CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_014541	Ferrimonas balearica DSM 9799, complete sequence	3 crisprs	cas3,csa3,DEDDh,WYL,DinG	0	1	1	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_014541_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014541_1

1653245-1653350

Orphan

Consensus_repeat	Method
CCCTGTGGGATCCCTCCTGTCGGCATCC	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of NC_014541_1

>merge|NC_014541|1|1653245-1653350|CRISPRCasFinder
CCCTGTGGGATCCCTCCTGTCGGCATCCTTGTCTCTACCTCACCGAACTGCGATGCGTTGCATTGGTTCCGGTTCGCCCCCTGTGGGATCCCTCCCGTCGGCATCC

>NC_014541|1|1|1653245-1653350|CRISPRCasFinder
CCCTGTGGGATCCCTCCTGTCGGCATCC	TTGTCTCTACCTCACCGAACTGCGATGCGTTGCATTGGTTCCGGTTCGCC
CCCTGTGGGATCCCTCCCGTCGGCATCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_014541.1\|WP_013344990.1\|1660510_1660996_+\|putative-4-hydroxy-4-methyl-2-oxoglutarate-aldolase	unknown	unknown	gnl\|CDD\|183553
NC_014541.1\|WP_013344986.1\|1657136_1657634_-\|DUF2878-domain-containing-protein	unknown	unknown	gnl\|CDD\|378555
NC_014541.1\|WP_013344983.1\|1654965_1656384_-\|aspartate-ammonia-lyase	unknown	unknown	gnl\|CDD\|237031
NC_014541.1\|WP_013344976.1\|1646957_1647719_-\|hydroxyacylglutathione-hydrolase	unknown	unknown	gnl\|CDD\|274569
NC_014541.1\|WP_148226716.1\|1656462_1656678_-\|hypothetical-protein	unknown	unknown	unknown
NC_014541.1\|WP_148226715.1\|1644239_1645205_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|341003
NC_014541.1\|WP_013344982.1\|1653540_1654815_+\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635
NC_014541.1\|WP_013344989.1\|1659437_1660382_-\|DUF1722-domain-containing-protein	unknown	unknown	gnl\|CDD\|377367
NC_014541.1\|WP_013344972.1\|1640577_1641600_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293838
NC_014541.1\|WP_171814256.1\|1649915_1651199_+\|TIGR03503-family-protein	unknown	unknown	gnl\|CDD\|274613
NC_014541.1\|WP_013344978.1\|1648632_1649103_-\|ribonuclease-HI	unknown	unknown	gnl\|CDD\|178927
NC_014541.1\|WP_013344987.1\|1657630_1658071_-\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|378915
NC_014541.1\|WP_013344991.1\|1661019_1662852_+\|AsmA-family-protein	unknown	unknown	gnl\|CDD\|236772
NC_014541.1\|WP_013344973.1\|1641690_1643949_-\|catalase/peroxidase-HPI	unknown	unknown	gnl\|CDD\|237891
NC_014541.1\|WP_013344988.1\|1658060_1659431_-\|deoxyribodipyrimidine-photo-lyase	unknown	unknown	gnl\|CDD\|236734
NC_014541.1\|WP_013344971.1\|1638649_1640563_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|184080
NC_014541.1\|WP_013344975.1\|1645307_1646873_-\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|182727
NC_014541.1\|WP_013344977.1\|1647849_1648623_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|369777
NC_014541.1\|WP_013344979.1\|1649185_1649908_+\|DNA-polymerase-III-subunit-epsilon	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|235574
NC_014541.1\|WP_013344985.1\|1656917_1657133_-\|TIGR02450-family-Trp-rich-protein	unknown	unknown	gnl\|CDD\|370527

Protein	Function_ID	Function_description	E-value
NC_014541.1\|WP_013344990.1\|1660510_1660996_+\|putative-4-hydroxy-4-methyl-2-oxoglutarate-aldolase	gnl\|CDD\|183553	PRK12487, PRK12487, putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase.	5.70521e-87
NC_014541.1\|WP_013344986.1\|1657136_1657634_-\|DUF2878-domain-containing-protein	gnl\|CDD\|378555	pfam11086, DUF2878, Protein of unknown function (DUF2878). This bacterial family of proteins has no known function. Some members annotate the proteins as the permease component of a Mn2+/Zn2+ transport system however this cannot be confirmed.	5.99929e-24
NC_014541.1\|WP_013344983.1\|1654965_1656384_-\|aspartate-ammonia-lyase	gnl\|CDD\|237031	PRK12273, aspA, aspartate ammonia-lyase; Provisional.	0
NC_014541.1\|WP_013344976.1\|1646957_1647719_-\|hydroxyacylglutathione-hydrolase	gnl\|CDD\|274569	TIGR03413, GSH_gloB, hydroxyacylglutathione hydrolase. Members of this protein family are hydroxyacylglutathione hydrolase, a detoxification enzyme known as glyoxalase II. It follows lactoylglutathione lyase, or glyoxalase I, and acts to remove the toxic metabolite methylglyoxal and related compounds. This protein belongs to the broader metallo-beta-lactamase family (pfam00753). [Cellular processes, Detoxification].	4.13202e-131
NC_014541.1\|WP_148226715.1\|1644239_1645205_+\|hypothetical-protein	gnl\|CDD\|341003	cd17445, MFS_SLC22A17, Solute carrier family 22, member 17 of the Major Facilitator Superfamily. Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	0.00944243
NC_014541.1\|WP_013344982.1\|1653540_1654815_+\|diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	2.46738e-47
NC_014541.1\|WP_013344989.1\|1659437_1660382_-\|DUF1722-domain-containing-protein	gnl\|CDD\|377367	pfam04463, DUF523, Protein of unknown function (DUF523). Family of uncharacterized bacterial proteins.	5.14165e-53
NC_014541.1\|WP_013344972.1\|1640577_1641600_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293838	cd16280, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily.Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	6.44951e-138
NC_014541.1\|WP_171814256.1\|1649915_1651199_+\|TIGR03503-family-protein	gnl\|CDD\|274613	TIGR03503, TIGR03503, TIGR03503 family protein. This set of conserved hypothetical protein has a phylogenetic range that closely matches that of TIGR03501, a putative C-terminal protein targeting signal.	1.82568e-112
NC_014541.1\|WP_013344978.1\|1648632_1649103_-\|ribonuclease-HI	gnl\|CDD\|178927	PRK00203, rnhA, ribonuclease H; Reviewed.	1.7519e-99
NC_014541.1\|WP_013344987.1\|1657630_1658071_-\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|378915	pfam12680, SnoaL_2, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	4.6805e-17
NC_014541.1\|WP_013344991.1\|1661019_1662852_+\|AsmA-family-protein	gnl\|CDD\|236772	PRK10833, PRK10833, putative assembly protein; Provisional.	1.62458e-52
NC_014541.1\|WP_013344973.1\|1641690_1643949_-\|catalase/peroxidase-HPI	gnl\|CDD\|237891	PRK15061, PRK15061, catalase/peroxidase.	0
NC_014541.1\|WP_013344988.1\|1658060_1659431_-\|deoxyribodipyrimidine-photo-lyase	gnl\|CDD\|236734	PRK10674, PRK10674, deoxyribodipyrimidine photolyase; Provisional.	5.72257e-159
NC_014541.1\|WP_013344971.1\|1638649_1640563_+\|TonB-dependent-receptor	gnl\|CDD\|184080	PRK13483, PRK13483, ligand-gated channel protein.	0
NC_014541.1\|WP_013344975.1\|1645307_1646873_-\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|182727	PRK10783, mltD, membrane-bound lytic murein transglycosylase D; Provisional.	5.04042e-137
NC_014541.1\|WP_013344977.1\|1647849_1648623_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	1.33527e-09
NC_014541.1\|WP_013344979.1\|1649185_1649908_+\|DNA-polymerase-III-subunit-epsilon	gnl\|CDD\|235574	PRK05711, PRK05711, DNA polymerase III subunit epsilon; Provisional.	1.39304e-124
NC_014541.1\|WP_013344985.1\|1656917_1657133_-\|TIGR02450-family-Trp-rich-protein	gnl\|CDD\|370527	pfam09493, DUF2389, Tryptophan-rich protein (DUF2389). Members of this family are small hypothetical proteins of 60 to 100 residues from Cyanobacteria and some Proteobacteria. Prochlorococcus marinus strains have two members, other species one only. Interestingly, of the eight most conserved residues, four are aromatic and three are invariant tryptophans. It appears all species that encode this protein can synthesize tryptophan de novo.	1.56758e-15

>NC_014541.1|WP_171814256.1|1649915_1651199_+|TIGR03503-family-protein
MSRLIRAFGLTGWLALFAFSAQAELTPQTTELLDNRFRIDHAIDQITILAQRAPGSAPVVVVKPDGSKWYAHRHPDSVTWNATQSSDLIRINNPTPGPWQLVGEVVDGSELRLMSEVALRHDPLPERVYRGERVKLTAELLGDDDRIVMRDFEAQLDWSMSIRSANRPGDENFGAGPFMIGAYHDGGKGLDEVPHDGIFTSNLDFNYPAGLYRYKMAVSNEVFHRELTGEIEILPQPVRIALVELPSGETNHSELTITLEPDVTPENLHLDLAIETPDQSRYQLSITPTEPVQQMPLPMVSAYGNYRIEGEAAGTRYDGVEFFLSLPELAFYVAPPPPPPLSAEEMAAIALREAQEREASARTRVIWTVGAVNILLLVVGAAILIVWRKRQRLYQELMAMPIEPQELTPDQVDLTQFSPDDGAGTQR
>NC_014541.1|WP_013344979.1|1649185_1649908_+|DNA-polymerase-III-subunit-epsilon
MTQAADLRQIVFDTETTGMNQGAGPHYLGHKLIEIGCVELINRKPTGRTYHVYIQPDRPVDEEAIQVHGITDEFLVGKPRFGEIAEEFFEFIRGAELIAHNANFDIGFIDYEFEMLGRFGKLEDHCSLVDTLQLAREKKNRGEIQGNLNLDALCRFYGIDNSHRTLHGALLDAEILADVFLYMTGGQVKMNFGSGDGDAGGIIRLPEDRRRTKVVLATADELDNHTKRMELVSDAIWLRH
>NC_014541.1|WP_013344978.1|1648632_1649103_-|ribonuclease-HI
MAEKKRVTLYTDGSCLGNPGPGGYGIVLIYKRHRKEVGYGYQHTTNNRMEMMAALQGLALLTEPCQVSLYTDSQYLRQGITQWIHGWKRNGWKTAAKEPVKNVDLWQALDAQVARHEIDWHWVKGHAGDPNNERCDELARTAAGGDKLLPDSGFKS
>NC_014541.1|WP_013344977.1|1647849_1648623_+|methyltransferase-domain-containing-protein
MLRPAYSESPIEPPPSWQALPYGDWLKEQVESGLDEWWPRIFGYHLLKLGPLADTLPTRLCPVPHQFGLAPQRGSVRAELTRLPLQNASIDAALVPFCLEFQQDPHALLRELDRVLISGGHLVLVGFSVLSPLAFGYLWPKHHHQFPWSGRLFTPGRVHDWLSLLGYRVLSHESLAHHTMLWSPEKFPTAQRWLADLAPGFGSVYLIVARKMEAPLTPARQRWHLRRPLVGQPVREAVGRESKPQVAARQRSDTTKG
>NC_014541.1|WP_013344976.1|1646957_1647719_-|hydroxyacylglutathione-hydrolase
MMITPIAALNDNYIWCLHRDNAAWVVDPGSADAVLAHLEQQQLQLRGILITHHHWDHTDGIETLRNAFAAIPVIGPDNPVIQGLTQRVQHGQQVELDGLGVTAEVIALPGHTLDHLGYCVDNAVFCGDTLFSGGCGRLFEGTAAQMHSSLSQLAALPADTRVFCTHEYTLANLAFASAVEPDNEALLEYRRWCEAQRAAGLPTLPSTIGQERAINPFLRVDTAAVKAALSQREGTESDSVARFAALRHWKDKF
>NC_014541.1|WP_013344975.1|1645307_1646873_-|LysM-peptidoglycan-binding-domain-containing-protein
MKKTLPALAIALMLTGCQSLNLASQPESNQPEQDAAKASPAPDAAVAAKPAEPALPPPPTDVWERIRSQMAMDVPDNARVERFRKWYLNNPNHLNIISQRAAPFMYLIVEEIEKRDLPIELALLPIVESSFDVFAYSHGAAAGIWQFTAPMGRHFGLEQNWWYDGRRDVYASTVAAMDMMEYLHDKLHNDWYYALAAYNTGEGRVFRAIRNNKKAGKPTDYFALNLPSETERYVPQLLALADVIKNADEYGIKLNPIPNEPALKLVDAGSQIDLSFAADLADMSVGELHKLNPGYNRWSTAPDGPHTLLLPVEKADGFIVALADTDSAKRVNWVRYTVKPGDSLGVIAQKYHTRVGVIQSVNKLDGNLIRVGQALLIPVAAKDPEDYEFSADQRLARQQSSKRADYKTEHTVRSGESLWTIARANNVTVAQLASWNGMAPSDTLRPGRKLVIWVNRVSETQTKSSVMRQITYTVRSGDSLARIGQRFNVTVKDLVRWNQLQGQKYLQPGQRLKLYVDVTRV
>NC_014541.1|WP_148226715.1|1644239_1645205_+|hypothetical-protein
MVVLFLVQWVPAEVWAAYPELAITQRFLCDVAPRILLLCLMLALVLHLLERSLYKHLQRGGAVRLPFSLSTGLFVVLFGCSKLLMLVQSRIDQFTRGQRLALLTIALSSAGGLSSLALSAVGYPLYQLLLANLLLTALMTLMMLPLMGGGRQDNLLLRPDNDTPFRTRCLAFLSGGSKLVVNMTLVISVMESLLQRYPLDSVSVNRLVWLPERFFTALGFSPEYTQALAYHWVVKNLVNRDMAMIGLAEEGWLFQMPTIEQFLVVTQFVSIVGVSTVLIIGLNIIAMFGRKGWPLFRLMPLAVVLSTLLPLVPVLLLTGWR
>NC_014541.1|WP_013344973.1|1641690_1643949_-|catalase/peroxidase-HPI
MRLLSCSVAVTATLLAGLSGSALGNADMAKSNQFWWPEQLDLTPLRQHQSGSSPLDDDFHYAEAFSQLDLAAVKQDIAKVMTTSVDWWPADYGHYGPFFIRMAWHSAGTYRVADGRGGAGGGQQRFEPLNSWPDNANLDKARRLLWPVKQKYGRSLSWADLMVLTGNVALESMGFATFGFAGGREDDWEADKVYWGPETQWLDDKRYSGDRQLENPLAAVQMGLIYVNPEGPNGNPDPLAAAGDIRETFGRMAMNDEETVALIAGGHTFGKAHGARSPEDCVGPEPAAAGIEEQGFGWTNKCGSGNGEDTITSGLEGAWSVTPTQWSSQYLDNLFAFEWVQTKSPAGAVQWIPDDPNAANLVPDAFDSNKRHAPIMFTTDLALKFDPAYREISMRFQKDPEAFQQAFAKAWFKLTHRDLGPRARYLGAEVPETILIWQDPIPKVEHDLISEANATALKQRVLESGLTVPMLVRTAWASASTFRGTDMRGGANGARLRLSPQKDWPVNRPEELAQVLATLEGIRSSFNEQNTETPISLADLIVLAGNAAVEKAAKDAGYELTVPFRPGRADASADQTDEISFAFLEPSADGFRNYYGDDARLPPTAALVDKASLLTLSAPEMSVLVAGMRSMDANSDGSRHGVLTDAPGTLSNDFFVNLLDMDTRWQKAGEALYEGVDRSSGKVKWTATPVDLVFGSNSELRALAEFYAADDAKAQFVEDFGRAWHKVMTLDRFDAPRIKTERNTTNLTVSTE
>NC_014541.1|WP_013344972.1|1640577_1641600_+|MBL-fold-metallo-hydrolase
MMMKMTRPWLLTPILAALTLAPAQAEPALNAQQMAERGLLHADTFSGMANICDLSKPLKVAGQRPKSGADGTSRPKREKRQRRDIAPTQVFDNLYYVGTGSVASWVLQTSEGLILIDALHNNGEAEAYIEAGLRTLGLDPNDIKILLVTHGHGDHYGGQEYLVKHYQPKVVMSEAEWRYLEQPVLPVTNPRWGKPPQRDVSVNDGDTLTLGDTTIALYVTPGHSDGTLSLVFPVQDNGTTHIASLWGGTGLNFGPIESQLMQYSENAERFRQIAITAGADVFLSNHPTRDVTAERLPMLAQREVGEAHPFVLGVERANQVYELLRDCSHAQALKIQESRR
>NC_014541.1|WP_013344971.1|1638649_1640563_+|TonB-dependent-receptor
MPAYKLSLAPISALSLWFTPVVAASEPPNETMVVTASGFEQDVTQAPATISVIGREQFENRAYQDITDVLKDVPGVVVTGGGSRQDISLRGMPAQYTAILVDGRKQSGRESQPNGSGGFEQDWLPPLDAIERIEVVRGPMSTLYGSDAIGGVINIITRKDYDQWQGNLRVEATLQENADSGNLYQGQLRASGPLIEGLLSASLYGTYQERKEDDIERGYSGKVLNNYRGSAYLTPSEQDTFTLEFAHQDQTRESTAGLSLPDRNDSSQTENRHQSWSLAHEGRYDSVMGQSYLQQESTENLGRDITITNFTANSQWTLPLDAHYLSLGVTWLRSELEDHSTNINGSQTEISNDQWSLFAEDEWLMLDNFALTVGVRVDDNEQFDLHVSPRIYGVWSLNHAWTLKGGVSTGYRAPELREMAPGWVQVSSGGDIYGNPELKPEVSLNKEISLLYAGERGLQSSVTLFHNDFEDKVTLVSCDAERCGGDPDARQNINIDEAVIYGAEAALAVDLLDNLSLSASYTFTESEQRSGEFEGRPLTQIPRHVFSTNLQWRPTETLGAWGRVNFRGEESQPVNDSRRAIVAPSYGVLDIGGDWQVTSRVKLMLGIYNLTDKAIDYDNYGYVADGRRYWLAVNTEF
>NC_014541.1|WP_013344982.1|1653540_1654815_+|diguanylate-cyclase
MKVRAKVTILFSFLLTAAIANTYFIFALDQQGEEKRRRVAHTHEVILESERLLGHLVDAETGQRGYLLTANAAYLAPYHRALSAISTKQNRLSFLTAKDPQQQALLRQIDRSIALQLQELKATIELNAAGEQTIAMKVMSLNQGKYFMDDIRRQMRRFASHEREQLALHQGEFNQYRVEIKTLIYAEFVFFICLALFTFFFLRNSLFSRLSVLLNSVEKIKDGKVVSQAELQSNDEISLLMDAFVDLSYRVNQRERVLEFKAHHDELTGLKNRLALREDLETALEQLKQDKLALLFIDVNGLKSLNDSKGHDYGDALLCETACRLQASVRDTDVVYRIGGDEFIVLLKHIKAVSDVDRVLSKMHRSFIKPMTYNGAIVPLSASVGIAIAPDDAATAEALITFSDSAMYHAKLSGNAGFRYHRPS
>NC_014541.1|WP_013344983.1|1654965_1656384_-|aspartate-ammonia-lyase
MNHNSAFRIEHDLLGDAQVPHTAYYGIQTQRAKENFNITGVAISHFPQLVNALAMVKMAAAKANLEVGVLSQHHHDAIVAACQEIIEGQWHDQFIVDLIQGGAGTSTNMNANEVIANRGLEILGYAKGNYAQLHPNNHVNLAQSTNDAYPTAVRLAVIFASQPLIDAITDLVEALQRKGDEFDDVLKMGRTQMQDAVPMTLGQEFRAFAHTLAEDIDRLREAAKLLAEVNLGGTAIGTGINAHPDYADAAIRHLTDIAKVEMKSASDKVEATVDMGAFVLYSGILRRIAVKLSKICNDLRLLSSGPRCGFNEINLPAMQPGSSIMPGKVNPVIPEAVNQTAFQVIGNDLAVTMAAEAGQLQLNAMEPLITYNLLNSTKMLSDAMAMLTTRCVVGITANKDHCQQLVNNSLALATLLNPYIGYENTTRLAKTALQTGQGIVELVLEEGLLTQEQLDRLLDPEVMLKPSIAQLG
>NC_014541.1|WP_148226716.1|1656462_1656678_-|hypothetical-protein
MRAFLNELAWSDKQLETFKEVIDEMLNERREAAKKQEQVQTYKAKLINLAKDLDMSYQELLVTMVDLDSRR
>NC_014541.1|WP_013344985.1|1656917_1657133_-|TIGR02450-family-Trp-rich-protein
MNVFSSKDLLLSKWTSNAHFHDETHFVVTGTLTDSQGEVTKVVLQGVHNGREFELARESLEDSDLWRMGWR
>NC_014541.1|WP_013344986.1|1657136_1657634_-|DUF2878-domain-containing-protein
MNRRLIAVLVLFDINWALAVFGQQDTLLWQALTTVAMVACARGWRLGGLAIAAIGMAFDGLLIQQQVLSLTGSPVAMPIHLALLWVGFGLTLAACHQRLPRSPWALALVGGVIGALGYFLGVQFGALQLAPTTALGVIIIGVGWAALFPLCRALFTTVSPIAHGR
>NC_014541.1|WP_013344987.1|1657630_1658071_-|nuclear-transport-factor-2-family-protein
MLHRIPEGPVEAFARVWQTLGRDHLDQVDTLYHPDVVFADPSGELHGRDRFKAHLATLYQNVDECHFELGVPIGTPPHWAQPWVMTLRHPKLAGGKPVRVEGISELRCQEGLITHHRDYFDMGQMLYEQVPVLGPATRWLKARMSP
>NC_014541.1|WP_013344988.1|1658060_1659431_-|deoxyribodipyrimidine-photo-lyase
MQLVWFRDDLRVHDHPALFAAAQRGEPVVALYIASPQQWQLHDCGPRKAQWHYANVQALREALAGLGIPLTVWRCEHFDDIPARLGALCNEAGIGAVHCHHGLGVNERALEQKLADQLPVPLHRYADANLVDYSAITTGQGGLYQVFTPFARRCRQWMAPPQPLPAPEPQAAQPPLQADDAWSETVDLLWPAGEQAAARTLARFCQQRLSAYHDDRDWPAKAGTSALSPYFAAGVLSPRQAAHALSQQADGEGAQSWLNELLWREFYRYLLYHHARLSRHDALFPAKEARWEANDEWLRRWQQGRTGFPLVDAGMRQLNATGWMHNRVRMLCASFLVKDLHIDWRLGEAYFMQQLVDGDLASNNGGWQWAAGCGADAAPYFRSFSPYRQSERFDPDGDYIRQWVPELAEVPARQLHKGGPFLLAPDYPAPMVDHKAQTARFTAQFKQQMEETRHAS
>NC_014541.1|WP_013344989.1|1659437_1660382_-|DUF1722-domain-containing-protein
MTMPKVGVSACIVGQEVRFDGGHKRSGFVDGPLKNIFDMKPLCPEMGMGLGTPRPTIRLREIGESVRLMDDKNHIDHTDAMQAFNERTLPNLAGLSGYIVCAKSPSCGMERVRVMNEQQNGARHNGRGLFTAALMEAYPLLPVEEDGRLNDIPLRENFITRVFVYHAYQELVASEPGEHQLLAFHRRHKLLLMAHNQATYRELGRYIAISRERPMAERLAYYGERMMHALAKPASRRNHTNVLQHIGGYFKRELDTTERQHLHETILAYHDGQLPLMAPITLLQSLLKRYPKPYIEEQHYLQPHPQHLALRYHL
>NC_014541.1|WP_013344990.1|1660510_1660996_+|putative-4-hydroxy-4-methyl-2-oxoglutarate-aldolase
MLDLLPDLCDAHPDVVRLFPPIFRQFGGKRIFHGPVVTLRCPEDNSLVREAVAEPGQGRVLLIDGGGLARRALLGDMLAEKAVANGWSGIVVFGYVRDVATLATLDLGVQALGAVPMKTEKRGLGDRDVVVEIDGIRIQPGDYLYADDNGVLVAPHALPLP
>NC_014541.1|WP_013344991.1|1661019_1662852_+|AsmA-family-protein
MKVIKWLLLGLLTVVVVLTLYLAFFFDLNSFKGPIADKVKQATGRELVIGGDIGWSVYPTLGLELAQVQLGNLPGEQLPPLLSVEQASVGVALLPLLKRELQVEELAVSGVHLELVTLADGRSSLTGLGGEGAAKPSEAAPATDSSAAAPKRWVLGHLAVNDLTIHNDNRAAGADQTLAIKQLELARIEPERAAPLRLQVEVGDGDLAVSTQAEAMLTVSADFSRFQIDDWRQQLEAKGSAIGAQPLALSLAWDADLNLAEQQFVVTNLEFKLADFILNGEAQANLAGVRPAFQLTAKGNALNLDPWLPADIADKGTDKSEPAPESAPAPQEEPDLSAMKLLDLDADLHLGALKARGIEAEDLALKLRLNAGVLTLENASGKAFGGQLTAKASLDGTATPARYSFDQRIEHLSIQPMLKALADTDLLAGTGEFSLKGKGQGLTGKALNNLTATGALALEDGAVYGVNVAQMIREAEAKLKGDFKAEVAEQKTDFSNFHTQLVIEDGTLGTPGLKIASPLLRIEGDGKVAIEPQTLDYQLVVALVGSLEGQGGKGLDELKEIPIPLSISGPITNLSYGLDTDALLKGKLDQEKDKLEEKLKDKLFERLGNF

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Crispr_ID: NC_014541_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014541_2

2116966-2117073

Orphan

Consensus_repeat	Method
GCGATGGCCTGAGGGTTATGAAGACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014541_2

>merge|NC_014541|2|2116966-2117073|CRISPRCasFinder
GCGATGGCCTGAGGGTTATGAAGACCGATTCAGGTCATCTTGAAAGTGATTGCGGGGGCCGGATTTAACGGGCTGTCCCACAGCGACGGCCTGAGGGTTATGAAGACC

>NC_014541|2|2|2116966-2117073|CRISPRCasFinder
GCGATGGCCTGAGGGTTATGAAGACC	GATTCAGGTCATCTTGAAAGTGATTGCGGGGGCCGGATTTAACGGGCTGTCCCACA
GCGACGGCCTGAGGGTTATGAAGACC

Protein	Signature genes	Signature genes Name	Protein_function
NC_014541.1\|WP_013345388.1\|2099049_2101155_+\|DUF1302-domain-containing-protein	unknown	unknown	gnl\|CDD\|377751
NC_014541.1\|WP_013345390.1\|2102587_2103601_+\|glycosyl-hydrolase	unknown	unknown	gnl\|CDD\|226855
NC_014541.1\|WP_013345395.1\|2113102_2114299_+\|patatin-like-phospholipase-family-protein	unknown	unknown	gnl\|CDD\|132847
NC_014541.1\|WP_013345389.1\|2101171_2102536_+\|DUF1329-domain-containing-protein	unknown	unknown	gnl\|CDD\|377764
NC_014541.1\|WP_013345391.1\|2103612_2106003_+\|RND-family-transporter	unknown	unknown	gnl\|CDD\|223964
NC_014541.1\|WP_013345401.1\|2122787_2124836_+\|DUF3466-family-protein	unknown	unknown	gnl\|CDD\|378770
NC_014541.1\|WP_013345399.1\|2120622_2120859_+\|glutaredoxin-family-protein	unknown	unknown	gnl\|CDD\|368604
NC_014541.1\|WP_013345392.1\|2106344_2111186_+\|NAD-glutamate-dehydrogenase	unknown	unknown	gnl\|CDD\|377452
NC_014541.1\|WP_013345405.1\|2126547_2128296_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|223994
NC_014541.1\|WP_013345398.1\|2118530_2120633_+\|bifunctional-23S-rRNA-(guanine(2069)-N(7))-methyltransferase-RlmK/23S-rRNA-(guanine(2445)-N(2))-methyltransferase-RlmL	unknown	unknown	gnl\|CDD\|236981
NC_014541.1\|WP_013345402.1\|2125182_2125359_+\|ribosome-modulation-factor	unknown	unknown	gnl\|CDD\|377425
NC_014541.1\|WP_013345396.1\|2114575_2115718_+\|HlyD-family-secretion-protein	unknown	unknown	gnl\|CDD\|224482
NC_014541.1\|WP_013345394.1\|2112459_2112999_+\|cell-division-protein-ZapC	unknown	unknown	gnl\|CDD\|369220
NC_014541.1\|WP_013345397.1\|2115707_2116718_+\|DUF2955-domain-containing-protein	unknown	unknown	gnl\|CDD\|371403
NC_014541.1\|WP_013345393.1\|2111246_2112272_+\|quinone-dependent-dihydroorotate-dehydrogenase	unknown	unknown	gnl\|CDD\|235388
NC_014541.1\|WP_013345404.1\|2125937_2126477_-\|bifunctional-3-hydroxydecanoyl-ACP-dehydratase/trans-2-decenoyl-ACP-isomerase	unknown	unknown	gnl\|CDD\|179953
NC_014541.1\|WP_171814260.1\|2129759_2130581_-\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|271180
NC_014541.1\|WP_013345400.1\|2120855_2122778_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|236861
NC_014541.1\|WP_013345406.1\|2128464_2129763_+\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271175
NC_014541.1\|WP_013345403.1\|2125443_2125926_+\|glutathione-peroxidase	unknown	unknown	gnl\|CDD\|238207

Protein	Function_ID	Function_description	E-value
NC_014541.1\|WP_013345388.1\|2099049_2101155_+\|DUF1302-domain-containing-protein	gnl\|CDD\|377751	pfam06980, DUF1302, Protein of unknown function (DUF1302). This family contains a number of hypothetical bacterial proteins of unknown function that are approximately 600 residues long. Most family members seem to be from Pseudomonas.	0
NC_014541.1\|WP_013345390.1\|2102587_2103601_+\|glycosyl-hydrolase	gnl\|CDD\|226855	COG4447, COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only].	3.16308e-31
NC_014541.1\|WP_013345395.1\|2113102_2114299_+\|patatin-like-phospholipase-family-protein	gnl\|CDD\|132847	cd07208, Pat_hypo_Ecoli_yjju_like, Hypothetical patatin similar to yjju protein of Escherichia coli. Patatin-like phospholipase similar to yjju protein of Escherichia coli. This family predominantly consists of bacterial patatin glycoproteins, and some representatives from eukaryotes and archaea. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of a lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have also been found in vertebrates.	5.95363e-28
NC_014541.1\|WP_013345389.1\|2101171_2102536_+\|DUF1329-domain-containing-protein	gnl\|CDD\|377764	pfam07044, DUF1329, Protein of unknown function (DUF1329). This family consists of several hypothetical bacterial proteins of around 475 residues in length. The majority of family members are from Pseudomonas species but the family also contains sequences from Shewanella oneidensis and Thauera aromatica.	0
NC_014541.1\|WP_013345391.1\|2103612_2106003_+\|RND-family-transporter	gnl\|CDD\|223964	COG1033, COG1033, Predicted exporters of the RND superfamily [General function prediction only].	1.00248e-102
NC_014541.1\|WP_013345401.1\|2122787_2124836_+\|DUF3466-family-protein	gnl\|CDD\|378770	pfam11949, DUF3466, Protein of unknown function (DUF3466). This family of proteins are functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 564 to 612 amino acids in length.	3.31262e-179
NC_014541.1\|WP_013345399.1\|2120622_2120859_+\|glutaredoxin-family-protein	gnl\|CDD\|368604	pfam05768, DUF836, Glutaredoxin-like domain (DUF836). These proteins are related to the pfam00462 family.	6.69571e-12
NC_014541.1\|WP_013345392.1\|2106344_2111186_+\|NAD-glutamate-dehydrogenase	gnl\|CDD\|377452	pfam05088, Bac_GDH, Bacterial NAD-glutamate dehydrogenase. This family consists of several bacterial proteins which are closely related to NAD-glutamate dehydrogenase found in Streptomyces clavuligerus. Glutamate dehydrogenases (GDHs) are a broadly distributed group of enzymes that catalyze the reversible oxidative deamination of glutamate to ketoglutarate and ammonia.	0
NC_014541.1\|WP_013345405.1\|2126547_2128296_-\|AAA-family-ATPase	gnl\|CDD\|223994	COG1067, LonB, Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones].	5.11938e-117
NC_014541.1\|WP_013345398.1\|2118530_2120633_+\|bifunctional-23S-rRNA-(guanine(2069)-N(7))-methyltransferase-RlmK/23S-rRNA-(guanine(2445)-N(2))-methyltransferase-RlmL	gnl\|CDD\|236981	PRK11783, rlmL, bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2))-methyltransferase RlmL.	0
NC_014541.1\|WP_013345402.1\|2125182_2125359_+\|ribosome-modulation-factor	gnl\|CDD\|377425	pfam04957, RMF, Ribosome modulation factor. This protein associates with 70s ribosomes and converts them to a dimeric form (100S ribosomes) which appear during the transition from the exponential growth phase to the stationary phase of Escherichia coli cells.	2.50072e-26
NC_014541.1\|WP_013345396.1\|2114575_2115718_+\|HlyD-family-secretion-protein	gnl\|CDD\|224482	COG1566, EmrA, Multidrug resistance efflux pump [Defense mechanisms].	9.29431e-67
NC_014541.1\|WP_013345394.1\|2112459_2112999_+\|cell-division-protein-ZapC	gnl\|CDD\|369220	pfam07126, ZapC, Cell-division protein ZapC. ZapC is one of four FtsZ-binding components of the Z ring in bacteria. Formation of the Z ring on the cytoplasmic surface of the membrane is the starting process for assembly of the cell-division apparatus. It binds directly to the Z ring, and although it is not essential for absolute cell division it contributes to it by enhancing the interactions between the FtsZ protofilaments (or polymers) which aggregate to form the ring conformation in the Z ring.	1.28554e-79
NC_014541.1\|WP_013345397.1\|2115707_2116718_+\|DUF2955-domain-containing-protein	gnl\|CDD\|371403	pfam11168, DUF2955, Protein of unknown function (DUF2955). Some members in this family of proteins with unknown function annotate the proteins as membrane protein. However, this cannot be confirmed.	5.43953e-16
NC_014541.1\|WP_013345393.1\|2111246_2112272_+\|quinone-dependent-dihydroorotate-dehydrogenase	gnl\|CDD\|235388	PRK05286, PRK05286, quinone-dependent dihydroorotate dehydrogenase.	0
NC_014541.1\|WP_013345404.1\|2125937_2126477_-\|bifunctional-3-hydroxydecanoyl-ACP-dehydratase/trans-2-decenoyl-ACP-isomerase	gnl\|CDD\|179953	PRK05174, PRK05174, bifunctional 3-hydroxydecanoyl-ACP dehydratase/trans-2-decenoyl-ACP isomerase.	8.30756e-119
NC_014541.1\|WP_171814260.1\|2129759_2130581_-\|tyrosine-type-recombinase/integrase	gnl\|CDD\|271180	cd00799, INT_Cre_C, C-terminal catalytic domain of Cre recombinase (also called integrase). Cre-like recombinases are tyrosine based site specific recombinases. They belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre recombinase maintains the circular phage replicon in a monomeric state by catalyzing a site-specific recombination between two loxP sites. The catalytic core domain of Cre recombinase is linked to a more divergent helical N-terminal domain, which interacts primarily with the DNA major groove proximal to the crossover region.	2.75246e-40
NC_014541.1\|WP_013345400.1\|2120855_2122778_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|236861	PRK11147, PRK11147, ABC transporter ATPase component; Reviewed.	0
NC_014541.1\|WP_013345406.1\|2128464_2129763_+\|site-specific-integrase	gnl\|CDD\|271175	cd00397, DNA_BRE_C, DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine based site-specific recombinases (integrases) that share the same fold in their catalytic domain containing conserved active site residues. The best-studied members of this diverse superfamily include Human topoisomerase I, the bacteriophage lambda integrase, the bacteriophage P1 Cre recombinase, the yeast Flp recombinase, and the bacterial XerD/C recombinases. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. The enzymes differ in that topoisomerases cleave and then rejoin the same 5' and 3' termini, whereas a site-specific recombinase transfers a 5' hydroxyl generated by recombinase cleavage to a new 3' phosphate partner located in a different duplex region. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.	3.69176e-13
NC_014541.1\|WP_013345403.1\|2125443_2125926_+\|glutathione-peroxidase	gnl\|CDD\|238207	cd00340, GSH_Peroxidase, Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per subunit, which is involved in catalysis. Different isoenzymes are known in mammals,which are involved in protection against reactive oxygen species, redox regulation of many metabolic processes, peroxinitrite scavenging, and modulation of inflammatory processes.	2.15315e-92

>NC_014541.1|WP_013345397.1|2115707_2116718_+|DUF2955-domain-containing-protein
MFHSRANGLIRLAVFPVLLLFLQYQFGTRLPLIAPALAAVFLSVSAVAPPVIMVVMMASVLAATAWVQAQISILLIDHPLVYYIMLFVLVYWCMQRIRDNPADLLGILMLVSTAIVAVFTQQKGAEVSQLSLSLLLEMGYAGLTAYLAYFLFPGGDPIAETPKAPPSQALHTEIWHLVVKAAVVILVLWAVIRMDLAQSTIVAITVANIIKDPNPIVGKQYGWFRVATTYGGFLFALPVLLMSLLQTNFIGQLGAALVCAMLMGIYAIKRQASFNTLQLLYTGFIVLVYYGLTETAGTALLADGKRLLSILGAVVLGMLVLIVLQPKTTTELESRT
>NC_014541.1|WP_013345396.1|2114575_2115718_+|HlyD-family-secretion-protein
MNDSVSGPSTNATSNESAPSEPQDSGKTLNSARRFTFILLFAALTIWLYTLWVDRLTPMTDHVRVNGQLIRLSPQVSAQIEKVLVPDNARVSQGEPLIQLEKHQFQLKVDSAKAALQQTTQSVDADTAAVAVAKANQVAARVRLDNSRQHAERNVALAENGVISQSALDDSLADVQSAEAQLAQATANLEKAKQALGPIGENNPQLKSALNQLDQALLNLSYTTLYAPGDGVITNMELATGDYAAAGKPLLTYINNDSLWLTAMVREISLAYVKPGTPVKIILDSYPGRSFEGEVQSIGWGSAGNGSLEVDANSGLMTSPNGLQHAQRFPVNIRFLELPDDVQLRYGGRATVSFYPGQTETGEKLLDLWTWIWSYLSYVS
>NC_014541.1|WP_013345395.1|2113102_2114299_+|patatin-like-phospholipase-family-protein
MSTRTLFPLLIALSLCGCSSVERQPVPESMSESVTVLGRDDLREWGDEIGITPTDILKKYGELETVFPAIMHREHHYLVLSGGAEDGAYGAGVLAGWSEAGTRPEFTMVTGISTGALIAPFAFLGSEYDPVLEAIYTTLGSKDLYTQRSWLSLFTADAVGDTTPFKASIARFLDDRTLDAIAAEYLRGRQLLIGTTNLDAGRPVIWNVTRIAASGHPGAYPFIRSLFLASAALPGLFPPVYVPVEGPQGQPMDEMHVDGGVTAQLFFAPSNIDWSEVIRLLDVKGTPTLYLIRNSRVESRYQTVDPNLKAIAGRTIGTLIRTQGVGDIYRLLYLSERDHIRIKSTWIPVDAVVDVSIDEVFDTDYMKALYQYGRERALSDRLWFIKGASINDGEDDEP
>NC_014541.1|WP_013345394.1|2112459_2112999_+|cell-division-protein-ZapC
MYITPEPCWAWMYHHDEDKLALELGEDWLFLSPFSARHLIPDSLHGAAFSAQHADYYNDVLDRLRKQLPNSAPEVVQIALNLTAAHFFSLPMMPKSWFFQTSAHIAYACNGKLVELDTGSERARFAVVDGGEQSSLLMLLEQSLALGNKKTMKQFELIKVMNDRLSPCQSLKHRRIVAA
>NC_014541.1|WP_013345393.1|2111246_2112272_+|quinone-dependent-dihydroorotate-dehydrogenase
MFYRIAQKFLFQTNPEFAHDFAMGSLRRTANTPLACFYAQNVPHAPVEFMGVQFPNPVGLAAGMDKDGEAIDAFAAMGFGHVEVGTVTPRPQPGNDLPRLYRLKPARAIINRMGFNNKGVDNLVANIKASNPGNCVIGVNIGKNKDTPLEEGKNDYLICMEKVYDVAGYIAVNISSPNTPGLRTLQYGEMLDDLLASLKTKQRELAEKYGKYVPVALKIAPDLSDEEIRQVAASLVRHEIDGVIATNTTLAREGVEHLPEHTEAGGLSGAPLTERSTIVIRKLADALDGKLPILGVGGIDSAQHAMDKLDAGAKMVQIYTGFIYNGPELVKTITEAFLKRK
>NC_014541.1|WP_013345392.1|2106344_2111186_+|NAD-glutamate-dehydrogenase
MAMQPSTPQVLLDNVVELIHKKMPEQQAPLIDAFARLIFGTLAKDELSQRSDSDLYGATLSLWNTLNQTQAGEFRNRVYNPVQSTHGWQSAHTIIEMVLPDMPFLVDSVSMALNRSGIASHLMIHSPVAITRDDKGAVNGVRHVLEGQADDERVAVFLVEVDNIDDAKRMTALARELDSVILDVTAAVNDWQPMQDKLAEVTNMVKTGPHAGHESDREEAVAFLEFLANHHFTFLGYRHYDLTRVEGDINLQGDNDSSLGIMREQPSQGLLLSSLPEQARKEALGSGRLILTKTNTKSRVHRPAYIDYVGVKCFDENGQVVGEHRFIGLYASSMYNRSPREIPLIRRKLEQVVSRSGLAPNSHDYKALMNILETYPRDELIQASEQQLFEGAMGILHMQDRDKVRLFVRRDPFGRFFSALVFTTKERYNTQLRIKTQKLLAECFQSEDEVEFTTYFSESTLARTHYLVKVEDNNMDIDVKELENNLVELARSWEDKLDSALVESRGEAQGKQLSRRFVNAFPRSYKEDVLPSAALVDIEHLEKLETSDELGMLFYQPQEKKLGGKQVCLKLFHKNEPIHLSDVLPMLENFGLRVIGERPYQVVTSEGNEYWILDFSMTFKGEVEEDISSYQARFQEALGKVWAAEYEDDGFNHLVLSAGLTGREVTVLRAYAKYMRQIGVTFSQEYIAETLDKYPHIARLLVDMFAKRFNPKSRANRTLDKQLAQVEAYLDDVANLDDDRIIRRYVELIEATLRTNFYQPVSSGEDKPYVSFKVLPELIPEMPLPLPKFEIFVYSPRMEGVHLRGGKVARGGLRWSDRREDFRTEVLGLVKAQQVKNTVIVPSGAKGGFVCKQLPAERDAMLAEGQDCYRMFIRGLLDVTDNIEQGELVPPLNVVRHDEDDPYLVVAADKGTATFSDIANSISEEYNFWLGDAFASGGQYGYDHKKMGITARGGWESVKRHFREMGVDCQTTDFTCLAIGDMAGDVFGNGMLLSRHTRLQAAFNHMHIFIDPTPDAATSYEERERLFKLPRSSWEDYNAELISEGGGIFNRSAKSIKLTPQMKTMLATKKVQMTPNELIQHLLQMEVDLLWNGGIGTYVKGARETHVEVGDRANDAVRINGSQLKAKIVGEGGNLGLTQLGRIEYAQAGGRINTDFVDNVGGVDCSDNEVNIKILLNRLVAEGEMTVKQRNKLLVEMTDEVAEIVLEDCRNQTLSISVTQARNGEQLKEQIRFIQYLEKEGKLDRALEFLPSDEELSERLAAGHGLTRPELSVLVAYAKMVLKEQLVDPSVTDEPTISQRLFEYFPVRLQAKYSEWMKEHPLRAEIIATSLANDIINNMGLNFIQRMQDETGASVSEVALSYTIAAQVFGLDSIKAQIIEQNGVVDAERQHEMLYQLQRTVRRATRWFLRRRTGNLDVEASVAFFQPVVQELNQSFGSLLQEEEARGIEARAESLVASGVNAELAHTVSRLSTLFSALDLAEIAKDDNKPVSLVAETYFRLGAGIELHWFLEQINEQPVSNHWQALARAGFREELDWLQRRLTLVVLRNCGAQCQADAIIEQWVDDNNATLDRWLHMMAEFRTSKSHEFSKFSVALRELNLLIMRCDSIAEAR
>NC_014541.1|WP_013345391.1|2103612_2106003_+|RND-family-transporter
MLDKWINTIELMVFRHRAAVLILFTLMSAFLGYSATELKMDAAFTKNIPLNHPYMQTYMKHREQFGGANSIMVAVSDKSGDIYNPKFFEVLRQIHDQLFFIPGVDRTQVKSLYSPSTRFTEVVEDGFRGGPVIPADFSADPAGLAQVKDNVEKAGIVGRLVSDDFSAAMVTAQLLDWVPIPEEERVEGGPVTRSMDVLAFAEQLEAEIRQQYEDDQIQVHIIGFAKMSGDVADGAKDVLLFFLIAILITAVMVFYFSRSVMMTLLPLGCSLIAVVWQMGGLTVLGFGLDPMSILVPFLVFAIGVSHGVQMINAVGHRVAEGSTAKAAAQSAFRSLLVPGGVALLSDTVGFLTLLAIDIGIIRELAITASLGVGLIILTNLVLLPVLLSYVKFSPAYLDKIRASHGKVAPIWHTVSRFAEGRRAKVVVGAALVLFGLGYFQAQTMKIGDLHAGAPALKEESRYNQDTFYITDNFSITTDVLTVIVEAYPEACTYHEVMERIDRFQWRVENVAGVQSTASLASIAKIVNGGYNEGNPKWRTLPRTTATLVQATSRVPTSSGLLNGNCSVMPVYLFLQDHKAETLDRVVAAVKAEAERFNTPEVQFKLASGPAGVMAATNEAVAEAQTPMMIYVYGAVFLLCLLSFKSLRATLAVILPLYLVSTLAQALMTFLQIGLTVSTLPVIALGVGIGVDYGIYILSTMTPYLRAGMAVQDAYLKALCERGNAVVFTGITLAVGVSTWVFSSLKFQMDMGILLTFMFLVNMVAAVVVLPALVRLLWGKGHPVSQQAPSTDTRQAA
>NC_014541.1|WP_013345390.1|2102587_2103601_+|glycosyl-hydrolase
MLYRILFSTALLSTSVLAAQADNPHAAYLAPKAAQAPLLDIERRGDGWLLVGDRGTVLQGDGQKWQQAASPLSVMLTSVTFADEQRGWAVGHDVTVLATSDGGQSWQIQQNLPNKDKPLLDVLALDGNEAIAVGAYGLFYRSTDGGRSWREEFHDELLFEEDREYLNELKAEDEALYLDERSAILPHFNRIKRLANGDLFLLGEMGFMARSSDNGHHWEKLEEIYFGSFMDLVELAPGHLLAVGLRGNAFRTDNGGLDWRPVETGIQSTINSGIALEDGRVVLVANGGVLLSSDDQGQSFTSKVLLKGEDLVAVAPAGEGSLLIVGSNGANLYPLAE
>NC_014541.1|WP_013345389.1|2101171_2102536_+|DUF1329-domain-containing-protein
MKKITVMASAMALMFGSGLAMAKVSPEEAAKLGKELTPMGAEMAGNADGSIPAWTGGITTPPAGYQPGTFHLDPYAGDAKIATITKDNMAEYAPFLSAGVQKMFEMYPDTFKMNLYPTHRSGSYPQFIYDATIKNATSAELVDGGNGIRGAATGVPFPIPANGLEVIWNHILRYRGETAEIQRNQAAPTAGGSYTLVETNEQIKFLYTIPGADAATLAKDNLLFYFKQVVTAPARLAGTALLVHETMDQSKQPRQAWTYNTGQRRVRRAPNVAFDTPGTASDGMRTTDDFDLYNGSPERYNWELVGKQEMYIPYNDYKLHSGDVKYDQILQAGHINMDLVRWEKHRVWVVEATLKDGVRHLYKTRRFYIDEDSWQIALVDLYDNRDEMYRVGMAHTVNYYEQPLVWTTLEVFYDLNSRRYMAMGLDNEGKVANFDADISAKDFTPQALRRQGRR
>NC_014541.1|WP_013345388.1|2099049_2101155_+|DUF1302-domain-containing-protein
MTASVSRFRRSVLAASIGLVLATPAQAVTFEWGDIQGSFDSTWTLGAAWRVEERDLDKIGKSNRFQWSPGYGFDFANGAFNDGGLESSQIFGLPGSYSSNGDLANMLYDKGDTFSEIFKGLHELELVYENVGIFVRGFYFYDNKLENGSFDYRNPLTGEEFDVCADDKASEYACSDIRLLDAYFFADFDLGEMPFSIRIGEQVVSWGESTLIAHGINSINPVDLARLQAPGSELKEAFIPVGTVWASLGLTENFNIEAYYQYRWEETRLPVTGTYFSSNDFAGAGGYVNNAQLGFTSNPDITLDHLLNEYQLLAQASAGAIAQSGATTPEELQAALAPLAPFAVPYGTKTTLVGYEQEPDDQGQFGVKLGYFAPSLNDTEFGLYYINYHSKRPLISGQAADFSGAALIEDLATLSAIAGAGGEVSRDDLLGLNAFSKAVIEYPEDIKLYGFSFNTTLGDTSVAGEIAYRQDEPLQIDDVELLYAAMPEQLYNADNDAYDVFEDLSQYRKPNGERLMPGEFGSGYVLTDSTQAQMTFTHIFGPTFGASNFLMLAEVGGVWLHDMPDPSVLRMNGPGTERAGLAGREDNAGVLNLLHNGPEEDAFPTDSSWGYRIVAKADYTNAMFGWNLSPRVVFSHDVSGTTPDPLFLFIEDRKSASLTLSGDYQNRWSFDVSYNAFWDGKGSTNSLEDKDFVSFNVKFSI
>NC_014541.1|WP_013345398.1|2118530_2120633_+|bifunctional-23S-rRNA-(guanine(2069)-N(7))-methyltransferase-RlmK/23S-rRNA-(guanine(2445)-N(2))-methyltransferase-RlmL
MKRFYAATPKGLEYLLVDELTELGAVNAKEGQAVVHFEAELDAAYRICLWSRLASRIVLVLDEVQAKTAEQIYDGVKGIFWPGVFAPQNDFAVDFHGGNREIRNSQFGALKVKDAIVDSFMEEWGTRPTVSKQSPQIRIDCALRADKLLVGLNLTGAAMHQRGYRLDKGKAPMRENLAAAVLMRSGWTQAMDKPLIDPFCGSGTLLVEAALMATDTAPLLQRQSWGFDHWAGHQPALWREVLTEAQVRANRGQNHCKTRFIGRDINRRVLSIAKENAERAGVASLIQFEGGDATNMPSPPATQGYVVANPPYGERLGDMPALLHLFARLGQQFKAEWAGWQVSLLCSDPMLLSALRLKAEKQYKLYNGALEVILANYPITEGVGGRVFGEDFANRLKKNLKGLAKWVKQQDIDCYRVYDADLPEYNVAIDRYQDWVVVQEYAPPKSVPEQKARQRLIDVLLHLPEVLEVDPQQVIVKVRQQQKGKGQYEKLAQEHEELKVNEYGAKFLVNLTDYLDTGLFLDHRLARRYIQEHAQDKRFLNLFAYTGSASVHAAVGGARATTTVDMSKTYLRWAEDNFSLNRLRGREHRFIQADCLAWLEACPEQFDFIFIDPPTFSNSKRMEKTFDVQRDHLWLMTQLKRILAPGGEILFSNNKRHFKMDEEGIRELGLVAKNITAQTQSPDFARNKQIHNAWVLHHAE
>NC_014541.1|WP_013345399.1|2120622_2120859_+|glutaredoxin-family-protein
MPNNTVVLFHTDGCHLCEQAEALLLEGGIAHSKADIVDKPEWVEAYGIRIPVVRRQDGAELGWPFDLAQLTQFVEDDE
>NC_014541.1|WP_013345400.1|2120855_2122778_+|ABC-transporter-ATP-binding-protein
MSLIRLNQAQLAFGHIPLLDHADFVLEPNERVCLVGRNGAGKSSLLKVLAGLQELDDGQLGLNTDITIAYLPQDPPRAESGTVFQYVAEGLAQLGKVIEEFELANQKVMADPSEKNLARLARAQEAMDHHNGWQFETRIHQTLSHLELDGQQPMTALSGGWQRRAALARALVQAPDVLLLDEPTNHLDIDAIEWLETLLLGFSGSIVFISHDRGFIRRMATRIIDLDRGQILSFPGDYQTYLDGKEEALRVEEEQAALFDKKLAKEEAWIRQGIKARRTRNEGRVRALKAMRNERAARINRLGKANMSMNQGERSGKLVFDVENLGYAWADSPIVKGLTTSVMRGDRIALIGPNGCGKSTLIKLLLEKLPAQQGTVKQGTNLQVAYFDQHRLELDPAKTVQENVGEGKDTVTVGGRDRHVLGYLQDFLFAPARARSPVSSLSGGEKNRLLLAKLFLKPANLLVMDEPTNDLDVETLELLEAKLAEFDGTLLLVSHDREFIDNTVTTTWWFNGDGQWDEFVGGYQDAVALGAKFYRPEAQTQEAVEAPSEPVSSKPASAPSSAAPKKLTYKLQRELDALPAKLETLEAEIESLQAQIAEPGFFDGDSQAVNAVLTRLAEKEQELEQDFARWEELEAMQGQA
>NC_014541.1|WP_013345401.1|2122787_2124836_+|DUF3466-family-protein
MSPTLFATRKVAVAVSAAMALGATSVQAEANWPAYEIQNINEVFSIRGTLDNSRNGYGAAFAGETALGIAKGVNDATTSEDDNVIDDVVDAILPEESATTNSIYRPFNGNNFLFEQSAATNWEPAYVPLLENTPPVLNPDEDENPDAIPRTNAFYFDATPLGLRTGSTSALQATPLPNENCDPAENSDCSEFLYYRDFESRAFVQSDAGYLLLPPEAASMAYVTADEDLDPTPVQTGGSSVATAVNDNGVVVGYASTEFSETAGDNIDLCIEALADEDSETVPLPIEACVQNLQNGSVIGYQTRGYVWQVDTSSMSIVSQQPLPLTFTPSELPTESDRDNVYLGQALGLSDGNNDFIVGRGNQLSKSDRPLSTLYAQAWKANGGDYSTYLIGPTVEDSERVEQSIAYDVNDSGLAVGVVRRWIDGYVRNKFAVVDLSAEPEEYRDGQRYMFTEPNDFFDSQSDLASIGRSINNNGIVVGNIEVDRVKNLPRRVRAFAYDHTNEDFINLNELLTCDSRGYVPAQEGDEGVEIDEAGNLWKSYTVVDDENFSTTITYNVEITLVDANQIDDNGNIVATALVRLPRVKTEEVEETDEDGNTTIRTVVVIDEATGKPVIETDANGNPTTNQVPRSVVLKPVDAAQTCTLTIEDGLNPPPNERQGASFGWAWLMALAPLAWWRRRQS
>NC_014541.1|WP_013345402.1|2125182_2125359_+|ribosome-modulation-factor
MKRQKRDKMDRAFSRGFQAGLTGRSKENCPYHAPDAKMHWLGGWREAIDGRETGLFTK
>NC_014541.1|WP_013345403.1|2125443_2125926_+|glutathione-peroxidase
MSGNIYQFSADLNGGEPQSLEAYRGKVLLVVNTASACGFTPQYEGLQKLQNEFGERGFSVLAFPCNQFGNQESGDDEAIRGFCDLRFNIDFPLFSKIDVNGNNAHPLFEWLKAEKGGWLGDNIKWNFTKFLVDREGRVVERFAPTTKPESIAGAIEKLLA
>NC_014541.1|WP_013345404.1|2125937_2126477_-|bifunctional-3-hydroxydecanoyl-ACP-dehydratase/trans-2-decenoyl-ACP-isomerase
MQVAEKLEPINASEYDKEALVESGHGRLFGEDAPRLPKDNMLMLDRISTINEHGGKYGKGEIIAELDIDPSLWFFDCHFESDPVMPGCLGLDAMWQLVGFFLAWQGAKGKGRALGVGEVKFTGQVLPEAKKVTYHIHLKRTIHRKLIMGLADATLSVDGREIYTATDLKVGVFQDTSSF
>NC_014541.1|WP_013345405.1|2126547_2128296_-|AAA-family-ATPase
MPQLRLAPSALKPHYPQLDPDATAPHTSPWMLGQERCVSAWSLFRRCSNQHLFVTAFPGFDGEALIEALHQQQPLQVSPGILASVVNGEAQALVKLTAEQFAKRTLPNGEAIPDEATLSALVELTPLRFVDQPLSRNTMLGSVDKSGAYHAGLLASSEVLVIPAEGLLQKPSRWFMVKEALKRGYIAFSGSPIQIPVCCKVVILGDVLDYDTLDALDPNFTDLFSLMAEAQPEWFVDSDEDAQLWGASAQQVSLLYTGRRLENGALTALARHASRSCEHQGRLTLAWHEMGLLLGQCESEGPITSERVQDALKQQRHRHNSVEIYAQRNVEEALVRVDTEGEKVGQINGLTVVDYCGHSYGEPARITVSVHYGDGEVADIERKSELGGNIHAKGMMILSACLYRIFGQDEPLHLSANIVFEQSYQTIDGDSASLAEYCSLISTIAEAPVKQGLALTGAIDQFGNVQAIGGINEKIEGFFHVCRYRGLTGSQGVILPRANTRQLNLSDDVIEAVESGQFHLFQVDNVEEALALLTGCEVGEPDKDNRFPDGTLYGLVQERLDQMAGNDEPERRPFWKRLFGFS
>NC_014541.1|WP_013345406.1|2128464_2129763_+|site-specific-integrase
MTSDRPPALPLFDTLRHFESSNPFINQHLASLVCQGIDDASLSYEHALDFLVEQRHNENNYKSHRSELTTFLHWCWCEEGVSLQQVDRRLLVRYLDYCQSPPPALIGYRNVAQFLAAKGETERRPNPNWRPFLGRMEMGEKLPYRLSVSAIKTKLALLSAFFTYLNDVEYTDRNPAALLLKRAKARYAGQSGLGEETPMKAFTELQWSYVLGAATRLANEQPEQYERTLFLVSLLYSCYLRVSEVSARPGFSPVMGQFRRDSKTGVWGFFVPMSKGGKSRTVALSDAMLNALKRYREYLGLPAMPAPKELTPLFCRHRAAQRGRDVGELNANLGQRQIRELVDGLISVASQDAAADGLADDAREMAEMTVHSLRHTGISHDINLNGRPLSHVQADAGHDSIDTTSHYLHTSQVERHQTARTKPLDHLGFAAD
>NC_014541.1|WP_171814260.1|2129759_2130581_-|tyrosine-type-recombinase/integrase
MACEGRPNRLTYNPHNGQSTLVSGPPLSVRSIRRRLSTLKWWMSQQGRSPNPAASTLVQDHLAGVVRLLPTRPKRAKGLGSDPMAELMHRMEEQEFVDLRDKTLLAVGFAGALRVSDLASLKIEDVRLYPNGANLGFETRKRRSEFSQVPIVAGQDPSRCPVALLQRYMMRLGAQQGPLFRRANRNRQPLAKPLHPSSVARIIMKRAQGIGMEASHGGVSGHSLRRGFIDSALLKGAPISEVMKISGHRDPKTLMLYLDDLGHFNSHPGQGLY

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Crispr_ID: NC_014541_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014541_3

4181745-4181820

Orphan

Consensus_repeat	Method
GGCCCCGCGTTAACAACAGAAGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014541_3

>merge|NC_014541|3|4181745-4181820|CRISPRCasFinder
GGCCCCGCGTTAACAACAGAAGCCCCCAGCGACCAGAAGCAGCGGTAGGCGATGGCCCTGCGTTAACAACAGAAGC

>NC_014541|3|3|4181745-4181820|CRISPRCasFinder
GGCCCCGCGTTAACAACAGAAGC	CCCCAGCGACCAGAAGCAGCGGTAGGCGAT
GGCCCTGCGTTAACAACAGAAGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_014541.1\|WP_013347206.1\|4175937_4177914_+\|hypothetical-protein	unknown	unknown	unknown
NC_014541.1\|WP_013347212.1\|4182485_4183193_+\|HAD-IA-family-hydrolase	unknown	unknown	gnl\|CDD\|182696
NC_014541.1\|WP_013347216.1\|4187533_4188376_+\|ribokinase	unknown	unknown	gnl\|CDD\|238922
NC_014541.1\|WP_041251907.1\|4182189_4182324_-\|DUF2956-family-protein	unknown	unknown	gnl\|CDD\|378579
NC_014541.1\|WP_049779606.1\|4172180_4172399_-\|DUF2956-family-protein	unknown	unknown	gnl\|CDD\|378579
NC_014541.1\|WP_013347203.1\|4171254_4172199_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176114
NC_014541.1\|WP_013347211.1\|4181843_4181990_+\|hypothetical-protein	unknown	unknown	unknown
NC_014541.1\|WP_013347201.1\|4169376_4170267_+\|tyrosine-recombinase-XerC	unknown	unknown	gnl\|CDD\|234698
NC_014541.1\|WP_013347205.1\|4174059_4175931_+\|hypothetical-protein	unknown	unknown	unknown
NC_014541.1\|WP_013347217.1\|4188444_4189503_+\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NC_014541.1\|WP_013347214.1\|4185403_4185700_-\|DUF1496-domain-containing-protein	unknown	unknown	gnl\|CDD\|369340
NC_014541.1\|WP_013347204.1\|4172500_4174063_+\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271175
NC_014541.1\|WP_013347207.1\|4177910_4178363_+\|hypothetical-protein	unknown	unknown	unknown
NC_014541.1\|WP_013347218.1\|4189544_4191179_-\|electron-transfer-flavoprotein-ubiquinone-oxidoreductase	unknown	unknown	gnl\|CDD\|223717
NC_014541.1\|WP_013347215.1\|4186085_4187420_+\|coproporphyrinogen-III-oxidase-family-protein	unknown	unknown	gnl\|CDD\|181509
NC_014541.1\|WP_013347208.1\|4178436_4178955_+\|hypothetical-protein	unknown	unknown	unknown
NC_014541.1\|WP_013347213.1\|4183236_4185402_+\|DNA-helicase-II	unknown	unknown	gnl\|CDD\|236976
NC_014541.1\|WP_013347219.1\|4191516_4192497_+\|GTP-3',8-cyclase-MoaA	unknown	unknown	gnl\|CDD\|234672
NC_014541.1\|WP_013347209.1\|4179150_4179948_+\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|277349
NC_014541.1\|WP_013347202.1\|4170311_4171148_-\|NAD(P)H-binding-protein	unknown	unknown	gnl\|CDD\|187578

Protein	Function_ID	Function_description	E-value
NC_014541.1\|WP_013347212.1\|4182485_4183193_+\|HAD-IA-family-hydrolase	gnl\|CDD\|182696	PRK10748, PRK10748, 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase YigB.	1.52963e-46
NC_014541.1\|WP_013347216.1\|4187533_4188376_+\|ribokinase	gnl\|CDD\|238922	cd01947, Guanosine_kinase_like, Guanosine kinase-like sugar kinases. Found in bacteria and archaea, the guanosine kinase-like group is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time.	5.3058e-55
NC_014541.1\|WP_041251907.1\|4182189_4182324_-\|DUF2956-family-protein	gnl\|CDD\|378579	pfam11169, DUF2956, Protein of unknown function (DUF2956). This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	1.14372e-12
NC_014541.1\|WP_013347214.1\|4185403_4185700_-\|DUF1496-domain-containing-protein	gnl\|CDD\|369340	pfam07383, DUF1496, Protein of unknown function (DUF1496). This family consists of several bacterial proteins of around 90 residues in length. Members of this family seem to be found exclusively in the Orders Vibrionales and Enterobacteriales. The function of this family is unknown.	5.6114e-15
NC_014541.1\|WP_013347215.1\|4186085_4187420_+\|coproporphyrinogen-III-oxidase-family-protein	gnl\|CDD\|181509	PRK08629, PRK08629, coproporphyrinogen III oxidase family protein.	0
NC_014541.1\|WP_013347201.1\|4169376_4170267_+\|tyrosine-recombinase-XerC	gnl\|CDD\|234698	PRK00236, xerC, site-specific tyrosine recombinase XerC; Reviewed.	1.16451e-141
NC_014541.1\|WP_013347203.1\|4171254_4172199_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176114	cd08422, PBP2_CrgA_like, The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain. This CD includes the substrate binding domain of LysR-type transcriptional regulator (LTTR) CrgA and its related homologs. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis further showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.28554e-57
NC_014541.1\|WP_013347202.1\|4170311_4171148_-\|NAD(P)H-binding-protein	gnl\|CDD\|187578	cd05269, TMR_SDR_a, triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs. TMR is an atypical NADP-binding protein of the SDR family. It lacks the active site residues of the SDRs but has a glycine rich NAD(P)-binding motif that matches the extended SDRs. Proteins in this subgroup however, are more similar in length to the classical SDRs. TMR was identified as a reducer of triphenylmethane dyes, important environmental pollutants. This subgroup also includes Escherichia coli NADPH-dependent quinine oxidoreductase (QOR2), which catalyzes two-electron reduction of quinone; but is unlikely to play a major role in protecting against quinone cytotoxicity. Atypical SDRs are distinct from classical SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	3.88718e-69
NC_014541.1\|WP_013347217.1\|4188444_4189503_+\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	6.89767e-62
NC_014541.1\|WP_013347204.1\|4172500_4174063_+\|site-specific-integrase	gnl\|CDD\|271175	cd00397, DNA_BRE_C, DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine based site-specific recombinases (integrases) that share the same fold in their catalytic domain containing conserved active site residues. The best-studied members of this diverse superfamily include Human topoisomerase I, the bacteriophage lambda integrase, the bacteriophage P1 Cre recombinase, the yeast Flp recombinase, and the bacterial XerD/C recombinases. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. The enzymes differ in that topoisomerases cleave and then rejoin the same 5' and 3' termini, whereas a site-specific recombinase transfers a 5' hydroxyl generated by recombinase cleavage to a new 3' phosphate partner located in a different duplex region. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.	2.6689e-05
NC_014541.1\|WP_013347218.1\|4189544_4191179_-\|electron-transfer-flavoprotein-ubiquinone-oxidoreductase	gnl\|CDD\|223717	COG0644, FixC, Dehydrogenases (flavoproteins) [Energy production and conversion].	2.74583e-96
NC_014541.1\|WP_013347213.1\|4183236_4185402_+\|DNA-helicase-II	gnl\|CDD\|236976	PRK11773, uvrD, DNA-dependent helicase II; Provisional.	0
NC_014541.1\|WP_013347219.1\|4191516_4192497_+\|GTP-3',8-cyclase-MoaA	gnl\|CDD\|234672	PRK00164, moaA, GTP 3',8-cyclase MoaA.	9.36607e-176
NC_014541.1\|WP_013347209.1\|4179150_4179948_+\|metallophosphoesterase	gnl\|CDD\|277349	cd07404, MPP_MS158, Microscilla MS158 and related proteins, metallophosphatase domain. MS158 is an uncharacterized Microscilla protein with a metallophosphatase domain. Microscilla proteins MS152, and MS153 are also included in this family. The domain present in members of this family belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	9.18927e-41
NC_014541.1\|WP_049779606.1\|4172180_4172399_-\|DUF2956-family-protein	gnl\|CDD\|378579	pfam11169, DUF2956, Protein of unknown function (DUF2956). This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	9.85025e-20

>NC_014541.1|WP_013347209.1|4179150_4179948_+|metallophosphoesterase
MRVHIMSDLHLEHFNKPSDWIPPIVEADALVLAGDIGVLDEPYIDWLSSVSKRYSAVIMVLGNHEYYQDGLTVQTAHSAWLNAIERLGNAYCLQDESVIIDNVRFVGTTLWTDYSVHGEESRGVGMRLAEQKMNDHRRISMSDSMGQRRFFPDDALSLHLSSRKYIEKTLTTTHSGPTVVVTHHAPHPVCIHPRYQNDLLTVAYASDLDELIKQHRPELWIHGHLHNCVDRDVHGTRIVCNPRGYPLDMWTPQNQWFKPDLVISV
>NC_014541.1|WP_013347208.1|4178436_4178955_+|hypothetical-protein
MSENMKKKLLGHYEEGLIDFYYLSNWANKRVVDFFYLDDDCVNGDKYEMKDHFELKVRKIHSTELYAKAQIWAGKDKRRSLTDEEKANIRFQEYSAMMDLICEVFTDKELNKLYASVRKIKSERSKRGDDKPTKITVRYGTRDALNSLAKERGLTMDALLQELIKGCNVPSA
>NC_014541.1|WP_013347207.1|4177910_4178363_+|hypothetical-protein
MSEQLKLSEARLQAAFERLVSGKPLKVKASGRLTLNKINNEAGFAKGYVHKFPEFMERIKPLIEDYNYKREQALASGLDIEIDAPLSEMDVLRAKLKKAERLKEKYRTERDNAVEARKQLEMNYSELSFRYYELQETVKAQGSVMTPIKR
>NC_014541.1|WP_013347206.1|4175937_4177914_+|hypothetical-protein
MNMALHQVLPEQEENPFVSFNSAGEGKSRLYDEIWDFTALAQPKREVRFTGVDLTHRHNIQRLTAQYMQHKIAQSSANHFTVHALARFKDKLWGIAKHWGKSDYSLLSHDWEWRDCKASLKGKYGIETLKAFAGIINALHDLGVTSRHTTEREMVVLKHVEKTEQQHVAFPPAMHAHWLTAAVEIVEKYHPYRQEISTCMMEYTRQMLAIYDQHLVESGTTDFTHDEQVKTSARCCRAARKIEAGSSVPGLKCDSDATFVSRLVMASFMVVGLFSGARKTELVSMNPKSYQIKDGIPVLMGLTSKGNEGQPITAVWQTHPIAKQALELAYDATQYARELHKVILSRHRAKGRIDEDRYQRAMVELGAAFIPAALRNTAFDGQLRTSYHLSSIDKSFNAERYFQPATADDVREFDLLNPSRAGELEVGGYSTKFSPHDMRRSFAVFLVRNKLGNLLTIKHQFKHKNLSMSGWYANNAELARMEGIMLDGELTAMFDEAMEDVAVDALDEVYNESSHLSGVEGERIAKSKEEALRRGETILLSRSELRALVRSGDKSIVMLPTGSYCTNPTCERLCSISQFHTESKPCEHEIITDRGARIKAREHRSLVESFREMNAMEDYALSSILEGERQKILYLEQTLTQHNIDFEPFKDEIKAVMA
>NC_014541.1|WP_013347205.1|4174059_4175931_+|hypothetical-protein
MSRRRIRIEPTQIVKTASVSTLSIDGMEFRTSNGRSFHLKRLRYRWVPTLRQIEKHPEALVNAERDDQIRSLHKLLQSNPNRALAELRTGGLVYFRYLDSFNYSGDLFDIDTMDAALKHFNRLALTGEAPSAATHVLAFLQYCLGLMGRAADRRKLPKVKKPEASGRQGALDAASIKLVAQVLRKGQSGFAKHIEDGTIPEIHPCFDEAIFNNTAKEQGWSPRQCADKKKGLRYLMRPSQRGGSEYLQSSALTAQQLEFKPIADHASRCALYTFFMLTGMNFSVLASMTFGDVTFTSIHGGRYIFRGLKARAGYKEIDNSLGLSKHTKEMIEAWFSTSKQIYRRMGHEPTAGKPLFPYFTRNNEVWDFTQCGTRPQSINLVIEKVVGIPISASKFRNTKADMLMRATESVFIVSQGLNNTVKVVERRYTSGVQGDHENNLKAVNDAQYAIAKGEEFSAAVQQAKVLNSDILSDYDYKQRLMRGNAPKTTLTPSGIRCQGASPDKLMSESRKAKNMGFPLSEGAEKCTDFLACYDCDKHMLIASETDIWLMLSFQTQLARMEDIPAKNSAPKDKARMIEAVIARTLQRMQEKAPKAYQQAVERIDRAEYHPLYKSHISIQYLVG
>NC_014541.1|WP_013347204.1|4172500_4174063_+|site-specific-integrase
MIQTEQGCVVETSVITNCRYKKPIATINEDGEVVIVYSPHDQKTGGTLIKKVTLLNMVAYNDKGEVLSFKPIDVANNFILSKHLNDGVQKSDRYSQGLAMYFQFVLDSQAEWDAAFERGDVDPEWGDVRPDWNHFPRAKSERLTYQFRDKLKELATASDGAMAKSVAKSYLSAVVSFYKYWLHRSPHLISGEPFEFENISLLLDAGATSMKRHYAKQIQTTDLRLKFAKPSLSGGTSLDHLRRDLKPFTNEEWRVLHNVIEKSRRVIRKGKSGRLESLPIEYSLHFMTCRFTGLRSEEAASLHLGQIVRPATKIEEGREVFTRGILSLGVGDQYGSWTKTPEAGNKSRTTIIPAKLMQSLYEYTQSERYKKRLAKFKLWCEQQHESGNTALFEGHDGVNRDRHYLFISQTGKPMMLSVNEFSNRWTEVRDTANRTEGVQRPIVGSLHNLRATFAVNVFRHLLKTITPDDALARVSSLLGHENYDTTLMYLKIAQDHPSADEIYEDILNYTGVFDDWEGAQ
>NC_014541.1|WP_049779606.1|4172180_4172399_-|DUF2956-family-protein
MEKGIAEYKKQQKAKARAADKARKQARRAKARDAEEAEEVVMEGAGPASSGRVAWALLVLSWAGFAAYLLLS
>NC_014541.1|WP_013347203.1|4171254_4172199_+|LysR-family-transcriptional-regulator
MQESLAQIRRLAIFATVVEQGSFSAAGRKLGLGRGKVSEQISALEQALSVRLLQRSTRQLSVTAEGQVLYRHCRDLLPQASQGLREVQDLGPEPMGRLRLTTTSDVAQQVLSPFLSRFCQQYPGIQLDLQLADAVLNLVEEDIDIAIRIGTPVDSSMVGIELGALPMGLYAATSYLAQWGVPESLPDLSAHRGVQMTRMPNLSTLMLSNDEGVSQPAGLPVFHRTDTPAGNATLVEQGLGIGLLPHFTLNQAVSEGRVRPVLPQWQYRQLAITLLFPSRAQLPRRSRLFIDALRDWLRDGEGKMRLQPAQLNSK
>NC_014541.1|WP_013347202.1|4170311_4171148_-|NAD(P)H-binding-protein
MTTVFVTGASGALGQALIQQLSDTGLTVIAGSRTPKPQPGIQAVAFDYDRPQTFEALKGVDKLVMIPRPADVIADQVMIPVIEAAKAAGVKQIVLSTALGVDANEEAPLRKVERALFASGLDYTVVRPSWFFDNFLKPGEVASIRQGVLVAPASDGKGSFIAARDIAAAIIAALLDSRHNGAAYTLTGPQAVTHAEVAAALSSALGHKVSHLDIAPVEYGALLTKAGLTDSQVGFYQFLYELTRIGVFGAVTSDLEAMTGQPGQDLAGFVAEHLGAWQ
>NC_014541.1|WP_013347201.1|4169376_4170267_+|tyrosine-recombinase-XerC
MNNALQAFRGYLENERQYSAYTVRNYLKELERALPLLQAQGLTDWQGLRTQHCQALLAKLHRQGLSPRSLSLTLSALRQLIKFLLREGTLTHDPMVGVQAPKQGRPLPKNLDVDQVNRLLELNDDDPLVIRDRAMMELFYSSGLRLAELVALDCPQLSLTDREVRVMGKGGKERILPVGNKASEWLAKYLALRPALLKGKECAALFLSNRGSRISRRSVQARLTEWGQSQALDSKVHPHKLRHSFATHLLEASKDLRAVQELLGHANLSTTQIYTHLDFQHLASVYDTAHPRAKKK
>NC_014541.1|WP_013347211.1|4181843_4181990_+|hypothetical-protein
MKMKAERKITEAKKAKLGGMTKLRAAYLEAKAEGRVRSCRITGVRLSL
>NC_014541.1|WP_041251907.1|4182189_4182324_-|DUF2956-family-protein
MAKANTNAQSVSPEVVAEAMKIARGTQQPGQTKEQTKLIAKGID
>NC_014541.1|WP_013347212.1|4182485_4183193_+|HAD-IA-family-hydrolase
MRFYRRLQPVQALSFDLDDTLYDNTPVLQAAERRLLQRLQTESRDPRASDPQWWQQQKAQTLQRSPELGHDTTLTRQATLAHGLAELGHPAPQAASKALMTQFLIWRSEIGVSEPVVNLLLELAERYPLAVITNGNADVRRFLPQVPFATVHCAGPDGPQKPAPALFHQCCQALAIAPAQLLHIGDHPGTDVLGAIRAGCQAALLQPGANGRIRPSGPALPTLEFDSLEALRQWL
>NC_014541.1|WP_013347213.1|4183236_4185402_+|DNA-helicase-II
MTSRLQLDTLNDKQRAAVEAAPGAVLVLAGAGSGKTRVLTHRIAWLLEEQGESPYAILAVTFTNKAAAEMRHRIEDLVHGPVNRMWIGTFHGLAHRLLRAHYQEAGLPEGFQILDSDDQQRLVKRILKSLQLDEKRWSPRQAVGYINAKKDEGLRPQHIDAGYHPVEKTFLQIYQAYQEACDRAGLVDFAELLLRAHELWLKQPHLLRHYQQRFRHILVDEFQDTNAIQYAWIRMLASDGSHIMIVGDDDQSIYGWRGARVENLQKFLDDFPGAQTIRLEQNYRSTSTILSAANALIAHNAERMGKELWTEGATGEPISLYCAFNELEEARYIVGRIKQHLDGGGALSDCAILYRSNAQSRVLEEALLHQSVAYRIYGGLRFFERQEIKDALGYLRLIANRHDDAAFERIVNTPTRGIGDRTLDIVRATARAEGITLWRACQRLLSERGLAGRAASAVAAFISLIDQLEEEVMDAPLKRQADHVINHSGLRAMYEAEKGEKAEARIENLNELVTAAGSFERPEDSEEMSELNAFLAHAALEAGEGQADDNDDAVQLMTLHSAKGLEFPLVFMCGVEEGMFPSQMALDEGDRLEEERRLCYVGMTRAMQKLYITYAESRRLYGRETFAKASRFIREIPQEHLDEVRLTTQVSQPRQYNRFNQSEQRFNDTGFSLGQRVHHPKFGDGVIINYEGSGPQSRVQVAFDGMGVKWLVVAYARLEAR
>NC_014541.1|WP_013347214.1|4185403_4185700_-|DUF1496-domain-containing-protein
MKIRVLMIGLLVTTGALAQVERPARVISTGPKPIPVVDGAEFVRACWYQGQQYSEGAPLEVGGKLLYCLPKNDYETNGALIWRSADAEPAPAKIRINP
>NC_014541.1|WP_013347215.1|4186085_4187420_+|coproporphyrinogen-III-oxidase-family-protein
MSLAERALNNAAIRESNKITTPRWMLDSLEHVMQYYTKRHLCLDTQACDAFPAPIPGRKYMLYMHVPFCHTLCSFCTFHRFLFKEEKARAYFISLRKEMEMAKALGYDFEELYIGGGTTTVLVDELARTIEHARNLFPGIKQVSCESDPLHLTSAEFTQLHGLVDRLSVGVQSFNRDILARTDRLEKFGEPEVVYEKLLRAKDNFPILNVDMIFGFQGQTEEVLQNDMDMLTRLGPRQITTYPLMVTHQTRKSAKGNLAAADQDIRKDYELILNSLKGHYDQLTAWSFGKSNEEGFDEYVVNYDDYLGLGSGSFSFLHDTLYVNSFSLRRYQERIAAGKMGVESSKHYSRHAVMQYRFLLNLFGGRISKSYFKDQFGVSPYLGLAKEMAFMHATGCLKQDPTDADKLQATPNGLMMGLLMMKNFYAGMDNVRAELRRPLGAKDM
>NC_014541.1|WP_013347216.1|4187533_4188376_+|ribokinase
MSRILIIANLNCDHILRLSRPLSSGARIHYEDLGHRIGGGATNTGLGLVWAGHQVALLSQVGNDKLGDWLLDEARQLGLNCDQVHRLVGPTQPLQLLMEPDGERTILRPNRPRLLLPQRLDWQATDALYVNLSAEHLPNLMADALASTLVVAQLPKDLAVRPSHYLITSQDDLAQHGVEPSFEWAQSIAGPSLRAFIVTAGAEGACAYLPGTSLQQSAVAATVVDSTGAGDCYAAGLIHGLLSQGELSQAMAEAARWAAFAVSAESSIPPQALHSYLASA
>NC_014541.1|WP_013347217.1|4188444_4189503_+|GGDEF-domain-containing-protein
MELDPRPVQYKGLQWLLIFATLTPLASVFLYEWSQPLERQAPYLLNATLAVLLWGLNRRAHRRKRFQLAMPIEVQGLLLGLAVSTVVVARLTGNDGGPILPVFSAYVMFVFASVLGLHSADRALLMCLAPPTLVLLWPSGVLWWQELAVLVITLYLGFAARRQINLWMRMSQAQLRQNKRLLEKFRTLSNQDPLTGLGNRRCFEQRLAQSVSEAKRSKNALSLILLDVDYFKRYNDHFGHQAGDECLRTVAQILRLSSRRQSDTLARIGGEEFVLLLPNTDKRGAQRLAEEIQSRLLQADLDHPQSGISKRVTLSQGIAQWHPGLSGDALMHQADKAMYESKLAGRNTISAA
>NC_014541.1|WP_013347218.1|4189544_4191179_-|electron-transfer-flavoprotein-ubiquinone-oxidoreductase
MERESMEFDVLVVGAGPAGLSAAIRLKQLNAELNVCVVEKGSEVGAHILSGAVFEPRALNELLPEWREQGAPLDTPVTDDEIWLLDSKGGRQFPNWLTPKTMHNDGNYIISLGNLCRWLAEQAEGLGVEIYPGFSAAELIEQDGVIGGVITGDMGVGLDGSEKDGYMPGMELRARYTLFAEGCRGHLGKALIARYQLDAGRSPQHYGLGFKEIWQLPEGATKPGKVVHTAGWPLSEHGASGGSYLYHADNNQVLVGLIVDLNYDNPNLNPFEEFQRFKTHPEIAKHLEGGERISYGARAIAKGGFNSLPKMSFPGGLLIGCDAGTLNFAKIKGSHTAMKSGMLAAEVVAEALSDAEAGVQDLTQFEAHFKASWLYDELYRSRNFGPALHKFGSMLGGAFNTLDQNLFGGRLPITLKDEHRDHAQLQPAAQAVAIQYPKPDGKLSFDRLSSVFLSNTYHEEDQPCHLKLTDAAIPVQVNLAQFDEPAQRYCPAGVYEIVEEGGTPRLQINAANCIHCKTCDIKDPSQNITWVTPEGGGGPNYPNM
>NC_014541.1|WP_013347219.1|4191516_4192497_+|GTP-3',8-cyclase-MoaA
MRELQDRFGRSFPYLRLSITDACNFKCEYCLPNGYHPDGKPRFMTLDEIRRVLHAFSTVGMRKVRITGGEPTLRKDFEEVLQLAANTPGVDTIATTTNGYRLAEHARAWHQAGLSQVNVSVDSLDPANFQRITGDSRFDLVMKGIDAALNEGYRKVKINVVLLKGLNGGELPLFLDYIKHQPVDLRFIELMETGLHHDYFQAHHLPGTVIQAQLERQGWQLDPRGPDDGPALNYSHPDYAGRIGLIMPYAKDFCASCNRLRVSAIGKLHLCLFTEAGIELRDLLGSDDQQEELIARLHAALGQKHQTHYLHEGDAGATPHLASIGG

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_014541_3	3.1\|4181768\|30\|NC_014541\|CRISPRCasFinder	4181768-4181797	30	NZ_AP014705	Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence	323091-323120	7	0.767
NC_014541_3	3.1\|4181768\|30\|NC_014541\|CRISPRCasFinder	4181768-4181797	30	NZ_CP034811	Paracoccus sp. Arc7-R13 plasmid unnamed1, complete sequence	150907-150936	7	0.767
NC_014541_3	3.1\|4181768\|30\|NC_014541\|CRISPRCasFinder	4181768-4181797	30	NZ_CP009572	Sphingomonas taxi strain ATCC 55669 plasmid STP1, complete sequence	159600-159629	7	0.767
NC_014541_3	3.1\|4181768\|30\|NC_014541\|CRISPRCasFinder	4181768-4181797	30	NZ_CP049817	Monaibacterium sp. ALG8 plasmid unnamed6, complete sequence	3358-3387	8	0.733

1. spacer 3.1|4181768|30|NC_014541|CRISPRCasFinder matches to NZ_AP014705 (Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence) position: , mismatch: 7, identity: 0.767

ccccagcgaccagaagcagcggtaggcgat	CRISPR spacer
gttgagcgaccagaagcagcggtagtcgcg	Protospacer
 .. ********************* **

2. spacer 3.1|4181768|30|NC_014541|CRISPRCasFinder matches to NZ_CP034811 (Paracoccus sp. Arc7-R13 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.767

ccccagcgaccagaagcagcggtaggcgat	CRISPR spacer
gttcagcgaccagaagcatcggtagtcggc	Protospacer
 ..*************** ****** **..

3. spacer 3.1|4181768|30|NC_014541|CRISPRCasFinder matches to NZ_CP009572 (Sphingomonas taxi strain ATCC 55669 plasmid STP1, complete sequence) position: , mismatch: 7, identity: 0.767

ccccagcgaccagaagcagcggtaggcgat	CRISPR spacer
gttgagcgaccagaagcagcgatagtcgtt	Protospacer
 .. *****************.*** ** *

4. spacer 3.1|4181768|30|NC_014541|CRISPRCasFinder matches to NZ_CP049817 (Monaibacterium sp. ALG8 plasmid unnamed6, complete sequence) position: , mismatch: 8, identity: 0.733

ccccagcgaccagaagcagcggtaggcgat	CRISPR spacer
gttcagcgaccagaaacagcggtaatcgcg	Protospacer
 ..************.********. **

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

928846 : 943224

uncultured_Mediterranean_phage(25.0%)

tRNA

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_041251509.1\|928846_930142_+	phosphopyruvate hydratase	A0A1X9I5Z8	Streptococcus_phage	1.6e-133	59.8
WP_013344361.1\|930245_930527_+	cell division protein FtsB	NA	NA	NA	NA
WP_013344362.1\|930543_931242_+	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	NA	NA	NA	NA
WP_041251183.1\|931238_931715_+	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	NA	NA	NA	NA
WP_013344364.1\|931707_932760_+\|tRNA	tRNA pseudouridine(13) synthase TruD	NA	NA	NA	NA
WP_013344365.1\|932773_933520_+	5'/3'-nucleotidase SurE	A0A1B1ITZ2	uncultured_Mediterranean_phage	1.1e-73	54.9
WP_013344366.1\|933516_934155_+	protein-L-isoaspartate(D-aspartate) O-methyltransferase	A0A1B1IU40	uncultured_Mediterranean_phage	1.7e-35	49.7
WP_013344367.1\|934155_935070_+	peptidoglycan DD-metalloendopeptidase family protein	A0A292GJG6	Xanthomonas_phage	9.0e-14	41.5
WP_013344368.1\|935145_936132_+	RNA polymerase sigma factor RpoS	G8CLC7	Synechococcus_phage	8.4e-34	37.6
WP_083771270.1\|936188_938711_-	DNA mismatch repair protein MutS	A0A1V0SC35	Catovirus	2.6e-31	22.0
WP_013344370.1\|938950_939991_+	recombinase RecA	A0A2D1GPX2	Mycobacterium_phage	9.9e-118	63.2
WP_013344371.1\|939997_940456_+	regulatory protein RecX	NA	NA	NA	NA
WP_013344372.1\|940593_943224_+\|tRNA	alanine--tRNA ligase	A0A1V0SK38	Klosneuvirus	3.3e-77	38.1

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_014541

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection