CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_014377	Thermosediminibacter oceani DSM 16646, complete sequence	8 crisprs	cas8b1,cas7b,cas5,cas3,cas4,cas1,cas2,cas6,csa3,cas10,csm2gr11,csm3gr7,csm4gr5,csm5gr7,csx1,csx3,DEDDh	6	12	5	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_014377_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014377_1

73465-78146

TypeI-B

Consensus_repeat	Method
GTTACTAGCTTACCTATGAGGGGTTGAAAC	PILER-CR
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CRISPRCasFinder
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CRT

69 spacers

cas2,cas1,cas4,cas3,cas5,cas7b,cas8b1,cas6

The CRISPR arrays of NC_014377_1

>merge|NC_014377|1|73465-78146|PILER-CR,CRISPRCasFinder,CRT
GTTACTAGCTTACCTATGAGGGGTTGAAACGAGCTGATATAACTGATAATGCTGGTGGAATAGCTGAGTTACTAGCTTACCTATGAGGGGTTGAAACCCCCTACTTTAAATTTGTCCGCTATGCTCGCTTTCGGTTACTAGCTTACCTATGAGGGGTTGAAACTCCAGTAACTCCTGTATGACTTTCTTCTTCATATCTCGCGTTACTAGCTTACCTATGAGGGGTTGAAACCCGCCTCTCGGTATCCATTCCGCTCCAGTAGTGCAAAAGTTACTAGCTTACCTATGAGGGGTTGAAACGAATCCGCCCCTAATTCTTTTGATACAGAGCCGAAAAGTTACTAGCTTACCTATGAGGGGTTGAAACCCGCCTCTCGGTATCCATTCCGCTCCAGTAGTGCAAAGTTACTAGCTTACCTATGAGGGGTTGAAACATACCTCATCCTCGCCAGTCAGATCGTTCCAGAAGGGCGTTACTAGCTTACCTATGAGGGGTTGAAACAGGTATCTGACTATGCTTTCTAATGCTGAGATAACAAGGTTACTAGCTTACCTATGAGGGGTTGAAACGCGATATATTCGCTGTTTTTCTTGAGGAGGAAATATCGTTACTAGCTTACCTATGAGGGGTTGAAACGCGATATATTCGCTGTTTTTCTTGAGGAGGAAATATCGAGTTACTAGCTTACCTATGAGGGGTTGAAACCACCTCGCTCCCGGCGGCACGCATAAGACCACATTTCTGGGTTACTAGCTTACCTATGAGGGGTTGAAACATGGCATCACGATCAAGACCCCGACCGAACTAAAGGTCGTTACTAGCTTACCTATGAGGGGTTGAAACGCGGTTCCCGTAGAAAAATATAGGGAACTCCAATAGCTGTTACTAGCTTACCTATGAGGGGTTGAAACCTTCTCCCCTACTCTCCCCTACCCTACCCTGTTGTGTGTTACTAGCTTACCTATGAGGGGTTGAAACAGATTATTTATTTCTTCCTCAAAGTGATGGTAAAAGTTACTAGCTTACCTATGAGGGGTTGAAACAAGAAATACCTGCACGCAGGTGGACTGCAGAAAGTGCGTTACTAGCTTACCTATGAGGGGTTGAAACTCCGATCGTATGGCGACCAGTTCCTTCGCTCTCTCCCAGTTACTAGCTTACCTATGAGGGGTTGAAACCGATTGGCGGGTCAAGAGAGTATGACAAGAGCAGAAGCGTTACTAGCTTACCTATGAGGGGTTGAAACTTGAAAAAGCTATACGACCGTCCATATAAATACTCGTGTTACTAGCTTACCTATGAGGGGTTGAAACCGATTGGCGGGTCAAGAGAGTATGACAAGAGCAGAAGCGTTACTAGCTTACCTATGAGGGGTTGAAACGAGCAATCGAAACAGCGATAACTGTTGGCGCTCCAGTAGTTACTAGCTTACCTATGAGGGGTTGAAACAGGATGATATCCGGTGATGTTCGGGCACTTACCGGGTTACTAGCTTACCTATGAGGGGTTGAAACTATTTCTCCCGCTCACGCTTGAGGCGTTCGGAAAGAAGTTACTAGCTTACCTATGAGGGGTTGAAACCGGTTATAGTCGGGCTCTCAATCATAGGCGTTGCTAAGTTACTAGCTTACCTATGAGGGGTTGAAACCAAGACAGAGAGCCGAGGAATACACGAGGCGAGCTTGTTACTAGCTTACCTATGAGGGGTTGAAACATCTATTGCTACCGCGTCGATTTCGGCTTCTATTTCTTGTTACTAGCTTACCTATGAGGGGTTGAAACTACATACTCCCCCATGTGTAATGGGATTGGGGAGTATGAGTAGTTACTAGCTTACCTATGAGGGGTTGAAACAATTCTAATCATAGAATAGCATAGATGGAATAAGAAGTTACTAGCTTACCTATGAGGGGTTGAAACCTCGATTTTTTCTTCAATAGCCGCCGAGGCGATGGAATTGTTACTAGCTTACCTATGAGGGGTTGAAACATTCATTCATATTGACACTCTCCTTTCGGTGTTCAAGTTACTAGCTTACCTATGAGGAGTTGAAACCTAAAATGCTTTTCTATTGTTTCGGGTGAATATATGCGGTTACTAGCTTACCTATGAGGGGTTGAAACAGCGGAAGGGCCCGAAGGCCCTGGCCGGGATTCTCGGTTACTAGCTTACCTATGAGGGGTTGAAACTACCCACAAAGGAGGGATTTTACAATACACCCCCGGGTTACTAGCTTACCTATGAGGGGTTGAAACGGGTATGACGAATTTGCAAAAGAATTAGGATTCGATTGTTACTAGCTTACCTATGAGGGGTTGAAACTTTCGTAAACCGATTTAAAAATCCTTCCTTCGCCGCGTTACTAGCTTACCTATGAGGGGTTGAAACTAGGTAATGTATTTGCAACCGCCGCAACCTTTTTCTTTGTTACTAGCTTACCTATGAGGGGTTGAAACAAATTTCCGTTTATGTGAAAATATCTTTTTCGTAAAGTTACTAGCTTACCTATGAGGGGTTGAAACGAGTACTGTTTTTTATTTTTTTAAGGTAGTACTAAAGTTACTAGCTTACCTATGAGGGGTTGAAACCCGCTCCTGAAGTGCCTAATATCGCTGGCGGCGTCGGCGGGTTACTAGCTTACCTATGAGGGGTTGAAACTCGAAGAAAAATAGCCGCCAGCGTCGGCGATTTCAGTTACTAGCTTACCTATGAGGGGTTGAAACCCTTCCTGCCGAGCCGCAAATATTCGGTGCTGGTCTCGTTACTAGCTTACCTATGAGGGGTTGAAACCGGGGACACCGGTCACCCAGGGGCCGTTAGACTTCTTGTTACTAGCTTACCTATGAGGGGTTGAAACACGACATGGAATACAATTTCATCTAAGCTAGGGGATATATGGTTACTAGCTTACCTATGAGGGGTTGAAACTAAGATAGATATGCAGCATCCTCGTATTCTTCGCACATTGTTACTAGCTTACCTATGAGGGGTTGAAACCAGTTAGCGGCGGCACCAGCGGCAGCTTCCTCTTCGTTACTAGCTTACCTATGAGGGGTTGAAACGGGCATGACTCTGGGAGAAAGGGGAGCGTGACACCCCGTTACTAGCTTACCTATGAGGGGTTGAAACGCATATCAGCACTTACGTGAGAGTTCTGAATTAGGCCGTTACTAGCTTACCTATGAGGGGTTGAAACGCGTAAAATACGCACGAGCAAGAACCCGCACGACATTTTCAGTTACTAGCTTACCTATGAGGGGTTGAAACTCATTGAAATAGTCGAAAATTCCGCTGGTATCACACAGTTACTAGCTTACCTATGAGGGGTTGAAACGCTGTAACTGGTGGCTCTTATGTAACTTTCTCAATATGTTACTAGCTTACCTATGAGGGGTTGAAACCCCACTGGTATTTCTATTGCGCCCCGTTTAGGTGGGCGTTACTAGCTTACCTATGAGGGGTTGAAACAAAAAATTTTTGGCATGGCGTCACACTCCCTCCGCTCGTTACTAGCTTACCTATGAGGGGTTGAAACGCAAAATCGTCCAATGTAAGATTATGTTCTTCTCTAAGTTACTAGCTTACCTATGAGGGGTTGAAACGAAAATGACATGATTGAACGGAGTAGAAAGGTAGTCAACGTTACTAGCTTACCTATGAGGGGTTGAAACTCTGCATGACAAAAGCATAGAGTTGCTTTATGTCTGCGTTACTAGCTTACCTATGAGGGGTTGAAACGTGCCTGGAACACTTTTTACCCGTTACTACGGATCATTTAGTTACTAGCTTACCTATGAGGGGTTGAAACTATAAACAAACAGTAGGGTTGGAACGACCCGAATTTAGTTACTAGCTTACCTATGAGGGGTTGAAACTGAGAAAAATAACGATGATTATACTAATAACCCTTTTTGTTACTAGCTTACCTATGAGGGGTTGAAACCGCGTATTACGCCCTCCATAAATTTCATAAGTGGCCAAGGTTACTAGCTTACCTATGAGGGGTTGAAACCTGCTGCCCTCATGAGAGGATGGAATGCCATTCTGAGTTACTAGCTTACCTATGAGGGGTTGAAACCCGTGCTGGCTCCTTCTGCACCGAGGGTTTCACCGACGTTACTAGCTTACCTATGAGGGGTTGAAACCCAGCAAGCTATTCACCGAACGGGAGCGAGGTTTTGGTTACTAGCTTACCTATGAGGGGTTGAAACCCTCCACTTCGCCCGCAAGTATATCGCCATAGTTTAGTTACTAGCTTACCTATGAGGGGTTGAAACTAATGAACCACTGAAAGCGCGAATGCGCCGTAGGTGGTTACTAGCTTACCTATGAGGGGTTGAAACTCTGCATGACAAAAGCATAGAGTTGCTTTATGTCTGCGTTACTAGCTTACCTATGAGGGGTTGAAACGTGCCTGGAACACTTTTTACCCGTTACTACGGATCATTTAGTTACTAGCTTACCTATGAGGGGTTGAAACGCAGAAGCGATGGGCAAAAGCATTGCCGAAGCGAGAGTTACTAGCTTACCTATGAGGGGTTGAAACTGTCGAAAGAATCCAGGGTTTCAAGCCATTTCGGGAAGGTTACTAGCTTACCTATGAGGGGTTGAAACGACAAAATCTCAATTCCAGTATACCACAAAGGAGGAAGTTACTAGCTTACCTATGAGGGGTTGAAAC

>NC_014377|1|1|73465-78146|PILER-CR
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GAGCTGATATAACTGATAATGCTGGTGGAATAGCTGA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CCCCTACTTTAAATTTGTCCGCTATGCTCGCTTTCG
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TCCAGTAACTCCTGTATGACTTTCTTCTTCATATCTCGC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CCGCCTCTCGGTATCCATTCCGCTCCAGTAGTGCAAAA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GAATCCGCCCCTAATTCTTTTGATACAGAGCCGAAAA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CCGCCTCTCGGTATCCATTCCGCTCCAGTAGTGCAAA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	ATACCTCATCCTCGCCAGTCAGATCGTTCCAGAAGGGC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	AGGTATCTGACTATGCTTTCTAATGCTGAGATAACAAG
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GCGATATATTCGCTGTTTTTCTTGAGGAGGAAATATC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GCGATATATTCGCTGTTTTTCTTGAGGAGGAAATATCGA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CACCTCGCTCCCGGCGGCACGCATAAGACCACATTTCTGG
GTTACTAGCTTACCTATGAGGGGTTGAAAC	ATGGCATCACGATCAAGACCCCGACCGAACTAAAGGTC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GCGGTTCCCGTAGAAAAATATAGGGAACTCCAATAGCT
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CTTCTCCCCTACTCTCCCCTACCCTACCCTGTTGTGT
GTTACTAGCTTACCTATGAGGGGTTGAAAC	AGATTATTTATTTCTTCCTCAAAGTGATGGTAAAA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	AAGAAATACCTGCACGCAGGTGGACTGCAGAAAGTGC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TCCGATCGTATGGCGACCAGTTCCTTCGCTCTCTCCCA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CGATTGGCGGGTCAAGAGAGTATGACAAGAGCAGAAGC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TTGAAAAAGCTATACGACCGTCCATATAAATACTCGT
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CGATTGGCGGGTCAAGAGAGTATGACAAGAGCAGAAGC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GAGCAATCGAAACAGCGATAACTGTTGGCGCTCCAGTA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	AGGATGATATCCGGTGATGTTCGGGCACTTACCGG
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TATTTCTCCCGCTCACGCTTGAGGCGTTCGGAAAGAA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CGGTTATAGTCGGGCTCTCAATCATAGGCGTTGCTAA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CAAGACAGAGAGCCGAGGAATACACGAGGCGAGCTT
GTTACTAGCTTACCTATGAGGGGTTGAAAC	ATCTATTGCTACCGCGTCGATTTCGGCTTCTATTTCTT
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TACATACTCCCCCATGTGTAATGGGATTGGGGAGTATGAGTA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	AATTCTAATCATAGAATAGCATAGATGGAATAAGAA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CTCGATTTTTTCTTCAATAGCCGCCGAGGCGATGGAATT
GTTACTAGCTTACCTATGAGGGGTTGAAAC	ATTCATTCATATTGACACTCTCCTTTCGGTGTTCAA
GTTACTAGCTTACCTATGAGGAGTTGAAAC	CTAAAATGCTTTTCTATTGTTTCGGGTGAATATATGCG
GTTACTAGCTTACCTATGAGGGGTTGAAAC	AGCGGAAGGGCCCGAAGGCCCTGGCCGGGATTCTCG
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TACCCACAAAGGAGGGATTTTACAATACACCCCCGG
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GGGTATGACGAATTTGCAAAAGAATTAGGATTCGATT
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TTTCGTAAACCGATTTAAAAATCCTTCCTTCGCCGC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TAGGTAATGTATTTGCAACCGCCGCAACCTTTTTCTTT
GTTACTAGCTTACCTATGAGGGGTTGAAAC	AAATTTCCGTTTATGTGAAAATATCTTTTTCGTAAA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GAGTACTGTTTTTTATTTTTTTAAGGTAGTACTAAA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CCGCTCCTGAAGTGCCTAATATCGCTGGCGGCGTCGGCGG
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TCGAAGAAAAATAGCCGCCAGCGTCGGCGATTTCA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CCTTCCTGCCGAGCCGCAAATATTCGGTGCTGGTCTC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CGGGGACACCGGTCACCCAGGGGCCGTTAGACTTCTT
GTTACTAGCTTACCTATGAGGGGTTGAAAC	ACGACATGGAATACAATTTCATCTAAGCTAGGGGATATATG
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TAAGATAGATATGCAGCATCCTCGTATTCTTCGCACATT
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CAGTTAGCGGCGGCACCAGCGGCAGCTTCCTCTTC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GGGCATGACTCTGGGAGAAAGGGGAGCGTGACACCCC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GCATATCAGCACTTACGTGAGAGTTCTGAATTAGGCC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GCGTAAAATACGCACGAGCAAGAACCCGCACGACATTTTCA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TCATTGAAATAGTCGAAAATTCCGCTGGTATCACACA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GCTGTAACTGGTGGCTCTTATGTAACTTTCTCAATAT
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CCCACTGGTATTTCTATTGCGCCCCGTTTAGGTGGGC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	AAAAAATTTTTGGCATGGCGTCACACTCCCTCCGCTC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GCAAAATCGTCCAATGTAAGATTATGTTCTTCTCTAA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GAAAATGACATGATTGAACGGAGTAGAAAGGTAGTCAAC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TCTGCATGACAAAAGCATAGAGTTGCTTTATGTCTGC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GTGCCTGGAACACTTTTTACCCGTTACTACGGATCATTTA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TATAAACAAACAGTAGGGTTGGAACGACCCGAATTTA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TGAGAAAAATAACGATGATTATACTAATAACCCTTTTT
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CGCGTATTACGCCCTCCATAAATTTCATAAGTGGCCAAG
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CTGCTGCCCTCATGAGAGGATGGAATGCCATTCTGA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CCGTGCTGGCTCCTTCTGCACCGAGGGTTTCACCGAC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CCAGCAAGCTATTCACCGAACGGGAGCGAGGTTTTG
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CCTCCACTTCGCCCGCAAGTATATCGCCATAGTTTA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TAATGAACCACTGAAAGCGCGAATGCGCCGTAGGTG
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TCTGCATGACAAAAGCATAGAGTTGCTTTATGTCTGC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GTGCCTGGAACACTTTTTACCCGTTACTACGGATCATTTA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GCAGAAGCGATGGGCAAAAGCATTGCCGAAGCGAGA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TGTCGAAAGAATCCAGGGTTTCAAGCCATTTCGGGAAG
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GACAAAATCTCAATTCCAGTATACCACAAAGGAGGAA
GTTACTAGCTTACCTATGAGGGGTTGAAAC

>NC_014377|1|1|73465-78146|CRISPRCasFinder
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GAGCTGATATAACTGATAATGCTGGTGGAATAGCTGA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CCCCTACTTTAAATTTGTCCGCTATGCTCGCTTTCG
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TCCAGTAACTCCTGTATGACTTTCTTCTTCATATCTCGC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CCGCCTCTCGGTATCCATTCCGCTCCAGTAGTGCAAAA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GAATCCGCCCCTAATTCTTTTGATACAGAGCCGAAAA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CCGCCTCTCGGTATCCATTCCGCTCCAGTAGTGCAAA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	ATACCTCATCCTCGCCAGTCAGATCGTTCCAGAAGGGC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	AGGTATCTGACTATGCTTTCTAATGCTGAGATAACAAG
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GCGATATATTCGCTGTTTTTCTTGAGGAGGAAATATC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GCGATATATTCGCTGTTTTTCTTGAGGAGGAAATATCGA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CACCTCGCTCCCGGCGGCACGCATAAGACCACATTTCTGG
GTTACTAGCTTACCTATGAGGGGTTGAAAC	ATGGCATCACGATCAAGACCCCGACCGAACTAAAGGTC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GCGGTTCCCGTAGAAAAATATAGGGAACTCCAATAGCT
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CTTCTCCCCTACTCTCCCCTACCCTACCCTGTTGTGT
GTTACTAGCTTACCTATGAGGGGTTGAAAC	AGATTATTTATTTCTTCCTCAAAGTGATGGTAAAA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	AAGAAATACCTGCACGCAGGTGGACTGCAGAAAGTGC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TCCGATCGTATGGCGACCAGTTCCTTCGCTCTCTCCCA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CGATTGGCGGGTCAAGAGAGTATGACAAGAGCAGAAGC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TTGAAAAAGCTATACGACCGTCCATATAAATACTCGT
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CGATTGGCGGGTCAAGAGAGTATGACAAGAGCAGAAGC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GAGCAATCGAAACAGCGATAACTGTTGGCGCTCCAGTA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	AGGATGATATCCGGTGATGTTCGGGCACTTACCGG
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TATTTCTCCCGCTCACGCTTGAGGCGTTCGGAAAGAA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CGGTTATAGTCGGGCTCTCAATCATAGGCGTTGCTAA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CAAGACAGAGAGCCGAGGAATACACGAGGCGAGCTT
GTTACTAGCTTACCTATGAGGGGTTGAAAC	ATCTATTGCTACCGCGTCGATTTCGGCTTCTATTTCTT
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TACATACTCCCCCATGTGTAATGGGATTGGGGAGTATGAGTA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	AATTCTAATCATAGAATAGCATAGATGGAATAAGAA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CTCGATTTTTTCTTCAATAGCCGCCGAGGCGATGGAATT
GTTACTAGCTTACCTATGAGGGGTTGAAAC	ATTCATTCATATTGACACTCTCCTTTCGGTGTTCAA
GTTACTAGCTTACCTATGAGGAGTTGAAAC	CTAAAATGCTTTTCTATTGTTTCGGGTGAATATATGCG
GTTACTAGCTTACCTATGAGGGGTTGAAAC	AGCGGAAGGGCCCGAAGGCCCTGGCCGGGATTCTCG
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TACCCACAAAGGAGGGATTTTACAATACACCCCCGG
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GGGTATGACGAATTTGCAAAAGAATTAGGATTCGATT
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TTTCGTAAACCGATTTAAAAATCCTTCCTTCGCCGC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TAGGTAATGTATTTGCAACCGCCGCAACCTTTTTCTTT
GTTACTAGCTTACCTATGAGGGGTTGAAAC	AAATTTCCGTTTATGTGAAAATATCTTTTTCGTAAA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GAGTACTGTTTTTTATTTTTTTAAGGTAGTACTAAA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CCGCTCCTGAAGTGCCTAATATCGCTGGCGGCGTCGGCGG
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TCGAAGAAAAATAGCCGCCAGCGTCGGCGATTTCA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CCTTCCTGCCGAGCCGCAAATATTCGGTGCTGGTCTC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CGGGGACACCGGTCACCCAGGGGCCGTTAGACTTCTT
GTTACTAGCTTACCTATGAGGGGTTGAAAC	ACGACATGGAATACAATTTCATCTAAGCTAGGGGATATATG
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TAAGATAGATATGCAGCATCCTCGTATTCTTCGCACATT
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CAGTTAGCGGCGGCACCAGCGGCAGCTTCCTCTTC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GGGCATGACTCTGGGAGAAAGGGGAGCGTGACACCCC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GCATATCAGCACTTACGTGAGAGTTCTGAATTAGGCC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GCGTAAAATACGCACGAGCAAGAACCCGCACGACATTTTCA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TCATTGAAATAGTCGAAAATTCCGCTGGTATCACACA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GCTGTAACTGGTGGCTCTTATGTAACTTTCTCAATAT
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CCCACTGGTATTTCTATTGCGCCCCGTTTAGGTGGGC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	AAAAAATTTTTGGCATGGCGTCACACTCCCTCCGCTC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GCAAAATCGTCCAATGTAAGATTATGTTCTTCTCTAA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GAAAATGACATGATTGAACGGAGTAGAAAGGTAGTCAAC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TCTGCATGACAAAAGCATAGAGTTGCTTTATGTCTGC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GTGCCTGGAACACTTTTTACCCGTTACTACGGATCATTTA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TATAAACAAACAGTAGGGTTGGAACGACCCGAATTTA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TGAGAAAAATAACGATGATTATACTAATAACCCTTTTT
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CGCGTATTACGCCCTCCATAAATTTCATAAGTGGCCAAG
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CTGCTGCCCTCATGAGAGGATGGAATGCCATTCTGA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CCGTGCTGGCTCCTTCTGCACCGAGGGTTTCACCGAC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CCAGCAAGCTATTCACCGAACGGGAGCGAGGTTTTG
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CCTCCACTTCGCCCGCAAGTATATCGCCATAGTTTA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TAATGAACCACTGAAAGCGCGAATGCGCCGTAGGTG
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TCTGCATGACAAAAGCATAGAGTTGCTTTATGTCTGC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GTGCCTGGAACACTTTTTACCCGTTACTACGGATCATTTA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GCAGAAGCGATGGGCAAAAGCATTGCCGAAGCGAGA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TGTCGAAAGAATCCAGGGTTTCAAGCCATTTCGGGAAG
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GACAAAATCTCAATTCCAGTATACCACAAAGGAGGAA
GTTACTAGCTTACCTATGAGGGGTTGAAAC

>NC_014377|1|1|73465-78146|CRT
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GAGCTGATATAACTGATAATGCTGGTGGAATAGCTGA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CCCCTACTTTAAATTTGTCCGCTATGCTCGCTTTCG
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TCCAGTAACTCCTGTATGACTTTCTTCTTCATATCTCGC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CCGCCTCTCGGTATCCATTCCGCTCCAGTAGTGCAAAA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GAATCCGCCCCTAATTCTTTTGATACAGAGCCGAAAA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CCGCCTCTCGGTATCCATTCCGCTCCAGTAGTGCAAA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	ATACCTCATCCTCGCCAGTCAGATCGTTCCAGAAGGGC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	AGGTATCTGACTATGCTTTCTAATGCTGAGATAACAAG
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GCGATATATTCGCTGTTTTTCTTGAGGAGGAAATATC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GCGATATATTCGCTGTTTTTCTTGAGGAGGAAATATCGA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CACCTCGCTCCCGGCGGCACGCATAAGACCACATTTCTGG
GTTACTAGCTTACCTATGAGGGGTTGAAAC	ATGGCATCACGATCAAGACCCCGACCGAACTAAAGGTC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GCGGTTCCCGTAGAAAAATATAGGGAACTCCAATAGCT
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CTTCTCCCCTACTCTCCCCTACCCTACCCTGTTGTGT
GTTACTAGCTTACCTATGAGGGGTTGAAAC	AGATTATTTATTTCTTCCTCAAAGTGATGGTAAAA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	AAGAAATACCTGCACGCAGGTGGACTGCAGAAAGTGC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TCCGATCGTATGGCGACCAGTTCCTTCGCTCTCTCCCA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CGATTGGCGGGTCAAGAGAGTATGACAAGAGCAGAAGC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TTGAAAAAGCTATACGACCGTCCATATAAATACTCGT
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CGATTGGCGGGTCAAGAGAGTATGACAAGAGCAGAAGC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GAGCAATCGAAACAGCGATAACTGTTGGCGCTCCAGTA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	AGGATGATATCCGGTGATGTTCGGGCACTTACCGG
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TATTTCTCCCGCTCACGCTTGAGGCGTTCGGAAAGAA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CGGTTATAGTCGGGCTCTCAATCATAGGCGTTGCTAA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CAAGACAGAGAGCCGAGGAATACACGAGGCGAGCTT
GTTACTAGCTTACCTATGAGGGGTTGAAAC	ATCTATTGCTACCGCGTCGATTTCGGCTTCTATTTCTT
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TACATACTCCCCCATGTGTAATGGGATTGGGGAGTATGAGTA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	AATTCTAATCATAGAATAGCATAGATGGAATAAGAA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CTCGATTTTTTCTTCAATAGCCGCCGAGGCGATGGAATT
GTTACTAGCTTACCTATGAGGGGTTGAAAC	ATTCATTCATATTGACACTCTCCTTTCGGTGTTCAA
GTTACTAGCTTACCTATGAGGAGTTGAAAC	CTAAAATGCTTTTCTATTGTTTCGGGTGAATATATGCG
GTTACTAGCTTACCTATGAGGGGTTGAAAC	AGCGGAAGGGCCCGAAGGCCCTGGCCGGGATTCTCG
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TACCCACAAAGGAGGGATTTTACAATACACCCCCGG
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GGGTATGACGAATTTGCAAAAGAATTAGGATTCGATT
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TTTCGTAAACCGATTTAAAAATCCTTCCTTCGCCGC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TAGGTAATGTATTTGCAACCGCCGCAACCTTTTTCTTT
GTTACTAGCTTACCTATGAGGGGTTGAAAC	AAATTTCCGTTTATGTGAAAATATCTTTTTCGTAAA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GAGTACTGTTTTTTATTTTTTTAAGGTAGTACTAAA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CCGCTCCTGAAGTGCCTAATATCGCTGGCGGCGTCGGCGG
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TCGAAGAAAAATAGCCGCCAGCGTCGGCGATTTCA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CCTTCCTGCCGAGCCGCAAATATTCGGTGCTGGTCTC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CGGGGACACCGGTCACCCAGGGGCCGTTAGACTTCTT
GTTACTAGCTTACCTATGAGGGGTTGAAAC	ACGACATGGAATACAATTTCATCTAAGCTAGGGGATATATG
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TAAGATAGATATGCAGCATCCTCGTATTCTTCGCACATT
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CAGTTAGCGGCGGCACCAGCGGCAGCTTCCTCTTC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GGGCATGACTCTGGGAGAAAGGGGAGCGTGACACCCC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GCATATCAGCACTTACGTGAGAGTTCTGAATTAGGCC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GCGTAAAATACGCACGAGCAAGAACCCGCACGACATTTTCA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TCATTGAAATAGTCGAAAATTCCGCTGGTATCACACA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GCTGTAACTGGTGGCTCTTATGTAACTTTCTCAATAT
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CCCACTGGTATTTCTATTGCGCCCCGTTTAGGTGGGC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	AAAAAATTTTTGGCATGGCGTCACACTCCCTCCGCTC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GCAAAATCGTCCAATGTAAGATTATGTTCTTCTCTAA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GAAAATGACATGATTGAACGGAGTAGAAAGGTAGTCAAC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TCTGCATGACAAAAGCATAGAGTTGCTTTATGTCTGC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GTGCCTGGAACACTTTTTACCCGTTACTACGGATCATTTA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TATAAACAAACAGTAGGGTTGGAACGACCCGAATTTA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TGAGAAAAATAACGATGATTATACTAATAACCCTTTTT
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CGCGTATTACGCCCTCCATAAATTTCATAAGTGGCCAAG
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CTGCTGCCCTCATGAGAGGATGGAATGCCATTCTGA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CCGTGCTGGCTCCTTCTGCACCGAGGGTTTCACCGAC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CCAGCAAGCTATTCACCGAACGGGAGCGAGGTTTTG
GTTACTAGCTTACCTATGAGGGGTTGAAAC	CCTCCACTTCGCCCGCAAGTATATCGCCATAGTTTA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TAATGAACCACTGAAAGCGCGAATGCGCCGTAGGTG
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TCTGCATGACAAAAGCATAGAGTTGCTTTATGTCTGC
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GTGCCTGGAACACTTTTTACCCGTTACTACGGATCATTTA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GCAGAAGCGATGGGCAAAAGCATTGCCGAAGCGAGA
GTTACTAGCTTACCTATGAGGGGTTGAAAC	TGTCGAAAGAATCCAGGGTTTCAAGCCATTTCGGGAAG
GTTACTAGCTTACCTATGAGGGGTTGAAAC	GACAAAATCTCAATTCCAGTATACCACAAAGGAGGAA
GTTACTAGCTTACCTATGAGGGGTTGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_014377.1\|WP_049817869.1\|81557_82370_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	gnl\|CDD\|224499
NC_014377.1\|WP_148218347.1\|66148_67267_+\|hypothetical-protein	cas8b1	mkCas0074_cas8b1_CAS-I-B	unknown
NC_014377.1\|WP_041423970.1\|86798_87344_+\|YeeE/YedE-family-protein	unknown	unknown	gnl\|CDD\|236845
NC_014377.1\|WP_013274931.1\|90023_90980_+\|sulfurtransferase	unknown	unknown	gnl\|CDD\|225450
NC_014377.1\|WP_013274926.1\|84876_85107_+\|sulfurtransferase-TusA-family-protein	unknown	unknown	gnl\|CDD\|376492
NC_014377.1\|WP_013274917.1\|68972_71408_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|224124
NC_014377.1\|WP_041423802.1\|65207_66233_+\|hypothetical-protein	cas8b1	mkCas0074_cas8b1_CAS-I-B	unknown
NC_014377.1\|WP_013274922.1\|79807_81028_-\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376564
NC_014377.1\|WP_013274919.1\|72004_72997_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|274695
NC_014377.1\|WP_013274916.1\|68280_68979_+\|CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	gnl\|CDD\|131641
NC_014377.1\|WP_013274925.1\|83248_84472_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376564
NC_014377.1\|WP_013274920.1\|73018_73282_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NC_014377.1\|WP_013274924.1\|82599_82935_-\|hypothetical-protein	unknown	unknown	unknown
NC_014377.1\|WP_041423804.1\|71445_71952_+\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
NC_014377.1\|WP_013274915.1\|67291_68242_+\|type-I-CRISPR-associated-protein-Cas7	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	gnl\|CDD\|377458
NC_014377.1\|WP_013274930.1\|87454_90004_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|237198
NC_014377.1\|WP_049817870.1\|86171_86765_+\|YeeE/YedE-family-protein	unknown	unknown	gnl\|CDD\|236845
NC_014377.1\|WP_148218425.1\|63752_64292_+\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl\|CDD\|153251
NC_014377.1\|WP_013274914.1\|64412_65168_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	gnl\|CDD\|224499
NC_014377.1\|WP_013274927.1\|85103_86006_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176112

Protein	Function_ID	Function_description	E-value
NC_014377.1\|WP_049817869.1\|81557_82370_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|224499	COG1583, COG1583, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	3.17281e-46
NC_014377.1\|WP_013274930.1\|87454_90004_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|237198	PRK12771, PRK12771, putative glutamate synthase (NADPH) small subunit; Provisional.	3.07958e-147
NC_014377.1\|WP_041423970.1\|86798_87344_+\|YeeE/YedE-family-protein	gnl\|CDD\|236845	PRK11099, PRK11099, putative inner membrane protein; Provisional.	1.79836e-31
NC_014377.1\|WP_013274931.1\|90023_90980_+\|sulfurtransferase	gnl\|CDD\|225450	COG2897, SseA, Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism].	2.65264e-90
NC_014377.1\|WP_013274917.1\|68972_71408_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	5.6939e-43
NC_014377.1\|WP_013274915.1\|67291_68242_+\|type-I-CRISPR-associated-protein-Cas7	gnl\|CDD\|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	5.27764e-73
NC_014377.1\|WP_013274916.1\|68280_68979_+\|CRISPR-associated-protein-Cas5	gnl\|CDD\|131641	TIGR02592, hypothetical_protein_CTC_01466, CRISPR-associated protein Cas5, subtype I-B/HMARI. This is a CRISPR-associated protein unique to the hmari subtype of cas genes and CRISPR repeat, which is the only subtype present in Haloarcula marismortui ATCC 43049. The hmari type, though uncommon, is also found in the Aquificae, Thermotogae, Firmicutes, and Dictyoglomi.	5.86683e-19
NC_014377.1\|WP_013274919.1\|72004_72997_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274695	TIGR03641, cas1_HMARI, CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes Cas1 subgroup that includes Cas1 proteins of the related HMARI and TNEAP subtypes of CRISPR/Cas system.	1.44216e-167
NC_014377.1\|WP_013274922.1\|79807_81028_-\|IS110-family-transposase	gnl\|CDD\|376564	pfam01548, DEDD_Tnp_IS110, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family includes an amino-terminal region of the pilin gene inverting protein (PIVML) and of members of the IS111A/IS1328/IS1533 family of transposases. The C-terminus is represented by family pfam02371.	1.32318e-43
NC_014377.1\|WP_013274926.1\|84876_85107_+\|sulfurtransferase-TusA-family-protein	gnl\|CDD\|376492	pfam01206, TusA, Sulfurtransferase TusA. This family includes the TusA sulfurtransferases.	6.27212e-12
NC_014377.1\|WP_013274920.1\|73018_73282_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	3.24487e-31
NC_014377.1\|WP_041423804.1\|71445_71952_+\|CRISPR-associated-protein-Cas4	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	6.41605e-72
NC_014377.1\|WP_013274925.1\|83248_84472_+\|IS110-family-transposase	gnl\|CDD\|376564	pfam01548, DEDD_Tnp_IS110, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family includes an amino-terminal region of the pilin gene inverting protein (PIVML) and of members of the IS111A/IS1328/IS1533 family of transposases. The C-terminus is represented by family pfam02371.	6.47027e-47
NC_014377.1\|WP_049817870.1\|86171_86765_+\|YeeE/YedE-family-protein	gnl\|CDD\|236845	PRK11099, PRK11099, putative inner membrane protein; Provisional.	2.39974e-23
NC_014377.1\|WP_148218425.1\|63752_64292_+\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl\|CDD\|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	7.0576e-51
NC_014377.1\|WP_013274914.1\|64412_65168_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|224499	COG1583, COG1583, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	8.34765e-35
NC_014377.1\|WP_013274927.1\|85103_86006_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176112	cd08420, PBP2_CysL_like, C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold. CysL, also known as YwfK, is a regular of sulfur metabolism in Bacillus subtilis. Sulfur is required for the synthesis of proteins and essential cofactors in all living organism. Sulfur can be assimilated either from inorganic sources (sulfate and thiosulfate), or from organic sources (sulfate esters, sulfamates, and sulfonates). CysL activates the transcription of the cysJI operon encoding sulfite reductase, which reduces sulfite to sulfide. Both cysL mutant and cysJI mutant are unable to grow using sulfate or sulfite as the sulfur source. Like other LysR-type regulators, CysL also negatively regulates its own transcription. In Escherichia coli, three LysR-type activators are involved in the regulation of sulfur metabolism: CysB, Cbl and MetR. The topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	5.0031e-74

>NC_014377.1|WP_013274920.1|73018_73282_+|CRISPR-associated-endonuclease-Cas2
MFIILVYDVGEKRVAKVLKICRKYLTWVQNSVFEGEITESAYKKLKLELKRAIVEDEDSVIFYILRTIKYSDREMLGRKKGGEEIFL
>NC_014377.1|WP_013274919.1|72004_72997_+|type-I-B-CRISPR-associated-endonuclease-Cas1
MKKAIYIFSSGELKRKDNTLYLETEDRKNYIPVENTSEIYIFGEVNINKRFLEFASQNQIIIHFFNHYDYYVGSFYPREFLNSGYMILKQAEYYLDKEKRLTIAREFVRGAVKNILQVIRYYINRGKDLVKIDERIRELEGRIDDFNEIDELMAIEGNIRECYYSSFDKILQNQDFKFCKRTTRPPKNNLNSLISFGNSMIYTIVLSEIYKTHLDPRIGFLHATNFRRFTLNLDVAEIFKPIIVDRVILTLIGRKVITKDDFEQDSEGLIIKEKAKREFIKELEEKLSTTFKHRQIGKNVSYRRLIRLELYKLEKHLMGEQEYSAFVAGW
>NC_014377.1|WP_041423804.1|71445_71952_+|CRISPR-associated-protein-Cas4
MLNEEINITGTLVWYYFICPRQVWLMSHNINPDEDDENVAIGRFLHQESYARERKEISFHGGKVDVLGTREGQLVIAEIKKSSKAERSAKMQLAFYLFELRKLGIEAKGELRYLEEKRKEQIVLDEQLTREVENAITRILKLMYEPVPPKPEKIRWCSNCAYREFCWA
>NC_014377.1|WP_013274917.1|68972_71408_+|CRISPR-associated-helicase/endonuclease-Cas3
MVIPFRECVARPKSGDGNPNLLTDHLFAVAKFMGDPKGGDESRLRFLAGLCHDVGKATKRWQMYILSKEEGRVVASGGSHSPLGSMIFFVCSEQLVTKDLPRRFREYLITQLTLDIAGHHGSIKNIDPAWPPWEEALLSAEGVYPYETVDLDGFFDFVREYFPEITLTSRSFADRLQGIDRRWAVVADKALGYAKRYIDNSADRDSAAAGLIMRDRTSAMISADRFHAAGLNFAFFHPEEARVAINNLAEECSRLQKNAAPETLRIVKLRNDHQKEALETYRTFPDRLIYSLELATGLGKTLTALRIALEAVASGKCSRVIYVAPYISILSQATNVIREATGISDIIEHHHLSFLDIDYEHLRSEEDGAFLIDSWQSKIVTTTFNQFFLALFPTKAQHTVRIQALNNAFVIIDEPQIIEPKAWAAFLKTLEAAAKRLHFQSILCTATLPHASDYLNEEYMCLSRGDSLIPRYIIKTLEGKWDAQTLAELAVKKLMEKGSVAVILNTVADAARVYMAVKDLILRGYFENITGIDIFNLTGCMTPLHKSAWISRIKDSLRRGKKCIVVCTQILEAGVDLSFRCVIRARPVIPSVIQAAGRGNRHGEGDPAEVLVVDFVRDDGEDSRKYVYKNPIFREVTDEQLEICKEFSEKDSREIIENFYREAFKRNPPTRKMQLIYEAAMGQWSRLKEIEPFEGDYPKVMVFVPRVFKGSGGPDIPEIIQRAMKYFGISGVSDIYQRYLEKGFWKSLSFRDKKLFMALIEQFCVCVSVKRADSIVRIPEGAFIGSLVDDRIYSEDTGMALAEDSTEFRMF
>NC_014377.1|WP_013274916.1|68280_68979_+|CRISPR-associated-protein-Cas5
MKLLVFELRGDIAHFRRPDGIVTHPTYPAMPRTVLCGLIASILGKSVLDGENWMGYSILSPVRTVTQEMSMLGKGWMGNSGDYFNRLTSIQLIVNPHYRVYYAGDHFETLVEMIRERRSVFHTYLGSAFCLTFPRFTGVIDAEEISPAPGDILTAITIVPTNIVERLITETGERYIPMRGARYTVDRDRNFKGTLNFIIEESGRPIKFRTRDSAGSVNYRILKVENGVICLW
>NC_014377.1|WP_013274915.1|67291_68242_+|type-I-CRISPR-associated-protein-Cas7
MPEIPRTGEILFIKCVKDGIPNRDPLNDSDARRIFGEDDGRISLSDVSIKRDVRDYIQHRFPDGGPDKKYHIFVRQEKGENGKLRDRKELARKIIEDVSGEDSPDKKKTLMSAAFDVRVFGAVYSVEKESFNQTGPVQFGWAHSLHPVETRYVQGTVVIPSEDASKGQGSIWTTYIVPFAVFCMPGVINQSIANETGATRDDIELLLEALWKGTLHRQARGRGIQQPCFLLHVEYSDPFFRIGYLEDYISLEPGREAWLGGNPPTSLEQVRLNVDRLAEVLDPNGEFGNKIERIRYWVNPALTISCELPGTREKIW
>NC_014377.1|WP_148218347.1|66148_67267_+|hypothetical-protein
MAYKRLFAPVDSPGGRENKKAGDASVKVTGCVYPAPVDMALSEEDMKFLGEEISLMVSREHAAGRRVRDIQSVVGFESQISEENLQDALRFYIVYYSGDRSKGDVHLRATMEDVLPSILIKLDDVAKSTVMSVAELSRELPGSKNEDLYGQIRSRYGSIPWLLANAYGPGYMWQTLEKVITRKKLDQGSFVTGCGHRMLTLSRSWPDSKWKIFDEVLFFYGFASFLSIYHSTLGIEGGMCKLSDWKELRKLVVETPAEDMVLDTVEKVGFAAGYVIQEFSRRYYAVKAKDFIKHRVMVFGSSLSPDVIWSRGLARLEEYAKNLDIYMEPELSKKNAVTMLAYNRLRDKIKAEKDLFIASFWSGYALSAKTSD
>NC_014377.1|WP_041423802.1|65207_66233_+|hypothetical-protein
MLVDSLIRLGKVLMSFPHSPRAIVKEISALGDPLAGDFLQRIYIVEVYRNPEPKIVCSPTICWGDFEDAGGKKSKKSIFRPDFERAIGTPFFLPQGGNRRQPQGYYPVPVYIVYDEDFKEFSENPEKVVRFLKGRFARTEGAALTGDELMVCAESISRSIRETNISEKRNLKALIAICIIDEDSPYRLKPSGVKIDERIEFKVTESFAYPGMAVYTDLTKILDRLWKAKLTEGAEAGKIDNGICVTCGKIDKLVSIYNKSWPLFLPTWSCPLPQLSAKKKLNLAEKTGGLCEDCYKALTYGASAFRSMEKDIPGWLTKGYSLLLTALVEGKIKKRGTRRSK
>NC_014377.1|WP_013274914.1|64412_65168_+|CRISPR-associated-endoribonuclease-Cas6
MRVRIHFEPVTLGTSIYYPYYLQTALYSLLDGELGTWMHDKGLVLEKRRLKPICFSRLMGEYKLDRERGIIYFPKGAALVVTSPISEICQSLLTGLLKRGEIILGKSSFPVSKVEIADPKVSGSSILVRTLSPITVYSTMLKFDGSKYTCYFSPKDSEFVSLCRDNLVRKARALGWEENQDFELNIEFKGDPKTNMVKFKNNFIKGYSGYLMISGPTRYLKLALDWGLGAKNSAGFGCLEITGGGNHQDRI
>NC_014377.1|WP_148218425.1|63752_64292_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MSNVPKKGPLIIVSNHQSILDPTVLMACISRRIHFLAAAYLFRIPVLNILLPMAGAIPVKSEKGDLASFKKALRILAKGGVIALFPEGGVSPDGSLRPFKHGWAYLALKSGAPVLPVAVIGTRDVLPVGTYMPRRGRIEVRVGECVAVQKKGRVRQEDFGELNMMMEGRLKSLLVGTRQ
>NC_014377.1|WP_013274922.1|79807_81028_-|IS110-family-transposase
MDVVYSHVCGLDVHKKSVVACVITPDGKEIRSFSTMTDDLIALKEFIKNKGCTVVAMESTGSFWKPIYNLLELENINILLVNAKHIKNVPGRKTDVKDAEWIASLLRHGLLKGSFVPDREQRELRELVRYRHSLVEERSRELNRIQKVLEGANIKLSSVVSDINGMSSHSILEALISGVDDPEILAELSHGKLKNKKEDLKRALKGFINYHQRKMLEIQLRHIDYLDEEIERLDEEIKNRMLPFEEDLALLDTIPGVGRRNAEQIIAEIGTNMDQFPSAAHLCSWAGLCPGQNESAGKRKSARTRKGNKKLRSALVEAARAASRAKDTYLSSQYHRIAARRGSNRAAVAVANSILTIVYHILKRRQPYIELGPNFYEEKRRNMVIRQSLKKLESLGLKVTVETMVS
>NC_014377.1|WP_049817869.1|81557_82370_+|CRISPR-associated-endoribonuclease-Cas6
MSKKESTIAGGGLMRMKLTFNSESPVALPIHYNHIIQGMIYSNLTQEFAEFMHEDGFPWGKRRFKLFTFSRLEGKFRMVEGGRIEFEPPFSFIVSSPLERFLRELAGGLLKNDDLSLAGRRVVLENVTVHAAVEDHDLGDRIKINMLSPVVAYKTLVEGGKKRTLYLTPLQEEFGELLKNNLLKKYAVLTGQEPGERKFEIKPAFPLSEKHCKIIKYKDVIIKGWMGVYTLRGDPALLKIAYDAGLGSKNSQGFGCFEILEGLKRRSGAI
>NC_014377.1|WP_013274924.1|82599_82935_-|hypothetical-protein
MNLKQKLDELCTWVGIVGWVTTIAGAIEAIIGLFAYVIGALPGVITLILGIKLLGARKYAKSIALSQEYNEQDMVLLIKELTAYFKIQGLFIIIGFSAAIIVALSGFLLYQ
>NC_014377.1|WP_013274925.1|83248_84472_+|IS110-family-transposase
MFYGGIDVAKHSHEVCLVNDSGDIVLKMHLDNNHKGMNKLLQALERLGLKPDDVKFCLEATGHYWLPIYCYLTNQGFELHVINPIQSDALRNLYVRKTKTDQKDALLLADLLRLGRAPETRLPSETTLKLQSLSRLRFEFVRQVGGLKNRVLGILDRIFPEYPDCFSDVFIRTSRELLKSYPEPEELAEVDLSELSAFLKEHSRGRFGEERAKKIQSLAKGTFGITMALDAFTLQLRLLVEQIEFIEEQIKVIEDAINEVMEELRPSKDTPYRHVIETIPGIGPVLAAAIIGEIGDISRFPNPRALVAYAGLDATVRASGLFEGTRNRMSKRGSPVLRNSLWLAAVSARRFNPELRAYYEQKRSQGKHSNVATGAVARKLVHLIYSLWKDNRPYDPDYQWSPPGKNA
>NC_014377.1|WP_013274926.1|84876_85107_+|sulfurtransferase-TusA-family-protein
MTEYLIDSLGDMCPVPNLKVQAKIKKLRPGDRIVILTDHSCAVTTIVDEMKRKRLKTKVEEVENGVWRVVISMAAR
>NC_014377.1|WP_013274927.1|85103_86006_-|LysR-family-transcriptional-regulator
MNINLLKSFIAIAETQSLSRAAERLFVTQPALSQQIKQLENHFSVQLIERTNRGILLTEAGRILYDYASRIVSIYEDLEKNMEDFRASISGTLIVGASSIVGGYAVPCSIFIFKEKYPETNIKLKVGNRKYILEELRDGAIDVAIIEGEKPIGNFVSSEIASDEMVVIAPNREPWNGKDTLSPEEFLSQPIIMREDGSGTRQMIEKCLMQAGIDKSRLNIVMELSSADSIKAAVEAGHGISIMPRLAVRKELYNKTLVALKIEGVPLVQKIHLAYKREKVKSQAAKAFIKFMHTPNRGFC
>NC_014377.1|WP_049817870.1|86171_86765_+|YeeE/YedE-family-protein
MALLLTLVIFGIYLSRAGKILTVRWIFGIAFGFVLQRSRFCFTAAVRDPILTGNTSLFRAVIIAIAVAMVGFSSIQFAAHLSGYPVPGMIKPAGVHTLLGGIIFGIGAVLSGGCASGTLMRVGEGHLLNLIALVFFIAGSAAGAYHFGWFKEHIIKSARPVFLPDLMGWGAAFFGQLALLFILYRLALWWDYKSRAQ
>NC_014377.1|WP_041423970.1|86798_87344_+|YeeE/YedE-family-protein
MEFYKEKLKRFADVILKEPFPYWFGAIVLGILNVCLLAVSGEPWRITSYFAHWGAWVARAFGARPEFWAFYGERENAAALADGFLRDGGSVQNLGIIAGAMLAALLASQFRFRKIKSYKQVIGAVIGGFLMGYGARLSFGCNIGALFSGISSMSLHGWIFMAGMLAGAYLGSRLLIKFFLY
>NC_014377.1|WP_013274930.1|87454_90004_+|FAD-dependent-oxidoreductase
MYPAEVLEKMKEIVDNCMGDAPAYCVATCPMHTDARGYIKLISEGRYKEAIKLIREKLFLPATLGRICAHPCEQKCKRNEVGHQPMSIAALKRFAAEYDDPSDWDLSMEPEKDIKIAVIGSGPAGAQAAIDLRRKGYKVTIFEKLPVAGGMLRVGIPEYRLPRDILEKEYSYLTKLGIEIRLNTEVGKDVAFGDIRDNYDAVLIAVGAHRSVMLPVPGIDLKGVIPAVDFLREVSMTRKYPVGKRVAVIGGGNVAMDVARSLIRVGAKKVDVFCLEKREQMPAHSWEVEEAEEEGVVIHNGWGPKEIVGEDGKVKKIVFKACESVFDKEGRFNPCYDESKLYEIEADNVVLAVGQTADSSFLADTGIELLKNGKVKADPVTLETSLKGVFAAGDAVGRPLFAIEAMAEGRKAAVSIDRYLKGEDLRAGREFEGAYETWLEKDVSAEQFLPRVQTMKLSPEERIKGFMEVDLGFTEEMARKEAERCLQCECRLCVKECLMLQDFTHCPKELFKEILDTGKVNPLVPYSCNMCNKCTLECPKEFRLADRFSEIRKELVKQGIGPLKQHRPILMHQKFSFSRIFNVTLPDKKAGFTRRIFYPGCSLPSYNPEAVGRIYEYLKEKLPGTGAILKCCGKPTKALGQEELFKQRSAMVVEEVRRLGAEEVITACQSCYKTLSEYLPKHIPGIKVRSLWVVLKEIGLPEKARGIAKNSGMTVAIHDSCVTRDVPEIHDAVRFIVSELGYGIEELPNSRGNTRCCGYGGMVVPANPELAKRVMQRRANEAKCEYIATYCAACRASMVMGGKKGLHLLDLIFGGDWRGKETPGVDSTLQSWSKRWKTKKILTRIANKK
>NC_014377.1|WP_013274931.1|90023_90980_+|sulfurtransferase
MRKIVALALILLLAVSLAACSQQKSATAPAKFLTGKEKGYANPEAIITPQELKELIDKNAVKIIDARPEDRYAKEHIPGAVRAWRNEYNDPTHKYEGMRATPEQFAQLMSKLGIANGDLVVVYGDAEKHSPADAARVWWLFKLYGDNKVRILDGGIEAWKAAGFETTKELPQVTETKYEVKVDTSLLAEVEDVLAGQNNPDVIILDTREEAEFLGKQKVKGAARAGRIPGAVWLYWGDALNEDKTLKSYDELKKLYEEKGVTPDKTVIPYCQSAVRSAHATFVMTELLGYKNVKNYDGSWVEWSQRTDLPIETGEPKN

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Crispr_ID: NC_014377_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014377_2

79548-79646

TypeI-B

Consensus_repeat	Method
GTTACTAGCTTACCTATGAGGGGTTGAAACAT	CRISPRCasFinder

1 spacers

cas2,cas1,cas4,cas3,cas5,cas7b,cas8b1,cas6

The CRISPR arrays of NC_014377_2

>merge|NC_014377|2|79548-79646|CRISPRCasFinder
GTTACTAGCTTACCTATGAGGGGTTGAAACATAATATCCCTATCAGTATACATTTCAGGGAGTTCTAGTTACTAGCTTACCTATGAGGGGTTGAAACAT

>NC_014377|2|2|79548-79646|CRISPRCasFinder
GTTACTAGCTTACCTATGAGGGGTTGAAACAT	AATATCCCTATCAGTATACATTTCAGGGAGTTCTA
GTTACTAGCTTACCTATGAGGGGTTGAAACAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_014377.1\|WP_049817869.1\|81557_82370_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	gnl\|CDD\|224499
NC_014377.1\|WP_148218347.1\|66148_67267_+\|hypothetical-protein	cas8b1	mkCas0074_cas8b1_CAS-I-B	unknown
NC_014377.1\|WP_041423970.1\|86798_87344_+\|YeeE/YedE-family-protein	unknown	unknown	gnl\|CDD\|236845
NC_014377.1\|WP_013274931.1\|90023_90980_+\|sulfurtransferase	unknown	unknown	gnl\|CDD\|225450
NC_014377.1\|WP_013274926.1\|84876_85107_+\|sulfurtransferase-TusA-family-protein	unknown	unknown	gnl\|CDD\|376492
NC_014377.1\|WP_013274917.1\|68972_71408_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|224124
NC_014377.1\|WP_041423802.1\|65207_66233_+\|hypothetical-protein	cas8b1	mkCas0074_cas8b1_CAS-I-B	unknown
NC_014377.1\|WP_013274922.1\|79807_81028_-\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376564
NC_014377.1\|WP_013274919.1\|72004_72997_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|274695
NC_014377.1\|WP_013274916.1\|68280_68979_+\|CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	gnl\|CDD\|131641
NC_014377.1\|WP_013274925.1\|83248_84472_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376564
NC_014377.1\|WP_013274920.1\|73018_73282_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NC_014377.1\|WP_013274924.1\|82599_82935_-\|hypothetical-protein	unknown	unknown	unknown
NC_014377.1\|WP_041423804.1\|71445_71952_+\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
NC_014377.1\|WP_013274915.1\|67291_68242_+\|type-I-CRISPR-associated-protein-Cas7	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	gnl\|CDD\|377458
NC_014377.1\|WP_013274930.1\|87454_90004_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|237198
NC_014377.1\|WP_049817870.1\|86171_86765_+\|YeeE/YedE-family-protein	unknown	unknown	gnl\|CDD\|236845
NC_014377.1\|WP_148218425.1\|63752_64292_+\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl\|CDD\|153251
NC_014377.1\|WP_013274914.1\|64412_65168_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	gnl\|CDD\|224499
NC_014377.1\|WP_013274927.1\|85103_86006_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176112

Protein	Function_ID	Function_description	E-value
NC_014377.1\|WP_049817869.1\|81557_82370_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|224499	COG1583, COG1583, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	3.17281e-46
NC_014377.1\|WP_013274930.1\|87454_90004_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|237198	PRK12771, PRK12771, putative glutamate synthase (NADPH) small subunit; Provisional.	3.07958e-147
NC_014377.1\|WP_041423970.1\|86798_87344_+\|YeeE/YedE-family-protein	gnl\|CDD\|236845	PRK11099, PRK11099, putative inner membrane protein; Provisional.	1.79836e-31
NC_014377.1\|WP_013274931.1\|90023_90980_+\|sulfurtransferase	gnl\|CDD\|225450	COG2897, SseA, Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism].	2.65264e-90
NC_014377.1\|WP_013274917.1\|68972_71408_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	5.6939e-43
NC_014377.1\|WP_013274915.1\|67291_68242_+\|type-I-CRISPR-associated-protein-Cas7	gnl\|CDD\|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	5.27764e-73
NC_014377.1\|WP_013274916.1\|68280_68979_+\|CRISPR-associated-protein-Cas5	gnl\|CDD\|131641	TIGR02592, hypothetical_protein_CTC_01466, CRISPR-associated protein Cas5, subtype I-B/HMARI. This is a CRISPR-associated protein unique to the hmari subtype of cas genes and CRISPR repeat, which is the only subtype present in Haloarcula marismortui ATCC 43049. The hmari type, though uncommon, is also found in the Aquificae, Thermotogae, Firmicutes, and Dictyoglomi.	5.86683e-19
NC_014377.1\|WP_013274919.1\|72004_72997_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274695	TIGR03641, cas1_HMARI, CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes Cas1 subgroup that includes Cas1 proteins of the related HMARI and TNEAP subtypes of CRISPR/Cas system.	1.44216e-167
NC_014377.1\|WP_013274922.1\|79807_81028_-\|IS110-family-transposase	gnl\|CDD\|376564	pfam01548, DEDD_Tnp_IS110, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family includes an amino-terminal region of the pilin gene inverting protein (PIVML) and of members of the IS111A/IS1328/IS1533 family of transposases. The C-terminus is represented by family pfam02371.	1.32318e-43
NC_014377.1\|WP_013274926.1\|84876_85107_+\|sulfurtransferase-TusA-family-protein	gnl\|CDD\|376492	pfam01206, TusA, Sulfurtransferase TusA. This family includes the TusA sulfurtransferases.	6.27212e-12
NC_014377.1\|WP_013274920.1\|73018_73282_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	3.24487e-31
NC_014377.1\|WP_041423804.1\|71445_71952_+\|CRISPR-associated-protein-Cas4	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	6.41605e-72
NC_014377.1\|WP_013274925.1\|83248_84472_+\|IS110-family-transposase	gnl\|CDD\|376564	pfam01548, DEDD_Tnp_IS110, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family includes an amino-terminal region of the pilin gene inverting protein (PIVML) and of members of the IS111A/IS1328/IS1533 family of transposases. The C-terminus is represented by family pfam02371.	6.47027e-47
NC_014377.1\|WP_049817870.1\|86171_86765_+\|YeeE/YedE-family-protein	gnl\|CDD\|236845	PRK11099, PRK11099, putative inner membrane protein; Provisional.	2.39974e-23
NC_014377.1\|WP_148218425.1\|63752_64292_+\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl\|CDD\|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	7.0576e-51
NC_014377.1\|WP_013274914.1\|64412_65168_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|224499	COG1583, COG1583, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	8.34765e-35
NC_014377.1\|WP_013274927.1\|85103_86006_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176112	cd08420, PBP2_CysL_like, C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold. CysL, also known as YwfK, is a regular of sulfur metabolism in Bacillus subtilis. Sulfur is required for the synthesis of proteins and essential cofactors in all living organism. Sulfur can be assimilated either from inorganic sources (sulfate and thiosulfate), or from organic sources (sulfate esters, sulfamates, and sulfonates). CysL activates the transcription of the cysJI operon encoding sulfite reductase, which reduces sulfite to sulfide. Both cysL mutant and cysJI mutant are unable to grow using sulfate or sulfite as the sulfur source. Like other LysR-type regulators, CysL also negatively regulates its own transcription. In Escherichia coli, three LysR-type activators are involved in the regulation of sulfur metabolism: CysB, Cbl and MetR. The topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	5.0031e-74

>NC_014377.1|WP_013274920.1|73018_73282_+|CRISPR-associated-endonuclease-Cas2
MFIILVYDVGEKRVAKVLKICRKYLTWVQNSVFEGEITESAYKKLKLELKRAIVEDEDSVIFYILRTIKYSDREMLGRKKGGEEIFL
>NC_014377.1|WP_013274919.1|72004_72997_+|type-I-B-CRISPR-associated-endonuclease-Cas1
MKKAIYIFSSGELKRKDNTLYLETEDRKNYIPVENTSEIYIFGEVNINKRFLEFASQNQIIIHFFNHYDYYVGSFYPREFLNSGYMILKQAEYYLDKEKRLTIAREFVRGAVKNILQVIRYYINRGKDLVKIDERIRELEGRIDDFNEIDELMAIEGNIRECYYSSFDKILQNQDFKFCKRTTRPPKNNLNSLISFGNSMIYTIVLSEIYKTHLDPRIGFLHATNFRRFTLNLDVAEIFKPIIVDRVILTLIGRKVITKDDFEQDSEGLIIKEKAKREFIKELEEKLSTTFKHRQIGKNVSYRRLIRLELYKLEKHLMGEQEYSAFVAGW
>NC_014377.1|WP_041423804.1|71445_71952_+|CRISPR-associated-protein-Cas4
MLNEEINITGTLVWYYFICPRQVWLMSHNINPDEDDENVAIGRFLHQESYARERKEISFHGGKVDVLGTREGQLVIAEIKKSSKAERSAKMQLAFYLFELRKLGIEAKGELRYLEEKRKEQIVLDEQLTREVENAITRILKLMYEPVPPKPEKIRWCSNCAYREFCWA
>NC_014377.1|WP_013274917.1|68972_71408_+|CRISPR-associated-helicase/endonuclease-Cas3
MVIPFRECVARPKSGDGNPNLLTDHLFAVAKFMGDPKGGDESRLRFLAGLCHDVGKATKRWQMYILSKEEGRVVASGGSHSPLGSMIFFVCSEQLVTKDLPRRFREYLITQLTLDIAGHHGSIKNIDPAWPPWEEALLSAEGVYPYETVDLDGFFDFVREYFPEITLTSRSFADRLQGIDRRWAVVADKALGYAKRYIDNSADRDSAAAGLIMRDRTSAMISADRFHAAGLNFAFFHPEEARVAINNLAEECSRLQKNAAPETLRIVKLRNDHQKEALETYRTFPDRLIYSLELATGLGKTLTALRIALEAVASGKCSRVIYVAPYISILSQATNVIREATGISDIIEHHHLSFLDIDYEHLRSEEDGAFLIDSWQSKIVTTTFNQFFLALFPTKAQHTVRIQALNNAFVIIDEPQIIEPKAWAAFLKTLEAAAKRLHFQSILCTATLPHASDYLNEEYMCLSRGDSLIPRYIIKTLEGKWDAQTLAELAVKKLMEKGSVAVILNTVADAARVYMAVKDLILRGYFENITGIDIFNLTGCMTPLHKSAWISRIKDSLRRGKKCIVVCTQILEAGVDLSFRCVIRARPVIPSVIQAAGRGNRHGEGDPAEVLVVDFVRDDGEDSRKYVYKNPIFREVTDEQLEICKEFSEKDSREIIENFYREAFKRNPPTRKMQLIYEAAMGQWSRLKEIEPFEGDYPKVMVFVPRVFKGSGGPDIPEIIQRAMKYFGISGVSDIYQRYLEKGFWKSLSFRDKKLFMALIEQFCVCVSVKRADSIVRIPEGAFIGSLVDDRIYSEDTGMALAEDSTEFRMF
>NC_014377.1|WP_013274916.1|68280_68979_+|CRISPR-associated-protein-Cas5
MKLLVFELRGDIAHFRRPDGIVTHPTYPAMPRTVLCGLIASILGKSVLDGENWMGYSILSPVRTVTQEMSMLGKGWMGNSGDYFNRLTSIQLIVNPHYRVYYAGDHFETLVEMIRERRSVFHTYLGSAFCLTFPRFTGVIDAEEISPAPGDILTAITIVPTNIVERLITETGERYIPMRGARYTVDRDRNFKGTLNFIIEESGRPIKFRTRDSAGSVNYRILKVENGVICLW
>NC_014377.1|WP_013274915.1|67291_68242_+|type-I-CRISPR-associated-protein-Cas7
MPEIPRTGEILFIKCVKDGIPNRDPLNDSDARRIFGEDDGRISLSDVSIKRDVRDYIQHRFPDGGPDKKYHIFVRQEKGENGKLRDRKELARKIIEDVSGEDSPDKKKTLMSAAFDVRVFGAVYSVEKESFNQTGPVQFGWAHSLHPVETRYVQGTVVIPSEDASKGQGSIWTTYIVPFAVFCMPGVINQSIANETGATRDDIELLLEALWKGTLHRQARGRGIQQPCFLLHVEYSDPFFRIGYLEDYISLEPGREAWLGGNPPTSLEQVRLNVDRLAEVLDPNGEFGNKIERIRYWVNPALTISCELPGTREKIW
>NC_014377.1|WP_148218347.1|66148_67267_+|hypothetical-protein
MAYKRLFAPVDSPGGRENKKAGDASVKVTGCVYPAPVDMALSEEDMKFLGEEISLMVSREHAAGRRVRDIQSVVGFESQISEENLQDALRFYIVYYSGDRSKGDVHLRATMEDVLPSILIKLDDVAKSTVMSVAELSRELPGSKNEDLYGQIRSRYGSIPWLLANAYGPGYMWQTLEKVITRKKLDQGSFVTGCGHRMLTLSRSWPDSKWKIFDEVLFFYGFASFLSIYHSTLGIEGGMCKLSDWKELRKLVVETPAEDMVLDTVEKVGFAAGYVIQEFSRRYYAVKAKDFIKHRVMVFGSSLSPDVIWSRGLARLEEYAKNLDIYMEPELSKKNAVTMLAYNRLRDKIKAEKDLFIASFWSGYALSAKTSD
>NC_014377.1|WP_041423802.1|65207_66233_+|hypothetical-protein
MLVDSLIRLGKVLMSFPHSPRAIVKEISALGDPLAGDFLQRIYIVEVYRNPEPKIVCSPTICWGDFEDAGGKKSKKSIFRPDFERAIGTPFFLPQGGNRRQPQGYYPVPVYIVYDEDFKEFSENPEKVVRFLKGRFARTEGAALTGDELMVCAESISRSIRETNISEKRNLKALIAICIIDEDSPYRLKPSGVKIDERIEFKVTESFAYPGMAVYTDLTKILDRLWKAKLTEGAEAGKIDNGICVTCGKIDKLVSIYNKSWPLFLPTWSCPLPQLSAKKKLNLAEKTGGLCEDCYKALTYGASAFRSMEKDIPGWLTKGYSLLLTALVEGKIKKRGTRRSK
>NC_014377.1|WP_013274914.1|64412_65168_+|CRISPR-associated-endoribonuclease-Cas6
MRVRIHFEPVTLGTSIYYPYYLQTALYSLLDGELGTWMHDKGLVLEKRRLKPICFSRLMGEYKLDRERGIIYFPKGAALVVTSPISEICQSLLTGLLKRGEIILGKSSFPVSKVEIADPKVSGSSILVRTLSPITVYSTMLKFDGSKYTCYFSPKDSEFVSLCRDNLVRKARALGWEENQDFELNIEFKGDPKTNMVKFKNNFIKGYSGYLMISGPTRYLKLALDWGLGAKNSAGFGCLEITGGGNHQDRI
>NC_014377.1|WP_148218425.1|63752_64292_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MSNVPKKGPLIIVSNHQSILDPTVLMACISRRIHFLAAAYLFRIPVLNILLPMAGAIPVKSEKGDLASFKKALRILAKGGVIALFPEGGVSPDGSLRPFKHGWAYLALKSGAPVLPVAVIGTRDVLPVGTYMPRRGRIEVRVGECVAVQKKGRVRQEDFGELNMMMEGRLKSLLVGTRQ
>NC_014377.1|WP_013274922.1|79807_81028_-|IS110-family-transposase
MDVVYSHVCGLDVHKKSVVACVITPDGKEIRSFSTMTDDLIALKEFIKNKGCTVVAMESTGSFWKPIYNLLELENINILLVNAKHIKNVPGRKTDVKDAEWIASLLRHGLLKGSFVPDREQRELRELVRYRHSLVEERSRELNRIQKVLEGANIKLSSVVSDINGMSSHSILEALISGVDDPEILAELSHGKLKNKKEDLKRALKGFINYHQRKMLEIQLRHIDYLDEEIERLDEEIKNRMLPFEEDLALLDTIPGVGRRNAEQIIAEIGTNMDQFPSAAHLCSWAGLCPGQNESAGKRKSARTRKGNKKLRSALVEAARAASRAKDTYLSSQYHRIAARRGSNRAAVAVANSILTIVYHILKRRQPYIELGPNFYEEKRRNMVIRQSLKKLESLGLKVTVETMVS
>NC_014377.1|WP_049817869.1|81557_82370_+|CRISPR-associated-endoribonuclease-Cas6
MSKKESTIAGGGLMRMKLTFNSESPVALPIHYNHIIQGMIYSNLTQEFAEFMHEDGFPWGKRRFKLFTFSRLEGKFRMVEGGRIEFEPPFSFIVSSPLERFLRELAGGLLKNDDLSLAGRRVVLENVTVHAAVEDHDLGDRIKINMLSPVVAYKTLVEGGKKRTLYLTPLQEEFGELLKNNLLKKYAVLTGQEPGERKFEIKPAFPLSEKHCKIIKYKDVIIKGWMGVYTLRGDPALLKIAYDAGLGSKNSQGFGCFEILEGLKRRSGAI
>NC_014377.1|WP_013274924.1|82599_82935_-|hypothetical-protein
MNLKQKLDELCTWVGIVGWVTTIAGAIEAIIGLFAYVIGALPGVITLILGIKLLGARKYAKSIALSQEYNEQDMVLLIKELTAYFKIQGLFIIIGFSAAIIVALSGFLLYQ
>NC_014377.1|WP_013274925.1|83248_84472_+|IS110-family-transposase
MFYGGIDVAKHSHEVCLVNDSGDIVLKMHLDNNHKGMNKLLQALERLGLKPDDVKFCLEATGHYWLPIYCYLTNQGFELHVINPIQSDALRNLYVRKTKTDQKDALLLADLLRLGRAPETRLPSETTLKLQSLSRLRFEFVRQVGGLKNRVLGILDRIFPEYPDCFSDVFIRTSRELLKSYPEPEELAEVDLSELSAFLKEHSRGRFGEERAKKIQSLAKGTFGITMALDAFTLQLRLLVEQIEFIEEQIKVIEDAINEVMEELRPSKDTPYRHVIETIPGIGPVLAAAIIGEIGDISRFPNPRALVAYAGLDATVRASGLFEGTRNRMSKRGSPVLRNSLWLAAVSARRFNPELRAYYEQKRSQGKHSNVATGAVARKLVHLIYSLWKDNRPYDPDYQWSPPGKNA
>NC_014377.1|WP_013274926.1|84876_85107_+|sulfurtransferase-TusA-family-protein
MTEYLIDSLGDMCPVPNLKVQAKIKKLRPGDRIVILTDHSCAVTTIVDEMKRKRLKTKVEEVENGVWRVVISMAAR
>NC_014377.1|WP_013274927.1|85103_86006_-|LysR-family-transcriptional-regulator
MNINLLKSFIAIAETQSLSRAAERLFVTQPALSQQIKQLENHFSVQLIERTNRGILLTEAGRILYDYASRIVSIYEDLEKNMEDFRASISGTLIVGASSIVGGYAVPCSIFIFKEKYPETNIKLKVGNRKYILEELRDGAIDVAIIEGEKPIGNFVSSEIASDEMVVIAPNREPWNGKDTLSPEEFLSQPIIMREDGSGTRQMIEKCLMQAGIDKSRLNIVMELSSADSIKAAVEAGHGISIMPRLAVRKELYNKTLVALKIEGVPLVQKIHLAYKREKVKSQAAKAFIKFMHTPNRGFC
>NC_014377.1|WP_049817870.1|86171_86765_+|YeeE/YedE-family-protein
MALLLTLVIFGIYLSRAGKILTVRWIFGIAFGFVLQRSRFCFTAAVRDPILTGNTSLFRAVIIAIAVAMVGFSSIQFAAHLSGYPVPGMIKPAGVHTLLGGIIFGIGAVLSGGCASGTLMRVGEGHLLNLIALVFFIAGSAAGAYHFGWFKEHIIKSARPVFLPDLMGWGAAFFGQLALLFILYRLALWWDYKSRAQ
>NC_014377.1|WP_041423970.1|86798_87344_+|YeeE/YedE-family-protein
MEFYKEKLKRFADVILKEPFPYWFGAIVLGILNVCLLAVSGEPWRITSYFAHWGAWVARAFGARPEFWAFYGERENAAALADGFLRDGGSVQNLGIIAGAMLAALLASQFRFRKIKSYKQVIGAVIGGFLMGYGARLSFGCNIGALFSGISSMSLHGWIFMAGMLAGAYLGSRLLIKFFLY
>NC_014377.1|WP_013274930.1|87454_90004_+|FAD-dependent-oxidoreductase
MYPAEVLEKMKEIVDNCMGDAPAYCVATCPMHTDARGYIKLISEGRYKEAIKLIREKLFLPATLGRICAHPCEQKCKRNEVGHQPMSIAALKRFAAEYDDPSDWDLSMEPEKDIKIAVIGSGPAGAQAAIDLRRKGYKVTIFEKLPVAGGMLRVGIPEYRLPRDILEKEYSYLTKLGIEIRLNTEVGKDVAFGDIRDNYDAVLIAVGAHRSVMLPVPGIDLKGVIPAVDFLREVSMTRKYPVGKRVAVIGGGNVAMDVARSLIRVGAKKVDVFCLEKREQMPAHSWEVEEAEEEGVVIHNGWGPKEIVGEDGKVKKIVFKACESVFDKEGRFNPCYDESKLYEIEADNVVLAVGQTADSSFLADTGIELLKNGKVKADPVTLETSLKGVFAAGDAVGRPLFAIEAMAEGRKAAVSIDRYLKGEDLRAGREFEGAYETWLEKDVSAEQFLPRVQTMKLSPEERIKGFMEVDLGFTEEMARKEAERCLQCECRLCVKECLMLQDFTHCPKELFKEILDTGKVNPLVPYSCNMCNKCTLECPKEFRLADRFSEIRKELVKQGIGPLKQHRPILMHQKFSFSRIFNVTLPDKKAGFTRRIFYPGCSLPSYNPEAVGRIYEYLKEKLPGTGAILKCCGKPTKALGQEELFKQRSAMVVEEVRRLGAEEVITACQSCYKTLSEYLPKHIPGIKVRSLWVVLKEIGLPEKARGIAKNSGMTVAIHDSCVTRDVPEIHDAVRFIVSELGYGIEELPNSRGNTRCCGYGGMVVPANPELAKRVMQRRANEAKCEYIATYCAACRASMVMGGKKGLHLLDLIFGGDWRGKETPGVDSTLQSWSKRWKTKKILTRIANKK
>NC_014377.1|WP_013274931.1|90023_90980_+|sulfurtransferase
MRKIVALALILLLAVSLAACSQQKSATAPAKFLTGKEKGYANPEAIITPQELKELIDKNAVKIIDARPEDRYAKEHIPGAVRAWRNEYNDPTHKYEGMRATPEQFAQLMSKLGIANGDLVVVYGDAEKHSPADAARVWWLFKLYGDNKVRILDGGIEAWKAAGFETTKELPQVTETKYEVKVDTSLLAEVEDVLAGQNNPDVIILDTREEAEFLGKQKVKGAARAGRIPGAVWLYWGDALNEDKTLKSYDELKKLYEEKGVTPDKTVIPYCQSAVRSAHATFVMTELLGYKNVKNYDGSWVEWSQRTDLPIETGEPKN

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Crispr_ID: NC_014377_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014377_3

526446-529224

TypeIII

Consensus_repeat	Method
GTTTTTAGCTTACCTATGAGGGATTGAAAC	PILER-CR
GTTTTTAGCTTACCTATGAGGGATTGAAAC	CRISPRCasFinder
GTTTTTAGCTTACCTATGAGGGATTGAAAC	CRT

41 spacers

cas10,csm2gr11,csm3gr7,csm4gr5,csm5gr7

The CRISPR arrays of NC_014377_3

>merge|NC_014377|3|526446-529224|PILER-CR,CRISPRCasFinder,CRT
GTTTTTAGCTTACCTATGAGGGATTGAAACGGGGATCTTCCATGGCGTAAAATAAAAAATACTGAAGAGTTTTTAGCTTACCTATGAGGGATTGAAACCCCGTCCGTAGCAACCGGAATATACTTCAGTCGAATGTTTTTAGCTTACCTATGAGGGATTGAAACCAGGTATATCGAGCCCTGCAAAAGCGGCAGTGATCAGTTTTTAGCTTACCTATGAGGGATTGAAACAAACTGGAAAGCTCGTCTATTATCACCATATCAAAAGTTTTTAGCTTACCTATGAGGGATTGAAACCGGCATCCGGATCAATCTCATCGAAGGTTACCGATACTGGGTTTTTAGCTTACCTATGAGGGATTGAAACATTGGATGCTGCGTATCCGCAGTCCACTCCGCTACGTTTTTAGCTTACCTATGAGGGATTGAAACATTCCGTGTTAGTAAGGTGTTTCTCGTATATCTCGTCGTTTTTAGCTTACCTATGAGGGATTGAAACCCAGCTTGGACGGCTCCTGGGTGCTGGACGGCACCGTTTTTAGCTTACCTATGAGGGATTGAAACATTTAGTTACGGTGCGGACAAAGACACATTTTTTATGTTTTTAGCTTACCTATGAGGGATTGAAACATTAGTTCTCCGTCTACCGTTTCGAGGTCCCGAACTTCGTTTTTAGCTTACCTATGAGGGATTGAAACCCGAAAGAAAAAGATTGAGTGTAAATTAAATGAACTTGTTTTTAGCTTACCTATGAGGGATTGAAACAATATATTCCATATTAGACGCAAAAACCACCTTTCAGTTTTTAGCTTACCTATGAGGGATTGAAACTCTACCTGTTTAATCATTGATATAACGGGAGCTACTCCGTTTTTAGCTTACCTATGAGGGATTGAAACTGCCACAATTGCCGGCTCAGTTTATCCTCTCTCTCGTTTTTAGCTTACCTATGAGGGATTGAAACGGGTATCGTACACAGTTTTACTGTTCCGCCGTATATAGGTTTTTAGCTTACCTATGAGGGATTGAAACCATAGTCCGGGCCATAGCAGAGACCACAAACTACGAGTTTTTAGCTTACCTATGAGGGATTGAAACTGCTTAAGGATAGGCTTAAAGAACTACGCAATAAAAAAGTTTTTAGCTTACCTATGAGGGATTGAAACTAGACAATTTATACGCGTCCTATGTTATAGCCTTCTGTGTTTTTAGCTTACCTATGAGGGATTGAAACATACGCCACATCACGCAAGAATAAAAATCGAAAATAAGTTTTTAGCTTACCTATGAGGATTGAAACATATACTTCAGGCTATGGGGACAATGCCAACGACGTGGTTTTTAGCTTACCTATGAGGGATTGAAACTAGGCTTGTCCCTCCTACATAGATTCTTGTCTTTATTGTTTTTAGCTTACCTATGAGGGATTGAAACTCAGGCAAGAATATTCACCGCTAACCAAAGGATACTTCATGTTTTTAGCTTACCTATGAGGGATTGAAACGACCATCTATAACACTAAAACCTTGCTGGCTGCTATGTTTTTAGCTTACCTATGAGGGATTGAAACGCGCCAAGAATCTCCGAAGTAGTGCGCCGTATTGGTCCTGTTTTTAGCTTACCTATGAGGGATTGAAACTTGGATGAGCCTATGACTGTGGCTCATGCCAGGCTGAGTTTTTAGCTTACCTATGAGGGATTGAAACGCCCCTCCCATCAGATGGAACCGGTTCGTGCCGTTTGTTTTTAGCTTACCTATGAGGGATTGAAACATCTTCCGGTTCTTAATTTTGCCGTATCCACACCCGAGTTTTTAGCTTACCTATGAGGGATTGAAACTTCAACAGTAGTCTTTTTTCTGCCTCCACCAAACAAAGTTTTTAGCTTACCTATGAGGGATTGAAACCGCTCTCGACAACCGACACCAGCGTGACGCCCGTCCTGGTTTTTAGCTTACCTATGAGGGATTGAAACGGCTATCCAATTGTCCCTCGCCAGGCAGGAAACCAAAAGTTTTTAGCTTACCTATGAGGGATTGAAACAAGCTACGTATAGAAATTACCTCGACTAAAATTATAGATGTTTTTAGCTTACCTATGAGGGATTGAAACTCTACTCCATCGCCAACAACATGGATCTGCCCGGTGAGTTTTTAGCTTACCTATGAGGGATTGAAACACCAATCGAACAATGACAAAAGGGAAATCCGGATCGGGTTTTTAGCTTACCTATGAGGGATTGAAACAGGAAAAAGCAATTGAAATTTGCGACTTTATTAGGGAGGTTTTTAGCTTACCTATGAGGGATTGAAACTTATACAGTTTGTCATTACGACCGCACGCATAGGCGGCGTTTTTAGCTTACCTATGAGGGATTGAAACAAAAGGCCGACACTCTGGCACATAGCCAGAAATGTCGTTTTTAGCTTACCTATGAGGGATTGAAACTAGGAAAAGTCTTATTAGAAAAGGAGGCATAATATGGGTTTTTAGCTTACCTATGAGGGATTGAAACCCTAATAGATTATTTAGTATGTTTTTTATCTCTCCTGTTTTTAGCTTACCTATGAGGGATTGAAACGAGGTTTTCCGCCTTCGTTAAGGAGCTCCTGGAAGAGTTTTTAGCTTACCTATGAGGGATTGAAACTCGCCAAGGCCCATCTCCTCGAACGTGGGCTTCCACGTTTTTAGCTTACCTATGAGGGATTGAAACTGGCCCTGTCCCACACCTGTTCTTTTCGTGCGATCCATGTTTTTAGCTTACCTATCCTGAAAATAATG

>NC_014377|3|2|526446-529156|PILER-CR
GTTTTTAGCTTACCTATGAGGGATTGAAAC	GGGGATCTTCCATGGCGTAAAATAAAAAATACTGAAGA
GTTTTTAGCTTACCTATGAGGGATTGAAAC	CCCGTCCGTAGCAACCGGAATATACTTCAGTCGAAT
GTTTTTAGCTTACCTATGAGGGATTGAAAC	CAGGTATATCGAGCCCTGCAAAAGCGGCAGTGATCA
GTTTTTAGCTTACCTATGAGGGATTGAAAC	AAACTGGAAAGCTCGTCTATTATCACCATATCAAAA
GTTTTTAGCTTACCTATGAGGGATTGAAAC	CGGCATCCGGATCAATCTCATCGAAGGTTACCGATACTGG
GTTTTTAGCTTACCTATGAGGGATTGAAAC	ATTGGATGCTGCGTATCCGCAGTCCACTCCGCTAC
GTTTTTAGCTTACCTATGAGGGATTGAAAC	ATTCCGTGTTAGTAAGGTGTTTCTCGTATATCTCGTC
GTTTTTAGCTTACCTATGAGGGATTGAAAC	CCAGCTTGGACGGCTCCTGGGTGCTGGACGGCACC
GTTTTTAGCTTACCTATGAGGGATTGAAAC	ATTTAGTTACGGTGCGGACAAAGACACATTTTTTAT
GTTTTTAGCTTACCTATGAGGGATTGAAAC	ATTAGTTCTCCGTCTACCGTTTCGAGGTCCCGAACTTC
GTTTTTAGCTTACCTATGAGGGATTGAAAC	CCGAAAGAAAAAGATTGAGTGTAAATTAAATGAACTT
GTTTTTAGCTTACCTATGAGGGATTGAAAC	AATATATTCCATATTAGACGCAAAAACCACCTTTCA
GTTTTTAGCTTACCTATGAGGGATTGAAAC	TCTACCTGTTTAATCATTGATATAACGGGAGCTACTCC
GTTTTTAGCTTACCTATGAGGGATTGAAAC	TGCCACAATTGCCGGCTCAGTTTATCCTCTCTCTC
GTTTTTAGCTTACCTATGAGGGATTGAAAC	GGGTATCGTACACAGTTTTACTGTTCCGCCGTATATAG
GTTTTTAGCTTACCTATGAGGGATTGAAAC	CATAGTCCGGGCCATAGCAGAGACCACAAACTACGA
GTTTTTAGCTTACCTATGAGGGATTGAAAC	TGCTTAAGGATAGGCTTAAAGAACTACGCAATAAAAAA
GTTTTTAGCTTACCTATGAGGGATTGAAAC	TAGACAATTTATACGCGTCCTATGTTATAGCCTTCTGT
GTTTTTAGCTTACCTATGAGGGATTGAAAC	ATACGCCACATCACGCAAGAATAAAAATCGAAAATAA
GTTTTTAGCTTACCTATGAGGATTGAAACA	TATACTTCAGGCTATGGGGACAATGCCAACGACGTGGTTTTTAGC
TTACCTATGAGGGATTGAAACTAGGCTTGT	CCCTCCTACATAGATTCTTGTCTTTATTGTTTTTAGC
TTACCTATGAGGGATTGAAACTCAGGCAAG	AATATTCACCGCTAACCAAAGGATACTTCATGTTTTTAGC
TTACCTATGAGGGATTGAAACGACCATCTA	TAACACTAAAACCTTGCTGGCTGCTATGTTTTTAGC
TTACCTATGAGGGATTGAAACGCGCCAAGA	ATCTCCGAAGTAGTGCGCCGTATTGGTCCTGTTTTTAGC
TTACCTATGAGGGATTGAAACTTGGATGAG	CCTATGACTGTGGCTCATGCCAGGCTGAGTTTTTAGC
TTACCTATGAGGGATTGAAACGCCCCTCCC	ATCAGATGGAACCGGTTCGTGCCGTTTGTTTTTAGC
TTACCTATGAGGGATTGAAACATCTTCCGG	TTCTTAATTTTGCCGTATCCACACCCGAGTTTTTAGC
TTACCTATGAGGGATTGAAACTTCAACAGT	AGTCTTTTTTCTGCCTCCACCAAACAAAGTTTTTAGC
TTACCTATGAGGGATTGAAACCGCTCTCGA	CAACCGACACCAGCGTGACGCCCGTCCTGGTTTTTAGC
TTACCTATGAGGGATTGAAACGGCTATCCA	ATTGTCCCTCGCCAGGCAGGAAACCAAAAGTTTTTAGC
TTACCTATGAGGGATTGAAACAAGCTACGT	ATAGAAATTACCTCGACTAAAATTATAGATGTTTTTAGC
TTACCTATGAGGGATTGAAACTCTACTCCA	TCGCCAACAACATGGATCTGCCCGGTGAGTTTTTAGC
TTACCTATGAGGGATTGAAACACCAATCGA	ACAATGACAAAAGGGAAATCCGGATCGGGTTTTTAGC
TTACCTATGAGGGATTGAAACAGGAAAAAG	CAATTGAAATTTGCGACTTTATTAGGGAGGTTTTTAGC
TTACCTATGAGGGATTGAAACTTATACAGT	TTGTCATTACGACCGCACGCATAGGCGGCGTTTTTAGC
TTACCTATGAGGGATTGAAACAAAAGGCCG	ACACTCTGGCACATAGCCAGAAATGTCGTTTTTAGC
TTACCTATGAGGGATTGAAACTAGGAAAAG	TCTTATTAGAAAAGGAGGCATAATATGGGTTTTTAGC
TTACCTATGAGGGATTGAAACCCTAATAGA	TTATTTAGTATGTTTTTTATCTCTCCTGTTTTTAGC
TTACCTATGAGGGATTGAAACGAGGTTTTC	CGCCTTCGTTAAGGAGCTCCTGGAAGAGTTTTTAGC
TTACCTATGAGGGATTGAAACTCGCCAAGG	CCCATCTCCTCGAACGTGGGCTTCCACGTTTTTAGC
TTACCTATGAGGGATTGAAAC

>NC_014377|3|3|526446-529224|CRISPRCasFinder
GTTTTTAGCTTACCTATGAGGGATTGAAAC	GGGGATCTTCCATGGCGTAAAATAAAAAATACTGAAGA
GTTTTTAGCTTACCTATGAGGGATTGAAAC	CCCGTCCGTAGCAACCGGAATATACTTCAGTCGAAT
GTTTTTAGCTTACCTATGAGGGATTGAAAC	CAGGTATATCGAGCCCTGCAAAAGCGGCAGTGATCA
GTTTTTAGCTTACCTATGAGGGATTGAAAC	AAACTGGAAAGCTCGTCTATTATCACCATATCAAAA
GTTTTTAGCTTACCTATGAGGGATTGAAAC	CGGCATCCGGATCAATCTCATCGAAGGTTACCGATACTGG
GTTTTTAGCTTACCTATGAGGGATTGAAAC	ATTGGATGCTGCGTATCCGCAGTCCACTCCGCTAC
GTTTTTAGCTTACCTATGAGGGATTGAAAC	ATTCCGTGTTAGTAAGGTGTTTCTCGTATATCTCGTC
GTTTTTAGCTTACCTATGAGGGATTGAAAC	CCAGCTTGGACGGCTCCTGGGTGCTGGACGGCACC
GTTTTTAGCTTACCTATGAGGGATTGAAAC	ATTTAGTTACGGTGCGGACAAAGACACATTTTTTAT
GTTTTTAGCTTACCTATGAGGGATTGAAAC	ATTAGTTCTCCGTCTACCGTTTCGAGGTCCCGAACTTC
GTTTTTAGCTTACCTATGAGGGATTGAAAC	CCGAAAGAAAAAGATTGAGTGTAAATTAAATGAACTT
GTTTTTAGCTTACCTATGAGGGATTGAAAC	AATATATTCCATATTAGACGCAAAAACCACCTTTCA
GTTTTTAGCTTACCTATGAGGGATTGAAAC	TCTACCTGTTTAATCATTGATATAACGGGAGCTACTCC
GTTTTTAGCTTACCTATGAGGGATTGAAAC	TGCCACAATTGCCGGCTCAGTTTATCCTCTCTCTC
GTTTTTAGCTTACCTATGAGGGATTGAAAC	GGGTATCGTACACAGTTTTACTGTTCCGCCGTATATAG
GTTTTTAGCTTACCTATGAGGGATTGAAAC	CATAGTCCGGGCCATAGCAGAGACCACAAACTACGA
GTTTTTAGCTTACCTATGAGGGATTGAAAC	TGCTTAAGGATAGGCTTAAAGAACTACGCAATAAAAAA
GTTTTTAGCTTACCTATGAGGGATTGAAAC	TAGACAATTTATACGCGTCCTATGTTATAGCCTTCTGT
GTTTTTAGCTTACCTATGAGGGATTGAAAC	ATACGCCACATCACGCAAGAATAAAAATCGAAAATAA
GTTTTTAGCTTACCTATGAGGATTGAAACA	TATACTTCAGGCTATGGGGACAATGCCAACGACGTG
GTTTTTAGCTTACCTATGAGGGATTGAAAC	TAGGCTTGTCCCTCCTACATAGATTCTTGTCTTTATT
GTTTTTAGCTTACCTATGAGGGATTGAAAC	TCAGGCAAGAATATTCACCGCTAACCAAAGGATACTTCAT
GTTTTTAGCTTACCTATGAGGGATTGAAAC	GACCATCTATAACACTAAAACCTTGCTGGCTGCTAT
GTTTTTAGCTTACCTATGAGGGATTGAAAC	GCGCCAAGAATCTCCGAAGTAGTGCGCCGTATTGGTCCT
GTTTTTAGCTTACCTATGAGGGATTGAAAC	TTGGATGAGCCTATGACTGTGGCTCATGCCAGGCTGA
GTTTTTAGCTTACCTATGAGGGATTGAAAC	GCCCCTCCCATCAGATGGAACCGGTTCGTGCCGTTT
GTTTTTAGCTTACCTATGAGGGATTGAAAC	ATCTTCCGGTTCTTAATTTTGCCGTATCCACACCCGA
GTTTTTAGCTTACCTATGAGGGATTGAAAC	TTCAACAGTAGTCTTTTTTCTGCCTCCACCAAACAAA
GTTTTTAGCTTACCTATGAGGGATTGAAAC	CGCTCTCGACAACCGACACCAGCGTGACGCCCGTCCTG
GTTTTTAGCTTACCTATGAGGGATTGAAAC	GGCTATCCAATTGTCCCTCGCCAGGCAGGAAACCAAAA
GTTTTTAGCTTACCTATGAGGGATTGAAAC	AAGCTACGTATAGAAATTACCTCGACTAAAATTATAGAT
GTTTTTAGCTTACCTATGAGGGATTGAAAC	TCTACTCCATCGCCAACAACATGGATCTGCCCGGTGA
GTTTTTAGCTTACCTATGAGGGATTGAAAC	ACCAATCGAACAATGACAAAAGGGAAATCCGGATCGG
GTTTTTAGCTTACCTATGAGGGATTGAAAC	AGGAAAAAGCAATTGAAATTTGCGACTTTATTAGGGAG
GTTTTTAGCTTACCTATGAGGGATTGAAAC	TTATACAGTTTGTCATTACGACCGCACGCATAGGCGGC
GTTTTTAGCTTACCTATGAGGGATTGAAAC	AAAAGGCCGACACTCTGGCACATAGCCAGAAATGTC
GTTTTTAGCTTACCTATGAGGGATTGAAAC	TAGGAAAAGTCTTATTAGAAAAGGAGGCATAATATGG
GTTTTTAGCTTACCTATGAGGGATTGAAAC	CCTAATAGATTATTTAGTATGTTTTTTATCTCTCCT
GTTTTTAGCTTACCTATGAGGGATTGAAAC	GAGGTTTTCCGCCTTCGTTAAGGAGCTCCTGGAAGA
GTTTTTAGCTTACCTATGAGGGATTGAAAC	TCGCCAAGGCCCATCTCCTCGAACGTGGGCTTCCAC
GTTTTTAGCTTACCTATGAGGGATTGAAAC	TGGCCCTGTCCCACACCTGTTCTTTTCGTGCGATCCAT
GTTTTTAGCTTACCTATCCTGAAAATAATG

>NC_014377|3|2|526446-529224|CRT
GTTTTTAGCTTACCTATGAGGGATTGAAAC	GGGGATCTTCCATGGCGTAAAATAAAAAATACTGAAGA
GTTTTTAGCTTACCTATGAGGGATTGAAAC	CCCGTCCGTAGCAACCGGAATATACTTCAGTCGAAT
GTTTTTAGCTTACCTATGAGGGATTGAAAC	CAGGTATATCGAGCCCTGCAAAAGCGGCAGTGATCA
GTTTTTAGCTTACCTATGAGGGATTGAAAC	AAACTGGAAAGCTCGTCTATTATCACCATATCAAAA
GTTTTTAGCTTACCTATGAGGGATTGAAAC	CGGCATCCGGATCAATCTCATCGAAGGTTACCGATACTGG
GTTTTTAGCTTACCTATGAGGGATTGAAAC	ATTGGATGCTGCGTATCCGCAGTCCACTCCGCTAC
GTTTTTAGCTTACCTATGAGGGATTGAAAC	ATTCCGTGTTAGTAAGGTGTTTCTCGTATATCTCGTC
GTTTTTAGCTTACCTATGAGGGATTGAAAC	CCAGCTTGGACGGCTCCTGGGTGCTGGACGGCACC
GTTTTTAGCTTACCTATGAGGGATTGAAAC	ATTTAGTTACGGTGCGGACAAAGACACATTTTTTAT
GTTTTTAGCTTACCTATGAGGGATTGAAAC	ATTAGTTCTCCGTCTACCGTTTCGAGGTCCCGAACTTC
GTTTTTAGCTTACCTATGAGGGATTGAAAC	CCGAAAGAAAAAGATTGAGTGTAAATTAAATGAACTT
GTTTTTAGCTTACCTATGAGGGATTGAAAC	AATATATTCCATATTAGACGCAAAAACCACCTTTCA
GTTTTTAGCTTACCTATGAGGGATTGAAAC	TCTACCTGTTTAATCATTGATATAACGGGAGCTACTCC
GTTTTTAGCTTACCTATGAGGGATTGAAAC	TGCCACAATTGCCGGCTCAGTTTATCCTCTCTCTC
GTTTTTAGCTTACCTATGAGGGATTGAAAC	GGGTATCGTACACAGTTTTACTGTTCCGCCGTATATAG
GTTTTTAGCTTACCTATGAGGGATTGAAAC	CATAGTCCGGGCCATAGCAGAGACCACAAACTACGA
GTTTTTAGCTTACCTATGAGGGATTGAAAC	TGCTTAAGGATAGGCTTAAAGAACTACGCAATAAAAAA
GTTTTTAGCTTACCTATGAGGGATTGAAAC	TAGACAATTTATACGCGTCCTATGTTATAGCCTTCTGT
GTTTTTAGCTTACCTATGAGGGATTGAAAC	ATACGCCACATCACGCAAGAATAAAAATCGAAAATAA
GTTTTTAGCTTACCTATGAGGATTGAAACA	TATACTTCAGGCTATGGGGACAATGCCAACGACGTG
GTTTTTAGCTTACCTATGAGGGATTGAAAC	TAGGCTTGTCCCTCCTACATAGATTCTTGTCTTTATT
GTTTTTAGCTTACCTATGAGGGATTGAAAC	TCAGGCAAGAATATTCACCGCTAACCAAAGGATACTTCAT
GTTTTTAGCTTACCTATGAGGGATTGAAAC	GACCATCTATAACACTAAAACCTTGCTGGCTGCTAT
GTTTTTAGCTTACCTATGAGGGATTGAAAC	GCGCCAAGAATCTCCGAAGTAGTGCGCCGTATTGGTCCT
GTTTTTAGCTTACCTATGAGGGATTGAAAC	TTGGATGAGCCTATGACTGTGGCTCATGCCAGGCTGA
GTTTTTAGCTTACCTATGAGGGATTGAAAC	GCCCCTCCCATCAGATGGAACCGGTTCGTGCCGTTT
GTTTTTAGCTTACCTATGAGGGATTGAAAC	ATCTTCCGGTTCTTAATTTTGCCGTATCCACACCCGA
GTTTTTAGCTTACCTATGAGGGATTGAAAC	TTCAACAGTAGTCTTTTTTCTGCCTCCACCAAACAAA
GTTTTTAGCTTACCTATGAGGGATTGAAAC	CGCTCTCGACAACCGACACCAGCGTGACGCCCGTCCTG
GTTTTTAGCTTACCTATGAGGGATTGAAAC	GGCTATCCAATTGTCCCTCGCCAGGCAGGAAACCAAAA
GTTTTTAGCTTACCTATGAGGGATTGAAAC	AAGCTACGTATAGAAATTACCTCGACTAAAATTATAGAT
GTTTTTAGCTTACCTATGAGGGATTGAAAC	TCTACTCCATCGCCAACAACATGGATCTGCCCGGTGA
GTTTTTAGCTTACCTATGAGGGATTGAAAC	ACCAATCGAACAATGACAAAAGGGAAATCCGGATCGG
GTTTTTAGCTTACCTATGAGGGATTGAAAC	AGGAAAAAGCAATTGAAATTTGCGACTTTATTAGGGAG
GTTTTTAGCTTACCTATGAGGGATTGAAAC	TTATACAGTTTGTCATTACGACCGCACGCATAGGCGGC
GTTTTTAGCTTACCTATGAGGGATTGAAAC	AAAAGGCCGACACTCTGGCACATAGCCAGAAATGTC
GTTTTTAGCTTACCTATGAGGGATTGAAAC	TAGGAAAAGTCTTATTAGAAAAGGAGGCATAATATGG
GTTTTTAGCTTACCTATGAGGGATTGAAAC	CCTAATAGATTATTTAGTATGTTTTTTATCTCTCCT
GTTTTTAGCTTACCTATGAGGGATTGAAAC	GAGGTTTTCCGCCTTCGTTAAGGAGCTCCTGGAAGA
GTTTTTAGCTTACCTATGAGGGATTGAAAC	TCGCCAAGGCCCATCTCCTCGAACGTGGGCTTCCAC
GTTTTTAGCTTACCTATGAGGGATTGAAAC	TGGCCCTGTCCCACACCTGTTCTTTTCGTGCGATCCAT
GTTTTTAGCTTACCTATCCTGAAAATAATG

Protein	Signature genes	Signature genes Name	Protein_function
NC_014377.1\|WP_013275345.1\|531987_532257_-\|AbrB/MazE/SpoVT-family-DNA-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|225215
NC_014377.1\|WP_013275334.1\|516729_517992_+\|WcaI-family-glycosyltransferase	unknown	unknown	gnl\|CDD\|236670
NC_014377.1\|WP_083768457.1\|530507_531602_+\|P1-family-peptidase	unknown	unknown	gnl\|CDD\|239071
NC_014377.1\|WP_013275352.1\|538004_539126_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm5	csm5gr7	cd09662_csm5gr7_CAS-III-A	gnl\|CDD\|187793
NC_014377.1\|WP_013275344.1\|531658_531988_-\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	unknown	unknown	gnl\|CDD\|182138
NC_014377.1\|WP_041423836.1\|536192_537026_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm3	csm3gr7	cd09684_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|187815
NC_014377.1\|WP_013275346.1\|532469_532862_+\|HEPN-domain-containing-protein	unknown	unknown	gnl\|CDD\|368314
NC_014377.1\|WP_013275341.1\|524584_525976_-\|MATE-family-efflux-transporter	unknown	unknown	gnl\|CDD\|240543
NC_014377.1\|WP_013275332.1\|513990_515415_+\|oligosaccharide-repeat-unit-polymerase	unknown	unknown	unknown
NC_014377.1\|WP_013275351.1\|537032_537992_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm4	csm4gr5	cd09663_csm4gr5_CAS-III-A	gnl\|CDD\|187794
NC_014377.1\|WP_013275340.1\|523043_524207_+\|glycerol-dehydrogenase	unknown	unknown	gnl\|CDD\|181843
NC_014377.1\|WP_013275347.1\|532815_533178_+\|nucleotidyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|143393
NC_014377.1\|WP_013275348.1\|533389_535756_+\|type-III-A-CRISPR-associated-protein-Cas10/Csm1	cas10	cd09680_cas10_CAS-III	gnl\|CDD\|187811
NC_014377.1\|WP_013275339.1\|521629_522586_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381326
NC_014377.1\|WP_013275333.1\|515440_516619_+\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340831
NC_014377.1\|WP_083768521.1\|524340_524532_-\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|372570
NC_014377.1\|WP_013275349.1\|535769_536192_+\|type-III-A-CRISPR-associated-protein-Csm2	csm2gr11	pfam03750_csm2gr11_CAS-III-A	gnl\|CDD\|367635
NC_014377.1\|WP_013275337.1\|520072_521410_+\|dNTP-triphosphohydrolase	unknown	unknown	gnl\|CDD\|234934
NC_014377.1\|WP_013275336.1\|519033_519963_+\|GDP-L-fucose-synthase	unknown	unknown	gnl\|CDD\|187550
NC_014377.1\|WP_013275335.1\|517988_519041_+\|GDP-mannose-4,6-dehydratase	unknown	unknown	gnl\|CDD\|178259

Protein	Function_ID	Function_description	E-value
NC_014377.1\|WP_013275345.1\|531987_532257_-\|AbrB/MazE/SpoVT-family-DNA-binding-domain-containing-protein	gnl\|CDD\|225215	COG2336, MazE, Growth regulator [Signal transduction mechanisms].	9.37346e-20
NC_014377.1\|WP_013275334.1\|516729_517992_+\|WcaI-family-glycosyltransferase	gnl\|CDD\|236670	PRK10307, PRK10307, colanic acid biosynthesis glycosyltransferase WcaI.	6.86789e-148
NC_014377.1\|WP_083768457.1\|530507_531602_+\|P1-family-peptidase	gnl\|CDD\|239071	cd02253, DmpA, L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active heterodimeric form. The cleavage results in two polypeptide chains, with one chain containing an N-terminal nucleophile. This group represents one of the rare aminopeptidases that are not metalloenzymes. DmpA shows similarity in catalytic mechanism to N-terminal nucleophile (Ntn) hydrolases, which are enzymes that catalyze the cleavage of amide bonds through the nucleophilic attack of the side chain of an N-terminal serine, threonine, or cysteine.	0
NC_014377.1\|WP_013275352.1\|538004_539126_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm5	gnl\|CDD\|187793	cd09662, Csm5_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein.	1.05984e-27
NC_014377.1\|WP_013275344.1\|531658_531988_-\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	gnl\|CDD\|182138	PRK09907, PRK09907, endoribonuclease MazF.	3.7153e-39
NC_014377.1\|WP_041423836.1\|536192_537026_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm3	gnl\|CDD\|187815	cd09684, Csm3_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein.	2.91366e-76
NC_014377.1\|WP_013275346.1\|532469_532862_+\|HEPN-domain-containing-protein	gnl\|CDD\|368314	pfam05168, HEPN, HEPN domain.	1.13958e-33
NC_014377.1\|WP_013275341.1\|524584_525976_-\|MATE-family-efflux-transporter	gnl\|CDD\|240543	cd13138, MATE_yoeA_like, Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.	2.42632e-122
NC_014377.1\|WP_013275351.1\|537032_537992_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm4	gnl\|CDD\|187794	cd09663, Csm4_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm4. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein.	1.32094e-60
NC_014377.1\|WP_013275340.1\|523043_524207_+\|glycerol-dehydrogenase	gnl\|CDD\|181843	PRK09423, gldA, glycerol dehydrogenase; Provisional.	0
NC_014377.1\|WP_013275347.1\|532815_533178_+\|nucleotidyltransferase-domain-containing-protein	gnl\|CDD\|143393	cd05403, NT_KNTase_like, Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins. S. aureus KNTase is a plasmid encoded enzyme which confers resistance to a wide range of aminoglycoside antibiotics which have a 4'- or 4''-hydroxyl group in the equatorial position, such as kanamycin A. This enzyme transfers a nucleoside monophosphate group from a nucleotide (ATP,GTP, or UTP) to the 4'-hydroxyl group of kanamycin A. This enzyme is a homodimer, having two NT active sites. The nucleotide and antibiotic binding sites of each active site include residues from each monomer. Included in this subgroup is Escherichia coli AadA5 which confers resistance to the antibiotic spectinomycin and is a putative aminoglycoside-3'-adenylyltransferase. It is part of the aadA5 cassette of a class 1 integron. This subgroup also includes Haemophilus influenzae HI0073 which forms a 2:2 heterotetramer with an unrelated protein HI0074. Structurally HI0074 is related to the substrate-binding domain of S. aureus KNTase. The genes encoding HI0073 and HI0074 form an operon. Little is known about the substrate specificity or function of two-component NTs. The characterized members of this subgroup may not be representive of the function of this subgroup. This subgroup belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, co-ordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are conserved in this subgroup.	8.05559e-15
NC_014377.1\|WP_013275348.1\|533389_535756_+\|type-III-A-CRISPR-associated-protein-Cas10/Csm1	gnl\|CDD\|187811	cd09680, Cas10_III, CRISPR/Cas system-associated protein Cas10. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Multidomain protein with permuted HD nuclease domain, palm domain and Zn-ribbon; signature gene for type III; also known as Csm1 family.	8.40269e-119
NC_014377.1\|WP_013275339.1\|521629_522586_-\|aldo/keto-reductase	gnl\|CDD\|381326	cd19100, AKR_unchar, uncharacterized aldo-keto reductase (AKR) superfamily protein. This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.	3.1075e-63
NC_014377.1\|WP_013275333.1\|515440_516619_+\|glycosyltransferase-family-4-protein	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	2.18943e-53
NC_014377.1\|WP_083768521.1\|524340_524532_-\|IS3-family-transposase	gnl\|CDD\|372570	pfam13333, rve_2, Integrase core domain.	0.00215868
NC_014377.1\|WP_013275349.1\|535769_536192_+\|type-III-A-CRISPR-associated-protein-Csm2	gnl\|CDD\|367635	pfam03750, Csm2_III-A, Csm2 Type III-A. Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-associated) proteins. This entry represents Csm2 Type III-A, a family of Cas proteins also known as TM1810/Csm2.	3.0031e-31
NC_014377.1\|WP_013275337.1\|520072_521410_+\|dNTP-triphosphohydrolase	gnl\|CDD\|234934	PRK01286, PRK01286, deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional.	9.01046e-121
NC_014377.1\|WP_013275336.1\|519033_519963_+\|GDP-L-fucose-synthase	gnl\|CDD\|187550	cd05239, GDP_FS_SDR_e, GDP-fucose synthetase, extended (e) SDRs. GDP-fucose synthetase (aka 3, 5-epimerase-4-reductase) acts in the NADP-dependent synthesis of GDP-fucose from GDP-mannose. Two activities have been proposed for the same active site: epimerization and reduction. Proteins in this subgroup are extended SDRs, which have a characteristic active site tetrad and an NADP-binding motif, [AT]GXXGXXG, that is a close match to the archetypical form. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	0
NC_014377.1\|WP_013275335.1\|517988_519041_+\|GDP-mannose-4,6-dehydratase	gnl\|CDD\|178259	PLN02653, PLN02653, GDP-mannose 4,6-dehydratase.	0

>NC_014377.1|WP_013275341.1|524584_525976_-|MATE-family-efflux-transporter
MARLADLFSPKDMTVGTPWKRIVEFSIPMLIGNIAQQLYNTVDSIVIGRYVGDNALAAVGSAFPVLNFLLVLFVAVASGASIMVAQYFGAKDRERLSRSIGVCITLTAIVSTLIMVISPFAIRPMLVFINTPESILDWCEDYLLILLVGNWGFSYFNILSGILRGLGDSFSALVFLLISTALNVVLDIWFVAGLNMGVPGVALATVIAQTVSAVLCIIKLKKMDDLFDFNLNMMKPIKEYVLQLLRLGLPSGLTQVIFSLAMITVQSLTNTFGEMIIACNVIVMRVDGFAMMPNFTFGITMTTFAGQNVGAKKMKRVELGTRQGLAIAVGVSTVITIIILIFGRYLMNIFTDTAELVDLSMRMMRILAVGYIAMAVTQVLSGVMRGAGDTVTPMWLSLITTIFLRVPIAYGIAYLTRSAEYPNGRPESIFVSLLIAWVFGAIITVIFFKKGNWKEKALLKDVR
>NC_014377.1|WP_083768521.1|524340_524532_-|IS3-family-transposase
MFYLIRVTIFGICRLKRAKGDDYEEYIDYYNTKRYQKRLKCMTPMEYRNYPAGIQHKESTNHF
>NC_014377.1|WP_013275340.1|523043_524207_+|glycerol-dehydrogenase
MRIPVPGVILIKYLGGRFTVTRAIIGPGKYVQGNGVLKDIKEHTMKLGRSFFIIASENGIKRTKPVIEESFAGEKVELVFEPFNGECSENEIERLKGLAEKNNSQVIVGIGGGKVLDTAKAIAYFLKLPVVVVPTVASTDAPCSALSVIYTDEGVFSKYLILPRNPDVVMVDTGFIVKAPARLLAAGMGDALATYFEARACFRSNATTLAGGKSTKAAMALAELCYRTLLEDGLKAKLAVENNACTLAVENIVEANTYLSGIGFESGGLAAAHAIHNGFTVLEECHHMYHGEKVAFGTIVQLVLENSPMEELEEVVGFCLDVGLPVTLEDLGIKEVKEADIRKVAEASCAEGETIHNMPFKVTPEDVYNAILGADALGRTLKNQYIR
>NC_014377.1|WP_013275339.1|521629_522586_-|aldo/keto-reductase
MKKNVLGMTGIEVTELCFGALPMGPLQKNLDLDSCVEVTAYALKKGINFIDTAQMYKTYEPIREAIKLTGINPVISTKSTASTYSDMEKAIDEALRALDRNYIDIFFMHAARVGEDVFDVRKEALKCLLDYKSKGYIKAVGISTHNVKVVELASQRDDIDVVFPIINYKGVGILGGSVEDMKKAIEVSSSRGKGVLLMKVLGGGVLLNEYKKSMDFARNLKGYHSIAVGMVSKEEVDFNVNYFNGIYDEEKSPVLGKNQKNFIVVDSLCKGCKTCLSACPNYAMEFAEERNKAYINREKCLTCGYCTASCPEFAIRVI
>NC_014377.1|WP_013275337.1|520072_521410_+|dNTP-triphosphohydrolase
MSNYGDGVVLRGDELIEFLDNQLANYAVKHKYGKEARLYPEKYDPNDNRNPFQHDRDRIIHSRAFRRLKGKTQVFTVSRNDHIRTRLSHTLEVAQLSRSVARALRLNEDLAEAIALGHDLGHPPFGHAAEEELNDILRGRTKLWTCDIGGFKHNINSLKIVDYFERAYAEFPGLNLTHWTREGILKHTGLNDKKDGLQVHDPTIDMSKLRLEVGVPSFLEGQIVAVCDELAQVTHDLEDAGRAGIVRDFSEEASPWCEIEIFSKALERARQERFYDETNLRSRLIRHLINLLMEDLISATEERIKKCILECGEVDPVKQPFSTKIVDFSADVAKQVENLQKLLRETVYASYEVSRGDIKARLYIQSIFKAYYDHPSRMPDYVYRKYNDAKGASESEELKRSNLEKFKDKIKNDPIFVRTIVEHIAGMTDQYLLNEYRQLFTPEIW
>NC_014377.1|WP_013275336.1|519033_519963_+|GDP-L-fucose-synthase
MHKGAKVYVAGHKGLVGSAILRKLQAEGYSNIVTRTHQELDLTNQQEVYRFFETERPEYVFLAAAKVGGILANSTYPAVFIRENLLIQTNIIDAAYRYGVKKLLFLGSSCIYPKFAPQPIKEEHLLTGALEPTNEPYAIAKIVGIKMCQAYNKQYGTNFISVMPTNLYGPGDNFDLETSHVLPALIRKFHEAKVAGAPHVVVWGSGTPRREFLHVDDLADACLFLMNNYDSSEIINIGVGKDLTIAELANLIKEIVGYKGEIVFDTSKPDGTPRKLLDVSKLFNLGWRPRIRLEDGIRSTYEWYMQNYT
>NC_014377.1|WP_013275335.1|517988_519041_+|GDP-mannose-4,6-dehydratase
MKKALITGITGQDGSYLTEFLLNKGYEVHGIIRRASTFNTDRIDHIYRDPHDQEARLFLHYGDLTDGTGLRRILEKVQPDEVYNLAAQSHVKVSFEQPEYTADVVATGTLRLLEALRDYIKVSGREVRFYQAGSSEMFGASPPPQNEKTPFYPRSPYAVSKVAAYWYAVNYREAYGMFICNGILFNHESPRRGETFVTRKITRAATRIKLGLQDKLYLGNLDAKRDWGYAGDYVEAMWLMLQQNEPDDYVIATGESHSVREFLEEAFGLLGLDWRQYVEIDPRYFRPTEVEFLLGDSTKARQKLGWKPKVTFKDLVKMMVEHDLLLAHQEKTLKDAGYAVALRGVASANA
>NC_014377.1|WP_013275334.1|516729_517992_+|WcaI-family-glycosyltransferase
MGLRLLIYGINYTPEPTGTGKYTGEMAAWLAARGHQVDAIVGLPHYPSWEVDPAYQDKGFHTEIIEGVRVLRVPHFVPSPERIGAIERIRLESSFSLKALRYWLLFLLQNNSYDAVIAICPPMQVGVYPWLYRLFRGVPWIFHIQDLQVDVAVRLGLLNGKLSKVLYTVENFLLRRATRVSTITEAMRRRIIAKGVPEKNTWLFPNWSDITFIRPMPRNNAFRQELRVAEDQILFMYAGNMGEKQGLELVLQAAEHLRYYSQLRFVLVGAGVAKQRLEKMAEEMKLTNVTFLPVQPLERLPEMLAAADVHLVVQKSEAADLVMPSKLTNILAAGRPVVATADSGTALHDVLTSYQAGIVTPPGDLKAFIDALQLLAESAILREQMGRNARLYAERYLDKERILKDFEDKLITLVREVRKR
>NC_014377.1|WP_013275333.1|515440_516619_+|glycosyltransferase-family-4-protein
MNILLVHNHYRQPGGEDSVFFSEKMLLSDQGHNVFFYTANNAQLEKFSAAGMIRNTLWNQKSYWDLRYLISKHSVQVAHFHNTFPLISPSAYYAAKSENIPVVQTLHNYRLLCPNALFFRAGHVCEDCLGRFVPWPGVLRRCYRGSIAASGVVATMLTFHRVLGTWKRMVDVYVALTEFARQKFIKAGFPAEKIVVKPNFVYPDPGVGEGKAGFTLFVGRLSPEKGLDTLLVAWERLEGKLPLKIVGDGPLAGKVIEATQRLIGVEWLGRRSREEVLALMKEASFLIFPSISHEGFPMTIVEAFAVGLPVLASNIGNMSNLIDPGRTGFHFRAGDSEDLAAKVEWAWAHTRQLMEMRREARAEYEAKYTAEKNYEMLMNIYQLAISRAKGRG
>NC_014377.1|WP_013275332.1|513990_515415_+|oligosaccharide-repeat-unit-polymerase
MNKRVSNNQKYFCYTKIFWLIFVFNLLAIILPLSFIINISEFRINSNGILTLFIIWYSSARLAILSAKGLKRLLSMTFWVFVYIWLGISPLFQVSVGRMPWPITTSEYHVTYALIISITGLLFYDVGMFLAGHLIKTNNTNYTPKLILDERKILLFAPISIVTAAVIIVAFFGGFDIFLLARAVRNAYLNELYSKSQLLLLDNLLRAIIFVSLQSVFVIWIRRTNNYLTKKNILKFIFLIVLIVLNLYINNPISTARYRFGFVVISLLFIGLKWNEKTSFPLWTLMMITFLLIIFPYADLFRNRADVSLKSLEFLPIYEHLVGNGDYDAFQQLSNTVAYVSKKGITWGKQLLGVIFFAIPRNLWPNKPLGSGEFIALNSGYYYTNLSCPLWAEAYLNGGFIAVIIIFTVYGILTKNIEHQYLSQQNGASFLDIFVPFFAPYQIFFLRGDLMSTFAYLIPNILFMLLVTKINCKR
>NC_014377.1|WP_083768457.1|530507_531602_+|P1-family-peptidase
MRKRMREWGLSIGLLPPGPLNAITDVEGVTVGHVTLISGEGSLISGKGPVRTGVTAIVPHCGNIFKEKLIASCFVGNGFGKSAGLVQVKELGTLETPIILTNTLSVGTAVDALIEYMLSSNDDIGITTGTVNPVVLECNDGHLNDIRGRHVKKEHVFSAISGAKKTFETGSVGAGTGMICHGFKGGIGTSSRRIEIDATAYTVGALLLTNYGRMEDLIFNGKNVGRILKEEIRGRERVGEKDEGSCIVVIATDAPLDAHGLERVAKRGILGLARTGSFMGNGSGDIAVAFSTANRIYHYGRPVIEVNTISPHSEDINKIFQAAVEAVEEAVWDSMFTAERIVGRDYHEAPLLPVERFLELVRER
>NC_014377.1|WP_013275344.1|531658_531988_-|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin
MQAPDRGDLVYVNFNPQSGHEQAGRRPGIVLSPKPFNQLTGFAVFCPITRQKKGYPFEVELPVGLAVQGVILADQVKSLDWRARQLQIVGRASNEIVSECLDLIHTFLS
>NC_014377.1|WP_013275345.1|531987_532257_-|AbrB/MazE/SpoVT-family-DNA-binding-domain-containing-protein
MELNEPKGVPLMTAKVQKWGNSLAIRIPSVVAERLGIHQGSEMEMIIENQAIKLIPKKKKPTLEELLAKITPENRHAEIDFGTEGNELF
>NC_014377.1|WP_013275346.1|532469_532862_+|HEPN-domain-containing-protein
MPNRAFDRLKQALKDLNHAQVSRKNGDHDWACFAAHQAGEKAVKALHLYLGQEAWGHVIARLLKDLPEGICVKEELIEKAKVLDNFYIPARYPDSHPDGAPFEHYGSLQSGEAIKYASEIVEFVRSQMAG
>NC_014377.1|WP_013275347.1|532815_533178_+|nucleotidyltransferase-domain-containing-protein
MPVRSLNSSVLKWPDKETVVYSLLEWVKEITQNRNDIVKIGYFGSYARGDWGVGSDLDIIIIVKKSDIPFNNRSAEWDTKGIPIPVDLLVYTVEEYENMKAMNSGFSKSIEKEVVWIYPL
>NC_014377.1|WP_013275348.1|533389_535756_+|type-III-A-CRISPR-associated-protein-Cas10/Csm1
MAFLFNDFTAEERNLLLAALLHDIGKFWQRTQDEPMRRIVSENYRAFYEARNHSSPGHQDWSAYFCETFVKIREVTNAVINHHGPSERLHYFVSAGDCLSAGERLDIAEEKGGEIRQLVSILSCIELDGLRSKKAYYKKLVPLGEYCVPEEEPSPNPKQGYKELWDAFIKAFNSIQNFDDPVELTKLYSILEEYTFNIPSAYYYSMPDISLWAHLKTAAAIAFALYRELEGKPNQHVISKLDSIIRRPSAVEEDLFCLVKGDISGIQDFVYDTKMDGATKALRGKSFYLSYLMTVIPKYILKKERLPITNLLYSGGGHFYLIMHGRFLQKLDEYQKELDGLFLDAHHGELALLLKGVTLKPADFRVKDGKLPEKFEELGKLLQEEKNRKFYSILKEDQKMVFGPFKEKGEPCPHCGNPVKEDECPFCRSFERLGENLIKKKFLVEEWKEKSERQKGSIEKVEDIFKRLGVSVEFTDEALEKDYSFAVKREEWDFKKCCGYMKIPVGMKLDQKGNIITFDEISDSAKGIKVWGVLRGDVDNLGRIFREGLGQNRSFARIMTLSQEMAQFFGPSLERMLNRLGSCDKSHSYENCAVIYAGGDDFFLVGPWDAMPYVAEEIKKEFYRYTGHNPAITVSMAFDIAPDKKFPLYRVAQTAGENLENAKHFKDPVRKKEKNCFAFAGVPIGWEDFDKFKDVKEKLFKALDELKVSRSLLGIIYRVCREYEVSANEDGKMFRSWRLFYYVARLKERNKKAEDILDKLIYLLIEKGNKLYKYAFQSARWAEFETRK
>NC_014377.1|WP_013275349.1|535769_536192_+|type-III-A-CRISPR-associated-protein-Csm2
MAWESNRKGKSDSFNDVKEIEERLPSALDKNKDPNGDDFFYCAEKTGKLLATKRVSVSQIRKIFNKARRIKYEENGIFELRMLKAVIAYTAGRFPENMKEFKGIFTKAIEIAEKSEENLKRFKQFFEAVVAYHRSYGGRE
>NC_014377.1|WP_041423836.1|536192_537026_+|type-III-A-CRISPR-associated-RAMP-protein-Csm3
MEVDFVKDLKLAGKYIITSEIVALTGLHIGTSSNTLEIGGVDNSVVKDALGRPYIPGSSLKGKMRALLEYAEGLITMVYVVHNERNESSNTRIHMCKKEDCAVCNIFGRNHGKHKVVDGNDPRGYRPVDFTDAVTPTRLIVRDATLIKESITEQMKENMDFEWTEVKFENNLDRVTSAANPRQTERVPAGARFKSEMVLTVFQGEGTKYIEKLLEAMLLLEDDYLGGQGTRGYGRIAFEKVSIAFRSVGYYEGREEEQVIVENCPSLREALGKIKRG
>NC_014377.1|WP_013275351.1|537032_537992_+|type-III-A-CRISPR-associated-RAMP-protein-Csm4
MDSGVKRYRVKLKFKGPVHFGYKEKTYNLTETFAHSDTLFSGIVNCYSLLYGKAAADNLVEMFFDNPPFKISSAFLYANDEFFVPRPLNMDLTPITGDYKKAKKVKYVPLDFILARDGGGKANKDYRVEHGILARKDMDTPYVISERPRVKIDRGDFSTEIYYVSGCYFREGAGLWFFLDIYDDSEEEKVKAAIRLLGDEGIGGERTYGFGSFEAGIEEYNEKKGNGSGDWLLLSLYYPRMDEKVADIIKAFSLLERAGYSYSPFNQQARKKKVRMLAEGSVFKKDVQGMVVDVSPGEDVGHKILKYGLAYTVPIFNRK
>NC_014377.1|WP_013275352.1|538004_539126_+|type-III-A-CRISPR-associated-RAMP-protein-Csm5
MEKPFQYEVEIISPVNIGDGNRYREFEYIIEGDSIGFIDVIKLLKSNKDNTSFIDYFYRSIDSFRFSWQDALKYAPKIDISEFISYQVKPCGASRVKGDIVSFIKTTGYPYIPGSSLKGSFRTGLMRGVWPSIEEEYKAKLDDTLREKDKKLKEIDDYPEEETFGKPHYSPFKFVRFSDSSLLPLDALGIYEMKILNICHGKAKWFKKNENVEESENATAIYIEALKPGIRAEGFFEIKQRTKNEEIYRIIKNVWILKNAFNAIRNDTKRYIEGEKYFYKEYGLDQVANFYQRLEELNGKLGENEILLQIGFGTGYLSKTIGCFLSAEDLKKLSKQGVRISDANLFPKTRRIIFANGNPDTVPGWVKITFREV

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Crispr_ID: NC_014377_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014377_4

541723-543432

TypeIII

Consensus_repeat	Method
GTTTTTAGCCTACCTATAAGGGATTGAAAC	PILER-CR
GTTTTTAGCCTACCTATAAGGGATTGAAAC	CRISPRCasFinder
GTTTTTAGCCTACCTATAAGGGATTGAAAC	CRT

25 spacers

csx3,csx1,cas6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10

The CRISPR arrays of NC_014377_4

>merge|NC_014377|4|541723-543432|PILER-CR,CRISPRCasFinder,CRT
GTTTTTAGCCTACCTATAAGGGATTGAAACAGATTTACTTGATATATATTCCCCTGCCTATCGCGGGTTTTTAGCCTACCTATAAGGGATTGAAACTCGGCGAAATGACGAGAAAGCCCGCAAAAAAGTAGTCCTTCGGTTTTTAGCCTACCTATAAGGGATTGAAACGAGACATTTCTCGTATTTGCGTAGGTCTGGTTTTTCGGGTTTTTAGCCTACCTATAAGGGATTGAAACCTGATTGATTATTTAGGAGCCGAAGACACGGAATATAGTTTTTAGCCTACCTATAAGGGATTGAAACGGGACTCAACAGAATAACTTTATCAAACCTGATTATAGTTTTTAGCCTACCTATAAGGGATTGAAACATCCACACGTTCGTAAAAATAATTCTGTATGCCATAGGTTTTTAGCCTACCTATAAGGGATTGAAACAATTCCGGCTGATCAGGTCTTTCTACATCTCCATCTCGTTTTTAGCCTACCTATAAGGGATTGAAACAAATTTATTTCCCCACTTTATCCGAAGAAACAAAAAGTTTTTAGCCTACCTATAAGGGATTGAAACTGCTGCCGCACATAGGACAATATCTTGCATTACTAGGTTTTTAGCCTACCTATAAGGGATTGAAACCACCGTAATCGATATAAATTCTCCACTTTATACCCAGGTTTTTAGCCTACCTATAAGGGATTGAAACTAGGTCTTATGGATAAGTTCGTTTTGTGTTGTGATAGTTTTTAGCCTACCTATAAGGGATTGAAACGTACTGTAGTCGACTGGGGCTGCCCTGTGGCCCTAGTGTTTTTAGCCTACCTATAAGGGATTGAAACTTTAGTTTTGACTTATAGGAATATGGAGAGATTAGAGTTTTTAGCCTACCTATAAGGGATTGAAACATTGATTTATTATTGGTATTTAAAGAAAATAGATGGTGTTTTTAGCCTACCTATAAGGGATTGAAACAAAAGCTCCCTTTCGGTAAGAAGATCCATGGAACCATGTTTTTAGCCTACCTATAAGGGATTGAAACTGGCATCCCGTTTACAAAAGTGAATAATCTTTTCGAGTTTTTAGCCTACCTATAAGGGATTGAAACACGAGGATCCCCTTCCAGGAATGGACATAAGCGAGGGTTTTTAGCCTACCTATAAGGGATTGAAACTTCAAACCCCACCGCCGTGCTGCTTCTGCTGCTGTGATCGTTTTTAGCCTACCTATAAGGGATTGAAACGCGGTTACAATTACAAGCGTAAGACGCATTGAGCAAGGTTTTTAGCCTACCTATAAGGGATTGAAACTCCAGGGATCGGGTGCAGATATGGTGAAGCTAGCTTCTGTTTTTAGCCTACCTATAAGGGATTGAAACCTGCAAACATCCTAGCTAAAAATGCAGGCGTAGACGGTTTTTAGCCTACCTATAAGGGATTGAAACTTGCCATTATTTTATATTTATCATTGCCATCAAAAACAGTTTTTAGCCTACCTATAAGGGATTGAAACGTGTTTGTGCTTTTATATGGTTACTAAAACATATAGGTATAGTTTTTAGCCTACCTATAAGGGATTGAAACCTAGATTGGTTAATGGGGGTTTCTGATGTTCGTAGCGTTTTTAGCCTACCTATAAGGGATTGAAACTCAGGAATAAGCTCAAGCGTCTTATTCCTGGTCCGGGGTTTTTAGCCTACCTATAAGGGATTGAAAC

>NC_014377|4|3|541723-543432|PILER-CR
GTTTTTAGCCTACCTATAAGGGATTGAAAC	AGATTTACTTGATATATATTCCCCTGCCTATCGCGG
GTTTTTAGCCTACCTATAAGGGATTGAAAC	TCGGCGAAATGACGAGAAAGCCCGCAAAAAAGTAGTCCTTCG
GTTTTTAGCCTACCTATAAGGGATTGAAAC	GAGACATTTCTCGTATTTGCGTAGGTCTGGTTTTTCGG
GTTTTTAGCCTACCTATAAGGGATTGAAAC	CTGATTGATTATTTAGGAGCCGAAGACACGGAATATA
GTTTTTAGCCTACCTATAAGGGATTGAAAC	GGGACTCAACAGAATAACTTTATCAAACCTGATTATA
GTTTTTAGCCTACCTATAAGGGATTGAAAC	ATCCACACGTTCGTAAAAATAATTCTGTATGCCATAG
GTTTTTAGCCTACCTATAAGGGATTGAAAC	AATTCCGGCTGATCAGGTCTTTCTACATCTCCATCTC
GTTTTTAGCCTACCTATAAGGGATTGAAAC	AAATTTATTTCCCCACTTTATCCGAAGAAACAAAAA
GTTTTTAGCCTACCTATAAGGGATTGAAAC	TGCTGCCGCACATAGGACAATATCTTGCATTACTAG
GTTTTTAGCCTACCTATAAGGGATTGAAAC	CACCGTAATCGATATAAATTCTCCACTTTATACCCAG
GTTTTTAGCCTACCTATAAGGGATTGAAAC	TAGGTCTTATGGATAAGTTCGTTTTGTGTTGTGATA
GTTTTTAGCCTACCTATAAGGGATTGAAAC	GTACTGTAGTCGACTGGGGCTGCCCTGTGGCCCTAGT
GTTTTTAGCCTACCTATAAGGGATTGAAAC	TTTAGTTTTGACTTATAGGAATATGGAGAGATTAGA
GTTTTTAGCCTACCTATAAGGGATTGAAAC	ATTGATTTATTATTGGTATTTAAAGAAAATAGATGGT
GTTTTTAGCCTACCTATAAGGGATTGAAAC	AAAAGCTCCCTTTCGGTAAGAAGATCCATGGAACCAT
GTTTTTAGCCTACCTATAAGGGATTGAAAC	TGGCATCCCGTTTACAAAAGTGAATAATCTTTTCGA
GTTTTTAGCCTACCTATAAGGGATTGAAAC	ACGAGGATCCCCTTCCAGGAATGGACATAAGCGAGG
GTTTTTAGCCTACCTATAAGGGATTGAAAC	TTCAAACCCCACCGCCGTGCTGCTTCTGCTGCTGTGATC
GTTTTTAGCCTACCTATAAGGGATTGAAAC	GCGGTTACAATTACAAGCGTAAGACGCATTGAGCAAG
GTTTTTAGCCTACCTATAAGGGATTGAAAC	TCCAGGGATCGGGTGCAGATATGGTGAAGCTAGCTTCT
GTTTTTAGCCTACCTATAAGGGATTGAAAC	CTGCAAACATCCTAGCTAAAAATGCAGGCGTAGACG
GTTTTTAGCCTACCTATAAGGGATTGAAAC	TTGCCATTATTTTATATTTATCATTGCCATCAAAAACA
GTTTTTAGCCTACCTATAAGGGATTGAAAC	GTGTTTGTGCTTTTATATGGTTACTAAAACATATAGGTATA
GTTTTTAGCCTACCTATAAGGGATTGAAAC	CTAGATTGGTTAATGGGGGTTTCTGATGTTCGTAGC
GTTTTTAGCCTACCTATAAGGGATTGAAAC	TCAGGAATAAGCTCAAGCGTCTTATTCCTGGTCCGGG
GTTTTTAGCCTACCTATAAGGGATTGAAAC

>NC_014377|4|4|541723-543432|CRISPRCasFinder
GTTTTTAGCCTACCTATAAGGGATTGAAAC	AGATTTACTTGATATATATTCCCCTGCCTATCGCGG
GTTTTTAGCCTACCTATAAGGGATTGAAAC	TCGGCGAAATGACGAGAAAGCCCGCAAAAAAGTAGTCCTTCG
GTTTTTAGCCTACCTATAAGGGATTGAAAC	GAGACATTTCTCGTATTTGCGTAGGTCTGGTTTTTCGG
GTTTTTAGCCTACCTATAAGGGATTGAAAC	CTGATTGATTATTTAGGAGCCGAAGACACGGAATATA
GTTTTTAGCCTACCTATAAGGGATTGAAAC	GGGACTCAACAGAATAACTTTATCAAACCTGATTATA
GTTTTTAGCCTACCTATAAGGGATTGAAAC	ATCCACACGTTCGTAAAAATAATTCTGTATGCCATAG
GTTTTTAGCCTACCTATAAGGGATTGAAAC	AATTCCGGCTGATCAGGTCTTTCTACATCTCCATCTC
GTTTTTAGCCTACCTATAAGGGATTGAAAC	AAATTTATTTCCCCACTTTATCCGAAGAAACAAAAA
GTTTTTAGCCTACCTATAAGGGATTGAAAC	TGCTGCCGCACATAGGACAATATCTTGCATTACTAG
GTTTTTAGCCTACCTATAAGGGATTGAAAC	CACCGTAATCGATATAAATTCTCCACTTTATACCCAG
GTTTTTAGCCTACCTATAAGGGATTGAAAC	TAGGTCTTATGGATAAGTTCGTTTTGTGTTGTGATA
GTTTTTAGCCTACCTATAAGGGATTGAAAC	GTACTGTAGTCGACTGGGGCTGCCCTGTGGCCCTAGT
GTTTTTAGCCTACCTATAAGGGATTGAAAC	TTTAGTTTTGACTTATAGGAATATGGAGAGATTAGA
GTTTTTAGCCTACCTATAAGGGATTGAAAC	ATTGATTTATTATTGGTATTTAAAGAAAATAGATGGT
GTTTTTAGCCTACCTATAAGGGATTGAAAC	AAAAGCTCCCTTTCGGTAAGAAGATCCATGGAACCAT
GTTTTTAGCCTACCTATAAGGGATTGAAAC	TGGCATCCCGTTTACAAAAGTGAATAATCTTTTCGA
GTTTTTAGCCTACCTATAAGGGATTGAAAC	ACGAGGATCCCCTTCCAGGAATGGACATAAGCGAGG
GTTTTTAGCCTACCTATAAGGGATTGAAAC	TTCAAACCCCACCGCCGTGCTGCTTCTGCTGCTGTGATC
GTTTTTAGCCTACCTATAAGGGATTGAAAC	GCGGTTACAATTACAAGCGTAAGACGCATTGAGCAAG
GTTTTTAGCCTACCTATAAGGGATTGAAAC	TCCAGGGATCGGGTGCAGATATGGTGAAGCTAGCTTCT
GTTTTTAGCCTACCTATAAGGGATTGAAAC	CTGCAAACATCCTAGCTAAAAATGCAGGCGTAGACG
GTTTTTAGCCTACCTATAAGGGATTGAAAC	TTGCCATTATTTTATATTTATCATTGCCATCAAAAACA
GTTTTTAGCCTACCTATAAGGGATTGAAAC	GTGTTTGTGCTTTTATATGGTTACTAAAACATATAGGTATA
GTTTTTAGCCTACCTATAAGGGATTGAAAC	CTAGATTGGTTAATGGGGGTTTCTGATGTTCGTAGC
GTTTTTAGCCTACCTATAAGGGATTGAAAC	TCAGGAATAAGCTCAAGCGTCTTATTCCTGGTCCGGG
GTTTTTAGCCTACCTATAAGGGATTGAAAC

>NC_014377|4|3|541723-543432|CRT
GTTTTTAGCCTACCTATAAGGGATTGAAAC	AGATTTACTTGATATATATTCCCCTGCCTATCGCGG
GTTTTTAGCCTACCTATAAGGGATTGAAAC	TCGGCGAAATGACGAGAAAGCCCGCAAAAAAGTAGTCCTTCG
GTTTTTAGCCTACCTATAAGGGATTGAAAC	GAGACATTTCTCGTATTTGCGTAGGTCTGGTTTTTCGG
GTTTTTAGCCTACCTATAAGGGATTGAAAC	CTGATTGATTATTTAGGAGCCGAAGACACGGAATATA
GTTTTTAGCCTACCTATAAGGGATTGAAAC	GGGACTCAACAGAATAACTTTATCAAACCTGATTATA
GTTTTTAGCCTACCTATAAGGGATTGAAAC	ATCCACACGTTCGTAAAAATAATTCTGTATGCCATAG
GTTTTTAGCCTACCTATAAGGGATTGAAAC	AATTCCGGCTGATCAGGTCTTTCTACATCTCCATCTC
GTTTTTAGCCTACCTATAAGGGATTGAAAC	AAATTTATTTCCCCACTTTATCCGAAGAAACAAAAA
GTTTTTAGCCTACCTATAAGGGATTGAAAC	TGCTGCCGCACATAGGACAATATCTTGCATTACTAG
GTTTTTAGCCTACCTATAAGGGATTGAAAC	CACCGTAATCGATATAAATTCTCCACTTTATACCCAG
GTTTTTAGCCTACCTATAAGGGATTGAAAC	TAGGTCTTATGGATAAGTTCGTTTTGTGTTGTGATA
GTTTTTAGCCTACCTATAAGGGATTGAAAC	GTACTGTAGTCGACTGGGGCTGCCCTGTGGCCCTAGT
GTTTTTAGCCTACCTATAAGGGATTGAAAC	TTTAGTTTTGACTTATAGGAATATGGAGAGATTAGA
GTTTTTAGCCTACCTATAAGGGATTGAAAC	ATTGATTTATTATTGGTATTTAAAGAAAATAGATGGT
GTTTTTAGCCTACCTATAAGGGATTGAAAC	AAAAGCTCCCTTTCGGTAAGAAGATCCATGGAACCAT
GTTTTTAGCCTACCTATAAGGGATTGAAAC	TGGCATCCCGTTTACAAAAGTGAATAATCTTTTCGA
GTTTTTAGCCTACCTATAAGGGATTGAAAC	ACGAGGATCCCCTTCCAGGAATGGACATAAGCGAGG
GTTTTTAGCCTACCTATAAGGGATTGAAAC	TTCAAACCCCACCGCCGTGCTGCTTCTGCTGCTGTGATC
GTTTTTAGCCTACCTATAAGGGATTGAAAC	GCGGTTACAATTACAAGCGTAAGACGCATTGAGCAAG
GTTTTTAGCCTACCTATAAGGGATTGAAAC	TCCAGGGATCGGGTGCAGATATGGTGAAGCTAGCTTCT
GTTTTTAGCCTACCTATAAGGGATTGAAAC	CTGCAAACATCCTAGCTAAAAATGCAGGCGTAGACG
GTTTTTAGCCTACCTATAAGGGATTGAAAC	TTGCCATTATTTTATATTTATCATTGCCATCAAAAACA
GTTTTTAGCCTACCTATAAGGGATTGAAAC	GTGTTTGTGCTTTTATATGGTTACTAAAACATATAGGTATA
GTTTTTAGCCTACCTATAAGGGATTGAAAC	CTAGATTGGTTAATGGGGGTTTCTGATGTTCGTAGC
GTTTTTAGCCTACCTATAAGGGATTGAAAC	TCAGGAATAAGCTCAAGCGTCTTATTCCTGGTCCGGG
GTTTTTAGCCTACCTATAAGGGATTGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_014377.1\|WP_013275351.1\|537032_537992_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm4	csm4gr5	cd09663_csm4gr5_CAS-III-A	gnl\|CDD\|187794
NC_014377.1\|WP_148218371.1\|543529_544794_+\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|366234
NC_014377.1\|WP_041423837.1\|553590_554622_-\|PTS-fructose-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|224218
NC_014377.1\|WP_041423838.1\|554643_554955_-\|PTS-fructose-transporter-subunit-IIB	unknown	unknown	gnl\|CDD\|224362
NC_014377.1\|WP_013275362.1\|550908_553539_-\|alpha-mannosidase	unknown	unknown	gnl\|CDD\|182093
NC_014377.1\|WP_013275353.1\|539131_539812_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	mkCas0062_cas6_CAS-I:CAS-III	gnl\|CDD\|273848
NC_014377.1\|WP_041423836.1\|536192_537026_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm3	csm3gr7	cd09684_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|187815
NC_014377.1\|WP_013275360.1\|548717_550418_+\|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|274171
NC_014377.1\|WP_013275346.1\|532469_532862_+\|HEPN-domain-containing-protein	unknown	unknown	gnl\|CDD\|368314
NC_014377.1\|WP_013275358.1\|546343_546856_+\|NADH-quinone-oxidoreductase-subunit-NuoE	unknown	unknown	gnl\|CDD\|376507
NC_014377.1\|WP_013275352.1\|538004_539126_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm5	csm5gr7	cd09662_csm5gr7_CAS-III-A	gnl\|CDD\|187793
NC_014377.1\|WP_013275354.1\|539812_541177_+\|TIGR01897-family-CRISPR-associated-protein	csx1	cd09728_csx1_CAS-III	gnl\|CDD\|273862
NC_014377.1\|WP_013275363.1\|555411_557379_-\|transcription-antiterminator	unknown	unknown	gnl\|CDD\|226234
NC_014377.1\|WP_013275348.1\|533389_535756_+\|type-III-A-CRISPR-associated-protein-Cas10/Csm1	cas10	cd09680_cas10_CAS-III	gnl\|CDD\|187811
NC_014377.1\|WP_041423839.1\|554951_555422_-\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|334031
NC_014377.1\|WP_013275359.1\|546839_548717_+\|NADH-quinone-oxidoreductase-subunit-NuoF	unknown	unknown	gnl\|CDD\|224806
NC_014377.1\|WP_013275349.1\|535769_536192_+\|type-III-A-CRISPR-associated-protein-Csm2	csm2gr11	pfam03750_csm2gr11_CAS-III-A	gnl\|CDD\|367635
NC_014377.1\|WP_013275361.1\|550490_550862_-\|Fe-S-cluster-assembly-scaffold-protein-NifU	unknown	unknown	gnl\|CDD\|132460
NC_014377.1\|WP_013275355.1\|541216_541501_+\|CRISPR-associated-protein-Csx3	csx3	cd09681_csx3_CAS-I:CAS-III	gnl\|CDD\|370583
NC_014377.1\|WP_013275347.1\|532815_533178_+\|nucleotidyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|143393

Protein	Function_ID	Function_description	E-value
NC_014377.1\|WP_013275351.1\|537032_537992_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm4	gnl\|CDD\|187794	cd09663, Csm4_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm4. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein.	1.32094e-60
NC_014377.1\|WP_148218371.1\|543529_544794_+\|IS3-family-transposase	gnl\|CDD\|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	3.81293e-23
NC_014377.1\|WP_041423837.1\|553590_554622_-\|PTS-fructose-transporter-subunit-IIC	gnl\|CDD\|224218	COG1299, FruA, Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism].	1.0302e-99
NC_014377.1\|WP_041423838.1\|554643_554955_-\|PTS-fructose-transporter-subunit-IIB	gnl\|CDD\|224362	COG1445, FrwB, Phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism].	4.81986e-38
NC_014377.1\|WP_013275362.1\|550908_553539_-\|alpha-mannosidase	gnl\|CDD\|182093	PRK09819, PRK09819, mannosylglycerate hydrolase.	0
NC_014377.1\|WP_013275353.1\|539131_539812_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	2.08704e-11
NC_014377.1\|WP_041423836.1\|536192_537026_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm3	gnl\|CDD\|187815	cd09684, Csm3_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein.	2.91366e-76
NC_014377.1\|WP_013275360.1\|548717_550418_+\|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein	gnl\|CDD\|274171	TIGR02512, Periplasmic_hydrogenase_large_subunit, [FeFe] hydrogenase, group A. This model describes iron-only hydrogenases of anaerobic and microaerophilic bacteria and protozoa. This model is narrower, and covers a longer stretch of sequence, than pfam02906. This family represents a division among families that belong to pfam02906, which also includes proteins such as nuclear prelamin A recognition factor in animals. Note that this family shows some heterogeneity in terms of periplasmic, cytosolic, or hydrogenosome location, NAD or NADP dependence, and overal protein protein length.	0
NC_014377.1\|WP_013275346.1\|532469_532862_+\|HEPN-domain-containing-protein	gnl\|CDD\|368314	pfam05168, HEPN, HEPN domain.	1.13958e-33
NC_014377.1\|WP_013275358.1\|546343_546856_+\|NADH-quinone-oxidoreductase-subunit-NuoE	gnl\|CDD\|376507	pfam01257, 2Fe-2S_thioredx, Thioredoxin-like [2Fe-2S] ferredoxin.	2.84888e-75
NC_014377.1\|WP_013275352.1\|538004_539126_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm5	gnl\|CDD\|187793	cd09662, Csm5_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein.	1.05984e-27
NC_014377.1\|WP_013275354.1\|539812_541177_+\|TIGR01897-family-CRISPR-associated-protein	gnl\|CDD\|273862	TIGR01897, hypothetical_protein, CRISPR-associated protein, MJ1666 family. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This model describes a Cas protein about 400 residues in length, found mostly in the Archaea but also in Aquifex.	2.50221e-36
NC_014377.1\|WP_013275363.1\|555411_557379_-\|transcription-antiterminator	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	1.15048e-62
NC_014377.1\|WP_013275348.1\|533389_535756_+\|type-III-A-CRISPR-associated-protein-Cas10/Csm1	gnl\|CDD\|187811	cd09680, Cas10_III, CRISPR/Cas system-associated protein Cas10. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Multidomain protein with permuted HD nuclease domain, palm domain and Zn-ribbon; signature gene for type III; also known as Csm1 family.	8.40269e-119
NC_014377.1\|WP_041423839.1\|554951_555422_-\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|334031	pfam00359, PTS_EIIA_2, Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2.	3.32097e-49
NC_014377.1\|WP_013275359.1\|546839_548717_+\|NADH-quinone-oxidoreductase-subunit-NuoF	gnl\|CDD\|224806	COG1894, NuoF, NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion].	0
NC_014377.1\|WP_013275349.1\|535769_536192_+\|type-III-A-CRISPR-associated-protein-Csm2	gnl\|CDD\|367635	pfam03750, Csm2_III-A, Csm2 Type III-A. Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-associated) proteins. This entry represents Csm2 Type III-A, a family of Cas proteins also known as TM1810/Csm2.	3.0031e-31
NC_014377.1\|WP_013275361.1\|550490_550862_-\|Fe-S-cluster-assembly-scaffold-protein-NifU	gnl\|CDD\|132460	TIGR03419, NifU_clost, FeS cluster assembly scaffold protein NifU, Clostridium type. NifU and NifS form a pair of iron-sulfur (FeS) cluster biosynthesis proteins much simpler than the ISC and SUF systems. Members of this protein family are a distinct group of NifU-like proteins, found always to a NifS-like protein and restricted to species that lack a SUF system. Typically, NIF systems service a smaller number of FeS-containing proteins than do ISC or SUF. Members of this particular branch typically are found, almost half the time, near the mnmA gene, involved in the carboxymethylaminomethyl modification of U34 in some tRNAs (see GenProp0704). While other NifU proteins are associated with nitrogen fixation, this family is not. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	2.14848e-65
NC_014377.1\|WP_013275355.1\|541216_541501_+\|CRISPR-associated-protein-Csx3	gnl\|CDD\|370583	pfam09620, Cas_csx3, CRISPR-associated protein (Cas_csx3). This entry is encoded in CRISPR-associated (cas) gene clusters, near CRISPR repeats, in the genomes of several different thermophiles: Archaeoglobus fulgidus (archaeal), Aquifex aeolicus (Aquificae), Dictyoglomus thermophilum (Dictyoglomi), and a thermophilic Synechococcus (Cyanobacteria). It is not yet assigned to a specific CRISPR/cas subtype (hence the x designation csx3).	6.84438e-41
NC_014377.1\|WP_013275347.1\|532815_533178_+\|nucleotidyltransferase-domain-containing-protein	gnl\|CDD\|143393	cd05403, NT_KNTase_like, Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins. S. aureus KNTase is a plasmid encoded enzyme which confers resistance to a wide range of aminoglycoside antibiotics which have a 4'- or 4''-hydroxyl group in the equatorial position, such as kanamycin A. This enzyme transfers a nucleoside monophosphate group from a nucleotide (ATP,GTP, or UTP) to the 4'-hydroxyl group of kanamycin A. This enzyme is a homodimer, having two NT active sites. The nucleotide and antibiotic binding sites of each active site include residues from each monomer. Included in this subgroup is Escherichia coli AadA5 which confers resistance to the antibiotic spectinomycin and is a putative aminoglycoside-3'-adenylyltransferase. It is part of the aadA5 cassette of a class 1 integron. This subgroup also includes Haemophilus influenzae HI0073 which forms a 2:2 heterotetramer with an unrelated protein HI0074. Structurally HI0074 is related to the substrate-binding domain of S. aureus KNTase. The genes encoding HI0073 and HI0074 form an operon. Little is known about the substrate specificity or function of two-component NTs. The characterized members of this subgroup may not be representive of the function of this subgroup. This subgroup belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, co-ordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are conserved in this subgroup.	8.05559e-15

>NC_014377.1|WP_013275355.1|541216_541501_+|CRISPR-associated-protein-Csx3
MVKFDTAEYGKYTILHFELEGPINPEILKDICPPKVNSTKGLIISGRGPIWLYCYLVHYYHFTVFIATFDPRLGGAVIVESHIPEFKPGNVIML
>NC_014377.1|WP_013275354.1|539812_541177_+|TIGR01897-family-CRISPR-associated-protein
MNSLIYQIGRLDRNIIKKQKFTIEGKTRSKQLSSFALKEHLKENGEQAKVILVYPVSLPFNRTLENANFGDFSRSLKAVLRNPKEEYLSNPKNFFSNMPYSSEVDDFIVIHSIGEYAGINFQGKFNDIVFEIALDMIERYNEEIERIYVDISSGLNIYVSALLEAVRFFSIWATLKNWLPEAKRPEIWITFSDPILDNEAAEYQLHREKLEFKAFFASPINKEDINNVAKKIYEDDRSKKRKLSSLLENFLVIFSAIKNNIPLAVYLFGYEDGEVIDETSRTLIEDMKKKLYDSYAASPNLDKNTYSKGLLSLAFYSGIAEVFWHYQIKNHDEDDGIDLDELKRIFDDLYSLFSLKPNNVFLGNEISNTKRIMGKINIEDSTWHLLIKFHNKEYEGRTPDKRNFFAHSGLEGLVTEMKKEKDKFFVRYTREYTDKSGNKKSVKNLIREWLKEEA
>NC_014377.1|WP_013275353.1|539131_539812_+|CRISPR-associated-endoribonuclease-Cas6
MFRLRLEIYFKKDAFFFDRGYKINLSSYFREVIKNQFFVFSDIIPSKKKPAKDGFWALDRAALILNTAFQELLPDIALKIMNTPVDFRYGRLTFSKAIFQRVPLERTGYLLSPVAVALPAGENLLWEERPERFSEALRQMLVDKYIRLYGRRPSDDRFLFRFRGRPVKEELDSGVIAYRGKFEIFSSEELVMLSYLCGLGSFNAMGYGMASPDLYLWKKPETMEGI
>NC_014377.1|WP_013275352.1|538004_539126_+|type-III-A-CRISPR-associated-RAMP-protein-Csm5
MEKPFQYEVEIISPVNIGDGNRYREFEYIIEGDSIGFIDVIKLLKSNKDNTSFIDYFYRSIDSFRFSWQDALKYAPKIDISEFISYQVKPCGASRVKGDIVSFIKTTGYPYIPGSSLKGSFRTGLMRGVWPSIEEEYKAKLDDTLREKDKKLKEIDDYPEEETFGKPHYSPFKFVRFSDSSLLPLDALGIYEMKILNICHGKAKWFKKNENVEESENATAIYIEALKPGIRAEGFFEIKQRTKNEEIYRIIKNVWILKNAFNAIRNDTKRYIEGEKYFYKEYGLDQVANFYQRLEELNGKLGENEILLQIGFGTGYLSKTIGCFLSAEDLKKLSKQGVRISDANLFPKTRRIIFANGNPDTVPGWVKITFREV
>NC_014377.1|WP_013275351.1|537032_537992_+|type-III-A-CRISPR-associated-RAMP-protein-Csm4
MDSGVKRYRVKLKFKGPVHFGYKEKTYNLTETFAHSDTLFSGIVNCYSLLYGKAAADNLVEMFFDNPPFKISSAFLYANDEFFVPRPLNMDLTPITGDYKKAKKVKYVPLDFILARDGGGKANKDYRVEHGILARKDMDTPYVISERPRVKIDRGDFSTEIYYVSGCYFREGAGLWFFLDIYDDSEEEKVKAAIRLLGDEGIGGERTYGFGSFEAGIEEYNEKKGNGSGDWLLLSLYYPRMDEKVADIIKAFSLLERAGYSYSPFNQQARKKKVRMLAEGSVFKKDVQGMVVDVSPGEDVGHKILKYGLAYTVPIFNRK
>NC_014377.1|WP_041423836.1|536192_537026_+|type-III-A-CRISPR-associated-RAMP-protein-Csm3
MEVDFVKDLKLAGKYIITSEIVALTGLHIGTSSNTLEIGGVDNSVVKDALGRPYIPGSSLKGKMRALLEYAEGLITMVYVVHNERNESSNTRIHMCKKEDCAVCNIFGRNHGKHKVVDGNDPRGYRPVDFTDAVTPTRLIVRDATLIKESITEQMKENMDFEWTEVKFENNLDRVTSAANPRQTERVPAGARFKSEMVLTVFQGEGTKYIEKLLEAMLLLEDDYLGGQGTRGYGRIAFEKVSIAFRSVGYYEGREEEQVIVENCPSLREALGKIKRG
>NC_014377.1|WP_013275349.1|535769_536192_+|type-III-A-CRISPR-associated-protein-Csm2
MAWESNRKGKSDSFNDVKEIEERLPSALDKNKDPNGDDFFYCAEKTGKLLATKRVSVSQIRKIFNKARRIKYEENGIFELRMLKAVIAYTAGRFPENMKEFKGIFTKAIEIAEKSEENLKRFKQFFEAVVAYHRSYGGRE
>NC_014377.1|WP_013275348.1|533389_535756_+|type-III-A-CRISPR-associated-protein-Cas10/Csm1
MAFLFNDFTAEERNLLLAALLHDIGKFWQRTQDEPMRRIVSENYRAFYEARNHSSPGHQDWSAYFCETFVKIREVTNAVINHHGPSERLHYFVSAGDCLSAGERLDIAEEKGGEIRQLVSILSCIELDGLRSKKAYYKKLVPLGEYCVPEEEPSPNPKQGYKELWDAFIKAFNSIQNFDDPVELTKLYSILEEYTFNIPSAYYYSMPDISLWAHLKTAAAIAFALYRELEGKPNQHVISKLDSIIRRPSAVEEDLFCLVKGDISGIQDFVYDTKMDGATKALRGKSFYLSYLMTVIPKYILKKERLPITNLLYSGGGHFYLIMHGRFLQKLDEYQKELDGLFLDAHHGELALLLKGVTLKPADFRVKDGKLPEKFEELGKLLQEEKNRKFYSILKEDQKMVFGPFKEKGEPCPHCGNPVKEDECPFCRSFERLGENLIKKKFLVEEWKEKSERQKGSIEKVEDIFKRLGVSVEFTDEALEKDYSFAVKREEWDFKKCCGYMKIPVGMKLDQKGNIITFDEISDSAKGIKVWGVLRGDVDNLGRIFREGLGQNRSFARIMTLSQEMAQFFGPSLERMLNRLGSCDKSHSYENCAVIYAGGDDFFLVGPWDAMPYVAEEIKKEFYRYTGHNPAITVSMAFDIAPDKKFPLYRVAQTAGENLENAKHFKDPVRKKEKNCFAFAGVPIGWEDFDKFKDVKEKLFKALDELKVSRSLLGIIYRVCREYEVSANEDGKMFRSWRLFYYVARLKERNKKAEDILDKLIYLLIEKGNKLYKYAFQSARWAEFETRK
>NC_014377.1|WP_013275347.1|532815_533178_+|nucleotidyltransferase-domain-containing-protein
MPVRSLNSSVLKWPDKETVVYSLLEWVKEITQNRNDIVKIGYFGSYARGDWGVGSDLDIIIIVKKSDIPFNNRSAEWDTKGIPIPVDLLVYTVEEYENMKAMNSGFSKSIEKEVVWIYPL
>NC_014377.1|WP_013275346.1|532469_532862_+|HEPN-domain-containing-protein
MPNRAFDRLKQALKDLNHAQVSRKNGDHDWACFAAHQAGEKAVKALHLYLGQEAWGHVIARLLKDLPEGICVKEELIEKAKVLDNFYIPARYPDSHPDGAPFEHYGSLQSGEAIKYASEIVEFVRSQMAG
>NC_014377.1|WP_148218371.1|543529_544794_+|IS3-family-transposase
MKKKRYDREFKEQVVRECQEVGNIALVARRHGLSKNTVYNWLQATRKNGSVIPLPRDVNQRLLEAENRLESLARENDQLKRLVAEKELELAILRELRDRVNPPVADKVAIAKRWVAKGYSLYLVLGFVGLAPSTFYAYESKKEPTVTADNQAKAKAGRPKTQFSYTLDGKKVADEQIKEWLCELVCQDGFPYGYKKLTAALVEDYGLVINHKKVYRLCKELDILKPQRICKSKHPRRLAQRIEVTGPNQLWEMDVKYGYIHGEERFFFQLSLIDVFDRCVIDYHLGLTCTAKDARRVLCNALKKRGIKPGMQMPRLRTDNGPQFIANLFAAACRKLGIVHERIPVKTPNLNAHIEAFHSILEDECYSRHQFASYAEAYEQIAWYMDYYNNRRRHGSLNNMAPQKYYQAIISNSIKPKSLVA
>NC_014377.1|WP_013275358.1|546343_546856_+|NADH-quinone-oxidoreductase-subunit-NuoE
MATATGHGRSFQRVDEIIEAHGRNPVNIISILQEVQNEYRYLPQDVLNYIATAMNISPSKVYGVATFYENFSLEPKGKYVIRICDGTACHVKNSTALLNALTKKLGLKEGQRTTEDLLFTLETVSCLGACGLAPVMVVNEEVHGKVTPEKAEEIIDEIINKERGQNDKER
>NC_014377.1|WP_013275359.1|546839_548717_+|NADH-quinone-oxidoreductase-subunit-NuoF
MIKSVEELNKLKDECSKALAGEKMKILVCAGTGCISGGSLKVYEAIKKLLEEKNLYVDIDLYTEDKEGVNVSPSGCHGFCQMGPIVRVEPQGYFYVKVKEEDAQEIVEKTVEKGEPVERLLYKSHEDGQAFMTEDSIPFYGKQSRIVLEHCGKINPENIKEYIAAGGYQALAKALQMTPEEICQVMLKAKLRGRGGAGFPAGIKWDSVRKQKSDVKYVICNGDEGDPGAFMDRSIMEGDPHRVIEGMIIAGYASGATQGYIYVRAEYPLAVRRLKKAIEQAREFGLLGKNILGSGFDFDIKINMGAGAFVCGEGSALIASIEGQRGMPKTRPPRTVEKGLFGKPTVLNNVETYANVPMIILNGADWYLSIGTETSPGTKAFALTGNIVNTGLIEVPMGTTLREVIYEIGGGIPNGKELKAVQIGGPSGGCLTKEHLDLPLDFDTLGTVGAMIGSGGMVVMDEDTCMVEVARFFMSFTQRESCGKCVPCREGTKRMLKLLEKITSGKGTEKDLELLEELAVTVKDGSLCGLGQTAPNPVLTTLKYFRDEYLAHVREKRCPAGVCQALKRYAIDATVCKGCSKCSRVCPVGAISGEIKKPFTINPDKCIKCGACVEACPFKAVKEGK
>NC_014377.1|WP_013275360.1|548717_550418_+|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein
MKTLKINGREVAFSDEKNLLEVIRKAGIELPTFCYHSELSTYGACRMCLVEDKRGNLIAACSTPPREGMEIKTHTKRLLKQRRMTLELILAEHDRDCTTCGKNGDCKLRKLSHDLGVEEIRFGTKENYLPIDDSSEAIVRNPNKCILCGDCVRMCEEVQGIGVIGFAHRGAKAVVTPAFNKNLCEVECVDCGQCSAVCPTGAIVVKSHIDKVWDALNDDNKVVIAQIAPAVRVAFGEAFGLRPGESTEYLIVSALKAMGFDMVFDTCFAADLTVIEEGHEFLERLEKGENLPLFTSCCPAWVKFVEFNYPSFLNNLSSCRSPHQMFGSFTKNYYAKELGVSRENVYVVSIMPCTAKKAEAAREELGVDGNPDVDAVLTTRELIRMVREAGIVFKDLKEEPFDMPFGFSTGGGIIFGATGGVAEAVVRTLDGGHRRFEQVRGSEGLKEATIVKDGKEIRVAVVHGLKNARELLEKIKSGSVKYDMVEVMACPGGCVGGAGQPSPASTGVREERAKGLYNIDNRMQLARSDENPMIKMLYEKWLGSPGSEVAHKYLHTHYRPRRRTEV
>NC_014377.1|WP_013275361.1|550490_550862_-|Fe-S-cluster-assembly-scaffold-protein-NifU
MYNEKVLDHFSNPRNAGEIPDADGIGHAGNPVDGDSITIYIKVKDGIIDDIKFKTFGCGAAIAASSMLTVLAKGKTLDEALKITNDQVAEALGGLPPQKLNCSNIAADALHDAIADYKNKISR
>NC_014377.1|WP_013275362.1|550908_553539_-|alpha-mannosidase
MNLYVVCHTHWDREWHKTFHEYRVKLVEFMDDLIDLLERDENYTSFLLDGQTVVLEDYLDVKPYMKERIRRLVKAGRLVIGPWYVQPDEFLVSGESLIRNLLIGHEIGKDFGRVMKVGYLPDSFGQAACIPQLLKGFGIDSAVFWRGVTDEDLDKTEFLWESPDGSRVFAVHLPLGYGNGASLSKNMAMSFETVEENLKKLASKAATNNILLMCGFDQRFADHDIPEIIKELNSYYKENGKDIRLIQCSIEDYIEKVKSEEPSLKVLKGEFRKGKSMRVHVSIGGTRLDIKRDNFNTQLLYERYLEPISTMAYILGHKYDNDIINRGWKYIIQNHAHDSICTVCTDDTHREMKIRFEFAKQIGHTLLNEKISEISGDIAYKKEMGKPLIVFNTLMRKRKEPVEATIYLDTEEFSLTDNEGRKIPYQIMSVKDVNLAEKEIEIGVKNPDRWVKEIKLVFIAELDGFGYRTYYVKEHAKSNRYTGFIGAGNILENEFYRVSVEDDGSLCITDKETAKTYRGLNIFEESGNAGDEYDFSPPKEDVVITTRGSRPEIALVENGPLFARIRISHILNVPMDTDSMKRAEKTCPCPVDCFVTLYRGIKRVDIKTVIDNRAKNHRIRVLFDGNVEAHTHIAEQQFGVLKRDNFLKEQECWDKEGWEERYYPVYPQRSFVDVSDGQYGLAILNKGLPQYEILNKDKPIIALTLLSGTDYMGKNDLRYRPGRRSGLHIAVPDSQLLGVHEVEYSIVPHKGDYIAGDIIESAHSYITPLLSFMPLNETQGELNDELYFIKTENKGIIESSIKKSEHGPAVVLRIYNGTDLPLRNIVLKLDDRFNAVDILDLKEEKIKNNNKVSFVENKINIPLLNENEIISLSLGR
>NC_014377.1|WP_041423837.1|553590_554622_-|PTS-fructose-transporter-subunit-IIC
MNNKIWENARRHLMTGVSYMIPFVVSGGLLLTIGILIGGGKVIPGMSKTLVDLGVTAFQMMVPIMAGYMAYSMADRPGIAPGIVGGLIANKIGAGFLGGIVAGFIAGWVVNQLKRIPLHPYIAPLKPIIIIPFFGVGIVAGLMLIIGQPISALSKTLEAWLNSMTGANAALLGFIIAAMMAFDMGGPVNKIAFAFSAGMLSQGVYAPMAACWVGIMAPPMGLALATYLAPKKFTEVERKNAIPAAIMGATGITEGAIPYAAADPLRVIPSLVIGSGFGGAVALLLGAQAPVPSGGVFVIPFFIKPLMFVIGFAAAIIVTALITVALKKEVTEEENNFEGLNLE
>NC_014377.1|WP_041423838.1|554643_554955_-|PTS-fructose-transporter-subunit-IIB
MKIVAVTACPSGVAHTYMAATALKKAAKANGAQIKIETQGALGIENEITEKEAREADAVILAIETAIAKPERFKNKPVIQVPVSEAIKDADAIIKKAMSLISK
>NC_014377.1|WP_041423839.1|554951_555422_-|PTS-sugar-transporter-subunit-IIA
MIIKDILKRELIELNMGAKTKEEVINEMADMLFKSGAITSKEAFVKDVFERERIGTTGVGMGIAIPHGRSGSVINTSVAIAKLKEPVDWDSLDGKPVSLVFLLAVPKDGGENIHLKLLSGIASMLMEEDFREKLFKASDKEEVLNIMGFVKEDDLK
>NC_014377.1|WP_013275363.1|555411_557379_-|transcription-antiterminator
MDLDARKKKIIEELLISKGPVTGEYLAGVLGVSSRTIRSDIKIINEQLKESGIKIISSPGVGYSLEYDDEEKLSGILREIMKESQGYIVPTLPEDRVRYIRGKLLAADGFITLESLADELYVSKSTVEKDMEKVEEWFSSHNIKIFKKPNYGMKLQGSEMDLRFAMSDHLRSLKDEKVFAVDLPDIGDIVKDVDIEVIKDVIDEVLERIPFKLSDVAYTNLIIHIAIAVKRIRESKSIELPPGEITNLKDKMEYSVAADMVKSLESKFNISIPEAEIGYITMHLMGTKVLEDGSLSKEKIKKAVGEEIYRVATRMIEEVKRVYGIDFTADDELIYGLALHLKPTITRIKYGMNLKNPLLKEIKEEYPQAFELAVVASRVLEDVYKIKVDENEMGYIAVYFGAAIERGNYRESNQIKRVAVVCASGMGTAQLLATRIRKTFPNITITGVYPAFKSSEIIKQRPDFILSTVPLENMDIPVIEISPLLNKNDLRRLKAVILSEDEDVDRSILLKFMKEDLFFKGISASDCFEVIDKMSDSLYQKGYVTKGFKESAKQREKISSTGIGNLVAIPHAMLGHAIGSHIAVGILEKPIKWGSSQAQLIFMIALEKLSDREFQHIFEALYDVVDDPSLVAKLIKARDFNEFARILKGRGRYDN

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Crispr_ID: NC_014377_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014377_5

544799-545300

TypeIII

Consensus_repeat	Method
NGTTTTTAGCCTACCTATAAGGGATTGAAAC	CRT
GTTTTTAGCCTACCTATAAGGGATTGAAAC	PILER-CR
GTTTTTAGCCTACCTATAAGGGATTGAAAC	CRISPRCasFinder

6 spacers

csx3,csx1,cas6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10

The CRISPR arrays of NC_014377_5

>merge|NC_014377|5|544799-545300|CRT,PILER-CR,CRISPRCasFinder
CAAAATTAGGGGGTCAAGGCGGATTGAAACACTGAAAAAGGGGCGGTGTTTTTGCCTATTCTATATAAAGTTTTTAGCCTACCTATAAGGGATTGAAACAGATCGTAGCGGCGACAATAGCAAGAAACTGGTCGAGTTTTTAGCCTACCTATAAGGGATTGAAACATGGATAAGATTTATAGACTTCAGAATGGGGAAATTACGTTTTTAGCCTACCTATAAGGGATTGAAACAGTCAATGGCTTTGGCTCTAGCAGAGCCTTTCTCTTCACGTTTTTAGCCTACCTATAAGGGATTGAAACCGATATGGCGGTATCTCAAGTGGCAGAGGTTGCAATAGTTTTTAGCCCACCTATAAGGGATTGAAACATTGAATCCATATTCTTTTTTCGAGGGACAAAATCGAAGTTTTTAGCCTACCTATAAGGGATTGAAACTATTCTCTTGCAGGGATATCGATTTGTGCCACATAGTTTTTAGCCTACCTATCCTGAAAATAATG

>NC_014377|5|4|544799-545235|CRT
CAAAATTAGGGGGTCAAGGCGGATTGAAAC	ACTGAAAAAGGGGCGGTGTTTTTGCCTATTCTATATAAA
GTTTTTAGCCTACCTATAAGGGATTGAAAC	AGATCGTAGCGGCGACAATAGCAAGAAACTGGTCGA
GTTTTTAGCCTACCTATAAGGGATTGAAAC	ATGGATAAGATTTATAGACTTCAGAATGGGGAAATTAC
GTTTTTAGCCTACCTATAAGGGATTGAAAC	AGTCAATGGCTTTGGCTCTAGCAGAGCCTTTCTCTTCAC
GTTTTTAGCCTACCTATAAGGGATTGAAAC	CGATATGGCGGTATCTCAAGTGGCAGAGGTTGCAATA
GTTTTTAGCCCACCTATAAGGGATTGAAAC	ATTGAATCCATATTCTTTTTTCGAGGGACAAAATCGAA
GTTTTTAGCCTACCTATAAGGGATTGAAAC

>NC_014377|5|4|544868-545235|PILER-CR
GTTTTTAGCCTACCTATAAGGGATTGAAAC	AGATCGTAGCGGCGACAATAGCAAGAAACTGGTCGA
GTTTTTAGCCTACCTATAAGGGATTGAAAC	ATGGATAAGATTTATAGACTTCAGAATGGGGAAATTAC
GTTTTTAGCCTACCTATAAGGGATTGAAAC	AGTCAATGGCTTTGGCTCTAGCAGAGCCTTTCTCTTCAC
GTTTTTAGCCTACCTATAAGGGATTGAAAC	CGATATGGCGGTATCTCAAGTGGCAGAGGTTGCAATA
GTTTTTAGCCCACCTATAAGGGATTGAAAC	ATTGAATCCATATTCTTTTTTCGAGGGACAAAATCGAA
GTTTTTAGCCTACCTATAAGGGATTGAAAC

>NC_014377|5|5|544868-545300|CRISPRCasFinder
GTTTTTAGCCTACCTATAAGGGATTGAAAC	AGATCGTAGCGGCGACAATAGCAAGAAACTGGTCGA
GTTTTTAGCCTACCTATAAGGGATTGAAAC	ATGGATAAGATTTATAGACTTCAGAATGGGGAAATTAC
GTTTTTAGCCTACCTATAAGGGATTGAAAC	AGTCAATGGCTTTGGCTCTAGCAGAGCCTTTCTCTTCAC
GTTTTTAGCCTACCTATAAGGGATTGAAAC	CGATATGGCGGTATCTCAAGTGGCAGAGGTTGCAATA
GTTTTTAGCCCACCTATAAGGGATTGAAAC	ATTGAATCCATATTCTTTTTTCGAGGGACAAAATCGAA
GTTTTTAGCCTACCTATAAGGGATTGAAAC	TATTCTCTTGCAGGGATATCGATTTGTGCCACATA
GTTTTTAGCCTACCTATCCTGAAAATAATG

Protein	Signature genes	Signature genes Name	Protein_function
NC_014377.1\|WP_013275351.1\|537032_537992_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm4	csm4gr5	cd09663_csm4gr5_CAS-III-A	gnl\|CDD\|187794
NC_014377.1\|WP_148218371.1\|543529_544794_+\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|366234
NC_014377.1\|WP_041423837.1\|553590_554622_-\|PTS-fructose-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|224218
NC_014377.1\|WP_041423838.1\|554643_554955_-\|PTS-fructose-transporter-subunit-IIB	unknown	unknown	gnl\|CDD\|224362
NC_014377.1\|WP_013275362.1\|550908_553539_-\|alpha-mannosidase	unknown	unknown	gnl\|CDD\|182093
NC_014377.1\|WP_013275353.1\|539131_539812_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	mkCas0062_cas6_CAS-I:CAS-III	gnl\|CDD\|273848
NC_014377.1\|WP_041423836.1\|536192_537026_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm3	csm3gr7	cd09684_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|187815
NC_014377.1\|WP_013275360.1\|548717_550418_+\|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|274171
NC_014377.1\|WP_013275358.1\|546343_546856_+\|NADH-quinone-oxidoreductase-subunit-NuoE	unknown	unknown	gnl\|CDD\|376507
NC_014377.1\|WP_013275352.1\|538004_539126_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm5	csm5gr7	cd09662_csm5gr7_CAS-III-A	gnl\|CDD\|187793
NC_014377.1\|WP_013275354.1\|539812_541177_+\|TIGR01897-family-CRISPR-associated-protein	csx1	cd09728_csx1_CAS-III	gnl\|CDD\|273862
NC_014377.1\|WP_013275363.1\|555411_557379_-\|transcription-antiterminator	unknown	unknown	gnl\|CDD\|226234
NC_014377.1\|WP_013275348.1\|533389_535756_+\|type-III-A-CRISPR-associated-protein-Cas10/Csm1	cas10	cd09680_cas10_CAS-III	gnl\|CDD\|187811
NC_014377.1\|WP_041423839.1\|554951_555422_-\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|334031
NC_014377.1\|WP_013275359.1\|546839_548717_+\|NADH-quinone-oxidoreductase-subunit-NuoF	unknown	unknown	gnl\|CDD\|224806
NC_014377.1\|WP_013275349.1\|535769_536192_+\|type-III-A-CRISPR-associated-protein-Csm2	csm2gr11	pfam03750_csm2gr11_CAS-III-A	gnl\|CDD\|367635
NC_014377.1\|WP_013275364.1\|557516_557846_-\|nucleotidyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|143393
NC_014377.1\|WP_013275361.1\|550490_550862_-\|Fe-S-cluster-assembly-scaffold-protein-NifU	unknown	unknown	gnl\|CDD\|132460
NC_014377.1\|WP_013275355.1\|541216_541501_+\|CRISPR-associated-protein-Csx3	csx3	cd09681_csx3_CAS-I:CAS-III	gnl\|CDD\|370583
NC_014377.1\|WP_013275347.1\|532815_533178_+\|nucleotidyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|143393

Protein	Function_ID	Function_description	E-value
NC_014377.1\|WP_013275351.1\|537032_537992_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm4	gnl\|CDD\|187794	cd09663, Csm4_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm4. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein.	1.32094e-60
NC_014377.1\|WP_148218371.1\|543529_544794_+\|IS3-family-transposase	gnl\|CDD\|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	3.81293e-23
NC_014377.1\|WP_041423837.1\|553590_554622_-\|PTS-fructose-transporter-subunit-IIC	gnl\|CDD\|224218	COG1299, FruA, Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism].	1.0302e-99
NC_014377.1\|WP_041423838.1\|554643_554955_-\|PTS-fructose-transporter-subunit-IIB	gnl\|CDD\|224362	COG1445, FrwB, Phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism].	4.81986e-38
NC_014377.1\|WP_013275362.1\|550908_553539_-\|alpha-mannosidase	gnl\|CDD\|182093	PRK09819, PRK09819, mannosylglycerate hydrolase.	0
NC_014377.1\|WP_013275353.1\|539131_539812_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	2.08704e-11
NC_014377.1\|WP_041423836.1\|536192_537026_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm3	gnl\|CDD\|187815	cd09684, Csm3_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein.	2.91366e-76
NC_014377.1\|WP_013275360.1\|548717_550418_+\|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein	gnl\|CDD\|274171	TIGR02512, Periplasmic_hydrogenase_large_subunit, [FeFe] hydrogenase, group A. This model describes iron-only hydrogenases of anaerobic and microaerophilic bacteria and protozoa. This model is narrower, and covers a longer stretch of sequence, than pfam02906. This family represents a division among families that belong to pfam02906, which also includes proteins such as nuclear prelamin A recognition factor in animals. Note that this family shows some heterogeneity in terms of periplasmic, cytosolic, or hydrogenosome location, NAD or NADP dependence, and overal protein protein length.	0
NC_014377.1\|WP_013275358.1\|546343_546856_+\|NADH-quinone-oxidoreductase-subunit-NuoE	gnl\|CDD\|376507	pfam01257, 2Fe-2S_thioredx, Thioredoxin-like [2Fe-2S] ferredoxin.	2.84888e-75
NC_014377.1\|WP_013275352.1\|538004_539126_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm5	gnl\|CDD\|187793	cd09662, Csm5_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein.	1.05984e-27
NC_014377.1\|WP_013275354.1\|539812_541177_+\|TIGR01897-family-CRISPR-associated-protein	gnl\|CDD\|273862	TIGR01897, hypothetical_protein, CRISPR-associated protein, MJ1666 family. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This model describes a Cas protein about 400 residues in length, found mostly in the Archaea but also in Aquifex.	2.50221e-36
NC_014377.1\|WP_013275363.1\|555411_557379_-\|transcription-antiterminator	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	1.15048e-62
NC_014377.1\|WP_013275348.1\|533389_535756_+\|type-III-A-CRISPR-associated-protein-Cas10/Csm1	gnl\|CDD\|187811	cd09680, Cas10_III, CRISPR/Cas system-associated protein Cas10. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Multidomain protein with permuted HD nuclease domain, palm domain and Zn-ribbon; signature gene for type III; also known as Csm1 family.	8.40269e-119
NC_014377.1\|WP_041423839.1\|554951_555422_-\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|334031	pfam00359, PTS_EIIA_2, Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2.	3.32097e-49
NC_014377.1\|WP_013275359.1\|546839_548717_+\|NADH-quinone-oxidoreductase-subunit-NuoF	gnl\|CDD\|224806	COG1894, NuoF, NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion].	0
NC_014377.1\|WP_013275349.1\|535769_536192_+\|type-III-A-CRISPR-associated-protein-Csm2	gnl\|CDD\|367635	pfam03750, Csm2_III-A, Csm2 Type III-A. Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-associated) proteins. This entry represents Csm2 Type III-A, a family of Cas proteins also known as TM1810/Csm2.	3.0031e-31
NC_014377.1\|WP_013275364.1\|557516_557846_-\|nucleotidyltransferase-domain-containing-protein	gnl\|CDD\|143393	cd05403, NT_KNTase_like, Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins. S. aureus KNTase is a plasmid encoded enzyme which confers resistance to a wide range of aminoglycoside antibiotics which have a 4'- or 4''-hydroxyl group in the equatorial position, such as kanamycin A. This enzyme transfers a nucleoside monophosphate group from a nucleotide (ATP,GTP, or UTP) to the 4'-hydroxyl group of kanamycin A. This enzyme is a homodimer, having two NT active sites. The nucleotide and antibiotic binding sites of each active site include residues from each monomer. Included in this subgroup is Escherichia coli AadA5 which confers resistance to the antibiotic spectinomycin and is a putative aminoglycoside-3'-adenylyltransferase. It is part of the aadA5 cassette of a class 1 integron. This subgroup also includes Haemophilus influenzae HI0073 which forms a 2:2 heterotetramer with an unrelated protein HI0074. Structurally HI0074 is related to the substrate-binding domain of S. aureus KNTase. The genes encoding HI0073 and HI0074 form an operon. Little is known about the substrate specificity or function of two-component NTs. The characterized members of this subgroup may not be representive of the function of this subgroup. This subgroup belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, co-ordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are conserved in this subgroup.	6.652e-09
NC_014377.1\|WP_013275361.1\|550490_550862_-\|Fe-S-cluster-assembly-scaffold-protein-NifU	gnl\|CDD\|132460	TIGR03419, NifU_clost, FeS cluster assembly scaffold protein NifU, Clostridium type. NifU and NifS form a pair of iron-sulfur (FeS) cluster biosynthesis proteins much simpler than the ISC and SUF systems. Members of this protein family are a distinct group of NifU-like proteins, found always to a NifS-like protein and restricted to species that lack a SUF system. Typically, NIF systems service a smaller number of FeS-containing proteins than do ISC or SUF. Members of this particular branch typically are found, almost half the time, near the mnmA gene, involved in the carboxymethylaminomethyl modification of U34 in some tRNAs (see GenProp0704). While other NifU proteins are associated with nitrogen fixation, this family is not. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	2.14848e-65
NC_014377.1\|WP_013275355.1\|541216_541501_+\|CRISPR-associated-protein-Csx3	gnl\|CDD\|370583	pfam09620, Cas_csx3, CRISPR-associated protein (Cas_csx3). This entry is encoded in CRISPR-associated (cas) gene clusters, near CRISPR repeats, in the genomes of several different thermophiles: Archaeoglobus fulgidus (archaeal), Aquifex aeolicus (Aquificae), Dictyoglomus thermophilum (Dictyoglomi), and a thermophilic Synechococcus (Cyanobacteria). It is not yet assigned to a specific CRISPR/cas subtype (hence the x designation csx3).	6.84438e-41
NC_014377.1\|WP_013275347.1\|532815_533178_+\|nucleotidyltransferase-domain-containing-protein	gnl\|CDD\|143393	cd05403, NT_KNTase_like, Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins. S. aureus KNTase is a plasmid encoded enzyme which confers resistance to a wide range of aminoglycoside antibiotics which have a 4'- or 4''-hydroxyl group in the equatorial position, such as kanamycin A. This enzyme transfers a nucleoside monophosphate group from a nucleotide (ATP,GTP, or UTP) to the 4'-hydroxyl group of kanamycin A. This enzyme is a homodimer, having two NT active sites. The nucleotide and antibiotic binding sites of each active site include residues from each monomer. Included in this subgroup is Escherichia coli AadA5 which confers resistance to the antibiotic spectinomycin and is a putative aminoglycoside-3'-adenylyltransferase. It is part of the aadA5 cassette of a class 1 integron. This subgroup also includes Haemophilus influenzae HI0073 which forms a 2:2 heterotetramer with an unrelated protein HI0074. Structurally HI0074 is related to the substrate-binding domain of S. aureus KNTase. The genes encoding HI0073 and HI0074 form an operon. Little is known about the substrate specificity or function of two-component NTs. The characterized members of this subgroup may not be representive of the function of this subgroup. This subgroup belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, co-ordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are conserved in this subgroup.	8.05559e-15

>NC_014377.1|WP_148218371.1|543529_544794_+|IS3-family-transposase
MKKKRYDREFKEQVVRECQEVGNIALVARRHGLSKNTVYNWLQATRKNGSVIPLPRDVNQRLLEAENRLESLARENDQLKRLVAEKELELAILRELRDRVNPPVADKVAIAKRWVAKGYSLYLVLGFVGLAPSTFYAYESKKEPTVTADNQAKAKAGRPKTQFSYTLDGKKVADEQIKEWLCELVCQDGFPYGYKKLTAALVEDYGLVINHKKVYRLCKELDILKPQRICKSKHPRRLAQRIEVTGPNQLWEMDVKYGYIHGEERFFFQLSLIDVFDRCVIDYHLGLTCTAKDARRVLCNALKKRGIKPGMQMPRLRTDNGPQFIANLFAAACRKLGIVHERIPVKTPNLNAHIEAFHSILEDECYSRHQFASYAEAYEQIAWYMDYYNNRRRHGSLNNMAPQKYYQAIISNSIKPKSLVA
>NC_014377.1|WP_013275355.1|541216_541501_+|CRISPR-associated-protein-Csx3
MVKFDTAEYGKYTILHFELEGPINPEILKDICPPKVNSTKGLIISGRGPIWLYCYLVHYYHFTVFIATFDPRLGGAVIVESHIPEFKPGNVIML
>NC_014377.1|WP_013275354.1|539812_541177_+|TIGR01897-family-CRISPR-associated-protein
MNSLIYQIGRLDRNIIKKQKFTIEGKTRSKQLSSFALKEHLKENGEQAKVILVYPVSLPFNRTLENANFGDFSRSLKAVLRNPKEEYLSNPKNFFSNMPYSSEVDDFIVIHSIGEYAGINFQGKFNDIVFEIALDMIERYNEEIERIYVDISSGLNIYVSALLEAVRFFSIWATLKNWLPEAKRPEIWITFSDPILDNEAAEYQLHREKLEFKAFFASPINKEDINNVAKKIYEDDRSKKRKLSSLLENFLVIFSAIKNNIPLAVYLFGYEDGEVIDETSRTLIEDMKKKLYDSYAASPNLDKNTYSKGLLSLAFYSGIAEVFWHYQIKNHDEDDGIDLDELKRIFDDLYSLFSLKPNNVFLGNEISNTKRIMGKINIEDSTWHLLIKFHNKEYEGRTPDKRNFFAHSGLEGLVTEMKKEKDKFFVRYTREYTDKSGNKKSVKNLIREWLKEEA
>NC_014377.1|WP_013275353.1|539131_539812_+|CRISPR-associated-endoribonuclease-Cas6
MFRLRLEIYFKKDAFFFDRGYKINLSSYFREVIKNQFFVFSDIIPSKKKPAKDGFWALDRAALILNTAFQELLPDIALKIMNTPVDFRYGRLTFSKAIFQRVPLERTGYLLSPVAVALPAGENLLWEERPERFSEALRQMLVDKYIRLYGRRPSDDRFLFRFRGRPVKEELDSGVIAYRGKFEIFSSEELVMLSYLCGLGSFNAMGYGMASPDLYLWKKPETMEGI
>NC_014377.1|WP_013275352.1|538004_539126_+|type-III-A-CRISPR-associated-RAMP-protein-Csm5
MEKPFQYEVEIISPVNIGDGNRYREFEYIIEGDSIGFIDVIKLLKSNKDNTSFIDYFYRSIDSFRFSWQDALKYAPKIDISEFISYQVKPCGASRVKGDIVSFIKTTGYPYIPGSSLKGSFRTGLMRGVWPSIEEEYKAKLDDTLREKDKKLKEIDDYPEEETFGKPHYSPFKFVRFSDSSLLPLDALGIYEMKILNICHGKAKWFKKNENVEESENATAIYIEALKPGIRAEGFFEIKQRTKNEEIYRIIKNVWILKNAFNAIRNDTKRYIEGEKYFYKEYGLDQVANFYQRLEELNGKLGENEILLQIGFGTGYLSKTIGCFLSAEDLKKLSKQGVRISDANLFPKTRRIIFANGNPDTVPGWVKITFREV
>NC_014377.1|WP_013275351.1|537032_537992_+|type-III-A-CRISPR-associated-RAMP-protein-Csm4
MDSGVKRYRVKLKFKGPVHFGYKEKTYNLTETFAHSDTLFSGIVNCYSLLYGKAAADNLVEMFFDNPPFKISSAFLYANDEFFVPRPLNMDLTPITGDYKKAKKVKYVPLDFILARDGGGKANKDYRVEHGILARKDMDTPYVISERPRVKIDRGDFSTEIYYVSGCYFREGAGLWFFLDIYDDSEEEKVKAAIRLLGDEGIGGERTYGFGSFEAGIEEYNEKKGNGSGDWLLLSLYYPRMDEKVADIIKAFSLLERAGYSYSPFNQQARKKKVRMLAEGSVFKKDVQGMVVDVSPGEDVGHKILKYGLAYTVPIFNRK
>NC_014377.1|WP_041423836.1|536192_537026_+|type-III-A-CRISPR-associated-RAMP-protein-Csm3
MEVDFVKDLKLAGKYIITSEIVALTGLHIGTSSNTLEIGGVDNSVVKDALGRPYIPGSSLKGKMRALLEYAEGLITMVYVVHNERNESSNTRIHMCKKEDCAVCNIFGRNHGKHKVVDGNDPRGYRPVDFTDAVTPTRLIVRDATLIKESITEQMKENMDFEWTEVKFENNLDRVTSAANPRQTERVPAGARFKSEMVLTVFQGEGTKYIEKLLEAMLLLEDDYLGGQGTRGYGRIAFEKVSIAFRSVGYYEGREEEQVIVENCPSLREALGKIKRG
>NC_014377.1|WP_013275349.1|535769_536192_+|type-III-A-CRISPR-associated-protein-Csm2
MAWESNRKGKSDSFNDVKEIEERLPSALDKNKDPNGDDFFYCAEKTGKLLATKRVSVSQIRKIFNKARRIKYEENGIFELRMLKAVIAYTAGRFPENMKEFKGIFTKAIEIAEKSEENLKRFKQFFEAVVAYHRSYGGRE
>NC_014377.1|WP_013275348.1|533389_535756_+|type-III-A-CRISPR-associated-protein-Cas10/Csm1
MAFLFNDFTAEERNLLLAALLHDIGKFWQRTQDEPMRRIVSENYRAFYEARNHSSPGHQDWSAYFCETFVKIREVTNAVINHHGPSERLHYFVSAGDCLSAGERLDIAEEKGGEIRQLVSILSCIELDGLRSKKAYYKKLVPLGEYCVPEEEPSPNPKQGYKELWDAFIKAFNSIQNFDDPVELTKLYSILEEYTFNIPSAYYYSMPDISLWAHLKTAAAIAFALYRELEGKPNQHVISKLDSIIRRPSAVEEDLFCLVKGDISGIQDFVYDTKMDGATKALRGKSFYLSYLMTVIPKYILKKERLPITNLLYSGGGHFYLIMHGRFLQKLDEYQKELDGLFLDAHHGELALLLKGVTLKPADFRVKDGKLPEKFEELGKLLQEEKNRKFYSILKEDQKMVFGPFKEKGEPCPHCGNPVKEDECPFCRSFERLGENLIKKKFLVEEWKEKSERQKGSIEKVEDIFKRLGVSVEFTDEALEKDYSFAVKREEWDFKKCCGYMKIPVGMKLDQKGNIITFDEISDSAKGIKVWGVLRGDVDNLGRIFREGLGQNRSFARIMTLSQEMAQFFGPSLERMLNRLGSCDKSHSYENCAVIYAGGDDFFLVGPWDAMPYVAEEIKKEFYRYTGHNPAITVSMAFDIAPDKKFPLYRVAQTAGENLENAKHFKDPVRKKEKNCFAFAGVPIGWEDFDKFKDVKEKLFKALDELKVSRSLLGIIYRVCREYEVSANEDGKMFRSWRLFYYVARLKERNKKAEDILDKLIYLLIEKGNKLYKYAFQSARWAEFETRK
>NC_014377.1|WP_013275347.1|532815_533178_+|nucleotidyltransferase-domain-containing-protein
MPVRSLNSSVLKWPDKETVVYSLLEWVKEITQNRNDIVKIGYFGSYARGDWGVGSDLDIIIIVKKSDIPFNNRSAEWDTKGIPIPVDLLVYTVEEYENMKAMNSGFSKSIEKEVVWIYPL
>NC_014377.1|WP_013275358.1|546343_546856_+|NADH-quinone-oxidoreductase-subunit-NuoE
MATATGHGRSFQRVDEIIEAHGRNPVNIISILQEVQNEYRYLPQDVLNYIATAMNISPSKVYGVATFYENFSLEPKGKYVIRICDGTACHVKNSTALLNALTKKLGLKEGQRTTEDLLFTLETVSCLGACGLAPVMVVNEEVHGKVTPEKAEEIIDEIINKERGQNDKER
>NC_014377.1|WP_013275359.1|546839_548717_+|NADH-quinone-oxidoreductase-subunit-NuoF
MIKSVEELNKLKDECSKALAGEKMKILVCAGTGCISGGSLKVYEAIKKLLEEKNLYVDIDLYTEDKEGVNVSPSGCHGFCQMGPIVRVEPQGYFYVKVKEEDAQEIVEKTVEKGEPVERLLYKSHEDGQAFMTEDSIPFYGKQSRIVLEHCGKINPENIKEYIAAGGYQALAKALQMTPEEICQVMLKAKLRGRGGAGFPAGIKWDSVRKQKSDVKYVICNGDEGDPGAFMDRSIMEGDPHRVIEGMIIAGYASGATQGYIYVRAEYPLAVRRLKKAIEQAREFGLLGKNILGSGFDFDIKINMGAGAFVCGEGSALIASIEGQRGMPKTRPPRTVEKGLFGKPTVLNNVETYANVPMIILNGADWYLSIGTETSPGTKAFALTGNIVNTGLIEVPMGTTLREVIYEIGGGIPNGKELKAVQIGGPSGGCLTKEHLDLPLDFDTLGTVGAMIGSGGMVVMDEDTCMVEVARFFMSFTQRESCGKCVPCREGTKRMLKLLEKITSGKGTEKDLELLEELAVTVKDGSLCGLGQTAPNPVLTTLKYFRDEYLAHVREKRCPAGVCQALKRYAIDATVCKGCSKCSRVCPVGAISGEIKKPFTINPDKCIKCGACVEACPFKAVKEGK
>NC_014377.1|WP_013275360.1|548717_550418_+|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein
MKTLKINGREVAFSDEKNLLEVIRKAGIELPTFCYHSELSTYGACRMCLVEDKRGNLIAACSTPPREGMEIKTHTKRLLKQRRMTLELILAEHDRDCTTCGKNGDCKLRKLSHDLGVEEIRFGTKENYLPIDDSSEAIVRNPNKCILCGDCVRMCEEVQGIGVIGFAHRGAKAVVTPAFNKNLCEVECVDCGQCSAVCPTGAIVVKSHIDKVWDALNDDNKVVIAQIAPAVRVAFGEAFGLRPGESTEYLIVSALKAMGFDMVFDTCFAADLTVIEEGHEFLERLEKGENLPLFTSCCPAWVKFVEFNYPSFLNNLSSCRSPHQMFGSFTKNYYAKELGVSRENVYVVSIMPCTAKKAEAAREELGVDGNPDVDAVLTTRELIRMVREAGIVFKDLKEEPFDMPFGFSTGGGIIFGATGGVAEAVVRTLDGGHRRFEQVRGSEGLKEATIVKDGKEIRVAVVHGLKNARELLEKIKSGSVKYDMVEVMACPGGCVGGAGQPSPASTGVREERAKGLYNIDNRMQLARSDENPMIKMLYEKWLGSPGSEVAHKYLHTHYRPRRRTEV
>NC_014377.1|WP_013275361.1|550490_550862_-|Fe-S-cluster-assembly-scaffold-protein-NifU
MYNEKVLDHFSNPRNAGEIPDADGIGHAGNPVDGDSITIYIKVKDGIIDDIKFKTFGCGAAIAASSMLTVLAKGKTLDEALKITNDQVAEALGGLPPQKLNCSNIAADALHDAIADYKNKISR
>NC_014377.1|WP_013275362.1|550908_553539_-|alpha-mannosidase
MNLYVVCHTHWDREWHKTFHEYRVKLVEFMDDLIDLLERDENYTSFLLDGQTVVLEDYLDVKPYMKERIRRLVKAGRLVIGPWYVQPDEFLVSGESLIRNLLIGHEIGKDFGRVMKVGYLPDSFGQAACIPQLLKGFGIDSAVFWRGVTDEDLDKTEFLWESPDGSRVFAVHLPLGYGNGASLSKNMAMSFETVEENLKKLASKAATNNILLMCGFDQRFADHDIPEIIKELNSYYKENGKDIRLIQCSIEDYIEKVKSEEPSLKVLKGEFRKGKSMRVHVSIGGTRLDIKRDNFNTQLLYERYLEPISTMAYILGHKYDNDIINRGWKYIIQNHAHDSICTVCTDDTHREMKIRFEFAKQIGHTLLNEKISEISGDIAYKKEMGKPLIVFNTLMRKRKEPVEATIYLDTEEFSLTDNEGRKIPYQIMSVKDVNLAEKEIEIGVKNPDRWVKEIKLVFIAELDGFGYRTYYVKEHAKSNRYTGFIGAGNILENEFYRVSVEDDGSLCITDKETAKTYRGLNIFEESGNAGDEYDFSPPKEDVVITTRGSRPEIALVENGPLFARIRISHILNVPMDTDSMKRAEKTCPCPVDCFVTLYRGIKRVDIKTVIDNRAKNHRIRVLFDGNVEAHTHIAEQQFGVLKRDNFLKEQECWDKEGWEERYYPVYPQRSFVDVSDGQYGLAILNKGLPQYEILNKDKPIIALTLLSGTDYMGKNDLRYRPGRRSGLHIAVPDSQLLGVHEVEYSIVPHKGDYIAGDIIESAHSYITPLLSFMPLNETQGELNDELYFIKTENKGIIESSIKKSEHGPAVVLRIYNGTDLPLRNIVLKLDDRFNAVDILDLKEEKIKNNNKVSFVENKINIPLLNENEIISLSLGR
>NC_014377.1|WP_041423837.1|553590_554622_-|PTS-fructose-transporter-subunit-IIC
MNNKIWENARRHLMTGVSYMIPFVVSGGLLLTIGILIGGGKVIPGMSKTLVDLGVTAFQMMVPIMAGYMAYSMADRPGIAPGIVGGLIANKIGAGFLGGIVAGFIAGWVVNQLKRIPLHPYIAPLKPIIIIPFFGVGIVAGLMLIIGQPISALSKTLEAWLNSMTGANAALLGFIIAAMMAFDMGGPVNKIAFAFSAGMLSQGVYAPMAACWVGIMAPPMGLALATYLAPKKFTEVERKNAIPAAIMGATGITEGAIPYAAADPLRVIPSLVIGSGFGGAVALLLGAQAPVPSGGVFVIPFFIKPLMFVIGFAAAIIVTALITVALKKEVTEEENNFEGLNLE
>NC_014377.1|WP_041423838.1|554643_554955_-|PTS-fructose-transporter-subunit-IIB
MKIVAVTACPSGVAHTYMAATALKKAAKANGAQIKIETQGALGIENEITEKEAREADAVILAIETAIAKPERFKNKPVIQVPVSEAIKDADAIIKKAMSLISK
>NC_014377.1|WP_041423839.1|554951_555422_-|PTS-sugar-transporter-subunit-IIA
MIIKDILKRELIELNMGAKTKEEVINEMADMLFKSGAITSKEAFVKDVFERERIGTTGVGMGIAIPHGRSGSVINTSVAIAKLKEPVDWDSLDGKPVSLVFLLAVPKDGGENIHLKLLSGIASMLMEEDFREKLFKASDKEEVLNIMGFVKEDDLK
>NC_014377.1|WP_013275363.1|555411_557379_-|transcription-antiterminator
MDLDARKKKIIEELLISKGPVTGEYLAGVLGVSSRTIRSDIKIINEQLKESGIKIISSPGVGYSLEYDDEEKLSGILREIMKESQGYIVPTLPEDRVRYIRGKLLAADGFITLESLADELYVSKSTVEKDMEKVEEWFSSHNIKIFKKPNYGMKLQGSEMDLRFAMSDHLRSLKDEKVFAVDLPDIGDIVKDVDIEVIKDVIDEVLERIPFKLSDVAYTNLIIHIAIAVKRIRESKSIELPPGEITNLKDKMEYSVAADMVKSLESKFNISIPEAEIGYITMHLMGTKVLEDGSLSKEKIKKAVGEEIYRVATRMIEEVKRVYGIDFTADDELIYGLALHLKPTITRIKYGMNLKNPLLKEIKEEYPQAFELAVVASRVLEDVYKIKVDENEMGYIAVYFGAAIERGNYRESNQIKRVAVVCASGMGTAQLLATRIRKTFPNITITGVYPAFKSSEIIKQRPDFILSTVPLENMDIPVIEISPLLNKNDLRRLKAVILSEDEDVDRSILLKFMKEDLFFKGISASDCFEVIDKMSDSLYQKGYVTKGFKESAKQREKISSTGIGNLVAIPHAMLGHAIGSHIAVGILEKPIKWGSSQAQLIFMIALEKLSDREFQHIFEALYDVVDDPSLVAKLIKARDFNEFARILKGRGRYDN
>NC_014377.1|WP_013275364.1|557516_557846_-|nucleotidyltransferase-domain-containing-protein
MVKTKDEIMKIVRDYICNLGKYIKINKVILFGSYARDEALKSSDVNLAIVSEDFGKMSFFERLELLYKCWNYDIGADLLGYTPEEFEELANKISFVSEIIKTGIEITPA

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Crispr_ID: NC_014377_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014377_6

887820-887926

Orphan

Consensus_repeat	Method
TGATTCCTGTACTGATTATAGTTCGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014377_6

>merge|NC_014377|6|887820-887926|CRISPRCasFinder
TGATTCCTGTACTGATTATAGTTCGACCTGACCGGTGTCATCGCCTGAGTGGTATGCTGCCCGTATTCCTGGTTGTAAGCCTGATTCCTGTACTGATTGTAGTTCGA

>NC_014377|6|6|887820-887926|CRISPRCasFinder
TGATTCCTGTACTGATTATAGTTCGA	CCTGACCGGTGTCATCGCCTGAGTGGTATGCTGCCCGTATTCCTGGTTGTAAGCC
TGATTCCTGTACTGATTGTAGTTCGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_014377.1\|WP_013275701.1\|886645_887656_+\|DNA-polymerase-III-subunit-delta	unknown	unknown	gnl\|CDD\|235511
NC_014377.1\|WP_013275698.1\|882690_883485_+\|sugar-phosphate-isomerase/epimerase	unknown	unknown	gnl\|CDD\|224007
NC_014377.1\|WP_148218447.1\|890335_891385_+\|stage-II-sporulation-protein-P	unknown	unknown	gnl\|CDD\|377838
NC_014377.1\|WP_013275696.1\|881101_881638_-\|hypothetical-protein	unknown	unknown	unknown
NC_014377.1\|WP_013275709.1\|893680_894805_+\|oxygen-independent-coproporphyrinogen-III-oxidase	unknown	unknown	gnl\|CDD\|180263
NC_014377.1\|WP_041423860.1\|889202_890174_+\|GPR-endopeptidase	unknown	unknown	gnl\|CDD\|237076
NC_014377.1\|WP_013275697.1\|881939_882653_+\|DNA-alkylation-repair-protein	unknown	unknown	gnl\|CDD\|378033
NC_014377.1\|WP_013275707.1\|891462_891831_+\|hypothetical-protein	unknown	unknown	unknown
NC_014377.1\|WP_013275693.1\|879560_879764_+\|hypothetical-protein	unknown	unknown	unknown
NC_014377.1\|WP_013275712.1\|896825_898412_+\|TCP-1/cpn60-chaperonin-family-protein	unknown	unknown	gnl\|CDD\|365887
NC_014377.1\|WP_013275695.1\|880634_880997_-\|zinc-ribbon-domain-containing-protein	unknown	unknown	gnl\|CDD\|379915
NC_014377.1\|WP_013275710.1\|894815_895691_+\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638
NC_014377.1\|WP_013275700.1\|884239_886558_+\|DNA-internalization-related-competence-protein-ComEC/Rec2	unknown	unknown	gnl\|CDD\|273036
NC_014377.1\|WP_013275704.1\|888866_889193_+\|phage-holin-family-protein	unknown	unknown	gnl\|CDD\|377198
NC_014377.1\|WP_013275703.1\|888471_888744_-\|30S-ribosomal-protein-S20	unknown	unknown	gnl\|CDD\|376586
NC_014377.1\|WP_013275699.1\|883566_884055_+\|ADP-ribosylglycohydrolase-family-protein	unknown	unknown	gnl\|CDD\|377122
NC_014377.1\|WP_013275694.1\|879882_880638_+\|4-hydroxy-tetrahydrodipicolinate-reductase	unknown	unknown	gnl\|CDD\|234595
NC_014377.1\|WP_013275692.1\|878532_879516_+\|biotin--[acetyl-CoA-carboxylase]-ligase	unknown	unknown	gnl\|CDD\|223417
NC_014377.1\|WP_013275708.1\|891872_893675_+\|elongation-factor-4	unknown	unknown	gnl\|CDD\|235462
NC_014377.1\|WP_013275711.1\|895776_896808_+\|heat-inducible-transcription-repressor-HrcA	unknown	unknown	gnl\|CDD\|234621

Protein	Function_ID	Function_description	E-value
NC_014377.1\|WP_013275701.1\|886645_887656_+\|DNA-polymerase-III-subunit-delta	gnl\|CDD\|235511	PRK05574, holA, DNA polymerase III subunit delta; Reviewed.	2.82165e-52
NC_014377.1\|WP_013275698.1\|882690_883485_+\|sugar-phosphate-isomerase/epimerase	gnl\|CDD\|224007	COG1082, IolE, Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism].	8.20982e-31
NC_014377.1\|WP_148218447.1\|890335_891385_+\|stage-II-sporulation-protein-P	gnl\|CDD\|377838	pfam07454, SpoIIP, Stage II sporulation protein P (SpoIIP). This family contains the bacterial stage II sporulation protein P (SpoIIP) (approximately 350 residues long). It has been shown that a block in polar cytokinesis in Bacillus subtilis is mediated partly by transcription of spoIID, spoIIM and spoIIP. This inhibition of polar division is involved in the locking in of asymmetry after the formation of a polar septum during sporulation. Engulfment in Bacillus subtilis is mediated by two complementary systems: the first includes the proteins SpoIID, SpoIIM and SpoIIP (DMP) which carry out the engulfment, and the second includes the SpoIIQ-SpoIIIAGH (Q-AH) zipper, that recruits other proteins to the septum in a second-phase of the engulfment. The course of events follows as the incorporation firstly of SpoIIB into the septum during division to serve directly or indirectly as a landmark for localising SpoIIM and then SpoIIP and SpoIID to the septum. SpoIIP and SpoIID interact together to form part of the DMP complex. SpoIIP itself has been identified as an autolysin with peptidoglycan hydrolase activity.	4.70409e-84
NC_014377.1\|WP_013275692.1\|878532_879516_+\|biotin--[acetyl-CoA-carboxylase]-ligase	gnl\|CDD\|223417	COG0340, BirA, Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism].	4.85161e-82
NC_014377.1\|WP_013275709.1\|893680_894805_+\|oxygen-independent-coproporphyrinogen-III-oxidase	gnl\|CDD\|180263	PRK05799, PRK05799, oxygen-independent coproporphyrinogen III oxidase.	8.84908e-171
NC_014377.1\|WP_041423860.1\|889202_890174_+\|GPR-endopeptidase	gnl\|CDD\|237076	PRK12362, PRK12362, germination protease; Provisional.	0
NC_014377.1\|WP_013275697.1\|881939_882653_+\|DNA-alkylation-repair-protein	gnl\|CDD\|378033	pfam08713, DNA_alkylation, DNA alkylation repair enzyme. Proteins in this family are predicted to be DNA alkylation repair enzymes. The structure of a hypothetical protein in this family shows it to adopt a supercoiled alpha helical structure.	1.08273e-69
NC_014377.1\|WP_013275695.1\|880634_880997_-\|zinc-ribbon-domain-containing-protein	gnl\|CDD\|379915	pfam17032, zinc_ribbon_15, zinc-ribbon family. This zinc-ribbon region is found on a set of largely microsporidia-specific proteins.	8.96835e-19
NC_014377.1\|WP_013275710.1\|894815_895691_+\|RluA-family-pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	3.19406e-92
NC_014377.1\|WP_013275700.1\|884239_886558_+\|DNA-internalization-related-competence-protein-ComEC/Rec2	gnl\|CDD\|273036	TIGR00361, Recombination_protein_2, DNA internalization-related competence protein ComEC/Rec2. Apparant orthologs are found in 5 species so far (Haemophilus influenzae, Escherichia coli, Bacillus subtilis, Neisseria gonorrhoeae, Streptococcus pneumoniae), of which all but E. coli are model systems for the study of competence for natural transformation. This protein is a predicted multiple membrane-spanning protein likely to be involved in DNA internalization. In a large number of bacterial species not known to exhibit competence, this protein is replaced by a half-length N-terminal homolog of unknown function, modelled by the related model ComEC_N-term. The role for this protein in species that are not naturally transformable is unknown. [Cellular processes, DNA transformation].	5.46971e-84
NC_014377.1\|WP_013275704.1\|888866_889193_+\|phage-holin-family-protein	gnl\|CDD\|377198	pfam04020, Phage_holin_4_2, Mycobacterial 4 TMS phage holin, superfamily IV. These proteins are predicted transmembrane proteins with probably four transmembrane spans. The 1.E.40 is represented by the mycobacterial 4 phage holin, but it also contains many cyanobacterial. proteobacterial and firmicute proteins. Holins are encoded within the genomes of Gram-positive and Gram-negative bacteria as well as in those of the bacteriophage of these organisms. The primary function of holins appears to be transport of murein hydrolases across the cytoplasmic membrane to the cell wall where these enzymes hydrolyze the cell wall polymer as a prelude to cell lysis. When chromosomally encoded the enzymes are therefore autolysins. Holins may also facilitate leakage of electrolytes and nutrients from the cell cytoplasm, thereby promoting cell death. Some may catalyze export of nucleases.	3.42995e-13
NC_014377.1\|WP_013275703.1\|888471_888744_-\|30S-ribosomal-protein-S20	gnl\|CDD\|376586	pfam01649, Ribosomal_S20p, Ribosomal protein S20. Bacterial ribosomal protein S20 interacts with 16S rRNA.	2.19239e-20
NC_014377.1\|WP_013275699.1\|883566_884055_+\|ADP-ribosylglycohydrolase-family-protein	gnl\|CDD\|377122	pfam03747, ADP_ribosyl_GH, ADP-ribosylglycohydrolase. This family includes enzymes that ADP-ribosylations, for example ADP-ribosylarginine hydrolase EC:3.2.2.19 cleaves ADP-ribose-L-arginine. The family also includes dinitrogenase reductase activating glycohydrolase. Most surprisingly the family also includes jellyfish crystallins, these proteins appear to have lost the presumed active site residues.	2.75271e-27
NC_014377.1\|WP_013275694.1\|879882_880638_+\|4-hydroxy-tetrahydrodipicolinate-reductase	gnl\|CDD\|234595	PRK00048, PRK00048, dihydrodipicolinate reductase; Provisional.	2.01404e-110
NC_014377.1\|WP_013275708.1\|891872_893675_+\|elongation-factor-4	gnl\|CDD\|235462	PRK05433, PRK05433, GTP-binding protein LepA; Provisional.	0
NC_014377.1\|WP_013275712.1\|896825_898412_+\|TCP-1/cpn60-chaperonin-family-protein	gnl\|CDD\|365887	pfam00118, Cpn60_TCP1, TCP-1/cpn60 chaperonin family. This family includes members from the HSP60 chaperone family and the TCP-1 (T-complex protein) family.	3.08678e-121
NC_014377.1\|WP_013275711.1\|895776_896808_+\|heat-inducible-transcription-repressor-HrcA	gnl\|CDD\|234621	PRK00082, hrcA, heat-inducible transcription repressor; Provisional.	3.76635e-136

>NC_014377.1|WP_013275701.1|886645_887656_+|DNA-polymerase-III-subunit-delta
MGELYLFYGQEKLLIREAIEKIKSKYVPEAYEVVDFQALDGEDVTYDEIVNVCRVMPMLAEKRVVVIYNAVFLEEGKKKAEKSGSGEARFIEFLENIPPYLCLIFSAEKVDKRKKIYKAIQQKGAAKEFSPLSFKDKVRWIQARSAKYGKPMDQSAAVYMAQFTADLYHADGEIKKAVAYVTDKDEIEKRDLDAIMSKSTEANIFELIDYLAEGKVPAAVKILNELIYSGEKVLVILFMVSRHFMNLLAVKANEGLAFQELRNALNMHPFALKKMVLQAKNFTTEQIINILALCQQLDIDLKKGRIEEKKGLEMLLTKIGEMRKGHPRNGRVEGDL
>NC_014377.1|WP_013275700.1|884239_886558_+|DNA-internalization-related-competence-protein-ComEC/Rec2
MYRPFLFVFLFFAAGIVAGEYIKILWPFALALIAGFGFYFFARDFRKTVFLGIIVFTAGALYHNFWSTNLEGTIANYAGNYRTVVGVVVSPPEVDETKVTYEVKTLYILQDGKYIKAPGKIRVSVARKDSAELLNYGDATEFSGFLRIPTNYENPGGFDYRAYLVQKGITATMFSREMKYLGRADVNPLVKSALDFRERIQNFYRRALSPKLASLLSGIVLGLKGDIPEDVLKAFSDGGVLHVLTASGLNVGIVYAAVEGVLKFLKLSPRACFFFGNIAVLFYSLMAGMSPPVLRAAVMLEVVMLGRLIGRKSDPLNSLGFAGFLLLLANSFNIFSASFQLSFAATLGIILFFKPLQRFFVSIPAFFRDSLAVLISAQLLLFPFLAYYFHKISLAGFLLNFIIVPLAGAALLGGFLTGIVSFLPFFAVPIVKITGVLVFLMDWVTTLASRLPFATFSVPSLGPLAVLAYFALIAAVFAPVEALGIKRRQKFAVIGLCFLIVAWSIFWVKPGFEVTFLDVGQGDCIFIKTKDGGTVLIDGGGMPAYYKGSFDIGEDVVLPYLYEQGVRKLDVVVFTHFDSDHAGGLLSIIEEMDVNAVVIGHPDYSEIYRKMVEVAAKKKIPVLTVSRGDIFRVGEAVFHVLNPKKHELFEDDNDNSVVLKMIYRGFRFLFTGDLGFEGEKDVMAECDVEADVLKIAHHGSNTSTSPEFLNKVNPDFAVISVGKNNSFGHPSPRVIELLEKSKIKVFRTDIHGAISFKIRGNNVRLYTQKKIN
>NC_014377.1|WP_013275699.1|883566_884055_+|ADP-ribosylglycohydrolase-family-protein
MKRTKEHFRGCLLGEATGDALGRPVEFLRPNEIKKEYGENGITDLITDINGKAGITDDTQITLFTAEDLLRAETRGREKGICHLHSVVYHAYLRWLQTQGYPQDSEKDFIYDGLLITVKELYARRGPGSTCLSALSSGRMGTIEQPVNNSKGCGGVMRVTPI
>NC_014377.1|WP_013275698.1|882690_883485_+|sugar-phosphate-isomerase/epimerase
MKQYGIFAWFGYLLPMETRLRLISEAGFDCVMLWWGDEFYDTDGEKTGHVDLARRYGLNVVNAHAPYEHADYLWDDGVNGDAYEALLSECIKTCAACEIPTLVIHPTGGPSPSFPVGNTGIQRLLRLLEEASRLGVTLALENLQRPDYLEYIFCNISSDYLGFCYDSGHAFLVSGGLSLLDRYGHLLRALHLHDNDGSEDQHLVPGEGNIDWEDLRLHLDAVGYSGPITLECCAPWHPDIKDASCESPESYLARALKAAKKLFR
>NC_014377.1|WP_013275697.1|881939_882653_+|DNA-alkylation-repair-protein
MSIIDQIKKELSEYIDNEKAAFLPRFFRAFEGGYGEGDRFIGVSVPNQRKVAKRYFNSIDIKDIERLLNEPVHEYRLTALFMLVYKFEKAKDEREREEIVNTYLRNIKAVNNWDLVDSSAPKILGPYLFNKDKSILYDMARTPDLWKQRIAIMSTFYFIKQGEFDDALNVARILLNHEHDLVHKAVGWMLREIGNRNFDVEYEFLKENYKVMPRTMLRYAIEKFEPELRQQFLEGLI
>NC_014377.1|WP_013275696.1|881101_881638_-|hypothetical-protein
MTNVAVAVSAQGYGHEGAFDYRAFKTGHIVIKPHNGKEFLKMLSEISKTSGPIHLMKVFSHSYPRGIIMTNWSGFYDEPGPNDTPNAAYISDLAELIDKREILFSANPQIMLFGCNLAGNFAEKLSAAVSGTVIAPRGDSYPKIRGNQETGVFIAVTQWEVYIRGRYAYSAGKRLRAW
>NC_014377.1|WP_013275695.1|880634_880997_-|zinc-ribbon-domain-containing-protein
MFFFGIFGIQDREKIIKEFDAVICPSCGRLSRAELIEVFTYFHFFFIPIFQWNRRYFVKYRCCPAVYAIEKDYAEELKSGASLDTSRLHKVFGHGNYCPDCGSYADPSFNFCPYCGRKID
>NC_014377.1|WP_013275694.1|879882_880638_+|4-hydroxy-tetrahydrodipicolinate-reductase
MIKIILNGARGKMGRTIAELVEREEDMQIAAGVDTVAESGKFPIYDSIIKIEEKADVIVDFSNPRALENLCSYASSRKIPMVVGTTGFEESHKKMLVEVSKDVPVFVSHNMSLGVYVTVMLAKQAARILGDFDVEIVERHHNQKIDAPSGTALMIADAIKEVRNEAHYVYCRADRREKRDRNEIGIHSIRAGNLVGEHRVIFGGEDETIEISHLVTSRKVLAAGALKAARFIITQAPGYYTMADLVKSLES
>NC_014377.1|WP_013275693.1|879560_879764_+|hypothetical-protein
MDDRQRQIEEIVDFVSHHKNSLASINICARVLGDKFVRVDDEVIRELKVKLPRADDEELESFYYMIK
>NC_014377.1|WP_013275692.1|878532_879516_+|biotin--[acetyl-CoA-carboxylase]-ligase
MISKDGSLNELLLLLLSKKGQYVSGEEISARFGVSRTAIWKQVNHLRQVGYEIDSLPRVGYCLKKSPDLLLPEEIIAKSKLTFLGRKIYYYPATASTNEEAKKLAGEGAHHGSLVIAEEQTGGKGRMGRVWLSPPRVGIWMSIILRPVIQPYEAPRITMTGAVAAAKAIRERTGVTCHIKWPNDILVEGKKVAGILTEMSADIDGINYVVMGIGINVNNDDFPGELKEIATSLKIAKGEAQDRLDILTGFLFRFEDYYNCLEAGEFKKILEEWRLLCCNLGRRVRVVGRNFTVEGIALDVDDDGALLVRSENGRVERILSGDVSLRA
>NC_014377.1|WP_013275703.1|888471_888744_-|30S-ribosomal-protein-S20
MPNTASAKKKMRQARKRTLRNRLVKSKIKAAIKKFNEALKLQDVENIKSALIGAVKALDKAASKGVIHKNAAARKKSRLYKKLKEHSIAI
>NC_014377.1|WP_013275704.1|888866_889193_+|phage-holin-family-protein
MVGMIIRFIVSALVLMLISFLLPGFQVAGFTGALIAAIVIAIMGFIVESILGEKISPQSRGIVGFITAAVVIYFAQFLVPAMKVTWWGALLASLVIGIVDAFVPTELR
>NC_014377.1|WP_041423860.1|889202_890174_+|GPR-endopeptidase
MINIRTDLAIEAREMTGKEEIPGVLIETEKSQEIAITRVRIINEDGEKALGKPKGYYVTLEVPRLREKDPKLTEEVSKNLAEELKFMINLPVESTVLVIGLGNWNVTPDSLGPKVVERLIVTKHLVELIPERFSPRNGIRPVCALAPGVLGITGIETGEIIKGVVERVKPELIIVIDALASRSLERISTTIQISDSGIHPGSGVGNRRMGITQKGMGVPVIAIGVPTVVDAATVASDTLEMLIAEFERQAKPGSEFYKMLQTLNREEKYQLIREVLSPFVGELVVTPKEIDSLIENISKTLSGGLNLALHPGISYEEVSTFLQ
>NC_014377.1|WP_148218447.1|890335_891385_+|stage-II-sporulation-protein-P
MAKSAPVFGNLKDPDRVKIVGDLDTRVFRAFLLWTIPAAGAYTSENVVFFNLGESLSKFQTESLGLFQPKGYLSFQIPLINLVKTEAVLTPGVELPEPGVVENEHTSSGNPPPAPPEDEGGDVEKVTPVAGKPLVLVYHTHTTESYMPSKAYNYKPRDQAFHTNDLNFTVARVGEVLTSELNRLGIPTIHNKTVHDVPTYMYSYSNSLKTVQEVLKKNPSIQIVLDVHRDAPAPDPQKAREVTTVKIDNKYYSRIMFVVGTDKVFPHPYWRENYKFALVLQKKLEELYPGITREIDLREQRFNQHVSKKALLVEIGSHGNTMEESIESAKAFAKTLAEVIKDLSKTQPE
>NC_014377.1|WP_013275707.1|891462_891831_+|hypothetical-protein
MYTKDPYIKDLFTLFLIFAVVLVLTLRFAEVRVYSTMGLDIAPITFDFKILPDRTYDFCVLDRRFSIRQFLKIGDFYADRRRVDIKFAGMNIIIPNMVRVYDPANLSYLRIYLDKKYPRMYN
>NC_014377.1|WP_013275708.1|891872_893675_+|elongation-factor-4
MTIPQERIRNFCIIAHIDHGKSTLADRLLEYTGTIPERKMEDQILDRMDLERERGITIKAQAVRMIYRADDGKDYLLNLIDTPGHVDFNYEVSRSLAACEGALLVVDASQGIEAQTLANTYLALEHDLEIVPVINKIDLPSANPDGVKREIEDIIGLPADDALLVSAKEGIGIKEVLEAVVKRIPPPKGSEDEPLRALIFDSLYDSYKGAIAFVRVMEGRIEPGQKIKMMSTGRTFEVTEVGIFSPDMVSTDSLRAGEVGYVVAGIKNVKDTRVGDTITNAENPAEKPLPGYKKAVPMVFSGVYPADGEDYEKLREALEKLQLNDAALFFEPETSAALGFGFRCGFLGLLHMEVIQERLEREYGINLITTAPSVVYRVKKTDGQEITVDNPTNFPDPSKIEYIEEPYVEASIMLPSDYVGAVMELCQEKRGIFKDMQYINEKRVIMRYDVPLAEIIYDFFDQLKSRTRGYASLDYEFTGYKKSELCKVDILINGEIVDALSFIVHKDKAYARARLLVEKLRDVIPRQLFEIPIQAAIGGRIIARETIKALRKNVLAKCYGGDVTRKKKLLEKQKEGKKRMRQLGKVEVPQEAFMSVLKMG
>NC_014377.1|WP_013275709.1|893680_894805_+|oxygen-independent-coproporphyrinogen-III-oxidase
MKELALYVHIPFCVKKCAYCDFNSYAETESIPLYVDSLKREISFYSGINRIVTSIYIGGGTPTVLSEGDLTSIIETIYGAFNISASLEFTVEANPETLSRRKLAVLRDAGVNRLSMGLQAFQDELLKIMGRIHTAKGFEEKFIIAREEGFDNINVDLIFGLPNQSVDDFRYSLGRLADLSPEHVSCYGLTVEEGTEFYRLQKEGRLPLPSEDEERKMYHTAREILKERGYSHYEISNFAKPGRECRHNLVYWTYGEYLGLGAGAHSFMDGVRFYNAYGIRDYAERVRSRGKGVEGEESLSLEEQQSEFMILGLRLIKGVRKAEFYKRFGKDPDSVYGSVLELLKKKELVTEDGEYIRLTERGLDLANEAFVEFL
>NC_014377.1|WP_013275710.1|894815_895691_+|RluA-family-pseudouridine-synthase
MKFVVDETSQGLTVGEFLKANGFSSRTIRRLKLGGKILINGVPAYTNTRISCNDVIEVDLTEKSGIVPSPVPINILYEDDHIIVLNKQPGVVVHPTAFHYNDTIANGVIYYLNQKGKKGGFHPVNRLDRDTTGVLIIALSQHMHNLIQTHGRMKKRYIAVVEGVVKENEGVIVEPIARREGSLIERCVSEKGQKAITRFKVVKRLKDLTVLDIEPVTGRTHQIRVHLSFKGHPVAGDTLYGGKNDRIKRQALHCAEMTFFYPVTGTYLSFKAPLPEDMVNLINSTPYLRFS
>NC_014377.1|WP_013275711.1|895776_896808_+|heat-inducible-transcription-repressor-HrcA
MLDDRKIKILRAIVVDYIATAEPVGSRTIARKYHMGISPATIRNEMADLEELGYIAQPYTSAGRIPSDKGYRFYVDFLMPVVNLSENEINAIHQIFKKRIKELEDLIEETSRVISNLTNYTTVILGPQLHDSRLKHVEILRLEKGKGLLIMVTNYGTIVHQIIELPQNLKDSDLTRISNLFNKYLVEKTVEEITPDYMNRIKNEMREYEEALKSFIQVLIERLQEVKESGKVFSSGSSRMLDFPEFKDVEKARNFLSLIEEEDFIIRVLKSTSKPNRITISIGNENPWKELQEFSIITTNFKVGGKSLGIFGVIGPTRMDYSKVVSILNKVEDYLNETLSTLI
>NC_014377.1|WP_013275712.1|896825_898412_+|TCP-1/cpn60-chaperonin-family-protein
MSFKNNNSQEIDEKFAAFLTNSNAIRAVSSAVEGTIGPKGLDIMLVDRFGEVTITNDGVTILKLMDINHPAAKMLINIAKAQQEEVGDGTTTATIMAGAMVSEGVNQIIRGVPVARVIEGIKYGVRRAQELLQSKSIPVKGMDDPALKNIAFIAGREHEDIAELVTQAAKLIGEEKLKERNFKLRDIVMAREGAENEVFLGIIVDKEKVNKQMPKEINDVRVMVIDDALEPEKIEEEALGTEAGFARYLALREEFKQNIQKLIDLKVNLVLVGKGICDEAQEMLTDAGVIALERVSTRDLEKVAEHTGARIIKRMGLKKPVEEIRNYIGEAERAYEDEKLEHIRIVGGKGKPMATILVGAATAEIVGERERIAKDAASSLQAAVKGGIVPGGGAVEVAVARELEKEREKVKGMASYGIDCVIAALKRPLAQIVYNAGFNPLEKLEEVIYTQAEKASDAIGVNCDTGELADMLQLGVIDPTLVKTHAVKAAGEIAQAILRIDTIIKKRDEGPAAKGASESVAGMGEMDF

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Crispr_ID: NC_014377_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014377_7

1643952-1644981

Orphan

Consensus_repeat	Method
GTTCTTAGTCTACCTATAAGGGATTGAAAC	PILER-CR
GTTCTTAGTCTACCTATAAGGGATTGAAAC	CRISPRCasFinder
GTTCTTAGTCTACCTATAAGGGATTGAAAC	CRT

15 spacers

The CRISPR arrays of NC_014377_7

>merge|NC_014377|7|1643952-1644981|PILER-CR,CRISPRCasFinder,CRT
GTTCTTAGTCTACCTATAAGGGATTGAAACAGAAATAATAATCGAATAACCTATCATTATTATGAGTTCTTAGTCTACCTATAAGGGATTGAAACCCGACCGTTTTTCCGCCTGATGGATTTTCACTTCTTCGTTCTTAGTCTACCTATAAGGGATTGAAACCATGGACAATAAGAAAGAGCTAATTGCAGAAATTATGTTCTTAGTCTACCTATAAGGGATTGAAACCCAGCTGCGAGAAGCGATTAAGGCGGAGAAGGACAGTTCTTAGTCTACCTATAAGGGATTGAAACAGGGTGTATTTGCTTCGCCTTCTATGGCGACTAACCTGGTTCTTAGTCTACCTATAAGGGATTGAAACATGAAATGGGATTCATTACGCCAGCAATCAGCTCAGGGTTCTTAGTCTACCTATAAGGGATTGAAACACATGGCATTAGCAACGTCTATGATTGAGAGCCCGAGTTCTTAGTCTACCTATAAGGGATTGAAACCTTGTATATCTCGCACCTGCCGCCTACCGCATAGGGGTTCTTAGTCTACCTATAAGGGATTGAAACTTATAAGGCAGGAGTATTCGCCGCTCACCAAAGGTTACGTTCTTAGTCTACCTATAAGGGATTGAAACACACAAACCTCCCCCGCTTCGAGCAGGGTGCATTCAGCGTTCTTAGTCTACCTATAAGGGATTGAAACTACAGCCGCCACATCGCCTCTTTTTGCCCCGCTATACGTTCTTAGTCTACCTATAAGGGATTGAAACCCAAAAGATAGCCCTACAATCTGGTCTGTAAACAAAGTTCTTAGTCTACCTATAAGGGATTGAAACAAGCGTTCTTTAAGACTACTAGCTTGAATATCTAACCGTTCTTAGTCTACCTATAAGGGATTGAAACAACTCTTGCTCTTTCATAGGCATCTACTCCTTGAAGAGTTCTTAGTCTACCTATAAGGGATTGAAACCTCACAACGGATTGAAAAAAGTTTGCCGCTACCCAAGGTTCTTAGTCTACCTATCCTGAAAATAATG

>NC_014377|7|5|1643952-1644914|PILER-CR
GTTCTTAGTCTACCTATAAGGGATTGAAAC	AGAAATAATAATCGAATAACCTATCATTATTATGA
GTTCTTAGTCTACCTATAAGGGATTGAAAC	CCGACCGTTTTTCCGCCTGATGGATTTTCACTTCTTC
GTTCTTAGTCTACCTATAAGGGATTGAAAC	CATGGACAATAAGAAAGAGCTAATTGCAGAAATTAT
GTTCTTAGTCTACCTATAAGGGATTGAAAC	CCAGCTGCGAGAAGCGATTAAGGCGGAGAAGGACA
GTTCTTAGTCTACCTATAAGGGATTGAAAC	AGGGTGTATTTGCTTCGCCTTCTATGGCGACTAACCTG
GTTCTTAGTCTACCTATAAGGGATTGAAAC	ATGAAATGGGATTCATTACGCCAGCAATCAGCTCAGG
GTTCTTAGTCTACCTATAAGGGATTGAAAC	ACATGGCATTAGCAACGTCTATGATTGAGAGCCCGA
GTTCTTAGTCTACCTATAAGGGATTGAAAC	CTTGTATATCTCGCACCTGCCGCCTACCGCATAGGG
GTTCTTAGTCTACCTATAAGGGATTGAAAC	TTATAAGGCAGGAGTATTCGCCGCTCACCAAAGGTTAC
GTTCTTAGTCTACCTATAAGGGATTGAAAC	ACACAAACCTCCCCCGCTTCGAGCAGGGTGCATTCAGC
GTTCTTAGTCTACCTATAAGGGATTGAAAC	TACAGCCGCCACATCGCCTCTTTTTGCCCCGCTATAC
GTTCTTAGTCTACCTATAAGGGATTGAAAC	CCAAAAGATAGCCCTACAATCTGGTCTGTAAACAAA
GTTCTTAGTCTACCTATAAGGGATTGAAAC	AAGCGTTCTTTAAGACTACTAGCTTGAATATCTAACC
GTTCTTAGTCTACCTATAAGGGATTGAAAC	AACTCTTGCTCTTTCATAGGCATCTACTCCTTGAAGA
GTTCTTAGTCTACCTATAAGGGATTGAAAC

>NC_014377|7|7|1643952-1644981|CRISPRCasFinder
GTTCTTAGTCTACCTATAAGGGATTGAAAC	AGAAATAATAATCGAATAACCTATCATTATTATGA
GTTCTTAGTCTACCTATAAGGGATTGAAAC	CCGACCGTTTTTCCGCCTGATGGATTTTCACTTCTTC
GTTCTTAGTCTACCTATAAGGGATTGAAAC	CATGGACAATAAGAAAGAGCTAATTGCAGAAATTAT
GTTCTTAGTCTACCTATAAGGGATTGAAAC	CCAGCTGCGAGAAGCGATTAAGGCGGAGAAGGACA
GTTCTTAGTCTACCTATAAGGGATTGAAAC	AGGGTGTATTTGCTTCGCCTTCTATGGCGACTAACCTG
GTTCTTAGTCTACCTATAAGGGATTGAAAC	ATGAAATGGGATTCATTACGCCAGCAATCAGCTCAGG
GTTCTTAGTCTACCTATAAGGGATTGAAAC	ACATGGCATTAGCAACGTCTATGATTGAGAGCCCGA
GTTCTTAGTCTACCTATAAGGGATTGAAAC	CTTGTATATCTCGCACCTGCCGCCTACCGCATAGGG
GTTCTTAGTCTACCTATAAGGGATTGAAAC	TTATAAGGCAGGAGTATTCGCCGCTCACCAAAGGTTAC
GTTCTTAGTCTACCTATAAGGGATTGAAAC	ACACAAACCTCCCCCGCTTCGAGCAGGGTGCATTCAGC
GTTCTTAGTCTACCTATAAGGGATTGAAAC	TACAGCCGCCACATCGCCTCTTTTTGCCCCGCTATAC
GTTCTTAGTCTACCTATAAGGGATTGAAAC	CCAAAAGATAGCCCTACAATCTGGTCTGTAAACAAA
GTTCTTAGTCTACCTATAAGGGATTGAAAC	AAGCGTTCTTTAAGACTACTAGCTTGAATATCTAACC
GTTCTTAGTCTACCTATAAGGGATTGAAAC	AACTCTTGCTCTTTCATAGGCATCTACTCCTTGAAGA
GTTCTTAGTCTACCTATAAGGGATTGAAAC	CTCACAACGGATTGAAAAAAGTTTGCCGCTACCCAAG
GTTCTTAGTCTACCTATCCTGAAAATAATG

>NC_014377|7|5|1643952-1644981|CRT
GTTCTTAGTCTACCTATAAGGGATTGAAAC	AGAAATAATAATCGAATAACCTATCATTATTATGA
GTTCTTAGTCTACCTATAAGGGATTGAAAC	CCGACCGTTTTTCCGCCTGATGGATTTTCACTTCTTC
GTTCTTAGTCTACCTATAAGGGATTGAAAC	CATGGACAATAAGAAAGAGCTAATTGCAGAAATTAT
GTTCTTAGTCTACCTATAAGGGATTGAAAC	CCAGCTGCGAGAAGCGATTAAGGCGGAGAAGGACA
GTTCTTAGTCTACCTATAAGGGATTGAAAC	AGGGTGTATTTGCTTCGCCTTCTATGGCGACTAACCTG
GTTCTTAGTCTACCTATAAGGGATTGAAAC	ATGAAATGGGATTCATTACGCCAGCAATCAGCTCAGG
GTTCTTAGTCTACCTATAAGGGATTGAAAC	ACATGGCATTAGCAACGTCTATGATTGAGAGCCCGA
GTTCTTAGTCTACCTATAAGGGATTGAAAC	CTTGTATATCTCGCACCTGCCGCCTACCGCATAGGG
GTTCTTAGTCTACCTATAAGGGATTGAAAC	TTATAAGGCAGGAGTATTCGCCGCTCACCAAAGGTTAC
GTTCTTAGTCTACCTATAAGGGATTGAAAC	ACACAAACCTCCCCCGCTTCGAGCAGGGTGCATTCAGC
GTTCTTAGTCTACCTATAAGGGATTGAAAC	TACAGCCGCCACATCGCCTCTTTTTGCCCCGCTATAC
GTTCTTAGTCTACCTATAAGGGATTGAAAC	CCAAAAGATAGCCCTACAATCTGGTCTGTAAACAAA
GTTCTTAGTCTACCTATAAGGGATTGAAAC	AAGCGTTCTTTAAGACTACTAGCTTGAATATCTAACC
GTTCTTAGTCTACCTATAAGGGATTGAAAC	AACTCTTGCTCTTTCATAGGCATCTACTCCTTGAAGA
GTTCTTAGTCTACCTATAAGGGATTGAAAC	CTCACAACGGATTGAAAAAAGTTTGCCGCTACCCAAG
GTTCTTAGTCTACCTATCCTGAAAATAATG

Protein	Signature genes	Signature genes Name	Protein_function
NC_014377.1\|WP_013276416.1\|1635843_1636680_-\|purine-or-other-phosphorylase-family-1	unknown	unknown	gnl\|CDD\|350159
NC_014377.1\|WP_013276428.1\|1651622_1652693_-\|copper-amine-oxidase-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|377924
NC_014377.1\|WP_041423913.1\|1642565_1642880_+\|DUF2935-domain-containing-protein	unknown	unknown	gnl\|CDD\|378573
NC_014377.1\|WP_013276423.1\|1642047_1642284_+\|DUF2935-domain-containing-protein	unknown	unknown	gnl\|CDD\|378573
NC_014377.1\|WP_148218408.1\|1653133_1653835_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224117
NC_014377.1\|WP_187286567.1\|1652731_1652902_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226376
NC_014377.1\|WP_013276432.1\|1660788_1662516_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_014377.1\|WP_013276427.1\|1647395_1651043_+\|5'-nucleotidase-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|236505
NC_014377.1\|WP_013276421.1\|1639622_1640438_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NC_014377.1\|WP_083768498.1\|1638149_1638989_-\|L,D-transpeptidase-family-protein	unknown	unknown	gnl\|CDD\|341130
NC_014377.1\|WP_013276426.1\|1646748_1647051_+\|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|367130
NC_014377.1\|WP_148218406.1\|1640603_1641890_-\|hydroxylamine-reductase	unknown	unknown	gnl\|CDD\|183427
NC_014377.1\|WP_013276417.1\|1636827_1637460_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274009
NC_014377.1\|WP_013276431.1\|1658923_1660792_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_014377.1\|WP_013276429.1\|1653935_1656785_-\|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl\|CDD\|234734
NC_014377.1\|WP_187286566.1\|1642261_1642432_+\|DUF2935-domain-containing-protein	unknown	unknown	gnl\|CDD\|378573
NC_014377.1\|WP_013276418.1\|1637864_1638098_+\|hypothetical-protein	unknown	unknown	unknown
NC_014377.1\|WP_013276430.1\|1656801_1658817_-\|excinuclease-ABC-subunit-UvrB	unknown	unknown	gnl\|CDD\|235395
NC_014377.1\|WP_013276425.1\|1645078_1646299_-\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376564
NC_014377.1\|WP_013276420.1\|1638908_1639577_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133022

Protein	Function_ID	Function_description	E-value
NC_014377.1\|WP_013276416.1\|1635843_1636680_-\|purine-or-other-phosphorylase-family-1	gnl\|CDD\|350159	cd09008, MTAN, 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidases. This subfamily includes both bacterial and plant 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidases (MTANs): bacterial MTANs show comparable efficiency in hydrolyzing MTA and SAH, while plant enzymes are highly specific for MTA and are unable to metabolize SAH or show significantly reduced activity towards SAH. MTAN is involved in methionine and S-adenosyl-methionine recycling, polyamine biosynthesis, and bacterial quorum sensing. This subfamily belongs to the nucleoside phosphorylase-I (NP-I) family, whose members accept a range of purine nucleosides as well as the pyrimidine nucleoside uridine. The NP-1 family includes phosphorolytic nucleosidases, such as purine nucleoside phosphorylase (PNPs, EC. 2.4.2.1), uridine phosphorylase (UP, EC 2.4.2.3), and 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP, EC 2.4.2.28), and hydrolytic nucleosidases, such as AMP nucleosidase (AMN, EC 3.2.2.4), and 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase (MTAN, EC 3.2.2.16). The NP-I family is distinct from nucleoside phosphorylase-II, which belongs to a different structural family.	1.32739e-15
NC_014377.1\|WP_013276426.1\|1646748_1647051_+\|carboxymuconolactone-decarboxylase-family-protein	gnl\|CDD\|367130	pfam02627, CMD, Carboxymuconolactone decarboxylase family. Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.	1.02367e-10
NC_014377.1\|WP_013276423.1\|1642047_1642284_+\|DUF2935-domain-containing-protein	gnl\|CDD\|378573	pfam11155, DUF2935, Domain of unknown function (DUF2935). This family of proteins with unknown function appears to be restricted to Firmicutes. The structure of this protein has been solved and each domain is composed of four alpha helices. A metal cluster composed of iron and magnesium lies between the two domains.	3.12479e-07
NC_014377.1\|WP_148218408.1\|1653133_1653835_+\|hypothetical-protein	gnl\|CDD\|224117	COG1196, Smc, Chromosome segregation ATPases [Cell division and chromosome partitioning].	1.95509e-08
NC_014377.1\|WP_041423913.1\|1642565_1642880_+\|DUF2935-domain-containing-protein	gnl\|CDD\|378573	pfam11155, DUF2935, Domain of unknown function (DUF2935). This family of proteins with unknown function appears to be restricted to Firmicutes. The structure of this protein has been solved and each domain is composed of four alpha helices. A metal cluster composed of iron and magnesium lies between the two domains.	1.3347e-07
NC_014377.1\|WP_187286567.1\|1652731_1652902_-\|hypothetical-protein	gnl\|CDD\|226376	COG3858, COG3858, Predicted glycosyl hydrolase [General function prediction only].	0.00183139
NC_014377.1\|WP_013276432.1\|1660788_1662516_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	3.35456e-163
NC_014377.1\|WP_013276427.1\|1647395_1651043_+\|5'-nucleotidase-C-terminal-domain-containing-protein	gnl\|CDD\|236505	PRK09419, PRK09419, multifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase/5'-nucleotidase.	3.56498e-144
NC_014377.1\|WP_013276421.1\|1639622_1640438_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	9.44706e-35
NC_014377.1\|WP_083768498.1\|1638149_1638989_-\|L,D-transpeptidase-family-protein	gnl\|CDD\|341130	cd16913, YkuD_like, L,D-transpeptidases/carboxypeptidases similar to Bacillus YkuD. Members of the YkuD-like family of proteins are found in a range of bacteria. The best studied member Bacillus YkuD has been shown to act as an L,D-transpeptidase that gives rise to an alternative pathway for peptidoglycan cross-linking. Another member Helicobacter pylori Csd6 functions as an L,D-carboxypeptidase and regulates helical cell shape and motility. The conserved region contains a conserved histidine and cysteine, with the cysteine thought to be an active site residue.	1.61808e-39
NC_014377.1\|WP_013276431.1\|1658923_1660792_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	0
NC_014377.1\|WP_148218406.1\|1640603_1641890_-\|hydroxylamine-reductase	gnl\|CDD\|183427	PRK12310, PRK12310, hydroxylamine reductase; Provisional.	0
NC_014377.1\|WP_013276417.1\|1636827_1637460_-\|hypothetical-protein	gnl\|CDD\|274009	TIGR02169, chromosome_segregation_protein_related_ptotein, chromosome segregation protein SMC, primarily archaeal type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	2.52121e-07
NC_014377.1\|WP_013276429.1\|1653935_1656785_-\|excinuclease-ABC-subunit-UvrA	gnl\|CDD\|234734	PRK00349, uvrA, excinuclease ABC subunit UvrA.	0
NC_014377.1\|WP_187286566.1\|1642261_1642432_+\|DUF2935-domain-containing-protein	gnl\|CDD\|378573	pfam11155, DUF2935, Domain of unknown function (DUF2935). This family of proteins with unknown function appears to be restricted to Firmicutes. The structure of this protein has been solved and each domain is composed of four alpha helices. A metal cluster composed of iron and magnesium lies between the two domains.	4.3456e-08
NC_014377.1\|WP_013276428.1\|1651622_1652693_-\|copper-amine-oxidase-N-terminal-domain-containing-protein	gnl\|CDD\|377924	pfam07833, Cu_amine_oxidN1, Copper amine oxidase N-terminal domain. Copper amine oxidases catalyze the oxidative deamination of primary amines to the corresponding aldehydes, while reducing molecular oxygen to hydrogen peroxide. These enzymes are dimers of identical subunits, each comprising four domains. The N-terminal domain, which is absent in some amine oxidases, consists of a five-stranded antiparallel beta sheet twisted around an alpha helix. The D1 domains from the two subunits comprise the 'stalk' of the mushroom-shaped dimer, and interact with each other but do not pack tightly against each other.	2.61386e-36
NC_014377.1\|WP_013276430.1\|1656801_1658817_-\|excinuclease-ABC-subunit-UvrB	gnl\|CDD\|235395	PRK05298, PRK05298, excinuclease ABC subunit UvrB.	0
NC_014377.1\|WP_013276425.1\|1645078_1646299_-\|IS110-family-transposase	gnl\|CDD\|376564	pfam01548, DEDD_Tnp_IS110, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family includes an amino-terminal region of the pilin gene inverting protein (PIVML) and of members of the IS111A/IS1328/IS1533 family of transposases. The C-terminus is represented by family pfam02371.	1.16737e-41
NC_014377.1\|WP_013276420.1\|1638908_1639577_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|133022	cd04179, DPM_DPG-synthase_like, DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily. DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.	3.17175e-42

>NC_014377.1|WP_041423913.1|1642565_1642880_+|DUF2935-domain-containing-protein
MALYFRPGQEAYMKEMLQWERQIRRLYNEIGKAFRASRSPEPFISISINIMKHWGGFLQRLLADLTRCTIPGRQMNVWPRIVDHMIRENNYFIEVLEILQKMRC
>NC_014377.1|WP_187286566.1|1642261_1642432_+|DUF2935-domain-containing-protein
MLDFIDFKGRVAAGIRACRILSILPAELVDHIRREALFFSEYWPGSKVGRDHLGGN
>NC_014377.1|WP_013276423.1|1642047_1642284_+|DUF2935-domain-containing-protein
MDIQHDLFLQREINFGVEIMKDHARFMRNAFDPTEEFLFNESDEFYRRFNFLTDELEPERDGAGMLLPAEPGAGLHRL
>NC_014377.1|WP_148218406.1|1640603_1641890_-|hydroxylamine-reductase
MFCYQCEQTPKGGCTRIGVCGKNEDISSLQDIIILGLKGISAYAVHARELGFTDPEVDATVQEALYMTLTNVNFNLKEHIDMAMKVGKATIKVMELLDKAHTSKFGIPEPVTVSQDKIEGHCILVTGHNLHALGELLKQSEGKGVNVYTHSEMLPAHGYPELRKYKHLKGNIGKSWTDQRKLFEEFPGAILGTTNCIMPIKGSYSDRFFSYGVAGLEGVQKIENDDFTPVIEKALSLPPANADSDKKVITGFHHETVLKIAPEVIEAVKAGKIRRFFVIAGCDTPGSGNDYYRQLALSLPKDCVILTTSCGKFRFNDVDYGTVPGTNIPRYIDLGQCNNSISAVKIAAALAEAFNCSVNDLPLTIVLSWFEQKAVAILLGLLSLGVKNIYIGPKAPEFFTPGVIKVLQDNFNLKLISDVNKDLPDMLG
>NC_014377.1|WP_013276421.1|1639622_1640438_-|alpha/beta-hydrolase
MGYYISVEQNVNIFVEDLDPGHGKPILFIHGWPLNHKQFEYQFNQLPKMGYRCIGIDLRGFGKSDRPWKGYSYNRLADDIRIVIDTLQLEDITLAGHSMGGAIAIRYMARHAGHKVSKLVLIGAAAFTRRPFGLTKEEVKRWERTWNDLIEATYIDRPKMLDGVGDVFFARYVTESFKDWFHGLGIEASGHATAMCAVSLRDEDLGQDLSKIYVPTGIFHGIHDKVCPFKFAELMHAQIKGSELIPFMYSGHGLFYEEWEKFNRELIRFIG
>NC_014377.1|WP_013276420.1|1638908_1639577_+|glycosyltransferase-family-2-protein
MEVSVVIPAFNEEDNIASVVKKAMELHNLREVIVVDDGSSDRTARTAASAGAIVIKHNANLGKGKALMTGFEATKGEIVVFLDADLRFDTGDLEKLIEAVVRGDADMTIARFPRPLKKGGFGFVKALAGWGVYLLTGHRISAPLSGQRAIKREVLESVKEIPGGFGAEVGFLIDALRKGFRVVEVDVNMRHRETGRSLRDFAHRGRQFVDILVTLLRKVYAV
>NC_014377.1|WP_083768498.1|1638149_1638989_-|L,D-transpeptidase-family-protein
MKFHSLFYDRCNIIFFIKGGNHYAYFHPDPSECKLNLKVKLKPKRWEVKFLRKSIRVIAFMIIFLMSFYSPSPAYQPTSPKPPDKPQGDVSIVIYALERKLVVMVDGKPFKTFPVAVGTFDTPTPIGLFRITEKSKWGEGFGTRWMRLSVPWGTYGIHGTNKPHSIGSFASHGCIRMHNRHVEQLYDWVKVGTKVYIVGGVDGPFTFGFRTLVEGSRGSDVMEVQKRLANHGFYNGSFDGIYGSGTREAVKAFQKAKGLKATGIVDEATYKALGICRFE
>NC_014377.1|WP_013276418.1|1637864_1638098_+|hypothetical-protein
MTPPIETGEDIERTISVIKSAIMKAGALSEDLVESIKAELREAKPDVVCDFLNKLARECPAAVEHFTNSERAENPIL
>NC_014377.1|WP_013276417.1|1636827_1637460_-|hypothetical-protein
MTKTELLKKLIDKFEQLESVEGLDSIDQFVDGLVGELESDEGAKVSTFDLAIIALLLNKKFGLKEIKKEIKDIEKKLDDKDFGLKEIKKEIKDIEKKLDDDKFGLKEIKKEIKDIEDKLDSKDFGLEEIKKEVKEIEKKLDDDKFGLKEIKKEIKEIEYKLDNKDFGLKEIKKEIKDIEDKLDNKDFGLKEIKKEIKDIEEKLDCKNYTL
>NC_014377.1|WP_013276416.1|1635843_1636680_-|purine-or-other-phosphorylase-family-1
MFYIVTAFHTEAKPIIEHFGLKKIPRPCRFQVFAGDNMVLVESGMGIVASAAATSFLLTEFKAGERDVILNVGICGAKEKSLKKGDAVLCHKVINHDTKRAFYPDVIVKHAMKEGVLETFSFPVDKDEYPESHIEGDLVDMEGAGFFEAASFFLPPHKIHCVKVVYDYLDGERVDPVRVLEYIRGNIPLIESLMTCYNALDEQYPMVFDEGEPEIIREISRNLKLSVTMTHQLKDMVRAYVARHKRGPEELKGFLNIKVCSKNEGKVYFERIREMLSH
>NC_014377.1|WP_013276425.1|1645078_1646299_-|IS110-family-transposase
MDVVYSHVCGLDVHKKSVVACVITPDGKEIRSFSTMTDDLFALKEFIKNKGCTVVAMKSTGSFWKPIYNLLELENLKILLVNAKHIKNVPGRKTDVKDAEWIASLLRHGLLKGSFVPDREQRELRELVRYRHGLVEERSRELNRIQKVLEGANIKLSSVVSDINGMSSRAILEALISGVDDPEILAELSHGKLKNKKEDLKRALKGFINYHQRKMLEIKLKHIDYLDEEIERLDEEIKNRMLPFEEDLALLDTIPGVGRRTAEQIIAEIGTNMDQFPSAAHLCSWAGLCPGQNESAGKRKSARTRKGNKKLRSALVEAARAASRAKDTYLSSQYHRIAARRGSNRAAVAVANSILTIVYHILKRKQPYIELGPNFYEEKRRNMVIRQSLKKLESLGLKVTVETIVS
>NC_014377.1|WP_013276426.1|1646748_1647051_+|carboxymuconolactone-decarboxylase-family-protein
MPLPPFLASVEKNDPDFAKAIEGVFSSAMGPGALDQKTKLLIALALDAAHGAYQGVMNISKQLKNMGVKDEEIAEAIRIAYFAFGNSILASYSAAFSENK
>NC_014377.1|WP_013276427.1|1647395_1651043_+|5'-nucleotidase-C-terminal-domain-containing-protein
MGRPVSKLLAFLISFCLLASSMAFPLQAAAQTQEVKITILATSDLHGNIYPFDYFTLKDSNVGLAKISTLVKKVRGENPNTLLLDNGDTIQGTPLVYYFTKVEPDKPHPMIKVMNAMGYDAMVVGNHEIQDFGYDWLEKVKNQANFPILAANLYLPDGQPAYTPYVIKEIAGVKVGILGLTSKNLPNWTTKQKLGPLTVKDAVEEAKKWVPQLRDKVDLLVVSAHMGFEVDLKTGASNGTAYENQAYALTKEVPGIDVLITGHSHMDIPPQLVNGVLVVQPYRWGSKLARLDITLLKTDNGWQIKEKMGEDLAVDGVEADPEVMALAGDYHEAALAYVNSTIGEAAGDFHGTYSRLKDTAIMDLIHKVQLKVTGADLSMAAMLPADPPTLKKGPLTVRDIYSLYIYENTLLKLEVTGKLIKEALEWSATYYNTYDFGAGSSPLINPDKRHYNFDTIQGVEYIMDISRPPGQRIRNLTYKGKPVRDDQKFTIAVNSYRASGGGGYTMFKDAPVLFQTTEEIRNLIIEYIKEQKVIYPETDNNWRLLPDHITHWAKEDVDRLVRNKALTGFSDGTFALEQPITRAQYAVLVARAYGIEPVKAPASRFKDVPGGHWASGYIETLAQKGLVNGKQAGLFAPEAPLTREEAAVILARIMGAAGTAKKENALAGFTDAWSVSPWAREALAFALEKGLLRGYPGGTLNPKKEVTRGEVAALVARGRYPVVTILHLNDLHGYITERLDNNNKPFGGMARVATVVAETRKQNPWTLMVDSGDHIQGAPIANFFYGSNVIEAYNAIQLDLATFGNHEFDWGRETIKNRMNEAKYDYICANLNDSKSGQLFTGKGYVVKEVGPVAIGFTGLITPELPTLVNPKGIEGLKVLDPVAAAGETVAALKKNGSVYNIVLSHMGVEEDKKLAQKVEGIDLIIGGHSHTRLDQPVEVSGVKIVQTGQHGENLGRIDLEFAVDRNGAKLLNMKYRLIPIDESIKPDEKIKNLIKPYEEELNAKMDEVIGEALVDLVGEREKVRTGETNLGNFIADWMRTALGADIAITNAGGIRASIAKGPIRVRDIYSVLPFDNLLVLVELTGSQVIEALENAYSKYPLADGRFAQISGIKVTIDPSKEPGQRVTEVLVNGVPIDPQAKYKVATNDFLYNGGDGYEVFKNGKFLGWSTGEWMRDELIRYLRQYPQVNPAVEGRIIIPKQQSRMLPAINNRAA
>NC_014377.1|WP_013276428.1|1651622_1652693_-|copper-amine-oxidase-N-terminal-domain-containing-protein
MARLSKIFREAEQNSQFVRLYFLERKFLKEVLPVRKKWLWNLLIVVLLITSLPGSVMADQPIAVTLNSEQLHFDVLPILENSRVLVPLRAIFETLGATVDWNGTTGTVTAAKGNSIVTLTVGENMAYKNGARVELDVPTKIVNGRTLVPVRFVSEALGERVYWIPKTSTVLIFSQDILTYNLNKLAQMVEQTKNQNLEEARKLVINNNGLWRYLLLTKEDWIAKSNILQYETTDLHNIWFPEGEALRFLARFVNRPYSLDQSPYEQTGSPIIDVVTFIDLSGEKPSLVWLAYLGKANEKIITFKDDTIDLTLKSYMEKWHGADWGYRVVNGTKPDLLGVKLQGYRPGPGYWFPINN
>NC_014377.1|WP_187286567.1|1652731_1652902_-|hypothetical-protein
MYQAMARVSIPPEKLVLGIFTPTETPESMLTKVGIIKRYGLIDIAIWRLGLVTGEM
>NC_014377.1|WP_148218408.1|1653133_1653835_+|hypothetical-protein
MTKTELLKKLIDKFEQLESVEDLDNIDQFLDGFLGELETAGDAQISSFDLAVIALLLNRKFGLKEIKKEIKDIEKKLDDKDFGLKEIKKEIKHIEKKLDDDKFGLKEIKKEIKDIEDKLDSKDFGLEEIKKEVKEIEKKLDDDKFGLKEIKKEIKDIEDKLDNKDFGLKEIKKEIKDIEDKLDSKDFGLKEIKKEIKDIEDKLDNKDFGLKEIKKEIKDIEEKLDRKDFIFEK
>NC_014377.1|WP_013276429.1|1653935_1656785_-|excinuclease-ABC-subunit-UvrA
MSKDKIIVKGARQHNLKNIDVEIPRDKLVVITGISGSGKSTLAFDTIYAEGQRRYVESLSAYARQFLGQMDKPDVDYIEGLSPAISIDQKTTSKNPRSTVGTVTEIYDYLRLLFARIGKPHCPRCGREISQQTVDQMVDAVMELPEGTRIQVLSPVIRGRKGEHLKLIEQIKKDGFVRIRVDGEIRETAEEIKLDKNKKHNIDIIVDRIIVKPGVESRLADSIETALARAGGLVVIDVIGDKEILFSQNFACPDCGISLEELSPRMFSFNSPYGACPACSGLGVNMEIDPDLVIPDRSKSVAEGAIVPWNSSPDGYYFQMLQAVLEHYGYDVETPIEKMDERMIEILLYGSDEVIDFYYESRYGSSRHFRGYFEGVINNLKRRYEETDSEWSREEIEEFMSTRPCPACKGARLKPESLAVKVGGLSIAQVTAFSIKDAMDFFNNLQLTEKERLIAHQVLKEIKSRLQFLIDVGLEYLTLDRPSGTLSGGESQRIRLATQIGSRLVGVLYILDEPSIGLHQRDNERLIKTLKELRDLGNTVLVVEHDEDTMRAADYIIDIGPGAGENGGRVVAAGPVEVIEKCEESLTGQYLSGRLTIPVPPVRRKPDGRWIVLKGCREHNLKNIDVKFPVGLFTCVTGVSGSGKSTLVNEILYKALREKLYKVKTRPGDFDDIEGVEYVDKVINIDQSPIGRTPRSNPATYTGVFNDIREVFSLTPEARMRGYKPGRFSFNVKGGRCEACKGDGIIKIEMHFLADVYVPCEVCKGKRYNRETLEVKYKGKSIADVLDMTVDEALEFFQNIPKIKRKLETLRDVGLGYIKLGQSSTTLSGGEAQRVKLATELSRKNNGGTVYILDEPTTGLHPADIKKLLDVLHRLVESGSTVIVIEHNLDVIKTADYIIDLGPEGGDGGGEVIALGTPEEVAANERSYTGYFLKKVLGMHEMKKVSSAG
>NC_014377.1|WP_013276430.1|1656801_1658817_-|excinuclease-ABC-subunit-UvrB
MGEFRVVSEFTPKGDQPKAIAALSEGIRKGYKFQTLLGATGTGKTFTIANLIEKVQKPTLVIAHNKTLAGQLCSELKEFFPNNAVEYFVSYYDYYQPEAYIPQTDTYIEKDASINDEIDKLRHSATAALFERRDVVIVASVSCIYSLGSPVDYENQVISLRPGMVKDRDEIIRRLVEIQYTRNEFEFSRNTFRVHGDILEIYPASFTERAIRVEFFGDVIDRITEIDTLTGEVMGERTHVSIFPASHYVTPRDKLEAAIKSIKEELEERLAELRAKGKLLEAARLEQRTNYDIEMLRETGYCKGIENYSRHLTGRKPGEPPFTLLDYFPRDYLIIIDESHVTIPQLRAMWAGDRSRKEALVEHGFRLPSAFDNRPLTFEEFEERINQVIFLSATPGPYELEKSSQVVEQIIRPTGLVDPEVEVRPTKGQIDDLIGEIRKRAEKDQRVLVTTLTKKMAEDLCDYLRESGIKVKYLHSEINTLERLQILRDLRLGKFDCLVGVNLLREGLDLPEVSLVAILDADKEGFLRSETSLIQTIGRAARNAEGRVIMYADTITESMARAISETNRRRMIQMEYNRKHGIVPTTVKKGIREMIEATKAAEERADYLPEKDLARMSKKELKAYLDKLEKEMKQAARNLEFERAAQLRDIIFEIKAQAFSVVRDRKTVSKS
>NC_014377.1|WP_013276431.1|1658923_1660792_-|ABC-transporter-ATP-binding-protein
MSAGPGGPVFTGRRHGGRGFVGGLPMVRPAEKPKDFKGTLGRLIKYLKPYAFEFFIVLILVLLSTVFNILGPKIMGEATTKLFEGLIAKRMHVPGAKIDFEYIAKILFILAGLYASSALFTYIQQYIMVSISQKTVLKMRNDVVEKLSKLPLKYFDSRTHGEILSRITNDIDNVSSTLQQSIIQLISAVVTIIGIVVMMLTINPVLTLITFVTLPLSIIATMSIAAKSQKLFAKQQRVLGELNGHVEETYGGHNIVKAFNREKDVLKIFNDINEELYNAAWKAQFMSGVIMPVMNFINNIGYVIVCVVGGIFVIKKILEIGDVQAFIQYSRQFNHPITQTANIVNIIQSTIASAERVFEILDEEEEVPDKAKFFLNDIKGKIKFENVKFSYKQNMPLIDNLNIEVSPGQTVAIVGPTGAGKTTLVNLLMRFYEIQDGRITIDGVDIRDISRANLRKIFGMVLQDTWLFSGTIKENIAYGKEGATDEEIIKAAKAAHAHHFIKTLPGGYDTLLNEEASNISQGQKQLITIARAFLADPEILILDEATSNVDTLTEIYIQKAMKNLMKGRTSFVIAHRLSTIKDADIILVVNNGKIIEKGTHKELLDRGGFYAELYKSQFLGAI
>NC_014377.1|WP_013276432.1|1660788_1662516_-|ABC-transporter-ATP-binding-protein
MIKLLKFLKPYRNYVIVSLILIFFQSISELYLPNLMSDIVDIGIVKGDIRYILQKGEIMLLVAAGGTVSAIVASYLSSQAAMGFGKILRNKIFSQVENFSLQEFDKFGTASLITRTTNDVNQIQMVIMITLRMVARAPLICIGGIILAVSKDARLSLILLITVPILAFLVFVLYKKAMPLFDAIQKKIDRVNLILRENLTGIRVIRAFNKIEYEKKRFNEANIDLTNMSIKVNRIMAWLMPAMMLLLNFTIIAVIWFGGIRIDKGTMQVGDLMAFIQYIIQIMFSLIMVSVVFVMLPRASASALRINEVLEIVPKIKEPEKPEEIKNIRGVIEFKDVTFSYPGADEPALKNISFKAEPGKLTAIIGGTGSGKSTVLNLIMRFYDADSGSILIDGVDIKLLPQTKLRDMIGYVPQKAVLFSGTIADNIRFGKNDAADEQIRKAACIAQATEFIFQMKDEFNSEISQGGKNLSGGQKQRLAIARAVVKRPKIYLFDDCFSALDFKTDAKVRAALREETKDATVIVVAQRVATIMDADQIIVLQKGEIAGIGTHKQLLNTCQIYREIVLSQLSGEELI

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Crispr_ID: NC_014377_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014377_8

1653314-1653777

Orphan

Consensus_repeat	Method
TTCGGCNTAAANGAAATNAAGAA	CRT

7 spacers

The CRISPR arrays of NC_014377_8

>merge|NC_014377|8|1653314-1653777|CRT
TTCGGCCTGAAGGAAATAAAGAAGGAGATTAAAGATATAGAGAAAAAGCTGGATGACAAAGACTTCGGCTTAAAAGAAATTAAGAAAGAAATAAAGCATATAGAGAAAAAACTCGATGATGATAAATTCGGCCTAAAGGAAATTAAGAAGGAGATAAAAGATATCGAAGATAAACTTGACAGCAAAGACTTCGGCTTAGAAGAAATTAAGAAAGAAGTAAAGGAAATAGAGAAAAAGCTCGATGATGACAAATTCGGCTTAAAAGAAATTAAGAAGGAGATAAAAGATATCGAAGATAAACTTGACAACAAGGATTTTGGATTAAAGGAAATAAAGAAGGAGATAAAAGATATCGAAGACAAACTTGACAGCAAGGATTTCGGCCTAAAGGAAATAAAGAAGGAAATAAAAGATATCGAAGACAAACTCGACAACAAGGATTTTGGCCTGAAAGAAATTAAGAA

>NC_014377|8|6|1653314-1653777|CRT
TTCGGCCTGAAGGAAATAAAGAA	GGAGATTAAAGATATAGAGAAAAAGCTGGATGACAAAGAC
TTCGGCTTAAAAGAAATTAAGAA	AGAAATAAAGCATATAGAGAAAAAACTCGATGATGATAAA
TTCGGCCTAAAGGAAATTAAGAA	GGAGATAAAAGATATCGAAGATAAACTTGACAGCAAAGAC
TTCGGCTTAGAAGAAATTAAGAA	AGAAGTAAAGGAAATAGAGAAAAAGCTCGATGATGACAAA
TTCGGCTTAAAAGAAATTAAGAA	GGAGATAAAAGATATCGAAGATAAACTTGACAACAAGGAT
TTTGGATTAAAGGAAATAAAGAA	GGAGATAAAAGATATCGAAGACAAACTTGACAGCAAGGAT
TTCGGCCTAAAGGAAATAAAGAA	GGAAATAAAAGATATCGAAGACAAACTCGACAACAAGGAT
TTTGGCCTGAAAGAAATTAAGAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_014377.1\|WP_013276436.1\|1666918_1667383_-\|D-proline-reductase	unknown	unknown	gnl\|CDD\|275273
NC_014377.1\|WP_013276432.1\|1660788_1662516_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_014377.1\|WP_013276434.1\|1663395_1664265_-\|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl\|CDD\|376667
NC_014377.1\|WP_041423913.1\|1642565_1642880_+\|DUF2935-domain-containing-protein	unknown	unknown	gnl\|CDD\|378573
NC_014377.1\|WP_013276423.1\|1642047_1642284_+\|DUF2935-domain-containing-protein	unknown	unknown	gnl\|CDD\|378573
NC_014377.1\|WP_187286567.1\|1652731_1652902_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226376
NC_014377.1\|WP_013276437.1\|1667395_1668274_-\|D-proline-reductase	unknown	unknown	gnl\|CDD\|275273
NC_014377.1\|WP_013276433.1\|1662515_1662968_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NC_014377.1\|WP_013276427.1\|1647395_1651043_+\|5'-nucleotidase-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|236505
NC_014377.1\|WP_013276426.1\|1646748_1647051_+\|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|367130
NC_014377.1\|WP_013276429.1\|1653935_1656785_-\|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl\|CDD\|234734
NC_014377.1\|WP_013276431.1\|1658923_1660792_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_014377.1\|WP_013276425.1\|1645078_1646299_-\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376564
NC_014377.1\|WP_013274925.1\|1664578_1665802_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376564
NC_014377.1\|WP_013276435.1\|1665871_1666912_-\|proline-racemase	unknown	unknown	gnl\|CDD\|184427
NC_014377.1\|WP_187286566.1\|1642261_1642432_+\|DUF2935-domain-containing-protein	unknown	unknown	gnl\|CDD\|378573
NC_014377.1\|WP_013276428.1\|1651622_1652693_-\|copper-amine-oxidase-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|377924
NC_014377.1\|WP_013276430.1\|1656801_1658817_-\|excinuclease-ABC-subunit-UvrB	unknown	unknown	gnl\|CDD\|235395
NC_014377.1\|WP_148218406.1\|1640603_1641890_-\|hydroxylamine-reductase	unknown	unknown	gnl\|CDD\|183427
NC_014377.1\|WP_013276421.1\|1639622_1640438_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669

Protein	Function_ID	Function_description	E-value
NC_014377.1\|WP_013276436.1\|1666918_1667383_-\|D-proline-reductase	gnl\|CDD\|275273	TIGR04480, D-proline_reductase_PrdA_proprotein, D-proline reductase (dithiol), PrdA proprotein. Members of this family are the PrdA proprotein. The polypeptide undergoes an autocatalytic cleavage that creates two subunits, one with a Cys-derived pyruvoyl motiety critical for activity. The D-proline reductase complex also contains a subunit derived from the prdB gene. The complex acts on D-proline, which may be supplied from L-proline by an active proline racemase encoded nearby.	3.66908e-60
NC_014377.1\|WP_013276432.1\|1660788_1662516_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	3.35456e-163
NC_014377.1\|WP_013276434.1\|1663395_1664265_-\|sulfite-exporter-TauE/SafE-family-protein	gnl\|CDD\|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	1.4617e-08
NC_014377.1\|WP_041423913.1\|1642565_1642880_+\|DUF2935-domain-containing-protein	gnl\|CDD\|378573	pfam11155, DUF2935, Domain of unknown function (DUF2935). This family of proteins with unknown function appears to be restricted to Firmicutes. The structure of this protein has been solved and each domain is composed of four alpha helices. A metal cluster composed of iron and magnesium lies between the two domains.	1.3347e-07
NC_014377.1\|WP_013276423.1\|1642047_1642284_+\|DUF2935-domain-containing-protein	gnl\|CDD\|378573	pfam11155, DUF2935, Domain of unknown function (DUF2935). This family of proteins with unknown function appears to be restricted to Firmicutes. The structure of this protein has been solved and each domain is composed of four alpha helices. A metal cluster composed of iron and magnesium lies between the two domains.	3.12479e-07
NC_014377.1\|WP_187286567.1\|1652731_1652902_-\|hypothetical-protein	gnl\|CDD\|226376	COG3858, COG3858, Predicted glycosyl hydrolase [General function prediction only].	0.00183139
NC_014377.1\|WP_013276437.1\|1667395_1668274_-\|D-proline-reductase	gnl\|CDD\|275273	TIGR04480, D-proline_reductase_PrdA_proprotein, D-proline reductase (dithiol), PrdA proprotein. Members of this family are the PrdA proprotein. The polypeptide undergoes an autocatalytic cleavage that creates two subunits, one with a Cys-derived pyruvoyl motiety critical for activity. The D-proline reductase complex also contains a subunit derived from the prdB gene. The complex acts on D-proline, which may be supplied from L-proline by an active proline racemase encoded nearby.	1.72115e-111
NC_014377.1\|WP_013276433.1\|1662515_1662968_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	2.83543e-26
NC_014377.1\|WP_013276427.1\|1647395_1651043_+\|5'-nucleotidase-C-terminal-domain-containing-protein	gnl\|CDD\|236505	PRK09419, PRK09419, multifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase/5'-nucleotidase.	3.56498e-144
NC_014377.1\|WP_013276426.1\|1646748_1647051_+\|carboxymuconolactone-decarboxylase-family-protein	gnl\|CDD\|367130	pfam02627, CMD, Carboxymuconolactone decarboxylase family. Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.	1.02367e-10
NC_014377.1\|WP_013276429.1\|1653935_1656785_-\|excinuclease-ABC-subunit-UvrA	gnl\|CDD\|234734	PRK00349, uvrA, excinuclease ABC subunit UvrA.	0
NC_014377.1\|WP_013276431.1\|1658923_1660792_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	0
NC_014377.1\|WP_013276425.1\|1645078_1646299_-\|IS110-family-transposase	gnl\|CDD\|376564	pfam01548, DEDD_Tnp_IS110, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family includes an amino-terminal region of the pilin gene inverting protein (PIVML) and of members of the IS111A/IS1328/IS1533 family of transposases. The C-terminus is represented by family pfam02371.	1.16737e-41
NC_014377.1\|WP_013274925.1\|1664578_1665802_+\|IS110-family-transposase	gnl\|CDD\|376564	pfam01548, DEDD_Tnp_IS110, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family includes an amino-terminal region of the pilin gene inverting protein (PIVML) and of members of the IS111A/IS1328/IS1533 family of transposases. The C-terminus is represented by family pfam02371.	6.47027e-47
NC_014377.1\|WP_013276435.1\|1665871_1666912_-\|proline-racemase	gnl\|CDD\|184427	PRK13969, PRK13969, proline racemase; Provisional.	0
NC_014377.1\|WP_187286566.1\|1642261_1642432_+\|DUF2935-domain-containing-protein	gnl\|CDD\|378573	pfam11155, DUF2935, Domain of unknown function (DUF2935). This family of proteins with unknown function appears to be restricted to Firmicutes. The structure of this protein has been solved and each domain is composed of four alpha helices. A metal cluster composed of iron and magnesium lies between the two domains.	4.3456e-08
NC_014377.1\|WP_013276428.1\|1651622_1652693_-\|copper-amine-oxidase-N-terminal-domain-containing-protein	gnl\|CDD\|377924	pfam07833, Cu_amine_oxidN1, Copper amine oxidase N-terminal domain. Copper amine oxidases catalyze the oxidative deamination of primary amines to the corresponding aldehydes, while reducing molecular oxygen to hydrogen peroxide. These enzymes are dimers of identical subunits, each comprising four domains. The N-terminal domain, which is absent in some amine oxidases, consists of a five-stranded antiparallel beta sheet twisted around an alpha helix. The D1 domains from the two subunits comprise the 'stalk' of the mushroom-shaped dimer, and interact with each other but do not pack tightly against each other.	2.61386e-36
NC_014377.1\|WP_013276430.1\|1656801_1658817_-\|excinuclease-ABC-subunit-UvrB	gnl\|CDD\|235395	PRK05298, PRK05298, excinuclease ABC subunit UvrB.	0
NC_014377.1\|WP_148218406.1\|1640603_1641890_-\|hydroxylamine-reductase	gnl\|CDD\|183427	PRK12310, PRK12310, hydroxylamine reductase; Provisional.	0
NC_014377.1\|WP_013276421.1\|1639622_1640438_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	9.44706e-35

>NC_014377.1|WP_187286567.1|1652731_1652902_-|hypothetical-protein
MYQAMARVSIPPEKLVLGIFTPTETPESMLTKVGIIKRYGLIDIAIWRLGLVTGEM
>NC_014377.1|WP_013276428.1|1651622_1652693_-|copper-amine-oxidase-N-terminal-domain-containing-protein
MARLSKIFREAEQNSQFVRLYFLERKFLKEVLPVRKKWLWNLLIVVLLITSLPGSVMADQPIAVTLNSEQLHFDVLPILENSRVLVPLRAIFETLGATVDWNGTTGTVTAAKGNSIVTLTVGENMAYKNGARVELDVPTKIVNGRTLVPVRFVSEALGERVYWIPKTSTVLIFSQDILTYNLNKLAQMVEQTKNQNLEEARKLVINNNGLWRYLLLTKEDWIAKSNILQYETTDLHNIWFPEGEALRFLARFVNRPYSLDQSPYEQTGSPIIDVVTFIDLSGEKPSLVWLAYLGKANEKIITFKDDTIDLTLKSYMEKWHGADWGYRVVNGTKPDLLGVKLQGYRPGPGYWFPINN
>NC_014377.1|WP_013276427.1|1647395_1651043_+|5'-nucleotidase-C-terminal-domain-containing-protein
MGRPVSKLLAFLISFCLLASSMAFPLQAAAQTQEVKITILATSDLHGNIYPFDYFTLKDSNVGLAKISTLVKKVRGENPNTLLLDNGDTIQGTPLVYYFTKVEPDKPHPMIKVMNAMGYDAMVVGNHEIQDFGYDWLEKVKNQANFPILAANLYLPDGQPAYTPYVIKEIAGVKVGILGLTSKNLPNWTTKQKLGPLTVKDAVEEAKKWVPQLRDKVDLLVVSAHMGFEVDLKTGASNGTAYENQAYALTKEVPGIDVLITGHSHMDIPPQLVNGVLVVQPYRWGSKLARLDITLLKTDNGWQIKEKMGEDLAVDGVEADPEVMALAGDYHEAALAYVNSTIGEAAGDFHGTYSRLKDTAIMDLIHKVQLKVTGADLSMAAMLPADPPTLKKGPLTVRDIYSLYIYENTLLKLEVTGKLIKEALEWSATYYNTYDFGAGSSPLINPDKRHYNFDTIQGVEYIMDISRPPGQRIRNLTYKGKPVRDDQKFTIAVNSYRASGGGGYTMFKDAPVLFQTTEEIRNLIIEYIKEQKVIYPETDNNWRLLPDHITHWAKEDVDRLVRNKALTGFSDGTFALEQPITRAQYAVLVARAYGIEPVKAPASRFKDVPGGHWASGYIETLAQKGLVNGKQAGLFAPEAPLTREEAAVILARIMGAAGTAKKENALAGFTDAWSVSPWAREALAFALEKGLLRGYPGGTLNPKKEVTRGEVAALVARGRYPVVTILHLNDLHGYITERLDNNNKPFGGMARVATVVAETRKQNPWTLMVDSGDHIQGAPIANFFYGSNVIEAYNAIQLDLATFGNHEFDWGRETIKNRMNEAKYDYICANLNDSKSGQLFTGKGYVVKEVGPVAIGFTGLITPELPTLVNPKGIEGLKVLDPVAAAGETVAALKKNGSVYNIVLSHMGVEEDKKLAQKVEGIDLIIGGHSHTRLDQPVEVSGVKIVQTGQHGENLGRIDLEFAVDRNGAKLLNMKYRLIPIDESIKPDEKIKNLIKPYEEELNAKMDEVIGEALVDLVGEREKVRTGETNLGNFIADWMRTALGADIAITNAGGIRASIAKGPIRVRDIYSVLPFDNLLVLVELTGSQVIEALENAYSKYPLADGRFAQISGIKVTIDPSKEPGQRVTEVLVNGVPIDPQAKYKVATNDFLYNGGDGYEVFKNGKFLGWSTGEWMRDELIRYLRQYPQVNPAVEGRIIIPKQQSRMLPAINNRAA
>NC_014377.1|WP_013276426.1|1646748_1647051_+|carboxymuconolactone-decarboxylase-family-protein
MPLPPFLASVEKNDPDFAKAIEGVFSSAMGPGALDQKTKLLIALALDAAHGAYQGVMNISKQLKNMGVKDEEIAEAIRIAYFAFGNSILASYSAAFSENK
>NC_014377.1|WP_013276425.1|1645078_1646299_-|IS110-family-transposase
MDVVYSHVCGLDVHKKSVVACVITPDGKEIRSFSTMTDDLFALKEFIKNKGCTVVAMKSTGSFWKPIYNLLELENLKILLVNAKHIKNVPGRKTDVKDAEWIASLLRHGLLKGSFVPDREQRELRELVRYRHGLVEERSRELNRIQKVLEGANIKLSSVVSDINGMSSRAILEALISGVDDPEILAELSHGKLKNKKEDLKRALKGFINYHQRKMLEIKLKHIDYLDEEIERLDEEIKNRMLPFEEDLALLDTIPGVGRRTAEQIIAEIGTNMDQFPSAAHLCSWAGLCPGQNESAGKRKSARTRKGNKKLRSALVEAARAASRAKDTYLSSQYHRIAARRGSNRAAVAVANSILTIVYHILKRKQPYIELGPNFYEEKRRNMVIRQSLKKLESLGLKVTVETIVS
>NC_014377.1|WP_041423913.1|1642565_1642880_+|DUF2935-domain-containing-protein
MALYFRPGQEAYMKEMLQWERQIRRLYNEIGKAFRASRSPEPFISISINIMKHWGGFLQRLLADLTRCTIPGRQMNVWPRIVDHMIRENNYFIEVLEILQKMRC
>NC_014377.1|WP_187286566.1|1642261_1642432_+|DUF2935-domain-containing-protein
MLDFIDFKGRVAAGIRACRILSILPAELVDHIRREALFFSEYWPGSKVGRDHLGGN
>NC_014377.1|WP_013276423.1|1642047_1642284_+|DUF2935-domain-containing-protein
MDIQHDLFLQREINFGVEIMKDHARFMRNAFDPTEEFLFNESDEFYRRFNFLTDELEPERDGAGMLLPAEPGAGLHRL
>NC_014377.1|WP_148218406.1|1640603_1641890_-|hydroxylamine-reductase
MFCYQCEQTPKGGCTRIGVCGKNEDISSLQDIIILGLKGISAYAVHARELGFTDPEVDATVQEALYMTLTNVNFNLKEHIDMAMKVGKATIKVMELLDKAHTSKFGIPEPVTVSQDKIEGHCILVTGHNLHALGELLKQSEGKGVNVYTHSEMLPAHGYPELRKYKHLKGNIGKSWTDQRKLFEEFPGAILGTTNCIMPIKGSYSDRFFSYGVAGLEGVQKIENDDFTPVIEKALSLPPANADSDKKVITGFHHETVLKIAPEVIEAVKAGKIRRFFVIAGCDTPGSGNDYYRQLALSLPKDCVILTTSCGKFRFNDVDYGTVPGTNIPRYIDLGQCNNSISAVKIAAALAEAFNCSVNDLPLTIVLSWFEQKAVAILLGLLSLGVKNIYIGPKAPEFFTPGVIKVLQDNFNLKLISDVNKDLPDMLG
>NC_014377.1|WP_013276421.1|1639622_1640438_-|alpha/beta-hydrolase
MGYYISVEQNVNIFVEDLDPGHGKPILFIHGWPLNHKQFEYQFNQLPKMGYRCIGIDLRGFGKSDRPWKGYSYNRLADDIRIVIDTLQLEDITLAGHSMGGAIAIRYMARHAGHKVSKLVLIGAAAFTRRPFGLTKEEVKRWERTWNDLIEATYIDRPKMLDGVGDVFFARYVTESFKDWFHGLGIEASGHATAMCAVSLRDEDLGQDLSKIYVPTGIFHGIHDKVCPFKFAELMHAQIKGSELIPFMYSGHGLFYEEWEKFNRELIRFIG
>NC_014377.1|WP_013276429.1|1653935_1656785_-|excinuclease-ABC-subunit-UvrA
MSKDKIIVKGARQHNLKNIDVEIPRDKLVVITGISGSGKSTLAFDTIYAEGQRRYVESLSAYARQFLGQMDKPDVDYIEGLSPAISIDQKTTSKNPRSTVGTVTEIYDYLRLLFARIGKPHCPRCGREISQQTVDQMVDAVMELPEGTRIQVLSPVIRGRKGEHLKLIEQIKKDGFVRIRVDGEIRETAEEIKLDKNKKHNIDIIVDRIIVKPGVESRLADSIETALARAGGLVVIDVIGDKEILFSQNFACPDCGISLEELSPRMFSFNSPYGACPACSGLGVNMEIDPDLVIPDRSKSVAEGAIVPWNSSPDGYYFQMLQAVLEHYGYDVETPIEKMDERMIEILLYGSDEVIDFYYESRYGSSRHFRGYFEGVINNLKRRYEETDSEWSREEIEEFMSTRPCPACKGARLKPESLAVKVGGLSIAQVTAFSIKDAMDFFNNLQLTEKERLIAHQVLKEIKSRLQFLIDVGLEYLTLDRPSGTLSGGESQRIRLATQIGSRLVGVLYILDEPSIGLHQRDNERLIKTLKELRDLGNTVLVVEHDEDTMRAADYIIDIGPGAGENGGRVVAAGPVEVIEKCEESLTGQYLSGRLTIPVPPVRRKPDGRWIVLKGCREHNLKNIDVKFPVGLFTCVTGVSGSGKSTLVNEILYKALREKLYKVKTRPGDFDDIEGVEYVDKVINIDQSPIGRTPRSNPATYTGVFNDIREVFSLTPEARMRGYKPGRFSFNVKGGRCEACKGDGIIKIEMHFLADVYVPCEVCKGKRYNRETLEVKYKGKSIADVLDMTVDEALEFFQNIPKIKRKLETLRDVGLGYIKLGQSSTTLSGGEAQRVKLATELSRKNNGGTVYILDEPTTGLHPADIKKLLDVLHRLVESGSTVIVIEHNLDVIKTADYIIDLGPEGGDGGGEVIALGTPEEVAANERSYTGYFLKKVLGMHEMKKVSSAG
>NC_014377.1|WP_013276430.1|1656801_1658817_-|excinuclease-ABC-subunit-UvrB
MGEFRVVSEFTPKGDQPKAIAALSEGIRKGYKFQTLLGATGTGKTFTIANLIEKVQKPTLVIAHNKTLAGQLCSELKEFFPNNAVEYFVSYYDYYQPEAYIPQTDTYIEKDASINDEIDKLRHSATAALFERRDVVIVASVSCIYSLGSPVDYENQVISLRPGMVKDRDEIIRRLVEIQYTRNEFEFSRNTFRVHGDILEIYPASFTERAIRVEFFGDVIDRITEIDTLTGEVMGERTHVSIFPASHYVTPRDKLEAAIKSIKEELEERLAELRAKGKLLEAARLEQRTNYDIEMLRETGYCKGIENYSRHLTGRKPGEPPFTLLDYFPRDYLIIIDESHVTIPQLRAMWAGDRSRKEALVEHGFRLPSAFDNRPLTFEEFEERINQVIFLSATPGPYELEKSSQVVEQIIRPTGLVDPEVEVRPTKGQIDDLIGEIRKRAEKDQRVLVTTLTKKMAEDLCDYLRESGIKVKYLHSEINTLERLQILRDLRLGKFDCLVGVNLLREGLDLPEVSLVAILDADKEGFLRSETSLIQTIGRAARNAEGRVIMYADTITESMARAISETNRRRMIQMEYNRKHGIVPTTVKKGIREMIEATKAAEERADYLPEKDLARMSKKELKAYLDKLEKEMKQAARNLEFERAAQLRDIIFEIKAQAFSVVRDRKTVSKS
>NC_014377.1|WP_013276431.1|1658923_1660792_-|ABC-transporter-ATP-binding-protein
MSAGPGGPVFTGRRHGGRGFVGGLPMVRPAEKPKDFKGTLGRLIKYLKPYAFEFFIVLILVLLSTVFNILGPKIMGEATTKLFEGLIAKRMHVPGAKIDFEYIAKILFILAGLYASSALFTYIQQYIMVSISQKTVLKMRNDVVEKLSKLPLKYFDSRTHGEILSRITNDIDNVSSTLQQSIIQLISAVVTIIGIVVMMLTINPVLTLITFVTLPLSIIATMSIAAKSQKLFAKQQRVLGELNGHVEETYGGHNIVKAFNREKDVLKIFNDINEELYNAAWKAQFMSGVIMPVMNFINNIGYVIVCVVGGIFVIKKILEIGDVQAFIQYSRQFNHPITQTANIVNIIQSTIASAERVFEILDEEEEVPDKAKFFLNDIKGKIKFENVKFSYKQNMPLIDNLNIEVSPGQTVAIVGPTGAGKTTLVNLLMRFYEIQDGRITIDGVDIRDISRANLRKIFGMVLQDTWLFSGTIKENIAYGKEGATDEEIIKAAKAAHAHHFIKTLPGGYDTLLNEEASNISQGQKQLITIARAFLADPEILILDEATSNVDTLTEIYIQKAMKNLMKGRTSFVIAHRLSTIKDADIILVVNNGKIIEKGTHKELLDRGGFYAELYKSQFLGAI
>NC_014377.1|WP_013276432.1|1660788_1662516_-|ABC-transporter-ATP-binding-protein
MIKLLKFLKPYRNYVIVSLILIFFQSISELYLPNLMSDIVDIGIVKGDIRYILQKGEIMLLVAAGGTVSAIVASYLSSQAAMGFGKILRNKIFSQVENFSLQEFDKFGTASLITRTTNDVNQIQMVIMITLRMVARAPLICIGGIILAVSKDARLSLILLITVPILAFLVFVLYKKAMPLFDAIQKKIDRVNLILRENLTGIRVIRAFNKIEYEKKRFNEANIDLTNMSIKVNRIMAWLMPAMMLLLNFTIIAVIWFGGIRIDKGTMQVGDLMAFIQYIIQIMFSLIMVSVVFVMLPRASASALRINEVLEIVPKIKEPEKPEEIKNIRGVIEFKDVTFSYPGADEPALKNISFKAEPGKLTAIIGGTGSGKSTVLNLIMRFYDADSGSILIDGVDIKLLPQTKLRDMIGYVPQKAVLFSGTIADNIRFGKNDAADEQIRKAACIAQATEFIFQMKDEFNSEISQGGKNLSGGQKQRLAIARAVVKRPKIYLFDDCFSALDFKTDAKVRAALREETKDATVIVVAQRVATIMDADQIIVLQKGEIAGIGTHKQLLNTCQIYREIVLSQLSGEELI
>NC_014377.1|WP_013276433.1|1662515_1662968_-|MarR-family-transcriptional-regulator
MEVIDPNSLYSLFLKVSRLHYLMTRELLEKINIYPGQPPLLLILYKHGGQSQRELAERLKVKPATITVMLNRIEKAGLIVRKQDDNDQRISRVYITEKGREICSKLREIILTIDRECFKDFNEQEKETLAMLFQKMTINLEKALNNQRVK
>NC_014377.1|WP_013276434.1|1663395_1664265_-|sulfite-exporter-TauE/SafE-family-protein
MTQAVLSVLGLLTLGFSYVFFKDTVKNKHTFSDASWAKLSLVGFIVNFFDTLGIGSFAPTTAFFKLMKLVPDKLIPGTLNVSMTIPVVLEALIFITVIQVEPITLISMLASATLGAVVGAGIVSKLPEKKIQIGMGIALLVVAMIFLAGMFNLMPVGGEAIGLTGTKLIIGVVGNFILGALMTIGIGLYAPCMALVYALGMSPRVAFPIMMGSCAFLMPAASIKFVQEGAYDRKASVAITIAGTIGVLIAAYIVKTLPLNLLKWLVVFVIIYTAITMLRSAFNNQVANE
>NC_014377.1|WP_013274925.1|1664578_1665802_+|IS110-family-transposase
MFYGGIDVAKHSHEVCLVNDSGDIVLKMHLDNNHKGMNKLLQALERLGLKPDDVKFCLEATGHYWLPIYCYLTNQGFELHVINPIQSDALRNLYVRKTKTDQKDALLLADLLRLGRAPETRLPSETTLKLQSLSRLRFEFVRQVGGLKNRVLGILDRIFPEYPDCFSDVFIRTSRELLKSYPEPEELAEVDLSELSAFLKEHSRGRFGEERAKKIQSLAKGTFGITMALDAFTLQLRLLVEQIEFIEEQIKVIEDAINEVMEELRPSKDTPYRHVIETIPGIGPVLAAAIIGEIGDISRFPNPRALVAYAGLDATVRASGLFEGTRNRMSKRGSPVLRNSLWLAAVSARRFNPELRAYYEQKRSQGKHSNVATGAVARKLVHLIYSLWKDNRPYDPDYQWSPPGKNA
>NC_014377.1|WP_013276435.1|1665871_1666912_-|proline-racemase
MRFSRYIIAVDSHTMGEPTRVVVGGIPHIPGRTMAEKKAYLEQNMDHIRTALMHEPRGHRDMFGSIITAPVNQEADFGIIFMDGGGYLNMCGHGSIGAVTVAIETGMVKPLSPVTHVKLDTPAGLIEARAELSDNIVKSVTIKNVPAFLYEPDVKIDVPGIGEITADISFGGSFFAIVDAKQLGIKVDPSNIDDLIKAGMAIKRAANEQIKVQHPEKEHIKTIDLVEIYDETENPNAHLKNVVIFGDGQADRSPCGTGTSAKMATLYAKGKLSLNQEFFYESIIGTVFKGKLVAETQVGPYKAVIPEITGSAYITGFNQFVIDPEDPVKYGFLLGKPGSGECCKMN
>NC_014377.1|WP_013276436.1|1666918_1667383_-|D-proline-reductase
MGVGPSTKETTLHHMRDPLVEIVQNDKDVDLVGIAVVGSPQDNLEKFYVAKRLGMLAEALGVDGVLIYAEGFGNQHVDFAAHIEELGKRGIPVVGLTFAGNGLVVENEYMEDIIDLDKAGQGMETEVVGQNCVVKADAVKSLKILKQKMKKKRG
>NC_014377.1|WP_013276437.1|1667395_1668274_-|D-proline-reductase
MFKISVKQAKSITMEMPEKLAQMALREKPQQSKSKAVTPLPKENVLRTLIWREFSVNNVQISNNTKIVDNTLYLDGALAQQALSINPLVKKVTIDVIKPGQHDVFTNTIMDIMPIATKVEGKMGEGITHCLRGVVVFLTGIDEAGRQIAEFGSSHGILKDKVAFGMPGTPKIDEIVLRIDVVIEKGAGMERRGPLAAHQVCDWILDHIRRELKKMPPQEAVFTQEFKDIRREGRPKVLIVKELGGQGAMHEKIIMPSEPGGVRGGKSIIDLGNVPVILTPNEVKDGGIHSMT

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_014377_8	8.4\|1653526\|40\|NC_014377\|CRT	1653526-1653565	40	NC_014377.1	1637029-1637068	0	1.0
NC_014377_8	8.2\|1653400\|40\|NC_014377\|CRT	1653400-1653439	40	NC_014377.1	1637155-1637194	1	0.975
NC_014377_8	8.5\|1653589\|40\|NC_014377\|CRT	1653589-1653628	40	NC_014377.1	1636903-1636942	1	0.975
NC_014377_8	8.6\|1653652\|40\|NC_014377\|CRT	1653652-1653691	40	NC_014377.1	1636903-1636942	1	0.975
NC_014377_8	8.1\|1653337\|40\|NC_014377\|CRT	1653337-1653376	40	NC_014377.1	1637218-1637257	2	0.95
NC_014377_8	8.5\|1653589\|40\|NC_014377\|CRT	1653589-1653628	40	NC_014377.1	1636966-1637005	2	0.95
NC_014377_8	8.7\|1653715\|40\|NC_014377\|CRT	1653715-1653754	40	NC_014377.1	1636903-1636942	2	0.95

1. spacer 8.4|1653526|40|NC_014377|CRT matches to position: 1637029-1637068, mismatch: 0, identity: 1.0

agaagtaaaggaaatagagaaaaagctcgatgatgacaaa	CRISPR spacer
agaagtaaaggaaatagagaaaaagctcgatgatgacaaa	Protospacer
****************************************

2. spacer 8.2|1653400|40|NC_014377|CRT matches to position: 1637155-1637194, mismatch: 1, identity: 0.975

agaaataaagcatatagagaaaaaactcgatgatgataaa	CRISPR spacer
agaaataaaggatatagagaaaaaactcgatgatgataaa	Protospacer
********** *****************************

3. spacer 8.5|1653589|40|NC_014377|CRT matches to position: 1636903-1636942, mismatch: 1, identity: 0.975

ggagataaaagatatcgaagataaacttgacaacaaggat	CRISPR spacer
ggagataaaagatatcgaagacaaacttgacaacaaggat	Protospacer
*********************.******************

4. spacer 8.6|1653652|40|NC_014377|CRT matches to position: 1636903-1636942, mismatch: 1, identity: 0.975

ggagataaaagatatcgaagacaaacttgacagcaaggat	CRISPR spacer
ggagataaaagatatcgaagacaaacttgacaacaaggat	Protospacer
********************************.*******

5. spacer 8.1|1653337|40|NC_014377|CRT matches to position: 1637218-1637257, mismatch: 2, identity: 0.95

ggagattaaagatatagagaaaaagctggatgacaaagac	CRISPR spacer
ggagattaaagatatagagaaaaaactggacgacaaagac	Protospacer
************************.*****.*********

6. spacer 8.5|1653589|40|NC_014377|CRT matches to position: 1636966-1637005, mismatch: 2, identity: 0.95

ggagataaaagatatcgaagataaacttgacaacaaggat	CRISPR spacer
ggagataaaagaaatcgaatataaacttgacaacaaggat	Protospacer
************ ****** ********************

7. spacer 8.7|1653715|40|NC_014377|CRT matches to position: 1636903-1636942, mismatch: 2, identity: 0.95

ggaaataaaagatatcgaagacaaactcgacaacaaggat	CRISPR spacer
ggagataaaagatatcgaagacaaacttgacaacaaggat	Protospacer
***.***********************.************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_014377_1	1.57\|77274\|37\|NC_014377\|PILER-CR,CRISPRCasFinder,CRT	77274-77310	37	NC_015937	Thermus phage TMA, complete genome	84615-84651	8	0.784
NC_014377_1	1.57\|77274\|37\|NC_014377\|PILER-CR,CRISPRCasFinder,CRT	77274-77310	37	AP011617	Thermus phage TMA DNA, complete genome	84615-84651	8	0.784
NC_014377_4	4.14\|542625\|37\|NC_014377\|PILER-CR,CRISPRCasFinder,CRT	542625-542661	37	KX119193	Helicobacter phage FrB58M, complete genome	5635-5671	8	0.784
NC_014377_3	3.8\|526944\|35\|NC_014377\|PILER-CR,CRISPRCasFinder,CRT	526944-526978	35	NZ_CP022367	Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence	636811-636845	9	0.743
NC_014377_3	3.8\|526944\|35\|NC_014377\|PILER-CR,CRISPRCasFinder,CRT	526944-526978	35	NZ_CP032322	Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence	1822194-1822228	9	0.743
NC_014377_4	4.7\|542160\|37\|NC_014377\|PILER-CR,CRISPRCasFinder,CRT	542160-542196	37	KM983327	Clostridium phage phiCT453A, complete genome	8201-8237	9	0.757
NC_014377_1	1.18\|74644\|38\|NC_014377\|PILER-CR,CRISPRCasFinder,CRT	74644-74681	38	NZ_CP054613	Paenibacillus cellulosilyticus strain KACC 14175 plasmid unnamed4, complete sequence	1475824-1475861	10	0.737
NC_014377_1	1.20\|74779\|38\|NC_014377\|PILER-CR,CRISPRCasFinder,CRT	74779-74816	38	NZ_CP054613	Paenibacillus cellulosilyticus strain KACC 14175 plasmid unnamed4, complete sequence	1475824-1475861	10	0.737
NC_014377_3	3.11\|527143\|37\|NC_014377\|PILER-CR,CRISPRCasFinder,CRT	527143-527179	37	MF417908	Uncultured Caudovirales phage clone 10S_1, partial genome	37909-37945	10	0.73
NC_014377_3	3.38\|528968\|36\|NC_014377\|PILER-CR	528968-529003	36	MN694132	Marine virus AFVG_250M1196, complete genome	31397-31432	10	0.722
NC_014377_3	3.59\|528959\|36\|NC_014377\|CRISPRCasFinder,CRT	528959-528994	36	MN694132	Marine virus AFVG_250M1196, complete genome	31397-31432	10	0.722
NC_014377_1	1.69\|78080\|37\|NC_014377\|PILER-CR,CRISPRCasFinder,CRT	78080-78116	37	NZ_CP040803	Streptococcus salivarius strain LAB813 plasmid pSAL813, complete sequence	43883-43919	11	0.703
NC_014377_1	1.69\|78080\|37\|NC_014377\|PILER-CR,CRISPRCasFinder,CRT	78080-78116	37	NZ_CP018188	Streptococcus salivarius strain ICDC2 plasmid, complete sequence	38034-38070	11	0.703
NC_014377_3	3.27\|528226\|37\|NC_014377\|PILER-CR	528226-528262	37	NZ_CP050943	Piscirickettsia salmonis strain Ps-2192A plasmid Ps2192A-p5, complete sequence	3030-3066	11	0.703
NC_014377_3	3.48\|528217\|37\|NC_014377\|CRISPRCasFinder,CRT	528217-528253	37	NZ_CP050943	Piscirickettsia salmonis strain Ps-2192A plasmid Ps2192A-p5, complete sequence	3030-3066	11	0.703

1. spacer 1.57|77274|37|NC_014377|PILER-CR,CRISPRCasFinder,CRT matches to NC_015937 (Thermus phage TMA, complete genome) position: , mismatch: 8, identity: 0.784

tataa-acaaacagtagggttggaacgacccgaattta	CRISPR spacer
-ataatattcttagtagggctggaacggcccgaattta	Protospacer
 **** *.   .*******.*******.**********

2. spacer 1.57|77274|37|NC_014377|PILER-CR,CRISPRCasFinder,CRT matches to AP011617 (Thermus phage TMA DNA, complete genome) position: , mismatch: 8, identity: 0.784

tataa-acaaacagtagggttggaacgacccgaattta	CRISPR spacer
-ataatattcttagtagggctggaacggcccgaattta	Protospacer
 **** *.   .*******.*******.**********

3. spacer 4.14|542625|37|NC_014377|PILER-CR,CRISPRCasFinder,CRT matches to KX119193 (Helicobacter phage FrB58M, complete genome) position: , mismatch: 8, identity: 0.784

attgatttattattggtatttaaagaaaatagatggt	CRISPR spacer
atctttttattattggtatttaagcaaaatagcggtt	Protospacer
**.  ******************. *******  * *

4. spacer 3.8|526944|35|NC_014377|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP022367 (Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence) position: , mismatch: 9, identity: 0.743

ccagcttggacggctcctgggtgctggacggcacc	CRISPR spacer
agcgcgaggacggctcctggctggtggacggcatg	Protospacer
   **  ************* ** *********.

5. spacer 3.8|526944|35|NC_014377|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP032322 (Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence) position: , mismatch: 9, identity: 0.743

ccagcttggacggctcctgggtgctggacggcacc	CRISPR spacer
agcgcgaggacggctcctggctggtggacggcatg	Protospacer
   **  ************* ** *********.

6. spacer 4.7|542160|37|NC_014377|PILER-CR,CRISPRCasFinder,CRT matches to KM983327 (Clostridium phage phiCT453A, complete genome) position: , mismatch: 9, identity: 0.757

aattccggctgatcaggtctttctacatctccatctc	CRISPR spacer
taggcttcatcatctggtctttctacatctccatctc	Protospacer
 *  *.   * *** **********************

7. spacer 1.18|74644|38|NC_014377|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP054613 (Paenibacillus cellulosilyticus strain KACC 14175 plasmid unnamed4, complete sequence) position: , mismatch: 10, identity: 0.737

-cgattggcgggtcaagagagtatgacaagagcagaagc	CRISPR spacer
tcggataat-actcaagatagtatgacaagagcagacgc	Protospacer
 **. *... . ****** ***************** **

8. spacer 1.20|74779|38|NC_014377|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP054613 (Paenibacillus cellulosilyticus strain KACC 14175 plasmid unnamed4, complete sequence) position: , mismatch: 10, identity: 0.737

-cgattggcgggtcaagagagtatgacaagagcagaagc	CRISPR spacer
tcggataat-actcaagatagtatgacaagagcagacgc	Protospacer
 **. *... . ****** ***************** **

9. spacer 3.11|527143|37|NC_014377|PILER-CR,CRISPRCasFinder,CRT matches to MF417908 (Uncultured Caudovirales phage clone 10S_1, partial genome) position: , mismatch: 10, identity: 0.73

ccgaaagaaaaagattgagtgtaaattaaatgaactt	CRISPR spacer
ggtggagagaatgattgagtgtaaattaaatgagtta	Protospacer
   ..***.** *********************..*

10. spacer 3.38|528968|36|NC_014377|PILER-CR matches to MN694132 (Marine virus AFVG_250M1196, complete genome) position: , mismatch: 10, identity: 0.722

cctaatagattatttagtatgttttttatctctcct	CRISPR spacer
tctaatagattcttttgtatgtttttttgttttaag	Protospacer
.********** *** ***********  .*.*

11. spacer 3.59|528959|36|NC_014377|CRISPRCasFinder,CRT matches to MN694132 (Marine virus AFVG_250M1196, complete genome) position: , mismatch: 10, identity: 0.722

cctaatagattatttagtatgttttttatctctcct	CRISPR spacer
tctaatagattcttttgtatgtttttttgttttaag	Protospacer
.********** *** ***********  .*.*

12. spacer 1.69|78080|37|NC_014377|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP040803 (Streptococcus salivarius strain LAB813 plasmid pSAL813, complete sequence) position: , mismatch: 11, identity: 0.703

gacaaaatctcaattccagtataccacaaaggaggaa	CRISPR spacer
taaaaaatctcaattacagtatagcacaagaagagtt	Protospacer
 * ************ ******* *****.....*

13. spacer 1.69|78080|37|NC_014377|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP018188 (Streptococcus salivarius strain ICDC2 plasmid, complete sequence) position: , mismatch: 11, identity: 0.703

gacaaaatctcaattccagtataccacaaaggaggaa	CRISPR spacer
taaaaaatctcaattacagtatagcacaagaagagtt	Protospacer
 * ************ ******* *****.....*

14. spacer 3.27|528226|37|NC_014377|PILER-CR matches to NZ_CP050943 (Piscirickettsia salmonis strain Ps-2192A plasmid Ps2192A-p5, complete sequence) position: , mismatch: 11, identity: 0.703

atcttccggttcttaattttgccgtatccacacccga	CRISPR spacer
actaaatcattcttaattttgccgtgttcacacccgg	Protospacer
*..   . .****************.*.********.

15. spacer 3.48|528217|37|NC_014377|CRISPRCasFinder,CRT matches to NZ_CP050943 (Piscirickettsia salmonis strain Ps-2192A plasmid Ps2192A-p5, complete sequence) position: , mismatch: 11, identity: 0.703

atcttccggttcttaattttgccgtatccacacccga	CRISPR spacer
actaaatcattcttaattttgccgtgttcacacccgg	Protospacer
*..   . .****************.*.********.

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

176304 : 220460

Bacillus_phage(18.18%)

tRNA,transposase,holin,integrase,coat

attL 175705:175719|attR 196678:196692

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
175705:175719	attL	NA	NA	NA	NA
WP_013275017.1\|176304_177585_+\|tRNA	serine--tRNA ligase	A0A1B1IVT2	uncultured_Mediterranean_phage	1.7e-95	48.1
WP_013275019.1\|179344_179587_-	DUF1540 domain-containing protein	NA	NA	NA	NA
WP_041423812.1\|179726_179915_+	hypothetical protein	NA	NA	NA	NA
WP_041423813.1\|179941_180214_+\|coat	spore coat protein	NA	NA	NA	NA
WP_041423814.1\|180423_181236_+	lipid II flippase Amj family protein	NA	NA	NA	NA
WP_013275021.1\|181282_182674_-	hypothetical protein	NA	NA	NA	NA
WP_049817872.1\|183205_183451_-\|integrase	tyrosine-type recombinase/integrase	A0A1B0T6A8	Bacillus_phage	1.7e-15	46.9
WP_049817873.1\|183526_183991_-\|integrase	site-specific integrase	A0A0U3U8Y8	Bacillus_phage	3.1e-15	33.8
WP_013275022.1\|184146_184485_+	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_013275023.1\|184598_184919_+	arsenite efflux transporter metallochaperone ArsD	NA	NA	NA	NA
WP_013275024.1\|184918_185806_+	ArsA family ATPase	NA	NA	NA	NA
WP_041423815.1\|185798_186692_+	TRC40/GET3/ArsA family transport-energizing ATPase	NA	NA	NA	NA
WP_013275026.1\|186805_187039_+	hypothetical protein	NA	NA	NA	NA
WP_013275027.1\|187334_188564_+\|transposase	IS21 family transposase	A0A2L1IVA1	Escherichia_phage	4.7e-42	36.4
WP_013275028.1\|188560_189331_+	ATP-binding protein	U5N3V8	Enterobacteria_phage	1.2e-64	52.5
WP_013275029.1\|189378_190233_-\|transposase	IS3 family transposase	A0A0C5AEA5	Paenibacillus_phage	1.4e-98	73.5
WP_013275030.1\|190271_190955_-	helix-turn-helix domain-containing protein	A0A0C5AJ29	Paenibacillus_phage	4.4e-66	55.9
WP_013275031.1\|191204_192623_-	glycosyltransferase	NA	NA	NA	NA
WP_013275032.1\|192916_193834_+	substrate-binding domain-containing protein	NA	NA	NA	NA
WP_013275033.1\|193852_194560_+	ABC transporter permease	NA	NA	NA	NA
WP_148218350.1\|194540_195287_+	ATP-binding cassette domain-containing protein	A0A285PWH2	Cedratvirus	7.8e-16	27.6
WP_148218351.1\|195394_195964_+	VTT domain-containing protein	NA	NA	NA	NA
WP_013275036.1\|196124_197456_+	S-layer homology domain-containing protein	NA	NA	NA	NA
196678:196692	attR	NA	NA	NA	NA
WP_013275037.1\|197598_197772_+	S-layer homology domain-containing protein	NA	NA	NA	NA
WP_013275038.1\|198350_198719_+	response regulator	NA	NA	NA	NA
WP_013275039.1\|198744_199710_+	GHKL domain-containing protein	NA	NA	NA	NA
WP_013275040.1\|199918_201184_+	transcription termination factor Rho	NA	NA	NA	NA
WP_013275041.1\|201189_201516_-	MazG-like family protein	NA	NA	NA	NA
WP_013275042.1\|201512_201968_-	nucleoside recognition domain-containing protein	NA	NA	NA	NA
WP_187286592.1\|201982_202399_-	nucleoside recognition protein	NA	NA	NA	NA
WP_013275044.1\|202764_204384_+	carbon starvation protein A	NA	NA	NA	NA
WP_013275045.1\|204461_204962_+	hypothetical protein	NA	NA	NA	NA
WP_013275046.1\|205043_206774_+	sensor histidine kinase	Q9EYF3	Enterobacteria_phage	2.5e-81	37.7
WP_013275047.1\|206745_207510_+	response regulator transcription factor	NA	NA	NA	NA
WP_013275048.1\|207672_207861_+	ferredoxin	NA	NA	NA	NA
WP_013275049.1\|208132_209227_-	D-alanine--D-alanine ligase	NA	NA	NA	NA
WP_013275050.1\|209483_209630_+	hypothetical protein	NA	NA	NA	NA
WP_013275051.1\|209652_210072_-	HEPN domain-containing protein	NA	NA	NA	NA
WP_013275052.1\|210068_210560_-	nucleotidyltransferase domain-containing protein	NA	NA	NA	NA
WP_013275053.1\|210887_212039_+	iron-containing alcohol dehydrogenase	NA	NA	NA	NA
WP_013275054.1\|212074_213250_-	FprA family A-type flavoprotein	NA	NA	NA	NA
WP_013275055.1\|213261_213765_-	ferritin family protein	NA	NA	NA	NA
WP_041423979.1\|213767_214979_-	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_013275057.1\|215026_215185_-	rubredoxin	NA	NA	NA	NA
WP_041423816.1\|216190_216574_-	ferritin-like domain-containing protein	NA	NA	NA	NA
WP_187286575.1\|216801_216948_-	hypothetical protein	NA	NA	NA	NA
WP_013275059.1\|217056_217581_+	methylated-DNA--[protein]-cysteine S-methyltransferase	A0A0G2Y1B6	Acanthamoeba_polyphaga_mimivirus	2.5e-21	56.3
WP_013275061.1\|217865_218141_+	rubrerythrin	NA	NA	NA	NA
WP_187286576.1\|218305_219307_+	glycine/betaine ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_013275063.1\|219332_220460_+\|holin	betaine/proline/choline family ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	5.5e-29	36.5

DBSCAN-SWA_2

1218624 : 1266079

Clostridioides_phage(14.29%)

protease,tRNA,portal,integrase,capsid,transposase

attL 1262288:1262305|attR 1273770:1273787

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013276041.1\|1218624_1220064_-\|tRNA	proline--tRNA ligase	A0A2K9L0T2	Tupanvirus	1.5e-111	42.9
WP_013276042.1\|1220420_1220750_-	hypothetical protein	NA	NA	NA	NA
WP_013276043.1\|1220739_1221210_-	hypothetical protein	NA	NA	NA	NA
WP_148218460.1\|1221440_1222508_-	flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase	NA	NA	NA	NA
WP_013276045.1\|1222555_1223557_-\|protease	RIP metalloprotease RseP	NA	NA	NA	NA
WP_013276046.1\|1223578_1224637_-	sporulation integral membrane protein YtvI	NA	NA	NA	NA
WP_013276047.1\|1224627_1225452_-	phosphatidate cytidylyltransferase	NA	NA	NA	NA
WP_013276048.1\|1225452_1226199_-	isoprenyl transferase	R9W0U9	Flavobacterium_phage	3.2e-25	45.1
WP_013276049.1\|1226461_1227019_-	ribosome recycling factor	NA	NA	NA	NA
WP_013276050.1\|1227023_1227737_-	UMP kinase	NA	NA	NA	NA
WP_013276051.1\|1227849_1228464_-	translation elongation factor Ts	NA	NA	NA	NA
WP_013276052.1\|1228541_1229243_-	30S ribosomal protein S2	NA	NA	NA	NA
WP_013276053.1\|1229385_1230357_-	2-hydroxyglutaryl-CoA dehydratase	NA	NA	NA	NA
WP_013276054.1\|1230331_1231441_-	hypothetical protein	NA	NA	NA	NA
WP_013276055.1\|1231412_1232423_-	hypothetical protein	NA	NA	NA	NA
WP_013276056.1\|1232488_1232860_-	hypothetical protein	NA	NA	NA	NA
WP_013276057.1\|1232872_1233226_-	stage V sporulation protein AE	NA	NA	NA	NA
WP_013276058.1\|1233248_1234259_-	stage V sporulation protein AD	NA	NA	NA	NA
WP_013276059.1\|1234269_1234722_-	stage V sporulation protein AC	NA	NA	NA	NA
WP_013276060.1\|1234736_1234949_-	dodecin domain-containing protein	NA	NA	NA	NA
WP_013276061.1\|1234945_1235134_-	hypothetical protein	NA	NA	NA	NA
WP_013276062.1\|1235221_1235947_-	RNA polymerase sporulation sigma factor SigF	A0A0A0RV91	Bacillus_phage	6.6e-52	50.4
WP_013276063.1\|1235968_1236400_-	anti-sigma F factor	NA	NA	NA	NA
WP_041423888.1\|1236415_1236751_-	anti-sigma F factor antagonist	NA	NA	NA	NA
WP_148218461.1\|1236863_1238000_-	serine hydrolase	NA	NA	NA	NA
WP_041424123.1\|1238095_1238983_-	site-specific tyrosine recombinase XerD	A0A0K2CP59	Brevibacillus_phage	4.9e-41	32.9
WP_013276067.1\|1239041_1239668_-	stage II sporulation protein M	NA	NA	NA	NA
WP_013276068.1\|1239728_1240901_-	hypothetical protein	NA	NA	NA	NA
WP_013276069.1\|1240900_1241443_-	NUDIX hydrolase	NA	NA	NA	NA
WP_013276070.1\|1241385_1242537_-	DUF3866 family protein	NA	NA	NA	NA
WP_013276071.1\|1242558_1243347_-	hypothetical protein	NA	NA	NA	NA
WP_013276072.1\|1243357_1244071_-	copper transporter	NA	NA	NA	NA
WP_013276073.1\|1244082_1245210_-	hypothetical protein	NA	NA	NA	NA
WP_013276074.1\|1246935_1247766_-	hypothetical protein	E5DV53	Deep-sea_thermophilic_phage	2.0e-81	55.4
WP_013276075.1\|1247789_1248392_-	DUF4355 domain-containing protein	A0A2H4J4P4	uncultured_Caudovirales_phage	4.2e-28	42.6
WP_013276076.1\|1248569_1249451_-\|capsid	minor capsid protein	A0A1P8BLD7	Lactococcus_phage	9.5e-21	27.3
WP_013276077.1\|1249443_1250721_-\|portal	phage portal protein	A0A1V0DZW8	Clostridioides_phage	8.8e-100	48.4
WP_013276078.1\|1250738_1252526_-	phage protein	A0A1V0DZW7	Clostridioides_phage	1.2e-131	43.9
WP_013276079.1\|1253069_1253462_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_013276080.1\|1253728_1253935_-	hypothetical protein	NA	NA	NA	NA
WP_013276081.1\|1254004_1254784_-	hypothetical protein	NA	NA	NA	NA
WP_148218395.1\|1254852_1255398_-	hypothetical protein	NA	NA	NA	NA
WP_013275027.1\|1255496_1256726_+\|transposase	IS21 family transposase	A0A2L1IVA1	Escherichia_phage	4.7e-42	36.4
WP_013275028.1\|1256722_1257493_+	ATP-binding protein	U5N3V8	Enterobacteria_phage	1.2e-64	52.5
WP_041423890.1\|1257520_1258894_-	hypothetical protein	A0A2I7QLM0	Vibrio_phage	8.4e-16	31.6
WP_013276082.1\|1258940_1259111_-	hypothetical protein	NA	NA	NA	NA
WP_013276083.1\|1259159_1259615_-	hypothetical protein	NA	NA	NA	NA
WP_187286562.1\|1259776_1259941_-	hypothetical protein	NA	NA	NA	NA
WP_013276085.1\|1259927_1260119_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_187286563.1\|1260310_1261483_-	hypothetical protein	NA	NA	NA	NA
WP_083768520.1\|1261890_1263405_+\|transposase	IS21 family transposase	NA	NA	NA	NA
1262288:1262305	attL	NA	NA	NA	NA
WP_013275115.1\|1263398_1264130_+	ATP-binding protein	U5N3V8	Enterobacteria_phage	1.9e-30	35.2
WP_041423892.1\|1264253_1264514_-	hypothetical protein	NA	NA	NA	NA
WP_013276087.1\|1264840_1265068_-	hypothetical protein	NA	NA	NA	NA
WP_013276088.1\|1265107_1266079_-\|integrase	tyrosine-type recombinase/integrase	A5X9F3	Aeromonas_virus	1.4e-09	27.4
1273770:1273787	attR	NA	NA	NA	NA

DBSCAN-SWA_3

1469586 : 1481448

Streptococcus_phage(22.22%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013276279.1\|1469586_1470222_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	1.7e-24	37.5
WP_013276280.1\|1470209_1471247_-	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	2.8e-80	46.0
WP_041424156.1\|1471259_1472663_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	3.8e-56	34.9
WP_013276282.1\|1472662_1474876_-	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	5.3e-177	46.4
WP_013276283.1\|1474859_1475579_-	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_013276284.1\|1475575_1475830_-	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_013276285.1\|1475911_1476616_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A1D7SPE1	Cyanophage	1.2e-42	45.4
WP_013276286.1\|1476612_1477116_-	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	1.9e-26	45.9
WP_041423905.1\|1477538_1477847_+\|transposase	IS1182 family transposase	A0A1X9I5T2	Streptococcus_phage	3.2e-24	60.7
WP_083768520.1\|1477993_1479508_+\|transposase	IS21 family transposase	NA	NA	NA	NA
WP_013276287.1\|1479559_1480234_+	ATP-binding protein	U5N3V8	Enterobacteria_phage	3.0e-30	35.3
WP_049817910.1\|1480293_1481448_+\|transposase	IS1182 family transposase	A0A1X9I5T2	Streptococcus_phage	9.4e-85	44.9

DBSCAN-SWA_4

1675992 : 1683647

Staphylococcus_phage(42.86%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013276446.1\|1675992_1677240_-	S41 family peptidase	A0A0R6PIZ1	Moraxella_phage	9.7e-27	30.7
WP_148218476.1\|1677309_1678092_-	peptidoglycan DD-metalloendopeptidase family protein	G9BW84	Planktothrix_phage	2.8e-24	42.3
WP_041423914.1\|1678479_1679352_-	ABC transporter permease	NA	NA	NA	NA
WP_013276449.1\|1679341_1680028_-	cell division ATP-binding protein FtsE	G9BWD6	Planktothrix_phage	3.0e-30	36.1
WP_013276450.1\|1680148_1680628_-	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	3.9e-37	53.4
WP_013276451.1\|1680650_1681853_-	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	5.3e-115	53.4
WP_013276452.1\|1681893_1682541_-	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	7.4e-39	41.9
WP_013276453.1\|1682525_1683647_-	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2I2L4R9	Orpheovirus	5.6e-58	36.5

DBSCAN-SWA_5

1963224 : 1972813

Enterobacteria_phage(33.33%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013276696.1\|1963224_1965276_-	UvrD-helicase domain-containing protein	R4VJW1	Alteromonas_phage	3.3e-24	27.7
WP_083768506.1\|1965400_1966678_-	DNA recombination protein RmuC	NA	NA	NA	NA
WP_148218482.1\|1967126_1967333_-	DUF47 family protein	NA	NA	NA	NA
WP_187286570.1\|1967452_1967851_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_013275027.1\|1967949_1969179_+\|transposase	IS21 family transposase	A0A2L1IVA1	Escherichia_phage	4.7e-42	36.4
WP_013275028.1\|1969175_1969946_+	ATP-binding protein	U5N3V8	Enterobacteria_phage	1.2e-64	52.5
WP_013276698.1\|1969973_1970120_-	hypothetical protein	NA	NA	NA	NA
WP_013276699.1\|1970408_1971092_+	helix-turn-helix domain-containing protein	A0A0C5AJ29	Paenibacillus_phage	6.8e-67	57.3
WP_013276700.1\|1971130_1972003_+\|transposase	IS3 family transposase	A0A0C5AEA5	Paenibacillus_phage	1.9e-98	73.5
WP_013275115.1\|1972081_1972813_-	ATP-binding protein	U5N3V8	Enterobacteria_phage	1.9e-30	35.2

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_014377

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection