CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_015957	Streptomyces violaceusniger Tu 4113, complete sequence	27 crisprs	WYL,c2c9_V-U4,DinG,DEDDh,csa3,Cas14u_CAS-V,casR,RT,cas14j,cas4,PD-DExK	2	11	10	2
NC_015951	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence	4 crisprs	c2c9_V-U4,WYL,cas2,cas6e,cas5,cas7,cse2gr11,cas8e,cas3,DEDDh	1	33	1	0
NC_015952	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI02, complete sequence	1 crisprs	DEDDh	1	2	0	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_015957_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015957_1

133542-133646

Orphan

Consensus_repeat	Method
CCGCGCCGTCCGCCGTACGCCGCCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015957_1

>merge|NC_015957|1|133542-133646|CRISPRCasFinder
CCGCGCCGCCCCGCGCCAGCCGCGCCGTCCGCCGTACGCCGCCCCGCCCCGCGCCGCGCCGCCCCGCGCCGCGCCGCGCCAGCGCCAGCCGCCCCGCGCCGTCCG

>NC_015957|1|1|133542-133646|CRISPRCasFinder
CCGCGCCGCCCCGCGCCAGCCGCGCC	GTCCGCCGTACGCCGCCCCGCCCCGCGCCGCGCCGCCCCGCGCCGCGCCGCGC
CAGCGCCAGCCGCCCCGCGCCGTCCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_015957.1\|WP_106685818.1\|138675_139734_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366161
NC_015957.1\|WP_043237568.1\|143051_144254_+\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223737
NC_015957.1\|WP_014053674.1\|130739_131387_+\|TetR/AcrR-family-transcriptional-regulator-C-terminal-ligand-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|379883
NC_015957.1\|WP_014053673.1\|128055_128985_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NC_015957.1\|WP_014053685.1\|140942_141863_+\|dihydrodipicolinate-synthase-family-protein	unknown	unknown	gnl\|CDD\|188630
NC_015957.1\|WP_014053681.1\|137467_137893_+\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014053686.1\|141965_142967_+\|proline-racemase-family-protein	unknown	unknown	gnl\|CDD\|368491
NC_015957.1\|WP_014043695.1\|129156_129465_+\|transposase	unknown	unknown	gnl\|CDD\|366690
NC_015957.1\|WP_014053678.1\|133660_134761_-\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|224458
NC_015957.1\|WP_014053676.1\|132133_132802_-\|DUF3105-domain-containing-protein	unknown	unknown	gnl\|CDD\|378632
NC_015957.1\|WP_014053670.1\|126130_126457_+\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_167543177.1\|132898_133375_-\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_078505056.1\|144250_145054_+\|(2Fe-2S)-binding-protein	unknown	unknown	gnl\|CDD\|379229
NC_015957.1\|WP_043235174.1\|127413_127965_-\|transferase	unknown	unknown	gnl\|CDD\|100047
NC_015957.1\|WP_014053680.1\|136564_137284_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_015957.1\|WP_043237564.1\|134902_136267_-\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|223944
NC_015957.1\|WP_014053682.1\|137889_138150_+\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014043694.1\|129461_130382_+\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|222853
NC_015957.1\|WP_014053671.1\|126467_127361_-\|IS5-family-transposase	unknown	unknown	gnl\|CDD\|379129
NC_015957.1\|WP_106685817.1\|131423_132095_-\|DUF305-domain-containing-protein	unknown	unknown	gnl\|CDD\|367619

Protein	Function_ID	Function_description	E-value
NC_015957.1\|WP_106685818.1\|138675_139734_-\|hypothetical-protein	gnl\|CDD\|366161	pfam00553, CBM_2, Cellulose binding domain. Two tryptophan residues are involved in cellulose binding. Cellulose binding domain found in bacteria.	5.21004e-25
NC_015957.1\|WP_043237568.1\|143051_144254_+\|FAD-binding-oxidoreductase	gnl\|CDD\|223737	COG0665, DadA, Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism].	1.0896e-56
NC_015957.1\|WP_014053674.1\|130739_131387_+\|TetR/AcrR-family-transcriptional-regulator-C-terminal-ligand-binding-domain-containing-protein	gnl\|CDD\|379883	pfam16859, TetR_C_11, Bacterial transcriptional repressor C-terminal. This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. Another target protein is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli.	2.45765e-19
NC_015957.1\|WP_014053673.1\|128055_128985_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	5.45623e-30
NC_015957.1\|WP_014053685.1\|140942_141863_+\|dihydrodipicolinate-synthase-family-protein	gnl\|CDD\|188630	cd00408, DHDPS-like, Dihydrodipicolinate synthase family. Dihydrodipicolinate synthase family. A member of the class I aldolases, which use an active-site lysine which stabilizes a reaction intermediate via Schiff base formation, and have TIM beta/alpha barrel fold. The dihydrodipicolinate synthase family comprises several pyruvate-dependent class I aldolases that use the same catalytic step to catalyze different reactions in different pathways and includes such proteins as N-acetylneuraminate lyase, MosA protein, 5-keto-4-deoxy-glucarate dehydratase, trans-o-hydroxybenzylidenepyruvate hydratase-aldolase, trans-2'-carboxybenzalpyruvate hydratase-aldolase, and 2-keto-3-deoxy- gluconate aldolase. The family is also referred to as the N-acetylneuraminate lyase (NAL) family.	6.12819e-86
NC_015957.1\|WP_014053686.1\|141965_142967_+\|proline-racemase-family-protein	gnl\|CDD\|368491	pfam05544, Pro_racemase, Proline racemase. This family consists of proline racemase (EC 5.1.1.4) proteins which catalyze the interconversion of L- and D-proline in bacteria. This family also contains several similar eukaryotic proteins including Trypanosoma cruzi PA45-A, a protein with B-cell mitogenic properties which has been characterized as a co-factor-independent proline racemase.	2.06556e-157
NC_015957.1\|WP_014043695.1\|129156_129465_+\|transposase	gnl\|CDD\|366690	pfam01527, HTH_Tnp_1, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.	3.3962e-10
NC_015957.1\|WP_014053678.1\|133660_134761_-\|AMP-binding-protein	gnl\|CDD\|224458	COG1541, PaaK, Coenzyme F390 synthetase [Coenzyme metabolism].	4.63451e-09
NC_015957.1\|WP_014053676.1\|132133_132802_-\|DUF3105-domain-containing-protein	gnl\|CDD\|378632	pfam11303, DUF3105, Protein of unknown function (DUF3105). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.	1.14907e-59
NC_015957.1\|WP_078505056.1\|144250_145054_+\|(2Fe-2S)-binding-protein	gnl\|CDD\|379229	pfam13510, Fer2_4, 2Fe-2S iron-sulfur cluster binding domain. The 2Fe-2S ferredoxin family have a general core structure consisting of beta(2)-alpha-beta(2) which a beta-grasp type fold. The domain is around one hundred amino acids with four conserved cysteine residues to which the 2Fe-2S cluster is ligated. This cluster appears within sarcosine oxidase proteins.	4.46904e-25
NC_015957.1\|WP_043235174.1\|127413_127965_-\|transferase	gnl\|CDD\|100047	cd03357, LbH_MAT_GAT, Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6 position of the nonreducing end glucosyl moiety. GAT specifically acetylates galactopyranosides. Furthermore, MAT shows higher affinity toward artificial substrates containing an alkyl or hydrophobic chain as well as a glucosyl unit. Active MAT and GAT are homotrimers, with each subunit consisting of an N-terminal alpha-helical region and a C-terminal left-handed parallel alpha-helix (LbH) subdomain with 6 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X).	2.97943e-69
NC_015957.1\|WP_014053680.1\|136564_137284_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	7.02788e-77
NC_015957.1\|WP_043237564.1\|134902_136267_-\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|223944	COG1012, PutA, NAD-dependent aldehyde dehydrogenases [Energy production and conversion].	4.9362e-12
NC_015957.1\|WP_014043694.1\|129461_130382_+\|IS3-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	1.78354e-73
NC_015957.1\|WP_014053671.1\|126467_127361_-\|IS5-family-transposase	gnl\|CDD\|379129	pfam13340, DUF4096, Putative transposase of IS4/5 family (DUF4096).	2.0966e-30
NC_015957.1\|WP_106685817.1\|131423_132095_-\|DUF305-domain-containing-protein	gnl\|CDD\|367619	pfam03713, DUF305, Domain of unknown function (DUF305). Domain found in small family of bacterial secreted proteins with no known function. Also found in Paramecium bursaria chlorella virus 1. This domain is short and found in one or two copies. The domain has a conserved HH motif that may be functionally important. This domain belongs to the ferritin superfamily. It contains two sequence similar repeats each of which is composed of two alpha helices.	7.98464e-43

>NC_015957.1|WP_167543177.1|132898_133375_-|hypothetical-protein
MGRGRGGEGHIRRDAVRGTVPSVLCRAVLLLAAAIWVAPSCVHPAADHNGLSAGCPRRLTDTVASAEPHEKPVTYPSPGHGPSDGSGSGSGSGSGSGSDDCVTGPRGVVQALVPTPVPPLFLAEVPPPGGHRNPDSVRAPPDHPVRALGLHQLQVLRT
>NC_015957.1|WP_014053676.1|132133_132802_-|DUF3105-domain-containing-protein
MGSKGSKTKGTAADRRAKIEELRRAEKARERRFRAITVTSVAVIVAGLAVGGYFLVDASDKKDKKEAKVTSTVVQTGEFKGMKTWKNLGRTHVQGTVKYAMSPPVGGNHNQVWQNCNGDVYTKPLAKENAVHALEHGAVWVTYTDKAPKEDIAALSERVKKTPYSMISPYQEQDAPIVLNAWGNQLDIQKASDPRVAAFFKKFVQGKQTPEPGAYCTNGKTS
>NC_015957.1|WP_106685817.1|131423_132095_-|DUF305-domain-containing-protein
MVAGITAAFALVTLVAVAVLWLTSDRSEGTTDTGTPKDTSAEAGFARDMSVHHQQAVEMSFIVRDRTSDDEVRRLAFDIASTQATQSGMLQGWLDMWGLDKTSEDPPMTWMKHGMDGMEGMDHGSMKGMDGGGAYKPHDGSLMPGMATNTQLDELRKAKGKAAEVLYLKLMTAHHKGGVAMAKGAVELVKDPTEKHLATTMVQGQQSEIELMAGMLKARGASS
>NC_015957.1|WP_014053674.1|130739_131387_+|TetR/AcrR-family-transcriptional-regulator-C-terminal-ligand-binding-domain-containing-protein
MTERPPHGSARPGGRTARTRAAVLAAAYEELDRDSFAALTLDRLARRSGVHVSTIRRRWRTVEGVVVDLLAEHSSTLPTPDTGDFRRDLTQLTQAIADFNNALRNRNVIQGLLAAAAHDSRVEEIVRAAFVRRTEEVTLIARQAVERGEIPEGTEAREVIAALAAPLYYRMLILRGPIDERLVHTSVEATYQAARSGVFVPKGDGKGDRKGDPEG
>NC_015957.1|WP_014043694.1|129461_130382_+|IS3-family-transposase
MTALVDAHPHLGVEPVLRELSIPSSTYYRWRQAEKEPCKRRRQDAELTGKIRQVHADSGGIYGSPRVHAVLRREGIHVGRKRIERLMRQAGLAGISPRRGKGFTRRDPDAEPAPDLVQRDFTANVPNRLWVTDLTMIATEEGPLWLSAIRDAFSRRVVAWETSARADADLVLTTLEYALASREVAPGELIHHADHGCQYTSVKLTTRLVRAGIQASMGSVGDSFDNALAENLWMVIKTECIRGRVFPTRAEANLTLFEYIDGFYNPRRIQKRLGYLSPIEYEEKHYASQATAEQVNLKPRQPSLTS
>NC_015957.1|WP_014043695.1|129156_129465_+|transposase
MPAPRKYPLELRDRAVRMYRAAEPKPVIRRMAEELGVHHEALRNWIRQAEADAGERGDILTTAEREELAALRKENAQLKRANEVLRTASAFFAAQLDPTRPR
>NC_015957.1|WP_014053673.1|128055_128985_+|LysR-family-transcriptional-regulator
MDVEALRTFVAVAETGQFQAAADKLGISQQAVSKRIAALERHIEVTLLVRTSRGSRLSLDGQVFLPHAKKVLAALEQAEQAVRPGSRPLRVDVLNRRISPAQAVYRFYRSHPETDLDAVTLSKENAAQAAQAVLEGTVDASFRALPADQVPAGISAERLLDAPLELLVGPGHPLADASWVSPADLAGHRIWIPGIRPGMEWAAFYQALSEAFGLSIDALGPNFGDEALMDALADSASLATLVGSGDRYLWPQTHDLRRIPLHDPTPVYPHVLLFRSGDQHPVLTALRDHLRTAGPRTPHDVWAPDWVDR
>NC_015957.1|WP_043235174.1|127413_127965_-|transferase
MSTRTEQVMYIQTPEFARHAERIVEVTDATSRLNVLPFSDSEGRTELLSVVFGGPLPESVMIYPPFFTESGLNTTFGENVFVNQGCTFMDKGGIRIGNGVMIAPKVSLITGGHPLPLAERREYLSFAPIVIEDDVWIGTAAVITQGVTIGAGAVVAAGAVVTRDVPAGTVVAGVPARLIKTID
>NC_015957.1|WP_014053671.1|126467_127361_-|IS5-family-transposase
MPRHARLTDRQWDRIRPLLPSSTGRRGRPWADHRRIVEAIVYRYRTGIPWRDLPARFGSWKTVWARHRRWAADGTWDRVLGVLLARADDDGLIDWRVAVDSTITRAHQHATNTRRPEKCRAAARGQGLDAHREPAGHAIGRSRGGLTTKIHHAVDGQGRPLAVVVTPGQAHDGQSLQLLLGDLRVPRTGAGRQRTTPTMLLGDKAYSSRAIRAALKARGITAVIPERRDQQEHRRRRGSAGGRPSKFDPVAYKNRNVVERSFALLKQWRGLATRFDKLAIVYRSAAALAAVLVWARI
>NC_015957.1|WP_014053670.1|126130_126457_+|hypothetical-protein
MPSVEGVRGLLARYVTGRLEDGSVCLEVLGLEVIDQGRRFTVAVELIAPDGHWRVRLECDSAEHRIFDGSPPEDLVQAVAMSLRIRLFEWWHTKGSERQSARLGERVD
>NC_015957.1|WP_014053678.1|133660_134761_-|AMP-binding-protein
MPTASLSVLDVPFDERPDPDEYIRAAMEWHFGPDTGSPFWLRKARTLDFDPRRDVKGVADLALFPNVTGELRDVPVRDLIPQGYGADARIVGVFESGGTTGAPKRIVCLRDWLDRLTHGLSADLDGLGIPRGVDWLAIAPSGPHMVGEMVAGTAARHGGLMFRVDMDPRWVKKLISAGKAEETDAYVSHLVEQAAYVLRTQDIGVLMTTPPLLERLARHDDLIELIGEKVKGIMWGGAHMDADTRDLLRNEVFPGCALYGTYGNTMILGGATERLGLGPDEPCVFDPRTPFVTFSVVDPASGEPVPYGERGQVVMNHVSKSALLPGNLERDLAIRVPPPEGAAGDSVADVGPVAMFDDEVVIEGVY
>NC_015957.1|WP_043237564.1|134902_136267_-|aldehyde-dehydrogenase-family-protein
MQALDALGPKGPYRSRHRLTISDVTGTPMAELSLVPRLFVTRALAALRAAATPPLEERLAALKRAGELFATGTVAGMTAAAYESAVCRMSGTPLANVRIAVEAIRLSATEAYRSVQAARPVGAVGDWRDPYARSGTAVWIRRGDVFAVHAAGNHPAVHALWLEALALGYRVAVRPSRREPLTPYRLVGALREAGFGTDQVVLLPTDHDAAGEILHGADLSMVYGGQEVIDRYATDPAVLPNGPGRSKILLTADRDWRDHLDVVVDSIARHGGTACVNATAVLVEGDPAPVAEALAERLAALPSLPPQDEKAVLPVHPLEVARGFERLLLGKAAGARAWLGGDGVVDDLGDGSAALRPAVFQLDDPRDPRLGMELSFPCVWVAPWTRAAGVAALRDSLVVTAITGDEALLDALLAEPSVKNLYIGDHPTHWIAPGIPHDAYLGEFLMRTKAVIRG
>NC_015957.1|WP_014053680.1|136564_137284_+|response-regulator-transcription-factor
MGETGGGRVLVTDDDAAIRRSLERGLRLNGFSVTLADGGHAALAAVRDGAPDVVVLDISMPDLSGIEVCRALRGDGNDVPVLMLSALDEVSDRVAGLQAGGDDYLVKPFALQELVLRLHALLRRRPPAATDRVRAGALEMAPEAQGAWLDGTPLRLTRREFELLDTFARNAGIVLTRDQLLDRVWGYDFEVRTDAVDTFVSYLRRKLEAGGRPRMLHTVRGVGFVLRPSGPPEGRPTGP
>NC_015957.1|WP_014053681.1|137467_137893_+|hypothetical-protein
MHRGKSVIVACAATAALLGPVGVAAADGSAPASTPAAAPSAKPHKGAGDGSQGLCKRSKKIDKRLDRALKRLKGQASVKGSVARLAKRVERAKKADHTEVETFLNHKLTFRRSLVTTLEQRQKDLSKVQTWCASRGAGSGT
>NC_015957.1|WP_014053682.1|137889_138150_+|hypothetical-protein
MRRGRPVRRGPWAVAATAVLCAALATGCGGGKGGGSDDADGSDGSSGSSSAPSATAPAPSTSELNKLVDDAESAADKADSDAASDN
>NC_015957.1|WP_106685818.1|138675_139734_-|hypothetical-protein
MYVDGEGLPGALAGGVIGWGAHLYLARRRALAERAPGTAPSARAAAPTAHAVRAPLWERLRDRVLDVIGARRSRRAGDAGGRAGAGGRAGAGGRAGAGGADGGGASRSGGHRVSRSRASRRRLRRARTTVILAVIAIVALATLVTLTRTAADSDDRSNGYLGPEETPSLAPATSSPNNPGASASPSPSKGGSDAKDPGEGSGHDPGKGSTRKPGRSPSAAPAPSRGDSDSGSASGHGGRRPSDRRPGAYADCTARFQLVTEWPEGFKAAVTLTSRKPLDDWRVTWTFRDSQRVTQMWDGDFTQHGSKVTATAADYNKRVKAGGSLSVGFLGTWNDGNRPPGSFTLNGRPCAD
>NC_015957.1|WP_014053685.1|140942_141863_+|dihydrodipicolinate-synthase-family-protein
MPEIPGVSAPWRGVHVATALPFHDDDELSVDYEGYAAHVRFLAEHGCDGVCPNGSLGEYQTLTDEERARVVRVAVEAAPEGFGVMPGVAAYGALESRRWAEQAREAGARAVLALPPNSYRADREAVVGHYREVARAGLPVVAYNNPHDTKVDLTPELLAELHGEGLIVAVKEFSGDVRRAYEIAERSPGLDLLIGADDVLLELGLAGAVGWIAGYPNAIPEATVELYRLATSGVGTDLEKALPLYRALHPLLRWDSRTEFVQAIKASMDLAGLRGGSCRPPRSRLTGEVAARVVRETETVLGLGYR
>NC_015957.1|WP_014053686.1|141965_142967_+|proline-racemase-family-protein
MRSRRVLHTVESHTEGMPTRVVTGGVGTLPGATMAERRRWFIEHQDDLRTLLMYEPRGHSAMSGAILQPPTRPDADHGVLFIEVSGVLPMCGHGTIGVATVLVETGMVEVCEPVTTIRLDTPAGLVVADVAVRDAAATSVTIRNVPSFCLATDRTVRVPGFGEVRYDIAFGGNFYAIVELGALGLPFDRAAGQELLTAGLKIMEAVNAQDPPHHPERPDITGCHHVYLKAPGSTARHSRHAMAIHPGWFDRSPCGTGTSARMAQLYARGELGLGEEFVNESFIGTRFIGRLLEETTVAGLPAVVPAITGRAWVTGTAQFHLDPDDPFPAGFLM
>NC_015957.1|WP_043237568.1|143051_144254_+|FAD-binding-oxidoreductase
MAEELPSTADLVVIGAGVVGAAAAWFAALAGLRVVVVDRGAVAGGTSGAGEGNVLVSDKEPGPELELAQYSRQVWGEDLGAYGGLWEFESKGGLVVAFTPTALGALQTLAERQRACGVDVREVSGAELPALEPRLTREAAGGALYPQDAQVQPMLAAAHLLRLARRRGAVVRTRTEVVGFLRPGGGRPGGGHAGSPVTGVRTPHGTVSAPAVLNAAGTWAGAVAGLAGVELPVLPRRGFVLVTEPLPPATVRHKVYSADYVDAVASSDAELQASPVVEGTGGGTVLIGSTRERVGFDRRPSPAALRALARGAIGLFPVLASVRAMRVYAGFRPYCPDHLPVIGPDPRAPGLWHACGHEGAGIGLAAGTGKLIAQALTGEATELDLTPFAPERFASEGGRG
>NC_015957.1|WP_078505056.1|144250_145054_+|(2Fe-2S)-binding-protein
MSHAGSEPVVGTGSPPYRLTFDGTTVTALPGQSVGAALVAAGIVAWRTTRREGRPRGLFCGIGVCFDCLITVDGRPNQRACLVPARDGMRLSAEGDGVGGGDDGGAGAGAGARDSAGGGGDDAARGGAGGGASAGASAGGGGGGGGGDAARGGAGDRGGERAGGSGGGGDAARDGDRGRDGDRGGAGDRGAARGGASASATAGASAGGGGGAGDRGGEGAGGSDAARDGDRGCDGDRARDGDRGRDGDRRGVDSRVDGEGGGDGDVD

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Crispr_ID: NC_015957_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015957_2

266086-266184

Orphan

Consensus_repeat	Method
CGGGCGAGTCGTCCGGTACGGAGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015957_2

>merge|NC_015957|2|266086-266184|CRISPRCasFinder
CGGGCGAGTCGTCCGGTACGGAGTCGGGTGATCCGACCGGTGCCGGGGCCGAGTCGACTGGGCCCGAGCCGGCTGCGGCCGAGTCGTCCGGTACGGAGT

>NC_015957|2|2|266086-266184|CRISPRCasFinder
CGGGCGAGTCGTCCGGTACGGAGT	CGGGTGATCCGACCGGTGCCGGGGCCGAGTCGACTGGGCCCGAGCCGGCTG
CGGCCGAGTCGTCCGGTACGGAGT

Protein	Signature genes	Signature genes Name	Protein_function
NC_015957.1\|WP_106685823.1\|260524_261064_+\|orotate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234771
NC_015957.1\|WP_050993873.1\|265090_265885_+\|tryptophan-2,3-dioxygenase	unknown	unknown	gnl\|CDD\|188272
NC_015957.1\|WP_014053808.1\|275262_276180_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NC_015957.1\|WP_043237641.1\|266468_267677_+\|kynureninase	unknown	unknown	gnl\|CDD\|226363
NC_015957.1\|WP_078505061.1\|255367_255658_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|215598
NC_015957.1\|WP_014053798.1\|261240_262263_+\|class-II-fructose-bisphosphate-aldolase	unknown	unknown	gnl\|CDD\|236406
NC_015957.1\|WP_043235225.1\|258691_259588_+\|carbon-monoxide-dehydrogenase-subunit-G	unknown	unknown	gnl\|CDD\|176865
NC_015957.1\|WP_014053796.1\|259613_260429_+\|aldose-1-epimerase	unknown	unknown	gnl\|CDD\|185698
NC_015957.1\|WP_014053800.1\|264208_264622_+\|DUF3151-domain-containing-protein	unknown	unknown	gnl\|CDD\|378646
NC_015957.1\|WP_014053799.1\|262375_264082_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NC_015957.1\|WP_043235229.1\|276281_276827_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224427
NC_015957.1\|WP_014053805.1\|271083_271779_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NC_015957.1\|WP_014053807.1\|273613_275266_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226089
NC_015957.1\|WP_014053793.1\|256101_256692_+\|DUF2617-family-protein	unknown	unknown	gnl\|CDD\|378512
NC_015957.1\|WP_014053806.1\|272239_273466_+\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035
NC_015957.1\|WP_014053803.1\|267680_268565_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223730
NC_015957.1\|WP_078505649.1\|269728_271087_+\|two-component-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NC_015957.1\|WP_014053811.1\|277536_278562_-\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014053794.1\|256811_258407_+\|polyamine-aminopropyltransferase	unknown	unknown	gnl\|CDD\|235139
NC_015957.1\|WP_014053812.1\|278776_280060_+\|adenylosuccinate-synthase	unknown	unknown	gnl\|CDD\|234904

Protein	Function_ID	Function_description	E-value
NC_015957.1\|WP_106685823.1\|260524_261064_+\|orotate-phosphoribosyltransferase	gnl\|CDD\|234771	PRK00455, pyrE, orotate phosphoribosyltransferase; Validated.	6.3992e-62
NC_015957.1\|WP_050993873.1\|265090_265885_+\|tryptophan-2,3-dioxygenase	gnl\|CDD\|188272	TIGR03036, trp_2_3_diox, tryptophan 2,3-dioxygenase. Members of this family are tryptophan 2,3-dioxygenase, as confirmed by several experimental characterizations, and by conserved operon structure for many of the other members. This enzyme represents the first of a two-step degradation to L-kynurenine, and a three-step pathway (via kynurenine) to anthranilate plus alanine. [Energy metabolism, Amino acids and amines].	1.58586e-140
NC_015957.1\|WP_014053808.1\|275262_276180_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	6.69046e-85
NC_015957.1\|WP_043237641.1\|266468_267677_+\|kynureninase	gnl\|CDD\|226363	COG3844, COG3844, Kynureninase [Amino acid transport and metabolism].	3.70615e-138
NC_015957.1\|WP_078505061.1\|255367_255658_+\|hypothetical-protein	gnl\|CDD\|215598	PLN03138, PLN03138, Protein TOC75; Provisional.	5.03313e-07
NC_015957.1\|WP_014053798.1\|261240_262263_+\|class-II-fructose-bisphosphate-aldolase	gnl\|CDD\|236406	PRK09197, PRK09197, fructose-bisphosphate aldolase; Provisional.	0
NC_015957.1\|WP_043235225.1\|258691_259588_+\|carbon-monoxide-dehydrogenase-subunit-G	gnl\|CDD\|176865	cd07823, SRPBCC_5, Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins. Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	1.33617e-22
NC_015957.1\|WP_014053796.1\|259613_260429_+\|aldose-1-epimerase	gnl\|CDD\|185698	cd09021, Aldose_epim_Ec_YphB, aldose 1-epimerase, similar to Escherichia coli YphB. Proteins similar to Escherichia coli YphB are uncharacterized members of the aldose-1-epimerase superfamily. Aldose 1-epimerases or mutarotases are key enzymes of carbohydrate metabolism, catalyzing the interconversion of the alpha- and beta-anomers of hexose sugars such as glucose and galactose. This interconversion is an important step that allows anomer specific metabolic conversion of sugars. Studies of the catalytic mechanism of the best known member of the family, galactose mutarotase, have shown a glutamate and a histidine residue to be critical for catalysis; the glutamate serves as the active site base to initiate the reaction by removing the proton from the C-1 hydroxyl group of the sugar substrate, and the histidine as the active site acid to protonate the C-5 ring oxygen.	4.67249e-60
NC_015957.1\|WP_014053800.1\|264208_264622_+\|DUF3151-domain-containing-protein	gnl\|CDD\|378646	pfam11349, DUF3151, Protein of unknown function (DUF3151). This family of proteins with unknown function appears to be restricted to Actinobacteria.	2.62553e-74
NC_015957.1\|WP_014053799.1\|262375_264082_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.98238e-77
NC_015957.1\|WP_043235229.1\|276281_276827_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|224427	COG1510, COG1510, Predicted transcriptional regulators [Transcription].	1.62043e-09
NC_015957.1\|WP_014053805.1\|271083_271779_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.5976e-74
NC_015957.1\|WP_014053807.1\|273613_275266_-\|ABC-transporter-permease	gnl\|CDD\|226089	COG3559, TnrB3, Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane].	9.37626e-115
NC_015957.1\|WP_014053793.1\|256101_256692_+\|DUF2617-family-protein	gnl\|CDD\|378512	pfam10936, DUF2617, Protein of unknown function DUF2617. This bacterial family of proteins has no known function.	5.61834e-64
NC_015957.1\|WP_014053806.1\|272239_273466_+\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	6.05997e-104
NC_015957.1\|WP_014053803.1\|267680_268565_+\|alpha/beta-hydrolase	gnl\|CDD\|223730	COG0657, Aes, Esterase/lipase [Lipid metabolism].	2.11162e-16
NC_015957.1\|WP_078505649.1\|269728_271087_+\|two-component-sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	2.54305e-35
NC_015957.1\|WP_014053794.1\|256811_258407_+\|polyamine-aminopropyltransferase	gnl\|CDD\|235139	PRK03612, PRK03612, polyamine aminopropyltransferase.	0
NC_015957.1\|WP_014053812.1\|278776_280060_+\|adenylosuccinate-synthase	gnl\|CDD\|234904	PRK01117, PRK01117, adenylosuccinate synthetase; Provisional.	0

>NC_015957.1|WP_050993873.1|265090_265885_+|tryptophan-2,3-dioxygenase
MDFDGTTPYEDYVQASVLTHLQRPLSDDPGEMVFLVTTQVMELWFTVIVHEWHTAAQALREDDLPTAMAALQRSAYELESLNASWTPLAHLTPGQFNAYRSALGEGSGFQSAMYRRLEFLLGEKSASMLVPHRGAPRVHAELEKALTEPSLYDEVLRYLARRGLAVPAAVLDRDPALRYEPDPGVERVWEEIYSGPREGELVRLGEALTEVAELVWRWRNDHLVATRRAMGAKTGTGGSAGVAWLEKRAGKTVFPELWTARSHV
>NC_015957.1|WP_014053800.1|264208_264622_+|DUF3151-domain-containing-protein
MAIHENLLGGPPPTHLPDDPEPRELLASGAAPSEVAAKYPASSLAWAQLADEAFEAGRVVESYAYARTGYHRGLDSLRRSGWKGHGPVPFEHEPNRGFLRALHALARAAQSIGEQEEYERCSTFLRESSPTAADTLS
>NC_015957.1|WP_014053799.1|262375_264082_+|MFS-transporter
MGGATPGADRAPGNGQPVRLSVPAGRWLVFTTVLGSAMALLDSTVVNVALPRIGLDLGADLPVLQWTVNAYMLTLAGLILLGGALGDRFGRRRVFVIGVVWFSLASLACGLAPNAGVLIAARALQGIGGALLTPGSLALIQSVIHPDDRARAIGLWSGFGGVGAAIGPFLGGWLVDGPGWRWVFFINVPLAAVCVPVALRHVPETSNPRAHGRFDVLGALLGAATLGLITYALIAAPQKGPSPAVVVPAVAGLALGMVFVAVERRRHEPMLPLSIFSSHQFSAVNAVTLCVYAAFGGFFFLSVLDLQVVVGYSALAAGTALLPTTTLMLLLSARSGELGKRIGPRIPLTVGPLLCAAGMLLMTRAGVGAVYWRDILPALLVLGMGMVVVVAPLTATVLASVDVARAGLASGVNNAAARAAGLIAVAALPLLAGMGPEAYRSADAFGDTFRRAMPICAGVLVLGAVLAWRTVRSDALEPVGLEPTGLEATGLEAGAGVGAEAGAEVGPAPERAEPAAVPAERAEGAVRPEGLLCRPECAYHCGVAAPPLDPGDVSTPPPLNPGERRSDT
>NC_015957.1|WP_014053798.1|261240_262263_+|class-II-fructose-bisphosphate-aldolase
MPIASPEIYNEMLDRAKAGKFAYPAINVTSTQTLHAALRGFAEAESDGIVQISTGGAEFLGGQYSKDMVTGAVGLAEFAHVVAEKYPVHIALHTDHCPKDKLDGYVRPLLKISQERVANGQNPLFQSHMWDGSAETLDDNLRIARELLAEAVKAKIILEVEITPTGGEEDGVTHEINDKLYTTVDDALRTAEAIGLGDKGRYLLAASFGNVHGVYKPGNVVLRPELLRELQDGVAAKYGKPDPFFFVFHGGSGSSEEEIRTALENGVVKMNLDTDTQYAFTRPIADHMFRNYDGVLKVDGEVGNKKHYDPRSWGKLAEKGMSERVTQACANLRSTGTKLK
>NC_015957.1|WP_106685823.1|260524_261064_+|orotate-phosphoribosyltransferase
MSDARDALLQQIKDKAVVHGKVTLSSGREADYYIDLRRITLDAEAAPLVGQVMLEATADLEYDAVGGLTLGADPVATSMLHAAAAHGRRLDAFVVRKAQKTHGMQRRIEGPDIAGRRVLVVEDTSTTGGSPLTAVEAAREAGAEVVAVATIVERGAAPAIADAGLPYLPAYSLADLELS
>NC_015957.1|WP_014053796.1|259613_260429_+|aldose-1-epimerase
MTTEETPETKGVRLTAGDAELTVSPENGCRIGSLRIGGTELLRQGPRFGAFPMVPWCGRTGLGRFRNGGQTHQLPINSPPHAIHGTGRNVAWSQVRSGQSSAAFTYDLADPWPYEGRVTQTFELSPDSATVTMSVETEGDSFPAQAGWHPWFLRNLGDGGADAEIAFDAAWQEERGEDHLPTGRRIAPKPGPWDDCFGMPQGVDVTLTWPGRLELKVTSRTEWVVVYDEQAEAVCVEPQSGPPNGLNLLPRLVTPIDPLELSMTWSWRTLA
>NC_015957.1|WP_043235225.1|258691_259588_+|carbon-monoxide-dehydrogenase-subunit-G
MEHEVFVPFPVDTVRLALAEPDRVARCVPGLQRDADEAAGPLSGRLRLRIGGSTITYRGVLRVGRRADVFEIEGEGTEARGSGSVKLALTVTPKPVEGGTELSCAGTVHSEGRLAEFDDEASTTVARRMLDRFASTLTAGLQTSPITAATEDEAPGRPTDEAGDGDADAGTAAAAEESGLPTEAELPLSADDMDIDDVGDLEDVDDADAVEEPVGFGNLADLDDLDDEPPAEAAHARRTMIGRSTEEVDHAPPRGRYAPVPAPQTVSTSATLRWAAPAAAVVLASVVVVGRRVLRRRR
>NC_015957.1|WP_014053794.1|256811_258407_+|polyamine-aminopropyltransferase
MSAVSDAPSSPESGPPARLPVRAALGRFLVLGSVFVCAACGLVYELELVALASYLAGDSVTQASVVLSVMVFAMGVGSLLAKRLRCRAAVGFGAVEAVLALVGGCSAMALYACFAWGGHSRSALVGFSFAIGVLIGAEVPLLMTLIQRVRRQDAGGAVADLFAADYVGALVGGLAFPFLLLPAFGELTGALVTGAVNAVAGGALVLWLFRRDLSVRARWTLIVANGLVLAALTAGAVLTPSFERAARQAVYGPGVRVALHTGEQEIVLVGGGTSGRPLALFVNGRLRVSGRDEARYHEALIHPAMAAGPHGRVLVLGGGDGLAAREVLRYPGVRSVTVVERDAEVARLARRDPGLSELNGGAYRDPRVRAVTADAFDWLRRSMAYDVVVCDLPARELTPSTKYYSQEFYGLAERVLAPGGRLVVHAGPLRPDPRAFWTVDATMRSVGLRTAPYVIDTPRPGRGSPRPGRGSPHDWGFVLAARSPVGLRLASHDPRPRSLTEEGLRAARRRAERHREAGLPPSTLMHPRYGE
>NC_015957.1|WP_014053793.1|256101_256692_+|DUF2617-family-protein
MLTTLKTAYTDTRAADLAWGLGREPLPALAVLDLQLHGFDVQLRLLGASHQVLLEGEGSRCSETVACMSGNSTALPLGVSTLVDGREYEFAARVEELSQGAFAGRAQELLALVADHPHGLAGTFPGSPNAFTALLAQWHEGTVGWRTWHAYPQEGRLVTTRTCVGARVPAALRPPGAGGLEIGGLPDGRSPQVPCA
>NC_015957.1|WP_078505061.1|255367_255658_+|hypothetical-protein
MGPVVILVVVAFTFAALAALGAGRSKGYSGRRKRSWSAGSGGAAGGSWWAGGDGGGGHHGGGHHGGGGCGGGSGCGGGGGGGCGGGGGGGGCGGGA
>NC_015957.1|WP_043237641.1|266468_267677_+|kynureninase
MSRSALSDEATTLDAADRLRAKRDAFTLDDVIYLDGNSLGALPRAVPSRLADVVAREWGELRIRSWEESGWWTAPERVGDRVGGLVGAAPGQVVVGDSTSVNVFKAVVAAVRMAQERGAHRDQILVDETTFPTDGYIAESAARMTGCTLRPVAAGDVPSAVGARTAVALVNHVDYRTGRLNDLPGTTAAVQAAGGLVVWDLCHSAGALPVGLDAHGVDLAVGCTYKYLNGGPGAPAYLYVARAHQPRFDSPLPGWNSHADPFGMASAYTPADGSARGRVGTPDILSMLALEAALEVWDDVTIEDVRAKSLALTDFFLRCVEDYVPAGRVQSVTPAAHTERGSQVALRCADAGEVMAELTRRGVVGDYRRPDVLRFGFTPLYTGFAEVERAARVLADVLLKEG
>NC_015957.1|WP_014053803.1|267680_268565_+|alpha/beta-hydrolase
MGGAAAEETSVLGLTPVAPDRTAAYGEHPDQVADFYLPRGSRGPRGAARPAPLVLLFHGGAWRAPYDRRHVSPFAAFLAGRGLAVASVEYRRGGAEPARAGRWPETFDDIAAAVDTVPGLARELGLPGADPDRVVLTGHSAGGHAVLWAAARHRLPSGTPWHLPSPSPLRGVVALAPIADLATARALDVCSGAVGELLGELGGDGDELTARLALADPAALLPTAIPTTIVQGGTDIDVPPAVADAFATAATRAGQDVRLVRTEGGHFPPIDPTTPVAHTVAEEIAHVAGTGPAR
>NC_015957.1|WP_078505649.1|269728_271087_+|two-component-sensor-histidine-kinase
MITGAFAFRPVPPLAATHPLVRHMPRAVRPYAPWLPQAAIVACAFYLMAVAGETEGAALALLSGVPLLLALYRPIGAWWLSFAASLVWGLGGADMYGGSMWPWPTTLFASHIAVMVIVATQNRPRVAGRMLLLTAGFGFACELGINARPTNAFPMVVASCVIVGAVVARRSLRETKQQVAVQQSATYEERSRRTLLEERATIARELHDVVAHHMSVIAIQAEAAPYRVANPPEELATSFATIRENAVAALTELRRVLGVVRADDPDAYADADPEAPQPTLATLDTLFAGVRAAGLTVEHVITGAVRPLPSGVELSAYRIVQEGLSNALRHAPGSTARVEIAYVLGGLGLRIVNGPPTQPVRPSPGMGHGLLGMRERVAMLNGEMTAGTVEEDGGYEVAVFIPAAALPEAEASGSFGSSGPSGSSGSSGSEASGPAAPGLTKGPAPEGETMKP
>NC_015957.1|WP_014053805.1|271083_271779_+|response-regulator-transcription-factor
MTTDVPPPIRVLIADDQVMVREGFSVLLNAQPDIEVVGEAVDGRQAIAQVAALRPDVVLMDIRMPELNGLEATREIVAADADAKVLVLTTFDLDEYVYQALRSGASGFLLKDASARQLGEAVRVVAAGEALLAPTVTKRLITTFSRIGEAAGLGGPLPSPQGRLAELTERENEVLVLVAQGCSNAEIAERLIVAESTVKTHVSRILVKLGLRDRTQAAVFAYEARLVTPGG
>NC_015957.1|WP_014053806.1|272239_273466_+|cytochrome-P450
MSSSRAEAPAFDPWQPSFVADPYPAYAALRERGRVHWFEPSRQWLIPRHADVSALLRDRRLGRTYLHRFSHEEFGRTAPPPEHEPFHTLNDHGMLDLEPPDHTRLRRLVSKAFTPRTVEALVPTIRRFADELVDSLVASGGGDLIAAVAEPLPVAVIAEMLGIPPADRPALRPWSADICGMYELGPSEETARRAVRASLEFSGYLRELIGARRKAPGDDLISGLIAAHDEGDRLTEQEMISTCVLLLNAGHEATVNSTGNGWWALFRHPEQLARLRAEPDALLPTAVDELLRFDTPLQLFERWVLEDIEVDGTAIPRGSEVALLFGSANRDPARFDRPDALDLSRADNPHVSFGAGIHYCLGAPLARLELAASFGALLRKAPGMRLVKEPEPQANFVIRGLRELLVEL
>NC_015957.1|WP_014053807.1|273613_275266_-|ABC-transporter-permease
MTAVADARVSPRTRGSARDLAGTGTLLRLALRRDRIMMPVWVLCLGLTASSTVGRLKSAYDTPARRANLVHDMNGNGSTRALFGAAFDDSLGALTVWRVGAFLTVFAAIMSLLIVIRHTREEEETGRQEALSAGMVGRRAGLTSALLAVGIANGAVTLLIAGGLAGQGGTGALALGLAVGLSGMAFGGLAAVAAQLTENARLARGLSSAAVGVAFVLRMAGDAAEDGTKGSGHVLVWLSPLGWAEYARPYGGERWWPLLLIAVLAAASISLAYSLAGRRDVGASFYASRPGPPAAGPLLNGVYGLGWRLQRGALLGWAAGFVFAGAIFGSISDGADDFLGDSNQTRDIIQRMGGAQGLNDAFLAAMVGVLGTILTVYTASSVLRLRSEETDQRAEPLLSNAVGRLRWAGSHLVIAYLGPAVILAIGGLALGLGYGVAAGDLADQLGRCMGAALAQLPALWVLTSVTLFLVGVLPKYSAAAWAFVGWVVALGWMGPALELSDSVMNTSPFSHLPKLPGDEVTAAPFLWLLLLSVVLAAGGLVGLRRRDIGG
>NC_015957.1|WP_014053808.1|275262_276180_-|ABC-transporter-ATP-binding-protein
MKTAISVSGLHKSFGRTHALDGLDLEVEAGEVHGFLGPNGAGKSTTIRVLLGLLRADSGAVQMLGKDPWHDAVDLHRHIAYVPGDVTLWRNLSGGEVIDLYGRLRGGLDSARRAELLERFELDPTKKGRTYSKGNRQKVALVAAFASEVELLILDEPTSGLDPLMEEVFRECVAEERDRGRTVLLSSHILSEVEALCRRVSIIRKGKRVESGSLTELRHLTRTSVTAELAEEPNGLSGLPGVHNVDIQGRQVKLQVDTDKMDAVLRQLTQAGVRSLISTPPTLEELFLRHYQDDISHTEAEAIVR
>NC_015957.1|WP_043235229.1|276281_276827_+|MarR-family-transcriptional-regulator
MIEPEDAPGDARDETAVSRFVERFAADLAEAGMQRMAARVFAALLVSDAGALTSAELAEQLRISPAAVSGAIRYLAQVDMVVREREPGSRRDRYRLYSEVWYETLTRRDQMMARWESTMRDGVKVLGPGTPAGLRITETADFFEFVQQELPKMLERWRVHQAADRAAEAREAREAREAEAG
>NC_015957.1|WP_014053811.1|277536_278562_-|hypothetical-protein
MVIDPNARRTDGESVRIAKDVLCAGAQTKICLPDGPEEVERALARRGARRPVLVGDDRALLRMVELLHRRRELADATLSVVPVGGSATVALAHSLGVPTDAVAAARTVLDGTARPRDLLVDESGGVVLGGLRIPSGRASYGAHGTPGGGCGAAAGADGHDPGPHDGGARGRDCRCDPCDRDRRRRAEEDGDGGGGGDGGGPPGGDPDGDGNQPWWTPAARTARTALTLLSLPVIGLAGGARRPAHPPPQRLRIEADGVLLTDLDRPVERVSVSTAAPGGGLAEVVVHPHAADGPLRTRARAVTVSGPDFRYHADALIRGPVRSRTWTVLAEAWSLMLPHRP
>NC_015957.1|WP_014053812.1|278776_280060_+|adenylosuccinate-synthase
MPALVLLGAQWGDEGKGKATDLLGGSVDYVVRYQGGNNAGHTVVVGDQKYALHLLPSGILSPGCTPVIGNGVVVDPAVLLSELSGLDERGVDTSKLLISGNAHLITPYHTTLDKVSERFLGKRKIGTTGRGIGPAYADKINRVGIRVQDLFDESILRQKVEAALDHKNQVLAKLYNRRAIAVDQVVEELLGYADPLSGYVADTTLLLNNAIDQGQVVLFEGGQGTLLDVDHGTYPFVTSSNPTAGGACTGTGVGPTKINRVIGILKAYTTRVGAGPFPTELLDEDGEKLRTIGGERGVTTGRDRRCGWFDAVIARYATRVNGLTDFFLTKLDVLTGWERIPVCVAYEIDGKRVEELPYSQTDFHHAKPIYETLPGWSEDITQAKTFDELPKNAQKYVQALEEMSGAPISAIGVGPGRDETIQINSFL

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Crispr_ID: NC_015957_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015957_3

474384-474521

Orphan

Consensus_repeat	Method
GATGCGATCCCAGCCCCTCCGGCGTTTGAGGAGCGGGGTCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015957_3

>merge|NC_015957|3|474384-474521|CRISPRCasFinder
GATGCGATCCCAGCCCCTCCGGCGTTTGAGGAGCGGGGTCCTGGGGCGGAGCCCCGGCGGGGGCCGGGCCGGGCCCCACGCGGCGGAGCCGCACATTGATGCGATCCCAGCCCCTCCGGCGTTTGAGGAGCAGGGTCC

>NC_015957|3|3|474384-474521|CRISPRCasFinder
GATGCGATCCCAGCCCCTCCGGCGTTTGAGGAGCGGGGTCC	TGGGGCGGAGCCCCGGCGGGGGCCGGGCCGGGCCCCACGCGGCGGAGCCGCACATT
GATGCGATCCCAGCCCCTCCGGCGTTTGAGGAGCAGGGTCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015957.1\|WP_106685828.1\|465754_466366_-\|SigE-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|132028
NC_015957.1\|WP_078505073.1\|477117_477963_+\|sugar-phosphate-isomerase/epimerase	unknown	unknown	gnl\|CDD\|224007
NC_015957.1\|WP_106685610.1\|485777_486200_-\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_106685609.1\|465041_465767_-\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014053970.1\|467854_468718_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|180777
NC_015957.1\|WP_014053972.1\|470662_472087_-\|DNA-repair-protein-RadA	unknown	unknown	gnl\|CDD\|236994
NC_015957.1\|WP_014053977.1\|477959_478589_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380054
NC_015957.1\|WP_043235279.1\|481140_483471_-\|PQQ-binding-like-beta-propeller-repeat-protein	unknown	unknown	gnl\|CDD\|270916
NC_015957.1\|WP_014053964.1\|462490_462958_+\|glyoxalase	unknown	unknown	gnl\|CDD\|319924
NC_015957.1\|WP_014053973.1\|472344_474063_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274357
NC_015957.1\|WP_043235274.1\|478807_480658_+\|dihydroxy-acid-dehydratase	unknown	unknown	gnl\|CDD\|237104
NC_015957.1\|WP_014053974.1\|474700_475573_-\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014053975.1\|475744_476674_+\|Ppx/GppA-family-phosphatase	unknown	unknown	gnl\|CDD\|223326
NC_015957.1\|WP_078505076.1\|480641_481103_-\|PQQ-binding-like-beta-propeller-repeat-protein	unknown	unknown	gnl\|CDD\|274511
NC_015957.1\|WP_014053965.1\|462962_464318_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NC_015957.1\|WP_014053969.1\|466592_467519_-\|A/G-specific-adenine-glycosylase	unknown	unknown	gnl\|CDD\|224115
NC_015957.1\|WP_014053980.1\|483617_483953_+\|SH3-domain-containing-protein	unknown	unknown	gnl\|CDD\|227324
NC_015957.1\|WP_014053981.1\|484043_485600_-\|SulP-family-inorganic-anion-transporter	unknown	unknown	gnl\|CDD\|223732
NC_015957.1\|WP_043235269.1\|464324_465032_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_015957.1\|WP_050993876.1\|469112_470171_-\|DNA-integrity-scanning-protein-DisA	unknown	unknown	gnl\|CDD\|237395

Protein	Function_ID	Function_description	E-value
NC_015957.1\|WP_106685828.1\|465754_466366_-\|SigE-family-RNA-polymerase-sigma-factor	gnl\|CDD\|132028	TIGR02983, putative_RNA_polymerase_ECF-subfamily_sigma_factor, RNA polymerase sigma-70 factor, sigma-E family. This group of similar sigma-70 factors includes the sigE factor from Streptomyces coelicolor. The family appears to include a paralagous expansion in the Streptomycetes lineage, while related Actinomycetales have at most two representatives.	1.54044e-57
NC_015957.1\|WP_078505073.1\|477117_477963_+\|sugar-phosphate-isomerase/epimerase	gnl\|CDD\|224007	COG1082, IolE, Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism].	4.15912e-28
NC_015957.1\|WP_014053970.1\|467854_468718_+\|hypothetical-protein	gnl\|CDD\|180777	PRK06958, PRK06958, single-stranded DNA-binding protein; Provisional.	1.80333e-07
NC_015957.1\|WP_014053972.1\|470662_472087_-\|DNA-repair-protein-RadA	gnl\|CDD\|236994	PRK11823, PRK11823, DNA repair protein RadA; Provisional.	0
NC_015957.1\|WP_014053977.1\|477959_478589_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|380054	pfam17920, TetR_C_16, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. This entry represents the C-terminal domain found in a number of different TetR transcription regulator proteins found in Actinobacteria. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain.	1.86856e-30
NC_015957.1\|WP_043235279.1\|481140_483471_-\|PQQ-binding-like-beta-propeller-repeat-protein	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	3.60759e-85
NC_015957.1\|WP_014053975.1\|475744_476674_+\|Ppx/GppA-family-phosphatase	gnl\|CDD\|223326	COG0248, GppA, Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism].	3.30393e-83
NC_015957.1\|WP_014053973.1\|472344_474063_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	6.16719e-06
NC_015957.1\|WP_043235274.1\|478807_480658_+\|dihydroxy-acid-dehydratase	gnl\|CDD\|237104	PRK12448, PRK12448, dihydroxy-acid dehydratase; Provisional.	0
NC_015957.1\|WP_014053964.1\|462490_462958_+\|glyoxalase	gnl\|CDD\|319924	cd07263, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	1.60822e-34
NC_015957.1\|WP_078505076.1\|480641_481103_-\|PQQ-binding-like-beta-propeller-repeat-protein	gnl\|CDD\|274511	TIGR03300, assembly_YfgL, outer membrane assembly lipoprotein YfgL. Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking].	5.0078e-06
NC_015957.1\|WP_014053965.1\|462962_464318_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	6.84892e-34
NC_015957.1\|WP_014053969.1\|466592_467519_-\|A/G-specific-adenine-glycosylase	gnl\|CDD\|224115	COG1194, MutY, A/G-specific DNA glycosylase [DNA replication, recombination, and repair].	8.94181e-85
NC_015957.1\|WP_014053980.1\|483617_483953_+\|SH3-domain-containing-protein	gnl\|CDD\|227324	COG4991, COG4991, Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown].	9.07196e-07
NC_015957.1\|WP_014053981.1\|484043_485600_-\|SulP-family-inorganic-anion-transporter	gnl\|CDD\|223732	COG0659, SUL1, Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism].	2.94905e-89
NC_015957.1\|WP_043235269.1\|464324_465032_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.87981e-80
NC_015957.1\|WP_050993876.1\|469112_470171_-\|DNA-integrity-scanning-protein-DisA	gnl\|CDD\|237395	PRK13482, PRK13482, DNA integrity scanning protein DisA; Provisional.	0

>NC_015957.1|WP_014053973.1|472344_474063_+|sigma-70-family-RNA-polymerase-sigma-factor
MSSRSEHSTQTTGAQRVRRRAPRSTTTRPQRPPERYEPYLDGLFTYCLSALCEHDAAAVAVGDVLAVAERRPGRGRGRVTAEGELSRPWLYAVARWACLRKLAERRGRTGTDTPGDGAGAELPEPIAAQRRRELAALAWPEAAGTSAEQREALELAVRHRLGPSEVAAVLGKDQEETRALLSSAACEVERTRAALAVVELGHCPVVARLAGDTQVLLSAALRRELVRHVDDCRECRRIAERATADGPWPGTAAAPAALPVVEAPRAAVHAALLSALSGRPARAGAGPRFDRRGFPLEPQDRAARRSRMRSRALTTTVVATVIAAPVLALWAAYRGAPLAGDERDTDSVAAAEADGTDQAPAGQERPARRSYERGGSAQDRSGTQIGSGPRSAKAGRGASDVSVEVIGVDGAMASPGHKGKGGEASRPDGSPAGGGRPGGGSGPSRPAPGPGRLTVTAHPEGEVTVITLTASGGSPVHWSASAGASWLRLNHTGGVLRPGDATTITVSVDHGREPAGHWSARVSVDPAGAVVLIEGRGTSPEPTPTPTAPSGNPTPTPTDPSPTPSGPAAAKR
>NC_015957.1|WP_014053972.1|470662_472087_-|DNA-repair-protein-RadA
MAARSSSRSSAKDRPSYRCTECGWTTAKWLGRCPECQAWGTVEEYGAPAVRTTAPGRVTSAALPISQVDGRQATARGTGVDELDRVLGGGLVPGAVVLLAGEPGVGKSTLLLDVAAKAASEEHRTLYITGEESASQVRLRADRIGALSEHLYLAAETDLSAVLGHLDSVKPSLLVLDSVQTIASPEIDGAPGGMAQVREVAGALIRVSKERGMSTLLVGHVTKDGAIAGPRLLEHLVDVVLQFEGDRHARLRLVRGVKNRYGATDEVGCFELHDEGITGLADPSGLFLTRRDEPVPGTCLTVTLEGRRPLVAEVQALTVDSQIPSPRRTTSGLETSRVSMMLAVLEQRGRISALGKRDIYTATVGGVKLSEPAADLAVALALASAASDTPLPKNLVAIGEVGLAGEVRRVTGVQRRLSEAARLGFTHALVPSDPGRIPDGMRVLEVADIGDALRMLPRRRERDEKTRADAEDHG
>NC_015957.1|WP_050993876.1|469112_470171_-|DNA-integrity-scanning-protein-DisA
MRASLSAVAPGTALRDGLERVLRGNTGGLIVLGTDKTVESLCTGGFVIDVEFTATRLRELCKLDGALVLDKDITKIVRAGVQLVPDAAIATEETGTRHRTAQRVSIQTGFPVVSVSQSMRLIALYVDGQRRVLEDSAAILSRANQALATLERYKLRLDEVAGTLSALEIEDLVTVRDVSAVAQRLEMVRRIATEIAEYVVELGTDGRLLSLQLDELIAGVEPERELVVRDYVPEPTAKRTRTVADALAELDRLTHTELLELPIVARALGYTGSPETLDSAVSPRGFRLLAKVPRLPGAIIERLVEHFGGLQKLLAASVDDLQMVDGVGEARARSVREGLSRLAESSILERYV
>NC_015957.1|WP_014053970.1|467854_468718_+|hypothetical-protein
MGSLRNPIGPLPSSIYWRRRIVALALFVVIVLLVIWAFGWGGSGGGGSDEGKGSGGGGPASTITPGPSSSGPVNSERPGGRDESDNGGSGSGGSGGSGGGGGGSDDGGTDAGGGGGSGGAGGAGGSSGGGAGGGIGTGTGQGLPAGSSLPDCRPGDAELTVRSVKDSKVKNTWAPGEKPAFEIVVKNTKSKSCKVDFGRAAASLTITDAKNAHVWASGDCPEGSATALVEVKGSGQTKRTVEWDRKRSAEHCATPSGSASAKPGTYLVEVKVDGLGTAKVSFVLEKD
>NC_015957.1|WP_014053969.1|466592_467519_-|A/G-specific-adenine-glycosylase
MTAISASAVPAAASPDPDGAVLHRPVIDWFDAHARDLPWRRPEAGAWGVMVSEFMLQQTPVNRVLPVYEQWLARWPRPADLAAEPPGEAVRAWGRLGYPRRALRLHGAAAAIRERHGGDVPRDHAQLLALPGVGEYTAAAVASFAYGQRHPVLDTNVRRVFARAVGGAQYPPNATTAAERKQARTLLPGDEPTAARWAAATMELGALVCTARTPDCARCPIAALCAWRQAGSPEHDGPPRRGQTYAGTDRQVRGKLLAVLRGTVTPVPQATLDQVWHEPVQRARALDGLVSDGLVEPLSGGLYRLPLT
>NC_015957.1|WP_106685828.1|465754_466366_-|SigE-family-RNA-polymerase-sigma-factor
MMGSNVLDFEEYVRNRQDALLRSARRLIPDPVEAQDLLQTALVRTYGRWDGIADKSLADAYLRRVMINTRTEWWRARKLDEVPTEQLPEASVEDSTEQHADRALLMDILSVLAPKQRSVVVLRHWEQMTTEETAEALGMSTGTVKSTLHRALARLRQELESRDLDARALGRRDEEGKRTGNVRQHTGRVRRGRQERGQERCAA
>NC_015957.1|WP_106685609.1|465041_465767_-|hypothetical-protein
MRGLTRASPSKTAMITGGAVVGLAAAGGWMLAGCGAASEGVRKEGPARTEWAAADPGSYAGRHASGRPSPTGQKVDAIKLVKTDPNVSDDLKANLKPCPKGKVPEGKQQIEGYPVDVAYGKLTGSSASDLVINVTSCGDGFGIGSYVYRKAGDRYENVFSDEQPPVYADIDEDELRVTKLAYASGDSVCCPSSEAVITYRWTEAHNTFDVLSRKRTDYSKNVPTEEATPAPSVSADDGTEG
>NC_015957.1|WP_043235269.1|464324_465032_-|response-regulator-transcription-factor
MAETHVLFVEDDDVIREATQLALERDGFLVTAAPDGLTGLERFRADRPDIALLDVMVPGLDGVSLCRRIRDESTVPVIMLSARADSIDVVLGLEAGADDYVTKPFDGAVLVARIRAVLRRFGHASGPGGRGAEPVPEEPDGGVLCFGDLEIDPEGMEVRKGGRQVALTPTEMRLLLEFSAAPGTVLSRDRLLERVWEYGWGGDTRVVDVHVQRLRGKIGQDRIETVRGFGYKLKG
>NC_015957.1|WP_014053965.1|462962_464318_-|HAMP-domain-containing-histidine-kinase
MGRFALRTGLRWKVSLAIAAVSTLVAVVLSLVVHNAARVSMLDNSRTVMDERVKVAQRWYEQSRVLGFGAKLDDPKLPEQLKKEAWRGQRATYLEDSGTGAPEVWASVPLRNGKVLSVHTKFQDRFAVLNDLDRVLLIGSVAVVMGGIALGVLVGDQLSRRLRKAATAARKLAEGDSEVRVREAIGGRVRDETDDLARAVDGMAEALQQRLEAERRVTADIAHELRTPVTGLLTAAELLPPGRPTELVRDRAQAMRTLVEDVLEVARLDGFAERAELQEIAVAEFIARRVRAVAPDAVINVARDAHVSTDPRRLERIMGNLLANAARHGKPPFEVTVEGRVLRVRDHGPGFPEELLKDGPSRFRTGSKDRAGTGHGLGLTIAAGQARVLGARLTFRNADPVLDGPDGTDGTDGTNGTDGTDGECRGAVAVLWLPESAPTNTGSFPIIEVPD
>NC_015957.1|WP_014053964.1|462490_462958_+|glyoxalase
MIKGMSIVTVWVLDQDRAKAFYTEKLGLEVRTDMSIGGDGEGGGMRWLTVGAKDQPDVQLTLMVPSSPGLDPESAEALRTLVAKGVLGAGVFTTDDIHRDYEALKAKGVEFVQEPQERPYGTEALFRDDSGNWFSFTQPRAEMDFSQPWDGCVSD
>NC_015957.1|WP_014053974.1|474700_475573_-|hypothetical-protein
MAKTKKAKQGKSRKTAPEWAAEEPTPSGAEDASAAAAAEDEVGLDFARAWVEFPDPADDEQFFRCDLTWLTSRWTCIFGQGCQGIQAGRASDGCCTLGAHFSDEEDEERVGRHMARLSPEIWQFHDVGHASGWVQEDDDGERQTRRHKGSCIFQNRPGFAGGAGCALHILALREGREPLETKPDVCWQLPVRRSYDWIDRPDDTRVLRVTIAEYDRRGWGPGGHDLHWWCTSATSAHGAGEPVFRSYRPELTELMGKAGYNRLAELCEQRLASSLPMVAPHPADPAHPAG
>NC_015957.1|WP_014053975.1|475744_476674_+|Ppx/GppA-family-phosphatase
MRLGVLDVGSNTVHLLVMDAHPGARPLPAHSHKAELRLAELLDGAGAIGPEGVDRLIAVVKEALEAAEDKGVEDVLPFATSAVREASNADEVLARVAEATGVRLQVLSGADEARLTFLAARRWFGWSAGKLLVLDIGGGSLEIAYGMDEEPDTAVSLPLGAGRLTGSWLLGDPPDAAEVRALRRHVRAEIARTVGDFSRHGAPDHVVATSKTFKQLARITGAARSADGPYVERRLTRRALVEWVPKLAAMTTEERAELPGVSEGRAGQLPAGALVAEAALDLFGVEQLEICPWALREGVILRRLDHLST
>NC_015957.1|WP_078505073.1|477117_477963_+|sugar-phosphate-isomerase/epimerase
MTEPVVRIPDAKVALSTASVYPESTATAFEIAARLGYDGVEVMVWTDPVSQDIEALRRLSDYHQVPILAVHAPCLLITQRVWSTDPWVKLQRARAAAEKLDASTVVVHPPFRWQRSYAREFVSGIWRMADETDVRFAVENMYPWRYRDREMLAYAPDWDVTQDDYRHFTIDLSHTATARTDAMEMVDRMGDRLAHLHLADGQGSNKDEHLVPGRGTQPCAELLERLAATGFDGNVVVEVNTRRAMSTAEREADLAEALAFTRLHLASPTSATPRRRTVPGS
>NC_015957.1|WP_014053977.1|477959_478589_+|TetR/AcrR-family-transcriptional-regulator
MTPASSGPATGPRKRGRPARTSASDGPGARDRILAAARNEFAERGYDKTSIRGIAKTAEVDPALVHHYFGTKEQVFEAAIELIFAPAMAAPDAVHGSREGAGERMARFMFGIWENPVSRLPLLAVMRSALTNETASVVLRGMIERRVLLRMADELDVPNPEFRAQLAAGHLIGIAMLRYVIRMEPMASAEVDDIVTMVGPTLQRYLTES
>NC_015957.1|WP_043235274.1|478807_480658_+|dihydroxy-acid-dehydratase
MPELRSRTVTHGRNMAGARALMQASGVAREDFGKPIIAVANSFTEFVPGHTHLQPVGRIVSEAIHAAGGIPREFNTIAVDDGIAMGHGGMLYSLPSRDLIADSVEYMVEAHCADALICISNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGRATLVDGTVRKLDLINAISDAVNENVSDEDILRIENNACPTCGSCSGMFTANSMNCLTEAIGLSLPGNGSVLATHTARRALYETAGRTVVDITKRHYDHDDETVLPRSIGTRAAFDNAMALDIAMGGSTNTILHLLAAAQEAGLDYDLDDINEVSRRVPCLAKVAPNVAPGGTYYMEDVHRAGGIPAILGELFRAGMLNEDVHSVHSSSLADWLKTWDVRGGSPSAEAVELWHAAPGCKRSATAFSQSERWDTLDTDAAGGCIRDLEHAYSQDGGLAVLKGNLAVDGCVVKTAGVDESIWTFEGPAVVCESQEEAVERILGKQVKEGDVVVIRYEGPKGGPGMQEMLYPTSFLKGRGLGKACALVTDGRFSGGTSGLSIGHASPEAASGGTIALVRDGDRVRIDIPGRTIELLVSEEELAARREALGGVYTPKNRERKVSTALRAYAAMATSADKGAVRDISRLG
>NC_015957.1|WP_078505076.1|480641_481103_-|PQQ-binding-like-beta-propeller-repeat-protein
MLSPYPPLPAASGCGSAAWGLRPWAPLLKCRREGLSAQQTQPTLVGDTLYFVRQNGEVTAVTTAGKRLWSEATEVEWLGAPVVSGRRNALYPATAAGRTVALDRGDGRVLWRGKARTDPGGVPAELTLSGDALTTVYGYDTVEAAGTDVSRGG
>NC_015957.1|WP_043235279.1|481140_483471_-|PQQ-binding-like-beta-propeller-repeat-protein
MPPVHRAGTGPEAEDPEYAGQYRLEARLGSGGMGVVHLARSPSGRHLAVKVVHAAYAEDPEFRARFRQEVAAARRVSGAFTAPVVDADPEGPRPWMATLYIPGPTIAEHVKRSGPLPPDETVQLAAGLAEALRDIHRVGVVHRDLKPSNVLLAADGPKVIDFGISRPSDSELRTETGQLIGTPPFMAPEQFQRPRAVGPAADVFALGSLLVHAATGRGPFESESPYIVAYQVVHDEADLAGVPDELLPLIQRCLAKNPEERPTPDALMTVLRAVRGPHPPMPRGPVRLVPQQRTPEPHSLPGGRAEQVGGATDTHVKAASEPAPRLMKDMKAEPERGADEAESVTSGPVTDGPVADESMADGPGARRRGIRRWALSGLAALVLLGAGTVVALRPFGDADASGGRQPRNSAATTEAWRPWTTGLDVGKAAGSGARPAFCSYGAGALYCTRRGIEAARVDPDDGRVVWSRPSAAGSPGDGEAVSAPVFSGGLVQTVSQDGGRLRALDPTTHDVRWSREVSRYDGGVYASGDTVLLAAPDGTVTAVNGATNKERWSHRLPGHARPAFFSYGDGRTAYAVTAAGDGAHTVVTAVDTVRGDTRWHASLSGNLTPAGSGPGGVLLLTETDTRTRTTAVVRYDPERRTARRVALSAPVSATSVVTSGDRVYVLGSDGGLVAVDTGREGAARARLWRLETSVANASPLVAADGRLYFSAADGRLLAVDAERGEVIGETRRSRGGAAGRGFLDLMPAPVVADGKVFATGPDGTVFAVDGRDPAGW
>NC_015957.1|WP_014053980.1|483617_483953_+|SH3-domain-containing-protein
MAIEETAETVATTDTASATDAADVMATAGAITYPTAPGYQVNVRSGPGTNHRVVKVLPYNTRVPIRCQRHGEQVSGPYGTTDIWDSIAPGQYVSDAYVRTGSDGFVTVPCG
>NC_015957.1|WP_014053981.1|484043_485600_-|SulP-family-inorganic-anion-transporter
MRNSLLDRFRGAGGTSGSSGAKTFRADFTASLVVFLVAVPLCVGVAVASGVPAELGLITGIVGGLVTGFLPGSSLQVSGPAAGLTVLVYEAVEQYGVAALGVLVLISGLLQLAMGAFGLGRWFRAISVAVVQGMLAGIGLVLIAGQLYALADAKAPTSGLDKIFGIPELIGDVAGSGDALKALAVGVGTIAVLVLWPRFRQGAKVLPAPLAAVALATASTVIFDLPIARVEVKGLLDAIQPPGGSEFQALAEVGVIGTVLAFTLIASAESLFSAAAVDRLHDGARTDYDKELMAQGAGNAVCGVLGALPMTAVIVRSAANVQAGAKTKASRVLHGVWLLIFAVLFPSALGIIPVATLAGVLVYSGWKLIPTKDLVPLWRAHRGEAIILVVTAGAIVITNMFEGVVIGLLMAVAKTAWETSHVHVEVSGREDGAGAGDGAGAGADDKPLHVRVRGHATFLRLPKLLDELEGLPREREVELDLTGLRHVDHACEMALATWAERHNAVVKRDAALEEQVPA
>NC_015957.1|WP_106685610.1|485777_486200_-|hypothetical-protein
MGVGVYTYGRGAMVRSIRHTAHALVTAVAVLLALFIAADCASAQVIHPETSSVTASADPRPATESSVAAHGDNGTEDCKGLRGRAPLTAPTPSGKYGCVCGCDTGVPVPRTAISTSITERQAVPVSRSGELPVILQIFRC

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Crispr_ID: NC_015957_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015957_4

569158-569286

Orphan

Consensus_repeat	Method
AGCCGTAAGGCGGCCACGAACGCGGC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_015957_4

>merge|NC_015957|4|569158-569286|CRISPRCasFinder
AGCCGTAAGGCGGCCACGAACGCGGCCCTACGAGCCGTAACGTGGCCCTACGAGCCGTAAGGCGGCCGTACGAGCCGTAAGGCGGCCACGCACGCGGCATACGAGCCGTAAGGCGGTCACCGGCCGGGC

>NC_015957|4|4|569158-569286|CRISPRCasFinder
AGCCGTAAGGCGGCCACGAACGCGGC	CCTACGAGCCGTAACGTGGCCCTACG
AGCCGTAAGGCGGCCGTACGAGCCGT	AAGGCGGCCACGCACGCGGCATACG
AGCCGTAAGGCGGTCACCGGCCGGGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015957.1\|WP_014054061.1\|572457_573273_-\|C40-family-peptidase	unknown	unknown	gnl\|CDD\|366353
NC_015957.1\|WP_043237723.1\|569443_570715_+\|geranylgeranyl-reductase-family-protein	unknown	unknown	gnl\|CDD\|273936
NC_015957.1\|WP_014054047.1\|558338_559355_-\|esterase-family-protein	unknown	unknown	gnl\|CDD\|223700
NC_015957.1\|WP_014054050.1\|561574_562666_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|378890
NC_015957.1\|WP_014054052.1\|563350_563554_-\|cold-shock-protein	unknown	unknown	gnl\|CDD\|224197
NC_015957.1\|WP_014054063.1\|574379_574934_+\|NADH-quinone-oxidoreductase-subunit-B	unknown	unknown	gnl\|CDD\|235797
NC_015957.1\|WP_050993878.1\|577120_577930_+\|NADH-quinone-oxidoreductase-subunit-NuoE	unknown	unknown	gnl\|CDD\|181024
NC_015957.1\|WP_014054065.1\|575768_577103_+\|NADH-quinone-oxidoreductase-subunit-D	unknown	unknown	gnl\|CDD\|180385
NC_015957.1\|WP_014054049.1\|560311_561475_-\|secretory-lipase	unknown	unknown	gnl\|CDD\|367570
NC_015957.1\|WP_014054055.1\|566769_567969_+\|dehypoxanthine-futalosine-cyclase	unknown	unknown	gnl\|CDD\|274731
NC_015957.1\|WP_078505081.1\|559486_560191_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_015957.1\|WP_014054064.1\|575025_575769_+\|NADH-quinone-oxidoreductase-subunit-C	unknown	unknown	gnl\|CDD\|181115
NC_015957.1\|WP_043237721.1\|563910_564768_+\|menaquinone-biosynthesis-protein	unknown	unknown	gnl\|CDD\|270352
NC_015957.1\|WP_043235315.1\|562809_563256_+\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|377622
NC_015957.1\|WP_014054056.1\|567968_568418_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235963
NC_015957.1\|WP_014054067.1\|577929_579312_+\|NADH-quinone-oxidoreductase-subunit-NuoF	unknown	unknown	gnl\|CDD\|131014
NC_015957.1\|WP_014054054.1\|564878_566663_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_015957.1\|WP_014054062.1\|573987_574347_+\|NADH-quinone-oxidoreductase-subunit-A	unknown	unknown	gnl\|CDD\|181171
NC_015957.1\|WP_014054060.1\|571908_572328_+\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|341390
NC_015957.1\|WP_014054059.1\|570871_571654_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319911

Protein	Function_ID	Function_description	E-value
NC_015957.1\|WP_014054061.1\|572457_573273_-\|C40-family-peptidase	gnl\|CDD\|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	4.43605e-30
NC_015957.1\|WP_043237723.1\|569443_570715_+\|geranylgeranyl-reductase-family-protein	gnl\|CDD\|273936	TIGR02032, Uncharacterized_protein_MJ1520, geranylgeranyl reductase family. This model represents a subfamily which includes geranylgeranyl reductases involved in chlorophyll and bacteriochlorophyll biosynthesis as well as other related enzymes which may also act on geranylgeranyl groups or related substrates. [Biosynthesis of cofactors, prosthetic groups, and carriers, Chlorophyll and bacteriochlorphyll].	8.17903e-100
NC_015957.1\|WP_014054047.1\|558338_559355_-\|esterase-family-protein	gnl\|CDD\|223700	COG0627, COG0627, Predicted esterase [General function prediction only].	6.69054e-43
NC_015957.1\|WP_014054050.1\|561574_562666_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|378890	pfam12625, Arabinose_bd, Arabinose-binding domain of AraC transcription regulator, N-term. AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].	5.15708e-42
NC_015957.1\|WP_014054052.1\|563350_563554_-\|cold-shock-protein	gnl\|CDD\|224197	COG1278, CspC, Cold shock proteins [Transcription].	2.42264e-35
NC_015957.1\|WP_014054063.1\|574379_574934_+\|NADH-quinone-oxidoreductase-subunit-B	gnl\|CDD\|235797	PRK06411, PRK06411, NADH-quinone oxidoreductase subunit NuoB.	3.4693e-102
NC_015957.1\|WP_050993878.1\|577120_577930_+\|NADH-quinone-oxidoreductase-subunit-NuoE	gnl\|CDD\|181024	PRK07539, PRK07539, NADH-quinone oxidoreductase subunit NuoE.	1.31463e-84
NC_015957.1\|WP_014054065.1\|575768_577103_+\|NADH-quinone-oxidoreductase-subunit-D	gnl\|CDD\|180385	PRK06075, PRK06075, NADH-quinone oxidoreductase subunit D.	0
NC_015957.1\|WP_014054049.1\|560311_561475_-\|secretory-lipase	gnl\|CDD\|367570	pfam03583, LIP, Secretory lipase. These lipases are expressed and secreted during the infection cycle of these pathogens. In particular, C. albicans has a large number of different lipases, possibly reflecting broad lipolytic activity, which may contribute to the persistence and virulence of C. albicans in human tissue.	5.29747e-52
NC_015957.1\|WP_014054055.1\|566769_567969_+\|dehypoxanthine-futalosine-cyclase	gnl\|CDD\|274731	TIGR03699, menaquin_MqnC, dehypoxanthine futalosine cyclase. members of this protein family are involved in menaquinone biosynthesis by an alternate pathway via futalosine. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone].	0
NC_015957.1\|WP_078505081.1\|559486_560191_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.31773e-13
NC_015957.1\|WP_014054064.1\|575025_575769_+\|NADH-quinone-oxidoreductase-subunit-C	gnl\|CDD\|181115	PRK07785, PRK07785, NADH dehydrogenase subunit C; Provisional.	1.86328e-158
NC_015957.1\|WP_043237721.1\|563910_564768_+\|menaquinone-biosynthesis-protein	gnl\|CDD\|270352	cd13634, PBP2_Sco4506, The conserved hypothetical protein SCO4506 exhibits the type 2 periplasmic-binidng protein fold. This group includes the SCO4506 protein from Streptomyces coelicolor and related hypothetical proteins. SCO4506 is an ortholog of Ttha1568 (MqnD) from Thermus thermophilies HB8. MqnD is an enzyme within an alternative menaquinone biosynthetic pathway that catalyzes the conversion of cyclic de-hypoxanthine futalosine to 1,4-dihydroxy-6-naphthoate. Menaquinone (MK; vitamin K) is an essential lipid-soluble carrier that shuttles electrons between membrane-bound protein complexes in the electron transport chain. SCO4506 has significant structural homology with the members of type 2 periplasmic-binding fold protein superfamily. The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.05958e-113
NC_015957.1\|WP_043235315.1\|562809_563256_+\|cupin-domain-containing-protein	gnl\|CDD\|377622	pfam06172, Cupin_5, Cupin superfamily (DUF985). Family of uncharacterized proteins found in bacteria and eukaryotes that belongs to the Cupin superfamily.	3.2718e-67
NC_015957.1\|WP_014054056.1\|567968_568418_+\|hypothetical-protein	gnl\|CDD\|235963	PRK07203, PRK07203, putative aminohydrolase SsnA.	0.000979722
NC_015957.1\|WP_014054067.1\|577929_579312_+\|NADH-quinone-oxidoreductase-subunit-NuoF	gnl\|CDD\|131014	TIGR01959, NADH-quinone_oxidoreductase_subunit_F, NADH-quinone oxidoreductase, F subunit. This model describes the F chain of complexes that resemble NADH-quinone oxidoreductases. The electron acceptor is a quinone, ubiquinone, in mitochondria and most bacteria, including Escherichia coli, where the recommended gene symbol is nuoF. This family does not have any members in chloroplast or cyanobacteria, where the quinone may be plastoquinone and NADH may be replaced by NADPH, nor in Methanosarcina, where NADH is replaced by F420H2. [Energy metabolism, Electron transport].	0
NC_015957.1\|WP_014054054.1\|564878_566663_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.04447e-87
NC_015957.1\|WP_014054062.1\|573987_574347_+\|NADH-quinone-oxidoreductase-subunit-A	gnl\|CDD\|181171	PRK07928, PRK07928, NADH dehydrogenase subunit A; Validated.	4.38677e-77
NC_015957.1\|WP_014054060.1\|571908_572328_+\|CBS-domain-containing-protein	gnl\|CDD\|341390	cd04622, CBS_pair_HRP1_like, CBS pair domain found in Hypoxic Response Protein 1 (HRP1) -like proteinds. Mycobacterium tuberculosis adapts to cellular stresses by upregulation of the dormancy survival regulon. Hypoxic response protein 1 (HRP1) is encoded by one of the most strongly upregulated genes in the dormancy survival regulon. HRP1 is a 'CBS-domain-only protein; however unlike other CBS containing proteins it does not appear to bind AMP. The biological function of the protein remains unclear, but is thought to contribute to the modulation of the host immune response. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).	4.88346e-49
NC_015957.1\|WP_014054059.1\|570871_571654_-\|VOC-family-protein	gnl\|CDD\|319911	cd07247, SgaA_N_like, N-terminal domain of Streptomyces griseus SgaA and similar domains. SgaA suppresses the growth disturbances caused by high osmolarity and a high concentration of A-factor, a microbial hormone, during the early growth phase in Streptomyces griseus. A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) controls morphological differentiation and secondary metabolism in Streptomyces griseus. It is a chemical signaling molecule that at a very low concentration acts as a switch for yellow pigment production, aerial mycelium formation, streptomycin production, and streptomycin resistance. The structure and amino acid sequence of SgaA are closely related to a group of antibiotics resistance proteins, including bleomycin resistance protein, mitomycin resistance protein, and fosfomycin resistance proteins. SgaA might also function as a streptomycin resistance protein.	5.07001e-31

>NC_015957.1|WP_014054056.1|567968_568418_+|hypothetical-protein
MLTLHAAPVVRYTPDDAAPLHEAAVAVDGDRIAAIGPLEELRRAFPRARVREWPGELGPALVHEGPVPDAPSPRERIHALLRRGATAVLAQHLGDAELRAAAHRGGITVLDRPRPPVLALAGRADLAVFDADGACLATVVAGRLVHRRR
>NC_015957.1|WP_014054055.1|566769_567969_+|dehypoxanthine-futalosine-cyclase
MTANAEVQVVLDRAADGGRITPQEALDLYRSAPLHALGAAADAVRRRRYAGTEHIATYIIERNINYTNVCVTACKFCAFYAAPKDTAKGWSRDLDDILRRCAETVELGGTQIMFQGGHHPDYGVEYYEKHFSAIKKAFPQLVIHSLGASEVEHMARISGVPAEEAIRRIHAAGLDSFAGAGAELLPERPRKAIAPLKESGERWLEIMEIAHNLGVESTSTMLMGTGETNAERIEHIRMIRDVQDRTGGFRAFIPYTYQPENNHLKGQTQATVFEYLRMIAIARLFLDNVAHIQGSWLTVGKEAGQLALHYGADDLGSVMLEENVVSSAGARHRSNRMELLHLIRAAGRVPAQRATTYEHLVVHDDPANDPVDDHVVSHLSSTAIDGGTAHPELTVIQAS
>NC_015957.1|WP_014054054.1|564878_566663_+|serine/threonine-protein-kinase
MDPLGADDPQVIGAYRLLGRLGSGGMGRVFVGRSVGGRTVAVKVVHAHFALDEEFRARFRREVDAARRVGGAFTAPVLDADPEARIPWVATGYVAGPPLNQAVSDEGPLPESAVRALGAGLAEALAAVHALGLVHRDVKPSNVLLALDGPRLIDFGIARATEGTVSLTSTGASIGSPGYMAPEQILGEGVEGAADVFSLGAVLAYAATGKPPFPGDTSAALLYKVVHDEPRLGPELTGDLRDLVAACLAKNPADRPTPERIVRRLAPEDGASGLARPGWLPGALVERVSRQVVELLDLEAEAVAPPRVAEPPAIGPSSIGLSSTGPSSAEPSATEPPAAEPSTTQPPAADSPTPPPTPAPASPLLGAFGPPDPSYANGLPPKDQPTGPPLPYPPSSKPGGRSVALSAAVGGKKRPKALSCTLVLSVAGALAVATTAAVLFKVLPGGSGDNSDQGAADPRPSATGRNPGDGAHDGSGKGAVPKAFLGTWQGDLTSDSGIPVGTLTITFRQGRTGQDVASGRVKLSVLRCDSTWKLVSAAPKQLHLDARLKGSEPQQGCSDASTDEQFTLTSDGALSYQAKDDQAGDPTGTLRKLE
>NC_015957.1|WP_043237721.1|563910_564768_+|menaquinone-biosynthesis-protein
MRPSVGHRLSRPKVGHIQYLNCMPLYWGLARTGSLLDFELTKASPDALNDLLVRGDLDIGPISLVEYLRNADDLVALPDIAVGCDGPVMSCVIVSQLPLEQLNGARIALGSASRTSVRLAQLLLAERYGLTPDYYTCPPDLSLMMQEADAAVLIGDAALRANLHDAPRLGLQVHDLGQMWKEWTGLPFVFAVWAARREYLEREPEIVRGVHQAFLESRNVSLEEVGKVAEQAARWEQLESSVLERYFTTLDFSLGAEQLQGIAEFARRTGPTTGYPADVRVDLLT
>NC_015957.1|WP_014054052.1|563350_563554_-|cold-shock-protein
MATGTVKWFNAEKGFGFIAQDGGGPDVFVHYSAINATGFRSLEENQAVTFDVTQGPKGPQAENVSPV
>NC_015957.1|WP_043235315.1|562809_563256_+|cupin-domain-containing-protein
MTTSRRPATAEWLGLEPHPEGGWYRETWRSDVTVRLPGYQGERATATAIYFLLTPGEESRWHVVRSAELWLWHSGGPLQLRLGGTGDGPEATPTELVLGSDIASGQRPQAVVPPGTWQSARPAADEEVLVSCVVSPGFDFADFRLLED
>NC_015957.1|WP_014054050.1|561574_562666_-|AraC-family-transcriptional-regulator
MGRGRRTVTVHHVRAALRGAQRLGLDTVPLLQRARIPPLLLTDDRARVSPEQFARLVRALHRATGDEFLGLGTIRSRPGTFAMMCYASLGCPDLGTAVERGARFYRLFPGGPNLALERGEGHGREAVLALRGGLGPHADGLTAAEHHIVAEWLMLIWHRLAGWLIGRRVPLLWAQFAYPPPPYADDYEPLFGCPPRFGAPRTAAGFDRRWLTAPVVQDESTLQTLLRHAPAGLLSRRAYGTTVAEQVRHALTGALRARGGPATSPRGRRTTRLPELPEVAARLAVSPATLRRRLREEGTSFQELKDTVRRDEAVSSLAEGVEPIADLSARLGFSEDTAFHRAFRRWTGSTPGAYRHETWSQQI
>NC_015957.1|WP_014054049.1|560311_561475_-|secretory-lipase
MRIRTTVLATLAALALASAPPAAAAISGAPAAGTGRPGDILTSAPTAFRTQPGVPTATRAWHITYRSTTATGRPDVVSGTVVVPDDGKQGPRPLLTWGIGAVGLSDDCAVSGRFPQGTSIEAQLIDLALRRGWAVAVTDYEGLGTPGDHTYTAGRSEGHAVLDAARAAQRLPEAGLSPDTPVGIMGYSQGGQAAGWAAELHASYAPELRLKGTVAGGVPADLPTTLDYNDGGAGAGLALMALTGQDAAFPALRLDAYLNDRGRGYVDFIKRNCVALSTIAGLFQRMSEVTVRDPLTSPAWQLALRSSYLGTRSPDRPVYLYQGLLDELIPYRVGEALRTRWCARGAPVEWQDYPLDHVTTALTGLPAALDWMAGRLADEPTRGNCTA
>NC_015957.1|WP_078505081.1|559486_560191_+|TetR/AcrR-family-transcriptional-regulator
MCAGARSKGAACVGGATGSKRVPRAVREQQMLDAGVRAFARSGYQNASMDDIAELAGVSKPLVYLYLNSKEELFTACIRREAVALVTAVRAAVERDAPADRQLWSGLSGFFAHAAEHPDGWTLLHVQARTHGQPYAREVAAMRAEIVEFVTQLIGAAAREHARGAARARTLAGTEVSGLAHALVGAAESLADWAGDGRVGGHSAKEAAATLMNFAWAGLGNLLQGTGWSPERVG
>NC_015957.1|WP_014054047.1|558338_559355_-|esterase-family-protein
MPNRRRAVAALTALAAAPLLTSTAEARSREPGPSKARPAEALAGRRTPARARLIAADRVSERVLDLTIDSPALGREGHARVLLPTGYDRRPHHRWPVLYLLHGCCDPGPGWEAWTLNTDVEAITAGTPALIVSPEGGPVGFYSDWWNGGHYGAPAWETFHLAELRPLLERALRANGRRTIAGLSMGGFGALSYAARHPRLFRAAASFSGVVHTTLDPAGIQGILTGQGADPTALWGDPAAQSALWGAHNPYALIPRLPRGYPLYVACGNGTPGPLDPPDRPEDTLERGLGEMAQRYVRRARTHGLAVTAHLYGPGTHTWPYWERELTRALPLLTAPLL
>NC_015957.1|WP_043237723.1|569443_570715_+|geranylgeranyl-reductase-family-protein
MSERSADVIVVGAGPAGSTTAYHLAKAGLDVVLLEKTAFPREKVCGDGLTPRATKQLVAMGIDISEEAGWLRNRGLRIIAGGVRLQLDWPDLAAYPNYGLVRKRDDFDEQLARQAQKAGARLYERCNVGAPITDERTGRITGVHAKLGEEKTPVAFHAPLVVAADGNSTRLSLAMGLHRREDRPMGVAVRTYFTSPRHDDDYLESWLELWDRRGAQDRLLPGYGWIFGMGDGTSNVGLGVLNTSSSFKELDWREVLKAWCASMPEDWGYTPENMTGPIRGAALPMAFNRQPHYTRGLLLVGDAGGMVNPFNGEGIAYAMESGQIAADVIVQAHARATAPQRELALQRYPKVLKDTYGGYYTLGRAFVKLIGNPKVMKLAAQRGLTHPMLMRFTLKLLANLTDPTGGDAMDRIINGLTKVTPRA
>NC_015957.1|WP_014054059.1|570871_571654_-|VOC-family-protein
MLTTDYVPGAPNWLDLGAPDTEAAVAFYGSLMGWRFESAGPEAGGYGFFTLGRKTVAAVGPLTEEGARSAWTPYFHTRDAEETARTVEQSGGTVRLAPFDVFEEGRMAQFTDPGGARFAIWQPGRTAGLDAVNDPGALCWTELHSPDPPRDLAFYRKVFGWDAEEMSFPGGAYTVLMTTGAGREGSFGGVAQLQEGHSTPPQWLPYFEVADCDAVVAKGQDLGGSVLMPAMSAEGIGRMAWLADVVRAPFGVIASGGPGA
>NC_015957.1|WP_014054060.1|571908_572328_+|CBS-domain-containing-protein
MTKAADIMHPGAQWIPENESVLRAAQMMRDLGVGALPVSDSNERLCGIVTDRDIVVGCIAENCDPSRTPVGQLTEGTPRWIPADADVTDVLREMEEHKIRRLPVIDQNKRLVGMISEADLAHHLSDDLLGEFLEKVYAQ
>NC_015957.1|WP_014054061.1|572457_573273_-|C40-family-peptidase
MSPVAHIPSHRKPRRAASTRALRAGMTGGFLTLAVAGAAVPASATESKAAPAESTLEMPTVSATLASTAAQTADATQQAASDYELRAQQEQAEAHAKIAAKKAKAEADRKAKEAREAARKAAAKRAAEAKAQAAKASRSAERTTLSTTSVSNATGNTATLISFLKAQLGKAYVLGSSGPSSYDCSGLTQAAFKQIGVSLPRVSQDQSTTGTSVSLDSLQPGDLLYWGSAGSAYHVGVYVGGGNFIGAQNSSTGIVERPLDYDMPTGAVRVL
>NC_015957.1|WP_014054062.1|573987_574347_+|NADH-quinone-oxidoreductase-subunit-A
MNAYAPILVLGALGAGFAIFSVLMAAIIGPKRYNRAKLEAYECGIEPTPHPSGGGRFPIKYYLTAMLFIVFDIEIVFLYPWAVTFDALGLFGLVEMLLFVLTVFVAYAYVWRRGGLEWD
>NC_015957.1|WP_014054063.1|574379_574934_+|NADH-quinone-oxidoreductase-subunit-B
MGIEEKLPSGFLLTTVEQAAGLARKSSVFPATFGLACCAIEMMTTGAGRYDLARFGMEVFRGSPRQADLMIVAGRVSQKMAPVLRQVYDQMPNPKWVISMGVCASSGGMFNNYAIVQGVDHIVPVDIYLPGCPPRPEMLLDSILKLHQKIREEKLGVNRERAAREAEEAALKALPLIEMKGLLR
>NC_015957.1|WP_014054064.1|575025_575769_+|NADH-quinone-oxidoreductase-subunit-C
MTEANGSNGVNPDKDLNAENLPGRRGDQGEPVRVQRGMFGANNGGDTTGYGGLVRPVRLPGQATRPYGGWFDEVADELEGALEEQSLLPENAIEKTVVDRDELTFHIAREHLPRVARTLRDDPALRFELCTGVSGVHFPGDKGRELHAVYHLRSLTHGRVVRLEVCAPDSDPHIPSIVDVYPTNDWHERETYDFFGLIFDGHPALTRIMMPDDWQGFPQRKDYPLGGIPVEYKGAQIPAPDQRRSYS
>NC_015957.1|WP_014054065.1|575768_577103_+|NADH-quinone-oxidoreductase-subunit-D
MTAPHATPSASARETTEGTVYTVTGGDWDEVVAAAAKADDERIIVNMGPQHPSTHGVLRLILEIDGETVTEARCGIGYLHTGIEKNLEFRNWTQGTTFVTRMDYLTPFYNEAAYCLGVEKLLGIEDQIPDRATVIRVLLMELNRLSSHLVAIATGGMELGATTIMIYGFRDRELILDVFELVTGLRMNHAFIRPGGLAQDLPPGAVDQIRALLKTMRKNLPEYDKLATGNPVFKARLQNVGYLDLAGCMALGVTGPILRATGLPHDLRKTDPYCGYETYDFEVPTADTCDAYGRFLIRLEEMRQSLRIVEQCLERLEPGPVMVADKKIAWPAQLALGPDGLGNSLDHIKNIMGTSMEALIHHFKLVTEGFRVPPGQTYAAIESPKGELGAHMVSDGGTRPFRVHFRDPSFTNLQSVAAMCEGGQVADVIVAVASIDPVMGGVDR
>NC_015957.1|WP_050993878.1|577120_577930_+|NADH-quinone-oxidoreductase-subunit-NuoE
MPELPAPDYPAEVRARLEADAREVIARYPDSRSALLPLLHLVQSEEGHVTRTGMRFCAEVLGLTTAEVTAVATFYTMYRRKPSGDYQVGVCTNTLCAVMGGDAIFEELQSHLGVGNGETTEDGKVTLEHIECNAACDYAPVVMVNWEFFDNQTIESAKGLVDDLRAGRTVEPTRGAPLCTYQETARILAGFPDARPGAVEAGGSAGPASLVGLRLAKGETAPGRVVSPRSADAPQDEAPPTHPSSHDAPQRTSASDPHHPAGPVAEEGE
>NC_015957.1|WP_014054067.1|577929_579312_+|NADH-quinone-oxidoreductase-subunit-NuoF
MTVTTEVNGHSPEKLLAPVLSAFWDQPNSWALRTYLRHEGYEGMRKALAMDPDAVIALVKDAGLRGRGGAGFPTGMKWQFIPQGDGKPHYLVVNADESEPGTCKDIPLLYANPHSLIEGMVIACHAIRSEHAFIYLRGETVPVLRRLHEAVREAYEAGYLGTAERRRDKLGVDGLPGLDITVHAGAGAYICGEETALLDSLEGRRGQPRLRPPFPAVAGLYACPTVVNNVESIASVPAILNKGKEWFRSMGSEKSPGFTLYSLSGHVANPGQFEGPLGITLRQLLDMSGGMRPGHRLKFWTPGGSSTPLLTEEHLDVPLDYEGVGAAGSMLGTKALQCFDETTCVVRAVTRWTEFYAHESCGKCTPCREGTYWLVQLLRDLEAGKGRMDDLDKLADIADNINGKSFCALGDGAASPIFSSLKYFREEYEQHITGGGCPFDPAKSTVWADEPRSTHLGVNA

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Crispr_ID: NC_015957_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015957_5

760176-760439

Orphan

Consensus_repeat	Method
TCGTGCGGGTGTGACGTCTCGGGCCGTGCGGTGCTGGCGTGATGCCTCGGG	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_015957_5

>merge|NC_015957|5|760176-760439|CRISPRCasFinder
CCGTGTGGGTGTGAGGGTTCGGGCCGCGCCGCGTGGGTGCGAGGCTTCCGGGCCGCGCCGTGCAGGTGACCCTCCGCGGGCCGGACACTGTGTGGCTGACGCCCCGGGATCGCATCGTGCGGGTGTGACGTCTCGGGCCGTGCGGTGCTGGCGTGATGCCTCGGGGCACAGCCTCGGGATCGCACCGTACGGGTGTGATGCCCCGGGGCCACCTCGTGCGGGTGTGACGTCTCGGGCCGTGCGGTGCTGGCGTGATGCCTCGGG

>NC_015957|5|5|760176-760439|CRISPRCasFinder
CCGTGTGGGTGTGAGGGTTCGGGCCGCGCCGCGTGGGTGCGAGGCTTCCGG	GCCGCGCCGTGCAGGTGACCCTCCGCGGGCCGGACACTGTGTGGCTGACGCCCCGGGATCGCA
TCGTGCGGGTGTGACGTCTCGGGCCGTGCGGTGCTGGCGTGATGCCTCGGG	GCACAGCCTCGGGATCGCACCGTACGGGTGTGATGCCCCGGGGCCACC
TCGTGCGGGTGTGACGTCTCGGGCCGTGCGGTGCTGGCGTGATGCCTCGGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_015957.1\|WP_003948568.1\|753054_753666_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NC_015957.1\|WP_014054236.1\|756312_757440_+\|GuaB3-family-IMP-dehydrogenase-related-protein	unknown	unknown	gnl\|CDD\|236322
NC_015957.1\|WP_014054244.1\|767946_769950_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_015957.1\|WP_014054235.1\|754725_756228_+\|IMP-dehydrogenase	unknown	unknown	gnl\|CDD\|235507
NC_015957.1\|WP_014054243.1\|766552_767785_-\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NC_015957.1\|WP_014054245.1\|770108_772937_+\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_015957.1\|WP_014054233.1\|752331_752646_-\|WhiB-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376791
NC_015957.1\|WP_043235356.1\|751358_752261_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176115
NC_015957.1\|WP_106685612.1\|760583_763061_+\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014054231.1\|750608_751277_-\|MOSC-domain-containing-protein	unknown	unknown	gnl\|CDD\|225167
NC_015957.1\|WP_014054239.1\|759002_760160_+\|rod-shape-determining-protein	unknown	unknown	gnl\|CDD\|237562
NC_015957.1\|WP_014054248.1\|775976_776981_+\|acyl-CoA/acyl-ACP-dehydrogenase	unknown	unknown	gnl\|CDD\|224871
NC_015957.1\|WP_014054242.1\|764811_766518_+\|glycerol-3-phosphate-dehydrogenase/oxidase	unknown	unknown	gnl\|CDD\|223651
NC_015957.1\|WP_014054246.1\|772933_774568_-\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|171961
NC_015957.1\|WP_014054249.1\|777446_778019_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|340413
NC_015957.1\|WP_014054234.1\|753956_754568_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|236607
NC_015957.1\|WP_014054238.1\|758469_758913_-\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014054237.1\|757545_758259_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236669
NC_015957.1\|WP_014054247.1\|774804_775968_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173841
NC_015957.1\|WP_014054241.1\|763330_764605_-\|nucleotide-sugar-dehydrogenase	unknown	unknown	gnl\|CDD\|223749

Protein	Function_ID	Function_description	E-value
NC_015957.1\|WP_003948568.1\|753054_753666_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.73082e-50
NC_015957.1\|WP_014054236.1\|756312_757440_+\|GuaB3-family-IMP-dehydrogenase-related-protein	gnl\|CDD\|236322	PRK08649, PRK08649, GuaB3 family IMP dehydrogenase-related protein.	0
NC_015957.1\|WP_014054244.1\|767946_769950_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.54143e-102
NC_015957.1\|WP_014054235.1\|754725_756228_+\|IMP-dehydrogenase	gnl\|CDD\|235507	PRK05567, PRK05567, inosine 5'-monophosphate dehydrogenase; Reviewed.	0
NC_015957.1\|WP_014054243.1\|766552_767785_-\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	1.29637e-46
NC_015957.1\|WP_014054245.1\|770108_772937_+\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.25419e-17
NC_015957.1\|WP_014054233.1\|752331_752646_-\|WhiB-family-transcriptional-regulator	gnl\|CDD\|376791	pfam02467, Whib, Transcription factor WhiB. WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.	1.62603e-26
NC_015957.1\|WP_043235356.1\|751358_752261_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176115	cd08423, PBP2_LTTR_like_6, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold. LysR-transcriptional regulators comprise the largest family of prokaryotic transcription factor. Homologs of some of LTTRs with similar domain organizations are also found in the archaea and eukaryotic organisms. The LTTRs are composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The genes controlled by the LTTRs have diverse functional roles including amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to a name a few. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.24933e-57
NC_015957.1\|WP_014054231.1\|750608_751277_-\|MOSC-domain-containing-protein	gnl\|CDD\|225167	COG2258, COG2258, Uncharacterized protein conserved in bacteria [Function unknown].	1.20759e-63
NC_015957.1\|WP_014054239.1\|759002_760160_+\|rod-shape-determining-protein	gnl\|CDD\|237562	PRK13927, PRK13927, rod shape-determining protein MreB; Provisional.	0
NC_015957.1\|WP_014054248.1\|775976_776981_+\|acyl-CoA/acyl-ACP-dehydrogenase	gnl\|CDD\|224871	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism].	3.95427e-28
NC_015957.1\|WP_014054242.1\|764811_766518_+\|glycerol-3-phosphate-dehydrogenase/oxidase	gnl\|CDD\|223651	COG0578, GlpA, Glycerol-3-phosphate dehydrogenase [Energy production and conversion].	3.07091e-163
NC_015957.1\|WP_014054249.1\|777446_778019_+\|ATP-binding-protein	gnl\|CDD\|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	2.60643e-13
NC_015957.1\|WP_014054234.1\|753956_754568_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|236607	PRK09648, PRK09648, RNA polymerase sigma factor ShbA.	1.13413e-88
NC_015957.1\|WP_014054246.1\|772933_774568_-\|AMP-binding-protein	gnl\|CDD\|171961	PRK13295, PRK13295, cyclohexanecarboxylate-CoA ligase; Reviewed.	7.62503e-120
NC_015957.1\|WP_014054237.1\|757545_758259_-\|hypothetical-protein	gnl\|CDD\|236669	PRK10263, PRK10263, DNA translocase FtsK; Provisional.	1.41022e-07
NC_015957.1\|WP_014054247.1\|774804_775968_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|173841	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26. Putative acyl-CoA dehydrogenases (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	3.33389e-161
NC_015957.1\|WP_014054241.1\|763330_764605_-\|nucleotide-sugar-dehydrogenase	gnl\|CDD\|223749	COG0677, WecC, UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane].	4.04903e-135

>NC_015957.1|WP_014054239.1|759002_760160_+|rod-shape-determining-protein
MAQNKSFNGRDMGIDLGTANTLVYVRGRGIVLNEPSVVAVNTADGSVLSVGTAAKETMGRTPANIVAVRPLRDGVIADFEIAERMLRYFIKKVMGSRRLARPRVVVCVPSGITGVERRAVMEAATQAGARQVHLVEEPIAAAIGAGLPVSEPTGCMVVDIGGGTTEVAVVSLGGIVTARSVRTAGDSMDVAITSYVKKQYALAIGERTAEEIKVSIGSASPAGSLSVPRVSEAVRRPERNVEVFIPGQSEDPEDTQALLPPDRCTIRGRDQATGLPKVLELTADEVRHALSEPVDSIVAAVRSTLDETPPELAGDIMDRGIVLTGGGALLRGLDVRLGRELNIPVLVADDPLDCVAIGTGRCVEDFASLRTAMDARPRRPDTVRV
>NC_015957.1|WP_014054238.1|758469_758913_-|hypothetical-protein
MIASAPSAAQAPRPARGLAAGIAAALLGALVFGFIQGKIGHRGQEVGYWALCIGLLTGAALGKLGGRAPLLALIGIPLAVAGVSLAQLLGVAVLMGDESSWPTTDTLIGHFGLVMDHWRADILGRNDITFYAVAGAESYLVAKRITE
>NC_015957.1|WP_014054237.1|757545_758259_-|hypothetical-protein
MSQNWQQPQQPGGYPQQPGGYPQQPAPPQQAGGYGTPQPGYGYPQGQPQQPQQPQQQYGGGFPPPAPPVGRPGNPMLAVGAAIVATLVGAFLYAFLLSAMADTDGPEVKVTQFAYAGVIVGALIGFLVAKFGGRNPALWVVGAVLALAAVFLGELYGYAMIMSDLLDKNADQLQSIGMKPMSASEIFFQHFNTPLVKGMPGGGLFDGWKDDSDAMTYIFMALAPVAAVSTAYRISNR
>NC_015957.1|WP_014054236.1|756312_757440_+|GuaB3-family-IMP-dehydrogenase-related-protein
MTEIEIGRGKRGRRAYAFDDIAVVPSRRTRDPKEVSIAWQIDAYRFELPFLAAPMDSVVSPRTAIRIGELGGLGVLNLEGLWTRYEDPEPLLAEIAELDERTATTRMQEIYAEPIKEELIGQRLKEVRDAGVVTAAALSPQRTAQFSKAVVDAGVDIFVIRGTTVSAEHVSGAAEPLNLKQFIYELDVPVIVGGCATYTAALHLMRTGAAGVLVGFGGGAAHTTRNVLGIQVPMATAVADVAAARRDYMDESGGRYVHVIADGGVGWSGDLPKAVACGADAVMMGSPLARATDAPGRGHHWGMEAVHDEVPRGKRMNLGTVGSTEEILLGPSSIPDGSMNFFGALRRAMATTGYSELKEFQRVEVTVAPSARDKS
>NC_015957.1|WP_014054235.1|754725_756228_+|IMP-dehydrogenase
MTDNVDGVPEKFAMLGLTYDDVLLLPGASEVLPNAVDTSSRVSRNVRVNVPLLSAAMDKVTESRMAIAMARQGGVGVLHRNLSIEDQANQVDLVKRSESGMVTDPITVRPDATLHEADALCAKFRISGVPVTDAVGKLLGIVTNRDMAFEVDRGRQVREVMTPMPLVTGKVGISGEDAMQLLRRHKIEKLPLVDDAGVLKGLITVKDFVKAEKYPHAAKDAGGRLVVGAAVGVGDEAYERAQALVEAGADFLVVDSAHGHSRGILDMIAKVKSNISVDVVGGNVATRDGAQALIDAGVDGVKVGVGPGSICTTRVVAGIGVPQVTAIYEAARACHAAGVPLIGDGGLQYSGDIAKAIAAGADTVMLGSLLAGCEESPGEMVFISGKQFKSYRGMGSLGAMQTRGQARSFSKDRYFQDNVLSEDKLVPEGIEGQVPYRGPLASVAHQLVGGLRASMGYVGSANVAELKEKGRFVRITSAGLKESHPHDIQMTTEAPNYSGR
>NC_015957.1|WP_014054234.1|753956_754568_+|sigma-70-family-RNA-polymerase-sigma-factor
MPRDDENPGAAKGAPGGTGPIGALVGRAVEGDEQATHDLLALVHPLALRYCRTRLSRLPGDARHFVDDLAQEVCLAVLCALPRYRDTGKPFEAFVVAIASHKVADLQRAAMRHPGSTAVPSDEMPEQPDDSLGPEERALLSSDAEWAKKLLANLPEHQRELVLLRVAVGLTAEETGQMLGMSPGAVRVAQHRALSRLRALAEQ
>NC_015957.1|WP_003948568.1|753054_753666_+|response-regulator-transcription-factor
MTSVLVCDDSPLAREALRRAVATVPGVERVTTAANGEEVLRRWGADRSDLILMDVRMPGLGGVETVRRLLSADPGARIIMLTVAEDLDGVALAVAAGARGYLHKDASRAELRATVTQALADPTWRLAPRRLRSAEMGAAPTLTAREIQVLEGMSHGRSNAEIGRELFLSEDTVKTHARRLFKKLGASDRAHAVALGFRWGLVR
>NC_015957.1|WP_014054233.1|752331_752646_-|WhiB-family-transcriptional-regulator
MADFSRLPGPNADLWDWQLLAACRGVDSSLFFHPEGERGAARSAREMSAKEVCMRCPVRAQCAAHALAVREPYGVWGGLTEDEREELMGRARHRAVAGTGAPGS
>NC_015957.1|WP_043235356.1|751358_752261_+|LysR-family-transcriptional-regulator
MIEARHLRVLRAVAATGSFSAAARELGCTQPAVSQQMKALEGAAGTPLLIRSGREMRLTEAGRALVRHATGILAGLTAAEEEVAAIAGLRAGRVRLVSFPSGSSTLVPMALAEMRAAHPGTRVSLVEAEPPGSVEMLRSGDCEIALAFRYPQMSEEASGEWDDLVLRPLLNDRLVGVVPEGHKLAGAGAVGIAELAGEPWIAGCPRCRGHLVEVCESEGFTPRIDFATDDYPTVIGLVGAGLGVAVLPELALESVRAKGATTLEVEPAVRREVVALTLPDLARVPAVAATLDRLEQAARR
>NC_015957.1|WP_014054231.1|750608_751277_-|MOSC-domain-containing-protein
MLQTPAVLTVNLGRATPTDYTDWPTGTGIDKRPVERPVRVAAPGPKGQGAGGLSGDTVCDTRHHGGDDQAVYAYAREDLDVWQQELGRELANGVFGENLTTSGIDVSGALIGERWRVGSELLLEVTSPRIPCRTFAGWLGERGWVKRFTQAAVPGAYLRVLEPGEIRSGDPVEIVHRPDHEVTVAFLFRAETTERELLPRVLVAGDALHPEAREAALKYRSR
>NC_015957.1|WP_106685612.1|760583_763061_+|hypothetical-protein
MRRGRTADAGVEVVVVGCGGTYGRAVVATVTTILVAITSVPVTPTGSAEAVGPAPGRGTYGVTAAQGRSRAYGVTAAQGRSRAYGVTAAQGRSRAYGVTAAQGPSRSYGVTTAQGRSRAYGVTAAQSPSRSYGVTPAQSHSRSYPVSVELASLTPAVIRQGGDLRITGRVTNTSGRRLGPAHIGVRIGASGAIDTRGGLSAVARRAPLTRADGPEVPGRTARLAALPTGAERGFRLTVPVPDLELDDAGAYALTVDVVREGGPGAGTVLGLTRAHLSAYPDATRLEPLRTTVLWPVLDIPRMEALTLRTQDSVLPVFRDDELTAAFGPGGRLRRLVEMGKGQPVTWVLDPDLIVQARAMAAGYRVARTPGDSDPQEATEGEGGEAAADWLAALRRAVRGREVIALPYADPDLASLARGGGAPLASLLRRASHTGRSVVDRALGVRARTGVGWPAGGELDDGIARYAKELGLDTVLASGAGVASEGELVSEGATDDGAVSLEGGTTALRYDAAIAAQLFASHPAAGASGEPARLLLRQRLLAETLTAARELPYARRELVMVPPRRMPLAVARVLLTVVAEGRKAGWLEPAGFTAALRKPTAGRLRGFDGYPLARHASELPPARLAAVVRDRRRMRALAKVLSDARATAASVRAALARSVATAWRADPSGAASYQRGVSRYLTASIASVRLVPKSMVVVAGGSATIPVTVDNGLQQDLTGVELRVLSSRPERLNARDRAMPVRASRAVSRTVRIRVKAYANGPVRLTAQLYTTADGLPWGAPMTFTANVRSVPSGAVIFVLGGTALIVLAAAFRPRRAGRARRAGRR
>NC_015957.1|WP_014054241.1|763330_764605_-|nucleotide-sugar-dehydrogenase
MPADLAVIGLGHLGIPLAQAATAAGVRTVGYDPDPRAAADLRSGRLPSGSGGEGRLSAAELRRMASQGFRITADPAELGRVRTAVICAPTPLGDDRRLDLSAVGEAARTLAARLRPHTTVLLESTVYPGTTEEFLRPLLEEGSGLRAGRDFHLAYSPCRHDPGNRAHGPANTPKVIGGLTPACTEAAAAFYGRFTEKVVRARGTREAETVKVLETNYRHVNIALVNEMAVYCHDLGVDVWDVVRCAETKPFGFQSFRPGPGVGGHGVPVDHGHMADQQRGLGLPLRMVELAQQVNGRMPGYVTRRCTALLNEYGKSARGAHVLLLGVGYKADVADAEGSPAREIASRLIELGARLSYHDPYVARWRVLGREVERADSVYEAAADADLTVLLQPHRTYDLQGLAVKAQLLLDTRGAGPAGTAHRL
>NC_015957.1|WP_014054242.1|764811_766518_+|glycerol-3-phosphate-dehydrogenase/oxidase
MKTPALGPAERGEALARMADRELDVLVVGGGVVGAGTALDAATRGLETGLVEARDWASGTSSRSSKLIHGGLRYLEMLDFALVREALKERGLLLERIAPHLVKPVPFLYPLKHRAWERLYAGSGVALYDAMSISSGHGRGLPTHRHLSRRRALQVAPCLKKDALVGALQYYDAQMDDARYVATLVRTAAKYGAQVANRARVVGFLREGERVVGARVRDLEQGGEFEVRARQVVNATGVWTDETQALIGERGQFHVRASKGIHLVVPKDRIHSTTGLILRTEKSVLFVIPWGRHWILGTTDTDWDLDKAHPAASSADIDYLLEHVNEVLAVPLTRDDVEGVYAGLRPLLAGESDATSKLSREHTVAHPVPGLVVVAGGKYTTYRVMAKDAVDEAVHGLDRRVGPCVTEEIPLVGAVGYKALWNARERIGRQVGLHVARIEHLLNRYGSATQEVLDLIAADPSLGKPLAGAEDYLRAEIVYGVSHEGARHLDDVLTRRTRISIETFDRGTRCAREAAELMAPVLGWGEDQTGREVQHYEKRVEAERESQRQPDDLTADAARLGAPDIIPL
>NC_015957.1|WP_014054243.1|766552_767785_-|serine-hydrolase
MPISAIRWHRRSRMPTAVALTAALGLALSGCGTAATGTGRDADPRANEGAGGGHGGAGGGHGGAVRTAVRRLAAQGDAPGAGVLIRRKGGGTRFIAAGVADVRTGRRIHRSDHFRAGSLTKTVMAAVTLRLAAQKRLGLDDTVEKHLPGLVRGHGNDGRNITIRQLLNHTSGLFDYTEDPALARQLSAAADRTRTPASLVRTALTHRPYFAPGSKWRYSNTNYVLLGMVVQRATGHSYAAEARREELDPLRLHGTSFPGTRTTLPAPHGRAYTRDGGARDSEARSDGARRDVTDLNPSFAGAAGELVSTLDDLSRLLSGLLRGTVVPPAELRQMRNTSASDGQYGMGLFPVRLPCGVTLWGHNGEINGSYALAVATPDGRHTLAYRLNSTAGSGLTGETSLLEAEFCPRR
>NC_015957.1|WP_014054244.1|767946_769950_+|serine/threonine-protein-kinase
MSEAEKTQGSTGRLLAGRYRLGEILGQGGMGTVWRASDQTLGRTVAVKELRFPSSVEEDEKRRLITRTLREAKAIARIRSNGAVTVYDVVDEDDRPWIVMELIEGRSLADVVRDDGPLTPRRAAEVGLAVLDVLRAAHQAGILHRDVKPSNVLISDDGRVVLTDFGIAQVEGDPSVTSTGMLVGAPSYISPERARGQKPGPPADLWSLGGLLYAAVEGVPPYDKSTAIATLTAVMTEPVEPPKNAGPLEEVIYGLLTKDPALRLDEAGARVLLEHAVSAPEETKVPADATRTMSLPPAPSAEDEAAAEAKEPGVSERRRGALKSVRNAAATAATKKADSGSAAGPAEKSGASGTAKAGAAKSGAAKSGAAAKAEPAAATPAGAPAPRPAAPPRASITDVVPRRTLIIIAVVVVLAIVGTVLAVVLSNGGDGDKAKGASGGDKSTSAGASGGAKDDQGADKAGQSEGASPKAGSSGRKSGSQPGTDASESSDDNSGKGGGGSGDDSGKGKGGGGKGGLPDGYQTVKSADFPFSMAMPEGWSVHSGSYAGSRKYYGGSSVPRIQIDFTNAPRSDAEADWRKGEDNARRTMAGYKGLGIKSIDWRGYPTVADWEFERDQDGKRVRVLNRGFKADGSHGFAILITCEASKWNDKECATLRQTAFNTFKITD
>NC_015957.1|WP_014054245.1|770108_772937_+|protein-kinase
MEEYAGRVLADRYRLPLPPADEYELIETRAFDTYSGQEVHLRQIPLPEVVDAEVVDEDARWGGGGPSGRNGTFAGAGRTARGGGDPAVRRAIAAATSAAQIPDHPRLGQVFHVFAEAGSLWIVSELVSGRPLAALLAEGTLSPHRAAEVANDVLTALGALHAHGWVHRNITTRTVLLCDDGRAMLMGLAAGAAEEALCGYDPVPAPASSPSTGDPAAEEPRPDETPAALPQGPEGSGDQPDRPQGQAGRGDEGRVAIPGARTGEGGEARPNGGPRYRDQGPAGGFLPPGGPYGGHEPAGAGSRPDAEGREHSGHGTETGLPESRTPYGDHGAAEASSGPGLGGPVYRDQVTFGPGTGGPMAPYRDKGAAGGLPGPRRAGQPGSREGEPGGTGADAPSAAARAARASAIAAYAAGARAAARANVEAATRSPHAPEPAPAATPEPEPEPGGAPWPGQPDREESAQPAASEGGGSWDTGGAAAGGPATALAAERARQARIVVVGAVTERWAPEQAGPVHENWRLAPPVGPAADLWALGALLFRAVQGHAPYPEESAAELVQMVCGEAPAYAEECGPLRPVVESLMRQDPTERPDFEELRGWLRSLIRSAPEPDVGSSTVTVPSLGAGGASDPRRLPIVRRRGWLVRRGRGRRPAAAADAAAGHARHRRDKREKREVREARAPRETRATRAPREKTEPREARETRQASAPAQRKPRRLGRMLLLLIFLVLAAAVVYAMMFMPRAKDDDGQGRTGSAGTPSAAPHDPAGGDGNEGKAGKPADPGDQEPQSTDPAGLAKGFAVRKDPKGFKVAVHEDWTRRGENGRGQIRYIGGDFELVVVAGRDKMSEFGGDPMAYQQDREAELAAFRGSSWASSSGLRRIDVGRTAMAEGSFSWRDSSGRNVYARNLAMLIDGRYHVVLVIGPSDERSAVNRYFEQATATYSTTNG
>NC_015957.1|WP_014054246.1|772933_774568_-|AMP-binding-protein
MTDVAQDAQELGSSATLWELLERRAALTPDAPALLQAGASARHDRRLTFGALRTRAERTAAGLYRMGIGPGSRVAWQLPTRIETVVLTMALARLGAVQTPLIPYYRDREVRFALRESGARFFAVPGHWRGVDHTAMARRLAAELPEPPLVFEAYDTLPVADPKALRLPPPPTDGRAVRWIYWTSGTTSDPKGVLHTDRSLIAAGACLAHALRLGPDDVGSMAFPYAHVAGPDYTVMLLLYGFPAVLLEHFSLPESLPAYRRHGVTVAGGSTAFYSMFLAEQRKDPSRRLIPTLRLLAGGGAPKPPELYYEVVRELGCTLTHGYGMTEVPMITMGAPDDTDENLATTEGRPPREMEIRVVDGQVGLRGEAVCAGYLDDAETRKAFDADGFFLTGDLGHLTESGHLVLTGRAKDIIIRKGENISAKEIEQLLYQHPDVGDVAVIGLPDRDRGELVCAVVEQPAGAEALTLGRAVSYLRTAGLSVHKLPERLEVVDALPRNETLRKVLKYRLRERFAEHGAQAAWDGAQAAREEAQEKPRPGTTPER
>NC_015957.1|WP_014054247.1|774804_775968_+|acyl-CoA-dehydrogenase
MDLAFTEDEEDFRHRLRAWLADALPMLPDRPHPADWPGRRAYDCGWQRMLHDAGYAGLHWPKDAGGQGATPTQHLIFLEETERAGAPYVGAGFVGLLHAGPTIAAEGTPEQRARWLPPILRGDEVWCQGFSEPDAGSDLASLRTRAVRDGDTYVVNGSKIWTSHAEIADWCELLVRTAPVNADTPKHRGITWLAMPMDAPGVTVRPLRTLAGTAEFAEMFLDEVRVPVTHRVGEENDGWRVTMVTLSFERGTAFVGEVVACRRVLEALARTAKANGRWDDAVLRRRLGRLAAECAALWRLTQWNVSEAQRTGGVPGVGGSVFKLRFSQVRQELYEAAAEVLGPDALDAGQEWVADRLSSLSYTIAAGTSQIQRNIVAERILGLPKGR
>NC_015957.1|WP_014054248.1|775976_776981_+|acyl-CoA/acyl-ACP-dehydrogenase
MDFQLTDDQRALRAGMRELLERRFPRTRLRAAVDGDTERSAELDRALWRELGAAGLFALRVPESAGGVGLGLPEAVLAFEEAGRALLPGPLVATELAAGLSAALAAGAVQGETVVTALDEEGARAPVEHLASADAVLALGSTAVELIPAAEVARAAEPMRSVDPATPLHRTAPTRTRQDQAGPGRSGIAARLRREAALLTAAQQLGSASRTVELAVDHAKRRTQFGRPIGAFQAVQHLCAQMLVRAESSRSVVYAAAVTEDPGDIAAAKLLADEAAVHNARDCLQVHGGMGFTWEADVHLHLKRAWVRAGQWQCAAAAEEELAAGLVSTVETCL
>NC_015957.1|WP_014054249.1|777446_778019_+|ATP-binding-protein
MQVLQAQMEVRPDPAEVSRARRWARSRLVGSGIGADEPLAETLILLISELVTNAVVHTGCPAVLRMLFPAQSMGGGGGGGNGGGVGGGGAPGPFVSRGAGLGTVRVEVADVSDRAPRQRCADEEDTHGRGLELVDGLADRWGWQPEGSGKRIWCEIDRAKGEEPLSRRRAASHAPSHIGRTRQSPDQVLT

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Crispr_ID: NC_015957_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015957_6

1270514-1270614

Orphan

Consensus_repeat	Method
GGGTACCAGGGGCGAAGCCCCTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015957_6

>merge|NC_015957|6|1270514-1270614|CRISPRCasFinder
GGGTACCAGGGGCGAAGCCCCTGCCAACCCAGCCCCTCCGGCGTTTGAGGAGCGGGGTCCGGGGCGGAGTCCCGGCGGGGGTTCCAGGGGCGAAGCCCCTG

>NC_015957|6|6|1270514-1270614|CRISPRCasFinder
GGGTACCAGGGGCGAAGCCCCTG	CCAACCCAGCCCCTCCGGCGTTTGAGGAGCGGGGTCCGGGGCGGAGTCCCGGCGG
GGGTTCCAGGGGCGAAGCCCCTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_015957.1\|WP_014054677.1\|1281149_1281350_+\|DUF397-domain-containing-protein	unknown	unknown	gnl\|CDD\|377231
NC_015957.1\|WP_014054664.1\|1264752_1266708_-\|fumarate-reductase/succinate-dehydrogenase-flavoprotein-subunit	unknown	unknown	gnl\|CDD\|236101
NC_015957.1\|WP_014054667.1\|1268242_1270405_+\|ABC-transporter-family-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173866
NC_015957.1\|WP_014054666.1\|1267650_1267935_-\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_106685626.1\|1258184_1259795_+\|APC-family-permease	unknown	unknown	gnl\|CDD\|223605
NC_015957.1\|WP_014054660.1\|1259980_1260166_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236733
NC_015957.1\|WP_014054665.1\|1266723_1267575_-\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014054676.1\|1280246_1281137_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197775
NC_015957.1\|WP_014054668.1\|1270784_1272680_+\|translational-GTPase-TypA	unknown	unknown	gnl\|CDD\|273597
NC_015957.1\|WP_014054671.1\|1275898_1276876_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NC_015957.1\|WP_014054675.1\|1279651_1280089_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|340413
NC_015957.1\|WP_014054674.1\|1279229_1279589_-\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014054662.1\|1261215_1263909_+\|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272
NC_015957.1\|WP_014054670.1\|1274979_1275906_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NC_015957.1\|WP_086019668.1\|1277968_1279108_+\|dipeptide-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|185037
NC_015957.1\|WP_014054661.1\|1260444_1260969_+\|(deoxy)nucleoside-triphosphate-pyrophosphohydrolase	unknown	unknown	gnl\|CDD\|239517
NC_015957.1\|WP_014054672.1\|1276887_1277946_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223521
NC_015957.1\|WP_014054658.1\|1256116_1257862_+\|allantoin-permease	unknown	unknown	gnl\|CDD\|224374
NC_015957.1\|WP_014054663.1\|1263985_1264756_-\|succinate-dehydrogenase/fumarate-reductase-iron-sulfur-subunit	unknown	unknown	gnl\|CDD\|237086
NC_015957.1\|WP_014054669.1\|1273187_1274831_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173853

Protein	Function_ID	Function_description	E-value
NC_015957.1\|WP_014054677.1\|1281149_1281350_+\|DUF397-domain-containing-protein	gnl\|CDD\|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	1.58416e-14
NC_015957.1\|WP_014054664.1\|1264752_1266708_-\|fumarate-reductase/succinate-dehydrogenase-flavoprotein-subunit	gnl\|CDD\|236101	PRK07803, sdhA, succinate dehydrogenase flavoprotein subunit; Reviewed.	0
NC_015957.1\|WP_014054667.1\|1268242_1270405_+\|ABC-transporter-family-substrate-binding-protein	gnl\|CDD\|173866	cd08501, PBP2_Lpqw, The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold. LpqW is one of key players in synthesis and transport of the unique components of the mycobacterial cell wall which is a complex structure rich in two related lipoglycans, the phosphatidylinositol mannosides (PIMs) and lipoarabinomannans (LAMs). Lpqw is a highly conserved lipoprotein that transport intermediates from a pathway for mature PIMs production into a pathway for LAMs biosynthesis, thus controlling the relative abundance of these two essential components of cell wall. LpqW is thought to have been adapted by the cell-wall biosynthesis machinery of mycobacteria and other closely related pathogens, evolving to play an important role in PIMs/LAMs biosynthesis. Most of periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the LpqW protein. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	7.49747e-87
NC_015957.1\|WP_086019668.1\|1277968_1279108_+\|dipeptide-ABC-transporter-ATP-binding-protein	gnl\|CDD\|185037	PRK15079, PRK15079, oligopeptide ABC transporter ATP-binding protein OppF; Provisional.	5.80147e-156
NC_015957.1\|WP_106685626.1\|1258184_1259795_+\|APC-family-permease	gnl\|CDD\|223605	COG0531, PotE, Amino acid transporters [Amino acid transport and metabolism].	2.06195e-56
NC_015957.1\|WP_014054660.1\|1259980_1260166_+\|hypothetical-protein	gnl\|CDD\|236733	PRK10672, PRK10672, endolytic peptidoglycan transglycosylase RlpA.	0.00707645
NC_015957.1\|WP_014054676.1\|1280246_1281137_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	9.13029e-09
NC_015957.1\|WP_014054668.1\|1270784_1272680_+\|translational-GTPase-TypA	gnl\|CDD\|273597	TIGR01394, GTP-binding_protein_TypA/BipA_homolog, GTP-binding protein TypA/BipA. This bacterial (and Arabidopsis) protein, termed TypA or BipA, a GTP-binding protein, is phosphorylated on a tyrosine residue under some cellular conditions. Mutants show altered regulation of some pathways, but the precise function is unknown. [Regulatory functions, Other, Cellular processes, Adaptations to atypical conditions, Protein synthesis, Translation factors].	0
NC_015957.1\|WP_014054671.1\|1275898_1276876_+\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	4.12393e-84
NC_015957.1\|WP_014054675.1\|1279651_1280089_-\|ATP-binding-protein	gnl\|CDD\|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	1.3484e-15
NC_015957.1\|WP_014054662.1\|1261215_1263909_+\|SpoIIE-family-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	8.94501e-51
NC_015957.1\|WP_014054670.1\|1274979_1275906_+\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	2.7778e-104
NC_015957.1\|WP_014054663.1\|1263985_1264756_-\|succinate-dehydrogenase/fumarate-reductase-iron-sulfur-subunit	gnl\|CDD\|237086	PRK12386, PRK12386, fumarate reductase iron-sulfur subunit; Provisional.	0
NC_015957.1\|WP_014054672.1\|1276887_1277946_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.50171e-179
NC_015957.1\|WP_014054658.1\|1256116_1257862_+\|allantoin-permease	gnl\|CDD\|224374	COG1457, CodB, Purine-cytosine permease and related proteins [Nucleotide transport and metabolism].	2.52723e-15
NC_015957.1\|WP_014054661.1\|1260444_1260969_+\|(deoxy)nucleoside-triphosphate-pyrophosphohydrolase	gnl\|CDD\|239517	cd03425, MutT_pyrophosphohydrolase, The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic pyrophosphate (PPi). This enzyme requires two divalent cations for activity; one coordinates the phosphoryl groups of the NTP/dNTP substrate, and the other coordinates to the enzyme. It also contains the Nudix motif, a highly conserved 23-residue block (GX5EX7REUXEEXGU, where U = I, L or V), that functions as metal binding and catalytic site. MutT pyrophosphohydrolase is important in preventing errors in DNA replication by hydrolyzing mutagenic nucleotides such as 8-oxo-dGTP (a product of oxidative damage), which can mispair with template adenine during DNA replication, to guanine nucleotides.	9.10261e-38
NC_015957.1\|WP_014054669.1\|1273187_1274831_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|173853	cd00995, PBP2_NikA_DppA_OppA_like, The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold. This family represents the periplasmic substrate-binding domain of nickel/dipeptide/oligopeptide transport systems, which function in the import of nickel and peptides, and other closely related proteins. The oligopeptide-binding protein OppA is a periplasmic component of an ATP-binding cassette (ABC) transport system OppABCDEF consisting of five subunits: two homologous integral membrane proteins OppB and OppF that form the translocation pore; two homologous nucleotide-binding domains OppD and OppF that drive the transport process through binding and hydrolysis of ATP; and the substrate-binding protein or receptor OppA that determines the substrate specificity of the transport system. The dipeptide (DppA) and oligopeptide (OppA) binding proteins differ in several ways. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Similar to the ABC-type dipeptide and oligopeptide import systems, nickel transporter is comprised of five subunits NikABCDE: the two pore-forming integral inner membrane proteins NikB and NikC; the two inner membrane-associated proteins with ATPase activity NikD and NikE; and the periplasmic nickel binding NikA, which is the initial nickel receptor that controls the chemotactic response away from nickel. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand binding domains of ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	3.03432e-115

>NC_015957.1|WP_014054667.1|1268242_1270405_+|ABC-transporter-family-substrate-binding-protein
MPLTKRRRAMLLAAGVMLPLPVLTGCSSDDDGPPPPAAWDVASAPRSATAGTGTLHWALDAAPTTLNAFQKTADTGTQRIAGAVLPSLYTLDARGRPQRNGDYLTAADVTSSDPKQVVVYKLNPKAVWSDGRPIGAEDFQAQWRALRGTDEAYGTARNAGYDRIAKIEPGDKEHEVKVTFAKPYTDWRSLFTPLYPKSVMGNPAVFTAPATKGLAVGAGPFMVREVSDGSVTLVRNPRWWGDRARLNRLVFQAVPADQRDEALIDGQLDLAEVDRATARRIRATAPDKQAAGTKQGSSAPGKAGAPEQSTGGREAAGAEGGATGDTDKATGDTDDTDKNRSQTRALSRFTLRKALDSAYTQLALNGTKGPLADERVRRAVARAIDRKALAKLVLKPMGLPSEPLGNHLLMAGQPGYKDHSGALGDKDTNAAQSLLADAGWRAGDAGRQKALDGKTDDRGRRHSAPTATATDPATDGAPGTDLASDSATGTDPATDSASGSASQSASGTASTSATNSATNSERPSDAAPAAGDAGRSGRLGEAAVVRKKGRPLVLRFVLPDDRTAAPLSTVGERIARMLEKIGVRTEITKVPGESYFRDHIATGDYDLALYSWPASAYPATDGRPIYAKPQPAADGSLVVEQNYTRVGTDQIDQFFDQALSELDGGASRSLVSRADARIWAAAGSIPLYQRPQLIAMRKDLVNAGAFGFATPRYQDIGFRR
>NC_015957.1|WP_014054666.1|1267650_1267935_-|hypothetical-protein
MSLTDDLTAVQRCLDDLVRSVSRLEQRVGAGGLEIRRVRTDADHLRESLALLRETAPEERPRPEMVPVPDAPYDSALWSDVDDEGLGARDRHAP
>NC_015957.1|WP_014054665.1|1266723_1267575_-|hypothetical-protein
MATGTDPQATTPAPADRGTAPHGVHGASRAAIPARHLRSDRWWLSPAITAAGLFAFIVYSTWRAFAGDDYYAEPYVSPFYSPCVAQNCVPMKGGANWEIFGAWWGLSPALLILIFPLGFRLTCYYYRKAYYRGFWASPPACAVAEPRAKYTGETRFPLVLQNIHRYFFYFAVIVAGILTYDTVLGFRDEHGRWGHMGLGTLVLLANIALIWAYTLSCHSCRHIVGGRMKHFSRHPVRYRLWGWVSGLNARHMQLAWASLISVAVADFYVYLVASGAFDDPRFF
>NC_015957.1|WP_014054664.1|1264752_1266708_-|fumarate-reductase/succinate-dehydrogenase-flavoprotein-subunit
MTQVERQAWDVVVIGAGGAGLRAAIEAREQGMRCAVICKSLFGKAHTVMAEGGIAASMGNVNERDNWQVHFRDTMRGGKFLNHWRMAELHAQEAPDRVWELETWGALFDRTPEGKISQRNFGGHEYPRLAHVGDRTGLELIRTLQQKIVSLQQEDKAETGDYESRLKVFQECTVTRIVKDGDRVAGVFGYERESGRFFAIEAPAVVLATGGIGKSFKVTSNSWEYTGDGHALALLAGAPLINMEFVQFHPTGMVWPPSVKGILVTESVRGDGGVLRNSEGKRFMFDYIPDVFKEKYAQSEGEADRWYEDPDNNRRPPELLPRDEVARAINAEVKAGRGSPHGGVFLDVSTRMSPEVIKRRLPSMHHQFKELADVDITAEPMEVGPTCHYVMGGVDVDPDTAAATGVPGLFAAGEVAGGMHGSNRLGGNSLSDLLVFGRRAGLHAARYAQETAASGTRPVPDETQLDLAAAEALRPFSAEAGEPDESAGPAGPPENPYTLHQELQQSMNDLVGIIRKAGEMEEALHRLASLRVRARRAGVEGHRQFNPGWHLAIDLRNMLLVSECVARAALERTESRGGHTRDDCPEMDREWRRLNLVCRLSDPSGGLAAPDTGHGQIRLERRETPPIRPDLLNLFEKDELVKYLTDEELTQ
>NC_015957.1|WP_014054663.1|1263985_1264756_-|succinate-dehydrogenase/fumarate-reductase-iron-sulfur-subunit
MNAYEAHFRVWRGDQDGGGLKDFHVEVNDGEVVLDIVHRLQATQAPDLAVRWNCKAGKCGSCSAEVNGRPRLLCMTRMSVFDRAETITITPLRAFPVVRDLVTDVSFNYTKAREVPSFVPPEGVGPGEYRMWQEDVGRSQEFRKCIECFLCQDTCHVVRDFEENKEAFAGPRFLMRVAELDMHPLDAAADTGLDRKRTAQEEHGLGYCNITKCCTEVCPEQIKITDNALIPLKERAVDRKYDPLVWLGNKIRRRGQ
>NC_015957.1|WP_014054662.1|1261215_1263909_+|SpoIIE-family-protein-phosphatase
MSEKPAGADIPEETVGSQVSPVSQGSSVPDMSPMSSMSAVWQSSPPGSIYDYIQVASFALGSDGRIAQWSERAAELLGLTARQAIGKDPVEAFVPPEYQETGHRAVADILDGREWTGLVPYRSPQAPSGHGIAEVYVMPAQDEDGKRAALCIAVDVSALRGLETDLASSQAVFGQSPLGFFLFGTDLRMLRVNERFAKVFGRPTEEYRGVTPHDLLPRGEADRLAAALRQVLDSGQALTDMPLMGQTPGSTDRRRWSVSLYRLHSGSGRPIGIAGLATDVTGRRRAEQEAAGVRRNLALLNEAGARIGTSLDLETTARELLDVAVPQFCDLASVDLYQGLLSGDETPPGLADGSAELRRVAFASAVSDGPVPFGDICRVNTAEDPKPIQVGEVHRYPFNSLCAHALRTAQVRVVPGRDGSESLELGAMLQSTLVVPMVARDTVVGLAQFSRTKGSEPFGERDRALAVELAARAAVSIDNARLYRREHERALILQRSLLPPGDPEAAGLDIACRYLPGNAATEVGGDWFDVIELPGHRTALVVGDVMGRGLRAAVAMGELRTAVRTLALLDLEPAEVLSALDEIALGLGTPGGSHSGARPGSRARGKAADDSSDLTEVYLATCVYAVYDPVTRRCTFANAGHPPPVLVEPGENALLMEVPPGMPLGVGGEPFEEIEVELPDGALLALYTDGLVESRDHTLDEGLQALRAALDTPDGADGGNAAAGSLEDVCDHVLSTLDTHHGEDDIALLMARVQGLSAESVGDWHLPSAPQSVGRARELAREQLESWGLDGLVDTTELLVSELVTNALRYGEGEIRLRLLLDRTLVCEVWDGGLVQPRRRRARDTDEGGRGLQLVGLLSAGWGSRRTPLGKTVWFELALPDGRSSEPDSVEALLSLW
>NC_015957.1|WP_014054661.1|1260444_1260969_+|(deoxy)nucleoside-triphosphate-pyrophosphohydrolase
MSVRVVVGGAVFDRGRLLAARRSAPPELAGRWELPGGKAEPGETPPQTLVRELREELGVEVEPLEPLPGEWPLKPGYVLRVWTAALRSGEPRPLEDHDELRWLPPDRVDEVDWLDEDRPAVAEAVRRLRAAEGAGQGAEQRAGQDREQGAGQGPEQGPEQRAGQGTEGAPPRTP
>NC_015957.1|WP_014054660.1|1259980_1260166_+|hypothetical-protein
MSDGNAVLPWLVIRQDTNGNRYRVGRYATRTEAQEVADRLEGQGQEQLYVVERTAASRQSG
>NC_015957.1|WP_106685626.1|1258184_1259795_+|APC-family-permease
MALTAVGLGSIIGSGWLFGAERAAALAGPAAILAWVIGAAVALTIALTYSELGSMFPKAGGMVRYGQYSHGSLAGYLAAWANWIAIVSVIPGEATASVQYMSSWDFGWAKALYDGKELTGSGVALASVLLLFYFFLNWFAITLFAKTNTAITVFKLVVPTLTAGALLLSHFDTGNVTGHGGFTPNGWSSVFTAVAVSGIVWAYNGFQSPLNMAGEARNPGKSLPKAVISSILISLVIYVALQIAFLTAVPAADLAHGGWSGLSFNSPLADLSLAWGLNWLAMLLYADAFISPSGTGMIYAATTSRMIQGVQENGHLPSIFGKVDPKTGIPRPALLLNLGIAFIFLAVFRGWGSLAEIVSVATVISYITGPVAVMSLRRLSPDLPRPVKLRAMPVIAPVAMVFGSLVLYWARWPLTGKVIFIMAIGLPIWAWYELRKPWAQLRPHLAAGAWMVTYLLVMAAVSWAGGKEFGGRGYLPGGWDILVVALIGLAFYVWGVRSAWRNPTLLEAERELGTAPAGEDGEGSEDDGRAKADARV
>NC_015957.1|WP_014054658.1|1256116_1257862_+|allantoin-permease
MTDAVDAVGTVDAVDTAAPEAGASAAAAPRRGYARLAADESREDYSLRYAPHSYRRWSPTMVASTALGGIAYLADFAIGASIVFTYGFSSGIASILTAATIIFLTGIPIARACATYGLDMDLITRGAGFGYFGSTLTSLIYASFTFIFFALEGSIMAQAMHQALHIPLPVGYLLTTLIVIPIVFRGMGALAKVQAWTQPIWLIGLALPFVVLAFEAPDSWGAFASFGGTEGAGSGFDWIGYGLGTGVALSLIAQIGEQADYLRFMPAKTEENRRRWNLAVLAAGPGWVVIGAAKQIGGAFLAFVALGAVGKTHALEPIAPQIEALKPWLGSVALPAAALFVVVSQIKINVTNAYSGSLSWSNFFSRVTHRHPGRVWYIFLNLAIALALMEMNMFAALNKLLGFYSNVGIAWIAAVAADLVINKPLGLSPEYIEFKRAYLHPVNPAGFGAMVIASTVSIIAFFGAFGEVAEAFSTFIACGLALVLCPLLAWLTGGRYYLARRNPVNGPGVEVPDITATHRCASCQTAYELPDIADCPVRAGAVCSLCCSLDAECGDVCRKAPTGEPVLMPLPTVRTRSATGT
>NC_015957.1|WP_014054668.1|1270784_1272680_+|translational-GTPase-TypA
MPTRHDIRNVAIVAHVDHGKTTLVDAMLKQAGAFAAHQHVDDRVMDSNDLEREKGITILAKNTAVKYHPADGGDPVTINIIDTPGHADFGGEVERGLSMVDAVVLLVDASEGPLPQTRFVLRKALQAKLPVILCINKTDRPDSRIDEVVNEAYDLFLDLDATEEQIEFPIVYACARDGVASLTKPEDGTVPADSDSLQPFFSALLETVPAPEYDAAAPLQAHVTNLDADNFLGRIALLRVEQGELKKGQTVAWIKRDGTISNVRITELMMTEALTRKPAEVAGPGDICAVAGIPDIMIGETLADPENPIALPLITVDEPAISMTIGTNTSPLVGRGPGGKGADKSAVKDRKVTARLVKDRLERELIGNVSLRVLPTERPDAWEVQGRGELALAILVETMRREGFELTVGKPQVVTREIEGKLHEPIERITIDVPEEHMGAVTQLMGTRKGRMDNMSNHGSGWVRMEFIVPSRGLIGFRTEFLTATRGTGIAHSIHEGHEPWFGELKTRNNGSLVADRSGAVTAFAMTNLQERGVLFTSPGTEVYEGMIVGENSRADDMDVNITKEKKLTNMRSSTADVTESLVPPRLLSLEQSLEFCRDDECVEVTPETVRIRKVVLDQKERARSAARAKR
>NC_015957.1|WP_014054669.1|1273187_1274831_+|ABC-transporter-substrate-binding-protein
MRGAKSAKWVALAAVVALAATACGGNGSDSGSNDMNKGAADPNGILTAQLSEPQNPLQPANAKESQGSRVLRTIFAGLVDYEPGTGKLVYVNAESVTPNKDSSVWTVKLKPGWKFHNGEAVTAKSYVDSWNWSANVSNNQTNSSWFQDIKGYEDVHPEKGKPKADKMSGLKVVNDNEFKIELNSSVSYFAYKLGYDVWTPLPTGFFKDPKGFGEKPVGNGPYKFVSWDHKKMIKVRKFDGYQGPNKAKNGGIDFKNYTTADAAYSDLRSNNLDWIEQVPTTALTNYKSDLGKRAIDEEYSAVQSVVPAFYTKQFKNIDPKVIQGLSMAIDRDTITKTVLHGSRTPADSFVARGVIGYKAGALKDQVTYDPAKAKALVKEGGGVPGNKISIQFNADQDHKPWVDAVCNSIRKATGVDCVGDSKPDFQADLNARDKHQVKSMYRGGWVLDYPVNSNFMRDLYGSKAAGNTSGYANKQFDELANKADKAATLDETVKLYQQAEQVLAKDMPAIPLWFYKVNSGQSNKVRGKIPYGQDGDPIFTDVQVKKK
>NC_015957.1|WP_014054670.1|1274979_1275906_+|ABC-transporter-permease
MGRYVARRLLQMIPVFIGTTLIIFLMVHVLPGDPIRAMWGDKAADPAQVASLRHEFGLDQPLWRQYIDYMVNLFQGDFGKTFGGREVSEEMGMAFPVTLRLAAVALTIEIIVGIGLGAWAGLKAGRAVDTGVLIFTLIVISMPVFVLGYLARFIFADELGWLPPNVQDSTNLEQLLLPGFVLAMLSMAYVARLTRTTFAENLRADYMRTALAKGLPRRRIIGVHLLRNSLIPVITFLGTDIGALIGGAVVTEGIFNVQGVGNLLFKALGQREGTTIVGTVTIFVLVILLINLVVDLLYAVLDPRIRYA
>NC_015957.1|WP_014054671.1|1275898_1276876_+|ABC-transporter-permease
MPDMTKSQSGTAVDTAVDAVAPPTEVDTAPAAGPVSQGKPRSLWGDAWFELRHRPLFWVSAVLLVLLLSIALFPGLFTGADPKDGDLTNHFLTKPELTHFFQADWFGYDGQGRSIYARVIYGTRASIMVGVGVTASVTIFGGLLGMLAGYFGGWIDSIVSRIVDIFFGLPFLLGSMVVLNAFTERKVYVVIAALAFLGWTTIARVMRSSVITAKQADYVTAARALGAGTNRILFRHVLPNALAPTIVVATISLGAYISAEATLSYLGLGLADPTISWGIDISSAKDAIRDNPHVMLFPAGMLSLTVFAFITLGDAVRDALDPKLR
>NC_015957.1|WP_014054672.1|1276887_1277946_+|ABC-transporter-ATP-binding-protein
MTTIEKTADDAVREGAGDDGTPLLEVRDLHVEFHTRDGVAKAVNGVNYSVDAGETLAVLGESGSGKSVTAQAIMGILDMPPGKIPQGQILFRGEDMLTMSGEERRKIRGRRIAMIFQDALSSLNPVLSVGYQLGEMFRVHQGLSKKDAKAKAIELMDRVRIPAAKERVSDYPHQFSGGMRQRIMIAMALALEPDLIIADEPTTALDVTVQAQVMDLLAELQREYNMGLILITHDLGVVADVADKIAVMYAGRIVETAPVYELYKRPAHPYTRGLLDSIPRLDRKGQELYAIKGLPPNLLKIPSGCAFNPRCPKAEDICRTDVPALVPVTEQDGTELPGRGSACHFWKETLHG
>NC_015957.1|WP_086019668.1|1277968_1279108_+|dipeptide-ABC-transporter-ATP-binding-protein
MEPAAEPAVDATPNVTEVETVDAATEDEAVAALDAKVDRGEPILQVRNLVKHFPLTQGILFKRQIGAVKAVDGISFDLYQGETLGIVGESGCGKSTVAKLLMTLETATAGEVFYKGQDITRLSGRALRAVRRNIQMVFQDPYTSLNPRMTVGDIIGEPFEIHPEVAPKGDRRRKVQELLDVVGLNPEYINRYPHQFSGGQRQRIGIARGLALNPEIIICDEPVSALDVSVQAQVINLMEGLQDEFNLSYIFIAHDLSIVRHISDRVGVMYLGKMAEIGSDTEIYDHPTHPYTQALLSAVPVPDPQSREGRERIILTGDVPSPANPPSGCRFRTRCWKAEDKCAKEIPLLAIPERFAGSDSPAAHESACHFAEEKDVVHA
>NC_015957.1|WP_014054674.1|1279229_1279589_-|hypothetical-protein
MSTQPIEDSHDEPLFPMPPLTEQALRVAVRSLDLGAAVRFEEEFHSAWQEAVQTDSTVPMHTFLHRWGVFVALRRHPDRARRLYELEAAVADAPSIEDARRASAEIGVLLDAARREVAA
>NC_015957.1|WP_014054675.1|1279651_1280089_-|ATP-binding-protein
MRTPEEPWSYGLFIPHDPRAVGVVRATIRHVLRAARLDCIVGTAELLVSELVTNAYRNTTTDAYVSMDWEPTPPDFRVTVWDSGCGLPQQVVANAEDESGRGLTLVESCSDTWGVRDYTDKDTGVTGKAVWFTLTPPPPVMGQAQ
>NC_015957.1|WP_014054676.1|1280246_1281137_+|helix-turn-helix-transcriptional-regulator
MGLRADPTYRQRRFGIEVRRLREAAGLTVGEAAQVVGMRQPHFSNVEAGRTGLSAERLQKLTEALGGTYTYPVDALLALGQEPGNGWWSDYRTTLGATHLDLAELETGAVALRNYELLFIPGLLQTFEYATAVHSSGFSPTVSEVRDAAVEFRMRRQKVLPGERSPRFHAIVHEAALRVLYGGRAVMRDQLLRLIEVSRLPNVTIQIVPIDNEGSAAFSHPFMVIEPGVVELGTVLVDQVGKAQFLDERQTLSEYGESFARLSELALPPVDAEAAPEARTAKDSLGLIQHILYPLL
>NC_015957.1|WP_014054677.1|1281149_1281350_+|DUF397-domain-containing-protein
MSSFAWRKSSFSTGDAPNCVELAADPTGTPHLRESDDPEVVIATTPAALRAFLRAAKAGEFDRIEG

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Crispr_ID: NC_015957_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015957_7

1767245-1767321

Orphan

Consensus_repeat	Method
CAGAGCCAAGCCCGGACCAGAGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015957_7

>merge|NC_015957|7|1767245-1767321|CRISPRCasFinder
CCGAACCGGACCCGGACCAGAGCCAAGCCCGGACCAGAGCCTGGCCCGGACCACAGAGCCAGACCCAGACCACAGAG

>NC_015957|7|7|1767245-1767321|CRISPRCasFinder
CCGAACCGGACCCGGACCAGAGCC	AAGCCCGGACCAGAGCCTGGCCCGGACCA
CAGAGCCAGACCCAGACCACAGAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_015957.1\|WP_014055106.1\|1765673_1765841_-\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_043235556.1\|1772924_1774775_+\|acetolactate-synthase-large-subunit	unknown	unknown	gnl\|CDD\|236098
NC_015957.1\|WP_014055113.1\|1775466_1776465_+\|ketol-acid-reductoisomerase	unknown	unknown	gnl\|CDD\|235491
NC_015957.1\|WP_014055114.1\|1776737_1778339_+\|phosphoglycerate-dehydrogenase	unknown	unknown	gnl\|CDD\|237436
NC_015957.1\|WP_014055109.1\|1768428_1769427_+\|2-hydroxyacid-dehydrogenase	unknown	unknown	gnl\|CDD\|240643
NC_015957.1\|WP_014055100.1\|1754358_1755852_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA	unknown	unknown	gnl\|CDD\|234572
NC_015957.1\|WP_014055103.1\|1757921_1759412_-\|M81-family-metallopeptidase	unknown	unknown	gnl\|CDD\|377823
NC_015957.1\|WP_014055102.1\|1756195_1757701_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB	unknown	unknown	gnl\|CDD\|235489
NC_015957.1\|WP_078505167.1\|1778528_1779284_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NC_015957.1\|WP_014055104.1\|1759540_1761805_+\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NC_015957.1\|WP_014055107.1\|1765985_1767161_-\|PQQ-dependent-sugar-dehydrogenase	unknown	unknown	gnl\|CDD\|369642
NC_015957.1\|WP_014055117.1\|1780884_1781454_-\|AhpC/TSA-family-protein	unknown	unknown	gnl\|CDD\|239268
NC_015957.1\|WP_014055108.1\|1767353_1768352_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381302
NC_015957.1\|WP_014055101.1\|1755940_1756180_+\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_043235549.1\|1761952_1762186_+\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014055099.1\|1754056_1754353_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC	unknown	unknown	gnl\|CDD\|178810
NC_015957.1\|WP_014055112.1\|1774809_1775334_+\|acetolactate-synthase-small-subunit	unknown	unknown	gnl\|CDD\|183365
NC_015957.1\|WP_043235551.1\|1762313_1765460_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|274846
NC_015957.1\|WP_078505163.1\|1769626_1772695_+\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|236645
NC_015957.1\|WP_014055116.1\|1779328_1780819_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794

Protein	Function_ID	Function_description	E-value
NC_015957.1\|WP_014055113.1\|1775466_1776465_+\|ketol-acid-reductoisomerase	gnl\|CDD\|235491	PRK05479, PRK05479, ketol-acid reductoisomerase; Provisional.	0
NC_015957.1\|WP_014055114.1\|1776737_1778339_+\|phosphoglycerate-dehydrogenase	gnl\|CDD\|237436	PRK13581, PRK13581, D-3-phosphoglycerate dehydrogenase; Provisional.	0
NC_015957.1\|WP_014055109.1\|1768428_1769427_+\|2-hydroxyacid-dehydrogenase	gnl\|CDD\|240643	cd12166, 2-Hacid_dh_7, Putative D-isomer specific 2-hydroxyacid dehydrogenases. 2-Hydroxyacid dehydrogenases catalyze the conversion of a wide variety of D-2-hydroxy acids to their corresponding keto acids. The general mechanism is (R)-lactate + acceptor to pyruvate + reduced acceptor. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric.	9.42897e-148
NC_015957.1\|WP_014055100.1\|1754358_1755852_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA	gnl\|CDD\|234572	PRK00012, gatA, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA.	0
NC_015957.1\|WP_014055103.1\|1757921_1759412_-\|M81-family-metallopeptidase	gnl\|CDD\|377823	pfam07364, DUF1485, Metallopeptidase family M81. This is a family of proteobacterial metallo-peptidases.	3.22991e-119
NC_015957.1\|WP_014055102.1\|1756195_1757701_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB	gnl\|CDD\|235489	PRK05477, gatB, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB.	0
NC_015957.1\|WP_078505167.1\|1778528_1779284_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	7.73307e-10
NC_015957.1\|WP_014055104.1\|1759540_1761805_+\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	5.8088e-89
NC_015957.1\|WP_014055107.1\|1765985_1767161_-\|PQQ-dependent-sugar-dehydrogenase	gnl\|CDD\|369642	pfam07995, GSDH, Glucose / Sorbosone dehydrogenase. Members of this family are glucose/sorbosone dehydrogenases that possess a beta-propeller fold.	7.48406e-93
NC_015957.1\|WP_014055117.1\|1780884_1781454_-\|AhpC/TSA-family-protein	gnl\|CDD\|239268	cd02970, PRX_like2, Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these proteins do not contain the other two residues of the catalytic triad of PRX. PRXs confer a protective antioxidant role in cells through their peroxidase activity in which hydrogen peroxide, peroxynitrate, and organic hydroperoxides are reduced and detoxified using reducing equivalents derived from either thioredoxin, glutathione, trypanothione and AhpF. TRXs alter the redox state of target proteins by catalyzing the reduction of their disulfide bonds via the CXXC motif using reducing equivalents derived from either NADPH or ferredoxins.	1.33968e-25
NC_015957.1\|WP_014055108.1\|1767353_1768352_-\|aldo/keto-reductase	gnl\|CDD\|381302	cd19076, AKR_AKR13A_13D, AKR13A and AKR13D families of aldo-keto reductase (AKR). Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.	2.58329e-132
NC_015957.1\|WP_043235556.1\|1772924_1774775_+\|acetolactate-synthase-large-subunit	gnl\|CDD\|236098	PRK07789, PRK07789, acetolactate synthase 1 catalytic subunit; Validated.	0
NC_015957.1\|WP_014055099.1\|1754056_1754353_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC	gnl\|CDD\|178810	PRK00034, gatC, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC.	7.61552e-37
NC_015957.1\|WP_014055112.1\|1774809_1775334_+\|acetolactate-synthase-small-subunit	gnl\|CDD\|183365	PRK11895, ilvH, acetolactate synthase 3 regulatory subunit; Reviewed.	1.88574e-90
NC_015957.1\|WP_043235551.1\|1762313_1765460_+\|AAA-family-ATPase	gnl\|CDD\|274846	TIGR03903, TOMM_kin_cyc, TOMM system kinase/cyclase fusion protein. This model represents proteins of 1350 in length, in multiple species of Burkholderia, in Acidovorax avenae subsp. citrulli AAC00-1 and Delftia acidovorans SPH-1, and in multiple copies in Sorangium cellulosum, in genomic neighborhoods that include a cyclodehydratase/docking scaffold fusion protein (TIGR03882) and a member of the thiazole/oxazole modified metabolite (TOMM) precursor family TIGR03795. It has a kinase domain in the N-terminal 300 amino acids, followed by a cyclase homology domain, followed by regions without named domain definitions. It is a probable bacteriocin-like metabolite biosynthesis protein. [Cellular processes, Toxin production and resistance].	1.36577e-36
NC_015957.1\|WP_078505163.1\|1769626_1772695_+\|EAL-domain-containing-protein	gnl\|CDD\|236645	PRK10060, PRK10060, cyclic di-GMP phosphodiesterase.	1.6117e-71
NC_015957.1\|WP_014055116.1\|1779328_1780819_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	9.90889e-68

>NC_015957.1|WP_014055107.1|1765985_1767161_-|PQQ-dependent-sugar-dehydrogenase
MRRPRVTSVLAAAAAVLLVAGCSSDGDSIISPGGRSSAPSKPGGGGSSSGEPSPTESAAPAKGSVKVVRTLTTKLDSPWGLAPLPGGDLLVSSRDTGKIFKVSADTGKKTEVGSVPGVSAAGEGGLLGLAVSSDFGADHMVYAYFTTDSDNRIVRMVYDDKRPAGDQLGAPDTIFKGIPKGTIHNGGRIAFGPDKMLYAGTGESGDRGLAQDMDSFGGKILRMTPDGEPAPRNPDAQSVVYTWGHRNVQGLAWDADKRLWASEFGQDTWDELNPIEPGKNYGWPEVEGKAGKKGFVDPIEQWKPKDASPSGIAFAKGSIWMAGLRGERLWRIPLKGDKPVAKPQSFLDGKYGRLRSVVAADDGGLWLTTSNTDGRGKPGKQDDRILRLEVR
>NC_015957.1|WP_014055106.1|1765673_1765841_-|hypothetical-protein
MFNLIEELFAPGRKHTEEERNRLEVTLDETGSSDPGKGPVDLDSGRVVIRPREEG
>NC_015957.1|WP_043235551.1|1762313_1765460_+|AAA-family-ATPase
MLEDVHTTSVSPVFVGRAQELAALEDALARATAGEPQVLLIGGEAGVGKTRLIDEFLASAVAAGAVAAVGGCVEIGADGLPFAPVSTVLRSLRRKLGTELDGAAAGQEGELARLLPELGETARASHDGDGRARLFELTVRLLERLAAERTLVVAIEDLHWADRSTRELLGYLFRSLLSARLLVVATYRSDDIHRRHPLRPFLAEVDRMREVRRIEVSRFTRGEVHAQLTGINGAEPERDLVDRIFKRSDGNAFFVEEIARSLNEGCSTGLSESLRDLLLVRVEALPEEAQGVVRILAEGGSSVEYELLRAVARLGEDELIDALRAAVGANILRPTSDDSGYRFRHALMREAVVDDLLPGERSRLNRRFAQALEAEPALVRADERAARLASYWYYAHDPAKALPAVLQASVEARRRYAHAEQLRLLERAMELWEDAPEEIREAQRPVDYAEVYPACGCEDQALRQLDLLAEVVVAAHMSGQRERALAVAKRALRALDGSGDDPLRAAWFWTQQSKLMEGLARGDGWAELSRAQELVRGLPPSPVHADVMAHVAGWTMTHRPGPEGLAAAERAVELARMVGAESTELNARLTLGYFTGDSGDIERGLAEMREVCRQAVALGDVSVLGRCYVNLASALEGVGRSVEAVETAEEGARILDRVGLVDSRAWLYGNLAESLFSLGRWDEAEAAARKTRRLALGTKPHGTAANRLAELALARGEWDTAERELAAAREHYGAHNTEPQYTLQVAGRVIELAAARGRILEVRAVLDQVVEAGFPPGLQRYAWPLLYTAAAAESAARGLPTAEPGRGEALARLRAAAKRVAQPVPVWRAYAAMLQAERERAEGRDRPDLWGEATDAFAALDRPYPLARARHRWAEALLTPGQGAPAQADREHAAELLVQAHAVAEWLGARPLREEIELLARRARLPLASAATRPALDAPLPRTPALPPAPGSQTSGSQAPGSPVPAAEPADPAEELGLTPRERDVLRLVAAGRSNRQIAEELFISPKTASVHVSNILAKLGVSGRGEAAAVAHRLRLVDGLTDGAAAR
>NC_015957.1|WP_043235549.1|1761952_1762186_+|hypothetical-protein
MDAFHETLVTRENTMLHHELHRIREAELLREAAAHRLVREAVEASGGRSAGRESGGRVRPVRRWRGHRSPRSYRTAA
>NC_015957.1|WP_014055104.1|1759540_1761805_+|MMPL-family-transporter
MAALARWCLRRRAIVIALWLAAFAGVAAAAAVTGSAYSNDYDIPGTDSSKATALLERRLPDRAGDSDTIVWHTKDGAGTVRAPGVERRMTAALRQVPDLPGVASVTGPYGTDDTSRISADQHTAYATVAFRKPAADLGEAEVRRVLDTVRSAASGVRGLEVEMGGVGAGLTERTGPAHLSEAIGVGVAAVVLFLAFGSLAATLLPIATALIGVGTAYAAIGLLGHALTIADFAPMLGMLIGLGVGIDYALFIVTRHRRGLRRGLSVEQAAQRAVVTSGRAVVFAGATVCLALLGMLVLRLSFLNGVAVAAALTVALTVAASLTLLPALLGLIGMRALSRRERSRLAERGPEATAAKGLCARWAVCVERRPKLLGAAAAALIALLALPTFSLHLGTSDQGNGPSASTTRRAYDLLADGFGPGFNGPLTLMGSIDGADDRMAFTQLPKVLRTIDGVASVSAADLDGGGDTGVITVVPKTAPQSRATSDLVGRLRAEVLPQAEEGSSLRVYVGGLTAGYDDFAAVIVSKLPLFVGVVVALGCVLLLLAFRSIGIPIKAAVMNVAAVASSFGVVVAIFQWGWGSELLGLGRAGPIEPFLPVIMVSVLFGLSMDYQVFLVSRMYEEWRRTRDNRTAVRVGLAETSRVINSAAVIMIAVFSAFVLSGDRIIAMFGIGLAAAVALDAFVLRTLLVPALMHLLGGANWWLPGRLERLLPKISIEAEGEGEGRAAGSVPGPVSLPGQSGSGAARAGTARSPVP
>NC_015957.1|WP_014055103.1|1757921_1759412_-|M81-family-metallopeptidase
MTPAASRGRRPRIGIGGMHIESSTFSPHRTAYDDFRVIRDTELLDRYAWTRPDGDLAGRAEWVPLLHAVALPGGPVERETYDRIKGELIERLRRAGPLDGLVYDIHGAMSVVGLEDAEGDLTEAVREAIGPGALISAAMDPHGNVSRRFAGRLDLVTAHRLAPHEDAWETRERAARKLVERLDCGRGRPHLAWVQIPVLLPGERTSTRLEPAKSLYGRLAAVESMDGVVDAAIWVGYAWADEPRCRAAVVVTGDDPVLAVEQTRSLAREYWDMRRDFAFVGPTGGADACIAEAVASSARPFLISDSGDNPTAGGAGDLAYMLGRLLASEDLATGRATALHPGITDPAAVAECFAAGPGATVRLRVGGGISQGTADHAEPCELTGEVVALRRDDPVGGDLAAVRHGGVTVVLVSRRKPFHTLADFGELDPRDHDLVVVKIGYLEPELHDLAADWRLALTPGGVDQDLARLGHRRLARPLYPFDDEGFEVPHLEPLLL
>NC_015957.1|WP_014055102.1|1756195_1757701_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB
MTVTELVSYEDALAAYDPVMGLEVHVELGTKTKMFCGCSTALGAEPNTQTCPTCLGMPGSLPVVNATGVESAIKIGLALNCEIAEWCRFARKNYFYPDMPKNFQTSQYDEPIAYNGYLDVDVDGEVFRVEIERAHMEEDTGKSTHVGGATGRIQGAQHSLLDYNRAGIPLIEIVTKPIVGAGEKAPEIAKAYVTELRELIKSLGVSEARMEMGQMRCDVNLSLRPRGVEKFGTRSETKNVNSLRSVERAVRFEVQRHAAVLDDGGTIIQETRHFHEEDGSTTSGRVKEEAEDYRYFPEPDLVPVAPTRAWVEELRGGLPELPRVYRNRLREEWGLSRHEMQSVLNAGAIDLITATIDEGAPADQARKWWMGELARRANEDGVELAALPITPSQVARVCALVKEGSLNDKLARQTIEGVLAGEGGPDEVVTERGLKVVSDEGALGTAVDEAIAANAAIADKIRGGKVAAAGALVGAVMKATRGQADAARVRELILEKLGVEG
>NC_015957.1|WP_014055101.1|1755940_1756180_+|hypothetical-protein
MSAIKKAKGFKKSRPGTYLSIAGSLFGAVSVAKQVKKARFENDKLQLADAVVSAAAIVTGVALLVRELKRMGDDDVLAD
>NC_015957.1|WP_014055100.1|1754358_1755852_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA
MTDLTRLTAAEIAARIASGEVTAVEVTEAHLARIEAVDEKVHAFLHVDREGALAQARAVDEKRERGEELGPLAGVPLALKDIFTTKGIPTTVGSKILEGWIPPYDATVTQRLRDADVIILGKTNMDEFAMGSSTENSAFGPTGNPWDLTRIPGGSGGGSSASLASFQAPLAIGTDTGGSIRQPAAVTGTVGVKPTYGGVSRYGMVAFSSSLDQGGPCARTVLDAALLHEVIAGHDPMDSTSIDEPVPAVVEAARNGSVRGMRIGVVKEFAGEGYQAGVMQRFNESVELLRELGAEIEEISCPSFDKALAAYYLIAPSECSSNLARFDAMRYGLRVGDDGTKSAEEVTALTRAEGFGAEVKRRVMLGTYALSSGYYDAYYGSAQKVRTLIKRDFEKAFERVDVLISPTTPTTAFPIGERADDPMAMYLADLCTIPTNLAGNAAMSLPCGLAPEDGLPVGLQIIAPAMADDRLYKVGAAVEAALADKWGHPLLEEAPSL
>NC_015957.1|WP_014055099.1|1754056_1754353_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC
MPGITREEVAHLARLARLELKAEELDHFAGQLDDIIGAVARVSEVADQDVPPTSHPLPLTNVMRADEVRPSLTPQQALACAPAQEQQRFKVPQILGEE
>NC_015957.1|WP_014055108.1|1767353_1768352_-|aldo/keto-reductase
MKRRRIGAAALEVGAIGLGCMPMSWAYTASQRSGETSVRAVHTALDSGTSLLDTADMYGPFTNELLMGRVLKERRADAFVSTKCGLLVGEQHIVANGRPGYVKRACDASLRRLQTDVIDLYQLHRADPEVPIEETWGAMAELVAAGKVRALGLCAVGARAQRRAGARMHDATVRQLERVQQVFPVSCVQAELSVWSPDALEALVPWCASRGVGFLAAMPLGNGFLSGTLTPGQGFEPDDMRARHPRFTAEMMAANQPIVAGLRRVAQRHGDEVTPAQVALAWLLAQGPHVVPVPGTKRERWAAENCAAADVPLSHEDLAEIAELPPARGSWD
>NC_015957.1|WP_014055109.1|1768428_1769427_+|2-hydroxyacid-dehydrogenase
MSADHSDTFRQHDATQGSSEARDLVWLPIPPEEIDGLPDTLEYAHWDGGPDFPTDPARCAFYCVPYMKPPQVCTRPLSAMTNLRVVQTLTAGIDHIKPALADLAPGVRLCNARGVHDASTAELALTLILASLRGIPDFVRGQDAEEWRSGFRPALADKSVLIVGYGAIGSAIEDRLVPFECERVARVARSPRTTERGPVHPIDQLPQLLPEADVVVLVTPLTEATRGLAGSEFLSRMKDGALLVNVSRGGVVDTKALLTEVESGRLRAALDVTDPEPLPAGHPLWHAPGVLISPHVGGPTSAFLPRAKRLLRDQLNRFARGESLAHLVATTG
>NC_015957.1|WP_078505163.1|1769626_1772695_+|EAL-domain-containing-protein
MDRQPDAAQASTATLPRSRADLQLDEARGDTTPGVPAAPVVRHTVDGSPVSAMGAVLARPSVSGGGAGLLPQVVLALVCGGYAAGAVLGWGSSQLALVMGDFGLSAAALAAAVSCLWHGRRHAGRLRPAWLLFAASSAMAALGNGVWGWYEVVLGHPVPTPSAADFCFLLFAPPAIVGMLVLAKRPTSRARWICLGLDAWLIAGSLVTLSWSLALAHTGQFGGDGASVARGALALAYPLLDIVLVSMVIVLHFRRSTGNRSAVNTAIAAFALTVLCDALFTSPLLREHYRSGQILDAGWFAGSALLAYAPWVARREAAQDPPSARRTPQQSVPIAGSLAALAPYLAAAVCTLGVLFNVMDGRPIDGVVLSTACAVVLALVVRQAIMLMDNIRLTQELAEKENHFRSLVQSSSDVIMIAAPTGVLRYVSPAATGVYGRDADEMVGSELASLIHPEDLGSVVHEVRRFLAAAPGEEPTTRIECRFRSGSGDWLNVESTINRHHGGLIFNSRDVTERVRLQAQLQHNAEHDPLTDLPNRALFTRRVRHAVGGRRRTDAGTAVFFIDLDGFKAVNDTVGHHAGDELLVQAARRLQESVRSGSGDCAARLGGDEFATLIIGDGDGAGDAGAREQRIMEIADRLRVRLSQPYRVEGGTEVRVAASIGVAFAEPGTSPGALMRNADLAMYRAKAAGKNRVELYAPQMQAEVARRAEVATRLRAALHDGEFVLLHQPVVELTSGRITAVAAQARWRSAQGILFTPAEFLRVADNGRGGGEDTARTAELSRWMLEAAVEQAAQRRRDGHPVPVCVRLPASRLVDKSLPPKAVETLLARHGLPSGALILELTDSDPRVPLDELEHRLGALRRLGVRIALDGFGSGYAAIRALRRLPIDVLKLDPGLVEGVVESSRLHKITAGLLRIAGDLGMQSIAEGVELPEQIVTLRGMGCTHAQGAAFSGPLDEHRLRRALLRGGYPVPRSEPPLLVGGALPIRYGGHTGHGGSHGPRRTEPHTHPPTRSNTETPVPPT
>NC_015957.1|WP_043235556.1|1772924_1774775_+|acetolactate-synthase-large-subunit
MTEQAPGSHHPQPRPRSGGPQSAPVEHVTGAQSLIRSLEEVGADTVFGIPGGTILPAYDPMMDSSKVRHVLVRHEQGAGHAATGYAQATGKVGVCMATSGPGATNLVTPIGDAHMDSVPIVAITGQVASKAIGTDAFQEADICGITMPITKHNFLVTKAEDIPRTIAEAFHIASTGRPGPVLVDIPKDVLQTQTTFSWPPQIDLPGYRPVTKPHAKQIREAARLITQAERPVLYVGGGVIKAGATAELKVLAELTGAPVTTTLMALGSFPDSHHLHLGMPGMHGTVAAVTALQKADLIVALGARFDDRVTGKLDSFAPYAKIVHADIDPAEIGKNRVADVPIVGDAREVTADLVVAVQAEHDAGRAGDYSGWWEDLNRWRETYPLGYDQPADGSLSPQQVIQRIGQLAPEGTIFAAGVGQHQMWAAHFIDYDIPATWLNSGGAGTMGYAVPAAMGAKAGAEGRTVWAIDGDGCFQMTNQELVTCALNNIPIKVAIINNGALGMVRQWQTLFYNQRYSNTVLHSGPDTPAQQNAGTRVPDFVKLSEAMGCVGLRCEDPADLDAVIEKANAINDRPVVVDFIVHEDAMVWPMVAAGTSNDEILAARDTRPDFGDGADD
>NC_015957.1|WP_014055112.1|1774809_1775334_+|acetolactate-synthase-small-subunit
MSKHTLSVLVENTPGILARIAALFSRRGFNIDSLAVGVTEHPDISRITIVVNVEELPLEQVTKQLNKLVNVLKIVELEDGQAIQRELVLVKVRADNETRSQIVEIVQLFRAKTVDVSPEAVTIEATGGSDKLEAMLKMLEPYGIKELVQSGTIAIGRGARSITDRSLRALDRSA
>NC_015957.1|WP_014055113.1|1775466_1776465_+|ketol-acid-reductoisomerase
MAELFYDDDADLSIIQGRKVAILGYGSQGHAHALSLRDSGVDVRVGLHEGSKSKAKAEEQGLRVVTPAEASAEADVIMILVPDPIQAKVYEESVKDNLKDGDALFFGHGLNIRFDFIKPPAHVDVCMVAPKGPGHLVRRQYEEGRGVPCIAAVEQDATGNGFELALSYAKGIGGTRAGVIKTTFTEETETDLFGEQAVLCGGTSALVKAGFETLVEAGYQPEIAYFECLHELKLIVDLMYEGGLEKMRWSISETAEWGDYVSGPRIINDSTKAEMKKLLGEIQDGTFAKNWMAEYNAGLPKYNELKKADENHLLETTGKELRKLMSWVDEEA
>NC_015957.1|WP_014055114.1|1776737_1778339_+|phosphoglycerate-dehydrogenase
MSTASTGKPVVLIAEELSPATVEALGPDFEIRHCNGADRAELLPAIAGVDAILVRSATKVDAEAIALAKKLKVVARAGVGLDNVDVSTATKAGVMVVNAPTSNIVTAAELACGLLVATARNIPQASAALKNGEWKRSKYTGVELSEKTLGVVGLGRIGVLVAQRMSAFGMKVVAYDPYVQPARAAQMGVKLLSLDELLEVSDFISVHLPKTPETVGLIGDEALHKVKPELRIVNAARGGIVDEVALAAALKEGRVAGAGLDVFSQEPCTESPLFEFDNVVVTPHLGASTGEAQEKAGIAVARSVRLALAGELVPDAVNVQGGVIAEDVRPGLPLAEKLGRIFTALAGEVAVRLDVEVYGEITQHDVKVLELSALKGVFEDIVDETVSYVNAPLFAQERGVEVRLTTSSESSEHRNVVTVRGTLSDGEEVSISGTLAGHKHQQKIVAVGEYDVDLALADHMAFLRYTDRPGVVGTLGRILGEAGINIAGMQVSRAAAGGAALVALTVDDTIPQPVLTEIAEEIGASSARSVNLV
>NC_015957.1|WP_078505167.1|1778528_1779284_+|TetR/AcrR-family-transcriptional-regulator
MRCQESPVSADTDADALADVPPMRADARRNREQILRAAREVFADQGPDAPLDEIARRAGVGIATLYRRFPHRDDLHRGVAIEVLSALVEAGSRAAAEEDDARLALRRFMHAALDLKIGSVMPALLGRFTVDEILDGVPGDVVDPVDALLLSAQAQGLIRLDVVFGDITMMIMRLSRPLPGGGRFAADDALAHRQLDIYIDGLRPAGSPRPTTPLGGPAVDAAAFKRLRQQVIDDARAARSEARAEDTDDSD
>NC_015957.1|WP_014055116.1|1779328_1780819_+|MFS-transporter
MSQPSKTPPEANPRRWLALVFIGLAQLMIVLDITIVNIALPSAQKDLGISDGDRQWVITAYTLAFGSLLLLGGRIADYTGRKRTFLIGLLGFAGASALGGAASGFEMLLAARALQGAFAALLAPSALSLLAVNFTEPRERAKAFGIFGAIAAGGGAIGLVVGGLLTEYLDWRWCLYVNVPIAVIAAVSWSVLPTDARAEGRARFDIPGVLLAVCGLVAVVYGCSEAESEGWDSRLVTGLLILGAVLLIAFVLVERSVARPLLPPRVVADRSRGSAYLAVGLSVVGMFAMFLFLTYYMQLVKGYSALLTGVAFLPMTGAVLVGAGGVASRLIPRVPPRLLVAPGLLIAATGVALLVPLDVDSSYAAGVLPAELLVGFGMGLVMAPSMNYATHGVGEGDAGVASATVNTAQQIGGSIGTAMLNTIATSATSDYMASHAGRMTPRTAKAGLVEGFSHAFVVSSSILVGAAVVIALLMNTPRPVQEPSAEGATPLPAHMG
>NC_015957.1|WP_014055117.1|1780884_1781454_-|AhpC/TSA-family-protein
MEPGSVVAARTLTPVTGPDVAVPDPGRLIHLQFRRFAGCPVCNLHLRSIVRRHQELEAAGVREVVVFHSPAEELRKHTDELPFAVVADPGKRLYREFGVEQAPRALLSPRAWGPIARALLTGAWAVVRGREKLPAPSQPGGRLGLPADFLIGGDGRVIAAKHGEHAYDQWSVDELLALAARAPRPDPTP

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Crispr_ID: NC_015957_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015957_8

2495841-2496068

Orphan

Consensus_repeat	Method
CGGCGTCGCTCGGCTCGG	CRT

4 spacers

The CRISPR arrays of NC_015957_8

>merge|NC_015957|8|2495841-2496068|CRT
CGGCGTCGCTCGGCTCGGTGCCGTCCTGCCCTGCGCGGTCTTGCTCGGCGTCGCTCGGCTTGGCGCGGTCTTGCTCGGTGTCGCTCGGCTCGGTGTCGCTCGGCTTGGCGCAGTCTTGCCCGGCGCCGCTCGGCTTGGCGCAGTCTTGCTCGGTGTCGCTCGGATTGGCGTCGCTCGGCTCGGTGCCGCCCTGCCCGGCGCCCCCCTGCCCGGCGTCGCTCGGCTCGG

>NC_015957|8|1|2495841-2496068|CRT
CGGCGTCGCTCGGCTCGG	TGCCGTCCTGCCCTGCGCGGTCTTGCTCGGCGTCGCTCGGCTTGGCGCGGTCTTGCT
CGGTGTCGCTCGGCTCGG	TGTCGCTCGGCTTGGCGCAGTCTTGCC
CGGCGCCGCTCGGCTTGG	CGCAGTCTTGCTCGGTGTCGCTCGGAT
TGGCGTCGCTCGGCTCGG	TGCCGCCCTGCCCGGCGCCCCCCTGCC
CGGCGTCGCTCGGCTCGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_015957.1\|WP_014055713.1\|2497225_2499436_-\|trypsin-like-peptidase-domain-containing-protein	unknown	unknown	gnl\|CDD\|379142
NC_015957.1\|WP_014055701.1\|2479107_2479950_+\|apolipoprotein-acyltransferase	unknown	unknown	gnl\|CDD\|143592
NC_015957.1\|WP_078505212.1\|2504362_2505664_+\|glycerate-kinase	unknown	unknown	gnl\|CDD\|376844
NC_015957.1\|WP_106685864.1\|2499439_2499856_-\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014055712.1\|2496135_2497161_-\|AAA-domain-containing-protein	unknown	unknown	gnl\|CDD\|223786
NC_015957.1\|WP_014055706.1\|2485210_2486701_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NC_015957.1\|WP_014055704.1\|2482752_2483754_+\|TIGR03842-family-LLM-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|163554
NC_015957.1\|WP_014055710.1\|2490279_2491239_-\|hydroxymethylbilane-synthase	unknown	unknown	gnl\|CDD\|272963
NC_015957.1\|WP_014055705.1\|2484053_2485091_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|366359
NC_015957.1\|WP_078505705.1\|2506621_2507476_-\|CDP-diacylglycerol--serine-O-phosphatidyltransferase	unknown	unknown	gnl\|CDD\|224104
NC_015957.1\|WP_014055716.1\|2501702_2502206_+\|methylated-DNA--[protein]-cysteine-S-methyltransferase	unknown	unknown	gnl\|CDD\|223427
NC_015957.1\|WP_014055700.1\|2476966_2478814_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NC_015957.1\|WP_014055715.1\|2500018_2501494_+\|DNA-3-methyladenine-glycosylase-2-family-protein	unknown	unknown	gnl\|CDD\|225080
NC_015957.1\|WP_043235738.1\|2488832_2490254_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224154
NC_015957.1\|WP_043238462.1\|2480042_2481338_+\|aspartate-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|99735
NC_015957.1\|WP_043238473.1\|2502226_2502988_-\|NAD-dependent-deacetylase	unknown	unknown	gnl\|CDD\|238701
NC_015957.1\|WP_043235736.1\|2481334_2482738_+\|dihydropyrimidinase	unknown	unknown	gnl\|CDD\|236240
NC_015957.1\|WP_014055708.1\|2487968_2488796_+\|inositol-monophosphatase	unknown	unknown	gnl\|CDD\|334090
NC_015957.1\|WP_014055718.1\|2503204_2504281_-\|ADP-ribosylglycohydrolase-family-protein	unknown	unknown	gnl\|CDD\|377122
NC_015957.1\|WP_014055721.1\|2507468_2508125_-\|phosphatidylserine-decarboxylase	unknown	unknown	gnl\|CDD\|235400

Protein	Function_ID	Function_description	E-value
NC_015957.1\|WP_014055713.1\|2497225_2499436_-\|trypsin-like-peptidase-domain-containing-protein	gnl\|CDD\|379142	pfam13365, Trypsin_2, Trypsin-like peptidase domain. This family includes trypsin-like peptidase domains.	7.99971e-07
NC_015957.1\|WP_014055701.1\|2479107_2479950_+\|apolipoprotein-acyltransferase	gnl\|CDD\|143592	cd07568, ML_beta-AS_like, mammalian-like beta-alanine synthase (beta-AS) and similar proteins (class 5 nitrilases). This family includes mammalian-like beta-AS (EC 3.5.1.6, also known as beta-ureidopropionase or N-carbamoyl-beta-alanine amidohydrolase). This enzyme catalyzes the third and final step in the catabolic pyrimidine catabolic pathway responsible for the degradation of uracil and thymine, the hydrolysis of N-carbamyl-beta-alanine and N-carbamyl-beta-aminoisobutyrate to the beta-amino acids, beta-alanine and beta-aminoisobutyrate respectively. This family belongs to a larger nitrilase superfamily comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), this subgroup corresponds to class 5. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer. Beta-ASs from this subgroup are found in various oligomeric states, dimer (human), hexamer (calf liver), decamer (Arabidopsis and Zea mays), and in the case of Drosophila melanogaster beta-AS, as a homooctamer assembled as a left-handed helical turn, with the possibility of higher order oligomers formed by adding dimers at either end. Rat beta-AS changes its oligomeric state (hexamer, trimer, dodecamer) in response to allosteric effectors. Eukaryotic Saccharomyces kluyveri beta-AS belongs to a different superfamily.	1.59216e-154
NC_015957.1\|WP_078505705.1\|2506621_2507476_-\|CDP-diacylglycerol--serine-O-phosphatidyltransferase	gnl\|CDD\|224104	COG1183, PssA, Phosphatidylserine synthase [Lipid metabolism].	3.06062e-32
NC_015957.1\|WP_078505212.1\|2504362_2505664_+\|glycerate-kinase	gnl\|CDD\|376844	pfam02595, Gly_kinase, Glycerate kinase family. This is family of Glycerate kinases.	6.87573e-163
NC_015957.1\|WP_014055712.1\|2496135_2497161_-\|AAA-domain-containing-protein	gnl\|CDD\|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	1.07746e-14
NC_015957.1\|WP_014055706.1\|2485210_2486701_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	6.41553e-79
NC_015957.1\|WP_014055704.1\|2482752_2483754_+\|TIGR03842-family-LLM-class-F420-dependent-oxidoreductase	gnl\|CDD\|163554	TIGR03842, F420_CPS_4043, F420-dependent oxidoreductase, CPS_4043 family. This model represents a family of putative F420-dependent oxidoreductases, fairly closely related to 5,10-methylenetetrahydromethanopterin reductase (mer, TIGR03555), both within the bacterial luciferase-like monoxygenase (LLM) family. A fairly deep split (to about 40 % sequence identity) in the present family separates a strictly Actinobacterial clade from an alpha/beta/gamma-proteobacterial clade, in which the member is often the only apparent F420-dependent LLM family member. The specific function, and whether Actinobacterial and Proteobacterial clades differ in function, are unknown. [Unknown function, Enzymes of unknown specificity].	0
NC_015957.1\|WP_014055710.1\|2490279_2491239_-\|hydroxymethylbilane-synthase	gnl\|CDD\|272963	TIGR00212, Porphobilinogen_deaminase, hydroxymethylbilane synthase. Alternate name hydroxymethylbilane synthase Biosynthesis of cofactors, prosthetic groups, and carriers: Heme and porphyrin [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin].	8.1515e-119
NC_015957.1\|WP_014055705.1\|2484053_2485091_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|366359	pfam00891, Methyltransf_2, O-methyltransferase. This family includes a range of O-methyltransferases. These enzymes utilize S-adenosyl methionine.	3.62801e-22
NC_015957.1\|WP_014055716.1\|2501702_2502206_+\|methylated-DNA--[protein]-cysteine-S-methyltransferase	gnl\|CDD\|223427	COG0350, Ada, Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair].	7.85951e-58
NC_015957.1\|WP_014055700.1\|2476966_2478814_+\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	4.61536e-12
NC_015957.1\|WP_014055715.1\|2500018_2501494_+\|DNA-3-methyladenine-glycosylase-2-family-protein	gnl\|CDD\|225080	COG2169, Ada, Adenosine deaminase [Nucleotide transport and metabolism].	1.1297e-58
NC_015957.1\|WP_043235738.1\|2488832_2490254_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224154	COG1233, COG1233, Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism].	9.12644e-84
NC_015957.1\|WP_043238462.1\|2480042_2481338_+\|aspartate-aminotransferase-family-protein	gnl\|CDD\|99735	cd00610, OAT_like, Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase, alanine-glyoxylate aminotransferase, dialkylglycine decarboxylase, 4-aminobutyrate aminotransferase, beta-alanine-pyruvate aminotransferase, adenosylmethionine-8-amino-7-oxononanoate aminotransferase, and glutamate-1-semialdehyde 2,1-aminomutase. All the enzymes belonging to this family act on basic amino acids and their derivatives are involved in transamination or decarboxylation.	1.59409e-134
NC_015957.1\|WP_043238473.1\|2502226_2502988_-\|NAD-dependent-deacetylase	gnl\|CDD\|238701	cd01410, SIRT7, SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.	3.36735e-86
NC_015957.1\|WP_043235736.1\|2481334_2482738_+\|dihydropyrimidinase	gnl\|CDD\|236240	PRK08323, PRK08323, phenylhydantoinase; Validated.	0
NC_015957.1\|WP_014055708.1\|2487968_2488796_+\|inositol-monophosphatase	gnl\|CDD\|334090	pfam00459, Inositol_P, Inositol monophosphatase family.	1.72577e-52
NC_015957.1\|WP_014055718.1\|2503204_2504281_-\|ADP-ribosylglycohydrolase-family-protein	gnl\|CDD\|377122	pfam03747, ADP_ribosyl_GH, ADP-ribosylglycohydrolase. This family includes enzymes that ADP-ribosylations, for example ADP-ribosylarginine hydrolase EC:3.2.2.19 cleaves ADP-ribose-L-arginine. The family also includes dinitrogenase reductase activating glycohydrolase. Most surprisingly the family also includes jellyfish crystallins, these proteins appear to have lost the presumed active site residues.	1.35928e-38
NC_015957.1\|WP_014055721.1\|2507468_2508125_-\|phosphatidylserine-decarboxylase	gnl\|CDD\|235400	PRK05305, PRK05305, phosphatidylserine decarboxylase family protein.	2.45568e-91

>NC_015957.1|WP_014055710.1|2490279_2491239_-|hydroxymethylbilane-synthase
MSSVSDSGHGSAELIRIVSRSSPMALAQVERVRAELAALRPGIRTEVVPVTTSGDRWMGDLSKLGGKGAFTKEVDAALLAGEADLAVHCIKDVPADRPLPAGTVFAAYLKRDDIRDAVIHPEGLTLDEMPAGTRIGTSSVRRVAQLAITHPELECVPMRGNANRRLEKLEAGECDALMLAVSGLERIGRTDRISEILPVDTMCPPIGAGVLGLQCREDDTETIEAVAGLGDADVWKEITAERMLLHVLQGHCNSPIAGYAKAERDGRLSLRARVFSPDGKRVLDAHEWAGPLDPATLGTSVAVALLRQGAREVIDTIPH
>NC_015957.1|WP_043235738.1|2488832_2490254_+|NAD(P)/FAD-dependent-oxidoreductase
MPSMLDAVVVGAGPNGLTAAVELARRGCAVEIFEAADTIGGGSRTEELTLPGFRHDPCSAVHPLAIGSPAFDRMPLARHGLEWLHPELPLAHPFPDGTAAVLARSVGETARSLGPRDAGTYRRLIAPYLGKWATLAPDMLRTPWDGVPRDPITWARFGLHALQPVSLLAGPLRFRDEKARALFTGLAGHAIAPTSALVTGGLALIFAVAAHEVGWPIPRGGSQSIVDALGAYLRENGGTIHVSTEVKRLDELPPARAYIFDTSPRALARIAGLGNAYRHYRYGAGAFKLDYALSGPVPWTAPEARRAGTVHVGPTSGEIGAALRAAVDGRDPSVPFLITSSPTLLDPSRAPEGKHTFWAYGHVPSGWKGDATEVIERQLERFAPGFRDLVLARAVAGPPELAARNANYIDGDIACGAFEGIQAAIRPKLARVPYATAHPAVFLCSSATPPGPGVHGMSGHHAARAVWRRLRAR
>NC_015957.1|WP_014055708.1|2487968_2488796_+|inositol-monophosphatase
MIDEFLAGDLGAVEQAIRTAVADEVMPRYRQLAAHEIVEKKGPHDLVTTADRQAEEHLTGALTKLLPGSVVVGEEAVHADPAVLTALGGDAPVWIVDPVDGTRQFVHGDPGFATLVTLAHGEELLASWTYAPVFDQMAIARRGGGALLNGEPIHCGSPEPGAVLHVAVSHYDFTTDEEKRALSGLQVPGVEVRPCGSAGLEYLNVARGLLDAVAFTWENAWDHAAGLLLVGEAGGAHATLAGEPFRITGGNALPFTAARDEATVAHILGLLAAAG
>NC_015957.1|WP_014055706.1|2485210_2486701_+|MFS-transporter
MAGATSQATPGDADGEGDGPPPHHRHKWLILGICCISLFMVGLDTTIVNLALPSIQDDLDASPSGLQWTVDSYTVVLASLLMLSGSMADRFGRRRTFQTGLLLFSLGSLLCGLATDTGSLIAFRMVQAMGGAMLNPVAVSIIANTFTDLRERARAIGLWGAVAGVSIALGPVVGGALVDSTGWQAVFWVNLPVAALALVLTALFVPESKAPRPRRLDPVGQLLVIVLLATLTFGIIEGPVRGWGSAQIIGCFTVAAVAAATLIRYELRRAEPLLDVRFFRSPSFSGAIASAVCGFAALAGFLFLNALYLQDVRDFSPLHTGLLTLPMAAMTLISSPLAGRIVGARGPRIPMVIAGAGTAGCGLLLTRVGADTPIWYLVIAYVAFGIGFGMLDAPLTYSAVSGMPRSQAGVAAAVTSTGRQVGAALGVAVLGSVSTARVHGPFASGFPEASHLGWAIMAGCGLAIVTLGLLTTGPRARGPADPSPNPAPDRPAQRVR
>NC_015957.1|WP_014055705.1|2484053_2485091_+|methyltransferase-domain-containing-protein
MTQTEVPIEVELRGLYKAHYRFQFLSAGFQLGLFALAEKEPGLAVREIAARLDLKEQPTRILLLGCTVFGLLRKDGEGYHTTPLSKPLTANFDESPASNIPWEQHGIYRAMAWFCESLKEDTNIGLRREIPGTASTLYGRLAENPELESTFHTMMSSVSRLVGAELGERLELSGCGHLLDIGGGTAINAASLAARWPDLRITIADLPSVTTAANEKIEKLGLADRVRAVSLDALHDEFPAGCDGVLFAHFLEIWSPERIQELLAKAARALPPGGGIYVVTPRQDDDGTGPERAAMLSAYFHTIASGEGMVYTGAEYEQWFRAVGFEPTGRLPLGADTVVITGRKA
>NC_015957.1|WP_014055704.1|2482752_2483754_+|TIGR03842-family-LLM-class-F420-dependent-oxidoreductase
MDFGLVLQTDPPASAVVELMRRAERNGFGYGWTFDSAVLWQEPFVIYSQILARTERLIVGPMVTNPGTRTWEVTASTFATLNEMYGNRTVCGIGRGDSALRVAGRKPNTLARLGEAIDAIRDLAEGREAVVDGSPMRIPWIEDSRLPVWMAAYGPKALALAGQKADGFILQLADPFLTEWMVKAVRTAAAEAGRDPDAVTICVAAPAYVGDDLAYAREQCRWFGGMVGNHVADLISRYGEHSGAVPESLTAYIKERQGYDYAHHGRSGNPDTAFVPDEIVDRFCLLGPAEAHIEKLERLRALGVDQFAVYAMHDAKERTLDAYGERVIPALTG
>NC_015957.1|WP_043235736.1|2481334_2482738_+|dihydropyrimidinase
MMSRTVIRGGLVVTAAEETLADVLIEDGKVAALASSGSAYAEGWTADRTIDATGKYVIPGGVDGHTHMEMPFGGTYAADTFETGTRAAAWGGTTTIVDFAIQTVGHALREGLDAWDLKARGNCAIDYGFHMILSDVNESALKEMDLLVGEGVTSFKLFMAYPGVFYSDDGQILRAMQRASANAGLIMMHAENGIAIDVLVEQALAEGRTDPRYHGEVRKALLESEATHRAIQLARVAGAPLYVVHVSAQEALAELTQARDLGLPVFGETCPQYLFLSTDNLAEPDFEGAKYVCSTPLRPVEHQAALWRGLRTNDLQVVSTDHCPFCFTGQKELGRGDFSKIPNGMPGVEHRMDLLHQAVVDGHISRRRWIEIACATPARMFGLYPRKGTIAPGTDADIVVYDPAAQQTLSVETHHMDVDYSAYEGKRITGQVETVLSRGVPVIDRREYTGRAGHGQFLVRDTCQYLG
>NC_015957.1|WP_043238462.1|2480042_2481338_+|aspartate-aminotransferase-family-protein
MHTRHQAVLPDWLAVYYQRPIEITHGEGRHVWDAEGNRYLDFFGGILTTMTAHALPEVTKAISEQAGRILHTSTLYLDRPMVDLAERVATLSGIPDARVFFTTSGTEANDTALLLATTYRRSNQILAMRNSYHGRSFSAVGITGNRGWSPTSLSPLQTLYVHGGVRTRGPFAGLSDGEFIKACVADLEDVLGQAHGNVAALIAEPVQGVGGFTSPPDGLFAAFREVLDRHGILWITDEVQTGWGRTGDHFWGWQAHDRSGPPDILTFAKGIGNGMSIGGVVARAEVMNCLGANSISTFGGSPITMAAGLANLTHLVEHDLQGNARRVGGLLIERLRAACAGLDTVREVRGRGLMIGIELVEPGTGAPYPEGASAVLEAAREGGLLIGKGGGHNSSVLRIAPPLSLTVAEAEEGAEILEAALKTTRSGRSVS
>NC_015957.1|WP_014055701.1|2479107_2479950_+|apolipoprotein-acyltransferase
MANLVRAALVQATWTGDTESMIAKHEEYARQAAAQGAKVIGFQEVFNAPYFCQVQEAEHYRWAEPVPDGPTVQRMRELARETGMVIVVPVFELEQSGFYYNTAAVIDADGSYLGKYRKHHIPQVKGFWEKYYFKPGNVGWPVFDTAVGKVGVYICYDRHFPEGWRALGLAGAQLVYNPSATSRGLSAYLWQLEQPAAAVANEYFIAAINRVGTEEYGDNDFYGTSYFVDPRGQFVGDAASDKEEELIIRDLDFGLIDEVRQQWAFYRDRRPDAYEGLVKP
>NC_015957.1|WP_014055700.1|2476966_2478814_+|hypothetical-protein
MASGQLPAEVEEFASYLRALTRRLDAGTGWYGVFALRDPEGLRACLDGLEVPPWDVVQSLLQDLSTQRGAGPAQEAAARAATLYRASVAAHDAGPGSREALQDRLDGMLREQRNAARRERDLQAAVSAAEGAADRERLGAELAWAHDDWRRATARTEELHARLTALTPRPSQPPPPQPGPPTPAAPPPAGPTPTAQAPAPRPTAPTGPTPTAPAPAPRPLAPTTGPTPPDTSASAVGSGADASAEPPAQGLRPAPPASTPAPWPAAPAAGPTPPGTSVGAPAPAPAPAAGSARPVPRGAWFAGVEEVGAAPGPSVSEAAVEATPPDTPALGVASGADVAFEVPVQGREPVPPAPASASPRLRGARFAGAGGGGTAALLPSSPAPPPAESGTELPATPRGARFAGAYDGEGGGKRRKRDKAADDGRRLAREAAERAAARRAAQEAVARVGRLRVAGRSGEAHAVLCEAAAWPAPRLPVLAEELERAGLGADVSTLLWEMACLPPGRLAAAAEALVAADREADGERLLRQSVSRPVPEVAHTAQALLAAGVPRRAAFLLEALVRARTPEEAARAAAEDPATLVPLLLDAAAGVSSSSYHDLAHALRAAGLPGVPGLA
>NC_015957.1|WP_014055712.1|2496135_2497161_-|AAA-domain-containing-protein
MSAEADRKGGSPMNPRDRHDWRLFRGDGVPRRVEMPPAPPWRRFDGGDQEAPGGEQAPSASGPAGPAPYLISPEHADVVNAALHLRRPLLVTGSPGTGKSSLAQAVAHEMGLGEVLRWPVNSRSTVQDALYRYDAIGRLRETALTRDRGEAEPDIGSFVRLGPLGTALVPNERPRVLLVDELDKGDVDLPNDLLTVFEEGEFEIPELARLPEDQSVVEVLTARAGERATVRRGRLVCEEFPVVVITSNGERDFPPAFLRRCVRLELPTPDEGRLRAIVTAHLGDDALEEVDQLLDAFLRRRAARELATDQLLNAVFLRAGGMDVTADGLLEAVLHRLGGAV
>NC_015957.1|WP_014055713.1|2497225_2499436_-|trypsin-like-peptidase-domain-containing-protein
MGWFHAHGSLSRPAVSILAKADGRPAGAGVLLPRRHLLTCAHVVNSALGKDRLAPDHPGPVAVPVRLHGPEHTVEAEAELAVWIPPRTDDGGLGAFEWNGDLAVLRLSAALPPAIEPPRWHPMAQRQLVRAWHGSGEPGVFADAEVSECDGRFGYFDGAERALDIEPAYSGGPLWSNEEGAVVGLVTAKLRIQGTLRRAWGIPWQRVARELHDAGAGHLLPRQPEEDVRDHPGYAELVSLLDGPLPRSEGWIRSCRTVARQCGLGHRADGVPSADEFAHLLLTRGRALPALVEAVRGTAGTAGTAADDLLAIGRRCGLPKLLSPGEHERLLVLLRALPTAAAAGVPGAVRAALPLAALPAALLTGGDGGHGGDGGHCDEGRNSTGPAGRFEALIAHLEGLHGDSSPIDDGVMAVPGLLRAVEFVAAGCCPADQRTPLRRWNAAVARRLGVHDAAMTERRLEAEQWAQSASRGSAPRVVAKLDLCGAPSGGTSATAREEPERYRLRLWCDDGDGLRQVSDDSERPRGAEEVAQEIFAAVGSLRRPDPSGPRPVIELIVDRDALEVPVDRWKAAGPGAVLPMRLGTPYPLVVNCPELRELNGGTMLDQWRERWVRLDAEEPVHIDDATAPDPEAVCGLVMERLTARVTIDVAAHRRTGVVQMCLAAGIPVVLWDRSGEAGSPAVRHAAGVSTRELPEAVRTYRTKTLQRPEEYSGRPVLAWADAGRALPRLDLADPTE
>NC_015957.1|WP_106685864.1|2499439_2499856_-|hypothetical-protein
MTEHREIPLANGTTVRLELAPVGDASLEDAYGGVGGVTPVGRGAQAAVTLANASLNVILQGLGSVLEDVHDAVRSTPHPPQEFTVQFGVQVGQDLKLGIVGANGNANLTLSATWRPSERPEPTVPPQPPQPSRPGPSA
>NC_015957.1|WP_014055715.1|2500018_2501494_+|DNA-3-methyladenine-glycosylase-2-family-protein
MHTDTDRCLRAAQAKDARFDGWFFVAVVTTGIYCRPSCPVVGPKAENMRFHPSAAAAQQAGFRACKRCRPDASPGSPQWNERADLVARAMRLIADGVVDRDGVPGLAARLGYSTRQVERQLLAELGAGPLALARAQRAQTARLLIETSALPMADIAFAAGFASVRAFNETVREVFALSPTELRQRATRGPRTSVPGALTLRLPFRAPLCPDNLFGHLAATAVPGVEEWRDGAYRRTLRLPYGPGVVTLSPRPDHIACQLSLADLRDLAGAISRCRRLLDLDADPTAVDDLLRTDLQLAPLVDKAPGRRVPRAVDADEFAVRAVLGQQVSTAAARTHAGRLVAAHGEPVEDPGGGLTHLFPSVQALAGLDPETLAMPRTRRATLTGLVGALAEGRVALGVGSDWDDARAALGTLPGLGPWTVEVIAMRALGDPDAFVPTDLGVRRAAAELGLPATPGALTRHSARWRPWRAYAVQHLWATDAAHAINRLPAA
>NC_015957.1|WP_014055716.1|2501702_2502206_+|methylated-DNA--[protein]-cysteine-S-methyltransferase
MHRTHTVVDSPYGPLTLVATGPQLSGLYMVEQRHRPPEETFGAPGGPDDAPFAETVRQLAAYFEGELTAFDLPLHLDGTPFQRRVWAELRRIPYGGTWSYGQLADHIGQPTASRAVGLANGKNPVGIIVPCHRVVGSSGSLTGYGGGLDRKRRLLEFEARQQLPGLF
>NC_015957.1|WP_043238473.1|2502226_2502988_-|NAD-dependent-deacetylase
MSSETTHRPLVAILSGAGISTDSGIPDYRGPQGLWRRDPEAEKLVTYEYYMTDPEIRRRSWQMRRDSETLRARPNGAHEAVTRLERSGVPVRVITQNVDGLHQIAGMPTRKVLELHGTARAVLCTHCEARSGMEEALERVAAGDPDPACRECGGILKSATVMFGESLDPEVLTEAVAVAQACEIFIAVGTSLQVQPAASLAGLAAEHGARLIIVNAEPTPYDELADEVVREPISTALPAVLDRVAAGGGGGGG
>NC_015957.1|WP_014055718.1|2503204_2504281_-|ADP-ribosylglycohydrolase-family-protein
MALSGSALADRIHGGWLGRIAGNMLGKPIEDGNHWTRDRIDRYLRRADALPLTGYLPALEPPPDPVEFALRPEWQSCVRGRIHGSCRDDDVDYSVLGLHLLETHGPGFTTEQVGEVWLLRLPYLQTFTAERAAYRNLTAGVRPPLSATLDNPYQEWIGALIRADVHGWVNPGDPHRAAAMARRDAVLSHTGNGVYGAMWAAALIAAAFTADGPRAAVASALDRIPPRCRLARTVRRAASLHDAGVAWADTLAQLERETAGLPWIHVVPNAAVLTAGLLYGAGDFTKTIALTVRGGLDTDSNGATAGSVAGVLCGAAAIPPQWTEPLEDRVRSAVFGFDGARISDLAARTHRLAVAAER
>NC_015957.1|WP_078505212.1|2504362_2505664_+|glycerate-kinase
MRGVTKVTDASTETSGATGASRAEAAADAETATETDTDTKPETKTWAEGQATRPKRVLIAADKFKGSLTAVEVAERVTAGLRRGAPHGGEGLRIAALPVADGGDGTVDAAVAAGFERREAQVTGPLGAPVTAAYALRGTTAVVEMAEASGLRHLPAGVFAPLTATTYGSGELLRAALDAGARTIVFGVGGSATTDGGAGMLSALGARFLREDGTPVAPGGGPLRDLATADLSGLDPRLADTETVLASDVDNPLTGPKGAAAVYGPQKGAGEDDVAALDAALAHYVRVLERAVGASAAEDALAPGAGAAGGIGFGALVGLGAAFRPGIEVMLDVLGFPAALEGTDLVITGEGSLDEQTLHGKAPAGVAAAARARGIEVVAVCGRLALAPVALGNAGIRRAYPLTDLEPDPARCIAEAGPLLERAAERLAADFLT
>NC_015957.1|WP_078505705.1|2506621_2507476_-|CDP-diacylglycerol--serine-O-phosphatidyltransferase
MIDPDTQAAWVPEAEVDAVDETDDMPLSTRLSIADTLTLGNATCGFLAVYFTTTGVLIPHLTGSEDGGMARHSAASAVMLMLLASVFDLFDGLVARKLRSSAMGAELDNLSDLISFGLAPAYFVLVWGMVSDDAYQRVSVVGAIVVLLAVVLRLARFSCVTLRDGVFQGMPSPFGALTVVSVVLLGLPFVPTLLAIIGVAWLMVSRVEYPKPRGRLAVAMLGWIVTSMALLAAWAFEAPGGELLLQSACALQVVMGAVIPLFATARRVNAFRDNRREARAAQLP
>NC_015957.1|WP_014055721.1|2507468_2508125_-|phosphatidylserine-decarboxylase
MPHSQSSAQRDSPVGVRLARGASPWLLPTVATAAVSLARARRSGRWAAVAVPATALAAGMLWFFRDPEREITHGRVISPADGVVQSIMPWKDGRTRVAIFMSPLNVHVNRAPLAGTVTSVEHIPGGFVPAFNKESENNERVVWHFDTELGDIEMVQIAGAVARRIVPYVPQGTKVEQGERIGLIRFGSRVDIYLPEGVDIAVEVGQATTAGVTRLDRD

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Crispr_ID: NC_015957_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015957_9

2874859-2874940

Orphan

Consensus_repeat	Method
GACCCGGGGCCGGGCCTGCCGTGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015957_9

>merge|NC_015957|9|2874859-2874940|CRISPRCasFinder
GACCCGGGGCCGGGCCTGCCGTGTCCTGTACGGAGGCGAGGGGCCCTGGGACGGCAGGGACCCGGGGCCGGGCCTGCCGTGT

>NC_015957|9|8|2874859-2874940|CRISPRCasFinder
GACCCGGGGCCGGGCCTGCCGTGT	CCTGTACGGAGGCGAGGGGCCCTGGGACGGCAGG
GACCCGGGGCCGGGCCTGCCGTGT

Protein	Signature genes	Signature genes Name	Protein_function
NC_015957.1\|WP_014056012.1\|2876110_2876524_-\|SsgA-family-sporulation/cell-division-regulator	unknown	unknown	gnl\|CDD\|377399
NC_015957.1\|WP_014056007.1\|2864965_2866435_-\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|143437
NC_015957.1\|WP_014056013.1\|2876752_2878249_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|237537
NC_015957.1\|WP_014056006.1\|2863421_2864969_-\|amino-acid-permease	unknown	unknown	gnl\|CDD\|132469
NC_015957.1\|WP_014056015.1\|2879764_2879905_+\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014056019.1\|2882450_2882648_+\|DUF397-domain-containing-protein	unknown	unknown	gnl\|CDD\|377231
NC_015957.1\|WP_014056020.1\|2882662_2882959_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225225
NC_015957.1\|WP_014056016.1\|2879901_2881080_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|275041
NC_015957.1\|WP_043235830.1\|2878400_2879579_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NC_015957.1\|WP_014056002.1\|2857863_2858829_-\|LLM-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274645
NC_015957.1\|WP_014056017.1\|2881418_2882267_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379262
NC_015957.1\|WP_043238597.1\|2856962_2857877_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NC_015957.1\|WP_014056018.1\|2882245_2882446_+\|DUF397-domain-containing-protein	unknown	unknown	gnl\|CDD\|377231
NC_015957.1\|WP_014056010.1\|2873532_2874195_+\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014056011.1\|2875155_2875836_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377552
NC_015957.1\|WP_014056000.1\|2855333_2856443_-\|dimethyl-sulfone-monooxygenase-SfnG	unknown	unknown	gnl\|CDD\|274923
NC_015957.1\|WP_014056003.1\|2858941_2860912_-\|hydrolase	unknown	unknown	gnl\|CDD\|238869
NC_015957.1\|WP_043235826.1\|2861033_2861828_+\|IclR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224332
NC_015957.1\|WP_014056005.1\|2861860_2863411_-\|FAD-binding-protein	unknown	unknown	gnl\|CDD\|235000
NC_015957.1\|WP_050993931.1\|2867694_2871063_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_015957.1\|WP_014056012.1\|2876110_2876524_-\|SsgA-family-sporulation/cell-division-regulator	gnl\|CDD\|377399	pfam04686, SsgA, Streptomyces sporulation and cell division protein, SsgA. The precise function of SsgA is unknown. It has been found to be essential for spore formation, and to stimulate cell division.	1.27201e-39
NC_015957.1\|WP_014056003.1\|2858941_2860912_-\|hydrolase	gnl\|CDD\|238869	cd01831, Endoglucanase_E_like, Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.	5.41314e-28
NC_015957.1\|WP_014056013.1\|2876752_2878249_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|237537	PRK13875, PRK13875, conjugal transfer protein TrbL; Provisional.	4.28187e-09
NC_015957.1\|WP_014056006.1\|2863421_2864969_-\|amino-acid-permease	gnl\|CDD\|132469	TIGR03428, ureacarb_perm, permease, urea carboxylase system. A number of bacteria obtain nitrogen by biotin- and ATP-dependent urea degradation system distinct from urease. The two characterized proteins of this system are the enzymes urea carboxylase and allophanate hydrolase, but other, uncharacterized proteins co-occur as genes encoded nearby in multiple organisms. This family includes predicted permeases of the amino acid permease family, likely to transport either urea or a compound from which urea is derived. It is found so far only Actinobacteria, whereas a number of other species with the urea carboxylase have an adjacent ABC transporter operon.	1.01947e-167
NC_015957.1\|WP_014056019.1\|2882450_2882648_+\|DUF397-domain-containing-protein	gnl\|CDD\|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	1.83272e-25
NC_015957.1\|WP_014056020.1\|2882662_2882959_-\|hypothetical-protein	gnl\|CDD\|225225	COG2350, COG2350, Uncharacterized protein conserved in bacteria [Function unknown].	6.38687e-14
NC_015957.1\|WP_014056016.1\|2879901_2881080_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|275041	TIGR04188, conserved_hypothetical_protein, methyltransferase, ATP-grasp peptide maturase system. Members of this protein family are predicted SAM-dependent methyltransferases that regularly occur in the context of a putative peptide modification ATP-grasp enzyme (TIGR04187, related to enzymes of microviridin maturation) and a putative ribosomal peptide modification target (TIGR04186).	1.79222e-76
NC_015957.1\|WP_043235830.1\|2878400_2879579_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	6.13614e-13
NC_015957.1\|WP_014056002.1\|2857863_2858829_-\|LLM-class-F420-dependent-oxidoreductase	gnl\|CDD\|274645	TIGR03557, F420_G6P_family, F420-dependent oxidoreductase, G6PDH family. Members of this protein family include F420-dependent glucose-6-phosphate dehydrogenases (TIGR03554) and related proteins. All members of this family come from species that synthesize coenzyme F420, with the exception of those that belong to TIGR03885, a clade within this family in which cofactor binding may instead be directed to FMN. [Unknown function, Enzymes of unknown specificity].	0
NC_015957.1\|WP_043238597.1\|2856962_2857877_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	1.98472e-34
NC_015957.1\|WP_014056018.1\|2882245_2882446_+\|DUF397-domain-containing-protein	gnl\|CDD\|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	5.97292e-27
NC_015957.1\|WP_014056017.1\|2881418_2882267_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	1.16079e-05
NC_015957.1\|WP_014056011.1\|2875155_2875836_+\|hypothetical-protein	gnl\|CDD\|377552	pfam05719, GPP34, Golgi phosphoprotein 3 (GPP34). This family consists of several eukaryotic GPP34 like proteins. GPP34 localizes to the Golgi complex and is conserved from yeast to humans. The cytosolic-ally exposed location of GPP34 predict a role for a novel coat protein in Golgi trafficking.	1.03403e-26
NC_015957.1\|WP_014056000.1\|2855333_2856443_-\|dimethyl-sulfone-monooxygenase-SfnG	gnl\|CDD\|274923	TIGR04021, LLM_DMSO2_sfnG, dimethyl sulfone monooxygenase SfnG. This family of FMNH2-dependent members of the luciferase-like monooxygenase (LLM) family includes SfnG, a monooxygenase that converts dimethylsulphone (DMSO2) to methanesulphonate. This step can be followed immediately by methanesulfonate sulfonatase (an alkanesulfonate monooxygenase - see TIGR03565) for the FMNH2-dependent conversion an inorganic form. [Central intermediary metabolism, Sulfur metabolism].	0
NC_015957.1\|WP_014056007.1\|2864965_2866435_-\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|143437	cd07119, ALDH_BADH-GbsA, Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like. Included in this CD is the NAD+-dependent, betaine aldehyde dehydrogenase (BADH, GbsA, EC=1.2.1.8) of Bacillus subtilis involved in the synthesis of the osmoprotectant glycine betaine from choline or glycine betaine aldehyde.	0
NC_015957.1\|WP_043235826.1\|2861033_2861828_+\|IclR-family-transcriptional-regulator	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	1.16741e-50
NC_015957.1\|WP_014056005.1\|2861860_2863411_-\|FAD-binding-protein	gnl\|CDD\|235000	PRK02106, PRK02106, choline dehydrogenase; Validated.	1.512e-135

>NC_015957.1|WP_014056010.1|2873532_2874195_+|hypothetical-protein
MRKPTHSFRGAALGVVAAAAVVAVAGTGPAQAHAPSDRAEAQAAAPQGTPGHLVPRELPPHSSSDWYASDVTPGLPETPPFCVEKTLPSAGATHRTFWTEYDTGATEIVVRTGTVEAARKLAAAAEKKIQNCAADWGRDYPQGTASGRDYGALTAEDGAHVYGVHTSYPDSEPGIHLFGVGRDGRTVTVVSWGEMGGYDQAPVADFKRTTTTAVVKLYHP
>NC_015957.1|WP_050993931.1|2867694_2871063_+|hypothetical-protein
MRELAGRARAASAEGRLGALIEELERRGAYERRLAAVAAAAGGRTGHLAARLADPDPVVRHRALDTARRGGPGAIPDDALAAAFEDAPATVRRALVRTVVAGRRTALADRLIEPFRERWGDGEAARLLPGCGAETVARLLPGLFHAVRAWRPLVSRHPVAVLDEAARQLTALPTLLRADWWTRYAPCVALAAPIEPQRVLELLEDHCHGPLPASVRARLSVLVAAEPGGALRLLLAPEHSGTRRRLDRAVLRRIVRADPPELAELGRALRHDADALARLLAALPPARRAAFYDAATDGRDPAHAVIEPAVLEVLPRPRRQAEARRMAAQARERGAPWTTVLESVAQLPVEEAREELLAAVRRSSAEDRALAYPLLIQCVARSGDPDALTDLLHLLERLRNEQDPVRSAALGALARTHPALFTDDAAEHLDRIAAEAISARDSSSATRQALRHLAVALLREHAVTGRRQLLGWALRTLTRLAGSVGAADLGRLDHQLRRGQEQAVSEALRPWLEAGAERVDHELTFALARSLGRRAHTLPELQELLWQAISFGSDTTVRTAIGLWLEPPAERDARVAELLTHEPSAAVLPPVLAVLTRRRTDLLDLVLDDTPPYGRFLTPGTHWTPPTGRNTGRWLPRQQAAAARLLDRAAADTSLRPQQRAAAVADAALIPGTGVATVRTWADAPDVVLADASDVVLAEAALAALARTDRPGDALPALLAHAGGDRARVAVYAATRAARYAEPSRLGRLMRGVLAPDGVATAVPPVPAKVTSRKEAVRLAATLLPVSDAAALLADAFELPGQHPDVQAACVAFATRPLDAERSWELLTAAASGRRELRHAVLRTRPLDLPEAHRGRYAQLIRVVCDTDDPEVAAAGYGALAGWSPWAPDAAAVLVAAVTDLGNRASWRPAADALLDLMAAAADGSPGDNPLAWALAALATADARPGGPDAEPDRDRPARRRIEHLADRLATRARMRPRVTRRTARAAGELLAGYETFVQEAAHVLVNALDLDARPGPLSAGLARLARLHTTRPALAVRTADALGRRLNTALRPGSDAGLLRAAGQLDEDGGHASGLFAATLTEVGGARTEWAEPWRERLRSLRGHPHADVRDAALRLTTTVE
>NC_015957.1|WP_014056007.1|2864965_2866435_-|aldehyde-dehydrogenase-family-protein
MPELFIGGHWTTALDGHSREIRCPADGSLVAVVDEAGPGDAAAAVAAARDAFDRGSWPGTPPADRGGLLLRVADLLEREKPTLARAESLDTGKRMVESEYDLDDIANCFRYFGNLASSAGAGRVVEVGSAEIDSRVVHEPVGVCVLITPWNYPLLQTAWKVAPALAAGNTFVLKPSELTPHTSIHLMRLLTEAGLPGGAANLILGSGATAGAPLVTDERVDMVSFTGGVVTGRWIMSAVAPTVKKLALELGGKNPNIVFTDCDFDTAVDYALTAVFLHSGQVCSAGARLLVQEQLHDAFVDEIVHRARNIRLGGPFDEHARTGPLISAEHRQKIADYVAAGIDEGAVLRCGGTPPDDPDLEKGYYYLPTVLDDCTPDMSVVQEESFGPVLTVERFRDEDEAVALANDTVYGLAGGVWTQDAEKAQRVASRLRAGTVWINDFHPYVPQAEWGGMKQSGIGRELGPSGLHEYQELKHIWRNTAPRPQRWFE
>NC_015957.1|WP_014056006.1|2863421_2864969_-|amino-acid-permease
MTASGSAGPPPKPRPDGSHDDDSLAELGYRPELKRTLGNFHTFAAGISYISILTGTFQLFYFGVAHGGPAYWWSWPMVFSGQLMVALSFAELAGRYPVAGSVYNWSKLLGGPHVGWLGGWMMMTASMVSLAAVALAYQVTLPQISSLFQFIGDGSTGTERAANAVLLGSVLILFTMVINGFGVKLMARINSAGVAIELIATVVLILLLAAHLARGPSVVLDTFGRGHGEPLGYLGAFLTASLASAYVMYGFDTASSLGEESVDPGRNAPRAILRALVASFALGGLILLFALMAVPNLHDKRLAVDGLQFVVLSALGHGVGLMVLWCVVVAITVCALAVHTAAIRLMFAMARDNNLPGGSRLARVHPRFQTPVLPAVLIGLVAIAILVLNINQPQIFSVVTSIAIIMIYVAYLMVTLPMLVRRLRGQWRPAEDRFSLGRLGLPVNVLAVLWGTAMTVNLAWPRAEVYNATGPHHWYLRWGAVLFVGAVALGGFTYYWFVQRTRTGVLAEHAAATTP
>NC_015957.1|WP_014056005.1|2861860_2863411_-|FAD-binding-protein
MDQFDYVVVGGGTAGSVVASRLSEDPSVSVCLLEAGPSDLGDDNILRLNRWMWLLESGYDWDYPIERQEKGNSFLRHARAKVLGGCSSHNSCIAFWAPAEDLDAWAAMGLDGWSAADCFPLYQRLEDNDAPGDHHGRGGPVRIRTVPPEDPCGRAVLAACEEVGIPIAPFNTGTTVVRGANWFQINAREDGTRCSASVAYLHPVMDSRPNLEVRTGLQAKRLVLDENLRCTGVDYLSPDLIRTLRVHARREVIVSCGAIDTPKLLMLSGIGPAGHLRETGVEVLVDSPGVGGNLQDHPEGVIMWNAEQPMINTSTQWWEIGIFTATEPDLDRPDLMFHYGAMPFDLNTYRRGYPTSENAFSLTPNVTRARSRGTVRLATRDFRDKARVDPRYFTDAYDIDIMTHGLLLARKIAARPALAMWAGAELAPGPDVHSSNELAAYIRETHNTVYHPACTVRMGAPDDPDAPLDPLLRVKGVTGLRVADGSAMPYLIAVNPCITTMMIGEKCADMIKQGRP
>NC_015957.1|WP_043235826.1|2861033_2861828_+|IclR-family-transcriptional-regulator
MAETGGVREVKSAGRTVELLELLAARGEQPARLRELAEELRVPRSSMYALLKTLIDRGWVRTDVTGSLYGIGIRALLTGTSYLDSDPRVRAARPYLDEASDALGETIHLARLDGGDVVYLATRESHEYLRPFSRVGRRLPAHVGALGKALLAERIDGELPLTGEELAPMTPNTHRTRVALVADLARVRERGHAVDREEGVVGIVGFGFALRYDVPAVDAISCSVPTARLAEGREERIVGVMREIRAKIEAVVPRGAGTGPQWRP
>NC_015957.1|WP_014056003.1|2858941_2860912_-|hydrolase
MPSIPHVLRRLLLLVMTASLCAVGLSIGATARAAAPGNGSVTDPNIAYTGRWDLGSTTAAVPNWTGGYLQTAFTGTTVKIKARDAVNFYASVDGGADVFYAGVRGTVNLTPTPLPQGNHTLRVSYRSGDTVFQGLVLDSGAGTVAPRVPSGLIEFVGDSITAGALTDRLALDSYGWKTGEQLGMRHTQIARSGYCLVGKDGCVGLAAQFFKTASTGDQNWDFSRYQANAVVINLGTNDIGHGVTGAEFQSAYTALLRDIRAKYPNAALFAVQTLKKRYLTETRAAVSARNGAGDAKVYYVDTSGWLTDGTDYEDGNGHPNEAGHTKFANRLAPAISAKLGTAGVKAAAPGRPGDPHITFSGRWDTKTSTTAYTPYWAGAYFRTGFTGRTVKLEQRGAIDLWASIDGGPATFYDEAKGTVNLTPTPLAAGNHTLQVNYQVIAGSYHGDAVFQGLTLDSGATTFTPPAPKKLIEFVGDSITVGTTTSQNARTAYGWLIGERLGADHTQIAQGGAALVDTADDRMSLEQQFTKLNPNAATPDWDFSRYQANAVVINLGTNDVGRGVSSAQFQASYTSLLRKVRTAYPNAWIFALRTFSGRFGTETKAAVTAFGDAKSSSVDTTGWLASDDLSDSVHPNDKGHRTITDRLAPLISAKLQA
>NC_015957.1|WP_014056002.1|2857863_2858829_-|LLM-class-F420-dependent-oxidoreductase
MVRWGYTMMTEQAGPRQLVDDVVRAEQVGFDFSVTSDHYFPWLDSQGHAPYAWSVLGAAAQATSSIPLTTYVTCPTVRYHPAVVAQKAATLQLLSEGRFRLGLGSGENLNEHVIGQGWPSADVRHEMLEEAIEIIRALFGGGYVTHHGTHYDVDSAKLWDLPDQPPPIGVAVSGPQSCRLAGRLADILIAVEPKSELVGDFERNGGGGKPRIGQIPVCYDPDRDAAIARAHDQFRWFGSGWKVNSELPGPASFAGATQFVRPEDVAASIPCGDDVGEFTELIRPFVDAGFTDVALVQIGGDHQRPFLDWAEERLLPALREL
>NC_015957.1|WP_043238597.1|2856962_2857877_+|LysR-family-transcriptional-regulator
MRIEQLEYIAAVTRLGSLRRAAEELHLSQPALSETVRNLERELGVDLLERKRSGATISAEGRELLPHIATVIEAVDRLRDAAGDQHRVSRMIRLGTVNTATVPLLIPAVREFRATHPVTQVEVVGAQQTEIHRALLEGSVDLGLVNYLGGDDVPPDLETTELLRGRPVVCLRPDSPLAARPVVSAADLLDGREPLIVMRSGYLMHRFIHRLLAGRTPSFSYSTDGAEMGKLMVAEGLGVTVLPDFSVIGDPLERGGAITHRPLADGEATEVLLVIQRRRSGSVPRAVRDLHQLFVRRAGTPTAP
>NC_015957.1|WP_014056000.1|2855333_2856443_-|dimethyl-sulfone-monooxygenase-SfnG
MPAEPLRFAYWVPNVSGGLVTSTIEQRTDWGYDYNRDLAVLAENNGFDYALSQVRYMASYGAEYQHESTSFSLALLLATQRLKVIAAVHPGLWHPGVLAKLGATADQLSDGRFAVNVVSGWFKGEFTALGEPWLKHDERYRRSEEFIRALRAIWTKDHAELAGDFYRIRDFSLKPKPLSSPGRPHPEIFQGGNSTAARAMAGRVSDWYFSNGKDFDGVTEQIGDVRAAAATVGRPAPGFALNAFLIARDTEAEARETLREIVAKADTEAVDGFRGAVQQAGRSTADGKGMWQDSSFEDLVQYNDGFRTGLIGTPEQIAERIVAYKRLGVDLFLLGFLHYLEEVEYFGKRVLPLVRELEAELPEPVPALS
>NC_015957.1|WP_014056011.1|2875155_2875836_+|hypothetical-protein
MPNGSLSLAASLYLLSYDAETGMPTGAHTALLVRAAALTELVQRGMLIDTDGSPCPVADAATGDRALDGLLELIGESRPRSWQIWVGHQPRLTEHAVRDQMVAAGYVRAKGRRVLGLFRAKEYTLERPDQVAGMRDDAVRVLHGEQSAAEVSERDAALVTLAAAGELRAVVTATDAKVRKHRILELGERCGGRGPVLEKVIAQVRTALAAAVATAMLAATTTATAT
>NC_015957.1|WP_014056012.1|2876110_2876524_-|SsgA-family-sporulation/cell-division-regulator
MTTVIDQAVQAQLIASTPESRAIPACLRYERDDPFAVRVSFPPSASLDGSAVEWTFGRELLSAGLRGPAGSGDVQMWPCGPRRTVLEFHAPEGMAMVQFDTADLRRFLGRSYAIVPEGSEAGELDLDQGLASLLRDA
>NC_015957.1|WP_014056013.1|2876752_2878249_+|sigma-70-family-RNA-polymerase-sigma-factor
MTEGHAPLDAAAYSRIYEAEYSRLCGYARTLTGNPWVAGDLVAEAHYSVWRRLRAGHPLGADAVPAELTSAVRELSAGAGGWGPAQQASYLEPLVQVLHELPQRWVKALWLAEVDGLPPQEVAWRTGVSPDGAAALVERVQGSVRQEFLRAQPGYPASAACGEHWERLPGHVQGADSPDQAERIAVHIDGCRDCRGRMEQLVAADDRLPALTGPALLALYDRGMARFLAPLAAAAAVGAVGAAGVGVLAAGGAHAAPSNGPLVSSRRSMRHLVRGQVRQAGPVAVAAAAGGVLLVAGAAGMTGLALTDGGSAEAQQPAGASAPSISDTSDSSDSSSSSASSGSSSASGTSATSGASRHSGGSRAGTPGEASRNRPSTSSVPTGHSPADVPSSAVSPSRKTPSSSASPSSRPSSPDSPSSSASSSPSGSPSHQPTDEPTGKPTDGGTKDPEGTPSGQPTDEPTQQPTEEPTQRPTAKPADPGSDDSRGCVSLVVRLCVR
>NC_015957.1|WP_043235830.1|2878400_2879579_+|helix-turn-helix-transcriptional-regulator
MGTSVGERLREVRKRRGLSQRELAQESGVSLSWIRKLEQGTETDTRLETARKLAHTLRVSTSYLVAESSEPGADTATVDRWAPVRRALEQPARADGLEDAPTVAGVKEALDAAMPLFKGDRFTELGTILPRLLREADILAEVDPDGRAVRVRLLQLTGWLMVQTRQFGAANLALDLALDMSADRLQGASTVNTMCWLLLRQGKLTEARELAVQWADDTEPRMSRATPEELCTWGWLLLRVSAASVRDNRPGEARDALRLAHSAAVVLGREYQPREDFLRTFGPATVALKRTENAGIVDRPDRVLDLAAKIPTDTLRPTSNNRNRHRLDVADAYAKTRRYAEAVGELNTIWQNSPEWLPTQRYARDILGRVIQKRRTLTPDMRVLADVIGVPM
>NC_015957.1|WP_014056015.1|2879764_2879905_+|hypothetical-protein
MTNVQIYTAAGGDGDGDGHPGTPWTPPQDPPSPDGDTPPGDGTHRK
>NC_015957.1|WP_014056016.1|2879901_2881080_+|methyltransferase-domain-containing-protein
MTLNPAQVDRPSRKELGRALLETHSLASDWAPTFAAVDRAVFLPALMWPFDMDKGESVPVDRDMNSDAWYAAADSNVPIVTQWDDGKHMGTAPGKVSTSSSSMPSVVYAMLQALEVDAGMKVLDVGTGTGETAGALAYRLDAQNVTTIEVDRAVSARARERLCAAGLHPEVVVGDGFAGCADRAPYDRILATVGLREIPGAWIEQTRPGGLIVAPWGTHYSHADAVARLSVKDGQASGHFTRPVEFMKLRAQRLSLAEHAEYAPPDAMERADASTTAITEAEFVTGKYTAVPFALGLRVRDCTQAVADKREDARPVWFYGLSDRSWACVMFRDGQAEARVWQSGPRRLWDEVETAYRWWVGHGEPDHTRFGLTVTPEGQRAWLDDPAESWAV
>NC_015957.1|WP_014056017.1|2881418_2882267_+|helix-turn-helix-domain-containing-protein
MSFRSRELFPDRSARDLLGAEIRRHREKADMSLRRLSEVLNYSKSHLARIEAAESLPYDDLPAKLDACFGTDGLFARLYALAKNEPFPGKYRRMIELESQAVVIEKYVGATFPGLLQTPELAEHSLRCGFPHAPDAEIQAMVKARIDRQVLLDRAKPPRCWFILDEAVLYRPVGGPAVMRDQLSSLLERGTQSHVTIQVLPFSAGGHIEAGGSLTLFTAHGESPVAYDESSQSGMIIEDQEDVAQRRENYDLLRAMALSPRDSEAMIRAVMEDWTPCQPPRT
>NC_015957.1|WP_014056018.1|2882245_2882446_+|DUF397-domain-containing-protein
MPTTPDLSTAAWRKSSYSNNNGGDCVEVADNLPGLVPVRDSKNPHGPALIFAAGSWATFIASLKMG
>NC_015957.1|WP_014056019.1|2882450_2882648_+|DUF397-domain-containing-protein
MPTTPDLSTAAWRKSSYSNGDGGDCVEVADNLPGLVPVRDSKCPDGPALMFPAGSWATFIASLKA
>NC_015957.1|WP_014056020.1|2882662_2882959_-|hypothetical-protein
MFVLEITYTASADRVEAARPEHLAWVDDHFANGTFLASGPKNPRDGGVILALGDDRARIEEMVASDPFIVAGIGEYTITEFLATRTATALAEHRQERP

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Crispr_ID: NC_015957_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015957_10

2996821-2996950

Orphan

Consensus_repeat	Method
GCCGGGTGCGGCCCGGTGGCCGGGTTGTGCCCACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015957_10

>merge|NC_015957|10|2996821-2996950|CRISPRCasFinder
GCCGGGTGCGGCCCGGTGGCCGGGTTGTGCCCACCGCGTTCCGCCTCGCGGACGGCCTGGGGCCGGCACGGGCGTTGGCTCTTGGCGTTTTCGTTGCCGGGTGCGGCCCGGTGGCCGGGTTGTGCCCACC

>NC_015957|10|9|2996821-2996950|CRISPRCasFinder
GCCGGGTGCGGCCCGGTGGCCGGGTTGTGCCCACC	GCGTTCCGCCTCGCGGACGGCCTGGGGCCGGCACGGGCGTTGGCTCTTGGCGTTTTCGTT
GCCGGGTGCGGCCCGGTGGCCGGGTTGTGCCCACC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015957.1\|WP_043235850.1\|3004160_3005378_+\|serine/threonine-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272
NC_015957.1\|WP_014056108.1\|2996337_2996721_+\|50S-ribosomal-protein-L20	unknown	unknown	gnl\|CDD\|179959
NC_015957.1\|WP_014056106.1\|2995280_2995898_+\|translation-initiation-factor-IF-3	unknown	unknown	gnl\|CDD\|234582
NC_015957.1\|WP_014056107.1\|2996046_2996241_+\|50S-ribosomal-protein-L35	unknown	unknown	gnl\|CDD\|234676
NC_015957.1\|WP_014056100.1\|2988460_2989657_-\|alanine-racemase	unknown	unknown	gnl\|CDD\|143488
NC_015957.1\|WP_050993938.1\|2990226_2990928_+\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014056116.1\|3007763_3008021_-\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014056103.1\|2992695_2993478_+\|SseB-family-protein	unknown	unknown	gnl\|CDD\|377787
NC_015957.1\|WP_014056117.1\|3008539_3008998_-\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014056105.1\|2994472_2994838_-\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014056109.1\|2997227_2998061_+\|RNA-methyltransferase	unknown	unknown	gnl\|CDD\|223640
NC_015957.1\|WP_014056118.1\|3009008_3009779_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|143636
NC_015957.1\|WP_014056114.1\|3005789_3007127_+\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014056102.1\|2990924_2992142_+\|type-VII-secretion-associated-serine-protease-mycosin	unknown	unknown	gnl\|CDD\|274856
NC_015957.1\|WP_014056115.1\|3007175_3007739_+\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|239516
NC_015957.1\|WP_014056110.1\|2998105_2999302_+\|histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NC_015957.1\|WP_014056111.1\|2999522_3000644_+\|phenylalanine--tRNA-ligase-subunit-alpha	unknown	unknown	gnl\|CDD\|234780
NC_015957.1\|WP_014056104.1\|2993584_2994385_+\|aquaporin	unknown	unknown	gnl\|CDD\|235453
NC_015957.1\|WP_050993659.1\|2992088_2992451_-\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014056112.1\|3000643_3003169_+\|phenylalanine--tRNA-ligase-subunit-beta	unknown	unknown	gnl\|CDD\|234804

Protein	Function_ID	Function_description	E-value
NC_015957.1\|WP_043235850.1\|3004160_3005378_+\|serine/threonine-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	4.78613e-34
NC_015957.1\|WP_014056108.1\|2996337_2996721_+\|50S-ribosomal-protein-L20	gnl\|CDD\|179959	PRK05185, rplT, 50S ribosomal protein L20; Provisional.	8.34517e-61
NC_015957.1\|WP_014056106.1\|2995280_2995898_+\|translation-initiation-factor-IF-3	gnl\|CDD\|234582	PRK00028, infC, translation initiation factor IF-3; Reviewed.	1.70155e-94
NC_015957.1\|WP_014056107.1\|2996046_2996241_+\|50S-ribosomal-protein-L35	gnl\|CDD\|234676	PRK00172, rpmI, 50S ribosomal protein L35; Reviewed.	5.7669e-20
NC_015957.1\|WP_014056102.1\|2990924_2992142_+\|type-VII-secretion-associated-serine-protease-mycosin	gnl\|CDD\|274856	TIGR03921, T7SS_mycosin, type VII secretion-associated serine protease mycosin. Members of this family are subtilisin-related serine proteases, found strictly in the Actinobacteria and associated with type VII secretion operons. The designation mycosin is used for members from Mycobacterium. [Protein fate, Protein and peptide secretion and trafficking, Protein fate, Protein modification and repair].	1.05471e-88
NC_015957.1\|WP_014056112.1\|3000643_3003169_+\|phenylalanine--tRNA-ligase-subunit-beta	gnl\|CDD\|234804	PRK00629, pheT, phenylalanyl-tRNA synthetase subunit beta; Reviewed.	0
NC_015957.1\|WP_014056109.1\|2997227_2998061_+\|RNA-methyltransferase	gnl\|CDD\|223640	COG0566, SpoU, rRNA methylases [Translation, ribosomal structure and biogenesis].	2.72223e-68
NC_015957.1\|WP_014056115.1\|3007175_3007739_+\|NUDIX-hydrolase	gnl\|CDD\|239516	cd03424, ADPRase_NUDT5, ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+, for its activity. It also contains a highly conserved 23-residue Nudix motif (GX5EX7REUXEEXGU, where U = I, L or V) which functions as a metal binding site/catalytic site. In addition to the Nudix motif, there are additional conserved amino acid residues, distal from the signature sequence, that correlate with substrate specificity. In humans, there are four distinct ADPRase activities, three putative cytosolic enzymes (ADPRase-I, -II, and -Mn) and a single mitochondrial enzyme (ADPRase-m). Human ADPRase-II is also referred to as NUDT5. It lacks the N-terminal target sequence unique to mitochondrial ADPRase. The different cytosolic types are distinguished by their specificities for substrate and specific requirement for metal ions. NUDT5 forms a homodimer.	1.71971e-23
NC_015957.1\|WP_014056118.1\|3009008_3009779_-\|hypothetical-protein	gnl\|CDD\|143636	cd07302, CHD, cyclase homology domain. Catalytic domains of the mononucleotidyl cyclases (MNC's), also called cyclase homology domains (CHDs), are part of the class III nucleotidyl cyclases. This class includes eukaryotic and prokaryotic adenylate cyclases (AC's) and guanylate cyclases (GC's). They seem to share a common catalytic mechanism in their requirement for two magnesium ions to bind the polyphosphate moiety of the nucleotide.	0.00049065
NC_015957.1\|WP_014056111.1\|2999522_3000644_+\|phenylalanine--tRNA-ligase-subunit-alpha	gnl\|CDD\|234780	PRK00488, pheS, phenylalanyl-tRNA synthetase subunit alpha; Validated.	0
NC_015957.1\|WP_014056103.1\|2992695_2993478_+\|SseB-family-protein	gnl\|CDD\|377787	pfam07179, SseB, SseB protein N-terminal domain. This family consists of several SseB proteins which appear to be found exclusively in Enterobacteria. SseB is known to enhance serine-sensitivity in Escherichia coli and is part of the Salmonella pathogenicity island 2 (SPI-2) translocon. This entry contains the presumed N-terminal domain of SseB.	2.79161e-21
NC_015957.1\|WP_014056110.1\|2998105_2999302_+\|histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	9.10301e-53
NC_015957.1\|WP_014056104.1\|2993584_2994385_+\|aquaporin	gnl\|CDD\|235453	PRK05420, PRK05420, aquaporin Z; Provisional.	3.04125e-68
NC_015957.1\|WP_014056100.1\|2988460_2989657_-\|alanine-racemase	gnl\|CDD\|143488	cd06813, PLPDE_III_DSD_D-TA_like_2, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2. This subfamily is composed of uncharacterized bacterial proteins with similarity to eukaryotic D-serine dehydratases (DSD) and D-threonine aldolases (D-TA). DSD catalyzes the dehydration of D-serine to aminoacrylate, which is rapidly hydrolyzed to pyruvate and ammonia. D-TA reversibly catalyzes the aldol cleavage of D-threonine into glycine and acetaldehyde, and the synthesis of D-threonine from glycine and acetaldehyde. DSD and D-TA are fold type III PLP-dependent enzymes, similar to bacterial alanine racemase (AR), which contains an N-terminal PLP-binding TIM barrel domain and a C-terminal beta-sandwich domain. AR exists as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. Based on their similarity to AR, it is possible members of this family also form dimers in solution.	0

>NC_015957.1|WP_014056108.1|2996337_2996721_+|50S-ribosomal-protein-L20
MARVKRAVNAHKKRRAILEQASGYRGQRSRLYRKAKEQVTHSLVYNYNDRKKRKGDFRQLWIQRINAAARANGMTYNRFIQGLKAANIEVDRKILADLAVNDAGAFAALVEAAQKALPSDINAPKAA
>NC_015957.1|WP_014056107.1|2996046_2996241_+|50S-ribosomal-protein-L35
MPKNKTHSGASKRFKLTGSGKVVRQRAGRRHLLEHKPSTLTRRLAGKVELAPADAKKIKKLLGK
>NC_015957.1|WP_014056106.1|2995280_2995898_+|translation-initiation-factor-IF-3
MSAEPRINDRIRVPEVRLVGPSGEQVGIVPLAKALELAQEYDLDLVEVAATARPPVCKLMDYGKFKYESAMKAREARKNQAHTVIKEMKLRPKIDPHDYDTKKGHVVRFLKQGDKVKITIMFRGREQSRPELGYRLLQRLAEDVQELGFVESSPKQDGRNMIMVLGPHKKKTEAMAEAREAQAARKAERQGVSSVEEPAEEPAEA
>NC_015957.1|WP_014056105.1|2994472_2994838_-|hypothetical-protein
MSDANAGQPPAPDFDRMTRDIADVPAVEVITTVAVHLMSAAAVNLGLAEEGPQHKDLDEARKLINALAGLVTASATEISSFHAAPLRDGLKSLQLAFREASVVPDEPGQGPGEKFTGPVFG
>NC_015957.1|WP_014056104.1|2993584_2994385_+|aquaporin
METRTVVAEFIGTAMLVLFGVGSLVLAGDYINALGISLAFGFTLIAIAYAFGRISGCHINPAVTLGVLLAKRIDIRTAVQYWVAQFVGAIVGAAVLFLLANQVPRLQTADAFGSNGYGGRSPVGMGAGGAFLAEVLLTFLLVFVFLAVTHSVALVGGEPIPVGLALAAVNLIGIPLTWASVNPARSFGPAIFAGGDALGQLWLFIVAPLVGGVLAAVVHRFTHLQPAGQADQEEAHPPPATGPWGRLRGGHRPEAGGQETKGPEAA
>NC_015957.1|WP_014056103.1|2992695_2993478_+|SseB-family-protein
MALKNIPDPGFSGDDGSADPRLTAALAAWADDRSAEPEVLAALTDARLLVPVMAILGEVEEVESKPREASVEGGGGRRAGGLRREKSSDMAVPTLEAPGGRRALPAFTSLESLARWRPDARPVAVPLRQALEAAAHEKADTLVLDLAGPVPYQLTGPALLALAEGRTSTDPLADPAVTEAVRAVLAAEPEVLRAHLAPAADADGMLALALAPEAPARETAHRVAGALAADEVLRARLVRGLTLALLPPDAKVPGEPLFSR
>NC_015957.1|WP_050993659.1|2992088_2992451_-|hypothetical-protein
MGILAARLLRAEDEGRPLTAQERSHAAVMIEQSDNGAATALWQTIGGAAGLDAAHQRLGLTATRAGSGGNWGVTMTTAVSQHARIPTTSARRARADGAAGDVASARADSREQRAESRGHP
>NC_015957.1|WP_014056102.1|2990924_2992142_+|type-VII-secretion-associated-serine-protease-mycosin
MTGIGRRLAVALTAAGLTLVLATPANADGIQAQEWALDTLHVHQAWQTTKGSGVTVAVLDTGVDDGHPDLEGQVLPGKDLIGFGARRGERAWARHGTAMAGIIAGHGHGAAGGEGVLGVAPKVRILPVRVILEDSDAARKKARSSRGGALAAGIRWAADHGADVINLSLGDDSASAHPEAAEDAAVQYALGKGVAVVASAGNGGEKGDRVSYPAAYPGVIAVTAVDRYGSRAAFSTRRWYATVCAPGVDVVIADPDKRYYEGWGTSAAAAFVSGSVALVRAAHPELSPRQIRDLLTRTAQDVPEGGRSDALGAGLVDPAAAIAAGGKMKPEAQRPAVASAPQRYFGNGPGHALGAHGDSGPNEMALLAGIAGAAVVVAAVALWRGSGPLRMPPRLRTLLTGIRPR
>NC_015957.1|WP_050993938.1|2990226_2990928_+|hypothetical-protein
MLGGAAAGSWLGDDPDAPPSTADTYAHARSAWHSVPVDDLFPRTLRGKGEGPGGADRVWSRIAVAPDSSCGGGFDPLLAKALAPVGCKRLVRATYTDATSTSVTTVGLLITTSGPTGMRTLHQRFVTEKLDERTDLMPRAYAAKGTAAAGFGDDQRASWRIRILTDAPVVVYSVSGFADGRKVTDPQSAGEATQRGATSAPAQSGLGNDARGIADAIEPIFRRALSTITETTS
>NC_015957.1|WP_014056100.1|2988460_2989657_-|alanine-racemase
MSAAAADRARYDRATAHLEAPVAIVDLGAFDDNARDLVTRAGGKPIRVASKSVRCRALLERVLAQDGFAGIMSFTLPESLWLAREGFDDVLLAYPSTDRDGFATLTSDPKPAEAVTVMVDDLSQLDLIDSVRAGTEEVRVCLELDTSLRMLGGRVRVGALRSPLREPEQLAELARAIDRRPGFRLVGLMAYEGHVAGVGDAVPGSPLRSRAVRLMQSVARRELAARRAAVVRAVRAVADLEFVNGGGTGSVQHTAAEDAVTEIAAGSGLYQPRLFDNYTSFHGRPAALFAQPVVRRPGVGVVTVLGGGYPASGAPGRDRLPVPYLPEGLVYDSMEGPGEVQTPLLGTAADDLLIGDKVWFRHAKAGELCERFDTLRLIEGDRVVADAPTYRGEGRTFL
>NC_015957.1|WP_014056109.1|2997227_2998061_+|RNA-methyltransferase
MAAPELTSLKSPRVTAARRLAKRSFRGKERRFIVEGPQAVREAIAYLVEVYATPEAAERHADILAAARAANLPVLTASDEVIAEMSDTVTPQGVVGLCRFLDSPFEEILRARPRLVAVLANVRDPGNAGTVLRCADAAGADAVVLTDASVDPYNPKAVRASVGSLFHLPVAVGVPVERAVSGLREAGARVLAADGAGERDLDSELDDRLLGAPTAWIFGNEAWGLPEATRALADEVVRVPIHGRAESLNLATAAAVCLYASARAQRAPAGCRSVTST
>NC_015957.1|WP_014056110.1|2998105_2999302_+|histidine-kinase
MDVRTSGARAADAHAPGAGPPGGGRDLSSTGPGPGLPGGAPDGFAPHPDDLPDGLVVADETGLVTCFNAAAARITATDPADAIGRRLEVALPLEDLDGRRWWALTDPYGGLAIRAGQPERNLLLPGGREVLVSARYVRERPTGPVRRVVVCLRGTEARRRTERSHAELIATVAHELRSPLTSVKGFTATLLAKWERFTDDQKRLMLETVDADANRVTRLIAELLDISRIDSGRLEVRRQPVDLAAAVRRHVQALTAAGHTAERFLIRARGPLPRLWADPDKIDQVLGNLLENAVRHGEGTVTIDIAPATPAKPVVEGPPVERTAVTVSDEGPGIPEESMSRVFTRFWRGSKRGGTGLGLYIVKGIVEAHGGTITVERARGGGAEFRFILPVGTPAYLA
>NC_015957.1|WP_014056111.1|2999522_3000644_+|phenylalanine--tRNA-ligase-subunit-alpha
MSAPNKSYDPVEVEALKPEEIARRRDEALAAIAAAGDLEALREVKVAHTGDRSPLALANREIGALPPHAKADAGKRVGQARGQVNQALKARQEELEAERDARVLVEEAVDVTLPYDRTPAGARHPITTLSERIEDVFVAMGYEVAEGPEVEAEWFNFDALNFPPDHPAREMQDTFFVRGAKDGESSGVVLRTHTSPVQIRSMIDREPPIYVICPGRTFRTDELDATHTPVFSQVELLAIDEGLTMADLKGTLDHMVRALFGEGMTTRLRPNFFPFTEPSAEMDMLCYVCRGESVGNPDRPCRTCSSEGWIELGGCGMVNPRVLIACGVDPDKYSGFAFGFGIERMLMFRHNVEDMRDMVEGDVRFTRPFGMEI
>NC_015957.1|WP_014056112.1|3000643_3003169_+|phenylalanine--tRNA-ligase-subunit-beta
MRVPLSWLREYVDLPAGETGRDVQAKLVSAGLEVETVEQLGAGLKGPLVVGQVLAIEELEGFKKPIRYCQVDVGQANGTGEPQNIVCGASNFAVGDKVVVVLPGAELPGGFAISARKTYGKTSEGMICSASELGMSDDHDGIIVLPPEYEVGTDAIELLELVDEVLDIAVTPDRGYCLSMRGVARETATAYELPLRDPALIDVPAPNSHGYPVQVTDPIGCDRFTARTVTGLDPEAHSPIWLERRLQKAGMRPVSLAVDITNYVMLEIGQPLHAYDRSRINGAIGVRRAEPGEKLTTLDGSQRVLDAEDLVITDESGPIGLAGVMGGANTEIADATADAETGQAAGTTEVVIEAAHFAPVSVARTARRHKLSSEASRRFERGVDPEATSAAAQRTVDLLVLLAGGTAEVGVTEIIAPSAPHTITLPADHPDKVAGVSYGRETVVRRLQQIGCDVYGADDLTLTVPSWRPDLTDPNDLAEEVIRLEGYENLPSTLPRPPAGRGLTERQRLHRRVGRALAGAGYVEALNYPFIGEEVLDQFGLAADDPRRDLVRLVNPLSDAEPALRTTLLPGLLGALRRNAGRGEHDLALFETGLVFRATGHEPAAATVPVDRRPTDEEIAGLDAALPHQPRRVAVVLAGDREQAGWWGKGTPVSWADAVEAGRIVAREAGAELIVRQDQQDPWHPGRCAALLAVVDGEEILVGNAGELHPRVTKALGLAERTCAMEIELDRLEQAGTGRVEAPHVSTFPVATQDVALIVDASVAAADVETALREGAGELLESLRLFDVFTGEQLGEGRKSLAYALRFRAPDRTLTAEEIAASRDAAVSAAANRTGATLRGA
>NC_015957.1|WP_043235850.1|3004160_3005378_+|serine/threonine-protein-phosphatase
MIGTSAVGGAFVRRARSLREVTRVVPCLWVLGALCWALLTPHHTEVVTLLAAAPAIACASSGRRRCIVLLGGAGLLLALAPPTALEPDGDGREPHAALITCCAILGVAVACYLTAGRKLRLVRELEQLRAVATAAQDVVLRPLPARLDGIELAGGHLSASRGAAVGGDLYEALATPYGVRVIIGDVRGHGLAAIGTVVAVLGSFREAAHEEPLLSGVLRRLDRALERHLRARASEECPLDGHVDEEFVTVLLLEVGADGEVTALNCGHPWPYRLYEQPVGPAMARQTAPGDVLPPLGLFPLPAELPTARWRALGVGDTLVLHTDGAEDVRDAHGTFFPLRRALSEAAGPGPLVPAAVVAGVRSALLRHTGGRLADDVALLALRFDRCPLSATTALTRPPADIHRG
>NC_015957.1|WP_014056114.1|3005789_3007127_+|hypothetical-protein
MEPNTLLDSVLDEAGVSHAGLAAHVNEAGRARGMKLRYEHTAVARWLKGQRPRGQVPDLICEVLGERLHRALTLDDIGFDTPGSRRGPATSLSGFVERATALWRSDEQQRPHVVEAPAVTGTPAVIPVWEWENPPEDSDVSRRGLTRVSMTDIETLGAARAHYEQMYRKAGGVATRTRVVGFLNSEAAPLLRGSYADDTGRQLHRATGGLVAIAGICAYDSNTHGLAQRYFHQALRLAKASGDRGLGAYVIALLVNQSLFMKEYRQAVAFAESALRAAGSQITPALAADLYAMQAKAYARLGDGAGTLSCIRRAETAADRIRPGQEPDETGYVQPGLVNVQVAEALLSLGDLGGAREHATAAVGTPAHDRGRVHRLAMLTHIELRQGDVDRAGATAVEMTERARGMESQRLRDRLRAVREHLAVSGSAATAEAAALIDGALRVPL
>NC_015957.1|WP_014056115.1|3007175_3007739_+|NUDIX-hydrolase
MASRFDERWLTVRWKNLRERTVYENRWFRVNLADVRLPDGRHLDHYLIRLRPVAVATVVNAANEVLLLWRHRFITDVWGWELAAGVVEDGEDIADAAAREMEEETGWRPGPLRHLLSVEPSNGLTDARHHIYWAEEASYVGPPEDDFESDRREWVPLKMVPDLVARGEVPAANMAAALLLLHHIRLG
>NC_015957.1|WP_014056116.1|3007763_3008021_-|hypothetical-protein
MTTEPEQAALAVELTELRRTVEVGFTRVDGRLALLDHRGEQAEEDVNQLGGRMRILEHGRWPLPSIAALTGVTALALAIWQTAGH
>NC_015957.1|WP_014056117.1|3008539_3008998_-|hypothetical-protein
MTDELTLLAEAGATAVVATMATDLWQRTKDAVLGLFRRDDPDRSVAVGARLEENAALMRATVVPDDVRQSLSGIWALELAELLRREPTCRAPLARLTAEVDSALAGGSGTLALEQNNTARDSGTVFAVQHGDIHTTREAGRTARGDDGPRAT
>NC_015957.1|WP_014056118.1|3009008_3009779_-|hypothetical-protein
MEEVPEYRALFAVDIAGSAGRGDVALRQIREALSTALRESFARSGIDWEACLRQDLGDGTRVVFPAGTPKASLVHPLVHELTVRLRAHNRLAGPPTRVRVRMALHAGDVHIGPDGTVVGRPLEVLARLLDATPARAALAQTPEATTALLVSQHFHEETVCQGQPGIDPASFRHVSVREKEFAASAWLHVPACATPSAAESSGPGELTESGGSGGRAGQDRAADDEIPSNAKMISRASGHGVIYAVQSGTIHISGKT

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Crispr_ID: NC_015957_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015957_11

3194771-3194883

Orphan

Consensus_repeat	Method
GGCGGAGCCGCACATCGACACAGCCCCGCGCCCCTTCAGGGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015957_11

>merge|NC_015957|11|3194771-3194883|CRISPRCasFinder
GGCGGAGCCGCACATCGACACAGCCCCGCGCCCCTTCAGGGCGCCCGCCCTCGCCGGTCGCGCCCGAGGCGGCGGAGCCGCACATCGACACAGCCCCGCGCCCCTTCAGGGCG

>NC_015957|11|10|3194771-3194883|CRISPRCasFinder
GGCGGAGCCGCACATCGACACAGCCCCGCGCCCCTTCAGGGCG	CCCGCCCTCGCCGGTCGCGCCCGAGGC
GGCGGAGCCGCACATCGACACAGCCCCGCGCCCCTTCAGGGCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_015957.1\|WP_014056285.1\|3192703_3194176_+\|amino-acid-permease	unknown	unknown	gnl\|CDD\|129987
NC_015957.1\|WP_014056296.1\|3205927_3207232_+\|alginate-lyase-family-protein	unknown	unknown	gnl\|CDD\|377511
NC_015957.1\|WP_014056281.1\|3189228_3189390_-\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014056292.1\|3200397_3201780_-\|nitrate-reductase	unknown	unknown	gnl\|CDD\|132655
NC_015957.1\|WP_014056291.1\|3199503_3200361_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|375319
NC_015957.1\|WP_014056294.1\|3202823_3204056_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340951
NC_015957.1\|WP_014056290.1\|3198489_3199374_-\|NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223528
NC_015957.1\|WP_014056280.1\|3185984_3189125_-\|lantibiotic-dehydratase	unknown	unknown	gnl\|CDD\|377403
NC_015957.1\|WP_014056284.1\|3192196_3192403_-\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014056287.1\|3195015_3195816_+\|carbon-nitrogen-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|143600
NC_015957.1\|WP_014056277.1\|3182754_3183429_+\|ribulose-phosphate-3-epimerase	unknown	unknown	gnl\|CDD\|235515
NC_015957.1\|WP_014056278.1\|3183537_3184554_+\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|367868
NC_015957.1\|WP_014056286.1\|3194186_3194642_+\|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
NC_015957.1\|WP_014056293.1\|3201849_3202737_-\|isocitrate-lyase/phosphoenolpyruvate-mutase-family-protein	unknown	unknown	gnl\|CDD\|379346
NC_015957.1\|WP_043238697.1\|3197702_3198395_-\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014056288.1\|3195897_3197607_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|366721
NC_015957.1\|WP_014056282.1\|3189867_3191331_+\|GuaB1-family-IMP-dehydrogenase-related-protein	unknown	unknown	gnl\|CDD\|181127
NC_015957.1\|WP_014056283.1\|3191438_3192200_-\|DUF2637-domain-containing-protein	unknown	unknown	gnl\|CDD\|378511
NC_015957.1\|WP_014056295.1\|3204168_3205395_+\|ROK-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224851
NC_015957.1\|WP_106685878.1\|3184647_3185832_-\|lanthionine-synthetase-C-family-protein	unknown	unknown	gnl\|CDD\|271201

Protein	Function_ID	Function_description	E-value
NC_015957.1\|WP_014056285.1\|3192703_3194176_+\|amino-acid-permease	gnl\|CDD\|129987	TIGR00909, putative_amino_acid_transporter, amino acid transporter. [Transport and binding proteins, Amino acids, peptides and amines].	2.48514e-177
NC_015957.1\|WP_014056296.1\|3205927_3207232_+\|alginate-lyase-family-protein	gnl\|CDD\|377511	pfam05426, Alginate_lyase, Alginate lyase. This family contains several bacterial alginate lyase proteins. Alginate is a family of 1-4-linked copolymers of beta -D-mannuronic acid (M) and alpha -L-guluronic acid (G). It is produced by brown algae and by some bacteria belonging to the genera Azotobacter and Pseudomonas. Alginate lyases catalyze the depolymerization of alginates by beta -elimination, generating a molecule containing 4-deoxy-L-erythro-hex-4-enepyranosyluronate at the nonreducing end. This family adopts an all alpha fold.	3.43909e-97
NC_015957.1\|WP_014056292.1\|3200397_3201780_-\|nitrate-reductase	gnl\|CDD\|132655	TIGR03616, Putative_pyrimidine_permease_RutG, pyrimidine utilization transport protein G. This protein is observed in operons extremely similar to that characterized in E. coli K-12 responsible for the import and catabolism of pyrimidines, primarily uracil. This protein is a member of the uracil-xanthine permease family defined by TIGR00801. As well as the The Nucleobase:Cation Symporter-2 (NCS2) Family (TC 2.A.40).	3.88074e-105
NC_015957.1\|WP_014056294.1\|3202823_3204056_-\|MFS-transporter	gnl\|CDD\|340951	cd17393, MFS_MosC_like, Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters. The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.04742e-87
NC_015957.1\|WP_014056290.1\|3198489_3199374_-\|NAD(P)-dependent-oxidoreductase	gnl\|CDD\|223528	COG0451, WcaG, Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism].	6.8036e-33
NC_015957.1\|WP_014056288.1\|3195897_3197607_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|366721	pfam01593, Amino_oxidase, Flavin containing amine oxidoreductase. This family consists of various amine oxidases, including maze polyamine oxidase (PAO) and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.	3.09443e-49
NC_015957.1\|WP_014056287.1\|3195015_3195816_+\|carbon-nitrogen-hydrolase-family-protein	gnl\|CDD\|143600	cd07576, R-amidase_like, Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases). Pseudomonas sp. MCI3434 R-amidase hydrolyzes (R,S)-piperazine-2-tert-butylcarboxamide to form (R)-piperazine-2-carboxylic acid. It does so with strict R-stereoselectively. Its preferred substrates are carboxamide compounds which have the amino or imino group connected to their beta- or gamma-carbon. This subgroup belongs to a larger nitrilase superfamily comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), class 13 represents proteins that at the time were difficult to place in a distinct similarity group. It has been suggested that this subgroup represents a new class. Members of the nitrilase superfamily generally form homomeric complexes, the basic building block of which is a homodimer. Native R-amidase however appears to be a monomer.	1.14188e-121
NC_015957.1\|WP_014056277.1\|3182754_3183429_+\|ribulose-phosphate-3-epimerase	gnl\|CDD\|235515	PRK05581, PRK05581, ribulose-phosphate 3-epimerase; Validated.	6.78193e-134
NC_015957.1\|WP_014056278.1\|3183537_3184554_+\|transcriptional-regulator	gnl\|CDD\|367868	pfam04198, Sugar-bind, Putative sugar-binding domain. This probable domain is found in bacterial transcriptional regulators such as DeoR and SorC. These proteins have an amino-terminal helix-turn-helix pfam00325 that binds to DNA. This domain is probably the ligand regulator binding region. SorC is regulated by sorbose and other members of this family are likely to be regulated by other sugar substrates.	9.54637e-74
NC_015957.1\|WP_014056286.1\|3194186_3194642_+\|Lrp/AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	4.25499e-30
NC_015957.1\|WP_014056293.1\|3201849_3202737_-\|isocitrate-lyase/phosphoenolpyruvate-mutase-family-protein	gnl\|CDD\|379346	pfam13714, PEP_mutase, Phosphoenolpyruvate phosphomutase. This domain includes the enzyme Phosphoenolpyruvate phosphomutase (EC:5.4.2.9). This protein has been characterized as catalyzing the formation of a carbon-phosphorus bond by converting phosphoenolpyruvate (PEP) to phosphonopyruvate (P-Pyr). This enzyme has a TIM barrel fold.	9.84539e-72
NC_015957.1\|WP_014056291.1\|3199503_3200361_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|375319	pfam17765, MLTR_LBD, MmyB-like transcription regulator ligand binding domain. This domain is found in a family of actinobacterial transcription factors. The structure shows it has a PAS domain like fold and it is bound to Myristic acid.	2.40467e-45
NC_015957.1\|WP_014056280.1\|3185984_3189125_-\|lantibiotic-dehydratase	gnl\|CDD\|377403	pfam04738, Lant_dehydr_N, Lantibiotic dehydratase, C-terminus. Lantibiotics are ribosomally synthesized antimicrobial agents derived from ribosomally synthesized peptides. They are produced by bacteria of the Firmicutes phylum, and include mutacin, subtilin, and nisin. Lantibiotic peptides contain thioether bridges termed lanthionines that are thought to be generated by dehydration of serine and threonine residues followed by addition of cysteine residues. This family constitutes the N-terminus of the enzyme proposed to catalyze the dehydration step, via glutamylation of the substrate during lantibiotic biosynthesis. The enzyme dehydrates Ser/Thr residues in the precursor by glutamylation.	0
NC_015957.1\|WP_014056282.1\|3189867_3191331_+\|GuaB1-family-IMP-dehydrogenase-related-protein	gnl\|CDD\|181127	PRK07807, PRK07807, GuaB1 family IMP dehydrogenase-related protein.	0
NC_015957.1\|WP_014056283.1\|3191438_3192200_-\|DUF2637-domain-containing-protein	gnl\|CDD\|378511	pfam10935, DUF2637, Protein of unknown function (DUF2637). This family of proteins has no known function.	0.000363095
NC_015957.1\|WP_014056295.1\|3204168_3205395_+\|ROK-family-transcriptional-regulator	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	3.26706e-29
NC_015957.1\|WP_106685878.1\|3184647_3185832_-\|lanthionine-synthetase-C-family-protein	gnl\|CDD\|271201	cd04793, LanC, Cyclases involved in the biosynthesis of lantibiotics. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links called lanthionines (Lans) or methyllanthionines (MeLans) in addition to 2,3-didehydroalanine (Dha) and (Z)-2,3-didehydrobutyrine (Dhb). These unusual amino acids are introduced by the dehydration of serine and threonine residues, followed by thioether formation via addition of cysteine thiols, catalysed by LanB and LanC or LanM. LanC, the cyclase component, is a zinc metalloprotein, whose bound metal has been proposed to activate the thiol substrate for nucleophilic addition. Also contains SpaC (the cyclase involved in the biosynthesis of subtilin), NisC, and homologs.	5.97192e-112

>NC_015957.1|WP_014056286.1|3194186_3194642_+|Lrp/AsnC-family-transcriptional-regulator
MRLNDLDERIVHALAEDARRSYADIGELVGLSAPAVKRRVDRLRAEGAITGFTVRVDPVALGWETEGFIELYCRHNTSPDAIRRGLSRYPEVVSASTVTGDADAVVQVFTSDMRHFERVLERIAGEAFVERTKSVLVLSPLLRRFSSGAPT
>NC_015957.1|WP_014056285.1|3192703_3194176_+|amino-acid-permease
MLEHGAAPPATQQPEPDPPVGGLGARLMRRKPVERLVAEGGQGEGGSLRRSMGMWQLTMISIGATLGTGIFVVLGEAVPDAGPAVIVSFVIAGLTALFSALSYAELAGTIPVSGSSYSYAYATMGELIAWVCGWCLILEYGVSVAAVAVGWGEYLNELLDGTLGVTIPDALAAPPGDGGIFNLPALLVVLLAMAFLLGGAKESARANTVMVAVKIAALILFCAVAFTGIRAGNYTPFMPLGMAGVSAAGATLFFSYIGFDAASTAGEEAKNPQRDLPRAIMLSLIIVTALYCLVAAVAVGALPWKKFSGSEAALASIMKDVTGQDAWAVLLAAGAVVAIASVVLTVLYGQTRILFAMSRDGLVPKVFSTVHARTGVPRANTVIVSLFCGVLAAAIPLGQLADATSIGTLFAFALVNIAVIVLRRTRPDMPRTFRVPLSPLFPVIGFALCLWMMGSLQLVTWVVFGCWMAVGLVLYFAYGMRRSRLATAEK
>NC_015957.1|WP_014056284.1|3192196_3192403_-|hypothetical-protein
MTTDSLQPPDHSRLSAEPVFRPRDQGGDSERYPLEYCARVWEDFIRALGRIEADFVQRSDTPEPGVKA
>NC_015957.1|WP_014056283.1|3191438_3192200_-|DUF2637-domain-containing-protein
MTYTEPRPGGYGPPPTGHRHAPAPPPGERYEAAADYEMNPFPLPDPETIEGRWDLEGDLARLLQTTSPEESVHTTGPIGPVAPLHTPSPTHVRGRGKRRRVRFRLPTLPWLHVISLIFAAVTTIIVAMLSVLGGMISYGPLRYLASPSTSESMAAWWPLLVYGPWLVASLSVLRAALHRRGAAHSWAVVVLFSTIAVFLCVAHAPRNAPSMAVAGLPPVAALVSFHQLVRQITLTSPPRHALPRTRGERGVAR
>NC_015957.1|WP_014056282.1|3189867_3191331_+|GuaB1-family-IMP-dehydrogenase-related-protein
MRFLEPGTGRHVESSPVPYDLTYDDVFMVPSRSAVGSRQGVDLASPDGTGTTIPLVVANMTAIAGRRMAETVARRGGLVVIPQDIPIDVVTDVIRWVKSRDLVLDTPIVLAPTGTVADALSLLPKRAHGAGVVVEDGRPVGVVTESDLTGVDRFTQLSEVMSRELMVLDADIDPQEAFNRLDAAHRKLAPAVDADGKLVGILTRKGALRATLYKPAVDAGGRLRVAAAVGVNGDVEGRTKALLDAGADALVVDTAHGHQESMITALKAVRGLGPRVPVVAGNVVAAEGVRDLIEAGADIVKVGVGPGAMCTTRMMTGVGRPQFSAVLECAAEARKFGKHIWADGGIRHPRDVAMALAAGASNVMVGSWFAGTYESPGDLQHTADGRPYKESFGMASARAVRNRTSDESAYERARKGLFEEGISTSRMFLDPARPGVEDLIDSIIAGVRSSCTYAGAGSLEEFHERAVVGVQSAAGYAEGKPLHASWD
>NC_015957.1|WP_014056281.1|3189228_3189390_-|hypothetical-protein
MSIAVPAESAKEMSEFDLDVRVELDEPTAAQGAASVTPGASIIWCTIVAPACG
>NC_015957.1|WP_014056280.1|3185984_3189125_-|lantibiotic-dehydratase
MSEDHAMFHAEPTGMLRVPLLPHSATGTRAHLDPRDREQVRRYIDALLTDERVEEALAVSSPSLHRTVEALRAGAPMKPGALRKLTLSATRYVLRAASRATPFGLLAGVAPVSFGAAGRQVRLGTRHRKAVRPDGGWLTGVLTAWEGDLEVLRALRVVANDLGFARGQRWVLPCGYDAQDPAGSDEPAADERRREGRTAQEISVRHTAAVKTILAATRHPRPAGGLLKTLDEAYPNVPASAKEGLLLELVRQGFLLTELRPPLGETDPLRYAVDVLKSVGQADKAGELAAIGDLLEEYGAERLGAGLGRWKKALDAMGGLRADDRPIQVDMRLDAEVTLDREVLREAERAATALCLAAPDTMPTPELREYRDAFVERYGTGRAVPLADVLDPHTGLGPPGGYDHPKSERRTAEAGEPSERDRARNDFLAELALTAIASGEREVVLDDAALDRLRGSGAPPPAALELCAHLTAPSRRSLDEGDFTLVLSPSTGSPAPGALFGRFAYLLDDVEEVGELVRRSAADSARDGALQAHLDFLPLRGRDANVARVRPFWTERVAVGCFADRASPAVRGMGDLALAADPDRLYLVDASTGQEINPRVPTMLDPRRAPAAVRLLREVPTMGGWPSCVWTWGRLSTLHHLPRVRFGRTVLAPARWRLTDPGLFDSALPDAEWERRLDDWRARWNVPDRVAVGGGDHRVELDLTAPLHRMVLRRELGRSKDVTAYETPEDAGAGDGWLTTDSGAFSSELVIPLLPARPAPAESPAVRAPARRIRPVGPPVPRHSREWLYGRLSTYAGRQDEVLAEHLPRLLAALPPAVDRWFFIRYADPAGAHLRLRFHGDPATLHGELTPGVLDWVEQLRDLRLAGAFVIDGYEPETHRYGGHEAIEAAETVFHHDSVAALEQLRLRAAGAVTVEPQVLAAANYLDLARQVHGDRWTGWWLRDPRDEEHHAYFRERRAAALRLLDGGLRATFPAEGAAAALAALDARAAAMRAYASVAADPSVLASVLHMHHNRLIGTSRTSEGRSLAVARGLAQADHGRRRHLG
>NC_015957.1|WP_106685878.1|3184647_3185832_-|lanthionine-synthetase-C-family-protein
MGASGAALLLSELSRNDPGLRPTVHALLAAEAGYAGARGPGLITGLGSLGFAAKHAARSPRDYATVRGRVDATLRHRLAKVLDAEYGRMESDVPGADREHFDVVSGVTGLGRYFLAEPSDPEAVHDVLRYLVALTEPVRAAAGPLPGWFSPPWPAAVDPRRREWVLDLGLAHGIAGPLALLSLCWTRGLRVPGHDTAIRRIARWLMSWRQEDPDAGPGWPGTVSADQELAATRPALGPGRASWCYGAPGIARALQLAGVALGEDAWVHTAAEAMRAVFARPGGLRGMDDPGLCHGLAGLARITGRMADELDDASLSARADEIAERLCARFDPGTAFGFPTAPVLPLRPEPLDAPTFLEGAAGVALVLLGRSTPPAGTADGEDREVPWDAALLLA
>NC_015957.1|WP_014056278.1|3183537_3184554_+|transcriptional-regulator
MSTGRSATRMGPAELVQAAAMARRFYLEGKSKIQIAEEFGVSRFKVARVLETALERDLVRIEIRVPAELDAERSDALRARYGLRHAVVVESPADAEADTPDPENLGEVAADLLGELVTEGDVLGLAWGRSTIHMAAALHRLPPCTVVQLTGVYDAGTAERGSVEAVRRAAAVSGGEAHPIYAPMLLPDTATADALRGQTGIARAFEYFDKVTVACVSIGSWEAGISTVYDMLTEKERAHYENLGAAAEMSAHLFDAEGRRIGRDLGERCITVEADRLRRIPEVVAIAGGRRKAEAIGAVLRSGLVTSLVTDTAAADYLLAETTPAAHPALDRADPDGV
>NC_015957.1|WP_014056277.1|3182754_3183429_+|ribulose-phosphate-3-epimerase
MALQINPSILSADFSRLADEAKAVEGADWLHVDVMDNHFVPNLTLGVPVVESLGKVTETPLDCHLMIDDPDRWAPQYIEAGAGSVTFHVEAAAAPVRLAREIRAKGARASMALKPATPIEPYEDLLPELDMLLVMTVEPGFGGQAFLDIMLPKIRRTRQLIDKHGLQMWLQVDGGVSAATIERCAEAGADVFVAGSAVYGADDPAKAVQALRRLAEKATGTPGT
>NC_015957.1|WP_014056287.1|3195015_3195816_+|carbon-nitrogen-hydrolase-family-protein
MSPLRTALLQNSGHPGDPAGNLKVLDEAAARAAADGAGLLVTAEMFLTGYAIGGRGVRELAEPADGPSGRAVAEIAATHGLAILYGYPESHAGAVYNSARLVGADGAELANYRKSHLYGCFERASFTPGETPVVQATVGELTVGILICYDVEFPENVRAHALAGTDLLLVPTAQMHPFEFVAESVIPVRAFESQMYIAYVNRSGVEGEFDFVGLSCLAGPDGATCLRAGRGEELLLGDVAPKLLTTSRRINPYLRDRRPGLYSSLG
>NC_015957.1|WP_014056288.1|3195897_3197607_+|NAD(P)/FAD-dependent-oxidoreductase
MTSTVPTAVHDEQETQALEALPPMTMFGPDFPYAYDDFLAHPAGLGQIPATEHGAEVAVVGGGLAGLVTAYELMKMGLKPVVYEADRIGGRLRTVGFDGCDDALTAEMGAMRFPPSSTALQHYIDLVGLKTQPFPNPLAPDTPSTVVDLKGESHYARTIDDLPPVYREVADAWNACLEEGADFSDMNRAIRERNVPRIREIWSRLVGKLDNQTFYGFLCDSAAFTSFRHREIFGQVGFGTGGWDTDFPNSILEILRVVYTEADDHHRGIVGGSQQLPLRLWEREPGKIVHWPQGTSLSSLHGGEPRPAVTRLHRAAGDRVVVTDASGDIRSYQAVVFTAQSWMLLSKIDCADSLFPIDHWTAIERTHYMESSKLFVPVDRPFWLDKDEVTGRDTMSMTLTDRMTRGTYLLDDGPDRPAVICLSYTWCDDSLKWLPLSANERMEVMLKSLSEIYPNVDIRKHIIGSPVTVSWENEPYFMGAFKANLPGHYRYQRRLFTHFMQDRLPADKGGIFLAGDDISWTAGWAEGAIQTALNAVWGVMHRFGGATDPKNPGPGDLYDEIAPVELPED
>NC_015957.1|WP_043238697.1|3197702_3198395_-|hypothetical-protein
MPTHARPAPRTVQSVVARMSALGAALPPRDGVAVFNGVYLSVTEEVGRRLTDGYFHDPSATEELDVRFAGRYLAAVDTVVTGGRPPACWRPLFQLRRHPAVRPVQFALAGINAHIGHDLALALLDTCRARDLEPEALEGDFDRIGALLTGMEERIREELMPGPDLLDVADPLTHLVGSWSLEKARDAAWAAFRALWGLRGVPELAEEFAERVDTTVGLVGRFLLTPLPAA
>NC_015957.1|WP_014056290.1|3198489_3199374_-|NAD(P)-dependent-oxidoreductase
MPLILVTGATGQVGRRFTKRLLERPAAGTEVRVLVRDEERGAPFAAQGAQLTVGDLREEKDLRRAMEGVHAVVNIAAAFRGVPDEEAWAVNRDAAVALGRAAVEAGTSRFLQVSTNLVYGASRGRPFTEDDESVPGGLLWGAYPASKAEAERELLALHREHGLDLRIGSLAFVYGDGDPHVANFLPYAANWAGSKRLAMVHHADVIQALLRLLRAPGGTAGGSVSGRKYNIVDDAPATAVELHQLSGAPLPEGMTGRTDDDPWSGITSNLRLRDELGWRPLYPSIWTARDAGVL
>NC_015957.1|WP_014056291.1|3199503_3200361_+|helix-turn-helix-domain-containing-protein
MHRSELADFLRRCRARIGPAEVGLTPGPRRRTPGLRREEVAQLAGMSPDYYTRLEQARGPRPSRQMLTALARALRLTDDERDYLFHLVGEEPPRDRSTSEHVRPGLLRVLDRLYDTPAQVITDWGEVLAQNAMAAALVGDITARPVGDRNIVRSFFTRPDDASGAPGIFPSEEIEEHARLHVANLRAVLAARPDAPGPAALVAELLSVSPEFAALWEAHEVAVRHSSVKRFIHPVVGAMELDCEVLLSSEHAQRLIVHTARPGSESAERLELLRVLGLQDLAPRG
>NC_015957.1|WP_014056292.1|3200397_3201780_-|nitrate-reductase
MGLGVRWTLHGDGRTPAPGAVVRPDERLSWPRTAGLGAQHVVAMFGASFVAPVLMGLDPNLAIMMSGVATILFLLATRGRIPSYLGCSLSFVGVAAAIRAQGGGSAAVTGAILVVGGVLLLSGLAVRKFGARIIHTAMPPVVTGAVVMLIGFNLAPVTAGTYWPADQWTALLTMLLTGAAVVCLRGFWSRIAIFLGLVFGYAVSWVFDRVFGRIHSMDGSGRVTDHWRLDLSGVGKADWIGLPSLHAPSFHWSAVLVALPVVIALIAENAGHVKAVGEMIGDPLDDQLGTAIAADGAATMISTSVGGPANTTYSENIGVMAATRVYSTAAYWAAAGFALLFGLCPKFGAVVAAVPGGVLGGITVILYGMIGLLGAQIWVHNKVDLRNPLNLVPVAAGVIIGVGGVSLKIGQNFELGGIALGTIVVLLGYHVLGALAPAHLKPQEPLLDAGTSGYDDDRPA
>NC_015957.1|WP_014056293.1|3201849_3202737_-|isocitrate-lyase/phosphoenolpyruvate-mutase-family-protein
MSDKSDAPASDRHTAFRRLHHGDRPLLLPNAWDHASAAALVRRGFPAIGTTSLGVAAAAGLPDATGAARDETLALARGIARLPALVSVDIEGGFGERPEEVAALVAELDRAGVVGVNIEDGRPDGTLAPLAHQCAVLAAVKERVPRLFVNARTDAHWLAAIGGGAPPSLSAAAERIEAYVQAGADGIFVPALTDEYDIGALADDLGETPLNILFTPGRHSYERLAELGVRRISCGSLLFRAALDRAVELAWTIAHPDAPAPAHQAADLPSYAEAQSLAEDFTDDFTKDVTESTPT
>NC_015957.1|WP_014056294.1|3202823_3204056_-|MFS-transporter
MGRLKESGASEMRPVRRARIAVAAVFAVHGAVTGNFATRIPWIQERLDLSAGQLGLALAFPAIGASVAMPLAGRISHRFGARAALRGLLALWTAWLVMPPLAPGLVWLCGALFVFGATAGTSDVAMNALGVEVENRLGRSIMSGLHGMWSAGALIGSAAGTIAAHAEADARLHLAIAAGVLTVLGAVACHWVLDLRSAPEEHPPPRFALPPRSALIIGAVGFCAVFAEGASLDWSAVYLRDVMDSSPGIAAACTTAFSCMMAGARLIGDAVVGRFGPVRTVRTGGLLATAGGILVVTAPGAALAIAGFGLIGLGIAVVVPLAFAAAGRSGPAPSQAIAGVATITYTSGLIAPAAMGSIADLTSLTISFCLVTTLTLGLVAGAGVLRTPTETDAADPASHPDPSASRATLP
>NC_015957.1|WP_014056295.1|3204168_3205395_+|ROK-family-transcriptional-regulator
MTSTSVSVAGRTASPSTARAINDRLALQLLKDEGPLTAGQLKSLTGLSRPTIADLVERLRQTGLVAVVGEAGAERRGPNARVYGIVAESAHVAGVDVRTDSVAVCVADLLGRTKAEESLPVAPDGDSARTVAAAVALVERTAERAGAARLHHIGIGVPGLIDPATGELNSTGGLPSWHRELATALHADLAAPVLLENEVNLAAVAEQRMGTVRDRDTFVLLWLGHGIGAAVVLDRVLRRGASGGTGEIGFLPVPGTSGLPSATGCDGGFHSLVSSGAVCELAQEHGLEAAAGGERGEGAEGSGAAEAAIRAALDAGERGEAFLDALAARIALGVAAICAVLDPGCAVLGGEVGRAGGDGLARRVEDHAARLSPLRTRVRAGVVGGGGVLRGAVLTALDAAQNELFGAP
>NC_015957.1|WP_014056296.1|3205927_3207232_+|alginate-lyase-family-protein
MGAPPAGRGRFARAIVTASALLAVLAVSAAPSAQGAEPARHAGSVPRTVVLDGPRLSLTKLKLQLGDRNLRRTVRDLTAQADQWMEQGPWTVTDKDQAPPSGDKHDYFSQAPYWWPSRPKTDDNPYGCPYVQKDGQRNPDVDKMTDRPEVGKVFESAYELSLAWYYTGKRAYAEHAADILRTWFVTPATRMNPSLNHAQFIPCMYDGRSIGIIDFSQGFTSLLDAAALLDTGAPGWSKSDHEGFRTWNKQFLDWLVNSDFGKEEGAAENNHGTFYDMQVAAIATAVGDRDRARQVLRDARTKRIDTQIAADGTQPQELERTRSFHYSTFNLVAYTRMAAIGKHVGVDLWHYTGPGGANLFKAVDVLLPAATGAAPWPYPELDLRAYAASDIVHAAADAGDRKARAAVDKLQAPPGGDLWALRPAVEQLDSIAQG

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Crispr_ID: NC_015957_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015957_12

3827864-3827948

Orphan

Consensus_repeat	Method
CAGGTCAGGGAGAAGGTCGTCGACA	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NC_015957_12

>merge|NC_015957|12|3827864-3827948|CRISPRCasFinder
CAGGTCAGGGAGAAGGTCGTCGACACGGCCAAGGACCAGGTCAAGGACCAAGTCAAGGGCCAGGTCAAGGAGAAGGTCGTCGACA

>NC_015957|12|11|3827864-3827948|CRISPRCasFinder
CAGGTCAGGGAGAAGGTCGTCGACA	CGGCCAAGGACCAGGTCAAGGACCAAGTCAAGGGC
CAGGTCAAGGAGAAGGTCGTCGACA

Protein	Signature genes	Signature genes Name	Protein_function
NC_015957.1\|WP_014056808.1\|3821814_3823089_-\|FAD-binding-protein	unknown	unknown	gnl\|CDD\|130740
NC_015957.1\|WP_014056812.1\|3827144_3827666_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237171
NC_015957.1\|WP_078505256.1\|3820934_3821312_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NC_015957.1\|WP_043236023.1\|3821432_3821633_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235379
NC_015957.1\|WP_014056815.1\|3829200_3829986_+\|GvpL/GvpF-family-gas-vesicle-protein	unknown	unknown	gnl\|CDD\|377652
NC_015957.1\|WP_014056810.1\|3824195_3825713_+\|glycerol-kinase-GlpK	unknown	unknown	gnl\|CDD\|234594
NC_015957.1\|WP_014056807.1\|3820329_3820932_-\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|341362
NC_015957.1\|WP_014056818.1\|3830665_3831046_+\|gas-vesicle-protein	unknown	unknown	gnl\|CDD\|376379
NC_015957.1\|WP_014056806.1\|3819430_3820333_-\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NC_015957.1\|WP_014056809.1\|3823302_3824157_+\|aquaporin-family-protein	unknown	unknown	gnl\|CDD\|223653
NC_015957.1\|WP_050993959.1\|3833599_3835432_-\|CocE/NonD-family-hydrolase	unknown	unknown	gnl\|CDD\|225487
NC_015957.1\|WP_014056819.1\|3831042_3831879_+\|GvpL/GvpF-family-gas-vesicle-protein	unknown	unknown	gnl\|CDD\|377652
NC_015957.1\|WP_014056805.1\|3817918_3818773_-\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NC_015957.1\|WP_014056814.1\|3828748_3829201_+\|gas-vesicle-structural-protein-GvpA	unknown	unknown	gnl\|CDD\|236485
NC_015957.1\|WP_014056811.1\|3825852_3826998_+\|alcohol-dehydrogenase-catalytic-domain-containing-protein	unknown	unknown	gnl\|CDD\|176242
NC_015957.1\|WP_014056816.1\|3829988_3830240_+\|gas-vesicle-protein-GvpG	unknown	unknown	gnl\|CDD\|310007
NC_015957.1\|WP_014056822.1\|3832486_3833578_+\|helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|197713
NC_015957.1\|WP_014056821.1\|3832077_3832377_+\|gas-vesicle-protein-K	unknown	unknown	gnl\|CDD\|377462
NC_015957.1\|WP_014056817.1\|3830243_3830669_+\|gas-vesicle-protein	unknown	unknown	gnl\|CDD\|368618
NC_015957.1\|WP_014056820.1\|3831875_3832088_+\|gas-vesicle-protein	unknown	unknown	gnl\|CDD\|376379

Protein	Function_ID	Function_description	E-value
NC_015957.1\|WP_014056808.1\|3821814_3823089_-\|FAD-binding-protein	gnl\|CDD\|130740	TIGR01679, bact_FAD_ox, FAD-linked oxidoreductase. This model represents a family of bacterial oxidoreductases with covalently linked FAD, closely related to two different eukaryotic oxidases, L-gulonolactone oxidase (EC 1.1.3.8) from rat and D-arabinono-1,4-lactone oxidase (EC 1.1.3.37) from Saccharomyces cerevisiae.	2.55184e-44
NC_015957.1\|WP_014056812.1\|3827144_3827666_+\|hypothetical-protein	gnl\|CDD\|237171	PRK12678, PRK12678, transcription termination factor Rho; Provisional.	0.000554357
NC_015957.1\|WP_078505256.1\|3820934_3821312_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	1.82668e-08
NC_015957.1\|WP_043236023.1\|3821432_3821633_+\|hypothetical-protein	gnl\|CDD\|235379	PRK05261, PRK05261, phosphoketolase.	5.53917e-13
NC_015957.1\|WP_014056815.1\|3829200_3829986_+\|GvpL/GvpF-family-gas-vesicle-protein	gnl\|CDD\|377652	pfam06386, GvpL_GvpF, Gas vesicle synthesis protein GvpL/GvpF. This family consists of several bacterial and archaeal gas vesicle synthesis protein (GvpL/GvpF) sequences. The exact function of this family is unknown.	1.45077e-67
NC_015957.1\|WP_014056810.1\|3824195_3825713_+\|glycerol-kinase-GlpK	gnl\|CDD\|234594	PRK00047, glpK, glycerol kinase GlpK.	0
NC_015957.1\|WP_014056807.1\|3820329_3820932_-\|CBS-domain-containing-protein	gnl\|CDD\|341362	cd04586, CBS_pair_BON_assoc, Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection proteins. It is also found in some secretins and a group of potential haemolysins. Its likely function is attachment to phospholipid membranes. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).	3.56291e-33
NC_015957.1\|WP_014056818.1\|3830665_3831046_+\|gas-vesicle-protein	gnl\|CDD\|376379	pfam00741, Gas_vesicle, Gas vesicle protein.	1.663e-14
NC_015957.1\|WP_014056806.1\|3819430_3820333_-\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	5.13373e-19
NC_015957.1\|WP_014056809.1\|3823302_3824157_+\|aquaporin-family-protein	gnl\|CDD\|223653	COG0580, GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism].	3.25442e-70
NC_015957.1\|WP_050993959.1\|3833599_3835432_-\|CocE/NonD-family-hydrolase	gnl\|CDD\|225487	COG2936, COG2936, Predicted acyl esterases [General function prediction only].	4.10143e-118
NC_015957.1\|WP_014056819.1\|3831042_3831879_+\|GvpL/GvpF-family-gas-vesicle-protein	gnl\|CDD\|377652	pfam06386, GvpL_GvpF, Gas vesicle synthesis protein GvpL/GvpF. This family consists of several bacterial and archaeal gas vesicle synthesis protein (GvpL/GvpF) sequences. The exact function of this family is unknown.	1.86897e-65
NC_015957.1\|WP_014056805.1\|3817918_3818773_-\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	1.10742e-17
NC_015957.1\|WP_014056814.1\|3828748_3829201_+\|gas-vesicle-structural-protein-GvpA	gnl\|CDD\|236485	PRK09368, PRK09368, gas vesicle structural protein GvpA.	2.23078e-46
NC_015957.1\|WP_014056811.1\|3825852_3826998_+\|alcohol-dehydrogenase-catalytic-domain-containing-protein	gnl\|CDD\|176242	cd08282, PFDH_like, Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH). Formaldehyde dehydrogenase (FDH) is a member of the zinc-dependent/medium chain alcohol dehydrogenase family. Unlike typical FDH, Pseudomonas putida aldehyde-dismutating FDH (PFDH) is glutathione-independent. PFDH converts 2 molecules of aldehydes to corresponding carboxylic acid and alcohol. MDH family uses NAD(H) as a cofactor in the interconversion of alcohols and aldehydes, or ketones. Like the zinc-dependent alcohol dehydrogenases (ADH) of the medium chain alcohol dehydrogenase/reductase family (MDR), these tetrameric FDHs have a catalytic zinc that resides between the catalytic and NAD(H)binding domains and a structural zinc in a lobe of the catalytic domain. Unlike ADH, where NAD(P)(H) acts as a cofactor, NADH in FDH is a tightly bound redox cofactor (similar to nicotinamide proteins). The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of an beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit.	0
NC_015957.1\|WP_014056816.1\|3829988_3830240_+\|gas-vesicle-protein-GvpG	gnl\|CDD\|310007	pfam05120, GvpG, Gas vesicle protein G. These proteins are involved in the formation of gas vesicles.	3.73531e-14
NC_015957.1\|WP_014056822.1\|3832486_3833578_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197713	smart00418, HTH_ARSR, helix_turn_helix, Arsenical Resistance Operon Repressor.	1.79575e-11
NC_015957.1\|WP_014056821.1\|3832077_3832377_+\|gas-vesicle-protein-K	gnl\|CDD\|377462	pfam05121, GvpK, Gas vesicle protein K. These proteins are involved in the formation of gas vesicles.	5.78723e-32
NC_015957.1\|WP_014056817.1\|3830243_3830669_+\|gas-vesicle-protein	gnl\|CDD\|368618	pfam05800, GvpO, Gas vesicle synthesis protein GvpO. This family consists of archaeal GvpO proteins which are required for gas vesicle synthesis. The family also contains two related sequences from Streptomyces coelicolor.	4.97754e-28
NC_015957.1\|WP_014056820.1\|3831875_3832088_+\|gas-vesicle-protein	gnl\|CDD\|376379	pfam00741, Gas_vesicle, Gas vesicle protein.	5.86027e-10

>NC_015957.1|WP_014056812.1|3827144_3827666_+|hypothetical-protein
MKNCRVALAFASGYLFGRGHRGALVLGLAGIAAGKRLSSGISPPGAQQLKSSQFGRLGQEIGGRLVTAGREAAMSAASRRMDALSDRLEQRASTLRTGGTEGGEPEAGEHEEPDGHEEREEHEEREERERGGAARSREGEPRERGKQQRKPADRPAQARKRTGSEGPARRSQR
>NC_015957.1|WP_014056811.1|3825852_3826998_+|alcohol-dehydrogenase-catalytic-domain-containing-protein
MKAVVYEKPYSVAVRDVDDPRIEHPNDVIVRVTSSAICGSDLHMYEGRTAAEPGIVFGHENLGVVEETGPGVVALSKGDRVVMPFNVACGFCKNCLAGDTGFCLTVNPGFAGGAYGYVAMGPYPGGQAERLRVPFADFNCLKLPAGEEFETDFVLLADIFPTGYHGCELAEVSPGESVAVYGAGPVGLMSAYSALLRGAAKVFVVDRVLERLAKAEEIGAIPIDFSKDDAVRQILDRTGGEGTDKGIDAVGYQAQGREAGHEEPAVVLNSLVDTVRPTGRLGVPGLYVPSDPGAPDEHAKRGQLLVSIGRMFEKGQRMGTGQCNVKRYNRQLRDLIIAGRARPSFVVSHELPLDQAPQAYEKFDKRVEGYTKVVLHPALAA
>NC_015957.1|WP_014056810.1|3824195_3825713_+|glycerol-kinase-GlpK
MPEFVGAVDQGTTSTRFMIFNHDGDEVARYQLEHRQILPRAGWVEHDPVEIYERTNSVMQNALREGGLTADDLAAMGITNQRETTVIWDPRNGRPYYNAIVWQDTRTDTIAAALERDGRGEIIRRKAGLPPATYFSGGKIKWILENVEGVREAAERGHALFGNTDAWVLWNLTGGPGAGVHATDVTNASRTMLMNLETLDWDDELLEIFGIPRAMLPTINPSSHPEAFGQARTSRPLRTATPITGVLGDQQAATVGQVCFAPGEAKNTYGTGNFLLLNTGAELIRSTSGLLTTVAYQFGDSPPVYALEGSIAVTGSAVQWLRDQMKMIDEASGSERLARTVEDNGGVYFVPAFSGLFAPYWRSDARGAIVGLTRYNTNGHIARATLEAICYQSRDVVEAMERDADIHLDVLRVDGGVTDNELCMQIQADVLGVPVSRPVIAETTALGAAYAAGLATGFWRDTDELRSHWSESRRWEPQWDQKAREEGYAGWKKAVQRTLDWITVE
>NC_015957.1|WP_014056809.1|3823302_3824157_+|aquaporin-family-protein
MTDPKAAPEANRPRSALIGELCAEFVGTMVLILFGCGVVAQVVAGGDLTKPPGGLGDHDSIAWGWGLGVTLGVYVAARLSGAHINPAVTVSLAAFKGFPWSKVLPYVAAQTLGAFVGALLVRWNYTEVLGHADPGHTFKTQFVFSTLPGNGALPVSEWGALRDQIIGTAILVLLIFAVTDLLNSAPRANLGPLIIGLIVVAIGMAWGADAGYAINPARDFGPRLASYLTGYHSAWRDQYGDIYFWVPIVGPLVGGLIGAALYKVLITRYLPVAGPEVGRTPTPE
>NC_015957.1|WP_014056808.1|3821814_3823089_-|FAD-binding-protein
MPTTHAPTNWAGNITFSAARLHHPDTVDELRRIVRSADRVRVLGTGHSFNRIADTEGDLVNLDRLPHRVEIDPGKRTATIAAGMRYAHVAQALHTEGLALANLASLPHITVAGACATATHGSGSAQQCLAAAVAGLEIVGPDGEVTRIGRDEDRDRLNGAVVGLGGLGVVTAMTLDIEPTYDVAQWVWTGLPLDRLDDSFEEIFGAAYSVSVFTDWRSGEGVVWLKCRTDLPDPPEPGQPWLGAVPADRHHHHPVPAMPPLHCTEQLGAPGPWHERLPHFRPDFTPSNGDELQSELLLPREAASAAFAALRGLGDRIAPVVQVSEVRTVAADELWLSPAYGRDSVAFHFTWVPDHEAVIEVVAAMEEALLPLGARPHWGKLTTAAPERILSSYDRAADFARLLAEHDPAGKFRNAYLDGYFPTG
>NC_015957.1|WP_043236023.1|3821432_3821633_+|hypothetical-protein
MPDAPTTTGSPDSSTGSPESSTGSPDSGLGDNRIRALDAHWRAANYLAAGQIYLLANPLLWTASGW
>NC_015957.1|WP_078505256.1|3820934_3821312_+|universal-stress-protein
MPPRSGPSFGRRPGRPLGLPGVRCGPFGPHGRPGPNDPRRGRSAPRAVDHALRTPGRDHPEVTVHRATVEGTARKALLHAAATADLLVLGARRGRGHAVGLELGRIAHAALHHAPCPVVIVPERV
>NC_015957.1|WP_014056807.1|3820329_3820932_-|CBS-domain-containing-protein
MKHRKIGNVMTDDVVRVSSMTSFDEVGALLSRHRFNGLPVVDDDDKVVGMITGTDLSEPAPTAGQLMSRPAVTVRPQDSIVDAARAMDRHRVERLPVVDEEERLIGIVTRRDLLRVFLRPDDEIRAEVIDEVLVRSLWLGPQSVAVTVTDGIVRLEGQLDRHSEIPIAVRMTGQVDGVVAVVDRLTYLIDDSAGRGGARR
>NC_015957.1|WP_014056806.1|3819430_3820333_-|universal-stress-protein
MTHPAKPVRDGRVVVGLDGSDSAWAALDGAVAEARRRHAKLEIVHAWPWARTDPLAFDPDSEPRRPAVEIARTVLRLAVSRAQEQDPQLRIVPTLTAQDAVPELLRIGGDAALIVIGTRGLGGFTGLLLGSVGLRLAAHTRRPLLVVRGGPTTTYGPESHGKVLVGVESGADAAAARFAFEEAKRRRAWLRVLYAWPRPRVFAGDHALPAREVVALRAEREQTVAYGMVAGLREEFGQIRVREHTTHTAPAQALVEASRAADVLILAVHRRTPRLGMQLGPVTHAALHHAHCPVVLVPVE
>NC_015957.1|WP_014056805.1|3817918_3818773_-|universal-stress-protein
MARPVTVGLDGSPESLAAAGWAAHEARSRDAPLRLVNAWPGPDQKDLTPGREAAWHYWAERALGSARAELDADHPDMAILTDQIPGRPAPVLLAEAERAQLLVVGSRSIGAVAGFFLGSVGLELAARAVTPVVLVRADAHEDRQGDVVVGVEPGEPGDDILEFAFDAAARRDGVLRAVYASRVPAIRGDAPWVVDVGLSDARKESEHALGEVLAPWRDKFSEVRVFEEIASDSPARQLVGVAAGTALMIVGRGPRHVGFGPRLGPVTQAVAHHAACPVAIVPQR
>NC_015957.1|WP_014056814.1|3828748_3829201_+|gas-vesicle-structural-protein-GvpA
MTVARQQQSQYLDRASSSALVDVVDLILDKGLVIDVYVRVSLVGIELLTIDARIVVASVDTYLRFAEATNRLDLARSGTETHGLPGLMDDLREGGGKKKTKGALEGVKESVSDLLQDDADDADEDREPEPEERGRPRRTRGSTSHRERER
>NC_015957.1|WP_014056815.1|3829200_3829986_+|GvpL/GvpF-family-gas-vesicle-protein
MAEDGRACYVYGVVTDDRTDEAVKDLPAVGDPEAPVTLVRHRGQAAVVSEVPVGKPLGTPEDLRTHAKVLDSLAEQGPPVLPFRFGTVVRDTAAVTDELLAEGHDDFARGLDRLRGRSQLTVRARYEQDAVLREVVTEQPEARRLREELRGLPEEEGYEQRIQLGRLVLDTIEAKRSVDALELDRRLGPYALGSVSQEAASAEGLVNASFLVEDAKRQAFEEAAEELAELWHGRVRLRLLGPLAPYDFVADALLEGEEGEE
>NC_015957.1|WP_014056816.1|3829988_3830240_+|gas-vesicle-protein-GvpG
MGLFTGLVTLPLAPVRGVVWVAERLHDEAHRQLYDPEVIKQRLEEVAEARESGELTEEEAAREEDELVRRLMSQGPPGGGMEV
>NC_015957.1|WP_014056817.1|3830243_3830669_+|gas-vesicle-protein
MPPEERPREERRREARHDEDRHRDDRHHEERPRTRPREERDRHEQGHEREWPRRSALDARGAARSAARHVEGLTGRAAEGVTSLERGEDGWIIGIEVVETHRIPDSTDILAEYQVELDDTGELSSYRRTERYYRGRREDRT
>NC_015957.1|WP_014056818.1|3830665_3831046_+|gas-vesicle-protein
MNQSSDWNAPVRRTGGAREPARRGSEPSSLADILERVLDKGIVIAGDIQINLLDIELLTIKIRLLVASVDRAKEMGIDWWEHDPTLSSGARDVLEENERLRRRVGELEDGPGAREVDRGAEREDER
>NC_015957.1|WP_014056819.1|3831042_3831879_+|GvpL/GvpF-family-gas-vesicle-protein
MTDSLATWLYAVTAAPEDGAPPQGLTGVADEPVRLVEKAGLAAVVGSVPLEEFDEDALRGHLEDLEWLERTARAHHRVINGAARQGQVIPLRFATLYHDDDRVRAMLQERREDFTATLRRVAGRTEWGVKAYVDPRSFLPDPDEPAGGEDSPGTAYLLRRRAQRQDQETAHLRATERAAGIHASLAALAGATAAHPPQDTALAKYEGWMVLNNSYLVPDGLTEEFTALVITLGERYPGVTLEVSGPWPPYSFTAPPKREGQEGEEGQEGEARPEEAPS
>NC_015957.1|WP_014056820.1|3831875_3832088_+|gas-vesicle-protein
MTRAIERREVALVDLLDRVLAGGVVIAGEITLTIADIDLVRISLRALIASVRVENEEEERGGREGVRHDG
>NC_015957.1|WP_014056821.1|3832077_3832377_+|gas-vesicle-protein-K
MTDDRAPRPGRRIEVDEESVRKSLAGLVLTIVELLRQLMERQALRRVEQGGISDEQIEKLGLTLMALEQNMAELREHFGLTEDDLNLDLGPLGPLLPRD
>NC_015957.1|WP_014056822.1|3832486_3833578_+|helix-turn-helix-transcriptional-regulator
MGITLNLQRARPADVYVGRSALAELMSVLHIMAEPDHHPEAQRWTHRLGTAISPSLAHEMSALSPLWARLRCRLLFPLGLPLDQPFEDELRHLEKLPLEEFVGLCSQGVLGFREAVPPARSLLTDPGAAERYVAQCELRSIRRGELAHDLVASPEGLRGRLLCFLDSCAEAFFASEWRTVRDRLESAAARVRSDIRRRGLAEVLAGLSPTAVVSRGGERVRYDKLAVAEIEIGPRPLFLLPSVHVWPHLTVKDEESHPVVLQFAAQEDRTADQLTQAELRARMSALASLGRMEVCRHLLGEPITTSELAQRMGLADTQVSRTLRQLRDAGLIESEREGKYVYHRLATTTLLRLGQDVLATIMR
>NC_015957.1|WP_050993959.1|3833599_3835432_-|CocE/NonD-family-hydrolase
MLDERVWRRTLRVPMRDGVVLAADLFSAEERPGPRPVILERTPYGRRDLRDSDRSRHDEPVPTPEETSALFVRAGYHVVRQDCRGRGDSDGTFVKYLGEGPDGADTIDWIAAQPWCDGRVAMMGVSYSAHAQTAAAAESPTGLSAMFMDSGGFASAYEAGMRMGGAFELKQITWAFRHGEESPEAERDPLVRKAFAGTDLRDWFTVLPWRTGVSPLRQVGSYERYLLDQWRHDAFGAYWRQPAIYGRGHYDRFPDVPTLHMSSWYDPYVRSTIENFTAMGRLKRSPAYLVMGPWKHGLRCVTFAGDVDFGPAATFSGNVDTSYLSFRQRWFDAVLGGGDPESIPRVRYFLMGGGDGRRDEAGRMRHGGRWHTDTRWPPAGTRETAFYCHTSGELSRERPAAERGWVEYDFDPNDPVPTLGGQVTSGEPVMVGGAFDQVPDERFYGARPPYLPLNSRPDVISLATPPLEEPLVVAGPVTARLFISSSAPDTDFTVKLVDVYPPNEDYPHGFAMNLTEGIFRCRFHESFERPEPLEPGEVYEIEIPAPDTANRFEAGHRLRVDISSSDFPRFDVNSNTGVPEAVSRRKVVATNRVHMDADRPSAVLLWTQPG

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Crispr_ID: NC_015957_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015957_13

4082401-4082488

Orphan

Consensus_repeat	Method
GCGGCTGACGCCCGCCCGTGGGCGACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015957_13

>merge|NC_015957|13|4082401-4082488|CRISPRCasFinder
GCGGCTGACGCCCGCCCGTGGGCGACCACGGTCCAGGGCCATCGGGAGCTCCACCGGTGATGCGGCTGACGCCCGCCCGTGGGCGACC

>NC_015957|13|12|4082401-4082488|CRISPRCasFinder
GCGGCTGACGCCCGCCCGTGGGCGACC	ACGGTCCAGGGCCATCGGGAGCTCCACCGGTGAT
GCGGCTGACGCCCGCCCGTGGGCGACC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015957.1\|WP_043236071.1\|4071983_4072769_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|236110
NC_015957.1\|WP_014057005.1\|4086200_4088141_-\|glycosyl-transferase	unknown	unknown	gnl\|CDD\|273955
NC_015957.1\|WP_014057007.1\|4089549_4090323_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_015957.1\|WP_014056993.1\|4074919_4075342_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223868
NC_015957.1\|WP_014056992.1\|4073490_4074648_+\|acetyl-CoA-C-acetyltransferase	unknown	unknown	gnl\|CDD\|181123
NC_015957.1\|WP_014056999.1\|4080390_4081536_-\|serine/threonine-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272
NC_015957.1\|WP_014057002.1\|4083498_4084095_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274357
NC_015957.1\|WP_014057004.1\|4085860_4086214_+\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_106685900.1\|4076056_4076950_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372724
NC_015957.1\|WP_014057003.1\|4084199_4085864_+\|cytochrome-c-oxidase-subunit-I	unknown	unknown	gnl\|CDD\|238832
NC_015957.1\|WP_014057008.1\|4090319_4091102_-\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014057006.1\|4088279_4089548_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NC_015957.1\|WP_043239043.1\|4091248_4091824_-\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|365939
NC_015957.1\|WP_050993680.1\|4092171_4092636_-\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014057001.1\|4082521_4083502_-\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014056998.1\|4078981_4079827_-\|glutathione-S-transferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|223512
NC_015957.1\|WP_014056996.1\|4077194_4078055_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377085
NC_015957.1\|WP_043239032.1\|4078197_4078941_+\|Mut7-C-ubiquitin/RNAse-domain-containing-protein	unknown	unknown	gnl\|CDD\|376668
NC_015957.1\|WP_014056994.1\|4075355_4076051_+\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_043239029.1\|4072853_4073456_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380061

Protein	Function_ID	Function_description	E-value
NC_015957.1\|WP_043236071.1\|4071983_4072769_+\|SDR-family-oxidoreductase	gnl\|CDD\|236110	PRK07831, PRK07831, SDR family oxidoreductase.	2.67718e-156
NC_015957.1\|WP_014057005.1\|4086200_4088141_-\|glycosyl-transferase	gnl\|CDD\|273955	TIGR02074, Includes:_Penicillin-insensitive_transglycosylase, penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	6.37707e-108
NC_015957.1\|WP_014057007.1\|4089549_4090323_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	6.7091e-75
NC_015957.1\|WP_014056993.1\|4074919_4075342_+\|hypothetical-protein	gnl\|CDD\|223868	COG0797, RlpA, Lipoproteins [Cell envelope biogenesis, outer membrane].	2.31527e-06
NC_015957.1\|WP_014056992.1\|4073490_4074648_+\|acetyl-CoA-C-acetyltransferase	gnl\|CDD\|181123	PRK07801, PRK07801, acetyl-CoA C-acetyltransferase.	0
NC_015957.1\|WP_014056999.1\|4080390_4081536_-\|serine/threonine-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	1.56466e-37
NC_015957.1\|WP_014057002.1\|4083498_4084095_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	7.14356e-21
NC_015957.1\|WP_106685900.1\|4076056_4076950_+\|hypothetical-protein	gnl\|CDD\|372724	pfam13779, DUF4175, Domain of unknown function (DUF4175).	0.0089469
NC_015957.1\|WP_014057003.1\|4084199_4085864_+\|cytochrome-c-oxidase-subunit-I	gnl\|CDD\|238832	cd01662, Ubiquinol_Oxidase_I, Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits in ubiquinol oxidase varies from two to five. Subunit I contains a heme-copper binuclear center (the active site where O2 is reduced to water) formed by a high-spin heme and a copper ion. It also contains a low-spin heme, believed to participate in the transfer of electrons from ubiquinol to the binuclear center. For every reduction of an O2 molecule, eight protons are taken from the inside aqueous compartment and four electrons are taken from ubiquinol on the opposite side of the membrane. The four electrons and four of the protons are used in the reduction of O2; the four remaining protons are pumped across the membrane. This charge separation of four charges contributes to the electrochemical gradient used for ATP synthesis. Two proton channels, the D-pathway and K-pathway, leading to the binuclear center have been identified in subunit I. It is generally believed that the channels contain water molecules that act as 'proton wires' to transfer the protons. A well-defined pathway for the transfer of pumped protons beyond the binuclear center has not been identified. Electrons are believed to be transferred directly from ubiquinol (the electron donor) to the low-spin heme, and directly from the low-spin heme to the binuclear center.	0
NC_015957.1\|WP_014057006.1\|4088279_4089548_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	4.48501e-39
NC_015957.1\|WP_043239043.1\|4091248_4091824_-\|PAS-domain-S-box-protein	gnl\|CDD\|365939	pfam00196, GerE, Bacterial regulatory proteins, luxR family.	2.96899e-10
NC_015957.1\|WP_014056998.1\|4078981_4079827_-\|glutathione-S-transferase-domain-containing-protein	gnl\|CDD\|223512	COG0435, ECM4, Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones].	5.52614e-26
NC_015957.1\|WP_014056996.1\|4077194_4078055_+\|hypothetical-protein	gnl\|CDD\|377085	pfam03631, Virul_fac_BrkB, Virulence factor BrkB. This family acts as a virulence factor. In Bordetella pertussis, BrkB is essential for resistance to complement-dependent killing by serum. This family was originally predicted to be ribonuclease BN, but this prediction has since been shown to be incorrect.	9.45999e-08
NC_015957.1\|WP_043239032.1\|4078197_4078941_+\|Mut7-C-ubiquitin/RNAse-domain-containing-protein	gnl\|CDD\|376668	pfam01927, Mut7-C, Mut7-C RNAse domain. RNAse domain of the PIN fold with an inserted Zinc Ribbon at the C-terminus.	7.74706e-58
NC_015957.1\|WP_043239029.1\|4072853_4073456_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|380061	pfam17932, TetR_C_24, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in family members such as HTH-type transcriptional repressor KstR2 as well as fatty acid metabolism regulator proteins. In Mycobacterium smegmatis, KstR2 is involved in involved in cholesterol catabolism, while YsiA in Bacillus subtilis is involved in fatty acid degradation.	5.59608e-20

>NC_015957.1|WP_014056999.1|4080390_4081536_-|serine/threonine-protein-phosphatase
MRFIRFAPGASGRSHTLFAVTRCLPFLVLAAVLSIELSPAHTLYTGPLLSPAPALAAVTMGPFGTGGVALLAMAVSAVTATHNNVWGSEMVYANLLALLVVALASVATSAVRVRRDRELAQIRRIAEVSQNVVLRPLPARIGVVNTASVYMAAERGAQIGGDLYEAMCTRYGVRLIVGDVRGKGLAAVRSAAAVVGAFREAVHYEQDLAEVMHRCAAALAREYELLDRSQLQDPQELEEQFVTVLLAQVSDESLVELINRGHPPPLVMRERKVRSLDPARPLPPLGLEEFLSPPPICVESFPFLPGDRLLLHTDGVVEARNHYDEFFPLHRTMETLDGDTPGEYLDRLRHALVRHAEGRLADDAAMVLIERAIGGARRPFL
>NC_015957.1|WP_014056998.1|4078981_4079827_-|glutathione-S-transferase-domain-containing-protein
MSETFPVSSGPAALLDPDPCTTRPRIAPPAPPHRFRSRIGVDLAGGFYPVPHRYRLYLSASCPLSLRVSITLDLLGLRDTVATTLVGPPADTPEAFAALRGAYEATWHRYGGPLDAPALCDGWTGRVVSNHTPDILRDLAGHLSDGGGTGRPRLRPAPRAADIDALRELLDDDITHAARQAGTAHEPECRDAALERLLTALGRLDRRLAAAPYALGDELTAADVDLWVALVQLDTEHRLRLDADAAQRVSRHGRLRAYVRRLHAHPAFHTTIPEALQDDVS
>NC_015957.1|WP_043239032.1|4078197_4078941_+|Mut7-C-ubiquitin/RNAse-domain-containing-protein
MNGPEIHLSLAPELRFFAVPERRRPWTAVVTDGASTLGHVVESLGVPLTEVGRLVVNGEETAVSHVPSAGETVEVHPVVRPQRVPGAPLRFLLDVHLGTLARRLRLLGVDAAYESEDIGDPELAARSAAQRRVLLSRDRGLLRRRELWAGAYVYSDRPDEQLRDVLGRFTPSLAPWTRCTACNGTLEDADKESVRELLQHGTRRTYEVFARCTVCERVYWRGAHHARLEAIVAGAMDEFGDARAALS
>NC_015957.1|WP_014056996.1|4077194_4078055_+|hypothetical-protein
MSEHRSASGSRGPRWWRRLEDAFHRSAIGRGWRRGSDFELLHRAMGFAALGFLTLVPLLIVVAAADPVDRLGFAQWLAEGLGLSSTSRGEVQQLFAPPKQALESTTAFGLATLAVFSLRFGTVLQVGYEKVWELPAGRWHTAWRHLVWFVVLIGYLLLSAHLEPGISRVLVAVVGTVLFFWWSQRLLLGGRISWGALLPGALATGVGLLGLRVFSQLVFSPLIASNAVSYGPVGTVLVVQSWLVGVGYVVFGGALLGRVLYEEYLRMVAWRRKRRRDQAKAAPPAD
>NC_015957.1|WP_106685900.1|4076056_4076950_+|hypothetical-protein
MVCALAPLVLAGVLGPAGAGKLFGRGTARQAPRTALARLLRDGGRAALVLRALGAVELLLAAALLAPPATPLPGTAAALLGAGFLGYLGYARTAAPGSSCGCTARQDAPLTWRAFARAAAVLAGGVAAALAQQPWWTAAARRPVAALCLVLAAAAALTALSADPDRRWRMPLRRLRLRIAGHPLAATGHPLAATGHSLAATGAPAAVPVAATVELLERSRAWQSASRVVRSALLDHWDDGGWRILQFAGVHGGGTAARPVLVLFAVDAAASLDTVREPAVRVSVIDADSGDPVVATA
>NC_015957.1|WP_014056994.1|4075355_4076051_+|hypothetical-protein
MSAYRTGDPLDRRRFLTAAALRGATVIGTGALTTGALSAGVLGTGVIGATALGAVDADAAFAAPIRPLDPAVAESAFAEGRITAINHDVLEVAGSYGDHSRVRVTNATSVWKARATTAADIETGDGLYARGLPLPDGTLAADAVWVNIVNLHATIRGIEKTRLHLAHGQHEIVGNLMAQTTSASYGEASPTADLSRLTIGQSAQVLGAWRPSDGSVDLVRVAVAPGAGRRR
>NC_015957.1|WP_014056993.1|4074919_4075342_+|hypothetical-protein
MACGSTKLWNGEATWFCCGNAWGPCASAGGGACGTCRSSALQAAWPNASKACWDLTRPDLCGEDIPRRGCGSMMKVRHDCSGASVCVTVSDCGPRTRSFCSESTCCDGVCRTNRVIDLTPAAFSAIGSLSSGTLPVSIFE
>NC_015957.1|WP_014056992.1|4073490_4074648_+|acetyl-CoA-C-acetyltransferase
MPEAYIVEAVRTPVGRRKGGLASVHPADLGAHVLRTLMERSGADPAAVEDVVFGCLDTVGPQAGDIARTCWLAAGLPEEVPGVTVDRQCGSSQQALHFAAQAVLSGTQDLVVAGGVQNMSMVPIGFASRQAGEPLGLTEGPFAGSEGWRARYGDRPVSQFYGAELIAEKWGITREAMEEFALGSHQRALRAMDEGRFDREVVPFADVRMDEGPRRDTSLEKMAALKPLMEGGRVTAALSSQVSDGAAALLVASEQAVREHGLTPRARVHHLSVRGEDPIRMLSAPIPATAHALKKTGLTIDDIDLVEINEAFAPVVLAWLKETGADPERVNVNGGAIALGHPLGATGTKLMTTLLHELERTGGRYGLQTMCEGGGQANVTIVERL
>NC_015957.1|WP_043239029.1|4072853_4073456_+|TetR-family-transcriptional-regulator
MSPSPERRRELLSTAAEVFAAQGYNATTVRRIADEAGMLAGSLYYHFDSKESMVDEILSTFLDELWAGYEAVLGAGLGPRETVEALVTESFREIDRHRAAVAIYQKESRHLSAQPRFGYLTESQRRFERAWLGALERGVAEGVFRADLDIRLAYRFLRDTVWVAASWYRPGGQHSPEEIARQYLSMVLDGITPRERQERP
>NC_015957.1|WP_043236071.1|4071983_4072769_+|SDR-family-oxidoreductase
MDNKAPYVPGHGLLTGRTAVITAAAGAGIGGATARRFLEEGARVVLGDAHGRRLKETVAALAEEFGEERVAGCASDVTDEAQIAALYDLAEERHGRLDAVVNNAGLGGTALLTEMTDEQWDKVIDVTLNGTFRCTRAALRRMKAGGHGGVVVNNASVVGWRAQAGQAHYAAAKAGVMALTRCAAVEAAAYRVRVNAVSPSLAMHPHLVKVTTPELLAGLTEREAFGRYAEPWEVANVIVFLASGYSSYMTGETVSVSSQHA
>NC_015957.1|WP_014057001.1|4082521_4083502_-|hypothetical-protein
MTDELDLLREADPVSADTGPWRDRPLNARAELLLRRLPSQDRGRRTVRRVIWSLEAAAAATVLALALTVSGTPSSAVAASRPVPLVAHASGADVSLGEIVRRARTAAEESPGKSERGSHFQSWALSMKSGEDPVTLPRESLTRWNADGSGFSLEVATDPRHPGRPVIADGTPPRAVHDGKVLSEEKYPAGINGANESYFEDPPAGASALRAYLAVWSRGADRDPAELISAIESFLAVWTPGPRQRADIVTLLSRIEGLRPTGKVTDRLGREGQAFRFTPASSGMRYLIVLDPDDGSVLDVEETITRDDPEYKLKAGDVMSYKAWVS
>NC_015957.1|WP_014057002.1|4083498_4084095_-|sigma-70-family-RNA-polymerase-sigma-factor
MSTDDAFDAAYREHYWAVSRFVARRLDDQAWEVEEVVAEVFAVAWRRRTELPESPLPWLYGVARHCLANTVRGKGRYRRLLAKLGHHEVTRDGRTVASPDAERPGSWVLEALARLAEADQEVLRLTTWEELTVEELGTVLGCGRSAAAMRLHRARRRLREQIETLRRDDRVSVGCTSGKGDKAHSAGRADKAHKDGHA
>NC_015957.1|WP_014057003.1|4084199_4085864_+|cytochrome-c-oxidase-subunit-I
MRNNTVVAAAPAAPPSRRPGPGSTAVRWLTTTDHKTIGTLYLITSFAFFCIGGVMALLMRAELARPGLQIMSNEQFNQAFTMHGTIMLLMFATPLFAGFANWIMPLQIGAPDVAFPRLNMFAYWLYLFGSLIAVGGFLTPQGAADFGWFAYSPLSDAVRSPGVGADMWIMGLALSGFGTILGSVNFITTIICMRAPGMTMFRMPIFTWNVLLTGVLVLLAFPVLAAALFALEADRQFGAHVFDAANGGALLWQHLFWFFGHPEVYIIALPFFGIISEVIPVFSRKPMFGYISLIAATISIAGLSVTVWAHHMYVTGGVLLPFFSFMTFLIAVPTGIKFFNWIGTMWKGSLSFETPMLWATGFLITFVFGGLTGVILASPPMDFAVSDTYFVVAHFHYVIFGTVVFAMFAGFHFWWPKFTGKMLDERLGKITFWTLFLGFHGTFLVQHWLGAEGMLRRIPDYLAADGVTTLNTISTISSFVLGLSFLPFLYNVWKTAKYGEKVVTDDPWGYGRSLEWATSCPPPRHNFVSLPKIRSESPAFDLHHPDVGQKESVA
>NC_015957.1|WP_014057004.1|4085860_4086214_+|hypothetical-protein
MSMARAAEPPGIAAGINQIEGYLLLQTERDAARERARRLTAPLDWLTSAQRAEVERLYLQDQLAVTEQTLRKVVRRCEELRAEYQEVYRTLRRRLLLVCLLGAATLAGGFAAALTVR
>NC_015957.1|WP_014057005.1|4086200_4088141_-|glycosyl-transferase
MAGPLTALRERFTPDSKQAPRDTRPPSRQHGEKRHGKPKRTGIRRLFTWRKLIAYVAGLCALLIGAFTVLYYSIDVPKANAQAKAQSNVYKYSDGTILARTGEINREMVTLDRIPTGVQHAFVAAENKSFYKDRGVDPMGILRGVVNTVAGKGTQGGSTITQQYVKNYYLSQEQTASRKIKELVISLKVDQRNSKEDILAGYLNTSYFGRVAYGIQAAARAYYDKDVDDLTVEEGAYLAALVQAPSQYDWAVASPKAKRLVTRRWNYVLDNMVDMHWLDPAQRKHMRFPVPVDPKPAPGLDGQAGYLVDAARNELIASGVSEQELAAGGWTITLNVDPAKQRALEKTMRQGLDGSAKGKPRTDGSGEEKQTRADGSADEKQARADAAATQGGAVSVDPKNGRILALYGGRDYTRHYLSNATRGDYQVGSAFQPVTDAASMDAKMHNGPDAGGLPEIKRTARALGMDTDGGFGTKESVELGLMGSSPLKMAGVYASFNHQGKRVTPSIVKSARRGDETAGPPKAVGDQAIAPAAAQLVTRNLIMNGGKDAVRAVKRPAAGKGGVSDDKRAAWYVGYTPDLVTAVALFGEDAEKRKQIPLKNASAQRVADLWSDYTDQALRNVPAAWFDSGSEAGAIPNPTRMAPTGR
>NC_015957.1|WP_014057006.1|4088279_4089548_-|HAMP-domain-containing-histidine-kinase
MTLRWRIVALVAAATCAAAAAVGVLVHHASRDRELSQAREGARTTLDRAALSYARTGGVQGSGAVMDAPGLPQGLRRLVKKGHQGTEFSTGPDGPAMWAARPADGQVLSVRVDMSTAMRNIGALDTNIILAGLMTTAVVLPLGVLTAERMSRRLRLAAATARRIAAGDLDARISAAARPHDEIAEISGAVDSMAAALQERLLDEQRFTADVAHELRTPLMGLVTAAELLPPGEAAGYVRDRVRVLSTLVEDLLEISRLDAGAEEADLSPCPLGPVLDDAIAGTGLSACLRTGGAQDSAPQDPEDGPKVWTDPRRLARIVTNLVINAHRHGREPVEVTVAADGRTVTVRDHGTGYPDDLLEKGPQRFRTGVRERGRGHGLGLTIAAGQAQVLGATLTFGNAPDGGAVATLHLPERPEPGPIHG
>NC_015957.1|WP_014057007.1|4089549_4090323_-|response-regulator-transcription-factor
MTTGFLPPGPAPGTGSPTEAHLLLVEDDKVIRNTVRMALERYGFTVFTAGDGLTGLEIFREKQPDLLLLDVMLPELDGIGLCRRVREFSLAPILMMSARGDALDVVSGLEAGADDYVIKPCESAVLVARIRSLLRRASFTPAARASHAEARNGAAEPDGAAGPDTLAFGDLTIDTLGMEVRRAGEPLALTPTELRMLLEFAGSPGVVLERRTLLNRVWDHAWQGDTRVVDLHVQRLRAKIGAERIETVRGFGYKLRR
>NC_015957.1|WP_014057008.1|4090319_4091102_-|hypothetical-protein
MRSLPHASRTARRRPRPRLPRGLLSAVATACAIVTAAGCAAQSGVRDDGAAPSLSAPVSAVPLWPRYTPSATSSPRQKPDFDRYLPVSRLRLPSGGLTAVSAQDLLLNDPNVPALVQKEISVCPGSGDCPLRGAVHRDLTGDGKDEQVVAVDLPRLDRTLLQVYTASGRTVRPVLIYWGPPGLTGETFGRDLLISATGEDGRVTTRFRWNGRVMAAVTPEGGAGTRAKEPGADPGVVPEPAPGSSLTAVPDPRTETRTTR
>NC_015957.1|WP_043239043.1|4091248_4091824_-|PAS-domain-S-box-protein
MATLAPDLHVVAGDEDFCRHFGASSAELCGRSLFDLLHPSTSSVLREHFSRLHDGRRTRFTERVLGCHSRGQVFSGKLTGTAIQGRSDRLSSIVVMVKPDDERPEEAPAPTSQKLLSPLEARILEGVATGASTVQMAAKLYLSRQGVEYHVGSMLRKMKAPNRAALVSRAYAAGMLTVGTWPARVRPEFVK
>NC_015957.1|WP_050993680.1|4092171_4092636_-|hypothetical-protein
MPTFDTMGHATKETLGTVGQATKGTLDTVGQATKGTLDTVGHATKETFDTVGHATTRATGGAARVALKPVEMARRVLPAKGGLPLYLGLGALGAVEVIEWPVAVGIGVGYAVLRKGGIMAPPAEKGTEGRTADRSKSSRSGSRAKTSKSAKAAA

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Crispr_ID: NC_015957_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015957_15

7441565-7441715

Orphan

Consensus_repeat	Method
TCACCGACCCCCTAGGTCACACCAC	CRISPRCasFinder

2 spacers

WYL,RT

The CRISPR arrays of NC_015957_15

>merge|NC_015957|15|7441565-7441715|CRISPRCasFinder
TCACCGACGCCCTGGGTCACCCCACCCAGATCGCCACCAACGCTGCTGGCCTCCCAGTCGCCATCACCGACCCCCTAGGTCACACCACGCACTTCCGCCGAGGCCCTCACGGCCAGGTCACGGCCGTCACCGACCCCCTAGGTCACACCAC

>NC_015957|15|14|7441565-7441715|CRISPRCasFinder
TCACCGACGCCCTGGGTCACCCCAC	CCAGATCGCCACCAACGCTGCTGGCCTCCCAGTCGCCA
TCACCGACCCCCTAGGTCACACCAC	GCACTTCCGCCGAGGCCCTCACGGCCAGGTCACGGCCG
TCACCGACCCCCTAGGTCACACCAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015957.1\|WP_043240320.1\|7445775_7446864_+\|transposase	unknown	unknown	gnl\|CDD\|372671
NC_015957.1\|WP_167543240.1\|7452118_7452547_+\|transposase	unknown	unknown	gnl\|CDD\|222853
NC_015957.1\|WP_014059429.1\|7431141_7431981_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|375319
NC_015957.1\|WP_014059434.1\|7435710_7436802_+\|transposase	unknown	unknown	gnl\|CDD\|222853
NC_015957.1\|WP_106685978.1\|7435242_7435614_-\|transposase	unknown	unknown	gnl\|CDD\|372671
NC_015957.1\|WP_014059430.1\|7432079_7433060_+\|WYL-domain-containing-protein	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|225253
NC_015957.1\|WP_014059446.1\|7453272_7456038_-\|LuxR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197715
NC_015957.1\|WP_014043695.1\|7449861_7450170_+\|transposase	unknown	unknown	gnl\|CDD\|366690
NC_015957.1\|WP_014059436.1\|7438473_7438824_+\|SseB-family-protein	unknown	unknown	gnl\|CDD\|377787
NC_015957.1\|WP_014059443.1\|7447250_7448081_-\|AfsR/SARP-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|276938
NC_015957.1\|WP_043236793.1\|7438810_7439365_+\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014059450.1\|7497018_7497927_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|369561
NC_015957.1\|WP_078505468.1\|7451085_7452225_-\|RNA-directed-DNA-polymerase	RT	pfam00078_RT_CAS-I:CAS-III	gnl\|CDD\|238828
NC_015957.1\|WP_043236786.1\|7430482_7431073_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_015957.1\|WP_014059427.1\|7429352_7430231_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|378924
NC_015957.1\|WP_078505466.1\|7436834_7437155_-\|Lsr2-family-protein	unknown	unknown	gnl\|CDD\|378714
NC_015957.1\|WP_106685742.1\|7450816_7451089_+\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|222853
NC_015957.1\|WP_014059449.1\|7477923_7496430_-\|type-I-polyketide-synthase	unknown	unknown	gnl\|CDD\|225858
NC_015957.1\|WP_014059431.1\|7433211_7434240_+\|NAD(P)H-binding-protein	unknown	unknown	gnl\|CDD\|225807
NC_015957.1\|WP_043240316.1\|7443922_7444678_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_015957.1\|WP_043240320.1\|7445775_7446864_+\|transposase	gnl\|CDD\|372671	pfam13683, rve_3, Integrase core domain.	2.56597e-12
NC_015957.1\|WP_167543240.1\|7452118_7452547_+\|transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	1.64516e-44
NC_015957.1\|WP_014059429.1\|7431141_7431981_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|375319	pfam17765, MLTR_LBD, MmyB-like transcription regulator ligand binding domain. This domain is found in a family of actinobacterial transcription factors. The structure shows it has a PAS domain like fold and it is bound to Myristic acid.	1.40893e-41
NC_015957.1\|WP_014059434.1\|7435710_7436802_+\|transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	5.44495e-06
NC_015957.1\|WP_014059427.1\|7429352_7430231_-\|alpha/beta-hydrolase	gnl\|CDD\|378924	pfam12697, Abhydrolase_6, Alpha/beta hydrolase family. This family contains alpha/beta hydrolase enzymes of diverse specificity.	2.41679e-11
NC_015957.1\|WP_014059430.1\|7432079_7433060_+\|WYL-domain-containing-protein	gnl\|CDD\|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	3.33111e-43
NC_015957.1\|WP_014059446.1\|7453272_7456038_-\|LuxR-family-transcriptional-regulator	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	2.3088e-15
NC_015957.1\|WP_014043695.1\|7449861_7450170_+\|transposase	gnl\|CDD\|366690	pfam01527, HTH_Tnp_1, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.	3.3962e-10
NC_015957.1\|WP_014059443.1\|7447250_7448081_-\|AfsR/SARP-family-transcriptional-regulator	gnl\|CDD\|276938	cd15831, BTAD, Bacterial Transcriptional Activation (BTA) domain. The Bacterial Transcriptional Activation (BTA) domain is present in the putative transcriptional regulator Mycobacterium EmbR and the related Streptomyces antibiotic regulatory protein (SARP) family of transcription factors, which includes DnrI and AfsR, among others. Members of this family contain an N-terminal DNA-binding domain, followed by the BTA domain, and many have diverse domains at the C-terminus. EmbR contains an C-terminal forkhead-associated (FHA) domain, which mediates binding to threonine-phosphorylated sites in a sequence-specific manner. The BTA domain of EmbR contains three Tetratricopeptide repeats (TPRs) and two C-terminal helices. The TPR motif typically contains 34 amino acids, and 5 or 6 tandem repeats of the motif generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein.	1.34868e-51
NC_015957.1\|WP_014059450.1\|7497018_7497927_-\|alpha/beta-hydrolase	gnl\|CDD\|369561	pfam07859, Abhydrolase_3, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	1.08874e-79
NC_015957.1\|WP_078505468.1\|7451085_7452225_-\|RNA-directed-DNA-polymerase	gnl\|CDD\|238828	cd01651, RT_G2_intron, RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable element with both gag-like and pol-like genes. This subfamily of proteins appears to have captured the RT sequences from transposable elements, which lack long terminal repeats (LTRs).	5.80041e-49
NC_015957.1\|WP_043236786.1\|7430482_7431073_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.0596e-14
NC_015957.1\|WP_106685978.1\|7435242_7435614_-\|transposase	gnl\|CDD\|372671	pfam13683, rve_3, Integrase core domain.	2.593e-07
NC_015957.1\|WP_078505466.1\|7436834_7437155_-\|Lsr2-family-protein	gnl\|CDD\|378714	pfam11774, Lsr2, Lsr2. Lsr2 is a small, basic DNA-bridging protein present in Mycobacterium and related actinomycetes. It is a functional homolog of the H-NS-like proteins. H-NS proteins play a role in nucleoid organisation and also function as a pleiotropic regulator of gene expression.	6.03764e-21
NC_015957.1\|WP_106685742.1\|7450816_7451089_+\|IS3-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	2.46039e-16
NC_015957.1\|WP_014059449.1\|7477923_7496430_-\|type-I-polyketide-synthase	gnl\|CDD\|225858	COG3321, COG3321, Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism].	0
NC_015957.1\|WP_014059431.1\|7433211_7434240_+\|NAD(P)H-binding-protein	gnl\|CDD\|225807	COG3268, COG3268, Uncharacterized conserved protein [Function unknown].	3.36508e-47
NC_015957.1\|WP_014059436.1\|7438473_7438824_+\|SseB-family-protein	gnl\|CDD\|377787	pfam07179, SseB, SseB protein N-terminal domain. This family consists of several SseB proteins which appear to be found exclusively in Enterobacteria. SseB is known to enhance serine-sensitivity in Escherichia coli and is part of the Salmonella pathogenicity island 2 (SPI-2) translocon. This entry contains the presumed N-terminal domain of SseB.	0.00380284

>NC_015957.1|WP_043236793.1|7438810_7439365_+|hypothetical-protein
MAEHDGGASSSGGPKPGDGYRIEIASVRKVLTPLEESVVAARKIKGDWKTLAETIQNSADFDIYDSAEKMLSSWGFGMGRVAEHTGTVVETLRQVIAAYIMADLLRIKDFTPTADNMAKLPFGEAGIKAWQAGSRPKFDPPPEIYQEPWLDDSGTGGTQDVPTNPRKRYDGGWEVDGGSKGTIA
>NC_015957.1|WP_014059436.1|7438473_7438824_+|SseB-family-protein
MSLRDLIRDEMAASRPRSERLAALRSARLYFQRPDEPGFLVSDTAQGPVVPVFTSLERLALFAGPCGWASTTVEDLVELLPEGVCALVDPLSPRAFVLDTEALQSTDGQGERSGRA
>NC_015957.1|WP_078505466.1|7436834_7437155_-|Lsr2-family-protein
MCVEENDDSGDAESYRYLRIGQKPAQGGEEFVFAPENCDKLDAALRPFIEKGRNLGRMKETGRVRRGAADGPSAEEVRAWARENGHEVNDRGRVPKEIRDALDASH
>NC_015957.1|WP_014059434.1|7435710_7436802_+|transposase
MLLRLAYLTATNALAFLRLLPMSDRDKDIEILVLRHQLLVLQRQVGKPTLTDSDRAILAGLLHHLPKDRLRHLLLLVRPDTVLRWHRNLLRRRHATTCVPKRRGRPRTIRSIRALTLRLARENASRGYRRIHGELAALGIRVAASTVWEILREHGVPPAPARQSTTWADFLRSQAKALLACDLFEVRTLTGARLYVFAVIEHTTRRIRILGATAHPTAEWIVQLGRNLLMDLEDAGARARFLIRDRDSKFTTAFDVLMADAGLKVVTTGIRIPRMNSVMERWIQTCRTELLDRTLIWNQSHLLHALREYESFYNEHRPHRALEQAAPCRPLPAPITQQAQLAHLKIDRRDRLGGTLHEYGRAA
>NC_015957.1|WP_106685978.1|7435242_7435614_-|transposase
MDDLSAPAKFPDLFDAVLADAGIEVVLSGVRMPRMNSIMERWVQTCRRELLDRTLIWNHRHLLHALREFEQFYNAHRPHQGIANARPLHPLPAPIDDPDTLARLDIRRRDRLGGLLHEYQHAA
>NC_015957.1|WP_014059431.1|7433211_7434240_+|NAD(P)H-binding-protein
MAAIPRLLVYGATGYTGKLVAEHAKQSGLDVVVAGRNRERVTALGKELGVESRAFALDDPQILHAALDDITVVLNVAGPFRHTARPLMDASINAGVHYVDTTAEYDVFAAAHSRHTEAQAAGVMLMPGAGWDVVPSDSIATHTATRVTDPVSLRLALKLLSATPEEAQGLNLFSRGSIISATEGIGDLGVLVRTDGDIVALPEPKVASFDFGDNGPEEAVSASMGDLITSHFATGIPSIEVYVQAGQPLPIDLDLSALPDGPTAQEREVGRSKVVAEVTGRNGSVARSIIDTPTGYRYTQLSSVEIARRVLAGSFTPGFQSPSSAYGPEIALAIADTQIKDL
>NC_015957.1|WP_014059430.1|7432079_7433060_+|WYL-domain-containing-protein
MITTSARLLRLVSLLSSRPTWSNAELARHLDVTERTVRRDIDRLRELGYGVQSIPGPGGGYRFGAGNRMPPLNLDDDEVFAVAMALREAAQGAALGADPAALSALLKLRQILPARMAKRLESLDATVEHTPRCESPRASADVLFLLASVCRASERATLTYRDAHGTTTVRCVDPYRLVHTGVHWYFVARDVEHATWRTFRADRVVDVESTGDMVDLSDAPDAARLVSDTITRTGYPFFARVRLPLSFDDSRRLVAPIVATHEPDGPDHTIITIGGAEPDQLAGYLLSLRTPLEVLSPDSVREALLARLDALYRGNDAPRPGSGETQ
>NC_015957.1|WP_014059429.1|7431141_7431981_+|helix-turn-helix-domain-containing-protein
MQQAQNELGAFLRANRARTEPADVGLPPGGGSRRVKGLRREEVAVLAGVSVDYYARLEQGRERNPSPQVIDAVGRAMRLMPDARTHLFRLAGLHPALTSAADRDLVHPSLLHLLDAFPAAAAYVLSPAFDILAKNAVAAVLLAPFDGTSNMVRVLFHHPRAREVFVEWPTVARATVQALRLHGGRFPDDPGIIDLVSELSATSAKFRELWQDNEVENMARAFKVFVLPETGRIELTYQTFDVHDAPGQQLLVGVPEPGSASAAAIESLRTPAERGASTA
>NC_015957.1|WP_043236786.1|7430482_7431073_+|TetR/AcrR-family-transcriptional-regulator
MNASHSSAAASPARTRLLETASNVFYADGIRHVGVDRIIAEAQVTRATFYRHFPSKEDLVLAHVEQRDQQIRSAVTEAFRTTTDPEALLIMLMAGIGEEICGPGFRGCPFINAAAEYPDPEHPVRQAVQAHRSWFRQTVQNLVAAAGCPDSEHTTAVLVLLRDGAMAGGNLDDPASVRDHLMRTARAVLAEGRSVR
>NC_015957.1|WP_014059427.1|7429352_7430231_-|alpha/beta-hydrolase
MSRRHTQPARRSRRALLALAAATALAAAAVPTLAHGASGAGPAAVSAAGTSSHAATKPTVVLVHGAWADSSSWSPVIDRLQAQGYPVQALANPLRGLASDAAYVKSRIESIDGPVVLVGHSYGGAVISEAAAQEHNVKALVYAAAFAPAKGETVGALAAKDPGSHATPDALNPIPFDAGNGASGVDVYIKPDKYRDVFAGSLSARKANSLAAVQRPINAAALEETVTDAAWQDIPSWYLMTRQDHALPPATQRFMAERAHAHIAEVNAPHAVMLTRPDTVTSLILHAATATR
>NC_015957.1|WP_043240316.1|7443922_7444678_+|hypothetical-protein
MRFSVGDTVNAETTRNPLTFTPRFDFTDLQVIVAEYTDPKEREQHLAHTFGSMQWLWSEHDEFRFDQSSRELSHATFYVPRDSAPSPLCHRAPPEPQRLPGGLRTDTTQNFALPQATIFCCDPEAAELRCYRDLSVLDGEPDALIGIAPDVGLLVKGGAVAGWSLTDPARYLTDGFADPEATPPSHTTRLRLAECLNLVTAPLIDEVMDQDADTWRRLRAIERDLRDQRNDRNRATIMHRVISRLIEDNES
>NC_015957.1|WP_043240320.1|7445775_7446864_+|transposase
MIVSLVYQVTRKLLSVPAVLLRRQTARDAELLVLRHENAVLRRQLASPVRYQWTDRLWFAALSSLIPRRRWAQAFPVTPGTLLRWHRRLVARRWDYSECRTRPGRPATAEAVKELVLRLARENPRWGCRRIQGELARLGHKIGASTVWKILTAAGVDPAPRRSGPTWREFLTSQSEAIIACDFLHIDLASLRRVYALVFLEHGTRRLHIAGVTAHPTAQWTAQQARNLALEVGVRLESLRFVIRDRDSKYTESFDAVFEAEGIETLKTAPRPPRMNAHCERVIGTLRRELLDHVLIWNDTHARHVLDVYARHYNGHRPHQARGQRPPLTDSRTAPLTDSSTPRRLLQTRVLGGLINEYRHAA
>NC_015957.1|WP_014059443.1|7447250_7448081_-|AfsR/SARP-family-transcriptional-regulator
MDIGILGPLVVGANDREATPSAPKPRQLLALLAAHAGRVVPVDLMVDELWESTPPPSALTTVQTYIVLLRRLLAKSLQVSSAEVAREVLTYTGWGYQLAAGKGTHDASLFARYADLGRRALAAGDNSRASGALREALAFWRGPALADIRTGPHLLAHRVSLEEQRMGAVEQRIEADLRLGRHHELIGELSGLTVQHPLHENMHSLLMIALYRSGRPGQALETFQKLHQNLRNELGMEPSPNTRTVQQRILRRDSTMEADQQSKLFPQEIIPSRPTG
>NC_015957.1|WP_014043695.1|7449861_7450170_+|transposase
MPAPRKYPLELRDRAVRMYRAAEPKPVIRRMAEELGVHHEALRNWIRQAEADAGERGDILTTAEREELAALRKENAQLKRANEVLRTASAFFAAQLDPTRPR
>NC_015957.1|WP_106685742.1|7450816_7451089_+|IS3-family-transposase
MGSVGDSFDNALAENLWMVIKTECIRGRVFPTRAEANLTLFEYIDGFYNPRRIQKRLGYLSPIEYEEKHYASQATAEQVNLKPRQPSLTS
>NC_015957.1|WP_078505468.1|7451085_7452225_-|RNA-directed-DNA-polymerase
MRPESFLILRRHSAISSASRGSSVRMWSATCHPTIIREYICFGSLDHDVMLSILSEKIHDGRFLRLIGHMLKAGYLEDWRWDATLSGAPQGGVASPILSNIYLDRLDQFVEQSLLPEYNRGRRRQPNRAYRRLEHWIQGARRRGDWKSVRELEPRRRALPSQDPNDPDYRRLRYVRYADDWLLGFAGPRHEAEEIKSKVRTFLQEELKLELSEAKTLITHATRQAARFLGYEIKSQYSNDKITRNRRAVNGSIGLFVPRQAIRQRCALYMKKGKPALRGSVMRDDDFTIVAKYQSEFQGVVQYYLLAQDVFRLGRLRWVMETSMLKTLAGKHRSTVTKTARKYKRLIETPDGPRTCFQVTVERDRGRKLRFPRCTGVAD
>NC_015957.1|WP_167543240.1|7452118_7452547_+|transposase
MIVGWQVADHMRTELPLDALEMALWRRRIKKDSGLIHHSDRGSQYVSIRYTGRLADIGASASVGSVADSYDNAMAEALNGTFKAELIEMQGPWKDPAQVERAIFQWVTWYNEERLHSALDYVPPAECERDFWQSQEQTPQSA
>NC_015957.1|WP_014059446.1|7453272_7456038_-|LuxR-family-transcriptional-regulator
MLERDERLGRLTELIDRGDEETGTTGIISGAVGFGKTALLEVLVARAADRGYTVLSAAGSQVQRAFPYGVMEQLFLDAEVAGADMDLHASLQRVREAQEERSPLASEAGAAQAMQAYHGLLVELSAHRPVVLCVDDIQHADPESLACLLYLIGRCRRIPVTILLTLGPSGIAPYDGVLPELVCRPGVVHVKLGAFDPGDMARLIADRFGQAAAEQYTPGFYAMSGGNPLLVQALLSDHTARRAHPEEGYSPVAADLFREASVACTRRSGPNGLQVARGISIASGAGSPALLAQLVGLEKSEVESAMKILTESRLIEGLRFRHRAIRAAVLDNMSAADRRRLHHRAAGLLHNDGAPAIVVAQHLVAGGTAEDDWAPQLLMDAAGQALREDRVSLAGQCLQLADSCCHDRSLSHVIKANLARIKWRDQPEAAVRMMLSLVSPARTGDLPGAIRLEVAHCLLMQGRVSVAVEVVRPLFADQEDYLAPELDVTRLWLAVTYPAAYKQLVGGASSAPHLQAPSYQIGRPRLSAIHTLWAVLTRGADDMLAAEAERVLQHLPAEDETIISLNSAIAALIYADQLESAAAWCGQLQTAATERRAPTWHALFTSTRAMIALRRGSLRVAAESAETALLSMSVEAWGVEVGMPFATAIEARTAMGDHAAGAELVNSPVPNGLLETRFGLHYLYARGRHYLATGYYDAAIADFTLCGEKAQAWGLDSPTLAPWRIGAAEVWLHRGRRERASKLADEHLALVKRDQPRALGIALRVQAAARPPSQRIELLGTAMDMLQSAGDRYELALTLVELCRTHHRQGEAAQARLLVRQAWRMADECGAEGLSSSLVLKPVSVVQVEEPQSRPPADDVVTNMLSEAEMRVCSLAARGHTNREISDKLFVTVSTVEQHLTRAYRKLNIRHRRELPASLAS
>NC_015957.1|WP_014059449.1|7477923_7496430_-|type-I-polyketide-synthase
MNHEISGSDVAVIGMACRLPQAPGPADFWQLLRTGTNAIGDVPADRWPDRAGNDGHDDALRALVRRGGFIEEPDAFDAAFFGVSPRESAEMDPQQRLALELSWEALEDAGVVPESLRGLPVGVYVGAMASDHANLTSLRSPEAINHHTMAGTHRAVIANRISYFAGLRGPSMTVDTGQSSSLVAVHMACESLRTGESRLALAGGVNLNLTEQSALLEARLGALSPDGQCFTFDERANGYVRGEGGGFVVLKPLADALADGDDVYCVIRGSAVNNDGAGDSLLVPTVAGQREVLTRAYTRAGVAPGDVQYVELHGTGTKVGDPVEAEALGHSIGTGQDRDRPLLVGSVKTNVGHLEGAAGITGLLKVALMLKHREIPASLNFNRLNPGIRAAEWNLQVVTEPVPWPDPDGTLLAGVSSFGMGGTNCHVVLSSPVRNAVEPTPGAAPGELALVLSAKSATALRGQAERLLEQVTAEPSLNTADVAWSLIGSRSAFEHRAVVLGGGRDELTAGLAGLVSGEPAAGLVQGQAREDRRVAFVFPGQGAQWTGMASELMESSPVFRAAMEECAEALRPFVDWPLTDVLDDQAALERVDVVQPALWAVMVSLARLWRWMGVEPAAVVGHSQGEIAAACVAGGLPLAEGARVVALRSRAIAEALTGRGGMAVVSLPAQEAAELIAPWDGRLSIATVNGPGSVAVSGETEAIEELAAQCADSGIRVRTVSVDYASHSAAVEEIESRLLADLEPLRPRSGTVPMYSSVTGAPVDTAGLDARYWYRNLRQTVQFETATRALAADGISVLVEVSPHPVLTVPVQDTLDSLDGPDGKEAVVTGSLRRDEGGLDRFLTSVAQVHVQGVPVSWTSLFEGRQPRRVKLPTYAFQRDRHSVLGLGQGPARLLEAEPVAALASADEDDAFLRKLAPLSPKERDSHLLSVVRDHAAALLGHRGGDDVDPTVPFRAAGFDSMTAVDLRNRLQTVTGLAIPSSMVFDYPTPARLAAFLAGRLGGTESADDTVVPSAAPLDDDPMVIVGMSCRFPGGVADPEQLWDLVIGERDAITGFPTDRDWDLEHLYGPDTAGRLAGGFVDGAMDFDAGFFAMSPREALAMDPQQRLLLEGSWEALEHAGIDPVSLAGSATGVFVGSYQSGYSEVVSAALADADAQLLTGGAQSVLSGRVAYSLGLVGPAVTVDTACSSSLVALHLAGQALRGGECSLALVAGVTVNALPHTFVGFSQQGGLSADGRCKAFAEAADGTGFSEGAGVVVVERLSDARRNGHRVLAVVRSSAVNQDGASNGLTAPNGPSQQRVIRQALAAAGLDSGDVDAVEAHGTGTSLGDPIEAQAVLATYGQDRPDDRPLWLGSVKSNLGHSQAAAGVAGVIKMVLAMRRGVLPRTLHVDEPSTHVDWSQGRVRLLTQEQPWPETGRPRRAGVSSFGISGTNAHVILEAAPGLGTEPEAETAVEDGAETVWVVSARSEQALRGQAERLVSAVESLEPAGVGAALLSRSLFDHRAVVVGADRDELRAGLRAVAAGEPVANAVEGVARPGGRVAVLFAGQGAQRLGMGRRLYGESGVFAAAFDEVVAELDRHLESPLRDVIWGEDAEVLNATGWAQPALFAVEVALFRLLQSFGVVPDYLLGHSIGEVAAAHVAGVFELADACRLVVARARLMQALPAGGAMVAIAAPEEEVLPYLSEDVSIAAVNAPGSVVISGARAAVMEVGEHFTAQGVKTTRLRVSHAFHSVLMEPMLDDFMAEIADVSFSEPRIPVVSNLTGEPADMSSPGYWARQVRSAVRFADGLAWLAGQGVDTFVDAGPDGVVAGLAQANAAGAVAVALMRKDRDGLRTALVAAGDLFVRGVPVAWDTLFAGSTPRWVDLPTYAFQRRRYWPQASIAGGDVTAAGLASAGHPLLGAVVSVPNSGTVVLTSRLSLRTQPWLADHAVHGTVLFPGTGFVELAIRGADAVGAGGLRELIVEVPLVIPESDSVQVQVVVDDGTAVIYSRPADDDPWTRHATAVLGDALAAEPDGWQWPPADASWVDLSGFYELTADSGLVYGPAFQGLRQVWQADGAAFAEVAVAENEADRARKFGVHPALLDAAVQASAYAELDPAPAGRVPIGFADVTLHAEGATATRVRVARTGPDSVSVQLADGNGDAVLSIGSVTLGAPPTSGLSAASQSGTALALDWPELPAPEDHADVRLAFVQAPASDASWLPETAYTNLEDVLAEENPPQYVTLAVSVGEPDDMVRAVHATTRWALEQLQSWLAEERFADTTLVVLTRGAIAAHHDEPVPDLGAAAVWGLLRTAQMEHPGRILLVDAEPRHDLDVRQLAMALRTGEPQLALRGQEIRAARLARVTPRDEPEPRVDPEGTVLVTGGTGGLGREMARHLVAAHGVRSLLLLSRRGTAAGGAQELIDELSAQGAEVTVAACDVGDRAALAAVLAGTTLTGVVHTAGVVDDGLVSSLTAERLDRVLVPKVDAAWALHELTAGMDLSFFAVFSSLSGILGNPGQANYAAGNVFLDALMQARRHAGLPGVSMAWGAWTQDVGLTAALSEADMRRLARSGMRPLSVPQGLALFDRALVSDRALLGLASLDLAALRARDDLPVFRSLVGGRARRRAGDQRQPAGGLAERMAGLPEPEREDYLLTLIRDHAAAVLGHASGQHLNVTTAFREMGFDSLMGIELRNRIKRGTGLPVADSMVYDYPTPLRLAQYLASLVGGVELRVGGAAQARVLADDDRLAIVGMACRFPGGVTNPDELWKLIAEGGDAIAAFPDDRNWDIEQLYDAEGARSGSSVTRSGGFIDADGFDSTFFGISPREALAMDPQQRLLLESSWEALEDAGIDPQSLAGSSTAVMFGISQSGYGELVSPLEEAQGHLLTGGAFSVASGRVAYTLGLEGPAVTVDTACSSSLVALHLAGQALRAGECSLALAGGVTVMATPGTFVEFSRQGGLSSDGRCKAFADTADGTGWSEGLGVVVVERLSDAERNGHQILAVVRASAVNQDGASNGLTAPNGPSQQRVIRQALAAASLAPSDVDVVEAHGTGTTLGDPIEAQAVLATYGQDRPDDRPLWLGSLKSNIGHTQAAAGVAGVIKMVLAMRHGVLPQTLHVDEPSSRVNWSQGRVRLLTESVAWPETGRPRRAGVSAFGMSGTNAHVILEAPAEIEAEAEPESGALPPAVAWVVSARTDQALRGQAERLLSAVVESAEPVDVGAALLSRSLFDHRAVVVGTDRDELASGLQALAGGEPAANVANGVARAGQGRRVVFVFPGQGAQWVGMAGGLVDSSEVFRESMAECAEALAPFVDWSLLDVLEDEAALARVDVVQPALWAVMVSLARVWRSWGVEPAAVVGHSQGEIAAAVVAGGLSLSDGARVVALRSQAIAGVLAGQGGMVAVSLPVDEVRELLPEGVSVAVVNGPGAVVVAGPVEALDGVIARCEEREVRARRVPVDYASHSASVELIEDRLAADLAGLAPVSSSVLMYSSVSGTPIDTAGLDAGYWYRNLRQTVEFEQATRALAADGFTAFVEVSPHPVLTMALQDTVGEDAAVTGTLRRNEGGLERFLLSAAELFVRGVPVAWDGLFAGRTSGRVELPTYAFQRRRFWPQPSLVAGDVAAAGLVSVEHPLLGAVVSVPGSGTVVLTSRLSLRAQPWLVDHAVHGTVVFPGTGFVELAIRGADAAGAGRLRELIVEAPLVIPERDSVQVQVVVDGDDHTVGIYARTGEDEPWTRHATGVVDDETAAVDAGELAGAWPPPGSTPVDLDDFYQRSADNGFGYGPVFQGLTRAWQHNGQIFAEAALPDDQGAAAIAFGIHPALLDSALHPNTFADLDATELGRLPFTFNDVTLHATGAKAVRIRMARTGPDSVTAVLADETGAPVLSIGSLIMRPVPEQVFGAARTPETMLALAWNEVPETDGVASASDDDVLLEVPAAADTTPESVHTAVEWVLTQLQGFTGNRLVVLTHGAVAAGPGETVADLAAAAVWGLVRSAQSEDPGRIVLVDADADTQATPELLARAAGTGEPQLAVRAGTLLAPHLTRTNATGEPVTLDGTVLITGGTGGLGSAVARHLVAAHGVRSLLLLSRRGAAAPGADALVEELTAQGAEVKVVACDAADRSALADVLAGVPLTGVIHTAGILDDGVISTLTPEQVHRVLTPKVDAAWHLHDLTRDQDLSMFVVFSSLAGLIGSPGQGNYAAGNVYLDSLVQQRRSAGLAGISMAWGPWDQSLGLTGALSGTDMHRLGRLGMLPISEDQGMILFDRALAAGQPLLGLTELKTSALRATAEIPALFRSLAGGPARRTRARAGVAERTGGLAGQLADLTPEQRQSHLLALVRDQVASVLGYQSGTDIDESKPFREVGFDSLTAVELRNRLQTVTELSLPSTLVFDYPNAVRLADFLGERLGGVAAVPVDALPVLRSVEEDPLVIVGMSCRFPGGVADPEQLWDLVIGERDAITGFPTDRGWDLEHLYGPDTAGRLAGGFVDGAMDFDAGFFAMSPREALAMDPQQRLLLEGSWEALEHAGIDPVSLAGSATGVFVGSYQSGYSEVVSAALADADAQLLTGGAQSVLSGRVAYSLGLVGPAVTVDTACSSSLVALHLAGQALRGGECSLALVAGVTVNALPHTFVGFSQQGGLSADGRCKAFAEAADGTGFSEGAGVVVVERLSDARRNGHRVLAVVRSSAVNQDGASNGLTAPNGPSQQRVIRQALAAAGLSPTDVDAVEAHGTGTTLGDPIEAQAVLATYGQDRPEDRPLWLGSVKSNIGHSQAAAGVAGVIKMVLAMRRGVLPRTLHVDEPSTHVDWSQGRVRLLTQEQPWPETGRPRRAGVSSFGISGTNAHVILEAVPAVEPEVEAGGDGGSVWVVSGRTQQALRGQAERLVSAVESLEPAGVGAALLSRSLFDHRAVVVGADRDELRAGLRAVAAGEPVANAVEGVARPGGRVAVLFAGQGAQRLGMGRRLYGESGVFAAAFDEVVAELDRHLESPLRDVIWGEDAEVLNATGWAQPALFAVEVALFRLLQSFGVVPDYLLGHSIGEVAAAHVAGVFELVDACRLVVARARLMQALPAGGAMVAIAAPEEEVLPYLSEDVSIAAVNAPGSVVISGARAAVMEVGEHFTAQGVKTTRLRVSHAFHSVLMEPMLAEFTSAIADVTFSLPQIPVVSNLTGEPADMSSPGYWARQVRSAVRFADGLAWLAGQGVDTFVDAGPDGVVAGLARTDAAGAVAVALMRKDRDGLRTALVAAGDLFVRGVPVVWDELFGGRKPGRVDLPTYAFQRRRYWPQASIAGGDVTAAGLASAGHPLLGAVVSVPNSGTVVLTSRLSLRAQPWLADHAVHGTVLFPGTGFVELAIRGADAVGAGGLRELIVEVPLVIPESDSVQVQVVVDDGTAVIYSRPADDDPWTRHATAVIDPEGSPAGNAVAWQWPPMDAAQADVADFYQSLADDGFAYGPVFQGLRQVWVGPEEVFAEVTVADEEADRARKFGVHPALLDAALQASTFVGLEPAPAGRMPFSFTDVTLHAGGATATRVRVVRTGPDSVSVELADGSGEPVLTIGTLVLQPVTATGPVGDAQAGSVLTVDWSSTITLDDDPAPGADLQVVGAPNDIVLDDIDPAAVVVLEASGSGDVPQSAHHLTGWVLTQVQRWLADERCADGRLVVVTRGAVATVPGERVGGLAASAVWGLVRSAQAENPGRITLLDIDDQTAQLDAGFVARAAVSAEPQLVVRDGVVGAARLVRVAAAPEQEPVGFGEGRVLVTGGTGGLGREVARHLVRAHGVRDLLLVSRGGGGADLVAELEELGARAVVAACDVSDREALATLLEGVDLSAVVHTAGVVEDSVVTSLDGARLDRVLAPKVDAGWYLHELTADRDLSAFVVFSSLAGMLGSPGQGNYAAGNVFLDTLMEQRRAQGLPGVSMAWGPWAQGAGLTSGLSETDMRRISQSGTPPFTVEQGLRMFDEALAVPRAAVAVTRLDLGALRGRADLPPLWRALTGKRARPAAADRRQDAGTLADRLAGLAIPERTEQLLVLVREHVAAVLGYASREHIDTNQAFRELGFDSLSALELRNRLQVATGLTIPATLVFDYPNSQRLATHLAGQFGTAESTDTGAASLLSQMDTLSGALKRAELVDGEREAIANRLRSMLDAWRASDEEDPDEEWETPDEVFRFIDDELGISEREV
>NC_015957.1|WP_014059450.1|7497018_7497927_-|alpha/beta-hydrolase
MPLDPSVKAVLDILDAAGDKQLYELPIPVARAAYDQLAGFGGEPAAVGRTEHTSADGVPVRLYWPESPGPHPVLLFVHGGGWMLGSLDGYDGVARDLSVHADCLVVSVGYRIAPGNCFPAAVEDVVTAAKWVMRTGESFGGDVSRLAVAGDSAGGNLSAVLVNELPGRFRAQALLYPATDQTRQHPSVRENGQGYLLTEGTLRWFSENYLGDQDPRHPWASPLYAADEVLAAAPPTLVVTGEFDPLRDEGEAYAARLRALGVRVEHRRYDGMIHAFFSMRGMVPAAGEALRQVTDFLQDAWA

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Crispr_ID: NC_015957_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015957_14

7441184-7441338

Orphan

Consensus_repeat	Method
TCACCGACCCCCTAGGTCACACCAC	CRISPRCasFinder

2 spacers

WYL,RT

The CRISPR arrays of NC_015957_14

>merge|NC_015957|14|7441184-7441338|CRISPRCasFinder
ACACCGACTCGCAGGGCAACACCACCACCTACGTCTGCAACGATGCCTACAAGGTCATCGCTGAGACCGACCCGCTGGGCAACACCACCCGCACCGAATGGGACGAAACCAACCGCCGTCCCATCGCCATCACAGACCCTCTGGGTCACACCATC

>NC_015957|14|13|7441184-7441338|CRISPRCasFinder
ACACCGACTCGCAGGGCAACACCAC	CACCTACGTCTGCAACGATGCCTACAAGGTCATCGCTG
AGACCGACCCGCTGGGCAACACCAC	CCGCACCGAATGGGACGAAACCAACCGCCGTCCCATCGCCA
TCACAGACCCTCTGGGTCACACCATC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015957.1\|WP_043240320.1\|7445775_7446864_+\|transposase	unknown	unknown	gnl\|CDD\|372671
NC_015957.1\|WP_167543240.1\|7452118_7452547_+\|transposase	unknown	unknown	gnl\|CDD\|222853
NC_015957.1\|WP_014059429.1\|7431141_7431981_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|375319
NC_015957.1\|WP_014059434.1\|7435710_7436802_+\|transposase	unknown	unknown	gnl\|CDD\|222853
NC_015957.1\|WP_106685978.1\|7435242_7435614_-\|transposase	unknown	unknown	gnl\|CDD\|372671
NC_015957.1\|WP_014059430.1\|7432079_7433060_+\|WYL-domain-containing-protein	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|225253
NC_015957.1\|WP_014059446.1\|7453272_7456038_-\|LuxR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197715
NC_015957.1\|WP_014043695.1\|7449861_7450170_+\|transposase	unknown	unknown	gnl\|CDD\|366690
NC_015957.1\|WP_014059436.1\|7438473_7438824_+\|SseB-family-protein	unknown	unknown	gnl\|CDD\|377787
NC_015957.1\|WP_014059443.1\|7447250_7448081_-\|AfsR/SARP-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|276938
NC_015957.1\|WP_043236793.1\|7438810_7439365_+\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014059450.1\|7497018_7497927_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|369561
NC_015957.1\|WP_078505468.1\|7451085_7452225_-\|RNA-directed-DNA-polymerase	RT	pfam00078_RT_CAS-I:CAS-III	gnl\|CDD\|238828
NC_015957.1\|WP_043236786.1\|7430482_7431073_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_015957.1\|WP_014059427.1\|7429352_7430231_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|378924
NC_015957.1\|WP_078505466.1\|7436834_7437155_-\|Lsr2-family-protein	unknown	unknown	gnl\|CDD\|378714
NC_015957.1\|WP_106685742.1\|7450816_7451089_+\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|222853
NC_015957.1\|WP_014059449.1\|7477923_7496430_-\|type-I-polyketide-synthase	unknown	unknown	gnl\|CDD\|225858
NC_015957.1\|WP_014059431.1\|7433211_7434240_+\|NAD(P)H-binding-protein	unknown	unknown	gnl\|CDD\|225807
NC_015957.1\|WP_043240316.1\|7443922_7444678_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_015957.1\|WP_043240320.1\|7445775_7446864_+\|transposase	gnl\|CDD\|372671	pfam13683, rve_3, Integrase core domain.	2.56597e-12
NC_015957.1\|WP_167543240.1\|7452118_7452547_+\|transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	1.64516e-44
NC_015957.1\|WP_014059429.1\|7431141_7431981_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|375319	pfam17765, MLTR_LBD, MmyB-like transcription regulator ligand binding domain. This domain is found in a family of actinobacterial transcription factors. The structure shows it has a PAS domain like fold and it is bound to Myristic acid.	1.40893e-41
NC_015957.1\|WP_014059434.1\|7435710_7436802_+\|transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	5.44495e-06
NC_015957.1\|WP_014059427.1\|7429352_7430231_-\|alpha/beta-hydrolase	gnl\|CDD\|378924	pfam12697, Abhydrolase_6, Alpha/beta hydrolase family. This family contains alpha/beta hydrolase enzymes of diverse specificity.	2.41679e-11
NC_015957.1\|WP_014059430.1\|7432079_7433060_+\|WYL-domain-containing-protein	gnl\|CDD\|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	3.33111e-43
NC_015957.1\|WP_014059446.1\|7453272_7456038_-\|LuxR-family-transcriptional-regulator	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	2.3088e-15
NC_015957.1\|WP_014043695.1\|7449861_7450170_+\|transposase	gnl\|CDD\|366690	pfam01527, HTH_Tnp_1, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.	3.3962e-10
NC_015957.1\|WP_014059443.1\|7447250_7448081_-\|AfsR/SARP-family-transcriptional-regulator	gnl\|CDD\|276938	cd15831, BTAD, Bacterial Transcriptional Activation (BTA) domain. The Bacterial Transcriptional Activation (BTA) domain is present in the putative transcriptional regulator Mycobacterium EmbR and the related Streptomyces antibiotic regulatory protein (SARP) family of transcription factors, which includes DnrI and AfsR, among others. Members of this family contain an N-terminal DNA-binding domain, followed by the BTA domain, and many have diverse domains at the C-terminus. EmbR contains an C-terminal forkhead-associated (FHA) domain, which mediates binding to threonine-phosphorylated sites in a sequence-specific manner. The BTA domain of EmbR contains three Tetratricopeptide repeats (TPRs) and two C-terminal helices. The TPR motif typically contains 34 amino acids, and 5 or 6 tandem repeats of the motif generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein.	1.34868e-51
NC_015957.1\|WP_014059450.1\|7497018_7497927_-\|alpha/beta-hydrolase	gnl\|CDD\|369561	pfam07859, Abhydrolase_3, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	1.08874e-79
NC_015957.1\|WP_078505468.1\|7451085_7452225_-\|RNA-directed-DNA-polymerase	gnl\|CDD\|238828	cd01651, RT_G2_intron, RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable element with both gag-like and pol-like genes. This subfamily of proteins appears to have captured the RT sequences from transposable elements, which lack long terminal repeats (LTRs).	5.80041e-49
NC_015957.1\|WP_043236786.1\|7430482_7431073_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.0596e-14
NC_015957.1\|WP_106685978.1\|7435242_7435614_-\|transposase	gnl\|CDD\|372671	pfam13683, rve_3, Integrase core domain.	2.593e-07
NC_015957.1\|WP_078505466.1\|7436834_7437155_-\|Lsr2-family-protein	gnl\|CDD\|378714	pfam11774, Lsr2, Lsr2. Lsr2 is a small, basic DNA-bridging protein present in Mycobacterium and related actinomycetes. It is a functional homolog of the H-NS-like proteins. H-NS proteins play a role in nucleoid organisation and also function as a pleiotropic regulator of gene expression.	6.03764e-21
NC_015957.1\|WP_106685742.1\|7450816_7451089_+\|IS3-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	2.46039e-16
NC_015957.1\|WP_014059449.1\|7477923_7496430_-\|type-I-polyketide-synthase	gnl\|CDD\|225858	COG3321, COG3321, Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism].	0
NC_015957.1\|WP_014059431.1\|7433211_7434240_+\|NAD(P)H-binding-protein	gnl\|CDD\|225807	COG3268, COG3268, Uncharacterized conserved protein [Function unknown].	3.36508e-47
NC_015957.1\|WP_014059436.1\|7438473_7438824_+\|SseB-family-protein	gnl\|CDD\|377787	pfam07179, SseB, SseB protein N-terminal domain. This family consists of several SseB proteins which appear to be found exclusively in Enterobacteria. SseB is known to enhance serine-sensitivity in Escherichia coli and is part of the Salmonella pathogenicity island 2 (SPI-2) translocon. This entry contains the presumed N-terminal domain of SseB.	0.00380284

>NC_015957.1|WP_043236793.1|7438810_7439365_+|hypothetical-protein
MAEHDGGASSSGGPKPGDGYRIEIASVRKVLTPLEESVVAARKIKGDWKTLAETIQNSADFDIYDSAEKMLSSWGFGMGRVAEHTGTVVETLRQVIAAYIMADLLRIKDFTPTADNMAKLPFGEAGIKAWQAGSRPKFDPPPEIYQEPWLDDSGTGGTQDVPTNPRKRYDGGWEVDGGSKGTIA
>NC_015957.1|WP_014059436.1|7438473_7438824_+|SseB-family-protein
MSLRDLIRDEMAASRPRSERLAALRSARLYFQRPDEPGFLVSDTAQGPVVPVFTSLERLALFAGPCGWASTTVEDLVELLPEGVCALVDPLSPRAFVLDTEALQSTDGQGERSGRA
>NC_015957.1|WP_078505466.1|7436834_7437155_-|Lsr2-family-protein
MCVEENDDSGDAESYRYLRIGQKPAQGGEEFVFAPENCDKLDAALRPFIEKGRNLGRMKETGRVRRGAADGPSAEEVRAWARENGHEVNDRGRVPKEIRDALDASH
>NC_015957.1|WP_014059434.1|7435710_7436802_+|transposase
MLLRLAYLTATNALAFLRLLPMSDRDKDIEILVLRHQLLVLQRQVGKPTLTDSDRAILAGLLHHLPKDRLRHLLLLVRPDTVLRWHRNLLRRRHATTCVPKRRGRPRTIRSIRALTLRLARENASRGYRRIHGELAALGIRVAASTVWEILREHGVPPAPARQSTTWADFLRSQAKALLACDLFEVRTLTGARLYVFAVIEHTTRRIRILGATAHPTAEWIVQLGRNLLMDLEDAGARARFLIRDRDSKFTTAFDVLMADAGLKVVTTGIRIPRMNSVMERWIQTCRTELLDRTLIWNQSHLLHALREYESFYNEHRPHRALEQAAPCRPLPAPITQQAQLAHLKIDRRDRLGGTLHEYGRAA
>NC_015957.1|WP_106685978.1|7435242_7435614_-|transposase
MDDLSAPAKFPDLFDAVLADAGIEVVLSGVRMPRMNSIMERWVQTCRRELLDRTLIWNHRHLLHALREFEQFYNAHRPHQGIANARPLHPLPAPIDDPDTLARLDIRRRDRLGGLLHEYQHAA
>NC_015957.1|WP_014059431.1|7433211_7434240_+|NAD(P)H-binding-protein
MAAIPRLLVYGATGYTGKLVAEHAKQSGLDVVVAGRNRERVTALGKELGVESRAFALDDPQILHAALDDITVVLNVAGPFRHTARPLMDASINAGVHYVDTTAEYDVFAAAHSRHTEAQAAGVMLMPGAGWDVVPSDSIATHTATRVTDPVSLRLALKLLSATPEEAQGLNLFSRGSIISATEGIGDLGVLVRTDGDIVALPEPKVASFDFGDNGPEEAVSASMGDLITSHFATGIPSIEVYVQAGQPLPIDLDLSALPDGPTAQEREVGRSKVVAEVTGRNGSVARSIIDTPTGYRYTQLSSVEIARRVLAGSFTPGFQSPSSAYGPEIALAIADTQIKDL
>NC_015957.1|WP_014059430.1|7432079_7433060_+|WYL-domain-containing-protein
MITTSARLLRLVSLLSSRPTWSNAELARHLDVTERTVRRDIDRLRELGYGVQSIPGPGGGYRFGAGNRMPPLNLDDDEVFAVAMALREAAQGAALGADPAALSALLKLRQILPARMAKRLESLDATVEHTPRCESPRASADVLFLLASVCRASERATLTYRDAHGTTTVRCVDPYRLVHTGVHWYFVARDVEHATWRTFRADRVVDVESTGDMVDLSDAPDAARLVSDTITRTGYPFFARVRLPLSFDDSRRLVAPIVATHEPDGPDHTIITIGGAEPDQLAGYLLSLRTPLEVLSPDSVREALLARLDALYRGNDAPRPGSGETQ
>NC_015957.1|WP_014059429.1|7431141_7431981_+|helix-turn-helix-domain-containing-protein
MQQAQNELGAFLRANRARTEPADVGLPPGGGSRRVKGLRREEVAVLAGVSVDYYARLEQGRERNPSPQVIDAVGRAMRLMPDARTHLFRLAGLHPALTSAADRDLVHPSLLHLLDAFPAAAAYVLSPAFDILAKNAVAAVLLAPFDGTSNMVRVLFHHPRAREVFVEWPTVARATVQALRLHGGRFPDDPGIIDLVSELSATSAKFRELWQDNEVENMARAFKVFVLPETGRIELTYQTFDVHDAPGQQLLVGVPEPGSASAAAIESLRTPAERGASTA
>NC_015957.1|WP_043236786.1|7430482_7431073_+|TetR/AcrR-family-transcriptional-regulator
MNASHSSAAASPARTRLLETASNVFYADGIRHVGVDRIIAEAQVTRATFYRHFPSKEDLVLAHVEQRDQQIRSAVTEAFRTTTDPEALLIMLMAGIGEEICGPGFRGCPFINAAAEYPDPEHPVRQAVQAHRSWFRQTVQNLVAAAGCPDSEHTTAVLVLLRDGAMAGGNLDDPASVRDHLMRTARAVLAEGRSVR
>NC_015957.1|WP_014059427.1|7429352_7430231_-|alpha/beta-hydrolase
MSRRHTQPARRSRRALLALAAATALAAAAVPTLAHGASGAGPAAVSAAGTSSHAATKPTVVLVHGAWADSSSWSPVIDRLQAQGYPVQALANPLRGLASDAAYVKSRIESIDGPVVLVGHSYGGAVISEAAAQEHNVKALVYAAAFAPAKGETVGALAAKDPGSHATPDALNPIPFDAGNGASGVDVYIKPDKYRDVFAGSLSARKANSLAAVQRPINAAALEETVTDAAWQDIPSWYLMTRQDHALPPATQRFMAERAHAHIAEVNAPHAVMLTRPDTVTSLILHAATATR
>NC_015957.1|WP_043240316.1|7443922_7444678_+|hypothetical-protein
MRFSVGDTVNAETTRNPLTFTPRFDFTDLQVIVAEYTDPKEREQHLAHTFGSMQWLWSEHDEFRFDQSSRELSHATFYVPRDSAPSPLCHRAPPEPQRLPGGLRTDTTQNFALPQATIFCCDPEAAELRCYRDLSVLDGEPDALIGIAPDVGLLVKGGAVAGWSLTDPARYLTDGFADPEATPPSHTTRLRLAECLNLVTAPLIDEVMDQDADTWRRLRAIERDLRDQRNDRNRATIMHRVISRLIEDNES
>NC_015957.1|WP_043240320.1|7445775_7446864_+|transposase
MIVSLVYQVTRKLLSVPAVLLRRQTARDAELLVLRHENAVLRRQLASPVRYQWTDRLWFAALSSLIPRRRWAQAFPVTPGTLLRWHRRLVARRWDYSECRTRPGRPATAEAVKELVLRLARENPRWGCRRIQGELARLGHKIGASTVWKILTAAGVDPAPRRSGPTWREFLTSQSEAIIACDFLHIDLASLRRVYALVFLEHGTRRLHIAGVTAHPTAQWTAQQARNLALEVGVRLESLRFVIRDRDSKYTESFDAVFEAEGIETLKTAPRPPRMNAHCERVIGTLRRELLDHVLIWNDTHARHVLDVYARHYNGHRPHQARGQRPPLTDSRTAPLTDSSTPRRLLQTRVLGGLINEYRHAA
>NC_015957.1|WP_014059443.1|7447250_7448081_-|AfsR/SARP-family-transcriptional-regulator
MDIGILGPLVVGANDREATPSAPKPRQLLALLAAHAGRVVPVDLMVDELWESTPPPSALTTVQTYIVLLRRLLAKSLQVSSAEVAREVLTYTGWGYQLAAGKGTHDASLFARYADLGRRALAAGDNSRASGALREALAFWRGPALADIRTGPHLLAHRVSLEEQRMGAVEQRIEADLRLGRHHELIGELSGLTVQHPLHENMHSLLMIALYRSGRPGQALETFQKLHQNLRNELGMEPSPNTRTVQQRILRRDSTMEADQQSKLFPQEIIPSRPTG
>NC_015957.1|WP_014043695.1|7449861_7450170_+|transposase
MPAPRKYPLELRDRAVRMYRAAEPKPVIRRMAEELGVHHEALRNWIRQAEADAGERGDILTTAEREELAALRKENAQLKRANEVLRTASAFFAAQLDPTRPR
>NC_015957.1|WP_106685742.1|7450816_7451089_+|IS3-family-transposase
MGSVGDSFDNALAENLWMVIKTECIRGRVFPTRAEANLTLFEYIDGFYNPRRIQKRLGYLSPIEYEEKHYASQATAEQVNLKPRQPSLTS
>NC_015957.1|WP_078505468.1|7451085_7452225_-|RNA-directed-DNA-polymerase
MRPESFLILRRHSAISSASRGSSVRMWSATCHPTIIREYICFGSLDHDVMLSILSEKIHDGRFLRLIGHMLKAGYLEDWRWDATLSGAPQGGVASPILSNIYLDRLDQFVEQSLLPEYNRGRRRQPNRAYRRLEHWIQGARRRGDWKSVRELEPRRRALPSQDPNDPDYRRLRYVRYADDWLLGFAGPRHEAEEIKSKVRTFLQEELKLELSEAKTLITHATRQAARFLGYEIKSQYSNDKITRNRRAVNGSIGLFVPRQAIRQRCALYMKKGKPALRGSVMRDDDFTIVAKYQSEFQGVVQYYLLAQDVFRLGRLRWVMETSMLKTLAGKHRSTVTKTARKYKRLIETPDGPRTCFQVTVERDRGRKLRFPRCTGVAD
>NC_015957.1|WP_167543240.1|7452118_7452547_+|transposase
MIVGWQVADHMRTELPLDALEMALWRRRIKKDSGLIHHSDRGSQYVSIRYTGRLADIGASASVGSVADSYDNAMAEALNGTFKAELIEMQGPWKDPAQVERAIFQWVTWYNEERLHSALDYVPPAECERDFWQSQEQTPQSA
>NC_015957.1|WP_014059446.1|7453272_7456038_-|LuxR-family-transcriptional-regulator
MLERDERLGRLTELIDRGDEETGTTGIISGAVGFGKTALLEVLVARAADRGYTVLSAAGSQVQRAFPYGVMEQLFLDAEVAGADMDLHASLQRVREAQEERSPLASEAGAAQAMQAYHGLLVELSAHRPVVLCVDDIQHADPESLACLLYLIGRCRRIPVTILLTLGPSGIAPYDGVLPELVCRPGVVHVKLGAFDPGDMARLIADRFGQAAAEQYTPGFYAMSGGNPLLVQALLSDHTARRAHPEEGYSPVAADLFREASVACTRRSGPNGLQVARGISIASGAGSPALLAQLVGLEKSEVESAMKILTESRLIEGLRFRHRAIRAAVLDNMSAADRRRLHHRAAGLLHNDGAPAIVVAQHLVAGGTAEDDWAPQLLMDAAGQALREDRVSLAGQCLQLADSCCHDRSLSHVIKANLARIKWRDQPEAAVRMMLSLVSPARTGDLPGAIRLEVAHCLLMQGRVSVAVEVVRPLFADQEDYLAPELDVTRLWLAVTYPAAYKQLVGGASSAPHLQAPSYQIGRPRLSAIHTLWAVLTRGADDMLAAEAERVLQHLPAEDETIISLNSAIAALIYADQLESAAAWCGQLQTAATERRAPTWHALFTSTRAMIALRRGSLRVAAESAETALLSMSVEAWGVEVGMPFATAIEARTAMGDHAAGAELVNSPVPNGLLETRFGLHYLYARGRHYLATGYYDAAIADFTLCGEKAQAWGLDSPTLAPWRIGAAEVWLHRGRRERASKLADEHLALVKRDQPRALGIALRVQAAARPPSQRIELLGTAMDMLQSAGDRYELALTLVELCRTHHRQGEAAQARLLVRQAWRMADECGAEGLSSSLVLKPVSVVQVEEPQSRPPADDVVTNMLSEAEMRVCSLAARGHTNREISDKLFVTVSTVEQHLTRAYRKLNIRHRRELPASLAS
>NC_015957.1|WP_014059449.1|7477923_7496430_-|type-I-polyketide-synthase
MNHEISGSDVAVIGMACRLPQAPGPADFWQLLRTGTNAIGDVPADRWPDRAGNDGHDDALRALVRRGGFIEEPDAFDAAFFGVSPRESAEMDPQQRLALELSWEALEDAGVVPESLRGLPVGVYVGAMASDHANLTSLRSPEAINHHTMAGTHRAVIANRISYFAGLRGPSMTVDTGQSSSLVAVHMACESLRTGESRLALAGGVNLNLTEQSALLEARLGALSPDGQCFTFDERANGYVRGEGGGFVVLKPLADALADGDDVYCVIRGSAVNNDGAGDSLLVPTVAGQREVLTRAYTRAGVAPGDVQYVELHGTGTKVGDPVEAEALGHSIGTGQDRDRPLLVGSVKTNVGHLEGAAGITGLLKVALMLKHREIPASLNFNRLNPGIRAAEWNLQVVTEPVPWPDPDGTLLAGVSSFGMGGTNCHVVLSSPVRNAVEPTPGAAPGELALVLSAKSATALRGQAERLLEQVTAEPSLNTADVAWSLIGSRSAFEHRAVVLGGGRDELTAGLAGLVSGEPAAGLVQGQAREDRRVAFVFPGQGAQWTGMASELMESSPVFRAAMEECAEALRPFVDWPLTDVLDDQAALERVDVVQPALWAVMVSLARLWRWMGVEPAAVVGHSQGEIAAACVAGGLPLAEGARVVALRSRAIAEALTGRGGMAVVSLPAQEAAELIAPWDGRLSIATVNGPGSVAVSGETEAIEELAAQCADSGIRVRTVSVDYASHSAAVEEIESRLLADLEPLRPRSGTVPMYSSVTGAPVDTAGLDARYWYRNLRQTVQFETATRALAADGISVLVEVSPHPVLTVPVQDTLDSLDGPDGKEAVVTGSLRRDEGGLDRFLTSVAQVHVQGVPVSWTSLFEGRQPRRVKLPTYAFQRDRHSVLGLGQGPARLLEAEPVAALASADEDDAFLRKLAPLSPKERDSHLLSVVRDHAAALLGHRGGDDVDPTVPFRAAGFDSMTAVDLRNRLQTVTGLAIPSSMVFDYPTPARLAAFLAGRLGGTESADDTVVPSAAPLDDDPMVIVGMSCRFPGGVADPEQLWDLVIGERDAITGFPTDRDWDLEHLYGPDTAGRLAGGFVDGAMDFDAGFFAMSPREALAMDPQQRLLLEGSWEALEHAGIDPVSLAGSATGVFVGSYQSGYSEVVSAALADADAQLLTGGAQSVLSGRVAYSLGLVGPAVTVDTACSSSLVALHLAGQALRGGECSLALVAGVTVNALPHTFVGFSQQGGLSADGRCKAFAEAADGTGFSEGAGVVVVERLSDARRNGHRVLAVVRSSAVNQDGASNGLTAPNGPSQQRVIRQALAAAGLDSGDVDAVEAHGTGTSLGDPIEAQAVLATYGQDRPDDRPLWLGSVKSNLGHSQAAAGVAGVIKMVLAMRRGVLPRTLHVDEPSTHVDWSQGRVRLLTQEQPWPETGRPRRAGVSSFGISGTNAHVILEAAPGLGTEPEAETAVEDGAETVWVVSARSEQALRGQAERLVSAVESLEPAGVGAALLSRSLFDHRAVVVGADRDELRAGLRAVAAGEPVANAVEGVARPGGRVAVLFAGQGAQRLGMGRRLYGESGVFAAAFDEVVAELDRHLESPLRDVIWGEDAEVLNATGWAQPALFAVEVALFRLLQSFGVVPDYLLGHSIGEVAAAHVAGVFELADACRLVVARARLMQALPAGGAMVAIAAPEEEVLPYLSEDVSIAAVNAPGSVVISGARAAVMEVGEHFTAQGVKTTRLRVSHAFHSVLMEPMLDDFMAEIADVSFSEPRIPVVSNLTGEPADMSSPGYWARQVRSAVRFADGLAWLAGQGVDTFVDAGPDGVVAGLAQANAAGAVAVALMRKDRDGLRTALVAAGDLFVRGVPVAWDTLFAGSTPRWVDLPTYAFQRRRYWPQASIAGGDVTAAGLASAGHPLLGAVVSVPNSGTVVLTSRLSLRTQPWLADHAVHGTVLFPGTGFVELAIRGADAVGAGGLRELIVEVPLVIPESDSVQVQVVVDDGTAVIYSRPADDDPWTRHATAVLGDALAAEPDGWQWPPADASWVDLSGFYELTADSGLVYGPAFQGLRQVWQADGAAFAEVAVAENEADRARKFGVHPALLDAAVQASAYAELDPAPAGRVPIGFADVTLHAEGATATRVRVARTGPDSVSVQLADGNGDAVLSIGSVTLGAPPTSGLSAASQSGTALALDWPELPAPEDHADVRLAFVQAPASDASWLPETAYTNLEDVLAEENPPQYVTLAVSVGEPDDMVRAVHATTRWALEQLQSWLAEERFADTTLVVLTRGAIAAHHDEPVPDLGAAAVWGLLRTAQMEHPGRILLVDAEPRHDLDVRQLAMALRTGEPQLALRGQEIRAARLARVTPRDEPEPRVDPEGTVLVTGGTGGLGREMARHLVAAHGVRSLLLLSRRGTAAGGAQELIDELSAQGAEVTVAACDVGDRAALAAVLAGTTLTGVVHTAGVVDDGLVSSLTAERLDRVLVPKVDAAWALHELTAGMDLSFFAVFSSLSGILGNPGQANYAAGNVFLDALMQARRHAGLPGVSMAWGAWTQDVGLTAALSEADMRRLARSGMRPLSVPQGLALFDRALVSDRALLGLASLDLAALRARDDLPVFRSLVGGRARRRAGDQRQPAGGLAERMAGLPEPEREDYLLTLIRDHAAAVLGHASGQHLNVTTAFREMGFDSLMGIELRNRIKRGTGLPVADSMVYDYPTPLRLAQYLASLVGGVELRVGGAAQARVLADDDRLAIVGMACRFPGGVTNPDELWKLIAEGGDAIAAFPDDRNWDIEQLYDAEGARSGSSVTRSGGFIDADGFDSTFFGISPREALAMDPQQRLLLESSWEALEDAGIDPQSLAGSSTAVMFGISQSGYGELVSPLEEAQGHLLTGGAFSVASGRVAYTLGLEGPAVTVDTACSSSLVALHLAGQALRAGECSLALAGGVTVMATPGTFVEFSRQGGLSSDGRCKAFADTADGTGWSEGLGVVVVERLSDAERNGHQILAVVRASAVNQDGASNGLTAPNGPSQQRVIRQALAAASLAPSDVDVVEAHGTGTTLGDPIEAQAVLATYGQDRPDDRPLWLGSLKSNIGHTQAAAGVAGVIKMVLAMRHGVLPQTLHVDEPSSRVNWSQGRVRLLTESVAWPETGRPRRAGVSAFGMSGTNAHVILEAPAEIEAEAEPESGALPPAVAWVVSARTDQALRGQAERLLSAVVESAEPVDVGAALLSRSLFDHRAVVVGTDRDELASGLQALAGGEPAANVANGVARAGQGRRVVFVFPGQGAQWVGMAGGLVDSSEVFRESMAECAEALAPFVDWSLLDVLEDEAALARVDVVQPALWAVMVSLARVWRSWGVEPAAVVGHSQGEIAAAVVAGGLSLSDGARVVALRSQAIAGVLAGQGGMVAVSLPVDEVRELLPEGVSVAVVNGPGAVVVAGPVEALDGVIARCEEREVRARRVPVDYASHSASVELIEDRLAADLAGLAPVSSSVLMYSSVSGTPIDTAGLDAGYWYRNLRQTVEFEQATRALAADGFTAFVEVSPHPVLTMALQDTVGEDAAVTGTLRRNEGGLERFLLSAAELFVRGVPVAWDGLFAGRTSGRVELPTYAFQRRRFWPQPSLVAGDVAAAGLVSVEHPLLGAVVSVPGSGTVVLTSRLSLRAQPWLVDHAVHGTVVFPGTGFVELAIRGADAAGAGRLRELIVEAPLVIPERDSVQVQVVVDGDDHTVGIYARTGEDEPWTRHATGVVDDETAAVDAGELAGAWPPPGSTPVDLDDFYQRSADNGFGYGPVFQGLTRAWQHNGQIFAEAALPDDQGAAAIAFGIHPALLDSALHPNTFADLDATELGRLPFTFNDVTLHATGAKAVRIRMARTGPDSVTAVLADETGAPVLSIGSLIMRPVPEQVFGAARTPETMLALAWNEVPETDGVASASDDDVLLEVPAAADTTPESVHTAVEWVLTQLQGFTGNRLVVLTHGAVAAGPGETVADLAAAAVWGLVRSAQSEDPGRIVLVDADADTQATPELLARAAGTGEPQLAVRAGTLLAPHLTRTNATGEPVTLDGTVLITGGTGGLGSAVARHLVAAHGVRSLLLLSRRGAAAPGADALVEELTAQGAEVKVVACDAADRSALADVLAGVPLTGVIHTAGILDDGVISTLTPEQVHRVLTPKVDAAWHLHDLTRDQDLSMFVVFSSLAGLIGSPGQGNYAAGNVYLDSLVQQRRSAGLAGISMAWGPWDQSLGLTGALSGTDMHRLGRLGMLPISEDQGMILFDRALAAGQPLLGLTELKTSALRATAEIPALFRSLAGGPARRTRARAGVAERTGGLAGQLADLTPEQRQSHLLALVRDQVASVLGYQSGTDIDESKPFREVGFDSLTAVELRNRLQTVTELSLPSTLVFDYPNAVRLADFLGERLGGVAAVPVDALPVLRSVEEDPLVIVGMSCRFPGGVADPEQLWDLVIGERDAITGFPTDRGWDLEHLYGPDTAGRLAGGFVDGAMDFDAGFFAMSPREALAMDPQQRLLLEGSWEALEHAGIDPVSLAGSATGVFVGSYQSGYSEVVSAALADADAQLLTGGAQSVLSGRVAYSLGLVGPAVTVDTACSSSLVALHLAGQALRGGECSLALVAGVTVNALPHTFVGFSQQGGLSADGRCKAFAEAADGTGFSEGAGVVVVERLSDARRNGHRVLAVVRSSAVNQDGASNGLTAPNGPSQQRVIRQALAAAGLSPTDVDAVEAHGTGTTLGDPIEAQAVLATYGQDRPEDRPLWLGSVKSNIGHSQAAAGVAGVIKMVLAMRRGVLPRTLHVDEPSTHVDWSQGRVRLLTQEQPWPETGRPRRAGVSSFGISGTNAHVILEAVPAVEPEVEAGGDGGSVWVVSGRTQQALRGQAERLVSAVESLEPAGVGAALLSRSLFDHRAVVVGADRDELRAGLRAVAAGEPVANAVEGVARPGGRVAVLFAGQGAQRLGMGRRLYGESGVFAAAFDEVVAELDRHLESPLRDVIWGEDAEVLNATGWAQPALFAVEVALFRLLQSFGVVPDYLLGHSIGEVAAAHVAGVFELVDACRLVVARARLMQALPAGGAMVAIAAPEEEVLPYLSEDVSIAAVNAPGSVVISGARAAVMEVGEHFTAQGVKTTRLRVSHAFHSVLMEPMLAEFTSAIADVTFSLPQIPVVSNLTGEPADMSSPGYWARQVRSAVRFADGLAWLAGQGVDTFVDAGPDGVVAGLARTDAAGAVAVALMRKDRDGLRTALVAAGDLFVRGVPVVWDELFGGRKPGRVDLPTYAFQRRRYWPQASIAGGDVTAAGLASAGHPLLGAVVSVPNSGTVVLTSRLSLRAQPWLADHAVHGTVLFPGTGFVELAIRGADAVGAGGLRELIVEVPLVIPESDSVQVQVVVDDGTAVIYSRPADDDPWTRHATAVIDPEGSPAGNAVAWQWPPMDAAQADVADFYQSLADDGFAYGPVFQGLRQVWVGPEEVFAEVTVADEEADRARKFGVHPALLDAALQASTFVGLEPAPAGRMPFSFTDVTLHAGGATATRVRVVRTGPDSVSVELADGSGEPVLTIGTLVLQPVTATGPVGDAQAGSVLTVDWSSTITLDDDPAPGADLQVVGAPNDIVLDDIDPAAVVVLEASGSGDVPQSAHHLTGWVLTQVQRWLADERCADGRLVVVTRGAVATVPGERVGGLAASAVWGLVRSAQAENPGRITLLDIDDQTAQLDAGFVARAAVSAEPQLVVRDGVVGAARLVRVAAAPEQEPVGFGEGRVLVTGGTGGLGREVARHLVRAHGVRDLLLVSRGGGGADLVAELEELGARAVVAACDVSDREALATLLEGVDLSAVVHTAGVVEDSVVTSLDGARLDRVLAPKVDAGWYLHELTADRDLSAFVVFSSLAGMLGSPGQGNYAAGNVFLDTLMEQRRAQGLPGVSMAWGPWAQGAGLTSGLSETDMRRISQSGTPPFTVEQGLRMFDEALAVPRAAVAVTRLDLGALRGRADLPPLWRALTGKRARPAAADRRQDAGTLADRLAGLAIPERTEQLLVLVREHVAAVLGYASREHIDTNQAFRELGFDSLSALELRNRLQVATGLTIPATLVFDYPNSQRLATHLAGQFGTAESTDTGAASLLSQMDTLSGALKRAELVDGEREAIANRLRSMLDAWRASDEEDPDEEWETPDEVFRFIDDELGISEREV
>NC_015957.1|WP_014059450.1|7497018_7497927_-|alpha/beta-hydrolase
MPLDPSVKAVLDILDAAGDKQLYELPIPVARAAYDQLAGFGGEPAAVGRTEHTSADGVPVRLYWPESPGPHPVLLFVHGGGWMLGSLDGYDGVARDLSVHADCLVVSVGYRIAPGNCFPAAVEDVVTAAKWVMRTGESFGGDVSRLAVAGDSAGGNLSAVLVNELPGRFRAQALLYPATDQTRQHPSVRENGQGYLLTEGTLRWFSENYLGDQDPRHPWASPLYAADEVLAAAPPTLVVTGEFDPLRDEGEAYAARLRALGVRVEHRRYDGMIHAFFSMRGMVPAAGEALRQVTDFLQDAWA

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Crispr_ID: NC_015957_16

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015957_16

7923350-7923442

Orphan

Consensus_repeat	Method
TCACGGCCTGACGAGCGCCGGTTGTGGCCC	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of NC_015957_16

>merge|NC_015957|16|7923350-7923442|CRISPRCasFinder
TCACGGCCTGACGAGCGCCGGTTGTGGCCCAACGGGCGCCCGTTCCCGCCTGACGAGCGCCTCTCACGGCCCGACGAGCGCCGGTTGTGGCCC

>NC_015957|16|15|7923350-7923442|CRISPRCasFinder
TCACGGCCTGACGAGCGCCGGTTGTGGCCC	AACGGGCGCCCGTTCCCGCCTGACGAGCGCCTC
TCACGGCCCGACGAGCGCCGGTTGTGGCCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015957.1\|WP_014059777.1\|7933852_7934047_-\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014059758.1\|7914553_7915972_+\|tyrosine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235645
NC_015957.1\|WP_014059757.1\|7913091_7914486_+\|peptidase	unknown	unknown	gnl\|CDD\|223389
NC_015957.1\|WP_014059773.1\|7928407_7930189_+\|glycoside-hydrolase-family-15-protein	unknown	unknown	gnl\|CDD\|225922
NC_015957.1\|WP_150112940.1\|7925175_7926087_+\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_043236895.1\|7932032_7932587_-\|alkaline-shock-response-membrane-anchor-protein-AmaP	unknown	unknown	gnl\|CDD\|380217
NC_015957.1\|WP_043236893.1\|7927238_7927472_+\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014059762.1\|7917510_7918500_-\|GTP-3',8-cyclase-MoaA	unknown	unknown	gnl\|CDD\|234672
NC_015957.1\|WP_014059759.1\|7916129_7916420_-\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	unknown	unknown	gnl\|CDD\|225170
NC_015957.1\|WP_014059774.1\|7930193_7930949_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187602
NC_015957.1\|WP_014059772.1\|7927550_7928360_+\|SURF1-family-protein	unknown	unknown	gnl\|CDD\|119401
NC_015957.1\|WP_050994035.1\|7921267_7922746_+\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173799
NC_015957.1\|WP_014059768.1\|7924104_7925055_-\|sterol-desaturase-family-protein	unknown	unknown	gnl\|CDD\|225546
NC_015957.1\|WP_014059763.1\|7918604_7920224_-\|cation-acetate-symporter	unknown	unknown	gnl\|CDD\|271374
NC_015957.1\|WP_014059778.1\|7934087_7934606_-\|Asp23/Gls24-family-envelope-stress-response-protein	unknown	unknown	gnl\|CDD\|377129
NC_015957.1\|WP_014059760.1\|7916646_7917036_+\|DUF3099-domain-containing-protein	unknown	unknown	gnl\|CDD\|378630
NC_015957.1\|WP_014059756.1\|7911559_7913095_+\|TldD/PmbA-family-protein	unknown	unknown	gnl\|CDD\|223389
NC_015957.1\|WP_014059770.1\|7926188_7927175_+\|DEDDh-family-exonuclease	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|180377
NC_015957.1\|WP_078505485.1\|7920220_7920643_-\|DUF485-domain-containing-protein	unknown	unknown	gnl\|CDD\|377315
NC_015957.1\|WP_014059761.1\|7917229_7917466_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_015957.1\|WP_014059758.1\|7914553_7915972_+\|tyrosine--tRNA-ligase	gnl\|CDD\|235645	PRK05912, PRK05912, tyrosyl-tRNA synthetase; Validated.	1.30278e-124
NC_015957.1\|WP_014059757.1\|7913091_7914486_+\|peptidase	gnl\|CDD\|223389	COG0312, TldD, Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only].	1.01914e-41
NC_015957.1\|WP_014059773.1\|7928407_7930189_+\|glycoside-hydrolase-family-15-protein	gnl\|CDD\|225922	COG3387, SGA1, Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism].	5.12348e-130
NC_015957.1\|WP_043236895.1\|7932032_7932587_-\|alkaline-shock-response-membrane-anchor-protein-AmaP	gnl\|CDD\|380217	NF033218, anchor_AmaP, alkaline shock response membrane anchor protein AmaP. The founding member of this family, AmaP (Asp23 membrane anchoring protein), is related to Asp23 through part of its length, but includes a highly hydrophobic N-terminal region that should make it an integral membrane protein. Asp23 (alkaline shock protein of 23 kDa), described in PMID:7864904, is a cytosolic protein in Staphylococcus aureus, strongly induced by a pH shift from 7 to 10, and also recruited to the membrane. AmaP appears to be the partner protein with an integral membrane segment and the ability to anchor Asp23 to the membrane. This model was built to identify full-length homologs of AmaP, while excluding Asp23. Some but not all members of this family score above the cutoffs of Pfam model version PF03780.11, but full-length homologs of Asp23 score considerably higher. Asp23 family members previously were known as DUF322.	6.66632e-20
NC_015957.1\|WP_014059762.1\|7917510_7918500_-\|GTP-3',8-cyclase-MoaA	gnl\|CDD\|234672	PRK00164, moaA, GTP 3',8-cyclase MoaA.	7.16268e-180
NC_015957.1\|WP_078505485.1\|7920220_7920643_-\|DUF485-domain-containing-protein	gnl\|CDD\|377315	pfam04341, DUF485, Protein of unknown function, DUF485. This family includes several putative integral membrane proteins.	3.80072e-32
NC_015957.1\|WP_014059759.1\|7916129_7916420_-\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	gnl\|CDD\|225170	COG2261, COG2261, Predicted membrane protein [Function unknown].	0.000155285
NC_015957.1\|WP_014059772.1\|7927550_7928360_+\|SURF1-family-protein	gnl\|CDD\|119401	cd06662, SURF1, SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring complex of the respiratory chain, is an assemblage of nuclear and mitochondrially-encoded subunits. Its assembly is mediated by nuclear encoded assembly factors, one of which is Surf1/Shy1. Mutations in human Surf1 are a major cause of Leigh syndrome, a severe neurodegenerative disorder.	1.62918e-44
NC_015957.1\|WP_050994035.1\|7921267_7922746_+\|S8-family-serine-peptidase	gnl\|CDD\|173799	cd07473, Peptidases_S8_Subtilisin_like, Peptidase S8 family domain in Subtilisin-like proteins. This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	3.13284e-59
NC_015957.1\|WP_014059768.1\|7924104_7925055_-\|sterol-desaturase-family-protein	gnl\|CDD\|225546	COG3000, ERG3, Sterol desaturase [Lipid metabolism].	2.00002e-36
NC_015957.1\|WP_014059760.1\|7916646_7917036_+\|DUF3099-domain-containing-protein	gnl\|CDD\|378630	pfam11298, DUF3099, Protein of unknown function (DUF3099). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.	1.48718e-21
NC_015957.1\|WP_014059774.1\|7930193_7930949_+\|SDR-family-oxidoreductase	gnl\|CDD\|187602	cd05344, BKR_like_SDR_like, putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR. This subgroup resembles the SDR family, but does not have a perfect match to the NAD-binding motif or the catalytic tetrad characteristic of the SDRs. It includes the SDRs, Q9HYA2 from Pseudomonas aeruginosa PAO1 and APE0912 from Aeropyrum pernix K1. BKR catalyzes the NADPH-dependent reduction of ACP in the first reductive step of de novo fatty acid synthesis (FAS). FAS consists of four elongation steps, which are repeated to extend the fatty acid chain through the addition of two-carbo units from malonyl acyl-carrier protein (ACP): condensation, reduction, dehydration, and a final reduction. Type II FAS, typical of plants and many bacteria, maintains these activities on discrete polypeptides, while type I FAS utilizes one or two multifunctional polypeptides. BKR resembles enoyl reductase, which catalyzes the second reduction step in FAS. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	5.6624e-68
NC_015957.1\|WP_014059763.1\|7918604_7920224_-\|cation-acetate-symporter	gnl\|CDD\|271374	cd11480, SLC5sbd_u4, Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain. SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.	0
NC_015957.1\|WP_014059756.1\|7911559_7913095_+\|TldD/PmbA-family-protein	gnl\|CDD\|223389	COG0312, TldD, Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only].	2.35546e-96
NC_015957.1\|WP_014059770.1\|7926188_7927175_+\|DEDDh-family-exonuclease	gnl\|CDD\|180377	PRK06063, PRK06063, DEDDh family exonuclease.	4.48696e-164
NC_015957.1\|WP_014059778.1\|7934087_7934606_-\|Asp23/Gls24-family-envelope-stress-response-protein	gnl\|CDD\|377129	pfam03780, Asp23, Asp23 family, cell envelope-related function. The alkaline shock protein Asp23 was identified as an alkaline shock protein that was expressed in a sigmaB-dependent manner in Staphylococcus aureus. Following an alkaline shock Asp23 accumulates in the soluble protein fraction of the S. aureus cell. Asp23 is one of the most abundant proteins in the cytosolic protein fraction of stationary S. aureus cells, with a copy-number of >25000 per cell. A second Asp23-family protein, AmaP, which is encoded within the asp23-operon, is required to localize Asp23 to the cell membrane. The overall function for the family is thus a cell envelope-related one in Gram-positive bacteria.	5.30941e-35

>NC_015957.1|WP_050994035.1|7921267_7922746_+|S8-family-serine-peptidase
MALTTALAFLPTTATALGRDGHAAAATAADGPSLSYVVNTRPGQDPSRIRKAIAQAGGTVVVSYDRIGVIVVHSANPDFAKSVRKVRGVASAGNTRTAPLPAQSTDDIDTPKLLSEKERQAVAAKAKAGQDPLEPLQWDLPAIKADKAHEKSLGSRNVTVGVIDTGVDDTHPDLAPNFDRKASVNCVTGKPDTADGAWRPTAQESPHGTHVAGEIAAAKNGIGVTGVAPGVKVSGIKVSTTAGFFYTEAVVCGFIWAAEHGVDVTNNSYYTDPWYFNCTTDPDQKALVEAVRRASSYAERKGVVNVAAAGNENYDLTSDTITDPSSPNDTTPGDREVDPSVCLDIPTQLPGVVTVASTGAKNLKSSFSNYGLGIIDIAAPGGDSTIYQKPEPPATSGLIYNTLPGGQYGYMAGTSMASPHVAGVAALVKSTHPHASPWQVKALLKAEADDLACPTPYDIDGDGTVDAVCEGGKRYNGFYGAGLADALDAVEK
>NC_015957.1|WP_078505485.1|7920220_7920643_-|DUF485-domain-containing-protein
MRDLDHLRRRIRPRRTHSPGETVDTAPANDRPDDQRQRDRSSYAEVQASAEFGELRGTHRSFAFPLTIAFVSWYLLYVLLSNYAGDFMGAKVVGHVNVALVFGLAQFLTTFLIAWWYSRHAAAKLDPRAEAIKSRMEERS
>NC_015957.1|WP_014059763.1|7918604_7920224_-|cation-acetate-symporter
MSFHLLAAESASDNRPLIITLFTVFVLATLGITIWAGRQTKDANDFYAGGRQFTGFQNGLAISGDYMSAASFLGIAGAIALSGYDGFLYSIGFLVAWLVALLLVAEPLRNSGRYTMGDVLAYRMRQRPVRTAAGISTIVVSIFYLLAQMAGAGVLVSLLLGITSEAGKILIVVLVGVVMMLYVTIGGMKGTTWVQMVKAVLLIAGTLLITFLVLLKFNFNISDLLGEAAKNSGIGESFLEPGLKYGLNATTKLDFISLGIALVLGTAGLPHILIRFYTVPTAQAARKSVNWAIGIIGVFYLMTIALGFGAAALLDHDAIIASNKSGNTAAPLLAEEIGGGADSTGGAILLAVISAVAFATILAVVAGLTLASSSSFAHDLYANVIRKGQATQKEEISAARWATVGIGTVAVVLGVFARDLNVAGLVALAFAVAASANLPTILYSLFWKRFTTQGALWSIYGGLISSVFLVLFSPVVSGKETSMFPDVDFHWFPLENPGLISIPLGFLLGWLGTLVSKEQPDKDKYAELEVRSLTGHGAH
>NC_015957.1|WP_014059762.1|7917510_7918500_-|GTP-3',8-cyclase-MoaA
MLIDTYGRVATDLRVSLTDRCNLRCTYCMPEEGLQWLAKPDLLTDDEIVRLIGIAVTELGVTEVRFTGGEPLLRPGLVGIVERCAALTPRPQMSLTTNGIGLQRTAQALRDAGLDRVNVSLDTLRPEVFQALTRRKRHDDVLRGLDAARTAGLTPVKVNTVLMPGLNDDEAPDLLAWALENDYELRFIEQMPLDAQHGWKRDGMITAGDILTSLRTRFTLTTEGEDERGSAPAERWLVDGGPARVGVIASVTRPFCRACDRTRLTADGQVRTCLFAREESDLRGALRSGAADEEIARLWRLAMWGKKAGSGLDDPSFLQPDRPMSAIGG
>NC_015957.1|WP_014059761.1|7917229_7917466_+|hypothetical-protein
MNTRETSAETDTVICSAKGCRAPAVWVLAWNNPKIHTPERRKTWLACEEHREYLSEFLGMRGFLKDVVTLAEWSATDH
>NC_015957.1|WP_014059760.1|7916646_7917036_+|DUF3099-domain-containing-protein
MRKHGDAEVFRITGARQGLADDVRGRQRRYVISMSVRTLAVVLAAVLWNVERHVAIVALVLGVVLPYISVVIANAGRENATSLPTTFIPTPPRPMLIAGRGEEPTDSRGAESVPEDVGHISEPGRGERG
>NC_015957.1|WP_014059759.1|7916129_7916420_-|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein
MNWLWAIVVGLILGVIARAILPGKQAIPLWLTCIYGILGGMLGNAVAGWIGVRTTGGFDWIRHLLQLAFAVVIVALGTPLWHSIRGGGRRHGAERT
>NC_015957.1|WP_014059758.1|7914553_7915972_+|tyrosine--tRNA-ligase
MTRLGESVARATELLSQDLSSDKTVEQLLEETGSRRYIDLTDLSPTEQAELIASRTVEILPGVAELAKRIEERRGAGQGLGIKLGIDPTAADVHLGHVVPMIILSRFQRMGHDVTLLIGDFTAKIGDPSGRTAERPPLTDEDIARNLAGYQDQVRPFFDFEKVSFRQNSEWLAPYTFPELLGLLSQVPVSQLLQREDFRNRLAAGSGLTMSELLYPIAQALDSVALECDVELGGADQLLNLQMGRKLMELRGQRPQLVVTMPLIEGTDGTGAKMSKSKGNYVALSATADDVFGKIMSIPDRLMKPYLEAWTEWTDAEIAAATARVEDRSLHPMDLKKVLAGEVVAALYGIEKAMAARAGFVAQFSKKSFTDVETLPVVDAGEHGAESIATVLSKVLEFQPSASAARRVAKQNGLRLVIETEGGQESVVLPEAQAVRPLAEVVAETLASTGVTAGSGTVYLKAGRKIAQVRGV
>NC_015957.1|WP_014059757.1|7913091_7914486_+|peptidase
MSVKPHEIVERALELSRADGCVVIANESSTANLRWAGNALTTNGVTRGRTLTVVATVNGGQGTASGVVSRSAVTADELEPLVRAAEAAAREAEPAEDAQPLVERDAVSAVSPGFTDSPAVTSSEVFADFAPALGESFARARAGGRELYGFAHHGLVSSYLGSSTGLRLRHDQPTGTLEINAKSPDRTRSAWAGRATRDFTDVDPAAIDAELARRLAWAERRIELPAGRYETLLPPSAVADLLIDQLWSSSARDAAEGRTVFSKPGGGTRVGEKLSELPLTLRSDPAEPGLEAAPFVIAHSSGDDASVFDNGLPLSATDWIRDGVLQHLITTRHTAGLTGLPLAPPVDNLIADAGGTRSLDEMVASTERGLLLTCLWYIREVDPATLLLTGLTRDGVYLVENGEVVGEVNNFRFNESPVDLLARATEAGRTERTLAREWGDYFNRAAVPALRIPDFNMSSVSKGV
>NC_015957.1|WP_014059756.1|7911559_7913095_+|TldD/PmbA-family-protein
MAHEIDPSFLALPLRALADAALARARALGAEHADFRFERVRSAAWRLRDARPSGASDTTDLGYAVRVVHGGAWGFASGVDLSMDAAARVASQAVAMAKLSAKVIEAAGSDERVELAPEPVHADKTWVSSYEVNPFEVPDADKTGLLAEWSERLLRAEGVAHADASLLTIHENKFYADTAGTATTQQRIRLHPQLTAVAVDPASGEFDSMRTLAPPVGRGWEYLTGGPGAGGWDWDAELAEIPELLAEKMRAPSVEAGSYDLVVDPSNLWLTIHESIGHATELDRALGYEAAYAGTSFATFDQLGSLKYGSQVMNVTGDRTAEHGLATIGYDDEGVAAQSWDLVKDGTLVGYQLDRRIARLTGFERSNGCAFADSPGHVPVQRMANVSLRPAPGGPSTEELIGDVENGLYLVGDRSWSIDMQRYNFQFTAQRAFRIRNGALAGQVRDFAYQATTTDFWGSMTAVGGPQTYVLGGAFNCGKAQPGQIAAVSHGCPSALFRGVNILNTTQEAGR
>NC_015957.1|WP_014059768.1|7924104_7925055_-|sterol-desaturase-family-protein
MPHLPNAVLWSIPAFVLLTVVEMVSYRFHPDDDAEGYAAKDAATSVTMGLGSLVFDLVWKIPIVAIYAAIYELTPLRVPVLWWTLPLMLLAQDFFYYWSHRGHHVIRILWACHVVHHSSRNFNFTTALRQPWTTWTVWPFYVPMIALGVHPAAVAFCSSVNLVYQFWIHTERIGTLPRPIEFLFNTPSHHRVHHASQGGYLDRNFGGILIVWDRLFGSFVPEIERPVYGLTKNIDTYNPLRVATHEYAAIARDIAAARGWRERAGRAFRGPGWQPGPVPEGGSAPEPGSATEAGPAPEAGPPPEAGPREPVGESVR
>NC_015957.1|WP_150112940.1|7925175_7926087_+|hypothetical-protein
MRSARERFRTGGIALACLLSALTTGCSSGSGDDDSSSPLMAAVGHISVAGATGAQVSYLDAGRVRSLEKGDSQRFRTVGQAGSPLLSGYRFNAHAYGLDPAMIDTDVTNGYAGHWDGSFDADGITAKLKAGGFARSIWHGETIWKKEGITLQVAQDGLSFGFAGKDLSSVRPAKGKSLADDPDYQALDRCLGDAYRVDFGGKNAEDAKNTVRLSATGQLAKSAKETSGVICALTDGKRTAERAADRLKSVIEQRAPRFDGAKVTVLTGDSPGVKVTVPDRPGDKRAGRILTSDIDLQLALSKL
>NC_015957.1|WP_014059770.1|7926188_7927175_+|DEDDh-family-exonuclease
MLEDPTTAAPHPAPPSSWPATYPQGYAVVDVETTGLARDDRIVSAAVYQLDARGAVQDHWYTLVNPQRDPGPVWIHGLTEEVLEGAPRFPEIAGELAERLADRVLVAHNAAFDWSMLAREYARSKSAAPVRQRLCTIALSKELGLPLPNHKLETLAAHYGVVQRRAHHALDDARVLAETFRPSLHRAAETGLRLPLLACQPLTEWSDGPTIGRQRSYRQTWRPSRKRPACPYPNPGRYEPGGQLVQGMRVAFSGDTSVDRELLEDRAIEAGLHVATSVSRLTSVLVTNDPDSPTSKTAKARSFGTPVIDEAAFMQLLQDVTPAPPTNR
>NC_015957.1|WP_043236893.1|7927238_7927472_+|hypothetical-protein
MARCEVCGNDYRMTFEVHAQGNVHVFDCFQCAIHRMAPICEHCRAQIIGQGVEADGQFFCCAHCARAEGKVGIVDHV
>NC_015957.1|WP_014059772.1|7927550_7928360_+|SURF1-family-protein
MYRFLLTRQWVILTLIALALIPTMIRLGFWQLHRHEHRVAQNQLIGDSLAAPAVAVDKLTSPGRTVARDDTWRTVTATGTYDTAHEVVARQRTGSDEQSIGYFVLTPLLLPDDRAVLVNRGWIPAGADLTAFPKVPAAPSGKVTVTGRLKADETTGNSGIKDKQGLPPRQVSLINSEQQAKALSRPVLGGYIELTSSSPKGDKQPQPVPAPNHSDIGPHMAYAVQWWLFSAGVPIGWVVLARRERRDRAAEAVKAAATPEKVPAAATAD
>NC_015957.1|WP_014059773.1|7928407_7930189_+|glycoside-hydrolase-family-15-protein
MVQHIDDYALIGDHQTAALISRHGSIDWLCLPRFDSAACFAALLGGRDNGHWRLAPKGAGACTRRGYLDDSLVLESVWETETGTVKVIDFMPQRDRAPDVVRIVEGVSGSVEMLGVLRLRFDYGRIVPWMRRTDGHRIAIAGPDSVWLRSEPEVHTYGKDFSTRSEFTVSTGDRVAFVLTWHPSHEPRPRLVDPYDSLRSSLADWRGWAARCRYEGPYRDAVIRSLITLKALTYAPSGGIVAAPTTSLPERLGGVRNWDYRYCWLRDSTLTLNALLRAGYHEEAAAWRDWLLRAIAGDPAELQIMYGLGGERRLPEHELPWLEGYEHSAPVRVGNGAVDQRQLDVYGEVLDTLHLARASGLPAEPHAWNIQTALMDFLESAWRDPDEGLWEVRGPRRHFVHSKVMAWVAADRAVRAMAAAPELSGDANRWRAMRDAVHREVCEKGYDPERSTFTQSYGSPELDAATLLIPRVGFLPATDPRVIGTIDAVRRELSEDGLIRRYTAADGMDGLPGSEGAFLACSFWLADAHHLAGRRKDARALFERLLALRNDVGLLAEEYDPATGRQLGNFPQAFSHIGLVGTALTLAERPRAD
>NC_015957.1|WP_014059774.1|7930193_7930949_+|SDR-family-oxidoreductase
MDLGLKDRVYIVTGATRGLGLAAARELIADGAKAVITGRDADTAAAVAADLGPNALGVAADNADPETAARLIATARERFGGFDGVLISVGGPPAGLTADITDAQWQAAFDSVFLGAVRFARTAAEQLPSGGVIGFVLSGSVREPIPGLTVSNGLRPGLAGFAKSLSLEVGPRGIRVVGLLPARIDTDRVRELDALSGDAEASRERNAAAIPLRRYGTPEEFGKAAAFLLSPAASYLTGLMLPVDGGALHNF
>NC_015957.1|WP_043236895.1|7932032_7932587_-|alkaline-shock-response-membrane-anchor-protein-AmaP
MLRVVNRVLLGVVGLVLAGVGAVVLAGWPPFDGRGDVLLSRADRTRWRDAGWWWPAVIAALAVLFVLALCWFLAQLRRRRLQEVLVETGDGEGALLRGRALEAALLADAESLDGVERAHVLLRGRRTTPEARMGLVLEPRAEPTLTLDALRAEALERARSSAGLDQLPAEVRLRVARHGAERAR
>NC_015957.1|WP_014059777.1|7933852_7934047_-|hypothetical-protein
MSMAVVGMIAGMALAFAGYFGGFGAFLLVAALGAVGFIVGRFLDGDLEPGEFFRSRGRDDGRPR
>NC_015957.1|WP_014059778.1|7934087_7934606_-|Asp23/Gls24-family-envelope-stress-response-protein
MSETAPRNRPENPATEPAAGTPRTLGARGGTAPAATDRPRRGGGDPGSRGRTTIADGVVEKIAGMAARDVVGVHAMGGGLARTFGVVRDRVPGTRSVARGVKAEVGEVQTALDLEIVVDYGVSIADVARAVRENVIAAVERMTGLEVVEVNIAVSDVKLPDEEEESPEPRLQ

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Crispr_ID: NC_015957_17

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015957_17

8056931-8057025

Orphan

Consensus_repeat	Method
GCGCCGGGCGCCCGCTCAGGCGTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015957_17

>merge|NC_015957|17|8056931-8057025|CRISPRCasFinder
GCGCCGGGCGCCCGCTCAGGCGTCAGGACCCTCAGCCACCGGGCGCCCGCTCAGCGTCAGGACCCGCTCAGGCACCGGGCGCCCGCTCAGGCGTC

>NC_015957|17|16|8056931-8057025|CRISPRCasFinder
GCGCCGGGCGCCCGCTCAGGCGTC	AGGACCCTCAGCCACCGGGCGCCCGCTCAGCGTCAGGACCCGCTCAG
GCACCGGGCGCCCGCTCAGGCGTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015957.1\|WP_014059891.1\|8065953_8066958_-\|TerC-family-protein	unknown	unknown	gnl\|CDD\|274743
NC_015957.1\|WP_014059893.1\|8069342_8069921_-\|TerD-family-protein	unknown	unknown	gnl\|CDD\|376767
NC_015957.1\|WP_014059885.1\|8057670_8058741_+\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_015957.1\|WP_014059894.1\|8070115_8072254_-\|excinuclease-ABC-subunit-UvrB	unknown	unknown	gnl\|CDD\|235395
NC_015957.1\|WP_014059882.1\|8053689_8054625_-\|RNase-adapter-RapZ	unknown	unknown	gnl\|CDD\|235450
NC_015957.1\|WP_014059877.1\|8046001_8047204_-\|phosphoglycerate-kinase	unknown	unknown	gnl\|CDD\|234613
NC_015957.1\|WP_014059883.1\|8054621_8056832_-\|excinuclease-ABC-subunit-UvrC	unknown	unknown	gnl\|CDD\|234792
NC_015957.1\|WP_014059889.1\|8063765_8064422_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293792
NC_015957.1\|WP_014059880.1\|8051693_8052683_-\|DNA-binding-protein-WhiA	unknown	unknown	gnl\|CDD\|273194
NC_015957.1\|WP_014059876.1\|8045219_8045996_-\|triose-phosphate-isomerase	unknown	unknown	gnl\|CDD\|234589
NC_015957.1\|WP_009718803.1\|8044326_8044662_-\|RNA-polymerase-binding-protein-RbpA	unknown	unknown	gnl\|CDD\|379162
NC_015957.1\|WP_014059890.1\|8064552_8065863_+\|MHS-family-MFS-transporter	unknown	unknown	gnl\|CDD\|340927
NC_015957.1\|WP_014059892.1\|8067181_8069170_-\|TerD-family-protein	unknown	unknown	gnl\|CDD\|132992
NC_015957.1\|WP_014059886.1\|8058737_8059688_+\|carbohydrate-kinase	unknown	unknown	gnl\|CDD\|238572
NC_015957.1\|WP_014059881.1\|8052673_8053693_-\|uridine-diphosphate-N-acetylglucosamine-binding-protein-YvcK	unknown	unknown	gnl\|CDD\|211689
NC_015957.1\|WP_014059875.1\|8044878_8045106_-\|preprotein-translocase-subunit-SecG	unknown	unknown	gnl\|CDD\|235881
NC_015957.1\|WP_014059887.1\|8059766_8062799_-\|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl\|CDD\|234734
NC_015957.1\|WP_014059878.1\|8047286_8048291_-\|type-I-glyceraldehyde-3-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|223135
NC_015957.1\|WP_014059879.1\|8048466_8051433_-\|zinc-carboxypeptidase	unknown	unknown	gnl\|CDD\|349432
NC_015957.1\|WP_043240596.1\|8063029_8063761_+\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	unknown	unknown	gnl\|CDD\|236578

Protein	Function_ID	Function_description	E-value
NC_015957.1\|WP_014059891.1\|8065953_8066958_-\|TerC-family-protein	gnl\|CDD\|274743	TIGR03718, R_switched_Alx, integral membrane protein, TerC family. Rfam model RF00080 describes a structured RNA element called the yybP-ykoY leader, or SraF, which may precede one or several genes in a genome. Members of this highly hydrophobic protein family often are preceded by a yybP-ykoY leader, which may serve as a riboswitch. From the larger group of TerC homologs (pfam03741), this subfamily contains TerC itself from Alcaligenes sp. plasmid IncHI2 pMER610 and from Proteus mirabilis. It also contains the alkaline-inducible E. coli protein Alx, which unlike the two TerC examples is preceded by a yybP-ykoY leader.	6.29895e-142
NC_015957.1\|WP_014059893.1\|8069342_8069921_-\|TerD-family-protein	gnl\|CDD\|376767	pfam02342, TerD, TerD domain. The TerD domain is found in TerD family proteins that include the paralogous TerD, TerA, TerE, TerF and TerZ proteins It is found in a stress response operon with TerB and TerC. TerD has a maximum of two calcium-binding sites depending on the conservation of aspartates. It has various fusions to nuclease domains, RNA binding domains, ubiquitin related domains, and metal binding domains. The ter gene products lie at the centre of membrane-linked metal recognition complexes with regulatory ramifications encompassing phosphorylation-dependent signal transduction, RNA-dependent regulation, biosynthesis of nucleoside-like metabolites and DNA processing linked to novel pathways.	1.49764e-55
NC_015957.1\|WP_014059885.1\|8057670_8058741_+\|LacI-family-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	3.44023e-119
NC_015957.1\|WP_014059894.1\|8070115_8072254_-\|excinuclease-ABC-subunit-UvrB	gnl\|CDD\|235395	PRK05298, PRK05298, excinuclease ABC subunit UvrB.	0
NC_015957.1\|WP_014059882.1\|8053689_8054625_-\|RNase-adapter-RapZ	gnl\|CDD\|235450	PRK05416, PRK05416, RNase adapter RapZ.	8.88255e-166
NC_015957.1\|WP_014059877.1\|8046001_8047204_-\|phosphoglycerate-kinase	gnl\|CDD\|234613	PRK00073, pgk, phosphoglycerate kinase; Provisional.	0
NC_015957.1\|WP_014059883.1\|8054621_8056832_-\|excinuclease-ABC-subunit-UvrC	gnl\|CDD\|234792	PRK00558, uvrC, excinuclease ABC subunit UvrC.	0
NC_015957.1\|WP_014059889.1\|8063765_8064422_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293792	cd06262, metallo-hydrolase-like_MBL-fold, mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases which can catalyze the hydrolysis of a wide range of beta-lactam antibiotics, hydroxyacylglutathione hydrolases (also called glyoxalase II) which hydrolyze S-d-lactoylglutathione to d-lactate in the second step of the glycoxlase system, AHL lactonases which catalyze the hydrolysis and opening of the homoserine lactone rings of acyl homoserine lactones (AHLs), persulfide dioxygenase which catalyze the oxidation of glutathione persulfide to glutathione and persulfite in the mitochondria, flavodiiron proteins which catalyze the reduction of oxygen and/or nitric oxide to water or nitrous oxide respectively, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J which has both 5'-3' exoribonucleolytic and endonucleolytic activity and ribonuclease Z which catalyzes the endonucleolytic removal of the 3' extension of the majority of tRNA precursors, cyclic nucleotide phosphodiesterases which decompose cyclic adenosine and guanosine 3', 5'-monophosphate (cAMP and cGMP) respectively, insecticide hydrolases, and proteins required for natural transformation competence. The diversity of biological roles is reflected in variations in the active site metallo-chemistry, for example classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, human persulfide dioxygenase ETHE1 is a mono-iron binding member of the superfamily; Arabidopsis thaliana hydroxyacylglutathione hydrolases incorporates iron, manganese, and zinc in its dinuclear metal binding site, and flavodiiron proteins contains a diiron site.	5.64559e-38
NC_015957.1\|WP_014059880.1\|8051693_8052683_-\|DNA-binding-protein-WhiA	gnl\|CDD\|273194	TIGR00647, DNA_bind_WhiA, DNA-binding protein WhiA. This family describes a DNA-binding protein widely conserved in Gram-positive bacteria, and occasionally occurring elsewhere, such as in Thermotoga. It is associated with cell division, and in sporulating organisms with sporulation. [Cellular processes, Cell division].	6.03511e-139
NC_015957.1\|WP_014059876.1\|8045219_8045996_-\|triose-phosphate-isomerase	gnl\|CDD\|234589	PRK00042, tpiA, triosephosphate isomerase; Provisional.	8.07803e-145
NC_015957.1\|WP_009718803.1\|8044326_8044662_-\|RNA-polymerase-binding-protein-RbpA	gnl\|CDD\|379162	pfam13397, RbpA, RNA polymerase-binding protein. RbpA is a family bacterial RNA polymerase-binding proteins. RbpA acts as a transcription factor by binding to the sigma subunit of RNA polymerase.	7.47642e-59
NC_015957.1\|WP_014059890.1\|8064552_8065863_+\|MHS-family-MFS-transporter	gnl\|CDD\|340927	cd17369, MFS_ShiA_like, Shikimate transporter and similar proteins of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.31998e-155
NC_015957.1\|WP_014059892.1\|8067181_8069170_-\|TerD-family-protein	gnl\|CDD\|132992	cd06974, TerD_like, Uncharacterized proteins involved in stress response, similar to tellurium resistance terD. Tellurium resistance terD like proteins. This family is composed of uncharacterized proteins involved in stress response, such as the tellurium resistance proteins, chemical-damaging agent resistance proteins, and general stress proteins from a variety of organisms. The tellurium resistance proteins are homologous terA,-D,-E,-F,-Z,-X gene products, which confer tellurium resistance mediated by plasmids. Currently, the biochemical mechanism of tellurium resistance remains unknown. The family also contains several ter gene homologues, YceC, YceD, YceE, for which there is no clear evidence for any involvement in the tellurium resistance. A putative cAMP-binding protin CABP1 shows a significant similarity to the terD protein and is also included in this family.	3.73127e-21
NC_015957.1\|WP_014059886.1\|8058737_8059688_+\|carbohydrate-kinase	gnl\|CDD\|238572	cd01167, bac_FRK, Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into glucose-6-phosphate. This is in contrast to FRKs [or ketohexokinases (KHKs)] from mammalia and halophilic archaebacteria, which phosphorylate fructose to fructose-1-phosphate.	1.36427e-78
NC_015957.1\|WP_014059881.1\|8052673_8053693_-\|uridine-diphosphate-N-acetylglucosamine-binding-protein-YvcK	gnl\|CDD\|211689	TIGR01826, Putative_gluconeogenesis_factor, conserved hypothetical protein, cofD-related. This model represents a subfamily of conserved hypothetical proteins that forms a sister group to the family of CofD, (TIGR01819), LPPG:Fo 2-phospho-L-lactate transferase, an enzyme of cytochrome F420 biosynthesis. Both this family and TIGR01819 are within the scope of the pfam01933. [Hypothetical proteins, Conserved].	4.31368e-97
NC_015957.1\|WP_014059875.1\|8044878_8045106_-\|preprotein-translocase-subunit-SecG	gnl\|CDD\|235881	PRK06870, secG, preprotein translocase subunit SecG; Reviewed.	2.01413e-13
NC_015957.1\|WP_014059887.1\|8059766_8062799_-\|excinuclease-ABC-subunit-UvrA	gnl\|CDD\|234734	PRK00349, uvrA, excinuclease ABC subunit UvrA.	0
NC_015957.1\|WP_014059878.1\|8047286_8048291_-\|type-I-glyceraldehyde-3-phosphate-dehydrogenase	gnl\|CDD\|223135	COG0057, GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism].	0
NC_015957.1\|WP_014059879.1\|8048466_8051433_-\|zinc-carboxypeptidase	gnl\|CDD\|349432	cd03859, M14_CPT, Peptidase M14 Carboxypeptidase T subfamily. Peptidase M14-like domain of carboxypeptidase (CP) T (CPT), CPT belongs to the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding CPs which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key determinant of specificity. CPT has moderate similarity to CPA and CPB, and exhibits dual-substrate specificity by cleaving C-terminal hydrophobic amino acid residues like CPA and C-terminal positively charged residues like CPB. CPA and CPB are M14 family peptidases but do not belong to this CPT group. The substrate specificity difference between CPT and CPA and CPB is ascribed to a few amino acid substitutions at the substrate-binding pocket while the spatial organization of the binding site remains the same as in all Zn-CPs. CPT has increased thermal stability in presence of Ca2+ ions, and two disulfide bridges which give an additional stabilization factor.	9.93333e-111
NC_015957.1\|WP_043240596.1\|8063029_8063761_+\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	gnl\|CDD\|236578	PRK09583, PRK09583, mycothiol-dependent maleylpyruvate isomerase; Reviewed.	1.26413e-71

>NC_015957.1|WP_014059883.1|8054621_8056832_-|excinuclease-ABC-subunit-UvrC
MADPSSYRPKPGQIPESPGVYKFRDEHGRVIYVGKAKSLRPRLSSYFQDLANLHPRTRTMVTTAAAVEWTVVSTEVEALQLEYSWIKEFDPRFNVKYRDDKSYPFLAVTLNEEFPRVQVMRGAKKKGVRYFGPYGHAWAIRETVDLMLRVFPVRTCSAGVFKRSAQIGRPCLLGYIGKCSAPCVGRVTAEEHRELAEEFCDFMAGRTGTYLRRLEQQMHEAAEDMEYEKAARLRDDIGALKRAMEKNAVVLADATDADLIAVAEDELEAAVQIFHVRGGRVRGQRGWVTDKVEAVDTAGLVEHALQQLYGEERGDAVPKEVLVPAVPDPAEPVTQWLTERRGSLVDLRIPQRGDKKDLMQTVQRNAQQALALHKTKRASDLTTRSRALEEIAEALGLDSAPLRVECFDISHLQGDDVVASMVVFEDGLPRKSEYRRFQIKSFAGQDDVRSMHEVVSRRFRRYLMEKQKTGEWEEQATGATEDTEATGVSGVTAPPGQAPPGQAPPGQAPPGQTPSGQAPPGQAPPGQTPSGQAPPGRALDGPSDGPSGPIDEEGRPKRFAYPPQLVVVDGGKPQVAAAQRALDELGVDDVAVCGLAKRLEEVWLPDEEDPVVLPRSSEGLYLLQRVRDEAHRFAITYQRSKRAKSMKAGPLDSVPGLGDSRKQALLKHFGSVKRLRAATVEQICEVPGVGRKTAETVAAALAGSAPAAPAVNTATGEIIEDEAAGAASSSNGGTRP
>NC_015957.1|WP_014059882.1|8053689_8054625_-|RNase-adapter-RapZ
MTEHENHGDGAQVNTGTSGEPAEAAAIPELVIISGMSGAGRSTAAKCLEDLGWFVVDNLPPALIPTMVDLGARSQGNVARIAVVVDVRGRRFFDNLRESLADLAAKSVKRRVLFLEASDEALVRRFESVRRPHPLQGDGRIVDGIAAERDLLRELRGDADLVIDTSSLNVHELRAKMDPQFAGEEEPELRATVMSFGYKYGLPVDADLVVDCRFLPNPHWVPELRPFTGLNEEVSSYVFNQPGAKEFLDRYAELLQLIAAGYRREGKRYVTIAIGCTGGKHRSVAMSERLAPRLAAEGVETVIVHRDMGRE
>NC_015957.1|WP_014059881.1|8052673_8053693_-|uridine-diphosphate-N-acetylglucosamine-binding-protein-YvcK
MTIRTKRLRRLVGARTSRSAQPKVVALGGGMGLSASLAALRRITGDLTAVVTVADDGGSSGRLRDELGVLPPGDLRKALAALCGDDDWGQTWARVIQHRFISEGELHGHAVGNVLIVALWEQLGDHVKALDLVGRLLGAHGRVLPMSAVPLELQAYVRGHDPARPDEVSTVAGQATVALTRGEVQSVHLVPHDPPAVPEAVEAVRDADWVVLGPGSWFSSVIPHLLVPDLLQALTETKARRVLSLNLAPQPGETDGFSPQRHLEVLARHAPKLAFDVVLADEAAVPDQSSLCDAAKRLGGTVELAPVAATDGAPKHDPELLAAAYDRIFRMHGRIGPWR
>NC_015957.1|WP_014059880.1|8051693_8052683_-|DNA-binding-protein-WhiA
MAMTAAVKDEISRLPVTRTCCRKAEVSAILRFAGGLHLVSGRIVIEAELDTGIAARRVRKDILEIFGHSSDLVVMAPGGLRRGSRYVVRVVAGGDQLARQTGLVDGRGRPIRGLPPQVVSGATCDAEAAWRGAFLAHGSLTEPGRSSSLEVTCPGPEAALALVGAARRLQIPAKAREVRGVDRVVVRDGDAIGALLTRLGAHESVLAWEERRMRREVRATATRLANFDDANLRRSARAAVAAGARVQRALEILADEVPEHLAAAGRLRMEHKQASLEELGALADPPLTKDAVAGRIRRLLAMADKRAQDLGIPGTESSLTEEMAEGMVG
>NC_015957.1|WP_014059879.1|8048466_8051433_-|zinc-carboxypeptidase
MKLRRTVRSSGAVVALAALLLGGLAAAPAAPAQPPANPAGDGLSVWTAQVTKGQIPLLLRAGADGTELGRQVPGKGSGPVELYLTGKQAAALRGKGVRLTEKKISAPTSNRLKAAGDGVFRPYSGQGGLQQEIVETGRAHPGLAKVVSIGKTGRGKDILALKLSKGAGKTRDGSKPSVLYMSNQHAREWITPEMTRRLMHYYLDNYGKDDRVTRIVDHTELWFVLSANPDGYDYTHQSPDNRQWRKNLRDNNGDGKITAGDGVDLNRNFGYKWGYDNEGSSADPADETYRGPAPGSEPETKALDAFEKRIGFTYGINYHSAAELLLYGVGWQVATPTPDDVLYKSLAGTPEHSAIPGYHPQVSSELYTTNGEADGHAANVNGMMMFTPEMSTCQTASGVDPNDAWQPRDCASVFTFPDDEKLIAQEFTKNIPFALSVAETAEHPDRPSSSVGLTAPDFTPETFTTSYARGGDQDVAVTVRKSVRDKRLNYRVDGGRVRTASLKAWQGGETYGGEDNVLFDQYRAAVKGADPGQQIKVWFTGRTKSGKRTVSESFTYTVAKRPRADTLVIAEEGGSSPARHTAAYTRALADNGRKAAVWDVATQGAPSALGVLSHFRTVLWYTGAERPGGPTLLAVRDFLNEGGKLITTGERAGGSSEVGPADTDDFSQYYLGADSRLTLKSPTAFQGAGALAGTGASLGDAPGNPLDAAGAYTVTSDVLPPKDFPRFRSAGAGAYPGTRTPYQPYEGDWMAAAGHRDNSWMRLSRRVDLTGVAAADKPALAFRLSYDTEPGYDHVVIEAHTAGQDDWTTLPDANGGSSTEVPTECEGGFLLNLHPFLKHYLTPGDDGCGAQGSTGAWNSLTGSSEGWRPVSVDLSGYAGKKAELAVSYVTDPGTGGRGAFVDSTEFTVGGTAKDSEGFETALGPWSTSAAPEGSPANSGDWSRSRELFHTVAGVTTRDTVLLGFGLEHVPDAAQRARLVADALRALRR
>NC_015957.1|WP_014059878.1|8047286_8048291_-|type-I-glyceraldehyde-3-phosphate-dehydrogenase
MTIRVGINGFGRIGRNYFRALLEQGADIEIVGVNDLTDNATLVHLLKYDTILGRLKHEVSHTEDTITVGNQTFKTMAERDPAALPWGELGADIVVESTGIFTKREDAAKHLAAGAKKVLISAPAKDEDITIVMGVNNEKYDPANQHVISNASCTTNCVAPMAKVLDENFGIVKGMMTTVHAYTNDQRILDFPHKDLRRARAAAENIIPTSTGAAKATALVLPQLKGKLDGIAMRVPVPTGSVTDLVLELDREVTKDEINTAFQKAAEGQLKGILEYTEDPIVSSDIVNWPASCTFDSSLTMAQGKQVKVIGWYDNEWGYSNRLVDLTVFVGERL
>NC_015957.1|WP_014059877.1|8046001_8047204_-|phosphoglycerate-kinase
MKTIDDLQVAGQRVFVRADLNVPLDGETITDDGRIRAAVPTINKLLDRGAKVIVASHLGRPKGAPDPQYSLAPVARRLGELLGKQVAFATDTVDESARATVAALGDGEVALLENLRFNAGETSKDDAERGAFADRLAALADLYVGDGFGAVHRKHASVYDLPARLPHAAGELIAAELSVLKKLTEDVKRPYAVVLGGAKVSDKLGVIDHLLEKADRILIGGGMAYTFLKAQGHEVGRSLLQEDQVPAVRDYLRRAKERGVEFVLPVDVTAAPEFPDLKTKAPANPRVIAADAIPADLQGLDIGPETRKLYASKLADAATVFWNGPMGVFEHPDFAEGTRAVAQALLDSPAFTVVGGGDSAAAVRILGFDENAFGHISTGGGASLEYLEGKTLPGLAALED
>NC_015957.1|WP_014059876.1|8045219_8045996_-|triose-phosphate-isomerase
MSDRTPLMAGNWKMNLNHLEAIAHVQKLAFALTDKDYEAVEVAVLPPFTDLRSVQTLVDGDKLKIKYGAQDISAHDSGAYTGEISGPMLAKLKCAFAVVGHSERRQYHCESDELCNAKVKAAFRHDLTPILCVGEGLEVRKAGNQVAHTLAQVDGGLKDIPAEQAETIVIAYEPVWAIGTGEVATPEDAQEVCGAIRGRLAELYGQEVADKVRIQYGGSVKSGNVAAIMAQPDVDGALIGGAALDADEFVKIVRFRDQ
>NC_015957.1|WP_014059875.1|8044878_8045106_-|preprotein-translocase-subunit-SecG
MGFSIALIIFSLLLMMLVLMHKGKGGGLSDMFGGGMQSSVGGSSVAERNLDRITVVVGLLWFVCIVVLGLLMKLD
>NC_015957.1|WP_009718803.1|8044326_8044662_-|RNA-polymerase-binding-protein-RbpA
MASGNAIRGSRVGAGPMGEAERGESAPRLRISFWCSNGHETVPSFASDAQIPDTWDCPRCGFPAGKDRDNPPDPPRTEPYKTHLAYVRERRSDADGEAILAEALAKLRGEI
>NC_015957.1|WP_014059885.1|8057670_8058741_+|LacI-family-transcriptional-regulator
MATMVDVARRAGVSVATVSHVLNETRPVRPDTRKAVLDAIDDLGYIPNTLARSLVTARTRSIGLAVSAISNPYFTEILQGVESSALEQGYGLLIADPHDDPEHERKVVRLLHERRVDGVIVAPSAEPAGLLEYLARRKIPAVFLDRLVGDAHDQVCAENSRPVEQLVHHLAGLGHTRIGLVAGLPGLSTTTERIAGYRAGLERHGLPCRPGLLAEGHSEAPGAQDAVHRLLASPEPPTAIITANNAMTIGALRALRTAGLSVPDDLALVCFDDFSWADVFSPGLTAISQPSREAGATAVRLLLDRLENPGRPPRTVRLPCAFVHRTSCGCVAEAPDRPLDHPLPGTPGLPGKDPVS
>NC_015957.1|WP_014059886.1|8058737_8059688_+|carbohydrate-kinase
MIVVAGEALIDLVPERTSSAAAGDRLPALRPARGGGPYNTALALGRLGSPTAFCSRVSTDGFGEALLEGLRKDGVDTALVQRGQEPTTLAVASIGTDGSAGYGFYVQGTADRLFALPPSLPEGVSALSLGTCSLVLEPGASAYEALLRREAARGVFTTLDPNIRTGLIPDADAYRARFQGWLPHVGLLKLSIEDARWLADSEDAEDVETAVGQWLAAGPAAVVLTHGGEGLSVRRQDGSVLSVPGERVDIVDTIGAGDTVNAALLHRLAGHQALSAPALAKLDEAAWLDVLGFAARAAAITCSRAGAEPPYASELA
>NC_015957.1|WP_014059887.1|8059766_8062799_-|excinuclease-ABC-subunit-UvrA
MADRLIVRGAREHNLKNVSLDLPRDSLIVFTGLSGSGKSSLAFDTIFAEGQRRYVESLSSYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTSRNPRSTVGTITEVYDYLRLLFARIGKPHCPECGRPIARQSPQAIVDRVLELPEGSRFQVLSPLVRERKGEFVDLFSDLQTKGYSRARVDGATVQLSDPPKLKKQEKHTIEVVIDRLTVKDSAKRRLTDSVETALGLSGGMVILDFVDLDEDDPQRERMFSEHLYCPYDDLSFEELEPRTFSFNSPFGACPDCTGIGTRMEVDPELIIPDEEKSLDEGAIHPWSHGHTKDYFGRLVGALADALGFRTDIPWAGLPQRAKKALLNGHRTQIEVRYRNRYGRQRAYTTAFEGAVPYVKRRHSEAESDASRERFEGYMREVPCPTCEGTRLKPIVLAVTVQDKSIADVSAMSISECAEFLRAMELSPREKTIAERVLKEVNERLRFLVDVGLDYLSLNRAAGTLSGGEAQRIRLATQIGSGLVGVLYVLDEPSIGLHQRDNHRLIETLVRLRDLGNTLIVVEHDEDTIKASDWVVDIGPGAGEHGGKVVHSGPLSELLVNEDSVTGHYLSGKKAIPLPSARRAVDPKRHLTVHGARENNLQDIDVSFPLGVLTAVTGVSGSGKSTLVNDILYTHLARELNGARAVPGRHTRVAGDDLVDKVVHVDQSPIGRTPRSNPATYTGVFDHVRKLFAETMEAKVRGYQPGRFSFNVKGGRCENCSGDGTIKIEMNFLPDVYVPCEVCHGARYNRETLEVHYKGKSIAEVLDMPIEEGLDFFEAVPTIARHLRTLNEVGLGYVRLGQPAPTLSGGEAQRVKLASELQKRSTGRTVYVLDEPTTGLHFEDISKLITVLSGLVDKGNTVIVIEHNLDVIKTADWVVDMGPEGGSGGGLVIAEGTPEEVASVPASHTGKFLRDMLGDWVSDATVPAARNGGAAATKGPATKAPAKKAAAKSTAAKKTAAKKTVAKKAAAKSTVASKRTAAK
>NC_015957.1|WP_043240596.1|8063029_8063761_+|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme
MTDYVRDALAVQEATDRLLTAVAALDDASLASPSELPGWTRGHVLAHLARNADGLVNLLTWARTGQETPMYADAQTRDAEIRRDAARPLAVHLDDLRTSATRFDTAATALPPERLPYEVTLRGGVRERAAGLPLRRLGEVELHHVDLGIGYTVTDLPATFVESQLTLLIRTRFAGRPDIPPLRLATGPGEEDVRHTGRPAAPGESPVTVTGSPAALLGWLTGRTDGSGLSCPDGPLPVLPALG
>NC_015957.1|WP_014059889.1|8063765_8064422_+|MBL-fold-metallo-hydrolase
MTYSGVVTVGGPADVHELPDLMISKVAVGPMNNNAYLLRCRATDEQLLIDAAAEPHTLLSLIGESGIASVVTTHRHQDHWSALREVVDATGARTYAGQYDAEGIPVPTDVPVADGDTVRVGRVELTARHLVGHTPGSIALVYNDPHGHPHVFTGDCLFPGGVGNTWKDSKAFESLINDVETKLFDRLPDETWVYPGHGDDTTLGAERPHLEEWRERGW
>NC_015957.1|WP_014059890.1|8064552_8065863_+|MHS-family-MFS-transporter
MARLAAASLAGTAIEFYDFFVYGTAAALVLGPLFFPTFSPLAGTLAAFGTFAVGFVSRPLGSMLFGPIGDRHGRRPVLIASLLLTGVATVAVGFVPTYDSVGIAAPVLLLVLRFLQGLGLGGEWGGAVLLTAEHAPAERRGLWSGFPQVGPAIGFLLANGTMLTLSATLSDAEFRSWGWRVPFWGAGLLAGAGLLLRAQLTESPRFQELTEQGDRAAAPLAEVVRGHWRLVLLTAGGLAVGYAVFYAVTTWSLAYGTERLGVARTTLLGCIMAAVAVMGALTPLAAHLGDRFGRRPLCLVGCVATVAWMFPLVALLRTGEPPLMFLGILGALLAFISMFAVTSAYLPELFEARVRCTGAGLGYNLAGVLGGALTPIVATAMSHGDGPPWGVAVYLTAAALLSLGCFVLLPETRPTADRPDGGRSAVRPLEAGEAAV
>NC_015957.1|WP_014059891.1|8065953_8066958_-|TerC-family-protein
MDVSVTMWGLTIVGLCALIAADFFIGGRKPHEVSIKEAGIWTAVWVALAALFGLGLLVFAGGRPSGEFFAGFITEKSLSVDNLFVFVLIMAKFSVPTIYQQRVLMVGVLIALVLRAVFIAAGAAIISTFSWVFFIFGAFLIWTAWKLVQEARADEETEEFEENRLLKAVEKRFPSTDQYHGTKLFIMENGKRLMTPMLIVMLAIGTTDVLFALDSIPAIFGLTQDPYIVFTANAFALMGLRQLYFLIGGLLKKLVHLSYGLSIILGFIGVKLVLHALHEAGVHVPEISIPVSLGVICAVLAVTTVTSLYASKKQALAEAGSGEGRARDKDSVDV
>NC_015957.1|WP_014059892.1|8067181_8069170_-|TerD-family-protein
MTAELVRGQNHPLPQTRLEIRISAGNPIVAGATLGDERGTVHGAEWVAHPASPQLAGIEVPKQAAADHRLAVDLDAMPGHIHRVTVLLALPAGVGGPARFGVMAAPFVAVTGLDGTEIAGYTITDLDSESAVTALELYRRQGAWKVRAVGQGYAGGLAAMLNDQGLAEAADLAARINEAVARGMARSVAQPRPRSEGDGRVRTAAGGGADPVPASGGADPAPASADPAPDQPQPPTQQPQGTPAPGVPVNYEHPGRRTAAPPTPAPTAPPAAPGQPAQPVAGDASGWTMDERLYNQVWGMFEDLARTAAAYRSAVDFAESRMEQELDRVLSDPRTRVGPAADSARAAARAKHTDLVEQARAALDRDLAQLTAEAEVVEPALPPAYARWDSPVWQAYQVPMEVPMALRVGDLHLPERTGLRIPMLVRLPLERGLWIDAGRSGGFDEGPADSGELRRLAADAAVAIAARLLAVYPAGEIAVHVIDPAGSAAGSFAPLVGSGALAEPPAAGAQGVSSVLAALTRRVDLVQMAVRSGATDALPPDLDTAEQLLIVHDFPHGFDDRAVTQLRYLADEGPAVGVHLMMVADREDARAYGPVLDPLWRSLLRLTPVADDHLADPWVGHAWTYEPSMVPRGSRVLDQVLGEASRAAKALKAARARPSYGN
>NC_015957.1|WP_014059893.1|8069342_8069921_-|TerD-family-protein
MTVNMSKGQAISLQKADGGALTAVRMGLGWQAAPRRGLFGSRTREIDLDASAVLFADKQPTDVVFFRHLVSDDGSVRHTGDNLVGGAGQGGDDEAILVDLQRVPVHIDQIVFTVNSFTGQTFAEVQNAFCRLVDETNGQELARYTLTGGGQYTAQIMATVQRAGGAWQMKAVGEPANGRTFQDLMPHIVPHL
>NC_015957.1|WP_014059894.1|8070115_8072254_-|excinuclease-ABC-subunit-UvrB
MRPVTQLERKVAPFEVVSSYQPSGDQPTAIADLERRVRGGEKDVVLLGATGTGKSATTAWMIEKLQRPTLVMAPNKTLAAQLANEFRELLPNNAVEYFVSYYDYYQPEAYVPQSDTYIEKDSSINEEVERLRHSATNSLLTRRDVIVVASVSCIYGLGTPQEYVDRMVRLKVGEEIDRDQLLRRFVDIQYARNDMAFTRGTFRVRGDTIEIFPVYEELAVRIEMFGDEIEALSTLHPLTGEVISEDRELYVFPASHYVAGPERMEKAIAGIEAELTETLARLEKQGKLLEAQRLRMRTTYDIEMMRQIGTCSGIENYSLHIDGRETGSPPHTLLDYFPEDFLLVIDESHVTVPQIGAMYEGDASRKRTLIEHGFRLPSALDNRPLKWEEFLKRVGQTVYLSATPGPFELSRGDGFVEQIIRPTGLIDPEVVVKPTEGQIDDLIHEIRTRTEKDERVLVTTLTKKMAEDLTDYMLELGIQVRYLHSDVDTLRRVELLRELRAGEFDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSGTSLIQTIGRAARNVSGQVHMYADKVTAAMAKAIDETNRRRDKQIAYNKANKIDPQPLRKKINDIVAQIAREDVDTEQLLGTGYRKVKDGKDAKTPVPAAGGKAAKGGKAAKGKAKEEVLTDRPAAELAEQIEEMTDRMRAAAAELQFEVAARLRDEVSELKKELRQMREAGVS

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Crispr_ID: NC_015957_18

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015957_18

8571544-8571612

Orphan

Consensus_repeat	Method
CGGCGGGCGGGGCCGGGTGGTCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015957_18

>merge|NC_015957|18|8571544-8571612|CRISPRCasFinder
CGGCGGGGGCGGTCCGGTGCGGCCCCGTGGCGGGGTTGTCGGCAGGGGCGGGGGCGGTGGGGTCGTCGG

>NC_015957|18|17|8571544-8571612|CRISPRCasFinder
CGGCGGGGGCGGTCCGGTGCGGC	CCCGTGGCGGGGTTGTCGGCAG
GGGCGGGGGCGGTGGGGTCGTCGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_015957.1\|WP_014060346.1\|8579692_8580151_-\|peroxiredoxin	unknown	unknown	gnl\|CDD\|239316
NC_015957.1\|WP_014060332.1\|8562613_8563576_+\|ATP-grasp-ribosomal-peptide-maturase	unknown	unknown	gnl\|CDD\|275040
NC_015957.1\|WP_014060335.1\|8566550_8566787_+\|zinc-ribbon-domain-containing-protein	unknown	unknown	gnl\|CDD\|274226
NC_015957.1\|WP_043237024.1\|8565087_8566485_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274008
NC_015957.1\|WP_043237023.1\|8561232_8561826_+\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014060330.1\|8561998_8562142_+\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014060338.1\|8568863_8569724_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|319822
NC_015957.1\|WP_050993826.1\|8562324_8562588_+\|putative-ATP-grasp-modified-RiPP	unknown	unknown	gnl\|CDD\|275039
NC_015957.1\|WP_014060327.1\|8559883_8561134_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NC_015957.1\|WP_014060350.1\|8585440_8585875_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377188
NC_015957.1\|WP_014060337.1\|8568045_8568708_-\|SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|366722
NC_015957.1\|WP_014060345.1\|8579016_8579592_-\|TerD-family-protein	unknown	unknown	gnl\|CDD\|376767
NC_015957.1\|WP_014060341.1\|8574733_8575945_+\|stress-protein	unknown	unknown	gnl\|CDD\|376767
NC_015957.1\|WP_014060348.1\|8581193_8583923_+\|pyruvate-dehydrogenase-(acetyl-transferring),-homodimeric-type	unknown	unknown	gnl\|CDD\|236500
NC_015957.1\|WP_014060347.1\|8580280_8580721_-\|DUF3052-domain-containing-protein	unknown	unknown	gnl\|CDD\|378615
NC_015957.1\|WP_014060343.1\|8577012_8578206_-\|DUF475-domain-containing-protein	unknown	unknown	gnl\|CDD\|237583
NC_015957.1\|WP_014060344.1\|8578258_8578834_-\|TerD-family-protein	unknown	unknown	gnl\|CDD\|376767
NC_015957.1\|WP_014060340.1\|8573308_8574499_-\|HpcH/HpaI-aldolase/citrate-lyase-family-protein	unknown	unknown	gnl\|CDD\|379744
NC_015957.1\|WP_014060333.1\|8563572_8564709_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|275041
NC_015957.1\|WP_014060342.1\|8576035_8576764_-\|Tellurium-resistance	unknown	unknown	gnl\|CDD\|226595

Protein	Function_ID	Function_description	E-value
NC_015957.1\|WP_014060332.1\|8562613_8563576_+\|ATP-grasp-ribosomal-peptide-maturase	gnl\|CDD\|275040	TIGR04187, conserved_hypothetical_protein, ATP-grasp ribosomal peptide maturase, SAV_5884 family. Members of this protein family are ATP-grasp ligase family enzymes that regularly occur in a contexts with a methyltransferase and a putative ribosomally translated post-translationally modified peptide precursor. Because of this conserved gene neighborhood and close sequence similarity to ATP-grasp enzymes from microviridin/marinostatin biosynthesis cassettes, this enzyme is suggested also to serve as a peptide maturase.	9.64277e-129
NC_015957.1\|WP_014060346.1\|8579692_8580151_-\|peroxiredoxin	gnl\|CDD\|239316	cd03018, PRX_AhpE_like, Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater similarity to 2-cys PRXs than 1-cys PRXs. PRXs are thiol-specific antioxidant (TSA) proteins that confer a protective role in cells through their peroxidase activity in which hydrogen peroxide, peroxynitrate, and organic hydroperoxides are reduced and detoxified using reducing equivalents derived from either thioredoxin, glutathione, trypanothione and AhpF. The first step of catalysis is the nucleophilic attack by the peroxidatic cysteine on the peroxide leading to the formation of a cysteine sulfenic acid intermediate. The absence of a resolving cysteine suggests that functional AhpE is regenerated by an external reductant. The solution behavior and crystal structure of AhpE show that it forms dimers and octamers.	7.91738e-79
NC_015957.1\|WP_043237024.1\|8565087_8566485_+\|hypothetical-protein	gnl\|CDD\|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	1.38516e-05
NC_015957.1\|WP_014060327.1\|8559883_8561134_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	9.3877e-08
NC_015957.1\|WP_014060338.1\|8568863_8569724_-\|hypothetical-protein	gnl\|CDD\|319822	cd07520, HAD_like, uncharacterized family of the haloacid dehalogenase-like (HAD) hydrolase superfamily. The haloacid dehalogenase-like (HAD) hydrolases are a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members include 2-L-haloalkanoic acid dehalogenase (C-Cl bond hydrolysis), azetidine hydrolase (C-N bond hydrolysis); phosphonoacetaldehyde hydrolase (C-P bond hydrolysis), phosphoserine phosphatase and phosphomannomutase (CO-P bond hydrolysis), P-type ATPases (PO-P bond hydrolysis) and many others. Members are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	4.86161e-11
NC_015957.1\|WP_050993826.1\|8562324_8562588_+\|putative-ATP-grasp-modified-RiPP	gnl\|CDD\|275039	TIGR04186, conserved_hypothetical_protein, putative ATP-grasp target RiPP. A RiPP is a ribosomally produced, post-translationally modified peptide. This family regularly occurs next to ATP-grasp enzymes related to those of microviridin maturation and next to a methyltransferase.	1.4081e-09
NC_015957.1\|WP_014060335.1\|8566550_8566787_+\|zinc-ribbon-domain-containing-protein	gnl\|CDD\|274226	TIGR02605, CxxC_CxxC_SSSS, putative regulatory protein, FmdB family. This model represents a region of about 50 amino acids found in a number of small proteins in a wide range of bacteria. The region begins usually with the initiator Met and contains two CxxC motifs separated by 17 amino acids. One member of this family is has been noted as a putative regulatory protein, designated FmdB (SP:Q50229, ). Most members of this family have a C-terminal region containing highly degenerate sequence, such as SSTSESTKSSGSSGSSGSSESKASGSTEKSTSSTTAAAAV in Mycobacterium tuberculosis and VAVGGSAPAPSPAPRAGGGGGGCCGGGCCG in Streptomyces avermitilis. These low complexity regions, which are not included in the model, resemble low-complexity C-terminal regions of some heterocycle-containing bacteriocin precursors. [Regulatory functions, DNA interactions].	1.62701e-11
NC_015957.1\|WP_014060350.1\|8585440_8585875_-\|hypothetical-protein	gnl\|CDD\|377188	pfam03995, Inhibitor_I36, Peptidase inhibitor family I36. This domain is currently only found in a small set of S. coelicolor secreted proteins. There are four conserved cysteines that probably form two disulphide bonds. Proteins 2SCK31.15C and SCO3675 also have probable beta-propellers at their C-termini. This family includes Streptomyces nigrescens SmpI, a known peptidase inhibitor of known structure. This protein has a crystallin like fold pfam00030 and is distantly related by sequence. It is not known whether other members of this family are peptidase inhibitors.	0.000397136
NC_015957.1\|WP_014060337.1\|8568045_8568708_-\|SAM-dependent-methyltransferase	gnl\|CDD\|366722	pfam01596, Methyltransf_3, O-methyltransferase. Members of this family are O-methyltransferases. The family includes catechol o-methyltransferase, caffeoyl-CoA O-methyltransferase and a family of bacterial O-methyltransferases that may be involved in antibiotic production.	8.33706e-59
NC_015957.1\|WP_014060345.1\|8579016_8579592_-\|TerD-family-protein	gnl\|CDD\|376767	pfam02342, TerD, TerD domain. The TerD domain is found in TerD family proteins that include the paralogous TerD, TerA, TerE, TerF and TerZ proteins It is found in a stress response operon with TerB and TerC. TerD has a maximum of two calcium-binding sites depending on the conservation of aspartates. It has various fusions to nuclease domains, RNA binding domains, ubiquitin related domains, and metal binding domains. The ter gene products lie at the centre of membrane-linked metal recognition complexes with regulatory ramifications encompassing phosphorylation-dependent signal transduction, RNA-dependent regulation, biosynthesis of nucleoside-like metabolites and DNA processing linked to novel pathways.	1.51358e-119
NC_015957.1\|WP_014060341.1\|8574733_8575945_+\|stress-protein	gnl\|CDD\|376767	pfam02342, TerD, TerD domain. The TerD domain is found in TerD family proteins that include the paralogous TerD, TerA, TerE, TerF and TerZ proteins It is found in a stress response operon with TerB and TerC. TerD has a maximum of two calcium-binding sites depending on the conservation of aspartates. It has various fusions to nuclease domains, RNA binding domains, ubiquitin related domains, and metal binding domains. The ter gene products lie at the centre of membrane-linked metal recognition complexes with regulatory ramifications encompassing phosphorylation-dependent signal transduction, RNA-dependent regulation, biosynthesis of nucleoside-like metabolites and DNA processing linked to novel pathways.	4.3319e-63
NC_015957.1\|WP_014060348.1\|8581193_8583923_+\|pyruvate-dehydrogenase-(acetyl-transferring),-homodimeric-type	gnl\|CDD\|236500	PRK09405, aceE, pyruvate dehydrogenase subunit E1; Reviewed.	0
NC_015957.1\|WP_014060347.1\|8580280_8580721_-\|DUF3052-domain-containing-protein	gnl\|CDD\|378615	pfam11253, DUF3052, Protein of unknown function (DUF3052). This family of proteins with unknown function appears to be restricted to Actinobacteria.	5.03269e-68
NC_015957.1\|WP_014060343.1\|8577012_8578206_-\|DUF475-domain-containing-protein	gnl\|CDD\|237583	PRK14013, PRK14013, hypothetical protein; Provisional.	4.34444e-169
NC_015957.1\|WP_014060344.1\|8578258_8578834_-\|TerD-family-protein	gnl\|CDD\|376767	pfam02342, TerD, TerD domain. The TerD domain is found in TerD family proteins that include the paralogous TerD, TerA, TerE, TerF and TerZ proteins It is found in a stress response operon with TerB and TerC. TerD has a maximum of two calcium-binding sites depending on the conservation of aspartates. It has various fusions to nuclease domains, RNA binding domains, ubiquitin related domains, and metal binding domains. The ter gene products lie at the centre of membrane-linked metal recognition complexes with regulatory ramifications encompassing phosphorylation-dependent signal transduction, RNA-dependent regulation, biosynthesis of nucleoside-like metabolites and DNA processing linked to novel pathways.	8.18834e-119
NC_015957.1\|WP_014060340.1\|8573308_8574499_-\|HpcH/HpaI-aldolase/citrate-lyase-family-protein	gnl\|CDD\|379744	pfam15617, C-C_Bond_Lyase, C-C_Bond_Lyase of the TIM-Barrel fold. This family of TIM-Barrel fold C-C bond lyase is related to citrate-lyase. These genes are found in the biosynthetic operon, with other enzymatic domains, associated with the Ter stress response operon and are predicted to be involved in the biosynthesis of a ribo-nucleoside involved in stress response.	1.25368e-170
NC_015957.1\|WP_014060333.1\|8563572_8564709_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|275041	TIGR04188, conserved_hypothetical_protein, methyltransferase, ATP-grasp peptide maturase system. Members of this protein family are predicted SAM-dependent methyltransferases that regularly occur in the context of a putative peptide modification ATP-grasp enzyme (TIGR04187, related to enzymes of microviridin maturation) and a putative ribosomal peptide modification target (TIGR04186).	4.64757e-99
NC_015957.1\|WP_014060342.1\|8576035_8576764_-\|Tellurium-resistance	gnl\|CDD\|226595	COG4110, COG4110, Uncharacterized protein involved in stress response [General function prediction only].	8.1523e-51

>NC_015957.1|WP_014060338.1|8568863_8569724_-|hypothetical-protein
MSVLVASDLDRTLIYSAAALGLDMPDAEAPRLLCVETYEGRPLSYMTETAAGLLAELVRTSVFVPTTTRTVEQYRRIRLPGPASRFAICANGGQLLVNGEPDADWHQRVRTALGDQCAPLEEVRAHLSATADPAWLLKERVAEELFAYLVVERELLPQGYVKELTQWAEPRGWTVSLQGRKIYAVPKPLTKSAAVAEIRNRTGADEVLAAGDSLLDTDLLLAADRAWRPGHGELADAGWTAPRVTVVEETGVAAGEAIVRALGERSSVTWARARSQVIRAVSRGRD
>NC_015957.1|WP_014060337.1|8568045_8568708_-|SAM-dependent-methyltransferase
MAESKSTPITAELYDYVLRHNPPLDPVLRELVEVTHRSLPQQAGMQSAEEQAPLLAFLVRLTGARHIVEVGTFTGFSALAMAQALPADGRLIACDVSEEWTAYGRKAWAKAGVEARIDLRIAPALDTLRAMPAEPHIDLAYLDADKPNYIPYWEELVPRMNPGGLIVADNVFYHGAVTAPEPSTAGAAIQAFNDHVAADVRMEAVMLTVADGLTLARRLG
>NC_015957.1|WP_014060335.1|8566550_8566787_+|zinc-ribbon-domain-containing-protein
MPRYEYRCRACGTTFELNRPMAESSAPASCPDGHDDTVKLLSTVAVTGASSSSARPPSGGGGGGGGGGGGCCGGGCCG
>NC_015957.1|WP_043237024.1|8565087_8566485_+|hypothetical-protein
MAATSAESARPSRESARPGARGRRSGRPSVLGLMLLPVPLLAVVGALSFAGGSGGRRWFGGRGESQRAEAQAAKDAAAAAFYELDTAQRDLRISIETITAVDDSPAARRTAADFSALGQRIDQVSRDYITAVDAHDLDRDDLDSATASRARTDLTRAKDALERTKADLDRFAQGLGPLLEQAETRLARLAPAVERARQALLAASNALDAVRASGLRADDLAARLAALSPELTKLNQGAGQHGVQETLRRADDVLRGAEAVRGEAERLPERSAEIDKRLVSLRTRAQAITTRAAGVEPVLSELRRRYSAACWQDLQTVPAQAARDVAQAEEKLKEAQAAREEQRWPDATALLATVRALLNSTDEAVSAAGDRLRRLDEVSFDQQKEIERTRFAIRDAQRLAMAGRSTPDPRHARPLDDAVERLERAIAGLEGRHPDWWHFLSETEAVRQTAARVVQGIREERGGGH
>NC_015957.1|WP_014060333.1|8563572_8564709_+|methyltransferase-domain-containing-protein
MITEVPTADELRRHMTEQLESTGSIRSAVWRAAFLNVPRHTFVPDFTLRSQGRLHEYSQGDPAWLAAAYSDVSLLTQFDQDGTATSSSTQPSLMAQMLESLGVRDGDTVLEIGAGTGYNAALLSHRLGPDHVVTVDVDPELVAAAAARLRQAGYEPTLVAGDGTAGHPERAPYDRLLATCGVGRIPDAWRQQVHAGGVVVANIGFGIARLAIAADHSAGGKFLPGLATFMTARPTPDATGTTAKRLVQPMLTWSGQTREITAPVVLDAPGAQFLASLLHPQVNDFALVDDEGRQIRCLFDPVTSSWARITMTGVMAARLDHGGPRDLWAEREPLLTQWRDAGRPGHQRYGLTVSSEGVHTLWLDEPDGVGWRLPDWRP
>NC_015957.1|WP_014060332.1|8562613_8563576_+|ATP-grasp-ribosomal-peptide-maturase
MTVLVLTRPQDATADLVIAELNERSVPVCRLDPGDFPEALTMAARIGPGRTPWEGVLHGQHRDVSLGDIRSVYYRRPAAFRLHPDMSEQDARWAQAEAQAGFGGLLYSLPCLWVNHPHRNALAAWPPVALATAARGGLSVPLSLITNDPGEAREFVSALPGQVAAYKAIGTTHPSDHDDRPQALWTTQVRPGEIGESVRRTAHQFQEWVDKAYEVRLTAIAHSLFAAEIHAGSDASRLDFRADYDSLTYKPCQVPEHIAQGVHALTFTFGLRYVALDFLVNPQGRWYLIDVNPNGQWGFIPDLRAPITRALADLLERANP
>NC_015957.1|WP_050993826.1|8562324_8562588_+|putative-ATP-grasp-modified-RiPP
MENAVTLTMERTQTHPAVRPFGLSKAVPVADEKLTLPALHLCPERQMSVTAAGVPFIHEPSMKSQITTTTQTREDSQLATDTENDTD
>NC_015957.1|WP_014060330.1|8561998_8562142_+|hypothetical-protein
MRHRRQDPAVRAALLAYRAVRLGLLLSVIPALLVLAIYLCIAGDPYR
>NC_015957.1|WP_043237023.1|8561232_8561826_+|hypothetical-protein
MNPQVLPWTPPNNEDVEALPAGKWWDAVRAQPTVGERAVQLLGDETGAVIQDKHGPLYWLVQVGSATSCHLRQVRVLTKLTDECTYLGVPPVSWTEGPSTHWRVPLSADHYLTDAFKLWGALAEADRAALGPVPQGRQTCYRCELPTDEPVIVDVQHGGSGAGRTVYACPPHARAYQRDVVAEAAAMRRALNRGRAR
>NC_015957.1|WP_014060327.1|8559883_8561134_+|helix-turn-helix-transcriptional-regulator
MSSDAPPDPLDHPLVFGQRMQVLRTRRGMSRTVLAGLLGKSPSWVKQIENGVLHTPGLPMILRIAEVLRVRDLAELTGDQTMPIDLFIGPGHAKLPAVRAAIDAFPLATDREAPSAAHLSARLESAWAARHSSPNHREVIGGLLPDLIRDAQLAVRQADRAPERRVAQAVLAEVYSLSQFFIAYQPDSALLWRVAERGMVAAQESEDPHAIGMAAWLTAQAHRDSGHAHFDAADAVTLETLRYLTPLLPDGPEDVCAIAGALQFEAGYTAARRGDTGTAWGFWDTARKMAEKLPADYYHPMTSFSRAIMGAHAVTVAVELHAGGESVRQAANADARTIRSRPRRARHRIEEARGYQLDGQSETALATLDKAYEAAPETIRYNGYARRIILEETESKSPTHRRRAAELAVKIGVLTA
>NC_015957.1|WP_014060340.1|8573308_8574499_-|HpcH/HpaI-aldolase/citrate-lyase-family-protein
MRHFGHLTDEVRANVFHQEPGEFSVDSPARTLAVALGATLYCPATRPKLAEDIVKQAGRGVVSMVLCLEDSIDDAEVPGAEENLIRQFAELSGLGPGTTPLPLLFIRVRTPEQIVDLLNRFGSGVRLLSGFVLPKFTEERGGAFLEALMSAENAQVTEALGGRRLFAMPVLESPELMHRETRTDTLSGISRIVDKYRERVLALRLGVTDLCSAYGLRRAPDMTAYDVQLIASVIADVVNMLGRADGTGFTITGPVWEYFKPHERMFKPQLRISPFSSGRAEALRTALIEHHMDGLLREIELDRANGLQGKTCIHPTHVAPVHALSVVSHEEFSDAVDILEPQRCGGGVVRSSYTNKMNEVKPHRAWAERTLRRAEVFGVAREDVSFVELLAASLRT
>NC_015957.1|WP_014060341.1|8574733_8575945_+|stress-protein
MTQAMLKGSNIPLEATAIRAVLRWTPGTDVPDVDASALLLDADDRVRSDEDFVFYNQPNHPSGLVRHLPKKPNQGTLTDTIEAEFSGLEPGVRRVVLAASADGGTFGQVRDLSLLLYDASSGAPREADAEPLAIFAVLPETGKEAALICGELYRRGDTWKFRALGQGYETGLVGLATQYGISVEDGEAAGGSDGDGAAAPAGREGGTAPEPPVAPAPAPEPLTVDAPEPLAAAPEPLTAPEPPATATPAAPPSAATHAPPAAPGTPPPSSSDAPTRPHSPSPAYGYPHAASPDPWDPHRTQPMQPPTAHGDSGFGYVPPQAPPPPPQAPAAGYPQPPGQAPAQPGYGYPPQQQTYGYPQSPAYGYPQQVQPTGPVAPPPLPIPVQVPDPQFVLPPQGPQFQNR
>NC_015957.1|WP_014060342.1|8576035_8576764_-|Tellurium-resistance
MAFWSNWGRSAWREFESGDASGVVELTKRQSTISLTKQGAASGNLRINLSWQMRTSDFNSRAARGSLRHPLRMFKPEPVQAQGPAMVNVDLDLAVMYELKSGSKGVVQPLGEFFGNLNEAPYVKLSGDDRFGSGSGETVYVNMDHKDDIKRLLVFVYIYDGTPAFDRTHGLVTLYPSNGPRVEIALDERAPQARSCAVVLIENVKGEMMVRREVKYVYGFQAELDRLYGWGLQWGRGYKSKV
>NC_015957.1|WP_014060343.1|8577012_8578206_-|DUF475-domain-containing-protein
MLLKTFGWSFAITVIGLALAGVLWGWKGLAIVGILSILEISLSFDNAVINAGILRKMNAFWQKIFLTVGVLIAVFGMRLVFPVIIVAITAKLSPLQAVDLAINNKDKYEHLVTAAHPAIAAFGGMFLLMIFLDFIFEERDIRWLGWLEKPLAKLGRLDTFSVVVALVVLLISATTVATDVAHGGGDKSSTVLLAGVAGLVTYLIVGGISSYFEDKLEEEEEDDEDEEAAKGADESGEETKSAANAQLNGSGGRGSSGATVVGLAGKAAFFLFLYLEVIDASFSFDGVIGAFAITNDIFEMALGLGIGAMYIRSLTVFLVRRGTLDDYVYLEHGAHYAIGALAGILLVTIKYEINEVITGLVGVVLIGASYWSSVVRNRRVAAEGEGSETKTEVTSGV
>NC_015957.1|WP_014060344.1|8578258_8578834_-|TerD-family-protein
MGVTLAKGGNVSLSKAAPNLTHVLIGLGWDARSTTGAPFDLDASALLCQSGRVLGDEYFIFYNNLKSPEGSVEHTGDNLTGEGEGDDESLLIDLVKVPAEVDKIAFPVSIHDADTRRQTFGQVSNAFIRVVNQADGQELARYDLSEDASGETAMIFGEVYRYGGEWKFRAVGQGYASGLRGIALDFGVNVS
>NC_015957.1|WP_014060345.1|8579016_8579592_-|TerD-family-protein
MGVSLSKGGNVSLTKEAPNLTAVVVGLGWDARTTTGTDFDLDASALLTNTEGKVGNDQNFVFFNNLKSPDGSVEHTGDNITGEGEGDDEQIKVNLAGVPADVAKIVFPVSIYDAETRQQSFGQVRNAFIRVVNQADGQELARYDLSEDASTETAMVFGELYRNGAEWKFRAIGQGYASGLRGIAQDFGVNV
>NC_015957.1|WP_014060346.1|8579692_8580151_-|peroxiredoxin
MSIEVGTKAPDFQLKNQHGESVKLSDFRGEKNVVLLFYPFAFTGVCTGELCALRDELPTFVNDEVQLLAVSNDSPFSLRVFAEQEGLEYPLLSDFWPHGETSRAYGVFDEDKGCAVRGTFVIDKEGVVRWTIVNGLPDARDLNDYVKALETL
>NC_015957.1|WP_014060347.1|8580280_8580721_-|DUF3052-domain-containing-protein
MSATADHAEERTNPAARLGFQPEQVVQEIGYDDDVDQELRESIEEITGQELVDEEYDDVADAVVLWFREDDGDLTDALVDAIQMIDDGAPVWLLTPKTGRDGYVEPSDINEAATTAGLSQTKSFNAGKDWTGSRLVTPKAARSGKR
>NC_015957.1|WP_014060348.1|8581193_8583923_+|pyruvate-dehydrogenase-(acetyl-transferring),-homodimeric-type
MASGSDRNPIIIGGLPSQVPDFDPEETQEWLDSLDAAVDERGRERARYLMLRLIERAREKRVAVPEMRSTDYVNTIATKSEPFFPGNEEIERKVLNATRWNAAVMVSRAQRPGIGVGGHIATFASSASLYDVGFNHFFRGKDHDSGDQIFFQGHASPGIYARAFLLDRLSEDHLDGFRQEKSKLGHALSSYPHPRSMPDFWEFPTVSMGLGPLGAIFQARMNRYMEARGVADTSNSHVWAFLGDGEMDEPESLGQLSLAAREGLDNLTFVVNCNLQRLDGPVRGNGKIIQELESQFRGAGWNVIKLVWDRTWDPLLAQDRDGILVNKLNTTPDGQFQTYATETGGYIRDHFFGEDQRLRKMVEGMTDDQILHLGRGGHDHKKIYAAYAAAKAHKGQPTVILAQTVKGWTLGPNFEGRNATHQMKKLTVDDLKRFRDRLHLPIPDQELESGLPPYYHPGRDSEEIQYMHDRRKALGGYAPTRVVRAKPLQLPGDKTYATLKKGTGQQSIATTMAFVRLLKDLMRDKEIGKRFVPIAPDEYRTFGMDSLFPSAKIYSPLGQTYESVDRELLLAYKESPTGQMLHDGISEAGCTASLIAAGSAYATHGEPLIPVYVFYSMFGFQRTGDQFWQMADQLARGFVLGATAGRTTLTGEGLQHADGHSQLLASTNPAVVAYDPAYGFEIAHIVQDGLRRMYGENSEDVFYYLTVYNEPIQHPAEPENVDREGILKGLYRYRQSEEGAIPAQILASGVAVPWAIEAQRILAEDWNVKADVWSATSWNELRRDAVEAEEHNLLHPEEEQRVPYVTRKLADAEGPKVAVSDWMRAVPDQIARWVPGTYQSLGADGFGFADTRGAARRFFHIDAESIVLGVLTELARDGKIDRSALKQAIDRYQLLDVAAADPGPAGGDA
>NC_015957.1|WP_014060350.1|8585440_8585875_-|hypothetical-protein
MRKIIKAAVSAVALTATLAATLAPAATATAATATATATGTSATGRAAAAPPRLGNCAAGQLCLWRSGGFTGARQTHELAGVDIESCVPLPSGTTAASLANRTGRPVTAYQSGECAETAEFRTYPTGSWAPETPYQVRAFKIWER

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Crispr_ID: NC_015957_19

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015957_19

8571682-8571764

Orphan

Consensus_repeat	Method
CGGCGGGCGGGGCCGGGTGGTCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015957_19

>merge|NC_015957|19|8571682-8571764|CRISPRCasFinder
CGGCGGGCGGGGCCGGGTGGTCCGGTGCGGCATGTCCCCCGGGAGCCGCCGGGGTGCCGTCGGCGGGCGGGGTCGGGTGGTCC

>NC_015957|19|18|8571682-8571764|CRISPRCasFinder
CGGCGGGCGGGGCCGGGTGGTCC	GGTGCGGCATGTCCCCCGGGAGCCGCCGGGGTGCCGT
CGGCGGGCGGGGTCGGGTGGTCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015957.1\|WP_014060346.1\|8579692_8580151_-\|peroxiredoxin	unknown	unknown	gnl\|CDD\|239316
NC_015957.1\|WP_014060332.1\|8562613_8563576_+\|ATP-grasp-ribosomal-peptide-maturase	unknown	unknown	gnl\|CDD\|275040
NC_015957.1\|WP_014060335.1\|8566550_8566787_+\|zinc-ribbon-domain-containing-protein	unknown	unknown	gnl\|CDD\|274226
NC_015957.1\|WP_043237024.1\|8565087_8566485_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274008
NC_015957.1\|WP_043237023.1\|8561232_8561826_+\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014060330.1\|8561998_8562142_+\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014060338.1\|8568863_8569724_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|319822
NC_015957.1\|WP_050993826.1\|8562324_8562588_+\|putative-ATP-grasp-modified-RiPP	unknown	unknown	gnl\|CDD\|275039
NC_015957.1\|WP_014060327.1\|8559883_8561134_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NC_015957.1\|WP_014060350.1\|8585440_8585875_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377188
NC_015957.1\|WP_014060337.1\|8568045_8568708_-\|SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|366722
NC_015957.1\|WP_014060345.1\|8579016_8579592_-\|TerD-family-protein	unknown	unknown	gnl\|CDD\|376767
NC_015957.1\|WP_014060341.1\|8574733_8575945_+\|stress-protein	unknown	unknown	gnl\|CDD\|376767
NC_015957.1\|WP_014060348.1\|8581193_8583923_+\|pyruvate-dehydrogenase-(acetyl-transferring),-homodimeric-type	unknown	unknown	gnl\|CDD\|236500
NC_015957.1\|WP_014060347.1\|8580280_8580721_-\|DUF3052-domain-containing-protein	unknown	unknown	gnl\|CDD\|378615
NC_015957.1\|WP_014060343.1\|8577012_8578206_-\|DUF475-domain-containing-protein	unknown	unknown	gnl\|CDD\|237583
NC_015957.1\|WP_014060344.1\|8578258_8578834_-\|TerD-family-protein	unknown	unknown	gnl\|CDD\|376767
NC_015957.1\|WP_014060340.1\|8573308_8574499_-\|HpcH/HpaI-aldolase/citrate-lyase-family-protein	unknown	unknown	gnl\|CDD\|379744
NC_015957.1\|WP_014060333.1\|8563572_8564709_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|275041
NC_015957.1\|WP_014060342.1\|8576035_8576764_-\|Tellurium-resistance	unknown	unknown	gnl\|CDD\|226595

Protein	Function_ID	Function_description	E-value
NC_015957.1\|WP_014060332.1\|8562613_8563576_+\|ATP-grasp-ribosomal-peptide-maturase	gnl\|CDD\|275040	TIGR04187, conserved_hypothetical_protein, ATP-grasp ribosomal peptide maturase, SAV_5884 family. Members of this protein family are ATP-grasp ligase family enzymes that regularly occur in a contexts with a methyltransferase and a putative ribosomally translated post-translationally modified peptide precursor. Because of this conserved gene neighborhood and close sequence similarity to ATP-grasp enzymes from microviridin/marinostatin biosynthesis cassettes, this enzyme is suggested also to serve as a peptide maturase.	9.64277e-129
NC_015957.1\|WP_014060346.1\|8579692_8580151_-\|peroxiredoxin	gnl\|CDD\|239316	cd03018, PRX_AhpE_like, Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater similarity to 2-cys PRXs than 1-cys PRXs. PRXs are thiol-specific antioxidant (TSA) proteins that confer a protective role in cells through their peroxidase activity in which hydrogen peroxide, peroxynitrate, and organic hydroperoxides are reduced and detoxified using reducing equivalents derived from either thioredoxin, glutathione, trypanothione and AhpF. The first step of catalysis is the nucleophilic attack by the peroxidatic cysteine on the peroxide leading to the formation of a cysteine sulfenic acid intermediate. The absence of a resolving cysteine suggests that functional AhpE is regenerated by an external reductant. The solution behavior and crystal structure of AhpE show that it forms dimers and octamers.	7.91738e-79
NC_015957.1\|WP_043237024.1\|8565087_8566485_+\|hypothetical-protein	gnl\|CDD\|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	1.38516e-05
NC_015957.1\|WP_014060327.1\|8559883_8561134_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	9.3877e-08
NC_015957.1\|WP_014060338.1\|8568863_8569724_-\|hypothetical-protein	gnl\|CDD\|319822	cd07520, HAD_like, uncharacterized family of the haloacid dehalogenase-like (HAD) hydrolase superfamily. The haloacid dehalogenase-like (HAD) hydrolases are a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members include 2-L-haloalkanoic acid dehalogenase (C-Cl bond hydrolysis), azetidine hydrolase (C-N bond hydrolysis); phosphonoacetaldehyde hydrolase (C-P bond hydrolysis), phosphoserine phosphatase and phosphomannomutase (CO-P bond hydrolysis), P-type ATPases (PO-P bond hydrolysis) and many others. Members are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	4.86161e-11
NC_015957.1\|WP_050993826.1\|8562324_8562588_+\|putative-ATP-grasp-modified-RiPP	gnl\|CDD\|275039	TIGR04186, conserved_hypothetical_protein, putative ATP-grasp target RiPP. A RiPP is a ribosomally produced, post-translationally modified peptide. This family regularly occurs next to ATP-grasp enzymes related to those of microviridin maturation and next to a methyltransferase.	1.4081e-09
NC_015957.1\|WP_014060335.1\|8566550_8566787_+\|zinc-ribbon-domain-containing-protein	gnl\|CDD\|274226	TIGR02605, CxxC_CxxC_SSSS, putative regulatory protein, FmdB family. This model represents a region of about 50 amino acids found in a number of small proteins in a wide range of bacteria. The region begins usually with the initiator Met and contains two CxxC motifs separated by 17 amino acids. One member of this family is has been noted as a putative regulatory protein, designated FmdB (SP:Q50229, ). Most members of this family have a C-terminal region containing highly degenerate sequence, such as SSTSESTKSSGSSGSSGSSESKASGSTEKSTSSTTAAAAV in Mycobacterium tuberculosis and VAVGGSAPAPSPAPRAGGGGGGCCGGGCCG in Streptomyces avermitilis. These low complexity regions, which are not included in the model, resemble low-complexity C-terminal regions of some heterocycle-containing bacteriocin precursors. [Regulatory functions, DNA interactions].	1.62701e-11
NC_015957.1\|WP_014060350.1\|8585440_8585875_-\|hypothetical-protein	gnl\|CDD\|377188	pfam03995, Inhibitor_I36, Peptidase inhibitor family I36. This domain is currently only found in a small set of S. coelicolor secreted proteins. There are four conserved cysteines that probably form two disulphide bonds. Proteins 2SCK31.15C and SCO3675 also have probable beta-propellers at their C-termini. This family includes Streptomyces nigrescens SmpI, a known peptidase inhibitor of known structure. This protein has a crystallin like fold pfam00030 and is distantly related by sequence. It is not known whether other members of this family are peptidase inhibitors.	0.000397136
NC_015957.1\|WP_014060337.1\|8568045_8568708_-\|SAM-dependent-methyltransferase	gnl\|CDD\|366722	pfam01596, Methyltransf_3, O-methyltransferase. Members of this family are O-methyltransferases. The family includes catechol o-methyltransferase, caffeoyl-CoA O-methyltransferase and a family of bacterial O-methyltransferases that may be involved in antibiotic production.	8.33706e-59
NC_015957.1\|WP_014060345.1\|8579016_8579592_-\|TerD-family-protein	gnl\|CDD\|376767	pfam02342, TerD, TerD domain. The TerD domain is found in TerD family proteins that include the paralogous TerD, TerA, TerE, TerF and TerZ proteins It is found in a stress response operon with TerB and TerC. TerD has a maximum of two calcium-binding sites depending on the conservation of aspartates. It has various fusions to nuclease domains, RNA binding domains, ubiquitin related domains, and metal binding domains. The ter gene products lie at the centre of membrane-linked metal recognition complexes with regulatory ramifications encompassing phosphorylation-dependent signal transduction, RNA-dependent regulation, biosynthesis of nucleoside-like metabolites and DNA processing linked to novel pathways.	1.51358e-119
NC_015957.1\|WP_014060341.1\|8574733_8575945_+\|stress-protein	gnl\|CDD\|376767	pfam02342, TerD, TerD domain. The TerD domain is found in TerD family proteins that include the paralogous TerD, TerA, TerE, TerF and TerZ proteins It is found in a stress response operon with TerB and TerC. TerD has a maximum of two calcium-binding sites depending on the conservation of aspartates. It has various fusions to nuclease domains, RNA binding domains, ubiquitin related domains, and metal binding domains. The ter gene products lie at the centre of membrane-linked metal recognition complexes with regulatory ramifications encompassing phosphorylation-dependent signal transduction, RNA-dependent regulation, biosynthesis of nucleoside-like metabolites and DNA processing linked to novel pathways.	4.3319e-63
NC_015957.1\|WP_014060348.1\|8581193_8583923_+\|pyruvate-dehydrogenase-(acetyl-transferring),-homodimeric-type	gnl\|CDD\|236500	PRK09405, aceE, pyruvate dehydrogenase subunit E1; Reviewed.	0
NC_015957.1\|WP_014060347.1\|8580280_8580721_-\|DUF3052-domain-containing-protein	gnl\|CDD\|378615	pfam11253, DUF3052, Protein of unknown function (DUF3052). This family of proteins with unknown function appears to be restricted to Actinobacteria.	5.03269e-68
NC_015957.1\|WP_014060343.1\|8577012_8578206_-\|DUF475-domain-containing-protein	gnl\|CDD\|237583	PRK14013, PRK14013, hypothetical protein; Provisional.	4.34444e-169
NC_015957.1\|WP_014060344.1\|8578258_8578834_-\|TerD-family-protein	gnl\|CDD\|376767	pfam02342, TerD, TerD domain. The TerD domain is found in TerD family proteins that include the paralogous TerD, TerA, TerE, TerF and TerZ proteins It is found in a stress response operon with TerB and TerC. TerD has a maximum of two calcium-binding sites depending on the conservation of aspartates. It has various fusions to nuclease domains, RNA binding domains, ubiquitin related domains, and metal binding domains. The ter gene products lie at the centre of membrane-linked metal recognition complexes with regulatory ramifications encompassing phosphorylation-dependent signal transduction, RNA-dependent regulation, biosynthesis of nucleoside-like metabolites and DNA processing linked to novel pathways.	8.18834e-119
NC_015957.1\|WP_014060340.1\|8573308_8574499_-\|HpcH/HpaI-aldolase/citrate-lyase-family-protein	gnl\|CDD\|379744	pfam15617, C-C_Bond_Lyase, C-C_Bond_Lyase of the TIM-Barrel fold. This family of TIM-Barrel fold C-C bond lyase is related to citrate-lyase. These genes are found in the biosynthetic operon, with other enzymatic domains, associated with the Ter stress response operon and are predicted to be involved in the biosynthesis of a ribo-nucleoside involved in stress response.	1.25368e-170
NC_015957.1\|WP_014060333.1\|8563572_8564709_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|275041	TIGR04188, conserved_hypothetical_protein, methyltransferase, ATP-grasp peptide maturase system. Members of this protein family are predicted SAM-dependent methyltransferases that regularly occur in the context of a putative peptide modification ATP-grasp enzyme (TIGR04187, related to enzymes of microviridin maturation) and a putative ribosomal peptide modification target (TIGR04186).	4.64757e-99
NC_015957.1\|WP_014060342.1\|8576035_8576764_-\|Tellurium-resistance	gnl\|CDD\|226595	COG4110, COG4110, Uncharacterized protein involved in stress response [General function prediction only].	8.1523e-51

>NC_015957.1|WP_014060338.1|8568863_8569724_-|hypothetical-protein
MSVLVASDLDRTLIYSAAALGLDMPDAEAPRLLCVETYEGRPLSYMTETAAGLLAELVRTSVFVPTTTRTVEQYRRIRLPGPASRFAICANGGQLLVNGEPDADWHQRVRTALGDQCAPLEEVRAHLSATADPAWLLKERVAEELFAYLVVERELLPQGYVKELTQWAEPRGWTVSLQGRKIYAVPKPLTKSAAVAEIRNRTGADEVLAAGDSLLDTDLLLAADRAWRPGHGELADAGWTAPRVTVVEETGVAAGEAIVRALGERSSVTWARARSQVIRAVSRGRD
>NC_015957.1|WP_014060337.1|8568045_8568708_-|SAM-dependent-methyltransferase
MAESKSTPITAELYDYVLRHNPPLDPVLRELVEVTHRSLPQQAGMQSAEEQAPLLAFLVRLTGARHIVEVGTFTGFSALAMAQALPADGRLIACDVSEEWTAYGRKAWAKAGVEARIDLRIAPALDTLRAMPAEPHIDLAYLDADKPNYIPYWEELVPRMNPGGLIVADNVFYHGAVTAPEPSTAGAAIQAFNDHVAADVRMEAVMLTVADGLTLARRLG
>NC_015957.1|WP_014060335.1|8566550_8566787_+|zinc-ribbon-domain-containing-protein
MPRYEYRCRACGTTFELNRPMAESSAPASCPDGHDDTVKLLSTVAVTGASSSSARPPSGGGGGGGGGGGGCCGGGCCG
>NC_015957.1|WP_043237024.1|8565087_8566485_+|hypothetical-protein
MAATSAESARPSRESARPGARGRRSGRPSVLGLMLLPVPLLAVVGALSFAGGSGGRRWFGGRGESQRAEAQAAKDAAAAAFYELDTAQRDLRISIETITAVDDSPAARRTAADFSALGQRIDQVSRDYITAVDAHDLDRDDLDSATASRARTDLTRAKDALERTKADLDRFAQGLGPLLEQAETRLARLAPAVERARQALLAASNALDAVRASGLRADDLAARLAALSPELTKLNQGAGQHGVQETLRRADDVLRGAEAVRGEAERLPERSAEIDKRLVSLRTRAQAITTRAAGVEPVLSELRRRYSAACWQDLQTVPAQAARDVAQAEEKLKEAQAAREEQRWPDATALLATVRALLNSTDEAVSAAGDRLRRLDEVSFDQQKEIERTRFAIRDAQRLAMAGRSTPDPRHARPLDDAVERLERAIAGLEGRHPDWWHFLSETEAVRQTAARVVQGIREERGGGH
>NC_015957.1|WP_014060333.1|8563572_8564709_+|methyltransferase-domain-containing-protein
MITEVPTADELRRHMTEQLESTGSIRSAVWRAAFLNVPRHTFVPDFTLRSQGRLHEYSQGDPAWLAAAYSDVSLLTQFDQDGTATSSSTQPSLMAQMLESLGVRDGDTVLEIGAGTGYNAALLSHRLGPDHVVTVDVDPELVAAAAARLRQAGYEPTLVAGDGTAGHPERAPYDRLLATCGVGRIPDAWRQQVHAGGVVVANIGFGIARLAIAADHSAGGKFLPGLATFMTARPTPDATGTTAKRLVQPMLTWSGQTREITAPVVLDAPGAQFLASLLHPQVNDFALVDDEGRQIRCLFDPVTSSWARITMTGVMAARLDHGGPRDLWAEREPLLTQWRDAGRPGHQRYGLTVSSEGVHTLWLDEPDGVGWRLPDWRP
>NC_015957.1|WP_014060332.1|8562613_8563576_+|ATP-grasp-ribosomal-peptide-maturase
MTVLVLTRPQDATADLVIAELNERSVPVCRLDPGDFPEALTMAARIGPGRTPWEGVLHGQHRDVSLGDIRSVYYRRPAAFRLHPDMSEQDARWAQAEAQAGFGGLLYSLPCLWVNHPHRNALAAWPPVALATAARGGLSVPLSLITNDPGEAREFVSALPGQVAAYKAIGTTHPSDHDDRPQALWTTQVRPGEIGESVRRTAHQFQEWVDKAYEVRLTAIAHSLFAAEIHAGSDASRLDFRADYDSLTYKPCQVPEHIAQGVHALTFTFGLRYVALDFLVNPQGRWYLIDVNPNGQWGFIPDLRAPITRALADLLERANP
>NC_015957.1|WP_050993826.1|8562324_8562588_+|putative-ATP-grasp-modified-RiPP
MENAVTLTMERTQTHPAVRPFGLSKAVPVADEKLTLPALHLCPERQMSVTAAGVPFIHEPSMKSQITTTTQTREDSQLATDTENDTD
>NC_015957.1|WP_014060330.1|8561998_8562142_+|hypothetical-protein
MRHRRQDPAVRAALLAYRAVRLGLLLSVIPALLVLAIYLCIAGDPYR
>NC_015957.1|WP_043237023.1|8561232_8561826_+|hypothetical-protein
MNPQVLPWTPPNNEDVEALPAGKWWDAVRAQPTVGERAVQLLGDETGAVIQDKHGPLYWLVQVGSATSCHLRQVRVLTKLTDECTYLGVPPVSWTEGPSTHWRVPLSADHYLTDAFKLWGALAEADRAALGPVPQGRQTCYRCELPTDEPVIVDVQHGGSGAGRTVYACPPHARAYQRDVVAEAAAMRRALNRGRAR
>NC_015957.1|WP_014060327.1|8559883_8561134_+|helix-turn-helix-transcriptional-regulator
MSSDAPPDPLDHPLVFGQRMQVLRTRRGMSRTVLAGLLGKSPSWVKQIENGVLHTPGLPMILRIAEVLRVRDLAELTGDQTMPIDLFIGPGHAKLPAVRAAIDAFPLATDREAPSAAHLSARLESAWAARHSSPNHREVIGGLLPDLIRDAQLAVRQADRAPERRVAQAVLAEVYSLSQFFIAYQPDSALLWRVAERGMVAAQESEDPHAIGMAAWLTAQAHRDSGHAHFDAADAVTLETLRYLTPLLPDGPEDVCAIAGALQFEAGYTAARRGDTGTAWGFWDTARKMAEKLPADYYHPMTSFSRAIMGAHAVTVAVELHAGGESVRQAANADARTIRSRPRRARHRIEEARGYQLDGQSETALATLDKAYEAAPETIRYNGYARRIILEETESKSPTHRRRAAELAVKIGVLTA
>NC_015957.1|WP_014060340.1|8573308_8574499_-|HpcH/HpaI-aldolase/citrate-lyase-family-protein
MRHFGHLTDEVRANVFHQEPGEFSVDSPARTLAVALGATLYCPATRPKLAEDIVKQAGRGVVSMVLCLEDSIDDAEVPGAEENLIRQFAELSGLGPGTTPLPLLFIRVRTPEQIVDLLNRFGSGVRLLSGFVLPKFTEERGGAFLEALMSAENAQVTEALGGRRLFAMPVLESPELMHRETRTDTLSGISRIVDKYRERVLALRLGVTDLCSAYGLRRAPDMTAYDVQLIASVIADVVNMLGRADGTGFTITGPVWEYFKPHERMFKPQLRISPFSSGRAEALRTALIEHHMDGLLREIELDRANGLQGKTCIHPTHVAPVHALSVVSHEEFSDAVDILEPQRCGGGVVRSSYTNKMNEVKPHRAWAERTLRRAEVFGVAREDVSFVELLAASLRT
>NC_015957.1|WP_014060341.1|8574733_8575945_+|stress-protein
MTQAMLKGSNIPLEATAIRAVLRWTPGTDVPDVDASALLLDADDRVRSDEDFVFYNQPNHPSGLVRHLPKKPNQGTLTDTIEAEFSGLEPGVRRVVLAASADGGTFGQVRDLSLLLYDASSGAPREADAEPLAIFAVLPETGKEAALICGELYRRGDTWKFRALGQGYETGLVGLATQYGISVEDGEAAGGSDGDGAAAPAGREGGTAPEPPVAPAPAPEPLTVDAPEPLAAAPEPLTAPEPPATATPAAPPSAATHAPPAAPGTPPPSSSDAPTRPHSPSPAYGYPHAASPDPWDPHRTQPMQPPTAHGDSGFGYVPPQAPPPPPQAPAAGYPQPPGQAPAQPGYGYPPQQQTYGYPQSPAYGYPQQVQPTGPVAPPPLPIPVQVPDPQFVLPPQGPQFQNR
>NC_015957.1|WP_014060342.1|8576035_8576764_-|Tellurium-resistance
MAFWSNWGRSAWREFESGDASGVVELTKRQSTISLTKQGAASGNLRINLSWQMRTSDFNSRAARGSLRHPLRMFKPEPVQAQGPAMVNVDLDLAVMYELKSGSKGVVQPLGEFFGNLNEAPYVKLSGDDRFGSGSGETVYVNMDHKDDIKRLLVFVYIYDGTPAFDRTHGLVTLYPSNGPRVEIALDERAPQARSCAVVLIENVKGEMMVRREVKYVYGFQAELDRLYGWGLQWGRGYKSKV
>NC_015957.1|WP_014060343.1|8577012_8578206_-|DUF475-domain-containing-protein
MLLKTFGWSFAITVIGLALAGVLWGWKGLAIVGILSILEISLSFDNAVINAGILRKMNAFWQKIFLTVGVLIAVFGMRLVFPVIIVAITAKLSPLQAVDLAINNKDKYEHLVTAAHPAIAAFGGMFLLMIFLDFIFEERDIRWLGWLEKPLAKLGRLDTFSVVVALVVLLISATTVATDVAHGGGDKSSTVLLAGVAGLVTYLIVGGISSYFEDKLEEEEEDDEDEEAAKGADESGEETKSAANAQLNGSGGRGSSGATVVGLAGKAAFFLFLYLEVIDASFSFDGVIGAFAITNDIFEMALGLGIGAMYIRSLTVFLVRRGTLDDYVYLEHGAHYAIGALAGILLVTIKYEINEVITGLVGVVLIGASYWSSVVRNRRVAAEGEGSETKTEVTSGV
>NC_015957.1|WP_014060344.1|8578258_8578834_-|TerD-family-protein
MGVTLAKGGNVSLSKAAPNLTHVLIGLGWDARSTTGAPFDLDASALLCQSGRVLGDEYFIFYNNLKSPEGSVEHTGDNLTGEGEGDDESLLIDLVKVPAEVDKIAFPVSIHDADTRRQTFGQVSNAFIRVVNQADGQELARYDLSEDASGETAMIFGEVYRYGGEWKFRAVGQGYASGLRGIALDFGVNVS
>NC_015957.1|WP_014060345.1|8579016_8579592_-|TerD-family-protein
MGVSLSKGGNVSLTKEAPNLTAVVVGLGWDARTTTGTDFDLDASALLTNTEGKVGNDQNFVFFNNLKSPDGSVEHTGDNITGEGEGDDEQIKVNLAGVPADVAKIVFPVSIYDAETRQQSFGQVRNAFIRVVNQADGQELARYDLSEDASTETAMVFGELYRNGAEWKFRAIGQGYASGLRGIAQDFGVNV
>NC_015957.1|WP_014060346.1|8579692_8580151_-|peroxiredoxin
MSIEVGTKAPDFQLKNQHGESVKLSDFRGEKNVVLLFYPFAFTGVCTGELCALRDELPTFVNDEVQLLAVSNDSPFSLRVFAEQEGLEYPLLSDFWPHGETSRAYGVFDEDKGCAVRGTFVIDKEGVVRWTIVNGLPDARDLNDYVKALETL
>NC_015957.1|WP_014060347.1|8580280_8580721_-|DUF3052-domain-containing-protein
MSATADHAEERTNPAARLGFQPEQVVQEIGYDDDVDQELRESIEEITGQELVDEEYDDVADAVVLWFREDDGDLTDALVDAIQMIDDGAPVWLLTPKTGRDGYVEPSDINEAATTAGLSQTKSFNAGKDWTGSRLVTPKAARSGKR
>NC_015957.1|WP_014060348.1|8581193_8583923_+|pyruvate-dehydrogenase-(acetyl-transferring),-homodimeric-type
MASGSDRNPIIIGGLPSQVPDFDPEETQEWLDSLDAAVDERGRERARYLMLRLIERAREKRVAVPEMRSTDYVNTIATKSEPFFPGNEEIERKVLNATRWNAAVMVSRAQRPGIGVGGHIATFASSASLYDVGFNHFFRGKDHDSGDQIFFQGHASPGIYARAFLLDRLSEDHLDGFRQEKSKLGHALSSYPHPRSMPDFWEFPTVSMGLGPLGAIFQARMNRYMEARGVADTSNSHVWAFLGDGEMDEPESLGQLSLAAREGLDNLTFVVNCNLQRLDGPVRGNGKIIQELESQFRGAGWNVIKLVWDRTWDPLLAQDRDGILVNKLNTTPDGQFQTYATETGGYIRDHFFGEDQRLRKMVEGMTDDQILHLGRGGHDHKKIYAAYAAAKAHKGQPTVILAQTVKGWTLGPNFEGRNATHQMKKLTVDDLKRFRDRLHLPIPDQELESGLPPYYHPGRDSEEIQYMHDRRKALGGYAPTRVVRAKPLQLPGDKTYATLKKGTGQQSIATTMAFVRLLKDLMRDKEIGKRFVPIAPDEYRTFGMDSLFPSAKIYSPLGQTYESVDRELLLAYKESPTGQMLHDGISEAGCTASLIAAGSAYATHGEPLIPVYVFYSMFGFQRTGDQFWQMADQLARGFVLGATAGRTTLTGEGLQHADGHSQLLASTNPAVVAYDPAYGFEIAHIVQDGLRRMYGENSEDVFYYLTVYNEPIQHPAEPENVDREGILKGLYRYRQSEEGAIPAQILASGVAVPWAIEAQRILAEDWNVKADVWSATSWNELRRDAVEAEEHNLLHPEEEQRVPYVTRKLADAEGPKVAVSDWMRAVPDQIARWVPGTYQSLGADGFGFADTRGAARRFFHIDAESIVLGVLTELARDGKIDRSALKQAIDRYQLLDVAAADPGPAGGDA
>NC_015957.1|WP_014060350.1|8585440_8585875_-|hypothetical-protein
MRKIIKAAVSAVALTATLAATLAPAATATAATATATATGTSATGRAAAAPPRLGNCAAGQLCLWRSGGFTGARQTHELAGVDIESCVPLPSGTTAASLANRTGRPVTAYQSGECAETAEFRTYPTGSWAPETPYQVRAFKIWER

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Crispr_ID: NC_015957_20

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015957_20

8641629-8641735

Orphan

Consensus_repeat	Method
GGCCTTGCCGATGCTGCCCGAGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015957_20

>merge|NC_015957|20|8641629-8641735|CRISPRCasFinder
GGCCTTGCCGATGCTGCCCGAGCCGTACTGCTGAATATGGTCGCCGTTCATGATCCCCCGATGCTCCCGCTGCCGCTGTGACGGGCCTTGCCGATGCTGCCCGCGCC

>NC_015957|20|19|8641629-8641735|CRISPRCasFinder
GGCCTTGCCGATGCTGCCCGAGCC	GTACTGCTGAATATGGTCGCCGTTCATGATCCCCCGATGCTCCCGCTGCCGCTGTGACG
GGCCTTGCCGATGCTGCCCGCGCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015957.1\|WP_014060389.1\|8630563_8630881_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|378968
NC_015957.1\|WP_078505864.1\|8635983_8637003_-\|pectate-lyase	unknown	unknown	gnl\|CDD\|226384
NC_015957.1\|WP_014060407.1\|8650408_8651056_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
NC_015957.1\|WP_014060399.1\|8644614_8644797_+\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014060400.1\|8644877_8645897_-\|NADP-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|176190
NC_015957.1\|WP_014060401.1\|8645985_8646414_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NC_015957.1\|WP_150112941.1\|8626406_8628497_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227308
NC_015957.1\|WP_014060405.1\|8649227_8649851_+\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014060398.1\|8644001_8644400_-\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014060395.1\|8638300_8639827_-\|alpha-N-arabinofuranosidase	unknown	unknown	gnl\|CDD\|226064
NC_015957.1\|WP_014060388.1\|8628693_8629029_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379188
NC_015957.1\|WP_014060402.1\|8646448_8647333_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237171
NC_015957.1\|WP_014060403.1\|8647464_8648331_-\|SMP-30/gluconolactonase/LRE-family-protein	unknown	unknown	gnl\|CDD\|369882
NC_015957.1\|WP_014060406.1\|8649825_8650251_-\|OsmC-family-peroxiredoxin	unknown	unknown	gnl\|CDD\|274650
NC_015957.1\|WP_014060386.1\|8625544_8626339_+\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133378
NC_015957.1\|WP_078505506.1\|8637436_8638228_+\|intradiol-ring-cleavage-dioxygenase	unknown	unknown	gnl\|CDD\|239540
NC_015957.1\|WP_014060404.1\|8648327_8649104_-\|IclR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224332
NC_015957.1\|WP_043240874.1\|8634179_8635904_+\|histidinol-phosphatase	unknown	unknown	gnl\|CDD\|197753
NC_015957.1\|WP_014060390.1\|8630979_8631861_+\|NAD(P)H-binding-protein	unknown	unknown	gnl\|CDD\|187578
NC_015957.1\|WP_014060391.1\|8631918_8632722_-\|membrane-protein	unknown	unknown	gnl\|CDD\|179898

Protein	Function_ID	Function_description	E-value
NC_015957.1\|WP_014060389.1\|8630563_8630881_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|378968	pfam12840, HTH_20, Helix-turn-helix domain. This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.	1.22965e-07
NC_015957.1\|WP_078505864.1\|8635983_8637003_-\|pectate-lyase	gnl\|CDD\|226384	COG3866, PelB, Pectate lyase [Carbohydrate transport and metabolism].	3.32209e-61
NC_015957.1\|WP_014060407.1\|8650408_8651056_-\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	5.23352e-60
NC_015957.1\|WP_014060400.1\|8644877_8645897_-\|NADP-dependent-oxidoreductase	gnl\|CDD\|176190	cd05288, PGDH, Prostaglandin dehydrogenases. Prostaglandins and related eicosanoids are metabolized by the oxidation of the 15(S)-hydroxyl group of the NAD+-dependent (type I 15-PGDH) 15-prostaglandin dehydrogenase (15-PGDH) followed by reduction by NADPH/NADH-dependent (type II 15-PGDH) delta-13 15-prostaglandin reductase (13-PGR) to 15-keto-13,14,-dihydroprostaglandins. 13-PGR is a bifunctional enzyme, since it also has leukotriene B(4) 12-hydroxydehydrogenase activity. These 15-PGDH and related enzymes are members of the medium chain dehydrogenase/reductase family. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES.	0
NC_015957.1\|WP_014060401.1\|8645985_8646414_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	4.54635e-14
NC_015957.1\|WP_150112941.1\|8626406_8628497_-\|hypothetical-protein	gnl\|CDD\|227308	COG4974, XerD, Site-specific recombinase XerD [DNA replication, recombination, and repair].	0.00968808
NC_015957.1\|WP_014060390.1\|8630979_8631861_+\|NAD(P)H-binding-protein	gnl\|CDD\|187578	cd05269, TMR_SDR_a, triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs. TMR is an atypical NADP-binding protein of the SDR family. It lacks the active site residues of the SDRs but has a glycine rich NAD(P)-binding motif that matches the extended SDRs. Proteins in this subgroup however, are more similar in length to the classical SDRs. TMR was identified as a reducer of triphenylmethane dyes, important environmental pollutants. This subgroup also includes Escherichia coli NADPH-dependent quinine oxidoreductase (QOR2), which catalyzes two-electron reduction of quinone; but is unlikely to play a major role in protecting against quinone cytotoxicity. Atypical SDRs are distinct from classical SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.13593e-60
NC_015957.1\|WP_014060395.1\|8638300_8639827_-\|alpha-N-arabinofuranosidase	gnl\|CDD\|226064	COG3534, AbfA, Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism].	0
NC_015957.1\|WP_014060388.1\|8628693_8629029_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|379188	pfam13443, HTH_26, Cro/C1-type HTH DNA-binding domain. This is a helix-turn-helix domain that probably binds to DNA.	1.57505e-12
NC_015957.1\|WP_014060403.1\|8647464_8648331_-\|SMP-30/gluconolactonase/LRE-family-protein	gnl\|CDD\|369882	pfam08450, SGL, SMP-30/Gluconolaconase/LRE-like region. This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyze diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.	9.47534e-92
NC_015957.1\|WP_014060406.1\|8649825_8650251_-\|OsmC-family-peroxiredoxin	gnl\|CDD\|274650	TIGR03562, osmo_induc_OsmC, peroxiredoxin, OsmC subfamily. pfam02566, OsmC-like protein, contains several deeply split clades of homologous proteins. The clade modeled here includes the protein OsmC, or osmotically induced protein C. The member from Thermus thermophilus was shown to have hydroperoxide peroxidase activity. In many species, this protein is induced by stress and helps resist oxidative stress. [Cellular processes, Detoxification].	1.45554e-63
NC_015957.1\|WP_014060386.1\|8625544_8626339_+\|MerR-family-transcriptional-regulator	gnl\|CDD\|133378	cd00592, HTH_MerR-like, Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators. Helix-turn-helix (HTH) MerR-like transcription regulator, N-terminal domain. The MerR family transcription regulators have been shown to mediate responses to stress including exposure to heavy metals, drugs, or oxygen radicals in eubacterial and some archaeal species. They regulate transcription of multidrug/metal ion transporter genes and oxidative stress regulons by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	3.44209e-22
NC_015957.1\|WP_078505506.1\|8637436_8638228_+\|intradiol-ring-cleavage-dioxygenase	gnl\|CDD\|239540	cd03457, intradiol_dioxygenase_like, Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the extradiol-cleaving enzymes which break the C2-C3 or C1-C6 bond and utilize Fe2+ and Mn+. The family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases. The specific function of this subgroup is unknown.	2.04336e-77
NC_015957.1\|WP_014060404.1\|8648327_8649104_-\|IclR-family-transcriptional-regulator	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	1.45547e-69
NC_015957.1\|WP_043240874.1\|8634179_8635904_+\|histidinol-phosphatase	gnl\|CDD\|197753	smart00481, POLIIIAc, DNA polymerase alpha chain like domain. DNA polymerase alpha chain like domain, incl. family of hypothetical proteins.	1.63998e-09
NC_015957.1\|WP_014060402.1\|8646448_8647333_-\|hypothetical-protein	gnl\|CDD\|237171	PRK12678, PRK12678, transcription termination factor Rho; Provisional.	7.29693e-06
NC_015957.1\|WP_014060391.1\|8631918_8632722_-\|membrane-protein	gnl\|CDD\|179898	PRK04949, PRK04949, putative sulfate transport protein CysZ; Validated.	1.65949e-24

>NC_015957.1|WP_014060395.1|8638300_8639827_-|alpha-N-arabinofuranosidase
MPQIPSASAPASARFTLDPAFAVGEVNPRLFGSFVEHLGRCVYTGIHEPGHPAADEAGLRTDVLALIRELGVSVIRYPGGNFVSGYKWEDGVGPVESRPRRLDLAWRSTETNRFGLSEYIDFVRKVDGEPMMALNLGTRGVAEALELQEYANHPSGTALADLRIGHGDKDPYGIGLWCLGNEMDGPWQTGHKTAEEYGRLAAETARAMRQIDPDVELVACGSSNQSMPTFATWEATVLQETYDLVDHISLHAYYEERDGDRGSFLASAVDMESFIENVVATCDHIGARLKSKKKINLSFDEWNVWYQTHYHNAEPLNWEEAPRLLEDNYSVTDAVVVGSLLIALLRHADRVTVACLAQLVNVIAPIMTEPGGPAWRQTTFYPFAQASAHGRGRVLQVNVDSPAYETAVYGEVPLLHATAVLDESTGAVTVFAVNRDQHRPLPLEIALHALPVTRVVEHTVLADADPEARNTLTDPERVTPHPGEGTALADGALRTTLEPMSWNVIRLA
>NC_015957.1|WP_078505506.1|8637436_8638228_+|intradiol-ring-cleavage-dioxygenase
MLMTDLSSAPMGRRRVLVAGSAAAAAIGIGAGTAAARPETASTATRNTGAAAARDAAAICTLTKELTEGPYYLDHALVRANVTEDKKGVPLQLALTVVDTATCAPLNKALAEIWYCDALGEYSGFVGNNGHQEPDNGKFLRGAVLTGTDGVANLTGIYPGWYRGRCIHVHLKVHTDVTLTSDGSFTGGNEIHTGQLFFDEKITEAVAKLSPYSTNTVPRTPLSADGIYGNGGTAAGLLTVTALGSTPSAGYRGTLTVGVDPDA
>NC_015957.1|WP_078505864.1|8635983_8637003_-|pectate-lyase
MTAVAAGVTAALALGGLSTVSAHDADSTDSARSESTRTAAAGSATAARLAVETTPIGFGAGTTGGGNATATTVISLDAFKTAVTGDKAKVVKVSGLFSLTGQVDIGSNTTVLGVGSGSGFTGGGLRLKEATNVIVRNLNLGKPRKPSDAITVQKSTRVWIDHNTLSADRDHDKDYYDGLLDISHGSDNITVSWNRFADHFKGSLVGHSDNNASEDTGHLKVTYHHNWFANVYSRIPSLRFGTGHFYDNYVQGAETGVHSRMGAQTLVENNVFRDTEVAVTTSRDSDIDGYAVLRGNDLGGAATEVSQTGGFTTPPYAYTAEPASSVVASVTAQAGAGKL
>NC_015957.1|WP_043240874.1|8634179_8635904_+|histidinol-phosphatase
MAPGHHHPHDEHAVHSLPPALDPSVRDEELTPDQLSRRSMLRRAGLLGAGLGAVSVLDGGATRAVAATRAAPGSRQHGGGYLWLAGDHHIHTQYSNDGKYRVIDQVRQGARHGLDWMVITDHGNITHARIGVEKVNPDIREARETHRDALVFQGLEWNIPGAEHGTVFVHPGRDEVAVLKEFETSFDGSVKNAGDSTPRNEALAIAGLDFLSDAVRRRRVKAALMLANHPARKGLDSPHEIRGWRDAQPHIAVGMEGAPGHQAAGIPASAHGPGGARGLYENAPGPQSFTAYPAESYRTWGGFDWMTATVGGLWDSLLAEGKPWWITANSDSHNVYADTAMRRPGSDYETNGRQDDPVYRGGLDLEENDYWPGQYSRTHVGAEDFSYAAVMDGIRAGRVWVDHGGLISGLDARLSGGGSGGERRSGSGGGGRSVTLGGTLQVERGTRVRLDMDIALANGPNWAGFIPTLARVDVIQGEVTGAVGDRDTFTTPRTRVVKSFEISRTSGSVRLSYDLGAVDRPLYVRLRGTDGNRAAVGARGAAVDPHGPAMDVPGDADPWRDLWFYANPMWVLPS
>NC_015957.1|WP_014060391.1|8631918_8632722_-|membrane-protein
MRDLVNGFGYLMKGQRWAARHGRWWGFGMIPALITLVGYAAALVALFFWTDDVIAWATPFADDWSSPWLGIFRGALTILFAATCLFLAVLTFTAVTLLVGQPFYESLSEQVDRSEGGAVPDSGLSIWAELWIGLREAIGLLIRVTLWSVLLFALGFIPGVGQTVIPALAFCVTGFFLTEELTSIALLRRGILLKERRRMLRSRRLLALGFGVPLSLLFLLPLVAVFLMPGAVAGATLLVRDLTGENEDAAPQGETAAGPAGAFNGAS
>NC_015957.1|WP_014060390.1|8630979_8631861_+|NAD(P)H-binding-protein
MSEQAHATVAVTGVTGALGSRIAARLAERGVPQLLVGRDPSRIPELPGAQRRGPAEYADAAAMRTALTGASTLVLISGHPTGRRLEEHAGAVEAGMAVGVERVLYVSLLGAAPTATYRNARDHWLTEQFLALAGVRHTVFRAGFYASTPAALADDELVVSGPGGDGRAAFVTHDDIADVIAAVALDEGPRSEHDGATLEVTGPEALTLEEVVARIASATGRPYRYVPETVEEAFARRWRMGISGVQIESWISWYQAIAKGELSAVTDVVPRITGSSATPVERAGWWPAPKTAW
>NC_015957.1|WP_014060389.1|8630563_8630881_-|helix-turn-helix-transcriptional-regulator
MTRESDGPAVAQLELGAVLSALADPHRRRIVTELVIAPEDVERSCSSFQAPVSKSTMTHHFKVLSDSGLIRTTDYGNRKGVTLRRTDLNTRFPGLLDLLASEATP
>NC_015957.1|WP_014060388.1|8628693_8629029_-|helix-turn-helix-transcriptional-regulator
MKWNLRWAAANRGIWRPSELMPVFEEVGFTPSLSKVSALWSGTPVTVRLEDLDLICAALDCTVADLLVAEPVARRTPAVQGEELAKAAGELPRPVPRRPSGAGRPRSLPPN
>NC_015957.1|WP_150112941.1|8626406_8628497_-|hypothetical-protein
MAITEYDAAWYYEPVRAARLPVWTQLSFCLPASIRRPAAPTGTYRLQTDGRYHAPGWARAQRPAAVLDDGRVCPPAVRGQMAMFPAPYRLLDHHAVLLRDRFQGDLERLKPLINEVQTEHRLSRTWRVTATDALALALAARDAAGQDLVDATILDALPHRPSGVAAVLHKSGLLAPDIEHGVVVLPHAQRARPQSQPRSCDHCLSWGRNQVCEACRGWRRIYADQRGCCSRCGAGLLPLRNGRCRDCTRQRRQLGPDTDTSTWRQLRFAGRFLAREGPARRELLADRSEFSPPAVLEGQATIFEIERDWRPLAGALLPAPLPPVKSLLADFARYTTENRWDRSVHESSARVLRVAATWLGADTVFREEDIRAMHRAFGGMGRIRGLVAFLDQREQLVHSPPRRNRHEAFVRRTIAAFPPRISDELGTWVGVLRGTGRSHHRVTDYATLRRYLIYLATALADWTTRYTTLRQVTEPDVKAAVTAVKGPRAHERAVAARSLFRALKHAKLVFVDPTRGLRVTRQELLPTTLAPDRLAGLLETSSNPATRLVLALVALHATSGTDLRNLVLSDVLLTRRQLLIRRPHGRHVVHLDNTTADLLHAWLRYRHQRWPRTVNAHLLVTQQTASATDPVSADYVYRRFDPAGLTLRAVRADRILDEARETEDPVHLVRVFGISITTAMKYIHAAHPHRAGPVPH
>NC_015957.1|WP_014060386.1|8625544_8626339_+|MerR-family-transcriptional-regulator
MLTISQLAAYAGVTVRAVRHYHRIGLLPEPERDRSGYRTYDAVAVVRLIRIRTLADAGVPLARVQELLAAGPEEFAGGVQEIDKALRAEIRRLQDTRSRLARLAAGEHLALPQSVVDYLDRLRGLGVEERYIEMERDAWIMIAAQVPHSIDSVIAKKHEELDDPEMVKLYSLLGGALDWPADDPRIVEVADIMERLMVRAVEAGEVGADDGIDDQFVDLLDSTMVESSPHAARLLAILEERGWRGWTRIERVPAERLNTELSPS
>NC_015957.1|WP_014060398.1|8644001_8644400_-|hypothetical-protein
MSTMAGPEQPRSASQVLVAVSGISRYDAEAVFGVLRSCYESDEATTNLPQDAAEGRPTVWTSVFEVADPRERPRPASLTAPVTADLQGGPRQVQQMADVLAHAFEVREQGAVAGDQERELRLRLSSTGIRPE
>NC_015957.1|WP_014060399.1|8644614_8644797_+|hypothetical-protein
MRTDYALRGADADAGAGDARGAVHRTDDTHALSRVWPARVRDGRLAVALPGRSLTTVVLR
>NC_015957.1|WP_014060400.1|8644877_8645897_-|NADP-dependent-oxidoreductase
MSVIPTTGREWHLVARPQGWPKPEDFALREASISEPGPGQALVRNLYMSVDPYMRGRMNDVKSYTPPFQLDQPMDGGAVGKVIASNAEGLSVGDHVLHFGGWREYATVSAKSAVKVDPEVAPLPAYLGVLGMPGLTAYAGLLEVASFKEGDAVFVSGAAGAVGSEVGQIAKLKGASRVIGSAGSDEKVRVLLDEYGFDAAFNYKKGPVAEQLKEAAPDGIDVYFDNVGGEHLEAAIGRLKVHGRITVCGMISQYNVTEPPAAPRNLAMVIGKRLRMQGMLVGDHQALQGQFFEEVGGWIREGKLHYRETVIKGVENGVDAFLGMLRGENTGKMIVAFED
>NC_015957.1|WP_014060401.1|8645985_8646414_+|MarR-family-transcriptional-regulator
MTSRIDPLTLEVVELIGTIVARYHEEYEEAAAKHSLTGAQARVLGLLSGGPTPMRRLAQQLKCEPSNVTGIVDRLESRGFAERRLDPADRRVKLAAATDAGRETAERLRGSLDFAREPLAELSDEERTVLRDLLKRMLGVTP
>NC_015957.1|WP_014060402.1|8646448_8647333_-|hypothetical-protein
MDYCSPCRRHLNGAVSCPGCGTPAGDLGLPSAASDTAHEGGADTPAPRAERRADRRADRRTGGRADRRTDEHADRHTDRRTDRRTDEPEDGRTGGRAERRAAQASAASGATRASRRKPKPRLFGSRARRARRGRGRRVTIMAAVLGPVLAAVFVAELATEGHWRESSPSPSRQEPVADRSGGVSDSDEPVTQDTTGPSELPSASDSGQALDDASKGKGKDDGKSKDGKDDTSPDPDGGSSSDPSDATSSAPGGPGTTQRPTTPSHPGPTAPATVAPTPTPSPSETCNRFLWWCT
>NC_015957.1|WP_014060403.1|8647464_8648331_-|SMP-30/gluconolactonase/LRE-family-protein
MSTRPSLEIAVRASAVLGEGPTWDAAARRLIWVDILSSRVHTYDPATGRRTTLATEQHVGAAKPRAGGGLVVNLRDGIGMYGADGGFDWLLREAVPGRRGNDAAVAPDGALWAGTMRYDETAGGGTLSRIGADGSPAEFLPGVTVSNGIGWSPDGRLMYYTDTPTRRIDVFDVDDADGPVVASRRPFAEVEKGAGFPDGLCVDADGAVWVALWDGAAIRRYAPDGTLDRVVELPFPRPTACAFGGADLTDLYLTSARVGLGAGAPPLAGSLLVIEGAGQGLAQPAFAG
>NC_015957.1|WP_014060404.1|8648327_8649104_-|IclR-family-transcriptional-regulator
MGRLVPAVTRALDILELFLDGDGTLSAPEITRRLGLPRTTVHELVTTLAARSYLVQVPDQPGRYRLGVRPYQLASRYAEQLDLAAEGRQVARSVAETCDETVHVAILEGMDVIYIAKVDSTHAVRMVSAAGRRLPAHCTSVGKMLLASLPDDALDARLSNEQPLAAMTDNSITSPIELRRHLVTVRERGIAVEQRESNPDVSCVAAPVRDSTGKVVAALSISVPTIRWSEERQAELAELAAKGAGELSVRLGHRRRDI
>NC_015957.1|WP_014060405.1|8649227_8649851_+|hypothetical-protein
MDSAPGSFPRPDSFPTPFPFVLVLLRRMADHQPGLVEDALRELGFGRAVMREANRRWQAMQRSPRRRSAVARYRSVLGAPESTSTRRIGDLTCEALSWSVPLWPDLRFEVLTAPNGAVWNEWLVRAPGAPGPRLRTAADLVPWSCTVDEVARAFAPARPMEGSAPTRWRLAFDAPEAENGELRHYVAEFTWGLLQRLENVRPASPTA
>NC_015957.1|WP_014060406.1|8649825_8650251_-|OsmC-family-peroxiredoxin
MATTRTAHTVWQGNLAQGQGTVTFDSSGIGEQPVSWPSRAEQANGKTSPEELIAAAHSSCFSMALSHGLTQAGNPPTQLTTQADVTFQPGTGITGIHLTVEGTVDGLDEAAFTAAAEDAKKNCPVSQALAGTEITLSAKLA
>NC_015957.1|WP_014060407.1|8650408_8651056_-|histidine-phosphatase-family-protein
MAELVLIRHGETDWSRSRKHTSWTDVPLTPRGEEQARALRPPLAARKIGLTLVSPMARAMRTARLAGLEDLTVEPDLHEWDYGGYEGITTTEIHRTRPDWNLWTDGVPPGGPDHPGESPERIGARVDRVLARIAAELEAADGADVVLVAHAHVLRVLTARRLGLPPSAGALFRLDTATVSRLGTEHGRPAVVAWNVGSESISGQGATGSGGTPAG

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Crispr_ID: NC_015957_21

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015957_21

8694428-8694531

Orphan

Consensus_repeat	Method
TGCTCTGCCAATTGAGCTACAGGGGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015957_21

>merge|NC_015957|21|8694428-8694531|CRISPRCasFinder
TGCTCTGCCAATTGAGCTACAGGGGACCGAGCTCCCCCGACTGGACTCGAACCAGTAACCTGCCGGTTAACAGCCGGCTGCTCTGCCAATTGAGCTACAGGGGA

>NC_015957|21|20|8694428-8694531|CRISPRCasFinder
TGCTCTGCCAATTGAGCTACAGGGGA	CCGAGCTCCCCCGACTGGACTCGAACCAGTAACCTGCCGGTTAACAGCCGGC
TGCTCTGCCAATTGAGCTACAGGGGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_015957.1\|WP_050993831.1\|8692862_8693981_+\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271189
NC_015957.1\|WP_014060449.1\|8707815_8708802_-\|adenosine-deaminase	unknown	unknown	gnl\|CDD\|236480
NC_015957.1\|WP_014060446.1\|8702388_8703750_-\|deoxyguanosinetriphosphate-triphosphohydrolase	unknown	unknown	gnl\|CDD\|235098
NC_015957.1\|WP_167543251.1\|8686229_8686631_-\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_150112948.1\|8686596_8687439_-\|toprim-domain-containing-protein	unknown	unknown	gnl\|CDD\|379044
NC_015957.1\|WP_014060452.1\|8709599_8710295_+\|DUF218-domain-containing-protein	unknown	unknown	gnl\|CDD\|225500
NC_015957.1\|WP_014060441.1\|8694778_8695048_+\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014060445.1\|8700756_8702052_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|170080
NC_015957.1\|WP_106685999.1\|8696861_8697941_-\|RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|235640
NC_015957.1\|WP_014060437.1\|8687684_8688080_-\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_078505518.1\|8692104_8692980_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379665
NC_015957.1\|WP_123060297.1\|8690459_8690630_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225035
NC_015957.1\|WP_014060444.1\|8698722_8700681_-\|DNA-primase	unknown	unknown	gnl\|CDD\|235551
NC_015957.1\|WP_014060442.1\|8695073_8696660_+\|sugar-kinase	unknown	unknown	gnl\|CDD\|198375
NC_015957.1\|WP_167543252.1\|8690616_8691573_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377856
NC_015957.1\|WP_014060439.1\|8689060_8690314_-\|IS256-family-transposase	unknown	unknown	gnl\|CDD\|307151
NC_015957.1\|WP_014060438.1\|8688380_8688950_-\|deaminase-reductase	unknown	unknown	gnl\|CDD\|223340
NC_015957.1\|WP_014060440.1\|8691699_8691909_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	unknown
NC_015957.1\|WP_086019653.1\|8708971_8709286_+\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014060448.1\|8705382_8707779_+\|molybdopterin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|239155

Protein	Function_ID	Function_description	E-value
NC_015957.1\|WP_050993831.1\|8692862_8693981_+\|site-specific-integrase	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	1.8432e-21
NC_015957.1\|WP_014060449.1\|8707815_8708802_-\|adenosine-deaminase	gnl\|CDD\|236480	PRK09358, PRK09358, adenosine deaminase; Provisional.	1.67304e-151
NC_015957.1\|WP_014060446.1\|8702388_8703750_-\|deoxyguanosinetriphosphate-triphosphohydrolase	gnl\|CDD\|235098	PRK03007, PRK03007, deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional.	0
NC_015957.1\|WP_150112948.1\|8686596_8687439_-\|toprim-domain-containing-protein	gnl\|CDD\|379044	pfam13155, Toprim_2, Toprim-like. This is a family or Toprim-like proteins.	0.00849038
NC_015957.1\|WP_106685999.1\|8696861_8697941_-\|RNA-polymerase-sigma-factor	gnl\|CDD\|235640	PRK05901, PRK05901, RNA polymerase sigma factor; Provisional.	9.80429e-163
NC_015957.1\|WP_014060445.1\|8700756_8702052_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|170080	PRK09754, PRK09754, phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional.	1.97076e-69
NC_015957.1\|WP_167543252.1\|8690616_8691573_-\|hypothetical-protein	gnl\|CDD\|377856	pfam07508, Recombinase, Recombinase. This domain is usually found associated with pfam00239 in putative integrases/recombinases of mobile genetic elements of diverse bacteria and phages.	8.64116e-09
NC_015957.1\|WP_078505518.1\|8692104_8692980_+\|hypothetical-protein	gnl\|CDD\|379665	pfam14659, Phage_int_SAM_3, Phage integrase, N-terminal SAM-like domain. This domain is found in a variety of phage integrase proteins.	1.01956e-06
NC_015957.1\|WP_123060297.1\|8690459_8690630_+\|hypothetical-protein	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	2.98129e-11
NC_015957.1\|WP_014060442.1\|8695073_8696660_+\|sugar-kinase	gnl\|CDD\|198375	cd07809, FGGY_D-XK_1, D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases. This subgroup is composed of D-xylulose kinases (XK, also known as xylulokinase; EC 2.7.1.17) from bacteria and eukaryota. They share high sequence similarity with Escherichia coli xylulokinase (EcXK), which catalyzes the rate-limiting step in the ATP-dependent phosphorylation of D-xylulose to produce D-xylulose 5-phosphate (X5P) and ADP. Some uncharacterized sequences are also included in this subfamily. EcXK exists as a dimer. Each monomer consists of two large domains separated by an open cleft that forms an active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. The presence of Mg2+ or Mn2+ might be required for catalytic activity. Members of this subgroup belong to the FGGY family of carbohydrate kinases.	2.24503e-110
NC_015957.1\|WP_014060452.1\|8709599_8710295_+\|DUF218-domain-containing-protein	gnl\|CDD\|225500	COG2949, SanA, Uncharacterized membrane protein [Function unknown].	4.18081e-57
NC_015957.1\|WP_014060439.1\|8689060_8690314_-\|IS256-family-transposase	gnl\|CDD\|307151	pfam00872, Transposase_mut, Transposase, Mutator family.	2.59266e-65
NC_015957.1\|WP_014060438.1\|8688380_8688950_-\|deaminase-reductase	gnl\|CDD\|223340	COG0262, FolA, Dihydrofolate reductase [Coenzyme metabolism].	2.05224e-11
NC_015957.1\|WP_014060444.1\|8698722_8700681_-\|DNA-primase	gnl\|CDD\|235551	PRK05667, dnaG, DNA primase; Validated.	0
NC_015957.1\|WP_014060448.1\|8705382_8707779_+\|molybdopterin-dependent-oxidoreductase	gnl\|CDD\|239155	cd02754, MopB_Nitrate-R-NapA-like, Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored tetraheme cytochrome. Members of the MopB_Nitrate-R-NapA CD belong to the molybdopterin_binding (MopB) superfamily of proteins.	0

>NC_015957.1|WP_050993831.1|8692862_8693981_+|site-specific-integrase
MELPPVTRPKPLVWTPERIEHWKRTGEKPGPVMVWTPELTGQFLDFVKDDWLYELWHSLIFLGPRRGEMAALPWTEVSTDALWLRISQQIVEVAYELYGEAPKADSVRTLSLSLESADNLVSFRAKQEQKRQMWGDAYVETGRVWTHENGEGLHPDWISRRFTRLVELSGLPPVRLHDLRHLAATLSLLAGTDIKVVQEKLGHSSRQITSDTYTSVLPEMMRAEAESVMAVVPFQVRTPLTIPERAWQGDIAVFFVHGARQSGDAWAVGAQTQPGSDLLGMITLSGRGQDDAANAAVKWIRDRCATNDLELVRVENFNDHNPEEQRAEFSLTRFTVARSQSPGLDDWALPTGLPSIAARTTRRSSKGRRETA
>NC_015957.1|WP_078505518.1|8692104_8692980_+|hypothetical-protein
MFSPSYYRRCQCKGPLKDEAGNPILDAEGAPKIGDIGLTCPKLGKGHGTWYFYFEAERGEGNKRARVRRGGFAKLDDAKAKAKELYDAATAGTDVLSDETCGDFFLRWIKAKKSLARTTRHGYEEHINLYLLPHLGHIKRRDLKVRHLDKMYDAIEKENSARILHRLRVDQLQKDRDDAHQTWVRTAGYAKREERRFTRRAFLDANAALREGKQGLRKVTSAATMHRTTTPSARRCPGASSASRRSPRTGHSSWSCRRSPGPSRSSGHPSASSTGSAPARSPARSWSGRRS
>NC_015957.1|WP_014060440.1|8691699_8691909_-|helix-turn-helix-domain-containing-protein
MGLEELLALPATVNVTTAGRALGIGRDKAYELIRSGQFPVRTLPLGGTIRVPTAELWKILGVNARAERE
>NC_015957.1|WP_167543252.1|8690616_8691573_-|hypothetical-protein
MAHERVRESEAAPLRQAASRRIQQQTYEAITTWMNAEGYRTTRGGRWRPSVLANVLDHPAIAGLAEDADGNLVDSGGPRIIQPEEFKAIRAVRRLNDPTYRRAEQREYLMTGELTDCGLCGGIFGASPANSGSRGYRCLPNRPQHPGGCGRVRISADPFETYVAEHVVAELAKPEVSALIGQAREEILAEAAKLRAQVKADKARQKELGESYARSPDLSLSAFRAADKQLTDQIRENAAQARFLEQVRHVPVGAVPDLVRWWRHAPLASKQGVLTLMLERVTVYPAAARGSRTVDGDRVQLTWRKWNPSQRDSAVTAG
>NC_015957.1|WP_123060297.1|8690459_8690630_+|hypothetical-protein
MYYCLGAPLARMEIQIALHTLLHRFPQLDLVVPPQQLQWRTSFRSRALKAVPVTLR
>NC_015957.1|WP_014060439.1|8689060_8690314_-|IS256-family-transposase
MLSVVNANGSTPNGSLIDEIVREGARRMLAAALEAEVNAYIAEVAEERDESGRRLVVRNGYHQPRKVTTAAGSVEVKAPRVNDKRVDEANGERRQFSSAILPPWCRKSPKVSEVLPLLYLHGLSSGDFVPALEQFLGSSAGLSPATVTRLTAQWQADHTAFQDRDLSATDYVYVWADGVHLRIRLEEAKAAVLVLMGVRADGTKELIAMSDGYRESSEARAGLLRDCARRGMRAPVLAVGDGALGFWNALSEVFPMTRHQRCWVHKTANCLDALPKSAQPTAKRAIQEIYNAEDKEHAARAVAAFAKQYGAKYPKVVRRITDDEDELLAFFDYPAEHWIHLRTTNPIESTFATVRLRTRVTKGAGSRAAALAMVFKLIESAQARWRAVNAPHLVALVRAGARFERGQLVERPEGRAA
>NC_015957.1|WP_014060438.1|8688380_8688950_-|deaminase-reductase
MRPLRYSINGTLDGCCHHEAGLPPDEESMRYWTAEMERADALLFGRVTYEMMESAWRKPATGTWPDWMDEWQIPFAETIDRAKKYVVSSTLSGVDWNADLVQGDLGQAVQRLKQEPGEGLWVGGVTLPLALAELGLIDEYEFLVQPVVAGHGPTLLAGLGERIQLELVDRHEFRSGAVALRYRPTRVTA
>NC_015957.1|WP_014060437.1|8687684_8688080_-|hypothetical-protein
MNISRILKTAVPVAAAVSLMAASPAVAADYTGCTSKACGSVYGYRYKAIPGWDTYEIWIDNMIVSDKVKDDGYFPGIRIVFNNSNGAQDTYVWGNDNGTSQQLGGKYMYDLKDVWFQVCHNGGPCTKLSRF
>NC_015957.1|WP_150112948.1|8686596_8687439_-|toprim-domain-containing-protein
MAEVGRPGNQSFPELAATWLPPEELRRLAAYKVLLAYDNNQAGQLAAASGDEAGIERRELGDAAKLVDTALGYLLGSEQKVTVEGAEHAEGEVPKPGATEAAGLQEWLRTWADKELLTLRIQQAERAAVLLGDSVYVLAWNPEKQRPTLRVYDPGFFFPQWDDEDADFPSRVHLAWELPEDREAGLKARVRRVTYELGSRFRGRREPGAAVPVEPWASVEDDVLPDGRGVVAGGHQAGADAGPAADGQGQFPGAAGRHGAGPAGSDDRLLAGHTHHEHDS
>NC_015957.1|WP_167543251.1|8686229_8686631_-|hypothetical-protein
MPVIHITNTIPDGGEHWGRSAIARVLQGLDELAATDSDASAASATTGTPIIGLAGARLPVDRATGKPEKLTVQAGAVWQLGETGRMDALDTSPQLAELRSRVEHLLDGIAANSRVTAAGLGTLDASRCPRGTR
>NC_015957.1|WP_014060441.1|8694778_8695048_+|hypothetical-protein
MRYRLTFITGMAVGYVLGTRAGHERYEQLRACAQKFARNPAVRNTAESAAQGGRLAAVRALDKVRPLREKIGQRDARAVGEDDWGTSNT
>NC_015957.1|WP_014060442.1|8695073_8696660_+|sugar-kinase
MGIAAGLDSSSESTRIVVCDTDTGAVIKQGYAPHPVGGSGDVDPQAWLMSLGEAAEGGLLEGVQAIGVSAQQHGLLALDAGGVLVRPALMGNDKRAQSAAADLTEALGGRTAWAQAVGAVPTASQPVAKLRWLARSEPDSAHRVAELMQPHDWLVWQLLGRPVRRTTDRGTASSSGYWSAANGSWRPDLVQLALGHQVRLPEVIGPADAAGHTPEGLLISAGTGETMAAAFGLGVGVGDAVISLGASGSVFSVHHEALADPTGTILSYADATGMHLPVVHTLNAVRTLRGTAELLGTDLDGLSALAMKSTPGSYGLVLLPYLEGERTPHLPHTAGTLTGLRRESMKPEHLARAAFEGMLCGLADALDVLRGRGVQVRRVFLLGPAADLQAVRAIAPALLGVQVVVPQPADYAALGAARQAAWALGVSHGTQSPHEPPRWPAAASQVFEPGEELPVGQAVRQQYVAVREQTHPGAFEPEAFEPGTVEPGTVEPGAQETVGHAAGGGYEAGGYETGGGHDHGASGGYGAM
>NC_015957.1|WP_106685999.1|8696861_8697941_-|RNA-polymerase-sigma-factor
MADVAADPDPDGAPEAESAEPAEPAEPAEPVEPVESVDTVVEPVEPIEPPARADTSGPSADLFRQYLREIGRIPLLSAVEEVELARRVEAGLFAEEKLGNTPDLDSQLAVDLDRLVVLGRVAKRRLIEANLRLVVSVAKRYIGRGLTMLDLVQEGNLGLIRAVEKFDYARGYKFSTYATWWIRQAMSRALADQARTIRVPVHVVELINRVVRVQRRMLQERGYEPTPEEVAAHLDLLPERVSEVLRLAQEPVSLHAPVGEEDDVALGDLIEDGDAASPVESAAFLLLREHLEAVLSTLGERERKVVQLRYGLADGRPRTLEEIGRIFGVTRERIRQIESKTLNKLRDHAFADQLRGYLD
>NC_015957.1|WP_014060444.1|8698722_8700681_-|DNA-primase
MAGRINDDDVKAVRAAVPIDAVVSEYLQLRNGGGGNLKGLCPFHDEKSPSFQVSPSKGLYYCFGCQEGGDTVDFVMKIDHLSFAETIERLASQAGITLRYEEGGYTPGRQQGERTRLVEAHKAAAQFYVEQLERPEAEIGRTFLAERGFDQAAAQHFGVGYSPAGWDHLVRYLRGRGFTDKELILSGLVQEGRRGPIDRFRGRLMWPIRDISGEVVGFGARKLRDDDNGPKYLNTPETPLYRKSQVLYGIDLAKKDIAKASRAVVVEGYTDVMACHLAGVTTAIATCGTAFGGDHIKILRRLLMDNSGAEVVFTFDGDAAGQKAALRAFEDDQKFAAETYIAITPGGMDPCELRLAEGDEAVRTLVETRTQLFEFAIRQILARHNLDTAVGRAAALEEAAPVVAGIKNGSIQHESAVHLAGLLGILDTQFVVRRVSQLARWARERGRGSGGEQRGRPGGVPAGDGPQYRHRREPEAQGDPGAPAPPRGPRLDLRSPAHLAERELLKCALQYPQLVSPTFDAFGADEFTAAPYARVRMAIAEAGGTAGADADYLVRVRDVAPDDTVRGLILELTVEPLSLPRRRQREIDRTYVGQWLAAVRLQAVDRRIGEVHAGVQRLGPYADAASLSAFQEELKALQVYREGLRVRGAEAL
>NC_015957.1|WP_014060445.1|8700756_8702052_-|FAD-dependent-oxidoreductase
MVDAHQTFVIVGGGLAGAKAAETLRAEGFTGRVILIGDERDHPYERPPLSKGFLTGSQERDSVFVHEPAWYAQADIELHLGLPAVHLDRAAKAVTLGDGTRVHYDRLLLATGAEPRRLDIPGTDLAGVHHLRRLAHAERLKGVLTTLGRDNGQLVIAGAGWIGLEVAAAARGYGAEVTIVEPEPTPLHPVLGPELGALFADLHSEHGVRFHFGARLTEITGQDGMVLAALTDDGEEHPAHSVLAAIGAAPRAALAEAAGLEVVDRAAGGGIAVDTSLRTSDPDIFAAGDVASAPLGFLEGTPARAALPQSARLRVEHWANALNGGPAAARAMLGQDVAYDRVPYFFSDQYDVGLEYSGYAPPGSYDQVLVRGDVGKRQFIAFWLNDGRLLAGMNVNVWDVTESIQRLIRGGHQLDTAALADPSVPLTSLLP
>NC_015957.1|WP_014060446.1|8702388_8703750_-|deoxyguanosinetriphosphate-triphosphohydrolase
MSRSAPPEPDPAPPTGAPEADTGHVPGYAPADLERWAPEPDKRPGRTAFQRDRARVLHSAALRRLAGKTQVVPATPAADPGPAGRALAYDATPRTRLTHSLECAQVGRELGAALGCDPDLVETACLAHDLGHPPFGHNGERVLNEIAEPCGGFEGNAQSLRLLARLEPKRFVPGPEAGEPVSVGLNLTRAALDAATKYPWPRGGHPYSPRSPKFGVYEDDLPIFAWYRQGAPEGRTTFEAQVMDWADDVAYSVHDVEDGLHAGHLDPASLLSEPERREVFAVAADRYAPGAEPGELAEALDRLLGQEWWPHRYAGSSVAQARLKDATSQLIGRFCLAAEGATRAAYGAGRFTRYHAELVVPRAARLECAVLKAVADRYVIQRPDQELVRADQRVVIAELGDALIARAPEGLDPQFRALFDAAGDDRGRLRAIVDQIASLTDTSARWLHARLTA
>NC_015957.1|WP_014060448.1|8705382_8707779_+|molybdopterin-dependent-oxidoreductase
MAHVPGEHSPDPAPDPAPVDTHCPYCSLQCGMTLRPVPPGGGSDEKPGGVEVIERTAFPVNRGALCGKGRTAPAVLSSRVRLTEPLVRRPDSGRLEPATWEEALDRIAEGLEAAGRAYGRDAVGVFGGGGLTNEKAYALGKFARVVLGTPQIDYNGRFCMSSAAAAHQRAFGLDRGLPFPLADVARTGCVVLVGSNLAETMPPALRYLTELKEAGGRLIVVDPRRTRTAEQADLHLAPRPGTDLALALGLLHLVVAEGRVDEEFVERRTSGWPEARAAAMAHWPELVERITGVPLPDLRKAVTMFCDAENSMVLTARGPEQQSKGTDTVGAWINLCLATGRAGRPLSGYGCLTGQGNGQGGREHGQKADQLPGYRKLTDPAARAHVAAVWGVEPDALPGPGRSAYELLDALGRDVRALLLMGSNPLVSAPRAAHVESRLRSLDFLAVADVVLSETAALADVVLPVAQWAEETGTMTNLEGRVILRRAALTPPPGVRTDLWVLSGLAARLGWEKGFPADAEEVFEELRRASAGGPADYSGITYRRIAEEDGVFWPCPERAEETARKSAAGTARKGAAGTGWESVEGASERAQRTGSAGAGADPERAWADPEGARPQGAHGADPGGAEADPEGGERPSPPSRHPGPHPGTPRLFLDRFATDDGRARFAPVSHRPAAEEPDAAYPVLLTTGRVLAQYQSGAQTRRVTELNEAAPGPYVQLHPLLAERLGAAEGVPIAVVSRRGRAVAPARISRDIRPDTVFMPFHWAGPGRANTVTNPALDPVSRMPEFKVCAVRLELAEG
>NC_015957.1|WP_014060449.1|8707815_8708802_-|adenosine-deaminase
MPPIPTAELHLHIEGTLEPDLAFALAERNGVELPYATQEELKAAYSFSDLQDFLNLYYALMTVLRTEDDFADLTNAYLARARAQGVRHAEIFFDPQAHTARGVEIDTVIRGITRALDAAPETYGITTRLIMCFLRDESAESALETFEAARPHLDRIAAVGLDSAEVGNPPSKFREVYALAREAGLKCVAHAGEEGPPAYVWEALDILGVDRVDHGVRCLEDEALVARLVADRTPLTVCPLSNVRLRVVDRLEDHPLPAMLDAGLLVTVNSDDPAYFGGYVGDNFTAVRDALGLDETTLRTLARNSFEAAFLDEGTRAAYLKEVEGWTR
>NC_015957.1|WP_086019653.1|8708971_8709286_+|hypothetical-protein
MPSLTPDALRAAVAQIVPSRLPELNEHLTSAATSAQRTSSVGPLRAFTAHWGTVVNIERWPQRAARFHACEDLAADPLADPEEARAAASEIGRILRAAGEEIGA
>NC_015957.1|WP_014060452.1|8709599_8710295_+|DUF218-domain-containing-protein
MLGWVRRRLPRTRRGWRRLVQGGVLVCVLALLPATWLRLSTDDRIRTVADVPSAPVGVVFGAGLWNGEPSPYLAHRLDAAVRLYKDGRVHALLVTGDNSRHDYDEPDAMRAYLVKRGVPDRRIVSDFAGFDTWDSCSRARRVFGVHKAVLVSQGFHVRRALALCGAAGIDAYGVAVAEPHDVTWYFGGTREVVAAGKAALDATFEPDPHFLGPRERGIERALAGRGSSGSR

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Crispr_ID: NC_015957_22

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015957_22

8975925-8976020

Orphan

Consensus_repeat	Method
CAACAGCCGGGTCCCTACGGACAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015957_22

>merge|NC_015957|22|8975925-8976020|CRISPRCasFinder
CAGCAGCCGGGTCCCTACGGACAGCCGCCGCAGCCGCCCCAGCAGGGTTACGGCTACCCCGGGCAGCCGCAGGGCCAGCCGGGCCCCTACGGACAG

>NC_015957|22|21|8975925-8976020|CRISPRCasFinder
CAGCAGCCGGGTCCCTACGGACAG	CCGCCGCAGCCGCCCCAGCAGGGTTACGGCTACCCCGGGCAGCCGCAG
GGCCAGCCGGGCCCCTACGGACAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_015957.1\|WP_014060709.1\|8988363_8989596_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|234945
NC_015957.1\|WP_014060708.1\|8987092_8988235_-\|serine/threonine-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272
NC_015957.1\|WP_014060704.1\|8980021_8980636_-\|ATP-dependent-Clp-protease-proteolytic-subunit	unknown	unknown	gnl\|CDD\|178955
NC_015957.1\|WP_014060698.1\|8972085_8974719_-\|valine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235582
NC_015957.1\|WP_014060699.1\|8974836_8975772_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223065
NC_015957.1\|WP_014060697.1\|8970400_8971861_-\|penicillin-binding-protein-2	unknown	unknown	gnl\|CDD\|223839
NC_015957.1\|WP_014060705.1\|8980915_8982358_-\|trigger-factor	unknown	unknown	gnl\|CDD\|234956
NC_015957.1\|WP_106686006.1\|8968815_8970330_-\|bifunctional-folylpolyglutamate-synthase/dihydrofolate-synthase	unknown	unknown	gnl\|CDD\|223362
NC_015957.1\|WP_014060707.1\|8983775_8984957_+\|acyltransferase-family-protein	unknown	unknown	gnl\|CDD\|226122
NC_015957.1\|WP_014060695.1\|8968460_8968814_-\|DUF4233-domain-containing-protein	unknown	unknown	gnl\|CDD\|379420
NC_015957.1\|WP_014060690.1\|8962615_8964760_-\|penicillin-binding-protein-2	unknown	unknown	gnl\|CDD\|274573
NC_015957.1\|WP_014060692.1\|8965537_8966482_-\|rod-shape-determining-protein-MreC	unknown	unknown	gnl\|CDD\|237560
NC_015957.1\|WP_014060706.1\|8982966_8983161_-\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_043241082.1\|8964820_8965531_-\|rod-shape-determining-protein-MreD	unknown	unknown	gnl\|CDD\|274574
NC_015957.1\|WP_014060703.1\|8979302_8979959_-\|ATP-dependent-Clp-protease-proteolytic-subunit	unknown	unknown	gnl\|CDD\|237133
NC_015957.1\|WP_014060693.1\|8966630_8967650_-\|rod-shape-determining-protein	unknown	unknown	gnl\|CDD\|237562
NC_015957.1\|WP_167543301.1\|8985016_8986147_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223650
NC_015957.1\|WP_014060694.1\|8967971_8968385_-\|nucleoside-diphosphate-kinase	unknown	unknown	gnl\|CDD\|179085
NC_015957.1\|WP_014060702.1\|8977833_8979120_-\|ATP-dependent-Clp-protease-ATP-binding-subunit-ClpX	unknown	unknown	gnl\|CDD\|235422
NC_015957.1\|WP_014060701.1\|8976885_8977728_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|370723

Protein	Function_ID	Function_description	E-value
NC_015957.1\|WP_014060709.1\|8988363_8989596_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|234945	PRK01346, PRK01346, enhanced intracellular survival protein Eis.	2.8811e-157
NC_015957.1\|WP_014060708.1\|8987092_8988235_-\|serine/threonine-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	5.36221e-36
NC_015957.1\|WP_014060704.1\|8980021_8980636_-\|ATP-dependent-Clp-protease-proteolytic-subunit	gnl\|CDD\|178955	PRK00277, clpP, ATP-dependent Clp protease proteolytic subunit; Reviewed.	5.36537e-119
NC_015957.1\|WP_014060698.1\|8972085_8974719_-\|valine--tRNA-ligase	gnl\|CDD\|235582	PRK05729, valS, valyl-tRNA synthetase; Reviewed.	0
NC_015957.1\|WP_014060699.1\|8974836_8975772_+\|hypothetical-protein	gnl\|CDD\|223065	PHA03378, PHA03378, EBNA-3B; Provisional.	3.92343e-06
NC_015957.1\|WP_014060697.1\|8970400_8971861_-\|penicillin-binding-protein-2	gnl\|CDD\|223839	COG0768, FtsI, Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane].	7.59042e-81
NC_015957.1\|WP_014060705.1\|8980915_8982358_-\|trigger-factor	gnl\|CDD\|234956	PRK01490, tig, trigger factor; Provisional.	1.45663e-153
NC_015957.1\|WP_106686006.1\|8968815_8970330_-\|bifunctional-folylpolyglutamate-synthase/dihydrofolate-synthase	gnl\|CDD\|223362	COG0285, FolC, Folylpolyglutamate synthase [Coenzyme metabolism].	7.84984e-142
NC_015957.1\|WP_014060707.1\|8983775_8984957_+\|acyltransferase-family-protein	gnl\|CDD\|226122	COG3594, NolL, Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism].	1.34826e-33
NC_015957.1\|WP_014060695.1\|8968460_8968814_-\|DUF4233-domain-containing-protein	gnl\|CDD\|379420	pfam14017, DUF4233, Protein of unknown function (DUF4233). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 122 and 147 amino acids in length. Proteins in this family are integral membrane proteins.	4.51122e-23
NC_015957.1\|WP_014060690.1\|8962615_8964760_-\|penicillin-binding-protein-2	gnl\|CDD\|274573	TIGR03423, pbp2_mrdA, penicillin-binding protein 2. Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	0
NC_015957.1\|WP_014060692.1\|8965537_8966482_-\|rod-shape-determining-protein-MreC	gnl\|CDD\|237560	PRK13922, PRK13922, rod shape-determining protein MreC; Provisional.	2.38223e-64
NC_015957.1\|WP_167543301.1\|8985016_8986147_-\|ABC-transporter-permease	gnl\|CDD\|223650	COG0577, SalY, ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms].	2.30939e-10
NC_015957.1\|WP_043241082.1\|8964820_8965531_-\|rod-shape-determining-protein-MreD	gnl\|CDD\|274574	TIGR03426, shape_MreD, rod shape-determining protein MreD. Members of this protein family are the MreD protein of bacterial cell shape determination. Most rod-shaped bacteria depend on MreB and RodA to achieve either a rod shape or some other non-spherical morphology such as coil or stalk formation. MreD is encoded in an operon with MreB, and often with RodA and PBP-2 as well. It is highly hydrophobic (therefore somewhat low-complexity) and highly divergent, and therefore sometimes tricky to discover by homology, but this model finds most examples. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	4.69213e-14
NC_015957.1\|WP_014060703.1\|8979302_8979959_-\|ATP-dependent-Clp-protease-proteolytic-subunit	gnl\|CDD\|237133	PRK12553, PRK12553, ATP-dependent Clp protease proteolytic subunit; Reviewed.	8.33863e-123
NC_015957.1\|WP_014060693.1\|8966630_8967650_-\|rod-shape-determining-protein	gnl\|CDD\|237562	PRK13927, PRK13927, rod shape-determining protein MreB; Provisional.	0
NC_015957.1\|WP_014060694.1\|8967971_8968385_-\|nucleoside-diphosphate-kinase	gnl\|CDD\|179085	PRK00668, ndk, mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated.	2.83506e-74
NC_015957.1\|WP_014060702.1\|8977833_8979120_-\|ATP-dependent-Clp-protease-ATP-binding-subunit-ClpX	gnl\|CDD\|235422	PRK05342, clpX, ATP-dependent Clp protease ATP-binding subunit ClpX.	0
NC_015957.1\|WP_014060701.1\|8976885_8977728_+\|hypothetical-protein	gnl\|CDD\|370723	pfam09849, DUF2076, Uncharacterized protein conserved in bacteria (DUF2076). This domain, found in various hypothetical prokaryotic proteins, has no known function. The domain, however, is found in various periplasmic ligand-binding sensor proteins.	2.66291e-05

>NC_015957.1|WP_014060699.1|8974836_8975772_+|hypothetical-protein
MSHQQPPPQPGPYGGQPGAYGAGRPPVPNPYAQTPGYGQQPQGGYGQPGPYGGTGGYGHPQPANPYGQPPQPPQPGPVPQQGPGYYGGPQAPPPQGPAAGGRGKGRKVALAVGAVVVVGALGAGAFMLFGGGSGGPYKLTTPKTVAADYERQGSGTDDSDLSAAGRKDLQQVPVVKDPHLVAADYQTSGKEMLKFTGVWGEVTDPARGADLALAVIVKTLQDNGTAQAKGSPQTFSPDGFDGDVLKCQSMKFTSDQGSMEAPACVWGDKDTLGVTVMADPAAAVLGGGMSLEDAAGLTAKVRKDARVEIGG
>NC_015957.1|WP_014060698.1|8972085_8974719_-|valine--tRNA-ligase
MTENSSQRPASGPNSHPELPTQYAPADVEGPLYERWVERGYFEADAKSDKEPYAIVIPPPNVTGSLHLGHAFEHTIIDALTRRKRMQGFETLWQPGMDHAGIATQNVVERELAKEGVSRHDLGREAFVERVWQWKGESGGQISGQMRRLGDGVAWNRERFTMDEGLSKAVQTIFKRLYEDELIYRAERIINWCPRCLTAISDIEVEYDDDDGELVSIRYGEGDTSIIVATTRAETMLGDTAVAVHPDDERYRHLVGTEIELPLTGRRIPIVADEHVDPEFGTGAVKVTPAHDPNDFEIGQRHGLPNLTVMDEHAVITAHGPFQGLDRLEARSAVVGALRAEGRIVAEKRPYTHSVGHCSRCKTTIEPRLSMQWWVKVGPLAKAAGDAVRDGRVKIHPEDMSKRYFDWVDNLHDWCISRQLWWGHRIPVWYGPNGEVVCVGPNEEPPSGEGWHQDSDVLDTWFSSGLWPFSTLGWPEQTESMEKFYPNSVLVTGYDILFFWVARMMMFGLYAMDGTPPFHTIALHGMVRDQFGKKMSKSFGNAVNPLDWMDTYGSDAVRFTLARGANPGVDVPIGEDWVQASRNFANKIWNATRFALMNGATVEGELPAPERLSATDRWILSRLNEVVAEVDAYYEDYQFAKLSDVLYHFAWDEVFDWYVELSKTTFAKGGAEADAARRVLGEVLDVTLRLLHPVVPFVTEKLWTSLTGQESVVIAEWPGDSGFRDEAAEREIENLQQVVTEVRRFRADQGLQPGQRVPAKLELSGTSLAAHEDAMRSLLRLQPAGEDFTATASLPVAGATVALDLSGAIDVEAERKRLAKDLAAAEKDKAQTTAKLSNEGFLAKAPDHVVEKIRTRQATAEADIARITAQLAALPKG
>NC_015957.1|WP_014060697.1|8970400_8971861_-|penicillin-binding-protein-2
MNQPLRRASIFSLLLVLALLAWATYVQLARGASLRDNSHNSRVAISQYAGPLGDILAGGKPITGSASTDGALKYKRTYTDGKLWAPVIGYASQSYGSTQLEALDRQVLDGSDSRLKNPLEAVTRERSKPGDVITTINPAVQKAAYEGLGNKTGAAVALDPTTGAVLGLASTPSYDPGSFAGSSTKDQKAWLALQKDKKQPMLNRALRQTYPPGSTFKVLVAAAALENGLYSSVDEPTKSPDPYRLPGTVTDMRNENRSAPCKNATIRTALEYSCNTVFAKMAVDLGQSKVSAQAEKLGFDDSKLDIPVRAAKSLYPSGMNDSQTALSGMGQFDVTATPLQMAMVSSAIANDGKLMTPYEVDRSTDGTASALDRNQAKTYGEAMSKHTASELQSAMRTVVDEGTGTNAKIPGVTVGGKTGTAQHGENNSANPYAWFISYADAGGGHKVAVAVAVEDSDAARADISGGGLAGPIAKSMMKAALADSGS
>NC_015957.1|WP_106686006.1|8968815_8970330_-|bifunctional-folylpolyglutamate-synthase/dihydrofolate-synthase
MVGVSEERPQNESDEFEEIVEAETDRDPDLAVIEAGSRTLRAQSGPPQGDGIPSRPADPEVDRALREVEGELAKRWPETKLDPSLVRIESLMDILGSPQRSYPSIHITGTNGKTSTARMVESLLGAFELRTGRYTSPHVQSITERISLDGAPISAERFIETYQDIQPYIEMVDAQQEHRLSFFEVLTGMAYAAFADAPVDIAVVEVGMGGSWDATNVVDAGVAVIMPISLDHTDRLGTTPEQIATEKAGIVKQDATVVLAQQPVEAASVVLKRAVEVDATVAREGMEFGVLSREVAVGGQLLTLRGLGGEYPDVFLPLHGAHQAHNAAMALAAVEAFFGVGSQHARTLDIDAIRSAFASVTSPGRMEVVRRSPTVVLDAAHNPAGARAAAEAVTESFDFSRLIGVVGASADKDVRGVLEAFEPIFAEVVVTRNSSHRSMDPDELAAIAVEVFGSDRVQVEPRLDDALEEAITLAEEEGEYAGAGVLVTGSVITVGEARLLLGRG
>NC_015957.1|WP_014060695.1|8968460_8968814_-|DUF4233-domain-containing-protein
MRTLCASTLIGEFFVIGFAGLVAMKTSGLSTGTVWTVSGIAMVLCVLLCGMLSRPGAVQIGWALQIGLVLSGFVVTTMFVLGVVFAALWWASVHFGRKVDEAKARFAAASAASPDTA
>NC_015957.1|WP_014060694.1|8967971_8968385_-|nucleoside-diphosphate-kinase
MSQRTLVLLKPDAVRRGLVGEILGRIEKKAGWTISALELRRLDREVLEQHYAEHVGKPFYEPLMEFMASAPSVALVVEGERVIEGVRALAGPTDPIAAAPGSIRGDFGTIVRENLIHASDSEESAEREIKIFFPGLA
>NC_015957.1|WP_014060693.1|8966630_8967650_-|rod-shape-determining-protein
MSFIGRDMAVDLGTANTLVYVRGRGIVLNEPSVVAINTNTGGILAVGAEAKKMIGRTPGNIVAVRPLKDGVIADFEITERMLRYFILKIHKRRYLARPRVVVCVPSGITGVERRAVIEASTQAGARQVHIIEEPMAAAIGSGLPVHEATGNMVVDIGGGTTEVAVISLGGIVTAQSIRVAGDELDNAIIQHIKKEYSLLLGERTAENIKITIGSAAESDEEEHTEIRGRDLVSGLPKTVVISAAEVRKAMEEPVNSIVDAVKTTLDKCPPELSGDVMDRGIVLTGGGALLRGLDERLRQETGMPIHIAEDPLDSVALGSGKCVEEFEALQQVLDAQPRR
>NC_015957.1|WP_014060692.1|8965537_8966482_-|rod-shape-determining-protein-MreC
MRDTRESRLLLVLLVAIAFALITVDIRGGEDSPLDGARQAAASVFGPVEDGVATAVDPVGNAVAAVRESGDRHDRVRRLEEENTKLKQKLGNDSRNRARSAELDKLLKTAGAGQYGIKGAQVIGIGAAQGFSWTVTLDIGSNDGVRRDMTVINGDGLVGRVTTVGSSTATVLLAIDPDFTVGTRMEGSGELGFATGRGDRSLHVQLLNGKARIKPGDRMVTFGSQADKPFVPGVPVGKVVRVDPTGGDLTRTLQVRPYVRFSKLDIVGVVVQPPRGNPRDTVLPPKPAKPKPTPTVTVTANPSATATSPAANRS
>NC_015957.1|WP_043241082.1|8964820_8965531_-|rod-shape-determining-protein-MreD
MHLNRIVLSTCLVVFALVVQICVLARLQLPGAVPDLLLLVVLGLALVYGHTGGALIGFAAGLLADLAPPADHAAGRYALVLCVIGYLAGLAKPESGQLRSATGPMLVVVAAAIGATLLYAGVGILVGDDAARQVGLGKLLFTAALYDLLLAPFTVPLIMGLARRSENDPMADSAGGGGESPSRWISTAGGVSTGRVGRMSRLKRPGRAARIGSQRGGLLARTGKNRTARIKGVKRL
>NC_015957.1|WP_014060690.1|8962615_8964760_-|penicillin-binding-protein-2
MSNIPETGRTSRVTIRLVGLQILVFSLLLTLGGRLWYLQIRNGDEYTAEAANNHVQQVVHPAVRGSILDARGVPLADNETRLVVSASRTELMKMPDDGKAALTRLADVLGMKPKDVMDKVRLCDAKTPQPCWNGSPYQPIPITDEASAKQALQIREREEDFPGISAEPTAVRRYAAPAGSNAAQVLGYLSPVTDEQVKEAEHTKSPLLRSDQVGSNGLERQYDSELRGKAGVTRYEVDNLGRVIGQRESQRARPGGNVVTSIDSRVQSVAEKELEQAMRDARKQHDRNTGTNYKADSGAVVVMEAKTGRVVAMASNPSYDPNAWVGGISGKDYKQLTGKKSNYPLLNRAIQGQAAPGSIFKVVPTTAAINAGYSFNGPYPCTSSFNIGSQVFKNFESENYGGISLGRALEVSCDTVFYHLAYEQWKKDGGNKPKKKPGDWFYRTAHQFGLGKETGIDLPNEVTGRVPDRQWKKDYWKANKDAWCKTGKKDGSYGQRIAYENCLEGMKMRAGDSVNYSIGQGDTLVTPIQMATIYSAISNGGTLYNPTVGKAIVSPDGKDVQEIKPESHGKLPMKGQTREKIDSALAGVATRGTAAWRFQGWPQDKIPMHAKTGTAEVYGKQTTSWFATYTKDYSIVMTISQGGTGSGASGPAVRKIYNALYGVDAKGGIDKKKALLPQPQANLPKISSDGSIEPQPLGKRFEAASRERRRGANS
>NC_015957.1|WP_014060701.1|8976885_8977728_+|hypothetical-protein
MSHNQPPPPGPYGGGPSPYGGAQPNPYSGGQQQPAEPNPYAQPQGYGYPQAPLPQGYGYPQQAGPYGQPPYPAPPAAGGGGNRTKIIAVTVAGLVVVGAIVTGAVVLSGGDDGPKSMKLVTPKTLDDGTYTLDKGTDDLDNEGTSVQGSMPEGATSVLAQYKRSDDDNSGLAFSGMYGEIRDPEAVRDEMFKGFAGGDGSPTVEEKRKRFQPEGADGPSVECEVVKVYDRIYAPACVWAEETDAAMVLDVNAGNTSASDADMESFAKVTAGIYQDTRKPA
>NC_015957.1|WP_014060702.1|8977833_8979120_-|ATP-dependent-Clp-protease-ATP-binding-subunit-ClpX
MARIGDGGDLLKCSFCGKSQKQVKKLIAGPGVYICDECIDLCNEIIEEELAETSEVRWEELPKPREIYEFLEGYVVGQEAAKKALSVAVYNHYKRVQAGENGGHSRDDGIELAKSNILLLGPTGSGKTLLAQTLARMLNVPFAIADATALTEAGYVGEDVENILLKLIQAADYDVKKAETGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTTASVPPQGGRKHPHQEFIQIDTTNVLFIVGGAFAGLEKIIESRAGAKGIGFGATIRSKREIEASDQFQEVMPEDLVKFGMIPEFIGRLPVITSVHNLDREALLQILVEPRNALVKQYMRLFELDGVELDFDHPALEAIADQAILRGTGARGLRAIIEEVLMSAMYEVPSRKDVARVVITEDVVHSNVNPTLVPRTRGTEPGERHEKSA
>NC_015957.1|WP_014060703.1|8979302_8979959_-|ATP-dependent-Clp-protease-proteolytic-subunit
MSNFPGSGLYNGPMAESRYVVPRFVERTSQGIREYDPYAKLFEERVIFLGVQIDDASANDVMAQLLCLESMDPDRDISVYINSPGGSFTALTAIYDTMEFVKPDIQTVCMGQAASAAAVLLAAGTPGKRMALPNARILIHQPYSETGRGQVSDLEIAANEILRMRSQLEEMLAKHSTTPIEKIRDDIERDKILTAEESLAYGLVDQIVSTRKTSVGLG
>NC_015957.1|WP_014060704.1|8980021_8980636_-|ATP-dependent-Clp-protease-proteolytic-subunit
MTNTMPSAAGEPTVGGLGDQVYNRLLGERIIFLGQQVDDDIANKITAQLLLLAADPDKDIYLYINSPGGSISAGMAIYDTMQYIQNDVVTIAMGLAASMGQFLLSAGTPGKRFALPNAEILIHQPSAGLAGSASDIKIHAERLLHTKKRMAELTSFHTGQTVEQIVRDSDRDRWFSAQEAKEYGLVDDVMTSASSVPGGGGTGA
>NC_015957.1|WP_014060705.1|8980915_8982358_-|trigger-factor
MKSAVENLNPTRVRLTVEVPFEELKPSLDAAYKKINQQVTVPGFRKGKIPARIIDQRFGRGAVLEEAVNEALPKFYTDAVNEGELNPLGQPEVDITELKDNELLTFTAEVDIRPTIEIPDYSGIEVTVDAVEVSDEDLDKSVEQLRERFATTSPVERAAAEGDIVVIDLEAKVEGEVLEDGVATGVTYTIGSGELLDGIDEAVTGLEAGGEATFASELKGGSAQGKEAEVSVKVSEVKARELPELDDDFAQLASEFDTLEELRADSRKRLERSKKFEQATQAQEKVLDALLELVEVPIPEKLLEEEINTRKHNLEHHQLGQMGLNLESYLQMQDKTAEEFDAELKEQAEKGIRTQFVLDELVNKEQLSVGQEELTEHLMRRAQSSGMSPDQFAQAVVEGGQVPMLVGEVARGKALAVVVEAAKVVDDKGETVDLDDEEDETGETVEATSEAVEAPAGAEAATEAAEEPAESQEKQDKAES
>NC_015957.1|WP_014060706.1|8982966_8983161_-|hypothetical-protein
MAISLSLVLLVGIILVIMIRNGRVKWGPALVAILFGFLLASSNVAPDIQKFLDSAAQAIADVNP
>NC_015957.1|WP_014060707.1|8983775_8984957_+|acyltransferase-family-protein
MTNSLRPHSYQRTPLPQEAAPTPPTPRAEEPGQQASTPPAPSVPAGQKPKQRDAFFDNAKYLAIVLVAMAHSWEPLTDSSRTAEALYMVVYTFHMPAFIVISGYFSRSFDMRPDRLKRLITGVAVPYVIFEIAYTLFKRWADDDPTYDFSLLDPWYLTWFLIALFVWRLSTPLWKLVRWPIPLSLAVATLAAVSPDIGDDLDMQRLLQFLPFFVLGLCMKPEHFQMVRHRSVRIASVPIFACALVFAYWAAPRMTSVWFYHRESVQELGAPPWTGPVMTLALFGCSVVLVSCFFAWVPRRHMWFTVLGAGTLYGYLLHGFLAKGSRFWGWFDNEWLHKPLGEIAVTVIAASVVTVLCTPPVQRAFRFAMEPKMAWAFRKDPAEQARSRTTTAA
>NC_015957.1|WP_167543301.1|8985016_8986147_-|ABC-transporter-permease
MIGLPLRAGPASAHLASANSRANARRLASAITPIVLAMAFASTLVFMHTSEDHAGDRQRRAGIVADQVISAPDGLPSGTAARAGSVRGVAASVGLLRAGVLVPVGSGDGRWLRTASTQGVSGSGRDLAAVQDLDVRKGRLDALGPGRVAVDALLAKAAHVRVGHRLALHLPDGTRISPTVVAIYGRGLGIAELTLPRTALAGHVTSSFDSDVLVRDADGADRKAVAAALGPLGEQVTDRDGYAAAQDEDRKLNAWANTVMAAVLGGFAAVAAVNTLVMTVLDRRRELGTLRLIGTTRRQVLGMVRWEALLVATAGIALGTAIAMATLAPMMRGLTGEDPYVPPLTYAGFAGAAVALGLAATALPARAALRRTTPKP
>NC_015957.1|WP_014060708.1|8987092_8988235_-|serine/threonine-protein-phosphatase
MTGGVDTPWARMRRALHRARTGMRKAGVDYFRGEGSDRLALTALLLGIPAIAGGTIAQPDWCSPSALVLPIVAGGLLLRPASLLALYAAAATALIVESAVLGPYTEEDASSRVTPGTILVVAAVGFFGLLIAQFRSRVGVPWRRGGTMLFDLRERIRVQSKLPGLPRGWHREMALRPAGGQSFSGDFVVAARTGGGRTLEVVLTDVSGKGMDAASRALLLSGAFGGLLGSLPPHGFLPAANGYLLRQDWDEGFATSIHLVLDLDSGDFELFSAGHLPALQLSAGTGKWEEKSADGPLLGVYDGAQFDSTKGTLRPGDVLMLFTDGLVETADRDISEGIDRLTGEADRYVGSGFHGAAWHLIETVAKDVNDDRALLLICRQ
>NC_015957.1|WP_014060709.1|8988363_8989596_+|GNAT-family-N-acetyltransferase
MRTELRVLDPSIWDDWYGKLVLAFGGVPEAPEESALWRELTECERSIGVWDGADIVGTAGLFSFRLSVPGGAIVPAAGVTMVSVQATHRRRGTLRSMMRRQLDDIRAAGDEPLAVLTASEPDIYGRFGYGAATQNACAEIDTTQVRLTVPEGTDDVRLRVVPPESAVEACEAVYARRVSARPGMLERRPGWERLPLLDPPGEREGASPLRCVLAESGGEVSGYARFAVKPDWDLAGPKGTVILRDLEALDPASYAALWRLLFELDLTSVIRTGSRPVDDPWQHLVSDIRRCAVRLRDSLYVRLVDVGTALERRTYATPVDAVLEVTDPFCPWNEGRWRLSGDAKGASCERTQDAPDLRLGVRELGAAYLGGVSLTALAGAGRVREIRQGALTEAATAFASPVAPWLPHGF

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Crispr_ID: NC_015957_23

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015957_23

9521974-9522073

Orphan

Consensus_repeat	Method
CTCGGGGACTCGGGGGCTCAGGG	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_015957_23

>merge|NC_015957|23|9521974-9522073|CRISPRCasFinder
CCCGGTGGACCGGAAGCTCAGGGTGGCACCTCAGGGACTCGGGGACTCGGGGGCTCAGGGGCTCAGGGGCTCGGGGGCTCGGGGGCTCGGGGGCTCGGGG

>NC_015957|23|22|9521974-9522073|CRISPRCasFinder
CCCGGTGGACCGGAAGCTCAGGG	TGGCACCTCAGGGA
CTCGGGGACTCGGGGGCTCAGGG	GCTCAGGGGCTCGGGGG
CTCGGGGGCTCGGGGGCTCGGGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_015957.1\|WP_043237243.1\|9529739_9530888_-\|4-hydroxyphenylpyruvate-dioxygenase	unknown	unknown	gnl\|CDD\|273528
NC_015957.1\|WP_014061062.1\|9527094_9528462_-\|FAD-binding-protein	unknown	unknown	gnl\|CDD\|273050
NC_015957.1\|WP_043237235.1\|9515525_9515864_-\|ATP-dependent-Clp-protease-adapter-ClpS	unknown	unknown	gnl\|CDD\|178809
NC_015957.1\|WP_043237246.1\|9531632_9532229_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|378968
NC_015957.1\|WP_078505883.1\|9518474_9520778_-\|M6-family-metalloprotease-domain-containing-protein	unknown	unknown	gnl\|CDD\|368494
NC_015957.1\|WP_014061052.1\|9515920_9517264_+\|nicotinate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|236426
NC_015957.1\|WP_014061048.1\|9512695_9513121_-\|M67-family-metallopeptidase	unknown	unknown	gnl\|CDD\|163701
NC_015957.1\|WP_014061049.1\|9513289_9514702_-\|amino-acid-permease	unknown	unknown	gnl\|CDD\|224038
NC_015957.1\|WP_014061056.1\|9521179_9521461_+\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014061057.1\|9521446_9521953_-\|RDD-family-protein	unknown	unknown	gnl\|CDD\|377640
NC_015957.1\|WP_014061059.1\|9522816_9524544_-\|DUF2510-domain-containing-protein	unknown	unknown	gnl\|CDD\|377640
NC_015957.1\|WP_014061054.1\|9518026_9518341_-\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_043237238.1\|9517335_9517920_+\|nicotinamidase	unknown	unknown	gnl\|CDD\|238493
NC_015957.1\|WP_014061050.1\|9514914_9515526_-\|DUF2017-domain-containing-protein	unknown	unknown	gnl\|CDD\|378185
NC_015957.1\|WP_014061063.1\|9528535_9529561_-\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014061067.1\|9532250_9532475_+\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014061058.1\|9522091_9522667_-\|RDD-family-protein	unknown	unknown	gnl\|CDD\|377640
NC_015957.1\|WP_014061061.1\|9525930_9526980_+\|NAD(P)-dependent-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|176186
NC_015957.1\|WP_014061065.1\|9531070_9531538_+\|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
NC_015957.1\|WP_050993843.1\|9524847_9525768_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|375319

Protein	Function_ID	Function_description	E-value
NC_015957.1\|WP_043237235.1\|9515525_9515864_-\|ATP-dependent-Clp-protease-adapter-ClpS	gnl\|CDD\|178809	PRK00033, clpS, ATP-dependent Clp protease adaptor protein ClpS; Reviewed.	5.11132e-39
NC_015957.1\|WP_043237246.1\|9531632_9532229_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|378968	pfam12840, HTH_20, Helix-turn-helix domain. This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.	4.2204e-12
NC_015957.1\|WP_078505883.1\|9518474_9520778_-\|M6-family-metalloprotease-domain-containing-protein	gnl\|CDD\|368494	pfam05547, Peptidase_M6, Immune inhibitor A peptidase M6. The insect pathogenic Gram-positive Bacillus thuringiensis secretes immune inhibitor A, a metallopeptidase, which specifically cleaves host antibacterial proteins. A homolog of immune inhibitor A, PrtV, has been identified in the Gram-negative human pathogen Vibrio cholerae.	0
NC_015957.1\|WP_014061052.1\|9515920_9517264_+\|nicotinate-phosphoribosyltransferase	gnl\|CDD\|236426	PRK09243, PRK09243, nicotinate phosphoribosyltransferase; Validated.	0
NC_015957.1\|WP_014061048.1\|9512695_9513121_-\|M67-family-metallopeptidase	gnl\|CDD\|163701	cd08070, MPN_like, Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding). This family contains archaeal and bacterial MPN (also known as Mov34, PAD-1, JAMM, JAB, MPN+)-like domains. These domains contain the signature JAB1/MPN/Mov34 metalloenzyme (JAMM) motif, EXnHS/THX7SXXD, which is involved in zinc ion coordination and provides the active site for isopeptidase activity for the release of ubiquitin from ubiquitinated proteins (thus having deubiquitinating (DUB) activity) that are tagged for degradation. The JAMM proteins likely hydrolyze ubiquitin conjugates in a manner similar to thermolysin, in which the zinc-polarized aqua ligand serves as the nucleophile, compared with the classical DUBs that do so with a cysteine residue in the active site.	3.03645e-39
NC_015957.1\|WP_014061049.1\|9513289_9514702_-\|amino-acid-permease	gnl\|CDD\|224038	COG1113, AnsP, Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism].	0
NC_015957.1\|WP_014061062.1\|9527094_9528462_-\|FAD-binding-protein	gnl\|CDD\|273050	TIGR00387, Glycolate_oxidase_subunit_glcD., glycolate oxidase, subunit GlcD. This protein, the glycolate oxidase GlcD subunit, is similar in sequence to that of several D-lactate dehydrogenases, including that of E. coli. The glycolate oxidase has been found to have some D-lactate dehydrogenase activity. [Energy metabolism, Other].	2.87993e-133
NC_015957.1\|WP_014061057.1\|9521446_9521953_-\|RDD-family-protein	gnl\|CDD\|377640	pfam06271, RDD, RDD family. This family of proteins contain three highly conserved amino acids: one arginine and two aspartates, hence the name of RDD family. This region contains two predicted transmembrane regions. The arginine occurs at the N-terminus of the first helix and the first aspartate occurs in the middle of this helix. The molecular function of this region is unknown. However this region may be involved in transport of an as yet unknown set of ligands (Bateman A pers. obs.).	5.131e-15
NC_015957.1\|WP_014061059.1\|9522816_9524544_-\|DUF2510-domain-containing-protein	gnl\|CDD\|377640	pfam06271, RDD, RDD family. This family of proteins contain three highly conserved amino acids: one arginine and two aspartates, hence the name of RDD family. This region contains two predicted transmembrane regions. The arginine occurs at the N-terminus of the first helix and the first aspartate occurs in the middle of this helix. The molecular function of this region is unknown. However this region may be involved in transport of an as yet unknown set of ligands (Bateman A pers. obs.).	5.17693e-24
NC_015957.1\|WP_014061065.1\|9531070_9531538_+\|Lrp/AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	4.00682e-28
NC_015957.1\|WP_043237238.1\|9517335_9517920_+\|nicotinamidase	gnl\|CDD\|238493	cd01011, nicotinamidase, Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is also called pyrazinamidase, because in converts the tuberculosis drug pyrazinamide (PZA) into its active form pyrazinoic acid (POA).	1.84456e-73
NC_015957.1\|WP_014061050.1\|9514914_9515526_-\|DUF2017-domain-containing-protein	gnl\|CDD\|378185	pfam09438, DUF2017, Domain of unknown function (DUF2017). This is an alpha-helical domain found in gene neighborhoods that contain genes encoding ubiquitin, cysteine synthases and JAB peptidases.	3.18298e-57
NC_015957.1\|WP_043237243.1\|9529739_9530888_-\|4-hydroxyphenylpyruvate-dioxygenase	gnl\|CDD\|273528	TIGR01263, 4-hydroxyphenylpyruvate_dioxygenase, 4-hydroxyphenylpyruvate dioxygenase. This protein oxidizes 4-hydroxyphenylpyruvate, a tyrosine and phenylalanine catabolite, to homogentisate. Homogentisate can undergo a further non-enzymatic oxidation and polymerization into brown pigments that protect some bacterial species from light. A similar process occurs spontaneously in blood and is hemolytic (see . In some bacterial species, this enzyme has been studied as a hemolysin. [Energy metabolism, Amino acids and amines].	0
NC_015957.1\|WP_014061058.1\|9522091_9522667_-\|RDD-family-protein	gnl\|CDD\|377640	pfam06271, RDD, RDD family. This family of proteins contain three highly conserved amino acids: one arginine and two aspartates, hence the name of RDD family. This region contains two predicted transmembrane regions. The arginine occurs at the N-terminus of the first helix and the first aspartate occurs in the middle of this helix. The molecular function of this region is unknown. However this region may be involved in transport of an as yet unknown set of ligands (Bateman A pers. obs.).	3.13077e-26
NC_015957.1\|WP_014061061.1\|9525930_9526980_+\|NAD(P)-dependent-alcohol-dehydrogenase	gnl\|CDD\|176186	cd05283, CAD1, Cinnamyl alcohol dehydrogenases (CAD). Cinnamyl alcohol dehydrogenases (CAD), members of the medium chain dehydrogenase/reductase family, reduce cinnamaldehydes to cinnamyl alcohols in the last step of monolignal metabolism in plant cells walls. CAD binds 2 zinc ions and is NADPH- dependent. CAD family members are also found in non-plant species, e.g. in yeast where they have an aldehyde reductase activity. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	0
NC_015957.1\|WP_050993843.1\|9524847_9525768_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|375319	pfam17765, MLTR_LBD, MmyB-like transcription regulator ligand binding domain. This domain is found in a family of actinobacterial transcription factors. The structure shows it has a PAS domain like fold and it is bound to Myristic acid.	7.94073e-65

>NC_015957.1|WP_014061057.1|9521446_9521953_-|RDD-family-protein
MAPDPLSSPPHAFPAGMPPLATPGQRFAARLIDIVVLGVIWTVALIATGALQYTMDHPGEQHIGKVTLALIITMALYFGYEGVMLARSGQTLGKRALRIRVAMLSDGDVPAGQGWVRAAVYVLPGMLIPLLVGTVFWLVNSASLLWDKPFQRCLHDKAARTVVVSAAH
>NC_015957.1|WP_014061056.1|9521179_9521461_+|hypothetical-protein
MPRPTPAQLAYGSATVVLSTFAMLLLSQTRSGLGIAVVTVVGLASGLLVAVTVPVARVSRPSRTVRTSSPAAGSGPADSAGARSRAHADSMRG
>NC_015957.1|WP_078505883.1|9518474_9520778_-|M6-family-metalloprotease-domain-containing-protein
MAQADAPSTRVERRDPAPAKTDVQHDLEGPYSKQQEAQRQEALRQVISGDTKATTRGASKVVKLGKGKYVELAREKTDKIFTILVEFGDKVDDTTMYDPDGDGPQPPVKKYGGEPGPAHNTIAEPDRANDNSTAWQKDYNREHFQDLYFSKDKKKESLKKYYEKQSSGRYSVDGEVSDWVKVDWNEARYGSNYCGDTNCANAWDLIRDGVNQWAKDQKAAGRTDAQIKADLAEYDQWDRYDYDADGNFNEPDGYIDHFQIVHAGEDESAGGGAEGENAIWAHRWYAYGTDAGNTGPGENKSGGTQIGDTGIWVGDYTMQPENGGLGVFAHEYGHDLGLPDEYDTTGKGESSVAYWSLMSAGSWLGTGKDAIGDLPGDMNAWDKLQLGWLDYAKAKAGKKSTHTLGVAEYNTKNKQALVVELPAKPVTTEVVAPAEGAKQWWSGMGDDLKNTLTRSVDLTGKSKAGLDLQGWWDIEENFDYLYTEVSTDGGANWTPIDGTADGKAIPRDAGDKPALTGTAGAYKKLSFPLDAYAGKKIELRFRYQTDGGVAQKGFAADAITLTADGAPVFSDGAEGDDNGWTGDGFSRIGASFSKDYPQYYIAENRQYVSYDTTLKTGPYNFGWASTRPDWVEHFPYQNGLLIWQWDTSQPDNNVGVHPGSGLILPIDAHATPEKWADGTLMRNRIQTYDSPFSRLPSDGFTLHNDGKAAKVKPKPGNPVFDDHKGMYWDKSNPTGGVKIADTNTRVKILKELPGGSTMTVQVGPSAS
>NC_015957.1|WP_014061054.1|9518026_9518341_-|hypothetical-protein
MANGGFTKLPGGSVVVALTLPSPLGEGGVRVLVHAMNRQRALTRLRNLGLRAVYLRGNMAPPTPDEVTAVLHHPDGLVWRTAPDRGGELWHPIAALLRPSAPAS
>NC_015957.1|WP_043237238.1|9517335_9517920_+|nicotinamidase
MHRALIVVDIQNDFCEGGSLAVTGGADVAAAITDLIGEATPGYRHIVATRDHHIAPGDHFSDNPDYEHTWPVHCVAGTEGVGFHPNFAPAVASGAIEAVFDKGAYQAAYSGFEGIDEHGTSLAQWLREREVTEVDVVGIATDHCVRATALDARSEGFATHVLLDLTAGVSPATTERALGELRAAGVELSGKPVV
>NC_015957.1|WP_014061052.1|9515920_9517264_+|nicotinate-phosphoribosyltransferase
MDTADLGLPVDVPSTALFTDRYELTMLQAALRAGTADRRSVFEVFTRRLPEGRRYGVVAGTGRVLDAVENFRFDSDVLDFLAQQRIVDEPTLTWLADYRFRGDIWGYPEGEVYFPGSPIMRVEGTFAEAVLLETVILSIFNHDSAVAAAASRMSTAAGGRPLIEMGARRTHELAAVAAARAAYVGGFATTSDLAAGFRYNIPTVGTSAHAFTLLHDSERDAFTAQVQAHGSGTTLLVDTYDVAEAVRTAVEVAGKDLGAVRIDSGDLLLLAHRVRQQLDELGAKNTRITVTSDLDEYAIASLAAAPVDAYGVGTQLVTGSGHPTCSMVYKLVARAGSDTPDSPDAPLLPVAKKSMGSKSSVGGRKWAARRVDEHGVAEAEVVGTGTAPEELAGHQLLVELVRGGEIVGREPLDAARDRHIAARAGLPLSATQLSRGEPVLPTEYLPA
>NC_015957.1|WP_043237235.1|9515525_9515864_-|ATP-dependent-Clp-protease-adapter-ClpS
MRRPVPGGSMGRVSVAPVEIERPETREAPMSVPEPDVPWVTVVHNDPVNLMSYVTYVFQSYFGYPKDKAHRLMLDVHHKGRAIVSSGSREEMERDVQAMHGYGLWATLQQER
>NC_015957.1|WP_014061050.1|9514914_9515526_-|DUF2017-domain-containing-protein
MSGRFEPLPGGGAALSLDEVEISILRSLAMQLAELIGPGDQPAEGGDPLDALFADGPSKPPADPALARLFPDAYRAPDQELGPREEKTAREASAEFRRFTENDLRARKRDDALTVVRDLDSLASGASAGAPGVLELAPEKARHWLTALNDLRLAIGARLEVTDEDDGGDLLRLPDSDPRKPMVMAYFWLGGLQETLVETLMPE
>NC_015957.1|WP_014061049.1|9513289_9514702_-|amino-acid-permease
MTSAAPEEGYERGLGSRQVQMIAIGGAIGVGLFMGAGANIAKAGPSIILMYALAGVVIFFIMRALGELLLYRPVSGSFAEYAREFLGPFFGFVTGWTYWLMWVVTGMAELTAAAIYINYWYPSIPQWVSALVFLVVLFGVNLISVKIFGEVEFWFSMVKVTAIIGMIVIGLGVLTLGFSDAGDTAAASNLWSHGGFFPHGIGDSLMTLQGVMFAYLAVELVGVTAGESEDPEKTLPKAINTLPWRIIIFYVGALVVLLAVVKWTEFSAGESPFVHAFSKIGIPFAAGIVNFVVLTAALSSCNSGMYSTGRMLRGLAANNEAPRAFGMLNSRKTPAIGITVSVLLMGIGVILNYVVPEKAFEYVTSVATAAGIWAWAMILLSHIKYRKAVTSGRLPASSFPAPGGAVFSWVALIFLIIVTGLIAYDKDARVCLYVGAGWAVLLVIGWFMLKSREGGRPGADAEAEPEYARK
>NC_015957.1|WP_014061048.1|9512695_9513121_-|M67-family-metallopeptidase
MLTITQALHDKIVAHARADHPDEACGVIAGPAGSGRPERFVPMLNAARSPTFYEFDSGDLLKLYREMDDRDEEPVVIYHSHTATEAYPSRTDISYANEPGAHYVLVSTAECGNDEGPAQFRSFRIVDGEVTEEEVEIVPGG
>NC_015957.1|WP_014061058.1|9522091_9522667_-|RDD-family-protein
MSTDQPPPGPDEPRDRDSSDPSAKYPRANGSPYEDHTAGTEPYAGMPPLAHLGRRLIARIIDALLVGIPVGLVLSAIVGGYDPVDGSARSTIVTLIYVLVYFVYEGLMLTRDGQTVGKKAMKIRVALLENGQPPAGQVGWVRAGVYTLPEIVPCCGFLFWLINVLWCTWDRPYRQCLHDKAAKTLVVSAVP
>NC_015957.1|WP_014061059.1|9522816_9524544_-|DUF2510-domain-containing-protein
MSAPTSGSADGSSIPGFYPDPSIPGYIRYWNGAAWVPGTSRPAPAVGEAMPAPPPGITHTQVISPAPDETGPMFLDEEPAPRPAEETGSALPELRRSAEMDIRGAGGPPEAAAGGMGAQPVPPGGVPASVDWNDPQRLYGTRPDAGSVWQADASRQGGFGGEQDHRVSWGSETDAPGDAQAGGGLPGGGQAGGGQWPGVPDPRSAGPGEGAGRDEGTLTMRAGGSGGTVDRSTQALPPVRRAPELPSADDGETPAPVSDGTMTIRAVGRGDGAAPTTGQGQGQGQGQGRNPASGRDDGTMAIRAIGRGGSRKGAEAAPPAQPPHQPQQPPQTHQPQQPPQPYQPQQPQQPFGGIPAQGGGPAWQQQGHQFAQQPGPAQGPPQAAPHGAPPGAPEGVIPWKPPVDNPFLLAAQAQGRPAPLGRRLAARLIDTVVLLGVVGAVAFPLWGKASDHIDEKVETAKQSGETVTVYFLDGATGGYLGIVLGLLLVLGIVLETLPTAKWGRTLGKKLSGVRVLDIEGHDTPSFGAALRRWLVYSVLGVLVIGVLNVLWCLFDRPWRQCWHDKAARTFIAAAD
>NC_015957.1|WP_050993843.1|9524847_9525768_+|helix-turn-helix-domain-containing-protein
MDRNTELSEFLRSRRARLSPGDAGVSVTNDSPRRVPGLRREELAQLAGVSTDYYTRLEQGRHLNVSETVLDAVARALQLDDTERAYLFELTRPRPRRTVRRRPPRPQRVRPGVHALLRTLDGISPAFVLGRRGDVLASNELARALIIDFEALPYHERNMARFMFLDEAARSLWTDWETVAAEMVASLRLEAGRHPEDPRLTELVGELTIKSADFRKWWADHNVREKTHGVKRYHHPVVGDMTLSYENVTVPGDPDQALCMYTVEPGSPSEAALRLLASWTAPPSARSSAPSSDARPSGGPSSDVSP
>NC_015957.1|WP_014061061.1|9525930_9526980_+|NAD(P)-dependent-alcohol-dehydrogenase
MTTSVTAYAAPAPKAPLEKTTVERRALREHDILIEIAYAGICHSDIHQAREEWGSAQFPMVPGHEIAGVVAEVGPGVTKYAVGDRVGVGCFVDSCRECANCLAGEEQFCLKGEVQTYNGTEYDGAPTYGGYSTHIVVDENYALRIPEGISLDIAAPLLCAGITLYSPLAHWNAGPGKKVAIVGLGGLGHMGVKIAHAMGAEVTVLSQTLRKKDDGLRLGADHFYATGDDSTFTELAGTFDLIVNTTSANLPLDGYLSLLKVDGTLVHVGAPENPSAFSQFSLIMGRRSMAGSKIGSIRETQEMLDFCAEHGLGAEIEVINGDQINEAYDRVVSSDVRYRFVIDIASLNA
>NC_015957.1|WP_014061062.1|9527094_9528462_-|FAD-binding-protein
MTDLIELLREGLPEEAVLTDPDVTGAYAYDMASFCEAGAPAVVVLPRTVEQVQHVCRTATALRVPVVPQGARTGLSGAANASEGCIVLSLVKMDRILEINPVDRIAVVEPGVINATLSRAVMEKGLYYPPDPSSWEQCTIGGNIGTASGGLCCVKYGVTAEYVLGLDVVLADGRLLRTGRRTAKGVAGYDLTRLFVGSEGSLGIVVGAVLALKPAPLEQLVLAAEFPSTASACDAICRIMERGHAPSLLELMDRTSVRAVNAMGNMGLPESTEALLMAAFDTPDPAPDLAAVAELCTAAGATEVVPAEDAAESDMLLQARRMTLPALEAVKGVTMIDDVCVPRSRLAEMIDGTAAIAEKHALTIGVVAHAGDGNTHPTVCFDPADPDESRRARESFDEIMALGLELGGTITGEHGVGVLKREWLARELGPVGVELQQGIKQVFDPLGLLNPGKLF
>NC_015957.1|WP_014061063.1|9528535_9529561_-|hypothetical-protein
MHTEKYTAGRLTRRRFTLGGGVAAAGALGAFAARAGAATVAGGRFDLSVPSTPLIREKTPHNATVLQSFAFDDVGGHLYTVQQMQGGIQLSGESAPVSGADRAAHGDLCLTKLSLAGAELGSMYLKGFGHGVAMGCEPVGATAYLWTESDANPDSGYGRAISRFKFADGTVLSSGSSSLVEHRPVAGSTSNQPAVDMLNRRLLLRYRLGGEARYRLMSLSGVSAGDYTAVYDDIPQTGVEDGEVFQGFTVLGDYAYQLTGTAYTDEGGANPPSGHGNTYVSCIDLRTGELVQRARTEAAYSLSYREPEGLAVQLSSPRRLCMGFASGAAGDRKVSVYYKAQ
>NC_015957.1|WP_043237243.1|9529739_9530888_-|4-hydroxyphenylpyruvate-dioxygenase
MTETTEMLQQGDARHADPFPVKGMDAVVFAVGNAKQAAHYYATAFGMKLVAYSGPENGSRETASYVLVSGSARFVFTSVIKPVSAWGRFLAEHVAEHGDGVIDLAVEVPDARAAYAYAVEHGAAGIEEPHELKDEHGTVVVASIRTYGDTRHTLIERTGYDGPYLPGFAEAEPIVDPPARRNFQAIDHCVGNVELGRMDEWVGFYNHVMGFTNMKEFVGDDIATEYSALMSKVVADGTRKVKFPLNEPAAGKKKSQIDEYLEFYGGPGVQHIALATNDIVATVRAMRAAGVRFLDTPDSYYETLGEWVGDTRVPVETLHELKILADRDEDGYLLQIFTKPVQDRPTVFFELIERHGSMGFGKGNFKALFEAIEREQEKRGNL
>NC_015957.1|WP_014061065.1|9531070_9531538_+|Lrp/AsnC-family-transcriptional-regulator
MGIDGLDARLIELLAEEPRIGVLEASRRLGVARGTAQARLDRLRAQGVIRGFGPDVDPAALGYPVTAFATLEIKQGQGQDVRAHLATVPEVLELHTTTGHGDMLCRLVARSNADLQRVIDLVVGFEGIVRASTAIVMENAVPLRIIPLVRQAALD
>NC_015957.1|WP_043237246.1|9531632_9532229_+|helix-turn-helix-transcriptional-regulator
MAENEEPAPDGVRVLDPRSLRGLAHPLRIRLLGALREYGPATASQLADRLGESSGATSYHLRQLAAHGFVKDDPERGKGRERWWKAAQRGVRVGTDRFLTSPDPAVRGAINTLLHEWATIHGQDLSTWFSTMHDWPSAWRSASDMSDFAMRLTPELASEMRDKVHEVIESYREKEVDRDTEGSAPYRVHLHAFPREED
>NC_015957.1|WP_014061067.1|9532250_9532475_+|hypothetical-protein
MYGDEIHLWLHRIRAERLQHEAHETYEAPRPHRRTRPARARALRARLGWTLVEVGLRLATPRLPQSGLTARFDH

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Crispr_ID: NC_015957_24

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015957_24

9612029-9612179

Orphan

Consensus_repeat	Method
CGGCACGGGACCCACCGGGACGCGCGGCACGGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015957_24

>merge|NC_015957|24|9612029-9612179|CRISPRCasFinder
GGGCACGGGAGCCGCCGGAGCACGCGGCACGGGACCCACCGGGACGCGCGGCACGGGCGCCGGGACCCGGAGCGGGGCGGGCGCCCAAGGCCACCGGGACGACGACGGCTGGGGCCCCGGCACGGGGCCCACCGGGACGCGCGGCACGGGC

>NC_015957|24|23|9612029-9612179|CRISPRCasFinder
GGGCACGGGAGCCGCCGGAGCACGCGGCACGGGA	CCCACCGGGACGCGCGGCACGGGCGCCGGGACCCGGAGCGGGGCGGGCGCCCAAGGCCACCGGGACGACGACGGCTGGGGCCC
CGGCACGGGGCCCACCGGGACGCGCGGCACGGGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015957.1\|WP_014061140.1\|9621510_9622554_+\|zinc-binding-dehydrogenase	unknown	unknown	gnl\|CDD\|176234
NC_015957.1\|WP_043237274.1\|9603858_9604548_-\|cell-division-ATP-binding-protein-FtsE	unknown	unknown	gnl\|CDD\|225438
NC_015957.1\|WP_014061123.1\|9599394_9600546_+\|FAD-dependent-monooxygenase	unknown	unknown	gnl\|CDD\|223727
NC_015957.1\|WP_014061141.1\|9622768_9623380_+\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_043237280.1\|9617341_9618715_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NC_015957.1\|WP_014061138.1\|9619657_9620227_-\|polyketide-cyclase/dehydrase	unknown	unknown	gnl\|CDD\|176871
NC_015957.1\|WP_014061137.1\|9618711_9619593_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_015957.1\|WP_014061132.1\|9608828_9610532_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_015957.1\|WP_014061124.1\|9601159_9601639_-\|SsrA-binding-protein-SmpB	unknown	unknown	gnl\|CDD\|376590
NC_015957.1\|WP_063644327.1\|9601657_9602869_-\|PDZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|272970
NC_015957.1\|WP_014061130.1\|9606124_9607237_-\|peptide-chain-release-factor-2	unknown	unknown	gnl\|CDD\|234799
NC_015957.1\|WP_014061142.1\|9623416_9623830_+\|Dabb-family-protein	unknown	unknown	gnl\|CDD\|214884
NC_015957.1\|WP_014061135.1\|9615958_9617317_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270451
NC_015957.1\|WP_014061143.1\|9623861_9624317_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|340413
NC_015957.1\|WP_014061126.1\|9602937_9603849_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|225088
NC_015957.1\|WP_014061131.1\|9607277_9608615_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_015957.1\|WP_014061129.1\|9605179_9605833_-\|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	gnl\|CDD\|236090
NC_015957.1\|WP_014061128.1\|9604877_9605072_+\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014061144.1\|9624485_9625400_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379262
NC_015957.1\|WP_014061139.1\|9620343_9621003_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379115

Protein	Function_ID	Function_description	E-value
NC_015957.1\|WP_014061140.1\|9621510_9622554_+\|zinc-binding-dehydrogenase	gnl\|CDD\|176234	cd08273, MDR8, Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family. This group is a member of the medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, but lacks the zinc-binding sites of the zinc-dependent alcohol dehydrogenases. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P)-binding Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	1.59928e-130
NC_015957.1\|WP_043237274.1\|9603858_9604548_-\|cell-division-ATP-binding-protein-FtsE	gnl\|CDD\|225438	COG2884, FtsE, Predicted ATPase involved in cell division [Cell division and chromosome partitioning].	1.7944e-124
NC_015957.1\|WP_014061123.1\|9599394_9600546_+\|FAD-dependent-monooxygenase	gnl\|CDD\|223727	COG0654, UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion].	1.59849e-24
NC_015957.1\|WP_043237280.1\|9617341_9618715_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	7.55836e-41
NC_015957.1\|WP_014061138.1\|9619657_9620227_-\|polyketide-cyclase/dehydrase	gnl\|CDD\|176871	cd08862, SRPBCC_Smu440-like, Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins. This family includes the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of Streptococcus mutans Smu.440 and related proteins. This domain belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. Streptococcus mutans is a dental pathogen, and the leading cause of dental caries. In this pathogen, the gene encoding Smu.440 is in the same operon as the gene encoding SMU.441, a member of the MarR protein family of transcriptional regulators involved in multiple antibiotic resistance. It has been suggested that SMU.440 is involved in polyketide-like antibiotic resistance.	1.84702e-26
NC_015957.1\|WP_014061137.1\|9618711_9619593_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	6.00499e-71
NC_015957.1\|WP_014061132.1\|9608828_9610532_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.37086e-100
NC_015957.1\|WP_014061124.1\|9601159_9601639_-\|SsrA-binding-protein-SmpB	gnl\|CDD\|376590	pfam01668, SmpB, SmpB protein.	8.153e-92
NC_015957.1\|WP_063644327.1\|9601657_9602869_-\|PDZ-domain-containing-protein	gnl\|CDD\|272970	TIGR00225, Tail-specific_protease, C-terminal peptidase (prc). A C-terminal peptidase with different substrates in different species including processing of D1 protein of the photosystem II reaction center in higher plants and cleavage of a peptide of 11 residues from the precursor form of penicillin-binding protein in E.coli E.coli and H influenza have the most distal branch of the tree and their proteins have an N-terminal 200 amino acids that show no homology to other proteins in the database. [Protein fate, Degradation of proteins, peptides, and glycopeptides, Protein fate, Protein modification and repair].	1.91528e-64
NC_015957.1\|WP_014061130.1\|9606124_9607237_-\|peptide-chain-release-factor-2	gnl\|CDD\|234799	PRK00578, prfB, peptide chain release factor 2; Validated.	0
NC_015957.1\|WP_014061142.1\|9623416_9623830_+\|Dabb-family-protein	gnl\|CDD\|214884	smart00886, Dabb, Stress responsive A/B Barrel Domain. The function of this domain is unknown, but it is upregulated in response to salt stress in Populus balsamifera (balsam poplar). It is also found at the C-terminus of a fructose 1,6-bisphosphate aldolase from Hydrogenophilus thermoluteolus.It is found in the pA01 plasmid, which encodes genes for molybdopterin uptake and degradation of plant alkaloid nicotine. The structure of one has been solved and the domain forms an alpha-beta barrel dimer. Although there is a clear duplication within the domain it is not obviously detectable in the sequence.	2.45665e-14
NC_015957.1\|WP_014061135.1\|9615958_9617317_+\|extracellular-solute-binding-protein	gnl\|CDD\|270451	cd14748, PBP2_UgpB, The periplasmic-binding component of ABC transport system specific for sn-glycerol-3-phosphate; possesses type 2 periplasmic binding fold. This group includes the periplasmic component of an ABC transport system specific for sn-glycerol-3-phosphate (G3P) and closely related proteins from archaea and bacteria. Under phophate starvation conditions, Escherichia coli can utilize G3P as phosphate source when exclusively imported by an ATP-binding cassette (ABC) transporter composed of the periplasmic binding protein, UgpB, the transmembrane subunits, UgpA and UgpE, and a homodimer of the nucleotide binding subunit, UgpC. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	8.9746e-30
NC_015957.1\|WP_014061143.1\|9623861_9624317_-\|ATP-binding-protein	gnl\|CDD\|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	2.03844e-17
NC_015957.1\|WP_014061126.1\|9602937_9603849_-\|ABC-transporter-permease	gnl\|CDD\|225088	COG2177, FtsX, Cell division protein [Cell division and chromosome partitioning].	9.44423e-63
NC_015957.1\|WP_014061131.1\|9607277_9608615_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	3.65465e-81
NC_015957.1\|WP_014061129.1\|9605179_9605833_-\|LPXTG-cell-wall-anchor-domain-containing-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	3.17985e-05
NC_015957.1\|WP_014061144.1\|9624485_9625400_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	3.66708e-07
NC_015957.1\|WP_014061139.1\|9620343_9621003_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|379115	pfam13305, WHG, WHG domain. This presumed domain is around 80 amino acids in length. It is found to the C-terminus of a DNA-binding helix-turn-helix domain. This domain may be involved in binding to an as yet unknown ligand that allows a transcriptional regulation response to that molecule. The domain is named WHG after three conserved residues near the C-terminus of the domain.	9.39929e-12

>NC_015957.1|WP_014061132.1|9608828_9610532_-|serine/threonine-protein-kinase
MRPVGSKYLLEEPLGRGATGTVWRASQREAAGAEAAVAGQPGETVAIKVLKEELANDADIVMRFLRERSVLLRLTHPNIVRTRDLVVEGDLLALVMDLIDGPDLHKYLRSNGPFTPVAASLLTAQIADALAASHADGVVHRDLKPANVLLAGTGEGQEMHPMLTDFGIARLADSPGLTRTQEFVGTPAYVAPESAEGRPQTSAVDIYGAGIMLYELVTGRPPFAGNTALEVLHRHLSEEPRRPSTVPEPLWTVIERCLRKRPEERPSAESLARALRVVAAGVGVHASAAQAEAALGVAALLAPDPAPAPVPDTAPADSADPTQVLPNAPGGTPSYDPAAATNVMPTTGANADPTQVLPTGSGPAGGADPTRAMPPVPPGQDDPHPWQNQLRAARDRNEQTQVQYLDPSQDPLRRRPHRAAPQQPYQQQQYQQPQQYQQPQQPQPPQRQRGRQQPPPYAQQQPQQYAPAPHHPQQPQPQRYAPPPQQPEPRGEPRQRGSSPNRMKIPGLGCLKGCLFVIVVLIVGSWLVWELTPLKDWIAEGQSYWDAVSGWAKDVQKWIEDLGGPSS
>NC_015957.1|WP_014061131.1|9607277_9608615_-|serine/threonine-protein-kinase
MSRKIGSRYTAHQLLGRGSAGTVWLGEGPEGPVAIKLLREDLSSDQELVERFVQERTVLLGLDHPRVVGVRDLVVDGNDLALVMDLIRGTDLRTRLDRERRLAPEAAVAIAVDVADALSAAHAAGVVHRDVKPENVLLDMGGPLGPGGAHPALLTDFGIARLVDEPTPIRAQPARDRASSQGRSPNPRSVIGTPDYLAPEIVEGLPPRASVDVYALATVLYEMLAGFTPFGGGHPGAILRRHVTETVAPLPGIPDELWQLLLQCLAKAPASRLRASELATRLRELLPSLAGYPPLDIDEPDEQQEGEQREGAEAKTPHRGVSVSAAGPAPSPSRRRGAVPLVPGAVPDSSRETHTSMRVPSADELAGGAHGTARAPRVHGQRRAGSARNPAVAGALRRRRLKVAAITLAALVAVGLGGWLVAGGDDGGDQPKGGEHSVSQDPGTP
>NC_015957.1|WP_014061130.1|9606124_9607237_-|peptide-chain-release-factor-2
MAVVDVSEELKSLSSTMGSIEAVLDLDKMRADIAVLEEQAAAPSLWDDPENAQKVTSKLSYLQGHLRRAEELRGRIDDLEVLFELAADEGDADARAEAESELEAVRKAVDEMEVRTLLSGEYDSREALVNVRAEAGGVDAADFAEQLQRMYLRWAERHGYKTQIYETSYAEEAGIKSTTFAVQIPYAYGTLSVEQGTHRLVRISPFDNQGRRQTSFAGVEVLPVVEQTDHIEIDESELRVDVYRSSGPGGQGVNTTDSAVRLTHIPTGIVVSCQNERSQIQNKASAMNVLQAKLLERRRQEEQAKMDALKGDGGNSWGNQMRSYVLHPYQMVKDLRTEFEVGNPQAVLDGEIDGFLEAGIRWRKQQEQGK
>NC_015957.1|WP_014061129.1|9605179_9605833_-|LPXTG-cell-wall-anchor-domain-containing-protein
MTKKTRLRVARIAAGAVIAAGASLTAAGAASAVGVDVGIGGVNVSANADEKGLDVGVGIGKPTDEPTDEPTSIPTGEPTDPPTDEPTDPPTDDPTQPPTGEPTDPPTDEPTQPPTSEPTGAPTDEPTASPSSPGQGGGSGGGDDSTCTVDLDSTNCDDNTGTDNVGSKPVEQGKAKEQLAETGSSETTFLLVGAATMIAGGIGFRFVPRLVNRNNVA
>NC_015957.1|WP_014061128.1|9604877_9605072_+|hypothetical-protein
MTYDRLVCANCASPVSEGRCPVCRASRERLQQDGIFGGLTPAALIALLVALITVAVLAHEMATA
>NC_015957.1|WP_043237274.1|9603858_9604548_-|cell-division-ATP-binding-protein-FtsE
MIRFDNVTKTYPKQNRPALRDVSLEIEKGEFVFLVGSSGSGKSTFLRLLLREERASHGAVHVLGKDLARLSNWKVPQMRRQLGTVFQDFRLLPNKTVGENVAFALEVIGKPRTAIRKTVPEVLDLVGLGGKDDRMPGELSGGEQQRVAIARAFVNRPMLLIADEPTGNLDPQTSVGIMKLLDRINRTGTTVVMATHDQQIVDQMRKRVIELEKGRLVRDQSRGVYGYQH
>NC_015957.1|WP_014061126.1|9602937_9603849_-|ABC-transporter-permease
MRAQFVLSEIGVGLRRNLTMTFAVIVSVALSLALFGGSLLMREQVSTMKGYWYDKVNVSIFLCNKNDKETAANCAKGAVTEAQKQEIESELKQMNIVESVHFETSEEAYKHYKEQFGDSPLADSLTPDQMQESFRIKLKDPERYDVISTAFAARPGVQEVQDQKALVDDLFNLLNGMNFAALGVMTLMLIVALMLIVNTVRVSAFSRRRETGIMRLVGASSFYIQMPFIMEAAIAGLLGAGFACVLLVSGQYFLVNNWLVDKIDVINFIGWDAVLAKLPLVLAIGLLMPAFAAFFALRKYLKV
>NC_015957.1|WP_063644327.1|9601657_9602869_-|PDZ-domain-containing-protein
MSGPCLFVQPRRIRRGAALTLVFVSVLATGAAVGSWGAEPGPRQDPQPVGMPARGYVGAVESDQVKAAAAAAQEDGKSGSKAAREVVSRSGDRWGAVYSAREYEGFRQKLDGAYVGVGISAHRDAHGRIAVERVEPGSPAQKAGIRADDRLRTVDGKNVTGRPVTEAVALLRGPADGSPGTRVELGLRRGGQKWTQELRRARLTTDPVTVDRLSGYDDHRPGAVRIKVDSFTKGTGERIRRAVRSIPRGDGILLDLRGNSGGLVSEAVTAASSLLDGGLVATYDVRGDQRVLDARPGGDTDSPLVVLVDGGTMSAAELLTGALQDRGRAVVVGSRTFGKGSVQMPSELPDGSVAELTVGHYRTPAGRNVDGEGIAPDLRVKADDGPSAEARARTVLSGLGGGS
>NC_015957.1|WP_014061124.1|9601159_9601639_-|SsrA-binding-protein-SmpB
MAKETGRKLIAQNKKARHDYHILDTYECGLVLTGTEVKSLRQGRASLVDGFAQLDGGEAWLHNVHIPEYSQGTWTNHSARRRRKLLLHRAEIDKLIGKTQETGHTLVPLALYFKDGRAKVEIALAKGKKEYDKRQTLRERQDRRESDRAISAVRRRQRA
>NC_015957.1|WP_014061123.1|9599394_9600546_+|FAD-dependent-monooxygenase
MTSSVSIIGAGLGGLTLARILHLHNIPATVYEAEKSAGVRTQGGQLDLHEEDGQLALEMAGLTEEYRSIIHRGGGARRVVDEQGRVVVDRPDDGSLARPETLRGDIRRILLASLPPGTVRWDKKLVSATPVGDGRHQVSFVDGSSAVSDVLVGADGVWSKVRALLSDERPVYSGMSYVDTCLHDVDTAHPRVAGLVGNGALYALVPGKGFLAHREAGDVVHTYVVLHRPVEWFDAIDFTDAPAAKARVAAEFDGWAPELLALITDGESAPVLRSIYELPDDHRWDRAPGVTLLGDAAHATVPGGDGANLAMLDGAELGTAIAAHPDDIERALTDYESGMFPRSHKAAAAAHRTIDFIFGANAPTGVISLFSEAARSPGSSEHR
>NC_015957.1|WP_014061135.1|9615958_9617317_+|extracellular-solute-binding-protein
MHVSLPAKRSTRAAVALLAAGALMLTAAGCGGDDGGTVSGGPPPNTVKLPSLKGQKLQVTAVWTGTEQENFTKVLKEFEKRTGAKVSFVPSGDDMAGFVGSKVAGGAPPDVAMVGQVGVMREFAQKGWAKPLGAEASAELAKNYAKGWQDLGSYEGKPYGVYFKTSNKSLLWYNTSAFDYAGAKVPKTWQEFLAQAQLISDSGTDAVAIGGQDGWTLTDWFENVYLSQAGAEKYDQLAQHKIKWTDPSVKKALETLAELWGTRGLVAGGRSGALQTAFPDSVTKAFGNKAEPDAGMVFEADFVAANVADAGAELDQDAKVFPFPAVGGKAPVVTGGDVGVALTNSKAAQALLTFLASPDAGTIWAQSGGFISANKNVKFSAYPNASMRKIAQALIAAGNDFRFDMSDQAPASFGGKPAQGEWKALQDFLKNPRNVEGIQRQLEADAAKAYKN
>NC_015957.1|WP_043237280.1|9617341_9618715_+|sugar-ABC-transporter-permease
MSTATADGAATPGRASSAPPAQRPGAKKRKSVMGTRPWLAAVFLLPALVLLGALVVYPIGYSVYRSFFDASGNGFVGLDNYQEMFSDDATKTAIKNNIIWLILAPTVSTALGLIFAVLTERVRWATAFKLVVFMPMAISMLAAGIIFRLVYEQDPDKGVANAMWVSVHDSFSESPPFPGAHPRPTAGLTEASGGSFTTRDTVRAGTPASLPLVAAKRGDISGAQDAKAAKAEPGKVTGTVWFDFTRGGGGEQGAIDKGEKAMAGLKIEAVKDGKVVARTTSAADGTYTLPAKAEGAQLRLPAWNFAQPYNGVDWLGPSIVTPAIIGAYVWIWAGFAMVLIAAGLAGVPRELMEAARMDGATEWQVFRRITVPMLAPVLSVVVVTLMINVMKIFDLVYIIAPGPSQDDANVLALQLFQSSFGTDVNQGLGSAIAVLLLLLVLPIMFINIRRIRRESRR
>NC_015957.1|WP_014061137.1|9618711_9619593_+|carbohydrate-ABC-transporter-permease
MTSADTVVQAKQSLVARIAARAGGGVMRVVLLLVGLLWLMPTAGLLLSSLRDPAEVDLSGWWKVFTDPGQLTFSGYDKILGNQQITDSLWTTLAITVPATLLVVAIGALAGYAFAWMDFPGRDWWFLIVVGLLVVPVQVALVPVAKLFGEIGIFQTTTGVVLFHTAFGLPFAIFLLRNFFAEIPRELLEAARLDGAGELRLFLRVVMPLGGPAIASLGIFQFLWVWNDMLVALIFADSGNPPITVALQQQVRQFGNNIDILGPGAFVSMIIPLAVFFAFQRQFVAGVMAGAVK
>NC_015957.1|WP_014061138.1|9619657_9620227_-|polyketide-cyclase/dehydrase
MLLKGIGVAALGTTVTLAVQPVAADEARPSARTYQDCQGVTVDKDAPVISRAGVLIKAPLTTVWRLHTDIDNWASWIPEITPARKTTPGPLRPGSSFEWSPQNMKVKSTVKTVRPLRCTAWGAPVNGITGVHLFTFKPVKGGVLATTEESWAGTPVEADIPGSQSSLDAGLKDWMQRLKDTAEARSGCH
>NC_015957.1|WP_014061139.1|9620343_9621003_+|TetR/AcrR-family-transcriptional-regulator
MEKTSAAGPAAPKRARTRNRRGEGSRLREDIVSAAAALLDETGDEHAITLRSVARKVGIAAPSIYPHFPDQPAIMLAVVQREFAELETLLRSAAEEAGDNPREQLHAVCRSYLAFAKSHPERYRTMFGGLWMPTLGDNSLTEEDLVSLDSTAIQVLVDVLTDCAAAGQCAISDPGLDAVTLWLSLHGLAHQRAVIRTFPWSEESIADSIIARITCLKDA
>NC_015957.1|WP_014061140.1|9621510_9622554_+|zinc-binding-dehydrogenase
MSTPVATRATEIVLPGAVEPSGLEVRSRDLPAPDTGQVLLRMDATGVSFAEQQMRRGKYYDQPPFPFVPGYDVVGTVTATGPGVDAGLTGRRFAAVTKVGAWASHLLIDAAELTPVPDGMDAATAETVVVNGITAWQMLHRMAKVRADGTVVVLGANGGVGSILVQLARHAGITVIGTASARHHASVRELGAIPVDYHDPDMYDQIREIAPDGVDAVFDHVGGPGVAQSWRLLRRGGTLVSYGTAATKNEEGSSQLPVLKLFGQLAAWNSLPNGRSAHFYNFWAGRRRRTEWQRRLTQDLTEVLRLVADGVLTPRIAAEIPLHDAASALALAESRTVIGKVVLVPGA
>NC_015957.1|WP_014061141.1|9622768_9623380_+|hypothetical-protein
MPLAITVPQVTDPSTAAAMRSPGEVDNRAAYIGFGLAYVFGHGSAALSKGTSPLLDLPAWLPMALLGAGLTAGTIQATRAALRAQRGAAGPDLLSGKLLGASWLIGFAALFLAITGLSSAVEMPDLQSMLWPTGSGLIVGLLYVSEGAARRNVLHYGLGVWLALTSTAALFLGTPGLYWVLTIAGGGAYAVATALERRRLGLH
>NC_015957.1|WP_014061142.1|9623416_9623830_+|Dabb-family-protein
MIYHGIRMKLREGITSQQIDEALDCLKDQGRAIPAVKSFIFGREYNSDFDWSAVFTLEDLDAYWEYLIHPVHVTSERIGFPLIEKFESFDISDTPHPELGAKIAELQKRHYEADPGLAELLSGLDSHTGSSALAHKS
>NC_015957.1|WP_014061143.1|9623861_9624317_-|ATP-binding-protein
MDNTVLKTITAPEPEPELRERTQQFPATPRGARLARRLAVRCMEEWGCPPASDASCTVALLVAELASNAVRHGRVPGRDFRLRLACAPSTRTIRIEVSDAREDRLPAVPSTLTADDESGRGLLLVDLLATRWGTTPRMPVGKTVWAECGAP
>NC_015957.1|WP_014061144.1|9624485_9625400_+|helix-turn-helix-transcriptional-regulator
MAALFGSRVRRLRTAAGLTQAELGERTHVVSTRITQIERASGAKPTFELARTLDTVLEADSLLVDMWPYVYREAFPDWSRAFMAYSERAVSIRQYAAHVVPGLLQSKDYARAVLSLDPLLSGEHQLGERVTARLGRQERLRSPDRPELWVVLDEAVLRRPIGGHSVMRAQLCRLLEAAGKRHITVQVLPFDQGGHEAMGGSLTVLTLPDGDEVAYKEGADFGQLVEEPSDVKRYSVTYDRLRAASLPPLMSLDMIRSVMEGNHRGASVPSRSERRRVAQEQLQQSGGWRLRGGGRRHTRRRPRP

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Crispr_ID: NC_015957_25

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015957_25

9909900-9909976

Orphan

Consensus_repeat	Method
GTGGACCAAGAGCAGCTACAGCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015957_25

>merge|NC_015957|25|9909900-9909976|CRISPRCasFinder
GTGGACCAAGAGCAGCTACAGCAGCAACGAAGGTCCGCAATGTGTCGAGGTGGCGTGGACGAAGAGCAGCTACAGCA

>NC_015957|25|24|9909900-9909976|CRISPRCasFinder
GTGGACCAAGAGCAGCTACAGCA	GCAACGAAGGTCCGCAATGTGTCGAGGTGGC
GTGGACGAAGAGCAGCTACAGCA

Protein	Signature genes	Signature genes Name	Protein_function
NC_015957.1\|WP_086019725.1\|9921071_9921695_+\|murein-L,D-transpeptidase	unknown	unknown	gnl\|CDD\|341130
NC_015957.1\|WP_014061362.1\|9909058_9909868_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|238045
NC_015957.1\|WP_014061364.1\|9910486_9911548_-\|LCP-family-protein	unknown	unknown	gnl\|CDD\|367673
NC_015957.1\|WP_014061372.1\|9919070_9920660_-\|methylmalonyl-CoA-mutase	unknown	unknown	gnl\|CDD\|239652
NC_015957.1\|WP_014061367.1\|9914545_9915970_-\|amidase	unknown	unknown	gnl\|CDD\|235686
NC_015957.1\|WP_014061366.1\|9913673_9914066_-\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_043237341.1\|9908504_9908951_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|340413
NC_015957.1\|WP_014061358.1\|9905780_9906032_-\|type-II-toxin-antitoxin-system-VapB-family-antitoxin	unknown	unknown	gnl\|CDD\|378324
NC_015957.1\|WP_014061354.1\|9902364_9903762_-\|gluconate-transporter	unknown	unknown	gnl\|CDD\|308194
NC_015957.1\|WP_014061369.1\|9916271_9917522_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|335313
NC_015957.1\|WP_014061370.1\|9917643_9918357_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225917
NC_015957.1\|WP_014061365.1\|9911565_9913677_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|224136
NC_015957.1\|WP_014061360.1\|9907675_9908512_+\|NAD(P)H-binding-protein	unknown	unknown	gnl\|CDD\|187578
NC_015957.1\|WP_014061353.1\|9901556_9902327_-\|glucose-1-dehydrogenase	unknown	unknown	gnl\|CDD\|236040
NC_015957.1\|WP_043237338.1\|9906675_9907566_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176127
NC_015957.1\|WP_014061356.1\|9904426_9905158_+\|FadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225097
NC_015957.1\|WP_014061368.1\|9916101_9916248_+\|SCO1431-family-membrane-protein	unknown	unknown	unknown
NC_015957.1\|WP_043237345.1\|9918777_9918993_-\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014061357.1\|9905361_9905778_-\|ribonuclease	unknown	unknown	gnl\|CDD\|350322
NC_015957.1\|WP_014061355.1\|9903781_9904294_-\|gluconokinase	unknown	unknown	gnl\|CDD\|225804

Protein	Function_ID	Function_description	E-value
NC_015957.1\|WP_086019725.1\|9921071_9921695_+\|murein-L,D-transpeptidase	gnl\|CDD\|341130	cd16913, YkuD_like, L,D-transpeptidases/carboxypeptidases similar to Bacillus YkuD. Members of the YkuD-like family of proteins are found in a range of bacteria. The best studied member Bacillus YkuD has been shown to act as an L,D-transpeptidase that gives rise to an alternative pathway for peptidoglycan cross-linking. Another member Helicobacter pylori Csd6 functions as an L,D-carboxypeptidase and regulates helical cell shape and motility. The conserved region contains a conserved histidine and cysteine, with the cysteine thought to be an active site residue.	2.80516e-22
NC_015957.1\|WP_014061362.1\|9909058_9909868_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	6.66278e-08
NC_015957.1\|WP_014061364.1\|9910486_9911548_-\|LCP-family-protein	gnl\|CDD\|367673	pfam03816, LytR_cpsA_psr, Cell envelope-related transcriptional attenuator domain.	2.40561e-61
NC_015957.1\|WP_014061367.1\|9914545_9915970_-\|amidase	gnl\|CDD\|235686	PRK06061, PRK06061, amidase; Provisional.	0
NC_015957.1\|WP_043237341.1\|9908504_9908951_-\|ATP-binding-protein	gnl\|CDD\|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	5.70719e-18
NC_015957.1\|WP_014061358.1\|9905780_9906032_-\|type-II-toxin-antitoxin-system-VapB-family-antitoxin	gnl\|CDD\|378324	pfam09957, VapB_antitoxin, Bacterial antitoxin of type II TA system, VapB. VapB is the antitoxin of a bacterial toxin-antitoxin gene pair. The cognate toxin is VapC, pfam05016. The family contains several related antitoxins from Cyanobacteria and Actinobacterial families. Antitoxins of this class carry an N-terminal ribbon-helix-helix domain, RHH, that is highly conserved across all type II bacterial antitoxins, which dimerizes with the RHH domain of a second VapB molecule. A hinge section follows the RHH, with an additional pair of flexible alpha helices at the C-terminus. This C-terminus is the Toxin-binding region of the dimer, and so is specific to the cognate toxin, whereas the RHH domain has the specific function of lying across the RNA-binding groove of the toxin dimer and inactivating the active-site - a more general function of all antitoxins.	4.80068e-10
NC_015957.1\|WP_014061354.1\|9902364_9903762_-\|gluconate-transporter	gnl\|CDD\|308194	pfam02447, GntP_permease, GntP family permease. This is a family of integral membrane permeases that are involved in gluconate uptake. E. coli contains several members of this family including GntU, a low affinity transporter, and GntT, a high affinity transporter.	8.81849e-135
NC_015957.1\|WP_014061369.1\|9916271_9917522_-\|hypothetical-protein	gnl\|CDD\|335313	pfam03403, PAF-AH_p_II, Platelet-activating factor acetylhydrolase, isoform II. Platelet-activating factor acetylhydrolase (PAF-AH) is a subfamily of phospholipases A2, responsible for inactivation of platelet-activating factor through cleavage of an acetyl group. Three known PAF-AHs are the brain heterotrimeric PAF-AH Ib, whose catalytic beta and gamma subunits are aligned in pfam02266, the extracellular, plasma PAF-AH (pPAF-AH), and the intracellular PAF-AH isoform II (PAF-AH II). This family aligns pPAF-AH and PAF-AH II, whose similarity was previously noted.	1.59524e-09
NC_015957.1\|WP_014061370.1\|9917643_9918357_+\|hypothetical-protein	gnl\|CDD\|225917	COG3382, COG3382, Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only].	1.52352e-60
NC_015957.1\|WP_014061365.1\|9911565_9913677_-\|glycosyltransferase	gnl\|CDD\|224136	COG1215, COG1215, Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane].	3.30561e-65
NC_015957.1\|WP_014061360.1\|9907675_9908512_+\|NAD(P)H-binding-protein	gnl\|CDD\|187578	cd05269, TMR_SDR_a, triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs. TMR is an atypical NADP-binding protein of the SDR family. It lacks the active site residues of the SDRs but has a glycine rich NAD(P)-binding motif that matches the extended SDRs. Proteins in this subgroup however, are more similar in length to the classical SDRs. TMR was identified as a reducer of triphenylmethane dyes, important environmental pollutants. This subgroup also includes Escherichia coli NADPH-dependent quinine oxidoreductase (QOR2), which catalyzes two-electron reduction of quinone; but is unlikely to play a major role in protecting against quinone cytotoxicity. Atypical SDRs are distinct from classical SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	4.36682e-49
NC_015957.1\|WP_014061353.1\|9901556_9902327_-\|glucose-1-dehydrogenase	gnl\|CDD\|236040	PRK07523, PRK07523, gluconate 5-dehydrogenase; Provisional.	2.02206e-121
NC_015957.1\|WP_043237338.1\|9906675_9907566_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176127	cd08436, PBP2_LTTR_like_3, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold. LysR-transcriptional regulators comprise the largest family of prokaryotic transcription factor. Homologs of some of LTTRs with similar domain organizations are also found in the archaea and eukaryotic organisms. The LTTRs are composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The genes controlled by the LTTRs have diverse functional roles including amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to a name a few. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	5.3075e-58
NC_015957.1\|WP_014061356.1\|9904426_9905158_+\|FadR-family-transcriptional-regulator	gnl\|CDD\|225097	COG2186, FadR, Transcriptional regulators [Transcription].	3.10209e-45
NC_015957.1\|WP_014061372.1\|9919070_9920660_-\|methylmalonyl-CoA-mutase	gnl\|CDD\|239652	cd03680, MM_CoA_mutase_ICM_like, Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM from S. cinnamonensis is comprised of a large and a small subunit. The holoenzyme appears to be an alpha2beta2 heterotetramer with up to 2 molecules of coenzyme B12 bound. The small subunit binds coenzyme B12. ICM catalyzes the reversible rearrangement of n-butyryl-CoA to isobutyryl-CoA, intermediates in fatty acid and valine catabolism, which in S. cinnamonensis can be converted to methylmalonyl-CoA and used in polyketide synthesis.	0
NC_015957.1\|WP_014061357.1\|9905361_9905778_-\|ribonuclease	gnl\|CDD\|350322	cd18755, PIN_MtVapC3_VapC21-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC3, VapC21 and related proteins. This subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC3 and VapC21 toxins. It belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is a PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include FitB toxin of the FitAB TA system, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	7.6812e-26
NC_015957.1\|WP_014061355.1\|9903781_9904294_-\|gluconokinase	gnl\|CDD\|225804	COG3265, GntK, Gluconate kinase [Carbohydrate transport and metabolism].	1.73152e-75

>NC_015957.1|WP_014061362.1|9909058_9909868_+|helix-turn-helix-domain-containing-protein
MEDEESGAVLRTVGRQIKLWREAAGLKQAELGAAIGYGEEQVSAVERARRIPSPEFLENADRVLGAGGKIAAMKKDVAEARYPKTVRDLAKLESEAVELGAYGNHNMDGLLQTEEHTRALFTMRRPLLSDDVIEQRVAARMARQEIFTSQPAPIFSFVQEEVTLRRPIGGKMVQRRQLEHLLELGRLRNVEIQVMPTERDDHAGMGGQLQLLKLKGGTTVGHVEVQRFTRLISDPREVQTLEIQYGIIRAQALTPRESLAFIEKLRGET
>NC_015957.1|WP_043237341.1|9908504_9908951_-|ATP-binding-protein
MSDVSQQITRTDTSVSHFTVLLSATRKGARLARLLGTERIRSWGLPHETGALIIAELAANAALHGRVPGRNFRLTLSVTGNTLRNEVRDPRVERLPTVRPAPEPEAPREGGHGLLLVEELADRWGVVPELIGKTVWAELDGTPCTGLT
>NC_015957.1|WP_014061360.1|9907675_9908512_+|NAD(P)H-binding-protein
MTILITGSRGGIGAGLLHRLSASGHDVRAASRAPEQADPPPGVTAVALDLADATTFAPALAGVTDVFLYAEPTRIERLLDAAVSAGVRRMVLLSSDSVNLPNAEHNALARHHLLVERALRAAPLTSTVLRPGGFATMTLGWAESIRADRPIEQAYPEARLDVIHPQDIIDVAESSLTTHALDGETISLGGPEVLSFRDQARILGDLLNREIELRAPAPEQAAAHLSAHVPAPFVAAVLDYWAQLSDRRIEASRTAERITGRPGRTFRQWVTENLASFR
>NC_015957.1|WP_043237338.1|9906675_9907566_-|LysR-family-transcriptional-regulator
MELRQLECFVAVAEESSFTRAAARLHIVQSAVSATIASLERELHTQLLWRTSRRVGLTESGYALLPKARVALDAAQDARAAVEEVSGTVRGALRVGTMSSLGPIDLPAMLGSFHREYPAVSVHLATAASSGGSPGLLTALTEGRLDLAFVSFPVGPPAGAHLRELTSTPLDLVVPAGHRLAGRSEAAMSELTGEAFIDFPPGYGNRAVTDRAFTAARLHRHVAIEITDITAGADFVRHGLGIALLPRGVVGPHDDLTTLPITGAELDWSISLAIPDNRTPSAAARAFEQFVDRHLK
>NC_015957.1|WP_014061358.1|9905780_9906032_-|type-II-toxin-antitoxin-system-VapB-family-antitoxin
MSATQIDIDDDALAEAMRLSGAKTKKEMVNIALREYAERRARTEARLRHLEQARQWDEEGFWLRHAAEKGAAGDSARTEQGAA
>NC_015957.1|WP_014061357.1|9905361_9905778_-|ribonuclease
MIRYLADSTAVWRLQRDRKLNDLWGHELDDGAIGSCAPQRTEFRQSARGLDEYDGMTEMFADLFPDVSVPKSAWKWIEVGQYRLAQRGQHQSLSVVDWLICATAAHHGLVVLHDDADFRAAARLLSDLAERNVFATPR
>NC_015957.1|WP_014061356.1|9904426_9905158_+|FadR-family-transcriptional-regulator
MDEQGPQGRGQRPRPQGLHDRLLESLGPAITGGDYPPGTVLRTDELERRYDVSRTVVREAVRVLESMHLVESRRRVGVTVRPTDEWDVFDPQIIRWRLAGPDRPRQLRSLTALRSAIEPAAAALAAEHATPEQCAELTEHALNMVATSRGQQLPAYLIHDVAFHRVILRASGNEMFARLGDVVAEVLTGRTQHRIMFTDPDPEAVTLHVRVAEAVRASDAEAAERYTREITVGALRELDILAP
>NC_015957.1|WP_014061355.1|9903781_9904294_-|gluconokinase
MHAPQVVVVMGVSGTGKTTVGPLLAEELGVPYAEADDFHPPANIAKMSAGTPLDDDDRRPWLDAIGAWAHDHAAGGGVVSCSALKRTYRDRLRSAAPGIVFLHLTGDRELIAERMKERKGHFFSGKLLDSQLATLEPLQPDEYGVAVDVGPEPELITERAAAELRRLEHQ
>NC_015957.1|WP_014061354.1|9902364_9903762_-|gluconate-transporter
MTRLSVEMLAADTVDPITSAGHAQLGIAVLVGIAVLVLLITQTKLHAFLSLTIGSLALGAVAGAPLDKVITSFSAGLGSTVAGVGVLIALGAILGKLLADSGGADQIVDTILAKASNRTMPWAMVLIAGIIGLPLFFEVGMVLMIPVVLLVAKRGNFSLMRIGIPALAGLSVMHGLVPPHPGPLAAIDAVHADLGITLALGVLIAVPTAIIAGPVFSRVADRWVHITPPDRLIPTRPSEELERRPGFGVTVLTVLLPVVLMLIKALVDIVVDDPENTVQRVADVIGAPLIALLAAVIVGMFTLGRAAGFTKDRISSTVEHSLAPIAGMLLIVAAGGGFKQTLIDIGVGKMIMDISQHWNVSALLLAWLIAVAIRLATGSATVATISAAGLMTPLAADMSSTHVALLVLSIGAGSLFFSHVNDAGFWLVKEYFGMSVGQTVRTWSVMESIISVVGLGFVLLLSLVI
>NC_015957.1|WP_014061353.1|9901556_9902327_-|glucose-1-dehydrogenase
MTTHPLFDIAGRTALVTGSSRGIGHALARGLVEAGCTVVLNGRDPHALEKAAAELGGADAGVHTAAFDVTDGPAVAAGIADVEERVGPLDILVNNAGTQNRAPLLEFTDDAWRQILDTNLTSAFLVGRETARRMTPRGHGKIVNICSLQSEVVRPGIAPYAATKGALKMLTKGMCADWGRYGIQVNGLGPGYIETELTRPLVEDEEFSSWVRGRTPAGRWGRTEDLVGALLYLASPAADFVSGQVLYVDGGMTSVL
>NC_015957.1|WP_014061364.1|9910486_9911548_-|LCP-family-protein
MSHDWPGDGNRYGYDSGYGEPAPRRRWPRRLRRTLIVLLAVALVGGASTYGWAWSKLNTDVDLGKVEHRPAKGKGTNYLVVGSDSRDGLSGRDKKTLHTGSAEGRRTDSMMVLHTGAHGATLMSLPRDSWVTIPPYTYPMTGKRPGPSKNKLNAAFSAGGPELLVRTIEHNTGLRIDHYAEIGFAGFVNVVNAVGGVHLCLNKPIKDKKSGANLKKGCQTLNGKQSLAFVRQRHQEAKGDLGRSQNQQKFLSALAKQAARPSQALVPWKVFPTVGAGLDTLIVDKGMDLRTLMSMFKAMQSVAGGHGHGNRLNVPVAGRGIATSKGSALKWDEGRARWLFERLRNDQPVGRRG
>NC_015957.1|WP_014061365.1|9911565_9913677_-|glycosyltransferase
MSPRHAHRPEPRGHWLLLIIVVSAVAAALVFEGWTTHEVASLSTRRPCTSPMPKAADTGKPVVRIGRGGTVETAGMPDRTVALTFDGGPDPVWTPRLLDLLRGHHAHATFFLSGAQAVRHPELVKRIRAEGHEIGSGAYTGSDLGSASSPRTRLELSLTQTALAGTAGINTKLVRLPLTTQADTMCGGEWTAARRAADQGYLLVAADRPLRQPERGVVRQYSQNDTGYAEANKLLRNRKIEKFATVSEGLGGPPVNTPVSTVGRLQGEALIQVQGIGHIFVQAMSWVLGIAGALALLRPALLVFFARAHVRRLQRFRPGAPWLREVDEPVTVLIPAYNEEAGIGSTVRSLLASTHWQLQIIVIDDGSTDRTADLATLIDDPRVLVVRQPNAGKAAALNTGLAHAHHDIVVMVDADTVFEPDAIHRLVQPLAHPAVGAVSGNTKVGNRRRLLGKWQHLEYVFGFNLERRMFEVLECMPTVPGAIGAFRRDALMGVGGVSEATLAEDTDLTMALWRAGWRVVYEETAIAWTEVPTSLRQLWRQRYRWCYGTLQSMWKHRRALREAGQAGRFARRALPYLFLFQVVLPLLAPIVDVFTLYGVLFADPVESIGVWLAFLVVQLLGAGYALRLDKERLTALWAMPLQLFVYRQLMYLVIIQSVVSALFGTRLRWHRIHRSGSAADRLTAGSAGSAGSAGSAERRLSSN
>NC_015957.1|WP_014061366.1|9913673_9914066_-|hypothetical-protein
MVTTVAEKRRRRRKQTGQIFVNASGGRRQLLALAALAVGCACLGYLLLLGTALSGVLWQADQEPPRTVERSTTGGTTGTTGTTGTTGTTGRTADTIGGDQAAGHWPSTYSYGAEVTEPLADAEPSRGGPG
>NC_015957.1|WP_014061367.1|9914545_9915970_-|amidase
MTSVIPKGLGEQIRALAGGEVTSHALVEQALGRIAETQPTLNAFRRIRAEAALREAAEADRRLAAGERLPLLGVPLAVKDDTDVAGEPTAFGCSGDFPAKVEDGEAVRRLRAAGAVIVGKTNTPELGQWPFTEGPAFGDTRNPWNPEYTPGGSSGGAAAAVAAGLVPAALGSDGAGSVRIPAAWTHLIGIKPQRGRISTWPDAESFNGITCHGPLARTVADAALLLDAVSGNCEGDLHCPEPVDVLSAVGRDPGRLRIALSFKPAFTGTPKRLDPLVRASVVRLAERLAALGHEVVAAEPRYGLVGFSFLPRATAGLFEWSGRVPDPLLLDIRTRHAARNGRLLGGAALRWARSYEEPLRRQVGAIFDRFDVVLSPTTATPPLRIGAMAALSGWQTDRAMIAACPYAWPWNVLGWPAMNVPAGFADPERTLPLGAQLLGPANSEPVLISLAAQLEADQRWYEHRPSVQGVFDGS
>NC_015957.1|WP_014061368.1|9916101_9916248_+|SCO1431-family-membrane-protein
MTDIAARRTGLHSRTGGPSDGEDHLLEHLLGWSLVVVLALLTTQLGLF
>NC_015957.1|WP_014061369.1|9916271_9917522_-|hypothetical-protein
MTTRTSDSGPRRRALLAATALAAVGVGMAQPKAVAAPAARRVRLTLPAPTGPYPVGTVSHRLVDQDRPDPWVASRPSRELMVSVRYPARDVERYPRAAQLLPGEAAGFDRLNNFGGVPQGRVDWAATRTFAHQGAPPARARRGAARPVVLYSPGVGDPRSLGTTLTDELASRGYVVICVDHTYDGSAVEFPDGRVETSRLPEEYVRAKQEGTVVELLRKTCAVRVADLRFVLDRLEALAPMPLDRSAIGAFGQSAGGFAALQAMHDDRRIAAAANLDGVLAYVEEDQDPGPLSTVAADGVDRPVLTMGKDGNDHHTVPSWGALWEHGTGPRLDLTLLGSAHATYTDATSMLPRIAARLGLPEKLVTDAIGTVAPERAVAVQRAYVPAFFDRELRHRDDGGLLDGPSARYPEVRFVD
>NC_015957.1|WP_014061370.1|9917643_9918357_+|hypothetical-protein
MTNDAAGWLDSAAIDPAVHALRPDYRALLITAEGLRPGPSDELSERLLADAEQTARERFGDGPVEEHPHLAAWREAFRAFGAKPQRTRPSAEALLRRAPAGLPRVDRLTDIYNAISVAHVIPLGGEDLDHYVGAARLVRAEGDETFETTAGGEPVAEHPAPGEVVWRDEAGVTCRRWNWRQCTRTRLTHATTRAMFVLDALGPMDDTALKAAGDQLMEALTDASPGLTLASRLVGAA
>NC_015957.1|WP_043237345.1|9918777_9918993_-|hypothetical-protein
MSSSPRRACPVCTREIAVVGGRFARHDPPGRRSALELISCPGSRRIAPLLTTPPKLFGEDEPPTPGQQSLF
>NC_015957.1|WP_014061372.1|9919070_9920660_-|methylmalonyl-CoA-mutase
MARESESGFPVEPVYGPGALSGWDPAGRLGEPGEYPFTRGVYPTMYTGRPWTMRQYAGFGTAAESNARYRQLIEHGTTGLSVAFDLPTQMGYDSDAPLAHGEVGKVGVAIDSVEDMRVLLGAIPLDRVSTSMTINAPAALLLLLYQLVAEEQGVAGSRLTGTIQNDILKEYIARGTYIFPPGPSLRLVADIFKYCKAELPKWNTISISGYHMAEAGASPAQEIAFTLADGIEYVRTAVAAGMDIDDFAPRLSFFFVSRTTLLEEVAKFRAARRIWARVMREEFGARDPKSQMLRFHTQTAGVQLTAQQPEVNLVRVAVQGLAAVLGGTQSLHTNAFDEAIALPTGNSARLALRTQQVLAYETDVTATVDPFAGSYAVESLTDAVEEAAVDLMRRVEDMGGAVAAIERNFQKEEIERSAYRIAQETDAGERVVVGVNRFQLEEEAPYEPLRVDPEIEARQRDRLARLRAERDRSAVSAALSSLRKAAESEPGTANVLYPMKDALAARATLGEVCDALREVWGTYKPVDAF
>NC_015957.1|WP_086019725.1|9921071_9921695_+|murein-L,D-transpeptidase
MIAVGTSGDRVRELQARLRALGLFNRNPTGYYGTITQASVSAYQRGHGLSVTGSVSRRTWTSLRSATKTPTRDQLHPPTTLPLAKPDPRCLTGRVLCISKTSRTLAWMVNGRVVSAMDVRFGSEYTPTREGLFQVNFKSRDHVSTIYHTPMPYAMFFSGGQAVHYSSDFAARGYSGASHGCVNVRDKKKIAALFGKVKAGDKVVVYK

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Crispr_ID: NC_015957_26

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015957_26

10106859-10106934

Orphan

Consensus_repeat	Method
GTGCAAGCGGCCGGAGGCCATCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015957_26

>merge|NC_015957|26|10106859-10106934|CRISPRCasFinder
GTGCAAGCGGCCGGAGGCCATCCTTGGGGGGGTGGCGGCCGGGCGACGGGCGGGCGCAAGCGGCCGGAGGCCATCC

>NC_015957|26|25|10106859-10106934|CRISPRCasFinder
GTGCAAGCGGCCGGAGGCCATCC	TTGGGGGGGTGGCGGCCGGGCGACGGGCGG
GCGCAAGCGGCCGGAGGCCATCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015957.1\|WP_014061507.1\|10098917_10099646_-\|copper-homeostasis-protein-CutC	unknown	unknown	gnl\|CDD\|225684
NC_015957.1\|WP_043241498.1\|10109591_10110539_+\|glucosyl-3-phosphoglycerate-synthase	unknown	unknown	gnl\|CDD\|237556
NC_015957.1\|WP_014061521.1\|10113753_10115037_-\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270452
NC_015957.1\|WP_014061509.1\|10100424_10101702_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|225371
NC_015957.1\|WP_043241501.1\|10113376_10113619_-\|DUF3263-domain-containing-protein	unknown	unknown	gnl\|CDD\|378688
NC_015957.1\|WP_014061518.1\|10110687_10112142_+\|trehalose-6-phosphate-synthase	unknown	unknown	gnl\|CDD\|340820
NC_015957.1\|WP_043237409.1\|10102890_10103829_+\|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224651
NC_015957.1\|WP_014061513.1\|10103922_10104894_+\|N-acetylmuramic-acid-6-phosphate-etherase	unknown	unknown	gnl\|CDD\|235467
NC_015957.1\|WP_086019660.1\|10096260_10098246_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|226482
NC_015957.1\|WP_043237411.1\|10112367_10113234_-\|trehalose-phosphatase	unknown	unknown	gnl\|CDD\|319767
NC_015957.1\|WP_014061510.1\|10102091_10102364_-\|DUF4031-domain-containing-protein	unknown	unknown	gnl\|CDD\|379076
NC_015957.1\|WP_014061508.1\|10099702_10100374_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226789
NC_015957.1\|WP_043237407.1\|10102363_10102729_-\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014061515.1\|10107661_10107940_-\|MoaD/ThiS-family-protein	unknown	unknown	gnl\|CDD\|340594
NC_015957.1\|WP_014061506.1\|10098254_10098674_-\|glyoxalase/bleomycin-resistance/dioxygenase-family-protein	unknown	unknown	gnl\|CDD\|319925
NC_015957.1\|WP_014061516.1\|10107936_10109238_-\|threonine-synthase	unknown	unknown	gnl\|CDD\|236065
NC_015957.1\|WP_043241504.1\|10115329_10116262_+\|ROK-family-protein	unknown	unknown	gnl\|CDD\|366120
NC_015957.1\|WP_014061523.1\|10116261_10117446_+\|N-acetylglucosamine-6-phosphate-deacetylase	unknown	unknown	gnl\|CDD\|238434
NC_015957.1\|WP_009716982.1\|10107045_10107252_-\|cold-shock-protein	unknown	unknown	gnl\|CDD\|224197
NC_015957.1\|WP_014061514.1\|10105051_10106677_-\|chaperonin-GroEL	unknown	unknown	gnl\|CDD\|234573

Protein	Function_ID	Function_description	E-value
NC_015957.1\|WP_014061507.1\|10098917_10099646_-\|copper-homeostasis-protein-CutC	gnl\|CDD\|225684	COG3142, CutC, Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism].	1.02854e-28
NC_015957.1\|WP_043241498.1\|10109591_10110539_+\|glucosyl-3-phosphoglycerate-synthase	gnl\|CDD\|237556	PRK13915, PRK13915, putative glucosyl-3-phosphoglycerate synthase; Provisional.	3.01994e-170
NC_015957.1\|WP_014061509.1\|10100424_10101702_+\|MFS-transporter	gnl\|CDD\|225371	COG2814, AraJ, Arabinose efflux permease [Carbohydrate transport and metabolism].	5.93769e-84
NC_015957.1\|WP_043241501.1\|10113376_10113619_-\|DUF3263-domain-containing-protein	gnl\|CDD\|378688	pfam11662, DUF3263, Protein of unknown function (DUF3263). This family of proteins with unknown function appears to be restricted to Actinobacteria.	1.97041e-31
NC_015957.1\|WP_014061518.1\|10110687_10112142_+\|trehalose-6-phosphate-synthase	gnl\|CDD\|340820	cd03788, GT20_TPS, trehalose-6-phosphate synthase. Trehalose-6-Phosphate Synthase (TPS, EC 2.4.1.15) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a nonreducing disaccharide present in a wide variety of organisms and may serve as a source of energy and carbon. It is characterized most notably in insect, plant, and microbial cells. Its production is often associated with a variety of stress conditions, including desiccation, dehydration, heat, cold, and oxidation. This family represents the catalytic domain of the TPS. Some members of this domain family coexist with a C-terminal trehalose phosphatase domain.	3.14953e-141
NC_015957.1\|WP_043237409.1\|10102890_10103829_+\|MurR/RpiR-family-transcriptional-regulator	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	1.63552e-69
NC_015957.1\|WP_014061513.1\|10103922_10104894_+\|N-acetylmuramic-acid-6-phosphate-etherase	gnl\|CDD\|235467	PRK05441, murQ, N-acetylmuramic acid-6-phosphate etherase; Reviewed.	9.90045e-157
NC_015957.1\|WP_086019660.1\|10096260_10098246_+\|AAA-family-ATPase	gnl\|CDD\|226482	COG3973, COG3973, Superfamily I DNA and RNA helicases [General function prediction only].	2.56308e-69
NC_015957.1\|WP_043237411.1\|10112367_10113234_-\|trehalose-phosphatase	gnl\|CDD\|319767	cd01627, HAD_TPP, trehalose-phosphate phosphatase similar to Escherichia coli trehalose-6-phosphate phosphatase OtsB and Saccharomyces cerevisiae trehalose-phosphatase TPS2. Trehalose biosynthesis in bacteria is known through three pathways - OtsAB, TreYZ and TreS. The OtsAB pathway, also known as the trehalose 6-phosphate synthase (TSP)/ Trehalose-6-phosphate phosphatase (TPP) pathway, is the most common route known to be involved in the stress response of Escherichia coli. It involves converting glucose-6-phosphate and UDP-glucose to form trehalose-6-phosphate (T6P), catalyzed by TPS, the product of the otsA gene, this step is followed by the dephosphorylation of T6P to yield trehalose and inorganic phosphate, catalyzed by a specific TPP, the product of otsB gene. This OtsAB (or TSP/TPP) pathway, is also the most common route known to be involved in the stress response of yeast In Saccharomyces cerevisiae, the corresponding enzymes, TPS1p and TPS2p, form a multimeric synthase complex together with additional regulatory subunits encoded by Tsl1 and Tps3. Trehalose is a common disaccharide accumulated by organisms as a reservation of carbohydrate and in response to unfavorable growth conditions. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.84827e-35
NC_015957.1\|WP_014061510.1\|10102091_10102364_-\|DUF4031-domain-containing-protein	gnl\|CDD\|379076	pfam13223, DUF4031, Protein of unknown function (DUF4031). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 91 and 130 amino acids in length. There is a conserved HYD sequence motif.	4.17458e-34
NC_015957.1\|WP_014061508.1\|10099702_10100374_+\|hypothetical-protein	gnl\|CDD\|226789	COG4339, COG4339, Uncharacterized protein conserved in bacteria [Function unknown].	4.02577e-40
NC_015957.1\|WP_014061521.1\|10113753_10115037_-\|extracellular-solute-binding-protein	gnl\|CDD\|270452	cd14749, PBP2_XBP1_like, The periplasmic-binding component of ABC transport systems specific for xylo-oligosaccharides; possesses type 2 periplasmic binding fold. This group represents the periplasmic component of an ABC transport system XBP1 that shows preference for xylo-oligosaccharides in the order of xylotriose > xylobiose > xylotetraose. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.70047e-52
NC_015957.1\|WP_014061515.1\|10107661_10107940_-\|MoaD/ThiS-family-protein	gnl\|CDD\|340594	cd17074, Ubl_CysO_like, ubiquitin-like (Ubl) domain found in Mycobacterium tuberculosis CysO and similar proteins. CysO, also termed 9.5 kDa culture filtrate antigen cfp10A, together with CysM (Cysteine synthase M), forms a protein complex CysM-CysO that represents a new cysteine biosynthetic pathway in Mycobacterium tuberculosis. The replacement of the acetyl group of O-acetylserine by CysO thiocarboxylate to generate a protein-bound cysteine is catalyzed by CysM in a pyridoxal 5?-phosphate (PLP)-dependent manner. The family also includes QbsE that functions as the sulfide donor for the biosynthesis of thioquinolobactin in Pseudomonas fluorescens. A JAMM motif protein QbsD catalyzes removal of the carboxy-terminal dipeptide from QbsE. Both CysO and QbsE are similar to prokaryotic sulfur carrier proteins such as ThiS and MoaD, containing the beta-grasp ubiquitin-like fold.	8.45025e-42
NC_015957.1\|WP_014061506.1\|10098254_10098674_-\|glyoxalase/bleomycin-resistance/dioxygenase-family-protein	gnl\|CDD\|319925	cd07264, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	2.84187e-18
NC_015957.1\|WP_014061516.1\|10107936_10109238_-\|threonine-synthase	gnl\|CDD\|236065	PRK07591, PRK07591, threonine synthase; Validated.	0
NC_015957.1\|WP_043241504.1\|10115329_10116262_+\|ROK-family-protein	gnl\|CDD\|366120	pfam00480, ROK, ROK family.	1.19075e-59
NC_015957.1\|WP_014061523.1\|10116261_10117446_+\|N-acetylglucosamine-6-phosphate-deacetylase	gnl\|CDD\|238434	cd00854, NagA, N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to amino-sugar-nucleotides, which is needed for cell wall peptidoglycan and teichoic acid biosynthesis. Deacetylation of N-acetylglucosamine is also important in lipopolysaccharide synthesis and cell wall recycling.	3.62314e-160
NC_015957.1\|WP_009716982.1\|10107045_10107252_-\|cold-shock-protein	gnl\|CDD\|224197	COG1278, CspC, Cold shock proteins [Transcription].	1.52185e-34
NC_015957.1\|WP_014061514.1\|10105051_10106677_-\|chaperonin-GroEL	gnl\|CDD\|234573	PRK00013, groEL, chaperonin GroEL; Reviewed.	0

>NC_015957.1|WP_014061514.1|10105051_10106677_-|chaperonin-GroEL
MAKIIAFDEEARRGLERGMNQLADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVKEGLRNVAAGANPMALKRGIEKAVEAVSAQLLEQAKDVETKEQIASTASISAADTQIGELIAEAMDKVGKEGVITVEESQTFGLELELTEGMRFDKGYISPYFATDMERMEASLDDPYILIVNSKISSVKDLLPLLEKVMQSGKPLLIIAEDVEGEALATLVVNKIRGTFKSVAVKAPGFGDRRKAMLGDIAILTGGTVISEEVGLKLENAGVDLLGRARKVTVTKDETTIVDGAGDTDQVQGRVNQIRAEIESSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGVALLQTVSIFEKLELEGDEATGAQAVRLALEAPLKQIAVNAGLEGGVVVEKVRNLTPGHGLNAATGEYVDLIAEGIIDPAKVTRSALQNAASIAALFLTTEAVIADKPEKAAPAGAPGGMPGGDMDF
>NC_015957.1|WP_014061513.1|10103922_10104894_+|N-acetylmuramic-acid-6-phosphate-etherase
MTSADFAADPTDSAADQDSTRLRAQLDTLTTEAFRPELAEIDRLETLEIARIMNAEDAGVPAAVALQLPRIAAAIDAIAARMSRGGRLLYTGAGTAGRLGVLDASECPPTFNTRPERVVGVIAGGPDAVVTSVEGAEDSAELAARDLDLLGIGPDDTVVGVSASGRTPYAVGAVEHGRRIGALTVGLSCNADSALAAAADHGIEIVVGPELLTGSTRLKAGTAQKLVLNMISTITMIRLGKTFGNLMVDVRASNDKLRARSRRIVFLATGASDQRIESALAATDGEVKNAILTILGEVDAPTAEKLLAEAHGHLRAALDAAKE
>NC_015957.1|WP_043237409.1|10102890_10103829_+|MurR/RpiR-family-transcriptional-regulator
MSSDLKETFMPPPQSAPTPPPPAALAAKVRTLGPSMTRSMQRVAEAVAGDPAGCAALTVTGLAERTGTSEATVVRTSRLLGYPGYRDLRIALAALAAHQAAGRAPAVTADIAVDDPIADVVTKLAREEQQCLADTAAVLDAGQVEAAVSALATARRIDVYGVGASSLVGQDLVQKLLRIGLIAHAHADPHLAVTNAVQLHSGDVAIAITHSGRTTDVIEPLRVAFERGATTVAITGRPDGEVAQYADLVLTTSTARESELRPAAMSSRTSQLLVVDCLFIGVAQRTYESAAPALSASYEALAHRHDPRPGHR
>NC_015957.1|WP_043237407.1|10102363_10102729_-|hypothetical-protein
MEPMKLEHALHAARALVLADLAAGEVARADIVSLVEDAIAHRRWWVEQWPEGIEYVAGLVAQDVQDALLERYGRWPLCPVCTQGGDLHALDVEPELGPNPHWVCGKTAVAVAPVGSLGTTL
>NC_015957.1|WP_014061510.1|10102091_10102364_-|DUF4031-domain-containing-protein
MAVLIDPPSWPGHGRLWSHLVSDVSYTELHAFAARIGAPRRGFDRDHYDLPSELYAKAVRAGAEEVGSKELLRRLKAAGLRRPQRAANAD
>NC_015957.1|WP_014061509.1|10100424_10101702_+|MFS-transporter
MPSSSPADSARSRMPLAVYVLGLSVFALGTSEFMLSGLLQPVARDMGVSIPTAGLLISAFAIGMVVGAPVLAAATLRLPRRTTLMALLAAFGLGQIAGALAPSYGVLFASRVVSAFACAGFWAVGAAVAVSLVPVNARAKAMAVMVGGLSIANIAGVPAGALLGQHAGWRAAFWAVAGLSALGLVGVVALVPRTEVPTGDDRPRLRAELRIYRDRQVWLALVATALSGGAVFCLFSYLGPLLTDVAGLDEGWVPTVLALFGVGALLGTVLGGRIADAHLFGTMLGGITASTVVLSALALTAHSAVAAVTLALLLGFTAFFTAPALNARMFNLANAAPTLAGATNTSAFNIGNTVGPWLGGLVIDLGWGYPAVAWTGAALAGTGVVTTVAAMRLHRAAGASRVIATSATYSPADAEAAPDPSRTTP
>NC_015957.1|WP_014061508.1|10099702_10100374_+|hypothetical-protein
MSAPAPARHPAHDALLTRWTDLLTSAREATAPPPAPYGEDLLTRWAEPQRRYHTTDHLLAVLDRVEELLPHVQAPDPAAIRLAAWFHDAVYLPDRSTNEERSARLAERALTEAAVPAPRTAETVRLVLVTRDHDPAEGDTNGEVLCDADLAVLAGSPAAYGAYAAAVREEYGFVPDDAFREGRANVLRHLLGLSRLFRTPEAHDRWEEPARRNMATELELLGS
>NC_015957.1|WP_014061507.1|10098917_10099646_-|copper-homeostasis-protein-CutC
MSRPILEVIALNPADAIAAQAGGADRLELVTDMAADGLTPSRETFAAVRSAVDLPVRVMLRAADGFAAGDPAAFDTLCEAAAALHSEGADEFVLGFLTDDGGVDLAAVTTLTEVVRAGGGVDESRWTFHRAIDRAADRDGLRKRLADIPGLDTYLTAGSARGVDDGLPTLAEEAARTGTPGYEPRIMAGGGLRLDHLSALRAAGIDAFHIGGAARPAGWAGPVDAAAVGRWRTALDAPVPVA
>NC_015957.1|WP_014061506.1|10098254_10098674_-|glyoxalase/bleomycin-resistance/dioxygenase-family-protein
MHFASIRIITEDVARITDFYERATGLTAKRYTDDFAELMTSSGTLALASTRTVRVLGEQAPRPAANQSVIVEFRVADVDGEYERLKEFDVEIVNEPTTQPWGNRSLLFKDPDGNLVNFFAPVTPDALKRYEQQTAEAKA
>NC_015957.1|WP_086019660.1|10096260_10098246_+|AAA-family-ATPase
MRADVEALDLRDVAANWVNAAALHHQVSERIKALADLADTPLFFGRLDYLHAPDAETAEGAEGERFYIGRRHVHDADGDPMVIDWRAPVSQPFYQASKTAPMDIALRRRFGYTGGELTAYEDERLSDPTEAEQTSKLLQSEIERPRVGPMRDIVATIQPEQDEIVRQGIGGTICVQGAPGTGKTAVGLHRVAYLLYAHRERLARSGTLVIGPNRSFLHYIEQVLPALGELQVAQATVEDLVTRPALGAEARGTDSADAARIKGDARLAEVLRRALRSYVTAPTEPCVVVRGSRRWRVPAYELEEMVEELLTRDIRYGAAREALPQRIAHTVLVRMEQAGEAPDDRVQDAVARNAAVKAAVKAVWPPVDPAKLVLRLLSDADFLAEHAEGVLDADEQKTVLWAKPGRGVKSAKWSPADLVLIDEAADLIERTPSLGHVVLDEAQDLSPMQYRAVGRRCSTGSATVLGDIAQGTTPWATASWEEALTHLGKDGAAIEELTQGFRVPREVIAYASRLLPAIAPGLSEATSIREAAGDFSVRAVDPAELDAAVIAACRDALTHEGSVGLIAADARVPALAEALDAAGLTHLSPGEETSAEARLTLVPATLAKGLEYDYVVLDEPAAVVDGEPDERTGLRRLYVSLTRAVSGLTVVHGAALPERLN
>NC_015957.1|WP_009716982.1|10107045_10107252_-|cold-shock-protein
MAQGTVKWFNAEKGYGFIAVDGGADVFVHYSAIQMDGYRTLEEGQRVEFEISQGQKGPQADMVRVAVG
>NC_015957.1|WP_014061515.1|10107661_10107940_-|MoaD/ThiS-family-protein
MSVNVRIPTILRTYTAGQAEVPAEGATLAEVLADLEKNHQGIAARVLDDTGKLRRFVNVYVNDDDVRFADGLATAIPDGAGISIIPAVAGGC
>NC_015957.1|WP_014061516.1|10107936_10109238_-|threonine-synthase
MAVQSVESSTTSSTSDASGAFGPAIALSCRECGERFDLGPIFACEVCFGPLEVAYELPAGDPEELRRRIEAGPNSIWRYAPLLPVPADVADQPSLHPGFTQLVKADNLARELGVTGELHIKDDSGNPTHSFKDRVVAIAVQAARTFGFTTLSCSSTGNLAGAVGAAAARAGFRSCVFIPHDLEAGKVVMAAVYGGELVGIEGTYDDVNRFCSELIGDPAGEGWGFVNVNLRPYYGEGSKTLAYEICEQLGWRLPDQIVIPIASGSQLTKIDKGLKELISIGLVEDKPYKIFGAQAEGCSPVSAAFKAGHDVVRPQKPQTIAKSLAIGNPADGPYVLDITRRTGGAVEDVNDEQIVDAIKLLARTEGIFAETAGGVTVGVTKKLIEDGLLDPSLTTVVLNTGDGLKTLDAVAPTTGPSAIIRPTLDSFREAGLA
>NC_015957.1|WP_043241498.1|10109591_10110539_+|glucosyl-3-phosphoglycerate-synthase
MLDEVERWLKHRSWSADDRPLNRLLDAKRGSATTLSVVLPALNEEATVGEIAATIRRELMGEAAPLVDELVVLDSGSTDRTAEVAAAAGATVVHRDSLLPGLPALPGKGEVLWRSLLATSGDIICFIDADLREFDPRFVSGIVGPLLTDPTLQLVKGMYDRPLGDVAGQGGRVTELVARPLLNLHWPQLAGFVQPLGGEYAARRTLLERLPFPVGYGVELGLLVDALHTVGLDALGQVDIGVRKHRHQDGLALGRMAAAIYRTAQLRLARGHLVRPRLTQFDRGETGFEPRTTAVDTEERPPMIEIPEYAERRAA
>NC_015957.1|WP_014061518.1|10110687_10112142_+|trehalose-6-phosphate-synthase
MAVPRTAPILVASNRGPVSYTLDEDGSLTARRGGGGLVSGLSAIGPDANAVWACAALGEGDREAARRAGDNHLNPGDTGGQQVRMLDIAPDVFAAAYNGIANSVLWFVHHLLYQTPVEPVFDAEFADQWAAYETYNAAFADALAEEAVDEAVVLVQDYHLALVPAMLRERRPDLRIGHFSHTPWAPPDYYRLLPDDVAAGVLRGILGGDRAAFLTERWAGAFADCCTAVLGAEIVRDGDGAATAVRFEGRETRLGVHGLGADADFLRQRSRQADVDERLTSLRAQIGPDRKSIVRVDRTELSKNIVRGLLAYRRLLETHPEWRERVVHVAFAYPSRQDLAVYRDYTERVRRLADEINAEYGTAGWTPVALHVKDDFARSLAAYRLADVALVNPIRDGMNLVAKEVPVVSERGCALVLSREAGAYAELGDDALVVNPYDVEATARALDEALRMSDGERADRTKRLAAAATALPPQAWFLAQLRAL
>NC_015957.1|WP_043237411.1|10112367_10113234_-|trehalose-phosphatase
MGSAMGSHPLPVPTTAAGREGLAALLERPGRAVVGLDFDGTLAEIVPDPDQARAHPGAVPALSRLAPRLRSVAVITGRPAEVAVRYGGFAGAEGLNGLVVLGLYGAERWDAASGAVQAPEPHPGVAAVQAELPAVLEEYGAAQGTWIEDKGRAVAVHTRRAEDPQATFELLRAPLHALAERHGLIVEPGRLVLELRPPGMDKGVALTEYVRRTDAEAVLYAGDDLGDLAAFAAVERLREEGVPGVLVCSGSSEVTELAERADLVVDGPAGVVELLSSLADAVSGANAS
>NC_015957.1|WP_043241501.1|10113376_10113619_-|DUF3263-domain-containing-protein
MEPGPGAGLSDRDVAVLAVERRGWPGPGAKERAIRERLGISPTRYYQLLNALLDDPRALEHDPVTVNRLRRVRDERRERR
>NC_015957.1|WP_014061521.1|10113753_10115037_-|extracellular-solute-binding-protein
MQRRRFLGLTTAGVAAVTTTPGLTACGSDSSGSDGDATLKVVAADYGDSTANGSQKYWNKLARAFEAKNSGIKVEVKVYSWTEVDRRVAEMVKNGQAPDIAQIGAYADYAAQGKLYRADEMLAIPTQAGFITSIAHAGEVRRVQYGVPFVASARLLFYNKKLFDQAGISSAPTSWDELKEAAVRLKADGVKIPYALPLGPEECQAETMMWMLSGGGGYTDTNGSYTIDSSANIETFEWLRDELVGADLTGPGSPARTNRQDAFDAFTRGEVGMLNGHPTLMQQASGHGISYGTAPLPGRRGKSPSTMGVADWLMAFKQNGHRTQIGKFLDFVYTEKNVLDFVTEYDLLPVTTAVEQTMLGDREYKRLWRFLDELESAEFYPADKTSWAEVSKLFKQKIGSTVAKGGDPTSVLGQIQREADAMENAGA
>NC_015957.1|WP_043241504.1|10115329_10116262_+|ROK-family-protein
MKHVIALDVGGTGMKAALIGADTTLLHEARRPTERERGPEAVVAAILDFAAELREIGERRFGGPPVAAGVGVPGVLDEDRGVAVFAANLGWSDVPLRALLTERLGGIPVALGHDVRMGGLAEGRIGAGEGARRFLFVSVGTGIAGAIGIDGRIDPGAHGSSGEIGHIVVRPGGPACGCGQSGCLETLASAAAVGRAWAGASGDPTADAADCAKAVRSGDPRAVAVWGEMVGALADGLVTGLTLLDPGVLIVGGGLAEAGETLFAPLRTAIEERLTFQQLPRIVPAALGDTAGCLGAGLLAWDRLSTEVTA
>NC_015957.1|WP_014061523.1|10116261_10117446_+|N-acetylglucosamine-6-phosphate-deacetylase
MVQRTVLTGARVVLPGGVVDNGRVTVEGTRITTTGPAADTASGHSEEAVEALDLPGRWIVPGFVDLHVHGGGGASFSAGTPEESLTAIRTHRLHGTTTMLASTVTGDLDDLARQAAVLSELVEQGELAGIHFEGPFISPHRCGAHQPSLLRAPDPADVRKLVDAARGTARMMTLAPELPGGLESVRLLADSGVLAAVGHTDSTYEATREAVEAGATVATHLFNAMPSLLHRAPGPIAALLEDERVTIELINDGTHLHPAMLELAFHRAGADRVAFITDAMGAAGMNDGRYPLGPMEVEVKDGVARISDGPTAGSIAGSTLTLDRAFQRAVTIDGLSVEQTVRALSATPARLLGIADRVGSLEVGKDADLVVLDDDFRLRGVMRRGSWVVHPEMS

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Crispr_ID: NC_015957_27

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015957_27

10503205-10503291

Orphan

Consensus_repeat	Method
CTCCGTACAGCGTGAGCAGATCCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015957_27

>merge|NC_015957|27|10503205-10503291|CRISPRCasFinder
CTCCGTACAGCGTGAGCAGATCCGCGGCACCCCGGCCCGCCCGGCACGCGCATCGTCGATGACTCCGTACAGCGTGAGCAGATCCGC

>NC_015957|27|26|10503205-10503291|CRISPRCasFinder
CTCCGTACAGCGTGAGCAGATCCGC	GGCACCCCGGCCCGCCCGGCACGCGCATCGTCGATGA
CTCCGTACAGCGTGAGCAGATCCGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015957.1\|WP_106686040.1\|10509617_10511381_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NC_015957.1\|WP_014061836.1\|10495141_10495306_+\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_050994134.1\|10508292_10509591_-\|bifunctional-glycosyltransferase-family-2/GtrA-family-protein	unknown	unknown	gnl\|CDD\|133031
NC_015957.1\|WP_014061851.1\|10513561_10514446_-\|amidohydrolase	unknown	unknown	gnl\|CDD\|368185
NC_015957.1\|WP_014061849.1\|10511640_10512378_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_015957.1\|WP_167543264.1\|10501946_10502114_-\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014061837.1\|10495467_10496301_+\|RNA-polymerase-sigma-factor-SigF	unknown	unknown	gnl\|CDD\|274373
NC_015957.1\|WP_014061844.1\|10503313_10504096_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|367243
NC_015957.1\|WP_014061840.1\|10498298_10498499_-\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_014061843.1\|10502112_10502964_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377274
NC_015957.1\|WP_043237467.1\|10516128_10516404_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236199
NC_015957.1\|WP_014061834.1\|10492989_10493874_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NC_015957.1\|WP_014061845.1\|10504175_10505699_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|184957
NC_015957.1\|WP_014061835.1\|10493878_10494904_-\|6-phosphofructokinase	unknown	unknown	gnl\|CDD\|274155
NC_015957.1\|WP_014061852.1\|10514752_10515379_+\|hypothetical-protein	unknown	unknown	unknown
NC_015957.1\|WP_078505918.1\|10505869_10508113_-\|glycosyltransferase-family-39-protein	unknown	unknown	gnl\|CDD\|379080
NC_015957.1\|WP_014061841.1\|10498701_10499190_+\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224759
NC_015957.1\|WP_014061838.1\|10496489_10497320_+\|RNA-polymerase-sigma-factor-SigF	unknown	unknown	gnl\|CDD\|274373
NC_015957.1\|WP_014061839.1\|10497386_10498229_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223029
NC_015957.1\|WP_014061850.1\|10512607_10513486_+\|LLM-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274681

Protein	Function_ID	Function_description	E-value
NC_015957.1\|WP_014061851.1\|10513561_10514446_-\|amidohydrolase	gnl\|CDD\|368185	pfam04909, Amidohydro_2, Amidohydrolase. These proteins are amidohydrolases that are related to pfam01979.	4.88786e-34
NC_015957.1\|WP_106686040.1\|10509617_10511381_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.90801e-32
NC_015957.1\|WP_014061843.1\|10502112_10502964_+\|hypothetical-protein	gnl\|CDD\|377274	pfam04264, YceI, YceI-like domain. E. coli YceI is a base-induced periplasmic protein. The recent structure of a member of this family shows that it binds to poly-isoprenoid. The structure consists of an extended, eight-stranded, antiparallel beta-barrel that resembles the lipocalin fold.	5.55684e-51
NC_015957.1\|WP_014061849.1\|10511640_10512378_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	3.08898e-85
NC_015957.1\|WP_014061850.1\|10512607_10513486_+\|LLM-class-F420-dependent-oxidoreductase	gnl\|CDD\|274681	TIGR03620, F420_MSMEG_4141, probable F420-dependent oxidoreductase, MSMEG_4141 family. Members of this protein family, related to F420-dependent oxidoreductases within the larger family of a bacterial luciferase (an FMN-dependent enzyme), occurs only within the small subset of species that synthesize F420. Most such proteins are from members of the Actinobacteria, but at least one species, Sphingomonas wittichii, belongs to the Alphaproteobacteria. [Unknown function, Enzymes of unknown specificity].	1.87484e-116
NC_015957.1\|WP_014061837.1\|10495467_10496301_+\|RNA-polymerase-sigma-factor-SigF	gnl\|CDD\|274373	TIGR02980, SigBFG, RNA polymerase sigma-70 factor, sigma-B/F/G subfamily. This group of similar sigma-70 factors includes clades found in Bacilli (including the sporulation factors SigF:TIGR02885 and SigG:TIGR02850 as well as SigB:TIGR02941), and the high GC gram positive bacteria (Actinobacteria) where a variable number of them are found depending on the lineage.	6.00388e-115
NC_015957.1\|WP_014061844.1\|10503313_10504096_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|367243	pfam02909, TetR_C, Tetracyclin repressor, C-terminal all-alpha domain.	1.2514e-14
NC_015957.1\|WP_014061841.1\|10498701_10499190_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224759	COG1846, MarR, Transcriptional regulators [Transcription].	3.67453e-12
NC_015957.1\|WP_043237467.1\|10516128_10516404_+\|hypothetical-protein	gnl\|CDD\|236199	PRK08244, PRK08244, monooxygenase.	0.00179345
NC_015957.1\|WP_014061834.1\|10492989_10493874_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	6.37384e-18
NC_015957.1\|WP_014061845.1\|10504175_10505699_-\|MFS-transporter	gnl\|CDD\|184957	PRK14995, PRK14995, SmvA family efflux MFS transporter.	1.01603e-66
NC_015957.1\|WP_014061835.1\|10493878_10494904_-\|6-phosphofructokinase	gnl\|CDD\|274155	TIGR02483, ATP-dependent_6-phosphofructokinase_1, phosphofructokinase. Members of this family that are characterized, save one, are phosphofructokinases dependent on pyrophosphate (EC 2.7.1.90) rather than ATP (EC 2.7.1.11). The exception is one of three phosphofructokinases from Streptomyces coelicolor. Family members are both bacterial and archaeal. [Energy metabolism, Glycolysis/gluconeogenesis].	2.01712e-176
NC_015957.1\|WP_078505918.1\|10505869_10508113_-\|glycosyltransferase-family-39-protein	gnl\|CDD\|379080	pfam13231, PMT_2, Dolichyl-phosphate-mannose-protein mannosyltransferase. This family contains members that are not captured by pfam02366.	4.4245e-33
NC_015957.1\|WP_050994134.1\|10508292_10509591_-\|bifunctional-glycosyltransferase-family-2/GtrA-family-protein	gnl\|CDD\|133031	cd04188, DPG_synthase, DPG_synthase is involved in protein N-linked glycosylation. UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.	1.10705e-74
NC_015957.1\|WP_014061838.1\|10496489_10497320_+\|RNA-polymerase-sigma-factor-SigF	gnl\|CDD\|274373	TIGR02980, SigBFG, RNA polymerase sigma-70 factor, sigma-B/F/G subfamily. This group of similar sigma-70 factors includes clades found in Bacilli (including the sporulation factors SigF:TIGR02885 and SigG:TIGR02850 as well as SigB:TIGR02941), and the high GC gram positive bacteria (Actinobacteria) where a variable number of them are found depending on the lineage.	1.60092e-125
NC_015957.1\|WP_014061839.1\|10497386_10498229_+\|hypothetical-protein	gnl\|CDD\|223029	PHA03264, PHA03264, envelope glycoprotein D; Provisional.	0.00354619

>NC_015957.1|WP_014061843.1|10502112_10502964_+|hypothetical-protein
MTTTGAGAGGGAGLRARIHTRDGWAVQHAVLTVTDMTGAQVLRAQANGDGAVRTDEPLSPGPYTIIATAVGYAPVASTAIVTASGRADVGTVVLARQGGVELPPPGVWTLDPAHSTVAAVAQHLGISSVHGRFTEFGGRIEVGEDIEKSRVEAVIQAASIDTGNSMRDGHLKSPDFLNVEAFPQLTYRSTHLSAAGADRWTVHGELSMHGVVRDVDLDLTYLGTGPDPWGGVRAAFRAIAELRREDFAMNYNQVVAAGIAAIGTTLRVELDIQAVQGEELPTA
>NC_015957.1|WP_167543264.1|10501946_10502114_-|hypothetical-protein
MPRFAPARVSLVLLVLLVLLVVLVLLVVFVVLVELVVLGAFAGYVVLVRRIRAAV
>NC_015957.1|WP_014061841.1|10498701_10499190_+|winged-helix-turn-helix-transcriptional-regulator
MATQRHYEELARQLSAIGTVKRGLGRVLPADCPSGAAIVLMLLDRYGEMRMSKLAELLDIDMSVTSRHVAHVADRGWVDRKADPLDRRSRLLTINASGQTLLGQVSERYTDALANCLSDWSDEDVDHLNELLDRLRRSFGDTRSRALPHQAETSITRTPSQR
>NC_015957.1|WP_014061840.1|10498298_10498499_-|hypothetical-protein
MANNPQSPNGNQDPSGSTQMFRAFVDEGTRQPQASTGSSGGSRVGLIVGVIAAVVIVAAVAWLALG
>NC_015957.1|WP_014061839.1|10497386_10498229_+|hypothetical-protein
MRYASSRTTGRRGTALASSAAALCLGALLSGCGAGGDGYVAAGAAGPDGQRSAKALPPKGGVDLVPLDEDGTGDDRDGKSGTDGKRDRGASGPTATGDGRTDGPASRAPLASPPAPGRTDGPGGGKGGSGTPGRTDDGPKGDDGPKGNGPNGDGPGEPSPSGPGSDPSGPSGSPTPTGPAVLEVGKPERTATDERWCEKVKVEFHNTGGSAVASGTVTFSTHVIDLLGIDWATLKSEEELPAPIGAGQKKEKTWTVCVDDWRVPLGMHIETRDVSVTWKP
>NC_015957.1|WP_014061838.1|10496489_10497320_+|RNA-polymerase-sigma-factor-SigF
MSVELGSSKVLNNDAPLMPDDCDAIDTRTLSRSLFLRLATLDKDSAEAGYVRDTLIELNLPLVRYAAARFRSRNEPMEDIVQVGTIGLIKAIDRFDCERGVEFPTFAMPTVVGEIKRFFRDTSWSVRVPRRLQELRLALTKASDELSQRLDRSPTVPELATALGVSEEDVVDGLAVGNAYTASSLDSPSPEDDGGEGSLADRLGYEDSALEGVEYRESLKPLLAKLPPRERQIIMLRFFANMTQSQIGEEVGISQMHVSRLLTRTLAQLREGLISD
>NC_015957.1|WP_014061837.1|10495467_10496301_+|RNA-polymerase-sigma-factor-SigF
MTVSARTAPRTPPQSDGGSESGRSRGADARALTQVLFAELSGLTPGTPEHTRVRAALIEANLPLVRYAAARFRSRNEPMEDVIQVGTIGLINAIDRFDPDRGVQFPTFAMPTVVGEIKRYFRDNVRTVHVPRRLHELWVQVNGATEDLTVLHGRSPTTAEIAERLKLSEEEVLACIEAGRSYHATSLEAAQEGDGLPGLVDRLGYEDPALAGVEHRDLVRHLLVQLPEREQRILLLRYYSNLTQSQISAELGVSQMHVSRLLSRSFARLRSANRIES
>NC_015957.1|WP_014061836.1|10495141_10495306_+|hypothetical-protein
MAQAKKIVLYMLIVFVLYTIIKTPARAADLVQVGFEGISDAATSVGDFMTELTK
>NC_015957.1|WP_014061835.1|10493878_10494904_-|6-phosphofructokinase
MRVGVLTGGGDCPGLNAAIRGIVRKGVEVHGFEFVGVRDGWRGVLEGAIVPLDVPAVRGILPRGGTILGSSRTNPLASEDGVGRVRETLAEYEVDALIAIGGEDTLGVAAALGGEGIQVVGVPKTIDNDVAGTDYTFGFDTAVNIATEAIDRLHTTAESHTRALVVEVMGRHAGWIALHSGIAGGANVILIPEQPFDIGQVCAWVENRFKIRYAPIVVVAEGAVPKKGQMVVKDSSLDEFGHVRLSGIGEWLAHEIADRTGKEARTTVLGHIQRGGTPSAFDRWLATRFGLRAIDTVKDQDFGTMVALRGTDIVRIPLAEATAGTKTVDPALYSEFGVFFG
>NC_015957.1|WP_014061834.1|10492989_10493874_+|universal-stress-protein
MSGAVVAGVDGSQRSLTAAEWAAREAARRGRVLRLVHASPPLPRRVSPVPGADAWQYVGEQMLGQTVADFRARDPDLEIEGEHTAAEPAEALLTAAAGAGLLVVGARGWGGFDGLAVGSVALRVAAMAQCPVVTVPEARCTGDGWDGAHTDEVQLGFDAHAPAQAPADFAFRAAQERGVPLRVVHAWALPPASPSAWMLTVLEEDRAMWEDQESQVVSDALRPWRERYPEVTVVPDVILLNPAEALVRASERAGLLVIGRRAATRPTELRLGPVAHPVLHHAHCPVAVVPHPAL
>NC_015957.1|WP_014061844.1|10503313_10504096_-|TetR/AcrR-family-transcriptional-regulator
MATGSRTVRPRSSVWLSERKAPKRKGDQQPVGLDHVKIVAATMRLLDAEGLSGFSMRRLAAELGVTAMSVYWYVETKDHLLELALDAAMGEIALPMEAVGPVEGQEHSPAEPRNWREQLRQLAAEYRQVMVRHSWLPALLGEYLNIGPNAVVFSNAALAVMRNSGLPDDKITSALSLVYQFVYGFGTIEGRFAARCRAAGLTQDELFHETMSSVADRMEFDESRKIMKARGGNTVEEMRDRDFTFALDLAIAGIEALRDR
>NC_015957.1|WP_014061845.1|10504175_10505699_-|MFS-transporter
MTVSTADAASAPPGQSPGGHPQRWLILAVICLAQLTVLLDNTILNVAVPSLAREMDASTAEIQWMISAYSLVQSGLLLTAGNAADRYGRKKMLVAGLALFGIGSLFASLAQGAGQLITARAGMGIGGALLMTTTLAVVVQIFDAAERTKAIGLWGAVSSLGIAAGPLIGGSLLEHFWWGSIFLINIPVALLGLIAVIWLVPESKDPVGDRPDLLGAVLSTIGMTGVVYAIIAGPEHGWTSVRVLLSAFIGVVVLTGFALWERHIPYPMLDMHFFRDRRFVGAVAGGILVAFGMGGSLFLLTQHLQFVLGYDALDAGLRTAPLALVIVALNLTGVGARLLPKLGTPLTIVSGMGLLAVGLALIAVLGADGYGGLLLGLVVMGTGIALAMPAMANAIMSAIPPEKAGVGAGVNGTLTEFGNGLGVAVLGAVLNSRFSSLLPAAAAGAGSLPAALAAARTPGDRAAVTDAFSSGLETSQLVGAAAVLAGGLLAALLLSRAERSSQEAPAA
>NC_015957.1|WP_078505918.1|10505869_10508113_-|glycosyltransferase-family-39-protein
MTRAWRGRPEDPRWARPALWALLAVTTVLYLWSLGASGYANQFYSAAVQAGSESWKAFFFGSSDAANSITVDKPPAALWPMALSVRLFGLSSWAVLVPEALMGVATVGVLYAAVRRRFSAAAGLIAGAALAVTPVAALMFRFNNPDALLCLLMVSAVYCVLRALEDARTKWLLLAGVCFGLGFLTKTLQAWLILPPLVVVYAVCAPAKFGRRIGQLLLAGLAMVVSGGWWVAIVELWPASSRPYIGGSQHNSFLELTFGYNGLGRINGNETGSVGGGGRGGGGGGGGGWGETGIDRLFGSDMGGQIAWLLPAAFILLAAGIWLTWRAGRTDTRRAAFLVWGGALLMTFATFSFMSGIFHQYYNIALAPYIAAVVGMGAALLWERRNEGGRAGSAASAVLAVTVAVTAYMSYVLLGRSADWYPWLRWAVLIGGLAAAAGLLLPARLGRKAALAAAGLGLAAGLAGPVAYTLNTVDTPKRGSIVTAGPSVAGGMGGPGGGFPGGGRMGGPGTQNGRQGAGQQGQGQGQGNQQGGQAQQGQGQGGRQGVPGGGTGGGQPGGQNGFPGGGFPGGGQSPQNGKGNAQGQGQGQNGRPGMLPGGGMGEGGRRGGGMGGLLDGQQVDAKTESKLERNADDYTWAAAAIGSQNAASYQLATQKPVMAIGGFNGSDPSPTLAQFKEYVKQGKIHYFISSGTGMGGGPGGGQGASSQITSWIEATYKKVTVGSTTLYDLTQKSSKSSASSASSKSSD
>NC_015957.1|WP_050994134.1|10508292_10509591_-|bifunctional-glycosyltransferase-family-2/GtrA-family-protein
MRTDTPLGAPPETPLQTLPVRGPVMAELGRPVLDVVIPVYNEEADLERCVRRLHDHLARTFPYGFRITIADNASTDRTPELAAHLDESIEEVTAVRLEQKGRGRALRTVWSLSEAPVLAYMDVDLSTDLKALLPLVAPLISGHSDLAIGSRLARSSRVVRGPKREFISRAYNLILRGSLAARFSDAQCGFKAIRKDVAERLLPLVEDTGWFFDTEMLVLAERAGLRIHEVPVDWVDDPNSTVHLVKTATEDLRGVWRVGRALATGGLPLDRVRRPFGDDPRDRELSGVPKGLARQLVGFCVVGALSTLVYLLLYSLFRLGTGPQMANALALLLSALGNTAANRRLTFGVRGRDRAMRHQAQGLVVFGIGLVLTSGSLAALDAAPGTASHGTELAVLIAANLAATVLRFLLFRAWVFPSDSGATTDDLRNDNR
>NC_015957.1|WP_106686040.1|10509617_10511381_-|HAMP-domain-containing-histidine-kinase
MVVSAVALIAVVCAVIGTVTTLALQSYLQGQVDDDLRASVGRFLNKPGPARELPRDDVLFVASPGQPIGTVGARIGQDGEISRSGKSNDSPMTNDMDVEGRVDSLTSGQRKALAAVPLDGQVHTIDLPGLGGYRAVAQWDHREGGIILAFPLGQTQETVNTLILVEFCVAAAGLVAAGIAGAAMVGISLRPLRRVAATATRVSELPLHSGEVALRERVPASEADPRTEVGQVGAALNRMLGHVESALAARQESETRVRQFVADASHELRTPLASIRGYAELTRRGREEIGPDTRHALGRVESEAGRMTGLVEDLLLLARLDAGRPLEYAEVDLSPLVVDAVSDARAVGSDHEWRLELPDEPTVVHGDDARLHQVLVNLLANARTHTPAGTTVTARVLWGGPQASPCPSPYPAPYGLSYGAPYGLSYGVSGGVSPGAPGTGGPRGHRKGGGSPYAPPYGSLYGSPYAAARAAVATGAFGPPQPPSYVSLEIEDDGPGIPPELLPHVFERFARGDASRSRGAGSTGLGLAIVHAVVAAHDGQVTVDSVPGRTVFGVHLPVHLPVHRGVHQGVHQAVTDSQAGHRLTTQP
>NC_015957.1|WP_014061849.1|10511640_10512378_-|response-regulator-transcription-factor
MMPTSPHGRTELLRPDGSPVRVLVVDDESALADLLSMALRYEGWEVRTAGDGAEAIRITRELRPDAVVLDVMLPDMDGLTVLGRLRRELPDIPVLFLTARDAVEDRIAGLTAGGDDYVTKPFSLEEVVARLRGLLRRSGAAAARSESVLAVGDLILDEDSHEVSRGGREIHLTATEFELLRYLMRNPRRVLSKAQILDRVWSYDFGGQANVVELYISYLRRKIDAGRSPMIHTRRGAGYLIKPGE
>NC_015957.1|WP_014061850.1|10512607_10513486_+|LLM-class-F420-dependent-oxidoreductase
MSSRPALGKIGVWTAALKTDSLPSEQVSEVAAELDELGYGAIWLGGSPSPDQAGVLLDATSRITIATGILSIWDHEAAYVAERHTALNAAHDGRFLLGLGVSHSALAGERYRRPYTAMKEYLTALDSAPSPVPASQRVLAALGPKMLELARDRAAGAHPYLVTPEHTAEARDILGKDSVLAPELKVVLDTDLDRARTTARGYLARYLALPNYTNNFRRLGFEDADFADGGSDRLISAMFALGDAEVIRARVDEFLAAGADHVAIQAVTESPLADVPRAQWRTLAEALPLDKG
>NC_015957.1|WP_014061851.1|10513561_10514446_-|amidohydrolase
MDDPAVVSVQRFWQELGLPGLIDVHTHFMPQRVLDKVWAYFDAVEPRWHITYREEEDERLAVLRAFGVRAFTSMLYPHKPDMARWLNDWSAGFAARTPDCLHTATFFPEPGVEGYVGAALEGGARVFKAHVQVGAYDPGDALLDPVWGTLAESGTPIVIHCGSGPDPGKYTGPEPVGRVLARHPRLRLIIAHMGLPEYADFLALAERYEGVYLDTTMAFTDFTESRWPFPRAERGRLAALGDRVLFGSDFPNIPYGYLHALDALTRIGQDEEWLRAVCYGNAARLFGISGISGI
>NC_015957.1|WP_014061852.1|10514752_10515379_+|hypothetical-protein
MPNRPPRATRSRAALICALGVTLLGLATAGCEDDTAASGSGQRQSATRADLATDGDGGKTLRLGEPTSITYKSGSDHIRGALRVTAMSVRKGTHAELKKAGTEPSDVRTTQPYYVTMTFENIGENSLHYPFLNTPTGLEDTNGVDDQPLITGDTEVAACPGKDPDDFAVGAKVSLCKVFLVPNGIRPSVVTYSTGDDTERPVSWKVKH
>NC_015957.1|WP_043237467.1|10516128_10516404_+|hypothetical-protein
MSSGDRLADHAHDGRFVLLGRSPYGRFAQAARPLQHRIAYTSDPASDTSPPSLFVRPDGVISWATSRVTASSDDAVLKELGTAIQRWVGTH

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_015957_15	15.1\|7441590\|38\|NC_015957\|CRISPRCasFinder	7441590-7441627	38	NC_015957.1	7261452-7261489	2	0.947
NC_015957_15	15.2\|7441653\|38\|NC_015957\|CRISPRCasFinder	7441653-7441690	38	NC_015957.1	7261515-7261552	0	1.0

1. spacer 15.1|7441590|38|NC_015957|CRISPRCasFinder matches to position: 7261452-7261489, mismatch: 2, identity: 0.947

ccagatcgccaccaacgctgctggcctcccagtcgcca	CRISPR spacer
ccaggtcgccaccaacgctgctggcctcccagccgcca	Protospacer
****.***************************.*****

2. spacer 15.2|7441653|38|NC_015957|CRISPRCasFinder matches to position: 7261515-7261552, mismatch: 0, identity: 1.0

gcacttccgccgaggccctcacggccaggtcacggccg	CRISPR spacer
gcacttccgccgaggccctcacggccaggtcacggccg	Protospacer
**************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_015957_11	11.1\|3194814\|27\|NC_015957\|CRISPRCasFinder	3194814-3194840	27	NZ_CP007794	Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence	1321937-1321963	3	0.889
NC_015957_4	4.2\|569236\|25\|NC_015957\|CRISPRCasFinder	569236-569260	25	NZ_CP034156	Rhodococcus sp. NJ-530 plasmid unnamed4, complete sequence	218944-218968	4	0.84
NC_015957_8	8.3\|2495979\|27\|NC_015957\|CRT	2495979-2496005	27	NZ_CP006570	Sodalis praecaptivus strain HS1 plasmid pHS1, complete sequence	106719-106745	4	0.852
NC_015957_8	8.4\|2496024\|27\|NC_015957\|CRT	2496024-2496050	27	NZ_CP031080	Paracoccus yeei strain CCUG 32053 plasmid pYEE2, complete sequence	216113-216139	4	0.852
NC_015957_8	8.4\|2496024\|27\|NC_015957\|CRT	2496024-2496050	27	NC_012523	Rhodococcus opacus B4 plasmid pKNR, complete sequence	74152-74178	4	0.852
NC_015957_8	8.4\|2496024\|27\|NC_015957\|CRT	2496024-2496050	27	NZ_CP029357	Azospirillum sp. CFH 70021 plasmid unnamed2	301357-301383	4	0.852
NC_015957_11	11.1\|3194814\|27\|NC_015957\|CRISPRCasFinder	3194814-3194840	27	NZ_CP032346	Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence	1089838-1089864	4	0.852
NC_015957_11	11.1\|3194814\|27\|NC_015957\|CRISPRCasFinder	3194814-3194840	27	NZ_CP012944	Ralstonia solanacearum strain IBSBF1503 plasmid unnamed, complete sequence	36987-37013	4	0.852
NC_015957_11	11.1\|3194814\|27\|NC_015957\|CRISPRCasFinder	3194814-3194840	27	NC_018452	Burkholderia phage DC1, complete genome	48272-48298	4	0.852
NC_015957_11	11.1\|3194814\|27\|NC_015957\|CRISPRCasFinder	3194814-3194840	27	FJ937737	Burkholderia cenocepacia phage BcepIL02, complete genome	49058-49084	4	0.852
NC_015957_11	11.1\|3194814\|27\|NC_015957\|CRISPRCasFinder	3194814-3194840	27	NC_012743	Burkholderia phage BcepIL02, complete genome	49058-49084	4	0.852
NC_015957_11	11.1\|3194814\|27\|NC_015957\|CRISPRCasFinder	3194814-3194840	27	NZ_CP035092	Paracoccus denitrificans strain ATCC 19367 plasmid unnamed1, complete sequence	130509-130535	4	0.852
NC_015957_11	11.1\|3194814\|27\|NC_015957\|CRISPRCasFinder	3194814-3194840	27	NC_008688	Paracoccus denitrificans PD1222 plasmid 1, complete sequence	377856-377882	4	0.852
NC_015957_8	8.4\|2496024\|27\|NC_015957\|CRT	2496024-2496050	27	NZ_AP019795	Thermus thermophilus strain AA2-29 plasmid pAA229, complete sequence	193598-193624	5	0.815
NC_015957_8	8.4\|2496024\|27\|NC_015957\|CRT	2496024-2496050	27	NZ_AP019793	Thermus thermophilus strain AA2-20 plasmid pAA220, complete sequence	3382-3408	5	0.815
NC_015957_8	8.4\|2496024\|27\|NC_015957\|CRT	2496024-2496050	27	NC_003903	Streptomyces coelicolor A3(2) plasmid SCP1, complete sequence	52487-52513	5	0.815
NC_015957_8	8.4\|2496024\|27\|NC_015957\|CRT	2496024-2496050	27	NC_003903	Streptomyces coelicolor A3(2) plasmid SCP1, complete sequence	303511-303537	5	0.815
NC_015957_8	8.4\|2496024\|27\|NC_015957\|CRT	2496024-2496050	27	NZ_CP021409	Celeribacter manganoxidans strain DY25 plasmid pDY25-E, complete sequence	13591-13617	5	0.815
NC_015957_8	8.4\|2496024\|27\|NC_015957\|CRT	2496024-2496050	27	NZ_CP043441	Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence	451821-451847	5	0.815
NC_015957_8	8.4\|2496024\|27\|NC_015957\|CRT	2496024-2496050	27	NZ_AP019010	Serratia marcescens strain AS-1 plasmid pSERAS01, complete sequence	83055-83081	5	0.815
NC_015957_8	8.4\|2496024\|27\|NC_015957\|CRT	2496024-2496050	27	NZ_CP022417	Sulfitobacter pseudonitzschiae strain SMR1 plasmid pSMR1-2, complete sequence	275478-275504	5	0.815
NC_015957_8	8.4\|2496024\|27\|NC_015957\|CRT	2496024-2496050	27	NC_015972	Serratia marcescens strain B-6493 plasmid pSM22, complete sequence	5136-5162	5	0.815
NC_015957_8	8.4\|2496024\|27\|NC_015957\|CRT	2496024-2496050	27	NZ_CP043850	Micrococcus luteus strain NCCP 15687 plasmid unnamed, complete sequence	32572-32598	5	0.815
NC_015957_8	8.4\|2496024\|27\|NC_015957\|CRT	2496024-2496050	27	CP041234	Serratia marcescens subsp. marcescens ATCC 13880 plasmid pATCC, complete sequence	39008-39034	5	0.815
NC_015957_8	8.4\|2496024\|27\|NC_015957\|CRT	2496024-2496050	27	NZ_CP012916	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p2, complete sequence	373123-373149	5	0.815
NC_015957_8	8.4\|2496024\|27\|NC_015957\|CRT	2496024-2496050	27	NZ_CP041128	Serratia marcescens strain WVU-005 plasmid pWVU-005-2, complete sequence	8680-8706	5	0.815
NC_015957_8	8.4\|2496024\|27\|NC_015957\|CRT	2496024-2496050	27	NZ_CP032341	Azospirillum brasilense strain MTCC4038 plasmid p2, complete sequence	675487-675513	5	0.815
NC_015957_8	8.4\|2496024\|27\|NC_015957\|CRT	2496024-2496050	27	NZ_CP033321	Azospirillum brasilense strain Cd plasmid p3, complete sequence	672973-672999	5	0.815
NC_015957_8	8.4\|2496024\|27\|NC_015957\|CRT	2496024-2496050	27	NZ_CP033315	Azospirillum brasilense strain Sp 7 plasmid p3, complete sequence	671161-671187	5	0.815
NC_015957_8	8.4\|2496024\|27\|NC_015957\|CRT	2496024-2496050	27	NZ_CP032346	Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence	778443-778469	5	0.815
NC_015957_11	11.1\|3194814\|27\|NC_015957\|CRISPRCasFinder	3194814-3194840	27	CP006880	Rhizobium gallicum bv. gallicum R602 plasmid pRgalR602c, complete sequence	2033006-2033032	5	0.815
NC_015957_11	11.1\|3194814\|27\|NC_015957\|CRISPRCasFinder	3194814-3194840	27	NC_004808	Streptomyces rochei plasmid pSLA2-L DNA, complete sequence	124826-124852	5	0.815
NC_015957_11	11.1\|3194814\|27\|NC_015957\|CRISPRCasFinder	3194814-3194840	27	NZ_CP049031	Fluviibacterium aquatile strain SC52 plasmid pSC52_3, complete sequence	132075-132101	5	0.815
NC_015957_11	11.1\|3194814\|27\|NC_015957\|CRISPRCasFinder	3194814-3194840	27	NZ_CP042999	Aquisphaera giovannonii strain OJF2 plasmid pOJF2_2, complete sequence	7487-7513	5	0.815
NC_015957_11	11.1\|3194814\|27\|NC_015957\|CRISPRCasFinder	3194814-3194840	27	MT723940	Mycobacterium phage Ellie, complete genome	46624-46650	5	0.815
NC_015957_11	11.1\|3194814\|27\|NC_015957\|CRISPRCasFinder	3194814-3194840	27	MF324915	Mycobacterium phage Amgine, complete genome	47601-47627	5	0.815
NC_015957_11	11.1\|3194814\|27\|NC_015957\|CRISPRCasFinder	3194814-3194840	27	NC_022063	Mycobacterium phage Phelemich, complete genome	30089-30115	5	0.815
NC_015957_11	11.1\|3194814\|27\|NC_015957\|CRISPRCasFinder	3194814-3194840	27	KF024727	Mycobacterium phage Reprobate, complete genome	30094-30120	5	0.815
NC_015957_26	26.1\|10106882\|30\|NC_015957\|CRISPRCasFinder	10106882-10106911	30	NZ_LR134451	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 9, complete sequence	268978-269007	5	0.833
NC_015957_8	8.2\|2495934\|27\|NC_015957\|CRT	2495934-2495960	27	MH669016	Streptomyces phage TrvxScott, complete genome	18900-18926	6	0.778
NC_015957_8	8.2\|2495934\|27\|NC_015957\|CRT	2495934-2495960	27	MK392363	Streptomyces phage Bowden, complete genome	18917-18943	6	0.778
NC_015957_8	8.2\|2495934\|27\|NC_015957\|CRT	2495934-2495960	27	MK392365	Streptomyces phage TinaBelcher, complete genome	18868-18894	6	0.778
NC_015957_8	8.2\|2495934\|27\|NC_015957\|CRT	2495934-2495960	27	MH651190	Streptomyces phage Thestral, complete genome	18920-18946	6	0.778
NC_015957_8	8.4\|2496024\|27\|NC_015957\|CRT	2496024-2496050	27	NZ_AP014705	Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence	664615-664641	6	0.778
NC_015957_8	8.4\|2496024\|27\|NC_015957\|CRT	2496024-2496050	27	NZ_CP046917	Paraburkholderia sp. DHF22 plasmid p1, complete sequence	101592-101618	6	0.778
NC_015957_8	8.4\|2496024\|27\|NC_015957\|CRT	2496024-2496050	27	NZ_CP016083	Streptomyces sp. SAT1 plasmid unnamed3, complete sequence	353224-353250	6	0.778
NC_015957_8	8.4\|2496024\|27\|NC_015957\|CRT	2496024-2496050	27	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	743918-743944	6	0.778
NC_015957_8	8.4\|2496024\|27\|NC_015957\|CRT	2496024-2496050	27	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	156426-156452	6	0.778
NC_015957_8	8.4\|2496024\|27\|NC_015957\|CRT	2496024-2496050	27	NZ_CP040758	Paracoccus sp. 2251 plasmid unnamed7, complete sequence	45340-45366	6	0.778
NC_015957_8	8.4\|2496024\|27\|NC_015957\|CRT	2496024-2496050	27	NZ_CP020372	Candidatus Thiodictyon syntrophicum strain Cad16T plasmid pTs485, complete sequence	304855-304881	6	0.778
NC_015957_8	8.4\|2496024\|27\|NC_015957\|CRT	2496024-2496050	27	MN945901	Mycobacterium phage Ximenita, complete genome	38096-38122	6	0.778
NC_015957_8	8.4\|2496024\|27\|NC_015957\|CRT	2496024-2496050	27	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	1656696-1656722	6	0.778
NC_015957_8	8.4\|2496024\|27\|NC_015957\|CRT	2496024-2496050	27	NZ_CP017300	Rhodococcus sp. YL-1 plasmid pYLC1, complete sequence	79822-79848	6	0.778
NC_015957_8	8.4\|2496024\|27\|NC_015957\|CRT	2496024-2496050	27	NZ_CP054028	Rhizobium sp. JKLM19E plasmid pPR19E01, complete sequence	1262471-1262497	6	0.778
NC_015957_8	8.4\|2496024\|27\|NC_015957\|CRT	2496024-2496050	27	NZ_CP005085	Sphingobium sp. TKS plasmid pTK1, complete sequence	210198-210224	6	0.778
NC_015957_8	8.4\|2496024\|27\|NC_015957\|CRT	2496024-2496050	27	NZ_CP054615	Azospirillum oryzae strain KACC 14407 plasmid unnamed1, complete sequence	36136-36162	6	0.778
NC_015957_8	8.4\|2496024\|27\|NC_015957\|CRT	2496024-2496050	27	NC_016586	Azospirillum lipoferum 4B plasmid AZO_p2, complete sequence	315584-315610	6	0.778
NC_015957_11	11.1\|3194814\|27\|NC_015957\|CRISPRCasFinder	3194814-3194840	27	NZ_CP038636	Cupriavidus oxalaticus strain X32 plasmid unnamed1, complete sequence	701533-701559	6	0.778
NC_015957_11	11.1\|3194814\|27\|NC_015957\|CRISPRCasFinder	3194814-3194840	27	MK359337	Mycobacterium phage Flabslab, complete genome	131005-131031	6	0.778
NC_015957_7	7.1\|1767269\|29\|NC_015957\|CRISPRCasFinder	1767269-1767297	29	NZ_CP029643	Arthrobacter dokdonellae isolate rhizosphere plasmid pDCT5, complete sequence	73438-73466	7	0.759
NC_015957_7	7.1\|1767269\|29\|NC_015957\|CRISPRCasFinder	1767269-1767297	29	CP054927	Streptomyces fulvissimus strain NA06532 plasmid unnamed1, complete sequence	507686-507714	7	0.759
NC_015957_16	16.1\|7923380\|33\|NC_015957\|CRISPRCasFinder	7923380-7923412	33	NZ_CP007129	Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence	195312-195344	7	0.788
NC_015957_25	25.1\|9909923\|31\|NC_015957\|CRISPRCasFinder	9909923-9909953	31	NZ_CP050104	Rhizobium leguminosarum bv. trifolii strain 4B plasmid pRL4b2, complete sequence	242143-242173	7	0.774
NC_015957_25	25.1\|9909923\|31\|NC_015957\|CRISPRCasFinder	9909923-9909953	31	NZ_CP025013	Rhizobium leguminosarum strain Norway plasmid pRLN1, complete sequence	1057837-1057867	7	0.774
NC_015957_25	25.1\|9909923\|31\|NC_015957\|CRISPRCasFinder	9909923-9909953	31	NZ_CP025507	Rhizobium leguminosarum bv. viciae strain UPM791 plasmid pRlvA, complete sequence	1223106-1223136	7	0.774
NC_015957_25	25.1\|9909923\|31\|NC_015957\|CRISPRCasFinder	9909923-9909953	31	NZ_CP050109	Rhizobium leguminosarum bv. trifolii strain 3B plasmid pRL3b2, complete sequence	242143-242173	7	0.774
NC_015957_25	25.1\|9909923\|31\|NC_015957\|CRISPRCasFinder	9909923-9909953	31	NZ_CP022666	Rhizobium leguminosarum bv. viciae strain BIHB 1217 plasmid pPR1, complete sequence	646643-646673	7	0.774
NC_015957_25	25.1\|9909923\|31\|NC_015957\|CRISPRCasFinder	9909923-9909953	31	NZ_CP050086	Rhizobium leguminosarum bv. trifolii strain 23B plasmid pRL23b7, complete sequence	242553-242583	7	0.774
NC_015957_25	25.1\|9909923\|31\|NC_015957\|CRISPRCasFinder	9909923-9909953	31	NZ_CP030761	Rhizobium leguminosarum strain ATCC 14479 plasmid unnamed1, complete sequence	356629-356659	7	0.774
NC_015957_26	26.1\|10106882\|30\|NC_015957\|CRISPRCasFinder	10106882-10106911	30	NC_017791	Deinococcus gobiensis I-0 plasmid P2, complete sequence	214987-215016	7	0.767
NC_015957_26	26.1\|10106882\|30\|NC_015957\|CRISPRCasFinder	10106882-10106911	30	NZ_CP053712	Acetobacteraceae bacterium strain PAMC 26569 plasmid unnamed5, complete sequence	60662-60691	7	0.767
NC_015957_7	7.1\|1767269\|29\|NC_015957\|CRISPRCasFinder	1767269-1767297	29	NZ_CP023017	Ralstonia solanacearum strain SL3022 plasmid unnamed, complete sequence	1324050-1324078	8	0.724
NC_015957_25	25.1\|9909923\|31\|NC_015957\|CRISPRCasFinder	9909923-9909953	31	NZ_HG938356	Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI 1141 plasmid pHAMBI1141a, complete sequence	292296-292326	8	0.742
NC_015957_26	26.1\|10106882\|30\|NC_015957\|CRISPRCasFinder	10106882-10106911	30	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	1752004-1752033	8	0.733
NC_015957_26	26.1\|10106882\|30\|NC_015957\|CRISPRCasFinder	10106882-10106911	30	NC_008043	Ruegeria sp. TM1040 megaplasmid, complete sequence	403617-403646	8	0.733
NC_015957_26	26.1\|10106882\|30\|NC_015957\|CRISPRCasFinder	10106882-10106911	30	NZ_CP042268	Pseudomonas aeruginosa strain HOU1 plasmid pHOU1-1, complete sequence	34489-34518	8	0.733
NC_015957_19	19.1\|8571705\|37\|NC_015957\|CRISPRCasFinder	8571705-8571741	37	NZ_CP023408	Streptomyces fungicidicus strain TXX3120 plasmid p1, complete sequence	685082-685118	9	0.757
NC_015957_26	26.1\|10106882\|30\|NC_015957\|CRISPRCasFinder	10106882-10106911	30	NC_011760	Methylorubrum extorquens CM4 plasmid pCMU02, complete sequence	11970-11999	9	0.7
NC_015957_25	25.1\|9909923\|31\|NC_015957\|CRISPRCasFinder	9909923-9909953	31	NZ_CP044330	Methylocystis rosea strain BRCS1 plasmid unnamed2, complete sequence	157387-157417	10	0.677
NC_015957_26	26.1\|10106882\|30\|NC_015957\|CRISPRCasFinder	10106882-10106911	30	NC_018023	Mycolicibacterium chubuense NBB4 plasmid pMYCCH.02, complete sequence	67642-67671	10	0.667
NC_015957_27	27.1\|10503230\|37\|NC_015957\|CRISPRCasFinder	10503230-10503266	37	NZ_CP020909	Rhizobium etli strain NXC12 plasmid pRetNXC12c, complete sequence	494914-494950	10	0.73
NC_015957_27	27.1\|10503230\|37\|NC_015957\|CRISPRCasFinder	10503230-10503266	37	NC_021908	Rhizobium etli bv. mimosae str. Mim1 plasmid pRetMIM1d, complete sequence	501832-501868	10	0.73

1. spacer 11.1|3194814|27|NC_015957|CRISPRCasFinder matches to NZ_CP007794 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence) position: , mismatch: 3, identity: 0.889

cccgccctcgccggtcgcgcccgaggc	CRISPR spacer
cccgcccccgccggtcgagcccgagga	Protospacer
*******.********* ********

2. spacer 4.2|569236|25|NC_015957|CRISPRCasFinder matches to NZ_CP034156 (Rhodococcus sp. NJ-530 plasmid unnamed4, complete sequence) position: , mismatch: 4, identity: 0.84

aaggcggccacgcacgcggcatacg	CRISPR spacer
aaggccgccacgcacgcggcatgga	Protospacer
***** ****************. .

3. spacer 8.3|2495979|27|NC_015957|CRT matches to NZ_CP006570 (Sodalis praecaptivus strain HS1 plasmid pHS1, complete sequence) position: , mismatch: 4, identity: 0.852

cgcagtcttgctcggtgtcgctcggat	CRISPR spacer
cgcattcttgctcggtgccgctcgcgt	Protospacer
**** ************.****** .*

4. spacer 8.4|2496024|27|NC_015957|CRT matches to NZ_CP031080 (Paracoccus yeei strain CCUG 32053 plasmid pYEE2, complete sequence) position: , mismatch: 4, identity: 0.852

tgccgccctgcccggcgcccccctgcc	CRISPR spacer
tgacgccctgctcggcgcccccctgga	Protospacer
** ********.*************

5. spacer 8.4|2496024|27|NC_015957|CRT matches to NC_012523 (Rhodococcus opacus B4 plasmid pKNR, complete sequence) position: , mismatch: 4, identity: 0.852

tgccgccctgcccggcgcccccctgcc	CRISPR spacer
tcacgccctgcccggcgccgccctggc	Protospacer
*  **************** ***** *

6. spacer 8.4|2496024|27|NC_015957|CRT matches to NZ_CP029357 (Azospirillum sp. CFH 70021 plasmid unnamed2) position: , mismatch: 4, identity: 0.852

tgccgccctgcccggcgcccccctgcc	CRISPR spacer
cgccgccctgcccggcgccatcctgac	Protospacer
.****************** .**** *

7. spacer 11.1|3194814|27|NC_015957|CRISPRCasFinder matches to NZ_CP032346 (Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence) position: , mismatch: 4, identity: 0.852

cccgccctcgccggtcgcgcccgaggc	CRISPR spacer
cccgcccccgccggtcgagcccgaaga	Protospacer
*******.********* ******.*

8. spacer 11.1|3194814|27|NC_015957|CRISPRCasFinder matches to NZ_CP012944 (Ralstonia solanacearum strain IBSBF1503 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.852

cccgccctcgccggtcgcgcccgaggc	CRISPR spacer
ctcgccctcaccggtcgcggccgagcc	Protospacer
*.*******.********* ***** *

9. spacer 11.1|3194814|27|NC_015957|CRISPRCasFinder matches to NC_018452 (Burkholderia phage DC1, complete genome) position: , mismatch: 4, identity: 0.852

cccgccctcgccggtcgcgcccgaggc	CRISPR spacer
cgcgcccgcgccggccgcgcccgagac	Protospacer
* ***** ******.**********.*

10. spacer 11.1|3194814|27|NC_015957|CRISPRCasFinder matches to FJ937737 (Burkholderia cenocepacia phage BcepIL02, complete genome) position: , mismatch: 4, identity: 0.852

cccgccctcgccggtcgcgcccgaggc	CRISPR spacer
cgcgcccgcgccggccgcgcccgagac	Protospacer
* ***** ******.**********.*

11. spacer 11.1|3194814|27|NC_015957|CRISPRCasFinder matches to NC_012743 (Burkholderia phage BcepIL02, complete genome) position: , mismatch: 4, identity: 0.852

cccgccctcgccggtcgcgcccgaggc	CRISPR spacer
cgcgcccgcgccggccgcgcccgagac	Protospacer
* ***** ******.**********.*

12. spacer 11.1|3194814|27|NC_015957|CRISPRCasFinder matches to NZ_CP035092 (Paracoccus denitrificans strain ATCC 19367 plasmid unnamed1, complete sequence) position: , mismatch: 4, identity: 0.852

cccgccctcgccggtcgcgcccgaggc	CRISPR spacer
cacgccctcgccgtccgcgcccgagac	Protospacer
* *********** .**********.*

13. spacer 11.1|3194814|27|NC_015957|CRISPRCasFinder matches to NC_008688 (Paracoccus denitrificans PD1222 plasmid 1, complete sequence) position: , mismatch: 4, identity: 0.852

cccgccctcgccggtcgcgcccgaggc	CRISPR spacer
cacgccctcgccgtccgcgcccgagac	Protospacer
* *********** .**********.*

14. spacer 8.4|2496024|27|NC_015957|CRT matches to NZ_AP019795 (Thermus thermophilus strain AA2-29 plasmid pAA229, complete sequence) position: , mismatch: 5, identity: 0.815

tgccgccctgcccggcgcccccctgcc	CRISPR spacer
cctcgccctgcccggggcccccctccc	Protospacer
. .************ ******** **

15. spacer 8.4|2496024|27|NC_015957|CRT matches to NZ_AP019793 (Thermus thermophilus strain AA2-20 plasmid pAA220, complete sequence) position: , mismatch: 5, identity: 0.815

tgccgccctgcccggcgcccccctgcc	CRISPR spacer
cctcgccctgcccggggcccccctccc	Protospacer
. .************ ******** **

16. spacer 8.4|2496024|27|NC_015957|CRT matches to NC_003903 (Streptomyces coelicolor A3(2) plasmid SCP1, complete sequence) position: , mismatch: 5, identity: 0.815

tgccgccctgcccggcgcccccctgcc	CRISPR spacer
caccgccctgccccccgcccccctgct	Protospacer
..***********  ***********.

17. spacer 8.4|2496024|27|NC_015957|CRT matches to NC_003903 (Streptomyces coelicolor A3(2) plasmid SCP1, complete sequence) position: , mismatch: 5, identity: 0.815

tgccgccctgcccggcgcccccctgcc	CRISPR spacer
caccgccctgccccccgcccccctgct	Protospacer
..***********  ***********.

18. spacer 8.4|2496024|27|NC_015957|CRT matches to NZ_CP021409 (Celeribacter manganoxidans strain DY25 plasmid pDY25-E, complete sequence) position: , mismatch: 5, identity: 0.815

tgccgccctgcccggcgcccccctgcc	CRISPR spacer
cctcgccctgccccgcgcccccctgtc	Protospacer
. .********** ***********.*

19. spacer 8.4|2496024|27|NC_015957|CRT matches to NZ_CP043441 (Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.815

tgccgccctgcccggcgcccccctgcc	CRISPR spacer
cgccgccctgcccggcgccgccccggt	Protospacer
.****************** ***.* .

20. spacer 8.4|2496024|27|NC_015957|CRT matches to NZ_AP019010 (Serratia marcescens strain AS-1 plasmid pSERAS01, complete sequence) position: , mismatch: 5, identity: 0.815

tgccgccctgcccggcgcccccctgcc	CRISPR spacer
aaccgccctgcccggccgccccctggc	Protospacer
 .**************  ******* *

21. spacer 8.4|2496024|27|NC_015957|CRT matches to NZ_CP022417 (Sulfitobacter pseudonitzschiae strain SMR1 plasmid pSMR1-2, complete sequence) position: , mismatch: 5, identity: 0.815

tgccgccctgcccggcgcccccctgcc	CRISPR spacer
cgacgccctgcccggcaccccgctgcg	Protospacer
.* *************.**** ****

22. spacer 8.4|2496024|27|NC_015957|CRT matches to NC_015972 (Serratia marcescens strain B-6493 plasmid pSM22, complete sequence) position: , mismatch: 5, identity: 0.815

tgccgccctgcccggcgcccccctgcc	CRISPR spacer
aaccgccctgcccggccgccccctggc	Protospacer
 .**************  ******* *

23. spacer 8.4|2496024|27|NC_015957|CRT matches to NZ_CP043850 (Micrococcus luteus strain NCCP 15687 plasmid unnamed, complete sequence) position: , mismatch: 5, identity: 0.815

tgccgccctgcccggcgcccccctgcc	CRISPR spacer
ggccgccctgcccggggcccccgggca	Protospacer
 ************** ******  **

24. spacer 8.4|2496024|27|NC_015957|CRT matches to CP041234 (Serratia marcescens subsp. marcescens ATCC 13880 plasmid pATCC, complete sequence) position: , mismatch: 5, identity: 0.815

tgccgccctgcccggcgcccccctgcc	CRISPR spacer
aaccgccctgcccggccgccccctggc	Protospacer
 .**************  ******* *

25. spacer 8.4|2496024|27|NC_015957|CRT matches to NZ_CP012916 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p2, complete sequence) position: , mismatch: 5, identity: 0.815

tgccgccctgcccggcgcccccctgcc	CRISPR spacer
cgccgccctgcccggcggccccatcgc	Protospacer
.**************** **** *  *

26. spacer 8.4|2496024|27|NC_015957|CRT matches to NZ_CP041128 (Serratia marcescens strain WVU-005 plasmid pWVU-005-2, complete sequence) position: , mismatch: 5, identity: 0.815

tgccgccctgcccggcgcccccctgcc	CRISPR spacer
aaccgccctgcccggccgccccctggc	Protospacer
 .**************  ******* *

27. spacer 8.4|2496024|27|NC_015957|CRT matches to NZ_CP032341 (Azospirillum brasilense strain MTCC4038 plasmid p2, complete sequence) position: , mismatch: 5, identity: 0.815

tgccgccctgcccggcgcccccctgcc	CRISPR spacer
cgccgccctgcccggcggccccatcgc	Protospacer
.**************** **** *  *

28. spacer 8.4|2496024|27|NC_015957|CRT matches to NZ_CP033321 (Azospirillum brasilense strain Cd plasmid p3, complete sequence) position: , mismatch: 5, identity: 0.815

tgccgccctgcccggcgcccccctgcc	CRISPR spacer
cgccgccctgcccggcggccccatcgc	Protospacer
.**************** **** *  *

29. spacer 8.4|2496024|27|NC_015957|CRT matches to NZ_CP033315 (Azospirillum brasilense strain Sp 7 plasmid p3, complete sequence) position: , mismatch: 5, identity: 0.815

tgccgccctgcccggcgcccccctgcc	CRISPR spacer
cgccgccctgcccggcggccccatcgc	Protospacer
.**************** **** *  *

30. spacer 8.4|2496024|27|NC_015957|CRT matches to NZ_CP032346 (Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence) position: , mismatch: 5, identity: 0.815

tgccgccctgcccggcgcccccctgcc	CRISPR spacer
cgccgccctgcccggcggccccgtcgc	Protospacer
.**************** **** *  *

31. spacer 11.1|3194814|27|NC_015957|CRISPRCasFinder matches to CP006880 (Rhizobium gallicum bv. gallicum R602 plasmid pRgalR602c, complete sequence) position: , mismatch: 5, identity: 0.815

cccgccctcgccggtcgcgcccgaggc	CRISPR spacer
cagatcctcgccggtcgcgcccgcggc	Protospacer
*  ..****************** ***

32. spacer 11.1|3194814|27|NC_015957|CRISPRCasFinder matches to NC_004808 (Streptomyces rochei plasmid pSLA2-L DNA, complete sequence) position: , mismatch: 5, identity: 0.815

cccgccctcgccggtcgcgcccgaggc	CRISPR spacer
cccgcccccggcggtcgcgcccgcgcg	Protospacer
*******.** ************ *

33. spacer 11.1|3194814|27|NC_015957|CRISPRCasFinder matches to NZ_CP049031 (Fluviibacterium aquatile strain SC52 plasmid pSC52_3, complete sequence) position: , mismatch: 5, identity: 0.815

cccgccctcgccggtcgcgcccgaggc	CRISPR spacer
cccgccatggccggtcgcgcccgcgta	Protospacer
****** * ************** *

34. spacer 11.1|3194814|27|NC_015957|CRISPRCasFinder matches to NZ_CP042999 (Aquisphaera giovannonii strain OJF2 plasmid pOJF2_2, complete sequence) position: , mismatch: 5, identity: 0.815

cccgccctcgccggtcgcgcccgaggc	CRISPR spacer
cccgccctcgccagccgcgcccgcccc	Protospacer
************.*.********   *

35. spacer 11.1|3194814|27|NC_015957|CRISPRCasFinder matches to MT723940 (Mycobacterium phage Ellie, complete genome) position: , mismatch: 5, identity: 0.815

cccgccctcgccggtcgcgcccgaggc	CRISPR spacer
cccgcccccgccggtggcgcccggcgt	Protospacer
*******.******* *******. *.

36. spacer 11.1|3194814|27|NC_015957|CRISPRCasFinder matches to MF324915 (Mycobacterium phage Amgine, complete genome) position: , mismatch: 5, identity: 0.815

cccgccctcgccggtcgcgcccgaggc	CRISPR spacer
cccgcccccgccggtggcgcccggcgt	Protospacer
*******.******* *******. *.

37. spacer 11.1|3194814|27|NC_015957|CRISPRCasFinder matches to NC_022063 (Mycobacterium phage Phelemich, complete genome) position: , mismatch: 5, identity: 0.815

cccgccctcgccggtcgcgcccgaggc	CRISPR spacer
cccgccgccgccggtcgcgcccgcctc	Protospacer
****** .***************   *

38. spacer 11.1|3194814|27|NC_015957|CRISPRCasFinder matches to KF024727 (Mycobacterium phage Reprobate, complete genome) position: , mismatch: 5, identity: 0.815

cccgccctcgccggtcgcgcccgaggc	CRISPR spacer
cccgccgccgccggtcgcgcccgcctc	Protospacer
****** .***************   *

39. spacer 26.1|10106882|30|NC_015957|CRISPRCasFinder matches to NZ_LR134451 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 9, complete sequence) position: , mismatch: 5, identity: 0.833

ttgggggggtggcggccgggcgacgggcgg	CRISPR spacer
tggcgcgggtggcggccgtgcggcgggcgg	Protospacer
* * * ************ ***.*******

40. spacer 8.2|2495934|27|NC_015957|CRT matches to MH669016 (Streptomyces phage TrvxScott, complete genome) position: , mismatch: 6, identity: 0.778

tgtcgctcggcttggcgcagtcttgcc	CRISPR spacer
agtcgctcggcttggcgaagtccggga	Protospacer
 **************** ****. *

41. spacer 8.2|2495934|27|NC_015957|CRT matches to MK392363 (Streptomyces phage Bowden, complete genome) position: , mismatch: 6, identity: 0.778

tgtcgctcggcttggcgcagtcttgcc	CRISPR spacer
agtcgctcggcttggcgaagtcgggga	Protospacer
 **************** ****  *

42. spacer 8.2|2495934|27|NC_015957|CRT matches to MK392365 (Streptomyces phage TinaBelcher, complete genome) position: , mismatch: 6, identity: 0.778

tgtcgctcggcttggcgcagtcttgcc	CRISPR spacer
agtcgctcggcttggcgaagtcgggga	Protospacer
 **************** ****  *

43. spacer 8.2|2495934|27|NC_015957|CRT matches to MH651190 (Streptomyces phage Thestral, complete genome) position: , mismatch: 6, identity: 0.778

tgtcgctcggcttggcgcagtcttgcc	CRISPR spacer
agtcgctcggcttggcgaagtccggga	Protospacer
 **************** ****. *

44. spacer 8.4|2496024|27|NC_015957|CRT matches to NZ_AP014705 (Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence) position: , mismatch: 6, identity: 0.778

tgccgccctgcccggcgcccccctgcc	CRISPR spacer
ctccgccctgcccggcgcccccgcccg	Protospacer
. ******************** . *

45. spacer 8.4|2496024|27|NC_015957|CRT matches to NZ_CP046917 (Paraburkholderia sp. DHF22 plasmid p1, complete sequence) position: , mismatch: 6, identity: 0.778

tgccgccctgcccggcgcccccctgcc	CRISPR spacer
aaacgccctgcccggcgcccgcctgga	Protospacer
 . ***************** ****

46. spacer 8.4|2496024|27|NC_015957|CRT matches to NZ_CP016083 (Streptomyces sp. SAT1 plasmid unnamed3, complete sequence) position: , mismatch: 6, identity: 0.778

tgccgccctgcccggcgcccccctgcc	CRISPR spacer
cgccgccctgcccggcgcgcccgcggg	Protospacer
.***************** *** .*

47. spacer 8.4|2496024|27|NC_015957|CRT matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 6, identity: 0.778

tgccgccctgcccggcgcccccctgcc	CRISPR spacer
cgccgccctgcccggcgccctggcgct	Protospacer
.*******************.  .**.

48. spacer 8.4|2496024|27|NC_015957|CRT matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 6, identity: 0.778

tgccgccctgcccggcgcccccctgcc	CRISPR spacer
gcccgccctgcccggcgccgcccgaac	Protospacer
  ***************** *** . *

49. spacer 8.4|2496024|27|NC_015957|CRT matches to NZ_CP040758 (Paracoccus sp. 2251 plasmid unnamed7, complete sequence) position: , mismatch: 6, identity: 0.778

tgccgccctgcccggcgcccccctgcc	CRISPR spacer
gaccgccctgcgcggcgccgccctgtg	Protospacer
 .********* ******* *****.

50. spacer 8.4|2496024|27|NC_015957|CRT matches to NZ_CP020372 (Candidatus Thiodictyon syntrophicum strain Cad16T plasmid pTs485, complete sequence) position: , mismatch: 6, identity: 0.778

tgccgccctgcccggcgcccccctgcc	CRISPR spacer
gatcgccctgcccggtgccctcctgca	Protospacer
 ..************.****.*****

51. spacer 8.4|2496024|27|NC_015957|CRT matches to MN945901 (Mycobacterium phage Ximenita, complete genome) position: , mismatch: 6, identity: 0.778

tgccgccctgcccggcgcccccctgcc	CRISPR spacer
cgccgccctgcccggcgcccagcgagc	Protospacer
.*******************  * . *

52. spacer 8.4|2496024|27|NC_015957|CRT matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 6, identity: 0.778

tgccgccctgcccggcgcccccctgcc	CRISPR spacer
gcccgccctgcccggcgccgcccgaac	Protospacer
  ***************** *** . *

53. spacer 8.4|2496024|27|NC_015957|CRT matches to NZ_CP017300 (Rhodococcus sp. YL-1 plasmid pYLC1, complete sequence) position: , mismatch: 6, identity: 0.778

tgccgccctgcccggcgcccccctgcc	CRISPR spacer
ctgcgccctgcccggcgcccatctgca	Protospacer
.  ***************** .****

54. spacer 8.4|2496024|27|NC_015957|CRT matches to NZ_CP054028 (Rhizobium sp. JKLM19E plasmid pPR19E01, complete sequence) position: , mismatch: 6, identity: 0.778

tgccgccctgcccggcgcccccctgcc	CRISPR spacer
tgccgccctgcccggcgccatcgccct	Protospacer
******************* .* . *.

55. spacer 8.4|2496024|27|NC_015957|CRT matches to NZ_CP005085 (Sphingobium sp. TKS plasmid pTK1, complete sequence) position: , mismatch: 6, identity: 0.778

tgccgccctgcccggcgcccccctgcc	CRISPR spacer
cgccgccctgccaggcgcccccgcccg	Protospacer
.*********** ********* . *

56. spacer 8.4|2496024|27|NC_015957|CRT matches to NZ_CP054615 (Azospirillum oryzae strain KACC 14407 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.778

tgccgccctgcccggcgcccccctgcc	CRISPR spacer
caccgccctgcccggcgccggcctgaa	Protospacer
..*****************  ****

57. spacer 8.4|2496024|27|NC_015957|CRT matches to NC_016586 (Azospirillum lipoferum 4B plasmid AZO_p2, complete sequence) position: , mismatch: 6, identity: 0.778

tgccgccctgcccggcgcccccctgcc	CRISPR spacer
tgccgcccggcccggcgcccgccgcgg	Protospacer
******** *********** **

58. spacer 11.1|3194814|27|NC_015957|CRISPRCasFinder matches to NZ_CP038636 (Cupriavidus oxalaticus strain X32 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.778

cccgccctcgccggtcgcgcccgaggc	CRISPR spacer
accgccctcgccggccgcgccccatcg	Protospacer
 *************.******* *

59. spacer 11.1|3194814|27|NC_015957|CRISPRCasFinder matches to MK359337 (Mycobacterium phage Flabslab, complete genome) position: , mismatch: 6, identity: 0.778

cccgccctcgccggtcgcgcccgaggc	CRISPR spacer
tgtacccctgccggtcgcgcccgaggc	Protospacer
. ..***..******************

60. spacer 7.1|1767269|29|NC_015957|CRISPRCasFinder matches to NZ_CP029643 (Arthrobacter dokdonellae isolate rhizosphere plasmid pDCT5, complete sequence) position: , mismatch: 7, identity: 0.759

aagcccggaccagagcctggcccggacca	CRISPR spacer
ggtcctggaccagcgcctggcccggacgg	Protospacer
.. **.******* ************* .

61. spacer 7.1|1767269|29|NC_015957|CRISPRCasFinder matches to CP054927 (Streptomyces fulvissimus strain NA06532 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.759

aagcccggaccagagcctggcccggacca	CRISPR spacer
ctgcccggaccagggcctggccgggcgcc	Protospacer
  ***********.******** **  *

62. spacer 16.1|7923380|33|NC_015957|CRISPRCasFinder matches to NZ_CP007129 (Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence) position: , mismatch: 7, identity: 0.788

aacgggcgcccgttcccgcctgacgagcgcctc	CRISPR spacer
agcccggggccgttcccgcctaacgcgcgcctc	Protospacer
*.*  * * ************.*** *******

63. spacer 25.1|9909923|31|NC_015957|CRISPRCasFinder matches to NZ_CP050104 (Rhizobium leguminosarum bv. trifolii strain 4B plasmid pRL4b2, complete sequence) position: , mismatch: 7, identity: 0.774

gcaacgaaggtccgcaatgtgtcgaggtggc	CRISPR spacer
gcaacgaagatccgcgatgtgtcgttcacgc	Protospacer
*********.*****.********     **

64. spacer 25.1|9909923|31|NC_015957|CRISPRCasFinder matches to NZ_CP025013 (Rhizobium leguminosarum strain Norway plasmid pRLN1, complete sequence) position: , mismatch: 7, identity: 0.774

gcaacgaaggtccgcaatgtgtcgaggtggc	CRISPR spacer
gcaacgaagatccgcaacgtgtcgttcacgc	Protospacer
*********.*******.******     **

65. spacer 25.1|9909923|31|NC_015957|CRISPRCasFinder matches to NZ_CP025507 (Rhizobium leguminosarum bv. viciae strain UPM791 plasmid pRlvA, complete sequence) position: , mismatch: 7, identity: 0.774

gcaacgaaggtccgcaatgtgtcgaggtggc	CRISPR spacer
gcaacgaagatccgcgatgtgtcgttcacgc	Protospacer
*********.*****.********     **

66. spacer 25.1|9909923|31|NC_015957|CRISPRCasFinder matches to NZ_CP050109 (Rhizobium leguminosarum bv. trifolii strain 3B plasmid pRL3b2, complete sequence) position: , mismatch: 7, identity: 0.774

gcaacgaaggtccgcaatgtgtcgaggtggc	CRISPR spacer
gcaacgaagatccgcgatgtgtcgttcacgc	Protospacer
*********.*****.********     **

67. spacer 25.1|9909923|31|NC_015957|CRISPRCasFinder matches to NZ_CP022666 (Rhizobium leguminosarum bv. viciae strain BIHB 1217 plasmid pPR1, complete sequence) position: , mismatch: 7, identity: 0.774

gcaacgaaggtccgcaatgtgtcgaggtggc	CRISPR spacer
gcaacgaagatccgcgatgtgtcgttcacgc	Protospacer
*********.*****.********     **

68. spacer 25.1|9909923|31|NC_015957|CRISPRCasFinder matches to NZ_CP050086 (Rhizobium leguminosarum bv. trifolii strain 23B plasmid pRL23b7, complete sequence) position: , mismatch: 7, identity: 0.774

gcaacgaaggtccgcaatgtgtcgaggtggc	CRISPR spacer
gcaacgaagatccgcgatgtgtcgttcacgc	Protospacer
*********.*****.********     **

69. spacer 25.1|9909923|31|NC_015957|CRISPRCasFinder matches to NZ_CP030761 (Rhizobium leguminosarum strain ATCC 14479 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.774

gcaacgaaggtccgcaatgtgtcgaggtggc	CRISPR spacer
gcaacgaagatccgcgatgtgtcgttcacgc	Protospacer
*********.*****.********     **

70. spacer 26.1|10106882|30|NC_015957|CRISPRCasFinder matches to NC_017791 (Deinococcus gobiensis I-0 plasmid P2, complete sequence) position: , mismatch: 7, identity: 0.767

ttgggggggtggcggccgggcgacgggcgg	CRISPR spacer
gcctgggggtggcggccggtcgacgtgcga	Protospacer
 .  *************** ***** ***.

71. spacer 26.1|10106882|30|NC_015957|CRISPRCasFinder matches to NZ_CP053712 (Acetobacteraceae bacterium strain PAMC 26569 plasmid unnamed5, complete sequence) position: , mismatch: 7, identity: 0.767

ttgggggggtggcggccgggcgacgggcgg	CRISPR spacer
tcgagcatgtcgcggccgggcgacgggcga	Protospacer
*.*.* . ** ******************.

72. spacer 7.1|1767269|29|NC_015957|CRISPRCasFinder matches to NZ_CP023017 (Ralstonia solanacearum strain SL3022 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.724

aagcccggaccagagcctggcccggacca	CRISPR spacer
cagccccgaccagagcccggcccgagtat	Protospacer
 ***** **********.******...

73. spacer 25.1|9909923|31|NC_015957|CRISPRCasFinder matches to NZ_HG938356 (Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI 1141 plasmid pHAMBI1141a, complete sequence) position: , mismatch: 8, identity: 0.742

gcaacgaaggtccgcaatgtgtcgaggtggc	CRISPR spacer
gcaacgaagatccgcgatgtgtccttcacgc	Protospacer
*********.*****.*******      **

74. spacer 26.1|10106882|30|NC_015957|CRISPRCasFinder matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 8, identity: 0.733

ttgggggggtggcggccgggcgacgggcgg	CRISPR spacer
agccgggggtggcggctgggcgacggcggt	Protospacer
    ************.*********  *

75. spacer 26.1|10106882|30|NC_015957|CRISPRCasFinder matches to NC_008043 (Ruegeria sp. TM1040 megaplasmid, complete sequence) position: , mismatch: 8, identity: 0.733

-----ttgggggggtggcggccgggcgacgggcgg	CRISPR spacer
cgccctc-----ggtggcggcccggagacgggcgg	Protospacer
     *.     ********** ** *********

76. spacer 26.1|10106882|30|NC_015957|CRISPRCasFinder matches to NZ_CP042268 (Pseudomonas aeruginosa strain HOU1 plasmid pHOU1-1, complete sequence) position: , mismatch: 8, identity: 0.733

ttgggggggtggcggccgggcgacgggcgg	CRISPR spacer
ccgcgacactggcggccgggcgaccggcgg	Protospacer
..* *. . *************** *****

77. spacer 19.1|8571705|37|NC_015957|CRISPRCasFinder matches to NZ_CP023408 (Streptomyces fungicidicus strain TXX3120 plasmid p1, complete sequence) position: , mismatch: 9, identity: 0.757

ggtgcggcatgtcccccgggagccgccggggtgccgt	CRISPR spacer
agtgcgccatgtcctccgggagccgccacgggatcgc	Protospacer
.***** *******.************. ** ..**.

78. spacer 26.1|10106882|30|NC_015957|CRISPRCasFinder matches to NC_011760 (Methylorubrum extorquens CM4 plasmid pCMU02, complete sequence) position: , mismatch: 9, identity: 0.7

ttgggggggtggcggccgggcgacgggcgg	CRISPR spacer
gggacacagtgggggccgggcgacgggcgc	Protospacer
  *. . .**** ****************

79. spacer 25.1|9909923|31|NC_015957|CRISPRCasFinder matches to NZ_CP044330 (Methylocystis rosea strain BRCS1 plasmid unnamed2, complete sequence) position: , mismatch: 10, identity: 0.677

gcaacgaaggtccgcaatgtgtcgaggtggc	CRISPR spacer
atcgtaaaggtccgcaatgggtcaaggtgag	Protospacer
.. ...************* ***.*****.

80. spacer 26.1|10106882|30|NC_015957|CRISPRCasFinder matches to NC_018023 (Mycolicibacterium chubuense NBB4 plasmid pMYCCH.02, complete sequence) position: , mismatch: 10, identity: 0.667

ttgggggggtggcggccgggcgacgggcgg	CRISPR spacer
catccaaggtggcggcccggcgacgggcac	Protospacer
.    ..********** **********.

81. spacer 27.1|10503230|37|NC_015957|CRISPRCasFinder matches to NZ_CP020909 (Rhizobium etli strain NXC12 plasmid pRetNXC12c, complete sequence) position: , mismatch: 10, identity: 0.73

ggcaccccggcccgcccggcacgcgcatcgtcgatga	CRISPR spacer
tgcaatattgcccgcctggcgcgcgcatcgtcgatac	Protospacer
 *** . . *******.***.**************.

82. spacer 27.1|10503230|37|NC_015957|CRISPRCasFinder matches to NC_021908 (Rhizobium etli bv. mimosae str. Mim1 plasmid pRetMIM1d, complete sequence) position: , mismatch: 10, identity: 0.73

ggcaccccggcccgcccggcacgcgcatcgtcgatga	CRISPR spacer
tgcaatattgcccgcctggcgcgcgcatcgtcgatac	Protospacer
 *** . . *******.***.**************.

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

4463064 : 4511221

Bacillus_phage(27.27%)

plate,tail,holin

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014057251.1\|4463064_4464585_+\|holin	glucose-methanol-choline oxidoreductase	A0A1V0SI18	Klosneuvirus	3.9e-62	33.2
WP_014057252.1\|4464744_4464939_+	hypothetical protein	NA	NA	NA	NA
WP_014057253.1\|4464975_4466364_-	cyclic nucleotide-binding domain-containing protein	A0A2K9L690	Tupanvirus	4.7e-22	31.2
WP_014057254.1\|4466435_4467848_-	cyclic nucleotide-binding domain-containing protein	A0A2K9L690	Tupanvirus	4.6e-25	31.9
WP_014057255.1\|4468249_4469155_+	hypothetical protein	NA	NA	NA	NA
WP_014057256.1\|4469209_4469710_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_078505764.1\|4469690_4470923_-	ROK family transcriptional regulator	NA	NA	NA	NA
WP_014057258.1\|4471047_4472505_-	xylulokinase	NA	NA	NA	NA
WP_014057259.1\|4472623_4473796_+	xylose isomerase	NA	NA	NA	NA
WP_014057260.1\|4473852_4474956_-	pectinesterase	NA	NA	NA	NA
WP_014057261.1\|4475260_4476538_-	hypothetical protein	NA	NA	NA	NA
WP_014057262.1\|4476534_4479471_-	DEAD/DEAH box helicase	D4P754	Rhodococcus_phage	1.9e-41	31.8
WP_014057263.1\|4479613_4479796_+	hypothetical protein	NA	NA	NA	NA
WP_014057264.1\|4480107_4480905_-	hypothetical protein	NA	NA	NA	NA
WP_043239173.1\|4481007_4481544_-	PadR family transcriptional regulator	NA	NA	NA	NA
WP_043239177.1\|4482285_4482867_-	methyltransferase domain-containing protein	NA	NA	NA	NA
WP_014057267.1\|4483146_4483665_+	roadblock/LC7 domain-containing protein	NA	NA	NA	NA
WP_014057268.1\|4483633_4484827_+	alcohol dehydrogenase catalytic domain-containing protein	NA	NA	NA	NA
WP_014057269.1\|4484880_4485309_-	PPOX class F420-dependent oxidoreductase	NA	NA	NA	NA
WP_014057270.1\|4485428_4485833_+	roadblock/LC7 domain-containing protein	NA	NA	NA	NA
WP_106685910.1\|4486103_4486895_+	hypothetical protein	NA	NA	NA	NA
WP_014057272.1\|4486925_4487852_-	acyl-CoA thioesterase II	NA	NA	NA	NA
WP_014057273.1\|4487913_4490442_-	DEAD/DEAH box helicase	M1I6E2	Acanthocystis_turfacea_Chlorella_virus	1.4e-45	32.5
WP_014057274.1\|4490578_4491370_+	metal-dependent hydrolase	NA	NA	NA	NA
WP_014057275.1\|4491414_4493196_-	ABC transporter ATP-binding protein	F2Y1V6	Organic_Lake_phycodnavirus	3.9e-05	25.0
WP_014057276.1\|4493192_4495097_-	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	2.4e-05	21.1
WP_014057277.1\|4495251_4495992_+	L,D-transpeptidase family protein	NA	NA	NA	NA
WP_014057278.1\|4496229_4496670_-	MarR family transcriptional regulator	NA	NA	NA	NA
WP_014057279.1\|4496805_4498659_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	1.4e-42	25.8
WP_014057280.1\|4498693_4499494_-	transcriptional regulator	NA	NA	NA	NA
WP_014057281.1\|4499669_4499867_-	hypothetical protein	NA	NA	NA	NA
WP_014057282.1\|4500045_4500624_+	DUF4255 domain-containing protein	NA	NA	NA	NA
WP_014057283.1\|4500620_4501346_+	carboxypeptidase regulatory-like domain-containing protein	NA	NA	NA	NA
WP_014057284.1\|4501356_4503621_+\|tail	tail protein	J9PVC2	Bacillus_phage	2.4e-47	30.9
WP_014057285.1\|4503641_4504097_+\|tail	phage tail protein	NA	NA	NA	NA
WP_014057286.1\|4504098_4505592_+\|tail	tail protein	H6WFT7	Cyanophage	4.9e-17	30.8
WP_014057287.1\|4505588_4506107_+\|tail	phage tail protein	T2KT02	uncultured_phage	6.4e-09	38.7
WP_043236117.1\|4506103_4506298_+	hypothetical protein	NA	NA	NA	NA
WP_014057289.1\|4506294_4506966_+	LysM peptidoglycan-binding domain-containing protein	NA	NA	NA	NA
WP_014057290.1\|4506976_4508158_+	phage late control D family protein	NA	NA	NA	NA
WP_043236120.1\|4508154_4508856_+	type IV secretion protein Rhs	NA	NA	NA	NA
WP_014057292.1\|4508852_4509275_+	GPW/gp25 family protein	NA	NA	NA	NA
WP_014057293.1\|4509271_4511221_+\|plate	putative baseplate assembly protein	NA	NA	NA	NA

DBSCAN-SWA_2

5114991 : 5125456

Virus_Rctr41k(33.33%)

transposase,integrase

attL 5106147:5106161|attR 5126651:5126665

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
5106147:5106161	attL	NA	NA	NA	NA
WP_014057697.1\|5114991_5116071_-\|integrase	site-specific integrase	A0A1P8DJP1	Virus_Rctr41k	5.6e-07	32.4
WP_014057698.1\|5116529_5116913_+	hypothetical protein	NA	NA	NA	NA
WP_014057699.1\|5116912_5118352_+	caspase family protein	NA	NA	NA	NA
WP_078505316.1\|5118994_5119105_+\|transposase	transposase	NA	NA	NA	NA
WP_078505319.1\|5119101_5119293_+	hypothetical protein	A0A0N7C1Z2	Escherichia_phage	7.1e-06	48.3
WP_150112905.1\|5119363_5119861_+\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_167543214.1\|5119933_5120188_+\|transposase	transposase	NA	NA	NA	NA
WP_167543215.1\|5120225_5121836_-\|transposase	IS1182 family transposase	NA	NA	NA	NA
WP_014055863.1\|5124169_5125456_+\|transposase	IS256 family transposase	A0A220NQR7	Corynebacterium_phage	2.1e-32	26.7
5126651:5126665	attR	NA	NA	NA	NA

DBSCAN-SWA_3

5140340 : 5212192

Tupanvirus(28.57%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014057717.1\|5140340_5141090_-\|transposase	IS5/IS1182 family transposase	NA	NA	NA	NA
WP_167543216.1\|5142570_5142840_+	hypothetical protein	NA	NA	NA	NA
WP_014057719.1\|5143148_5144216_+	O-methyltransferase	NA	NA	NA	NA
WP_043236264.1\|5144242_5145571_+	MHS family MFS transporter	NA	NA	NA	NA
WP_043236267.1\|5145950_5147054_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_014057722.1\|5147066_5148359_+	ATP-grasp domain-containing protein	NA	NA	NA	NA
WP_014057723.1\|5148358_5151520_+	non-ribosomal peptide synthetase	A0A2K9KZV5	Tupanvirus	5.2e-69	31.8
WP_014057724.1\|5151516_5152755_+	MFS transporter	NA	NA	NA	NA
WP_014057725.1\|5152920_5154228_+	NtaA/DmoA family FMN-dependent monooxygenase	NA	NA	NA	NA
WP_014057726.1\|5154388_5154727_-	DUF190 domain-containing protein	NA	NA	NA	NA
WP_014057727.1\|5155239_5156004_+	hypothetical protein	NA	NA	NA	NA
WP_014057728.1\|5156028_5157081_+	iron-containing redox enzyme family protein	NA	NA	NA	NA
WP_014057729.1\|5157109_5158624_+	hypothetical protein	NA	NA	NA	NA
WP_086019694.1\|5158637_5159810_+	alpha-hydroxy-acid oxidizing enzyme	NA	NA	NA	NA
WP_014057731.1\|5159852_5161241_+	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_078505789.1\|5161310_5162042_+	pyridoxamine 5'-phosphate oxidase family protein	NA	NA	NA	NA
WP_014057733.1\|5162160_5163732_+	glycerol kinase GlpK	NA	NA	NA	NA
WP_106685926.1\|5163743_5165066_+	cation/H(+) antiporter	NA	NA	NA	NA
WP_014057735.1\|5165013_5166075_-	AraC family transcriptional regulator	NA	NA	NA	NA
WP_014057736.1\|5166563_5166920_+	antibiotic biosynthesis monooxygenase	NA	NA	NA	NA
WP_014057737.1\|5166916_5168293_+	cation:proton antiporter	NA	NA	NA	NA
WP_014057738.1\|5168298_5169816_+	glycerol kinase GlpK	NA	NA	NA	NA
WP_014057739.1\|5169869_5170517_-	AhpC/TSA family protein	NA	NA	NA	NA
WP_014057740.1\|5171256_5173155_+	1-deoxy-D-xylulose-5-phosphate synthase	NA	NA	NA	NA
WP_014057741.1\|5173366_5173651_-	hypothetical protein	NA	NA	NA	NA
WP_106685694.1\|5174507_5175305_-	2OG-Fe dioxygenase family protein	NA	NA	NA	NA
WP_050993718.1\|5175507_5177013_-	MFS transporter	A0A0M3UL24	Mycobacterium_phage	3.9e-38	35.5
WP_043236271.1\|5177003_5177291_-	hypothetical protein	NA	NA	NA	NA
WP_106685695.1\|5177501_5178782_-	MFS transporter	NA	NA	NA	NA
WP_106685696.1\|5182468_5193730_+	type I polyketide synthase	A0A2K9KZV5	Tupanvirus	1.4e-60	34.3
WP_014057749.1\|5193726_5195070_+	hypothetical protein	NA	NA	NA	NA
WP_167543217.1\|5196031_5196202_+	hypothetical protein	NA	NA	NA	NA
WP_014057751.1\|5196240_5196810_+\|transposase	transposase	A0A1B3AZF8	Gordonia_phage	1.9e-09	44.3
WP_106685927.1\|5197032_5197656_-	GIY-YIG nuclease family protein	NA	NA	NA	NA
WP_043236273.1\|5198241_5199783_+\|transposase	IS21 family transposase	NA	NA	NA	NA
WP_050993979.1\|5199971_5200697_+	ATP-binding protein	K4HZD4	Acidithiobacillus_phage	2.1e-13	28.1
WP_014057755.1\|5200708_5201113_-	hypothetical protein	NA	NA	NA	NA
WP_043236276.1\|5202340_5203204_-	hypothetical protein	NA	NA	NA	NA
WP_014057757.1\|5203902_5204268_-	hypothetical protein	NA	NA	NA	NA
WP_014057758.1\|5204496_5204853_-	hypothetical protein	NA	NA	NA	NA
WP_014057759.1\|5204866_5205493_-	hypothetical protein	NA	NA	NA	NA
WP_086019633.1\|5206763_5207767_-\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_014057763.1\|5208277_5210755_+	DEAD/DEAH box helicase family protein	A0A2I5ARD8	Synechococcus_phage	4.2e-05	38.9
WP_167543214.1\|5210998_5211253_-\|transposase	transposase	NA	NA	NA	NA
WP_150112905.1\|5211325_5211823_-\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_078505319.1\|5211893_5212085_-	hypothetical protein	A0A0N7C1Z2	Escherichia_phage	7.1e-06	48.3
WP_078505316.1\|5212081_5212192_-\|transposase	transposase	NA	NA	NA	NA

DBSCAN-SWA_4

6282178 : 6309910

Pectobacterium_phage(25.0%)

transposase,tail,plate

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014058516.1\|6282178_6286129_-\|plate	putative baseplate assembly protein	NA	NA	NA	NA
WP_014058517.1\|6286125_6289329_-\|plate	putative baseplate assembly protein	A0A1L2CUU9	Pectobacterium_phage	8.3e-06	33.3
WP_014058518.1\|6289564_6289963_-	GPW/gp25 family protein	NA	NA	NA	NA
WP_014058519.1\|6289959_6290304_-	hypothetical protein	NA	NA	NA	NA
WP_014058520.1\|6290340_6290874_-\|plate	baseplate assembly protein	NA	NA	NA	NA
WP_014058521.1\|6290906_6292046_-	hypothetical protein	NA	NA	NA	NA
WP_014058522.1\|6292038_6292431_-	hypothetical protein	NA	NA	NA	NA
WP_014058523.1\|6292434_6293121_-	hypothetical protein	NA	NA	NA	NA
WP_014058524.1\|6293117_6293828_-	hypothetical protein	NA	NA	NA	NA
WP_014058525.1\|6293864_6300413_-	DUF4157 domain-containing protein	NA	NA	NA	NA
WP_014058526.1\|6300409_6300703_-	hypothetical protein	NA	NA	NA	NA
WP_106685958.1\|6300693_6302616_-	ATP-binding protein	A0A109WUE1	Acidianus_tailed_spindle_virus	5.7e-10	37.0
WP_014058528.1\|6303008_6303926_-	DUF4255 domain-containing protein	NA	NA	NA	NA
WP_014058529.1\|6303930_6304674_-	hypothetical protein	NA	NA	NA	NA
WP_014058530.1\|6304666_6305539_-	hypothetical protein	NA	NA	NA	NA
WP_014058531.1\|6305562_6306087_-\|tail	phage tail protein	NA	NA	NA	NA
WP_014058532.1\|6306094_6307942_-\|tail	phage tail sheath family protein	J9PVC2	Bacillus_phage	4.7e-46	36.1
WP_014058533.1\|6308629_6309910_-\|transposase	transposase	I4AZI9	Saccharomonospora_phage	3.5e-40	31.8

DBSCAN-SWA_5

6854331 : 6913626

Leptospira_phage(20.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_167543197.1\|6854331_6855378_+\|transposase	IS630 family transposase	S5VXX4	Leptospira_phage	3.3e-44	34.2
WP_014058959.1\|6855894_6856746_+	methyltransferase domain-containing protein	NA	NA	NA	NA
WP_014058960.1\|6856779_6857262_-	molybdopterin-dependent oxidoreductase	NA	NA	NA	NA
WP_014058961.1\|6857399_6858158_-	C4-dicarboxylate transporter/malic acid transporter	NA	NA	NA	NA
WP_150112924.1\|6858293_6858860_+	CGNR zinc finger domain-containing protein	NA	NA	NA	NA
WP_014058964.1\|6859258_6860596_-	aldehyde dehydrogenase family protein	NA	NA	NA	NA
WP_014058965.1\|6860849_6862946_-	hypothetical protein	NA	NA	NA	NA
WP_043236629.1\|6863880_6864474_+	DUF4291 domain-containing protein	NA	NA	NA	NA
WP_014058967.1\|6864822_6865458_+	hypothetical protein	NA	NA	NA	NA
WP_014058968.1\|6865667_6866939_+\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	1.0e-31	35.8
WP_014058970.1\|6867185_6868268_-\|transposase	transposase	NA	NA	NA	NA
WP_043236631.1\|6868820_6869486_+	response regulator transcription factor	NA	NA	NA	NA
WP_014058972.1\|6869495_6870737_-	two-component sensor histidine kinase	NA	NA	NA	NA
WP_014058973.1\|6871132_6871507_+	SDR family oxidoreductase	NA	NA	NA	NA
WP_014058974.1\|6871666_6873889_+	MMPL family transporter	NA	NA	NA	NA
WP_014058975.1\|6874036_6874324_+\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_167543187.1\|6875774_6876272_-	hypothetical protein	NA	NA	NA	NA
WP_014058978.1\|6877710_6878109_-	hypothetical protein	NA	NA	NA	NA
WP_014058979.1\|6878105_6878954_-\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_014058980.1\|6879093_6880560_-	HAMP domain-containing histidine kinase	NA	NA	NA	NA
WP_014058981.1\|6880556_6881303_-	response regulator transcription factor	NA	NA	NA	NA
WP_014058982.1\|6881393_6881999_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_014058983.1\|6885485_6886400_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_014058984.1\|6886546_6886756_+	hypothetical protein	NA	NA	NA	NA
WP_014058985.1\|6887279_6889598_+	5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase	NA	NA	NA	NA
WP_014058986.1\|6889680_6890628_-	AraC family transcriptional regulator	NA	NA	NA	NA
WP_014058987.1\|6890732_6891716_+	NAD(P)-dependent alcohol dehydrogenase	NA	NA	NA	NA
WP_014058989.1\|6892754_6893609_-	alpha/beta fold hydrolase	NA	NA	NA	NA
WP_014058990.1\|6893648_6894893_-	epoxide hydrolase	NA	NA	NA	NA
WP_043239999.1\|6894889_6895780_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_014058992.1\|6895831_6896896_-	alkene reductase	NA	NA	NA	NA
WP_014058993.1\|6897030_6897513_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_014058994.1\|6897515_6897956_-	Lrp/AsnC family transcriptional regulator	NA	NA	NA	NA
WP_014058995.1\|6898156_6899296_+	acyl-CoA dehydrogenase	NA	NA	NA	NA
WP_014058996.1\|6899312_6900002_-	SDR family NAD(P)-dependent oxidoreductase	Q56AQ6	Bacillus_thuringiensis_phage	8.0e-07	28.8
WP_014058997.1\|6899998_6900895_-	NAD(P)H-binding protein	NA	NA	NA	NA
WP_014058998.1\|6900963_6901773_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_150112925.1\|6901901_6902474_+	hypothetical protein	NA	NA	NA	NA
WP_014059000.1\|6903077_6903902_-	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	2.0e-68	48.1
WP_014059001.1\|6903955_6904381_-	heme-binding protein	NA	NA	NA	NA
WP_014059002.1\|6904431_6905637_-	MFS transporter	NA	NA	NA	NA
WP_014059003.1\|6905800_6906304_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_014059004.1\|6906306_6907245_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_014059005.1\|6907385_6908396_+	aldo/keto reductase	NA	NA	NA	NA
WP_014059006.1\|6908434_6908863_+	SRPBCC family protein	NA	NA	NA	NA
WP_078505832.1\|6909095_6909683_-	substrate-binding domain-containing protein	NA	NA	NA	NA
WP_014059007.1\|6910455_6911892_-	3-(3-hydroxyphenyl)propionate hydroxylase	NA	NA	NA	NA
WP_043236640.1\|6912007_6912973_+	Lrp/AsnC family transcriptional regulator	NA	NA	NA	NA
WP_014059009.1\|6913122_6913626_+\|transposase	transposase	A0A1B3AZF8	Gordonia_phage	2.4e-08	40.4

DBSCAN-SWA_6

7216404 : 7286969

Bacillus_phage(36.36%)

protease,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014059259.1\|7216404_7217319_+\|transposase	IS982 family transposase	NA	NA	NA	NA
WP_014059260.1\|7217410_7218073_-	DUF4232 domain-containing protein	NA	NA	NA	NA
WP_014059261.1\|7218383_7219772_-	M1 family metallopeptidase	A0A0P0IY26	Acinetobacter_phage	1.6e-14	24.3
WP_014059262.1\|7219768_7223764_-	non-ribosomal peptide synthetase	A0A2K9L3I8	Tupanvirus	4.6e-30	23.3
WP_014059263.1\|7224525_7225017_+	DUF2975 domain-containing protein	NA	NA	NA	NA
WP_014059264.1\|7225016_7225238_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_014059265.1\|7225674_7226067_-	SnoaL-like domain-containing protein	NA	NA	NA	NA
WP_014059266.1\|7226194_7226875_-	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_043236703.1\|7226977_7227814_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_014059268.1\|7227937_7229113_-	epoxide hydrolase	NA	NA	NA	NA
WP_014059269.1\|7229195_7229771_+	CGNR zinc finger domain-containing protein	NA	NA	NA	NA
WP_043240182.1\|7231341_7231755_-	LLM class flavin-dependent oxidoreductase	NA	NA	NA	NA
WP_106685737.1\|7232454_7235850_+	protein kinase	NA	NA	NA	NA
WP_014059271.1\|7235960_7237328_+	protein kinase	K7YWY9	Megavirus	6.5e-08	26.5
WP_014059272.1\|7237610_7238546_-	M56 family metallopeptidase	NA	NA	NA	NA
WP_014059273.1\|7238561_7238939_-	penicillinase repressor	NA	NA	NA	NA
WP_106685975.1\|7239045_7239663_+	hypothetical protein	NA	NA	NA	NA
WP_014059275.1\|7239659_7240877_+	glycosyltransferase family 4 protein	NA	NA	NA	NA
WP_014059276.1\|7240971_7241808_+	undecaprenyl-diphosphate phosphatase	NA	NA	NA	NA
WP_014059277.1\|7241804_7243250_+	hypothetical protein	NA	NA	NA	NA
WP_014059279.1\|7243863_7245066_-	AbrB family transcriptional regulator	NA	NA	NA	NA
WP_014059280.1\|7245304_7245982_+	response regulator transcription factor	W8CYM9	Bacillus_phage	2.8e-28	33.2
WP_014059281.1\|7245982_7247434_+	HAMP domain-containing protein	W8CYF6	Bacillus_phage	6.8e-16	28.0
WP_043236707.1\|7247596_7248430_+	membrane protein	NA	NA	NA	NA
WP_014059283.1\|7248490_7249876_-	HAMP domain-containing histidine kinase	NA	NA	NA	NA
WP_014059284.1\|7249872_7250535_-	response regulator transcription factor	W8CYM9	Bacillus_phage	1.6e-28	37.0
WP_014059285.1\|7250544_7251219_-	phosphatase PAP2 family protein	NA	NA	NA	NA
WP_014059286.1\|7251271_7251955_-	DedA family protein	NA	NA	NA	NA
WP_014059287.1\|7252076_7252448_+	hypothetical protein	NA	NA	NA	NA
WP_043240193.1\|7252459_7253389_+\|protease	M48 family metalloprotease	NA	NA	NA	NA
WP_014059290.1\|7253834_7254623_+	ABC transporter permease	NA	NA	NA	NA
WP_014059291.1\|7255123_7255405_+	hypothetical protein	NA	NA	NA	NA
WP_014059292.1\|7255646_7256174_+	carboxymuconolactone decarboxylase family protein	NA	NA	NA	NA
WP_043236713.1\|7256588_7256903_-	hypothetical protein	NA	NA	NA	NA
WP_014059293.1\|7257876_7258395_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_014059294.1\|7258469_7259858_-	tryptophanase	NA	NA	NA	NA
WP_014059295.1\|7259925_7260753_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_014059297.1\|7263106_7264042_-	aldo/keto reductase	NA	NA	NA	NA
WP_014059298.1\|7264863_7265514_-	hypothetical protein	NA	NA	NA	NA
WP_078505440.1\|7265669_7266197_+	hypothetical protein	NA	NA	NA	NA
WP_014059299.1\|7266269_7267169_-	glycoside hydrolase family 16 protein	NA	NA	NA	NA
WP_106685740.1\|7267864_7268581_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_014059301.1\|7268579_7269533_+	NADP-dependent oxidoreductase	NA	NA	NA	NA
WP_106685976.1\|7270390_7270975_-\|transposase	transposase	NA	NA	NA	NA
WP_014059306.1\|7273590_7273803_+	type II toxin-antitoxin system VapB family antitoxin	NA	NA	NA	NA
WP_014059307.1\|7273799_7274219_+	PIN domain nuclease	NA	NA	NA	NA
WP_014059308.1\|7275667_7277395_+	serine/threonine protein kinase	M1I9Q9	Paramecium_bursaria_Chlorella_virus	1.6e-08	26.0
WP_050993785.1\|7277382_7279638_+	PQQ-binding-like beta-propeller repeat protein	A0A0B5J6A8	Pandoravirus	4.2e-12	36.7
WP_014059311.1\|7281265_7282819_+	hypothetical protein	NA	NA	NA	NA
WP_014059314.1\|7284687_7284840_-	hypothetical protein	NA	NA	NA	NA
WP_014059315.1\|7284836_7285109_-	hypothetical protein	NA	NA	NA	NA
WP_014059316.1\|7285740_7286049_+\|transposase	transposase	A0A1B3AZF8	Gordonia_phage	1.2e-18	52.9
WP_106685741.1\|7286045_7286366_+\|transposase	IS3 family transposase	A0A1P8CWQ3	Bacillus_phage	3.4e-08	38.2
WP_106685742.1\|7286696_7286969_+\|transposase	IS3 family transposase	Q8W6R2	Burkholderia_virus	4.1e-07	39.5

DBSCAN-SWA_7

7290849 : 7355656

Pandoravirus(25.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_167543215.1\|7290849_7292460_-\|transposase	IS1182 family transposase	NA	NA	NA	NA
WP_106685743.1\|7292631_7292880_-\|transposase	transposase	NA	NA	NA	NA
WP_106685744.1\|7292876_7293518_-\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_043236735.1\|7293716_7294280_-	hypothetical protein	NA	NA	NA	NA
WP_014059320.1\|7294462_7295413_-	alpha/beta hydrolase	A0A0B5J003	Pandoravirus	3.2e-14	31.8
WP_014059321.1\|7295870_7296230_-	nuclear transport factor 2 family protein	NA	NA	NA	NA
WP_043236737.1\|7297364_7298234_+	MerR family transcriptional regulator	NA	NA	NA	NA
WP_014059323.1\|7298467_7299304_-	serine hydrolase	NA	NA	NA	NA
WP_014059324.1\|7299312_7299732_-	DUF393 domain-containing protein	NA	NA	NA	NA
WP_043236739.1\|7300120_7300954_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_106685745.1\|7301138_7301549_+	SnoaL-like domain-containing protein	NA	NA	NA	NA
WP_014059327.1\|7301545_7302400_+	NAD(P)H-binding protein	NA	NA	NA	NA
WP_014059329.1\|7303911_7304184_-	hypothetical protein	NA	NA	NA	NA
WP_014059330.1\|7304817_7305213_-	DUF2267 domain-containing protein	NA	NA	NA	NA
WP_014059331.1\|7305528_7306161_+	MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_043236741.1\|7306440_7307565_-\|transposase	transposase	NA	NA	NA	NA
WP_014059333.1\|7308939_7309644_-	TetR family transcriptional regulator	NA	NA	NA	NA
WP_014059334.1\|7309754_7310237_+	SRPBCC domain-containing protein	NA	NA	NA	NA
WP_014059335.1\|7310380_7311478_+\|transposase	transposase	NA	NA	NA	NA
WP_123060311.1\|7312432_7312645_-\|transposase	Tn3 family transposase	NA	NA	NA	NA
WP_014059337.1\|7312885_7313302_-	SnoaL-like domain-containing protein	NA	NA	NA	NA
WP_014059338.1\|7313416_7313869_-	VOC family protein	NA	NA	NA	NA
WP_014059339.1\|7313967_7314945_+	Lrp/AsnC family transcriptional regulator	NA	NA	NA	NA
WP_043236745.1\|7315613_7315949_+	hypothetical protein	NA	NA	NA	NA
WP_167543234.1\|7315915_7316527_+	hypothetical protein	NA	NA	NA	NA
WP_043240255.1\|7316780_7317077_+	DUF1330 domain-containing protein	NA	NA	NA	NA
WP_167543235.1\|7319321_7320245_+\|transposase	IS701 family transposase	NA	NA	NA	NA
WP_014059344.1\|7321519_7322287_+	hypothetical protein	NA	NA	NA	NA
WP_150112929.1\|7322381_7323074_-	hypothetical protein	NA	NA	NA	NA
WP_014059347.1\|7324025_7324433_+	hypothetical protein	NA	NA	NA	NA
WP_150112930.1\|7325338_7325650_+	hypothetical protein	NA	NA	NA	NA
WP_014059348.1\|7325669_7326941_+\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	3.0e-31	35.2
WP_106685748.1\|7327121_7328465_-	MFS transporter	NA	NA	NA	NA
WP_014059351.1\|7330398_7331325_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_167543236.1\|7331468_7331666_+	hypothetical protein	NA	NA	NA	NA
WP_014059352.1\|7332019_7333420_-	PLP-dependent aminotransferase family protein	NA	NA	NA	NA
WP_014059353.1\|7333513_7334656_+	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_014059354.1\|7335119_7335995_-	cyclase family protein	NA	NA	NA	NA
WP_014059355.1\|7337392_7337740_+	hypothetical protein	NA	NA	NA	NA
WP_014059356.1\|7337736_7337997_+	hypothetical protein	NA	NA	NA	NA
WP_014059357.1\|7338509_7338914_+	hypothetical protein	NA	NA	NA	NA
WP_106685749.1\|7340257_7340647_-	zinc-binding dehydrogenase	NA	NA	NA	NA
WP_014059360.1\|7343554_7343980_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_014059361.1\|7344075_7345071_+	superoxide dismutase	NA	NA	NA	NA
WP_014059363.1\|7345222_7346089_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_043236761.1\|7347401_7348100_-	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_014059366.1\|7348268_7349198_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_167543237.1\|7349861_7349999_-	hypothetical protein	NA	NA	NA	NA
WP_014059367.1\|7350071_7351214_-	NAD(P)-binding protein	NA	NA	NA	NA
WP_014059368.1\|7351384_7351720_+	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_106685751.1\|7354427_7355198_-\|transposase	IS3 family transposase	Q8W6R2	Burkholderia_virus	9.5e-41	41.2
WP_014043695.1\|7355347_7355656_-\|transposase	transposase	A0A1B3AZF8	Gordonia_phage	2.6e-18	52.9

DBSCAN-SWA_8

7366304 : 7400314

Mycobacterium_phage(60.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014054022.1\|7366304_7367576_+\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	1.0e-31	35.8
WP_150112931.1\|7368414_7369407_-	hypothetical protein	NA	NA	NA	NA
WP_167543238.1\|7369439_7370078_-	ABC transporter permease subunit	NA	NA	NA	NA
WP_123060295.1\|7370218_7370605_-\|transposase	transposase	NA	NA	NA	NA
WP_014059382.1\|7370950_7371646_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_014059383.1\|7371747_7372752_-	quinone oxidoreductase	NA	NA	NA	NA
WP_014059384.1\|7372801_7373383_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_014059386.1\|7374838_7375456_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_014059387.1\|7375550_7376984_+	MFS transporter	NA	NA	NA	NA
WP_014059388.1\|7376980_7378264_+	serine hydrolase	A0A1J0GRK9	Mycobacterium_phage	2.2e-05	25.6
WP_078505458.1\|7378253_7379465_+	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_014059390.1\|7379461_7380502_+	membrane dipeptidase	NA	NA	NA	NA
WP_014059391.1\|7380512_7381427_+	ornithine cyclodeaminase family protein	NA	NA	NA	NA
WP_014059392.1\|7381719_7382565_+\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_150112932.1\|7382615_7384196_+	phosphate ABC transporter substrate-binding protein, PhoT family	NA	NA	NA	NA
WP_014059395.1\|7384649_7385762_-\|transposase	transposase	NA	NA	NA	NA
WP_078505460.1\|7385763_7386612_+\|transposase	transposase	NA	NA	NA	NA
WP_014059396.1\|7386782_7389260_-	XRE family transcriptional regulator	NA	NA	NA	NA
WP_014059397.1\|7389613_7390840_+	serine hydrolase	A0A2K9VHZ2	Mycobacterium_phage	1.6e-21	29.1
WP_014059398.1\|7390956_7392174_+	serine hydrolase	A0A2P1JQM9	Mycobacterium_phage	3.7e-23	35.2
WP_014059399.1\|7395212_7395821_+	SDR family oxidoreductase	NA	NA	NA	NA
WP_014059400.1\|7395817_7396717_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_014059401.1\|7396770_7397562_+	inositol phosphatase	NA	NA	NA	NA
WP_167543197.1\|7397796_7398843_-\|transposase	IS630 family transposase	S5VXX4	Leptospira_phage	3.3e-44	34.2
WP_014059403.1\|7399096_7400314_-\|transposase	ISAs1 family transposase	NA	NA	NA	NA

DBSCAN-SWA_9

7435242 : 7572185

Burkholderia_virus(22.22%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_106685978.1\|7435242_7435614_-\|transposase	transposase	NA	NA	NA	NA
WP_014059434.1\|7435710_7436802_+\|transposase	transposase	NA	NA	NA	NA
WP_078505466.1\|7436834_7437155_-	Lsr2 family protein	NA	NA	NA	NA
WP_014059436.1\|7438473_7438824_+	SseB family protein	NA	NA	NA	NA
WP_043236793.1\|7438810_7439365_+	hypothetical protein	NA	NA	NA	NA
WP_014059438.1\|7439361_7443909_+	type IV secretion protein Rhs	NA	NA	NA	NA
WP_043240316.1\|7443922_7444678_+	hypothetical protein	NA	NA	NA	NA
WP_043240320.1\|7445775_7446864_+\|transposase	transposase	NA	NA	NA	NA
WP_014059443.1\|7447250_7448081_-	AfsR/SARP family transcriptional regulator	NA	NA	NA	NA
WP_014043695.1\|7449861_7450170_+\|transposase	transposase	A0A1B3AZF8	Gordonia_phage	2.6e-18	52.9
WP_106685742.1\|7450816_7451089_+\|transposase	IS3 family transposase	Q8W6R2	Burkholderia_virus	4.1e-07	39.5
WP_078505468.1\|7451085_7452225_-	RNA-directed DNA polymerase	NA	NA	NA	NA
WP_167543240.1\|7452118_7452547_+\|transposase	transposase	Q8W6R2	Burkholderia_virus	6.0e-37	56.1
WP_014059446.1\|7453272_7456038_-	LuxR family transcriptional regulator	NA	NA	NA	NA
WP_014059449.1\|7477923_7496430_-	type I polyketide synthase	NA	NA	NA	NA
WP_014059450.1\|7497018_7497927_-	alpha/beta hydrolase	M1PGN2	Moumouvirus	1.7e-28	34.3
WP_014059451.1\|7498742_7499753_+	hypothetical protein	NA	NA	NA	NA
WP_014059452.1\|7499833_7501354_+	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_014059453.1\|7502857_7503679_-	mycofactocin-coupled SDR family oxidoreductase	NA	NA	NA	NA
WP_014059454.1\|7503750_7505202_-	aldehyde dehydrogenase	NA	NA	NA	NA
WP_014059455.1\|7505272_7506376_-	NAD(P)-dependent alcohol dehydrogenase	A0A0K0KVL7	Prochlorococcus_phage	1.8e-21	26.2
WP_014059456.1\|7506372_7517418_-	type I polyketide synthase	D0R7J2	Paenibacillus_phage	5.2e-31	28.5
WP_078505471.1\|7517446_7533061_-	type I polyketide synthase	D0R7J2	Paenibacillus_phage	1.8e-29	28.3
WP_014059458.1\|7534085_7535789_-\|transposase	IS1182 family transposase	NA	NA	NA	NA
WP_014059459.1\|7535965_7536781_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_043236799.1\|7536883_7537732_+	SDR family oxidoreductase	NA	NA	NA	NA
WP_150112935.1\|7537791_7539189_+	carboxylesterase family protein	NA	NA	NA	NA
WP_014059462.1\|7539958_7541134_+	hypothetical protein	NA	NA	NA	NA
WP_078505472.1\|7541304_7541877_+\|transposase	transposase	NA	NA	NA	NA
WP_014059463.1\|7542285_7542498_+	hypothetical protein	NA	NA	NA	NA
WP_014059464.1\|7542950_7543301_+	hypothetical protein	NA	NA	NA	NA
WP_014059466.1\|7543593_7545669_-	glycosyl hydrolase	NA	NA	NA	NA
WP_043236804.1\|7546099_7546888_+	GntR family transcriptional regulator	NA	NA	NA	NA
WP_014059469.1\|7547087_7548383_+	D-tagatose-bisphosphate aldolase, class II, non-catalytic subunit	NA	NA	NA	NA
WP_014059470.1\|7548379_7549543_+	SIS domain-containing protein	NA	NA	NA	NA
WP_014059471.1\|7549592_7550585_+	N-acetylglucosamine kinase	NA	NA	NA	NA
WP_014059472.1\|7550581_7551532_+	DMT family transporter	NA	NA	NA	NA
WP_014059473.1\|7551627_7552479_+	ketose-bisphosphate aldolase	NA	NA	NA	NA
WP_014059474.1\|7553224_7554310_+\|transposase	transposase	NA	NA	NA	NA
WP_167543241.1\|7554394_7554787_+	hypothetical protein	NA	NA	NA	NA
WP_014059475.1\|7556394_7557633_+	serine/threonine-protein phosphatase	NA	NA	NA	NA
WP_014059477.1\|7559163_7559949_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_014059478.1\|7560156_7561035_+	NmrA/HSCARG family protein	NA	NA	NA	NA
WP_014059479.1\|7561090_7561993_+	NADP-dependent oxidoreductase	NA	NA	NA	NA
WP_014059481.1\|7562782_7564189_-\|transposase	IS1380 family transposase	A0A222ZN33	Mycobacterium_phage	1.9e-87	43.9
WP_043236810.1\|7564420_7565422_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_014059483.1\|7567635_7568397_-	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_014059484.1\|7568587_7569460_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_014054022.1\|7569621_7570893_-\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	1.0e-31	35.8
WP_014059485.1\|7571096_7572185_-\|transposase	transposase	NA	NA	NA	NA

DBSCAN-SWA_10

8773338 : 8806108

Gordonia_phage(14.29%)

capsid,integrase,portal,head,protease,transposase,terminase

attL 8773569:8773586|attR 8810409:8810426

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014043695.1\|8773338_8773647_+\|transposase	transposase	A0A1B3AZF8	Gordonia_phage	2.6e-18	52.9
8773569:8773586	attL	NA	NA	NA	NA
WP_014043694.1\|8773643_8774564_+\|transposase	IS3 family transposase	Q8W6R2	Burkholderia_virus	2.4e-43	38.7
WP_050993834.1\|8774751_8775387_+	hypothetical protein	NA	NA	NA	NA
WP_014060510.1\|8775500_8776100_+	hypothetical protein	NA	NA	NA	NA
WP_014060511.1\|8776096_8776288_+	hypothetical protein	NA	NA	NA	NA
WP_014060512.1\|8776382_8776679_+	putative ATP-grasp-modified RiPP	NA	NA	NA	NA
WP_014060513.1\|8776678_8777644_+	ATP-grasp ribosomal peptide maturase	S5VKI3	Leptospira_phage	1.8e-28	28.9
WP_014060514.1\|8777643_8778774_+	protein-L-isoaspartate O-methyltransferase	NA	NA	NA	NA
WP_014060515.1\|8778848_8779166_+	hypothetical protein	NA	NA	NA	NA
WP_014060516.1\|8779398_8780595_+	helix-turn-helix transcriptional regulator	A0A1J0MCE6	Streptomyces_phage	3.4e-29	29.1
WP_014060517.1\|8780697_8781297_+	hypothetical protein	NA	NA	NA	NA
WP_014060518.1\|8781293_8781485_+	hypothetical protein	NA	NA	NA	NA
WP_014060519.1\|8781692_8782781_+	methyltransferase domain-containing protein	A0A1J0MC37	Streptomyces_phage	1.7e-59	39.2
WP_106685778.1\|8782867_8784160_-\|integrase	site-specific integrase	A0A160DFH7	Gordonia_phage	1.8e-20	26.6
WP_014060522.1\|8785100_8785316_+	excisionase family DNA-binding protein	NA	NA	NA	NA
WP_106686002.1\|8785855_8788168_+	DUF3987 domain-containing protein	A0A2I6UGE7	Salinibacter_virus	1.3e-29	38.1
WP_014060525.1\|8788248_8788671_+	hypothetical protein	NA	NA	NA	NA
WP_014060526.1\|8788657_8788849_+	hypothetical protein	NA	NA	NA	NA
WP_014060527.1\|8788845_8789298_+	hypothetical protein	NA	NA	NA	NA
WP_014060528.1\|8789404_8789596_+	hypothetical protein	NA	NA	NA	NA
WP_014060529.1\|8789639_8790152_+	single-stranded DNA-binding protein	A0A222ZFS3	Arthrobacter_phage	5.5e-45	59.3
WP_014060530.1\|8790206_8790383_+	hypothetical protein	NA	NA	NA	NA
WP_106685779.1\|8790573_8791002_+	hypothetical protein	NA	NA	NA	NA
WP_043237074.1\|8791202_8791997_+	phosphotransferase	NA	NA	NA	NA
WP_014060533.1\|8792052_8793555_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_014060534.1\|8794130_8794619_+	hypothetical protein	NA	NA	NA	NA
WP_014060535.1\|8794615_8794930_+	hypothetical protein	NA	NA	NA	NA
WP_014060536.1\|8794926_8795130_+	hypothetical protein	NA	NA	NA	NA
WP_014060537.1\|8795126_8795330_+	hypothetical protein	NA	NA	NA	NA
WP_106686003.1\|8795392_8795641_+	endonuclease	NA	NA	NA	NA
WP_014060539.1\|8795826_8796156_+	hypothetical protein	NA	NA	NA	NA
WP_014060540.1\|8796152_8796398_+	hypothetical protein	NA	NA	NA	NA
WP_014060542.1\|8796819_8797194_+	hypothetical protein	NA	NA	NA	NA
WP_014060543.1\|8797607_8797895_+	hypothetical protein	NA	NA	NA	NA
WP_014060544.1\|8797973_8798165_+	hypothetical protein	NA	NA	NA	NA
WP_043237080.1\|8799353_8799536_+	hypothetical protein	NA	NA	NA	NA
WP_014060546.1\|8799748_8800072_+	hypothetical protein	NA	NA	NA	NA
WP_014060547.1\|8800088_8800361_+	HNH endonuclease	A0A1L6BZD8	Pasteurella_phage	7.0e-07	52.7
WP_014060548.1\|8800365_8800803_+	hypothetical protein	A0A1D8EX78	Mycobacterium_phage	4.9e-26	44.8
WP_014060549.1\|8801186_8801423_+	hypothetical protein	NA	NA	NA	NA
WP_106686004.1\|8801457_8802891_+\|terminase	terminase	G9FHH3	Rhodococcus_phage	1.8e-85	39.5
WP_014060551.1\|8802902_8804054_+\|portal	phage portal protein	Q6JIM9	Burkholderia_virus	1.6e-28	28.6
WP_014060552.1\|8804050_8804800_+\|head,protease	HK97 family phage prohead protease	Q8SBP9	Clostridium_phage	1.6e-21	40.9
WP_014060553.1\|8804890_8806108_+\|capsid	phage major capsid protein	A0A2K9VGS3	Pontimonas_phage	2.0e-61	40.2
8810409:8810426	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr_ID: NC_015957.1|WP_014059314.1|7284687_7284840_-|hypothetical-protein

Click the colored protein region to show detailed information

Acr_ID: NC_015957.1|WP_014059315.1|7284836_7285109_-|hypothetical-protein

Click the colored protein region to show detailed information

Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NC_015957.1|WP_014059314.1|7284687_7284840_-|hypothetical-protein

7284687_7284840_-

50 aa aa

7216404-7286969

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NC_015957_15	Orphan	15.1\|7441590\|38\|NC_015957\|CRISPRCasFinder	7441590-7441627	38	7261452-7261489	2
NC_015957_15	Orphan	15.2\|7441653\|38\|NC_015957\|CRISPRCasFinder	7441653-7441690	38	7261515-7261552	0

1. spacer 15.1|7441590|38|NC_015957|CRISPRCasFinder matches to NC_015957 position: 7261452-7261489, mismatch: 2

ccagatcgccaccaacgctgctggcctcccagtcgcca	CRISPR spacer
ccaggtcgccaccaacgctgctggcctcccagccgcca	Protospacer
****.***************************.*****

2. spacer 15.2|7441653|38|NC_015957|CRISPRCasFinder matches to NC_015957 position: 7261515-7261552, mismatch: 0

gcacttccgccgaggccctcacggccaggtcacggccg	CRISPR spacer
gcacttccgccgaggccctcacggccaggtcacggccg	Protospacer
**************************************

NC_015957.1|WP_014059315.1|7284836_7285109_-|hypothetical-protein

7284836_7285109_-

90 aa aa

7216404-7286969

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NC_015957_15	Orphan	15.1\|7441590\|38\|NC_015957\|CRISPRCasFinder	7441590-7441627	38	7261452-7261489	2
NC_015957_15	Orphan	15.2\|7441653\|38\|NC_015957\|CRISPRCasFinder	7441653-7441690	38	7261515-7261552	0

1. spacer 15.1|7441590|38|NC_015957|CRISPRCasFinder matches to NC_015957 position: 7261452-7261489, mismatch: 2

ccagatcgccaccaacgctgctggcctcccagtcgcca	CRISPR spacer
ccaggtcgccaccaacgctgctggcctcccagccgcca	Protospacer
****.***************************.*****

2. spacer 15.2|7441653|38|NC_015957|CRISPRCasFinder matches to NC_015957 position: 7261515-7261552, mismatch: 0

gcacttccgccgaggccctcacggccaggtcacggccg	CRISPR spacer
gcacttccgccgaggccctcacggccaggtcacggccg	Protospacer
**************************************

2. NC_015951

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NC_015951_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015951_1

104606-104878

TypeI-E

Consensus_repeat	Method
CGGCTCACCTCCGCTCGCGCGGAGAGCAC	PILER-CR
CGGCTCACCTCCGCTCGCGCGGAGAGCAC	CRISPRCasFinder
CGGCTCACCTCCGCTCGCGCGGAGAGCAC	CRT

4 spacers

cas2,cas6e,cas5,cas7,cse2gr11,cas8e,cas3

The CRISPR arrays of NC_015951_1

>merge|NC_015951|1|104606-104878|PILER-CR,CRISPRCasFinder,CRT
CGGCTCACCTCCGCTCGCGCGGAGAGCACTACCGCGCCGTCACCGGGGCCACCCCGAACTGCGGCTCACCTCCGCTCGCGCGGAGAGCACCACATCGCGCTCGCGCCCCGCACGAGCAGCACCGGCTCACCTCCGCTCGCGCGGAGAGCACTTGTTCGCAGCACGGACGGCTTTGTTGAGTTCCGGCTCACCTCCGCTCGCGCGGAGAGCACTCCGCAGGTCGGCCCCGTGGTCAACGGTCAGACGGCTCACCTCCGCTCGCGCAGAGAGCAC

>NC_015951|1|1|104606-104878|PILER-CR
CGGCTCACCTCCGCTCGCGCGGAGAGCAC	TACCGCGCCGTCACCGGGGCCACCCCGAACTG
CGGCTCACCTCCGCTCGCGCGGAGAGCAC	CACATCGCGCTCGCGCCCCGCACGAGCAGCAC
CGGCTCACCTCCGCTCGCGCGGAGAGCAC	TTGTTCGCAGCACGGACGGCTTTGTTGAGTTC
CGGCTCACCTCCGCTCGCGCGGAGAGCAC	TCCGCAGGTCGGCCCCGTGGTCAACGGTCAGA
CGGCTCACCTCCGCTCGCGCAGAGAGCAC

>NC_015951|1|1|104606-104878|CRISPRCasFinder
CGGCTCACCTCCGCTCGCGCGGAGAGCAC	TACCGCGCCGTCACCGGGGCCACCCCGAACTG
CGGCTCACCTCCGCTCGCGCGGAGAGCAC	CACATCGCGCTCGCGCCCCGCACGAGCAGCAC
CGGCTCACCTCCGCTCGCGCGGAGAGCAC	TTGTTCGCAGCACGGACGGCTTTGTTGAGTTC
CGGCTCACCTCCGCTCGCGCGGAGAGCAC	TCCGCAGGTCGGCCCCGTGGTCAACGGTCAGA
CGGCTCACCTCCGCTCGCGCAGAGAGCAC

>NC_015951|1|1|104606-104878|CRT
CGGCTCACCTCCGCTCGCGCGGAGAGCAC	TACCGCGCCGTCACCGGGGCCACCCCGAACTG
CGGCTCACCTCCGCTCGCGCGGAGAGCAC	CACATCGCGCTCGCGCCCCGCACGAGCAGCAC
CGGCTCACCTCCGCTCGCGCGGAGAGCAC	TTGTTCGCAGCACGGACGGCTTTGTTGAGTTC
CGGCTCACCTCCGCTCGCGCGGAGAGCAC	TCCGCAGGTCGGCCCCGTGGTCAACGGTCAGA
CGGCTCACCTCCGCTCGCGCAGAGAGCAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015951.1\|WP_014043537.1\|110126_111302_-\|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	cas7	pfam09344_cas7_CAS-I-E	gnl\|CDD\|378153
NC_015951.1\|WP_014043532.1\|100514_101747_+\|hypothetical-protein	unknown	unknown	unknown
NC_015951.1\|WP_063644483.1\|114015_116835_-\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|182031
NC_015951.1\|WP_043242267.1\|98958_99411_+\|hypothetical-protein	unknown	unknown	unknown
NC_015951.1\|WP_014043535.1\|108625_109270_-\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	cas6e	cd09727_cas6e_CAS-I-E	gnl\|CDD\|187858
NC_015951.1\|WP_078505979.1\|107359_107692_-\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	cas2	pfam09707_cas2_CAS-I-E	gnl\|CDD\|378244
NC_015951.1\|WP_014043526.1\|92180_92573_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226180
NC_015951.1\|WP_014043541.1\|117785_118340_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NC_015951.1\|WP_106686061.1\|111458_112052_-\|type-I-E-CRISPR-associated-protein-Cse2/CasB	cse2gr11	pfam09485_cse2gr11_CAS-I-E	gnl\|CDD\|378191
NC_015951.1\|WP_014043539.1\|112147_113758_-\|type-I-E-CRISPR-associated-protein-Cse1/CasA	cas8e	cd09729_cas8e_CAS-I-E	gnl\|CDD\|187860
NC_015951.1\|WP_150112973.1\|89592_90633_+\|hypothetical-protein	unknown	unknown	unknown
NC_015951.1\|WP_014043536.1\|109266_110130_-\|type-I-E-CRISPR-associated-protein-Cas5/CasD	cas5	cd09756_cas5_CAS-I-E	gnl\|CDD\|273842
NC_015951.1\|WP_014043533.1\|104100_104304_-\|hypothetical-protein	unknown	unknown	unknown
NC_015951.1\|WP_014043534.1\|104999_106613_-\|ISL3-family-transposase	unknown	unknown	gnl\|CDD\|225995
NC_015951.1\|WP_014043529.1\|94956_95286_+\|hypothetical-protein	unknown	unknown	unknown
NC_015951.1\|WP_043242264.1\|92569_92848_-\|hypothetical-protein	unknown	unknown	unknown
NC_015951.1\|WP_014043528.1\|93199_93643_+\|hypothetical-protein	unknown	unknown	unknown
NC_015951.1\|WP_014043542.1\|118450_119407_+\|NADP-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|176191
NC_015951.1\|WP_014043530.1\|95384_98765_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|223533
NC_015951.1\|WP_014043525.1\|90613_92026_+\|FAD-dependent-pyridine-nucleotide-disulfide-oxidoreductase	unknown	unknown	gnl\|CDD\|223717

Protein	Function_ID	Function_description	E-value
NC_015951.1\|WP_063644483.1\|114015_116835_-\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|182031	PRK09694, PRK09694, CRISPR-associated helicase/endonuclease Cas3.	1.99047e-78
NC_015951.1\|WP_014043537.1\|110126_111302_-\|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	gnl\|CDD\|378153	pfam09344, Cas_CT1975, CT1975-like protein. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is represented by CT1975 of Chlorobium tepidum.	5.52102e-145
NC_015951.1\|WP_014043541.1\|117785_118340_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	3.99052e-09
NC_015951.1\|WP_014043542.1\|118450_119407_+\|NADP-dependent-oxidoreductase	gnl\|CDD\|176191	cd05289, MDR_like_2, alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases. Members identified as zinc-dependent alcohol dehydrogenases and quinone oxidoreductase. QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR actin the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	8.72636e-82
NC_015951.1\|WP_078505979.1\|107359_107692_-\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	gnl\|CDD\|378244	pfam09707, Cas_Cas2CT1978, CRISPR-associated protein (Cas_Cas2CT1978). This entry represents a minor branch of the Cas2 family of CRISPR-associated protein which are found in IPR003799. Cas proteins are found adjacent to a characteristic short, palindromic repeat cluster termed CRISPR, a probable mobile DNA element.	6.07646e-40
NC_015951.1\|WP_014043526.1\|92180_92573_-\|hypothetical-protein	gnl\|CDD\|226180	COG3654, Doc, Prophage maintenance system killer protein [General function prediction only].	0.000449134
NC_015951.1\|WP_106686061.1\|111458_112052_-\|type-I-E-CRISPR-associated-protein-Cse2/CasB	gnl\|CDD\|378191	pfam09485, CRISPR_Cse2, CRISPR-associated protein Cse2 (CRISPR_cse2). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family of proteins, represented by CT1973 from Chlorobaculum tepidum, is encoded by genes found in the CRISPR/Cas subtype Ecoli regions of many bacteria (most of which are mesophiles), and not in Archaea. It is designated Cse2.	5.89606e-20
NC_015951.1\|WP_014043539.1\|112147_113758_-\|type-I-E-CRISPR-associated-protein-Cse1/CasA	gnl\|CDD\|187860	cd09729, Cse1_I-E, CRISPR/Cas system-associated protein Cse1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Large proteins, some contain Zn-finger domain; subunit of the Cascade complex; signature gene for I-E subtype; also known as Cse1/CasA/YgcL family.	1.89168e-78
NC_015951.1\|WP_014043536.1\|109266_110130_-\|type-I-E-CRISPR-associated-protein-Cas5/CasD	gnl\|CDD\|273842	TIGR01868, hypothetical_protein, CRISPR-associated protein Cas5/CasD, subtype I-E/ECOLI. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is part of the ECOLI subtype CRISPR/Cas locus, and now characterized as part of the CASCADE complex of that system. It shares a small N-terminal homology region with members of several other CRISPR/Cas subtypes, and we view the families that share this region as being Cas5.	4.41967e-52
NC_015951.1\|WP_014043534.1\|104999_106613_-\|ISL3-family-transposase	gnl\|CDD\|225995	COG3464, COG3464, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	4.95984e-31
NC_015951.1\|WP_014043535.1\|108625_109270_-\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	gnl\|CDD\|187858	cd09727, Cas6_I-E, CRISPR/Cas system-associated RAMP superfamily protein Cas6e. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas6e is an endoribonuclease that generates crRNA; This family is specific for CRISPR/Cas system I-E subtype; Homologous to Cas6 (RAMP superfamily protein); Possesses double RRM/ferredoxin fold; also known as Cse3 family.	2.39855e-61
NC_015951.1\|WP_014043530.1\|95384_98765_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|223533	COG0457, NrfG, FOG: TPR repeat [General function prediction only].	8.65402e-14
NC_015951.1\|WP_014043525.1\|90613_92026_+\|FAD-dependent-pyridine-nucleotide-disulfide-oxidoreductase	gnl\|CDD\|223717	COG0644, FixC, Dehydrogenases (flavoproteins) [Energy production and conversion].	1.57168e-08

>NC_015951.1|WP_014043533.1|104100_104304_-|hypothetical-protein
MLAVNAAYHKPTVVVMARITPPADSNEPLALDHLGLAAEMVYDTDTIDVHIAKDRFGPAPRLTTVVW
>NC_015951.1|WP_014043532.1|100514_101747_+|hypothetical-protein
MEAANLASIAMQMISGLATSAGTSVGTAAGEEVSRLVRDRLRGSQEGRAALTQLDQEPGSPEAESQVRTILTRALADDPDFATRLETAATQNTLHAGRDMTVQTVSVSSSTVKGTINIGPLTITKSRGAYLALGAAVIALALLLALGTYGAVQVISINNSPSTPSPDPTTTPATPSTGSTTTPQAGSGPKLEPITTRNAAKAVMPDQSVLPAGWSAAGEPDVVTASEAKYPVDPDDPPLEGGIELTGPDYGITLQMDFFETAASASNRFNRYDIIAGWEIDQHSESLAMPKIGDDSMAFIDYTPSDHVAGMVAAARIGTITCQVAATDTVHPADHADEVFAFTRMCIQRAKQGQQRRTPEASWKPAPSHGHRLPCLGAGAGKGSRLVAGVVADPHRQCLEGADSLALMRR
>NC_015951.1|WP_043242267.1|98958_99411_+|hypothetical-protein
MRPVTPADWPEAPALDPRPDPQDLSGDDIDDGWSEQTLFQVIVSLMPGARAVLRWITDLGGTTSFDEVQQYFVSHPTTPIAPGKLGGTLTSIKAVQRRIGPTGSSRLLQRNERARLYHIDRPLIEGLRRAFAIADARPDLLRGEPTAPVT
>NC_015951.1|WP_014043530.1|95384_98765_+|tetratricopeptide-repeat-protein
MVAVDGDRPGSGYAIAGRLVLTSAHVSPEPGGTVRVFRPGREETWCGTVVWRGTPGGRDDAALVSMDPAWAGPRQPVRWGRTVTHRPGTPCETWGAANLVQRPGRAVDTVQLSGTLNPGDRFVGNRYVMSLAQHPPAPTGEGDSPWGGMSGAALFCGDLLAGVIASDPAGRAHAHLEAVPAYVLTHDPGFHAALTDHAPEANATLEPVEWQHLAEPAARTRLMNSPATLLQARRQIVPFRGRTTLLTDLDTWAQEDGFGAKLLHGPGGQGKTRLAQHLADTLTTRGWTALWLRADAPADTLADLSAAAVPLLVIVDYAETRSPQLTALLEAAAQHVGDSAFKVLLLARTAGDWWNDLHAATATAEDLLDGTKTIPLPALEPEPDDSRTQAYHQAVHSYAAHLPHVRGWQHHDWPTLAAPLTTGTPDGLNRPGLDTALTLHMTALADLLDTTTTTAATADAPTVEDRLLVHERRYWTTTATAHHLHPRLTTATLTDALAAAHLLGADTHDQADTLLRHVPALADQTTDRIHAVRRWIAALYPAPTPAQPWGTLQPDRLTEHFTGRHLLHNPTLAHHLAPTATEPQAARLLTLYSRAAAHPALCQLGPHLTTLCTDHAPTLAAPALDVATQTETPQPLIDALNHITDNPTTPPAHLQYLAERLPHTSYNLAPYAAHLTQHLTEHHRTHAHRDPTHLPDFASSLNDLSNRLGDLGRWEEALKAIEEAVEIRRGLARDRPDAFRPELAMSLNNLAVRLGKLGRWEEALKAIEEAVQVYRGLARDRPDAFRPELAMSLNNLAVRLGKLGRQEEALKAIEEAVQVYRGLARDRPDAFRPELAMSLNNLAVRLGKLGRQEEALKAIEEAVQVYRGLARDRPDAFRPELAMSLNNLAVRLGDLGRQEEALKAIEEAVEIRRGLARDRPDAFRPDLASSSNNLAVQLGKLGRQEEALKAIEEAVQVYRGLARDRPDAFRPDLAMSLNNLAVRLGKLGRQEEALKAIEEAVQVYRGLARDRPDAFRPDLAMSSNNLAVRLGKLGRQEEALKAIEEAVEIRRGLARDRPDAFRPDLASSLNNLAVRLAELDRREEALKAIEEAVEIRRKLARDRPKIHQSELEHSLKVLDWLEESTG
>NC_015951.1|WP_014043529.1|94956_95286_+|hypothetical-protein
MEIELADAVAAVRDELLEAAARGAGQDLAFKVGPVELEFAVELRADAKAKTGFKAWVISADAEAGVTRGRTHRVTLTLTPQRPDGSDLLVHGAPSRQQGPGDVSGRIPD
>NC_015951.1|WP_014043528.1|93199_93643_+|hypothetical-protein
MLPDQDGQGWLLERRHVEALLALDSHPSLWALTMEQEDRYEGSAQKQDEREREQASRTLERIGEDEADRRAAAAADLHDGPTPDDPYALELQECPVCDYEAFSSDDGDELGMRVGTGECLVCHYRRSPAIANAIARQMEWERCWERD
>NC_015951.1|WP_043242264.1|92569_92848_-|hypothetical-protein
MSLRFPDPRQRAAIAAAAKNAGVSMQDYILSAAFERATAVEATFLEHFEASVARSHEAFAAEPSGIDPNSEQRAAEQEARRSLENHGQGHAA
>NC_015951.1|WP_014043526.1|92180_92573_-|hypothetical-protein
MSQPDPHQPPRLDVPFLLHAAERLPGDPQVDDLGPLYAAVERMYARVMERDIYGSSHLKAAALLQTLVKLPCLEHSNEAFAWHSAEAFLALNGHPLSYTPKNAVALVRDASAGSLGIARIARQLRDWTTT
>NC_015951.1|WP_014043525.1|90613_92026_+|FAD-dependent-pyridine-nucleotide-disulfide-oxidoreductase
MAPPINSTVPTPRRAVVLGASLTGMLAATVLADHADEVIVVDRDNLPNGPVRRPGLPQARHVHMLWSGGARAIEALVPGLEERWLAAGARRVHMPADLVALTAHGWTRRSPHTQYQIACTRDLLDAVAREHTLDRPGITVRTRTHADGLIGDQHQVRGVRLRHLETGAVTDLEACLVVDATGRGSRAPQWLSQLHLPPVREEIVDPGLVYATRVFRAPAGGENFPVVTFQADPSDGTPGRMATLAPIEGARWLVTLAGTRGAEPTARPEEFEPFARQLRHPLVADLIANAEPLTDVHITRACSNRRRFYEQMRSWPSGFIVLGDAVAAYNPVYGQGMSVAAQGATTLRHMIGKHGLQTTKLARHVQPAIGRLVQGPWNVTTGQDSQYPGAVGKQRPVAARLVHAYVVRLMRTANGRKAVTRALYDVMSLSAPSRRLFHPSVVLQVLLGPGQPPLTEPPLSPTERAYFSRP
>NC_015951.1|WP_150112973.1|89592_90633_+|hypothetical-protein
MDDLIGVTNLTLLLDRAMLTAISAIILTLIMYWRGGPKNTVVARTARWLLTTYAVIVVAEVILFILGDTPVETPLEFDTYYANTPYIRWMIALYLLAHGIAAIIATTLCWRWSAGLTEPLWLRRGLRVLTCGFLLNICFDITKITAVGARWDGTNWDFMNTTGAPVCATLCTTATTIGFILPLVGDRMSTARADLTTYRELHSLWKALRTATPDIAAPVPIPWWNLDLRLTRRITEIHDGRLALRAYRDPAVAADATEQARVADLAPDDANAVVEAAVLASAIRRKATSLKAPPVTTGPTTTATEVPLPRVALVQISRALQHSPIIAAACTLAPHQEISTHGPANQ
>NC_015951.1|WP_014043534.1|104999_106613_-|ISL3-family-transposase
MSDVEIGDVLFADLDGLQVDKVELSEDAVSVTARACAGEATCPACGTRSRRVHSCYQRRLADAAVGGRPVVVHLLVRRFRCPVASCPRTTFVEQIDGLTFRHGRRSQRLHTVLQMVALMLAGRGGARLAAVLSAAVSRSTLLRLIHALPDPSSVTPRVLGVDDFALRKGHIYGTVLIDVETRRPIDLLPDRESATLARWLSEHPGVEIICRDRASGYAEGARLGAPDAVQVADRWHLFHNLTEAVDRCVTRHSTRLRTPEPPPSPAMSTAPAAELEKISGAAKAERAAHRCADRTRDRHQEIHALIDKGLTLREISRELGLARNTVRKFARAATAEELSAGKWQGRASILDDYKPYLHQRWQEGCTSAKKLFEEIKAAGFRGGYSVVRDYLQPLRAGAKPADRAHRPPSVRDVTGWITRHPDSLTQDETLHLKDILARCPELDATAEHVRTFAEMMNARTGHKLAAWVDSVKAGKLPELVSFVNGIGCDLRAVEAGLTLPFSSGAVEGQVNRIKMLKRQMFGRAGLALLRKRVLLAA
>NC_015951.1|WP_078505979.1|107359_107692_-|type-I-E-CRISPR-associated-endoribonuclease-Cas2
MASMITIAASAVPDHLRGALTRWLLEVTPQLYVGTVSARVRDELWSTVTACTADGVAVLVYPADNEQGFELRTAGQQRRRPIDFEGLTLVAFGSLQPDPLSNSQGMANRF
>NC_015951.1|WP_014043535.1|108625_109270_-|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE
MTELWLTRIIPDLRSRQARRDLASAVGMHHRVMQLFPDTAAEQARAALGVLFRIEDGPQGPHLLIQSQAQPDTTALPVGYGTIATKPLTPLLDGLRAGRPVRYRIAASAVRKPGKTTRSLYNLKPIVPLTGAAADDWWIRQARQSGLTIHTVHSTPLDAARGEHAQGKHHIRHARTCFDGTATITDPGLLQRRLMEGIGRGKAYGCGLLTLAPA
>NC_015951.1|WP_014043536.1|109266_110130_-|type-I-E-CRISPR-associated-protein-Cas5/CasD
MTAPSAKPFLGLLLHLAGPLQSWGEHSRFNQRDTAPFPTKSGITGLLACALGRRRGETIEDLASMSLTIRSDRRGVLLRDLHTVGGGLPAKRTVTTAEGKKRPSSAATLLSHRYYLADAAFTAAITSDDHQLLQQCAAALKEPAWPLYLGRRSCPPHGPLLIGDGLFRNPLHHLVRLPLATASSSRHDDAAVEETAAIDFISDQPLDTLPGAPEAAGPHDGATPTGELNDHPLDFGPHQRTYRARAVYRRTLHLPATQRGGLGAAYLTQIHTYLNAYRDDLDQEADA
>NC_015951.1|WP_014043537.1|110126_111302_-|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC
MQRVVHAPGRFVDLHVLQSVPYANLNRDDTNSVKTVQYGNVERTRVSSQCWKRATRLYFERTLGQKALRTRRIGEAVAKDLRERCGWPEDLARRAGQHIAAGSSIKADPPDDDVPAWSTNAMVYVPGTAVTELADLAVQHREVLEAAPDMKKGGKSVLPKGDIDAVLRSRNGVINLLGRMLAEVDGAGVDGAVQVAHAMTTHATDVEVDYFSAVDDITAGWKDTAGSAHMGSTEHSAGVFYRYATVDLDDLLRNLDGDITAARELTSAFAEAFVLSLPQAKKNSTAPHTIPDLVHIGVRSDRPVSFAAAFEEPVTADRHGGYATASRQQLAAYAEAAHQLLGERGLLSSGWASLEDKDLTGLGERHSSFPELIHLSIDTALTPAVPAEAEA
>NC_015951.1|WP_106686061.1|111458_112052_-|type-I-E-CRISPR-associated-protein-Cse2/CasB
MLQLCAQDRGARAALRTGVGKHPDEARRMHRYVAVWLPSLDEDTQRAYYAVAALIAARRDTEAPNQTGRAEKAGKSPGSRFGESLGVAFAAAVARPRDGLRESSAEMRLNLLTRQSVAGIHRHLPAAVRQLCDKKTQPDWAQLVVDLRGWRDQRGRTGRRWLQDFYRARRQAEIAAAKDAAEQADATDADRPAAAAG
>NC_015951.1|WP_014043539.1|112147_113758_-|type-I-E-CRISPR-associated-protein-Cse1/CasA
MERTPPDEGYDLLEQRWIPVRWSAETLADAGGTAADAGEAAAEGGEELPAAVGLRELLERAHEIDALAVTVPPALAGLYRVLYALTARVTGLDRPGDDWSDRRYDVLDDGRLNPDRLWAYLSRYTDRFRLFDPVWPFLQDPRLAQQCEKAAGVNKLITTRPSGNNHAWFQHTRDAAPQAPAAAEAVLHLLVWRYWGPSGRCSSRTVGSVKAANVTAGPLRSALSYHPEGRTLFETLLAGVAEPDPDVRPEADLCPWEWEELPDPVQAPDMVRGPCSGLTARSQHALLLVPEPGGQTVRDAYISWAFLEKMPRDDDFLIWQTSKEGNRYPRLADAGRALWRDVDALLLEDPPGAARPRRPKVFRTAVEACEELRVRAVGFEQDGQAKDIQFVAACTPPLVGLLKQEDVPAAREVGRLRVWGETAGFRLATATRKAWALFTDASKAVECGWSQEAAARFWPRAEEEFWRRVRERDFDGAARGFRRIAEQVYEQVTYGAAGTARGARAREEARVELYGGRPKPAKKTAAAAGGGGGTAR
>NC_015951.1|WP_063644483.1|114015_116835_-|CRISPR-associated-helicase/endonuclease-Cas3
MDETPLPPAGIELDARLWGKEKGLLRPYPLICHLLDTAAIAGRLWDVMLGARSHGLIAERLGLGEDASRRWVCCWAGLHDLGKITPPFQSMSAGRYAVLAADEAYASAPGAEGERGLRHERATHWALTVLFAEWGYPHGPVSQSVAHQVAQLLGGHHGVFGCALEASKLRSPEVWEPGLGGPGWVGQRAVHAGVVRVLTGAGGVPSGRLSGEAAVVVSGVVVVADWLASQESVIAERLPADGWVGDGRELAAHWREAVEAAEWVVAGAGLGSAVFPVRSFAGQFPFSANALQESVERGLPGLVGERGSGLVLVTAPTGDGKTEAALHAASVLGRVSGAGGVFVALPTMATADAMVSRVEGFARVNVGGDRALVLLHSMAWLSRWGGSDQDDRGRVVADGVTALEAGEWLRGGRRGLLAPLGVGTVDQVLTGVLPVRFNVLRLLGLANKVLVVDEAHAYGPWMHMLLVRLLEWLGALSAPVVLLSATLSGRVASSLVEAYRRGCGFREPAVVEPCYPGWLFVDAASGGVSRPRAVGSDRPRTLRVVVEPVAWDVREPAGVPAAGSRRAALVEYLTPVVEQGGCVLVCCTTVDEAQRTFRFLRSVFPELAGEEGGLRLLHARFPAWRREEITGECERAFGKPGAEGVARPVCSVLVATQVVEQSLDLDFDLVVSDLAPLAQLLQRAGRCLRHERGGRPGWVGSDPWLVVLDPLGEEGVEPPRSWGEVYDVSLLVRTRRLLVERAGKGIAVPGDVQQVVDEVYAEDFGERLDQAAAEELRLRDARRVAGEAAETQLAKLTAIPSPYASSLRDLSLLSGAEGLVDEALVTTRLGADSERAVCVYEHAGGALTLDPEGRRELPGVDGRRLFRGQVAEVMRHTVPLPGRWLAGRDERHAALVAWSDRPVLASLVVLRFRLGADERWSCSVGDRSLLLDDLGVSER
>NC_015951.1|WP_014043541.1|117785_118340_-|TetR/AcrR-family-transcriptional-regulator
MRSPRADATRNRDQLLAVATRMFASADAEPSMRAIAREAGVGIATLYRHFPTRESLVDAVYRDQVVRLTTGARELLGQLPPGAAMRRWMDMFGDWIATKNGMLDTLLAMIESGEIAHAQTRTELLAAITTILDAGSAAGDLRSDVTAEDIAASLIGIFTVAPRPEREAKASRLLNLLMDGLRPA
>NC_015951.1|WP_014043542.1|118450_119407_+|NADP-dependent-oxidoreductase
MQEQRDQSPTDSSRAVRLESFGGPEVLDIRDIPAPQASPGQVRVRVTAAGLNPMDWFMTADADTAARFGLSLPAGFGTDYAGVVDQVGDGVTGFAPGDRVFGGALSRAVADFVVIEPAEGTAANEAHHTPGGVDDRTAATLTIAGRTASAALAVVDLGPDDTVLIGGAAGGVGVFAVQLARITGARVIGTGSATSAGFLRDLGAEPVAYGDGLADRVRTLAPSGVTAAIDLHGTETVHAARELGVPDGRICTIAAQVDGVPAANGANAAPGTLEGLARLVAAGQLRVPLAASFPIEQIRRAVELQADRHVKGKVVIDL

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Crispr_ID: NC_015951_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015951_2

106946-107342

TypeI-E

Consensus_repeat	Method
CGGCTCACCTCCGCTCGCGCGGAGAGCAC	PILER-CR
CGGCTCACCTCCGCTCGCGCGGAGAGCACC	CRISPRCasFinder
CGGCTCACCTCCGCTCGCGCGGAGAGCAC	CRT

6 spacers

cas2,cas6e,cas5,cas7,cse2gr11,cas8e,cas3

The CRISPR arrays of NC_015951_2

>merge|NC_015951|2|106946-107342|PILER-CR,CRISPRCasFinder,CRT
CGGCTCACCTCCGCTCGCGCGGAGAGCACCGACAGAAGATCGCCGACACCGCCCTGCGGCTCTGGCTCACCTCCGCTCGCGCAGAGAGCACACGAAAACAGCACCCGCCTGGGCGGTGGTGACCGGCTCACCTCCGCTCGCGCGGAGAGCACCTGTCCCATCCGCACATCGTCACCGTGCACGACGGCTCACCTCCGCTCGCGCGGAGAGCACCGGGACCAGGTCCGCTGGGCGAGGTCCCCGGCCGGCTCACCTCCGCTCGCGCGGAGAGCACTCGGGGGTCCACCGCTGGACGCCCTTGCCAGCCGGCTCACCTCCGCTCGCGCGGAGAGCACCATCAGCAAGATCCTGGAGACGCCCGACGGGGCGGCTCACCTCCGCTCGCGCGGAGAGCACC

>NC_015951|2|2|106946-107341|PILER-CR
CGGCTCACCTCCGCTCGCGCGGAGAGCAC	CGACAGAAGATCGCCGACACCGCCCTGCGGCTC
TGGCTCACCTCCGCTCGCGCAGAGAGCAC	ACGAAAACAGCACCCGCCTGGGCGGTGGTGAC
CGGCTCACCTCCGCTCGCGCGGAGAGCAC	CTGTCCCATCCGCACATCGTCACCGTGCACGA
CGGCTCACCTCCGCTCGCGCGGAGAGCAC	CGGGACCAGGTCCGCTGGGCGAGGTCCCCGGC
CGGCTCACCTCCGCTCGCGCGGAGAGCAC	TCGGGGGTCCACCGCTGGACGCCCTTGCCAGC
CGGCTCACCTCCGCTCGCGCGGAGAGCAC	CATCAGCAAGATCCTGGAGACGCCCGACGGGG
CGGCTCACCTCCGCTCGCGCGGAGAGCAC

>NC_015951|2|2|106946-107342|CRISPRCasFinder
CGGCTCACCTCCGCTCGCGCGGAGAGCACC	GACAGAAGATCGCCGACACCGCCCTGCGGCTC
TGGCTCACCTCCGCTCGCGCAGAGAGCACA	CGAAAACAGCACCCGCCTGGGCGGTGGTGAC
CGGCTCACCTCCGCTCGCGCGGAGAGCACC	TGTCCCATCCGCACATCGTCACCGTGCACGA
CGGCTCACCTCCGCTCGCGCGGAGAGCACC	GGGACCAGGTCCGCTGGGCGAGGTCCCCGGC
CGGCTCACCTCCGCTCGCGCGGAGAGCACT	CGGGGGTCCACCGCTGGACGCCCTTGCCAGC
CGGCTCACCTCCGCTCGCGCGGAGAGCACC	ATCAGCAAGATCCTGGAGACGCCCGACGGGG
CGGCTCACCTCCGCTCGCGCGGAGAGCACC

>NC_015951|2|2|106946-107341|CRT
CGGCTCACCTCCGCTCGCGCGGAGAGCAC	CGACAGAAGATCGCCGACACCGCCCTGCGGCTC
TGGCTCACCTCCGCTCGCGCAGAGAGCAC	ACGAAAACAGCACCCGCCTGGGCGGTGGTGAC
CGGCTCACCTCCGCTCGCGCGGAGAGCAC	CTGTCCCATCCGCACATCGTCACCGTGCACGA
CGGCTCACCTCCGCTCGCGCGGAGAGCAC	CGGGACCAGGTCCGCTGGGCGAGGTCCCCGGC
CGGCTCACCTCCGCTCGCGCGGAGAGCAC	TCGGGGGTCCACCGCTGGACGCCCTTGCCAGC
CGGCTCACCTCCGCTCGCGCGGAGAGCAC	CATCAGCAAGATCCTGGAGACGCCCGACGGGG
CGGCTCACCTCCGCTCGCGCGGAGAGCAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015951.1\|WP_014043537.1\|110126_111302_-\|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	cas7	pfam09344_cas7_CAS-I-E	gnl\|CDD\|378153
NC_015951.1\|WP_014043532.1\|100514_101747_+\|hypothetical-protein	unknown	unknown	unknown
NC_015951.1\|WP_063644483.1\|114015_116835_-\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|182031
NC_015951.1\|WP_043242267.1\|98958_99411_+\|hypothetical-protein	unknown	unknown	unknown
NC_015951.1\|WP_014043535.1\|108625_109270_-\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	cas6e	cd09727_cas6e_CAS-I-E	gnl\|CDD\|187858
NC_015951.1\|WP_078505979.1\|107359_107692_-\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	cas2	pfam09707_cas2_CAS-I-E	gnl\|CDD\|378244
NC_015951.1\|WP_014043526.1\|92180_92573_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226180
NC_015951.1\|WP_106686061.1\|111458_112052_-\|type-I-E-CRISPR-associated-protein-Cse2/CasB	cse2gr11	pfam09485_cse2gr11_CAS-I-E	gnl\|CDD\|378191
NC_015951.1\|WP_014043539.1\|112147_113758_-\|type-I-E-CRISPR-associated-protein-Cse1/CasA	cas8e	cd09729_cas8e_CAS-I-E	gnl\|CDD\|187860
NC_015951.1\|WP_014043541.1\|117785_118340_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NC_015951.1\|WP_014043536.1\|109266_110130_-\|type-I-E-CRISPR-associated-protein-Cas5/CasD	cas5	cd09756_cas5_CAS-I-E	gnl\|CDD\|273842
NC_015951.1\|WP_014043533.1\|104100_104304_-\|hypothetical-protein	unknown	unknown	unknown
NC_015951.1\|WP_014043534.1\|104999_106613_-\|ISL3-family-transposase	unknown	unknown	gnl\|CDD\|225995
NC_015951.1\|WP_014043529.1\|94956_95286_+\|hypothetical-protein	unknown	unknown	unknown
NC_015951.1\|WP_043242264.1\|92569_92848_-\|hypothetical-protein	unknown	unknown	unknown
NC_015951.1\|WP_014043528.1\|93199_93643_+\|hypothetical-protein	unknown	unknown	unknown
NC_015951.1\|WP_014043542.1\|118450_119407_+\|NADP-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|176191
NC_015951.1\|WP_014043530.1\|95384_98765_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|223533
NC_015951.1\|WP_014043543.1\|119637_120231_-\|M15-family-metallopeptidase	unknown	unknown	gnl\|CDD\|350618
NC_015951.1\|WP_014043525.1\|90613_92026_+\|FAD-dependent-pyridine-nucleotide-disulfide-oxidoreductase	unknown	unknown	gnl\|CDD\|223717

Protein	Function_ID	Function_description	E-value
NC_015951.1\|WP_063644483.1\|114015_116835_-\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|182031	PRK09694, PRK09694, CRISPR-associated helicase/endonuclease Cas3.	1.99047e-78
NC_015951.1\|WP_014043537.1\|110126_111302_-\|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	gnl\|CDD\|378153	pfam09344, Cas_CT1975, CT1975-like protein. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is represented by CT1975 of Chlorobium tepidum.	5.52102e-145
NC_015951.1\|WP_014043541.1\|117785_118340_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	3.99052e-09
NC_015951.1\|WP_014043542.1\|118450_119407_+\|NADP-dependent-oxidoreductase	gnl\|CDD\|176191	cd05289, MDR_like_2, alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases. Members identified as zinc-dependent alcohol dehydrogenases and quinone oxidoreductase. QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR actin the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	8.72636e-82
NC_015951.1\|WP_078505979.1\|107359_107692_-\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	gnl\|CDD\|378244	pfam09707, Cas_Cas2CT1978, CRISPR-associated protein (Cas_Cas2CT1978). This entry represents a minor branch of the Cas2 family of CRISPR-associated protein which are found in IPR003799. Cas proteins are found adjacent to a characteristic short, palindromic repeat cluster termed CRISPR, a probable mobile DNA element.	6.07646e-40
NC_015951.1\|WP_014043526.1\|92180_92573_-\|hypothetical-protein	gnl\|CDD\|226180	COG3654, Doc, Prophage maintenance system killer protein [General function prediction only].	0.000449134
NC_015951.1\|WP_106686061.1\|111458_112052_-\|type-I-E-CRISPR-associated-protein-Cse2/CasB	gnl\|CDD\|378191	pfam09485, CRISPR_Cse2, CRISPR-associated protein Cse2 (CRISPR_cse2). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family of proteins, represented by CT1973 from Chlorobaculum tepidum, is encoded by genes found in the CRISPR/Cas subtype Ecoli regions of many bacteria (most of which are mesophiles), and not in Archaea. It is designated Cse2.	5.89606e-20
NC_015951.1\|WP_014043539.1\|112147_113758_-\|type-I-E-CRISPR-associated-protein-Cse1/CasA	gnl\|CDD\|187860	cd09729, Cse1_I-E, CRISPR/Cas system-associated protein Cse1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Large proteins, some contain Zn-finger domain; subunit of the Cascade complex; signature gene for I-E subtype; also known as Cse1/CasA/YgcL family.	1.89168e-78
NC_015951.1\|WP_014043536.1\|109266_110130_-\|type-I-E-CRISPR-associated-protein-Cas5/CasD	gnl\|CDD\|273842	TIGR01868, hypothetical_protein, CRISPR-associated protein Cas5/CasD, subtype I-E/ECOLI. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is part of the ECOLI subtype CRISPR/Cas locus, and now characterized as part of the CASCADE complex of that system. It shares a small N-terminal homology region with members of several other CRISPR/Cas subtypes, and we view the families that share this region as being Cas5.	4.41967e-52
NC_015951.1\|WP_014043543.1\|119637_120231_-\|M15-family-metallopeptidase	gnl\|CDD\|350618	cd14843, D-Ala-D-Ala_dipeptidase_like, D-Ala-D-Ala dipeptidase, includes uncharacterized enzymes. This subfamily of D-Ala-D-Ala dipeptidase (also known as D-alanyl-D-alanine dipeptidase vanX; VanX; EC 3.4.13.22) also includes several uncharacterized proteins. This is a Zn2+-dependent enzyme that mediates resistance to the antibiotic vancomycin in Enterococci and other bacteria (both Gram-positive and Gram-negative). It is part of a gene cluster that affects cell-wall biosynthesis. The operon triggers the termination of peptidoglycan precursors by D-Ala-(R)-lactate instead of D-Ala-D-Ala dipeptides. The enzyme is stereospecific, as L-Ala-L-Ala, D-Ala-L-Ala and L-Ala-D-Ala are not substrates. It belongs in the MEROPS peptidase family M15, subfamily D.	1.24024e-62
NC_015951.1\|WP_014043534.1\|104999_106613_-\|ISL3-family-transposase	gnl\|CDD\|225995	COG3464, COG3464, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	4.95984e-31
NC_015951.1\|WP_014043535.1\|108625_109270_-\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	gnl\|CDD\|187858	cd09727, Cas6_I-E, CRISPR/Cas system-associated RAMP superfamily protein Cas6e. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas6e is an endoribonuclease that generates crRNA; This family is specific for CRISPR/Cas system I-E subtype; Homologous to Cas6 (RAMP superfamily protein); Possesses double RRM/ferredoxin fold; also known as Cse3 family.	2.39855e-61
NC_015951.1\|WP_014043530.1\|95384_98765_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|223533	COG0457, NrfG, FOG: TPR repeat [General function prediction only].	8.65402e-14
NC_015951.1\|WP_014043525.1\|90613_92026_+\|FAD-dependent-pyridine-nucleotide-disulfide-oxidoreductase	gnl\|CDD\|223717	COG0644, FixC, Dehydrogenases (flavoproteins) [Energy production and conversion].	1.57168e-08

>NC_015951.1|WP_014043534.1|104999_106613_-|ISL3-family-transposase
MSDVEIGDVLFADLDGLQVDKVELSEDAVSVTARACAGEATCPACGTRSRRVHSCYQRRLADAAVGGRPVVVHLLVRRFRCPVASCPRTTFVEQIDGLTFRHGRRSQRLHTVLQMVALMLAGRGGARLAAVLSAAVSRSTLLRLIHALPDPSSVTPRVLGVDDFALRKGHIYGTVLIDVETRRPIDLLPDRESATLARWLSEHPGVEIICRDRASGYAEGARLGAPDAVQVADRWHLFHNLTEAVDRCVTRHSTRLRTPEPPPSPAMSTAPAAELEKISGAAKAERAAHRCADRTRDRHQEIHALIDKGLTLREISRELGLARNTVRKFARAATAEELSAGKWQGRASILDDYKPYLHQRWQEGCTSAKKLFEEIKAAGFRGGYSVVRDYLQPLRAGAKPADRAHRPPSVRDVTGWITRHPDSLTQDETLHLKDILARCPELDATAEHVRTFAEMMNARTGHKLAAWVDSVKAGKLPELVSFVNGIGCDLRAVEAGLTLPFSSGAVEGQVNRIKMLKRQMFGRAGLALLRKRVLLAA
>NC_015951.1|WP_014043533.1|104100_104304_-|hypothetical-protein
MLAVNAAYHKPTVVVMARITPPADSNEPLALDHLGLAAEMVYDTDTIDVHIAKDRFGPAPRLTTVVW
>NC_015951.1|WP_014043532.1|100514_101747_+|hypothetical-protein
MEAANLASIAMQMISGLATSAGTSVGTAAGEEVSRLVRDRLRGSQEGRAALTQLDQEPGSPEAESQVRTILTRALADDPDFATRLETAATQNTLHAGRDMTVQTVSVSSSTVKGTINIGPLTITKSRGAYLALGAAVIALALLLALGTYGAVQVISINNSPSTPSPDPTTTPATPSTGSTTTPQAGSGPKLEPITTRNAAKAVMPDQSVLPAGWSAAGEPDVVTASEAKYPVDPDDPPLEGGIELTGPDYGITLQMDFFETAASASNRFNRYDIIAGWEIDQHSESLAMPKIGDDSMAFIDYTPSDHVAGMVAAARIGTITCQVAATDTVHPADHADEVFAFTRMCIQRAKQGQQRRTPEASWKPAPSHGHRLPCLGAGAGKGSRLVAGVVADPHRQCLEGADSLALMRR
>NC_015951.1|WP_043242267.1|98958_99411_+|hypothetical-protein
MRPVTPADWPEAPALDPRPDPQDLSGDDIDDGWSEQTLFQVIVSLMPGARAVLRWITDLGGTTSFDEVQQYFVSHPTTPIAPGKLGGTLTSIKAVQRRIGPTGSSRLLQRNERARLYHIDRPLIEGLRRAFAIADARPDLLRGEPTAPVT
>NC_015951.1|WP_014043530.1|95384_98765_+|tetratricopeptide-repeat-protein
MVAVDGDRPGSGYAIAGRLVLTSAHVSPEPGGTVRVFRPGREETWCGTVVWRGTPGGRDDAALVSMDPAWAGPRQPVRWGRTVTHRPGTPCETWGAANLVQRPGRAVDTVQLSGTLNPGDRFVGNRYVMSLAQHPPAPTGEGDSPWGGMSGAALFCGDLLAGVIASDPAGRAHAHLEAVPAYVLTHDPGFHAALTDHAPEANATLEPVEWQHLAEPAARTRLMNSPATLLQARRQIVPFRGRTTLLTDLDTWAQEDGFGAKLLHGPGGQGKTRLAQHLADTLTTRGWTALWLRADAPADTLADLSAAAVPLLVIVDYAETRSPQLTALLEAAAQHVGDSAFKVLLLARTAGDWWNDLHAATATAEDLLDGTKTIPLPALEPEPDDSRTQAYHQAVHSYAAHLPHVRGWQHHDWPTLAAPLTTGTPDGLNRPGLDTALTLHMTALADLLDTTTTTAATADAPTVEDRLLVHERRYWTTTATAHHLHPRLTTATLTDALAAAHLLGADTHDQADTLLRHVPALADQTTDRIHAVRRWIAALYPAPTPAQPWGTLQPDRLTEHFTGRHLLHNPTLAHHLAPTATEPQAARLLTLYSRAAAHPALCQLGPHLTTLCTDHAPTLAAPALDVATQTETPQPLIDALNHITDNPTTPPAHLQYLAERLPHTSYNLAPYAAHLTQHLTEHHRTHAHRDPTHLPDFASSLNDLSNRLGDLGRWEEALKAIEEAVEIRRGLARDRPDAFRPELAMSLNNLAVRLGKLGRWEEALKAIEEAVQVYRGLARDRPDAFRPELAMSLNNLAVRLGKLGRQEEALKAIEEAVQVYRGLARDRPDAFRPELAMSLNNLAVRLGKLGRQEEALKAIEEAVQVYRGLARDRPDAFRPELAMSLNNLAVRLGDLGRQEEALKAIEEAVEIRRGLARDRPDAFRPDLASSSNNLAVQLGKLGRQEEALKAIEEAVQVYRGLARDRPDAFRPDLAMSLNNLAVRLGKLGRQEEALKAIEEAVQVYRGLARDRPDAFRPDLAMSSNNLAVRLGKLGRQEEALKAIEEAVEIRRGLARDRPDAFRPDLASSLNNLAVRLAELDRREEALKAIEEAVEIRRKLARDRPKIHQSELEHSLKVLDWLEESTG
>NC_015951.1|WP_014043529.1|94956_95286_+|hypothetical-protein
MEIELADAVAAVRDELLEAAARGAGQDLAFKVGPVELEFAVELRADAKAKTGFKAWVISADAEAGVTRGRTHRVTLTLTPQRPDGSDLLVHGAPSRQQGPGDVSGRIPD
>NC_015951.1|WP_014043528.1|93199_93643_+|hypothetical-protein
MLPDQDGQGWLLERRHVEALLALDSHPSLWALTMEQEDRYEGSAQKQDEREREQASRTLERIGEDEADRRAAAAADLHDGPTPDDPYALELQECPVCDYEAFSSDDGDELGMRVGTGECLVCHYRRSPAIANAIARQMEWERCWERD
>NC_015951.1|WP_043242264.1|92569_92848_-|hypothetical-protein
MSLRFPDPRQRAAIAAAAKNAGVSMQDYILSAAFERATAVEATFLEHFEASVARSHEAFAAEPSGIDPNSEQRAAEQEARRSLENHGQGHAA
>NC_015951.1|WP_014043526.1|92180_92573_-|hypothetical-protein
MSQPDPHQPPRLDVPFLLHAAERLPGDPQVDDLGPLYAAVERMYARVMERDIYGSSHLKAAALLQTLVKLPCLEHSNEAFAWHSAEAFLALNGHPLSYTPKNAVALVRDASAGSLGIARIARQLRDWTTT
>NC_015951.1|WP_014043525.1|90613_92026_+|FAD-dependent-pyridine-nucleotide-disulfide-oxidoreductase
MAPPINSTVPTPRRAVVLGASLTGMLAATVLADHADEVIVVDRDNLPNGPVRRPGLPQARHVHMLWSGGARAIEALVPGLEERWLAAGARRVHMPADLVALTAHGWTRRSPHTQYQIACTRDLLDAVAREHTLDRPGITVRTRTHADGLIGDQHQVRGVRLRHLETGAVTDLEACLVVDATGRGSRAPQWLSQLHLPPVREEIVDPGLVYATRVFRAPAGGENFPVVTFQADPSDGTPGRMATLAPIEGARWLVTLAGTRGAEPTARPEEFEPFARQLRHPLVADLIANAEPLTDVHITRACSNRRRFYEQMRSWPSGFIVLGDAVAAYNPVYGQGMSVAAQGATTLRHMIGKHGLQTTKLARHVQPAIGRLVQGPWNVTTGQDSQYPGAVGKQRPVAARLVHAYVVRLMRTANGRKAVTRALYDVMSLSAPSRRLFHPSVVLQVLLGPGQPPLTEPPLSPTERAYFSRP
>NC_015951.1|WP_078505979.1|107359_107692_-|type-I-E-CRISPR-associated-endoribonuclease-Cas2
MASMITIAASAVPDHLRGALTRWLLEVTPQLYVGTVSARVRDELWSTVTACTADGVAVLVYPADNEQGFELRTAGQQRRRPIDFEGLTLVAFGSLQPDPLSNSQGMANRF
>NC_015951.1|WP_014043535.1|108625_109270_-|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE
MTELWLTRIIPDLRSRQARRDLASAVGMHHRVMQLFPDTAAEQARAALGVLFRIEDGPQGPHLLIQSQAQPDTTALPVGYGTIATKPLTPLLDGLRAGRPVRYRIAASAVRKPGKTTRSLYNLKPIVPLTGAAADDWWIRQARQSGLTIHTVHSTPLDAARGEHAQGKHHIRHARTCFDGTATITDPGLLQRRLMEGIGRGKAYGCGLLTLAPA
>NC_015951.1|WP_014043536.1|109266_110130_-|type-I-E-CRISPR-associated-protein-Cas5/CasD
MTAPSAKPFLGLLLHLAGPLQSWGEHSRFNQRDTAPFPTKSGITGLLACALGRRRGETIEDLASMSLTIRSDRRGVLLRDLHTVGGGLPAKRTVTTAEGKKRPSSAATLLSHRYYLADAAFTAAITSDDHQLLQQCAAALKEPAWPLYLGRRSCPPHGPLLIGDGLFRNPLHHLVRLPLATASSSRHDDAAVEETAAIDFISDQPLDTLPGAPEAAGPHDGATPTGELNDHPLDFGPHQRTYRARAVYRRTLHLPATQRGGLGAAYLTQIHTYLNAYRDDLDQEADA
>NC_015951.1|WP_014043537.1|110126_111302_-|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC
MQRVVHAPGRFVDLHVLQSVPYANLNRDDTNSVKTVQYGNVERTRVSSQCWKRATRLYFERTLGQKALRTRRIGEAVAKDLRERCGWPEDLARRAGQHIAAGSSIKADPPDDDVPAWSTNAMVYVPGTAVTELADLAVQHREVLEAAPDMKKGGKSVLPKGDIDAVLRSRNGVINLLGRMLAEVDGAGVDGAVQVAHAMTTHATDVEVDYFSAVDDITAGWKDTAGSAHMGSTEHSAGVFYRYATVDLDDLLRNLDGDITAARELTSAFAEAFVLSLPQAKKNSTAPHTIPDLVHIGVRSDRPVSFAAAFEEPVTADRHGGYATASRQQLAAYAEAAHQLLGERGLLSSGWASLEDKDLTGLGERHSSFPELIHLSIDTALTPAVPAEAEA
>NC_015951.1|WP_106686061.1|111458_112052_-|type-I-E-CRISPR-associated-protein-Cse2/CasB
MLQLCAQDRGARAALRTGVGKHPDEARRMHRYVAVWLPSLDEDTQRAYYAVAALIAARRDTEAPNQTGRAEKAGKSPGSRFGESLGVAFAAAVARPRDGLRESSAEMRLNLLTRQSVAGIHRHLPAAVRQLCDKKTQPDWAQLVVDLRGWRDQRGRTGRRWLQDFYRARRQAEIAAAKDAAEQADATDADRPAAAAG
>NC_015951.1|WP_014043539.1|112147_113758_-|type-I-E-CRISPR-associated-protein-Cse1/CasA
MERTPPDEGYDLLEQRWIPVRWSAETLADAGGTAADAGEAAAEGGEELPAAVGLRELLERAHEIDALAVTVPPALAGLYRVLYALTARVTGLDRPGDDWSDRRYDVLDDGRLNPDRLWAYLSRYTDRFRLFDPVWPFLQDPRLAQQCEKAAGVNKLITTRPSGNNHAWFQHTRDAAPQAPAAAEAVLHLLVWRYWGPSGRCSSRTVGSVKAANVTAGPLRSALSYHPEGRTLFETLLAGVAEPDPDVRPEADLCPWEWEELPDPVQAPDMVRGPCSGLTARSQHALLLVPEPGGQTVRDAYISWAFLEKMPRDDDFLIWQTSKEGNRYPRLADAGRALWRDVDALLLEDPPGAARPRRPKVFRTAVEACEELRVRAVGFEQDGQAKDIQFVAACTPPLVGLLKQEDVPAAREVGRLRVWGETAGFRLATATRKAWALFTDASKAVECGWSQEAAARFWPRAEEEFWRRVRERDFDGAARGFRRIAEQVYEQVTYGAAGTARGARAREEARVELYGGRPKPAKKTAAAAGGGGGTAR
>NC_015951.1|WP_063644483.1|114015_116835_-|CRISPR-associated-helicase/endonuclease-Cas3
MDETPLPPAGIELDARLWGKEKGLLRPYPLICHLLDTAAIAGRLWDVMLGARSHGLIAERLGLGEDASRRWVCCWAGLHDLGKITPPFQSMSAGRYAVLAADEAYASAPGAEGERGLRHERATHWALTVLFAEWGYPHGPVSQSVAHQVAQLLGGHHGVFGCALEASKLRSPEVWEPGLGGPGWVGQRAVHAGVVRVLTGAGGVPSGRLSGEAAVVVSGVVVVADWLASQESVIAERLPADGWVGDGRELAAHWREAVEAAEWVVAGAGLGSAVFPVRSFAGQFPFSANALQESVERGLPGLVGERGSGLVLVTAPTGDGKTEAALHAASVLGRVSGAGGVFVALPTMATADAMVSRVEGFARVNVGGDRALVLLHSMAWLSRWGGSDQDDRGRVVADGVTALEAGEWLRGGRRGLLAPLGVGTVDQVLTGVLPVRFNVLRLLGLANKVLVVDEAHAYGPWMHMLLVRLLEWLGALSAPVVLLSATLSGRVASSLVEAYRRGCGFREPAVVEPCYPGWLFVDAASGGVSRPRAVGSDRPRTLRVVVEPVAWDVREPAGVPAAGSRRAALVEYLTPVVEQGGCVLVCCTTVDEAQRTFRFLRSVFPELAGEEGGLRLLHARFPAWRREEITGECERAFGKPGAEGVARPVCSVLVATQVVEQSLDLDFDLVVSDLAPLAQLLQRAGRCLRHERGGRPGWVGSDPWLVVLDPLGEEGVEPPRSWGEVYDVSLLVRTRRLLVERAGKGIAVPGDVQQVVDEVYAEDFGERLDQAAAEELRLRDARRVAGEAAETQLAKLTAIPSPYASSLRDLSLLSGAEGLVDEALVTTRLGADSERAVCVYEHAGGALTLDPEGRRELPGVDGRRLFRGQVAEVMRHTVPLPGRWLAGRDERHAALVAWSDRPVLASLVVLRFRLGADERWSCSVGDRSLLLDDLGVSER
>NC_015951.1|WP_014043541.1|117785_118340_-|TetR/AcrR-family-transcriptional-regulator
MRSPRADATRNRDQLLAVATRMFASADAEPSMRAIAREAGVGIATLYRHFPTRESLVDAVYRDQVVRLTTGARELLGQLPPGAAMRRWMDMFGDWIATKNGMLDTLLAMIESGEIAHAQTRTELLAAITTILDAGSAAGDLRSDVTAEDIAASLIGIFTVAPRPEREAKASRLLNLLMDGLRPA
>NC_015951.1|WP_014043542.1|118450_119407_+|NADP-dependent-oxidoreductase
MQEQRDQSPTDSSRAVRLESFGGPEVLDIRDIPAPQASPGQVRVRVTAAGLNPMDWFMTADADTAARFGLSLPAGFGTDYAGVVDQVGDGVTGFAPGDRVFGGALSRAVADFVVIEPAEGTAANEAHHTPGGVDDRTAATLTIAGRTASAALAVVDLGPDDTVLIGGAAGGVGVFAVQLARITGARVIGTGSATSAGFLRDLGAEPVAYGDGLADRVRTLAPSGVTAAIDLHGTETVHAARELGVPDGRICTIAAQVDGVPAANGANAAPGTLEGLARLVAAGQLRVPLAASFPIEQIRRAVELQADRHVKGKVVIDL
>NC_015951.1|WP_014043543.1|119637_120231_-|M15-family-metallopeptidase
MRLVDVRRDSRLLVDERKWQDSAGAFANLRKGVLDRLFKAQTLLPEGMRLLFVEGYRPPSLQRHYFDEYAHQLRTDHPDWSLEQVRSAASRYVSPPEIAPHSAGAAVDLTLADADGRELDMGTRMNATPEESADACYTQADNISGGARSHRDILSTALTTAGLVNYPTEWWHWSYGDRYWALMTGAETAHYGPRELD

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Crispr_ID: NC_015951_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015951_3

116959-117532

TypeI-E

Consensus_repeat	Method
CGGCTCACCTCCGCTCGCGCGGAGAGCAC	PILER-CR
GTGCTCTCCGCGCGAGCGGAGGTGAGCCG	CRISPRCasFinder
GTGCTCTCCGCGCGAGCGGAGGTGAGCCGN	CRT

9 spacers

cas3,cas8e,cse2gr11,cas7,cas5,cas6e,cas2

The CRISPR arrays of NC_015951_3

>merge|NC_015951|3|116959-117532|PILER-CR,CRISPRCasFinder,CRT
GTGCTCTCCGCGCGAGCGGAGGTGAGCCGTCAGCAGGATCGTCACGAGCCCGGTCCATGCCGTGCTCTCCGCGCGAGCGGAGGTGAGCCGGAGATGGCCAAGGGCGGGCAGCCCCAGGCGATGTGCTCTCCGCGCGAGCGGAGGTGAGCCGCACCACATCGACGAGGCGACGGTGGCGGCGAGGTGCTCTCCGCGCGAGCGGAGGTGAGCCGGGTGCCGGTCGCGTGGTTGATCTGGCGGATGGGTGCTCTCCGCGCGAGCGGAGGTGAGCCGCCGCACTGGAAGACCAGCGCCTGGACCGCCTCGTGCTCTCCGCGCGAGCGGAGGTGAGCCGCAAGGGGTGCCGACCGGCGGCGGCGACGTGTGCTCTCCGCGCGAGCGGAGGTGAGCCGAATCGGGACCCCCGCGACCGTGCGACCGGCCCGTGCTCTCCGCGCGAGCGGAGGTGAGCCGTTCATCGCGGCGACCAAGAACGCCGCCGCTCAGTGCTCTCCGGCGAGCGGAGGTGAACCGCCGCGCTCGGTGTACTTGGGGCCCTCGCCGGGGTGCTTTCCGCTCAGGCGGAGGTGACCGG

>NC_015951|3|3|116959-117350|PILER-CR
GTGCTCTCCGCGCGAGCGGAGGTGAGCCG	TCAGCAGGATCGTCACGAGCCCGGTCCATGCC
GTGCTCTCCGCGCGAGCGGAGGTGAGCCG	GAGATGGCCAAGGGCGGGCAGCCCCAGGCGAT
GTGCTCTCCGCGCGAGCGGAGGTGAGCCG	CACCACATCGACGAGGCGACGGTGGCGGCGAG
GTGCTCTCCGCGCGAGCGGAGGTGAGCCG	GGTGCCGGTCGCGTGGTTGATCTGGCGGATGG
GTGCTCTCCGCGCGAGCGGAGGTGAGCCG	CCGCACTGGAAGACCAGCGCCTGGACCGCCTC
GTGCTCTCCGCGCGAGCGGAGGTGAGCCG	CAAGGGGTGCCGACCGGCGGCGGCGACGT
GTGCTCTCCGCGCGAGCGGAGGTGAGCCG

>NC_015951|3|3|116959-117411|CRISPRCasFinder
GTGCTCTCCGCGCGAGCGGAGGTGAGCCG	TCAGCAGGATCGTCACGAGCCCGGTCCATGCC
GTGCTCTCCGCGCGAGCGGAGGTGAGCCG	GAGATGGCCAAGGGCGGGCAGCCCCAGGCGAT
GTGCTCTCCGCGCGAGCGGAGGTGAGCCG	CACCACATCGACGAGGCGACGGTGGCGGCGAG
GTGCTCTCCGCGCGAGCGGAGGTGAGCCG	GGTGCCGGTCGCGTGGTTGATCTGGCGGATGG
GTGCTCTCCGCGCGAGCGGAGGTGAGCCG	CCGCACTGGAAGACCAGCGCCTGGACCGCCTC
GTGCTCTCCGCGCGAGCGGAGGTGAGCCG	CAAGGGGTGCCGACCGGCGGCGGCGACGT
GTGCTCTCCGCGCGAGCGGAGGTGAGCCG	AATCGGGACCCCCGCGACCGTGCGACCGGCCC
GTGCTCTCCGCGCGAGCGGAGGTGAGCCG

>NC_015951|3|3|116959-117532|CRT
GTGCTCTCCGCGCGAGCGGAGGTGAGCCG	TCAGCAGGATCGTCACGAGCCCGGTCCATGCC
GTGCTCTCCGCGCGAGCGGAGGTGAGCCG	GAGATGGCCAAGGGCGGGCAGCCCCAGGCGAT
GTGCTCTCCGCGCGAGCGGAGGTGAGCCG	CACCACATCGACGAGGCGACGGTGGCGGCGAG
GTGCTCTCCGCGCGAGCGGAGGTGAGCCG	GGTGCCGGTCGCGTGGTTGATCTGGCGGATGG
GTGCTCTCCGCGCGAGCGGAGGTGAGCCG	CCGCACTGGAAGACCAGCGCCTGGACCGCCTC
GTGCTCTCCGCGCGAGCGGAGGTGAGCCG	CAAGGGGTGCCGACCGGCGGCGGCGACGT
GTGCTCTCCGCGCGAGCGGAGGTGAGCCG	AATCGGGACCCCCGCGACCGTGCGACCGGCCC
GTGCTCTCCGCGCGAGCGGAGGTGAGCCG	TTCATCGCGGCGACCAAGAACGCCGCCGCTCA
GTGCTCTCCGGCGAGCGGAGGTGAACCGC	CGCGCTCGGTGTACTTGGGGCCCTCGCCGGG
GTGCTTTCCGCTCAGGCGGAGGTGACCGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_015951.1\|WP_063644483.1\|114015_116835_-\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|182031
NC_015951.1\|WP_014043537.1\|110126_111302_-\|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	cas7	pfam09344_cas7_CAS-I-E	gnl\|CDD\|378153
NC_015951.1\|WP_014043541.1\|117785_118340_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NC_015951.1\|WP_014043544.1\|120869_121121_-\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl\|CDD\|224937
NC_015951.1\|WP_014043542.1\|118450_119407_+\|NADP-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|176191
NC_015951.1\|WP_167543316.1\|121936_122107_-\|hypothetical-protein	unknown	unknown	unknown
NC_015951.1\|WP_014043545.1\|121117_121375_-\|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin	unknown	unknown	gnl\|CDD\|376852
NC_015951.1\|WP_014043536.1\|109266_110130_-\|type-I-E-CRISPR-associated-protein-Cas5/CasD	cas5	cd09756_cas5_CAS-I-E	gnl\|CDD\|273842
NC_015951.1\|WP_167543317.1\|123876_124050_+\|site-specific-DNA-methyltransferase	unknown	unknown	gnl\|CDD\|334588
NC_015951.1\|WP_106686061.1\|111458_112052_-\|type-I-E-CRISPR-associated-protein-Cse2/CasB	cse2gr11	pfam09485_cse2gr11_CAS-I-E	gnl\|CDD\|378191
NC_015951.1\|WP_014043539.1\|112147_113758_-\|type-I-E-CRISPR-associated-protein-Cse1/CasA	cas8e	cd09729_cas8e_CAS-I-E	gnl\|CDD\|187860
NC_015951.1\|WP_150112974.1\|120378_120573_-\|hypothetical-protein	unknown	unknown	unknown
NC_015951.1\|WP_014043532.1\|100514_101747_+\|hypothetical-protein	unknown	unknown	unknown
NC_015951.1\|WP_014043534.1\|104999_106613_-\|ISL3-family-transposase	unknown	unknown	gnl\|CDD\|225995
NC_015951.1\|WP_043242275.1\|122223_123567_+\|recombinase	unknown	unknown	gnl\|CDD\|367266
NC_015951.1\|WP_014043535.1\|108625_109270_-\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	cas6e	cd09727_cas6e_CAS-I-E	gnl\|CDD\|187858
NC_015951.1\|WP_014043547.1\|124157_125429_+\|IS256-family-transposase	unknown	unknown	gnl\|CDD\|307151
NC_015951.1\|WP_078505979.1\|107359_107692_-\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	cas2	pfam09707_cas2_CAS-I-E	gnl\|CDD\|378244
NC_015951.1\|WP_014043543.1\|119637_120231_-\|M15-family-metallopeptidase	unknown	unknown	gnl\|CDD\|350618
NC_015951.1\|WP_014043533.1\|104100_104304_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_015951.1\|WP_063644483.1\|114015_116835_-\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|182031	PRK09694, PRK09694, CRISPR-associated helicase/endonuclease Cas3.	1.99047e-78
NC_015951.1\|WP_014043537.1\|110126_111302_-\|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	gnl\|CDD\|378153	pfam09344, Cas_CT1975, CT1975-like protein. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is represented by CT1975 of Chlorobium tepidum.	5.52102e-145
NC_015951.1\|WP_014043541.1\|117785_118340_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	3.99052e-09
NC_015951.1\|WP_014043544.1\|120869_121121_-\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl\|CDD\|224937	COG2026, RelE, Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning].	2.13551e-08
NC_015951.1\|WP_014043542.1\|118450_119407_+\|NADP-dependent-oxidoreductase	gnl\|CDD\|176191	cd05289, MDR_like_2, alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases. Members identified as zinc-dependent alcohol dehydrogenases and quinone oxidoreductase. QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR actin the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	8.72636e-82
NC_015951.1\|WP_043242275.1\|122223_123567_+\|recombinase	gnl\|CDD\|367266	pfam02945, Endonuclease_7, Recombination endonuclease VII.	1.46082e-06
NC_015951.1\|WP_014043545.1\|121117_121375_-\|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin	gnl\|CDD\|376852	pfam02604, PhdYeFM_antitox, Antitoxin Phd_YefM, type II toxin-antitoxin system. Members of this family act as antitoxins in type II toxin-antitoxin systems. When bound to their toxin partners, they can bind DNA via the N-terminus and repress the expression of operons containing genes encoding the toxin and the antitoxin. This domain complexes with Txe toxins containing pfam06769, Fic/DOC toxins containing pfam02661 and YafO toxins containing pfam13957.	2.78666e-10
NC_015951.1\|WP_014043536.1\|109266_110130_-\|type-I-E-CRISPR-associated-protein-Cas5/CasD	gnl\|CDD\|273842	TIGR01868, hypothetical_protein, CRISPR-associated protein Cas5/CasD, subtype I-E/ECOLI. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is part of the ECOLI subtype CRISPR/Cas locus, and now characterized as part of the CASCADE complex of that system. It shares a small N-terminal homology region with members of several other CRISPR/Cas subtypes, and we view the families that share this region as being Cas5.	4.41967e-52
NC_015951.1\|WP_167543317.1\|123876_124050_+\|site-specific-DNA-methyltransferase	gnl\|CDD\|334588	pfam01555, N6_N4_Mtase, DNA methylase. Members of this family are DNA methylases. The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases.	7.77573e-08
NC_015951.1\|WP_106686061.1\|111458_112052_-\|type-I-E-CRISPR-associated-protein-Cse2/CasB	gnl\|CDD\|378191	pfam09485, CRISPR_Cse2, CRISPR-associated protein Cse2 (CRISPR_cse2). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family of proteins, represented by CT1973 from Chlorobaculum tepidum, is encoded by genes found in the CRISPR/Cas subtype Ecoli regions of many bacteria (most of which are mesophiles), and not in Archaea. It is designated Cse2.	5.89606e-20
NC_015951.1\|WP_014043539.1\|112147_113758_-\|type-I-E-CRISPR-associated-protein-Cse1/CasA	gnl\|CDD\|187860	cd09729, Cse1_I-E, CRISPR/Cas system-associated protein Cse1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Large proteins, some contain Zn-finger domain; subunit of the Cascade complex; signature gene for I-E subtype; also known as Cse1/CasA/YgcL family.	1.89168e-78
NC_015951.1\|WP_014043543.1\|119637_120231_-\|M15-family-metallopeptidase	gnl\|CDD\|350618	cd14843, D-Ala-D-Ala_dipeptidase_like, D-Ala-D-Ala dipeptidase, includes uncharacterized enzymes. This subfamily of D-Ala-D-Ala dipeptidase (also known as D-alanyl-D-alanine dipeptidase vanX; VanX; EC 3.4.13.22) also includes several uncharacterized proteins. This is a Zn2+-dependent enzyme that mediates resistance to the antibiotic vancomycin in Enterococci and other bacteria (both Gram-positive and Gram-negative). It is part of a gene cluster that affects cell-wall biosynthesis. The operon triggers the termination of peptidoglycan precursors by D-Ala-(R)-lactate instead of D-Ala-D-Ala dipeptides. The enzyme is stereospecific, as L-Ala-L-Ala, D-Ala-L-Ala and L-Ala-D-Ala are not substrates. It belongs in the MEROPS peptidase family M15, subfamily D.	1.24024e-62
NC_015951.1\|WP_014043534.1\|104999_106613_-\|ISL3-family-transposase	gnl\|CDD\|225995	COG3464, COG3464, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	4.95984e-31
NC_015951.1\|WP_014043535.1\|108625_109270_-\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	gnl\|CDD\|187858	cd09727, Cas6_I-E, CRISPR/Cas system-associated RAMP superfamily protein Cas6e. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas6e is an endoribonuclease that generates crRNA; This family is specific for CRISPR/Cas system I-E subtype; Homologous to Cas6 (RAMP superfamily protein); Possesses double RRM/ferredoxin fold; also known as Cse3 family.	2.39855e-61
NC_015951.1\|WP_078505979.1\|107359_107692_-\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	gnl\|CDD\|378244	pfam09707, Cas_Cas2CT1978, CRISPR-associated protein (Cas_Cas2CT1978). This entry represents a minor branch of the Cas2 family of CRISPR-associated protein which are found in IPR003799. Cas proteins are found adjacent to a characteristic short, palindromic repeat cluster termed CRISPR, a probable mobile DNA element.	6.07646e-40
NC_015951.1\|WP_014043547.1\|124157_125429_+\|IS256-family-transposase	gnl\|CDD\|307151	pfam00872, Transposase_mut, Transposase, Mutator family.	8.28357e-125

>NC_015951.1|WP_063644483.1|114015_116835_-|CRISPR-associated-helicase/endonuclease-Cas3
MDETPLPPAGIELDARLWGKEKGLLRPYPLICHLLDTAAIAGRLWDVMLGARSHGLIAERLGLGEDASRRWVCCWAGLHDLGKITPPFQSMSAGRYAVLAADEAYASAPGAEGERGLRHERATHWALTVLFAEWGYPHGPVSQSVAHQVAQLLGGHHGVFGCALEASKLRSPEVWEPGLGGPGWVGQRAVHAGVVRVLTGAGGVPSGRLSGEAAVVVSGVVVVADWLASQESVIAERLPADGWVGDGRELAAHWREAVEAAEWVVAGAGLGSAVFPVRSFAGQFPFSANALQESVERGLPGLVGERGSGLVLVTAPTGDGKTEAALHAASVLGRVSGAGGVFVALPTMATADAMVSRVEGFARVNVGGDRALVLLHSMAWLSRWGGSDQDDRGRVVADGVTALEAGEWLRGGRRGLLAPLGVGTVDQVLTGVLPVRFNVLRLLGLANKVLVVDEAHAYGPWMHMLLVRLLEWLGALSAPVVLLSATLSGRVASSLVEAYRRGCGFREPAVVEPCYPGWLFVDAASGGVSRPRAVGSDRPRTLRVVVEPVAWDVREPAGVPAAGSRRAALVEYLTPVVEQGGCVLVCCTTVDEAQRTFRFLRSVFPELAGEEGGLRLLHARFPAWRREEITGECERAFGKPGAEGVARPVCSVLVATQVVEQSLDLDFDLVVSDLAPLAQLLQRAGRCLRHERGGRPGWVGSDPWLVVLDPLGEEGVEPPRSWGEVYDVSLLVRTRRLLVERAGKGIAVPGDVQQVVDEVYAEDFGERLDQAAAEELRLRDARRVAGEAAETQLAKLTAIPSPYASSLRDLSLLSGAEGLVDEALVTTRLGADSERAVCVYEHAGGALTLDPEGRRELPGVDGRRLFRGQVAEVMRHTVPLPGRWLAGRDERHAALVAWSDRPVLASLVVLRFRLGADERWSCSVGDRSLLLDDLGVSER
>NC_015951.1|WP_014043539.1|112147_113758_-|type-I-E-CRISPR-associated-protein-Cse1/CasA
MERTPPDEGYDLLEQRWIPVRWSAETLADAGGTAADAGEAAAEGGEELPAAVGLRELLERAHEIDALAVTVPPALAGLYRVLYALTARVTGLDRPGDDWSDRRYDVLDDGRLNPDRLWAYLSRYTDRFRLFDPVWPFLQDPRLAQQCEKAAGVNKLITTRPSGNNHAWFQHTRDAAPQAPAAAEAVLHLLVWRYWGPSGRCSSRTVGSVKAANVTAGPLRSALSYHPEGRTLFETLLAGVAEPDPDVRPEADLCPWEWEELPDPVQAPDMVRGPCSGLTARSQHALLLVPEPGGQTVRDAYISWAFLEKMPRDDDFLIWQTSKEGNRYPRLADAGRALWRDVDALLLEDPPGAARPRRPKVFRTAVEACEELRVRAVGFEQDGQAKDIQFVAACTPPLVGLLKQEDVPAAREVGRLRVWGETAGFRLATATRKAWALFTDASKAVECGWSQEAAARFWPRAEEEFWRRVRERDFDGAARGFRRIAEQVYEQVTYGAAGTARGARAREEARVELYGGRPKPAKKTAAAAGGGGGTAR
>NC_015951.1|WP_106686061.1|111458_112052_-|type-I-E-CRISPR-associated-protein-Cse2/CasB
MLQLCAQDRGARAALRTGVGKHPDEARRMHRYVAVWLPSLDEDTQRAYYAVAALIAARRDTEAPNQTGRAEKAGKSPGSRFGESLGVAFAAAVARPRDGLRESSAEMRLNLLTRQSVAGIHRHLPAAVRQLCDKKTQPDWAQLVVDLRGWRDQRGRTGRRWLQDFYRARRQAEIAAAKDAAEQADATDADRPAAAAG
>NC_015951.1|WP_014043537.1|110126_111302_-|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC
MQRVVHAPGRFVDLHVLQSVPYANLNRDDTNSVKTVQYGNVERTRVSSQCWKRATRLYFERTLGQKALRTRRIGEAVAKDLRERCGWPEDLARRAGQHIAAGSSIKADPPDDDVPAWSTNAMVYVPGTAVTELADLAVQHREVLEAAPDMKKGGKSVLPKGDIDAVLRSRNGVINLLGRMLAEVDGAGVDGAVQVAHAMTTHATDVEVDYFSAVDDITAGWKDTAGSAHMGSTEHSAGVFYRYATVDLDDLLRNLDGDITAARELTSAFAEAFVLSLPQAKKNSTAPHTIPDLVHIGVRSDRPVSFAAAFEEPVTADRHGGYATASRQQLAAYAEAAHQLLGERGLLSSGWASLEDKDLTGLGERHSSFPELIHLSIDTALTPAVPAEAEA
>NC_015951.1|WP_014043536.1|109266_110130_-|type-I-E-CRISPR-associated-protein-Cas5/CasD
MTAPSAKPFLGLLLHLAGPLQSWGEHSRFNQRDTAPFPTKSGITGLLACALGRRRGETIEDLASMSLTIRSDRRGVLLRDLHTVGGGLPAKRTVTTAEGKKRPSSAATLLSHRYYLADAAFTAAITSDDHQLLQQCAAALKEPAWPLYLGRRSCPPHGPLLIGDGLFRNPLHHLVRLPLATASSSRHDDAAVEETAAIDFISDQPLDTLPGAPEAAGPHDGATPTGELNDHPLDFGPHQRTYRARAVYRRTLHLPATQRGGLGAAYLTQIHTYLNAYRDDLDQEADA
>NC_015951.1|WP_014043535.1|108625_109270_-|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE
MTELWLTRIIPDLRSRQARRDLASAVGMHHRVMQLFPDTAAEQARAALGVLFRIEDGPQGPHLLIQSQAQPDTTALPVGYGTIATKPLTPLLDGLRAGRPVRYRIAASAVRKPGKTTRSLYNLKPIVPLTGAAADDWWIRQARQSGLTIHTVHSTPLDAARGEHAQGKHHIRHARTCFDGTATITDPGLLQRRLMEGIGRGKAYGCGLLTLAPA
>NC_015951.1|WP_078505979.1|107359_107692_-|type-I-E-CRISPR-associated-endoribonuclease-Cas2
MASMITIAASAVPDHLRGALTRWLLEVTPQLYVGTVSARVRDELWSTVTACTADGVAVLVYPADNEQGFELRTAGQQRRRPIDFEGLTLVAFGSLQPDPLSNSQGMANRF
>NC_015951.1|WP_014043534.1|104999_106613_-|ISL3-family-transposase
MSDVEIGDVLFADLDGLQVDKVELSEDAVSVTARACAGEATCPACGTRSRRVHSCYQRRLADAAVGGRPVVVHLLVRRFRCPVASCPRTTFVEQIDGLTFRHGRRSQRLHTVLQMVALMLAGRGGARLAAVLSAAVSRSTLLRLIHALPDPSSVTPRVLGVDDFALRKGHIYGTVLIDVETRRPIDLLPDRESATLARWLSEHPGVEIICRDRASGYAEGARLGAPDAVQVADRWHLFHNLTEAVDRCVTRHSTRLRTPEPPPSPAMSTAPAAELEKISGAAKAERAAHRCADRTRDRHQEIHALIDKGLTLREISRELGLARNTVRKFARAATAEELSAGKWQGRASILDDYKPYLHQRWQEGCTSAKKLFEEIKAAGFRGGYSVVRDYLQPLRAGAKPADRAHRPPSVRDVTGWITRHPDSLTQDETLHLKDILARCPELDATAEHVRTFAEMMNARTGHKLAAWVDSVKAGKLPELVSFVNGIGCDLRAVEAGLTLPFSSGAVEGQVNRIKMLKRQMFGRAGLALLRKRVLLAA
>NC_015951.1|WP_014043533.1|104100_104304_-|hypothetical-protein
MLAVNAAYHKPTVVVMARITPPADSNEPLALDHLGLAAEMVYDTDTIDVHIAKDRFGPAPRLTTVVW
>NC_015951.1|WP_014043532.1|100514_101747_+|hypothetical-protein
MEAANLASIAMQMISGLATSAGTSVGTAAGEEVSRLVRDRLRGSQEGRAALTQLDQEPGSPEAESQVRTILTRALADDPDFATRLETAATQNTLHAGRDMTVQTVSVSSSTVKGTINIGPLTITKSRGAYLALGAAVIALALLLALGTYGAVQVISINNSPSTPSPDPTTTPATPSTGSTTTPQAGSGPKLEPITTRNAAKAVMPDQSVLPAGWSAAGEPDVVTASEAKYPVDPDDPPLEGGIELTGPDYGITLQMDFFETAASASNRFNRYDIIAGWEIDQHSESLAMPKIGDDSMAFIDYTPSDHVAGMVAAARIGTITCQVAATDTVHPADHADEVFAFTRMCIQRAKQGQQRRTPEASWKPAPSHGHRLPCLGAGAGKGSRLVAGVVADPHRQCLEGADSLALMRR
>NC_015951.1|WP_014043541.1|117785_118340_-|TetR/AcrR-family-transcriptional-regulator
MRSPRADATRNRDQLLAVATRMFASADAEPSMRAIAREAGVGIATLYRHFPTRESLVDAVYRDQVVRLTTGARELLGQLPPGAAMRRWMDMFGDWIATKNGMLDTLLAMIESGEIAHAQTRTELLAAITTILDAGSAAGDLRSDVTAEDIAASLIGIFTVAPRPEREAKASRLLNLLMDGLRPA
>NC_015951.1|WP_014043542.1|118450_119407_+|NADP-dependent-oxidoreductase
MQEQRDQSPTDSSRAVRLESFGGPEVLDIRDIPAPQASPGQVRVRVTAAGLNPMDWFMTADADTAARFGLSLPAGFGTDYAGVVDQVGDGVTGFAPGDRVFGGALSRAVADFVVIEPAEGTAANEAHHTPGGVDDRTAATLTIAGRTASAALAVVDLGPDDTVLIGGAAGGVGVFAVQLARITGARVIGTGSATSAGFLRDLGAEPVAYGDGLADRVRTLAPSGVTAAIDLHGTETVHAARELGVPDGRICTIAAQVDGVPAANGANAAPGTLEGLARLVAAGQLRVPLAASFPIEQIRRAVELQADRHVKGKVVIDL
>NC_015951.1|WP_014043543.1|119637_120231_-|M15-family-metallopeptidase
MRLVDVRRDSRLLVDERKWQDSAGAFANLRKGVLDRLFKAQTLLPEGMRLLFVEGYRPPSLQRHYFDEYAHQLRTDHPDWSLEQVRSAASRYVSPPEIAPHSAGAAVDLTLADADGRELDMGTRMNATPEESADACYTQADNISGGARSHRDILSTALTTAGLVNYPTEWWHWSYGDRYWALMTGAETAHYGPRELD
>NC_015951.1|WP_150112974.1|120378_120573_-|hypothetical-protein
METFGWASATIAGLTCITWIASHVLDQIPVICHKAAKAIRSIRALRNEIRSEAREREGTTPNER
>NC_015951.1|WP_014043544.1|120869_121121_-|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MTYAIIWDEGAVNAAARFLKDDPDGLRQLMDAVDLLADTPRPAGTAEYGSPDLRRMHVGRYRVLYEITETTVTIVVIHIGRTG
>NC_015951.1|WP_014043545.1|121117_121375_-|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin
MSDTLPITEARARFGSLVRRASHARERITITDHGQPAAVLINPQELADLEDALALAQYRARQASGEATGVPHEQVRAQLGLGHAS
>NC_015951.1|WP_167543316.1|121936_122107_-|hypothetical-protein
MTSNLSGVDLVRQALAAACEQAKKNRGHRKEKTKRRTGQAVRRDGREPLGCVPSSP
>NC_015951.1|WP_043242275.1|122223_123567_+|recombinase
MSERVMPGRTDGLITLGAADALWVDLTADSAVPTASGAFTCSPAHARVGYVLLGGHVVATVKASGGQRSVPELEVRRAAAELNAVGMDRQDLIRIGPFRRAPRQERNEETPLRWRQRITEELEELGGPERAARGEVGRPYHLAGIDWRRTLVEQTRDGTQRTWWLPRAVVRLLDAAEHTETQWVQAARTRQASAAVTEPPSHPRQAQDADGRQTTSPEGPTASLRPYNAELEGQQYSVLSRKPGTSRRVAGWECAVCRTAPAAVLDHCHEHGYVRAPVCQSCNTQEHPDHLYSNDIRVANRYTRLFHTDTDDWLRHWHRCPGCRARTTLPLPHLAAWTAHIACRSLRPTHPAPRGRKPCGVLRVSWTSSQNAPRSCLLTVAVDFCPSGEHRVLARVSYREAAERFRHWLAETAPAVAAAAGPDRLDGLPAQSRPVIADTSGEGLALF
>NC_015951.1|WP_167543317.1|123876_124050_+|site-specific-DNA-methyltransferase
MPTTPLKPPTELEDARHFAAMPETLTQHLPILGYAPPLGIVLDPFGGTGTTTAMDVA
>NC_015951.1|WP_014043547.1|124157_125429_+|IS256-family-transposase
MNDNEILAVGPVEDELVDEVVERLMDRADASGAALLGEGGLLTEVTRAVLERALDAEMTDHLGYEKHDPAGHGSGNSRNGTSRKTVLTDAGAVTLAVPRDRDGSFEPQLVPKHARRLAGFNEQVLSLYARGMSVRDIRSHLAGMYGVEVSPDLISKVTDAVTDELDAWRNRPLDAVWPIIYIDALWVKIRSGSVASRPVYLAVGVDMDGCKDVLGLWAGDEGEGATTWMTVLSELRNRGVEDVCIVACDGLKGLPVAVTATWPKATVQTCVIHLIRASLRFASKQHHAKLVTELKAIYTAPTEQAAEQALADFTAGELGQRYPAIVRTWQAAWSEFTPYLAFPPEIRKVVYSTNLIESINARLRKATRNRGHFPSEQAALKVLYLAIREQVTPRARDVNHVAAHWKKALNQFSLFFEDRLNTK

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Crispr_ID: NC_015951_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015951_4

125606-126116

TypeI-E

Consensus_repeat	Method
CTCCGCGCGAGCGGAGGTGACCCG	CRISPRCasFinder

8 spacers

The CRISPR arrays of NC_015951_4

>merge|NC_015951|4|125606-126116|CRISPRCasFinder
CTCCGCGCGAGCGGAGGTGAGCCGCATCTGACCGGAGGCGCCCAGTGACCGCAGGCGTCCTCTCCGCGCGAGCGGAGGTGAGCCGTTGCCCCACACGTTGCCGTCGGCGTATCTGACGTCCTCTCCGCGCGAGCGGAGGTGAGCCATGCTGGCCGATCATGTGACGCCAGATCGCGCGGGGCCCTCTCCACGAGCGGTGGTGAACCGGTCTGACGTCCCTTGGAGGGGTGGCAGGCCCAGTGCTTTCCACACGAGCGGAGGTGAGCCGAAGCACGACGCGGTGACGCGTGAGCAGCTGCTGTGCTCTGCGCGCGAGTGGAGGTGAGCCATTCCGTGGGGTCAAGGACGACCAGGGCCTGCCGTGCTCCGCGCGAGCGGAGGTGACCCGGTGCCATCCATCACTGCGTAGGCGTCGCACCGGTGCTCTCCGCGCGAGCGGAGGTGACCCGCTGACCGTCGACACGGGTATCGCCCACAGTCAGGCCTTCTTCGCCCGAGCGGAGGTGAGAGC

>NC_015951|4|4|125606-126116|CRISPRCasFinder
CTCCGCGCGAGCGGAGGTGAGCCG	CATCTGACCGGAGGCGCCCAGTGACCGCAGGCGTCCT
CTCCGCGCGAGCGGAGGTGAGCCG	TTGCCCCACACGTTGCCGTCGGCGTATCTGACGTCCT
CTCCGCGCGAGCGGAGGTGAGCCA	TGCTGGCCGATCATGTGACGCCAGATCGCGCGGGGCC
CTCTCCACGAGCGGTGGTGAACCG	GTCTGACGTCCCTTGGAGGGGTGGCAGGCCCAGTGCT
TTCCACACGAGCGGAGGTGAGCCG	AAGCACGACGCGGTGACGCGTGAGCAGCTGCTGTGCT
CTGCGCGCGAGTGGAGGTGAGCCA	TTCCGTGGGGTCAAGGACGACCAGGGCCTGCCGTG
CTCCGCGCGAGCGGAGGTGACCCG	GTGCCATCCATCACTGCGTAGGCGTCGCACCGGTGCT
CTCCGCGCGAGCGGAGGTGACCCG	CTGACCGTCGACACGGGTATCGCCCACAGTCAGGCCTT
CTTCGCCCGAGCGGAGGTGAGAGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015951.1\|WP_150112974.1\|120378_120573_-\|hypothetical-protein	unknown	unknown	unknown
NC_015951.1\|WP_014043542.1\|118450_119407_+\|NADP-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|176191
NC_015951.1\|WP_014043545.1\|121117_121375_-\|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin	unknown	unknown	gnl\|CDD\|376852
NC_015951.1\|WP_043242275.1\|122223_123567_+\|recombinase	unknown	unknown	gnl\|CDD\|367266
NC_015951.1\|WP_014043554.1\|133487_133790_+\|hypothetical-protein	unknown	unknown	unknown
NC_015951.1\|WP_167543317.1\|123876_124050_+\|site-specific-DNA-methyltransferase	unknown	unknown	gnl\|CDD\|334588
NC_015951.1\|WP_014043544.1\|120869_121121_-\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl\|CDD\|224937
NC_015951.1\|WP_014043541.1\|117785_118340_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NC_015951.1\|WP_043242280.1\|126302_127844_+\|IS21-family-transposase	unknown	unknown	gnl\|CDD\|366234
NC_015951.1\|WP_014043543.1\|119637_120231_-\|M15-family-metallopeptidase	unknown	unknown	gnl\|CDD\|350618
NC_015951.1\|WP_014043557.1\|135473_136298_-\|hypothetical-protein	unknown	unknown	unknown
NC_015951.1\|WP_014043550.1\|128769_129174_-\|hypothetical-protein	unknown	unknown	unknown
NC_015951.1\|WP_167543316.1\|121936_122107_-\|hypothetical-protein	unknown	unknown	unknown
NC_015951.1\|WP_050994194.1\|128032_128758_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|366760
NC_015951.1\|WP_014043555.1\|133782_134055_+\|hypothetical-protein	unknown	unknown	unknown
NC_015951.1\|WP_014043552.1\|131420_131834_-\|hypothetical-protein	unknown	unknown	unknown
NC_015951.1\|WP_043242286.1\|134993_135254_-\|hypothetical-protein	unknown	unknown	unknown
NC_015951.1\|WP_014043547.1\|124157_125429_+\|IS256-family-transposase	unknown	unknown	gnl\|CDD\|307151
NC_015951.1\|WP_167543318.1\|131930_133388_-\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271175
NC_015951.1\|WP_106686045.1\|129860_130826_-\|adenosine-deaminase	unknown	unknown	gnl\|CDD\|236480

Protein	Function_ID	Function_description	E-value
NC_015951.1\|WP_014043541.1\|117785_118340_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	3.99052e-09
NC_015951.1\|WP_014043542.1\|118450_119407_+\|NADP-dependent-oxidoreductase	gnl\|CDD\|176191	cd05289, MDR_like_2, alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases. Members identified as zinc-dependent alcohol dehydrogenases and quinone oxidoreductase. QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR actin the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	8.72636e-82
NC_015951.1\|WP_014043545.1\|121117_121375_-\|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin	gnl\|CDD\|376852	pfam02604, PhdYeFM_antitox, Antitoxin Phd_YefM, type II toxin-antitoxin system. Members of this family act as antitoxins in type II toxin-antitoxin systems. When bound to their toxin partners, they can bind DNA via the N-terminus and repress the expression of operons containing genes encoding the toxin and the antitoxin. This domain complexes with Txe toxins containing pfam06769, Fic/DOC toxins containing pfam02661 and YafO toxins containing pfam13957.	2.78666e-10
NC_015951.1\|WP_043242275.1\|122223_123567_+\|recombinase	gnl\|CDD\|367266	pfam02945, Endonuclease_7, Recombination endonuclease VII.	1.46082e-06
NC_015951.1\|WP_167543317.1\|123876_124050_+\|site-specific-DNA-methyltransferase	gnl\|CDD\|334588	pfam01555, N6_N4_Mtase, DNA methylase. Members of this family are DNA methylases. The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases.	7.77573e-08
NC_015951.1\|WP_014043544.1\|120869_121121_-\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl\|CDD\|224937	COG2026, RelE, Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning].	2.13551e-08
NC_015951.1\|WP_043242280.1\|126302_127844_+\|IS21-family-transposase	gnl\|CDD\|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	2.18588e-13
NC_015951.1\|WP_014043543.1\|119637_120231_-\|M15-family-metallopeptidase	gnl\|CDD\|350618	cd14843, D-Ala-D-Ala_dipeptidase_like, D-Ala-D-Ala dipeptidase, includes uncharacterized enzymes. This subfamily of D-Ala-D-Ala dipeptidase (also known as D-alanyl-D-alanine dipeptidase vanX; VanX; EC 3.4.13.22) also includes several uncharacterized proteins. This is a Zn2+-dependent enzyme that mediates resistance to the antibiotic vancomycin in Enterococci and other bacteria (both Gram-positive and Gram-negative). It is part of a gene cluster that affects cell-wall biosynthesis. The operon triggers the termination of peptidoglycan precursors by D-Ala-(R)-lactate instead of D-Ala-D-Ala dipeptides. The enzyme is stereospecific, as L-Ala-L-Ala, D-Ala-L-Ala and L-Ala-D-Ala are not substrates. It belongs in the MEROPS peptidase family M15, subfamily D.	1.24024e-62
NC_015951.1\|WP_050994194.1\|128032_128758_+\|ATP-binding-protein	gnl\|CDD\|366760	pfam01695, IstB_IS21, IstB-like ATP binding protein. This protein contains an ATP/GTP binding P-loop motif. It is found associated with IS21 family insertion sequences. The function of this protein is unknown, but it may perform a transposase function.	2.37415e-57
NC_015951.1\|WP_014043547.1\|124157_125429_+\|IS256-family-transposase	gnl\|CDD\|307151	pfam00872, Transposase_mut, Transposase, Mutator family.	8.28357e-125
NC_015951.1\|WP_167543318.1\|131930_133388_-\|site-specific-integrase	gnl\|CDD\|271175	cd00397, DNA_BRE_C, DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine based site-specific recombinases (integrases) that share the same fold in their catalytic domain containing conserved active site residues. The best-studied members of this diverse superfamily include Human topoisomerase I, the bacteriophage lambda integrase, the bacteriophage P1 Cre recombinase, the yeast Flp recombinase, and the bacterial XerD/C recombinases. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. The enzymes differ in that topoisomerases cleave and then rejoin the same 5' and 3' termini, whereas a site-specific recombinase transfers a 5' hydroxyl generated by recombinase cleavage to a new 3' phosphate partner located in a different duplex region. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.	1.06304e-08
NC_015951.1\|WP_106686045.1\|129860_130826_-\|adenosine-deaminase	gnl\|CDD\|236480	PRK09358, PRK09358, adenosine deaminase; Provisional.	2.08936e-124

>NC_015951.1|WP_014043547.1|124157_125429_+|IS256-family-transposase
MNDNEILAVGPVEDELVDEVVERLMDRADASGAALLGEGGLLTEVTRAVLERALDAEMTDHLGYEKHDPAGHGSGNSRNGTSRKTVLTDAGAVTLAVPRDRDGSFEPQLVPKHARRLAGFNEQVLSLYARGMSVRDIRSHLAGMYGVEVSPDLISKVTDAVTDELDAWRNRPLDAVWPIIYIDALWVKIRSGSVASRPVYLAVGVDMDGCKDVLGLWAGDEGEGATTWMTVLSELRNRGVEDVCIVACDGLKGLPVAVTATWPKATVQTCVIHLIRASLRFASKQHHAKLVTELKAIYTAPTEQAAEQALADFTAGELGQRYPAIVRTWQAAWSEFTPYLAFPPEIRKVVYSTNLIESINARLRKATRNRGHFPSEQAALKVLYLAIREQVTPRARDVNHVAAHWKKALNQFSLFFEDRLNTK
>NC_015951.1|WP_167543317.1|123876_124050_+|site-specific-DNA-methyltransferase
MPTTPLKPPTELEDARHFAAMPETLTQHLPILGYAPPLGIVLDPFGGTGTTTAMDVA
>NC_015951.1|WP_043242275.1|122223_123567_+|recombinase
MSERVMPGRTDGLITLGAADALWVDLTADSAVPTASGAFTCSPAHARVGYVLLGGHVVATVKASGGQRSVPELEVRRAAAELNAVGMDRQDLIRIGPFRRAPRQERNEETPLRWRQRITEELEELGGPERAARGEVGRPYHLAGIDWRRTLVEQTRDGTQRTWWLPRAVVRLLDAAEHTETQWVQAARTRQASAAVTEPPSHPRQAQDADGRQTTSPEGPTASLRPYNAELEGQQYSVLSRKPGTSRRVAGWECAVCRTAPAAVLDHCHEHGYVRAPVCQSCNTQEHPDHLYSNDIRVANRYTRLFHTDTDDWLRHWHRCPGCRARTTLPLPHLAAWTAHIACRSLRPTHPAPRGRKPCGVLRVSWTSSQNAPRSCLLTVAVDFCPSGEHRVLARVSYREAAERFRHWLAETAPAVAAAAGPDRLDGLPAQSRPVIADTSGEGLALF
>NC_015951.1|WP_167543316.1|121936_122107_-|hypothetical-protein
MTSNLSGVDLVRQALAAACEQAKKNRGHRKEKTKRRTGQAVRRDGREPLGCVPSSP
>NC_015951.1|WP_014043545.1|121117_121375_-|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin
MSDTLPITEARARFGSLVRRASHARERITITDHGQPAAVLINPQELADLEDALALAQYRARQASGEATGVPHEQVRAQLGLGHAS
>NC_015951.1|WP_014043544.1|120869_121121_-|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MTYAIIWDEGAVNAAARFLKDDPDGLRQLMDAVDLLADTPRPAGTAEYGSPDLRRMHVGRYRVLYEITETTVTIVVIHIGRTG
>NC_015951.1|WP_150112974.1|120378_120573_-|hypothetical-protein
METFGWASATIAGLTCITWIASHVLDQIPVICHKAAKAIRSIRALRNEIRSEAREREGTTPNER
>NC_015951.1|WP_014043543.1|119637_120231_-|M15-family-metallopeptidase
MRLVDVRRDSRLLVDERKWQDSAGAFANLRKGVLDRLFKAQTLLPEGMRLLFVEGYRPPSLQRHYFDEYAHQLRTDHPDWSLEQVRSAASRYVSPPEIAPHSAGAAVDLTLADADGRELDMGTRMNATPEESADACYTQADNISGGARSHRDILSTALTTAGLVNYPTEWWHWSYGDRYWALMTGAETAHYGPRELD
>NC_015951.1|WP_014043542.1|118450_119407_+|NADP-dependent-oxidoreductase
MQEQRDQSPTDSSRAVRLESFGGPEVLDIRDIPAPQASPGQVRVRVTAAGLNPMDWFMTADADTAARFGLSLPAGFGTDYAGVVDQVGDGVTGFAPGDRVFGGALSRAVADFVVIEPAEGTAANEAHHTPGGVDDRTAATLTIAGRTASAALAVVDLGPDDTVLIGGAAGGVGVFAVQLARITGARVIGTGSATSAGFLRDLGAEPVAYGDGLADRVRTLAPSGVTAAIDLHGTETVHAARELGVPDGRICTIAAQVDGVPAANGANAAPGTLEGLARLVAAGQLRVPLAASFPIEQIRRAVELQADRHVKGKVVIDL
>NC_015951.1|WP_014043541.1|117785_118340_-|TetR/AcrR-family-transcriptional-regulator
MRSPRADATRNRDQLLAVATRMFASADAEPSMRAIAREAGVGIATLYRHFPTRESLVDAVYRDQVVRLTTGARELLGQLPPGAAMRRWMDMFGDWIATKNGMLDTLLAMIESGEIAHAQTRTELLAAITTILDAGSAAGDLRSDVTAEDIAASLIGIFTVAPRPEREAKASRLLNLLMDGLRPA
>NC_015951.1|WP_043242280.1|126302_127844_+|IS21-family-transposase
MEIFEALDATECAHSAAVLAGVDPKTVRRYARMRDTGRPISGPVVRPKLIDPFMPKIEEWVERSEGTVRADKLHERLRLLGFTGDERTTRRAVAKAKERWRSGHRRTYRPWITEPGLWLQFDWGWGPKVPGPGGGDTRETLLFCAWLAWSRYRVVIPVWDRTLPTVISCIDSTLRAIGGAPTYVLTDNEKTMTIDRVAGVAVRHPQVVAAGRHYGLQIHTCVPFDPESKGGSEATVRIAKADLIPTTANLREKYGDFAELRGACAIFCQQVNTRVYRETGKTPASALDIERTRLHPLPDAPHTLALGESRQVLRDQTVRFGSVRYSTPPGLVGQEAWVRADGEELVVVVDLSRLARRPEWMQGPAGLTEVARHPLSLPGRPVIDLSHYPGHPQEMDGSPRQPKPKPANDAERAFLALGPGAKSWLIEAGAAGTTRIRVKMAAAVELAALVGVAEVDISLGLAATAGRFAEDDLMSIVQHRRHGARPADLVVADEAHSVQPGTSAWADFGRKAT
>NC_015951.1|WP_050994194.1|128032_128758_+|ATP-binding-protein
MRFPYLRRAAPEVLATARSQRWDPAEVVRILLEEEIKGRDEATRRNHRKQAQLPSGKTFDSWREEDSSIPAPTLHALMTLEWISRAENLACAGPSGTGKSHLAEALANKAIDEGMKVSWFTLESLTAHLGRATVDSTVSKAVAKITRSDLIIVDDIGMLPSGQAAAEAFYCLIDAAYERRSVIVTSNLHPSGFDSIMPKTLATAAVDRLLHHAHVVLTEGSSLRLTQATTGQGVVPLSPTN
>NC_015951.1|WP_014043550.1|128769_129174_-|hypothetical-protein
MIPWNLLDLDSALRASWAADTCSPDDLARSGWQPENPAWGHCDITALIVNDVFGGDLMAGEVHSEGVQHGFHMWNRLASGIEIDLTREQFQRGRTVTEGRVVKRPPGPLRRWDEYLLLRKRVIERLGHLPEPAI
>NC_015951.1|WP_106686045.1|129860_130826_-|adenosine-deaminase
MDADIDLAFVRSLPKAELHVHLEGTLEPATALACARRNGVSLPWGSEEELRAAYDFADLPAFLEVLFRVAGTLRQRQDFFDLAMDYLRHVHADGVTRAEVFVGSQTFLDAGVPIEVILDGVLAAFREAGEEWGIDARLICTAQRHREESTALELLDLIEPWREQVIGIGMGSAERGNPPSKFARFFAEAQRRGYRTTIHAGEDAPASYVVEALELGVDRIDHGVAVADDPALIRRVADLGVPLTMCPLSNVALKVVPTLAAHPLKRLLDAGVVVTLNSDDPPFFGGYVADNYVASAAGLGLTRAELTRLAENSLASCWAPS
>NC_015951.1|WP_014043552.1|131420_131834_-|hypothetical-protein
MAHARSSDERHLLELLCLLPELEDKRFWNHILKLSGDGDWLDFNTQVREAVSAGRCCWVLSEVVLGLFGPSEYRAELARLIGSKQHTSGAFSDVDRRGVGEQWIQNAVSTAWRVWFSYARPQDKDPLEALKCKWNLD
>NC_015951.1|WP_167543318.1|131930_133388_-|site-specific-integrase
MPTSRRKPDTGGHPVRPRVNFRSELVFVRAFYQDIARWAADDPGRWAPWVAPCPIKASECATKKSRSGVKSRMDQRTRTQLPLLPALLRAVDQQRKDAENRITTAGATPAGERFLVAGQEFERCRSGQAHRVYATEVTTGRRRNLTHEEEAGFWSWATVEVLRHTGIRIEEMLELTHHSFIAYTLPTTGEVVPMLQVAPSKTDAERLLLVSPELAEVLTAVIFRVRAGNAALPLVSAYDVFEQTWGTPMPFLFQRRYGTEDRPLTRSYIRECLVATSQSAQITVAGDPLEWRPHDFRRIFVTDAIRSGLPPHIAAKICGHAALDTTMGYAAIYPEDVISHHRAFIARRRTERPSEEYRELTATEWDEFLSHFELRKVALGTCGRDYATPCQHENACVRCPLLLVDPAQMPRLQEIHANLIDRLQEARDQGWLGEVVAIETTLAAAAQKLEAMRDLTAKHTTVHLGMPDFRTTVGRLTPDPAEEGV
>NC_015951.1|WP_014043554.1|133487_133790_+|hypothetical-protein
MTAQPVDRHQPEPRVPRTIGGISEALRGARRAQFFAEVLAAEQGPELDATLTEWWGRAMLDSDPQRGRIHAAAEAGTLPTTSWDEIARRRRANGGAMPGE
>NC_015951.1|WP_014043555.1|133782_134055_+|hypothetical-protein
MSDEPRGLWPVAPSEAVGETLADPGLSAYLFSAVVALTVSIAEDPWLKGSTPLEGDDDWREVLILGGRGIAEYRINQDAHDVILTRILPF
>NC_015951.1|WP_043242286.1|134993_135254_-|hypothetical-protein
MPEDPIAHSELAALTRRFEQVDQKNDREFGIVKSDLTAVRLQVGNLDQKVGRLESRLEELGQKMDRNQAQIVELLTRLVGQDPNTG
>NC_015951.1|WP_014043557.1|135473_136298_-|hypothetical-protein
MTPRSLDELLADAEILQHEYDDEDTAASRLRIEREIADTWWRSALLLESSAQQVKPWLPEDAPRHRTPLCTAQHEQAAQDLRKLSTLVIRDSRAAHHIALLAQSCRAEPASALIFACLLHLADREGAQFWWQFSAGAGSATAALCLYLMHMQRGELRDAEHWAHEAACLEHLENQTSPHDDLVSLLRRPPSQGHRGSWYTPQSMINRTMAILHSGVAASTRVVDNPALADQPLCQSLAVAVQRLETKSDADYGTIPKASFELAARLEDCAAPSP

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_015951_2	2.1\|106975\|33\|NC_015951\|PILER-CR,CRT	106975-107007	33	NC_015957.1	4962248-4962280	1	0.97

1. spacer 2.1|106975|33|NC_015951|PILER-CR,CRT matches to position: 4962248-4962280, mismatch: 1, identity: 0.97

cgacagaagatcgccgacaccgccctgcggctc	CRISPR spacer
cgccagaagatcgccgacaccgccctgcggctc	Protospacer
** ******************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_015951_1	1.1\|104635\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	104635-104666	32	NC_015951	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence	104635-104666	0	1.0
NC_015951_1	1.2\|104696\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	104696-104727	32	NC_015951	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence	104696-104727	0	1.0
NC_015951_1	1.3\|104757\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	104757-104788	32	NC_015951	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence	104757-104788	0	1.0
NC_015951_1	1.4\|104818\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	104818-104849	32	NC_015951	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence	104818-104849	0	1.0
NC_015951_2	2.1\|106975\|33\|NC_015951\|PILER-CR,CRT	106975-107007	33	NC_015951	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence	106975-107007	0	1.0
NC_015951_2	2.2\|107037\|32\|NC_015951\|PILER-CR,CRT	107037-107068	32	NC_015951	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence	107037-107068	0	1.0
NC_015951_2	2.3\|107098\|32\|NC_015951\|PILER-CR,CRT	107098-107129	32	NC_015951	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence	107098-107129	0	1.0
NC_015951_2	2.3\|107098\|32\|NC_015951\|PILER-CR,CRT	107098-107129	32	NC_004719	Streptomyces avermitilis MA-4680 = NBRC 14893 plasmid SAP1, complete sequence	33271-33302	0	1.0
NC_015951_2	2.3\|107098\|32\|NC_015951\|PILER-CR,CRT	107098-107129	32	NZ_CP026654	Streptomyces dengpaensis strain XZHG99 plasmid unnamed2, complete sequence	62021-62052	0	1.0
NC_015951_2	2.4\|107159\|32\|NC_015951\|PILER-CR,CRT	107159-107190	32	NC_015951	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence	107159-107190	0	1.0
NC_015951_2	2.5\|107220\|32\|NC_015951\|PILER-CR,CRT	107220-107251	32	NC_015951	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence	107220-107251	0	1.0
NC_015951_2	2.6\|107281\|32\|NC_015951\|PILER-CR,CRT	107281-107312	32	NC_015951	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence	107281-107312	0	1.0
NC_015951_2	2.7\|106976\|32\|NC_015951\|CRISPRCasFinder	106976-107007	32	NC_015951	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence	106976-107007	0	1.0
NC_015951_2	2.8\|107038\|31\|NC_015951\|CRISPRCasFinder	107038-107068	31	NC_015951	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence	107038-107068	0	1.0
NC_015951_2	2.9\|107099\|31\|NC_015951\|CRISPRCasFinder	107099-107129	31	NC_015951	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence	107099-107129	0	1.0
NC_015951_2	2.9\|107099\|31\|NC_015951\|CRISPRCasFinder	107099-107129	31	NC_004719	Streptomyces avermitilis MA-4680 = NBRC 14893 plasmid SAP1, complete sequence	33271-33301	0	1.0
NC_015951_2	2.9\|107099\|31\|NC_015951\|CRISPRCasFinder	107099-107129	31	NZ_CP026654	Streptomyces dengpaensis strain XZHG99 plasmid unnamed2, complete sequence	62022-62052	0	1.0
NC_015951_2	2.10\|107160\|31\|NC_015951\|CRISPRCasFinder	107160-107190	31	NC_015951	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence	107160-107190	0	1.0
NC_015951_2	2.11\|107221\|31\|NC_015951\|CRISPRCasFinder	107221-107251	31	NC_015951	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence	107221-107251	0	1.0
NC_015951_2	2.12\|107282\|31\|NC_015951\|CRISPRCasFinder	107282-107312	31	NC_015951	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence	107282-107312	0	1.0
NC_015951_3	3.1\|116988\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	116988-117019	32	NC_015951	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence	116988-117019	0	1.0
NC_015951_3	3.2\|117049\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117049-117080	32	NC_015951	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence	117049-117080	0	1.0
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NC_015951	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence	117110-117141	0	1.0
NC_015951_3	3.4\|117171\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117171-117202	32	NC_015951	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence	117171-117202	0	1.0
NC_015951_3	3.5\|117232\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117232-117263	32	NC_015951	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence	117232-117263	0	1.0
NC_015951_3	3.6\|117293\|29\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117293-117321	29	NC_015951	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence	117293-117321	0	1.0
NC_015951_3	3.7\|117351\|32\|NC_015951\|CRISPRCasFinder,CRT	117351-117382	32	NC_015951	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence	117351-117382	0	1.0
NC_015951_3	3.8\|117412\|32\|NC_015951\|CRT	117412-117443	32	NC_015951	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence	117412-117443	0	1.0
NC_015951_3	3.9\|117473\|31\|NC_015951\|CRT	117473-117503	31	NC_015951	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence	117473-117503	0	1.0
NC_015951_4	4.1\|125630\|37\|NC_015951\|CRISPRCasFinder	125630-125666	37	NC_015951	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence	125630-125666	0	1.0
NC_015951_4	4.2\|125691\|37\|NC_015951\|CRISPRCasFinder	125691-125727	37	NC_015951	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence	125691-125727	0	1.0
NC_015951_4	4.3\|125752\|37\|NC_015951\|CRISPRCasFinder	125752-125788	37	NC_015951	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence	125752-125788	0	1.0
NC_015951_4	4.4\|125813\|37\|NC_015951\|CRISPRCasFinder	125813-125849	37	NC_015951	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence	125813-125849	0	1.0
NC_015951_4	4.5\|125874\|37\|NC_015951\|CRISPRCasFinder	125874-125910	37	NC_015951	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence	125874-125910	0	1.0
NC_015951_4	4.6\|125935\|35\|NC_015951\|CRISPRCasFinder	125935-125969	35	NC_015951	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence	125935-125969	0	1.0
NC_015951_4	4.7\|125994\|37\|NC_015951\|CRISPRCasFinder	125994-126030	37	NC_015951	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence	125994-126030	0	1.0
NC_015951_4	4.8\|126055\|38\|NC_015951\|CRISPRCasFinder	126055-126092	38	NC_015951	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence	126055-126092	0	1.0
NC_015951_2	2.1\|106975\|33\|NC_015951\|PILER-CR,CRT	106975-107007	33	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	1680850-1680882	1	0.97
NC_015951_2	2.1\|106975\|33\|NC_015951\|PILER-CR,CRT	106975-107007	33	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	132410-132442	1	0.97
NC_015951_2	2.7\|106976\|32\|NC_015951\|CRISPRCasFinder	106976-107007	32	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	1680851-1680882	1	0.969
NC_015951_2	2.7\|106976\|32\|NC_015951\|CRISPRCasFinder	106976-107007	32	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	132410-132441	1	0.969
NC_015951_2	2.3\|107098\|32\|NC_015951\|PILER-CR,CRT	107098-107129	32	NZ_CP025552	Streptomyces rimosus strain WT5260 plasmid unnamed, complete sequence	48552-48583	2	0.938
NC_015951_2	2.9\|107099\|31\|NC_015951\|CRISPRCasFinder	107099-107129	31	NZ_CP025552	Streptomyces rimosus strain WT5260 plasmid unnamed, complete sequence	48552-48582	2	0.935
NC_015951_4	4.5\|125874\|37\|NC_015951\|CRISPRCasFinder	125874-125910	37	NC_016972	Streptomyces hygroscopicus subsp. jinggangensis 5008 plasmid pSHJG2, complete sequence	38564-38600	4	0.892
NC_015951_3	3.1\|116988\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	116988-117019	32	NC_008043	Ruegeria sp. TM1040 megaplasmid, complete sequence	503309-503340	5	0.844
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NZ_CP035092	Paracoccus denitrificans strain ATCC 19367 plasmid unnamed1, complete sequence	446678-446709	5	0.844
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NC_008688	Paracoccus denitrificans PD1222 plasmid 1, complete sequence	40211-40242	5	0.844
NC_015951_3	3.6\|117293\|29\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117293-117321	29	NZ_CP016288	Rhizobium leguminosarum strain Vaf10 plasmid unnamed7, complete sequence	220402-220430	5	0.828
NC_015951_2	2.1\|106975\|33\|NC_015951\|PILER-CR,CRT	106975-107007	33	AM261282	Uncultured bacterium IncP-1 plasmid pKJK5 complete sequence	13821-13853	6	0.818
NC_015951_2	2.1\|106975\|33\|NC_015951\|PILER-CR,CRT	106975-107007	33	NZ_CP028340	Thauera aromatica K172 plasmid pKJK172, complete sequence	13042-13074	6	0.818
NC_015951_2	2.1\|106975\|33\|NC_015951\|PILER-CR,CRT	106975-107007	33	KC964605	Uncultured bacterium plasmid pMLUA1, complete sequence	13820-13852	6	0.818
NC_015951_2	2.1\|106975\|33\|NC_015951\|PILER-CR,CRT	106975-107007	33	KC964606	Uncultured bacterium plasmid pMLUA3, complete sequence	13820-13852	6	0.818
NC_015951_2	2.1\|106975\|33\|NC_015951\|PILER-CR,CRT	106975-107007	33	KC964607	Uncultured bacterium plasmid pMLUA4, complete sequence	13820-13852	6	0.818
NC_015951_2	2.1\|106975\|33\|NC_015951\|PILER-CR,CRT	106975-107007	33	JQ004406	Uncultured bacterium plasmid pHH128, complete sequence	4961-4993	6	0.818
NC_015951_2	2.1\|106975\|33\|NC_015951\|PILER-CR,CRT	106975-107007	33	JQ004407	Uncultured bacterium plasmid pHH3408, complete sequence	4963-4995	6	0.818
NC_015951_2	2.1\|106975\|33\|NC_015951\|PILER-CR,CRT	106975-107007	33	JQ004408	Uncultured bacterium plasmid pHH3414, complete sequence	4963-4995	6	0.818
NC_015951_2	2.1\|106975\|33\|NC_015951\|PILER-CR,CRT	106975-107007	33	JQ004409	Uncultured bacterium plasmid pKS77, complete sequence	4834-4866	6	0.818
NC_015951_2	2.1\|106975\|33\|NC_015951\|PILER-CR,CRT	106975-107007	33	NZ_MN366356	Bacterium plasmid pALTS27, complete sequence	12506-12538	6	0.818
NC_015951_2	2.1\|106975\|33\|NC_015951\|PILER-CR,CRT	106975-107007	33	NZ_MN366360	Bacterium plasmid pALTS32, complete sequence	12506-12538	6	0.818
NC_015951_2	2.7\|106976\|32\|NC_015951\|CRISPRCasFinder	106976-107007	32	NZ_CP015006	Aminobacter aminovorans strain KCTC 2477 plasmid pAA01, complete sequence	468239-468270	6	0.812
NC_015951_2	2.7\|106976\|32\|NC_015951\|CRISPRCasFinder	106976-107007	32	AM261282	Uncultured bacterium IncP-1 plasmid pKJK5 complete sequence	13821-13852	6	0.812
NC_015951_2	2.7\|106976\|32\|NC_015951\|CRISPRCasFinder	106976-107007	32	NZ_CP028340	Thauera aromatica K172 plasmid pKJK172, complete sequence	13042-13073	6	0.812
NC_015951_2	2.7\|106976\|32\|NC_015951\|CRISPRCasFinder	106976-107007	32	KC964605	Uncultured bacterium plasmid pMLUA1, complete sequence	13820-13851	6	0.812
NC_015951_2	2.7\|106976\|32\|NC_015951\|CRISPRCasFinder	106976-107007	32	KC964606	Uncultured bacterium plasmid pMLUA3, complete sequence	13820-13851	6	0.812
NC_015951_2	2.7\|106976\|32\|NC_015951\|CRISPRCasFinder	106976-107007	32	KC964607	Uncultured bacterium plasmid pMLUA4, complete sequence	13820-13851	6	0.812
NC_015951_2	2.7\|106976\|32\|NC_015951\|CRISPRCasFinder	106976-107007	32	JQ004406	Uncultured bacterium plasmid pHH128, complete sequence	4962-4993	6	0.812
NC_015951_2	2.7\|106976\|32\|NC_015951\|CRISPRCasFinder	106976-107007	32	JQ004407	Uncultured bacterium plasmid pHH3408, complete sequence	4964-4995	6	0.812
NC_015951_2	2.7\|106976\|32\|NC_015951\|CRISPRCasFinder	106976-107007	32	JQ004408	Uncultured bacterium plasmid pHH3414, complete sequence	4964-4995	6	0.812
NC_015951_2	2.7\|106976\|32\|NC_015951\|CRISPRCasFinder	106976-107007	32	JQ004409	Uncultured bacterium plasmid pKS77, complete sequence	4835-4866	6	0.812
NC_015951_2	2.7\|106976\|32\|NC_015951\|CRISPRCasFinder	106976-107007	32	NZ_MN366356	Bacterium plasmid pALTS27, complete sequence	12506-12537	6	0.812
NC_015951_2	2.7\|106976\|32\|NC_015951\|CRISPRCasFinder	106976-107007	32	NZ_MN366360	Bacterium plasmid pALTS32, complete sequence	12506-12537	6	0.812
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NZ_CP023408	Streptomyces fungicidicus strain TXX3120 plasmid p1, complete sequence	595389-595420	6	0.812
NC_015951_3	3.6\|117293\|29\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117293-117321	29	NZ_CP013052	Sinorhizobium americanum CCGM7 plasmid A, complete sequence	183445-183473	6	0.793
NC_015951_3	3.6\|117293\|29\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117293-117321	29	NZ_CP013110	Sinorhizobium americanum strain CFNEI 73 plasmid C, complete sequence	1541322-1541350	6	0.793
NC_015951_3	3.6\|117293\|29\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117293-117321	29	NZ_CP024308	Sinorhizobium fredii strain NXT3 plasmid pSfreNXT3a, complete sequence	255034-255062	6	0.793
NC_015951_3	3.6\|117293\|29\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117293-117321	29	NZ_CP050081	Rhizobium leguminosarum bv. trifolii strain 31B plasmid pRL31b5, complete sequence	257341-257369	6	0.793
NC_015951_3	3.6\|117293\|29\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117293-117321	29	NZ_CP049731	Rhizobium leguminosarum strain A1 plasmid pRL12, complete sequence	254014-254042	6	0.793
NC_015951_3	3.6\|117293\|29\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117293-117321	29	NZ_CP008954	Amycolatopsis japonica strain DSM 44213 plasmid pAmyja1, complete sequence	74940-74968	6	0.793
NC_015951_3	3.7\|117351\|32\|NC_015951\|CRISPRCasFinder,CRT	117351-117382	32	NZ_CP030772	Streptomyces sp. YIM 121038 plasmid pSSP121038, complete sequence	933750-933781	6	0.812
NC_015951_3	3.8\|117412\|32\|NC_015951\|CRT	117412-117443	32	NC_017327	Sinorhizobium meliloti SM11 plasmid pSmeSM11c, complete sequence	940968-940999	6	0.812
NC_015951_3	3.8\|117412\|32\|NC_015951\|CRT	117412-117443	32	NZ_CP021801	Sinorhizobium meliloti strain USDA1021 plasmid psymA, complete sequence	889590-889621	6	0.812
NC_015951_3	3.8\|117412\|32\|NC_015951\|CRT	117412-117443	32	NZ_CP021819	Sinorhizobium meliloti strain M162 plasmid psymA, complete sequence	751879-751910	6	0.812
NC_015951_3	3.8\|117412\|32\|NC_015951\|CRT	117412-117443	32	NZ_CP021830	Sinorhizobium meliloti strain HM006 plasmid psymA, complete sequence	387056-387087	6	0.812
NC_015951_3	3.8\|117412\|32\|NC_015951\|CRT	117412-117443	32	NC_018683	Sinorhizobium meliloti Rm41 plasmid pSYMA, complete sequence	812310-812341	6	0.812
NC_015951_3	3.8\|117412\|32\|NC_015951\|CRT	117412-117443	32	NZ_CP021809	Sinorhizobium meliloti strain Rm41 plasmid psymA, complete sequence	1362696-1362727	6	0.812
NC_015951_3	3.8\|117412\|32\|NC_015951\|CRT	117412-117443	32	NZ_CP021217	Sinorhizobium meliloti RU11/001 plasmid pSymA, complete sequence	527367-527398	6	0.812
NC_015951_3	3.8\|117412\|32\|NC_015951\|CRT	117412-117443	32	NZ_CP026526	Sinorhizobium meliloti strain AK21 plasmid pSymA, complete sequence	872601-872632	6	0.812
NC_015951_3	3.8\|117412\|32\|NC_015951\|CRT	117412-117443	32	NZ_CP019483	Sinorhizobium meliloti strain B401 plasmid pSymA, complete sequence	491182-491213	6	0.812
NC_015951_3	3.8\|117412\|32\|NC_015951\|CRT	117412-117443	32	NZ_CP019486	Sinorhizobium meliloti strain B399 plasmid pSymA, complete sequence	467003-467034	6	0.812
NC_015951_1	1.1\|104635\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	104635-104666	32	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	686890-686921	7	0.781
NC_015951_1	1.1\|104635\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	104635-104666	32	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	1126181-1126212	7	0.781
NC_015951_1	1.1\|104635\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	104635-104666	32	NZ_CP034153	Rhodococcus sp. NJ-530 plasmid unnamed1, complete sequence	84825-84856	7	0.781
NC_015951_1	1.2\|104696\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	104696-104727	32	KT001914	Caulobacter phage Seuss, complete genome	63139-63170	7	0.781
NC_015951_1	1.4\|104818\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	104818-104849	32	NZ_CP032685	Rhizobium sp. CCGE531 plasmid pRCCGE531d, complete sequence	1009887-1009918	7	0.781
NC_015951_1	1.4\|104818\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	104818-104849	32	NZ_CP032690	Rhizobium sp. CCGE532 plasmid pRCCGE532d, complete sequence	1010886-1010917	7	0.781
NC_015951_2	2.1\|106975\|33\|NC_015951\|PILER-CR,CRT	106975-107007	33	NZ_CP015006	Aminobacter aminovorans strain KCTC 2477 plasmid pAA01, complete sequence	468239-468271	7	0.788
NC_015951_2	2.4\|107159\|32\|NC_015951\|PILER-CR,CRT	107159-107190	32	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	929538-929569	7	0.781
NC_015951_2	2.7\|106976\|32\|NC_015951\|CRISPRCasFinder	106976-107007	32	NZ_CP010408	Streptomyces vietnamensis strain GIMV4.0001 plasmid pSVL1, complete sequence	275077-275108	7	0.781
NC_015951_2	2.7\|106976\|32\|NC_015951\|CRISPRCasFinder	106976-107007	32	NC_015178	Acidiphilium multivorum AIU301 plasmid pACMV1, complete sequence	66164-66195	7	0.781
NC_015951_2	2.10\|107160\|31\|NC_015951\|CRISPRCasFinder	107160-107190	31	NC_002575	Agrobacterium rhizogenes plasmid pRi1724 DNA, complete sequence	103161-103191	7	0.774
NC_015951_2	2.10\|107160\|31\|NC_015951\|CRISPRCasFinder	107160-107190	31	NZ_KY000038	Agrobacterium rhizogenes strain 1724 plasmid pRi_1724, complete sequence	150481-150511	7	0.774
NC_015951_2	2.12\|107282\|31\|NC_015951\|CRISPRCasFinder	107282-107312	31	NZ_CP023707	Edwardsiella tarda strain KC-Pc-HB1 plasmid pEh-Pc1, complete sequence	38520-38550	7	0.774
NC_015951_2	2.12\|107282\|31\|NC_015951\|CRISPRCasFinder	107282-107312	31	CP007644	Rhizobium etli bv. phaseoli str. IE4803 plasmid pRetIE4803c, complete sequence	392062-392092	7	0.774
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NZ_CP050104	Rhizobium leguminosarum bv. trifolii strain 4B plasmid pRL4b2, complete sequence	59679-59710	7	0.781
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NZ_CP013110	Sinorhizobium americanum strain CFNEI 73 plasmid C, complete sequence	2175171-2175202	7	0.781
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NZ_CP025507	Rhizobium leguminosarum bv. viciae strain UPM791 plasmid pRlvA, complete sequence	1040253-1040284	7	0.781
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NZ_CP050109	Rhizobium leguminosarum bv. trifolii strain 3B plasmid pRL3b2, complete sequence	59679-59710	7	0.781
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NZ_CP030761	Rhizobium leguminosarum strain ATCC 14479 plasmid unnamed1, complete sequence	547939-547970	7	0.781
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NZ_CP022666	Rhizobium leguminosarum bv. viciae strain BIHB 1217 plasmid pPR1, complete sequence	463790-463821	7	0.781
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NZ_CP050086	Rhizobium leguminosarum bv. trifolii strain 23B plasmid pRL23b7, complete sequence	59704-59735	7	0.781
NC_015951_3	3.4\|117171\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117171-117202	32	NZ_AP020327	Mycobacterium avium subsp. hominissuis strain JP-H-1 plasmid p1-JPH1	160899-160930	7	0.781
NC_015951_3	3.5\|117232\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117232-117263	32	NZ_CP039640	Azospirillum sp. TSH100 plasmid p1, complete sequence	165322-165353	7	0.781
NC_015951_3	3.5\|117232\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117232-117263	32	NC_016972	Streptomyces hygroscopicus subsp. jinggangensis 5008 plasmid pSHJG2, complete sequence	72979-73010	7	0.781
NC_015951_3	3.6\|117293\|29\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117293-117321	29	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	3191968-3191996	7	0.759
NC_015951_3	3.6\|117293\|29\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117293-117321	29	NZ_CP017943	Phyllobacterium zundukense strain Tri-48 plasmid unnamed2, complete sequence	286605-286633	7	0.759
NC_015951_3	3.6\|117293\|29\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117293-117321	29	NZ_CP029453	Sinorhizobium fredii CCBAU 25509 plasmid pSF25509a, complete sequence	198235-198263	7	0.759
NC_015951_3	3.6\|117293\|29\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117293-117321	29	NZ_CP007256	Rhodococcus erythropolis R138 plasmid pCRE138, complete sequence	37489-37517	7	0.759
NC_015951_3	3.6\|117293\|29\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117293-117321	29	NZ_CP023069	Ensifer sojae CCBAU 05684 plasmid pSJ05684a, complete sequence	214442-214470	7	0.759
NC_015951_3	3.6\|117293\|29\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117293-117321	29	NZ_CP023065	Sinorhizobium sp. CCBAU 05631 plasmid pSS05631a, complete sequence	166889-166917	7	0.759
NC_015951_3	3.6\|117293\|29\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117293-117321	29	NZ_CP029233	Sinorhizobium fredii CCBAU 45436 plasmid pSF45436a, complete sequence	216695-216723	7	0.759
NC_015951_3	3.6\|117293\|29\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117293-117321	29	NC_017958	Tistrella mobilis KA081020-065 plasmid pTM3, complete sequence	399020-399048	7	0.759
NC_015951_3	3.6\|117293\|29\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117293-117321	29	NZ_CP023072	Sinorhizobium fredii CCBAU 83666 plasmid pSF83666a, complete sequence	544861-544889	7	0.759
NC_015951_3	3.6\|117293\|29\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117293-117321	29	NC_000914	Sinorhizobium fredii NGR234 plasmid pNGR234a, complete sequence	411870-411898	7	0.759
NC_015951_3	3.6\|117293\|29\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117293-117321	29	NZ_CP009803	Streptomyces sp. FR-008 plasmid pSSFR1, complete sequence	74643-74671	7	0.759
NC_015951_3	3.8\|117412\|32\|NC_015951\|CRT	117412-117443	32	NZ_CP032695	Rhizobium jaguaris strain CCGE525 plasmid pRCCGE525c, complete sequence	1735924-1735955	7	0.781
NC_015951_3	3.9\|117473\|31\|NC_015951\|CRT	117473-117503	31	NZ_CP032695	Rhizobium jaguaris strain CCGE525 plasmid pRCCGE525c, complete sequence	2261370-2261400	7	0.774
NC_015951_1	1.1\|104635\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	104635-104666	32	NZ_CP032348	Azospirillum brasilense strain MTCC4039 plasmid p4, complete sequence	441111-441142	8	0.75
NC_015951_1	1.2\|104696\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	104696-104727	32	CP000876	Herpetosiphon aurantiacus DSM 785 plasmid pHAU01, complete sequence	139821-139852	8	0.75
NC_015951_2	2.1\|106975\|33\|NC_015951\|PILER-CR,CRT	106975-107007	33	NZ_CP010408	Streptomyces vietnamensis strain GIMV4.0001 plasmid pSVL1, complete sequence	275076-275108	8	0.758
NC_015951_2	2.4\|107159\|32\|NC_015951\|PILER-CR,CRT	107159-107190	32	NC_002575	Agrobacterium rhizogenes plasmid pRi1724 DNA, complete sequence	103161-103192	8	0.75
NC_015951_2	2.4\|107159\|32\|NC_015951\|PILER-CR,CRT	107159-107190	32	NZ_KY000038	Agrobacterium rhizogenes strain 1724 plasmid pRi_1724, complete sequence	150481-150512	8	0.75
NC_015951_2	2.6\|107281\|32\|NC_015951\|PILER-CR,CRT	107281-107312	32	CP007644	Rhizobium etli bv. phaseoli str. IE4803 plasmid pRetIE4803c, complete sequence	392062-392093	8	0.75
NC_015951_2	2.7\|106976\|32\|NC_015951\|CRISPRCasFinder	106976-107007	32	NZ_CP039640	Azospirillum sp. TSH100 plasmid p1, complete sequence	163891-163922	8	0.75
NC_015951_2	2.9\|107099\|31\|NC_015951\|CRISPRCasFinder	107099-107129	31	NZ_CP029831	Azospirillum ramasamyi strain M2T2B2 plasmid unnamed7, complete sequence	365217-365247	8	0.742
NC_015951_2	2.12\|107282\|31\|NC_015951\|CRISPRCasFinder	107282-107312	31	NZ_CP048281	Rhizobium leguminosarum bv. viciae 248 plasmid pRle248e, complete sequence	473831-473861	8	0.742
NC_015951_3	3.1\|116988\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	116988-117019	32	NZ_CP030074	Streptomyces sp. ZFG47 plasmid unnamed1, complete sequence	723325-723356	8	0.75
NC_015951_3	3.2\|117049\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117049-117080	32	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	588119-588150	8	0.75
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NZ_CP029777	Deinococcus actinosclerus strain Deinococcus actinosclerus SJTR plasmid unnamed3, complete sequence	377537-377568	8	0.75
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NZ_CP032828	Sphingomonas sp. YZ-8 plasmid unnamed1, complete sequence	523060-523091	8	0.75
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	194199-194230	8	0.75
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	1618918-1618949	8	0.75
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NZ_CP050081	Rhizobium leguminosarum bv. trifolii strain 31B plasmid pRL31b5, complete sequence	580844-580875	8	0.75
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NZ_CP015420	Rhodovulum sulfidophilum DSM 1374 plasmid unnamed2, complete sequence	38073-38104	8	0.75
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NZ_CP040819	Paraoceanicella profunda strain D4M1 plasmid pD4M1A, complete sequence	4269-4300	8	0.75
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NZ_CP040819	Paraoceanicella profunda strain D4M1 plasmid pD4M1A, complete sequence	584046-584077	8	0.75
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NZ_CP015882	Ensifer adhaerens strain Casida A plasmid pCasidaAB, complete sequence	1296358-1296389	8	0.75
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NZ_CP054022	Rhizobium sp. JKLM12A2 plasmid pPR12A201, complete sequence	498468-498499	8	0.75
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NZ_CP054026	Rhizobium sp. JKLM12A2 plasmid pPR12A205, complete sequence	201805-201836	8	0.75
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NZ_CP030264	Ensifer adhaerens strain Corn53 plasmid AB, complete sequence	1124526-1124557	8	0.75
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NZ_AP014801	Rhodovulum sulfidophilum plasmid Plasmid1 DNA, complete genome, strain: DSM 2351	48135-48166	8	0.75
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NZ_CP054036	Rhizobium sp. JKLM13E plasmid pPR13E05, complete sequence	43209-43240	8	0.75
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NC_020548	Azoarcus sp. KH32C plasmid pAZKH, complete sequence	736711-736742	8	0.75
NC_015951_3	3.4\|117171\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117171-117202	32	NZ_CP054613	Paenibacillus cellulosilyticus strain KACC 14175 plasmid unnamed4, complete sequence	2285572-2285603	8	0.75
NC_015951_3	3.4\|117171\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117171-117202	32	MH015258	Ruegeria phage vB_RpoS-V16, complete genome	12573-12604	8	0.75
NC_015951_3	3.4\|117171\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117171-117202	32	MH015249	Ruegeria phage vB_RpoS-V7, complete genome	10342-10373	8	0.75
NC_015951_3	3.4\|117171\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117171-117202	32	KM581061	Ruegeria phage DSS3-P1, complete genome	10366-10397	8	0.75
NC_015951_3	3.4\|117171\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117171-117202	32	HQ632855	Silicibacter phage DSS3-P1, * SEQUENCING IN PROGRESS *, 6 unordered pieces	44639-44670	8	0.75
NC_015951_3	3.4\|117171\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117171-117202	32	MH015254	Ruegeria phage vB_RpoS-V11, complete genome	9903-9934	8	0.75
NC_015951_3	3.4\|117171\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117171-117202	32	MH015252	Ruegeria phage vB_RpoS-V18, complete genome	10027-10058	8	0.75
NC_015951_3	3.5\|117232\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117232-117263	32	LC473083	Cutibacterium acnes TP-CU389 plasmid pTZC1 DNA, complete sequence	15220-15251	8	0.75
NC_015951_3	3.6\|117293\|29\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117293-117321	29	NC_012586	Sinorhizobium fredii NGR234 plasmid pNGR234b, complete sequence	1209764-1209792	8	0.724
NC_015951_3	3.6\|117293\|29\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117293-117321	29	NZ_CP007130	Gemmatirosa kalamazoonesis strain KBS708 plasmid 2, complete sequence	668230-668258	8	0.724
NC_015951_3	3.6\|117293\|29\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117293-117321	29	NC_010510	Methylobacterium radiotolerans JCM 2831 plasmid pMRAD01, complete sequence	54476-54504	8	0.724
NC_015951_3	3.6\|117293\|29\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117293-117321	29	NC_011879	Pseudarthrobacter chlorophenolicus A6 plasmid pACHL01, complete sequence	244546-244574	8	0.724
NC_015951_3	3.6\|117293\|29\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117293-117321	29	NZ_CP032685	Rhizobium sp. CCGE531 plasmid pRCCGE531d, complete sequence	1328382-1328410	8	0.724
NC_015951_3	3.6\|117293\|29\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117293-117321	29	NZ_CP032690	Rhizobium sp. CCGE532 plasmid pRCCGE532d, complete sequence	1330860-1330888	8	0.724
NC_015951_3	3.6\|117293\|29\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117293-117321	29	NZ_LR134463	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 21, complete sequence	95058-95086	8	0.724
NC_015951_3	3.6\|117293\|29\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117293-117321	29	NZ_CP013503	Rhizobium esperanzae strain N561 plasmid pRspN561c, complete sequence	340994-341022	8	0.724
NC_015951_3	3.6\|117293\|29\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117293-117321	29	NZ_CP013509	Rhizobium sp. N1341 plasmid pRspN1341d, complete sequence	340994-341022	8	0.724
NC_015951_3	3.6\|117293\|29\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117293-117321	29	NZ_CP013520	Rhizobium sp. N113 plasmid pRspN113c, complete sequence	340994-341022	8	0.724
NC_015951_3	3.6\|117293\|29\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117293-117321	29	NZ_CP013493	Rhizobium sp. N6212 plasmid pRspN6212c, complete sequence	340994-341022	8	0.724
NC_015951_3	3.6\|117293\|29\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117293-117321	29	NC_018853	Streptomyce phage TG1, complete genome	35618-35646	8	0.724
NC_015951_3	3.6\|117293\|29\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117293-117321	29	JX182372	Streptomyces virus TG1, complete genome	35618-35646	8	0.724
NC_015951_3	3.8\|117412\|32\|NC_015951\|CRT	117412-117443	32	NZ_AP014579	Burkholderia sp. RPE67 plasmid p1, complete sequence	400424-400455	8	0.75
NC_015951_3	3.8\|117412\|32\|NC_015951\|CRT	117412-117443	32	NC_016626	Burkholderia sp. YI23 plasmid byi_1p, complete sequence	242531-242562	8	0.75
NC_015951_3	3.8\|117412\|32\|NC_015951\|CRT	117412-117443	32	NZ_CP018472	Xanthomonas perforans strain LH3 plasmid pLH3.1, complete sequence	149250-149281	8	0.75
NC_015951_3	3.8\|117412\|32\|NC_015951\|CRT	117412-117443	32	NZ_CP023286	Xanthomonas citri pv. citri strain 03-1638-1-1 plasmid pCuR, complete sequence	211152-211183	8	0.75
NC_015951_3	3.8\|117412\|32\|NC_015951\|CRT	117412-117443	32	NZ_CP018859	Xanthomonas citri pv. citri strain LH201 plasmid pLH201.1, complete sequence	193281-193312	8	0.75
NC_015951_3	3.8\|117412\|32\|NC_015951\|CRT	117412-117443	32	NZ_CP018851	Xanthomonas citri pv. citri strain LJ207-7 plasmid pLJ207-7.1, complete sequence	157536-157567	8	0.75
NC_015951_3	3.8\|117412\|32\|NC_015951\|CRT	117412-117443	32	NZ_CP018848	Xanthomonas citri pv. citri strain LL074-4 plasmid pLL074-4.1, complete sequence	21699-21730	8	0.75
NC_015951_3	3.8\|117412\|32\|NC_015951\|CRT	117412-117443	32	NZ_CP018855	Xanthomonas citri pv. citri strain LH276 plasmid pLH276.1, complete sequence	8684-8715	8	0.75
NC_015951_3	3.8\|117412\|32\|NC_015951\|CRT	117412-117443	32	NZ_CP016287	Rhizobium leguminosarum strain Vaf10 plasmid unnamed1, complete sequence	947016-947047	8	0.75
NC_015951_3	3.8\|117412\|32\|NC_015951\|CRT	117412-117443	32	NZ_CP018729	Xanthomonas gardneri strain JS749-3 plasmid pJS749-3.1, complete sequence	8851-8882	8	0.75
NC_015951_3	3.8\|117412\|32\|NC_015951\|CRT	117412-117443	32	NZ_CP018732	Xanthomonas gardneri strain ICMP 7383 plasmid pICMP7383.1, complete sequence	107771-107802	8	0.75
NC_015951_1	1.2\|104696\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	104696-104727	32	NZ_CP035514	Haematobacter massiliensis strain OT1 plasmid pOT1-4, complete sequence	64845-64876	9	0.719
NC_015951_1	1.2\|104696\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	104696-104727	32	NZ_CP018784	Curtobacterium pusillum strain AA3 plasmid pCPAA3, complete sequence	333442-333473	9	0.719
NC_015951_1	1.2\|104696\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	104696-104727	32	NZ_CP012748	Paraburkholderia caribensis MBA4 plasmid unnamed, complete sequence	1226381-1226412	9	0.719
NC_015951_1	1.2\|104696\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	104696-104727	32	NZ_CP012399	Chelatococcus sp. CO-6 plasmid pCO-6, complete sequence	748666-748697	9	0.719
NC_015951_2	2.1\|106975\|33\|NC_015951\|PILER-CR,CRT	106975-107007	33	NZ_CP039640	Azospirillum sp. TSH100 plasmid p1, complete sequence	163891-163923	9	0.727
NC_015951_2	2.3\|107098\|32\|NC_015951\|PILER-CR,CRT	107098-107129	32	NZ_CP029831	Azospirillum ramasamyi strain M2T2B2 plasmid unnamed7, complete sequence	365216-365247	9	0.719
NC_015951_2	2.5\|107220\|32\|NC_015951\|PILER-CR,CRT	107220-107251	32	KX077895	Streptococcus phage phiZJ20091101-4, complete genome	27203-27234	9	0.719
NC_015951_2	2.6\|107281\|32\|NC_015951\|PILER-CR,CRT	107281-107312	32	NZ_CP048281	Rhizobium leguminosarum bv. viciae 248 plasmid pRle248e, complete sequence	473830-473861	9	0.719
NC_015951_2	2.7\|106976\|32\|NC_015951\|CRISPRCasFinder	106976-107007	32	NZ_CP029831	Azospirillum ramasamyi strain M2T2B2 plasmid unnamed7, complete sequence	473004-473035	9	0.719
NC_015951_2	2.7\|106976\|32\|NC_015951\|CRISPRCasFinder	106976-107007	32	NZ_CP006368	Aureimonas sp. AU20 plasmid pAU20a, complete sequence	233373-233404	9	0.719
NC_015951_2	2.7\|106976\|32\|NC_015951\|CRISPRCasFinder	106976-107007	32	NZ_CP029542	Streptomyces sp. NEAU-S7GS2 plasmid unnamed1, complete sequence	9188-9219	9	0.719
NC_015951_2	2.7\|106976\|32\|NC_015951\|CRISPRCasFinder	106976-107007	32	NZ_CP041606	Streptomyces sp. S1D4-14 plasmid pS1D4-14.2, complete sequence	82984-83015	9	0.719
NC_015951_2	2.8\|107038\|31\|NC_015951\|CRISPRCasFinder	107038-107068	31	MN096370	Gordonia phage Squiddly, complete genome	23461-23491	9	0.71
NC_015951_2	2.8\|107038\|31\|NC_015951\|CRISPRCasFinder	107038-107068	31	MK937597	Gordonia phage Spooky, complete genome	22049-22079	9	0.71
NC_015951_2	2.11\|107221\|31\|NC_015951\|CRISPRCasFinder	107221-107251	31	KX077895	Streptococcus phage phiZJ20091101-4, complete genome	27204-27234	9	0.71
NC_015951_3	3.1\|116988\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	116988-117019	32	MN224564	Streptomyces phage Araceli, complete genome	17541-17572	9	0.719
NC_015951_3	3.1\|116988\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	116988-117019	32	MH229863	Streptomyces phage JackieB, complete genome	17406-17437	9	0.719
NC_015951_3	3.1\|116988\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	116988-117019	32	MH229862	Streptomyces phage Henoccus, complete genome	17551-17582	9	0.719
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NC_009469	Acidiphilium cryptum JF-5 plasmid pACRY03, complete sequence	27721-27752	9	0.719
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NC_012586	Sinorhizobium fredii NGR234 plasmid pNGR234b, complete sequence	2428033-2428064	9	0.719
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NC_012586	Sinorhizobium fredii NGR234 plasmid pNGR234b, complete sequence	2122339-2122370	9	0.719
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NZ_CP017563	Paraburkholderia sprentiae WSM5005 plasmid pl1WSM5005, complete sequence	766162-766193	9	0.719
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NZ_CP029232	Sinorhizobium fredii CCBAU 45436 plasmid pSF45436b, complete sequence	1957430-1957461	9	0.719
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NZ_CP015881	Ensifer adhaerens strain Casida A plasmid pCasidaAA, complete sequence	469926-469957	9	0.719
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NZ_CP030263	Ensifer adhaerens strain Corn53 plasmid AA, complete sequence	1747507-1747538	9	0.719
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NZ_CP023068	Ensifer sojae CCBAU 05684 plasmid pSJ05684b, complete sequence	117754-117785	9	0.719
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NZ_CP054620	Azospirillum oryzae strain KACC 14407 plasmid unnamed5, complete sequence	52863-52894	9	0.719
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NZ_CP023738	Methylosinus trichosporium OB3b plasmid pOB3b1, complete sequence	13687-13718	9	0.719
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	MN234195	Mycobacterium phage Xula, complete genome	40154-40185	9	0.719
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	MH744423	Mycobacterium phage Saguaro, complete genome	20732-20763	9	0.719
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NC_023498	Mycobacterium phage Validus, complete genome	7210-7241	9	0.719
NC_015951_3	3.5\|117232\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117232-117263	32	MN813687	Mycobacterium phage Onyinye, complete genome	17324-17355	9	0.719
NC_015951_3	3.5\|117232\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117232-117263	32	NZ_CP032827	Sphingomonas sp. YZ-8 plasmid unnamed2, complete sequence	190040-190071	9	0.719
NC_015951_3	3.5\|117232\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117232-117263	32	NZ_CP006990	Rhizobium sp. IE4771 plasmid pRetIE4771d, complete sequence	256281-256312	9	0.719
NC_015951_3	3.7\|117351\|32\|NC_015951\|CRISPRCasFinder,CRT	117351-117382	32	NZ_CP013855	Pseudonocardia sp. HH130630-07 plasmid pLS2-1, complete sequence	326205-326236	9	0.719
NC_015951_3	3.7\|117351\|32\|NC_015951\|CRISPRCasFinder,CRT	117351-117382	32	NZ_CP011869	Pseudonocardia sp. HH130629-09 plasmid pLS1-1, complete sequence	192752-192783	9	0.719
NC_015951_3	3.8\|117412\|32\|NC_015951\|CRT	117412-117443	32	NC_016115	Streptomyces pratensis ATCC 33331 plasmid pSFLA02, complete sequence	60544-60575	9	0.719
NC_015951_3	3.8\|117412\|32\|NC_015951\|CRT	117412-117443	32	NZ_CP018726	Xanthomonas vesicatoria ATCC 35937 strain LMG911 plasmid pLMG911.1, complete sequence	654-685	9	0.719
NC_015951_3	3.9\|117473\|31\|NC_015951\|CRT	117473-117503	31	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	4904771-4904801	9	0.71
NC_015951_4	4.6\|125935\|35\|NC_015951\|CRISPRCasFinder	125935-125969	35	NZ_CP024424	Paracoccus yeei strain TT13 plasmid pTT13-2, complete sequence	176144-176178	9	0.743
NC_015951_4	4.6\|125935\|35\|NC_015951\|CRISPRCasFinder	125935-125969	35	NZ_CP020440	Paracoccus yeei strain FDAARGOS_252 plasmid unnamed2, complete sequence	58195-58229	9	0.743
NC_015951_4	4.6\|125935\|35\|NC_015951\|CRISPRCasFinder	125935-125969	35	NZ_CP044082	Paracoccus yeei strain FDAARGOS_643 plasmid unnamed4, complete sequence	264480-264514	9	0.743
NC_015951_1	1.1\|104635\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	104635-104666	32	NZ_CP025962	Rhodococcus qingshengii strain djl-6-2 plasmid pDJL3, complete sequence	991-1022	10	0.688
NC_015951_1	1.2\|104696\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	104696-104727	32	NZ_CP033873	Caulobacter sp. FWC26 plasmid p1, complete sequence	224849-224880	10	0.688
NC_015951_1	1.4\|104818\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	104818-104849	32	NZ_CP015095	Pelagibaca abyssi strain JLT2014 plasmid pPABY4, complete sequence	17164-17195	10	0.688
NC_015951_1	1.4\|104818\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	104818-104849	32	NZ_CP029834	Azospirillum ramasamyi strain M2T2B2 plasmid unnamed4, complete sequence	199507-199538	10	0.688
NC_015951_1	1.4\|104818\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	104818-104849	32	NZ_CP040822	Paraoceanicella profunda strain D4M1 plasmid pD4M1D, complete sequence	106427-106458	10	0.688
NC_015951_2	2.2\|107037\|32\|NC_015951\|PILER-CR,CRT	107037-107068	32	MN096370	Gordonia phage Squiddly, complete genome	23460-23491	10	0.688
NC_015951_2	2.2\|107037\|32\|NC_015951\|PILER-CR,CRT	107037-107068	32	MK937597	Gordonia phage Spooky, complete genome	22048-22079	10	0.688
NC_015951_2	2.7\|106976\|32\|NC_015951\|CRISPRCasFinder	106976-107007	32	NZ_CP013855	Pseudonocardia sp. HH130630-07 plasmid pLS2-1, complete sequence	80810-80841	10	0.688
NC_015951_2	2.7\|106976\|32\|NC_015951\|CRISPRCasFinder	106976-107007	32	NZ_CP029777	Deinococcus actinosclerus strain Deinococcus actinosclerus SJTR plasmid unnamed3, complete sequence	21068-21099	10	0.688
NC_015951_2	2.7\|106976\|32\|NC_015951\|CRISPRCasFinder	106976-107007	32	MH727545	Mycobacterium phage DismalStressor, complete genome	4106-4137	10	0.688
NC_015951_2	2.7\|106976\|32\|NC_015951\|CRISPRCasFinder	106976-107007	32	NC_026598	Mycobacterium phage Milly, complete genome	4106-4137	10	0.688
NC_015951_2	2.7\|106976\|32\|NC_015951\|CRISPRCasFinder	106976-107007	32	KX688047	Mycobacterium phage Marcoliusprime, complete genome	4106-4137	10	0.688
NC_015951_2	2.7\|106976\|32\|NC_015951\|CRISPRCasFinder	106976-107007	32	MF140408	Mycobacterium phage DismalFunk, complete genome	4106-4137	10	0.688
NC_015951_2	2.7\|106976\|32\|NC_015951\|CRISPRCasFinder	106976-107007	32	MF140411	Mycobacterium phage Findley, complete genome	4106-4137	10	0.688
NC_015951_3	3.2\|117049\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117049-117080	32	NZ_CP035424	Leisingera sp. NJS204 plasmid unnamed7, complete sequence	10593-10624	10	0.688
NC_015951_3	3.2\|117049\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117049-117080	32	NZ_CP026091	Ralstonia solanacearum strain IBSBF 2570 plasmid unnamed, complete sequence	1383419-1383450	10	0.688
NC_015951_3	3.2\|117049\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117049-117080	32	NC_014309	Ralstonia solanacearum CFBP2957 plasmid RCFBPv3_mp, complete genome	1132875-1132906	10	0.688
NC_015951_3	3.2\|117049\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117049-117080	32	NZ_CP038236	Leisingera sp. NJS201 plasmid unnamed2, complete sequence	26158-26189	10	0.688
NC_015951_3	3.2\|117049\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117049-117080	32	NZ_CP026093	Ralstonia solanacearum strain SFC plasmid unnamed, complete sequence	1383572-1383603	10	0.688
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NC_016586	Azospirillum lipoferum 4B plasmid AZO_p2, complete sequence	145447-145478	10	0.688
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NZ_CP032326	Azospirillum brasilense strain MTCC4035 plasmid p5, complete sequence	95218-95249	10	0.688
NC_015951_3	3.3\|117110\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117110-117141	32	NC_030931	Pseudomonas phage phi2, complete genome	18988-19019	10	0.688
NC_015951_3	3.4\|117171\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117171-117202	32	NZ_CP011515	Mitsuaria sp. 7 plasmid, complete sequence	13043-13074	10	0.688
NC_015951_3	3.5\|117232\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117232-117263	32	NZ_CP053440	Rhizobium leguminosarum bv. trifolii strain CC275e plasmid pRltCC275eF, complete sequence	402388-402419	10	0.688
NC_015951_3	3.5\|117232\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117232-117263	32	NZ_CP054028	Rhizobium sp. JKLM19E plasmid pPR19E01, complete sequence	539584-539615	10	0.688
NC_015951_3	3.5\|117232\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117232-117263	32	NC_009620	Sinorhizobium medicae WSM419 plasmid pSMED01, complete sequence	916162-916193	10	0.688
NC_015951_3	3.5\|117232\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	117232-117263	32	NC_047890	Escherichia phage PGT2, complete genome	20663-20694	10	0.688
NC_015951_3	3.8\|117412\|32\|NC_015951\|CRT	117412-117443	32	NZ_CP032053	Streptomyces clavuligerus strain F1D-5 plasmid pSCL2, complete sequence	69462-69493	10	0.688
NC_015951_3	3.8\|117412\|32\|NC_015951\|CRT	117412-117443	32	NZ_CP032053	Streptomyces clavuligerus strain F1D-5 plasmid pSCL2, complete sequence	86301-86332	10	0.688
NC_015951_3	3.8\|117412\|32\|NC_015951\|CRT	117412-117443	32	NZ_CP023408	Streptomyces fungicidicus strain TXX3120 plasmid p1, complete sequence	260294-260325	10	0.688
NC_015951_4	4.1\|125630\|37\|NC_015951\|CRISPRCasFinder	125630-125666	37	NZ_CP029832	Azospirillum ramasamyi strain M2T2B2 plasmid unnamed2, complete sequence	407150-407186	10	0.73
NC_015951_1	1.2\|104696\|32\|NC_015951\|PILER-CR,CRISPRCasFinder,CRT	104696-104727	32	NZ_AP014705	Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence	1478200-1478231	11	0.656

1. spacer 1.1|104635|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NC_015951 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence) position: , mismatch: 0, identity: 1.0

taccgcgccgtcaccggggccaccccgaactg	CRISPR spacer
taccgcgccgtcaccggggccaccccgaactg	Protospacer
********************************

2. spacer 1.2|104696|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NC_015951 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence) position: , mismatch: 0, identity: 1.0

cacatcgcgctcgcgccccgcacgagcagcac	CRISPR spacer
cacatcgcgctcgcgccccgcacgagcagcac	Protospacer
********************************

3. spacer 1.3|104757|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NC_015951 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence) position: , mismatch: 0, identity: 1.0

ttgttcgcagcacggacggctttgttgagttc	CRISPR spacer
ttgttcgcagcacggacggctttgttgagttc	Protospacer
********************************

4. spacer 1.4|104818|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NC_015951 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence) position: , mismatch: 0, identity: 1.0

tccgcaggtcggccccgtggtcaacggtcaga	CRISPR spacer
tccgcaggtcggccccgtggtcaacggtcaga	Protospacer
********************************

5. spacer 2.1|106975|33|NC_015951|PILER-CR,CRT matches to NC_015951 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence) position: , mismatch: 0, identity: 1.0

cgacagaagatcgccgacaccgccctgcggctc	CRISPR spacer
cgacagaagatcgccgacaccgccctgcggctc	Protospacer
*********************************

6. spacer 2.2|107037|32|NC_015951|PILER-CR,CRT matches to NC_015951 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence) position: , mismatch: 0, identity: 1.0

acgaaaacagcacccgcctgggcggtggtgac	CRISPR spacer
acgaaaacagcacccgcctgggcggtggtgac	Protospacer
********************************

7. spacer 2.3|107098|32|NC_015951|PILER-CR,CRT matches to NC_015951 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence) position: , mismatch: 0, identity: 1.0

ctgtcccatccgcacatcgtcaccgtgcacga	CRISPR spacer
ctgtcccatccgcacatcgtcaccgtgcacga	Protospacer
********************************

8. spacer 2.3|107098|32|NC_015951|PILER-CR,CRT matches to NC_004719 (Streptomyces avermitilis MA-4680 = NBRC 14893 plasmid SAP1, complete sequence) position: , mismatch: 0, identity: 1.0

ctgtcccatccgcacatcgtcaccgtgcacga	CRISPR spacer
ctgtcccatccgcacatcgtcaccgtgcacga	Protospacer
********************************

9. spacer 2.3|107098|32|NC_015951|PILER-CR,CRT matches to NZ_CP026654 (Streptomyces dengpaensis strain XZHG99 plasmid unnamed2, complete sequence) position: , mismatch: 0, identity: 1.0

ctgtcccatccgcacatcgtcaccgtgcacga	CRISPR spacer
ctgtcccatccgcacatcgtcaccgtgcacga	Protospacer
********************************

10. spacer 2.4|107159|32|NC_015951|PILER-CR,CRT matches to NC_015951 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence) position: , mismatch: 0, identity: 1.0

cgggaccaggtccgctgggcgaggtccccggc	CRISPR spacer
cgggaccaggtccgctgggcgaggtccccggc	Protospacer
********************************

11. spacer 2.5|107220|32|NC_015951|PILER-CR,CRT matches to NC_015951 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence) position: , mismatch: 0, identity: 1.0

tcgggggtccaccgctggacgcccttgccagc	CRISPR spacer
tcgggggtccaccgctggacgcccttgccagc	Protospacer
********************************

12. spacer 2.6|107281|32|NC_015951|PILER-CR,CRT matches to NC_015951 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence) position: , mismatch: 0, identity: 1.0

catcagcaagatcctggagacgcccgacgggg	CRISPR spacer
catcagcaagatcctggagacgcccgacgggg	Protospacer
********************************

13. spacer 2.7|106976|32|NC_015951|CRISPRCasFinder matches to NC_015951 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence) position: , mismatch: 0, identity: 1.0

gacagaagatcgccgacaccgccctgcggctc	CRISPR spacer
gacagaagatcgccgacaccgccctgcggctc	Protospacer
********************************

14. spacer 2.8|107038|31|NC_015951|CRISPRCasFinder matches to NC_015951 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence) position: , mismatch: 0, identity: 1.0

cgaaaacagcacccgcctgggcggtggtgac	CRISPR spacer
cgaaaacagcacccgcctgggcggtggtgac	Protospacer
*******************************

15. spacer 2.9|107099|31|NC_015951|CRISPRCasFinder matches to NC_015951 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence) position: , mismatch: 0, identity: 1.0

tgtcccatccgcacatcgtcaccgtgcacga	CRISPR spacer
tgtcccatccgcacatcgtcaccgtgcacga	Protospacer
*******************************

16. spacer 2.9|107099|31|NC_015951|CRISPRCasFinder matches to NC_004719 (Streptomyces avermitilis MA-4680 = NBRC 14893 plasmid SAP1, complete sequence) position: , mismatch: 0, identity: 1.0

tgtcccatccgcacatcgtcaccgtgcacga	CRISPR spacer
tgtcccatccgcacatcgtcaccgtgcacga	Protospacer
*******************************

17. spacer 2.9|107099|31|NC_015951|CRISPRCasFinder matches to NZ_CP026654 (Streptomyces dengpaensis strain XZHG99 plasmid unnamed2, complete sequence) position: , mismatch: 0, identity: 1.0

tgtcccatccgcacatcgtcaccgtgcacga	CRISPR spacer
tgtcccatccgcacatcgtcaccgtgcacga	Protospacer
*******************************

18. spacer 2.10|107160|31|NC_015951|CRISPRCasFinder matches to NC_015951 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence) position: , mismatch: 0, identity: 1.0

gggaccaggtccgctgggcgaggtccccggc	CRISPR spacer
gggaccaggtccgctgggcgaggtccccggc	Protospacer
*******************************

19. spacer 2.11|107221|31|NC_015951|CRISPRCasFinder matches to NC_015951 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence) position: , mismatch: 0, identity: 1.0

cgggggtccaccgctggacgcccttgccagc	CRISPR spacer
cgggggtccaccgctggacgcccttgccagc	Protospacer
*******************************

20. spacer 2.12|107282|31|NC_015951|CRISPRCasFinder matches to NC_015951 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence) position: , mismatch: 0, identity: 1.0

atcagcaagatcctggagacgcccgacgggg	CRISPR spacer
atcagcaagatcctggagacgcccgacgggg	Protospacer
*******************************

21. spacer 3.1|116988|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NC_015951 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence) position: , mismatch: 0, identity: 1.0

tcagcaggatcgtcacgagcccggtccatgcc	CRISPR spacer
tcagcaggatcgtcacgagcccggtccatgcc	Protospacer
********************************

22. spacer 3.2|117049|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NC_015951 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence) position: , mismatch: 0, identity: 1.0

gagatggccaagggcgggcagccccaggcgat	CRISPR spacer
gagatggccaagggcgggcagccccaggcgat	Protospacer
********************************

23. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NC_015951 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence) position: , mismatch: 0, identity: 1.0

caccacatcgacgaggcgacggtggcggcgag	CRISPR spacer
caccacatcgacgaggcgacggtggcggcgag	Protospacer
********************************

24. spacer 3.4|117171|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NC_015951 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence) position: , mismatch: 0, identity: 1.0

ggtgccggtcgcgtggttgatctggcggatgg	CRISPR spacer
ggtgccggtcgcgtggttgatctggcggatgg	Protospacer
********************************

25. spacer 3.5|117232|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NC_015951 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence) position: , mismatch: 0, identity: 1.0

ccgcactggaagaccagcgcctggaccgcctc	CRISPR spacer
ccgcactggaagaccagcgcctggaccgcctc	Protospacer
********************************

26. spacer 3.6|117293|29|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NC_015951 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence) position: , mismatch: 0, identity: 1.0

caaggggtgccgaccggcggcggcgacgt	CRISPR spacer
caaggggtgccgaccggcggcggcgacgt	Protospacer
*****************************

27. spacer 3.7|117351|32|NC_015951|CRISPRCasFinder,CRT matches to NC_015951 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence) position: , mismatch: 0, identity: 1.0

aatcgggacccccgcgaccgtgcgaccggccc	CRISPR spacer
aatcgggacccccgcgaccgtgcgaccggccc	Protospacer
********************************

28. spacer 3.8|117412|32|NC_015951|CRT matches to NC_015951 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence) position: , mismatch: 0, identity: 1.0

ttcatcgcggcgaccaagaacgccgccgctca	CRISPR spacer
ttcatcgcggcgaccaagaacgccgccgctca	Protospacer
********************************

29. spacer 3.9|117473|31|NC_015951|CRT matches to NC_015951 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence) position: , mismatch: 0, identity: 1.0

cgcgctcggtgtacttggggccctcgccggg	CRISPR spacer
cgcgctcggtgtacttggggccctcgccggg	Protospacer
*******************************

30. spacer 4.1|125630|37|NC_015951|CRISPRCasFinder matches to NC_015951 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence) position: , mismatch: 0, identity: 1.0

catctgaccggaggcgcccagtgaccgcaggcgtcct	CRISPR spacer
catctgaccggaggcgcccagtgaccgcaggcgtcct	Protospacer
*************************************

31. spacer 4.2|125691|37|NC_015951|CRISPRCasFinder matches to NC_015951 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence) position: , mismatch: 0, identity: 1.0

ttgccccacacgttgccgtcggcgtatctgacgtcct	CRISPR spacer
ttgccccacacgttgccgtcggcgtatctgacgtcct	Protospacer
*************************************

32. spacer 4.3|125752|37|NC_015951|CRISPRCasFinder matches to NC_015951 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence) position: , mismatch: 0, identity: 1.0

tgctggccgatcatgtgacgccagatcgcgcggggcc	CRISPR spacer
tgctggccgatcatgtgacgccagatcgcgcggggcc	Protospacer
*************************************

33. spacer 4.4|125813|37|NC_015951|CRISPRCasFinder matches to NC_015951 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence) position: , mismatch: 0, identity: 1.0

gtctgacgtcccttggaggggtggcaggcccagtgct	CRISPR spacer
gtctgacgtcccttggaggggtggcaggcccagtgct	Protospacer
*************************************

34. spacer 4.5|125874|37|NC_015951|CRISPRCasFinder matches to NC_015951 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence) position: , mismatch: 0, identity: 1.0

aagcacgacgcggtgacgcgtgagcagctgctgtgct	CRISPR spacer
aagcacgacgcggtgacgcgtgagcagctgctgtgct	Protospacer
*************************************

35. spacer 4.6|125935|35|NC_015951|CRISPRCasFinder matches to NC_015951 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence) position: , mismatch: 0, identity: 1.0

ttccgtggggtcaaggacgaccagggcctgccgtg	CRISPR spacer
ttccgtggggtcaaggacgaccagggcctgccgtg	Protospacer
***********************************

36. spacer 4.7|125994|37|NC_015951|CRISPRCasFinder matches to NC_015951 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence) position: , mismatch: 0, identity: 1.0

gtgccatccatcactgcgtaggcgtcgcaccggtgct	CRISPR spacer
gtgccatccatcactgcgtaggcgtcgcaccggtgct	Protospacer
*************************************

37. spacer 4.8|126055|38|NC_015951|CRISPRCasFinder matches to NC_015951 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence) position: , mismatch: 0, identity: 1.0

ctgaccgtcgacacgggtatcgcccacagtcaggcctt	CRISPR spacer
ctgaccgtcgacacgggtatcgcccacagtcaggcctt	Protospacer
**************************************

38. spacer 2.1|106975|33|NC_015951|PILER-CR,CRT matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 1, identity: 0.97

cgacagaagatcgccgacaccgccctgcggctc	CRISPR spacer
cgccagaagatcgccgacaccgccctgcggctc	Protospacer
** ******************************

39. spacer 2.1|106975|33|NC_015951|PILER-CR,CRT matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 1, identity: 0.97

cgacagaagatcgccgacaccgccctgcggctc	CRISPR spacer
cgccagaagatcgccgacaccgccctgcggctc	Protospacer
** ******************************

40. spacer 2.7|106976|32|NC_015951|CRISPRCasFinder matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 1, identity: 0.969

gacagaagatcgccgacaccgccctgcggctc	CRISPR spacer
gccagaagatcgccgacaccgccctgcggctc	Protospacer
* ******************************

41. spacer 2.7|106976|32|NC_015951|CRISPRCasFinder matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 1, identity: 0.969

gacagaagatcgccgacaccgccctgcggctc	CRISPR spacer
gccagaagatcgccgacaccgccctgcggctc	Protospacer
* ******************************

42. spacer 2.3|107098|32|NC_015951|PILER-CR,CRT matches to NZ_CP025552 (Streptomyces rimosus strain WT5260 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.938

ctgtcccatccgcacatcgtcaccgtgcacga	CRISPR spacer
ctgtcccacccacacatcgtcaccgtgcacga	Protospacer
********.**.********************

43. spacer 2.9|107099|31|NC_015951|CRISPRCasFinder matches to NZ_CP025552 (Streptomyces rimosus strain WT5260 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.935

tgtcccatccgcacatcgtcaccgtgcacga	CRISPR spacer
tgtcccacccacacatcgtcaccgtgcacga	Protospacer
*******.**.********************

44. spacer 4.5|125874|37|NC_015951|CRISPRCasFinder matches to NC_016972 (Streptomyces hygroscopicus subsp. jinggangensis 5008 plasmid pSHJG2, complete sequence) position: , mismatch: 4, identity: 0.892

aagcacgacgcggtgacgcgtgagcagctgctgtgct	CRISPR spacer
aagcacgacgcggtgacgcgcgagcagctgctggccc	Protospacer
********************.************  *.

45. spacer 3.1|116988|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NC_008043 (Ruegeria sp. TM1040 megaplasmid, complete sequence) position: , mismatch: 5, identity: 0.844

tcagcaggatcgtcacgagcccggtccatgcc	CRISPR spacer
acagcaggatcgtcacgggccaggtccaggtc	Protospacer
 ****************.*** ****** *.*

46. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP035092 (Paracoccus denitrificans strain ATCC 19367 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.844

caccacatcgacgaggcgacggtggcggcgag	CRISPR spacer
cgcatcatcgaccaggcggcggtggcggcgag	Protospacer
*.*  ******* *****.*************

47. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NC_008688 (Paracoccus denitrificans PD1222 plasmid 1, complete sequence) position: , mismatch: 5, identity: 0.844

caccacatcgacgaggcgacggtggcggcgag	CRISPR spacer
cgcatcatcgaccaggcggcggtggcggcgag	Protospacer
*.*  ******* *****.*************

48. spacer 3.6|117293|29|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP016288 (Rhizobium leguminosarum strain Vaf10 plasmid unnamed7, complete sequence) position: , mismatch: 5, identity: 0.828

caaggggtgccgaccggcggcggcgacgt	CRISPR spacer
aaagtggtggcgaccggcggcggcgcctt	Protospacer
 *** **** *************** * *

49. spacer 2.1|106975|33|NC_015951|PILER-CR,CRT matches to AM261282 (Uncultured bacterium IncP-1 plasmid pKJK5 complete sequence) position: , mismatch: 6, identity: 0.818

cgacagaagatcgccgacaccgccctgcggctc--	CRISPR spacer
cgacataagatcgccgccaccgcc--gccgcttga	Protospacer
***** ********** *******  ** ***.

50. spacer 2.1|106975|33|NC_015951|PILER-CR,CRT matches to NZ_CP028340 (Thauera aromatica K172 plasmid pKJK172, complete sequence) position: , mismatch: 6, identity: 0.818

cgacagaagatcgccgacaccgccctgcggctc--	CRISPR spacer
cgacataagatcgccgccaccgcc--gccgcttga	Protospacer
***** ********** *******  ** ***.

51. spacer 2.1|106975|33|NC_015951|PILER-CR,CRT matches to KC964605 (Uncultured bacterium plasmid pMLUA1, complete sequence) position: , mismatch: 6, identity: 0.818

cgacagaagatcgccgacaccgccctgcggctc--	CRISPR spacer
cgacataagatcgccgccaccgcc--gccgcttga	Protospacer
***** ********** *******  ** ***.

52. spacer 2.1|106975|33|NC_015951|PILER-CR,CRT matches to KC964606 (Uncultured bacterium plasmid pMLUA3, complete sequence) position: , mismatch: 6, identity: 0.818

cgacagaagatcgccgacaccgccctgcggctc--	CRISPR spacer
cgacataagatcgccgccaccgcc--gccgcttga	Protospacer
***** ********** *******  ** ***.

53. spacer 2.1|106975|33|NC_015951|PILER-CR,CRT matches to KC964607 (Uncultured bacterium plasmid pMLUA4, complete sequence) position: , mismatch: 6, identity: 0.818

cgacagaagatcgccgacaccgccctgcggctc--	CRISPR spacer
cgacataagatcgccgccaccgcc--gccgcttga	Protospacer
***** ********** *******  ** ***.

54. spacer 2.1|106975|33|NC_015951|PILER-CR,CRT matches to JQ004406 (Uncultured bacterium plasmid pHH128, complete sequence) position: , mismatch: 6, identity: 0.818

cgacagaagatcgccgacaccgccctgcggctc--	CRISPR spacer
cgacataagatcgccgccaccgcc--gccgcttga	Protospacer
***** ********** *******  ** ***.

55. spacer 2.1|106975|33|NC_015951|PILER-CR,CRT matches to JQ004407 (Uncultured bacterium plasmid pHH3408, complete sequence) position: , mismatch: 6, identity: 0.818

cgacagaagatcgccgacaccgccctgcggctc--	CRISPR spacer
cgacataagatcgccgccaccgcc--gccgcttga	Protospacer
***** ********** *******  ** ***.

56. spacer 2.1|106975|33|NC_015951|PILER-CR,CRT matches to JQ004408 (Uncultured bacterium plasmid pHH3414, complete sequence) position: , mismatch: 6, identity: 0.818

cgacagaagatcgccgacaccgccctgcggctc--	CRISPR spacer
cgacataagatcgccgccaccgcc--gccgcttga	Protospacer
***** ********** *******  ** ***.

57. spacer 2.1|106975|33|NC_015951|PILER-CR,CRT matches to JQ004409 (Uncultured bacterium plasmid pKS77, complete sequence) position: , mismatch: 6, identity: 0.818

cgacagaagatcgccgacaccgccctgcggctc--	CRISPR spacer
cgacataagatcgccgccaccgcc--gccgcttga	Protospacer
***** ********** *******  ** ***.

58. spacer 2.1|106975|33|NC_015951|PILER-CR,CRT matches to NZ_MN366356 (Bacterium plasmid pALTS27, complete sequence) position: , mismatch: 6, identity: 0.818

cgacagaagatcgccgacaccgccctgcggctc--	CRISPR spacer
cgacataagatcgccgccaccgcc--gccgcttga	Protospacer
***** ********** *******  ** ***.

59. spacer 2.1|106975|33|NC_015951|PILER-CR,CRT matches to NZ_MN366360 (Bacterium plasmid pALTS32, complete sequence) position: , mismatch: 6, identity: 0.818

cgacagaagatcgccgacaccgccctgcggctc--	CRISPR spacer
cgacataagatcgccgccaccgcc--gccgcttga	Protospacer
***** ********** *******  ** ***.

60. spacer 2.7|106976|32|NC_015951|CRISPRCasFinder matches to NZ_CP015006 (Aminobacter aminovorans strain KCTC 2477 plasmid pAA01, complete sequence) position: , mismatch: 6, identity: 0.812

gacagaagatcgccgacaccgccct--gcggctc	CRISPR spacer
aacagaagatcgccgaccgcgcccttggcagc--	Protospacer
.****************  ******  **.**

61. spacer 2.7|106976|32|NC_015951|CRISPRCasFinder matches to AM261282 (Uncultured bacterium IncP-1 plasmid pKJK5 complete sequence) position: , mismatch: 6, identity: 0.812

gacagaagatcgccgacaccgccctgcggctc--	CRISPR spacer
gacataagatcgccgccaccgcc--gccgcttga	Protospacer
**** ********** *******  ** ***.

62. spacer 2.7|106976|32|NC_015951|CRISPRCasFinder matches to NZ_CP028340 (Thauera aromatica K172 plasmid pKJK172, complete sequence) position: , mismatch: 6, identity: 0.812

gacagaagatcgccgacaccgccctgcggctc--	CRISPR spacer
gacataagatcgccgccaccgcc--gccgcttga	Protospacer
**** ********** *******  ** ***.

63. spacer 2.7|106976|32|NC_015951|CRISPRCasFinder matches to KC964605 (Uncultured bacterium plasmid pMLUA1, complete sequence) position: , mismatch: 6, identity: 0.812

gacagaagatcgccgacaccgccctgcggctc--	CRISPR spacer
gacataagatcgccgccaccgcc--gccgcttga	Protospacer
**** ********** *******  ** ***.

64. spacer 2.7|106976|32|NC_015951|CRISPRCasFinder matches to KC964606 (Uncultured bacterium plasmid pMLUA3, complete sequence) position: , mismatch: 6, identity: 0.812

gacagaagatcgccgacaccgccctgcggctc--	CRISPR spacer
gacataagatcgccgccaccgcc--gccgcttga	Protospacer
**** ********** *******  ** ***.

65. spacer 2.7|106976|32|NC_015951|CRISPRCasFinder matches to KC964607 (Uncultured bacterium plasmid pMLUA4, complete sequence) position: , mismatch: 6, identity: 0.812

gacagaagatcgccgacaccgccctgcggctc--	CRISPR spacer
gacataagatcgccgccaccgcc--gccgcttga	Protospacer
**** ********** *******  ** ***.

66. spacer 2.7|106976|32|NC_015951|CRISPRCasFinder matches to JQ004406 (Uncultured bacterium plasmid pHH128, complete sequence) position: , mismatch: 6, identity: 0.812

gacagaagatcgccgacaccgccctgcggctc--	CRISPR spacer
gacataagatcgccgccaccgcc--gccgcttga	Protospacer
**** ********** *******  ** ***.

67. spacer 2.7|106976|32|NC_015951|CRISPRCasFinder matches to JQ004407 (Uncultured bacterium plasmid pHH3408, complete sequence) position: , mismatch: 6, identity: 0.812

gacagaagatcgccgacaccgccctgcggctc--	CRISPR spacer
gacataagatcgccgccaccgcc--gccgcttga	Protospacer
**** ********** *******  ** ***.

68. spacer 2.7|106976|32|NC_015951|CRISPRCasFinder matches to JQ004408 (Uncultured bacterium plasmid pHH3414, complete sequence) position: , mismatch: 6, identity: 0.812

gacagaagatcgccgacaccgccctgcggctc--	CRISPR spacer
gacataagatcgccgccaccgcc--gccgcttga	Protospacer
**** ********** *******  ** ***.

69. spacer 2.7|106976|32|NC_015951|CRISPRCasFinder matches to JQ004409 (Uncultured bacterium plasmid pKS77, complete sequence) position: , mismatch: 6, identity: 0.812

gacagaagatcgccgacaccgccctgcggctc--	CRISPR spacer
gacataagatcgccgccaccgcc--gccgcttga	Protospacer
**** ********** *******  ** ***.

70. spacer 2.7|106976|32|NC_015951|CRISPRCasFinder matches to NZ_MN366356 (Bacterium plasmid pALTS27, complete sequence) position: , mismatch: 6, identity: 0.812

gacagaagatcgccgacaccgccctgcggctc--	CRISPR spacer
gacataagatcgccgccaccgcc--gccgcttga	Protospacer
**** ********** *******  ** ***.

71. spacer 2.7|106976|32|NC_015951|CRISPRCasFinder matches to NZ_MN366360 (Bacterium plasmid pALTS32, complete sequence) position: , mismatch: 6, identity: 0.812

gacagaagatcgccgacaccgccctgcggctc--	CRISPR spacer
gacataagatcgccgccaccgcc--gccgcttga	Protospacer
**** ********** *******  ** ***.

72. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP023408 (Streptomyces fungicidicus strain TXX3120 plasmid p1, complete sequence) position: , mismatch: 6, identity: 0.812

caccac-atcgacgaggcgacggtggcggcgag	CRISPR spacer
-gccacgatcgacgaggcgtcggcggcggccgg	Protospacer
 .**** ************ ***.****** .*

73. spacer 3.6|117293|29|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013052 (Sinorhizobium americanum CCGM7 plasmid A, complete sequence) position: , mismatch: 6, identity: 0.793

caaggggtgccgaccggcggcggcgacgt	CRISPR spacer
aaagtggtggcgaccggcggcggcgcttt	Protospacer
 *** **** *************** . *

74. spacer 3.6|117293|29|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013110 (Sinorhizobium americanum strain CFNEI 73 plasmid C, complete sequence) position: , mismatch: 6, identity: 0.793

caaggggtgccgaccggcggcggcgacgt	CRISPR spacer
aaagtggtggcgaccggcggcggcgcttt	Protospacer
 *** **** *************** . *

75. spacer 3.6|117293|29|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP024308 (Sinorhizobium fredii strain NXT3 plasmid pSfreNXT3a, complete sequence) position: , mismatch: 6, identity: 0.793

caaggggtgccgaccggcggcggcgacgt	CRISPR spacer
aaagtggtggcgaccggcggcggcgcttt	Protospacer
 *** **** *************** . *

76. spacer 3.6|117293|29|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP050081 (Rhizobium leguminosarum bv. trifolii strain 31B plasmid pRL31b5, complete sequence) position: , mismatch: 6, identity: 0.793

caaggggtgccgaccggcggcggcgacgt	CRISPR spacer
cctggtgtgctgaccggcggcggcgaaga	Protospacer
*  ** ****.*************** *

77. spacer 3.6|117293|29|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP049731 (Rhizobium leguminosarum strain A1 plasmid pRL12, complete sequence) position: , mismatch: 6, identity: 0.793

caaggggtgccgaccggcggcggcgacgt	CRISPR spacer
cctggtgtgctgaccggcggcggcgaaga	Protospacer
*  ** ****.*************** *

78. spacer 3.6|117293|29|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP008954 (Amycolatopsis japonica strain DSM 44213 plasmid pAmyja1, complete sequence) position: , mismatch: 6, identity: 0.793

caaggggtgccgaccggcggcggcgacgt	CRISPR spacer
gatggcgtgccgaccggtggcggcgaggc	Protospacer
 * ** ***********.******** *.

79. spacer 3.7|117351|32|NC_015951|CRISPRCasFinder,CRT matches to NZ_CP030772 (Streptomyces sp. YIM 121038 plasmid pSSP121038, complete sequence) position: , mismatch: 6, identity: 0.812

aatcgggacccccgcgaccgtgcgaccggccc	CRISPR spacer
tggggagaccccggcgaccgtgcgaccggccc	Protospacer
 .  *.****** *******************

80. spacer 3.8|117412|32|NC_015951|CRT matches to NC_017327 (Sinorhizobium meliloti SM11 plasmid pSmeSM11c, complete sequence) position: , mismatch: 6, identity: 0.812

ttcatcgcggcgaccaagaacgccgccgctca-	CRISPR spacer
ttcatcgcggcgcccaagaactcc-ccgtcgac	Protospacer
************ ******** ** ***.. *

81. spacer 3.8|117412|32|NC_015951|CRT matches to NZ_CP021801 (Sinorhizobium meliloti strain USDA1021 plasmid psymA, complete sequence) position: , mismatch: 6, identity: 0.812

ttcatcgcggcgaccaagaacgccgccgctca-	CRISPR spacer
ttcatcgcggcgcccaagaactcc-ccgtcgac	Protospacer
************ ******** ** ***.. *

82. spacer 3.8|117412|32|NC_015951|CRT matches to NZ_CP021819 (Sinorhizobium meliloti strain M162 plasmid psymA, complete sequence) position: , mismatch: 6, identity: 0.812

ttcatcgcggcgaccaagaacgccgccgctca-	CRISPR spacer
ttcatcgcggcgcccaagaactcc-ccgtcgac	Protospacer
************ ******** ** ***.. *

83. spacer 3.8|117412|32|NC_015951|CRT matches to NZ_CP021830 (Sinorhizobium meliloti strain HM006 plasmid psymA, complete sequence) position: , mismatch: 6, identity: 0.812

ttcatcgcggcgaccaagaacgccgccgctca-	CRISPR spacer
ttcatcgcggcgcccaagaactcc-ccgtcgac	Protospacer
************ ******** ** ***.. *

84. spacer 3.8|117412|32|NC_015951|CRT matches to NC_018683 (Sinorhizobium meliloti Rm41 plasmid pSYMA, complete sequence) position: , mismatch: 6, identity: 0.812

ttcatcgcggcgaccaagaacgccgccgctca-	CRISPR spacer
ttcatcgcggcgcccaagaactcc-ccgtcgac	Protospacer
************ ******** ** ***.. *

85. spacer 3.8|117412|32|NC_015951|CRT matches to NZ_CP021809 (Sinorhizobium meliloti strain Rm41 plasmid psymA, complete sequence) position: , mismatch: 6, identity: 0.812

ttcatcgcggcgaccaagaacgccgccgctca-	CRISPR spacer
ttcatcgcggcgcccaagaactcc-ccgtcgac	Protospacer
************ ******** ** ***.. *

86. spacer 3.8|117412|32|NC_015951|CRT matches to NZ_CP021217 (Sinorhizobium meliloti RU11/001 plasmid pSymA, complete sequence) position: , mismatch: 6, identity: 0.812

ttcatcgcggcgaccaagaacgccgccgctca-	CRISPR spacer
ttcatcgcggcgcccaagaactcc-ccgtcgac	Protospacer
************ ******** ** ***.. *

87. spacer 3.8|117412|32|NC_015951|CRT matches to NZ_CP026526 (Sinorhizobium meliloti strain AK21 plasmid pSymA, complete sequence) position: , mismatch: 6, identity: 0.812

ttcatcgcggcgaccaagaacgccgccgctca-	CRISPR spacer
ttcatcgcggcgcccaagaactcc-ccgtcgac	Protospacer
************ ******** ** ***.. *

88. spacer 3.8|117412|32|NC_015951|CRT matches to NZ_CP019483 (Sinorhizobium meliloti strain B401 plasmid pSymA, complete sequence) position: , mismatch: 6, identity: 0.812

ttcatcgcggcgaccaagaacgccgccgctca-	CRISPR spacer
ttcatcgcggcgcccaagaactcc-ccgtcgac	Protospacer
************ ******** ** ***.. *

89. spacer 3.8|117412|32|NC_015951|CRT matches to NZ_CP019486 (Sinorhizobium meliloti strain B399 plasmid pSymA, complete sequence) position: , mismatch: 6, identity: 0.812

ttcatcgcggcgaccaagaacgccgccgctca-	CRISPR spacer
ttcatcgcggcgcccaagaactcc-ccgtcgac	Protospacer
************ ******** ** ***.. *

90. spacer 1.1|104635|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 7, identity: 0.781

taccgcgccgtcaccggggccaccccgaactg	CRISPR spacer
gcccacgccgtcaccgcggccaccccgggcag	Protospacer
  **.*********** **********..* *

91. spacer 1.1|104635|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 7, identity: 0.781

taccgcgccgtcaccggggccaccccgaactg	CRISPR spacer
gcccacgccgtcaccgcggccaccccgggcag	Protospacer
  **.*********** **********..* *

92. spacer 1.1|104635|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP034153 (Rhodococcus sp. NJ-530 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.781

taccgcgccgtcaccggggccaccccgaactg	CRISPR spacer
ctcggcgacgtcaccgggaccaccccgaccgg	Protospacer
. * *** **********.********* * *

93. spacer 1.2|104696|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to KT001914 (Caulobacter phage Seuss, complete genome) position: , mismatch: 7, identity: 0.781

cacatcgcgctcgcgccccgcacgagcagcac	CRISPR spacer
taccaggcgctcgcgctccgcacgaacagccc	Protospacer
.**   **********.********.**** *

94. spacer 1.4|104818|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP032685 (Rhizobium sp. CCGE531 plasmid pRCCGE531d, complete sequence) position: , mismatch: 7, identity: 0.781

tccgcaggtcggccccgtggtcaacggtcaga-	CRISPR spacer
gccgcaggtcggcgtcgtggtcaa-gatcggcg	Protospacer
 ************ .********* *.**.*

95. spacer 1.4|104818|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP032690 (Rhizobium sp. CCGE532 plasmid pRCCGE532d, complete sequence) position: , mismatch: 7, identity: 0.781

tccgcaggtcggccccgtggtcaacggtcaga-	CRISPR spacer
gccgcaggtcggcgtcgtggtcaa-gatcggcg	Protospacer
 ************ .********* *.**.*

96. spacer 2.1|106975|33|NC_015951|PILER-CR,CRT matches to NZ_CP015006 (Aminobacter aminovorans strain KCTC 2477 plasmid pAA01, complete sequence) position: , mismatch: 7, identity: 0.788

cgacagaagatcgccgacaccgccct--gcggctc	CRISPR spacer
gaacagaagatcgccgaccgcgcccttggcagc--	Protospacer
 .****************  ******  **.**

97. spacer 2.4|107159|32|NC_015951|PILER-CR,CRT matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 7, identity: 0.781

cgggaccaggtccgctgggc--gaggtccccggc	CRISPR spacer
cgggaccagatccgctgtgcgagaggccttcg--	Protospacer
*********.******* **  ****.*..**

98. spacer 2.7|106976|32|NC_015951|CRISPRCasFinder matches to NZ_CP010408 (Streptomyces vietnamensis strain GIMV4.0001 plasmid pSVL1, complete sequence) position: , mismatch: 7, identity: 0.781

gacagaagatcgccgacaccgccctgcggctc	CRISPR spacer
ggcagcagatcgccgacgccgccctggagtac	Protospacer
*.*** ***********.******** .*. *

99. spacer 2.7|106976|32|NC_015951|CRISPRCasFinder matches to NC_015178 (Acidiphilium multivorum AIU301 plasmid pACMV1, complete sequence) position: , mismatch: 7, identity: 0.781

gacagaagatcgccgacaccgccctgcggctc	CRISPR spacer
gccagcgcctcgccgagaacgccctgcggctc	Protospacer
* *** .  ******* * *************

100. spacer 2.10|107160|31|NC_015951|CRISPRCasFinder matches to NC_002575 (Agrobacterium rhizogenes plasmid pRi1724 DNA, complete sequence) position: , mismatch: 7, identity: 0.774

gggaccaggtccgctgggcgaggtccccggc	CRISPR spacer
gctgctcggtccgcttggcgaggtcctcggc	Protospacer
*  .*. ******** **********.****

101. spacer 2.10|107160|31|NC_015951|CRISPRCasFinder matches to NZ_KY000038 (Agrobacterium rhizogenes strain 1724 plasmid pRi_1724, complete sequence) position: , mismatch: 7, identity: 0.774

gggaccaggtccgctgggcgaggtccccggc	CRISPR spacer
gctgctcggtccgcttggcgaggtcctcggc	Protospacer
*  .*. ******** **********.****

102. spacer 2.12|107282|31|NC_015951|CRISPRCasFinder matches to NZ_CP023707 (Edwardsiella tarda strain KC-Pc-HB1 plasmid pEh-Pc1, complete sequence) position: , mismatch: 7, identity: 0.774

atcagcaagatcctggagacgcccgacgggg	CRISPR spacer
acccgcatgatcctggagacgcccgatcgtt	Protospacer
*.* *** ******************. *

103. spacer 2.12|107282|31|NC_015951|CRISPRCasFinder matches to CP007644 (Rhizobium etli bv. phaseoli str. IE4803 plasmid pRetIE4803c, complete sequence) position: , mismatch: 7, identity: 0.774

atcagcaagatcctggagacgcccgacgggg	CRISPR spacer
atcctgaagaccctggagacgctcgacggtt	Protospacer
***   ****.***********.******

104. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP050104 (Rhizobium leguminosarum bv. trifolii strain 4B plasmid pRL4b2, complete sequence) position: , mismatch: 7, identity: 0.781

caccacatcgacgaggcgacggtggcggcgag	CRISPR spacer
cgcctcatcgtcgaggcgacggtggcggacga	Protospacer
*.** ***** *****************  ..

105. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013110 (Sinorhizobium americanum strain CFNEI 73 plasmid C, complete sequence) position: , mismatch: 7, identity: 0.781

caccacatcgacgaggcgacggtggcggcgag	CRISPR spacer
gccggcatcgacgaggcgacgctgacggcgat	Protospacer
  * .**************** **.******

106. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP025507 (Rhizobium leguminosarum bv. viciae strain UPM791 plasmid pRlvA, complete sequence) position: , mismatch: 7, identity: 0.781

caccacatcgacgaggcgacggtggcggcgag	CRISPR spacer
cgcctcatcgtcgaggcgacggtggcggacga	Protospacer
*.** ***** *****************  ..

107. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP050109 (Rhizobium leguminosarum bv. trifolii strain 3B plasmid pRL3b2, complete sequence) position: , mismatch: 7, identity: 0.781

caccacatcgacgaggcgacggtggcggcgag	CRISPR spacer
cgcctcatcgtcgaggcgacggtggcggacga	Protospacer
*.** ***** *****************  ..

108. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP030761 (Rhizobium leguminosarum strain ATCC 14479 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.781

caccacatcgacgaggcgacggtggcggcgag	CRISPR spacer
cgcctcatcgtcgaggcgacggtggcggacga	Protospacer
*.** ***** *****************  ..

109. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP022666 (Rhizobium leguminosarum bv. viciae strain BIHB 1217 plasmid pPR1, complete sequence) position: , mismatch: 7, identity: 0.781

caccacatcgacgaggcgacggtggcggcgag	CRISPR spacer
cgcctcatcgtcgaggcgacggtggcggacga	Protospacer
*.** ***** *****************  ..

110. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP050086 (Rhizobium leguminosarum bv. trifolii strain 23B plasmid pRL23b7, complete sequence) position: , mismatch: 7, identity: 0.781

caccacatcgacgaggcgacggtggcggcgag	CRISPR spacer
cgcctcatcgtcgaggcgacggtggcggacga	Protospacer
*.** ***** *****************  ..

111. spacer 3.4|117171|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP020327 (Mycobacterium avium subsp. hominissuis strain JP-H-1 plasmid p1-JPH1) position: , mismatch: 7, identity: 0.781

ggtgccggtcgcgtggttgatctggcggatgg	CRISPR spacer
gctgccggtggcgtggttggtctgggcgtcgg	Protospacer
* ******* *********.*****  * .**

112. spacer 3.5|117232|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP039640 (Azospirillum sp. TSH100 plasmid p1, complete sequence) position: , mismatch: 7, identity: 0.781

ccgcactggaagaccagcgcctggaccgcctc	CRISPR spacer
accggctggaagacccgcgcctggcccgcccc	Protospacer
 *  .********** ******** *****.*

113. spacer 3.5|117232|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NC_016972 (Streptomyces hygroscopicus subsp. jinggangensis 5008 plasmid pSHJG2, complete sequence) position: , mismatch: 7, identity: 0.781

ccgcactggaagaccagcgcctggaccgcctc	CRISPR spacer
cggcactggaagaccagcgcaaggacgttcgc	Protospacer
* ******************  ****  .* *

114. spacer 3.6|117293|29|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 7, identity: 0.759

caaggggtgccgaccggcggcggcgacgt	CRISPR spacer
ccgggggtgccgatcggcggcggcccctg	Protospacer
* .**********.**********  *

115. spacer 3.6|117293|29|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP017943 (Phyllobacterium zundukense strain Tri-48 plasmid unnamed2, complete sequence) position: , mismatch: 7, identity: 0.759

caaggggtgccgaccggcggcggcgacgt	CRISPR spacer
ttccggctgccgaccggccgcggcgacga	Protospacer
.   ** *********** *********

116. spacer 3.6|117293|29|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP029453 (Sinorhizobium fredii CCBAU 25509 plasmid pSF25509a, complete sequence) position: , mismatch: 7, identity: 0.759

caaggggtgccgaccggcggcggcgacgt	CRISPR spacer
tcgtgattgccgaccggcggcggcggcgt	Protospacer
. . *. ******************.***

117. spacer 3.6|117293|29|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP007256 (Rhodococcus erythropolis R138 plasmid pCRE138, complete sequence) position: , mismatch: 7, identity: 0.759

caaggggtgccgaccggcggcggcgacgt	CRISPR spacer
gcgagggtgccgaccagcggcggcaacgg	Protospacer
  ..***********.********.***

118. spacer 3.6|117293|29|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP023069 (Ensifer sojae CCBAU 05684 plasmid pSJ05684a, complete sequence) position: , mismatch: 7, identity: 0.759

caaggggtgccgaccggcggcggcgacgt	CRISPR spacer
tcgtgattgccgaccggcggcggcggcgt	Protospacer
. . *. ******************.***

119. spacer 3.6|117293|29|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP023065 (Sinorhizobium sp. CCBAU 05631 plasmid pSS05631a, complete sequence) position: , mismatch: 7, identity: 0.759

caaggggtgccgaccggcggcggcgacgt	CRISPR spacer
agctgattgccgaccggcggcggcggcgt	Protospacer
 .  *. ******************.***

120. spacer 3.6|117293|29|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP029233 (Sinorhizobium fredii CCBAU 45436 plasmid pSF45436a, complete sequence) position: , mismatch: 7, identity: 0.759

caaggggtgccgaccggcggcggcgacgt	CRISPR spacer
tcgtgattgccgaccggcggcggcggcgt	Protospacer
. . *. ******************.***

121. spacer 3.6|117293|29|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NC_017958 (Tistrella mobilis KA081020-065 plasmid pTM3, complete sequence) position: , mismatch: 7, identity: 0.759

caaggggtgccgaccggcggcggcgacgt	CRISPR spacer
gtgcgggtgctgaccggcggcggcgccgc	Protospacer
  . ******.************** **.

122. spacer 3.6|117293|29|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP023072 (Sinorhizobium fredii CCBAU 83666 plasmid pSF83666a, complete sequence) position: , mismatch: 7, identity: 0.759

caaggggtgccgaccggcggcggcgacgt	CRISPR spacer
agctgattgccgaccggcggcggcggcgt	Protospacer
 .  *. ******************.***

123. spacer 3.6|117293|29|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NC_000914 (Sinorhizobium fredii NGR234 plasmid pNGR234a, complete sequence) position: , mismatch: 7, identity: 0.759

caaggggtgccgaccggcggcggcgacgt	CRISPR spacer
tcgtgattgccgaccggcggcggcggcgt	Protospacer
. . *. ******************.***

124. spacer 3.6|117293|29|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP009803 (Streptomyces sp. FR-008 plasmid pSSFR1, complete sequence) position: , mismatch: 7, identity: 0.759

caaggggtgccgaccggcggcggcgacgt	CRISPR spacer
ggtgcggggccgaccggcggcggcgagga	Protospacer
 . * ** ****************** *

125. spacer 3.8|117412|32|NC_015951|CRT matches to NZ_CP032695 (Rhizobium jaguaris strain CCGE525 plasmid pRCCGE525c, complete sequence) position: , mismatch: 7, identity: 0.781

ttcatcgcggcgaccaagaacgccgc-cgctca	CRISPR spacer
ctgatcccggagaccaagaacgccgcgcggcc-	Protospacer
.* *** *** *************** ** .*

126. spacer 3.9|117473|31|NC_015951|CRT matches to NZ_CP032695 (Rhizobium jaguaris strain CCGE525 plasmid pRCCGE525c, complete sequence) position: , mismatch: 7, identity: 0.774

cgcgctcggtgtacttggggccctcgccggg	CRISPR spacer
tgcgctcggtgtactgggggcactaggagtg	Protospacer
.************** ***** ** *  * *

127. spacer 1.1|104635|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP032348 (Azospirillum brasilense strain MTCC4039 plasmid p4, complete sequence) position: , mismatch: 8, identity: 0.75

taccgcgccgtcaccggggccaccccgaactg	CRISPR spacer
ccacgcgccgtgaccggggccacgccgggctc	Protospacer
.  ******** *********** ***..**

128. spacer 1.2|104696|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to CP000876 (Herpetosiphon aurantiacus DSM 785 plasmid pHAU01, complete sequence) position: , mismatch: 8, identity: 0.75

cacatcgcgctcgcgccccgcacgagcagcac	CRISPR spacer
cagcacgcgctcgcgcacggcacgagcatccg	Protospacer
**   *********** * ********* *

129. spacer 2.1|106975|33|NC_015951|PILER-CR,CRT matches to NZ_CP010408 (Streptomyces vietnamensis strain GIMV4.0001 plasmid pSVL1, complete sequence) position: , mismatch: 8, identity: 0.758

cgacagaagatcgccgacaccgccctgcggctc	CRISPR spacer
tggcagcagatcgccgacgccgccctggagtac	Protospacer
.*.*** ***********.******** .*. *

130. spacer 2.4|107159|32|NC_015951|PILER-CR,CRT matches to NC_002575 (Agrobacterium rhizogenes plasmid pRi1724 DNA, complete sequence) position: , mismatch: 8, identity: 0.75

cgggaccaggtccgctgggcgaggtccccggc	CRISPR spacer
tgctgctcggtccgcttggcgaggtcctcggc	Protospacer
.*  .*. ******** **********.****

131. spacer 2.4|107159|32|NC_015951|PILER-CR,CRT matches to NZ_KY000038 (Agrobacterium rhizogenes strain 1724 plasmid pRi_1724, complete sequence) position: , mismatch: 8, identity: 0.75

cgggaccaggtccgctgggcgaggtccccggc	CRISPR spacer
tgctgctcggtccgcttggcgaggtcctcggc	Protospacer
.*  .*. ******** **********.****

132. spacer 2.6|107281|32|NC_015951|PILER-CR,CRT matches to CP007644 (Rhizobium etli bv. phaseoli str. IE4803 plasmid pRetIE4803c, complete sequence) position: , mismatch: 8, identity: 0.75

catcagcaagatcctggagacgcccgacgggg	CRISPR spacer
gatcctgaagaccctggagacgctcgacggtt	Protospacer
 ***   ****.***********.******

133. spacer 2.7|106976|32|NC_015951|CRISPRCasFinder matches to NZ_CP039640 (Azospirillum sp. TSH100 plasmid p1, complete sequence) position: , mismatch: 8, identity: 0.75

gacagaagatcgccgacaccgccctgcggctc	CRISPR spacer
cgcgcagcatcgccgacaccgcccaccggctc	Protospacer
 .*. *. ****************  ******

134. spacer 2.9|107099|31|NC_015951|CRISPRCasFinder matches to NZ_CP029831 (Azospirillum ramasamyi strain M2T2B2 plasmid unnamed7, complete sequence) position: , mismatch: 8, identity: 0.742

tgtcccatccgcacatcgtcaccgtgcacga	CRISPR spacer
agtcccggccgcacatcgtcaccgaccagac	Protospacer
 *****. ****************  ** .

135. spacer 2.12|107282|31|NC_015951|CRISPRCasFinder matches to NZ_CP048281 (Rhizobium leguminosarum bv. viciae 248 plasmid pRle248e, complete sequence) position: , mismatch: 8, identity: 0.742

atcagcaagatcctggagacgcccgacgggg	CRISPR spacer
gtcctgaagaccctggagacgctcgacggtc	Protospacer
.**   ****.***********.******

136. spacer 3.1|116988|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP030074 (Streptomyces sp. ZFG47 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.75

tcagcaggatcgtcacgagcccggtccatgcc	CRISPR spacer
tcagcaggttcgtcacgcgcccggtctccagg	Protospacer
******** ******** ********. ..

137. spacer 3.2|117049|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 8, identity: 0.75

gagatggccaagggcgggcagccccaggcgat	CRISPR spacer
gagatggccgaggccgggcagccgcccggggg	Protospacer
*********.*** ********* *  * *.

138. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP029777 (Deinococcus actinosclerus strain Deinococcus actinosclerus SJTR plasmid unnamed3, complete sequence) position: , mismatch: 8, identity: 0.75

caccacatcgacgaggcgacggtggcggcgag	CRISPR spacer
accctgatcgacgaggcggcggtggcggccgc	Protospacer
  **  ************.********** .

139. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP032828 (Sphingomonas sp. YZ-8 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.75

caccacatcgacgaggcgacggtggcggcgag	CRISPR spacer
ggcggcctcgtcgcggcgacggtggcggcgat	Protospacer
 .* .* *** ** *****************

140. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 8, identity: 0.75

caccacatcgacgaggcgacggtggcggcgag	CRISPR spacer
gacctcttcgacgaggcgacggtggtgcgcat	Protospacer
 *** * ******************.*   *

141. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 8, identity: 0.75

caccacatcgacgaggcgacggtggcggcgag	CRISPR spacer
gacctcttcgacgaggcgacggtggtgcgcat	Protospacer
 *** * ******************.*   *

142. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP050081 (Rhizobium leguminosarum bv. trifolii strain 31B plasmid pRL31b5, complete sequence) position: , mismatch: 8, identity: 0.75

caccacatcgacgaggcgacggtggcggcgag	CRISPR spacer
cgcctgatcgtcgaggcgaaggtggcggccgc	Protospacer
*.**  **** ******** ********* .

143. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP015420 (Rhodovulum sulfidophilum DSM 1374 plasmid unnamed2, complete sequence) position: , mismatch: 8, identity: 0.75

caccacatcgacgaggcgacggtggcggcgag	CRISPR spacer
cagatcatcggcgaggcggcggtggcggggct	Protospacer
**   *****.*******.********* *

144. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP040819 (Paraoceanicella profunda strain D4M1 plasmid pD4M1A, complete sequence) position: , mismatch: 8, identity: 0.75

caccacatcgacgaggcgacggtggcggcgag	CRISPR spacer
ccctacatcgccgaggcgccggtggcgctgga	Protospacer
* *.****** ******* ******** .*..

145. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP040819 (Paraoceanicella profunda strain D4M1 plasmid pD4M1A, complete sequence) position: , mismatch: 8, identity: 0.75

caccacatcgacgaggcgacggtggcggcgag	CRISPR spacer
ccctacatcgccgaggcgccggtggcgctgga	Protospacer
* *.****** ******* ******** .*..

146. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP015882 (Ensifer adhaerens strain Casida A plasmid pCasidaAB, complete sequence) position: , mismatch: 8, identity: 0.75

caccacatc----gacgaggcgacggtggcggcgag	CRISPR spacer
----gcgtcgtctgacgaggcgacgatggcggccag	Protospacer
    .*.**    ************.******* **

147. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP054022 (Rhizobium sp. JKLM12A2 plasmid pPR12A201, complete sequence) position: , mismatch: 8, identity: 0.75

caccacatcgacgaggcgacggtggcggcgag	CRISPR spacer
aacggcgtcgacgaggcgacgatggaggcggt	Protospacer
 ** .*.**************.*** ****.

148. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP054026 (Rhizobium sp. JKLM12A2 plasmid pPR12A205, complete sequence) position: , mismatch: 8, identity: 0.75

caccacatcgacgaggcgacggtggcggcgag	CRISPR spacer
ccgccgatcgacgaggcgacgatgacggccac	Protospacer
*  *  ***************.**.**** *

149. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP030264 (Ensifer adhaerens strain Corn53 plasmid AB, complete sequence) position: , mismatch: 8, identity: 0.75

caccacatc----gacgaggcgacggtggcggcgag	CRISPR spacer
----gcgtcgtctgacgaggcgacgatggcggccag	Protospacer
    .*.**    ************.******* **

150. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP014801 (Rhodovulum sulfidophilum plasmid Plasmid1 DNA, complete genome, strain: DSM 2351) position: , mismatch: 8, identity: 0.75

caccacatcgacgaggcgacggtggcggcgag	CRISPR spacer
cagatcatcggcgaggcggcggtggcggggct	Protospacer
**   *****.*******.********* *

151. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP054036 (Rhizobium sp. JKLM13E plasmid pPR13E05, complete sequence) position: , mismatch: 8, identity: 0.75

caccacatcgacgaggcgacggtggcggcgag	CRISPR spacer
ccgccgatcgacgaggcgacgatgacggccac	Protospacer
*  *  ***************.**.**** *

152. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NC_020548 (Azoarcus sp. KH32C plasmid pAZKH, complete sequence) position: , mismatch: 8, identity: 0.75

-caccacatcgacgaggcgacggtggcggcgag	CRISPR spacer
tcgctgc-tcgacgaggcgactgcggcggcgga	Protospacer
 *.*..* ************* *.*******..

153. spacer 3.4|117171|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP054613 (Paenibacillus cellulosilyticus strain KACC 14175 plasmid unnamed4, complete sequence) position: , mismatch: 8, identity: 0.75

ggtgccggtcgcgtggttgatctggcggatgg	CRISPR spacer
tatctcggtcgcgtcgttgagctggcggagag	Protospacer
 .* .********* ***** ******** .*

154. spacer 3.4|117171|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to MH015258 (Ruegeria phage vB_RpoS-V16, complete genome) position: , mismatch: 8, identity: 0.75

ggtgccggtcgcgtggttgatctggcggatgg	CRISPR spacer
cggatcggtcgcgcggttgatctggaggtcgg	Protospacer
 * ..********.*********** ** .**

155. spacer 3.4|117171|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to MH015249 (Ruegeria phage vB_RpoS-V7, complete genome) position: , mismatch: 8, identity: 0.75

ggtgccggtcgcgtggttgatctggcggatgg	CRISPR spacer
cggatcggtcgcgcggttgatctggaggtcgg	Protospacer
 * ..********.*********** ** .**

156. spacer 3.4|117171|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to KM581061 (Ruegeria phage DSS3-P1, complete genome) position: , mismatch: 8, identity: 0.75

ggtgccggtcgcgtggttgatctggcggatgg	CRISPR spacer
cggatcggtcgcgcggttgatctggaggtcgg	Protospacer
 * ..********.*********** ** .**

157. spacer 3.4|117171|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to HQ632855 (Silicibacter phage DSS3-P1, *** SEQUENCING IN PROGRESS ***, 6 unordered pieces) position: , mismatch: 8, identity: 0.75

ggtgccggtcgcgtggttgatctggcggatgg	CRISPR spacer
cggatcggtcgcgcggttgatctggaggtcgg	Protospacer
 * ..********.*********** ** .**

158. spacer 3.4|117171|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to MH015254 (Ruegeria phage vB_RpoS-V11, complete genome) position: , mismatch: 8, identity: 0.75

ggtgccggtcgcgtggttgatctggcggatgg	CRISPR spacer
cggatcggtcgcgcggttgatctggaggtcgg	Protospacer
 * ..********.*********** ** .**

159. spacer 3.4|117171|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to MH015252 (Ruegeria phage vB_RpoS-V18, complete genome) position: , mismatch: 8, identity: 0.75

ggtgccggtcgcgtggttgatctggcggatgg	CRISPR spacer
cggatcggtcgcgcggttgatctggaggtcgg	Protospacer
 * ..********.*********** ** .**

160. spacer 3.5|117232|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to LC473083 (Cutibacterium acnes TP-CU389 plasmid pTZC1 DNA, complete sequence) position: , mismatch: 8, identity: 0.75

ccgcac-tggaagaccagcgcctggaccgcctc	CRISPR spacer
-tgcgcgtggaagaccagcgccacgaccgcgat	Protospacer
 .**.* ***************  ******  .

161. spacer 3.6|117293|29|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NC_012586 (Sinorhizobium fredii NGR234 plasmid pNGR234b, complete sequence) position: , mismatch: 8, identity: 0.724

caaggggtgccgaccggcggcggcgacgt	CRISPR spacer
attctggtgacgaccggcggcggcggcga	Protospacer
     **** ***************.**

162. spacer 3.6|117293|29|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP007130 (Gemmatirosa kalamazoonesis strain KBS708 plasmid 2, complete sequence) position: , mismatch: 8, identity: 0.724

caaggggtgccgaccggcggcggcgacgt	CRISPR spacer
tggaaggtgccgaccgccggcggcgaggc	Protospacer
.....*********** ********* *.

163. spacer 3.6|117293|29|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NC_010510 (Methylobacterium radiotolerans JCM 2831 plasmid pMRAD01, complete sequence) position: , mismatch: 8, identity: 0.724

caaggggtgccgaccggcggcggcgacgt	CRISPR spacer
gcgctggtgccggccggcggcggcgatct	Protospacer
  .  *******.*************. *

164. spacer 3.6|117293|29|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NC_011879 (Pseudarthrobacter chlorophenolicus A6 plasmid pACHL01, complete sequence) position: , mismatch: 8, identity: 0.724

caaggggtgccgaccggcggcggcgacgt	CRISPR spacer
gtccaggtgccggccggcggcggccacgg	Protospacer
    .*******.*********** ***

165. spacer 3.6|117293|29|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP032685 (Rhizobium sp. CCGE531 plasmid pRCCGE531d, complete sequence) position: , mismatch: 8, identity: 0.724

caaggggtgccgaccggcggcggcgacgt	CRISPR spacer
atcctggtgacgaccggcggcggcggcga	Protospacer
     **** ***************.**

166. spacer 3.6|117293|29|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP032690 (Rhizobium sp. CCGE532 plasmid pRCCGE532d, complete sequence) position: , mismatch: 8, identity: 0.724

caaggggtgccgaccggcggcggcgacgt	CRISPR spacer
atcctggtgacgaccggcggcggcggcga	Protospacer
     **** ***************.**

167. spacer 3.6|117293|29|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LR134463 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 21, complete sequence) position: , mismatch: 8, identity: 0.724

caaggggtgccgaccggcggcggcgacgt	CRISPR spacer
ggtgtggcgccgaccggcggcggcgatcg	Protospacer
 . * **.******************.

168. spacer 3.6|117293|29|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013503 (Rhizobium esperanzae strain N561 plasmid pRspN561c, complete sequence) position: , mismatch: 8, identity: 0.724

caaggggtgccgaccggcggcggcgacgt	CRISPR spacer
gtcacggcgccgaccggcggcggctacgg	Protospacer
   . **.**************** ***

169. spacer 3.6|117293|29|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013509 (Rhizobium sp. N1341 plasmid pRspN1341d, complete sequence) position: , mismatch: 8, identity: 0.724

caaggggtgccgaccggcggcggcgacgt	CRISPR spacer
gtcacggcgccgaccggcggcggctacgg	Protospacer
   . **.**************** ***

170. spacer 3.6|117293|29|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013520 (Rhizobium sp. N113 plasmid pRspN113c, complete sequence) position: , mismatch: 8, identity: 0.724

caaggggtgccgaccggcggcggcgacgt	CRISPR spacer
gtcacggcgccgaccggcggcggctacgg	Protospacer
   . **.**************** ***

171. spacer 3.6|117293|29|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013493 (Rhizobium sp. N6212 plasmid pRspN6212c, complete sequence) position: , mismatch: 8, identity: 0.724

caaggggtgccgaccggcggcggcgacgt	CRISPR spacer
gtcacggcgccgaccggcggcggctacgg	Protospacer
   . **.**************** ***

172. spacer 3.6|117293|29|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NC_018853 (Streptomyce phage TG1, complete genome) position: , mismatch: 8, identity: 0.724

caaggggtgccgaccggcggcggcgacgt	CRISPR spacer
ggcagggtgccgaccggcagcggcggcaa	Protospacer
 . .**************.******.*.

173. spacer 3.6|117293|29|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to JX182372 (Streptomyces virus TG1, complete genome) position: , mismatch: 8, identity: 0.724

caaggggtgccgaccggcggcggcgacgt	CRISPR spacer
ggcagggtgccgaccggcagcggcggcaa	Protospacer
 . .**************.******.*.

174. spacer 3.8|117412|32|NC_015951|CRT matches to NZ_AP014579 (Burkholderia sp. RPE67 plasmid p1, complete sequence) position: , mismatch: 8, identity: 0.75

ttcatcgcggcgaccaagaacgccgccgctca	CRISPR spacer
gggttcgccgcgaccaagtacgccgccgcgcg	Protospacer
    **** ********* ********** *.

175. spacer 3.8|117412|32|NC_015951|CRT matches to NC_016626 (Burkholderia sp. YI23 plasmid byi_1p, complete sequence) position: , mismatch: 8, identity: 0.75

ttcatcgcggcgaccaagaacgccgccgctca	CRISPR spacer
gggttcgccgcgaccaagtacgccgccgcgcg	Protospacer
    **** ********* ********** *.

176. spacer 3.8|117412|32|NC_015951|CRT matches to NZ_CP018472 (Xanthomonas perforans strain LH3 plasmid pLH3.1, complete sequence) position: , mismatch: 8, identity: 0.75

ttcatcgcggcgaccaagaacgccgccgctca	CRISPR spacer
aacacctgggcgaccaagaacgccgacggtcc	Protospacer
  **.*  ***************** ** **

177. spacer 3.8|117412|32|NC_015951|CRT matches to NZ_CP023286 (Xanthomonas citri pv. citri strain 03-1638-1-1 plasmid pCuR, complete sequence) position: , mismatch: 8, identity: 0.75

ttcatcgcggcgaccaagaacgccgccgctca	CRISPR spacer
aacacctgggcgaccaagaacgccgacggtcc	Protospacer
  **.*  ***************** ** **

178. spacer 3.8|117412|32|NC_015951|CRT matches to NZ_CP018859 (Xanthomonas citri pv. citri strain LH201 plasmid pLH201.1, complete sequence) position: , mismatch: 8, identity: 0.75

ttcatcgcggcgaccaagaacgccgccgctca	CRISPR spacer
aacacctgggcgaccaagaacgccgacggtcc	Protospacer
  **.*  ***************** ** **

179. spacer 3.8|117412|32|NC_015951|CRT matches to NZ_CP018851 (Xanthomonas citri pv. citri strain LJ207-7 plasmid pLJ207-7.1, complete sequence) position: , mismatch: 8, identity: 0.75

ttcatcgcggcgaccaagaacgccgccgctca	CRISPR spacer
aacacctgggcgaccaagaacgccgacggtcc	Protospacer
  **.*  ***************** ** **

180. spacer 3.8|117412|32|NC_015951|CRT matches to NZ_CP018848 (Xanthomonas citri pv. citri strain LL074-4 plasmid pLL074-4.1, complete sequence) position: , mismatch: 8, identity: 0.75

ttcatcgcggcgaccaagaacgccgccgctca	CRISPR spacer
aacacctgggcgaccaagaacgccgacggtcc	Protospacer
  **.*  ***************** ** **

181. spacer 3.8|117412|32|NC_015951|CRT matches to NZ_CP018855 (Xanthomonas citri pv. citri strain LH276 plasmid pLH276.1, complete sequence) position: , mismatch: 8, identity: 0.75

ttcatcgcggcgaccaagaacgccgccgctca	CRISPR spacer
aacacctgggcgaccaagaacgccgacggtcc	Protospacer
  **.*  ***************** ** **

182. spacer 3.8|117412|32|NC_015951|CRT matches to NZ_CP016287 (Rhizobium leguminosarum strain Vaf10 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.75

ttcatcgcggcgaccaagaacgccgccgctca	CRISPR spacer
ctcgacggggcgaccgagaacgccgccggccg	Protospacer
.**. ** *******.************ .*.

183. spacer 3.8|117412|32|NC_015951|CRT matches to NZ_CP018729 (Xanthomonas gardneri strain JS749-3 plasmid pJS749-3.1, complete sequence) position: , mismatch: 8, identity: 0.75

ttcatcgcggcgaccaagaacgccgccgctca	CRISPR spacer
aacacctgggcgaccaagaacgccgacggtcc	Protospacer
  **.*  ***************** ** **

184. spacer 3.8|117412|32|NC_015951|CRT matches to NZ_CP018732 (Xanthomonas gardneri strain ICMP 7383 plasmid pICMP7383.1, complete sequence) position: , mismatch: 8, identity: 0.75

ttcatcgcggcgaccaagaacgccgccgctca	CRISPR spacer
aacacctgggcgaccaagaacgccgacggtcc	Protospacer
  **.*  ***************** ** **

185. spacer 1.2|104696|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP035514 (Haematobacter massiliensis strain OT1 plasmid pOT1-4, complete sequence) position: , mismatch: 9, identity: 0.719

cacatcgcgctcgcgccccgcacgagcagcac	CRISPR spacer
tggccggcgctcgcgccccgcgccagcagcag	Protospacer
..  . ***************.* *******

186. spacer 1.2|104696|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP018784 (Curtobacterium pusillum strain AA3 plasmid pCPAA3, complete sequence) position: , mismatch: 9, identity: 0.719

cacatcgcgctcgcgccccgcacgagcagcac	CRISPR spacer
accatcacgctcgcgcccggcacgacccgtgg	Protospacer
  ****.*********** ****** * *..

187. spacer 1.2|104696|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP012748 (Paraburkholderia caribensis MBA4 plasmid unnamed, complete sequence) position: , mismatch: 9, identity: 0.719

cacatcgcgctcgcgccccgcacgagcagcac	CRISPR spacer
tcgatcccgctcgcgccccggacgagtttcgc	Protospacer
.  *** ************* *****.  *.*

188. spacer 1.2|104696|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP012399 (Chelatococcus sp. CO-6 plasmid pCO-6, complete sequence) position: , mismatch: 9, identity: 0.719

cacatcgcgctcgcgccccgcacgagcagcac	CRISPR spacer
gtcatcgcgctcgcgcgccggacgatgggcga	Protospacer
  ************** *** ****  .**.

189. spacer 2.1|106975|33|NC_015951|PILER-CR,CRT matches to NZ_CP039640 (Azospirillum sp. TSH100 plasmid p1, complete sequence) position: , mismatch: 9, identity: 0.727

cgacagaagatcgccgacaccgccctgcggctc	CRISPR spacer
tcgcgcagcatcgccgacaccgcccaccggctc	Protospacer
. .*. *. ****************  ******

190. spacer 2.3|107098|32|NC_015951|PILER-CR,CRT matches to NZ_CP029831 (Azospirillum ramasamyi strain M2T2B2 plasmid unnamed7, complete sequence) position: , mismatch: 9, identity: 0.719

ctgtcccatccgcacatcgtcaccgtgcacga	CRISPR spacer
aagtcccggccgcacatcgtcaccgaccagac	Protospacer
  *****. ****************  ** .

191. spacer 2.5|107220|32|NC_015951|PILER-CR,CRT matches to KX077895 (Streptococcus phage phiZJ20091101-4, complete genome) position: , mismatch: 9, identity: 0.719

-----tcgggggtccaccgctggacgcccttgccagc	CRISPR spacer
gactcttg-----ccacctctggacacccttgccagt	Protospacer
     *.*     ***** ******.**********.

192. spacer 2.6|107281|32|NC_015951|PILER-CR,CRT matches to NZ_CP048281 (Rhizobium leguminosarum bv. viciae 248 plasmid pRle248e, complete sequence) position: , mismatch: 9, identity: 0.719

catcagcaagatcctggagacgcccgacgggg	CRISPR spacer
ggtcctgaagaccctggagacgctcgacggtc	Protospacer
 .**   ****.***********.******

193. spacer 2.7|106976|32|NC_015951|CRISPRCasFinder matches to NZ_CP029831 (Azospirillum ramasamyi strain M2T2B2 plasmid unnamed7, complete sequence) position: , mismatch: 9, identity: 0.719

gacagaagatcgccgacaccgccctgcggctc	CRISPR spacer
ccaagggcatcgccgacaccttcctgcggctg	Protospacer
   **.. ************ .*********

194. spacer 2.7|106976|32|NC_015951|CRISPRCasFinder matches to NZ_CP006368 (Aureimonas sp. AU20 plasmid pAU20a, complete sequence) position: , mismatch: 9, identity: 0.719

gacagaagatcgccgacaccgccctgcggctc	CRISPR spacer
cggccaacgtcgccgacaacgccctgctgctc	Protospacer
 .   ** .********* ******** ****

195. spacer 2.7|106976|32|NC_015951|CRISPRCasFinder matches to NZ_CP029542 (Streptomyces sp. NEAU-S7GS2 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.719

gacagaagatcgccgacaccgccctgcggctc	CRISPR spacer
tcctggccatccccggcaccgccctgcggctg	Protospacer
  * *.  *** ***.***************

196. spacer 2.7|106976|32|NC_015951|CRISPRCasFinder matches to NZ_CP041606 (Streptomyces sp. S1D4-14 plasmid pS1D4-14.2, complete sequence) position: , mismatch: 9, identity: 0.719

gacagaagatcgccgacaccgccctgcggctc	CRISPR spacer
ccgggagcgtcgccgacaccgcgctgcgcctc	Protospacer
   .**. .************* ***** ***

197. spacer 2.8|107038|31|NC_015951|CRISPRCasFinder matches to MN096370 (Gordonia phage Squiddly, complete genome) position: , mismatch: 9, identity: 0.71

cgaaaacagcacccgcctgggcggtggtgac	CRISPR spacer
ttgcagcagcccctgcctgggcggtggtggg	Protospacer
. . *.**** **.***************.

198. spacer 2.8|107038|31|NC_015951|CRISPRCasFinder matches to MK937597 (Gordonia phage Spooky, complete genome) position: , mismatch: 9, identity: 0.71

cgaaaacagcacccgcctgggcggtggtgac	CRISPR spacer
ttgcagcagcccctgcctgggcggtggtggg	Protospacer
. . *.**** **.***************.

199. spacer 2.11|107221|31|NC_015951|CRISPRCasFinder matches to KX077895 (Streptococcus phage phiZJ20091101-4, complete genome) position: , mismatch: 9, identity: 0.71

-----cgggggtccaccgctggacgcccttgccagc	CRISPR spacer
actcttg-----ccacctctggacacccttgccagt	Protospacer
     .*     ***** ******.**********.

200. spacer 3.1|116988|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to MN224564 (Streptomyces phage Araceli, complete genome) position: , mismatch: 9, identity: 0.719

tcagcaggatcgtcacgagcccggtccatgcc	CRISPR spacer
tcagcaggatcgtgacgaacccgagcccgagg	Protospacer
************* ****.****. **  .

201. spacer 3.1|116988|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to MH229863 (Streptomyces phage JackieB, complete genome) position: , mismatch: 9, identity: 0.719

tcagcaggatcgtcacgagcccggtccatgcc	CRISPR spacer
tcagcaggatcgtgacgaacccgagcccgagg	Protospacer
************* ****.****. **  .

202. spacer 3.1|116988|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to MH229862 (Streptomyces phage Henoccus, complete genome) position: , mismatch: 9, identity: 0.719

tcagcaggatcgtcacgagcccggtccatgcc	CRISPR spacer
tcagcaggatcgtgacgaacccgagcccgagg	Protospacer
************* ****.****. **  .

203. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NC_009469 (Acidiphilium cryptum JF-5 plasmid pACRY03, complete sequence) position: , mismatch: 9, identity: 0.719

caccacatcgacgaggcgacggtggcggcgag	CRISPR spacer
ggcgggttcgacgaggcggcggtggcggcggc	Protospacer
 .* .  ***********.***********.

204. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NC_012586 (Sinorhizobium fredii NGR234 plasmid pNGR234b, complete sequence) position: , mismatch: 9, identity: 0.719

caccacatcgacgaggcgacggtggcggcgag	CRISPR spacer
gccggcatcgacgaggcgacgctgacggccgt	Protospacer
  * .**************** **.**** .

205. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NC_012586 (Sinorhizobium fredii NGR234 plasmid pNGR234b, complete sequence) position: , mismatch: 9, identity: 0.719

caccacatcgacgaggcgacggtggcggcgag	CRISPR spacer
cagttgatcgacgaggcggcggtgccggccgc	Protospacer
** .  ************.***** **** .

206. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP017563 (Paraburkholderia sprentiae WSM5005 plasmid pl1WSM5005, complete sequence) position: , mismatch: 9, identity: 0.719

caccac-atcgacgaggcgacggtggcggcgag	CRISPR spacer
-gtgatggtcgacaaggcgacggtgccggcgaa	Protospacer
 .. *. .*****.*********** ******.

207. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP029232 (Sinorhizobium fredii CCBAU 45436 plasmid pSF45436b, complete sequence) position: , mismatch: 9, identity: 0.719

caccacatcgacgaggcgacggtggcggcgag	CRISPR spacer
gccggcatcgacgaggcgacgctgacggccgt	Protospacer
  * .**************** **.**** .

208. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP015881 (Ensifer adhaerens strain Casida A plasmid pCasidaAA, complete sequence) position: , mismatch: 9, identity: 0.719

----caccacatcgacgaggcgacggtggcggcgag	CRISPR spacer
gtgacgc----tcgacgagcccacggtggcggcgtt	Protospacer
    *.*    ******** * ************

209. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP030263 (Ensifer adhaerens strain Corn53 plasmid AA, complete sequence) position: , mismatch: 9, identity: 0.719

----caccacatcgacgaggcgacggtggcggcgag	CRISPR spacer
gtgacgc----tcgacgagcccacggtggcggcgtt	Protospacer
    *.*    ******** * ************

210. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP023068 (Ensifer sojae CCBAU 05684 plasmid pSJ05684b, complete sequence) position: , mismatch: 9, identity: 0.719

caccacatcgacgaggcgacggtggcggcgag	CRISPR spacer
cagatgatcgacgaggcgaaggcggcggccga	Protospacer
**    ************* **.****** ..

211. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP054620 (Azospirillum oryzae strain KACC 14407 plasmid unnamed5, complete sequence) position: , mismatch: 9, identity: 0.719

caccacatcgacgaggcgacggtggcggcgag	CRISPR spacer
tgctcgaccgccgcggcgacggtggcggcgat	Protospacer
..*.  *.** ** *****************

212. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP023738 (Methylosinus trichosporium OB3b plasmid pOB3b1, complete sequence) position: , mismatch: 9, identity: 0.719

caccacatcgacgaggcgacggtggcggcgag	CRISPR spacer
gtcgagcccgacgaggcgccggaggcggcgat	Protospacer
  * *  .********** *** ********

213. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to MN234195 (Mycobacterium phage Xula, complete genome) position: , mismatch: 9, identity: 0.719

----caccacatcgacgaggcgacggtggcggcgag	CRISPR spacer
tggatgcc----cgacgaggcgacgatcgcggcgat	Protospacer
    ..**    *************.* *******

214. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to MH744423 (Mycobacterium phage Saguaro, complete genome) position: , mismatch: 9, identity: 0.719

caccacatcgacgaggcgacggtggcggcgag	CRISPR spacer
atccacatcgacgaggcggcgctggagcggga	Protospacer
  ****************.** *** *  *..

215. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NC_023498 (Mycobacterium phage Validus, complete genome) position: , mismatch: 9, identity: 0.719

caccacatcgacgaggcgacggtggcggcgag	CRISPR spacer
aacgtcatcgacgacgcgacggtcgcggttct	Protospacer
 **  ********* ******** ****.

216. spacer 3.5|117232|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to MN813687 (Mycobacterium phage Onyinye, complete genome) position: , mismatch: 9, identity: 0.719

ccgcactggaagaccagcgcctggaccgcctc	CRISPR spacer
accttgcggaagaccagcgcctggtcagcctg	Protospacer
 * .  .***************** * ****

217. spacer 3.5|117232|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP032827 (Sphingomonas sp. YZ-8 plasmid unnamed2, complete sequence) position: , mismatch: 9, identity: 0.719

ccgcactggaagaccagcgcctggaccgcctc	CRISPR spacer
acgcactggaggaccagcgccagggtctcgat	Protospacer
 *********.********** **..* *  .

218. spacer 3.5|117232|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP006990 (Rhizobium sp. IE4771 plasmid pRetIE4771d, complete sequence) position: , mismatch: 9, identity: 0.719

ccgcactggaagaccagcgcctggaccgcctc	CRISPR spacer
taccgctggaagaccaatgcctggaccggccg	Protospacer
.  *.***********..********** *.

219. spacer 3.7|117351|32|NC_015951|CRISPRCasFinder,CRT matches to NZ_CP013855 (Pseudonocardia sp. HH130630-07 plasmid pLS2-1, complete sequence) position: , mismatch: 9, identity: 0.719

aatcgggacccccgcgaccgtgcgaccggccc	CRISPR spacer
cgcgacgaccaccgcgaccgtgcggccggcgc	Protospacer
 .. . **** *************.***** *

220. spacer 3.7|117351|32|NC_015951|CRISPRCasFinder,CRT matches to NZ_CP011869 (Pseudonocardia sp. HH130629-09 plasmid pLS1-1, complete sequence) position: , mismatch: 9, identity: 0.719

aatcgggacccccgcgaccgtgcgaccggccc	CRISPR spacer
cgcgacgaccaccgcgaccgtgcggccggcgc	Protospacer
 .. . **** *************.***** *

221. spacer 3.8|117412|32|NC_015951|CRT matches to NC_016115 (Streptomyces pratensis ATCC 33331 plasmid pSFLA02, complete sequence) position: , mismatch: 9, identity: 0.719

ttcatcgcggcgaccaagaacgccgccgctca	CRISPR spacer
gccgtcgcggcggccaagaacggcgccacggt	Protospacer
 .*.********.********* ****.*

222. spacer 3.8|117412|32|NC_015951|CRT matches to NZ_CP018726 (Xanthomonas vesicatoria ATCC 35937 strain LMG911 plasmid pLMG911.1, complete sequence) position: , mismatch: 9, identity: 0.719

ttcatcgcggcgaccaagaacgccgccgctca	CRISPR spacer
aacacttgggcgaccaagaacgccgacggtcc	Protospacer
  **..  ***************** ** **

223. spacer 3.9|117473|31|NC_015951|CRT matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 9, identity: 0.71

cgcgctcggtgtacttggggccctcgccggg	CRISPR spacer
tcagggcggtgtgcttggtgccctcgccgcc	Protospacer
.  *  ******.***** **********

224. spacer 4.6|125935|35|NC_015951|CRISPRCasFinder matches to NZ_CP024424 (Paracoccus yeei strain TT13 plasmid pTT13-2, complete sequence) position: , mismatch: 9, identity: 0.743

ttccgtggggtcaaggacgaccagggcctgccgtg	CRISPR spacer
ctggccggggtcgaggacgacctgggcctgccctc	Protospacer
.*   .******.********* ********* *

225. spacer 4.6|125935|35|NC_015951|CRISPRCasFinder matches to NZ_CP020440 (Paracoccus yeei strain FDAARGOS_252 plasmid unnamed2, complete sequence) position: , mismatch: 9, identity: 0.743

ttccgtggggtcaaggacgaccagggcctgccgtg	CRISPR spacer
ctggccggggtcgaggacgacctgggcctgccctc	Protospacer
.*   .******.********* ********* *

226. spacer 4.6|125935|35|NC_015951|CRISPRCasFinder matches to NZ_CP044082 (Paracoccus yeei strain FDAARGOS_643 plasmid unnamed4, complete sequence) position: , mismatch: 9, identity: 0.743

ttccgtggggtcaaggacgaccagggcctgccgtg	CRISPR spacer
ctggccggggtcgaggacgacctgggcctgccctc	Protospacer
.*   .******.********* ********* *

227. spacer 1.1|104635|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP025962 (Rhodococcus qingshengii strain djl-6-2 plasmid pDJL3, complete sequence) position: , mismatch: 10, identity: 0.688

taccgcgccgtcaccggggccaccccgaactg	CRISPR spacer
acccgcgcagtcacctgggccacccacgtcga	Protospacer
  ****** ****** *********  . * .

228. spacer 1.2|104696|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP033873 (Caulobacter sp. FWC26 plasmid p1, complete sequence) position: , mismatch: 10, identity: 0.688

cacatcgcgctcgcgccccgcacgagcagcac	CRISPR spacer
aaagcggcgctcgcgcccagcacgaccaggct	Protospacer
 * .. ************ ****** ***  .

229. spacer 1.4|104818|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP015095 (Pelagibaca abyssi strain JLT2014 plasmid pPABY4, complete sequence) position: , mismatch: 10, identity: 0.688

tccgcaggtcggccccgtggtcaacggtcaga	CRISPR spacer
cgcgcaggtcggcccgctggtcaacttccgcc	Protospacer
. *************  ********  .*.

230. spacer 1.4|104818|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP029834 (Azospirillum ramasamyi strain M2T2B2 plasmid unnamed4, complete sequence) position: , mismatch: 10, identity: 0.688

tccgcaggtcggccccgtggtcaacggtcaga	CRISPR spacer
gacgcaggtcgacaccgtggtcaacatctcca	Protospacer
  *********.* ***********. ..  *

231. spacer 1.4|104818|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP040822 (Paraoceanicella profunda strain D4M1 plasmid pD4M1D, complete sequence) position: , mismatch: 10, identity: 0.688

tccgcaggtcggccccgtggtcaacggtcaga	CRISPR spacer
gcagcaggtcggctccgtggtcgacgccgccc	Protospacer
 * **********.********.*** .

232. spacer 2.2|107037|32|NC_015951|PILER-CR,CRT matches to MN096370 (Gordonia phage Squiddly, complete genome) position: , mismatch: 10, identity: 0.688

acgaaaacagcacccgcctgggcggtggtgac	CRISPR spacer
gttgcagcagcccctgcctgggcggtggtggg	Protospacer
.. . *.**** **.***************.

233. spacer 2.2|107037|32|NC_015951|PILER-CR,CRT matches to MK937597 (Gordonia phage Spooky, complete genome) position: , mismatch: 10, identity: 0.688

acgaaaacagcacccgcctgggcggtggtgac	CRISPR spacer
gttgcagcagcccctgcctgggcggtggtggg	Protospacer
.. . *.**** **.***************.

234. spacer 2.7|106976|32|NC_015951|CRISPRCasFinder matches to NZ_CP013855 (Pseudonocardia sp. HH130630-07 plasmid pLS2-1, complete sequence) position: , mismatch: 10, identity: 0.688

gacagaagatcgccgacaccgccctgcggctc	CRISPR spacer
acgccgagctcgccgacgccgccctgcgggtg	Protospacer
.    .** ********.*********** *

235. spacer 2.7|106976|32|NC_015951|CRISPRCasFinder matches to NZ_CP029777 (Deinococcus actinosclerus strain Deinococcus actinosclerus SJTR plasmid unnamed3, complete sequence) position: , mismatch: 10, identity: 0.688

gacagaagatcgccgacaccgccctgcggctc	CRISPR spacer
gcactcttctcgccgtcaccgccctgctgctc	Protospacer
*        ****** *********** ****

236. spacer 2.7|106976|32|NC_015951|CRISPRCasFinder matches to MH727545 (Mycobacterium phage DismalStressor, complete genome) position: , mismatch: 10, identity: 0.688

gacagaagatcgccgacaccgccctgcggctc	CRISPR spacer
tgtacaagagcgccgacaccgcgctgcgctcg	Protospacer
 ..* **** ************ ***** ..

237. spacer 2.7|106976|32|NC_015951|CRISPRCasFinder matches to NC_026598 (Mycobacterium phage Milly, complete genome) position: , mismatch: 10, identity: 0.688

gacagaagatcgccgacaccgccctgcggctc	CRISPR spacer
tgtacaagagcgccgacaccgcgctgcgctcg	Protospacer
 ..* **** ************ ***** ..

238. spacer 2.7|106976|32|NC_015951|CRISPRCasFinder matches to KX688047 (Mycobacterium phage Marcoliusprime, complete genome) position: , mismatch: 10, identity: 0.688

gacagaagatcgccgacaccgccctgcggctc	CRISPR spacer
tgtacaagagcgccgacaccgcgctgcgctcg	Protospacer
 ..* **** ************ ***** ..

239. spacer 2.7|106976|32|NC_015951|CRISPRCasFinder matches to MF140408 (Mycobacterium phage DismalFunk, complete genome) position: , mismatch: 10, identity: 0.688

gacagaagatcgccgacaccgccctgcggctc	CRISPR spacer
tgtacaagagcgccgacaccgcgctgcgctcg	Protospacer
 ..* **** ************ ***** ..

240. spacer 2.7|106976|32|NC_015951|CRISPRCasFinder matches to MF140411 (Mycobacterium phage Findley, complete genome) position: , mismatch: 10, identity: 0.688

gacagaagatcgccgacaccgccctgcggctc	CRISPR spacer
tgtacaagagcgccgacaccgcgctgcgctcg	Protospacer
 ..* **** ************ ***** ..

241. spacer 3.2|117049|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP035424 (Leisingera sp. NJS204 plasmid unnamed7, complete sequence) position: , mismatch: 10, identity: 0.688

gagatggccaagggcgggcagccccaggcgat	CRISPR spacer
ggcgcggccaggggcgggcagccgcagggccg	Protospacer
*. ..*****.************ ****

242. spacer 3.2|117049|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP026091 (Ralstonia solanacearum strain IBSBF 2570 plasmid unnamed, complete sequence) position: , mismatch: 10, identity: 0.688

gagatggccaagggcgggcagccccaggcgat	CRISPR spacer
ggcctggccaagggcgggccgcaccagcgagc	Protospacer
*.  *************** ** ****  ...

243. spacer 3.2|117049|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NC_014309 (Ralstonia solanacearum CFBP2957 plasmid RCFBPv3_mp, complete genome) position: , mismatch: 10, identity: 0.688

gagatggccaagggcgggcagccccaggcgat	CRISPR spacer
ggcctggccaagggcgggccgcaccagcgagc	Protospacer
*.  *************** ** ****  ...

244. spacer 3.2|117049|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP038236 (Leisingera sp. NJS201 plasmid unnamed2, complete sequence) position: , mismatch: 10, identity: 0.688

gagatggccaagggcgggcagccccaggcgat	CRISPR spacer
ggcgcggccaggggcgggcagccgcagggccg	Protospacer
*. ..*****.************ ****

245. spacer 3.2|117049|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP026093 (Ralstonia solanacearum strain SFC plasmid unnamed, complete sequence) position: , mismatch: 10, identity: 0.688

gagatggccaagggcgggcagccccaggcgat	CRISPR spacer
ggcctggccaagggcgggccgcaccagcgagc	Protospacer
*.  *************** ** ****  ...

246. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NC_016586 (Azospirillum lipoferum 4B plasmid AZO_p2, complete sequence) position: , mismatch: 10, identity: 0.688

caccacatcgacgaggcgacggtggcggcgag	CRISPR spacer
ggtgtgacggacgaggcgtcgttggcggcgag	Protospacer
 ..   *. ********* ** **********

247. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP032326 (Azospirillum brasilense strain MTCC4035 plasmid p5, complete sequence) position: , mismatch: 10, identity: 0.688

caccacatcgacgaggcgacggtggcggcgag	CRISPR spacer
ctggtgctcgacgaggccacggcggcggcgga	Protospacer
*      ********** ****.*******..

248. spacer 3.3|117110|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NC_030931 (Pseudomonas phage phi2, complete genome) position: , mismatch: 10, identity: 0.688

caccacatcgacgaggcgacggtggcggcgag	CRISPR spacer
gaaatggtcgacgaggcgctggtggcggcgga	Protospacer
 *    .*********** .**********..

249. spacer 3.4|117171|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP011515 (Mitsuaria sp. 7 plasmid, complete sequence) position: , mismatch: 10, identity: 0.688

ggtgccggtcgcgtggttgatctggcggatgg	CRISPR spacer
atcgccggtcgcggcgttgatctggctcgcgt	Protospacer
. .**********  ***********  ..*

250. spacer 3.5|117232|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP053440 (Rhizobium leguminosarum bv. trifolii strain CC275e plasmid pRltCC275eF, complete sequence) position: , mismatch: 10, identity: 0.688

ccgcactggaagaccagcgcctggaccgcctc	CRISPR spacer
ttgagttggaagaccaccgccttgaccgcaag	Protospacer
..* ..********** ***** ******

251. spacer 3.5|117232|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP054028 (Rhizobium sp. JKLM19E plasmid pPR19E01, complete sequence) position: , mismatch: 10, identity: 0.688

ccgcactggaagaccagcgcctggaccgcctc	CRISPR spacer
tatggctggaagacgagcgactggaccggccg	Protospacer
.   .********* **** ******** *.

252. spacer 3.5|117232|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NC_009620 (Sinorhizobium medicae WSM419 plasmid pSMED01, complete sequence) position: , mismatch: 10, identity: 0.688

ccgcactggaagaccagcgcctggaccgcctc	CRISPR spacer
gcggactggatgaccagcgcctggggccagaa	Protospacer
 ** ****** *************. *

253. spacer 3.5|117232|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NC_047890 (Escherichia phage PGT2, complete genome) position: , mismatch: 10, identity: 0.688

ccgcactggaagaccagcgcctggaccgcctc	CRISPR spacer
ttagaccggaagaccagcggctggaccaatcc	Protospacer
... **.************ *******. ..*

254. spacer 3.8|117412|32|NC_015951|CRT matches to NZ_CP032053 (Streptomyces clavuligerus strain F1D-5 plasmid pSCL2, complete sequence) position: , mismatch: 10, identity: 0.688

ttcatcgcggcgaccaagaacgccgccgctca	CRISPR spacer
ccgggggcggcgaggaagaacgccgccgcccc	Protospacer
.. .  *******  **************.*

255. spacer 3.8|117412|32|NC_015951|CRT matches to NZ_CP032053 (Streptomyces clavuligerus strain F1D-5 plasmid pSCL2, complete sequence) position: , mismatch: 10, identity: 0.688

ttcatcgcggcgaccaagaacgccgccgctca	CRISPR spacer
ccggaggcggcgaggaagaacgccgccgcccc	Protospacer
.. .  *******  **************.*

256. spacer 3.8|117412|32|NC_015951|CRT matches to NZ_CP023408 (Streptomyces fungicidicus strain TXX3120 plasmid p1, complete sequence) position: , mismatch: 10, identity: 0.688

ttcatcgcggcgaccaagaacgccgccgctca	CRISPR spacer
aacgacgcggcgaccaagaaggtcgccgactt	Protospacer
  *. *************** *.***** ..

257. spacer 4.1|125630|37|NC_015951|CRISPRCasFinder matches to NZ_CP029832 (Azospirillum ramasamyi strain M2T2B2 plasmid unnamed2, complete sequence) position: , mismatch: 10, identity: 0.73

catctgaccggaggcgcccagtgaccgcaggcgtcct	CRISPR spacer
gcactgaccggaggcgcccgatgaccgcaaccgcctc	Protospacer
   ****************..********. **.*..

258. spacer 1.2|104696|32|NC_015951|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP014705 (Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence) position: , mismatch: 11, identity: 0.656

cacatcgcgctcgcgccccgcacgagcagcac	CRISPR spacer
tggcgagcgctcgcgccgcgcacgagaaggcg	Protospacer
..    *********** ******** **

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

104999 : 148846

Escherichia_phage(20.0%)

transposase,integrase

attL 134909:134928|attR 151976:151995

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014043534.1\|104999_106613_-\|transposase	ISL3 family transposase	A0A2L1IVA1	Escherichia_phage	1.2e-05	31.0
WP_078505979.1\|107359_107692_-	type I-E CRISPR-associated endoribonuclease Cas2	NA	NA	NA	NA
WP_014043535.1\|108625_109270_-	type I-E CRISPR-associated protein Cas6/Cse3/CasE	NA	NA	NA	NA
WP_014043536.1\|109266_110130_-	type I-E CRISPR-associated protein Cas5/CasD	NA	NA	NA	NA
WP_014043537.1\|110126_111302_-	type I-E CRISPR-associated protein Cas7/Cse4/CasC	NA	NA	NA	NA
WP_106686061.1\|111458_112052_-	type I-E CRISPR-associated protein Cse2/CasB	NA	NA	NA	NA
WP_014043539.1\|112147_113758_-	type I-E CRISPR-associated protein Cse1/CasA	NA	NA	NA	NA
WP_063644483.1\|114015_116835_-	CRISPR-associated helicase/endonuclease Cas3	NA	NA	NA	NA
WP_014043541.1\|117785_118340_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_014043542.1\|118450_119407_+	NADP-dependent oxidoreductase	NA	NA	NA	NA
WP_014043543.1\|119637_120231_-	M15 family metallopeptidase	NA	NA	NA	NA
WP_150112974.1\|120378_120573_-	hypothetical protein	NA	NA	NA	NA
WP_014043544.1\|120869_121121_-	type II toxin-antitoxin system RelE/ParE family toxin	NA	NA	NA	NA
WP_014043545.1\|121117_121375_-	type II toxin-antitoxin system Phd/YefM family antitoxin	NA	NA	NA	NA
WP_167543316.1\|121936_122107_-	hypothetical protein	NA	NA	NA	NA
WP_043242275.1\|122223_123567_+	recombinase	NA	NA	NA	NA
WP_167543317.1\|123876_124050_+	site-specific DNA-methyltransferase	NA	NA	NA	NA
WP_014043547.1\|124157_125429_+\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	5.0e-31	35.8
WP_043242280.1\|126302_127844_+\|transposase	IS21 family transposase	NA	NA	NA	NA
WP_050994194.1\|128032_128758_+	ATP-binding protein	K4HZD4	Acidithiobacillus_phage	1.6e-13	29.4
WP_014043550.1\|128769_129174_-	hypothetical protein	NA	NA	NA	NA
WP_106686045.1\|129860_130826_-	adenosine deaminase	NA	NA	NA	NA
WP_014043552.1\|131420_131834_-	hypothetical protein	NA	NA	NA	NA
WP_167543318.1\|131930_133388_-\|integrase	site-specific integrase	NA	NA	NA	NA
WP_014043554.1\|133487_133790_+	hypothetical protein	NA	NA	NA	NA
WP_014043555.1\|133782_134055_+	hypothetical protein	NA	NA	NA	NA
134909:134928	attL	NA	NA	NA	NA
WP_043242286.1\|134993_135254_-	hypothetical protein	NA	NA	NA	NA
WP_014043557.1\|135473_136298_-	hypothetical protein	NA	NA	NA	NA
WP_014043558.1\|136299_136845_-	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_167543319.1\|136880_137045_-	hypothetical protein	NA	NA	NA	NA
WP_150112975.1\|137535_137994_-	hypothetical protein	NA	NA	NA	NA
WP_014043561.1\|138515_139796_+	hypothetical protein	NA	NA	NA	NA
WP_043242437.1\|140053_140743_-	HNH endonuclease	A0A1S6L216	Vibrio_phage	8.0e-15	36.2
WP_014043563.1\|140946_141174_+	hypothetical protein	NA	NA	NA	NA
WP_014043564.1\|141621_141822_-	hypothetical protein	NA	NA	NA	NA
WP_014043566.1\|142234_143152_-	alpha/beta hydrolase	A0A0G2YDK2	Acanthamoeba_polyphaga_mimivirus	7.9e-10	27.6
WP_014043567.1\|143185_143611_-	hypothetical protein	NA	NA	NA	NA
WP_014043568.1\|143607_145779_-\|integrase	integrase	NA	NA	NA	NA
WP_014043569.1\|145775_147494_-	hypothetical protein	NA	NA	NA	NA
WP_086019724.1\|147493_148846_-\|integrase	site-specific integrase	NA	NA	NA	NA
151976:151995	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

3. NC_015952

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NC_015952_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015952_1

169929-170153

Orphan

Consensus_repeat	Method
CGGCATCACCGAGGCGAAGGCCAAGGAGATCGCCGACGCCGCGGCGAAGGC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_015952_1

>merge|NC_015952|1|169929-170153|CRISPRCasFinder
CGGCATCACCGAGGCGAAGGCCAAGGAGATCGCCGACGCCGCGGCGAAGGCGGCCGTGGACGCCTACGCGGCCAAGGACACCAACGGCGGCATCACCGAGGCGAAGGCCAAGGAGATCGCCGACGCCGCGGCGAAGGCCGCGATCGACGAGTACGCCAAGAACAACCCTGGCGGCGGCATCACCGAGGCGAAGGCCAAGGAGATCGCCGACGCCGCGGCGAAGGC

>NC_015952|1|1|169929-170153|CRISPRCasFinder
CGGCATCACCGAGGCGAAGGCCAAGGAGATCGCCGACGCCGCGGCGAAGGC	GGCCGTGGACGCCTACGCGGCCAAGGACACCAACGG
CGGCATCACCGAGGCGAAGGCCAAGGAGATCGCCGACGCCGCGGCGAAGGC	CGCGATCGACGAGTACGCCAAGAACAACCCTGGCGG
CGGCATCACCGAGGCGAAGGCCAAGGAGATCGCCGACGCCGCGGCGAAGGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015952.1\|WP_014043932.1\|168442_168694_+\|hypothetical-protein	unknown	unknown	unknown
NC_015952.1\|WP_014043936.1\|171706_172939_-\|beta-ketoacyl-[acyl-carrier-protein]-synthase-family-protein	unknown	unknown	gnl\|CDD\|238430
NC_015952.1\|WP_014043939.1\|174689_175538_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|379263
NC_015952.1\|WP_014043931.1\|168063_168291_-\|hypothetical-protein	unknown	unknown	unknown
NC_015952.1\|WP_106686074.1\|173213_174350_-\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|369640
NC_015952.1\|WP_014043928.1\|165627_166554_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340831
NC_015952.1\|WP_014043941.1\|177324_178068_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367638
NC_015952.1\|WP_014043926.1\|164325_164610_+\|hypothetical-protein	unknown	unknown	unknown
NC_015952.1\|WP_167543333.1\|163350_163491_-\|hypothetical-protein	unknown	unknown	unknown
NC_015952.1\|WP_014043944.1\|179864_181232_+\|hypothetical-protein	unknown	unknown	unknown
NC_015952.1\|WP_167543335.1\|168713_169709_-\|glycosyltransferase-family-1-protein	unknown	unknown	gnl\|CDD\|379238
NC_015952.1\|WP_014043942.1\|178083_178518_-\|3-Oxoacyl-(acyl-carrier-protein-(ACP))-synthase-III-domain-containing-protein	unknown	unknown	gnl\|CDD\|337099
NC_015952.1\|WP_014043943.1\|178554_179553_-\|ketoacyl-ACP-synthase-III	unknown	unknown	gnl\|CDD\|236475
NC_015952.1\|WP_014043935.1\|171361_171619_+\|hypothetical-protein	unknown	unknown	unknown
NC_015952.1\|WP_167543334.1\|166556_167117_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379276
NC_015952.1\|WP_014043937.1\|172944_173190_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|240304
NC_015952.1\|WP_014043940.1\|175528_177328_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|173839
NC_015952.1\|WP_014043927.1\|164580_165588_-\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340831
NC_015952.1\|WP_014043925.1\|163632_164262_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|185628
NC_015952.1\|WP_014043930.1\|167320_167869_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_015952.1\|WP_014043939.1\|174689_175538_-\|SDR-family-oxidoreductase	gnl\|CDD\|379263	pfam13561, adh_short_C2, Enoyl-(Acyl carrier protein) reductase.	2.59439e-67
NC_015952.1\|WP_014043928.1\|165627_166554_-\|glycosyltransferase	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	4.92993e-10
NC_015952.1\|WP_014043925.1\|163632_164262_+\|hypothetical-protein	gnl\|CDD\|185628	PTZ00449, PTZ00449, 104 kDa microneme/rhoptry antigen; Provisional.	0.00470179
NC_015952.1\|WP_014043941.1\|177324_178068_-\|hypothetical-protein	gnl\|CDD\|367638	pfam03756, AfsA, A-factor biosynthesis hotdog domain. The AfsA family are key enzymes in A-factor biosynthesis, which is essential for streptomycin production and resistance. This domain is distantly related to the thioester dehydratase FabZ family and therefore has a HotDog domain.	1.11663e-11
NC_015952.1\|WP_014043927.1\|164580_165588_-\|glycosyltransferase-family-4-protein	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	6.36902e-32
NC_015952.1\|WP_106686074.1\|173213_174350_-\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|369640	pfam07993, NAD_binding_4, Male sterility protein. This family represents the C-terminal region of the male sterility protein in a number of arabidopsis and drosophila. A sequence-related jojoba acyl CoA reductase is also included.	6.61332e-40
NC_015952.1\|WP_014043942.1\|178083_178518_-\|3-Oxoacyl-(acyl-carrier-protein-(ACP))-synthase-III-domain-containing-protein	gnl\|CDD\|337099	pfam08541, ACP_syn_III_C, 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal. This domain is found on 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III EC:2.3.1.41, the enzyme responsible for initiating the chain of reactions of the fatty acid synthase in plants and bacteria.	1.97111e-19
NC_015952.1\|WP_014043943.1\|178554_179553_-\|ketoacyl-ACP-synthase-III	gnl\|CDD\|236475	PRK09352, PRK09352, beta-ketoacyl-ACP synthase 3.	2.52491e-108
NC_015952.1\|WP_167543334.1\|166556_167117_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379276	pfam13578, Methyltransf_24, Methyltransferase domain. This family appears to be a methyltransferase domain.	5.97894e-17
NC_015952.1\|WP_014043937.1\|172944_173190_-\|hypothetical-protein	gnl\|CDD\|240304	PTZ00171, PTZ00171, acyl carrier protein; Provisional.	0.000279805
NC_015952.1\|WP_014043940.1\|175528_177328_-\|hypothetical-protein	gnl\|CDD\|173839	cd01150, AXO, Peroxisomal acyl-CoA oxidase. Peroxisomal acyl-CoA oxidases (AXO) catalyze the first set in the peroxisomal fatty acid beta-oxidation, the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. In a second oxidative half-reaction, the reduced FAD is reoxidized by molecular oxygen. AXO is generally a homodimer, but it has been reported to form a different type of oligomer in yeast. There are several subtypes of AXO's, based on substrate specificity. Palmitoyl-CoA oxidase acts on straight-chain fatty acids and prostanoids; whereas, the closely related Trihydroxycoprostanoly-CoA oxidase has the greatest activity for 2-methyl branched side chains of bile precursors. Pristanoyl-CoA oxidase, acts on 2-methyl branched fatty acids. AXO has an additional domain, C-terminal to the region with similarity to acyl-CoA dehydrogenases, which is included in this alignment.	1.12077e-23
NC_015952.1\|WP_014043936.1\|171706_172939_-\|beta-ketoacyl-[acyl-carrier-protein]-synthase-family-protein	gnl\|CDD\|238430	cd00834, KAS_I_II, Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP.	3.23049e-153
NC_015952.1\|WP_167543335.1\|168713_169709_-\|glycosyltransferase-family-1-protein	gnl\|CDD\|379238	pfam13524, Glyco_trans_1_2, Glycosyl transferases group 1.	1.53922e-21

>NC_015952.1|WP_167543335.1|168713_169709_-|glycosyltransferase-family-1-protein
MRIVFLGNFAVHWSSETYWAHSLEDLGHEVTRLQVTQASAEEILARGRAADLLVWVHTPGGRTPGALGMEQVLAELRAAEIPTVSYHLDLWAPLPRAEQVGRDLIYRHIEHFFSVDPGLVDWFGRQTQVKGHYLPAGVYGGDCRMVERTPVDGGGFPHEVVFVGGRYNYPPQWPYRGELVDWLEGTYGERFTHFGVDGTAEVYGAALNQLYANTKIVVGDTLCPGFDYAGYWSDRIYETIGRGGFMIHPYIPGLEEQFTDGRHLKFYTYGDFGELRELIEHYLTHGEEREAIRRAGFEHVRDNHTYAHRWKAILEAVTGARAPSGGTEPAL
>NC_015952.1|WP_014043932.1|168442_168694_+|hypothetical-protein
MKTTARILCTAAIAVTALPLAAGAAAAASTLPSIGAETPANAIGDLTSGTLVGKTAQTAGTLDPASGITAPLDSLTGSLPLSR
>NC_015952.1|WP_014043931.1|168063_168291_-|hypothetical-protein
MTGTLNGCILVSNVGLLEGTRMGAQQGDSQGEQRIVVVVRNETAEQSKSGPTAARLEWWFIPGLLLFATIVSLLR
>NC_015952.1|WP_014043930.1|167320_167869_-|hypothetical-protein
MNLATVDPDGVTRSLAVIVQSLDRCRHGRHVVDPCGSCPNGLSEGNPHLKPGQKVGYDVHGETLYVPGPDHLSDARAWRTLPKDAAAGDDPLLNRAYRERNRLVAGYTRHWPSVITEAPDYPGFWIVYLVSPAGQLSWHIPQEDMDLFKHVRRVDTWAWDGHTTQQKYERLNAACAMWEGRA
>NC_015952.1|WP_167543334.1|166556_167117_-|class-I-SAM-dependent-methyltransferase
MKTLEVILQRELAGLRERSGKKALDVLEVGTIRETAEGARPADGWSTLFFAEHVAEHGGRVVGVDLDVSAARLVLQRHGVAEKVELVTGSSLEVLPRLVDEGASFDVIFLDSDNDPDLVMSEYEFALKLIRPGGLILADDVDQDDVWVRKGLKLIPYLKDSGVAFRIDRREASWGGRDVMIQEVKG
>NC_015952.1|WP_014043928.1|165627_166554_-|glycosyltransferase
MARVNLVSKDNDSGLSVDLKVMTEALKRLGHDVVWADFRDAGMRECDAAIFLETPSEALLSFARRTVFVPNPDCLDDDEIKLIDRFDHVWAKSQTMHRIAAELPVRHLVLTGFATPDRSRPKKRRKHTVLHMAGRSTAKNTAAVVEAWHRHGAELPPLAITADWDLSFLGLTLPQNAEHLGHVDRGEVANLLNTYAIHLLPSRAEGWGHGIVEGLLCGAQVVTTDADPMNAHVRPEFGWLLPAADEEMSGRVRCKRVDPEDVAVAVKEAAALPAKDRAARGRLGRAHALARNEAFHAAVRDAMGELLS
>NC_015952.1|WP_014043927.1|164580_165588_-|glycosyltransferase-family-4-protein
MRVVALVHFYPPYKLAGSETMLHTMLQSLQQAGHEVWAVTTDMPQAPEQWTYEGIRAFSERRQGHAVPLTRSLEPDVIVTHHTHAALGVQTARDFGIPSVLVQHNTFDEHRVVLAMKPDLTVFNTEWIARSWHSMLDGARWMVLHPPVWPHEHATRPGGAVTLVNLNAAKGVHIFGHLAMLFPDVPFLGVVGAYGEQVTAGLPPNVEVIGPTSDMRRQVWSRTRVLLMPSIYESYGMAAVEAMASGIPVIANPTLGLREALGPAGVYADRESMQEWATTLRGLVRDPLVWQQASAAAQARSQSLDPTNELWQWVKAVESLAPQPLASGSRGDRRA
>NC_015952.1|WP_014043926.1|164325_164610_+|hypothetical-protein
MWWSYVLALGGAGGFFMMRRGMWQGFATSTCMQALWTVYTVVSGQWGFLFGVALYGPMSIWGWYSWKRRGVPSPAAACTCPCACGSRAPVAPAA
>NC_015952.1|WP_014043925.1|163632_164262_+|hypothetical-protein
MHIKRLIPAVLTATALAISGCSAAPDDVSDHINTSRLNSHQKSVISVWYDVVDAQEKKRLEALSGHEVLSSVNAFTLLCAVDEDRIAAELVKYFHGVSKNGAARLADAIDDHLCEKPKTKTTKKPSASATASTPTTPKTPAAPSVDTNPTHDLTKPTSRHDREEMTLRAPANREPAKTHQHPAPEHRPQAPKPAPAAKAPAKSMAKSGR
>NC_015952.1|WP_167543333.1|163350_163491_-|hypothetical-protein
MRLHALGDVHAAVQEALRGPDSPLLIAALAAASGVSLCAGADLLLG
>NC_015952.1|WP_014043935.1|171361_171619_+|hypothetical-protein
MNTGHNGTRNGTDQGELGASSLKDKDGNTVALDKTATAASIGSHVSGSKYSYTLVYEYAKPNGLTGKVTSNAKDIDVDDPDCPKP
>NC_015952.1|WP_014043936.1|171706_172939_-|beta-ketoacyl-[acyl-carrier-protein]-synthase-family-protein
MALNIAITGIGMVTPAGLTTADTWAGILTGRSYATSDPLLKRLKTTISCRLPPHDFKAALGALLVRRTDPSARYAIIAAREALTHAQLDPQRWNARRVAIVLGTAAAGISTVEHSHHVLNTKGAHHVPPSALPAFLPNMAAGHLSMAIGAQGPVMTVSSACASGSTAIGHAARLLAQQDCDIAIAGGTDAMVTPLCAAGFGQLGALSTRNHDPDGASRPFDADHDGFVLAEGAAILILERLTDARARGAPITAVIDGYGECADAHHPTAPQPGGVGSEYALREALRTAGATEADVDHVNAHGTSTPLGDATEAAMLARTLTSDFTVTSNKGALGHTMGAAGAIEAALTALAIRHQTIPPTANHHKPAQGCEDIRIIRGRPHPQLVRLAVSTSLGFGGHNAVLALRPAPDH
>NC_015952.1|WP_014043937.1|172944_173190_-|hypothetical-protein
MSNDDVINHIIHLLAESFEVERAAIEPTATLADLDLDSLAVVEFNVALGEYYDVPLGDSDSDKIPLTLIAEKVTALVRQKD
>NC_015952.1|WP_106686074.1|173213_174350_-|NAD-dependent-epimerase/dehydratase-family-protein
MKRTHVITGATGLLGAALVLQLAARTSADDLICLVRPADSDPQKRLTAALSEAAKAYRTDALTTQRALRKAKAVSADLTLPGLGLDSIQVASPYPTWFWHVGALIGFGHANRRRLFATNTAGTRRIVDLATQMKAEALHYVSTAYVAGSRTGEIPEQPITDAVPREFYEASKIAAERIVWNAPLPTRIYRPTAIIGHHATYACGGPYTGVYGLMRRIALHQSLRHRLDGGRHPIRLLARGDLPLNLVPVDHVARELVEIAHASTPHRVFHLSNPTPPTVGATLRAIFTQLGIAAWELVDDPALLHPADLHLAELFREFYADYLNHEHRFRRDHAHAALLQPARTQYPMDDDLLNQFFAHYHRHELARRHPVPATRKPA
>NC_015952.1|WP_014043939.1|174689_175538_-|SDR-family-oxidoreductase
MPVTDLPAPFRLDGLRALITGASRGIGQAIAATFAEAGAELALSARTTQALKPTSDLLNGHNPKRVLIGADLADRGAAEQTVNEAAAALGGLDIIVHNAGTLPQDDDGNPILAPLHKTRQRDFEHVVSVNLNATAALARAAHPHLERSDNASLVIMSSAAAVSGCPGMDAYAATKAAQLALTRSLAVGWARTGIRVNALCPGWVATDMTAAVKNVSAISDWLMAHVPLGRWATPQECAYAALYLASPASSFMTGHAMALDGGLTISEGGLAGIPKPPSPFVS
>NC_015952.1|WP_014043940.1|175528_177328_-|hypothetical-protein
MTAERDLAAVAGTTSDSTLERLDALLAKDVFQPHTGAVDHHHRTYARLRLLLQELGGPSALNADAPTLLTAMGWAAQVDPPLYIALLTTAIACMGPMLDLGEPSDYLQELIGEIDSGRRHGAVLTTELGHGCSHINPGTEARYNQAERTFTLHTPHPDHVKIMGNVALPGQASAAVVYAQLIVDGQPRGVYPFAIRVREEHHTPPTLHIRTVGDVTLLPLDYATVRFEQHTIPYGAWLAGGARIDRDGSFHDAHDPGARLVRSWRSALTIAAGTTEALAAAARAACTITHHAMAHRPTQGMPHPGATVADYSLQQHALAASVLDTITAGLLARRARTLHAQPHDSAVPAAVTWAPWVAAHRDLALLKARARDLAEAAVARLRPRLGAHGTLATNQLTAYEGMAQVVEAATGDKVSILLEAGKDLLASDSFPDGTGTLGRARAREHLLRRAVRRAVGARNISSEKPAAFAVYNPHLPALVELAEARADCLMLAAVDQAVQASLPLDTDLAAAVQAVAHLAETTYLTRHLGFLLAHRLIPSSEAKVLPERHIGALNAVAAHLPVLIASFTVPAARTAAPITYPDYAERLTGWTFKETSPCL
>NC_015952.1|WP_014043941.1|177324_178068_-|hypothetical-protein
MPSDPQSLWLIGESFHRATVHPQFVTQDQLLTRLRTEQPPVPLIVRPGLGIDPVSWHDLRMILGKEIDVTFEGEPPLAVPRRHVLKHCVDNVVIGDAAVDGNAFRAQLVVPNDTEMLRDHSADQQHVPGLLLIEAATQIVTWAAAQLTEPLPGQPPRYAVMHACDFDFRRFVFPLPATLTGTLEIDGEPQKERIPLRSTVTVTQNGRVCSRLGLRLHAFDRTCIFAVEHSQALATLADASGIPGESA
>NC_015952.1|WP_014043942.1|178083_178518_-|3-Oxoacyl-(acyl-carrier-protein-(ACP))-synthase-III-domain-containing-protein
MEHKAPIGVLGCGSYLPAERRSNEQVSRDAGVSAEWIHSRTGVKSRRIAAPHEAASDLAQGAQPNPLLLRQVAGEFGIEPRRLVVVGEDIGNIGAACIPYALSKYASEGRFSCGDRILIASFGAGFTWGHALLTWGSSSAVRTH
>NC_015952.1|WP_014043943.1|178554_179553_-|ketoacyl-ACP-synthase-III
MERKAPIGVLGCGSYLPAERRSNEQVARQAGVSAEWIHSHTGVKSRWAAAEDEAASDLALGALRSALAAAEIEADQLGLIILATSTPDDLGPSTACRVQHAIKATRAVALDVAAACSGWLFAARVAHDWLRQDPSIGYAAVIGVEAYSKFINPADRATASLFGDGAAATILGPVPAPYGFGPFTLGSDGGLADVVGIPGGGSRQPDGDHTIHMKGRIVRDFVVNNLPGIIDDALKQHRITMGDVDHFVTHQPNPLLLRQVAEKVGIPATRLVVIGEDVGNIGAACIPYALTQGASQGRFAQGDLVLIAGFGAGFTWGSTLLTWNTSSAVCML
>NC_015952.1|WP_014043944.1|179864_181232_+|hypothetical-protein
MGRAGRNERLAALLAEAQWNSAELARAIVALGRAQGLTISYDRTAPAHWLTGTRPRPPTPQLAAEAFTKRLKRLVTVSDTGLANEQPLTAQLLSASPPEANPLETVKELVTLCRTALDPTQGPVLARRPYAGPLPRAASWTAPASPPPTPTSHAGSLVLGDLTHTLSSLWTRNGGGQTQPLVLSFLAHAIRPEYLGEQPDLLAGYAQFAHLAAVTCIDCGQHGMAQRFFHTALHLSRHSGRRDLGAVTLRTMSAHALRLNYTEQAAELAQQAVDLDARQTSGALRSFVLAQRAVVLAAGGQSAEAVRDVKLMLHAWDDDSSSKPRPGPFTTYPRSGLDFQRSQVWRFLGEKDRAEQALHDALRMRAPVQRRPFALLHASLAELACEKGRIDVACRHWATFLDYYPYVWSAALEQALNRMHSSLAPYAEHDRASRLLTRAASLGDAAREQRRVDLP

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_015952_1	1.2\|170067\|36\|NC_015952\|CRISPRCasFinder	170067-170102	36	NC_015952.1	170154-170189	1	0.972

1. spacer 1.2|170067|36|NC_015952|CRISPRCasFinder matches to position: 170154-170189, mismatch: 1, identity: 0.972

cgcgatcgacgagtacgccaagaacaaccctggcgg	CRISPR spacer
cgcgatcgacgagtacgccaagaacaaccccggcgg	Protospacer
******************************.*****

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_015952_1	1.1\|169980\|36\|NC_015952\|CRISPRCasFinder	169980-170015	36	NC_015952	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI02, complete sequence	169980-170015	0	1.0
NC_015952_1	1.2\|170067\|36\|NC_015952\|CRISPRCasFinder	170067-170102	36	NC_015952	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI02, complete sequence	170067-170102	0	1.0
NC_015952_1	1.2\|170067\|36\|NC_015952\|CRISPRCasFinder	170067-170102	36	NC_015952	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI02, complete sequence	170154-170189	1	0.972
NC_015952_1	1.1\|169980\|36\|NC_015952\|CRISPRCasFinder	169980-170015	36	MT723933	Streptomyces phage Keanu, complete genome	42875-42910	5	0.861
NC_015952_1	1.1\|169980\|36\|NC_015952\|CRISPRCasFinder	169980-170015	36	MH588547	Caulobacter phage CcrSC, complete genome	203195-203230	9	0.75

1. spacer 1.1|169980|36|NC_015952|CRISPRCasFinder matches to NC_015952 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI02, complete sequence) position: , mismatch: 0, identity: 1.0

ggccgtggacgcctacgcggccaaggacaccaacgg	CRISPR spacer
ggccgtggacgcctacgcggccaaggacaccaacgg	Protospacer
************************************

2. spacer 1.2|170067|36|NC_015952|CRISPRCasFinder matches to NC_015952 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI02, complete sequence) position: , mismatch: 0, identity: 1.0

cgcgatcgacgagtacgccaagaacaaccctggcgg	CRISPR spacer
cgcgatcgacgagtacgccaagaacaaccctggcgg	Protospacer
************************************

3. spacer 1.2|170067|36|NC_015952|CRISPRCasFinder matches to NC_015952 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI02, complete sequence) position: , mismatch: 1, identity: 0.972

cgcgatcgacgagtacgccaagaacaaccctggcgg	CRISPR spacer
cgcgatcgacgagtacgccaagaacaaccccggcgg	Protospacer
******************************.*****

4. spacer 1.1|169980|36|NC_015952|CRISPRCasFinder matches to MT723933 (Streptomyces phage Keanu, complete genome) position: , mismatch: 5, identity: 0.861

ggccgtggacgcctacgcggccaaggacaccaacgg	CRISPR spacer
tgccgtgggcgtctacgcggccaaggacaccaacct	Protospacer
 *******.**.**********************

5. spacer 1.1|169980|36|NC_015952|CRISPRCasFinder matches to MH588547 (Caulobacter phage CcrSC, complete genome) position: , mismatch: 9, identity: 0.75

ggccgtggacgcctacgcggccaaggacaccaacgg	CRISPR spacer
ggagttcgacgcctacgcggccaagaacatcaatca	Protospacer
**   * ******************.***.***. .

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage