CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number
NC_012778	[Eubacterium] eligens ATCC 27750, complete sequence	4 crisprs	DEDDh,cas3,cas2,cas1,cas12a,csa3,cas3HD	2	2	0
NC_012780	[Eubacterium] eligens ATCC 27750 plasmid unnamed, complete sequence	1 crisprs	csa3,cas2,WYL	0	1	1
NC_012782	[Eubacterium] eligens ATCC 27750 plasmid unnamed, complete sequence	0 crisprs	RT,WYL,cas4	0	0	2

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_012778_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012778_1

752019-752104

Orphan

Consensus_repeat	Method
AGCCACGGAGGAAGTCCAAAAGGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012778_1

>merge|NC_012778|1|752019-752104|CRISPRCasFinder
AGCCACGGAGGAAGTCCAAAAGGAGTGAGAAATAGAGGCGGATTGGACATTGACGCGGTGGAAGCCACGGAGGAAGTCCAAAAGGA

>NC_012778|1|1|752019-752104|CRISPRCasFinder
AGCCACGGAGGAAGTCCAAAAGGA	GTGAGAAATAGAGGCGGATTGGACATTGACGCGGTGGA
AGCCACGGAGGAAGTCCAAAAGGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_012778.1\|WP_012738978.1\|739522_740443_+\|sigma-E-processing-peptidase-SpoIIGA	unknown	unknown	gnl\|CDD\|377033
NC_012778.1\|WP_012738993.1\|759429_760260_+\|uroporphyrinogen-III-synthase	unknown	unknown	gnl\|CDD\|119440
NC_012778.1\|WP_012738983.1\|745063_745849_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|378964
NC_012778.1\|WP_012738998.1\|763402_763717_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NC_012778.1\|WP_041688020.1\|761845_763261_+\|spore-germination-protein	unknown	unknown	gnl\|CDD\|377020
NC_012778.1\|WP_041688018.1\|760773_761706_+\|cysteine-synthase-A	unknown	unknown	gnl\|CDD\|273463
NC_012778.1\|WP_041688009.1\|738264_739434_+\|cell-division-protein-FtsZ	unknown	unknown	gnl\|CDD\|236468
NC_012778.1\|WP_012738985.1\|748142_751703_+\|pyruvate:ferredoxin-(flavodoxin)-oxidoreductase	unknown	unknown	gnl\|CDD\|131231
NC_012778.1\|WP_041688016.1\|753202_754939_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_012778.1\|WP_012738981.1\|742047_743862_+\|elongation-factor-4	unknown	unknown	gnl\|CDD\|235462
NC_012778.1\|WP_012738991.1\|757312_758530_+\|glutamyl-tRNA-reductase	unknown	unknown	gnl\|CDD\|234592
NC_012778.1\|WP_041688518.1\|740485_741226_+\|RNA-polymerase-sporulation-sigma-factor-SigE	unknown	unknown	gnl\|CDD\|236228
NC_012778.1\|WP_012738992.1\|758538_759426_+\|hydroxymethylbilane-synthase	unknown	unknown	gnl\|CDD\|234612
NC_012778.1\|WP_012738990.1\|756013_757288_+\|glutamate-1-semialdehyde-2,1-aminomutase	unknown	unknown	gnl\|CDD\|234607
NC_012778.1\|WP_041688012.1\|743854_745009_+\|oxygen-independent-coproporphyrinogen-III-oxidase	unknown	unknown	gnl\|CDD\|180263
NC_012778.1\|WP_012738984.1\|746115_747864_+\|ammonium-transporter	unknown	unknown	gnl\|CDD\|223083
NC_012778.1\|WP_012738980.1\|741280_742048_+\|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl\|CDD\|119407
NC_012778.1\|WP_012738987.1\|752257_752992_+\|hypothetical-protein	unknown	unknown	unknown
NC_012778.1\|WP_012738976.1\|737429_738185_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224505
NC_012778.1\|WP_041688522.1\|755006_755972_+\|porphobilinogen-synthase	unknown	unknown	gnl\|CDD\|236450

Protein	Function_ID	Function_description	E-value
NC_012778.1\|WP_012738978.1\|739522_740443_+\|sigma-E-processing-peptidase-SpoIIGA	gnl\|CDD\|377033	pfam03419, Peptidase_U4, Sporulation factor SpoIIGA.	9.73509e-53
NC_012778.1\|WP_012738993.1\|759429_760260_+\|uroporphyrinogen-III-synthase	gnl\|CDD\|119440	cd06578, HemD, Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in the human uroporphyrinogen-III synthase gene cause congenital erythropoietic porphyria, a recessive inborn error of metabolism also known as Gunther disease.	2.99824e-25
NC_012778.1\|WP_012738983.1\|745063_745849_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|378964	pfam12833, HTH_18, Helix-turn-helix domain.	4.21212e-14
NC_012778.1\|WP_012738998.1\|763402_763717_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	5.35773e-07
NC_012778.1\|WP_041688020.1\|761845_763261_+\|spore-germination-protein	gnl\|CDD\|377020	pfam03323, GerA, Bacillus/Clostridium GerA spore germination protein.	1.05648e-158
NC_012778.1\|WP_041688018.1\|760773_761706_+\|cysteine-synthase-A	gnl\|CDD\|273463	TIGR01136, Cysteine_synthase, cysteine synthase. This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and CysM) from cystathionine beta-synthase, a protein found primarily in eukaryotes and carrying a C-terminal CBS domain lacking from this protein. Bacterial proteins lacking the CBS domain but otherwise showing resemblamnce to cystathionine beta-synthases and considerable phylogenetic distance from known cysteine synthases were excluded from the seed and score below the trusted cutoff. [Amino acid biosynthesis, Serine family].	1.34722e-160
NC_012778.1\|WP_041688016.1\|753202_754939_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	0
NC_012778.1\|WP_012738985.1\|748142_751703_+\|pyruvate:ferredoxin-(flavodoxin)-oxidoreductase	gnl\|CDD\|131231	TIGR02176, pyruvate_flavodoxin/ferrodoxin_oxidoreductase, pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric. This model represents a single chain form of pyruvate:ferredoxin (or flavodoxin) oxidoreductase. This enzyme may transfer electrons to nitrogenase in nitrogen-fixing species. Portions of this protein are homologous to gamma subunit of the four subunit pyruvate:ferredoxin (flavodoxin) oxidoreductase.	0
NC_012778.1\|WP_041688009.1\|738264_739434_+\|cell-division-protein-FtsZ	gnl\|CDD\|236468	PRK09330, PRK09330, cell division protein FtsZ; Validated.	0
NC_012778.1\|WP_012738990.1\|756013_757288_+\|glutamate-1-semialdehyde-2,1-aminomutase	gnl\|CDD\|234607	PRK00062, PRK00062, glutamate-1-semialdehyde 2,1-aminomutase.	0
NC_012778.1\|WP_012738984.1\|746115_747864_+\|ammonium-transporter	gnl\|CDD\|223083	COG0004, AmtB, Ammonia permease [Inorganic ion transport and metabolism].	8.58808e-134
NC_012778.1\|WP_012738991.1\|757312_758530_+\|glutamyl-tRNA-reductase	gnl\|CDD\|234592	PRK00045, hemA, glutamyl-tRNA reductase; Reviewed.	1.14156e-108
NC_012778.1\|WP_041688518.1\|740485_741226_+\|RNA-polymerase-sporulation-sigma-factor-SigE	gnl\|CDD\|236228	PRK08301, PRK08301, RNA polymerase sporulation sigma factor SigE.	9.24782e-150
NC_012778.1\|WP_012738992.1\|758538_759426_+\|hydroxymethylbilane-synthase	gnl\|CDD\|234612	PRK00072, hemC, porphobilinogen deaminase; Reviewed.	1.03883e-142
NC_012778.1\|WP_041688012.1\|743854_745009_+\|oxygen-independent-coproporphyrinogen-III-oxidase	gnl\|CDD\|180263	PRK05799, PRK05799, oxygen-independent coproporphyrinogen III oxidase.	2.03164e-155
NC_012778.1\|WP_012738980.1\|741280_742048_+\|N-acetylmuramoyl-L-alanine-amidase	gnl\|CDD\|119407	cd02696, MurNAc-LAA, N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino acids in certain cell wall glycopeptides. These proteins are Zn-dependent peptidases with highly conserved residues involved in cation co-ordination. MurNAc-LAA in this family is one of several peptidoglycan hydrolases (PGHs) found in bacterial and bacteriophage or prophage genomes that are involved in the degradation of the peptidoglycan. In Escherichia coli, there are five MurNAc-LAAs present: AmiA, AmiB, AmiC and AmiD that are periplasmic, and AmpD that is cytoplasmic. Three of these (AmiA, AmiB and AmiC) belong to this family, the other two (AmiD and AmpD) do not. E. coli AmiA, AmiB and AmiC play an important role in cleaving the septum to release daughter cells after cell division. In general, bacterial MurNAc-LAAs are members of the bacterial autolytic system and carry a signal peptide in their N-termini that allows their transport across the cytoplasmic membrane. However, the bacteriophage MurNAc-LAAs are endolysins since these phage-encoded enzymes break down bacterial peptidoglycan at the terminal stage of the phage reproduction cycle. As opposed to autolysins, almost all endolysins have no signal peptides and their translocation through the cytoplasmic membrane is thought to proceed with the help of phage-encoded holin proteins. The amidase catalytic module is fused to another functional module (cell wall binding module or CWBM) either at the N- or C-terminus, which is responsible for high affinity binding of the protein to the cell wall.	1.42917e-47
NC_012778.1\|WP_012738981.1\|742047_743862_+\|elongation-factor-4	gnl\|CDD\|235462	PRK05433, PRK05433, GTP-binding protein LepA; Provisional.	0
NC_012778.1\|WP_012738976.1\|737429_738185_+\|hypothetical-protein	gnl\|CDD\|224505	COG1589, FtsQ, Cell division septal protein [Cell envelope biogenesis, outer membrane].	4.22494e-07
NC_012778.1\|WP_041688522.1\|755006_755972_+\|porphobilinogen-synthase	gnl\|CDD\|236450	PRK09283, PRK09283, porphobilinogen synthase.	0

>NC_012778.1|WP_012738985.1|748142_751703_+|pyruvate:ferredoxin-(flavodoxin)-oxidoreductase
MARQKQSMDGNTAAAHVAYAYTEVAGIYPITPSSPMADVVDTWSAQGLKNIFGNTVKVVEMESEAGAAGTVHGSLATGALTTTFTASQGLLLMIPNMYKIAGEQLPCVFDVSARTVSTHALNIFGDHSDVYACRQTGFAMLCETNPQEVMDLSPVAHCAALEGKTPFINFFDGFRTSHEIQKIEKWDYEDLKDMCPMDAVDEFRAHALNPNHPAARGSHENGDIFFQHREACNSLYDELPNVVEKYMGKVNEKLGTDYDLFNYYGAPDADRVIVAMGSINDVAEEVIDYLTAKGEKVGLVKVRLYRPWSSKHLLKVIPKTVKKMAVLDRTKEPGSLGEPLYLDVATTLREAGLNDIVLVGGRYGLGSKDTPPSSVFAIYKELEKDEPKSRFTIGIVDDVTNLSLPEVKPAPITSAPGTVECKFWGLGGDGTVGANKNSTKIIGDHTDKYIQAYFQYDSKKTGGVTISHLRFGDNPIKSPYYINQADFVACHNPSYVIKGYKMVQDVKPGGIFMINCQWSDEELNQHMPAEAKQYIAKNNIQLYTINAIDKAIEIGMGKRTNTILQSAFFKLANVMPIDKAVDYMKQAAKKSYSKKGDAVVEMNYKAIDAGVDAVHKVEVPADWATATDDKKAADRTGRPATVKMVNELLDPIGLMDGDSLPVSAFKDIADGQFETGASAYEKRGTAVMVPEWDPTACVQCNSCAFVCSHATIRPFILSTDEVNAAPSNIKLADSKHAIDKTMKYTMSVSPLDCMGCGECVTVCPKAGEAIKMVPQESQADEQPVFNYLVENVGKKEITPALVNGPIGSQYNQPLLEFSGSCAGCAETSYARLITQLFGEQMYISNATGCSSIWGNPAATSPYTVNKDSKKGPAWSNSLFEDNAEHGFGMYLGQKTLRDQLIAQVEEMAASDKASDDFKAAAAKYLETKNDTKANTPAADALIAELEKAAKDGCPVAPQILAKKNFLAKKSVWIFGGDGWAYDIGFGGLDHVLASGENVNVFVFDTEMYSNTGGQASKASNIGEVCQFAAAGKEIGKKSLSEIAMTYGYVYVAQIALGANPAQAVKVIQEAESYNGPSLIIGYAPCELHGIAKGGMNHCQDEMKKAVKAGYWNLFSFNPALKAEGKNPFTLTSKEGDGTYQDFLNNEARYTRLVKPFPERAERLFAKSEEVAKERYDHLTKLVELYK
>NC_012778.1|WP_012738984.1|746115_747864_+|ammonium-transporter
MVMQEILSAVDAELFGVWFLIGAALVFWMQAGFAMVETGFTRAKNSGNIIMKNLMDFCIGTVMFVLIGFSFLLGEDLLGFIGKPGFDIFTAYKDFDFSSFVFNLVFCATTATIVSGAMAERTKFLSYCVYSAVISALIYPIEAHWIWGGGWLAQLGFHDFAGSCCIHMVGGISALIGAKILGPRIGKFEKDANGKVIKVNAFPGHNIPLGALGVFILWFGWYGFNGAAATTIEDLGSIFLTTTVAPAVATVTCMIFTWIRYGKPDVSMCLNASLAGLVGITAPCDVTDAFGATMIGIVSGLLVVFGVWLLDYKLHVDDPVGAVAVHMMNGIWGTIAVGLFATSSAPGYAIALEGGSIKGEGLFYGGGFTQLGLQLLGFVSVAAWAVVCMVIVFTVIKATIGLRASKEEEIRGLDIMEHGLSSAYAGFEFGGMDFVDGDVDVIGSESMEASVPALVKTSDAGDGKKITKVEILMKQERFERFKKAMNDIGVTGMTVTQVLGCGTQKGAPEYYRGVPMDIQLLPKTQVEMVISSVPVMDVINATRKALYTGHIGDGKIFVYDVEDVVKVRTGESGYDALQGEDD
>NC_012778.1|WP_012738983.1|745063_745849_-|AraC-family-transcriptional-regulator
MKHMIQPFGIDMHKNVLTDTKAVKHMHFYEADKTNTILNISFIPSSTTEWIICYNDNNDISEFICIGCQNIFTTLSLKEFDHYFGIRFDNTGCYFNKGCDIKTYPVNITDNIFRYEPASQSYEMQLIKDFHNSSSFKDRIRLFKAFVTDCKTFCPVSENIEKLNRLIYSGAGTVAELSAESEYSVRHISRLYNEVYGIGAKDFIKMYRFQNVLAAIIADPDRDNSFFIEGAGYSDQAHFQREFRTFMGMTPKQYIKLIKNF
>NC_012778.1|WP_041688012.1|743854_745009_+|oxygen-independent-coproporphyrinogen-III-oxidase
MNKTYEKGIYIHIPFCVHKCIYCDFLSAPAGDAVKYAYTRALINEIRNTADRQVKDKITSIFFGGGTPSVLPDGCIADILSAVRDCFDISDDAEITMECNPGTVNESRLSEYRAAGVNRLSFGLQSADNNELKMLGRIHTFEQFEESFRLARDAGFNNINVDLMSAIPGQTEATLENTFDKVMALQPEHISVYSLILEEGTYLADNIDKFPPVPDEEEDRRMYHITKQILENAGYERYEISNYSRPGFECRHNLLYWNRGEYYGFGCSAAGFTGNERYSDIRDVREYIELNGDIGKLHENIEILTKEDAMEEFMFLGLRKVAGVDVKDFQNRFGVSINDVYAKETERNINKGLLVKRGDMLRLTEYGMDICNTVMSDFILTDGD
>NC_012778.1|WP_012738981.1|742047_743862_+|elongation-factor-4
MAGINQKNIRNFCIIAHIDHGKSTLADRIIEKTGLLTSREMQEQILDNMDLERERGITIKAQTVRTVYKASDGQEYIFNLIDTPGHVDFNYEVSRALAACDGAILVVDAAQGIEAQTLANVYLALDHDLDVFPVINKIDLPSAEPERVIEEIEDIIGIEAQDAPLISAKNGINIEEVLEQIVTKIPAPSGDASAPLSALIFDSLYDAYKGVIIFVRIKEGTVKKGTKIRMMATGAVEEVVEVGYFGAGRFIPCDELTAGMVGYITASIKNVRDTRVGDTVTDNDRPCEQPLPGYKKVNPMVYCGLYPADGAKYQDLRDALEKLQLNDAALQFEPETSIALGFGFRCGFLGLLHLEIIQERLEREYNLDLVTTAPGVIYKVHKTNGDVIDLTNPSNMPDPSEIDYMEEPMVSAEIMVTTEFVGPIMKLCQERRGIYNGMEYIEQTRALLKYDLPLNEIIYDFFDALKSRSRGYASFDYEMKGYERSKLVKLDILINKEEVDALSFIVFAGNAEERGRKMCEKLKEEIPRQQFEIPIQAAIGSKVIARETVKALRKDVLAKCYGGDISRKKKLLEKQKEGKKRMRQIGNVEIPQKAFMSVLKLDDE
>NC_012778.1|WP_012738980.1|741280_742048_+|N-acetylmuramoyl-L-alanine-amidase
MRGHKTFRIDKIFGLATLVCMLVLALMVYNDFFKSVSISTGTEKETQNETRNNNGIDKTEKESKPAKNITVCLDAAKGGKDMGLSSNGKKEKNITLDMALAVKEKLDIQGINVVLTRTSDTDVTDEARVNTCNKSSANIVVSLRMNSYNNDTSVSGAESYIHTTKPVEAAELSRKILASLEKSVGIKNRGVKAGTVADAKDNYYINAHSKCTSTIIDIGFITNASDLKKVTTDKDKTAQAIADGITDYLKQAGLY
>NC_012778.1|WP_041688518.1|740485_741226_+|RNA-polymerase-sporulation-sigma-factor-SigE
MVVKVAMADHFQFKVMPSIKNFCLLKQGDVHYIGGTDILPAPLGASEEQDAIEALGTASDAEAKHTLIEHNLRLVVYIAKKFDNTGVGVEDLISIGTIGLIKAINSYDKDKNIKLATYASRCIENEILMYLRRNSKIKAEVSIDEPLNVDWDGNELLLSDIIGTDEDIIYRDIETEVECKMLKRAINQLPERERIIVDLRFGLSSEDGEEKTQKEVADMLGISQSYISRLEKKIMRQLRKEMVKSC
>NC_012778.1|WP_012738978.1|739522_740443_+|sigma-E-processing-peptidase-SpoIIGA
MLYIIPPVTRKQIQNKEVITDTVIYADVLFGINFVANLCVLLITDWIFKFSARISRMIISATLGAAWAVMCVCIPLRFAVLGKFITYGPVTLIMAMIMLSGNEDFKHKTSKQLKLYMRKLLKAAAGMIFTALFAGGIMHWLKYTFAGYFIQNVILSDSELVIFLTVTVMAVVMVLKALKTIRITDGLKRHIVIGVAEREFEMDAIIDTGNSLVDYIGKRPVTVVERTYFNDILSDIDNLQKLGYHLIPYNSVGSSGGMMEIITADYIHIYEGENVVKREDAAIGMSPRQINKNGDYHALLGKDMIM
>NC_012778.1|WP_041688009.1|738264_739434_+|cell-division-protein-FtsZ
MLEIMTNDQESSAKIIVVGVGGAGNNAVNRMIDENISGVEFIGINTDSQALTLCKAPTAIQIGEKLTKGLGAGAQPEIGEKAAEENVEELTQAIKGADMVFVTCGMGGGTGTGAAPVVAKISKDMGILTVGVVTKPFKFEARTRMANAESGIEKLKENVDTLIVIPNDKLLEIVDRRTTMPEALKKADEVLQQAVQGITDLINVPGLINLDFADVKTVMVDKGVAHIGIGTATGDDKAIEAVKQAVTSPLLETTIEGASHVIINISGDISLIEANEAASYVQELAGDNANIIFGAMYDESVTDQATITVIATGLEDGNVNKAMAGFAGMAQATRPTVNVKPQYTYTQSARTSSVSNDAPLPGLKQPSPVTPQVKDRGITIPTFLQKNKK
>NC_012778.1|WP_012738976.1|737429_738185_+|hypothetical-protein
MGSKNRNSVNQKKRRGRKRKKVLIIFAVIATVAGTLFGVTYKVFEADTIEFVGSTHYSDEELKKYIFGGDYVNLLYFKIFGQKDTKIPFIQKYDVETDWPDRLYVTVYEKAIVGYVRYMGCNMYFDKDGIVVESSTDLYENVPEIDGLNFNSIVINTKLDAGNSEIYNTILDLTQSFDKYDINVDKVYFDSSYNITLYMGDVKVSLGSSKDFTDRLFELKQLSPKFGTLKGTLYLDDYNGDESSIIFKREK
>NC_012778.1|WP_012738987.1|752257_752992_+|hypothetical-protein
MNTNIINKKKLITSIIFKAISLIASVYGLVFTIDSIKSFTFFTTLSNVALDIVLAVFIVLDVILLTKGKDYKNNGLYILKFLMTLSITLTCLVYMIILGPTSEDGLIGAYLNKYAGSLGVHLIGPVFAIADFLVFDKEFSAKKIYAIYAVIPPLCYVAFVYILAALGVRWYDTMTAPYNFLNYAAPAGWFGWDLSQMGSESLGIGVVYMIVVLLLIFIGIGLLYLAINGAGREAKAQKAELVSE
>NC_012778.1|WP_041688016.1|753202_754939_+|ABC-transporter-ATP-binding-protein
MKENLKKLAKYYKPYLGTFILDMILAMMSAAVALVIPLVVRFITSKVAYMSANEALSRIMIIVAVLFVLVLIQWGCNYYISNYGHVMGAKIEYDMRAEIFNHYQKLSYSFYDDQKVGQLLSRITSDLFDITELLHHGPENITISLIKIIGALCILSSIDLRLTIAAFVLIPFMLVFAYVLNKRMKRAFKRNRVRIGEINAQIEDNLSGIRVVKSFANEDIECEKFKKGNDLFLESKRDSYHYMGMYNAGLTAFTTMINVIVIAAGGIGIAKGWVNITDFVTFLLYINIFTEPVKVLIDFTEQFQNGYSGYERFLEILSVEPEIADKPDAKELTDVKGAITFENVSFRYKDGVDEVLSGVNLSVRPGEYVALAGPSGVGKTTLCSLIPRFYEVTGGSIKIDGTDIKDVTLKSLRDHIGVVQQDVYLFMGTIKENIRYGKPDATDEEVIQAAKLANAHDFIMSFENGYDTDIGQRGVKLSGGQKQRLSIARVFLKNPPILIFDEATSALDNESEQIVQESLEKLAKNRTTFVIAHRLTTIENAEEILMLTDEGIKERGTHEELMKLDGEYARMVKIHSRT
>NC_012778.1|WP_041688522.1|755006_755972_+|porphobilinogen-synthase
MDRTRRLRMNATLRDMVRENHVRVDELIYPVFVTEENDVIQEVPSMPGICQYSLDHVLEEIGRAVEVGIKGILLFGIPVHKDEVGSEAYDEKGVVCRAIRLIKDAYPELVIMADVCLCEYTSHGHCGLVKDGVILNDETLPLLAKASVAYAKAGADIIAPSDMMDKRVEAIRNALDEAGLVNIPICSYSAKFASGYYGPFRDAAHSAPEFGDRKTYQMDPANGKEALREVEEDILEGADMIIAKPALGYMDVMKEIALNFNIPIVAYNVSGEYAMVKAAAMNGWIDEKKIVMENMTGFKRAGAKMIITYHAIDVAKWLKEE
>NC_012778.1|WP_012738990.1|756013_757288_+|glutamate-1-semialdehyde-2,1-aminomutase
MNEEMSNDLYERAVKHMPGGVNSPVRAYKAVDRVPRFIASAKGDRITDVDGNEMIDYICSWGPGILGHAHDRVIAKVKEAAEAGLTYGAPTKREVEMAELIYELIPTMEVSRLVSSGTEAVMSAIRVARGYTRRDKIIKFRGCYHGHSDGLLVKAGSAALTTSVPDSAGVPADYTKNTLVAEYNDCDSVKELFDNNKDEIAAVIVEPVAANMGVVLPRHGFLEFLRDITKENGSLLIFDEVITGFRLSIGGAQEYFNIKPDLTTLGKIVGGGMPVGAYGGRADIMRMVSPDGPVYQAGTLSGNPIATAAGLETLRILRDNKDIYDRLETKTKRIADSVRKCGAGRVSVNQIGSLMSIFFTPDAVEDYDSAVKSDTKKYAEYFGHMLDNGIYIAPSQFEAMFVSDAHTNEDINRTIEVMEEFFRK
>NC_012778.1|WP_012738991.1|757312_758530_+|glutamyl-tRNA-reductase
MQLGYVGINYKNTDLSVRDKITFTDSGIADFMQQAEEAGVKQCMCLSTCNRCEVFYLYEDETFVQVMSDLFNDYFGLTDTKLAGVKCGEEALVYLFCIAAGLESMVLGEDQILGQLKDAADLSRTLGHSGKELNYIVREAVSCAKRIKTEYKVSEKPVSVCYVGIQELDRVCGISGKHALVIGSGKTAALAIRYLAEYGADVTVCSRTYQHAKALLKEFSQIEVIAYDKKTEALKSSDIVVSATSSPHLVIKCAELSGGKKMTLLDLAAPRDIEKSAGDIFGVTLIDLDRIGGIVKSNQNERAHLLKESQCVIDEYIAETKKWLTSSRMDTTIQSLGKKCDEIVQDSYDYLNRKIDLSDHDRVILKKILKSSLHRLLKEPIEELKNVEENEQQQYKDMVERLFGL
>NC_012778.1|WP_012738992.1|758538_759426_+|hydroxymethylbilane-synthase
MHYRIGTRGSKLALVQSEYVKRRMEEAYPEDTFELVIIKTTGDKVTDKPLAAIGTKGFFVKEIEEALLSGSIDMAVHSMKDMPAECAAGLTFAKAWKREDCRDVLILKTAGSFSELPSGAVIGTGSLRRACQLAMLRPDIQFTAIRGNVDTRINKLMDDSYGLDGIVLAAAGLNRLGRSSEITEYLDPEVVIPAPAQGVLAIETAEVNTELLDKINALSDDNSDREAVAERTFLRLTGGGCHAPVGAHCVTKDNGDLRMVVLFGNDDCSRILRIEVTGTDSEAVGHEAARMLGLE
>NC_012778.1|WP_012738993.1|759429_760260_+|uroporphyrinogen-III-synthase
MGKYIYTYIENGQMYDKSPSFAELLAKEGLSCEKIVTGRIGYIRVENLLEKIKDAQWLVFTSKNAVAGFAYNMGKMACEGEPDCDGVLNGDSVEAFGVRSGFPDGIKIAVVGNKTKEALRTACGFEADFVSYKSTGLELGRSLMNIAAGKIVYLCAEVTSGSLEEAMKEYENLIKIPVYRNEYVDTYAEYEMKDISDVSGIAVTSGSSGERIKWLIDRLGESGEVPVFSIGPACSRKLFEAGVKKNRIIEACEHSYSGLVEAIKKSAGKPEAGIGR
>NC_012778.1|WP_041688018.1|760773_761706_+|cysteine-synthase-A
MGKIYKSAADLIGNTPLVEVGHIEEKFGLKARVLVKLEYFNATGSVKDRVAKAMIEDAEKKGILKPGATIIEPTSGNTGIGLAAIATAKGYRTIIVLPETMSVERRNIIKAYGAEIVLTPGYKGMTGAIAKAEELKNEIEGSMIAGQFVNPANPDAHRRTTGPEIWNDTDGEVDAFVAGVGTGGTITGVGEYLKSKNDKIEIIAVEPATSPVLSQGKPGPHKIQGIGAGFVPEILNTKIYDSVVPIDNDDAFEYARLISHTEGILVGISAGAALYAAIEWAKKPENEGKTIVALLPDSGDRYYSTSLFEN
>NC_012778.1|WP_041688020.1|761845_763261_+|spore-germination-protein
MTDFTTNIDMNVRMMNEKLRVDRNFDILQRDVLIGGKRTHFYFIDGFVQEETIEKLVQFFYSLKESDIKDIDTFLEVGMPYTEIEKNGHYDEVEKAFLSGQTVMIIDGFDECILIDCRTYPMRSVTEPYKDKVLRGSRDGFVETLVCNAALLRRRIRDSRFSMEMYTVGERSRTDVAVCYIDDKVDKKLLERIENLISSIEVEALTMNIESLAECMFKGKWINPFPKYKYSERPDTAAAALFDGNIVIMVDTSPAVMIIPTNVFDIIEEADDFNFSPMIGTYIRLSRFFFTLLTVFLTPVWLLLESNPQWVPEWLKFITISENITVPVILQLFILELAVDGLKLAAVNTPGMLSTPLSILAGIVVGEYAVESGWFNSESLLYMAVVTVGTYSQASFEMGYALKFIRIVNLILVQFFGRIGLLAGAIFAIVLVCFNRTISGKSYIYPVIPFNSQMFKRKILRVRLPHKIKNN
>NC_012778.1|WP_012738998.1|763402_763717_+|helix-turn-helix-transcriptional-regulator
MISDYEEVVIRFKAYRISYPLTQKELSDKSGVSLRSITRFESGEDISLVNFMKLMNAMELMNNFVNVIPDMNNRPSSYLKNVKTRQRASAKRKADTGFKWGEDE

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Crispr_ID: NC_012778_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012778_2

1467680-1468217

TypeV-A,TypeI-A

V-A

Consensus_repeat	Method
ATCTACAAAGTAGAAATTATTTAAGGTTATTCAAAC	CRISPRCasFinder
ATCTACAAAGTAGAAATTATTTAAGGTTATTCAAAC	CRT
ATCTACAAAGTAGAAATTATTTAAGGTTATTCAAAC	PILER-CR

8 spacers

cas2,cas1,cas12a

The CRISPR arrays of NC_012778_2

>merge|NC_012778|2|1467680-1468217|CRISPRCasFinder,CRT,PILER-CR
ATCTACAAAGTAGAAATTATTTAAGATTATTCAAACTTATCTGTGCTAGGAAATGCCATATCCATCTACAAAGTAGAAATTATTTAAGGTTATTCAAACATGGCAGAAGATACGGCCAGAGCAATATCTACAAAGTAGAAATTATTTAAGGCTATTCAAACTAACACATATTGTATTGATCATGGAAATCTACAAAGTAGAAATTATTTAAGGTTATTCAAACAAATTATAAAGTAACAACACAAGTAAAATCTACAAAGTAGAAATTATTTAAGGTTATTCAAACATAAACCAATGAGAAAATTACTTGGATATATCTACAAAGTAGAAATTATTTAAGGTTATTCAAACCTGTAGCAAGGGCAGTAACCAATTACTATCTACAAAGTAGAAATTATTTAAGGTTATTCAAACACAACTATTATATAATTATCGGGTGATCTACAAAGTAGAAATTATTTAAGGTTATTCAAACTGAGCCAGTACCAGACACTAAGTATCAATCTACAAAGTAGAAATTATTTAAGGTTATTCAAAC

>NC_012778|2|2|1467680-1468217|CRISPRCasFinder
ATCTACAAAGTAGAAATTATTTAAGATTATTCAAAC	TTATCTGTGCTAGGAAATGCCATATCC
ATCTACAAAGTAGAAATTATTTAAGGTTATTCAAAC	ATGGCAGAAGATACGGCCAGAGCAAT
ATCTACAAAGTAGAAATTATTTAAGGCTATTCAAAC	TAACACATATTGTATTGATCATGGAA
ATCTACAAAGTAGAAATTATTTAAGGTTATTCAAAC	AAATTATAAAGTAACAACACAAGTAAA
ATCTACAAAGTAGAAATTATTTAAGGTTATTCAAAC	ATAAACCAATGAGAAAATTACTTGGATAT
ATCTACAAAGTAGAAATTATTTAAGGTTATTCAAAC	CTGTAGCAAGGGCAGTAACCAATTACT
ATCTACAAAGTAGAAATTATTTAAGGTTATTCAAAC	ACAACTATTATATAATTATCGGGTG
ATCTACAAAGTAGAAATTATTTAAGGTTATTCAAAC	TGAGCCAGTACCAGACACTAAGTATCA
ATCTACAAAGTAGAAATTATTTAAGGTTATTCAAAC

>NC_012778|2|1|1467680-1468217|CRT
ATCTACAAAGTAGAAATTATTTAAGATTATTCAAAC	TTATCTGTGCTAGGAAATGCCATATCC
ATCTACAAAGTAGAAATTATTTAAGGTTATTCAAAC	ATGGCAGAAGATACGGCCAGAGCAAT
ATCTACAAAGTAGAAATTATTTAAGGCTATTCAAAC	TAACACATATTGTATTGATCATGGAA
ATCTACAAAGTAGAAATTATTTAAGGTTATTCAAAC	AAATTATAAAGTAACAACACAAGTAAA
ATCTACAAAGTAGAAATTATTTAAGGTTATTCAAAC	ATAAACCAATGAGAAAATTACTTGGATAT
ATCTACAAAGTAGAAATTATTTAAGGTTATTCAAAC	CTGTAGCAAGGGCAGTAACCAATTACT
ATCTACAAAGTAGAAATTATTTAAGGTTATTCAAAC	ACAACTATTATATAATTATCGGGTG
ATCTACAAAGTAGAAATTATTTAAGGTTATTCAAAC	TGAGCCAGTACCAGACACTAAGTATCA
ATCTACAAAGTAGAAATTATTTAAGGTTATTCAAAC

>NC_012778|2|1|1467743-1468217|PILER-CR
ATCTACAAAGTAGAAATTATTTAAGGTTATTCAAAC	ATGGCAGAAGATACGGCCAGAGCAAT
ATCTACAAAGTAGAAATTATTTAAGGCTATTCAAAC	TAACACATATTGTATTGATCATGGAA
ATCTACAAAGTAGAAATTATTTAAGGTTATTCAAAC	AAATTATAAAGTAACAACACAAGTAAA
ATCTACAAAGTAGAAATTATTTAAGGTTATTCAAAC	ATAAACCAATGAGAAAATTACTTGGATAT
ATCTACAAAGTAGAAATTATTTAAGGTTATTCAAAC	CTGTAGCAAGGGCAGTAACCAATTACT
ATCTACAAAGTAGAAATTATTTAAGGTTATTCAAAC	ACAACTATTATATAATTATCGGGTG
ATCTACAAAGTAGAAATTATTTAAGGTTATTCAAAC	TGAGCCAGTACCAGACACTAAGTATCA
ATCTACAAAGTAGAAATTATTTAAGGTTATTCAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_012778.1\|WP_041688171.1\|1468548_1468797_-\|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|213942
NC_012778.1\|WP_012739644.1\|1466230_1466998_-\|Uma2-family-endonuclease	unknown	unknown	gnl\|CDD\|99749
NC_012778.1\|WP_012739636.1\|1451475_1451712_-\|HPr-family-phosphocarrier-protein	unknown	unknown	gnl\|CDD\|238217
NC_012778.1\|WP_012739652.1\|1477315_1478575_-\|saccharopine-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|224662
NC_012778.1\|WP_012739637.1\|1451773_1452931_-\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NC_012778.1\|WP_041688674.1\|1463599_1466209_-\|NYN-domain-containing-protein	unknown	unknown	gnl\|CDD\|223556
NC_012778.1\|WP_012739647.1\|1468899_1472748_-\|type-V-CRISPR-associated-protein-Cas12a/Cpf1	cas12a	cas12a_cpf1_CAS-V-A	gnl\|CDD\|275131
NC_012778.1\|WP_041688167.1\|1450448_1451450_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|223787
NC_012778.1\|WP_012739649.1\|1474072_1474945_-\|N-carbamoylputrescine-amidase	unknown	unknown	gnl\|CDD\|274553
NC_012778.1\|WP_012739654.1\|1479476_1480931_-\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|224893
NC_012778.1\|WP_012739642.1\|1462133_1463564_-\|carbohydrate-esterase-family-12-protein	unknown	unknown	gnl\|CDD\|238859
NC_012778.1\|WP_012739648.1\|1473048_1474014_+\|hypothetical-protein	unknown	unknown	unknown
NC_012778.1\|WP_012739638.1\|1453049_1454534_-\|glutamate-synthase-subunit-beta	unknown	unknown	gnl\|CDD\|237213
NC_012778.1\|WP_041688670.1\|1454595_1459134_-\|glutamate-synthase-large-subunit	unknown	unknown	gnl\|CDD\|236968
NC_012778.1\|WP_012739651.1\|1476070_1477300_-\|carboxynorspermidine-decarboxylase	unknown	unknown	gnl\|CDD\|143502
NC_012778.1\|WP_012739650.1\|1474946_1476068_-\|agmatine-deiminase	unknown	unknown	gnl\|CDD\|184135
NC_012778.1\|WP_012739641.1\|1460415_1462029_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|224157
NC_012778.1\|WP_041688169.1\|1459501_1460413_-\|diacylglycerol-kinase-family-lipid-kinase	unknown	unknown	gnl\|CDD\|224513
NC_012778.1\|WP_081458297.1\|1468340_1468571_-\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NC_012778.1\|WP_012739653.1\|1478571_1479429_-\|polyamine-aminopropyltransferase	unknown	unknown	gnl\|CDD\|234843

Protein	Function_ID	Function_description	E-value
NC_012778.1\|WP_041688171.1\|1468548_1468797_-\|CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|213942	TIGR04329, hypothetical_protein_SbacW_07302_partial, CRISPR-associated endonuclease Cas1, subtype PREFRAN. Members of this family are the Cas1 endonuclease of a novel CRISPR subtype, PREFRAN, found in Prevotella bryantii B14, Prevotella disiens FB035-09AN, Francisella tularensis subsp. novicida, Francisella philomiragia, Butyrivibrio proteoclasticus B316, Helcococcus kunzii ATCC 51366, etc.	8.44634e-30
NC_012778.1\|WP_012739644.1\|1466230_1466998_-\|Uma2-family-endonuclease	gnl\|CDD\|99749	cd06260, DUF820, Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of nucleases.	1.32932e-34
NC_012778.1\|WP_012739636.1\|1451475_1451712_-\|HPr-family-phosphocarrier-protein	gnl\|CDD\|238217	cd00367, PTS-HPr_like, Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate is transferred to HPr by enzyme I (EI). Phospho-HPr then transfers the phosphoryl group to one of several sugar-specific phosphoprotein intermediates. The conserved histidine in the N-terminus of HPr serves as an acceptor for the phosphoryl group of EI. In addition to the phosphotransferase proteins HPr and E1, this family also includes the closely related Carbon Catabolite Repressor (CCR) proteins which use the same phosphorylation mechanism and interact with transcriptional regulators to control expression of genes coding for utilization of less favored carbon sources.	1.64575e-07
NC_012778.1\|WP_012739652.1\|1477315_1478575_-\|saccharopine-dehydrogenase-family-protein	gnl\|CDD\|224662	COG1748, LYS9, Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism].	3.7157e-159
NC_012778.1\|WP_012739637.1\|1451773_1452931_-\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	2.97999e-54
NC_012778.1\|WP_041688674.1\|1463599_1466209_-\|NYN-domain-containing-protein	gnl\|CDD\|223556	COG0480, FusA, Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis].	1.63946e-123
NC_012778.1\|WP_012739647.1\|1468899_1472748_-\|type-V-CRISPR-associated-protein-Cas12a/Cpf1	gnl\|CDD\|275131	TIGR04330, conserved_hypothetical_protein, CRISPR-associated protein Cpf1, subtype PREFRAN. This family is the long protein of a novel CRISPR subtype, PREFRAN, which is most common in Prevotella and Francisella, although widely distributed. The PREFRAN type has Cas1, Cas2, and Cas4, but lacks the helicase Cas3 and endonuclease Cas3-HD.	0
NC_012778.1\|WP_041688167.1\|1450448_1451450_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|223787	COG0715, TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism].	1.38406e-25
NC_012778.1\|WP_012739649.1\|1474072_1474945_-\|N-carbamoylputrescine-amidase	gnl\|CDD\|274553	TIGR03381, putative_carbon-nitrogen_hydrolase, N-carbamoylputrescine amidase. Members of this family are N-carbamoylputrescine amidase (3.5.1.53). Bacterial genes are designated AguB. The AguAB pathway replaces SpeB for conversion of agmatine to putrescine in two steps rather than one. [Central intermediary metabolism, Polyamine biosynthesis].	1.1253e-174
NC_012778.1\|WP_012739654.1\|1479476_1480931_-\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|224893	COG1982, LdcC, Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism].	1.73552e-149
NC_012778.1\|WP_012739642.1\|1462133_1463564_-\|carbohydrate-esterase-family-12-protein	gnl\|CDD\|238859	cd01821, Rhamnogalacturan_acetylesterase_like, Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are highly branched regions in pectic polysaccharides, consisting of repeating -(1,2)-L-Rha-(1,4)-D-GalUA disaccharide units, with many rhamnose residues substituted by neutral oligosaccharides such as arabinans, galactans and arabinogalactans. Extracellular enzymes participating in the degradation of plant cell wall polymers, such as Rhamnogalacturonan acetylesterase, would typically be found in saprophytic and plant pathogenic fungi and bacteria.	6.49154e-47
NC_012778.1\|WP_012739638.1\|1453049_1454534_-\|glutamate-synthase-subunit-beta	gnl\|CDD\|237213	PRK12810, gltD, glutamate synthase subunit beta; Reviewed.	0
NC_012778.1\|WP_041688670.1\|1454595_1459134_-\|glutamate-synthase-large-subunit	gnl\|CDD\|236968	PRK11750, gltB, glutamate synthase subunit alpha; Provisional.	0
NC_012778.1\|WP_012739651.1\|1476070_1477300_-\|carboxynorspermidine-decarboxylase	gnl\|CDD\|143502	cd06829, PLPDE_III_CANSDC, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase. Carboxynorspermidine decarboxylase (CANSDC) catalyzes the decarboxylation of carboxynorspermidine, the last step in the biosynthesis of norspermidine. It is homologous to eukaryotic ornithine decarboxylase (ODC) and diaminopimelate decarboxylase (DapDC), which are fold type III PLP-dependent enzymes that contain an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain, similar to bacterial alanine racemases. Based on this similarity, CANSDC may require homodimer formation and the presence of the PLP cofactor for its catalytic activity.	0
NC_012778.1\|WP_012739650.1\|1474946_1476068_-\|agmatine-deiminase	gnl\|CDD\|184135	PRK13551, PRK13551, agmatine deiminase; Provisional.	0
NC_012778.1\|WP_012739641.1\|1460415_1462029_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|224157	COG1236, YSH1, Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis].	6.19318e-105
NC_012778.1\|WP_041688169.1\|1459501_1460413_-\|diacylglycerol-kinase-family-lipid-kinase	gnl\|CDD\|224513	COG1597, LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only].	1.0454e-54
NC_012778.1\|WP_081458297.1\|1468340_1468571_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	1.64348e-08
NC_012778.1\|WP_012739653.1\|1478571_1479429_-\|polyamine-aminopropyltransferase	gnl\|CDD\|234843	PRK00811, PRK00811, polyamine aminopropyltransferase.	1.80784e-151

>NC_012778.1|WP_012739644.1|1466230_1466998_-|Uma2-family-endonuclease
MTINEMKEKKKEKGYSYAKIAELSGVPLGTVQKIFSGETESPRYDTLTALEQVFNEQLEVREPGGLYKARKNGEYTIDDYRALPDEQRVELIDGYFYDMASPTFGHQSIGGEIHRQIANYIMELGGNCRPFIAPVDVQLDCDERTMVQPDVGIVCDISKIKRFGIYGAPDFVVEVVSSSTKKKDYALKLSKYMEAGVREYWILDFAQEKVLVYFFESDVYPVIYGFDKPVPVNIYNGELKIDFTNIARWLKEGME
>NC_012778.1|WP_041688674.1|1463599_1466209_-|NYN-domain-containing-protein
MAHSNPITIGMLAHVDAGKTTLSEAILYSAGSIRKLGRVDNQDTFLDTGDMERARGITIFSKQAAYNYNGSSYTLLDTPGHVDFSAETERTLWVLDAAVLVISGMDGVQGHTETLWSLLKRLGIPVFIFVNKMDQQGTNRARIMEQLKNRLSESCVDFNNIDYEEVAMCHEEALEQFLESAHVDDALMSRMIMERKMFPVYFGSALRMNGVEELINGIDTYVSCPDYGEEFSAKVYKITRDDRGERLTHLKVCGGSLKSKMLIGNEKVNQIRVYAGDKFTSINEAVAGTVCAVTGLSETKAGQFIGAGGEDNIPVLEPVLNYKLNLPAGTDPVALLSKLRTLEEEEPELHVEWDENFKEIHVSVMGPVLIEVLTNIIRTRFGVDVTFGEGSIVYKETIKNKAYGIGHFEPLRHYAEVHLLLEPGEPGSGMRYECHCSEDILDKNWQRLVYTHLCEKMHRGVLTGSELTDMKITLVAGRAHPKHTEGGDFRQATYRAVRQGLMQAESVLLEPFYVFSLEVKRDYVGRAMTDFERMGAAFNMQEADGDNVVITGEGPVSVIGNYQAEVNAYTKGTGRLALKMAGYRPCHNTEEVIEKFGYEPERDTRNPVDSVFCAGGSGYVVPWNEVREHAHVEIAVTDSGVAGGQSDREVKLTAKQASRTVSDEWIGTDEVDRILNETYFSNSRGDNERRKLSKRKADTAVGRYVTGGNANVKNHPKAPEYNPAKKSFLLVDGYNIIHAFKELSELAQVNLDSARGRLLDILCNYQAMKGCELIAVFDAYRVPGHDEEFIDFHNIHVVFTKTAETADHYIEKFAHENGKKYNVTVATSDGVEQVIIRGQGCLLISAREFEKEIAAMEEHLRENYLNKTY
>NC_012778.1|WP_012739642.1|1462133_1463564_-|carbohydrate-esterase-family-12-protein
MSTLWVVGDSTLSSFDDKYYYPRYGYGTKLGCYLNSMVQVNNLALSGRSSLSFTKEENYKELLAGMKAGDFLIIGFGHNDEKTETGRYTSPIGGRDKKGTFAASLYDNYIKPALDVSCTPILCTPIVRRTATGEWTKQELHITDDAAQFKGGDYSQAVRDLARDLGIVCVDMTEKTKALYDELGPEETIYLHAWPSNKEVSVDNTHTNIWGGRVNAFLVMQELEKAGISGLSENIVNIRADEPLPDKNRYLEKNASYKPVEFSDELADSKNFKDAYGFKGTVFGDVTTLPTESDNYILEEVPGGIHIAVKNNDGKISAVTDGIAMYYKKIPVNVNFTLKAKMTINDYFYNNQVSFGLMVRDDMYIDKKMPDVLGDYVAAAPLNLTYKDQAWSCFARKNSELMQGSVTGRELKPGDTVEVCIKSNPDGYAVKLGDGEFLTGGFDFKLTAVDPKHVYAGFFVSRNADVTFTDIEYTEN
>NC_012778.1|WP_012739641.1|1460415_1462029_-|MBL-fold-metallo-hydrolase
MKLTFLGADHEVTGSCHFLQAAGLNILVDCGMEQGNDVYENQELPVVASDVDCILLTHAHIDHSGLIPLMYVNGFRGQVYSTSATAQLCEIMLRDSAHIQMFEAEWRNRKAARSGGKLKEFVPLYDMDAAVNVCKQFVGCEYDRVYDIAEGIKIRFTDVGHLLGSASIEVWATEKTENGDVTEKIVFSGDIGNINKPIIKDPKHVTDADYVVMESTYGNRSHGGTPNYVEDLTNIFKRTFERGGNVVIPSFAVGRTQELLYIIRKIKEDNLVGRDFDVYMDSPLAIEATNIFIKNVESCFDDEAVELVRKGINPLSFPGLKYATTGDESKQINFDPNPKVIISSSGMCEAGRIRHHLKHNLWRPECTIVFVGYQAVGTTGRIIVDGAEEIKLFGEPIQIKAEIVQLKGSSGHADKDGLLCWINAFDTKPKKVFVVHGEDSVCDEFTECLKEEYGYDAMAPYTGGSYDFIADRVISEGVKERKTRRTTSTQRGKTVFDRLVAAGKRLMTVITHNEGGTNKDLAKFTDQINALCDKWDR
>NC_012778.1|WP_041688169.1|1459501_1460413_-|diacylglycerol-kinase-family-lipid-kinase
MMKMLFVFNPNSGKAQIKNQLMKIIQVFSKAGYEITVYPTKAPLDGYQHILDNEGRYDVITCSGGDGTLNETVAAVLKYKGEKPPIGYIPSGTTNDFAASLGIPRNMTKAAVNIAKGKRFPCDVGIVNGERSFNYVAAFGAFTRVSYGTPQNLKNILGHQAYVIEAVRSLSTIKPQYMRVYSEEMNVEGNFVYGMISNTDSVGGIKNLTGNDVNLQDGLFEVTMIRELNNPIAVQSLINAFITKDLSKCDWVCTWKTESVRFESPQPVSWTLDGEYGGEHTEIQFSVKEKAVDFLIGGVPVNN
>NC_012778.1|WP_041688670.1|1454595_1459134_-|glutamate-synthase-large-subunit
MENEIKQPGLYRSELEHDACGIGAIVSINGIKTHQTVSDALSIVENLEHRAGKDAEGKTGDGVGILLQISHKFFKKAVKPLGIELGDERDYGVGMFFFPQDELARNRAKKMFEIIVEKEGLEFLGWRDVPTFPNVLGKKAVDCMPYIMQGFVKRPANAAKGIEFDRRLYVARRVFEQTAEDTTYVCSLSSRTIVYKGMFLVGQLRQFFGDLENPDYESAIALVHSRFSTNTNPSWERAHPNRFMVHNGEINTIKGNADRMLAREETMTSPYLEDEMSKITPVVNTNGSDSAMLDNTLEFFVMNGMPLPLAVMITIPEPWINNGAMAQEKKDFYQYYATMMEPWDGPASIAFTDGDYFGAVLDRNGLRPSRYYITNDGYLILSSEVGALPIPESRIKLKDRLRPGKMLLIDTVKGELIEDDKLKEEYATKNPYGEWLDSNLIQLKDLKIPNKKVPVHTKEERARLQKAFGYTYEDFKTSILPMALNGTEQTGAMGIDTPLAVLSNKHQPLFNYFKQLFAQVTNPPIDSIREKVVTSTTVYLGTEGNILEEKAENCKQLRINDPILTNTDLLKIKNMNVEGFKVETIPIIYYKNTSLERAIDHLFVEVDRAHREGANIIILSDRGVDENHVAIPSLLAVAALQQYLVQTKKRTSMAVILESGEPRDVHHFATLLGYGASAINPYLAQESIQELIDLNMLDKDYYAAVDDYNKAIITGIVKIAAKMGISTIQSYQGAKIFEAIGINSDVIDKYFKGTVSRIEGVSLNDIQEDVETLHSKAFDPLGLSTDTTLDSSGAHKMRSGKEEHLYNPQTIHLLQLATRTGDYKTFKEYTALVNKEEGVKNLRGLMNIKFPKKGISIDEVESVDSIVRRFKTGAMSYGSISREAHETMAIAMNMLHGKSNSGEGGEDIDRLKVGPDGLNRCSAIKQVASGRFGVTSRYLVSAQEIQIKMAQGAKPGEGGHLPGKKVYPWIAKTRLSTPGVALISPPPHHDIYSIEDLAQLIYDLKNANKNARISVKLVSEAGVGTVASGVAKAGAQVILISGYDGGTGAAPRSSIHNAGLPWELGLAEAHQTLTMNGLRNKVIIETDGKLMSGRDVAIAAMLGAEEFGFATAPLVTMGCVMMRVCNLDTCPVGVATQNPELRKRFTGKPEYVVNFMRFIAQELREIMADLGIKTLDELVGRTDLLEQKNVAKSGRSAEIDLSQILDNPYVKQTKIHYDKKNVFDFELEKTVDEKILLKKFESAMETGSKRSLEIDVANTDRTLGTLLGAEITRRFDDKLDDDTYTVKCNGAGGQSFGAFIPKGLTLELVGDSNDYFGKGLSGGKLIVYPPTGSTYKEDENIIIGNVALYGATSGKAFINGVAGERFCVRNSGATAVVEGTGDHGCEYMTGGTVVVLGKTGKNFAAGMSGGIAYVLDEDTSLYKRVNKQLVSMEAVSNKYDVLELKQLITEHVAYTNSKKGKEILDNFGEYLPKFKKIMPHDYKKMLNMIVQMEEKGLSSEQAQIEAFYAATK
>NC_012778.1|WP_012739638.1|1453049_1454534_-|glutamate-synthase-subunit-beta
MGKPTGFLDYERVEATAVSPKERIKNFNEFHTPLSEDEQRKQSSRCMDCGVPFCQSGMTIKGMTSGCPLNNLIPEWNDLLYTGNWEQAYHRLHKTSNFPEFTSRVCPALCEKACTCGLNGKAVCTKENEMAIIEHAYAKGYAKANPPKVRTKKRIAVVGSGPAGLAVADQLNQRGHSVTVYERADRIGGLLRYGIPNMKLEKHIIDRKLDIMKEEGIEFVTNANVGENIKAKKLMADYDAVVLACGAANPRDINAPGRDANGIYFAVDFLTATTKSLLDSGLKDGRYISAKDKNVIVIGGGDTGNDCVGTCIRHGCKSVTQLEMMPKAPDERAENNPWPQWPLVCKTDYGQEEAIAVFGHDPRIYTTTVKEFKKDKKGNLTSVVTVKLESKTDEKTGRRMMVPVEGTEAELPCELVLIAAGFLGSQKYVTDAFGVELTERTNVKTAADGFETSVPGVFTAGDMHTGQSLVVKAIRQGRDCARAVDYYLMGYTNL
>NC_012778.1|WP_012739637.1|1451773_1452931_-|GGDEF-domain-containing-protein
MGRVDCMGAKGKMIELNRGVSDINMKRAYLSSVLLSVAVPVSVIAACIGNWSGVFARNTYIVVAGLMEVFQLLFMFVLRKQYSLDEFDRFHAIYTAYFYVTFVYLMFGAVCDIAQSGSILFYLAACVYIVFIPAFTKAECIGILMFQTVVVILLSIVSSMDLRMFFDVCIIQAATILLVAYQHNLAVQRVRVNMQLKRKKDYSEHDALTGLYNRRGLDARIKAIWPFCERNRLSVAMIAVDVDYFKKYNDTFGHPKGDECLKTVAGILKNSAQRSTDVVTRTGGEEFIVFVQDMDEESLISLAMKIRNNLDQKHIEHAYYGVSKYVTVSMGIAGFVPAYNNDFKKLYQEADNALYLAKKNGRNCIVYDGKVYGSIMNGASRVAST
>NC_012778.1|WP_012739636.1|1451475_1451712_-|HPr-family-phosphocarrier-protein
MLTVTILLDSVEKVQRFVSTISKYSCGFDVESGYSCVDGKSLVGLFSLDISKPLQLTINDGEGEIEDVLRDIQEFMEY
>NC_012778.1|WP_041688167.1|1450448_1451450_-|ABC-transporter-substrate-binding-protein
MKKLLAVMLSVIMVFSFAACAGKSVNNEGESQTEETTTIRIGAMAGPTAMGMVKLRKDSENGNTKNTYAFEDFATDASAFVTPLATGEIDIAAVPSNLAANIYNKTEGKVQVVAVNTLGVLNLVERGNTVNSISDLKGKTIYATGMGAVPEYTIRYILSGNGLDADKDVDIVWCSDTTEALSKLKSEDGAIAVLPQPFVTAASAQISGLRVVMDLNEAWEKINNNSKIVTGVIVVRKEFAEKYPEQLKKFIDEYNESVAYTSSNIDETAQLIAEYGIVASEAIANKALPKCHIVCYINNNMRSALEGFLQVLYDQNPKSVGGSMPKDDFYYEY
>NC_012778.1|WP_081458297.1|1468340_1468571_-|CRISPR-associated-endonuclease-Cas2
MFAKYLSKFGHRIQYSVFEIDNSTRILDNIISDLKNKYEKRFSQEDSVMIFKLSSSCEVLRFGYAKNDEKDFIIIT
>NC_012778.1|WP_041688171.1|1468548_1468797_-|CRISPR-associated-endonuclease-Cas1
MLFNIVDAILQVYGFDTYYGVFHKCFYMRKSLVCDLMEPIRPVVDYQVRKSINLGQCKENDFEVINNRWCLKFKNNFCKIFV
>NC_012778.1|WP_012739647.1|1468899_1472748_-|type-V-CRISPR-associated-protein-Cas12a/Cpf1
MNGNRSIVYREFVGVIPVAKTLRNELRPVGHTQEHIIQNGLIQEDELRQEKSTELKNIMDDYYREYIDKSLSGVTDLDFTLLFELMNLVQSSPSKDNKKALEKEQSKMREQICTHLQSDSNYKNIFNAKLLKEILPDFIKNYNQYDVKDKAGKLETLALFNGFSTYFTDFFEKRKNVFTKEAVSTSIAYRIVHENSLIFLANMTSYKKISEKALDEIEVIEKNNQDKMGDWELNQIFNPDFYNMVLIQSGIDFYNEICGVVNAHMNLYCQQTKNNYNLFKMRKLHKQILAYTSTSFEVPKMFEDDMSVYNAVNAFIDETEKGNIIGKLKDIVNKYDELDEKRIYISKDFYETLSCFMSGNWNLITGCVENFYDENIHAKGKSKEEKVKKAVKEDKYKSINDVNDLVEKYIDEKERNEFKNSNAKQYIREISNIITDTETAHLEYDDHISLIESEEKADEMKKRLDMYMNMYHWAKAFIVDEVLDRDEMFYSDIDDIYNILENIVPLYNRVRNYVTQKPYNSKKIKLNFQSPTLANGWSQSKEFDNNAIILIRDNKYYLAIFNAKNKPDKKIIQGNSDKKNDNDYKKMVYNLLPGANKMLPKVFLSKKGIETFKPSDYIISGYNAHKHIKTSENFDISFCRDLIDYFKNSIEKHAEWRKYEFKFSATDSYSDISEFYREVEMQGYRIDWTYISEADINKLDEEGKIYLFQIYNKDFAENSTGKENLHTMYFKNIFSEENLKDIIIKLNGQAELFYRRASVKNPVKHKKDSVLVNKTYKNQLDNGDVVRIPIPDDIYNEIYKMYNGYIKESDLSEAAKEYLDKVEVRTAQKDIVKDYRYTVDKYFIHTPITINYKVTARNNVNDMVVKYIAQNDDIHVIGIDRGERNLIYISVIDSHGNIVKQKSYNILNNYDYKKKLVEKEKTREYARKNWKSIGNIKELKEGYISGVVHEIAMLIVEYNAIIAMEDLNYGFKRGRFKVERQVYQKFESMLINKLNYFASKEKSVDEPGGLLKGYQLTYVPDNIKNLGKQCGVIFYVPAAFTSKIDPSTGFISAFNFKSISTNASRKQFFMQFDEIRYCAEKDMFSFGFDYNNFDTYNITMGKTQWTVYTNGERLQSEFNNARRTGKTKSINLTETIKLLLEDNEINYADGHDIRIDMEKMDEDKKSEFFAQLLSLYKLTVQMRNSYTEAEEQENGISYDKIISPVINDEGEFFDSDNYKESDDKECKMPKDADANGAYCIALKGLYEVLKIKSEWTEDGFDRNCLKLPHAEWLDFIQNKRYE
>NC_012778.1|WP_012739648.1|1473048_1474014_+|hypothetical-protein
MNNSNRTTHQKDVSLKTFWRDNEHFADLFNATVFNGKQVLKPDKLTEMDTDVSATIHSKSYNESITRNRDVVKKMSDGVEFNILGLEIQDKTHYAMPLRTMTYDALGYIKEYNDIKKHHKLNKDSFSSHEEFLSGINKSDRFHPIITLVLYYGESLWDGPTCLSDMMISMPDNIKAYFSDYKLNLVQILDSDKYTFYNEDVRDVFNIIRNIYNDDFDSIYREYESRNVDIDVMELICNITSVPKLMDLCTDTEQGGTVNMCEAMKRFQAECESKGMKEGIDSEKVNSIISMLEFGITKEQILTRYTKEDLERAEAAIANEN
>NC_012778.1|WP_012739649.1|1474072_1474945_-|N-carbamoylputrescine-amidase
MRNVKYAGIQMQCSRSVEENIAKADKMVREAAANGAQIILLPELFERQYFCQERNYDYYAFATPVDENPAVKHFQKLAAELKVVLPISFYERDINVFYNTVAVIDADGSVLGIYRKTHIPDDHYYQEKFYFTPGDTGFKVWDTRYARIGVGICWDQWFPETARGMAVQGAEILFYPTAIGSEPILEVDSMPHWRRCMQGHSACNIVPVVAANRIGEEKVTPSEANGYQESSLLFYGSSFVTDATGEIVTQASRDKEEIVYGESDLDADADLRVSWGLFRDRRPEIYKGIR
>NC_012778.1|WP_012739650.1|1474946_1476068_-|agmatine-deiminase
MDYINSTPAADGFRMPAEFERHQGCIMIWPERPGSWAYGAKAAKKAFAQIASVISESEQVYMIVSEGRKEEAAKMLPETVRLVVMDTDDAWARDTGPTFVVSGNVDTPYEARDLRGINWEFNAWGGTYDGLYAAWDNDNLVAGQFMSYLGCQGYNAAPFVLEGGSIHTDGEGTMLVTESCLLSKGRNPQLSREQIENKLKQYCNVSKIIWLPCGIYNDETNEHVDNVCAFTAPGEVVLAWTDDENDPQYEMSKACLSVLENVTDAKGRHIKVRKMLIPKKPVCITEEELNGFEFEEGEDMREAGERLAASYVNFYIANDSVIVPQFDDEADSLAINVLKEAFPDRKIVGIYARDIIVGGGNIHCITQQIPEVK
>NC_012778.1|WP_012739651.1|1476070_1477300_-|carboxynorspermidine-decarboxylase
MRFDELKTPAYVIDEKMLIHNLEILHKVEEDTGCHILLAQKAFSAYAEYPLIGKYISGTTASGIYEARLGAECMGKENHVFAPAFTDEDMDELVNICDHVVFNSVSQLKKHKARCIEAGVSFGLRVNPEFSTQGDHAIYDPCAPGSRLGVTLKNLKAALEEEPDVLSGMEGIHFHTLCEQNSDDLEATLKAVEEKFGFLMKDMKWVNFGGGHHITREDYDIETLEKCISHVKKKYDVQVYVEPGEAVALNAGYLVTTVLDKVENGITTLILDASAACHMPDVLEMPYTPPLRGGLKISDMEDEYGIDKDIEIDFDMDVKEGIWKPAKNGRYRYRLSSYTCLAGDIIGDYQFGREINVGDRLVFEDMAIYSMVKNNTFNGIQLPDIVIMDSDGECKVWKHFGYEDFKGRL
>NC_012778.1|WP_012739652.1|1477315_1478575_-|saccharopine-dehydrogenase-family-protein
MSRVLVIGCGGVASVAIHKICQVSEVFSDLCIASRTVSKCDKLADELKGKTSTNITTAKVDADNTDEVIALINEFKPDVVLNVALPYQDLTIMDACLACKVPYVDTANYECEDTDNPEWRKVYEERCKRLGFTAYFDYSWQWAYREKYKEAGITALLGTGFDPGVTSVFTAYAQKHYFDEIHTIDILDCNGGDHGYPFATNFNPEINLREVSAPGSYWEDGHWVEIPAMSIKREYNFEGVGMKDMYLLHHEEIEALAANIPHVKRIRFFMTFGQSYLTHMKCLENVGMLRTDPVEFNGQEIVPIQFLKALLPDPASLGPRTVGKTNIGCIFTGIKDGKEKKVYIYNVCDHQECYREVGSQAISYTTGVPAMIGTMLVAKGLWNKPGVFTTDEFDPDPYMDALNKYGLPWVVDENPVLVD
>NC_012778.1|WP_012739653.1|1478571_1479429_-|polyamine-aminopropyltransferase
MEFWFSELHSPHVKFDIRVEKQLFSGESDYQRIDVFQSPEFGKFLTLNGSVIFSEQDCFIYNEMVVHVPMSVHPDVKNVLIIGGGDGGVSKELLQYDNIENIDIVEQDNMFVDVCREYFPETASGLEDERVHIYNSDALRFLRSKQDMYDLIINDATDPFGASEGLFTREFYGNCYKALKEDGILVYQHGSPFYDEDEDACRSMHRKVFHTFPISRVYQAHIPTSPSGYWLFGFASKKYHPLKDFKPAEWKRRNIHTEYYTTNLHTGAFMLPKYVEELLEQEEER
>NC_012778.1|WP_012739654.1|1479476_1480931_-|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme
MDLKRQASAPLYEAIEKFRKKRIVPFDVPGHKRGRGNPELVDLLGERCVGIDVNSMKPLDNLCHPVSVIKEAEELTAEAFGAEHAFFMVGGTTQAVQNMVLSVCKAGDEIIVPRNVHKSVINALILCGAIPVYLNTEINAKLGIVLGVTVQQVEKTIQEHPNAVAVLVNNPTYYGICSDIKGICDIAHSYGLKVLADEAHGTHLYFGDNLPMNSMKAGADLAAISMHKSGGSLTQSSILLTNNGMNADYVQTIINITQTTSASYLLMTSLDISRRNLALRGRQSFAKVSEWAQYARDEINMVGGYYAYGKELINGGTVYDYDVTKLCVYTRDIGLDGIEVYDILRDEYDIQIEFGDIGNIMAYISIGDRIQDIERLVGALAEISRLYSKEEKRFEVDRQMLLPRVLASPQEAFYADKIKVPIREAAGHISGEFVMAYPPGIPILAPGEEITDEIIDYIQYSVEKGCSMQGMEDSTLQTLNVLRM

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Crispr_ID: NC_012778_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012778_3

1735464-1735667

Orphan

Consensus_repeat	Method
CTTCCCGATTTTGGACTT	CRT

3 spacers

The CRISPR arrays of NC_012778_3

>merge|NC_012778|3|1735464-1735667|CRT
CGTCCTGATTTTGGACTTTCACATGTCTTTCCACTGCTCTAACGTCCAATTCCGCGTGTCGGCTTCCCGATTTTGGACTTCCTCGTGCCTATTCACTGTTTTAAAGTCCAATCTGTCATTCTTTCTCGTCACTTTTGGACTTTCACATGTCTTTCCACTGCTCTAACGTCCAATTCCGCGTGTCGGCTTCCCGATTTTGGACTT

>NC_012778|3|2|1735464-1735667|CRT
CGTCCTGATTTTGGACTT	TCACATGTCTTTCCACTGCTCTAACGTCCAATTCCGCGTGTCGG
CTTCCCGATTTTGGACTT	CCTCGTGCCTATTCACTGTTTTAAAGTCCAATCTGTCATTCTTT
CTCGTCACTTTTGGACTT	TCACATGTCTTTCCACTGCTCTAACGTCCAATTCCGCGTGTCGG
CTTCCCGATTTTGGACTT

Protein	Signature genes	Signature genes Name	Protein_function
NC_012778.1\|WP_012739909.1\|1748705_1749095_-\|BlaI/MecI/CopY-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|367747
NC_012778.1\|WP_041688244.1\|1747005_1748619_+\|CTP-synthase	unknown	unknown	gnl\|CDD\|235437
NC_012778.1\|WP_012739897.1\|1732834_1733800_-\|tRNA-dihydrouridine-synthase-DusB	unknown	unknown	gnl\|CDD\|129820
NC_012778.1\|WP_012739892.1\|1729365_1729665_-\|hypothetical-protein	unknown	unknown	unknown
NC_012778.1\|WP_041688243.1\|1738295_1739090_-\|RNA-methyltransferase	unknown	unknown	gnl\|CDD\|223640
NC_012778.1\|WP_041688241.1\|1729657_1730131_-\|hypothetical-protein	unknown	unknown	unknown
NC_012778.1\|WP_012739901.1\|1735699_1736695_-\|ornithine-carbamoyltransferase	unknown	unknown	gnl\|CDD\|179366
NC_012778.1\|WP_041688755.1\|1733802_1734129_-\|hypothetical-protein	unknown	unknown	unknown
NC_012778.1\|WP_156327317.1\|1722966_1723107_-\|hypothetical-protein	unknown	unknown	unknown
NC_012778.1\|WP_081458321.1\|1744667_1746779_-\|ATP-dependent-zinc-metalloprotease-FtsH	unknown	unknown	gnl\|CDD\|273520
NC_012778.1\|WP_012739899.1\|1734121_1735135_-\|biotin--[acetyl-CoA-carboxylase]-ligase	unknown	unknown	gnl\|CDD\|237010
NC_012778.1\|WP_012739906.1\|1743864_1744635_+\|PilZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|377796
NC_012778.1\|WP_012739896.1\|1732251_1732728_-\|transcription-elongation-factor-GreA	unknown	unknown	gnl\|CDD\|234693
NC_012778.1\|WP_049777960.1\|1749192_1749879_-\|4'-phosphopantetheinyl-transferase-superfamily-protein	unknown	unknown	gnl\|CDD\|225002
NC_012778.1\|WP_012739904.1\|1739115_1740090_-\|6-phosphofructokinase	unknown	unknown	gnl\|CDD\|235111
NC_012778.1\|WP_012739895.1\|1730611_1732216_-\|lysine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234778
NC_012778.1\|WP_012739894.1\|1730140_1730368_-\|hypothetical-protein	unknown	unknown	unknown
NC_012778.1\|WP_012739900.1\|1735131_1735416_-\|hypothetical-protein	unknown	unknown	unknown
NC_012778.1\|WP_012739905.1\|1740196_1743763_-\|DNA-polymerase-III-subunit-alpha	unknown	unknown	gnl\|CDD\|235868
NC_012778.1\|WP_012739902.1\|1737091_1738093_-\|cell-wall-hydrolase	unknown	unknown	gnl\|CDD\|377847

Protein	Function_ID	Function_description	E-value
NC_012778.1\|WP_012739909.1\|1748705_1749095_-\|BlaI/MecI/CopY-family-transcriptional-regulator	gnl\|CDD\|367747	pfam03965, Penicillinase_R, Penicillinase repressor. The penicillinase repressor negatively regulates expression of the penicillinase gene. The N-terminal region of this protein is involved in operator recognition, while the C-terminal is responsible for dimerization of the protein.	1.60061e-24
NC_012778.1\|WP_041688243.1\|1738295_1739090_-\|RNA-methyltransferase	gnl\|CDD\|223640	COG0566, SpoU, rRNA methylases [Translation, ribosomal structure and biogenesis].	1.49759e-69
NC_012778.1\|WP_012739897.1\|1732834_1733800_-\|tRNA-dihydrouridine-synthase-DusB	gnl\|CDD\|129820	TIGR00737, Probable_tRNA-dihydrouridine_synthase, putative TIM-barrel protein, nifR3 family. This model represents one branch of COG0042 (Predicted TIM-barrel enzymes, possibly dehydrogenases, nifR3 family). This branch includes NifR3 itself, from Rhodobacter capsulatus. It excludes a broadly distributed but more sparsely populated subfamily that contains sll0926 from Synechocystis PCC6803, HI0634 from Haemophilus influenzae, and BB0225 from Borrelia burgdorferi. It also excludes a shorter and more distant archaeal subfamily.The function of nifR3, a member of this family, is unknown, but it is found in an operon with nitrogen-sensing two component regulators in Rhodobacter capsulatus.Members of this family show a distant relationship to alpha/beta (TIM) barrel enzymes such as dihydroorotate dehydrogenase and glycolate oxidase. [Unknown function, General].	6.24173e-142
NC_012778.1\|WP_012739901.1\|1735699_1736695_-\|ornithine-carbamoyltransferase	gnl\|CDD\|179366	PRK02102, PRK02102, ornithine carbamoyltransferase; Validated.	0
NC_012778.1\|WP_081458321.1\|1744667_1746779_-\|ATP-dependent-zinc-metalloprotease-FtsH	gnl\|CDD\|273520	TIGR01241, ATP-dependent_zinc_metalloprotease_FtsH, ATP-dependent metalloprotease FtsH. HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides].	0
NC_012778.1\|WP_012739899.1\|1734121_1735135_-\|biotin--[acetyl-CoA-carboxylase]-ligase	gnl\|CDD\|237010	PRK11886, PRK11886, bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA.	1.41199e-86
NC_012778.1\|WP_041688244.1\|1747005_1748619_+\|CTP-synthase	gnl\|CDD\|235437	PRK05380, pyrG, CTP synthetase; Validated.	0
NC_012778.1\|WP_012739896.1\|1732251_1732728_-\|transcription-elongation-factor-GreA	gnl\|CDD\|234693	PRK00226, greA, transcription elongation factor GreA; Reviewed.	9.92805e-63
NC_012778.1\|WP_049777960.1\|1749192_1749879_-\|4'-phosphopantetheinyl-transferase-superfamily-protein	gnl\|CDD\|225002	COG2091, Sfp, Phosphopantetheinyl transferase [Coenzyme metabolism].	2.70032e-30
NC_012778.1\|WP_012739895.1\|1730611_1732216_-\|lysine--tRNA-ligase	gnl\|CDD\|234778	PRK00484, lysS, lysyl-tRNA synthetase; Reviewed.	0
NC_012778.1\|WP_012739906.1\|1743864_1744635_+\|PilZ-domain-containing-protein	gnl\|CDD\|377796	pfam07238, PilZ, PilZ domain. PilZ is a c-di-GMP binding domain which is found C terminal to pfam07317. Proteins which contain PilZ are known to interact with the flagellar switch-complex proteins FliG and FliM. This interaction results in a reduction of torque generation and induces CCW motor bias. This domain forms a beta barrel structure.	0.00508192
NC_012778.1\|WP_012739904.1\|1739115_1740090_-\|6-phosphofructokinase	gnl\|CDD\|235111	PRK03202, PRK03202, ATP-dependent 6-phosphofructokinase.	1.48503e-171
NC_012778.1\|WP_012739905.1\|1740196_1743763_-\|DNA-polymerase-III-subunit-alpha	gnl\|CDD\|235868	PRK06826, dnaE, DNA polymerase III DnaE; Reviewed.	0
NC_012778.1\|WP_012739902.1\|1737091_1738093_-\|cell-wall-hydrolase	gnl\|CDD\|377847	pfam07486, Hydrolase_2, Cell Wall Hydrolase. These enzymes have been implicated in cell wall hydrolysis, most extensively in Bacillus subtilis. For instance Bacillus subtilis steB is expressed during sporulation as an inactive form and then deposited on the cell outer cortex. During germination the the enzyme is activated and hydrolyzes the cortex. A similar role is carried out by the partially redundant Bacillus subtilis CwlJ. It is not clear whether these enzymes are amidases or peptidases.	1.73428e-29

>NC_012778.1|WP_012739900.1|1735131_1735416_-|hypothetical-protein
MYYTTSGAYRKSKMLIDYANIALTFAIGVVFIIILFLRSGSGILFAVEFMLGALVNGLTAAKNFMSDRTVSGVILTVVTLGLLLMAVIAWRVMV
>NC_012778.1|WP_012739899.1|1734121_1735135_-|biotin--[acetyl-CoA-carboxylase]-ligase
MKTKILNVLRKSDGYVSGQALCNMLGVSRTAVWKVINQLKEEGYVIEAVQNKGYHITQYPDILTSSEIMSQLTCVDTGSTTGIIREVVYYDETDSTNNEAKRAAERDNAADGTLYITESQTGGRGRRGRNWVSPAGSGIWMSLLLRPDIAPVNASMLTIVAAMAVQEAIHTVLKEDGHDAECRIKWPNDIVLNKKKVCGILTEMSAEMDYIHYVVIGMGINVNTTEFDDSIKATASSLYLETGDHLKRSRIVAAFSESFAKYYDTFVKTQNLAGLKEDYNSMLVNKGGDVKAIYADKEIVGKAIGINDEGELIIKTDEGEKIIRTGEVSVRGLYGYV
>NC_012778.1|WP_041688755.1|1733802_1734129_-|hypothetical-protein
MFDENVVLCVSNSYEKKYYFNPDFDKLPDDVKNELKIMCVLFTEEVGGILDMEFDEEGNLLFKSSADEGDLLYDEIACGMLVKKYQYEKRELLESLEMFFKVFFLGME
>NC_012778.1|WP_012739897.1|1732834_1733800_-|tRNA-dihydrouridine-synthase-DusB
MRIGNVEIKNNIALAPMAGVTDLPFRLLCKEQGCGLMCTEMVSAKAVLYNNKNTEDLMKTVPGERPLALQLFGSDPDIMADIAKRLSEREFDIIDVNMGCPVPKVVNNGEGSALMKDPVLVGRIVEKMADALDKPLTIKIRAGFDENSINAPEIAHVIEESGGAAVAVHARTRQQYYSGHADWDIIRQVKEAVSIPVIGNGDIKSGEDAVNMMKQTGCDGIMIGRAARGNPWIFRQVSEYMNNGTIIEPPSVEEICQMIKRHAKGLCEIKGEFTGIREMRKHFAWYTAGIKHAAALRNEANQVTNLEQFDGLVDMILEGLH
>NC_012778.1|WP_012739896.1|1732251_1732728_-|transcription-elongation-factor-GreA
MAEKQFLTKKGYDERVARLEELKVVRRKEVAQKLKEAREQGDLSENAEYDAAKDEQRDIETEIAELEAILANCEVIQDNDKNKDVVKMESVVVLHDVEIDEDIEYTIVGSSEADSLNNKISNESPLGAALIGKKKGDTVKVEAPVGEIEYTVVSVKND
>NC_012778.1|WP_012739895.1|1730611_1732216_-|lysine--tRNA-ligase
MGDNKSAQQPDVNEQIKVRMEKLKNLQDAGKDPFQITKYDVTHHTDEIRAIYEAHEKELLGDRPAVNTEGLDEQQAREAVNADYNERRAIMDASPINVSFAGRMMFKRVMGKASFCNIADLKGRMQAYISRDAIGEEAYADFKKSDIGDIFGIKGFIFRTKTGEISVHAEEITLLSKSLQVLPEKFHGITDTDMRYRQRYVDLIMNPEVKETFVKRSKIIKEIRKFLDGRDFMEVETPTLVSNAGGAAARPFETHYNALDEDVKLRISLELYLKRLIVGGLERVYEIGRVYRNEGVDTRHNPEFTLMELYQAYTDYEGMMELTESMFRHLAETVCGTTKITYNGTEIDLGKPFRRLTMNDAIKEYAGVDFDTIKTDEEAKALAKERGIEFEERHTKGDIINLFFEEYCEENLIQPTFIMDHPLAISPLTKKKPSDPEKVERFELFINTWEMCNAYSELNDPIDQRERFAQQDKNAENGDEEAQHTDEDFLNALAVGMPPTGGIGYGIDRLVMLLTDSPAIRDVLLFPTMKSIDK
>NC_012778.1|WP_012739894.1|1730140_1730368_-|hypothetical-protein
MEHTKTYQEFKKNGNTKFVRYSEGAEMYHMSVSKFMQMAKDAKAIYKLGQLVLVNLKIFDEYIETFHIVDDEFYK
>NC_012778.1|WP_041688241.1|1729657_1730131_-|hypothetical-protein
MVTQLQPDVRAYLHGAEVIKRYIRVEAVAQEYGLSVEETEYIAKAAGSLYKLTRIHLVKKERFDEFMKHIYKVPGTNKQIIKKFARIGEASIIYSIGRHRFIELARAAGATYKINEGTGGTVLINLEIFDNYMEQFRQPVRPLKEPLYGQEEGELNE
>NC_012778.1|WP_012739892.1|1729365_1729665_-|hypothetical-protein
MSNSYKFYSDTKDIMKKYVNATEGAIIYGISKSRIMVLASEAGAVYKVGNSALINTDIFEMYLEKFKEPTRPLPKHIWNKLSGEDKKGHNSTCFDKKDP
>NC_012778.1|WP_156327317.1|1722966_1723107_-|hypothetical-protein
MEKAGMYVRLFFKENTTGSVRCGRGERKDTDGIKAEGVYGNGNGNA
>NC_012778.1|WP_012739901.1|1735699_1736695_-|ornithine-carbamoyltransferase
MDLKGRDFLTLKDYTPEEILYLIDLAAELKDKKKKGIVEQPLIGKNVALIFEKTSTRTRCSFEVAAHDLGMGVTYLDPTGSQIGKKESIADTARVLCTMFEGIEYRGFGQEIVEDLAKYSSVPVWNGLTNEYHPTQMLADMLTIKEKLGRLKGVKFVYMGDARYNMGNSLMIVCAKLGLHYTACTAKEYFPDKELVAQCEEWAKISGGSVTLTEDVKAGTKDADVLYTDVWVSMGEPDEVWAERIKALLPYQVNKAVMDNASKDAIFMHCLPAFHDLKTKIGKEIHDKFGLDEMEVTDEVFESEQSVVFDEAENRMHTIKAVMAATLGAYK
>NC_012778.1|WP_012739902.1|1737091_1738093_-|cell-wall-hydrolase
MKLRSSKAACYVGAAIVLFMTPVLPAVATTYEKTQNTDTGIKVASYSANTEEVLVTGYEETGTYKNKAVAITDPYLDVYDTSDEETAQVVGRLYTNTLVDVDMVGKEWTKVSSGNCEGYVQTQCLCFGEEAEAIAEQIGTDNLLAGYTMAEIEAIEAEEEAARLAEEARLEAEAEAARAAAAAEEARRQKIIANTISGTDITYNPTMSVSDDDIWLMACIIDWEAAYQPYAGKLAVANVILNRVRSGHYPGTVSGVVYQRSQFSGVSDGAGNPSDRFAARLANGPRNTECMQAALEALSGVNNIGGYTSFRALYTVDVNNYSDFVIIGDHIFH
>NC_012778.1|WP_041688243.1|1738295_1739090_-|RNA-methyltransferase
MITSTSSSQVKHVISLLSKARERKKNKEYVVEGVRMVSEVPADLLVKIYMSERFHSNNPEYVHELVKKQGISSDSIEIVADNVFDRMSQTQTPQGIMAVVRMKDSSISDMLTDNPLLILVENLQDPGNLGTILRMGEGAGVTGVIMSSNTVDIYNPKTIRSTMGSIFRVPFVYVQDFSDAVSQCKNAGIKVYAAHLDGKNTYLGEDYREGTAFLIGNEGNGLTEDITKQADTLIRIPMQGEVESLNAAIACTILTYEAVRQRSV
>NC_012778.1|WP_012739904.1|1739115_1740090_-|6-phosphofructokinase
MAKEIKTIGVLTSGGDAPGMNAAIRAVVRTALNKGLKVKGIQKGYNGLLNDEIIDMDKRSVADIIQRGGTVLYTARCMEFMTEEGQKRGAEVCRKHGIDGIVVIGGDGSFRGAQKLAAQGINTIGLPGTIDLDIACTDYTIGFDTAVNTAMEAIDKIRDTSTSHERCSIIEVMGRNAGYIALWCGIANGAEDILLPERYDNDEQALINHIIEGRKKGKKHHLIINAEGIGHSTGMARRIEAATGIETRATILGYMQRGGSPTCKDRMYASIMGAYAVDLLAEGKSNRLVAYRDGKFVDYDIDEALAMTKDINDYEFNISALLSK
>NC_012778.1|WP_012739905.1|1740196_1743763_-|DNA-polymerase-III-subunit-alpha
MSFTHLHVHTEYSLLDGSSKIKEITKRAKELGMDSLAITDHGVMYGVIEFYEAAKKAGIKPVLGCEVYVAPGSRFDKGAGQSEDKYNHLVLLAENNTGYQNLMKIVSKGFTEGFYYKPRVDKEVLREYHEGIIATSACLAGEVQRYLSRGMYETARDAALELQDIFGKGNFFLELQDHGIAEQHYVNPQLMRMHNETGIELVCTNDVHYTYADDVDAHDILLCIQTGKKLSDENRMRYEGGQFYLKSEEEMAELFKYAPEAVENTHKIAERCNVEIEFGVTKLPAFDVPEAYGKNSWVYLNALCYEGLKKRYPDKTADICIEDIIEQAKASIVADRKDVVIKRAEDSNDIFQRLSYELSVIYSMGYVDYFLIVWDYINYAKTHDIPVGPGRGSAAGSLVSYCLGITTLDPVKYNLVFERFLNPERVSMPDIDVDFAPEGRQKVIDYVIEKYGKECVCQIITFGTMAARAVIKDVGRVMDLPYAMVDNIAKMIPQKVGVTIDSAMNGDADRDIKPNAEFKALYEADETVRDLIDKAKRLEGLPRHASVHASGVLISQKDVGEYVPVAVGADNVKVTQFEGPTLEHLGLLKFDFLGLRNLTVIQQTEKCEQQIDPAFSVDNIPYNDKAVFECISQGKCAGIFQLESGGMKNFMKELKPDCLEDLIAGISLYRPGPMDFIPQYIKGKENAGNITYECPQLEPILEPTYGCMVYQEQVMQIVRDLAGYSWGGSDNVRRAMAKKKLDVMEQERQNFVYGNEANGVPGCIKNGISEQTANKIYDEMMDFAKYAFNKSHAACYAVVAYQTAYLKVHFPVQYMAWLISSVTDKTSKVAEYILAAREMGISILPVDVNKSVADFGVEGKNIRFGFNAVKSMGRPTITAIIEERTNNGDFHSMQDFITRMAGVINKRTVEHLILAGAFDTFGNTRRGMMNVYERMIDSAVKQNKDAISGQMSLFDFASEEDKQSLEMRVPDIQEFEKEDLLEREKEVLGVYVTGHPLDEYTGMWEKHISARSTDFLIDEETGQAKLMNGSKQTIGGLISNIKVITTGSGQQMAYLTIEDFVGSVEVIMFPRNYEKYKRFFDTTNKVFITGRIQADADKPARLMADSVVSFDSVPRRLWLRFDSLAEYETHRDELADIFKESDGKDTVTIYCVAEKQRIVLPQSQCVKVTSDLLYILKSKYGEKNVATT
>NC_012778.1|WP_012739906.1|1743864_1744635_+|PilZ-domain-containing-protein
MLISDIPVGGPISIEISIDNVSYEMPSSVVASKNGYILIAPFTSKGAVIDFSSYKDILFNLYTIDPSTQNRVVWKNINIETIGYKASDFSSAYYKISTNVFASIASECDRRFNQRISTEASGSITLNSDNEIIPVTLIDVCNKGLSFSINNKTAPDYNNIYITFSDIANGKQFNFHFKCVIIRSQISGERCICGCVVPAPSREYLTYVFLKKIEYRINASKEQEQQNALKDAAYVASQSIDNTSSGFHSHISSKSR
>NC_012778.1|WP_081458321.1|1744667_1746779_-|ATP-dependent-zinc-metalloprotease-FtsH
MDNYNNNGYDNGYNNNDNRNNNRNNNNNNKKPKNVNLIIFIIIAAVVTFIGLTLLSNMFRNATYKEISYDQFMQMIDEDKVKKVALEQDRILITPVEEEKQSGIAGVSYTYYTGYVNDDTLVPLLKRKGIEFEGYIPDSSSSIVEFLLAYVLPFLFIYIIFAFVYRRIAKNGGMMGGMGVGKSNAKVYVQKKTGVTFKDVAGQDEAKESLTEIVDFLHYPEKYAKIGAKLPKGALLVGPPGTGKTLLAKAVAGEADVPFFSLAGSDFVEMFVGVGASRVRDLFKEATKQAPCIIFIDEIDAIGKSRDSKYGGGNDEREQTLNQLLAEMDGFDSSKGIFILAATNRPEVLDKALLRPGRLDRRITVDRPDKKGRIETLKVHSKDVLMDDTVDFDEIAMATSGLVGSDLANIINEAAIAAVKNGRNVVTQKDLLGAFDTVVAGKEKKERVLSKKEKQVVAYHEIGHALIRAIKNNSDPVQKITIIPHTNGSLGYVLNFPEEEKHLETKDELMTDLISLVGGRAAEEVVFGSVTNGAYDDIKKATNLAKTMITRYGMSDRFGLVALSTVEDEYLSGRASMNCAQATEAEVDDEVKKLIASCYEEAKQIIRDNRDVMDQLARYLYDHETITGKEFMKIFREAKGIPEPVDTSLFSTSEKVAESVTFNDDGSYSSTVSGEPESDIWKNITKHDDSDSNASDDTTKDDE
>NC_012778.1|WP_041688244.1|1747005_1748619_+|CTP-synthase
MAVKYVFVTGGVVSGLGKGITAASLGRLLKARGFSVTMQKFDPYINIDPGTMNPIQHGEVFVTDDGAETDLDLGHYERFIDESLNKNSNVTTGKVYWSVLQKERRGDFGGGTVQVIPHITNEIKSRFFRDYSTDETKIAIIEVGGTVGDIESQPFLEAIRQFQHEVGHENAILIHVTLIPYLKASGEMKTKPTQASVKELQGMGIRPDILVCRTEHPLEAGIKDKIALFCNVPKSHVLQNLDVEILYDAPLAMEEEHLAQVACECLHLDCPEPDLDEWRAMCKAWKNPTKKVTVALVGKYIQLHDAYISVVEALKHGGVYNSCDVTIKWIDSETVTPETADELLSDVSGILVPGGFGDRGTEGKIEAIRYAREHNIPFLGLCLGMQLSIVEFARNVIGYDDAHSVELNPNTTHPVIHLMPDQEGIDDIGGTLRLGSYPCVLDKTSKAYELYGEELIHERHRHRYEVNNDYRKVLTENGMMLSGISPDGRIVEMIELKNHPWFVATQAHPELKSRPNRPHPLFRGFITAALEYQDKNH
>NC_012778.1|WP_012739909.1|1748705_1749095_-|BlaI/MecI/CopY-family-transcriptional-regulator
MSRNHFNELSPCEALIMKLIWEAPQDIPVQELIDQLRDDYGKEYARTTVVTFVGKLKDKRFVDTYRKGKSAFIHPLRSEEEYRRQLLKEEADFWFNGKAVDMVASICESQKLEDDEIKRIKKILNGLNK
>NC_012778.1|WP_049777960.1|1749192_1749879_-|4'-phosphopantetheinyl-transferase-superfamily-protein
MMIFVTTTDALADEKLYEKAYSLIPEYRKVKADKMKMRENKLQTVTAGLLLNYAVGKWSIKKGEKDYKTDEILYETVDIISVIEANNQYFDYEIAYNSQGKPYFLSNCEIFFNISHSSNYVACVIGDRPVGIDIEKTREGRQNLAKRFFDISEAEWIKECDSDERFFRIWTLKEAYGKATGQGVLDILGKIVYRLEKGKMSAYMCGFPQNFTIVEKEVDGFRLSAIQL

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Crispr_ID: NC_012778_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012778_4

2090720-2090897

Orphan

Consensus_repeat	Method
ACTTTCTCTCGGCTTCACACTGCTTTAACGTCCAATTTCGCGTGCCGACTTCCC	PILER-CR

2 spacers

The CRISPR arrays of NC_012778_4

>merge|NC_012778|4|2090720-2090897|PILER-CR
ACTTTCTCTTGCCTTCACACTGCTTTAACGTCCAATTTCGCGTGCCGACTTCCCGGGATTGGACTTCCACACGGCTTACCACTGCTTCAACGTCCAATCCGTCATGCTTTGGCGCTCTTTTTGGACTTTCTCTGTGACTCACACTGCTTTAACGTCCAATTTCGCGTGCCGACTTCCC

>NC_012778|4|2|2090720-2090897|PILER-CR
ACTTTCTCTTGCCTTCACACTGCTTTAACGTCCAATTTCGCGTGCCGACTTCCC	GGGATTGGACTTCCAC
ACGGCTTACCACTGCTTCAACGTCCAATCCGTCATGCTTTGGCGCTCTTTTTGG	ACTTTCTCTGTGACTCACACTGCTT
TAACGTCCAATTTCGCGTGCCGACTTCCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_012778.1\|WP_012740236.1\|2091645_2092563_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213231
NC_012778.1\|WP_012740242.1\|2097431_2098238_-\|TatD-family-hydrolase	unknown	unknown	gnl\|CDD\|223162
NC_012778.1\|WP_012740239.1\|2093918_2095043_-\|hypothetical-protein	unknown	unknown	unknown
NC_012778.1\|WP_041688850.1\|2092918_2093389_+\|nucleoside-deaminase	unknown	unknown	gnl\|CDD\|223663
NC_012778.1\|WP_012740228.1\|2080813_2085247_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274008
NC_012778.1\|WP_041688852.1\|2096317_2097172_+\|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA	unknown	unknown	gnl\|CDD\|234708
NC_012778.1\|WP_012740243.1\|2098243_2100217_-\|methionine--tRNA-ligase	unknown	unknown	gnl\|CDD\|237028
NC_012778.1\|WP_012740232.1\|2088147_2088498_-\|YbaB/EbfC-family-nucleoid-associated-protein	unknown	unknown	gnl\|CDD\|234669
NC_012778.1\|WP_148231352.1\|2085939_2087457_-\|hypothetical-protein	unknown	unknown	unknown
NC_012778.1\|WP_041688322.1\|2093391_2093931_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|224584
NC_012778.1\|WP_012740229.1\|2085233_2085950_-\|hypothetical-protein	unknown	unknown	unknown
NC_012778.1\|WP_012740240.1\|2095123_2096152_-\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NC_012778.1\|WP_012740227.1\|2077895_2080682_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|188437
NC_012778.1\|WP_049777967.1\|2100406_2102215_+\|DUF885-domain-containing-protein	unknown	unknown	gnl\|CDD\|377577
NC_012778.1\|WP_012740225.1\|2074368_2075523_-\|hypothetical-protein	unknown	unknown	unknown
NC_012778.1\|WP_012740226.1\|2075868_2077857_-\|transketolase	unknown	unknown	gnl\|CDD\|223100
NC_012778.1\|WP_012740224.1\|2072283_2074368_-\|hypothetical-protein	unknown	unknown	unknown
NC_012778.1\|WP_041688320.1\|2088497_2090135_-\|DNA-polymerase-III-subunit-gamma/tau	unknown	unknown	gnl\|CDD\|235505
NC_012778.1\|WP_012740235.1\|2091055_2091610_-\|prolyl-tRNA-synthetase-associated-domain-containing-protein	unknown	unknown	gnl\|CDD\|239827
NC_012778.1\|WP_012740231.1\|2087551_2088148_-\|recombination-protein-RecR	unknown	unknown	gnl\|CDD\|234616

Protein	Function_ID	Function_description	E-value
NC_012778.1\|WP_012740236.1\|2091645_2092563_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213231	cd03264, ABC_drug_resistance_like, ABC-type multidrug transport system, ATPase component. The biological function of this family is not well characterized, but display ABC domains similar to members of ABCA subfamily. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	1.79011e-82
NC_012778.1\|WP_012740242.1\|2097431_2098238_-\|TatD-family-hydrolase	gnl\|CDD\|223162	COG0084, TatD, Mg-dependent DNase [DNA replication, recombination, and repair].	1.28884e-100
NC_012778.1\|WP_041688850.1\|2092918_2093389_+\|nucleoside-deaminase	gnl\|CDD\|223663	COG0590, CumB, Cytosine/adenosine deaminases [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis].	3.57879e-62
NC_012778.1\|WP_012740228.1\|2080813_2085247_-\|hypothetical-protein	gnl\|CDD\|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	4.65677e-14
NC_012778.1\|WP_041688852.1\|2096317_2097172_+\|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA	gnl\|CDD\|234708	PRK00274, ksgA, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase RsmA.	1.96106e-137
NC_012778.1\|WP_012740243.1\|2098243_2100217_-\|methionine--tRNA-ligase	gnl\|CDD\|237028	PRK12267, PRK12267, methionyl-tRNA synthetase; Reviewed.	0
NC_012778.1\|WP_012740232.1\|2088147_2088498_-\|YbaB/EbfC-family-nucleoid-associated-protein	gnl\|CDD\|234669	PRK00153, PRK00153, YbaB/EbfC family nucleoid-associated protein.	9.07588e-45
NC_012778.1\|WP_012740227.1\|2077895_2080682_-\|hypothetical-protein	gnl\|CDD\|188437	TIGR03922, T7SS_EccA, type VII secretion AAA-ATPase EccA. This model represents the AAA family ATPase, EccA, of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccA1, EccA2, etc. [Protein fate, Protein and peptide secretion and trafficking].	2.61818e-08
NC_012778.1\|WP_041688322.1\|2093391_2093931_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	3.33692e-14
NC_012778.1\|WP_012740231.1\|2087551_2088148_-\|recombination-protein-RecR	gnl\|CDD\|234616	PRK00076, recR, recombination protein RecR; Reviewed.	1.9932e-119
NC_012778.1\|WP_012740240.1\|2095123_2096152_-\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	2.21436e-43
NC_012778.1\|WP_012740226.1\|2075868_2077857_-\|transketolase	gnl\|CDD\|223100	COG0021, TktA, Transketolase [Carbohydrate transport and metabolism].	0
NC_012778.1\|WP_049777967.1\|2100406_2102215_+\|DUF885-domain-containing-protein	gnl\|CDD\|377577	pfam05960, DUF885, Bacterial protein of unknown function (DUF885). This family consists of several hypothetical bacterial proteins several of which are putative membrane proteins.	5.33322e-77
NC_012778.1\|WP_041688320.1\|2088497_2090135_-\|DNA-polymerase-III-subunit-gamma/tau	gnl\|CDD\|235505	PRK05563, PRK05563, DNA polymerase III subunits gamma and tau; Validated.	0
NC_012778.1\|WP_012740235.1\|2091055_2091610_-\|prolyl-tRNA-synthetase-associated-domain-containing-protein	gnl\|CDD\|239827	cd04335, PrdX_deacylase, This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the YbaK and ProX proteins, and the prolyl-tRNA synthetase-editing domain (ProRS-INS), specifically hydrolyzes Ala-tRNA(Pro). In this CD, many of the eukaryotic editing domains are N-terminal and cis-acting, expressed from a multidomain ProRS, however, similar to the bacterial PrdX, the mammalian, amphibian, and echinoderm PrdX-like proteins are trans-acting, single-domain proteins.	1.49736e-64

>NC_012778.1|WP_041688320.1|2088497_2090135_-|DNA-polymerase-III-subunit-gamma/tau
MSYQALYRKWRPDNFNDVKGQDTIVTTLRNQINADRIGHAYLFCGTRGTGKTSVAKIFAKAVNCEHPVDGNPCGECPTCKAIAAGTSMNVIEIDAASNNGVDNIRQIREEVQYSPTEGRFKVYIIDEVHMLSIGAFNALLKTLEEPPAYVIFILATTEVAKIPITILSRCQRYDFHRITIETIAGRLSELMKAEGLNVEDKAIKYVAKAADGSMRDALSLLDQCLAFYLGKDLKYENVLDVLGAVDTAVFSKMLSTILSGDVAVCMSLMEDLIMQGRDLSQFVTDFIWYLRNLLLIKTTKDAERIEDVIEVSADNLEDLKKDAQNVDIDTLMYYIRVLSELSNDLKFSTQKRVKTEITFIKLMRPAMDNSQDIGDVVSRVTMLEGQLQKVLDDIKSGKLVSTAGMAGGAAGSQAAVQQQTSKKPVVKRVYDAVPEDVKAIAAGWKDIIATIDDPVNQTFLQAAHVTLAEDGISLEIMVESLSAYNSLSRQEVMESIENVIEERTGVRVSIKVTKLNDDEDFHSRFVDLKELVGIDIEVDDKEELI
>NC_012778.1|WP_012740232.1|2088147_2088498_-|YbaB/EbfC-family-nucleoid-associated-protein
MAKRGGFPGGMPGNMNNLMKQAQRMQRQMEEQQAELENKEFSATAGGGVVEVTVTGKREVSKVKIDPEAVDPDDVEMLEDLIVAATNEALRKCEEESQAQMAKITGGLGGLGGGLF
>NC_012778.1|WP_012740231.1|2087551_2088148_-|recombination-protein-RecR
MDIYSGHINRLIEELSRLPGVGAKSAQRLAFHIINMPESEVKSLADTMIDAKQHIHYCKECFTLTDEELCPICRDQKRDHKTIMVVEHTRDMAAYEKTGKYEGVYHVLHGAISPMLGIGPADIRLKELMVRLQGDVDEVIIATNSNLEGETTAMYISKMIKPTGIKVTRIASGVPVGGDLEYIDEVTLLRALDGRTEL
>NC_012778.1|WP_148231352.1|2085939_2087457_-|hypothetical-protein
MAENMTGDIISDHRERMLNLKKYYPFFRLIDTSFSNFKDGKYEILDMGYIVMAVLRFFIEENNFKEKDVTYPEYLDFLRLILKRDFGLDLNEQDSKEIADYIFDKIKNDGRPFEFSYFDPVDRKKRVSRMKIIESSIRDNTVWYSISPDAIEFYLDTKEIKDESRISVSQLLLEKMINSQNFRGGVEVVERINEEVNRLKLKKNEVLTILSGDVFAGIEAYEEFVKTGMKWFDDEEKLFKKNRDLIAKSIEKLNASGSTGEGYYRTMNEIYSLETQLKQAMNRHSELLKDCTEMQKMTDDAVRRAKLGRLRSHMDFTSALSDMIKRDNADILVTMLSPLLKPNIRKTFDLISIDDALMVKPPRYEEKELISNERPEDIEFEDEIEEKRIKDNYVFLMKNLIVCLKKSDIITLGQFADAMKRAYGEQILRNADFFSFFVNLCQKDEYQLGGDAGEDTFLDAYLGEGFKDTESFTFAIRKGLGGQVILSDNCMMADVELVRKEAHGE
>NC_012778.1|WP_012740229.1|2085233_2085950_-|hypothetical-protein
MENRNLDKALDIVSKLITGENVSERGENAALYQEYNNNAEVYDIVHMSLKKLNLNIYEYNNGLYVSAGDNNRVFGYSNEELRNVLGLRVNKELYLAYFIIYNIITEFYSDTMSSTYAEFIRLEDIIKNVDKTTGGIVDKSAGLVLDEVEENSFKQIALTWDELPVTTVEDQTGARAARNSKSGMVKLVLNFCVAQELLVESQDRYYPTDRFRSLIENYFDDYRGRFAELMNGGRDATD
>NC_012778.1|WP_012740228.1|2080813_2085247_-|hypothetical-protein
MPQINRIRVNNVKYNFGTQVYDDFVMRFNCQNTIYDLANGGGKSLLMLLLMQNMLPNCTLDDKQPIEKLFRQGSGNTCIHSLVEWKLDPCYQKDGFRFMTTGFCARKGRGTDDENQDGQEQTAAPTASVEYFNYCIFYREFGDNDIKNLPLVSNGERITYNGLKAYLRDLEKGGYKYVVKIFDRKGDYQSFISNYGIYESAWEIVRGINKTEGHVRTYFESNYKTSRKVVEDLLIEEIIQKSFNNKLSVDNDEGMMAKTLMDIKDKLVELSKKHSQLGAYDSQIAAIDSFKEYLSTYEAFYNRKEEIEKQLYDLLLVAMRESDKKDKELKSQDDLITKMYDELAQEKEAIAVAEVMSEKNSMAGVESLVNETRKALELKNTAIEEARGKLSLMESAGDYKDYAEYEKSYKGLQIAIDNRLREDTDITAELKILVAGYRKFYETETKRLKEKLDIAANRVKALEVRLSEAKDNLRNADKEAAGLGSLSDNLENEIQELQTQLGAALSDAGTVVCENASEEYDKSFSDKELLKNEETRMSEKFNDVQQQLMSLNETISANKALIDIFTEQSEKLEKADEAGNADNERMGKIREIYSADNDEAMLSVILETYQKMRSEYTEECKAAQELDSFIDNARKGTYICKSPERDRLKEYLESQYGSDVVEGHEWFAALNAGQKRDVLKRTPFVEYAFIIKNDFERIKADEMLKDFGKGAAAYPVISEQVLIDTKLEINKDLIVFALKDMSFLRDEAKLETQIKLAQEELDSHKAQAGKLADRMGLVWNDYTFALVYNAASGKVDASEAEAIRLKIADSEAAIIEAEKKRSALNVAKEQLAGQLSQTRAYIEEKENSCRILSQIIDMNSSIDKKYEKLKSLKADSEAARNRIYECEEAAASANSEYDTARDFEDSTRKEYEEIIKSWEEQYAPYYDENVSIEIDDDTYRLDKDEIESRFTGLKTALSQKNSDFADKQALMNHLSASMNKCRDAIEYRGYTFDDIKAKYEAGEIMAAGSQQLRNAKDALNNLVKSSDAVREELESQEALLNRLEGSIAHGINQIENNYGSFNEFPCDDPDGFITQHKVLIKKLEDNTKVQEKTRRQMSDSLKDILVCRKDLERIVSDAGMHVPEEFRPEDAQGITANLTEYEAVHKEYASITRLEYKKVDEFNKNKSKLIDLLNGFNAVELADEVRISLNVPENVVKTRSMIESLNETNTFIQLEKDRIAKGIEDMQMIKDNFENRCIQTCSNIKTELDRLPQLSNINLDGEQIAIISLQIPYIKEELYKEKMSEYIDETVFMAESFKEPAERLKYIRNRLSWKRLFSVIVTDMNSIRINLYKRERIKDQSRYLRYEEAVGSTGQSQGIYIQFLIAIINYISNMNSSGNEGVEGKTIFIDNPFGAAKDIYIWEPIFKLLATNHVQLIVPARGATPAITGRFDVNYILGQKLVDSRQQTVVVDYYSSTKESELEYTRMDYEQATFDFL
>NC_012778.1|WP_012740227.1|2077895_2080682_-|hypothetical-protein
MNKYELGIKIDQIKKLAAKKDYAEAAAIAKELNWSKVKDWQSLATAINVQEAVGDYEEARDMAILAYNRNLGGRKLVYKLTEFFIKVGDFENANELYEEYSRTSQHDVSRFILLYDLKKAQNASDNELVGILEDYRDHEIDEKYMYELATLYYKTGRKEECVKTCDNIVLWFQDGRYVEKAVQLKEQLGVTLTKTQKGILEDVKKRKDDIEAAKEELFAKQKELIDLKRDDVEDVFREEDEKISELPKKAAQTPKEVHLNVPEYDRQQEEGPLSMDLVQNDQNNDIKEFIMKALSKNSDNSKSQLSEQEASVRKIETPQVEKPEVAEALSEAGEKAFSNEINKANLSLKELIANAKQKLDNNYDKINKEDEAEQRRETEARINEKAKNIDINVPVPDYSLYDTRNLQEELAANMSDLFRADEEDEDVKTFVPASKHQDEKQEEKEPVKENAMAVSVNTDTVDETEGTETSDDDQIEGQMDITEWMQSVREEKYGKQDTREFSKSELERYLDEKEEKSAAYEKMVERKKAEALVAGKEIDKEEAKQVALAQMAVDSARMDLAIRTGKAAARLEQEAAKAAAAVTKKAPVNAEEPSEEIPLVTAQIPTVSESMISDINSIMNDDNNKEEGDEAVAQQEAAAGVEPEETVPFTRQNRQPESMEEYNTDNDEVEEEKDKKLTGELAKIFRKYRDMPGLEEQLVDLFDTIDDEMQINTSKVGNILISGNSSSDKTDLARTIIRAINTLYPDKQKKIAKTSGESINQRGIAKAMGRLKGTALIVEGAGTIQPKRINELLNCLEQDTDRMIVIFEDSDTDMNVLINFNPELTNTFNHRIILKQYTVNELVEMAKRFARKRQYEVDDDALLELYLKIDKLHNVNDNIKLDDIKEIINQAIVNSERRASRRFFGGLKKKRSENGDVIFLTEADFKDR
>NC_012778.1|WP_012740226.1|2075868_2077857_-|transketolase
MTNIDEMSINAIRVLSADAIQKANSGHPGLPLGTAPTAYELWTNHMNYNPADPKWENRDRFVLSGGHGSMLLYSLFHLLGIGNLSLDDVKNFRQMGSKTPGHPEYGHTVGVEATTGPLGQGMAMAVGMAMAEAHLASVFNKDGYNVVDHYTYVLGGDGCMMEGISSECFSLAGTLGLSKLIVFYDSNNISIEGSTDIAFTENVMKRFEAFGFQTIEVADGNDIEAIGKAIEEAKADKERPSLIKVNTLIGYGCPAKQGKASAHGEPLGIDNVAALKENLNWPCKGDFEVPQEVYDHYKEIAARMAEPEKEWNKLFAEYCEKFPEMKELWDKYYNGCDMSDLFNSEEYLAKPEKAEATRSSSGTILNMIKNLMPNLIGGSADLAPSNKTNMKDAGDFSKENYAGTNLHFGVREQAMAAIGNGLALHGGLRPFVATFFVFSDYTKPMARLTSLMKLPVVYVFTHDSIGVGEDGPTHEPIEQLAAFRSMPDFTVFRPCDRTETALAWEYAIESKDEPTALVLTRQNLPQMAGSSKEALKGAYILEDSDKETPDGIIIASGSEVNLAVSAKAELKNAGIDVRVVSMPSMDVFEKQSDEYKESVLPKSVRKRVAVEALSDFGWYRYVGLDGKVICMKTFGASGPANQLFEHFGFTVENVVNTVKSLF
>NC_012778.1|WP_012740225.1|2074368_2075523_-|hypothetical-protein
MRRIAAGLIVIMSVLLVSCKGKTGNTITVGSDKLDNTQSYFSESMHMVARCDTGYYYLDKCSASDDNLMFYDDKSEESIVLCNKPQCGHDGEECMAYISGSEFKSELYYYNSYIYMISSKGNLVQISADGTQRTDLGSICVLSGQDSVSMCFNDGYAYVSQEITGDIEGNVTVRLYRFNLDTGSSDKIYEETGYGIGINSLKTYGSDTFFLKTSVSKDDKGLYSLEGKGIFRITGENTECLLDKNVYSYCIDADNNKLYYSGLGDGTIYEYDLGSGKSESIYKSDNDTGYFYITFDGNYIWMDDEGYKSMAMYFNKQSSSLDYTIYQLGLDGKLIAKRTIPDEEKIFSIMHGDSRKMFMFSSVNNRIVYIDKSNIEKGDIKELR
>NC_012778.1|WP_012740224.1|2072283_2074368_-|hypothetical-protein
MKELGRLLNRKTILLILAAACICVVAVFAGDFSDCGIDNYKIKVREYNWLINGHTDEQIQEHADELAQDERRIFKRLAKEYKEKSDYIDGYTESVKAVITNASNMKKFSVFGTSESIANINKTENDYKRIENVQVRELNSRAVEQFLKNDISIYIVLALMIYIIYNIYEYRDNGMWQIIYTAVNGRIRLAVKDTAAVGLGALFVSLIMQLCGLVSMLVVYGGWDFLIAPVQCLTGYNNFTYPISVMTYLFIRYMIISLIVIAIVLVISLVFALCRKRISSIVLVGIIAGAEAFAYQNISMQGRLRIFKKINIINVMDVSNILRKYDNIMIAGVPVSMVNVLCMVCIIIAVISAIFLALLGKVIRPGRSAGFIGKMIEKIGHGVQRILSRLPHFWKEMYKFLITARGWIVICVVVFITIFICNNQKIAYSEDEKKRDEYYQQYGGRDYSGFTSLIDQRQNDVYEAQAKLDAAREQYERGELSEDDVSRYVYNLMDAARLLDNMSEYMQQIEYVSQIKEQYGIDAFVMSQRGYDQIFGSKGATRKLLIYIILGFGVVLIAETESSVEYKNGMNMLIGSSKRGRRWEHTVKAAAVCILVGASAFLLYIIEMIIMYKAYGMPYINAPLISLTYMNTAKVFRNITISQYMLVLMAEEILFAVAVGLETVFASRHIFKKNSGKGIPLIIVINTAILCIIM
>NC_012778.1|WP_012740235.1|2091055_2091610_-|prolyl-tRNA-synthetase-associated-domain-containing-protein
MELIKGRPADETGRLEKEIRVYDLLDKLGMEYYRTDHEPATTMEVCNDIDKILDTLICKNLFLCNRQKTNFYMLMMPGDKPFKTKDLSKQINSARLSFADESYMEEFLDITPGSVSIMGLMNDTDNHVQLLMDKEVLEGESLGCHPCINTSSLKLKTKEVMEKFLPAVHHEAVIVELPRYDISE
>NC_012778.1|WP_012740236.1|2091645_2092563_-|ATP-binding-cassette-domain-containing-protein
MKLEVRNLKKTYGTVQALKGINYTFTPGVYGILGANGAGKSTMINLITDNVSRDKMNGGSILFGEDSAEEDILKLGKQFRGLVGYMPQQQGFYEDFSPKAFLKYMAEIKGVKKIKTTDDNGNEVVKTVNQQIDELLEVVNLTKVAYKKIGGFSGGMKQRVLLAQALLGNPKILILDEPTAGLDPKERISIRNYIAELSKDKIILFATHVVSDIECIADKVLLLKSGEIIATGTPVELIESMAGKVGEITCTLDEVGELQKEYKIGNIRQRKNGLALRVVGDELPEEAVKVGDNIDLEDVYLYYFE
>NC_012778.1|WP_041688850.1|2092918_2093389_+|nucleoside-deaminase
MKQAITQAKKAYKLNEVPIGCVIVYEGKVIGRGYNRRNTDKTSLGHAEITAIKKASRYMNDWRLENCTLYVTLEPCQMCAGAIVQARIPRVVIGSMNPKAGCAGSILNILQIPTFNHQCEITKGVCEEECSEMLTTFFKELRKSKKKNTTVTTDGE
>NC_012778.1|WP_041688322.1|2093391_2093931_+|GNAT-family-N-acetyltransferase
MKFEYDFEGMKLKVLDETFAGKVLEFYSRNREEFDRYEAAKPDNFYTTEYITATLKAEYAALLKGEFGRFFLFSDDMPGEILGSVSFFGVTSINRSCRIGYKIDKNYRQLGLGSLMVKHMLEILTHEKEMHRIEAYIHPQNISSINLVKSLGFISEGTAYSYVKLNGSWQDHLRFVYIS
>NC_012778.1|WP_012740239.1|2093918_2095043_-|hypothetical-protein
MDYQRLVSYIYSYPEGVKGRNAGFAKALVHQGQFKLSISLRGVKTDSPEMFGIYMMVTDSGYRLIKLGECLVKMGQMEYSGVFNPDNINDTGYSFRDICGLAVAMEDARYDCMLSMWKDEDVTPDMLVFSGMDAKKQAEAGIVIKERMRQSEEKERGQQMSESVLAESLRSEPVRPELSESQTLESQMAQAEPAVSAGRPQAVQSKQAEAYRPQTGVTAESVSDTATEDIKAAGAAAKIPAETQHLQQKAHRANATQTDPFEKLFVRADYIDAFDDDYFYDCIEVSPEKLKCLNQNEIDITGNSFLLHGYYNFRHILFGRVRDNLDNTKYFVGVPGMYCNRERYMASMFGFNNFKKSHRSDYANPYFGYWYQEI
>NC_012778.1|WP_012740240.1|2095123_2096152_-|GGDEF-domain-containing-protein
MSINKKEFNLEQVVKLCVVVNISLFLFVAFMLTLFVYFNITPMIYYSVIALIGYVLYFMLLKRQKVCAYMWCVYATIIIYMAIATICLGYKCGFHLYSMSLIPIIFYSQYISTKTDTKDPNPLAVSIAIVAVSIISSAIAIINGPLYEINKTIISVMLACNAISVSAFLIYYTKVIVDLVIESEKKLNSIANIDLLTDLYSRRYMINYLEEYDADDEGWLAMADVDDFKKINDTYGHNCGDYVLNFIAQKMKNICSNCVISRWGGEEFLIHNGTHDSTHEVLEKLRREIENSECIYKQQKINISLTIGVAQRNADGDIEEWIKSADDRLYYGKNNGKNMVVD
>NC_012778.1|WP_041688852.1|2096317_2097172_+|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA
MHLGNPTNTIAVLNRYGFDFKKKFGQNFLIDENVVEKIVREAGVTKDDFVVEVGPGIGTMTQILCENAREVVAVEIDKKLIPILTEDTLSYYDNVTVINEDILKLDIKKLADEKNEGRPIKVVANLPYYITTPIIMGLFESHVPLDSITIMVQKEVADRMQCGPGTKDYGALSLAVQFYAKPKVVLNVPASCFMPRPNVDSAVIRLERFKTPPVDVKNEHLMFKIIRASFNQRRKTMLNSVGNSGIGITKEALTNALETMGLPLTIRGEALTLEQFAQLSNLLC
>NC_012778.1|WP_012740242.1|2097431_2098238_-|TatD-family-hydrolase
MKIFETHAHYDDERFDEDRDELISSMLSDTGELDYIVNVGASRQGCEASLALAAQYEKVYAAIGFHPEDIVRLKESDIEWLENMLGESKARKIVALGEIGLDYYYVSDDADMAAAEKKQQREWFAAQMNIAYRTHMPVMIHSRDACQDTIDILKSNHGQDTGGIIHCYSYSKEAARDFLNMGFSIGIGGVLTFKNAKKLVEAAAYIPMDRIVLETDSPYMAPEPNRGKRNDSRNIKYVAEKLAQIKGLDTQEVIDVTNQNARRLLFGE
>NC_012778.1|WP_012740243.1|2098243_2100217_-|methionine--tRNA-ligase
MPQSKGPFYMTTAIAYTSGKPHIGNTYEIVLADSIARFRRQEGYDVFFQTGTDEHGQKIELKAEEAGITPKEFVDNVSTEIKRIWDLMNTSYDKFIRTTDDYHEKQVQKIFKKLYDQGDIYKGSYEGMYCTPCESFWTESQLVDGKCPDCGREVKPAKEEAYFFKMSKYANKLIEHINTHPEFIQPVSRKNEMMNNFLLPGLQDLCVSRTSFKWGIPVDFDDKHVVYVWLDALTNYITGIGYDADGNSSEQYKKFWPADLHLIGKDIIRFHTIYWPIFLMALGEPLPKQVFGHPWLLQNDGKMSKSKGNVIYADDLVDLFGVDAVRYFVLHEMPFENDGVISWELMVERMNSDLANTLGNLVNRTIAMSNKYFGGVVNKTGVEDAAIDGDLKAVVTATRDKVQAKMATLHVADAITEVFTLFKRCNKYIDETMPWALAKDEAQQDRLAEVLYNLVESITIGANLLKSFMPETTDKILAQLYPANPEAGVRDFDDLATFGLRETGLKVTETPEILFARLDFEKDLKEKVDAIQEAQKKANGVTEYPQVEVKPEITFDDFEKVQFRVAKVLTCEAVKKTKLLKFELQIGDEKRTIVSGIQKYYKPEELIGKKLVVCTNLKPRKICGIESQGMIISAWDDKDNLSVLTLEKDIIEGAEIG
>NC_012778.1|WP_049777967.1|2100406_2102215_+|DUF885-domain-containing-protein
MRNKQLCFLHQFLNKAVSLLIVFIMVITLSGCSLPWNQKQISETTISATEDNADFTDYVNNLFADLLSADMVSLHAYVEHPKDFGINDYEITLGRYDLDNPDDSSDYTDIISTLKSFDRSTLSAKQQITLDELLMYMENALEYSDLYMFNTQLQTTTGIHVQLPLLFAEYTFEEKKDIDEYIELLCDVDGYFENMAAFEKLRADNGYFMEDTLADEVIESCNSFIETAGLEDGAMISTFDEKLASVDGLSSQDIADYKAKNVSAVNEHVIPGYQSLVNALTSLKGSNRYSGGLCNYPEGSRYFEYILSSTLGWSKSVDEYDKLVDSYIKKYMLKMQSLALKDSSILDKFDTFSFNMTDPVGILTDLKKRITDDFPEIPDVNYNIKYVSKALEDYTSPAMYFIPQLDNLDINSIYINSSGTSASELYPTLAHEGYPGHMYQTQYFAATNPDWIRYILAPGGYVEGWASYVEVLSYNYAQTGNDALNKMYAANYATVLCLYAKGDIGVNYYGWSEDDVYRFISQYGFDDKSVAHEMYYAFVSDPGNYCKYVLGMLGFEQLKTKAQSELSDKFNLKNFHQYILDMGPVQFDILFNNLDAWIKKEK

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_012778_4	4.1\|2090774\|16\|NC_012778\|PILER-CR	2090774-2090789	16	NC_012778.1	2090898-2090913	0	1.0
NC_012778_4	4.1\|2090774\|16\|NC_012778\|PILER-CR	2090774-2090789	16	NC_012778.1	2091022-2091037	1	0.938
NC_012778_4	4.2\|2090844\|25\|NC_012778\|PILER-CR	2090844-2090868	25	NC_012778.1	2090943-2090967	0	1.0

1. spacer 4.1|2090774|16|NC_012778|PILER-CR matches to position: 2090898-2090913, mismatch: 0, identity: 1.0

gggattggacttccac	CRISPR spacer
gggattggacttccac	Protospacer
****************

2. spacer 4.1|2090774|16|NC_012778|PILER-CR matches to position: 2091022-2091037, mismatch: 1, identity: 0.938

gggattggacttccac	CRISPR spacer
gggattggacttctac	Protospacer
*************.**

3. spacer 4.2|2090844|25|NC_012778|PILER-CR matches to position: 2090943-2090967, mismatch: 0, identity: 1.0

cgtcatgctttggcgctctttttgg	CRISPR spacer
cgtcatgctttggcgctctttttgg	Protospacer
*************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_012778_2	2.5\|1467966\|29\|NC_012778\|CRISPRCasFinder,CRT,PILER-CR	1467966-1467994	29	NC_011562	Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2 plasmid pCFPG3 DNA, complete sequence	25740-25768	4	0.862
NC_012778_2	2.5\|1467966\|29\|NC_012778\|CRISPRCasFinder,CRT,PILER-CR	1467966-1467994	29	NC_011564	Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2 plasmid pCFPG1 DNA, complete sequence	26670-26698	4	0.862
NC_012778_2	2.4\|1467903\|27\|NC_012778\|CRISPRCasFinder,CRT,PILER-CR	1467903-1467929	27	MT787017	UNVERIFIED: Staphylococcus phage WV, complete genome	63220-63246	5	0.815
NC_012778_2	2.4\|1467903\|27\|NC_012778\|CRISPRCasFinder,CRT,PILER-CR	1467903-1467929	27	MF417908	Uncultured Caudovirales phage clone 10S_1, partial genome	17447-17473	5	0.815
NC_012778_2	2.4\|1467903\|27\|NC_012778\|CRISPRCasFinder,CRT,PILER-CR	1467903-1467929	27	KY794643	Staphylococcus phage vB_Sau_S24, complete genome	39194-39220	5	0.815
NC_012778_2	2.4\|1467903\|27\|NC_012778\|CRISPRCasFinder,CRT,PILER-CR	1467903-1467929	27	LR215721	Staphylococcus phage Stab22 genome assembly, chromosome: I	82253-82279	5	0.815
NC_012778_2	2.4\|1467903\|27\|NC_012778\|CRISPRCasFinder,CRT,PILER-CR	1467903-1467929	27	LR215720	Staphylococcus phage Stab23 genome assembly, chromosome: I	79558-79584	5	0.815
NC_012778_2	2.4\|1467903\|27\|NC_012778\|CRISPRCasFinder,CRT,PILER-CR	1467903-1467929	27	KY794642	Staphylococcus phage vB_Sau_Clo6, complete genome	39155-39181	5	0.815
NC_012778_2	2.4\|1467903\|27\|NC_012778\|CRISPRCasFinder,CRT,PILER-CR	1467903-1467929	27	LC168164	Tenacibaculum phage pT24 DNA, complete genome	6223-6249	6	0.778
NC_012778_2	2.5\|1467966\|29\|NC_012778\|CRISPRCasFinder,CRT,PILER-CR	1467966-1467994	29	AP014353	Uncultured Mediterranean phage uvMED isolate uvMED-GF-U-MedDCM-OCT-S39-C37, * SEQUENCING IN PROGRESS *	4656-4684	6	0.793
NC_012778_2	2.5\|1467966\|29\|NC_012778\|CRISPRCasFinder,CRT,PILER-CR	1467966-1467994	29	CP035920	Vibrio cidicii strain 2423-01 plasmid unnamed1, complete sequence	49-77	7	0.759

1. spacer 2.5|1467966|29|NC_012778|CRISPRCasFinder,CRT,PILER-CR matches to NC_011562 (Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2 plasmid pCFPG3 DNA, complete sequence) position: , mismatch: 4, identity: 0.862

ataaaccaatgagaaaattacttgg-atat	CRISPR spacer
ttaaacgaatgagaaaaatacttggcata-	Protospacer
 ***** ********** ******* ***

2. spacer 2.5|1467966|29|NC_012778|CRISPRCasFinder,CRT,PILER-CR matches to NC_011564 (Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2 plasmid pCFPG1 DNA, complete sequence) position: , mismatch: 4, identity: 0.862

ataaaccaatgagaaaattacttgg-atat	CRISPR spacer
ttaaacgaatgagaaaaatacttggcata-	Protospacer
 ***** ********** ******* ***

3. spacer 2.4|1467903|27|NC_012778|CRISPRCasFinder,CRT,PILER-CR matches to MT787017 (UNVERIFIED: Staphylococcus phage WV, complete genome) position: , mismatch: 5, identity: 0.815

aaattataaagtaacaacacaagtaaa	CRISPR spacer
agattatgaagtaacaacacaaggtga	Protospacer
*.*****.***************  .*

4. spacer 2.4|1467903|27|NC_012778|CRISPRCasFinder,CRT,PILER-CR matches to MF417908 (Uncultured Caudovirales phage clone 10S_1, partial genome) position: , mismatch: 5, identity: 0.815

aaattataaagtaacaacacaagtaaa	CRISPR spacer
aagttataaagtaacaacaaaagaacc	Protospacer
**.**************** *** *

5. spacer 2.4|1467903|27|NC_012778|CRISPRCasFinder,CRT,PILER-CR matches to KY794643 (Staphylococcus phage vB_Sau_S24, complete genome) position: , mismatch: 5, identity: 0.815

aaattataaagtaacaacacaagtaaa	CRISPR spacer
agattatgaagtaacaacacaaggtga	Protospacer
*.*****.***************  .*

6. spacer 2.4|1467903|27|NC_012778|CRISPRCasFinder,CRT,PILER-CR matches to LR215721 (Staphylococcus phage Stab22 genome assembly, chromosome: I) position: , mismatch: 5, identity: 0.815

aaattataaagtaacaacacaagtaaa	CRISPR spacer
agattatgaagtaacaacacaaggtga	Protospacer
*.*****.***************  .*

7. spacer 2.4|1467903|27|NC_012778|CRISPRCasFinder,CRT,PILER-CR matches to LR215720 (Staphylococcus phage Stab23 genome assembly, chromosome: I) position: , mismatch: 5, identity: 0.815

aaattataaagtaacaacacaagtaaa	CRISPR spacer
agattatgaagtaacaacacaaggtga	Protospacer
*.*****.***************  .*

8. spacer 2.4|1467903|27|NC_012778|CRISPRCasFinder,CRT,PILER-CR matches to KY794642 (Staphylococcus phage vB_Sau_Clo6, complete genome) position: , mismatch: 5, identity: 0.815

aaattataaagtaacaacacaagtaaa	CRISPR spacer
agattatgaagtaacaacacaaggtga	Protospacer
*.*****.***************  .*

9. spacer 2.4|1467903|27|NC_012778|CRISPRCasFinder,CRT,PILER-CR matches to LC168164 (Tenacibaculum phage pT24 DNA, complete genome) position: , mismatch: 6, identity: 0.778

aaattataaagtaacaacacaagtaaa	CRISPR spacer
tatgaataaagtaacaacaaaagtaat	Protospacer
 *   ************** ******

10. spacer 2.5|1467966|29|NC_012778|CRISPRCasFinder,CRT,PILER-CR matches to AP014353 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-U-MedDCM-OCT-S39-C37, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 6, identity: 0.793

ataaaccaatgagaaaattacttggatat	CRISPR spacer
atcaaccaatgagtaaattacttaaagaa	Protospacer
** ********** *********..* *

11. spacer 2.5|1467966|29|NC_012778|CRISPRCasFinder,CRT,PILER-CR matches to CP035920 (Vibrio cidicii strain 2423-01 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.759

ataaaccaatgagaaaattacttggatat	CRISPR spacer
acttattgatgagaaaattactttgatat	Protospacer
*.  *...*************** *****

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NC_012780

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CRISPR-Cas detection and classification

Crispr_ID: NC_012780_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_012780_1

230533-230626

Orphan

Consensus_repeat	Method
GCTCTGGTGCGTCGGTTTGGACTTTTCAAGTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_012780_1

>merge|NC_012780|1|230533-230626|CRISPRCasFinder
GCTCTGGTGCGTCGGTTTGGACTTTTCAAGTCCTGTTTCTGCTTCTAACGTCCAATCTGCTCGCTCTGGTGCGTCGGTTTGGACTTTCCAAGTC

>NC_012780|1|1|230533-230626|CRISPRCasFinder
GCTCTGGTGCGTCGGTTTGGACTTTTCAAGTC	CTGTTTCTGCTTCTAACGTCCAATCTGCTC
GCTCTGGTGCGTCGGTTTGGACTTTCCAAGTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_012780.1\|WP_012740547.1\|222352_223342_-\|phosphate-acyltransferase-PlsX	unknown	unknown	gnl\|CDD\|235414
NC_012780.1\|WP_012740560.1\|235454_237173_-\|MCP-four-helix-bundle-domain-containing-protein	unknown	unknown	gnl\|CDD\|214599
NC_012780.1\|WP_012740559.1\|233716_235408_-\|GGDEF-and-EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|238923
NC_012780.1\|WP_012740564.1\|241412_241847_-\|hypothetical-protein	unknown	unknown	unknown
NC_012780.1\|WP_012740552.1\|226765_227224_-\|3-hydroxyacyl-ACP-dehydratase-FabZ	unknown	unknown	gnl\|CDD\|234568
NC_012780.1\|WP_012740550.1\|225058_225829_-\|acetyl-CoA-carboxylase-carboxyl-transferase-subunit-beta	unknown	unknown	gnl\|CDD\|235547
NC_012780.1\|WP_012740562.1\|238808_239963_-\|amino-acid-permease	unknown	unknown	gnl\|CDD\|223884
NC_012780.1\|WP_012740546.1\|221556_222330_-\|arginase-family-protein	unknown	unknown	gnl\|CDD\|273514
NC_012780.1\|WP_012740553.1\|227220_227952_-\|3-oxoacyl-ACP-reductase-FabG	unknown	unknown	gnl\|CDD\|235500
NC_012780.1\|WP_041688922.1\|228015_230409_-\|beta-ketoacyl-[acyl-carrier-protein]-synthase-family-protein	unknown	unknown	gnl\|CDD\|238430
NC_012780.1\|WP_148231392.1\|233032_233641_+\|zinc-dependent-phospholipase-C-family-protein	unknown	unknown	gnl\|CDD\|376406
NC_012780.1\|WP_012740556.1\|231365_232256_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223730
NC_012780.1\|WP_012740548.1\|223398_224121_-\|flavodoxin-family-protein	unknown	unknown	gnl\|CDD\|223728
NC_012780.1\|WP_165437556.1\|232273_232807_-\|TetR/AcrR-family-transcriptional-regulator-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|274100
NC_012780.1\|WP_012740549.1\|224113_225022_-\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha	unknown	unknown	gnl\|CDD\|235580
NC_012780.1\|WP_012740545.1\|220866_221307_-\|Hsp20/alpha-crystallin-family-protein	unknown	unknown	gnl\|CDD\|107228
NC_012780.1\|WP_041688923.1\|240114_241329_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|226925
NC_012780.1\|WP_012740561.1\|237719_238760_-\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|277329
NC_012780.1\|WP_041689069.1\|230865_231111_-\|acyl-carrier-protein	unknown	unknown	gnl\|CDD\|223314
NC_012780.1\|WP_041688921.1\|225831_226761_-\|ACP-S-malonyltransferase	unknown	unknown	gnl\|CDD\|223408

Protein	Function_ID	Function_description	E-value
NC_012780.1\|WP_012740547.1\|222352_223342_-\|phosphate-acyltransferase-PlsX	gnl\|CDD\|235414	PRK05331, PRK05331, phosphate acyltransferase PlsX.	7.08526e-104
NC_012780.1\|WP_012740560.1\|235454_237173_-\|MCP-four-helix-bundle-domain-containing-protein	gnl\|CDD\|214599	smart00283, MA, Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.	2.44004e-39
NC_012780.1\|WP_012740559.1\|233716_235408_-\|GGDEF-and-EAL-domain-containing-protein	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	8.05139e-72
NC_012780.1\|WP_012740552.1\|226765_227224_-\|3-hydroxyacyl-ACP-dehydratase-FabZ	gnl\|CDD\|234568	PRK00006, fabZ, 3-hydroxyacyl-ACP dehydratase FabZ.	3.74544e-52
NC_012780.1\|WP_012740550.1\|225058_225829_-\|acetyl-CoA-carboxylase-carboxyl-transferase-subunit-beta	gnl\|CDD\|235547	PRK05654, PRK05654, acetyl-CoA carboxylase carboxyltransferase subunit beta.	2.50504e-125
NC_012780.1\|WP_012740562.1\|238808_239963_-\|amino-acid-permease	gnl\|CDD\|223884	COG0814, SdaC, Amino acid permeases [Amino acid transport and metabolism].	5.31535e-09
NC_012780.1\|WP_012740546.1\|221556_222330_-\|arginase-family-protein	gnl\|CDD\|273514	TIGR01230, Agmatinase_Agmatine_ureohydrolase_AUH., agmatinase. Members of this family include known and predicted examples of agmatinase (agmatine ureohydrolase). The seed includes members of archaea, for which no definitive agmatinase sequence has yet been made available. However, archaeal sequences are phylogenetically close to the experimentally verified B. subtilis sequence. One species of Halobacterium has been demonstrated in vitro to produce agmatine from arginine, but no putrescine from ornithine, suggesting that arginine decarboxylase and agmatinase, rather than arginase and ornithine decarboxylase, lead from Arg to polyamine biosynthesis. Note: a history of early misannotation of members of this family is detailed in PUBMED:10931887.	8.97711e-06
NC_012780.1\|WP_012740553.1\|227220_227952_-\|3-oxoacyl-ACP-reductase-FabG	gnl\|CDD\|235500	PRK05557, fabG, 3-ketoacyl-(acyl-carrier-protein) reductase; Validated.	7.80235e-103
NC_012780.1\|WP_041688922.1\|228015_230409_-\|beta-ketoacyl-[acyl-carrier-protein]-synthase-family-protein	gnl\|CDD\|238430	cd00834, KAS_I_II, Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP.	1.48002e-129
NC_012780.1\|WP_148231392.1\|233032_233641_+\|zinc-dependent-phospholipase-C-family-protein	gnl\|CDD\|376406	pfam00882, Zn_dep_PLPC, Zinc dependent phospholipase C.	1.05149e-15
NC_012780.1\|WP_012740556.1\|231365_232256_-\|alpha/beta-hydrolase	gnl\|CDD\|223730	COG0657, Aes, Esterase/lipase [Lipid metabolism].	3.0215e-30
NC_012780.1\|WP_012740548.1\|223398_224121_-\|flavodoxin-family-protein	gnl\|CDD\|223728	COG0655, WrbA, Multimeric flavodoxin WrbA [General function prediction only].	9.86143e-27
NC_012780.1\|WP_165437556.1\|232273_232807_-\|TetR/AcrR-family-transcriptional-regulator-C-terminal-domain-containing-protein	gnl\|CDD\|274100	TIGR02366, conserved_hypothetical_protein, probable dihydroxyacetone kinase regulator. The seed alignment for this family was built from a set of closely related uncharacterized proteins associated with operons for the type of bacterial dihydroxyacetone kinase that transfers PEP-derived phosphate from a phosphoprotein, as in phosphotransferase system transport, rather than from ATP. Members have a TetR transcriptional regulator domain (pfam00440) at the N-terminus and sequence homology throughout.	3.62457e-11
NC_012780.1\|WP_012740549.1\|224113_225022_-\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha	gnl\|CDD\|235580	PRK05724, PRK05724, acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated.	1.45454e-139
NC_012780.1\|WP_012740545.1\|220866_221307_-\|Hsp20/alpha-crystallin-family-protein	gnl\|CDD\|107228	cd06471, ACD_LpsHSP_like, Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers consisting of multiple subunits. Transcription of the genes encoding Lp HSP 18.5, 18.55 and 19.3 is regulated by a variety of stresses including heat, cold and ethanol. Early growing L. plantarum cells contain elevated levels of these mRNAs which rapidly fall of as the cells enter stationary phase. Also belonging to this group is Bifidobacterium breve (Bb) HSP20 and Oenococcus oenis (syn. Leuconostoc oenos) (Oo) HSP18. Transcription of the gene encoding BbHSP20 is strongly induced following heat or osmotic shock, and that of the gene encoding OoHSP18 following heat, ethanol or acid shock. OoHSP18 is peripherally associated with the cytoplasmic membrane.	7.18119e-47
NC_012780.1\|WP_041688923.1\|240114_241329_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|226925	COG4552, Eis, Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only].	1.37119e-43
NC_012780.1\|WP_012740561.1\|237719_238760_-\|metallophosphoesterase	gnl\|CDD\|277329	cd07383, MPP_Dcr2, Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain. DCR2 phosphatase (Dosage-dependent Cell Cycle Regulator 2) functions together with DCR1 (Gid8) in a common pathway to accelerate initiation of DNA replication in Saccharomyces cerevisiae. Genetic analysis suggests that DCR1 functions upstream of DCR2. DCR2 interacts with and dephosphorylates Sic1, an inhibitor of mitotic cyclin/cyclin-dependent kinase complexes, which may serve to trigger the initiation of cell division. DCR2 belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	2.76819e-15
NC_012780.1\|WP_041689069.1\|230865_231111_-\|acyl-carrier-protein	gnl\|CDD\|223314	COG0236, AcpP, Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	4.68949e-10
NC_012780.1\|WP_041688921.1\|225831_226761_-\|ACP-S-malonyltransferase	gnl\|CDD\|223408	COG0331, FabD, (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism].	5.93968e-97

>NC_012780.1|WP_041688922.1|228015_230409_-|beta-ketoacyl-[acyl-carrier-protein]-synthase-family-protein
MTENNNRAVITGLGMICAIGNSVDEAWNNAINSVSGIHKTTTLDTTDCYADLAAEVKCDTLGDFEGSEDADRSAQLCIKAAGEAMKDAGLDDFAGDPKASVIIGSCVGGAVSISDYYEHGKKASDVTKMPISSIAPQVAGQCHAGGVVTNIANACAAGTISIAYACELIRAGKADVVLAGGSDTFAAVPYAGFLSLHALDADGCSPFNRCTGITLGEGSGVVVVESYEHAKARNAKMYCEVLGAGVSSDAHHITAPRPDGEGQMEAINRAIKNSGLKKSDIGYVNAHGTGTAKNDDAEFLSLHTIFDGENNNLSVSSTKAMTGHCLGAAGAIEAVFSIKALTTNTVVPTLGFKDEDMDKLAEKAGKIDFCPNKAHEKELTSVMNNSFAFGGNNASIIFSKEAGNVTVKEEKKPLVITGIGVVTPSGNGVDSYVANAVKNEALTEANLRSSVGKEDYDALGLKMSFYRKLDNFSQLQAVSGMEALKDADYAVTDDNATDIGIIVGTSEGALGTCCDFQSMITEKGNASGSAFKFPNTVYNAAGGYLSICSGIKGYNVTVTNGAQSGLASMAYAMSVLRSGQENAMLATGSDENSDIMTELFGKLGVTSEKVVAPFAGNDGFVLSDGSASVLIEDEKAARERGARIYCHAAGYGMAHSNVKFGTLTGSEAGLTNAVNNALADAGMTIDDIDAVFGFANGMKAVDDVEIKGLTAVFGDKLAEKPVVELKEVLGESRAAAATTAAAHAALMFAGKIPSQEAYSIAADGSVSKTNVEASKLNNVLVVAYGAGGSYTAIVLSK
>NC_012780.1|WP_012740553.1|227220_227952_-|3-oxoacyl-ACP-reductase-FabG
MKVALVTGASRGIGKACAIRLAKDGYAVVINYSHSEEQAQKVLDEIVAAGGTAITYKADVSDLNQVKQMVKDVSKELGGIDVLVNNAGIVRDEYLLMLNKDTLDTCMDLNVKGYFYCAQQAVLKMFRKKSGVIINMSSVSSKFALPGQSVYSATKGAVNSMTQTMAKELAGYGIRVNAVAPGFIETEMLDAIPEEKKKEYLDAIPMHKLGKAEDVANVVSSLCSDAFSYVTGQVIVLDGGLSL
>NC_012780.1|WP_012740552.1|226765_227224_-|3-hydroxyacyl-ACP-dehydratase-FabZ
MMNIFEINKRIGQRPPFQMIEKVLELEPNVSARGIKNVSINEPYFMGHFPDAPIMPGVLIIESCAQLCSLVIDDGGKSREEGKLYVLLKVDGFKFVKPVIPGDTLDITVTATRINKVLASFDAVVKVDGNVYAKGSMTFTTVDRKDIYGTEE
>NC_012780.1|WP_041688921.1|225831_226761_-|ACP-S-malonyltransferase
MGKIAVLFSGQGAQYVGMGKDLYDSDSDAKKLYDLGESLRPGTVKVCFEGEGEELTKTENTQPALFLTDLAFANALKDAGIKADAVAGFSLGEIPALAYAGVLSIEDAFKLVVIRGTKMGELSTKYAGGMAAALKLAPEVVEETCKEFKEIWPVNYNCPGQISCAGSAEEIDAFCEAIKEKGGRAVKLAVSGAFHTPYMKDASEELEKALKVMTINAPQTEIYANRTGKPYPQDTAQIIETIALQASSSVRFEDTLKNMWADGIDTFIEVGAGKTLTGFVKKTLPEAKMYTVTTVDALNETIENIKAGE
>NC_012780.1|WP_012740550.1|225058_225829_-|acetyl-CoA-carboxylase-carboxyl-transferase-subunit-beta
MTVKCNKCKEEINKEDLEKNYYICPLCGKLNRMPAKNRLQMLTEKFDVMFNDQEFTDPIDFPSYKEKYESAREKSGETEGVVCGRGTIGGNDTCIFIMEPNFMMGSMGTVVGDRITALFEYATKNRLPVIGYTVSGGARMQEGALSLMQMAKVSAAAKRHSDAGLLYVVCTTDPTMGGATASFAMLGDIIISEPGAMIGFAGKRVVEQVTGEVLPDNFQSAEFQLKNGFIDDIVPRQEQRAYLANILAIHAETVSA
>NC_012780.1|WP_012740549.1|224113_225022_-|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha
MTNENLSVYDRICRTRKSGRATASDYINATITDFVELHGDRCFADDHAIVGGIGRLNGKPVTVIGIEKGRDLNERLLRNFGCVLPEGYRKALRLIKQAEKFHRPVICFVDTQGANCGKGAEERGQGQAIANNLYELTDVKTPIISVMIGEGGSGGALALAVADEVWMLENAYYSVITPESCASILFKDPKRAPEAAEHLKLTASDLNKMGIVEKVVEEPEDFSEEKETSHFMKKLADDLSKEIKQLEKKPVDKLLDDRYEKYRKIGRYSEYSEAVGEVPGAAQLLGVSQAPARKRRGLFGRG
>NC_012780.1|WP_012740548.1|223398_224121_-|flavodoxin-family-protein
MAKILVLNGSPHKSASTTMAVTNAFVKGMCEGGEYESEIITISDLNVTPCMGCLSCWARTEGECVIKNDDMPAVKKRIEEADIIIESYPLYFFGMPGQMKLFTDRLLSMMCTYRGQKPPENGESFHGIRNPKTGQKLVLISGCAYSESESVYDSLLKEYECICGKNGFTAILCPQLKTLIELGASSRLDRYLSKYEAAGKEFAATKHLSEETKQKLSKAPFSEAVYKNLLDNFWREQKEG
>NC_012780.1|WP_012740547.1|222352_223342_-|phosphate-acyltransferase-PlsX
MIKIVVDLLGADKPQTELVLGAIRAISENKDLYVYLMGRKTELEDFLANVTYDESQLEIVDCTQEITNYDDPVDAYHDKTDSSLIKGLKMCRMNEDIGGFVTCGATGVVLISSILILGKLNATRPALSVVLNGRNDKPFCIVDCGANIDCKADRFVDFARLGVAYMKTLGIENPTVATLSNGIEAGKGSDVIKEAHELLEKCGFNFTGNIEGKEVLDGNADVVVCDGFAGNVLLKSIEGTAKVVFDDIRRAAAGASDTQKAQLEAFIGRLEPKFDYNNEGGAILLGVKKPVVKGHGAATDKTVYNTVKIAYGLAKNNLVEKISEEFEKK
>NC_012780.1|WP_012740546.1|221556_222330_-|arginase-family-protein
MQREKNNNFILDFTGVYDDEFAKEKTSLTWIDCTDITGCDMYVSDEAEKQIGERVDSVGIHGIHFIDSGNYHYVTKIMTDRIKEPFSLVVFDHHTDMQKPMIEGLTSCGDWAGKVIKDNPYICQLILVGPEKKDINAIGLRSNKLITYSAQEIRAEAMESKTNQIDLSVPVYISIDKDVLDESISETNWSQGHMKLGTLEHILGIIIRNQKVLGIDICGECDTNMPLPEYMEDEEKNGELNKELYNFLLKRLKKYSL
>NC_012780.1|WP_012740545.1|220866_221307_-|Hsp20/alpha-crystallin-family-protein
MLMPSIFGENLFNDDWMDFGFPEVDKALYGKHANNVMKTDVKETDTGYEVDIDLPGFKKDEINAQLDNGYLTISAAKGLDKDEKDKKGKYIRKERYAGAMSRSFYVGEGVTQEDIKAKYEDGILRLSVPKKEAKAVENKKYIAIEG
>NC_012780.1|WP_041689069.1|230865_231111_-|acyl-carrier-protein
MSTNEIMPKLKDFLCENLGIDADVLEFDTQLFGDGEIGLDSIDSLEIIAYVDDEFGVQMTGVGKEHFYSIETIAKYIEENA
>NC_012780.1|WP_012740556.1|231365_232256_-|alpha/beta-hydrolase
MGNILTKQFYRQRKDFEDSCAGRDAGLTFPEGVRCSTDIAYADDGIKAHMLDIYRPEDSQEKILPVIINVHGGGLIIGNKEFNRYFCALLCKKGFLVYSIEYRLIPDCLIYDQLADVFMAMDYIKERLAADGGDSSHVYMAGDSGGACLITYANAIQNSTNIARAANVTPSGLRINALGLISGMFYTSRFDKIGLFLPKYLYGRDYKKTSFAKYVNPENRELLNSLAPVWLVTSHNDFLRRYTTDFEKALTRAEREHELVDFPKNKKLTHAFSVFEPFLPESSAVIDMMVEYLRKF
>NC_012780.1|WP_165437556.1|232273_232807_-|TetR/AcrR-family-transcriptional-regulator-C-terminal-domain-containing-protein
MKCTLELAEKKSLKKITVKDIADECGITRSTFYYHFSDIYDVLDGVVQAKIDEFNEEYNGEMDKVLMRFIEYSIIHRKVWANLFDARGREWLEKYVKTRIHYLALLQIRKMSEGYILSIRDVEIICSFYEEAIFGLLIRWIIKEEKAKTVDEIKDTVERIEKLFEGQLDLIISNMKK
>NC_012780.1|WP_148231392.1|233032_233641_+|zinc-dependent-phospholipase-C-family-protein
MKGKLMNKYGHVTVTKRLTPMLKKRHDFALRLGSIMPDILLHTYIKGHTWDSSYNKVSRRLQRLERHGRMNCFSFLSLGYALHYIEDYFTFPHNSWYPEPMSEHVLYEIKFMNYIRENKNDINKPLISNNGRGVSADRMLDYLITNHKKYAANEQGFDNDYSFITSVGYAFVTNYVKLFMINSGKDIVIDMNEDYVALNSNI
>NC_012780.1|WP_012740559.1|233716_235408_-|GGDEF-and-EAL-domain-containing-protein
MINDIFKLFGEKAADILFEIITECMDDYLYIFDLQNNTFEISQSAVERFNIPSNILTDMSNEVMNVVYEEDREMLAKHLADICEGREMVHNLHYRWLDKEGMPVWINSRGIVVNDQQGNAEYLVGCLNETGNKRRADNVTGLLGGPEFLAYLRAQKEPITKGFFMHIGIDDFGAINSSRGADYGNYILKSVAGCMKECLSDKQRIYHLVADQYVIVDLEASSAEEAVALKEKITDKLHNFIVDENYEAIFSISIGVIDAATFCEGTEECRKKFEFALKQAKSMGKNGFYIFDQDDYEVFLQQGRIIATLRNAIVNHYDGFEVYYQPIVDCQSEQIIGAEALMRFSMITEEGREFVSPVEFIPLLEETGLIIPAGRYILNEAAAMCCEMQKYIPDFRMNVNVSYVQILQGNVERDILDAIQKYSLQPECLCVEMTESGFMDMTPSFCKFRKTLDKNGIPFVIDDFGTGYSNLHCIRDMNPSYVKMDRDFTDKAMNSDRDYELYKNIITMVHSINVRICAEGIEEKEWLLKMKEMKVDYLQGYYLGRPCGKKQFLQQYASGINIK
>NC_012780.1|WP_012740560.1|235454_237173_-|MCP-four-helix-bundle-domain-containing-protein
MEKIKKRIANLKVAGKLKVYRMTVLVMTLFLVLVALISTLVIRSNIEKITEVWSPSLEYLQDLETMTAKYRIKQYQHLVESDAAVMNSCEEEIQKLESQIQDTCAKLNAIITADSDAQKGQADYEAASTGWEKYRAASDEILQLSRENKQQEAARLMIGEAYEEYNAFAEKLTILSDEFQIELDQAKTMANVCTIIIFVVIVAAGLAIAVVTTLIGKIITNSITEPVEQIDAAVASLRKGELSNVEMLTYESEDELGDTIKNLKEAMGILADYVSEISVEVKAIAQGDLTRNGDDITDFLGDFSELKTSLLYILKRFNSTLTEIRNLAEQVSSNASEVENASKSLADGATEQAGVIEELNATIDTVVDLAADTAKETQSASARVKASADKANEEKEKMNDLLMEMEHITEISKEIGNIITDIEDIASQTNLLSLNASIEAARAGEAGKGFAVVADQIGKLAADSAKSAVNTRDLIDKTLVEIENGNTITRTTADAFNQIIADMESFAEIAQNTMEKANSQAESLEQIGQGIEQLSGVVQGNAASSEENTAISINLAEGAAKMHDRVNIFKLF
>NC_012780.1|WP_012740561.1|237719_238760_-|metallophosphoesterase
MYKSDNLKQTDNETFTYKIDKNKDFKILQLTDLHLGFGFISRKKDKMALNAVTKIIHKAKPDMIVLTGDSIFPFLPKVGTLNNRKQAYKLMKFMDSFAIPYTLVFGNHDCEMGSTCNKEELAQIYKKGKYCIFTEGRKELTGVGNFFINLTDSDGNAILPLVMLDSNMYGEGGWFYSGFDRIHDDQVEWCMNRLNDLKKCNPDIKAMAFFHMPPAEFKEAYRKMKLGDKSVIYQHGSIAEKNEHFGISKFEGTFFNKAVENGVIKWMFCGHDHLNTLSLIYKGIQMTYGMSIDYLGYKDIDKSYIQRGGTLITRKADGQVTVNMVPLGAVVSTRVRGVNTPQNDEK
>NC_012780.1|WP_012740562.1|238808_239963_-|amino-acid-permease
MSIKSEAKLTTFEAISMIVGNSIGTGIIAVPYLATKNSMLDVIWMVGAAYVINVILHLIIAELSYNNGGVQLVKSFEGELFHGVMKKVFSWIVFVVYGLAIMIGVSGNINGGAQIFVNWFGLPLWLAQVIYYVIAGIVVFMGMKAVGIAQKYAVILLMGIVAVMTVGTFTHPVNGFYTAPFHWNNLLALYSMVVFATSANQAVIQVVKGLDGNPGKIRKSIFIGFGLSSAFVLVVTLTVLLGTKGTIDKELAYMQLGESIGKWAVILAGIFSLFALLTTFWSNTLALRDVVHEQVGIGNRVSWLIATVPCILFAIFGVSSFIILTRIMSGVVVLVSIMLVLTYGKSRKKAGASPICGVIGTLPFQILMVVSTIVSAIGALIPLS
>NC_012780.1|WP_041688923.1|240114_241329_+|GNAT-family-N-acetyltransferase
MSRNDENNYTLRPLTIDDAEEYNALLRYAFQVTEQELAETGWKDDEITQSKFPVLQRADVLGCFNGDDLIAQFAVYPLDMNIYGMKYSVGFVTSVCTYPEYTGHGIMKRLMIQSLIRMRDAHKSFALLYPYSIPLYRGLGWEIISNKMTYTIKDTQIPRKLNEPGYVRRVSWDDKEFKELHTKFAEKTHGCLYRNNLAWEEYWRWDEDDTSVAIYYSKDDVPYGYMVYMISSDVMHVKEMIYLNREAQLGLWEFIHAHDSMIDEVRGNNYYSEPIAFELDDSDIKETIRPYTMGRIIDIRQFFAKYACDPDEPSVCIRFYIEDDLLAWNNGYFTYLFDNGRCIETEQQPDYEVSMSIGTLTTLMLGYKTAEKLHIMDKIQASDEAIEHLDDILFHRIPYVSDYI
>NC_012780.1|WP_012740564.1|241412_241847_-|hypothetical-protein
MTFVNKVRYKTAAEREDVKLAVLEAMDECIEENILVDFFEQHREEVVEVSIYDYDEEKVRKTLVDEAVEEIVVKVVDEAKKETTQLNMINLIIKKVKKEKTLETIASELEENVEDIKVLYDIVIEAAPEYDVDKIMKKLNNEND

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_012780_1	1.1\|230565\|30\|NC_012780\|CRISPRCasFinder	230565-230594	30	NZ_CP040345	Bacillus albus strain DLOU-Yingkou plasmid unnamed1, complete sequence	286369-286398	7	0.767

1. spacer 1.1|230565|30|NC_012780|CRISPRCasFinder matches to NZ_CP040345 (Bacillus albus strain DLOU-Yingkou plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.767

ctgtttctgcttctaacgtccaatctgctc-----	CRISPR spacer
cagtttctgcttctaaagtcca-----ctcatgag	Protospacer
* ************** *****     ***

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

112643 : 116547

uncultured_phage(33.33%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012740415.1\|112643_113126_-	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	E7DN65	Pneumococcus_phage	1.3e-51	71.4
WP_012740416.1\|113141_113825_-	7-cyano-7-deazaguanine synthase QueC	A0A1U9WRB5	Streptococcus_virus	1.8e-59	54.7
WP_041689039.1\|113837_114410_-	GTP cyclohydrolase I FolE	S4U0J3	uncultured_phage	2.0e-48	56.0
WP_012740418.1\|114497_115163_-	putative 7-carboxy-7-deazaguanine synthase QueE	S4TZT1	uncultured_phage	3.4e-39	43.3
WP_012740419.1\|115178_115598_-	6-carboxytetrahydropterin synthase QueD	J9PV91	Bacillus_phage	1.8e-09	29.9
WP_012740420.1\|116028_116547_-	O-acetyl-ADP-ribose deacetylase	F1SVT2	Red_sea_bream_iridovirus	8.6e-38	48.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

3. NC_012782

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

2923 : 34703

unidentified_phage(18.18%)

plate,head,capsid,tail,holin,terminase,portal

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012744423.1\|2923_3187_-\|holin	phage holin family protein	A0A142F1N6	Bacillus_phage	1.1e-20	57.5
WP_041688876.1\|3265_3580_-	hypothetical protein	NA	NA	NA	NA
WP_012744426.1\|3942_4236_-	hypothetical protein	NA	NA	NA	NA
WP_041688877.1\|4183_5434_-	RNA-directed DNA polymerase	H7BVF9	unidentified_phage	7.5e-120	52.4
WP_012744428.1\|5939_7745_-\|tail	phage tail protein	H7BVG0	unidentified_phage	6.7e-146	49.0
WP_148231379.1\|7764_8604_-	DUF2313 domain-containing protein	H7BVG1	unidentified_phage	3.0e-24	39.3
WP_012744430.1\|8629_9694_-\|plate	baseplate J/gp47 family protein	A0A0A8WJT7	Clostridium_phage	2.9e-88	50.4
WP_012744431.1\|9686_10103_-	DUF2634 domain-containing protein	A0A0A8WJ32	Clostridium_phage	1.3e-12	32.1
WP_012744432.1\|10103_10520_-	DUF2577 domain-containing protein	NA	NA	NA	NA
WP_041688878.1\|10521_11475_-	hypothetical protein	A0A0A7RWY4	Clostridium_phage	1.6e-37	32.0
WP_012744434.1\|11488_12115_-	LysM peptidoglycan-binding domain-containing protein	A0A1V0DZX0	Clostridioides_phage	7.0e-34	36.3
WP_012744435.1\|12133_15304_-	hypothetical protein	Q9F4J3	Streptococcus_phage	6.4e-75	60.9
WP_012744437.1\|15518_15998_-	hypothetical protein	A0A1V0DZX5	Clostridioides_phage	5.7e-12	32.9
WP_012744438.1\|16077_16512_-\|tail	phage tail tube protein	A0A1V0DZX1	Clostridioides_phage	4.5e-32	47.5
WP_012744439.1\|16526_17630_-\|tail	phage tail sheath subtilisin-like domain-containing protein	A0A0A8WJR2	Clostridium_phage	2.2e-59	41.0
WP_012744440.1\|17643_18120_-	hypothetical protein	NA	NA	NA	NA
WP_148231376.1\|18116_18596_-	HK97 gp10 family phage protein	NA	NA	NA	NA
WP_012744442.1\|18592_18940_-	hypothetical protein	NA	NA	NA	NA
WP_012744443.1\|18943_19342_-\|head,tail	phage head-tail connector protein	NA	NA	NA	NA
WP_012744444.1\|19355_19661_-	hypothetical protein	NA	NA	NA	NA
WP_012744445.1\|19685_20600_-	DUF5309 domain-containing protein	A0A2P1CGV3	Mycobacterium_phage	6.9e-14	28.0
WP_012744446.1\|20644_21313_-	hypothetical protein	NA	NA	NA	NA
WP_012744447.1\|21523_21730_-	hypothetical protein	NA	NA	NA	NA
WP_012744448.1\|21729_23709_-\|capsid	minor capsid protein	H7BWE7	unidentified_phage	1.8e-19	26.9
WP_012744449.1\|23743_25303_-\|portal	phage portal protein	A0A0S2MVB2	Bacillus_phage	1.5e-56	32.2
WP_012744450.1\|25363_26854_-\|terminase	phage terminase large subunit	A0A2P9FIL0	Pseudomonas_phage	1.6e-15	28.3
WP_012744451.1\|26904_27093_-	hypothetical protein	NA	NA	NA	NA
WP_012744452.1\|27086_27251_-	hypothetical protein	NA	NA	NA	NA
WP_012744453.1\|27243_27792_-	hypothetical protein	A0A1J1J9Q7	Escherichia_phage	1.2e-16	44.0
WP_012744455.1\|27983_28628_-	FAD-dependent thymidylate synthase	A0A2K9V392	Faecalibacterium_phage	4.8e-54	53.3
WP_012744456.1\|28640_29144_-	DUF3310 domain-containing protein	F4YCQ0	Synechococcus_phage	6.2e-09	47.8
WP_148231380.1\|29299_29758_-	hypothetical protein	A0A218KCF1	Bacillus_phage	1.0e-10	28.0
WP_012744458.1\|30068_30404_-	hypothetical protein	NA	NA	NA	NA
WP_012744459.1\|30379_30967_-	ParB N-terminal domain-containing protein	B5SP22	Lactococcus_phage	3.8e-26	40.4
WP_012744460.1\|31059_31299_-	hypothetical protein	NA	NA	NA	NA
WP_012744461.1\|31291_31543_-	hypothetical protein	NA	NA	NA	NA
WP_148231377.1\|31543_31948_-	hypothetical protein	NA	NA	NA	NA
WP_012744463.1\|31892_32129_-	hypothetical protein	NA	NA	NA	NA
WP_012744464.1\|32197_32968_-	transglycosylase SLT domain-containing protein	NA	NA	NA	NA
WP_012744465.1\|32948_33263_-	hypothetical protein	NA	NA	NA	NA
WP_012744466.1\|33377_34703_-	hypothetical protein	A0A0U3TGV3	Pseudomonas_phage	1.6e-19	43.7

DBSCAN-SWA_2

40638 : 60376

Clostridium_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012744484.1\|40638_41649_-	recombinase RecA	I1TJY4	Clostridium_phage	1.1e-78	45.3
WP_148231378.1\|41632_42058_-	nucleoside triphosphate pyrophosphohydrolase family protein	Q94MU3	Myxococcus_phage	8.1e-18	54.1
WP_165437549.1\|42059_42200_-	hypothetical protein	NA	NA	NA	NA
WP_012744486.1\|42199_42445_-	hypothetical protein	NA	NA	NA	NA
WP_012744487.1\|42425_42668_-	sporulation transcriptional regulator SpoIIID	NA	NA	NA	NA
WP_012744488.1\|42672_43224_-	hypothetical protein	NA	NA	NA	NA
WP_012744489.1\|43207_43393_-	hypothetical protein	NA	NA	NA	NA
WP_012744490.1\|43389_43863_-	Holliday junction resolvase RecU	E7DN76	Pneumococcus_phage	3.1e-10	30.1
WP_012744491.1\|43852_44911_-	hypothetical protein	I1TJX9	Clostridium_phage	3.7e-51	42.0
WP_012744492.1\|44910_45060_-	hypothetical protein	NA	NA	NA	NA
WP_041688884.1\|45158_45698_-	adenine methyltransferase	A0A1B1IT99	uncultured_Mediterranean_phage	1.5e-56	55.4
WP_012744494.1\|45777_46170_-	DUF4406 domain-containing protein	A0A222YYT7	Escherichia_phage	1.8e-11	42.0
WP_012744495.1\|46166_46325_-	hypothetical protein	NA	NA	NA	NA
WP_012744496.1\|46314_46551_-	hypothetical protein	NA	NA	NA	NA
WP_012744497.1\|46565_46874_-	LysM peptidoglycan-binding domain-containing protein	NA	NA	NA	NA
WP_012744498.1\|46860_47292_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_012744499.1\|47297_49472_-	DNA polymerase I	I1TJX8	Clostridium_phage	1.4e-161	44.2
WP_012744500.1\|49679_50312_-	hypothetical protein	E7DND4	Pneumococcus_phage	8.9e-21	31.9
WP_015517536.1\|50355_50514_-	hypothetical protein	NA	NA	NA	NA
WP_012744502.1\|50571_51180_-	sigma-70 family RNA polymerase sigma factor	A0A2I7SA32	Vibrio_phage	1.7e-05	35.0
WP_012744503.1\|51194_52220_-	toprim domain-containing protein	E7DND2	Pneumococcus_phage	6.0e-43	31.5
WP_012744504.1\|52216_52603_-	hypothetical protein	NA	NA	NA	NA
WP_012744505.1\|52862_53240_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_012744506.1\|53285_53726_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_012744507.1\|53745_54009_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_041688879.1\|54008_54476_-	Rha family transcriptional regulator	Q4ZC33	Staphylococcus_virus	9.9e-09	39.8
WP_012744509.1\|54548_54770_-	hypothetical protein	NA	NA	NA	NA
WP_012744510.1\|54759_56106_-	DNA helicase	D9ZNG4	Clostridium_phage	8.4e-85	41.2
WP_012744511.1\|56098_56770_-	ATP-binding protein	I1TJZ3	Clostridium_phage	3.7e-25	42.0
WP_012744512.1\|56850_57612_-	helix-turn-helix domain-containing protein	A0A218M7A2	Flavobacterium_phage	9.1e-12	37.5
WP_012744513.1\|57663_57876_-	hypothetical protein	NA	NA	NA	NA
WP_012744515.1\|57995_58304_-	hypothetical protein	NA	NA	NA	NA
WP_012744516.1\|58428_58656_-	MerR family transcriptional regulator	NA	NA	NA	NA
WP_012744517.1\|58696_60376_-	DEAD/DEAH box helicase	G3MAX4	Bacillus_virus	1.8e-113	45.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_012778

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NC_012780

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

3. NC_012782

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection