CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_014371	Prevotella melaninogenica ATCC 25845 chromosome II, complete sequence	11 crisprs	DEDDh,cas3,PrimPol,csa3	1	1	3	2
NC_014370	Prevotella melaninogenica ATCC 25845 chromosome I, complete sequence	4 crisprs	WYL,DEDDh,PD-DExK	0	0	1	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_014371_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014371_1

206771-206876

Orphan

Consensus_repeat	Method
GGGGAGTGAACAGCGTGTTATCCCTAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014371_1

>merge|NC_014371|1|206771-206876|CRISPRCasFinder
GGGGAGTGAACAGCGTGTTATCCCTATGGTAGTCCTTTCGCCTTCCTCGAACCAGCAGTGAGCGTCGGTTTAGAACGGGGGGGAGTGAACAGCGTGTTATCCCTAT

>NC_014371|1|1|206771-206876|CRISPRCasFinder
GGGGAGTGAACAGCGTGTTATCCCTAT	GGTAGTCCTTTCGCCTTCCTCGAACCAGCAGTGAGCGTCGGTTTAGAACGGG
GGGGAGTGAACAGCGTGTTATCCCTAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_014371.1\|WP_013265520.1\|193859_195074_-\|glycoside-hydrolase-family-5-protein	unknown	unknown	gnl\|CDD\|365907
NC_014371.1\|WP_013265405.1\|202889_204839_-\|threonine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234752
NC_014371.1\|WP_044046172.1\|212853_214995_-\|M3-family-metallopeptidase	unknown	unknown	gnl\|CDD\|341051
NC_014371.1\|WP_013265502.1\|215701_216712_-\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376439
NC_014371.1\|WP_013265459.1\|197483_201500_-\|response-regulator	unknown	unknown	gnl\|CDD\|223715
NC_014371.1\|WP_044046171.1\|212063_212636_-\|murein-L,D-transpeptidase-catalytic-domain-family-protein	unknown	unknown	gnl\|CDD\|379310
NC_014371.1\|WP_009436018.1\|206018_206216_+\|50S-ribosomal-protein-L35	unknown	unknown	gnl\|CDD\|234676
NC_014371.1\|WP_013265814.1\|208230_208728_-\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_044046034.1\|195574_196792_+\|IS4-family-transposase	unknown	unknown	gnl\|CDD\|372999
NC_014371.1\|WP_009436028.1\|205224_205905_+\|translation-initiation-factor-IF-3	unknown	unknown	gnl\|CDD\|234582
NC_014371.1\|WP_167310039.1\|206976_207681_+\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_013265918.1\|188821_190597_-\|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein	unknown	unknown	gnl\|CDD\|378943
NC_014371.1\|WP_174254491.1\|208734_211320_-\|helix-hairpin-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|225094
NC_014371.1\|WP_044046035.1\|207731_208166_-\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_013265827.1\|187756_188755_-\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_013265148.1\|190655_193832_-\|SusC/RagA-family-TonB-linked-outer-membrane-protein	unknown	unknown	gnl\|CDD\|274948
NC_014371.1\|WP_044046036.1\|211509_212040_-\|50S-ribosomal-protein-L19	unknown	unknown	unknown
NC_014371.1\|WP_013265348.1\|217994_219461_+\|SLC13/DASS-family-transporter	unknown	unknown	gnl\|CDD\|238535
NC_014371.1\|WP_004383393.1\|206251_206596_+\|50S-ribosomal-protein-L20	unknown	unknown	gnl\|CDD\|179959
NC_014371.1\|WP_044046173.1\|216733_217864_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238561

Protein	Function_ID	Function_description	E-value
NC_014371.1\|WP_013265520.1\|193859_195074_-\|glycoside-hydrolase-family-5-protein	gnl\|CDD\|365907	pfam00150, Cellulase, Cellulase (glycosyl hydrolase family 5).	9.76418e-46
NC_014371.1\|WP_013265405.1\|202889_204839_-\|threonine--tRNA-ligase	gnl\|CDD\|234752	PRK00413, thrS, threonyl-tRNA synthetase; Reviewed.	0
NC_014371.1\|WP_044046172.1\|212853_214995_-\|M3-family-metallopeptidase	gnl\|CDD\|341051	cd06456, M3A_DCP, Peptidase family M3, dipeptidyl carboxypeptidase (DCP). Peptidase family M3 dipeptidyl carboxypeptidase (DCP; Dcp II; peptidyl dipeptidase; EC 3.4.15.5). This metal-binding M3A family also includes oligopeptidase A (OpdA; EC 3.4.24.70). DCP cleaves dipeptides off the C-termini of various peptides and proteins, the smallest substrate being N-blocked tripeptides and unblocked tetrapeptides. DCP from Escherichia coli is inhibited by the anti-hypertensive drug captopril, an inhibitor of the mammalian angiotensin converting enzyme (ACE, also called peptidyl dipeptidase A). OpdA may play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. It can also cleave N-acetyl-L-Ala. This family also includes Arabidopsis thaliana organellar oligopeptidase OOP (At5g65620), which plays a role in targeting peptide degradation in mitochondria and chloroplasts; it degrades peptide substrates that are between 8 to 23 amino acid residues, and shows a weak preference for hydrophobic residues (F/L) at the P1 position.	0
NC_014371.1\|WP_013265459.1\|197483_201500_-\|response-regulator	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	6.17671e-49
NC_014371.1\|WP_044046171.1\|212063_212636_-\|murein-L,D-transpeptidase-catalytic-domain-family-protein	gnl\|CDD\|379310	pfam13645, YkuD_2, L,D-transpeptidase catalytic domain. This family is related to pfam03734.	5.73918e-37
NC_014371.1\|WP_009436018.1\|206018_206216_+\|50S-ribosomal-protein-L35	gnl\|CDD\|234676	PRK00172, rpmI, 50S ribosomal protein L35; Reviewed.	1.7954e-20
NC_014371.1\|WP_013265502.1\|215701_216712_-\|iron-ABC-transporter-permease	gnl\|CDD\|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	1.1318e-67
NC_014371.1\|WP_174254491.1\|208734_211320_-\|helix-hairpin-helix-domain-containing-protein	gnl\|CDD\|225094	COG2183, Tex, Transcriptional accessory protein [Transcription].	5.63564e-120
NC_014371.1\|WP_009436028.1\|205224_205905_+\|translation-initiation-factor-IF-3	gnl\|CDD\|234582	PRK00028, infC, translation initiation factor IF-3; Reviewed.	3.51759e-83
NC_014371.1\|WP_044046034.1\|195574_196792_+\|IS4-family-transposase	gnl\|CDD\|372999	pfam14294, DUF4372, Domain of unknown function (DUF4372). This domain family is found in bacteria, and is approximately 80 amino acids in length. The family is found in association with pfam01609. There is a single completely conserved residue G that may be functionally important.	4.2794e-21
NC_014371.1\|WP_013265918.1\|188821_190597_-\|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein	gnl\|CDD\|378943	pfam12771, SusD-like_2, Starch-binding associating with outer membrane. SusD is a secreted starch-binding protein with an N-terminal lipid tail that allows it to associate with the outer membrane.	1.98634e-37
NC_014371.1\|WP_013265148.1\|190655_193832_-\|SusC/RagA-family-TonB-linked-outer-membrane-protein	gnl\|CDD\|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
NC_014371.1\|WP_013265348.1\|217994_219461_+\|SLC13/DASS-family-transporter	gnl\|CDD\|238535	cd01115, SLC13_permease, Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.	3.02559e-77
NC_014371.1\|WP_004383393.1\|206251_206596_+\|50S-ribosomal-protein-L20	gnl\|CDD\|179959	PRK05185, rplT, 50S ribosomal protein L20; Provisional.	9.70538e-60
NC_014371.1\|WP_044046173.1\|216733_217864_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|238561	cd01141, TroA_d, Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind their ligands in the cleft between these domains.	3.66834e-22

>NC_014371.1|WP_004383393.1|206251_206596_+|50S-ribosomal-protein-L20
MPRSVNHVASKAKRTRILKQTKGYYGARKNVWTVAKNTYEKGLTYAYRDRRNKKRNFRALWIQRINAAARLYDMSYSQLMGALHKAGIEINRKVLADLAVNNQEAFKAIVDKVK
>NC_014371.1|WP_009436018.1|206018_206216_+|50S-ribosomal-protein-L35
MPKQKTNSGAKKRFTFTGTGKIKRHHAYHSHILTKKTKKQKRNLVHQTLVDGTNLKQVRDLLRLR
>NC_014371.1|WP_009436028.1|205224_205905_+|translation-initiation-factor-IF-3
MKNDKMKMKYRVNEQIRVREVRVVSDDGAEVMPTRKALELAQKEGVDLVEISPNAQPPVCRIIDYSKFLYQQKKHQKEMKQKQVKQEVKEIRFGPQTDEHDYKFKLKHAQEFLNAGNKVRAYVFFRGRSILFKEQGEVLLLRFANDLEELAKVEQLPKLEGKKMFLYLAPKKAGVAKKSQQKRDREEAEAGAKAGAEGVSEEPKTDGGLFANAKNGADALKKLNID
>NC_014371.1|WP_013265405.1|202889_204839_-|threonine--tRNA-ligase
MVKITFPDGSVREYEQGVTGFQIAESISPALARDVVSCGVNGETTELNRPINEDATIALYKFDDEEGKHTFWHTSAHLLAEALQELYPGIQFGFGPAVENGFFYDVMPAEGQTISENDFPKIEEKMRELAKKNEQVVRRDVSKADAVKEFTADGQEYKVEHIVEDLEDGTISTYSQGNFTDLCRGPHLVSTGAIKAVKITSVAGAFWRGDAKREQMTRIYGITFPKKKMLDEYLEMLEEAKKRDHRKIGKEMELFMFSDRVGKGLPIWLPKGTQLRLRLQELLRRLLRPYNYQEVITPGIGGKNLYVTSGHYAHYGKDAFQPIHTPEEDEEYMLKPMNCPHHCEIYAHKPRSYKDLPLRIAEFGTVFRYEKSGELHGLTRVRTFTQDDAHIFVRPDQVKAEFENNIDIILKVFKTFGFDNYEAQISLRDPEDKEKYIGSDEVWEESEAAIKEACAEKGLNARVELGEAAFYGPKLDFMVKDAIGRRWQLGTIQVDYNLPNRFKLEYTAEDNSKKTPVMVHRAPFGSLERFTAVLIEHTAGHFPLWLTPDQVAILPISEKYNDYARKVKAYFDAHDVRSIMDDRNEKIGRKIRDNELKRVPYMVIVGEKEAAEGLVSMRQQGGGEQATMTMEAFAERINNEVAEQLKGLD
>NC_014371.1|WP_013265459.1|197483_201500_-|response-regulator
MLMLSNLNTDNGLSSARVYSIVEAEDGAMWISTKRGVDRYNGQQVRNYTLATDMQFSDASGRNIKLTKNSQQHIYAYDNKGKIYIYNKVKDTFQLQVNLMNVLGGSVVLNDLLVDDKGCFWMALDRGVYMMAPLSIAGSKDKTAYSSSNKGKYILKNTYVNHIRFFGKQLLIGSPSGVFAYSQNAAQPRLLLRGYSVLSSYHDVKAHQIWLGTFHRGILLLDDRTWKPLSSLTQFSSLSDIPLIPVRSIIPYDAATILMAVDGAGVYAYDKKTCKTNLLLNTDGRPENVLHGNGVYALCKDHLGDLWMGSYSGGVDMAIPMEHTLEFVRHENLNSQSLINNGVNDVMQSVDAQGRNSKIWYATDKGVSIYDEQTHLWHHSLYNKVALTLCQTADGKVLVGTYGDGIFQVHADGSSSRAYSVSNGKLKTDYVYSIFKDSEGGLWIGCLDGDLVHIPSSLEKNGNVDNSVNYLPINEVQSIVESPDKKIIAVGTTHGCYRIDKRSLRVSRFFYPSEFPSVDYNFFVNAMDFQDARHIWIATDGGGLYLYDWQKHQVKNYTISQSLPSNTVYALVKTPIGQVWMSTDKGLAFIDHGKVINLNFFKGLEREYKRMAVVRTQDGRMIFGSSEGAVVLASKFARGLNYKAPLHITGVEVEGKTFDEADQLEDWHAELFEMLQEGKMSFSHDEKTLIVHFESINYPYQHDIQYQYYLAGYDHQWSVPSAYQQARFANLPPGSYTLHVKAMGRSNGRILGESTLRIHIAQPWWNSWWAWIAYLCILGVIVYFGWDYYRERLHRKYYDDKINFFVNTAHNIRTPLSLVLAPLADLAKDTTLGDKSRKFLEMALCNGDKLLRMVTELLDFQKIAVVKTQVHMQKVELSVLLRQQVDKFQMSAQEKHLNLRLATCGQHTFSTDLSMMDLIFENLLSNAIKYTKVGGTITISASIDEIGKQVSIQVSDTGIGIPKIEAKHIFQSFFRASNAVNSQEMGSGLGLMLTRQLVQKLGGKLTFESEEGKGSTFLVVLPDNGYVDVSVSSKPSSLPETSDNSMSTDEKIKSEESLKDTLLFVDDNEDFRQYIRMAFADQYHVVDVESGEAALKYLSENGECDIVVSDVMMPGMQGDELCRSIKENKETSWLPVILLTAKAGRDFMIEGLDLGADDYIAKPFDSAILASKITSMLKNRCRLSQYYMERSLAIVRGEDSGQSSQKSLLPSEPSMSSASDEKNKSSDEKELGLDPMDQAFVEKATRLILDNLSDTDFTIDRLCREMAMSRTLFYGRLKTLTGQGPQDFIRLIRLEQAAQYLKQGDSVLDVSMKTGFVNVKYFSTVFKKHFGVSPSKYD
>NC_014371.1|WP_044046034.1|195574_196792_+|IS4-family-transposase
MGKSTHFIGQPVYNQVIKLLDKQQIKQISLETPRSEAYVKRLDGWTHLVIMLFVVLKHFDSLREVEIGMKAEVNKFHHLGIDYIVRRSTLADANKRRPQEFFASVYAYLLERYGSFLSDSRPKGEQKTWEKLLYMMDSTTITLFDNILKGVGRHPKSGKKKDGMKVHTVMKYHVGVPMVVQLTSAATHDHYLLKEVHLPKDATLTMDRAYVDYAQFQRLTEEGVCYVTKMKKNLTYTELSSVTYVSPDGLVTHTDKKIVFEKGEIRHQARRVELWSDNSHKSVVLLTNNLELDVKDLEEIYKRRWAIESLYKQLKQNFPLHFFYGDSVNAIQIQTWVVLIANLLCTVISRMIKRHVSFSQLVTMLRLTLMYYTDFISFMENPQNDELIIIAEKANSPPKELDLFD
>NC_014371.1|WP_013265520.1|193859_195074_-|glycoside-hydrolase-family-5-protein
MKRNLLKICLLFVSMFTVFSCSASPSVVDTPDTSESIPTAKQWNKDVVGWNLGNEFECSAPGQDGESMQIGNPDGSIHAETAWGNPVVTKKMIQAVKKAGFNAIRIPIRWQCHITNAQAMSIDKAWIARIKEVVGWCLDNDLKVIINAHHEKWLEGRPTYQYKDENCQKLALLWMNIASEFANYDSRLAFAGTNEVHVRDNWSKPTAENLEVQNAYNQIFVDMVRATGGNNAKRHLILQTYVCNPWFGIENGGFVIPKDAEGNGNNYMSVEFHYYQPWSYAGDCAYDYWGDAYKDVGKIPAENEKTMTDFFDKAMNTWSNKGLGIVIGEWGVTDHYKSNSVKVHENMTYYCKFLTTEARKRGFSTFVWDNNHFGNGSEKYGIFDRFKSMKVNAPWILEGIFGKE
>NC_014371.1|WP_013265148.1|190655_193832_-|SusC/RagA-family-TonB-linked-outer-membrane-protein
MRKKTMFLGMLGAGLMWMPTSAILAAQMNNAAMSVQQNQGIKGTVVDATGETLIGASVKVTGTTNGVVTDLDGNFTLNCKPGATLEVSYVGYKTMTVKAVNGMKIKMQVDSKALNEVVVTALGIKRDRKALGYGLEEVKGEELSKAKETNVINSLSGKVAGLVVQNTAGGASGSTRVLLRGNTEMAGNNQPLYVVDGVPLDNTNFGSAGESGGYDLGDGISAINPDDIETMTVLKGPAASALYGSRASHGVILITTKKAEKDKISVEYNGSYTVDTQLAKWDDIQEIYGAGYNGELPASSTSGTNTSWGPKADDFMFKYFDGEERPFLMHPNNASDFFRTGFTTQNSAILSVNSGKTGMRFSVTDMRNKDILPNTNMSRDNFNLRVNTSAGPVDFDFTANYTREKVKNRPALGDSQSNVGKNLMTLAGTYDQAWLKHYEDADGNYSNWNGNDQYNKNPYWDLYKNSNTSDKDVFRFTGKAIWNIDNHLKLQGTIGTDINSMNFEDFIAKTTPGTPAGKLTDQIFNNRTFNAEILALYNNSWGDFDVNATAGGNIFKVNNKTTTNVGLNQQMNGIQNIMNYQEQNTRESMYKKQISSLYASASLGYKHTYYLEGTLRGDRSSTLPTNNNTYVYPSVSGSLVFSEFIKNKKFINYGKIRASWAKVGSDTDPYLLALNYTTGKYSYSGYTIGMIANSTQPNKDLKPTMTDSYEVGLEMKFFNGRLGLDATYYNQNSKDQILSLASTTTSGYAYRLINAGEIQNQGIEIALNARALQIKDFAWDLGVNFSKNTNKVKSLTNGMDYFELAKAYWCGVSVGAKVGENYGAIRGHDFLYNDKGQVVVDAATGLPKVDQKIKTIGNSTWDWTGGFYSTFSYKNFRLSAAFDVKVGADIYSMSMRSAYQTGKAKGTLAGREEWYTSEEARKASGMDLAAWRETGNCKGFVVEGVIDNGDGTYRKNDIAVNPEDYWKHVANGVQSAFVYDNSYVKCREITFGYTFPESILGKYVKGLTVSFVARNPFIIWKNIPNIDPDSSYNTSGLGLEYGSLPSRKSYGLNVNVKF
>NC_014371.1|WP_013265918.1|188821_190597_-|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein
MNNIIKKYIGKSSLMMAFALMTTGTAMTSCSDETLSNINTDKTKVSELDPNAQLTTALLQTYGDFSLMDTYRNYISGFPQYFAGGWNVTNYAGSNFREDDIARRVWDRYYEVSIKNLVDAIHNSADKANLNAALRIHRVYLTAVLADTYGDVPCLEAGLGYISGISTPKYDTVEELYSWFFEELDACEKQLGTGTDRISGDVTSMGGDVAKWKKYANALRMRYAMRISDVNPQKAKEEFEKAVAAGAIASAADDAYIRYADTPYTYYDGANDYDFRTNALGEILYGQDATSPTMVCSTLFYQLQNTNDPRLYRICRHYYNIKRSQVKPDKEQNIDLTDDFLAYFRSKNLGEEPCNPGATWYTDWMSPATVDDLPTLKKYAEIDKNTYANSDYIARAGRPCLNIDFEMPSCPGDLMSYAEVEFLKAEAATKGWNVGGGDAESHYEAGVRASMELLNNYYLTSNKISKEEIDAFIANNPLGDNPKETINTQAWILHMMNPSEGWANMRRSDYPAILNRDLLTKNGFTYTDSNWSMPVRLQYPELEGQYNSANYKAAIDRMGGTDDWHKRLWWDKADVNLQPNFNPPFGKGYSK
>NC_014371.1|WP_013265827.1|187756_188755_-|hypothetical-protein
MNKTMKQYKGKVLKAMMMLFAMSFALAGTSTLSSCSSDDDPYFTVSENDDPRILNTDLADSKIDRKTNYKLEIKVTPVHYTTVTWLLDGTQIAEGTTIDQTLPLGNHELKIVATTTKGKTTSRTLNVTVTPAADDPALGTNAIELRVAPGETTTIHECKNLGLVQKVLIADKEVAFEVLDEGTTLKVTAPSDLANGDYDITLVDSNGVQFAGGTIKVTTEARQSVENTIWEGEFAVTWGTPFNALKDTFLSKVKAGTILRVYVNGNGQGTAATAWWNNILTGKGDPERGDIMVDGPAKWEFKLTDLSIQLLTEQDGFLLVGDGYTVKKVTIE
>NC_014371.1|WP_167310039.1|206976_207681_+|hypothetical-protein
MGVRLLFRYIVAILLLVVGVGQEAHAQYVITKETARCLTKQDSLLSDNFGQKVDGQLKGSYRADTVSLIDKYFRRGMSRKGILMIPKGKRPAPETYLKRRYIRRHLKNFKAGASCIVSKELLERYHGDSIGKADNSQFIMMKSEMDSVLMRSHGDLSRIEHELGIPAGAWKHRVLVRIDIPKPKKLKLRMPSGNEIGANVLWLPGGLLPTGYKEAVIDRIPKGKYKASLIEITQ
>NC_014371.1|WP_044046035.1|207731_208166_-|hypothetical-protein
MHDIIGGFIGLTLVHIGAALRFVYHRFIIRDNYSYHSLITESPVFDCFKESYKEQFKRWKQRQIQRNQAYDIDLNEEQQQTLEMFLKEGRSKKEIIQGMIETGELKLIDVDIYPRNPEYFSNRVLDGIIGLCFLIILILIIHYI
>NC_014371.1|WP_013265814.1|208230_208728_-|hypothetical-protein
MNQTKKILAYLGCIAFTALGVWLLTIENPTTTYPLWTIRVTGILSIIFFGGGGLFMAYKKVKLLINHKKEIEFTDRGISICGAEEILWNEIADFSLIRFKGNRLITIQMKNPEKVIANEPSWIKRKTMEYNLKTINALYSFPAYMMDGRAEEALTLCKLNLAKHK
>NC_014371.1|WP_174254491.1|208734_211320_-|helix-hairpin-helix-domain-containing-protein
MSHSLSLPLQSVSAVLTLLNEGCTIPFISRYRKERTGGLDEVQITDISELYDRLKELGKRKETILRTIREQEKLTPELEAKILACMDSTELEDIYLPYKPKRRTRAQIAREQGLEPLALAIMREAQKPTAPPDLPEGGGDKLASILQKYQGRAKESLSSRVRIGTPPLSGRSGGALALDIIAEIVSENQQARNTVRTAYQRGAVITSKVIKKMKDTDEAQKFADYFDFSEPLRRCNSHRLLAMRRGEDQGILRVSITIDGEECIARLTRQFVRGHGVCQTLVSQAVEDSFKRLINPSIENEFAALSKGRADEEAIKVFTENLRQLLLSPPLGQKRVLALDPGFANGCKIACLDEQGNLLHHEIIYPHPPRNQVRQATEALQRMINTYNIEAIAIGNGTASRESKEFVENITTETTTGPSPSPLPHREGSDYRHLPKSKQQFTDNTSPINSKPQSAGHTTPLPLGEGSGEGPVRPVGPVGSASSLFIFLVSEDGASIYSASPVAREEFPDEDVTTRGAISIGRRLMDPLAELVKIDPKSIGVGQYQHDVDQSKLKHSLDQTVMSCVNQVGVNLNTASLHLLTYVSGLGPALARNIIDYRREHGPFTSRAQLKKVKRLGDTAYQQCAGFLRIPDAKNPLDNSAVHPESYHIVEQMAKDLKCTIKDLIGNKKLLAEIDVKRYLTPQPPLRRERGSEASPNPSERRGGAPPNLPEKGGVPMRTREDKGALNLPQHLSNVSTSLPPLLSEGSGEATLRDILTELEKPGRDPRGEVEVFEFDKNVHTLSDLIIGMELPGIVTNITNFGAFVDIGVHQDGLVHISQLSDRFVTDPTQVIRLHQHVRVRVVEVDMRRKRIALSMKNIKQ
>NC_014371.1|WP_044046036.1|211509_212040_-|50S-ribosomal-protein-L19
MELNLKRTLTCIILTVLTTLSTHAQTLCVIDGTPLPDSLLHVTIDEMRSDSAKEIVAKRLGLIPPQAIESIQTFAVEEQIRQGKNIIFCKPPKDIIIMRTNSLAELQWVINGKLRKPRKKLTIIDYKLSPQRITEALPKGIKPTDIGSVNILTYINDPRQEKHPTIVIKTKSLTTK
>NC_014371.1|WP_044046171.1|212063_212636_-|murein-L,D-transpeptidase-catalytic-domain-family-protein
MLLSLLTLNFGVKGYWKIKSYSFQSYFKDVWEICHEKGYNEDYCILVDFSRPSGEDRMAIIDLKTLSVLDTGPCAHGKGKGNSAWKPVFSNKEGSRCSSLGAFKIAEKGYSATVGLRFALDGLDASNSNARRRNILIHSSRYVGIMHHLTSYLPLSDASWGCFTTSPAMLKKIEALCDKSKKPILLYAYK
>NC_014371.1|WP_044046172.1|212853_214995_-|M3-family-metallopeptidase
MKQNLKNVVLAAGLACTALTGQAQKARPKTTQTVSNSLMKQSTLPFNAPDFSRIKGEDYLPAIKAAIAEQRAEIKKITDNKQKPTFANTILAYERSGKDLERISNIFYALVSADKTPEIEKAQGSIVPLMTEFENEIKFNQKFFQRIKYVYDHEYKTLKGEDKKLLEVVYKDFTHAGALLPKEKMARMQEINKELAKLQQEFGDMLPKAANEATVWVSDVKELAGLSETDIAQCKKDAESRGGKAPYCIVITNTTQQPILASLENRGLRERVYNASIHRTDGTGAYNTFPVIVKIARLRAEKAQLMGYKNYASYSLSKTMAKNTDNVYAFLHQMIEAYKPKSEAQTKAIEEYAQKTEGADFRLQPYDRFYYSAKMKKDQYSFSDDDVKPYFNLDSVLVNGIFYAAHRVYGLSFRERKDIPTYHKDMKVFDVIDANGKQLALFYCDYFRRPTKRGGAWMSAFLKQSGDRHQKPLIYNVCNYAKAPEGQPTLLTWDETQTMFHEFGHALHGMLSNCKYNTLSGTAVSRDFVEMPSQFNESFASIPEVFNNYARHYKTNEPMPDALREKMLGSLNFLSAYALGENLSATSVDLAWHCLSPSEVPTVEEAPAFEKKVLADMGLLNNQIPPRYSTSYFNHIWGGGYAAGYYSYLWSEVLAANIADYFEAHGALTRKVGDDFRQKILSRGNTRDLMQIFSDFTGLKAPDTKGLLKARGM
>NC_014371.1|WP_013265502.1|215701_216712_-|iron-ABC-transporter-permease
MKRNILLFICLATSILLLFGLNLTTGSVQIPFADILDILCGRFIGKESWEYIILENRLPQTLTAILCGASLSVCGLMLQTAFRNPLAGPDVFGISSGAGLGVALVMLLLGGTVSTSIFTVSGFLAILTAAFVGAIAVTVLILFLSTLVRNSVLLLIVGIMVGYVSSSAVSLLNFFASEEGVKSYMVWGMGNFGAVSMNHIPPFSILCLIGIIASFLLVKPLNILLLGPQYAESLGISTRQIRNILLVVVGLLTAITTAFCGPISFIGLAIPHIARLLFRTENHQILLPGTVLSGAVIALLCNFICYLPGESGIIPLNAVTPLIGAPVIIYVIIQRR
>NC_014371.1|WP_044046173.1|216733_217864_-|ABC-transporter-substrate-binding-protein
MRQLLVFTLSVLLFLSCGNHQKQVADKSEKEEKGDKTELQYARNITIERTKDYVVVRLLNPWKAGTVLHTYYLVERGKDVNVPDDGTKVVIPLRKSVIFTTAHANLVEMLHAQKAIAGVADLKYMIIPDIQKRARKRGGIVDCGDAMKPDVERIIDLNADAILLSPFENNGGYGRLEQIGVPIIECADYMERSALGRAEWMKFYGILFGREHEADSLFAVVKQNYKSLSQKASQSKVTRSVLPDRKVGAVWYLPGGESSVGLLYKDAHGRYAYSNDKHSGSLAMPFETILDKFAQSDFWILSYNSNFNRRVLLAEYQGYAKLKPYQTKEIYGCKIDSKPYFEEVSWRPDWLLSDLIQLFHPDLKIAPLRYYQKLED
>NC_014371.1|WP_013265348.1|217994_219461_+|SLC13/DASS-family-transporter
MAEEKTNELGNHIEMKKVWELLAILVVTAIIWNLPTSSFGIDGLTVVQQRIIAIFVFATLSWLTECIPAWATSLSIMSIMCVTVSKNAFGVFKGDGIGELLDSKEIMASFADPIIMLFLAGFILAIAASKSGLDTLLARNLIKPFGNKSENVLLGFLLITGLFSMFISNTATAALMLTFLTPVFAALPANGKGRIALTMSIPIAANLGGMGTPIGTPPNLIALKYLNDPAGLNMNIDFMHWMAFMAPLVIVLLLLSWRIILYFFPFTQKTIHLKIDGEVHRGWRMWVVIITFIVTILLWVIPKDVTGIDTNTVSMIPMAIFAITGVITAKDMQEINWSVIWMVAGGFAIGLGMNGSGLADAAIESIPFGNWSPIVILAISGLICYFLSNFISNTATAALLVPILAVVCRGMGDKLGGIGGTSTVLIGIAIAASTAMCLPISTPPNAIAYSTGLVKQNDMLKVGLTSGVVSLILGYILLYFIGQIHFLG

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Crispr_ID: NC_014371_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014371_2

781237-781340

Orphan

Consensus_repeat	Method
TTGTATAGTTGGCAAGTGAACGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014371_2

>merge|NC_014371|2|781237-781340|CRISPRCasFinder
TTGTCAAGTAAACAAGTTGACGAGTAAACAAGTTGCTTGTATAGTTGGCAAGTGAACGAGTTGACGAGTAAACAAGTTGCTTGTGTAGTTGACAAGTGAACAGG

>NC_014371|2|2|781237-781340|CRISPRCasFinder
TTGTCAAGTAAACAAGTTGACGAG	TAAACAAGTTGCTTGTATAGTTGGCAAGTGAACGAGTTGACGAGTAAACAAGTTGC
TTGTGTAGTTGACAAGTGAACAGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_014371.1\|WP_013265545.1\|772633_774253_+\|BACON-domain-containing-protein	unknown	unknown	gnl\|CDD\|271342
NC_014371.1\|WP_013265449.1\|784074_785298_+\|restriction-endonuclease-subunit-S	unknown	unknown	gnl\|CDD\|341202
NC_014371.1\|WP_013265322.1\|790085_791204_-\|endoglycosidase	unknown	unknown	gnl\|CDD\|119359
NC_014371.1\|WP_013265730.1\|767305_768916_-\|CTP-synthase	unknown	unknown	gnl\|CDD\|235437
NC_014371.1\|WP_013265602.1\|785313_788514_+\|type-I-restriction-endonuclease-subunit-R	unknown	unknown	gnl\|CDD\|223683
NC_014371.1\|WP_013265123.1\|782384_784061_+\|type-I-restriction-modification-system-subunit-M	unknown	unknown	gnl\|CDD\|280533
NC_014371.1\|WP_013265381.1\|791221_792847_-\|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein	unknown	unknown	gnl\|CDD\|372283
NC_014371.1\|WP_013265397.1\|797551_797929_-\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_044046194.1\|769712_769958_+\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_013265519.1\|774289_775891_+\|BACON-domain-containing-protein	unknown	unknown	gnl\|CDD\|271342
NC_014371.1\|WP_013265714.1\|770886_771699_+\|PepSY-domain-containing-protein	unknown	unknown	gnl\|CDD\|377164
NC_014371.1\|WP_044046079.1\|799955_800471_+\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_013265837.1\|775906_778663_+\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173811
NC_014371.1\|WP_044046077.1\|778674_779628_+\|PorV/PorQ-family-protein	unknown	unknown	unknown
NC_014371.1\|WP_013265872.1\|792853_795964_-\|SusC/RagA-family-TonB-linked-outer-membrane-protein	unknown	unknown	gnl\|CDD\|274948
NC_014371.1\|WP_013265155.1\|765373_767305_-\|membrane-protein-insertase-YidC	unknown	unknown	gnl\|CDD\|234942
NC_014371.1\|WP_013265441.1\|769954_770680_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|187608
NC_014371.1\|WP_013265601.1\|788899_790045_-\|DUF1735-domain-containing-protein	unknown	unknown	gnl\|CDD\|378016
NC_014371.1\|WP_004359657.1\|796317_797421_-\|Mrp/NBP35-family-ATP-binding-protein	unknown	unknown	gnl\|CDD\|378455
NC_014371.1\|WP_044046076.1\|763211_765371_-\|S9-family-peptidase	unknown	unknown	gnl\|CDD\|224423

Protein	Function_ID	Function_description	E-value
NC_014371.1\|WP_013265545.1\|772633_774253_+\|BACON-domain-containing-protein	gnl\|CDD\|271342	cd14948, BACON, Bacteroidetes-Associated Carbohydrate-binding (putative) Often N-terminal (BACON) domain. The BACON domain is found in diverse domain architectures and accociated with a wide variety of domains, including carbohydrate-active enzymes and proteases. It was named for its suggested function of carbohydrate binding; the latter was inferred from domain architectures, sequence conservation, and phyletic distribution. However, recent experimental data suggest that its primary function in Bacteroides ovatus endo-xyloglucanase BoGH5A is to distance the catalytic module from the cell surface and confer additional mobility to the catalytic domain for attack of the polysaccharide. No evidence for a direct role in carbohydrate binding could be found in that case. The large majority of BACON domains are found in Bacteroidetes.	6.54743e-12
NC_014371.1\|WP_013265449.1\|784074_785298_+\|restriction-endonuclease-subunit-S	gnl\|CDD\|341202	cd17521, RMtype1_S_Sau13435ORF2165P_TRD2-CR2_like, Type I restriction-modification system specificity (S) subunit TRD-CR, similar to Staphylococcus aureus NCTC 13435 S subunit (S.Sau13435ORF2165P) TRD2-CR2, Escherichia coli E24377A S subunit (S.EcoE24377ORF286P) TRD1-CR1 and Pseudoalteromonas species P1-13-1a S. subunit (S.Psp1bORF2093P) TRD2-CR2. Staphylococcus aureus NCTC 13435 S subunit (S.Sau13435ORF2165P) recognizes 5'... TCTANNNNNNRTTC ... 3', and the recognition sequences of Escherichia coli E24377A S subunit (S.EcoE24377ORF286P) and Pseudoalteromonas species P1-13-1a S subunit (S.Psp1bORF2093P) are undetermined. The restriction-modification (RM) system S subunit generally consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. For example, Staphylococcus aureus NCTC 13435 S subunit (S.Sau13435ORF2165P) TRD1 recognizes TCTA/TAGA, and -TRD2 recognizes GAAY/RTTC. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one heteromeric enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. In addition, this family includes RMtype1_S_TRD-CR_like domains of various putative Helicobacter type II restriction enzymes and methyltransferases, such as Hci611ORFHP and HfeORF12890P.	1.95866e-71
NC_014371.1\|WP_013265322.1\|790085_791204_-\|endoglycosidase	gnl\|CDD\|119359	cd06542, GH18_EndoS-like, Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain. Some members also have an additional C-terminal glycosyl hydrolase family 20 (GH20) domain while others have an N-terminal domain of unknown function (pfam08522). Members of this family include endo-beta-N-acetylglucosaminidase S (EndoS) from Streptococcus pyogenes, EndoF1, EndoF2, EndoF3, and EndoH from Flavobacterium meningosepticum, and EndoE from Enterococcus faecalis. EndoS is a secreted endoglycosidase from Streptococcus pyogenes that specifically hydrolyzes the glycan on human IgG between two core N-acetylglucosamine residues. EndoE is a secreted endoglycosidase, encoded by the ndoE gene in Enterococcus faecalis, that hydrolyzes the glycan on human RNase B.	3.54753e-38
NC_014371.1\|WP_013265730.1\|767305_768916_-\|CTP-synthase	gnl\|CDD\|235437	PRK05380, pyrG, CTP synthetase; Validated.	0
NC_014371.1\|WP_013265602.1\|785313_788514_+\|type-I-restriction-endonuclease-subunit-R	gnl\|CDD\|223683	COG0610, COG0610, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms].	4.22971e-142
NC_014371.1\|WP_013265123.1\|782384_784061_+\|type-I-restriction-modification-system-subunit-M	gnl\|CDD\|280533	pfam02384, N6_Mtase, N-6 DNA Methylase. Restriction-modification (R-M) systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The R-M system is a complex containing three polypeptides: M (this family), S (pfam01420), and R. This family consists of N-6 adenine-specific DNA methylase EC:2.1.1.72 from Type I and Type IC restriction systems. These methylases have the same sequence specificity as their corresponding restriction enzymes.	1.95381e-85
NC_014371.1\|WP_013265381.1\|791221_792847_-\|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein	gnl\|CDD\|372283	pfam12741, SusD-like, Susd and RagB outer membrane lipoprotein. This is a family of SusD-like proteins, one member of which, BT1043, is an outer membrane lipoprotein involved in host glycan metabolism. The structures of this and SusD-homologs in the family are dominated by tetratrico peptide repeats that may facilitate association with outer membrane beta-barrel transporters required for glycan uptake. The structure of BT1043 complexed with N-acetyllactosamine reveals that recognition is mediated via hydrogen bonding interactions with the reducing end of beta-N-acetylglucosamine, suggesting a role in binding glycans liberated from the mucin polypeptide. Mammalian distal gut bacteria have an expanded capacity to utilize glycans. In the absence of dietary sources, some species rely on host-derived mucosal glycans. The ability of Bacteroides thetaiotaomicron, a prominent human gut symbiont, to forage host glycans contributes to both its ability to persist within an individual host and its ability to be transmitted naturally to new hosts at birth.	0
NC_014371.1\|WP_013265519.1\|774289_775891_+\|BACON-domain-containing-protein	gnl\|CDD\|271342	cd14948, BACON, Bacteroidetes-Associated Carbohydrate-binding (putative) Often N-terminal (BACON) domain. The BACON domain is found in diverse domain architectures and accociated with a wide variety of domains, including carbohydrate-active enzymes and proteases. It was named for its suggested function of carbohydrate binding; the latter was inferred from domain architectures, sequence conservation, and phyletic distribution. However, recent experimental data suggest that its primary function in Bacteroides ovatus endo-xyloglucanase BoGH5A is to distance the catalytic module from the cell surface and confer additional mobility to the catalytic domain for attack of the polysaccharide. No evidence for a direct role in carbohydrate binding could be found in that case. The large majority of BACON domains are found in Bacteroidetes.	3.84982e-16
NC_014371.1\|WP_013265714.1\|770886_771699_+\|PepSY-domain-containing-protein	gnl\|CDD\|377164	pfam03929, PepSY_TM, PepSY-associated TM region. The PepSY_TM family is so named because it is an alignment of up to five transmembranes helices found in bacterial species some of which carry a nested PepSY domain, pfam03413.	1.27613e-34
NC_014371.1\|WP_013265837.1\|775906_778663_+\|S8-family-serine-peptidase	gnl\|CDD\|173811	cd07485, Peptidases_S8_Fervidolysin_like, Peptidase S8 family domain in Fervidolysin. Fervidolysin found in Fervidobacterium pennivorans is an extracellular subtilisin-like keratinase. It is contains a signal peptide, a propeptide, and a catalytic region. The tertiary structure of fervidolysin is similar to that of subtilisin. It contains a Asp/His/Ser catalytic triad and is a member of the peptidase S8 (subtilisin and kexin) family. The catalytic triad is similar to that found in trypsin-like proteases, but it does not share their three-dimensional structure and are not homologous to trypsin. Serine acts as a nucleophile, aspartate as an electrophile, and histidine as a base. The S53 family contains a catalytic triad Glu/Asp/Ser with an additional acidic residue Asp in the oxyanion hole, similar to that of subtilisin. The serine residue here is the nucleophilic equivalent of the serine residue in the S8 family, while glutamic acid has the same role here as the histidine base. However, the aspartic acid residue that acts as an electrophile is quite different. In S53, it follows glutamic acid, while in S8 it precedes histidine. The stability of these enzymes may be enhanced by calcium; some members have been shown to bind up to 4 ions via binding sites with different affinity. There is a great diversity in the characteristics of their members: some contain disulfide bonds, some are intracellular while others are extracellular, some function at extreme temperatures, and others at high or low pH values.	1.25562e-83
NC_014371.1\|WP_013265872.1\|792853_795964_-\|SusC/RagA-family-TonB-linked-outer-membrane-protein	gnl\|CDD\|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
NC_014371.1\|WP_013265155.1\|765373_767305_-\|membrane-protein-insertase-YidC	gnl\|CDD\|234942	PRK01318, PRK01318, membrane protein insertase; Provisional.	1.09405e-100
NC_014371.1\|WP_013265441.1\|769954_770680_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|187608	cd05350, SDR_c6, classical (c) SDR, subgroup 6. These proteins are members of the classical SDR family, with a canonical active site tetrad and a fairly well conserved typical Gly-rich NAD-binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	3.73694e-47
NC_014371.1\|WP_013265601.1\|788899_790045_-\|DUF1735-domain-containing-protein	gnl\|CDD\|378016	pfam08522, DUF1735, Domain of unknown function (DUF1735). This domain of unknown function is found in a number of bacterial proteins including acylhydrolases. The structure of this domain has a beta-sandwich fold.	2.2566e-16
NC_014371.1\|WP_004359657.1\|796317_797421_-\|Mrp/NBP35-family-ATP-binding-protein	gnl\|CDD\|378455	pfam10609, ParA, NUBPL iron-transfer P-loop NTPase. This family contains ATPases involved in plasmid partitioning. It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits.	1.83825e-134
NC_014371.1\|WP_044046076.1\|763211_765371_-\|S9-family-peptidase	gnl\|CDD\|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	3.56837e-78

>NC_014371.1|WP_044046077.1|778674_779628_+|PorV/PorQ-family-protein
MNTKHIILMACAALLGATQANAQGQDLSILTANTDARTAAMGNASAAAEGMYLYNNPAAFFATDKKFTADASASLFEKAEGADGTFGIYALSAGYKLAKRHAVFVGFRYAGGLSLKGSDLLGNPTKDYKPYNWTLDLGYTYFLGKGFATYATGSLIYSHLSKNATGAVFSVGGAYQNNELTLANKPANLMLDAKVGAIGPQLDYGNKHKTTLPTYLAVGGALSVEVAEKHQVAAALSSRYFFQPSEAKLFMLGGGLEYTYNKMVSVRAGYEYGDHDLSHVTMGAGFKYHGLRLNGAYNLKTADTGSSYCTIGIGYDF
>NC_014371.1|WP_013265837.1|775906_778663_+|S8-family-serine-peptidase
MRKSIIYLCACALSGMMVTTSCQDNLDSDAGVSNTRSVNIDKDLFAIKGCINVKLAKGTNQAIPTTRSGSVEMQSVPSAMTSAMQYSGAYKMERVFKPAGIYEARTVAEGLDRWYTIYFDKSKDVAAVLDQFKKAEGVECAEQVLPMARPTVKMTPYSPSGASMQATASTFDDPLLAKQWHYYNDGSVNARAKKGADCNVKPVWEKYTTGKKNVIVAVVDGGIDITHEDLKDNLYVNEKEKNGQPNVDDDGNGFVDDIYGYNFVTAKDVVGGTIEPDDGGHGTHVAGTVAARNNNGKGVAGIAGGDGSPDSGVRLLSCQIFRNKDEQGDAAAAIKYAADNGAVICQNSWGYSSTAGVTSMPQLLKEAVDYFIKMAGCDANGNQRPDSPMKGGVVMFAAGNENKEFSAYPACYAPTVSVAAMAWDFSKASYSNYAKWVTITAPGGDQDRFGTEAGVLSTVPKKKVASGYAYFQGTSMACPHVSGIAALIASYFGRQGFTNEELKSRLITAYRPYNIDEQNPTYKGKLGKGYIDAEAAFETDTKIAPEKVGTLTLKPDFVDINAEWSIAKDEDKTAAFYRLYIAQGELTADKLKDMTYREINGMGHSLGETLKYDFDDLKDNTTYSVAVVAVDRWGNLSEPMIQKCTTRLNHAPEATNFPTEAIEVMENDRKSFSFNVADPDGHNWDIKATGETKGVSYTVKGNTVTVNLVPVLEAGSYNCTFILSDDLGAKAEKSFTFKIVKYIPPQLTKPFENYIIGLDEGVVTIPLTGHYTHSGNTQLTYKATAANGSIATATISNDNLQLKGMAKGVTRISIAATDGRETSSDGSFQVRVVEKKSAPVYAVYPIPVQRDIHTLLNPEVKQAELVISSTVGERLMKATVTPDKNNVATLDLSKLNPGTYKLTVYTSKGNHTQMFIKR
>NC_014371.1|WP_013265519.1|774289_775891_+|BACON-domain-containing-protein
MRIINIHKLLQFSLLYLLLGIAVGCAENDSFDQPYLNVSEKEISFSNQIGEKTITVNTNCKEWMATTPKAWVHLSQSGNEIAVHVDPNTTGMERSSYILVDGGLAVQKIMVSQSAADITLNLNNGEVILPQAGGTTTVDLKMDATSYDLTQSEQPEWMQVIKKKHGLKFISKPNYSTTERTTKLTIAFAGKNHEVVVKQPGVATFILACNPGNPYSLHKMMDYEYRRGSFLTEYGGPDEVNGIFEESYFFKTPSPLFKDVVYVHDTKHSVPTRIYTRSLTREGVNAVKSQAFQEFMRANGYTRDEKDTNHYVNIKEAFTMDVDIREENNSVVLFFYQMHTQDRSYPTFSSLDLGPVDLLNKTDKKISDVEAYETGKNSEEMKRQMSKSNEVEAILYKTNDPTLIARTYFFYLHNDAAVPQEKAGSVEQYSLFYSQPNLGIWQYGNEWFVTHEFDKLLTANNFEFVGYNGKHHVYARRSDYLTLAISGGEYADVNNGKAVMQITVLYKPTVFAGSKEQRLAKVERMLKQYNPKK
>NC_014371.1|WP_013265545.1|772633_774253_+|BACON-domain-containing-protein
MELKKTLYSLMLGGILLCLFSCAKEDEFEMPTLVLSENSIAFDKGVSERNISVTTNQNSWIASSPQEGDWLSLVQDGNVLKVKVTENKIGTERTSYVLVNANGASGKIAVTQSAADVTLDVVPNAIYLPQTGGEKTIDITTNSSVYDVTTSEEVSWLKIVKSEEEIKLIAERNDTYQKREVKLYAKSGSVIREIVVSQSGIQRYLLPIHPGVPQDEHKIMDFELGRGSYLREYQAAMPAYGLEETYTFITASPIFTLIQYCSTDGINPSQIIMIGDGRKAIDAVKDKAFDKFLTDNGYVRSNSQSDREYTNDKDLLSLKVYISEKENNEGVNLTFTPIMKQNGEYKTFSKLPFYPLELLQKDNVKLAQIEQYEQKAGSTEEERSLNEHKNTEVSQIQYKLKASTDPSAAYGRIHIFYTTDKDGDAPDNLGSVQIGALLFKDTNLGVWKYGTKWVATKEIKKVLGDEGFSFLRTSGNNHFFVRESDHLVIDVTCVLDNAMPVLALLYSYDPSVSGASSKAIKTQAKMIRNFAAAKKALKF
>NC_014371.1|WP_013265714.1|770886_771699_+|PepSY-domain-containing-protein
MRKFCLKIHRWFALPLGVIMAILCFSGLAILLIKDLAPLFDMNAKEMPIYTIVVRLHRWLFMKPENAHEGGQSLGRILTAVSAICMSIVLLSGVVIWWPKTKKALKSRLTVSTNKGFRRFVYDSHVSLGIYVFIFLFLMALTGPVFSFGWYRAGMSKLFGQPMPPKEMKMQQPKDGMKQGGTNDKAFAPTDASQMKGQPQAHKEGAKDMKGDQHGKKPKGGKLFKQLHTGTWGGWFSRVLYAIAALIGGFLPISGYYLWWKRRSAKKKKA
>NC_014371.1|WP_013265441.1|769954_770680_+|SDR-family-NAD(P)-dependent-oxidoreductase
MKKAIVVGASSGIGHEVARLLIAEGWAVGVAARRIDKLTDLQAMAPERVYTVQIDVTNEDAETSLLQLIERMNGIDLYFHAAGIGWQNPSLNADIELKTMETNAVGFTRMIGCAYRYFANKGGGHIACITSIAGTKGLGPAPAYSATKAMQNTYLQALEQLAACKHHNIHFTDIRPGFVDTPLLAGTSHLPMLMTTKKVARSIIKAINSRRHICVIDSRWCVLTYLWRHIPNWIWRRMKLC
>NC_014371.1|WP_044046194.1|769712_769958_+|hypothetical-protein
MELDTTNMCSHLQKKLFNEEGVYYPIWQAMQNDDEITAVIRSRQLHIYRNGKKVLVLPGKAAPKIIREDSLNELLPKDLLK
>NC_014371.1|WP_013265730.1|767305_768916_-|CTP-synthase
MAETKYIFVTGGVVSSLGKGIISSSIGKLLQARGYNITIQKFDPYINIDPGTLNPYEHGECYVTEDGMETDLDLGHYERFTGIKTTKANSMTTGRIYKSVIDKERRGDYLGKTIQVVPHITDEIKRNIKLLGQKYHYDFVITEIGGTIGDIESAPFLEAIRQLKWELGKRAINLHLTYVPYLKAAGELKTKPTQHSVKELQSVGIQPDVLVMRTEKHLDDDIRKKVAAFCNVDFDCVVQSEDLPSIYDVPVNMLEQGLDAAILRKCGEEVGPKPALGPWKEFLDRQRKATKEVHIGLVGKYDLQDAYKSIREGLLQAGTYNDRKTVITFINSEELTEENVAEKLKGQDGIVICPGFGQRGIEGKIVAAHYTRTHDIPTFGICLGMQMMVIEFARNVLGYKDANSREIDEKTTHNVIDIMEEQKNITNMGGTMRLGAYECVLRQGSHTFNIYKQEHIQERHRHRYEFNNDYEKEFEKHGMMCVGRNPESDLVEIVEIPGLKWYIGTQFHPEYQSTVLGPHPLFLDFVKTSIENQKNK
>NC_014371.1|WP_013265155.1|765373_767305_-|membrane-protein-insertase-YidC
MDKRTITGFVLIALILFGFAWWQQPSAEQVAQQRAEFVKDSIASAKKAQTAKLAAEKQAQQKAAQATDTTALFYAALNGKAQDIILKNSKVELTLSTKGGVVKKAVIKNYIGHNIAVKDGSQDQKNVTLFSGDDQSLNFMLAAKNSNIETKDLIFTPSNVTDSTVTLTAVAGEGKTLTLNYTLGKDYLLNMSLQAEGMGGLFAPNYNQIDINWQERCKQQERGFTFENRYATLTYKKHDGGTDYLSETSEKEETTEDSMDWVAFKNQFFSAVMIAKDNFATGAKLKSTPLEKSSHYLKHYEANMKAGFDPTGKRPSEFEFYFGPNDFRLLQSVETESKFAKELDMERLVYLGWPLFRIINRWFTLYVFDWLSKVFPMGVVLILITLLLKLITFPMVKKSYMSSAKMRVLKPKLDEATKQFNKPEDQMQKQQAMMQKYSEYGVSPLSGCLPMLIQMPIWIAMFNFVPNAIQLRGQSFLWMHDLSTFDPIFSWSHDVWLVGDHISLTCILFCGANLLYTWFTMQQQKDQMVGQQADQMKMMQWMMFGMPLFFFFMFNDYSSGLNFYYFISLFFSAAIMWALRKTTNEEKLLAILEARREERKNNPKNNMGSGLFARMQALQELQKQQQEELRRKQDELNKKKKGL
>NC_014371.1|WP_044046076.1|763211_765371_-|S9-family-peptidase
MNKNLTMAMTAALMMSGSVAQAQDVNIGRSNITLTSDLMTPETLWAMGRIGAAQASPDGKKIVYQVGYYSVKENKGHQVLRVMDADGKNDRLLTTSAKSEGDAAWVDNNTLAFLTGGQLWTMNADGTNRKQLTHSDIDIEGFRFSPDRKRVVLIKSIPYYGTIKQNPSDLPKATGMVITDMNYRHWDHYVTTNAHPFVADVTPEGIGAGIDVLEGEPYESPLAPFGGIEQIDWSKDSKFIAYTCRKKEGTQYAISTDADIYIYNVETRQTKNLCKPADYVEPKIDATKSMRNQAVNHQAGDMNVGYDVNPKFSPDGKYIAWQSMKNDGYESDRNRLCVYELATGKKTYVAESFDSNVDDYTWSLNSKDLYFIGVWHATVNVYQTNLKGEVKQLTEGDHNYVSISLLGDKKLLAIRQSISQANEIFAITPAKKEKASVQTQLSFENKHIYDQLALGDVKSRWVKTTDGKEMMEWVITPPHFDPNKKYPTLLFCEGGPQSPVSQFWSYRWNFQIMAANGYVIIAPNRRGLPGFGSAWNEEVSTDWTGQCMNDYLSAIDDAANNLSFVDKDRLGAVGASFGGFSVYYLAGIHNKRFKCFISHDGAFNLESMYTDTEEAWFSNWEYDDAYWNKDKSEAAKRTYANSPHLNVDKWDTPILCIHGEKDYRINANQGMGAFNAARLRGIPAELLLYPDENHWVLKPQNSVLWQRTFFNWLDRWLKK
>NC_014371.1|WP_013265123.1|782384_784061_+|type-I-restriction-modification-system-subunit-M
MTSTELKDLEGRLWQSADMLRAGAHLAANKYSQPILGLIFLRYADVLFKQHKEAIDTAYNEYKGTRMERSYKDIAIEKCGFFLPECAYFDYLNDAPDDAQKALLVKAAMEAIEHENPRMDGVLPKEVYGQLVPEEEPELLSRIVRVFKDIPENISIDIFGQIYEYFLGNFALAEGQGGGAFYTPASVVQYMVEVLQPATGDKKFLDPACGSGGMFVQAARYMHRHNTSNEQMMNFRCYGVEKEPDTVKLAKMNLLLNNVRGEIMEANSFYSDPYNAVGQFDYVMANPPFNVDEVVVERVTDDARFNTYGVPRNKTKSAKKASDKKETVPNANYLWIGYFATALNEQGKAALVMANSASDAGGSELEIRKKMIEDGIISQMVTLPSNMFSTVTLPATLWFFNKKRPKKDEILFIDARNIFTQVDRAHRKFSDEQVKNLGIISRLYEGDSDAFWALVEEYKAEGKQSEADWLLERWPDGKYQDIVGLCKVAKLEGEDGIIDNDYSLNAGRYVGVVIEDDGMTEEEFRTEMLSLNSEFAKLSAEAKDLESEIEKNLKELLG
>NC_014371.1|WP_013265449.1|784074_785298_+|restriction-endonuclease-subunit-S
MEYVKFKDVIINSQYGYTATETSQTEGTYKYLRITDIVPYYVNFDTVPFCKITEKDVSKYIVKEGDILIARTGATTGYNYVVPSGISNTVYASYLIRFIVDKKLVLPLFMKYVLKTQSYYGFINNYIGGSAQPGMNAKVFTKFNIPKLSLVTQQKIASILSSYDRLIENNTRRIRLLEQMAENLYKEWFVRFRFPEHENVEIVNGLPKGWKTIHIKELAQLKSGYAFKSEWFVEEGEAVAKIKDIGNILMDTSNFSYVDKENCIKAKKFLLTTGDLTIALTGATIGKISIVPKHKGNIYTNQRLGKFFLGDNPMEKLPFLYCLFKQESMVSNIVNLSNSSSAQPNISPEQIEKIKILGNHDIISMYNKTCNPLFSNILALYSQNQLLTRQRDLLLPRLMSGKLEVKS
>NC_014371.1|WP_013265602.1|785313_788514_+|type-I-restriction-endonuclease-subunit-R
MKSFISEDDIEQTLCTRLSQPEFGWKRIECDPSVEAQDDVSKTGRRNSSECILPAVFLTALERLNPQIDKSILAQVVADFRKDYTGKDMMDTNYKFYNYLRNGINVKVKKNGKDDFDIVRLIDFDNVENNDFHCVNQMWIKGRIRYRRPDVLLFVNGLPMVFIELKNSTVKIKEAYEKNLVSYREDIPNIFALNQICVLSNGMQTKLGAWNSKYEFFFDWLKVNDEHEKLDREHIAEYGLSIINLIDSLFRKERLLDYIENFIFFDNKRKKIIAKNHQYLGVNNLMKSVECREELKGKLGVFWHTQGSGKSYSMVMFVRKVRRKLKGNFTFLVITDRDDLDTQIHKTFVRSEVIGEKEECQPKNAAQLREFLSGNKPMVFTLIHKFQYDKTKKYPLLSERNDIFVLVDEAHRTQYKQLAENMHTGLPNANYIAFTGTPLLGSKRLTNQWFGDYVSEYNFAQAIEDGSTVRLYYSRRVPEVGLENNWLDSDIDKIVEEEELNDRERELLENSSSRILEVIKRDGRLDRIAQDIAHHFPRRGFLGKGMVVSVDKYTAVKMYEKVQHYWGEEKKALIKERNAAKTQEERDELTARLDYMNKVEMAVIISEEADEVEKFKAQGLDITVHRNKMNEITPEGKDIEDRFKDKDDPLSLVFVCAMWLTGFDVPSLSTLYLDKPMKGHTLMQAIARANRVYPGKSCGIVVDYVNVFKYMQQALSDYASNGEEGAEFPAKDITQLIATIDGCIEECDSFLQGLGIRLDKIITDGDTLDKLESLRLAYDKILEKDESKNRFKVMSNLMMNLHDAAKPEIFELGWKNEKFSPLSYLNGLFCNRIDDEKLRRAKEKMSYTLDDSVTVMVAEDKPQYSIHQSKVIDLSKLDIESIRKSINATPYKSMEIDNLRTFIETALEQLINKNCTRVPFSQRYKNIIDTYNAGGTENEDYYEKLLQLIDELKKEQGRSADMGLREEELEIYDLLIQGRKLTKEEEKEVILASKNLYNKLVEEKERLLVVDWYKDPQPKTKVLGLIQRSLDKDLPKTYDREVFSNKTNLLLDHFVDMAVQGYGWIS
>NC_014371.1|WP_013265601.1|788899_790045_-|DUF1735-domain-containing-protein
MNKHIFKHIAVAFAACCVVSCQDSESDLLKQKVYFDSNLYKVEMPDSGSTLGVDITSRLSNKQDGAVDVSYSLADSSLVALYNSKYGTDYVALKHQNVTFSKASSTIAAGSIYADKVSLTLNNLDQLAEGKNYMLPIKLHSSSTPVIDGEDVEYIILAKPVKITKAGDFYNKYISVKFPAGTYFKSFTYEALVHSIWWGSNCTIMGSEGLMIFRVGDVGGGISSGILQAAGRQHYEAPEKLSINKWYHVALTYDQATGKTVMYLNGTKWAESAWNISGFDPNADVGFNIGKIPGFPWGERPFYGYMSEVRVWSVARSENQIKQNMLSVDPKSDGLELYFKLNGSETVNGNKIKDSAKGIECTTGGLEFTTLAQPLTMKDLQ
>NC_014371.1|WP_013265322.1|790085_791204_-|endoglycosidase
MKNFKYISSLVLLCAGVLFCGCSKMTEVENEPYDHIGGYNTMNNAESEKYYADLRAYKQQAVNYGRPVAFGWYSNWSPAGTYRRGYLTSMPDSMDVVSMWSGAPNRFNITPEQKKDKEFVQKVKGTKLLEVTLLSYIGKGRTPDSVYTAVEKQAEKEGWANDQARVEEAKKKARWKFWGYEGVAGSDNHKEALARFAKALCDSLVANDWDGYDIDWEIGSGVFDMDGTLSTNADLVYLVKEMNKYIGPKSDPEHKGHRLICIDGHFGGLTEDLDGYVDYWIDQAYGRTTHFDYYGVDPKTIITTDNFESSFKSGGQLLRQAKSMPSKGYKGGVGAYRFDNDYDNTPNYKWMRQAIQINQQVFKERMGQTTQP
>NC_014371.1|WP_013265381.1|791221_792847_-|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein
MKTKAYKYIVGVLALSLFTACDFQKVNTNEFELLPEEGLMDGISIGGPITAMQKCVFPVGTQADGTSVANRYQTAYNLAADCWSGYFGQNNNWGGPNNLNYFLKDGWVASSYTESYSTVVPLWQDLKGKTETQFPEVFALAQILKISAWHKATDMFGPIPYKEAGKGLITVPYDSQEEVYKAMFKELSDAIEVLTKYADNGNSKLLPNADAVYAGDVHKWVVYANSLMLRLAMRVYYADAALSKKYALQAVNHSYGVMKTKDDEAKMERGASLEFKNNLDVLINQYNECRMGSSMLAYLGGYQDPRLPKYFNTSTVSQAVTVGTYGKYSGVPTGHDVSSNDAFRDSSRPAITSTTPTYWMRASEVYFLLAEAALHGFAVGGTAESLYEKGIEMSFEENGIASSEVADYMSSGLKPSAYSFHLTNPGVNVDVPAVTEATTAWSGTDEEKLEKIMIQKWIALYPNGQEAWTEYRRTGYPKLHSVVTNYSNGEIDSEVGIRRMRFPTNKSTSAEDIANLESARKLLRGGLDKAGTRLWWDNKNH
>NC_014371.1|WP_013265872.1|792853_795964_-|SusC/RagA-family-TonB-linked-outer-membrane-protein
MRMIHETKQKHLYFSVAFALSIALAPTSVYAVGNPVGSPDASMPQAVQQNGNHKVTGRVVDSAGEPLIGATIMVEGTKEGAVTDIDGNFTINTTSKAKLVISYVGYTTQTIPVGDKTTIDVTLKEVANTMNEVVVTALGIKRAEKALSYNVQSVGSNELTRNKDANFVNSLNGKVAGVSISKSASGVGGATRVIMRGAKSIEGDNNVLYVIDGIPIFNFSGGRDSGIMGEGRVSSEGIADLNPEDIESISVLAGPSAAALYGSNAANGAILITTKKGKEGRVDISFSSSADFSSPLLMPKFQNTYGNKLGSYESWGEKLATPSSYDPKKDFFRTGTNFINALTLNMGNEFNQTFASVATTNSRGIVPNNTYDRYNFTIRNTTRMFKNRVQLDLGASYIKQKDNNMVSQGEYWNPIVAAYLFPRGESFEGIKTFERYDNVRNFPTQYWPISDSRFANQNPYWTAYRNLAPDDKDRFMFNAGLTYNIFDWLSVAGRIRLDKTFITSERKIYASSFNYFAKEKGAYDYYDYKDHQTYIDAIANINKTFGKFSLAANVGYSYSDYASLTRGYGGNLVLVPNKFSLNNINPTDSKIREAGGDSKVRNVAAFASAELGWRSMVYLTLTGRNDWNSRLVNSSEESFFYPSVGLSGIISEMTKLPSFISYLKVRGSYTEVGSPVSRSGMTPGTITTPIVGGSLKSTDIYPFTDYKAERTKSYEFGLTARFWKKLSFDFTWYKSNTYNQTFIGELPESSGYKAVYLQAGNVENRGVEMALGYSDNFGGLQWNSSLVYSKNVNEIKEMVKDYHHPLSPKPINIPEVSKDNGRVLLKVGGSINDIYARKVLAKDNQGFVNVSPSGGMNLETVEPIYLGKTTPDFTMGWNNNFTYKNFGLSFLINARVGGIVTSSTQALLDRFGVSKASADARDAGGVMIPNQGLYDAKKYYTLVATGENDLAGYYTYSATNVRLQELTLSYKFNSKLFNNVIKDLTLSFVATNPWMIYCKAPFDPELTASTGTYGQGNDYFMQPSLKSYGFSVKFKF
>NC_014371.1|WP_004359657.1|796317_797421_-|Mrp/NBP35-family-ATP-binding-protein
MTLYPKLITDALEKVIYPGTKKNIIESEMLADTPSINGNKVSFTLIFPRETDPFLKSTIKAAEAQIHYSVGKEVEVTITTEFKNAPRPEVGKLLPQVKNIIAVSSGKGGVGKSTVSANLAIALARLGYKVGLLDTDIFGPSMPKMFGVEDARPYGVEKDGRQLIEPVEKYGVKLLSIGFFVNPDTATLWRGSMATSALKQLIADADWGELDYFILDTPPGTSDIHLTLMQTLAITGAVIVSTPQNVALADARKGIDMYRNDKVNIPILGLVENMAWFTPAELPENKYYIFGKDGCKNLAKELGCPLLAQIPIVQSICENGDNGTPAASQVDTITGQSFLSLAQSVVTVVNRRNKEQAPTKIVDVKNG
>NC_014371.1|WP_013265397.1|797551_797929_-|hypothetical-protein
MGRNKFAEDEIKEIAKLLRLKNAGNRAKQKLVRHDLRTIYEFNISDFNEPGKAFGEEELQGAIQRGAIQILDDATIADMKAKRARDKARDEATREQQAIEAGEMTDWKAVAKEWEEWENSQNNGN
>NC_014371.1|WP_044046079.1|799955_800471_+|hypothetical-protein
MILRNTKRIINYCVLMIGLGVWGSCNSKSQHVLLPVDNVKSYKICENNDTTTIFEEREEESEEVIKFYKEGSEIFTSDYGGRKELLMSTTEMLDTVYSGNTYCREHRILIKKENSNLFSTSIYNIIIHPVLVLTIYYDHSYNIKAIRNWFAFTTYESEHISIPLISRPVKY

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Crispr_ID: NC_014371_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014371_3

788674-788827

Orphan

Consensus_repeat	Method
AAAACTCATATCATAAAGTTCAAAGTTCAAACATCAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014371_3

>merge|NC_014371|3|788674-788827|CRISPRCasFinder
AAAACTCATATCATAAAGTTCAAAGTTCAAACATCAATGTTCAAAGGATAAAAAACTCATATCATAAAGTTCAAAGTTCAAACATCAATGTTCAAAGGATAAAAGAGTTCAAAGGATAAAACTCATATCATAAAGTTCAAAGTTCAAACCTCAA

>NC_014371|3|3|788674-788827|CRISPRCasFinder
AAAACTCATATCATAAAGTTCAAAGTTCAAACATCAA	TGTTCAAAGGATAAAAAACTCATATCATAAAGTTCAAAGTTCAAACATCAATGTTCAAAGGATAAAAGAGTTCAAAGGAT
AAAACTCATATCATAAAGTTCAAAGTTCAAACCTCAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_014371.1\|WP_013265545.1\|772633_774253_+\|BACON-domain-containing-protein	unknown	unknown	gnl\|CDD\|271342
NC_014371.1\|WP_013265322.1\|790085_791204_-\|endoglycosidase	unknown	unknown	gnl\|CDD\|119359
NC_014371.1\|WP_013265449.1\|784074_785298_+\|restriction-endonuclease-subunit-S	unknown	unknown	gnl\|CDD\|341202
NC_014371.1\|WP_013265887.1\|779672_781247_+\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_013265123.1\|782384_784061_+\|type-I-restriction-modification-system-subunit-M	unknown	unknown	gnl\|CDD\|280533
NC_014371.1\|WP_013265120.1\|801770_802115_+\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_013265602.1\|785313_788514_+\|type-I-restriction-endonuclease-subunit-R	unknown	unknown	gnl\|CDD\|223683
NC_014371.1\|WP_013265397.1\|797551_797929_-\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_044046077.1\|778674_779628_+\|PorV/PorQ-family-protein	unknown	unknown	unknown
NC_014371.1\|WP_013265601.1\|788899_790045_-\|DUF1735-domain-containing-protein	unknown	unknown	gnl\|CDD\|378016
NC_014371.1\|WP_013265714.1\|770886_771699_+\|PepSY-domain-containing-protein	unknown	unknown	gnl\|CDD\|377164
NC_014371.1\|WP_013265381.1\|791221_792847_-\|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein	unknown	unknown	gnl\|CDD\|372283
NC_014371.1\|WP_013265837.1\|775906_778663_+\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173811
NC_014371.1\|WP_013265872.1\|792853_795964_-\|SusC/RagA-family-TonB-linked-outer-membrane-protein	unknown	unknown	gnl\|CDD\|274948
NC_014371.1\|WP_013265441.1\|769954_770680_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|187608
NC_014371.1\|WP_044046079.1\|799955_800471_+\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_013265519.1\|774289_775891_+\|BACON-domain-containing-protein	unknown	unknown	gnl\|CDD\|271342
NC_014371.1\|WP_036925686.1\|801463_801763_+\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_004359657.1\|796317_797421_-\|Mrp/NBP35-family-ATP-binding-protein	unknown	unknown	gnl\|CDD\|378455
NC_014371.1\|WP_146160291.1\|800582_800813_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_014371.1\|WP_013265545.1\|772633_774253_+\|BACON-domain-containing-protein	gnl\|CDD\|271342	cd14948, BACON, Bacteroidetes-Associated Carbohydrate-binding (putative) Often N-terminal (BACON) domain. The BACON domain is found in diverse domain architectures and accociated with a wide variety of domains, including carbohydrate-active enzymes and proteases. It was named for its suggested function of carbohydrate binding; the latter was inferred from domain architectures, sequence conservation, and phyletic distribution. However, recent experimental data suggest that its primary function in Bacteroides ovatus endo-xyloglucanase BoGH5A is to distance the catalytic module from the cell surface and confer additional mobility to the catalytic domain for attack of the polysaccharide. No evidence for a direct role in carbohydrate binding could be found in that case. The large majority of BACON domains are found in Bacteroidetes.	6.54743e-12
NC_014371.1\|WP_013265449.1\|784074_785298_+\|restriction-endonuclease-subunit-S	gnl\|CDD\|341202	cd17521, RMtype1_S_Sau13435ORF2165P_TRD2-CR2_like, Type I restriction-modification system specificity (S) subunit TRD-CR, similar to Staphylococcus aureus NCTC 13435 S subunit (S.Sau13435ORF2165P) TRD2-CR2, Escherichia coli E24377A S subunit (S.EcoE24377ORF286P) TRD1-CR1 and Pseudoalteromonas species P1-13-1a S. subunit (S.Psp1bORF2093P) TRD2-CR2. Staphylococcus aureus NCTC 13435 S subunit (S.Sau13435ORF2165P) recognizes 5'... TCTANNNNNNRTTC ... 3', and the recognition sequences of Escherichia coli E24377A S subunit (S.EcoE24377ORF286P) and Pseudoalteromonas species P1-13-1a S subunit (S.Psp1bORF2093P) are undetermined. The restriction-modification (RM) system S subunit generally consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. For example, Staphylococcus aureus NCTC 13435 S subunit (S.Sau13435ORF2165P) TRD1 recognizes TCTA/TAGA, and -TRD2 recognizes GAAY/RTTC. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one heteromeric enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. In addition, this family includes RMtype1_S_TRD-CR_like domains of various putative Helicobacter type II restriction enzymes and methyltransferases, such as Hci611ORFHP and HfeORF12890P.	1.95866e-71
NC_014371.1\|WP_013265602.1\|785313_788514_+\|type-I-restriction-endonuclease-subunit-R	gnl\|CDD\|223683	COG0610, COG0610, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms].	4.22971e-142
NC_014371.1\|WP_013265123.1\|782384_784061_+\|type-I-restriction-modification-system-subunit-M	gnl\|CDD\|280533	pfam02384, N6_Mtase, N-6 DNA Methylase. Restriction-modification (R-M) systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The R-M system is a complex containing three polypeptides: M (this family), S (pfam01420), and R. This family consists of N-6 adenine-specific DNA methylase EC:2.1.1.72 from Type I and Type IC restriction systems. These methylases have the same sequence specificity as their corresponding restriction enzymes.	1.95381e-85
NC_014371.1\|WP_013265601.1\|788899_790045_-\|DUF1735-domain-containing-protein	gnl\|CDD\|378016	pfam08522, DUF1735, Domain of unknown function (DUF1735). This domain of unknown function is found in a number of bacterial proteins including acylhydrolases. The structure of this domain has a beta-sandwich fold.	2.2566e-16
NC_014371.1\|WP_013265714.1\|770886_771699_+\|PepSY-domain-containing-protein	gnl\|CDD\|377164	pfam03929, PepSY_TM, PepSY-associated TM region. The PepSY_TM family is so named because it is an alignment of up to five transmembranes helices found in bacterial species some of which carry a nested PepSY domain, pfam03413.	1.27613e-34
NC_014371.1\|WP_013265837.1\|775906_778663_+\|S8-family-serine-peptidase	gnl\|CDD\|173811	cd07485, Peptidases_S8_Fervidolysin_like, Peptidase S8 family domain in Fervidolysin. Fervidolysin found in Fervidobacterium pennivorans is an extracellular subtilisin-like keratinase. It is contains a signal peptide, a propeptide, and a catalytic region. The tertiary structure of fervidolysin is similar to that of subtilisin. It contains a Asp/His/Ser catalytic triad and is a member of the peptidase S8 (subtilisin and kexin) family. The catalytic triad is similar to that found in trypsin-like proteases, but it does not share their three-dimensional structure and are not homologous to trypsin. Serine acts as a nucleophile, aspartate as an electrophile, and histidine as a base. The S53 family contains a catalytic triad Glu/Asp/Ser with an additional acidic residue Asp in the oxyanion hole, similar to that of subtilisin. The serine residue here is the nucleophilic equivalent of the serine residue in the S8 family, while glutamic acid has the same role here as the histidine base. However, the aspartic acid residue that acts as an electrophile is quite different. In S53, it follows glutamic acid, while in S8 it precedes histidine. The stability of these enzymes may be enhanced by calcium; some members have been shown to bind up to 4 ions via binding sites with different affinity. There is a great diversity in the characteristics of their members: some contain disulfide bonds, some are intracellular while others are extracellular, some function at extreme temperatures, and others at high or low pH values.	1.25562e-83
NC_014371.1\|WP_013265872.1\|792853_795964_-\|SusC/RagA-family-TonB-linked-outer-membrane-protein	gnl\|CDD\|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
NC_014371.1\|WP_013265519.1\|774289_775891_+\|BACON-domain-containing-protein	gnl\|CDD\|271342	cd14948, BACON, Bacteroidetes-Associated Carbohydrate-binding (putative) Often N-terminal (BACON) domain. The BACON domain is found in diverse domain architectures and accociated with a wide variety of domains, including carbohydrate-active enzymes and proteases. It was named for its suggested function of carbohydrate binding; the latter was inferred from domain architectures, sequence conservation, and phyletic distribution. However, recent experimental data suggest that its primary function in Bacteroides ovatus endo-xyloglucanase BoGH5A is to distance the catalytic module from the cell surface and confer additional mobility to the catalytic domain for attack of the polysaccharide. No evidence for a direct role in carbohydrate binding could be found in that case. The large majority of BACON domains are found in Bacteroidetes.	3.84982e-16
NC_014371.1\|WP_013265381.1\|791221_792847_-\|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein	gnl\|CDD\|372283	pfam12741, SusD-like, Susd and RagB outer membrane lipoprotein. This is a family of SusD-like proteins, one member of which, BT1043, is an outer membrane lipoprotein involved in host glycan metabolism. The structures of this and SusD-homologs in the family are dominated by tetratrico peptide repeats that may facilitate association with outer membrane beta-barrel transporters required for glycan uptake. The structure of BT1043 complexed with N-acetyllactosamine reveals that recognition is mediated via hydrogen bonding interactions with the reducing end of beta-N-acetylglucosamine, suggesting a role in binding glycans liberated from the mucin polypeptide. Mammalian distal gut bacteria have an expanded capacity to utilize glycans. In the absence of dietary sources, some species rely on host-derived mucosal glycans. The ability of Bacteroides thetaiotaomicron, a prominent human gut symbiont, to forage host glycans contributes to both its ability to persist within an individual host and its ability to be transmitted naturally to new hosts at birth.	0
NC_014371.1\|WP_013265322.1\|790085_791204_-\|endoglycosidase	gnl\|CDD\|119359	cd06542, GH18_EndoS-like, Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain. Some members also have an additional C-terminal glycosyl hydrolase family 20 (GH20) domain while others have an N-terminal domain of unknown function (pfam08522). Members of this family include endo-beta-N-acetylglucosaminidase S (EndoS) from Streptococcus pyogenes, EndoF1, EndoF2, EndoF3, and EndoH from Flavobacterium meningosepticum, and EndoE from Enterococcus faecalis. EndoS is a secreted endoglycosidase from Streptococcus pyogenes that specifically hydrolyzes the glycan on human IgG between two core N-acetylglucosamine residues. EndoE is a secreted endoglycosidase, encoded by the ndoE gene in Enterococcus faecalis, that hydrolyzes the glycan on human RNase B.	3.54753e-38
NC_014371.1\|WP_004359657.1\|796317_797421_-\|Mrp/NBP35-family-ATP-binding-protein	gnl\|CDD\|378455	pfam10609, ParA, NUBPL iron-transfer P-loop NTPase. This family contains ATPases involved in plasmid partitioning. It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits.	1.83825e-134
NC_014371.1\|WP_013265441.1\|769954_770680_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|187608	cd05350, SDR_c6, classical (c) SDR, subgroup 6. These proteins are members of the classical SDR family, with a canonical active site tetrad and a fairly well conserved typical Gly-rich NAD-binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	3.73694e-47

>NC_014371.1|WP_013265602.1|785313_788514_+|type-I-restriction-endonuclease-subunit-R
MKSFISEDDIEQTLCTRLSQPEFGWKRIECDPSVEAQDDVSKTGRRNSSECILPAVFLTALERLNPQIDKSILAQVVADFRKDYTGKDMMDTNYKFYNYLRNGINVKVKKNGKDDFDIVRLIDFDNVENNDFHCVNQMWIKGRIRYRRPDVLLFVNGLPMVFIELKNSTVKIKEAYEKNLVSYREDIPNIFALNQICVLSNGMQTKLGAWNSKYEFFFDWLKVNDEHEKLDREHIAEYGLSIINLIDSLFRKERLLDYIENFIFFDNKRKKIIAKNHQYLGVNNLMKSVECREELKGKLGVFWHTQGSGKSYSMVMFVRKVRRKLKGNFTFLVITDRDDLDTQIHKTFVRSEVIGEKEECQPKNAAQLREFLSGNKPMVFTLIHKFQYDKTKKYPLLSERNDIFVLVDEAHRTQYKQLAENMHTGLPNANYIAFTGTPLLGSKRLTNQWFGDYVSEYNFAQAIEDGSTVRLYYSRRVPEVGLENNWLDSDIDKIVEEEELNDRERELLENSSSRILEVIKRDGRLDRIAQDIAHHFPRRGFLGKGMVVSVDKYTAVKMYEKVQHYWGEEKKALIKERNAAKTQEERDELTARLDYMNKVEMAVIISEEADEVEKFKAQGLDITVHRNKMNEITPEGKDIEDRFKDKDDPLSLVFVCAMWLTGFDVPSLSTLYLDKPMKGHTLMQAIARANRVYPGKSCGIVVDYVNVFKYMQQALSDYASNGEEGAEFPAKDITQLIATIDGCIEECDSFLQGLGIRLDKIITDGDTLDKLESLRLAYDKILEKDESKNRFKVMSNLMMNLHDAAKPEIFELGWKNEKFSPLSYLNGLFCNRIDDEKLRRAKEKMSYTLDDSVTVMVAEDKPQYSIHQSKVIDLSKLDIESIRKSINATPYKSMEIDNLRTFIETALEQLINKNCTRVPFSQRYKNIIDTYNAGGTENEDYYEKLLQLIDELKKEQGRSADMGLREEELEIYDLLIQGRKLTKEEEKEVILASKNLYNKLVEEKERLLVVDWYKDPQPKTKVLGLIQRSLDKDLPKTYDREVFSNKTNLLLDHFVDMAVQGYGWIS
>NC_014371.1|WP_013265449.1|784074_785298_+|restriction-endonuclease-subunit-S
MEYVKFKDVIINSQYGYTATETSQTEGTYKYLRITDIVPYYVNFDTVPFCKITEKDVSKYIVKEGDILIARTGATTGYNYVVPSGISNTVYASYLIRFIVDKKLVLPLFMKYVLKTQSYYGFINNYIGGSAQPGMNAKVFTKFNIPKLSLVTQQKIASILSSYDRLIENNTRRIRLLEQMAENLYKEWFVRFRFPEHENVEIVNGLPKGWKTIHIKELAQLKSGYAFKSEWFVEEGEAVAKIKDIGNILMDTSNFSYVDKENCIKAKKFLLTTGDLTIALTGATIGKISIVPKHKGNIYTNQRLGKFFLGDNPMEKLPFLYCLFKQESMVSNIVNLSNSSSAQPNISPEQIEKIKILGNHDIISMYNKTCNPLFSNILALYSQNQLLTRQRDLLLPRLMSGKLEVKS
>NC_014371.1|WP_013265123.1|782384_784061_+|type-I-restriction-modification-system-subunit-M
MTSTELKDLEGRLWQSADMLRAGAHLAANKYSQPILGLIFLRYADVLFKQHKEAIDTAYNEYKGTRMERSYKDIAIEKCGFFLPECAYFDYLNDAPDDAQKALLVKAAMEAIEHENPRMDGVLPKEVYGQLVPEEEPELLSRIVRVFKDIPENISIDIFGQIYEYFLGNFALAEGQGGGAFYTPASVVQYMVEVLQPATGDKKFLDPACGSGGMFVQAARYMHRHNTSNEQMMNFRCYGVEKEPDTVKLAKMNLLLNNVRGEIMEANSFYSDPYNAVGQFDYVMANPPFNVDEVVVERVTDDARFNTYGVPRNKTKSAKKASDKKETVPNANYLWIGYFATALNEQGKAALVMANSASDAGGSELEIRKKMIEDGIISQMVTLPSNMFSTVTLPATLWFFNKKRPKKDEILFIDARNIFTQVDRAHRKFSDEQVKNLGIISRLYEGDSDAFWALVEEYKAEGKQSEADWLLERWPDGKYQDIVGLCKVAKLEGEDGIIDNDYSLNAGRYVGVVIEDDGMTEEEFRTEMLSLNSEFAKLSAEAKDLESEIEKNLKELLG
>NC_014371.1|WP_013265887.1|779672_781247_+|hypothetical-protein
MKRTLFSICALVLSLTASAQIIKDTPKGKLIENLYRSSKSWVKKGWTGVQPGRYEGLVSKIVIGEDGCIYIYNPLSGLDSKSWLKLERQPDGKYRAKLPQDILTDDYGGDDDEEESSERTISLTRLVSSDDGKNYEPIGANNYVDFTVEGRTLKMSGMGQKKQIWGASFNNKWERNYGGDWALTIEPLKEQLITPPATATKSQYTVTSKSDPSPRIVEVMTNNNDIYVKGLFKAEKLANVWVKLTKQGDKAVMPTNQYLGITKKTDFKKYDSDKSEYHTFAAAFESETKAAENLEFSIDATGKLTASKILRTSLGRASNDNITGEDYIESYEGLTLTPYVQKEVGAPATPEYFYLTSTPNYDNTSNEIKLAFYVKNADINGNVLDPEKMYYNVYINGSTEPFKFKKSASQYNDMHEEEMTNIPFNYKDKRNYDFKVIDNLRILHFYDSSITRLKVVMVYESDGKKYSSEPMVASLTTDGIESANFNKTTTEKYYTVDGRQIQKLQKGLNIIKSSDGTTRKVVVK
>NC_014371.1|WP_044046077.1|778674_779628_+|PorV/PorQ-family-protein
MNTKHIILMACAALLGATQANAQGQDLSILTANTDARTAAMGNASAAAEGMYLYNNPAAFFATDKKFTADASASLFEKAEGADGTFGIYALSAGYKLAKRHAVFVGFRYAGGLSLKGSDLLGNPTKDYKPYNWTLDLGYTYFLGKGFATYATGSLIYSHLSKNATGAVFSVGGAYQNNELTLANKPANLMLDAKVGAIGPQLDYGNKHKTTLPTYLAVGGALSVEVAEKHQVAAALSSRYFFQPSEAKLFMLGGGLEYTYNKMVSVRAGYEYGDHDLSHVTMGAGFKYHGLRLNGAYNLKTADTGSSYCTIGIGYDF
>NC_014371.1|WP_013265837.1|775906_778663_+|S8-family-serine-peptidase
MRKSIIYLCACALSGMMVTTSCQDNLDSDAGVSNTRSVNIDKDLFAIKGCINVKLAKGTNQAIPTTRSGSVEMQSVPSAMTSAMQYSGAYKMERVFKPAGIYEARTVAEGLDRWYTIYFDKSKDVAAVLDQFKKAEGVECAEQVLPMARPTVKMTPYSPSGASMQATASTFDDPLLAKQWHYYNDGSVNARAKKGADCNVKPVWEKYTTGKKNVIVAVVDGGIDITHEDLKDNLYVNEKEKNGQPNVDDDGNGFVDDIYGYNFVTAKDVVGGTIEPDDGGHGTHVAGTVAARNNNGKGVAGIAGGDGSPDSGVRLLSCQIFRNKDEQGDAAAAIKYAADNGAVICQNSWGYSSTAGVTSMPQLLKEAVDYFIKMAGCDANGNQRPDSPMKGGVVMFAAGNENKEFSAYPACYAPTVSVAAMAWDFSKASYSNYAKWVTITAPGGDQDRFGTEAGVLSTVPKKKVASGYAYFQGTSMACPHVSGIAALIASYFGRQGFTNEELKSRLITAYRPYNIDEQNPTYKGKLGKGYIDAEAAFETDTKIAPEKVGTLTLKPDFVDINAEWSIAKDEDKTAAFYRLYIAQGELTADKLKDMTYREINGMGHSLGETLKYDFDDLKDNTTYSVAVVAVDRWGNLSEPMIQKCTTRLNHAPEATNFPTEAIEVMENDRKSFSFNVADPDGHNWDIKATGETKGVSYTVKGNTVTVNLVPVLEAGSYNCTFILSDDLGAKAEKSFTFKIVKYIPPQLTKPFENYIIGLDEGVVTIPLTGHYTHSGNTQLTYKATAANGSIATATISNDNLQLKGMAKGVTRISIAATDGRETSSDGSFQVRVVEKKSAPVYAVYPIPVQRDIHTLLNPEVKQAELVISSTVGERLMKATVTPDKNNVATLDLSKLNPGTYKLTVYTSKGNHTQMFIKR
>NC_014371.1|WP_013265519.1|774289_775891_+|BACON-domain-containing-protein
MRIINIHKLLQFSLLYLLLGIAVGCAENDSFDQPYLNVSEKEISFSNQIGEKTITVNTNCKEWMATTPKAWVHLSQSGNEIAVHVDPNTTGMERSSYILVDGGLAVQKIMVSQSAADITLNLNNGEVILPQAGGTTTVDLKMDATSYDLTQSEQPEWMQVIKKKHGLKFISKPNYSTTERTTKLTIAFAGKNHEVVVKQPGVATFILACNPGNPYSLHKMMDYEYRRGSFLTEYGGPDEVNGIFEESYFFKTPSPLFKDVVYVHDTKHSVPTRIYTRSLTREGVNAVKSQAFQEFMRANGYTRDEKDTNHYVNIKEAFTMDVDIREENNSVVLFFYQMHTQDRSYPTFSSLDLGPVDLLNKTDKKISDVEAYETGKNSEEMKRQMSKSNEVEAILYKTNDPTLIARTYFFYLHNDAAVPQEKAGSVEQYSLFYSQPNLGIWQYGNEWFVTHEFDKLLTANNFEFVGYNGKHHVYARRSDYLTLAISGGEYADVNNGKAVMQITVLYKPTVFAGSKEQRLAKVERMLKQYNPKK
>NC_014371.1|WP_013265545.1|772633_774253_+|BACON-domain-containing-protein
MELKKTLYSLMLGGILLCLFSCAKEDEFEMPTLVLSENSIAFDKGVSERNISVTTNQNSWIASSPQEGDWLSLVQDGNVLKVKVTENKIGTERTSYVLVNANGASGKIAVTQSAADVTLDVVPNAIYLPQTGGEKTIDITTNSSVYDVTTSEEVSWLKIVKSEEEIKLIAERNDTYQKREVKLYAKSGSVIREIVVSQSGIQRYLLPIHPGVPQDEHKIMDFELGRGSYLREYQAAMPAYGLEETYTFITASPIFTLIQYCSTDGINPSQIIMIGDGRKAIDAVKDKAFDKFLTDNGYVRSNSQSDREYTNDKDLLSLKVYISEKENNEGVNLTFTPIMKQNGEYKTFSKLPFYPLELLQKDNVKLAQIEQYEQKAGSTEEERSLNEHKNTEVSQIQYKLKASTDPSAAYGRIHIFYTTDKDGDAPDNLGSVQIGALLFKDTNLGVWKYGTKWVATKEIKKVLGDEGFSFLRTSGNNHFFVRESDHLVIDVTCVLDNAMPVLALLYSYDPSVSGASSKAIKTQAKMIRNFAAAKKALKF
>NC_014371.1|WP_013265714.1|770886_771699_+|PepSY-domain-containing-protein
MRKFCLKIHRWFALPLGVIMAILCFSGLAILLIKDLAPLFDMNAKEMPIYTIVVRLHRWLFMKPENAHEGGQSLGRILTAVSAICMSIVLLSGVVIWWPKTKKALKSRLTVSTNKGFRRFVYDSHVSLGIYVFIFLFLMALTGPVFSFGWYRAGMSKLFGQPMPPKEMKMQQPKDGMKQGGTNDKAFAPTDASQMKGQPQAHKEGAKDMKGDQHGKKPKGGKLFKQLHTGTWGGWFSRVLYAIAALIGGFLPISGYYLWWKRRSAKKKKA
>NC_014371.1|WP_013265441.1|769954_770680_+|SDR-family-NAD(P)-dependent-oxidoreductase
MKKAIVVGASSGIGHEVARLLIAEGWAVGVAARRIDKLTDLQAMAPERVYTVQIDVTNEDAETSLLQLIERMNGIDLYFHAAGIGWQNPSLNADIELKTMETNAVGFTRMIGCAYRYFANKGGGHIACITSIAGTKGLGPAPAYSATKAMQNTYLQALEQLAACKHHNIHFTDIRPGFVDTPLLAGTSHLPMLMTTKKVARSIIKAINSRRHICVIDSRWCVLTYLWRHIPNWIWRRMKLC
>NC_014371.1|WP_013265601.1|788899_790045_-|DUF1735-domain-containing-protein
MNKHIFKHIAVAFAACCVVSCQDSESDLLKQKVYFDSNLYKVEMPDSGSTLGVDITSRLSNKQDGAVDVSYSLADSSLVALYNSKYGTDYVALKHQNVTFSKASSTIAAGSIYADKVSLTLNNLDQLAEGKNYMLPIKLHSSSTPVIDGEDVEYIILAKPVKITKAGDFYNKYISVKFPAGTYFKSFTYEALVHSIWWGSNCTIMGSEGLMIFRVGDVGGGISSGILQAAGRQHYEAPEKLSINKWYHVALTYDQATGKTVMYLNGTKWAESAWNISGFDPNADVGFNIGKIPGFPWGERPFYGYMSEVRVWSVARSENQIKQNMLSVDPKSDGLELYFKLNGSETVNGNKIKDSAKGIECTTGGLEFTTLAQPLTMKDLQ
>NC_014371.1|WP_013265322.1|790085_791204_-|endoglycosidase
MKNFKYISSLVLLCAGVLFCGCSKMTEVENEPYDHIGGYNTMNNAESEKYYADLRAYKQQAVNYGRPVAFGWYSNWSPAGTYRRGYLTSMPDSMDVVSMWSGAPNRFNITPEQKKDKEFVQKVKGTKLLEVTLLSYIGKGRTPDSVYTAVEKQAEKEGWANDQARVEEAKKKARWKFWGYEGVAGSDNHKEALARFAKALCDSLVANDWDGYDIDWEIGSGVFDMDGTLSTNADLVYLVKEMNKYIGPKSDPEHKGHRLICIDGHFGGLTEDLDGYVDYWIDQAYGRTTHFDYYGVDPKTIITTDNFESSFKSGGQLLRQAKSMPSKGYKGGVGAYRFDNDYDNTPNYKWMRQAIQINQQVFKERMGQTTQP
>NC_014371.1|WP_013265381.1|791221_792847_-|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein
MKTKAYKYIVGVLALSLFTACDFQKVNTNEFELLPEEGLMDGISIGGPITAMQKCVFPVGTQADGTSVANRYQTAYNLAADCWSGYFGQNNNWGGPNNLNYFLKDGWVASSYTESYSTVVPLWQDLKGKTETQFPEVFALAQILKISAWHKATDMFGPIPYKEAGKGLITVPYDSQEEVYKAMFKELSDAIEVLTKYADNGNSKLLPNADAVYAGDVHKWVVYANSLMLRLAMRVYYADAALSKKYALQAVNHSYGVMKTKDDEAKMERGASLEFKNNLDVLINQYNECRMGSSMLAYLGGYQDPRLPKYFNTSTVSQAVTVGTYGKYSGVPTGHDVSSNDAFRDSSRPAITSTTPTYWMRASEVYFLLAEAALHGFAVGGTAESLYEKGIEMSFEENGIASSEVADYMSSGLKPSAYSFHLTNPGVNVDVPAVTEATTAWSGTDEEKLEKIMIQKWIALYPNGQEAWTEYRRTGYPKLHSVVTNYSNGEIDSEVGIRRMRFPTNKSTSAEDIANLESARKLLRGGLDKAGTRLWWDNKNH
>NC_014371.1|WP_013265872.1|792853_795964_-|SusC/RagA-family-TonB-linked-outer-membrane-protein
MRMIHETKQKHLYFSVAFALSIALAPTSVYAVGNPVGSPDASMPQAVQQNGNHKVTGRVVDSAGEPLIGATIMVEGTKEGAVTDIDGNFTINTTSKAKLVISYVGYTTQTIPVGDKTTIDVTLKEVANTMNEVVVTALGIKRAEKALSYNVQSVGSNELTRNKDANFVNSLNGKVAGVSISKSASGVGGATRVIMRGAKSIEGDNNVLYVIDGIPIFNFSGGRDSGIMGEGRVSSEGIADLNPEDIESISVLAGPSAAALYGSNAANGAILITTKKGKEGRVDISFSSSADFSSPLLMPKFQNTYGNKLGSYESWGEKLATPSSYDPKKDFFRTGTNFINALTLNMGNEFNQTFASVATTNSRGIVPNNTYDRYNFTIRNTTRMFKNRVQLDLGASYIKQKDNNMVSQGEYWNPIVAAYLFPRGESFEGIKTFERYDNVRNFPTQYWPISDSRFANQNPYWTAYRNLAPDDKDRFMFNAGLTYNIFDWLSVAGRIRLDKTFITSERKIYASSFNYFAKEKGAYDYYDYKDHQTYIDAIANINKTFGKFSLAANVGYSYSDYASLTRGYGGNLVLVPNKFSLNNINPTDSKIREAGGDSKVRNVAAFASAELGWRSMVYLTLTGRNDWNSRLVNSSEESFFYPSVGLSGIISEMTKLPSFISYLKVRGSYTEVGSPVSRSGMTPGTITTPIVGGSLKSTDIYPFTDYKAERTKSYEFGLTARFWKKLSFDFTWYKSNTYNQTFIGELPESSGYKAVYLQAGNVENRGVEMALGYSDNFGGLQWNSSLVYSKNVNEIKEMVKDYHHPLSPKPINIPEVSKDNGRVLLKVGGSINDIYARKVLAKDNQGFVNVSPSGGMNLETVEPIYLGKTTPDFTMGWNNNFTYKNFGLSFLINARVGGIVTSSTQALLDRFGVSKASADARDAGGVMIPNQGLYDAKKYYTLVATGENDLAGYYTYSATNVRLQELTLSYKFNSKLFNNVIKDLTLSFVATNPWMIYCKAPFDPELTASTGTYGQGNDYFMQPSLKSYGFSVKFKF
>NC_014371.1|WP_004359657.1|796317_797421_-|Mrp/NBP35-family-ATP-binding-protein
MTLYPKLITDALEKVIYPGTKKNIIESEMLADTPSINGNKVSFTLIFPRETDPFLKSTIKAAEAQIHYSVGKEVEVTITTEFKNAPRPEVGKLLPQVKNIIAVSSGKGGVGKSTVSANLAIALARLGYKVGLLDTDIFGPSMPKMFGVEDARPYGVEKDGRQLIEPVEKYGVKLLSIGFFVNPDTATLWRGSMATSALKQLIADADWGELDYFILDTPPGTSDIHLTLMQTLAITGAVIVSTPQNVALADARKGIDMYRNDKVNIPILGLVENMAWFTPAELPENKYYIFGKDGCKNLAKELGCPLLAQIPIVQSICENGDNGTPAASQVDTITGQSFLSLAQSVVTVVNRRNKEQAPTKIVDVKNG
>NC_014371.1|WP_013265397.1|797551_797929_-|hypothetical-protein
MGRNKFAEDEIKEIAKLLRLKNAGNRAKQKLVRHDLRTIYEFNISDFNEPGKAFGEEELQGAIQRGAIQILDDATIADMKAKRARDKARDEATREQQAIEAGEMTDWKAVAKEWEEWENSQNNGN
>NC_014371.1|WP_044046079.1|799955_800471_+|hypothetical-protein
MILRNTKRIINYCVLMIGLGVWGSCNSKSQHVLLPVDNVKSYKICENNDTTTIFEEREEESEEVIKFYKEGSEIFTSDYGGRKELLMSTTEMLDTVYSGNTYCREHRILIKKENSNLFSTSIYNIIIHPVLVLTIYYDHSYNIKAIRNWFAFTTYESEHISIPLISRPVKY
>NC_014371.1|WP_146160291.1|800582_800813_+|hypothetical-protein
MKKKSSFDNGLRLRILTRHQAPALGAPLSILSTGKMDVRQGVNLKLSGVERKCRLHTVFDFAVIPVTSLLTLTYYL
>NC_014371.1|WP_036925686.1|801463_801763_+|hypothetical-protein
MKIKNILAVFIIVGGISYALYFSLVTDVLLKYGETIHTKAIIEERLTGKTSDPVLRYRFLYENQAYIGFVSETSRLHVSDTINIVFLKSRPSINKPLIK
>NC_014371.1|WP_013265120.1|801770_802115_+|hypothetical-protein
MKKNLLFSFDDEITTGVYYDIDGHKIVVYFAAYYDNGRFVEKKCQLIIEKWEYAKSKLSVDNRYKDLEDHIGIISMILDMHIADKKLFLTVNTLDGQYVDLLFYNCNVKIEDIS

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Crispr_ID: NC_014371_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014371_4

1009226-1009316

Orphan

Consensus_repeat	Method
AGTTGACAAGTGAACAAGTTGCTTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014371_4

>merge|NC_014371|4|1009226-1009316|CRISPRCasFinder
AGTTGACGAGTAAACGAGTTGACAAGTGAACAAGTTGCTTGAGAAGAAGACAAAGGAACTTTGAAAAATTAACAAGTGAACAAGTTGACAA

>NC_014371|4|4|1009226-1009316|CRISPRCasFinder
AGTTGACGAGTAAACGAGTTGACAA	GTGAACAAGTTGCTTGAGAAGAAGACAAAGGAACTTTGAAA
AATTAACAAGTGAACAAGTTGACAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_014371.1\|WP_013265208.1\|1021102_1021585_-\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_013265446.1\|1002328_1003411_-\|tRNA-2-thiouridine(34)-synthase-MnmA	unknown	unknown	gnl\|CDD\|234664
NC_014371.1\|WP_044046112.1\|1018121_1018829_+\|glycosyl-hydrolase-family-25	unknown	unknown	gnl\|CDD\|119375
NC_014371.1\|WP_013265765.1\|984753_986466_-\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	unknown	unknown	gnl\|CDD\|373012
NC_014371.1\|WP_013265273.1\|1016432_1017125_+\|(d)CMP-kinase	unknown	unknown	gnl\|CDD\|234579
NC_014371.1\|WP_004359358.1\|1020677_1021061_-\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_013265781.1\|990935_992636_-\|putative-transporter	unknown	unknown	gnl\|CDD\|179654
NC_014371.1\|WP_013265351.1\|1015470_1016286_+\|TatD-family-hydrolase	unknown	unknown	gnl\|CDD\|223162
NC_014371.1\|WP_013265344.1\|993209_996920_-\|T9SS-type-A-sorting-domain-containing-protein	unknown	unknown	gnl\|CDD\|275380
NC_014371.1\|WP_044046111.1\|1003433_1004351_-\|YitT-family-protein	unknown	unknown	gnl\|CDD\|224203
NC_014371.1\|WP_013265272.1\|999408_1001010_-\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_013265112.1\|1013379_1014177_+\|energy-transducer-TonB	unknown	unknown	gnl\|CDD\|367555
NC_014371.1\|WP_013265855.1\|986621_989930_-\|SusC/RagA-family-TonB-linked-outer-membrane-protein	unknown	unknown	gnl\|CDD\|274948
NC_014371.1\|WP_004359367.1\|1014242_1015217_+\|polyprenyl-synthetase-family-protein	unknown	unknown	gnl\|CDD\|376322
NC_014371.1\|WP_013265255.1\|1018893_1020279_+\|zinc-ribbon-domain-containing-protein	unknown	unknown	gnl\|CDD\|372305
NC_014371.1\|WP_013265700.1\|1012293_1013238_-\|type-IX-secretion-system-protein-PorQ	unknown	unknown	unknown
NC_014371.1\|WP_013265524.1\|1007735_1008167_-\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|225168
NC_014371.1\|WP_013265068.1\|997036_999412_-\|S8-family-peptidase	unknown	unknown	gnl\|CDD\|173804
NC_014371.1\|WP_013265336.1\|1004493_1005918_+\|alanine:cation-symporter-family-protein	unknown	unknown	gnl\|CDD\|376500
NC_014371.1\|WP_013265816.1\|1009405_1011886_+\|ferrous-iron-transport-protein-B	unknown	unknown	gnl\|CDD\|223447

Protein	Function_ID	Function_description	E-value
NC_014371.1\|WP_013265446.1\|1002328_1003411_-\|tRNA-2-thiouridine(34)-synthase-MnmA	gnl\|CDD\|234664	PRK00143, mnmA, tRNA-specific 2-thiouridylase MnmA; Reviewed.	7.58984e-147
NC_014371.1\|WP_044046112.1\|1018121_1018829_+\|glycosyl-hydrolase-family-25	gnl\|CDD\|119375	cd06413, GH25_muramidase_1, Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues.	3.72307e-53
NC_014371.1\|WP_013265765.1\|984753_986466_-\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	gnl\|CDD\|373012	pfam14322, SusD-like_3, Starch-binding associating with outer membrane. SusD is a secreted polysaccharide-binding protein with an N-terminal lipid moiety that allows it to associate with the outer membrane. SusD probably mediates xyloglucan-binding prior to xyloglucan transport in the periplasm for degradation. This domain is found N-terminal to pfam07980.	2.87202e-28
NC_014371.1\|WP_013265255.1\|1018893_1020279_+\|zinc-ribbon-domain-containing-protein	gnl\|CDD\|372305	pfam12773, DZR, Double zinc ribbon. This family consists of a pair of zinc ribbon domains.	2.91065e-07
NC_014371.1\|WP_013265781.1\|990935_992636_-\|putative-transporter	gnl\|CDD\|179654	PRK03818, PRK03818, putative transporter; Validated.	0
NC_014371.1\|WP_013265351.1\|1015470_1016286_+\|TatD-family-hydrolase	gnl\|CDD\|223162	COG0084, TatD, Mg-dependent DNase [DNA replication, recombination, and repair].	2.82176e-84
NC_014371.1\|WP_013265344.1\|993209_996920_-\|T9SS-type-A-sorting-domain-containing-protein	gnl\|CDD\|275380	sd00033, LRR_RI, leucine-rich repeats, ribonuclease inhibitor (RI)-like subfamily. A leucine-rich repeat (LRR) is a structural protein motif of 20-30 amino acids that is unusually rich in the hydrophobic amino acid leucine. The conserved eleven-residue sequence motif (LxxLxLxxN/CxL) within the LRRs corresponds to the beta-strand and adjacent loop regions, whereas the remaining parts of the repeats are variable. LRRs fold together to form a solenoid protein domain, termed leucine-rich repeat domain. Leucine-rich repeats are usually involved in protein-protein interactions.	6.12428e-13
NC_014371.1\|WP_044046111.1\|1003433_1004351_-\|YitT-family-protein	gnl\|CDD\|224203	COG1284, COG1284, Uncharacterized conserved protein [Function unknown].	5.96702e-58
NC_014371.1\|WP_013265112.1\|1013379_1014177_+\|energy-transducer-TonB	gnl\|CDD\|367555	pfam03544, TonB_C, Gram-negative bacterial TonB protein C-terminal. The TonB_C domain is the well-characterized C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance.	1.92728e-13
NC_014371.1\|WP_013265855.1\|986621_989930_-\|SusC/RagA-family-TonB-linked-outer-membrane-protein	gnl\|CDD\|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
NC_014371.1\|WP_004359367.1\|1014242_1015217_+\|polyprenyl-synthetase-family-protein	gnl\|CDD\|376322	pfam00348, polyprenyl_synt, Polyprenyl synthetase.	5.92169e-94
NC_014371.1\|WP_013265273.1\|1016432_1017125_+\|(d)CMP-kinase	gnl\|CDD\|234579	PRK00023, cmk, (d)CMP kinase.	6.99332e-120
NC_014371.1\|WP_013265524.1\|1007735_1008167_-\|DoxX-family-protein	gnl\|CDD\|225168	COG2259, COG2259, Predicted membrane protein [Function unknown].	1.48841e-13
NC_014371.1\|WP_013265068.1\|997036_999412_-\|S8-family-peptidase	gnl\|CDD\|173804	cd07478, Peptidases_S8_CspA-like, Peptidase S8 family domain in CspA-like proteins. GSP (germination-specific protease) converts the spore peptidoglycan hydrolase (SleC) precursor to an active enzyme during germination of Clostridium perfringens S40 spores. Analysis of an enzyme fraction of GSP showed that it was composed of a gene cluster containing the processed forms of products of cspA, cspB, and cspC which are positioned in a tandem array just upstream of the 5' end of sleC. The amino acid sequences deduced from the nucleotide sequences of the csp genes showed significant similarity and showed a high degree of homology with those of the catalytic domain and the oxyanion binding region of subtilisin-like serine proteases. Members of the peptidases S8 and S35 clan include endopeptidases, exopeptidases and also a tripeptidyl-peptidase. The S8 family has an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The S53 family contains a catalytic triad Glu/Asp/Ser. The stability of these enzymes may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	1.487e-22
NC_014371.1\|WP_013265336.1\|1004493_1005918_+\|alanine:cation-symporter-family-protein	gnl\|CDD\|376500	pfam01235, Na_Ala_symp, Sodium:alanine symporter family.	0
NC_014371.1\|WP_013265816.1\|1009405_1011886_+\|ferrous-iron-transport-protein-B	gnl\|CDD\|223447	COG0370, FeoB, Fe2+ transport system protein B [Inorganic ion transport and metabolism].	0

>NC_014371.1|WP_013265524.1|1007735_1008167_-|DoxX-family-protein
MKCLELLFPKAESTKTSLILLASRLVFGLTFASHGLDKLQHFSETAAHFPAPFGLSGEVAVGLSIFGELVCGLAFVFGFLTRLALLPMIFTMLVAFTTVHGGSVSNGELAFLYLVIFVLSWFAGAGKFSVDGIIRSKISGGNS
>NC_014371.1|WP_013265336.1|1004493_1005918_+|alanine:cation-symporter-family-protein
MIELFSADGWLNQAIVSVNYFTWTYILVAGLVICALWFTWRTRFVQFRMIGEMVRLLGDSTGTHDEGEKHVSSFQAFAVSIASRVGTGNLAGVATAIAIGGPGAVFWMWVIALLGSATAFIESTLAQLYKRRHADSFIGGPAYYILHGMHCKWMAKLFAVLITMTFCMAYISIQSNTICGAMQKAFSIDPTWMGGALAILSLAIVFGGIQRIAKVSSVLVPLMAVSYVLLALVIIVMNIQLIPHVFRLIVENAFGFEQVAGGGLGATMMNGIKRGLFSNEAGEGSAPNIAATASTTHPVKQGLIQSLGVFTDTLLVCSCTAFIIIISGLYVNNSESGILLTQVALESEVGAAGPIFIAIAIFFFAFSSIIGNYYYGEANVRFLTQKPSAILALRVITGGVMVMFGAIASLDLVWSIGDFFMALITICNLIAILTLGKYAFRLLDDYRQQKRAGVKSPVFKRETMPDIAKDIECW
>NC_014371.1|WP_044046111.1|1003433_1004351_-|YitT-family-protein
MVRKRKNKFRDVREFLMIALAMLIGSFGWCAFLLPHHITIGGIAGIASVIQWGLDIPVQYTYLTINGILLFVALKILGWKFCVRTIFAVLVFAFSTSVLREVFAGHPLFSDEPFLACVVGGVLLGVGVSIALQYNASSGGSDVIAAMIHKYRDVSLGRVILACDLCIISSSYLVLENWEKVIYGYIVLFVMTYVVDYLINGMRGSVQFFVISEHWGEIGSAINNDVDRGCTVIEARGFYTGKKVGMLFVIARRSEAHSIYQVIDEIDPNAFVSQGAVNGVYGMGFDRMKVAHKKKTADEKVRTKE
>NC_014371.1|WP_013265446.1|1002328_1003411_-|tRNA-2-thiouridine(34)-synthase-MnmA
MNIQELEGKRIAVLLSGGVDSSVVVYEFARLGLHPDCFYIKIGPEEKEDWDCNSEEDLEMATLVTRRFGCKLEVIDCHKEYWDQVTRYTMEKVKAGFTPNPDVMCNRLIKFGAFDEKMGHDYDLIATGHYAQTEWIDGRKWLTTSPDPVKDQTDFLAQIYDWQLKKAIFPIGHYEKNEVREIAERENLINAHRKDSQGICFLGNIDYNEYVRRYLGEEIGDVIELETGKKIGEHKGLWFHTIGQRKGLGLGGGPWFVIKKDVTKNILYVSHGYDPATAYKKDFPLHDFHFLTEGITTLPEKITFKIRHTPEYHPATVEQLSDGRCIIHSTENIHGVAPGQFCVVYDEQHHRCFGSGEITL
>NC_014371.1|WP_013265272.1|999408_1001010_-|hypothetical-protein
MKQVYYFIFLMLLAFSSVNVKADTTVRVKVDDINRVSVKVNYLPVVNLANGTNEITVPQYGALTIEAKQGYYLKSVLKTIDNDNSAPQTINNLTSCNIYVSDADNNKLFTVKSADLAKARTGSCTVNVDNASKVRVSRNESRTSVELQNGENTVKWIPNTEKTLVITNANYGDAPIYKVTLDGNDVTPSSGQYFVTLTAGCVVDIKADYPNVSYPVKFNFTDEKAKGVISKVMADGEEVKNYNDADFKLKAGTKLSLTFDQRNYALDAFKVNGTATTIYGTYECYVKDNLVFDIQAHKYATVKAVLTVDKAANITAYEGQSYNNKVITLQNGSNNIELGEKNNLIQIKPNSGCKIESIKANGTPVTANYEGAYEIRLTDGMTIEVTTSAIVRDQKATVFIDDISLANYGFNFYRSDHSTIKMQTGENTVMFSADDHHFMLGAYGNDLSKMVVKLNGTILAPSYPGGTSFEFDLKNNDRLDVLLKGDTAGIDAIEAVKQGKAVVYRLDGKRIEGTQLPNGVYIINGKKVIVNKR
>NC_014371.1|WP_013265068.1|997036_999412_-|S8-family-peptidase
MRKILLTVFCLCSVGLAYGQSKLDLQSQLELFKLRNTSIPTYNSRTRSFERPKSVPENTMAMVEMKDQNDRADLEAQGVKVLRVRGNIAIVVAPIKDIERIAGLKCVRRMELPRRVYQKMDVVRKEIGVDKIHKGIDLPQAYTGKGVVTGIVDGGIDPNHINFLKPDGSTRFGYISKITASQSNKDGYQFDNYYPRVVLDTLTNRDNAYAIEDFTTDSYTTFHGTHTTGIMAGGYKGNINYAKTNDNDRSYKVTGPNPFYGCATESELVASCGDLRDQYIAFGVDDVVQYAKLSGKKPKPCVINLSLGSNIGVHDSTSVMNRFLAEEGKHAIICVAAGNEANMGIALKKNFTAADETVKTFLTPMQPDTLRSGGKTYFNLRNGQIAAYSNDSTEFELQIVVTNTKRGNRVVSRIPLPNNTNGQPITYASGGEYSMSGAVINQGFAKAFDGYVTAASAIDPETGRYYAMAQIMTSDNQKDNKDGNYKLALLITSKKPGQRVEVYSDAQFIYFDSNKQEGFVSGTRNGSISDMACAANIVTVGSYNVRNHWSSLDGFVYGYNKRGDEDDFPEGEASRFSSFGTLADGRNLPHVCAPGASIISSVNTYAVENTDLGYTDMALQGKLEKGGKKYYWHQSLGTSMATPVVAGAIALWLEANPSLTVKDVIRIIQQTARKDDYVTKTGDPVQWGAGKFDAYAGLKQVLKEKETNGINGVRYAESQAVPVITMTGERSFSAFLAGAKQLNLRAYSLSGQLVHSLSAQGDELNVNASSWNKGVYLIQVNGGKAQRIVIY
>NC_014371.1|WP_013265344.1|993209_996920_-|T9SS-type-A-sorting-domain-containing-protein
MKHKFTFLPSFLLLVMAMLWSSLAAHAQDEVLIRFHTNVPEKAKNSGVAAQVSFVLGSKSDKADVSIDYGSGDTEVEINKAIVENDHGEQAIKGTLCTDVVSDAGWVTIKGNPDDLYFFNASGNEIDQIQFNDNLKLQVLNLEHNNLKSLNIDRLQSLNIIYLQDNPFSATTPLMIGRMPNLMVLEVPQIGHISPDFTLKNFPNLRSFDAYHTISLKTADPTGCPYLQRLSLDMTSVESVDLSKNSLLQILNVGDSRVKTLDLSHNPEITQLYISHSSGAVNTDVKFETIDVSHCPKLYYFYCGGNNLKELDLRNNPELFTLSCDRNLLRNLDVSQNPKLYSVNVRYNYMDFATLPEPGNWFEYYHEQNPMELNDTYKVGDVIDLSKRVLRANTTTQARLYRVPKDDPTKPVELDDSYYSYEGGKVTLKKELNEEVFVQFTNSRLRDYPIRTENFRVKTVAEFGKDVKAIQLASLGDAGSPLKMSVGILGATAANPVTVKVDLGDGNTTPFEIKDERPATANIVTTRTGAGDIIVYVPQDKYVTSLESDGQYIDNIDLSALTELRTLTLKRANLTTIDLSYNNKLEKLDLSYNQLNRVDLRGPSSYFNKSKLTDINISHNQVDSLLFNTIYGVTKLNVSHNKLNKLDLKDADNLRMLDISYNKFTRLLLNHSELIEDINVANNELTEVKIPPVAPVKKLNVSGNYFTLANMPNDFGLTRGNFIYAPQNVLQISTSSPGIDLSEQYITKDGATTNFVWKKKDGTPLQLGKDYTITNGSAKFTNLALDSIYCEMTHAAYPDFEGKNVFKTTNVHPIAFPKYELASFTTVNQTDSVVLSLASYVPGKSVYFEWGGNGNVTQYTLGEKYKIFQAKSKANTKVRVLVAEADDKVKVFSVANVKMTDVDLTGLKEAKLISITQAGLTSVKLPAAPNLTDLNFDGNELTDIDLSPFPKLFAVSLIGNKIKNFDLSKAPNLGIAYLSSNKMKEIKLDNPKLESLDLSDNDLENVSLDKLPQLEQLWLNANKLTKVDVSKNTNLRVLNVVGNRLKFSTMPLPNNNGKRFDRYSYNLQAPIDVKCVNGKVDLSSEAVVGGEMTTYHWFIGNVTYRDGELQGEKLEVNDEYTVENGVTTLKLTQSITNLVCVMSNDNFPNALIYTNYIAFTPATGIDAVTADKDVKIQFFDGAISVLGAQNSTVAIYSIDGKLVYQGKVADDSTRISLARGTYIVRVGNKAAKISVK
>NC_014371.1|WP_013265781.1|990935_992636_-|putative-transporter
MDWLIDIFSAEKQDTVAHIMLLYSIVIALGIYLGKIKIGGISLGVTFVLFVGILAGHIKFTGPIPVLTFVQDFGLILFVFMIGLQVGPGFFESFGKGGLKLNILSTVAILLNVLVMFACYYIFFDTQDKTNLPMMVGTLYGAVTNTPGLGAANEALHSVFKNGMNFDIASGYACAYPLGVVGIISATIAIRYICKVNLQEENEKLNEEEAENPHAKPYTMYLKVQNAYIAGRKLEEISEFLNRDFVCTRLMHEGVLSVPTLDNIFELGDEILVVSAEADAAAIRAFIGPEIEVDWHEEDQPQQLVSRRIVITNSKINGKTLGDIHFRSVYGVNVTRISRQGMDLFAGRNHRFIVGDRIMVVGPEENVNRVASMMGNSEKRLNAPNIATIFVGIIVGIIFGTLPIAIPHMPVPMKLGLAGGPLVIAILIGRFGYRMGLVTYTTTSANMMLREIGLALFLASVGIKAGATFWDTVVQGDGLKYVYTGFIITIVPILIVGTIARLKYKFNYFTIMGMLAGTYTDPPALAYANSICAGEAPAVGYSTVYPLSMFLRIFLAQVIVLFFCQI
>NC_014371.1|WP_013265855.1|986621_989930_-|SusC/RagA-family-TonB-linked-outer-membrane-protein
MEKRITLFLFGLILSLGTAFGQAKINGTVVSQDDGEAVIGASVMVQGTTTGTVTDIDGHFTIDVPAGKKLVVSYIGMVTQTVTAKDGMKVVLSNDNHQLTEVVVTGMTQQDKRLFSGAATKIDASKAKLDGMADVSRSLEGRAAGVSVQNVSGTFGTAPKIRVRGNTSIFGSSKPLWVVDGVIMEDIANVDASSLSSGDAKTLISSAIAGLNADDIESFQILKDGSATSIYGARAMAGVIVVTTKKGKAGQSHLSYTGEYTLRLKPSYKNFNIMNSQDQMEVYRELEKKGYLNYAEIANASTSGVYGRMYQLISEYDATKGQFGLENTQKARDAYLRAAEYRNTDWFDQLFSSSIMHNHSVSASGGTDKGQYYASLSAMYDPGWYKSSRVQRYTGNINTTYNINKKVGLNLIANASYRKQRAPGSLSRTIDPSTGAVSRAFDINPYSYSLNTSRTLDPTESYTRNYAPFNIFNELNNNYMDLNVHDFRIQTSIDYKPITKLKLTALVAVKSAASTMEHVVRENSNQALAYRAMGTTTIRDANPYLYTDPDNPFALPESILKEGGILDRTGNHFFGWDTRLSAAYNDVFNDTHIVNLYAGVESNSVDRKATFDREWGMMFDAGEIAKLNYRAFKMFQEKGSDYYGLSNTHIRSLAYFGTGTYSYKGRYQMTGTFRYEGTNYLGKATSARWLPTYNVSGAWNAHEEEWFNKVFKQALTHATFRLSYSLTGDRPPVTNSLPIFTATVPWRPFTSIQETGYDEQFGNKNLTYEKKREFNLGFDFGFLDNRINLTTDFYWRRNSDLIGYVNHPQLGSYNLANVASMKSNGMELSLNTHNIKTKDFSWESNFIFSWTHNEITSLFTHARVIDLVQGTGYSLVGYPVNSIFSIPFAGLDGEGLPTFMNEDGRRTISGLNLQERDQEKIKYLKFEGPADPTTTGSFGNVFRYKNWDLNVFVTYSFGNKVRLNHIFSNRYDDMDALPKEFRNRWTYSGDETLTTIPVIASRRQNRNNSQLDVAYNAYNYSDVRIAKGDFIRMKEISLGYTFPAAMIRTIGVSSLALKLQATNLFLFYSDKKLNGQDPEFFNTGGVAAPVPKQFTMTLRLGL
>NC_014371.1|WP_013265765.1|984753_986466_-|RagB/SusD-family-nutrient-uptake-outer-membrane-protein
MKIKNIIYKGSLMLASVAILASCSDQLDTLPDNRTTLDTPKKIAGLLVTAYPDRTPTLFNEWMSDNTDYMGAQNSQGNRGGDQYFFWQEQTEGGNDSPEQVWMLYYEGVYKANEALAAIEDQGGPKNDILRNSKGEALLIRAYDHFILANEFCRPYNGKTSTKDAGLYYATGIADFSAAAEQSNRGTVADVYAKIAADIEAGIPLLNDTYEVPKYHFNKQAAYAFATRFYLYYEKWEKAKEYADKLLGSNPAASLRDYRALQAMPLSKSEQAVKIAEAYCSASADCNLLVQTSVSNAGMALAPWLTSKRYTLTNYLAETELFQSNNIWGTSSNLIWKPFTVNSGESNFALLMKLPREFEIRNTTTGSGYLRTLNVDFTMDEALLNRAEAEIMLGQNDAACADMTIWMKNFFNTNVTLTPTSVQTYFKTVPYAYADAAKMVPSFKKHINPRFTIGAEGSVQESLLQCLLNFRRIETVHQGMRWMDIRRYNIEIPRRLIGANGRPSKNLDWLEKDDPRQVVQIPQSIREAGVAGNPTKALVAGAKLVDLSQYKLPVLSAVNQYSAPVSAHSF
>NC_014371.1|WP_013265816.1|1009405_1011886_+|ferrous-iron-transport-protein-B
MKLSELKTGETGVIVKVSGHGGFRKRIIEMGFIKGKTVEVLLNAPLQDPVKYKVMGYEVSLRHSEADQIEVLSDVKTHSVGNEEEQEDNQVEMDSTTDDSTDKELTPEKQSDAVRRKSHTINVALVGNPNCGKTSLFNFASGAHERVGNYSGVTVDAKVGRAEFDGYVFNLVDLPGTYSLSAYSPEELYVRKQLVDKTPDVVINVIDSSNLERNLYLTTQLIDMHIRMVCALNMFDETEQRGDHIDAQKLSELFGVPMIPTVFTNGRGVKELFRQIIAVYEGKEDESLQFRHIHINHGHEIENGIKEMQEHLKKYPELCHRYSTRYLAIKLLEHDKDVEQLVSPLGDSIEIFNHRDTAAARVKEETGNDSETAIMDAKYGFINGALKEANFSTGDKKDTYQTTHVIDHVLTNKYFGFPIFFLVLLVMFTATFVIGQYPMDWIEAGVGWLGEFISTNMPAGPVKDMIVEGVIGGVGAVIVFLPQILILYFFISYMEDCGYMSRAAFIMDRLMHKIGLHGKSFIPLIMGFGCNVPAVMATRTIESRRSRLITMLILPLMSCSARLPIYVMITGSFFALKYRSLAMLSLYIIGVLMAVAMSRLFSAFVVKGEDTPFVMELPPYRFPTWKAIGRHTWEKGKQYLKKMGGIILVASIIVWALGYFPLPDDPNMDNQARQEQSYIGRIGKAVEPVFRPQGFNWKLDVGLLSGMGAKEIVASTMGVLYSNDGSFSDDNGYSSETGKYSKLHNLITKDVATMHHISYEEAEPIATLTAFSFLLFVLLYFPCVATIAAIKGETGSWGWALFAAGYTTALAWIVSAVVFQVGMLFM
>NC_014371.1|WP_013265700.1|1012293_1013238_-|type-IX-secretion-system-protein-PorQ
MKKIVFTLLLALFAVVIRAQESQTEYNFLRLPVSAHAAALGGENITIIEDDPSLMFSNPALASSVSDKTVGLSYMNYMRGAHYMGASYTKALGEKATLAGGVQYMNYGKMKEVDANNVQTGTFNASEIAVEGIFSYELARNLVGGITAKFITSYIGSYNSMAVGVDLGLNWYEPERQWSVSLVAKNLGGQIKAYEEEYGKMPIDVQVGVSKTFAALPVRVSATLVDLTHYDYRFINHLNLGAEVLLSESIWVGGGYNFRKADEMTIGKADNASAHGAGFSVGAGINLEQFKLNLAYGKYHAASNSILVNLAYSF
>NC_014371.1|WP_013265112.1|1013379_1014177_+|energy-transducer-TonB
MEIKKSNRADLENKRWVGFLLGIIVALSFFFVAMEYNATGSDDDSANTKAIKNVTLHDMDMLPAIDQQDLAKTQEDKKPTMEDLLNLKRRDIPNKVTPHDAGSMNSNDKKTGAPQVSNEPIVMPMVTTTTEPPKIKEEAKKEMEKMTDDNSDKVVERYDDKVSKRILSETPTPPGGWVEFMKWLTKTLQYPAAAKENKLQGTVNITFIINADGTVDDVRIKSGKVPVLNDEVLRVLKTMGKWKPGIEKNKPCRSLIEIPFVFQLA
>NC_014371.1|WP_004359367.1|1014242_1015217_+|polyprenyl-synthetase-family-protein
MYTANEILSKVNEYINNLTYDRKPQSLYEPIKYVLSLGGKRIRPTLMLLSYNLFKDDPETILSPACALETYHNYTLLHDDLMDDAPLRRGQQTVHVRWDANTAILSGDSMLVLAFERMAQCDSRHLSEVLRLFTVTALEIGEGQQYDMEFENRNDVKEEEYIEMIRLKTSVLLACAMKIGAILADAPAEDVENLYKFGEQIGLAFQLQDDYLDVYGDPKVFGKKIGGDIICNKKTYMLINAFNKANARQCKELEKWIGCENFNHEEKVAAVTELYNSIGVDKMAIERINYYFDEANKYIAAVNLPDERKAELLAYAQKMLHRKW
>NC_014371.1|WP_013265351.1|1015470_1016286_+|TatD-family-hydrolase
MIIDTHAHLDVEDFADDLPEVISHAHEAGVGKIFLPAIDLKSVDTVLAVCRQFPDTCYPMIGLQPEEVRDDWREVLDAMHERILLSLRQKAEGTAKPGETVIAIGEVGLDFYWTREYEKQQLAAFEEAVKWSVETRLPLMIHCRKAQNEMLHIMRPYEKELPGGVFHCFTGNQKEAEEFLRFDRFVLGVGGVSTFKSSHLREDLPAAVPLDRIVLETDSPYMAPVPHRGKRNESAFIVEVMRTLALSYGVDEAEFARQTNENVRRVFGVGC
>NC_014371.1|WP_013265273.1|1016432_1017125_+|(d)CMP-kinase
MKKITIAIDGFSSCGKSTMAKDLAKEIGYIYVDTGAMYRSVTLYALRHNLFNTDGTIREEELQAQMKDINISFQLNKETGRPDTYLNGENVENEIRTMEVSSHVSPIATLAFVRKALVEQQQRMGAEKGIVMDGRDIGTVVFPNAELKIFVTASAEVRAQRRYDELKAKGMEADFADILKNVQERDYIDSHRETSPLRKADDALELDNSQLTIAEQKQWLYNQYLKAAEA
>NC_014371.1|WP_044046112.1|1018121_1018829_+|glycosyl-hydrolase-family-25
MKLKKIIMLIACIFSFAGLKAQYTIQCEDTCSHVHGLDMSHYQGDVWWETVAENSNHKLNYVYLKATEGGTRIDQRYLENIEAAQRYGMNVGSYHFYRPAIPQEEQLRNFRMQCRPQDQDLIPMVDIETTGGLSTEALRDSLQRFLVLMTQEYGVKPLVYTYTNFYNRYLSGALDGYKLFIAQYNGREPELNDGRDIFAWQYTGKGRINGVRGYVDKSRLMGNHSMRELRFRRKR
>NC_014371.1|WP_013265255.1|1018893_1020279_+|zinc-ribbon-domain-containing-protein
MIIKCPECGHQVSDKAPVCPSCGVEIAGHIIKCSHCGELYLKEESSCPNCHHTEHHVESSVTAAEHHTSEATNDSKVQEPVVLMSVDKGEVTGNDDVIIPVEETEEHETDNYDNKTQDTINEPNTEEEAVDADFIMDDNADEEVIANAEAIAEDEEESTPDKNNHLSLAVSLLIAAITAAVLLFLYNQGVGASKANNEQEAFAQAMSSSEPTVLKNYLKENPSASKAHRDSISARLKVLTTTTQNMQQSDNDLSVALTSNSKEVLQQFIAKYPDSKHRGELEAKIDEIDWAGAVAKNNENAYLGYKAQHPNGIHSKEADEKLKNILTPEMAEESAAAKVTDGERAKAVAAVRQLLQGINSKSTDKISGAVAPSLNFLGSGGATVKDIRRYMTDRLYQADVKTINWHLGSPTEVTKNSNEAGADIRLKIPATLDIDRKGGKSKRSYVISATIKNGRITHINW
>NC_014371.1|WP_004359358.1|1020677_1021061_-|hypothetical-protein
MKKKPTYKVPVSICAIVLVVGAIVLAVLMETREMAPPRKYEVDMSGEVIGIDNGPKIPVLTKEEEKDEEVKEEKKTEAPKKESSESEETADPENPVIVPNVPEGQTEPVVKAPVPEIKKPTIDQIEN
>NC_014371.1|WP_013265208.1|1021102_1021585_-|hypothetical-protein
MKKILLLLTVLLFAMGARAQKDIVSMADAIKIFQAKTLQVGKQVLEKQGYSYKGVSSDEFGKDYNWVKNMNLTSDFLPTAMGRGNSSMVLLAQNGKTVYVYVFNRTAFAGLQAQVKAMGYDMGNAVKGDKTTLICTKDNQPTISFLTLQQPLPYCVQITE

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Crispr_ID: NC_014371_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014371_5

1136615-1136751

Orphan

Consensus_repeat	Method
CGGTGTTGTCTTAACTCCTTTAACTCCATTTAATTCCTTAACTCCACATC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014371_5

>merge|NC_014371|5|1136615-1136751|CRISPRCasFinder
CGGTGTTGTCTTAACTCCTTTAACTCCATTTAATTCCTTAACTCCACATCCTTTCCTCCTTAACTCCACATCAATCCTATGAGTCAGCGGTGTTGTCTTAACTCCTTTAACTCCATTTAACTCCTTAACTCCACATC

>NC_014371|5|5|1136615-1136751|CRISPRCasFinder
CGGTGTTGTCTTAACTCCTTTAACTCCATTTAATTCCTTAACTCCACATC	CTTTCCTCCTTAACTCCACATCAATCCTATGAGTCAG
CGGTGTTGTCTTAACTCCTTTAACTCCATTTAACTCCTTAACTCCACATC

Protein	Signature genes	Signature genes Name	Protein_function
NC_014371.1\|WP_013265232.1\|1123368_1123980_-\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_013265534.1\|1147414_1149115_-\|family-10-glycosylhydrolase	unknown	unknown	gnl\|CDD\|224563
NC_014371.1\|WP_013265712.1\|1142244_1145736_-\|glycoside-hydrolase-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|379625
NC_014371.1\|WP_013265396.1\|1151721_1152153_+\|transcriptional-repressor	unknown	unknown	gnl\|CDD\|223806
NC_014371.1\|WP_052299148.1\|1130393_1130618_+\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_174254489.1\|1133224_1133473_+\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_013265699.1\|1127710_1129327_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|237894
NC_014371.1\|WP_013265677.1\|1146597_1146996_+\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_013265883.1\|1125891_1127055_-\|molecular-chaperone-DnaJ	unknown	unknown	gnl\|CDD\|237660
NC_014371.1\|WP_013265809.1\|1130671_1132216_+\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_088582090.1\|1136771_1137995_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340952
NC_014371.1\|WP_013265787.1\|1127069_1127648_-\|nucleotide-exchange-factor-GrpE	unknown	unknown	gnl\|CDD\|271355
NC_014371.1\|WP_013265399.1\|1150057_1150489_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|223979
NC_014371.1\|WP_013265178.1\|1124356_1125649_-\|bifunctional-folylpolyglutamate-synthase/dihydrofolate-synthase	unknown	unknown	gnl\|CDD\|273659
NC_014371.1\|WP_044046127.1\|1150897_1151710_+\|GSCFA-domain-containing-protein	unknown	unknown	gnl\|CDD\|378080
NC_014371.1\|WP_108235565.1\|1138343_1141823_-\|DUF4981-domain-containing-protein	unknown	unknown	gnl\|CDD\|236673
NC_014371.1\|WP_013265512.1\|1122332_1123388_-\|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein	unknown	unknown	gnl\|CDD\|378065
NC_014371.1\|WP_013265819.1\|1152236_1154717_+\|bifunctional-UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine-ligase/alanine-racemase	unknown	unknown	gnl\|CDD\|237026
NC_014371.1\|WP_013265130.1\|1133510_1135292_+\|fimbrillin-family-protein	unknown	unknown	gnl\|CDD\|372499
NC_014371.1\|WP_036924016.1\|1150505_1150718_-\|DUF3791-domain-containing-protein	unknown	unknown	gnl\|CDD\|372250

Protein	Function_ID	Function_description	E-value
NC_014371.1\|WP_013265534.1\|1147414_1149115_-\|family-10-glycosylhydrolase	gnl\|CDD\|224563	COG1649, COG1649, Uncharacterized protein conserved in bacteria [Function unknown].	7.33227e-47
NC_014371.1\|WP_013265712.1\|1142244_1145736_-\|glycoside-hydrolase-N-terminal-domain-containing-protein	gnl\|CDD\|379625	pfam14498, Glyco_hyd_65N_2, Glycosyl hydrolase family 65, N-terminal domain. This domain represents a domain found to the N-terminus of the glycosyl hydrolase 65 family catalytic domain.	1.1523e-49
NC_014371.1\|WP_013265396.1\|1151721_1152153_+\|transcriptional-repressor	gnl\|CDD\|223806	COG0735, Fur, Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism].	6.75173e-21
NC_014371.1\|WP_044046127.1\|1150897_1151710_+\|GSCFA-domain-containing-protein	gnl\|CDD\|378080	pfam08885, GSCFA, GSCFA family. This family of proteins are functionally uncharacterized. They have been named GSCFA after a highly conserved N-terminal motif in the alignment. Distant similarity to the pfam00657 lipases suggests these proteins are likely to be enzymes.	3.01699e-90
NC_014371.1\|WP_013265699.1\|1127710_1129327_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|237894	PRK15064, PRK15064, ABC transporter ATP-binding protein; Provisional.	0
NC_014371.1\|WP_013265883.1\|1125891_1127055_-\|molecular-chaperone-DnaJ	gnl\|CDD\|237660	PRK14289, PRK14289, molecular chaperone DnaJ.	0
NC_014371.1\|WP_013265819.1\|1152236_1154717_+\|bifunctional-UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine-ligase/alanine-racemase	gnl\|CDD\|237026	PRK11930, PRK11930, putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional.	0
NC_014371.1\|WP_088582090.1\|1136771_1137995_-\|MFS-transporter	gnl\|CDD\|340952	cd17394, MFS_FucP_like, Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters. This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.69592e-67
NC_014371.1\|WP_013265787.1\|1127069_1127648_-\|nucleotide-exchange-factor-GrpE	gnl\|CDD\|271355	cd00446, GrpE, nucleotide exchange factor GrpE. GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.	5.18116e-46
NC_014371.1\|WP_013265399.1\|1150057_1150489_-\|NUDIX-hydrolase	gnl\|CDD\|223979	COG1051, COG1051, ADP-ribose pyrophosphatase [Nucleotide transport and metabolism].	1.41016e-36
NC_014371.1\|WP_013265178.1\|1124356_1125649_-\|bifunctional-folylpolyglutamate-synthase/dihydrofolate-synthase	gnl\|CDD\|273659	TIGR01499, Folylpolyglutamate_synthase, folylpolyglutamate synthase/dihydrofolate synthase. This model represents the FolC family of folate pathway proteins. Most examples are bifunctional, active as both folylpolyglutamate synthetase (EC 6.3.2.17) and dihydrofolate synthetase (EC 6.3.2.12). The two activities are similar - ATP + glutamate + dihydropteroate or tetrahydrofolyl-[Glu](n) = ADP + orthophosphate + dihydrofolate or tetrahydrofolyl-[Glu](n+1). A mutation study of the FolC gene of E. coli suggests that both activities belong to the same active site. Because some examples are monofunctional (and these cannot be separated phylogenetically), the model is treated as subfamily, not equivalog. [Biosynthesis of cofactors, prosthetic groups, and carriers, Folic acid].	3.32714e-121
NC_014371.1\|WP_108235565.1\|1138343_1141823_-\|DUF4981-domain-containing-protein	gnl\|CDD\|236673	PRK10340, ebgA, cryptic beta-D-galactosidase subunit alpha; Reviewed.	0
NC_014371.1\|WP_013265512.1\|1122332_1123388_-\|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein	gnl\|CDD\|378065	pfam08843, AbiEii, Nucleotidyl transferase AbiEii toxin, Type IV TA system. This family was recently identified as belonging to the nucleotidyltransferase superfamily. AbiEii is the cognate toxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.	3.5386e-20
NC_014371.1\|WP_013265130.1\|1133510_1135292_+\|fimbrillin-family-protein	gnl\|CDD\|372499	pfam13149, Mfa_like_1, Fimbrillin-like. A family of putative fimbrillin proteins found by clustering human gut metagenomic sequences. Analysis of structural comparisons shows this family to be part of the FimbA (CL0450) superfamily of adhesin components or fimbrillins.	2.79247e-09
NC_014371.1\|WP_036924016.1\|1150505_1150718_-\|DUF3791-domain-containing-protein	gnl\|CDD\|372250	pfam12668, DUF3791, Protein of unknown function (DUF3791). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 71 and 125 amino acids in length.	3.15295e-18

>NC_014371.1|WP_013265130.1|1133510_1135292_+|fimbrillin-family-protein
MITKSLYSILLSVAFLGLASCSSENNDEHSELVGTSTRSFVVKQETAPLTRTNVSLTNGITWNAGDRLFAYNVTKPQGYDQLTAISDGERSDLKGDIHWKEGDELALFYPFRHVYRENMGKVDLGLSENTLYHKGELVVRRQNGTVENFRYFDYAWGKLKNIKEAGKDIWADFKLERQYSVLCLKVLYEGQPVTDMKQLTIKNVYNEATFDLAIGKMTYEQPKGELKITADTPLETFYVALFPDANFTPSYIIETVNGKKFYATVTEPLNYQPAKYYEYTVHVTTTPCPSPSPCIDIDGTKWGKYNLQYEPCTNLEGWVPGYRLAKQAWDYFYTNSDPFNLYPDFLPRAFNTSAFDHFRWGSIAAANNYSYSYSRYYSYHMGNLQAVIQNRCYGDLAYYASNGKFMMPTKADFDNLMAKTGEYVGYYQDGCNIIVGVLFDPTVPACKKGKVLDKNGHIIGNTNRPNGIYVGKYYEHNTRMKKFSKEDIDKGVFFPFAGAYTEYNDGAPRLQRPGGQAYYWTSDANRCNYAQATAFSAYYMNNGWLYPGTVNGSGSGNNPKYNMYNIRPLCVSSDSKTKQNNQTKQSYQTKKGW
>NC_014371.1|WP_174254489.1|1133224_1133473_+|hypothetical-protein
MKNYLKPYTACTKVESEGYLLAGTGSAGNGGFTSGGGNQGGGNQGGENKGGGGCNDCDNTKNHTKSAPSSVTNGFFFSSGGE
>NC_014371.1|WP_013265809.1|1130671_1132216_+|hypothetical-protein
MRKQTFKVRLLSLIALCGIVMVFASCSNEDVAQSTVETNTEKNSNLTSFVTGAAATRTSLNYDNGAFFWEAGDHIYVKDDNGTWQKSRNAPTEKTASFKFMVPGKYTNSTTYKVYYPGKNGLNNNVTISGTQSQAQPNSTTHIGEAGDCGTADATRNGGVFNFRLDHQAAILVFQPFTNNTAVKNCYLTKIEVESDNDITDTYTLDTTTGELTGTGSGKTITMTTKGSGSYANGFSLNTSTADVKTNGAYVVIRPGTHALTVRYWIKDYVTNVEGAITKTYDSFKYEKNDYYDMTADINVTDYDGSKYYMWDAQKNYWNGHEWNSANPWQPVLANKSNPNYPVSGSSYFHRTGGFGREDAMNSSCKNLPNANELGWYVKNGDPRWDDDKLWTAMGHLYKGGIWLRNKAYINLITSFNSDQGPSYLDMRDNYARFEVTPIQGAPVGYFASRYFFLPALGKYSDGYLSKIGERGFYWSSSASPVDETWAYSLEFSKSQVIVSPTSSNDGYYIGTFE
>NC_014371.1|WP_052299148.1|1130393_1130618_+|hypothetical-protein
MKQNKIKIGYQAPYTEVIVINNETLLAENSFPGQHRPGNHKKGPNANNAKQALEWLEVGDEASSSNEHTSLWED
>NC_014371.1|WP_013265699.1|1127710_1129327_-|ATP-binding-cassette-domain-containing-protein
MITLSNLAIQFGKRVLYKDVNLKFTPGNIYGVIGANGAGKSTLLRAISGDLEPNKGTVELGPGERLSVLEQDHFKYDEYKVMDTVLMGHDALWQNMKEREELYAKPEMTEEDGNRAADLELKFAEMNGWEAESNAAQLLQNLGVKEELHEKQMSQLSNTEKVRVMLAKALFGKPENLLLDEPTNDLDLETVEWLEDYLGEIDEHQTVLVVSHDRHFLDSVSTQTIDIDFGKVTVFAGNYSFWYESSQLALRQAQNQKMKAEEKKKQLEEFIRRFSANVAKSKQTTSRKKMLERLNVEEIRPSSRKYPGIIFSMEREPGNQILEVENLKAVDEDGTVLFDNVNFNIEKGQKVVFLSRNSKAMTALFEIINGNREPDAGTYNWGVTITTAYLPLDNTEFFDCDLNLVDWLSQFGPGNEVAMKGFLGRMLFKQEEVEKKVNVLSGGEKMRCMIARMQLQNANCLILDTPTNHLDLESIQAFNNNLIGFKGNILFSSHDHEFINTVADRIIELTPKGTIDKLMSYDDYIHDEQIKEQKAGMY
>NC_014371.1|WP_013265787.1|1127069_1127648_-|nucleotide-exchange-factor-GrpE
MSKKEKNIKIEGEELELNNEETTQNYAEAQAEDANGEETPAEEELDPLVAAQNDAEQWKDKYIRLVAEFENYKKRTLKEKSELILNGSEKTVAAILPILDDFERATADKTEDPQAIKEGYELIYKKFLKALETLGVNKIETDNADFDVDYHEAIAMVPGMGDDKKGKVIDCVQTGYTLNDKVIRHAKVAVGQ
>NC_014371.1|WP_013265883.1|1125891_1127055_-|molecular-chaperone-DnaJ
MAKRDYYEVLGVSKNASEDEIKKAYRKLAIKYHPDRNPDDPEAEAKFKEAAEAYDVLHDPQKRQQYDQFGFDAPGGGFGGGGPFGGGGGFSMDDIFSMFGDVFGGHGGGFGGFGGGGHQAPKYRGSDLRLKVRLSLQEVATGVTKKFKVRKDIPCEHCHGTGAEEGSGTETCQNCHGSGVEIRTQQSIFGMMQTQTTCHVCNGEGTIIKNKCTHCHGEGVVKGEEVVEINIPAGVAEGMVVNVPGKGNAGRHNGVAGNIQVYIEEEPNDTFIRDGQNVIYNLLLDFPTAALGGQVDIPTIDGSNVKIKIEPGTQPGKTLRLRGKGLPAVQGYGSGTGDLVVHISIYVPKELNKEEKKIIEDLRQSENFRGDNSTKRSIFENFKKLFS
>NC_014371.1|WP_013265178.1|1124356_1125649_-|bifunctional-folylpolyglutamate-synthase/dihydrofolate-synthase
MTYQETVEYLFNSTPVFEHVGASAYKEGLETTKALDEHFGHPHTHFLSIHVAGTNGKGSCSHTLAAILQAEGYKVGLYTSPHLVDFRERIRVNGKMISEQEVIDFVEQERNFFEPLHPSFFELTTALAFKHFAEQKVDIAIIEVGLGGRLDCTNIITPILSIITNISLDHTQFLGNTLGAIAAEKAGIIKHRVPVVIGESVPETQIVFKAKAQKEDALIVFAEDIPAILSSRPNPDGGIAYQTRFFGDIVGELGGSYQEKNANTVLTAVMQLYNKGVIKNAESIAKGFANVCELTGLMGRWQKLQANPLVICDTGHNVGGWTYLSQQIKRQQCKQKRIVFGMVDDKDLHAVMSMLPDDAIYYWTQPSTHRAFPAEKVAATADEYDLHGMVFPTVLDAYQAALHDAAQSDFIFVGGSSYVVADLLTSLQKK
>NC_014371.1|WP_013265232.1|1123368_1123980_-|hypothetical-protein
MTIQEQIKQRIDEAEPGTVFFVNDFAEFDNEYVSKLLSTMKGFGVLERLAKGIYYKPIVTNYGNVYPSAEKIVKLIAEHENAEILPTGEYALNALGLSTQVPMKAIYLTTGSPRTITIGNKKIRLKHRTPSTYSYHSKLMPLLVLALKAKGQSNITSADTNRIEKLISDSTEKQQIKTDLATAPVWVRKYIKPIIEKYEHLAR
>NC_014371.1|WP_013265512.1|1122332_1123388_-|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein
MSIWQDKTIEERIAIVQNTALRTNIEDLAIEKDWWVTITLKALFSTSFSEFLLFKGGTSLSKGKWENIDLRRFSEDIDISLSRSWFTETEEKQKLYPFAKCENNNQLKSLRKASREVIFERLSPELNEQLAKLGAKDFYVENVKSIIQDGVEIPIDTDRDPVVLNVVYPSILDETNEYIQPKVKIEISCMSMDEPFENRALTSLIYDTFNEVDNATQCFVPTVLPIRTFLEKALLLNEEYQKKSPRSERMSRHLYDLERLMDTYSETAINDSELYKSIIEHRKKFYHISSVDYDSDKRENIKIWPTGEIENLFRDDYKAMIESFIYNENPLTFDQLRERILLLEDKFRENT
>NC_014371.1|WP_088582090.1|1136771_1137995_-|MFS-transporter
MMKQKTNYLFPLAIIGLFFFSIGFALGINSYLMPVLEKSMHISGAASSLLLAATFIPFLLFGIPATHCIKAIGYKRTMALSFAIFAAAFGLFILAAKQNSLTWFLIASFVSGAANAVLQASVNPYVTILGPMDSAARRISCMGISNKLAWPVTTLFITLVIGKGIGDTQLTDLYMPFTIIIGIFLLLGVIALMAPLPDVKAAGEDESECGDEAAVSSYADGKTSILQFPHLLLGCLALFLYVGVETISLATATGYAQSLGLEGDNYGFIPSVGMIVGYICGVIFIPRYLSQAAAMRICAIIALVGSVAVAVVPDPVISVYCIFLMALGCSLMWPALWPLAMADLGKFTKSGASLLTMAIAGGAVMPWLRGVVQDCTSFQTSYWVSVPCFLFILYYGLAGYKIRTKKE
>NC_014371.1|WP_108235565.1|1138343_1141823_-|DUF4981-domain-containing-protein
MWTQSIANPNQQIYITKKGSGYKLSAVSARNGQTYYVTFGSISSVDGYYCGYENSEASAATLQFKEVPAVVIPEGADWENAKVYERNKERAHATYMPYPSTKAMKADGQRYDKPWLDPTGANYLSLNGTWKLRWSEGAKPVLLGKDDFWGDGVSTEGSAWNDITVPSCLEMNGYGLPMYVNVDYPFEDQQPYVRMKAGLKNSVGSYRRDFTLPAGWENKRVFLHFDGIYSAAYVYVNGNEVGYTEGANNVSEFDITKYLRTGKNNVAVQVIRWSDGSYLEGQDMWHMSGIHRDVYLVATPKTYLADHYIKATVTPGSTTVATGSAATSVDLTVCNRDKTAAKKTVTVTLFDPSGKEVKKLKSDFVFAAGDSLKTQTVDFGTLSNVKLWSAETPTLYTFTFSQSQDGKEEEAFSTKYGFRKIDLSKGYLEVNGRRTYLKGANTQDTDPLHGRSISTDLMLKDIAMMKQSNMNTVRTSHYPRHAKMMAMFDYYGLFVVDEADMELHKNWDGVKTIINNTDWTGAIVDRNVRNTLRDRNHPSVVFWSLGNESGSGLNIMAAYNAVKELDNRYIHYEGSTRDNAEGTDLHSVMYPAVDHSRGGTTGPVTSDANHPSTGKPYFMCEYAHAMGNAVGNLREYWEAMEGSLMGVGGCIWDWVDQSIYSYDAIKNNQLTKNGFPAYITGYDCPGPHQYNFVNNGLVNADRAWSAELDEVKRVYQWVGFNLNKDTHQVKLTNKYLDRNLNQFYLKWTLLADGKPVQDGIVKKLNCAAGGTETVDLKYNPTAFAGKELFLNIGLYTKEATNWCDRDYPVAEFQQQLAQRTEVLDKVDNTKADALHATKNSDGGYTYANGKQKVTFDGQGNITLWAYEGKDLFVQNEGPRFDRYRWIENDNPMEAYGNDPTDNGVKSQTATFQLSDDGKTATVNVTQNGNYGKATYKYTINANGTIDLASSFEAQGNGARRLGFSLNFPSDMSKVSYYARGPRASYIDRLDGEDFGIYETTVKDMYEPFAHPQSNGNRIGLRWLTLTNNEGNGVKVETSGDVAFSLTPWTEAELRTARHEWELPTSNRVVAHFDAIQQGLGNKSCGPGPLSKYEIQKGKTYSNIVRFIPFSETADDTANGISAVVNSATTMAQVYDLSGRRLPEPPAKGFYIQSGKVHAN
>NC_014371.1|WP_013265712.1|1142244_1145736_-|glycoside-hydrolase-N-terminal-domain-containing-protein
MNICKRLCAAFLLSVVCVGQVFAQGYPRISTKGNEHWYYVKYLRSNNVLEDKGEKQKCLTAVPQVMNGGRQLWKVVAAENFGRNKKYQLVSKSGRTLYVNGTNPYSSRFMAATKATDITSFHIFQSMNTSFGTGAFELAPDSTNSHAMNQVGEIRAGQEIGLWDKGDINNVLTFVSKDDMEFPYYMPVISTAANPVYYYIQFQTGNWLLSAKGDKATCQTASLHNGNLDDMLWRVSEKDGKYSFVSKSGKILYISDSYVNAAKAHNVKDTLFTMVESNNSLGGFEIGKSTTGRNFFNMFQGAGEGRLISFWDLGDGGNVVRFVPAEALVPVSGITTFNPANKYTLWYTKPATNWMTSCLPIGNGQFGATLMGDVAIDDVQFNDKTLWSGKLGGLTSTAAYGYYLNFGNLYIRSRGMSKVTDYVRYLDINDAVAGVKYTMDGVAYSRTYFASNPDSCVVVRYTASQNGKINTTLTLKNQNGRNVSYTVDNNNQATITFDGQVARQDDHGATTPESYYCAARIVTDGGTITKNAKGIIEVNGANSMTVYLRGLTDFDPDAPTYVSGANLLAGRAAATVNDAQNKGYDALLAAHKADYKSLFDRCQLTLSDVKNNIPTPQLISSYRDNQHDNLFLEELYFNYGRYLLISSSRGVSLPANLQGIWNDNNTPAWHSDIHANINVQMNYWPAEPTNLSELHRPFLDYIYREACVKPTWRRFAQDMGHVNTGWTLPTENNIYGSGTTFANTYTVANAWYCQHLWQHYTYTMDKDFLRAKAFPAMKSAVDYWFKKLVKAADGTYECPNEWSPEHGPTENATAHSQQLVWDLFNNTRKAIKVLGDDVVSKAFRDSLATYFAKLDDGCHTEVNPADGQTYLREWKYSSQFNNPSKIGVNEYKAHRHISHLMGLYPCTQISEDADKTVFEAARQSLIARGDGHGTGWSLGHKINLNARAYEGQHCHNLIKRALQQTWDTGTNEAAGGIYENLWDAHAPYQIDGNFGYTAGVAEMLLQSHNDKLVILPALPTTFWQKGSVKGLKAVGNFTVDIDWAAAKATKVQIVSNMGTTCIVKYTNVAKDYKVTTADGKTVKAKRINDDEISFPTVKGGVYVIVSKTADAIAAIQKAQDGNIASVDYYSLNGTKTSQSQSRGVYIKQMKYSNGTTSTTKVIN
>NC_014371.1|WP_013265677.1|1146597_1146996_+|hypothetical-protein
MKKVTIIVEQASDGSYWCRTAEDIAGIGLNSCGDTVEQAKQDLIDCYQEAKEDLEEQGKTMPVVEFVYKYDLQSFFNYFSFLNVTEIAKRAGINPSLMRQYNSGIKNAGEKTYERLAACLDGIKAELQAASF
>NC_014371.1|WP_013265534.1|1147414_1149115_-|family-10-glycosylhydrolase
MKKLFLFTLLCVITMTTQAQTNLSDYLTKRMPKRETRAVWLTTLASLDWPKNYARSEESIKLQKQELIDILDKYQKANINTVLLQARVRAATIYPSDIEPWDQCITGVEGRAPGYGYDPLSFAVEECHKRGMEIHAWIATIPVGAKNSLGCRTLMKKGFRIRNFSTGSYLDPADPSVAPYLASVCGEIVRKYDVDGINLDYIRYPDGWPRPSYRDGDTPDQRRSNITAIVRAIHDEVKAIKPWVKMSCSPIGKHADLSRYSSKNFNAHDRVSQEAQEWMRLGLMDQLYPMQYFRGDNYYPFVADWVENAYKREIVTGLGTYFLDPREGNWTLGDLTRQMYVSRDLGVGHAHFRSYFLTANKQGVYDFEKQFNATLSLPHKMQGVVSTAAMPYAVNSSLVERREDKSVILRWKAVTPYYNIYASYTYPVDTEDARNLLFARYTGQTLQLKNVNPNLYFAVRGMDRYGLETPALQENMKSTSLSKSPATLLANDGNTLTLPAAAKLTDADRYVILSLQGVILRIVNAKSVRNNQLYIGSLSDGMYSLKVYNHKKKSFTLGAFMVRRGS
>NC_014371.1|WP_013265399.1|1150057_1150489_-|NUDIX-hydrolase
MYTYNYPHPAVTADCLVFTRTDEGMKLLLIQRKNEPCKGKWAFPGGFMDIDETTIDAARRELKEETGLVVGELHRVGIFDAVDRDPRERIITVAYYTILDKPAEVSGLDDAAQAKWFSLTELPDLAFDHKEILQEAERVLGDG
>NC_014371.1|WP_036924016.1|1150505_1150718_-|DUF3791-domain-containing-protein
MDQKTLEFVTYCIGKLSVMLKLPQQEVYRRLKTSGILDEYIVPSYDVLHTFGSRYLMEDLTEYMKEKGVL
>NC_014371.1|WP_044046127.1|1150897_1151710_+|GSCFA-domain-containing-protein
MEFRTIVNIPRPTFELEPCERILFVGSCFADNIGKRFEEEKFRAMVNPFGVMYNPVSVLHTVKKVANHTFDTAVFTLGTNHVYVERATGEIVDNCQKRPQREFEERELTVEECADALREAITLLRQANPKVNVIITVSPIRYAKYGYHGSQLSKAVLLLATDKVIKEEGERIYYFPAYEIVNDELRDYRFYKADMLHPNEQAVEYIWEQLVATCFSAEAKQFLEEWRPIKEALAHRPFHPEAAAYQDFIKKTKEKAKMLELKYPNIELNL
>NC_014371.1|WP_013265396.1|1151721_1152153_+|transcriptional-repressor
MNDKQIEALLKAHGIRLTANRILIARTLSGLDNPASIKELEAKIQTIDKSNIFRTLSLFKQQHLVHQMEDGNDIVRYELCLSDDDEEDEDMHVHFYCERCHRTYCLNDIHIPQVELPAGYEQSSINYMIKGVCPKCAHRYYIK
>NC_014371.1|WP_013265819.1|1152236_1154717_+|bifunctional-UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine-ligase/alanine-racemase
MNYTIEKVTTLIGARRYGDKDANISFVLTDSRSLCFPEETLFFALKTERNDGQNYIPELYARGVRNFVVEVVPEDWATRYPDSNFLKVVGSLEALQRLAERHRDEYLIPIVGITGSNGKTMVKEWLYQLLSPQMVVTRSPRSYNSQIGVPLSVLLLNENTQVGVFEAGISQPGEMMALRDIIQPTIGVFTTLGTAHQENFPSLEAKCHEKIKLFHDTEAIVYSADNEVMAQCLSQYDYKGQKLDWSVKNTEAAFYIKAIEKKDIETTVSYVWKGQTEGQYKLPFIDDASVENSITCAVVSLHLGLTPATISERMAQLEPVAMRLEVKEGQHGCTLINDSYNSDFNSLDIALDFMNRRPDHKGRRRTLILSDILQSGDTDKDLYNKVAFLCEKRGVEKFIGIGEGLLAQRSAFKHLGEKHFFATVNSFIHSDVFANLHDEVILLKGARQFGFDRLTELLVKKVHETVLEVNLNAVVDNLNWYRSFLKPTTKLVCMIKADAYGAGAVEIAKTLQDHRVDYLAVAVADEGVTLRKNGITSNIMIMNPEMTSFKTLFDYDLEPEVYSFRLMDALVKAAQKEGITGFPVHIKLDTGMHRLGFDPQKDMDELIKRLKQQNAIIPRSVFSHFVGSDADNFDEFSAHQFALFDEGSKKLQAAFSHKIIRHMDNSSGIEHFPERQMDMCRLGLGLYGINPRTNKTINNISTLKTTILQLRNVPAGDTVGYSRKGTIDRDSVIAAIPIGYADGLNRHLGNRHCYCLVNGQKAEYVGNICMDVAMIDVTGIDCKEGDSVEIFGDHLPVTVLSDTLDTIPYEVLTTISNRVKRVYFQD

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Crispr_ID: NC_014371_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014371_6

1189574-1189684

Orphan

Consensus_repeat	Method
AACTACGAATTTCACTAATTACGCTAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014371_6

>merge|NC_014371|6|1189574-1189684|CRISPRCasFinder
AACTACGAATTTCACTAATTACGCTAAACTTATTGCTATATAATTCGTGTCATTCGCGTAATTCGCAGTCAACTTTTTGATTAGAACTACGAATTTCGCTAATTACGCTAA

>NC_014371|6|6|1189574-1189684|CRISPRCasFinder
AACTACGAATTTCACTAATTACGCTAA	ACTTATTGCTATATAATTCGTGTCATTCGCGTAATTCGCAGTCAACTTTTTGATTAG
AACTACGAATTTCGCTAATTACGCTAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_014371.1\|WP_044046130.1\|1167254_1167677_-\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_013265067.1\|1190892_1192053_-\|DUF1735-domain-containing-protein	unknown	unknown	gnl\|CDD\|378016
NC_014371.1\|WP_044046134.1\|1201399_1201594_+\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_013265122.1\|1198853_1200758_+\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_013265696.1\|1192069_1193161_-\|endoglycosidase	unknown	unknown	gnl\|CDD\|374390
NC_014371.1\|WP_004360559.1\|1168750_1169062_-\|T9SS-type-A-sorting-domain-containing-protein	unknown	unknown	gnl\|CDD\|275036
NC_014371.1\|WP_013265755.1\|1194778_1197880_-\|SusC/RagA-family-TonB-linked-outer-membrane-protein	unknown	unknown	gnl\|CDD\|274948
NC_014371.1\|WP_013265651.1\|1174439_1178177_-\|T9SS-type-A-sorting-domain-containing-protein	unknown	unknown	gnl\|CDD\|227068
NC_014371.1\|WP_013265785.1\|1169680_1170196_-\|HutD-family-protein	unknown	unknown	gnl\|CDD\|377578
NC_014371.1\|WP_013265220.1\|1183722_1187100_-\|SusC/RagA-family-TonB-linked-outer-membrane-protein	unknown	unknown	gnl\|CDD\|274948
NC_014371.1\|WP_044046131.1\|1167696_1168089_-\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_013265884.1\|1168156_1168705_-\|RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|224511
NC_014371.1\|WP_013265496.1\|1178604_1181634_-\|T9SS-type-A-sorting-domain-containing-protein	unknown	unknown	gnl\|CDD\|227068
NC_014371.1\|WP_013265363.1\|1181733_1183566_-\|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein	unknown	unknown	gnl\|CDD\|372283
NC_014371.1\|WP_013265813.1\|1170465_1174239_-\|T9SS-type-A-sorting-domain-containing-protein	unknown	unknown	gnl\|CDD\|227068
NC_014371.1\|WP_013265852.1\|1193196_1194747_-\|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein	unknown	unknown	gnl\|CDD\|372283
NC_014371.1\|WP_044046132.1\|1198546_1198747_+\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_044046135.1\|1201717_1203547_+\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_044046218.1\|1189865_1190873_-\|discoidin-domain-containing-protein	unknown	unknown	gnl\|CDD\|366285
NC_014371.1\|WP_044046136.1\|1204319_1204793_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_014371.1\|WP_013265755.1\|1194778_1197880_-\|SusC/RagA-family-TonB-linked-outer-membrane-protein	gnl\|CDD\|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
NC_014371.1\|WP_013265067.1\|1190892_1192053_-\|DUF1735-domain-containing-protein	gnl\|CDD\|378016	pfam08522, DUF1735, Domain of unknown function (DUF1735). This domain of unknown function is found in a number of bacterial proteins including acylhydrolases. The structure of this domain has a beta-sandwich fold.	4.6622e-23
NC_014371.1\|WP_013265696.1\|1192069_1193161_-\|endoglycosidase	gnl\|CDD\|374390	pfam16141, DUF4849, Putative glycoside hydrolase Family 18, chitinase_18. This DUF is likely to be a form of glycosyl hydrolase from CAZy family 18, possibly chitinase 18. This would have the EC number of EC:3.2.1.14.	5.25885e-73
NC_014371.1\|WP_004360559.1\|1168750_1169062_-\|T9SS-type-A-sorting-domain-containing-protein	gnl\|CDD\|275036	TIGR04183, hypothetical_protein, Por secretion system C-terminal sorting domain. Species that include Porphyromonas gingivalis, Fibrobacter succinogenes, Flavobacterium johnsoniae, Cytophaga hutchinsonii, Gramella forsetii, Prevotella intermedia, and Salinibacter ruber average twenty or more copies of a C-terminal domain, represented by this model, associated with sorting to the outer membrane and covalent modification.	0.000439819
NC_014371.1\|WP_013265651.1\|1174439_1178177_-\|T9SS-type-A-sorting-domain-containing-protein	gnl\|CDD\|227068	COG4724, COG4724, Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism].	5.80848e-36
NC_014371.1\|WP_013265785.1\|1169680_1170196_-\|HutD-family-protein	gnl\|CDD\|377578	pfam05962, HutD, HutD. HutD from Pseudomonas fluorescens SBW25 is a component of the histidine uptake and utilisation operon. HutD is operonic with the well characterized repressor protein HutC. Genetic analysis using transcriptional fusions (lacZ) and deletion mutants shows that hutD is necessary to maintain fitness in environments replete with histidine. Evidence outlined by Zhang & Rainey (2007) suggests that HutD functions as a governor that sets an upper bound on the level of hut operon transcription. The mechanistic basis is unknown, but in silico molecular docking studies based on the crystal structure of PA5104 (HutD from Pseudomonas aeruginosa) show that urocanate (the first breakdown product of histidine) docks with the active site of HutD.	5.10476e-20
NC_014371.1\|WP_013265220.1\|1183722_1187100_-\|SusC/RagA-family-TonB-linked-outer-membrane-protein	gnl\|CDD\|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
NC_014371.1\|WP_013265884.1\|1168156_1168705_-\|RNA-polymerase-sigma-factor	gnl\|CDD\|224511	COG1595, RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription].	3.7543e-34
NC_014371.1\|WP_044046218.1\|1189865_1190873_-\|discoidin-domain-containing-protein	gnl\|CDD\|366285	pfam00754, F5_F8_type_C, F5/8 type C domain. This domain is also known as the discoidin (DS) domain family.	1.61729e-09
NC_014371.1\|WP_013265363.1\|1181733_1183566_-\|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein	gnl\|CDD\|372283	pfam12741, SusD-like, Susd and RagB outer membrane lipoprotein. This is a family of SusD-like proteins, one member of which, BT1043, is an outer membrane lipoprotein involved in host glycan metabolism. The structures of this and SusD-homologs in the family are dominated by tetratrico peptide repeats that may facilitate association with outer membrane beta-barrel transporters required for glycan uptake. The structure of BT1043 complexed with N-acetyllactosamine reveals that recognition is mediated via hydrogen bonding interactions with the reducing end of beta-N-acetylglucosamine, suggesting a role in binding glycans liberated from the mucin polypeptide. Mammalian distal gut bacteria have an expanded capacity to utilize glycans. In the absence of dietary sources, some species rely on host-derived mucosal glycans. The ability of Bacteroides thetaiotaomicron, a prominent human gut symbiont, to forage host glycans contributes to both its ability to persist within an individual host and its ability to be transmitted naturally to new hosts at birth.	8.49259e-102
NC_014371.1\|WP_013265813.1\|1170465_1174239_-\|T9SS-type-A-sorting-domain-containing-protein	gnl\|CDD\|227068	COG4724, COG4724, Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism].	4.64381e-48
NC_014371.1\|WP_013265852.1\|1193196_1194747_-\|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein	gnl\|CDD\|372283	pfam12741, SusD-like, Susd and RagB outer membrane lipoprotein. This is a family of SusD-like proteins, one member of which, BT1043, is an outer membrane lipoprotein involved in host glycan metabolism. The structures of this and SusD-homologs in the family are dominated by tetratrico peptide repeats that may facilitate association with outer membrane beta-barrel transporters required for glycan uptake. The structure of BT1043 complexed with N-acetyllactosamine reveals that recognition is mediated via hydrogen bonding interactions with the reducing end of beta-N-acetylglucosamine, suggesting a role in binding glycans liberated from the mucin polypeptide. Mammalian distal gut bacteria have an expanded capacity to utilize glycans. In the absence of dietary sources, some species rely on host-derived mucosal glycans. The ability of Bacteroides thetaiotaomicron, a prominent human gut symbiont, to forage host glycans contributes to both its ability to persist within an individual host and its ability to be transmitted naturally to new hosts at birth.	0
NC_014371.1\|WP_013265496.1\|1178604_1181634_-\|T9SS-type-A-sorting-domain-containing-protein	gnl\|CDD\|227068	COG4724, COG4724, Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism].	3.66339e-33

>NC_014371.1|WP_013265220.1|1183722_1187100_-|SusC/RagA-family-TonB-linked-outer-membrane-protein
MKIFKESKQKHLYFSAAFALSLALAPTGVYAGTNTSTAVQAVQQNGNHKVTGRVVDSTGEPLIGATILVEGTTNGTVTDIDGNYTLNTTANAKLVFSYIGYAAQTIPVGGKGTIDVTLKEEANTMNEVVVTAMGIMRKEKSLTYATQQVKAEDLMKVQDPNAANSLEGKVAGITITPSAGGAGGASKIVLRGNRSILGNSSPLIVVDGVPMSNGIRGQQGMGAEGFGSTGTSEGSDPLSLINPDDIESINVLKGANAAALYGSRAANGVVMITTKRGREGKVDINVTSNITFDSPLLTPKIQKTYGAAYDKTTGALSLNNWGGKLADRADNDLVVRTPLDERWVGYPEEQIGTDASGNPIMARRHNVYLRNRAGNDVDNFFRTGVTTNNSISLSGGTDIARTYVSVANSHATGMMRNNSYNRNSISFRQTYNFFKRLHIDASMNYTESKTKNRPGGGTVGNPLYHLYTAPQNIDMDYYRDHYMNAEGKWLSNPGSYYKLNGSNFAWAAGQRTTLTGPQQEWAYLSHPNNNPYWLINSGNSQQKESRLFGTLQANVDIYDGLTFQARVNYSQIRFKNHATRFATTFLPASMEDYGRLWDSDEKTTEFYTDYLLSYNKTFGDYSVSATAGYVGHTIKGESKGTDAVATYYDRLMRKLPTMVNYFETSAGGYGVTSTSKSSNWDRSYLFTAQLGWKETVYFDASYRRDWYRPFRYFKELGKIDTDNYGYFGVGANAIVSQLVKLPDWFNFLKYRVSYSSVGNSIPNKAYGAMSRNLQTGALSGNKLLDFSPVPEETGSFETGIESLFLNNRLSFDFTFYNTIVRHLYMELGSLGGNTELLNSAKVRNTGFETTVGYDFKFGKDLRWRTSYNLSYNDNKILETGYDKDGTSRKYQQTVGEAKVIYQKGGAIGDIYAGDFMRDANGHIVLTAKGEPTFDKTGSNDRFLGNMNSKWQMGWTNTFNYKEFQLSFLINGRIGGKVLSLTESYLDYIGASERTEAARLSAERNNIVATNYGNVPGMELNDGSGRIVPIQSYYQALGASSNPSTYLYNGTNFRLRELSLGYTFRDLFGMNRNLTLSFIARNLFFIYKDAPTDPDVSLSTQNGLGAFESFNMPSSRSFGFSLKANF
>NC_014371.1|WP_013265363.1|1181733_1183566_-|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein
MKSKHIIVLMAMALPTLGLQSCLDYDNPGDEFNSTTKNVEKVTSRGDVDKIPFRQATDAAAADEALNAMQDLLDAGVGGQFSMRGGKNGENPGPHAYQYQYSLGVDNYAEYTVIPHTFFQYSKIRLASSYAIDQKCYGGAWGSFTEMKTSLVPILNNEKVNAVPELKAAYLTLFNQQAVEVADVYGPMPYRELKTNLQVGPYTYNKVEDVYNDAVANLDTAIACFHYFDQKPAAYKQKIKSAFVDRFVVMTDGGAADGTLKAWARYANSLKLRIAMHMVKSDPVRAQKLAEEAVADGVIENEAQSVSIRPGVMGFSHPLPGVESWGDARMSATMEITLKTFNHPWLKYLFKKNDNVIKNNKTGETTPADSRICGIRTGTHPGEGQGYDENQYIAFSKLNEQYFNSAPLYLMKYAEVCFLRAEGALRGWNMGGSAQHFYEEGIRHGNCEDPEMKSMDGESPNGQQNVNWYDSWIDTYMAQENPVAYVYKDPTGDTPDAASPIHVGVKWNDSDSQETKLEKIITQKYLATYPNGFEAWVDLRRTGFPRMLPVLNIDEADGSLVPGDIMRRLPFPGTSDIATKQDVDNTGIPALGGPDKMATRLFWDKTTSNF
>NC_014371.1|WP_013265496.1|1178604_1181634_-|T9SS-type-A-sorting-domain-containing-protein
MNKKSTLSAWIIAAMMAMAPAGVTAQTYSSTASTQVFDLSKLGDQTLLEHFAELLDNGKKYPTDADLTAWGIKDEVEFIRSHVRKRAIESRADRLLQDTYENRNLFMNIPGGAGKNLGGYPSKTFANDNFSMWNYTNLFGAWNYGLFQAPGSWADAAHRNGTSIFAGIKFFDHTTGGAANSWASFIMKRNTDGSFRYTHPIINCMRFLGFDGINYNWESTNKYQDADNIAFHKELYKIAKSEGFNDFKIMYYTTSSRLTSYNSSYMWGQDKDNRICEVMLNYDNSDFSWSMGESVREAERTMGSADGLYAGVWIVSMDRRWNSLNNQDAKRCGICLWGEHAESRFWSYNTGGDAMSRMSNYQEYLERAFSGGNRNPLYRPEVSNRGNNVEAQGTTPPLARFAGLASWIPERTAISGNLPFATHFNTGNGERYNYKGKKTAGSWYNMSSQDVVPTYRWMVVKPETEVASTDVQPSFTNEDAYTGGAALRLKGVNNATATDVVLFKTNLTPSKGKVVAKVAIKTGKEGNNDSKLSLIVRVNGAWKAYALGNTENANWTEKKVELNDITAGQKIERIGLRVKDSDADYNVLVGKLELNDDVTATPANVKDLTVQVKEETKNSLSVKAVWGIDKDPGQNPTVYNDEANIDHFEILYKNGENGKVSEVGRTSQWATLVPNIQFTSVDDKPFIGVRSVSTDLKTYSKTKWIAVPRAQQSELPEAQEEGYGTVELDNAAAGAETARKIRYVQKFQTEGGSKNIDYTANGPAGNETNYVDATSQELEVAQGATVKVKIKGYEATQMKDQSNDDLRYCMGKAWMDFNGDKQFNPENLSENPNEGECVVFFGQVRKGVPAQVQQLNEYTFKVPEDAKPGQSRLRLVFCDAWFQGGLTPTGKFNKGFAIDFKVTITGSNAARGAKADTHDKGVADEPELLEGGSTNIISANVGGASQLTVVGGKVVFENVERAWVFSTDGQTVKSLVNPKSFNTNELPAGVYLVKMQNNNVIRTQKITIK
>NC_014371.1|WP_013265651.1|1174439_1178177_-|T9SS-type-A-sorting-domain-containing-protein
MRRINLLLFGCCLIPSTLMAQELKSNYIQWGFESQQFPGKLQSWSKSNPKINDDDNFFISRVKPKARFRYEGTQVRTDLTETNDKKLLAWLPWNVPSKNALPDGVFDSEVFSMWPYVTHWGDWNCGLGRIPAALLDAAHKNGVPVSSVAGIPYGGLSGAWSSALEQLATTDVQKAAAYMNYFGYDGLGYNSEYSEYFGGGRITRKLRDFHVDLNKAIRPTNPIYENIWYDGTNDKGRISFDHGLNEYNKSIFGAKGSEAANLFFNYNWNSSTLLQNTVEMAEEIERNPLDIYAGINMQGGEPRTGSRWTLLKNYPISIGLWGAHSQNMFFESRGEKGSDPETQQRTYMLRTERWFSSGSRNPVNSLQINNSLNYNADNTDFAGMSAMMTARSSMSWDLTQEPLITYFNLGNGKFFNYGGVRKNDRPWANVGVQDYLPTWRWWFASKLLGRTAVDVPATGLDAEFVWDDAYMGGSTVRVHGSTPKEYLHLFKTKYALKTGDVITFRYKVKGGKADASLVFATEDNVNAEKAYPVLTTADEADEDKWVEKTITVDGTLNGKTLALVALKMENAADLNLYLGEFSIVRGSFDAPAQPIDVKTTLLHAAKNGVDAKIIFNMPNTKGQGEPCYNTDVKTSLFKLWAKQEGKDPILMGVTTSWAGMFYSVPVDLKGQGKVKFGVSAVSLDMKKESAIAWGEDHEIFNSYEYSDEIKADKSVIKPNEAFTIAYVDPRHEAGNWKIEQNGATVASSNNANEIKVENGLSQTGFYDLVLTGAVNENGARVNKEVRYANYIQITSDAVGAVPHINKLTANNSETSIEVVANSEVTMKYEGKKADGSGSRGIKTLEKPVGVKVSELGLTSNNQAWTLAFWVKFNGFTGNTQIIDMRDPGTGWPQNNWGTMWTTYDPNTGVYEVTLREKNAGGAKEYKQRWEVDFVPGAWTHFVLAMEGNGTTTKPMVYINGKAAKAHNWEYDGHKGDGINPDGFANNAWWDNNVLGISLGRAGAAAINGTVDDVKFFNKALTAAEAAHTMMSTDANEAGLKAYWDFEADADASHYFTSKVGNAKLAHGELKAGEGEGVTTLVPDAPTYDAGSAFVSGTFQVKTTAEWTAKKATIVSQDGTDMAGTAKLKYAKAGDYEVTLTLKNAHGSDTRTFQVIKVKADPTGINGTETADMKVYAIDRDVLFDVETPGNYLVQVFSTNGQMVASKAVSVNGAESVRLHLGAQGVYVVNVKKDGKTLRTVKFICK
>NC_014371.1|WP_013265813.1|1170465_1174239_-|T9SS-type-A-sorting-domain-containing-protein
MKRITLFASLALASCLTVSAQRTPTHPLDIQDAKFENLPNYLEAWLKGEMKQPQGVSEIDDQFFISRVRPLERIKDGDYQVRQGVKRDRKMCLWTPLDDPTAQWKALPRYCFEGDNFSLWSYIDIHGNWTSPWIRSTAGLTDVAHKNGVSVGCVMSIGYGAYIYLNQWRPDTYSKTLYKLTKKEGGKFVYAAPLVRMMKYYGVNGIGFNSEFRTSSDVMATLTDFFVACHKEAEKINWKFEVHWYDGTGDDGSIHFDGGLGSHNQNIFGDKDHIATDMLFANYNWGPSHLRGSVSTAQRLGRSSFDYYAGFDIQGRGLRQPSWSALLNNDISIGFWGAHSQSLIHQSATDNGTSDIAIQKTYLKKQELMFSGGYNNPGLLPAINTDCNLANASLKNFHGLATFLSAKSTIQQVPFVSRFNLGNGLSFRKDGKVTFNHKWYNLNTQDYMPTWRWWITDGADQVNTGNINSLAKAELTFDDAYWGGSCLSISGQTDFSRVKLFKTMLEVQPDYEFSVTYKTIAGKDTHAKFFVALKDHVTEYKEVALPAVEAEGKWNTFTVKASELGLAAGDKVAMMGLVVENTPANYELRVGEMALRDNAKDFATATPTIKKVEILRGRYNACDFKMQYASKEESGWEKTYNDEVGTWYYEIYFQQKDQPQQLLTATTSWAAYVVDAPMVSGADKRDCRFGVRAVSPDGKKGSEIVWSDYQTVAYDQPLSDVVADRPVIKPNEEFTLKYLDEMVPAAQAWKLQDAVTGQVVAQGESGTSAKFTVAKEGTYDLVVVDNNGKESVVRGKVKITPEATGAVPQITDITADKTTEKVGQNVTYTYEGRLGEGKASRGLEITDPKMFRIPGDVQQGKSYSYALWFKADKFNHDKQGTNLINKNSIYDSWPHNNWGDLWVTIRPEWQGSRALHAANEISFNTMGWTAHDNPYEDVMTTGYSVTPGVWNHIVVTHTDGNIQKIYFNGRQVASHSFAASSRREDYGDRRINASKVADIFIGGGGVYKSGFNGIIDEVQVWSKPLSDDEVLRAMKGYKEGEVPADLKAYFTFEDVDGMKFKNIGSAGRTYDGSVVVVSGSGGENTSSAAYVDQQPNNNVLGFPGVVGTYEIKTVPTWALGDGQISSSADKTAVVTYAAPGKKNVTLKLKNGWGEAEKTVEEIVEITSEANAIDAVDAQLGFSVYPNPFVESVNMRFAENGRYTINVLGTTGALLQSNSFEAAQGQVVNVAITGTKGMYLVQVLKNGKVYKTVKVIKR
>NC_014371.1|WP_013265785.1|1169680_1170196_-|HutD-family-protein
MTTLPQSSYKTTTWKGGVTRQIFISPADGDLSARQFDVRISSAIIDDVQSVFSDFSGFTRYILPLEGEITLIKEGRRIVLSHNDLYEFEGDEKVSSENTQGAVDFNIIVRHGISVEVGIVEDAAFTDSRRTIVFALEDCCIEGKTVRKHDTALLDEPFSLKGKAVIARFME
>NC_014371.1|WP_004360559.1|1168750_1169062_-|T9SS-type-A-sorting-domain-containing-protein
MIKNIFTPFLFTLLLSVGFTAPVQARAAIDLIDLDVQTISISVVGNVLHVVGAENEQLAIYNVTGVRVMSVKVDGDDKHYTLNLPKGCYIVKVGNVVRKVSIR
>NC_014371.1|WP_013265884.1|1168156_1168705_-|RNA-polymerase-sigma-factor
MTPLDEAEVIRLLASFEGRQKVFPVIVDQYSQSLYWKIRSIVLTHEDADDVLQNTFLKAWKSLPTFQGKAKLSTWLYRIAINESLDFLRRQKAATLSSADADLSVANRLLADDYFDGDKSQALLQEAIATLPDVQRTVFTLRYYDEMKYSDISEILGTSEGSLKASYHIAVQKITDYVKRYE
>NC_014371.1|WP_044046131.1|1167696_1168089_-|hypothetical-protein
MESTNHLQKEYGTQRPFTVPENYFSELSSRVMAQIPAEEQKEAVVAVKPHRTMVHYLRPLAAAAMTIGVVLVGFLAYHEFDGEQGKHALAEGHLAQGAHETSASSEDEFDKAADYFMIDESDMYAYLASE
>NC_014371.1|WP_044046130.1|1167254_1167677_-|hypothetical-protein
MKHKRIILLFCIFFSVSLLHAQGKFDFNRIKAESHNFITKEAGLSGQEAARLFPVYDEMRGKQRVYFDKLRAIFSAKPSSEREASKTIEQADAYEIQLKQIEQRYHKEMLKVLPATKLLRVLEAERRFHRQTFRKMAGRR
>NC_014371.1|WP_044046218.1|1189865_1190873_-|discoidin-domain-containing-protein
MKIKVFKSVLAASLVAATLASCQSEPEVGSTLYPTAEENYSAKAYLYTGTSDGNKLLLAGEKSASTVTLANDSAKFYVRLSSPAEKDVTVTLAATSDGVEANSSEEVMSTDAISLSKTSVTFAKGQQVSEPIVVKLVNGDALKNLAMLKNGVTSVVIKSVDGAETAKTNTKVLVTTNFTFNNINASGTLNADKQIALNEYQMSTTLSSSNAAKLNDGDNNTYVYSYTYYEPEFTMAFNSTKELIGVGILCNYTSYGYGVKKVAVATSLDGKTWTNMGTATAASTYDDDTPFPIVFNTPVTCKFVKLTILQSFDESENPRFLIGEIGAYEYLDWNL
>NC_014371.1|WP_013265067.1|1190892_1192053_-|DUF1735-domain-containing-protein
MKYNISKLFIGAVAMASLTLLASCENAEYSPLSNQAYIAQTNTNGNSSQNITIGTSAVTSSVNVRLSDLATQDYTFEVVSDTTALAEYNQRNETSYKPLPASLYSLSSNEVKIEKGKSVSSDVTLTINPLTQALKDSGQKYAVALRLKSKDGKYDVLNSGSSMVYILDQVVYQAVPIINATHNIHFAMRQTYDLSQWTVEMNVNISKLGKGLGELNNQTLFGAWGNDGGEIYTRFGDAPIEGNRLQIKTQGTQMNSKQLFNENQWYHLAFVCTGTKLYLYVNGALDNSMDLPGKATNLSNRINFGNTDYLKANVKVSELRFWTVARTQAQIANNMYACDAKSTGLEAYWKLNEGQGDTFKDATDHGNTGKCVAVPTWEQNVRIDGK
>NC_014371.1|WP_013265696.1|1192069_1193161_-|endoglycosidase
MKNLIKIFLLSACAATAFTACSDWTETEAKDGADLTHTNKSEAYYAQLRDYKKTDHSVAFGWFGNWTGTGVTHENSLAGLPDSTDFVSLWGNWKNPTEAMLKDLRFVQKTKGTKVLISCLVFDIGDQITPTNTDSTLTWKEWRHKFWGWGNDEASQIAATEKYANAICDTIAKYGYDGFDLDAEPSYAQPFQTDKELWQNAKVMEAFVKTMGKRIGPKSGTDKMFVIDGEPDAMAAQYGEYFNYFILQAYSSSGNSDLNSRFTAQATHFQQYLTPEQVANKLIVCENFENYAGKGGVSFRLDNGTTLPSLLGMAYWNPVYNGVTYRKGGVGTYHMEYEYTVSGQTGNYPFLRKAIQIMNPSIQ
>NC_014371.1|WP_013265852.1|1193196_1194747_-|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein
MKKINIYKAVTACTFASVLLCSMSSCTDGFQEANRPGTGASLEDLSRDNYQTSSFLVQMENEAFPEQENAYQMNEDLIGNYLGRYMTYANNGFAEKNFARLNAPNGWVRYPFKDSMTKTVSAFKAIDNVTKGEGPVYAWALILRAQSFMRLTDMYGPLPIGADATDGNAYSSQEDVYKSIIADLNKATDVIKPLVASNPNVTIAEELDKVYQGKMAKWLKYANSLKLRIAIRIRYVEPTLAKQLGEQAVQDGVITSNDDNCAIAYTPNGQYKTSVEWGDSRACADLESFLTGYNDPRLTKFFTPVEGGIRSVIGCRAAAKIGNKTTAGKAYSAANIKIDSKGVWLTASEMAFCRAEGALAGWSNMGGSAKDLYEEGVKLSFEQWGAGSATAYLADNTSTEKNYVDPISEYGGDVSAVSNITIKWDDSATDEQKMERLITQKWIAMFPNGQEGWSEIRRTGYPKVFPLAQSTDYSIQVANRIPFDIDEATNNKANYIKAVQLLKGNDDYATKMWWQR
>NC_014371.1|WP_013265755.1|1194778_1197880_-|SusC/RagA-family-TonB-linked-outer-membrane-protein
MRKGKILPVSVFLSCCSLTAFASSHVTSADNFGKNVVVAATKANTAKVLGTQQSSGDVKVTGTIVDNAGDPVIGATIRVKDSQHGTTTDLDGKFEIMTHKGATLIVSYIGMNTEEVKVSGDAPLNITLKAEAHQIEEVVVTALGIKRSEKALSYNVQKVGGENLTTVKNPNFMNSLSGKVAGVNINASSAGMGGAARVVMRGPKSITRSNQALYVIDGVPINNTSQGEISGGAFSSQPGSEGIADINPEDIESISVLSGPAAAALYGSAAAQGVIMITTKKGKEGKVSVTVSNSTQFANPFVMPEFQNSYVNRAGDVKSWGAKTPSVYGDYEPKDFFNTGTNVQNNVALTAGTDKNQTYISVGTTNAKGIIPNNSYDRYNFAFRNTTTFLHDKMTFDFNFNYIKEHDKNLTAQGQYFNPLTAVYLFPRGESFDAVRTYELYDVTRGINVQNWNFGDALSMQNPYWVANRMVRSNNRSRYMISASLKYKIFDWMDVVGRLRWDDAGTKQEDKRYASTTNLFAHSKYGFYGYDKVNDRSLYGDLMFNINKTLNDFSVSANLGGSFTRNKYNVTGFQGGLKAPSNLFTPNAIDYGSATADNRPIFTDHAHKINSLFANVELGWRSMLFMTVTGRNDWDSALDGTDNVSFFYPSVGMSAVISQMATLPSWISYMKVRGSWASVGSAISPNITSPWRYQYNPASGTYSTVTYKFPSNFRPERTNSWEAGLTSRFFNNALTLDVTVYQSNTRNQTFLRPITGSQGFSSEYVQTGNVRNRGIELSLGYGHTWGDFAWNTNFTYSANRNKIVELLDDPNEVINQGGLNGANIILKKGGTMGDLYMTSDFKRDAEGNVAIKDGNVSQVNLTNPSYRGSVLPKGNIGFSNDFSWKGFNFGFVVTARFGGIVMSQTQALMDAYGVSKASADARDKGGIAVNNGLVSAENYYAVVGGENPIWSEYIYSATNARIQEAHLAYTFPRRMLGGMELTLGLTANNLLMLYNKAPFDPEATASTGTYYQGFDYLMQPSLRTLGFNVKLKF
>NC_014371.1|WP_044046132.1|1198546_1198747_+|hypothetical-protein
MKKIYLEPETKVYEQKVEGHLLAGTGVEGSTTDPKQGGDPTSTSTTTIPNPFNSEAKEKSKWYTKE
>NC_014371.1|WP_013265122.1|1198853_1200758_+|hypothetical-protein
MEKLSKFAIVLCGTMAISLAACQTDELSDNTAGENTPKVYHVTVSADAAQGTGASTRALAVDPANGKRLISEWLVNDELAAFVNGDEGKQNNYFVLTTDRGGKSAKFIGDIAAAGRSMSTNDNISFLYPAVALKGANKTITPVERREESVAVGTVSKIISYVPSAKAQKYVSLNLSRQDGTAASLGSRFDYQCKSSHPQKVESDKLDIKIGKLQRLVSFWGLRFTDENNNKLSNIDSIYVSNIKASGILNITDNTFASDDKYEANKSIAVIPAKGTKFTSANNQYTYIALLPGNYTNVHIMVYSKGKMYEQEYANINFTADNVYHTDILHMTPVGPKPWVEVQGVKWATGNFIHYGPANGGYWGIAPAQWWISQRAVTLNNRRKVTNDKAGNTTSQFADFPTQKVEDVDLFRYGHIKEALDLRSSLLFRNSVAGKKLYYPASAGTYTDWDINGTGATRGDIAWYYTKDKHQHYRMPTGDEMKKLYTEARAIPAYCYTDKGTKVYGAYFTTSTSGGYHEFPAKRFVKSIDSYTNVTALIQANKGLFLPYTGLRDPGAVGMKMRDLSGDGNAYGQYMTTDDSKWNDRSADFFFGAAEWNWAEHPKTQAKAIRPVWDSGDNTLDSDYLNLRNSLGIK
>NC_014371.1|WP_044046134.1|1201399_1201594_+|hypothetical-protein
MRKSELMALETIATGMKVAYQKPLCAILSVEAESVICSGSVTGETENKNVSEDPSDAWYTGQDS
>NC_014371.1|WP_044046135.1|1201717_1203547_+|hypothetical-protein
MKKRILLPALCMAISIFTASCSSDDIESPEAKEQMVTLTVSAGTEDDAAATRAVLSEADAAKSPWKWEQGDKILLVSGNGSQKTVSTLSLKSMKRGGLGADFEGQVPASSVTNGSTYRFFYVGKTSDGRSDRSVDASTGSINIDLTQQTGNLADLKRNCVLTGEGKVVVSGNKATTEGSIKLANVFAVAHFAVTANNNTALTKIGLRGKGVYASANVDLSTGAVTGISEIGTEVDPEENIFFPDGKTDFYVTFVPGTVAPAFDGYYAGSHSNTEAITSTPEARNYAADKSFVYLNGQKAKFSVSATQKVAITNGNMQYVMPIATYTSAMNTKTLSANTLIRWKNSVPLKLKGSLTIHKGYYRLAPEQWEMAMPKNKRTGGSYSYSTIKINGKEYVSPETYGYFDLPSWGTIDNPTVINNTFSIRGTGTETQYDFGNKLYVGSKKTRVMTSDEWAYLMPQNTNNSNNRIWIENGKKYAKWARCFIDENGDGKRGTNPAELRGYLIFPDDMTIDEARNAFTKTPTFGGGNAINNPTTYEKIKSSGAVFIPLSAYRSRNNRTLSVWGEHGNYSTSSYVNGSMVHIRITATSSIFNDRSDPNQGCMSRLVQNL
>NC_014371.1|WP_044046136.1|1204319_1204793_+|hypothetical-protein
MMKKVNIVMKAAHLWTQEEEDRLTTRIVDNFCDLINRSEEEGLYWTGLKCDLIDLAHMVWETGRLMDKCGRPMDFQTIVHHICRVLHVREPCNPSSVISSVRARKNIRVGPLRERYLQLISKANIQDPMRLEIRKPHPPTPSPRERGSAGNNLLKNG

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Crispr_ID: NC_014371_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014371_7

1252983-1253073

Orphan

Consensus_repeat	Method
TGTGGCAAGAAATAGTAAACGGAAGCTAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014371_7

>merge|NC_014371|7|1252983-1253073|CRISPRCasFinder
TGTGGCAAGAAATAGTAAACGGAAGCTAATAAGCCTTCTTTGCCTTAAAAAAACTCTTAGATTGTGGCAAGAAATAGTAAACGGAAACTAA

>NC_014371|7|7|1252983-1253073|CRISPRCasFinder
TGTGGCAAGAAATAGTAAACGGAAGCTAA	TAAGCCTTCTTTGCCTTAAAAAAACTCTTAGAT
TGTGGCAAGAAATAGTAAACGGAAACTAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_014371.1\|WP_013265710.1\|1242123_1243680_+\|type-I-restriction-modification-system-subunit-M	unknown	unknown	gnl\|CDD\|211578
NC_014371.1\|WP_013265793.1\|1258489_1259458_-\|PD-(D/E)XK-motif-protein	unknown	unknown	gnl\|CDD\|379594
NC_014371.1\|WP_013265299.1\|1259475_1261689_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378453
NC_014371.1\|WP_013265227.1\|1247404_1248628_+\|restriction-endonuclease-subunit-S	unknown	unknown	gnl\|CDD\|341157
NC_014371.1\|WP_044046142.1\|1238357_1238576_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379188
NC_014371.1\|WP_013265102.1\|1237373_1237694_-\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl\|CDD\|226079
NC_014371.1\|WP_013265245.1\|1238616_1241460_+\|type-I-restriction-endonuclease-subunit-R	unknown	unknown	gnl\|CDD\|223683
NC_014371.1\|WP_013265709.1\|1255256_1257431_+\|LlaJI-restriction-endonuclease	unknown	unknown	unknown
NC_014371.1\|WP_013265327.1\|1249885_1250812_+\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271189
NC_014371.1\|WP_013265294.1\|1241471_1242122_+\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_013265529.1\|1257708_1258488_-\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_004359161.1\|1267123_1267645_+\|HU-family-DNA-binding-protein	unknown	unknown	gnl\|CDD\|375718
NC_014371.1\|WP_013265221.1\|1264629_1264827_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376540
NC_014371.1\|WP_009012795.1\|1245813_1247259_+\|putative-DNA-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|225420
NC_014371.1\|WP_013265666.1\|1266020_1266506_+\|peptidase-M15	unknown	unknown	gnl\|CDD\|311960
NC_014371.1\|WP_013265339.1\|1248620_1249769_-\|restriction-endonuclease-subunit-S	unknown	unknown	gnl\|CDD\|341157
NC_014371.1\|WP_013265452.1\|1261701_1263267_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|372641
NC_014371.1\|WP_013265383.1\|1243698_1245807_+\|DUF262-domain-containing-protein	unknown	unknown	gnl\|CDD\|377008
NC_014371.1\|WP_013265127.1\|1263256_1264618_-\|DNA-(cytosine-5-)-methyltransferase	unknown	unknown	gnl\|CDD\|365904
NC_014371.1\|WP_013265526.1\|1253384_1255247_+\|DUF4268-domain-containing-protein	unknown	unknown	gnl\|CDD\|379461

Protein	Function_ID	Function_description	E-value
NC_014371.1\|WP_013265710.1\|1242123_1243680_+\|type-I-restriction-modification-system-subunit-M	gnl\|CDD\|211578	TIGR00497, hsdM, type I restriction system adenine methylase (hsdM). Function: methylation of specific adenine residues; required for both restriction and modification activities. The ECOR124/3 I enzyme recognizes 5'GAA(N7)RTCG. for E.coli see (J. Mol. Biol. 257: 960-969 (1996)). [DNA metabolism, Restriction/modification].	1.25866e-146
NC_014371.1\|WP_004359161.1\|1267123_1267645_+\|HU-family-DNA-binding-protein	gnl\|CDD\|375718	pfam18291, HU-HIG, HU domain fused to wHTH, Ig, or Glycine-rich motif. Rapidly-diverging family of HU domains predominantly observed in the bacteroidetes lineage with a predicted role in recognition and possible interception of the DNA of parasitic elements, a counter-conflict strategy preventing incorporation of these elements into the host genome.	3.90955e-27
NC_014371.1\|WP_013265299.1\|1259475_1261689_-\|hypothetical-protein	gnl\|CDD\|378453	pfam10593, Z1, Z1 domain. This uncharacterized domain was identified by Iyer and colleagues. It is found associated with a helicase domain of superfamily type II.	1.07579e-21
NC_014371.1\|WP_013265227.1\|1247404_1248628_+\|restriction-endonuclease-subunit-S	gnl\|CDD\|341157	cd17268, RMtype1_S_Ara36733I_TRD1-CR1_like, Type I restriction-modification system specificity (S) subunit Target Recognition Domain-ConseRved domain (TRD-CR), similar to S.Ara36733I TRD1-CR1 AND S.Ara36733I TRD2-CR2. Actinomyces radicidentis S subunit (S.Ara36733I) recognizes 5'... CGAGNNNNNCTG ... 3'. The restriction-modification (RM) system S subunit consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. It may also include TRD-CR-like sequence-recognition domains of various type II restriction enzymes and methyltransferases and type I DNA methyltransferases.	2.50802e-39
NC_014371.1\|WP_044046142.1\|1238357_1238576_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|379188	pfam13443, HTH_26, Cro/C1-type HTH DNA-binding domain. This is a helix-turn-helix domain that probably binds to DNA.	5.70766e-07
NC_014371.1\|WP_013265102.1\|1237373_1237694_-\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl\|CDD\|226079	COG3549, HigB, Plasmid maintenance system killer protein [General function prediction only].	1.00484e-10
NC_014371.1\|WP_013265245.1\|1238616_1241460_+\|type-I-restriction-endonuclease-subunit-R	gnl\|CDD\|223683	COG0610, COG0610, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms].	5.89977e-163
NC_014371.1\|WP_013265127.1\|1263256_1264618_-\|DNA-(cytosine-5-)-methyltransferase	gnl\|CDD\|365904	pfam00145, DNA_methylase, C-5 cytosine-specific DNA methylase.	7.31567e-70
NC_014371.1\|WP_013265793.1\|1258489_1259458_-\|PD-(D/E)XK-motif-protein	gnl\|CDD\|379594	pfam14390, DUF4420, Putative PD-(D/E)XK family member, (DUF4420). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 310 and 334 amino acids in length. Advanced homology-detection methods supported with superfamily-wide domain architecture and horizontal gene transfer analyses have established this family to be a member of the PD-(D/E)XK superfamily.	5.07995e-15
NC_014371.1\|WP_013265452.1\|1261701_1263267_-\|ATP-binding-protein	gnl\|CDD\|372641	pfam13589, HATPase_c_3, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.	4.74878e-15
NC_014371.1\|WP_013265221.1\|1264629_1264827_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|376540	pfam01381, HTH_3, Helix-turn-helix. This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within Neisseria gonorrhoeae NGO_0477, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteristic of the whole family.	1.75202e-05
NC_014371.1\|WP_009012795.1\|1245813_1247259_+\|putative-DNA-binding-domain-containing-protein	gnl\|CDD\|225420	COG2865, COG2865, Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription].	4.57479e-72
NC_014371.1\|WP_013265339.1\|1248620_1249769_-\|restriction-endonuclease-subunit-S	gnl\|CDD\|341157	cd17268, RMtype1_S_Ara36733I_TRD1-CR1_like, Type I restriction-modification system specificity (S) subunit Target Recognition Domain-ConseRved domain (TRD-CR), similar to S.Ara36733I TRD1-CR1 AND S.Ara36733I TRD2-CR2. Actinomyces radicidentis S subunit (S.Ara36733I) recognizes 5'... CGAGNNNNNCTG ... 3'. The restriction-modification (RM) system S subunit consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. It may also include TRD-CR-like sequence-recognition domains of various type II restriction enzymes and methyltransferases and type I DNA methyltransferases.	1.43477e-17
NC_014371.1\|WP_013265327.1\|1249885_1250812_+\|site-specific-integrase	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	6.24457e-37
NC_014371.1\|WP_013265383.1\|1243698_1245807_+\|DUF262-domain-containing-protein	gnl\|CDD\|377008	pfam03235, DUF262, Protein of unknown function DUF262.	2.13758e-27
NC_014371.1\|WP_013265666.1\|1266020_1266506_+\|peptidase-M15	gnl\|CDD\|311960	pfam08291, Peptidase_M15_3, Peptidase M15.	5.14835e-17
NC_014371.1\|WP_013265526.1\|1253384_1255247_+\|DUF4268-domain-containing-protein	gnl\|CDD\|379461	pfam14088, DUF4268, Domain of unknown function (DUF4268). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 151 and 387 amino acids in length.	6.9822e-19

>NC_014371.1|WP_013265327.1|1249885_1250812_+|site-specific-integrase
MKTKTIREISLAWKRDKQRYVKQSTYAAYVLVLENHILSSFGDCDSLSEKLVQEFVLQKLNAGLSIKTVKDILIVLKMVMKFGVKNGWMNYCEWDIKYPTTVINKEMEVLTVTHHKKILDFIKQNFTFRNLGIYISLTTGLRIGEVCGLKWSDINTDSGIITVNRTIERIYIVEGERRHTELVINSPKTKNSCREIPMNKELLAMVKPLKKVVNINFYVLTNEEKPTEPRTYRNYYHRLMKHLDIPRLKYHGLRHSFATRCIESNCEYKTVSVLLGHANITTTLNLYVHPNMEQKKRCITQMLKYLRK
>NC_014371.1|WP_013265339.1|1248620_1249769_-|restriction-endonuclease-subunit-S
MLDFYSTNSLSWDKLEYGTNAIQNLHYGLIHVGLPTMVDLDNDKLPNIVSGNTPKNYELCQEGDIAFADASEDTNEVAKAVEFYNLNGKDVICGLHTIHGRDNQHKTIVGYKGYAFSSTAFHQQIRRIAQGTKIYSINSKNFSECYIGIPSKGEQKKIATLLRLIDERISTQNKIIDKLESLIKGICNNYFLKLSHSQEMKSIRLRDILKERNEYCCKDGTFVHGTLSKDGLFPKTERWNRDFLVKEENKKYKITHLDDICYNPANLKFGVICRNIYGDLIFSPIYVTFEISKKVNIGFIELYLTNRNFIEKIRKFEQGTVYERMSVSPEDFLSYKIRIPSLSEQTFFYQKIQRLKNCSQNELEHLNLYKKLRHYLLRQMFI
>NC_014371.1|WP_013265227.1|1247404_1248628_+|restriction-endonuclease-subunit-S
MTTTIDNEQKTLNVPNLRFPEFEGEWQEERLSDIADISKGIGISKDQLSADGEPCILYGELYTKYKSETIKEVISKTNIDNTKLVKSKANDVIIPCSGETAEEIATARCVLKDDVLLGGDLNIIRLHGYDGSFMSYQLNGKRKYDIAKVAQGVSVVHLYGEHLKNIKTINPSLNEQKKIANLLSLLDERISTQNKIIDKLESLIKGIMVELQKQGQNKGNWRNVLLSKVLKERDERNTNLYQVFSVSVSQGVINQVDYLGRSYAARDTSKYNVVHYGDLVYTKSPTGAYPYGIVKQNFNQENVAVSPLYGVYIPNSLSVGRYLHEYFRSEINTHNYLHPLIQKGAKNTINITNQRFLENSVPIPVCANELLLISKLLLSFNDKIKYQQSILQQYQKQKQYLLRQMFI
>NC_014371.1|WP_009012795.1|1245813_1247259_+|putative-DNA-binding-domain-containing-protein
MEYIDFKKLIDALTAKPKETEWLEFKHNFHSKEEIGERISALSNSSYLCNMPFGYIVFGVDDKSHDVVGTDLYGKQIMVGNEELESWLSTRLNPRIDFEIIDDFNYEDKGHVCIFKIPATINRPVSFLHEAYVRVGTITRKLKDFPAKEAKIWKGDRKSLEKIVLKKGLSGQDVFSYLSAETYFDMMHLPLPQDTNGILDRFLAENLITKDEIGYSITELGAILFAKHLSDFDGLKRKMVRVIVYKGKNKIETIREQTFDKGYAIGFEEMVAWINSQLPANEEIGMALRKDARMYPEISIRELAANMIIHQDFAVQGFPMIEIYSDRIEFSNPGQPLISVERFIDEYQSRNDTLADIMRRMGICEEKGSGMDKTIFYVELYQLPPVRFQLYESRTTATVFSYRKFADLDKSERVRACYQHACLKYVSNEKMNNQSLRTRLGIEDKNYPMASRIIKDALEAKLIKEENAEGGNRHNYIPYWA
>NC_014371.1|WP_013265383.1|1243698_1245807_+|DUF262-domain-containing-protein
MKGYAKPLYEFIEGNKIQFVIPVYQRNYDWLIDNCDQLLSDLVKLSRLNRYSHFFGSIVTSSADNNSYNRLVIDGQQRLTTISLLLLAGIKAVKDDAIEISDKKRVEEAYEVFLNAKFCNAERKIKLVPIENDRIAYDKIFNGEGSFNEESKITRNYHHFYEKLTRRPQLLSFDQLLDAIERLQIISIELDKDDDAQLIFESLNSTGLALTEADKIRNYLLMSLTPEEQLECFKNYWQKIELATESQPTRFLRDYLTIKQQLQRPVRLSNIYYEWKKYMEGHDRKEELIEMLDYAHYYQQVVEAKLFTAKLSEKMRHICNIETDVANVFFIQFLKYASTNELSEAEMYKVIDLVENYLARRIVCNMPGNALTQVFCALHKDVLKSLEEYASANIELDYSYSDILTFHIMRRDGNYQLPRDVQFVESIKTRDAYHMLKPFQIFLFERLENSVHGEYNDVAIDMKKKDATIEHIMPQTLSGEWKAMLGDNFEEIQEKYLHTFANLTLTGINSELSNKPFAIKRDGKAIGNEIYPGYRNSKYRLTKNVTLCEKWTETELQNRSNEIVTIFLRLYPLPQTTFKPLPKPVDEVSLEEESFTPTNRQLKGFRLFGNEYTETTWKEMLLRVVKMVEQQYTDIVDTLYDAEGFFWSAQQADTRYCTQIAPQKYLWTSMDNRSKLRCLRFLFEKCDIAESELVMLLEPIRE
>NC_014371.1|WP_013265710.1|1242123_1243680_+|type-I-restriction-modification-system-subunit-M
MSEELQQKLRDQLWEVANKLRGNMSASDFMYFTLGFIFYKYLSEKIEKHANDALVDDEVTFKELWSMEKDTDIEELQESVKTECIENIGYFIEPNFLFSSVIESIKKKENILPILERSLKRIEDSTLGQDSEEDFGGLFSDIDLASPKLGKTADDKNTLVSNVLLALDDIDFGVEASQEIDILGDAYEYMISQFAAGAGKKAGEFYTPQEVSRILAEIVTLGHARLRNVYDPTCGSGSLLLRAASIGHANEIFGQEKNPTTYNLARMNMLLHGIKFSNFRIENGDTLEADAFGDTQFDAVVANPPFSAEWSAADKFNNDDRFSKAGRLAPRKTADYAFILHMLYHLNEGGTMACVAPHGVLFRGNAEGVIRRFLIEKKNYVDAIIGLPANIFYGTSIPTCILVFKKCRKEDDSILFIDASKDFEKIKTQNKLRPQHIQKIVDTYRDRKEIEKYSHLATLEEIAENDYNLNIPRYVDTFEEEEPIDIHAVMKEIKDLEAKRADLDKEIEGYLKELGLVE
>NC_014371.1|WP_013265294.1|1241471_1242122_+|hypothetical-protein
MIKIIRGLDITALGVCVYNRKWQSVHLQQGDMDGACAVYSMMMNLIVLKVFTRNQVTNLNTSFKGNTAKGRLFKEFFVKEGLCRDGFYFSEIKEKLSHSFAKEVMSSARQYMISQSAQASYVEELKKGIDDNLPLVTAITFKGGAHAILAIGYEEEEGVIRKIFCLDPGHAISQTALWNSVIILNEGKGMYCHQYITDKDDENVFVSETLKIERKK
>NC_014371.1|WP_013265245.1|1238616_1241460_+|type-I-restriction-endonuclease-subunit-R
MPVQSEAALENGLIATLQQMNYEYVQIEEEKNLRTNFKSQLEKHNRKRLEEIGRTEFTEAEFEKILIYLEGGTRFEKAKKLRDLFPLELDNGERLWVEFLNRTHWCQNEFQVSHQITVEGRKKCRYDVTILINGLPLVQIELKRRGVELKQAYNQIQRYHKTSFHGLFDYVQLFVISNGVNTRYFANNPNSGYKFTFNWTDAANVPFNELEKFATSFFDKCTLGKIIGKYIVLHEGDKCLMVLRPYQFYAVEKILDRVKNSNNNGYIWHTTGAGKTLTSFKAAQLVAELDDVDKVMFVVDRHDLDTQTQSEYEAFEPGAVDSTDNTDELVKRLHGNSKIIITTIQKLNAAVSKQWYSRRIEEIRHARIVMIFDECHRSHFGDCHKNIVRFFDNTQIFGFTGTPIFVENAVDGHTTKEIFGNCLHKYLIKDAIADENVLGFLVEYYHGNADVDNANQNRMTEIAKFILNNFNKSTFDGEFDALFAVQSVSTLIRYYKIFKSLNPKIRIGAVFTYASNSSQDDALTGMNTGSYVSESTGEADELQAIMDDYNDMFGTSFTTENFRAYYDDINLRMKKKKTDMKPLDLCLVVGMFLTGFDSKKLNTLYVDKNMDYHGLLQAFSRTNRVLNEKKRFGKIVCFRDLKSNVDASIKLFSNSNNLEDIVRPPFNEVKKNYQELTTNFLEQYPTPSSIDLLQSEKDKKQFILAFRDVIKKHAEIQVYDEFEEDAADLGMTEQQFMDFRSKYLDIYDTFAGGCKPSEENQTPDEDTESTETSTESGIDDIDFCLELLHSDIINVTYILELIADLNPYSADYKEKRTYIIDTMIKDAELRNKAKLIDGFIQQNVDDDRDNFMARKQKFDGTSDLEERLNNYITTERNNAVDKLAKEEGLDVTVLNHYLSEYDYLQKEQPEIIQEALKEKHLGLIKKRKTLTRILDRLKSIIRTFSWE
>NC_014371.1|WP_044046142.1|1238357_1238576_+|helix-turn-helix-transcriptional-regulator
MINQQKKAIYRIKAVLAEKQLSGKWLANEIGRTENTVSRWCSNKVQPFLENLLEIAKALKVDVRDLLRSTEE
>NC_014371.1|WP_013265102.1|1237373_1237694_-|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MNITSEDEALIELYTNGKTSDKRYRSLPPQVTKGFKKAVDYMKAARRIEDLFPLKGLNYEALKGKRRGQESVRCNGAWRLIFRRSLIDESVIITNIELLEISHHYD
>NC_014371.1|WP_013265526.1|1253384_1255247_+|DUF4268-domain-containing-protein
MGLNNRLQIGDVSNNGQVEIVDEDRLCYLVRSTSKGATGLRTISKSLLEEYVNYWSEHSDATSESARQALSGTSEIDKYEYGYTSTLSVMAQMVLQSTHKVKNNVSSLPRQQIFYGAPGTGKSFTINQEIKGEDVIRTTFHPDSDYSSFVGAYKPTTREITMRDLSGHPVVEHGQTLTEEKIVYEFVPQAFLQAYIGAWEKYAACDEGNPHRQFLVIEEINRGNCAQIFGDLFQLLDRNHSGFSDYPVKADTDMKRYVAKALKGLTIPQAGAINSLYGGRDVVSEVLEGNILLLPSNLFIWATMNTSDQSLFPIDSAFKRRWDWSYMPISDAKKGYVIDVAGSQYDWWQFLEEINEKIENTTNSEDKKLGYFFCKAHGGVISAETFVGKVVFYLWNDVFKDFDLVGPIFDDTVEGGRLTFAKFYTEGEMKTKVRAEKVAQFLGNLGLTPLEESEEEYNGQAESTDDSENPRATWSVTERKRYDFWQAFLAYAQKNDEFKTYFGGTKKAGKDHWKNFYVSGADFYMSVVLKLWERAIALQVYFDRTTDTYYHLATQKKEIEAEMDTTYEWRENPEKKSSTIVERIDDIDFEDKEHWTTIFDLIITRTLRMREVFVKYSKQQ
>NC_014371.1|WP_013265709.1|1255256_1257431_+|LlaJI-restriction-endonuclease
MRILIEEYQYDVSKVRDILYGIDALENMEGRVSIHYVGYYYNTLLKDCVFILPKVLLKNVDGQDLVLGKYKPEDIANVDRYNSIDEVERSFIYKFAVWIYRAIVVYKNDKRSDTTIVCHSRIAQMGNGGRRLSNTYLDILLSLIQFNHDNQSFFFFVIKNLHSGLNKINWQRTIATKPAIIQDGQAVYLNPVNKRRQVNFDEELLVIFFSILNYIGDTYGFPKDICCQFPLITGKRFETYLKGLGKTRLRQIKYKYFSDKALRLWNLCYTFFKEARQISVSTEQREYLLVKNFNIVFEAIIDELIGDKEPPRGLKEQDDGKRVDHIYSYRNLTNNEEDRPIYYIGDSKYYKIGNKISDESVYKQFTYARNVIQWNLNLFLDNSEENAALRKEHPIYRDELTEGYNIVPNFFISAKMDEKLSYADNVSTTNRENNTFLSRHFENRLFDRDTLLVYHYDVNFLYVVSLYARENAHQKAQWKQKVRELFREKIQAALEENYKFYAMTPKPGVNHEEYLRENFQELLGKVYRPFDDTNYLSLALDKQKESENKDLLDKLQKDYYVVECPLGKNPTSVLSGEKAQNSSEAVHGRKGVLMVMMEKYATKSANFSHGKLAIAIKMTVESMDIVENLSNIGYVLFHHRSDNDQHLFSVKGTCTIKAAGELEDDRYKNMGNKELYISVDIDTTELPNDNLHASMIKPASKETRYDAQFAWLSDLESDNSKVAE
>NC_014371.1|WP_013265529.1|1257708_1258488_-|hypothetical-protein
MAKVNYPKGEKLARLLLDVLAKEPSYKEHSKGLPYYYISFEGQEYYLYFKCITHEGNPYPLEHRRSQLPQRPEFDKIKNDNIPFLFLGYDIDNDLFVCWEPAKVKPRLNNRSYVSFYSRLSIQESVEEGKIRDEYLTNGDKFVLFKRVDAVSFFQMIDTHFEELKHDDTQTDTRSVSEPPTDYNTQKKLGNHVQGRIVSVEEDVSIQLKIDSMAQNNSVLEIVADCMNEFSTYYPKMSFADWSQVIRKYLQNDNNLYKR
>NC_014371.1|WP_013265793.1|1258489_1259458_-|PD-(D/E)XK-motif-protein
MSNLYSTYSQLRERRKESGLYEVEDFIIGKPHKFGATEDGFPVIFVECCDDAVSTPIRLKAISVDFSQLCTLKDAGGETLTKKYTIIVLNSLEADLQSYFLEVFAMVLNKFSSTPSVSLLKAEISKVAKIFMMPPSFSAVVIQGLWAELFVIANAKSPEDLAKAWHVTAEDKYDFNDGKDKIEVKSTSNLDRVHTFALEQLNPNAGSELAIASVITVRSGQGVNVFDVLDTISQRGLSIEQMSKIQEIAYLTIGPHLEEAKKIKYDFTLALNSYMKFDYRDVPSIKSEHVPSGVTSVHFASCLKDVEPIDLSATNSGLLKFM
>NC_014371.1|WP_013265299.1|1259475_1261689_-|hypothetical-protein
MSSTIQVINPTNKQNNQVVIGNNTLHFMDSQSKLDDEGKSIIIDEAMKILSHCVKPGTNDSITNIAVGYVQSGKTLSFTTLTALAADNGYRMIIYLTGTKTNLEKQTSDRLASDLDTDSSDVYNLMSGIDDNFTLDTSIKNFLIHTDDVILIPILKHYKHIQRLADTFVSPTLKSCLNNLGVIIIDDEADQSSFNTFAKKNTANPDWIEDDFSKTYASILALKKSLPNHSYIQYTATPQAAFLIDNSDILSPTYHTVLTPGKGYTGGKFFFKNKNYQLVHLVDDAEVYHHKRNPLTTTPKSLIESLQQFLVSVAIVVFIQKRKNVDFLSMMIHVDGRCDTNTLFANWTKNALQQWIDILTLDEKDPGRKLVCKKFKNAYDEMTRYIQNPPSFDEVMKNMVKVILRTKIHLVQSQGGSVGDDGISWKSAKANILIGADMLNRGFTIEKLSMTYMTRTTQGKSNADTIEQRCRFFGYKMDYADICRIYLSKKSLVEYNDYVEHEETLRANLSQCETLEEFSKHSHAMLLAETLNPTRTNILSSKLVRNKLSGWKQMPSLDCIDNNKILFESFLSNIPSTAYTDCENYGNNPIRNHRWVNIPINDFIDFFKLVKYEDAPNITRKIVTIQYLYYLRDSVNVDHIRLYEMAYKATVQSGDIRTRSIKDDKPNNLQAGRAANGSYPGDIKFCTDNEVCVQVHHIKIKQPLHRLNSKDLYNLCIYYPENLATSFVGLDSDDEDD
>NC_014371.1|WP_013265452.1|1261701_1263267_-|ATP-binding-protein
MPSNVSIATRPLVYSTFRYISNKVWNALAEYIDNSIQSFLDHQDVLSKINPDGIKLRVSINMDFENDTIIIEDNAFGITEENYQRAFELANIPLDNKGLNEFGMGMKVSSIWLSNVWKVETTAYGDDVLKTVTFDLNEVVENEELSLPVTEESCDKEAHFTRITLSHLSGNKPTPRQLSYIKKHLASIYTLHLRKQTLELIVNDEPLEYKELTILNAPKYNEPNGKPILWKKDINLTFGERYAISGFIALLDTMSTSIDNGFLLFRRGRVIGSSYDERYRPKELCGQEGSPLYKRVFGELYLTGFDVSFTKNSFQEDDDFAELIKLLREDLNKDKTFDLFAQGQHYTKPRTQKEIKNIGTKLVKQIISGFTKPIVHTPSTTISTPNDTTPKKPALVIPVTTPQTQAKVEQIKSTPTDLFDGIPVDILLDNNEKVELTIKTGEAVAGLYTFNEIADDKYEATINLKNNVFQRFASSLSTQEGQEQLSYMIEVMVASEISMIKGGSDAATKFRSTFNNLFGTI
>NC_014371.1|WP_013265127.1|1263256_1264618_-|DNA-(cytosine-5-)-methyltransferase
MAKKKQLQFIDLFAGLGGFHLALSKLGCKCVFSSELKEDLRKLYQINYPGVRIEGDITKIAPKDIPAHDIICAGFPCQPFSQAGNRQGFNDEKGRGTLFDYIIDIVAYHKPKYIILENVSNLKGHDNGNTWRIIQEKLDEQEYSVKAEILSPHEFGIPQHRKRIYIVCIRKDLGLLDNFTFPKGNKPVCDVNDIIEANAKDITPIKEETHYQLNIWQEFIDKTIANGGTIPTFPIWAMEFGASYDFETVAPAFQSIEQLVEKKGKLGKIIRGTTLKECLAQLPNYSQTDKTRVFPVWKIRYIQQNRDFYNKHKSWLKGWMKKVVHFENSHLKMEWNCGVNVEPHIENKIVQFRASGIRVKKPTFVPALNLVGTQVPIFPWIELPKDMQKPEIGLTKGRYMTLHEAASVQGMRELSFGNDDFRLSLARSYEALGNAVNVELVKMIAKKLLDYAK
>NC_014371.1|WP_013265221.1|1264629_1264827_-|helix-turn-helix-transcriptional-regulator
MEDINQIKLALVKSKKTNKWLAEQLKVNPTTFSKWCTNTTQLNLYTLKKIAGLLNIPVSELIVSE
>NC_014371.1|WP_013265666.1|1266020_1266506_+|peptidase-M15
MINDSHSNEIDFEERLSPHFTVGEMMRSGKAVGMGIKNVPEENPAPGEASRAEVIENLRELCRCVLEPLRRRVGRVIVVGGYRCEAVNRAVHGAEHSQHLRGEAADIHVTGLEMCRKYAAILSQTDFDQMILEPQESIKKRWIHISYRRDGKNRHQILGAK
>NC_014371.1|WP_004359161.1|1267123_1267645_+|HU-family-DNA-binding-protein
MSIKFRMYQDNRKNSKRKGYWYARAVSPDLVSVKDLALRISERCTVTEPDILAVISALVFEMNQVLKDGNRVKLDGLGTFRVGIHSQGVQKAEDFNAQRDIYGAHVLFSPTVTIDAMKRRVKTLISGLRIQEAVQYDAPKAAEKAKNKGKKKENKPSAGPEPGEATATTEGHA

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Crispr_ID: NC_014371_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014371_8

1345065-1345166

Orphan

Consensus_repeat	Method
ACCTCCCCCGACCCCTCCAAAGGAGGGGAGTGCCTAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014371_8

>merge|NC_014371|8|1345065-1345166|CRISPRCasFinder
ACCTCCCCCGACCCCTCCAAAGGAGGGGAGTGCCTAACGGAGTGAGAGTTAAATCAAAAGCAGGAACCTCCCCCAACCCCTCCAAAGGAGGGGAGTGCCTAA

>NC_014371|8|8|1345065-1345166|CRISPRCasFinder
ACCTCCCCCGACCCCTCCAAAGGAGGGGAGTGCCTAA	CGGAGTGAGAGTTAAATCAAAAGCAGGA
ACCTCCCCCAACCCCTCCAAAGGAGGGGAGTGCCTAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_014371.1\|WP_013265871.1\|1359074_1359683_-\|recombination-protein-RecR	unknown	unknown	gnl\|CDD\|234616
NC_014371.1\|WP_013265466.1\|1340325_1341171_-\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_013265555.1\|1344490_1344760_+\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_013265662.1\|1353807_1355586_+\|M6-family-metalloprotease-domain-containing-protein	unknown	unknown	gnl\|CDD\|274507
NC_014371.1\|WP_013265323.1\|1341434_1343132_-\|energy-dependent-translational-throttle-protein-EttA	unknown	unknown	gnl\|CDD\|236992
NC_014371.1\|WP_013265074.1\|1351245_1352859_+\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	unknown	unknown	gnl\|CDD\|369630
NC_014371.1\|WP_013265061.1\|1358614_1359067_-\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_013265628.1\|1357411_1358614_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|224137
NC_014371.1\|WP_013265536.1\|1343401_1344220_-\|KilA-N-domain-containing-protein	unknown	unknown	gnl\|CDD\|367917
NC_014371.1\|WP_013265745.1\|1339088_1339859_-\|NYN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350289
NC_014371.1\|WP_108235558.1\|1326485_1326911_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NC_014371.1\|WP_044046158.1\|1345510_1345714_+\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_044046161.1\|1356889_1357408_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379112
NC_014371.1\|WP_013265577.1\|1329685_1330339_-\|rubrerythrin	unknown	unknown	gnl\|CDD\|153100
NC_014371.1\|WP_013265708.1\|1331138_1334933_+\|DUF5110-domain-containing-protein	unknown	unknown	gnl\|CDD\|269882
NC_014371.1\|WP_044046162.1\|1359866_1360361_-\|outer-membrane-beta-barrel-protein	unknown	unknown	unknown
NC_014371.1\|WP_044046156.1\|1326910_1327354_+\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_013265507.1\|1345741_1347448_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372499
NC_014371.1\|WP_044046157.1\|1335587_1338782_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379166
NC_014371.1\|WP_044046159.1\|1348103_1351223_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|274948

Protein	Function_ID	Function_description	E-value
NC_014371.1\|WP_013265871.1\|1359074_1359683_-\|recombination-protein-RecR	gnl\|CDD\|234616	PRK00076, recR, recombination protein RecR; Reviewed.	6.95636e-114
NC_014371.1\|WP_108235558.1\|1326485_1326911_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	3.68133e-09
NC_014371.1\|WP_013265662.1\|1353807_1355586_+\|M6-family-metalloprotease-domain-containing-protein	gnl\|CDD\|274507	TIGR03296, hypothetical_protein, M6 family metalloprotease domain. This model describes a metalloproteinase domain, with a characteristic HExxH motif. Examples of this domain are found in proteins in the family of immune inhibitor A, which cleaves antibacterial peptides, and in other, only distantly related proteases. This model is built to be broader and more inclusive than pfam05547.	2.71626e-55
NC_014371.1\|WP_013265323.1\|1341434_1343132_-\|energy-dependent-translational-throttle-protein-EttA	gnl\|CDD\|236992	PRK11819, PRK11819, putative ABC transporter ATP-binding protein; Reviewed.	0
NC_014371.1\|WP_013265074.1\|1351245_1352859_+\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	gnl\|CDD\|369630	pfam07980, SusD_RagB, SusD family. This domain is found in bacterial cell surface proteins such SusD and SusD-like proteins, as as well RagB, outer membrane surface receptor antigen. Bacteroidetes, one of the two dominant bacterial phyla in the human gut, are Gram-negative saccharolytic microorganisms that utilize a diverse array of glycans. Hence, they express starch-utilization system (Sus) for glycan uptake. SusD has 551 amino acids, and is almost entirely alpha-helical, with 22 alpha-helices, eight of which form 4 tetra-trico peptide repeats (TPRs: helix-turn-helix motifs involved in protein-protein interactions). The four TPRs pack together to create a right-handed super-helix. This is predicted to mediate the formation of SusD and SusC porin complex at the cell surface. The interaction between SusC and TPR1/TPR2 region of SusD is predicted to be of functional importance since it allows SusD to be in position for oligosaccharide capture from other Sus lipoproteins and delivery of these glycans to the SusC porin. The non-TPR containing portion of SusD is where starch binding occurs. The binding site is a shallow surface cavity located on top of TPR1. SusD homologs such as SusD-like proteins have a critical role in carbohydrate acquisition. Both SusD and its homologs, contain about 15-20 residues at the N-terminus that might be a flexible linker region, anchoring the protein to the membrane and the glycan-binding domain. Other homologs to SusD have been examined in Porphyromonas gingivalis such as RagB, an immunodominant outer-membrane surface receptor antigen. Structural characterization of RagB shows substantial similarity with Bacteroides thetaiotaomicron SusD (i.e alpha-helices and TPR regions). Based on this structural similarity, functional studies suggest that, RagB binding of glycans occurs at pockets on the molecular surface that are distinct from those of SusD.	3.91272e-58
NC_014371.1\|WP_013265628.1\|1357411_1358614_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|224137	COG1216, COG1216, Predicted glycosyltransferases [General function prediction only].	6.12833e-47
NC_014371.1\|WP_013265536.1\|1343401_1344220_-\|KilA-N-domain-containing-protein	gnl\|CDD\|367917	pfam04383, KilA-N, KilA-N domain. The amino-terminal module of the D6R/N1R proteins defines a novel, conserved DNA-binding domain (the KilA-N domain) that is found in a wide range of proteins of large bacterial and eukaryotic DNA viruses. The KilA-N domain family also includes the previously defined APSES domain. The KilA-N and APSES domains may also share a common fold with the nucleic acid-binding modules of the LAGLIDADG nucleases and the amino-terminal domains of the tRNA endonuclease.	2.07193e-11
NC_014371.1\|WP_013265745.1\|1339088_1339859_-\|NYN-domain-containing-protein	gnl\|CDD\|350289	cd18722, PIN_NicB-like, LabA-like PIN domain of Pseudomonas putida S16 NicB and related proteins. Curiously NicB from Pseudomonas putida S16 is described as a putative NADH-dependent hydroxylase involved in the microbial degradation of nicotine. This subfamily also includes the uncharacterized CPP15 (plasmid) protein from Campylobacter jejuni. This subfamily belongs to LabA-like PIN domain family which includes Synechococcus elongatus PCC 7942 LabA, human ZNF451, uncharacterized Bacillus subtilis YqxD and Escherichia coli YaiI, and the N-terminal domain of a well-conserved group of mainly bacterial proteins with no defined function, which contain a C-terminal LabA_like_C domain. Curiously, a gene labeled NicB from Pseudomonas putida S16, which is described as a putative NADH-dependent hydroxylase involved in the microbial degradation of nicotine also falls into the LabA-like PIN family. The PIN (PilT N terminus) domain belongs to a large nuclease superfamily. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	1.16447e-25
NC_014371.1\|WP_013265507.1\|1345741_1347448_+\|hypothetical-protein	gnl\|CDD\|372499	pfam13149, Mfa_like_1, Fimbrillin-like. A family of putative fimbrillin proteins found by clustering human gut metagenomic sequences. Analysis of structural comparisons shows this family to be part of the FimbA (CL0450) superfamily of adhesin components or fimbrillins.	2.05988e-05
NC_014371.1\|WP_044046161.1\|1356889_1357408_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	2.39499e-24
NC_014371.1\|WP_013265708.1\|1331138_1334933_+\|DUF5110-domain-containing-protein	gnl\|CDD\|269882	cd06596, GH31_CPE1046, Clostridium CPE1046-like. CPE1046 is an uncharacterized Clostridium perfringens protein with a glycosyl hydrolase family 31 (GH31) domain. The domain architecture of CPE1046 and its orthologs includes a C-terminal fibronectin type 3 (FN3) domain and a coagulation factor 5/8 type C domain in addition to the GH31 domain. Enzymes of the GH31 family possess a wide range of different hydrolytic activities including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase, 3-alpha-isomaltosyltransferase and alpha-1,4-glucan lyase. All GH31 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein.	0
NC_014371.1\|WP_013265577.1\|1329685_1330339_-\|rubrerythrin	gnl\|CDD\|153100	cd01041, Rubrerythrin, Rubrerythrin, ferritin-like diiron-binding domain. Rubrerythrin domain is a nonheme iron binding domain found in many air-sensitive bacteria and archaea and member of a broad superfamily of ferritin-like diiron-carboxylate proteins. The homodimeric rubrerythrin protein contains a binuclear metal center located within a four helix bundle. Many, but not all, rubrerythrin proteins have a second domain with a rubredoxin-like hexacoordinated iron center. Rubrerythrin is thought to reduce hydrogen peroxide as part of an oxidative stress protection system but its function is still poorly understood.	2.66247e-58
NC_014371.1\|WP_044046157.1\|1335587_1338782_+\|hypothetical-protein	gnl\|CDD\|379166	pfam13402, Peptidase_M60, Peptidase M60, enhancin and enhancin-like. This family of peptidases contains a zinc metallopeptidase motif (HEXXHX(8,28)E) and possesses mucinase activity. It includes the viral enhancins as well as enhancin-like peptidases from bacterial species. Enhancins are a class of metalloproteases found in some baculoviruses that enhance viral infection by degrading the peritrophic membrane (PM) of the insect midgut. Bacterial enhancins are found to be cytotoxic when compared to viral enhancin, however, suggesting that the bacterial enhancins do not enhance infection in the same way as viral enhancin. Bacterial enhancins may have evolved a distinct biochemical function. These bacterial domains are peptidases targetting host glycoproteins and thus probably play an important role in successful colonisation of both vertebrate mucosal surfaces and the invertebrate digestive tract by both mutualistic and pathogenic microbes. This family has been augmented by a merge with the sequences in the Enhancin Pfam family.	1.46764e-33
NC_014371.1\|WP_044046159.1\|1348103_1351223_+\|TonB-dependent-receptor	gnl\|CDD\|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0

>NC_014371.1|WP_013265555.1|1344490_1344760_+|hypothetical-protein
MEESPSAYRWFGYMFVWMLACLLILDKGVSSELFLFILLLVAIVLNAYCAYKFALGKGTFLAILAFVVAMVLDFFPIVAYFVIIEIFMA
>NC_014371.1|WP_013265536.1|1343401_1344220_-|KilA-N-domain-containing-protein
MTKKGEIFVKDVAIKTMTKDGIDYICITDIARQKNTAEPKDVVKNWMRQKNTLEYLGLWEKLNNPNFKGVEFDPLLAEAGSNSFTMSPTRWVELTAAIGVFTKNGAGGGTFAQRDIAFKFANWVSVEFELYLVMEFQRLKAKEQELIGWTAKRELSKINYRIHTDAIKSHLIPEKVTPTQANIIYAEEADVLNVAMFGMTARQWRESNPDLKGNIRDYASVNELICLANMENINAVLINDDIPQGERLVRLNQIAIHQMQILERNSNRNLLR
>NC_014371.1|WP_013265323.1|1341434_1343132_-|energy-dependent-translational-throttle-protein-EttA
MATVDDKKIIFSMVGVSKIIPQNQKQILKNIYLSFFYGAKIGIIGLNGAGKSTLMKIIAGLVEPTQGEVVWSPGYSVGYLPQDPPLDEAKTVKENVMEGVQHIYDALKEYDDINVKFGLEEYYSDADKMDKLMQRQAELQDIIDATDAWNIDSRLERAMDALRCPKGDLPVTNLSGGERRRVALCRLLLQKPDVLLLDEPTNHLDAESIDWLEQHLQQYEGTVIAVTHDRYFLDDVSEWILELDRGEGIPWKGNYSSWLDQKTKRMEQEEKSASKRRKTLERELEWVRMAPKARQAKGKARLNSYEQMLNEEQKQREEKLEIFIPNGPRLGNKVIEAQHVKKAFGEKVLFNDLNFMLPPNGIVGVIGPNGAGKTTLFRLIMGLEQADGGTFEVGETVKLAYVDQQHKDIDPNKTVYDVVSQGNETIRMGGRDINSRAYLSRFNFSGTDQSKLCSVLSGGERNRLQLAMALKQEGNVLLLDEPTNDIDVNTLRALEEGLEAFAGCAVVISHDRWFLDRICTHILAFEGNGEVVYFEGGFSDYEINKARRLGNEEIKKGRYRKLMEE
>NC_014371.1|WP_013265466.1|1340325_1341171_-|hypothetical-protein
MFVLFFLCFSIYGKAQTAPKKLTAPSPERFQAINDSILAEGMWLYTYEKLAWRATDSLMKYNVKREEINSATAFEEGNLTWRYIFANLDKEQTVFELTLHLSNDTSFYVCSATPRKLKPTEIEQLKAKQIAPRKVIKEKGDSIFLANTSGLNWDLLPLEKGGYRLYLLHGTTKHGVIPIGDDYAFDFDKDMNILSWRRFHRSFLEQPITMNGEEITEVIHSHTPMTPYFTTTDIANYMLYGCDLYGIKRFSVLSTAFADTSYLTTFDVEKMKLTSTVYTVK
>NC_014371.1|WP_013265745.1|1339088_1339859_-|NYN-domain-containing-protein
MEKKLGTYLLILYFCSIKSIALLSCRVSATSEWLFLFNLHTMPKRVTFYFDGFNFYFALKRKKKISPEWKDFYWLDLVAFCESFLGPDQVLEKVIYFTASPLSPQKNSRQSAFLNANRILHSDKFEVIRGKYMSKQIECPYCKYSISKPEEKRTDVNISVRMMADCVQDKTDVIVLISADTDLIPPLNFIHTNYPNKKVKVFFPPGSHALELHNHLRTFHSKWVFLEKNERRFRNAVMPHTITVGNQSVSIPEKWK
>NC_014371.1|WP_044046157.1|1335587_1338782_+|hypothetical-protein
MLFERFLRNKSLMAAMALTAVMPSVAKASILSAAPTAEGENQQLKAGVYFIVNDKRQAGTDLHVYVDESGLHGKNYTSLAADYSNAFLLHAKGDKYTIQSLKDGKYVQNVNGNSVPYKTGNDAHKFQIVYQSQSSGTGKSYFNIYNDNVGGNQFCWHLDAQRNVVRWYPLTDNGRIALGPSEFRLDPVTSLSKQQVLDRLAELTKIVDPRKDLNKYYQIVSDTYGRAMREDYIVGELSTGGFVDTDYSYCWKLVKLGSGRYAFQNAVTGKYIAQQNGQTSRYYTTSEEQGNGFEFNLNESDPYVLTFEMVDAYNVGIHCAESQGYHPVGWYVNNEANKWVFKVATIDQAKLKEQQDAYKARVDLTRNVDRYATAVAKYFTNSAATEVTAATKAMTDEALKAQMTTEGVPQGLQEVVLKIKNQSWTVYPSGRNWEKQFRIADYKVYSENNYGAWARSMGIGYDYGSMTNPTGVTARDGEDLFVFLGDDIPQDATVQIELVPLGTRSAGKYHNLKKGLNIILNQGENNVFVNYIGRTFNNGKYLRDYKPMNIHIEGGKVNGYFDLTKGNTNEDWQKMQSDGLVWAKAFNMKGELVVMNMPSQACKDYTPVHMKELVEIWNSIVQREDDLMGFRAAKRDKCNNVLNATAVDHGYMYATTGGTYYNYNTLADVLNYDKMKWGNGTLWGPAHEFGHNHQQLFNTAGMTEISVNMYSNMVMFTSGRVTSRSEHCNYTDVDGQEHRGVCESAVSTYADRFANKKMWFEYGTWGTTQMYYKLYMMFHSTGLDDQFWHKCLDYLRTHRLEGQGTANCQGQNDYLLFAKACCVAANQDLSSFFEAWGHFYDVNGSVIGDYSNTTMYTTRAQWVEAKKFMQQFPKGPANNMIFIDDHIRPTPAIYPGAAPGTMREDFNGAVRVGTMGDFGSWDQFCPDSLGQGYAIIKTQSDANGRRTYTMEAKNSHVVGFKIYDSKGNLIYFANTKTFTIPKKVMEDAQNNIVIKVCGSDGSEVDPGTVPLGIKTFSAQANGGKVDVYSIYGVLVRSKVNPETALEGLPNGVYVVGGKKVVVGK
>NC_014371.1|WP_013265708.1|1331138_1334933_+|DUF5110-domain-containing-protein
MKKKKAKILLAALLLAVGETAFADGKAVSGIRQINPTTVEITYSDGGVMTVDFYGQNVFRLFRDPKGGIVRDPVSNPPARILLDNPRKNAGRLSVNATDADVAVATAEVRVRFDRNTGLMTVTDLRNGKEVIKEVKGVDFQKNRTTVTLANAAGEYFYGGGVQNGRFSHRGKRIEIVNTNSWTDGGVASPAPFYWSTGGYAAMPYTFAPGAYDFGSTDKNTVTISHDMPYLDLFLMVDTTPVSLLQDYYQLTGNPVLLPKFAFYEGHLNAYNRDYWKETTEEGKGILFEDGKRYVESQKDNGGIKESLNGEKQNYQFSARAVIDRYKKDDMPLGWILPNDGYGAGYGQTTTLDGNIANLKSLGDYARKNGVEIGLWTQSNLHPVDSIPALLQRDIVKEVRDAGVRVLKTDVAWVGAGYSFGLNGIADVANIMPYYGSDARPFIITLDGWAGTQRYGGVWSGDQTGGEWEYIRFHIPTYIGSGLSGMGNITSDMDGIFGGKNLPVNIRDFQWKTFTPMQLNMDGWGSNPKYPQALGEPATSINRSYLKLKSILLPYTYSCAHEAVTGKPLMRAMFLDDSNDYTHSSATRYQYMYGPSFLVAPVYQNTAADKEGNDVRNGIYLPKGTWYDYFTGATYEGGCILNDYFAPIWKLPVLVKSGAIIPMVNPNNNPSEIDKNRRVFELYPDGKTEFTLYDDDGTTQKYLANEKATTRITSDLNDKQVLTVSIDKTEGSFDGMVKNQSTTFYLNTNAKPKKLTAVIGGKKIRLTEAEQGDNTWQYVQASNINRFSTANSEMERLLVTKNAQIIVRLSSCDITKEAVELRVEGFVRLNKSNETLRKKGALTAPELLEADIQSYSVTPKWKPVQNADYYEIAFNGQTYTTIRHNSLLFDDLQPATDYDFKVRAVNSEGASEWTPLHVKTAVNPLEYAIQGLTATSTARDMEGFEIHRLVDFSTTGDIWHTYYYTKAVPFDFTVDLHSTNTLDKLQYVPRANGGNGTITKCDIAVSKDGRNWTEIGPQQWARDGRTKEVTLSTHPVARYVKVSVKEAVGNFGSGREFYVFKVPGTKTILPGDINLDGKVDENDFTSYMNYTGLKKGDADFDGYISGGDINGNGLIDAYDISNVAMHLEDGWNDDDVAPVGGKVYYEYNRKSYAAGDDVIIKVKGKDLQSVNAFNLIFPYSPKELQFVKVETDPSMVMRNLTYDRHHSDGSQVLYPTFVNVGDHHTINGDADLLVIRMKALKPFTVKNTTAKGLLVDKQLREVEL
>NC_014371.1|WP_013265577.1|1329685_1330339_-|rubrerythrin
MKKKFICTVCGYIHEGTEAPAECPVCHAKAAKFKEFNPEALKGTKTEQNLKNAFAGESQAHTKYLYYASKAKKDGYEQIAGFFEETARNEKEHAKIWFKFLHEGDIPTTTQNLADAAAGENYEWTDMYEQMAKDAMEEGFPELAVKFRSVGKVEKHHEERYRKLLKNIEDSVVFSREGDCIWQCRNCGHIVIGKKAPAVCPVCNHPQSFFQVEESNY
>NC_014371.1|WP_044046156.1|1326910_1327354_+|hypothetical-protein
MKNGDKIEFAIVGMQEDSYKVNYDIDFSKLNQEELEFQIEQRINVSAEPENIIISMRVHLMNGAEEIAMQGVRAIFKVKPFNSFVNDMQEDDLKVSNPALIDTFISVCIGAIRGMLVKNLKGTPLDNVVLPLIPMNVIRANSTKRTK
>NC_014371.1|WP_108235558.1|1326485_1326911_+|helix-turn-helix-transcriptional-regulator
MKCMSKMQVKKNVLSQLLSTIDEVALKKTSNRMMIAAKIGNALKDKGISQKEFAKKLKKSESEVSSWLSGDRNFTIDTLTEISLALDISLLDTEVQSVYSFPTRIFLPETGNVSNTKISVSSQWTCSLGYIDCRNKTQKVG
>NC_014371.1|WP_044046158.1|1345510_1345714_+|hypothetical-protein
MKKSYVKPCSTCVIMAVEQAMLAGSKGLRVTNQNLERVDHTIIGSSTPSTPSAGGNAKENPFQYDEE
>NC_014371.1|WP_013265507.1|1345741_1347448_+|hypothetical-protein
MNFKKIYGLILGVIVAGLTSCSSDLNNEEKAPVGPNETAVRSLSIATGDAKTRSEVKIDADNKWVTGDRFMAFNRTFTGSSSESRYGVLTASSTGTRTTLDGVIACKDNDELGIFYPGSYVTGFDQGKMPVVMTASYINDNKGQDGSKENLKYFDYSYGKGKVTVNGASASGSVDMKKLYSVLELDFTAGGVKLTNIKKLVLSNVLTEAVYNIQSNQLESLETGKIEVNSPVALEKVYVAILPQNHFSPTFEVYTTDNKSYRFAVSTPNFNLVAAKVYPFTVQVKEFTPNPPYIEIGGVKWGKYNLQYSTGTKVNGWVDGYHLAENPWDYYMYTPSKITEPLSDLQMSLPSYNPNDVKFDHFRWGDIEYAYDYTKTGQFWTERRDIQGVISSDKKHGDLAAYASNNKWKLPSATDFNNLMKATAEYLGYFIDDNGNKVYGVLFDPNVAEGLKGKVLDKNNKVLGSSNTAAIINAGKNLRQFVKSDFDNALFFPMAGIYYTYTGAIDKPGSQGGYWTSTSNPSNNNAAAFMPQMMSNSLGVYQGFSGTTQKALINKNNMHSIRPIYVGQ
>NC_014371.1|WP_044046159.1|1348103_1351223_+|TonB-dependent-receptor
MSNFMKVSQSRRKHPPFVSGRLAFSFALGLMAFAPSPVLANVDANTSMSVQQQKQSINGVVKDANGDPVIGASILANGTPVGVTDMDGRFSVSVAPGTELKISYVGFATQSVMVRSGVTNYNITLKDENSALSEVVVVGYGTQKKANLSGSVAQLDSKALENRPISNVSSGLQGLLPGITVTGADGAPGLDNGSILVRGVGTLNSASPYILIDGVEAGTLNSLDPEDIASISVLKDASSAAIYGSKASNGVILVTTKRGQNGAPKVSYSGYFGIQNATALMERMNSADAAYYYNKALERSGKAARFSDEAIKKFRDGSDPYNYPNTDWYDLAFKTAWQNRHSVNITGGNEYVKYLASAGYLKQSSILPNAGREQFNGRANLDMVLSKRITAHLNLAYIQNNYRDASSAYAGGSSDQIIRQLNIIAPWIVYKYEDGTYGTVSDGNPMAWLESGMTVNRNNRNFTGMIGLDYQILKDLKLTLQGAYVDASQRYSYFQKFIQYNPNKASDPNKLEIAHYDWHRTTFDAFLNYDKSFAKHNFKAMLGWHTERYKYLPDWMYRKNFPNNELTDMNAGDASTQQNAGNTRELSMVSYFGRLNYDYAGRYLFEANFRSDASSRFAEAHRWGFFPSFSAAWRISEEPFMESSKSWLNNLKLRASWGQLGNQDALNDYYPWMNTYNLNAKYPFGGQLTPGYYQGSYHLETISWERSTTWGVGLDFTLFGGLTGSLDYYNRKTTGIIMNVSAPAEFALGAYKDNIGALRNQGVELSLAYAKQLNKDWTINVGANFAYNKNKILNLGEGTEYIGSGNRRTAVGQQYNSFFMYKATGKFFNSQQEADDYTAKYGNPFGRKFMAGDLIYEDTNGDDKLDSNDRIYTKHTDIPAITYGFNLGATWKNIDLSMIWQGVGAVSHIYNREVLGEFSGDASHPSTLWKDSWTDDNHNAKLPRVFETGNSPSDMTRAMSTFWLWNTAYLRLKTLQLGYTLPKSALKAIGLEKVRIYYAGENLLTFDALPFNIDPEVTSERGSSYPLLRSHSIGINITF
>NC_014371.1|WP_013265074.1|1351245_1352859_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein
MKTVRTYILAGVAAFALTSCNDYLTTVPKDAMSPSTTWKTGDDAEKFLVGCYDGWEDGGALLYWDAGSDFAYNNFPWEGFTNIGNGSLSPSSPGWSFYDYTIIGRCNTFLENVDKCVFSSDAVKKDLVAQVKAIRAYNYFRMGFLYGGVPIVKPFTSAQEARVPRNTEQEVKDLVFKDLDEAIADINTSPAARGRIAKGAALAMKMRAALYWGDYQKAKDAAQAIIDLGKYELDPDYTNLFKLAGVDSKEIILAVQYKSGTRPLGTIGQLYNNGDGGWSSVVPTQKCVDNYEMSNGMTITEAGSGYDATHPFHGRDPRMAMTILYPGCDWEGTIFNTLDENVNGKKNPNYPTNAANSSKTALTWRKYLDPKTQYADVWDTEACPIVFRYAEVLLTWAEAENELNGPSANVYAMIDKVRTRVGMPAVDQSKYNTKDKLRELIRRERGSEFAGEGLRRADILRWTSNGKMVAETVLNGPLNRITGTINTSATDPTMRAVVSGSSKVEDRTFQTFNRYLPIPQWNISDNPKLEQNPGYAK
>NC_014371.1|WP_013265662.1|1353807_1355586_+|M6-family-metalloprotease-domain-containing-protein
MKKIITLLVSVLLATSSFAIPAMRMWRSFKQADGTILKVMTVGDEHFNYALTEDNIPVLPHNGSYYYARIEDNQLVPSSVLAHDKALRKGKEELVAAAIQQVRQLQKQHEMHVNSKPFGEGLGMTWEGKKKGLVILVEFEDVAFKDPKNVLTLKPREKDVKTLYENMLNKVGYTNDNGAIGSVHDYFLDQSNGKFDLTFDVVGPVKLKHPHQFYGERTANMNDANAPQMIIDACNAIQGQVDFSKYDWDDDGEVEQVYVIYAGEGEATGGESSTIWPHKYSLTDAGLDALTFNGQTINTYACSNEIIRAKVNEKSRIYYSGIGTICHEFSHCLGLPDFYDTRGGSNIGSGRYDLMCGGSYNGGPESLINVYGGTGIGTVPAGYDAYEKAYMGWLKPITLGDEAVEVKNMKGLAEGGDAYFLYNPDTKNEYYIFENRTPHRWDAELPGHGLMVFHVDFDAYSWRMNNLNAASAQRHPRFTIVSADGRLDHDTQNSDPFPTDLNNSLTKSTDPRLSFYTNYNVSSQAGVKQIVRNNDNTISFHFTPLKAATGINNLSADHEQLAETYTLSGVKVADNQNLHNQIVIVKGKKVRK
>NC_014371.1|WP_044046161.1|1356889_1357408_-|GNAT-family-N-acetyltransferase
MEKKQYVEVRLRAMEPEDLDMLYHIENDRSLWNISATNVPYSRYALHNYIADAKNDIYIDGQLRMMIENREQEIVGVIDLVNFDPKHQRAEMGIIIMKPFRQKGYAKAAISALIDYTRNGLHLKQIYAVVDVDNEVSIRCLSSIGFTNGSILKEWLYCDGQYKDARVMQLFI
>NC_014371.1|WP_013265628.1|1357411_1358614_-|glycosyltransferase-family-2-protein
MKLSVVIVNYNVKYYLQQCLESLQRALKGVEAEVFVVDNHSHDGSVAYLRSRFPDVHFIASAHNLGFAGGNNIAIRQSKGEYVLLLNPDTVVGEEVIHASIDFMDSHLTAGGHGVQMLTHCGERALESRRGLPSPMVSFYKMVGLCKHFPQSGRFAHYYMGSLSWDVPGKIEVISGAYCFLRRTALDKVGLLDEDFFMYGEDVDLSYRLLKGGFENWYLPVRILHYKGESTQKSSFRYVHVFYDAMLIFFRKHYGGMNVLWRLPIKTAIYVKAFGSLIGTTIRATRKKLGFRTSKAKSFPHYIFVAGEDVMGKCQRLATDNALVAEYRVADKDSLQHMHADLLKEFGGKSRAYCIVYDTDLFSYQDILNVFAEQPKQNIHIGFYHRKENRVVTMMEVIGD
>NC_014371.1|WP_013265061.1|1358614_1359067_-|hypothetical-protein
MDKTRKILLIEFFGSCLITLLIIAVYELELILPGAWADVESSNMVTVQFLMQLLTLATIPLALFLFKIGYVHSDLHTDESHVSRKLLFWGSVRIMMLCVPMILNTFFYYAFGDSVSFFYLAVILALSLFFVFPNKKRCEHECSMDNSEQA
>NC_014371.1|WP_013265871.1|1359074_1359683_-|recombination-protein-RecR
MQQYPSQLLERAVEAFSQLPGVGRKTALRLVLHLLRQSTEDVDSFADAVIRVKHDVKYCKVCHNISDNEVCSICSDPRRDASVVCVVENIQDVMAIENTQQFHGLYHVLGGIISPMDGIGPHDLEIESLVERVEEGTVKEIILALASTMEGDTTNFYISRKLKDTGVKLSVIARGISVGDELEYTDEVTLGRSILNRTPFES
>NC_014371.1|WP_044046162.1|1359866_1360361_-|outer-membrane-beta-barrel-protein
MIKRFMLLVAAMVVSISASAQFQEGKGYLGASLTGLDLHYNGHDGMNIGVQAKAGYFPWDNLMVLATFDAVHNGSEAVADHISVGVGGRYYITQNGLYLGAGVKLLHANHNYNDLMPGVEVGYAFFINRSVTIEPALYYDQSFKTHNYSTVGLKVGLGIYLFDD

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Crispr_ID: NC_014371_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014371_9

1347768-1347850

Orphan

Consensus_repeat	Method
ACTCCCCTCCCTATGGGGGAGGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014371_9

>merge|NC_014371|9|1347768-1347850|CRISPRCasFinder
ACTCCCCTCCCTATGGGGGAGGGGACGGGGGGTGGGGCCAGTTGCTTTTGTTACATTTTACTCCCCTCCCTATGGGGGAGGGG

>NC_014371|9|9|1347768-1347850|CRISPRCasFinder
ACTCCCCTCCCTATGGGGGAGGGG	ACGGGGGGTGGGGCCAGTTGCTTTTGTTACATTTT
ACTCCCCTCCCTATGGGGGAGGGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_014371.1\|WP_013265871.1\|1359074_1359683_-\|recombination-protein-RecR	unknown	unknown	gnl\|CDD\|234616
NC_014371.1\|WP_013265507.1\|1345741_1347448_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372499
NC_014371.1\|WP_013265555.1\|1344490_1344760_+\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_013265662.1\|1353807_1355586_+\|M6-family-metalloprotease-domain-containing-protein	unknown	unknown	gnl\|CDD\|274507
NC_014371.1\|WP_013265323.1\|1341434_1343132_-\|energy-dependent-translational-throttle-protein-EttA	unknown	unknown	gnl\|CDD\|236992
NC_014371.1\|WP_013265074.1\|1351245_1352859_+\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	unknown	unknown	gnl\|CDD\|369630
NC_014371.1\|WP_013265061.1\|1358614_1359067_-\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_013265628.1\|1357411_1358614_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|224137
NC_014371.1\|WP_013265536.1\|1343401_1344220_-\|KilA-N-domain-containing-protein	unknown	unknown	gnl\|CDD\|367917
NC_014371.1\|WP_013265745.1\|1339088_1339859_-\|NYN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350289
NC_014371.1\|WP_013265466.1\|1340325_1341171_-\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_044046158.1\|1345510_1345714_+\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_044046161.1\|1356889_1357408_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379112
NC_014371.1\|WP_044046236.1\|1361074_1361281_-\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_013265708.1\|1331138_1334933_+\|DUF5110-domain-containing-protein	unknown	unknown	gnl\|CDD\|269882
NC_014371.1\|WP_044046162.1\|1359866_1360361_-\|outer-membrane-beta-barrel-protein	unknown	unknown	unknown
NC_014371.1\|WP_013265577.1\|1329685_1330339_-\|rubrerythrin	unknown	unknown	gnl\|CDD\|153100
NC_014371.1\|WP_044046157.1\|1335587_1338782_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379166
NC_014371.1\|WP_044046159.1\|1348103_1351223_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|274948
NC_014371.1\|WP_013265679.1\|1360761_1361019_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_014371.1\|WP_013265871.1\|1359074_1359683_-\|recombination-protein-RecR	gnl\|CDD\|234616	PRK00076, recR, recombination protein RecR; Reviewed.	6.95636e-114
NC_014371.1\|WP_013265507.1\|1345741_1347448_+\|hypothetical-protein	gnl\|CDD\|372499	pfam13149, Mfa_like_1, Fimbrillin-like. A family of putative fimbrillin proteins found by clustering human gut metagenomic sequences. Analysis of structural comparisons shows this family to be part of the FimbA (CL0450) superfamily of adhesin components or fimbrillins.	2.05988e-05
NC_014371.1\|WP_013265662.1\|1353807_1355586_+\|M6-family-metalloprotease-domain-containing-protein	gnl\|CDD\|274507	TIGR03296, hypothetical_protein, M6 family metalloprotease domain. This model describes a metalloproteinase domain, with a characteristic HExxH motif. Examples of this domain are found in proteins in the family of immune inhibitor A, which cleaves antibacterial peptides, and in other, only distantly related proteases. This model is built to be broader and more inclusive than pfam05547.	2.71626e-55
NC_014371.1\|WP_013265323.1\|1341434_1343132_-\|energy-dependent-translational-throttle-protein-EttA	gnl\|CDD\|236992	PRK11819, PRK11819, putative ABC transporter ATP-binding protein; Reviewed.	0
NC_014371.1\|WP_013265074.1\|1351245_1352859_+\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	gnl\|CDD\|369630	pfam07980, SusD_RagB, SusD family. This domain is found in bacterial cell surface proteins such SusD and SusD-like proteins, as as well RagB, outer membrane surface receptor antigen. Bacteroidetes, one of the two dominant bacterial phyla in the human gut, are Gram-negative saccharolytic microorganisms that utilize a diverse array of glycans. Hence, they express starch-utilization system (Sus) for glycan uptake. SusD has 551 amino acids, and is almost entirely alpha-helical, with 22 alpha-helices, eight of which form 4 tetra-trico peptide repeats (TPRs: helix-turn-helix motifs involved in protein-protein interactions). The four TPRs pack together to create a right-handed super-helix. This is predicted to mediate the formation of SusD and SusC porin complex at the cell surface. The interaction between SusC and TPR1/TPR2 region of SusD is predicted to be of functional importance since it allows SusD to be in position for oligosaccharide capture from other Sus lipoproteins and delivery of these glycans to the SusC porin. The non-TPR containing portion of SusD is where starch binding occurs. The binding site is a shallow surface cavity located on top of TPR1. SusD homologs such as SusD-like proteins have a critical role in carbohydrate acquisition. Both SusD and its homologs, contain about 15-20 residues at the N-terminus that might be a flexible linker region, anchoring the protein to the membrane and the glycan-binding domain. Other homologs to SusD have been examined in Porphyromonas gingivalis such as RagB, an immunodominant outer-membrane surface receptor antigen. Structural characterization of RagB shows substantial similarity with Bacteroides thetaiotaomicron SusD (i.e alpha-helices and TPR regions). Based on this structural similarity, functional studies suggest that, RagB binding of glycans occurs at pockets on the molecular surface that are distinct from those of SusD.	3.91272e-58
NC_014371.1\|WP_013265628.1\|1357411_1358614_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|224137	COG1216, COG1216, Predicted glycosyltransferases [General function prediction only].	6.12833e-47
NC_014371.1\|WP_013265536.1\|1343401_1344220_-\|KilA-N-domain-containing-protein	gnl\|CDD\|367917	pfam04383, KilA-N, KilA-N domain. The amino-terminal module of the D6R/N1R proteins defines a novel, conserved DNA-binding domain (the KilA-N domain) that is found in a wide range of proteins of large bacterial and eukaryotic DNA viruses. The KilA-N domain family also includes the previously defined APSES domain. The KilA-N and APSES domains may also share a common fold with the nucleic acid-binding modules of the LAGLIDADG nucleases and the amino-terminal domains of the tRNA endonuclease.	2.07193e-11
NC_014371.1\|WP_013265745.1\|1339088_1339859_-\|NYN-domain-containing-protein	gnl\|CDD\|350289	cd18722, PIN_NicB-like, LabA-like PIN domain of Pseudomonas putida S16 NicB and related proteins. Curiously NicB from Pseudomonas putida S16 is described as a putative NADH-dependent hydroxylase involved in the microbial degradation of nicotine. This subfamily also includes the uncharacterized CPP15 (plasmid) protein from Campylobacter jejuni. This subfamily belongs to LabA-like PIN domain family which includes Synechococcus elongatus PCC 7942 LabA, human ZNF451, uncharacterized Bacillus subtilis YqxD and Escherichia coli YaiI, and the N-terminal domain of a well-conserved group of mainly bacterial proteins with no defined function, which contain a C-terminal LabA_like_C domain. Curiously, a gene labeled NicB from Pseudomonas putida S16, which is described as a putative NADH-dependent hydroxylase involved in the microbial degradation of nicotine also falls into the LabA-like PIN family. The PIN (PilT N terminus) domain belongs to a large nuclease superfamily. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	1.16447e-25
NC_014371.1\|WP_044046161.1\|1356889_1357408_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	2.39499e-24
NC_014371.1\|WP_013265708.1\|1331138_1334933_+\|DUF5110-domain-containing-protein	gnl\|CDD\|269882	cd06596, GH31_CPE1046, Clostridium CPE1046-like. CPE1046 is an uncharacterized Clostridium perfringens protein with a glycosyl hydrolase family 31 (GH31) domain. The domain architecture of CPE1046 and its orthologs includes a C-terminal fibronectin type 3 (FN3) domain and a coagulation factor 5/8 type C domain in addition to the GH31 domain. Enzymes of the GH31 family possess a wide range of different hydrolytic activities including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase, 3-alpha-isomaltosyltransferase and alpha-1,4-glucan lyase. All GH31 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein.	0
NC_014371.1\|WP_013265577.1\|1329685_1330339_-\|rubrerythrin	gnl\|CDD\|153100	cd01041, Rubrerythrin, Rubrerythrin, ferritin-like diiron-binding domain. Rubrerythrin domain is a nonheme iron binding domain found in many air-sensitive bacteria and archaea and member of a broad superfamily of ferritin-like diiron-carboxylate proteins. The homodimeric rubrerythrin protein contains a binuclear metal center located within a four helix bundle. Many, but not all, rubrerythrin proteins have a second domain with a rubredoxin-like hexacoordinated iron center. Rubrerythrin is thought to reduce hydrogen peroxide as part of an oxidative stress protection system but its function is still poorly understood.	2.66247e-58
NC_014371.1\|WP_044046157.1\|1335587_1338782_+\|hypothetical-protein	gnl\|CDD\|379166	pfam13402, Peptidase_M60, Peptidase M60, enhancin and enhancin-like. This family of peptidases contains a zinc metallopeptidase motif (HEXXHX(8,28)E) and possesses mucinase activity. It includes the viral enhancins as well as enhancin-like peptidases from bacterial species. Enhancins are a class of metalloproteases found in some baculoviruses that enhance viral infection by degrading the peritrophic membrane (PM) of the insect midgut. Bacterial enhancins are found to be cytotoxic when compared to viral enhancin, however, suggesting that the bacterial enhancins do not enhance infection in the same way as viral enhancin. Bacterial enhancins may have evolved a distinct biochemical function. These bacterial domains are peptidases targetting host glycoproteins and thus probably play an important role in successful colonisation of both vertebrate mucosal surfaces and the invertebrate digestive tract by both mutualistic and pathogenic microbes. This family has been augmented by a merge with the sequences in the Enhancin Pfam family.	1.46764e-33
NC_014371.1\|WP_044046159.1\|1348103_1351223_+\|TonB-dependent-receptor	gnl\|CDD\|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0

>NC_014371.1|WP_013265507.1|1345741_1347448_+|hypothetical-protein
MNFKKIYGLILGVIVAGLTSCSSDLNNEEKAPVGPNETAVRSLSIATGDAKTRSEVKIDADNKWVTGDRFMAFNRTFTGSSSESRYGVLTASSTGTRTTLDGVIACKDNDELGIFYPGSYVTGFDQGKMPVVMTASYINDNKGQDGSKENLKYFDYSYGKGKVTVNGASASGSVDMKKLYSVLELDFTAGGVKLTNIKKLVLSNVLTEAVYNIQSNQLESLETGKIEVNSPVALEKVYVAILPQNHFSPTFEVYTTDNKSYRFAVSTPNFNLVAAKVYPFTVQVKEFTPNPPYIEIGGVKWGKYNLQYSTGTKVNGWVDGYHLAENPWDYYMYTPSKITEPLSDLQMSLPSYNPNDVKFDHFRWGDIEYAYDYTKTGQFWTERRDIQGVISSDKKHGDLAAYASNNKWKLPSATDFNNLMKATAEYLGYFIDDNGNKVYGVLFDPNVAEGLKGKVLDKNNKVLGSSNTAAIINAGKNLRQFVKSDFDNALFFPMAGIYYTYTGAIDKPGSQGGYWTSTSNPSNNNAAAFMPQMMSNSLGVYQGFSGTTQKALINKNNMHSIRPIYVGQ
>NC_014371.1|WP_044046158.1|1345510_1345714_+|hypothetical-protein
MKKSYVKPCSTCVIMAVEQAMLAGSKGLRVTNQNLERVDHTIIGSSTPSTPSAGGNAKENPFQYDEE
>NC_014371.1|WP_013265555.1|1344490_1344760_+|hypothetical-protein
MEESPSAYRWFGYMFVWMLACLLILDKGVSSELFLFILLLVAIVLNAYCAYKFALGKGTFLAILAFVVAMVLDFFPIVAYFVIIEIFMA
>NC_014371.1|WP_013265536.1|1343401_1344220_-|KilA-N-domain-containing-protein
MTKKGEIFVKDVAIKTMTKDGIDYICITDIARQKNTAEPKDVVKNWMRQKNTLEYLGLWEKLNNPNFKGVEFDPLLAEAGSNSFTMSPTRWVELTAAIGVFTKNGAGGGTFAQRDIAFKFANWVSVEFELYLVMEFQRLKAKEQELIGWTAKRELSKINYRIHTDAIKSHLIPEKVTPTQANIIYAEEADVLNVAMFGMTARQWRESNPDLKGNIRDYASVNELICLANMENINAVLINDDIPQGERLVRLNQIAIHQMQILERNSNRNLLR
>NC_014371.1|WP_013265323.1|1341434_1343132_-|energy-dependent-translational-throttle-protein-EttA
MATVDDKKIIFSMVGVSKIIPQNQKQILKNIYLSFFYGAKIGIIGLNGAGKSTLMKIIAGLVEPTQGEVVWSPGYSVGYLPQDPPLDEAKTVKENVMEGVQHIYDALKEYDDINVKFGLEEYYSDADKMDKLMQRQAELQDIIDATDAWNIDSRLERAMDALRCPKGDLPVTNLSGGERRRVALCRLLLQKPDVLLLDEPTNHLDAESIDWLEQHLQQYEGTVIAVTHDRYFLDDVSEWILELDRGEGIPWKGNYSSWLDQKTKRMEQEEKSASKRRKTLERELEWVRMAPKARQAKGKARLNSYEQMLNEEQKQREEKLEIFIPNGPRLGNKVIEAQHVKKAFGEKVLFNDLNFMLPPNGIVGVIGPNGAGKTTLFRLIMGLEQADGGTFEVGETVKLAYVDQQHKDIDPNKTVYDVVSQGNETIRMGGRDINSRAYLSRFNFSGTDQSKLCSVLSGGERNRLQLAMALKQEGNVLLLDEPTNDIDVNTLRALEEGLEAFAGCAVVISHDRWFLDRICTHILAFEGNGEVVYFEGGFSDYEINKARRLGNEEIKKGRYRKLMEE
>NC_014371.1|WP_013265466.1|1340325_1341171_-|hypothetical-protein
MFVLFFLCFSIYGKAQTAPKKLTAPSPERFQAINDSILAEGMWLYTYEKLAWRATDSLMKYNVKREEINSATAFEEGNLTWRYIFANLDKEQTVFELTLHLSNDTSFYVCSATPRKLKPTEIEQLKAKQIAPRKVIKEKGDSIFLANTSGLNWDLLPLEKGGYRLYLLHGTTKHGVIPIGDDYAFDFDKDMNILSWRRFHRSFLEQPITMNGEEITEVIHSHTPMTPYFTTTDIANYMLYGCDLYGIKRFSVLSTAFADTSYLTTFDVEKMKLTSTVYTVK
>NC_014371.1|WP_013265745.1|1339088_1339859_-|NYN-domain-containing-protein
MEKKLGTYLLILYFCSIKSIALLSCRVSATSEWLFLFNLHTMPKRVTFYFDGFNFYFALKRKKKISPEWKDFYWLDLVAFCESFLGPDQVLEKVIYFTASPLSPQKNSRQSAFLNANRILHSDKFEVIRGKYMSKQIECPYCKYSISKPEEKRTDVNISVRMMADCVQDKTDVIVLISADTDLIPPLNFIHTNYPNKKVKVFFPPGSHALELHNHLRTFHSKWVFLEKNERRFRNAVMPHTITVGNQSVSIPEKWK
>NC_014371.1|WP_044046157.1|1335587_1338782_+|hypothetical-protein
MLFERFLRNKSLMAAMALTAVMPSVAKASILSAAPTAEGENQQLKAGVYFIVNDKRQAGTDLHVYVDESGLHGKNYTSLAADYSNAFLLHAKGDKYTIQSLKDGKYVQNVNGNSVPYKTGNDAHKFQIVYQSQSSGTGKSYFNIYNDNVGGNQFCWHLDAQRNVVRWYPLTDNGRIALGPSEFRLDPVTSLSKQQVLDRLAELTKIVDPRKDLNKYYQIVSDTYGRAMREDYIVGELSTGGFVDTDYSYCWKLVKLGSGRYAFQNAVTGKYIAQQNGQTSRYYTTSEEQGNGFEFNLNESDPYVLTFEMVDAYNVGIHCAESQGYHPVGWYVNNEANKWVFKVATIDQAKLKEQQDAYKARVDLTRNVDRYATAVAKYFTNSAATEVTAATKAMTDEALKAQMTTEGVPQGLQEVVLKIKNQSWTVYPSGRNWEKQFRIADYKVYSENNYGAWARSMGIGYDYGSMTNPTGVTARDGEDLFVFLGDDIPQDATVQIELVPLGTRSAGKYHNLKKGLNIILNQGENNVFVNYIGRTFNNGKYLRDYKPMNIHIEGGKVNGYFDLTKGNTNEDWQKMQSDGLVWAKAFNMKGELVVMNMPSQACKDYTPVHMKELVEIWNSIVQREDDLMGFRAAKRDKCNNVLNATAVDHGYMYATTGGTYYNYNTLADVLNYDKMKWGNGTLWGPAHEFGHNHQQLFNTAGMTEISVNMYSNMVMFTSGRVTSRSEHCNYTDVDGQEHRGVCESAVSTYADRFANKKMWFEYGTWGTTQMYYKLYMMFHSTGLDDQFWHKCLDYLRTHRLEGQGTANCQGQNDYLLFAKACCVAANQDLSSFFEAWGHFYDVNGSVIGDYSNTTMYTTRAQWVEAKKFMQQFPKGPANNMIFIDDHIRPTPAIYPGAAPGTMREDFNGAVRVGTMGDFGSWDQFCPDSLGQGYAIIKTQSDANGRRTYTMEAKNSHVVGFKIYDSKGNLIYFANTKTFTIPKKVMEDAQNNIVIKVCGSDGSEVDPGTVPLGIKTFSAQANGGKVDVYSIYGVLVRSKVNPETALEGLPNGVYVVGGKKVVVGK
>NC_014371.1|WP_013265708.1|1331138_1334933_+|DUF5110-domain-containing-protein
MKKKKAKILLAALLLAVGETAFADGKAVSGIRQINPTTVEITYSDGGVMTVDFYGQNVFRLFRDPKGGIVRDPVSNPPARILLDNPRKNAGRLSVNATDADVAVATAEVRVRFDRNTGLMTVTDLRNGKEVIKEVKGVDFQKNRTTVTLANAAGEYFYGGGVQNGRFSHRGKRIEIVNTNSWTDGGVASPAPFYWSTGGYAAMPYTFAPGAYDFGSTDKNTVTISHDMPYLDLFLMVDTTPVSLLQDYYQLTGNPVLLPKFAFYEGHLNAYNRDYWKETTEEGKGILFEDGKRYVESQKDNGGIKESLNGEKQNYQFSARAVIDRYKKDDMPLGWILPNDGYGAGYGQTTTLDGNIANLKSLGDYARKNGVEIGLWTQSNLHPVDSIPALLQRDIVKEVRDAGVRVLKTDVAWVGAGYSFGLNGIADVANIMPYYGSDARPFIITLDGWAGTQRYGGVWSGDQTGGEWEYIRFHIPTYIGSGLSGMGNITSDMDGIFGGKNLPVNIRDFQWKTFTPMQLNMDGWGSNPKYPQALGEPATSINRSYLKLKSILLPYTYSCAHEAVTGKPLMRAMFLDDSNDYTHSSATRYQYMYGPSFLVAPVYQNTAADKEGNDVRNGIYLPKGTWYDYFTGATYEGGCILNDYFAPIWKLPVLVKSGAIIPMVNPNNNPSEIDKNRRVFELYPDGKTEFTLYDDDGTTQKYLANEKATTRITSDLNDKQVLTVSIDKTEGSFDGMVKNQSTTFYLNTNAKPKKLTAVIGGKKIRLTEAEQGDNTWQYVQASNINRFSTANSEMERLLVTKNAQIIVRLSSCDITKEAVELRVEGFVRLNKSNETLRKKGALTAPELLEADIQSYSVTPKWKPVQNADYYEIAFNGQTYTTIRHNSLLFDDLQPATDYDFKVRAVNSEGASEWTPLHVKTAVNPLEYAIQGLTATSTARDMEGFEIHRLVDFSTTGDIWHTYYYTKAVPFDFTVDLHSTNTLDKLQYVPRANGGNGTITKCDIAVSKDGRNWTEIGPQQWARDGRTKEVTLSTHPVARYVKVSVKEAVGNFGSGREFYVFKVPGTKTILPGDINLDGKVDENDFTSYMNYTGLKKGDADFDGYISGGDINGNGLIDAYDISNVAMHLEDGWNDDDVAPVGGKVYYEYNRKSYAAGDDVIIKVKGKDLQSVNAFNLIFPYSPKELQFVKVETDPSMVMRNLTYDRHHSDGSQVLYPTFVNVGDHHTINGDADLLVIRMKALKPFTVKNTTAKGLLVDKQLREVEL
>NC_014371.1|WP_013265577.1|1329685_1330339_-|rubrerythrin
MKKKFICTVCGYIHEGTEAPAECPVCHAKAAKFKEFNPEALKGTKTEQNLKNAFAGESQAHTKYLYYASKAKKDGYEQIAGFFEETARNEKEHAKIWFKFLHEGDIPTTTQNLADAAAGENYEWTDMYEQMAKDAMEEGFPELAVKFRSVGKVEKHHEERYRKLLKNIEDSVVFSREGDCIWQCRNCGHIVIGKKAPAVCPVCNHPQSFFQVEESNY
>NC_014371.1|WP_044046159.1|1348103_1351223_+|TonB-dependent-receptor
MSNFMKVSQSRRKHPPFVSGRLAFSFALGLMAFAPSPVLANVDANTSMSVQQQKQSINGVVKDANGDPVIGASILANGTPVGVTDMDGRFSVSVAPGTELKISYVGFATQSVMVRSGVTNYNITLKDENSALSEVVVVGYGTQKKANLSGSVAQLDSKALENRPISNVSSGLQGLLPGITVTGADGAPGLDNGSILVRGVGTLNSASPYILIDGVEAGTLNSLDPEDIASISVLKDASSAAIYGSKASNGVILVTTKRGQNGAPKVSYSGYFGIQNATALMERMNSADAAYYYNKALERSGKAARFSDEAIKKFRDGSDPYNYPNTDWYDLAFKTAWQNRHSVNITGGNEYVKYLASAGYLKQSSILPNAGREQFNGRANLDMVLSKRITAHLNLAYIQNNYRDASSAYAGGSSDQIIRQLNIIAPWIVYKYEDGTYGTVSDGNPMAWLESGMTVNRNNRNFTGMIGLDYQILKDLKLTLQGAYVDASQRYSYFQKFIQYNPNKASDPNKLEIAHYDWHRTTFDAFLNYDKSFAKHNFKAMLGWHTERYKYLPDWMYRKNFPNNELTDMNAGDASTQQNAGNTRELSMVSYFGRLNYDYAGRYLFEANFRSDASSRFAEAHRWGFFPSFSAAWRISEEPFMESSKSWLNNLKLRASWGQLGNQDALNDYYPWMNTYNLNAKYPFGGQLTPGYYQGSYHLETISWERSTTWGVGLDFTLFGGLTGSLDYYNRKTTGIIMNVSAPAEFALGAYKDNIGALRNQGVELSLAYAKQLNKDWTINVGANFAYNKNKILNLGEGTEYIGSGNRRTAVGQQYNSFFMYKATGKFFNSQQEADDYTAKYGNPFGRKFMAGDLIYEDTNGDDKLDSNDRIYTKHTDIPAITYGFNLGATWKNIDLSMIWQGVGAVSHIYNREVLGEFSGDASHPSTLWKDSWTDDNHNAKLPRVFETGNSPSDMTRAMSTFWLWNTAYLRLKTLQLGYTLPKSALKAIGLEKVRIYYAGENLLTFDALPFNIDPEVTSERGSSYPLLRSHSIGINITF
>NC_014371.1|WP_013265074.1|1351245_1352859_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein
MKTVRTYILAGVAAFALTSCNDYLTTVPKDAMSPSTTWKTGDDAEKFLVGCYDGWEDGGALLYWDAGSDFAYNNFPWEGFTNIGNGSLSPSSPGWSFYDYTIIGRCNTFLENVDKCVFSSDAVKKDLVAQVKAIRAYNYFRMGFLYGGVPIVKPFTSAQEARVPRNTEQEVKDLVFKDLDEAIADINTSPAARGRIAKGAALAMKMRAALYWGDYQKAKDAAQAIIDLGKYELDPDYTNLFKLAGVDSKEIILAVQYKSGTRPLGTIGQLYNNGDGGWSSVVPTQKCVDNYEMSNGMTITEAGSGYDATHPFHGRDPRMAMTILYPGCDWEGTIFNTLDENVNGKKNPNYPTNAANSSKTALTWRKYLDPKTQYADVWDTEACPIVFRYAEVLLTWAEAENELNGPSANVYAMIDKVRTRVGMPAVDQSKYNTKDKLRELIRRERGSEFAGEGLRRADILRWTSNGKMVAETVLNGPLNRITGTINTSATDPTMRAVVSGSSKVEDRTFQTFNRYLPIPQWNISDNPKLEQNPGYAK
>NC_014371.1|WP_013265662.1|1353807_1355586_+|M6-family-metalloprotease-domain-containing-protein
MKKIITLLVSVLLATSSFAIPAMRMWRSFKQADGTILKVMTVGDEHFNYALTEDNIPVLPHNGSYYYARIEDNQLVPSSVLAHDKALRKGKEELVAAAIQQVRQLQKQHEMHVNSKPFGEGLGMTWEGKKKGLVILVEFEDVAFKDPKNVLTLKPREKDVKTLYENMLNKVGYTNDNGAIGSVHDYFLDQSNGKFDLTFDVVGPVKLKHPHQFYGERTANMNDANAPQMIIDACNAIQGQVDFSKYDWDDDGEVEQVYVIYAGEGEATGGESSTIWPHKYSLTDAGLDALTFNGQTINTYACSNEIIRAKVNEKSRIYYSGIGTICHEFSHCLGLPDFYDTRGGSNIGSGRYDLMCGGSYNGGPESLINVYGGTGIGTVPAGYDAYEKAYMGWLKPITLGDEAVEVKNMKGLAEGGDAYFLYNPDTKNEYYIFENRTPHRWDAELPGHGLMVFHVDFDAYSWRMNNLNAASAQRHPRFTIVSADGRLDHDTQNSDPFPTDLNNSLTKSTDPRLSFYTNYNVSSQAGVKQIVRNNDNTISFHFTPLKAATGINNLSADHEQLAETYTLSGVKVADNQNLHNQIVIVKGKKVRK
>NC_014371.1|WP_044046161.1|1356889_1357408_-|GNAT-family-N-acetyltransferase
MEKKQYVEVRLRAMEPEDLDMLYHIENDRSLWNISATNVPYSRYALHNYIADAKNDIYIDGQLRMMIENREQEIVGVIDLVNFDPKHQRAEMGIIIMKPFRQKGYAKAAISALIDYTRNGLHLKQIYAVVDVDNEVSIRCLSSIGFTNGSILKEWLYCDGQYKDARVMQLFI
>NC_014371.1|WP_013265628.1|1357411_1358614_-|glycosyltransferase-family-2-protein
MKLSVVIVNYNVKYYLQQCLESLQRALKGVEAEVFVVDNHSHDGSVAYLRSRFPDVHFIASAHNLGFAGGNNIAIRQSKGEYVLLLNPDTVVGEEVIHASIDFMDSHLTAGGHGVQMLTHCGERALESRRGLPSPMVSFYKMVGLCKHFPQSGRFAHYYMGSLSWDVPGKIEVISGAYCFLRRTALDKVGLLDEDFFMYGEDVDLSYRLLKGGFENWYLPVRILHYKGESTQKSSFRYVHVFYDAMLIFFRKHYGGMNVLWRLPIKTAIYVKAFGSLIGTTIRATRKKLGFRTSKAKSFPHYIFVAGEDVMGKCQRLATDNALVAEYRVADKDSLQHMHADLLKEFGGKSRAYCIVYDTDLFSYQDILNVFAEQPKQNIHIGFYHRKENRVVTMMEVIGD
>NC_014371.1|WP_013265061.1|1358614_1359067_-|hypothetical-protein
MDKTRKILLIEFFGSCLITLLIIAVYELELILPGAWADVESSNMVTVQFLMQLLTLATIPLALFLFKIGYVHSDLHTDESHVSRKLLFWGSVRIMMLCVPMILNTFFYYAFGDSVSFFYLAVILALSLFFVFPNKKRCEHECSMDNSEQA
>NC_014371.1|WP_013265871.1|1359074_1359683_-|recombination-protein-RecR
MQQYPSQLLERAVEAFSQLPGVGRKTALRLVLHLLRQSTEDVDSFADAVIRVKHDVKYCKVCHNISDNEVCSICSDPRRDASVVCVVENIQDVMAIENTQQFHGLYHVLGGIISPMDGIGPHDLEIESLVERVEEGTVKEIILALASTMEGDTTNFYISRKLKDTGVKLSVIARGISVGDELEYTDEVTLGRSILNRTPFES
>NC_014371.1|WP_044046162.1|1359866_1360361_-|outer-membrane-beta-barrel-protein
MIKRFMLLVAAMVVSISASAQFQEGKGYLGASLTGLDLHYNGHDGMNIGVQAKAGYFPWDNLMVLATFDAVHNGSEAVADHISVGVGGRYYITQNGLYLGAGVKLLHANHNYNDLMPGVEVGYAFFINRSVTIEPALYYDQSFKTHNYSTVGLKVGLGIYLFDD
>NC_014371.1|WP_013265679.1|1360761_1361019_-|hypothetical-protein
MKRIKIIRVLATFICHDPFAYSPIWTWDGFPPIIYTERERILPVLKEWEHKGYLTLIYDEKIAFILNVEKLPSKEKLIEESRNIK
>NC_014371.1|WP_044046236.1|1361074_1361281_-|hypothetical-protein
MSPIVDWNLLDVLNKNIRDNYERIRPILLKWQENGYIKLIEDNEIAFSFIPEKLPSKEKLIEESLNFK

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Crispr_ID: NC_014371_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014371_10

1353303-1353425

Orphan

Consensus_repeat	Method
GAGTGAACGAGTGGACAAGTGAACAAGTTACTTGCAAGAGAAGACAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014371_10

>merge|NC_014371|10|1353303-1353425|CRISPRCasFinder
GAGTGAACGAGTGGACAAGTGAACAAGTTACTTGCAAGAGAAGACAAAGTAACAGATGAACAGGTGTTTAGTGGACGAGTGAACGAGTGGTCAAGTGAACAAGTTACTTGCAAGAGAAGACAA

>NC_014371|10|10|1353303-1353425|CRISPRCasFinder
GAGTGAACGAGTGGACAAGTGAACAAGTTACTTGCAAGAGAAGACAA	AGTAACAGATGAACAGGTGTTTAGTGGAC
GAGTGAACGAGTGGTCAAGTGAACAAGTTACTTGCAAGAGAAGACAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_014371.1\|WP_013265871.1\|1359074_1359683_-\|recombination-protein-RecR	unknown	unknown	gnl\|CDD\|234616
NC_014371.1\|WP_013265507.1\|1345741_1347448_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372499
NC_014371.1\|WP_013265555.1\|1344490_1344760_+\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_013265662.1\|1353807_1355586_+\|M6-family-metalloprotease-domain-containing-protein	unknown	unknown	gnl\|CDD\|274507
NC_014371.1\|WP_013265323.1\|1341434_1343132_-\|energy-dependent-translational-throttle-protein-EttA	unknown	unknown	gnl\|CDD\|236992
NC_014371.1\|WP_013265074.1\|1351245_1352859_+\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	unknown	unknown	gnl\|CDD\|369630
NC_014371.1\|WP_013265061.1\|1358614_1359067_-\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_013265628.1\|1357411_1358614_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|224137
NC_014371.1\|WP_013265536.1\|1343401_1344220_-\|KilA-N-domain-containing-protein	unknown	unknown	gnl\|CDD\|367917
NC_014371.1\|WP_013265745.1\|1339088_1339859_-\|NYN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350289
NC_014371.1\|WP_013265466.1\|1340325_1341171_-\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_044046158.1\|1345510_1345714_+\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_044046161.1\|1356889_1357408_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379112
NC_014371.1\|WP_044046236.1\|1361074_1361281_-\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_044046162.1\|1359866_1360361_-\|outer-membrane-beta-barrel-protein	unknown	unknown	unknown
NC_014371.1\|WP_013265359.1\|1365368_1366100_-\|nitroreductase-family-protein	unknown	unknown	gnl\|CDD\|380322
NC_014371.1\|WP_044046157.1\|1335587_1338782_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379166
NC_014371.1\|WP_044046159.1\|1348103_1351223_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|274948
NC_014371.1\|WP_013265679.1\|1360761_1361019_-\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_013265392.1\|1362479_1364687_-\|sodium-translocating-pyrophosphatase	unknown	unknown	gnl\|CDD\|376979

Protein	Function_ID	Function_description	E-value
NC_014371.1\|WP_013265871.1\|1359074_1359683_-\|recombination-protein-RecR	gnl\|CDD\|234616	PRK00076, recR, recombination protein RecR; Reviewed.	6.95636e-114
NC_014371.1\|WP_013265507.1\|1345741_1347448_+\|hypothetical-protein	gnl\|CDD\|372499	pfam13149, Mfa_like_1, Fimbrillin-like. A family of putative fimbrillin proteins found by clustering human gut metagenomic sequences. Analysis of structural comparisons shows this family to be part of the FimbA (CL0450) superfamily of adhesin components or fimbrillins.	2.05988e-05
NC_014371.1\|WP_013265359.1\|1365368_1366100_-\|nitroreductase-family-protein	gnl\|CDD\|380322	cd02146, NfsA-like, nitroreductase similar to Escherichia coli NfsA. This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as an electron donor. Oxygen-insensitive nitroreductase, such as NfsA protein in Escherichia coli, catalyzes reduction of nitrocompounds using NADPH as electron donor.	3.3976e-74
NC_014371.1\|WP_013265662.1\|1353807_1355586_+\|M6-family-metalloprotease-domain-containing-protein	gnl\|CDD\|274507	TIGR03296, hypothetical_protein, M6 family metalloprotease domain. This model describes a metalloproteinase domain, with a characteristic HExxH motif. Examples of this domain are found in proteins in the family of immune inhibitor A, which cleaves antibacterial peptides, and in other, only distantly related proteases. This model is built to be broader and more inclusive than pfam05547.	2.71626e-55
NC_014371.1\|WP_013265323.1\|1341434_1343132_-\|energy-dependent-translational-throttle-protein-EttA	gnl\|CDD\|236992	PRK11819, PRK11819, putative ABC transporter ATP-binding protein; Reviewed.	0
NC_014371.1\|WP_013265074.1\|1351245_1352859_+\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	gnl\|CDD\|369630	pfam07980, SusD_RagB, SusD family. This domain is found in bacterial cell surface proteins such SusD and SusD-like proteins, as as well RagB, outer membrane surface receptor antigen. Bacteroidetes, one of the two dominant bacterial phyla in the human gut, are Gram-negative saccharolytic microorganisms that utilize a diverse array of glycans. Hence, they express starch-utilization system (Sus) for glycan uptake. SusD has 551 amino acids, and is almost entirely alpha-helical, with 22 alpha-helices, eight of which form 4 tetra-trico peptide repeats (TPRs: helix-turn-helix motifs involved in protein-protein interactions). The four TPRs pack together to create a right-handed super-helix. This is predicted to mediate the formation of SusD and SusC porin complex at the cell surface. The interaction between SusC and TPR1/TPR2 region of SusD is predicted to be of functional importance since it allows SusD to be in position for oligosaccharide capture from other Sus lipoproteins and delivery of these glycans to the SusC porin. The non-TPR containing portion of SusD is where starch binding occurs. The binding site is a shallow surface cavity located on top of TPR1. SusD homologs such as SusD-like proteins have a critical role in carbohydrate acquisition. Both SusD and its homologs, contain about 15-20 residues at the N-terminus that might be a flexible linker region, anchoring the protein to the membrane and the glycan-binding domain. Other homologs to SusD have been examined in Porphyromonas gingivalis such as RagB, an immunodominant outer-membrane surface receptor antigen. Structural characterization of RagB shows substantial similarity with Bacteroides thetaiotaomicron SusD (i.e alpha-helices and TPR regions). Based on this structural similarity, functional studies suggest that, RagB binding of glycans occurs at pockets on the molecular surface that are distinct from those of SusD.	3.91272e-58
NC_014371.1\|WP_013265628.1\|1357411_1358614_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|224137	COG1216, COG1216, Predicted glycosyltransferases [General function prediction only].	6.12833e-47
NC_014371.1\|WP_013265536.1\|1343401_1344220_-\|KilA-N-domain-containing-protein	gnl\|CDD\|367917	pfam04383, KilA-N, KilA-N domain. The amino-terminal module of the D6R/N1R proteins defines a novel, conserved DNA-binding domain (the KilA-N domain) that is found in a wide range of proteins of large bacterial and eukaryotic DNA viruses. The KilA-N domain family also includes the previously defined APSES domain. The KilA-N and APSES domains may also share a common fold with the nucleic acid-binding modules of the LAGLIDADG nucleases and the amino-terminal domains of the tRNA endonuclease.	2.07193e-11
NC_014371.1\|WP_013265745.1\|1339088_1339859_-\|NYN-domain-containing-protein	gnl\|CDD\|350289	cd18722, PIN_NicB-like, LabA-like PIN domain of Pseudomonas putida S16 NicB and related proteins. Curiously NicB from Pseudomonas putida S16 is described as a putative NADH-dependent hydroxylase involved in the microbial degradation of nicotine. This subfamily also includes the uncharacterized CPP15 (plasmid) protein from Campylobacter jejuni. This subfamily belongs to LabA-like PIN domain family which includes Synechococcus elongatus PCC 7942 LabA, human ZNF451, uncharacterized Bacillus subtilis YqxD and Escherichia coli YaiI, and the N-terminal domain of a well-conserved group of mainly bacterial proteins with no defined function, which contain a C-terminal LabA_like_C domain. Curiously, a gene labeled NicB from Pseudomonas putida S16, which is described as a putative NADH-dependent hydroxylase involved in the microbial degradation of nicotine also falls into the LabA-like PIN family. The PIN (PilT N terminus) domain belongs to a large nuclease superfamily. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	1.16447e-25
NC_014371.1\|WP_044046161.1\|1356889_1357408_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	2.39499e-24
NC_014371.1\|WP_044046157.1\|1335587_1338782_+\|hypothetical-protein	gnl\|CDD\|379166	pfam13402, Peptidase_M60, Peptidase M60, enhancin and enhancin-like. This family of peptidases contains a zinc metallopeptidase motif (HEXXHX(8,28)E) and possesses mucinase activity. It includes the viral enhancins as well as enhancin-like peptidases from bacterial species. Enhancins are a class of metalloproteases found in some baculoviruses that enhance viral infection by degrading the peritrophic membrane (PM) of the insect midgut. Bacterial enhancins are found to be cytotoxic when compared to viral enhancin, however, suggesting that the bacterial enhancins do not enhance infection in the same way as viral enhancin. Bacterial enhancins may have evolved a distinct biochemical function. These bacterial domains are peptidases targetting host glycoproteins and thus probably play an important role in successful colonisation of both vertebrate mucosal surfaces and the invertebrate digestive tract by both mutualistic and pathogenic microbes. This family has been augmented by a merge with the sequences in the Enhancin Pfam family.	1.46764e-33
NC_014371.1\|WP_044046159.1\|1348103_1351223_+\|TonB-dependent-receptor	gnl\|CDD\|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
NC_014371.1\|WP_013265392.1\|1362479_1364687_-\|sodium-translocating-pyrophosphatase	gnl\|CDD\|376979	pfam03030, H_PPase, Inorganic H+ pyrophosphatase. The H+ pyrophosphatase is an transmembrane proton pump involved in establishing the H+ electrochemical potential difference between the vacuole lumen and the cell cytosol. Vacuolar-type H(+)-translocating inorganic pyrophosphatases have long been considered to be restricted to plants and to a few species of photo-trophic bacteria. However, in recent investigations, these pyrophosphatases have been found in organisms as disparate as thermophilic Archaea and parasitic protists.	0

>NC_014371.1|WP_013265074.1|1351245_1352859_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein
MKTVRTYILAGVAAFALTSCNDYLTTVPKDAMSPSTTWKTGDDAEKFLVGCYDGWEDGGALLYWDAGSDFAYNNFPWEGFTNIGNGSLSPSSPGWSFYDYTIIGRCNTFLENVDKCVFSSDAVKKDLVAQVKAIRAYNYFRMGFLYGGVPIVKPFTSAQEARVPRNTEQEVKDLVFKDLDEAIADINTSPAARGRIAKGAALAMKMRAALYWGDYQKAKDAAQAIIDLGKYELDPDYTNLFKLAGVDSKEIILAVQYKSGTRPLGTIGQLYNNGDGGWSSVVPTQKCVDNYEMSNGMTITEAGSGYDATHPFHGRDPRMAMTILYPGCDWEGTIFNTLDENVNGKKNPNYPTNAANSSKTALTWRKYLDPKTQYADVWDTEACPIVFRYAEVLLTWAEAENELNGPSANVYAMIDKVRTRVGMPAVDQSKYNTKDKLRELIRRERGSEFAGEGLRRADILRWTSNGKMVAETVLNGPLNRITGTINTSATDPTMRAVVSGSSKVEDRTFQTFNRYLPIPQWNISDNPKLEQNPGYAK
>NC_014371.1|WP_044046159.1|1348103_1351223_+|TonB-dependent-receptor
MSNFMKVSQSRRKHPPFVSGRLAFSFALGLMAFAPSPVLANVDANTSMSVQQQKQSINGVVKDANGDPVIGASILANGTPVGVTDMDGRFSVSVAPGTELKISYVGFATQSVMVRSGVTNYNITLKDENSALSEVVVVGYGTQKKANLSGSVAQLDSKALENRPISNVSSGLQGLLPGITVTGADGAPGLDNGSILVRGVGTLNSASPYILIDGVEAGTLNSLDPEDIASISVLKDASSAAIYGSKASNGVILVTTKRGQNGAPKVSYSGYFGIQNATALMERMNSADAAYYYNKALERSGKAARFSDEAIKKFRDGSDPYNYPNTDWYDLAFKTAWQNRHSVNITGGNEYVKYLASAGYLKQSSILPNAGREQFNGRANLDMVLSKRITAHLNLAYIQNNYRDASSAYAGGSSDQIIRQLNIIAPWIVYKYEDGTYGTVSDGNPMAWLESGMTVNRNNRNFTGMIGLDYQILKDLKLTLQGAYVDASQRYSYFQKFIQYNPNKASDPNKLEIAHYDWHRTTFDAFLNYDKSFAKHNFKAMLGWHTERYKYLPDWMYRKNFPNNELTDMNAGDASTQQNAGNTRELSMVSYFGRLNYDYAGRYLFEANFRSDASSRFAEAHRWGFFPSFSAAWRISEEPFMESSKSWLNNLKLRASWGQLGNQDALNDYYPWMNTYNLNAKYPFGGQLTPGYYQGSYHLETISWERSTTWGVGLDFTLFGGLTGSLDYYNRKTTGIIMNVSAPAEFALGAYKDNIGALRNQGVELSLAYAKQLNKDWTINVGANFAYNKNKILNLGEGTEYIGSGNRRTAVGQQYNSFFMYKATGKFFNSQQEADDYTAKYGNPFGRKFMAGDLIYEDTNGDDKLDSNDRIYTKHTDIPAITYGFNLGATWKNIDLSMIWQGVGAVSHIYNREVLGEFSGDASHPSTLWKDSWTDDNHNAKLPRVFETGNSPSDMTRAMSTFWLWNTAYLRLKTLQLGYTLPKSALKAIGLEKVRIYYAGENLLTFDALPFNIDPEVTSERGSSYPLLRSHSIGINITF
>NC_014371.1|WP_013265507.1|1345741_1347448_+|hypothetical-protein
MNFKKIYGLILGVIVAGLTSCSSDLNNEEKAPVGPNETAVRSLSIATGDAKTRSEVKIDADNKWVTGDRFMAFNRTFTGSSSESRYGVLTASSTGTRTTLDGVIACKDNDELGIFYPGSYVTGFDQGKMPVVMTASYINDNKGQDGSKENLKYFDYSYGKGKVTVNGASASGSVDMKKLYSVLELDFTAGGVKLTNIKKLVLSNVLTEAVYNIQSNQLESLETGKIEVNSPVALEKVYVAILPQNHFSPTFEVYTTDNKSYRFAVSTPNFNLVAAKVYPFTVQVKEFTPNPPYIEIGGVKWGKYNLQYSTGTKVNGWVDGYHLAENPWDYYMYTPSKITEPLSDLQMSLPSYNPNDVKFDHFRWGDIEYAYDYTKTGQFWTERRDIQGVISSDKKHGDLAAYASNNKWKLPSATDFNNLMKATAEYLGYFIDDNGNKVYGVLFDPNVAEGLKGKVLDKNNKVLGSSNTAAIINAGKNLRQFVKSDFDNALFFPMAGIYYTYTGAIDKPGSQGGYWTSTSNPSNNNAAAFMPQMMSNSLGVYQGFSGTTQKALINKNNMHSIRPIYVGQ
>NC_014371.1|WP_044046158.1|1345510_1345714_+|hypothetical-protein
MKKSYVKPCSTCVIMAVEQAMLAGSKGLRVTNQNLERVDHTIIGSSTPSTPSAGGNAKENPFQYDEE
>NC_014371.1|WP_013265555.1|1344490_1344760_+|hypothetical-protein
MEESPSAYRWFGYMFVWMLACLLILDKGVSSELFLFILLLVAIVLNAYCAYKFALGKGTFLAILAFVVAMVLDFFPIVAYFVIIEIFMA
>NC_014371.1|WP_013265536.1|1343401_1344220_-|KilA-N-domain-containing-protein
MTKKGEIFVKDVAIKTMTKDGIDYICITDIARQKNTAEPKDVVKNWMRQKNTLEYLGLWEKLNNPNFKGVEFDPLLAEAGSNSFTMSPTRWVELTAAIGVFTKNGAGGGTFAQRDIAFKFANWVSVEFELYLVMEFQRLKAKEQELIGWTAKRELSKINYRIHTDAIKSHLIPEKVTPTQANIIYAEEADVLNVAMFGMTARQWRESNPDLKGNIRDYASVNELICLANMENINAVLINDDIPQGERLVRLNQIAIHQMQILERNSNRNLLR
>NC_014371.1|WP_013265323.1|1341434_1343132_-|energy-dependent-translational-throttle-protein-EttA
MATVDDKKIIFSMVGVSKIIPQNQKQILKNIYLSFFYGAKIGIIGLNGAGKSTLMKIIAGLVEPTQGEVVWSPGYSVGYLPQDPPLDEAKTVKENVMEGVQHIYDALKEYDDINVKFGLEEYYSDADKMDKLMQRQAELQDIIDATDAWNIDSRLERAMDALRCPKGDLPVTNLSGGERRRVALCRLLLQKPDVLLLDEPTNHLDAESIDWLEQHLQQYEGTVIAVTHDRYFLDDVSEWILELDRGEGIPWKGNYSSWLDQKTKRMEQEEKSASKRRKTLERELEWVRMAPKARQAKGKARLNSYEQMLNEEQKQREEKLEIFIPNGPRLGNKVIEAQHVKKAFGEKVLFNDLNFMLPPNGIVGVIGPNGAGKTTLFRLIMGLEQADGGTFEVGETVKLAYVDQQHKDIDPNKTVYDVVSQGNETIRMGGRDINSRAYLSRFNFSGTDQSKLCSVLSGGERNRLQLAMALKQEGNVLLLDEPTNDIDVNTLRALEEGLEAFAGCAVVISHDRWFLDRICTHILAFEGNGEVVYFEGGFSDYEINKARRLGNEEIKKGRYRKLMEE
>NC_014371.1|WP_013265466.1|1340325_1341171_-|hypothetical-protein
MFVLFFLCFSIYGKAQTAPKKLTAPSPERFQAINDSILAEGMWLYTYEKLAWRATDSLMKYNVKREEINSATAFEEGNLTWRYIFANLDKEQTVFELTLHLSNDTSFYVCSATPRKLKPTEIEQLKAKQIAPRKVIKEKGDSIFLANTSGLNWDLLPLEKGGYRLYLLHGTTKHGVIPIGDDYAFDFDKDMNILSWRRFHRSFLEQPITMNGEEITEVIHSHTPMTPYFTTTDIANYMLYGCDLYGIKRFSVLSTAFADTSYLTTFDVEKMKLTSTVYTVK
>NC_014371.1|WP_013265745.1|1339088_1339859_-|NYN-domain-containing-protein
MEKKLGTYLLILYFCSIKSIALLSCRVSATSEWLFLFNLHTMPKRVTFYFDGFNFYFALKRKKKISPEWKDFYWLDLVAFCESFLGPDQVLEKVIYFTASPLSPQKNSRQSAFLNANRILHSDKFEVIRGKYMSKQIECPYCKYSISKPEEKRTDVNISVRMMADCVQDKTDVIVLISADTDLIPPLNFIHTNYPNKKVKVFFPPGSHALELHNHLRTFHSKWVFLEKNERRFRNAVMPHTITVGNQSVSIPEKWK
>NC_014371.1|WP_044046157.1|1335587_1338782_+|hypothetical-protein
MLFERFLRNKSLMAAMALTAVMPSVAKASILSAAPTAEGENQQLKAGVYFIVNDKRQAGTDLHVYVDESGLHGKNYTSLAADYSNAFLLHAKGDKYTIQSLKDGKYVQNVNGNSVPYKTGNDAHKFQIVYQSQSSGTGKSYFNIYNDNVGGNQFCWHLDAQRNVVRWYPLTDNGRIALGPSEFRLDPVTSLSKQQVLDRLAELTKIVDPRKDLNKYYQIVSDTYGRAMREDYIVGELSTGGFVDTDYSYCWKLVKLGSGRYAFQNAVTGKYIAQQNGQTSRYYTTSEEQGNGFEFNLNESDPYVLTFEMVDAYNVGIHCAESQGYHPVGWYVNNEANKWVFKVATIDQAKLKEQQDAYKARVDLTRNVDRYATAVAKYFTNSAATEVTAATKAMTDEALKAQMTTEGVPQGLQEVVLKIKNQSWTVYPSGRNWEKQFRIADYKVYSENNYGAWARSMGIGYDYGSMTNPTGVTARDGEDLFVFLGDDIPQDATVQIELVPLGTRSAGKYHNLKKGLNIILNQGENNVFVNYIGRTFNNGKYLRDYKPMNIHIEGGKVNGYFDLTKGNTNEDWQKMQSDGLVWAKAFNMKGELVVMNMPSQACKDYTPVHMKELVEIWNSIVQREDDLMGFRAAKRDKCNNVLNATAVDHGYMYATTGGTYYNYNTLADVLNYDKMKWGNGTLWGPAHEFGHNHQQLFNTAGMTEISVNMYSNMVMFTSGRVTSRSEHCNYTDVDGQEHRGVCESAVSTYADRFANKKMWFEYGTWGTTQMYYKLYMMFHSTGLDDQFWHKCLDYLRTHRLEGQGTANCQGQNDYLLFAKACCVAANQDLSSFFEAWGHFYDVNGSVIGDYSNTTMYTTRAQWVEAKKFMQQFPKGPANNMIFIDDHIRPTPAIYPGAAPGTMREDFNGAVRVGTMGDFGSWDQFCPDSLGQGYAIIKTQSDANGRRTYTMEAKNSHVVGFKIYDSKGNLIYFANTKTFTIPKKVMEDAQNNIVIKVCGSDGSEVDPGTVPLGIKTFSAQANGGKVDVYSIYGVLVRSKVNPETALEGLPNGVYVVGGKKVVVGK
>NC_014371.1|WP_013265662.1|1353807_1355586_+|M6-family-metalloprotease-domain-containing-protein
MKKIITLLVSVLLATSSFAIPAMRMWRSFKQADGTILKVMTVGDEHFNYALTEDNIPVLPHNGSYYYARIEDNQLVPSSVLAHDKALRKGKEELVAAAIQQVRQLQKQHEMHVNSKPFGEGLGMTWEGKKKGLVILVEFEDVAFKDPKNVLTLKPREKDVKTLYENMLNKVGYTNDNGAIGSVHDYFLDQSNGKFDLTFDVVGPVKLKHPHQFYGERTANMNDANAPQMIIDACNAIQGQVDFSKYDWDDDGEVEQVYVIYAGEGEATGGESSTIWPHKYSLTDAGLDALTFNGQTINTYACSNEIIRAKVNEKSRIYYSGIGTICHEFSHCLGLPDFYDTRGGSNIGSGRYDLMCGGSYNGGPESLINVYGGTGIGTVPAGYDAYEKAYMGWLKPITLGDEAVEVKNMKGLAEGGDAYFLYNPDTKNEYYIFENRTPHRWDAELPGHGLMVFHVDFDAYSWRMNNLNAASAQRHPRFTIVSADGRLDHDTQNSDPFPTDLNNSLTKSTDPRLSFYTNYNVSSQAGVKQIVRNNDNTISFHFTPLKAATGINNLSADHEQLAETYTLSGVKVADNQNLHNQIVIVKGKKVRK
>NC_014371.1|WP_044046161.1|1356889_1357408_-|GNAT-family-N-acetyltransferase
MEKKQYVEVRLRAMEPEDLDMLYHIENDRSLWNISATNVPYSRYALHNYIADAKNDIYIDGQLRMMIENREQEIVGVIDLVNFDPKHQRAEMGIIIMKPFRQKGYAKAAISALIDYTRNGLHLKQIYAVVDVDNEVSIRCLSSIGFTNGSILKEWLYCDGQYKDARVMQLFI
>NC_014371.1|WP_013265628.1|1357411_1358614_-|glycosyltransferase-family-2-protein
MKLSVVIVNYNVKYYLQQCLESLQRALKGVEAEVFVVDNHSHDGSVAYLRSRFPDVHFIASAHNLGFAGGNNIAIRQSKGEYVLLLNPDTVVGEEVIHASIDFMDSHLTAGGHGVQMLTHCGERALESRRGLPSPMVSFYKMVGLCKHFPQSGRFAHYYMGSLSWDVPGKIEVISGAYCFLRRTALDKVGLLDEDFFMYGEDVDLSYRLLKGGFENWYLPVRILHYKGESTQKSSFRYVHVFYDAMLIFFRKHYGGMNVLWRLPIKTAIYVKAFGSLIGTTIRATRKKLGFRTSKAKSFPHYIFVAGEDVMGKCQRLATDNALVAEYRVADKDSLQHMHADLLKEFGGKSRAYCIVYDTDLFSYQDILNVFAEQPKQNIHIGFYHRKENRVVTMMEVIGD
>NC_014371.1|WP_013265061.1|1358614_1359067_-|hypothetical-protein
MDKTRKILLIEFFGSCLITLLIIAVYELELILPGAWADVESSNMVTVQFLMQLLTLATIPLALFLFKIGYVHSDLHTDESHVSRKLLFWGSVRIMMLCVPMILNTFFYYAFGDSVSFFYLAVILALSLFFVFPNKKRCEHECSMDNSEQA
>NC_014371.1|WP_013265871.1|1359074_1359683_-|recombination-protein-RecR
MQQYPSQLLERAVEAFSQLPGVGRKTALRLVLHLLRQSTEDVDSFADAVIRVKHDVKYCKVCHNISDNEVCSICSDPRRDASVVCVVENIQDVMAIENTQQFHGLYHVLGGIISPMDGIGPHDLEIESLVERVEEGTVKEIILALASTMEGDTTNFYISRKLKDTGVKLSVIARGISVGDELEYTDEVTLGRSILNRTPFES
>NC_014371.1|WP_044046162.1|1359866_1360361_-|outer-membrane-beta-barrel-protein
MIKRFMLLVAAMVVSISASAQFQEGKGYLGASLTGLDLHYNGHDGMNIGVQAKAGYFPWDNLMVLATFDAVHNGSEAVADHISVGVGGRYYITQNGLYLGAGVKLLHANHNYNDLMPGVEVGYAFFINRSVTIEPALYYDQSFKTHNYSTVGLKVGLGIYLFDD
>NC_014371.1|WP_013265679.1|1360761_1361019_-|hypothetical-protein
MKRIKIIRVLATFICHDPFAYSPIWTWDGFPPIIYTERERILPVLKEWEHKGYLTLIYDEKIAFILNVEKLPSKEKLIEESRNIK
>NC_014371.1|WP_044046236.1|1361074_1361281_-|hypothetical-protein
MSPIVDWNLLDVLNKNIRDNYERIRPILLKWQENGYIKLIEDNEIAFSFIPEKLPSKEKLIEESLNFK
>NC_014371.1|WP_013265392.1|1362479_1364687_-|sodium-translocating-pyrophosphatase
MEHIPQVFWLIPIASVCALGMAWYFFKSMMKAEEGTPRMVEIAEYVRRGAMAYLKQQYKVVLIVFVVLAIVFAIMAYGFNAQNEWVPFAFLTGGFFSGLAGFFGMKTATYASARTANAARNGLNDGLKIAFRSGAVMGLVVVGLGLLDIAIWFIVLTWFYSDKMTTSEMLITITTTMLTFGMGASTQALFARVGGGIYTKAADVGADLVGKVEANIPEDDPRNPATIADNVGDNVGDVAGMGADLYESYCGSILSTAALGATAFAASSGDMQLKAVIAPMLIAAVGVFLSLFGIFLVRTKEGATMKDLLHALGLGTNTAAVLIAAVSFLILYLLGLENWLGVSFSVIAGLAAGVIIGQATEYYTSQSYMPTKAISEASHTGAATVIIKGIGTGMISTCVPVLSISVAIMLSYLCANGFDMSMSALSIQHGLYGIGIAAVGMLSTLGITLATDAYGPIADNAGGNAEMSELGAEVRQRTDALDALGNTTAATGKGFAIGSAALTALALLASYIEEIKIAMARVGTQMTNVAGETIDATKATIPDFMNFFQVNLMNPKVLVGAFIGAMAAFLFCGLTMGAVGRAAGKMVEEVRRQFREIKGILEGTGTPDYGRCVEISTQSAQHEMIIPSLLAIIIPVVVGLLLGVAGVLGLLVGGLAAGFTLAVFMSNAGGAWDNAKKYVEEGNFGGKGSEAHKATIVGDTVGDPFKDTSGPSLNILIKLMSMVSIVMAGLTVACL
>NC_014371.1|WP_013265359.1|1365368_1366100_-|nitroreductase-family-protein
MKTINTRKTIRKYTNKDVSEDLLRTLLEKAERTPTMGNLQLYSVIITRNEEKKAQLAPAHFNQPMVMGAPVVLTFCADFRRTTLWAENRKATPGYDNFLSFLNAATDALLYCQTFCNLAEEEGLGTCFLGTTIYNPKTIIEVLQLPRLVMPVATITLGWPAEDPALTDRLPIDSIIHHETYEDYTPDRIDAFYTPKEQLEENKHFVEINNKETLAQVFTDLRYTKEANEAISKALLETLKGQW

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Crispr_ID: NC_014371_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014371_11

1364842-1364925

Orphan

Consensus_repeat	Method
ACCCCTCCCCCAAAGGGAGGGGAGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014371_11

>merge|NC_014371|11|1364842-1364925|CRISPRCasFinder
ACCCCTCCCCCAAAGGGAGGGGAGTGAAATGTAACGAAAGCAACTGGCCCCACCCCCCAACCCCTCCCCCATAGGGAGGGGAGT

>NC_014371|11|11|1364842-1364925|CRISPRCasFinder
ACCCCTCCCCCAAAGGGAGGGGAGT	GAAATGTAACGAAAGCAACTGGCCCCACCCCCCA
ACCCCTCCCCCATAGGGAGGGGAGT

Protein	Signature genes	Signature genes Name	Protein_function
NC_014371.1\|WP_044046161.1\|1356889_1357408_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379112
NC_014371.1\|WP_013265359.1\|1365368_1366100_-\|nitroreductase-family-protein	unknown	unknown	gnl\|CDD\|380322
NC_014371.1\|WP_013265662.1\|1353807_1355586_+\|M6-family-metalloprotease-domain-containing-protein	unknown	unknown	gnl\|CDD\|274507
NC_014371.1\|WP_013265392.1\|1362479_1364687_-\|sodium-translocating-pyrophosphatase	unknown	unknown	gnl\|CDD\|376979
NC_014371.1\|WP_013265074.1\|1351245_1352859_+\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	unknown	unknown	gnl\|CDD\|369630
NC_014371.1\|WP_013265061.1\|1358614_1359067_-\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_013265679.1\|1360761_1361019_-\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_013265626.1\|1370715_1371696_+\|MCE-family-protein	unknown	unknown	gnl\|CDD\|224380
NC_014371.1\|WP_013265871.1\|1359074_1359683_-\|recombination-protein-RecR	unknown	unknown	gnl\|CDD\|234616
NC_014371.1\|WP_044046236.1\|1361074_1361281_-\|hypothetical-protein	unknown	unknown	unknown
NC_014371.1\|WP_044046162.1\|1359866_1360361_-\|outer-membrane-beta-barrel-protein	unknown	unknown	unknown
NC_014371.1\|WP_013265834.1\|1368936_1369320_+\|dihydroneopterin-aldolase	unknown	unknown	gnl\|CDD\|376737
NC_014371.1\|WP_013265237.1\|1366197_1368798_+\|adenosylcobalamin-dependent-ribonucleoside-diphosphate-reductase	unknown	unknown	gnl\|CDD\|274168
NC_014371.1\|WP_013265897.1\|1369372_1370704_+\|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl\|CDD\|119407
NC_014371.1\|WP_013265628.1\|1357411_1358614_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|224137

Protein	Function_ID	Function_description	E-value
NC_014371.1\|WP_013265871.1\|1359074_1359683_-\|recombination-protein-RecR	gnl\|CDD\|234616	PRK00076, recR, recombination protein RecR; Reviewed.	6.95636e-114
NC_014371.1\|WP_044046161.1\|1356889_1357408_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	2.39499e-24
NC_014371.1\|WP_013265359.1\|1365368_1366100_-\|nitroreductase-family-protein	gnl\|CDD\|380322	cd02146, NfsA-like, nitroreductase similar to Escherichia coli NfsA. This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as an electron donor. Oxygen-insensitive nitroreductase, such as NfsA protein in Escherichia coli, catalyzes reduction of nitrocompounds using NADPH as electron donor.	3.3976e-74
NC_014371.1\|WP_013265662.1\|1353807_1355586_+\|M6-family-metalloprotease-domain-containing-protein	gnl\|CDD\|274507	TIGR03296, hypothetical_protein, M6 family metalloprotease domain. This model describes a metalloproteinase domain, with a characteristic HExxH motif. Examples of this domain are found in proteins in the family of immune inhibitor A, which cleaves antibacterial peptides, and in other, only distantly related proteases. This model is built to be broader and more inclusive than pfam05547.	2.71626e-55
NC_014371.1\|WP_013265392.1\|1362479_1364687_-\|sodium-translocating-pyrophosphatase	gnl\|CDD\|376979	pfam03030, H_PPase, Inorganic H+ pyrophosphatase. The H+ pyrophosphatase is an transmembrane proton pump involved in establishing the H+ electrochemical potential difference between the vacuole lumen and the cell cytosol. Vacuolar-type H(+)-translocating inorganic pyrophosphatases have long been considered to be restricted to plants and to a few species of photo-trophic bacteria. However, in recent investigations, these pyrophosphatases have been found in organisms as disparate as thermophilic Archaea and parasitic protists.	0
NC_014371.1\|WP_013265074.1\|1351245_1352859_+\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	gnl\|CDD\|369630	pfam07980, SusD_RagB, SusD family. This domain is found in bacterial cell surface proteins such SusD and SusD-like proteins, as as well RagB, outer membrane surface receptor antigen. Bacteroidetes, one of the two dominant bacterial phyla in the human gut, are Gram-negative saccharolytic microorganisms that utilize a diverse array of glycans. Hence, they express starch-utilization system (Sus) for glycan uptake. SusD has 551 amino acids, and is almost entirely alpha-helical, with 22 alpha-helices, eight of which form 4 tetra-trico peptide repeats (TPRs: helix-turn-helix motifs involved in protein-protein interactions). The four TPRs pack together to create a right-handed super-helix. This is predicted to mediate the formation of SusD and SusC porin complex at the cell surface. The interaction between SusC and TPR1/TPR2 region of SusD is predicted to be of functional importance since it allows SusD to be in position for oligosaccharide capture from other Sus lipoproteins and delivery of these glycans to the SusC porin. The non-TPR containing portion of SusD is where starch binding occurs. The binding site is a shallow surface cavity located on top of TPR1. SusD homologs such as SusD-like proteins have a critical role in carbohydrate acquisition. Both SusD and its homologs, contain about 15-20 residues at the N-terminus that might be a flexible linker region, anchoring the protein to the membrane and the glycan-binding domain. Other homologs to SusD have been examined in Porphyromonas gingivalis such as RagB, an immunodominant outer-membrane surface receptor antigen. Structural characterization of RagB shows substantial similarity with Bacteroides thetaiotaomicron SusD (i.e alpha-helices and TPR regions). Based on this structural similarity, functional studies suggest that, RagB binding of glycans occurs at pockets on the molecular surface that are distinct from those of SusD.	3.91272e-58
NC_014371.1\|WP_013265626.1\|1370715_1371696_+\|MCE-family-protein	gnl\|CDD\|224380	COG1463, Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism].	4.03207e-13
NC_014371.1\|WP_013265628.1\|1357411_1358614_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|224137	COG1216, COG1216, Predicted glycosyltransferases [General function prediction only].	6.12833e-47
NC_014371.1\|WP_013265897.1\|1369372_1370704_+\|N-acetylmuramoyl-L-alanine-amidase	gnl\|CDD\|119407	cd02696, MurNAc-LAA, N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino acids in certain cell wall glycopeptides. These proteins are Zn-dependent peptidases with highly conserved residues involved in cation co-ordination. MurNAc-LAA in this family is one of several peptidoglycan hydrolases (PGHs) found in bacterial and bacteriophage or prophage genomes that are involved in the degradation of the peptidoglycan. In Escherichia coli, there are five MurNAc-LAAs present: AmiA, AmiB, AmiC and AmiD that are periplasmic, and AmpD that is cytoplasmic. Three of these (AmiA, AmiB and AmiC) belong to this family, the other two (AmiD and AmpD) do not. E. coli AmiA, AmiB and AmiC play an important role in cleaving the septum to release daughter cells after cell division. In general, bacterial MurNAc-LAAs are members of the bacterial autolytic system and carry a signal peptide in their N-termini that allows their transport across the cytoplasmic membrane. However, the bacteriophage MurNAc-LAAs are endolysins since these phage-encoded enzymes break down bacterial peptidoglycan at the terminal stage of the phage reproduction cycle. As opposed to autolysins, almost all endolysins have no signal peptides and their translocation through the cytoplasmic membrane is thought to proceed with the help of phage-encoded holin proteins. The amidase catalytic module is fused to another functional module (cell wall binding module or CWBM) either at the N- or C-terminus, which is responsible for high affinity binding of the protein to the cell wall.	8.66866e-60
NC_014371.1\|WP_013265237.1\|1366197_1368798_+\|adenosylcobalamin-dependent-ribonucleoside-diphosphate-reductase	gnl\|CDD\|274168	TIGR02504, ribonucleotide_reductase, ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent. This model represents a group of adenosylcobalamin(B12)-dependent ribonucleotide reductases (Class II RNRs) related to the characterized species from Pyrococcus, Thermoplasma, Corynebacterium, and Deinococcus. RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. This model identifies genes in a wide range of deeply branching bacteria. All are structurally related to the class I (non-heme iron dependent) RNRs. In most species this gene is known as NrdJ, while in mycobacteria it is called NrdZ. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism].	0
NC_014371.1\|WP_013265834.1\|1368936_1369320_+\|dihydroneopterin-aldolase	gnl\|CDD\|376737	pfam02152, FolB, Dihydroneopterin aldolase. This enzyme EC:4.1.2.25 catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin in the biosynthetic pathway of tetrahydrofolate.	1.97542e-37

>NC_014371.1|WP_013265392.1|1362479_1364687_-|sodium-translocating-pyrophosphatase
MEHIPQVFWLIPIASVCALGMAWYFFKSMMKAEEGTPRMVEIAEYVRRGAMAYLKQQYKVVLIVFVVLAIVFAIMAYGFNAQNEWVPFAFLTGGFFSGLAGFFGMKTATYASARTANAARNGLNDGLKIAFRSGAVMGLVVVGLGLLDIAIWFIVLTWFYSDKMTTSEMLITITTTMLTFGMGASTQALFARVGGGIYTKAADVGADLVGKVEANIPEDDPRNPATIADNVGDNVGDVAGMGADLYESYCGSILSTAALGATAFAASSGDMQLKAVIAPMLIAAVGVFLSLFGIFLVRTKEGATMKDLLHALGLGTNTAAVLIAAVSFLILYLLGLENWLGVSFSVIAGLAAGVIIGQATEYYTSQSYMPTKAISEASHTGAATVIIKGIGTGMISTCVPVLSISVAIMLSYLCANGFDMSMSALSIQHGLYGIGIAAVGMLSTLGITLATDAYGPIADNAGGNAEMSELGAEVRQRTDALDALGNTTAATGKGFAIGSAALTALALLASYIEEIKIAMARVGTQMTNVAGETIDATKATIPDFMNFFQVNLMNPKVLVGAFIGAMAAFLFCGLTMGAVGRAAGKMVEEVRRQFREIKGILEGTGTPDYGRCVEISTQSAQHEMIIPSLLAIIIPVVVGLLLGVAGVLGLLVGGLAAGFTLAVFMSNAGGAWDNAKKYVEEGNFGGKGSEAHKATIVGDTVGDPFKDTSGPSLNILIKLMSMVSIVMAGLTVACL
>NC_014371.1|WP_044046236.1|1361074_1361281_-|hypothetical-protein
MSPIVDWNLLDVLNKNIRDNYERIRPILLKWQENGYIKLIEDNEIAFSFIPEKLPSKEKLIEESLNFK
>NC_014371.1|WP_013265679.1|1360761_1361019_-|hypothetical-protein
MKRIKIIRVLATFICHDPFAYSPIWTWDGFPPIIYTERERILPVLKEWEHKGYLTLIYDEKIAFILNVEKLPSKEKLIEESRNIK
>NC_014371.1|WP_044046162.1|1359866_1360361_-|outer-membrane-beta-barrel-protein
MIKRFMLLVAAMVVSISASAQFQEGKGYLGASLTGLDLHYNGHDGMNIGVQAKAGYFPWDNLMVLATFDAVHNGSEAVADHISVGVGGRYYITQNGLYLGAGVKLLHANHNYNDLMPGVEVGYAFFINRSVTIEPALYYDQSFKTHNYSTVGLKVGLGIYLFDD
>NC_014371.1|WP_013265871.1|1359074_1359683_-|recombination-protein-RecR
MQQYPSQLLERAVEAFSQLPGVGRKTALRLVLHLLRQSTEDVDSFADAVIRVKHDVKYCKVCHNISDNEVCSICSDPRRDASVVCVVENIQDVMAIENTQQFHGLYHVLGGIISPMDGIGPHDLEIESLVERVEEGTVKEIILALASTMEGDTTNFYISRKLKDTGVKLSVIARGISVGDELEYTDEVTLGRSILNRTPFES
>NC_014371.1|WP_013265061.1|1358614_1359067_-|hypothetical-protein
MDKTRKILLIEFFGSCLITLLIIAVYELELILPGAWADVESSNMVTVQFLMQLLTLATIPLALFLFKIGYVHSDLHTDESHVSRKLLFWGSVRIMMLCVPMILNTFFYYAFGDSVSFFYLAVILALSLFFVFPNKKRCEHECSMDNSEQA
>NC_014371.1|WP_013265628.1|1357411_1358614_-|glycosyltransferase-family-2-protein
MKLSVVIVNYNVKYYLQQCLESLQRALKGVEAEVFVVDNHSHDGSVAYLRSRFPDVHFIASAHNLGFAGGNNIAIRQSKGEYVLLLNPDTVVGEEVIHASIDFMDSHLTAGGHGVQMLTHCGERALESRRGLPSPMVSFYKMVGLCKHFPQSGRFAHYYMGSLSWDVPGKIEVISGAYCFLRRTALDKVGLLDEDFFMYGEDVDLSYRLLKGGFENWYLPVRILHYKGESTQKSSFRYVHVFYDAMLIFFRKHYGGMNVLWRLPIKTAIYVKAFGSLIGTTIRATRKKLGFRTSKAKSFPHYIFVAGEDVMGKCQRLATDNALVAEYRVADKDSLQHMHADLLKEFGGKSRAYCIVYDTDLFSYQDILNVFAEQPKQNIHIGFYHRKENRVVTMMEVIGD
>NC_014371.1|WP_044046161.1|1356889_1357408_-|GNAT-family-N-acetyltransferase
MEKKQYVEVRLRAMEPEDLDMLYHIENDRSLWNISATNVPYSRYALHNYIADAKNDIYIDGQLRMMIENREQEIVGVIDLVNFDPKHQRAEMGIIIMKPFRQKGYAKAAISALIDYTRNGLHLKQIYAVVDVDNEVSIRCLSSIGFTNGSILKEWLYCDGQYKDARVMQLFI
>NC_014371.1|WP_013265662.1|1353807_1355586_+|M6-family-metalloprotease-domain-containing-protein
MKKIITLLVSVLLATSSFAIPAMRMWRSFKQADGTILKVMTVGDEHFNYALTEDNIPVLPHNGSYYYARIEDNQLVPSSVLAHDKALRKGKEELVAAAIQQVRQLQKQHEMHVNSKPFGEGLGMTWEGKKKGLVILVEFEDVAFKDPKNVLTLKPREKDVKTLYENMLNKVGYTNDNGAIGSVHDYFLDQSNGKFDLTFDVVGPVKLKHPHQFYGERTANMNDANAPQMIIDACNAIQGQVDFSKYDWDDDGEVEQVYVIYAGEGEATGGESSTIWPHKYSLTDAGLDALTFNGQTINTYACSNEIIRAKVNEKSRIYYSGIGTICHEFSHCLGLPDFYDTRGGSNIGSGRYDLMCGGSYNGGPESLINVYGGTGIGTVPAGYDAYEKAYMGWLKPITLGDEAVEVKNMKGLAEGGDAYFLYNPDTKNEYYIFENRTPHRWDAELPGHGLMVFHVDFDAYSWRMNNLNAASAQRHPRFTIVSADGRLDHDTQNSDPFPTDLNNSLTKSTDPRLSFYTNYNVSSQAGVKQIVRNNDNTISFHFTPLKAATGINNLSADHEQLAETYTLSGVKVADNQNLHNQIVIVKGKKVRK
>NC_014371.1|WP_013265074.1|1351245_1352859_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein
MKTVRTYILAGVAAFALTSCNDYLTTVPKDAMSPSTTWKTGDDAEKFLVGCYDGWEDGGALLYWDAGSDFAYNNFPWEGFTNIGNGSLSPSSPGWSFYDYTIIGRCNTFLENVDKCVFSSDAVKKDLVAQVKAIRAYNYFRMGFLYGGVPIVKPFTSAQEARVPRNTEQEVKDLVFKDLDEAIADINTSPAARGRIAKGAALAMKMRAALYWGDYQKAKDAAQAIIDLGKYELDPDYTNLFKLAGVDSKEIILAVQYKSGTRPLGTIGQLYNNGDGGWSSVVPTQKCVDNYEMSNGMTITEAGSGYDATHPFHGRDPRMAMTILYPGCDWEGTIFNTLDENVNGKKNPNYPTNAANSSKTALTWRKYLDPKTQYADVWDTEACPIVFRYAEVLLTWAEAENELNGPSANVYAMIDKVRTRVGMPAVDQSKYNTKDKLRELIRRERGSEFAGEGLRRADILRWTSNGKMVAETVLNGPLNRITGTINTSATDPTMRAVVSGSSKVEDRTFQTFNRYLPIPQWNISDNPKLEQNPGYAK
>NC_014371.1|WP_013265359.1|1365368_1366100_-|nitroreductase-family-protein
MKTINTRKTIRKYTNKDVSEDLLRTLLEKAERTPTMGNLQLYSVIITRNEEKKAQLAPAHFNQPMVMGAPVVLTFCADFRRTTLWAENRKATPGYDNFLSFLNAATDALLYCQTFCNLAEEEGLGTCFLGTTIYNPKTIIEVLQLPRLVMPVATITLGWPAEDPALTDRLPIDSIIHHETYEDYTPDRIDAFYTPKEQLEENKHFVEINNKETLAQVFTDLRYTKEANEAISKALLETLKGQW
>NC_014371.1|WP_013265237.1|1366197_1368798_+|adenosylcobalamin-dependent-ribonucleoside-diphosphate-reductase
METKQTYSFDEAFQASLAYFGGDELAARVWVNKYAMKDSFGNIYEKSPEQMHWRIANEIARIENKYKNPLTAQEVFDLLHHFKYIIPAGSPMTGIGNNYQVASLSNCFVIGLDGNADSYGAIMRIDEEQVQLMKRRGGVGHDLTHIRPKGSPVNNSALTSTGLVPFMERYSNSTREVAQDGRRGALMLSVSIKHPDSEAFIDAKMEEGKVTGANVSVKITDEFMQAVVEDKTYVQQFPTNSSEPSVTKEISAKELWEKIVHNAWKSAEPGVLFWDTIIRESIPDCYADLGFQTVSTNPCGEIPLCPYDSCRLLSLNLYSYVIDPFTDHARFDMELFKRHAQLAQRLMDDIIDLEMEKIDLIMSKIKTDPQVDEVKSAEYHLWEKIKKKSCQGRRTGVGITAEGDMIAAMGLRYGTQEATDFSVDIHRTLALNAYRSSVTMAQERGAFEIYDAKREEKNPFILRLKEADGQLYEDMKKYGRRNIACLTIAPTGTTSLMTQTTSGIEPVFMPVYKRRRKVNPNDTDVHVDFVDEVGDSFEEYIVYHRKFLTWMEVNGIDTQKKYSQEEIDELVKRSPYYKATANDVDWLMKVRMQGEIQKWVDHSISVTVNLPNQVDEELVNKLYVEAWRSGCKGCTIYRDGSRSGVMISVSKKDKTKDEKPVDEEKVKDLNSAEEHHEHICNHPNVIEVRPKELECDVVRFQNNKEKWVAFVGLLEGYPYEIFTGLQDDEEGIALPKSVTKGKIIKQTAEDGSHRYDFQFENKRGYKTTVEGLSEKFNPEYWNYAKLISGVLRYRMPIDHVIKLVGSLQLKNESINTWKNGVERALKKYVVDGTSASGLKCPVCGQETLVYQEGCLICTNCGASRCG
>NC_014371.1|WP_013265834.1|1368936_1369320_+|dihydroneopterin-aldolase
MKLMTSYILLQGLHFHACIGVGEQERVVGNEYVLDLRLGYPFVTAMKSDDVADTLNYAEVFNVIREVMKQPVRLLESVAGSIVEALFAVFPMISSIDLKLVKLNPPMGADSDGAGVELHLINDKTEV
>NC_014371.1|WP_013265897.1|1369372_1370704_+|N-acetylmuramoyl-L-alanine-amidase
MFKKISLLLVFLVLSVSLSWAADGRFTLVIDPGHGGHDAGAIGAISKEKDINLNIALAFGRYVERNLPDVNVIYTRKTDVFIPLHQRADIANKAKADLFISVHTNSVASGRYVKGFQVYTLGMHRAKANLDVAMRENGVISMEKGYQQTYQGFDPNSSESYIMFEFMQNANMERSVELARMIQNSVCSSAGRIDKGVHQAGFLVLRESYMPSCLIELGFITAADEEEYLNSPAGIDAMAKGIYNAFVQYKNAYDTRIVVPYRPVENKRIVIDRVVPTAPTTKPHPVTPIERPRSVAPVQRSRSTVPVEQPRSSTPAPPARPMNKVQEAKKRISDAIRELLPCNDSEAETAKSVPVFKVQVLASNRQLRSGSELFRGHTDIDCVQEGNFYKYCIGSSTNYNDISRLRGKLLKDFSQACIIAYKNGARMDVNQAIAEFLKNKKNK
>NC_014371.1|WP_013265626.1|1370715_1371696_+|MCE-family-protein
MKKFFTPQVRIAIVAILAIVVLFFGIQFLRGISLFSNDAHYKIKFNDITGLSTSTPVYARGFKVGIVRNIDYDYDKLGESITVDIDVEKTLRIPEGTTAEIVSDIMGNVKVVLQFGKSTKLLEPNGWIDGVINDGTLGDLKSMVPSIQKMLPKLDSILGSVNTLLGDPALQSSVHNIDKITANLTTSTRELNTLLAQVNGSLPVVAAKAGRVMDNANGMMVNANRGVTEARGAIRGANTMMSNLNNKVNGLDVEATVAKVNATLDNMNSLTAKLNSNEGTMGLMLNDASLYNNLNSTMRSADSLLTNLKAHPKRYVHFSIFGRKDK

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_014371_6	6.1\|1189601\|57\|NC_014371\|CRISPRCasFinder	1189601-1189657	57	NC_014371.1	1328682-1328738	0	1.0
NC_014371_6	6.1\|1189601\|57\|NC_014371\|CRISPRCasFinder	1189601-1189657	57	NC_014371.1	1328766-1328822	0	1.0

1. spacer 6.1|1189601|57|NC_014371|CRISPRCasFinder matches to position: 1328682-1328738, mismatch: 0, identity: 1.0

acttattgctatataattcgtgtcattcgcgtaattcgcagtcaactttttgattag	CRISPR spacer
acttattgctatataattcgtgtcattcgcgtaattcgcagtcaactttttgattag	Protospacer
*********************************************************

2. spacer 6.1|1189601|57|NC_014371|CRISPRCasFinder matches to position: 1328766-1328822, mismatch: 0, identity: 1.0

acttattgctatataattcgtgtcattcgcgtaattcgcagtcaactttttgattag	CRISPR spacer
acttattgctatataattcgtgtcattcgcgtaattcgcagtcaactttttgattag	Protospacer
*********************************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_014371_10	10.1\|1353350\|29\|NC_014371\|CRISPRCasFinder	1353350-1353378	29	NZ_CP020004	Bacillus thuringiensis strain Bacillus thuringiensis L-7601 plasmid unnamed2, complete sequence	38937-38965	7	0.759
NC_014371_10	10.1\|1353350\|29\|NC_014371\|CRISPRCasFinder	1353350-1353378	29	NC_048762	Bacillus phage vB_BtS_B83, complete genome	5072-5100	7	0.759
NC_014371_10	10.1\|1353350\|29\|NC_014371\|CRISPRCasFinder	1353350-1353378	29	KY290956	Aeromonas phage L9-6, complete genome	93770-93798	8	0.724
NC_014371_10	10.1\|1353350\|29\|NC_014371\|CRISPRCasFinder	1353350-1353378	29	KY290951	Aeromonas phage 31.2, complete genome	93171-93199	8	0.724
NC_014371_10	10.1\|1353350\|29\|NC_014371\|CRISPRCasFinder	1353350-1353378	29	NC_005135	Aeromonas phage 44RR2.8t, complete genome	93412-93440	8	0.724
NC_014371_10	10.1\|1353350\|29\|NC_014371\|CRISPRCasFinder	1353350-1353378	29	AY962392	Aeromonas phage 31, complete genome	93174-93202	8	0.724
NC_014371_10	10.1\|1353350\|29\|NC_014371\|CRISPRCasFinder	1353350-1353378	29	KY290958	Aeromonas phage SW69-9, complete genome	93306-93334	8	0.724
NC_014371_10	10.1\|1353350\|29\|NC_014371\|CRISPRCasFinder	1353350-1353378	29	AY375531	Bacteriophage 44RR2.8t, complete genome	93412-93440	8	0.724
NC_014371_10	10.1\|1353350\|29\|NC_014371\|CRISPRCasFinder	1353350-1353378	29	KY290948	Aeromonas phage 44RR2.8t.2, complete genome	93412-93440	8	0.724
NC_014371_10	10.1\|1353350\|29\|NC_014371\|CRISPRCasFinder	1353350-1353378	29	KY290957	Aeromonas phage Riv-10, complete genome	94507-94535	8	0.724

1. spacer 10.1|1353350|29|NC_014371|CRISPRCasFinder matches to NZ_CP020004 (Bacillus thuringiensis strain Bacillus thuringiensis L-7601 plasmid unnamed2, complete sequence) position: , mismatch: 7, identity: 0.759

agtaacagatgaacaggtgtttagtggac	CRISPR spacer
agtaacagaggaacaagtgtttatgcctc	Protospacer
********* *****.*******     *

2. spacer 10.1|1353350|29|NC_014371|CRISPRCasFinder matches to NC_048762 (Bacillus phage vB_BtS_B83, complete genome) position: , mismatch: 7, identity: 0.759

agtaacagatgaacaggtgtttagtggac	CRISPR spacer
agtaacagaggaacaagtgtttatgcctc	Protospacer
********* *****.*******     *

3. spacer 10.1|1353350|29|NC_014371|CRISPRCasFinder matches to KY290956 (Aeromonas phage L9-6, complete genome) position: , mismatch: 8, identity: 0.724

agtaacagatgaacaggtgtttagtggac	CRISPR spacer
agtaacagaagaacaggtgttcgactgca	Protospacer
********* ***********.... *

4. spacer 10.1|1353350|29|NC_014371|CRISPRCasFinder matches to KY290951 (Aeromonas phage 31.2, complete genome) position: , mismatch: 8, identity: 0.724

agtaacagatgaacaggtgtttagtggac	CRISPR spacer
agtaacagaagaacaggtgttcgactgca	Protospacer
********* ***********.... *

5. spacer 10.1|1353350|29|NC_014371|CRISPRCasFinder matches to NC_005135 (Aeromonas phage 44RR2.8t, complete genome) position: , mismatch: 8, identity: 0.724

agtaacagatgaacaggtgtttagtggac	CRISPR spacer
agtaacagaagaacaggtgttcgactgca	Protospacer
********* ***********.... *

6. spacer 10.1|1353350|29|NC_014371|CRISPRCasFinder matches to AY962392 (Aeromonas phage 31, complete genome) position: , mismatch: 8, identity: 0.724

agtaacagatgaacaggtgtttagtggac	CRISPR spacer
agtaacagaagaacaggtgttcgactgca	Protospacer
********* ***********.... *

7. spacer 10.1|1353350|29|NC_014371|CRISPRCasFinder matches to KY290958 (Aeromonas phage SW69-9, complete genome) position: , mismatch: 8, identity: 0.724

agtaacagatgaacaggtgtttagtggac	CRISPR spacer
agtaacagaagaacaggtgttcgactgca	Protospacer
********* ***********.... *

8. spacer 10.1|1353350|29|NC_014371|CRISPRCasFinder matches to AY375531 (Bacteriophage 44RR2.8t, complete genome) position: , mismatch: 8, identity: 0.724

agtaacagatgaacaggtgtttagtggac	CRISPR spacer
agtaacagaagaacaggtgttcgactgca	Protospacer
********* ***********.... *

9. spacer 10.1|1353350|29|NC_014371|CRISPRCasFinder matches to KY290948 (Aeromonas phage 44RR2.8t.2, complete genome) position: , mismatch: 8, identity: 0.724

agtaacagatgaacaggtgtttagtggac	CRISPR spacer
agtaacagaagaacaggtgttcgactgca	Protospacer
********* ***********.... *

10. spacer 10.1|1353350|29|NC_014371|CRISPRCasFinder matches to KY290957 (Aeromonas phage Riv-10, complete genome) position: , mismatch: 8, identity: 0.724

agtaacagatgaacaggtgtttagtggac	CRISPR spacer
agtaacagaagaacaggtgttcgactgca	Protospacer
********* ***********.... *

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

174965 : 249051

Tupanvirus(18.18%)

tRNA,transposase,holin,protease

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_044046169.1\|174965_177509_+\|protease	zinc-dependent metalloprotease	NA	NA	NA	NA
WP_044046033.1\|177505_180142_+\|protease	zinc-dependent metalloprotease	NA	NA	NA	NA
WP_013265289.1\|180753_181059_-	hypothetical protein	NA	NA	NA	NA
WP_013265805.1\|181063_181417_-\|holin	phage holin family protein	NA	NA	NA	NA
WP_004360299.1\|181427_181643_-	YtxH domain-containing protein	NA	NA	NA	NA
WP_013265192.1\|181875_182370_+	SPOR domain-containing protein	NA	NA	NA	NA
WP_013265447.1\|182370_182790_+	Holliday junction resolvase RuvX	NA	NA	NA	NA
WP_013265431.1\|182943_183504_+	peptide deformylase	E3SLL2	Synechococcus_phage	1.1e-17	41.4
WP_013265522.1\|183508_184123_+	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_013265864.1\|185387_187706_-	glycoside hydrolase family 3 C-terminal domain-containing protein	NA	NA	NA	NA
WP_013265827.1\|187756_188755_-	hypothetical protein	NA	NA	NA	NA
WP_013265918.1\|188821_190597_-	SusD/RagB family nutrient-binding outer membrane lipoprotein	NA	NA	NA	NA
WP_013265148.1\|190655_193832_-	SusC/RagA family TonB-linked outer membrane protein	NA	NA	NA	NA
WP_013265520.1\|193859_195074_-	glycoside hydrolase family 5 protein	NA	NA	NA	NA
WP_044046034.1\|195574_196792_+\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_013265459.1\|197483_201500_-	response regulator	A0A1V0SGX0	Hokovirus	7.4e-20	25.3
WP_013265405.1\|202889_204839_-\|tRNA	threonine--tRNA ligase	A0A2K9L6B6	Tupanvirus	2.3e-120	36.4
WP_009436028.1\|205224_205905_+	translation initiation factor IF-3	A0A1L2CV30	Pectobacterium_phage	2.6e-10	35.3
WP_009436018.1\|206018_206216_+	50S ribosomal protein L35	NA	NA	NA	NA
WP_004383393.1\|206251_206596_+	50S ribosomal protein L20	NA	NA	NA	NA
WP_167310039.1\|206976_207681_+	hypothetical protein	NA	NA	NA	NA
WP_044046035.1\|207731_208166_-	hypothetical protein	NA	NA	NA	NA
WP_013265814.1\|208230_208728_-	hypothetical protein	NA	NA	NA	NA
WP_174254491.1\|208734_211320_-	helix-hairpin-helix domain-containing protein	NA	NA	NA	NA
WP_044046036.1\|211509_212040_-	50S ribosomal protein L19	NA	NA	NA	NA
WP_044046171.1\|212063_212636_-	murein L,D-transpeptidase catalytic domain family protein	NA	NA	NA	NA
WP_044046172.1\|212853_214995_-	M3 family metallopeptidase	A0A1V0SID3	Klosneuvirus	5.7e-27	22.0
WP_013265502.1\|215701_216712_-	iron ABC transporter permease	NA	NA	NA	NA
WP_044046173.1\|216733_217864_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_013265348.1\|217994_219461_+	SLC13/DASS family transporter	NA	NA	NA	NA
WP_044046037.1\|219500_220202_+	hypothetical protein	NA	NA	NA	NA
WP_044046038.1\|220451_220898_+	YhcH/YjgK/YiaL family protein	NA	NA	NA	NA
WP_013265690.1\|221620_223321_+	thiol-activated cytolysin family protein	NA	NA	NA	NA
WP_013265798.1\|223415_226241_+\|protease	thiol protease/hemagglutinin PrtT	NA	NA	NA	NA
WP_013265372.1\|226791_229287_-	TonB-dependent receptor	NA	NA	NA	NA
WP_044046174.1\|229778_230852_-	zinc ribbon domain-containing protein	NA	NA	NA	NA
WP_013265267.1\|230974_233062_-	U32 family peptidase	Q6DW11	Phage_TP	1.5e-27	28.8
WP_013265300.1\|233456_234344_-	homoserine O-succinyltransferase	NA	NA	NA	NA
WP_044046039.1\|234710_236744_-	M13 family metallopeptidase	A0A1V0SHG2	Klosneuvirus	5.3e-75	27.1
WP_013265888.1\|236935_238936_-	ABC-F family ATP-binding cassette domain-containing protein	A0A2K9L3Z8	Tupanvirus	1.0e-54	29.8
WP_013265444.1\|240003_241308_-	serpin family protein	A0A1C9KBZ2	Skunkpox_virus	9.8e-22	23.0
WP_013265559.1\|241510_242731_+	uracil-xanthine permease	Q9KX94	Enterobacteria_phage	3.8e-52	34.7
WP_013265075.1\|243323_243650_-	hypothetical protein	NA	NA	NA	NA
WP_013265213.1\|243750_244998_-	radical SAM family heme chaperone HemW	NA	NA	NA	NA
WP_013265469.1\|245202_247365_+	elongation factor G	A0A2K5B2A5	Erysipelothrix_phage	6.8e-28	22.9
WP_013264582.1\|247818_249051_-\|transposase	IS4 family transposase	NA	NA	NA	NA

DBSCAN-SWA_2

384378 : 391992

Prochlorococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013265661.1\|384378_385089_-	response regulator transcription factor	A0A2R2ZGH8	Clostridioides_phage	7.2e-19	30.3
WP_036924897.1\|385063_386146_-	sensor histidine kinase	Q9EYF3	Enterobacteria_phage	1.1e-07	25.2
WP_013265046.1\|386397_387003_-	riboflavin synthase	A0A2I2L4R9	Orpheovirus	1.6e-22	35.9
WP_013265698.1\|387760_389125_-	dihydrolipoyl dehydrogenase	A0A2K5B2C5	Erysipelothrix_phage	2.3e-53	33.5
WP_013265879.1\|389159_390650_-	aminomethyl-transferring glycine dehydrogenase subunit GcvPB	M4QFZ1	Prochlorococcus_phage	2.8e-81	39.2
WP_013265407.1\|390681_391992_-	aminomethyl-transferring glycine dehydrogenase subunit GcvPA	E3ST28	Prochlorococcus_phage	2.6e-59	37.3

DBSCAN-SWA_3

745907 : 821860

Staphylococcus_phage(20.0%)

transposase,integrase

attL 820038:820052|attR 823360:823374

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_044046075.1\|745907_746777_-\|transposase	transposase	NA	NA	NA	NA
WP_013265111.1\|746892_747237_-	hypothetical protein	NA	NA	NA	NA
WP_013265302.1\|747759_748737_+	FecR family protein	NA	NA	NA	NA
WP_013265622.1\|748811_751871_+	DUF4981 domain-containing protein	L0N6M2	Herpes_simplex_virus	1.3e-152	33.6
WP_013265282.1\|752209_752365_-	hypothetical protein	NA	NA	NA	NA
WP_013265825.1\|752379_753270_-	RluA family pseudouridine synthase	NA	NA	NA	NA
WP_013265566.1\|753404_753938_-	HDIG domain-containing protein	NA	NA	NA	NA
WP_013265665.1\|754027_755806_-	biotin/lipoyl-binding protein	NA	NA	NA	NA
WP_013265170.1\|755947_756763_+	hypothetical protein	NA	NA	NA	NA
WP_013265262.1\|757502_758336_+	MotA/TolQ/ExbB proton channel family protein	NA	NA	NA	NA
WP_044046193.1\|758623_759139_+	hypothetical protein	NA	NA	NA	NA
WP_013265174.1\|759135_759681_+	biopolymer transporter ExbD	NA	NA	NA	NA
WP_013265350.1\|759677_760154_+	biopolymer transporter ExbD	NA	NA	NA	NA
WP_004359634.1\|760249_760759_+	Lrp/AsnC family transcriptional regulator	NA	NA	NA	NA
WP_013265713.1\|761400_763023_-	MFS transporter	NA	NA	NA	NA
WP_044046076.1\|763211_765371_-	S9 family peptidase	NA	NA	NA	NA
WP_013265155.1\|765373_767305_-	membrane protein insertase YidC	NA	NA	NA	NA
WP_013265730.1\|767305_768916_-	CTP synthase	A0A1J0FA14	Only_Syngen_Nebraska_virus	2.2e-132	47.2
WP_044046194.1\|769712_769958_+	hypothetical protein	NA	NA	NA	NA
WP_013265441.1\|769954_770680_+	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_013265714.1\|770886_771699_+	PepSY domain-containing protein	NA	NA	NA	NA
WP_013265545.1\|772633_774253_+	BACON domain-containing protein	NA	NA	NA	NA
WP_013265519.1\|774289_775891_+	BACON domain-containing protein	NA	NA	NA	NA
WP_013265837.1\|775906_778663_+	S8 family serine peptidase	A0A1B0T6A2	Bacillus_phage	3.9e-20	28.9
WP_044046077.1\|778674_779628_+	PorV/PorQ family protein	NA	NA	NA	NA
WP_013265887.1\|779672_781247_+	hypothetical protein	NA	NA	NA	NA
WP_013265123.1\|782384_784061_+	type I restriction-modification system subunit M	A0A2H4PQP4	Staphylococcus_phage	8.4e-34	25.7
WP_013265449.1\|784074_785298_+	restriction endonuclease subunit S	NA	NA	NA	NA
WP_013265602.1\|785313_788514_+	type I restriction endonuclease subunit R	A0A220A398	Liberibacter_phage	7.6e-68	29.1
WP_013265601.1\|788899_790045_-	DUF1735 domain-containing protein	NA	NA	NA	NA
WP_013265322.1\|790085_791204_-	endoglycosidase	NA	NA	NA	NA
WP_013265381.1\|791221_792847_-	SusD/RagB family nutrient-binding outer membrane lipoprotein	NA	NA	NA	NA
WP_013265872.1\|792853_795964_-	SusC/RagA family TonB-linked outer membrane protein	NA	NA	NA	NA
WP_004359657.1\|796317_797421_-	Mrp/NBP35 family ATP-binding protein	NA	NA	NA	NA
WP_013265397.1\|797551_797929_-	hypothetical protein	NA	NA	NA	NA
WP_044046079.1\|799955_800471_+	hypothetical protein	NA	NA	NA	NA
WP_146160291.1\|800582_800813_+	hypothetical protein	NA	NA	NA	NA
WP_036925686.1\|801463_801763_+	hypothetical protein	NA	NA	NA	NA
WP_013265120.1\|801770_802115_+	hypothetical protein	NA	NA	NA	NA
WP_013265804.1\|802250_802724_+	hypothetical protein	NA	NA	NA	NA
WP_013265216.1\|803939_804413_+	hypothetical protein	NA	NA	NA	NA
WP_044046080.1\|804675_805203_+	hypothetical protein	NA	NA	NA	NA
WP_013265355.1\|807386_807731_-\|transposase	transposase family protein	NA	NA	NA	NA
WP_013265873.1\|807936_809598_-\|transposase	IS1182 family transposase	A0A146ICT8	Staphylococcus_phage	5.2e-60	32.7
WP_013265047.1\|809938_810736_+	phosphatidylserine synthase	NA	NA	NA	NA
WP_044046083.1\|811870_813088_+\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_013265412.1\|813830_815891_+	AAA family ATPase	NA	NA	NA	NA
WP_009228984.1\|815878_816187_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_013265648.1\|816563_817496_+	Abi family protein	A0A059NT88	Lactococcus_phage	1.4e-14	25.4
WP_013265910.1\|817537_819055_-	helicase	A0A248SL14	Klebsiella_phage	4.3e-37	28.9
WP_013265494.1\|819366_820587_+\|integrase	tyrosine-type recombinase/integrase	H7BUI8	unidentified_phage	2.2e-23	31.1
820038:820052	attL	NA	NA	NA	NA
WP_013265284.1\|820591_821860_+\|integrase	site-specific integrase	H7BUI8	unidentified_phage	6.0e-24	35.2
WP_013265284.1\|820591_821860_+\|integrase	site-specific integrase	H7BUI8	unidentified_phage	6.0e-24	35.2
823360:823374	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr_ID: NC_014371.1|WP_013265106.1|912067_912487_-|PcfK-like-family-protein

Click the colored protein region to show detailed information

Acr_ID: NC_014371.1|WP_006256421.1|1093391_1093811_+|PcfK-like-family-protein

Click the colored protein region to show detailed information

Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NC_014371.1|WP_013265106.1|912067_912487_-|PcfK-like-family-protein

912067_912487_-

139 aa aa

hit_Aca_id	identity	query_coverage	hit_coverage
gnl\|BL_ORD_ID\|40	0.6099290780141844	1	1.0

NC_014371.1|WP_006256421.1|1093391_1093811_+|PcfK-like-family-protein

1093391_1093811_+

139 aa aa

hit_Aca_id	identity	query_coverage	hit_coverage
gnl\|BL_ORD_ID\|40	0.6028368794326241	1	1.0

2. NC_014370

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NC_014370_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014370_1

25855-25944

Orphan

Consensus_repeat	Method
CCTCCAATAAGATGGTTTTATAAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014370_1

>merge|NC_014370|1|25855-25944|CRISPRCasFinder
CCTCCAATAAGATGGTTTTATAAAGGCTCAACACCCAACACCCATCACCCAACACCGGTATAATTGCCCCCAATAAGATGGTTTTATAAA

>NC_014370|1|1|25855-25944|CRISPRCasFinder
CCTCCAATAAGATGGTTTTATAAA	GGCTCAACACCCAACACCCATCACCCAACACCGGTATAATTG
CCCCCAATAAGATGGTTTTATAAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_014370.1\|WP_013264971.1\|35572_37087_-\|RNA-polymerase-factor-sigma-54	unknown	unknown	gnl\|CDD\|274109
NC_014370.1\|WP_013264684.1\|19260_20103_+\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|234599
NC_014370.1\|WP_013264085.1\|21289_23950_+\|DNA-mismatch-repair-protein-MutS	unknown	unknown	gnl\|CDD\|235444
NC_014370.1\|WP_013264633.1\|30663_31722_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|377675
NC_014370.1\|WP_013264010.1\|37133_37784_-\|hypothetical-protein	unknown	unknown	unknown
NC_014370.1\|WP_004358931.1\|34914_35532_-\|hypothetical-protein	unknown	unknown	unknown
NC_014370.1\|WP_004358967.1\|15023_16070_+\|ribonucleotide-diphosphate-reductase-subunit-beta	unknown	unknown	gnl\|CDD\|236591
NC_014370.1\|WP_013264680.1\|24411_25035_-\|hypothetical-protein	unknown	unknown	unknown
NC_014370.1\|WP_013264559.1\|16971_17781_+\|DUF3108-domain-containing-protein	unknown	unknown	gnl\|CDD\|378635
NC_014370.1\|WP_013264553.1\|28750_29740_-\|aminodeoxychorismate-synthase-component-I	unknown	unknown	gnl\|CDD\|235932
NC_014370.1\|WP_013264915.1\|32183_34112_-\|4-hydroxy-3-methylbut-2-en-1-yl-diphosphate-synthase	unknown	unknown	gnl\|CDD\|179361
NC_014370.1\|WP_004358965.1\|18084_19188_+\|redox-regulated-ATPase-YchF	unknown	unknown	gnl\|CDD\|236583
NC_014370.1\|WP_013265023.1\|29781_30423_-\|NAD(P)H-binding-protein	unknown	unknown	gnl\|CDD\|187560
NC_014370.1\|WP_013264853.1\|20709_21096_+\|lipoprotein	unknown	unknown	unknown
NC_014370.1\|WP_013264242.1\|26685_28011_+\|RNA-directed-DNA-polymerase	RT	pfam00078_RT_CAS-I:CAS-III	gnl\|CDD\|239569
NC_014370.1\|WP_013263896.1\|12282_14802_+\|ribonucleoside-diphosphate-reductase-subunit-alpha	unknown	unknown	gnl\|CDD\|237077
NC_014370.1\|WP_013263801.1\|28173_28767_-\|aminotransferase-class-IV	unknown	unknown	gnl\|CDD\|235934
NC_014370.1\|WP_013264070.1\|25155_25650_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274357
NC_014370.1\|WP_013264725.1\|34279_34786_-\|5-(carboxyamino)imidazole-ribonucleotide-mutase	unknown	unknown	gnl\|CDD\|376377
NC_014370.1\|WP_013264581.1\|11300_11921_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_014370.1\|WP_013264971.1\|35572_37087_-\|RNA-polymerase-factor-sigma-54	gnl\|CDD\|274109	TIGR02395, RNA_polymerase_sigma-54_factor, RNA polymerase sigma-54 factor. A sigma factor is a DNA-binding protein protein that binds to the DNA-directed RNA polymerase core to produce the holoenzyme capable of initiating transcription at specific sites. Different sigma factors act in vegetative growth, heat shock, extracytoplasmic functions (ECF), etc. This model represents the clade of sigma factors called sigma-54, or RpoN (unrelated to sigma 70-type factors such as RpoD/SigA). RpoN is responsible for enhancer-dependent transcription, and its presence characteristically is associated with varied panels of activators, most of which are enhancer-binding proteins (but see Brahmachary, et al., ). RpoN may be responsible for transcription of nitrogen fixation genes, flagellins, pilins, etc., and synonyms for the gene symbol rpoN, such as ntrA, reflect these observations [Transcription, Transcription factors].	1.39097e-112
NC_014370.1\|WP_013264684.1\|19260_20103_+\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|234599	PRK00052, PRK00052, prolipoprotein diacylglyceryl transferase; Reviewed.	3.59555e-74
NC_014370.1\|WP_013264085.1\|21289_23950_+\|DNA-mismatch-repair-protein-MutS	gnl\|CDD\|235444	PRK05399, PRK05399, DNA mismatch repair protein MutS; Provisional.	0
NC_014370.1\|WP_013264633.1\|30663_31722_-\|sensor-histidine-kinase	gnl\|CDD\|377675	pfam06580, His_kinase, Histidine kinase. This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.	4.46464e-25
NC_014370.1\|WP_004358967.1\|15023_16070_+\|ribonucleotide-diphosphate-reductase-subunit-beta	gnl\|CDD\|236591	PRK09614, nrdF, ribonucleotide-diphosphate reductase subunit beta; Reviewed.	2.90118e-140
NC_014370.1\|WP_013264559.1\|16971_17781_+\|DUF3108-domain-containing-protein	gnl\|CDD\|378635	pfam11306, DUF3108, Protein of unknown function (DUF3108). This is a bacterial family of putative lipoproteins. Structure 3fzx, the first structural template for this large family including several homologs in the human gut microbiome and in metagenomic datasets, folds into a beta barrel that topologically looks like a small-scale porin (such as FepA). Bacteroides fragilis glyA is a putative exported protein, and this fold is of the YmcC-like type, with a predicted signal peptide SpI cleavage site AGAMA\|QNQDC, and a Phobius server prediction of non-cytoplasmic localization for amino acids 21-236. The possibility of it being a membrane protein can be ruled out by the hydrophilic nature of the solvent exposed surface outside the barrels. Analysis of sequence conservation suggests that an area near Glu172/Trp206 is potentially interesting. These two residues are also conserved in Dali hit Structure 2in5, a hypothetical lipoprotein classified as a new YmcC-like fold in SCOP (SCOP:159271, with a 12-stranded meander beta-sheet folded into a deformed beta-barrel) despite large structural differences between the two structures, suggesting similarity in function.	8.7468e-59
NC_014370.1\|WP_013264553.1\|28750_29740_-\|aminodeoxychorismate-synthase-component-I	gnl\|CDD\|235932	PRK07093, PRK07093, para-aminobenzoate synthase component I; Validated.	0
NC_014370.1\|WP_004358965.1\|18084_19188_+\|redox-regulated-ATPase-YchF	gnl\|CDD\|236583	PRK09601, PRK09601, redox-regulated ATPase YchF.	0
NC_014370.1\|WP_013265023.1\|29781_30423_-\|NAD(P)H-binding-protein	gnl\|CDD\|187560	cd05250, CC3_like_SDR_a, CC3(TIP30)-like, atypical (a) SDRs. Atypical SDRs in this subgroup include CC3 (also known as TIP30) which is implicated in tumor suppression. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine rich NAD(P)-binding motif that resembles the extended SDRs, and have an active site triad of the SDRs (YXXXK and upstream Ser), although the upstream Asn of the usual SDR active site is substituted with Asp. For CC3, the Tyr of the triad is displaced compared to the usual SDRs and the protein is monomeric, both these observations suggest that the usual SDR catalytic activity is not present. NADP appears to serve an important role as a ligand, and may be important in the interaction with other macromolecules. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.05939e-59
NC_014370.1\|WP_013264915.1\|32183_34112_-\|4-hydroxy-3-methylbut-2-en-1-yl-diphosphate-synthase	gnl\|CDD\|179361	PRK02048, PRK02048, 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional.	0
NC_014370.1\|WP_013264242.1\|26685_28011_+\|RNA-directed-DNA-polymerase	gnl\|CDD\|239569	cd03487, RT_Bac_retron_II, RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA branches out from a small ssRNA molecule via a 2'-5'phosphodiester linkage. Bacterial retron RTs produce cDNA corresponding to only a small portion of the retron genome.	1.84642e-72
NC_014370.1\|WP_013263896.1\|12282_14802_+\|ribonucleoside-diphosphate-reductase-subunit-alpha	gnl\|CDD\|237077	PRK12364, PRK12364, ribonucleoside-diphosphate reductase subunit alpha.	0
NC_014370.1\|WP_013263801.1\|28173_28767_-\|aminotransferase-class-IV	gnl\|CDD\|235934	PRK07101, PRK07101, hypothetical protein; Provisional.	1.50657e-72
NC_014370.1\|WP_013264070.1\|25155_25650_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	4.26965e-32
NC_014370.1\|WP_013264725.1\|34279_34786_-\|5-(carboxyamino)imidazole-ribonucleotide-mutase	gnl\|CDD\|376377	pfam00731, AIRC, AIR carboxylase. Members of this family catalyze the decarboxylation of 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR). This family catalyze the sixth step of de novo purine biosynthesis. Some members of this family contain two copies of this domain.	3.10683e-80

>NC_014370.1|WP_013264070.1|25155_25650_-|sigma-70-family-RNA-polymerase-sigma-factor
MDNLQNEQDFSRIVREHKSTIYTVCYMFSKDEDEVNDLFQEVLINLWKGLQNFRGESDVRTWIYRISLNTCISCDRKKRKRKTIPLSMNINPFTDSDDDSRQIQQLNRRISQLGPFDRAIILLWLENMSYEEIGEIVGISTKNVSVRLFRIKEKLKKTSETTKE
>NC_014370.1|WP_013264680.1|24411_25035_-|hypothetical-protein
METKHTEFEEMRQQLDILKNKLDNQTLINDKLIRQSMLNKMSFMKKYTWVSFLVLLFIYYVYNDIRITFNLSWWFYGATVIFMTFTVCFDAYINRFNKEAFLNGDLIATSLQMQRMKKLRKRSLLYGIFFMTIWVSWFVIELYNGSGAANGGENTSMFYGILVGGGVGLIAGVAIGIWLYLRMQRINSDIISQIDELTKDTKDSPIL
>NC_014370.1|WP_013264085.1|21289_23950_+|DNA-mismatch-repair-protein-MutS
MAKDDKGLTPMMKQFFSMKAQHPGALMLFRCGDFYETYGEDAVESARILGITLTRRNNGGNGDSIEMAGFPHHALDTYLPKLIRAGKRVAICDQLEDPKKKREAIKGKKGLSAMDKMVKRGITELVTPGVAMSDNVLNYKENNFLAAVHFGKGSCGVSFLDISTGEFLTGEGTFDYVEKLLGNFQPKEVLFDRAKKQDFERYFGTRLCTFEMDDWVFTDQTARQKLLKHFGTKNLKGFGVDHLNNGVVAAGAILQYLEITQHTQINHITSLARIEEDKYVRMDRFTIRSLELIAPMNEDGSSLLNVIDNTITPMGGRMLRRWMVFPLKDEKPINERLDVVDYLFREPDFRECINEQFHRIGDLERIISKVAVGRVSPREVVQLKNALMAIQPVKTVCLYTKSDTLKRIGEQLNLCESLRDRIEKEIQPDPPQLVNKGDVIALGFNQELDDLRSIRDNGKQYLLEIQEKEIAQTGITSLKIGFNNVFGYYLEVRNTFKDKVPENWIRKQTLAQAERYITPELKEYEEKILGADEKILALETQLYMELIQDMQEFIPQIQINANLIAHLDCLLSFMKVSQLQRYVRPVVDDSEVIDIKQGRHPVIETQLPIGEQYVPNDVLLDTEHQQIMMITGPNMAGKSALLRQTALIVLLAQIGCFVPAERARIGMVDKIFTRVGASDNISLGESTFMVEMTEASNILNNVTPRSLVLFDELGRGTSTYDGISIAWAIVEYLHEHSRAQARTLFATHYHELNEMEKNFPRIKNFNVSVKQVDGKIIFVRKLEKGGSEHSFGIHVAEIAGMPRSIVKRANVILKELEKDNSQVGSVGKAAVERLDQSREGVQLSFFQLDDPVLTQIRDEILGLDVNNLTPVEALNKLNDIKKIVKG
>NC_014370.1|WP_013264853.1|20709_21096_+|lipoprotein
MKKYLLILLALLPMMLFTACSSDKEEETSNNLVGTTWQYLEKEGNKITSMTVLEFKSNTVVKIITDEDLDKNPTERDHDEGDATYVLNGKKISIKRDIYTAWGEVDGDKLTLQYVDDGEIITMIFTKR
>NC_014370.1|WP_013264684.1|19260_20103_+|prolipoprotein-diacylglyceryl-transferase
MNNLLYIAWQPSEVIFQLGSLPIRWYGMCWLVGLALGYFMMQWLFKRHKFPPSQFDPLFLYVFFGVLIGARLGHCLFYEPEEFLTSWKGIMTIFIPIREMADGSWKYVGYQGLASHGGVAGLLIALFLYIRRTKMNTWVVLDFFGIVSGITACFIRLGNLMNSEIIGKVTDVPWAFIFYNVDDKPRHPGQLYEAIAYLIIFLLIYFIYRKYPKKVGTGLYFGLCLTLIFTFRFFIEYTKEIQEAFEAGLPIDMGQILSIPLIALGVWSILRSRGKEGKLP
>NC_014370.1|WP_004358965.1|18084_19188_+|redox-regulated-ATPase-YchF
MALKCGIVGLPNVGKSTLFNCLSSAKAQAANFPFCTIEPNLGVITVPDERLNKLAEIVHPGRIVPATCEIVDIAGLVKGASKGEGLGNKFLGNIRECDAIIHVIRCFEDDNVVREGGMAVNPIEDKEIIDTELQLKDLETIEAQLAKQQKVAAAGNKDAKVMVSVLEAYKEVLEQGKNARSVEFESKEEQQAAHDLFLLTTKPVLYVCNVDESSAKTGNEYSQMIEKIAAEEGAEAMIIAAKTEEDIASLESYEDKKMFLDELGLEESGVSRLINKAYHLLNLQTFITAGEMEVKAWTFHKGWKAPQCAGVIHTDFEKGFIRAEVIKYDDYIKYGSEAAIREAGKLGIEGKEYVVQDGDIMHFRFNV
>NC_014370.1|WP_013264559.1|16971_17781_+|DUF3108-domain-containing-protein
MKKFKIYIVCLFAMIAVSTTAQCTFRNTAFSSGEYLTYNLYYNWKFIWVKAGTASWYTVSSTYKGIPAYRASLTTRGNGKLDDYFVLRDTLLTYNSKQMEPLYFRKGAREGKRYTVDEIFYTYPNGKCKLRQHRINNEGKHQWMENTYDDCCFDMMSIFLRARSFNPENWKKGEVVKFPIVDGNSRHAGRIVYGGKENIKADNNHKYRCLRLTYYEYEDDKWREIANFYVTDDSNHIPVRLDMSLKFGSAKAFLVSMKGINSPITSEVK
>NC_014370.1|WP_004358967.1|15023_16070_+|ribonucleotide-diphosphate-reductase-subunit-beta
MDNQLKRNTLFNPSGDIELRLRRMIGGNTTNLNDFNNMKYSWVSDWYRQAMNNFWIPEEINLSQDFKDYPRLEKAERTAYDKILSFLVFLDSLQSNNLPTLSEYITANEVNLCLHIQAFQECIHSQSYSYMLDTICSPEERNDILYQWKTDEHLLNRNKFIGDCYNEFHEKRDKFSLMKTLIANFILEGIYFYSGFMFFYNLSRNGKMSGSAQEIRYINRDENTHLWLFRSIILELKKEEPDMFTPEKIKVYEDMMREGVRQEIAWGQYVIGNDVQGLNAQMVSDYIRYLGNLRWSGLGFGFLYDDNQKEPENMKWVGQYSNANMVKTDFFEAKSTAYAKSTALIDDL
>NC_014370.1|WP_013263896.1|12282_14802_+|ribonucleoside-diphosphate-reductase-subunit-alpha
MNITKRNGEVEVYNNEKISIAIKKSFISTGKDISDNEIAGMVSEVEQFIKENPELRTVEDIQNRVEKCLMAHGHYDEAKNYILFRYQRNEQRQAINYIVWTADDRELADVLHSVAREYRERSYSMVTLQEKFSSFTKPGMSQKDSIDALIKAAVELTTPEAPAWEMISARILSYRSEKKITRLEEELGLKTFYRKVKYMTEEGLYGDYILQNYSEEEINEAATFIDPERNKLLNYSGLDLLLKRYVIKNYSGKVIERVQEMFLGIALHLAMPEKEDRLMWVRRIYDLLSKLEVTMATPTLSNSRKPSHQLSSCFIDTVPDSLDGIYRSLDNFSQVSKFGGGMGMYFGKVRATGGNIRGFKGVAGGVIRWMRLVNDTAVAVDQLGMRQGAVAVYLDVWHKDLPEFLQLRTNNGDDRMKAHDIFPAICYPDLFWKMAEEDMNQNWSLFCPNEIMRIKGYCLEDCYGEEWERKYLDCVNDQRLSRRVISIKDIVRLVLRSAVETGTPFTFNRDTVNRANPNAHKGMIYCSNLCTEIAQNMAPIETVSKEVETKDGDTVVVTTTRPGEFVVCNLASLSLGRLPLEDEEKMKEKVATVVRALDNVINLNFYPVPYAQLTNQRYRSIGLGISGYHHALAKRRIKWESEEHLEFMDKVFETINRAAILASSNLAKEKGSYQFFEGSDWQTGTYFDKRGYDSAEWQDVRKTVALQGMRNAYLLAVAPTSSTSIIAGTTAGLDPIMKRFFLEEKKGSMLPRVAPELSDETYWMYKSAYLINQKWSVRASGVRQRHIDQAQSMNLYITNDFTMRQILDLYLLAWKEGVKTIYYVRSKSLEVEECESCSS
>NC_014370.1|WP_013264581.1|11300_11921_+|hypothetical-protein
MKQTALFFVFLLTLLSSCCTKTCQKTTESNALDSLVLVDTTEMKSAFLGCIHRFIKQYPKDSTFILKCGYGYEDHGVYTNGVYINSDVFVIQPAYYDMFMGGEWSIDDMYPSHYFKIDNRIVFLCSRSDSFMKQEKYRKAYSQIVSDSLRVHYEDFAFILVEHKDNKATLLSSEEMRKRKISPISGFRTVVKFKAPKLTDESSDDE
>NC_014370.1|WP_013264242.1|26685_28011_+|RNA-directed-DNA-polymerase
MATRTINGREYTKVDFENKLRHLSDAQELAAMLNELKLPWYYSDFRGKQLSFLADTNNVQRRCKTFRLRKKHGGYREITAPKGSLRGILNALNILLQTYDEPTPWAFGFVCGRSVVDNARPHVGKRYILNLDLKDFFPTITRQQVADCLTAEPFGFSSLAVKLISGLATVRTKNNKEVLAQGFATSPTLSNFICREMDKEIAGVAAAQGITFTRYADDLTFSSDTDILRPQGELVQQVKAIVERYGFRLNEEKTHLQRRGRRQEVTGLMVTEKVNVSRRYVREIRSLLYIWERYGYEDACQAAWKSYRQQHGKTKGHQHCVPLNAVLRGKLNYMKMVRGADDPLYQRFVSRYTSLQQRSKGDIKEVAYKAYMGKYLSNSTEDRMTSANVLPNDNTSSRQLGATSSNPYDPRKKSKRILNFIVMVIILVAIILIKLFLKSLL
>NC_014370.1|WP_013263801.1|28173_28767_-|aminotransferase-class-IV
MCQYIETIRVIDGCVCNLAYHEERLNRTRKEMLGLTEPLHIADLLKAVSLPMECSKLRFVYDKEGIHDITCTPYICKEINSLHLVYDNNISYPFKSTDRSALNELKKQQGDCDEILIVRDNHLTDTSYTNIALYDGEQWFTPSTPLLCGTMRQRLLDCGLLQEREIMVSDIPNYQYISLFNAMISLGEVILPVDKIK
>NC_014370.1|WP_013264553.1|28750_29740_-|aminodeoxychorismate-synthase-component-I
MILYDREHAIQRMNTLAKEGKDFIFIINYKADGAYIEEVADINPHELLFAFPSLSNIPEGESYSNEAVEWHTEPLTRDDYEQRINLVKQREREGDSYLANLTCKIPVRTNLSLHDIFMRSKALYRCWMKEKFVCFSPEIFVRINKEGLISSFPMKGTIDATRPEAEKELMENKKEAAEHATIVDLIRNDLSIIAEQVQVKRYRYIDHLTTNKGEILQTSSEITGQLPTDYRENIGTLLFHLLPAGSITGAPKPRTMEIIDEAEGYERDFYTGVMGCYSKGQLDSAVMIRFIDQDKDGQLHYKAGGGITAQSNNDDEYKEVIEKVYVPIY
>NC_014370.1|WP_013265023.1|29781_30423_-|NAD(P)H-binding-protein
MRAIILGATGAIGKDLVQELINDDTIEQIAIFVRRDPGINNEKVTTHIVDFDQSDEWRLSVQGDVVFSCMGTTRKAAGSKENQYKIDYTYQYNFAKIAAEQGVPSFILVSAAMANANSHFFYTKMKGELEEAIKQLPFQHISILRPPALIRKNTTRSSEKLSVSILHFFNKIGLLQSQRPMKTEVVAHCMVELAKTKKSGVFEPKDIFKIGER
>NC_014370.1|WP_013264633.1|30663_31722_-|sensor-histidine-kinase
MKVLEDIKKYCLSRYNLSVLGAQVGIYALLVSIWSLVIMLLEHDVNAAKESMCVNAFVLFLLLIVFMANFYVLVPYLFEAKNKIKHWAFWVINLLFIVLWNHHIFSIYNADLPNAPIRIGFYQFGVMWMILNYAMVVAAIFVRYYIRHSTLRRQLREEKQKMTEAELAWLKNQLNPHFLFNTLNNIASLTQTSPNNAQKAIGQLSELLRYALYETQPKEVSLNGEIAFIKNYINLMTLRSGSNVEIKSQFIIHNTQLLIAPLVFLTPVENAFKHGISANKPSFIHISITEDNGKIVFLCENSNYPKNDTDKSGKGIGLENMYRRLELIYPDRYHIEQRITPEVYHLKIIIKP
>NC_014370.1|WP_013264915.1|32183_34112_-|4-hydroxy-3-methylbut-2-en-1-yl-diphosphate-synthase
MIDLFNFERRKTSVTHVGALNIGGENPVRVQSMTTTSTDDTEGSVAQAKRIIDAGGELVRLTTQGKREAENLKNINAQLRADNYMAPLCADVHFNANVADVAALYAEKVRINPGNYVDPARTFKKLEYTDEEYAQELQKIEDRLIPFINICKENHTAVRIGVNHGSLSDRIRNRYGDTPEGIVESCMEFLRIFRKYDFHDIVISIKSSNTVVMVRSVRLLVAEMDKEGMHYPLHLGVTEAGEGEDGRIKSAVGIGALLADGIGDTIRVSLSEEPECEIPVAKHLTWYIRRHEKHHLIPAEQYDGFDYLHPNRRETVAAGNIGGENVPVVIATRKADQATAEVSSPELPKPDYIYVQGELPEKRAKKQKYILDYDAYMNLANSGKQSLENVYPIFPVTGMPFISAINSDVKFLVLKFGTPSEEFLACLKAHPEVVVVCMTSHQNRLGDQRALAHQLMIAGVKNPIIFAQMYQHSTTEEKEESSNSQQAETTTAKEKFQLEAAADMGALMMDGLTDGIWLMNNGNLSQEDVEQTAFGILQAGRLRMVKTEYISCPGCGRTLYDLRTTIARIKEATKGMKGLKVGIMGCIVNGPGEMADADYGYVGAGPKKVSLYRKQVCVEHNIPEEEAVERLLALIKADQNKA
>NC_014370.1|WP_013264725.1|34279_34786_-|5-(carboxyamino)imidazole-ribonucleotide-mutase
MKPLVSIIMGSTSDLPVMEKACKWLEEQEIPFEVNALSAHRTPDAVETFAKEAKGRGVKVIIAAAGMAAALPGVIAASTPLPVIGVPIKGMLDGLDALLSIVQMPPGIPVATVGVNGAQNAAILAAEMIALGDEAIAKKIDNWKASLGQKIEKANKELAELKDYKFKC
>NC_014370.1|WP_004358931.1|34914_35532_-|hypothetical-protein
MNEKNIILTARVVSMVLTPFYLPVVGILAIFTFSYLSMFPWQAKLSYVFLVYAFTVLIPTLLIHLYRQYHGWTLIQLGQRERRMVPYVISILCYFTCFYIMNILHLPHMLTSILMVALIIQILCAIINVWWKISTHTAAIGGVTGSLIAFSLLFNFNPMWWLCLTLIVSGFVGSSRMILRQHSLEQVASGFFLGIICSFITIIVV
>NC_014370.1|WP_013264971.1|35572_37087_-|RNA-polymerase-factor-sigma-54
MAQEQVQIQTQKQQQVQRLSQQQMLQVKLLEMPLTELEESVNAELDDNPALEAGGEETDSIDDNDTVEHSEDDDFDTLQEREERQDALDSALERMRSDDDLPTYDSRQQRNNAEYEEIVYGDTTSFIDKLNEQVGERELTERQKSILEYLIGSLDDDGLLRKDLDSISDELAIYYGIDASTKELEEVLKILQDFDPAGIGARDLQECLLLQIDRKVENGEWEKDSHLYKYIYNILSHHFDAFKKKHWDKIQSALSLSDLQVEALQREIRKLNPKPGSSMGETQGRNLQQITPDFIIDTEDDGTVTFSLNHGNLPELHVSQTFNDMMETYRNNKANMNRQEKEALLYAKEKVEKAQGFIEAVKQRRHTLQVTMKAIIDIQRKFFQDGDEADLKPMILKDIADRTGLDISTISRVSNIKYAQTRWGTFPLRFFFTDSYTTEDGEEMSTRKIKLALKEVIDKEDKRKPLSDDALAKVMKEKGFPIARRTVAKYREQLGLPVARLRKE
>NC_014370.1|WP_013264010.1|37133_37784_-|hypothetical-protein
MATHPLWSDDYWLLLLQLYLKKPEGMKPMYSRALVDLSLELHIPPKNLYEQLFKLRHRDMPIINLIWETYGENTRKLNKDVKKLRSMKGFGQPKKFYDGVKVRETFEHDFLPVEGGATELKPFMLIMILDLYFRLTPITMAAETPEVIDLAKLMKIKPQMIVEVMDVFQLCDPYLNRDDLLISPLLMPCQEVWNRYGNDNPEKLSALAAQLKEYFT

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Crispr_ID: NC_014370_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014370_2

1232798-1232914

Orphan

Consensus_repeat	Method
TTTGAATCCCAACGGAGTCACAAAAAGTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014370_2

>merge|NC_014370|2|1232798-1232914|CRISPRCasFinder
TTTGAATCCCAACGGAGTCACAAAAAGTGACAACTTTCTGATGACATTTAGCTGAATGAGGTTAGAAAAATGTTCTGAAGGTCTTGGATTTGAATCCCAACGGAGTCACGAAAAAGT

>NC_014370|2|2|1232798-1232914|CRISPRCasFinder
TTTGAATCCCAACGGAGTCACAAAAAGTG	ACAACTTTCTGATGACATTTAGCTGAATGAGGTTAGAAAAATGTTCTGAAGGTCTTGGA
TTTGAATCCCAACGGAGTCACGAAAAAGT

Protein	Signature genes	Signature genes Name	Protein_function
NC_014370.1\|WP_013264276.1\|1243867_1244689_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224495
NC_014370.1\|WP_013264783.1\|1241883_1242804_+\|hypothetical-protein	unknown	unknown	unknown
NC_014370.1\|WP_013264667.1\|1224890_1225637_+\|peptidylprolyl-isomerase	unknown	unknown	gnl\|CDD\|365914
NC_014370.1\|WP_036924459.1\|1226529_1226808_-\|CD225/dispanin-family-protein	unknown	unknown	gnl\|CDD\|377375
NC_014370.1\|WP_013263980.1\|1227759_1228827_+\|agmatine-deiminase-family-protein	unknown	unknown	gnl\|CDD\|377332
NC_014370.1\|WP_013264664.1\|1223405_1223855_+\|type-I-restriction-enzyme-HsdR-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|372640
NC_014370.1\|WP_013264651.1\|1233160_1234348_+\|dicarboxylate/amino-acid:cation-symporter	unknown	unknown	gnl\|CDD\|366058
NC_014370.1\|WP_044045886.1\|1230340_1230727_+\|hypothetical-protein	unknown	unknown	unknown
NC_014370.1\|WP_013264961.1\|1236113_1238384_+\|cation:proton-antiporter	unknown	unknown	gnl\|CDD\|223551
NC_014370.1\|WP_013264320.1\|1238826_1241541_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|350195
NC_014370.1\|WP_044045887.1\|1242890_1243706_+\|Nif3-like-dinuclear-metal-center-hexameric-protein	unknown	unknown	gnl\|CDD\|376614
NC_014370.1\|WP_013264295.1\|1245098_1245614_-\|nitroreductase	unknown	unknown	gnl\|CDD\|380313
NC_014370.1\|WP_013264855.1\|1231425_1232463_-\|aspartate--ammonia-ligase	unknown	unknown	gnl\|CDD\|235456
NC_014370.1\|WP_013263813.1\|1223993_1224803_+\|TerB-family-tellurite-resistance-protein	unknown	unknown	gnl\|CDD\|236512
NC_014370.1\|WP_044045885.1\|1225742_1226084_-\|TM2-domain-containing-protein	unknown	unknown	gnl\|CDD\|377473
NC_014370.1\|WP_013264078.1\|1245626_1246808_-\|putative-C-S-lyase	unknown	unknown	gnl\|CDD\|275146
NC_014370.1\|WP_013264962.1\|1228914_1229799_+\|carbon-nitrogen-hydrolase	unknown	unknown	gnl\|CDD\|143597
NC_014370.1\|WP_050759749.1\|1226144_1226513_-\|DUF2752-domain-containing-protein	unknown	unknown	gnl\|CDD\|378499
NC_014370.1\|WP_004360103.1\|1234672_1235896_+\|peptidase-T	unknown	unknown	gnl\|CDD\|235484
NC_014370.1\|WP_013264805.1\|1246804_1247980_-\|PLP-dependent-transferase	unknown	unknown	gnl\|CDD\|223699

Protein	Function_ID	Function_description	E-value
NC_014370.1\|WP_013264276.1\|1243867_1244689_+\|hypothetical-protein	gnl\|CDD\|224495	COG1579, COG1579, Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only].	2.60232e-21
NC_014370.1\|WP_013264078.1\|1245626_1246808_-\|putative-C-S-lyase	gnl\|CDD\|275146	TIGR04350, aminotransferase_class_I_and_II, putative C-S lyase. Members of this subfamily are probable C-S lyases from a family of pyridoxal phosphate-dependent enzymes that tend to be (mis)annotated as probable aminotransferases. One member is PatB of Bacillus subtilis, a proven C-S-lyase. Another is the virulence factor cystalysin from Treponema denticola, whose hemolysin activity may stem from H2S production. Members of the seed alignment occur next to examples of the enzyme 5-histidylcysteine sulfoxide synthase, from ovothiol A biosynthesis, and would be expected to perform a C-S cleavage of 5-histidylcysteine sulfoxide to leave 1-methyl-4-mercaptohistidine (ovothiol A).	7.98929e-164
NC_014370.1\|WP_013264667.1\|1224890_1225637_+\|peptidylprolyl-isomerase	gnl\|CDD\|365914	pfam00160, Pro_isomerase, Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD. The peptidyl-prolyl cis-trans isomerases, also known as cyclophilins, share this domain of about 109 amino acids. Cyclophilins have been found in all organisms studied so far and catalyze peptidyl-prolyl isomerisation during which the peptide bond preceding proline (the peptidyl-prolyl bond) is stabilized in the cis conformation. Mammalian cyclophilin A (CypA) is a major cellular target for the immunosuppressive drug cyclosporin A (CsA). Other roles for cyclophilins may include chaperone and cell signalling function.	7.38672e-41
NC_014370.1\|WP_036924459.1\|1226529_1226808_-\|CD225/dispanin-family-protein	gnl\|CDD\|377375	pfam04505, CD225, Interferon-induced transmembrane protein. This family includes the human leukocyte antigen CD225, which is an interferon inducible transmembrane protein, and is associated with interferon induced cell growth suppression.	9.04683e-23
NC_014370.1\|WP_013263980.1\|1227759_1228827_+\|agmatine-deiminase-family-protein	gnl\|CDD\|377332	pfam04371, PAD_porph, Porphyromonas-type peptidyl-arginine deiminase. Peptidyl-arginine deiminase (PAD) enzymes catalyze the deimination of the guanidino group from carboxy-terminal arginine residues of various peptides to produce ammonia. PAD from Porphyromonas gingivalis (PPAD) appears to be evolutionarily unrelated to mammalian PAD (pfam03068), which is a metalloenzyme. PPAD is thought to belong to the same superfamily as aminotransferase and arginine deiminase, and to form an alpha/beta propeller structure. This family has previously been named PPADH (Porphyromonas peptidyl-arginine deiminase homologs). The predicted catalytic residues in PPAD are Asp130, Asp187, His236, Asp238 and Cys351. These are absolutely conserved with the exception of Asp187 which is absent in two family members. PPAD is also able to catalyze the deimination of free L-arginine, but has primarily peptidyl-arginine specificity. It may have a FMN cofactor.	4.36664e-164
NC_014370.1\|WP_013264664.1\|1223405_1223855_+\|type-I-restriction-enzyme-HsdR-N-terminal-domain-containing-protein	gnl\|CDD\|372640	pfam13588, HSDR_N_2, Type I restriction enzyme R protein N-terminus (HSDR_N). This family consists of a number of N terminal regions found in type I restriction enzyme R (HSDR) proteins. Restriction and modification (R/M) systems are found in a wide variety of prokaryotes and are thought to protect the host bacterium from the uptake of foreign DNA. Type I restriction and modification systems are encoded by three genes: hsdR, hsdM, and hsdS. The three polypeptides, HsdR, HsdM, and HsdS, often assemble to give an enzyme (R2M2S1) that modifies hemimethylated DNA and restricts unmethylated DNA.	4.58584e-51
NC_014370.1\|WP_013264651.1\|1233160_1234348_+\|dicarboxylate/amino-acid:cation-symporter	gnl\|CDD\|366058	pfam00375, SDF, Sodium:dicarboxylate symporter family.	1.45475e-73
NC_014370.1\|WP_013264961.1\|1236113_1238384_+\|cation:proton-antiporter	gnl\|CDD\|223551	COG0475, KefB, Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism].	2.23756e-57
NC_014370.1\|WP_013264320.1\|1238826_1241541_-\|AAA-family-ATPase	gnl\|CDD\|350195	cd18808, SF1_C_Upf1, C-terminal helicase domain of Upf1-like family helicases. The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), and similar proteins. They are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.	8.12364e-38
NC_014370.1\|WP_044045887.1\|1242890_1243706_+\|Nif3-like-dinuclear-metal-center-hexameric-protein	gnl\|CDD\|376614	pfam01784, NIF3, NIF3 (NGG1p interacting factor 3). This family contains several NIF3 (NGG1p interacting factor 3) protein homologs. NIF3 interacts with the yeast transcriptional coactivator NGG1p which is part of the ADA complex, the exact function of this interaction is unknown.	8.36983e-87
NC_014370.1\|WP_013264295.1\|1245098_1245614_-\|nitroreductase	gnl\|CDD\|380313	cd02136, PnbA_NfnB-like, nitroreductase similar to Mycobacterium smegmatis NfnB. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source of reducing equivalents in an obligatory two-election transfer mechanism. The enzyme is typically a homodimer. Mycobacterium smegmatis nitroreductase NfnB plays a role in resistance to benzothiazinone.	4.46706e-40
NC_014370.1\|WP_013264855.1\|1231425_1232463_-\|aspartate--ammonia-ligase	gnl\|CDD\|235456	PRK05425, PRK05425, asparagine synthetase AsnA; Provisional.	0
NC_014370.1\|WP_013263813.1\|1223993_1224803_+\|TerB-family-tellurite-resistance-protein	gnl\|CDD\|236512	PRK09430, djlA, co-chaperone DjlA.	3.87307e-25
NC_014370.1\|WP_013264962.1\|1228914_1229799_+\|carbon-nitrogen-hydrolase	gnl\|CDD\|143597	cd07573, CPA, N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases). CPA (EC 3.5.1.53, also known as N-carbamoylputrescine amidase and carbamoylputrescine hydrolase) converts N-carbamoylputrescine to putrescine, a step in polyamine biosynthesis in plants and bacteria. This subgroup includes Arabidopsis thaliana CPA, also known as nitrilase-like 1 (NLP1), and Pseudomonas aeruginosa AguB. This subgroup belongs to a larger nitrilase superfamily comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), this subgroup corresponds to class 11. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer; P. aeruginosa AugB is a homohexamer, Arabidopsis thaliana NLP1 is a homooctomer.	7.34524e-172
NC_014370.1\|WP_044045885.1\|1225742_1226084_-\|TM2-domain-containing-protein	gnl\|CDD\|377473	pfam05154, TM2, TM2 domain. This family is composed of a pair of transmembrane alpha helices connected by a short linker. The function of this domain is unknown, however it occurs in a wide range or protein contexts.	1.39818e-15
NC_014370.1\|WP_050759749.1\|1226144_1226513_-\|DUF2752-domain-containing-protein	gnl\|CDD\|378499	pfam10825, DUF2752, Protein of unknown function (DUF2752). This family is conserved in bacteria. Many members are annotated as being putative membrane proteins.	1.08995e-12
NC_014370.1\|WP_004360103.1\|1234672_1235896_+\|peptidase-T	gnl\|CDD\|235484	PRK05469, PRK05469, tripeptide aminopeptidase PepT.	0
NC_014370.1\|WP_013264805.1\|1246804_1247980_-\|PLP-dependent-transferase	gnl\|CDD\|223699	COG0626, MetC, Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism].	4.50441e-117

>NC_014370.1|WP_013264855.1|1231425_1232463_-|aspartate--ammonia-ligase
MSQLIKPEGYKAVLGKRQTEQGIKLIKEFFQQNLATELRLSRVTAPLFVLKGLGINDDLNGVERPVSFPIKDLGEAEAEVVHSLAKWKRLTLADYDIQPGYGVYTDMNAIRADEELDNLHSLYVDQWDWEAVITEGDRTRSFLENVVRRIYAAILRTEFLTCETYPQLEPFLPQTIHFIHAQDLLDMYPTMTAKEREDEVCKKYGAVFIEGIGCRLSNGEKHDGRAADYDDWSTVAEDGKTGLNGDILIWYPILDRSIELSSMGVRVDKTALLRQLTIEKQEERQQLFFHQQLLSDKLPLCIGGGIGQSRLCMIMLHKAHIGEIQASIWPEEMRRECEEAGMPLI
>NC_014370.1|WP_044045886.1|1230340_1230727_+|hypothetical-protein
MRMKMLILIGFITVSCTSVPNKKCIVQKNQVRVIKTEKSTAFKYLQGIWIIPHAADIRIVFKNDSTFEFHDYNSIKDSIEILKGIYVLNNDQLTLRYTDRPQQKFIYHFGRYEDERYIRKGKYYFVKQ
>NC_014370.1|WP_013264962.1|1228914_1229799_+|carbon-nitrogen-hydrolase
MRELKIGFLQQHNVEDIKNNIERLAEGITNLAQRGAELVILQELHNSLYFCQTEDVNKFDLAETIPGPSTGFYGELARELGIVIVTSLFEKRAPGLYHNTAVVIEKDGSIAGKYRKMHIPDDPAYYEKFYFTPGDLGFHPIDTSVGRLGVLVCWDQWYPEAARLMALQGADMLIYPTAIGYESSDTDEEKQRQREAWTTVMRGHAVANGLPVIAVNRVGHEPDPSEQTQGIQFWGSSFVAGPQGELLYRACDNDEDSVILSINLDHSENVRRWWPFLRDRRIDEYGEITKRFID
>NC_014370.1|WP_013263980.1|1227759_1228827_+|agmatine-deiminase-family-protein
MNTNENHSFRLPAEWEPQSGVILIWPHEDTDWRPYLEEITEVYLQMADAITRYEALLITARETEMVSSLLKGRLTEEQMKRVTLFTCDNNDTWARDVAPISLIANKASKDSFHPLRLLDFCFNGWGEKFAAEKDNRINRQLHEAGLLQGVLENHKDFVLEGGSIESDGSHTLFTTTSCLMAPHRNQPLTQEDIDKQLRLFFPNVERVIWLDYGQLAGDDTDGHIDTIVRIAPNDTLLYIGCDDKEDEHYEDFQLLEEQLKQLRTQKGEPYRLLRLPMPDAIYDDDERLPATHANFLIINGAVLVPTYNQPEKDKEALDTIQEAFPDREIIGIDSRTIIRQHGSIHCLTMQLPANG
>NC_014370.1|WP_036924459.1|1226529_1226808_-|CD225/dispanin-family-protein
MEEMNTPKPNNNLALAIFTTVCCCLPAGIYAIIRAMKVNELYMMKQYDEAVLAANDAKKWSIIGIVVGLIGSILYFVCFGGLAALSTMAGSH
>NC_014370.1|WP_050759749.1|1226144_1226513_-|DUF2752-domain-containing-protein
MKCIGWLCLGASLLILYYFYNPVTTLWAPKCLLKVATGLQCPGCGIQRALHALLQGRFSEAIHYNYFLLFSGPYILSFGVRALLPKGKAKDSLTKVIEDKRLIWLYIILFFIWFIVRNILKI
>NC_014370.1|WP_044045885.1|1225742_1226084_-|TM2-domain-containing-protein
MESEKVNHMLMMLSSKIPAGSIPSVRTRLENTDISESEILALQSQMKDPLLSILLSIFIGTLGVDRFYIGDVGLGIGKLLTGGGCGIWWLIDIFLIVDATKQKNLELLSYYLR
>NC_014370.1|WP_013264667.1|1224890_1225637_+|peptidylprolyl-isomerase
MATRLKIKTTEGDIIIRLYDETPKHRDNFLKLAKEGYFNGTLFHRVIKDFMIQGGDPDSKNAPKGKMLGTGGPDYTIPAEFVYPQYFHKRGALSAARTGDEVNPEKESSGSQFYIVWGKTFKPAELKQMEHQMAMQQEQQVFNQLTREHHEEIMNLRRNRDRVGLQELQDKLIEQTKTTCKQQGKPSFTEEQIEVYTNVGGTPFLDNQYTVFGEVEEGLGIVERIQNCDTDRNDRPTEDVKIETVALL
>NC_014370.1|WP_013263813.1|1223993_1224803_+|TerB-family-tellurite-resistance-protein
MAIGKWIGGALGWILSGSMLGGLVGYCIGTMLDEAFAGDNRGGDRQNGYGEQSHFGGTRPFEEDRNSFLFSMLVLSSYIIKADGKIMHSEMEYVRQFLRHNFGEQAVSQGESILLKLFDLQKQQGPYQFKETIRKSCVEIHFHTSVSQRLQLLNYLVIIAKADGIVSPEEVVALKEIASYLGLSAQDIESMLNLESGAKASSNIEDAYKVLGISPSATDDEVKAAYRKMALKHHPDRVSTLGDDIRKAAEKKFQEINDAKERIYKARGL
>NC_014370.1|WP_013264664.1|1223405_1223855_+|type-I-restriction-enzyme-HsdR-N-terminal-domain-containing-protein
MMQLNLPPYQIRVREENGRKQIFDVLRRKYIALTPEEWVRQHFIHYLIEHKSYPVTLLANEVPLQVGEKKVRADSVLYDNQLRPRMIIEYKAPTIPLTQKVFEQISVYNLLLHVDYLIVSNGLDTYICKMDYENQTYAFLETIPDYQNI
>NC_014370.1|WP_013264651.1|1233160_1234348_+|dicarboxylate/amino-acid:cation-symporter
MQKKIKIGLLPRVIIAILLGLFLGYYLPDPAVRVFLTFNSIFSQFLGFMIPLIIIGLVTPAIAGIGKGAGKLLLATVAIAYVDTIVAGGLSYGTGTWLFPSMIASTGGAIPHIDKATELTPYFTINIPAMVDVMSSLVFSFIAGLGIAYGGLRTMETLFNEFKTVIEKVIEKAIIPLLPLYIFGVFLSMTHNGQARQVLLVFSQIIIVILVLHVLILIYEFCIAGAIVKHNPFRLLWNMLPAYLTALGTSSSAATIPVTLKQTVKNGVSEEVAGFVVPLCATIHLSGSAMKITACALTICMLTDLPHDPGLFIYFILMLAIIMVAAPGVPGGAIMAALAPLSSILGFNEEAQALMIALYIAMDSFGTACNVTGDGAIALAVNKFFGKKKETTVLS
>NC_014370.1|WP_004360103.1|1234672_1235896_+|peptidase-T
MEIVERFINYTKFDTQSAEDSETVPSTPKQLIFAKYLKEELEREGLKDVEMDEMGYIYATLPANTKKKIPTIGFISHYDTALDASGANVNARIVENYDGGDIQLNPNMVSSPRMFPELLEHKGEDLIVTDGTTLLGADDKAGIAEIVQAMCFLRDHDEIEHGDIRIAFNPDEEIGMGAHHFDVEKFGCEWGYTIDGGDLGELEYENFNAAGAKVFIHGVSVHTGYAKGKMVNASRLACEFNNMIPETEIPEETEGYQGFYHLIGIESRCEEAKLSYIIRDHDREHFEDRKRFMENCVKKMNEKYGEGTVELKMNDQYYNMKEKIDPNMHVIELVLQAMQQANVAPKVQPIRGGTDGAQLSFKGLPCPNIFAGGVNFHGPYEFVSVQVMEKAMQVIINICRLTAEFND
>NC_014370.1|WP_013264961.1|1236113_1238384_+|cation:proton-antiporter
MSELPELVQDLALILVVAGFVTLLFKKLKQPLVLGYIVAGFLVSPHMSYTMSVVDKDDIQTWADIGVIFLLFSLGLDFSIKKILKMGASPIIAACTIIFSMMLLGVIVGHSFGWKEMDCIFLGGMVAMSSTTIIYKAFSDMGLTQQGFASTVMSVLILEDILAIVMMVMLSTVASGNSPDGVQLLGSIMKIGFFLVLWFVVGLFAIPLFLRSVRKILNSETLLIVSLGFCCLMAVISTQVGFSAAFGAFVMGSILAETVEADKIIRLVDPVKNLFGAIFFVSVGMLVKPDVIVQYAIPILLLVITILVGQALFGTLGYLLGGQTLKNAMRCGFSMAQVGEFAFIIATLGKSLGVISEFLYPVVVAVSVITTFLTPYMIRAAEPCYNILIKHLPKRWVRRLTHIQTNSAGESASSDNHWKVLMKKMILNTLIYGILSAAVIAIMFSAALPICRNLSIKWTGSHWIGNAVCGFLTILFIAPFLRSIVMKQNHSEAFKALWTDRRINRLPLTATILARVLIALSFIFYICNYLTRFKNALMIAVAVGLLILMLLSRWLKKRSITLERLFIQNLQSRDIEAQKQGKKKPLFANHLIDRDIHIANLELPDDSLWAGKTLYSLKLRNRFGVHISSILRGSKHINIPNGGTILFPGDKLQAIGNDEQLTKLSKAMKAELQPTITDIEKHEMKLRSFTISKTSPFIGKTLKDSGIRDEYNCMVVGVDEGQKNLTLITPSRSLQAGDVLWVVGEEKDLERILALG
>NC_014370.1|WP_013264320.1|1238826_1241541_-|AAA-family-ATPase
MDAKQCMIVDLERRGDKQMFITDQVDFIKKADNGNWMIRFLKSPRIFQYNQARILYFTHGEPVNLHEKGLYIGNKHITSAVELLRFSNKHYTFYYVTYSNGYSENLDGNNVYVTRTPIDMCGGSTWDYLRKLADETGLLAEDEESILSKQYDLIDLKRDNVPLAQYLGDKTKLATYRLPQLVYYPFGCNASQKKAVEAALTHQASIIQGPPGTGKTQTILNIVSNLLVQKKTVLVVSNNNSAVENVAEKLEKEGLGFLVAQLGSVKNKEAFVESQSGCYPNMEEWYLDNSKEVRKIAKDSLAAVSLGFDGQTRLAQLKAEYDALVTEKKYDEKLKMASGFDNDWLSEKHSSKIMKLLNLCKIMQEHGKTPSLLFCFKWVFLLGPRAYSLLKNNLLIVIEQLESAYYLTRKFEIEQEVDSIEQQLLSVDVKESAEELRKSSLQVLKQAIAKQYGSGRRTLFTRQDIKPRTETFLKEYPIVLSTTYSAKSCISKDFVFDYMIMDEASQVDIKTGALALSCAANVVIVGDDMQLPNVVSSEEEKALNAIRTTYNVDDRYNAVTHSFLRSCTEILKDAPTTLLREHYRCHPKIIQFCNQRFYGGELLPMTIDKGEEDVLQVIQTVKGNHAREHFNQREIDVIVQEVMPLCAGKGSVGIITPYRTQAEAINRVLGKDIASTVHKYQGRECDTIIMSMVDNLPTSFSDDKNLLNVAISRAKSQLYIVTSGNEMAQDTNLAQLISYVKYNNFAVKNSKIHSVFDLLYQQYTTERLAYQSEHIMVSDYMSENLVYNLIVKVLEELSWKNLAVVCHYPLAKIISDWSLLSNQENDFAKNSLTHIDFLIYNSLTKQPLMAIEVDGWLYHKDKVVQQSRDRLKDQILTKYSLIPYRISTTDTITAESLKEVFVSL
>NC_014370.1|WP_013264783.1|1241883_1242804_+|hypothetical-protein
MIIQMKRNKLTALIALIGIVAFTSCEDVKRPTPVRERINVTPPSREAEAISQLTASIDEISANLDAISSQEAMLCKTTEHANKKSKIIQQIRGLGALLKEKQNQIDKLLNEKVKKVDAPAVSNPTIDNLYKVIDFLSSQLKEKGDRVTQLEQVASRKDVTVDQLKYIVMNQTNSVDAMRYRFNMAALEREYAQLKAKEKQRIKEDKESDKVYYIIANKETLKEKGLLKTSLFSKKVNNNNVTKDLFTEANGKDLKTLTINSSSPKLLSQNPEGSYTLTENEDGTTTLTITDAEKFWNVSRYLIIQE
>NC_014370.1|WP_044045887.1|1242890_1243706_+|Nif3-like-dinuclear-metal-center-hexameric-protein
MRSVKIKEVIDALERFAPLPLQESYDNAGLQVGLTEAEVSGALLCLDVTEKVVDEAIRRECNLIVAHHPLIFRKLAQVTDANYVQRTVIKAIKNDIVIAAMHTNLDSAVGGVNYKIAEKLGLKDLRFFGRSKQVVNPQTGESVTGGDGVIGEFEEPLAADDLILLLKKKFDAECVQTNELLRREIRTIALCGGSGAFLLQDAIAAGADAFMTGEMSYHEFFGHEQEIQICVIGHYQSEQFTIEVLRDVIERECPSVKCYLSEINTNPIGYF
>NC_014370.1|WP_013264276.1|1243867_1244689_+|hypothetical-protein
MAKKDPKELPVEEKLKALFQLQTTLSGIDEKRALRGELPLEVRDLEDELEGLHIRIEKIEQDIKDYQNAITQKKGNIVDAQASLERYNKQLDSVANNREYDTLTKEIEFQTLEIELCNKKIKEAQIKVEEKRKDLEANRALLEDRQHALEEKRNELDEIMQETREEEGLLKEKAAELETKIEPGLLRSFKRIRRGARNGLGIVYVQRDACGGCFNKIPPQRQLDVKMHKKIIVCEYCGRILIDPELAGVKVDKTEEKPKKRRATRKKKEEEGE
>NC_014370.1|WP_013264295.1|1245098_1245614_-|nitroreductase
MEALEALLTRRSVRAYEERMPEQDLIAKVMEAGLYAASGKNMQTAIIVEVTNKEVRDRLSAINAEIMGVTSDPFYGAPVVLAVLADKSSPNHVYDGALMMGNLMNAAHALGLGSCWINRAKQTFEREDGKQMLKEWGIKGDYEGVGFCILGYAAKEGKTAPRKANRIFYVK
>NC_014370.1|WP_013264078.1|1245626_1246808_-|putative-C-S-lyase
MMKTYNFDEIIDRSGSGDLKHEALLPRWGRNDLLPLWVADMDFACPDFVVEALKDRLSHPIFGYTVEPEDFRPAIIDWIRAHHDWEVKPEWLSFIPGIVRGIGFVVNVFTELDEKVIIQPPVYHPFRLTPEANHRKVVFNPLRLREDGYYDMDFDNLAEVCDDKCRVLILSNPHNPAGLCWSEDTLRRLADFCYEHNIIVISDEIHSDMALFGNRHIPFASVSERAAQISITFAAPTKTFNMAGIVSSFAIVPNEELRNRFYGWLKANELDEPTLFAPIATIAAYRKGEEWRKQMLAYVEENVRFVEDFCREYIPGIRPLRPQASFLVWLDCHGLGLKHKELLNLFIDKAHLALNDGRMFGPGGEGFMRLNVGTPRSILRQALEQLAEAVNEL
>NC_014370.1|WP_013264805.1|1246804_1247980_-|PLP-dependent-transferase
MKKQTQAIHQPYKRRDAYDALSMPIYNAVAFEFDNAKVMADAFCGRIDAPDYSRVENPTVTNLEQRVKALTGAENVIALNSGMAAISNTLFSVVEQGKNVITSRHLFGNTYSLLTSTLSRLGVEARLCDLTDVEAVERLIDDNTCCLFLEIMTNPQLEVVDVRALTSIAHQHGIPVIADTTLIPFTQFSAKDLGIDLEVVSSTKYISGGATSLGGLVIDYGTFPSIGKRLLNEMLFNLGAYMTPQVAYMQTLGLETLDVRYRAQAGNALELAQRLRTLKPIHKVNYVGLEDNPYHQLAVSQYGETAGAMVTIDLESQEACFRMLDNLKLIHRATNLFDNRTLAIHPASTIFGLFTAEERAAMDVQDTTIRLSIGLESVDDLFDDIKQALEA

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Crispr_ID: NC_014370_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014370_3

1464193-1464289

Orphan

Consensus_repeat	Method
TGCAAAGATAGTGCAAATGAGAACAAAAGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014370_3

>merge|NC_014370|3|1464193-1464289|CRISPRCasFinder
TGCAAAGATAGTGCAAATGAGAACAAAAGAAAGCTTACATTCACTTTGTTGAGTGCAGCCTATCTTATGCAAAGATAGTGCAAATGAAAACAAAAGA

>NC_014370|3|3|1464193-1464289|CRISPRCasFinder
TGCAAAGATAGTGCAAATGAGAACAAAAGA	AAGCTTACATTCACTTTGTTGAGTGCAGCCTATCTTA
TGCAAAGATAGTGCAAATGAAAACAAAAGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_014370.1\|WP_044045909.1\|1476719_1477010_-\|hypothetical-protein	unknown	unknown	unknown
NC_014370.1\|WP_146160285.1\|1459531_1459945_+\|hypothetical-protein	unknown	unknown	unknown
NC_014370.1\|WP_013264162.1\|1461178_1462207_-\|nitroreductase	unknown	unknown	gnl\|CDD\|184853
NC_014370.1\|WP_013264265.1\|1470499_1470907_-\|FMN-binding-protein	unknown	unknown	gnl\|CDD\|377242
NC_014370.1\|WP_013264071.1\|1470186_1470471_-\|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl\|CDD\|224278
NC_014370.1\|WP_013264788.1\|1460217_1460643_+\|hypothetical-protein	unknown	unknown	unknown
NC_014370.1\|WP_013264650.1\|1452570_1453917_+\|adenylosuccinate-lyase	unknown	unknown	gnl\|CDD\|236452
NC_014370.1\|WP_013263964.1\|1465321_1466029_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NC_014370.1\|WP_013264210.1\|1463280_1464165_-\|tRNA-threonylcarbamoyladenosine-dehydratase	unknown	unknown	gnl\|CDD\|224100
NC_014370.1\|WP_013264918.1\|1457244_1457904_+\|membrane-protein	unknown	unknown	gnl\|CDD\|368573
NC_014370.1\|WP_013264422.1\|1464364_1465225_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225543
NC_014370.1\|WP_013264977.1\|1454056_1455601_+\|pseudouridine-synthase	unknown	unknown	gnl\|CDD\|224108
NC_014370.1\|WP_013264068.1\|1468969_1469983_+\|aspartate-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|237845
NC_014370.1\|WP_044045908.1\|1466113_1468231_-\|cation:proton-antiporter	unknown	unknown	gnl\|CDD\|223551
NC_014370.1\|WP_013264810.1\|1471128_1472952_+\|lipoyl-synthase	unknown	unknown	gnl\|CDD\|235493
NC_014370.1\|WP_013264359.1\|1455741_1457133_+\|asparagine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235176
NC_014370.1\|WP_013263947.1\|1474818_1476711_-\|DNA-mismatch-repair-endonuclease-MutL	unknown	unknown	gnl\|CDD\|234630
NC_014370.1\|WP_013264334.1\|1473126_1474290_-\|OmpA-family-protein	unknown	unknown	gnl\|CDD\|143586
NC_014370.1\|WP_013264870.1\|1462203_1462797_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_014370.1\|WP_044046000.1\|1458226_1459411_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_014370.1\|WP_013264359.1\|1455741_1457133_+\|asparagine--tRNA-ligase	gnl\|CDD\|235176	PRK03932, asnC, asparaginyl-tRNA synthetase; Validated.	0
NC_014370.1\|WP_013264162.1\|1461178_1462207_-\|nitroreductase	gnl\|CDD\|184853	PRK14851, PRK14851, hypothetical protein; Provisional.	6.09331e-16
NC_014370.1\|WP_013264810.1\|1471128_1472952_+\|lipoyl-synthase	gnl\|CDD\|235493	PRK05481, PRK05481, lipoyl synthase; Provisional.	7.33884e-165
NC_014370.1\|WP_013264265.1\|1470499_1470907_-\|FMN-binding-protein	gnl\|CDD\|377242	pfam04205, FMN_bind, FMN-binding domain. This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins.	1.54955e-09
NC_014370.1\|WP_013264918.1\|1457244_1457904_+\|membrane-protein	gnl\|CDD\|368573	pfam05708, Peptidase_C92, Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family. Amidase_YiiX is a family of permuted papain-like amidases. It has amidase specificity for the amide bond between a lipid and an amino acid (or peptide). From the structure, a tetramer, each monomer is made up of a layered alpha-beta fold with a central, 6-stranded, antiparallel beta-sheet that is protected by helices on either side. The catalytic Cys154 in UniProtKB:Q74NK7, Structure 3kw0, is located on the N-terminus of helix alphaF. The two additional helices located above Cys154 contribute to the formation of the active site, where the lysine ligand is bound.	2.2926e-13
NC_014370.1\|WP_013263964.1\|1465321_1466029_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	5.74643e-117
NC_014370.1\|WP_013264650.1\|1452570_1453917_+\|adenylosuccinate-lyase	gnl\|CDD\|236452	PRK09285, PRK09285, adenylosuccinate lyase; Provisional.	0
NC_014370.1\|WP_013264210.1\|1463280_1464165_-\|tRNA-threonylcarbamoyladenosine-dehydratase	gnl\|CDD\|224100	COG1179, COG1179, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism].	2.38552e-93
NC_014370.1\|WP_013264071.1\|1470186_1470471_-\|antibiotic-biosynthesis-monooxygenase	gnl\|CDD\|224278	COG1359, COG1359, Uncharacterized conserved protein [Function unknown].	1.01451e-19
NC_014370.1\|WP_013264422.1\|1464364_1465225_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|225543	COG2996, COG2996, Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only].	2.18112e-73
NC_014370.1\|WP_013264977.1\|1454056_1455601_+\|pseudouridine-synthase	gnl\|CDD\|224108	COG1187, RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis].	2.05711e-83
NC_014370.1\|WP_013264068.1\|1468969_1469983_+\|aspartate-semialdehyde-dehydrogenase	gnl\|CDD\|237845	PRK14874, PRK14874, aspartate-semialdehyde dehydrogenase; Provisional.	0
NC_014370.1\|WP_044045908.1\|1466113_1468231_-\|cation:proton-antiporter	gnl\|CDD\|223551	COG0475, KefB, Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism].	1.41468e-57
NC_014370.1\|WP_013263947.1\|1474818_1476711_-\|DNA-mismatch-repair-endonuclease-MutL	gnl\|CDD\|234630	PRK00095, mutL, DNA mismatch repair endonuclease MutL.	4.4944e-180
NC_014370.1\|WP_013264334.1\|1473126_1474290_-\|OmpA-family-protein	gnl\|CDD\|143586	cd07185, OmpA_C-like, Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA. OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.	7.84239e-20
NC_014370.1\|WP_013264870.1\|1462203_1462797_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	9.58224e-10

>NC_014370.1|WP_013264210.1|1463280_1464165_-|tRNA-threonylcarbamoyladenosine-dehydratase
MQNQFSRTQLLLGKPAIDTLNGSRVAVFGVGGVGGYAVEVLARSGVGAIDVIDDDRVCLTNVNRQLLATTRTVGKHKVDVAEERIHSINPRCIVRKYQTFYLPDNADQFDFSHYDYVIDCIDTVTAKLDLIYRCHEMNIPLLSCMGAAYKLDATQFRVTDIFKTINDPLAKVIRKKLRKTKIKHLKVVYSPEEPLESIEQPEISCRFHCICPDKDMRKCTDRHTIPSSNAWVPAAAGLIAGGEAVKDLVNLANTMRIRPEDEATSEPARIAHERAAKMLEEHKRLKAEKAAADK
>NC_014370.1|WP_013264870.1|1462203_1462797_-|TetR/AcrR-family-transcriptional-regulator
MKNREQTESRILEAVASIVESEGFEKLGINTIASKANVSKMLIYRYFGGLEELIAQFIMQKDYWANTGTVIINPQSVGDSIKNMFRKQIEQLRNDVTLRRLCRWELSCNNTSIEQLRDKREENGCSLIKLVSTLTGCSNTEVASLASILSAAISYLALIEDQCLSYNGISLQTDKGWNEIMKGVGMIVDLWIKSIQE
>NC_014370.1|WP_013264162.1|1461178_1462207_-|nitroreductase
MRKVIIVFVIFMGFMDNIMAQNPDYLFMIENACKAPSGHNTQPWLFKIRESEIDIYPDLSKELPVVDPSHRELFVSLGCATENLCIAAQEKEYQTEVKVIKDSFIRVLLTKDKKKQFESSLFSQIAVRQTNRSVYDGKEIPKDSINLLKATSNDPSISIYFYKRGTVDYEKVANMVYAGNSLQMNNEAFKSELTKWMRYNKKYQNNTRDGLSYATFGAPNVPLFLAKFIMSKAINAKTQNKGDRKKIASASHFVLFTTKDNTVEQWVALGRTLERILLRSTQMGIANAYLNQPNEENDITKEMVKQLQISNEYPTILIRLGYGKKMPYSLRRDYRSCILPAD
>NC_014370.1|WP_013264788.1|1460217_1460643_+|hypothetical-protein
MQIQGTGLSKEFKPYELCCDLGYNITDNLYADLRYENAIALFKENGVKDYAHSHIVGLNLGYIVYHTENCNIGAQIGYGSNMKRKNSDWKYDYYEAMAFTDLGTCKIKPRFGLGIRHYNSRTNLYKDRTVVFVSIGFGINW
>NC_014370.1|WP_146160285.1|1459531_1459945_+|hypothetical-protein
MIKKKKQQSKVDKFLITFAIFLTLWGVKACIDSQPRSSKNSVDNQYESSISIGDNVEVIKTTIGLIDEASVDEFGNAAVAGDATGVDQLIITGKGRQIPAGEQGKVIKRTVSADRIRLNDGTAWWIPISADLKKINE
>NC_014370.1|WP_044046000.1|1458226_1459411_+|hypothetical-protein
MIQNVFDELTKQLRKNIEAQDYYKSIVTEIRIGYNANANVIQLMHPSQVLDLRTEDLIFPDREWDIDKEFEEAIAIYFTFSMKADKKELQLFQELDIRKYFKEIKDFGIRAYAIDCGKDYNKAATYVNIILEKVYNVSEGSTITIETSDFNNIESAKICKESLTVPYKITGIATRVKEQKEDTLSNETPLPEISDKTYNRLLFGAISIIILILIVFIVNMTQKETPTTDDIRAATQDTTLYVDSASTAPFGVVSSNSETSISTQETASEPEQNQVIGKWIETSYGNNGATWLLEKEASTGRLLLTSRLGDIIQSYNCTKRRIKGNNSYIFHDPNVSGNNGLFSMRKGTTIYYISGFDNNSDAILVPTQDGSAKIYSNDIDNRYYELFSDLSSVN
>NC_014370.1|WP_013264918.1|1457244_1457904_+|membrane-protein
MKLNKILSNLILLLLILLVSCSTDSFQDEDISLRNLHEGDLMFVVKETSNPITDATQGINGLKIDHVAIFHHTDSADYALEAYGKAVSLTPLTNFLNRTKGKEGKPLIAVGRVIVDCDMNTSMKRALSYLGRPYDRFYMPDDKEIYCSELIQKSFVDHHGLPIFSTIPMSFHDNNGKILDAWTQFYAFYHHEVPEGEPGTNPGQLSRDKAVKVNYKLEK
>NC_014370.1|WP_013264359.1|1455741_1457133_+|asparagine--tRNA-ligase
MKRTKIVDALACTDFGKDINVKGWVRSHRSSKAVDFIALNDGSTIKNIQVVVDPSTIDEDKLKSITTGACISVIGTLVESQGAGQTSEIQCKEIEIYGLCPSDYPMQKKGQSFEYMRKYGHMRLRTNTFGAVFRIRHNMAIAIHQYFHEHGFYYFHTPLITGSDAEGAGNMFQVTTLDLDRVAKGGEVDYSADFFGKRTNLTVSGQLEGELGATALGAIYTFGPTFRAENSNTPRHLAEFWMVEPEVAFIDKDELMDLEEDFIKYCVRWALENCKDDLEFLNKMIDKELIARLEGVLKEDFARLTYTEGFEILQKAAADGVKFEFPITHWGMDLSSEHERYLVEEHFKRPVIMTDYPSEIKSFYMKKNEDGKTMQGTDVLFPRIGEIIGGSVREESYEKLVEEIESRGMKRDIYDWYLDTRKYGTCPHGGFGLGFERLILFVTGMQNIRDVIPFARTPKNAEF
>NC_014370.1|WP_013264977.1|1454056_1455601_+|pseudouridine-synthase
MAEEFENKEVQSEQNENSRDGYSAAEQGGYQREYRGTGRTQRPRIHSQRAYSSDKANSSNDEGGFRPEGFGSGLQSAGRPQQGGYRPRQNSYGGGYNNNRGGYQSRPQQGGYRPRYNSNGEEGGYQPRQQGGYNRGGYQSRPQQGGYRPRYNNDENGYQPQAYRPRYNANNGAEGEENNNYQANQGGYQPRQGGYQPRQQGGYQSRGGYNNNRGGYNNNRGGYQSRGGYNNNRGGYNNRGGYNQGGYRQHSTDYDPNAKYSLKKRIEYKEENYDPNEPIRLNKYLANAGVCSRREADEFILSGAVTVNGEVVKELGSKVMRTDEVYFQDKLVSLEKKVYVLLNKPKDYVTTSDDPQQRKTVMDLVKGACPERIYPVGRLDRNTTGVLLLTNDGDLASKLTHPKFLKKKVYHVFLDKAITANDLQKISDGIELEDGEIKADAIEYADPQDQTQVGIEIHSGKNRIVRRIFESLGYRVVKLDRVQFAGLTKKNVRRGDWRFLTEKEVDMLRMGAFE
>NC_014370.1|WP_013264650.1|1452570_1453917_+|adenylosuccinate-lyase
MTLDALTAVSPIDGRYRSKTESLADYFSEYALIRYRVRVEIEYFITLCELPLPQLESFNSALFEQLRDIYRNFDEASAARVKEIESITNHDVKAVEYFIKEEFDKIGGLDDYKEFIHFGLTSQDINNTSVPLSVKEALEEVFYPQVEELIAQLKEYAEAWEDVPMLAKTHGQPASPTRLGKEVEVYVYRLSEQLATLRNCKMTAKFGGATGNFNAHHVAYPQHDWRAFGNRFVSEKLGLEREQWTTQISNYDHLGSVFDAIRRINTIIIDLDRDFWMYISMEYFKQKIKAGEVGSSAMPHKVNPIDFENSEGNLGVANAILQFLAQKLPVSRLQRDLTDSTVLRNVGVPVGHSVIAIQSTLKGLRKLILNEEKLREDLENTWAVVAEAIQTILRREAYPHPYEALKALTRTNEKMTEETIHAFVQTLNVSDSVKAELMAITPYNYTGI
>NC_014370.1|WP_013264422.1|1464364_1465225_-|GntR-family-transcriptional-regulator
MSKIKLGAYNTLTVLKIALREGNGDPFGIYLDGGPAGEILMPQKYVPEGTEIGDELEVFVYLDQDERPIATTEEPLAQVGDFAYLECSWVNEYGAFLSWGVMKDLFCPFREQKKRMTIGNSYIVYIHLDEESYRLVASAKVEHYLDEQPRGYKHGQEVDLLIWQKTDLGFKVIVDNKYPGLIYEDQVFQYVHTGDRLKGYISTVRRDGKIDCTLQPTGQQHAEGFAEVLLQYLKDNDGVCDLGDKSEAEDIKRRFQVSKKVYKRAVGDLYKRHLITVDPLSIRLVK
>NC_014370.1|WP_013263964.1|1465321_1466029_-|ABC-transporter-ATP-binding-protein
MIDIKNITKSFGSLQVLKGIDLRIEKGEVVSIVGPSGAGKTTLLQILGTLDKPDSGSVVVDGIDVGSLSAGKLSDFRNQHLGFVFQFHQLLPEFTALENIMIPAYIAGKKNKDARQRAEELLEFMGLSDRANHKPNELSGGEKQRVAVARALVNNPAVILADEPSGSLDSKNKQELHQLFFDLRDKFGQTFVIVTHDEGLAQITDRTIHLKDGLIESLPQPLRKEGSATIKIENE
>NC_014370.1|WP_044045908.1|1466113_1468231_-|cation:proton-antiporter
MLNLSQYFPITDPTLIFFVVLLMILLSPIIMGRLRIPHIIGMVLAGVLVGKYGLNILGRDASFELFGRVGLYYIMFLAGLEMDMEGLKKNRNRVMIFGMLTFLIPFAMTYFMGVSLLGYIPLASLLLAAIMASNTLIAYPIVGRYGLTRHTSSTLSVGSSMMALFMALIVMASIVNSFHGNGGILFWLLFILKFVAYCVGLIMVIPRVTRWFLRRYSDAVMQFIFILAVVFLSAALSDAVGLEGIFGAFMSGLILNRFVPKVSPLMNRIEFTGNALFIPYFLIGVGMLINVRLLFAGSKILWVVFCIVFFGTLGKAVAAYVAARIFRMSWLAGHMMFGLTSAHAAGAIAMVMVGRRLEVAPGQYLFGDEVLNGIVIMILFTCVISTVITERAAQRLRLQEKEDQNMMKNLDDEKILIPVKYPEYSDNLITMATLMRNPRLKRELVALNVVYDDVNMRHNQAEGQRLLDHLCHLASASDVPMVTQVRVAANIANGIKHAFKEFQASEILMGLHFHKEINRSFWGEFTRSLYNGLSRQIIVTRILQPLNTIRRIQVAIPSRAEFEPGFYRWLERLARMAGNLECRIAFHGRNETLQLVNEFIRNRFPSVRAEYEEMAHWKELPTLGSQVREDHLFVIVTARKGTISYKTAMERLPEELNKFIKGKTIMIIFPDQYGSEMDDMTFAQPQHTEERSAYEAVREWIHNKV
>NC_014370.1|WP_013264068.1|1468969_1469983_+|aspartate-semialdehyde-dehydrogenase
MKVAIVGASGAVGQEFLRILAERNFPMDDLVLFGSERSAGKKYTFKGKEYEVKLLQHNDDFKDVDIAFTSAGGGTSAEFAETITKYGAVMIDNSSQFRQDNDVPLVVPEINAEDALNRPRGIIANPNCTTIMMVVVLNPIDKLSHIKKIHVSSYQSASGAGAAAMAELQQQYKELVETGEVKTIEKFPHQLAYNVIPQIDKMTENDYTKEEVKMFNETRKIMHSDVRTSATCVRVSSLRSHSEAVWFETERPLSVEEIREALKAAPGVTVVDDPQNYVYPMPLESAGHDDIYVGRIRKDLADDNGNTLWLTGDQIRKGAALNAVQIAEYLIKVGDVK
>NC_014370.1|WP_013264071.1|1470186_1470471_-|antibiotic-biosynthesis-monooxygenase
MIRLNAFFKVKAGVTTAQVKALTDELVELSRKDEGNKGYDLFESTTQPGVFLFCETWADKACLTRHARSEHFTRIVPELEKLTDGGLSIEQFER
>NC_014370.1|WP_013264265.1|1470499_1470907_-|FMN-binding-protein
MLKKQFVSVAAVAVLTTGVAFAAVQQDKVMYKQADGTYVVNTTSLCSNVKGFKGATPVEVYIKNNKVIKVEALPNREGPKFYDKVKQGLFPKFNGMKLSKAAKAESLDGVTGATYTSRAVKENIAAAVAYYKKNK
>NC_014370.1|WP_013264810.1|1471128_1472952_+|lipoyl-synthase
MKYILLPKPDTIHQLPFYFAVEEYVARHYTDDDYFMGWRVNPTVMLGRNQLIDNEVNTDYCKEHKIDIFRRKSGGGCIYADKGCIQFSYISCAVNANEAFADYMQRMADLLKGLKIDAQLSGRNDILINGTKVSGCAFYQLSNRSVLHNSLLFDTQLDHLSNALTPAKEKLQSKGVASVRQRVTNVATYIQLDILAFMDYVRQEMCGTEVLELTEEDMKGVAEIEKELSSDDFVYGKNPKYSLVRKHRFEGVGTLEAHIELKNNIIGSINMVGDYFLLGDIDHDFLSLLKGCEFTREAVEERLENIDLSTIIRGLKLRQFLRLLFGREPHVMKPKWLKIDLTSKKSTGETAGILAKHHMNTICTSGLCPNRSECWMARTATLMIGGDICTRKCRFCNTLSGRPRLLNPDEPRRVAESVKALKLRYAVITSVDRDDLPDYGAAHWIKTIEEIRRLNPDTKIELLIPDFMGKADLIRQVMATHPHVAGHNMETVRRLTPSVRSVARYERSLEVLREIANCGITAKTGFMLGLGETHDEILETMDDILSTGCQRLTLGQYLQPTAEHLPVKAYITPEMFAEYKRIALEKGFKHVVSGPLVRSSYHAAEGV
>NC_014370.1|WP_013264334.1|1473126_1474290_-|OmpA-family-protein
MKKLLIVLALAGVSMTGFAQDEVLTEKYSVATNSFWSNWFVQLGADWNAWYSNQEHGRDAAISPLKDFRSKPGAAFAIGKWFTPGIGLRTKIQGIWGKRVGADSNPASQLDNSNKYWIAQEQVMFNLSNLLCGYNENRVWNLIPFAGAGVGRSMSANRYAMGLSAGLQSSWRVSKGMRVYLEAGWNRYESDLDGAAYANNERRGWESHDNNLYAEIGLNFNIGKGTWKKSPDMEAINTQHQAALDALNARLQDAEEENTRLRNELANQKPVETVSESVKQLVTTPVSVFFEINQSTIASQKDLVNVQALAKYAKDNNNNLLVTGYADSATGSADYNQKLSERRATVVANELVKMGIENNKITTVGKGGVETLSPISFNRRATVQITE
>NC_014370.1|WP_013263947.1|1474818_1476711_-|DNA-mismatch-repair-endonuclease-MutL
MSDIIQLLPDSVANQIAAGEVIQRPASVIKELVENAIDAGATHIDVLVVDAGRTSIQVIDDGKGMSETDARLSFERHATSKIRKADDLFSLRTMGFRGEALASIAAVAQIELKTRMESEDLGTHLSIAGSRFTGQEPCSCPVGSNFLVENLFFNVPARRKFLKSNTTELNNIITAFERIVLVYPQISFTLHSNGTELFNLRACSYRQRIVEVFGKRLNQDLLPIDVDTSLCHIHGFVGKPESARKKAPHQYFFVNDRYMKHPYFHKAVITAFDRLIPQGEQVPYFLYFDVPAENIDVNIHPTKTEIKFENEQAIWQILLAAVKEAVGRFNDIPAIDFDTEGKPDIPVFNPNVGMSAPKVDFNPAYNPFKQTSQPAKSSVPDGWEELYADLGSGGEIRQSKLFKQREDEMISSSLGTVSDTVEEGTIIPSAATQSAAESLIEDKAPSHYQYKGCYIMTAVKSGLMIIDQHRAHIRILYEEYLHQLSEHKVHSQKVLFPEMVQFSVSDQVVLDQILPEMAEMGFQLDSLGGGSYAVNGVPAGIEGLNVVALINDMVASAMESGTSAKEEIDQALALSLARNAAIPQGQVLSSMEMDNIVNELFACSNVNYTPSGEPVIAIMKQQDIEHLFDS
>NC_014370.1|WP_044045909.1|1476719_1477010_-|hypothetical-protein
MLFFQSSRPRRFHHEYMYVDERKELLNDIEQRARRELNGEEVPEGKYREELQRKISGSLKPEVLRHRGNRFTAMWVSLILSAGVIALLTLFLFFAL

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Crispr_ID: NC_014370_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014370_4

1574324-1574456

Orphan

Consensus_repeat	Method
ATAAAGACACCCACAACGCATTTGTCTTAACTCCATTTCACTCCTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014370_4

>merge|NC_014370|4|1574324-1574456|CRISPRCasFinder
ATAAAGACACCCACAACGCATTTGTCTTAACTCCATTTCACTCCTTCAACTCCTTTAACTCCCAAATAGGAACAATGGAAAATCAACATAAAGACACCCACAACACATTTGTCTTAACTCCATTTCACTCCTT

>NC_014370|4|4|1574324-1574456|CRISPRCasFinder
ATAAAGACACCCACAACGCATTTGTCTTAACTCCATTTCACTCCTT	CAACTCCTTTAACTCCCAAATAGGAACAATGGAAAATCAAC
ATAAAGACACCCACAACACATTTGTCTTAACTCCATTTCACTCCTT

Protein	Signature genes	Signature genes Name	Protein_function
NC_014370.1\|WP_013263906.1\|1572827_1574165_+\|dNTP-triphosphohydrolase	unknown	unknown	gnl\|CDD\|234897
NC_014370.1\|WP_044045917.1\|1562403_1562796_+\|VanZ-family-protein	unknown	unknown	unknown
NC_014370.1\|WP_013263858.1\|1592518_1593172_+\|DUF4145-domain-containing-protein	unknown	unknown	gnl\|CDD\|372658
NC_014370.1\|WP_013264389.1\|1589218_1592503_+\|Eco57I-restriction-modification-methylase-domain-containing-protein	unknown	unknown	gnl\|CDD\|380297
NC_014370.1\|WP_013264538.1\|1562755_1563253_-\|CYTH-domain-containing-protein	unknown	unknown	gnl\|CDD\|143629
NC_014370.1\|WP_013264023.1\|1584716_1585337_-\|DUF2238-domain-containing-protein	unknown	unknown	gnl\|CDD\|378345
NC_014370.1\|WP_013264315.1\|1582594_1583062_+\|ribonuclease-H	unknown	unknown	gnl\|CDD\|260015
NC_014370.1\|WP_013264606.1\|1579422_1579911_-\|hypothetical-protein	unknown	unknown	unknown
NC_014370.1\|WP_036863029.1\|1572164_1572602_-\|dUTP-diphosphatase	unknown	unknown	gnl\|CDD\|234802
NC_014370.1\|WP_013264368.1\|1564944_1566753_-\|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl\|CDD\|223953
NC_014370.1\|WP_013264921.1\|1580543_1582364_+\|arginine--tRNA-ligase	unknown	unknown	gnl\|CDD\|223097
NC_014370.1\|WP_013264269.1\|1570406_1572143_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|274350
NC_014370.1\|WP_013263864.1\|1575791_1579238_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|273041
NC_014370.1\|WP_013264029.1\|1569498_1570410_-\|DUF4292-domain-containing-protein	unknown	unknown	gnl\|CDD\|372917
NC_014370.1\|WP_167310034.1\|1563334_1563472_-\|hypothetical-protein	unknown	unknown	unknown
NC_014370.1\|WP_004361424.1\|1563657_1564773_-\|peptide-chain-release-factor-2	unknown	unknown	gnl\|CDD\|234799
NC_014370.1\|WP_013264323.1\|1574528_1575524_+\|esterase	unknown	unknown	gnl\|CDD\|283403
NC_014370.1\|WP_044046006.1\|1585837_1589215_+\|helicase	unknown	unknown	gnl\|CDD\|197275
NC_014370.1\|WP_013264050.1\|1583397_1584255_-\|enoyl-ACP-reductase	unknown	unknown	gnl\|CDD\|187630
NC_014370.1\|WP_044045918.1\|1567473_1569498_-\|M23-family-metallopeptidase	unknown	unknown	gnl\|CDD\|227278

Protein	Function_ID	Function_description	E-value
NC_014370.1\|WP_013263906.1\|1572827_1574165_+\|dNTP-triphosphohydrolase	gnl\|CDD\|234897	PRK01096, PRK01096, deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional.	2.9875e-137
NC_014370.1\|WP_013263858.1\|1592518_1593172_+\|DUF4145-domain-containing-protein	gnl\|CDD\|372658	pfam13643, DUF4145, Domain of unknown function (DUF4145). This domain is found in a variety of restriction endonuclease enzymes. The exact function of this domain is uncertain.	2.114e-13
NC_014370.1\|WP_013264389.1\|1589218_1592503_+\|Eco57I-restriction-modification-methylase-domain-containing-protein	gnl\|CDD\|380297	NF033455, BREX_6_MTaseX, BREX-6 system adenine-specific DNA-methyltransferase PglX.	1.7674e-10
NC_014370.1\|WP_013264538.1\|1562755_1563253_-\|CYTH-domain-containing-protein	gnl\|CDD\|143629	cd07891, CYTH-like_CthTTM-like_1, CYTH-like Clostridium thermocellum TTM-like subgroup 1. This subgroup contains the triphosphate tunnel metalloenzyme (TTM) from Clostridium thermocellum (CthTTM) and similar proteins. These are found primarily in bacteria. CthTTM is a metal dependent tripolyphosphatase, nucleoside triphosphatase, and nucleoside tetraphosphatase. It hydrolyzes the beta-gamma phosphoanhydride linkage of triphosphate-containing substrates including tripolyphosphate, nucleoside triphosphates and nucleoside tetraphosphates. These substrates are hydrolyzed, releasing Pi. Mg++ or Mn++ are required for the enzyme's activity. CthTTM appears to have no adenylate cyclase activity. This subgroup consists chiefly of bacterial sequences. These enzymes are members of the CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) superfamily, which have a unique active site located within an eight-stranded beta barrel.	3.09628e-79
NC_014370.1\|WP_013264023.1\|1584716_1585337_-\|DUF2238-domain-containing-protein	gnl\|CDD\|378345	pfam09997, DUF2238, Predicted membrane protein (DUF2238). This domain, found in various hypothetical bacterial proteins, has no known function.	3.91098e-38
NC_014370.1\|WP_013264315.1\|1582594_1583062_+\|ribonuclease-H	gnl\|CDD\|260015	cd13935, RNase_H_bacteria_like, RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner. This family includes bacterial ribonuclease H (RNase H) enzymes. RNases are divided into two major families, Type 1 and Type 2, based on amino acid sequence similarities and biochemical properties. RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner in the presence of divalent cations. RNase H is widely present in various organisms, including bacteria, archaea and eukaryotes. Most prokaryotic and eukaryotic genomes contain multiple RNase H genes. Despite the lack of amino acid sequence homology, type 1 and type 2 RNase H share a main-chain fold and steric configurations of the four acidic active-site residues and have the same catalytic mechanism and functions in cells. RNase H is involved in DNA replication, repair and transcription. One of the important functions of RNase H is to remove Okazaki fragments during DNA replication. RNase H inhibitors have been explored as an anti-HIV drug target because RNase H inactivation inhibits reverse transcription.	3.07378e-65
NC_014370.1\|WP_036863029.1\|1572164_1572602_-\|dUTP-diphosphatase	gnl\|CDD\|234802	PRK00601, dut, dUTP diphosphatase.	7.67455e-93
NC_014370.1\|WP_013264368.1\|1564944_1566753_-\|long-chain-fatty-acid--CoA-ligase	gnl\|CDD\|223953	COG1022, FAA1, Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism].	5.72556e-172
NC_014370.1\|WP_013264921.1\|1580543_1582364_+\|arginine--tRNA-ligase	gnl\|CDD\|223097	COG0018, ArgS, Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis].	1.08343e-141
NC_014370.1\|WP_013264269.1\|1570406_1572143_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	4.82063e-26
NC_014370.1\|WP_013263864.1\|1575791_1579238_+\|AAA-family-ATPase	gnl\|CDD\|273041	TIGR00376, DNA-binding_protein_SMUBP-2, DNA helicase, putative. The gene product may represent a DNA helicase. Eukaryotic members of this family have been characterized as binding certain single-stranded G-rich DNA sequences (GGGGT and GGGCT). A number of related proteins are characterized as helicases. [DNA metabolism, DNA replication, recombination, and repair].	8.26776e-39
NC_014370.1\|WP_013264029.1\|1569498_1570410_-\|DUF4292-domain-containing-protein	gnl\|CDD\|372917	pfam14125, DUF4292, Domain of unknown function (DUF4292). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 243 and 287 amino acids in length.	2.93386e-32
NC_014370.1\|WP_004361424.1\|1563657_1564773_-\|peptide-chain-release-factor-2	gnl\|CDD\|234799	PRK00578, prfB, peptide chain release factor 2; Validated.	3.30728e-151
NC_014370.1\|WP_013264323.1\|1574528_1575524_+\|esterase	gnl\|CDD\|283403	pfam05728, UPF0227, Uncharacterized protein family (UPF0227). Despite being classed as uncharacterized proteins, the members of this family are almost certainly enzymes that are distantly related to the pfam00561.	2.53385e-12
NC_014370.1\|WP_044046006.1\|1585837_1589215_+\|helicase	gnl\|CDD\|197275	cd09178, PLDc_N_Snf2_like, N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family. N-terminal putative catalytic domain of uncharacterized archaeal and prokaryotic HKD family nucleases fused to putative helicases from the Snf2-like family, which belong to the DNA/RNA helicase superfamily II (SF2). Although Snf2-like family enzymes do not possess helicase activity, they contain a helicase-like region, where seven helicase-related sequence motifs are found, similar to those in DEAD/DEAH box helicases, which represent the biggest family within the SF2 superfamily. In addition to the helicase-like region, members of this family also contain an N-terminal putative catalytic domain with one copy of the conserved HKD motif (H-x-K-x(4)-D, where x represents any amino acid residue), and have been classified as members of the phospholipase D (PLD, EC 3.1.4.4) superfamily.	1.14749e-31
NC_014370.1\|WP_013264050.1\|1583397_1584255_-\|enoyl-ACP-reductase	gnl\|CDD\|187630	cd05372, ENR_SDR, Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR. This bacterial subgroup of ENRs includes Escherichia coli ENR. ENR catalyzes the NAD(P)H-dependent reduction of enoyl-ACP in the last step of fatty acid biosynthesis. De novo fatty acid biosynthesis is catalyzed by the fatty acid synthetase complex, through the serial addition of 2-carbon subunits. In bacteria and plants,ENR catalyzes one of six synthetic steps in this process. Oilseed rape ENR, and also apparently the NADH-specific form of Escherichia coli ENR, is tetrameric. Although similar to the classical SDRs, this group does not have the canonical catalytic tetrad, nor does it have the typical Gly-rich NAD-binding pattern. Such so-called divergent SDRs have a GXXXXXSXA NAD-binding motif and a YXXMXXXK (or YXXXMXXXK) active site motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	2.75466e-99
NC_014370.1\|WP_044045918.1\|1567473_1569498_-\|M23-family-metallopeptidase	gnl\|CDD\|227278	COG4942, COG4942, Membrane-bound metallopeptidase [Cell division and chromosome partitioning].	1.05911e-20

>NC_014370.1|WP_013263906.1|1572827_1574165_+|dNTP-triphosphohydrolase
MNWQQLISNKRLGQEERHALRHDDRSEFKRDSDRLIYSAPFRRLQNKTQVFPLPGSVFVHNRLTHSLEVASLGKSLGDDVARRLIEIHPELRGTLFEEIGTIVQTACYAHDMGNPPFGHSGEKAMQAFFTEGPGISLKEKVSPHFWEDITHFEGNANAFRLLTHRFLGRREGGFVMTYSTLASIVKYPFSSTYASKHGKFGFFATEEETYKKIADELGIIQKDSSEAGICYVRHPLTYLMEAADDICYEIMDIEDSHKLKLLSFEETADLLLGFFDEETRKSIRKRIEEEGVTDQNEQVVYFRACAVGLLEAECVNVFVEHEEEILNGTFEGSLIKHISELPRQAYKHCTEVSVDRIYRSKAVLDVELSGYKIMETLMKALIGAAVEPEHFHSQQLIRSFSSQYDIQSPCLETRIMAVLDFISGMTDIYALDIYQKINGISLPLI
>NC_014370.1|WP_036863029.1|1572164_1572602_-|dUTP-diphosphatase
MIQIKVINKGHQQLPAYATSQSAGMDLRANIDAPIVLQPMERRLIPTGLHIALPVGFEAQVRPRSGLALKHGLTVLNSPGTIDADYRGEIMVLLINFSDEPFTINDGERIAQMVIARHEQAEFVEVEELDETERGEGGYGHTGVK
>NC_014370.1|WP_013264269.1|1570406_1572143_-|tetratricopeptide-repeat-protein
MFNNVILKVTKMRRTLLALALLGGSLAMHADREDSLQSYNYFFLEAIRQQEMGNLTAAFDLLCHARDLNPQAPEVYYQLAAFYVDMKKDAVAREYFEKAASLDPENSAYQEKLGKLYVSQKDYPNAIKAFERLYESNKTRSDVLQILYQLYGSQNDYKMMIKCLERLETLEGTNEQISLSKMQLYEQMGEKRKEYDELKALVDSHPLDLNYRVMFGNWLLQNGKKKEALQKYRDVLKEDPDNSLAKLSMMDYYNNIGDKATVKTILQELLQSPKTEKEAKLELLRQVITSSQKDNTPDSTEVMRLFSVALAVPQEDADIYMLKAAYMTLRKQPKAAVNRVYEQALEVEPDNSRARIALIQNIWDTQDYDKVIAICRPAIEYNPDEMAFYYFQGMAQFQKHDGDAALETFRKGVGQIKPDSDPSIVSDFYAIMGDILHEKGRNKEAFQAYDSCLQWKADNVAALNNYAYYLSEANENLTKAEQMSYKTIKAEPNNSTYLDTYAWILFQQKRYEEAKIYIEQAIRNDSTLSNVVKEHAGDIYAQTGDIEKALEFWRKALEGNKENATLRKKIELKKYIAE
>NC_014370.1|WP_013264029.1|1569498_1570410_-|DUF4292-domain-containing-protein
MKKTKILLVSMTALLLASCGTKKAVIQQKPVQDNKAAQQTAPATKDSKMQSVVVMQRVADNALYQKNLVSNLTFTLNDGHKDITVPGILRMRKDEVIRLQLLIPILRSEVGRIEFAKDYVLFIDRIHKQYVKASYDEVGFLRDNGINFYSLQSLFWNQVFIPRQQKVSEADLSQFAVDESKAQTEGSTLISLKDGKMDYKWSVNPKSNQIVLTTVTYNSNTHGASKLSWSYDDFKAFGSKLFPASQMLTINTPKFGQKPAKTLKASFDLESFSDISDWEVFTTPSDKYTKVSVEDILGKLMNF
>NC_014370.1|WP_044045918.1|1567473_1569498_-|M23-family-metallopeptidase
MKRLSLLFILSIMCMLSVSAQHSRKHRKQQKTAVAQSVEPQTTVKGKGKKAVNAINNNHAVAPATPVKGQKPIVEKLQTQPQPKGKQQQGKLQHQQQLKGQQPQLKGQPAQVKGQQVVRGKGAVRNAHVGKKGAKGPAYVTTEEIKGLQQQNLKLQKEISEHEEEMKVKQKDVDDRLQKIVRLDTEIGQHQRTIDTIATDIKGLDSNIGILKGQLASLEAQLGERRARFIRSMRYMARHRSIQDKLMFVFSAKNLTQMYRRLRFVREYAAYQRAQGEQLKAKQMQVDEKHTQLKQVRVNKSNLLYKDRQVHAQMERKRVEQQTVVSSLQNDQKVLQGVIAQRRQQQQALNAQIDRLIQIEIQKARERAIAEAKAQAAARAAAAKKRAEELARKKAAAEAAARENARRIAEAKEREAKAKAAARAAAEAAEKARQEAAARAAAARAAAEKARQEALQKERAAARERAIRKVEEQEAAAKAAQEKAEARAAAEKARADQMAREAEANRVAAERKADADRERAAREAEAARASAAENNDMLSSADRAITGNFANNRGRLPMPLSGQIVSHFGQYNVAGMSNIRLNNDGINIKGAPGSAVRSVFMGEVSGVFMAGGMSVVMIRHGIYISVYANLGSVGVSKGQKVGTGQTIGTVGKTGILQFQLRKETAKLNPEQWLR
>NC_014370.1|WP_013264368.1|1564944_1566753_-|long-chain-fatty-acid--CoA-ligase
MQTIGHLSVLIHEQAKKYGAKPAITFRNFGSLDWKTVSWNQFSMRVKEVSNALLNLGMKPQETIAVFSQNCIHHLYTDYGAYGVRVISIPFYATSSEQQIQYMIQDANVKFLFVGEQEQYDKARRIQSLCPTLERIIVFDSSVRLSQHDPNSIYFADFLKLGEGFPREAEVEERLAQANYDDICNILYTSGTTGESKGVILTYKMYQAAMDANRKSVPVNEKDRVINFLPFSHVFERGWACLSLAAGAELIVNTYPKEIQQSMRETHPTSMASVPRFWEKVYVAVKERMDKSSIVQRKLFYHALNVGRKRNIQYLARGKRVPLTLEMEYKFVNKTVLSLVRKQLGLENPHLFPTAGAYVSPEVEEFVHSIGINMIVGYGLTESLATVTCDHVGQPYTVGSVGRPLEGIDIKISDEGEVMLKGPTIMPGYFRRDTTNAEAFDKDGYFHTGDAGYMKDGELFLKERIKDLFKTSNGKYIAPQMVEAMLLVDKFIEQVSVIADQRKFVSALIVPEYSVLEEWARENHIEFKDREELCQDKRVNEMMRERIETLQQRLASYEKIKRFTLLAHHFSMENGELTNTLKLKRSVVNRRYHDVIEKMYEE
>NC_014370.1|WP_004361424.1|1563657_1564773_-|peptide-chain-release-factor-2
MITADQLKDIQERTEALHRYLDIDKKRIEFEEEQLRTQAPDFWDDPARAQEQMKKVKDIEKWVKDYDKARALADEVQLAFDFYKDELVTEEEVDTAYAKVLKVIEGLELKNMLRQEEDPMECVMKINSGAGGTESQDWASMLMRMYMRWGEAQGYRVTISDIQEGDEAGIKSVTMKFEGGEYAYGYLKSENGVHRLVRVSPFNAQGKRMTSFASVFVTPLVDDTIEVYVDPARVSWDTFRSSGAGGQNVNKVESGVRLRYQYEDPDTGEQEEILIENTETRDQPKNRAKAMQLLKSQLYDRAMKKRMEEQAKIEAGKKKIEWGSQIRSYVFDDRRVKDHRTNYQTSDVDGVMDGKIDDFIKAYLMEFPTEE
>NC_014370.1|WP_167310034.1|1563334_1563472_-|hypothetical-protein
MSERSKINRKERELKQEKQANRVVAWLAVILVALGVLTIIIASNS
>NC_014370.1|WP_013264538.1|1562755_1563253_-|CYTH-domain-containing-protein
MSGLEIERKFLVHKNMDWKKHASSCSHMQQGYFAAVNTVRVRIRDDKGYLTIKGPSRTGGLSRYEFEKEITLEEAQQLMLLCEPGVIDKHRYLVPFEGHTFEIDEFHGDNDGLVLAEVELGSEDESFDKPDFIGLEVTGNRHFYNSQMRRNPFKLWRDIVPEEYR
>NC_014370.1|WP_044045917.1|1562403_1562796_+|VanZ-family-protein
MSITKHILTKYPFSCIIVIGTWILCFMTIPETPLSSVRFIDKWTHSLIYLVLGLSISLEYLRNTKQPSPKFIIVWVWFLPIIMGGLIEVLQSYCTNGNRSGEWLDFFADAIGSTIAVLIGILLVRYRAKA
>NC_014370.1|WP_013264323.1|1574528_1575524_+|esterase
MENQYKKTFPDLMVGKKIIYVHGFMSAGSSHTVQILRDYMPEATVIAPDLPIHPEEAMELLRNLVNTEKPDLIIGTSMGGMYTEMLYGVDRICVNPAFQMGTTISETNMMGKQVFQNPRQDGVQEVIVTKALVKEYKEITEKCFSQVTEEEQQHVFGLFGDADPVVHTFDLFNEHYPQAIRFHGEHRLIEKAVFHYLMPVIRWIDDRQEGRERRTVLIDQNTLTDGYGKPKSSLNKAYEFLLDNYNVFFVCPAPTNNPSTITEQQAWIEDAFSAPAWNHTIFTNQPQLLYGDYFISSTEHDDFLGTSLLFGSEEFKTWEEIITFFERLGGQ
>NC_014370.1|WP_013263864.1|1575791_1579238_+|AAA-family-ATPase
MAHELFSRIADILSAPSEAQALIMHETLVIACHEGLKNTRHGFGNLSSQVESLCRQHNIAPQDIVAIQKMRRHSNSNAPILPEDVAYDCRALAIFVSAVVQEAIPSFLVGKIPARGRTTENIQITNYRYIRCIVREWDDSTIQVAVTNQDSSEELLTVDYMNTPDYIDFSYLRPMLRERMQLNLLDCTVTRKKVVPRLIVVEPDYLIDISTIANCFETYGHHPLLFTVNRLTPRLSNKHIVLGNFAGSALDDIINHPAGYDIKETFRSNFKEKALDYATCPDFDAASFKQDAERQVENIKGIVDEIFQTFDREKAILEPSFVCERLGIQGRVDLMTTDLKLLVEQKSGKNTFIERKYKNPHGSLHVEKHYVQVLLYYGILQYNFQLSPKNAHIQLLYSKYPLPDGLLEVEPLQKLIREAIRFRNQAVATEFWMADNGFDRMLPLLTPQTLNVEKQNDNFYNRYLLPQLTETLAPLHQLNDLERAYFTRMMTFVIKEQLVSKVGVQEGVGNSNADLWNMPLAEKKETGNIYTELTIIEKGRSSSFNGYDTITLAVPQQGEDFLPNFRRGDMIYLYSYKKNEAPDVRQSILFKGSLQEIHGDSITVHLNDGQQNPDLISGDYFAIEHAGSDIGGTSAIRSLYTFITSNEERRQLLLGQRVPCVDKSLTLSHSYHPDYDEIILKAKQAQDYFLLIGPPGTGKTSQALQFLVREQLAGNIYSQPSSAYSAEDSKHNKPSETINTQHSTPNTQTAILLLAYTNRAVDEICNMLTENDIDYIRIGNEFSCDPKYSDHLLKEVLDDNATLNSIKSTLADAQIVVATTSTMNSNAALFNIKHFDLAIIDEASQILEPNIIGLLTSQHRGGRAIRKFILIGDHKQLPAVVQQSDTEVLIEDETLKAIHLNSCTNSLFERLILTERAAGRTEFVGTLHKQGRMHPDIADFANRKFYAREQLECVPLAHQLEQTLAYNETSEDETDDVLKAHRMIFIPSKPCRQLNISEKVNTEEARIITDLLRRLYRQLGKNFDPQKSVGVIVPYRNQIAMIRKEIEKLGIPELEEISIDTVERYQGSQRDIILYSFTIQSRYQLDFLTANTFYEDGQPIDRKLNVAITRARKQLILTGNEQTLRHNQLFAELIDYIKEKGGYYAEKA
>NC_014370.1|WP_013264606.1|1579422_1579911_-|hypothetical-protein
MRKSIQKWTYALVASVFALVMCLSLSACGSDDDNDVNNGISPVLYSDFGGEIGVNYPLGISGKFVGFSIPKSQAGKIVDLTKDGDWVAGGSVVGGLYRYDDHFFQKGSYVYLLRTGANEIELRYKYIWKEGTATRTIEGNYKNVKMTTHQDAIDWAHRQGLH
>NC_014370.1|WP_013264921.1|1580543_1582364_+|arginine--tRNA-ligase
MKIEEQITVAALAAVKELYGTEVPEKMIQLQKTRSDFEGNLTLVTFPLLKTSRKKPEDTAQDLGEYLKKNCKAVADFNVVKGFLNLVIAQAAWTELLNDINADEKFGEKRVTDESPLVMIEYSSPNTNKPLHLGHVRNNLLGWSLAQIMEANGNKVVKTNIVNDRGIHICKSMLAWQKWGNGITPEQAGKKGDHLIGDFYVLFDKHYKEECKQLQEQYEKEGLTAEEAKEKAEHEAPLIKEAHDMLVKWEANDPEIRALWEKMNNWVYAGFDETYKALGVGFDKIYYESNTYLVGKKKVEEGLAKGLFIRKEDNSVWADLTNEGLDQKLLLRKDGTSVYMTQDIGTAEMRFNDYPIDKMIYVVGNEQNYHFQVLSILLDRLGFKWGKDLVHFSYGMVELPNGKMKSREGTVVDADDLVASMIENAKSLSEDKVNKLEGITEEEKNEIARIVGMGALKYFILKVDARKNMLFNPEESIDFNGNTGPFIQYTYARIRSILRKAEAQNITLPASLNDDAPLNEKEIALIQKLNDFGAAVAQAGIDYSPSGIANYCYELTKEFNQFYHDYSILNADTEAEKITRLMIAKNVAKVIKNGMALLGIEVPERM
>NC_014370.1|WP_013264315.1|1582594_1583062_+|ribonuclease-H
MKELVNPPTNRNDTVLPLPLEVRCPSWAVDAACSGNPGPMEYQCVDLQTGARVFHFGPVMGTNNIGEFLAIVHALALMEKQGIKDKVIYSDSYNAILWVNKKRCKTTFVRNAETEELHQIIARAEHWLQTHKVTTPIIKWETKQWGEIPADFGRK
>NC_014370.1|WP_013264050.1|1583397_1584255_-|enoyl-ACP-reductase
MSYNLLKGKRGVIFGALNEMSIAWKVAERAVEEGATITLSNTPIAVRMGTVNALSEKLNCEVIPADATNVEDLENVFKRSMEVLGGKIDFVLHSIGMSPNVRKHRTYDDLDYKMLDTTLDISAVSFHKMIQSAKKLDAINDYGSILALSYVAAQRTFYGYNDMADAKALLESIGRSFGYIYGREKHVRINTISQSPTMTTAGSGVKGMDKLFDFADRMSPLGNASADECADYCIVMFSDLTRKVTMQNLYHDGGFSNVGMSLRAMATYEKGLDEYKDENGNIIYG
>NC_014370.1|WP_013264023.1|1584716_1585337_-|DUF2238-domain-containing-protein
MIDKTKLMLVLLVMIVTVITCIHPIYPNEQTLQHIGTVLLLIPLTMDVFRKQLPMSAFIGIVGFTLLHVIGARYIYSYVPYKEWAVSLGLVEKGFFHDPRNHYDRLVHFSFGALMFPYFVYLCRKWVKQQSFVAVVMAWMMIQTGSLIYELFEWLLTIVMTAEEADYYNGQQGDMWDAQKDMALALVGSTGMFLVYAVRSLIRRGK
>NC_014370.1|WP_044046006.1|1585837_1589215_+|helicase
MARIYDNIKTKFTEGLQGIITNVGVKRVDFCVGYFNLRGWNLVVDQMDTLTGNYVYENDKHTFRKCRLLIGMHRPTEELIRQLYTDQPLPDANYVSQCKLEIARDFRRQLQLGFPTKQDEFTLRRLSAQMKEEKVCVKLYLREPLHAKLYLAYRPDDNFNKIQAIMGSSNLTYSGLTKQGELNAEFGDSDSAEKLAYWFDERWEDKFCLDITKELIEIIDNSWAGDKDIPPYYIYLKTAYHLSEEARSGIKEFTIPAEFKNCLFDFQQTAVKIAARHLNNEKRGGAMIGDVVGLGKTITACAIAKMYENTFGSNTLIICPANLQDMWEKYRKQYDMKADIMSMAKPIDVDNARYYKLIIVDESHNLRNSQGVRYRNIKDLIQKQDCKVLLLTATPYNKQYKDLSSQLRLFIDDDTDLGIRPEAYIRSIGGERKFAEKHEDFIRSIKAFERSEFQEDWQELMKLFLIRRTRTFIKENYAKTDSKNGRKYLEFKDGHKSYFPDRIPKAIKFQTTEGDQYSRLYSEEMVSLMESLKLPRYGLIHYLDEKKAETASKYEGNLIDNLSRAGERMMGFCKSTFFKRVDSSGYAFLLTLYRHILRNAVYLYAIDNKLKLPVSDENTFPEDFIEDADINKITADSDDNKEFLSNKSLLTIPKKMKDYMERAETYYNSLIGKNNVQWIDSKYFKRTLKQGLKKDCDQLIAMINLCDDWNPQTDQKLNELEKLLSNTHKDDKIIIFTQYSDTAAYVYKQLQKRGIKNIEKVTGDTKNPTAIVERFSPISNRADITKENELRILIATDVLSEGQNLQDAHIIINYDLPWAIIRLIQRAGRVDRIDQSSEQIYCYSFFPADKVEEIIRLRTRLNERINENAGIVGSDEVFFEGNEQNLRDMYNENSSSLDEDEDDIEVDLGSQAYQIWKNATDANPDLKRIIPAIPNIAYSTKAANNINEDGVITYARTYNDFDVLTWYNSKGDIVSQSQKRILQTMACTIKEPCLPAQDVHLSLVEKAVKSIKNENTNVGGILGSRFSTKRKIYELLNHYYEQPLNLFNTQEKKDILKFAIDQVYNYPLLENSKFILGRMMRTGNTHDDIVDTVIEMYENANLCRVDEDKIKHKDPVIICSMGLKA
>NC_014370.1|WP_013264389.1|1589218_1592503_+|Eco57I-restriction-modification-methylase-domain-containing-protein
MKRNIFNQYITASDFKGLFVSEMLWNNPTGATQLPEINIDNTTFHIEQIAERKGFQILHCQVEQIPSSAICKKIDHKIRKNAENYICIFILPETLHHLWIAPVKKVEKRDVVLIEYDSLDKAAFLFEKMESLSFSLDDNLTILDIIEKVQSAFLINSEKITKDFYAGFKKEHSNFAKFITGIDDHIDEKENKNKQWYASVMLNRLMFCYFIQKKEFLDGDVDYLRHKLEWTRNQEGEDRFFNKFYKGFLVNLFHDGLNTPKHNHEFEKIYGRIPYLNGGMFDVHQIEREYANLDIADEAFISLFDFFDKWHWHLDDRMTASGRDINPDVLGYIFEQYINDRAQMGAYYTKEDITEYIGRNTIVPYLMDAVKRKNEKHFRANSELWLYLKESGDKYIFDAMKKGVDQTIPEEIATGLDTTKPNLLERRCHWNERTSEAFALPTEIWRETIERLQRYNNIKEKITKGEITNINDFITYNLNIRQFVTDYLANTQDHLFVKHFYHALQHVTILDPTCGSGAFLFAALNILEPLYEVCINRMQEFNAKNPLLFKQELQEIEHKYRSNIQYFIYKSIILRNLYGVDIMVEATEIAKLRLFLKMVAVVEVDKRNPNLGLDPLPDIDFNIRCGNTLVGYATQEELERDLIEGDMYAREEFKEKVNDEMDKVSRTYEIFKNVQLHQAEDMAAFKKAKGELYQRLNTLNDLLNHKMYGAVESTKGYNAWYQSHQPFHWLAEFYEIINEHGGFDVIIGNPPYVEYNKKVKGVAVSDLYKLVGYKTLSCGNLYAYVLERSKNIMRQEGYISMIVPLSGHSTERMAPLVTNFYEKFGLHLHLNLSADANPQKLFEGVKFRLVIFTATNNGVGKYSTKYTRWLADERKNLFNALVRYNSIEDYTYQNIIPKIASPLFISIARKIKEEKVQYFVGIGNEQCLYHNAPVNWIRSHTFVPYFCSDRDGEGITTQLKSVSFDNTKQVKVGSCILNSSLFFIWWITNSDCYHLNKPEIVNFRYQYDKGIEKAICSVADRLAIDMKKKCIRRIYNYKTTGRVEYDEFYMKLSKPIINEIDKLLASHYGFTEEELDFIINYDIKYRMGDELNEE
>NC_014370.1|WP_013263858.1|1592518_1593172_+|DUF4145-domain-containing-protein
MNQKYVTPARDKDAFTCPHCHTLSLMKFRWHRHDEDVHFVTQRVGYGEYLNQLFIARCVNCGKKIIWINDDYIYPDIVAEDPNVDMPESVKQLYNEAGTIYNKSPRAACALLRLAIDRLCNELGETDRDINKNIGVLVKKGLPQAVQQALDVVRVVGNKAVHPGVISFDVDDKGTATMLMRLLNIITERMITEPKEIESLYEGLPETVKESVTKRDK

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1223993 : 1232463

Catovirus(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013263813.1\|1223993_1224803_+	TerB family tellurite resistance protein	A0A1V0SBY2	Catovirus	1.4e-05	51.8
WP_013264667.1\|1224890_1225637_+	peptidylprolyl isomerase	A0A076FI46	Aureococcus_anophage	1.3e-05	32.4
WP_044045885.1\|1225742_1226084_-	TM2 domain-containing protein	A0A1B0T6B3	Bacillus_phage	1.4e-07	50.8
WP_050759749.1\|1226144_1226513_-	DUF2752 domain-containing protein	NA	NA	NA	NA
WP_036924459.1\|1226529_1226808_-	CD225/dispanin family protein	NA	NA	NA	NA
WP_013263980.1\|1227759_1228827_+	agmatine deiminase family protein	M1I5R4	Acanthocystis_turfacea_Chlorella_virus	2.8e-43	29.3
WP_013264962.1\|1228914_1229799_+	carbon-nitrogen hydrolase	M1H5W0	Paramecium_bursaria_Chlorella_virus	5.4e-56	38.8
WP_044045886.1\|1230340_1230727_+	hypothetical protein	NA	NA	NA	NA
WP_013264855.1\|1231425_1232463_-	aspartate--ammonia ligase	A0A1C9C5F0	Heterosigma_akashiwo_virus	3.8e-53	38.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_014371

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

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2. NC_014370

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection