CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_014494	Streptococcus pneumoniae AP200, complete sequence	2 crisprs	DEDDh,cas3,DinG	0	0	9	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_014494_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014494_1

135151-135246

Orphan

Consensus_repeat	Method
AATGTGTAAGATTTTTATATATAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014494_1

>merge|NC_014494|1|135151-135246|CRISPRCasFinder
AATGTGTAAGATTTTTATATATAATTTTTCTACACATACATTGTACATCTAAAAGAAAGCCCTGTCAAGAGAAATGTGTAAAATTTTTATATATAA

>NC_014494|1|1|135151-135246|CRISPRCasFinder
AATGTGTAAGATTTTTATATATAA	TTTTTCTACACATACATTGTACATCTAAAAGAAAGCCCTGTCAAGAGA
AATGTGTAAAATTTTTATATATAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_014494.1\|WP_000500038.1\|140458_141331_-\|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-alpha	unknown	unknown	gnl\|CDD\|129801
NC_014494.1\|WP_000273863.1\|134806_135133_-\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NC_014494.1\|WP_001233690.1\|133322_134234_-\|DUF4097-domain-containing-protein	unknown	unknown	gnl\|CDD\|372574
NC_014494.1\|WP_000744897.1\|135271_136438_-\|CynX/NimT-family-MFS-transporter	unknown	unknown	gnl\|CDD\|225365
NC_014494.1\|WP_000200890.1\|139804_140437_-\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|319798
NC_014494.1\|WP_000096192.1\|136495_137656_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133016
NC_014494.1\|WP_000724267.1\|143981_146090_+\|bacteriocin-associated-integral-membrane-family-protein	unknown	unknown	gnl\|CDD\|273736
NC_014494.1\|WP_001035702.1\|137694_139545_+\|polysaccharide-biosynthesis-protein	unknown	unknown	gnl\|CDD\|224011
NC_014494.1\|WP_001075100.1\|127381_128305_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_014494.1\|WP_001189291.1\|142891_143212_-\|hypothetical-protein	unknown	unknown	unknown
NC_014494.1\|WP_001140363.1\|131263_132115_+\|DUF4299-domain-containing-protein	unknown	unknown	gnl\|CDD\|339103
NC_014494.1\|WP_000198687.1\|134226_134820_-\|DUF1700-domain-containing-protein	unknown	unknown	gnl\|CDD\|227053
NC_014494.1\|WP_001230165.1\|143642_143930_+\|lactococcin-972-family-bacteriocin	unknown	unknown	gnl\|CDD\|273735
NC_014494.1\|WP_001030032.1\|130155_131142_+\|rhodanese-related-sulfurtransferase	unknown	unknown	gnl\|CDD\|234663
NC_014494.1\|WP_000838912.1\|141339_142011_-\|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-beta	unknown	unknown	gnl\|CDD\|224674
NC_014494.1\|WP_000714582.1\|126438_127368_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226666
NC_014494.1\|WP_000800417.1\|128408_129884_+\|DUF3502-domain-containing-protein	unknown	unknown	gnl\|CDD\|378792
NC_014494.1\|WP_000808474.1\|132195_133260_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|114011
NC_014494.1\|WP_000836442.1\|142252_142840_+\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|212030
NC_014494.1\|WP_000058099.1\|125898_126120_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_014494.1\|WP_000500038.1\|140458_141331_-\|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-alpha	gnl\|CDD\|129801	TIGR00718, Probable_L-serine_dehydratase_alpha_chain, L-serine dehydratase, iron-sulfur-dependent, alpha subunit. This enzyme is also called serine deaminase. L-serine dehydratase converts serine into pyruvate in the gluconeogenesis pathway from serine. This model describes the alpha chain of an iron-sulfur-dependent L-serine dehydratase, found in Bacillus subtilis. A fairly deep split in a UPGMA tree separates members of this family of alpha chains from the homologous region of single chain forms such as found in Escherichia coli. This family of enzymes is not homologous to the pyridoxal phosphate-dependent threonine deaminases and eukaryotic serine deaminases. [Energy metabolism, Amino acids and amines, Energy metabolism, Glycolysis/gluconeogenesis].	2.65225e-106
NC_014494.1\|WP_000273863.1\|134806_135133_-\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	8.86871e-19
NC_014494.1\|WP_001233690.1\|133322_134234_-\|DUF4097-domain-containing-protein	gnl\|CDD\|372574	pfam13349, DUF4097, Putative adhesin. This has a putative all-beta structure with a twenty-residue repeat with a highly conserved repeating GD, gly-asp, motif. It may form part of a bacterial adhesin.	1.28666e-37
NC_014494.1\|WP_000744897.1\|135271_136438_-\|CynX/NimT-family-MFS-transporter	gnl\|CDD\|225365	COG2807, CynX, Cyanate permease [Inorganic ion transport and metabolism].	4.55787e-126
NC_014494.1\|WP_000200890.1\|139804_140437_-\|HAD-family-hydrolase	gnl\|CDD\|319798	cd04302, HAD_5NT, haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to the Pseudomonas aeruginosa PA0065. 5'-nucleotidases dephosphorylate nucleoside 5'-monophosphates to nucleosides and inorganic phosphate. Purified Pseudomonas aeruginosa PA0065 displayed high activity toward 5'-UMP and 5'-IMP, significant activity against 5'-XMP and 5'-TMP, and low activity against 5'-CMP. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	8.29103e-98
NC_014494.1\|WP_000724267.1\|143981_146090_+\|bacteriocin-associated-integral-membrane-family-protein	gnl\|CDD\|273736	TIGR01654, unnamed_protein_product, bacteriocin-associated integral membrane (putative immunity) protein. This model represents a family of integral membrane proteins, most of which are about 650 residues in size and predicted to span the membrane seven times. Nearly half of the members of this family are found in association with a member of the lactococcin 972 family of bacteriocins (TIGR01653). Others may be associated with uncharacterized proteins that may also act as bacteriocins. Although this protein is suggested to be an immunity protein, and the bacteriocin is suggested to be exported by a Sec-dependent process, the role of this protein is unclear. [Cellular processes, Toxin production and resistance].	0
NC_014494.1\|WP_001035702.1\|137694_139545_+\|polysaccharide-biosynthesis-protein	gnl\|CDD\|224011	COG1086, COG1086, Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism].	0
NC_014494.1\|WP_001075100.1\|127381_128305_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	3.61807e-68
NC_014494.1\|WP_001140363.1\|131263_132115_+\|DUF4299-domain-containing-protein	gnl\|CDD\|339103	pfam14132, DUF4299, Domain of unknown function (DUF4299). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 275 and 313 amino acids in length. There are two conserved sequence motifs: RGF and DAY. There are two completely conserved residues (P and D) that may be functionally important.	1.25306e-121
NC_014494.1\|WP_000198687.1\|134226_134820_-\|DUF1700-domain-containing-protein	gnl\|CDD\|227053	COG4709, COG4709, Predicted membrane protein [Function unknown].	2.84602e-63
NC_014494.1\|WP_001230165.1\|143642_143930_+\|lactococcin-972-family-bacteriocin	gnl\|CDD\|273735	TIGR01653, hypothetical_protein, bacteriocin, lactococcin 972 family. This model represents bacteriocins related to lactococcin 972. Members tend to be found in association with a seven transmembrane putative immunity protein. [Cellular processes, Toxin production and resistance].	6.91587e-26
NC_014494.1\|WP_001030032.1\|130155_131142_+\|rhodanese-related-sulfurtransferase	gnl\|CDD\|234663	PRK00142, PRK00142, rhodanese-related sulfurtransferase.	0
NC_014494.1\|WP_000838912.1\|141339_142011_-\|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-beta	gnl\|CDD\|224674	COG1760, SdaA, L-serine deaminase [Amino acid transport and metabolism].	1.1908e-89
NC_014494.1\|WP_000096192.1\|136495_137656_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|133016	cd02525, Succinoglycan_BP_ExoA, ExoA is involved in the biosynthesis of succinoglycan. Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.	2.51776e-109
NC_014494.1\|WP_000800417.1\|128408_129884_+\|DUF3502-domain-containing-protein	gnl\|CDD\|378792	pfam12010, DUF3502, Domain of unknown function (DUF3502). This presumed domain is functionally uncharacterized. This domain is found in bacteria. This domain is about 140 amino acids in length. This domain is found associated with pfam01547.	4.24398e-44
NC_014494.1\|WP_000808474.1\|132195_133260_-\|hypothetical-protein	gnl\|CDD\|114011	pfam05262, Borrelia_P83, Borrelia P83/100 protein. This family consists of several Borrelia P83/P100 antigen proteins.	0.0011431
NC_014494.1\|WP_000836442.1\|142252_142840_+\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|212030	cd00118, LysM, Lysin Motif is a small domain involved in binding peptidoglycan. LysM, a small globular domain with approximately 40 amino acids, is a widespread protein module involved in binding peptidoglycan in bacteria and chitin in eukaryotes. The domain was originally identified in enzymes that degrade bacterial cell walls, but proteins involved in many other biological functions also contain this domain. It has been reported that the LysM domain functions as a signal for specific plant-bacteria recognition in bacterial pathogenesis. Many of these enzymes are modular and are composed of catalytic units linked to one or several repeats of LysM domains. LysM domains are found in bacteria and eukaryotes.	5.22512e-13
NC_014494.1\|WP_000714582.1\|126438_127368_+\|sugar-ABC-transporter-permease	gnl\|CDD\|226666	COG4209, LplB, ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism].	3.01638e-143

>NC_014494.1|WP_000273863.1|134806_135133_-|PadR-family-transcriptional-regulator
MYFPTSSALIEFLILAVLEQGDSYGYEISQTIKLIANIKESTLYPILKKLEGNSFLTTYSREFQGRMRKYYSLTNGGIEQLLTLKDEWALYTDTINGIIEGSIRHDKN
>NC_014494.1|WP_000198687.1|134226_134820_-|DUF1700-domain-containing-protein
MTRTEYLTQLELYLKKLPEADRIEAMDYFRELFDDAGVEGEEELIASLGTPKEAAHEVLSNLLDKKINEAPAQKNNRQILHIALLALLAAPIGIPLGIAILVTLFAILVAALTVILAFFAVSILGIIGGFLFLVESFTILAQAKSAFILIFGSGLLAIGASSLVLLGISYVARFFGLLIVRLVQFVLKKGKRGNQHA
>NC_014494.1|WP_001233690.1|133322_134234_-|DUF4097-domain-containing-protein
MRKWTKGFLIFGVVTTVIGFILLFVGIQSDGIKSLLSMSKEPVYDSRTEKLTFGKEVENLEITLHQHALTITDSFDDQIHISYHPSLSANHDLITNQNDRTLSLTDKKLSETPFLSSGIGGILHIASSYSSRFEEVILQLPKGRTLKGINISANRGQTTIINASLENATLNTNSYILRIEGSRIKNSKLTTPNIVNIFDTVLTDSQLESTENHFHAENIQVHGKVELTAKDYLRIILDQKESQRINWDISSNYGSIFQFTREKPESRGTELSNPYKTEKTDVKDQLIARSDDNIDLISTPSRR
>NC_014494.1|WP_000808474.1|132195_133260_-|hypothetical-protein
MKQEWFESNDFVKTTSKNKPEERAQEVADKAEETIANLDTPIGKNTQVEEEVSQAEVELESQQEEKIEAPEDSEARTGIEEKKASNSTEEEPDLSKETEKVTIAEESQEALPQQKATTKEPLLISKSLESPYIPDQAPKSRDKWKEQVLDFWSWLVEAIKSPTSKLETSITHSYTAFLLLILFSASSFFFSIYHIKHAYYGHIASINSRFPEQLAPLTLFSIVSILVATTLFFFSFLLGSFVVRRFIHQEKDWTLDKVLQQYSQLLAIPIFLTAIASFFAFFDSLRFTALLCVISIGIILLASLHIITRPSQASETDSFYQLFLSVLVNGVIILLFFVAEVALIGDYLRILAFL
>NC_014494.1|WP_001140363.1|131263_132115_+|DUF4299-domain-containing-protein
MAKTFFIPNKQSILGEQEILNAKSILALLDGLESHSYDVVYLRQPLNRLEYIECAIVGQSQFLFKVSYADGQKAYRVDVPDLLTKTDWQIIKSFLDALLAYTGTDIEGLDGFDFEAYFQASIQAYLADPVARFTICQGIFNPIFFSRENLKSFLEADGLAQFEARVRAVQETDAYFARVSFYQDGEGKVHGVYHLAQGVKTVLPREPFVPAAYIEQLVDKEVQWEIDLVQITGDGSKPEDYESIARLDYAKFLEVLPPSFYHQLDANQIEIQPILVQDFKTLA
>NC_014494.1|WP_001030032.1|130155_131142_+|rhodanese-related-sulfurtransferase
MAKDIRVLLYYLYTPIENAEQFAADHLAFCKSIGLKGRILVADEGINGTVSGDYETTQKYMDYVHSLPGMEELWFKIDEESEQAFKKMFVRYKKEIVHLGLEDNDFDNDINPLETTGAYLSPKEFKEALLDKDTVVLDTRNDYEYDLGHFRGAIRPDIRNFRELPQWVRDNKEKFMDKRVVVYCTGGVRCEKFSGWMVREGYKDVGQLHGGIATYGKDPEVQGELWDGKMYVFDERIAVDVNHVNPTIVGKDWFDGTPCERYVNCGNPFCNRRILTSEENEDKYLRGCSHECRVHPRNRYVSKNELTQAEVIERLAAIGESLDQAATV
>NC_014494.1|WP_000800417.1|128408_129884_+|DUF3502-domain-containing-protein
MKNWKKYAFASASVVALAAGLAACGNLTGNSKKAADSGDKSVIKMYQIGDKPDNLDELLANANKIIEEKVGAKLDIQYLGWGDYGKKMSVITSSGENYDIAFADNYIVNAQKGAYADLTELYKKEGKDLYKALDPAYIKGNTVNGKIYAVPVAANVASSQNFAFNGTLLAKYGIDISGVTSYETLEPVLKQIKEKAPDVVPFAIGKVFIPSDNFDYPVANGLPFVIDLEGDTTKVVNRYEVPRFKEHLKTLHKFYEAGYIPKDVATSDTSFDLQQDTWFVREETVGPADYGNSLLSRVANKDIQIKPITNFIKKNQTTQVANFVISNNSKNKEKSMEILNLLNTNPELLNGLVYGPEGKNWEKIEGKENRVRVLDGYKGNTHMGGWNTGNNWILYINENVTDQQIENSKKELAEAKESPALGFIFNTDNVKSEISAIANTMQQFDTAINTGTVDPDKAIPELMEKLKSEGAYEKVLNEMQKQYDEFLKNKK
>NC_014494.1|WP_001075100.1|127381_128305_+|carbohydrate-ABC-transporter-permease
MAKKKIKKEKIDNVGIHSFSKKADIFFSIISGLIALSCILPFVFVIIISVTDEKSLLQYGYSFFPSQFGLDGFEFLAQFKDKILQALFISVFVTVVGTLTNVFITTTYAYAISRTTFKYRRFFTIFVLLSMLFNAGLVPGYIMVTRVLQLGDTVWALIVPMLLSPFNIILMRSFFKKTIPAAILESARIDGASEARIFFQICLPLSLPGIATITLLTALGFWNDWFNALLYIKSDNLYPLQYLLMQIQQNMDYIAKAVGLTGQLGVALPKETGRMAMVVVATLPIAILYPFFQRYFVKGLTIGGVKE
>NC_014494.1|WP_000714582.1|126438_127368_+|sugar-ABC-transporter-permease
MKKFSKTLRDNWIFLLMVLPGALWLILFFYIPVFGNVVAFKDYHMTSNGFIDSIINSKWVGLDNFRFLFSSRDAFIITRNTVLYNLGFIFLGLVVSVGIAIILSELRSKRMVKIFQTSMLFPYFLSWVIISFFTDAFLNIDKGVFNHLLESLGLKEVNFYADLGIWPYLLLFLGIWKGFGYSSVMYYATIMGIDPTYYEAATVDGASKWQRIRNVTIPQLTPLVTVLTILAVGNIFRADFGLFYQIPHNAGQLYNVTNVLDVYVFNGLTQTADIGMAAAAGLYQSVVGLILVILSNLLARRVDPNSALF
>NC_014494.1|WP_000058099.1|125898_126120_+|hypothetical-protein
MSLQIKLKKLAKELSKLLKDSNLETVDKDVLENSQEELQKAVLFLADEKGSEHTAAELIDNLKEVIAKLKANA
>NC_014494.1|WP_000744897.1|135271_136438_-|CynX/NimT-family-MFS-transporter
MKKQSLFFVPGIILIGVSLRTPFTVLPIILGNISQGLEVEVSSLGVLTSLPLLMFTLFSPFSTQLAQKIGLEHLFTYSLFFLTIGSLIRLINLPLLYLGTLMVGASVAVINVLLPSLIQANQPKKIGFLTTLYVTSMGIATALASYLAVPITQASSWKGLILLLTLLCLATFLVWLPNHRYNHRLAPQTKQKSQIKVMRNKQVWAIIIFSGFQSLIFYTVMTWLPTMSIHAGLSSHEAGLLTSILSLISIPFSMTIPSLTTSLSTRNRQLMLTLVSLAGVVGISMLFFPINNFIYWLAIHLLIGTATSALFPYLMVNFSLKTSAPEKTAQLSGLSQTGGYILAAFGPTLFGYSFDLFHSWVPSVAALLLIDILMTVALFTVDRADKIL
>NC_014494.1|WP_000096192.1|136495_137656_+|glycosyltransferase-family-2-protein
MSSKVSGFQDKNGKVLKIMIEWWKEKFRRVVVTQNVESLLVSIVISAYNEEKYLPGLIEDLKNQTYPKENIEILFINAMSTDGTTAIIQQFIKEDTEFNSIRLYNNPKKNQASGFNLGVKHSVGDLILKIDAHSKVTESFVMNNVAIIQQGEFVCGGPRPTIVEGKGKWAETLHLVEENMFGSSIANYRNSSEDRYVSSIFHGMYKREVFQKVGLVNEQLGRTEDNDIHYRIREHGYKIRYSPSILSYQYIRPTFKKMLHQKYSNGLWIGLTSHVQFKCLSLFHYVPCLFVLSLVFSLALLPITFVFITLLLGAYFLLLSLLTLLTLLKHKNGFLIVMPFLLFSIHFAYGLGTIVGLIRGFKWKKEYKGTIIYLDKISQINQNMLQ
>NC_014494.1|WP_001035702.1|137694_139545_+|polysaccharide-biosynthesis-protein
MNKKLTDYVIDLVEILNKQQKQVFWGIFDIFSMVVSIIVSYILFYGLINPAPVDYIIYTSLAFLFYQLMIGFWGLNASISRYSKITDFMKIFFGVTASSVLSYSICYAFLPLFSIRFIILFILLSTFLILLPRITWQLIYSRRKKGSGDGEHRRTFLIGAGDGGALFMDSYQHPTSELELVGILDKDSKKKGQKLGGIPVLGSYDNLPELAKRHQIERVIVAIPSLDPSEYERILQMCNKLGVKCYKMPKVETVVQGLHQAGTGFQKIDITDLLGRQEIRLDESRLGAELTGKTILVTGAGGSIGSEICRQVSRFNPERIVLLGHGENSIYLVYHELIRKFQGIDYVPVIADIQDYDRLLQVFEQYKPAIVYHAAAHKHVPMMERNPKEAFKNNIRGTYNVARAVDEAKVPKMVMISTDKAVNPPNVMGATKRVAELIVTGFNQRSQSTYCAVRFGNVLGSRGSVIPVFERQIAEGGPVTVTDFRMTRYFMTIPEASRLVIHAGAYAKDGEVFILDMGKPVKIYDLAKKMVLLSGHTESEIPIVEVGIRPGEKLYEELLVSTELVDNQVMDKIFVGKVNVMPLESINQKIGEFRTLSGDELKQAIIAFANQTTHIE
>NC_014494.1|WP_000200890.1|139804_140437_-|HAD-family-hydrolase
MTSITAIFFDLDGTLVDSSIGIHNAFTYTFKELGVPSPDAKTIRGFMGPPLESSFATCLSKDQISEAMQIYRSYYKAKGIYEAQLFPQIIDLLEELSSSYPLYITTTKNTSTAQDMAKNLEIHHFFDGIYGSSPEAPHKADVIHQALQTHQLAPEQAIIIGDTKFDMLGARETGIQKLAVTWGFGEQADLLNYQPDYIAHKPLEVLAYFQ
>NC_014494.1|WP_000500038.1|140458_141331_-|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-alpha
MFYSIKELVEQADLDFQGNVAELMITTEFELTGREREEVFLLMERNLEVMKASVQLGLNENKSRSGLTGGDAAKLDHYIENGKTLSDYTILSAARNAIAVNEHNAKMGLVCATPTAGSAGCLPSVLTAAIEKLDLSHEQQLDFLFAAGAFGLVIANNASISGAEGGCQAEVGSASAMSAAALTLAAGGTPYQASQAIAFVIKNMLGLICDPVAGLVEVPCVKRNAMGASFAFIAADMALAGIESKIPVDEVIDAMYQVGASMPTAFRETAEGGLATTPTGRRLQKEIFGE
>NC_014494.1|WP_000838912.1|141339_142011_-|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-beta
MKSLRFQSVFDIIGPVMIGPSSSHTAGAVRIGKIVSSIFDDTPTEVEFQLFNSFAKTYRGHGTDLALVAGILGMDTDDPEIPNSLEIAHKRGIKIVWTIQKDSNAPHPNTTKITVKNAHKTISVTGISIGGGNIQVTELNGFAVSLNMNTPTIIIVHQDIPGMIALVTEALSRYGINIAQMNVTREKAGEKAIMIIEVDSRNCDEAIEEIRKIPHLHNVNFFK
>NC_014494.1|WP_000836442.1|142252_142840_+|LysM-peptidoglycan-binding-domain-containing-protein
MKSITKKIKATLAGVAALFAVFAPSFVSAQESSTYTVKEGDTLSEIAETHNTTVEKLAENNHIDNIHLIYVDQELVIDGPVAPVATPAPATYAAPAAQDETVSAPVAETPVVSETVVSTVSGSEAEAKEWIAQKESGGSYTATNGRYIGRYQLTDSYLNGDYSAENQERVADAYVAGRYGSWTAAKNFWLNNGWY
>NC_014494.1|WP_001189291.1|142891_143212_-|hypothetical-protein
MQRLEVYKNYQRLYDLRIAILLNLSTLYLYNQDKNMCKQICYTLLEDAKNKKSYDRLAICYVRIGICTDDSKLIQKGFSLLELTEETSMLSHLKKEVEIYYQAKER
>NC_014494.1|WP_001230165.1|143642_143930_+|lactococcin-972-family-bacteriocin
MRKLVKIGVASLMVCGILATTNALAVWVEGGQWNYGVGWTGTFGYSDYLHSTRYHTATVRHGGRTSKDYAKPEAWARASLTKIPPTGMEYFYGFE
>NC_014494.1|WP_000724267.1|143981_146090_+|bacteriocin-associated-integral-membrane-family-protein
MKKISNFCMLLLLLCTTFFVFNVNYTREVVRIQEMGKTVDSLDLYLKDINEPAASVLRFFEDVSKEYKVSIIKTDSGDEVVKSGVFDKDTFPYQEFGISSLDFTTDGEGVYSNKEISNKLGTIPTFLKAKPIQLMTFQTYIKDTSRSLNGRYTITSTQEMDKDRIVQKWSDFFKIDQATLLEPTYKSAVEVINRDLLLSAIVFVLAILLLVLVTVYQPMMEMKRVGVQKLLGFQDRAVLADVVKGNLYLLLGGTLVINLGVFFLLDYKPKDLFPMLWLSHFLLLQLYLFISWLTYLLIQKMTISSLLKGFSSFKFGLIFNYVMKIGTTILLTALLIGVGRSLEQENKELAYQQQWVSQGNYLTLETFKLNDNLWQEELAGSGKSTDYFYRFYQDLVEKTQAGYVQSSSLPVKNFVQSEQIQQYQLTDTVDVYYANRNFLKSKGFKLPNTGIKKVILMPASTKGEEDKNQLLGKLIAFHSMKYEEQQKRTIEEMDVEIAYYEGDWSFFPYSDKRKENLSNPIISLVNDSDMMWDEKASLSTTGLNNPIKIENTVQHQKEITELVEKLSDGNYLKFSSIQAIQQEKVDSYRDAVRNFNLLFALFGLLSMMISYFLLVTTFLLKRRDIITKKFMGWKLVDRYRPLLVLLLLGYSFPLLVLIFFAHAFLPLLLFAGFTCLDILFVLGLASSMEKRSLVELLKGGIL

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Crispr_ID: NC_014494_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014494_2

1685035-1685119

Orphan

Consensus_repeat	Method
TTTTTGAAACGTTTCATTTTTTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014494_2

>merge|NC_014494|2|1685035-1685119|CRISPRCasFinder
TTTTTGAAACGTTTCATTTTTTTCTAGAAAAGATAGCGCTTGGCGCTGTCTCTTTATTTCTTTTTTTGAAACGTTTCATTTTTGT

>NC_014494|2|2|1685035-1685119|CRISPRCasFinder
TTTTTGAAACGTTTCATTTTTTT	CTAGAAAAGATAGCGCTTGGCGCTGTCTCTTTATTTCTT
TTTTTGAAACGTTTCATTTTTGT

Protein	Signature genes	Signature genes Name	Protein_function
NC_014494.1\|WP_000669742.1\|1681560_1683177_-\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270299
NC_014494.1\|WP_000109957.1\|1690133_1690337_+\|CsbD-family-protein	unknown	unknown	gnl\|CDD\|225777
NC_014494.1\|WP_000782428.1\|1692255_1693104_-\|formylglycine-generating-enzyme-family-protein	unknown	unknown	gnl\|CDD\|335469
NC_014494.1\|WP_000961810.1\|1676753_1677206_-\|type-II-toxin-antitoxin-system-HicB-family-antitoxin	unknown	unknown	gnl\|CDD\|224514
NC_014494.1\|WP_001809002.1\|1688459_1688624_+\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	unknown	unknown	gnl\|CDD\|225170
NC_014494.1\|WP_000502556.1\|1680231_1681551_-\|glycoside-hydrolase-family-32-protein	unknown	unknown	gnl\|CDD\|224536
NC_014494.1\|WP_001132284.1\|1677242_1677422_-\|type-II-toxin-antitoxin-system-HicA-family-toxin	unknown	unknown	gnl\|CDD\|377942
NC_014494.1\|WP_000030213.1\|1688707_1689274_+\|alkaline-shock-response-membrane-anchor-protein-AmaP	unknown	unknown	gnl\|CDD\|380217
NC_014494.1\|WP_000230202.1\|1685173_1686175_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_014494.1\|WP_000064115.1\|1689494_1690103_+\|Asp23/Gls24-family-envelope-stress-response-protein	unknown	unknown	gnl\|CDD\|224221
NC_014494.1\|WP_001084977.1\|1684106_1685024_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226666
NC_014494.1\|WP_075329187.1\|1677902_1678118_-\|hypothetical-protein	unknown	unknown	unknown
NC_014494.1\|WP_000455066.1\|1689285_1689456_+\|DUF2273-domain-containing-protein	unknown	unknown	gnl\|CDD\|227834
NC_014494.1\|WP_001113212.1\|1678415_1679687_+\|replication-associated-recombination-protein-A	unknown	unknown	gnl\|CDD\|237355
NC_014494.1\|WP_001844038.1\|1690917_1691193_+\|IS30-family-transposase	unknown	unknown	gnl\|CDD\|225382
NC_014494.1\|WP_001205280.1\|1686535_1688017_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|285470
NC_014494.1\|WP_001048906.1\|1677558_1677738_-\|hypothetical-protein	unknown	unknown	unknown
NC_014494.1\|WP_000797961.1\|1683205_1684096_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_014494.1\|WP_000229334.1\|1691470_1692241_-\|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl\|CDD\|376667
NC_014494.1\|WP_000257086.1\|1675992_1676463_-\|DUF3013-family-protein	unknown	unknown	gnl\|CDD\|337951

Protein	Function_ID	Function_description	E-value
NC_014494.1\|WP_000669742.1\|1681560_1683177_-\|extracellular-solute-binding-protein	gnl\|CDD\|270299	cd13581, PBP2_AlgQ_like_2, Periplasmic-binding component of alginate-specific ABC uptake system-like; contains the type 2 periplasmic binding fold. This subgroup includes uncharacterized periplasmic-binding proteins that are closely related to high molecular weight (HMW) alginate bining proteins (AlgQ1 and AlgQ2) found in gram-negative soil bacteria. The HMW alginate uptake system is composed of a novel pit formed on the cell surface and a pit-dependent ATP-binding cassette (ABC) transporter in the inner membrane. The transportation of HMW alginate from the pit to the ABC transporter is mediated by periplasmic HMW alginate-binding proteins (AlgQ1 and AlgQ2). Alginate is an anionic polysaccharide that is made up of alpha-L-mannuronate and its 5'-epimer, alpha-L-guluronate. Alginate is present in the cell walls of brown seaweeds, where it forms a viscous gum by binding water. Alginate is also produced by two bacteria genera Pseudomonas and Azotobacter. AlgQ1 and AlgQ2 belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. However, unlike other bacterial periplasmic-binding proteins that deliver small solutes to ABC transporters, AlgQ1/2 can bind a macromolecule and may have specificity for either sugar or a certain type of polysaccharide.	0
NC_014494.1\|WP_000109957.1\|1690133_1690337_+\|CsbD-family-protein	gnl\|CDD\|225777	COG3237, COG3237, Uncharacterized protein conserved in bacteria [Function unknown].	1.20386e-07
NC_014494.1\|WP_000782428.1\|1692255_1693104_-\|formylglycine-generating-enzyme-family-protein	gnl\|CDD\|335469	pfam03781, FGE-sulfatase, Sulfatase-modifying factor enzyme 1. This domain is found in eukaryotic proteins required for post-translational sulfatase modification (SUMF1). These proteins are associated with the rare disorder multiple sulfatase deficiency (MSD). The protein product of the SUMF1 gene is FGE, formylglycine (FGly),-generating enzyme, which is a sulfatase. Sulfatases are enzymes essential for degradation and remodelling of sulfate esters, and formylglycine (FGly), the key catalytic in the active site, is unique to sulfatases. FGE is localized to the endoplasmic reticulum (ER) and interacts with and modifies the unfolded form of newly synthesized sulfatases. FGE is a single-domain monomer with a surprising paucity of secondary structure that adopts a unique fold which is stabilized by two Ca2+ ions. The effect of all mutations found in MSD patients is explained by the FGE structure, providing a molecular basis for MSD. A redox-active disulfide bond is present in the active site of FGE. An oxidized cysteine residue, possibly cysteine sulfenic acid, has been detected that may allow formulation of a structure-based mechanism for FGly formation from cysteine residues in all sulfatases. In Mycobacteria and Treponema denticola this enzyme functions as an iron(II)-dependent oxidoreductase.	1.46637e-65
NC_014494.1\|WP_000961810.1\|1676753_1677206_-\|type-II-toxin-antitoxin-system-HicB-family-antitoxin	gnl\|CDD\|224514	COG1598, COG1598, Predicted nuclease of the RNAse H fold, HicB family [General function prediction only].	1.2282e-11
NC_014494.1\|WP_000502556.1\|1680231_1681551_-\|glycoside-hydrolase-family-32-protein	gnl\|CDD\|224536	COG1621, SacC, Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism].	5.58833e-179
NC_014494.1\|WP_001132284.1\|1677242_1677422_-\|type-II-toxin-antitoxin-system-HicA-family-toxin	gnl\|CDD\|377942	pfam07927, HicA_toxin, HicA toxin of bacterial toxin-antitoxin,. HicA_toxin is a bacterial family of toxins that act as mRNA interferases. The antitoxin that neutralizes this is family HicB, pfam15919.	7.34944e-09
NC_014494.1\|WP_000230202.1\|1685173_1686175_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	6.78682e-99
NC_014494.1\|WP_000064115.1\|1689494_1690103_+\|Asp23/Gls24-family-envelope-stress-response-protein	gnl\|CDD\|224221	COG1302, COG1302, Uncharacterized protein conserved in bacteria [Function unknown].	1.35166e-33
NC_014494.1\|WP_001084977.1\|1684106_1685024_-\|sugar-ABC-transporter-permease	gnl\|CDD\|226666	COG4209, LplB, ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism].	1.26851e-137
NC_014494.1\|WP_000030213.1\|1688707_1689274_+\|alkaline-shock-response-membrane-anchor-protein-AmaP	gnl\|CDD\|380217	NF033218, anchor_AmaP, alkaline shock response membrane anchor protein AmaP. The founding member of this family, AmaP (Asp23 membrane anchoring protein), is related to Asp23 through part of its length, but includes a highly hydrophobic N-terminal region that should make it an integral membrane protein. Asp23 (alkaline shock protein of 23 kDa), described in PMID:7864904, is a cytosolic protein in Staphylococcus aureus, strongly induced by a pH shift from 7 to 10, and also recruited to the membrane. AmaP appears to be the partner protein with an integral membrane segment and the ability to anchor Asp23 to the membrane. This model was built to identify full-length homologs of AmaP, while excluding Asp23. Some but not all members of this family score above the cutoffs of Pfam model version PF03780.11, but full-length homologs of Asp23 score considerably higher. Asp23 family members previously were known as DUF322.	7.65552e-46
NC_014494.1\|WP_000455066.1\|1689285_1689456_+\|DUF2273-domain-containing-protein	gnl\|CDD\|227834	COG5547, COG5547, Small integral membrane protein [Function unknown].	9.45975e-16
NC_014494.1\|WP_001113212.1\|1678415_1679687_+\|replication-associated-recombination-protein-A	gnl\|CDD\|237355	PRK13342, PRK13342, recombination factor protein RarA; Reviewed.	0
NC_014494.1\|WP_001844038.1\|1690917_1691193_+\|IS30-family-transposase	gnl\|CDD\|225382	COG2826, Tra8, Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair].	1.65112e-12
NC_014494.1\|WP_001205280.1\|1686535_1688017_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|285470	pfam08270, PRD_Mga, M protein trans-acting positive regulator (MGA) PRD domain. Mga is a DNA-binding protein that activates the expression of several important virulence genes in group A streptococcus in response to changing environmental conditions. This corresponds to the PRD like region.	1.09342e-73
NC_014494.1\|WP_000257086.1\|1675992_1676463_-\|DUF3013-family-protein	gnl\|CDD\|337951	pfam11217, DUF3013, Protein of unknown function (DUF3013). This bacterial family of proteins with unknown function appear to be restricted to Firmicutes.	2.18144e-65
NC_014494.1\|WP_000797961.1\|1683205_1684096_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	4.20755e-67
NC_014494.1\|WP_000229334.1\|1691470_1692241_-\|sulfite-exporter-TauE/SafE-family-protein	gnl\|CDD\|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	2.31002e-16
NC_014494.1\|WP_001809002.1\|1688459_1688624_+\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	gnl\|CDD\|225170	COG2261, COG2261, Predicted membrane protein [Function unknown].	6.92661e-06

>NC_014494.1|WP_001084977.1|1684106_1685024_-|sugar-ABC-transporter-permease
MNSKAKQVSLWERIKKQKLLLLMTVPGLVLTFIFKYIPMYGVLIAFKDYNPLKGILGSDWIGFSEFTKFISSPNFGILLANTLKLSIYGLLLGFLPPIILAIMLNQLLSEKVKKRIQLILYAPNFISVVVIVGMIFLFFSVGGPINNFLSMFGMKADFLTNPDFFRPLYIFSGIWQGMGWASTLYTATLVNVDPALVEAARLDGANIFQRIWHIDIPALKPIMVIQFVLAAGGIMNVGYEKAFLMQTSLNLPTSEIISTYDYKVGLVSGDYSYSTAVGLFNAVINVVLLVAVNQIVKRMNNGEGI
>NC_014494.1|WP_000797961.1|1683205_1684096_-|carbohydrate-ABC-transporter-permease
MKNSIMDTKFDRRILLLNKIIIVFIVLMTLLPLLYIVVASFMDPKVLVSRGISFNPADWTVEGYQRVFSDQSILRGFINSLLYSFGFAALTVLLSVFTAYPLSKKDLVGRRWINYFLIVTMFFGGGLVPTYLLVKELGMLNTPWAIIVPGAVNVWNIILARAYFQGLPEELVEAAVIDGANDLQIFFKIMLPLAKPIMFVLFLYAFVGQWNSYFDAMIYIKDPNLEPLQLVLRKILIQSQPGQDMIGAQAAMNEMKRLAELIKYATIVISSLPLIVMYPFFQKYFDKGIMAGSLKG
>NC_014494.1|WP_000669742.1|1681560_1683177_-|extracellular-solute-binding-protein
MKFKTFSKSAVLLTASLAVLAACGSKNTASSPDYKLEGVTFPLQEKKTLKFMTASSPLSPKDPNEKLILQRLEKETGVHIDWTNYQSDFAEKRNLDISSGDLPDAIHNDGASDVDLMNWAKKGVIIPVEDLIDKYMPNLKKILDEKPEYKALMTAPDGHIYSFPWIEELGDGKESIHSVNDMAWINKDWLKKLGLEMPKATDDLIKVLEAFKNGDPNGNGEADEIPFSFISGNGNEDFKFLFAAFGIGDNDDHLVVGNDGKVDFTADNDNYKEGVKFIRQLQEKGLIDKEAFEHDWNSYIAKGHDQKFGVYFTWDKNNVTGSNESYDVLPVLAGPSGQKHVARTNGMGFARDKMVITSVNKNLELTAKWIDAQYAPLQSVQNNWGTYGDDKQQNIFELDQASNSLKHLPLNGTAPAELRQKTEVGGPLAILDSYYGKVTTIPDDAKWRLDLIKEYYVPYMSNDNNYPRVFMTQEDLDKIAHIEADMNDYIYRKRAEWIVNGNIDTEWDDYKKELEKYGLSNYLAIKQKYYDQYQANKN
>NC_014494.1|WP_000502556.1|1680231_1681551_-|glycoside-hydrolase-family-32-protein
MGDKKYTVEKANRFIAENKHLVNTQYKPEEHFSAEIGWINDPNGFVYFRGEYHLFYQFYPYDSVWGPMHWGHAKSKDLVTWEHLPVALAPDQDYDRNGCFSGSAIVKDDRLWLMYTGHIEEKTGVRQVQNMAFSDDGIHFEKISQNPVATGSDLPDELIAADFRDPKLFEKDGRYYSVVAAKHKDNVGCIVLLGSDNLVEWQFESIFLKGGEHQGFMWECPDYFELDGKDCLIMSPMRYQREGDSYHNINSSLLFTGKVDWREKRFIPESVQEIDHGQDFYAPQTLLDDQNRRILIAWMQTWGRTLPTHDQEHKWACAMTLPRILRLEDGKLRQFPVKKGQYQIQIDKDCHYHLGNDTDYLEFGYDSNAQQVYIDRSHLIQKILGEEEQDTSRRYVDIEAKELEVVLDKNSIEIFVNQGEASLTATYYLTVPAELSRID
>NC_014494.1|WP_001113212.1|1678415_1679687_+|replication-associated-recombination-protein-A
MPDNLALRMRPKTIDQVIGQEHLVGPGKIIRRMVEANRLSSMILYGPPGIGKTSIASAIAGTTKYAFRTFNATVDSKKRLQEISEEAKFSGGLVLLLDEIHRLDKTKQDFLLPLLESGLVIMIGATTENPFFSVTPAIRSRVQIFELEPLSNQDVKEALQIALSNPERGFDFPIELDEDALDFIATSTNGDLRSAFNSLDLAVLSTPENDEGIRHITLDIMENSLQRSYITMDKDGDGHYDVLSALQKSIRGSDVDASLHYTARLIEAGDLPSLARRLTVIAYEDIGLANPEAQIHTVTALDAAQKIGFPEARILIANVVIDLALSPKSNSAYVAMDKALADLKTSGHLPIPRHLRDGHYSGSKELGNAQDYLYPHNYPGNWIKQDYLPEKIRNHHYFQAEDTGKYERALAQRKEAIDRLRKI
>NC_014494.1|WP_075329187.1|1677902_1678118_-|hypothetical-protein
MMELPSQEILIFTKQIRHWILSDQVISGKRKLFFREDTPKEILDLYENIKSKLDFAYQEVHSNNGLKKYEK
>NC_014494.1|WP_001048906.1|1677558_1677738_-|hypothetical-protein
MNLIFEEYQFVKIGDKKYRVRSVPMIHSTPPQSVLDRDTFTIDYTDDELLDKEAVFTTH
>NC_014494.1|WP_001132284.1|1677242_1677422_-|type-II-toxin-antitoxin-system-HicA-family-toxin
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGELNKYTERGIRKQAGL
>NC_014494.1|WP_000961810.1|1676753_1677206_-|type-II-toxin-antitoxin-system-HicB-family-antitoxin
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPFKDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA
>NC_014494.1|WP_000257086.1|1675992_1676463_-|DUF3013-family-protein
MATYGFLDILEEELDKNFPFDFEISWDKRNHAVEVSFLLEAQNAAGVEMVDEDGEVSSDDILFEEAVLFYNPAKSTVNEEDYLTVIPYLPKKGFSREFLAYFALFLKDTAEVGLDVLMDFLEDPEAEEFVMEWNQEVFEEGKIGLEKGEFYPYPKY
>NC_014494.1|WP_000230202.1|1685173_1686175_-|LacI-family-DNA-binding-transcriptional-regulator
MVEQRKSITMKDVALEAGVSVGTVSRVINKEKGIKEVTLKKVEQAIKTLNYIPDYYARGMKKNRTETIAIIVPSIWHPFFSEFAMHVENEVYKRNNKLLLCSINGTNREQDYLEMLRHNKVDGVVAITYSPIEHYLTSGIPFVSIDRTYSDIAIPCVSSDNDAGGREAAKQLISKGCQHLAFVGGHNTTINETKRRRISFEKYVQEHKIPLSIFDLDETVTDYYGKLESFLEENSSIDGIFTINDFTALDVIEILEKNGKRIPHDVQIIGYDGIKMAGDRDYLLSTIEQPLEEMAKEAVRILFDIIDGKTVNLQTILPVKFVEGKTTKNENKS
>NC_014494.1|WP_001205280.1|1686535_1688017_-|helix-turn-helix-domain-containing-protein
MRDLLSKKSHRQLELLELLFEHKRWFHRSELAELLNCTERAVKDDLSHVKSAFPDLIFHSSTNGIRIINTDDSDIEMVYHHFFKHSTHFSILEFIFFNEGCQAESICKEFYISSSSLYRIISQINKVIKRQFQFEVSLTPVQIIGNERDIRYFFAQYFSEKYYFLEWPFENFSSEPLSQLLELVYKETSFPMNLSTHRMLKLLLVTNLYRIKFGHFMEVDKDSFNDQSLDFLMQAEGIEGVAQSFESEYNISLDEEVVCQLFVSYFQKMFFIDESLFMKCVKKDSYVEKSYHLLSDFIDQISVKYQIEMENKDNLIWHLHNTAHLYRQELFTEFILFDQKGNTIRNFQNIFPKFVSDIKKELSHYLETLEVCSSSMMVNHLSYTFITHTKHLVINLLQNQPKLKVLVMSNFDQYHAKFVAETLSYYCSNNFELEVWTELELSKESLEDSPYDIIISNFIIPPIENKRLIYSNNINTVSLIYLLNAMMFIRLDE
>NC_014494.1|WP_001809002.1|1688459_1688624_+|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein
MGIIANVFAGLVGAYAGQSLLGSWGPSIAGMALLPSIVGAAIVITVVSFFTGRK
>NC_014494.1|WP_000030213.1|1688707_1689274_+|alkaline-shock-response-membrane-anchor-protein-AmaP
MSKAKKICFIIFCILILTIFLPVLIDYHQVSDLGIHLLSWRQNSVVEFYLARYVFWGTVVLSTLVLLSILVVMFYPKRYLEIQLETKNDTLKLKNSAIEGFVRSLVSDHRLIKNPTVHVNLRKNKCFVHVEGKILPSDNIADRCQIIQNEITNGLKQFFGIERQVKLEVAVKNYQPKPQNKKTVSRVK
>NC_014494.1|WP_000455066.1|1689285_1689456_+|DUF2273-domain-containing-protein
MEWLKQYRYPIIAGLIGVFLACLIVSFGFFKTIFVLILGALGVAAGLYIEKNYIDK
>NC_014494.1|WP_000064115.1|1689494_1690103_+|Asp23/Gls24-family-envelope-stress-response-protein
MSNEKNTNTNVEKKDATVVAHEIKGELTYEDKVIQKIIGLSLENVSGLLGIDGGFFSNLKEKIVNSDDVTSGVNVEVGKTQVAVDLNVIVEYQKNVPALYSEIREIVSSEVAKMTDLEIVEINVNVVDIKTKEQHEADSVSLQDRVSDVAESTGEFTSEQFEKAKSGLGSGFSTVQEKVSEGVEAVKGAANGVVSHENTRVN
>NC_014494.1|WP_000109957.1|1690133_1690337_+|CsbD-family-protein
MSVEEKLNQAKGSIKEGVGKAIGDEKMEKEGAAEKVVSKVKEVAEDAKDAVEGAVEGVKNMLSGDDK
>NC_014494.1|WP_001844038.1|1690917_1691193_+|IS30-family-transposase
MKTKSRKAKDMAESIQGWLAQFLVNLFKSITFDCGKEFSKWKDISNHHDSESFFANLGCSRQRRLNEHSNRLLRCHDLPKQTDFNEVSQEF
>NC_014494.1|WP_000229334.1|1691470_1692241_-|sulfite-exporter-TauE/SafE-family-protein
MVEIIYFLIIIIASGLGSISGMGGGIIIKPLMDSFGYHSVSDIAFYSSFSVFIMAIISTIKRFSQSKEIKWRLIFTVSFSSVLGGFLGHLIFQVLLYQLSVRLVSIVQMILLFVMLLVSFVLTDFKKTYQFDKIGFYMICGLLLGLISSFLGIGGGPLNVSLLMVFFSISIKEATMYSLAIIFFSQLSHLATIVVVTGLNQYHLAPVPVIFLASICGGVLGTVVSKVLPENWVRYCFKGMLFFVMGMTLYNLFHIL
>NC_014494.1|WP_000782428.1|1692255_1693104_-|formylglycine-generating-enzyme-family-protein
MKMKKIKGGTFMMGTNSEEGFLDDFEGPQVAVSVKDFSIADTPVTNQEFAQFVKETGYKTLAERQEWSFVFILFVPEAEREGYPHPAGAPWWLQVSNACWKHPYGENNNLVGLEDHPVVHVALEDALAFCNWSGMSLPTEAQWEYAARGGRQSEYPWGDTLLEGGYYHANTWQGRFPYENTALDGFIGTAPVYEFLPNDFGLYQMIGNVWEWCRNPRYTLLASFNEDDYELPKYGIQDEEYAIRGGSFLCHCSYCNRYRVAARNGCISTSTSSHLGFRCLKE

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

4381 : 60512

Streptococcus_phage(87.5%)

protease,tail,holin,head,terminase,tRNA,portal,capsid,integrase

attL 23321:23341|attR 59310:59330

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000163932.1\|4381_4951_+\|tRNA	aminoacyl-tRNA hydrolase	NA	NA	NA	NA
WP_000258110.1\|4951_8461_+	transcription-repair coupling factor	NA	NA	NA	NA
WP_001234978.1\|8518_8785_+	RNA-binding S4 domain-containing protein	NA	NA	NA	NA
WP_000041909.1\|8777_9146_+	septum formation initiator family protein	NA	NA	NA	NA
WP_001224747.1\|9265_10534_+	serine hydrolase	NA	NA	NA	NA
WP_001208981.1\|10530_11808_+\|tRNA	tRNA lysidine(34) synthetase TilS	A7K9Y8	Acanthocystis_turfacea_chlorella_virus	2.5e-06	24.1
WP_000892184.1\|11811_12354_+	hypoxanthine phosphoribosyltransferase	A0A218MMB5	uncultured_virus	2.7e-10	28.9
WP_000744551.1\|12369_14328_+\|protease	ATP-dependent zinc metalloprotease FtsH	H8ZJI5	Ostreococcus_tauri_virus	2.4e-109	45.8
WP_013315017.1\|14449_14713_+	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_000939546.1\|21472_21709_+	hypothetical protein	NA	NA	NA	NA
WP_000205044.1\|21939_23226_+	adenylosuccinate synthase	L7Y4J5	Megavirus	2.7e-72	37.1
23321:23341	attL	NA	NA	NA	NA
WP_000876727.1\|23467_24616_-\|integrase	site-specific integrase	A0A1S5SCM1	Streptococcus_phage	1.2e-217	100.0
WP_000539947.1\|24786_25587_-	HIRAN domain-containing protein	A0A1S5SDT5	Streptococcus_phage	1.1e-113	99.6
WP_000069476.1\|25713_26469_-	helix-turn-helix transcriptional regulator	A0A1S5SD15	Streptococcus_phage	1.2e-141	100.0
WP_001171134.1\|26642_26849_+	helix-turn-helix transcriptional regulator	A0A1S5SCX8	Streptococcus_phage	1.1e-31	100.0
WP_000289447.1\|27156_27834_-	DUF4145 domain-containing protein	A0A1S5SCM5	Streptococcus_phage	7.6e-127	100.0
WP_001002349.1\|27888_28602_+	ORF6C domain-containing protein	A0A1S5SCR9	Streptococcus_phage	1.4e-134	100.0
WP_000370959.1\|28614_28872_+	hypothetical protein	A0A1S5SEV6	Streptococcus_phage	1.2e-43	100.0
WP_000462823.1\|28957_29278_+	hypothetical protein	A0A1S5SCK7	Streptococcus_phage	1.9e-48	100.0
WP_000391814.1\|29293_29587_+	hypothetical protein	A0A1S5SCP4	Streptococcus_phage	3.1e-37	100.0
WP_001289767.1\|29579_30407_+	phage replisome organizer N-terminal domain-containing protein	A0A1S5SCN0	Streptococcus_phage	3.5e-150	100.0
WP_000511765.1\|30394_30553_+	hypothetical protein	A0A1S5SCK8	Streptococcus_phage	2.1e-24	100.0
WP_000228218.1\|30546_31317_+	ATP-binding protein	A0A1S5SD21	Streptococcus_phage	5.2e-140	100.0
WP_000470303.1\|31331_31526_+	hypothetical protein	A0A1S5SCY7	Streptococcus_phage	1.8e-28	100.0
WP_000891969.1\|31525_31753_+	hypothetical protein	A0A1S5SCL8	Streptococcus_phage	2.3e-40	100.0
WP_001105098.1\|31937_32147_+	hypothetical protein	A0A1S5SCS9	Streptococcus_phage	1.5e-28	100.0
WP_000969666.1\|32118_32436_+	hypothetical protein	A0A1S5SCY1	Streptococcus_phage	7.8e-58	100.0
WP_001859446.1\|32869_33133_+	hypothetical protein	A0A1S5SCL9	Streptococcus_phage	1.3e-42	100.0
WP_001177094.1\|33370_33724_+	helix-turn-helix transcriptional regulator	A0A1S5SCQ5	Streptococcus_phage	1.4e-63	100.0
WP_000516820.1\|33705_34170_+	hypothetical protein	A0A1S5SCN9	Streptococcus_phage	4.9e-85	100.0
WP_001028147.1\|34278_34821_+\|integrase	site-specific integrase	A0A1S5SCL7	Streptococcus_phage	9.8e-101	100.0
WP_000143215.1\|35250_35568_+	HNH endonuclease	A0A1S5SD32	Streptococcus_phage	1.5e-56	100.0
WP_000601030.1\|35704_36190_+	hypothetical protein	A0A1S5SCZ6	Streptococcus_phage	5.0e-80	99.4
WP_000230006.1\|36182_37895_+\|terminase	terminase	A0A1S5SCM6	Streptococcus_phage	0.0e+00	100.0
WP_001812652.1\|37903_39046_+\|portal	phage portal protein	A0A1S5SCP3	Streptococcus_phage	1.2e-217	100.0
WP_000413203.1\|39092_39635_+\|head,protease	HK97 family phage prohead protease	A0A1S5SCT6	Streptococcus_phage	1.2e-98	100.0
WP_000855224.1\|39649_40903_+\|capsid	phage major capsid protein	A0A1S5SCZ2	Streptococcus_phage	4.4e-229	100.0
WP_000154006.1\|40928_41264_+	hypothetical protein	A0A1S5SCM7	Streptococcus_phage	4.1e-57	100.0
WP_000842790.1\|41260_41566_+\|head,tail	head-tail adaptor protein	A0A1S5SCR5	Streptococcus_phage	9.5e-37	100.0
WP_001074487.1\|41565_41913_+	hypothetical protein	A0A1S5SCP8	Streptococcus_phage	3.5e-59	100.0
WP_000534621.1\|41899_42244_+	hypothetical protein	A0A1S5SCM8	Streptococcus_phage	1.2e-59	100.0
WP_000221469.1\|42257_42926_+	hypothetical protein	A0A1S5SD39	Streptococcus_phage	7.0e-125	100.0
WP_000591561.1\|42927_43404_+	hypothetical protein	A0A1S5SD04	Streptococcus_phage	7.8e-86	100.0
WP_000852166.1\|43590_46329_+\|tail	phage tail tape measure protein	A0A1S5SCN8	Streptococcus_phage	0.0e+00	100.0
WP_000161552.1\|46325_47048_+\|tail	phage tail protein	A0A1S5SCQ3	Streptococcus_phage	3.6e-135	100.0
WP_013315019.1\|47048_56156_+\|tail	tail fiber domain-containing protein	A0A1S5SCU8	Streptococcus_phage	0.0e+00	100.0
WP_001063633.1\|56152_56269_+	hypothetical protein	A0A1S5SCF0	Streptococcus_phage	4.0e-12	100.0
WP_001091114.1\|56249_56453_+	hypothetical protein	A0A1S5SCN6	Streptococcus_phage	2.9e-26	100.0
WP_000852253.1\|56455_56806_+	hypothetical protein	A0A1S5SCS3	Streptococcus_phage	6.2e-64	100.0
WP_001165344.1\|56815_57232_+\|holin	phage holin family protein	A0A1S5SCE8	Streptococcus_phage	1.9e-67	100.0
WP_001186238.1\|57235_57568_+\|holin	phage holin	A0A1S5SCN7	Streptococcus_phage	1.6e-50	100.0
WP_000350465.1\|57571_58528_+	N-acetylmuramoyl-L-alanine amidase LytA	A0A1S5SD48	Streptococcus_phage	4.3e-144	100.0
WP_001209433.1\|58665_58845_-	hypothetical protein	Q3BLW4	Phage_SK137	3.5e-23	96.6
WP_001030863.1\|58986_59136_-	hypothetical protein	C5J952	Streptococcus_phage	9.1e-17	95.9
WP_000291875.1\|59415_59883_+	nucleoside deaminase	NA	NA	NA	NA
59310:59330	attR	NA	NA	NA	NA
WP_000701993.1\|60068_60512_+	dUTP diphosphatase	Q2WG49	Clostridium_botulinum_D_phage	3.1e-28	46.7

DBSCAN-SWA_2

75777 : 87088

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000668281.1\|75777_77931_+	peptide cleavage/export ABC transporter	W8CYL7	Bacillus_phage	1.4e-44	28.0
WP_000801606.1\|77943_79293_+	HlyD family secretion protein	NA	NA	NA	NA
WP_000043305.1\|79462_80170_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A1D8KNF0	Synechococcus_phage	1.0e-41	39.2
WP_000361232.1\|80226_83952_+	phosphoribosylformylglycinamidine synthase	A6N228	Microbacterium_phage	2.8e-37	25.8
WP_000220625.1\|84044_85487_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	2.2e-54	34.9
WP_000182582.1\|85523_86546_+	phosphoribosylformylglycinamidine cyclo-ligase	A0A1D7SE90	Cyanophage	1.6e-64	43.9
WP_000717501.1\|86542_87088_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	9.7e-24	35.0

DBSCAN-SWA_3

108381 : 170684

Streptococcus_phi-m46.1-like_phage(16.67%)

tRNA,protease,bacteriocin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001810309.1\|108381_113952_+\|protease	zinc metalloprotease ZmpC	NA	NA	NA	NA
WP_000220734.1\|114307_115162_+	VOC family protein	NA	NA	NA	NA
WP_000200247.1\|115267_115825_+	sugar O-acetyltransferase	NA	NA	NA	NA
WP_000615007.1\|116041_116806_+	nucleoside phosphorylase	F5CA76	Streptococcus_phi-m46.1-like_phage	1.3e-58	69.0
WP_000897726.1\|117418_118798_+	TrkH family potassium uptake protein	NA	NA	NA	NA
WP_001283896.1\|118811_119477_+	TrkA family potassium uptake protein	NA	NA	NA	NA
WP_000692802.1\|119611_119815_+	hypothetical protein	NA	NA	NA	NA
WP_000771910.1\|119876_120050_+	hypothetical protein	NA	NA	NA	NA
WP_000291610.1\|120116_120527_+	hypothetical protein	NA	NA	NA	NA
WP_000671448.1\|120642_122304_+	YSIRK signal domain/LPXTG anchor domain surface protein	NA	NA	NA	NA
WP_000520642.1\|122470_123169_+	response regulator transcription factor	W8CYM9	Bacillus_phage	2.0e-37	39.0
WP_000769768.1\|123165_124218_+	HAMP domain-containing histidine kinase	NA	NA	NA	NA
WP_000092756.1\|124412_125024_+	30S ribosomal protein S4	NA	NA	NA	NA
WP_001810173.1\|125684_125945_+	hypothetical protein	NA	NA	NA	NA
WP_000058099.1\|125898_126120_+	hypothetical protein	NA	NA	NA	NA
WP_000714582.1\|126438_127368_+	sugar ABC transporter permease	NA	NA	NA	NA
WP_001075100.1\|127381_128305_+	carbohydrate ABC transporter permease	NA	NA	NA	NA
WP_000800417.1\|128408_129884_+	DUF3502 domain-containing protein	NA	NA	NA	NA
WP_001030032.1\|130155_131142_+	rhodanese-related sulfurtransferase	NA	NA	NA	NA
WP_001140363.1\|131263_132115_+	DUF4299 domain-containing protein	NA	NA	NA	NA
WP_000808474.1\|132195_133260_-	hypothetical protein	NA	NA	NA	NA
WP_001233690.1\|133322_134234_-	DUF4097 domain-containing protein	NA	NA	NA	NA
WP_000198687.1\|134226_134820_-	DUF1700 domain-containing protein	NA	NA	NA	NA
WP_000273863.1\|134806_135133_-	PadR family transcriptional regulator	NA	NA	NA	NA
WP_000744897.1\|135271_136438_-	CynX/NimT family MFS transporter	NA	NA	NA	NA
WP_000096192.1\|136495_137656_+	glycosyltransferase family 2 protein	NA	NA	NA	NA
WP_001035702.1\|137694_139545_+	polysaccharide biosynthesis protein	A0A2P1ELS8	Moumouvirus	2.2e-27	30.1
WP_000200890.1\|139804_140437_-	HAD family hydrolase	NA	NA	NA	NA
WP_000500038.1\|140458_141331_-	L-serine ammonia-lyase, iron-sulfur-dependent, subunit alpha	NA	NA	NA	NA
WP_000838912.1\|141339_142011_-	L-serine ammonia-lyase, iron-sulfur-dependent, subunit beta	NA	NA	NA	NA
WP_000836442.1\|142252_142840_+	LysM peptidoglycan-binding domain-containing protein	A0A288TY55	Enterococcus_phage	1.7e-26	56.2
WP_001189291.1\|142891_143212_-	hypothetical protein	NA	NA	NA	NA
WP_001230165.1\|143642_143930_+\|bacteriocin	lactococcin 972 family bacteriocin	NA	NA	NA	NA
WP_000724267.1\|143981_146090_+\|bacteriocin	bacteriocin-associated integral membrane family protein	NA	NA	NA	NA
WP_000571330.1\|146086_146728_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	4.3e-23	34.8
WP_001038474.1\|146934_147741_+	transporter substrate-binding domain-containing protein	NA	NA	NA	NA
WP_001810313.1\|147757_148954_+	argininosuccinate synthase	NA	NA	NA	NA
WP_001107608.1\|148982_150374_+	argininosuccinate lyase	NA	NA	NA	NA
WP_001268159.1\|150560_151424_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_000915346.1\|151889_152228_+	peptidase C39	NA	NA	NA	NA
WP_000424410.1\|152205_152700_+	hypothetical protein	NA	NA	NA	NA
WP_000909535.1\|152853_153066_+	hypothetical protein	NA	NA	NA	NA
WP_000513492.1\|153545_153791_+	hypothetical protein	NA	NA	NA	NA
WP_001810315.1\|153947_155006_+	hypothetical protein	NA	NA	NA	NA
WP_001810319.1\|155320_156298_+	hypothetical protein	NA	NA	NA	NA
WP_000424474.1\|156674_157049_+\|bacteriocin	SPH_0224 family bacteriocin-like peptide	NA	NA	NA	NA
WP_000619748.1\|157256_158159_+	hypothetical protein	NA	NA	NA	NA
WP_000366642.1\|158214_158454_+	hypothetical protein	NA	NA	NA	NA
WP_000072912.1\|158450_159179_+	hypothetical protein	NA	NA	NA	NA
WP_000770312.1\|160311_160551_+	hypothetical protein	NA	NA	NA	NA
WP_001810010.1\|160535_160814_+	hypothetical protein	M1Q0Z8	Streptococcus_phage	1.1e-20	50.5
WP_001035331.1\|161099_163379_+	pneumococcal surface protein A	NA	NA	NA	NA
WP_001282982.1\|163779_164901_+\|tRNA	tRNA 2-thiouridine(34) synthase MnmA	NA	NA	NA	NA
WP_000193637.1\|165041_165497_+	NUDIX hydrolase	NA	NA	NA	NA
WP_000220964.1\|165506_167420_+\|tRNA	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG	NA	NA	NA	NA
WP_000331980.1\|167614_169294_-	ribonuclease J	NA	NA	NA	NA
WP_000639577.1\|169295_169529_-	DNA-dependent RNA polymerase auxiliary subunit epsilon family protein	NA	NA	NA	NA
WP_000184676.1\|169910_170132_+	hypothetical protein	NA	NA	NA	NA
WP_000974047.1\|170344_170497_-\|bacteriocin	fratricide two-peptide bacteriocin subunit CibB	NA	NA	NA	NA
WP_000180803.1\|170498_170684_-\|bacteriocin	fratricide two-peptide bacteriocin subunit CibA	NA	NA	NA	NA

DBSCAN-SWA_4

445208 : 508569

Planktothrix_phage(11.11%)

transposase,bacteriocin,protease,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001809505.1\|445208_445379_-\|transposase	transposase	NA	NA	NA	NA
WP_000628994.1\|446028_447252_-	ROK family transcriptional regulator	NA	NA	NA	NA
WP_001059630.1\|447419_448742_+	PTS sugar transporter subunit IIC	NA	NA	NA	NA
WP_000836780.1\|450799_451144_+	PTS lactose/cellobiose transporter subunit IIA	NA	NA	NA	NA
WP_000429427.1\|451153_452566_+	6-phospho-beta-galactosidase	NA	NA	NA	NA
WP_000359732.1\|452635_454312_+	PTS transporter subunit EIIC	NA	NA	NA	NA
WP_001809506.1\|454437_455877_-	TrkH family potassium uptake protein	NA	NA	NA	NA
WP_000691685.1\|455880_457230_-	Trk system potassium transporter TrkA	NA	NA	NA	NA
WP_001063601.1\|457418_458267_+	S-adenosyl-l-methionine hydroxide adenosyltransferase family protein	NA	NA	NA	NA
WP_000403169.1\|458281_458830_+	ECF-type riboflavin transporter substrate-binding protein	NA	NA	NA	NA
WP_000693545.1\|458836_459049_+	hypothetical protein	NA	NA	NA	NA
WP_000656536.1\|459150_460833_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	4.5e-19	34.4
WP_001148103.1\|460817_461648_+	energy-coupling factor transporter transmembrane protein EcfT	NA	NA	NA	NA
WP_000181374.1\|461840_462344_+\|tRNA	tRNA (cytidine(34)-2'-O)-methyltransferase	NA	NA	NA	NA
WP_000185835.1\|462796_463360_+	ECF transporter S component	NA	NA	NA	NA
WP_001813491.1\|463373_464000_+	phosphatase PAP2 family protein	NA	NA	NA	NA
WP_000867286.1\|464027_464417_+	hypothetical protein	NA	NA	NA	NA
WP_000333649.1\|464421_464871_+	N-acetyltransferase	NA	NA	NA	NA
WP_000764656.1\|464998_465586_+	DNA-directed RNA polymerase subunit delta	NA	NA	NA	NA
WP_000105242.1\|465975_467583_+	CTP synthase	A0A1J0FA14	Only_Syngen_Nebraska_virus	8.9e-142	47.0
WP_000026628.1\|468141_469773_-	Na/Pi cotransporter family protein	NA	NA	NA	NA
WP_000795162.1\|470065_475006_+	bacterial Ig-like domain-containing protein	NA	NA	NA	NA
WP_001096743.1\|475095_476292_+	phosphoglycerate kinase	NA	NA	NA	NA
WP_000119905.1\|476427_476955_+	aromatic acid exporter family protein	NA	NA	NA	NA
WP_000659547.1\|477031_477388_+	transcriptional repressor GlnR	NA	NA	NA	NA
WP_001122900.1\|477424_478771_+	type I glutamate--ammonia ligase	NA	NA	NA	NA
WP_001808898.1\|478866_478986_-	hypothetical protein	NA	NA	NA	NA
WP_001813510.1\|480788_481394_-	restriction endonuclease subunit S	NA	NA	NA	NA
WP_000651177.1\|481404_482202_-	tyrosine-type DNA invertase PsrA	A0A0H4TI16	Erysipelothrix_phage	1.3e-21	28.7
WP_000029036.1\|483825_485289_-	SAM-dependent DNA methyltransferase	NA	NA	NA	NA
WP_000229098.1\|485301_487635_-	DEAD/DEAH box helicase family protein	A0A097BY72	Enterococcus_phage	1.2e-25	26.5
WP_001088677.1\|488241_488751_+	DUF2812 domain-containing protein	NA	NA	NA	NA
WP_000255787.1\|488914_489949_+	heat-inducible transcriptional repressor HrcA	NA	NA	NA	NA
WP_000046031.1\|489975_490500_+	nucleotide exchange factor GrpE	NA	NA	NA	NA
WP_000034662.1\|490979_492803_+	molecular chaperone DnaK	A0A0N9QXN8	Chrysochromulina_ericina_virus	1.3e-133	47.2
WP_000343113.1\|492813_493218_+	hypothetical protein	NA	NA	NA	NA
WP_001066301.1\|493561_494698_+	molecular chaperone DnaJ	E3T4P7	Cafeteria_roenbergensis_virus	1.7e-22	31.0
WP_001810526.1\|494726_494903_-	hypothetical protein	NA	NA	NA	NA
WP_000777760.1\|495064_495352_-	hypothetical protein	NA	NA	NA	NA
WP_001278301.1\|495361_495772_-	HIT family protein	B5LJ12	Mycobacterium_phage	3.4e-05	31.6
WP_000889923.1\|495839_496571_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	9.0e-25	28.6
WP_000653768.1\|496567_497617_+	ABC transporter permease	NA	NA	NA	NA
WP_000132583.1\|497784_498114_-	hypothetical protein	NA	NA	NA	NA
WP_000682136.1\|498390_498729_+	response regulator transcription factor	NA	NA	NA	NA
WP_001219137.1\|498733_499471_+	response regulator transcription factor	NA	NA	NA	NA
WP_001099894.1\|499484_500825_+	sensor histidine kinase	NA	NA	NA	NA
WP_000358812.1\|500868_501024_-	quorum-sensing system pheromone BlpC	NA	NA	NA	NA
WP_001069065.1\|501080_502442_-\|bacteriocin	bacteriocin secretion accessory protein	NA	NA	NA	NA
WP_000205159.1\|502452_504606_-	peptide cleavage/export ABC transporter BlpA	W8CYL7	Bacillus_phage	2.4e-41	27.7
WP_001093255.1\|504887_505142_+\|bacteriocin	two-peptide bacteriocin subunit BlpM	NA	NA	NA	NA
WP_001099490.1\|505157_505361_+\|bacteriocin	two-peptide bacteriocin subunit BlpN	NA	NA	NA	NA
WP_001809846.1\|505604_505754_+\|bacteriocin	bacteriocin-like peptide BlpO	NA	NA	NA	NA
WP_000346296.1\|505857_505977_+	hypothetical protein	NA	NA	NA	NA
WP_001810529.1\|506444_506816_+	hypothetical protein	NA	NA	NA	NA
WP_000877381.1\|507444_507828_+	hypothetical protein	NA	NA	NA	NA
WP_000760515.1\|507879_508569_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA

DBSCAN-SWA_5

916926 : 926577

Streptococcus_phage(88.89%)

holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000728250.1\|916926_918822_+\|holin	phosphorylcholine esterase CbpE	Q332B9	Clostridium_botulinum_C_phage	5.6e-10	23.7
WP_075218898.1\|918901_920032_+	glutamate 5-kinase	A0A1X9I5D0	Streptococcus_phage	1.1e-114	58.4
WP_000254679.1\|920041_921304_+	glutamate-5-semialdehyde dehydrogenase	A0A1X9I5D4	Streptococcus_phage	1.3e-140	65.0
WP_000689709.1\|921307_922105_+	pyrroline-5-carboxylate reductase	A0A1X9I6T5	Streptococcus_phage	2.7e-59	50.6
WP_000033362.1\|922324_922963_+	dTMP kinase	M1PSC7	Streptococcus_phage	9.8e-76	68.1
WP_000806706.1\|922959_923850_+	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	1.4e-72	51.4
WP_000358228.1\|923889_924207_+	DNA replication initiation control protein YabA	M1PFV3	Streptococcus_phage	2.9e-28	60.0
WP_001166869.1\|924209_925079_+	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	2.3e-115	75.7
WP_001261449.1\|925305_925824_+	ClbS/DfsB family four-helix bundle protein	NA	NA	NA	NA
WP_000345256.1\|925932_926070_+	replication initiator protein A	NA	NA	NA	NA
WP_013315084.1\|926076_926577_+	replication initiator protein A	A0A2P0VK56	Streptococcus_phage	5.2e-08	40.0

DBSCAN-SWA_6

1388433 : 1446116

Streptococcus_phage(23.53%)

transposase,holin,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000691853.1\|1388433_1388628_-\|transposase	transposase	NA	NA	NA	NA
WP_001813431.1\|1388824_1389148_-	IS66 family insertion sequence element accessory protein TnpB	NA	NA	NA	NA
WP_001136122.1\|1389128_1389314_-	hypothetical protein	NA	NA	NA	NA
WP_000065723.1\|1389617_1391180_-	glutamine-hydrolyzing GMP synthase	A0A1V0SH76	Hokovirus	1.4e-19	32.8
WP_000936187.1\|1391321_1392020_+	GntR family transcriptional regulator	NA	NA	NA	NA
WP_000071672.1\|1392062_1392959_-	EamA family transporter	NA	NA	NA	NA
WP_000872206.1\|1392967_1393903_-	serine hydrolase	NA	NA	NA	NA
WP_001102211.1\|1393899_1394625_-	CppA family protein	NA	NA	NA	NA
WP_000290657.1\|1394708_1395344_-\|holin	1-alkyl-2-acetylglycerophosphocholine esterase	A0A2K9L661	Tupanvirus	8.7e-08	28.7
WP_000972931.1\|1395345_1396173_-	Cof-type HAD-IIB family hydrolase	NA	NA	NA	NA
WP_001272961.1\|1397771_1398383_+	peptide deformylase	E3SLL2	Synechococcus_phage	4.9e-16	42.4
WP_000855753.1\|1398427_1399156_+	23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB	NA	NA	NA	NA
WP_000272294.1\|1399195_1400107_-	thioredoxin-disulfide reductase	G3MA85	Bacillus_virus	5.9e-90	51.5
WP_000926599.1\|1400172_1400397_-	DUF4059 family protein	NA	NA	NA	NA
WP_000590970.1\|1400474_1401218_-	amino acid ABC transporter ATP-binding protein	W5SAS9	Pithovirus	1.6e-13	27.4
WP_001103449.1\|1401217_1402018_-	amino acid ABC transporter permease	NA	NA	NA	NA
WP_000889093.1\|1402175_1402532_-	arsenate reductase family protein	M1PLC0	Streptococcus_phage	1.2e-33	57.3
WP_001170346.1\|1402544_1403057_-	methylated-DNA--[protein]-cysteine S-methyltransferase	M1PFU9	Streptococcus_phage	1.3e-46	55.6
WP_000405832.1\|1403056_1403551_-	GNAT family N-acetyltransferase	M1PSC3	Streptococcus_phage	1.9e-42	52.1
WP_000858730.1\|1403685_1404132_+	DUF1836 domain-containing protein	NA	NA	NA	NA
WP_001097986.1\|1404128_1404776_+	hemolysin III family protein	NA	NA	NA	NA
WP_000689945.1\|1404796_1405378_-	pyridoxal 5'-phosphate synthase glutaminase subunit PdxT	NA	NA	NA	NA
WP_000138529.1\|1405378_1406254_-	pyridoxal 5'-phosphate synthase lyase subunit PdxS	NA	NA	NA	NA
WP_000036793.1\|1406405_1407785_-	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_000175407.1\|1408078_1409002_+	FAD:protein FMN transferase	NA	NA	NA	NA
WP_000915959.1\|1409061_1409667_+	NAD(P)H-dependent oxidoreductase	A0A2P0ZL77	Lactobacillus_phage	7.7e-54	54.2
WP_000673690.1\|1409685_1410930_+	NAD(P)H-dependent oxidoreductase	A0A2P0ZL82	Lactobacillus_phage	1.7e-55	52.7
WP_000371287.1\|1411152_1411410_-	DUF896 family protein	NA	NA	NA	NA
WP_000164762.1\|1411451_1413488_-\|tRNA	glycine--tRNA ligase subunit beta	NA	NA	NA	NA
WP_000038742.1\|1413699_1414617_-\|tRNA	glycine--tRNA ligase subunit alpha	NA	NA	NA	NA
WP_000429566.1\|1414811_1415573_-	hypothetical protein	NA	NA	NA	NA
WP_001099678.1\|1415845_1416688_-	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	1.3e-51	40.2
WP_001854799.1\|1416801_1418193_-	polysaccharide deacetylase family protein	NA	NA	NA	NA
WP_001810453.1\|1418427_1418805_-\|transposase	PD-(D/E)XK nuclease family transposase	NA	NA	NA	NA
WP_000915887.1\|1419019_1419997_+	Gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
WP_000850585.1\|1419993_1421076_+	DEAD/DEAH box helicase	Q5GF26	Diachasmimorpha_longicaudata_entomopoxvirus	1.8e-37	31.3
WP_001040724.1\|1422571_1423768_-	elongation factor Tu	A0A076FFS6	Aureococcus_anophage	7.3e-32	29.6
WP_001155321.1\|1423931_1424885_-\|transposase	IS30-like element ISSpn8 family transposase	H7BWC8	unidentified_phage	1.6e-34	35.2
WP_000348126.1\|1425922_1426792_-	aquaporin family protein	NA	NA	NA	NA
WP_000248992.1\|1427015_1427537_-	LPXTG cell wall anchor domain-containing protein	NA	NA	NA	NA
WP_001021423.1\|1427494_1428601_-	MucBP domain-containing protein	NA	NA	NA	NA
WP_000935666.1\|1428711_1428966_-	hypothetical protein	NA	NA	NA	NA
WP_088778989.1\|1429305_1429752_-\|transposase	transposase	NA	NA	NA	NA
WP_000121708.1\|1430382_1432101_+	phospho-sugar mutase	A0A1X9I671	Streptococcus_phage	8.9e-273	83.2
WP_000434651.1\|1432211_1432559_+	thioredoxin	NA	NA	NA	NA
WP_000759193.1\|1432837_1433674_-	amino acid ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_000891769.1\|1433686_1434316_-	amino acid ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	1.5e-28	37.3
WP_000120830.1\|1434325_1434967_-	amino acid ABC transporter permease	NA	NA	NA	NA
WP_001065946.1\|1435112_1436342_-	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_000435455.1\|1436331_1437498_-	AI-2E family transporter	NA	NA	NA	NA
WP_000665619.1\|1437641_1438655_+	lactonase family protein	NA	NA	NA	NA
WP_000068050.1\|1438699_1439119_-	F0F1 ATP synthase subunit epsilon	NA	NA	NA	NA
WP_000094360.1\|1439129_1440536_-	F0F1 ATP synthase subunit beta	NA	NA	NA	NA
WP_000301210.1\|1440621_1441500_-	F0F1 ATP synthase subunit gamma	NA	NA	NA	NA
WP_000996644.1\|1441515_1443021_-	F0F1 ATP synthase subunit alpha	NA	NA	NA	NA
WP_000359036.1\|1443035_1443572_-	F0F1 ATP synthase subunit delta	NA	NA	NA	NA
WP_000558554.1\|1443571_1444066_-	F0F1 ATP synthase subunit B	NA	NA	NA	NA
WP_000392848.1\|1444079_1444796_-	F0F1 ATP synthase subunit A	NA	NA	NA	NA
WP_001054562.1\|1444830_1445031_-	F0F1 ATP synthase subunit C	NA	NA	NA	NA
WP_013315128.1\|1445105_1446116_-\|transposase	IS30 family transposase	H7BUM7	unidentified_phage	1.2e-32	34.3

DBSCAN-SWA_7

1493724 : 1500475

Streptococcus_phage(50.0%)

protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000081010.1\|1493724_1494690_+	NAD(P)/FAD-dependent oxidoreductase	Q9JRK7	Streptococcus_phage	4.8e-66	99.2
WP_000011306.1\|1494723_1495635_-	DNA-binding protein WhiA	Q7AWZ3	Streptococcus_phage	1.5e-154	99.7
WP_001231085.1\|1495631_1496609_-	YvcK family protein	A1IMD5	Streptococcus_phage	3.4e-184	99.7
WP_000163033.1\|1496605_1497496_-	RNase adapter RapZ	A0A0R8VB27	Thermobifida_phage	3.9e-06	29.8
WP_001140412.1\|1497547_1497928_-	RidA family protein	NA	NA	NA	NA
WP_000422599.1\|1497938_1498526_-	YihA family ribosome biogenesis GTP-binding protein	NA	NA	NA	NA
WP_000106346.1\|1498534_1499767_-\|protease	ATP-dependent Clp protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	4.2e-131	59.0
WP_000442275.1\|1499798_1499969_-	hypothetical protein	NA	NA	NA	NA
WP_000162484.1\|1499968_1500475_-	dihydrofolate reductase	G3MBI7	Bacillus_virus	6.7e-27	42.5

DBSCAN-SWA_8

1754342 : 1761674

uncultured_Mediterranean_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000167818.1\|1754342_1755044_+	UDP-glucose 4-epimerase	A0A2K9L1R4	Tupanvirus	1.2e-34	36.1
WP_000777248.1\|1755466_1756426_+	ABC transporter permease	A0A2H4IY97	uncultured_Caudovirales_phage	4.0e-57	40.8
WP_001193661.1\|1756415_1757372_+	iron chelate uptake ABC transporter family permease subunit	NA	NA	NA	NA
WP_000764303.1\|1757368_1758121_+	ATP-binding cassette domain-containing protein	W6JKT0	Anomala_cuprea_entomopoxvirus	5.6e-14	28.1
WP_000858252.1\|1758216_1759182_+	siderophore ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_000821640.1\|1759406_1759649_-	membrane protein insertion efficiency factor YidD	A0A2H4PQM5	Staphylococcus_phage	1.3e-17	59.4
WP_001222228.1\|1759648_1760371_-	rRNA pseudouridine synthase	NA	NA	NA	NA
WP_000105310.1\|1760357_1760927_-	segregation/condensation protein B	A0A1B1IVT7	uncultured_Mediterranean_phage	5.0e-15	34.9
WP_000351907.1\|1760945_1761674_-	segregation/condensation protein A	A0A1B1IVW1	uncultured_Mediterranean_phage	5.3e-09	22.3

DBSCAN-SWA_9

2107207 : 2115961

Streptococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000510412.1\|2107207_2108047_-	energy-coupling factor transporter ATPase	A0A2H4PQG7	Staphylococcus_phage	1.1e-13	27.6
WP_000835721.1\|2108031_2108859_-	energy-coupling factor transporter ATPase	G3M9Y6	Bacillus_virus	3.1e-21	31.8
WP_000712132.1\|2108855_2109401_-	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase	NA	NA	NA	NA
WP_001227958.1\|2109411_2110233_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_000170183.1\|2110274_2111558_-	insulinase family protein	A0A1E1EST3	Acanthamoeba_castellanii_mimivirus	1.4e-17	30.0
WP_000424272.1\|2111554_2112805_-	insulinase family protein	A0A1X9I714	Streptococcus_phage	2.7e-93	42.3
WP_000455903.1\|2112963_2113332_+	S4 domain-containing protein YaaA	A0A1X9I5V8	Streptococcus_phage	7.0e-18	57.3
WP_000266666.1\|2113334_2114432_+	DNA replication/repair protein RecF	NA	NA	NA	NA
WP_000073428.1\|2114482_2115961_-	IMP dehydrogenase	A0A1V0SHK8	Klosneuvirus	2.2e-94	40.5

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_014494

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection