CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_014376	[Clostridium] saccharolyticum WM1, complete sequence	9 crisprs	DEDDh,csa3,DinG,WYL,cas3,casR	1	1	5	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_014376_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014376_1

606458-606555

Orphan

Consensus_repeat	Method
GGCTCTTTGTCAACAGTTGGGGTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014376_1

>merge|NC_014376|1|606458-606555|CRISPRCasFinder
GGCTCTTTGTCAACAGTTGGGGTGAGATTCATCTGAATCTCGCTCCGCTCTTGCATTTAGAGCTTATTTATTAAGGCTCTTTGTCAATAGTTGGGGTG

>NC_014376|1|1|606458-606555|CRISPRCasFinder
GGCTCTTTGTCAACAGTTGGGGTG	AGATTCATCTGAATCTCGCTCCGCTCTTGCATTTAGAGCTTATTTATTAA
GGCTCTTTGTCAATAGTTGGGGTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_014376.1\|WP_041708413.1\|610545_611268_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224057
NC_014376.1\|WP_013271278.1\|617189_620165_+\|hypothetical-protein	unknown	unknown	unknown
NC_014376.1\|WP_013271271.1\|608599_609742_+\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340837
NC_014376.1\|WP_013271272.1\|609735_610524_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224596
NC_014376.1\|WP_081442996.1\|606623_606899_+\|hypothetical-protein	unknown	unknown	unknown
NC_014376.1\|WP_013271260.1\|593949_595146_+\|TolC-family-protein	unknown	unknown	gnl\|CDD\|273830
NC_014376.1\|WP_013271266.1\|599676_600522_-\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|271191
NC_014376.1\|WP_013271274.1\|611282_612419_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340839
NC_014376.1\|WP_013271262.1\|595871_596936_+\|D-alanine--D-alanine-ligase	unknown	unknown	gnl\|CDD\|234993
NC_014376.1\|WP_013271268.1\|601618_603331_+\|cell-wall-binding-protein	unknown	unknown	gnl\|CDD\|227588
NC_014376.1\|WP_081442998.1\|616618_616888_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NC_014376.1\|WP_049791693.1\|607319_608603_+\|sugar-transferase	unknown	unknown	gnl\|CDD\|274398
NC_014376.1\|WP_013271269.1\|604854_606399_+\|polymerase	unknown	unknown	unknown
NC_014376.1\|WP_013271275.1\|612423_613593_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340839
NC_014376.1\|WP_013271261.1\|595126_595774_-\|stage-II-sporulation-protein-R	unknown	unknown	gnl\|CDD\|378205
NC_014376.1\|WP_013271265.1\|598382_599603_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|379114
NC_014376.1\|WP_013271276.1\|613691_616031_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340839
NC_014376.1\|WP_013271267.1\|600528_601389_-\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|271191
NC_014376.1\|WP_013271264.1\|597893_598340_+\|DUF1934-domain-containing-protein	unknown	unknown	gnl\|CDD\|378129
NC_014376.1\|WP_013271263.1\|597061_597880_+\|glutamate-racemase	unknown	unknown	gnl\|CDD\|234851

Protein	Function_ID	Function_description	E-value
NC_014376.1\|WP_041708413.1\|610545_611268_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224057	COG1134, TagH, ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane].	1.17543e-104
NC_014376.1\|WP_013271271.1\|608599_609742_+\|glycosyltransferase-family-4-protein	gnl\|CDD\|340837	cd03808, GT4_CapM-like, capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.	6.35559e-88
NC_014376.1\|WP_013271267.1\|600528_601389_-\|tyrosine-type-recombinase/integrase	gnl\|CDD\|271191	cd01191, INT_C_like_2, Uncharacterized site-specific tyrosine recombinase, C-terminal catalytic domain. Tyrosine recombinase (integrase) belongs to a DNA breaking-rejoining enzyme superfamily. The catalytic domain contains six conserved active site residues. The recombination reaction involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.	6.36978e-100
NC_014376.1\|WP_013271260.1\|593949_595146_+\|TolC-family-protein	gnl\|CDD\|273830	TIGR01845, Outer_membrane_protein_OprM, efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family. Members of this model comprise a subfamily of the Outer Membrane Factor (TCDB 1.B.17) porins. OMF proteins operate in conjunction with a primary transporter of the RND, MFS, ABC, or PET systems, and a MFP (membrane fusion protein) to tranport substrates across membranes. The complex thus formed allows transport (export) of various solutes (heavy metal cations; drugs, oligosaccharides, proteins, etc.) across the two envelopes of the Gram-negative bacterial cell envelope in a single energy-coupled step. Current data suggest that the OMF (and not the MFP) is largely responsible for the formation of both the trans-outer membrane and trans-periplasmic channels. The roles played by the MFP have yet to be determined. [Cellular processes, Detoxification, Transport and binding proteins, Porins].	0.001961
NC_014376.1\|WP_013271266.1\|599676_600522_-\|tyrosine-type-recombinase/integrase	gnl\|CDD\|271191	cd01191, INT_C_like_2, Uncharacterized site-specific tyrosine recombinase, C-terminal catalytic domain. Tyrosine recombinase (integrase) belongs to a DNA breaking-rejoining enzyme superfamily. The catalytic domain contains six conserved active site residues. The recombination reaction involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.	3.93903e-99
NC_014376.1\|WP_013271272.1\|609735_610524_+\|ABC-transporter-permease	gnl\|CDD\|224596	COG1682, TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane].	1.94128e-53
NC_014376.1\|WP_013271262.1\|595871_596936_+\|D-alanine--D-alanine-ligase	gnl\|CDD\|234993	PRK01966, ddl, D-alanine--D-alanine ligase.	3.43569e-155
NC_014376.1\|WP_013271268.1\|601618_603331_+\|cell-wall-binding-protein	gnl\|CDD\|227588	COG5263, COG5263, FOG: Glucan-binding domain (YG repeat) [General function prediction only].	5.00219e-11
NC_014376.1\|WP_081442998.1\|616618_616888_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	1.26898e-06
NC_014376.1\|WP_013271274.1\|611282_612419_+\|glycosyltransferase	gnl\|CDD\|340839	cd03811, GT4_GT28_WabH-like, family 4 and family 28 glycosyltransferases similar to Klebsiella WabH. This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.	1.81319e-43
NC_014376.1\|WP_013271276.1\|613691_616031_+\|glycosyltransferase	gnl\|CDD\|340839	cd03811, GT4_GT28_WabH-like, family 4 and family 28 glycosyltransferases similar to Klebsiella WabH. This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.	3.42646e-50
NC_014376.1\|WP_013271275.1\|612423_613593_+\|glycosyltransferase	gnl\|CDD\|340839	cd03811, GT4_GT28_WabH-like, family 4 and family 28 glycosyltransferases similar to Klebsiella WabH. This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.	2.15234e-58
NC_014376.1\|WP_013271261.1\|595126_595774_-\|stage-II-sporulation-protein-R	gnl\|CDD\|378205	pfam09551, Spore_II_R, Stage II sporulation protein R (spore_II_R). SpoIIR is designated stage II sporulation protein R. A comparative genome analysis of all sequenced genomes of Firmicutes shows that the proteins are strictly conserved among the sub-set of endospore-forming species. SpoIIR is a signalling protein that links the activation of sigma E to the transcriptional activity of sigma F during sporulation.	8.87149e-73
NC_014376.1\|WP_013271265.1\|598382_599603_-\|ATP-binding-protein	gnl\|CDD\|379114	pfam13304, AAA_21, AAA domain, putative AbiEii toxin, Type IV TA system. Several members are annotated as being of the abortive phage resistance system, in which case the family would be acting as the toxin for a type IV toxin-antitoxin resistance system.	4.13521e-17
NC_014376.1\|WP_049791693.1\|607319_608603_+\|sugar-transferase	gnl\|CDD\|274398	TIGR03025, EPS_sugtrans, exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase. Members of this family are generally found near other genes involved in the biosynthesis of a variety of exopolysaccharides. These proteins consist of two fused domains, an N-terminal hydrophobic domain of generally low conservation and a highly conserved C-terminal sugar transferase domain (pfam02397). Characterized and partially characterized members of this subfamily include Salmonella WbaP (originally RfbP), E. coli WcaJ, Methylobacillus EpsB, Xanthomonas GumD, Vibrio CpsA, Erwinia AmsG, Group B Streptococcus CpsE (originally CpsD), and Streptococcus suis Cps2E. Each of these is believed to act in transferring the sugar from, for instance, UDP-glucose or UDP-galactose, to a lipid carrier such as undecaprenyl phosphate as the first (priming) step in the synthesis of an oligosaccharide "block". This function is encoded in the C-terminal domain. The liposaccharide is believed to be subsequently transferred through a "flippase" function from the cytoplasmic to the periplasmic face of the inner membrane by the N-terminal domain. Certain closely related transferase enzymes, such as Sinorhizobium ExoY and Lactococcus EpsD, lack the N-terminal domain and are not found by this model.	6.23714e-98
NC_014376.1\|WP_013271264.1\|597893_598340_+\|DUF1934-domain-containing-protein	gnl\|CDD\|378129	pfam09148, DUF1934, Domain of unknown function (DUF1934). Members of this family are found in a set of hypothetical bacterial proteins. Their precise function has not, as yet, been defined.	1.91333e-41
NC_014376.1\|WP_013271263.1\|597061_597880_+\|glutamate-racemase	gnl\|CDD\|234851	PRK00865, PRK00865, glutamate racemase; Provisional.	2.43255e-119

>NC_014376.1|WP_013271269.1|604854_606399_+|polymerase
MEKQEGKSPFLSLVISIYVLLIGVGIPIVVRDRYFDILIVKYYFYCACTILMTILVAGHFIVTGARQRIFNIKSFFLNSLKSCTIADYAVLIYLLVAIISTFSSDYLYESFWGNEGRYTGLFLTIWYVISYFCVSRYWKFKNWYIDVILAAGMLVCLFGITDYFKLDIFHFKIAMIEEQRSIFTSTIGNINTYTAYVGILVAISTVLFATDRKIKNMMWHYFCMVISFFAIIMGVSDNAYLSLGVLFGFLPLYLFKNVKGIQRYIIILATFFSVIQCIDWINNYFGESVLGIQSAFDVFIRFRGLLYLVMLLWGIAILSHIIAYKSKLDSDKLGKIFRYLWIAILLLIILSVLYVLYDCNVSGNANRYGNLSSYFLFNDDWGTSRGYIWRKGMECYQSLPLWKKIVGFGPETFGILVMQKTVNNPYNQLYDSAHNEYLHLLTTVGFAGLTAYFVFIFGYIRRCLHYINRTPYIVAIMFGVICYSVQAFVNLNLPIVTPIFWLLLGMGAVKSMEE
>NC_014376.1|WP_013271268.1|601618_603331_+|cell-wall-binding-protein
MRKQTKLVAVLSTAALLALGASMSSFAATGWQEENGTWVYYDKNGDTVTEKWAKSGDNWFYLNEDGEMATDALVEYNDNYYYVDENGSMVANKWVSIENDNYDGDDDNEPVNHWYYFGANGKAYKSSSSSNTASFKTINGKKYIFDDEAKMLYGWINESGQRETGDDAWRTDNSLYYCGDENDGAQANGWVFLHITDNQWESTEDIGVSSKNTFDDEEQDRWFYFKGNGKKMVDKKGETINGKKYSFDEDGRMNAEWVNWDATPTTATATQGTAAYTKGFRYYGSPEDGARVTKGWFQVVPDSYLSEDDYNDDSENWYYSDKDGKLVAGEMKTINGKKYAFNNSGVMLDGFRFIKLASDNKTISAIANKDTKDEPTVKLVSDSDYKFDTTDGFKKHASSWEASDYKLYYFGSGDDGSMKINKQNVDIDGDSHSFLFNKSGSFKGAGKTGIDNKKYYQSGMLMAADKDDKYAVVKVNKTGSNVNYVQIMTTDEFLKDMEDNFNVVSVVTDTNKYSEEYTIPAAVTDSATVEYRVVNTSGTVQKSKSKAKDGNDRCYEVASNGNIVRVFVEN
>NC_014376.1|WP_013271267.1|600528_601389_-|tyrosine-type-recombinase/integrase
MTTNAVTCSEAENKSPVEQSLDDFHDYLEFNNMSSNTIHVYLYAVKQFLGLYHVISHDNLMLYKCYLMEHYKPQTVNLRIRALNCYMESLKLSSSKMLMIRIQQKTFLENVISQADYEYLKKCLIRSGNMLYYFVIRFMAATGVRVSELVQIKVEHVKCGHMDIYSKDNKIRRIYIPKSLRVDALKWLNQIDRVSGYVFLNRYGDPITPAGIRGQLKKFTVLYDLDPNVVYPHSFRHRFAKNFIENCGDISMLSDILGHESIETTRIYLHRSSTEQKQIVNQIVNW
>NC_014376.1|WP_013271266.1|599676_600522_-|tyrosine-type-recombinase/integrase
MENEELLNDYKKFLKKKNLSNNTITAYEGSVRLFFSLNKEITPESLQRYKNYLISHYRPATVNQRIHAMNHYSRFLTETSGEEYTFIASYHLPSVKVQQKTFMDSVISNEDYELLKGKLKEEKNYFWYFIVRFLAATGARVSVLVQIKVEHLNLGYLDLYSKGGKVRRIYFPDSLCQEALEWCHDKDKRSGFLFLNKDGRLITPRGINSQLKHLAKRYGIDPDTVYPHSFRHRFAKNFLACFNDISLLADLMGHESIETTRIYLTRSSQEQQQLLDEIITW
>NC_014376.1|WP_013271265.1|598382_599603_-|ATP-binding-protein
MIISFRFKNFRSFLDETYIDMKAVNYKEHPDHLVKAGNKKLIKTLAVYGANSSGKTNLFLAFTSFHSFIFWQLFSMEDIPRKHFMSLLQISSLDKILPFLDEETNTQPTEMELSFISGQRVYEYGFSVLNRKILTENMAVDNHVVFTRNEDEITIGRQYEKVLRQKAGIHPHQDRLFCSILSCLDIPEITAFMEPFETFFSKQIAYYCDFLEPFQLAGHLIMDGRVYKALENPDALNYALAQLRKLGIPAEEFIVDKGVPKLGYLVKSRDTGQYRMQYMDYTKVSLGTMKYLQLFIQVYHLSQRGGVLIIDNISNEFHPAVIKFFIDTFQQDKNINIQILFTTYDISILNNQQFRRDEVAFVDMNEYHESRLYTLADIKVRSDASFSKDYLLGKYGAIPLLKECFP
>NC_014376.1|WP_013271264.1|597893_598340_+|DUF1934-domain-containing-protein
MTRDVLISISGMQIAEDDSNSVEMITAGDYFLKNGNHYILYDEIQEDTGGVTRNTIKIRQSGLDIIKRGTSSVHMTFEKDKKNMSCYATPFGELMIGISTKDILIDEEEDRLKVRVAYSLDINYQHVSECNIVLDIHSKATADFRLLN
>NC_014376.1|WP_013271263.1|597061_597880_+|glutamate-racemase
MADRNSPIGVFDSGVGGLTVAREIMRQMPDERIVYFGDTARVPYGSKSCSTVIRFTRQIIRFLLTQDVKAIVIACNTATACALEAVEKEVEIPIVGVIHAGARTAVDSTKNGKIGIIGTEGTIRSGVYTRVMKEMREDIDVTGKPCPLLVPLVEEGLLHDSVTDEIASRYLSELKGKYIDTLVLGCTHYPLLRSTVGRLMGPEVTLVNPAYETALELKQILEGKDLLCGQESNDVEKYHFYVSDLAEKFTSFAASILPGQVKETKQINIEEY
>NC_014376.1|WP_013271262.1|595871_596936_+|D-alanine--D-alanine-ligase
MGRKTAVVLFGGQSSEHIVSCMSVVNVINHIDREKYEVALIGITEEGRWIKTDSVEDIETGTWKNGTVSAVISPDATMGGIILLDGEKTEVLKADVVFPVLHGLLGEDGTVQGLLELARIPYVGCGVLSSAVSMDKLYTKIIVDDLGVTQAAYVPVMRHDLKDMDLVVGKVEERFSYPVFVKPSNAGSSKGVSRAEDRKELMEALTEAAVHDRKILVEEMIVGREIECAVFGGGNLPAEASGVGEILAAAEFYDFDAKYYNSDSRTVVDPVLPEGAAERVKEAAKAIFQAVDGYGLARVDFFVKEDGSVVFNEINTMPGFTAISMYPMLWEAAGMNKDELVGRLMEHAMDRYRL
>NC_014376.1|WP_013271261.1|595126_595774_-|stage-II-sporulation-protein-R
MKQKRDLCLCITCFLIAFLLTLSGGRREEEALAARIAPEILRFHVLANSDRSDDQNLKLKVRTMLLNSIYEELGEKASLEETKSYVLSHKDSLEKKAEHYMKKLGYDYPAHMELTNCYFPTKTYGDMVFPCGNYEAVRVKIGEGKGRNWWCVLYPPLCFTDSSYAVVPDTSKEILRSSMDESDYKRISRESPKIHIRFKLAELLSSKPKPTVPKN
>NC_014376.1|WP_013271260.1|593949_595146_+|TolC-family-protein
MRKKGYLPACMAVTLALSSALPVYGAAGPGQTVISIPAGMTEEQWNKLQDQTIEFEELSDRVRYFNPDLQNIVDSAGNEKSNQQYVYDEMKIYIRDLNDNAKSLKDSGAADTDAGKQAYQALKDAVKKLNNGAETLDKVIKRIDKGVNKNVDRYSKTFSSAVGQIMIGYNSALANRAMVQKVLDVSKAGYEAQTLSFQQGMATEADVLEANKGVLAAQASLEQLDNTIDGLKRSLCLMTGYPADAEIQIGGIPQLDLSHISSLNLEADTAMALGNNYTLIEKRHGGSGRTTTGVKNKEASLSEEEQNVTVAMQSYYQGILQAKSAYDAACTSYEKAVLEKNKADRSYRLGMVSKLGYLQSQMAFLQAEGAKESAYNTLYQAYDTYRWAVEGIINSSEQ
>NC_014376.1|WP_081442996.1|606623_606899_+|hypothetical-protein
MGYIWRNAMVCFSGFPLWKKLVGFGQETFGILLMHQTKGNIYNEIFDSAHNEYSQYLLTIGIAGLISYVAFILACIKNCIRHKVENPLMIA
>NC_014376.1|WP_049791693.1|607319_608603_+|sugar-transferase
MVMGLGSIYAYVWIEYYNKHVIQLGFYRRGNWMIVLLYCILLMFFFNTYGGFKVGQLRFGNLLYSQILSTIFANVFTYFQIALIDKRFVNPAYMFIMTVCDIAFMITWTILFHAFYKSIFPPRKMLLISGDKSDYHLLEKMNARDDKYQICKLINYREGVEKIQAEIVKYDGVIIGDMPSNDRNWILKYCFQEAIRSYSVPKISDILLRSSDEMNLFDSPLLLSRNFGLTIEQQFLKRCLDISIALVGIILCSPIFLFIALGIKISDRGPVFYTQTRLTLNGNKFKIYKFRTMIQDAEALSGPRLAKEEDDRIFPLGAFLRATRMDELPQLFNIIKGDMSVVGPRPERPELAEQIIKEIPEFEYRLKVKAGLTGYAQVYGKYNTTSYDKLKLDLTYIRGYSLLLDFKLIIMTPKVLFMKESSEGVKR
>NC_014376.1|WP_013271271.1|608599_609742_+|glycosyltransferase-family-4-protein
MKKVLIVSHVSGFLPQFEMENVKILQGLGYEVHYAANFKNPQYGNDNSRLKNSDVLCHQIDFARSPFRVIQNMKAYKQMRRLLNEEKYSILHCHTPVGGAIARLASTKCKNKEMKVIYTVHGFHFFHGSPLRNWLIYYPIERILARLTDILITINDEDYKLACGFKLKRHGEVKKINGVGIEVDKFKDIFEQRYLSRDFGSDKKITFLSVGELNSNKNHRLVIEALHKSTFEKALYIICGEGSEKQNLKKLVKKYNLERQVRLIGYKKDVKSVLRQADVFIMPSFREGLSVALQEAMATGLPIIATDIRGNNELIDEGKGGWLIPSNDVETMAERMIQIENADIYSMGKYNFNKIQNYDKKMVALAMRDIYCNMLQEDLC
>NC_014376.1|WP_013271272.1|609735_610524_+|ABC-transporter-permease
MLEKTKIRIDVFLKYKNLLRELVARDIKVRYRRSVLGMLWTVLNPLLMMTVITVVFSTLFKQNIEHFPIYYLAGTLVFSFNSETTSNALYSIIGNAPLMKKVYIPKYLFPVSKTVSGLVNLGFSMIAMFIVMIILGVEFRPTLLLLPIPIFYVFLFSVGSGLFLAAITVFFRDVANFYGVFVMAWTYFTPIFFPVSILPAAAMKLIYWNPMYHYVNYMRDLILFGRFPGLKENLVCFMFGVVSLVIGVVVFYKKQDRFVLFI
>NC_014376.1|WP_041708413.1|610545_611268_+|ABC-transporter-ATP-binding-protein
MIRLDNVSMMFNMSNERIDNIKEYVIRLVKKELMFQQFWALKNISFELEKGDSLGVVGLNGAGKSTLLKLIAGVMKPTEGTVYTIGSIAPLIELGAGFDEDLSAEENIYLNGAILGYSRNYMKERYEEIIDFAELKNFTQVPLKNYSSGMKARLGFAVATMNVPDILILDEVLSVGDYKFQEKSFERTQKILNSGATVLFVSHSVSQVRKVCNKALWLDNGTVKMYDTADKVCTAYENMV
>NC_014376.1|WP_013271274.1|611282_612419_+|glycosyltransferase
MKKLLFVITQFYKGGAEVALLNLFHRLSPEEYEIDFLIFDQMILKEATSLIPQIPEWVNVCNAAEPEGHLAVVKKIWFKIYRRVTKHQLYRKRAYNFIKGKEYDAAFSYGEWMSPEFVAQKVKAKKKMVWIHADIDKAAYVDERILFGYDRAYDRYLFVSEQSRKAAEQAFLFLKGKCSVVHNMCDDQEIYRLAKEPLSVDDEAFDSYLLSVANLREEKNYPRMIETMKCLCDMGVEARWLCIGSTANVFILNKVKSLLAQYQLEDRFILLGACENPYKYMSRSKAVLVLSDFESWSLVITEAKLLGIPVVATKTSGALEQIQDRESGILVSFEPKDIANSVKELLENQEIQEKIRINLGGFSTQQKTLEEFLAILED
>NC_014376.1|WP_013271275.1|612423_613593_+|glycosyltransferase
MKKIVYVFDDINYQSGAQKAAFYQMQCLSDKYDVYAMSLSKPDEELEITATIIRQETLWEKADAYTKSFKEMLISNKGFSEKAGRIFYAISMRLGIGELFLTFFLYKKLIEELEKFDVVVVVSEASKLRNVVGGLAKPRKVQWIHTDYERWCQYSEWTRAVTKNDSCLYKKYDCIVVLSESCRQGMIRRIPQLSEKIVVIPNMVNITDIQRKSLEEAEVFITDKAYNFVTVGRLDKEKNFGRILDICKCLSADKIDYTWYVIGDGPLRESIQKQIKRLDLQENVILLGRLENPYPVMKQCDIFVLLSDYEGTPVTIDEAVVLDLPVISTPVGGIPEQLRRYGCGKLLEGTRNLYKEFTLAIDGIDEKKVVSIDIINRTIFEKMIKIVEG
>NC_014376.1|WP_013271276.1|613691_616031_+|glycosyltransferase
MKKLLFVINQLYKGGAETSLVNLLNHLDYSKYSVELLILNQCPVKDAVSLINRINKSVTVCDAYMEYQKITIFDRIRAKALYTIEQKGAYYFTALDFIKDKYYDWAFFVGEWCSPSFVAYEVEANIKAAWMHNDLSEAEYFDAEHYFYFADMFDYFIFVSKHSLDSSVAAFPFLKKKAVTIYNINDIDYIRKRAEEQSDYKIENNKLMVLTCANFRPQKNHLRQIEVMVELKKRGVEFVWVNIGATSDEGLVSRVKEIRDENQLTDQFLIFGPKENPYSYMKQADIVAVLSDYESWSMVITEAKILGKPIIATKTSGAVEQIEDKRTGILTDFSVSDITDCLEALLNNEKVREQIKNNINGFDNTKEIIDSFDELICEGVSSKENVDILYVIDDINYMGGAHIATELQIREFVKIGKKVAIYSSNVPNLEIREKLLGVNFLGLKNFKENTIFTSRLTYCLFSPKLTKEERMRKLRYTVSSYLKKFNYNEMVLPKITILFSKYPTICVISEASLYRKAIAESNCEIKIQWIHTDYCEWKDKNDWTKKITLNDAKLYQKFTTIVVLTDNIKAKFVKLYPHLESKIIVNKNLIPVDEIKEKSKPLSPKNRKPVHFVTIGRISFEKSYPRLIKILSRLKGEGYLFTWTIVGGGEDFERVKLLISTSGLQDEVTMTGPLSNPFRILKESDVFALLSDYEGLPNTIYEALVLGVPVLATNVGGISTQITDGENGWLVENNERKIESMLETILMNQERIDALKENLKSYIYDNDKVIEINKKIFHI
>NC_014376.1|WP_081442998.1|616618_616888_+|class-I-SAM-dependent-methyltransferase
MCSAIEIGCGDGNQLSQIKYKRYVGVDVSQTIIEQNRVKFKDDNSKQLFCALTERALYIDNRYELAISMDVIFHLLEESVFEKYMEGLF
>NC_014376.1|WP_013271278.1|617189_620165_+|hypothetical-protein
MKTLNYIRMGLLCILGSYYLTWRIDEITLDTWFQKIFVFIYFLLILLFFWLLRHRYLKLPPITIQEKVAKNLVSILITVVFVTVGFDAFVGWRYDPISISITALGKTGEIHVGQKGTEVWITEIKIDGQKYDLSKVPLAPEWEYRDNANLLSYQNQPSTIAFELPGARNTEIDFLSHPWSGEVLVKSNQKNQKIDLYRTEDKESSNVTFSLPGERGVSFIWDWIARIGCFILLLDIINTAICFLIWRKSIKTENSSTSSLSPPRNYQLLYILAVCMGIAFLIFRHTSIELYSKAYFALLCGAFSVLLILTGVAYFAVLKEHNVQRYNMRAFVIAIILSVFVVFLLVNNLYNLEFHPTFTAIFYLQSSLLFSLCTLTLYLSFHIMPSSLLGVMVPPFLLSIVLPLSGWLRSWTTGSLFLVTSFLFFILFFAIYVLRQKFDFKYSKIEKAVSRVKILFFVCITFFTVFLWSYNKIVLSPNKIQGGISIIGFLGISMVYAAAFGISILTLLQLFKNKISKKWITTRTIRIQKNELKVFPILLIFMILYWLIWLVAYYPANMSPDSVDQWGQAIGVSPLLDAHPIFSTLWIRMCSLLWQSPAMVILVQIISTAVILAYILNYFSLWNFNKKVLLVLGCAVALLPNSSIYVVTQWKDVVFLLALLVLAYLMQKIFMDKKIGALENIALVIALSGVSLLRHNGFLIALICGLILLIVALKKRLFYSVVSIILAATFVFLFNGPIYKALNVKHYGIGLAGTVTDCVGYTIYYDGEIPEDILEEATQTATVDFWKAQFAPFLAFDYIYNGEHNLSSIYAGKSSAEQIGIILRLFLRNPDIIFYERMAMNDTNLFINQSEAQGSLNSRYQKDIYENDFGFAHKDTTLKTLLDKFLSATSWQNPFWDSFLWRNGVMICVAAWVIYFNFTQKRWTRNIIFLPMIINFLTLFIALVEQSYRFTHNIVPYLLIAILFAVMPDEADEQTNMVFERKHKSKKQVRV

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Crispr_ID: NC_014376_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014376_2

649843-650274

Orphan

Consensus_repeat	Method
GCCGCAGGAAACAGCAATNGCCAGGGA	CRT

9 spacers

The CRISPR arrays of NC_014376_2

>merge|NC_014376|2|649843-650274|CRT
ACTTCAGGAAACAGCAATAGCCAGAGAACATCAGGAAGCCGCAGTGCTTCAGGAAACAGCAGCAGCCAGGGACCAACAGGAAGCCGCAGTACTTCAGGAAACAGCAGCAGCCAGGGAGCAACAGGAAGCCGCAGTGCCGCAGGAAACAGCAATGGCCAGGGAACTCTGGGAGGCCGCAGTGCCGCAGGAAGCAGCAATGGCCAGGGAATACCGGGAAGCCGCAGTGCCGCAGGAAACAGCAATGGCCAGGGAGCAACAGGAAGCCGCAGTGCCGCAGGAAACAGCAATGGCCAGGGAACTCTGGGAGGTCGCAGTGCCGCAGGAAACAGCAATGGCCAGGGAGCAACAGGAAGCCGCAGTGCCGCAGGAAACAGCAATGGCCAGGGAATACCGGGAAGCCGCAGTGCCGCAGGAAACAGCAGCCGCCAGGGC

>NC_014376|2|1|649843-650274|CRT
ACTTCAGGAAACAGCAATAGCCAGAGA	ACATCAGGAAGCCGCAGT
GCTTCAGGAAACAGCAGCAGCCAGGGA	CCAACAGGAAGCCGCAGT
ACTTCAGGAAACAGCAGCAGCCAGGGA	GCAACAGGAAGCCGCAGT
GCCGCAGGAAACAGCAATGGCCAGGGA	ACTCTGGGAGGCCGCAGT
GCCGCAGGAAGCAGCAATGGCCAGGGA	ATACCGGGAAGCCGCAGT
GCCGCAGGAAACAGCAATGGCCAGGGA	GCAACAGGAAGCCGCAGT
GCCGCAGGAAACAGCAATGGCCAGGGA	ACTCTGGGAGGTCGCAGT
GCCGCAGGAAACAGCAATGGCCAGGGA	GCAACAGGAAGCCGCAGT
GCCGCAGGAAACAGCAATGGCCAGGGA	ATACCGGGAAGCCGCAGT
GCCGCAGGAAACAGCAGCCGCCAGGGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_014376.1\|WP_041708420.1\|638128_638347_-\|hypothetical-protein	unknown	unknown	unknown
NC_014376.1\|WP_013271305.1\|653588_654572_-\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380514
NC_014376.1\|WP_013271301.1\|646918_647908_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133029
NC_014376.1\|WP_013271307.1\|656389_657301_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NC_014376.1\|WP_085952055.1\|660642_661530_+\|adenylylsulfate-kinase	unknown	unknown	gnl\|CDD\|366715
NC_014376.1\|WP_041708418.1\|637485_637974_-\|hypothetical-protein	unknown	unknown	unknown
NC_014376.1\|WP_013271306.1\|654887_656243_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270303
NC_014376.1\|WP_013271302.1\|648006_649425_+\|undecaprenyl-phosphate-glucose-phosphotransferase	unknown	unknown	gnl\|CDD\|274396
NC_014376.1\|WP_013271313.1\|661519_663223_+\|glycosidase	unknown	unknown	gnl\|CDD\|200492
NC_014376.1\|WP_013271309.1\|658164_659010_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|179371
NC_014376.1\|WP_013271299.1\|643720_644728_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133030
NC_014376.1\|WP_013271311.1\|659817_660519_+\|tyrosine-protein-phosphatase	unknown	unknown	gnl\|CDD\|379135
NC_014376.1\|WP_013271308.1\|657300_658155_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_014376.1\|WP_013271295.1\|638480_640415_+\|thiamine-pyrophosphate-binding-protein	unknown	unknown	gnl\|CDD\|223107
NC_014376.1\|WP_013271304.1\|652066_653539_+\|trypsin-like-serine-protease	unknown	unknown	gnl\|CDD\|273938
NC_014376.1\|WP_013271296.1\|640443_641382_+\|NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223528
NC_014376.1\|WP_013271310.1\|659023_659794_+\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|223695
NC_014376.1\|WP_013271298.1\|642648_643716_+\|zinc-binding-dehydrogenase	unknown	unknown	gnl\|CDD\|176245
NC_014376.1\|WP_013271300.1\|644724_646917_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133027
NC_014376.1\|WP_013271297.1\|641445_642639_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|372616

Protein	Function_ID	Function_description	E-value
NC_014376.1\|WP_013271305.1\|653588_654572_-\|LacI-family-transcriptional-regulator	gnl\|CDD\|380514	cd06291, PBP1_Qymf-like, ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs. This group includes the ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus metalliredigens (strain Qymf) and its close homologs. Qymf is a strict anaerobe that could be grown in the presence of borax and its cells are straight rods that produce endospores. This group is a member of the LacI-GalR family repressors that are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type 1 periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.	1.26186e-104
NC_014376.1\|WP_013271301.1\|646918_647908_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|133029	cd04186, GT_2_like_c, Subfamily of Glycosyltransferase Family GT2 of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.	8.75452e-56
NC_014376.1\|WP_013271307.1\|656389_657301_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	1.8483e-83
NC_014376.1\|WP_085952055.1\|660642_661530_+\|adenylylsulfate-kinase	gnl\|CDD\|366715	pfam01583, APS_kinase, Adenylylsulphate kinase. Enzyme that catalyzes the phosphorylation of adenylylsulphate to 3'-phosphoadenylylsulfate. This domain contains an ATP binding P-loop motif.	0.00910693
NC_014376.1\|WP_013271306.1\|654887_656243_+\|extracellular-solute-binding-protein	gnl\|CDD\|270303	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold. This family includes the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.7656e-29
NC_014376.1\|WP_013271302.1\|648006_649425_+\|undecaprenyl-phosphate-glucose-phosphotransferase	gnl\|CDD\|274396	TIGR03023, Sugar_transferase., Undecaprenyl-phosphate glucose phosphotransferase. This family of proteins encompasses the E. coli WcaJ protein involved in colanic acid biosynthesis, the Methylobacillus EpsB protein involved in methanolan biosynthesis, as well as the GumD protein involved in the biosynthesis of xanthan. All of these are closely related to the well-characterized WbaP (formerly RfbP) protein, which is the first enzyme in O-antigen biosynthesis in Salmonella typhimurium. The enzyme transfers galactose from UDP-galactose (NOTE: not glucose) to a polyprenyl carrier (utilizing the highly conserved C-terminal sugar transferase domain, pfam02397) a reaction which takes place at the cytoplasmic face of the inner membrane. The N-terminal hydrophobic domain is then believed to facilitate the "flippase" function of transferring the liposaccharide unit from the cytoplasmic face to the periplasmic face of the inner membrane. Most of these genes are found within large operons dedicated to the production of complex exopolysaccharides such as the enterobacterial O-antigen. Colanic acid biosynthesis utilizes a glucose-undecaprenyl carrier, knockout of EpsB abolishes incorporation of UDP-glucose into the lipid phase, and the C-terminal portion of GumD has been shown to be responsible for the glucosyl-1-transferase activity.	0
NC_014376.1\|WP_013271313.1\|661519_663223_+\|glycosidase	gnl\|CDD\|200492	cd11355, AmyAc_Sucrose_phosphorylase, Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase). Sucrose phosphorylase is a bacterial enzyme that catalyzes the phosphorolysis of sucrose to yield glucose-1-phosphate and fructose. These enzymes do not have the conserved calcium ion present in other alpha amylase family enzymes. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	3.45728e-87
NC_014376.1\|WP_013271309.1\|658164_659010_+\|hypothetical-protein	gnl\|CDD\|179371	PRK02113, PRK02113, MBL fold metallo-hydrolase.	7.76168e-16
NC_014376.1\|WP_013271299.1\|643720_644728_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|133030	cd04187, DPM1_like_bac, Bacterial DPM1_like enzymes are related to eukaryotic DPM1. A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.	8.50897e-75
NC_014376.1\|WP_013271311.1\|659817_660519_+\|tyrosine-protein-phosphatase	gnl\|CDD\|379135	pfam13350, Y_phosphatase3, Tyrosine phosphatase family. This family is closely related to the pfam00102 and pfam00782 families.	3.50393e-65
NC_014376.1\|WP_013271308.1\|657300_658155_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	4.15932e-64
NC_014376.1\|WP_013271295.1\|638480_640415_+\|thiamine-pyrophosphate-binding-protein	gnl\|CDD\|223107	COG0028, IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism].	1.22019e-128
NC_014376.1\|WP_013271304.1\|652066_653539_+\|trypsin-like-serine-protease	gnl\|CDD\|273938	TIGR02037, Probable_periplasmic_serine_protease_do/HhoA-like, periplasmic serine protease, Do/DeqQ family. This family consists of a set proteins various designated DegP, heat shock protein HtrA, and protease DO. The ortholog in Pseudomonas aeruginosa is designated MucD and is found in an operon that controls mucoid phenotype. This family also includes the DegQ (HhoA) paralog in E. coli which can rescue a DegP mutant, but not the smaller DegS paralog, which cannot. Members of this family are located in the periplasm and have separable functions as both protease and chaperone. Members have a trypsin domain and two copies of a PDZ domain. This protein protects bacteria from thermal and other stresses and may be important for the survival of bacterial pathogens.// The chaperone function is dominant at low temperatures, whereas the proteolytic activity is turned on at elevated temperatures. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides].	1.16428e-78
NC_014376.1\|WP_013271296.1\|640443_641382_+\|NAD(P)-dependent-oxidoreductase	gnl\|CDD\|223528	COG0451, WcaG, Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism].	2.95104e-42
NC_014376.1\|WP_013271310.1\|659023_659794_+\|metallophosphoesterase	gnl\|CDD\|223695	COG0622, COG0622, Predicted phosphoesterase [General function prediction only].	1.16029e-15
NC_014376.1\|WP_013271298.1\|642648_643716_+\|zinc-binding-dehydrogenase	gnl\|CDD\|176245	cd08285, NADP_ADH, NADP(H)-dependent alcohol dehydrogenases. This group is predominated by atypical alcohol dehydrogenases; they exist as tetramers and exhibit specificity for NADP(H) as a cofactor in the interconversion of alcohols and aldehydes, or ketones. Like other zinc-dependent alcohol dehydrogenases (ADH) of the medium chain alcohol dehydrogenase/reductase family (MDR), tetrameric ADHs have a catalytic zinc that resides between the catalytic and NAD(H)binding domains; however, they do not have and a structural zinc in a lobe of the catalytic domain. The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit.	2.19741e-158
NC_014376.1\|WP_013271300.1\|644724_646917_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|133027	cd04184, GT2_RfbC_Mx_like, Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis. The rfbC gene encodes a predicted protein of 1,276 amino acids, which is required for O-antigen biosynthesis in Myxococcus xanthus. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.	1.64433e-109
NC_014376.1\|WP_013271297.1\|641445_642639_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|372616	pfam13489, Methyltransf_23, Methyltransferase domain. This family appears to be a methyltransferase domain.	4.04396e-18

>NC_014376.1|WP_013271302.1|648006_649425_+|undecaprenyl-phosphate-glucose-phosphotransferase
MIKDNQKKLNGFHVVLDGLVIVLSYVIAWLLLLLGNRLFSPYKQVLRPQYYFAALLIILPVYLLLYGIFHLYAPKRVQERRYEFANICKANLLGVLLFALILLLAKKNPYFNEFSRRLVFYFCAINITLEAAVRNMLRSILRSMRSKGYNQKHILLIGYSRAAEGFIDRVRLNPEWGYQVKGILDDTKEWGTGYKGINVIGKIHDLDEILGLNSLDEIAITLSINEYANLEGIVASCEKSGVHTKFIPDYNNMIPTRPFIEDLQGLPVVNIRRVPLTDTVNALVKRLVDILGASVALILFSPVMLITAVLIKLTAPGPLIYKQERVGLHNRPFPMYKFRSMVVQTASEEKTKWTTPHDSRVTPVGRFIRKTSIDEMPQFVNVLRGDMSLVGPRPERPLFVEKFKEEIPRYMIKHQVRPGITGWAQVNGYRGDTSITKRIEHDLYYIENWTLGFDFKILFLTMFKGFINKNAY
>NC_014376.1|WP_013271301.1|646918_647908_+|glycosyltransferase-family-2-protein
MEKKVTVVIPNYNGLKFMEPCFKALEAQSDKNFELLVVDNGSTDGSVEWLKEKNIPSVFLGENTGFSGAVNVGIRQAKTPYVILLNNDTEPEPDYVKELVRAMDRSPKIFSASSKMIQRYHKELMDDAGDMYSILGWAYQRGVGQSSKGYGKARRVFAACAGAAIYRREVFEEIGGFDEAHFAYLEDIDVGYRAKIYGYENLYCPAAVVYHVGSGTSGSKYNSFKVRLAARNNIYLNYKNMPVFQLLVNFLPILAGIFVKYLFFRKIGFASDYAEGLKEGLRTAKKTRKVRFRMAHLGNYFRIEGELILGTFLYIWEFLRRKLKIFRSY
>NC_014376.1|WP_013271300.1|644724_646917_+|glycosyltransferase-family-2-protein
MKYKIDVARIRENSIVLNGWVIGKSLQSEAEFQVLDGQEKSVEFKYVPVRRDDVCQIYFKKAADRDLGFDIRIPYIREKNEDRILVIRCDGKTARVKLNARIIEKQNSSAHKKSAKLKSMMNVQTFQSAVDFWRENGFKAFVLKSRHKLQGIDSDYDYPEWYALTKTTDEELDVQRKTAFDYMPKMSVVIPAYKTPERYLSAMLDSLLAQTYGNWEVCIADGSPKGEGVERVLKRYAIKDERIRYVILGENKGIAGNTNAAMEMAKGDFIVLADHDDTLAPDALFECVKVINSDPEIDVVYTDEDKLDIDGGELFEPHFKPDFNPDLLTSVNYICHLFVVNQELLTEVGGFREEYDGAQDYDFIFRCTEKARRIYHIPKALYHWRCHQNSTASNPESKLYAFEAGARAIKAHYERMGMEALSVEKGIDYGIYHTIFKINGEPLVSIIIPNKDHSADLDLCIRSIIEKSTYKNLEFVVVENNSTDPETFGYYERIQNEFGFIRVVKWEREFNYSAINNFGVAHAKGEYLLFLNNDTEIINPESIHEMLGFCQRDDVGIVGVRLLYSDDTIQHAGVVVGFGGIAGHTFIGLHKAESSYFNQAMCARNYSAVTAACMMSKKSLFEKAGGFSEDLAVAFNDIDYCMKIRSLNKLVVYAPYALFYHYESKSRGLEDTPEKVARFNQEIKKFSQKWPEILRDGDPYYNPNLTLRKSNFALRDLRKEKIGEPYELEV
>NC_014376.1|WP_013271299.1|643720_644728_+|glycosyltransferase-family-2-protein
MKTISIVIPCYNEEENVNAMYQAIDRIFKSDLPDYSYELIFIDNDSRDRTREIVRSLCSQDKKVKGIFNAKNFGQFNSPYYGMLQSGGDCTILMAADFQDPVEMIPKYVKEWEKGYKIVIGIKKSSKENKLMYWLRTCYYKTIKKLSDVEQIEHFTGFGLYDETFIKVLRELDDPTPFLRGIVAELGFRRREIPYEQPKRRAGKTSNNFYRLYDAAMLSVTSYTKVGLRLATIFGSICSFASMMVALIYLVMKLVYWDRFPAGMAPLLIGMCFLGSVQIFFIGLVGEYVLSINARVMKRPLVIEEERINFTEKTDNKSEEGILLMTASMEAGDQR
>NC_014376.1|WP_013271298.1|642648_643716_+|zinc-binding-dehydrogenase
MKAFVLIEPGKAGWYDAPEPTVTPYGAILRPIAVTPCSSDVHTVYGGGSRKAPNLILGHECVAEVLETGELVCDFAPGDLVVVPAITPDWRALGIQEGNFKHASAPFSGHQLGRSVPGVFAEKFLIPDADTTLAKIPEGITLEQALMCVDVVTTGFTGAESADIKIGDTLVVLGIGPIGLMAVEGARHLGAARILAVGSRPVCVKLAREFGATEVLSYKDGNVTDQVMERTGGLGADGVIICGGGDEVFAQAVDMARYGIGTISNVNYYGGTGSLPFPKFSGGRGMAGKTIHTELAKGGRVRMERLLKMVQYGRINPEKLVTHCLYGLDQVETALQLMKEKPEDLIKVMVRIDWK
>NC_014376.1|WP_013271297.1|641445_642639_+|methyltransferase-domain-containing-protein
MRDKICIVCGRPLGEKPLMFLGDMPASAQDIPVRDELEEEHGITLSLHQCKSCGLVQFDCEPVAYYKDVIRSGGFTTTMVNLRRGQYRHFIETYHLEGKKLIEAGCGQGEFLSVLSEFPVKAYGIENRESLVRLAREKGLTVWKQFAKEGEVLAPDDGSASGPYDGFLSFNFLEHQPDPVGMLRCIADNLSVDGVGLITVPSLEYILQYDGYYELIRDHLAYYTFDTLGYAVEKAGFEVLEKEMVNRDTLSVIVRKRKQTSRPAKAAGPQTAVDISGLKESLDTIGREMEELAEELHGRGKKLAIWGASHQGFTLASTTAIGRFARYIIDSAPFKQGKFAPSSHLPIVSPDHFPADPVDAILIVAPGYTDEIAGIIKEKFGRNVEILALKSNHLERI
>NC_014376.1|WP_013271296.1|640443_641382_+|NAD(P)-dependent-oxidoreductase
MNVVVTGATSFLGRALVDRLLKEKHQVFAVVRPGSRNVESLGLKRPGLIRIERNLEDLHELVQVIHEPCQSFYHFGWDGSGSENRMKREVQQKNVEDSLKALEGARRLGCRRFLFSGSQAEYGIHKEAMTEGSECRPVSEYGRAKLDFLERARSMTESWRKTGISEMEYIHSRIFSIYGPGDHPWSLVESCLKAFGAGEYISLGECTQIWNFLYLDDCIRALILLMEQEKGSVSGVYNVAAPEGENRPLKDYIRTMYEVLGSHGSYSFGRRKPNAEGPANLIPDIKKLEKTTGWQPFVSFQEGIRKTYEAEG
>NC_014376.1|WP_013271295.1|638480_640415_+|thiamine-pyrophosphate-binding-protein
MRMKVSNYISQKLVDSGITQVFTVTGGGAMHLNDALGHQEGMHCLYNHHEQACAIAAEAYARIQGRIAAVCVTTGPGGTNAITGVLGGYLDSIPMLILSGQVRYDTTARWSGVGIRAMGDQEFDITKAVDCMTKYSEMVVDPMRIRYTLEKAIYLAFSGRPGPAWLDIPLDVQGAYIETEELAGFSAEDYEKGGDGWAGDHEAKIKEDKAGYGEKRQILPEKVTAETARAILEKIKSSSRPVINAGNGIRIGQAHEVFLRIVDKLGIPVVTGWNSQDCIPDEHPLYTGRGGGMGDRAGNFAIQNSDLVLSLGSRLSIRQVGYNYTTWAREAYVIVNDIDPEELKKPSIHADMRVHAHVKDLLTALEALLDSEYKATADAPLFDRGKGLDSMTWNETCRMWKETYPVVLPKHYNDGEDGQANVYALVKELSRRLPENRITVVGNGSACVVGGHAYIIKKGQRFLSNSAVASMGYDLPAAIGACMAAQGEDIILVTGDGSIQMNLQELQTIIHHRMPVKIFLINNGGYHSIRQTQKNFFGEPLVGIGEDSRDLSFPDMEKLSAAYGYPYVCAHHNSQLENAIESALKEKGPVICEIFVSRDQNFEPKSSAKRLPDGTLISPPLEDLSPFLSDEEMDRNMIISRIRE
>NC_014376.1|WP_041708420.1|638128_638347_-|hypothetical-protein
MFALMLVWAAEPAASGTLCRLYVTLFLLRSAACKSCGFNTLYGCRDRGFWYAVQIVCHVVSAPQCSLQILRL
>NC_014376.1|WP_041708418.1|637485_637974_-|hypothetical-protein
MSRCFCSAVQPANPAALIRCMAAGTAASGTLCRLYVTLFLLRSAACKSYGFNTLYGCRDRGFWYALQIVCHVVSAPQCSLQILRLWYAVWLQGPRLLVRCADCMSHCFCSAVQPANPTALIRCMAVGTAASGTLCRLYVTLFLLRSAACKSCGFAGSQAFAL
>NC_014376.1|WP_013271304.1|652066_653539_+|trypsin-like-serine-protease
MYDENENKDTGRMNPEEHKEEAVTTNFIMRDPDSEKPGPRDSERNIRPQTYHTYEEQQNIPHYQEYQYHRAAEQSMFQEEPKTKKKGGFVKKAAGLVGAALVFGVVAGSTMVGINWAAGAYGNNNNNLEISKAETIPSSANAEGVQAANTSNITTSNDVSTIVDRAMPSVVAITSKVIYESQTWFGPMQREGVGSGSGIVVGKNDDELLIVTNNHVVQGAEELKVTFIDQAAVDASIKGTDADSDLAVIAVPLKNISSDTLSKIAIASLGNSDSLKVGQGVVAIGNALGYGQSVTVGYVSALDRSVQTEDGTSRDLLQTDAAINPGNSGGALLNMRGEVVGINSAKYSSTEVEGMGYAIPISKAQNIIDTLMTRKTRTQVTDENQGYLGIQCKNIDGVTSQQLGMPQGVFIYKIVEGGAASKSDLREKDIITKFDGQGIKTYDDLTNMLKYYEGGTTVTLTVQSLENGQYVERNVDITLGKKPADAAQKG
>NC_014376.1|WP_013271305.1|653588_654572_-|LacI-family-transcriptional-regulator
MSTLKDVAEMAGVTVTTVSRVINNRGYLSEETKQKVKQAMRELHYQPNELARSLSKQVTNTIGIITPHITHPYFAQLISQLENAASKRGFKILLCNSKEDLSREAEYIDLCKSNRVTGIIFCGMILASEQYTQQGIPFVAIECNSPLCATTILCDNYVGGRLAAEHLIACGCKNLIHFSGIIDQEMPGDSRAQAFKEVCLKHQVAFESIWTKDNTYYSMDYHDSIRQTLAKYPDTDGIFASSDLIAAQVIQVCTEMGKRIPNDIKLVGFDDVALSTLTTPQISTIHQPTKEMAEMAVDSLIKNSGKETAPSKIVLPVSLIKRQSTGQ
>NC_014376.1|WP_013271306.1|654887_656243_+|extracellular-solute-binding-protein
MKQLWKKAAVAISVLAFAVTAAGCGEKVTDTATTAVTTAAESGAENQSQAEGAKGAGSIKVWVSSGAEDDIYRDMFKKMETELNLDINDEYYPKDELDSKMQVAPVVGDAPDMIIADYLQIPSYYEAGMIENLDDRMTSNIKEDLLQSIIDESTYNGHLVTTAQFDAGMALWANKSMLEAAGVRIPVSYKEAWDKAEFEDALAKLKASGVEYPLYIRQNKPSSLYFTFMPVLASFGGDYVNRETMLTEGALDSEETIAAYSYITWLVNQGYINGACDYEDAFYGRKESALALLGHWKYTDHVTNLGDDAILVPVPDFGKGVFTCSGSVVWAMTTAAKENGTADAVWSVMEASLQPDYINQMTDFNGAIPSRKSILDSKEELKKGGRMYLYREQLEAGISVLRPLTPAHMTIYSAMEAATSDIIGGADAAETLKEASKSIDEIIVENEWNLK
>NC_014376.1|WP_013271307.1|656389_657301_+|sugar-ABC-transporter-permease
MKVQLKTGTKGGLRGGQTRTAWMFCTPALVPITLFIILPFCMSIIYSFTNRMLVQKAGKTVEFVGLKNFLKLFTNGTAQQAFLNTAVYALLVVPVIVVLGIMLAVLVNNSLKGVKLFRTIYFSPQIITMTVVAIVWSFIFSPGPDGLMNSALRLLGVQPQAWLQDSRWALFCIAVMYIWQSLGMEMLIILGGLQFISEDLYEAGRMDGCSSFQRFWYITVPMLKNTLVYVLISTTINTLKLFTQVYVLTNGGPKGSTTSVIYLLYKSGFVNNQLGYSSAIAVVFFLIVLLISLIQNRILGRDN
>NC_014376.1|WP_013271308.1|657300_658155_+|carbohydrate-ABC-transporter-permease
MRSAMSKQKKMMYLFLMYAAYLLVAFVFVAPIVYMTVSSLKTDTQIVADMSTIKAFLPVGTLSFDNFTKVIERVDFMKFFKNSAVVAVINVSLVVIVNAMIGYALGLLDFRGKNFMISLIIALSIIPTEAVVINRFMVANQLRMLNSYIGLALPTIGYPMYIFLYYNHFKGMPKELMEAAIVDGESYAGIFWRIMLPLSKPICATVTIMAFIRSWGDLLWPTLVTRDETYRTLPLALRALSTDVYIFWGQIFAFATLMTIPVFLIFLMFQKQFIQSLTMSGIKG
>NC_014376.1|WP_013271309.1|658164_659010_+|hypothetical-protein
MKLQYIGTGAAEGFPGMFCQCEACERARKAGGHNLKTRSCAIIDDQVLIDLSPDLYVQSLLLGLELGKVKDLVVTHTHKDHLDSFFLGLRARDGATKLPKIMEEENYLSVYGSSFVETAVHRALEEESYSNDSRIRFIPVETGIWFQAGRLKFCPLKANHKKDELCHIYAVTDGSGSLLYANDTGALSEETLDMVGSLGLVFDVVSMDCARGTLPGDGHMGIKENLDLKKCLEQMGCTGPNTRYYLNHLSHMSGVIHDDLQRMMRAEGFTVAYDGMAVLIG
>NC_014376.1|WP_013271310.1|659023_659794_+|metallophosphoesterase
MKLLVISDIHSNIWALDKILDTEKNFDLLCCAGDLVDYGTAPGQVVDCMRQYSSNVLVQGNHDLHAVEIWKQDQYRDVVPEKFKWVHHNCQRLDEDRIHYLEQLPLRVTFEADGYVYMIQHQFDNAYGLVESRHQFDEFWKQHAEPEYKNSKKRRMIFGHTHRQCIHVLDQDMLWLNPGSASYRRPDDPDKTAHYAVVENGEIQLRRVSYDRSHCLEEAIKLNQVHGMMKTELQDFFFFFGDAETSRDPLPLEPEK
>NC_014376.1|WP_013271311.1|659817_660519_+|tyrosine-protein-phosphatase
MMACRRYPMKGIANFRDLGGYFCKGGVTKWGVFFRSTSLHKAVKEDLAIMEQVGISRILDLRYPQERKEMPDVPVKGAEWLGISLLGTIPVEKLQVNDKEEDTRTLINMYRQIIASSRTEIRDSVKAMIDAKGPALFHCAAGKDRTGILAMLLLGAVGVSQEDIIADYEISHHYIRSFTSDISGSHGSNMYKLLNEISEQWGSVAGFLMECGISMDELSLLIEKFVMPCEFNG
>NC_014376.1|WP_085952055.1|660642_661530_+|adenylylsulfate-kinase
MPGDKVEIGEVHRKKANIIFPQLLFKLSEVLKECESEKVVVTVCGGSGVGKSEIASLLSYYFNHLGIGSYTLSGDNYPHRIPKYNDGERLHIFRESAIKAMVKDGTFNEERFKIIHRLQQVQDDANAVHTKKYSWYKSYLLGGREGLKNYLGTEKEIAFGEIEEILTQFKNGKEEIWLKRMGRDDTELWYGKVDFSGIHVMIIEWTHGNSDNYQGVDIPILLNSTPQETLAHRRARNRDGATDSPFTAMVLELEQEMLEAQAPKARIILSKSGEILTYEQYCRQMEESRGGGHEQ
>NC_014376.1|WP_013271313.1|661519_663223_+|glycosidase
MNSKEDKFSVDYGVMLNAYPDSMGGTLSQITDFLKRPELAEVFRSFYILPSIFNTDLDRGFSVIDYGLNERMADRKDLEAFKDLGIDLKLDFILNHSSVLSKEFQDILKNGEKSRYRDFFIDWNKFWEGYGTMTEEGYIQPDEALIKDMFFRKPGLPILMVRLPDGKNVPYWNTFYQEVQYKRLDQWDLMQAAEIQYAAAEDLARIVNQELQEGKKPSEIEFESYEKYRDCVVELLESGRRYLGQMDLNIRSPLVWEYYDNTLKTLSEYGAKIVRLDAFAYAPKAPGERNFLNDPGTWDLLQKVQDLADQYHLQLLPEIHSGYGEKTYELLAGKGYMTYDFFLPGLIIHALESGSGEYLTGWAKELKVKKIKVVNMLGCHDGIPLLDLKGLIPDEEIEGLIKTIVGRGGFVKNLHGQKNVYYQVNATYYSALGEDDKKMLLSRALQLFMPGKPQVWYLDLFAGKNDYEAVKKAGAAGHKEVNRTNLSLVQIEEKMGLDVVKKQIEMLRFRNNFPAFGFDSDMDIQAVGSEIDITWKKEGYEARLKADLKTCEYEITGYGQNGFVYPL

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Crispr_ID: NC_014376_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014376_3

961319-961394

Orphan

Consensus_repeat	Method
AGGAACGCCTTACAGGCATCCCTTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014376_3

>merge|NC_014376|3|961319-961394|CRISPRCasFinder
AGGAACGCCTTACAGGCATCCCTTTCTGTCCAAAAAACATGGACAAGGAAGAGGAACGCCTTGCAGGCATCCCTTT

>NC_014376|3|2|961319-961394|CRISPRCasFinder
AGGAACGCCTTACAGGCATCCCTTT	CTGTCCAAAAAACATGGACAAGGAAG
AGGAACGCCTTGCAGGCATCCCTTT

Protein	Signature genes	Signature genes Name	Protein_function
NC_014376.1\|WP_013271607.1\|967119_967560_+\|Holliday-junction-resolvase-RuvX	unknown	unknown	gnl\|CDD\|234639
NC_014376.1\|WP_013271596.1\|955298_957161_+\|molecular-chaperone-DnaK	unknown	unknown	gnl\|CDD\|234715
NC_014376.1\|WP_013271594.1\|953518_954568_+\|heat-inducible-transcription-repressor-HrcA	unknown	unknown	gnl\|CDD\|234621
NC_014376.1\|WP_013271602.1\|962243_963398_+\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|224029
NC_014376.1\|WP_013271605.1\|965152_966517_+\|tRNA-(N(6)-L-threonylcarbamoyladenosine(37)-C(2))--methylthiotransferase-MtaB	unknown	unknown	gnl\|CDD\|223694
NC_014376.1\|WP_013271599.1\|959602_960349_+\|TSUP-family-transporter	unknown	unknown	gnl\|CDD\|182593
NC_014376.1\|WP_013271606.1\|966597_966858_+\|IreB-family-regulatory-phosphoprotein	unknown	unknown	gnl\|CDD\|180108
NC_014376.1\|WP_013271591.1\|950341_951565_+\|oxygen-independent-coproporphyrinogen-III-oxidase	unknown	unknown	gnl\|CDD\|180263
NC_014376.1\|WP_013271603.1\|963444_964623_+\|tRNA-4-thiouridine(8)-synthase-ThiI	unknown	unknown	gnl\|CDD\|234960
NC_014376.1\|WP_041708470.1\|967930_968404_+\|transcriptional-repressor	unknown	unknown	gnl\|CDD\|223806
NC_014376.1\|WP_013271601.1\|961429_962167_+\|16S-rRNA-(uracil(1498)-N(3))-methyltransferase	unknown	unknown	gnl\|CDD\|236959
NC_014376.1\|WP_013271592.1\|951674_952397_-\|phosphatase	unknown	unknown	gnl\|CDD\|270620
NC_014376.1\|WP_013271595.1\|954579_955230_+\|nucleotide-exchange-factor-GrpE	unknown	unknown	gnl\|CDD\|271355
NC_014376.1\|WP_013271600.1\|960358_961315_+\|50S-ribosomal-protein-L11-methyltransferase	unknown	unknown	gnl\|CDD\|234786
NC_014376.1\|WP_013271608.1\|967549_967831_+\|DUF1292-domain-containing-protein	unknown	unknown	gnl\|CDD\|377740
NC_014376.1\|WP_013271598.1\|958470_959025_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227588
NC_014376.1\|WP_013271593.1\|952682_953249_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|270620
NC_014376.1\|WP_013271597.1\|957294_958431_+\|molecular-chaperone-DnaJ	unknown	unknown	gnl\|CDD\|236757
NC_014376.1\|WP_013271604.1\|964766_965000_-\|PTS-sugar-transporter	unknown	unknown	gnl\|CDD\|224836
NC_014376.1\|WP_013271610.1\|968419_970087_+\|ribonuclease-J	unknown	unknown	gnl\|CDD\|223668

Protein	Function_ID	Function_description	E-value
NC_014376.1\|WP_013271607.1\|967119_967560_+\|Holliday-junction-resolvase-RuvX	gnl\|CDD\|234639	PRK00109, PRK00109, Holliday junction resolvase RuvX.	2.5366e-59
NC_014376.1\|WP_013271596.1\|955298_957161_+\|molecular-chaperone-DnaK	gnl\|CDD\|234715	PRK00290, dnaK, molecular chaperone DnaK; Provisional.	0
NC_014376.1\|WP_013271594.1\|953518_954568_+\|heat-inducible-transcription-repressor-HrcA	gnl\|CDD\|234621	PRK00082, hrcA, heat-inducible transcription repressor; Provisional.	5.56914e-102
NC_014376.1\|WP_013271602.1\|962243_963398_+\|cysteine-desulfurase	gnl\|CDD\|224029	COG1104, NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism].	1.72758e-171
NC_014376.1\|WP_013271605.1\|965152_966517_+\|tRNA-(N(6)-L-threonylcarbamoyladenosine(37)-C(2))--methylthiotransferase-MtaB	gnl\|CDD\|223694	COG0621, MiaB, 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis].	5.15198e-157
NC_014376.1\|WP_013271599.1\|959602_960349_+\|TSUP-family-transporter	gnl\|CDD\|182593	PRK10621, PRK10621, hypothetical protein; Provisional.	1.47235e-33
NC_014376.1\|WP_013271606.1\|966597_966858_+\|IreB-family-regulatory-phosphoprotein	gnl\|CDD\|180108	PRK05473, IreB-like, IreB family regulatory phosphoprotein. IreB (EF1202) was characterized in Enterococcus faecalis as a small protein, well-conserved in the Firmicutes. It belongs to a system that includes the Ser/Thr protein kinase IreK, and phosphatase IreP, undergoes phosphorylation on threonine residues, and is involved in regulating cephalosporin resistance. This family was previously named DUF965 by Pfam model pfam06135.	5.72016e-47
NC_014376.1\|WP_013271591.1\|950341_951565_+\|oxygen-independent-coproporphyrinogen-III-oxidase	gnl\|CDD\|180263	PRK05799, PRK05799, oxygen-independent coproporphyrinogen III oxidase.	1.42963e-152
NC_014376.1\|WP_013271603.1\|963444_964623_+\|tRNA-4-thiouridine(8)-synthase-ThiI	gnl\|CDD\|234960	PRK01565, PRK01565, thiamine biosynthesis protein ThiI; Provisional.	0
NC_014376.1\|WP_041708470.1\|967930_968404_+\|transcriptional-repressor	gnl\|CDD\|223806	COG0735, Fur, Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism].	1.06718e-47
NC_014376.1\|WP_013271601.1\|961429_962167_+\|16S-rRNA-(uracil(1498)-N(3))-methyltransferase	gnl\|CDD\|236959	PRK11713, PRK11713, 16S ribosomal RNA methyltransferase RsmE; Provisional.	1.09252e-79
NC_014376.1\|WP_013271592.1\|951674_952397_-\|phosphatase	gnl\|CDD\|270620	cd14667, 3D_containing_proteins, Non-mltA associated 3D domain containing proteins, named for 3 conserved aspartate residues. This family contains the 3D domain, named for its 3 conserved aspartates, including similar uncharacterized proteins. These proteins contain the critical active site aspartate of mltA-like lytic transglycosylases where the 3D domain forms a larger domain with the N-terminal region. This domain is also found in conjunction with numerous other domains such as the Escherichia coli MltA, a membrane-bound lytic transglycosylase comprised of 2 domains separated by a large groove, where the peptidoglycan strand binds. Domain A is made up of an N-terminal and a C-terminal portion, corresponding to the 3D domain and Domain B is inserted within the linear sequence of domain A. MltA is distinct from other bacterial LTs, which are similar to each other. Escherichia coli peptidoglycan lytic transglycosylase (LT) initiates cell wall recycling in response to damage, during bacterial fission, and cleaves peptidoglycan (PG) to create functional spaces in its wall. PG chains (also known as murein), the major components of the bacterial cell wall, are comprised of alternating beta-1-4-linked N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), and lytic transglycosylases cleave this beta-1-4 bond.	9.96184e-37
NC_014376.1\|WP_013271595.1\|954579_955230_+\|nucleotide-exchange-factor-GrpE	gnl\|CDD\|271355	cd00446, GrpE, nucleotide exchange factor GrpE. GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.	1.67299e-50
NC_014376.1\|WP_013271600.1\|960358_961315_+\|50S-ribosomal-protein-L11-methyltransferase	gnl\|CDD\|234786	PRK00517, prmA, 50S ribosomal protein L11 methyltransferase.	7.93948e-90
NC_014376.1\|WP_013271608.1\|967549_967831_+\|DUF1292-domain-containing-protein	gnl\|CDD\|377740	pfam06949, DUF1292, Protein of unknown function (DUF1292). This family consists of several hypothetical bacterial proteins of around 90 residues in length. The function of this family is unknown.	7.33743e-09
NC_014376.1\|WP_013271598.1\|958470_959025_+\|hypothetical-protein	gnl\|CDD\|227588	COG5263, COG5263, FOG: Glucan-binding domain (YG repeat) [General function prediction only].	1.92014e-13
NC_014376.1\|WP_013271593.1\|952682_953249_-\|hypothetical-protein	gnl\|CDD\|270620	cd14667, 3D_containing_proteins, Non-mltA associated 3D domain containing proteins, named for 3 conserved aspartate residues. This family contains the 3D domain, named for its 3 conserved aspartates, including similar uncharacterized proteins. These proteins contain the critical active site aspartate of mltA-like lytic transglycosylases where the 3D domain forms a larger domain with the N-terminal region. This domain is also found in conjunction with numerous other domains such as the Escherichia coli MltA, a membrane-bound lytic transglycosylase comprised of 2 domains separated by a large groove, where the peptidoglycan strand binds. Domain A is made up of an N-terminal and a C-terminal portion, corresponding to the 3D domain and Domain B is inserted within the linear sequence of domain A. MltA is distinct from other bacterial LTs, which are similar to each other. Escherichia coli peptidoglycan lytic transglycosylase (LT) initiates cell wall recycling in response to damage, during bacterial fission, and cleaves peptidoglycan (PG) to create functional spaces in its wall. PG chains (also known as murein), the major components of the bacterial cell wall, are comprised of alternating beta-1-4-linked N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), and lytic transglycosylases cleave this beta-1-4 bond.	5.08406e-30
NC_014376.1\|WP_013271597.1\|957294_958431_+\|molecular-chaperone-DnaJ	gnl\|CDD\|236757	PRK10767, PRK10767, chaperone protein DnaJ; Provisional.	3.50258e-175
NC_014376.1\|WP_013271604.1\|964766_965000_-\|PTS-sugar-transporter	gnl\|CDD\|224836	COG1925, FruB, Phosphotransferase system, HPr-related proteins [Carbohydrate transport and metabolism].	3.08902e-05
NC_014376.1\|WP_013271610.1\|968419_970087_+\|ribonuclease-J	gnl\|CDD\|223668	COG0595, COG0595, mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair].	0

>NC_014376.1|WP_013271600.1|960358_961315_+|50S-ribosomal-protein-L11-methyltransferase
MKWKKFTLTTTTEAVDLISSMFDEIGIEGIEIEDNTPLTEAETKGMFIDILPELPPDEGVAKVSFYLELDSDITGMLKRVEEGLSELSMFTDLGECTIESGETEDKDWINNWKQYFKPFTVDDILIKPTWEQIPEKDKDKLLIEIDPGTAFGTGQHETTQLCIRQLQKYVTPETTLLDVGTGSGILGITALKLGAKEVFGTDLDENAIAAVRENMKANHISGDKFQVLQGNIIDDKAVQEAAGFEKYDVVVANILADIILLLQKEISVHMKKDAFFITSGIINKKEEAVKKALEENTAFELVETTYQGEWVSITVRKK
>NC_014376.1|WP_013271599.1|959602_960349_+|TSUP-family-transporter
MHQYLIVCPLVFLAGFVDSIAGGGGLISLPAYLAAGIPPHFAIGTNKLGSTMGTVISTARYAKGGYIKAKLSLSAALLAVAGSVIGAHLSMLASERVLKGMMLAVLPVVAFYVLRNKNLGEREEDKGLPEKKMILISMCAALVIGCYDGFYGPGTGTFLLLILTGLAKMDVRSASGTTKVINLSSNIAALVTFLINGKVLIPLGLASGLFCIAGHYIGSGLVVKNGLKVVRPVVFVVLLCLFVKIIKG
>NC_014376.1|WP_013271598.1|958470_959025_+|hypothetical-protein
MGRFTKKLALGAAVILMASMFPVAVMAADGQTVRDFPGWNGSGTKIKGPVEGSESFDFWDDDDDGGPGSYSCPRGWRYSPSGWWFQYSDGSWPSNSWKYIDGRWYRFNWEGHMITGWFSDEGGLRYYLNPVDDGTLGAMRIGWQIIDGKAYCFNTKSDGYLGKLLTNTTTPDGYKVGADGAWIP
>NC_014376.1|WP_013271597.1|957294_958431_+|molecular-chaperone-DnaJ
MAESKKDYYETLGIPKDADDAAIKKAYRALAKKYHPDTNPGDAAAAEKFKQASEAYSVLSDPDKRRQYDQFGSAAFDGSGGAGGFGGFDFNGADMGDIFGDIFGDIFGGGRRSSARYNGPSRGANVRTSIRITFEDAIFGCEKEIEINFKEECSSCHGSGAKAGTSPVTCPKCNGKGKIMYTQQSFFGQIQNVQTCPDCEGSGKIVKDKCPDCYGNGYITRRKKFKVTIPAGIDNGQSVRLAGAGEPGTNGGERGDLLVEAVVSNHPIFKRQDTSIFSTVPISFANAALGGTIRIKTVDGEVDYEVKAGTQTDTKVRLKGKGVPSLRNRTIRGDHFVTLVVSVPERMNEAQKEALRKFEEAMNGTGEGEKHKKKGIFK
>NC_014376.1|WP_013271596.1|955298_957161_+|molecular-chaperone-DnaK
MGKIIGIDLGTTNSCVAVMEGGKPVVIPNSEGVRTTPSVVAFTKNGERLVGEPAKRQAVTNADRTISSIKRHMGTDYKVTIDGKNYSPQEISAMILQKLKADAEAYLGEKVTEAVITVPAYFNDAQRQATKDAGKIAGLDVKRIINEPTAAALAYGLDNEKEQKIMVYDLGGGTFDVSIIEIGDGVIEVLSTNGDTRLGGDDFDNRITQWMVDEFKKAEGVDLSGDKMAMQRLREAAEKAKKELSSSTTTNINLPFITATSEGPKHLDMNLTRAKFDELTADLIERTAIPVQNALRDAGITSAELGKVLLVGGSTRMLSAQEKVKQLTGKEPSKTLNPDECVAIGASIQGGKLAGDAGAGDILLLDVTPLSLSIETMGGVATRLIERNTTIPTKKSQIFSTAADNQTAVDIHVVQGERQFARDNKTLGQFRLDGIPPARRGVPQIEVTFDIDANGIVNVSAKDLGTGKEQHITITSGSNMSDSDIDKAVREAAEYEAQDKKRKEGIDARNDADSMVFQTEKALQEVGDKIDANDKATVEADLNALKEAIGRAPIDDMTDAQIEDIKAGKERLMNSAQALFAKVYEQAQSQAGAQGAGPDMGAGNAAYQDSDVVDGDYKEV
>NC_014376.1|WP_013271595.1|954579_955230_+|nucleotide-exchange-factor-GrpE
MSKEEVKTDEKLADEAVPTEDAASTEKEIEGAEACTDGGTQEHVTEEENTEAGSAEESGKKGFFGKKKEKKDPRDEKIEELTDRLQRTMAEFDNYRKRTEKEKTAMFEIGAKDIVERILPVVDNFERGLAAISDEEKSAPFADGMDKIYKQLMKTLEEAGVKPIEAVGKPFDPDFHNAVMHIEDESLGENIVSQELQKGYTYRDTVVRHSMVQVAN
>NC_014376.1|WP_013271594.1|953518_954568_+|heat-inducible-transcription-repressor-HrcA
MNDKDQLDERKITILKAIIKTYLETGEPVGSRTISKYTDLNLSSATIRNEMSDLEELGYIVQPHTSAGRIPSDRGYRFYVDQIMQEKEEEVTEIKDMMLKRVDRVELLLKQMAKLLAQNTNYAAMISAPQYHRNKLKFIQLSKVDEEKLLVVIVVEGNIIKNTMIPIHTELNDEGLLNLNILLNNALNGLTIEEINLEVISRLKIQAGTHCDVVDRVLTEVAAAIRGDDEDLQIYTSGATNIFKYPELSDGEKASKLIGTLEQKDLLQGLVDDVNSSESGSGIQVYIGDEAPVKTMKDCSIVTANYELGEGLRGTIGIIGPKRMDYEKVLSTLRNLMTQLDAILKKDER
>NC_014376.1|WP_013271593.1|952682_953249_-|hypothetical-protein
MNSFSGKKSITGFLTILCILLLSMTALAAETTDKDQAVNQAQSESSGTDHQTIQTGGDQAASSNTDTPKEEIGPGIRKKETEPEEPAKPVYEKGGSLGLFTATAYCPESSGKQCVTYSGTIPQPQHTISADIALLPLGTKVMIDDIVYTVEDIGSGVKGNKVDIFFASRREALDFGRQTKELFAVIER
>NC_014376.1|WP_013271592.1|951674_952397_-|phosphatase
MKRTSQIQRFLGTLLMMAFFLISTFSTSAAQTAGIIDNADESGVRGWAINTTDPAAAAEVKVVITNQANGQTVAELITNASQYREDLVSHGTGNYGFDIPVPWSSYGDGTYLVEAYGAGQKLSGTRIHPVGDLAAANLQNSSSSLRSLGVFRTTAYCPCRKCSGGWGGRTSTGTIAAANHTISVDPRVIPYGSRIMIGGVVYTAEDCGGGVKGNHIDIFFNTHGETRAYGSRNVEVYLVQ
>NC_014376.1|WP_013271591.1|950341_951565_+|oxygen-independent-coproporphyrinogen-III-oxidase
MMNKKNLEIYVHVPFCVRKCAYCDFLSFPGNRQMQREYTEKLIEEIQCQSAKVREYQVISVFIGGGTPSILNIEDMSAVFHALTNGFEILPDAEITMEVNPGTVTAESLSCYREAGVNRISMGLQSADDKELGYLGRIHTYDEFLKSYQRVRMAGFDNVNVDLISAIPGQTVESWKNTLKKVTMLKPEHISAYSLIVEEGTPYYDRYGEPVEVENHTVTQEKVHGLKSLPDLPDLPDEDAERDMYYLTRDFLKEQGYERYEISNYSKKGYECRHNIGYWTGTEYLGLGLGASSYLSGCRFHNTSVYKEYCSARLDREEVFQEVLRQEFERLTLEEKMEEYMFLGLRLTQGVSAQGFVSSFGHNIRSIYGPVLDAMEKDGLMEQNDGYYRLTSRGTDISNYVMSQFFV
>NC_014376.1|WP_013271601.1|961429_962167_+|16S-rRNA-(uracil(1498)-N(3))-methyltransferase
MHHFFVSQDQIEESFIRILGPDVNHIKNVLRMGAGEEILVSNGVDKDYLCQILDVASAEVTAKILSVEEGGTELPARLYLFQGLPKGDKMELIIQKAVELGVYQIIPVETKRAVVRLDQKKEESKLRRWRAVSESAAKQSGRLIIPEVAGVMTFPEALAFGKELDMIVIPFEHAKDMAKTKEILSSIRPGMSVGIFIGPEGGFEDSEMDLAERLGAKQITLGKRILRTETAGLAIVSVLAFQLED
>NC_014376.1|WP_013271602.1|962243_963398_+|cysteine-desulfurase
MEAYFDNSATTRVLEPVKDIVVKIMTEDYGNPSAKHKMGMEAERYIKEAAEIIAGTLKVAAKEIVFTSGGSESNNMALIEGAMANKRAGNHIISTAIEHASVYNPLAFLEEQGFSVTYLPVDSHGHIRLEDLEAAIRPETILVSIMYVNNEIGAVEPIEAISKVIKKKNPSILFHVDAIQAYGKFVIRPKRQGIDLLSVSSHKIHGPKGVGFLYIDQGVKIRPLIYGGGQQRGMRSGTENVPGIAGLGMAAKIMYTDHGEKVQSLTALKDNLITRLSEIDGVTVNSLPGDLSAPQIVSASFSGVRSEVLLHALEERNIFVSSGSACSSNHPAVSGTLKGIGVRPELLDSTLRFSFGFYNTKEEVDYCIDVLKELLPVLRRYQRG
>NC_014376.1|WP_013271603.1|963444_964623_+|tRNA-4-thiouridine(8)-synthase-ThiI
MQYQSFLIKYAEIGVKGKNRYLFEDALVTQIRHSLKWVEGDFVVSKESGRIYVNAESEYDFDEVIEAFKCIFGIAAICPMVQVEDHGYEDLKKQVLSYVEEFYEDQNFTFKVNTRRGNKKYPVNSEQINRDLGELILHTFPGTKVDVHKPDVMLHVEVRNKINIYSQSIPGPGGMPVGTNGKAMLLLSGGIDSPVAGYMIAKRGVKIDAVYFHAPPYTSERAKQKVIDLAKLVSRYSGPIHLHVVNFTDIQLYIYDKCPHEELTIIMRRYMMRIAERLAGECGAMALITGESIGQVASQTMQSLTATDAATTMPVFRPVIGFDKQEIVDVSEKIGTYETSVLPFEDCCTIFVAKHPVTKPNLKMIERSEENLEENIGELVETAIQTVEKIWC
>NC_014376.1|WP_013271604.1|964766_965000_-|PTS-sugar-transporter
MKTVRISLNSIDKVKSFVNDLTKFDTDFDLVSGRYVIDAKSIMGIFSLDLSKPIDLNIHSENNADEILNVLSPYIVD
>NC_014376.1|WP_013271605.1|965152_966517_+|tRNA-(N(6)-L-threonylcarbamoyladenosine(37)-C(2))--methylthiotransferase-MtaB
MKKAALHNLGCKVNSYETEAMQQLLENAGYEIVPFAEGADVYIINTCSVTNIADRKSRQMLHRAKKMNPGAVVVAAGCYVQAAGEELKKDEAVDLVIGNNKKTELVSVLEEYFASRKGPEAEIACGYPVLPPKAGLDAVIDIGDTREYENLSINRIADHTRAFIKVQDGCNQFCSYCIIPYTRGRVRSRKPDEVVEEVKRLTASGYQEIVFTGIHLSSYGMDFPEKERLTLLDLVKRVHEVEGLKRIRLGSLEPRIVTEKFAAELARLSKICPHFHLSLQSGCDDTLKRMNRHYTTEEYFNCCDVLRSAFHNPAITTDVIVGFPGERPEEFKTTREYLEKVQFYEMHVFKYSKRNGTKAAVMPDQIPESTKTDRSNELLCLEKEMSLAYRESWLGCRTEVLLEEEFWWNGTRYMIGHTREYVKAAVPYEEGLRGMVIEGKLMEMMNEEVAFLKR
>NC_014376.1|WP_013271606.1|966597_966858_+|IreB-family-regulatory-phosphoprotein
MGDIHNTQFFKAVQENKLNVSQVLEQVYIALTEKGYNPINQIVGYIMSGDPTYITSHKNARSLIMKVERDEILEELMGVYIDTMLK
>NC_014376.1|WP_013271607.1|967119_967560_+|Holliday-junction-resolvase-RuvX
MRIMGLDYGSKTVGVAVSDLLGITAQGVETITREEENKLRKTCARIEELIREYEIETIILGYPKNMNNSAGQRAEKTEQFKEMLIRRTGLNVILWDERLTTVASERILQESGVRREHRKAVIDQVAAGLILQGYLDSLPKETGNEQ
>NC_014376.1|WP_013271608.1|967549_967831_+|DUF1292-domain-containing-protein
MNSEEKKITLTTDNGETVDFYVLEETRINGRNYLLVTDAADEDDEGECYILKDLSKQEEALALYEFVEDDNEIDYLFKIFSELLDGADVDIEV
>NC_014376.1|WP_041708470.1|967930_968404_+|transcriptional-repressor
MLMKQEIFKNMLREKGLKVTNQRMLVLELMAERPGQHLTAEEIYDLARQTYPEIGLATIYRTVQVLVDLSVIDKVSFDDGFARYELGGVDRESRHHHHHAICNRCGNVFSFQGDLLDTLEQALLDRSGFLVTDHEVKLHGYCRECREAMEEEQDGKS
>NC_014376.1|WP_013271610.1|968419_970087_+|ribonuclease-J
MKKQDSNAKVKIIPLGGMEQIGMNITAFECEDSIIIVDCGLAFPTDDMLGIDLVIPDVSYLKQNIDKVKGFLITHGHEDHIGALPYILKDINVPVYGTKLTIALIENKLKEHNLLKNTKRKVIKHGQSVNLGCFRIEFIKTNHSIADASALAIFSPAGVILHTGDFKIDYTPVFGEPADLERFAELGKKGVLALMCDSTNATRAGFTPSERTVGKTFDNIFADHKNNRIIVATFASNVDRVQQVINSAAKYGRKVVVEGRSMVNVIGTASELGYINIPDGTLIDIDQLKNYPDEQTVLITTGSQGESMAALSRMASSTHKKISIKPSDVVILSSHPIPGNEKAVSKVINELSMKGAEVISDDTHVSGHACQEEIKLMYALVRPKYAIPVHGEYRHIMAQRNLVQAMGIPKENVIIMSSGDVVEVGQESWKTVDHVQAGGILVDGLGVGDVGNIVLRDRQNLAQNGIIVVVLTLEKYSNQLLAGPDIVSRGFVYVRESEDLMEEARNIVNDAVTDCLDRHVNDWGKIKNVIRDTLSDFLWKRMKRNPMILPIIMEV

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Crispr_ID: NC_014376_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014376_4

1666490-1666564

Orphan

Consensus_repeat	Method
GGGTATCCCTTTATGCCAAAAAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014376_4

>merge|NC_014376|4|1666490-1666564|CRISPRCasFinder
GGGTATCCCTTTATGCCAAAAAAACCTGGGCAGGAAAGAGGAAACACCCTGGGGGTATCCCTTTATGCCCAAAAA

>NC_014376|4|3|1666490-1666564|CRISPRCasFinder
GGGTATCCCTTTATGCCAAAAAA	ACCTGGGCAGGAAAGAGGAAACACCCTGG
GGGTATCCCTTTATGCCCAAAAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_014376.1\|WP_013272268.1\|1672325_1673219_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NC_014376.1\|WP_013272252.1\|1655566_1655992_+\|stage-V-sporulation-protein-AB	unknown	unknown	gnl\|CDD\|379365
NC_014376.1\|WP_013272261.1\|1665570_1666455_+\|4-hydroxy-tetrahydrodipicolinate-synthase	unknown	unknown	gnl\|CDD\|235107
NC_014376.1\|WP_013272256.1\|1658051_1660739_-\|penicillin-binding-protein	unknown	unknown	gnl\|CDD\|227342
NC_014376.1\|WP_013272265.1\|1668455_1669163_+\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	unknown	unknown	gnl\|CDD\|181800
NC_014376.1\|WP_013272269.1\|1673320_1674598_+\|adenylosuccinate-synthase	unknown	unknown	gnl\|CDD\|376374
NC_014376.1\|WP_041708566.1\|1666586_1667345_+\|4-hydroxy-tetrahydrodipicolinate-reductase	unknown	unknown	gnl\|CDD\|234595
NC_014376.1\|WP_013272258.1\|1661798_1663640_+\|translational-GTPase-TypA	unknown	unknown	gnl\|CDD\|224138
NC_014376.1\|WP_013272263.1\|1667421_1667739_+\|hypothetical-protein	unknown	unknown	unknown
NC_014376.1\|WP_013272260.1\|1664698_1665202_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376827
NC_014376.1\|WP_013272257.1\|1660901_1661555_+\|YigZ-family-protein	unknown	unknown	gnl\|CDD\|224653
NC_014376.1\|WP_013272271.1\|1675113_1676259_+\|cell-wall-binding-repeat-containing-protein	unknown	unknown	gnl\|CDD\|227588
NC_014376.1\|WP_013272254.1\|1656512_1657535_+\|stage-V-sporulation-protein-AD	unknown	unknown	gnl\|CDD\|236230
NC_014376.1\|WP_013272267.1\|1670817_1672248_+\|adenylosuccinate-lyase	unknown	unknown	gnl\|CDD\|176471
NC_014376.1\|WP_013272259.1\|1663843_1664470_+\|single-stranded-DNA-binding-protein	unknown	unknown	gnl\|CDD\|235616
NC_014376.1\|WP_013272270.1\|1674716_1674932_-\|hypothetical-protein	unknown	unknown	unknown
NC_014376.1\|WP_013272253.1\|1656027_1656480_+\|SpoVA/SpoVAEb-family-sporulation-membrane-protein	unknown	unknown	gnl\|CDD\|377146
NC_014376.1\|WP_013272264.1\|1667937_1668309_+\|hypothetical-protein	unknown	unknown	unknown
NC_014376.1\|WP_013272255.1\|1657617_1657974_+\|stage-V-sporulation-protein-AE	unknown	unknown	gnl\|CDD\|377146
NC_014376.1\|WP_013272266.1\|1669239_1670682_+\|amidophosphoribosyltransferase	unknown	unknown	gnl\|CDD\|235611

Protein	Function_ID	Function_description	E-value
NC_014376.1\|WP_013272268.1\|1672325_1673219_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	1.3929e-50
NC_014376.1\|WP_013272252.1\|1655566_1655992_+\|stage-V-sporulation-protein-AB	gnl\|CDD\|379365	pfam13782, SpoVAB, Stage V sporulation protein AB. This family of proteins is required for sporulation.	1.06465e-39
NC_014376.1\|WP_013272261.1\|1665570_1666455_+\|4-hydroxy-tetrahydrodipicolinate-synthase	gnl\|CDD\|235107	PRK03170, PRK03170, dihydrodipicolinate synthase; Provisional.	1.55084e-152
NC_014376.1\|WP_013272256.1\|1658051_1660739_-\|penicillin-binding-protein	gnl\|CDD\|227342	COG5009, MrcA, Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane].	3.1661e-128
NC_014376.1\|WP_013272265.1\|1668455_1669163_+\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	gnl\|CDD\|181800	PRK09362, PRK09362, phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed.	3.1132e-142
NC_014376.1\|WP_013272269.1\|1673320_1674598_+\|adenylosuccinate-synthase	gnl\|CDD\|376374	pfam00709, Adenylsucc_synt, Adenylosuccinate synthetase.	0
NC_014376.1\|WP_041708566.1\|1666586_1667345_+\|4-hydroxy-tetrahydrodipicolinate-reductase	gnl\|CDD\|234595	PRK00048, PRK00048, dihydrodipicolinate reductase; Provisional.	1.33837e-107
NC_014376.1\|WP_013272258.1\|1661798_1663640_+\|translational-GTPase-TypA	gnl\|CDD\|224138	COG1217, TypA, Predicted membrane GTPase involved in stress response [Signal transduction mechanisms].	0
NC_014376.1\|WP_013272267.1\|1670817_1672248_+\|adenylosuccinate-lyase	gnl\|CDD\|176471	cd03302, Adenylsuccinate_lyase_2, Adenylsuccinate lyase (ASL)_subgroup 2. This subgroup contains mainly eukaryotic proteins similar to ASL, a member of the Lyase class I family. Members of this family for the most part catalyze similar beta-elimination reactions in which a C-N or C-O bond is cleaved with the release of fumarate as one of the products. These proteins are active as tetramers. The four active sites of the homotetrameric enzyme are each formed by residues from three different subunits. ASL catalyzes two steps in the de novo purine biosynthesis: the conversion of 5-aminoimidazole-(N-succinylocarboxamide) ribotide (SAICAR) into 5-aminoimidazole-4-carboxamide ribotide (AICAR) and, the conversion of adenylsuccinate (SAMP) into adenosine monophosphate (AMP). ASL deficiency has been linked to several pathologies including psychomotor retardation with autistic features, epilepsy and muscle wasting.	0
NC_014376.1\|WP_013272260.1\|1664698_1665202_+\|hypothetical-protein	gnl\|CDD\|376827	pfam02572, CobA_CobO_BtuR, ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin adenosyltransferase, EC:2.5.1.17, involved in cobalamin (vitamin B12) biosynthesis. These enzymes catalyze the adenosylation reaction: ATP + cob(I)alamin + H2O <=> phosphate + diphosphate + adenosylcobalamin.	2.9113e-36
NC_014376.1\|WP_013272257.1\|1660901_1661555_+\|YigZ-family-protein	gnl\|CDD\|224653	COG1739, COG1739, Uncharacterized conserved protein [Function unknown].	4.64575e-59
NC_014376.1\|WP_013272271.1\|1675113_1676259_+\|cell-wall-binding-repeat-containing-protein	gnl\|CDD\|227588	COG5263, COG5263, FOG: Glucan-binding domain (YG repeat) [General function prediction only].	1.75861e-12
NC_014376.1\|WP_013272254.1\|1656512_1657535_+\|stage-V-sporulation-protein-AD	gnl\|CDD\|236230	PRK08304, PRK08304, stage V sporulation protein AD; Validated.	0
NC_014376.1\|WP_013272259.1\|1663843_1664470_+\|single-stranded-DNA-binding-protein	gnl\|CDD\|235616	PRK05813, PRK05813, single-stranded DNA-binding protein; Provisional.	3.68447e-136
NC_014376.1\|WP_013272253.1\|1656027_1656480_+\|SpoVA/SpoVAEb-family-sporulation-membrane-protein	gnl\|CDD\|377146	pfam03862, SpoVAC_SpoVAEB, SpoVAC/SpoVAEB sporulation membrane protein. Members of this family are all transcribed from the spoVA operon. Bacillus and Clostridium are two well studied endospore forming bacteria. Spore formation provides a resistance mechanism in response to extreme or unfavourable environmental conditions such as heat, radiation, and chemical agents or nutrient deprivation. The reverse process termed germination takes place where spores develop into growing cells in response to nutrient availability or stress reduction. Nutrient germinant receptors (GRs) and the SpoVA proteins are important players in the germination process. In B.subtilis the SpoVAC and SpoVAEB, belonging to this domain family, are predicted to be membrane proteins, with two to five membrane spanning. Biophysical and biochemical studies suggest that SpoVAC acts as a mechano-sensitive channel with properties that would allow the release of Ca-DPA (dipicolinic acid) and amino acids during germination of the spore. The release of Ca-DPA is a crucial event during spore germination. When expressed in E.coli SpoVAC provides protection against osmotic downshift. Furthermore, SpoVAC acts as channel that facilitates the efflux down the concentration gradient of osmolytes up to a mass of at least 600 Da. Another conserved SpoVA protein in all spore-forming bacteria is SpoVAEb, which appears to be an integral membrane protein with no known function.	2.79521e-44
NC_014376.1\|WP_013272255.1\|1657617_1657974_+\|stage-V-sporulation-protein-AE	gnl\|CDD\|377146	pfam03862, SpoVAC_SpoVAEB, SpoVAC/SpoVAEB sporulation membrane protein. Members of this family are all transcribed from the spoVA operon. Bacillus and Clostridium are two well studied endospore forming bacteria. Spore formation provides a resistance mechanism in response to extreme or unfavourable environmental conditions such as heat, radiation, and chemical agents or nutrient deprivation. The reverse process termed germination takes place where spores develop into growing cells in response to nutrient availability or stress reduction. Nutrient germinant receptors (GRs) and the SpoVA proteins are important players in the germination process. In B.subtilis the SpoVAC and SpoVAEB, belonging to this domain family, are predicted to be membrane proteins, with two to five membrane spanning. Biophysical and biochemical studies suggest that SpoVAC acts as a mechano-sensitive channel with properties that would allow the release of Ca-DPA (dipicolinic acid) and amino acids during germination of the spore. The release of Ca-DPA is a crucial event during spore germination. When expressed in E.coli SpoVAC provides protection against osmotic downshift. Furthermore, SpoVAC acts as channel that facilitates the efflux down the concentration gradient of osmolytes up to a mass of at least 600 Da. Another conserved SpoVA protein in all spore-forming bacteria is SpoVAEb, which appears to be an integral membrane protein with no known function.	1.11205e-42
NC_014376.1\|WP_013272266.1\|1669239_1670682_+\|amidophosphoribosyltransferase	gnl\|CDD\|235611	PRK05793, PRK05793, amidophosphoribosyltransferase; Provisional.	0

>NC_014376.1|WP_013272261.1|1665570_1666455_+|4-hydroxy-tetrahydrodipicolinate-synthase
MAIFEGAGVALVTPFKENGEVNYEKLEELTEEQIALGTDSIIVCGTTGEASTMTHEEHLEAIKFVCDVTRKRIPVIAGTGSNCTDTAVYLSKEAQRNGADGLLLVSPYYNKATQNGLKAHFKAVAGEVKIPILLYNIPARTGVNITAETIADLCLNVPNIVGVKEASGNFSAIADLMNLTDGRVDLYSGNDDQIVPMLSLGGKGVISVLSNIAPAQTHEICEAYFAGDVKRSAALQLAAIPLINALFCEVNPIPVKAALNLMGKGAGPMRLPLTEMEPKNQERLKQAMIAYGIL
>NC_014376.1|WP_013272260.1|1664698_1665202_+|hypothetical-protein
MSRGAIQVIYGEGKGKTAAAVGMGIAALAQNRTVIMIQFLKGCSGRTSFDVIKCLEPEMKIFRFEKSDCFFESLSKEQQEEERRNIRNGLNFAKKVVSTGECDMLILDEILGLLDQKIIEPEELTKLLQSKVDDMEVLLTGKVFQKEIEPYVDSILEIKHVKVDNTK
>NC_014376.1|WP_013272259.1|1663843_1664470_+|single-stranded-DNA-binding-protein
MSEKMIENNKVSVIGEIISGFTFSHEVFGEGFYMVDVAVNRLSEQADVIPLMISERLIDVEGDYTGLTVESIGQFRSYNRHEGTKNRLVLSVFVREIHFIEEFTDYTKTNQIFLDGYICKAPIYRKTPLGREIADLLLAVNRPYGKSDYIPCIAWGRNARYASGFSVGTRVKVWGRVQSREYTKKLSETECEKRVAYEVSVSKLECAE
>NC_014376.1|WP_013272258.1|1661798_1663640_+|translational-GTPase-TypA
MKMKREDVRNVAIIAHVDHGKTTLVDALLKQSGIFRENQEVMERVMDSNDIERERGITILSKNTAVHYSGTKINIIDTPGHADFGGEVERVLKMVNGVILVVDAYEGVMPQTKFVLRKALELGLSVVTCINKIDRPEARPQEVEEEVLELLMDLDANEEQLDCPFIYASAKAGFAKKELEDPEADMGPLFQTVIDHIPAPEGDPDASTQLLISTIDYNEYVGRIGVGKVDNGRIRVNQECVIVNHHDPDKFRKVKVGKLYEYEGLNKVEVQEATIGAIVAISGITDIHIGDTLCSSDKPEAIPFQKISEPTIAMNFMVNDSPLAGQEGKYITSRHIRERLFKELNTDVSLRVEETDSPDCFKVSGRGELHLSVLIENMRREGFEFAVSKAEVLYRYDERNHKLEPMEIAYVDVPEEFTGAVIQKLTSRKGELQGMSPANGGYTRLEFAIPSRGLIGYRGEFMTDTKGNGIMNTAFDGYAPFKGELSYRKTGSLIAYESGESITYGLFGAQERGSLFIGPGVKVYSGMVVGQNPKAEDIEINVCKTKKLTNTRSSSADESLKLTPPREMSLEQCLDFIDTDELLEITPSNLRIRKKILDPTLRKRSSLNKKSLA
>NC_014376.1|WP_013272257.1|1660901_1661555_+|YigZ-family-protein
MRKAYRILYQGGTGEITEKKSRFIANLKPVEREEEALAFIEETRKRYWDARHNCYAWIIGRGGEEKRLSDDGEPGQTAGKPMMDVLEGEKLVNLCAVVTRYFGGTLLGTGGLVRAYSKAVQEGLKACTPMTVEPAVKLSVLTDYNGIGKIQYLLGQREIATLGIEYTDRVELTALVPDEALDHLRADLTEATSGRAVLLVTGEVYYGIFNKDVILFP
>NC_014376.1|WP_013272256.1|1658051_1660739_-|penicillin-binding-protein
MNYGKQSTEKKIRSANSKARKYTTKVFLAFFKSLFVLCLFGGIVAASIGFGMAKGIIDNAPEVDIATIVPNEYATTVYDSAGNVTETLVTAGSNREEASYDELPKNLINAFVSYEDARFWDHNGIDLRSIMRAVKGVLTGDSSAGGGSTITQQLIKNSVFGGGMEKSFGERLERKLQEWFLAVKLDGAMSKEQIITNYLNTINLGNNSLGVKVAARRYFNKEVSDLTLSECAVLAGITQNPSKFNPITGQKANSDKQKVILQYMLDQGYITKEEEDKALADDVYSRIQNVDTATKETSSPYSYFTDELVEQVKKAMKDQLGYTDTQAHNLLYSGGLSIYTTQDPKLQTIVDEEINNPENYSAARYSIEYRLSVTHKDGTTTHYSQENIKHYHRENGDTGYDGLYNSEEAVQADIEGYKAYLLQDGDTILGESLHKTLQPQASFVLMDQKTGEVKAISGGRGQKTASLTLNRASNTYRQPGSTFKVLTAFAPAMDTCGATLGTVYYDSVYTVGNKTFSNWYSSGYQGYSSIREGIIYSMNIVAVRCLMETVTPQLGVEYAKNFGITSLTDTDYNPALALGGITTGVSNLELTGAFATIANGGVYKKPIFFTRILDHDGKVLIDNTPETHRVLKDSTAFLLTDAMADSMESSRKFSSSGPSSTSAAARIPGMSAAGKSGTTTANNDIWFVGYTPYYTAGIWAGCDDNQKLTKQNGGTSFHKGIWRKIMTRVHEGMSDPGFTVPDSIETAQICRKSGKLAVSGVCTNDPRGNAVYTEFFAKGTVPTDVCNNHVRATVCSVSHRLPTPYCPERTTAIFMAIPAGEEGATDDSKYAMPGYCTIHSANSIILPPGDGQNSSGGSPQQYEPGYPSQNPGYTPQNPGYTNPGGATQIPPWGGY
>NC_014376.1|WP_013272255.1|1657617_1657974_+|stage-V-sporulation-protein-AE
MDYLKAFIVGGVICALVQILMDNTKLMPGRIMVLLVVTGSILGALGIYQPFAEWAGAGATVPLLGFGNTLWKGVWKSMGEDGFLGIFKGGFTASAVGISGALIFGYLGSILFKPKMKS
>NC_014376.1|WP_013272254.1|1656512_1657535_+|stage-V-sporulation-protein-AD
MQIGKASIKFEEPPIIESMASIVGKKEGQGPLGKLFDVVEQDDMFGADTWEKAESALQKQTADLAIEKGDIRKKDIRYLFAGDLLGQLIATSFGTVDLEIPLFGLFGACSTMGEALNLGAMTVAGGYADKVMAMASSHFATAEKQFRFPLSYGNQRPYSASWTVTGCGAVVLAKHRKEGIAAVTGITTGRMVDMGIKDSMNMGAAMAPAAFHTIQQNFDDFQVDESYYDKIITGDLGQVGRTILLDFMKNKGHDLETVHMDCGIEMYNSEEQDTHAGGSGCGCAASTLCSYILPKIQNGTWKRVLFVPTGALLSTVSFNEGETIPGIAHAVVIENMGNLS
>NC_014376.1|WP_013272253.1|1656027_1656480_+|SpoVA/SpoVAEb-family-sporulation-membrane-protein
MEINKKAYEAYVKEVTPVHKKFPGIIKAFLVGGTICIFGQFVTTLFMNAGLEKEAASAWTTLVLIAASVILTGFNIYPKITKFGGAGALVPITGFANSVVAPAVEFKAEGQVFGIGCKIFTIAGPVILYGILSSWVLGIIAYVLKAFSML
>NC_014376.1|WP_013272252.1|1655566_1655992_+|stage-V-sporulation-protein-AB
MFLKEVFLVFIGLSAGGIIAAGVFAFLAIIGIFPRLIGITHTKKHILLYESFIILGGVLGNIWDIYEFPIGFGGNPVLGIYGLSAGIFVGILVMSLAETLKALPVMSRRIHLAVGLQYLILSLGLGKMMGSLLYFTGNLGK
>NC_014376.1|WP_041708566.1|1666586_1667345_+|4-hydroxy-tetrahydrodipicolinate-reductase
MIRMIMHGCNGAMGQVVTGIAAEEKNIVIVAGIDPHDTGQNPYPVFPSLESCNIEADVIVDFTSSKAVDGLLDYSVRKEIPVVVCTTGLSEEQMKKLEEAANHVAVLKSANMSLGVNLLMKLVKDAAQILAAAGFDIEILEKHHNKKLDAPSGTALALADSINEAMDQEFHYVYDRSQVRKARDKKEIGIQSVRGGTIVGEHDVIFAGTDEIVTFHHTAYSKAIFAKGAVSAAKFLAGKAPGFYTMKDVIDS
>NC_014376.1|WP_013272263.1|1667421_1667739_+|hypothetical-protein
MKRIKPFAIALIVIMTVMCLSACGTTKNNDGTSAGTTAATTQTTAATTKTDTTSAADTTGAGASTTGANESTGVVNGAVNDVEKGVDKITGESNGQPTTEVTKAP
>NC_014376.1|WP_013272264.1|1667937_1668309_+|hypothetical-protein
MKGKFDYFKYQRYNKKRKKTWRNLKRFIPHEESRILRLRKSLLLLLALEGTALTLLYGGMIGDNENGFLFFGYETKEEKEVTAEAFWARKTGETRERGLSVDWKDGTLKLWQKVERVILQGPD
>NC_014376.1|WP_013272265.1|1668455_1669163_+|phosphoribosylaminoimidazolesuccinocarboxamide-synthase
MEKKELLYEGKAKKVYTTEDPDVLIVSYKDDATAFNGLKKGTIVGKGAVNNRMTNFIFKKLEAKGVPTHLVEELNDRETVVKKVEIIPLEVIIRNYSAGSFAKKMGMEEGIKFACPTLEFSYKNDDLGDPFINSYYALALELATQDEIDKITEYAFKVNEVLKEYFDRLNIDLIDFKIEFGRYHNQVILADEISPDTCRLWDKDTHEKLDKDRFRRDLGGVEDAYEEVFRRLGIR
>NC_014376.1|WP_013272266.1|1669239_1670682_+|amidophosphoribosyltransferase
MNNEWDFNLEEELHEECGVFGMYDFDGCDVSSTIYYGLFALQHRGQESCGIAVSETEGPKGKVNAHKGMGLCNEVFTPEILENLRGNIGVGHVRYSTAGSSTRENAQPLVLNYLKGTLAMAHNGNLVNAPELRRELEYNGAIFQTTIDSEVIAYHIARERVKAATVEAAVANAMKKIQGAYSLVIMSPRKMIGVRDPYGFKPLCIGKRDNAYILVSESCALDTIGAEFVRDVRPGEIVTITKEGIVSDTSLCPEDKSKEARCIFEYIYFARPDSVFDGVSVYHSRVWAGRALALDSPVEADLVVGVPESGNAAALGYSLQSGIPYGTAFVKNSYVGRTFIKPKQSNRESSVRIKLNVLREAVMGRRVIMIDDSIVRGTTSALIVNMLREAGAKEVHVRISSPPFLHPCYFGTDIPNEEQLIAHNRTIEEIRKVLGADSLSYLKLERLNEMAEGLPICNACFSGNYPIEPPKEDIRGEHSE
>NC_014376.1|WP_013272267.1|1670817_1672248_+|adenylosuccinate-lyase
MTDRYQSPLSERYAGKEMQSIFSPDRKFKTWRRLWVALAEVEKELGLPISSEQIDELKAHQDDINYDVATQREKEVRHDVMSHVYAYGIQCPKAKGIIHLGATSCYVGDNTDIIIMTEALKLVRRKLLNVIDELARFAEKYKDLPTLAFTHFQPAQPTTVGKRAALWLHDLTMDLEDLDYILGSIRLLGSKGTTGTQASFLELFDGNMDKVRRADDMIAEKLGFSGCYPVSGQTYSRKVDSRVVNVLAGIAQSAHKFSNDIRLLQHLKEVEEPFEKSQIGSSAMAYKRNPMRSERMASLSNYVMADVMNPMLVSSTQWFERTLDDSANKRLSIPEGFLAVDGILDLYLNVVDGLVVYPKVIEKHMMAELPFMATENIMMDAVKAGGDRQELHERIRELSMEAGRNVKVNGLDNNLLELIAADSSFNLSLEDLKKSMDPKRYVGCAPAQVTAYLEEIVKPLLKENRDILGMKAEIHV
>NC_014376.1|WP_013272268.1|1672325_1673219_+|LysR-family-transcriptional-regulator
MSSNLEYYKVFYYVAQLESITLAAEKLCISQPAVSQAVRQLEKALDSQLFLRTSKGVRLTREGEFFYGYVKSGLESIWHGESMLKRLKDLETGEVRIGASDMTLQFYLLPYLEKFHELYPGIKVSVSNGPTPETLRYLYEGKIDFGVVSTPFEAKSEVMRIDVKEIKNVFVAGDNFRYLKDQELDYEILKELPCIFLEKNTSTRTFMDEYLSGRGITVEPEFELSTSDMIVQFAMRNLGIGCVMSGFAQMELEKENLVELKFRDEMPKRHFTIVTDSKTTVSPAGKRLLQLMTSDIS
>NC_014376.1|WP_013272269.1|1673320_1674598_+|adenylosuccinate-synthase
MVRAIVGANWGDEGKGKITDMLAKESDIIIRYQGGSNAGHTIINNYGKFALHLLPSGVFYHHTTSVIGNGVALNIPFLVKEIQDLVSKGVPKPEILVSDRAQILMPYHILFDQYEEERLGKKSFGSTKSGIAPFYSDKYAKIGFQVSELFNEESLKEKVERVCETKNVLMEHLYHKPAIDPEELFKTLLEYREMVKPYVCDVSKYLHEAIKAGKNILLEGQLGSLKDPDHGIYPMVTSSSTLAAYGAIGAGIPPYEIKNITTVVKAYSSAVGAGAFVSEIFGEEADELRRRGGDGGEYGATTGRPRRMGWFDAVASRYGCRIQGSTEVALTVLDVLGYLDELRICVGYEIDGKVTKDFPTTVELNRAKPVYTTLPGWKCEIRGIKNYGDLPENCRNYIEFIEKELETPITMVSNGPGRDEIIYRR
>NC_014376.1|WP_013272270.1|1674716_1674932_-|hypothetical-protein
MKWKRLLALAGLFIILAMYVIALISAFSHSPESKNWLMAAIISSAVIPVLLYAAQLVARVLKTSKSDSDRI
>NC_014376.1|WP_013272271.1|1675113_1676259_+|cell-wall-binding-repeat-containing-protein
MRKQWIAAACILLSIGSMMTSMAAEEKQPKVSGAQQPEVSGAQQPEVSGAQQPEVSGTQQAAVSDWQWLEEPDGWKYVNAAGEFKKNCWEEIDGYWYYFQYNGFMASDWTRIGGMNYCFSESGEQMLGWCYNDEEEKWHYYKEDGTAQKGWYQDDRKNWYWFSIKGEMAASGYKNISGKRYYFFDNGQLAANQFVGLFYMDENGQRNKEFDITLDGKKTSSSVSSEAKDAFTEASKNIPRDWIKKFTDQGWEIIYYPGKQYLSAPMTESGIYYVCHKLDINYKKIKICQPEDLTAAFGEYIGYVSGLYSSSSQDATDLLMGRDSVEEFVYIPDYFSDDMKFYFGKLVAAYVGNSSDRAEMEESAPQVTEILKRILYHDKRE

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Crispr_ID: NC_014376_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014376_5

2198107-2198180

Orphan

Consensus_repeat	Method
TTTTTGGACATAAAGGGATGCCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014376_5

>merge|NC_014376|5|2198107-2198180|CRISPRCasFinder
TTTTTGGACATAAAGGGATGCCCCAGGGTGTTTCCTTAATCTTGTCCATGTTTTTGGACATAAAGGGATGCCCC

>NC_014376|5|4|2198107-2198180|CRISPRCasFinder
TTTTTGGACATAAAGGGATGCCCC	AGGGTGTTTCCTTAATCTTGTCCATG
TTTTTGGACATAAAGGGATGCCCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_014376.1\|WP_013272701.1\|2188160_2189600_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378926
NC_014376.1\|WP_013272712.1\|2199112_2199808_-\|JAB-domain-containing-protein	unknown	unknown	gnl\|CDD\|178801
NC_014376.1\|WP_013272715.1\|2200327_2201608_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|311036
NC_014376.1\|WP_041708606.1\|2194701_2197566_-\|penicillin-binding-protein	unknown	unknown	gnl\|CDD\|274573
NC_014376.1\|WP_013272707.1\|2193104_2193896_-\|septum-site-determining-protein-MinD	unknown	unknown	gnl\|CDD\|225447
NC_014376.1\|WP_013272719.1\|2207479_2208928_-\|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB	unknown	unknown	gnl\|CDD\|237675
NC_014376.1\|WP_013272714.1\|2199910_2200162_-\|DUF4321-domain-containing-protein	unknown	unknown	gnl\|CDD\|379506
NC_014376.1\|WP_013272711.1\|2198194_2199112_-\|rod-shape-determining-protein-MreC	unknown	unknown	gnl\|CDD\|237560
NC_014376.1\|WP_013272702.1\|2189782_2190202_-\|hypothetical-protein	unknown	unknown	unknown
NC_014376.1\|WP_013272708.1\|2194015_2194681_-\|septum-site-determining-protein-MinC	unknown	unknown	gnl\|CDD\|179052
NC_014376.1\|WP_013272718.1\|2204651_2207306_-\|DNA-mismatch-repair-protein-MutS	unknown	unknown	gnl\|CDD\|235444
NC_014376.1\|WP_013272705.1\|2191687_2192812_-\|rod-shape-determining-protein-RodA	unknown	unknown	gnl\|CDD\|274033
NC_014376.1\|WP_013272706.1\|2192814_2193093_-\|cell-division-topological-specificity-factor-MinE	unknown	unknown	gnl\|CDD\|237579
NC_014376.1\|WP_013272720.1\|2209043_2209856_-\|DUF1189-domain-containing-protein	unknown	unknown	gnl\|CDD\|377690
NC_014376.1\|WP_013272704.1\|2191274_2191670_-\|methylglyoxal-synthase	unknown	unknown	gnl\|CDD\|179969
NC_014376.1\|WP_013272716.1\|2201604_2202561_-\|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	unknown	unknown	gnl\|CDD\|234626
NC_014376.1\|WP_041709096.1\|2197558_2198077_-\|rod-shape-determining-protein-MreD	unknown	unknown	gnl\|CDD\|274574
NC_014376.1\|WP_013272717.1\|2202560_2204480_-\|DNA-mismatch-repair-endonuclease-MutL	unknown	unknown	gnl\|CDD\|234630
NC_014376.1\|WP_013272722.1\|2210172_2211603_-\|glycoside-hydrolase-family-1-protein	unknown	unknown	gnl\|CDD\|181973
NC_014376.1\|WP_013272703.1\|2190291_2191260_-\|D-alanyl-D-alanine-carboxypeptidase	unknown	unknown	gnl\|CDD\|224600

Protein	Function_ID	Function_description	E-value
NC_014376.1\|WP_013272701.1\|2188160_2189600_-\|hypothetical-protein	gnl\|CDD\|378926	pfam12700, HlyD_2, HlyD family secretion protein. This family is related to pfam00529.	2.39057e-18
NC_014376.1\|WP_013272712.1\|2199112_2199808_-\|JAB-domain-containing-protein	gnl\|CDD\|178801	PRK00024, PRK00024, DNA repair protein RadC.	7.54983e-91
NC_014376.1\|WP_013272715.1\|2200327_2201608_-\|hypothetical-protein	gnl\|CDD\|311036	pfam06838, Met_gamma_lyase, Methionine gamma-lyase. This is a putative pyridoxal 5'-phosphate-dependent methionine gamma-lyase enzyme involved in methionine catabolism.	0
NC_014376.1\|WP_041708606.1\|2194701_2197566_-\|penicillin-binding-protein	gnl\|CDD\|274573	TIGR03423, pbp2_mrdA, penicillin-binding protein 2. Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	2.75731e-77
NC_014376.1\|WP_013272707.1\|2193104_2193896_-\|septum-site-determining-protein-MinD	gnl\|CDD\|225447	COG2894, MinD, Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning].	1.77612e-143
NC_014376.1\|WP_013272719.1\|2207479_2208928_-\|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB	gnl\|CDD\|237675	PRK14328, PRK14328, (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional.	0
NC_014376.1\|WP_013272720.1\|2209043_2209856_-\|DUF1189-domain-containing-protein	gnl\|CDD\|377690	pfam06691, DUF1189, Protein of unknown function (DUF1189). This family consists of several hypothetical bacterial proteins of around 260 residues in length. The function of this family is unknown.	3.30084e-50
NC_014376.1\|WP_013272711.1\|2198194_2199112_-\|rod-shape-determining-protein-MreC	gnl\|CDD\|237560	PRK13922, PRK13922, rod shape-determining protein MreC; Provisional.	5.58695e-64
NC_014376.1\|WP_013272704.1\|2191274_2191670_-\|methylglyoxal-synthase	gnl\|CDD\|179969	PRK05234, mgsA, methylglyoxal synthase; Validated.	1.65463e-63
NC_014376.1\|WP_013272708.1\|2194015_2194681_-\|septum-site-determining-protein-MinC	gnl\|CDD\|179052	PRK00513, minC, septum formation inhibitor; Reviewed.	1.58031e-34
NC_014376.1\|WP_013272718.1\|2204651_2207306_-\|DNA-mismatch-repair-protein-MutS	gnl\|CDD\|235444	PRK05399, PRK05399, DNA mismatch repair protein MutS; Provisional.	0
NC_014376.1\|WP_013272705.1\|2191687_2192812_-\|rod-shape-determining-protein-RodA	gnl\|CDD\|274033	TIGR02210, Rod_shape-determining_protein_RodA, rod shape-determining protein RodA. This protein is a member of the FtsW/RodA/SpoVE family (pfam01098). It is found only in species with rod (or spiral) shapes. In many species, mutation of rodA has been shown to correlate with loss of the normal rod shape. Note that RodA homologs are found, scoring below the cutoffs for this model, in a number of both rod-shaped and coccoid bacteria, including four proteins in Bacillus anthracis, for example. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Cell division].	4.56377e-87
NC_014376.1\|WP_013272706.1\|2192814_2193093_-\|cell-division-topological-specificity-factor-MinE	gnl\|CDD\|237579	PRK13987, PRK13987, cell division topological specificity factor MinE; Provisional.	3.87657e-23
NC_014376.1\|WP_013272714.1\|2199910_2200162_-\|DUF4321-domain-containing-protein	gnl\|CDD\|379506	pfam14209, DUF4321, Domain of unknown function (DUF4321). This family of proteins is functionally uncharacterized. It is found in bacteria, and is approximately 50 amino acids in length.	8.35141e-11
NC_014376.1\|WP_013272716.1\|2201604_2202561_-\|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	gnl\|CDD\|234626	PRK00091, miaA, tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed.	4.14151e-152
NC_014376.1\|WP_041709096.1\|2197558_2198077_-\|rod-shape-determining-protein-MreD	gnl\|CDD\|274574	TIGR03426, shape_MreD, rod shape-determining protein MreD. Members of this protein family are the MreD protein of bacterial cell shape determination. Most rod-shaped bacteria depend on MreB and RodA to achieve either a rod shape or some other non-spherical morphology such as coil or stalk formation. MreD is encoded in an operon with MreB, and often with RodA and PBP-2 as well. It is highly hydrophobic (therefore somewhat low-complexity) and highly divergent, and therefore sometimes tricky to discover by homology, but this model finds most examples. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	7.83607e-07
NC_014376.1\|WP_013272717.1\|2202560_2204480_-\|DNA-mismatch-repair-endonuclease-MutL	gnl\|CDD\|234630	PRK00095, mutL, DNA mismatch repair endonuclease MutL.	0
NC_014376.1\|WP_013272722.1\|2210172_2211603_-\|glycoside-hydrolase-family-1-protein	gnl\|CDD\|181973	PRK09589, celA, 6-phospho-beta-glucosidase; Reviewed.	0
NC_014376.1\|WP_013272703.1\|2190291_2191260_-\|D-alanyl-D-alanine-carboxypeptidase	gnl\|CDD\|224600	COG1686, DacC, D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane].	6.55509e-66

>NC_014376.1|WP_041709096.1|2197558_2198077_-|rod-shape-determining-protein-MreD
MRRILFNVLMIILAFTIQNCIFPLLPFLSASPNLLLILTFSFGFMHGKEAGMYYGLLAGLLMDLFYSGPFGFYTLIFIYVGYINGICTKYYYEDYITLPLILSVLNELAYNLYIYVFRFLIRQKLRVGYYFINLMLPEIIFTVVTTLLLYRVFLILNRHLEEIGKRGDSAIV
>NC_014376.1|WP_041708606.1|2194701_2197566_-|penicillin-binding-protein
MFSDLLDIIKDYFKKAVSSRLFILGTICFFMYAGLINKLFSMQIVNGEEALNEYLQLTEQTITTAGTRGNVYDRNGKVLAYNKLAYSVTVQDTGVYKNSSARNSMYLRLVQILERHGETIQGKFEVAIDSNGDMVYTSSSESSRKRFLRDYYGLKKVEDLDDAKGSFPSNLSARELFDRACKDNGLSDMKDPDGNAINLTDQEALDIINIKYALRLMSYRKYEATTVASQVSDETVADILEHIGEMQGVNVEETTIRAYNDSIPFAPVIGYTGKVPEDQLEGLQKKKDDYDINDIVGRTGIEYTMEHELQGTKGKKTIYKDSVGRIRETKDETDASAGNDVYLTLDADLQKGIYHLIEQSLAGVLIKTIVNGDYRAGTTTDGSNMKIPVKDAYYQLINNNVLSLKEMEEEDASETEKNIYRKYMSSQQQIFNNLNNELMSTHATAMKDLSEDMKAYMFYIYTYLSGPTVGIIKEDAIDTSSGEYQAWKTDEISLRDYLYYGIANGWVDTTKLETGAKYSSADDTFKALIGYVLDNLKEDRNFTKKIYRYLINDEVITGQELCLALYDQGVLQDNGQDAAELRATGDAYAFLIKKLSTLEITPAQLALTPCNAGVVVTNDKTGEVLALVSYPGYDNNRIGDGSYFSQLQADLSLPLYNNATQTRKAPGSTFKPITAVAALEEHAVTTDETINCTGIYTDVEPPIKCWIYSGQHGPLNIVGGIENSCNFFFADLGHRLSTDASGVYSPDLGLDVLRKYAAMFGLDHKSGVEIAELDPQISKEAPERSAMGQGSHAYTNVQLSRYVSAIANRGTVFELSLLDKTTDSEGNLIQDYTPKISSHIDAAASTWDTVQQGMREVITNGSSKRLFSDLEVEIAGKTGTAQEARNKPNHAFFISYAPYDNPEICVTVNIPYGYSSSNAANIAKNVYKYYYGYTDLESIINAGALDAAKVNIRD
>NC_014376.1|WP_013272708.1|2194015_2194681_-|septum-site-determining-protein-MinC
MHNTVVIKSNRAGMTVILDPDIPFPQLLSDIGKKFGDHAKFWGSVQMTLTLEGRELTSEEEFEIINQITENSNVEIICLVDTDVNRMERCEKALNEKLMELSCQTGQFFKGNLQSGETLESEASIVIIGDVCRGAKVLAKGNVIVLGKLSGTVCAGVAGNRGALITALDMAPIQLRIADCTSGLDGRGKRLGRGPMKAFMENNKVIIKPMKKSVEIFQKLR
>NC_014376.1|WP_013272707.1|2193104_2193896_-|septum-site-determining-protein-MinD
MSEIIVITSGKGGVGKTTTSANVGTGLAILGKKVVLIDTDIGLRNLDVVMGLENRIVYNLVDVVEGNCRMKQALIKDKRYPNLFLLPSAQTRDKTAVTPGQMVKLVEDLREDFDYILLDCPAGIEQGFQNAIAGADRAIVVTTPEVSAIRDADRIIGLLEAADMGTIELIVNRIRADMVKRGDMMSLDDVMDILAVDIIGAVPDDEDIVISSNQGEPLVGMGTPAGQAYMDICRRITGENVPLHNPAVREGLFFKLSHLLKRA
>NC_014376.1|WP_013272706.1|2192814_2193093_-|cell-division-topological-specificity-factor-MinE
MSLFPVFGKKNSGEIARNRLKLLLVADKADCSPEIMQMIKDDMVRVVSRYMDIDSDRIEIQMKKLKQPDCERFIPVLYANIPIRDVPDKGIY
>NC_014376.1|WP_013272705.1|2191687_2192812_-|rod-shape-determining-protein-RodA
MFFDYNFKYFNYRLVLYMLSLSVIGILVVASASNQDSGTVTKQMIGVMVGFALAIGLSIIDYHKLIKLYALDYAACIILLGAVLVMGHTAGGATRWINLPGIGRIQPSEFVKIGLIVFFSWYWNKYQERMNTPIMIGLAALLAAIPIGLILAEPNLSTSLVVIIIILCMVFSAGISYRWIGGVLAVAIPAGALFIFLLTKGMIPFIHDYQARRILAWIYPHAEQYAENLYQQKNSIMAISSGQLQGKGLFNTTIASVKDGNFLSAGETDFIFAIIGEEMGFRGSVIVIVLIGLVVFECLYLASKSKDMSGKLICTGMAALIGFQAFANIAVATQIFPNTGLPLPFISSGVSSLISIFMGMGLVLNVGLQRKIGN
>NC_014376.1|WP_013272704.1|2191274_2191670_-|methylglyoxal-synthase
MNIGLVAHDSKKKLMQNFCIAYRGILSKHMLYATGTTGRLIEEVTNLNVHKYLAGHLGGEQQLGSQIEHNEIDLVIFLRDPLTPKSHEPDIVNIMSTCDMHNIPLATNLATAELLIKSLDRGDLEWREMYK
>NC_014376.1|WP_013272703.1|2190291_2191260_-|D-alanyl-D-alanine-carboxypeptidase
MKKRVFIKSGCIALCAVFLTGCAGFKGLDNPYVFSERTALYQSSAVSGKSEPFAHDLCIVSEDTSSKDGAVTAEAAAVFDLTDKKVLFAKNPFERLYPASITKTMTALIALKYGNLTDEVTVTGDAVITEAGASLCGIKPGDKLTMEQLLYGLMLPSGNDAGAAIATHIAGGIDQFSQMMNEEAGKIGATGTHFLNPHGLNDENHYTTAYDLYLIFNEALKYPEFRKIIATTEYTTTYQDGAGSPVNATWKGTNWYMTGERQMPEGLTVLGGKTGTTKAAGSCLIMGSSDSSQREYVTVVLKAPNHAGLYDNMTNILNKIVE
>NC_014376.1|WP_013272702.1|2189782_2190202_-|hypothetical-protein
MVQIIAGKKGKGKTKHLLDRANSIVKESTGSIAYLDKSSKHMYELSNKIRLINVNEYPITSSEGFIGFICGIISQDHDLEMMFFDSFLKLACLEGEDISETIATLEKIGEKYHVTFVLSVSLDAENMPENAKANVVVSL
>NC_014376.1|WP_013272701.1|2188160_2189600_-|hypothetical-protein
MAKQKAPQPLKRAARPKKNKKIIRYRRPLNINVGMIIFALIFVYMVFSVTAYFRRDKVQFYEVQEGGIVNNKNYTGIILRQEEVKNADRSGYVNYYVREGKRASNGTRVYSIDETGNLTSFLAENSEEKVTLTPENLAELKKQLTAFSLTYDTDQFRSVYDTKYALEAEVMEYMNFNALDNLGDQMDKAGINFEQVKADKAGIVSYGVDSYEGLQPATVSETVFDRSKYVKTITKSGKLIEKGAPVYKVITSDLWSVVFPMTEEDSKSYGDKTSLTVEFSGRNLRAAGSFSVFTGTDGKPFGKLDFDKYMVQFASDRYVDFEIVSDRVDGLKIPVTAVTKKDFFLVPMDYVTQGGDSQSTGFNKEIYSQSGTSVVFVPTEIYYSEGDNYYIEMGEEDGFKAGDYIVKPNSTERYQIGTSASLQGVYNINKGYAVFKQIDVLASNDEYYTVKKNMTYGLAVYDHIVLNAESVSEGELIYK
>NC_014376.1|WP_013272711.1|2198194_2199112_-|rod-shape-determining-protein-MreC
MESKRSKYVLIALTVFCVLLIGLTSIHDEWLTPLRTGVGYFLIPVQSGVNAAGSAIYDEIMDYTKLHDALNENKEMKEIITQLTEENTRLQAEEFELIRLRQLYSLDQEYGQYPKVGARVIANDSSNWFQVFRIDKGSKDGIAPDMNVVAGGGLVGIVTDVGANYATVRSIIDDSSRVSGMAMQSGNSCIVAGDLTLFKEGRLRITNVLKESDLKDGDKIVTSNISSVFLPGILIGYASEITNDTNNVTKSGYLIPAAKFDSLQEVLVITELKSDMMKEEDSSKGETSVPETASSEADTAESASR
>NC_014376.1|WP_013272712.1|2199112_2199808_-|JAB-domain-containing-protein
MKRITMKDIPTDERPYEKCLKEGPEGLSDAELLSIIIRTGSKEYNSLALAQKILALNYPKEGILGLLHLSMPELMSVKGIGAVKGAQLLCVGELSRRIWKRTALSQGTNFCRPLDIVNYFVEDMRHKEQELVYIALLNTKGSLIRDIMISQGTVNASAVSPREIFIEAMKYHAVSLVLVHNHPSGDPSPSREDLSFTRRVKEAGDLVGIRLLDHIIIGDNSYISLKERGIL
>NC_014376.1|WP_013272714.1|2199910_2200162_-|DUF4321-domain-containing-protein
MKYKNCWVLLLLMLAGVVLGGFVGDLAGGISWLSWLNAGQSFGFDTPLVINFGILVITFGINIKITMAGIIGVAAALITYRLI
>NC_014376.1|WP_013272715.1|2200327_2201608_-|hypothetical-protein
MNINAMYESLGISSQVMALGKEMEESLTERFKEIDETAEYNQMKVIKAMQDNRVSDIHFAATTGYGYNDLGRDTLEAVYASVFHTESALVRPNLISGTHALTVALSGNLRPGDELLSPVGKPYDTLEEVIGIRDSTGSLKEYGVVYRQVDLLKDGTFDYESIKKAVNEKTKLVTIQRSKGYDTRPTFSVSQIGELISFIKKLKPDVVCMVDNCYGEFVERLEPSDVGADMVVGSLIKNPGGGIAPIGGYIAGRSDLIDRASYRLTAPGLGKEVGATLGLNQPFFQGLFLSPTVVAGALKGAVFAANVYEKLGFSVVPDGSQSRHDIIQAVTFGKPEGVIAFCQGIQAAAPVDSFVTPEPWDMPGYDAPVIMAAGAFVQGSSIELSADGPIKPPYAVYFQGGLTWYHAKLGILMSVQKLLEAGLIRL
>NC_014376.1|WP_013272716.1|2201604_2202561_-|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA
MKPLIIITGPTAVGKTALSIRLAKAIGGEIISADSMQVYRHMDIGSAKITREEMEGVPHYLIDVLNPEEEFNVTVFQKMAMEAMEKIDSHGHIPIVTGGTGFYIQALLYDIDFTENGEDSSIRRELEKLGQERGAGVLHGLLKDIDPDSAAEIHENNIKRVIRAIEYYRQTGERISVHNKRERLKKSPYDFLYYVVNTDRARLYERIDQRVDLMLEQGLVEEVMHLKDLGLTRDMVSMQGLGYKEILDYLQGIHTLEEAVYVLKRDTRHFAKRQITWFKREQDVRWLNLPDFNNDLDQVLERILQDTYEMYGLENNKQ
>NC_014376.1|WP_013272717.1|2202560_2204480_-|DNA-mismatch-repair-endonuclease-MutL
MPNITVLDQNTINKIAAGEVIERPASVVKELLENAIDARATAVTVEIKEGGTSLIRVTDNGCGIPKEEVSLAFLRHSTSKIKSVEDLFTVSSLGFRGEALASIAAVSQVELITKTSIGLTGTRYQIDGGQERSMEEVGAPEGTTFIARNLFYNTPARKKFLKTPMTEGAHVAELVEKLALSHPEVSIRFIQNNQNKLHTSGNHNLKDIVYTVFGREIAANLLEVTVKKPEVSIHGYIGKPVISRGNRNYENYFINGRYIKSSIISRAIEEAYKPFMMQHKYPFTMLHFSIDPEMLDVNVHPTKMELRFRDGEMIYHMVYQAVSSALAHKELIPEVKLEKKAEEKKGFLEKKHEPSPEPFEKRRLMAIEQQAAALENKELSIPFPKRLTPPPASLLMERDELGDNWLKPKAPDIDSQQEVPPVPAVSKQEEKTEQLDLFDGKLLEPKARSMHKLIGQVFDTYWLVEFHEQLYIIDQHAAHEKVLYEKTMGTLKSKEYLSQLVSPPIILTLNQNEEALLKRHLKYFTDIGFEIEPFGGREYAVRGVPANLFSIAKKELLIEMIDGLSEDGSSHSPDIIYEKVASLSCKAAVKGGHRLSAAEANELIDQLLNLENPYACPHGRPTIISMSKYELEKKFKRIL
>NC_014376.1|WP_013272718.1|2204651_2207306_-|DNA-mismatch-repair-protein-MutS
MAGLSPMMTHYMETKKEYPDCILFYRLGDFYEMFFDDAVTVSKELEITLTGKECGLEERAPMCGVPYHAVDTYLNRLVQKGYKVAIAEQMEDPRLAKGLVKREVIRVVTPGTITSAQALDESKNNYLMGIVYIGETFGIAVADISTGDFLVTEVESERELTDEINKFTPSEIICNEAFYVSGVDIEEIKNRHHAVISSLDHHFFSDEVCRKILKEHFKVGALAGLGLEDYDNGVIAAGAVMEYMYETQKSSLSHITTITPYSTGQYMIIDTSTRRNLELLETLREKQKRGSLLWVLDRTKTAMGARMLRTYIEQPLIHKPEITKRQNAIEELNMSFISREEICEYLNPIYDLERLIGRISYKTANPRDLIAFKSSLEMLPHIKNLLKEFSSDMLKDLWGELDPLEDVRELIGRAIIDDPPVTLRDGGIIRDGFHEEADKLRSAKTEGKNWLADLESQEKEKTGIKNLKVKFNKVFGYYFEVTNSFKDLVPDYFIRKQTLANAERYTTDQLKELENVILGAEDKLFSLEYSLFCQVRDSVADQVLRIQKTARAIAGIDVLTSLSSVATRNNYVKPQINEKGLIDIKNGRHPVVEKMMRDDLFVSNDTYLDNGKNRVSIITGPNMAGKSTYMRQTALIVLLAQIGSFVPAEEANIGICDRIFTRVGASDDLASGQSTFMVEMTEVANILRNATKNSLIVLDEIGRGTSTFDGLSIAWAVVEHISNPKILGAKTLFATHYHELTELEGTMSGVNNYCIAVKEQGDDIVFLRKIIKGGADKSYGVQVAKLAGVPDSVIVRAKELLAELSDADITAKAREIAGINANIIQRKVVPKPDEVDLQQMSLFDTVKDDDIIKELGELELGNMTPIDALNILYRLQTKLKNRWQ
>NC_014376.1|WP_013272719.1|2207479_2208928_-|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB
MNDINMTYEEALSHAPQEEPARQYFFIERCQDILENLKEVSGKEQLTFHIATFGCQMNSRDSEKLQGILEAIGFVEHDTEEADFVLYNTCTVRENANDRVYGRLGYLNSLKKKNPYMMIALCGCMMQEEEVVAKIKKSYRFVDIIFGTHNIFKLAELMYERLEEKKMVVDIWEGTDRIVEDLPTERKYSFKSGVNIMFGCNNFCSYCIVPYVRGRERSRSPKDILEEIKQLVNDGVVEIMLLGQNVNSYGKTLDTPVSFAELLTQIDQVEGLERIRFMTSHPKDLSDELIKAMKNSKKVCHHLHLPLQSGSSRILKVMNRKYTKEQYLELVEKIRTAIPDISLTTDIIVGFPGETEEDFNETLEVVRKVRFDSAFTFIYSKRTGTPAAKMEEQVSEEAIKNRFDRLLDEVKNISSEVCGREVHTVQKVLAEEVNDHEEGLLTGRLGNNTTVHFKGDSSLIGKIVDVYLDESRGFYYMGTLRP
>NC_014376.1|WP_013272720.1|2209043_2209856_-|DUF1189-domain-containing-protein
MNVFKELILSVYDFKSYKEFLKNKRRKVFLAGIILTVIYFALTMIVPFIKFQVKTGGFVKIINDYIPDFELSDGEFWIEKPIEYEADGTYININTNPDHIFYDADEIGEYLSDYYQVFLIDSEKVIVKNKGQIQGQYFSDLNIDFSRDKLMAFVPQAYLIVAGIMVAAFLFMAAFFFFGVLIVALLGMIAASCMKYKLTFGQLYQMGVYARTLPLLLKAIISFLPFSIPMFGIINFGLSVLCIVLAIQKMKEFDLQQPLEVYSEQDNYFK
>NC_014376.1|WP_013272722.1|2210172_2211603_-|glycoside-hydrolase-family-1-protein
MRFKDNFLWGGSIAAHQCEGAYEEGQKGLGIMDLVTVGAYGKPREIHKQLSGSAHYPSHHGIDFYHRYKEDIALLAEMGFKALRLSIDWSRIYPKGEENLPNQEGILFYQKVVDELKRYGIEPIVTLYHFEMPVHLVSKYGSWANRKVIDYYLTFCRTMFEALKGNVRYWVTFNEMNHIDPQTEASDIFTYMIAGLKYSELENKKQTLATIGYNMTLASCLAVKLGHAIDPQTQIGCVFGIEPVYPIDCNPINVMNAFKQMDRDFYQIDAMCNGQFPSYKIQEYKSQGIKIAVSEEDRQAFRDGTIDFIGMNYYASSVAEYEGSEEGKSALFGGLQNPYLEASKWGWTIDPVGLRYLLNYTYRKYGIPIIVTENGLGAVDQLTENRKIHDEYRMDYLKKHIAQLKKAVEMDQVDCFGYLTWAPIDLVSATTGQMSKRYGFIYVDLNDHGEGSMDRIKKDSFEWFKRVIETNGENLT

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Crispr_ID: NC_014376_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014376_6

3328328-3328442

Orphan

Consensus_repeat	Method
CATTCGCCGTTTGCGCCTACGGGCAGGCTCGTC	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of NC_014376_6

>merge|NC_014376|6|3328328-3328442|CRISPRCasFinder
CATTCGCCGTTTGCGCCTACGGGCAGGCTCGTCCTCGCTCTCTTTCGCTCATTATAGGATGAACGCAAGCGTTCTTCATCGACATTCGCCGTTCGCGCCTACGGGCAGGCTCGTC

>NC_014376|6|5|3328328-3328442|CRISPRCasFinder
CATTCGCCGTTTGCGCCTACGGGCAGGCTCGTC	CTCGCTCTCTTTCGCTCATTATAGGATGAACGCAAGCGTTCTTCATCGA
CATTCGCCGTTCGCGCCTACGGGCAGGCTCGTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_014376.1\|WP_013273692.1\|3334291_3336481_-\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|214599
NC_014376.1\|WP_013273690.1\|3331782_3332490_-\|branched-chain-amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|129446
NC_014376.1\|WP_013273682.1\|3323953_3324841_+\|aldose-1-epimerase-family-protein	unknown	unknown	gnl\|CDD\|185701
NC_014376.1\|WP_081443042.1\|3321613_3322237_-\|transglycosylase-domain-containing-protein	unknown	unknown	gnl\|CDD\|376415
NC_014376.1\|WP_013273678.1\|3319960_3320479_-\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NC_014376.1\|WP_013273680.1\|3320770_3321439_-\|DNA-polymerase-III-subunit-epsilon	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|176648
NC_014376.1\|WP_013273693.1\|3336608_3338486_-\|ATP-dependent-metallopeptidase-FtsH/Yme1/Tma-family-protein	unknown	unknown	gnl\|CDD\|273520
NC_014376.1\|WP_013273677.1\|3318053_3319700_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173883
NC_014376.1\|WP_013273689.1\|3331447_3331786_-\|branched-chain-amino-acid-transporter	unknown	unknown	gnl\|CDD\|224601
NC_014376.1\|WP_013273686.1\|3328460_3329309_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|236216
NC_014376.1\|WP_013273691.1\|3332683_3333592_+\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|224232
NC_014376.1\|WP_013273676.1\|3317046_3318057_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NC_014376.1\|WP_013273683.1\|3325038_3325560_-\|LytTR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197918
NC_014376.1\|WP_013273694.1\|3338509_3339013_-\|flavodoxin	unknown	unknown	gnl\|CDD\|378898
NC_014376.1\|WP_013273688.1\|3330556_3331435_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|225117
NC_014376.1\|WP_013273687.1\|3329325_3330381_-\|mannonate-dehydratase	unknown	unknown	gnl\|CDD\|235172
NC_014376.1\|WP_013273679.1\|3320495_3320675_-\|hypothetical-protein	unknown	unknown	unknown
NC_014376.1\|WP_013273685.1\|3326020_3328060_-\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|214599
NC_014376.1\|WP_013273684.1\|3325742_3325955_+\|hypothetical-protein	unknown	unknown	unknown
NC_014376.1\|WP_013273695.1\|3339204_3340482_-\|glutamate-1-semialdehyde-2,1-aminomutase	unknown	unknown	gnl\|CDD\|234607

Protein	Function_ID	Function_description	E-value
NC_014376.1\|WP_013273690.1\|3331782_3332490_-\|branched-chain-amino-acid-ABC-transporter-permease	gnl\|CDD\|129446	TIGR00346, Uncharacterized_membrane_protein_HI_1738, 4-azaleucine resistance probable transporter AzlC. Overexpression of this gene results in resistance to a leucine analog, 4-azaleucine. The protein has 5 potential transmembrane motifs. It has been inferred, but not experimentally demonstrated, to be part of a branched-chain amino acid transport system. Commonly found in association with azlD. [Transport and binding proteins, Amino acids, peptides and amines].	1.31498e-71
NC_014376.1\|WP_013273682.1\|3323953_3324841_+\|aldose-1-epimerase-family-protein	gnl\|CDD\|185701	cd09024, Aldose_epim_lacX, Aldose 1-epimerase, similar to Lactococcus lactis lacX. Proteins similar to Lactococcus lactis lacX are uncharacterized members of aldose-1-epimerase superfamily. Aldose 1-epimerases or mutarotases are key enzymes of carbohydrate metabolism, catalyzing the interconversion of the alpha- and beta-anomers of hexose sugars such as glucose and galactose. This interconversion is an important step that allows anomer specific metabolic conversion of sugars. Studies of the catalytic mechanism of the best known member of the family, galactose mutarotase, have shown a glutamate and a histidine residue to be critical for catalysis; the glutamate serves as the active site base to initiate the reaction by removing the proton from the C-1 hydroxyl group of the sugar substrate, and the histidine as the active site acid to protonate the C-5 ring oxygen.	1.00506e-125
NC_014376.1\|WP_081443042.1\|3321613_3322237_-\|transglycosylase-domain-containing-protein	gnl\|CDD\|376415	pfam00912, Transgly, Transglycosylase. The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyzes the polymerization of murein glycan chains.	1.5605e-74
NC_014376.1\|WP_013273678.1\|3319960_3320479_-\|N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	4.38624e-08
NC_014376.1\|WP_013273680.1\|3320770_3321439_-\|DNA-polymerase-III-subunit-epsilon	gnl\|CDD\|176648	cd06127, DEDDh, DEDDh 3'-5' exonuclease domain family. DEDDh exonucleases, part of the DnaQ-like (or DEDD) exonuclease superfamily, catalyze the excision of nucleoside monophosphates at the DNA or RNA termini in the 3'-5' direction. These proteins contain four invariant acidic residues in three conserved sequence motifs termed ExoI, ExoII and ExoIII. DEDDh exonucleases are classified as such because of the presence of specific Hx(4)D conserved pattern at the ExoIII motif. The four conserved acidic residues are clustered around the active site and serve as ligands for the two metal ions required for catalysis. Most DEDDh exonucleases are the proofreading subunits (epsilon) or domains of bacterial DNA polymerase III, the main replicating enzyme in bacteria, which functions as the chromosomal replicase. Other members include other DNA and RNA exonucleases such as RNase T, Oligoribonuclease, and RNA exonuclease (REX), among others.	2.95307e-56
NC_014376.1\|WP_013273693.1\|3336608_3338486_-\|ATP-dependent-metallopeptidase-FtsH/Yme1/Tma-family-protein	gnl\|CDD\|273520	TIGR01241, ATP-dependent_zinc_metalloprotease_FtsH, ATP-dependent metalloprotease FtsH. HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides].	0
NC_014376.1\|WP_013273677.1\|3318053_3319700_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|173883	cd08518, PBP2_NikA_DppA_OppA_like_19, The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold. This CD represents the substrate-binding domain of an uncharacterized ATP-binding cassette (ABC) type nickel/dipeptide/oligopeptide-like transporter. The oligopeptide-binding protein OppA and the dipeptide-binding protein DppA show significant sequence similarity to NikA, the initial nickel receptor. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	0
NC_014376.1\|WP_013273689.1\|3331447_3331786_-\|branched-chain-amino-acid-transporter	gnl\|CDD\|224601	COG1687, AzlD, Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism].	1.95823e-26
NC_014376.1\|WP_013273686.1\|3328460_3329309_-\|SDR-family-oxidoreductase	gnl\|CDD\|236216	PRK08277, PRK08277, D-mannonate oxidoreductase; Provisional.	1.24182e-166
NC_014376.1\|WP_013273691.1\|3332683_3333592_+\|radical-SAM-protein	gnl\|CDD\|224232	COG1313, PflX, Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins [General function prediction only].	3.83483e-98
NC_014376.1\|WP_013273676.1\|3317046_3318057_-\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	2.09741e-96
NC_014376.1\|WP_013273683.1\|3325038_3325560_-\|LytTR-family-transcriptional-regulator	gnl\|CDD\|197918	smart00850, LytTR, LytTr DNA-binding domain. This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.	2.67656e-13
NC_014376.1\|WP_013273694.1\|3338509_3339013_-\|flavodoxin	gnl\|CDD\|378898	pfam12641, Flavodoxin_3, Flavodoxin domain. This family represents a flavodoxin domain.	4.12522e-56
NC_014376.1\|WP_013273688.1\|3330556_3331435_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	1.78469e-21
NC_014376.1\|WP_013273692.1\|3334291_3336481_-\|HAMP-domain-containing-protein	gnl\|CDD\|214599	smart00283, MA, Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.	3.30013e-56
NC_014376.1\|WP_013273687.1\|3329325_3330381_-\|mannonate-dehydratase	gnl\|CDD\|235172	PRK03906, PRK03906, mannonate dehydratase; Provisional.	0
NC_014376.1\|WP_013273685.1\|3326020_3328060_-\|HAMP-domain-containing-protein	gnl\|CDD\|214599	smart00283, MA, Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.	3.0743e-58
NC_014376.1\|WP_013273695.1\|3339204_3340482_-\|glutamate-1-semialdehyde-2,1-aminomutase	gnl\|CDD\|234607	PRK00062, PRK00062, glutamate-1-semialdehyde 2,1-aminomutase.	0

>NC_014376.1|WP_013273685.1|3326020_3328060_-|HAMP-domain-containing-protein
MKTSGEKKRNLKALLTAKRVKLEKKGNKSQFLKSLKMKMLAFIIAIILGLAVTNMAISISVSYKGITDVVKNDLESTGKLVNSLVVQNLNQMKVSIEASSQGGSLKSINSRVVTEYLSNQCKLYGYKDLQVINKDGTITRSASGENIGDVYPAADYLTRAMNGETTISTTEFDNNNELVIRVAAPYEYGVLLGTYDGAVLSSLISDLRIGESGNAFIIDNTGTMIASMTPELVQSRQNFIELGKTDKSYASAGNMFQTMLNGKTGIGRYEYNGEDRFCYYSPVTGSDGWALGVVASVKETTSSIYLVVFAMTAFALVSVVIGSILAFWFAGSIAGPVSAIAARMKLFTEGDLSSEVPVVKRRDEIGQLADEIASSVHSVKSYISEIASVLGNIASGDFSQSVGMEFQGDFKVIQDSIDRTEDLLSKTMETISISADEVAKGSTQVSQGAQNLSQGSVEQAASVEELSSSVNEISGSLISTAKAVEDVNKQAGRVGQAMESGNAQMHEMMQSMDQINKKSKEIEKVNKLIEDIAFQTNILALNAAVEAARAGEAGKGFAVVADEVRNLAGKSANAAKDTSSLVADTIAAVNKGTGIAASTGETLNGVLSETKSMVSAIRNSAEELKEQSEKVTQVTYGIEQISSVVQNNSATAEESAAASEELSSQAESLRELMSKFRLR
>NC_014376.1|WP_013273684.1|3325742_3325955_+|hypothetical-protein
MKSENKNENQKKKTESTTSKNNYDIDIQACSTMDCTGLIPSAPQSEAELESYEDLYPFMPHSKNVDKDSR
>NC_014376.1|WP_013273683.1|3325038_3325560_-|LytTR-family-transcriptional-regulator
MRIAFFTNEKQTQGLEYVYPGTWNSRLKVDYFSIKEGHFTTLGCSVYDMIVIYPKGNSSLHPTKYPVFFNGQSAILDIRDILYLESYYRKTSVVAGSGRMRIRARLDEEEEKLPKDRFVRINRHNIINMHYVRSVRGEAVEMQNGEVLYVNDGRRKKFENRYREFLKENCLSL
>NC_014376.1|WP_013273682.1|3323953_3324841_+|aldose-1-epimerase-family-protein
MLVTLHDTKATAVIDSIGAQLLSFKDSAGTEYIWQRDPEFWSKCSPLLFPIVGNCRNNQTRLEGRTWEIPKHGFCREADFAVTQQAKTSAAFEIRDTEETKRFYPYSFRLSLSYTLIDGSLYMEYQVFNTEERTIYYCLGAHPGFNCPMENGASLEDYDLVFEKEETISSMVYDCKNLEFNPGNRISRLKESRILSLNRELFKDDAVYFDDLKSRAVSIINRNTGRGVEVSFPGFETVAFWSPYPGEAPFVCVEPWNGSAIYATEDDEFIHKNHVQTLKPGKAKSYGLSIKILNE
>NC_014376.1|WP_081443042.1|3321613_3322237_-|transglycosylase-domain-containing-protein
MYRNALSEAGLQERVEAVRDKEGYTEYKNLPQIYVNAVVSVEDHRFYRHHGIDLIAIARAVTNDIRAGKLVEGGSTITQQLAKNLYFDQDKDIARKAAEVFMAFDLEKNYTKEEIFELYVNCIYFGDGYYSVGDASAGYFKKTPDEMSEYESTLLAGVPNAPSKYAPSKNQALAEKRQMKVLRRMEECGYFSAEEAETVAEQMVAFQ
>NC_014376.1|WP_013273680.1|3320770_3321439_-|DNA-polymerase-III-subunit-epsilon
MAVRQFTGRRLNQYAENYVVFDLETTGISPAEDSILEISAIKVKGHEPVAELNTLVNPGTHIPAGATRINGITDDMVKAAPGLKEVLPDFLSFIEGEILVGHNIQSFDLLFLYRAAQELFGKEVPNDYVDTLFMAKTTLPQLGRHRLTDISAYFHINTEGAHRALSDCVMNQKCYEQMGKLVHKEEAEICPQCGSVLKRRSGKFGEFYGCSNFPQCRFTRNV
>NC_014376.1|WP_013273679.1|3320495_3320675_-|hypothetical-protein
MYNRIMLIAFCLIMILLCAGAYSWFHGGDALPDMEVPREKVQVLHWVNWEPAELPDAVI
>NC_014376.1|WP_013273678.1|3319960_3320479_-|N-acetyltransferase
MNFLIERAVHEDYQIMADVIQSVWRQIERKDWFVADDSEYTCHTLQEGNGIGYKAFEMETNALAGVLIASLPGKGEENLGWDIGMAEEELGRVAHMESVAILPKYRGNGLQHTLMKIAEEELRNHGYRYLMCTVHPENKFSKNNMIKQGYQVVLTKEKYGGYLRDILYKELL
>NC_014376.1|WP_013273677.1|3318053_3319700_-|ABC-transporter-substrate-binding-protein
MMKRKWGIAAAVLMTAVVLNGCGKADSTQASGKTGTATEAAGTDSDGEKDRVVVVMGVSSEPEAGFDPAYGWGAGEHVHEPLIQSTLTITDKDLNIGYDLATDMQASSDGLTWTVKIRDDVFFTDGEKLTGQDVAFTYNTLRDTSSVNDFTMLDRAEAPDDTTVLFHMKHPYSIWPYTMAIVGIVPEHAYGPDYGEHPIGSGRYLLKQWDRGQQVILEANPDYYGEAPRMKRVTVLFMEEDGALAAVRSGQADVAYTAASYSDLTIPGYGLLDCKTVDNRGFNLPVIPSGSISESGVPLGNDFTSDVRVRRAINMGIDREEMIDHVLNGYGSPAYSVCDKMPWYEPSAKTEYDLEGAEALLEEAGWKKGGDGIREKDGKRAELHFLYPAGDSVRQALAADTINQLKKIGIDGQMEGAGWDTAYDRAQTQPLIWGWGAHTPMELYNIYHTMKETGLAAYSPYANEKVDQYMDEALAQSNLEKSYELWKKAQWDGENGIIQSGDIPWIWLVNIDHLYWVRDGLKVADQKLHPHGHGWSIVNNVDQWRWGS
>NC_014376.1|WP_013273676.1|3317046_3318057_-|ABC-transporter-permease
MKDGRSGRKILCFLVKQLARMAVLLFLVSAAAFFLVSVSPIDPLKVNVGQAALGSMSQEQIAKLSQYWGTGLPPAERFLSWAGDFIRGDLGTSLLYRRPVSQVIGVKLRNSLWLLAISWAVSGIVGFALGTLAGANRGKAVDKVISAYALITASTPAFWLALVFLIVFAVRLQVLPIGLSVPIGMEAAEVTLKDRVVHGILPCLTLTISGMSGILLHTREKMIQVMESDYVLFAKARGESKSRIVFHHGIRNVLLPALTLQLASVSEIFGGSVLVEQVFSYPGLGQAAVTAGLGGDVPLLLGITVISASIVFTGNFIANVLYGVVDPRMRRGRVGT
>NC_014376.1|WP_013273686.1|3328460_3329309_-|SDR-family-oxidoreductase
MSLSFGTDLSGKVAVVTGAGGVLCGMFAKTLAKAGAKVAVLDLNEHAAEEVAASIHEAGQMAKAYKVNVLERASLEEVHAKVLAELGPCDILINGAGGNNARANTDKEYFEMGDIEADTKSFFDLDPSGVEFVFNLNFLGTLLPCQIFAKDMIGREGCSILNISSMNAFTPLTKIPAYSGAKAAISNFTQWLAVHFSRVGIRVNAIAPGFFVTKQNEKLLFNEDGTPTPRTNKILSATPMGRFGEAEELNGALLFFLNNEAAGFITGVVLPIDGGFSAYSGV
>NC_014376.1|WP_013273687.1|3329325_3330381_-|mannonate-dehydratase
MKLSFRWYGDDDKVTLQDIRQIPGMYSIVTAVYDVPVGEVWSRESIAHLKKETEKAGLAFEVIESIPVHEDIKLGKSSRDRYIANYCENIRRVSEAGIKCICYNFMPVFDWTRTQLDHVLEDGSTSLVYYQEQVDKVNPLESESDLTLPGWDSSYTRDELKQVVSEYNAMSEDDLWDHLKYFLEAIIPVAAECGVNMAIHEDDPCWSIFGLPRIITCEENLDRFLTLVDDKHNGITLCTGSLGCSNQNDVVKMAAKYAAMGRIHFVHARNVAVLENNQGFEERAHLSSCGSLDMFAILKALHDNGFDGYMRPDHGRMIWGETGRAGYGLYDRALGATYLNGLWEAIEKMSK
>NC_014376.1|WP_013273688.1|3330556_3331435_+|helix-turn-helix-domain-containing-protein
MRKELSTGFNQRQYMNSGEYEVFFYKDLDLDHVVDHSHSYYEVYFFLNGDVSYEVEGTQYRLQYGDYLLIPPEVKHHPVFHSTGKTYQRIVLWISRNYFETMCSWSEDFSYSFRYVQESRHSHFRTDFVTFQNIQGRLLDLLEEIHGNKAFHMLNAELQIHSFMLLLNRITYDMLHKVPAAYENALYLNICDYINNHLEENLSLDHLASFFYASKYHISHVFKDNMGISLHQYIIKKRLQASKNGILSGIPFGELYHQYGFSDYTSFYRAFKKEFGLSPKEFREQAVLPKGY
>NC_014376.1|WP_013273689.1|3331447_3331786_-|branched-chain-amino-acid-transporter
MNQNLTANILLAAAMVLATVITRFLPFILFPAGKKTPRYILYLGQTLPYATIGLLVVYCLRGIKLLLYPHGLPEIISIAAIAWLHLRKGNPLLSIGVGTALYMVLIQGVFHS
>NC_014376.1|WP_013273690.1|3331782_3332490_-|branched-chain-amino-acid-ABC-transporter-permease
MRETKKMAALRYAFPKTMPVMAGYLVLGAAYGILMNVNGNGIWWALLISVFVYAGSLQYLGITFFAAAVNPWYAFFMSLMLNARHLFYGLSMLDKYKAAGKLKPYLVFALTDETFSVLCNEEVPEGLPKDWVYFFVSILDQIYWVTGAVIGALAGSMIRFNTAGMDFALTALFVVIFIDQWKSGKGRPAACVGVGASVLCVAVLGQSVFIIPAMILILTVITAGYYREKKKEEQS
>NC_014376.1|WP_013273691.1|3332683_3333592_+|radical-SAM-protein
MNLTHIYESCCLCPRNCRVNRYANTGYCGCGHTVKAARAALHHWEEPCISGTRGSGTVFFSGCTLGCCFCQNYSISQENFGREITSKELSHIFLRLQEKGAHNINLVTATQYLPSILEALDLIKSSLFIPVVYNCGGYESEEIVKELSSYVDIWLPDLKYFSTELSSRYSKAPGYFEAASKAIKQMILQTGAPQFDSHGDIMKKGVIIRHMVLPGAKEDSIRLLHWMKETLPEGMYYISLMSQYTPFYKSGNFPEINRRITSYEYGKVVDEAIRLGLDQGFMQEKSSAKEEYTPPFDLEGIE
>NC_014376.1|WP_013273692.1|3334291_3336481_-|HAMP-domain-containing-protein
MKEQIFRKWRNRDSGYKGTSWLTKMGIGKHHLSTRIACIAGILLVVVFAALIGITSRMTKSVMKQSAFRELKTLASENGKVIQQTLDEASQVSENITYYLENSAANRKVLQGLRIKSGPSAEPLYKSQIFDSVTLDSYGMKMEDYMLTTIKSSVLYSQDIVGVGILFEQYAMSSAARSYGLYAGKDGTVRDCGLYEDYSTADYFVKAMEQKAQVITLPYESNGMMIITMAMPVIVNDRVLCVVAVDVGLDRFSQIKTAGSSYPSMQTFILNESGTIISESTGSGLVGTGVSDFVNSKSCKEEITSGISSGSDFYTVDAGKKGDTYYFFEPIQLKGSNWYSVTAVEAGDMNREANRMSSLMAVISIIAMVVILFIITVVITRQLKPILKIVTAAGKIAEGNLDVCVDVESNDEIGLVASSFERMTVNLKEVIDRISFALKEVADNHLDFDVELGLKGDFSQLEAAVKQIVKNLNAVMNDVNQAASQVAVSSGQVASGSQLLANGAEEQEKTVDMLSGSISQVADKVKRLADKAGEVSMQVQQTGTEVVSCDMSMQNLSNAMNEIHASSGEIGKIIKVIEDIAFQTNILALNAAIEAARAGESGRGFAVVAGEVRNLAAKSSEAAKNTTALIRDSINAVEKGNEILAETVQSMMKVLEDSALAVDSVDSISAIAAQEAKSVEEVTKELGRISSVVQNNAAAAEESAASSEELSQQAQLLRELVLSFRLRES
>NC_014376.1|WP_013273693.1|3336608_3338486_-|ATP-dependent-metallopeptidase-FtsH/Yme1/Tma-family-protein
MGLKDDGNSQKNPKRPFIYYYAIVLLVMIVFNAMTVPWLQSKTVNEVPYSTFLEMVDQGKVQAVAKTETEIQFKSDTGKKDWEGKPVYDVYKTGLWPDETLTERLLAHNVSFEKAIVKQMSPLLSFLLTWIIPILIFVFLGNFLSGQMQKKMGGGNAMTFGKSNPKIYAESETGKTFRDVAGQEEAKEALKEIVDFLHNPQKYADIGASLPKGALLVGPPGTGKTLLAKAVAGEAHVPFFSISGSEFVEMFVGMGAAKVRDLFKQAGEKAPCIVFIDEIDTIGKKRDGGGFTGNDEREQTLNQLLAEMDGFDGRKGVVILAATNRPDSLDKALLRPGRFDRRIPVELPDLIGREAILKVHGKNVKLSDDVDFHGVALATAGSSGAELANIINEAALRAVRMGRKTVTQRDLEESVEVVIAGYQKKDSSVSSRERKIIAYHEVGHALVAACQNHSAPVHKITIIPRTSGALGYTMQVDEEERYLLTKEAALSKIATFTGGRAAEELIFQTVTSGAANDIEQATRIARAMVTRYGMSDEFDMVALETVTNQYLGGDTTLACSPETAKRIDDAVIRIVKEQHQKALNILKDNETRLHEIAKYLLERETITGEEFMKIAGFDLAEAQES
>NC_014376.1|WP_013273694.1|3338509_3339013_-|flavodoxin
MDYLVVYTSNTGNTQKVAMRIFETLPGKSKDIVSLEELHGEEADTYFVGFWNNRGTCKTEVLDFLSDLHGKRVALFGTCGLSGNKEYYKQVEKQVAVFLPDDNEYLGCFLCGGKMAPQILEKYRQMQAIHDTPQIRTLISAYEDGMLHPNQQDFKDAEEFVKSVLKE
>NC_014376.1|WP_013273695.1|3339204_3340482_-|glutamate-1-semialdehyde-2,1-aminomutase
MKIEESKVLFEKSREYFPGGVNSPVRAFGSVGGVPVFVKRASGSHIYDEDGNEYIDYVNSWGPCILGHAWGPVVEAVREACLDGLSFGAPTRKELVLGGLIRECMPSMEMMRMVSSGTEAVMSAIRAARGYTGRDKIIKFKGCYHGHSDGLLVKAGSGALTGSAPDSAGVPASYTEHTLLAQYNDESSVKKLFSEYPDDIGALVVEPVAANMGLVPPKPGFLEFLRDITAKYGTLLIFDEVITGFRMGLGGAQGYYGVVPDLTTLGKIAGGGMPMGVYGGKREIMEVVSPLGRVYQAGTLSGNPVATAAGIATIRALMERPEIYPTLEERAGRLVKSLREALPDTWVNQAGSLFSLFFTKNPVVDYDTALASDTVKYGIFFHYLLDHGIYTAPSQFEILFLSAAHTDEDIEKTCGIIKKAAGSLS

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Crispr_ID: NC_014376_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014376_7

3788035-3788159

Orphan

Consensus_repeat	Method
CTCTATGGTCAGGCTATCAGCATACGCGCCGTAGCTTT	CRISPRCasFinder

1 spacers

DinG

The CRISPR arrays of NC_014376_7

>merge|NC_014376|7|3788035-3788159|CRISPRCasFinder
CTCTATGGTCAGGCTATCAGCATACGCGCCGTAGCTTTCGCCGCTTTGATATGTTACCGCACCGCCGTTGGCGGTCAGGCTGCCCCCCTCTATGGTCAGGCTATCAGCATACACGCCGTAGCTTT

>NC_014376|7|6|3788035-3788159|CRISPRCasFinder
CTCTATGGTCAGGCTATCAGCATACGCGCCGTAGCTTT	CGCCGCTTTGATATGTTACCGCACCGCCGTTGGCGGTCAGGCTGCCCCC
CTCTATGGTCAGGCTATCAGCATACACGCCGTAGCTTT

Protein	Signature genes	Signature genes Name	Protein_function
NC_014376.1\|WP_013274091.1\|3778787_3780764_-\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|277343
NC_014376.1\|WP_081443100.1\|3767315_3769346_-\|ATP-dependent-DNA-helicase	DinG	COG1199_DinG_CAS-IV-A	gnl\|CDD\|224120
NC_014376.1\|WP_013274105.1\|3796259_3796988_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225818
NC_014376.1\|WP_013274090.1\|3778487_3778703_-\|hypothetical-protein	unknown	unknown	unknown
NC_014376.1\|WP_013274104.1\|3795948_3796239_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379188
NC_014376.1\|WP_013274102.1\|3793069_3793474_-\|hypothetical-protein	unknown	unknown	unknown
NC_014376.1\|WP_013274101.1\|3792596_3793019_-\|acid-shock-protein	unknown	unknown	unknown
NC_014376.1\|WP_013274095.1\|3784403_3786641_-\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|378188
NC_014376.1\|WP_013274099.1\|3790245_3791931_-\|DUF2207-domain-containing-protein	unknown	unknown	gnl\|CDD\|378333
NC_014376.1\|WP_041708691.1\|3783397_3783904_-\|RNA-polymerase-sigma24-factor	unknown	unknown	gnl\|CDD\|224511
NC_014376.1\|WP_041709424.1\|3782953_3783136_-\|DNA-binding-protein	unknown	unknown	gnl\|CDD\|378935
NC_014376.1\|WP_013274088.1\|3770097_3770592_-\|RNA-polymerase-sigma24-factor	unknown	unknown	gnl\|CDD\|369791
NC_014376.1\|WP_013274092.1\|3780927_3782214_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|340412
NC_014376.1\|WP_013274103.1\|3793646_3795650_-\|SH3-type-3-domain-containing-protein	unknown	unknown	unknown
NC_014376.1\|WP_013274089.1\|3771095_3778469_-\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|197609
NC_014376.1\|WP_013274106.1\|3796989_3798261_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|340412
NC_014376.1\|WP_013274093.1\|3782210_3782948_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225818
NC_014376.1\|WP_013274097.1\|3789095_3789275_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236478
NC_014376.1\|WP_013274098.1\|3789312_3790221_-\|DUF4428-domain-containing-protein	unknown	unknown	gnl\|CDD\|373083
NC_014376.1\|WP_013274100.1\|3791939_3792494_-\|LemA-family-protein	unknown	unknown	gnl\|CDD\|224618

Protein	Function_ID	Function_description	E-value
NC_014376.1\|WP_013274091.1\|3778787_3780764_-\|metallophosphoesterase	gnl\|CDD\|277343	cd07398, MPP_YbbF-LpxH, Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain. YbbF/LpxH is an Escherichia coli UDP-2,3-diacylglucosamine hydrolase thought to catalyze the fourth step of lipid A biosynthesis, in which a precursor UDP-2,3-diacylglucosamine is hydrolyzed to yield 2,3-diacylglucosamine 1-phosphate and UMP. YbbF belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	1.24183e-10
NC_014376.1\|WP_081443100.1\|3767315_3769346_-\|ATP-dependent-DNA-helicase	gnl\|CDD\|224120	COG1199, DinG, Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair].	9.48727e-87
NC_014376.1\|WP_013274105.1\|3796259_3796988_+\|response-regulator-transcription-factor	gnl\|CDD\|225818	COG3279, LytT, Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms].	9.78502e-26
NC_014376.1\|WP_013274104.1\|3795948_3796239_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|379188	pfam13443, HTH_26, Cro/C1-type HTH DNA-binding domain. This is a helix-turn-helix domain that probably binds to DNA.	1.20555e-18
NC_014376.1\|WP_013274095.1\|3784403_3786641_-\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|378188	pfam09479, Flg_new, Listeria-Bacteroides repeat domain (List_Bact_rpt). This model describes a conserved core region of about 43 residues, which occurs in at least two families of tandem repeats. These include 78-residue repeats which occur from 2 to 15 times in some proteins of Bacteroides forsythus ATCC 43037, and 70-residue repeats found in families of internalins of Listeria species. Single copies are found in proteins of Fibrobacter succinogenes, Geobacter sulfurreducens, and a few other bacteria.	9.64713e-16
NC_014376.1\|WP_013274099.1\|3790245_3791931_-\|DUF2207-domain-containing-protein	gnl\|CDD\|378333	pfam09972, DUF2207, Predicted membrane protein (DUF2207). This domain, found in various hypothetical bacterial proteins, has no known function.	9.31697e-14
NC_014376.1\|WP_041708691.1\|3783397_3783904_-\|RNA-polymerase-sigma24-factor	gnl\|CDD\|224511	COG1595, RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription].	3.85546e-05
NC_014376.1\|WP_041709424.1\|3782953_3783136_-\|DNA-binding-protein	gnl\|CDD\|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	0.00160532
NC_014376.1\|WP_013274088.1\|3770097_3770592_-\|RNA-polymerase-sigma24-factor	gnl\|CDD\|369791	pfam08281, Sigma70_r4_2, Sigma-70, region 4. Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 promoter element via a helix-turn-helix motif.	9.97503e-05
NC_014376.1\|WP_013274092.1\|3780927_3782214_-\|sensor-histidine-kinase	gnl\|CDD\|340412	cd16935, HATPase_AgrC-ComD-like, Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing. This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.	2.24758e-28
NC_014376.1\|WP_013274089.1\|3771095_3778469_-\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|197609	smart00257, LysM, Lysin motif.	2.32603e-11
NC_014376.1\|WP_013274106.1\|3796989_3798261_+\|sensor-histidine-kinase	gnl\|CDD\|340412	cd16935, HATPase_AgrC-ComD-like, Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing. This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.	1.14607e-30
NC_014376.1\|WP_013274093.1\|3782210_3782948_-\|response-regulator-transcription-factor	gnl\|CDD\|225818	COG3279, LytT, Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms].	4.34312e-23
NC_014376.1\|WP_013274097.1\|3789095_3789275_-\|hypothetical-protein	gnl\|CDD\|236478	PRK09356, PRK09356, imidazolonepropionase; Validated.	0.00449925
NC_014376.1\|WP_013274098.1\|3789312_3790221_-\|DUF4428-domain-containing-protein	gnl\|CDD\|373083	pfam14471, DUF4428, Domain of unknown function (DUF4428). This putative zinc finger domain is found in uncharacterized bacterial proteins.	2.22716e-08
NC_014376.1\|WP_013274100.1\|3791939_3792494_-\|LemA-family-protein	gnl\|CDD\|224618	COG1704, LemA, Uncharacterized conserved protein [Function unknown].	2.76923e-43

>NC_014376.1|WP_013274095.1|3784403_3786641_-|LysM-peptidoglycan-binding-domain-containing-protein
MVGDVAPGTVWDNSTALSTYKYVQLVVVPVAPTPNLSVADVTLDAVTVGYDRTTYKSIVITNSGDAQATITNVTTDHPFVFSIHRGQDFVAAGSSINSWDIRAATGLAVGTYTTTITVTYDGGRTATATVSITVNAVGNYTVTFNPNGGTVSETSRSVAPGTAVGALPTPTRSGSYSFDGWYTAASGGTQISASTTVSANVTYYAHWSNTGGGGSGSGGGSSSNDNSSPVIVTPPAPDKPNSPTQGEIKVSGTVDSKGNVTVNISDKTVTDAFEKALADAKKNGNEQNGITVILRVDTSSKTGSNVTVNLPKTVQDTIIAKKIVNTIVVVDNPDIRIGMNLATVQEINKQAKSDVNITATRGDSSKLTGDAKKAIGSRSVFDLKVNYGNGKEVSSFGTGSVSVTIPYTLGANEKAGNVQAVYVDAKGKVHWLTNSVYDSVAQVLRFSTDHFSTYGIGYKQTNTAFTDIAAHWAKEDIEFVVSRGLFSGTSNTTFSPNTAMTRGMFVTALGRLANADVNGYTKSSFTDVKNDAYYMNYIEWASNNNIINGVGNGKFAPDQSITREQMAVIMSNYAKTIGYTLPKVHIENIFTDNAKISTYAKEDVKQMQMAGVISGKNGNLFDPQGTATRAEVSAVLRRFVELVISSSTAQGWSMNDSGKWMYFKDGKPLTGKQDIDGATYTFDQYGVTADVPKNLRYTTYTVQKGDSFWSISRKLGCPMSELERLNNKSRFSLIIPGDVLRVPEK
>NC_014376.1|WP_041708691.1|3783397_3783904_-|RNA-polymerase-sigma24-factor
MKNYKDSDYALNKFSEGIVYRFADRIVEITLEDYLAENPGKTAQDFLELKALSDEIYHEQVTHENRTSRLDVSINGLEETEQLAAPPLDLDLIHKNDTQKAKEAARRLLDSGELTEIQRRRFLLHFVEGLSYRQIAGREGVPFTSVHESIEAATAKLQKFFKSLILYL
>NC_014376.1|WP_041709424.1|3782953_3783136_-|DNA-binding-protein
MQEYISAREASYKWGVSERRVHQYCQAGRIPGVYRFGRSWAIPADAQKPTDPRKENTIRK
>NC_014376.1|WP_013274093.1|3782210_3782948_-|response-regulator-transcription-factor
MLRIAICDDQPRELEVINEYITEYLDTHILEAEIKEFSHPDKLLTAIETESFHFYILDIVMPMVSGLELGKEIRRFDREAQIIYATTEPQFALQAYAASPINYLIKPIEKQQLFDTLTLAISKTDLAEDQTFAVKTAESLRVMKLSDIICCEYRSHAVIFSLANGEEVSSRTFRENFSEYCASILKDRHFLQCHTSFIINMRRVERFAKDNFTLYGGKIVPIAAKQYPVARDAYMDYLMAKEVCR
>NC_014376.1|WP_013274092.1|3780927_3782214_-|sensor-histidine-kinase
MSEHFPDFLRAVISTTANVLLMMTLLQPKYSKKVTLLTMLGILAADLGTAVYCYLSGNLTLLAKLDIVLFAVLCFAVRPIFKDTFMQWLFSYITVQNISDAVIILSFVGSRHLPYPPYANSLLRLLLFGVFLLVLVRHVRPLYRQAVEHWTAYFAVALGLYITFTYYVLSTDDIVVMLTEQAVPLLLVIFIGLAAYGSIFLSLKNLQREYRVREENQRMQAEREYLQLAAGNMSQRLALMEEVSAQNSRAAHDRRHFNNVLQELLEQGETVEAFALLQSQNQVKHKISKVYCENPAVNAAVCHYAERAEQSGILTEIELDIPRELTVNSLELSMVVSNLLENAIAACIKQSGSKPLFIHFICRNMGRLLLEIENSCTEDTALDEDSYPVSMEEGHGIGSKSVIAFAKKYDGELIYNIENGVFRVRLLV
>NC_014376.1|WP_013274091.1|3778787_3780764_-|metallophosphoesterase
MRKRILSFLLASCMVLSLALLATGCSNKAGPLALWDAGKKRDKIVVISDLHIGIDDNYAETVQNRPLLIEFLQRLQRTTDVRELVIDGDFLDEWFLPVYYPSYTDEKQFYKAVIANNQGVIDELNNVIKSGIKLVYVIGNHDMTLEADVLKEAIPKIVQARDAEGLGTYYTGDRNEIAIEHGHRYDVFSAPDTVTNAKLCGNEDTIFPAGYFYARYAATWVLEGRPKVEKNLPVVTNVPDKTNVDQYGAYIYYSILKNVSERMTPNENLDEKIFDMHIAGFDYAYTYLDFYPVQQADGTISAPVLFQNIQRTWDERQKINQVKVPNSFLEAVAGTLDWEYFFRQAKVQYLENPNENVDVVVFGHTHVPSYRDMGNGKYYINEGTWIDHNTDYPEATRTFAVITTGEKTIPALYMYNEDGSVTDIAASVSGEKGEAAPAANPLDNVSFDTKALENYGDTDTQARYVEVSGLADGGVQAKLNKGLKAFCLAPTSSAEKDTTYDIMPIFEVVGGDLLSIRTYNTAYTAGAAYPVNSIQTQLFSLTTGGQDAGNLWDFIKDKGAFKQLILDGKFGFAAAGVDGALPEELKAAAYKKLAESIDTPEFGMRFYFGDGGNLNLWCDGDNHATGDYWLFDIPVMDLASVATDRLLPIIDAMKNLGN
>NC_014376.1|WP_013274090.1|3778487_3778703_-|hypothetical-protein
MEKRRREDAPLSAPNAEGNVWPKQVCPAFEPRADTPEGMRQCWYCRCADFHLDKPRSLDVGVCYWPRKILK
>NC_014376.1|WP_013274089.1|3771095_3778469_-|LysM-peptidoglycan-binding-domain-containing-protein
MKKRILSIWLSVCMVLTMLPISAMAEQSGTPIGAKGEIIAFAPLDETERSVSTGTAMEDLGLPESLTATVRTAVTADSGTSEDAVHDSGNPDKGSVSGNLAEATPGSAAPTDSDGQSETDKVTGVEWKETTVDIPVTWTSEPEYDMDTEGVYVFAPVIEGYAVSAELPEITVTVSTQPLMMALRGGTPTTYGDFSVTVDEDGAAPIFANGILTFGTAGEYTIGMIEGKTSTSNVIVVSASDVMLNLDGVTIEAPDGSAAKVDGGNALTVTSDSVILNLLNDSSFTGGIGGIVDPMNACNGGSGISGNVTLTGTATLTATGGIGGAAALGTSGTGGAGISGNVTVTGAAALTATGGIGGAAALGTSGIGGPGISGNVAATDSASLIAIGGQYGGGIANGGSGISGSLTVTDYATVSLEGGLSLSTPGSALTGTLTATGFIIKGGYFSEMDVITSDDYRLNQFRYLSVAPAPNVAEIGSTGYPTLQAAVDAVDEGQTIKLTDAITITDSSSITINGANSFTLDLNGKTLADDGSGSTSLIKHNGSGTLTIQDSGTGGKMTSSRSVGSNGGTVELSGGNGALTLLSGTIENTSASGAGIFNNGTGTVSIQDGIVRAEACSVNNKSGNVSVSGGVVSANKYLSAAILSSAGKVTLSGGSIYNPTYVGVGLSNSSLVVSSGSPIIQGGVAAMNAAPTVDSDTIAKVIASTNYDGNNPVENYNASQITSYKYLTFAVKIPPATFDFCNGIATVSVKPSSDPAWGGTGYAFAGWYTAPNGEGTALTGDGDSGITYYAKWTYNGHTVRTTALNLTDISTSKLYGSTQNGNVYTNTAEGWTWYAVQTTVGSEIYAANTLVLSDLTLNTTAPTALKVPSSATVVLGDGTTSTIQSGNVTAGAVYGIYGAGDLTVSGGGALSVTAGDSGFDEDDQSIGILSSGALTVNGGTVTSISGKAVESYGMMSVGTLTIDSDAVTGAGGLSVAGAGIFSLDNLTITGGTIAGSSDGMLAGYGIFATGEIAITGDTVTGNGGGIMGCGISADEISITGGTVTAKNNAIDGDGNPLSAATAIETTTTLTIGSSAKSAAIANATDGTSAITASGGTVASKKLVMSGSDAVVISFALPTAAQYAAASPAAAPDTDYVLDTSGKTLTIKTAKGAAWWSANGSTYRDYTIKLDADIDVSGFLWTPVGNDAGVFGGTFDGQGHSLSGLTITAANGGYTGLFGSALSATIQNLCVSGTINVTETGGSLYMGGIAGGIGGNSTIRNCGSHVNIRGTASNGDEVNAGGIVGYLSSGTIENCFNTGDVFGTGAAMVIAGGIYGANSQYTSNIGTVKNSYNTGSVTGSGSSINWIGALAGSVDSNTVFEHSYYLVGTATAASGHGSGTGYSSFAAGTADGLITALNGWVSEKASTAYSTWQADNADSPVNGGWPVFGAAWTAPPAPTIGTLTISDSFTAGNGIQPSGLTSYKPTVTSNGVDLTAEGWQSSITFSGDSDDWENWPDGTILSPTTTRIYKLRYYVTYDSTTIYSNAVTLDVVGHTTTLALAASPESPQIVGSSITLTATLTGYFTGPGVNGQAITFKNGSTDLGTANLNASGVAVFTWTPGGTGTCVLTAEYAATAYNTAAASSTVNYIVIVDPDIAIVAAAKTAAQGTSYADMTQTAATDEDAIKAALKNTAETAVNNSDITVTINKVSYIAPIAGTPANPSGTNGSYTFTVTVSKGSQSDTTVQKTIVITATPYTGVTDAQAVSAAKTALVDGTVNVAFGADQTAKTAAVQAYVNGLLSGNAAGVTATVTYNSGTGKYDVALSKGSVNDSKSLSMTVNVAPDPDIAIVAAAKTAAESASYANMTQAAAPNESTIKTALKSTAETAVSNGSVAVTINQISYIAPIAGTSANPSGTNGSYTFTITVSKGSQSETTAQKTIIITATPYTGGTGGGGGNGGGSGSGSNTPAPSTKPTEPVTGNTENKATVDGKGNANVSLTDKNITDAIADAKAEAAKKGVNAGDITAVIHVTTGGKDANTVTVNLPKTTQEQVIDNKISSVQLVIDRPDLTIGINLAAVTEINRQAKADVQLSATRMDNAKLSGDAKAAIGNRPAFDLKATYGSGKSVTDFGKGSVSVEIPYTLQKGEIAGNVYAVYVDAKGKVTYLTDSSYDARRGTVVFSTSHFSTYGIAYKASFNFTDINGHWAKDDILFVANRGLMTGTSATTFNPNGSMTRGMFVTALGRLADADVSGYTKSSFTDVKANAYYMGYIEWGVKNNILVGIGGGKFDPDGLVTREQMAVIMDRYATAIGFKLPEVHAQNTFADNAKIGAWAAPSVKRIQMAGIIQGKSNNLYDPQGTATRAEVSAVLKRFVELAIFNDTAQGWSMNDSGQWMYYENGKPIIGKKDIGGTTYTFDQYGVTADVPKDRAYSTYTVQRGDSFWTIARKFNCTMAELERLNNKSRFSIIFPGDVLRVPKK
>NC_014376.1|WP_013274088.1|3770097_3770592_-|RNA-polymerase-sigma24-factor
MKNYKDSDYALNKFSEGIVYRFADRIVEITLEDYLAENPGKTAQDFLELKALSDEIYHEQVIHENRTSRLDVTINGLEETEQLAAPPLDLDLIHKSDTTKAKEAARRLLDSGELTEIQRRRFILHFVEGLSYRQIASREGVHFTSVHESIEAAATKLQKFFKKI
>NC_014376.1|WP_081443100.1|3767315_3769346_-|ATP-dependent-DNA-helicase
MLSQAVSEPESTFSIKPAIRARNLLEHIFSNILPEHGMDFRENQATLALEMLESLQENRLALCEAEVGTGKTHAYILAVTVHNLFSNNKLPTIISTSTIALQKALTEEYIPQISDILMEHRIIDKPLSFVVRKGKSHYACDSRVKGYRSSIAHNDRHEDKELLSVLTGLFTGACPLDLDTLPLTDYVKSCINVERCHLNCPLSSVCRYRDFIRKAQSLGYDFQIANHNLVLADVLGRKNGRRSLFPPRGVVIFDEAHKLLDAARQMYGMTLENVELERLVASIYHAIGGGNPDKAEIVRLCGTIQEQNVLLFEALRYAAGTGYDKNCYAVQINLNCIRALKTLMAVLRRLSVLFYTTSREKRERYDRLVNRMEQQEVKLSILFHHAGSILWLEMTGATACRVCALPKQLDYLLSEDIWQEEIPYILTSGTISVGGDFSHFKRNNGIILAEKRRIFETSKASPFDYPNHALLYLPQDMPLPSDKDSSYFQAVVNRLVEMIEATHGHTLILFTSYRMMEQVYDELCGRITSFPLFRMGKSRLDAIDAFRKSGKGVLCASDSAGEGIDLAGDILSSLIVVRLPFPAPDPVLEYEKTLYPDFYGYLNKVIVPGMLIKLRQWFGRGIRRETDTCVFSILDSRASRRYRNDILAALPDMPVTHQLSDVNRFIAAKKSGTYFE
>NC_014376.1|WP_013274097.1|3789095_3789275_-|hypothetical-protein
MTYACEDCGFLFYRAGEVKECPSCEKPHIRSATEEEIGRLEKLLEQGKTSLEIKEGQTL
>NC_014376.1|WP_013274098.1|3789312_3790221_-|DUF4428-domain-containing-protein
MGLFSKKPPCPICGGKIPLILPSKIEGEYICNNCYNKIDMDADKESNLTMQGFREYLAFYDQNQILKGQFVVSERIDFGLWDTKIIFDYQNKLFCMSKNPDKTVFEGRQLKSFTIREDSTPLFEGSAAGIRRYTSTVTERAMAMAPQIAQIAASKRMARTLDRLDDGKVNNSTPVQYFDIPEPFQAFHVELHFDHSYWTVLKCDMDGPRFNNTLPDVNNYLRSYQQSIEEIEKLVAALRMVAFPDAAEQSIGPGMVGMGVLQTNMAPPADAIEEIKKYKALMEDGVISQQEFEAKKKQLLGI
>NC_014376.1|WP_013274099.1|3790245_3791931_-|DUF2207-domain-containing-protein
MRKKVSGLILCFALLFALPFPAFAANQVNTMDIQAVIYEDGSMYVTQVWEGNFNEGTESYIPMNAPDYLTISQLTVSDQNGAYETVPDWNIDWSFEEKARKCGIHDTDSGYEICFGISRYGQNRYAIEYKLGNAVGGYSDRDGVNFQFVNDGMNTIPTDVKVEIRLADGTPITEENAAVWGFGYDGQVEFSDGAILAYTESPIAPENHVAVLFSLEKGILYPSRQEQGSFEEVKETAFSGSDYDDTGEEVSTFEAIVTMLLSMGLPIGLMIWSFRIKKKRAEKKRQRFAERFGYFRDIPNDGNLSATYALGRMFDVCEDGAILSTGMLRLIQLGCLSPVETQQIGLMGQTRETVSLRLVGSNHSSMNEYDEYLYTVLESAAGSDSTLQAKELERFVSQNDKLLRTYIQKCDSAGRTYLNQKHCLKRWNTPVKLTDLTPAGEQELGELMGLKRYLTDFSLIAERGVKEMPIWRELLTYAMLFGIADQVAEQMKELYPQISAELTDYSQSMATAYSYHYLLYSSMKNTEEQREQEKRSGGGGGFASLGGGCGSIGGGSGGGTR
>NC_014376.1|WP_013274100.1|3791939_3792494_-|LemA-family-protein
MLPTFITIAVIAAVIVLWIISTQRRLVVLDENISNAMSQIGVQLSSRFDALTALLDLTKGYAKHESETLIETIKSRRSVITAKSTPDDVMRQEGVISEALGRIAMVTEQYPDLKANQSYIKTMDAVQTFENMVRTSRLIYNDSVTKLNREIRMFPVSMVAGMLGFGQREYLVEQADKADMPSMK
>NC_014376.1|WP_013274101.1|3792596_3793019_-|acid-shock-protein
MKKLLVLMMALAMTLSLAACGGNAEPPASTPESTPAAAERKDNVTPEQATAIVDIMAKMGPLYEEAAAAATANGWDQDELAVQELNAVYAIMDSARVGLGELDGYGDTSTEDIDAVIEQYQAMLDEMPNLVTKYSEPYSN
>NC_014376.1|WP_013274102.1|3793069_3793474_-|hypothetical-protein
MKRLLVLIMALAMTLSLAACGGNNAAPAESPSTPTQVEKTEFTAEQQALAQDFMSMAEEFDAIADRVNASPELLENEELVTAMNDLSSEIIKADEYFASPETLTPEIMGALTVAIEVGRSFIAEAGAALEEIGH
>NC_014376.1|WP_013274103.1|3793646_3795650_-|SH3-type-3-domain-containing-protein
MKKQFMGILLTLCMALTLLPTTAFAAEAVTILSYPAKTEYTVGEGFDRTGIKAVVTIGGEKKDISDEISFRNSGNVTLNQGTVFAYIAGKQEITLRWTAPGEKTSQIVGKYTVTVTGEYVAPEKTAPAPTETTHKLYDAIDNGWYSIRLGSIASGAAGLWYGAGDDTFINIDAAGNAVLRTGGRDTKFYVEKKRIVDANTAEITIKMADGRYLGVAGEIDDRAMYKVGTNPVYRSKPDGDIVGELPTGTILEVTELKGDWAKVNYEGKAYYMWAARLTKVSAGETQVAAVDKPYLWQIEIKDSAVAANVVMRPSENPKMMVFTPEKSYKDGARVTLTQLVANVSNVRFEDWGVPVSNTEMAQLFSGVFNNLSKYYPEESPVKWTNERITTHGQAAIDQCYGWRVFTNPNMNWSTNPTYGEFTSYLIKLMDYNKGQVSRKVAPFTKDTIRSFAIGGDTSANAKITWEQAATLQYKTIWWEEKENVRLGEVSGVRDKVEILRLAVPPRNLKSSGGTPGQTPAPAPTPINTVTATPTNTKFMLNGAEAALPAYSIGGNNYVKLRDVGALLKTRFEVRWEDGKAKLYNHAAYTKTSGELTAIGKDGKSATLSTTGFVWGDTGAAVTGLTAYTIGGNNYIKLRDIAKLFDFDVDWRDSKAWIEPDVSPYTED
>NC_014376.1|WP_013274104.1|3795948_3796239_+|helix-turn-helix-transcriptional-regulator
MGVSYNKLFKLMIDKKIRKGELCRAAGISSGSLLKISKDENIYVDILVRICGVLGCDFGDIMEYVPDENSVIKSEPGNRQRPDLQEGEPARVSEEV
>NC_014376.1|WP_013274105.1|3796259_3796988_+|response-regulator-transcription-factor
MLQIAVCDDNIDELSNMVQLIDLYRTSRHLNCEHAVFPNGFELISALEKGKRFDIYCLDIMMPGFTGIDAAKEIRTFDKTAPILFFTSSPEFALESYSVKAINYVLKPISKEKLFFTFDELLEQIKMEKDEDAVIIKSNEGIQKILISNLIFTEVIGRNVLYHLRSGKVIECTEAFSPVCDNLMKYGCFMKPHRSYLVNMQYVDTIENHQITLQTLSSVPIAQGKAKEMKQQYLNYQMEGGA
>NC_014376.1|WP_013274106.1|3796989_3798261_+|sensor-histidine-kinase
MAVTVIGLLRFGVSLIFGITVSVLFAGIELTKKNRLVTGLLCVIFLFVQTASWWLLGLDLTSKLYPLIIHLPLIVIFSLYYKRPWLISVVSVLSGYLCCQAPRWFGFLAGAALDSRLADHIFYIASVFLAYYFLKRYVAGSVRQLMEKSTKSCLFLGGVPLFYYLFDYVTAIYTDVLYSGTEWAVQFMPSTISVFYFVFVILYYAETQKQASLQREKDMLDAQFRLAQTEFASLRQLQQNAASYRHDMRHHFAFLQGLASKEHIEGIKEYLRTAQSDMDAITPTRFCENETVNLILSAFATKAKQGSILLTVDAKLPNELPFSDTELCSLLSNAMENAIHACEQIPDSNKRIIRLRMYSKNNKLCIDLHNSYQIEPIFHQGLPISQEQGHGFGTKSIAHIVEKHGGVFQFSVKDGWFIFQATA

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Crispr_ID: NC_014376_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014376_8

3805505-3805773

Orphan

Consensus_repeat	Method
CCCGCCACGCCGCCGACATA	PILER-CR

3 spacers

The CRISPR arrays of NC_014376_8

>merge|NC_014376|8|3805505-3805773|PILER-CR
CCCGCTACGCCGCCGACATATTGACCGGTGCCGGTGACACTGCCGGTGTTGTAGCAGCTTTGTACCGTACTGCCGTAAACCCGTCCCGCCACGCCGCCGACATTGCTTGTGCCGCTGACGCTGCCGGTGTTGTAGCAGTTTTTCATGGTGCTGCTACCGCTAATCTGCCCCGCCACGCCGCCGACATACTCAGAGCCGCTTACATTTCCGGTGACATAGCAGTTTTCCGCCGTGCTGCTATCAACATACCCCGCCACGCCGCCGACATA

>NC_014376|8|1|3805505-3805773|PILER-CR
CCCGCTACGCCGCCGACATA	TTGACCGGTGCCGGTGACACTGCCGGTGTTGTAGCAGCTTTGTACCGTACTGCCGTAAACCCGT
CCCGCCACGCCGCCGACATT	GCTTGTGCCGCTGACGCTGCCGGTGTTGTAGCAGTTTTTCATGGTGCTGCTACCGCTAATCTGC
CCCGCCACGCCGCCGACATA	CTCAGAGCCGCTTACATTTCCGGTGACATAGCAGTTTTCCGCCGTGCTGCTATCAACATAC
CCCGCCACGCCGCCGACATA

Protein	Signature genes	Signature genes Name	Protein_function
NC_014376.1\|WP_013274112.1\|3808783_3810970_+\|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	gnl\|CDD\|370278
NC_014376.1\|WP_013274114.1\|3813558_3820563_-\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|212030
NC_014376.1\|WP_013274110.1\|3807468_3807849_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|333815
NC_014376.1\|WP_013274115.1\|3820792_3821422_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_014376.1\|WP_013274101.1\|3792596_3793019_-\|acid-shock-protein	unknown	unknown	unknown
NC_014376.1\|WP_013274103.1\|3793646_3795650_-\|SH3-type-3-domain-containing-protein	unknown	unknown	unknown
NC_014376.1\|WP_013274100.1\|3791939_3792494_-\|LemA-family-protein	unknown	unknown	gnl\|CDD\|224618
NC_014376.1\|WP_013274120.1\|3825829_3826525_-\|hypothetical-protein	unknown	unknown	unknown
NC_014376.1\|WP_013274118.1\|3823174_3823999_-\|C39-family-peptidase	unknown	unknown	gnl\|CDD\|379241
NC_014376.1\|WP_013274119.1\|3823998_3825837_-\|DUF87-domain-containing-protein	unknown	unknown	gnl\|CDD\|274279
NC_014376.1\|WP_013274107.1\|3798538_3799033_-\|RNA-polymerase-sigma24-factor	unknown	unknown	gnl\|CDD\|224511
NC_014376.1\|WP_013274105.1\|3796259_3796988_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225818
NC_014376.1\|WP_013274104.1\|3795948_3796239_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379188
NC_014376.1\|WP_013274117.1\|3822155_3823160_-\|hypothetical-protein	unknown	unknown	unknown
NC_014376.1\|WP_013274106.1\|3796989_3798261_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|340412
NC_014376.1\|WP_013274102.1\|3793069_3793474_-\|hypothetical-protein	unknown	unknown	unknown
NC_014376.1\|WP_013274098.1\|3789312_3790221_-\|DUF4428-domain-containing-protein	unknown	unknown	gnl\|CDD\|373083
NC_014376.1\|WP_013274111.1\|3808061_3808787_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225818
NC_014376.1\|WP_013274099.1\|3790245_3791931_-\|DUF2207-domain-containing-protein	unknown	unknown	gnl\|CDD\|378333
NC_014376.1\|WP_013274113.1\|3810962_3812897_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|340412

Protein	Function_ID	Function_description	E-value
NC_014376.1\|WP_013274114.1\|3813558_3820563_-\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|212030	cd00118, LysM, Lysin Motif is a small domain involved in binding peptidoglycan. LysM, a small globular domain with approximately 40 amino acids, is a widespread protein module involved in binding peptidoglycan in bacteria and chitin in eukaryotes. The domain was originally identified in enzymes that degrade bacterial cell walls, but proteins involved in many other biological functions also contain this domain. It has been reported that the LysM domain functions as a signal for specific plant-bacteria recognition in bacterial pathogenesis. Many of these enzymes are modular and are composed of catalytic units linked to one or several repeats of LysM domains. LysM domains are found in bacteria and eukaryotes.	5.71542e-10
NC_014376.1\|WP_013274110.1\|3807468_3807849_-\|hypothetical-protein	gnl\|CDD\|333815	pfam00072, Response_reg, Response regulator receiver domain. This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.	8.46848e-05
NC_014376.1\|WP_013274115.1\|3820792_3821422_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.20285e-12
NC_014376.1\|WP_013274100.1\|3791939_3792494_-\|LemA-family-protein	gnl\|CDD\|224618	COG1704, LemA, Uncharacterized conserved protein [Function unknown].	2.76923e-43
NC_014376.1\|WP_013274099.1\|3790245_3791931_-\|DUF2207-domain-containing-protein	gnl\|CDD\|378333	pfam09972, DUF2207, Predicted membrane protein (DUF2207). This domain, found in various hypothetical bacterial proteins, has no known function.	9.31697e-14
NC_014376.1\|WP_013274118.1\|3823174_3823999_-\|C39-family-peptidase	gnl\|CDD\|379241	pfam13529, Peptidase_C39_2, Peptidase_C39 like family.	3.37512e-18
NC_014376.1\|WP_013274119.1\|3823998_3825837_-\|DUF87-domain-containing-protein	gnl\|CDD\|274279	TIGR02746, hypothetical_protein, type-IV secretion system protein TraC. The protein family described here is common among the F, P and I-like type IV secretion systems. Gene symbols include TraC (F-type), TrbE/VirB4 (P-type) and TraU (I-type). The protein conyains the Walker A and B motifs and so is a putative nucleotide triphosphatase.	3.20389e-18
NC_014376.1\|WP_013274107.1\|3798538_3799033_-\|RNA-polymerase-sigma24-factor	gnl\|CDD\|224511	COG1595, RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription].	0.000729254
NC_014376.1\|WP_013274105.1\|3796259_3796988_+\|response-regulator-transcription-factor	gnl\|CDD\|225818	COG3279, LytT, Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms].	9.78502e-26
NC_014376.1\|WP_013274104.1\|3795948_3796239_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|379188	pfam13443, HTH_26, Cro/C1-type HTH DNA-binding domain. This is a helix-turn-helix domain that probably binds to DNA.	1.20555e-18
NC_014376.1\|WP_013274106.1\|3796989_3798261_+\|sensor-histidine-kinase	gnl\|CDD\|340412	cd16935, HATPase_AgrC-ComD-like, Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing. This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.	1.14607e-30
NC_014376.1\|WP_013274112.1\|3808783_3810970_+\|LPXTG-cell-wall-anchor-domain-containing-protein	gnl\|CDD\|370278	pfam09073, BUD22, BUD22. BUD22 has been shown in yeast to be a nuclear protein involved in bud-site selection. It plays a role in positioning the proximal bud pole signal. More recently it has been shown to be involved in ribosome biogenesis.	6.78528e-05
NC_014376.1\|WP_013274111.1\|3808061_3808787_+\|response-regulator-transcription-factor	gnl\|CDD\|225818	COG3279, LytT, Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms].	3.75822e-22
NC_014376.1\|WP_013274098.1\|3789312_3790221_-\|DUF4428-domain-containing-protein	gnl\|CDD\|373083	pfam14471, DUF4428, Domain of unknown function (DUF4428). This putative zinc finger domain is found in uncharacterized bacterial proteins.	2.22716e-08
NC_014376.1\|WP_013274113.1\|3810962_3812897_+\|sensor-histidine-kinase	gnl\|CDD\|340412	cd16935, HATPase_AgrC-ComD-like, Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing. This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.	9.48229e-35

>NC_014376.1|WP_013274107.1|3798538_3799033_-|RNA-polymerase-sigma24-factor
MKNYKESDYALNKFSEGIVYRFADRIVEITLEDYLAENPGKTAEDFMELKALSDEIYHQQVIDENRTSRLDVSINGLEDTEALATASLDVELIHKKDTEKAIEAARQLLDSGGLTEVQRRRFLLHFFQGLSYRQIASCEGVHFTSVHESIKAATAKLQRFFDIG
>NC_014376.1|WP_013274106.1|3796989_3798261_+|sensor-histidine-kinase
MAVTVIGLLRFGVSLIFGITVSVLFAGIELTKKNRLVTGLLCVIFLFVQTASWWLLGLDLTSKLYPLIIHLPLIVIFSLYYKRPWLISVVSVLSGYLCCQAPRWFGFLAGAALDSRLADHIFYIASVFLAYYFLKRYVAGSVRQLMEKSTKSCLFLGGVPLFYYLFDYVTAIYTDVLYSGTEWAVQFMPSTISVFYFVFVILYYAETQKQASLQREKDMLDAQFRLAQTEFASLRQLQQNAASYRHDMRHHFAFLQGLASKEHIEGIKEYLRTAQSDMDAITPTRFCENETVNLILSAFATKAKQGSILLTVDAKLPNELPFSDTELCSLLSNAMENAIHACEQIPDSNKRIIRLRMYSKNNKLCIDLHNSYQIEPIFHQGLPISQEQGHGFGTKSIAHIVEKHGGVFQFSVKDGWFIFQATA
>NC_014376.1|WP_013274105.1|3796259_3796988_+|response-regulator-transcription-factor
MLQIAVCDDNIDELSNMVQLIDLYRTSRHLNCEHAVFPNGFELISALEKGKRFDIYCLDIMMPGFTGIDAAKEIRTFDKTAPILFFTSSPEFALESYSVKAINYVLKPISKEKLFFTFDELLEQIKMEKDEDAVIIKSNEGIQKILISNLIFTEVIGRNVLYHLRSGKVIECTEAFSPVCDNLMKYGCFMKPHRSYLVNMQYVDTIENHQITLQTLSSVPIAQGKAKEMKQQYLNYQMEGGA
>NC_014376.1|WP_013274104.1|3795948_3796239_+|helix-turn-helix-transcriptional-regulator
MGVSYNKLFKLMIDKKIRKGELCRAAGISSGSLLKISKDENIYVDILVRICGVLGCDFGDIMEYVPDENSVIKSEPGNRQRPDLQEGEPARVSEEV
>NC_014376.1|WP_013274103.1|3793646_3795650_-|SH3-type-3-domain-containing-protein
MKKQFMGILLTLCMALTLLPTTAFAAEAVTILSYPAKTEYTVGEGFDRTGIKAVVTIGGEKKDISDEISFRNSGNVTLNQGTVFAYIAGKQEITLRWTAPGEKTSQIVGKYTVTVTGEYVAPEKTAPAPTETTHKLYDAIDNGWYSIRLGSIASGAAGLWYGAGDDTFINIDAAGNAVLRTGGRDTKFYVEKKRIVDANTAEITIKMADGRYLGVAGEIDDRAMYKVGTNPVYRSKPDGDIVGELPTGTILEVTELKGDWAKVNYEGKAYYMWAARLTKVSAGETQVAAVDKPYLWQIEIKDSAVAANVVMRPSENPKMMVFTPEKSYKDGARVTLTQLVANVSNVRFEDWGVPVSNTEMAQLFSGVFNNLSKYYPEESPVKWTNERITTHGQAAIDQCYGWRVFTNPNMNWSTNPTYGEFTSYLIKLMDYNKGQVSRKVAPFTKDTIRSFAIGGDTSANAKITWEQAATLQYKTIWWEEKENVRLGEVSGVRDKVEILRLAVPPRNLKSSGGTPGQTPAPAPTPINTVTATPTNTKFMLNGAEAALPAYSIGGNNYVKLRDVGALLKTRFEVRWEDGKAKLYNHAAYTKTSGELTAIGKDGKSATLSTTGFVWGDTGAAVTGLTAYTIGGNNYIKLRDIAKLFDFDVDWRDSKAWIEPDVSPYTED
>NC_014376.1|WP_013274102.1|3793069_3793474_-|hypothetical-protein
MKRLLVLIMALAMTLSLAACGGNNAAPAESPSTPTQVEKTEFTAEQQALAQDFMSMAEEFDAIADRVNASPELLENEELVTAMNDLSSEIIKADEYFASPETLTPEIMGALTVAIEVGRSFIAEAGAALEEIGH
>NC_014376.1|WP_013274101.1|3792596_3793019_-|acid-shock-protein
MKKLLVLMMALAMTLSLAACGGNAEPPASTPESTPAAAERKDNVTPEQATAIVDIMAKMGPLYEEAAAAATANGWDQDELAVQELNAVYAIMDSARVGLGELDGYGDTSTEDIDAVIEQYQAMLDEMPNLVTKYSEPYSN
>NC_014376.1|WP_013274100.1|3791939_3792494_-|LemA-family-protein
MLPTFITIAVIAAVIVLWIISTQRRLVVLDENISNAMSQIGVQLSSRFDALTALLDLTKGYAKHESETLIETIKSRRSVITAKSTPDDVMRQEGVISEALGRIAMVTEQYPDLKANQSYIKTMDAVQTFENMVRTSRLIYNDSVTKLNREIRMFPVSMVAGMLGFGQREYLVEQADKADMPSMK
>NC_014376.1|WP_013274099.1|3790245_3791931_-|DUF2207-domain-containing-protein
MRKKVSGLILCFALLFALPFPAFAANQVNTMDIQAVIYEDGSMYVTQVWEGNFNEGTESYIPMNAPDYLTISQLTVSDQNGAYETVPDWNIDWSFEEKARKCGIHDTDSGYEICFGISRYGQNRYAIEYKLGNAVGGYSDRDGVNFQFVNDGMNTIPTDVKVEIRLADGTPITEENAAVWGFGYDGQVEFSDGAILAYTESPIAPENHVAVLFSLEKGILYPSRQEQGSFEEVKETAFSGSDYDDTGEEVSTFEAIVTMLLSMGLPIGLMIWSFRIKKKRAEKKRQRFAERFGYFRDIPNDGNLSATYALGRMFDVCEDGAILSTGMLRLIQLGCLSPVETQQIGLMGQTRETVSLRLVGSNHSSMNEYDEYLYTVLESAAGSDSTLQAKELERFVSQNDKLLRTYIQKCDSAGRTYLNQKHCLKRWNTPVKLTDLTPAGEQELGELMGLKRYLTDFSLIAERGVKEMPIWRELLTYAMLFGIADQVAEQMKELYPQISAELTDYSQSMATAYSYHYLLYSSMKNTEEQREQEKRSGGGGGFASLGGGCGSIGGGSGGGTR
>NC_014376.1|WP_013274098.1|3789312_3790221_-|DUF4428-domain-containing-protein
MGLFSKKPPCPICGGKIPLILPSKIEGEYICNNCYNKIDMDADKESNLTMQGFREYLAFYDQNQILKGQFVVSERIDFGLWDTKIIFDYQNKLFCMSKNPDKTVFEGRQLKSFTIREDSTPLFEGSAAGIRRYTSTVTERAMAMAPQIAQIAASKRMARTLDRLDDGKVNNSTPVQYFDIPEPFQAFHVELHFDHSYWTVLKCDMDGPRFNNTLPDVNNYLRSYQQSIEEIEKLVAALRMVAFPDAAEQSIGPGMVGMGVLQTNMAPPADAIEEIKKYKALMEDGVISQQEFEAKKKQLLGI
>NC_014376.1|WP_013274110.1|3807468_3807849_-|hypothetical-protein
MNVALCAAFLEEDVWENRLVTAALPQRIEITECNSAGALLKILELKPFSLLIVVLNGVAGLEAVRRLREKAPDVPLLWISDEDYSLFGYQYRVTCFLRRTVSEVQLREAVAGCLKISGNGEEETAK
>NC_014376.1|WP_013274111.1|3808061_3808787_+|response-regulator-transcription-factor
MNAAIVDDMATECEILRSLLKQYETNQHQPMQITEFHSGREFLADYIPGSYDVVFMDIYLNNENGVDCALKLRQLDENLNLIFLTTSSEFGVKSYDVRAADYIVKPATLDKLSRALHYCKIAEPQSVPSVTVTTRNQLLEITLDRILYADYQNRCACIHLKDCLVPVSGSFSELSEQLCTYPQFMSCFKGIVINLKEVRELEADYLILKNEEQLPVSRRLQKQVQQKRLSLSAGSLRGEGI
>NC_014376.1|WP_013274112.1|3808783_3810970_+|LPXTG-cell-wall-anchor-domain-containing-protein
MKQILALILTAFLFCTALASPVLAVEGPIIPAETTDTSTDSGGGTVSDDSIDTSTPSDAGMITDDEETSDTDNSTVGADGTDDSSVPGSFDYTSNIISYTAPDAFTGTFNTDCGDTDFTQLQNELDFISIPATAQKDGSSYPLTLSVTWDFSTVDAETPGTYTVIGNISVPARTTLLEGLENTVSISVQVTAPLLTVTPAAITLTSFDEPDRTDAVAFPVGTTQEELSNWFADSIAGFIGYDAEGNPYDLISGAWSLDTVDTVTAGVYYAFTSPDLGTEYTLADGVSLPRQLCAVSIQVPGEPDINCCVAGRGFLHFPWVLSAAQEEQLVEFAVWLRQDGGEWTSLNDGFLSVSDGLHLSQRVLTYGSTYELKVTYPGGQTGVLTFQYDGELSILDYSGGDRDGGDVNGGGSGTGTQPAPPPTNPPDNSNEDNNSGNDNDSPDTSDSSSDTDEPSQDSGSSSVEQQKPQGGQNSSTDEDEPSPSAPQSPSDSQSNDSHNSEGNSQAQVPVTEKSAAVTPATPTESAVPVFSDTQTVGNPVPDDNTTQSEKSLESQVSATVTESYSPTQTVISGLRLKDLCKEEESVVFGSGDVTVSIPSKLLLALNLSDTDTLTVRLTQLESNQIVLAVEVSGKPVTQLSGTVLRLRYMPQSKHTDITIQNEAGEQITDVSYDGELLRFAADAAGTYTITDLSTTQETGKSTSPLIPVSGGLLLAAGGITLFRRKRHG
>NC_014376.1|WP_013274113.1|3810962_3812897_+|sensor-histidine-kinase
MDKKPFVLRRSLALLLMVALSSALFLALYHFDNKYTKAAPQAINGALYVSEADWTDIPIRYLRDGWRFYADRLLTPETLKQQGDNYQYLSIGEKSNFAMGDSRRSPHGSASYALTLYLPEEEHTYALELPEIYSAYRFYIDDKLKLQMGEPDPDDYQDQTQCRVITFEASGKVTLLLAVSDHSFLYSGLVYPPSFGEPLNTYTIRGLRFGICLILVTVTLMLAIFSFYLAIRTRRGNNIWIFFLLCLSTAVFTSYCVVHGILPLPIQPWYTVELVSGYLVTLLVIILHNRICGTNRTMQVISGATSGVVCVLVLLYGVFAAHLTLPVMLAFSNLVFGFKLLTAVYLLFTAAMAVRRTIEKATILLYADIIYACAFVWDRLLPNYEPILSGWFQEWGSLSLVIATGVVLGYDITMGYRHSLVYAEEQRQMKRQLTMQVEHLRQMNQKVEESAKLRHDFRHHLRTLMTLAGEGHCEELENYIRGITEINEGTRLGRLTDNIELDALVQYYSNLAQSAGIQFRARLSLPAVLNFPIVDLCGLLGNLMENAVEACQRQQTGDKTIFIAGRVQDGQLEFVVDNSFAGELKTRGGKYLSSKRSGFGLGVSSVLETVERYNGVINLYADEKGFHAELSLSTGVEKRIPSPV
>NC_014376.1|WP_013274114.1|3813558_3820563_-|LysM-peptidoglycan-binding-domain-containing-protein
MSKRKPIQRLTAMVLSVIMVMGMSPVSALAETGAFPIGASGEVTAFEALESDIAVQNVPIGTSQADLELPNTLTATVRLAASGEEPVLDSGDADSDSGSADTVSGSAIGIDNMEDSESGEEAEIASPSDAEETGGNMEAEPVEKPVGSTGILTAPMPVTWTSSPEYDSETAGEYIFTPELPEGITTASGVKAPTITVTVGTAAITDTVTAFDDLPDEIRWQNTTEPEFPKTLDGTVDGKAAQISVKWETEQEFDEEYPVRGIYVFTAVLGKGYGLADGVELPHITVYIPQTVGGRMSRMAGGGTTDSPLEITTAAQLAEIAALVNSRSSGLELFLFNDAGAKVSLKMTNDIDLSAYSTGEGWVPIGTATNHFKGTFDGGGHQITGLYINRSAVYQGLFGWVESGGTVKDLGVTNVNISGGVGVGGVAAVAEGAVENCYVSGSLRGGANIGGVAGWVRDTMETCYFSGSVEGSSPAGGVASVVSGVMRNCYSTGSVTVDYVTVGGVTGLVFGGRMENCYSTCKVSVTINYGTAGGVAGSVSDGTVQNCAALNPSVSGTSNAGRVAGSVFSGTLTNNYAYTGMTCTSVGTTHNDGTALTAADIGSAGFFEALFGDDPAWTYEKGKLPGFGAAVDMPGHIVDGSDPNFRGAGTSGNPFQIYTPADLAKLAELVNAGNASYTTAHYKLMNDLDLSGYAAGEGWTPIGKSAYAQAFKGIFDGGGHTISNLTINRVGGEYQGLFGHLSNVGSVRAVVKNLGVENADVLAKKYVGGVAGYVFGSTVQNCYSTGSIRGTASTSYDVGGVAGRVNSGTVENCYSIGSISGTNNIGGVAGAVVGSGTVQHCYSTATVSASAYSGGGVAGYLVNSTVKNCYSTGNVSGNNDIGGVAGSITTSSTLKDCAALNPSGSGSSNVGRVVGSNSGSTPSGNIAFDGMTVNGSTVSDGTLINTNGASKTADEINAAGFWTIATDFTADWDTSIWDKEPGKLPILKGMAGQDASMPAHLRPAGASPFEGAGTSEGDPYLIKTAADLAKLAELVNAGISPYADAGRYYKLVNNLDLSDYGAGYDGGKGWIPIGTDTKPFNGVLNGGDHQITGLYIKRSAHYQGLFGCINIGSVKNLGVANVNISGIFSGGGLAGLIYGTVQNCYVSGSVSGVSNIGGMAGWIYGTMQSCYVSGNVSATNPAAAVGGVASVVRKGGTMQNCYSTGSVSVSSVEHYNYIGGVVGIVSGTVQNCYSTSNVSSTKNADSIGGVMGTLLEGTLQNCAALNPSVSSSSYSGRVVGNCFAPYFLYNNYAFSRIPGTWANEGLNAKDGMDVTSDTLFGGSFWTTASNWNTAAWDSNVWTFEDGKLPTLKGLAGQNGDGGLYMSARDIQYATVGTSAPLTYNGSEQIPTLTVTFDGETLTKNTDYTVSITSTDGGGASAGINAGEVTLTLTGIGSFKGIKTATYTIGKAPLTIVSASINPKFYDSTITAEVANVSFDGLQPTETLAISVDYTVTGARYNSADAGDNKTVTATVTLANSATAKNYSLLSDVLSISGMTIGKADFSSVDPVNKSLLYSAAHTNATVNITGLPDDRGTTTFTAGTVTGDTAIISGTVQGTATGIKFSTNAGDIGQTAIIPVTATMQNYKDVVVDVVVTLVNKTPVTITGVMVANKVYDGTAIAYTGTPANGQGYIGTYQYVWSSGSAPKDAGNYTLTVKIPDSNADFMGEIEIPFIISPATVTITAKDKIAYVGGTAPALGESDYTVTGLASGETLNTTPTLAYTTTPDMSKTGTYTIIATDAVAPDSSNYNSTITYITGTLTIRNRPSGGGNSSDSSPIIITPPAADKPNSPTQGEIKVTGTGDGKGNITVNITNKIVTDAFDKALAEAKKNGNEQNGITVVLRVDTGSKTGSNVTVNLPKAVQNTIIAKKIVNIIIVVDNPDIRIGIDLAAVQEINKQAKSDVNITAIRMDSGKLTGDAKKAIGSRPVFDFKVNYGSGKQVQSFGAGNVLVTIPYTLGANEKAGNVQAVYVDAKGKVHWVVNSVYDSVEQVLRFSTDHFSTYGIGYKQTNTTFTDIAGHWAKEDIEFVASRGLFSGTSTTTFSPNTAMTRGMFVTALGRLANADVSGYTKSSFTDVKGDAYYMGYIEWASKNNIVNGVGNGRFAPDQSITREQMAVIMQNYAKVIGFTLPKVHVENTFADSTKINTYAKEAVKQMQMAGVISGKNSNLFDPQGTATRAEVSAVLRRFVELAISSDTMQGWTMNDSGKWMYYENGKAVTGKKEIDGSAYTFDQYGVTSDVPKNLRYTAYTIQKGDSFWSIARKLNCTMDELERLNNKSQFSIIHPGDVLRVPEK
>NC_014376.1|WP_013274115.1|3820792_3821422_+|TetR/AcrR-family-transcriptional-regulator
MREKKPDKRKVQGAETKKKLYEIAERLFTERNFSDVNVEDITDEAGITKGAFYVHFESKDALIAILVADHAAKTDADYKTFLESLPDDMPASLVLFALAERIADTLANTFGCKNMTKIYQMLLSGTAGTEAVKGYGRELYALVYSILEKGLRSGEFTSSLPLETLSRHFVMAIRGVSYEWCVRYPHFDLKEQAIEHTRLLIEGMKASCS
>NC_014376.1|WP_013274117.1|3822155_3823160_-|hypothetical-protein
MILYLSSTQHTNLLDFTGLYNADSEMPIKKMVGNFVLKQFIVYDMRNFSHVTEVVLDRVAFGDSDEEFAEAIEEFLTMYNPRISVICEGLLQDNPLFRSLLESGVGNIVCSTDIAEIQLEILECLSKQGMVRYAAKERTKKTGGRKTYRFDCENVHIAVLSSQPRMGATTTAIGLCAWLAAVGASVCYVEENESGILTAMAAAYEMEPAGEDWRLDGVRYGMEPAAEPVNFIVHDFGCQPNPNEKANDAGLLLIVCGTKPYELPNSMRLLKRLDTVDAYVLCPFTHEAVRSDYAAILQSNFHKVLFLEYQPEPTDGMSNSKQYKTMMTKYIAGA
>NC_014376.1|WP_013274118.1|3823174_3823999_-|C39-family-peptidase
MAVDPLTVKILTQIAAQVATDEQARKRLLIIILAPTVTFLMLIALILYLITSPFSVLAQWLIGDELSVVEDFQKEYGYNQTLGIHEQDYMDGIGQSYEGIVFADGGMEVVYYNQLDERWSSTMYGTSGTIGEGGCGPTAMSIIISTLTGEPHDPVELANWSVTNGHRCEGNGSYHSLIPAAAEGYGLSSKGNLSAQDIVDTLSSGKLVVAIMSKGYFTNSGHFIVLRGVTSEGKILVADPASHKRSQQEWDLSLILNEARKGAAAGGPFWAIGN
>NC_014376.1|WP_013274119.1|3823998_3825837_-|DUF87-domain-containing-protein
MPKKQAVQERDIINAALLNVITPMGLEFTKNSLSVGENLGKIYGLIRYPQKVETEWLSKITNIPSTIASIGFKPVDNATLINAISRSVVQQRGLAEGAKDPLSRQRAEKAAEDGEKIIMQIDREGETVGLMSVSVMPISKDERTFKKVCRRAESIISVLKCKMRVIPNLQKECFQHISPSFPTNGKIESILQKIVPLSTFVGGFPFASSGFNDGEGYYLALDASGSLVIVDIWRRGSDRTNSNFVIMGNSGVGKSTAIKHIIMSEYMKGTKIIVIDPESEYKDLCYNLGCGGDWVNAVGGAGGRFNPLQVRPSPRDDEQENEADRLYRDEGYGMNDLALHMKNLEIFFSLYIPSLTDMQKAVLKKSLVELYRNFNITWDTDVAALSPEDFPIFSDLYKLVKEKADTEQDRQAYADLSLLLYDIAEGSDSFIWNGHTTIKSESRFVCLDTNALQGTSDNIKRTQYFNLLTYCWEQMSRNRDERVLLICDEAYLMIDQKVPQSLVYLRNAMKRARKYEAALAIISHSVIDFLSESIRQYGQALLDIPCYKLLMGTDGPNLKETAKLYDLTEAEQELLLARKRGHALFMVGAKRLHINFEIPDYKMMYMGKAGGR
>NC_014376.1|WP_013274120.1|3825829_3826525_-|hypothetical-protein
MEGLLFPIIMLTVTLVGGGLLLLFLKTAKKRPVSDETAIAIQTAQQFINVRDVKDKYLYTKDGLVLVYLRVHAISIDLYSKAEKNNLIKQITAELSDIQYPFKFMAVSRPVDISPLISDMQGMLKTADDKRKELLRQEILQMSSFALSGEIVERQFYISLWDRYEDGVEKDLLKRASLLAEKFTTNGVGCDILTEKEIVRLLNLVNNPSYTHLEDTDFEASIPMLKEDIYA

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Crispr_ID: NC_014376_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014376_9

4257716-4257858

Orphan

Consensus_repeat	Method
AGTGAAGATAAAAGGGCTGTTTTCCAGCCCGTTCATCCGTTTATGAAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014376_9

>merge|NC_014376|9|4257716-4257858|CRISPRCasFinder
AGTGAAGATAAAAGGGCTGTTTTCCAGCCCGTTCATCCGTTTATGAAAGCATTCTTTGTTTTCATCATATAAAACTTATCTTTACTTGCAGCGCTAGTGAAGATAAAAGGGCTGTTTTCCAGCCCATTCATCCGTTTATGAAA

>NC_014376|9|7|4257716-4257858|CRISPRCasFinder
AGTGAAGATAAAAGGGCTGTTTTCCAGCCCGTTCATCCGTTTATGAAA	GCATTCTTTGTTTTCATCATATAAAACTTATCTTTACTTGCAGCGCT
AGTGAAGATAAAAGGGCTGTTTTCCAGCCCATTCATCCGTTTATGAAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_014376.1\|WP_013274497.1\|4261152_4262295_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173847
NC_014376.1\|WP_013274486.1\|4249246_4249486_+\|hypothetical-protein	unknown	unknown	unknown
NC_014376.1\|WP_013274492.1\|4255413_4256421_+\|acetyl-esterase	unknown	unknown	gnl\|CDD\|236660
NC_014376.1\|WP_013274501.1\|4264999_4266214_-\|CoA-transferase	unknown	unknown	gnl\|CDD\|367110
NC_014376.1\|WP_013274489.1\|4253146_4253857_+\|DUF421-domain-containing-protein	unknown	unknown	gnl\|CDD\|225205
NC_014376.1\|WP_013274504.1\|4268583_4269510_+\|electron-transfer-flavoprotein-subunit-alpha	unknown	unknown	gnl\|CDD\|183380
NC_014376.1\|WP_013274503.1\|4267792_4268554_+\|putative-electron-transfer-flavoprotein-FixA	unknown	unknown	gnl\|CDD\|183455
NC_014376.1\|WP_013274500.1\|4264318_4264966_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293792
NC_014376.1\|WP_013274485.1\|4249068_4249218_+\|hypothetical-protein	unknown	unknown	unknown
NC_014376.1\|WP_013274502.1\|4266245_4267430_-\|CoA-transferase	unknown	unknown	gnl\|CDD\|367110
NC_014376.1\|WP_013274493.1\|4256529_4257570_-\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_014376.1\|WP_041709508.1\|4246510_4248700_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|226482
NC_014376.1\|WP_013274495.1\|4259330_4260944_-\|sodium:solute-symporter-family-protein	unknown	unknown	gnl\|CDD\|271357
NC_014376.1\|WP_013274494.1\|4257939_4259226_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|349949
NC_014376.1\|WP_013274488.1\|4251097_4252513_-\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|236722
NC_014376.1\|WP_013274499.1\|4263528_4264302_-\|enoyl-CoA-hydratase	unknown	unknown	gnl\|CDD\|180591
NC_014376.1\|WP_013274490.1\|4253939_4254650_+\|DUF421-domain-containing-protein	unknown	unknown	gnl\|CDD\|225205
NC_014376.1\|WP_013274498.1\|4262330_4263467_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|183454
NC_014376.1\|WP_013274483.1\|4243498_4245994_-\|LuxR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225461
NC_014376.1\|WP_013274487.1\|4249562_4250576_-\|DUF4489-domain-containing-protein	unknown	unknown	gnl\|CDD\|379710

Protein	Function_ID	Function_description	E-value
NC_014376.1\|WP_013274503.1\|4267792_4268554_+\|putative-electron-transfer-flavoprotein-FixA	gnl\|CDD\|183455	PRK12342, PRK12342, electron transfer flavoprotein.	3.69457e-91
NC_014376.1\|WP_013274492.1\|4255413_4256421_+\|acetyl-esterase	gnl\|CDD\|236660	PRK10162, PRK10162, acetyl esterase.	0
NC_014376.1\|WP_013274500.1\|4264318_4264966_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293792	cd06262, metallo-hydrolase-like_MBL-fold, mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases which can catalyze the hydrolysis of a wide range of beta-lactam antibiotics, hydroxyacylglutathione hydrolases (also called glyoxalase II) which hydrolyze S-d-lactoylglutathione to d-lactate in the second step of the glycoxlase system, AHL lactonases which catalyze the hydrolysis and opening of the homoserine lactone rings of acyl homoserine lactones (AHLs), persulfide dioxygenase which catalyze the oxidation of glutathione persulfide to glutathione and persulfite in the mitochondria, flavodiiron proteins which catalyze the reduction of oxygen and/or nitric oxide to water or nitrous oxide respectively, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J which has both 5'-3' exoribonucleolytic and endonucleolytic activity and ribonuclease Z which catalyzes the endonucleolytic removal of the 3' extension of the majority of tRNA precursors, cyclic nucleotide phosphodiesterases which decompose cyclic adenosine and guanosine 3', 5'-monophosphate (cAMP and cGMP) respectively, insecticide hydrolases, and proteins required for natural transformation competence. The diversity of biological roles is reflected in variations in the active site metallo-chemistry, for example classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, human persulfide dioxygenase ETHE1 is a mono-iron binding member of the superfamily; Arabidopsis thaliana hydroxyacylglutathione hydrolases incorporates iron, manganese, and zinc in its dinuclear metal binding site, and flavodiiron proteins contains a diiron site.	2.1951e-62
NC_014376.1\|WP_013274489.1\|4253146_4253857_+\|DUF421-domain-containing-protein	gnl\|CDD\|225205	COG2323, COG2323, Predicted membrane protein [Function unknown].	2.52783e-64
NC_014376.1\|WP_013274504.1\|4268583_4269510_+\|electron-transfer-flavoprotein-subunit-alpha	gnl\|CDD\|183380	PRK11916, PRK11916, electron transfer flavoprotein subunit alpha.	1.21408e-74
NC_014376.1\|WP_013274501.1\|4264999_4266214_-\|CoA-transferase	gnl\|CDD\|367110	pfam02515, CoA_transf_3, CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	6.73682e-120
NC_014376.1\|WP_013274487.1\|4249562_4250576_-\|DUF4489-domain-containing-protein	gnl\|CDD\|379710	pfam14879, DUF4489, Domain of unknown function (DUF4489).	1.72074e-48
NC_014376.1\|WP_013274502.1\|4266245_4267430_-\|CoA-transferase	gnl\|CDD\|367110	pfam02515, CoA_transf_3, CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	2.79449e-98
NC_014376.1\|WP_013274493.1\|4256529_4257570_-\|LacI-family-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	5.78152e-53
NC_014376.1\|WP_041709508.1\|4246510_4248700_-\|AAA-family-ATPase	gnl\|CDD\|226482	COG3973, COG3973, Superfamily I DNA and RNA helicases [General function prediction only].	5.77349e-126
NC_014376.1\|WP_013274495.1\|4259330_4260944_-\|sodium:solute-symporter-family-protein	gnl\|CDD\|271357	cd10322, SLC5sbd, Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain. This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.	2.11643e-57
NC_014376.1\|WP_013274494.1\|4257939_4259226_-\|MFS-transporter	gnl\|CDD\|349949	cd06174, MFS, Major Facilitator Superfamily. The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.	1.27068e-16
NC_014376.1\|WP_013274488.1\|4251097_4252513_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|236722	PRK10590, PRK10590, ATP-dependent RNA helicase RhlE; Provisional.	7.20612e-157
NC_014376.1\|WP_013274499.1\|4263528_4264302_-\|enoyl-CoA-hydratase	gnl\|CDD\|180591	PRK06494, PRK06494, enoyl-CoA hydratase; Provisional.	2.89771e-83
NC_014376.1\|WP_013274490.1\|4253939_4254650_+\|DUF421-domain-containing-protein	gnl\|CDD\|225205	COG2323, COG2323, Predicted membrane protein [Function unknown].	8.54877e-62
NC_014376.1\|WP_013274498.1\|4262330_4263467_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|183454	PRK12341, PRK12341, acyl-CoA dehydrogenase.	1.10373e-141
NC_014376.1\|WP_013274483.1\|4243498_4245994_-\|LuxR-family-transcriptional-regulator	gnl\|CDD\|225461	COG2909, MalT, ATP-dependent transcriptional regulator [Transcription].	1.34711e-20
NC_014376.1\|WP_013274497.1\|4261152_4262295_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	0

>NC_014376.1|WP_013274493.1|4256529_4257570_-|LacI-family-transcriptional-regulator
MQRITIKDIAAEVGVSHTTVSYVLNNNTNQRISDKTREAVLDAARRLKYVPNETARSLRKDSTECIAVALEKSVAQSRFGRLLQGIREVLGTEGYGLMLMDFQMNKESKCPEYVESVLQRRTDGVIFISSDGLPPVCSRMIDSYKIPFVACDCCPEEEGLASVSFDYEDGAFEVACCLLGEGAKRILYWQPGVDSLQEEYRLCGLKKAMELYPDAELIVCKVPVMQGTSSHDRHMAFDDMCKLSLTQNVLPRLRLFEPNDAVICGWGVMIKYLCAALYQRKELEIKIAVLSDSDVPVVPGMNIMVSRPEYIRGGKESARLLLAQIHKEQYESRIVIAPTPPAYVKI
>NC_014376.1|WP_013274492.1|4255413_4256421_+|acetyl-esterase
MKFHMPEYKIDYEVNKPDPYPLLSEGMKKVIDYQAEHSADAFDTNCSWDELRTKYVEERRFWNEGGPNPFKTVELTVEGPIGPIPVRIYYPDDKPQHHALVFIHGGGFTVGSIDTHDRMMRSVMASSKCAVIGVDYHLAPETKFPVPLFECTAVIRYFHEHGSKYGILPDKMAVGGDSGGANLALGATLYLRDVFGDNDYICALLLYYGSFGLMDGPSWRLNGTSLDGMRKGDMSAYISYYLENPSLDGENPYFATLNNDLTHGIPAAYLCCGSLDPLLGDSQALHNILALHGIHTEFELVPGVLHAFMHYGRMMDEALDCLKHSGEFYASILEE
>NC_014376.1|WP_013274490.1|4253939_4254650_+|DUF421-domain-containing-protein
MKYLEILFRIITILPMFLVITLLTGRRKIGELPVFDFLSLLAVGAVVGADIADPDIEHWPTAYAVILIMLLHYIYSIVLVKSKRVGKLLTFEPVVVIENGQFVKGNMKKLKYSIDNILTLLRDKDVFDLNEVEFAIIESTGQLSVLKKSQYQPITPSEIKINTDYVGLSIPLIVEGTIYKENLERLNLDEKWLSSQLKTNNVASEKDVFYAAFNTKGELYISVGKEKSSSLHDLRH
>NC_014376.1|WP_013274489.1|4253146_4253857_+|DUF421-domain-containing-protein
MDYLIIFLRIITILPLFLFITMLTGRRKIGELPVFDFLTILVLGSVVGADIADPKVEHLPTVFSVIIIMLLHYIYSIIIIKNRNLGKWLTFEPVVVIENGDFVKGNMKKLKYSIDNILALLREKDVFDISEVEFAVIESTGQLSVQIKSQFQPLTPSEINLDTEYKGLALPLIVEGKVYKHNLQKLGLDDDWLREQLSENNIHSVKEIFFASINSQGNLYISKGLEKPREIGILRH
>NC_014376.1|WP_013274488.1|4251097_4252513_-|DEAD/DEAH-box-helicase
MQFKDLNIIPDIIKALEKESYLIPTPIQEEAIPVILSGRDLLGCAQTGTGKTAAFAIPTIQLLREEKESHGAKQNIRALIVTPTRELALQIYESFNTYGKFTDLKCCVVFGGVSQKPQEEKLKQRVDILVATPGRLLALIDQKIVNIDHIKILILDEADRMLDMGFIHDVKKIIARTPLKKQTLLFSATMPPDIAKLAGTILKAPAKIEITPVSSTVDTIGQYVYFVDKSNKKDLLLHVLKDNNIVSALVFTRTKHGADRLNKQLSRNNVIAQAIHGDKSQGARQSALNNFKNKSLRILIATDIAARGIDIDELTHVINYDLPDIPETYVHRIGRTGRAGLGGTAISFCDYDEKEQLNDIERLIGKKITEIKDHPYPLKNNVPGIKAVQPRREAAKTEKTKAKHPERAFLKSKASLQTASLKPGVSSKREPLHTSSVDGASATKKKYRMTADGTLKEKKSFHKFSRKDKKW
>NC_014376.1|WP_013274487.1|4249562_4250576_-|DUF4489-domain-containing-protein
MNLSIKSNINDDCGDSIKGCGSNRTILKCGEISQALFFNGAGIGTTLPAATITLDTSKLCNSCIMLEFSSNIIGTLFQGTLNFQLYRSCNDQLPIPIGPQYYFTQSVPAYFANMFSFFVCDCDLCSNDCCTYSIVVSAGGSAPIIGNAGIFAARLAAIITDDPEHDDECYPCNQLCQKGNKAILKCGTPGGVISITPDTLADTTFTASTLSLNTSSLCNPCMKLEFASTIAYSSPTTIDSTVVSFQVFKLCSNQLNPIPVGPQLVFSVPFTTAIIPPVAPGFSGTSTFSFFVCDCDICHDECCTYSVVATTATADASVTINNVNFSAIAADHDCRCC
>NC_014376.1|WP_013274486.1|4249246_4249486_+|hypothetical-protein
MNRDKLIAQVKNEYARIASTESQQHFHQTTTDLTPEAYYENLLGMAISEINRGTFDNFKSGEEVVTAIANDKTWLSEWK
>NC_014376.1|WP_013274485.1|4249068_4249218_+|hypothetical-protein
MSKDSQLDPKSIRKKKANGGPTMAESALDGESRNTKKQSGSRHKPGNDK
>NC_014376.1|WP_041709508.1|4246510_4248700_-|AAA-family-ATPase
MINSQMELEFENTRFKQTIALAREQLDQARERNEVNKSAIISAKKELRENTSHSISNLWSSEGFEALAALNQYANPIADKIADYEAVENKIARLENMIQSPYFARIDFRFEDEEEFEKIYIGRSSLKKDSTNQFFVYDWRSPIASVFYRFVLGQVFYDAPGGRITGQVSLKRQYEISKGKLEYFFDADVQIVDEFLRKLLSQNTSPKMKTIVETIQREQDIVIRDMENDLMMVQGVAGSGKTSIALHRAAYLMYQGLSNKLSADNILIISPNTLFEQYISNVLPELGEDHVVSVVFEDIIASVLKNEQVQSRNQFLENLISNTSYRNRIKRSMEFKTSRQFLEILDRFMADLPHHWMDFKDVIYDGECIISKEALKEKILSGRNETPLGSRLKLIKEYILELISESKKYRLKKTEQVVLKEELLKFMELDLKDVYRKLFHEKEYFYSLADGIIPPGSIDDILADTQDNLNTDMLYYDDATILTYLNLKLYGANKYKAIKQVVIDEAQDYYPLHFEIFHFLFPKAKFTILGDINQTLEKNEDLSLYQEIRRILHRKKSTLVTMDKSFRCTNEILNYGIRFLEVRSEIKSFNRKGDEPRRYEEKDQLSFLNRIITEVNACLEMGYQSIGLICKTEKNALSLFESLKDRADVQLVKNGGSADLHGVFIILVYMSKGLEFDSVLICDADGKNYHSKDDKKLLYIACTRALHRLSLFCLGEASPLLDGNNIGNC
>NC_014376.1|WP_013274483.1|4243498_4245994_-|LuxR-family-transcriptional-regulator
MQKKFNQRNKYFFSERLKRQLDQISHHPLTIVEAPSGFGKTTAVREYLREKVSHGACEYWYTCLGEPASMAWLGICELFSNVSIKVADDLKNMQMPTLDTLFFITAHLRDITCQMETYLVVDNYQLVNCDIPRELISVFSMHGNPKLHMIFITQQLEVRQQVSIHNNNIYTLDASPFFFDREGTANLFRMEGIRLTDDELEKIFMSTEGWVSAIRLHMINFKETGFFDPAADIEQLVERAIWNNLTPQERDFFLSVSILDSFSARQAAIMLNQEVLPDKIIEILKNNEFIRYLPDKYRYSMHSILQDYLRNRFYNEMPEDYQNRTFRRAGTSCVAVSRYYPASEFFFRIRDFDAILSLPFSIEYPDKQREKYQSELIVRIVHECPEKTLCSHPLTMIIFGYYTLMNGQTEVYQRLCSLLEQTVHRKGDFLPDEIRKIHGEYELLAAFGEFNDLSRMKERQKRAWEILGQPSEVIKEDAPWLFASPTVLGMFWRETGKLEHILKEIEESSPFYQRLVRGHGAGAFHVMQAEAMLMRGKDDEAEIHCHKALYEARGSRQASICISSELVLARIAILRGDVESYFKAIKRIQDYAKENTSLYVLHMVECCMSVISIELGIKDYVAPWLYDIESIKKMLYDPVIPHAQIFYLKLLLMEKRYNELYGISQLLLDNGKKQEKRIKYMLPQIYNLKFLAIAKYNNGHQLEALEYLKQALAAALPDKVYLPLIQDAGCLAPLYESLKNFIPDKDGINAVLELGRRHEKGMKIIRKAIISDKTPLTPREREIALLARNRLRAREIADKLCISETTVRTILRNVYSKLDIHSKTELDTKEF
>NC_014376.1|WP_013274494.1|4257939_4259226_-|MFS-transporter
MGKEKKSGKVITLILMMLSLNTIYVLPYLMYTYYAPLQEAMGLLGRDADYGKLLNVYGIANIILYIPGGMIADKFDAKKLLIFSMIGTGALGLWEATWPSYTILMIIHVAWAFTTVLTYWSASIKCINVIAGADEQGSMYGSLEAGRGIVGIILTTIFVGIFTKFSADSSKAMSYVVITCSVVMILVGIAMVFLMPVTNVEGSTNKGLLDSIKAMGQALSRPVTYLLSGMIFGACIAQAGISYLAPYLAKVCGMDQNMTVIFANYNRTICTLIGASIAAFAAKKMGRSSKFMIYAGFGSIVSYILLVLIPGSAVTMFPILVIMVFSTLCYPVFRALYYAVVDELGTQKNVVGSVIGIASILGFLPDTFYTSMCGARLEADPVGGYKFVFITCMAAMALGLICAFISDRKILKYRKTDEYKATIKQADM
>NC_014376.1|WP_013274495.1|4259330_4260944_-|sodium:solute-symporter-family-protein
MSIYFWGVIISIVIYMVVGLYAGSQVRDANDYYVSGRNAPTFLITGTLIASMLSVNGFMGDQGWCYTGNITSLVLLNSMCACGYVLGPLVFGRYLRRSECTTMPEYFGVRYHDRKIRRVAGIITIVSLTAYLLACITGVGILIQELTGLPYEVTLFLAWLCFTVFTFYSGSKGVVLTDTLMFLVFLLGVILAGPIIFKAQGGIGKLLTNLMNNPAAPQGLLDYHGNIAGTGAKDVFGAVMYAVTMGIIWLITVAVSPWQAGRNLMAKSEHVTFRSGAVAAICTVVFLLFLNLQSVAVLNLNGGLEDPQRVLIWASFEVLPKLIGTLLLAGITAAGLSSASTFLSVIGFSVTSDIIDRKFNSEEEKLKHSRIMMLIVGILALMLAYVGLGGVRVISWFASTIIAASWVVPGIGGIVCKKLSATGARWAMISGFLGFVIPKSLVGLGISPFAGVFVNFLDPFFIGIYLSLFFALIGTKLHQAGTEEMEYHEKLMILPDKEKAASEYKRDRRYGYILIIAGVITTLVLLFGWALPYNGMI
>NC_014376.1|WP_013274497.1|4261152_4262295_-|acyl-CoA-dehydrogenase
MEFKLNDEQELLRDTIREFVEAEIAPIAAELDREERFPEELIPQLGEIGVMGIPIPEEYGGVGMGDLECAMAVEEISKACASTGVTVSIHTSFCCWPILAFGTEEQKQKYLPDLAAGEKLGAFGLTEPNAGTDAAMQATTASDEGDHYLLNGSKIFITNGSYADVYIIFAVTDKKLGKKGISAFILEKGMEGFTFGSKEHKMGIRGSATYELVFDNVKVPKENLLGEAGKGFKIAMATLDGGRIGIAAQALGIAQGAIDAAAAYVKERIQFGKPISAFQNTQFTLADMQTRVDAARLLVYRAACMKTAGEKYTAQASMAKLYASETAGYVTSKAVQLFGGYGYTREYPVERMMRDAKITEIYGGTSEVQKMVIAADMGMK
>NC_014376.1|WP_013274498.1|4262330_4263467_-|acyl-CoA-dehydrogenase
MDFRITEEQELMVQAIEEALTRENLESYFQECDRNHEHPHKFWDILKELGCFSMFLPEEAGGDGEGAITMLLVMEALGRCGTPVYLFWDHVKADALLENGTKEQIEKFMPLFFEGHPAYAQGFSEPTAGTDLSSGTILTTYTRRNGKVYINGHKHFISGAQGSDYCLTLAKNSENPEQLTLWFVPTNGPGCKKEPMETMGLHMENVNDIWFDDVEIEEKDMFSTEGNGLLATSKGFDYERLIDAFNAYAQALCAYEDACRYANQRIAFGKEIGRLQLIQNHIMEMAMRIEAMRDMLLRYAWNKDNGLLRREEASIAKQFCSESANIVVDHAMQVMAGIGFCGSRVSRIYRDLRITRISGGTGEIQTVIASKQILKRYR
>NC_014376.1|WP_013274499.1|4263528_4264302_-|enoyl-CoA-hydratase
MENQKVLTELRDEVLIVTINRDERRNAIDPETSARLEEIFNDAEKDSKVRCIIITGAGERSFCAGEDLSAYDENGGCQTIMAHGFAGITERVSTKPIICAANGTAVAGGLEIAVSCDLIVAAEHAKFGLSEVKVGLLATSGGLIRLPKLVPPKIAAEMCLTGKLISASRAYEIGLVNYVVPSDQVLIKALELAHIIAANAPISLKLTKEILHIAPQVSQEDAQRFCNRCWDYIEKTEDSVEGPRAFLEKRKPDWKGK
>NC_014376.1|WP_013274500.1|4264318_4264966_-|MBL-fold-metallo-hydrolase
MEVQRLVLGIFNTNCYIISGKSLGKCILIDPADDAENIRKWLVQQNLVPEAILLTHGHYDHFLAVPKLQAFWKELPVYCHLLDCPMEKEEHDMGMVFPTVTALSNVRGIEEGQKLWLAGFEITVCHTPGHTKGSVLFLVEDGLFTGDTLFCNSIGRTDFPGGDDAQMHLSLRRISEIKGDYNVYPGHEGLTTLSAEKKYNPYLQCFCKDSGRLYQ
>NC_014376.1|WP_013274501.1|4264999_4266214_-|CoA-transferase
MAKWESKGVFKGMKVLDFTIALAGVYTAWQFADLGAEVWKVERYNAGDQSRTWDPFVNGMSTLYCAYNKNKQSIELDLSSAEGKNVIYEMVKQCDVVLENFKSGSIDRLGLGYDKLKEINPGIVFMSLSGFGASGPLMKYPCYDAIAAARGGFAASNGEAEGAPVKAGNANCDTLTGIYGFNAVLMALIEARRTGKGCRIDIGMSDVVMEACAETVMDYGMEGKAQARFGNHDRFAAPYGIFEARDGWVSIVADTQEKWKALANTLGLADLLSDPRFATMEARIANREVLTERIEAVTRTMFRKEAEEKLLAVNVGASEVLPFIEAYTSDHANQTDVTALAWQDNIGFIRFYNNPIRFNDELCPIHRGSPLLGQDSRDILERAGYSREEIQKLIDDGVVGEHMF
>NC_014376.1|WP_013274502.1|4266245_4267430_-|CoA-transferase
MKPLCSLKILDMTDGNPYTGSMFADYGAEVLKIEKPDGGDSVRRRGAADDGEGIYQAFYNRGKKSMTLDINKEAGQEIIRRLIPQFDMLIVNKKEEDMKALGLGFESLKEKNPKLIYGVLTPYGENGPWKDMPDYDLLINSRSGLQEKTGFPEKPTKFGFPLGYIYAGWHLSAGMMAAYLSMQKTGEGVKVSVSVWHTLMSLDDTFAEGLLGMNALPKRIGNGFPTTNPTDTFRCKDGWFSLSIGSDAQWISFAQCAGRKDWAEDPRYAHDPARSMENYFGDLDQQLKDYFAAITIQEADMICREAMVPGGPCNTVMELVHDEQVADREMLLHIQDKKLGDTLQIGKAAKFSWDGKEDHVIDSAPLLGEDTDDYLAGINMGQAEIARLRADGVI
>NC_014376.1|WP_013274503.1|4267792_4268554_+|putative-electron-transfer-flavoprotein-FixA
MKIIACCKIVPNEEEISILPSRELSMTGASLKISQYDLNALETGKQLASETMGTMTALSVGPAAALTNSKIRKDILSRGADELSLVQDDSNESFDSLQTAKAIAGALKLMEYDVVICGAGSSDLYAQEVGIQTGTLLGIPVMNNVTGIKVLSESMLLVERTLEDEVETLEIPLPAVLSVSSEINIPAVPSMRDIMKAGKKPVNELNVEAKTDASAQTLEQLAPAVQDRRQEIIEGDGEEAVGALVQFLKKEGF
>NC_014376.1|WP_013274504.1|4268583_4269510_+|electron-transfer-flavoprotein-subunit-alpha
MAIPSIFIVSDNYAVLPEFCCGAKTLADHVTAIVFGDETAAKAAANCSADKIIFCPVAGEGAPEDYASAIAAEIKAVPNAIVLVNNSIRGHLLAGKISVYLDTAVISGANNLSVEEDQFICSRMVYGGTAQRKEVFTKPYGIVTIAGGMFDVVPDGGETTDIRAIEGAPEGSIRRISRNEKKEGAVNLAAAKRIVDIGRGLAAEEDLDMCRKLAKLLDAEVGCSRPIAENNKWMPKACYMGITGVQVKPDLIVTLGLSGQVQHIGGINKSKVIVAINKDKAAPIFKNADFGLVGDMYKIVPALIEKLS

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_014376_5	5.1\|2198131\|26\|NC_014376\|CRISPRCasFinder	2198131-2198156	26	NC_014376.1	2411581-2411606	2	0.923

1. spacer 5.1|2198131|26|NC_014376|CRISPRCasFinder matches to position: 2411581-2411606, mismatch: 2, identity: 0.923

agggtgtttccttaatcttgtccatg	CRISPR spacer
agggtgtttccttattcgtgtccatg	Protospacer
************** ** ********

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_014376_5	5.1\|2198131\|26\|NC_014376\|CRISPRCasFinder	2198131-2198156	26	NZ_CP030830	Neorhizobium sp. NCHU2750 plasmid pNCHU2750c, complete sequence	328743-328768	6	0.769
NC_014376_5	5.1\|2198131\|26\|NC_014376\|CRISPRCasFinder	2198131-2198156	26	NZ_CP030828	Neorhizobium sp. NCHU2750 plasmid pNCHU2750a, complete sequence	127351-127376	6	0.769

1. spacer 5.1|2198131|26|NC_014376|CRISPRCasFinder matches to NZ_CP030830 (Neorhizobium sp. NCHU2750 plasmid pNCHU2750c, complete sequence) position: , mismatch: 6, identity: 0.769

agggtgtttccttaatcttgtccatg	CRISPR spacer
ttccggtttccttgatcttgtccatg	Protospacer
     ********.************

2. spacer 5.1|2198131|26|NC_014376|CRISPRCasFinder matches to NZ_CP030828 (Neorhizobium sp. NCHU2750 plasmid pNCHU2750a, complete sequence) position: , mismatch: 6, identity: 0.769

agggtgtttccttaatcttgtccatg	CRISPR spacer
ttccggtttccttgatcttgtccatg	Protospacer
     ********.************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

563492 : 629490

Leptospira_phage(14.29%)

transposase,protease,holin,integrase

attL 555593:555608|attR 610088:610103

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
555593:555608	attL	NA	NA	NA	NA
WP_013271232.1\|563492_564332_+\|holin	LPS cholinephosphotransferase	A0A1V0SD50	Indivirus	2.6e-07	46.3
WP_013271233.1\|564437_565973_-	BCCT family transporter	NA	NA	NA	NA
WP_157669055.1\|566248_566821_+	hypothetical protein	NA	NA	NA	NA
WP_013271235.1\|566908_567889_-	zinc dependent phospholipase C family protein	NA	NA	NA	NA
WP_013271236.1\|568173_569559_+	sodium:alanine symporter family protein	NA	NA	NA	NA
WP_013271237.1\|569626_569866_-	hypothetical protein	NA	NA	NA	NA
WP_013271238.1\|569998_570910_-	AraC family transcriptional regulator	NA	NA	NA	NA
WP_013271239.1\|571113_571503_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_013271240.1\|571522_572116_+\|protease	ATP-dependent Clp protease proteolytic subunit	A0A223W000	Agrobacterium_phage	2.0e-43	49.5
WP_013271241.1\|572454_572718_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_013271242.1\|572689_573145_+	peptide deformylase	A0A2I7R224	Vibrio_phage	2.9e-13	36.0
WP_013271243.1\|573195_574356_+	MFS transporter	NA	NA	NA	NA
WP_081442994.1\|574613_574778_+	DUF255 domain-containing protein	NA	NA	NA	NA
WP_081442995.1\|574790_576677_+	thioredoxin domain-containing protein	NA	NA	NA	NA
WP_013271244.1\|576864_577830_+	choloylglycine hydrolase family protein	A0A2K9L5Y5	Tupanvirus	4.7e-21	26.0
WP_013271245.1\|578373_579687_-\|transposase	IS30 family transposase	H7BUM7	unidentified_phage	3.4e-14	30.2
WP_013271246.1\|579965_580484_+	peptidylprolyl isomerase	A0A1B1IVS0	uncultured_Mediterranean_phage	7.8e-23	43.6
WP_013271247.1\|580488_581238_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_013271248.1\|581173_581875_-	hypothetical protein	NA	NA	NA	NA
WP_013271249.1\|582124_582907_+	YesL family protein	NA	NA	NA	NA
WP_013271250.1\|583069_583648_+	(p)ppGpp synthetase	NA	NA	NA	NA
WP_013271251.1\|583768_584980_-	ammonium transporter	H8ZJB2	Ostreococcus_tauri_virus	3.8e-60	37.4
WP_013271252.1\|585216_585555_-	P-II family nitrogen regulator	NA	NA	NA	NA
WP_013271253.1\|585835_586741_+	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase	NA	NA	NA	NA
WP_013271254.1\|586730_587405_+	GntR family transcriptional regulator	NA	NA	NA	NA
WP_013271255.1\|587421_587637_+	hypothetical protein	NA	NA	NA	NA
WP_013271256.1\|587799_588423_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_013271257.1\|588446_589589_+	efflux RND transporter periplasmic adaptor subunit	NA	NA	NA	NA
WP_013271258.1\|589601_592661_+	efflux RND transporter permease subunit	S5VTK5	Leptospira_phage	1.4e-87	24.6
WP_013271259.1\|592794_593946_+	TolC family protein	NA	NA	NA	NA
WP_013271260.1\|593949_595146_+	TolC family protein	NA	NA	NA	NA
WP_013271261.1\|595126_595774_-	stage II sporulation protein R	NA	NA	NA	NA
WP_013271262.1\|595871_596936_+	D-alanine--D-alanine ligase	NA	NA	NA	NA
WP_013271263.1\|597061_597880_+	glutamate racemase	NA	NA	NA	NA
WP_013271264.1\|597893_598340_+	DUF1934 domain-containing protein	NA	NA	NA	NA
WP_013271265.1\|598382_599603_-	ATP-binding protein	NA	NA	NA	NA
WP_013271266.1\|599676_600522_-\|integrase	tyrosine-type recombinase/integrase	A0A0H4TI16	Erysipelothrix_phage	2.2e-14	27.3
WP_013271267.1\|600528_601389_-\|integrase	tyrosine-type recombinase/integrase	A0A0H4TI16	Erysipelothrix_phage	3.3e-18	29.3
WP_013271268.1\|601618_603331_+	cell wall-binding protein	NA	NA	NA	NA
WP_013271269.1\|604854_606399_+	polymerase	NA	NA	NA	NA
WP_081442996.1\|606623_606899_+	hypothetical protein	NA	NA	NA	NA
WP_049791693.1\|607319_608603_+	sugar transferase	NA	NA	NA	NA
WP_013271271.1\|608599_609742_+	glycosyltransferase family 4 protein	NA	NA	NA	NA
WP_013271272.1\|609735_610524_+	ABC transporter permease	NA	NA	NA	NA
610088:610103	attR	NA	NA	NA	NA
WP_041708413.1\|610545_611268_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	5.4e-14	27.9
WP_013271274.1\|611282_612419_+	glycosyltransferase	NA	NA	NA	NA
WP_013271275.1\|612423_613593_+	glycosyltransferase	NA	NA	NA	NA
WP_013271276.1\|613691_616031_+	glycosyltransferase	NA	NA	NA	NA
WP_081442998.1\|616618_616888_+	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_013271278.1\|617189_620165_+	hypothetical protein	NA	NA	NA	NA
WP_013271279.1\|620197_621622_+	hypothetical protein	NA	NA	NA	NA
WP_013271280.1\|621643_622066_+	WxcM-like domain-containing protein	NA	NA	NA	NA
WP_013271281.1\|622062_622989_+	glycosyltransferase family 2 protein	Q76H32	Enterobacteria_phage	1.4e-35	30.4
WP_013271282.1\|623002_623542_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_013271283.1\|623576_624680_+	DegT/DnrJ/EryC1/StrS family aminotransferase	E5ES42	Bathycoccus_sp._RCC1105_virus	4.2e-50	34.5
WP_013271284.1\|624676_625165_+	GtrA family protein	NA	NA	NA	NA
WP_013271285.1\|627063_627420_-	IS66 family insertion sequence element accessory protein TnpB	NA	NA	NA	NA
WP_013271286.1\|627412_627757_-	IS66 family insertion sequence hypothetical protein	NA	NA	NA	NA
WP_013271287.1\|627948_629490_-\|transposase	IS66 family transposase	S5VTD3	Leptospira_phage	7.7e-66	33.5

DBSCAN-SWA_2

800538 : 832128

unidentified_phage(21.05%)

terminase,capsid,tail,portal,protease,integrase

attL 808287:808302|attR 810559:810574

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_166431295.1\|800538_801585_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_013271426.1\|802134_802659_-	helix-turn-helix transcriptional regulator	A0A0A8WE86	Clostridium_phage	3.1e-11	35.7
WP_013271427.1\|802789_802972_+	hypothetical protein	NA	NA	NA	NA
WP_013271428.1\|803020_803182_+	hypothetical protein	NA	NA	NA	NA
WP_013271429.1\|803222_803390_+	hypothetical protein	NA	NA	NA	NA
WP_013271430.1\|803423_803591_+	hypothetical protein	NA	NA	NA	NA
WP_157668987.1\|803920_804277_+	HTH domain-containing protein	NA	NA	NA	NA
WP_013271433.1\|804279_804591_+	hypothetical protein	NA	NA	NA	NA
WP_013271434.1\|804784_805567_+	hypothetical protein	NA	NA	NA	NA
WP_013271435.1\|805580_805811_+	hypothetical protein	NA	NA	NA	NA
WP_013271436.1\|805807_806023_+	hypothetical protein	NA	NA	NA	NA
WP_013271437.1\|806083_806530_+	nuclease	A0A088F897	Idiomarinaceae_phage	7.7e-11	37.7
WP_013271438.1\|806526_807309_+	ParA family protein	H7BUL8	unidentified_phage	5.8e-46	37.8
WP_013271439.1\|807309_808368_+	ParB N-terminal domain-containing protein	H7BUL7	unidentified_phage	5.9e-33	36.4
808287:808302	attL	NA	NA	NA	NA
WP_013271440.1\|808496_809504_+\|integrase	tyrosine-type recombinase/integrase	A0A2H4J4W0	uncultured_Caudovirales_phage	1.5e-75	88.0
WP_013271441.1\|809688_809841_+	hypothetical protein	NA	NA	NA	NA
WP_013271442.1\|809833_810796_+	hypothetical protein	A0A1C8E9A9	Bacillus_phage	2.2e-15	23.5
810559:810574	attR	NA	NA	NA	NA
WP_049791634.1\|810933_811677_+	hypothetical protein	NA	NA	NA	NA
WP_013271444.1\|811673_811949_+	hypothetical protein	NA	NA	NA	NA
WP_013271445.1\|811989_812166_+	hypothetical protein	NA	NA	NA	NA
WP_049791635.1\|812396_812867_+	phosphoadenosine phosphosulfate reductase family protein	NA	NA	NA	NA
WP_041708866.1\|812893_813301_+	phosphoadenosine phosphosulfate reductase family protein	NA	NA	NA	NA
WP_013271447.1\|813452_813728_+	hypothetical protein	NA	NA	NA	NA
WP_013271448.1\|813738_813951_+	hypothetical protein	NA	NA	NA	NA
WP_013271449.1\|813995_814217_+	hypothetical protein	NA	NA	NA	NA
WP_013271450.1\|814249_814627_+	HNH endonuclease	Q7Y4J8	Streptococcus_phage	1.6e-25	51.4
WP_013271452.1\|814791_815028_+	hypothetical protein	NA	NA	NA	NA
WP_013271453.1\|815057_815300_+	hypothetical protein	NA	NA	NA	NA
WP_013271454.1\|815393_815813_+	DUF3775 domain-containing protein	NA	NA	NA	NA
WP_041708445.1\|815888_816695_+	DNA adenine methylase	A0A2H4JFS7	uncultured_Caudovirales_phage	1.1e-132	92.9
WP_013271456.1\|816750_817101_+	hypothetical protein	NA	NA	NA	NA
WP_041708447.1\|817097_817313_+	hypothetical protein	NA	NA	NA	NA
WP_013271457.1\|817324_817552_+	hypothetical protein	NA	NA	NA	NA
WP_013271458.1\|817596_817998_+	hypothetical protein	NA	NA	NA	NA
WP_013271459.1\|818191_818533_+	HNH endonuclease	NA	NA	NA	NA
WP_013271460.1\|818716_819040_+	hypothetical protein	NA	NA	NA	NA
WP_013271461.1\|819029_820712_+\|terminase	terminase	A0A1B1P766	Bacillus_phage	7.5e-99	35.9
WP_013271462.1\|820730_821909_+\|portal	phage portal protein	E2ELI3	Clostridium_phage	9.3e-72	39.1
WP_013271463.1\|821925_822684_+\|protease	Clp protease ClpP	A0A0K2CZ28	Paenibacillus_phage	1.5e-27	34.8
WP_013271464.1\|822688_823867_+\|capsid	phage major capsid protein	E2ELI5	Clostridium_phage	3.3e-85	47.6
WP_013271465.1\|823968_824262_+	hypothetical protein	NA	NA	NA	NA
WP_013271466.1\|824236_824584_+	hypothetical protein	NA	NA	NA	NA
WP_049791695.1\|824632_824965_+	HK97 gp10 family phage protein	A0A1X9I688	Streptococcus_phage	5.9e-16	47.7
WP_013271468.1\|824961_825294_+	hypothetical protein	A0A0U4JNN6	Exiguobacterium_phage	1.3e-18	41.5
WP_013271469.1\|825283_825853_+\|tail	tail protein	A0A0U4JWV5	Exiguobacterium_phage	4.0e-44	48.9
WP_013271470.1\|825856_826231_+	hypothetical protein	A0A290GJX3	Caldibacillus_phage	1.8e-13	40.4
WP_013271472.1\|826403_829040_+\|tail	phage tail tape measure protein, TP901 family	H7BVF3	unidentified_phage	7.6e-90	55.3
WP_157668988.1\|829060_829750_+	mtfA protein	NA	NA	NA	NA
WP_013271474.1\|829749_831684_+	phage minor structural protein	H7BV46	unidentified_phage	4.6e-60	31.8
WP_013271475.1\|831753_832128_+	hypothetical protein	A0A2H4JD81	uncultured_Caudovirales_phage	7.9e-09	34.4

DBSCAN-SWA_3

881194 : 931909

Faecalibacterium_phage(60.0%)

tail,plate,holin,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013271529.1\|881194_882244_+\|tRNA	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	NA	NA	NA	NA
WP_041708882.1\|882320_882983_+	redox-sensing transcriptional repressor Rex	NA	NA	NA	NA
WP_013271531.1\|883000_883918_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_013271532.1\|884047_885238_+	iron-containing alcohol dehydrogenase	NA	NA	NA	NA
WP_157669059.1\|885377_886181_+	sirohydrochlorin cobaltochelatase	NA	NA	NA	NA
WP_013271534.1\|886177_887179_+	FAD:protein FMN transferase	NA	NA	NA	NA
WP_013271535.1\|887321_887747_+	GtrA family protein	NA	NA	NA	NA
WP_013271536.1\|887762_890645_+	YfhO family protein	NA	NA	NA	NA
WP_013271537.1\|890713_892087_+	argininosuccinate lyase	NA	NA	NA	NA
WP_013271538.1\|892343_893429_+	TRAP transporter substrate-binding protein	NA	NA	NA	NA
WP_013271539.1\|893496_894021_+	TRAP transporter small permease	NA	NA	NA	NA
WP_013271540.1\|894020_895313_+	TRAP transporter large permease	NA	NA	NA	NA
WP_013271541.1\|895459_895942_+	YcxB family protein	NA	NA	NA	NA
WP_013271542.1\|895950_896841_-	L-serine ammonia-lyase, iron-sulfur-dependent, subunit alpha	NA	NA	NA	NA
WP_013271543.1\|896855_897515_-	L-serine ammonia-lyase, iron-sulfur-dependent, subunit beta	NA	NA	NA	NA
WP_013271544.1\|897553_898351_-	histidinol-phosphatase HisJ family protein	NA	NA	NA	NA
WP_013271545.1\|898573_900244_+	Na/Pi cotransporter family protein	NA	NA	NA	NA
WP_013271546.1\|900365_901397_+	type I glyceraldehyde-3-phosphate dehydrogenase	NA	NA	NA	NA
WP_013271547.1\|901487_902699_+	phosphoglycerate kinase	NA	NA	NA	NA
WP_013271548.1\|902825_903578_+	triose-phosphate isomerase	NA	NA	NA	NA
WP_013271549.1\|903828_905367_+	2,3-bisphosphoglycerate-independent phosphoglycerate mutase	NA	NA	NA	NA
WP_013271550.1\|906781_908560_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	7.0e-55	29.7
WP_013271551.1\|908714_909581_+	DegV family protein	NA	NA	NA	NA
WP_013271552.1\|909608_911051_+	HAMP domain-containing histidine kinase	W8CYF6	Bacillus_phage	2.4e-37	33.2
WP_041708883.1\|911080_912061_+	lipoprotein	NA	NA	NA	NA
WP_157669060.1\|912123_914571_+	DUF4131 domain-containing protein	Q332C0	Clostridium_botulinum_C_phage	6.1e-33	29.6
WP_013271555.1\|914659_915631_+	DNA polymerase III subunit delta	NA	NA	NA	NA
WP_013271556.1\|915825_916008_-	hypothetical protein	NA	NA	NA	NA
WP_013271557.1\|916062_916515_-	ImmA/IrrE family metallo-endopeptidase	A0A0A7RTX7	Clostridium_phage	1.4e-31	49.3
WP_013271558.1\|916538_917021_-	helix-turn-helix domain-containing protein	A0A2K9V426	Faecalibacterium_phage	1.3e-16	69.1
WP_013271559.1\|917161_917380_+	hypothetical protein	NA	NA	NA	NA
WP_013271560.1\|917492_917996_+	hypothetical protein	NA	NA	NA	NA
WP_013271561.1\|917992_918235_+	hypothetical protein	NA	NA	NA	NA
WP_013271562.1\|918236_919703_+\|tail	phage tail sheath family protein	A0A2K9V328	Faecalibacterium_phage	6.7e-120	45.2
WP_013271563.1\|919704_920220_+\|tail	phage major tail tube protein	A0A2K9V323	Faecalibacterium_phage	2.7e-31	42.3
WP_013271564.1\|920232_920577_+\|tail	phage tail assembly protein	NA	NA	NA	NA
WP_157668989.1\|920600_920747_+	hypothetical protein	NA	NA	NA	NA
WP_041708463.1\|920753_921053_+\|tail	phage tail tape measure protein	NA	NA	NA	NA
WP_049791638.1\|921388_924187_+\|tail	phage tail tape measure protein	H9A124	Staphylococcus_phage	6.9e-49	43.9
WP_013271565.1\|924188_924389_+\|tail	tail protein	A0A2K9V353	Faecalibacterium_phage	4.6e-08	47.2
WP_049791639.1\|924470_925658_+	LysM peptidoglycan-binding domain-containing protein	A0A2K9V340	Faecalibacterium_phage	2.8e-60	38.6
WP_013271566.1\|925671_926085_+\|plate	phage baseplate assembly protein V	A0A2K9V325	Faecalibacterium_phage	6.9e-14	48.3
WP_013271567.1\|926081_926471_+\|tail	phage tail protein	A0A2K9V364	Faecalibacterium_phage	3.8e-22	43.1
WP_013271568.1\|926481_926781_+	hypothetical protein	NA	NA	NA	NA
WP_013271569.1\|926780_927929_+\|plate	baseplate J/gp47 family protein	A0A2K9V320	Faecalibacterium_phage	4.6e-92	46.9
WP_013271570.1\|927921_928857_+	hypothetical protein	A0A2K9V337	Faecalibacterium_phage	5.6e-11	25.5
WP_013271571.1\|928903_929299_+	hypothetical protein	NA	NA	NA	NA
WP_013271572.1\|929317_929752_+	hypothetical protein	NA	NA	NA	NA
WP_041708466.1\|929744_930806_+	hypothetical protein	NA	NA	NA	NA
WP_013271574.1\|930941_931346_+	hypothetical protein	NA	NA	NA	NA
WP_013271575.1\|931338_931479_+	XkdX family protein	NA	NA	NA	NA
WP_013271576.1\|931489_931909_+\|holin	phage holin family protein	A0A0S2MVC4	Bacillus_phage	5.5e-19	40.9

DBSCAN-SWA_4

1473368 : 1513368

Clostridium_phage(24.14%)

terminase,plate,tail,capsid,portal,holin,integrase

attL 1473322:1473348|attR 1516767:1516793

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1473322:1473348	attL	NA	NA	NA	NA
WP_013272057.1\|1473368_1474454_-\|integrase	site-specific integrase	A0A2H4J8J9	uncultured_Caudovirales_phage	3.7e-67	41.6
WP_013272058.1\|1474633_1475041_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_013272059.1\|1475257_1475431_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_013272060.1\|1475452_1475707_+	hypothetical protein	A0A2H4JAH0	uncultured_Caudovirales_phage	4.7e-29	77.4
WP_013272061.1\|1475703_1475850_+	hypothetical protein	NA	NA	NA	NA
WP_013272062.1\|1475866_1476037_+	hypothetical protein	NA	NA	NA	NA
WP_013272063.1\|1476090_1477365_+	AAA family ATPase	A0A097BY67	Enterococcus_phage	9.2e-150	64.2
WP_013272064.1\|1477364_1478489_+	ATP-binding protein	A0A0K2CZH1	Paenibacillus_phage	2.2e-102	51.1
WP_013272065.1\|1478502_1478952_+	hypothetical protein	A0A0K2CZ91	Paenibacillus_phage	6.5e-26	42.3
WP_013272066.1\|1478954_1480538_+	DEAD/DEAH box helicase	A0A0K2CZF8	Paenibacillus_phage	4.7e-236	75.2
WP_013272067.1\|1480551_1482759_+	AAA family ATPase	A0A2I7SC35	Paenibacillus_phage	2.1e-279	63.2
WP_013272068.1\|1483077_1483476_+	RusA family crossover junction endodeoxyribonuclease	Q5YA86	Bacillus_phage	1.4e-48	65.9
WP_013272069.1\|1483472_1483682_+	hypothetical protein	NA	NA	NA	NA
WP_013272070.1\|1483731_1484100_+	hypothetical protein	NA	NA	NA	NA
WP_013272071.1\|1484113_1484461_+	hypothetical protein	NA	NA	NA	NA
WP_013272072.1\|1484554_1484782_+	hypothetical protein	NA	NA	NA	NA
WP_013271450.1\|1484814_1485192_+	HNH endonuclease	Q7Y4J8	Streptococcus_phage	1.6e-25	51.4
WP_013271452.1\|1485356_1485593_+	hypothetical protein	NA	NA	NA	NA
WP_013271453.1\|1485622_1485865_+	hypothetical protein	NA	NA	NA	NA
WP_085952057.1\|1485985_1486789_+	DNA cytosine methyltransferase	A0A0F7L3U1	uncultured_marine_virus	7.8e-46	36.4
WP_041708542.1\|1486818_1487013_+	hypothetical protein	NA	NA	NA	NA
WP_013272074.1\|1487002_1487200_+	hypothetical protein	NA	NA	NA	NA
WP_013272075.1\|1487168_1487420_+	hypothetical protein	NA	NA	NA	NA
WP_049791704.1\|1487459_1487879_+	hypothetical protein	NA	NA	NA	NA
WP_013272077.1\|1488215_1489157_+	hypothetical protein	NA	NA	NA	NA
WP_041708970.1\|1489362_1489647_+	hypothetical protein	NA	NA	NA	NA
WP_013272079.1\|1489786_1490602_+	DUF3825 domain-containing protein	NA	NA	NA	NA
WP_013272080.1\|1491188_1491374_+	hypothetical protein	NA	NA	NA	NA
WP_013272081.1\|1491444_1492146_+	helix-turn-helix domain-containing protein	A0A2P1JTW4	Anoxybacillus_phage	9.5e-48	56.6
WP_013272082.1\|1492138_1493425_+\|terminase	PBSX family phage terminase large subunit	M4ZRM5	Bacillus_phage	1.0e-127	55.4
WP_013272083.1\|1493435_1494842_+\|portal	phage portal protein	A0A0A7S0I9	Clostridium_phage	7.3e-148	57.4
WP_013272084.1\|1494841_1496416_+\|capsid	minor capsid protein	Q20DD6	Lactobacillus_phage	8.2e-31	27.3
WP_013272085.1\|1496412_1496688_+	hypothetical protein	NA	NA	NA	NA
WP_013272086.1\|1496971_1497565_+	minor structural GP20 protein	A0A0A7S0J5	Clostridium_phage	9.8e-46	52.9
WP_013272087.1\|1497595_1498594_+	hypothetical protein	A0A0A7RVZ1	Clostridium_phage	1.9e-110	63.9
WP_013272088.1\|1498603_1498957_+	hypothetical protein	NA	NA	NA	NA
WP_013272089.1\|1498949_1499288_+	hypothetical protein	NA	NA	NA	NA
WP_013272090.1\|1499284_1499791_+	HK97 gp10 family phage protein	NA	NA	NA	NA
WP_013272091.1\|1499780_1500200_+	hypothetical protein	NA	NA	NA	NA
WP_013272092.1\|1500201_1501242_+\|portal	phage portal protein	Q708M0	Streptococcus_phage	1.2e-35	28.9
WP_013272093.1\|1501253_1501727_+\|tail	phage tail tube protein	A0A0A7RVP1	Clostridium_phage	3.9e-21	36.7
WP_013272094.1\|1501775_1502186_+\|portal	phage portal protein	S6B9X5	Thermus_phage	2.7e-18	40.3
WP_013272095.1\|1502206_1502356_+	hypothetical protein	NA	NA	NA	NA
WP_157669070.1\|1502385_1504332_+	tape measure protein	S6AVU8	Thermus_phage	8.7e-75	33.3
WP_013272097.1\|1504331_1504994_+	LysM peptidoglycan-binding domain-containing protein	A0A0K2SUI2	Clostridium_phage	1.7e-17	30.8
WP_013272098.1\|1505006_1505972_+	hypothetical protein	H7BVH4	unidentified_phage	5.3e-33	32.7
WP_013272099.1\|1505986_1506271_+	DNA helicase	NA	NA	NA	NA
WP_013272100.1\|1506272_1506659_+	DUF2634 domain-containing protein	A0A0A7RTH1	Clostridium_phage	1.2e-23	48.0
WP_013272101.1\|1506655_1507666_+\|plate	baseplate J/gp47 family protein	S6AVU3	Thermus_phage	2.0e-75	49.6
WP_013272102.1\|1507670_1508204_+	DUF2313 domain-containing protein	S6BFJ0	Thermus_phage	8.3e-28	44.7
WP_013272103.1\|1508204_1509440_+	hypothetical protein	Q9T1A4	Listeria_phage	9.0e-09	23.8
WP_013272104.1\|1509452_1509899_+	hypothetical protein	NA	NA	NA	NA
WP_013272105.1\|1509910_1510048_+	XkdX family protein	NA	NA	NA	NA
WP_041708545.1\|1510063_1510498_+\|holin	phage holin family protein	A0A090D848	Clostridium_phage	1.7e-26	52.0
WP_013272107.1\|1510566_1511400_+	hypothetical protein	NA	NA	NA	NA
WP_041708976.1\|1511455_1511953_-	hypothetical protein	NA	NA	NA	NA
WP_013272109.1\|1512069_1512993_-	DNA ligase	A0A2H4JD86	uncultured_Caudovirales_phage	2.7e-159	87.3
WP_013272110.1\|1513056_1513368_-	hypothetical protein	A0A2H4J6S9	uncultured_Caudovirales_phage	1.5e-37	72.8
1516767:1516793	attR	NA	NA	NA	NA

DBSCAN-SWA_5

1798431 : 1883810

Bacillus_phage(33.33%)

capsid,transposase,protease,portal

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013271927.1\|1798431_1798887_+\|transposase	IS200/IS605 family transposase	A0A1P8BMC0	Lactococcus_phage	4.2e-20	36.8
WP_013272379.1\|1798983_1799271_-	hypothetical protein	NA	NA	NA	NA
WP_081443012.1\|1799394_1800480_+	P1 family peptidase	NA	NA	NA	NA
WP_013272381.1\|1800476_1800731_-	hypothetical protein	NA	NA	NA	NA
WP_013272382.1\|1800957_1801941_+	porphobilinogen synthase	NA	NA	NA	NA
WP_013272383.1\|1801965_1802820_-	PHP domain-containing protein	NA	NA	NA	NA
WP_013272384.1\|1803001_1804720_+	vanomycin resistance protein VanB	NA	NA	NA	NA
WP_013272385.1\|1804918_1808458_+	pyruvate:ferredoxin (flavodoxin) oxidoreductase	NA	NA	NA	NA
WP_013272386.1\|1808624_1808966_-	DUF805 domain-containing protein	NA	NA	NA	NA
WP_013272387.1\|1809272_1810148_+	DUF4397 domain-containing protein	NA	NA	NA	NA
WP_013272388.1\|1810234_1810660_+	GntR family transcriptional regulator	NA	NA	NA	NA
WP_013272389.1\|1810625_1811525_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	1.5e-21	28.4
WP_013272390.1\|1811499_1813677_+	ABC transporter permease	NA	NA	NA	NA
WP_013272392.1\|1814402_1816331_+	LTA synthase family protein	NA	NA	NA	NA
WP_013272393.1\|1816420_1817527_-	DUF362 domain-containing protein	NA	NA	NA	NA
WP_013272394.1\|1817673_1818957_+	O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase	NA	NA	NA	NA
WP_013272395.1\|1819122_1820673_+	cardiolipin synthase	NA	NA	NA	NA
WP_013272396.1\|1820778_1822737_-	collagen-like protein	NA	NA	NA	NA
WP_013272397.1\|1823191_1823929_-	hypothetical protein	NA	NA	NA	NA
WP_157669008.1\|1823940_1824351_-	DUF4489 domain-containing protein	NA	NA	NA	NA
WP_013272399.1\|1824723_1825257_-	DUF4489 domain-containing protein	NA	NA	NA	NA
WP_013272400.1\|1825402_1827208_-	heparinase	NA	NA	NA	NA
WP_013272401.1\|1827781_1829563_+	sensor histidine kinase	NA	NA	NA	NA
WP_013272402.1\|1829559_1831113_+	response regulator	NA	NA	NA	NA
WP_013272403.1\|1831307_1832684_+	carbohydrate ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_013272404.1\|1832758_1833652_+	sugar ABC transporter permease	NA	NA	NA	NA
WP_013272405.1\|1833653_1834487_+	carbohydrate ABC transporter permease	NA	NA	NA	NA
WP_013272406.1\|1834577_1837607_+	DUF4981 domain-containing protein	L0N6M2	Herpes_simplex_virus	1.6e-144	31.7
WP_013272407.1\|1837935_1838349_+	DUF3788 domain-containing protein	NA	NA	NA	NA
WP_013272408.1\|1838602_1840090_+	aldehyde dehydrogenase family protein	NA	NA	NA	NA
WP_013272410.1\|1840571_1842314_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	7.6e-46	27.6
WP_013272411.1\|1842289_1844065_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	2.8e-51	27.1
WP_013272412.1\|1844127_1844988_+	patatin family protein	NA	NA	NA	NA
WP_013272413.1\|1845536_1847825_+	DNA helicase PcrA	A7KV33	Bacillus_phage	3.0e-135	42.3
WP_013272414.1\|1848017_1848308_+	hypothetical protein	NA	NA	NA	NA
WP_013272415.1\|1848419_1849781_+	23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD	A0A2K5B251	Erysipelothrix_phage	2.7e-54	33.3
WP_013272416.1\|1849974_1851144_+	hypothetical protein	NA	NA	NA	NA
WP_041708581.1\|1851454_1851871_+	hypothetical protein	NA	NA	NA	NA
WP_157669009.1\|1852412_1852661_+	hypothetical protein	NA	NA	NA	NA
WP_041709044.1\|1853191_1853656_+	hypothetical protein	NA	NA	NA	NA
WP_013272418.1\|1855574_1855895_+	hypothetical protein	NA	NA	NA	NA
WP_157669079.1\|1855920_1856469_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_013272420.1\|1856440_1858393_-	sensor histidine kinase	NA	NA	NA	NA
WP_013272421.1\|1858385_1860647_-	LPXTG cell wall anchor domain-containing protein	NA	NA	NA	NA
WP_013272422.1\|1860643_1861369_-	response regulator transcription factor	NA	NA	NA	NA
WP_013272423.1\|1861584_1861965_+	hypothetical protein	NA	NA	NA	NA
WP_013271245.1\|1865105_1866419_-\|transposase	IS30 family transposase	H7BUM7	unidentified_phage	3.4e-14	30.2
WP_013272425.1\|1866585_1872777_+	S-layer protein	NA	NA	NA	NA
WP_085952047.1\|1873163_1874569_-\|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	1.4e-53	43.8
WP_013272428.1\|1874759_1875290_+	RNA polymerase sigma24 factor	NA	NA	NA	NA
WP_013272429.1\|1875725_1876763_+	Rad3-related DNA helicase-like protein	NA	NA	NA	NA
WP_013272430.1\|1876759_1877200_+	hypothetical protein	NA	NA	NA	NA
WP_157669010.1\|1877289_1877433_+	hypothetical protein	NA	NA	NA	NA
WP_013272431.1\|1877486_1877744_+	hypothetical protein	NA	NA	NA	NA
WP_166431291.1\|1879251_1879581_+	hypothetical protein	NA	NA	NA	NA
WP_013272432.1\|1879917_1880184_+	type II toxin-antitoxin system Phd/YefM family antitoxin	NA	NA	NA	NA
WP_013272433.1\|1880173_1880479_+	type II toxin-antitoxin system RelE/ParE family toxin	NA	NA	NA	NA
WP_013272434.1\|1880554_1881820_+\|portal	phage portal protein	Q6DMU2	Streptococcus_phage	2.0e-189	76.0
WP_013272435.1\|1881877_1882588_+\|protease	Clp protease ClpP	A0A1B0RXE1	Streptococcus_phage	8.9e-78	65.8
WP_013272436.1\|1882601_1883810_+\|capsid	phage major capsid protein	A0A2I4R671	Erysipelothrix_phage	2.9e-153	68.5

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_014376

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection