CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_022663	Mycobacterium kansasii ATCC 12478, complete sequence	20 crisprs	WYL,cas4,DEDDh,csa3,DinG,cas3,PD-DExK	17	22	4	0
NC_022654	Mycobacterium kansasii ATCC 12478 plasmid pMK12478, complete sequence	0 crisprs	c2c9_V-U4	0	0	1	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_022663_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022663_1

466737-466850

Orphan

Consensus_repeat	Method
GGCTGACCGTATTGGCCGGGCTGG	CRISPRCasFinder

2 spacers

WYL

The CRISPR arrays of NC_022663_1

>merge|NC_022663|1|466737-466850|CRISPRCasFinder
GGCTGACCGTATTGGCCGGGCTGGCCGGGCGCCCCGTACTGGCCGGGCTGGCCGTACTGTGCCGGCTGGCCGTATTGGCCGGGCTGGGCCGCCTGACCGTACTGCCCGGGCTGG

>NC_022663|1|1|466737-466850|CRISPRCasFinder
GGCTGACCGTATTGGCCGGGCTGG	CCGGGCGCCCCGTACTGGCCG
GGCTGGCCGTACTGTGCCGGCTGG	CCGTATTGGCCGGGCTGGGCC
GCCTGACCGTACTGCCCGGGCTGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_022663.1\|WP_023364664.1\|461937_464178_-\|peptidase	unknown	unknown	gnl\|CDD\|273828
NC_022663.1\|WP_080673985.1\|469934_470888_-\|twin-arginine-translocase-subunit-TatC	unknown	unknown	gnl\|CDD\|223876
NC_022663.1\|WP_023364672.1\|472229_473228_-\|YafY-family-transcriptional-regulator	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|225253
NC_022663.1\|WP_133163582.1\|460264_460498_+\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_023364675.1\|480280_481654_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340887
NC_022663.1\|WP_080673984.1\|461418_461910_+\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_023364671.1\|471264_472233_-\|YafY-family-transcriptional-regulator	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|225253
NC_022663.1\|WP_023364674.1\|475972_479938_-\|non-ribosomal-peptide-synthetase	unknown	unknown	gnl\|CDD\|237108
NC_022663.1\|WP_036396015.1\|456989_457283_-\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_080673983.1\|460586_461372_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|283837
NC_022663.1\|WP_023364677.1\|482876_484658_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|165707
NC_022663.1\|WP_023364670.1\|470930_471197_-\|Sec-independent-protein-translocase-subunit-TatA	unknown	unknown	gnl\|CDD\|234797
NC_022663.1\|WP_023364660.1\|459802_460261_+\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_023364668.1\|467186_469913_-\|RNA-helicase	unknown	unknown	gnl\|CDD\|226947
NC_022663.1\|WP_099184121.1\|473238_474597_-\|Pup--protein-ligase	unknown	unknown	gnl\|CDD\|274725
NC_022663.1\|WP_023364665.1\|464206_465328_-\|aminopeptidase-P-family-protein	unknown	unknown	gnl\|CDD\|223085
NC_022663.1\|WP_023364666.1\|465374_466331_+\|5'-3'-exonuclease	unknown	unknown	gnl\|CDD\|214682
NC_022663.1\|WP_023364676.1\|481671_482880_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380462
NC_022663.1\|WP_133163583.1\|455305_455908_-\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_129111943.1\|457418_457613_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_022663.1\|WP_023364664.1\|461937_464178_-\|peptidase	gnl\|CDD\|273828	TIGR01840, poly3-hydroxybutyrate_depolymerase_A_precursor, esterase, PHB depolymerase family. This model describes a subfamily among lipases of the ab-hydrolase family. This subfamily includes bacterial depolymerases for poly(3-hydroxybutyrate) (PHB) and related polyhydroxyalkanoates (PHA), as well as acetyl xylan esterases, feruloyl esterases, and others from fungi. [Fatty acid and phospholipid metabolism, Degradation].	3.14868e-07
NC_022663.1\|WP_080673985.1\|469934_470888_-\|twin-arginine-translocase-subunit-TatC	gnl\|CDD\|223876	COG0805, TatC, Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion].	1.44834e-77
NC_022663.1\|WP_023364672.1\|472229_473228_-\|YafY-family-transcriptional-regulator	gnl\|CDD\|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	5.48143e-60
NC_022663.1\|WP_023364677.1\|482876_484658_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|165707	PLN00139, PLN00139, hypothetical protein; Provisional.	1.09816e-33
NC_022663.1\|WP_023364670.1\|470930_471197_-\|Sec-independent-protein-translocase-subunit-TatA	gnl\|CDD\|234797	PRK00575, tatA, Sec-independent protein translocase subunit TatA.	4.7565e-39
NC_022663.1\|WP_023364671.1\|471264_472233_-\|YafY-family-transcriptional-regulator	gnl\|CDD\|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	2.18156e-76
NC_022663.1\|WP_023364674.1\|475972_479938_-\|non-ribosomal-peptide-synthetase	gnl\|CDD\|237108	PRK12467, PRK12467, peptide synthase; Provisional.	0
NC_022663.1\|WP_080673983.1\|460586_461372_+\|hypothetical-protein	gnl\|CDD\|283837	pfam06259, Abhydrolase_8, Alpha/beta hydrolase. Members of this family are predicted to have an alpha/beta hydrolase fold. They contain a predicted Ser-His-Asp catalytic triad, in which the serine is likely to act as a nucleophile.	3.55063e-11
NC_022663.1\|WP_023364675.1\|480280_481654_+\|MFS-transporter	gnl\|CDD\|340887	cd17329, MFS_MdtH_MDR_like, Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.40989e-22
NC_022663.1\|WP_023364668.1\|467186_469913_-\|RNA-helicase	gnl\|CDD\|226947	COG4581, COG4581, Superfamily II RNA helicase [DNA replication, recombination, and repair].	0
NC_022663.1\|WP_099184121.1\|473238_474597_-\|Pup--protein-ligase	gnl\|CDD\|274725	TIGR03686, pupylate_PafA, Pup--protein ligase. Members of this family are the Pup--protein ligase PafA (proteasome accessory factor A), a protein shown to regulate steady-state levels of certain proteasome targets in Mycobacterium tuberculosis. Iyer, et al (2008) first suggested that PafA is the ligase for Pup, a ubiquitin analog attached to an epsilon-amino group of a Lys side-chain to direct the target to the proteasome. [Protein fate, Degradation of proteins, peptides, and glycopeptides].	0
NC_022663.1\|WP_023364665.1\|464206_465328_-\|aminopeptidase-P-family-protein	gnl\|CDD\|223085	COG0006, PepP, Xaa-Pro aminopeptidase [Amino acid transport and metabolism].	1.69806e-103
NC_022663.1\|WP_023364666.1\|465374_466331_+\|5'-3'-exonuclease	gnl\|CDD\|214682	smart00475, 53EXOc, 5'-3' exonuclease.	1.08496e-89
NC_022663.1\|WP_023364676.1\|481671_482880_-\|hypothetical-protein	gnl\|CDD\|380462	cd19539, SgcC5_NRPS-like, SgcC5 is a non-ribosomal peptide synthetase (NRPS) condensation enzyme with ester- and amide- bond forming activity and similar C-domains of modular NRPSs. SgcC5 is a free-standing NRPS condensation enzyme (rather than a modular NRPS), which catalyzes the condensation between the SgcC2-tethered (S)-3-chloro-5-hydroxy-beta-tyrosine and (R)-1phenyl-1,2-ethanediol, forming an ester bond, during the synthesis of the chromoprotein enediyne antitumor antibiotic C-1027. It has some acceptor substrate promiscuity as it has been shown to also catalyze the formation of an amide bond between SgcC2-tethered (S)-3-chloro-5-hydroxy-beta-tyrosine and a mimic of the enediyne core acceptor substrate having an amine at its C-2 position. This subfamily also includes similar C-domains of modular NRPSs such as Penicillium chrysogenum N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase PCBAB. Condensation (C) domains of NRPSs normally catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity.	1.37402e-16

>NC_022663.1|WP_023364666.1|465374_466331_+|5'-3'-exonuclease
MSAPLLLLDGASMWFRSFFGVPSSITAPDGRPVNAVRGFIDSMAVVITQHRPGRLVVCLDLDWRPQFRVDLISSYKAHRVAETEPEGRPDIEEVPDELTPQVDMIMELLDAYGIPTAGAPGFEADDVIGTLAAQERHDPVVVVSGDRDLLQVVADDPVPVRVLYLGRGLSKATLFGPAEVAERYGLPADRAGSAYAELALLRGDPSDGLPGVPGVGEKTAAALLAAHGSLDQIMSAAHDPKSGMAKGLRAKVLGASDYIEVAGSVVRVATDSPVQLSTPTDALPLVAADPARTAELATRYGVGSSITRLQKALDALPA
>NC_022663.1|WP_023364665.1|464206_465328_-|aminopeptidase-P-family-protein
MNSRRFDSAVYERRLAAAAANTADAGLAGLVITPGYDLRYLIGSRAETFERLAALVLPASGEPTLVVPRLELATFMESADALGLGVRTWVDGDDPYRLVSAALGGGPVATGVSDSMPALHLLPLAAALDVLPVLATDVLRELRMIKEEAEIDALRRAGSAIDRVHARVPELLVPGRTEADVAADIAEAIVAEGHSEVAFVIVGSGPHGADPHHRFSDRTLQAGDIVVVDIGGTVEPGYHSDCTRTYSIGEPEPVVAQHYSVLQRAQRAAFDAVRPGVPAAQVDAAARCLLAEAGLADYFVHRTGHGIGLCVHEEPYIVAGNDVALAAGMTFSIEPGIYFPGRWGARIEDIVVVTKDGALSVNQRPHELTVVPV
>NC_022663.1|WP_023364664.1|461937_464178_-|peptidase
MSLLDLTLLPLRIARHVADVVVRPASPAPPAELVVVDGMPEGVPPAARKPEPKLPVPSGWPFGEEFPRTCGAARVAGGALFWTDFLYDDHGATGLPVGDLKVQAPPRGTYVYPAGPAAGNGADIFRVAIGLTETHTWWRVDWNTLVDATVPIALFTFDTDRGRAASADWPAGAGVRSAGIDMALLVSGRSARLIDLTTQVATPVEHSVDLPARSFLAQVPRSVLEPTGTWTVRLAAGLANAAGDGFADVPAEHGALPGQPNVYNVAFRTHDQEKPHLNFWSDAAQAAALTSGDVSEFAVAVQWDRLAARETAAEPVITGPSTRWYVSSVELGQGVADGTVLDTDPQFLGRVQPYSVCLPSTYAPGQALPLTLLLHSLALGQTQFAAIDPRLLHEVCETRGSVVVTPLGRGPSTWYFDAGELDVWEVWARVAEQLGTDPNRTVISGYSMGGYAAYKLGLSYPEVFAQAVVLAGPPTCGVRLLPNVDIPADLNLDSHCAREGDTWELLGNARWLPFVIAHGLIDELVPFASAAEQVLELDRLGYRYRFTVYPLEDHIAWVLQDKFDDPIAHMGTGLRQADPGHITFAWYPQLVRADLGIGPHQVWWLSELTADPAVTARRGATAEVDARSYARPDPMHSIRRHRGFVPHFDPTPGLYTELDWRVDGPAPVLPYLTLRLTGVASLTVDVERAGLASLPSSSIAVASDTAAQITLAGLPDGLQVRLDGQPVESIVAVPIGRHQISLVRTG
>NC_022663.1|WP_080673984.1|461418_461910_+|hypothetical-protein
MVLLLGGCSPMYPFAHDADHPEHPLSDEQAMAQVIEPAKQITKVAGLRDVSGGFSWESCNDQGDPPYRGRVDMTFNVPPGIDHSAYFEQVAATMVAHGWSSGAPSGQHLFGTAIHNDGVMATIGVSPFLGADGASELSGECRDMNNHRTDSNGFSIKDQLRGQ
>NC_022663.1|WP_080673983.1|460586_461372_+|hypothetical-protein
MGYDAPAFEFQSLEAAVTDPTKLQQVGTPWMARQGGAVLAADVNGLAVTHEGGTPSHVTVIGHSYGSTTVADAFANSGMRANDAVLIGCPGTDLAPSAADFHLNGGRVYVGAASTDAISWIAESGSAVPNWVNDALGAPLGPLAGLGTDPAHEGFGSVRFRAEVAGTHNVTPWFNDHSHYYNKGSEALHNITEITVGHGDHLAREGMLAPHRAEERISSPTQIRTPFGTIPLPHVEVTTPATVDPEWDRPGDSVTSDHDFK
>NC_022663.1|WP_133163582.1|460264_460498_+|hypothetical-protein
MNDSNASRTGCFLDERPFSSCGVMSISHRRRWLVCLAALTAAIFASGVCSSMYPFGNDPDHPERSLADEHAMDQVVK
>NC_022663.1|WP_023364660.1|459802_460261_+|hypothetical-protein
MYPFAHDADRPEHPLSDEQAMAQVIEPAKQIAKVAGLQDVSGEFGWESCNDQGDPPYRSRVNVKFNVPAGMDRNAYFEQVAATMVAHGWLAGPPPGLRPFGTAIHKDGVMAIIGVSPFLGADGDVELSGECRNMGDHRHARWLNISDQLRGG
>NC_022663.1|WP_129111943.1|457418_457613_+|hypothetical-protein
MVDQYPQEFSAIETRARANGAAGDGFSDYCRDPRRHKVIGVLLDGVCQAAADALQALHPHSWLG
>NC_022663.1|WP_036396015.1|456989_457283_-|hypothetical-protein
METGELRVDVYQLRASASQWRELSTRFSVLASPTPGRPCQPTTAAVGGAHTAVGLAAEVLTIRTQATTGAVKAGAEGYGSNEVTAAGEMAAVRPRMV
>NC_022663.1|WP_133163583.1|455305_455908_-|hypothetical-protein
MNAYSIRELYEFAPDVMLTTVSKANPLIEQGALNEAEFIDMRLSPQRSRAGIIFDIRWSGFEDSNTALVVLTGVGKVDWSNDASRQYPWYSTRGYWTPTTSNIPPLIAPNGGDIWARDADRPGTVADPRAMPAIEKLTEYVLKFDWLSMSGLTARIYIGHVDGLDGAPPDMTELSDAEIIAGFPQWESVMEVREQYTYSP
>NC_022663.1|WP_023364668.1|467186_469913_-|RNA-helicase
MTDLPELTRFIAELPFSLDDFQRRACAALECGHGVLVCAPTGAGKTVVGEFAVHLALAAGGKCFYTTPLKALSNQKHTDLTARYGRDQIGLLTGDLSVNANAPVVVMTTEVLRNMLYADSPALQGLSHVVMDEVHFLADRMRGPVWEEVILQLPEEVRVVSLSATVSNAEEFGGWMQTVRGDTTVVVDEHRPVPLWQHILVGKRLFDLFAYDADAEQPRVNPDLVRHIAHRREADRMSDWQPRRQGGRGGPGRSRFYRPLPRPEVIAKLDSEGLLPAITFVFSRAGCDAAVQQCLRSPLRLTGEDERARIAEVIDHRCGDLADADLAVLGYYEWREGLQRGLAAHHAGMLPAFRHTVEELFAAGLIKAVFATETLALGINMPARTVVLERLVKFNGEQHLPLTPGEYTQLTGRAGRRGIDVEGHAVVIWHPSDNTSEPAEVAGLASTRTFPLRSSFVPSYNMTINLVHRMGPEQAHRLLEQSFAQYQADRSVVGLVRGIERGKRMLDEIAAELGGPNAPILNYARLRAQVSELERSQARASRLQRRQEANDALAALRKGDIITITHGRRGGLAVVLESARDSADPRPLVLTENRWAGRISSADYSGGAPPVGSMALPKRIEYRQPRVRRDLASALRSAAAGLPAPADRRGKKRTRQDPDLESLREQLRRHPCHHAGDVEVQVRQAERYLRIERDNTQLQRKVAAATNSLARTFDRIVGLLTERQFIHGPPTDPEVTDDGRLLARIYSESDLLVAECLRTGAWAGLKPPELAAVVSAVLYESRGSDEPSGVEAPTPGLRQALRQTARLSAQLRADEQTHRISQSREPDDGFVNVIYRWARTGDLGAALAAADVSGTGSPLSAGDFVRWCRQVLDLLDQVRNAAPDPEVRAVAKRAINDIRRGVVAVDAG
>NC_022663.1|WP_080673985.1|469934_470888_-|twin-arginine-translocase-subunit-TatC
MGNGFRASARAATVLKRLNPRNRRSRVNPDATMSLVDHLTELRTRLLISLAAILITTIFGFIWYSHSVFGLQSLGEWLRHPYCSLPQSARADISADGQCRLLATAPFDQFMLRLKVGMTAGVVLACPVWFYELWAFITPGLYKKERRFAVAFVIPAAVLFVAGAVLAYLVLSKALGFLLTVGSDVQVTALSGDRYFGFLINLLVVFGVSFEFPLLIVMLNMTGMLTYERLKSWRRGLIFTMFVFAAVFTPGSDPFSMTALGVALTVLLELAIQIARLHDKRKAKREALIPDDEASAIDSPEPVPAPSVIGGSHDDVT
>NC_022663.1|WP_023364670.1|470930_471197_-|Sec-independent-protein-translocase-subunit-TatA
MGSLSPWHWAILAVVVIVLFGAKKLPDAARSLGKSMRIFKSEMREMQSETKNQPPALDTNPASPTPVQSQRVEPPASTEPGHTEARPA
>NC_022663.1|WP_023364671.1|471264_472233_-|YafY-family-transcriptional-regulator
MTAVSTRLVRLLNMVPYFQANPRITRAEAATDLGVSAKQLEEDLNQLWMCGLPGYYPGDLIDFEFSGDTIEVTFSAGIDRPLKLTSPEATGLLVALRALADIPGVVDPRAARSAIAKISAAAGAAGPASTVSAADQPAPAEHAAAATVRAAVRDKRALTIDYYSASHDTLTTRTVDPIRVLLIGGHSYLEAWSREAEGVRLFRFDRIVEASELDEPAAPPEPALQAPPDTALFDADPSLPSATLRVAPSASWMLEYYPIRELRELPDGSCEVAMTYASEEWMTRLMLGFGSDVQVLAPDSLARRVRAAAEAALQAYRAAAQE
>NC_022663.1|WP_023364672.1|472229_473228_-|YafY-family-transcriptional-regulator
MATSKVERLVNLVIALLSTRGYITAEKIRSSVAGYSDSPTAEAFSRMFERDKNELRDLGIPLEVGKVSNLDPTEGYRINRDAYALPPVDLTPDEATAVAVATQLWESPELVTATQGALLKLRAAGVDVDPVDSEAAVTIASPAGLTGLRGSENVLGILLSAIDSRQAVQFRHRSSRAEPYTTRTVEPWGVVTEKGRWYLVGHDRDRGATRVFRLSRISGEITPIGPAGAIAVPDDVDLRGIVAAKVTEAPTGMRATVWVAGGRATALRRAGQPVGPRRLAGRDGDVIELDIGSSDRLAREIAGYGADAIVLEPAILREDVLARLHAHAGAAR
>NC_022663.1|WP_099184121.1|473238_474597_-|Pup--protein-ligase
MQRRIMGIETEFGVTCTFHGHRRLSPDEVARYLFRRVVSWGRSSNVFLRNGARLYLDVGSHPEYATAECDSLVQLVTHDRAGEWVLEDLLIDAEQRLADEGIGGDIYLFKNNTDSAGNSYGCHENYLIVRAGEFSRISDVLLPFLVTRQLICGAGKVLQTPKAATFCLSQRAEHIWEGVSSATTRSRPIINTRDEPHADAEKYRRLHVIVGDSNMCETTTMLKVGTAALVLEMIEAGVAFRDFSLDNPIRAIREVSHDVTGRRPVRLAGGRQASALDIQREYHARAVDHLQNREPNPQIEQVVDLWGRQLDAVESQDFAKVDTEIDWVIKRKLFQRYQDRYNMELSDPKIAQLDLAYHDIKRGRGVFDLLQRKGLAARVTTDEEIADAVDHPPQTTRARLRGEFISAAQAAGRDFTVDWVHLKLNDQAQRTVLCKDPFRSVDERVKRLIASM
>NC_022663.1|WP_023364674.1|475972_479938_-|non-ribosomal-peptide-synthetase
MAADGVQPLAAAAPPKLVPLSYAQRRLWFIDQLEGPSPIYNMALALRLCGPLDVEALRVAVTDVVGRHRSLRTVFPATDGIPEQRVIDATAADAGWQVTDAVAWPASRLPQAIAALVRYRFDLANQIPLRTELFSVGADEHVLVIVMHHIAADRWSLSPLLRDLATAYTARCAGAVPGWDELTLHYVDYCRWQRDQLGELDDTTSPICAGLAYWQQTLAGLPERLELPADRHYPQVARHEGAGVAVDWPVALRQSVARLAREHRATSFMVITAGVVALLARLSGNTDIAVGIPVAGRTEAAFEEMVGLFVNTVVLRISVAGNPNLTELITRVREASLDAYDHQDVPFEVVVERLNPTRSLTHHPLIQVMLAWQSPAPADELMLPGLCVSSIPADTYAAPLDLTLTFGDRFTPNGAHAGIGGEIIYRTDVFAAPSIERLRDRLERLLTAMTADPSAPLSSIDVLDAAEHAHLDAIGNRAALGKTFAPVSIPELFGAQVARTPRSVALTGVDRRLTYAQLERAANRLAHALIDAGVGPGAVVALLLARSVPATVAIIAVLKTGAAYLPIDTQHPSARIGFMLTDASPKAAITTTDLAPLLVAAGATDLAVIDVDDPRIDTYPSTAPPTPAADHVAYIMYTSGTTGTPKGVAITHRNVTQLFDVVPPFTATAGKAGAQCHSYSFDFSVWEMWGALLHGGRLVVVPDAVARSASDLHALLVREHVDVLTQTPSAIGMLPRRGLESAAVVLLGEVCPVELVDRWAPGRMMINTYGPTEATVWVSTSTPLVADSAPPPIGSPVPGAALFVLDGWLRPVPVGVVGELYVAGAGVGCGYWRRPALTAARFVACPYGVGQRMYRTGDLVRWRADGQLDYLGRADEQVKIRGYRIELGEVSTVLSEVAGGQQAVVIAREDRPGDRRLVGYVAGQLQVEQLRAQLSERLPDYMLPAAVVSVATLPLTVNGKLDKRALPAPDYADTTRYRAPTTAVEETLAGIYAEVLGLPRVGIDESFFDLGGNSLLAMRVVAGVRRSLKVDLPVRSLFDAPSVASLSQLLRRPTRSPEVTPVEVLRHAAGVPLFCIHTAVGLSWPYHALGAYLDCPIVGIQQVVDDDARPDSIRDMAQHYADTVQSLYPGGPYHLLGWSFGGIVVHELAVELRRRGCVVGRLIVLDATPRAEEADDAATAAAREGEILKYVLRANGIELPADDPGPFTYQQAEELIQQRQDANFGLPSAQLLQILITNSIANERYRSEHAPAVFDGDLILFAATRSGNGSTLLEDWRPYVRGHIVEYPVDATHNEMLNAESLRLFGAQLNAALVDGQVSGR
>NC_022663.1|WP_023364675.1|480280_481654_+|MFS-transporter
MVGINRKGFSRGPAIRGGIHRLGAMLLPGSAAGRMLAISAGIDSLGTGLFFASFTLYFVGIVKIGAPQVALASTAAGILALFVPVPLGRLADRLGPGRLYIGLLVLRGLGYCCYAGVSGFKGFLVLTMVLTAADRASTPLQQSVVRALIGNQDGTRTMASIRGVRNVGLTAGFLVAAAAFATAAMSVFTVLFVANGVSFLVAAAMVWPTVSRTEAVAAPAPATAPTAGPTAGAAACPRSPFRDRWFVVFTIGNGVLWLHDSVLIVLLPIWVIKHTAVPAGWVPVFMAVNTVLTAVLQVYVARFANGAVAANRVLGLAGLLLISCCGFLAIGQAAPTAIAVVAVLTAVILLSVAENLHNVAAYELSAELSPEVASSRYLGAFSLAYTGQQVIGPAVMAVLMPVGLIGWPLLAGAFGAAVVVSRGAAGRCLAERAGAASRRPVGAHRFFRGLLSAACPA
>NC_022663.1|WP_023364676.1|481671_482880_-|hypothetical-protein
MSMPGWLIGLREARSPLGADFAPLVFEASAIDLDMLVARLAVLASRHEALRLLWPDLSAAAPETVVDAVAGADTHAGDIGSFAAELALAGYRRAGKPLWRARLVATVQPQQQYVVMGLDRLISDPWSLHVLAQELCMLCQAGPPPDLGPAPAQFGAALAERAGGSDESDARTERLHWRRQLAGANFGADPRVPRAAATTARIRRVPLTVADEHAMVSLASAYRTTLLAPVVAAVHMVWRRQVDAAETVLLTEVGYRGTQALDGTVAPLMEPRPMRIVSDVGAGALISQARGALLDVLDNSCVPLAADPAPMQPFFDHPDRMTVLAEFDTANRPTVHESALNLLDEPSIWAVGPPRADIHVMVRGDHRAPSVYVADNPLAVTGRFADEFAHQLVWALREMSEV
>NC_022663.1|WP_023364677.1|482876_484658_-|alpha/beta-fold-hydrolase
MAGYQRQAAGFGLLCYGPADITDPHRSLLAFPHGGGSPHSFAKLSQELGPGYRVTAVDPPGRPRSRGPVLRELGELVEFYLEHLPAHLLGGVLVGHSVGAYVASALAARLEQQGRPARAVVMSAVVPPAYLDPARPLSKMTDAQRLDWCRTLGTFPVGDKDSAALFALFAEAIRADCEVYESAVCVSLDHTTPLLVLVGEADPACPVQQVAHWPDTHPQAVIRTLPGGGHMLPQDAAHSYAAEVAGFLRHGRNGSIATRPVAGHRRPWRREDMWLRARQGRRCLPVIFPRGRDTPAALHHVLVENDCLETFLTDHGALLARGWNVADARGLQLIVGSTGIEPTPYVGGNSPRTALGNGIYTSTEYPPEAPISPHNEMSYADHWPTRLYFCCQAPAAQGGETLLADGRALVTHPRLEEVVDCMQRKGIRYLRTMHSGSGPGKSWQQTFETADQETVAGLLRDSGAAATWLPGGALRIVECRPAFIHDSNSGRQVWFNQAEQWHHSALPVEIRNALLDEFGEDGLPHNAAYGDGEPIPERHLDAIRHVLEAVSVAHSWRHGDVLVVDNVTTLHGRAPYRGQRRVLVAMTDQVARG

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Crispr_ID: NC_022663_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022663_2

536998-537106

Unclear

Consensus_repeat	Method
AGCCCGGCGACTCAAACGTTACGAGCGGCCCGCGCAGCGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022663_2

>merge|NC_022663|2|536998-537106|CRISPRCasFinder
AGCCCGGCGACTCAAACGTTACGAGCGGCCCGCGCAGCGGGCCGTTGAGGAGCCGGGCAATCAGACCCAGCCCGGCGACTCAAACGTTACGAGCGGCCCGCGCAGCGGG

>NC_022663|2|2|536998-537106|CRISPRCasFinder
AGCCCGGCGACTCAAACGTTACGAGCGGCCCGCGCAGCGGG	CCGTTGAGGAGCCGGGCAATCAGACCC
AGCCCGGCGACTCAAACGTTACGAGCGGCCCGCGCAGCGGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_022663.1\|WP_023364701.1\|521950_522232_-\|phosphoribosyl-ATP-diphosphatase	unknown	unknown	gnl\|CDD\|212154
NC_022663.1\|WP_023364711.1\|537405_538194_-\|3'(2'),5'-bisphosphate-nucleotidase-CysQ	unknown	unknown	gnl\|CDD\|224139
NC_022663.1\|WP_023364716.1\|541764_542067_-\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_023364709.1\|534821_535715_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235633
NC_022663.1\|WP_036393185.1\|523540_525028_+\|arylsulfatase	unknown	unknown	gnl\|CDD\|293761
NC_022663.1\|WP_023364715.1\|540872_541703_-\|undecaprenyl-diphosphate-phosphatase	unknown	unknown	gnl\|CDD\|237134
NC_022663.1\|WP_023364710.1\|535739_536984_-\|cysteine--1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside-ligase	unknown	unknown	gnl\|CDD\|183518
NC_022663.1\|WP_023364706.1\|529065_532644_-\|methionine-synthase	unknown	unknown	gnl\|CDD\|273959
NC_022663.1\|WP_042313224.1\|532763_533618_+\|PAC2-family-protein	unknown	unknown	gnl\|CDD\|378251
NC_022663.1\|WP_023364713.1\|539497_540085_-\|DUF3090-domain-containing-protein	unknown	unknown	gnl\|CDD\|213872
NC_022663.1\|WP_051404563.1\|543525_544608_+\|quinone-dependent-dihydroorotate-dehydrogenase	unknown	unknown	gnl\|CDD\|235388
NC_022663.1\|WP_099184126.1\|542243_543239_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|271320
NC_022663.1\|WP_023364704.1\|525047_527402_+\|sulfatase-like-hydrolase/transferase	unknown	unknown	gnl\|CDD\|293749
NC_022663.1\|WP_023364720.1\|544674_550506_-\|PE-family-protein	unknown	unknown	gnl\|CDD\|376422
NC_022663.1\|WP_023364714.1\|540147_540876_-\|MSMEG_4193-family-putative-phosphomutase	unknown	unknown	gnl\|CDD\|163560
NC_022663.1\|WP_036393187.1\|522403_523246_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NC_022663.1\|WP_080674189.1\|533614_534793_-\|FAD-dependent-monooxygenase	unknown	unknown	gnl\|CDD\|169028
NC_022663.1\|WP_023364712.1\|538698_539514_-\|SCO1664-family-protein	unknown	unknown	gnl\|CDD\|274813
NC_022663.1\|WP_042311690.1\|543292_543499_+\|dihydroorotate-dehydrogenase	unknown	unknown	unknown
NC_022663.1\|WP_042313221.1\|527500_528748_-\|PPE-family-protein	unknown	unknown	gnl\|CDD\|366325

Protein	Function_ID	Function_description	E-value
NC_022663.1\|WP_023364701.1\|521950_522232_-\|phosphoribosyl-ATP-diphosphatase	gnl\|CDD\|212154	cd11547, NTP-PPase_HisE, Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs. This family includes M. tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs. M. tuberculosis HisE is encoded by the hisE gene, which is a separate gene presenting in many bacteria and archaea but is fused to hisI in other bacteria, fungi and plants. HisE is responsible for the second step in the histidine-biosynthetic pathway. It can irreversibly hydrolyze phosphoribosyl-ATP (PRATP) to phosphoribosyl-AMP (PRAMP) and pyrophosphate. HisE dimerizes into a four alpha-helix bundle, forming two inferred PRATP active sites on the outer faces. M. tuberculosis HisE has been found to be essential for growth in vitro, thus making it a potential drug target for tuberculosis.	2.30197e-44
NC_022663.1\|WP_023364711.1\|537405_538194_-\|3'(2'),5'-bisphosphate-nucleotidase-CysQ	gnl\|CDD\|224139	COG1218, CysQ, 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase [Inorganic ion transport and metabolism].	3.14032e-77
NC_022663.1\|WP_023364709.1\|534821_535715_-\|SDR-family-oxidoreductase	gnl\|CDD\|235633	PRK05872, PRK05872, short chain dehydrogenase; Provisional.	5.87161e-158
NC_022663.1\|WP_036393185.1\|523540_525028_+\|arylsulfatase	gnl\|CDD\|293761	cd16142, ARS_like, uncharacterized arylsulfatase subfamily. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.	6.08173e-175
NC_022663.1\|WP_023364715.1\|540872_541703_-\|undecaprenyl-diphosphate-phosphatase	gnl\|CDD\|237134	PRK12554, PRK12554, undecaprenyl pyrophosphate phosphatase; Reviewed.	2.70981e-109
NC_022663.1\|WP_023364710.1\|535739_536984_-\|cysteine--1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside-ligase	gnl\|CDD\|183518	PRK12418, PRK12418, cysteinyl-tRNA synthetase; Provisional.	0
NC_022663.1\|WP_023364706.1\|529065_532644_-\|methionine-synthase	gnl\|CDD\|273959	TIGR02082, Methionine_synthase, 5-methyltetrahydrofolate--homocysteine methyltransferase. This family represents 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13), one of at least three different enzymes able to convert homocysteine to methionine by transferring a methyl group on to the sulfur atom. It is also called the vitamin B12(or cobalamine)-dependent methionine synthase. Other methionine synthases include 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase (MetE, EC 2.1.1.14, the cobalamin-independent methionine synthase) and betaine-homocysteine methyltransferase. [Amino acid biosynthesis, Aspartate family].	0
NC_022663.1\|WP_042313224.1\|532763_533618_+\|PAC2-family-protein	gnl\|CDD\|378251	pfam09754, PAC2, PAC2 family. This PAC2 (Proteasome assembly chaperone) family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 247 and 307 amino acids in length. These proteins function as a chaperone for the 26S proteasome. The 26S proteasome mediates ubiquitin-dependent proteolysis in eukaryotic cells. A number of studies including very recent ones have revealed that assembly of its 20S catalytic core particle is an ordered process that involves several conserved proteasome assembly chaperones (PACs). Two heterodimeric chaperones, PAC1-PAC2 and PAC3-PAC4, promote the assembly of rings composed of seven alpha subunits.	5.13956e-54
NC_022663.1\|WP_023364713.1\|539497_540085_-\|DUF3090-domain-containing-protein	gnl\|CDD\|213872	TIGR03847, TIGR03847, conserved hypothetical protein. The conserved hypothetical protein described here occurs as part of the trio of uncharacterized proteins common in the Actinobacteria.	2.13336e-87
NC_022663.1\|WP_051404563.1\|543525_544608_+\|quinone-dependent-dihydroorotate-dehydrogenase	gnl\|CDD\|235388	PRK05286, PRK05286, quinone-dependent dihydroorotate dehydrogenase.	0
NC_022663.1\|WP_099184126.1\|542243_543239_+\|hypothetical-protein	gnl\|CDD\|271320	cd05819, NHL, NHL repeat unit of beta-propeller proteins. The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.	0.000115767
NC_022663.1\|WP_023364704.1\|525047_527402_+\|sulfatase-like-hydrolase/transferase	gnl\|CDD\|293749	cd16025, PAS_like, Bacterial Arylsulfatase of Pseudomonas aeruginosa and related proteins. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.	0
NC_022663.1\|WP_023364720.1\|544674_550506_-\|PE-family-protein	gnl\|CDD\|376422	pfam00934, PE, PE family. This family named after a PE motif near to the amino terminus of the domain. The PE family of proteins all contain an amino-terminal region of about 110 amino acids. The carboxyl terminus of this family are variable and fall into several classes. The largest class of PE proteins is the highly repetitive PGRS class which have a high glycine content. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	3.6567e-26
NC_022663.1\|WP_023364714.1\|540147_540876_-\|MSMEG_4193-family-putative-phosphomutase	gnl\|CDD\|163560	TIGR03848, MSMEG_4193, probable phosphomutase, MSMEG_4193 family. A three-gene system broadly conserved among the Actinobacteria includes MSMEG_4193 and homologs, a subgroup among the larger phosphoglycerate mutase family protein (pfam00300). Another member of the trio is a probable kinase, related to phosphatidylinositol kinases; that context supports the hypothesis that this protein acts as a phosphomutase.	4.17924e-121
NC_022663.1\|WP_036393187.1\|522403_523246_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	6.94077e-12
NC_022663.1\|WP_080674189.1\|533614_534793_-\|FAD-dependent-monooxygenase	gnl\|CDD\|169028	PRK07588, PRK07588, FAD-binding domain.	1.27258e-73
NC_022663.1\|WP_023364712.1\|538698_539514_-\|SCO1664-family-protein	gnl\|CDD\|274813	TIGR03843, Phosphatidylinositol_3-_and_4-kinase, conserved hypothetical protein. This model represents a protein family largely restricted to the Actinobacteria (high-GC Gram-positives), although it is also found in the Chloroflexi. Distant similarity to the phosphatidylinositol 3- and 4-kinase is suggested by the matching of some members to pfam00454.	8.0075e-130
NC_022663.1\|WP_042313221.1\|527500_528748_-\|PPE-family-protein	gnl\|CDD\|366325	pfam00823, PPE, PPE family. This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	1.04013e-55

>NC_022663.1|WP_023364710.1|535739_536984_-|cysteine--1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside-ligase
MRSWSSAPVPNLPGRGPELRLYDTADRQVRPVTPGPKATMYVCGITPYDATHLGHAATYLAFDLIHRLWLDLGHDVQYVQNVTDVDDPLFERADRDGVDWRELADREVKLFRADMEALRVLPPHDYVAATEAVAEMVELIEKMLASGAAYTVDPEIGDYPDIYYRADATVQFGYESGCDRDTMLTLFEQRGGDPSRPGKTDQLDALLWRAARAGEPSWPSPFGPGRPGWHVECAAIALSRINSGLDIQGGGSDLIFPHHEFTAAHAECVTGERRFARHYVHAGMIGWDGHKMSKSRGNLVLVSTLRAQGVEPSAVRLGLLAGHYREDRFWTHQVLDEAAGRLQRWRTATALPAGPDAADVIARVRRYLADDLDTPKAIAALDGWATDALEYGGHDESAPTSVATAIDALLGVDL
>NC_022663.1|WP_023364709.1|534821_535715_-|SDR-family-oxidoreductase
MTSVQDKVVFITGGARGIGAEVARRLHNKGAKLVLTDIGTAELTTIAAELGGDGRVLTVVADVRDLSAMQAAADLAIEKFGGIDVVIANAGIASYGSVLQVDPEAFKRVLDVNVLGVFHTVRATLPAVIERRGYVLIVSSLAAFAASPGLAPYNATKAGVEIFANALRLEVAHHGVSVGSAHMSWIDTALVRDTKADLPAFDELLRRLPWPLNLTTSVNKCAAAFVKGIEGRKTRIFCPRWVGLFRWLKPVLSTSVGERPIRKITAELLPRMDAEAAALGRSTSAYTHALDNASEKQ
>NC_022663.1|WP_080674189.1|533614_534793_-|FAD-dependent-monooxygenase
MAICGAGTAGLSLAERLSALGAEVVVLERSSGPRTHGHMIDFYGAGYDAAEAIGVLPAIQRVGYPLGDSSLIDRHGRRRAALPYRQIARALDGRLCRVMRPDLEKVLLDNLPPQVELRFGATVSDVAQRDDRVTVTLQRGAQLDADLLVGADGIHSTVRTLVFGVEPQYLRYPGFRSASFVLDAPGVRGSAAEHVVFTDTADRQLGLHLLRDGRTAVTAVYRTVDASPPHDVRAALREEYAGMGGLVAEVLDRCPEDGAVEYDQVAQIQMPRWSSKRVVLIGDASFAVSALSRQGASLAVASAYVLSEQLRKTSSVERALAFYERLWRPVVEDKQQSGQAASGWLWPGPSQSAIRRAMLRLSWRPLVNRFIEATLAGEPTALITMLRLGSGD
>NC_022663.1|WP_042313224.1|532763_533618_+|PAC2-family-protein
MLPELHNTVVVAAFEGWNDAGDAASDAVSHLADIWDARPIVEIDDEAYYDYQVNRPVIRQVDGVTRELEWPAMRISHCRPPGSDRDVVLMHGVEPNMRWRTFCAELLAIVDKLNVDTVVILGALLADTPHTRPVPVSGAAYSPESAQIFGLQETRYEGPTGIAGVFQYACVAAGIPAVTFWAAVPHYVSHPPNPKATVALLRRVEDVLDVEVPLGDLPTQAEAWAQEISEMAAEDDELAEYVQSLEQHGDAAVDVNDVLGTIDGDALAAEFERYLRRRRPGFGR
>NC_022663.1|WP_023364706.1|529065_532644_-|methionine-synthase
MTAANKPRYDTDLLDVLAQRVVVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVLETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADKIRDLSEKGTTIARRVADELSTPERKRYVLGSMGPGTKLPTLGHTDYAVIRDAYTEAALGMLDGGADSILVETCQDLLQLKAAVLGSRRAMKQAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSEHLRYLSRHARIPVSVMPNAGLPVLGAKGAEYPLRPDELAEALSGFIAEFGLSLVGGCCGTTPAHIREVAAAVVGAPRPERQVSFEPSVSSLYSAVPFAQDASVLVIGERTNANGSKGFREAMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDSTETPVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMELVAEHGAAVVALTIDEEGQARTAEKKVEIAERLINDITTNWGVDESSILIDTLTFTIATGQEESRKDGIETIEAIRELKKRHPDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRTVALDLVYDRRRDGYDPLQELMRLFEGVSAASSKESRAAELAKLPLFERLAQRIVDGERNGLEADLDEAMTQKPPLEIINENLLAGMKTVGELFGSGQMQLPFVLQSAEVMKTAVAYLEPHMEKSDDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKSADVVGMSGLLVKSTVVMKENLEEMNSRGVAEKFPVLLGGAALTRSYVENDLADIYEGEVHYARDAFEGLKLMDTIMSSKRGEAPDVDSPEAIQARKKEAERKARHERSKRIAAQRKAAEEPVEIPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGMLDERALFLGQWGLRGQRGADGPSYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGDEVVVLTEPAADAEERYRFRFPRQQRGRFLCIADFVRSREHARERGQVDVLPFQLVTMGQPIADFANELFAADSYRDYLEVHGIGVQLTEALAEYWHRRIREELRYSADRTMAAEDPDAVEDYFKLGYRGARFAFGYGACPDLEDRAKMMQLLEPDRIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV
>NC_022663.1|WP_042313221.1|527500_528748_-|PPE-family-protein
MSAPVWMAFPPEVHSALLSAGPGPASLIAAAQAWSSLSAEYGAVADELAPVVAALRTEAWRGTAAECCVAAYVPYLAWVMQESADCAQVAAVHEITAAAYQAALAAMPTLGELAANHATHAVLLATNFFGVNAIPIAFNEADYARMWMQAATIMNVYETTSSPAVASTPHTPPAPAIIKPGAGLVNAIETTITPFPIWQILQILLDAVVGVLHCIRESLVATVLALLFIPLCVLLAVIALLTGHVAMAEQFLGFIVNLAIIPFQFFLEAGWIFIVGLADICELVIAWFLGNLGFVGGPGLVTQLATTTALSGGAALGVGALKGTTVALELAPASFAAMAVGADGSLATAGSAVSPAELGGPVGFAGTITNGTVPQAGGLTTLSGHTCCDGVQVPMLPSGWAQHVCGDDSTSWVLG
>NC_022663.1|WP_023364704.1|525047_527402_+|sulfatase-like-hydrolase/transferase
MAITEYRPGTTFPGVIGRTADESTPAWPALKRPAEGAPNVVFIVLDDTGYGHLGCFGSPISTPNIDALAADGLRYSNMHTTALCSPSRSCILNGRNHHSNHLACLTNGSTGFPGSDGYIPFENGFLSEILRAQGYNTYCVGKWHLAPEETMTAAGPYDRWPLGRGFERYYGFLGGDTHQYYPDLVRDNSQTEPEATPEQGYHLTPDLVNKAKAMIADAKQVAPDKPFFLYFAPGATHSPHHVPKQWADRYAGKFDAGWEAYRQRVFTRQRELGLLPATAELSAPDPDVADWETLPADERRLYARMMEVFAGFLEHTDHYIGELVQFLKDLHEYDNTVIMLVSDNGASAEGGPTGSVTEVRFFNNVADTVEEGLARIDEIGGPTVFNHFPWGWTHAGNTPFRRWKRETYRGGSSDPLIVTWPRGIAARGEVRSQYAHLIDMVPTVLEALRIDPPTSIGGVTQSPIEGVSFAHTFDDAAAPTRHLTQYFEMLGHRSIYHDGWRAVCPWPGTSFAESTHKFGDVITAEMLSQLDESGWELYHVAQDPAETTNLAGQERARLIAMITLWYSEAGRYNVLPIDSRGLARAFVERPQIAGANRTRYVLYPGTQAIPAAAAPKILNRPYSINAEVELTEESSGVLLSMGGNDGGITLYVKDGQLCYAHNYVAKEIFTIRSEQRVPPGRHFLSVEFTPTGPVDLKNGRGTPGDVTLFVDGAAVGRGEFPVTTPLRLAQGGAMLVGANTGSSVTPDYDPPFAFDGRIHRVIVDVSGEHVEDYQAQMKIALTKQ
>NC_022663.1|WP_036393185.1|523540_525028_+|arylsulfatase
MAAETADAAARPNILVIWGDDVGMWNISAYHRGMMGGSTPNIDRIANEGMIFMDHYAQASCTAGRAAFITGQYPIRVGLSTVGLPGSDIGLQKEDPTLAEMVKPLGYTTGQFGKNHLGDRDEHLPTLHGFDEFFGILYHLNAGEYAEQYDFPTNPEIVEKFGFGQRGALHCWANPDGTQRIEDTGPYGRERQRTLDREFLTETKRFIRDAAAAETPFFVWHNSTRMHYRTNLAPEYDGKSGYGVYADGMMELDDHVGELLDLLDELGIADNTLVMWSTDNGAACNSWPDGGNHPFAREKGVGGYEGAFRVPALVRWPGVIPAGVASGEFMAMEDWIPTIMSMLGQPDLADSLKKGATIGGREYRVHLDGVDQTDLLTGRGKSKRMEFYYFTETSLHGLRYGDWKVLLKTQDRWFNGIQQKLTTPLITNLKLDPFERFHKARGFDEWQENHAWLYGPAALQVMRFLATLHEFPPRMRSFGIDVDELLNQLNPARHR
>NC_022663.1|WP_036393187.1|522403_523246_+|alpha/beta-hydrolase
MRRDIQWTTSGLRLRRRASRAGDLNWLFLPGGPGIGSESLHELVDTVDVPGCSWMVDLPGDGSNVNAPGAPADPYDLWPQVLLEAAHAVAHPVFVGHSTGGEYLLSVPALDGCLAGLALVSTAPDASWIPVFEHMTRNNRLPGVEYATTRYLSDPTDDHLRRVAVESAPWNFAAHTVARGTEILARLPYNARAAQWSEANFDRGYRSAWWPSTLPTLIVSGSADRIVTQTLWHDKRFHTPNTTWRVIAGAGHFPWIEQPAAVHDAFAALVGQIDNRRTTD
>NC_022663.1|WP_023364701.1|521950_522232_-|phosphoribosyl-ATP-diphosphatase
MKQSLAVKTFEDLFAELGDRARTRPAGSATVAALDAGVHWLGKKILEEAGEVWLAAEHEANDALAEEISQLLYWTQVLMISRGLSLDDVYRKL
>NC_022663.1|WP_023364711.1|537405_538194_-|3'(2'),5'-bisphosphate-nucleotidase-CysQ
MSPAADDLTDAQLAADLAAEAGELLLALRDEVGFDHPWALGDAGDARANSLLVRRLRAARPGDAVLSEEAHDDLVRLKCDRVWIIDPLDGTREFSTRGRDDWAVHVALWQRTTNGRPQITDAAVSLPARGNIVYRSDTVTADAAPTGIPDVIRVAVSANRPPAILHYIQQTVDIELVRIGSAGAKAMAVIDGYADAYLHAGGQWEWDSAAPAGVVLAAGMHASRLDGSPLQYNQLDPYLPDFLMCRKELAPVLLGAMRRTWR
>NC_022663.1|WP_023364712.1|538698_539514_-|SCO1664-family-protein
MNPSNDECEVLRHGELTVLGRIRSASNATFLCESTLGGKTVHCVYKPVAGEQPLWDFPDGTLAGRELSAYLVSASLGWNIVPYTVIRDGPAGPGMLQLWVRQPGDSLDAEARPGPDLVDLFPTGKARPGYLPVLRAYDYAGDEVVLMHADDDQLRRMAVFDVLVNNADRKGGHILCGIDGRVYGVDHGVCMHVQDKLRTVLWGWAGKPIDEPTLEPIARLADDLRGSLADELRDHVTSAEIAALRRRVRALLDNPVMPGPNRHRPIPWPAF
>NC_022663.1|WP_023364713.1|539497_540085_-|DUF3090-domain-containing-protein
MARAIHVFRTPDRFVAGTVGQPGNRTFYIQAAHDDRVVSVVLEKQQVAVLAERIGALLLEVNRRFGTPVPPEPAEVEDLNPLIMPVDAEFRVGTMGLGWDSEAQTVVVELLAVTDAEFDASVVLDDTDEGPDAVRVFLTPESARQFATRSNRVISAGRPPCPLCQEPLDPQGHICARTNGYRRDLLFGSDDEPEQ
>NC_022663.1|WP_023364714.1|540147_540876_-|MSMEG_4193-family-putative-phosphomutase
MTVILLRHGRSTSNTAGILAGRSEGVGLDDKGREQATGLIDRFGDLPVRAVVASPLLRCRATVEPLADALCLEPLVDDRLAEVDYGDWTGRKIAELTNEPLWRVVQAHPSAAVFPGGEGLAQVQARAVTAVREHDRRLALEYGGDVLWLACTHGDVIKAVIADAYGMHLDSFQRITADPASASVIRYTELRPFVLHVNHTGARLSAGLRAAPPPKAEPGGEQPAAPDAEVPSGDAVVGGSTD
>NC_022663.1|WP_023364715.1|540872_541703_-|undecaprenyl-diphosphate-phosphatase
MSWWQVISLAVVQGLTEFLPVSSSGHLAIMSRIFFSDDAGASFTAVTQLGTEAAVLVYFARDIVRILRAWVDGLVVKSHRNADYRLGWYVIIGTIPICILGLFFKDEIRSGVRNLWVVATAMVVFSGVIALAEYLGRQGRQVEQLNWRDAVVVGIAQTLALVPGVSRSGSTISAGLFLGLDRELAARFGFLLAIPAVFASGLFSLPDAFHPVTEGMSATGPQLLVATLIAFVVGLSAVAWFLHFLLRHNMYWFVGYRIVVGVGVLVLLATGTVSAT
>NC_022663.1|WP_023364716.1|541764_542067_-|hypothetical-protein
MTVTADRHVANKQFAIEDMSTGIFASGYGQVGDGRSFSFHIEHRSLVVEIYRPRLTAPVPQAEDVVARSVRSLVDIDVTDERSLAAAVRDSVAQAVPVSR
>NC_022663.1|WP_099184126.1|542243_543239_+|hypothetical-protein
MLTLVTACSSNPLHTAPPTIQPAQPAVSPPVSQAPAGVIRPLSGHPQAALYDNGARRLVVLTPDADPSAPSGITVFDDAQTPSRVITLPGPATALTCDDHGTAYLAARGGYLVVDLSAGRIAQVSVADAAGTDFTAIARRADGKLVLGSADGAVYILDSESSGTARTANRIKIFARVDSLVTQGNTTVVLDRGQTSVTTIGADGRARQALRAGEGATTLAADPLGRVLVADTRGGQLLVYGVDPLILRQAYPVPQAPYGLAGSRELAWVSQTASNVVIGYDLSTGIPVEKVRYPTVQQPNSLAFDDASGTLYVVSGSGAGVQVIEHAAGIA
>NC_022663.1|WP_042311690.1|543292_543499_+|dihydroorotate-dehydrogenase
MSDEYEWAPLRLPPEVTRLSASTRLSIEAEYRGWELTRVRLYTDGSRRVLLRRKKSRLDNASSDQPEP
>NC_022663.1|WP_051404563.1|543525_544608_+|quinone-dependent-dihydroorotate-dehydrogenase
MYSLVRRLLFLLPPERAHTFVFALLRAVTAVAPARRMLSRWLGPTDPVLASTVFGVRFPGPLGLAAGFDKDGTGLDTWGALGFGYAEVGTVTARPQPGNPPPRMFRLPADRALLNRMGFNNHGAGALAIRLTRHRPRVPIGVNIGKSKATPAGEAVDDYRASARLVGPLAAYLVVNVSSPNTPGLRDLQAVESLRPILTAVLAETSTPVLVKIAPDLSDSDIDDIADLAVELGLAGIVATNTTVSRDGLATPGVDELGAGGISGPPVAARAVQVLRRLQHRVGDRLVLISVGGIETVDDAWERITAGATLLQGYTGFIYGGGLWAKHIHDGIARRLHDGGFASLADAVGSAARKAGKPPG
>NC_022663.1|WP_023364720.1|544674_550506_-|PE-family-protein
MSFVLASPEVLAAAAADVVRIGSVLRSANAAAATPTIAVSAPGADEVSAAVASLFAGHGQAYQRLSAHLTAYHDQFVRTLQSSADAYAGAEAANAAPLQSAGQGLLNLINAPTEALLGRPLVGNGADGASGPVGQPGQSGGILYGDGGNGGNSGAPGAAGGAGGSAGLIGNGGAGGTGGAGAAGGTGGRGGWWAGSGGAGGLGGVGGGDGGHGGYAPLFGNGGQGGAGGSDAGGNGGHGGTGGRGGVVFGSGGSGGAGGAGGVAGGAGGDGGNAALIGLGGAGGAGGDGTSGMAGVAGGAGGAGGTGGNGGVFGFGGHGGAGGDGGAGGAGEAALAGQQGGMGASGGAAGAGGAGGRAIIGLAGDGGHGGSGGAGGIGGAGGNAVTLGAQGGQGGTGGTGGAAGAGGAAGGFGGSAGSTGKGGVGGHGGTGGTGGAGQAGASDPSAPTAGLQGGQGGDGGLGGAGGAGVGGVGGGAGGQGGVGGAGGHGGAGGANTGSSAGSGAAGGQGGTGGAAGAGGSGTDGGAAGATGTGGQGGTGGTGGRGASGLAGTSGVSPTGGGQGGQGGDGGQGGAGGAGIGGIGGGAGGQGGVGGHGGAGGTGGANTGNSGGSGADGGQGGIGGAAGAAGSGTDGGAAGAAGTGGQGGAGGTGGAGGTGAPAATRSDTGAAGGHGGNGGAGGQGGAGNGGINGSGGAGGDGGHGGQGGTGYADDGTNGATAGGTGGTGGTGGTGGAAGTGGAGGSAGAAGDGGDGGRGGQGGVSTTLGDTAGQGGQGGQGGQGGQGALGPASGVGHTGGQGGQGGQGGQGGNAANGANNGAGGRGGDGGAGGTGGSGYHDDGADNAGTGGTGGAGGQGGAGGTTGTGGLPGQNVGQGGHGGAGGQGGQGGATTIGGHTAGDGGQGGQGGQGGDGANGVRPNVANTGGLGGQGGAGGQGGDGGSAVAGATNGSGGHGGQGGRGGTGGAGYNDDGGYDATDGGAGGTGGQGGAGGAAGMGGTGGAAGAAGTGGTGGSGGDGGAGKAARASGSPFDGGWGAAGGAGGQGGAGGAGVGGVGGGQGGQGGVGGHGGAGGAGGNNTGTSSGTGGAGGQGGTGGAAGAGGAGADGGAAGANGTAGDGGDGGAGGKGGAGQSGASGTSPTDGSPGGQGGAGGQGGAGGAGIAGVGGGQGGQGGAGGQGGVGGAGGTNTGTSGGDGANGGQGGVGGAAGAGGSATDGGAIGANGAGGKGGAGGAGGNGGGGQAGTSGASPTAGGQGGTGGTGGRGGDGGAGIGGVGGGQGGQGGAGGQGGVGGTGGTDTGTSGGDGADGGKGGTGGLSGSGGSGTDGGLNGADGIGGKGGTGGAGGNGGTGQAGTSGSVPTVGETGGRGGAGGQGGDGGAAPGNIFGGQGGQGGVGGQGGAGGAGGTNTGASGGSGADGGQGGAGGAAGAGGVGSGNGAHGAIGTGGRGGTGGAGGNGGTGQAGTSGSVPTAGGQGGGGGAGGQGGAGGAGIGGVGGGQGGQGGLGGNGGTGGAGGTNTGTGIDAAGANGGKGGTGGAAGAAGSGTDGGAAGAIGAGGKGGAGGTGGNGGSGQAGSSGTTPTAGGQGGRGGAGGQGGDGGAGIGGVGGGQGGQGGIGGQGGTGGAGGNNTGTGLNAAGADGGKGGTGGVAGAAGSGTDGGAAGAVGTGGKGGTGGAGGAGGAGQAGTSSPSPTAGGQGGAGGRGGQGGDGGAGIIGGIGGGQGGTGGAGGQGGTGGAGGNNTSSSTANGAAGGRGGSGGTAGTGGVGGDGGGTGGIGGQGGAGGTGGTGGSGSVSGTGGGGGAGGTAGTGGVGGAGASNGIGNAGNGGTGGTGGTGGTGGHGGFGNGTKNSAGAGGKGGDAAVGGVGGVGGNAVIGVGGTGGTGGTGGNGGTGGDGGGGFGSVGTSGGGGSAGAAPLGSTGGAGGGGGSAGTGGAGAPARSPF

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Crispr_ID: NC_022663_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022663_3

1067667-1067735

Orphan

Consensus_repeat	Method
CCGATATTGCCGCTGCCCACGTT	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NC_022663_3

>merge|NC_022663|3|1067667-1067735|CRISPRCasFinder
CCGGTGTTGACGTTGCCCGAGTTACCGAAGCTGGTGTTCGAGTTGCCGGCATTGAAGCTGCCCGCGTTG

>NC_022663|3|3|1067667-1067735|CRISPRCasFinder
CCGGTGTTGACGTTGCCCGAGTT	ACCGAAGCTGGTGTTCGAGTTG
CCGGCATTGAAGCTGCCCGCGTTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_022663.1\|WP_036393197.1\|1063888_1065073_-\|PPE-family-protein	unknown	unknown	gnl\|CDD\|366325
NC_022663.1\|WP_041803325.1\|1065493_1066669_-\|PPE-family-protein	unknown	unknown	gnl\|CDD\|366325
NC_022663.1\|WP_036393202.1\|1057005_1058532_-\|phospholipase-C	unknown	unknown	gnl\|CDD\|226042
NC_022663.1\|WP_023365625.1\|1073525_1073918_+\|transcriptional-repressor	unknown	unknown	gnl\|CDD\|223806
NC_022663.1\|WP_036393041.1\|1056387_1056645_-\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_036392645.1\|1075330_1076128_-\|DNA-repair-protein-RecO	unknown	unknown	gnl\|CDD\|234622
NC_022663.1\|WP_178131770.1\|1060671_1062231_-\|phospholipase-C	unknown	unknown	gnl\|CDD\|226042
NC_022663.1\|WP_036393043.1\|1055943_1056240_-\|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl\|CDD\|377587
NC_022663.1\|WP_023365606.1\|1058924_1060457_-\|phospholipase-C	unknown	unknown	gnl\|CDD\|226042
NC_022663.1\|WP_023365598.1\|1053415_1055425_+\|TPM-domain-containing-protein	unknown	unknown	gnl\|CDD\|377378
NC_022663.1\|WP_023365627.1\|1073995_1074445_-\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_023365619.1\|1069349_1071242_-\|PPE-family-protein	unknown	unknown	gnl\|CDD\|366325
NC_022663.1\|WP_023365623.1\|1073136_1073529_+\|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|197713
NC_022663.1\|WP_036392642.1\|1076189_1077698_+\|amidase	unknown	unknown	gnl\|CDD\|235686
NC_022663.1\|WP_023365635.1\|1077724_1078636_-\|GTPase-Era	unknown	unknown	gnl\|CDD\|234624
NC_022663.1\|WP_023363993.1\|1055620_1055905_-\|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl\|CDD\|377587
NC_022663.1\|WP_036393017.1\|1078632_1078953_-\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_023365621.1\|1071550_1072945_-\|glycine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235240
NC_022663.1\|WP_023365611.1\|1062807_1063596_+\|GAP-family-protein	unknown	unknown	gnl\|CDD\|378566
NC_022663.1\|WP_036392649.1\|1074444_1075338_-\|decaprenyl-diphosphate-synthase	unknown	unknown	gnl\|CDD\|173288

Protein	Function_ID	Function_description	E-value
NC_022663.1\|WP_036393197.1\|1063888_1065073_-\|PPE-family-protein	gnl\|CDD\|366325	pfam00823, PPE, PPE family. This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	9.63058e-51
NC_022663.1\|WP_041803325.1\|1065493_1066669_-\|PPE-family-protein	gnl\|CDD\|366325	pfam00823, PPE, PPE family. This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	1.02174e-51
NC_022663.1\|WP_036393202.1\|1057005_1058532_-\|phospholipase-C	gnl\|CDD\|226042	COG3511, PlcC, Phospholipase C [Cell envelope biogenesis, outer membrane].	0
NC_022663.1\|WP_023365625.1\|1073525_1073918_+\|transcriptional-repressor	gnl\|CDD\|223806	COG0735, Fur, Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism].	8.06071e-47
NC_022663.1\|WP_023365621.1\|1071550_1072945_-\|glycine--tRNA-ligase	gnl\|CDD\|235240	PRK04173, PRK04173, glycyl-tRNA synthetase; Provisional.	0
NC_022663.1\|WP_036392645.1\|1075330_1076128_-\|DNA-repair-protein-RecO	gnl\|CDD\|234622	PRK00085, recO, DNA repair protein RecO; Reviewed.	6.40078e-88
NC_022663.1\|WP_178131770.1\|1060671_1062231_-\|phospholipase-C	gnl\|CDD\|226042	COG3511, PlcC, Phospholipase C [Cell envelope biogenesis, outer membrane].	0
NC_022663.1\|WP_036393043.1\|1055943_1056240_-\|WXG100-family-type-VII-secretion-target	gnl\|CDD\|377587	pfam06013, WXG100, Proteins of 100 residues with WXG. ESAT-6 is a small protein appears to be of fundamental importance in virulence and protective immunity in Mycobacterium tuberculosis. homologs have been detected in other Gram-positive bacterial species. It may represent a novel secretion system potentially driven by the pfam01580 domains in the YukA-like proteins.	3.26736e-11
NC_022663.1\|WP_023365606.1\|1058924_1060457_-\|phospholipase-C	gnl\|CDD\|226042	COG3511, PlcC, Phospholipase C [Cell envelope biogenesis, outer membrane].	0
NC_022663.1\|WP_023365598.1\|1053415_1055425_+\|TPM-domain-containing-protein	gnl\|CDD\|377378	pfam04536, TPM_phosphatase, TPM domain. This family was first named TPM domain after its founding proteins: TLP18.3, Psb32 and MOLO-1. In Arabidopsis, this domain is called the thylakoid acid phosphatase -TAP - domain and has a Rossmann-like fold. In plants, the family resides in the thylakoid lumen attached to the outer membrane of the chloroplast/plastid. It is active in the photosystem II.	1.67335e-20
NC_022663.1\|WP_023365619.1\|1069349_1071242_-\|PPE-family-protein	gnl\|CDD\|366325	pfam00823, PPE, PPE family. This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	4.16089e-74
NC_022663.1\|WP_023365623.1\|1073136_1073529_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197713	smart00418, HTH_ARSR, helix_turn_helix, Arsenical Resistance Operon Repressor.	1.22235e-18
NC_022663.1\|WP_036392642.1\|1076189_1077698_+\|amidase	gnl\|CDD\|235686	PRK06061, PRK06061, amidase; Provisional.	0
NC_022663.1\|WP_023365635.1\|1077724_1078636_-\|GTPase-Era	gnl\|CDD\|234624	PRK00089, era, GTPase Era; Reviewed.	3.57123e-165
NC_022663.1\|WP_023363993.1\|1055620_1055905_-\|WXG100-family-type-VII-secretion-target	gnl\|CDD\|377587	pfam06013, WXG100, Proteins of 100 residues with WXG. ESAT-6 is a small protein appears to be of fundamental importance in virulence and protective immunity in Mycobacterium tuberculosis. homologs have been detected in other Gram-positive bacterial species. It may represent a novel secretion system potentially driven by the pfam01580 domains in the YukA-like proteins.	5.70515e-10
NC_022663.1\|WP_023365611.1\|1062807_1063596_+\|GAP-family-protein	gnl\|CDD\|378566	pfam11139, SfLAP, Sap, sulfolipid-1-addressing protein. SAP is a transmembrane transport protein with six predicted transmembrane helices, with a hydrophilic domain between helices 3 and 4. This hyrodphobic region is highly variable among identified Gap-like (GPL, peptidoglycolipid, addressing protein) proteins and may be involved in substrate recognition. SAP also belongs to the LysE protein superfamily (pfam01810), whose members have been implicated in small molecule transport in bacteria. Other Gap proteins export metabolites across the cell membrane so it is possible that Sap specifically may be involved in transport of sulfolipid-1 across the membrane.	5.72001e-23
NC_022663.1\|WP_036392649.1\|1074444_1075338_-\|decaprenyl-diphosphate-synthase	gnl\|CDD\|173288	PRK14827, PRK14827, undecaprenyl pyrophosphate synthase; Provisional.	0

>NC_022663.1|WP_041803325.1|1065493_1066669_-|PPE-family-protein
MVPEFAWLPPEINSARIFAGAGAGPLFAAASAWEGLAAELAGAASSFDAVIAGLTGGPWAGPASVSMAAAAAPYVGWLSAAAVQAETAAASAVTAATAFESAVAATVHPAAVAANRVLLGALVATNFLGQNTPAIAATEFDYVEMWAQDVGAMVGYDAGAGAAAAELMPFGVPPLDLAGLAGQVAAQVSAAATGAVSPALQGALAGVPGVVSGVQSLASSLPLSSVMQVAQVAAQPASMMLGPLMQLANTANAGTAGLAGAAAWEGLADAPKFVGDVNPMKGLGGGAGVGAGIGAELGKARLVGAMSVPPTWEGSMPKGLSSAAMAGLGGLPNAAELAQAAGTGGGMGMMPMPMGMGGAGAGMPGGMMGRGGANPHVVQARPSVIPRTGVG
>NC_022663.1|WP_036393197.1|1063888_1065073_-|PPE-family-protein
MVPEFAWLPPEINSARIFAGAGAGPLFAAASAWAGLAAELAGSASSFDAVIAGLTGGPWAGPASVSMAAAAAPYVGWLSAAAVQAETAAASAVAAATAFESAVAATVHPAAVAANRVLLGALVATNFLGQNTPAIAATEFDYVEMWAQDVGAMVGYDAGAGAAAAELMPFGVPPLDLAGLAGQVAAQVSTAATAATGAVSPALQGALAGVPGVVSGVQSLASAVPVSSVMQVAQVAAQPASMMLGPLMQLGGTANAGTAGLAGATAWEGLADAPKFVGDVNPMKGLGGGAGVGAGIGAELGKARLVGAMSVPPTWEGSMPKGLSSAAMAGLGGLPNAAELAQAAGTGGGMPMMPMPMGAGGAGAGMPGGMMGRGGANPHVVQARPSVIPRTGIG
>NC_022663.1|WP_023365611.1|1062807_1063596_+|GAP-family-protein
MIGKPLSRPGFVIVVVVVASVAMWGTVLVLGLVATADPVRIGISVLLSSQPRAVGQLVAFWLGGIFTSVALATGVLFGLRGFALDVMHRVEVATASSTAGHIQIAMGVTALLIAALAIRLSPGQRIRLGMTGANPSQLQVRTSMTISRLSTRAQFALQARPLRVAFVLGVGMLADLRFLVALTAILASGAAVATQVTAAGVYTLVALTFVELPLASQLAAPAKTGQIMSVLQRWVKARRHQIFAVVIALLGAFLMTRGMGRV
>NC_022663.1|WP_178131770.1|1060671_1062231_-|phospholipase-C
MTENPFRGMSRREFFAKLTGAGAAALLMDFAGPVIEKAYGAGPCSGHLTDIEHIVLLMQENRSFDHYFGTLSSTRGFNDPSPAYQQKGWNPMTQALDPAGITIPFRLDTTRGPILDGECVNDPDHAWIAMHNSWNNGGNDNWLPAQSATRTGPYVPMVMGYYTRQDIPIHHLLADTFTICDGYHCSLLGGTLPNRLYWMSATIDPAGTNGGPQLVEPGFLPEQQYSWRIMPENLEDAGISWKVYQSKDAGRFINTPISNNGLVQAFRQSANPRSNLARFGIAPTYPLDFAADVKGNRLPQVSWLVPPFIQSEHPALPVALGAVAMVNALRILLSNPAVWEKTALIISYDENGGFFDHVTPPTAPPGTPGEYVTVPDINAVTGSGGIRGPIGLGFRVPCLVISPFSRGGLMVHDTFDHTSQLKLIRARFGVPIPNLTAWRDGVVGDMTSAFNFATPPNPTRPNLSHPLLAAVPKLPQCIPNVVLGTTDGTLPAIPYRVPYPQIMPTQESSPTRGIPSGLC
>NC_022663.1|WP_023365606.1|1058924_1060457_-|phospholipase-C
MTRRQFFAKAAAATTAGALTSLAAPIIEKAYGAGPCSGHLTDIEHIVLLMQENRSFDHYFGTLSGTRGFNDPSPAFAQKGWNPATQAVDPAGTTIPFRFDTTRGPLLDGECVNDPDHGWIAMHNSWNGGANDGWLPAQAASSPLQGNVPVTMGYYTRRDLPIHYLLADTFTVCDAYYCSLLGGTTPNRLYWMSAWIDPDGTNGGPILIEPNIQPQQKLSWRIMPQNLEDAAVSWKVYQNKFLGPLNNTVVGYNGLINDFQQAADPRSNLARYGIAPTYPLDFAADVKNNALPKVSWVLPGFLLSEHPALPVSIGAVGIVDVLRILLSNPAVWEKTAVIVNYDENGGFFDHVTPPTPPPGTPGEYVTVPDINAVPGSGGIRGPIGLGFRTPCIVISPYSRGPLMVHDTFDHTSTLKLISARFGVPVPNLSAWRNGVVGDMTSTFNFAVPPNPSKPNLDHPLLKSVPKLPQCVPNAVLGTTTKTSIPYRVPFPQMMPTQETSPTRGIPSGVC
>NC_022663.1|WP_036393202.1|1057005_1058532_-|phospholipase-C
MSRREFLAKATGAGAAAFLTDWAAPVIEKAYAAGPCSGHLTDIEHIVLCLQENRSFDHYFGTLSSVDGFDTPTPLFAQKGWNPQTQAVDPAGITLPYRIDTTRGPNGVGECVNDPDHQWIAAHLSWNGGANDGWLAAQARTRSAANTPVVMGYYARPDIPIHYLLADTFTVCDHYHSSLLGGTMPNRLYWISGTVNPDGDQGGPQIVEPSIQPKLTFSWRIMPQNLSDAGISWKVYNSKLLGGLNDTSLSRNGYVGSFKAAGDPRSDLARYGIAPTYPMDFVLDVINNRLPQVSWVVPLTVDSEHPSFPIAVGAVTIVNLIRTLLRNPAVWEKTALIIAYDEHGGFFDHVTPPTAPPGTPGEWIPNSVDINKVDGSGGIRGPIGLGYRVPCFVISPYSRGGLMVHDQFDHTSQLQLIGKRFGVPVPNLTPWRASLTGDMTSAFNFAAPPDPSRPNLDHPARQLPKVANCVPNVVLGFLNEGLPYRVPYPQTMPVQESGPVRGIPSGIC
>NC_022663.1|WP_036393041.1|1056387_1056645_-|hypothetical-protein
MLGGLSVPLSWGTAVPPDDYDHWAKEDEAAEVAVVPGAVDPEPAESSTDEWDEWAEWNEWEAANAEPRFEVPRSSRVVPHSPAAG
>NC_022663.1|WP_036393043.1|1055943_1056240_-|WXG100-family-type-VII-secretion-target
MATRFMTDPHAMRAMAGRFEVHAQTVEDEARRMWASSQNISGAGWSGLAEATSLDTMGQMNQAFRNIVNMLHGVRDGLIRDANNYEQQEQASQQILSS
>NC_022663.1|WP_023363993.1|1055620_1055905_-|WXG100-family-type-VII-secretion-target
MTINYQFGDVDAHGATIRAQAASLEAEHQAIVRDVLAAGDFWGGAGSVACQEFITQLGRNFQVIYEQANAHGQKVQAAGSNMAQTDSAVGSSWA
>NC_022663.1|WP_023365598.1|1053415_1055425_+|TPM-domain-containing-protein
MRIARLLGVVLTVVTVGLAGGVLLAPPSAAQPPFRLPGYVTDNAGVLSGSDRAEVTSAINELYADRHIRLWVVYVDNFSGQSAMNWGQSTFRSSELGSYDALLAVATVARSYVFLVPSTVPDVSAGQVEELRRNQIEPALRSGDWGGAAVAAANGLNKSPSSSGRVTLLVALGVIVVAVVILLVVTRYRARRRRADALAAARRVDPTDQRALAAVPPDILDDLSRSMVVAVDNAVRTSSNELAVAIDEFGQERTAPFTRAVDNAKAALAQAFSVRQQLDDSVPETPAQRRELLTRVIVSAATADRELEAQTEAFEQLRDLVINAPSRLDMLTQQYVELTTRIAPSQQRLAELHDEFGETALTSVAGNVTAAQERLVFADRNIGMARELSTQAVSGGQSGLVDAVRAAESALGQARSLLDAVDSAAGDIRHAVTELPSVLADVTAGIKQADEQLQKTPGSTSAHTRELVAARDAAAQALEESRNTRGTGVADPLGTFARVSKAGADLDRVLTTVAQEQANAERLNRSFEQALFTAESRVRAVSDYIDTRRGSIGPEARTRLAEAKRQLHAARDKRSTNVTEAVGHANAASTLAANAQALANADVQAAQRAYTRQGGDNAGAILGGIIIGNLLSGGLRGGFGGWSPTSFGGSSSSSSGSSGGGFMGGGGRF
>NC_022663.1|WP_023365619.1|1069349_1071242_-|PPE-family-protein
MNFSVLPPEINSFRMFSGAGSGPMLAAAAAWAGLADELGSAAAAFGSVTSGLAGGPGSAWQGPAAAAMAAVAAPYSGWLSAAAARAAGAAAQAQAVVGAFEAARAAVVHPLAVAANRNVFVQLVMSNLFGQNAPAIAAAEGVYEEMWAADVAAMVGYHGGVSAAAAQLASWSGSVAGLPGLSGLVGGVSGTGAAAGAPSALAAQATAGPAAVSQWLDDFVFNLGFGNIGSFNLGSGNIGGINLGSGNIGDTNLGSGNYGSQNWGGGNTGTANSGSGNIGDFNFGSGNFGSGNLGSGNIGSLNLGSGNFGTINIGSGNLADVSLGSGNTGDFNLGSGNLGGGNIGFGNLGTGNIGFGNKGNDNIGFGLTGNGQIGFGALNSGSNNIGLFNSGNNNIGFFNSGNNNIGWINSGNGNTGFGNAGDFNTGFWNAGSSNTGFGSAGSANFGIFDAGNGNFGSFNVGTHNTGFGNSGAGNTGFMNAGDSNTGAWNAGNVNTGFFNGGNTNTGGFNGGNLNTGFASAVDQPVLNSGFDNQGAGNSGFGNSDPNGTVNSGFFNTGIGNSGISNAGPALIPGFNSGFSNIGTNNAGFVNSGNTLAGISNSGDDSSGIVNSGDQNSGGFNSGSGISGFFR
>NC_022663.1|WP_023365621.1|1071550_1072945_-|glycine--tRNA-ligase
MRYRVASVIDTVVNLAKRRGFVYPSGEIYGGTKSAWDYGPLGVELKENIKRQWWRSVITSRDDVVGIDSSIILPREVWVASGHVEVFHDPLVESLITHKRYRADHLIEAYEAKHGHPPPNGLADIRDPDTGEPGQWTEPREFNMMLKTYLGPIETEEGLHYLRPETAQGIFINFANVVTTSRKKPPFGIGQIGKSFRNEITPGNFIFRTREFEQMEMEFFVEPSTAKEWHQYWIDTRLQWYVELGIDPQNLRLWEHPKEKLSHYSDRTVDIEYKFGFLGNPWGELEGVANRTDFDLSTHSKHSGTDLNFYDQVNDTRYTPYVIEPAAGLTRSFMAFLIDAYSEDEAPNAKGVMEKRTVLRLDARLAPVKAAVLPLSRHADLSPKARDLAAELRTCWNIEFDDAGAIGRRYRRQDEIGTPYCVTVDFDSLEDNAVTVRERDAMTQERIAIDKVADYLAVRLKGCC
>NC_022663.1|WP_023365623.1|1073136_1073529_+|winged-helix-turn-helix-transcriptional-regulator
MATSPATPVAVDDLVGHHEHGARSSSGHPASPAPPPREILDAAGELLRALAAPVRIAIVLQLRESQRCVHELVDALGVPQPLVSQHLKILKAAGVVTGERSGREVLYRLADHHLAHIVVDAVAHASEESP
>NC_022663.1|WP_023365625.1|1073525_1073918_+|transcriptional-repressor
MTGPSVRSTRQRAAISTLLETVDDFRSAQELHDELRRRGENIGLTTVYRTLQSMAAAGVVDTLRTDTGESVYRRCSEHHHHHLVCRSCGSTIEVADHEVEAWAAEVAARHGFSDVSHTIEIFGNCADCRS
>NC_022663.1|WP_023365627.1|1073995_1074445_-|hypothetical-protein
MPSLQQRLASILPDVLSVEQEPDGAMTVRHSGTFASLRVVSIAEGLELVSLTQILAWDLPLTRKIRERAAKQARDVNFGAVTVLEKSPDNGTAKGAAKTAAKTASKTGDVMLRYNFPGAGLSDDALRTLILLVLDTGVQVRDALIAGAR
>NC_022663.1|WP_036392649.1|1074444_1075338_-|decaprenyl-diphosphate-synthase
MAKKAERTLTSADFPQLPPAPDDYPTFPDTSTWPVVFPALPPSPDGGPRRPPQHISKAAAPRIPADRLPNHVAIVMDGNGRWATQRGLRRTEGHKMGEAVVIDIACGAIELGIKWLSLYAFSTENWKRSAEEVRFLMGFNRDVVRRRRENLKEMGVRIRWVGSRPRLWRSVINELAVAEQMTKYNDVITINYCVNYGGRTEIADATRQIAREVAAGRLNPERISESTISRYMQRPDIPDVDLFLRTSGEQRSSNFMLWQAAYAEYIFQDKLWPDYDRRDLWAACEEYASRNRRFGSA
>NC_022663.1|WP_036392645.1|1075330_1076128_-|DNA-repair-protein-RecO
MRLYRDRAVVLRQHKLGEADRIVTLLTRDHGLVRAVAKGVRRTRSKFGARLEPFAHIDAQLHPGRNLDIVTQVVSVDAFATDIVNDYGRYTCGCAMLETAERLAGEERAPAPALHRLTVGALRAVADGRRPRDLLLDAYLLRAMGIAGWAPALTECARCATPGPHRAFHIAAGGSVCAHCRPAGATTPPLGVLELMSALHDGDWAAAEQAPQSHRGYVSGLVAAHLQWHLERQLKTLPLVERTYRIDHTIAERRAALTRQVGECG
>NC_022663.1|WP_036392642.1|1076189_1077698_+|amidase
MVGASESASGAVSGSGNQRLPTLTDLLYQLANGSVTSVDLVRRSLREIQASQSTLNAFRVVFTESALADAAAADRRRAAGDTGPLLGIPIAVKDDVDVAGVPTAYGTEGYVAPATADSEVVRRLKAAGAVIVGKTNTCELGQWPFTSGPGFGHTRNPWARRHTPGGSSGGSAAAVAAGLVTAAIGSDGAGSIRVPAAWTHLVGIKPQRGRISTWPLPEAFNGITVNGVLARTVADAALVLDAASGNVEGDLHRPPPVTASDYVGIAPGPLKIALSTRAPFNGFRAKLHPEILAATRQVGEQLQLLGHTVVRGNPDYSVQMSWDFLARSTAGLWEWAQRLGDDVTLDPRTVSNLRTGHMLSQAILRSARRHEAAAHRRVGSIFDIVDVVLAPTTALPPPLARAFDQMGGLATDRAIIAACPYTWPWNLLGWPAINVPAGFTVEGLPIGVQLMGPANSEGMLISLAAELEAVSGWAAKQPTVWWNEGTDTPAPHSVRPPQRWQR
>NC_022663.1|WP_023365635.1|1077724_1078636_-|GTPase-Era
MTAEFRSGFVCLVGRPNTGKSTLTNALVGAKVAITSMRPQTTRHTIRGIVHRENFQIILVDTPGLHRPRTLLGKRLNDLVRATYAEVDVIGLCIPADEAIGPGDRWILEQIRSVAPGTTLVVIVTKIDKVPKDRVAAQLVAVGELVENLPGSTEIVPVSAVTGAQVDVLVDVLAGALPPGPAYYPDGELTDEPEEVLMAEFIREAALEGVHDELPHSLAVVIDDVSPRDGRDDLIDVHAVVYVERDSQKGIVIGKGGARLRQVGTAARGQIEKLLGTKVYLDLRVKVAKNWQRDPKQLGRLGF
>NC_022663.1|WP_036393017.1|1078632_1078953_-|hypothetical-protein
MAEPADPEDAKLVMLARAAMARAGADSGAAVRDHEGRTYVAVPVNLPALRLTGLQAAVAAAVSSGAIGLEAAALVAGSVDDPGIAALRELSPMAVVVVTDSTGTPL

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Crispr_ID: NC_022663_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022663_4

1067817-1067930

Orphan

Consensus_repeat	Method
CCGATATTGCCGCTGCCCACGTT	CRISPRCasFinder

2 spacers

csa3

The CRISPR arrays of NC_022663_4

>merge|NC_022663|4|1067817-1067930|CRISPRCasFinder
CCGGTGTTGACACTGCCCGCGTTCCCGAAGCCCGTGTTCCCCACGCCAGAATTACCGAAGCCTACGTTGACGGTACCCGAGTTGAAGAAGCCCACGTTACCGCTGCCTGAGTTG

>NC_022663|4|4|1067817-1067930|CRISPRCasFinder
CCGGTGTTGACACTGCCCGCGTT	CCCGAAGCCCGTGTTCCCCACG
CCAGAATTACCGAAGCCTACGTT	GACGGTACCCGAGTTGAAGAAG
CCCACGTTACCGCTGCCTGAGTTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_022663.1\|WP_036393197.1\|1063888_1065073_-\|PPE-family-protein	unknown	unknown	gnl\|CDD\|366325
NC_022663.1\|WP_041803325.1\|1065493_1066669_-\|PPE-family-protein	unknown	unknown	gnl\|CDD\|366325
NC_022663.1\|WP_036393202.1\|1057005_1058532_-\|phospholipase-C	unknown	unknown	gnl\|CDD\|226042
NC_022663.1\|WP_023365625.1\|1073525_1073918_+\|transcriptional-repressor	unknown	unknown	gnl\|CDD\|223806
NC_022663.1\|WP_036393041.1\|1056387_1056645_-\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_036392645.1\|1075330_1076128_-\|DNA-repair-protein-RecO	unknown	unknown	gnl\|CDD\|234622
NC_022663.1\|WP_178131770.1\|1060671_1062231_-\|phospholipase-C	unknown	unknown	gnl\|CDD\|226042
NC_022663.1\|WP_036393043.1\|1055943_1056240_-\|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl\|CDD\|377587
NC_022663.1\|WP_023365606.1\|1058924_1060457_-\|phospholipase-C	unknown	unknown	gnl\|CDD\|226042
NC_022663.1\|WP_023365598.1\|1053415_1055425_+\|TPM-domain-containing-protein	unknown	unknown	gnl\|CDD\|377378
NC_022663.1\|WP_023365627.1\|1073995_1074445_-\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_023365619.1\|1069349_1071242_-\|PPE-family-protein	unknown	unknown	gnl\|CDD\|366325
NC_022663.1\|WP_023365623.1\|1073136_1073529_+\|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|197713
NC_022663.1\|WP_036392642.1\|1076189_1077698_+\|amidase	unknown	unknown	gnl\|CDD\|235686
NC_022663.1\|WP_023365635.1\|1077724_1078636_-\|GTPase-Era	unknown	unknown	gnl\|CDD\|234624
NC_022663.1\|WP_023363993.1\|1055620_1055905_-\|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl\|CDD\|377587
NC_022663.1\|WP_036393017.1\|1078632_1078953_-\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_023365621.1\|1071550_1072945_-\|glycine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235240
NC_022663.1\|WP_023365611.1\|1062807_1063596_+\|GAP-family-protein	unknown	unknown	gnl\|CDD\|378566
NC_022663.1\|WP_036392649.1\|1074444_1075338_-\|decaprenyl-diphosphate-synthase	unknown	unknown	gnl\|CDD\|173288

Protein	Function_ID	Function_description	E-value
NC_022663.1\|WP_036393197.1\|1063888_1065073_-\|PPE-family-protein	gnl\|CDD\|366325	pfam00823, PPE, PPE family. This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	9.63058e-51
NC_022663.1\|WP_041803325.1\|1065493_1066669_-\|PPE-family-protein	gnl\|CDD\|366325	pfam00823, PPE, PPE family. This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	1.02174e-51
NC_022663.1\|WP_036393202.1\|1057005_1058532_-\|phospholipase-C	gnl\|CDD\|226042	COG3511, PlcC, Phospholipase C [Cell envelope biogenesis, outer membrane].	0
NC_022663.1\|WP_023365625.1\|1073525_1073918_+\|transcriptional-repressor	gnl\|CDD\|223806	COG0735, Fur, Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism].	8.06071e-47
NC_022663.1\|WP_023365621.1\|1071550_1072945_-\|glycine--tRNA-ligase	gnl\|CDD\|235240	PRK04173, PRK04173, glycyl-tRNA synthetase; Provisional.	0
NC_022663.1\|WP_036392645.1\|1075330_1076128_-\|DNA-repair-protein-RecO	gnl\|CDD\|234622	PRK00085, recO, DNA repair protein RecO; Reviewed.	6.40078e-88
NC_022663.1\|WP_178131770.1\|1060671_1062231_-\|phospholipase-C	gnl\|CDD\|226042	COG3511, PlcC, Phospholipase C [Cell envelope biogenesis, outer membrane].	0
NC_022663.1\|WP_036393043.1\|1055943_1056240_-\|WXG100-family-type-VII-secretion-target	gnl\|CDD\|377587	pfam06013, WXG100, Proteins of 100 residues with WXG. ESAT-6 is a small protein appears to be of fundamental importance in virulence and protective immunity in Mycobacterium tuberculosis. homologs have been detected in other Gram-positive bacterial species. It may represent a novel secretion system potentially driven by the pfam01580 domains in the YukA-like proteins.	3.26736e-11
NC_022663.1\|WP_023365606.1\|1058924_1060457_-\|phospholipase-C	gnl\|CDD\|226042	COG3511, PlcC, Phospholipase C [Cell envelope biogenesis, outer membrane].	0
NC_022663.1\|WP_023365598.1\|1053415_1055425_+\|TPM-domain-containing-protein	gnl\|CDD\|377378	pfam04536, TPM_phosphatase, TPM domain. This family was first named TPM domain after its founding proteins: TLP18.3, Psb32 and MOLO-1. In Arabidopsis, this domain is called the thylakoid acid phosphatase -TAP - domain and has a Rossmann-like fold. In plants, the family resides in the thylakoid lumen attached to the outer membrane of the chloroplast/plastid. It is active in the photosystem II.	1.67335e-20
NC_022663.1\|WP_023365619.1\|1069349_1071242_-\|PPE-family-protein	gnl\|CDD\|366325	pfam00823, PPE, PPE family. This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	4.16089e-74
NC_022663.1\|WP_023365623.1\|1073136_1073529_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197713	smart00418, HTH_ARSR, helix_turn_helix, Arsenical Resistance Operon Repressor.	1.22235e-18
NC_022663.1\|WP_036392642.1\|1076189_1077698_+\|amidase	gnl\|CDD\|235686	PRK06061, PRK06061, amidase; Provisional.	0
NC_022663.1\|WP_023365635.1\|1077724_1078636_-\|GTPase-Era	gnl\|CDD\|234624	PRK00089, era, GTPase Era; Reviewed.	3.57123e-165
NC_022663.1\|WP_023363993.1\|1055620_1055905_-\|WXG100-family-type-VII-secretion-target	gnl\|CDD\|377587	pfam06013, WXG100, Proteins of 100 residues with WXG. ESAT-6 is a small protein appears to be of fundamental importance in virulence and protective immunity in Mycobacterium tuberculosis. homologs have been detected in other Gram-positive bacterial species. It may represent a novel secretion system potentially driven by the pfam01580 domains in the YukA-like proteins.	5.70515e-10
NC_022663.1\|WP_023365611.1\|1062807_1063596_+\|GAP-family-protein	gnl\|CDD\|378566	pfam11139, SfLAP, Sap, sulfolipid-1-addressing protein. SAP is a transmembrane transport protein with six predicted transmembrane helices, with a hydrophilic domain between helices 3 and 4. This hyrodphobic region is highly variable among identified Gap-like (GPL, peptidoglycolipid, addressing protein) proteins and may be involved in substrate recognition. SAP also belongs to the LysE protein superfamily (pfam01810), whose members have been implicated in small molecule transport in bacteria. Other Gap proteins export metabolites across the cell membrane so it is possible that Sap specifically may be involved in transport of sulfolipid-1 across the membrane.	5.72001e-23
NC_022663.1\|WP_036392649.1\|1074444_1075338_-\|decaprenyl-diphosphate-synthase	gnl\|CDD\|173288	PRK14827, PRK14827, undecaprenyl pyrophosphate synthase; Provisional.	0

>NC_022663.1|WP_041803325.1|1065493_1066669_-|PPE-family-protein
MVPEFAWLPPEINSARIFAGAGAGPLFAAASAWEGLAAELAGAASSFDAVIAGLTGGPWAGPASVSMAAAAAPYVGWLSAAAVQAETAAASAVTAATAFESAVAATVHPAAVAANRVLLGALVATNFLGQNTPAIAATEFDYVEMWAQDVGAMVGYDAGAGAAAAELMPFGVPPLDLAGLAGQVAAQVSAAATGAVSPALQGALAGVPGVVSGVQSLASSLPLSSVMQVAQVAAQPASMMLGPLMQLANTANAGTAGLAGAAAWEGLADAPKFVGDVNPMKGLGGGAGVGAGIGAELGKARLVGAMSVPPTWEGSMPKGLSSAAMAGLGGLPNAAELAQAAGTGGGMGMMPMPMGMGGAGAGMPGGMMGRGGANPHVVQARPSVIPRTGVG
>NC_022663.1|WP_036393197.1|1063888_1065073_-|PPE-family-protein
MVPEFAWLPPEINSARIFAGAGAGPLFAAASAWAGLAAELAGSASSFDAVIAGLTGGPWAGPASVSMAAAAAPYVGWLSAAAVQAETAAASAVAAATAFESAVAATVHPAAVAANRVLLGALVATNFLGQNTPAIAATEFDYVEMWAQDVGAMVGYDAGAGAAAAELMPFGVPPLDLAGLAGQVAAQVSTAATAATGAVSPALQGALAGVPGVVSGVQSLASAVPVSSVMQVAQVAAQPASMMLGPLMQLGGTANAGTAGLAGATAWEGLADAPKFVGDVNPMKGLGGGAGVGAGIGAELGKARLVGAMSVPPTWEGSMPKGLSSAAMAGLGGLPNAAELAQAAGTGGGMPMMPMPMGAGGAGAGMPGGMMGRGGANPHVVQARPSVIPRTGIG
>NC_022663.1|WP_023365611.1|1062807_1063596_+|GAP-family-protein
MIGKPLSRPGFVIVVVVVASVAMWGTVLVLGLVATADPVRIGISVLLSSQPRAVGQLVAFWLGGIFTSVALATGVLFGLRGFALDVMHRVEVATASSTAGHIQIAMGVTALLIAALAIRLSPGQRIRLGMTGANPSQLQVRTSMTISRLSTRAQFALQARPLRVAFVLGVGMLADLRFLVALTAILASGAAVATQVTAAGVYTLVALTFVELPLASQLAAPAKTGQIMSVLQRWVKARRHQIFAVVIALLGAFLMTRGMGRV
>NC_022663.1|WP_178131770.1|1060671_1062231_-|phospholipase-C
MTENPFRGMSRREFFAKLTGAGAAALLMDFAGPVIEKAYGAGPCSGHLTDIEHIVLLMQENRSFDHYFGTLSSTRGFNDPSPAYQQKGWNPMTQALDPAGITIPFRLDTTRGPILDGECVNDPDHAWIAMHNSWNNGGNDNWLPAQSATRTGPYVPMVMGYYTRQDIPIHHLLADTFTICDGYHCSLLGGTLPNRLYWMSATIDPAGTNGGPQLVEPGFLPEQQYSWRIMPENLEDAGISWKVYQSKDAGRFINTPISNNGLVQAFRQSANPRSNLARFGIAPTYPLDFAADVKGNRLPQVSWLVPPFIQSEHPALPVALGAVAMVNALRILLSNPAVWEKTALIISYDENGGFFDHVTPPTAPPGTPGEYVTVPDINAVTGSGGIRGPIGLGFRVPCLVISPFSRGGLMVHDTFDHTSQLKLIRARFGVPIPNLTAWRDGVVGDMTSAFNFATPPNPTRPNLSHPLLAAVPKLPQCIPNVVLGTTDGTLPAIPYRVPYPQIMPTQESSPTRGIPSGLC
>NC_022663.1|WP_023365606.1|1058924_1060457_-|phospholipase-C
MTRRQFFAKAAAATTAGALTSLAAPIIEKAYGAGPCSGHLTDIEHIVLLMQENRSFDHYFGTLSGTRGFNDPSPAFAQKGWNPATQAVDPAGTTIPFRFDTTRGPLLDGECVNDPDHGWIAMHNSWNGGANDGWLPAQAASSPLQGNVPVTMGYYTRRDLPIHYLLADTFTVCDAYYCSLLGGTTPNRLYWMSAWIDPDGTNGGPILIEPNIQPQQKLSWRIMPQNLEDAAVSWKVYQNKFLGPLNNTVVGYNGLINDFQQAADPRSNLARYGIAPTYPLDFAADVKNNALPKVSWVLPGFLLSEHPALPVSIGAVGIVDVLRILLSNPAVWEKTAVIVNYDENGGFFDHVTPPTPPPGTPGEYVTVPDINAVPGSGGIRGPIGLGFRTPCIVISPYSRGPLMVHDTFDHTSTLKLISARFGVPVPNLSAWRNGVVGDMTSTFNFAVPPNPSKPNLDHPLLKSVPKLPQCVPNAVLGTTTKTSIPYRVPFPQMMPTQETSPTRGIPSGVC
>NC_022663.1|WP_036393202.1|1057005_1058532_-|phospholipase-C
MSRREFLAKATGAGAAAFLTDWAAPVIEKAYAAGPCSGHLTDIEHIVLCLQENRSFDHYFGTLSSVDGFDTPTPLFAQKGWNPQTQAVDPAGITLPYRIDTTRGPNGVGECVNDPDHQWIAAHLSWNGGANDGWLAAQARTRSAANTPVVMGYYARPDIPIHYLLADTFTVCDHYHSSLLGGTMPNRLYWISGTVNPDGDQGGPQIVEPSIQPKLTFSWRIMPQNLSDAGISWKVYNSKLLGGLNDTSLSRNGYVGSFKAAGDPRSDLARYGIAPTYPMDFVLDVINNRLPQVSWVVPLTVDSEHPSFPIAVGAVTIVNLIRTLLRNPAVWEKTALIIAYDEHGGFFDHVTPPTAPPGTPGEWIPNSVDINKVDGSGGIRGPIGLGYRVPCFVISPYSRGGLMVHDQFDHTSQLQLIGKRFGVPVPNLTPWRASLTGDMTSAFNFAAPPDPSRPNLDHPARQLPKVANCVPNVVLGFLNEGLPYRVPYPQTMPVQESGPVRGIPSGIC
>NC_022663.1|WP_036393041.1|1056387_1056645_-|hypothetical-protein
MLGGLSVPLSWGTAVPPDDYDHWAKEDEAAEVAVVPGAVDPEPAESSTDEWDEWAEWNEWEAANAEPRFEVPRSSRVVPHSPAAG
>NC_022663.1|WP_036393043.1|1055943_1056240_-|WXG100-family-type-VII-secretion-target
MATRFMTDPHAMRAMAGRFEVHAQTVEDEARRMWASSQNISGAGWSGLAEATSLDTMGQMNQAFRNIVNMLHGVRDGLIRDANNYEQQEQASQQILSS
>NC_022663.1|WP_023363993.1|1055620_1055905_-|WXG100-family-type-VII-secretion-target
MTINYQFGDVDAHGATIRAQAASLEAEHQAIVRDVLAAGDFWGGAGSVACQEFITQLGRNFQVIYEQANAHGQKVQAAGSNMAQTDSAVGSSWA
>NC_022663.1|WP_023365598.1|1053415_1055425_+|TPM-domain-containing-protein
MRIARLLGVVLTVVTVGLAGGVLLAPPSAAQPPFRLPGYVTDNAGVLSGSDRAEVTSAINELYADRHIRLWVVYVDNFSGQSAMNWGQSTFRSSELGSYDALLAVATVARSYVFLVPSTVPDVSAGQVEELRRNQIEPALRSGDWGGAAVAAANGLNKSPSSSGRVTLLVALGVIVVAVVILLVVTRYRARRRRADALAAARRVDPTDQRALAAVPPDILDDLSRSMVVAVDNAVRTSSNELAVAIDEFGQERTAPFTRAVDNAKAALAQAFSVRQQLDDSVPETPAQRRELLTRVIVSAATADRELEAQTEAFEQLRDLVINAPSRLDMLTQQYVELTTRIAPSQQRLAELHDEFGETALTSVAGNVTAAQERLVFADRNIGMARELSTQAVSGGQSGLVDAVRAAESALGQARSLLDAVDSAAGDIRHAVTELPSVLADVTAGIKQADEQLQKTPGSTSAHTRELVAARDAAAQALEESRNTRGTGVADPLGTFARVSKAGADLDRVLTTVAQEQANAERLNRSFEQALFTAESRVRAVSDYIDTRRGSIGPEARTRLAEAKRQLHAARDKRSTNVTEAVGHANAASTLAANAQALANADVQAAQRAYTRQGGDNAGAILGGIIIGNLLSGGLRGGFGGWSPTSFGGSSSSSSGSSGGGFMGGGGRF
>NC_022663.1|WP_023365619.1|1069349_1071242_-|PPE-family-protein
MNFSVLPPEINSFRMFSGAGSGPMLAAAAAWAGLADELGSAAAAFGSVTSGLAGGPGSAWQGPAAAAMAAVAAPYSGWLSAAAARAAGAAAQAQAVVGAFEAARAAVVHPLAVAANRNVFVQLVMSNLFGQNAPAIAAAEGVYEEMWAADVAAMVGYHGGVSAAAAQLASWSGSVAGLPGLSGLVGGVSGTGAAAGAPSALAAQATAGPAAVSQWLDDFVFNLGFGNIGSFNLGSGNIGGINLGSGNIGDTNLGSGNYGSQNWGGGNTGTANSGSGNIGDFNFGSGNFGSGNLGSGNIGSLNLGSGNFGTINIGSGNLADVSLGSGNTGDFNLGSGNLGGGNIGFGNLGTGNIGFGNKGNDNIGFGLTGNGQIGFGALNSGSNNIGLFNSGNNNIGFFNSGNNNIGWINSGNGNTGFGNAGDFNTGFWNAGSSNTGFGSAGSANFGIFDAGNGNFGSFNVGTHNTGFGNSGAGNTGFMNAGDSNTGAWNAGNVNTGFFNGGNTNTGGFNGGNLNTGFASAVDQPVLNSGFDNQGAGNSGFGNSDPNGTVNSGFFNTGIGNSGISNAGPALIPGFNSGFSNIGTNNAGFVNSGNTLAGISNSGDDSSGIVNSGDQNSGGFNSGSGISGFFR
>NC_022663.1|WP_023365621.1|1071550_1072945_-|glycine--tRNA-ligase
MRYRVASVIDTVVNLAKRRGFVYPSGEIYGGTKSAWDYGPLGVELKENIKRQWWRSVITSRDDVVGIDSSIILPREVWVASGHVEVFHDPLVESLITHKRYRADHLIEAYEAKHGHPPPNGLADIRDPDTGEPGQWTEPREFNMMLKTYLGPIETEEGLHYLRPETAQGIFINFANVVTTSRKKPPFGIGQIGKSFRNEITPGNFIFRTREFEQMEMEFFVEPSTAKEWHQYWIDTRLQWYVELGIDPQNLRLWEHPKEKLSHYSDRTVDIEYKFGFLGNPWGELEGVANRTDFDLSTHSKHSGTDLNFYDQVNDTRYTPYVIEPAAGLTRSFMAFLIDAYSEDEAPNAKGVMEKRTVLRLDARLAPVKAAVLPLSRHADLSPKARDLAAELRTCWNIEFDDAGAIGRRYRRQDEIGTPYCVTVDFDSLEDNAVTVRERDAMTQERIAIDKVADYLAVRLKGCC
>NC_022663.1|WP_023365623.1|1073136_1073529_+|winged-helix-turn-helix-transcriptional-regulator
MATSPATPVAVDDLVGHHEHGARSSSGHPASPAPPPREILDAAGELLRALAAPVRIAIVLQLRESQRCVHELVDALGVPQPLVSQHLKILKAAGVVTGERSGREVLYRLADHHLAHIVVDAVAHASEESP
>NC_022663.1|WP_023365625.1|1073525_1073918_+|transcriptional-repressor
MTGPSVRSTRQRAAISTLLETVDDFRSAQELHDELRRRGENIGLTTVYRTLQSMAAAGVVDTLRTDTGESVYRRCSEHHHHHLVCRSCGSTIEVADHEVEAWAAEVAARHGFSDVSHTIEIFGNCADCRS
>NC_022663.1|WP_023365627.1|1073995_1074445_-|hypothetical-protein
MPSLQQRLASILPDVLSVEQEPDGAMTVRHSGTFASLRVVSIAEGLELVSLTQILAWDLPLTRKIRERAAKQARDVNFGAVTVLEKSPDNGTAKGAAKTAAKTASKTGDVMLRYNFPGAGLSDDALRTLILLVLDTGVQVRDALIAGAR
>NC_022663.1|WP_036392649.1|1074444_1075338_-|decaprenyl-diphosphate-synthase
MAKKAERTLTSADFPQLPPAPDDYPTFPDTSTWPVVFPALPPSPDGGPRRPPQHISKAAAPRIPADRLPNHVAIVMDGNGRWATQRGLRRTEGHKMGEAVVIDIACGAIELGIKWLSLYAFSTENWKRSAEEVRFLMGFNRDVVRRRRENLKEMGVRIRWVGSRPRLWRSVINELAVAEQMTKYNDVITINYCVNYGGRTEIADATRQIAREVAAGRLNPERISESTISRYMQRPDIPDVDLFLRTSGEQRSSNFMLWQAAYAEYIFQDKLWPDYDRRDLWAACEEYASRNRRFGSA
>NC_022663.1|WP_036392645.1|1075330_1076128_-|DNA-repair-protein-RecO
MRLYRDRAVVLRQHKLGEADRIVTLLTRDHGLVRAVAKGVRRTRSKFGARLEPFAHIDAQLHPGRNLDIVTQVVSVDAFATDIVNDYGRYTCGCAMLETAERLAGEERAPAPALHRLTVGALRAVADGRRPRDLLLDAYLLRAMGIAGWAPALTECARCATPGPHRAFHIAAGGSVCAHCRPAGATTPPLGVLELMSALHDGDWAAAEQAPQSHRGYVSGLVAAHLQWHLERQLKTLPLVERTYRIDHTIAERRAALTRQVGECG
>NC_022663.1|WP_036392642.1|1076189_1077698_+|amidase
MVGASESASGAVSGSGNQRLPTLTDLLYQLANGSVTSVDLVRRSLREIQASQSTLNAFRVVFTESALADAAAADRRRAAGDTGPLLGIPIAVKDDVDVAGVPTAYGTEGYVAPATADSEVVRRLKAAGAVIVGKTNTCELGQWPFTSGPGFGHTRNPWARRHTPGGSSGGSAAAVAAGLVTAAIGSDGAGSIRVPAAWTHLVGIKPQRGRISTWPLPEAFNGITVNGVLARTVADAALVLDAASGNVEGDLHRPPPVTASDYVGIAPGPLKIALSTRAPFNGFRAKLHPEILAATRQVGEQLQLLGHTVVRGNPDYSVQMSWDFLARSTAGLWEWAQRLGDDVTLDPRTVSNLRTGHMLSQAILRSARRHEAAAHRRVGSIFDIVDVVLAPTTALPPPLARAFDQMGGLATDRAIIAACPYTWPWNLLGWPAINVPAGFTVEGLPIGVQLMGPANSEGMLISLAAELEAVSGWAAKQPTVWWNEGTDTPAPHSVRPPQRWQR
>NC_022663.1|WP_023365635.1|1077724_1078636_-|GTPase-Era
MTAEFRSGFVCLVGRPNTGKSTLTNALVGAKVAITSMRPQTTRHTIRGIVHRENFQIILVDTPGLHRPRTLLGKRLNDLVRATYAEVDVIGLCIPADEAIGPGDRWILEQIRSVAPGTTLVVIVTKIDKVPKDRVAAQLVAVGELVENLPGSTEIVPVSAVTGAQVDVLVDVLAGALPPGPAYYPDGELTDEPEEVLMAEFIREAALEGVHDELPHSLAVVIDDVSPRDGRDDLIDVHAVVYVERDSQKGIVIGKGGARLRQVGTAARGQIEKLLGTKVYLDLRVKVAKNWQRDPKQLGRLGF
>NC_022663.1|WP_036393017.1|1078632_1078953_-|hypothetical-protein
MAEPADPEDAKLVMLARAAMARAGADSGAAVRDHEGRTYVAVPVNLPALRLTGLQAAVAAAVSSGAIGLEAAALVAGSVDDPGIAALRELSPMAVVVVTDSTGTPL

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Crispr_ID: NC_022663_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022663_5

1068033-1068430

Orphan

Consensus_repeat	Method
CCGATATTGCCGCTGCCCACGTT	CRISPRCasFinder

7 spacers

csa3

The CRISPR arrays of NC_022663_5

>merge|NC_022663|5|1068033-1068430|CRISPRCasFinder
CCGAAATTGCCATTCCCGGTGTTACCGAAGCCGACGTTGCTACTCCCGGAATTTCCGCTGCCGAAATTGAAGTTACCACCATTACCGTTGCCGAAATTCGTGTCGCCGATATTGCCGCTGCCCACGTTGGTGTTGCCGATATTTCCACCACCCAGATTGGTGCTACCGATATTGCCGCTGCCCAGGTTCTGGCTGCCGAAGTTTCCGCTACCGACGTTGAAGTTGCCGACGTTGCCGCTGCCCAGGTTGATGTCGCCCCGGTTTCCGCCACCGATGTTGGTGCTGCCGATATTGCCGCTGCCCAAGTTGAACGAGCCGACGTTGCCGCTTCCGATGTTCGTGTCACCGATGTTGCCGCTACCCAGGTTGAGCGAGCCGATGTTGCCGAAACCGAAGTT

>NC_022663|5|5|1068033-1068430|CRISPRCasFinder
CCGAAATTGCCATTCCCGGTGTT	ACCGAAGCCGACGTTGCTACTC
CCGGAATTTCCGCTGCCGAAATT	GAAGTTACCACCATTACCGTTGCCGAAATTCGTGTCG
CCGATATTGCCGCTGCCCACGTT	GGTGTTGCCGATATTTCCACCACCCAGATTGGTGCTA
CCGATATTGCCGCTGCCCAGGTT	CTGGCTGCCGAAGTTTCCGCTA
CCGACGTTGAAGTTGCCGACGTT	GCCGCTGCCCAGGTTGATGTCGCCCCGGTTTCCGCCA
CCGATGTTGGTGCTGCCGATATT	GCCGCTGCCCAAGTTGAACGAG
CCGACGTTGCCGCTTCCGATGTT	CGTGTCACCGATGTTGCCGCTACCCAGGTTGAGCGAG
CCGATGTTGCCGAAACCGAAGTT

Protein	Signature genes	Signature genes Name	Protein_function
NC_022663.1\|WP_036393197.1\|1063888_1065073_-\|PPE-family-protein	unknown	unknown	gnl\|CDD\|366325
NC_022663.1\|WP_041803325.1\|1065493_1066669_-\|PPE-family-protein	unknown	unknown	gnl\|CDD\|366325
NC_022663.1\|WP_036393202.1\|1057005_1058532_-\|phospholipase-C	unknown	unknown	gnl\|CDD\|226042
NC_022663.1\|WP_023365625.1\|1073525_1073918_+\|transcriptional-repressor	unknown	unknown	gnl\|CDD\|223806
NC_022663.1\|WP_036393041.1\|1056387_1056645_-\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_036392645.1\|1075330_1076128_-\|DNA-repair-protein-RecO	unknown	unknown	gnl\|CDD\|234622
NC_022663.1\|WP_178131770.1\|1060671_1062231_-\|phospholipase-C	unknown	unknown	gnl\|CDD\|226042
NC_022663.1\|WP_036393043.1\|1055943_1056240_-\|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl\|CDD\|377587
NC_022663.1\|WP_023365606.1\|1058924_1060457_-\|phospholipase-C	unknown	unknown	gnl\|CDD\|226042
NC_022663.1\|WP_023365598.1\|1053415_1055425_+\|TPM-domain-containing-protein	unknown	unknown	gnl\|CDD\|377378
NC_022663.1\|WP_023365627.1\|1073995_1074445_-\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_023365619.1\|1069349_1071242_-\|PPE-family-protein	unknown	unknown	gnl\|CDD\|366325
NC_022663.1\|WP_023365623.1\|1073136_1073529_+\|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|197713
NC_022663.1\|WP_036392642.1\|1076189_1077698_+\|amidase	unknown	unknown	gnl\|CDD\|235686
NC_022663.1\|WP_023365635.1\|1077724_1078636_-\|GTPase-Era	unknown	unknown	gnl\|CDD\|234624
NC_022663.1\|WP_023363993.1\|1055620_1055905_-\|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl\|CDD\|377587
NC_022663.1\|WP_036393017.1\|1078632_1078953_-\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_023365621.1\|1071550_1072945_-\|glycine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235240
NC_022663.1\|WP_023365611.1\|1062807_1063596_+\|GAP-family-protein	unknown	unknown	gnl\|CDD\|378566
NC_022663.1\|WP_036392649.1\|1074444_1075338_-\|decaprenyl-diphosphate-synthase	unknown	unknown	gnl\|CDD\|173288

Protein	Function_ID	Function_description	E-value
NC_022663.1\|WP_036393197.1\|1063888_1065073_-\|PPE-family-protein	gnl\|CDD\|366325	pfam00823, PPE, PPE family. This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	9.63058e-51
NC_022663.1\|WP_041803325.1\|1065493_1066669_-\|PPE-family-protein	gnl\|CDD\|366325	pfam00823, PPE, PPE family. This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	1.02174e-51
NC_022663.1\|WP_036393202.1\|1057005_1058532_-\|phospholipase-C	gnl\|CDD\|226042	COG3511, PlcC, Phospholipase C [Cell envelope biogenesis, outer membrane].	0
NC_022663.1\|WP_023365625.1\|1073525_1073918_+\|transcriptional-repressor	gnl\|CDD\|223806	COG0735, Fur, Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism].	8.06071e-47
NC_022663.1\|WP_023365621.1\|1071550_1072945_-\|glycine--tRNA-ligase	gnl\|CDD\|235240	PRK04173, PRK04173, glycyl-tRNA synthetase; Provisional.	0
NC_022663.1\|WP_036392645.1\|1075330_1076128_-\|DNA-repair-protein-RecO	gnl\|CDD\|234622	PRK00085, recO, DNA repair protein RecO; Reviewed.	6.40078e-88
NC_022663.1\|WP_178131770.1\|1060671_1062231_-\|phospholipase-C	gnl\|CDD\|226042	COG3511, PlcC, Phospholipase C [Cell envelope biogenesis, outer membrane].	0
NC_022663.1\|WP_036393043.1\|1055943_1056240_-\|WXG100-family-type-VII-secretion-target	gnl\|CDD\|377587	pfam06013, WXG100, Proteins of 100 residues with WXG. ESAT-6 is a small protein appears to be of fundamental importance in virulence and protective immunity in Mycobacterium tuberculosis. homologs have been detected in other Gram-positive bacterial species. It may represent a novel secretion system potentially driven by the pfam01580 domains in the YukA-like proteins.	3.26736e-11
NC_022663.1\|WP_023365606.1\|1058924_1060457_-\|phospholipase-C	gnl\|CDD\|226042	COG3511, PlcC, Phospholipase C [Cell envelope biogenesis, outer membrane].	0
NC_022663.1\|WP_023365598.1\|1053415_1055425_+\|TPM-domain-containing-protein	gnl\|CDD\|377378	pfam04536, TPM_phosphatase, TPM domain. This family was first named TPM domain after its founding proteins: TLP18.3, Psb32 and MOLO-1. In Arabidopsis, this domain is called the thylakoid acid phosphatase -TAP - domain and has a Rossmann-like fold. In plants, the family resides in the thylakoid lumen attached to the outer membrane of the chloroplast/plastid. It is active in the photosystem II.	1.67335e-20
NC_022663.1\|WP_023365619.1\|1069349_1071242_-\|PPE-family-protein	gnl\|CDD\|366325	pfam00823, PPE, PPE family. This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	4.16089e-74
NC_022663.1\|WP_023365623.1\|1073136_1073529_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197713	smart00418, HTH_ARSR, helix_turn_helix, Arsenical Resistance Operon Repressor.	1.22235e-18
NC_022663.1\|WP_036392642.1\|1076189_1077698_+\|amidase	gnl\|CDD\|235686	PRK06061, PRK06061, amidase; Provisional.	0
NC_022663.1\|WP_023365635.1\|1077724_1078636_-\|GTPase-Era	gnl\|CDD\|234624	PRK00089, era, GTPase Era; Reviewed.	3.57123e-165
NC_022663.1\|WP_023363993.1\|1055620_1055905_-\|WXG100-family-type-VII-secretion-target	gnl\|CDD\|377587	pfam06013, WXG100, Proteins of 100 residues with WXG. ESAT-6 is a small protein appears to be of fundamental importance in virulence and protective immunity in Mycobacterium tuberculosis. homologs have been detected in other Gram-positive bacterial species. It may represent a novel secretion system potentially driven by the pfam01580 domains in the YukA-like proteins.	5.70515e-10
NC_022663.1\|WP_023365611.1\|1062807_1063596_+\|GAP-family-protein	gnl\|CDD\|378566	pfam11139, SfLAP, Sap, sulfolipid-1-addressing protein. SAP is a transmembrane transport protein with six predicted transmembrane helices, with a hydrophilic domain between helices 3 and 4. This hyrodphobic region is highly variable among identified Gap-like (GPL, peptidoglycolipid, addressing protein) proteins and may be involved in substrate recognition. SAP also belongs to the LysE protein superfamily (pfam01810), whose members have been implicated in small molecule transport in bacteria. Other Gap proteins export metabolites across the cell membrane so it is possible that Sap specifically may be involved in transport of sulfolipid-1 across the membrane.	5.72001e-23
NC_022663.1\|WP_036392649.1\|1074444_1075338_-\|decaprenyl-diphosphate-synthase	gnl\|CDD\|173288	PRK14827, PRK14827, undecaprenyl pyrophosphate synthase; Provisional.	0

>NC_022663.1|WP_041803325.1|1065493_1066669_-|PPE-family-protein
MVPEFAWLPPEINSARIFAGAGAGPLFAAASAWEGLAAELAGAASSFDAVIAGLTGGPWAGPASVSMAAAAAPYVGWLSAAAVQAETAAASAVTAATAFESAVAATVHPAAVAANRVLLGALVATNFLGQNTPAIAATEFDYVEMWAQDVGAMVGYDAGAGAAAAELMPFGVPPLDLAGLAGQVAAQVSAAATGAVSPALQGALAGVPGVVSGVQSLASSLPLSSVMQVAQVAAQPASMMLGPLMQLANTANAGTAGLAGAAAWEGLADAPKFVGDVNPMKGLGGGAGVGAGIGAELGKARLVGAMSVPPTWEGSMPKGLSSAAMAGLGGLPNAAELAQAAGTGGGMGMMPMPMGMGGAGAGMPGGMMGRGGANPHVVQARPSVIPRTGVG
>NC_022663.1|WP_036393197.1|1063888_1065073_-|PPE-family-protein
MVPEFAWLPPEINSARIFAGAGAGPLFAAASAWAGLAAELAGSASSFDAVIAGLTGGPWAGPASVSMAAAAAPYVGWLSAAAVQAETAAASAVAAATAFESAVAATVHPAAVAANRVLLGALVATNFLGQNTPAIAATEFDYVEMWAQDVGAMVGYDAGAGAAAAELMPFGVPPLDLAGLAGQVAAQVSTAATAATGAVSPALQGALAGVPGVVSGVQSLASAVPVSSVMQVAQVAAQPASMMLGPLMQLGGTANAGTAGLAGATAWEGLADAPKFVGDVNPMKGLGGGAGVGAGIGAELGKARLVGAMSVPPTWEGSMPKGLSSAAMAGLGGLPNAAELAQAAGTGGGMPMMPMPMGAGGAGAGMPGGMMGRGGANPHVVQARPSVIPRTGIG
>NC_022663.1|WP_023365611.1|1062807_1063596_+|GAP-family-protein
MIGKPLSRPGFVIVVVVVASVAMWGTVLVLGLVATADPVRIGISVLLSSQPRAVGQLVAFWLGGIFTSVALATGVLFGLRGFALDVMHRVEVATASSTAGHIQIAMGVTALLIAALAIRLSPGQRIRLGMTGANPSQLQVRTSMTISRLSTRAQFALQARPLRVAFVLGVGMLADLRFLVALTAILASGAAVATQVTAAGVYTLVALTFVELPLASQLAAPAKTGQIMSVLQRWVKARRHQIFAVVIALLGAFLMTRGMGRV
>NC_022663.1|WP_178131770.1|1060671_1062231_-|phospholipase-C
MTENPFRGMSRREFFAKLTGAGAAALLMDFAGPVIEKAYGAGPCSGHLTDIEHIVLLMQENRSFDHYFGTLSSTRGFNDPSPAYQQKGWNPMTQALDPAGITIPFRLDTTRGPILDGECVNDPDHAWIAMHNSWNNGGNDNWLPAQSATRTGPYVPMVMGYYTRQDIPIHHLLADTFTICDGYHCSLLGGTLPNRLYWMSATIDPAGTNGGPQLVEPGFLPEQQYSWRIMPENLEDAGISWKVYQSKDAGRFINTPISNNGLVQAFRQSANPRSNLARFGIAPTYPLDFAADVKGNRLPQVSWLVPPFIQSEHPALPVALGAVAMVNALRILLSNPAVWEKTALIISYDENGGFFDHVTPPTAPPGTPGEYVTVPDINAVTGSGGIRGPIGLGFRVPCLVISPFSRGGLMVHDTFDHTSQLKLIRARFGVPIPNLTAWRDGVVGDMTSAFNFATPPNPTRPNLSHPLLAAVPKLPQCIPNVVLGTTDGTLPAIPYRVPYPQIMPTQESSPTRGIPSGLC
>NC_022663.1|WP_023365606.1|1058924_1060457_-|phospholipase-C
MTRRQFFAKAAAATTAGALTSLAAPIIEKAYGAGPCSGHLTDIEHIVLLMQENRSFDHYFGTLSGTRGFNDPSPAFAQKGWNPATQAVDPAGTTIPFRFDTTRGPLLDGECVNDPDHGWIAMHNSWNGGANDGWLPAQAASSPLQGNVPVTMGYYTRRDLPIHYLLADTFTVCDAYYCSLLGGTTPNRLYWMSAWIDPDGTNGGPILIEPNIQPQQKLSWRIMPQNLEDAAVSWKVYQNKFLGPLNNTVVGYNGLINDFQQAADPRSNLARYGIAPTYPLDFAADVKNNALPKVSWVLPGFLLSEHPALPVSIGAVGIVDVLRILLSNPAVWEKTAVIVNYDENGGFFDHVTPPTPPPGTPGEYVTVPDINAVPGSGGIRGPIGLGFRTPCIVISPYSRGPLMVHDTFDHTSTLKLISARFGVPVPNLSAWRNGVVGDMTSTFNFAVPPNPSKPNLDHPLLKSVPKLPQCVPNAVLGTTTKTSIPYRVPFPQMMPTQETSPTRGIPSGVC
>NC_022663.1|WP_036393202.1|1057005_1058532_-|phospholipase-C
MSRREFLAKATGAGAAAFLTDWAAPVIEKAYAAGPCSGHLTDIEHIVLCLQENRSFDHYFGTLSSVDGFDTPTPLFAQKGWNPQTQAVDPAGITLPYRIDTTRGPNGVGECVNDPDHQWIAAHLSWNGGANDGWLAAQARTRSAANTPVVMGYYARPDIPIHYLLADTFTVCDHYHSSLLGGTMPNRLYWISGTVNPDGDQGGPQIVEPSIQPKLTFSWRIMPQNLSDAGISWKVYNSKLLGGLNDTSLSRNGYVGSFKAAGDPRSDLARYGIAPTYPMDFVLDVINNRLPQVSWVVPLTVDSEHPSFPIAVGAVTIVNLIRTLLRNPAVWEKTALIIAYDEHGGFFDHVTPPTAPPGTPGEWIPNSVDINKVDGSGGIRGPIGLGYRVPCFVISPYSRGGLMVHDQFDHTSQLQLIGKRFGVPVPNLTPWRASLTGDMTSAFNFAAPPDPSRPNLDHPARQLPKVANCVPNVVLGFLNEGLPYRVPYPQTMPVQESGPVRGIPSGIC
>NC_022663.1|WP_036393041.1|1056387_1056645_-|hypothetical-protein
MLGGLSVPLSWGTAVPPDDYDHWAKEDEAAEVAVVPGAVDPEPAESSTDEWDEWAEWNEWEAANAEPRFEVPRSSRVVPHSPAAG
>NC_022663.1|WP_036393043.1|1055943_1056240_-|WXG100-family-type-VII-secretion-target
MATRFMTDPHAMRAMAGRFEVHAQTVEDEARRMWASSQNISGAGWSGLAEATSLDTMGQMNQAFRNIVNMLHGVRDGLIRDANNYEQQEQASQQILSS
>NC_022663.1|WP_023363993.1|1055620_1055905_-|WXG100-family-type-VII-secretion-target
MTINYQFGDVDAHGATIRAQAASLEAEHQAIVRDVLAAGDFWGGAGSVACQEFITQLGRNFQVIYEQANAHGQKVQAAGSNMAQTDSAVGSSWA
>NC_022663.1|WP_023365598.1|1053415_1055425_+|TPM-domain-containing-protein
MRIARLLGVVLTVVTVGLAGGVLLAPPSAAQPPFRLPGYVTDNAGVLSGSDRAEVTSAINELYADRHIRLWVVYVDNFSGQSAMNWGQSTFRSSELGSYDALLAVATVARSYVFLVPSTVPDVSAGQVEELRRNQIEPALRSGDWGGAAVAAANGLNKSPSSSGRVTLLVALGVIVVAVVILLVVTRYRARRRRADALAAARRVDPTDQRALAAVPPDILDDLSRSMVVAVDNAVRTSSNELAVAIDEFGQERTAPFTRAVDNAKAALAQAFSVRQQLDDSVPETPAQRRELLTRVIVSAATADRELEAQTEAFEQLRDLVINAPSRLDMLTQQYVELTTRIAPSQQRLAELHDEFGETALTSVAGNVTAAQERLVFADRNIGMARELSTQAVSGGQSGLVDAVRAAESALGQARSLLDAVDSAAGDIRHAVTELPSVLADVTAGIKQADEQLQKTPGSTSAHTRELVAARDAAAQALEESRNTRGTGVADPLGTFARVSKAGADLDRVLTTVAQEQANAERLNRSFEQALFTAESRVRAVSDYIDTRRGSIGPEARTRLAEAKRQLHAARDKRSTNVTEAVGHANAASTLAANAQALANADVQAAQRAYTRQGGDNAGAILGGIIIGNLLSGGLRGGFGGWSPTSFGGSSSSSSGSSGGGFMGGGGRF
>NC_022663.1|WP_023365619.1|1069349_1071242_-|PPE-family-protein
MNFSVLPPEINSFRMFSGAGSGPMLAAAAAWAGLADELGSAAAAFGSVTSGLAGGPGSAWQGPAAAAMAAVAAPYSGWLSAAAARAAGAAAQAQAVVGAFEAARAAVVHPLAVAANRNVFVQLVMSNLFGQNAPAIAAAEGVYEEMWAADVAAMVGYHGGVSAAAAQLASWSGSVAGLPGLSGLVGGVSGTGAAAGAPSALAAQATAGPAAVSQWLDDFVFNLGFGNIGSFNLGSGNIGGINLGSGNIGDTNLGSGNYGSQNWGGGNTGTANSGSGNIGDFNFGSGNFGSGNLGSGNIGSLNLGSGNFGTINIGSGNLADVSLGSGNTGDFNLGSGNLGGGNIGFGNLGTGNIGFGNKGNDNIGFGLTGNGQIGFGALNSGSNNIGLFNSGNNNIGFFNSGNNNIGWINSGNGNTGFGNAGDFNTGFWNAGSSNTGFGSAGSANFGIFDAGNGNFGSFNVGTHNTGFGNSGAGNTGFMNAGDSNTGAWNAGNVNTGFFNGGNTNTGGFNGGNLNTGFASAVDQPVLNSGFDNQGAGNSGFGNSDPNGTVNSGFFNTGIGNSGISNAGPALIPGFNSGFSNIGTNNAGFVNSGNTLAGISNSGDDSSGIVNSGDQNSGGFNSGSGISGFFR
>NC_022663.1|WP_023365621.1|1071550_1072945_-|glycine--tRNA-ligase
MRYRVASVIDTVVNLAKRRGFVYPSGEIYGGTKSAWDYGPLGVELKENIKRQWWRSVITSRDDVVGIDSSIILPREVWVASGHVEVFHDPLVESLITHKRYRADHLIEAYEAKHGHPPPNGLADIRDPDTGEPGQWTEPREFNMMLKTYLGPIETEEGLHYLRPETAQGIFINFANVVTTSRKKPPFGIGQIGKSFRNEITPGNFIFRTREFEQMEMEFFVEPSTAKEWHQYWIDTRLQWYVELGIDPQNLRLWEHPKEKLSHYSDRTVDIEYKFGFLGNPWGELEGVANRTDFDLSTHSKHSGTDLNFYDQVNDTRYTPYVIEPAAGLTRSFMAFLIDAYSEDEAPNAKGVMEKRTVLRLDARLAPVKAAVLPLSRHADLSPKARDLAAELRTCWNIEFDDAGAIGRRYRRQDEIGTPYCVTVDFDSLEDNAVTVRERDAMTQERIAIDKVADYLAVRLKGCC
>NC_022663.1|WP_023365623.1|1073136_1073529_+|winged-helix-turn-helix-transcriptional-regulator
MATSPATPVAVDDLVGHHEHGARSSSGHPASPAPPPREILDAAGELLRALAAPVRIAIVLQLRESQRCVHELVDALGVPQPLVSQHLKILKAAGVVTGERSGREVLYRLADHHLAHIVVDAVAHASEESP
>NC_022663.1|WP_023365625.1|1073525_1073918_+|transcriptional-repressor
MTGPSVRSTRQRAAISTLLETVDDFRSAQELHDELRRRGENIGLTTVYRTLQSMAAAGVVDTLRTDTGESVYRRCSEHHHHHLVCRSCGSTIEVADHEVEAWAAEVAARHGFSDVSHTIEIFGNCADCRS
>NC_022663.1|WP_023365627.1|1073995_1074445_-|hypothetical-protein
MPSLQQRLASILPDVLSVEQEPDGAMTVRHSGTFASLRVVSIAEGLELVSLTQILAWDLPLTRKIRERAAKQARDVNFGAVTVLEKSPDNGTAKGAAKTAAKTASKTGDVMLRYNFPGAGLSDDALRTLILLVLDTGVQVRDALIAGAR
>NC_022663.1|WP_036392649.1|1074444_1075338_-|decaprenyl-diphosphate-synthase
MAKKAERTLTSADFPQLPPAPDDYPTFPDTSTWPVVFPALPPSPDGGPRRPPQHISKAAAPRIPADRLPNHVAIVMDGNGRWATQRGLRRTEGHKMGEAVVIDIACGAIELGIKWLSLYAFSTENWKRSAEEVRFLMGFNRDVVRRRRENLKEMGVRIRWVGSRPRLWRSVINELAVAEQMTKYNDVITINYCVNYGGRTEIADATRQIAREVAAGRLNPERISESTISRYMQRPDIPDVDLFLRTSGEQRSSNFMLWQAAYAEYIFQDKLWPDYDRRDLWAACEEYASRNRRFGSA
>NC_022663.1|WP_036392645.1|1075330_1076128_-|DNA-repair-protein-RecO
MRLYRDRAVVLRQHKLGEADRIVTLLTRDHGLVRAVAKGVRRTRSKFGARLEPFAHIDAQLHPGRNLDIVTQVVSVDAFATDIVNDYGRYTCGCAMLETAERLAGEERAPAPALHRLTVGALRAVADGRRPRDLLLDAYLLRAMGIAGWAPALTECARCATPGPHRAFHIAAGGSVCAHCRPAGATTPPLGVLELMSALHDGDWAAAEQAPQSHRGYVSGLVAAHLQWHLERQLKTLPLVERTYRIDHTIAERRAALTRQVGECG
>NC_022663.1|WP_036392642.1|1076189_1077698_+|amidase
MVGASESASGAVSGSGNQRLPTLTDLLYQLANGSVTSVDLVRRSLREIQASQSTLNAFRVVFTESALADAAAADRRRAAGDTGPLLGIPIAVKDDVDVAGVPTAYGTEGYVAPATADSEVVRRLKAAGAVIVGKTNTCELGQWPFTSGPGFGHTRNPWARRHTPGGSSGGSAAAVAAGLVTAAIGSDGAGSIRVPAAWTHLVGIKPQRGRISTWPLPEAFNGITVNGVLARTVADAALVLDAASGNVEGDLHRPPPVTASDYVGIAPGPLKIALSTRAPFNGFRAKLHPEILAATRQVGEQLQLLGHTVVRGNPDYSVQMSWDFLARSTAGLWEWAQRLGDDVTLDPRTVSNLRTGHMLSQAILRSARRHEAAAHRRVGSIFDIVDVVLAPTTALPPPLARAFDQMGGLATDRAIIAACPYTWPWNLLGWPAINVPAGFTVEGLPIGVQLMGPANSEGMLISLAAELEAVSGWAAKQPTVWWNEGTDTPAPHSVRPPQRWQR
>NC_022663.1|WP_023365635.1|1077724_1078636_-|GTPase-Era
MTAEFRSGFVCLVGRPNTGKSTLTNALVGAKVAITSMRPQTTRHTIRGIVHRENFQIILVDTPGLHRPRTLLGKRLNDLVRATYAEVDVIGLCIPADEAIGPGDRWILEQIRSVAPGTTLVVIVTKIDKVPKDRVAAQLVAVGELVENLPGSTEIVPVSAVTGAQVDVLVDVLAGALPPGPAYYPDGELTDEPEEVLMAEFIREAALEGVHDELPHSLAVVIDDVSPRDGRDDLIDVHAVVYVERDSQKGIVIGKGGARLRQVGTAARGQIEKLLGTKVYLDLRVKVAKNWQRDPKQLGRLGF
>NC_022663.1|WP_036393017.1|1078632_1078953_-|hypothetical-protein
MAEPADPEDAKLVMLARAAMARAGADSGAAVRDHEGRTYVAVPVNLPALRLTGLQAAVAAAVSSGAIGLEAAALVAGSVDDPGIAALRELSPMAVVVVTDSTGTPL

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Crispr_ID: NC_022663_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022663_6

1533126-1533246

Orphan

Consensus_repeat	Method
GGCGGCGCAGGCGGCAACGGCGGAG	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_022663_6

>merge|NC_022663|6|1533126-1533246|CRISPRCasFinder
GATCCCCCTGGCGGCCACGGCGGACTACCGGCCGGCAACGGCGGCGCAGGCGGCAACGGCGGAGCCGGCGGCAAGGGTGCCGGCGACGGTATCCCGGGCGGCGCAGGCGGAAACGGCGGAG

>NC_022663|6|6|1533126-1533246|CRISPRCasFinder
GATCCCCCTGGCGGCCACGGCGGAC	TACCGGCCGGCAACGGCGGCGCA
GGCGGCAACGGCGGAGCCGGCGGCA	AGGGTGCCGGCGACGGTATCCCG
GGCGGCGCAGGCGGAAACGGCGGAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_022663.1\|WP_129111704.1\|1530423_1530858_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|119360
NC_022663.1\|WP_023366438.1\|1544645_1545746_+\|magnesium/cobalt-transporter-CorA	unknown	unknown	gnl\|CDD\|213364
NC_022663.1\|WP_023366432.1\|1540250_1541468_-\|NADP-dependent-malic-enzyme	unknown	unknown	gnl\|CDD\|223358
NC_022663.1\|WP_023366406.1\|1521761_1522901_-\|acyltransferase	unknown	unknown	gnl\|CDD\|224748
NC_022663.1\|WP_023366428.1\|1538462_1539296_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|235628
NC_022663.1\|WP_023366420.1\|1531092_1532874_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NC_022663.1\|WP_080674026.1\|1520064_1520874_+\|PPE-family-protein	unknown	unknown	gnl\|CDD\|366325
NC_022663.1\|WP_122503285.1\|1541715_1543386_+\|PE-family-protein	unknown	unknown	gnl\|CDD\|376422
NC_022663.1\|WP_023366397.1\|1518951_1519533_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NC_022663.1\|WP_099184961.1\|1547114_1547939_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_022663.1\|WP_129111703.1\|1525146_1525749_+\|DUF4190-domain-containing-protein	unknown	unknown	gnl\|CDD\|379388
NC_022663.1\|WP_023366414.1\|1526934_1530339_+\|TM0106-family-RecB-like-putative-nuclease	unknown	unknown	gnl\|CDD\|225160
NC_022663.1\|WP_023366424.1\|1533754_1534510_+\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_023366430.1\|1539402_1540254_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|270324
NC_022663.1\|WP_036392488.1\|1526160_1526757_+\|LppP/LprE-family-lipoprotein	unknown	unknown	gnl\|CDD\|379436
NC_022663.1\|WP_023366404.1\|1520963_1521680_-\|siderophore-interacting-protein	unknown	unknown	gnl\|CDD\|99790
NC_022663.1\|WP_023366436.1\|1543449_1544439_-\|malate-dehydrogenase	unknown	unknown	gnl\|CDD\|235468
NC_022663.1\|WP_023366440.1\|1545937_1547110_-\|sn-glycerol-3-phosphate-ABC-transporter-ATP-binding-protein-UgpC	unknown	unknown	gnl\|CDD\|236947
NC_022663.1\|WP_023366426.1\|1534695_1538385_+\|multifunctional-oxoglutarate-decarboxylase/oxoglutarate-dehydrogenase-thiamine-pyrophosphate-binding-subunit/dihydrolipoyllysine-residue-succinyltransferase-subunit	unknown	unknown	gnl\|CDD\|237030
NC_022663.1\|WP_023366408.1\|1522897_1524610_-\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|236941

Protein	Function_ID	Function_description	E-value
NC_022663.1\|WP_129111704.1\|1530423_1530858_-\|hypothetical-protein	gnl\|CDD\|119360	cd06543, GH18_PF-ChiA-like, PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in archaea but also in eukaryotes and prokaryotes. PF-ChiA exhibits hydrolytic activity toward both colloidal and crystalline (beta/alpha) chitins at high temperature.	2.01191e-61
NC_022663.1\|WP_023366432.1\|1540250_1541468_-\|NADP-dependent-malic-enzyme	gnl\|CDD\|223358	COG0281, SfcA, Malic enzyme [Energy production and conversion].	2.76337e-163
NC_022663.1\|WP_023366406.1\|1521761_1522901_-\|acyltransferase	gnl\|CDD\|224748	COG1835, COG1835, Predicted acyltransferases [Lipid metabolism].	3.77163e-51
NC_022663.1\|WP_023366428.1\|1538462_1539296_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|235628	PRK05855, PRK05855, SDR family oxidoreductase.	2.66916e-58
NC_022663.1\|WP_023366420.1\|1531092_1532874_-\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.99381e-80
NC_022663.1\|WP_080674026.1\|1520064_1520874_+\|PPE-family-protein	gnl\|CDD\|366325	pfam00823, PPE, PPE family. This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	6.75896e-61
NC_022663.1\|WP_023366436.1\|1543449_1544439_-\|malate-dehydrogenase	gnl\|CDD\|235468	PRK05442, PRK05442, malate dehydrogenase; Provisional.	0
NC_022663.1\|WP_122503285.1\|1541715_1543386_+\|PE-family-protein	gnl\|CDD\|376422	pfam00934, PE, PE family. This family named after a PE motif near to the amino terminus of the domain. The PE family of proteins all contain an amino-terminal region of about 110 amino acids. The carboxyl terminus of this family are variable and fall into several classes. The largest class of PE proteins is the highly repetitive PGRS class which have a high glycine content. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	2.55923e-24
NC_022663.1\|WP_023366397.1\|1518951_1519533_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	5.18498e-09
NC_022663.1\|WP_129111703.1\|1525146_1525749_+\|DUF4190-domain-containing-protein	gnl\|CDD\|379388	pfam13828, DUF4190, Domain of unknown function (DUF4190). This integral membrane domain is functionally uncharacterized. One of the membrane helices contains two GXXG motifs that are usually associated with dimerization.	0.000463041
NC_022663.1\|WP_023366414.1\|1526934_1530339_+\|TM0106-family-RecB-like-putative-nuclease	gnl\|CDD\|225160	COG2251, COG2251, Predicted nuclease (RecB family) [General function prediction only].	1.48017e-155
NC_022663.1\|WP_023366440.1\|1545937_1547110_-\|sn-glycerol-3-phosphate-ABC-transporter-ATP-binding-protein-UgpC	gnl\|CDD\|236947	PRK11650, ugpC, sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC.	0
NC_022663.1\|WP_023366430.1\|1539402_1540254_-\|hypothetical-protein	gnl\|CDD\|270324	cd13606, PBP2_ProX_like, Bacterial substrate-binding protein ProX of ABC-type osmoregulated transporter and its related proteins; the type 2 periplasmic-binding protein fold. This group includes periplasmic substrate-binding component of ABC transport systems from gram-negative and -positive bacteria that are involved in uptake of osmoprotectants (also termed compatible solutes) such as betaine, choline, proline betaine, carnitine, and L-proline. To counteract the efflux of water, many microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	3.77685e-42
NC_022663.1\|WP_036392488.1\|1526160_1526757_+\|LppP/LprE-family-lipoprotein	gnl\|CDD\|379436	pfam14041, Lipoprotein_21, LppP/LprE lipoprotein. The family includes putative lipoproteins LppP and LprE from species of Mycobacterium. LppP is required for optimal growth of M. tuberculosis.	1.97503e-12
NC_022663.1\|WP_023366404.1\|1520963_1521680_-\|siderophore-interacting-protein	gnl\|CDD\|99790	cd06193, siderophore_interacting, Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from transferrin and lactoferrin for bacterial uptake, contributing to pathogen virulence. Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport mechanism of photosystem I. FNR transfers electrons from reduced ferredoxin to FAD (forming FADH2 via a semiquinone intermediate) and then transfers a hydride ion to convert NADP+ to NADPH. FNR has since been shown to utilize a variety of electron acceptors and donors and has a variety of physiological functions including nitrogen assimilation, dinitrogen fixation, steroid hydroxylation, fatty acid metabolism, oxygenase activity, and methane assimilation in a variety of organisms. FNR has an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) flavin sub-domain which vary in orientation with respect to the NAD(P) binding domain. The N-terminal moeity may contain a flavin prosthetic group (as in flavoenzymes) or use flavin as a substrate. Because flavins such as FAD can exist in oxidized, semiquinone (one-electron reduced), or fully reduced hydroquinone forms, FNR can interact with one and two electron carriers. FNR has a strong preference for NADP(H) vs NAD(H).	7.66149e-49
NC_022663.1\|WP_023366408.1\|1522897_1524610_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|236941	PRK11634, PRK11634, ATP-dependent RNA helicase DeaD; Provisional.	2.44414e-174
NC_022663.1\|WP_099184961.1\|1547114_1547939_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	8.25896e-75
NC_022663.1\|WP_023366438.1\|1544645_1545746_+\|magnesium/cobalt-transporter-CorA	gnl\|CDD\|213364	cd12830, MtCorA-like, Mycobacterium tuberculosis CorA-like subfamily. This bacterial subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes the Mg2+ transporter Mycobacterium tuberculosis CorA (which also transports Co2+). Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.	1.41352e-164
NC_022663.1\|WP_023366426.1\|1534695_1538385_+\|multifunctional-oxoglutarate-decarboxylase/oxoglutarate-dehydrogenase-thiamine-pyrophosphate-binding-subunit/dihydrolipoyllysine-residue-succinyltransferase-subunit	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	0

>NC_022663.1|WP_023366420.1|1531092_1532874_-|MFS-transporter
MTTATSRMPAASYSGSPWNALWSMMIGFFMIMLDSTIVAIANPTIMAVLHVGYATVVWVTSAYLLGFAVVLLVAGRLGDRFGPKNLYLTGLAVFTAASMWCGLSGSAGALITARVVQGVGAGLLTPQTLSIITRTFPAARRGVAMSMWGATAGVASLVGPLAGGALVGGLGWEWIFFVNIPIGVLGLALAAWLVPVLPVRAQRFDLIGVALSGIGMFLLVFGLQEGPSAGWQPWIWAVLVAGLGFMSAFVYWQSLNRHAPLIPLEIFRDRDFSLCTVGVAITAFATTAMMLPLIFYAQSVCGLSPIRAALLIAPVAISSGVLAPFVGRIVDTSHPLPVVGFGFSALAIAMTWLSIEMEPDTPVWRLVLPFCAIGVGMAFVWSPLAATATRNLRPDQAGASSGVYNATRQIGAVLGSASMAAFMTSRISAEMPPPPDGAPGFGGEGGGLQLPEFVRAPFSAAMSQSMLLPAFIALFGIVAALFLVGGTGATASRRLLPQGDHGDDYQESDEDFDDDDYVEYILQPEPDRWHRSDGEIPWAYRQSCGEPVDVPSDVVRNGSHIDSSPQTSTPSLLGSGQSAYRAHYLDDPHGPAG
>NC_022663.1|WP_129111704.1|1530423_1530858_-|hypothetical-protein
MRVSFTLTVLPTGLTADGLRVVQNAIANGVDIGQVDVMAMDYDDPAFDYSGKMGDLAIQAAQRVHDQLAPLYPSKSDTQVWAMVGVTPMIGVNDDPREVFTVADADKLTAFARQKGLGRLAMWSANRDSQCPAELRNRRTRAAV
>NC_022663.1|WP_023366414.1|1526934_1530339_+|TM0106-family-RecB-like-putative-nuclease
MFLSDDTLVYSASDLASAARCEYALLRDFDAKLGRGPAAPVADELLARAAVLGNEHERRRLDRLRDEFGDGVAVIGRPAYTLAGLTAAAAATRHAIANHARVVYQAALFDGRFVGFADFLIRDGERYRIADTKLARSPQVTALLQLAAYADALAGCGVPVAPEAELELGDGTVVRYRISDLIPVYRSQRAVLQRLLDNHYASGTAVCWDDPGVRACFRCPLCTEQLRATDDLLLVAGMRVTQREKLLDAGITTIDKLAEHTQPVPGLAPSVLGKLTAQAKLQVRQRNTGEPQYEIVDPQPLALLPEPDAGDLFFDFEGDPLWTADGHEWGLEYLFGVLEAGPAGAFQPLWAHDRAQERQALKDFLALVAKRRRRHPNMHIYHYAPYEKTALLRLAGRYGVGEDDIDELLRNGVLVDLYPLVRKSLRAGAESFSLKALEPLYMGARLRAGEVTTAADSITCYARYCDLRAEGCTDEAAAVLKEIEDYNHYDCRSTRELRDWLLMRAWEAGVTPIGVQPVADSGRVEDHDELAAALATFVGDDAATNRTPEQNVVALLSAARGYHRREDKPFWWGHFDRLNYPLDEWSDSTDVFVADETSVVAAWHTPARARKPQRRVRLTGGLARGDLKTSVFALYNPPAPPGISDDPDRRAAGHAEVVGVDDPGLPTEVVILERTGSDGNTFEQLPFALTPGPPVPTTVLRKSIEATASAVAGGLPRLPRTALVDVLLRHPPRTRLPRGTDIVADITVAVLGLDASYVAVHGPPGTGKTHTAARVIKRLVVEHSWRIGVVAQSHAAVENLLDCVIDADLDPGCVAKKKYDRTAPRWQQIDEKHYPAFIADHAGCVIGGTAWDFANEQRVPRGSLDLLVIDEAGQFSLANTIAVAPAATNMLLLGDPQQLPQVSQGTHPEPVDASALDWLVDGQRTLPDERGYFLDRSYRMHPAVCAAVSMLSYEGRLQSHAACTTARRVAGYQPGVHALSVAHQGNSIECPEEAEAILAEILALLGRSWSDERGTRPLAASDLLVLAPYNAQVGLLRQRLRSAGLDGIRVGTVDKFQGGQAPVVFISMTASSADDVPRGMSFLLNRNRLNVAISRAQYAAVVVRSEILTQYLPTTPAGLIDLGAFLALTSRPPP
>NC_022663.1|WP_036392488.1|1526160_1526757_+|LppP/LprE-family-lipoprotein
MWSLPRRAAPLIGVSATALVAATLTGCGSGDSTVAKTPQATTPPVAASSASSPTTPSSAAALPPTSSAAPADPCAVNLASPAIVRVVSELPRDPRSQQPWNPEPLAGNYNECAQLSAVIVKANTNDTNPTTRAVMFHLGQFIKQGVPDTYGFTGVDESQSTGDTVALTYSGGITGLNSLVKFRWNGSGVEVLGNTPGG
>NC_022663.1|WP_129111703.1|1525146_1525749_+|DUF4190-domain-containing-protein
MTALLCGVFGSCLGLVPALGIAAFPFAVVGLACGVIAMIRASKGVRAGKAMAIAGTLLCVLALILATFWIVVIANSFKDRGDSRKAITGQSTEDILRNDLDVQFGQFVTDDNPDRSGKMIVTLRNKSNKSASFSVDVEALDASGNRIAGDTAFVEVLAPGQATRKDMFVFVASDKHDAMKKATFRVVEASKYAPMPPPVK
>NC_022663.1|WP_023366408.1|1522897_1524610_-|DEAD/DEAH-box-helicase
MLTPDNMPVAPPDTFVDLQIHPSVLRAIAGVGYESPTAIQAATIPALMAGSDVVGLAQTGTGKTAAFAIPILSKIDVTSTATQALILAPTRELALQVAEAFSRYGAYLPKLNVLPIYGGSSYAVQLAGLRRGAQIIVGTPGRVIDHLERGTLDLSRVDYLVLDEADEMLAMGFAEDVERILSDTPEYKQVALFSATMPPAIRKITTKYLHDPLEVTSKAKTATAENISQRYIQVAGPRKMDALTRVLEVEPFEAMIVFVRTKQATEEVAEKLRARGFSAAAINGDIPQQQRERTITALREGGPNGIDILVATDVAARGLDVERISHVLNYDIPHDTESYVHRIGRTGRAGRPGAALLFVSPRERHLLKAIEKATRQTMTEAELPTVEDVNAQRVAKFSDSITDALAKPGVALFRKLVEDYEREHDVPMADIAAALALQSRDGEAFLLAPEPPPERRSETKKPASDQHAEKRRNGPALSTYRISVGKRHKIGPGAIVGAIANEGGLHRSEFGHISIGPDFSLVELPAKLPRATLKKLESTRISGVLINLRRDGPVKASRYDRGKPRRKRIG
>NC_022663.1|WP_023366406.1|1521761_1522901_-|acyltransferase
MTLSKAEDDQGGLEQISHVDRVASLTGIRAVAALLVVGTHAAYSTGKYTHGYWGLVSSRMEIGVPIFFVLSGYLLFRPWVRSAATDGPPPSLSRYAWHRVRRIMPAYVVVVLIAYVIYHFRTAGPNPGHSWMGLVRNLTLTQIYTDGYLGSYLHQGLTQMWSLAVEAAFYVALPFLAYVLLVLVSRRRWQPRLMVGALAGMATITPVWLVLIHTVGWFPDGARLWLPSYLAWFLGGMMLTVLQAMGVRCYAFAALPLAVICYFIASTPIAGAPTTSPSAVTEAVVKACFYAVIATLAVAPLALGDQGWYSRLLASRPMVWLGEISYEIFLVHLVTMEFAMVHVVRYRVYTGSMLNLFIATMVVTIPVAWLLHRFTRVKT
>NC_022663.1|WP_023366404.1|1520963_1521680_-|siderophore-interacting-protein
MTEHKASRGWQGAVLKLMRAGDYRLTVTGWREISPHYLRLSFDDGGMLGEHAVHPTMWIRMWFSDGDKSHQRGYTLVDPDPAAGAFDVEFALHEGIASDWARNAQPGDTIDATVLGSKFAIPDPPPGGYVIVGDTASLPAINSLLESIGEAPARVFLEAGYDEDKSLPVARTDDVTWVDRKDDGNALLETVRGAAFDAGDHFGWVASSTRTTRSVAKALREDFGIPRKSIKAQAYWMA
>NC_022663.1|WP_080674026.1|1520064_1520874_+|PPE-family-protein
MSYAMFPPEVNSALLCSGAGSGPMLTAATAWGELAGELRSAAASFASVTSDLACGAWQGAAAAKMTEAAAPYAAWLATAASHSEGAACQAGAVVAAFEAACAATVSPVIIAANRAITRALANTNIFGFNMPAIAAMEAEYEEMWARDVSAMFGYHVGVSQAWSQLFPIQQLLRGLPRIPIPPCGTPPTTTPPPTTPPPTTPPPVTPPPPTTPPPVTPPPPTTPPPTTPPVTPPPPPRPTPPPTPTPRPVPPIHRVPVEPRIPTVPVMRK
>NC_022663.1|WP_023366397.1|1518951_1519533_+|TetR/AcrR-family-transcriptional-regulator
MAGTDWLAARRTEVAADRILDAAAQLYTVRDPASIGMNEIARAAGCSRATLYRYFDSREALRTAYVHRETRRLGREIMQQISGVEDPQERLVASIAATLRMVRESPALAAWFAATRPPIGGELAGQSEVIAALAAAFLQSLGSVGGAAVERRARWAVRVIISLLTFPGRDEADERAMIEDFVVPVVAPVSASP
>NC_022663.1|WP_023366424.1|1533754_1534510_+|hypothetical-protein
MSARRTKRSDPDEQPAATGRPKASSRALAQVIERSAHVQAPAAEAYVARLRRAHPAAGPAEIVAKIEKRFVAAVTASGAAIGIVATLPGIGTLAALLAAAGETAVFLEATALLVLALASVYGIPLDHRERRRALVLAVLVGDNSKSAVAELMGSGRTSGGWVSESVASLPLPAVSKFNTRMFKYFAKRFALKRGALMFGKLLPAGIGAVIGAIGNRLVGKKLVRNARSAFGAPPARWPVTLYVLPTVRDAS
>NC_022663.1|WP_023366426.1|1534695_1538385_+|multifunctional-oxoglutarate-decarboxylase/oxoglutarate-dehydrogenase-thiamine-pyrophosphate-binding-subunit/dihydrolipoyllysine-residue-succinyltransferase-subunit
MANISSPFGQNEWLVEEMYRKFRDDPSSVDPSWHEFLVDYNPEPAQSAPADNQQVATAPPPEPVRPAAEPVRPATKPAGAAGAGNGSPAAAPTKAAAPPPAEGDELQVLRGAAAAVVKNMSASLDVPTATSVRAVPAKLLIDNRIVINNQLKRNRGGKISFTHLLGYALVQAVKQFPNMNRHYTEVDGKPNVVTPAHTNLGLAIDLQGKDGKRSLVVAGIKRCETMRFAQFVTAYEDIVRRARDGKLTAEDFAGVTISLTNPGTIGTVHSVPRLMAGQGAIIGVGAMEYPAEFQGASQERIAELGIGKLITLTSTYDHRIIQGAESGDFLRTIHQMLLADDFWDEIFRELGIPYLPVRWRSDNPDSIVDKNPRVIELIAAYRNRGHLMADIDPLRLDKTRFRSHPDLDVCSHGLTLWDLDRLFKVDGCFGGSPYMKLRDVLSILRDAYCRHVGVEYTHILEPEQQQWLQQRVEAKHVKPTVAQQKYILSKLNAAEAFETFLQTKYVGQKRFSLEGAESVIPMMDAAIDQCAEHGLDEVVIGMPHRGRLNVLANIVGKPYSQIFTEFEGNLNPSQAHGSGDVKYHLGATGVYLQMFGDNDIQVSLTANPSHLEAVDPVLEGLVRAKQDLLDSDGEQRFSVVPMMLHGDAAFAGQGVVAETLNLTNLPGYRVGGTIHIIVNNQIGFTTAPEYSRSSEYCTDVAKMIGAPIFHVNGDDPEACEWVARLAVDFRQEFHKDVVIDMLCYRRRGHNEGDDPSMTNPYMYDVVDTKRGARKSYTEALIGRGDISLKEAEDALRDYQGQLERVFNEVRELEKHAVQPSMSVESEQQVPRGLATAVDKALLARIGDAFLAFPDGFTPHPRVQPVLEKRREMAYEGKIDWAFAELLALGSLVAEGKLVRLSGQDTRRGTFSQRHSVIIDRNTGKEFWPLQLLATNKDGTPTGGKFLVYDSPLSEYAAVGFEYGYTVGNPDALVLWEAQFGDFVNGAQSIIDEFISSGEAKWGQLSNVVLLLPHGHEGQGPDHTSGRIERFLQLWAEGSMTIAVPSTPSNYFHLLRRHALDGIMRPLIVFTPKSMLRNKAAVSDIKDFTEIKFRSVLEEPTYEDGIGDRSKVRRILLTSGKIYYELAARKAKDNRDDIAIVRIEQLAPLPKRRLNETLDRYPNATEFFWVQEEPANQGAWPRFGLELPELLPDKLTGLKRISRRAMSAPSSGSSKVHAVEQQEILDTAFG
>NC_022663.1|WP_023366428.1|1538462_1539296_+|SDR-family-NAD(P)-dependent-oxidoreductase
MEGFAGKVAVVTGAGSGIGRALALELGRSGASLAISDVDSDGLAQTEEMLKAIGAPVKADRLDVTEREAVLAYADAVNEHFGKVNQIYNNAGIGHTGDVEVCEFKDIDRVMDVDFGGVLNGTKAFLPYLIASGDGHVINISSVFGLFSCAGQAAYNAAKFAVRGFTEALRQEMILAGHPVGVTTVHPGGIKTAIARNATAAEGLDAAELAKLFDKRAARTSPERAAKVILDAVRKNKARVLVGPDAKVLDLVVRVTGSGYQRLFMPLFGKLIPAPHR
>NC_022663.1|WP_023366430.1|1539402_1540254_-|hypothetical-protein
MRIGRLAPLLLAAVLAVAGCAAGAGKRPAELVVGSRPDTESMLLADIYVAALRSYGFAARGDTAADPMTNLDAGAFAVVPAFTGQVLQSLQPGASARSDKSVYQAMVAALPEGVAAGDYATAAEDKPALVVTPATSTAWGGSELDLLPRHCDGLVVGMLTGAHPPAAVGSCRLPTPREFADYPAMLTALRAGQLTAGWTTTANPANPADLVVLNDGKDALIQAENVVPLYRRNTLTDRQRLAINEVAGVLDTAALVEMRRQVAGGADPQAVAAAWLGEHPLGR
>NC_022663.1|WP_023366432.1|1540250_1541468_-|NADP-dependent-malic-enzyme
MAVSNVEPLAAHSSSASGPQVAIRSDEIFAAHVGGKLSVALKSPLDTQRALSIAYTPGVAQVSRAIAADRTLTARYTWANRLVAVVSDGSAVLGLGDIGPAASLPVMEGKCALFQAYGGLNAIPIVLDTKDPDEIVETLVRLRPTFGAVNLEDISAPRCFEIERRLVEALDCPVMHDDQHGTAIVVLAALMGATKLLGRDMSSLRVAVSGAGAAGVACTNLLLAMGVSDITVLDSRGILHTGRDDMNSVKVEMAQRTNPDGRTGGLVEALDGADVFLGVSAGVVPEELIATMAADGIVFALSNPDPEIHPEVAAKYATVVATGRSDFPNQINNVLAFPGVFRGALDAGARQITEKMMVAAAEAIYSVVSDDLALDRIVPSPLDSRVGDAVAKAVALAVEPSDTAG
>NC_022663.1|WP_122503285.1|1541715_1543386_+|PE-family-protein
MAIPELLASTATDLERIGSRLSAVNATAVGPTTVLVSAGSDEVSAAVASLFSRHAQEYQAWSARVSTFHAHFVQTLTTGAGMYHAAEAANVSPLQQTLDVVNAPTQLLLGRPLIGNGANGGPGQNGGNGGLLYGDGGNGGSSTTPGQPGGNGGAAGLVGNGGAGGAGGAGANGGAGGNGGLFYGNGGAGGAGGAASIVGGNGGNGGAGGNAGLWGDGGAGGAGAAGATGADAVNPGYHQVQRAPIGDPGHNNTNGNGGNAGDGDNGVNPGIGGGDGGPGGDGTANGAVSGGAAGAGGAGGTFASGGDGGVGGAATNNGAGDTRGGAGGAGGAGGAGGAGGDGGTGGDATTTTGIGTVFGGAGGTGGAGGVGAPGGTGGNGGAATQAGGLAYGGDGGDGGPGGVGASAAAGGAGGFGGAGGRGGLLFGTGGAGAVGGVGGNGGIGANGSYGGDGGDGGAAGGTGGPLNTGLAGNGGDGGDGGAGGAGGAGGNGGAAGAAGLFGQSGSPGAGAAGGLGGSGGVGGTGGAGGIGLNLGNPGTPGSQGATGANGQHGLDG
>NC_022663.1|WP_023366436.1|1543449_1544439_-|malate-dehydrogenase
MSASPLKVAVTGAAGQIGYSLLFRLASGSLLGPDRSIELRLLEIEPALKALEGVVMELDDCAFPLLAGVEIGADANKIFDGVNLALLVGARPRTKGMERGDLLEANGAIFTAQGKALNEVAAADVRVGVTGNPANTNALIAMSNAPDIPRERFTALTRLDHNRAISQLAKKTGVKVTDIKKMTIWGNHSATQYPDVFHAEIGGKNAAEVVGDQAWIENDFIPTVAKRGAAVIEARGASSAASAASATIDAARDWLLGTPADDWVSMAVLSDGSYGVPEGLISSFPVTTKDGDWTIVSGLEIDEFSRGRIDKSTAELADERSAVTELKLI
>NC_022663.1|WP_023366438.1|1544645_1545746_+|magnesium/cobalt-transporter-CorA
MFQGFDALPESLRTVARSRPQHVHPTPSSPAQALVDCGVYVDGRRMPGKYAYTDAVREVRERELEGEQAFVWIGLHEPNHHQMQDVADVFGLHPLAVEDAVHAHQRPKLERYDETLVLVLKTVNYVPHDSVVLAREIVETGEIMIFVGDDFVITVRHGEHGGLSDVRNRMDADPQHLRLGPYAVMHAIADYVVDHYLAVTSLIETDIDSIEEVAFAPGSKLDVEPIYLLKREVLELRRCVNPLSAAFQRMQTENKDLISKEVRRYLRDVADHQTEAAEQIASYDDMLNSLIQAALARVGMQQNMDMRKISAWAGIIAVPTMIAGIYGMNFHFMPELDSRWGYPAVISSMVLVCLFLYLSFRNRNWL
>NC_022663.1|WP_023366440.1|1545937_1547110_-|sn-glycerol-3-phosphate-ABC-transporter-ATP-binding-protein-UgpC
MAEIVLEHVSKSYPNGAAAVDDLSLTIADGEFLILVGPSGCGKTTTLNMIAGLEDISSGELRIDGQRVNEKAPKDRDIAMVFQSYALYPHMTVRQNIAFPLTLAKMKKADIAQKVSETAKILDLTDLLDRKPSQLSGGQRQRVAMGRAIVRHPKAFLMDEPLSNLDAKLRVQMRGEIARLQKRLGTTTVYVTHDQTEAMTLGDRVVVMHGGVAQQIGTPTELYEHPANVFVAGFIGSPTMNFFPATLTSIGLTLPFGEVTLAPEVQQLIAARAKTENIIVGVRPEHLQDAALIDAYQRIKALTFQVGVDLVESLGADKYVYFTTSAPAVHSAQLDELEAQGEMRENQFAARVSAESKAAIGQSLELAFDTTKLAVFDADSGVNLTIPVVG
>NC_022663.1|WP_099184961.1|1547114_1547939_-|carbohydrate-ABC-transporter-permease
MSARRTMAWAIIDVLVVVYALLPVLWIFSLSLKPTSTVKDGKLIPASVTLDNYRGVFRGEFFSSALINSIGVGLITTVIAVLLGAMAAYAVARLAFPGKRVLIGATLLITMFPAISLVTPLFNIERAVGLFDTWPGLILPYITFALPLAIYTLSAFFREVPWDLEKAAKMDGATPGQAFRKVIAPLAAPGLVTAAILVFIFAWNDLLLALSLTATKAAITAPVAIANFTGSSQFEEPTGSIAAGAMVITVPIIVFVLVFQRRIVAGLTSGAVKG

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Crispr_ID: NC_022663_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022663_7

1762915-1763970

Orphan

Consensus_repeat	Method
NCCGGCGGNNNCGGCGGN	CRT

19 spacers

The CRISPR arrays of NC_022663_7

>merge|NC_022663|7|1762915-1763970|CRT
AACGGCGGTGCCGGGGGGTCCGGAGCCACCGGCGCCAACGGCGGAGCCGGCGGCACCGGCGGGGCCGCAGGGCTGATCGGCAACGGCGGGGCCGGCGGGGCCGGCGGATCCGCCACCACCGGCACCGGCGGCGCCGGCGGCAACGGCGGCAATGCGGGGCTGTTCGGCGCCGGCGGGGCCGGCGGGGCCGGCGGGGGCTCGATCCAGGGGGCCGGCGGGACCGGTGGGTCCGGCGGCAACGCCGGCACGCTCTTCGGCGCGGCCGGGACCGGCGGCGCCGGCGGGTTCACCCAGAGCAACACCGCGCTCGGTGGGACGGGCGGCGCCGGCGGGGCCGGTGGGCTGTTCTCCAGCGGCGGCGCGGGAGGGGCCGGCGGATTCAGCGAGGCCGGGACCGGCGGGACCGGCGGCGCCGGCGGGACCGGCGGAATGTTCGGCCCCGCCGGCACCGGAGGGGTCGGCGGAGAGAGCTTGGGCGGCAACGGCGGAGTCGGCGGGGCCGGCGGGGCCGGCGGGATGTTCGGCGCGGGTGGCACCGGTGGCAGCGGCGGGCACGGCGCAACCAGCGGTGGCATGGGTGGGACCGGCGGCAACGCCGGCATGCTCAGCCTCGGTGCGGCCGGCGGCGCCGGCGGCGCCGGCGGGGAAGGTGTCACCCCGGGCGGACTCGGCGGGGCGGGCGGAGCCGGCGGCACCGGCGGCATGTTCTTCGGCGACGGCGGGGCCGGCGGCAACGGCGGATTCGGCGCCACGAACGGCGGCAAAGGTGGCACCGGCGGCAACGCCGGCATGCTTGCCGGCTCCGGTGGTGCCGGCGGCGCCGGCGGGCAGGGTGGTACGACGGCCGGCGGTAACGGCGGCGCGGGCGGCAGCTCCGGGATGATCGGTGACGGCGGCAATGGCGGTAGCGGCGGCGCTGGCGGGACCGGCGCCGGTGGTAAGGGCGGTAGCGGCGGCGCCGGCGGCAACGGCGTGTTGATCGGCGACGGCGGCAACGGCGGCAATGGCGGGACCGGCACCGTCCCGGGCAAGGCCGGCGCCGGCGGTATCGGCGGC

>NC_022663|7|1|1762915-1763970|CRT
AACGGCGGTGCCGGGGGG	TCCGGAGCCACCGGCGCCAACGGCGGA
GCCGGCGGCACCGGCGGG	GCCGCAGGGCTGATCGGCAACGGCGGG
GCCGGCGGGGCCGGCGGA	TCCGCCACCACCGGCACCGGCGGCGCCGGCGGCAACGGCGGCAATGCGGGGCTGTTCGGC
GCCGGCGGGGCCGGCGGG	GCCGGCGGGGGCTCGATCCAGGGG
GCCGGCGGGACCGGTGGG	TCCGGCGGCAACGCCGGCACGCTCTTCGGCGCGGCCGGG
ACCGGCGGCGCCGGCGGG	TTCACCCAGAGCAACACCGCGCTCGGTGGG
ACGGGCGGCGCCGGCGGG	GCCGGTGGGCTGTTCTCC
AGCGGCGGCGCGGGAGGG	GCCGGCGGATTCAGCGAGGCCGGGACCGGCGGG
ACCGGCGGCGCCGGCGGG	ACCGGCGGAATGTTCGGC
CCCGCCGGCACCGGAGGG	GTCGGCGGAGAGAGCTTGGGCGGCAACGGCGGAGTCGGCGGG
GCCGGCGGGGCCGGCGGG	ATGTTCGGCGCGGGTGGC
ACCGGTGGCAGCGGCGGG	CACGGCGCAACCAGCGGTGGCATGGGTGGG
ACCGGCGGCAACGCCGGC	ATGCTCAGCCTCGGTGCG
GCCGGCGGCGCCGGCGGC	GCCGGCGGGGAAGGTGTCACCCCGGGCGGACTCGGCGGGGCGGGCGGA
GCCGGCGGCACCGGCGGC	ATGTTCTTCGGCGACGGCGGG
GCCGGCGGCAACGGCGGA	TTCGGCGCCACGAACGGCGGCAAAGGTGGC
ACCGGCGGCAACGCCGGC	ATGCTTGCCGGCTCCGGTGGTGCCGGCGGCGCCGGCGGGCAGGGTGGTACGACG
GCCGGCGGTAACGGCGGC	GCGGGCGGCAGCTCCGGGATGATCGGTGACGGCGGCAATGGCGGTAGCGGCGGCGCTGGCGGGACCGGC
GCCGGTGGTAAGGGCGGT	AGCGGCGGCGCCGGCGGCAACGGCGTGTTGATCGGCGACGGCGGCAACGGCGGCAATGGCGGGACCGGCACCGTCCCGGGCAAGGCCGGC
GCCGGCGGTATCGGCGGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_022663.1\|WP_080674035.1\|1752061_1752658_+\|SHOCT-domain-containing-protein	unknown	unknown	gnl\|CDD\|378276
NC_022663.1\|WP_160937993.1\|1769433_1771059_+\|pyruvate,-phosphate-dikinase	unknown	unknown	gnl\|CDD\|235635
NC_022663.1\|WP_036445312.1\|1768124_1768739_+\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_036444322.1\|1759007_1762328_+\|LuxR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|226418
NC_022663.1\|WP_036392726.1\|1743731_1746011_+\|5-methyltetrahydropteroyltriglutamate---homocysteine-S-methyltransferase	unknown	unknown	gnl\|CDD\|235367
NC_022663.1\|WP_160937641.1\|1773457_1774687_-\|DUF1298-domain-containing-protein	unknown	unknown	gnl\|CDD\|274360
NC_022663.1\|WP_023366831.1\|1771970_1772780_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377946
NC_022663.1\|WP_051404574.1\|1766844_1767075_-\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_036392710.1\|1765303_1766839_-\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|224875
NC_022663.1\|WP_023366792.1\|1749351_1750092_+\|PPE-family-protein	unknown	unknown	gnl\|CDD\|366325
NC_022663.1\|WP_080674034.1\|1748082_1748673_-\|twin-arginine-translocation-signal-domain-containing-protein	unknown	unknown	gnl\|CDD\|226042
NC_022663.1\|WP_023366786.1\|1746288_1748025_-\|DUF3556-domain-containing-protein	unknown	unknown	gnl\|CDD\|371888
NC_022663.1\|WP_036392707.1\|1767236_1768022_-\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|376615
NC_022663.1\|WP_036392713.1\|1756914_1758681_-\|PPE-family-protein	unknown	unknown	gnl\|CDD\|366325
NC_022663.1\|WP_042313446.1\|1752781_1754128_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224152
NC_022663.1\|WP_023366837.1\|1774706_1775612_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|235628
NC_022663.1\|WP_023366823.1\|1768779_1769289_-\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|225168
NC_022663.1\|WP_023366804.1\|1754295_1755861_-\|PE-family-protein	unknown	unknown	gnl\|CDD\|376422
NC_022663.1\|WP_036445318.1\|1772851_1773454_+\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_036392442.1\|1750151_1751864_-\|IS1634-family-transposase	unknown	unknown	gnl\|CDD\|227708

Protein	Function_ID	Function_description	E-value
NC_022663.1\|WP_080674035.1\|1752061_1752658_+\|SHOCT-domain-containing-protein	gnl\|CDD\|378276	pfam09851, SHOCT, Short C-terminal domain.	1.86288e-08
NC_022663.1\|WP_160937993.1\|1769433_1771059_+\|pyruvate,-phosphate-dikinase	gnl\|CDD\|235635	PRK05878, PRK05878, pyruvate phosphate dikinase; Provisional.	0
NC_022663.1\|WP_036444322.1\|1759007_1762328_+\|LuxR-family-transcriptional-regulator	gnl\|CDD\|226418	COG3903, COG3903, Predicted ATPase [General function prediction only].	6.32e-114
NC_022663.1\|WP_036392726.1\|1743731_1746011_+\|5-methyltetrahydropteroyltriglutamate---homocysteine-S-methyltransferase	gnl\|CDD\|235367	PRK05222, PRK05222, 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional.	0
NC_022663.1\|WP_160937641.1\|1773457_1774687_-\|DUF1298-domain-containing-protein	gnl\|CDD\|274360	TIGR02946, Putative_diacyglycerol_O-acyltransferase_Mb3115, acyltransferase, WS/DGAT/MGAT. This bacteria-specific protein family includes a characterized, homodimeric, broad specificity acyltransferase from Acinetobacter sp. strain ADP1, active as wax ester synthase, as acyl coenzyme A:diacylglycerol acyltransferase, and as acyl-CoA:monoacylglycerol acyltransferase. [Unknown function, Enzymes of unknown specificity].	6.32762e-22
NC_022663.1\|WP_023366831.1\|1771970_1772780_+\|hypothetical-protein	gnl\|CDD\|377946	pfam07947, YhhN, YhhN family. The members of this family are similar to the hypothetical protein yhhN expressed by E. coli. Many are annotated as possible transmembrane proteins, and in fact they all have a high proportion of hydrophobic residues. A human member of this family, formerly known as TMEM86B, is a lysoplasmalogenase that catalyzes the hydrolysis of the vinyl ether bond of lysoplasmalogen. Putative conserved active site residues have been proposed for the YhhN family.	0.00176289
NC_022663.1\|WP_036392710.1\|1765303_1766839_-\|radical-SAM-protein	gnl\|CDD\|224875	COG1964, COG1964, Predicted Fe-S oxidoreductases [General function prediction only].	1.27978e-30
NC_022663.1\|WP_023366792.1\|1749351_1750092_+\|PPE-family-protein	gnl\|CDD\|366325	pfam00823, PPE, PPE family. This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	2.65318e-56
NC_022663.1\|WP_080674034.1\|1748082_1748673_-\|twin-arginine-translocation-signal-domain-containing-protein	gnl\|CDD\|226042	COG3511, PlcC, Phospholipase C [Cell envelope biogenesis, outer membrane].	1.75337e-44
NC_022663.1\|WP_023366786.1\|1746288_1748025_-\|DUF3556-domain-containing-protein	gnl\|CDD\|371888	pfam12077, DUF3556, Transmembrane protein of unknown function (DUF3556). This family of transmembrane proteins is functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 576 to 592 amino acids in length.	0
NC_022663.1\|WP_036392707.1\|1767236_1768022_-\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|376615	pfam01790, LGT, Prolipoprotein diacylglyceryl transferase.	2.31982e-33
NC_022663.1\|WP_036392713.1\|1756914_1758681_-\|PPE-family-protein	gnl\|CDD\|366325	pfam00823, PPE, PPE family. This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	5.678e-81
NC_022663.1\|WP_042313446.1\|1752781_1754128_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|224152	COG1231, COG1231, Monoamine oxidase [Amino acid transport and metabolism].	2.52663e-73
NC_022663.1\|WP_023366837.1\|1774706_1775612_-\|alpha/beta-hydrolase	gnl\|CDD\|235628	PRK05855, PRK05855, SDR family oxidoreductase.	1.29585e-18
NC_022663.1\|WP_023366823.1\|1768779_1769289_-\|DoxX-family-protein	gnl\|CDD\|225168	COG2259, COG2259, Predicted membrane protein [Function unknown].	1.38698e-22
NC_022663.1\|WP_023366804.1\|1754295_1755861_-\|PE-family-protein	gnl\|CDD\|376422	pfam00934, PE, PE family. This family named after a PE motif near to the amino terminus of the domain. The PE family of proteins all contain an amino-terminal region of about 110 amino acids. The carboxyl terminus of this family are variable and fall into several classes. The largest class of PE proteins is the highly repetitive PGRS class which have a high glycine content. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	1.92916e-25
NC_022663.1\|WP_036392442.1\|1750151_1751864_-\|IS1634-family-transposase	gnl\|CDD\|227708	COG5421, COG5421, Transposase [DNA replication, recombination, and repair].	1.53607e-08

>NC_022663.1|WP_036444322.1|1759007_1762328_+|LuxR-family-transcriptional-regulator
MSEFLPTRTVTLLLADVQGSAQLWQTQREAMASAVGRLDRTASEMVTAHGGVGPVEPGSDGSDGSDGSDGSDGFEGSDGFDGFVAVFPRATDALACAVDLQQAPLAPIQLRVAVHTGEVTQRKPGNYGGPALSRAARLRDLAHGGQIVLSGTTHDLVIDELPANVWLKDLGTHRLRGLARPERVAQLCHPDLRIEFPPLHAPDSIALHGFPAHLTRFVGRAAQINDVCKFLADHRLVTLAGAGGVGKTRLAVQIATAASAEVGSGAWFVDLAPVSDPDVVPVAVLRALSIADQPGRSAMDSLVRFVGDRDLLVVLDNCEHLTDACAALAGELLGACPRLTILTTSRAPIGVPGELTWRVPSLSLADEAIELFVDRARLARPEFGVTAADVDMVGEICARLDGLPLGIELAAAAVRVMSLSEILDGLRHRFRLLTDGTPTASQRRKTLGTSVDWSHTLLTEPERVLFRRLAVFNGGFDLEAARAVCADDDLHQHQVLDLLTRLVDKSLVVAEPAGDRTRFRMLETVRHYALAKLRDYGPDAGEADAMRARHRDHYARLAALLDSPGEKRDQRQIEQVEIEIDNLRAAFAWSRETGETDRALELTSSLQPLWLTRGRIQEGLAWFDAVLTDHDMSAVAAVVRGRALADKAALDASRSVHDNLDQAQQAVAIARKLNDRALLARGLTACGAISSYSADAARPYLAEALDIARELGDRWRLTQILTWQAYGAFYAGDPVAARASSQEGLDLAEAIGDQFHARSCRWTLGLAQLMEGDVPDAIAQFRAVTADADAAHDVLFRWGSRLALSQALAFRGDTGAARVAATASLAAAADLWPYNEGFSYAVLATAAVAAGDVAAAAEASEAARQRLSVQGQLAGANTNPMAEVALARGDLITAGRWADQEVAASAGWHLARALTTRARIAIAKGDPDQAERDAHKALVCAAEHQANLAVPDILECLGRLAPDGRSHRDAARFFGAAHEIRRRFGAARFAVYDADYERTVAITRDALGQQAFDTAWAEGTGLTIDQAIAYVRRGRGERKRPASGWASLTPTERDVVRLVADGLANNEIAARLFISRRTVQTHLTHVYAKLGINSRVQLAHEGASRG
>NC_022663.1|WP_036392713.1|1756914_1758681_-|PPE-family-protein
MNFVILPPEINSARVYLGAGSGPMLAAAAAWDGLAGELGSAAGSFGSVTSGLTGAVWQGPAATAMVEAAAPYVGWLSAAAAHAQGAAGQARTAVSAFEAAVAATVHPVAVAANRNQLVSLVVSNLFGQNAPAIAAAETAYEQMWAQDVAAMVGYHGEAAAVVAQLAPMQSGLQQALQTLPGMLANLGVGNAGSGNLGGGNHGDNNLGSGNNGSHNVGSGNAGNTNLGNGNSGNSNVGNGNRGDQNFGSGNSGGTNTGNGNIGTGNVGSGNLGNGNLGNGNLGNSNVGSGNRGDNNMGFGNRGSSNIGVSNTGNHDFGFGNTGNNDIGFGLTGDNQVGFGALNSGSGNIGFGNSGSGNVGFFNSGTGNVGLFNSGGHSFGAENSGSFNTGLTNSGQGNTGFVNAGFNSLGLANAGANNMGVFNGGSQNFGFGNSGFQNTGSWNAGSINTGDFNAGSINTGWANSGASNTGGFDSGSLNTGFGSMLTPVGAKNSGFGTTGLDSSGFFNSGGDTSGFQNTGLAFESGFHNSGNGNNAGINNTGSFLAGIGNTGFDNIGIANSNVFNSGIGNSGNDDSGFFNKTDAQSGFFN
>NC_022663.1|WP_023366804.1|1754295_1755861_-|PE-family-protein
MSFVIAAPELVQGAAHDLAGLRSSLAEAAAIAAGPTTGIAAAAQDEVSIAIASMFGNFGQEFQVLSAQAQAFHDRFVSLLNTGAGAYLSAEAANVEQTLLGGGAGGVTQLLGNVGQEVAGQIQTGAQAISQAIGGLQTGLGALATGGLPGLPDGLASFGATVAGPYQTLFATTGANLQSLQSALAANPQPLLHQILSNQTGYQQTVATALQSAIQNFPADLATVPADIRNLLSGDPAAVLQTIINQHMGYAQTINTALHSAAQDFRTGAAGLHSAFQAAFQDLATGNVDGAVGDISTGLRDLFLTGFAPTVDLDTGIITITPTGTLGDLIPTLAIPGQMAQNFTNLLPAGSIPAQISQNLTNVIQTATSTTQTLDLGTGALHVGLPLVLALDAIGPAVTTANAFGSSASAVIGAMQTGDMLGAVTALIDAPAVVANGFLNGHATLPLALSVLGLDTTTNIPLGGILTPAETASLTLTVFGETGTLPLSGTAFGGIVPALLTFLPEQLAEAIGAPLPGPPTM
>NC_022663.1|WP_042313446.1|1752781_1754128_+|FAD-dependent-oxidoreductase
MADVDFCVVGAGFAGLTAALRLHRAGASVVLLEARDRAGGRTYTVTRDDGVWIDRGGAWIGPGQDRIYALMAEFGVPEYKQYNDGEAMMIVGGKKHRYGGTIPWTLSPWAVTNLGLGLAAVEKMCKSIPREAPWEAKRADEWDRISLGQWLDKNTLSKPARDMLDMALAGPYTSAASETSLLWVLLQMASGGGPTFVISGKGGAQDARPVGGMGAIYGPMVTELGEAVHFSQPVRLIAQDGDGVTIRSDHLTVRARRAIVAIPLAIANSIDYEPVLPVDRALLHHRMPSGAVYKISIVYDEPFWRADGLSGQSAAPGSPATLTIDACTDTAVPGIMCVITEGPAARRLARLDEAERKAVVIGELADRFGATARAPREFHEQDWILERYSGGGMISHAPTGVLTQFGYTLRPPCGRIHWAGTESSATMCGWVDGAIRSGERAASEVLAA
>NC_022663.1|WP_080674035.1|1752061_1752658_+|SHOCT-domain-containing-protein
MLVDPEIGAAGLGFDSIVGITGLPYDIVGYQIGVHTDDIVSEWAGIESFPGTAPVPSASITDLGGSAVSAGLGEANSIAGLSVPPTWTAAAPEIRSLAVALPATSLGAAEVSAGGAGSLFSQMALAGMAGRAMAGAGNGSLRERVGAVKRDPLSAAASSATGPITGIAAELRELAALRDSGILTEDEFTEQKQRLLPH
>NC_022663.1|WP_036392442.1|1750151_1751864_-|IS1634-family-transposase
MDKAGQRRDYQSVYLRRSFRDGGTVKHQQLANLSALPEAAISAIEAVLSGATMVAAGDAVRIESSLPHGHVAAVHTMARTLGLPALLGPPCRARDLAYGLIVSRVLRPGSKLSTLTGWADTTLGADLGITGASSDEVYAAMDWLHQRQDHIEKQLAARHLDHEVNPSRIAMFDLSSSWVTGRCCELAARGYSRDGKKGCPQIEYGLLTDPAGRPVAIRVFAGNTADPTAFRAAVTTVKDRFGLTNMVMVGDRGMITSARITALKDLGGIGWLTALRAPSIAALAADDGPLQMSLFDDHDFAEITHPDYPGERLICCRNPLLAAERARKRGELLNATEQLLAPITAAVAARRLVGADQIGLKIGKVIDKYKMAKHLHVTITDTTVTITRRHTQISAEAALDGIYVLRTSVPASDLASAAVINAYKNLANVERDFRSLKTDDLDLRPIHHRLEDRVRAHVLICMLAAYLTWHLRHALAPLTFTDENPPTRDNPVAPAQRSPQAATKAARKTTTDAQLPTHSYQGLLTHLATLTRNQVRFAGTKTPVPMLTEATDTQTRAFQLLNTTIPLSLQ
>NC_022663.1|WP_023366792.1|1749351_1750092_+|PPE-family-protein
MDFAVLPPEINSARIYAGPGSGPMLAAATAWDGLAAELHSVASSYESVIGGLACGPWVGPSSASMAAAAAEFVTWTRATAAGAEQAAGQAAAAAAAYETAFAQTVPPPVVAANRTLLTALIVTNLFGQNTPAIAVAEAQYADMWVQDAAAMYGYAGSSASATRLTPFTPPPPNTEPGGLSVQAAAVARATGASAGNARHNASSTSRSVSAVPNTLSSLASPAAAIPSLTPLEWLDLLADLSPKLRR
>NC_022663.1|WP_080674034.1|1748082_1748673_-|twin-arginine-translocation-signal-domain-containing-protein
MSRRQFLAKLAAATGAAAFMSVAGPAIDKAYPAGPCSGHLSDIEHFVLLMQENRSFDSYFGTLSGVNGFDGASPAFQQKGGNPATQAKDPSGITVPYRFDTTRGPLLDDECVNDPVRRIATPGCDRRSWSGCTTSSGRWRPGWSRAARYRNHPETAPGPQRCRRPRPRSARTASRWSMRHTAICSRGHGIRGRSGR
>NC_022663.1|WP_023366786.1|1746288_1748025_-|DUF3556-domain-containing-protein
MGFLKPELPQVDVAEWSKGTRSEKIRPMARHWAEVGFGTPVALHLFYVVKIGLYILGAWLVVLSTKGIDGFTNVRSWYSEPIVFEKVVLYTMLFEVIGLGCGFGPLNNRFFPPLGSILYWLRPNTIRLPPWPGRVALTRGTARAPIDVLLYAALLVMTLWALFSDGTGPVPELGTKVGLLPVWQIWTILAILAVAGLRDKVIFLAARGEVYASLTVTFLFGGADLIVAAKLVFLVIWMGAATSKLNKHFPFVISTMMSNNPLIRPRFIKRRFFEKFPDDLRPGRLSRIIAHVSTFIEMAVPVVLFFAHGGWPTAVAAFVMVCFHLGILTAIPMGVPLEWNVFMIFGVLSLFVGHAELGLTDVKNPVPVGILFAVVAGTVVLGNVFPRKISFLPGMRYYAGNWDTTLWCIKPSASEKIGKGIVAIASMPAAQLERFYGKDKAQIPMYLGYAFRAMNTHGRALFTLAHRAMAGQNEDDYVITDGERICSTAIGWNFGDGHMHNEQLIAAMQERCHFEPGEVRIVLLDAQPIHKQTQAYRLVDAATGEFERGYVRVADMVTRQPWADDVPVHLLSDEFRRV
>NC_022663.1|WP_036392726.1|1743731_1746011_+|5-methyltetrahydropteroyltriglutamate---homocysteine-S-methyltransferase
MTAHSSQKFTATITGSPRIGPRRELKRATEGYWAGRTSRSELESVAATLRRGTWTDLAAAGLDSVPINTFSYYDQMLDTAVLLGALPARVSGISDGLDRYFAAARGNADVAPLEMTKWFDTNYHYLVPEIGPSTTFTLNPDKVLAELKEAQELGIPARPLIIGPVTFLLLSKAVDGAAPPIERLQELVPIYAELLSLLAGEGARWVQLDEPALVTDICPDAPALAERMYTALGSLSNRPAIHVATYFGDPGAALPALARTPVEAIGVDLVAGARTAVAGVPELAGKTLVAGVVDGRNVWRTDLEAALGRLATLLGSAATVAVSTSCSTMHVPYSLEPETELDDNLRSWLAFGAEKVREVVVLARALRDGRDAVAEEIAASNAAVASRRRDPRLRNGQVRARIDSIVASGAHRGDAAARRASQDARLHLPALPTTTIGSYPQTAAIRKARAAFRSGEIDEAEYVRRMKTEIADVISLQEQLGLDVLVHGEPERNDMVQYFAEQLQGFFATQNGWVQSYGSRCVRPPILYGDVARPHPMTVDWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLAETANQVALAIRDETVDLQAAGIAVIQVDEPALRELLPLRRGEQDEYLRWAVTAFRLATSGVADSTQIHTHLCYSEFGEIIGAIADLDADVTSIEAARSHMEVLDDLNAAGFANSVGPGVYDIHSPRVPSSQEMAESLRAALKAVPVQRLWVNPDCGLKTRNVDEVTGSLRNMVAAAREVRADV
>NC_022663.1|WP_036392710.1|1765303_1766839_-|radical-SAM-protein
MDLRGDSIHRYVNAFCPRCHDEEPDRPLSSVARLSGWLAVRDGLVWLERGCRSHGLVRTLYDEDPEILAYLEEWTAPTKAHIPDTPGNFDPIPSAYLRGLPQMQTQHTCILLEDIAETCNLRCPTCFADSSPDLRHVVAIGDVLANVDQRLERENGRLDVLMLSGGEPSLHPQLPELLAELSARPITRILLNTNGIRVAQDDGLLDVLTEHRERAEVYLQYDGLSQAAHRYHRGGDLRRIKQDALRRLSEREIFTTLVMTAALGVNDHEIGDVVRLALRTPYAGGVCIQPQFGSGRSGFIDADNRLTHTGVLRRLGPQTDDLVTWRDLTALPCSHPHCCSVGYLLRDDGGRWRSLVALIGHDNLKDKLGLVANRIADRDIPRELRLAVRESLLALLSEQSSLSHPQMSDVWRLICQNCDLGMATLLTLASSALPGRRRQLRRLLGERVLRITVKPFMDMSTMIEERLVQCCVHVGTRSSQDQCAPFCAVQAWPALGRQRLSVAAERLLPVV
>NC_022663.1|WP_051404574.1|1766844_1767075_-|hypothetical-protein
MVIAGLAQAVSSHAALVTGAIVLGLIAFGGGGVLVALRNPWARGIGMGLMIGWAVASIVTVGFCTGLNPTLYGTAG
>NC_022663.1|WP_036392707.1|1767236_1768022_-|prolipoprotein-diacylglyceryl-transferase
MVPHWWVGPLTLPVHGMFVGLGVLVATAVFFAEARRRGAVNDQSLVAVTGALVGGAIGMRLSGWAEHIDVRLNPTLLQAWEFGSRSILGGLAGAYVGVLIAKRIGGFRGKTGDLFAPAVALGMAVGRIGCHLTEAPGRPTGLPWGVHAPAATPKCPGCLIGAAMHPSFLYEIGFQLAAFAVLLWLRNKLTQPGELFVLYVAGYAVFRFFVEFVRANETVWLGLTRPQWFLLPSVVLIAVRLGYGYQRGHYDPLLHRQALPA
>NC_022663.1|WP_036445312.1|1768124_1768739_+|hypothetical-protein
MQDIWQPWGANAAPGTGADGGAGGILIGNGGAGGSGAPGMPGGNGGPAGLFGIGGTGGFGANIAGSGGAGGNAGILGGNGGAGGAAGISQSGIGAPGGAGGNAGVLYGNGGVGGTGGTSRFGGLGGNGGVGGKAGLIGNGGDGGAGGNSGSATGTGGNGGAGGSAWLIGDGGNGGNGGIGVTPGTGGAGGTGGQLLGQDGNNGQ
>NC_022663.1|WP_023366823.1|1768779_1769289_-|DoxX-family-protein
MTPYDVGLLILRLVLGLTLAAHGLNKFFGGGRIPGTARWFESIGMKPGRFHATVAASTETAAGLGLAAGLLTPIPAAGFVSLMLVAAWTVHRPNGFFIVKEGWEYNLVLAVSAVVVATLGAGRLSLDWMIFGKNWFDGWGGLLISLGLGLAGAIGQLLIFYRPPVQRTG
>NC_022663.1|WP_160937993.1|1769433_1771059_+|pyruvate,-phosphate-dikinase
MARIPRGRDPLEDPPKRIWKDPVVLLDGQAEHSREVLGNKGHGIDVMRRHALPVPPAFCITTEVGVRYLADPDPTMDAIWDVVIERMGWLEAETSRTFGRGPRPLLVSVRSGATQSMPGMMDTILDLGVNDAVEQALARACTAEFARDTRRRFNRMYRRVTGQHPAEDPYEQLRVGIGAVFTSWNSPRAKAYREHYGRDDQGGTAVVVQAMVFGNQTARSGAGVLSSRNPITGANEPFGDWLPGGQGDDVVSGLVDVEPIATLRDELPAVYDELIEAARRLEQLTSDVPEIEFTVENGKLWLLQTRSAERSAQAAVRLALQLRHDGLIDDAQTLRRVTPAAVEAVLRPALQPETRLAAPLLAKGLPACPGVATGIAYTDVDAALDAAERGEPVILVRDHTRPEDVLGMLAAQGIVTEVGGAASHAAVVSRELGRVAVVGCGHGVAATLAGKQITVDGHEGEVRDGSLSLSAWSENDTPELRELTGIALRLSPLRAHATGDYPRLEDHSEAAVRAAMTAGHRDVVSDTPLIAMLHALRASAD
>NC_022663.1|WP_023366831.1|1771970_1772780_+|hypothetical-protein
MKFPYATILLSLLALSVTTEVLWMGNISRPPTAIYHIWHVALMLFVITVRLAYQQRLSPQVARYTRILIAGMAMCAVGDVVNSAISGIEPISQKLSTAIILFGAGYTLYVYVLYRFSQPRLAQRGGTGYRMRWFVLMIIAVANTVGWISYVREPVAGHQFLELGSFLFNLVIYTLMISFSIWYFWANRLSLPALPVLIGGLLLPLSDLYLFSTWLAPGQDRNVPTFDLYAANWILYFGGQVLFAFLPACENDAMLSESPQPGNRHAELG
>NC_022663.1|WP_036445318.1|1772851_1773454_+|hypothetical-protein
MHVKVLQAVRLKGRVSPTDLATTLGEDLRAITEIVDQLTASGLLLEGATLRISPSGRTRLNALLAEERTRVDPAAMAAAYNEFRSVNADFKVVVTDWQLKGGQPNVHDDAGYDDAVLARLDNVHRRVEPIIAAAATQLPRLHAYSAKLNAALDKVKSGDIAWLTRPLIDSYHTVWFELHEELILAVGLTREEAARSGDAQ
>NC_022663.1|WP_160937641.1|1773457_1774687_-|DUF1298-domain-containing-protein
MAAVDAQFYWMSAKIPNDQFLLYAFDGEAVAVERAVAQLLDRAHACPQLRMRVHARSALTYPQWVAAGVEPEQVVRHEPTDDSWHGCLAAVTGLADEQLDIRRMPWRVHVFTPVTGIPGVRGAGTVAVVQVAHALGDGARASAMAAWLFGRAAPVAPVTGPRRGVLPWRAAAAAYAHRRLVRDTRSGRLAPSAGSRPLLSTNARPEGVRAVRTLVRQRSQLPGPTVTIAVLAAVSTALSRLLGGSAESLAAEVPMAKPGVPQAHNHFGNVVVGLYPALGHAERVGRIAADVANARRRMRHPAVRAADLAFATIPAVLLRWGVSQFDADARPAQVAGNTVVSSVHRGAADLHFGDAPVVLTAGYPALSPAMGLTHGVHGIGDTIAISVHAAASAIPDIDAYAQLLDAALQ
>NC_022663.1|WP_023366837.1|1774706_1775612_-|alpha/beta-hydrolase
MPEPHWIDVPGAGADLKALTWGPAGAPIALCLHGFPDTPYGWRKVAPRLAKAGWRVVAPFMRGYAPSSIPADGCYHVGALMHDALRVRAAAGGTDDDVVIGHDWGAIAATGLAAMPDSPFARAVIMSVPPAAAFRPLGRVPDRGRLARELPHQLLRSWYIAYFQLPWLPERSAAWLPTLLWRRWSPGYYAEEDLRHVDAAIGTPESWRAALGPYRATIRNTRPPAAYAELNRWWTEPPRLPSLYLHGRDDGCATPAFTHWTENVLPAGSDVAIVDHAGHFLQLEQPEKVAELILTFVGTPG

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Crispr_ID: NC_022663_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022663_8

1947289-1947613

Orphan

Consensus_repeat	Method
GCCGGCGGTCTGCCGGCGCTGCCGG	CRISPRCasFinder

6 spacers

The CRISPR arrays of NC_022663_8

>merge|NC_022663|8|1947289-1947613|CRISPRCasFinder
GCCGCCGGACTGCCCGGTCTGCCCGGAGTGTCGCCCACCGATGTGGTGGCCCTGGCGGCCGGTGGCTTGCCACAGCTGGCGTCCGCTCTGCCCGGGCTGCAGGCCGGTCTGCCGGCGCTGCCGGGCGTGGATCCAGCGATGCTGGCCGCGGCGTTGCCGGCGCTGGCGGCAGGTCTACCGGGCGGCCTTCCGGCGGTTGACCCGGCGATGCTGGCCGCGGCACTGCCCGCACTGACCGCCGGCGGTCTGCCGGCGCTGCCGGGTGGGCTGCCGGCGTTGCCGGGCGGGCTGCCGGCGCTGCCGGGCGGTCTGCCGGCGCTGCCGG

>NC_022663|8|7|1947289-1947613|CRISPRCasFinder
GCCGCCGGACTGCCCGGTCTGCCCG	GAGTGTCGCCCACCGATGTGGTGGCCCTGGCG
GCCGGTGGCTTGCCACAGCTGGCGT	CCGCTCTGCCCGGGCTG
CAGGCCGGTCTGCCGGCGCTGCCGG	GCGTGGATCCAGCGATGCTG
GCCGCGGCGTTGCCGGCGCTGGCGG	CAGGTCTACCGGGCGGCCTTCCGGCGGTTGACCCGGCGATGCTG
GCCGCGGCACTGCCCGCACTGACCG	CCGGCGGTCTGCCGGCGCTG
CCGGGTGGGCTGCCGGCGTTGCCGG	GCGGGCTGCCGGCGCTG
CCGGGCGGTCTGCCGGCGCTGCCGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_022663.1\|WP_036393827.1\|1953191_1953845_-\|DUF5642-family-protein	unknown	unknown	gnl\|CDD\|376126
NC_022663.1\|WP_036393534.1\|1933323_1934193_-\|TatD-family-hydrolase	unknown	unknown	gnl\|CDD\|272852
NC_022663.1\|WP_178131773.1\|1952585_1953182_+\|alpha-ketoglutarate-dependent-dioxygenase-AlkB	unknown	unknown	gnl\|CDD\|225687
NC_022663.1\|WP_036393816.1\|1934234_1935788_+\|methionine--tRNA-ligase	unknown	unknown	gnl\|CDD\|237012
NC_022663.1\|WP_036393542.1\|1940547_1942413_-\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|236645
NC_022663.1\|WP_023367131.1\|1947761_1948619_-\|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase	unknown	unknown	gnl\|CDD\|223390
NC_022663.1\|WP_023367127.1\|1944088_1944994_+\|RNA-polymerase-sigma-70-factor	unknown	unknown	gnl\|CDD\|132002
NC_022663.1\|WP_042312028.1\|1936597_1936963_+\|PAS-sensor-domain-containing-protein	unknown	unknown	gnl\|CDD\|379177
NC_022663.1\|WP_178131774.1\|1956760_1958320_+\|phospholipase-C	unknown	unknown	gnl\|CDD\|226042
NC_022663.1\|WP_023367137.1\|1951300_1952506_-\|arginine-deiminase	unknown	unknown	gnl\|CDD\|234949
NC_022663.1\|WP_023367117.1\|1937019_1937685_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_022663.1\|WP_023367129.1\|1945042_1946326_+\|aminodeoxychorismate-synthase-component-I	unknown	unknown	gnl\|CDD\|235634
NC_022663.1\|WP_023367145.1\|1954562_1955564_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|237999
NC_022663.1\|WP_023367133.1\|1948643_1950200_+\|dolichyl-phosphate-mannose--protein-mannosyltransferase	unknown	unknown	gnl\|CDD\|224839
NC_022663.1\|WP_023367125.1\|1942857_1944057_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224172
NC_022663.1\|WP_023367135.1\|1950331_1950640_-\|DUF732-domain-containing-protein	unknown	unknown	gnl\|CDD\|368380
NC_022663.1\|WP_036393541.1\|1938827_1940534_-\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_023367143.1\|1953872_1954550_-\|DUF5642-family-protein	unknown	unknown	gnl\|CDD\|376126
NC_022663.1\|WP_023367147.1\|1955702_1956449_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|181382
NC_022663.1\|WP_023367119.1\|1937797_1938493_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228

Protein	Function_ID	Function_description	E-value
NC_022663.1\|WP_036393827.1\|1953191_1953845_-\|DUF5642-family-protein	gnl\|CDD\|376126	pfam18702, DUF5642, Domain of unknown function (DUF5642). This is a domain of unknown function found in actinobacteria.	2.08689e-74
NC_022663.1\|WP_023367133.1\|1948643_1950200_+\|dolichyl-phosphate-mannose--protein-mannosyltransferase	gnl\|CDD\|224839	COG1928, PMT1, Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones].	6.02573e-68
NC_022663.1\|WP_178131773.1\|1952585_1953182_+\|alpha-ketoglutarate-dependent-dioxygenase-AlkB	gnl\|CDD\|225687	COG3145, AlkB, Alkylated DNA repair protein [DNA replication, recombination, and repair].	2.46625e-44
NC_022663.1\|WP_036393816.1\|1934234_1935788_+\|methionine--tRNA-ligase	gnl\|CDD\|237012	PRK11893, PRK11893, methionyl-tRNA synthetase; Reviewed.	0
NC_022663.1\|WP_036393542.1\|1940547_1942413_-\|EAL-domain-containing-protein	gnl\|CDD\|236645	PRK10060, PRK10060, cyclic di-GMP phosphodiesterase.	3.47013e-97
NC_022663.1\|WP_023367131.1\|1947761_1948619_-\|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase	gnl\|CDD\|223390	COG0313, COG0313, Predicted methyltransferases [General function prediction only].	2.98205e-115
NC_022663.1\|WP_023367127.1\|1944088_1944994_+\|RNA-polymerase-sigma-70-factor	gnl\|CDD\|132002	TIGR02957, putative_sigma_factor, RNA polymerase sigma-70 factor, TIGR02957 family. This group of sigma factors are members of the sigma-70 family (TIGR02937). They and appear by homology, tree building and bidirectional best hits, to represent a conserved family. This family is found in a limited number of bacterial lineages. This family includes apparent paralogous expansion in Streptomyces coelicolor A3(2), and multiple copies in Mycobacterium smegmatis MC2, Streptomyces avermitilis MA-4680 and Nocardia farcinica IFM10152.	1.46274e-110
NC_022663.1\|WP_036393534.1\|1933323_1934193_-\|TatD-family-hydrolase	gnl\|CDD\|272852	TIGR00010, Uncharacterized_deoxyribonuclease_MG009, hydrolase, TatD family. PSI-BLAST, starting with a urease alpha subunit, finds a large superfamily of proteins, including a number of different enzymes that act as hydrolases at C-N bonds other than peptide bonds (EC 3.5.-.-), many uncharacterized proteins, and the members of this family. Several genomes have multiple paralogs related to this family. However, a set of 17 proteins can be found, one each from 17 of the first 20 genomes, such that each member forms a bidirectional best hit across genomes with all other members of the set. This core set (and one other near-perfect member), but not the other paralogs, form the seed for this model. Additionally, members of the seed alignment and all trusted hits, but not all paralogs, have a conserved motif DxHxH near the amino end. The member from E. coli was recently shown to have DNase activity. [Unknown function, Enzymes of unknown specificity].	1.82178e-112
NC_022663.1\|WP_042312028.1\|1936597_1936963_+\|PAS-sensor-domain-containing-protein	gnl\|CDD\|379177	pfam13426, PAS_9, PAS domain.	1.66476e-12
NC_022663.1\|WP_178131774.1\|1956760_1958320_+\|phospholipase-C	gnl\|CDD\|226042	COG3511, PlcC, Phospholipase C [Cell envelope biogenesis, outer membrane].	0
NC_022663.1\|WP_023367137.1\|1951300_1952506_-\|arginine-deiminase	gnl\|CDD\|234949	PRK01388, PRK01388, arginine deiminase; Provisional.	0
NC_022663.1\|WP_023367117.1\|1937019_1937685_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.12342e-12
NC_022663.1\|WP_023367129.1\|1945042_1946326_+\|aminodeoxychorismate-synthase-component-I	gnl\|CDD\|235634	PRK05877, PRK05877, aminodeoxychorismate synthase component I; Provisional.	0
NC_022663.1\|WP_023367145.1\|1954562_1955564_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|237999	cd00038, CAP_ED, effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels.	3.86941e-19
NC_022663.1\|WP_023367125.1\|1942857_1944057_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|224172	COG1252, Ndh, NADH dehydrogenase, FAD-containing subunit [Energy production and conversion].	4.43074e-68
NC_022663.1\|WP_023367135.1\|1950331_1950640_-\|DUF732-domain-containing-protein	gnl\|CDD\|368380	pfam05305, DUF732, Protein of unknown function (DUF732). This family consists of several uncharacterized Mycobacterium tuberculosis and leprae proteins of unknown function.	1.53341e-21
NC_022663.1\|WP_023367143.1\|1953872_1954550_-\|DUF5642-family-protein	gnl\|CDD\|376126	pfam18702, DUF5642, Domain of unknown function (DUF5642). This is a domain of unknown function found in actinobacteria.	2.69273e-71
NC_022663.1\|WP_023367147.1\|1955702_1956449_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|181382	PRK08317, PRK08317, hypothetical protein; Provisional.	1.24975e-25
NC_022663.1\|WP_023367119.1\|1937797_1938493_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.88474e-11

>NC_022663.1|WP_023367129.1|1945042_1946326_+|aminodeoxychorismate-synthase-component-I
MRIDRLGDLGGAPQVLRAVARATVRLGLAPPAALTGEWFGALAVIAPSVSVRPVDRGDAFPVREAPGEPVAPVSGAVGGGWVGYLSYPDPGADGRGSRIPEAAGGWTDCVLRRDRDGHWWYESLSDAPMPDWLVSALATTPAPAGRPVPGTCRIDWAAADREAHRGGVLACLAAITAGEVYQACVCTQFTGTVSGSALDFFIDFVDAAGTSPSRAAYVGGPWGAVASLSPELFLRRHGTGVASSPIKGTLPLEAWPSALRASPKEVAENIMIVDLVRNDLGRVAITGTVTVPELLVVRRAPGVWHLVSTVAAQVPADLPMSALLDAAFPPASVTGTPKLRARQLISQWEQHRRGIYCGTVGFASPIAGSELNVAIRTVEFDAAGNAVLGVGGGITADSDPDAEWQECLHKAAPIVGMAVPATATRVG
>NC_022663.1|WP_023367127.1|1944088_1944994_+|RNA-polymerase-sigma-70-factor
MTQSPGEHAQRFTLLRPMLFTIAYEILGSATESEDVLQDSYVRWAGVDLETVRDTKSYLAQLVTRQALNALRAGARRREEYVGPWLPEPLLLDEQDPAADVVLAESVSMAMLVLLETLSPDERAVFVLREVFGFDYAEIADAVGKSGPAVRQIAHRAREHVQARRKRYGARPVDPQRHAQITAQFLETATSGDVEALMAMLAPDAAWMADSGGKVSAARRPVVGAERVARAITGLMRKAGALLRVEIATCNSAPAVLFYLGEHLEGVITLEIVDDKITNFYVMRNPEKLTALASPREISRG
>NC_022663.1|WP_023367125.1|1942857_1944057_+|FAD-dependent-oxidoreductase
MFEPTPLTGPRTHVVVVGGGYAGTVAANHLRLNADIDITVVNSRPVFVERIRLHQLAAGSGTATVEYGTLLGEGIELIVDTVDRIDSADRRLRLASGAQLEYDYLIYAVGSTGATPAVPGAAEFAYSLADLDGATRLRHILMDLPAAAPVVVVGGGLTGIEAASELAEQGRPVTLVCGGPLGPSLSKRGRRSVARQLRRLGVAVLESVAVSQVRWDAVVLSDHTVLTSAVTVWTAGFEVPDLAARSGLRTDALGRLLTDETLTSADDERIVAAGDCAAPSGQPLRMSCQAAGPLGAQAANTVLSRIAGETPAMLSQAFVGQCISLGRSHGTVQLSRSDDTPVNVAVGGRTGAAIKEAICKGTVWSIRHEAAKPGSYFWFKGGKRAAQLPAEQQAAVKSR
>NC_022663.1|WP_036393542.1|1940547_1942413_-|EAL-domain-containing-protein
MPRSLDLVVTSVATQLMEATASTATQVSQRVLAQLVEQFDVDASFLRHHDHEIRASVLVAEWPPRRDVADPDPEGVVHFTSADPVLTQCEHGRKPVVIRPHRNNRFFRRWLGGSIAAASPSVAAAPLVSGQATTGVLGFVKFGARKWRHEEINTLEAVAALFAQLQARIAAEEKLRYLAEHDDLTGLHNRRALLAHLSERLAAGTPGPVAVLYLDLDRLKSINDYLGHNAGDWFIRLFAQRLRGCVGGQSMIARLGGDEFVVIPDQAMSKGAAESFARRLSSMLRERLAIGGHQITRTVSIGLAVGMPGRDDGTDLLRRADEAVLTAKRAGGNQVALATDDMSLKSAFRNDIELHLQGDIDSDALVLHYLPEVDLWTGAVVAAEALVRWRHPIWGLLLPDSFIGVAESTNLAGELGRCVMRSACAEFSRWRKNGVGQSAVLRINVSPVQLITRGFVRSVADTIEEFGIDGGSVCLEITERAVVHDIEATRKTLSELKDVGVQVAIDDFGTGYAVLSHLKSLPVDMLKIDTGFVRDLGTNAGDLAIVRAIIGLAEAFGLQVVAEGVETPAAALTLMQHGCHRAQGFLLSRPVPGNAMEALLSARWMPMPFLADREALTLGAI
>NC_022663.1|WP_036393541.1|1938827_1940534_-|hypothetical-protein
MVRAIRKSSIVAACAVLLPGGALTGCSSHQPDNSPLTAMVSPAIPSTVQEIPNPLRGQYEDLLEPLFPQRDPAQQRYPAWPASYDASLRVSWRQLQPTDPATLPPDAPDERKYDFSVIDDALSRLAERRMRMTLRVYAYNSCCNASYPNNTNIAIPDWERARPGTNTTYPGPANGAAAGVLQVVPNFNDPTYLNDFVQLLAALGRRYDGDERLSVFEFSGYGDFSENHIAYLRDSLNAAGPAPEDSVAALGYYSQFRDQNITKASIQRLVEANVSAFPRTQLVTSAANPEIIRELLADDVTKKLAAPVGMRSDCLGVYAPMPAWADGSAAHYVQTNDPVVAALRKRLSTALVITEWCQLPSGTTRQAYYEKGLRDIMRYHVSMTSSINFPDDDATSPMDPKLYVLWAQANATAGYRYSVEAKPGSQGLSKDGKVATISVVWTNYGSAAATEKWVPGYRLVDFTGQTVRTLPASVNLKSLVPEAPGDRTAQQPIPASASETVRVELADLPAGHYTLRASVDWQQHKPNGAHVVNYPPMQLARDGRDDSGFYPVATLDIPRDVQTATNGA
>NC_022663.1|WP_023367119.1|1937797_1938493_-|TetR/AcrR-family-transcriptional-regulator
MNSSAQTTTDSTSGRADTTRQQILQAAAHQFARRAYHDVGLDDILAAAQLTKGAMYFHFRSKHALAVAIIEQHTAAGRGVVEELLARQLSGLETLVDFVYLIAVRDISQDMDRAASNLLGSVGRTEGLQTKLLDGWIEALASVVRRAIVEGDVAEGCDPQDVGRLIVSIYMGLRQASDLDAPERFLRDLEKSWLLVLRGIAQPDRVDYFTQFIARRTVLAIRSATALVAPD
>NC_022663.1|WP_023367117.1|1937019_1937685_-|TetR/AcrR-family-transcriptional-regulator
MARQVRSEITRRKILDAAVDVFGEAGYAAAGWGTIIDRTGMTKGALYHHFDSKEALASAIIEEGSEALLGAFRNVCGSASPALENMIHGTFAVAHLLSVDKVARAAEQLTAVLAGFNAAAAHFFSAGVGEMAEQARRAIAEGDLRDDVDPELVSESIVGATFGMRLQANALSGPGANGYGVESPAERLGQLWGLLLPGMTVETSLPYFREFLAREAMRSRQ
>NC_022663.1|WP_042312028.1|1936597_1936963_+|PAS-sensor-domain-containing-protein
MIALQQLPALVVLERIPVPVLATGDDGSILFTNTAFAQMVGRDPDEVLSLRFHEIFHQCPDSASSTLSFVHALANMVVELAHKDGSVVRALMSRSAVRRADDNFALAVFQDLTEQLWEEER
>NC_022663.1|WP_036393816.1|1934234_1935788_+|methionine--tRNA-ligase
MQPYYVTTAIAYPNAAPHVGHAYEYIATDAIARFKRLDGFDVRFLTGTDEHGLKVAQAAAAAGVPTAQLARRNSDVFQRMQEALNISFDRFIRTTDPDHYAASQEIWRRMEAAGDLYLDNYSGWYSVRDERFFVESETQLVDGTRIAIETGTPVTWTEEQTYFFRLSAYADKLLAHYHAHPDFIAPEVRRNEVISFVSGGLKDLSVSRTSFNWGVPVPEHPDHVMYVWVDALTNYLTGAGYPDTGSESFRRYWPADLHMIGKDIIRFHAVYWPAFLMSAGIELPRKVFAHGFLHNRGEKMSKSVGNVIDPVALIQAYGVDQVRYFLLREVPFGQDGSYSDEAIVTRINTDLANELGNLAQRSLSMVAKNLGGVVPEPGEFCDADTELLATADGLLDRVRAHFDRQAMHLALEAIWLMLGDANKYFSTQQPWVLRKSESEADQARFRTTLYTTCEVVRIAALLVQPVMPESAAKMLDLLGQPDDRRAFSAVGTRLAPGTQLPPPTGVFPRYQPPSEVE
>NC_022663.1|WP_036393534.1|1933323_1934193_-|TatD-family-hydrolase
MRVSTNRPATPQAPPAPEPLAPLIDAHTHLDACGARDARDVAEVVDRAEAVGVRAVVTVADDLESARWVTRATEWDPRVYAAVALHPTRADALTDAARAEITELVAHPRVVAVGETGMDLYWPGRLDGCAQPVVQREAFAWHIDLAKRTGKPLMIHNRQADREVLDVLRAEGAPDTVIFHCFSSGSAMARECVAAGWLLSLSGTVTFRNARDLREAVPLIPLEHVLVETDAPFLTPHPYRGTANEPYCLPYTVRALAELVDRRPEEVAQITTSNAARAYELGHTAGGWP
>NC_022663.1|WP_023367131.1|1947761_1948619_-|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase
MSSGRLLLGATPLGQPADASPRLIDALAGADVVAAEDTRRVKTLARALDVEISGRVVSLFDRVEALRVTALVDAMQAGATVLVVSDAGLPVINDPGYRLVAACIDAGITVTCLPGPSAVTTALVVSGLPSDKFCFEGFAPRKGAARRAWLASLADEQRTCVFFESPRRLAACLRDAVEQLGGARPAAVCRELTKVHEEVVRGSLDELADWATGGVLGEITVVLAGAGATPTADLQSLVEEVEHLVAAGIRVKDACSEVAAAHQGVRSRQLYDAVLLARRETDAAP
>NC_022663.1|WP_023367133.1|1948643_1950200_+|dolichyl-phosphate-mannose--protein-mannosyltransferase
MTAPPQQTSGLAEERAAPVISPGPLVPIADFGPVDRMRGWIVTAVITLLAAVTRFLNLGSPTDAGTPIFDEKHYAPQAWQVLHNHGVEDNPGFGLVVHPPVGKQMIAIGEALFGYTGFGWRFSGAVLGVILVALVTRIVRRITRSTLVGGIAGVLLICDGVSFVAARTALLDGFLTFFVVAAFGALIVDRDQVRQRMHVALSENRVAETVWGPRLGVRWWRFGAGVLLGLAFATKWSGLYFIAFFGAMSLAFDVAARRQYQVPRPWLGTLRRDLLPTGYALALIPFAVYLASYAGWFASETAIDRHQVGQTIGPDSVLPLPDAVRSLWYYTAKAFHFHATLTNSAGNHHPWESKPWSWPMSLRPVLYAIDQQNVSGCGGQSCVKAEMLVGTPAMWWLAVPVLLYAAWRMFVRRDWRYAVVLVGYCAGWLPWFADIDRQMYFFYAATMAPFLVMAIALILGDVLYQPGQGRERRTLGLIVVSCYVALVVTNFAWLFPILTGLPISQQTWNMEIWLPSWR
>NC_022663.1|WP_023367135.1|1950331_1950640_-|DUF732-domain-containing-protein
MGLLLSAFTTIGIAAPALADAGVDLGARDVGFLGALQDAGITYSNPGHAVESAHAMCRNLHHGESGLQAVQQVKIQNPPIDLDTASRFAVIAAKYYCPEQLY
>NC_022663.1|WP_023367137.1|1951300_1952506_-|arginine-deiminase
MGVELGSNSEVGTLRVAILHRPGTELRRLTPRNSDQLLFDGLPWVSRAQEEHDEFAELLRSRGVTVLLLSELLTEALASGAARMQGVAAAVDARRLGLPLAQQLSAYLRSLDPVRLAHVLTAGMTFNELPSDIRTDVSLVVRMHQGGDFVIEPLPNLVFTRDSSIWIGPRVVIPSLALRARVREASLTDIIYAHHPRFTGVRRAYESRTAPVEGGDVLLLAPGVVAVGVGERTTPAGAEALARSLFDDDLAHTVLAVPIAQKRAQMHLDTVCTMVDVDTVVMYAAVVDTLSAFTIRRCPNGATISDAAPFVQAAADAMGIEKLRVIGTGLDPVVAEREQWDDGNNTLALAPGVVVAYERNAQTNARLEAAGIEVLTIAGSELGTGRGGPRCMSCPAARDPL
>NC_022663.1|WP_178131773.1|1952585_1953182_+|alpha-ketoglutarate-dependent-dioxygenase-AlkB
MAFAVQGSLFEHNERRQLGNGAFIDIRAGWLHGGDDLLAALLAGVPWRSERRQMYDRVVDVPRLVSFHDLTVEDPPHPQLTRIRRRLNDIYGGELGEPFTTVGLCYYRDGSDSVAWHGDTIGRSSTEDTMVAIVSLGATRVFALRPRGGGTSLRFPLAHGDLLVMGGSCQRTWEHAVPKTTAPTGPRVSIQFRPRDVR
>NC_022663.1|WP_036393827.1|1953191_1953845_-|DUF5642-family-protein
MSKVVLALVAVCLLVGCSPGASQSPKADIAKVIDVKASFGPGFTVNDVPPRAIDPQFFAARKLPDGLSFDPANCAKAALGPQMPSGVQGNMAAVTAEGNGNRFVVIAVETSQQLPFNDPGKECGRIAFSGAQVRGGIEMVAAPHIDGAQTLGVHRVLQALVDGSARTGELYDYSAQFGYYQVNVIANPLVIPNQPVAPVDVQRARDLLVKAVAAIRG
>NC_022663.1|WP_023367143.1|1953872_1954550_-|DUF5642-family-protein
MRPLWIGVMATALAAACAQSPAPVTAPTHTSPSAHPTTVNPANIKRISRELPPGYEVTRDIPAGASPRLVFGLGANATAQPAPCATLADPGHGRDQSAQGVSGSGEGGIVGAVVVAVRPRPVAPGSDVVAGCAQWTMSDGHTSAAIRLIDPPHIDGAPTLAMVADVRTSVESGTEIDSRTYTFIAYLGDYYAFTTLTTDPGSMLPPLPPRFAADLLVKTVSTLRG
>NC_022663.1|WP_023367145.1|1954562_1955564_-|GNAT-family-N-acetyltransferase
MDGMAELTGARTAELAGMDIFAGCPADDLLPLAARLAPLRAAAGQVLMRQGEQAVSFLLISSGSAEVIHVGDDGAVIVEQALPGMIVGEIALLRDIPRTATVTTVEPLTGWIGGTDALDRMVNIPGIMDRLVRTVRQRLAAFITPVPVRIRDGTQLLLRPVLPGDSERTVHGHIHFSSETIYRRFMSARVPDAAMMHYLSEVDYVDHFVWVMIDGIDPVADARFIRDEHDPTVAEIAFTVADAYQGRGIGSFLIGALSVAARVGGVERFSARMLSDNVPMRTIMDRHGAIWQREDIGVITTVIDVPGPRALDFGREMAEQIRRVARQVIEAVS
>NC_022663.1|WP_023367147.1|1955702_1956449_+|class-I-SAM-dependent-methyltransferase
MNTSPDPRESTRGLLNTAAVLRHGFLDVLGESTSSPVPTLAQRAMNSRFVATVYERLWRPTSFYLASGITARAEQRRAAAALRLSTAHRLLDVACGPGNFTAPLARCLPAGALAVGFDISEPMLTRAVVDNDGPQTCYVRGDARVLPFDDETFDAVCCFGALYLMPEPFDITREMLRVLRPGGRIAILTSYAGQAAPIRKALTATANLIGLTMFDRSSFVDLFSSAGLVDIEQQTQRALQFVAATKPR
>NC_022663.1|WP_178131774.1|1956760_1958320_+|phospholipase-C
MSKHPVDGMSRREFMARIATAGSAGALMSLAGPVIERAYGAGPCSGHLTDIEHFVLMLQENRSFDHFFGTLSGINGFDTPSPSFQQKGWNPQTQSIDPAGVTIPYRFDTTRGPVLNGACVNDPAHQWITIHKSWNNGANDNWLPAQAEQQTLQGNVPVSMGYYTRQDQPIHYLLADTFTICDGYYCSLLGGTSPNRLYWISAWIDPDGVAGGPLLIDPNIQPQAQFSWRTMPDNLSDAGISWKVYQNKLLGALNNTVIGYNGMLVDFKQAQDPRSNIARNGIAPTYPLDFVADVAANRLPQVSWVLPGFQVSEHPGLPVTPAVGGTAIVNILRILLSNPQVWEKTALIVSFDENGGFFDHVTPPTAPPGTPGEYVTVPDIDAVTGSGGIRGPIGLGYRVPCFIISPYSRGPLMVHDTFDHTSQLRLLEKRFGVPVPNLSAWRRSVTGDMTSTFNFAVPPNPAPPNLDHPALQAIPPQVQCVPDTVATFAKVTPPYRVPFPQVMPTQETTPARGIPSGPC

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Crispr_ID: NC_022663_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022663_9

3394583-3394678

Orphan

Consensus_repeat	Method
TGCCGTATCGAGCGTGCTTGCCGTATCGAGCGTGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022663_9

>merge|NC_022663|9|3394583-3394678|CRISPRCasFinder
TGCCGTATCGAGCGTGCTTGCCGTATCGAGCGTGCTTGCCGTATCGAGCGTGCGGTGGTGCTGCTGTATCGAGCGTGCTTGCCGTATCGAGCGTGC

>NC_022663|9|8|3394583-3394678|CRISPRCasFinder
TGCCGTATCGAGCGTGCTTGCCGTATCGAGCGTGC	TTGCCGTATCGAGCGTGCGGTGGTGC
TGCTGTATCGAGCGTGCTTGCCGTATCGAGCGTGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_022663.1\|WP_023369327.1\|3402033_3402666_-\|RES-family-NAD+-phosphorylase	unknown	unknown	gnl\|CDD\|378053
NC_022663.1\|WP_036394877.1\|3402662_3403250_-\|DUF2384-domain-containing-protein	unknown	unknown	unknown
NC_022663.1\|WP_023369300.1\|3388706_3389369_-\|peroxiredoxin	unknown	unknown	gnl\|CDD\|239314
NC_022663.1\|WP_080674086.1\|3389471_3390233_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NC_022663.1\|WP_023369308.1\|3392283_3394260_+\|cytochrome-c-oxidase-assembly-protein	unknown	unknown	gnl\|CDD\|225873
NC_022663.1\|WP_036394872.1\|3387131_3387530_-\|iron-sulfur-cluster-assembly-scaffold-protein	unknown	unknown	gnl\|CDD\|143480
NC_022663.1\|WP_023369318.1\|3398298_3398454_+\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_023369309.1\|3395091_3396243_-\|PPE-family-protein	unknown	unknown	gnl\|CDD\|366325
NC_022663.1\|WP_023369320.1\|3399021_3400320_+\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_023369313.1\|3396801_3397830_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|366154
NC_022663.1\|WP_051404582.1\|3405937_3407068_-\|PPE-family-protein	unknown	unknown	gnl\|CDD\|227938
NC_022663.1\|WP_023369297.1\|3387532_3388678_-\|acyl-protein-synthetase	unknown	unknown	gnl\|CDD\|282319
NC_022663.1\|WP_133163560.1\|3398501_3398891_+\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_023369306.1\|3391482_3392121_-\|DUF5134-domain-containing-protein	unknown	unknown	gnl\|CDD\|375044
NC_022663.1\|WP_023369333.1\|3404790_3405882_+\|cation-transporter	unknown	unknown	gnl\|CDD\|223131
NC_022663.1\|WP_023369289.1\|3384497_3384812_-\|acyl-carrier-protein	unknown	unknown	gnl\|CDD\|376348
NC_022663.1\|WP_080674085.1\|3385930_3387154_-\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|224029
NC_022663.1\|WP_023369316.1\|3397972_3398302_+\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_023369304.1\|3390251_3391358_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226957
NC_022663.1\|WP_023369291.1\|3384827_3385934_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|378928

Protein	Function_ID	Function_description	E-value
NC_022663.1\|WP_023369327.1\|3402033_3402666_-\|RES-family-NAD+-phosphorylase	gnl\|CDD\|378053	pfam08808, RES, RES domain. This presumed domain contains 3 highly conserved polar groups that could form an active site. These are an arginine, glutamate and serine, hence the RES domain. The domain is found widely distributed in bacteria. The domain is about 150 residues in length.	1.45221e-08
NC_022663.1\|WP_023369300.1\|3388706_3389369_-\|peroxiredoxin	gnl\|CDD\|239314	cd03016, PRX_1cys, Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by reducing and detoxifying hydrogen peroxide, peroxynitrite, and organic hydroperoxides. As with all other PRXs, a cysteine sulfenic acid intermediate is formed upon reaction of 1-cys PRX with its substrates. Having no resolving cysteine, the oxidized enzyme is resolved by an external small-molecule or protein reductant such as thioredoxin or glutaredoxin. Similar to typical 2-cys PRX, 1-cys PRX forms a functional dimeric unit with a B-type interface, as well as a decameric structure which is stabilized in the reduced form of the enzyme. Other oligomeric forms, tetramers and hexamers, have also been reported. Mammalian 1-cys PRX is localized cellularly in the cytosol and is expressed at high levels in brain, eye, testes and lung. The seed-specific plant 1-cys PRXs protect tissues from reactive oxygen species during desiccation and are also called rehydrins.	2.66805e-108
NC_022663.1\|WP_080674086.1\|3389471_3390233_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	2.232e-100
NC_022663.1\|WP_023369308.1\|3392283_3394260_+\|cytochrome-c-oxidase-assembly-protein	gnl\|CDD\|225873	COG3336, COG3336, Predicted membrane protein [Function unknown].	5.32145e-103
NC_022663.1\|WP_036394872.1\|3387131_3387530_-\|iron-sulfur-cluster-assembly-scaffold-protein	gnl\|CDD\|143480	cd06664, IscU_like, Iron-sulfur cluster scaffold-like proteins. IscU_like and NifU_like proteins. IscU and NifU function as a scaffold for the assembly of [2Fe-2S] clusters before they are transferred to apo target proteins. They are highly conserved and play vital roles in the ISC and NIF systems of Fe-S protein maturation. NIF genes participate in nitrogen fixation in several isolated bacterial species. The NifU domain, however, is also found in bacteria that do not fix nitrogen, so it may have wider significance in the cell. Human IscU interacts with frataxin, the Friedreich ataxia gene product, and incorrectly spliced IscU has been shown to disrupt iron homeostasis in skeletal muscle and cause myopathy.	5.07107e-32
NC_022663.1\|WP_023369309.1\|3395091_3396243_-\|PPE-family-protein	gnl\|CDD\|366325	pfam00823, PPE, PPE family. This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	4.09274e-53
NC_022663.1\|WP_023369313.1\|3396801_3397830_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	2.91065e-29
NC_022663.1\|WP_051404582.1\|3405937_3407068_-\|PPE-family-protein	gnl\|CDD\|227938	COG5651, COG5651, PPE-repeat proteins [Cell motility and secretion].	3.75626e-47
NC_022663.1\|WP_023369297.1\|3387532_3388678_-\|acyl-protein-synthetase	gnl\|CDD\|282319	pfam04443, LuxE, Acyl-protein synthetase, LuxE. LuxE is an acyl-protein synthetase found in bioluminescent bacteria. LuxE catalyzes the formation of an acyl-protein thioester from a fatty acid and a protein. This is the second step in the bioluminescent fatty acid reduction system, which converts tetradecanoic acid to the aldehyde substrate of the luciferase-catalyzed bioluminescence reaction A conserved cysteine found at position 364 in Photobacterium phosphoreum LuxE is thought to be acylated during the transfer of the acyl group from the synthetase subunit to the reductase. The carboxyl terminal of the synthetase is though to act as a flexible arm to transfer acyl groups between the sites of activation and reduction. This family also includes Vibrio cholerae RBFN protein, which is involved in the biosynthesis of the O-antigen component 3-deoxy-L-glycero-tetronic acid.	1.18725e-38
NC_022663.1\|WP_023369306.1\|3391482_3392121_-\|DUF5134-domain-containing-protein	gnl\|CDD\|375044	pfam17197, DUF5134, Domain of unknown function (DUF5134). Proteins in this family are uncharacterized, but have been identified as members of a gene cluster for the synthesis of the tetramic-acid antibiotic streptolydigin, which inhibits bacterial RNA polymerase (RNAP).	4.65526e-25
NC_022663.1\|WP_023369333.1\|3404790_3405882_+\|cation-transporter	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	1.60794e-80
NC_022663.1\|WP_023369289.1\|3384497_3384812_-\|acyl-carrier-protein	gnl\|CDD\|376348	pfam00550, PP-binding, Phosphopantetheine attachment site. A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of the anguibactin system regulator AngR has the attachment serine replaced by an alanine.	2.58038e-05
NC_022663.1\|WP_080674085.1\|3385930_3387154_-\|cysteine-desulfurase	gnl\|CDD\|224029	COG1104, NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism].	5.87349e-134
NC_022663.1\|WP_023369304.1\|3390251_3391358_-\|ABC-transporter-permease	gnl\|CDD\|226957	COG4591, LolE, ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane].	1.18283e-12
NC_022663.1\|WP_023369291.1\|3384827_3385934_-\|ABC-transporter-permease	gnl\|CDD\|378928	pfam12704, MacB_PCD, MacB-like periplasmic core domain. This family represents the periplasmic core domain found in a variety of ABC transporters. The structure of this family has been solved for the MacB protein. Some structural similarity was found to the periplasmic domain of the AcrB multidrug efflux transporter.	2.18003e-12

>NC_022663.1|WP_023369308.1|3392283_3394260_+|cytochrome-c-oxidase-assembly-protein
MQTDVTADRSPSAVPASRSISWALAGLLLGLLGISGVLAGYGLASGARRYATAGNPYPGGFLCIAEPLGYFLASLATAVCLGALVYVVIASRPEHDGLIDAAAFRVHLVAERVSVAWLGLAVVMVVIQAAHDAGVAPSQLLGGGALLDAVGASEVARGWIVAAIGALVVAVTLRLITRWVGHFVLLIPTVIAVVATAVTGNAGQGPDHDYTTSAAIVFTLALATLTGLKTATAVATATPGRAVQVMQVACGALTLSYGAVLLYLLIPGWSFDSDFARLGLAAGLVVALVWLSDCWGLFVRPAGSGGARIAGALTMMAVMAAVAAMAIQTAPRYVTHQFSAWDVFLGYELPQPPNVVTLVTEWRFDSLVGTLGVVLAVGYVVAYVRLRKNGNAWPVGRLMAWLTGCVVLVFTSSSGLRAYGSAMFSVHMAEHMTLNMFVPVLLVLGGPVTLALRVLPAAGDGQPPGPREWLTWLLHSRVTAFLSHPITAFILFVASPYIVYFTPLFDILVRYHWGHEFMAVHFLIVGYLFYWAIIGIDPGPRRLPYPGRIGLLFAVMPFHAFFGIALMTTSSAIGSGFYQSVGLPWLPSIVADQHLGGGIAWGATELPIIIVIVALVAQWARQDRRVAAREDRHADSNYADDDLDAYNAMLRELSRMRR
>NC_022663.1|WP_023369306.1|3391482_3392121_-|DUF5134-domain-containing-protein
MVDELLLRWLVTGLFVLSGANYVVAAIGQRGRWVYLVSNGLHLVMAIAMVVMIWPWGIHAPTTGPAAFFLLAAGWFIALTVVSAKTIAQWTAGSYHALMMLAMTWMYVVMNGHLLPGNPVTPHPASTAVSMPGMEMSAMPMPPESSQPGWVASVNWLWFLVFTIAAIVWTAVSLAGWRRGATECKRDILAQTGRISMALAMAIVFAALLSGG
>NC_022663.1|WP_023369304.1|3390251_3391358_-|ABC-transporter-permease
MIVAVKNLVAERARLVFSVLGVGIAVLLVLVISGIFVGTTNRVTTYIDHYKGAVWVVQPGVSQMFKAVSWLPGDGRERLLTVPGVQSADPLLGSPSDFVHNGTHTAYFVLGYDTRTGVGGPWSLAQGRNVARSGEVVLDRVLATKNGIRLGDKVRIVDENFTVVGLSNQTAAVTNYYAFISLPDAARLLRAGNRVSYFLVRPRDGYTAEQVAAAIHRDMAGMDALTAASFAEKSRDIVVSMIGRPLKTMIAIAVLVGVALVGLTVLAVTNEQLRDFGVLRALGVRPIQLCRTVLAQAALIAGLGYLAGAAVAYGAQFLIADRLGDVTVEITPTMLATMAAATAVMAVLGSLIPVRRVVRIDPVTAFRH
>NC_022663.1|WP_080674086.1|3389471_3390233_-|ABC-transporter-ATP-binding-protein
MRCPVCHHDASAPRCAQCRRPIPEDTSGPVLRLTDITVDYGGGATAVHALQGVDLSVERGEVVLVVGPSGGGKTTALLVMGLLLTPDGGTVQICGHDAGRLSERRRAELRLARLGYLFQDYNLLQSLTSVENVALPLRYAGVRKPAAIARARQLLHELDLGHRAHHRPAALSGGEKQRVAAARALAMGPDVILADEPTANLDSATGKKVSAQLASAAKAQDSAVVIVTHDARLEDIADRVLHLEDGRLLAATA
>NC_022663.1|WP_023369300.1|3388706_3389369_-|peroxiredoxin
MTLTIGSTAPDFEATTTDGPIKFHEWIGDSWAVLFSHPRDFTPVCTTELGYLATIKPEFDRRNVKIIGLSTDPLDSHAAWSKDIACTSGTAPNYPLIADTDYAVSKAYGMLPATIGGDPSDHPPAELATLRNVFVIDPNKTIMLVMIYPMTTGRNFDEVLRAIDSLQLLNNGLATPAQWRQGDDVIIAPWISDEQARHTYPDGWQGPLPYLRYVPSPQGL
>NC_022663.1|WP_023369297.1|3387532_3388678_-|acyl-protein-synthetase
MDLVTMLGMPGDALRAPAYEARTSLTNALRKAFEHHFQHNGFYRAQCDAAGVTPADIHDYGDLHRIPLLPVGMFKQTGAHVLLTSGLEDIEMEIRSTGTSGVPSVARRDTLTVTRASVGLLGCYRDFFGISHGAGLFLCPSTAEIPEMGMVKVFNLLTGLLDDHSYLVRDYSFHPDEALARLRHWEGRMTRHIVGPPFIVARFMRYLELEAISLTLDPESLIIMLGGWKQYTGRSISRAEFNDKAERLLGIHRTRIRDMYGMIESNMLAIECEHQRKHVPPWCYVSIRDIADPTTELGTGQTGGIAILDALNTAYPGFLLSDDVGEVDEGTCRCGRTGQTVHFRRRRHGAELGCCAVSIEKYLDSREVVTECELAQTSRRA
>NC_022663.1|WP_036394872.1|3387131_3387530_-|iron-sulfur-cluster-assembly-scaffold-protein
MSRYSPTVVDHFNNPRNCGRLANPDVSAFVGNPVCGDQILLTVRVEADAVSEVAFEAYGCSASLAVGSILTERLGGMTISDIAALDAARILQWSGGLGPDQHHVAVLGADAAHRLADNYRKGIHDDGTCFAG
>NC_022663.1|WP_080674085.1|3385930_3387154_-|cysteine-desulfurase
MAPVSPVDGRAAVSVSPIHPGTDGVDGLYLDYAATAPLHPAAARAVHAGQQLLGNPSSGHAAGRAAADALRDARRSIARLLGVTPREVVLTSGGSEANALALWGTFAAHGFTGHLVTTSIEHSAVLENARALEKLDVAVTIVDPGPGGHVEAAAVAAAMRPDTVLVSVMHANNETGAIQPVHEIAALAAHAGVAFHMDAVHTAGKLSLDAVGASLISVSAHKFGGPRGVGALAVRNGHPLVPMVRGGPQENRLRAGTENVAGAMGMAAAVEVCLRRRSMGHRLGIRERREQLILGLAGTGGVHVNSTEPVLEETISVRFDGVRADTLADSLDMQGIYVSTGSACHAGHDAVSHVLTAMGLTERAARSTVRFSLGPEVTPDDIDRVVSVTTQAVQRLRGIAGTTGARQ
>NC_022663.1|WP_023369291.1|3384827_3385934_-|ABC-transporter-permease
MIIAVKNLVVERARLMFSVLGVGIAVLLVLVISGIFVGTTNQVTTYIDHSKGAVWVVQPGVEQLFRAVSWLPADGRGRLLTVPGVQSADPILGQPSDFVHNGTQTAYFVVGYDTRTGAGGPWSLAQGRNVARSGEVVLDRVLASKNGIKLGDKVQIVDEDFTVVGLSNQTAALGNFYAFISLPDAARLLRAGNRVSYFLVQPRDGYTATQLAAAIHRDLPDMDALAAATFTDNSRAIIISMIGRPLKTMIAIAVLVGVALVGLTVLAVTNEQLRDFGVLRALGVRPIQLCRTVLAQAALIAGLGYLAGAAVAYGAQFLIADRLGDVTVEITPTMLATMAAATAVMAVLGSLIPVRRVVRIDPVTAFRH
>NC_022663.1|WP_023369289.1|3384497_3384812_-|acyl-carrier-protein
MTENRSALILPEAGEVIGAFRDALEKVLAPEDLAQVDLVRVDSETPLLSLPIDSAVLMSLMTELEDRFAVFIDEEAAFAFETVADITDYVRRRLTDKAGRLAGA
>NC_022663.1|WP_023369309.1|3395091_3396243_-|PPE-family-protein
MMDFGALPPEINSARMYAGPGAGSLLAAAAAWECLAADLYSLAAAYQSVISGLSVGSWLGPASMLMAAAAAPYVAWMNATAAQAEQAGIQAMAAVTAFNAVFSMTVPPPVIAENRAMLMTLVATDILGQNAAAIAATEAEYAEMWARDAAAMYGYAAASAAASTLTPFEEAPETTHADGLARQLALVGEVEAAAIRQLMSEVPRALRMLSEPAPWQWLVELWRGISPHLGTFRDIVSIGQNCVSVTNNTLAMTQMGAAMSRAVPAAVSEAAGAAAKAIAGGTTALGSASGGLGGSGLAAGLGRAASVGSLSVPQSWAAANHAINPAVRALPGTSLGSAAQSAPGHMLGGLPLGPTPSGGGSGVNGALRIPPRAYVMPRIPAAG
>NC_022663.1|WP_023369313.1|3396801_3397830_+|glycosyltransferase-family-2-protein
MLLSGDNRRGLEEVFDHPRERHVSNPNALAGIRCTADAFASGRLGATLRSSAAIAMSQQLSVAIVIPAHNEERFIGKCLDACLSQTSAPDEIIVVNNKSSDNTVSIVRRYQEENPHIDIRLLNQNEHLGIAPTRNCGFDHARSQIIGRIDADSVVDTDWVETIRQCFQDSAIDAVTGPVHYYDIPLRGPIFRIDRMVRRNLHRTATDQRFLLGANMAIRTSAWQAVRHLTQLDLEDRLHEDIDLALTLFKNNFEIAYESTMVVGASGRRVECSPLDFFRYATRYTRTTKAHGVKSRSARITIAVLMLGYVPVRTLRFFYDAENNRFTRKRSGTGGGTKSTDY
>NC_022663.1|WP_023369316.1|3397972_3398302_+|hypothetical-protein
MPANESSGLGMPVNWGIGTPDLPIPQLTGMPTLPNPFPAMPSLADLFCRPNGVPKLPATAELAALPDFSGTLAGLPTMAQLTAPLSQLTQLSGAAGGLNQPVNTASRHR
>NC_022663.1|WP_023369318.1|3398298_3398454_+|hypothetical-protein
MIASQTEQRATRADHVTEDDDTLGAAVGTTSAPRAPVDAANGEIILHNTPF
>NC_022663.1|WP_133163560.1|3398501_3398891_+|hypothetical-protein
METSSEIRILDFDAGTSKFSDSTGTPRRKILFMSQPCTLTVNQSDILARAGEVEFSIVGPPSGAVVYGLLIDLRVTTSQNASNLHGPTQKLTDFPRAPADAATATGSSHQRTTAGAANALTSPTEPVQR
>NC_022663.1|WP_023369320.1|3399021_3400320_+|hypothetical-protein
MTGPVGWVEDPEFVKLLDALTEENVGTLFSNQGPPELVPELAPEPGPELPPEPDTSDISDNNPEQRLLRGSVVCFGTFSALAGMLGWLGHASPDPGDRLVASGSMFDDVSAHIAALGPDGGWQGSAAQAYLAQILAQSQRAKLMRDLDRRTRGLVSTQAQAVADTRAWLIHEMIIVAAVGISCLALEESGLPGGQQVSLAVAVVVCTAALGVAIYKLVWLKHTTSQNAHNLQGLTQRLTAIATTSPTLPDAIPGLPDVPAAPSPITGPPDDTGPLPKTPDISLALADLTGSPEFSVSDLPRPGFPDFGAPGLAIPEVAGLPHPATASELAALPDFSGALAAVPTMAQLTAALGQLTGLSGAAGGLSQLTTMAGQQAQMISALAQQGTQQHASLADQVTKDDDNAGAAAGATTAEHAPVDDASRSLQRRQRVL
>NC_022663.1|WP_023369327.1|3402033_3402666_-|RES-family-NAD+-phosphorylase
MSPRSKPKVPRTPPEKLTRQPDDSTSYTGTLWRIHRTEGEHVLPWNKLRTFGPLPSMRWDPHPDAEPSMRAEGVLYAAADVATGLAEVYQTTRVIDTRAGAPTLTAWKPQRKLRLLDLSGTWLLRNSASAALLAAPRSICRRWARAIYTTWPELDGLYVPSTMTGRPNIVLWTAAADSLPALPSFSRPLSHPLVWSITQAAASEIGYRIL
>NC_022663.1|WP_036394877.1|3402662_3403250_-|DUF2384-domain-containing-protein
MKGSAAPALGALLAKHQIGLTVDEVLNELDSAFAAIPAAATLSAAEVDFLRKHAEPSMATAIDRWSADDERQARARVALRQLTSAVSGSVSIKEAAVLLGVDRSRVSRRITGKQLWAFDLQGTRRLPKWQFLGNELLPGLDLIVPAIPPGSTPAVLDVFMHTPQPDFDGRTPIEHLAAGGDASLVAGFIRDLGRW
>NC_022663.1|WP_023369333.1|3404790_3405882_+|cation-transporter
MSDHHSETFSAAATYGGHNPSADDHGNHHHPKGWRAVVREIFAPHSHDAADSIDNALESSAAGIRAVKISLLVLGITAIAQIAVVTISGSIALAADTIHNFSDALTAVPLWIAFALSTKAATRRYTYGFGRVEDLAGLFVVAMITMSAIIAGYEAVVRLIHPQPVENVGWVALAGLIGFIGNEWVALYRIGVGRRIGSAALVADGLHARTDGFTSLAVLVAAGAVALGVPLADPIIGLVITVAILAVLRTAVRDVFHRLLDSVDPALIDTAEAVLATRPGVRSVRSLRMRWIGHRLHADAELDIDATLSLADAHRIAHDAEHGLIHAVPKLTTALIHAYPADHPNAAEQHRHGSEPPTEMSSF
>NC_022663.1|WP_051404582.1|3405937_3407068_-|PPE-family-protein
MDFAALPPEINSGRMYAGGGSGSLRAAAAAWEVLAADLYATAVEYLAVVSVLTEGPWRGSVSASMAAAAAPYVSWLATTASQAQHAAGQARAAAQAYEVAFQMTVPPAEVAANRTMLSWLVATNALGQNITAIATTESQYAEMWAQDAAAMYAYASASAAASQVAPFADPPPTTSEAGLTAQAAAVARAAESDAHLTTLSQLLSRVPLALQELASPMLSMDPPDWLDFIFVTAVPLILSSVSSCLGLTQSLASLSLVAGSAAQVAAGDAASLGSALAGGLGSAAGMSSAGAALSASLGGAGSIGGLSVPASWAALPAAGSAAAPLPTSWGVMPESTAGVPGMPGVPIAGTAGQGMGGAVPRYGFRPMVVPRPPAAG

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Crispr_ID: NC_022663_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022663_10

3773639-3773746

Orphan

Consensus_repeat	Method
CCCTTTGGAGGCGGCGGCCACGGTGGTGGT	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NC_022663_10

>merge|NC_022663|10|3773639-3773746|CRISPRCasFinder
CCCGTCGGGGGCGGCGGCCCCTTTGGAGGCGGCGGCCACGGTGGTGGTGGCCACGGCGGCTTCGGCGGTGGGCACGGACCCTTGGGAGGCGGCGGCCACGGTGGTGGT

>NC_022663|10|9|3773639-3773746|CRISPRCasFinder
CCCGTCGGGGGCGGCGGCCCCTTTGGAGGC	GGCGGCCACGGTGGTGGTGGCCACGGCGGCTTCGGCGGTGGGCACGGA
CCCTTGGGAGGCGGCGGCCACGGTGGTGGT

Protein	Signature genes	Signature genes Name	Protein_function
NC_022663.1\|WP_023369960.1\|3764902_3765853_-\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|271178
NC_022663.1\|WP_023369982.1\|3776968_3777646_+\|metalloregulator-ArsR/SmtB-family-transcription-factor	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238089
NC_022663.1\|WP_023369964.1\|3767302_3767518_+\|transposase	unknown	unknown	gnl\|CDD\|372671
NC_022663.1\|WP_023369980.1\|3775481_3776831_+\|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|223936
NC_022663.1\|WP_023369995.1\|3782925_3783300_+\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|378915
NC_022663.1\|WP_023369984.1\|3777669_3778449_-\|membrane-protein	unknown	unknown	gnl\|CDD\|224931
NC_022663.1\|WP_023369970.1\|3769953_3770622_+\|pyroglutamyl-peptidase-I	unknown	unknown	gnl\|CDD\|171894
NC_022663.1\|WP_036444000.1\|3770739_3771396_+\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_023369974.1\|3771484_3772057_+\|dCTP-deaminase	unknown	unknown	gnl\|CDD\|234753
NC_022663.1\|WP_023369962.1\|3765849_3767049_-\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|271188
NC_022663.1\|WP_023369985.1\|3778681_3779350_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NC_022663.1\|WP_099184505.1\|3769158_3769911_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223505
NC_022663.1\|WP_036396178.1\|3767567_3768623_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_022663.1\|WP_142396053.1\|3763439_3763649_-\|transposase	unknown	unknown	gnl\|CDD\|372671
NC_022663.1\|WP_036396187.1\|3782158_3782914_+\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	unknown	unknown	gnl\|CDD\|274422
NC_022663.1\|WP_023369991.1\|3781824_3782070_+\|DUF4190-domain-containing-protein	unknown	unknown	gnl\|CDD\|379388
NC_022663.1\|WP_036396171.1\|3773983_3775405_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237030
NC_022663.1\|WP_023369987.1\|3779622_3780804_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223523
NC_022663.1\|WP_023369958.1\|3763862_3764903_-\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271183
NC_022663.1\|WP_023369989.1\|3780800_3781604_+\|nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|350158

Protein	Function_ID	Function_description	E-value
NC_022663.1\|WP_023369960.1\|3764902_3765853_-\|tyrosine-type-recombinase/integrase	gnl\|CDD\|271178	cd00797, INT_RitB_C_like, C-terminal catalytic domain of recombinase RitB, a component of the recombinase trio. Recombinases belonging to the RitA (also known as pAE1 due to its presence in the deletion prone region of plasmid pAE1 of Alcaligenes eutrophus H1), RitB, and RitC families are associated in a complex referred to as a Recombinase in Trio (RIT) element. These RIT elements consist of three adjacent and unidirectional overlapping genes, one from each family (ritABC in order of transcription). All three integrases contain a catalytic motif, suggesting that they are all active enzymes. However, their specific roles are not yet fully understood. All three families belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism.	5.76037e-43
NC_022663.1\|WP_023369982.1\|3776968_3777646_+\|metalloregulator-ArsR/SmtB-family-transcription-factor	gnl\|CDD\|238089	cd00158, RHOD, Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and certain stress proteins such as senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions (no active site cysteine) are also seen in dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases, where they are believed to play a regulatory role in multidomain proteins.	1.16602e-21
NC_022663.1\|WP_023369964.1\|3767302_3767518_+\|transposase	gnl\|CDD\|372671	pfam13683, rve_3, Integrase core domain.	1.60856e-12
NC_022663.1\|WP_023369980.1\|3775481_3776831_+\|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	gnl\|CDD\|223936	COG1004, Ugd, Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane].	0
NC_022663.1\|WP_023369995.1\|3782925_3783300_+\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|378915	pfam12680, SnoaL_2, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	0.000116581
NC_022663.1\|WP_023369984.1\|3777669_3778449_-\|membrane-protein	gnl\|CDD\|224931	COG2020, STE14, Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones].	2.02585e-09
NC_022663.1\|WP_023369970.1\|3769953_3770622_+\|pyroglutamyl-peptidase-I	gnl\|CDD\|171894	PRK13195, PRK13195, pyrrolidone-carboxylate peptidase; Provisional.	5.70605e-125
NC_022663.1\|WP_023369974.1\|3771484_3772057_+\|dCTP-deaminase	gnl\|CDD\|234753	PRK00416, dcd, deoxycytidine triphosphate deaminase; Reviewed.	1.01865e-98
NC_022663.1\|WP_023369962.1\|3765849_3767049_-\|tyrosine-type-recombinase/integrase	gnl\|CDD\|271188	cd01188, INT_RitA_C_like, C-terminal catalytic domain of recombinase RitA, a component of the recombinase trio. Recombinases RitA (also known as pAE1), RitB, and RitC are encoded by three adjacent and overlapping genes. Collectively they are known as the Recombinase in Trio (RIT). This RitA family includes various bacterial integrases and integrases from the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus H1. All three integrases contain a catalytic motif, suggesting that they are all active enzymes. However, their specific roles are not fully understood. All three families belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	1.21568e-53
NC_022663.1\|WP_023369985.1\|3778681_3779350_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	3.68589e-20
NC_022663.1\|WP_099184505.1\|3769158_3769911_-\|hypothetical-protein	gnl\|CDD\|223505	COG0428, COG0428, Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism].	1.12551e-24
NC_022663.1\|WP_036396178.1\|3767567_3768623_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	6.44934e-56
NC_022663.1\|WP_142396053.1\|3763439_3763649_-\|transposase	gnl\|CDD\|372671	pfam13683, rve_3, Integrase core domain.	7.16682e-10
NC_022663.1\|WP_036396187.1\|3782158_3782914_+\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	gnl\|CDD\|274422	TIGR03083, TIGR03083, uncharacterized Actinobacterial protein TIGR03083. This protein family pulls together several groups of proteins, each very different from the others. They share in common three conserved regions. The first is a region of about 38 amino acids, nearly always at the N-terminus of a protein. This region has a bulky hydrophobic residue, usually Trp, at position 29, and a His residue at position 37 that is invariant, so far, in over 150 instances. The second conserved region has a motif [DE]xxxHxxD. The third conserved region contains a hydrophobic patch and a well-conserved Arg residue. Most examples are found in the Actinobacteria, including the genera Mycobacterium, Corynebacterium, Streptomyces, Nocardia, Frankia, etc. The pattern of near-invariant residues against a backdrop of extreme sequence divergence suggests enzymatic activity and conservation of active site residues.	3.83381e-19
NC_022663.1\|WP_023369991.1\|3781824_3782070_+\|DUF4190-domain-containing-protein	gnl\|CDD\|379388	pfam13828, DUF4190, Domain of unknown function (DUF4190). This integral membrane domain is functionally uncharacterized. One of the membrane helices contains two GXXG motifs that are usually associated with dimerization.	0.00187864
NC_022663.1\|WP_036396171.1\|3773983_3775405_+\|hypothetical-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	8.79293e-15
NC_022663.1\|WP_023369987.1\|3779622_3780804_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|223523	COG0446, HcaD, Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only].	2.22293e-34
NC_022663.1\|WP_023369958.1\|3763862_3764903_-\|site-specific-integrase	gnl\|CDD\|271183	cd01182, INT_RitC_C_like, C-terminal catalytic domain of recombinase RitC, a component of the recombinase trio. Recombinases belonging to the RitA (also known as pAE1 due to its presence in the deletion prone region of plasmid pAE1 of Alcaligenes eutrophus H1), RitB, and RitC families are associated in a complex referred to as a Recombinase in Trio (RIT) element. These RIT elements consist of three adjacent and unidirectional overlapping genes, one from each family (ritABC in order of transcription). All three integrases contain a catalytic motif, suggesting that they are all active enzymes. However, their specific roles are not yet fully understood. All three families belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism.	7.13665e-56
NC_022663.1\|WP_023369989.1\|3780800_3781604_+\|nucleoside-phosphorylase	gnl\|CDD\|350158	cd09007, NP-I_spr0068, uncharacterized subfamily of the nucleoside phosphorylase-I family. This subfamily is composed of uncharacterized members including Streptococcus pneumoniae hypothetical protein spr0068. The nucleoside phosphorylase-I (NP-I) family members accept a range of purine nucleosides as well as the pyrimidine nucleoside uridine. The NP-1 family includes phosphorolytic nucleosidases such as purine nucleoside phosphorylase (PNP, EC. 2.4.2.1), uridine phosphorylase (UP, EC 2.4.2.3), and 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP, EC 2.4.2.28), and hydrolytic nucleosidases such as AMP nucleosidase (AMN, EC 3.2.2.4) and 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase (MTAN, EC 3.2.2.16). Members of the NP-I family display different physiologically relevant quaternary structures: hexameric (trimer-of-dimers arrangement of Shewanella oneidensis MR-1 UP); homotrimeric (human PNP and Escherichia coli PNPII or XapA); hexameric (with some evidence for co-existence of a trimeric form) such as E. coli PNPI (DeoD); or homodimeric such as human and Trypanosoma brucei UP. The NP-I family is distinct from nucleoside phosphorylase-II, which belongs to a different structural family.	3.196e-73

>NC_022663.1|WP_023369974.1|3771484_3772057_+|dCTP-deaminase
MLLSDRDLRAEISAGRLGIDPFDDSLVQPSSVDVRLDCLFRVFNNTRYTHIDPARQQDELTSLVEPATGDPFVLHPGEFVLASTLELFTLPDDLAGRLEGKSSLGRLGLLTHSTAGFIDPGFSGHITLELSNVANLPIALWPGMKIGQLCILRLTSPAEHPYGSSGVGSKYQGQRGPTPSRSYVNFIRST
>NC_022663.1|WP_036444000.1|3770739_3771396_+|hypothetical-protein
MGRHSLVRERRRSPAVLAAVLAPAAVFFAVAGDVGPLDARVVDQGDGPCCVEIVAATPLALVSRMPGSEAGMGLGGGQFAAASRWRVDTRSRALPPGAAPEQGLQVKTILVARSLSALFPEIHEIGGVRADALRWHPNGLALDVMIPDPGSADGIALGNQIVGYVLLNASRFGIQDAIWRGVYYTPEGARSTGAGHYDHVHITTTGGGYPTGEEIYLR
>NC_022663.1|WP_023369970.1|3769953_3770622_+|pyroglutamyl-peptidase-I
MSQVLVTGFGAYGNTPANPAQLTAEALDGRIIAGATVTARIVPNVFFESIAVTQQAIADVRPDLVVMLGEYPGRAVITVERLAQNINDCGRYGLADNAGTVLVGEQTDPAGPVAYHATVPIRAMVVAMRKAGVPADISDAAGTFVCNHLMYGVLHHIAKNGLPIRAGWIHLPCLPSVAALEHNLGAPSMSVETAVAGVAAGIEAAVRQLSDIGKPVRSRLQI
>NC_022663.1|WP_099184505.1|3769158_3769911_-|hypothetical-protein
MFDRTREVGISIVTTAASLVAFPVVAGIIGGVVAVVRSPSPALVSGVQHFAAGVVTAAVAGEVLPDLRARGSLWLIVVGFSAGVAVLVGLRHFDGDEGSGGEGSGGALPVAFLAVVAVDLFIDGLLVATGATVSRRTALIIALALTVEVLFLGLSVALRLTGSGVPRVRAAVTTGGVSLVTAVGAVLGALLLGGASAAVLTLVLAFAAAALLWLVVEELLVEAHETPERPWMAVMFFAGFLILYCLGVME
>NC_022663.1|WP_036396178.1|3767567_3768623_+|serine/threonine-protein-kinase
MTAATRAAGKIIAGRYEVRKALGSGAFGEVYEVFDHNLKQVCALKIHNRMVAGPWTEAQILRQLDGEYILKVLNADLAEGAPYVVTHLATNGTIADQIQPDVGVPITAAVRWARQACQGVARIHDQKLLHRDLKPENLFIDGRHDVLVGDLGLAQLQDENGLADAAGSIPTMAPEIARIGAPGQNPTTARVYSIAADVYSLGATLFWMLAGAQPVPGTSSYDDIWRASQPDLWEVAPHVPQGLRDIVNRSIAREPVKRYASAAGFDSALGGWSPPPRLWTRVKPHPGHEQCFSGTKGASLLAVCAIPTGVRTQLNIVAYHSASGRAVTKARRTVPRSGLSAGLRSAFHACN
>NC_022663.1|WP_023369964.1|3767302_3767518_+|transposase
MCWDNAQAESFWATLKVEFYDRCLWPTKAAAKLAVGDWIERVYNRRRRHSALAMMRPVEFEDRLIQTAQAA
>NC_022663.1|WP_023369962.1|3765849_3767049_-|tyrosine-type-recombinase/integrase
MDTTVSGIGAVVVAELRAAGYMESTVGQYAKTIKALTEFASGREYSTGLGVEFASMTTSVRTGRFSAQRRFDYRRLVTVFDSYVQTGRVDLAVRGRGGGGPRPVGGDFVALDATWEAEMGRRGLAPATREAYGRVARSYLVFLERRGIAVLDGADGASVLAFLESILDRWARSSLFWVVSNFRPFLKFTGRADLVNALNLAGVKRFHAIVPLLGDADEELVVRACASGVVSARDAAITLLALTTGLRACDIVALRIGDVDWRGHTIGIVQQKTGNPLTLPLPALLLGKLASYVLDERPSSGDDHLFLRMKAPHTRLNDHATVHRVTVETFRKAGVAEAKAGTRLLRHNAASRLLAAAVPLPTIAAVLGHASEESTNLYMSVDRRRLLDCVLPVPEAVRS
>NC_022663.1|WP_023369960.1|3764902_3765853_-|tyrosine-type-recombinase/integrase
MSGHGLTSAFATELDAYLAFKAKMGFTGASRIWYLKRFDAYCAEHDRTVFDKDTVEGWVAVQLQHSGRYRSWMSYIRDVGRWMAMNEIPGAYVLSDRWKAPIVAAHPYLLSRREIELFFAAAARVQTPCPWRWQAAAFFTLMHSCGLRTGETRALQTGQVDLDAGHIDIIWSKGHRGRRLPLTAEVVEILDTCDRTSRDHFASRRTFFVSATGNQVSAATVGKIFGRIWDQAGLDRPVAGQQPRPYDLRHHFAYANIQRWMTAGDDVTAMLPYLSRYMGHATFDSTYYYVHTSPDFMAAYADITRDRQSLLPQVGF
>NC_022663.1|WP_023369958.1|3763862_3764903_-|site-specific-integrase
MRRDPHTGAPDFFGVARDYLHSYIPKTRGLSPKTVEAYRISLECFLDYLAEAEHIGREHVSFDRFDRPHLKGWLAWMTDQRHYTPKTVTLRLSAIKAFLAYAAYEDLTLVALSQAAKALKAPAGPRRPVEYLTEAQTRAILAAFTGQTAKSRRNRMLLILLYDTAARVGEITGLTLGDLRLTEPGHILLTGKGNKTRVVPLTDKTIGHLHVYLDEFHPNITKLPARRPLFYSLHRGRPAELSADTVAAVLKQAAESARTQCPSIPANIHCHLLRKTKAMDLYQQGIPLPIIMRLLGHENASTTAAFYAFATLDMMRQAINAATPAINTAATEPLTEDQLQTLYSLR
>NC_022663.1|WP_142396053.1|3763439_3763649_-|transposase
MGQCQAESFWATLKVEFYDRCLWPTKAAAKLAVGDWIERVYNRRRRHSALAMMRPVEFEERLIQTAQAA
>NC_022663.1|WP_036396171.1|3773983_3775405_+|hypothetical-protein
MSMAPTAVRMVLVEGENGDGALVDQDQFDVSGDGDAATISAAQQVVSAILGTREGAYEGGYQLTSTGVTWRDPAQAAALREALANQKIEKVVLVSAFLAAAALAQAVGNETNYAHTALLFIEPETATLAVVDSADGSIADIQRQLLSDDDDTAVAQLTELVSAAESLETHPDAIFVVGSGIDIPMIKPALETATALPVTAAEEPDTALARGAALASANTPLFVSSTAALAYAQDPGTGALDPNRLDAAYFNDVSDSVQTGEGPLAYSAVPDSVVADSAVPDDQPERKPFPLLASIVTSIFVIGVAALALSLAVSIRSSTDVKPDPGHNVVTPSAPAPAAHAPAPKPQAPAPTPQAPTPQAPAPPEPAPAPQAPAPAPRAPAPAPQAPAPAPAPVPEAPAPAPAPAPVPAAPAPAPVPIPVPVQIPVPPIFGPGGGGGFPGGGDDGDDHGGGRGGGHGRGHGRGGFNIPFIPGL
>NC_022663.1|WP_023369980.1|3775481_3776831_+|UDP-glucose/GDP-mannose-dehydrogenase-family-protein
MRCTVFGTGYLGATHAVGMAELGHEVLGVDIDPGKVAKLAGGDIPFYEPGLRKLLTDNLTAGRLQFTTDYDLAADFADVHFLGVGTPQKRGEYGADLRHVHSVIDALVPRLTRASVLIGKSTVPVGTAAELGRRAAALTPRNVTVEIAWNPEFLREGFAVRDTLHPDRIVLGVQDDSTRAEEAVRELYGPLLQAGVPFLVTDLQTAELVKVSANAFLATKISFINAISEVCESAGADVSLLADALGYDPRIGRQCLTAGLGFGGGCLPKDIRAFMARAGELGANQALTFLREVDSINMRRRSRMVELATIACGGSLLGANIAVLGAAFKPESDDVRDSPALNVAGQLQLNGAAVNVYDPKALDNAHRLFPTLNYAVSVAEACERADAVLVLTEWREFVDLDPDDLADRVRARVIVDGRNCLDVARWERSGWRVFRLGARAPVGDTQNRA
>NC_022663.1|WP_023369982.1|3776968_3777646_+|metalloregulator-ArsR/SmtB-family-transcription-factor
MAGQSNRKAALLEQISRVGKALGNGRRLQILDLLAQGERTVEAIATATGMNLTTASANLQALKSGGLVEARRDGTRQYYRLAGDDVARLFALVQVVADEHLADVAVAAAAVLGSPEDAITREELLRRQKSGEVTLVDVRPHEEYQAGHIPGAINIPVAELAGRLAELPADRDIVAYCRGAYCVMAPDAVHIARTAGRAAMRLDDGMLEWRLAGLPVHEGEAVRTP
>NC_022663.1|WP_023369984.1|3777669_3778449_-|membrane-protein
MRRVLVVGYGAICYLIFVAAFLYAIGFVGNLLVPRTVDNGITASTSEAVVVNVVLLGLFAVQHSVMARPWFKSRWTRLVPATVERSTYVLLSSLLLFLLFWQWRTMPAVIWAVSWPPAKLLVLGLFWLGWIIVFTSTFMINHFDLFGLRQVYLAARARSYSHLEFRTTMLYRLVRHPIMLGFIVAFWATPTMTAGHLLFAVMTTGYILVALPLEEHDLSRALGDDYRRYRNRVPMLIPGLLLHRQRRTLHTGPAGTATK
>NC_022663.1|WP_023369985.1|3778681_3779350_+|class-I-SAM-dependent-methyltransferase
MFSAGQSDLAVEQREHWQDTYRAHPAMYGPGPSLPAGYALEVFQAAGANRVLELAAGQGRDSLHFARAGLQVLATDFSDVAVAQLRRTAHSQRLGGRVRAIVHDLREPLPVEIGSFDAVFAHMALCMALSTKEIHAVVAEVRRALKPGGKFIYTVRHTRDEHYGMGQCHGDDIFECGGFAVHFFSRELVASLADDWVLEDVSAFAEGELPRRLWRVTVAKPT
>NC_022663.1|WP_023369987.1|3779622_3780804_+|NAD(P)/FAD-dependent-oxidoreductase
MSKTIVILGAGVGGLTTADSLRQLLPPEDRIILVDRSFDGVLGLSLLWVLRGWRRPDEVRFRASPTSLPGVELVTATVGRIDVATRAVHTSNGVLGYDALVIALGATLDEAAVPGLAKALQAGVAGQFYTLDGAMELHTKVDALDRGRIAVLVAAVPFKCPAAPFEAAFLMAAQLGDRFASGAVRIDTFTPDPLPMPVAGPEVGQALVAMLEDRGIGFHGRKAVTAVDPADRTLHFGDGTTESFDLLAVVPPHVPSAAARSAGLGESGWIPVDPQALTTRVDGVWAIGDATVLTLPNAKPLPKAAVFAQSQAGVVAHGVARHLGYDVPERLFTGEGACYVETGDHQAAKGAGNFLRAPAPSVTLYPPSVAFHEEKVAQESAWLDRWNTRTSPP
>NC_022663.1|WP_023369989.1|3780800_3781604_+|nucleoside-phosphorylase
MTDDQGRYPLVTPKAFDEPSVFRPANLLREARRQKSLPDKPVPAVCVLDPDGDVVRHLARAGTGYRHPGWACYHTEMWVVEVDGLEIGVVGMAVGAPFAVLVAEQLAVSGAALVVSITSAGRISGNETPPYFVLIERALRDEGTSAHYVAPGEWSYLAAGLKDKLRNAFGQNGIYVVTGSSWTTDAPYRETALAIKEAKRRGIACVEMEAAALYAYAAAAGRNVVCLAHITNTMAVDGDDFEKGSDNGVNVSLAVVSAVATAILGSP
>NC_022663.1|WP_023369991.1|3781824_3782070_+|DUF4190-domain-containing-protein
MSSLAINGFAIAALAMSALGLLYVSIPLGIVALYQIARRRQQGREFAIAALVISAWWLSSLIAIAVAILLVWLTRPVRQPR
>NC_022663.1|WP_036396187.1|3782158_3782914_+|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme
MDYTSAYLDQTREFGDLIRNADQSTPVPSCPGWNLGQLFRHVGRGDRWAAQIVRDRLDSFLDPRSVEEGKPPPDMDDAITWLRGGAQRLVDAVERTGTETPVWTFLGARPAGWWIRRRLHEVAVHRVDAAIAIGSEFTLEPDIAADGISEFLERIATQAGRDDADLPLQAGDTLHLHATDPGLGAAGEWTVGVDEGRITWSHEHGKGTVALRGSAAELLLAMVRRVPVADTGIEVFGDPAVWRKWLDGTPL
>NC_022663.1|WP_023369995.1|3782925_3783300_+|nuclear-transport-factor-2-family-protein
MTTSEIATVLAWHDALNAGDVETLVSLSSDDIDIGDAHGAVQGHEALRRWAGSVMVAAELGQMYVHDGVVVVEQEITGRDDPGAVTTTASAFRVVRDHVTAVFRHDDLASALAATELTDDDLVD

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Crispr_ID: NC_022663_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022663_11

3913169-3913276

Orphan

Consensus_repeat	Method
TTGTGTGGCAGTGGTTTCCAGTGTGCAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022663_11

>merge|NC_022663|11|3913169-3913276|CRISPRCasFinder
TTGTGTGGCAGTGGTTTCCAGTGTGCATTTATGGCGGTGTGACGTGTAGGGCGAGCATTTGCCGATGGAGTGCAGTTTGGTTGTGTAGCAGTGGTTTCCAGTGTGCAT

>NC_022663|11|10|3913169-3913276|CRISPRCasFinder
TTGTGTGGCAGTGGTTTCCAGTGTGCAT	TTATGGCGGTGTGACGTGTAGGGCGAGCATTTGCCGATGGAGTGCAGTTTGG
TTGTGTAGCAGTGGTTTCCAGTGTGCAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_022663.1\|WP_023370203.1\|3908366_3909539_+\|acetate-kinase	unknown	unknown	gnl\|CDD\|234680
NC_022663.1\|WP_023370231.1\|3922604_3923126_-\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_023370213.1\|3913505_3915890_-\|protein-kinase	unknown	unknown	gnl\|CDD\|319004
NC_022663.1\|WP_036394677.1\|3903464_3904148_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|379312
NC_022663.1\|WP_023370205.1\|3909500_3910682_-\|DUF1501-domain-containing-protein	unknown	unknown	gnl\|CDD\|226587
NC_022663.1\|WP_023370215.1\|3915889_3916876_-\|glutamate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270408
NC_022663.1\|WP_023370199.1\|3905268_3906279_+\|glucose-6-phosphate-dehydrogenase-(coenzyme-F420)	unknown	unknown	gnl\|CDD\|213827
NC_022663.1\|WP_023370217.1\|3916875_3918195_-\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_023370189.1\|3900915_3902031_+\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274646
NC_022663.1\|WP_080674251.1\|3921863_3922601_+\|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|238861
NC_022663.1\|WP_023370201.1\|3906286_3908377_+\|phosphate-acetyltransferase	unknown	unknown	gnl\|CDD\|235537
NC_022663.1\|WP_023370197.1\|3904278_3905043_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293807
NC_022663.1\|WP_023370219.1\|3918379_3919003_+\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|239217
NC_022663.1\|WP_023370209.1\|3912205_3913063_+\|DUF559-domain-containing-protein	unknown	unknown	gnl\|CDD\|380141
NC_022663.1\|WP_023370225.1\|3920870_3921068_+\|sulfur-carrier-protein-ThiS	unknown	unknown	gnl\|CDD\|135627
NC_022663.1\|WP_036394680.1\|3921069_3921825_+\|thiazole-synthase	unknown	unknown	gnl\|CDD\|234687
NC_022663.1\|WP_103799443.1\|3918974_3919634_-\|thiamine-phosphate-synthase	unknown	unknown	gnl\|CDD\|234590
NC_022663.1\|WP_023370207.1\|3910678_3911989_-\|DUF1800-domain-containing-protein	unknown	unknown	gnl\|CDD\|378055
NC_022663.1\|WP_023370223.1\|3919851_3920874_+\|glycine-oxidase-ThiO	unknown	unknown	gnl\|CDD\|274092
NC_022663.1\|WP_023370191.1\|3902027_3903362_+\|NtaA/DmoA-family-FMN-dependent-monooxygenase	unknown	unknown	gnl\|CDD\|274819

Protein	Function_ID	Function_description	E-value
NC_022663.1\|WP_023370203.1\|3908366_3909539_+\|acetate-kinase	gnl\|CDD\|234680	PRK00180, PRK00180, acetate kinase A/propionate kinase 2; Reviewed.	0
NC_022663.1\|WP_023370213.1\|3913505_3915890_-\|protein-kinase	gnl\|CDD\|319004	pfam16918, PknG_TPR, Protein kinase G tetratricopeptide repeat. This domain is found at the C-terminus of protein kinase G and contains a tetratricopeptide repeat (TPR).	0
NC_022663.1\|WP_036394677.1\|3903464_3904148_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	3.53468e-18
NC_022663.1\|WP_023370205.1\|3909500_3910682_-\|DUF1501-domain-containing-protein	gnl\|CDD\|226587	COG4102, COG4102, Uncharacterized protein conserved in bacteria [Function unknown].	1.43244e-45
NC_022663.1\|WP_023370215.1\|3915889_3916876_-\|glutamate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270408	cd13690, PBP2_GluB, Substrate binding domain of ABC glutamate transporter; the type 2 periplasmic binding protein fold. This group includes periplasmic glutamate-binding domain GluB from Corynebacterium efficiens and its related proteins. The GluB domain belongs to the type 2 periplasmic binding protein fold superfamily (PBP2), whose many members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	6.79858e-106
NC_022663.1\|WP_023370199.1\|3905268_3906279_+\|glucose-6-phosphate-dehydrogenase-(coenzyme-F420)	gnl\|CDD\|213827	TIGR03554, F420_G6P_DH, glucose-6-phosphate dehydrogenase (coenzyme-F420). This family consists of the F420-dependent glucose-6-phosphate dehydrogenase of Mycobacterium and Nocardia. It shows homology to several other F420-dependent enzymes rather than to the NAD or NADP-dependent glucose-6-phosphate dehydrogenases. [Energy metabolism, Pentose phosphate pathway].	0
NC_022663.1\|WP_023370189.1\|3900915_3902031_+\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|274646	TIGR03558, oxido_grp_1, luciferase family oxidoreductase, group 1. The Pfam domain family pfam00296 is named for luciferase-like monooxygenases, but the family also contains several coenzyme F420-dependent enzymes. This protein family represents a well-resolved clade within family pfam00296 and shows no restriction to coenzyme F420-positive species, unlike some other clades within pfam00296. [Unknown function, Enzymes of unknown specificity].	5.76786e-107
NC_022663.1\|WP_080674251.1\|3921863_3922601_+\|SGNH/GDSL-hydrolase-family-protein	gnl\|CDD\|238861	cd01823, SEST_like, SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles two of the three components of typical Ser-His-Asp(Glu) triad from other serine hydrolases, but may lack the carboxylic acid.	2.89065e-46
NC_022663.1\|WP_023370201.1\|3906286_3908377_+\|phosphate-acetyltransferase	gnl\|CDD\|235537	PRK05632, PRK05632, phosphate acetyltransferase; Reviewed.	0
NC_022663.1\|WP_023370197.1\|3904278_3905043_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293807	cd07721, yflN-like_MBL-fold, uncharacterized subgroup which includes Bacillus subtilis yflN; MBL-fold metallo hydrolase domain. This subgroup includes the uncharacterized Bacillus subtilis yflN protein. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) from which this fold was named are only a small fraction of the activities which are included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	2.15861e-48
NC_022663.1\|WP_023370219.1\|3918379_3919003_+\|NUDIX-hydrolase	gnl\|CDD\|239217	cd02883, Nudix_Hydrolase, Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ for their activity. Members of this family are recognized by a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolase include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance and "house-cleaning" enzymes. Substrate specificity is used to define child families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required. This superfamily consists of at least nine families: IPP (isopentenyl diphosphate) isomerase, ADP ribose pyrophosphatase, mutT pyrophosphohydrolase, coenzyme-A pyrophosphatase, MTH1-7,8-dihydro-8-oxoguanine-triphosphatase, diadenosine tetraphosphate hydrolase, NADH pyrophosphatase, GDP-mannose hydrolase and the c-terminal portion of the mutY adenine glycosylase.	4.48199e-15
NC_022663.1\|WP_023370209.1\|3912205_3913063_+\|DUF559-domain-containing-protein	gnl\|CDD\|380141	pfam18741, MTES_1575, REase_MTES_1575. Vsr REase Fold. Fused to HEPN (SWT1/Abi2 family), along with Transglutaminase and wHTH.	2.62642e-07
NC_022663.1\|WP_023370225.1\|3920870_3921068_+\|sulfur-carrier-protein-ThiS	gnl\|CDD\|135627	PRK05863, PRK05863, sulfur carrier protein ThiS; Provisional.	2.51372e-29
NC_022663.1\|WP_036394680.1\|3921069_3921825_+\|thiazole-synthase	gnl\|CDD\|234687	PRK00208, thiG, thiazole synthase; Reviewed.	1.30704e-153
NC_022663.1\|WP_103799443.1\|3918974_3919634_-\|thiamine-phosphate-synthase	gnl\|CDD\|234590	PRK00043, thiE, thiamine phosphate synthase.	6.51828e-82
NC_022663.1\|WP_023370207.1\|3910678_3911989_-\|DUF1800-domain-containing-protein	gnl\|CDD\|378055	pfam08811, DUF1800, Protein of unknown function (DUF1800). This is a family of large bacterial proteins of unknown function.	4.08141e-108
NC_022663.1\|WP_023370223.1\|3919851_3920874_+\|glycine-oxidase-ThiO	gnl\|CDD\|274092	TIGR02352, Glycine_oxidase, glycine oxidase ThiO. This family consists of the homotetrameric, FAD-dependent glycine oxidase ThiO, from species such as Bacillus subtilis that use glycine in thiamine biosynthesis. In general, members of this family will not be found in species such as E. coli that instead use tyrosine and the ThiH protein. [Biosynthesis of cofactors, prosthetic groups, and carriers, Thiamine].	3.19142e-105
NC_022663.1\|WP_023370191.1\|3902027_3903362_+\|NtaA/DmoA-family-FMN-dependent-monooxygenase	gnl\|CDD\|274819	TIGR03860, FMN_nitrolo, FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family. This model represents a distinctive clade, in which all characterized members are FMN-binding, within the larger family of luciferase-like monooxygenases (LLM), among which there are both FMN- and F420-binding enzymes. A well-characterized member is nitrilotriacetate monooxygenase from Aminobacter aminovorans (Chelatobacter heintzii), where nitrilotriacetate is a chelating agent used in detergents. [Unknown function, Enzymes of unknown specificity].	2.36331e-161

>NC_022663.1|WP_023370209.1|3912205_3913063_+|DUF559-domain-containing-protein
MWDSQAPFLGSEALACRALTRHQLRTHYRAVLPNVYLSRRAQVSLEQRIAAAWLWSRGSAVIAGAAAAALHGAKWIPDDFPVELICRNSRPPHGVLTRRDVLGDGEIQTVDGRAVTTPERTAFDIGRRGAVRSAVVRLDALARATGFKVDDVLCVAARHPGARGVRQLEIALELVDSGAQSPRESYLRLLLIDAGFPRPRSQIAVSGADGMPIAYLDLGWEDYMVAVEYDGDHHQRDRQQYVKDIRRIEMLEQLGWIVIRVVAEDRPADILRRVQAAMAERSSIV
>NC_022663.1|WP_023370207.1|3910678_3911989_-|DUF1800-domain-containing-protein
MAGQSARWITTARVLRRAGFGASGREVDAVAGQDWPAHLDDILAADPDADPGARETPMPVLPTPRPRAKKATPAMREEFKRELAEQQAVLTGWWLRRMVAVRQPLREKLTLLWHNHFATSARKVRVPAYLAAQNQKLRTLALGDFRTLAYAMLTDAAMLRWLDGQSNTAKAANENLAREFMELFALGHGNGYTEDDVRAGARALTGWVIGTGGHTMMLPRRHDFTAKTLFGATGNFDAAGFCDAVLAQPKSAQHVAGRLWQQLAADEPPPPAVLDRLVSAYGPNRDLRALTRAVLTDEEFTGGRATVVTTPVEWLVGVIRSLRVPIDNHLKLIETTLKVLGQRPFFPPDVGGWPKGQVWLSTASAGTRLRTALHLANTADLSTVENTAAQDRIDAVGYLIGVGAWSDRSARALAPLVRRPPQLVAAAVNTPEYLTS
>NC_022663.1|WP_023370205.1|3909500_3910682_-|DUF1501-domain-containing-protein
MINRRRFLIASAGAGAAGLLSGAVAVSWRDLQHAAHDRPLPDDAGVLVIVTLYGGNDGINTVIPYADNAYHDARPELAYTAGDVVQLDAQLGLNPGLRGLTQLWQQRQLAIVRGVGYPKPDHSHFRSMDIWQTASPAEPASTGWIGRWLDATGDDPLRAVNIGAVLPPLAVGEKHTAAALSTNPATQANDRFDATMQALSATDPDDTPAMAAVSRSYRDARTTDAAFASIKTDGSHNSLATQLNMVAAAVKGRVPARVYTVQLGGFDTHADERDTQQRLLQTFDEAVTGFLREMAGDRCGRNIVILAYSEFGRRVAANASQGTDHGTAGPVFVAGVPVNGGYYGDEPSLTDLDRGDLKSTTDFRDIYHELLVHTLATDPTPSVGTGRTSLGFL
>NC_022663.1|WP_023370203.1|3908366_3909539_+|acetate-kinase
MTGSRLVLVLNSGSSSLKFQLIDPVSGMSRAAGNIERIGEASSSVRDHDAALRRAFDMLSEDGIDVATCGLMAVGHRVVHGGKDFHRPTVLDDAVVARLEELSVLAPLHNPPALLCIKVARTMLGDIPHVAVFDTAFFHDLPAAAATYAIDRELAEAWQIRRYGFHGTSHRNVSEQAAAFLGRPLETLNQIVLHLGNGASASAIAAGRPVDTSMGLTPLEGLVMGTRSGDVDPSIMWYLWRTANMGVDEIESMLNHRSGILGLAGERDFRRLHQLIEQGDLAARLAYDVFIHRLRKYIGAYLAVLGHTDALTFTAGIGEHDAAVRRDALAGLGELGLELDAGRNAAPAGGARQISTDDSPIAVLVIPTNEELAIARDCLQETQAGPAGSD
>NC_022663.1|WP_023370201.1|3906286_3908377_+|phosphate-acetyltransferase
MSSSSPGTTAIYIAAPEPASGKATIALGILHRLTATVAKVGVFRPLTRASGARDYLLELLLEHTTAGLPYEQCVGVTYQYLHADTDTAITDIVAAYHAMAHKCDAVVIVGSDYTDVATPTELSVNARIAVNLGVPVLLAVNAKGRTADQVVSVVGVCLAELSAHHAHTAAVVANRCEPAELAAIREALRIVGPPSYALPEEPLLSAPTVAELERAVDGTAISGEAPLRNREVMDVLVAGMTADHVLERLGEGMAVITPGDRSDVVLAVASAHAAEGFPSLSCIVLNGGFDLHPSIAALVSGLRLRLPIIATTLGTYETASAAAAARGRLTATSQRKIDTALELMDRHVDTADLMTHLAIPIPTVTTPQMFTYGLQQRARSNRKHIVLPEGDDDRILKSAGRLLQRGIAELTILGDEARIRARAAELGVDLGQAKVLDPRTSPLCDHFAEQYAELRKSHGITAELAREIMCDVSYFGTMLVYNSHVDGMVSGAAHTTAHTVRPALEIIRTAPGISTVSSIFLMCLPDRVLAYGDCAIVPNPTPEQLADIAICSARTAAQFGIEPRVAMLSYSTGASGTGADVEKVREATELVRSREPQLLVEGPIQYDAAVDPAVAAAKMHDSPVAGRATVLIFPDLNTGNNTYKAVQRSAGAIAIGPVLQGLRKPVNDLSRGALIEDIVNTVAITAIQAQGIGDDR
>NC_022663.1|WP_023370199.1|3905268_3906279_+|glucose-6-phosphate-dehydrogenase-(coenzyme-F420)
MAELKLGYKASAEQFAPRELVELGVAAEAHGMDSATVSDHFQPWRHKGGHAPFSLSWMTAVGERTKRVLLGTSVLTPTFRYNPAVIAQAFATMACLYPDRVFLGVGTGEALNEIATGYEGAWPDFKERFARLRESVRLMRELWRGDRVDFDGEYYRLKGASIYDVPEGGVPVYIAAGGPAVAKYAGRAGDGFICTSGKGAELYTEKLIPGVLEGAAAANRNTDDIDKMIEIKISYDPDPELALQNTRFWAPLSLTAEQKHSIDDPIEMEKAADALPIEQIAKRWIVASDPDEAVEKVGQYVTWGLNHLVFHAPGHDQLRFLQLFETDLAPRLRRLG
>NC_022663.1|WP_023370197.1|3904278_3905043_-|MBL-fold-metallo-hydrolase
MAHHLKTELVQVTDKVQLAHGQAVNWVLVTDDTGVMLIDAGYPGDREEVLASLRLLGYQPGDVRAILLTHAHIDHLGTAIWFAREHHTPVYCHADEVGHAKREYLEQVSLLDIALRIWRPRWAVWAAHVARSGGLVRDGIPTAQPLTAEVAAQLPGHPMAVFTPGHTNGHCSYLVDGVLASGDALITGHPLLRRDGPQLLPAIFSYSQQNCIRSLSALALLETEILAPGHGELWRGPIRGATDEALKRAGAFAR
>NC_022663.1|WP_036394677.1|3903464_3904148_+|methyltransferase-domain-containing-protein
MSSSTTVPGVSVVTQDGSAVEIYRRMPSLGEIEHIQSLLTPNSSVLELGAGTGRIADALAALGHRVTAVDDSPEMLAHIRRARAIQARIEDARLGEKFDAVLLVSNLINYPDAQLRRSMLATVAHHLRPGGQAIIEWVPPSMLASRQEGWTKTLTFDGAEAALTIHSNAGGIVTGEFTLTADGRRWHQSLVLQRVSPATVRDELTAAGLTLTTAAPNSTRWLLAKRR
>NC_022663.1|WP_023370191.1|3902027_3903362_+|NtaA/DmoA-family-FMN-dependent-monooxygenase
MSRRPIHLAAHFPGVNNTTVWADPDAGSQIEFDSFVHLARTAERGLFDFFFLAEGLRLREHRGRIYDLDVVGRPDTFTVLAALAGVTDRIGLTGTINTTFNEPFEVARQFATLDHLSDGRAGWNIVTSSDAFTGANFRRGGFLDHGDRYARAEEFLTVARKFWDSWAPGAVLADVENGVYVDPGRIGSIEYSGTHFDVRGFATLPAGPQGHPVLLQAGDSAEGRAFAARHADAVFTLHASLQDAQRYYADMKGRARSYGRDPNRLKVFPAVTVVIGDTGTEAQDKARHIRRQQVSGATAIAMLEQVWGRDLSGYDPDGPLPDVEPIADSAVSQGRVRHVDTVALARRYRDKAAAENLSIRELVIAVTSRQQFVGTAAHIADEMDRYVQADACDGFILVPHLTPHGLDEFVDRVVPLLQARGAFRTEYAGATLREHLGLGPGARV
>NC_022663.1|WP_023370189.1|3900915_3902031_+|LLM-class-flavin-dependent-oxidoreductase
MIPLSVLDLSPISAGSDAATALRNTVELAQQAERCGYRRFWIAEHHFVAVASAAPAVLIGQIAAATNRIRVGSAAVQLSHTTAAAVVESFGMLDAFYPGRIDLGLGRSAQRRGIKPRDPAKPRAPRPPVEWREVDGVVIPPPFDLRTLLASGRVQATMAILQQPEAVAPDFAEQVGDIIAMLAGTYRVDDFEVHAVPGEGAALTPWIFGSSKGRSAALAGAMGLPFVASYHLTPATALEAVDAYRAAFVPSVYLPQPYVVVSADVVVADDTATARHLAASYGHWVYSIRAGGGAIPYPDPADCAPLTEEQRAVVIDRLATQFVGNPDEVAQRLHALQRVTGADELVITSVTHRHQDRLRSHELIAHRWGLM
>NC_022663.1|WP_023370213.1|3913505_3915890_-|protein-kinase
MSPKPAHNDSAADDQEGRQDLAPGTQSADVQTGAAPGSRPLQSADVQTGAAPGSRPLQSADVQTGAAAGSRPPATQAIFRPDFDDDDDDLPISLGAMDTQPQERMSAATRALPPIRKLGGGLVEIPRVPDIDPLKALMTDPVVPESKRFCWNCGRPVGRSDAEGTGASEGWCPYCGSPYSFLPQLCAGDIIAGQYEVKGCIAHGGMGWVYLALDHNVNDRPVVLKGLVHSGDAEAQAIAMAERKFLAEVVHPSIVQIFNFVEHTDRQGDPVGYIVMEYIGGQSLRRGRGEKLPVAEAIAYILEILPALSYLHSIGLVYNDLKPENIMLTEEQLKLIDLGAVSRINSFGYLYGTPGFQAPEIVRTGPTVATDIYTVGRTLAALTLNLPTRNGRYADGLPDDDPVLDKYDSFGRLLRRAIDPDPRRRFASTEEMSAQLTGVLREVVAADTGVPRPGLSTIFSPSRSTFGVDLLVAHTDVYLDGQVHAEKLTAKEIVTALQVPLVDPTDVAAPVLQATVLSQPVQTLDSLRAARHGALDAEGVDLSESVELPLMEVRALLDLGDVAKATRKLDDLAERVGWRWRLIWYKAVAELLTGDYDSAIKHFTEVLDTFPGELAPKLALGATAELAGYTDEHNFYQTVWQTNDGVISAAFGLARALSAKGDRAGAVRTLDEVPPSSRHFTTARLTSAVTLLSGRSQGEITEEQIRDAARRVESLPPTEPRVLQIRALVLGGAMDWLQDNQASTNHILGFPFTDHGLRLGVEAALRSLARIAPTQRHRYTLVDMANNVRPTSTF
>NC_022663.1|WP_023370215.1|3915889_3916876_-|glutamate-ABC-transporter-substrate-binding-protein
MKGLPSFSRAASPLALLAAAVLLAGCGHSESLKVETTPTLPYPTPVGMEVMPPEPPLPPDTASQDCNPTASLRPFRTKAEADAAVANIHERGRLIVGLDIGSNLFSFRDPITGDITGFDVDIAGEVARDIFGSPSHVEYRILSAAERITALQTSQVDVVVKTMTITCERRKLVNFSTVYLDANQRILAPRDSSISKVSDLSGKRVCVARGTTSLRRIREIAPPPVIVSVVNWADCLVAMQQRQIDAVSTDDSILAGLVEEDPYLHIVGPDMANQPYGIGINLDNTGLVRFVNGTLERIRTDGTWNTLYRKWLSVLGPAPVPPQPRYLD
>NC_022663.1|WP_023370217.1|3916875_3918195_-|hypothetical-protein
MTVELAHPSTEPLGLRSPAEPAHPRWWFVSTTPGRILTIGIVLAALGVSSAFATSTTINHRQQVLTTVLEHTEPLSFAAGRLYTTLSVADAAAATAFIAQAEPRAVRLRYEQAITDAAVAVTRASSGLTDESLVQLLGRINAELAVYTGLIEIARTNNRAGNPVGSSYLSEASGLMQTTILPDAQQLYQATSERVDTETTASTQIPAPVILVVTTTVVFGAFSHRWLARRTRRRINPGLIVGALGILVMVVWVGTALTISTAASRSAKDTAAESLKTVTNLAITAQQARADETLSLIRRGDEEIRKQSFYQRIEAMHHQLDDYMARRDAVDKPDLQGADQLLVRWQQANDRINSYISVGNYRAAIQVALGKGEDDATPAFDKLDEALTKAMEQSRNRLRNDVLNARRGLAGAQVGGVVLSVGAAIAVALGLWPRLKEYR
>NC_022663.1|WP_023370219.1|3918379_3919003_+|NUDIX-hydrolase
MQGDGDGWVVSDDGAHYWGRFGSAGLLLRAPLPDGGPAVLLQHRAVWSHQGGTWGLPGGARDSHETPEQTAVREAREEAGLAAQRLVVRSVLVTARPRGTAWTYTTVVADTDELLHTVPNRESAELRWVAEDDVTDLPLHPGFAASWQLLRTAPVTVPLHRGDERRRRLPCTVVIEDGVFVWCMPGDADLAPSQLSPRVSSLLEALT
>NC_022663.1|WP_103799443.1|3918974_3919634_-|thiamine-phosphate-synthase
MARLAEARLYLCTDARRERGDLAEFADAALAGGVDIIQLRDKGSAAEQRLGPLEALDELAACEILVDAARRHGALFAVNDRADIAAAAGADVLHLGQRDLPSSIAREIVGPGVLIGRSTHDRDQVAAAAVGDADYFCAGPCWPTPTKPGRPAPGLDLVRAAAAIGGDKPWFAIGGIDAPRLPEVIAAGARRIVVVRAITAADDPKAAAQQLRSALPAAS
>NC_022663.1|WP_023370223.1|3919851_3920874_+|glycine-oxidase-ThiO
MSAPTPAGSLAVIGGGVIGLSVARRAARAGWSVRVHRGGEHGASWVAGGMIAPHSEGWPGEERLLRLGLESLRLWHDGGFLDGLPSHVVTARESLVVAVDRADVADLRTVADWLSQQGHPVVWESAARDVEPLLAQGIRHGFRAPTELAVDNRALLDALTVDCERLGVAWAAPVTGLSDAEGDVVVIANGIDAPALWPGLPVRPVKGEVLRLRWRKGCMPLPRRVIRARVHGRQVYLVPRADGVVVGATQYEHGRDTAPVVSGVRDLLDDACAVLPVLGEYELAECSAGLRPMTPDNLPIVQRLDARTLVAAGHGRSGFLLAPWTAEQIMCELAAVGASA
>NC_022663.1|WP_023370225.1|3920870_3921068_+|sulfur-carrier-protein-ThiS
MIVVVNEQQVEVDEQTTVAALLQSLGFPDRGVAVALDCALLPRSDWATMLSEGDRLEVVTAVQGG
>NC_022663.1|WP_036394680.1|3921069_3921825_+|thiazole-synthase
MGDKLTIGDRSFASRLIMGTGGASNLAVLQEALVASGTELTTVAIRRVDAEGGTGLLDLLNRLGITPLPNTAGCRSAAEAVLTAQLAREALDTNWVKLEVIADERTLLPDAIELVRAAEQLVDDGFVVLPYTNDDPVLARRLEDAGCAAVMPLGSPIGTGLGITNPHNIEMIVAQAGVPVVLDAGIGTASDAALAMELGCDAVLLATAVTRAADPPAMAAAMAAAVTAGHLARRAGRIPKRFWAQASSPEL
>NC_022663.1|WP_080674251.1|3921863_3922601_+|SGNH/GDSL-hydrolase-family-protein
MAAGPGIRPRADGAPWRSGRSARNYPHLVAEQQRLKLVDVTYSGATTANVLGDHQHGAPPQITALDGSESLVTVTIGGNDVGYIPLLMAAALPRPARRLPLLGAWIAELLDRNSRDQALAQVFDSLCEVGRSLRRRAPRSRVLFVDYLTLLPPAGVPAPPLSAAHSELGRHVAATLERLTADAAALTGCEVVRAAAASRDHHAWSPEPWTEKPARFGVPLPARPAPLHPNAAGMRAVAKLVAAQL
>NC_022663.1|WP_023370231.1|3922604_3923126_-|hypothetical-protein
MSHFTTALRAATAAALMASLACLGTATANADPTGTASDVNTLAGSVSKGYGLNNCAAQTITSGELAALSCGQNPDAAGPALAKYILFATPDDMNGSFKASIKDETLTACGDSGQSPTTWRQGSAGATAGQVACGTYQGAAEIIWTTDAKNVLSYIRAGNSDVPALYQWWRTNG

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Crispr_ID: NC_022663_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022663_12

4484175-4484273

Orphan

Consensus_repeat	Method
CTGCGCGGCGCCGACCTGAGCGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022663_12

>merge|NC_022663|12|4484175-4484273|CRISPRCasFinder
CTGGCGGGTAACGACCTGCGCGGCGCCGACCTGAGCGGCTGCCGGCTGCGCGAGACCAGCCTGGTGGAGGCCGACCTGCGCAAGGCCGTGCTGCGCGGG

>NC_022663|12|11|4484175-4484273|CRISPRCasFinder
CTGGCGGGTAACGACCTGCGCGGC	GCCGACCTGAGCGGCTGCCGGCTGCGCGAGACCAGCCTGGTGGAGGCCGAC
CTGCGCAAGGCCGTGCTGCGCGGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_022663.1\|WP_023371248.1\|4474977_4476759_-\|PE-family-protein	unknown	unknown	gnl\|CDD\|376422
NC_022663.1\|WP_036391603.1\|4470944_4474247_+\|error-prone-DNA-polymerase	unknown	unknown	gnl\|CDD\|235553
NC_022663.1\|WP_036391606.1\|4477582_4478599_+\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197666
NC_022663.1\|WP_023371270.1\|4489537_4492174_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224054
NC_022663.1\|WP_023371278.1\|4495433_4496618_-\|NADH:flavin-oxidoreductase	unknown	unknown	gnl\|CDD\|239201
NC_022663.1\|WP_023371260.1\|4482938_4483322_+\|DUF742-domain-containing-protein	unknown	unknown	gnl\|CDD\|283084
NC_022663.1\|WP_023371246.1\|4474332_4474977_+\|nitroreductase-family-protein	unknown	unknown	gnl\|CDD\|380311
NC_022663.1\|WP_036391034.1\|4487047_4489510_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224054
NC_022663.1\|WP_023371250.1\|4476901_4477366_-\|tRNA-(cytidine(34)-2'-O)-methyltransferase	unknown	unknown	gnl\|CDD\|223297
NC_022663.1\|WP_023371256.1\|4479826_4482535_+\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|340391
NC_022663.1\|WP_023371282.1\|4497511_4497805_+\|DUF3017-domain-containing-protein	unknown	unknown	gnl\|CDD\|378602
NC_022663.1\|WP_023371274.1\|4492683_4493934_+\|YcaO-like-family-protein	unknown	unknown	gnl\|CDD\|273224
NC_022663.1\|WP_023371258.1\|4482531_4482963_+\|roadblock/LC7-domain-containing-protein	unknown	unknown	gnl\|CDD\|224929
NC_022663.1\|WP_036391031.1\|4478626_4479295_-\|GAF-and-ANTAR-domain-containing-protein	unknown	unknown	gnl\|CDD\|377145
NC_022663.1\|WP_023371284.1\|4497829_4498222_-\|DUF732-domain-containing-protein	unknown	unknown	gnl\|CDD\|368380
NC_022663.1\|WP_023371280.1\|4496657_4497515_+\|bifunctional-methylenetetrahydrofolate-dehydrogenase/methenyltetrahydrofolate-cyclohydrolase	unknown	unknown	gnl\|CDD\|237637
NC_022663.1\|WP_023371276.1\|4493930_4495385_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226013
NC_022663.1\|WP_023371262.1\|4483302_4483893_+\|ATP/GTP-binding-protein	unknown	unknown	gnl\|CDD\|225138
NC_022663.1\|WP_023371266.1\|4484448_4486989_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224054
NC_022663.1\|WP_023371286.1\|4498438_4499872_+\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223354

Protein	Function_ID	Function_description	E-value
NC_022663.1\|WP_023371248.1\|4474977_4476759_-\|PE-family-protein	gnl\|CDD\|376422	pfam00934, PE, PE family. This family named after a PE motif near to the amino terminus of the domain. The PE family of proteins all contain an amino-terminal region of about 110 amino acids. The carboxyl terminus of this family are variable and fall into several classes. The largest class of PE proteins is the highly repetitive PGRS class which have a high glycine content. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	2.12364e-30
NC_022663.1\|WP_036391603.1\|4470944_4474247_+\|error-prone-DNA-polymerase	gnl\|CDD\|235553	PRK05672, dnaE2, error-prone DNA polymerase; Validated.	0
NC_022663.1\|WP_036391606.1\|4477582_4478599_+\|AraC-family-transcriptional-regulator	gnl\|CDD\|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	5.45565e-20
NC_022663.1\|WP_023371270.1\|4489537_4492174_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	3.38035e-67
NC_022663.1\|WP_023371278.1\|4495433_4496618_-\|NADH:flavin-oxidoreductase	gnl\|CDD\|239201	cd02803, OYE_like_FMN_family, Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as electron acceptors in the catalytic reaction. Members of OYE family include trimethylamine dehydrogenase, 2,4-dienoyl-CoA reductase, enoate reductase, pentaerythriol tetranitrate reductase, xenobiotic reductase, and morphinone reductase.	5.82555e-112
NC_022663.1\|WP_023371260.1\|4482938_4483322_+\|DUF742-domain-containing-protein	gnl\|CDD\|283084	pfam05331, DUF742, Protein of unknown function (DUF742). This family consists of several uncharacterized Streptomyces proteins as well as one from Mycobacterium tuberculosis. The function of these proteins is unknown.	7.98889e-29
NC_022663.1\|WP_023371246.1\|4474332_4474977_+\|nitroreductase-family-protein	gnl\|CDD\|380311	cd02062, Nitro_FMN_reductase, nitroreductase family protein. Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.	4.04745e-27
NC_022663.1\|WP_036391034.1\|4487047_4489510_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	3.38103e-66
NC_022663.1\|WP_023371250.1\|4476901_4477366_-\|tRNA-(cytidine(34)-2'-O)-methyltransferase	gnl\|CDD\|223297	COG0219, CspR, Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis].	3.32414e-77
NC_022663.1\|WP_023371256.1\|4479826_4482535_+\|HAMP-domain-containing-protein	gnl\|CDD\|340391	cd00075, HATPase, Histidine kinase-like ATPase domain. This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.	9.54191e-17
NC_022663.1\|WP_023371282.1\|4497511_4497805_+\|DUF3017-domain-containing-protein	gnl\|CDD\|378602	pfam11222, DUF3017, Protein of unknown function (DUF3017). This bacterial family of proteins with unknown function appear to be restricted to Actinobacteria.	1.51988e-13
NC_022663.1\|WP_023371274.1\|4492683_4493934_+\|YcaO-like-family-protein	gnl\|CDD\|273224	TIGR00702, Uncharacterized_protein_Rv1375/MT1419, YcaO-type kinase domain. This protein family includes YcaO and homologs that can phosphorylate a peptide amide backbone (rather than side chains), as during heterocycle-forming modifications during maturation of the TOMM class (Thiazole/Oxazole-Modified Microcins) of bacteriocins. However, YcaO domain proteins also occur in contexts that do not suggest peptide modification. [Hypothetical proteins, Conserved].	1.94166e-123
NC_022663.1\|WP_023371258.1\|4482531_4482963_+\|roadblock/LC7-domain-containing-protein	gnl\|CDD\|224929	COG2018, COG2018, Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only].	1.19979e-31
NC_022663.1\|WP_036391031.1\|4478626_4479295_-\|GAF-and-ANTAR-domain-containing-protein	gnl\|CDD\|377145	pfam03861, ANTAR, ANTAR domain. ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the domain consists of a coiled-coil.	5.5921e-16
NC_022663.1\|WP_023371284.1\|4497829_4498222_-\|DUF732-domain-containing-protein	gnl\|CDD\|368380	pfam05305, DUF732, Protein of unknown function (DUF732). This family consists of several uncharacterized Mycobacterium tuberculosis and leprae proteins of unknown function.	3.33542e-22
NC_022663.1\|WP_023371280.1\|4496657_4497515_+\|bifunctional-methylenetetrahydrofolate-dehydrogenase/methenyltetrahydrofolate-cyclohydrolase	gnl\|CDD\|237637	PRK14193, PRK14193, bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional.	0
NC_022663.1\|WP_023371276.1\|4493930_4495385_+\|hypothetical-protein	gnl\|CDD\|226013	COG3482, COG3482, Uncharacterized conserved protein [Function unknown].	4.67156e-70
NC_022663.1\|WP_023371262.1\|4483302_4483893_+\|ATP/GTP-binding-protein	gnl\|CDD\|225138	COG2229, COG2229, Predicted GTPase [General function prediction only].	2.63673e-62
NC_022663.1\|WP_023371266.1\|4484448_4486989_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.77794e-66
NC_022663.1\|WP_023371286.1\|4498438_4499872_+\|FAD-binding-oxidoreductase	gnl\|CDD\|223354	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion].	5.53885e-41

>NC_022663.1|WP_023371262.1|4483302_4483893_+|ATP/GTP-binding-protein
MASKHSEAHLRDTAAHASTKIVIAGGFGAGKTTFVGAVSEIMPLRTEAMVTDASVGVDMLEVTPQKQTTTVAMDFGRITLGEDLVLYLFGTPGQRRFWFMWDDLVRGAIGAIVLVDCRRLEDSFAAVDFFEHRNLPFLVAVNEFDGAPRYPAAEVRQALTLPAHIPVINIDARSRRSATDALIAVSEYALASLTGS
>NC_022663.1|WP_023371260.1|4482938_4483322_+|DUF742-domain-containing-protein
MDRREPPLARPGANLVRPYTLTAGRTGTDIDLPLEAAVQALPAGSAHRWPPHDMRGRIIRLCADSPSSPSVAEIAARLDLPVGVARVLVGDLVSSDYLRVQATLTDRSTSDERRELIGRTLRGLQAL
>NC_022663.1|WP_023371258.1|4482531_4482963_+|roadblock/LC7-domain-containing-protein
MNTRSLDSPLDWLVSKFAREVPGVAHALLVSVDGLPLAASEYLPRERADQLAAVASGLASLATGAAQLFEGGQVLQSVVEMQNGFLLLMRVGDGSHLATLAVTGCDIGQIGYEMAILVERVGSVVQSSRRAQPEPQWTDASRR
>NC_022663.1|WP_023371256.1|4479826_4482535_+|HAMP-domain-containing-protein
MTMFARPTTPVAAVPPEVRGAQRRPARHRPAAWSLSNWPVGWKVVAIAVVPLLLATVFGVLRIDAAMANSGNLRLVAARANVIPAITKYMSALDVALLASSTGRDVEGAKKNFTARKYELQTRLADTDVIPDVRSGVNTLLNGGQALLDKVLENSIGLRDRITTYAPLLLTAEDAINASVRVDSEQIRAQVQGLSRAVGARGQMTMQEILVTRGADLPEPQLRTSMITLAGTEPSTLFGMSEVLGVGSPDAKNLQQQLLTRMAIMSDPASELVDNPELLRSIKVTDGIAEQVIKGATASVTNSVQAQATARRDAAVRDAVLVLAAIAIALVVVLLVARALVRPLRVLRDGALKVAHTDLEGEIARVRAGAEPQPQPLAVYTTEEIGQVAHAVDELHTQALLLAGDEARLRLLVNDMFETMSRRSRSLVDQQLSLIDRLERNEQDPDRLDSLFRLDHLAARLRRNSANLLVLAGAEISRERREPVPLPTVVSAAVSEVEDYRRVAVGGVADCKVIGGAAGSVIHLLAELIDNALSYSPPTTTVRVSAVRGSAGGVLLRVADCGLGMTDSDRRIANMRLQSGGEVTPDNARHMGLFVVGRLAARHGIRVGLRGPSTGEAGNGTTAEVYLPVAVLAGGESPASQAGAPAPTPRPFIIKPPTPEPAADPAATSSYQNGADKPVPPVTLLPRRKPGSSGITDIPAPPAGQQPRARRELKTPWWETRHDARHDAQRDAQQTPAQTPPTKQATASDTSAFFAQRSTAAAARPADPPPKPSVPAGPVDDDVIYQRMLSEMMGDPRELAASPDLDWRSVWDRGWSAAAQAQDKPVESRTDHGLPVRTPGARLVPGAAEPEPGVGPHPDRQPPAAAAVRDPDAVRASIGSHFGGVHTGRAHARTTSQEADQQ
>NC_022663.1|WP_036391031.1|4478626_4479295_-|GAF-and-ANTAR-domain-containing-protein
MYTVLSEVDELQRRGETDFESALRDINAITVASVPGAQYLGVTVVDTSGTIETLAATHRYPALLDDVQRDVREGPCLSAAWEQHTIRIDDLTTDGRWPRYRTAALDRTPVRSIMSFRLFGSDKALAALNFYADSTRAFDDESVELGLVFAAHTTVVWNLIRRQQQFRSALASRDLIGQAKGILMERFDINAVAAFELLRRLSQESNTKIVEIAEKLIELKRR
>NC_022663.1|WP_036391606.1|4477582_4478599_+|AraC-family-transcriptional-regulator
MSTGPAARSRPRPREPARESAPRELDFDSSDLAETEDFLVRTYTKMRISGEGRMCRARIQRRCLGSLSIDELSFSYDMGYDANPLGKILLCRVRRGRIEENFIGEPQHVLAAGELAMIGPPELPHSGRVRHAGYQLIGFDPALLDRVAPNAPDRAHEPVRLTGHRPVSVAAGNRLTALIDYLRDHILADPSAASAPLVIDTAAAHLAVATLNAFPHSALLDPTPTDRRDSAQPVLLRRAMAFIEENAHQDIALADIAAHVYVTPRALQYMFRQRLDCTPMQYLRRVRLDRAHRELLDSSRASATVKQIANRWGFIHIGRFAIYYRETYGRSPHATLRG
>NC_022663.1|WP_023371250.1|4476901_4477366_-|tRNA-(cytidine(34)-2'-O)-methyltransferase
MFKLMFVSPCIAPNTGNAIRTAAATGCELHLVEPLGFDLSEPKLRRAGLDYHDLASVTVHASLTAAWDALLPARVFAFTAQATTPFSDVSYRAGDVLMFGPEPTGLDAATLADAHITEQVRIPMLAGRRSLNLSNAAAVAVYEAWRQHDYSGAL
>NC_022663.1|WP_023371248.1|4474977_4476759_-|PE-family-protein
MSYLVAVPEAVSAAATKVAEFGAALRSANSSAAGATTGLLAAGGDEVSAAIASLFSTHGQAYQEVAAQMTAFHDRFVQALTAGAGAYAHAEAANASPLQTLEQDVFGAINAPTQALLGRPLIGDGAAGTATNPNGQDGGLLFGNGGAGYSQPAGSGLAGGNGGSAGLIGNGGIGGAGGAGAAGGAGGHGGWLTGNGGNGGVGGNAVLAGGSGGNGGAGGAAGLWGDGGTGGHGGAGLAGNNGVNPTPVTDPGLNGKPGDSNVPGPNGFETGTKGGDGTTGGAGINGGNGGDGGAANANFTTSFGAVGGAGGNGATGGYGGATGGAGGSGGPAASEFGPALGGNGGNGGDGGAGTNGQAGGAGGVGGAGGNGGWLVGNGGAGGAGGNGAIGGNGDIGGTGGAGGFNGVPGGNGAASTFAVASGGAGGNGGSGGTGGHGGHGGSGGTGGAGGAAGWLAGNGGSGGQGGSGGAGGVGGAGGTGIDGAPGATAFSEHYVTDGGDGGAGGNAGHGGTGGDGGDGGHGGAGGRSGLLSGQLGAAGIGGGGGIGGGGGTHGTPGNGGAGALGTDVSGFDGKAGLGGDAFNGVNGSNGKPG
>NC_022663.1|WP_023371246.1|4474332_4474977_+|nitroreductase-family-protein
MALNLTVDEVLTTTRSVRKRLDFDQPVPRDVLMECLELALQAPTGSNSQGWQWVFVEDAATKKAIADVYLTNARAYLSAPAPEYPEGDTRGERMGKVRNSATYLAEHMHEAPVLMIPCIQGREDQTPLGGVSFWASLFPAVWSFCLALRSRGLGSCWTTLHLLGDGERQVADLLGIPYDQYSQGGLFPIAYTKGTDFRPAKRLPTESLTHWNSW
>NC_022663.1|WP_036391603.1|4470944_4474247_+|error-prone-DNA-polymerase
MGWGNGPPSWAEMERVLDGKPRHAGAPVAAEPADDAGLEGPWSRQRGTYQPPENARVRSSAAYAELHAHTAYSFLDGASTPEELVEEAARLDLCALALTDHNGLYGAVRFAEAAAELDMRTVFGAELSLGSEARTEQPDPPGPHLLVLARGPEGYRRLSRQLAAAHLAGGEKGKPRYDFDALTEAAGGHWHILTGCRKGHVRQALSEGGPDAAQRALADLVDRFGAYRVSIELTHHGHPLDDERNATLAGLAPRFGVGVVATTGAHFAHPSRSRLAMAMGAIRARQSLDSAAGWLAPLGGSHLRSGDEMARMFAWRPEAVTAAAELGGQCAFELALIAPQLPPFDVPGGHTEDSWLRQLVMAGARHRYGPPDGAPRAYAQIGHELKVIAQLKFPGYFLVVHDITQFCRRNNILCQGRGSAANSAVCYALGITAVDPVANELLFERFLSPARDGPPDIDIDIESDRREKVIQYVYDKYGRDYAAQVANVITYRGRSAVRDMARALGFSQGQQDAWSKQISHWNGQAAEVDGIPEQVVDLATQIRNLPRHMGIHSGGMVICDRPIADVCPVEWARMENRSVLQWDKDDCAAIGLVKFDLLGLGMLSALHYAMDLVAEHKGLEVDLAKLDLSEPAVYEMLARADSVGVFQVESRAQMATLPRLRPRVFYDLVVEVALIRPGPIQGGSVHPYIRRRNGIDPVVYEHPSMAPALRKTLGVPLFQEQLMQLAVDCAGFTAAEADQLRRAMGSKRSTERMQRLRGRFYDGMRALHGTRDEVIDRIYEKLEAFANFGFPESHALSFASLVFYSAWFKLHHPAAFCAALLRAQPMGFYSPQSLVADARRHGVVVHGPDVNASLAHATLENAGMEVRLGLGAVRHIGDDLAEKLVGERNANGPFASLLDLASRVQLSVPQTEALATAGALGCFGMSRREALWAAGAAATQRPDRLPGVGAQGADGSHIPVLPGMSELELAAADVWATGISPDSYPTQFLRADLDAMGVLPADALGSVPDGDRVLIAGAVTHRQRPGTAQGVTFINLEDETGMVNVLCTPGVWARHRKLANTAPALLIRGQVQNASGAITVVAERLGRISLAVGSRSRDFR
>NC_022663.1|WP_023371266.1|4484448_4486989_-|ATP-binding-cassette-domain-containing-protein
MNTVAPPVLTVLGLGPQRTFAAGHDIIVGSDLRADMHVSHPSVSRAHLLLRFDHGRWMAIDNGSHEGTFVDHRRVHAVEIHPGQRINIGSPDGPCLTFEVGQPEVPAGRPPRTAPIPAAQLRPHPAARPVPPPAPGPIPAMEPAHPAPPTRLGRVHPGPQPPPTRMGPYLAPDPAPPRPPSHPPVPPRDPSNLATKVIRSLWPESGRNRRLAGAVTVGRAQDNDIVVPDVLASRRHAFLVQTALGTEIRDARSVNGTYVNGVRIGSAVLSEGDVVTIGNVDMVFSAGTLTRQADAGTPAGGLEVNRVQFEIDGKQLLDNISLTARPGTLTAIIGGSGAGKTTLARLIAGYTRPSAGSITFEGHDIHAEYATLRSRIGMVPQDDVVHRQLTVNQALGYAAELRLPPDTSSADRAKVVARVLEELELTEHGDTRVDKLSGGQRKRASVALELLTGPSLLILDEPTTGLDPALDSQVMMMLRKLADAGRTVVVVTHSVSYLDLCDQLLLLAPGGKTAYFGPPDQVGSVMGTSNWAHIFIKVGADPDEAKRRFLAQRGSEPKLSARAEPGDLGEPVHVDVWRQFSTVARRQVRLVVSDRWYTVFLAALPFMLGLLTLTVPGHSGFGVADPNGKTPAEPAQILVLLCVGAVFMGTALTIRDLVGERPIFHREQAFGLSTQAYLLAKIAVFSMFATAQAAIVTTIAVIGKGAPTRGAVLLGNPTLELFVAVAATCFASAIVGMGMSALARSSDQILPLLVVAIMAQLVFSSGIIPVTNRVVLDQLSWLTPARWGFAASASTIDLNTVQPSPFSPKDSHWHHTTGAWLLDMAMLGLLSTVYAGFVLWRIRLKR
>NC_022663.1|WP_036391034.1|4487047_4489510_-|ATP-binding-cassette-domain-containing-protein
MTRAQRPVLTVRSDRSQRSFAPGADAIVGSDLRADLRVAHPLVAQAHVVVRFEQGNWIAIDNSRTGMFVDGRRVPLVDIRDGLVVNLGRPDGPRISFEVGHHRGIIGLLPQTGFPPPGGPAAGTEQQQHRPPAQPPGPAPPAPGAPGYPGAQRTTVIPVSPPPPQAERTTTLNVAGAASGHAPTGAGISWIGRALDNDIVVADVLASRHHAFLTPTPVGTEINDAHSINGTFVNGIRVGSAILREGDVVTIGNVDLAFTGTTLVRRAEAATRTGGLEVTGISYTVNGAALLDNVSLTARPGTLTAVIGGSGAGKTTLSRLIAGYLSPTSGTVTFEGHNIHTEYASLRSRIGMVPQDDVVHRQLTINQALGYAAELRLPPDTSKQDRAQVVAGVLEELRLTEHADTRVDKLSGGQRKRASVALELLTGPSLLILDEPTSGLDPALDLQVMTMLRQLADAGRVVLVVTHSLTYLDVCDQVLLMAPGGKTAFLGPPDQIGQAMGTTNWAQIFAKVGADPDEANRRFLARNQPPAPAPIETPTDLGEPAHTSVRRQFSTIARRQVRLVVADRAYFTFLAALPFVLGALSLTVPGDTGFGMAQPTSQTPDEAAQILTLLSIAAVFMGTALTIRDLIGERAIFRREQAVGLSTRAYLGAKITVFCMFAITQAAITTGVVLLGKGVPTQQAVLLGNPSFELFTTVAATCVASAILGLLLSSVARSSEQIMPLLVVSLMLQLVLAGGLVPVTNRLFLDQLSWAVPARWGYAASAATVNLRELVPGSYSPEDSHWTHSRPAWLFDMAMLATLSVAYACLVWWRIRLRRH
>NC_022663.1|WP_023371270.1|4489537_4492174_-|ATP-binding-cassette-domain-containing-protein
MPQSAPPALTVRYDGSARTFAPGHDVVVGRDLRADMRITHPLISRAHLLLRFDQGRWLAIDNNSLNGTFCNGRRVPMVDIQDGQSVNIGNPDGPLLTFEVGRHVGMAGRPPQTESMRVGTQSSPWPPAATQVAGHPGPPPPARQSNWTAPPSARPHPGPPPKSGQPMYPSSASRQPGFAPGPPRQPSNQPPNQPPNYAPAGPRPSPPTQMQPSAAKPPEVANLATKMIHALLPRTGSNEMPAGSVTIGRATDNDVVIQDVLASRHHAFLTMTPLGTEIRDAHSVNGTFVNGVRVGSAILSDGDVVTIGNVDLVFTGGTLIRRTEAATRTGGLEVKSVCFKADGKQLLDHISLTARPGTLTAIIGGSGAGKTTLSRLIAGYTSPSSGTVTFEGHNIHTEYASMRSRIGMVPQDDVVHRQLTVNQALGYAAELRLPPDTSKADRDQVVAQVLEELELTKHADTRVDKLSGGQRKRASVALELLTGPSLLILDEPTTGLDPALDRQVMMMLRQLADAGRVVLVVTHSVSYLDVCDQLLLVAPGGKTAFLGPPDQIGQAMGTTNWADIFAKVGADPDEANRRFLADKQAQPAFPSQASPAADLGEPVHTDVFRQFSTIARRQVRLVVSDRGYTVFLALLPFLIGVLSLTVRGKTGFGMSDPLGNNPAQPDQILVMLNVGAVFMGTALTIRDLIGERPIFRREQAVGLSTAAYMAAKIVVFSAFAIAQAAIATTICVIGWGKPLSDAVLLGDVRFELFVTVAATCVASAMLGMALSALAQSQDQIMPMLVFSIMSQLVFSGGMIWVTDRILLDQLSWATPARWGYAASASTIDTHRLVPGPTDPKDQHWDHKASAWLFDMAMLGVVSIAYTAIVWWRIRLRRR
>NC_022663.1|WP_023371274.1|4492683_4493934_+|YcaO-like-family-protein
MSESCAAATAASVGPDWSQWPTRVLGHANPTSIAHRAGTYRIMSPEQTWRAVQPMLELAGITRVADLTWLDDLGIPTVQAVRPASVTLSVSQGKAATYRAAQVSAVMESLETWHAENVTPDLFSMRTTDLAAALTYDPAHLLLSARSIYHPGAKLDWMTATTLLTGRQTWVPWEAVLVNAAVDNRWDPPMFSMDTTGLASGNSYWEASLHGLYEVMERHAMAAGEPGSTLFEVPVDDVADSGCAELVDMIYRAGSELKIARTDTWDGFPCFTAEICSPMLGVPFSGFGLHHDPNVALSRAITEAAQSRLTAISGAREDLSPALYHRFARVHAYGPLRPTMRHLPTAEPTPWHVPGTDSLSDLLASAATAVADRSGTEPLAVVCDLAGSCVPVVKVIAPGLTASHGSPMRTPLQESA
>NC_022663.1|WP_023371276.1|4493930_4495385_+|hypothetical-protein
MRAARRIVVTAGPTIGVADVHTVVPNAEVVPPISFGDALRYGLKPGDTLLIVDGLFFQHPPVRHKELLTLIQDGVRVVGSSSMGALRAAELHPFGMEGYGWVFDNYRNGYLEADDEVAMVHGEPEDGYPVFVDALVNIRQTLARAVETGLLSAQLAADLVETAGRTPFTMRTWDRLLAALEVPERSCLAKQLTASRVDIKHADAVVALRNIVDGQDGVATRPGPPPTVWSVRWKQRWEPPVPVAITSGTDTDTGTTLGVRDTDVLSLLSICAADRWAYLPALEQVASWYWIVTHPGDHGDVRQHASRAVAQVAAGTRRRALETVAHRYAVAIGLADESGFPASVRSQWLTDEENATLGTDPIAVSALLVTRTLFVTRSLPAIEHFLDLLRADPRLPHWRSVTAQALARRDELARRKPHLNLHRPDPRQLKNLFAKRWGAEVDRIELARRGLMSEEAFYTAATLFAVAAADDRLPSIEVGALGPA
>NC_022663.1|WP_023371278.1|4495433_4496618_-|NADH:flavin-oxidoreductase
MPDAPDVLGPAKLGPLTLRNRVIKAATFEARTPDALVTDDLIEYHRLPAAGGVGMTTVAYCAVSPGGRTSGDGMWMRPEAVPGLRRLTDAVHAEGAAVSAQIGHAGPVADARSNKATALAPVRFFNPIAMRFAKKATRDDIADVTAAHANAARLAVDAGFDAVEIHLGHNYLASSFLSPLINRRDDEFGGSLENRAKVARGLVLAVRHAVQQQIAVTAKLNMADGIRGGITTEEALTTAKWLQDDGGLDALELTAGSSLVNPMYLFRGDAPVKEFAGAFKPPLRWGIRMTGHKFLREYPYRDAYLLRDARLFRAELSMPLILLGGITNRETMDLAMAEGFDFVAMARALLAEPDLVNRIAAEGQRARSACTHCNLCMPTIYSRTRCVVTGAPDR
>NC_022663.1|WP_023371280.1|4496657_4497515_+|bifunctional-methylenetetrahydrofolate-dehydrogenase/methenyltetrahydrofolate-cyclohydrolase
MGAIMLDGKATRDEIFVDLKRRVAALTSSGSASGRPPGLGTILVGDDPGSHAYVRGKHADCAKVGITSIRRDLPADISTATLNETIDELNANSDCTGYIVQLPLPKHLDENAALERVDPGKDADGLHPTNLGRLVLNTPAPLPCTPRGIVHLLRRYDVELAGAHVVVIGRGVTVGRPLGLLLTRRSENATVTLCHTGTRDLAALTRQADIIVAAVGVPHMLTADMVRPGAAVVDVGVSRTDDGLVGDVHPDVWEVAGHVSPNPGGVGPLTRAFLLTNVVELAEQR
>NC_022663.1|WP_023371282.1|4497511_4497805_+|DUF3017-domain-containing-protein
MTARAILAHTFRAQWPILLVGLIFTVAFVLVGANFWRRGALLIGIGVGVAAALRLALSDELAGLLVVRSKGTDFTTMAVVGAAMVYIASTIDPLGTG
>NC_022663.1|WP_023371284.1|4497829_4498222_-|DUF732-domain-containing-protein
MRTWRHQPLTIRLLAGSAVLLTAAAALAAPAEAGTIDDAFIGALNDAGVNYGDPASAVDLGHSVCSTLARPGGSFNSAAATVVAAGTGMPQPMAQIFTSIAISTYCPQAMTDVATGNLPGLPQIPGIPGF
>NC_022663.1|WP_023371286.1|4498438_4499872_+|FAD-binding-oxidoreductase
MISRQAFLRGAVGALATSAVFGHVRAAADPSSGWTGLASSIGGRVLLPDSGGSFTSGKQIFNSLYNGSNPAAVVTVTSQADVEKAVAFAAANKLKIAPRGGGHSYIGASAAAGAMVIDLRGLTGGVNFDSATGNVTMPAATDLYAVQQALAGAGRAIPTGSCPTVGVGGLTLGGGMGADSRHAGLTCDALRSATVVLPGGETVTASADDHPDLFWALRGGGGGNFGVTTSMTFATFPTADSDVVRVDFAPSSAAQVLTGWQTWLAAADRNTWGLVDMSVSASQANCHVLATCPAGSGPAVANAIKSAVGVQPTGVEHKTLSHMDLVMYLAGGSATSSPRSFVAGSDVIGTMNSAAAQSIVAALGKWPPASGRASVIVDTLSGAVGDVDPSGSAFPWRRQSAVAQWYVETPGSGQVAAANKWIGAAHQAVQQFSVGAYVNYLEPNTAPARYFGPNLARLTAIRQRYDPGQLMYSGIVF

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Crispr_ID: NC_022663_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022663_13

4888195-4888442

Orphan

Consensus_repeat	Method
CGCCGACGGCGACACCAACATCGCCACCTTCGCCA	PILER-CR

3 spacers

The CRISPR arrays of NC_022663_13

>merge|NC_022663|13|4888195-4888442|PILER-CR
CGCCGTCGGCAACACCAACATCGCCACGTTCAGCAACGTAATCGGCAACGCCAACAGCGGCATCGCAACCAGCACCGATGGCGATACCAACATCGCCACCTTCGCGACCGTGGTCGGCAACGGCAACCATGGGGCTGGCGCCGATGCCGTCGGCCGCCTCAACATCGCCACCTTCGGCACTGCAGTCGGCGGCGGGAACGAGGTCGGCGCGAGCGCCAACGGCGACACCAACATCGCTACCTTCGCCA

>NC_022663|13|1|4888195-4888442|PILER-CR
CGCCGTCGGCAACACCAACATCGCCACGTTCAGCA	ACGTAATCGGCAACGCCAACAGCGGCATCGCAACCAGCACC
GATGGCGATACCAACATCGCCACCTTCGCGACCGT	GGTCGGCAACGGCAACCATGGGGCTGGCGCCGATGCCGTCGGCCGCCTCAAC
ATCGCCACCTTCGGCACTGCAGTCGGCGGCGGGAA	CGAGGTCGGCGCGAGCGCCAACGGCGACACCAAC
ATCGCTACCTTCGCCA

Protein	Signature genes	Signature genes Name	Protein_function
NC_022663.1\|WP_023371914.1\|4882734_4883268_-\|YceI-family-protein	unknown	unknown	gnl\|CDD\|377274
NC_022663.1\|WP_023371924.1\|4898006_4899215_-\|CoA-transferase	unknown	unknown	gnl\|CDD\|367110
NC_022663.1\|WP_023371927.1\|4901850_4903776_+\|PPE-family-protein	unknown	unknown	gnl\|CDD\|369775
NC_022663.1\|WP_023371921.1\|4895243_4896482_-\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173838
NC_022663.1\|WP_023371925.1\|4899211_4900393_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|366166
NC_022663.1\|WP_023371907.1\|4877071_4877791_-\|NADH-quinone-oxidoreductase-subunit-C	unknown	unknown	gnl\|CDD\|181115
NC_022663.1\|WP_023371911.1\|4879554_4880250_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|226472
NC_022663.1\|WP_023371908.1\|4877787_4878342_-\|NADH-quinone-oxidoreductase-subunit-B	unknown	unknown	gnl\|CDD\|235797
NC_022663.1\|WP_023371920.1\|4894281_4895247_-\|phosphotransferase-family-protein	unknown	unknown	gnl\|CDD\|270703
NC_022663.1\|WP_023371926.1\|4900394_4901498_-\|homogentisate-1,2-dioxygenase	unknown	unknown	gnl\|CDD\|226039
NC_022663.1\|WP_023371919.1\|4893946_4894285_-\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_023371923.1\|4897113_4898010_-\|hydroxymethylglutaryl-CoA-lyase	unknown	unknown	gnl\|CDD\|163676
NC_022663.1\|WP_023371913.1\|4881456_4882719_+\|PPE-family-protein	unknown	unknown	gnl\|CDD\|366325
NC_022663.1\|WP_023371922.1\|4896493_4897114_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_022663.1\|WP_023371912.1\|4880246_4880870_-\|DedA-family-protein	unknown	unknown	gnl\|CDD\|223659
NC_022663.1\|WP_023371910.1\|4879023_4879425_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_022663.1\|WP_036391794.1\|4883392_4883794_-\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|378915
NC_022663.1\|WP_036444274.1\|4884236_4886216_+\|PPE-domain-containing-protein	unknown	unknown	gnl\|CDD\|366325
NC_022663.1\|WP_023371928.1\|4903785_4904757_-\|NADPH:quinone-oxidoreductase-family-protein	unknown	unknown	gnl\|CDD\|176203
NC_022663.1\|WP_023371909.1\|4878390_4878768_-\|NADH-quinone-oxidoreductase-subunit-A	unknown	unknown	gnl\|CDD\|181171

Protein	Function_ID	Function_description	E-value
NC_022663.1\|WP_023371914.1\|4882734_4883268_-\|YceI-family-protein	gnl\|CDD\|377274	pfam04264, YceI, YceI-like domain. E. coli YceI is a base-induced periplasmic protein. The recent structure of a member of this family shows that it binds to poly-isoprenoid. The structure consists of an extended, eight-stranded, antiparallel beta-barrel that resembles the lipocalin fold.	7.14033e-36
NC_022663.1\|WP_023371924.1\|4898006_4899215_-\|CoA-transferase	gnl\|CDD\|367110	pfam02515, CoA_transf_3, CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	4.63897e-152
NC_022663.1\|WP_023371927.1\|4901850_4903776_+\|PPE-family-protein	gnl\|CDD\|369775	pfam08237, PE-PPE, PE-PPE domain. This domain is found C terminal to the PE (pfam00934) and PPE (pfam00823) domains. The secondary structure of this domain is predicted to be a mixture of alpha helices and beta strands.	6.82461e-82
NC_022663.1\|WP_023371921.1\|4895243_4896482_-\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173838	cd00567, ACAD, Acyl-CoA dehydrogenase. Both mitochondrial acyl-CoA dehydrogenases (ACAD) and peroxisomal acyl-CoA oxidases (AXO) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. In contrast, AXO catalyzes a different oxidative half-reaction, in which the reduced FAD is reoxidized by molecular oxygen. The ACAD family includes the eukaryotic beta-oxidation enzymes, short (SCAD), medium (MCAD), long (LCAD) and very-long (VLCAD) chain acyl-CoA dehydrogenases. These enzymes all share high sequence similarity, but differ in their substrate specificities. The ACAD family also includes amino acid catabolism enzymes such as Isovaleryl-CoA dehydrogenase (IVD), short/branched chain acyl-CoA dehydrogenases(SBCAD), Isobutyryl-CoA dehydrogenase (IBDH), glutaryl-CoA deydrogenase (GCD) and Crotonobetainyl-CoA dehydrogenase. The mitochondrial ACAD's are generally homotetramers, except for VLCAD, which is a homodimer. Related enzymes include the SOS adaptive reponse proten aidB, Naphthocyclinone hydroxylase (NcnH), and and Dibenzothiophene (DBT) desulfurization enzyme C (DszC).	3.94776e-102
NC_022663.1\|WP_023371925.1\|4899211_4900393_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	9.24652e-07
NC_022663.1\|WP_023371907.1\|4877071_4877791_-\|NADH-quinone-oxidoreductase-subunit-C	gnl\|CDD\|181115	PRK07785, PRK07785, NADH dehydrogenase subunit C; Provisional.	1.25775e-155
NC_022663.1\|WP_023371911.1\|4879554_4880250_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|226472	COG3963, COG3963, Phospholipid N-methyltransferase [Lipid metabolism].	3.12188e-20
NC_022663.1\|WP_023371908.1\|4877787_4878342_-\|NADH-quinone-oxidoreductase-subunit-B	gnl\|CDD\|235797	PRK06411, PRK06411, NADH-quinone oxidoreductase subunit NuoB.	7.87269e-101
NC_022663.1\|WP_023371920.1\|4894281_4895247_-\|phosphotransferase-family-protein	gnl\|CDD\|270703	cd05154, ACAD10_11_N-like, N-terminal domain of Acyl-CoA dehydrogenase (ACAD) 10 and 11, and similar proteins. This subfamily is composed of the N-terminal domains of vertebrate ACAD10 and ACAD11, and similar uncharacterized bacterial and eukaryotic proteins. ACADs are a family of flavoproteins that are involved in the beta-oxidation of fatty acyl-CoA derivatives. ACAD deficiency can cause metabolic disorders including muscle fatigue, hypoglycemia, and hepatic lipidosis. There are at least 11 distinct ACADs, some of which show distinct substrate specificities to either straight-chain or branched-chain fatty acids. ACAD10 is widely expressed in human tissues and highly expressed in liver, kidney, pancreas, and spleen. ACAD10 and ACAD11 are both significantly expressed in human brain tissues. They contain a long N-terminal domain with similarity to phosphotransferases with a Protein Kinase fold, which is absent in other ACADs. They may exhibit multiple functions in acyl-CoA oxidation pathways. ACAD11 utilizes substrates with carbon chain lengths of 20 to 26, with optimal activity towards C22CoA. ACAD10 may be associated with an increased risk in type II diabetes. The ACAD10/11-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).	1.07571e-64
NC_022663.1\|WP_023371926.1\|4900394_4901498_-\|homogentisate-1,2-dioxygenase	gnl\|CDD\|226039	COG3508, HmgA, Homogentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism].	4.64335e-27
NC_022663.1\|WP_023371923.1\|4897113_4898010_-\|hydroxymethylglutaryl-CoA-lyase	gnl\|CDD\|163676	cd07938, DRE_TIM_HMGL, 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain. 3-hydroxy-3-methylglutaryl-CoA lyase (HMGL) catalyzes the cleavage of HMG-CoA to acetyl-CoA and acetoacetate, one of the terminal steps in ketone body generation and leucine degradation, and is a key enzyme in the pathway that supplies metabolic fuel to extrahepatic tissues. Mutations in HMGL cause a human autosomal recessive disorder called primary metabolic aciduria that affects ketogenesis and leucine catabolism and can be fatal due to an inability to tolerate hypoglycemia. HMGL has a TIM barrel domain with a catalytic center containing a divalent cation-binding site formed by a cluster of invariant residues that cap the core of the barrel. The cleavage of HMG-CoA requires the presence of a divalent cation like Mg2+ or Mn2+, and the reaction is thought to involve general acid/base catalysis. This family belongs to the DRE-TIM metallolyase superfamily. DRE-TIM metallolyases include 2-isopropylmalate synthase (IPMS), alpha-isopropylmalate synthase (LeuA), 3-hydroxy-3-methylglutaryl-CoA lyase, homocitrate synthase, citramalate synthase, 4-hydroxy-2-oxovalerate aldolase, re-citrate synthase, transcarboxylase 5S, pyruvate carboxylase, AksA, and FrbC. These members all share a conserved triose-phosphate isomerase (TIM) barrel domain consisting of a core beta(8)-alpha(8) motif with the eight parallel beta strands forming an enclosed barrel surrounded by eight alpha helices. The domain has a catalytic center containing a divalent cation-binding site formed by a cluster of invariant residues that cap the core of the barrel. In addition, the catalytic site includes three invariant residues - an aspartate (D), an arginine (R), and a glutamate (E) - which is the basis for the domain name "DRE-TIM".	1.49947e-120
NC_022663.1\|WP_023371913.1\|4881456_4882719_+\|PPE-family-protein	gnl\|CDD\|366325	pfam00823, PPE, PPE family. This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	1.0117e-49
NC_022663.1\|WP_023371922.1\|4896493_4897114_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.3356e-15
NC_022663.1\|WP_023371912.1\|4880246_4880870_-\|DedA-family-protein	gnl\|CDD\|223659	COG0586, DedA, Uncharacterized membrane-associated protein [Function unknown].	7.48874e-27
NC_022663.1\|WP_023371910.1\|4879023_4879425_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	0.00136066
NC_022663.1\|WP_036391794.1\|4883392_4883794_-\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|378915	pfam12680, SnoaL_2, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	0.000216441
NC_022663.1\|WP_036444274.1\|4884236_4886216_+\|PPE-domain-containing-protein	gnl\|CDD\|366325	pfam00823, PPE, PPE family. This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	6.45138e-74
NC_022663.1\|WP_023371928.1\|4903785_4904757_-\|NADPH:quinone-oxidoreductase-family-protein	gnl\|CDD\|176203	cd08241, QOR1, Quinone oxidoreductase (QOR). QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR acts in the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site, and a structural zinc in a lobe of the catalytic domain. NAD(H)-binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	1.5887e-132
NC_022663.1\|WP_023371909.1\|4878390_4878768_-\|NADH-quinone-oxidoreductase-subunit-A	gnl\|CDD\|181171	PRK07928, PRK07928, NADH dehydrogenase subunit A; Validated.	7.35513e-73

>NC_022663.1|WP_036444274.1|4884236_4886216_+|PPE-domain-containing-protein
MNFSVLPPEINSVRIFAGAGPQPMLAAATAWDGLAGELAGAASSFSSVASGLVDGSWRGPASAAMAAAAAPYARWLSAAAGHASGAAAQARAVARAFDAARAATVHPLMVAINRNRFVQLVASNVLGLNAPAIASAEAQYEQMWAQDVVAMLGYHADTSAAAAALSPWGAGPQGNSAGSGQSGTSEMPASGRGPVASAISAGSSAAAGTNISLSNLGFGNTGNGNFGSGNAGDLNLGSGNNGNVNLGSGNNGNVNFGSGNTGNVNLGSGNAGSLNAGSGNAGNNNLGSGNNGDANLGHGNVGSNNFGSGNIGGGNLGFGNAGSNNFGSGNNGSGNLGSGNGGNLNVGFANTGNNNIGFANTGNNNIGIGLTGDNQIGFGGLNSGTGNVGLFNSGSGNTGIFNSGSNNLGWLNSGVGNWGGWNSGMGSTGFGNSGVTSTGFWNSGSYDTGFGNAGSGNAGAFNAGSHNTGWFNSGSGSTGDYNSGDGNFGSFNAGDVNTGSFNAGSVNTGLWNSGHTNTGALNSGTLNTGFGSSIIQTVANSGFGNTGTGNSGFNNFGDNNSGYGNAGVAGGPGQNNAGIGNQGTLHSGIGNTGSNNDSGFGNTGFYNVGFFNTGDNNSGFGNINDVASGFNSGIGNFGNSNSGGFNIGTGWAGFFGSNF
>NC_022663.1|WP_036391794.1|4883392_4883794_-|nuclear-transport-factor-2-family-protein
MPSSTTEAIAEVADRLFTAIENSDRAAVARMWSDDIAVWRAGAHRDDDKARALRVIDWFVSATAERRYEVLDRQIFEDGSGRGFVQQHVLHAAGQTGQSIELRVCIVIKLDTEGLINRIDEYFDPAELAPLLG
>NC_022663.1|WP_023371914.1|4882734_4883268_-|YceI-family-protein
MTTLETLLSDPDAAGAWNLVPDRSAVTFKVKNMWGLLAVKGEFTKFVGRGNLTDQGTVSGYLEVDVASLRTGIRLRDKHLLSADFFEVERFPEIRVVVTALHPTKGKHAELQASFTIKGITDPVTLPVTVTEFSDGSVRIAGETEIDRVQFGLRWNKFGILAVTATASGEVCFVKAP
>NC_022663.1|WP_023371913.1|4881456_4882719_+|PPE-family-protein
MSFWVLPPEINSLRMFIGAGSAPMLQAATAWAGLADELGAAAQSFASVTSGLAGQAWQGPAAAAMAAAAAPYAAWLSAAAAQSAGAAGQARAMVSMFEAAQAATVLPAAVAANRDAFVQLVMSNLFGQNAPAIAFAESIYEEMWAADVSAMSGYYSGAAALASQLVPWQSILKGLPGMGSAGAAGTSAGSGAAGTTNVGGNGEGANVAGGDNAGGASGGPVGGETTNVVNSSTSAGLAQADPMYSNVGQGTAGSGNVGSASLLSGGTTSASGGVATPGMMGVPIPIPATGGNQTGSAGIGVGAGSAGNAAPTRVPEAAAPPAAEVEAAAPQLRVLPNADPEIAAKAAPVPVARVTQSTGSGIPESALRPSRTADVSHRSANTQDQASEAEEKVVSLRPEAEKGKLRPRAKQEPGIQMRGG
>NC_022663.1|WP_023371912.1|4880246_4880870_-|DedA-family-protein
METFILSHHSYLLLPLLTATGIPVPEEVVTVAAGALSSPSVGRLEPGLAILACLAGVLVGDCALYWIGRGLGQTHLGRYHWFARLVDSDRTGHVERILQQHGVKVFLLVRFLLGMRTPLYLAIGALKMDFRRFLVCDVVCATLAVGIFFLLSYLGAGWISGLIHRSEWAATAILLVTAVTGGLYYGVWKRWRVQLSAHGPRLQGKAQ
>NC_022663.1|WP_023371911.1|4879554_4880250_-|methyltransferase-domain-containing-protein
MTQQSPDTTLFFREFCGKFETTGSVMPSTRYLARAMTRHLRRRGPAPIRVLDCGPGTGAFTDRIVDHLRPGDRLDVVEINDSFVRVLQRRFATEPRWQAASNFTNIHEVPFQYFDAAEPYDFIISSLPHSNFPAITVAEILHSYTRLLKPGGVLTYVEYLYLRQIRRTLSRGTQRARIRSVEQLMLSHMSEHEVAHENVLRNVPPARVHHLIAPADGTGGNTGRDWNTLSA
>NC_022663.1|WP_023371910.1|4879023_4879425_-|response-regulator-transcription-factor
MPDSSDALRILVYSNNVQTRQQVMRALGKRLHPDLPELTYVEIATAPMVIQRMDEGGIDLAILDGEATPAGGMGIAKQLKDELSTCPPILVLTGRPDDSWLASWSRAEAAVSHPIDPIVLGRTALGLLRAPAL
>NC_022663.1|WP_023371909.1|4878390_4878768_-|NADH-quinone-oxidoreductase-subunit-A
MNVYIPILVLAALAAAFAVFSVVIASLAGPSRFNRSKLAAYECGIEPTDSSVSSPHATAGQRFPIKYYLTAMLFIVFDIEIVFLYPWAVSFDALGTFALVEMLIFMLTVFVAYAYVWRRGGLTWD
>NC_022663.1|WP_023371908.1|4877787_4878342_-|NADH-quinone-oxidoreductase-subunit-B
MGLEEQLPGGILLSTVEKVAGYVRKNSLWPATFGLACCAIEMMATAGPRFDLARFGMERFSATPRQADLMIVAGRVSQKMAPVLRQIYDQMAEPKWVLAMGVCASSGGMFNNYAIVQGVDHVVPVDIYLPGCPPRPEMLLHAILKLHEKIQEMPLGVNRERAIAEAEEAALLARPTIEMRGLLR
>NC_022663.1|WP_023371907.1|4877071_4877791_-|NADH-quinone-oxidoreductase-subunit-C
MSSPDQDPREAIARADEEVIDVRRGMFGVSGTGDTSGYGRLVRQVTLPGSSPRPYGGYFDDIADRLAEALHGEGVEFDDAIEKVVVYPQGEGAELTLHVRRERLPQVAQRLRDEPELRFEMCLGVNGVHYPHETGRELHAVYPLQSITHNRRLRLEVSVPDSDPHIPSLYSVYPTNDWHERETYDFFGIVFDGHPSLTRIEMPDDWHGHPQRKDYPLGGIPVEYKGAQIPPPDERRGYN
>NC_022663.1|WP_023371919.1|4893946_4894285_-|hypothetical-protein
MTGLHGRPTAAELVAAVADFLEGDVRAATSGQVNFHARVAANALRMVERELLSSGDAEVRTALADLGFADEAALAAAIRAGELDGRDEEVMACLRALVRHRLAVAHPGYDSE
>NC_022663.1|WP_023371920.1|4894281_4895247_-|phosphotransferase-family-protein
MTLLEDLAALLDPLLGAEVAIENLRVLTGGASRTTWAFDAVVGAERRPLILRIGPPDDVHAGMELEARVQAAAAAAGAPVPHILLADDSPAALGNPFLICEEVKGETIVRRIQRQLDDPGRTRLLRQCARALAAIHRAEWNGLGLVREDPLGQWRDRLDSMGDTTATFEWAFRWLRARRPPPSTAVLVHGDFRMGNLIVDGSDLAAVLDWELVHVGEAYEDLAWFCVRAWRFGAPASLGAGGLGSIESLLQAYEEAGGATVDRAAFRWWLVLATLRWGVICRYQAERHLSGRTRSVELAAIGRRVCENEWDLLELLEAVGR
>NC_022663.1|WP_023371921.1|4895243_4896482_-|acyl-CoA-dehydrogenase-family-protein
MDFSLPEHLPGLLAEMDEFIESDIKPLERQHIQYFDHRREHARTDWDNGGVPRREWEDLLAEMRRRADQAGWLRYGLPSRFGGRDGTNVDMAVIREHLAHKGLGLHNDLQNESSIVGNFPQVIMMDRFGTEAQKKEWTEALITGERSMAFGLTEPSHGSDATWLETRAERDGNSWVINGAKRFNTGVHRATHDLVFARTSGEPGQARGITAFLVPTDTPGFTVPYYWWTLNMPTDHGEVALEDVRVSGDAVLGEVDRGLEVGQTFLHENRIRQAASSLGAAQYCIDRAVDYANERRVFGKPLSVNQAVQWPLVELQTEAQMVRLLVYYAADQLDRNHHMEVSDKVAMANYRANRLVCEAADRAMQVFGGMGYSRHEPFEHIYRHHRRYRITEGAEEIQIRRVAQRLFKFGKK
>NC_022663.1|WP_023371922.1|4896493_4897114_-|TetR/AcrR-family-transcriptional-regulator
MAAGVLTAKGRQTRQAIEQAARKLFAERGFHGTTLADITSAAGKSPAVFYRYFSDKEDLLAALAESFLHDVVAPSGLSVHLPDTPDDDTFFTSVVTGYWNIFKQNIGIMIAVAQLAATQRRFAAVQNEFRRFGMDIVAASVRRAQEQGYGAELHPQHTAAAIALLFENFTTVFVGRSGPENLRLDISDEDAIKTLSMIWKKTLYGT
>NC_022663.1|WP_023371923.1|4897113_4898010_-|hydroxymethylglutaryl-CoA-lyase
MNQHVTIREVSLRDGLQIEKPIPLAAKLELLAAIAATGVREVEATAFVSPSKVPAMADAAELAAELHRYPDIEFSALVASPNGAKRAIAAGLRAIEYVVAASDSFSAANVGRSSAEATSQIGEILAIARGSGVIVEVIVATAWDCPFDGPTPSQRVLDIAAVARGLGVDRFSIADTIGTATPGRVSSLIAQLHPVIGDIALGGHFHNTRGAGLASAYAAVCSGVTRLDASVGGLGGCPFAPGATGNIATEDLVYLLADSGFEVHIDLPAAIAAAEVAKSVVGHDLPGALLRAGDRIRN
>NC_022663.1|WP_023371924.1|4898006_4899215_-|CoA-transferase
MTAPTGPLDGIRVLELGTLIAGPFAGRLLGDMGADVIKVEPPGAPDPLRTWGQAELNGHHVFWTVHARNKRAVTLDLRRPRGRELFLELVEKSDIAVENFRPGTLEKWNLGYDVLSERNPGIILVRVSGYGQTGPDAHKAGYASVAEAASGLRHLNGFPGGPPPRLALSLGDTLAGMFGAQGALAALYRRGVTGRGQVVDVALTESCLAVQESTIPDYDVGGVVRGPSGTRLEGIAPSNIYRSADGSWVVIAANQDTVFARLCKAMGRPELVTDERFATHGARGRNQDELDAIIGAWAAERRPGEIIETLSAAGVIAGPINTVAEVVDDPQLRARGMLVEHYDERVERSVLGPGIVPVLSESPGRVRSAGPPHPGRHNDDVYIGLLGKTVEELTDLRAEGVL
>NC_022663.1|WP_023371925.1|4899211_4900393_-|alpha/beta-fold-hydrolase
MTTRHDYQRIPYLVAFQNNSGVRDVYGGLAEITVLESYLLRPSDKPSDTALVFMHPIGGGAYLPMINALARAGHHVIYCNSRFRGTDSGLLMEKVVEDLGECIKDAKARLGYQKVVLAGWSGGGSLSMFYQQQAQHATVTSSPSGDGPDLTRLDLPAADGIMLLAAHISRHGTLTEWLDASILDETDPTKRDPELDLYHPDNPNQPPYSQEFLARYRQAQIDRNRRITAWVKDKLAELAARGRPDDEFCFVVHGTMADPRWLDPTVDPNERTPGTCYLGDPRVVNMSPVGLARFCSLRSWLSQWSYDDARGDGVACARDLAVPALVIGNLADDACTPSHTRRLFDAIGNSDKEMYEIPGATHYYAGPNQRDKLAHAVDVVTDWLIRHDFASTR
>NC_022663.1|WP_023371926.1|4900394_4901498_-|homogentisate-1,2-dioxygenase
MESFVHLRKGRTPRRLHADLDGLKDDELGRGGFTGRTANIYRRHDPTAYRAVGPLRPLDVLSDDLKPSDATDANGGPLLMFHNIDCRILLSRRHQAMPFYTRHVDGDLLCFVHRGSGMAETEFGPLRYREGDWVYIPKACTWRQIPDSETTLLMVEAADEFRVPAPGALGRHFPFDPSQITIPEPAPIDDDDRDQYEVRLIHRPLAEGVPTSLYYQHNPIDVEGWRGDNFPFTFNIGDYNVVTSNSVHLPPTVHLFMQATGVYVMNFLPKPAEGIPGTERTPWYHRNVDYDEIAFFHGGSLYGIPMPPGLISHAPQGVHHGAPEKARQRARRKFDEYSTVDWQVIAIDTRRRLTPCAEMLAHDLGQH
>NC_022663.1|WP_023371927.1|4901850_4903776_+|PPE-family-protein
MEFLTLPPEVNSARILRGPGPAPLRAAATAWATLSEDLASSATAVSSVMSEISGSAWQGPAAAAMAAAVAPYPGWLGAAATRAAAAGRHAATAAAAYETARTATVPLEMLAQNRSRLVSLVAADVLGLNAPAIAATEAHYEQLWAQDVGAMAGYYAGASAAVAQLTPWQTLLSTLESPVGGMKAAEAAVSASSPSASTAATGVTLVIGGSGYPIPSQSYVNTVVADYVTPTFPGFTTANAQSLYTPAQSYWITGVKTLTEDASWAQGLTILDNAIHAQLATGNNVAVQGFSQGAGIASLEMANLKAEGVPTSSVSFSLIGDPMNPNGGLYSRFDGLTLASMGKSFPGSTPANDYPTVIYTIEYDGFADFPQYPLNLVADANAMLGALYVHPQYPVLTPAQVVTAVQLPTQGPTTTTYYMIPTQNLPLLEPLRALPLGNTVADLIQPDLKVIVNLGYGNPDYGYSTGPANVPTPFGLFPDASPGVVVADLIDGTRQGIGAAAADLGTWHAPAGNPAPNPFALSDLTPPTVAATTIDGIIQGLQTGNTNLTNAVTSATSSAYATLLPTADMLSAILVSLPSYDVNLFLDGVRQALDGDPAGIINAIGYPIAADTGLLTFLSFFLAYAYYGAAKSIAGDFASLI
>NC_022663.1|WP_023371928.1|4903785_4904757_-|NADPH:quinone-oxidoreductase-family-protein
MRAIRVTRLEGPGAVEISEIDEPAGEGVVVDVYAAGAAFPDALLTRGLYQYRPEPPFVLGAEIAGVVRSAPQDAHVCAGDRVVGLTMLTGGMAEVAVLSPDRVFKLPDNVSFEAGAGLLFNDLTVYFALRVRGRLQRGETVLVHGAAGGIGTSALRLAPVLGASRTIAVVSTEEKAAIATAAGATDVVLAEGFKDAVKALTDGRGVDVVVDPVGGDRFTDSLRSLAPAGRLLVIGFTGGEIPTVKVNRLLLNNIDVVGVGWGAWAGKHPGALSEQWAALEQLLSSGELPPPEPVVYPLEQAAAAVASLENRTAKGKVVLRVRD

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Crispr_ID: NC_022663_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022663_15

4892392-4892582

Orphan

Consensus_repeat	Method
CAATGTTGCCACGGCGGCGACGGTGGTTGGTGATGCCAATA	PILER-CR

2 spacers

The CRISPR arrays of NC_022663_15

>merge|NC_022663|15|4892392-4892582|PILER-CR
CAATATTGCGACGGCGGCGACGGTGGTGGGTAATGACAATGTGATTGATGCGGCGAGTGCGATCGCGGTGGGGGAGACCAATGTTGGTACGGCGGCGACGGTGGTTGGTGATGCCAATAGTGGGGTGGCGGCTAGTGCGGATGGTCGTATCAATGTGGCCACGGCGGCGACGGTGGTTGGTGATGCCAATA

>NC_022663|15|2|4892392-4892582|PILER-CR
CAATATTGCGACGGCGGCGACGGTGGTGGGTAATGACAATG	TGATTGATGCGGCGAGTGCGATCGCGGTGGGGGAGAC
CAATGTTGGTACGGCGGCGACGGTGGTTGGTGATGCCAATA	GTGGGGTGGCGGCTAGTGCGGATGGTCGTAT
CAATGTGGCCACGGCGGCGACGGTGGTTGGTGATGCCAATA

Protein	Signature genes	Signature genes Name	Protein_function
NC_022663.1\|WP_023371914.1\|4882734_4883268_-\|YceI-family-protein	unknown	unknown	gnl\|CDD\|377274
NC_022663.1\|WP_023371924.1\|4898006_4899215_-\|CoA-transferase	unknown	unknown	gnl\|CDD\|367110
NC_022663.1\|WP_023371927.1\|4901850_4903776_+\|PPE-family-protein	unknown	unknown	gnl\|CDD\|369775
NC_022663.1\|WP_023371921.1\|4895243_4896482_-\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173838
NC_022663.1\|WP_023371925.1\|4899211_4900393_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|366166
NC_022663.1\|WP_023371907.1\|4877071_4877791_-\|NADH-quinone-oxidoreductase-subunit-C	unknown	unknown	gnl\|CDD\|181115
NC_022663.1\|WP_023371911.1\|4879554_4880250_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|226472
NC_022663.1\|WP_023371908.1\|4877787_4878342_-\|NADH-quinone-oxidoreductase-subunit-B	unknown	unknown	gnl\|CDD\|235797
NC_022663.1\|WP_023371920.1\|4894281_4895247_-\|phosphotransferase-family-protein	unknown	unknown	gnl\|CDD\|270703
NC_022663.1\|WP_023371926.1\|4900394_4901498_-\|homogentisate-1,2-dioxygenase	unknown	unknown	gnl\|CDD\|226039
NC_022663.1\|WP_023371919.1\|4893946_4894285_-\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_023371923.1\|4897113_4898010_-\|hydroxymethylglutaryl-CoA-lyase	unknown	unknown	gnl\|CDD\|163676
NC_022663.1\|WP_023371913.1\|4881456_4882719_+\|PPE-family-protein	unknown	unknown	gnl\|CDD\|366325
NC_022663.1\|WP_023371922.1\|4896493_4897114_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_022663.1\|WP_023371912.1\|4880246_4880870_-\|DedA-family-protein	unknown	unknown	gnl\|CDD\|223659
NC_022663.1\|WP_023371910.1\|4879023_4879425_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_022663.1\|WP_036391794.1\|4883392_4883794_-\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|378915
NC_022663.1\|WP_036444274.1\|4884236_4886216_+\|PPE-domain-containing-protein	unknown	unknown	gnl\|CDD\|366325
NC_022663.1\|WP_023371928.1\|4903785_4904757_-\|NADPH:quinone-oxidoreductase-family-protein	unknown	unknown	gnl\|CDD\|176203
NC_022663.1\|WP_023371909.1\|4878390_4878768_-\|NADH-quinone-oxidoreductase-subunit-A	unknown	unknown	gnl\|CDD\|181171

Protein	Function_ID	Function_description	E-value
NC_022663.1\|WP_023371914.1\|4882734_4883268_-\|YceI-family-protein	gnl\|CDD\|377274	pfam04264, YceI, YceI-like domain. E. coli YceI is a base-induced periplasmic protein. The recent structure of a member of this family shows that it binds to poly-isoprenoid. The structure consists of an extended, eight-stranded, antiparallel beta-barrel that resembles the lipocalin fold.	7.14033e-36
NC_022663.1\|WP_023371924.1\|4898006_4899215_-\|CoA-transferase	gnl\|CDD\|367110	pfam02515, CoA_transf_3, CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	4.63897e-152
NC_022663.1\|WP_023371927.1\|4901850_4903776_+\|PPE-family-protein	gnl\|CDD\|369775	pfam08237, PE-PPE, PE-PPE domain. This domain is found C terminal to the PE (pfam00934) and PPE (pfam00823) domains. The secondary structure of this domain is predicted to be a mixture of alpha helices and beta strands.	6.82461e-82
NC_022663.1\|WP_023371921.1\|4895243_4896482_-\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173838	cd00567, ACAD, Acyl-CoA dehydrogenase. Both mitochondrial acyl-CoA dehydrogenases (ACAD) and peroxisomal acyl-CoA oxidases (AXO) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. In contrast, AXO catalyzes a different oxidative half-reaction, in which the reduced FAD is reoxidized by molecular oxygen. The ACAD family includes the eukaryotic beta-oxidation enzymes, short (SCAD), medium (MCAD), long (LCAD) and very-long (VLCAD) chain acyl-CoA dehydrogenases. These enzymes all share high sequence similarity, but differ in their substrate specificities. The ACAD family also includes amino acid catabolism enzymes such as Isovaleryl-CoA dehydrogenase (IVD), short/branched chain acyl-CoA dehydrogenases(SBCAD), Isobutyryl-CoA dehydrogenase (IBDH), glutaryl-CoA deydrogenase (GCD) and Crotonobetainyl-CoA dehydrogenase. The mitochondrial ACAD's are generally homotetramers, except for VLCAD, which is a homodimer. Related enzymes include the SOS adaptive reponse proten aidB, Naphthocyclinone hydroxylase (NcnH), and and Dibenzothiophene (DBT) desulfurization enzyme C (DszC).	3.94776e-102
NC_022663.1\|WP_023371925.1\|4899211_4900393_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	9.24652e-07
NC_022663.1\|WP_023371907.1\|4877071_4877791_-\|NADH-quinone-oxidoreductase-subunit-C	gnl\|CDD\|181115	PRK07785, PRK07785, NADH dehydrogenase subunit C; Provisional.	1.25775e-155
NC_022663.1\|WP_023371911.1\|4879554_4880250_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|226472	COG3963, COG3963, Phospholipid N-methyltransferase [Lipid metabolism].	3.12188e-20
NC_022663.1\|WP_023371908.1\|4877787_4878342_-\|NADH-quinone-oxidoreductase-subunit-B	gnl\|CDD\|235797	PRK06411, PRK06411, NADH-quinone oxidoreductase subunit NuoB.	7.87269e-101
NC_022663.1\|WP_023371920.1\|4894281_4895247_-\|phosphotransferase-family-protein	gnl\|CDD\|270703	cd05154, ACAD10_11_N-like, N-terminal domain of Acyl-CoA dehydrogenase (ACAD) 10 and 11, and similar proteins. This subfamily is composed of the N-terminal domains of vertebrate ACAD10 and ACAD11, and similar uncharacterized bacterial and eukaryotic proteins. ACADs are a family of flavoproteins that are involved in the beta-oxidation of fatty acyl-CoA derivatives. ACAD deficiency can cause metabolic disorders including muscle fatigue, hypoglycemia, and hepatic lipidosis. There are at least 11 distinct ACADs, some of which show distinct substrate specificities to either straight-chain or branched-chain fatty acids. ACAD10 is widely expressed in human tissues and highly expressed in liver, kidney, pancreas, and spleen. ACAD10 and ACAD11 are both significantly expressed in human brain tissues. They contain a long N-terminal domain with similarity to phosphotransferases with a Protein Kinase fold, which is absent in other ACADs. They may exhibit multiple functions in acyl-CoA oxidation pathways. ACAD11 utilizes substrates with carbon chain lengths of 20 to 26, with optimal activity towards C22CoA. ACAD10 may be associated with an increased risk in type II diabetes. The ACAD10/11-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).	1.07571e-64
NC_022663.1\|WP_023371926.1\|4900394_4901498_-\|homogentisate-1,2-dioxygenase	gnl\|CDD\|226039	COG3508, HmgA, Homogentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism].	4.64335e-27
NC_022663.1\|WP_023371923.1\|4897113_4898010_-\|hydroxymethylglutaryl-CoA-lyase	gnl\|CDD\|163676	cd07938, DRE_TIM_HMGL, 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain. 3-hydroxy-3-methylglutaryl-CoA lyase (HMGL) catalyzes the cleavage of HMG-CoA to acetyl-CoA and acetoacetate, one of the terminal steps in ketone body generation and leucine degradation, and is a key enzyme in the pathway that supplies metabolic fuel to extrahepatic tissues. Mutations in HMGL cause a human autosomal recessive disorder called primary metabolic aciduria that affects ketogenesis and leucine catabolism and can be fatal due to an inability to tolerate hypoglycemia. HMGL has a TIM barrel domain with a catalytic center containing a divalent cation-binding site formed by a cluster of invariant residues that cap the core of the barrel. The cleavage of HMG-CoA requires the presence of a divalent cation like Mg2+ or Mn2+, and the reaction is thought to involve general acid/base catalysis. This family belongs to the DRE-TIM metallolyase superfamily. DRE-TIM metallolyases include 2-isopropylmalate synthase (IPMS), alpha-isopropylmalate synthase (LeuA), 3-hydroxy-3-methylglutaryl-CoA lyase, homocitrate synthase, citramalate synthase, 4-hydroxy-2-oxovalerate aldolase, re-citrate synthase, transcarboxylase 5S, pyruvate carboxylase, AksA, and FrbC. These members all share a conserved triose-phosphate isomerase (TIM) barrel domain consisting of a core beta(8)-alpha(8) motif with the eight parallel beta strands forming an enclosed barrel surrounded by eight alpha helices. The domain has a catalytic center containing a divalent cation-binding site formed by a cluster of invariant residues that cap the core of the barrel. In addition, the catalytic site includes three invariant residues - an aspartate (D), an arginine (R), and a glutamate (E) - which is the basis for the domain name "DRE-TIM".	1.49947e-120
NC_022663.1\|WP_023371913.1\|4881456_4882719_+\|PPE-family-protein	gnl\|CDD\|366325	pfam00823, PPE, PPE family. This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	1.0117e-49
NC_022663.1\|WP_023371922.1\|4896493_4897114_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.3356e-15
NC_022663.1\|WP_023371912.1\|4880246_4880870_-\|DedA-family-protein	gnl\|CDD\|223659	COG0586, DedA, Uncharacterized membrane-associated protein [Function unknown].	7.48874e-27
NC_022663.1\|WP_023371910.1\|4879023_4879425_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	0.00136066
NC_022663.1\|WP_036391794.1\|4883392_4883794_-\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|378915	pfam12680, SnoaL_2, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	0.000216441
NC_022663.1\|WP_036444274.1\|4884236_4886216_+\|PPE-domain-containing-protein	gnl\|CDD\|366325	pfam00823, PPE, PPE family. This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	6.45138e-74
NC_022663.1\|WP_023371928.1\|4903785_4904757_-\|NADPH:quinone-oxidoreductase-family-protein	gnl\|CDD\|176203	cd08241, QOR1, Quinone oxidoreductase (QOR). QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR acts in the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site, and a structural zinc in a lobe of the catalytic domain. NAD(H)-binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	1.5887e-132
NC_022663.1\|WP_023371909.1\|4878390_4878768_-\|NADH-quinone-oxidoreductase-subunit-A	gnl\|CDD\|181171	PRK07928, PRK07928, NADH dehydrogenase subunit A; Validated.	7.35513e-73

>NC_022663.1|WP_036444274.1|4884236_4886216_+|PPE-domain-containing-protein
MNFSVLPPEINSVRIFAGAGPQPMLAAATAWDGLAGELAGAASSFSSVASGLVDGSWRGPASAAMAAAAAPYARWLSAAAGHASGAAAQARAVARAFDAARAATVHPLMVAINRNRFVQLVASNVLGLNAPAIASAEAQYEQMWAQDVVAMLGYHADTSAAAAALSPWGAGPQGNSAGSGQSGTSEMPASGRGPVASAISAGSSAAAGTNISLSNLGFGNTGNGNFGSGNAGDLNLGSGNNGNVNLGSGNNGNVNFGSGNTGNVNLGSGNAGSLNAGSGNAGNNNLGSGNNGDANLGHGNVGSNNFGSGNIGGGNLGFGNAGSNNFGSGNNGSGNLGSGNGGNLNVGFANTGNNNIGFANTGNNNIGIGLTGDNQIGFGGLNSGTGNVGLFNSGSGNTGIFNSGSNNLGWLNSGVGNWGGWNSGMGSTGFGNSGVTSTGFWNSGSYDTGFGNAGSGNAGAFNAGSHNTGWFNSGSGSTGDYNSGDGNFGSFNAGDVNTGSFNAGSVNTGLWNSGHTNTGALNSGTLNTGFGSSIIQTVANSGFGNTGTGNSGFNNFGDNNSGYGNAGVAGGPGQNNAGIGNQGTLHSGIGNTGSNNDSGFGNTGFYNVGFFNTGDNNSGFGNINDVASGFNSGIGNFGNSNSGGFNIGTGWAGFFGSNF
>NC_022663.1|WP_036391794.1|4883392_4883794_-|nuclear-transport-factor-2-family-protein
MPSSTTEAIAEVADRLFTAIENSDRAAVARMWSDDIAVWRAGAHRDDDKARALRVIDWFVSATAERRYEVLDRQIFEDGSGRGFVQQHVLHAAGQTGQSIELRVCIVIKLDTEGLINRIDEYFDPAELAPLLG
>NC_022663.1|WP_023371914.1|4882734_4883268_-|YceI-family-protein
MTTLETLLSDPDAAGAWNLVPDRSAVTFKVKNMWGLLAVKGEFTKFVGRGNLTDQGTVSGYLEVDVASLRTGIRLRDKHLLSADFFEVERFPEIRVVVTALHPTKGKHAELQASFTIKGITDPVTLPVTVTEFSDGSVRIAGETEIDRVQFGLRWNKFGILAVTATASGEVCFVKAP
>NC_022663.1|WP_023371913.1|4881456_4882719_+|PPE-family-protein
MSFWVLPPEINSLRMFIGAGSAPMLQAATAWAGLADELGAAAQSFASVTSGLAGQAWQGPAAAAMAAAAAPYAAWLSAAAAQSAGAAGQARAMVSMFEAAQAATVLPAAVAANRDAFVQLVMSNLFGQNAPAIAFAESIYEEMWAADVSAMSGYYSGAAALASQLVPWQSILKGLPGMGSAGAAGTSAGSGAAGTTNVGGNGEGANVAGGDNAGGASGGPVGGETTNVVNSSTSAGLAQADPMYSNVGQGTAGSGNVGSASLLSGGTTSASGGVATPGMMGVPIPIPATGGNQTGSAGIGVGAGSAGNAAPTRVPEAAAPPAAEVEAAAPQLRVLPNADPEIAAKAAPVPVARVTQSTGSGIPESALRPSRTADVSHRSANTQDQASEAEEKVVSLRPEAEKGKLRPRAKQEPGIQMRGG
>NC_022663.1|WP_023371912.1|4880246_4880870_-|DedA-family-protein
METFILSHHSYLLLPLLTATGIPVPEEVVTVAAGALSSPSVGRLEPGLAILACLAGVLVGDCALYWIGRGLGQTHLGRYHWFARLVDSDRTGHVERILQQHGVKVFLLVRFLLGMRTPLYLAIGALKMDFRRFLVCDVVCATLAVGIFFLLSYLGAGWISGLIHRSEWAATAILLVTAVTGGLYYGVWKRWRVQLSAHGPRLQGKAQ
>NC_022663.1|WP_023371911.1|4879554_4880250_-|methyltransferase-domain-containing-protein
MTQQSPDTTLFFREFCGKFETTGSVMPSTRYLARAMTRHLRRRGPAPIRVLDCGPGTGAFTDRIVDHLRPGDRLDVVEINDSFVRVLQRRFATEPRWQAASNFTNIHEVPFQYFDAAEPYDFIISSLPHSNFPAITVAEILHSYTRLLKPGGVLTYVEYLYLRQIRRTLSRGTQRARIRSVEQLMLSHMSEHEVAHENVLRNVPPARVHHLIAPADGTGGNTGRDWNTLSA
>NC_022663.1|WP_023371910.1|4879023_4879425_-|response-regulator-transcription-factor
MPDSSDALRILVYSNNVQTRQQVMRALGKRLHPDLPELTYVEIATAPMVIQRMDEGGIDLAILDGEATPAGGMGIAKQLKDELSTCPPILVLTGRPDDSWLASWSRAEAAVSHPIDPIVLGRTALGLLRAPAL
>NC_022663.1|WP_023371909.1|4878390_4878768_-|NADH-quinone-oxidoreductase-subunit-A
MNVYIPILVLAALAAAFAVFSVVIASLAGPSRFNRSKLAAYECGIEPTDSSVSSPHATAGQRFPIKYYLTAMLFIVFDIEIVFLYPWAVSFDALGTFALVEMLIFMLTVFVAYAYVWRRGGLTWD
>NC_022663.1|WP_023371908.1|4877787_4878342_-|NADH-quinone-oxidoreductase-subunit-B
MGLEEQLPGGILLSTVEKVAGYVRKNSLWPATFGLACCAIEMMATAGPRFDLARFGMERFSATPRQADLMIVAGRVSQKMAPVLRQIYDQMAEPKWVLAMGVCASSGGMFNNYAIVQGVDHVVPVDIYLPGCPPRPEMLLHAILKLHEKIQEMPLGVNRERAIAEAEEAALLARPTIEMRGLLR
>NC_022663.1|WP_023371907.1|4877071_4877791_-|NADH-quinone-oxidoreductase-subunit-C
MSSPDQDPREAIARADEEVIDVRRGMFGVSGTGDTSGYGRLVRQVTLPGSSPRPYGGYFDDIADRLAEALHGEGVEFDDAIEKVVVYPQGEGAELTLHVRRERLPQVAQRLRDEPELRFEMCLGVNGVHYPHETGRELHAVYPLQSITHNRRLRLEVSVPDSDPHIPSLYSVYPTNDWHERETYDFFGIVFDGHPSLTRIEMPDDWHGHPQRKDYPLGGIPVEYKGAQIPPPDERRGYN
>NC_022663.1|WP_023371919.1|4893946_4894285_-|hypothetical-protein
MTGLHGRPTAAELVAAVADFLEGDVRAATSGQVNFHARVAANALRMVERELLSSGDAEVRTALADLGFADEAALAAAIRAGELDGRDEEVMACLRALVRHRLAVAHPGYDSE
>NC_022663.1|WP_023371920.1|4894281_4895247_-|phosphotransferase-family-protein
MTLLEDLAALLDPLLGAEVAIENLRVLTGGASRTTWAFDAVVGAERRPLILRIGPPDDVHAGMELEARVQAAAAAAGAPVPHILLADDSPAALGNPFLICEEVKGETIVRRIQRQLDDPGRTRLLRQCARALAAIHRAEWNGLGLVREDPLGQWRDRLDSMGDTTATFEWAFRWLRARRPPPSTAVLVHGDFRMGNLIVDGSDLAAVLDWELVHVGEAYEDLAWFCVRAWRFGAPASLGAGGLGSIESLLQAYEEAGGATVDRAAFRWWLVLATLRWGVICRYQAERHLSGRTRSVELAAIGRRVCENEWDLLELLEAVGR
>NC_022663.1|WP_023371921.1|4895243_4896482_-|acyl-CoA-dehydrogenase-family-protein
MDFSLPEHLPGLLAEMDEFIESDIKPLERQHIQYFDHRREHARTDWDNGGVPRREWEDLLAEMRRRADQAGWLRYGLPSRFGGRDGTNVDMAVIREHLAHKGLGLHNDLQNESSIVGNFPQVIMMDRFGTEAQKKEWTEALITGERSMAFGLTEPSHGSDATWLETRAERDGNSWVINGAKRFNTGVHRATHDLVFARTSGEPGQARGITAFLVPTDTPGFTVPYYWWTLNMPTDHGEVALEDVRVSGDAVLGEVDRGLEVGQTFLHENRIRQAASSLGAAQYCIDRAVDYANERRVFGKPLSVNQAVQWPLVELQTEAQMVRLLVYYAADQLDRNHHMEVSDKVAMANYRANRLVCEAADRAMQVFGGMGYSRHEPFEHIYRHHRRYRITEGAEEIQIRRVAQRLFKFGKK
>NC_022663.1|WP_023371922.1|4896493_4897114_-|TetR/AcrR-family-transcriptional-regulator
MAAGVLTAKGRQTRQAIEQAARKLFAERGFHGTTLADITSAAGKSPAVFYRYFSDKEDLLAALAESFLHDVVAPSGLSVHLPDTPDDDTFFTSVVTGYWNIFKQNIGIMIAVAQLAATQRRFAAVQNEFRRFGMDIVAASVRRAQEQGYGAELHPQHTAAAIALLFENFTTVFVGRSGPENLRLDISDEDAIKTLSMIWKKTLYGT
>NC_022663.1|WP_023371923.1|4897113_4898010_-|hydroxymethylglutaryl-CoA-lyase
MNQHVTIREVSLRDGLQIEKPIPLAAKLELLAAIAATGVREVEATAFVSPSKVPAMADAAELAAELHRYPDIEFSALVASPNGAKRAIAAGLRAIEYVVAASDSFSAANVGRSSAEATSQIGEILAIARGSGVIVEVIVATAWDCPFDGPTPSQRVLDIAAVARGLGVDRFSIADTIGTATPGRVSSLIAQLHPVIGDIALGGHFHNTRGAGLASAYAAVCSGVTRLDASVGGLGGCPFAPGATGNIATEDLVYLLADSGFEVHIDLPAAIAAAEVAKSVVGHDLPGALLRAGDRIRN
>NC_022663.1|WP_023371924.1|4898006_4899215_-|CoA-transferase
MTAPTGPLDGIRVLELGTLIAGPFAGRLLGDMGADVIKVEPPGAPDPLRTWGQAELNGHHVFWTVHARNKRAVTLDLRRPRGRELFLELVEKSDIAVENFRPGTLEKWNLGYDVLSERNPGIILVRVSGYGQTGPDAHKAGYASVAEAASGLRHLNGFPGGPPPRLALSLGDTLAGMFGAQGALAALYRRGVTGRGQVVDVALTESCLAVQESTIPDYDVGGVVRGPSGTRLEGIAPSNIYRSADGSWVVIAANQDTVFARLCKAMGRPELVTDERFATHGARGRNQDELDAIIGAWAAERRPGEIIETLSAAGVIAGPINTVAEVVDDPQLRARGMLVEHYDERVERSVLGPGIVPVLSESPGRVRSAGPPHPGRHNDDVYIGLLGKTVEELTDLRAEGVL
>NC_022663.1|WP_023371925.1|4899211_4900393_-|alpha/beta-fold-hydrolase
MTTRHDYQRIPYLVAFQNNSGVRDVYGGLAEITVLESYLLRPSDKPSDTALVFMHPIGGGAYLPMINALARAGHHVIYCNSRFRGTDSGLLMEKVVEDLGECIKDAKARLGYQKVVLAGWSGGGSLSMFYQQQAQHATVTSSPSGDGPDLTRLDLPAADGIMLLAAHISRHGTLTEWLDASILDETDPTKRDPELDLYHPDNPNQPPYSQEFLARYRQAQIDRNRRITAWVKDKLAELAARGRPDDEFCFVVHGTMADPRWLDPTVDPNERTPGTCYLGDPRVVNMSPVGLARFCSLRSWLSQWSYDDARGDGVACARDLAVPALVIGNLADDACTPSHTRRLFDAIGNSDKEMYEIPGATHYYAGPNQRDKLAHAVDVVTDWLIRHDFASTR
>NC_022663.1|WP_023371926.1|4900394_4901498_-|homogentisate-1,2-dioxygenase
MESFVHLRKGRTPRRLHADLDGLKDDELGRGGFTGRTANIYRRHDPTAYRAVGPLRPLDVLSDDLKPSDATDANGGPLLMFHNIDCRILLSRRHQAMPFYTRHVDGDLLCFVHRGSGMAETEFGPLRYREGDWVYIPKACTWRQIPDSETTLLMVEAADEFRVPAPGALGRHFPFDPSQITIPEPAPIDDDDRDQYEVRLIHRPLAEGVPTSLYYQHNPIDVEGWRGDNFPFTFNIGDYNVVTSNSVHLPPTVHLFMQATGVYVMNFLPKPAEGIPGTERTPWYHRNVDYDEIAFFHGGSLYGIPMPPGLISHAPQGVHHGAPEKARQRARRKFDEYSTVDWQVIAIDTRRRLTPCAEMLAHDLGQH
>NC_022663.1|WP_023371927.1|4901850_4903776_+|PPE-family-protein
MEFLTLPPEVNSARILRGPGPAPLRAAATAWATLSEDLASSATAVSSVMSEISGSAWQGPAAAAMAAAVAPYPGWLGAAATRAAAAGRHAATAAAAYETARTATVPLEMLAQNRSRLVSLVAADVLGLNAPAIAATEAHYEQLWAQDVGAMAGYYAGASAAVAQLTPWQTLLSTLESPVGGMKAAEAAVSASSPSASTAATGVTLVIGGSGYPIPSQSYVNTVVADYVTPTFPGFTTANAQSLYTPAQSYWITGVKTLTEDASWAQGLTILDNAIHAQLATGNNVAVQGFSQGAGIASLEMANLKAEGVPTSSVSFSLIGDPMNPNGGLYSRFDGLTLASMGKSFPGSTPANDYPTVIYTIEYDGFADFPQYPLNLVADANAMLGALYVHPQYPVLTPAQVVTAVQLPTQGPTTTTYYMIPTQNLPLLEPLRALPLGNTVADLIQPDLKVIVNLGYGNPDYGYSTGPANVPTPFGLFPDASPGVVVADLIDGTRQGIGAAAADLGTWHAPAGNPAPNPFALSDLTPPTVAATTIDGIIQGLQTGNTNLTNAVTSATSSAYATLLPTADMLSAILVSLPSYDVNLFLDGVRQALDGDPAGIINAIGYPIAADTGLLTFLSFFLAYAYYGAAKSIAGDFASLI
>NC_022663.1|WP_023371928.1|4903785_4904757_-|NADPH:quinone-oxidoreductase-family-protein
MRAIRVTRLEGPGAVEISEIDEPAGEGVVVDVYAAGAAFPDALLTRGLYQYRPEPPFVLGAEIAGVVRSAPQDAHVCAGDRVVGLTMLTGGMAEVAVLSPDRVFKLPDNVSFEAGAGLLFNDLTVYFALRVRGRLQRGETVLVHGAAGGIGTSALRLAPVLGASRTIAVVSTEEKAAIATAAGATDVVLAEGFKDAVKALTDGRGVDVVVDPVGGDRFTDSLRSLAPAGRLLVIGFTGGEIPTVKVNRLLLNNIDVVGVGWGAWAGKHPGALSEQWAALEQLLSSGELPPPEPVVYPLEQAAAAVASLENRTAKGKVVLRVRD

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Crispr_ID: NC_022663_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022663_14

4891374-4891836

Orphan

Consensus_repeat	Method
TNGCGACGGCGGCGACGGTGGTNGG	CRT

6 spacers

The CRISPR arrays of NC_022663_14

>merge|NC_022663|14|4891374-4891836|CRT
TTGCGACGGCGGCGACGGTGGTGGGCAACGCCAACAATGGGGTGGCGGCCGGTGCGGATGGCAGCCTCAACATCGCGTCGGCGGCGACGGTGGTGGGTGCCGACAATGGTGGGGTTGTGGCGGGGTCGAGCGGTGACACGAACATTGCGACGGCGGCGACGGTGGTGGGGGATCGTAATGCTGGGGTGTTGGCCAGTGCGCAGGGGGTGCGCAATATTGCGACGGCGGCGACGGTGGTGGGTAATGACAATGTGATTGATGTGGCCAGTGCGATCGCGGTGGGGGAGACCAATGTTGGTACGGCGGCGACGGTGGTTGGTGATGCCAATAGTGGGGTGGCGGCTAGTGCGGATGGTCGTATCAATGTGGCCACGGCGGCCACGGCGGTCGGTGATGGCAATAGTGGAGTTACGGCGGATGCGGATGGCAGTGTCAATGTGGTGACGGCGGCGACCGCGGTTTT

>NC_022663|14|2|4891374-4891836|CRT
TTGCGACGGCGGCGACGGTGGTGGG	CAACGCCAACAATGGGGTGGCGGCCGGTGCGGATGGCAGCCTCAACA
TCGCGTCGGCGGCGACGGTGGTGGG	TGCCGACAATGGTGGGGTTGTGGCGGGGTCGAGCGGTGACACGAACA
TTGCGACGGCGGCGACGGTGGTGGG	GGATCGTAATGCTGGGGTGTTGGCCAGTGCGCAGGGGGTGCGCAATA
TTGCGACGGCGGCGACGGTGGTGGG	TAATGACAATGTGATTGATGTGGCCAGTGCGATCGCGGTGGGGGAGACCAATG
TTGGTACGGCGGCGACGGTGGTTGG	TGATGCCAATAGTGGGGTGGCGGCTAGTGCGGATGGTCGTATCAATG
TGGCCACGGCGGCCACGGCGGTCGG	TGATGGCAATAGTGGAGTTACGGCGGATGCGGATGGCAGTGTCAATG
TGGTGACGGCGGCGACCGCGGTTTT

Protein	Signature genes	Signature genes Name	Protein_function
NC_022663.1\|WP_023371914.1\|4882734_4883268_-\|YceI-family-protein	unknown	unknown	gnl\|CDD\|377274
NC_022663.1\|WP_023371924.1\|4898006_4899215_-\|CoA-transferase	unknown	unknown	gnl\|CDD\|367110
NC_022663.1\|WP_023371927.1\|4901850_4903776_+\|PPE-family-protein	unknown	unknown	gnl\|CDD\|369775
NC_022663.1\|WP_023371921.1\|4895243_4896482_-\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173838
NC_022663.1\|WP_023371925.1\|4899211_4900393_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|366166
NC_022663.1\|WP_023371907.1\|4877071_4877791_-\|NADH-quinone-oxidoreductase-subunit-C	unknown	unknown	gnl\|CDD\|181115
NC_022663.1\|WP_023371911.1\|4879554_4880250_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|226472
NC_022663.1\|WP_023371908.1\|4877787_4878342_-\|NADH-quinone-oxidoreductase-subunit-B	unknown	unknown	gnl\|CDD\|235797
NC_022663.1\|WP_023371920.1\|4894281_4895247_-\|phosphotransferase-family-protein	unknown	unknown	gnl\|CDD\|270703
NC_022663.1\|WP_023371926.1\|4900394_4901498_-\|homogentisate-1,2-dioxygenase	unknown	unknown	gnl\|CDD\|226039
NC_022663.1\|WP_023371919.1\|4893946_4894285_-\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_023371923.1\|4897113_4898010_-\|hydroxymethylglutaryl-CoA-lyase	unknown	unknown	gnl\|CDD\|163676
NC_022663.1\|WP_023371913.1\|4881456_4882719_+\|PPE-family-protein	unknown	unknown	gnl\|CDD\|366325
NC_022663.1\|WP_023371922.1\|4896493_4897114_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_022663.1\|WP_023371912.1\|4880246_4880870_-\|DedA-family-protein	unknown	unknown	gnl\|CDD\|223659
NC_022663.1\|WP_023371910.1\|4879023_4879425_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_022663.1\|WP_036391794.1\|4883392_4883794_-\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|378915
NC_022663.1\|WP_036444274.1\|4884236_4886216_+\|PPE-domain-containing-protein	unknown	unknown	gnl\|CDD\|366325
NC_022663.1\|WP_023371928.1\|4903785_4904757_-\|NADPH:quinone-oxidoreductase-family-protein	unknown	unknown	gnl\|CDD\|176203
NC_022663.1\|WP_023371909.1\|4878390_4878768_-\|NADH-quinone-oxidoreductase-subunit-A	unknown	unknown	gnl\|CDD\|181171

Protein	Function_ID	Function_description	E-value
NC_022663.1\|WP_023371914.1\|4882734_4883268_-\|YceI-family-protein	gnl\|CDD\|377274	pfam04264, YceI, YceI-like domain. E. coli YceI is a base-induced periplasmic protein. The recent structure of a member of this family shows that it binds to poly-isoprenoid. The structure consists of an extended, eight-stranded, antiparallel beta-barrel that resembles the lipocalin fold.	7.14033e-36
NC_022663.1\|WP_023371924.1\|4898006_4899215_-\|CoA-transferase	gnl\|CDD\|367110	pfam02515, CoA_transf_3, CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	4.63897e-152
NC_022663.1\|WP_023371927.1\|4901850_4903776_+\|PPE-family-protein	gnl\|CDD\|369775	pfam08237, PE-PPE, PE-PPE domain. This domain is found C terminal to the PE (pfam00934) and PPE (pfam00823) domains. The secondary structure of this domain is predicted to be a mixture of alpha helices and beta strands.	6.82461e-82
NC_022663.1\|WP_023371921.1\|4895243_4896482_-\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173838	cd00567, ACAD, Acyl-CoA dehydrogenase. Both mitochondrial acyl-CoA dehydrogenases (ACAD) and peroxisomal acyl-CoA oxidases (AXO) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. In contrast, AXO catalyzes a different oxidative half-reaction, in which the reduced FAD is reoxidized by molecular oxygen. The ACAD family includes the eukaryotic beta-oxidation enzymes, short (SCAD), medium (MCAD), long (LCAD) and very-long (VLCAD) chain acyl-CoA dehydrogenases. These enzymes all share high sequence similarity, but differ in their substrate specificities. The ACAD family also includes amino acid catabolism enzymes such as Isovaleryl-CoA dehydrogenase (IVD), short/branched chain acyl-CoA dehydrogenases(SBCAD), Isobutyryl-CoA dehydrogenase (IBDH), glutaryl-CoA deydrogenase (GCD) and Crotonobetainyl-CoA dehydrogenase. The mitochondrial ACAD's are generally homotetramers, except for VLCAD, which is a homodimer. Related enzymes include the SOS adaptive reponse proten aidB, Naphthocyclinone hydroxylase (NcnH), and and Dibenzothiophene (DBT) desulfurization enzyme C (DszC).	3.94776e-102
NC_022663.1\|WP_023371925.1\|4899211_4900393_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	9.24652e-07
NC_022663.1\|WP_023371907.1\|4877071_4877791_-\|NADH-quinone-oxidoreductase-subunit-C	gnl\|CDD\|181115	PRK07785, PRK07785, NADH dehydrogenase subunit C; Provisional.	1.25775e-155
NC_022663.1\|WP_023371911.1\|4879554_4880250_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|226472	COG3963, COG3963, Phospholipid N-methyltransferase [Lipid metabolism].	3.12188e-20
NC_022663.1\|WP_023371908.1\|4877787_4878342_-\|NADH-quinone-oxidoreductase-subunit-B	gnl\|CDD\|235797	PRK06411, PRK06411, NADH-quinone oxidoreductase subunit NuoB.	7.87269e-101
NC_022663.1\|WP_023371920.1\|4894281_4895247_-\|phosphotransferase-family-protein	gnl\|CDD\|270703	cd05154, ACAD10_11_N-like, N-terminal domain of Acyl-CoA dehydrogenase (ACAD) 10 and 11, and similar proteins. This subfamily is composed of the N-terminal domains of vertebrate ACAD10 and ACAD11, and similar uncharacterized bacterial and eukaryotic proteins. ACADs are a family of flavoproteins that are involved in the beta-oxidation of fatty acyl-CoA derivatives. ACAD deficiency can cause metabolic disorders including muscle fatigue, hypoglycemia, and hepatic lipidosis. There are at least 11 distinct ACADs, some of which show distinct substrate specificities to either straight-chain or branched-chain fatty acids. ACAD10 is widely expressed in human tissues and highly expressed in liver, kidney, pancreas, and spleen. ACAD10 and ACAD11 are both significantly expressed in human brain tissues. They contain a long N-terminal domain with similarity to phosphotransferases with a Protein Kinase fold, which is absent in other ACADs. They may exhibit multiple functions in acyl-CoA oxidation pathways. ACAD11 utilizes substrates with carbon chain lengths of 20 to 26, with optimal activity towards C22CoA. ACAD10 may be associated with an increased risk in type II diabetes. The ACAD10/11-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).	1.07571e-64
NC_022663.1\|WP_023371926.1\|4900394_4901498_-\|homogentisate-1,2-dioxygenase	gnl\|CDD\|226039	COG3508, HmgA, Homogentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism].	4.64335e-27
NC_022663.1\|WP_023371923.1\|4897113_4898010_-\|hydroxymethylglutaryl-CoA-lyase	gnl\|CDD\|163676	cd07938, DRE_TIM_HMGL, 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain. 3-hydroxy-3-methylglutaryl-CoA lyase (HMGL) catalyzes the cleavage of HMG-CoA to acetyl-CoA and acetoacetate, one of the terminal steps in ketone body generation and leucine degradation, and is a key enzyme in the pathway that supplies metabolic fuel to extrahepatic tissues. Mutations in HMGL cause a human autosomal recessive disorder called primary metabolic aciduria that affects ketogenesis and leucine catabolism and can be fatal due to an inability to tolerate hypoglycemia. HMGL has a TIM barrel domain with a catalytic center containing a divalent cation-binding site formed by a cluster of invariant residues that cap the core of the barrel. The cleavage of HMG-CoA requires the presence of a divalent cation like Mg2+ or Mn2+, and the reaction is thought to involve general acid/base catalysis. This family belongs to the DRE-TIM metallolyase superfamily. DRE-TIM metallolyases include 2-isopropylmalate synthase (IPMS), alpha-isopropylmalate synthase (LeuA), 3-hydroxy-3-methylglutaryl-CoA lyase, homocitrate synthase, citramalate synthase, 4-hydroxy-2-oxovalerate aldolase, re-citrate synthase, transcarboxylase 5S, pyruvate carboxylase, AksA, and FrbC. These members all share a conserved triose-phosphate isomerase (TIM) barrel domain consisting of a core beta(8)-alpha(8) motif with the eight parallel beta strands forming an enclosed barrel surrounded by eight alpha helices. The domain has a catalytic center containing a divalent cation-binding site formed by a cluster of invariant residues that cap the core of the barrel. In addition, the catalytic site includes three invariant residues - an aspartate (D), an arginine (R), and a glutamate (E) - which is the basis for the domain name "DRE-TIM".	1.49947e-120
NC_022663.1\|WP_023371913.1\|4881456_4882719_+\|PPE-family-protein	gnl\|CDD\|366325	pfam00823, PPE, PPE family. This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	1.0117e-49
NC_022663.1\|WP_023371922.1\|4896493_4897114_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.3356e-15
NC_022663.1\|WP_023371912.1\|4880246_4880870_-\|DedA-family-protein	gnl\|CDD\|223659	COG0586, DedA, Uncharacterized membrane-associated protein [Function unknown].	7.48874e-27
NC_022663.1\|WP_023371910.1\|4879023_4879425_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	0.00136066
NC_022663.1\|WP_036391794.1\|4883392_4883794_-\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|378915	pfam12680, SnoaL_2, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	0.000216441
NC_022663.1\|WP_036444274.1\|4884236_4886216_+\|PPE-domain-containing-protein	gnl\|CDD\|366325	pfam00823, PPE, PPE family. This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	6.45138e-74
NC_022663.1\|WP_023371928.1\|4903785_4904757_-\|NADPH:quinone-oxidoreductase-family-protein	gnl\|CDD\|176203	cd08241, QOR1, Quinone oxidoreductase (QOR). QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR acts in the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site, and a structural zinc in a lobe of the catalytic domain. NAD(H)-binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	1.5887e-132
NC_022663.1\|WP_023371909.1\|4878390_4878768_-\|NADH-quinone-oxidoreductase-subunit-A	gnl\|CDD\|181171	PRK07928, PRK07928, NADH dehydrogenase subunit A; Validated.	7.35513e-73

>NC_022663.1|WP_036444274.1|4884236_4886216_+|PPE-domain-containing-protein
MNFSVLPPEINSVRIFAGAGPQPMLAAATAWDGLAGELAGAASSFSSVASGLVDGSWRGPASAAMAAAAAPYARWLSAAAGHASGAAAQARAVARAFDAARAATVHPLMVAINRNRFVQLVASNVLGLNAPAIASAEAQYEQMWAQDVVAMLGYHADTSAAAAALSPWGAGPQGNSAGSGQSGTSEMPASGRGPVASAISAGSSAAAGTNISLSNLGFGNTGNGNFGSGNAGDLNLGSGNNGNVNLGSGNNGNVNFGSGNTGNVNLGSGNAGSLNAGSGNAGNNNLGSGNNGDANLGHGNVGSNNFGSGNIGGGNLGFGNAGSNNFGSGNNGSGNLGSGNGGNLNVGFANTGNNNIGFANTGNNNIGIGLTGDNQIGFGGLNSGTGNVGLFNSGSGNTGIFNSGSNNLGWLNSGVGNWGGWNSGMGSTGFGNSGVTSTGFWNSGSYDTGFGNAGSGNAGAFNAGSHNTGWFNSGSGSTGDYNSGDGNFGSFNAGDVNTGSFNAGSVNTGLWNSGHTNTGALNSGTLNTGFGSSIIQTVANSGFGNTGTGNSGFNNFGDNNSGYGNAGVAGGPGQNNAGIGNQGTLHSGIGNTGSNNDSGFGNTGFYNVGFFNTGDNNSGFGNINDVASGFNSGIGNFGNSNSGGFNIGTGWAGFFGSNF
>NC_022663.1|WP_036391794.1|4883392_4883794_-|nuclear-transport-factor-2-family-protein
MPSSTTEAIAEVADRLFTAIENSDRAAVARMWSDDIAVWRAGAHRDDDKARALRVIDWFVSATAERRYEVLDRQIFEDGSGRGFVQQHVLHAAGQTGQSIELRVCIVIKLDTEGLINRIDEYFDPAELAPLLG
>NC_022663.1|WP_023371914.1|4882734_4883268_-|YceI-family-protein
MTTLETLLSDPDAAGAWNLVPDRSAVTFKVKNMWGLLAVKGEFTKFVGRGNLTDQGTVSGYLEVDVASLRTGIRLRDKHLLSADFFEVERFPEIRVVVTALHPTKGKHAELQASFTIKGITDPVTLPVTVTEFSDGSVRIAGETEIDRVQFGLRWNKFGILAVTATASGEVCFVKAP
>NC_022663.1|WP_023371913.1|4881456_4882719_+|PPE-family-protein
MSFWVLPPEINSLRMFIGAGSAPMLQAATAWAGLADELGAAAQSFASVTSGLAGQAWQGPAAAAMAAAAAPYAAWLSAAAAQSAGAAGQARAMVSMFEAAQAATVLPAAVAANRDAFVQLVMSNLFGQNAPAIAFAESIYEEMWAADVSAMSGYYSGAAALASQLVPWQSILKGLPGMGSAGAAGTSAGSGAAGTTNVGGNGEGANVAGGDNAGGASGGPVGGETTNVVNSSTSAGLAQADPMYSNVGQGTAGSGNVGSASLLSGGTTSASGGVATPGMMGVPIPIPATGGNQTGSAGIGVGAGSAGNAAPTRVPEAAAPPAAEVEAAAPQLRVLPNADPEIAAKAAPVPVARVTQSTGSGIPESALRPSRTADVSHRSANTQDQASEAEEKVVSLRPEAEKGKLRPRAKQEPGIQMRGG
>NC_022663.1|WP_023371912.1|4880246_4880870_-|DedA-family-protein
METFILSHHSYLLLPLLTATGIPVPEEVVTVAAGALSSPSVGRLEPGLAILACLAGVLVGDCALYWIGRGLGQTHLGRYHWFARLVDSDRTGHVERILQQHGVKVFLLVRFLLGMRTPLYLAIGALKMDFRRFLVCDVVCATLAVGIFFLLSYLGAGWISGLIHRSEWAATAILLVTAVTGGLYYGVWKRWRVQLSAHGPRLQGKAQ
>NC_022663.1|WP_023371911.1|4879554_4880250_-|methyltransferase-domain-containing-protein
MTQQSPDTTLFFREFCGKFETTGSVMPSTRYLARAMTRHLRRRGPAPIRVLDCGPGTGAFTDRIVDHLRPGDRLDVVEINDSFVRVLQRRFATEPRWQAASNFTNIHEVPFQYFDAAEPYDFIISSLPHSNFPAITVAEILHSYTRLLKPGGVLTYVEYLYLRQIRRTLSRGTQRARIRSVEQLMLSHMSEHEVAHENVLRNVPPARVHHLIAPADGTGGNTGRDWNTLSA
>NC_022663.1|WP_023371910.1|4879023_4879425_-|response-regulator-transcription-factor
MPDSSDALRILVYSNNVQTRQQVMRALGKRLHPDLPELTYVEIATAPMVIQRMDEGGIDLAILDGEATPAGGMGIAKQLKDELSTCPPILVLTGRPDDSWLASWSRAEAAVSHPIDPIVLGRTALGLLRAPAL
>NC_022663.1|WP_023371909.1|4878390_4878768_-|NADH-quinone-oxidoreductase-subunit-A
MNVYIPILVLAALAAAFAVFSVVIASLAGPSRFNRSKLAAYECGIEPTDSSVSSPHATAGQRFPIKYYLTAMLFIVFDIEIVFLYPWAVSFDALGTFALVEMLIFMLTVFVAYAYVWRRGGLTWD
>NC_022663.1|WP_023371908.1|4877787_4878342_-|NADH-quinone-oxidoreductase-subunit-B
MGLEEQLPGGILLSTVEKVAGYVRKNSLWPATFGLACCAIEMMATAGPRFDLARFGMERFSATPRQADLMIVAGRVSQKMAPVLRQIYDQMAEPKWVLAMGVCASSGGMFNNYAIVQGVDHVVPVDIYLPGCPPRPEMLLHAILKLHEKIQEMPLGVNRERAIAEAEEAALLARPTIEMRGLLR
>NC_022663.1|WP_023371907.1|4877071_4877791_-|NADH-quinone-oxidoreductase-subunit-C
MSSPDQDPREAIARADEEVIDVRRGMFGVSGTGDTSGYGRLVRQVTLPGSSPRPYGGYFDDIADRLAEALHGEGVEFDDAIEKVVVYPQGEGAELTLHVRRERLPQVAQRLRDEPELRFEMCLGVNGVHYPHETGRELHAVYPLQSITHNRRLRLEVSVPDSDPHIPSLYSVYPTNDWHERETYDFFGIVFDGHPSLTRIEMPDDWHGHPQRKDYPLGGIPVEYKGAQIPPPDERRGYN
>NC_022663.1|WP_023371919.1|4893946_4894285_-|hypothetical-protein
MTGLHGRPTAAELVAAVADFLEGDVRAATSGQVNFHARVAANALRMVERELLSSGDAEVRTALADLGFADEAALAAAIRAGELDGRDEEVMACLRALVRHRLAVAHPGYDSE
>NC_022663.1|WP_023371920.1|4894281_4895247_-|phosphotransferase-family-protein
MTLLEDLAALLDPLLGAEVAIENLRVLTGGASRTTWAFDAVVGAERRPLILRIGPPDDVHAGMELEARVQAAAAAAGAPVPHILLADDSPAALGNPFLICEEVKGETIVRRIQRQLDDPGRTRLLRQCARALAAIHRAEWNGLGLVREDPLGQWRDRLDSMGDTTATFEWAFRWLRARRPPPSTAVLVHGDFRMGNLIVDGSDLAAVLDWELVHVGEAYEDLAWFCVRAWRFGAPASLGAGGLGSIESLLQAYEEAGGATVDRAAFRWWLVLATLRWGVICRYQAERHLSGRTRSVELAAIGRRVCENEWDLLELLEAVGR
>NC_022663.1|WP_023371921.1|4895243_4896482_-|acyl-CoA-dehydrogenase-family-protein
MDFSLPEHLPGLLAEMDEFIESDIKPLERQHIQYFDHRREHARTDWDNGGVPRREWEDLLAEMRRRADQAGWLRYGLPSRFGGRDGTNVDMAVIREHLAHKGLGLHNDLQNESSIVGNFPQVIMMDRFGTEAQKKEWTEALITGERSMAFGLTEPSHGSDATWLETRAERDGNSWVINGAKRFNTGVHRATHDLVFARTSGEPGQARGITAFLVPTDTPGFTVPYYWWTLNMPTDHGEVALEDVRVSGDAVLGEVDRGLEVGQTFLHENRIRQAASSLGAAQYCIDRAVDYANERRVFGKPLSVNQAVQWPLVELQTEAQMVRLLVYYAADQLDRNHHMEVSDKVAMANYRANRLVCEAADRAMQVFGGMGYSRHEPFEHIYRHHRRYRITEGAEEIQIRRVAQRLFKFGKK
>NC_022663.1|WP_023371922.1|4896493_4897114_-|TetR/AcrR-family-transcriptional-regulator
MAAGVLTAKGRQTRQAIEQAARKLFAERGFHGTTLADITSAAGKSPAVFYRYFSDKEDLLAALAESFLHDVVAPSGLSVHLPDTPDDDTFFTSVVTGYWNIFKQNIGIMIAVAQLAATQRRFAAVQNEFRRFGMDIVAASVRRAQEQGYGAELHPQHTAAAIALLFENFTTVFVGRSGPENLRLDISDEDAIKTLSMIWKKTLYGT
>NC_022663.1|WP_023371923.1|4897113_4898010_-|hydroxymethylglutaryl-CoA-lyase
MNQHVTIREVSLRDGLQIEKPIPLAAKLELLAAIAATGVREVEATAFVSPSKVPAMADAAELAAELHRYPDIEFSALVASPNGAKRAIAAGLRAIEYVVAASDSFSAANVGRSSAEATSQIGEILAIARGSGVIVEVIVATAWDCPFDGPTPSQRVLDIAAVARGLGVDRFSIADTIGTATPGRVSSLIAQLHPVIGDIALGGHFHNTRGAGLASAYAAVCSGVTRLDASVGGLGGCPFAPGATGNIATEDLVYLLADSGFEVHIDLPAAIAAAEVAKSVVGHDLPGALLRAGDRIRN
>NC_022663.1|WP_023371924.1|4898006_4899215_-|CoA-transferase
MTAPTGPLDGIRVLELGTLIAGPFAGRLLGDMGADVIKVEPPGAPDPLRTWGQAELNGHHVFWTVHARNKRAVTLDLRRPRGRELFLELVEKSDIAVENFRPGTLEKWNLGYDVLSERNPGIILVRVSGYGQTGPDAHKAGYASVAEAASGLRHLNGFPGGPPPRLALSLGDTLAGMFGAQGALAALYRRGVTGRGQVVDVALTESCLAVQESTIPDYDVGGVVRGPSGTRLEGIAPSNIYRSADGSWVVIAANQDTVFARLCKAMGRPELVTDERFATHGARGRNQDELDAIIGAWAAERRPGEIIETLSAAGVIAGPINTVAEVVDDPQLRARGMLVEHYDERVERSVLGPGIVPVLSESPGRVRSAGPPHPGRHNDDVYIGLLGKTVEELTDLRAEGVL
>NC_022663.1|WP_023371925.1|4899211_4900393_-|alpha/beta-fold-hydrolase
MTTRHDYQRIPYLVAFQNNSGVRDVYGGLAEITVLESYLLRPSDKPSDTALVFMHPIGGGAYLPMINALARAGHHVIYCNSRFRGTDSGLLMEKVVEDLGECIKDAKARLGYQKVVLAGWSGGGSLSMFYQQQAQHATVTSSPSGDGPDLTRLDLPAADGIMLLAAHISRHGTLTEWLDASILDETDPTKRDPELDLYHPDNPNQPPYSQEFLARYRQAQIDRNRRITAWVKDKLAELAARGRPDDEFCFVVHGTMADPRWLDPTVDPNERTPGTCYLGDPRVVNMSPVGLARFCSLRSWLSQWSYDDARGDGVACARDLAVPALVIGNLADDACTPSHTRRLFDAIGNSDKEMYEIPGATHYYAGPNQRDKLAHAVDVVTDWLIRHDFASTR
>NC_022663.1|WP_023371926.1|4900394_4901498_-|homogentisate-1,2-dioxygenase
MESFVHLRKGRTPRRLHADLDGLKDDELGRGGFTGRTANIYRRHDPTAYRAVGPLRPLDVLSDDLKPSDATDANGGPLLMFHNIDCRILLSRRHQAMPFYTRHVDGDLLCFVHRGSGMAETEFGPLRYREGDWVYIPKACTWRQIPDSETTLLMVEAADEFRVPAPGALGRHFPFDPSQITIPEPAPIDDDDRDQYEVRLIHRPLAEGVPTSLYYQHNPIDVEGWRGDNFPFTFNIGDYNVVTSNSVHLPPTVHLFMQATGVYVMNFLPKPAEGIPGTERTPWYHRNVDYDEIAFFHGGSLYGIPMPPGLISHAPQGVHHGAPEKARQRARRKFDEYSTVDWQVIAIDTRRRLTPCAEMLAHDLGQH
>NC_022663.1|WP_023371927.1|4901850_4903776_+|PPE-family-protein
MEFLTLPPEVNSARILRGPGPAPLRAAATAWATLSEDLASSATAVSSVMSEISGSAWQGPAAAAMAAAVAPYPGWLGAAATRAAAAGRHAATAAAAYETARTATVPLEMLAQNRSRLVSLVAADVLGLNAPAIAATEAHYEQLWAQDVGAMAGYYAGASAAVAQLTPWQTLLSTLESPVGGMKAAEAAVSASSPSASTAATGVTLVIGGSGYPIPSQSYVNTVVADYVTPTFPGFTTANAQSLYTPAQSYWITGVKTLTEDASWAQGLTILDNAIHAQLATGNNVAVQGFSQGAGIASLEMANLKAEGVPTSSVSFSLIGDPMNPNGGLYSRFDGLTLASMGKSFPGSTPANDYPTVIYTIEYDGFADFPQYPLNLVADANAMLGALYVHPQYPVLTPAQVVTAVQLPTQGPTTTTYYMIPTQNLPLLEPLRALPLGNTVADLIQPDLKVIVNLGYGNPDYGYSTGPANVPTPFGLFPDASPGVVVADLIDGTRQGIGAAAADLGTWHAPAGNPAPNPFALSDLTPPTVAATTIDGIIQGLQTGNTNLTNAVTSATSSAYATLLPTADMLSAILVSLPSYDVNLFLDGVRQALDGDPAGIINAIGYPIAADTGLLTFLSFFLAYAYYGAAKSIAGDFASLI
>NC_022663.1|WP_023371928.1|4903785_4904757_-|NADPH:quinone-oxidoreductase-family-protein
MRAIRVTRLEGPGAVEISEIDEPAGEGVVVDVYAAGAAFPDALLTRGLYQYRPEPPFVLGAEIAGVVRSAPQDAHVCAGDRVVGLTMLTGGMAEVAVLSPDRVFKLPDNVSFEAGAGLLFNDLTVYFALRVRGRLQRGETVLVHGAAGGIGTSALRLAPVLGASRTIAVVSTEEKAAIATAAGATDVVLAEGFKDAVKALTDGRGVDVVVDPVGGDRFTDSLRSLAPAGRLLVIGFTGGEIPTVKVNRLLLNNIDVVGVGWGAWAGKHPGALSEQWAALEQLLSSGELPPPEPVVYPLEQAAAAVASLENRTAKGKVVLRVRD

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Crispr_ID: NC_022663_16

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022663_16

4957401-4957507

Orphan

Consensus_repeat	Method
AACAGCCTGGCCATCGCTACCAGACATCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022663_16

>merge|NC_022663|16|4957401-4957507|CRISPRCasFinder
AACAGCCTGGCCATCGCTACCAGACATCCCACCGCTCCGGAGGTTCTTCCTTATGTGAGCAGTGACCGCCTGAAGCGAACAGCCTGGCCATCGCTACCAGACATCCC

>NC_022663|16|12|4957401-4957507|CRISPRCasFinder
AACAGCCTGGCCATCGCTACCAGACATCCC	ACCGCTCCGGAGGTTCTTCCTTATGTGAGCAGTGACCGCCTGAAGCG
AACAGCCTGGCCATCGCTACCAGACATCCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_022663.1\|WP_023371988.1\|4967172_4967979_+\|spirocyclase-AveC-family-protein	unknown	unknown	gnl\|CDD\|379943
NC_022663.1\|WP_023371978.1\|4958973_4959657_-\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_023371966.1\|4947703_4949287_+\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223354
NC_022663.1\|WP_023371972.1\|4954076_4954970_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|225088
NC_022663.1\|WP_023371985.1\|4965879_4966110_+\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_036391809.1\|4953386_4954076_+\|cell-division-ATP-binding-protein-FtsE	unknown	unknown	gnl\|CDD\|225438
NC_022663.1\|WP_023371986.1\|4966263_4966929_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NC_022663.1\|WP_023371979.1\|4959697_4961485_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_022663.1\|WP_103797782.1\|4961587_4962241_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|274729
NC_022663.1\|WP_023371967.1\|4949287_4950661_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|215457
NC_022663.1\|WP_023371981.1\|4962345_4962516_-\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_080674119.1\|4952886_4953342_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237030
NC_022663.1\|WP_023371965.1\|4947490_4947694_+\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_036391220.1\|4951897_4952884_+\|mechanosensitive-ion-channel-family-protein	unknown	unknown	gnl\|CDD\|366370
NC_022663.1\|WP_080674265.1\|4957660_4958845_+\|PE-domain-containing-protein	unknown	unknown	gnl\|CDD\|376422
NC_022663.1\|WP_023371973.1\|4954972_4955479_+\|SsrA-binding-protein-SmpB	unknown	unknown	gnl\|CDD\|235455
NC_022663.1\|WP_023371974.1\|4955586_4956432_+\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	unknown	unknown	gnl\|CDD\|274422
NC_022663.1\|WP_036391816.1\|4964132_4965767_+\|PPE-family-protein	unknown	unknown	gnl\|CDD\|366325
NC_022663.1\|WP_023371968.1\|4950780_4951911_+\|peptide-chain-release-factor-2	unknown	unknown	gnl\|CDD\|234799
NC_022663.1\|WP_172836661.1\|4963150_4963870_+\|MspA-family-porin	unknown	unknown	gnl\|CDD\|370360

Protein	Function_ID	Function_description	E-value
NC_022663.1\|WP_023371988.1\|4967172_4967979_+\|spirocyclase-AveC-family-protein	gnl\|CDD\|379943	pfam17198, AveC_like, Spirocyclase AveC-like. AveC catalyzes the stereospecific spiroketalization of a dihydroxy-ketone polyketide intermediate in the biosynthetic pathway of Avermectin, a potent antiparasitic agent. Additionally, it has a unique dehydration activity that serves to determine the regiospecific saturation pattern for spiroketal diversity. MeiC, the counterpart in the biosynthesis of AVE-like meilingmycin, also has spirocyclase activity, but lacks the dehydratase activity.	1.75548e-85
NC_022663.1\|WP_023371966.1\|4947703_4949287_+\|FAD-binding-oxidoreductase	gnl\|CDD\|223354	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion].	8.04027e-69
NC_022663.1\|WP_023371972.1\|4954076_4954970_+\|ABC-transporter-permease	gnl\|CDD\|225088	COG2177, FtsX, Cell division protein [Cell division and chromosome partitioning].	1.90971e-87
NC_022663.1\|WP_036391809.1\|4953386_4954076_+\|cell-division-ATP-binding-protein-FtsE	gnl\|CDD\|225438	COG2884, FtsE, Predicted ATPase involved in cell division [Cell division and chromosome partitioning].	2.58522e-135
NC_022663.1\|WP_023371986.1\|4966263_4966929_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	1.70851e-15
NC_022663.1\|WP_023371979.1\|4959697_4961485_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	3.93177e-96
NC_022663.1\|WP_103797782.1\|4961587_4962241_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|274729	TIGR03695, menH_SHCHC, 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase. This protein catalyzes the formation of SHCHC, or (1 R,6 R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate, by elmination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Note that SHCHC synthase activity previously was attributed to MenD, which in fact is SEPHCHC synthase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone].	1.6183e-30
NC_022663.1\|WP_023371967.1\|4949287_4950661_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|215457	PLN02852, PLN02852, ferredoxin-NADP+ reductase.	4.26634e-154
NC_022663.1\|WP_080674119.1\|4952886_4953342_+\|hypothetical-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	1.39515e-06
NC_022663.1\|WP_036391220.1\|4951897_4952884_+\|mechanosensitive-ion-channel-family-protein	gnl\|CDD\|366370	pfam00924, MS_channel, Mechanosensitive ion channel. Two members of this protein family of M. jannaschii have been functionally characterized. Both proteins form mechanosensitive (MS) ion channels upon reconstitution into liposomes and functional examination by the patch-clamp technique. Therefore this family are likely to also be MS channel proteins.	2.96996e-40
NC_022663.1\|WP_080674265.1\|4957660_4958845_+\|PE-domain-containing-protein	gnl\|CDD\|376422	pfam00934, PE, PE family. This family named after a PE motif near to the amino terminus of the domain. The PE family of proteins all contain an amino-terminal region of about 110 amino acids. The carboxyl terminus of this family are variable and fall into several classes. The largest class of PE proteins is the highly repetitive PGRS class which have a high glycine content. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	1.7373e-28
NC_022663.1\|WP_023371973.1\|4954972_4955479_+\|SsrA-binding-protein-SmpB	gnl\|CDD\|235455	PRK05422, smpB, SsrA-binding protein SmpB.	3.05424e-86
NC_022663.1\|WP_023371974.1\|4955586_4956432_+\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	gnl\|CDD\|274422	TIGR03083, TIGR03083, uncharacterized Actinobacterial protein TIGR03083. This protein family pulls together several groups of proteins, each very different from the others. They share in common three conserved regions. The first is a region of about 38 amino acids, nearly always at the N-terminus of a protein. This region has a bulky hydrophobic residue, usually Trp, at position 29, and a His residue at position 37 that is invariant, so far, in over 150 instances. The second conserved region has a motif [DE]xxxHxxD. The third conserved region contains a hydrophobic patch and a well-conserved Arg residue. Most examples are found in the Actinobacteria, including the genera Mycobacterium, Corynebacterium, Streptomyces, Nocardia, Frankia, etc. The pattern of near-invariant residues against a backdrop of extreme sequence divergence suggests enzymatic activity and conservation of active site residues.	2.78315e-29
NC_022663.1\|WP_036391816.1\|4964132_4965767_+\|PPE-family-protein	gnl\|CDD\|366325	pfam00823, PPE, PPE family. This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	1.31367e-61
NC_022663.1\|WP_023371968.1\|4950780_4951911_+\|peptide-chain-release-factor-2	gnl\|CDD\|234799	PRK00578, prfB, peptide chain release factor 2; Validated.	0
NC_022663.1\|WP_172836661.1\|4963150_4963870_+\|MspA-family-porin	gnl\|CDD\|370360	pfam09203, MspA, MspA. MspA is a membrane porin produced by Mycobacteria, allowing hydrophilic nutrients to enter the bacterium. The protein forms a tightly interconnected octamer with eightfold rotation symmetry that resembles a goblet and contains a central channel. Each subunit fold contains a beta-sandwich of Ig-like topology and a beta-ribbon arm that forms an oligomeric transmembrane barrel.	5.08982e-47

>NC_022663.1|WP_023371974.1|4955586_4956432_+|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme
MADRPLTQLDKSDVLAGLFAVWDSLDALLDGLPEADWQSASPLPGWNVKAVVSHIIGTESFLLGIGAPEADVDLSTLEHVRNPIGVMNESWVIHLSAESGASLLKRFREVTNKRRKALESMSDDDWNAATTTPAGPDTYGRFMRIRTFDCWMHEQDIRQAVQRPSSDDELGGRAGELSLDEMSSSMGFVVGKLAKAPDGSRVLFELTGPLARTMRVSVDGRAQVVDDFGGQEPTATIRMDGLQFTRLAGGRPMSPARSQDVELGGDEDLAGQIVKRLNFVI
>NC_022663.1|WP_023371973.1|4954972_4955479_+|SsrA-binding-protein-SmpB
MAGQSKQAKAAGKKIGRKIIATNRKARHNYSIIEVFEAGMALQGTEVKSLREGHASLVDAFATIDDGEIWLRNLHIPEYQHGSWTNHEPRRNRKLLLHRRQIDTLIGKLREGNFALVPLSLYFTEGKVKVEIALARGKHAHDKRQDLARRDAQREVIRELGRRAKGMG
>NC_022663.1|WP_023371972.1|4954076_4954970_+|ABC-transporter-permease
MRFGFLLNEVLTGLRRNVTMTIAMILTTAISIGLFGGGLLVVRLADNSRAIYLDRVETQVFLTDDVSANDPACDSDPCKALREKIEKRSDVKAVRFLNRQQAYDDAIRKFPQYKDVAGKDSFPASFIVKLENPEQHKDFDTAMQGQPGVLSVLNQKDLIDRLFAVLDGLSNAAFAVALVQAIGAVLLIANMVQVAAYTRRTEIGIMRLVGASRWYTQLPFLVEAMLAATVGVLIAIGGLIVVRAMFLENALNQFYQANLIARVDYADILYIAPWLLLLGVAMAGLTAYATLRIYVRR
>NC_022663.1|WP_036391809.1|4953386_4954076_+|cell-division-ATP-binding-protein-FtsE
MITLDHVTKQYKSSARPALDDVNVKIDKGEFVFLIGPSGSGKSTFMRLLLAAETPTSGDVRVSKFHVNKLRGRNVPKLRQVIGCVFQDFRLLQQKTVYENVAFALEVIGKRTDAINRVVPEVLETVGLSGKANRLPDELSGGEQQRVAIARAFVNRPLVLLADEPTGNLDPDTSKDIMDLLERINRTGTTVVMATHDHHIVDSMRQRVVELSLGRLVRDEQRGVYGMDR
>NC_022663.1|WP_080674119.1|4952886_4953342_+|hypothetical-protein
MNFWPNVLGKRDGNGARRTPSHLFGGRVRTSTVVLIVVFLAVWWTYDTYRPEPAPARPAQVVPPGFVPDPDYTWVPRERVQPPGTTSLRPTPTTVPTTEPTTTTTTPTPPPGSPPCLLPPPFCPASTTPSTPEPSPQPGPGPSPSSTPPAS
>NC_022663.1|WP_036391220.1|4951897_4952884_+|mechanosensitive-ion-channel-family-protein
MTATNTTIRALSVAQRWHDFWRGHIGEWIITRGLRVVMLLIAAVLAARFVSWVAQRVTRRLDLGFAESDALVRSEATKHRQAVASVISWVSIVLIGIVVVMQIADVLQFSVGGLVAPATVVGAALGFGAQQLVRDLLAGFFIIVERQYGFGDLVKLTIMGSATDATGTVENVTLRVTRLRSADGEVFTVPNGQIVKSVNLSKDWARAVVDIPVSTNADLNRVNEVLHQECEHARDDAVLGELLLDSPTVMGVESIELDTVTLRLVARTLPGKQFEAGRQLRVLVIRALARAGIVTAADATVGLVEDPAVPAAEAAEAAEPSEVKGAVR
>NC_022663.1|WP_023371968.1|4950780_4951911_+|peptide-chain-release-factor-2
MEPDRQADRRAEIAALDSTLTTVERVLDVDALRAKIDKLEHEASDPKLWDDQARAQRVTSELSHAQGELRRVEQLRSRLDDLPVLYELAAEEEGEAAAEALAEADAELKALHAEIEATEVRTLLSGEYDEREALVTIRSGAGGVDAADWAEMLMRMYIRWAEQHKYPVEVFDTSYAEEAGIKSATFAVHAPFAYGTLSVEQGTHRLVRISPFDNQSRRQTSFAEVEVLPVVETTDHIDIPEGDVRVDVYRSSGPGGQSVNTTDSAVRLTHIPTGIVVTCQNEKSQLQNKVAAMRVLQAKLLERKRLEERAELDALKGEGGSSWGNQMRSYVLHPYQMVKDLRTEYEVGNPAAVLDGDIDGFLEAGIRWRNRKDDSN
>NC_022663.1|WP_023371967.1|4949287_4950661_-|FAD-dependent-oxidoreductase
MRPHHRPYHVAIVGSGPSGFFAAASLLKAADGSDHIDVAVDMLEMLPTPWGLVRSGVAPDHPKIKSISKTFEKTAEDPRFRFFGNILVGEHVSPVELAERYDAVVYAVGAQSDKPLNIPGEDLPGSIAAVDFVGWYNAHPNFEHAAPDLSGARAVVVGNGNVAIDVARILVTDPEVLACTDIADHALESLRPCGVREVVLVGRRGPLQAAFTTLELRELGELEGVDVVVDPAQLAGISDEDAAAAGKTAKQNIKVLRDYAQRAPREGHRRIVFRFMTSPIEIRGDGRVEQIVLGRNELVADESGWVSARDTGEREELPAQLVVRSVGYRGVPTPGLPFDEKRGTIPNTAGRVEGSRNEYVVGWIKRGPTGVIGTNKKDSQDTVDTLIADLAATEALTEFPPDHGEQLAAWLASRQPQLVTTAQWKIIDRFERAAGEPHGRPRVKLPNLAELLRVGHG
>NC_022663.1|WP_023371966.1|4947703_4949287_+|FAD-binding-oxidoreductase
MRSWWGWGDVEEALSDGETQALAARVATLLPGHDLTDHQPPDPGALGLAPPRITAPTSLAGLCSADFLDRAGHARGKAFRDVARNLQGRLDHVPDLIVRPRTERDVVDVLDWCTRERISVIPYGGGSSVVGGVEPRFDEPAVTLDLGALDAVLDIDRVSRAARIQAGALGPSIENQLRPYDLTLRHFPQSFGYSTLGGWLATRSGGHFATLYTHIDDLTASMRVVTAAGISESRRLPGSGAGPSPDRLFLGSEGTLGIITEAWMRLQDRPRWQLTASVAFDEWAAAVTATRTIAQAGLYPANCRLLDPAEAFLNAGTTVGGGLLVLAFESADHPVDAWLQRALDIAADHGGTVTARRGRENISDPTQNDASTNWRSAFLRMPYQRDALARRGVIAETFETACTWAGFDTLHAAVTDAARSAIESVCGAGLVTCRFTHVYPDGPAPYYGIYAAGRWGSLDAQWDDIKAAVSEAISTAGGTITHHHAVGRDHRPWYDRQRPDPFAAALRAAKSALDPAGILNPGVLVDF
>NC_022663.1|WP_023371965.1|4947490_4947694_+|hypothetical-protein
MAGKEIDRVRATSALAVIKQHPGMVLFALSPVLALLAVIWWLAGTGWAIVTALVLLVVGGALVVVKR
>NC_022663.1|WP_080674265.1|4957660_4958845_+|PE-domain-containing-protein
MSYVFAFPELMSGAATDVASIGSLVATANQGMAAATTAVVAAAEDEVSEAIAAIFSAHGEGYLALSAQAAAFHERFVQALAGAAGAYATAEAAGAAPLATFEQAVLGVQVEIQQIPTTIAAGFSSGLASLTSIPGNPLLMLLASDIPPLSWVLGNSPPPLLNLLLGQTVQYTTYQGMSVVQITPAAPTGEYVVALHGGAYILPASLFHWINYSVTAYQTGATFEVPIYPLLQQGGTAATVVPQTAGFISSLIAQHGAQNVSVVGDSAGGNLALGAVQYLVSQSEPVPSSMVLLSPWLDVGTGGLGAAWAGNLPANNYLVSPLYGSLDGLPPTYVYSGSLDPLAQQAAVLQHAALAQGAPMSFALEPGGIHDWVLLTPGGLLYWPQINQQLGIVA
>NC_022663.1|WP_023371978.1|4958973_4959657_-|hypothetical-protein
MTYPHQFGVLQIVLAGVAVAAVVMLLSAVVGRRRTVHSSSAESAPRGRRLRFRPGRAAGGVVLLVVSILLLWFATLVQTYVGLTGEIKAAHVVATPVSNEAHRLNVDLTLYDDAGKAYAHQTYEVEGDMWVLQADIVELQHWVNILGMHSGYKVTRLFGQRLDGVSPTQHQIMLNGGDGDFFDDMRGGKWWTKPFVRAAYGNAVIAAPGAFDVYISQDAIKARASDG
>NC_022663.1|WP_023371979.1|4959697_4961485_-|serine/threonine-protein-kinase
MPFDNGEVFAGYVIQRLLGTGGMGEVYLAQHPRLPRHDALKVLSLAATADQEFQARFKREAELAATLWHPHIVGVLDRGEFNGRLWISMEYVDGTDAGRLVRERYPHGMPEQDVAEIVTAVADALDFGHDRRLLHRDVKPENILVTAPDGHRRRVLLTDFGIARRIDDVSNLTDVNVAIGTISYVAPEQLLGKPLDGRADQYALAATTFYLLTGAPPFQDSNRAVVVSNHLNTPPPRISERRPELAHLDAVLARALAKDPNQRYPTCTAFALALTQHGPHRDAALAAGPAEDLRSGGRPATQRLERLVVQGIARAVAQSAVGAQSQVGILSFQVVPYEPLGNRRAPLPVEIQTDLVAGQLADGDEVEITGLWDGETLDADKIVNLSAGARPKRPRPEASATSPRDKSPKGRKLWIAALVAIVGVIVLTAAAVVYFTDSFGTRTRPGPIVKPVSATVFSPDGAPDNPQQASLAIDGNPNTAWSTVTYRDAVPFPKFIEGMGLLLHLAQPTALSEVTIDVSSTGTQVQIRSAPSQSPTKLADTTALTPNTPLQPGHNVIPVHDRAKTSNVLVWISTLGTTNGESRTSISEITLRAAG
>NC_022663.1|WP_103797782.1|4961587_4962241_-|alpha/beta-fold-hydrolase
MWEPNVDALSVDRPVIVWDQRGHGSSDAPDDIDAYSEQLSVADMAAILDAAGTDRAVLGGMSLGGYLSLAFHLVHPQRVAALVLVDTGPGYRNDEARAKWNAWVERRARQLERGGAPADVSPELTQAVHEHPEGLPRAARGVMAQKDARVITSLDSITVPTLVIVGAQDTDYLAAADYMARKIPTARKVVIENARHAANMDQPEAFNIAVREFLDHL
>NC_022663.1|WP_023371981.1|4962345_4962516_-|hypothetical-protein
MAGSVIDGAVEAVELDRLGFENACGAVGMTKEHPLQQLIRRLWACRDQKHWSEVVP
>NC_022663.1|WP_172836661.1|4963150_4963870_+|MspA-family-porin
MPSVSAVMPISAVVRRAAVLALCLVVSVTAPSAGAQPDAEPPPGAAPPSDGSVPPGTPVRVNTPDGWVLALGGKDEKHVPVAPLTTALSSREYLSSGIFGASLTGPEPPRGVFEVGYEIGCGIDQSTSNGYVMANGSGISPSIAAELPLGPGQPPIVIPLASGQYNNVVSVGLKPGFVVIVPVVRKDFKGPSPWIMISDFHIKIDGCVGQSFIRSYATLTRITDESDVVLSYVGSTKAV
>NC_022663.1|WP_036391816.1|4964132_4965767_+|PPE-family-protein
MWPPEVNSVLLLEGPGSGPMLEAAAAWDGIGTELSSAANAFGSITSDLGGQAWQGAASASMTTAASRYVDWLGRTAAQAEQSAAQARAAAIAYEAALAGIVHPELITANRGQLVSLVVANLFGQNAPAIAAAEAAYEQMWAQDVVAMGGYHSSASATVALLAPWEQALQNLPGLPGELAKAIGNGFALAEQEIQQTPTALAAAFTRVSDTVITGIFGSPANPPFPATEAGTFTGTPSLATRIEEAALWPVKPLLNLSGLETQISAPGSPLLALFASDIPPLSWFLGNSPPPFLNLLLGQTVQYTTYNGMSVVQITPAHPTGEYVVAIHGGAFIFPPSFLHWINYSVMAQQTGATVQVPIYPLLQQGGTAGTVVPTMAGFISTQIAQHQASNVSVIGDSAGGNLALAATQYLVDHGGPVPSSMVLVSPWLDVGMTNPNIALIQDPLLPVGPAQQIGKVWAGNLDVNDPLVSPLNGSLSGLPPTYVYSGNLDILAADVLVLQQAAATQGAPISFVLANGQIHDWILLTPDGFQYWPQINRELGIAA
>NC_022663.1|WP_023371985.1|4965879_4966110_+|hypothetical-protein
MAVKSLTGFAGAVHEAVVAVLDAIVTAGDDRREHLEHAKRAIEKALHDSRSGAEWYLAEHLRQGIKDVEARTRDAA
>NC_022663.1|WP_023371986.1|4966263_4966929_-|TetR/AcrR-family-transcriptional-regulator
MSQRLSPRKGPAAQAAVQPFRRPRGEPRRLLLDAARELFARQDYRSTTTREIAQAAGVSEYLLFRHFGSKAGLFREALVLPFTSFVDEFSRTWQSVVPEETDEEELARHFVEQLYDVLVDHRGLLLTLAASEAFGEEETEDTGIADMRRAIAVLGQISAEGMRLRGIRSSQPDLPAHSTVAMIVGMVALRSTFFGSVPPPREAIVDELVQAILHGFLHRRD
>NC_022663.1|WP_023371988.1|4967172_4967979_+|spirocyclase-AveC-family-protein
MSTQLTPLLTAAVIFGWGSGIVFTATGGYLSVRRRRLHPLLLLCISAISFSWIEAPYDWAMYAQFPPALPRAPSWWPLNMTWGGLPSSVPVGYIGYFVLPAVIGATLGRRLSARFGWLAGNKRPITLLIVGLVVGFCWAFVFNAFVGARLGVFHYGYVIPGLAIFEGTKHQYPVYDSLALGVQMMVFTYLLGRTDSQGRNVIELWADKRSTSRLQSAVLSVVAVVVIGNLLYGAVFAPHLVTKLGGWVTAGPTEQLFPGVSNQPRQGG

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Crispr_ID: NC_022663_17

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022663_17

5180781-5180868

Orphan

Consensus_repeat	Method
CGCCCCCACAAGTGGGAGGTACCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022663_17

>merge|NC_022663|17|5180781-5180868|CRISPRCasFinder
CGCCCCCACAAGTGGGAGGTACCCCCACCCGCTTGCGGGCGACGAAGCGATGAGGCGGGGACGCGCCCCCACAAGGGGGAGGTACCCC

>NC_022663|17|13|5180781-5180868|CRISPRCasFinder
CGCCCCCACAAGTGGGAGGTACCCC	CACCCGCTTGCGGGCGACGAAGCGATGAGGCGGGGACG
CGCCCCCACAAGGGGGAGGTACCCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_022663.1\|WP_099185093.1\|5175950_5176952_+\|ketol-acid-reductoisomerase	unknown	unknown	gnl\|CDD\|235491
NC_022663.1\|WP_023372189.1\|5190719_5191421_-\|IclR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224332
NC_022663.1\|WP_042312844.1\|5172875_5173283_-\|PH-domain-containing-protein	unknown	unknown	gnl\|CDD\|371225
NC_022663.1\|WP_042313923.1\|5181903_5183061_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|341028
NC_022663.1\|WP_155254711.1\|5187000_5187429_+\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_042313921.1\|5170701_5171823_-\|sorbosone-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|225044
NC_022663.1\|WP_023372176.1\|5177027_5177627_-\|NAD(P)H:quinone-oxidoreductase	unknown	unknown	gnl\|CDD\|179647
NC_022663.1\|WP_023372184.1\|5185602_5186853_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|341028
NC_022663.1\|WP_023372180.1\|5180896_5181907_+\|3-isopropylmalate-dehydrogenase	unknown	unknown	gnl\|CDD\|179579
NC_022663.1\|WP_023372188.1\|5190128_5190641_-\|PPOX-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274679
NC_022663.1\|WP_023372174.1\|5175398_5175917_+\|acetolactate-synthase-small-subunit	unknown	unknown	gnl\|CDD\|183365
NC_022663.1\|WP_023372173.1\|5173554_5175399_+\|acetolactate-synthase-large-subunit	unknown	unknown	gnl\|CDD\|236098
NC_022663.1\|WP_023372177.1\|5177623_5179054_-\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224154
NC_022663.1\|WP_036391277.1\|5187439_5188258_+\|fumarylacetoacetate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|223257
NC_022663.1\|WP_080674133.1\|5188254_5189742_+\|glutamate--tRNA-ligase	unknown	unknown	gnl\|CDD\|234953
NC_022663.1\|WP_023372171.1\|5172023_5172869_+\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|225168
NC_022663.1\|WP_099185092.1\|5170024_5170558_+\|flavin-reductase	unknown	unknown	gnl\|CDD\|376575
NC_022663.1\|WP_036391914.1\|5184556_5185246_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NC_022663.1\|WP_023372182.1\|5183152_5184502_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|341028
NC_022663.1\|WP_023372179.1\|5179164_5180751_+\|phosphoglycerate-dehydrogenase	unknown	unknown	gnl\|CDD\|237436

Protein	Function_ID	Function_description	E-value
NC_022663.1\|WP_099185093.1\|5175950_5176952_+\|ketol-acid-reductoisomerase	gnl\|CDD\|235491	PRK05479, PRK05479, ketol-acid reductoisomerase; Provisional.	0
NC_022663.1\|WP_023372189.1\|5190719_5191421_-\|IclR-family-transcriptional-regulator	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	8.50985e-55
NC_022663.1\|WP_042312844.1\|5172875_5173283_-\|PH-domain-containing-protein	gnl\|CDD\|371225	pfam10756, bPH_6, Bacterial PH domain. This domain has a bacterial type PH domain structure. This domain was previously known as DUF2581. This family is conserved in the Actinomycetales. Although several members are annotated as RbiX homologs, RbiX being a putative regulator of riboflavin biosynthesis, the function could not be confirmed.	6.81933e-17
NC_022663.1\|WP_042313923.1\|5181903_5183061_-\|MFS-transporter	gnl\|CDD\|341028	cd17475, MFS_MT3072_like, Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily. This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.5314e-77
NC_022663.1\|WP_042313921.1\|5170701_5171823_-\|sorbosone-dehydrogenase-family-protein	gnl\|CDD\|225044	COG2133, COG2133, Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism].	8.85692e-91
NC_022663.1\|WP_023372176.1\|5177027_5177627_-\|NAD(P)H:quinone-oxidoreductase	gnl\|CDD\|179647	PRK03767, PRK03767, NAD(P)H:quinone oxidoreductase; Provisional.	5.63477e-55
NC_022663.1\|WP_023372184.1\|5185602_5186853_-\|MFS-transporter	gnl\|CDD\|341028	cd17475, MFS_MT3072_like, Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily. This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.19602e-78
NC_022663.1\|WP_023372180.1\|5180896_5181907_+\|3-isopropylmalate-dehydrogenase	gnl\|CDD\|179579	PRK03437, PRK03437, 3-isopropylmalate dehydrogenase; Provisional.	0
NC_022663.1\|WP_023372188.1\|5190128_5190641_-\|PPOX-class-F420-dependent-oxidoreductase	gnl\|CDD\|274679	TIGR03618, Rv1155_F420, PPOX class probable F420-dependent enzyme. A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomyces, make F420. The Partial Phylogenetic Profiling algorithm identifies this members of this protein family as high-scoring proteins to the F420 biosynthesis profile. A member of this family, Rv1155, was crytallized after expression in Escherichia coli, which does not synthesize F420; the crystal structure shown to resemble FMN-binding proteins, but with a recognizable empty cleft corresponding to, yet differing profounding from, the FMN site of pyridoxine 5'-phosphate oxidase. We propose that this protein family consists of F420-binding enzymes. [Unknown function, Enzymes of unknown specificity].	9.57717e-34
NC_022663.1\|WP_023372174.1\|5175398_5175917_+\|acetolactate-synthase-small-subunit	gnl\|CDD\|183365	PRK11895, ilvH, acetolactate synthase 3 regulatory subunit; Reviewed.	2.95825e-90
NC_022663.1\|WP_023372173.1\|5173554_5175399_+\|acetolactate-synthase-large-subunit	gnl\|CDD\|236098	PRK07789, PRK07789, acetolactate synthase 1 catalytic subunit; Validated.	0
NC_022663.1\|WP_023372177.1\|5177623_5179054_-\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224154	COG1233, COG1233, Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism].	1.37084e-78
NC_022663.1\|WP_036391277.1\|5187439_5188258_+\|fumarylacetoacetate-hydrolase-family-protein	gnl\|CDD\|223257	COG0179, MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism].	7.31847e-109
NC_022663.1\|WP_080674133.1\|5188254_5189742_+\|glutamate--tRNA-ligase	gnl\|CDD\|234953	PRK01406, gltX, glutamyl-tRNA synthetase; Reviewed.	0
NC_022663.1\|WP_023372171.1\|5172023_5172869_+\|DoxX-family-protein	gnl\|CDD\|225168	COG2259, COG2259, Predicted membrane protein [Function unknown].	1.78642e-24
NC_022663.1\|WP_099185092.1\|5170024_5170558_+\|flavin-reductase	gnl\|CDD\|376575	pfam01613, Flavin_Reduct, Flavin reductase like domain. This is a flavin reductase family consisting of enzymes known to be flavin reductases as well as various oxidoreductase and monooxygenase components. VlmR is a flavin reductase that functions in a two-component enzyme system to provide isobutylamine N-hydroxylase with reduced flavin and may be involved in the synthesis of valanimycin. SnaC is a flavin reductase that provides reduced flavin for the oxidation of pristinamycin IIB to pristinamycin IIA as catalyzed by SnaA, SnaB heterodimer. This flavin reductase region characterized by enzymes of the family is present in the C-terminus of potential FMN proteins from Synechocystis sp. suggesting it is a flavin reductase domain.	4.60666e-30
NC_022663.1\|WP_036391914.1\|5184556_5185246_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	6.95647e-18
NC_022663.1\|WP_023372182.1\|5183152_5184502_-\|MFS-transporter	gnl\|CDD\|341028	cd17475, MFS_MT3072_like, Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily. This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.93712e-97
NC_022663.1\|WP_023372179.1\|5179164_5180751_+\|phosphoglycerate-dehydrogenase	gnl\|CDD\|237436	PRK13581, PRK13581, D-3-phosphoglycerate dehydrogenase; Provisional.	0

>NC_022663.1|WP_023372179.1|5179164_5180751_+|phosphoglycerate-dehydrogenase
MNLPVVLIADKLAQSTVAALGDQVEVRWVDGPDRAKLLAAVPEADALLVRSATTVDAEVLAAAPKLKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIHSAAEHAIALLLAAARQIPAADATLRVRTWKRSSFSGTEIFGKTVGVVGLGRIGQLVAQRVAAFDAHVVAYDPYVSPARAAQLGIELLPLDDLLARADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEAALADAIGGGHVRAAGLDVFASEPCTDSPLFDLPQVVVTPHLGASTVEAQDRAGTDVAESVRLALAGEFVPDAVNVGAGVVSEEVAPWLDLVRKLGVLAAALSDGAPVSLSVQVRGELASEEVEVLRLSALRGLFSAVIDEPVTFVNAPALAAERGVSAEITKASESPNHRSVVDVRAVGADGSAVNVSGTLYGPQLTQKVVQINGRHFDMRAEGINLIVHYVDQPGALGKIGTLLGAAGVNIHAAQLSEDVEGPRATILLRLDQAVPDDVRSAMVAAVGANKIEVVDLS
>NC_022663.1|WP_023372177.1|5177623_5179054_-|NAD(P)/FAD-dependent-oxidoreductase
MDVTVVGSGPNGLAAAVICARAGLKVNVIEAQPTFGGGARSAADVEFPGVLHDVCSAVHPLALASPFFAEFNLPARGVTLAVPEIAYANPLPGRPAAIAYHDLARTSTELDDGASWRRLLGPLVTNFAAVVDFMLGDKRSVPAALLPAMHLGLRMLAQGTPAWRSLAGEDSRALFTGVAAHAISRLPSLVSAGAGLMLATLAHSVGWPIPVGGSQVIADALIDDLRAHGGELTAGVEVTSPPGGVVVFDTAPTTLLHVYRDALPDRYAKALRRYRFGSGAAKVDFVLSDEIPWPDSRLSQAPTLHLGGTREQMARAEAEVAAGRHADWPMVLAASPHLADPGRVDGAGRRPFWTYAHVPSGSTVDATETVTRVVERLAPGFRDVVVAARSVPAARMVEHNANYVGGDISVGANSVWRAIAGPTPRLNPWRTPVPGVYLCSAATPPGPGVHGMSGYYAARTLLRHEFGITDMPKLSP
>NC_022663.1|WP_023372176.1|5177027_5177627_-|NAD(P)H:quinone-oxidoreductase
MTKLAVIYYSATGHGTTMAQRIAAAAEAAGAEVRVRPVAETRDPASFAHNPAWTANYEATKDLPAATGEDIVWADAVIFGSPTRFGCVAAQLRNFLDSLGGLWAEGKLADKLYAAFTSSNTLHGGQETTLLTLYVTLMHFGGIIVPPGYTDPLKFVDGNPYGASLVSTHDNIHEFDEPTVNALDHLARRVVEVAGRLTS
>NC_022663.1|WP_099185093.1|5175950_5176952_+|ketol-acid-reductoisomerase
MFYDDDADLSIIQGRKVGVIGYGSQGHAHSLSLRDSGVQVRVGLKEGSKSRAKVEEQGLEVDTPAEVAKWADVIMLLAPDTAQAEIFSNDIEPNLKPGDALFFGHGLNIHFNLIKPPADVTVAMVAPKGPGHLVRRQFVDGKGVPCLIAVDQDPTGNGEALALSYAKAIGGTRAGVIKTTFKDETETDLFGEQAVLCGGTEELVKAGFDVMVEAGYPPEMAYFEVLHELKLIVDLMYEGGIARMNYSVSDTAEFGGYLSGPRVIDASTKDRMREILREIQDGTFVKKLVANVEGGNKELEQLRKENAEHPIEVTGKKLRDLMSWVDRPITETA
>NC_022663.1|WP_023372174.1|5175398_5175917_+|acetolactate-synthase-small-subunit
MSSSSSPKTHTLSVLVEDKPGVLARVAALFSRRGFNIESLAVGATEQKDMSRMTIVVACEETPLEQVTKQLNKLINVIKIIEQDEEQSVSRELALIKVRADAGTRSQVIEAVNLFRANVIDVSPESLTVEATGNRGKLEALLRVLEPFGIREIAQSGMVSLSRGPRCIGTVK
>NC_022663.1|WP_023372173.1|5173554_5175399_+|acetolactate-synthase-large-subunit
MSAPTKPHSPTSQGGENGAKPSLPQPRHVAPQQLTGAQAVIRSLEELDVDVIFGIPGGAVLPVYDPLFDSQKLRHVLVRHEQGAGHAASGYAHATGRVGVCMATSGPGATNLVTPLADAQMDSIPVVAITGQVGRGLIGTDAFQEADISGITMPITKHNFLVRSGDEIPRVIAEAFHIAASGRPGAVLVDIPKDVLQGQCTFSWPPRMDLPGYKPNTKPHNRQIRAAAKLIAAARKPVLYVGGGVIRGEATQQLRELAELTGIPVVTTLMARGAFPDSHGQNLGMPGMHGTVAAVAALQRSDLLIALGTRFDDRVTGKLDSFAPEAKVIHADIDPAEIGKNRHADVPIVADVKAVIAELIAMLRHYDIPGTLELSEWWAYLEGVRKTYPLSYGPQSDGSLSPEYVIEKLGEIAGPDAVYVAGVGQHQMWAAQFIKYEKPRTWLNSGGLGTMGFAIPAAMGAKIALPDTEVWAIDGDGCFQMTNQELATCAIEGIPIKVALINNGNLGMVRQWQSLFYEERYSQTDLATHSHRIPDFVKLAEALGCVGLRCERAEDVVDVINQARAINDCPVVIDFIVGADAQVWPMVAAGTSNDEIQAARGIRPLFDDESEGHA
>NC_022663.1|WP_042312844.1|5172875_5173283_-|PH-domain-containing-protein
MACERWNDTRVVTGSPVVIRVSPIAHLAVGFATLGLLIPVLAWPPSAPLLLIPVLLSALIVRLRTVADDDGVTVRTLLGSRTVRWDDIDGLRFHRGSWARARLKDGTELRLPAVTFSTLPQLTEASSGRIPNPYR
>NC_022663.1|WP_023372171.1|5172023_5172869_+|DoxX-family-protein
MTSSNDSHWQRPDGSPGPTAGRPVSASLVDPEDDLSPGGYSGDFGNTGTTTVIPPYDPANSGAVSSGYHLLDAQEPLPYAQPQPAGRPVPSAPAIDIDADDERVRAAGRRGTQHLGLLVLRVGLGAVLIAHGLQKLFGWWGGSGVTGFKNSLSDVGYQHADILAYVGAGGEIVAGVLLVLGLFTPLAAAGALAFLINGLLAMVSARPHSHFTYFLPDGNEYQISLVVMAVAVILSGPGRYGLDAGRGWAQRPFIGSFVALLAGIAAGIAVWVFLNGVNPLA
>NC_022663.1|WP_042313921.1|5170701_5171823_-|sorbosone-dehydrogenase-family-protein
MRIRRSVRRALTVLCAAALVSSGCARFNDAQSQPFTTNPELRPQPSSTPPPPPPLPPTPFPKACPAPGVMQGCLESTSGLIMGIDSKTALVAERITGAVKEISISAEPKVKMVIPVDPAGDGGLMDIVLSPTYSQDRLMYAYISTPTDNRVIRIADGDVPKDILTGIPKGPAGNTGALIFTSPTTLVVMTGDAGNPAMAADPNSLAGKVLRIEQPTTIGQAPPTTALTGIGSGGGMCIDPVDGSLYVADRTPGADRLQRITKKSEVSTVWTWPDKPGVAGCAAMDGTVLVNLINTKLTVAVRLAPSTGAVTGEPDVVRKDTHAHAWALRMSPDGNVWGATVNKTAGDAEKLDDVVFPLFPQGGGFPRNNDDKT
>NC_022663.1|WP_099185092.1|5170024_5170558_+|flavin-reductase
MTMLDSPAFVVTTQADGHPSGCLVGFATQTSVQPPSFMIGMPRSNRTAEVAGRSDHVAVHLLAQHHRALAELFAGHTADDTDKFARCPWRAGPFGMPILDDAVAWFVGRTVSRSDVGDHVCYLLEPVSVWAPECSEELLYLSDIDDLDPGHEEPTRRFYEPTEVTRRYGVRFTLDVP
>NC_022663.1|WP_023372180.1|5180896_5181907_+|3-isopropylmalate-dehydrogenase
MKLAIIAGDGIGPEVVAEAVKVLDAVLPGVQKTGYDLGASRFHATGELLPDTVLAELREHDAILLGAIGDPSVPSGVLERGLLLRLRFELDHHINLRPARLYPGVNSPLAGNPDIDFLVVREGTEGPYTGNGGAIRVGTPNEVATEVSVNTAFGARRVVADAFERARRRRKHLTLVHKTNVLTFAGSLWWRTVQEIAKKYPDVEVAYQHVDAATIHMITDPGRFDVIVTDNLFGDIITDLAAAVCGGIGLAASGNIDATRTNPSMFEPVHGSAPDIAGQGIADPTAAIMSVALLLAHVGEDDAAGRVDRAVEKFLATRGNQRLTTTVIGDRIVAAL
>NC_022663.1|WP_042313923.1|5181903_5183061_-|MFS-transporter
MLAVALVATLCATVFINGIAFLIPALNDVRGISLSEAALLSAMPSFGMVFTLIGWGYVLDLVGERIVLSVGLALTAAAAYGASLVPQSMLAEGIALFVGGMAAASANTASGRLVTGWFAAEQRGLAMGIRQTAQPLGIASAAVVLPELGERSISVALLFPATVCALAALLCAVWVRDPSRPARSVADHRELASPYRGTAVLWRIHLASALLMVPQTVVLTFMLVWLIHSHGWSIAAAGTLVSVSQLLGALGRIAAGRWSDHLGSRMRPIRMIAVAAALGMMLLAVADHLHSTVAVALMVVASVITVLDNGLAFTAIPEVAGRFWSGRAMGAQNTTQRLTAAVGPPVFGQVIEASGYPLAFAVCGLFPLLAWPIVPQHTRARVRTC
>NC_022663.1|WP_023372182.1|5183152_5184502_-|MFS-transporter
MPRQPSDPGELSLFARWSIVVVSLLVTASSFLFINGVAFLIPRLEAARGTPLTQAGLLASMPSWGMVVTLVAWGYVLDRVGERLVMTVGSALTAAAAYAAASVHSLTLMGVYLFLGGMAAASCNSAGGRLVSGWFPPHQRGLAMGIRQTAQPLGIALGALVIPELAEQGAHAGLMFPAVACTVAAVASLIGVADAPRKSRKVATDEELASPYRGSSVLWRIHAVSALLMMPQTVTVTFMLVWLMNHHGWSVAAAGGLVTVSQLLGALGRIAVGRWSDYVGSRMRPVRIIAIAAASALFLLALTDNIGSRYDVLLMIAIAVIAVLDNGLEATAITEFAGPYWSGRALGTQNTTQRLMAAAGPPLFGALITTAAYPLAWALCGLFPLAAVPLVPTRLLPPGLETRARRQSVRRHRWRQAVRARELPTRPRLAGPPGSSRPGRRGRAPTPPT
>NC_022663.1|WP_036391914.1|5184556_5185246_-|class-I-SAM-dependent-methyltransferase
MDWEAAYREHGVFGGPPPWNIGEPQPEIAALIRAGKIRSEVLDAGCGVAELSLALAALGHTVMGVDVSGTAIAKAKQAATDRGLSTVTFVQDDLTSLDGYDGRFNTIIDSTLFESLPVDSRDDYIRSVHRAAAPGASYYVLASTATALPADIELPPDAPAAPPNLVTETELREAVSRYWAIDEIRPAFIHVHLAEVLSRIPGVSLADYEVDERNRVKVSAFLLTAHKAG
>NC_022663.1|WP_023372184.1|5185602_5186853_-|MFS-transporter
MATEPVSAALRWSMVAIALTVTASAFSFINAVPFMIPALEAARGTALAEAGLLSAMPSLGMVVTLIAWGYVADRIGERTVLATGSALTAVSAFAAASVNSLVAMGALLFLGGMAAASCNPACGRLVAGWFPAHQRGLAMGVRQTAQPLGIAMGALVIPRLAEHRPSLGLLFPASACAVSAVVGALIAHDPPRRTPPTASGTELVNPYRGNAVLWRIHMVSALMVMPQSMTVTFMLVWLTGNHGWSVRAAGALVTITQLLGALSRIAAGRWSDGVGSRMRPVRIVALATSVTLLMLSLANQLDSPLAVAFMVMVSVVTVMDNGLEATAITEFAGQFWSGRALGVQNTTQRLMTLAGPPAFGAMITVGGYPLAFALCGLFPLAAAPLVPVGLRPPDAEDREAEHSLGRLPRKPVQARD
>NC_022663.1|WP_155254711.1|5187000_5187429_+|hypothetical-protein
MTRARSARLRRARDRLGPMTTARSARLRRARDRLGPMTTARSARLRRARDRLGPMTTARSARLRRARDRLGPMTTARSARLRRARDRLGPMTTARSARLRRARDRLGPMTTARSARLRRARDRLGPMTTARSARLRRARDRR
>NC_022663.1|WP_036391277.1|5187439_5188258_+|fumarylacetoacetate-hydrolase-family-protein
MRLGRIASPDGPSGRSAFVSIEGSLDDPGGMTVREIAEHPFGTPTFTGRSWPLADVRLLAPILASKVVCVGKNYADHIAEMGGQTGPAQADPVIFLKPNTAIIGPNVPIRLPANASPVHFEGELAVVIGRPCKDVPAAQAADNILGYTVANDVSARDQQQSDGQWTRAKGHDTFCPVGPWIVTDLDPLDPTDLELRTEVNGEVKQHARTSLMIHDTGAIVEWISAVMTLLPGDLILTGTPAGVGPIEDGDTVSITVEGIGTLTNPIVRKGKS
>NC_022663.1|WP_080674133.1|5188254_5189742_+|glutamate--tRNA-ligase
MTAAAPEEEATRVRVRFCPSPTGIPHVGMVRTALFNWAYARHTGGTFVFRIEDTDAQRDSEESYLALLDALRWLGLNWDEGPEVGGPYGPYRQSQRREIYRDVIAQLLVADEAYYAFSTPEEVEARHIAAGRNPKLGYDNFDRHLTDSQRAAYLAEGRQPVVRLRMPDTDLSWSDLVRGPTTFAAGSVPDFALTRANGDPLYTLVNPCDDALMKITHVLRGEDLLPSTPRQLALYQSLIRVGIAERVPEFAHLPTVLGEGTKKLSKRDPQSNLFAHRDRGFIPEGLLNYLALLGWSIADDRDLFSLDEMVAAFDVADVNSNPARFDQKKADALNAEHIRMLDVEDFTRRLRDYLDVHGHRIELDDAAFATAAELVQTRIVVLGDAWDLLKFLSDDQYAIDPKAAAKELGPDAAPVLDAAVAALQGVSDWIAAHIEEVLKAALIEGLELKPRKAFGPIRVAATGTTVSPPLFESLELLGRDRSLARLTSARDSVTK
>NC_022663.1|WP_023372188.1|5190128_5190641_-|PPOX-class-F420-dependent-oxidoreductase
MGSNQRAQIVMTEEEIADFVNKSRTGTLATIGPDGQPHLTAMWYAVVDGEIWLETKAKSQKAVNLKRDPRVSFLLEDGNTYDTLRGVSFEGVAEIIDEPDALFRVGVSVWERYTGPYSDELRPMVDQMMNKRVGVRIVSCRTRSWDHRKLGLPHMPVGGSTAPAVLGTGH
>NC_022663.1|WP_023372189.1|5190719_5191421_-|IclR-family-transcriptional-regulator
MRQHSGIGVLDKAVGLLHAIAESPCGLAELCDRTGLPRATAYRLAAALEVHRLLGRDEEGRWRLGPAVSELAAHVNDSLLAASNAVLPKLRETTGESVQLYRREGTTRVCVAALEPAAGLRDTVPVGARLPMTAGSGAKVLLAYSDAAIQQAVLPNAKFGERVLAEVRRRGWAQSVAEREPGVASVSAPVRDRRGVVVAAISVSGPVDRMGRRPGARWAADLVAAAEEITGRL

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Crispr_ID: NC_022663_18

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022663_18

5470303-5470389

Orphan

Consensus_repeat	Method
CCGCGCCGGCCCGCATCGTCGCCCGGCTAGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022663_18

>merge|NC_022663|18|5470303-5470389|CRISPRCasFinder
CCGCGCCGGCCCGCATCGTCGCCCGGCTAGGTCTGATGGCCGGGCTCCTCACCGGGCCGCGCCGGCCCGCATCGTCGCCCGGCTAGG

>NC_022663|18|14|5470303-5470389|CRISPRCasFinder
CCGCGCCGGCCCGCATCGTCGCCCGGCTAGG	TCTGATGGCCGGGCTCCTCACCGGG
CCGCGCCGGCCCGCATCGTCGCCCGGCTAGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_022663.1\|WP_023372418.1\|5473396_5473930_+\|ribosome-maturation-factor-RimP	unknown	unknown	gnl\|CDD\|234627
NC_022663.1\|WP_036391352.1\|5472633_5473170_-\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_023372422.1\|5478432_5478930_+\|30S-ribosome-binding-factor-RbfA	unknown	unknown	gnl\|CDD\|234787
NC_022663.1\|WP_080674273.1\|5475042_5475390_+\|YlxR-family-protein	unknown	unknown	gnl\|CDD\|225350
NC_022663.1\|WP_080674141.1\|5478853_5479918_+\|bifunctional-oligoribonuclease/PAP-phosphatase-NrnA	unknown	unknown	gnl\|CDD\|223691
NC_022663.1\|WP_041803368.1\|5457795_5459634_-\|PE-family-protein	unknown	unknown	gnl\|CDD\|376422
NC_022663.1\|WP_023372408.1\|5461352_5461823_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|225064
NC_022663.1\|WP_023372412.1\|5465881_5467117_+\|uroporphyrinogen-III-C-methyltransferase	unknown	unknown	gnl\|CDD\|381169
NC_022663.1\|WP_023372405.1\|5457207_5457615_+\|PPOX-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274925
NC_022663.1\|WP_023372416.1\|5472148_5472637_-\|ferritin-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|373114
NC_022663.1\|WP_023372421.1\|5475478_5478319_+\|translation-initiation-factor-IF-2	unknown	unknown	gnl\|CDD\|235401
NC_022663.1\|WP_023372409.1\|5461819_5463667_+\|magnesium-chelatase-subunit-D-family-protein	unknown	unknown	gnl\|CDD\|274135
NC_022663.1\|WP_023372413.1\|5467139_5468732_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NC_022663.1\|WP_023372411.1\|5464328_5465702_+\|cobyrinate-a,c-diamide-synthase	unknown	unknown	gnl\|CDD\|234896
NC_022663.1\|WP_023372410.1\|5463700_5464324_+\|cob(I)yrinic-acid-a,c-diamide-adenosyltransferase	unknown	unknown	gnl\|CDD\|235662
NC_022663.1\|WP_023372419.1\|5473926_5474970_+\|transcription-termination/antitermination-protein-NusA	unknown	unknown	gnl\|CDD\|237061
NC_022663.1\|WP_023372414.1\|5468744_5470031_-\|sterol-desaturase-family-protein	unknown	unknown	gnl\|CDD\|225546
NC_022663.1\|WP_023372415.1\|5470399_5472148_+\|proline--tRNA-ligase	unknown	unknown	gnl\|CDD\|236405
NC_022663.1\|WP_036391350.1\|5459871_5461356_+\|malate-dehydrogenase-(quinone)	unknown	unknown	gnl\|CDD\|377591
NC_022663.1\|WP_036444400.1\|5479924_5481247_+\|MATE-family-efflux-transporter	unknown	unknown	gnl\|CDD\|240541

Protein	Function_ID	Function_description	E-value
NC_022663.1\|WP_023372418.1\|5473396_5473930_+\|ribosome-maturation-factor-RimP	gnl\|CDD\|234627	PRK00092, PRK00092, ribosome maturation protein RimP; Reviewed.	7.08189e-48
NC_022663.1\|WP_023372422.1\|5478432_5478930_+\|30S-ribosome-binding-factor-RbfA	gnl\|CDD\|234787	PRK00521, rbfA, 30S ribosome-binding factor RbfA.	6.12872e-44
NC_022663.1\|WP_080674273.1\|5475042_5475390_+\|YlxR-family-protein	gnl\|CDD\|225350	COG2740, COG2740, Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription].	6.77167e-23
NC_022663.1\|WP_080674141.1\|5478853_5479918_+\|bifunctional-oligoribonuclease/PAP-phosphatase-NrnA	gnl\|CDD\|223691	COG0618, COG0618, Exopolyphosphatase-related proteins [General function prediction only].	6.93942e-75
NC_022663.1\|WP_041803368.1\|5457795_5459634_-\|PE-family-protein	gnl\|CDD\|376422	pfam00934, PE, PE family. This family named after a PE motif near to the amino terminus of the domain. The PE family of proteins all contain an amino-terminal region of about 110 amino acids. The carboxyl terminus of this family are variable and fall into several classes. The largest class of PE proteins is the highly repetitive PGRS class which have a high glycine content. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	7.05792e-31
NC_022663.1\|WP_023372408.1\|5461352_5461823_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|225064	COG2153, ElaA, Predicted acyltransferase [General function prediction only].	2.77483e-70
NC_022663.1\|WP_023372412.1\|5465881_5467117_+\|uroporphyrinogen-III-C-methyltransferase	gnl\|CDD\|381169	cd11642, SUMT, Uroporphyrin-III C-methyltransferase (also known as S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT). SUMT is an enzyme of the cobalamin and siroheme biosynthetic pathway. It catalyzes the first of three steps leading to the formation of siroheme from uroporphyrinogen III; it transfers two methyl groups from S-adenosyl-L-methionine to the C-2 and C-7 atoms of uroporphyrinogen III to yield precorrin-2 via the intermediate formation of precorrin-1. Precorrin-2 is also a precursor for the biosynthesis of vitamin B12, coenzyme F430, siroheme and heme d1. This family includes proteins in which the SUMT domain is fused to other functional domains, such as to a uroporphyrinogen-III synthase domain to form bifunctional uroporphyrinogen-III methylase/uroporphyrinogen-III synthase, or to a dual function dehydrogenase-chelatase domain, as in the case of the multifunctional S-adenosyl-L-methionine (SAM)-dependent bismethyltransferase/dehydrogenase/ferrochelatase CysG, which catalyzes all three steps that transform uroporphyrinogen III into siroheme.	1.84918e-101
NC_022663.1\|WP_023372405.1\|5457207_5457615_+\|PPOX-class-F420-dependent-oxidoreductase	gnl\|CDD\|274925	TIGR04023, Pyridoxamine_5'-phosphate_oxidase, PPOX class F420-dependent enzyme, MSMEG_5819/OxyR family. A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomycetales, make F420. This subfamily within the PPOX family occurs in at least 19 distinct species of F420 producers and is likely to bind F420 rather than FMN. The member OxyR was shown to use F420 to catalyze a C5a-C11a reduction in oxytetracycline biosynthesis. [Unknown function, Enzymes of unknown specificity].	1.04499e-56
NC_022663.1\|WP_023372416.1\|5472148_5472637_-\|ferritin-like-domain-containing-protein	gnl\|CDD\|373114	pfam14530, DUF4439, Domain of unknown function (DUF4439). This domain has a ferritin-like fold.	4.0315e-36
NC_022663.1\|WP_023372421.1\|5475478_5478319_+\|translation-initiation-factor-IF-2	gnl\|CDD\|235401	PRK05306, infB, translation initiation factor IF-2; Validated.	0
NC_022663.1\|WP_023372409.1\|5461819_5463667_+\|magnesium-chelatase-subunit-D-family-protein	gnl\|CDD\|274135	TIGR02442, Uncharacterized_protein_Rv2850c/MT2916, cobaltochelatase subunit. Cobaltochelatase is responsible for the insertion of cobalt into the corrin ring of coenzyme B12 during its biosynthesis. Two versions have been well described. CbiK/CbiX is a monomeric, anaerobic version which acts early in the biosynthesis (pfam06180). CobNST is a trimeric, ATP-dependent, aerobic version which acts late in the biosynthesis (TIGR02257/TIGR01650/TIGR01651). A number of genomes (actinobacteria, cyanobacteria, betaproteobacteria and pseudomonads) which apparently biosynthesize B12, encode a cobN gene but are demonstrably lacking cobS and cobT. These genomes do, however contain a homolog (modelled here) of the magnesium chelatase subunits BchI/BchD family. Aside from the cyanobacteria (which have a separate magnesium chelatase trimer), these species do not make chlorins, so do not have any use for a magnesium chelatase. Furthermore, in nearly all cases the members of this family are proximal to either CobN itself or other genes involved in cobalt transport or B12 biosynthesis.	0
NC_022663.1\|WP_023372413.1\|5467139_5468732_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	6.06232e-52
NC_022663.1\|WP_023372411.1\|5464328_5465702_+\|cobyrinate-a,c-diamide-synthase	gnl\|CDD\|234896	PRK01077, PRK01077, cobyrinate a,c-diamide synthase.	0
NC_022663.1\|WP_023372410.1\|5463700_5464324_+\|cob(I)yrinic-acid-a,c-diamide-adenosyltransferase	gnl\|CDD\|235662	PRK05986, PRK05986, cob(I)yrinic acid a,c-diamide adenosyltransferase.	1.86067e-109
NC_022663.1\|WP_023372419.1\|5473926_5474970_+\|transcription-termination/antitermination-protein-NusA	gnl\|CDD\|237061	PRK12327, nusA, transcription elongation factor NusA; Provisional.	0
NC_022663.1\|WP_023372414.1\|5468744_5470031_-\|sterol-desaturase-family-protein	gnl\|CDD\|225546	COG3000, ERG3, Sterol desaturase [Lipid metabolism].	1.48494e-34
NC_022663.1\|WP_023372415.1\|5470399_5472148_+\|proline--tRNA-ligase	gnl\|CDD\|236405	PRK09194, PRK09194, prolyl-tRNA synthetase; Provisional.	0
NC_022663.1\|WP_036391350.1\|5459871_5461356_+\|malate-dehydrogenase-(quinone)	gnl\|CDD\|377591	pfam06039, Mqo, Malate:quinone oxidoreductase (Mqo). This family consists of several bacterial Malate:quinone oxidoreductase (Mqo) proteins (EC:1.1.99.16). Mqo takes part in the citric acid cycle. It oxidizes L-malate to oxaloacetate and donates electrons to ubiquinone-1 and other artificial acceptors or, via the electron transfer chain, to oxygen. NAD is not an acceptor and the natural direct acceptor for the enzyme is most likely a quinone. The enzyme is therefore called malate:quinone oxidoreductase, abbreviated to Mqo. Mqo is a peripheral membrane protein and can be released from the membrane by addition of chelators.	0
NC_022663.1\|WP_036444400.1\|5479924_5481247_+\|MATE-family-efflux-transporter	gnl\|CDD\|240541	cd13136, MATE_DinF_like, DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	4.73532e-89

>NC_022663.1|WP_023372414.1|5468744_5470031_-|sterol-desaturase-family-protein
MNAALTRAEPEYRDGPVLAALGILYSAELIGLAGAAAFVTKGGHEHLDRGTTVLAVILVAAAAMAGWHAIRLLQGARVLKVTGLALQSALLITAIAIATVRPILGVPAVIVSAGVLVGWGRLARIGWRLAVADRPDLVASTATSASVGPAAARGSGGVSPGGIALVLVTSTLVLVALSMRGEMAVKLAILAIIFIPLERLFALRPLHVLRRGWRTDVVHYLVNGAARKVGLVGAVAVVGTVLQVLVPAAFRGNVAAASGWVQIVAALGITAVGGYAGHRAMHEVPVLWRFHRVHHSVREMDWLAAGHMHPLDQIAIRSAAVVPLYALGFGRVSLGAIVILLTVQDIFIHANLRMTCGPLRWLIATPQFHHWHHARQPQAYNTNYAAEFPIVDALFGTLYLPTGRWPAEYGIDDDQPDGYLRQLVWPLR
>NC_022663.1|WP_023372413.1|5467139_5468732_+|MFS-transporter
MTALNDTERAAHNWTSGRQERPASARPARSAETASQRITRYYPTWLPSRRFIAAVIAIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWVITAYVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEATMVIARLSQGVGSAIASPTGLALVATTFPKGPARNAATAVFAAMTAIGSVMGLVVGGALTEVSWRLAFLVNVPIGLVMIYLARTALRETNRERMKLDAAGAMLATLACTAAVFAFSMGPEKGWISVTTIGSGAVALAAVLAFIVVERTAENPVVPFHLFRDRNRLVTFIAIFLAGGVMFTLTVSIGLYVQDILGYSALRAGVGFIPFVIAMGIGLGISSQLVSRFSPRVLTIAGGYLLVLAMLYGWLFMHRGVAYFPNLVVPIVVGGVGIGMAVVPLTLSAIAGVGFDQIGPVSAMTLMLQSLGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDAQLAALDHGYTYGLLWIAGAAVIVGGAAVLIGYTPAQVAHAQEVKEAIDAGEL
>NC_022663.1|WP_023372412.1|5465881_5467117_+|uroporphyrinogen-III-C-methyltransferase
MTESPYLVGLRMAGKKVVVVGGGSVAQRRLPLLISSGADVHVITRSATRAVEAMEGITLSLREYRDGDLEGAWYAIAATDDAEVNATVVAEADSRQIFCVRADVAVEGSAVTPATFSYAGLSVGVLAGGEHRRSAAIRSAIREALQTGLITPESPEGPVSSDVVHGGVALVGGGPGDPELITVRGRRLLAHADVVIADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAIHAAMIERAKSGSFVVRLKGGDPFVFARGYEEVLACADAGIPVTVVPGVTSAIAVPASAGVPVTHRATNHEFVVVSGHLPPGHPESLVNWNALAALSGTIVLLMAVERIELFVDALLKGGRPAKTPVLVVQQGTTPAQHTLRATLADTPEKVRAEGIRPPAIVVIGAVAGLGGVRGLNDS
>NC_022663.1|WP_023372411.1|5464328_5465702_+|cobyrinate-a,c-diamide-synthase
MTSTPALVIAAPASGSGKTTVATGLMGALCQGGHRVAPFKVGPDFIDPGYHTLASRRVGRNLDPVLVGEQLIGPLYAHGTVGADIAVIEGVMGLFDGRIDEAVSGPAAGSTAHVAGLLGAPVVLVVDARGQSHSVAALLHGFTTFDSATRIAGVILNRVGTARHEHVLRQACEQAGVPVLGAIPRTAELELPTRYLGLVTAVEYGRRARLAVEAMTALVARHIDLSAIVAAAASRVGAPPWDPVTAVGGPVGGRPTVAMAAGKAFSFAYAEHAELLRAVGADVVEFDPLTQALPEGTNAVLLPGGFPEQFAAELSANELVRGQLQHMAAAGVPVHAECAGLIYLVSELDGYPMCGVLAGSARFTQRLTLGYRDAVAVADSPLYSVGRRVAGHEFHRTTVTFTDSYQPAWVYRSRGHDDHPLRDGVVHGGVHASYLHTHPAATPEAVARFVAHASARS
>NC_022663.1|WP_023372410.1|5463700_5464324_+|cob(I)yrinic-acid-a,c-diamide-adenosyltransferase
MPQGNPTYIPDDGLTTRARRNLPVLAIHTGDGKGKSTAAFGMALRAWNVGLDVAVFQFVKSAKWKVGEEAALHQLGRLHDEQGIGGAVEWHKMGAGWSWTRKSRKTGSEVDHAAAAADGWAEIARRLAEERHQFYVLDEFTYPLKWGWLDVDDVVEVLLARPGHQHVVITGRDAPPRLIEAADLVTEMTKVKHPMDVGRKGQQGIEW
>NC_022663.1|WP_023372409.1|5461819_5463667_+|magnesium-chelatase-subunit-D-family-protein
MKPYPFSAIVGHDQMRLALLLCAVRPEIGGVLIRGEKGTAKSTAVRGLAALLSIVTGGGGAGLVEMPLGATEDRVVGSLDLQRVLREGEHAFSPGLLARAHGGVLYVDEVNLLHDHLVDILLDAAAMGRVHVERDGVSHSHDARFVLIGTMNPEEGELRPQLLDRFGLTVDVQASRDVDVRVEVIRQRMAYEADPDTFAERYASADAALANRIAAARGSVDDVLLPDNELRRIAALCAAFDVDGMRADLVVARTAAAHAAWRGAGVVEEQDIRVAAELALPHRRRRDPFDDHGLDRDQLNEALALGAPPAGGGAGSDPEPEPDPPGGGQSTNNSVFQSNSHAAPTPPKPSAPPSNMFRTRALTVPGVGEGAPGRRSRARNASGSVVAAAEAGAPAGHGLHLFATLLAAAEHASGAGPLRPQADDVRRAVREGREGNLVIFVVDASGSMAARDRLAAVSGATMSLLRDAYQRRDKVAVITFRQHEAGLLLPPTSSAHIAGRRLARFDTGGKTPLAEGLLAARELVIREKARDLARRALVVVLTDGRATSGPDPLGRSRIAASRLAAEGVAAVVVDCETSYVRLGLAGQLARQLGAPAVRLEQLHAEHLTRAVRNVA
>NC_022663.1|WP_023372408.1|5461352_5461823_+|GNAT-family-N-acetyltransferase
MTEALRRVWAKDLDAAALYELLKLRVEVFVVEQACPYPELDGRDLLAETRHFWLENPDGEVICTLRLMEEHAGGEKTFRIGRLCTRRDARGQGHTTRLLRAALAEVGDYPCRIDAQVYLADMYAQHGFVRDGDDFIDDGIPHVPMLRPASGRTAHS
>NC_022663.1|WP_036391350.1|5459871_5461356_+|malate-dehydrogenase-(quinone)
MSELTRTADVVLVGAGIMSATLAALLKRLEPDWSITVVERLDTVAAESSSPWNNAGTGHAALCELNYTPENFDGSINVSKAVRIAEQFQVTRQFWAYAVENAILGDVRSFLNPVPHVSFVHGADRVDYLRRRHAALASNPLFSAIELIDDPDEFVRRLPFMGAKRDFSEPVALNWASGGTDVDFGALSRQLIGFCVRNGATALFGHEVRQLSRQSDGSWTLTVTNRRAGQKHKLNAKFVFIGAGGDALPLLQKSGIREIKGFAGFPIGGRFLRTDNPVLTAAHRAKVYGVPSPGAPPLGALHLDLRFVNGKSWLVFGPYAGWSPKFLKQGHFSDLPRSIKPNNVLSMLGVGFTQMTLLNYLVSQLRLSAPDRVDALREFAPSAVDSDWNLLVAGQRVQVIRRDKRKGGVLDFGTTIVGDADGSIVGLLGGSPGASTAVPIMLEVLERCFAHRYQSWLPTLKEMVPSLGARLSAEPALYNEVWSWTTKALQLDIP
>NC_022663.1|WP_041803368.1|5457795_5459634_-|PE-family-protein
MLFVIATPEILTAASSDLAAVGSAVMAANTAAAVPTTRLLAAAQDEVSAAIAALFGAHAQEYQAISAQAAAFHDQFVRALTASGGSYAMAEAANASPFQTVLDAVNAPTQALLGRPLIGNGADGSAPGQAGAPGGLLYGNGGNGAAGGPNQAGGAGGNAGLIGHGGAGGVGGAGAVGGNGGTGGLLFGNGGAGGHGGPGVAGVNGGNAGQGGHGGNAYLFGDGGAGGQGGTGATGIAGSNPTPLGTAAPGSDGANQIMNTSSNLTGGAGEDGKAGGVTVAGGNGGNGGVARNVFGNGDVTGGAAGDGGNGAHGGNGGVGGEASTGGATAVSGSGGNGGNAEAAGGAGGNGGRGGFAQATSSVAGGNGGNGGNGHDTDVSGGAGGAGGVGGDGGRGGLLAGNGGGGGRGGTGGIGGAGAPGGAGGGGGKADMANSIGPNATVTAGDGGTGGDGGSALGTGGAGGAGGLGGHGGAGGLLFGNGGAGGAGGIGGAGGEGGAGGGGGAGGAGGEAIPGDVNTNSFGGDGGNGGSGGNGGSGGGGGAPGLGGTGGTGGWLIGQAGSTGAGGAGGAGGAGGAGGTAGDGGPAGGGDTSDGKAGLSGVDGFNGNTGQHG
>NC_022663.1|WP_023372405.1|5457207_5457615_+|PPOX-class-F420-dependent-oxidoreductase
MTVFTDVEIEYLASQRLGRLATLAPKGSPQVRPVRFQYNAELDTIDIGGRAMAGSRKLRNVENDPRVSFVIDDLASIDPWRPRGIEIRGRAEALPVDGAQEGSGGALIRIHPRRIVVWGLDSESPALHARNVTKD
>NC_022663.1|WP_023372415.1|5470399_5472148_+|proline--tRNA-ligase
MITRMSQLFLRTLRDDPADAEVPSHKLLIRAGYVRPIAPGLYSWLPLGLRVLRNIERVVREEMNAIGGQEILFPALLPRAPYETTNRWTEYGDSVFRLQDRRGNDYLLGPTHEELFTLTVKGEYNSYKDFPLVLYQIQNKYRDEARPRAGILRVREFVMKDSYSFDIDSAGLKAAYHAHREAYQRIFERLRVRYVIVSAVSGAMGGSASEEFLAESPVGEDTFVRCPESGYAANVEAVITARPETRPIDGQPEAVVHDTGDTPTIATLVEWANQADLGRTVTAADTLKNVLVKVRQPGKDWELLAIGVPGDREVDDKRLSAALEPAEYALLDDNDFARYPFLVKGYIGPKALHANNIRYLVDPRVVDGSSWITGADEPGRHVVGLVAGRDFTADGTIEAAEVREGDPSPDGAGSLVMARGIEIGHIFQLGQKYTDAFSADVLGEDGKPVRLTMGSYGIGVSRLVAVVAEQHHDELGLRWPPAIAPFDVHLVIANKDAEARTGAVALATELNQQGVEVLLDDRQASPGVKFKDAELLGMPWIVVVGRGWADGVVELRDRFSGQTRELAAGASLATDIAAVISG
>NC_022663.1|WP_023372416.1|5472148_5472637_-|ferritin-like-domain-containing-protein
MTSSEPSFGASPKRSPAGKDADTAALSDALAVEHATIYGYGIVSALSPPSVNDLVVEALNQHRQRRDDVIAMLAARKVTAPAAAPGYQLPNDVGSAADAARLAARMENDGATAWRAVVEHAETADDRAFASTALTQSAVMAARWNKVLGAWPITASFPGGNE
>NC_022663.1|WP_036391352.1|5472633_5473170_-|hypothetical-protein
MPRAVPVVNRRGVLAGGAALAALGVVVSACGESTPKPPAVDELLAPLEQARRDSALASAAAAAIGNPPQIAAALTVVASQRGAHARALATEIARAAGKLVSATSETSSSSASPSPTDTEPPPPPPPVSDVVDSLRKSAEDASRLVATVSGYRAGLLASIAASCTASYTVALMPGGPSI
>NC_022663.1|WP_023372418.1|5473396_5473930_+|ribosome-maturation-factor-RimP
MTTGLPSQTQVIELLGGAFACAGYEIEDVVIDTRAHPPRITVVADGDTALDLDTIAALSRSASALLDGLDAIRDKYVLEVSSPGVERPLTSEKHFRRARGRKIELTLADGSRLTGRVGELTGDTLALVIRQGRNWAVRQIPLAQVLKAVVQVEFSPPARAELELATAAGATGTEAES
>NC_022663.1|WP_023372419.1|5473926_5474970_+|transcription-termination/antitermination-protein-NusA
MNIDMAALHAIEVDRGISVNELLETIKSALLSAYRHTQGHQTDARIEIDRKSGVVRVIARELDDEGNLISEWDDTPEGFGRIAATTARQVMLQRFRDAENERTYGEFSTREGEIVAGVIQRDSRANARGLVVVRMGSETKASEGVIPAAEQVPGESYEHGNRLRCYVVGVSRGAREPLITLSRTHPNLVRKLFSLEVPEIADGSVEIVAVAREAGHRSKIAVRSNVPGLNAKGACIGPMGQRVRNVMSELSGEKIDIIDYDEDPARFVANALSPAKVVSVSVIDQNARAARVVVPDFQLSLAIGKEGQNARLAARLTGWRIDIRGDSPAHPAGQPEQGASRGMAHDR
>NC_022663.1|WP_080674273.1|5475042_5475390_+|YlxR-family-protein
MIQREPSVAAHRCSDSPSGPVRTCVGCRKRELAVELLRVVAESTGNGNYAVIVDPSRRLQGRGAWLHPEPRCLQQAIRRRAFTRALRITGSPDTSAVVEHISGFSTEQQNRQQRT
>NC_022663.1|WP_023372421.1|5475478_5478319_+|translation-initiation-factor-IF-2
MAGKARVHELAKELGVTSKEVLARLSEQGEFVKSASSTVEAPVARRLRESFGGAKPAPEQAPAKGPEKGPDRAAAKATAAAPGTDGGKAADQSLDQALDKAIAKAAGNGAPTAVAPDRAADSGKTATSPTRATPRPSAATATPAPPKAPQPGQPTTSLPGQPPSPPAPHPGMAPGARPGPAPKPGVRTPRVGNNPFSSAQPAERPIPRPPAPRPGAPRPGAPRPGASPGSMPPRPGGAAGGPRPPRTGAPRPGGGRPGGPGGRSDGGGGNYRGGGAGVGAAPGTGFRGRPGGGGGGPGGGGRPGQRGGAAGAFGRPGGAPRRGRKSKRQKRQEYDSMQAPVVGGVRLPHGNGETIRLARGASLSDFAEKIDANPAALVQALFNLGEMVTATQSVGDETLELLGSEMNYNVQVVSPEDEDRELLESFDLSYGEDTGDEADLQTRPPVVTVMGHVDHGKTRLLDTIRKANVREGEAGGITQHIGAYQVGVDLDGSERLITFIDTPGHEAFTAMRARGAKATDIAILVVAADDGVMPQTVEAINHAQAADVPIVVAVNKIDKEGADPAKIRAQLTEYGLVAEDFGGDTMFVDISAKNGTNIEQLLEAVLLTADAALDLRANPDMEAQGVAIEAHLDRGRGPVATVLVQRGTLRVGDSVVAGDAYGRVRRMVDEHGDDIEAALPSRPVQVIGFTSVPGAGDNFLVVDEDRIARQIADRRSARKRNAMAARSRKRISLEDLDSALKETSQLNLILKGDNAGTVEALEEALMGIQVDDEVALRVIDRGVGGITETNVNLASASDAIIIGFNVRAEGKATELANREGVEIRYYSVIYQAIDEIEAALRGMLKPIYEEVELGRAEIRALFRSSKVGLIAGCMITSGVVRRNAKARLLRDNIVVAENLSIQSLRREKDDVTEVREGFECGLTLGYSDIKEGDVIESYELVQKERS
>NC_022663.1|WP_023372422.1|5478432_5478930_+|30S-ribosome-binding-factor-RbfA
MADPARARRLAKRITTIVASAIEYEIKDPGLAGVTITDAKVTADLHDATVYYTVMGPTLDDEPDYAAAAAALDRAKGVLRTKVGAGTGVRFTPTLTFTRDTTSDTVHRMEELLARARAADADLARVRQGAKPAGDADPYRDGGASGELSDRIEAGDTGDHDRSRD
>NC_022663.1|WP_080674141.1|5478853_5479918_+|bifunctional-oligoribonuclease/PAP-phosphatase-NrnA
MAGLPGNLAIGSRLGTPVTTTDRETELAEVPTCPGARVDALGAVEMLSAAASVAVIAHVHPDADAIGAGLALALVLDKCGKQVEVSFGAPATLPESLASLPGCHLLVNPDAMRRDVDLAVTVDVPSVRRLGGLSDLAGPGRDVLVIDHHASNDAFGTANFIDLSADSTTMMIADLLDAWGKPIETDVAQCIYAGLTTDTGSFRWASARGYRLAARLVEIGVDNAAVSRTLMDTHPFEWLPMLSRVLGSAQLVPGAVAGRGLVYVVVDNREFLRARQEEVESIVDIVRTTQQAEVAAVLKEVEPRQWSVSMRAKRDMDLTPVAARFGGGGHRLAAGYSTSGSIDDVVASLLAALG
>NC_022663.1|WP_036444400.1|5479924_5481247_+|MATE-family-efflux-transporter
MSGAGRSRVPGRRIAALALPALGVLAAEPLYLLFDTAVVGRLGALSLAGLAIGSLVLGLVGSQATFLSYGTTARSARHFGAGDRAAAVVEGVQATWLAAGLGVATIVVVEAAAVPLVSAIAGSSAITEAALPWLRIAILGVPAILVSLAGNGWMRGVQDTMRPLRYVVAGFGLSALLCPLLVYGWLGMPRLGLSGSAVANLVGQWLAALLFGGALLAERVLLRVDWPVLRAQLVMARDLIVRGLAFQACFVSAAAVAARFGAAALAAHQVVLQLWGFLALVLDSLAIAAQALVGAALGAGDVSHAKSVAWRVTVFSLLAAGVLAAALGVGAPLLPSLFTHDRSVLAAIAVPWWFLVAQLPFAGIVFALDGVLLGAGDAAFMRTATVVSALIGFLPLTWLSLVYGWGLAGIWSGLATFVALRLLFVGWRTISGRWALTGAA

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Crispr_ID: NC_022663_19

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022663_19

5936341-5936417

Orphan

Consensus_repeat	Method
GATCATGTGCGCCGCTCCTTCTCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022663_19

>merge|NC_022663|19|5936341-5936417|CRISPRCasFinder
GATCATGTGCGCCGCTCCTTCTCACTGCTTCGCAGTGCATCGTCGCCGGCGCGGATCATGTGCGCCGCTCCTTTTCA

>NC_022663|19|15|5936341-5936417|CRISPRCasFinder
GATCATGTGCGCCGCTCCTTCTCA	CTGCTTCGCAGTGCATCGTCGCCGGCGCG
GATCATGTGCGCCGCTCCTTTTCA

Protein	Signature genes	Signature genes Name	Protein_function
NC_022663.1\|WP_023373271.1\|5934249_5934648_-\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_129111742.1\|5949929_5950256_-\|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl\|CDD\|274862
NC_022663.1\|WP_036391473.1\|5929625_5929859_-\|preprotein-translocase-subunit-SecG	unknown	unknown	gnl\|CDD\|235881
NC_022663.1\|WP_023373281.1\|5939128_5941219_-\|transketolase	unknown	unknown	gnl\|CDD\|223100
NC_022663.1\|WP_036391476.1\|5932761_5934114_-\|PE-family-protein	unknown	unknown	gnl\|CDD\|376422
NC_022663.1\|WP_023373253.1\|5921910_5923119_-\|PPE-family-protein	unknown	unknown	gnl\|CDD\|366325
NC_022663.1\|WP_023373279.1\|5937995_5939114_-\|transaldolase	unknown	unknown	gnl\|CDD\|235117
NC_022663.1\|WP_023373277.1\|5936448_5937999_-\|glucose-6-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|235579
NC_022663.1\|WP_023373294.1\|5949636_5949927_-\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_023373292.1\|5948512_5949640_+\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_023373259.1\|5925893_5926676_-\|FAD-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|224238
NC_022663.1\|WP_023373257.1\|5924173_5925880_+\|FUSC-family-protein	unknown	unknown	gnl\|CDD\|130728
NC_022663.1\|WP_133163590.1\|5946467_5947049_-\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_169733145.1\|5947099_5948428_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|373990
NC_022663.1\|WP_023373261.1\|5926672_5927179_-\|(2Fe-2S)-binding-protein	unknown	unknown	gnl\|CDD\|224991
NC_022663.1\|WP_099318754.1\|5941512_5942496_+\|protoheme-IX-farnesyltransferase	unknown	unknown	gnl\|CDD\|235293
NC_022663.1\|WP_036392218.1\|5929946_5932748_+\|phosphoenolpyruvate-carboxylase	unknown	unknown	gnl\|CDD\|234570
NC_022663.1\|WP_023373273.1\|5934697_5935438_-\|6-phosphogluconolactonase	unknown	unknown	gnl\|CDD\|376480
NC_022663.1\|WP_023373285.1\|5942674_5946388_+\|trehalose-phosphatase	unknown	unknown	gnl\|CDD\|224471
NC_022663.1\|WP_023373263.1\|5927165_5929529_-\|xanthine-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|224446

Protein	Function_ID	Function_description	E-value
NC_022663.1\|WP_129111742.1\|5949929_5950256_-\|WXG100-family-type-VII-secretion-target	gnl\|CDD\|274862	TIGR03930, WXG100_ESAT6, WXG100 family type VII secretion target. Members of this protein family include secretion targets for the two main variants of type VII secretion systems (T7SS), one found in the Actinobacteria, one found in the Firmicutes. This model was derived through iteration from pfam06013. The best characterized member of this family is ESAT-6 from Mycobacterium tuberculosis. Members of this family usually are ~100 amino acids in length but occasionally have a long C-terminal extension.	1.67864e-10
NC_022663.1\|WP_036391473.1\|5929625_5929859_-\|preprotein-translocase-subunit-SecG	gnl\|CDD\|235881	PRK06870, secG, preprotein translocase subunit SecG; Reviewed.	6.59866e-13
NC_022663.1\|WP_023373281.1\|5939128_5941219_-\|transketolase	gnl\|CDD\|223100	COG0021, TktA, Transketolase [Carbohydrate transport and metabolism].	0
NC_022663.1\|WP_036391476.1\|5932761_5934114_-\|PE-family-protein	gnl\|CDD\|376422	pfam00934, PE, PE family. This family named after a PE motif near to the amino terminus of the domain. The PE family of proteins all contain an amino-terminal region of about 110 amino acids. The carboxyl terminus of this family are variable and fall into several classes. The largest class of PE proteins is the highly repetitive PGRS class which have a high glycine content. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	1.38056e-31
NC_022663.1\|WP_023373253.1\|5921910_5923119_-\|PPE-family-protein	gnl\|CDD\|366325	pfam00823, PPE, PPE family. This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	9.17132e-56
NC_022663.1\|WP_023373279.1\|5937995_5939114_-\|transaldolase	gnl\|CDD\|235117	PRK03343, PRK03343, transaldolase; Validated.	0
NC_022663.1\|WP_023373277.1\|5936448_5937999_-\|glucose-6-phosphate-dehydrogenase	gnl\|CDD\|235579	PRK05722, PRK05722, glucose-6-phosphate 1-dehydrogenase; Validated.	0
NC_022663.1\|WP_023373259.1\|5925893_5926676_-\|FAD-binding-domain-containing-protein	gnl\|CDD\|224238	COG1319, CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion].	7.99752e-55
NC_022663.1\|WP_023373257.1\|5924173_5925880_+\|FUSC-family-protein	gnl\|CDD\|130728	TIGR01667, Uncharacterized_protein_HI_1680, integral membrane protein, YccS/YhfK family. This model represents two clades of putative transmembrane proteins including the E. coli YccS and YhfK proteins. The YccS hypothetical equivalog (TIGR01666) is found in beta and gamma proteobacteria, while the smaller YhfK group is only found in E. coli, Salmonella and Yersinia. TMHMM on the 19 hits to this model shows a consensus of 11 transmembrane helices separated into two clusters, an N-terminal cluster of 6 and a central cluster of 5. This would indicate two non-membrane domains one on each side of the membrane.	9.05953e-14
NC_022663.1\|WP_169733145.1\|5947099_5948428_-\|hypothetical-protein	gnl\|CDD\|373990	pfam15649, Tox-REase-7, Restriction endonuclease fold toxin 7. A predicted toxin of the restriction endonuclease fold present in bacterial polymorphic toxin systems. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 5, type 6, or type 7 secretion system.	5.99042e-17
NC_022663.1\|WP_023373261.1\|5926672_5927179_-\|(2Fe-2S)-binding-protein	gnl\|CDD\|224991	COG2080, CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion].	3.44607e-62
NC_022663.1\|WP_099318754.1\|5941512_5942496_+\|protoheme-IX-farnesyltransferase	gnl\|CDD\|235293	PRK04375, PRK04375, protoheme IX farnesyltransferase; Provisional.	2.98786e-138
NC_022663.1\|WP_036392218.1\|5929946_5932748_+\|phosphoenolpyruvate-carboxylase	gnl\|CDD\|234570	PRK00009, PRK00009, phosphoenolpyruvate carboxylase; Reviewed.	0
NC_022663.1\|WP_023373273.1\|5934697_5935438_-\|6-phosphogluconolactonase	gnl\|CDD\|376480	pfam01182, Glucosamine_iso, Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase.	6.27508e-94
NC_022663.1\|WP_023373285.1\|5942674_5946388_+\|trehalose-phosphatase	gnl\|CDD\|224471	COG1554, ATH1, Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism].	0
NC_022663.1\|WP_023373263.1\|5927165_5929529_-\|xanthine-dehydrogenase-family-protein	gnl\|CDD\|224446	COG1529, CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion].	1.22267e-146

>NC_022663.1|WP_023373273.1|5934697_5935438_-|6-phosphogluconolactonase
MNLDVQTFPDSENLVEAAGQRLIQAIDNAVAARGQALIVLTGGGNGIALLRYLGASGPRIDWSKIHLFWGDERYVSEEDDERNDKQARAALLDHVDIPPGQVHPMAASDGEFGTDLDAAALAYEQVLAANAALGERAPNFDVHLLGMGPEGHVNSLFPHTAAVRETTRLVVPVEDSPKPPPQRITLTLPAIQRSREVWLIVSGRAKAEAVAAAIGGADPVAVPAAGAVGRESTLWLLDEEAAAKLG
>NC_022663.1|WP_023373271.1|5934249_5934648_-|hypothetical-protein
MTIMADRSVRSGPERSRIKTLTQAALNADKTVEQVEDVLEGLDKTMKELNSSLTALNTTVERLEGGLDHLEGTLSSLDDLAKRLIVLVEPIEAIVDRIDYIVSLGETVMSPLSVTEHAVRGVLDRLRNRAVR
>NC_022663.1|WP_036391476.1|5932761_5934114_-|PE-family-protein
MAGVLVAPEILTATAADLAGIGSTLEAANRAAAASTSRVLAAGADEVSEAIADLLSGYARQYQALSTSMAGFHQQFVQTLASGGGSYAAAETTNAAPLQTLEQQVLAVINAPTQTLLGRPLIGTGADGAPGRNGGDGGLLWGDGGNGGAGTADHPTGGNGGNAGLIGNGGNGGAGYSPAGVTGAAGGAGGVGGRGGWLFGNGGAGGNGGAGASGISGPPHATAGPGGDGGNGGAGGAAGLWGTGGAGGTGGQAGTGGRGFVGPVNGDGGNGGDGGNGGLGGAGGWLYGDGGAGGNGGMGGNGGPGGFSVVTGQPGDSGNGGNGGTGAGGGPGGWLYGNGGTGGAGGNGGAGGLPVRTGAGGDGGIGGDGATGGRGGFLTGNGGSGGAGGSGGHGNGDGTDGAGGDGGDGGDAVFIGNGGNGGPGGAGEPDGNGGAGGAGGQLFGGSGSPG
>NC_022663.1|WP_036392218.1|5929946_5932748_+|phosphoenolpyruvate-carboxylase
MVSDAALEPIGDVHRTRLGREATEPMRADIRLLGSILGDTVREQNGDEIFELVERARVEAFRVRRSEIDRTEMARMFDGIDIHRALPVIRAFSHFALLANVAEDIHRERRRAGHIAAGEPPQDSSLAATYLKLEAAELDSVTVADALKGALVSPVITAHPTEIRRRTIFITQHRITELMRLHAEGHSETDDGRSIELELRRQVLTLWQTALIRLSRLQISDEIAVGLRLYRSAFFKVVPQVNAEVRGALRDRWPDAELLSEPILKPGSWIGGDRDGNPNVTAEVVRLATGSAAYTALSHYLAELDQLEQELSMSSRLLTVTTELTALAGGCRDNARDDEPYRRALRVIRARLSATGAEILDQQPQHQLDLGLPPYATPGELRADLDVIDASLRTHGSALLADDRLALLREAVHVFGFHLCGLDLRQNSDVHEEVVGELLAWAGVHPDYGSLPEDERVALLVGELSTRRPLIGGRAQISDQARGELDIVAAAARAVRTYGAEAVPNYVISMCRSVSDMLEAAILLKEAGLLDASGPQPYCPVGISPLFETIDDLRNGATILQATLDLPLYRGLVKARGDMQEVMLGYSDSNKDGGYLAANWAVYRAELALVETARKSGIRLRLFHGRGGTVGRGGGPSYQAILAQPPGAVSGSLRLTEQGEVIAAKYAEPQMARRNLESLLAATLESTLLDVEGLGDTAAPAYAVLEEVAALSQRAYAELVHETPGFVEYFMASTPVSEIGSLNIGSRPTSRKPTSSIADLRAIPWVLAWSQSRVMLPGWYGAGTAFERWIAAGPEGEADKLDVLHDLYQRWPFFRSVLSNMAQVLAKSDLGLAAHYAELVADESLRRRVFDKIADEHHRTITMYKRITGHDDLLVDNPALARSVFNRFPYLEPLNHLQVELLRRYRSGEDDELVQRGILLTMNGLASALRNSG
>NC_022663.1|WP_036391473.1|5929625_5929859_-|preprotein-translocase-subunit-SecG
MELALQITLVITSVLVVLLVLLHRAKGGGLSTLFGGGVQSSLSGSTVVEKNLDRLTLFITGIWVVCIVGVGLLIKYR
>NC_022663.1|WP_023373263.1|5927165_5929529_-|xanthine-dehydrogenase-family-protein
MRFTHPSGHGPGHDVAAGVPGPLARSEHDLVRGTGKYVDALRFDGEAHGCLVRSPLPHARIRRIDSSRAASAPGVLTVLTGHDIAATIRPLGCVIGLRSDDGTPRVDADRAVLAVDRVRHVGDGVAFVVAETANQAATAAALVDVGYEPLPYRSDADSPELEVPIWADAPDDVCFTWRFGDAPACRALFASAHHVVRITLASPRLVPYPIEPRAAVGIYDEQTDAMTLLANTQGVHFVRNVLARAFDRDPRRLRVLTPAVGGGFGAKIYAYPEHALVLESARRLRRPVRWTATRSESFLSDTQGRGHITDAAIALDKDGRFLALSVRPTVDLGAYLSQLAPLTATGVGAPVQAGAYRFQAVEINVRAMFTNNVPVDAFRGAGRPEANYVLERLIDRAARELGFDPALLRARNLPATQTRPLTAATGLVIDGGRFLDNQIRCLDVADRAGFEARRRESAARGRLRGFGFANYLEANGGLQVAEAMSAGAFPVECATLTFSGDGCLDIVVGTQSSGQDHAVPLQRLAAERLGMDPRHITVREGDSSVAPLGAGTGGSKSLLTSTAALDQALSDAVQRGKQVLADKWGVDAEAVSFADGRFLADAGAGEWFSSSIGEVATHWPGALDGQSEVSLRNGSFANGCHACELEIDPETGCVTVLRYVAVDDFGRVINEGAVRGQVQGAVAHGIAQALLERAPGCEELMRIAAGGAAAYTPPTACEIPDVEWVDNGLPSTTNVLGAKGCGESGTAAAPPAVMNAVADALRDYPAAAGIQMPARPAVIWKAIHEER
>NC_022663.1|WP_023373261.1|5926672_5927179_-|(2Fe-2S)-binding-protein
MKNVEPAGTVRFTVNGAPAEVNVAAHERLVDVLRGPLELTGAAIGCDTAVCGACTVLLDGRTVKSCTVLAVQAADTDVVTVEGLATPDSLHVLQAAFLRHGAVQCGYCTAGMLVAAVDLLTRYGASLDEAIIRDGICGNLCRCTGYRSIVSAIAEAAAEMAADDGSAR
>NC_022663.1|WP_023373259.1|5925893_5926676_-|FAD-binding-domain-containing-protein
MSTRGYHRPTTVGEAVRMLSSVGAVVLAGGQTLVPALTRTPGRSVTLVDLGAVAGLRDIIAGGAEVRIGAMATHTQVATDALVRQAIPSLALLASQIADPQVRNRATIGGSLAYNDPAGDYPAACVGLGATVITDRRRIPAEEFFTGAFSTALAESEVIVSLAFPKPPELLRAAYVRLPDRAARSALVGVTVAETQSAFRVAISGLASGPTRWPDAEAALAKRPHPDALRDIAGPPAGTDPYRAHVARTLTIRAVRSLTT
>NC_022663.1|WP_023373257.1|5924173_5925880_+|FUSC-family-protein
MNHIAALGRSVIAALRPAKAPWVVGPAVWAMATAASIGGVGVLVGDLQVAGVAFLGAACAVGFLATGSYRARWRAMMAQACGGALGIGAGALAPDSAAGLVLMAAIAGTISGLVGGIGASATAFGMMLTVGVAFGQFGGSSLPWWQQVLWYLAGSAVATVALLAAWVFQRGAQERRAVAGVFDAAADLCAAIGAEDAGAARARLAAASAIARSTREHRQADLVALAAAALYARGTPVPDPVIEAIRQAGKQVRAGDPVSVILPERDDPGLLALADALRPAPVRPGAAVPATGRSWASVRAACSRDTVANGVRIGLCLAVATGITVAMHERTHSFWLPLTTAVIVRPEYASVFVRTVNRIFGTLIGALLTTAFLAVWPCGLPVVAATALALGFVVLSAPKLYGLSVVGITSAALLSQSIGQADPNAPAIRLVDTLIGAAVAVVFGYLLWPGARRLPGSARFSSALAAARRYLTEAVKPAGRRRRWQPTRDEAYRLAHQVRAGAEAAVLEPPPVSALAAQAIPAAMELEDVVDAITAISVAVDGGYDAATLIDDVAHRLARLDQSALALR
>NC_022663.1|WP_023373253.1|5921910_5923119_-|PPE-family-protein
MFTDFAFLPPEVISTRMYSGPGSGSLQAAAEGWQQLSAELHASAQTYRSVVSDLIAWHWVGPSSAAMAAAATSYAEWLEATAIQTGQTARQAATAASAFDEAFAMTVPPSIVFANREQLLLLIATNFFGQNTSAIAALELAYAEMWVTNSSVMQDYSVTSAAATKLTPFASPQQATNPAGLPGQAAAVAQATAGAAADGGNWLGNLLEQIGMALLPFAPELTPFFLEAGELINAIPFPSIVADDFTFLDGVMAWYATVSSINNISSLGTGIIGAEKNLGILPSLAAPAAEVVPSELAPLVNSVKNVADAVAKGGPGIGEVTAAFRGAGSIGPMSVPPTWTAPAVTTVKTFQGTPLTTLPAGDAGGAGMPGMPGIAPAGTRRGGVVPRYGLTPRVMTRPLSGG
>NC_022663.1|WP_023373277.1|5936448_5937999_-|glucose-6-phosphate-dehydrogenase
MSAARNSAATQWHNPLRDKLDKRLPRIAGSCGMVIFGVTGDLARKKVMPAIYDLANRGLLPPTFALVGFARRDWDTQDFGQVVYQAVKEHCRTPFRQENWDRLAEGFRFVPGSFDDEQAFARLAETLDKLDAERGTGGNHAFYLAIPPKAFPVVSEQLHKSGLARPQSGRWSRVVIEKPFGHDLDSARELNRAVNAVFPEESVFRIDHYLGKETVQNILALRFANQFWDPIWNAHYVDHVQITMAEDIGLGGRAGYYDGIGAARDVIQNHLMQLLALTAMEEPVSFKPSALQAEKIKVLSATRLAEPLDETSSRGQYTAGWQGGEKVVGLLDEEGFAEDSTTETFAAITLEVDTRRWAGVPFYLRTGKRLGRRVTEIALVFKRAPHLPFDATMTDELGANALVIRVQPDEGMTLRFGSKVPGSAMEVRDVNMDFSYGSAFAEDSPEAYERLILDVLLGEPSLFPVNAEVELAWEILDPVLDYWAAHGKPDPYEAGTWGPDSAFQMLHRTGREWRRP
>NC_022663.1|WP_023373279.1|5937995_5939114_-|transaldolase
MSQNPNLAALSAVGVSVWLDDLSRDRLNSGNLQELIDTKCVVGVTTNPSIFQKALAEGDAYNGQIAELAERGADVDATVRTATTDDVRRACDVFAPVWEASDGLDGRVSIEVDPRLAHDTDKTIQQAVELWKIVDRPNLFIKIPATKAGLPAITAVLAEGISVNVTLIFSVERYREVVDAYLAGIEKAREAGQDLSKIHSVASFFVSRVDTEIDKRLEKLGSQDAVALRGQAGVANARLAYAAYQEVFGGGDRFRALKTHGARVQRPLWASTGVKNPDYADTLYVTELAAPDTVNTMPEPTLDAVADHGVIKGDTVSGTASDAQQVFDKLQAAGVDLDDVFVVLEDEGVAKFEAAWTELLKETQAQLDSVTK
>NC_022663.1|WP_023373281.1|5939128_5941219_-|transketolase
MTTLEEISTLTQPRHPDDWTEIDSAAVDTIRVLAADAVQKVGNGHPGTAMSLAPLAYTLFQRTMVHDPSDTTWLGRDRFVLSCGHSSLTLYIQLYLGGFGLELSDIESLRTWGSKTPGHPEFRHTRGVEITTGPLGQGLASAVGMAMASRYERGLFDPDAEPGTSPFDHHIYVIASDGDIEEGVTSEASSLAAVQQLGNLIVFYDHNQISIEDDTNIALCEDTAARYRAYGWHVQEVEGGENVVGIEEAIANAKAVTDRPSFISLRTIIGYPAPNLMNTGKAHGAALGDDEVAAVKKVLGFDPDKTFEVREDVLTHTRGLVARGKEAHDRWQVEFDAWAQREPERKALLDRLTAEQLPDGWDDDLPHWEPGSKALATRAASGEVLSALGPKLPELWGGSADLAGSNNTTMKGADSFGPPSISTKDYTAHWYGRTLHFGVREHAMGAILSGIVLHGPTRAYGGTFLQFSDYMRPAVRLAALMDIDTIYVWTHDSIGLGEDGPTHQPIEHLAALRAIPQLSVVRPGDANETAYAWRTILARGNGSGPVGLILTRQGLPILEGTSAEGVARGGYVLGDDSDDEPDVVIIATGSELQLAVEAQKLLADKDIIARVVSMPCVEWFESQPPDYRDSVLPPSVSARVAVEAGVAQCWHKLVGDTGEIISIEHYGESADYKTLFREFGFTAQAVAAAAERALDN
>NC_022663.1|WP_099318754.1|5941512_5942496_+|protoheme-IX-farnesyltransferase
MSDRGRVATGRIPGIPGMARRHYAPGTATSKKSRALATALAYLALTKPRVIELLLVTAIPAMLLADRGSVHPLVILNTLIGGMMAAGGANTLNCVADADIDKVMKRTARRPLARAAVPTRSALAFGLALTVVSVLWLWWTTNLLSGLLALATVAFYVFVYTLLLKRRTSQNVVWGGAAGCMPVMIGWSAVTGTLAWPALAMFAIVFFWTPPHTWALAMRYKEDYQEAGVPMLPAVATERQVTRQILIYTWLTVLATLALTPATGWLYAAVAVVAGAWFLAMAHQLDAGVRAGEPVKPLRLFLQSNNYLALVFCALAVDSALGLPTLL
>NC_022663.1|WP_023373285.1|5942674_5946388_+|trehalose-phosphatase
MKSFTIDPRRHDGVIFVLDTPAVSTRPEPDNSVMESTLALAHRLRQAGLVTALYSPAGHSIRVLEATGIAEPFTARVERAPAGAPELPTKRYCIGLLAAAGKLGVAAERSAVVAGDSGGVAAARECGFAYVVGLDQEGHPDELLHCGADVVVADLSDVMVRTGDECMSRRPNALDSYGQVIGMVSGRQPFVCVNYDSTLSEIVPDPDLATLVDGAAEALADLSMQCPVAMLSGRDLADIRNRVGLPGIWYAGSHGFDLMAPDGTRYQHDAAAAAVPVMASAATTLQEELGPTSGAHVEHTRFGVRVHYGKVAHEQVPDVIAAAHRQSRRHGLRLITGRGVVELRPDVDWDKGTALAWIRDHVIESGVESGPQPGRVLPIYIGGDLTDEDAFDAVRFSGIGVVVRHDRDGDRPTAASFTLTSPTEARDFVRRGARWLAYDRETRARGWTFTWEGYDPPNEKLREALCTVGNGYFATRGAAPESKAGQVHYPGTYAAGVYNRLDDLVAGTRTAHESLVNLPNWLPLTFRIGDGDWLDLDAVTLLSYRQTLDLRGAVLTRELTYRDDAGRTTSITQHRFVAMNQVHVAALQTTVVAQDWEGTIEIRSTLDGDVRNSGVERYRDLASNHLQGLEKVALSENSVLMSVETTQSKIPVALAARTSVWHGDAPAPATYRLLDEEFEIGHQIFADLKPGQPLTVEKIVTLVTGRDVATSHPSTGAERRLARQGRFAETCAAHRLAWAHLWERVSIEFSNHTEELRVLRLHLLHLLQTVSYNSEELDVGVPARGLHGEAYRGHIFWDELFIFPVLNLRVPTVTRSLLRYRHRRLVEARGAAKLAGYRGAMYPWQSGSDGREESPEQHLNPRSGRWRPDASHRAHHIGIAVAYNVWNFYQVTGDLAYMIDYGTEMMAEIARFWVSRATYDRDRDRYTINGVIGPDEFHSGYPDRPYDGVDNNAYTNVMAVWVILRAIDALQLMPLPNRLDLCEELGLTDEELAHWDHVSRRMFVPFHDGVISQFEGYEQLLELDWDAYRRRYRNIQRLDRILEAEDDDVNRYRASKQADVLMLLYLLSADELRELLDRLDYHLDPRRIPEMVDYYLARTSHGSTLSAVVHGWVLARANRDRALEFFQQVLKSDIADIQGGTTSEGVHLAAMAGSVDFVQRCFTGLEIRGDRIVLSPLWPEYLGALGFPIHYRGNHLHLRVSGKGAEISVEPRDVPPVEIECRGRVELLVPGSVVRFT
>NC_022663.1|WP_133163590.1|5946467_5947049_-|hypothetical-protein
MKHELNAAGIPEDTIFQLVNSRYDYPQAVPIMVDWLQNLDERIPAEEDRRAWRVALIRNLITKNAKGNRVAADILFHQFDIDPPLSGLELEVTGFALAEVCDGSDFPRVAALLRSGKDFSTKFELVRWLGRFKTEEAKELVVSQLADPTTRADAMAALVRQRATGVRVTVARYLNDEVWRKEAQKTLDKLPPD
>NC_022663.1|WP_169733145.1|5947099_5948428_-|hypothetical-protein
MGGAAMTDVDPELFYDAAAAYKENSDHAGAALRKLAGVDAAGAAGTHGVGPQWASSYDAAAEEAGQVAYRLVNVFHNLGSLLRQNGINHDQTEEASTLNQRDAYGAPITPPGESAGTFIDAAVAVSSVAGGGDPEPPHWNLVADRIVDGWPDGHPDHALAASAAWETFGHDLVRIDDQPGPEEQRLIVDVEAAEIAPLVDRLEEARGVNTDIAGACGDLSRAAKDYGNKLKSVKDDMAFVVNQLHWLIIILDSYPPVPHRLTGPIKETFIAAAVTQINGLNAALRTIATASMTDLTAAGSAMGAALPAVKRLLDLVPRRVNPTPTHRVNDNRRKGRRAEDIAGIDQSKKVRIPVRNPKPGRPRFRIPDEIDDENHVVREVKNVKKLDTTQQIRDIAEWARDNGYKLVIVVDKGRTDAGSVEQTLERDFEGLDVVIDDSKNLS
>NC_022663.1|WP_023373292.1|5948512_5949640_+|hypothetical-protein
MSYDLTVYAASSIDDEQLEEIVASVPGLSVGDSGDHEMTVLRGKQEKYSFTVFGPHEIEPEDVPDDVVPHVLDPTTSWQIVIEGSDPAEVRPARRFAKALARAAGGVAVDEQTEEILGAKRARQIASPGSELIRIVDLQWHSPESAPDAATLWLELARKFLPEALPRRFGNVYPLRYRLDRDGDDQFIATFASHGAWFKATLPCIDGGLYLEPWDGILIDTLKMVAQPLDDPPWRNTVQRFFVEYARRRGSVLATGEVLRNHKLSGPPDTSWDLSGSLRGPGGILGLPANPVWWTWLGNDYLPLVRDYLPPEHTTYYDEGALYAPTEEPTDRGQLAGLPDPFPASLRVTAIPSEYGPSNTPMNSPAAIRPRLNQG
>NC_022663.1|WP_023373294.1|5949636_5949927_-|hypothetical-protein
MARRTVNEHDLVDAADAMRQFCLVMKDRLNEVATELRGLQHHWEGVAFDAFLERVQHWQGWADEMSEVVFDMHLNAHIAHRNYVHNAEVNTAMWGG
>NC_022663.1|WP_129111742.1|5949929_5950256_-|WXG100-family-type-VII-secretion-target
MAAEELRVYCAELAHASKTTTGAADEIDGLRDKLGGQTDGLAGTWTGQAASAYLDVWAEIDDECGQMLADLRWIGESLAAAAAGYAQMEHAAADAFGSIRPAGPVDGR

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Crispr_ID: NC_022663_20

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022663_20

6379425-6380393

Orphan

Consensus_repeat	Method
CAACATCGCCACCGTGGCCACCGC	CRISPRCasFinder

13 spacers

The CRISPR arrays of NC_022663_20

>merge|NC_022663|20|6379425-6380393|CRISPRCasFinder
CAATATCGCCAACGTGTCCACCGCGTTGTTCAGCAACAACAACACGCTCTCGGCCAGCTCGTTCGGCGTGGAGAACATCGCCACGGTGGCCACCTCGATCGGTGACAACAACGGGGTCTCGGCCACCAATTCACTGGGTGTCGGCGGCAATATCGCCACCGTCGCCACCGCGATCGGTTTCGGCCAGGGCGACAATCAGGTTGCCGCCGAATCCGGTGCCGGGGGCGGCAATATCGCCTCGGTGGCCACGGTGTTGTTCGGTGGCAACAACACAGTTTCGGCCAGCGGGCTGGGTGCAGGAAATATCGCCGACGTGGCGACCGTGCTGTTCAGCAGCCACAGCACCGCCCACGCCAGCGCGTTGGGCGTGGAGAATATCGCCACCGTGGCCACCTCCTTGGGTGACGGCAACAACGTCTCGGCCAGCGCGCCCGGCATCGGGGGCAACATCGCCACCGTGGCCACCGCTCTCGGCCAGGGCAACACCGCGGTTGAGGCCGTGGCCGGCCCCGGCGGCGCCAACATCGCCACCGTGGCGACCGCCTTGGGTGACGGCAACAGCGTCACGAACAAGGCGCTGGGCGCGACCAATATCGCCAGCGTCGCCACCGTCATCGGGGACAACAACACCGCAGACGTCAATGTGATCGGCGTGGAAAACATCGCCACCGTGGCTACGGCAATCGGTGACAACAACGGAATTTCCGCCGGCGCACCGGGACTGGGCGCCAATATCGCCACCGTCGCCACCGCCATCGGCAGCGACAACAGTCAGGTCAGCGCCGTGTCCGGCGCCGGAGGCGGCAATATCGCCTCGGTGGCCACCGTGATCGGAGACAAGAACTCGGCTTCCGCCAGCGCGCTGGGCGCCGGCAACATCGCCACGGTGTCGACCGTGTTGTTCAGCAGCAACAACACGTCCTCGGCCAGCGCTCTCGGCATCGAGAACATCGCCACGGTGGCGACCTC

>NC_022663|20|16|6379425-6380393|CRISPRCasFinder
CAATATCGCCAACGTGTCCACCGC	GTTGTTCAGCAACAACAACACGCTCTCGGCCAGCTCGTTCGGCGTGGA
GAACATCGCCACGGTGGCCACCTC	GATCGGTGACAACAACGGGGTCTCGGCCACCAATTCACTGGGTGTCGGCGG
CAATATCGCCACCGTCGCCACCGC	GATCGGTTTCGGCCAGGGCGACAATCAGGTTGCCGCCGAATCCGGTGCCGGGGGCGG
CAATATCGCCTCGGTGGCCACGGT	GTTGTTCGGTGGCAACAACACAGTTTCGGCCAGCGGGCTGGGTGCAGG
AAATATCGCCGACGTGGCGACCGT	GCTGTTCAGCAGCCACAGCACCGCCCACGCCAGCGCGTTGGGCGTGGA
GAATATCGCCACCGTGGCCACCTC	CTTGGGTGACGGCAACAACGTCTCGGCCAGCGCGCCCGGCATCGGGGG
CAACATCGCCACCGTGGCCACCGC	TCTCGGCCAGGGCAACACCGCGGTTGAGGCCGTGGCCGGCCCCGGCGGCGC
CAACATCGCCACCGTGGCGACCGC	CTTGGGTGACGGCAACAGCGTCACGAACAAGGCGCTGGGCGCGAC
CAATATCGCCAGCGTCGCCACCGT	CATCGGGGACAACAACACCGCAGACGTCAATGTGATCGGCGTGGA
AAACATCGCCACCGTGGCTACGGC	AATCGGTGACAACAACGGAATTTCCGCCGGCGCACCGGGACTGGGCGC
CAATATCGCCACCGTCGCCACCGC	CATCGGCAGCGACAACAGTCAGGTCAGCGCCGTGTCCGGCGCCGGAGGCGG
CAATATCGCCTCGGTGGCCACCGT	GATCGGAGACAAGAACTCGGCTTCCGCCAGCGCGCTGGGCGCCGG
CAACATCGCCACGGTGTCGACCGT	GTTGTTCAGCAGCAACAACACGTCCTCGGCCAGCGCTCTCGGCATCGA
GAACATCGCCACGGTGGCGACCTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_022663.1\|WP_023373999.1\|6366009_6367833_+\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_022663.1\|WP_023374026.1\|6387135_6390042_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|226415
NC_022663.1\|WP_036394260.1\|6395356_6395662_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227505
NC_022663.1\|WP_023374005.1\|6370235_6371732_-\|potassium/proton-antiporter	unknown	unknown	gnl\|CDD\|235410
NC_022663.1\|WP_023374019.1\|6383321_6384158_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235975
NC_022663.1\|WP_023374034.1\|6393554_6394898_-\|PPE-family-protein	unknown	unknown	gnl\|CDD\|366325
NC_022663.1\|WP_023374011.1\|6374940_6375462_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|214643
NC_022663.1\|WP_023374001.1\|6367968_6368832_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|367049
NC_022663.1\|WP_042314102.1\|6365136_6365877_+\|hypothetical-protein	unknown	unknown	unknown
NC_022663.1\|WP_036394268.1\|6384308_6385586_+\|divalent-metal-cation-transporter	unknown	unknown	gnl\|CDD\|334596
NC_022663.1\|WP_023374003.1\|6368928_6370269_+\|acyltransferase	unknown	unknown	gnl\|CDD\|376607
NC_022663.1\|WP_036394270.1\|6382765_6383248_-\|flavin-reductase-family-protein	unknown	unknown	gnl\|CDD\|224766
NC_022663.1\|WP_023374024.1\|6385603_6386980_-\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223354
NC_022663.1\|WP_023374013.1\|6375765_6377259_+\|DUF4185-domain-containing-protein	unknown	unknown	gnl\|CDD\|379383
NC_022663.1\|WP_023374028.1\|6390045_6390315_-\|DUF4242-domain-containing-protein	unknown	unknown	gnl\|CDD\|379428
NC_022663.1\|WP_023374009.1\|6372673_6375007_+\|RNA-binding-transcriptional-accessory-protein	unknown	unknown	gnl\|CDD\|225094
NC_022663.1\|WP_023373995.1\|6363517_6365068_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|365860
NC_022663.1\|WP_042314104.1\|6390689_6391715_+\|alpha/beta-hydrolase-fold-domain-containing-protein	unknown	unknown	gnl\|CDD\|369561
NC_022663.1\|WP_036394264.1\|6392043_6393486_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_022663.1\|WP_023374007.1\|6371885_6372590_+\|TrkA-family-potassium-uptake-protein	unknown	unknown	gnl\|CDD\|223643

Protein	Function_ID	Function_description	E-value
NC_022663.1\|WP_023373999.1\|6366009_6367833_+\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	4.26757e-118
NC_022663.1\|WP_023374026.1\|6387135_6390042_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|226415	COG3899, COG3899, Predicted ATPase [General function prediction only].	4.30032e-29
NC_022663.1\|WP_036394260.1\|6395356_6395662_-\|hypothetical-protein	gnl\|CDD\|227505	COG5178, PRP8, U5 snRNP spliceosome subunit [RNA processing and modification].	0.00573726
NC_022663.1\|WP_023374005.1\|6370235_6371732_-\|potassium/proton-antiporter	gnl\|CDD\|235410	PRK05326, PRK05326, potassium/proton antiporter.	0
NC_022663.1\|WP_023374019.1\|6383321_6384158_-\|SDR-family-oxidoreductase	gnl\|CDD\|235975	PRK07231, FabG-like, SDR family oxidoreductase.	4.37223e-74
NC_022663.1\|WP_023374034.1\|6393554_6394898_-\|PPE-family-protein	gnl\|CDD\|366325	pfam00823, PPE, PPE family. This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	1.6793e-54
NC_022663.1\|WP_023374011.1\|6374940_6375462_-\|ATP-binding-protein	gnl\|CDD\|214643	smart00387, HATPase_c, Histidine kinase-like ATPases. Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.	4.24835e-07
NC_022663.1\|WP_023374001.1\|6367968_6368832_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|367049	pfam02353, CMAS, Mycolic acid cyclopropane synthetase. This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.	1.33541e-166
NC_022663.1\|WP_036394268.1\|6384308_6385586_+\|divalent-metal-cation-transporter	gnl\|CDD\|334596	pfam01566, Nramp, Natural resistance-associated macrophage protein. The natural resistance-associated macrophage protein (NRAMP) family consists of Nramp1, Nramp2, and yeast proteins Smf1 and Smf2. The NRAMP family is a novel family of functional related proteins defined by a conserved hydrophobic core of ten transmembrane domains. This family of membrane proteins are divalent cation transporters. Nramp1 is an integral membrane protein expressed exclusively in cells of the immune system and is recruited to the membrane of a phagosome upon phagocytosis. By controlling divalent cation concentrations Nramp1 may regulate the interphagosomal replication of bacteria. Mutations in Nramp1 may genetically predispose an individual to susceptibility to diseases including leprosy and tuberculosis conversely this might however provide protection form rheumatoid arthritis. Nramp2 is a multiple divalent cation transporter for Fe2+, Mn2+ and Zn2+ amongst others it is expressed at high levels in the intestine; and is major transferrin-independent iron uptake system in mammals. The yeast proteins Smf1 and Smf2 may also transport divalent cations.	1.71202e-62
NC_022663.1\|WP_023374003.1\|6368928_6370269_+\|acyltransferase	gnl\|CDD\|376607	pfam01757, Acyl_transf_3, Acyltransferase family. This family includes a range of acyltransferase enzymes. This domain is found in many as yet uncharacterized C. elegans proteins and it is approximately 300 amino acids long.	1.21924e-08
NC_022663.1\|WP_036394270.1\|6382765_6383248_-\|flavin-reductase-family-protein	gnl\|CDD\|224766	COG1853, COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only].	2.9614e-26
NC_022663.1\|WP_023374024.1\|6385603_6386980_-\|FAD-binding-oxidoreductase	gnl\|CDD\|223354	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion].	1.50209e-44
NC_022663.1\|WP_023374013.1\|6375765_6377259_+\|DUF4185-domain-containing-protein	gnl\|CDD\|379383	pfam13810, DUF4185, Domain of unknown function (DUF4185).	2.72381e-154
NC_022663.1\|WP_023374028.1\|6390045_6390315_-\|DUF4242-domain-containing-protein	gnl\|CDD\|379428	pfam14026, DUF4242, Protein of unknown function (DUF4242). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 90 and 170 amino acids in length. There is a single completely conserved residue C that may be functionally important.	5.87399e-21
NC_022663.1\|WP_023374009.1\|6372673_6375007_+\|RNA-binding-transcriptional-accessory-protein	gnl\|CDD\|225094	COG2183, Tex, Transcriptional accessory protein [Transcription].	0
NC_022663.1\|WP_023373995.1\|6363517_6365068_+\|MFS-transporter	gnl\|CDD\|365860	pfam00083, Sugar_tr, Sugar (and other) transporter.	3.19722e-43
NC_022663.1\|WP_042314104.1\|6390689_6391715_+\|alpha/beta-hydrolase-fold-domain-containing-protein	gnl\|CDD\|369561	pfam07859, Abhydrolase_3, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	2.88361e-44
NC_022663.1\|WP_036394264.1\|6392043_6393486_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	5.17431e-107
NC_022663.1\|WP_023374007.1\|6371885_6372590_+\|TrkA-family-potassium-uptake-protein	gnl\|CDD\|223643	COG0569, TrkA, K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism].	1.22005e-43

>NC_022663.1|WP_023374013.1|6375765_6377259_+|DUF4185-domain-containing-protein
MSAIHRVVSVSVASAAALGLISAVGLAPAATAVPCSGDAANAPPPPNAIVTNPGGTTLGPMTRGPRPRGANDRAPLPRLGPLSRLLNPAPRSAPLQQQAATPPHQAAVPPPAPPNPGNQPPNAAQLAPNAAPPPAPAPAAVPAPGAPDPGAALGGATTSLAEWVTGPDSPNKTLQQFGISGTDLGIIWDNGDPANHQVLMAFGDTFGYCAVNEHQWRYNTLFRSQDRDLGDGIHVAPGDAANRYSGSPVRQPGFSKQIISSIKWAPNETGIIPTSGVSVGKTQYVSFMSIRDWGRDGEWTTNYSGIAVSKDNGQNWGVYPGTIRASGPDSGRARFVPGNENFQMGAFVKSNDGYLYSFGTPPGRGGSAYLARVPQQFVPDLSKYQYWNGDSNSWVPGKPDAATPVIPGPVGEMSAQYNTYLKQYLVMYTNGMNDVVARTAPAPQGPWSPEQMLVSSWQMPGGIYAPMMHPWSTGKDVYFNLSLWSAYNVMLMHTTLG
>NC_022663.1|WP_023374011.1|6374940_6375462_-|ATP-binding-protein
MLSHAFKFTFAGHVDVALRTLPKHVELTVHDTGIGEGRTAVSVPAVPPRPGSPATAPARAPASNWVRRRTGARPSEKLEATGRIRVASEVDTDTTFTVWIPLGRRRRDETVEGQPPRISEIAAALAEEAEQWDAQRDERAARGHTGPRRRPAHLPKPASRNARAIEPAGELAG
>NC_022663.1|WP_023374009.1|6372673_6375007_+|RNA-binding-transcriptional-accessory-protein
MNPSTAIKSVTARLAEELAVEEAHVAAAVGLLDGGATVPFIARYRKEATGGLDDGQLRTLAERLQYLRELDERRAAVLASIREQGKLTDELRAALLSADTKSRVEDIYLPYKPKRRTKAQIAREAGLEPLADRLLSDPGLVPEAAAAAFVCADVGDAADVAAALEGARHIMVERAAEDAELVGAIREKFWAQGTLGSAPWSQDVAKSAAAQNFRDYFGFSESLQTMPSHRVLAVLRGEKEKILALTFDGGADDGYEAMVAASLGVDLSADVSAKAATPWLAATVRFAWRTRLMSSAAVDARIRLRQRAEQQAVAVFAKNLTHLLLAAPAGARTTLGLDPGFRTGVKVAVVDPTGKVVDTCAIYPHQPQRQWDLAKATLAALVARHSVELIAVGNGTASRETDTLAAELINDIRAAGGPALTKAMVSEAGASVYSASAYAARELPELDVTLRGAVSIARRLQDPLAELVKIDPKSIGVGQYQHDVTPAVLARSLDAVVEDAVNAVGVDLNTASIPLLSRVSGISESLAEAIVAYRDKTGAFASRRALLEVPRLGPKAFEQCAGFLRIRDGDDPLDASGVHPEAYPVVHRILDRTGLSLAEIIGDAGALRSLRPADFADDRFGIPTVIDILAELEKPGRDPRPTFTTATFAAGVQKIADLKVGMVLEGVVTNVAAFGAFVDIGVHQDGLVHVSAMAERFVADPHDVVRSGQVVRVKVIDVDVERRRIGLSLRLNDDPQRQPVSRPERRNSVHGKNFGRQPANSPAGSMARALRDAGFGR
>NC_022663.1|WP_023374007.1|6371885_6372590_+|TrkA-family-potassium-uptake-protein
MRIAVAGAGKVGRSVAHELLDRGHKVLLIERQRNNFEPHTVPAADWLHADACELSTMHEAGVQTCDVLIAATGDDKANLVVGLLAKTEFGVPRVVARINDLHNEWLFGRSWGIDVAVSTPGAMIAGVEGAIDVGHLVRMMVLREGRAALTKLTLPEDNPLVGRRVCELDLPANTALVTVLRGDAVKVPQPGDVLRAGDEMLFIADSFLERSVWAAMYSTAPARASTRPGRPPSA
>NC_022663.1|WP_023374005.1|6370235_6371732_-|potassium/proton-antiporter
MSLQQLYLALLIGGLVLLASIVGTRLATRVGFPSMLLFLLVGVAVGEDGLGLKFDDVQLARNVGTAALALILVEGGLTTRFTDIRTVLGPAATLATVGVLGSTAVTAVGAHLLLRVDWQVALLLGAIVSSTDAAAVFSVLRVLPLPRRVAGLLEAESGFNDAPAVILVLMFSAVPFAVEPGRAIADLLFELLAGAAVGVAIGYLGAFALRRIALPASGLYPIATFGLGLVAFAAAGASHASGFIAAYLAAVVLANTGLPHRSATRSFAEGVGWLAQIGLFVLLGLLVNPGEVAHDVVAAIVVGLLLLLIARPLSVVASLAAFRIPWHDQVFLSLAGLRGAVPIVLATFPVVAGVPDSYRLLNIVFMLVVVFTLVQGPSLRPIAHRLGLFSREATREIQVEAAPLDVLDAELLTMTVQPPSRLHNVTVLELRLPDPAVITLIIRNGHTFVPMPDTRIERGDELLIVTTSKTRAAAESRLRAVSRRGKLAYWFDEYGEPD
>NC_022663.1|WP_023374003.1|6368928_6370269_+|acyltransferase
MPATQFDAAATAHHTPADRDRAVDVARLGALVVVMFGHCALLLATIDSHGVRIANLLGELPALTPITWLVQVMPLFFLAGGAAGAYGWHAGAPWGTWLFTRAQRLCRPVFWYLACWVTALLAVRVTLGAESAVALGRECVALLWFLGVYLVVLAFVPVLTRLRTGRGVAAVVASLLAAATAVDQIRFAAGTPESGVANFLIVWLIPVVIGVGYARRLIGPRIALVAAGCAFTAQLKLALTSAYDVSLVVTGAERMSNVSPPTLLLALHCTWMSCAFVAAAGAIRRWAARPRVWHVVAVGNGGAMTLYLWHIPSIAVAAVALHAAGLDAYEVHAPGFWARLALRAIVFTIVMAGVFRLLAPLEHRRLPWWDGPVQATGVRSVAAGVLVVAAGVALVALAKNGLGGVEGWTALGCFLAALLAARTSSGPVSWPTPAGRQSGSPYSSNQ
>NC_022663.1|WP_023374001.1|6367968_6368832_+|class-I-SAM-dependent-methyltransferase
MAGQLTPHFDDVQAHYDLSDDFFRLFLDPTQTYSCAYFERDDMTLEQAQLAKIDLSLGKLGLQPGMTLLDVGCGWGATMRRAIEKYGVNVVGLTLSKNQAAHVQKTFDELDSPRSRTVLLAGWEQFDEPVDRIVSIGAFEHFGHDRHADFFARAYQMLPADGAMLLHTITGLTMQQMVDAGLPLTLWLARFLKFIQTEIFPGGHPPTIEMVGEQSAKAGFTLTRRQSLRLHYARTLDLWAEALQAHQDEAIAIQSEEVYERYMKYLTGCAKLFRDGYIDVNQFTLQK
>NC_022663.1|WP_023373999.1|6366009_6367833_+|protein-kinase
MGDTTADSREGSQFGQYRLRRLVGRGAMGDVYEAEDTVRERVVALKLMSPTLSSDPVFRTRMQREARTAGRLHEPHVVPIHDYGEIDGQLYVDMRLIDGKDLAAILKRYGPLTPPRAVAVVRQIGSALDAAHAAGVTHRDVKPENILVSGDDFAYLVDFGIASATSDEKLTQLGSTVGTLYYMAPERFANTEVTYRADIYALACVLYECLTGSPPYRGDQLSVMGAHLSQAIPRPSAARPGIPAAFDQVIARGMAKDPADRYATCGDLSAAAYAALATPDQDRATDILQRSQVAQLPAAAVGQPAAGFAPPMPTPSTPAAQPAGWSPPTPPGSPVPTGAPQPTPWTGATGWGTGYPGTAGAPPWGQPPVQPSGGGGAPWLWVGVAVAVVVAVAAGLGIVVAKPWRSSAPRPGPTSPPAADAVELRVLNDGVFVGSSAAATTIDIFNEPICPPCGAFIRSYASDIETAVADKKLAVRYHLLNFLDDQSHTKNYSTRAVAASYCVADQNDPKVYSDFYAALFGSDFQPQEGAASDRTDAELAHLAQTVGANTTAISCIKSGSDRGTAQSKAAAASETLATFSANGTPFVWDGKKAVDLQNSSWLTRLTG
>NC_022663.1|WP_042314102.1|6365136_6365877_+|hypothetical-protein
MTSTLLDEALEAHGGLQRWQSAAEIHSRVRSGGLLVRTRVPGNRFEDYRITVDVQEPRTVIDPFPVDGQRGVFDNGTVRIESHDGHVISSRANPRPAFFGRSGLRRNFRWDPLDSVYFAGYAMWNYLTTPYLLTRDGVEVDEAGTWREGGETWRRLNATFPAHIHTHSPRQSFYFDAGGRLRRHDYVAEVVGHWARAAHYCTEPVDAGGLVFQTRRRVYPIGPGNRPLPAPTLVSMQLSDLRVDTG
>NC_022663.1|WP_023373995.1|6363517_6365068_+|MFS-transporter
MSASAQTGTITTQVPARLDRLPWGRFHWRVVIGLGGVWILDGLEVTMVGNVSSRLTEHGSGIELNAADIGLAASFYIAGACLGALFFGHLTDRFGRRNLFLLTLAVYLIATVATAFAFAPWYFFLTRFFTGSGIGGEYAAINSAIDELIPARVRGRVDLVINGTYWLGSAAGAAGALVVLDTSNFPPNIGWRLAFGVGAIFGIFVLLVRRNVPESPRWLFIHGREHEAERIVGEIEGEVERDTGQPLPEPQGRPLKVRQRHTISFWEIARVAFTLYPRRAVLGLALFIGQAFLYNGVTFNLGTLLSGFYGVASAHVPVFFIVWALSNFVGPLVLGRLFDTIGRKPMITFSYIGSAVVAVVLAALFVTGTGGVWTFIIVLAVAFFLASAGASAAYLTVSEIFPMETRALAIAFFYATGTAIGGISGPLLFGQLINSGQRSQVFWSFLIGAVVMAAAGLVELWLGVAAERRPLEELALPLTVADAEQDEEPTDARDRQRAGTAPVHDDDPHGGHAERP
>NC_022663.1|WP_036394270.1|6382765_6383248_-|flavin-reductase-family-protein
MEAFDKLVSLLDYPIFVVTAAAGGAPAGCLVGFASQASIHPPRFLVGLSQQNHTFRVAAGADHLAVHLFDREHLDVVELFGSRSGDTVNKFDRCSWHLGPARTPILDDAAAWFVGRILDRFPLGDHVGYLLEPVDGSPPHQLEQWVSFRDVRGLPPGHEA
>NC_022663.1|WP_023374019.1|6383321_6384158_-|SDR-family-oxidoreductase
MNDPMHGRPLLADRVAVVTGGGGGIGAATSRLFAEHGARVVVADIDPDLAQQTVAEIGDPAFAVVTDVRDAGQVRALARTVLDRCGRADVLVNNVGHWLRHPGDFVDTHPELWDELYRVNLHHVLLATHAFLPAMIDRHAGAIVNVSSVEGLRGYPEDPVYAAFKAAVIHFTRSLAVQVGHHGVRVNAIAPDVTESLQVPYSQWLSDDEKAQWPQWVPVGRMGVPLDQARAILFLACDLSAFVTGHTIPTDGGTGAAGGWFRSSRRPDREWTNRPIAP
>NC_022663.1|WP_036394268.1|6384308_6385586_+|divalent-metal-cation-transporter
MTGASRTSEERSSPRSVRSRGRWALLAVWGPGLVVMLADTDAGSLITAAQSGAQWGYRMVLPQLILMPILYVVQEMTVRLGIVTGRGHGALIRERFGRGWAWLSAFTLFASAIGALLTEFVGVAGVGELFGVSRWVSIPIATTMLLALALTGSYRRVERIGLAIGAAELAFLVAMVMARPQFDALLAGLSSMPLGNSSYLLLVAANVGAVIMPWMIFYQQGAVVDKHLSVATIRQARYDTATGAVLTQLIMIAVVLTVAATIGTHQEAAPLQTVGQIAGALTPYLGKLGGTVLFGLGMLGAALVAAIVASLAGAWGLSEVFGWQHTLNQRPTRATAKFYTTYALAHLVGAALVLGSVDLVNLAVDVEVMNALLLPIVLGLLLVLEARALPEQWRMSGVRKYTTRALCLVVIAFGLYMVPQALGWT
>NC_022663.1|WP_023374024.1|6385603_6386980_-|FAD-binding-oxidoreductase
MSLTTETDELRTRLGAQLILPDDPGYDEARAVHNAMIDKRPAMIARCASAADVAAALEFARTSNLAVAIRGGGHNGPGFGTVDGGLVIDLSPMNRIDVDADRRTVRVQGGATWGQVDAATSAHGLATPSGIISTTGVGGLTLGGGHGYLSRKYGLTIDNLLEAELVLADGRMVTASESQHPDLFWALRGGGGNFGVATAFTFRLHPVPTVICGPTAWPASATADILSWYRDYLPAQDEDLYGFFAAMTVPPVAPFPEAFHLHKACAVVWCYTGDPAAAEEVFAPVRQMEPAFDGLGAAPYPALQTTFDALYPKGLQWYWRGDFFRTIPDGAVQAHARFTEELPTMHSTMHLYPIDGAVHRAGPTDTAWAYRDVNFSQVIAGVDPDPANAAALKRWTVDYWDATHPYSAGGAYVNFMMDEGQDRVRATYGPNYRRLSEVKATYDPHNVFHINQNIVPAR
>NC_022663.1|WP_023374026.1|6387135_6390042_+|helix-turn-helix-transcriptional-regulator
MAQWVQPPLPAELIARRGGPMVGRDAELAVFEQAWERVESGNRQAVFVGGEPGAGKTRLVAEVAGTLAEHGVAVLVGGSTADAGVPYAPFTEALDRLLTTGPPGSMGELLADVAVQLRRLTTEVDRHLPGVAAEDDVGAPRRALFDALTGFLRRLSVDRPIALVLEDLHWAQLPTLAMLEHVLIGCADVRMLVVATFRTTEPDRTEELVTRLADLHRFDGVRRLDLEGLDTEAIAEFVRRTQQLPTPSLRSTAALLRDKTGGNPFFLNELCNHLEIRGGIAALGSQRTVPASIGDAIARRLGGLGATVREVVEQAAVLGQTFDLPALIATSQTDLTATLAAVDSAEAVGLVRAVPDSDGEFAFVHALTREAVLGGMAASRLRILHARAAEALQGRADPSVIPRLANHYLVAHVLGYHEQALRYAGQAARMAEQSLAYEDAAKWYERAASLAELKLADRAKLNLWAAANHMRAGDFARARAIYERISAIEDPLIRLEAAVGYEDASWRPGLADSKAADLLASALESCGLDTDDPRYIHALGSFGRALGFAGEAARAREISDRAIELARAVDDPTVVQHALMTSLWHLTPDMCAIQEERSTELLHAAQARRDYDALGSAAHFRAMVSYLTGRPEALAASAADMQRSVQACGQPFFGFISACVEQALAFLRGDFAGAERWADIALRTGNSFGADGTEGSHGVQMFMIRRETGGLDRFAGFVDGSERFAGRWVPGLLALYTELNCERGMARALNHLLNRNLGDHTDEAQWTMELVFMTEAALALGNREAVHALRPFIARYAGKNLLAGQFVALFGSADRYLARIAALGGDDQAAERLFGAALEMDRRMGSVVHVSETLARQALFEASRGRAEAARRLADEACAIAGPIGQVRVLGLVDSLLTGDLAGPDGLTDREIEVLRLLAAGLSNRAIGERLYISTNTAANHVRSILIKTGAANRTQAAMYAADHQLLG
>NC_022663.1|WP_023374028.1|6390045_6390315_-|DUF4242-domain-containing-protein
MPIFMVERTYAEKLEPTFEVADGINRINAEEGVRWLYSFLSADKRKTYCLYEAPSPEAIRTAASRAGLPADVIVEVSERVLPDGASTDI
>NC_022663.1|WP_042314104.1|6390689_6391715_+|alpha/beta-hydrolase-fold-domain-containing-protein
MIKNPRHTRARKPDGRRIHHRHSPQSIAVSLASRLIVKNTVRAWAIQPNLRWPFDYIDSLAGLLPRFRSSVRIDPVRLDHCAAEWVRATGVSPTRAILYLHGGAFLTCGLNTHRSLVCRLSRAADAGVLTVGYRKLPSYQITDAIEDALSGLSWLQDHGFDGEQVVVAGDSAGGYLAFMTTLSAIRSHLAKPAGIATVSPFTDPDPARKLAHRNARRCSMFTCGALSMFARYLGEVQLPQDRPKSSRRVESPVDADLSPLPPVAIHASSDELLLADAELMAKRLTAAGIRCDLHLWDGQIHDFPLAADVLPEGRRAIRYLGDFVKEVTDGCAARTPAAAAG
>NC_022663.1|WP_036394264.1|6392043_6393486_+|serine/threonine-protein-kinase
MPLAEGSTFAGYTIVRQLGSGGMGEVYLARHPRLPRQDALKVLRPEVSADTEYRERFNREADAAASLWHPHIVAVHDRGETDGQLWIDMDYVDGVDAVRLLRERYPNGMPGPEVTAIITAVAEALDYAHEHKLLHRDVKPANILIAKPDSPDRRIMLADFGIAGWVGEASGLTATNMTVGTVSYAAPEQLMGQDLDGRADQYALAATAFHLLTGTPPFQHSNPAVVISQHLSASPPPIGDRLPALADLDPVFAKALAKDPKDRYQRCIDFARALGHRLGGGGDADETIARPVAVPVPPAKRSLVRPAVLIPALLAILLVIATLVALREFQRADDERVVSATTSGSPATTTTSAPTTSTTTTSTTTPPTTPSTTAAAQTETTTSAAPAPVVVIGAVCAPQGSTGLTKTGATAYCSTLQGTNTTIWSLTPGTVASPTIPATAEPTESPLPTEQESPIRICMQQTGQTRRQCREEIRRSNGWP
>NC_022663.1|WP_023374034.1|6393554_6394898_-|PPE-family-protein
MIAQIWMAWPPEAHSTTLSSGPGPGPLLAAADAWTSLSTEYADAAAELTVLLAGVQAADWQGPSAESYAAAHLPYVAWLTKASSDSLDAAAQHETVAAAYTSALAAMPTLGELAANHIAHAVLMATNFFGINAIPIALNEADYARMWVQAAVTMSVYAAVSGAALVAAPHTPPAPAIVKHHVGHVGSFPPPPKPPWWNIIWQLLETLAHVLTQALWELVSEVARFGVQMLFDLLQLVVAYVVLLAGYVLQMVKILNLLISDLLVLLLDQVQLVLIFLDITLRAAMAVVQQLAVFLGKVLGTLYWAVDNAAAAVAQAIRELLGGAAMAAEMVGVSPAVPQTGVATPLPMGGFATSPVALSAGIAPATGSAAHAAAAASSVAAQAGASGSSAGSEVLASESGAEISSIAGTAPDGAVLRPAGLTVLNSEFGGDVAVPMLPGTWDSSMAS
>NC_022663.1|WP_036394260.1|6395356_6395662_-|hypothetical-protein
MRPWKRPAAVLATAVLAFTAVPEVFAIMAPSAQANADVCVNAGRRVSVSGCANIADAVAPYVPPPSEYAPLPEDYPPPPPPAPNINVCANVGRRISVSGCV

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_022663_9	9.1\|3394618\|26\|NC_022663\|CRISPRCasFinder	3394618-3394643	26	NC_022663.1	3394679-3394704	0	1.0
NC_022663_14	14.1\|4891399\|47\|NC_022663\|CRT	4891399-4891445	47	NC_022663.1	4891909-4891955	0	1.0
NC_022663_14	14.1\|4891399\|47\|NC_022663\|CRT	4891399-4891445	47	NC_022663.1	4892788-4892834	0	1.0
NC_022663_14	14.1\|4891399\|47\|NC_022663\|CRT	4891399-4891445	47	NC_022663.1	4893298-4893344	0	1.0
NC_022663_14	14.2\|4891471\|47\|NC_022663\|CRT	4891471-4891517	47	NC_022663.1	4892278-4892324	0	1.0
NC_022663_14	14.2\|4891471\|47\|NC_022663\|CRT	4891471-4891517	47	NC_022663.1	4892860-4892906	0	1.0
NC_022663_14	14.3\|4891543\|47\|NC_022663\|CRT	4891543-4891589	47	NC_022663.1	4890736-4890782	0	1.0
NC_022663_14	14.3\|4891543\|47\|NC_022663\|CRT	4891543-4891589	47	NC_022663.1	4891033-4891079	0	1.0
NC_022663_14	14.3\|4891543\|47\|NC_022663\|CRT	4891543-4891589	47	NC_022663.1	4892056-4892102	0	1.0
NC_022663_14	14.3\|4891543\|47\|NC_022663\|CRT	4891543-4891589	47	NC_022663.1	4892350-4892396	0	1.0
NC_022663_14	14.5\|4891693\|47\|NC_022663\|CRT	4891693-4891739	47	NC_022663.1	4890520-4890566	0	1.0
NC_022663_14	14.5\|4891693\|47\|NC_022663\|CRT	4891693-4891739	47	NC_022663.1	4890886-4890932	0	1.0
NC_022663_14	14.5\|4891693\|47\|NC_022663\|CRT	4891693-4891739	47	NC_022663.1	4891183-4891229	0	1.0
NC_022663_14	14.5\|4891693\|47\|NC_022663\|CRT	4891693-4891739	47	NC_022663.1	4892206-4892252	0	1.0
NC_022663_14	14.5\|4891693\|47\|NC_022663\|CRT	4891693-4891739	47	NC_022663.1	4892572-4892618	0	1.0
NC_022663_14	14.5\|4891693\|47\|NC_022663\|CRT	4891693-4891739	47	NC_022663.1	4893082-4893128	0	1.0
NC_022663_14	14.6\|4891765\|47\|NC_022663\|CRT	4891765-4891811	47	NC_022663.1	4890592-4890638	0	1.0
NC_022663_14	14.6\|4891765\|47\|NC_022663\|CRT	4891765-4891811	47	NC_022663.1	4891255-4891301	0	1.0
NC_022663_14	14.6\|4891765\|47\|NC_022663\|CRT	4891765-4891811	47	NC_022663.1	4892644-4892690	0	1.0
NC_022663_14	14.6\|4891765\|47\|NC_022663\|CRT	4891765-4891811	47	NC_022663.1	4893154-4893200	0	1.0
NC_022663_15	15.1\|4892433\|37\|NC_022663\|PILER-CR	4892433-4892469	37	NC_022663.1	4890453-4890489	0	1.0
NC_022663_15	15.1\|4892433\|37\|NC_022663\|PILER-CR	4892433-4892469	37	NC_022663.1	4891116-4891152	0	1.0
NC_022663_15	15.1\|4892433\|37\|NC_022663\|PILER-CR	4892433-4892469	37	NC_022663.1	4892139-4892175	0	1.0
NC_022663_15	15.1\|4892433\|37\|NC_022663\|PILER-CR	4892433-4892469	37	NC_022663.1	4893015-4893051	0	1.0
NC_022663_15	15.2\|4892511\|31\|NC_022663\|PILER-CR	4892511-4892541	31	NC_022663.1	4890531-4890561	0	1.0
NC_022663_15	15.2\|4892511\|31\|NC_022663\|PILER-CR	4892511-4892541	31	NC_022663.1	4890897-4890927	0	1.0
NC_022663_15	15.2\|4892511\|31\|NC_022663\|PILER-CR	4892511-4892541	31	NC_022663.1	4891194-4891224	0	1.0
NC_022663_15	15.2\|4892511\|31\|NC_022663\|PILER-CR	4892511-4892541	31	NC_022663.1	4892217-4892247	0	1.0
NC_022663_15	15.2\|4892511\|31\|NC_022663\|PILER-CR	4892511-4892541	31	NC_022663.1	4892583-4892613	0	1.0
NC_022663_15	15.2\|4892511\|31\|NC_022663\|PILER-CR	4892511-4892541	31	NC_022663.1	4893093-4893123	0	1.0
NC_022663_7	7.7\|1763248\|18\|NC_022663\|CRT	1763248-1763265	18	NC_022663.1	3706646-3706663	1	0.944
NC_022663_7	7.11\|1763431\|18\|NC_022663\|CRT	1763431-1763448	18	NC_022663.1	5423148-5423165	1	0.944
NC_022663_8	8.6\|1947572\|17\|NC_022663\|CRISPRCasFinder	1947572-1947588	17	NC_022663.1	5803119-5803135	1	0.941
NC_022663_8	8.6\|1947572\|17\|NC_022663\|CRISPRCasFinder	1947572-1947588	17	NC_022654.1	62921-62937	1	0.941
NC_022663_14	14.3\|4891543\|47\|NC_022663\|CRT	4891543-4891589	47	NC_022663.1	4890370-4890416	1	0.979
NC_022663_14	14.3\|4891543\|47\|NC_022663\|CRT	4891543-4891589	47	NC_022663.1	4892932-4892978	1	0.979
NC_022663_4	4.2\|1067885\|22\|NC_022663\|CRISPRCasFinder	1067885-1067906	22	NC_022663.1	3839373-3839394	2	0.909
NC_022663_5	5.6\|1068326\|22\|NC_022663\|CRISPRCasFinder	1068326-1068347	22	NC_022663.1	2959746-2959767	2	0.909
NC_022663_7	7.2\|1762978\|27\|NC_022663\|CRT	1762978-1763004	27	NC_022663.1	2779788-2779814	2	0.926
NC_022663_7	7.9\|1763335\|18\|NC_022663\|CRT	1763335-1763352	18	NC_022654.1	117589-117606	2	0.889
NC_022663_7	7.15\|1763617\|21\|NC_022663\|CRT	1763617-1763637	21	NC_022663.1	3705290-3705310	2	0.905
NC_022663_14	14.4\|4891615\|53\|NC_022663\|CRT	4891615-4891667	53	NC_022663.1	4890442-4890494	2	0.962
NC_022663_14	14.4\|4891615\|53\|NC_022663\|CRT	4891615-4891667	53	NC_022663.1	4891105-4891157	2	0.962
NC_022663_14	14.4\|4891615\|53\|NC_022663\|CRT	4891615-4891667	53	NC_022663.1	4892128-4892180	2	0.962
NC_022663_14	14.4\|4891615\|53\|NC_022663\|CRT	4891615-4891667	53	NC_022663.1	4893004-4893056	2	0.962

1. spacer 9.1|3394618|26|NC_022663|CRISPRCasFinder matches to position: 3394679-3394704, mismatch: 0, identity: 1.0

ttgccgtatcgagcgtgcggtggtgc	CRISPR spacer
ttgccgtatcgagcgtgcggtggtgc	Protospacer
**************************

2. spacer 14.1|4891399|47|NC_022663|CRT matches to position: 4891909-4891955, mismatch: 0, identity: 1.0

caacgccaacaatggggtggcggccggtgcggatggcagcctcaaca	CRISPR spacer
caacgccaacaatggggtggcggccggtgcggatggcagcctcaaca	Protospacer
***********************************************

3. spacer 14.1|4891399|47|NC_022663|CRT matches to position: 4892788-4892834, mismatch: 0, identity: 1.0

caacgccaacaatggggtggcggccggtgcggatggcagcctcaaca	CRISPR spacer
caacgccaacaatggggtggcggccggtgcggatggcagcctcaaca	Protospacer
***********************************************

4. spacer 14.1|4891399|47|NC_022663|CRT matches to position: 4893298-4893344, mismatch: 0, identity: 1.0

caacgccaacaatggggtggcggccggtgcggatggcagcctcaaca	CRISPR spacer
caacgccaacaatggggtggcggccggtgcggatggcagcctcaaca	Protospacer
***********************************************

5. spacer 14.2|4891471|47|NC_022663|CRT matches to position: 4892278-4892324, mismatch: 0, identity: 1.0

tgccgacaatggtggggttgtggcggggtcgagcggtgacacgaaca	CRISPR spacer
tgccgacaatggtggggttgtggcggggtcgagcggtgacacgaaca	Protospacer
***********************************************

6. spacer 14.2|4891471|47|NC_022663|CRT matches to position: 4892860-4892906, mismatch: 0, identity: 1.0

tgccgacaatggtggggttgtggcggggtcgagcggtgacacgaaca	CRISPR spacer
tgccgacaatggtggggttgtggcggggtcgagcggtgacacgaaca	Protospacer
***********************************************

7. spacer 14.3|4891543|47|NC_022663|CRT matches to position: 4890736-4890782, mismatch: 0, identity: 1.0

ggatcgtaatgctggggtgttggccagtgcgcagggggtgcgcaata	CRISPR spacer
ggatcgtaatgctggggtgttggccagtgcgcagggggtgcgcaata	Protospacer
***********************************************

8. spacer 14.3|4891543|47|NC_022663|CRT matches to position: 4891033-4891079, mismatch: 0, identity: 1.0

ggatcgtaatgctggggtgttggccagtgcgcagggggtgcgcaata	CRISPR spacer
ggatcgtaatgctggggtgttggccagtgcgcagggggtgcgcaata	Protospacer
***********************************************

9. spacer 14.3|4891543|47|NC_022663|CRT matches to position: 4892056-4892102, mismatch: 0, identity: 1.0

ggatcgtaatgctggggtgttggccagtgcgcagggggtgcgcaata	CRISPR spacer
ggatcgtaatgctggggtgttggccagtgcgcagggggtgcgcaata	Protospacer
***********************************************

10. spacer 14.3|4891543|47|NC_022663|CRT matches to position: 4892350-4892396, mismatch: 0, identity: 1.0

ggatcgtaatgctggggtgttggccagtgcgcagggggtgcgcaata	CRISPR spacer
ggatcgtaatgctggggtgttggccagtgcgcagggggtgcgcaata	Protospacer
***********************************************

11. spacer 14.5|4891693|47|NC_022663|CRT matches to position: 4890520-4890566, mismatch: 0, identity: 1.0

tgatgccaatagtggggtggcggctagtgcggatggtcgtatcaatg	CRISPR spacer
tgatgccaatagtggggtggcggctagtgcggatggtcgtatcaatg	Protospacer
***********************************************

12. spacer 14.5|4891693|47|NC_022663|CRT matches to position: 4890886-4890932, mismatch: 0, identity: 1.0

tgatgccaatagtggggtggcggctagtgcggatggtcgtatcaatg	CRISPR spacer
tgatgccaatagtggggtggcggctagtgcggatggtcgtatcaatg	Protospacer
***********************************************

13. spacer 14.5|4891693|47|NC_022663|CRT matches to position: 4891183-4891229, mismatch: 0, identity: 1.0

tgatgccaatagtggggtggcggctagtgcggatggtcgtatcaatg	CRISPR spacer
tgatgccaatagtggggtggcggctagtgcggatggtcgtatcaatg	Protospacer
***********************************************

14. spacer 14.5|4891693|47|NC_022663|CRT matches to position: 4892206-4892252, mismatch: 0, identity: 1.0

tgatgccaatagtggggtggcggctagtgcggatggtcgtatcaatg	CRISPR spacer
tgatgccaatagtggggtggcggctagtgcggatggtcgtatcaatg	Protospacer
***********************************************

15. spacer 14.5|4891693|47|NC_022663|CRT matches to position: 4892572-4892618, mismatch: 0, identity: 1.0

tgatgccaatagtggggtggcggctagtgcggatggtcgtatcaatg	CRISPR spacer
tgatgccaatagtggggtggcggctagtgcggatggtcgtatcaatg	Protospacer
***********************************************

16. spacer 14.5|4891693|47|NC_022663|CRT matches to position: 4893082-4893128, mismatch: 0, identity: 1.0

tgatgccaatagtggggtggcggctagtgcggatggtcgtatcaatg	CRISPR spacer
tgatgccaatagtggggtggcggctagtgcggatggtcgtatcaatg	Protospacer
***********************************************

17. spacer 14.6|4891765|47|NC_022663|CRT matches to position: 4890592-4890638, mismatch: 0, identity: 1.0

tgatggcaatagtggagttacggcggatgcggatggcagtgtcaatg	CRISPR spacer
tgatggcaatagtggagttacggcggatgcggatggcagtgtcaatg	Protospacer
***********************************************

18. spacer 14.6|4891765|47|NC_022663|CRT matches to position: 4891255-4891301, mismatch: 0, identity: 1.0

tgatggcaatagtggagttacggcggatgcggatggcagtgtcaatg	CRISPR spacer
tgatggcaatagtggagttacggcggatgcggatggcagtgtcaatg	Protospacer
***********************************************

19. spacer 14.6|4891765|47|NC_022663|CRT matches to position: 4892644-4892690, mismatch: 0, identity: 1.0

tgatggcaatagtggagttacggcggatgcggatggcagtgtcaatg	CRISPR spacer
tgatggcaatagtggagttacggcggatgcggatggcagtgtcaatg	Protospacer
***********************************************

20. spacer 14.6|4891765|47|NC_022663|CRT matches to position: 4893154-4893200, mismatch: 0, identity: 1.0

tgatggcaatagtggagttacggcggatgcggatggcagtgtcaatg	CRISPR spacer
tgatggcaatagtggagttacggcggatgcggatggcagtgtcaatg	Protospacer
***********************************************

21. spacer 15.1|4892433|37|NC_022663|PILER-CR matches to position: 4890453-4890489, mismatch: 0, identity: 1.0

tgattgatgcggcgagtgcgatcgcggtgggggagac	CRISPR spacer
tgattgatgcggcgagtgcgatcgcggtgggggagac	Protospacer
*************************************

22. spacer 15.1|4892433|37|NC_022663|PILER-CR matches to position: 4891116-4891152, mismatch: 0, identity: 1.0

tgattgatgcggcgagtgcgatcgcggtgggggagac	CRISPR spacer
tgattgatgcggcgagtgcgatcgcggtgggggagac	Protospacer
*************************************

23. spacer 15.1|4892433|37|NC_022663|PILER-CR matches to position: 4892139-4892175, mismatch: 0, identity: 1.0

tgattgatgcggcgagtgcgatcgcggtgggggagac	CRISPR spacer
tgattgatgcggcgagtgcgatcgcggtgggggagac	Protospacer
*************************************

24. spacer 15.1|4892433|37|NC_022663|PILER-CR matches to position: 4893015-4893051, mismatch: 0, identity: 1.0

tgattgatgcggcgagtgcgatcgcggtgggggagac	CRISPR spacer
tgattgatgcggcgagtgcgatcgcggtgggggagac	Protospacer
*************************************

25. spacer 15.2|4892511|31|NC_022663|PILER-CR matches to position: 4890531-4890561, mismatch: 0, identity: 1.0

gtggggtggcggctagtgcggatggtcgtat	CRISPR spacer
gtggggtggcggctagtgcggatggtcgtat	Protospacer
*******************************

26. spacer 15.2|4892511|31|NC_022663|PILER-CR matches to position: 4890897-4890927, mismatch: 0, identity: 1.0

gtggggtggcggctagtgcggatggtcgtat	CRISPR spacer
gtggggtggcggctagtgcggatggtcgtat	Protospacer
*******************************

27. spacer 15.2|4892511|31|NC_022663|PILER-CR matches to position: 4891194-4891224, mismatch: 0, identity: 1.0

gtggggtggcggctagtgcggatggtcgtat	CRISPR spacer
gtggggtggcggctagtgcggatggtcgtat	Protospacer
*******************************

28. spacer 15.2|4892511|31|NC_022663|PILER-CR matches to position: 4892217-4892247, mismatch: 0, identity: 1.0

gtggggtggcggctagtgcggatggtcgtat	CRISPR spacer
gtggggtggcggctagtgcggatggtcgtat	Protospacer
*******************************

29. spacer 15.2|4892511|31|NC_022663|PILER-CR matches to position: 4892583-4892613, mismatch: 0, identity: 1.0

gtggggtggcggctagtgcggatggtcgtat	CRISPR spacer
gtggggtggcggctagtgcggatggtcgtat	Protospacer
*******************************

30. spacer 15.2|4892511|31|NC_022663|PILER-CR matches to position: 4893093-4893123, mismatch: 0, identity: 1.0

gtggggtggcggctagtgcggatggtcgtat	CRISPR spacer
gtggggtggcggctagtgcggatggtcgtat	Protospacer
*******************************

31. spacer 7.7|1763248|18|NC_022663|CRT matches to position: 3706646-3706663, mismatch: 1, identity: 0.944

gccggtgggctgttctcc	CRISPR spacer
gccggcgggctgttctcc	Protospacer
*****.************

32. spacer 7.11|1763431|18|NC_022663|CRT matches to position: 5423148-5423165, mismatch: 1, identity: 0.944

atgttcggcgcgggtggc	CRISPR spacer
atgttcggcgccggtggc	Protospacer
*********** ******

33. spacer 8.6|1947572|17|NC_022663|CRISPRCasFinder matches to position: 5803119-5803135, mismatch: 1, identity: 0.941

gcgggctgccggcgctg	CRISPR spacer
gcggggtgccggcgctg	Protospacer
***** ***********

34. spacer 8.6|1947572|17|NC_022663|CRISPRCasFinder matches to position: 62921-62937, mismatch: 1, identity: 0.941

gcgggctgccggcgctg	CRISPR spacer
gcgggctggcggcgctg	Protospacer
******** ********

35. spacer 14.3|4891543|47|NC_022663|CRT matches to position: 4890370-4890416, mismatch: 1, identity: 0.979

ggatcgtaatgctggggtgttggccagtgcgcagggggtgcgcaata	CRISPR spacer
ggatcgtaatgctggggtgttggccagttcgcagggggtgcgcaata	Protospacer
**************************** ******************

36. spacer 14.3|4891543|47|NC_022663|CRT matches to position: 4892932-4892978, mismatch: 1, identity: 0.979

ggatcgtaatgctggggtgttggccagtgcgcagggggtgcgcaata	CRISPR spacer
ggatcgtaatgctggggtgttggccagttcgcagggggtgcgcaata	Protospacer
**************************** ******************

37. spacer 4.2|1067885|22|NC_022663|CRISPRCasFinder matches to position: 3839373-3839394, mismatch: 2, identity: 0.909

gacggtacccgagttgaagaag	CRISPR spacer
gacgacacccgagttgaagaag	Protospacer
****..****************

38. spacer 5.6|1068326|22|NC_022663|CRISPRCasFinder matches to position: 2959746-2959767, mismatch: 2, identity: 0.909

gccgctgcccaagttgaacgag	CRISPR spacer
gccgctgcccatgttgagcgag	Protospacer
*********** *****.****

39. spacer 7.2|1762978|27|NC_022663|CRT matches to position: 2779788-2779814, mismatch: 2, identity: 0.926

gccgcagggctgatcggcaacggcggg	CRISPR spacer
gccgccggcctgatcggcaacggcggg	Protospacer
***** ** ******************

40. spacer 7.9|1763335|18|NC_022663|CRT matches to position: 117589-117606, mismatch: 2, identity: 0.889

accggcggaatgttcggc	CRISPR spacer
accggctgaatgttgggc	Protospacer
****** ******* ***

41. spacer 7.15|1763617|21|NC_022663|CRT matches to position: 3705290-3705310, mismatch: 2, identity: 0.905

atgttcttcggcgacggcggg	CRISPR spacer
atgttcatcggcaacggcggg	Protospacer
****** *****.********

42. spacer 14.4|4891615|53|NC_022663|CRT matches to position: 4890442-4890494, mismatch: 2, identity: 0.962

taatgacaatgtgattgatgtggccagtgcgatcgcggtgggggagaccaatg	CRISPR spacer
taatgacaatgtgattgatgcggcgagtgcgatcgcggtgggggagaccaatg	Protospacer
********************.*** ****************************

43. spacer 14.4|4891615|53|NC_022663|CRT matches to position: 4891105-4891157, mismatch: 2, identity: 0.962

taatgacaatgtgattgatgtggccagtgcgatcgcggtgggggagaccaatg	CRISPR spacer
taatgacaatgtgattgatgcggcgagtgcgatcgcggtgggggagaccaatg	Protospacer
********************.*** ****************************

44. spacer 14.4|4891615|53|NC_022663|CRT matches to position: 4892128-4892180, mismatch: 2, identity: 0.962

taatgacaatgtgattgatgtggccagtgcgatcgcggtgggggagaccaatg	CRISPR spacer
taatgacaatgtgattgatgcggcgagtgcgatcgcggtgggggagaccaatg	Protospacer
********************.*** ****************************

45. spacer 14.4|4891615|53|NC_022663|CRT matches to position: 4893004-4893056, mismatch: 2, identity: 0.962

taatgacaatgtgattgatgtggccagtgcgatcgcggtgggggagaccaatg	CRISPR spacer
taatgacaatgtgattgatgcggcgagtgcgatcgcggtgggggagaccaatg	Protospacer
********************.*** ****************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_022663_1	1.2\|466806\|21\|NC_022663\|CRISPRCasFinder	466806-466826	21	NZ_AP018921	Pseudonocardia autotrophica strain NBRC 12743 plasmid pPA12743CP, complete sequence	160370-160390	1	0.952
NC_022663_5	5.1\|1068056\|22\|NC_022663\|CRISPRCasFinder	1068056-1068077	22	NC_015595	Sphingobium chlorophenolicum L-1 plasmid pSPHCH01, complete sequence	87401-87422	2	0.909
NC_022663_5	5.6\|1068326\|22\|NC_022663\|CRISPRCasFinder	1068326-1068347	22	NC_022044	Paracoccus aminophilus JCM 7686 plasmid pAMI6, complete sequence	191530-191551	2	0.909
NC_022663_6	6.2\|1533199\|23\|NC_022663\|CRISPRCasFinder	1533199-1533221	23	NZ_CP031358	Erythrobacter aureus strain YH-07 plasmid unnamed, complete sequence	66249-66271	2	0.913
NC_022663_7	7.4\|1763101\|24\|NC_022663\|CRT	1763101-1763124	24	CP040467	Streptomyces albidoflavus strain UYFA156 plasmid unnamed, complete sequence	243586-243609	2	0.917
NC_022663_3	3.1\|1067690\|22\|NC_022663\|CRISPRCasFinder	1067690-1067711	22	NZ_CP021827	Sinorhizobium meliloti strain KH35c plasmid psymA, complete sequence	386300-386321	3	0.864
NC_022663_4	4.1\|1067840\|22\|NC_022663\|CRISPRCasFinder	1067840-1067861	22	NZ_CP026518	Deinococcus sp. NW-56 plasmid unnamed2, complete sequence	105479-105500	3	0.864
NC_022663_6	6.1\|1533151\|23\|NC_022663\|CRISPRCasFinder	1533151-1533173	23	NZ_CP033971	Cupriavidus pauculus strain FDAARGOS_614 plasmid unnamed2, complete sequence	266829-266851	3	0.87
NC_022663_6	6.1\|1533151\|23\|NC_022663\|CRISPRCasFinder	1533151-1533173	23	NC_011758	Methylorubrum extorquens CM4 plasmid pCMU01, complete sequence	306629-306651	3	0.87
NC_022663_7	7.1\|1762933\|27\|NC_022663\|CRT	1762933-1762959	27	NZ_LN831788	Streptomyces leeuwenhoekii strain type strain (C34 = DSM 42122 = NRRL B-24963) plasmid pSLE1, complete sequence	74821-74847	3	0.889
NC_022663_7	7.1\|1762933\|27\|NC_022663\|CRT	1762933-1762959	27	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	2210875-2210901	4	0.852
NC_022663_7	7.1\|1762933\|27\|NC_022663\|CRT	1762933-1762959	27	NC_019957	Mycobacterium sp. JS623 plasmid pMYCSM01, complete sequence	283819-283845	4	0.852
NC_022663_7	7.1\|1762933\|27\|NC_022663\|CRT	1762933-1762959	27	NZ_CP053436	Spirosoma sp. TS118 plasmid pTS, complete sequence	2057-2083	4	0.852
NC_022663_7	7.1\|1762933\|27\|NC_022663\|CRT	1762933-1762959	27	AB983711	Ralstonia phage RSJ5 DNA, complete genome	39433-39459	4	0.852
NC_022663_7	7.2\|1762978\|27\|NC_022663\|CRT	1762978-1763004	27	NZ_CP032340	Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence	957319-957345	4	0.852
NC_022663_7	7.2\|1762978\|27\|NC_022663\|CRT	1762978-1763004	27	NC_007336	Cupriavidus pinatubonensis JMP134 megaplasmid, complete sequence	469113-469139	4	0.852
NC_022663_7	7.2\|1762978\|27\|NC_022663\|CRT	1762978-1763004	27	NZ_CP012915	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence	1175061-1175087	4	0.852
NC_022663_9	9.1\|3394618\|26\|NC_022663\|CRISPRCasFinder	3394618-3394643	26	NC_022536	Rhizobium sp. IRBG74 plasmid IRBL74_p, complete sequence	484086-484111	4	0.846
NC_022663_9	9.1\|3394618\|26\|NC_022663\|CRISPRCasFinder	3394618-3394643	26	NZ_CP023068	Ensifer sojae CCBAU 05684 plasmid pSJ05684b, complete sequence	974316-974341	4	0.846
NC_022663_18	18.1\|5470334\|25\|NC_022663\|CRISPRCasFinder	5470334-5470358	25	NZ_CP045074	Paracoccus kondratievae strain BJQ0001 plasmid unnamed1, complete sequence	373525-373549	4	0.84
NC_022663_18	18.1\|5470334\|25\|NC_022663\|CRISPRCasFinder	5470334-5470358	25	NZ_CP013528	Rhizobium phaseoli strain R723 plasmid pRphaR723a, complete sequence	46228-46252	4	0.84
NC_022663_18	18.1\|5470334\|25\|NC_022663\|CRISPRCasFinder	5470334-5470358	25	NZ_CP013538	Rhizobium phaseoli strain R630 plasmid pRphaR630a, complete sequence	46229-46253	4	0.84
NC_022663_18	18.1\|5470334\|25\|NC_022663\|CRISPRCasFinder	5470334-5470358	25	NZ_CP013581	Rhizobium phaseoli strain N261 plasmid pRphaN261a, complete sequence	46228-46252	4	0.84
NC_022663_7	7.1\|1762933\|27\|NC_022663\|CRT	1762933-1762959	27	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	2209966-2209992	5	0.815
NC_022663_7	7.1\|1762933\|27\|NC_022663\|CRT	1762933-1762959	27	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	3050213-3050239	5	0.815
NC_022663_7	7.1\|1762933\|27\|NC_022663\|CRT	1762933-1762959	27	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	350824-350850	5	0.815
NC_022663_7	7.1\|1762933\|27\|NC_022663\|CRT	1762933-1762959	27	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	4647520-4647546	5	0.815
NC_022663_7	7.1\|1762933\|27\|NC_022663\|CRT	1762933-1762959	27	NC_011879	Pseudarthrobacter chlorophenolicus A6 plasmid pACHL01, complete sequence	98276-98302	5	0.815
NC_022663_7	7.1\|1762933\|27\|NC_022663\|CRT	1762933-1762959	27	MG812496	Gordonia phage SallySpecial, complete genome	11628-11654	5	0.815
NC_022663_7	7.1\|1762933\|27\|NC_022663\|CRT	1762933-1762959	27	MG812496	Gordonia phage SallySpecial, complete genome	11637-11663	5	0.815
NC_022663_7	7.1\|1762933\|27\|NC_022663\|CRT	1762933-1762959	27	NC_042031	Mycobacterium phage Anaya, complete sequence	7769-7795	5	0.815
NC_022663_7	7.1\|1762933\|27\|NC_022663\|CRT	1762933-1762959	27	NC_007336	Cupriavidus pinatubonensis JMP134 megaplasmid, complete sequence	434453-434479	5	0.815
NC_022663_7	7.1\|1762933\|27\|NC_022663\|CRT	1762933-1762959	27	KX344445	Streptomyces phage Nanodon, complete genome	17730-17756	5	0.815
NC_022663_7	7.1\|1762933\|27\|NC_022663\|CRT	1762933-1762959	27	NZ_CP044425	Paracoccus pantotrophus strain DSM 2944 plasmid pPAN2, complete sequence	207089-207115	5	0.815
NC_022663_7	7.2\|1762978\|27\|NC_022663\|CRT	1762978-1763004	27	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	2209495-2209521	5	0.815
NC_022663_7	7.2\|1762978\|27\|NC_022663\|CRT	1762978-1763004	27	NZ_CP022191	Yangia pacifica strain YSBP01 plasmid unnamed1, complete sequence	194340-194366	5	0.815
NC_022663_7	7.2\|1762978\|27\|NC_022663\|CRT	1762978-1763004	27	NZ_CP021026	Rhizobium sp. TAL182 plasmid pRetTAL182b, complete sequence	130042-130068	5	0.815
NC_022663_7	7.2\|1762978\|27\|NC_022663\|CRT	1762978-1763004	27	NZ_CP013597	Rhizobium sp. N741 plasmid pRspN741b, complete sequence	163335-163361	5	0.815
NC_022663_7	7.2\|1762978\|27\|NC_022663\|CRT	1762978-1763004	27	NZ_CP013501	Rhizobium esperanzae strain N561 plasmid pRspN561a, complete sequence	163701-163727	5	0.815
NC_022663_7	7.2\|1762978\|27\|NC_022663\|CRT	1762978-1763004	27	NZ_CP013507	Rhizobium sp. N1341 plasmid pRspN1341b, complete sequence	163335-163361	5	0.815
NC_022663_7	7.2\|1762978\|27\|NC_022663\|CRT	1762978-1763004	27	NZ_CP013518	Rhizobium sp. N113 plasmid pRspN113a, complete sequence	163701-163727	5	0.815
NC_022663_7	7.2\|1762978\|27\|NC_022663\|CRT	1762978-1763004	27	NZ_CP013491	Rhizobium sp. N6212 plasmid pRspN6212a, complete sequence	163704-163730	5	0.815
NC_022663_7	7.2\|1762978\|27\|NC_022663\|CRT	1762978-1763004	27	NZ_CP013513	Rhizobium sp. N1314 plasmid pRspN1314b, complete sequence	184586-184612	5	0.815
NC_022663_7	7.2\|1762978\|27\|NC_022663\|CRT	1762978-1763004	27	NZ_CP013496	Rhizobium sp. N621 plasmid pRspN621a, complete sequence	163704-163730	5	0.815
NC_022663_7	7.2\|1762978\|27\|NC_022663\|CRT	1762978-1763004	27	NZ_CP013591	Rhizobium sp. N871 plasmid pRspN871a, complete sequence	163704-163730	5	0.815
NC_022663_7	7.2\|1762978\|27\|NC_022663\|CRT	1762978-1763004	27	NZ_CP013603	Rhizobium sp. N731 plasmid pRspN731b, complete sequence	184586-184612	5	0.815
NC_022663_7	7.2\|1762978\|27\|NC_022663\|CRT	1762978-1763004	27	NZ_CP029357	Azospirillum sp. CFH 70021 plasmid unnamed2	454207-454233	5	0.815
NC_022663_7	7.1\|1762933\|27\|NC_022663\|CRT	1762933-1762959	27	AB920995	Ralstonia phage RSJ2 DNA, complete genome	40305-40331	6	0.778
NC_022663_7	7.1\|1762933\|27\|NC_022663\|CRT	1762933-1762959	27	NZ_CP039340	Ralstonia solanacearum strain UW386 plasmid pUW386, complete sequence	110677-110703	6	0.778
NC_022663_7	7.1\|1762933\|27\|NC_022663\|CRT	1762933-1762959	27	MN234174	Mycobacterium phage Efra2, complete genome	6710-6736	6	0.778
NC_022663_7	7.1\|1762933\|27\|NC_022663\|CRT	1762933-1762959	27	MN234165	Mycobacterium phage Yunkel11, complete genome	6726-6752	6	0.778
NC_022663_7	7.1\|1762933\|27\|NC_022663\|CRT	1762933-1762959	27	MT701598	Streptomyces phage Sitrop, complete genome	15722-15748	6	0.778
NC_022663_7	7.1\|1762933\|27\|NC_022663\|CRT	1762933-1762959	27	JN698995	Mycobacterium phage Dori, complete genome	28155-28181	6	0.778
NC_022663_7	7.1\|1762933\|27\|NC_022663\|CRT	1762933-1762959	27	MN234201	Mycobacterium phage Guanica15, complete genome	6726-6752	6	0.778
NC_022663_7	7.1\|1762933\|27\|NC_022663\|CRT	1762933-1762959	27	MH669013	Gordonia phage Skysand, complete genome	37141-37167	6	0.778
NC_022663_7	7.1\|1762933\|27\|NC_022663\|CRT	1762933-1762959	27	MF919542	Gordonia phage Patio, complete genome	36921-36947	6	0.778
NC_022663_7	7.1\|1762933\|27\|NC_022663\|CRT	1762933-1762959	27	MK977699	Gordonia Phage Lollipop1437, complete genome	37685-37711	6	0.778
NC_022663_7	7.12\|1763467\|30\|NC_022663\|CRT	1763467-1763496	30	NZ_CP011122	Acetobacter oryzifermentans strain SLV-7 plasmid unnamed2, complete sequence	88815-88844	6	0.8
NC_022663_7	7.12\|1763467\|30\|NC_022663\|CRT	1763467-1763496	30	NZ_CP023190	Acetobacter pomorum strain SH plasmid pSH1, complete sequence	31412-31441	6	0.8
NC_022663_7	7.12\|1763467\|30\|NC_022663\|CRT	1763467-1763496	30	NZ_CP042809	Acetobacter oryzoeni strain B6 plasmid unnamed1, complete sequence	235374-235403	6	0.8
NC_022663_7	7.12\|1763467\|30\|NC_022663\|CRT	1763467-1763496	30	NZ_AP014882	Acetobacter pasteurianus NBRC 101655 plasmid plasmid1 DNA, complete genome	55965-55994	6	0.8
NC_022663_7	7.12\|1763467\|30\|NC_022663\|CRT	1763467-1763496	30	NC_021976	Acetobacter pasteurianus 386B plasmid Apa386Bp1, complete sequence	115603-115632	6	0.8
NC_022663_7	7.16\|1763656\|30\|NC_022663\|CRT	1763656-1763685	30	MT023084	Citrobacter phage IME-JL8, complete genome	34052-34081	6	0.8
NC_022663_9	9.1\|3394618\|26\|NC_022663\|CRISPRCasFinder	3394618-3394643	26	NZ_CP021405	Celeribacter manganoxidans strain DY25 plasmid pDY25-A, complete sequence	95507-95532	6	0.769
NC_022663_13	13.3\|4888393\|34\|NC_022663\|PILER-CR	4888393-4888426	34	NC_042345	Phage Salvo, complete genome	21600-21633	6	0.824
NC_022663_15	15.2\|4892511\|31\|NC_022663\|PILER-CR	4892511-4892541	31	NC_019366	Paracoccus aestuarii plasmid pAES7, complete sequence	6260-6290	6	0.806
NC_022663_19	19.1\|5936365\|29\|NC_022663\|CRISPRCasFinder	5936365-5936393	29	MN693744	Marine virus AFVG_250M180, complete genome	6920-6948	6	0.793
NC_022663_19	19.1\|5936365\|29\|NC_022663\|CRISPRCasFinder	5936365-5936393	29	NC_010625	Paraburkholderia phymatum STM815 plasmid pBPHY01, complete sequence	1167856-1167884	6	0.793
NC_022663_7	7.6\|1763200\|30\|NC_022663\|CRT	1763200-1763229	30	NZ_CP025613	Niveispirillum cyanobacteriorum strain TH16 plasmid unnamed1, complete sequence	479003-479032	7	0.767
NC_022663_7	7.6\|1763200\|30\|NC_022663\|CRT	1763200-1763229	30	NC_010333	Caulobacter sp. K31 plasmid pCAUL02, complete sequence	174946-174975	7	0.767
NC_022663_19	19.1\|5936365\|29\|NC_022663\|CRISPRCasFinder	5936365-5936393	29	NZ_AP014579	Burkholderia sp. RPE67 plasmid p1, complete sequence	1260561-1260589	7	0.759
NC_022663_19	19.1\|5936365\|29\|NC_022663\|CRISPRCasFinder	5936365-5936393	29	NC_016626	Burkholderia sp. YI23 plasmid byi_1p, complete sequence	1112779-1112807	7	0.759
NC_022663_19	19.1\|5936365\|29\|NC_022663\|CRISPRCasFinder	5936365-5936393	29	NC_013193	Candidatus Accumulibacter phosphatis clade IIA str. UW-1 plasmid pAph01, complete sequence	160941-160969	7	0.759
NC_022663_7	7.6\|1763200\|30\|NC_022663\|CRT	1763200-1763229	30	NZ_CP022191	Yangia pacifica strain YSBP01 plasmid unnamed1, complete sequence	464900-464929	8	0.733
NC_022663_7	7.6\|1763200\|30\|NC_022663\|CRT	1763200-1763229	30	NZ_CP014599	Yangia sp. CCB-MM3 plasmid unnamed3, complete sequence	250309-250338	8	0.733
NC_022663_7	7.6\|1763200\|30\|NC_022663\|CRT	1763200-1763229	30	NC_028827	Streptomyces phage Lannister, complete genome	42714-42743	8	0.733
NC_022663_7	7.6\|1763200\|30\|NC_022663\|CRT	1763200-1763229	30	NC_014309	Ralstonia solanacearum CFBP2957 plasmid RCFBPv3_mp, complete genome	400752-400781	8	0.733
NC_022663_7	7.6\|1763200\|30\|NC_022663\|CRT	1763200-1763229	30	NZ_CP021767	Ralstonia solanacearum strain RS 489 plasmid unnamed, complete sequence	261408-261437	8	0.733
NC_022663_7	7.6\|1763200\|30\|NC_022663\|CRT	1763200-1763229	30	NZ_CP021765	Ralstonia pseudosolanacearum strain CRMRs218 plasmid unnamed, complete sequence	438514-438543	8	0.733
NC_022663_7	7.16\|1763656\|30\|NC_022663\|CRT	1763656-1763685	30	MK448878	Streptococcus phage Javan224, complete genome	33140-33169	8	0.733
NC_022663_7	7.16\|1763656\|30\|NC_022663\|CRT	1763656-1763685	30	NZ_CP010612	Phaeobacter inhibens strain P92 plasmid pP92_b, complete sequence	205404-205433	8	0.733
NC_022663_7	7.16\|1763656\|30\|NC_022663\|CRT	1763656-1763685	30	NZ_CP010630	Phaeobacter inhibens strain P78 plasmid pP78_a, complete sequence	234846-234875	8	0.733
NC_022663_7	7.16\|1763656\|30\|NC_022663\|CRT	1763656-1763685	30	NZ_CP010600	Phaeobacter inhibens strain P83 plasmid pP83_a, complete sequence	205950-205979	8	0.733
NC_022663_7	7.16\|1763656\|30\|NC_022663\|CRT	1763656-1763685	30	NZ_CP010726	Phaeobacter inhibens strain P88 plasmid pP88_a, complete sequence	205945-205974	8	0.733
NC_022663_7	7.16\|1763656\|30\|NC_022663\|CRT	1763656-1763685	30	NZ_CP010706	Phaeobacter inhibens strain P66 plasmid pP66_a, complete sequence	205950-205979	8	0.733
NC_022663_7	7.16\|1763656\|30\|NC_022663\|CRT	1763656-1763685	30	CP006880	Rhizobium gallicum bv. gallicum R602 plasmid pRgalR602c, complete sequence	332394-332423	8	0.733
NC_022663_7	7.16\|1763656\|30\|NC_022663\|CRT	1763656-1763685	30	NZ_CP019308	Phaeobacter inhibens strain DOK1-1 plasmid pDOK1-1-1, complete sequence	49087-49116	8	0.733
NC_022663_7	7.16\|1763656\|30\|NC_022663\|CRT	1763656-1763685	30	NZ_CP010736	Phaeobacter inhibens strain P72 plasmid pP72_a, complete sequence	205975-206004	8	0.733
NC_022663_7	7.16\|1763656\|30\|NC_022663\|CRT	1763656-1763685	30	NC_018853	Streptomyce phage TG1, complete genome	11499-11528	8	0.733
NC_022663_7	7.16\|1763656\|30\|NC_022663\|CRT	1763656-1763685	30	JX182372	Streptomyces virus TG1, complete genome	11499-11528	8	0.733
NC_022663_8	8.1\|1947314\|32\|NC_022663\|CRISPRCasFinder	1947314-1947345	32	NC_007974	Cupriavidus metallidurans CH34 megaplasmid, complete sequence	1035884-1035915	8	0.75
NC_022663_8	8.1\|1947314\|32\|NC_022663\|CRISPRCasFinder	1947314-1947345	32	NZ_CP046333	Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3	2401522-2401553	8	0.75
NC_022663_7	7.6\|1763200\|30\|NC_022663\|CRT	1763200-1763229	30	NZ_CP021355	Rhodococcus sp. S2-17 plasmid pRB98, complete sequence	982772-982801	9	0.7
NC_022663_8	8.1\|1947314\|32\|NC_022663\|CRISPRCasFinder	1947314-1947345	32	NZ_CP045296	Paenibacillus cellulositrophicus strain KACC 16577 plasmid unnamed1, complete sequence	213670-213701	9	0.719
NC_022663_8	8.1\|1947314\|32\|NC_022663\|CRISPRCasFinder	1947314-1947345	32	NZ_CP015882	Ensifer adhaerens strain Casida A plasmid pCasidaAB, complete sequence	441605-441636	9	0.719
NC_022663_8	8.1\|1947314\|32\|NC_022663\|CRISPRCasFinder	1947314-1947345	32	NZ_CP030264	Ensifer adhaerens strain Corn53 plasmid AB, complete sequence	523667-523698	9	0.719
NC_022663_15	15.2\|4892511\|31\|NC_022663\|PILER-CR	4892511-4892541	31	NZ_LR594669	Variovorax sp. SRS16 plasmid 4	251316-251346	9	0.71
NC_022663_15	15.2\|4892511\|31\|NC_022663\|PILER-CR	4892511-4892541	31	NZ_LR594673	Variovorax sp. PBL-E5 plasmid 3	233980-234010	9	0.71
NC_022663_5	5.3\|1068161\|37\|NC_022663\|CRISPRCasFinder	1068161-1068197	37	KJ025957	Serratia phage PS2, complete genome	153545-153581	10	0.73
NC_022663_5	5.5\|1068266\|37\|NC_022663\|CRISPRCasFinder	1068266-1068302	37	NZ_CP014361	Methylomonas sp. DH-1 plasmid, complete sequence	11851-11887	10	0.73
NC_022663_7	7.12\|1763467\|30\|NC_022663\|CRT	1763467-1763496	30	NZ_CP017887	Pseudomonas frederiksbergensis strain ERDD5:01 plasmid unnamed1, complete sequence	301086-301115	10	0.667
NC_022663_8	8.1\|1947314\|32\|NC_022663\|CRISPRCasFinder	1947314-1947345	32	NZ_CP022367	Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence	1609319-1609350	10	0.688
NC_022663_13	13.3\|4888393\|34\|NC_022663\|PILER-CR	4888393-4888426	34	NZ_CP019438	Thioclava nitratireducens strain 25B10_4 plasmid unnamed1, complete sequence	66318-66351	10	0.706
NC_022663_13	13.3\|4888393\|34\|NC_022663\|PILER-CR	4888393-4888426	34	NZ_CP032340	Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence	595297-595330	10	0.706
NC_022663_13	13.3\|4888393\|34\|NC_022663\|PILER-CR	4888393-4888426	34	NZ_CP012915	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence	1537087-1537120	10	0.706
NC_022663_13	13.3\|4888393\|34\|NC_022663\|PILER-CR	4888393-4888426	34	NC_047910	Faecalibacterium phage FP_Epona, complete genome	18320-18353	10	0.706
NC_022663_15	15.1\|4892433\|37\|NC_022663\|PILER-CR	4892433-4892469	37	NZ_LR594664	Variovorax sp. RA8 plasmid 3	386557-386593	10	0.73
NC_022663_5	5.5\|1068266\|37\|NC_022663\|CRISPRCasFinder	1068266-1068302	37	NZ_CP014361	Methylomonas sp. DH-1 plasmid, complete sequence	14306-14342	11	0.703
NC_022663_8	8.1\|1947314\|32\|NC_022663\|CRISPRCasFinder	1947314-1947345	32	NZ_CP032322	Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence	76896-76927	11	0.656
NC_022663_8	8.1\|1947314\|32\|NC_022663\|CRISPRCasFinder	1947314-1947345	32	NZ_CP007794	Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence	1056098-1056129	11	0.656
NC_022663_8	8.1\|1947314\|32\|NC_022663\|CRISPRCasFinder	1947314-1947345	32	NZ_CP032340	Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence	1525045-1525076	11	0.656
NC_022663_8	8.1\|1947314\|32\|NC_022663\|CRISPRCasFinder	1947314-1947345	32	NZ_CP032346	Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence	68158-68189	11	0.656
NC_022663_8	8.1\|1947314\|32\|NC_022663\|CRISPRCasFinder	1947314-1947345	32	NZ_CP012915	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence	607322-607353	11	0.656

1. spacer 1.2|466806|21|NC_022663|CRISPRCasFinder matches to NZ_AP018921 (Pseudonocardia autotrophica strain NBRC 12743 plasmid pPA12743CP, complete sequence) position: , mismatch: 1, identity: 0.952

ccgtattggccgggctgggcc	CRISPR spacer
ccgtactggccgggctgggcc	Protospacer
*****.***************

2. spacer 5.1|1068056|22|NC_022663|CRISPRCasFinder matches to NC_015595 (Sphingobium chlorophenolicum L-1 plasmid pSPHCH01, complete sequence) position: , mismatch: 2, identity: 0.909

accgaagccgacgttgctactc	CRISPR spacer
tccgaagccgacgttgcgactc	Protospacer
 **************** ****

3. spacer 5.6|1068326|22|NC_022663|CRISPRCasFinder matches to NC_022044 (Paracoccus aminophilus JCM 7686 plasmid pAMI6, complete sequence) position: , mismatch: 2, identity: 0.909

gccgctgcccaagttgaacgag	CRISPR spacer
accgctgcccaaattgaacgag	Protospacer
.***********.*********

4. spacer 6.2|1533199|23|NC_022663|CRISPRCasFinder matches to NZ_CP031358 (Erythrobacter aureus strain YH-07 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.913

agggtgccggcgacggtatcccg	CRISPR spacer
agcgtgccggcgacgttatcccg	Protospacer
** ************ *******

5. spacer 7.4|1763101|24|NC_022663|CRT matches to CP040467 (Streptomyces albidoflavus strain UYFA156 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.917

gccggcgggggctcgatccagggg	CRISPR spacer
gccggcgcgggctcgatccagtgg	Protospacer
******* ************* **

6. spacer 3.1|1067690|22|NC_022663|CRISPRCasFinder matches to NZ_CP021827 (Sinorhizobium meliloti strain KH35c plasmid psymA, complete sequence) position: , mismatch: 3, identity: 0.864

accgaagctggtgttcgagttg	CRISPR spacer
gccgaagctggtgttcgagtct	Protospacer
.*******************.

7. spacer 4.1|1067840|22|NC_022663|CRISPRCasFinder matches to NZ_CP026518 (Deinococcus sp. NW-56 plasmid unnamed2, complete sequence) position: , mismatch: 3, identity: 0.864

cccgaagcccgtgttccccacg	CRISPR spacer
tgtgaagcccgtgttccccacg	Protospacer
. .*******************

8. spacer 6.1|1533151|23|NC_022663|CRISPRCasFinder matches to NZ_CP033971 (Cupriavidus pauculus strain FDAARGOS_614 plasmid unnamed2, complete sequence) position: , mismatch: 3, identity: 0.87

taccggccggcaacggcggcgca	CRISPR spacer
caccggccggcaacggctgcgcg	Protospacer
.**************** ****.

9. spacer 6.1|1533151|23|NC_022663|CRISPRCasFinder matches to NC_011758 (Methylorubrum extorquens CM4 plasmid pCMU01, complete sequence) position: , mismatch: 3, identity: 0.87

taccggccggcaacggcggcgca	CRISPR spacer
gaccggccggctacggcggcgcg	Protospacer
 ********** **********.

10. spacer 7.1|1762933|27|NC_022663|CRT matches to NZ_LN831788 (Streptomyces leeuwenhoekii strain type strain (C34 = DSM 42122 = NRRL B-24963) plasmid pSLE1, complete sequence) position: , mismatch: 3, identity: 0.889

tccggagccaccggcgccaacggcgga	CRISPR spacer
accgaagtcaccggcgccaacggcgga	Protospacer
 ***.**.*******************

11. spacer 7.1|1762933|27|NC_022663|CRT matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 4, identity: 0.852

tccggagccaccggcgccaacggcgga	CRISPR spacer
accggaggcaccggcggcaacggcggc	Protospacer
 ****** ******** *********

12. spacer 7.1|1762933|27|NC_022663|CRT matches to NC_019957 (Mycobacterium sp. JS623 plasmid pMYCSM01, complete sequence) position: , mismatch: 4, identity: 0.852

tccggagccaccggcgccaacggcgga	CRISPR spacer
accggaggcaccggcggcaacggcggc	Protospacer
 ****** ******** *********

13. spacer 7.1|1762933|27|NC_022663|CRT matches to NZ_CP053436 (Spirosoma sp. TS118 plasmid pTS, complete sequence) position: , mismatch: 4, identity: 0.852

tccggagccaccggcgccaacggcgga	CRISPR spacer
tccggagctacctgcgccaacggctgc	Protospacer
********.*** *********** *

14. spacer 7.1|1762933|27|NC_022663|CRT matches to AB983711 (Ralstonia phage RSJ5 DNA, complete genome) position: , mismatch: 4, identity: 0.852

tccggagccaccggcgccaacggcgga	CRISPR spacer
tgcagagccaccggccccaacggcggc	Protospacer
* *.*********** **********

15. spacer 7.2|1762978|27|NC_022663|CRT matches to NZ_CP032340 (Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence) position: , mismatch: 4, identity: 0.852

gccgcagggctgatcggcaacggcggg	CRISPR spacer
gctgaagggctgatcggcaacggctgt	Protospacer
**.* ******************* *

16. spacer 7.2|1762978|27|NC_022663|CRT matches to NC_007336 (Cupriavidus pinatubonensis JMP134 megaplasmid, complete sequence) position: , mismatch: 4, identity: 0.852

gccgcagggctgatcggcaacggcggg	CRISPR spacer
acctcagggctgatcggcaatggcgcg	Protospacer
.** ****************.**** *

17. spacer 7.2|1762978|27|NC_022663|CRT matches to NZ_CP012915 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence) position: , mismatch: 4, identity: 0.852

gccgcagggctgatcggcaacggcggg	CRISPR spacer
gctgaagggctgatcggcaacggctgt	Protospacer
**.* ******************* *

18. spacer 9.1|3394618|26|NC_022663|CRISPRCasFinder matches to NC_022536 (Rhizobium sp. IRBG74 plasmid IRBL74_p, complete sequence) position: , mismatch: 4, identity: 0.846

ttgccgtatcgagcgtgcggtggtgc	CRISPR spacer
cggccgtttcgagcgtgcggcggtgc	Protospacer
. ***** ************.*****

19. spacer 9.1|3394618|26|NC_022663|CRISPRCasFinder matches to NZ_CP023068 (Ensifer sojae CCBAU 05684 plasmid pSJ05684b, complete sequence) position: , mismatch: 4, identity: 0.846

ttgccgtatcgagcgtgcggtggtgc	CRISPR spacer
attccctatcgagcgtgcggtggtcc	Protospacer
 * ** ****************** *

20. spacer 18.1|5470334|25|NC_022663|CRISPRCasFinder matches to NZ_CP045074 (Paracoccus kondratievae strain BJQ0001 plasmid unnamed1, complete sequence) position: , mismatch: 4, identity: 0.84

tctgatggccgggctcctcaccggg	CRISPR spacer
gctgctggccgggatcctcaccggc	Protospacer
 *** ******** **********

21. spacer 18.1|5470334|25|NC_022663|CRISPRCasFinder matches to NZ_CP013528 (Rhizobium phaseoli strain R723 plasmid pRphaR723a, complete sequence) position: , mismatch: 4, identity: 0.84

tctgatggccgggctcctcaccggg	CRISPR spacer
gctgctggccgtgctcctcaccggc	Protospacer
 *** ****** ************

22. spacer 18.1|5470334|25|NC_022663|CRISPRCasFinder matches to NZ_CP013538 (Rhizobium phaseoli strain R630 plasmid pRphaR630a, complete sequence) position: , mismatch: 4, identity: 0.84

tctgatggccgggctcctcaccggg	CRISPR spacer
gctgctggccgtgctcctcaccggc	Protospacer
 *** ****** ************

23. spacer 18.1|5470334|25|NC_022663|CRISPRCasFinder matches to NZ_CP013581 (Rhizobium phaseoli strain N261 plasmid pRphaN261a, complete sequence) position: , mismatch: 4, identity: 0.84

tctgatggccgggctcctcaccggg	CRISPR spacer
gctgctggccgtgctcctcaccggc	Protospacer
 *** ****** ************

24. spacer 7.1|1762933|27|NC_022663|CRT matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 5, identity: 0.815

tccggagccaccggcgccaacggcgga	CRISPR spacer
accggaggcaccggcgccgacggcgcg	Protospacer
 ****** **********.****** .

25. spacer 7.1|1762933|27|NC_022663|CRT matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 5, identity: 0.815

tccggagccaccggcgccaacggcgga	CRISPR spacer
ctcggtgccaccggcggcaacggcggt	Protospacer
..*** ********** *********

26. spacer 7.1|1762933|27|NC_022663|CRT matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 5, identity: 0.815

tccggagccaccggcgccaacggcgga	CRISPR spacer
accggagccacgggcgccaccggcaca	Protospacer
 ********** ******* ****. *

27. spacer 7.1|1762933|27|NC_022663|CRT matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 5, identity: 0.815

tccggagccaccggcgccaacggcgga	CRISPR spacer
ttcggcgccaccgacgccaacggcgac	Protospacer
*.*** *******.***********.

28. spacer 7.1|1762933|27|NC_022663|CRT matches to NC_011879 (Pseudarthrobacter chlorophenolicus A6 plasmid pACHL01, complete sequence) position: , mismatch: 5, identity: 0.815

tccggagccaccggcgccaacggcgga	CRISPR spacer
accggaggcaccggcgccatcggcgag	Protospacer
 ****** *********** *****..

29. spacer 7.1|1762933|27|NC_022663|CRT matches to MG812496 (Gordonia phage SallySpecial, complete genome) position: , mismatch: 5, identity: 0.815

tccggagccaccggcgccaacggcgga	CRISPR spacer
gccggcgccaccggcgccaccggcgcc	Protospacer
 **** ************* *****

30. spacer 7.1|1762933|27|NC_022663|CRT matches to MG812496 (Gordonia phage SallySpecial, complete genome) position: , mismatch: 5, identity: 0.815

tccggagccaccggcgccaacggcgga	CRISPR spacer
accggcgccaccggcgccaagggcgac	Protospacer
 **** ************** ****.

31. spacer 7.1|1762933|27|NC_022663|CRT matches to NC_042031 (Mycobacterium phage Anaya, complete sequence) position: , mismatch: 5, identity: 0.815

tccggagccaccggcgccaacggcgga	CRISPR spacer
agcggtgccaccggcgccgacggcggt	Protospacer
  *** ************.*******

32. spacer 7.1|1762933|27|NC_022663|CRT matches to NC_007336 (Cupriavidus pinatubonensis JMP134 megaplasmid, complete sequence) position: , mismatch: 5, identity: 0.815

tccggagccaccggcgccaacggcgga	CRISPR spacer
tccggagcgaccggcgccaacgcacgc	Protospacer
******** *************   *

33. spacer 7.1|1762933|27|NC_022663|CRT matches to KX344445 (Streptomyces phage Nanodon, complete genome) position: , mismatch: 5, identity: 0.815

tccggagccaccggcgccaacggcgga	CRISPR spacer
tccggagcgaccggcgtcaacggagac	Protospacer
******** *******.****** *.

34. spacer 7.1|1762933|27|NC_022663|CRT matches to NZ_CP044425 (Paracoccus pantotrophus strain DSM 2944 plasmid pPAN2, complete sequence) position: , mismatch: 5, identity: 0.815

tccggagccaccggcgccaacggcgga	CRISPR spacer
accggcgccaccggcgccatcggccgg	Protospacer
 **** ************* **** *.

35. spacer 7.2|1762978|27|NC_022663|CRT matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 5, identity: 0.815

gccgcagggctgatcggcaacggcggg	CRISPR spacer
aacgccgggctgatcggaaacggcggc	Protospacer
. *** *********** ********

36. spacer 7.2|1762978|27|NC_022663|CRT matches to NZ_CP022191 (Yangia pacifica strain YSBP01 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.815

gccgcagggctgatcggcaacggcggg	CRISPR spacer
accgcagggctgatcggcgacgccgac	Protospacer
.*****************.*** **.

37. spacer 7.2|1762978|27|NC_022663|CRT matches to NZ_CP021026 (Rhizobium sp. TAL182 plasmid pRetTAL182b, complete sequence) position: , mismatch: 5, identity: 0.815

gccgcagggctgatcggcaacggcggg	CRISPR spacer
gccgcagggctgatcggcatcgaagat	Protospacer
******************* **. *.

38. spacer 7.2|1762978|27|NC_022663|CRT matches to NZ_CP013597 (Rhizobium sp. N741 plasmid pRspN741b, complete sequence) position: , mismatch: 5, identity: 0.815

gccgcagggctgatcggcaacggcggg	CRISPR spacer
gccgcagggctgatcggcatcgaagat	Protospacer
******************* **. *.

39. spacer 7.2|1762978|27|NC_022663|CRT matches to NZ_CP013501 (Rhizobium esperanzae strain N561 plasmid pRspN561a, complete sequence) position: , mismatch: 5, identity: 0.815

gccgcagggctgatcggcaacggcggg	CRISPR spacer
gccgcagggctgatcggcatcgaagat	Protospacer
******************* **. *.

40. spacer 7.2|1762978|27|NC_022663|CRT matches to NZ_CP013507 (Rhizobium sp. N1341 plasmid pRspN1341b, complete sequence) position: , mismatch: 5, identity: 0.815

gccgcagggctgatcggcaacggcggg	CRISPR spacer
gccgcagggctgatcggcatcgaagat	Protospacer
******************* **. *.

41. spacer 7.2|1762978|27|NC_022663|CRT matches to NZ_CP013518 (Rhizobium sp. N113 plasmid pRspN113a, complete sequence) position: , mismatch: 5, identity: 0.815

gccgcagggctgatcggcaacggcggg	CRISPR spacer
gccgcagggctgatcggcatcgaagat	Protospacer
******************* **. *.

42. spacer 7.2|1762978|27|NC_022663|CRT matches to NZ_CP013491 (Rhizobium sp. N6212 plasmid pRspN6212a, complete sequence) position: , mismatch: 5, identity: 0.815

gccgcagggctgatcggcaacggcggg	CRISPR spacer
gccgcagggctgatcggcatcgaagat	Protospacer
******************* **. *.

43. spacer 7.2|1762978|27|NC_022663|CRT matches to NZ_CP013513 (Rhizobium sp. N1314 plasmid pRspN1314b, complete sequence) position: , mismatch: 5, identity: 0.815

gccgcagggctgatcggcaacggcggg	CRISPR spacer
gccgcagggctgatcggcatcgaagat	Protospacer
******************* **. *.

44. spacer 7.2|1762978|27|NC_022663|CRT matches to NZ_CP013496 (Rhizobium sp. N621 plasmid pRspN621a, complete sequence) position: , mismatch: 5, identity: 0.815

gccgcagggctgatcggcaacggcggg	CRISPR spacer
gccgcagggctgatcggcatcgaagat	Protospacer
******************* **. *.

45. spacer 7.2|1762978|27|NC_022663|CRT matches to NZ_CP013591 (Rhizobium sp. N871 plasmid pRspN871a, complete sequence) position: , mismatch: 5, identity: 0.815

gccgcagggctgatcggcaacggcggg	CRISPR spacer
gccgcagggctgatcggcatcgaagat	Protospacer
******************* **. *.

46. spacer 7.2|1762978|27|NC_022663|CRT matches to NZ_CP013603 (Rhizobium sp. N731 plasmid pRspN731b, complete sequence) position: , mismatch: 5, identity: 0.815

gccgcagggctgatcggcaacggcggg	CRISPR spacer
gccgcagggctgatcggcatcgaagat	Protospacer
******************* **. *.

47. spacer 7.2|1762978|27|NC_022663|CRT matches to NZ_CP029357 (Azospirillum sp. CFH 70021 plasmid unnamed2) position: , mismatch: 5, identity: 0.815

gccgcagggctgatcggcaacggcggg	CRISPR spacer
gccaacctgctgatcggcaacggcggg	Protospacer
***.    *******************

48. spacer 7.1|1762933|27|NC_022663|CRT matches to AB920995 (Ralstonia phage RSJ2 DNA, complete genome) position: , mismatch: 6, identity: 0.778

tccggagccaccggcgccaacggcgga	CRISPR spacer
gagcgagccaccggccccaacggcggc	Protospacer
    *********** **********

49. spacer 7.1|1762933|27|NC_022663|CRT matches to NZ_CP039340 (Ralstonia solanacearum strain UW386 plasmid pUW386, complete sequence) position: , mismatch: 6, identity: 0.778

tccggagccaccggcgccaacggcgga	CRISPR spacer
ggcggtgccaacggcgccaacggcgcc	Protospacer
  *** **** **************

50. spacer 7.1|1762933|27|NC_022663|CRT matches to MN234174 (Mycobacterium phage Efra2, complete genome) position: , mismatch: 6, identity: 0.778

tccggagccaccggcgccaacggcgga	CRISPR spacer
agcggcgccaccggcgccgacggcgcc	Protospacer
  *** ************.******

51. spacer 7.1|1762933|27|NC_022663|CRT matches to MN234165 (Mycobacterium phage Yunkel11, complete genome) position: , mismatch: 6, identity: 0.778

tccggagccaccggcgccaacggcgga	CRISPR spacer
agcggcgccaccggcgccgacggcgcc	Protospacer
  *** ************.******

52. spacer 7.1|1762933|27|NC_022663|CRT matches to MT701598 (Streptomyces phage Sitrop, complete genome) position: , mismatch: 6, identity: 0.778

tccggagccaccggcgccaacggcgga	CRISPR spacer
accggagccaccggccccatcggcccg	Protospacer
 ************** *** ****  .

53. spacer 7.1|1762933|27|NC_022663|CRT matches to JN698995 (Mycobacterium phage Dori, complete genome) position: , mismatch: 6, identity: 0.778

tccggagccaccggcgccaacggcgga	CRISPR spacer
ggaggtgccaccggcggcaacggcggc	Protospacer
   ** ********** *********

54. spacer 7.1|1762933|27|NC_022663|CRT matches to MN234201 (Mycobacterium phage Guanica15, complete genome) position: , mismatch: 6, identity: 0.778

tccggagccaccggcgccaacggcgga	CRISPR spacer
agcggcgccaccggcgccgacggcgcc	Protospacer
  *** ************.******

55. spacer 7.1|1762933|27|NC_022663|CRT matches to MH669013 (Gordonia phage Skysand, complete genome) position: , mismatch: 6, identity: 0.778

tccggagccaccggcgccaacggcgga	CRISPR spacer
tccggccccaccggcgccaacggttcc	Protospacer
*****  ****************.

56. spacer 7.1|1762933|27|NC_022663|CRT matches to MF919542 (Gordonia phage Patio, complete genome) position: , mismatch: 6, identity: 0.778

tccggagccaccggcgccaacggcgga	CRISPR spacer
tccggccccaccggcgccaacggttcc	Protospacer
*****  ****************.

57. spacer 7.1|1762933|27|NC_022663|CRT matches to MK977699 (Gordonia Phage Lollipop1437, complete genome) position: , mismatch: 6, identity: 0.778

tccggagccaccggcgccaacggcgga	CRISPR spacer
tccggccccaccggcgccaacggttcc	Protospacer
*****  ****************.

58. spacer 7.12|1763467|30|NC_022663|CRT matches to NZ_CP011122 (Acetobacter oryzifermentans strain SLV-7 plasmid unnamed2, complete sequence) position: , mismatch: 6, identity: 0.8

cacggcgcaaccagcggtggcatgggtggg	CRISPR spacer
tgctgcgcaaccagcggcggcatcggtggc	Protospacer
..* *************.***** *****

59. spacer 7.12|1763467|30|NC_022663|CRT matches to NZ_CP023190 (Acetobacter pomorum strain SH plasmid pSH1, complete sequence) position: , mismatch: 6, identity: 0.8

cacggcgcaaccagcggtggcatgggtggg	CRISPR spacer
tgctgcgcaaccagcggcggcatcggtggc	Protospacer
..* *************.***** *****

60. spacer 7.12|1763467|30|NC_022663|CRT matches to NZ_CP042809 (Acetobacter oryzoeni strain B6 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.8

cacggcgcaaccagcggtggcatgggtggg	CRISPR spacer
tgctgcgcaaccagcggcggcatcggtggc	Protospacer
..* *************.***** *****

61. spacer 7.12|1763467|30|NC_022663|CRT matches to NZ_AP014882 (Acetobacter pasteurianus NBRC 101655 plasmid plasmid1 DNA, complete genome) position: , mismatch: 6, identity: 0.8

cacggcgcaaccagcggtggcatgggtggg	CRISPR spacer
tgctgcgcaaccagcggcggcatcggtggc	Protospacer
..* *************.***** *****

62. spacer 7.12|1763467|30|NC_022663|CRT matches to NC_021976 (Acetobacter pasteurianus 386B plasmid Apa386Bp1, complete sequence) position: , mismatch: 6, identity: 0.8

cacggcgcaaccagcggtggcatgggtggg	CRISPR spacer
tgctgcgcaaccagcggcggcatcggtggc	Protospacer
..* *************.***** *****

63. spacer 7.16|1763656|30|NC_022663|CRT matches to MT023084 (Citrobacter phage IME-JL8, complete genome) position: , mismatch: 6, identity: 0.8

ttcggcgccacgaacggcggcaaaggtggc	CRISPR spacer
gacagcgccacgatcggcggcaaaggttac	Protospacer
  *.********* ************* .*

64. spacer 9.1|3394618|26|NC_022663|CRISPRCasFinder matches to NZ_CP021405 (Celeribacter manganoxidans strain DY25 plasmid pDY25-A, complete sequence) position: , mismatch: 6, identity: 0.769

ttgccgtatcgagcgtgcggtggtgc	CRISPR spacer
acgccgtgtcgagcgtgcggtgggaa	Protospacer
 .*****.*************** .

65. spacer 13.3|4888393|34|NC_022663|PILER-CR matches to NC_042345 (Phage Salvo, complete genome) position: , mismatch: 6, identity: 0.824

-ctgcagtcggcggcgggaacgaggtcggcgcgag	CRISPR spacer
tctgc-gtcggcgtcgggaacgaagtcggcgtgcc	Protospacer
 **** ******* *********.*******.*

66. spacer 15.2|4892511|31|NC_022663|PILER-CR matches to NC_019366 (Paracoccus aestuarii plasmid pAES7, complete sequence) position: , mismatch: 6, identity: 0.806

gtggggtggcggctagtgcggatggtcgtat	CRISPR spacer
agcgggcggcggctaatgcggatggtcgtaa	Protospacer
.  ***.********.**************

67. spacer 19.1|5936365|29|NC_022663|CRISPRCasFinder matches to MN693744 (Marine virus AFVG_250M180, complete genome) position: , mismatch: 6, identity: 0.793

ctgcttcgcagtgcatcgtcgccggcgcg-	CRISPR spacer
atgcttcgcagtccatcgtcg-cgtcccac	Protospacer
 *********** ******** ** * *.

68. spacer 19.1|5936365|29|NC_022663|CRISPRCasFinder matches to NC_010625 (Paraburkholderia phymatum STM815 plasmid pBPHY01, complete sequence) position: , mismatch: 6, identity: 0.793

ctgcttcgcagtgcatcgtcgccggcgcg	CRISPR spacer
ccgagacgcacggcatcgtcgccggcgcg	Protospacer
*.*   ****  *****************

69. spacer 7.6|1763200|30|NC_022663|CRT matches to NZ_CP025613 (Niveispirillum cyanobacteriorum strain TH16 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.767

ttcacccagagcaacaccgcgctcggtggg	CRISPR spacer
ctcacccagagcgacagcgcgctcgccaag	Protospacer
.***********.*** ******** ...*

70. spacer 7.6|1763200|30|NC_022663|CRT matches to NC_010333 (Caulobacter sp. K31 plasmid pCAUL02, complete sequence) position: , mismatch: 7, identity: 0.767

ttcacccagagcaacaccgcgctcggtggg	CRISPR spacer
ctcacccagagcaacatcacgctctgcgcc	Protospacer
.***************.*.***** *.*

71. spacer 19.1|5936365|29|NC_022663|CRISPRCasFinder matches to NZ_AP014579 (Burkholderia sp. RPE67 plasmid p1, complete sequence) position: , mismatch: 7, identity: 0.759

ctgcttcgcagtgcatcgtcgccggcgcg	CRISPR spacer
cgcgcaggcggtgcatcgtcgccggcgcg	Protospacer
*   .  **.*******************

72. spacer 19.1|5936365|29|NC_022663|CRISPRCasFinder matches to NC_016626 (Burkholderia sp. YI23 plasmid byi_1p, complete sequence) position: , mismatch: 7, identity: 0.759

ctgcttcgcagtgcatcgtcgccggcgcg	CRISPR spacer
cgcgcaggcggtgcatcgtcgccggcgcg	Protospacer
*   .  **.*******************

73. spacer 19.1|5936365|29|NC_022663|CRISPRCasFinder matches to NC_013193 (Candidatus Accumulibacter phosphatis clade IIA str. UW-1 plasmid pAph01, complete sequence) position: , mismatch: 7, identity: 0.759

ctgcttcgcagtgcatcgtcgccggcgcg	CRISPR spacer
gggtgacgcagtgcatcagcgccggcgcg	Protospacer
  *.  ***********. **********

74. spacer 7.6|1763200|30|NC_022663|CRT matches to NZ_CP022191 (Yangia pacifica strain YSBP01 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.733

ttcacccagagcaacaccgcgctcggtggg	CRISPR spacer
gtcaccgagatcaacaccgcgctcttcccg	Protospacer
 ***** *** *************  .  *

75. spacer 7.6|1763200|30|NC_022663|CRT matches to NZ_CP014599 (Yangia sp. CCB-MM3 plasmid unnamed3, complete sequence) position: , mismatch: 8, identity: 0.733

ttcacccagagcaacaccgcgctcggtggg	CRISPR spacer
gtcaccgagatcaacaccgcgctctttcca	Protospacer
 ***** *** *************  *  .

76. spacer 7.6|1763200|30|NC_022663|CRT matches to NC_028827 (Streptomyces phage Lannister, complete genome) position: , mismatch: 8, identity: 0.733

ttcacccagagcaacaccgcgctcggtggg	CRISPR spacer
ccccatgagagcgacaccgcgctcgatggg	Protospacer
..*  . *****.************.****

77. spacer 7.6|1763200|30|NC_022663|CRT matches to NC_014309 (Ralstonia solanacearum CFBP2957 plasmid RCFBPv3_mp, complete genome) position: , mismatch: 8, identity: 0.733

ttcacccagagcaacaccgcgctcggtggg	CRISPR spacer
ccgcgccagcgcaacaccgcgatcggtgcg	Protospacer
..   **** *********** ****** *

78. spacer 7.6|1763200|30|NC_022663|CRT matches to NZ_CP021767 (Ralstonia solanacearum strain RS 489 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.733

ttcacccagagcaacaccgcgctcggtggg	CRISPR spacer
ccgcgccagcgcaacaccgcgatcggtgcg	Protospacer
..   **** *********** ****** *

79. spacer 7.6|1763200|30|NC_022663|CRT matches to NZ_CP021765 (Ralstonia pseudosolanacearum strain CRMRs218 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.733

ttcacccagagcaacaccgcgctcggtggg	CRISPR spacer
ccgcgccagcgcaacaccgcgatcggtgcg	Protospacer
..   **** *********** ****** *

80. spacer 7.16|1763656|30|NC_022663|CRT matches to MK448878 (Streptococcus phage Javan224, complete genome) position: , mismatch: 8, identity: 0.733

ttcggcgccacgaacggcggcaaaggtggc	CRISPR spacer
tgtatcgccacgaacggcggtaaaggtcag	Protospacer
* .. ***************.****** .

81. spacer 7.16|1763656|30|NC_022663|CRT matches to NZ_CP010612 (Phaeobacter inhibens strain P92 plasmid pP92_b, complete sequence) position: , mismatch: 8, identity: 0.733

ttcggcgccacgaacggcggcaaaggtggc	CRISPR spacer
gtaggcgccacgcacgccggcaaagggcaa	Protospacer
 * ********* *** *********  .

82. spacer 7.16|1763656|30|NC_022663|CRT matches to NZ_CP010630 (Phaeobacter inhibens strain P78 plasmid pP78_a, complete sequence) position: , mismatch: 8, identity: 0.733

ttcggcgccacgaacggcggcaaaggtggc	CRISPR spacer
gtaggcgccacgcacgccggcaaagggcaa	Protospacer
 * ********* *** *********  .

83. spacer 7.16|1763656|30|NC_022663|CRT matches to NZ_CP010600 (Phaeobacter inhibens strain P83 plasmid pP83_a, complete sequence) position: , mismatch: 8, identity: 0.733

ttcggcgccacgaacggcggcaaaggtggc	CRISPR spacer
gtaggcgccacgcacgccggcaaagggcaa	Protospacer
 * ********* *** *********  .

84. spacer 7.16|1763656|30|NC_022663|CRT matches to NZ_CP010726 (Phaeobacter inhibens strain P88 plasmid pP88_a, complete sequence) position: , mismatch: 8, identity: 0.733

ttcggcgccacgaacggcggcaaaggtggc	CRISPR spacer
gtaggcgccacgcacgccggcaaagggcaa	Protospacer
 * ********* *** *********  .

85. spacer 7.16|1763656|30|NC_022663|CRT matches to NZ_CP010706 (Phaeobacter inhibens strain P66 plasmid pP66_a, complete sequence) position: , mismatch: 8, identity: 0.733

ttcggcgccacgaacggcggcaaaggtggc	CRISPR spacer
gtaggcgccacgcacgccggcaaagggcaa	Protospacer
 * ********* *** *********  .

86. spacer 7.16|1763656|30|NC_022663|CRT matches to CP006880 (Rhizobium gallicum bv. gallicum R602 plasmid pRgalR602c, complete sequence) position: , mismatch: 8, identity: 0.733

ttcggcgccacgaacggcggcaaaggtggc	CRISPR spacer
taccgcgccaagaacggcggcaaagagcag	Protospacer
* * ****** **************.  .

87. spacer 7.16|1763656|30|NC_022663|CRT matches to NZ_CP019308 (Phaeobacter inhibens strain DOK1-1 plasmid pDOK1-1-1, complete sequence) position: , mismatch: 8, identity: 0.733

ttcggcgccacgaacggcggcaaaggtggc	CRISPR spacer
gtaggcgccacgcacgccggcaaagggcaa	Protospacer
 * ********* *** *********  .

88. spacer 7.16|1763656|30|NC_022663|CRT matches to NZ_CP010736 (Phaeobacter inhibens strain P72 plasmid pP72_a, complete sequence) position: , mismatch: 8, identity: 0.733

ttcggcgccacgaacggcggcaaaggtggc	CRISPR spacer
gtaggcgccacgcacgccggcaaagggcaa	Protospacer
 * ********* *** *********  .

89. spacer 7.16|1763656|30|NC_022663|CRT matches to NC_018853 (Streptomyce phage TG1, complete genome) position: , mismatch: 8, identity: 0.733

ttcggcgccacgaacggcggcaaaggtggc	CRISPR spacer
gtcggcaccacgaacggcggcacctgggca	Protospacer
 *****.***************   * *

90. spacer 7.16|1763656|30|NC_022663|CRT matches to JX182372 (Streptomyces virus TG1, complete genome) position: , mismatch: 8, identity: 0.733

ttcggcgccacgaacggcggcaaaggtggc	CRISPR spacer
gtcggcaccacgaacggcggcacctgggca	Protospacer
 *****.***************   * *

91. spacer 8.1|1947314|32|NC_022663|CRISPRCasFinder matches to NC_007974 (Cupriavidus metallidurans CH34 megaplasmid, complete sequence) position: , mismatch: 8, identity: 0.75

gagtgtcgcccaccgatgtggtggccctggcg	CRISPR spacer
cggcgccaaccgccgaagtggtggccctggcg	Protospacer
 .*.*.*. **.**** ***************

92. spacer 8.1|1947314|32|NC_022663|CRISPRCasFinder matches to NZ_CP046333 (Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3) position: , mismatch: 8, identity: 0.75

gagtgtcgcccaccgatgtggtggccctggcg	CRISPR spacer
cggcgccaaccgccgaagtggtggccctggcg	Protospacer
 .*.*.*. **.**** ***************

93. spacer 7.6|1763200|30|NC_022663|CRT matches to NZ_CP021355 (Rhodococcus sp. S2-17 plasmid pRB98, complete sequence) position: , mismatch: 9, identity: 0.7

ttcacccagagcaacaccgcgctcggtggg	CRISPR spacer
gtcacccagagcaagaccgcgcgatctctt	Protospacer
 ************* *******    *

94. spacer 8.1|1947314|32|NC_022663|CRISPRCasFinder matches to NZ_CP045296 (Paenibacillus cellulositrophicus strain KACC 16577 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.719

gagtgtcgcccaccgatgtggtggccctggcg	CRISPR spacer
ttctgtcgccgaccgatgcggtggccgtcggt	Protospacer
   ******* *******.******* * *

95. spacer 8.1|1947314|32|NC_022663|CRISPRCasFinder matches to NZ_CP015882 (Ensifer adhaerens strain Casida A plasmid pCasidaAB, complete sequence) position: , mismatch: 9, identity: 0.719

gagtgtcgcccaccgatgtggtggccctggcg	CRISPR spacer
gctgctatcccaccgatctggtggacctggct	Protospacer
*    *  ********* ****** ******

96. spacer 8.1|1947314|32|NC_022663|CRISPRCasFinder matches to NZ_CP030264 (Ensifer adhaerens strain Corn53 plasmid AB, complete sequence) position: , mismatch: 9, identity: 0.719

gagtgtcgcccaccgatgtggtggccctggcg	CRISPR spacer
gctgctatcccaccgatctggtggacctggct	Protospacer
*    *  ********* ****** ******

97. spacer 15.2|4892511|31|NC_022663|PILER-CR matches to NZ_LR594669 (Variovorax sp. SRS16 plasmid 4) position: , mismatch: 9, identity: 0.71

gtggggtggcggctagtgcggatggtcgtat	CRISPR spacer
cttcatcggcggatagtgcggatggccgtag	Protospacer
 *  . .***** ************.****

98. spacer 15.2|4892511|31|NC_022663|PILER-CR matches to NZ_LR594673 (Variovorax sp. PBL-E5 plasmid 3) position: , mismatch: 9, identity: 0.71

gtggggtggcggctagtgcggatggtcgtat	CRISPR spacer
cttcatcggcgggtagtgcggatggccgtag	Protospacer
 *  . .***** ************.****

99. spacer 5.3|1068161|37|NC_022663|CRISPRCasFinder matches to KJ025957 (Serratia phage PS2, complete genome) position: , mismatch: 10, identity: 0.73

ggtgttgccgatatttccaccacccagattggtgcta	CRISPR spacer
aatgttgccgatatttccatcacctagaacaatgaca	Protospacer
..*****************.****.*** ...** .*

100. spacer 5.5|1068266|37|NC_022663|CRISPRCasFinder matches to NZ_CP014361 (Methylomonas sp. DH-1 plasmid, complete sequence) position: , mismatch: 10, identity: 0.73

gccgctgcccaggttgatgtcgccccggtttccgcca	CRISPR spacer
atcctggatcaggttgatgtcgcccaggttgccgccg	Protospacer
..* . * .**************** **** *****.

101. spacer 7.12|1763467|30|NC_022663|CRT matches to NZ_CP017887 (Pseudomonas frederiksbergensis strain ERDD5:01 plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.667

cacggcgcaaccagcggtggcatgggtggg	CRISPR spacer
gtcggcgcaacgagcggtggcatccagcaa	Protospacer
  ********* ***********  .  ..

102. spacer 8.1|1947314|32|NC_022663|CRISPRCasFinder matches to NZ_CP022367 (Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence) position: , mismatch: 10, identity: 0.688

gagtgtcgcccaccgatgtggtggccctggcg	CRISPR spacer
atccacagcccaccgatgtggtcgcgctggtg	Protospacer
.  ... *************** ** ****.*

103. spacer 13.3|4888393|34|NC_022663|PILER-CR matches to NZ_CP019438 (Thioclava nitratireducens strain 25B10_4 plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.706

ctgcagtcggcggcgggaacgaggtcggcgcgag	CRISPR spacer
aagccgtccgcggcgggaacgaggtcgaacccga	Protospacer
  ** *** ******************.  * ..

104. spacer 13.3|4888393|34|NC_022663|PILER-CR matches to NZ_CP032340 (Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence) position: , mismatch: 10, identity: 0.706

ctgcagtcggcggcgggaacgaggtcggcgcgag	CRISPR spacer
ccccgtccggcggtgggaacgaggtcggtgccga	Protospacer
*. *. .******.**************.** ..

105. spacer 13.3|4888393|34|NC_022663|PILER-CR matches to NZ_CP012915 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence) position: , mismatch: 10, identity: 0.706

ctgcagtcggcggcgggaacgaggtcggcgcgag	CRISPR spacer
ccccgtccggcggtgggaacgaggtcggtgccga	Protospacer
*. *. .******.**************.** ..

106. spacer 13.3|4888393|34|NC_022663|PILER-CR matches to NC_047910 (Faecalibacterium phage FP_Epona, complete genome) position: , mismatch: 10, identity: 0.706

ctgcagtcggcggcgggaacgaggtcggcgcgag	CRISPR spacer
gggttgtaggcggcgggaatgaggtcggccagtc	Protospacer
  *. ** ***********.*********  *

107. spacer 15.1|4892433|37|NC_022663|PILER-CR matches to NZ_LR594664 (Variovorax sp. RA8 plasmid 3) position: , mismatch: 10, identity: 0.73

tgattgatgcggcgagtgcgatcgcggtgggggagac	CRISPR spacer
tgagtggtgcggcgagtgcgatcgcgcagcgcagttc	Protospacer
*** **.*******************  * * ..  *

108. spacer 5.5|1068266|37|NC_022663|CRISPRCasFinder matches to NZ_CP014361 (Methylomonas sp. DH-1 plasmid, complete sequence) position: , mismatch: 11, identity: 0.703

gccgctgcccaggttgatgtcgccccggtttccgcca	CRISPR spacer
atcctggatcaggttgatgtcgcccaggttgccgctg	Protospacer
..* . * .**************** **** ****..

109. spacer 8.1|1947314|32|NC_022663|CRISPRCasFinder matches to NZ_CP032322 (Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence) position: , mismatch: 11, identity: 0.656

gagtgtcgcccaccgatgtggtggccctggcg	CRISPR spacer
atccccagcccaccgacgtggtggcgctggtc	Protospacer
.  . . *********.******** ****.

110. spacer 8.1|1947314|32|NC_022663|CRISPRCasFinder matches to NZ_CP007794 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence) position: , mismatch: 11, identity: 0.656

gagtgtcgcccaccgatgtggtggccctggcg	CRISPR spacer
atcctcagcccaccgacgtggtggcgctggtc	Protospacer
.  . . *********.******** ****.

111. spacer 8.1|1947314|32|NC_022663|CRISPRCasFinder matches to NZ_CP032340 (Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence) position: , mismatch: 11, identity: 0.656

gagtgtcgcccaccgatgtggtggccctggcg	CRISPR spacer
acccccagcccaccgacgtggtggcgctggtc	Protospacer
.  . . *********.******** ****.

112. spacer 8.1|1947314|32|NC_022663|CRISPRCasFinder matches to NZ_CP032346 (Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence) position: , mismatch: 11, identity: 0.656

gagtgtcgcccaccgatgtggtggccctggcg	CRISPR spacer
acccccagcccaccgacgtggtggcgctggtc	Protospacer
.  . . *********.******** ****.

113. spacer 8.1|1947314|32|NC_022663|CRISPRCasFinder matches to NZ_CP012915 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence) position: , mismatch: 11, identity: 0.656

gagtgtcgcccaccgatgtggtggccctggcg	CRISPR spacer
acccccagcccaccgacgtggtggcgctggtc	Protospacer
.  . . *********.******** ****.

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

426473 : 449374

Leptospira_phage(75.0%)

transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_036391246.1\|426473_428198_-\|transposase	IS1634 family transposase	NA	NA	NA	NA
WP_023364629.1\|428365_428758_-	hypothetical protein	NA	NA	NA	NA
WP_103802187.1\|429440_430702_-\|transposase	IS3 family transposase	Q8W6R2	Burkholderia_virus	1.2e-72	55.4
WP_080673978.1\|430818_431352_+	hypothetical protein	NA	NA	NA	NA
WP_080674186.1\|431539_432079_+	hypothetical protein	NA	NA	NA	NA
WP_129111949.1\|432261_433378_+\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	1.6e-33	34.9
WP_080673980.1\|434072_434600_-	hypothetical protein	NA	NA	NA	NA
WP_023364638.1\|434928_437259_+	hypothetical protein	NA	NA	NA	NA
WP_036395997.1\|437465_438095_+	hypothetical protein	NA	NA	NA	NA
WP_122443431.1\|438444_439562_-\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	6.2e-33	34.5
WP_023364643.1\|440027_441092_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_023364648.1\|443552_443867_-	hypothetical protein	NA	NA	NA	NA
WP_129111946.1\|443921_444485_-	hypothetical protein	NA	NA	NA	NA
WP_023364650.1\|444979_445519_-	hypothetical protein	NA	NA	NA	NA
WP_129111949.1\|448257_449374_+\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	1.6e-33	34.9

DBSCAN-SWA_2

516157 : 595019

Erysipelothrix_phage(12.5%)

integrase,tRNA,transposase

attL 592731:592790|attR 596097:596187

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_023364695.1\|516157_517000_-\|tRNA	tRNA (adenine(58)-N(1))-methyltransferase TrmI	NA	NA	NA	NA
WP_023364696.1\|517073_517943_+	RecB family exonuclease	NA	NA	NA	NA
WP_023364697.1\|517939_518743_+	thioesterase family protein	NA	NA	NA	NA
WP_023364698.1\|519106_520486_-	FAD-containing oxidoreductase	A0A2K5B2C5	Erysipelothrix_phage	1.5e-60	33.3
WP_036395983.1\|520482_520968_-	membrane protein	NA	NA	NA	NA
WP_036393190.1\|521093_521948_-	ATP phosphoribosyltransferase	NA	NA	NA	NA
WP_023364701.1\|521950_522232_-	phosphoribosyl-ATP diphosphatase	NA	NA	NA	NA
WP_036393187.1\|522403_523246_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_036393185.1\|523540_525028_+	arylsulfatase	A0A2P0VMN7	Tetraselmis_virus	5.1e-107	42.8
WP_023364704.1\|525047_527402_+	sulfatase-like hydrolase/transferase	NA	NA	NA	NA
WP_042313221.1\|527500_528748_-	PPE family protein	NA	NA	NA	NA
WP_023364706.1\|529065_532644_-	methionine synthase	NA	NA	NA	NA
WP_042313224.1\|532763_533618_+	PAC2 family protein	NA	NA	NA	NA
WP_080674189.1\|533614_534793_-	FAD-dependent monooxygenase	NA	NA	NA	NA
WP_023364709.1\|534821_535715_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_023364710.1\|535739_536984_-	cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase	A0A1V0SAQ2	Catovirus	1.5e-27	25.4
WP_023364711.1\|537405_538194_-	3'(2'),5'-bisphosphate nucleotidase CysQ	NA	NA	NA	NA
WP_023364712.1\|538698_539514_-	SCO1664 family protein	NA	NA	NA	NA
WP_023364713.1\|539497_540085_-	DUF3090 domain-containing protein	NA	NA	NA	NA
WP_023364714.1\|540147_540876_-	MSMEG_4193 family putative phosphomutase	NA	NA	NA	NA
WP_023364715.1\|540872_541703_-	undecaprenyl-diphosphate phosphatase	NA	NA	NA	NA
WP_023364716.1\|541764_542067_-	hypothetical protein	NA	NA	NA	NA
WP_099184126.1\|542243_543239_+	hypothetical protein	NA	NA	NA	NA
WP_042311690.1\|543292_543499_+	dihydroorotate dehydrogenase	NA	NA	NA	NA
WP_051404563.1\|543525_544608_+	quinone-dependent dihydroorotate dehydrogenase	NA	NA	NA	NA
WP_023364720.1\|544674_550506_-	PE family protein	NA	NA	NA	NA
WP_023364721.1\|551098_553054_-	PE family protein	NA	NA	NA	NA
WP_023364722.1\|553493_563648_+	PPE family protein	NA	NA	NA	NA
WP_023364723.1\|563826_565077_+	ATP-binding protein	NA	NA	NA	NA
WP_023364724.1\|565171_565819_-	response regulator transcription factor	NA	NA	NA	NA
WP_023364725.1\|566131_566536_+	hypothetical protein	NA	NA	NA	NA
WP_023364726.1\|566505_567147_-	alpha/beta fold hydrolase	NA	NA	NA	NA
WP_023364727.1\|567193_567724_-	YbhB/YbcL family Raf kinase inhibitor-like protein	NA	NA	NA	NA
WP_036393176.1\|567758_569111_-	M20/M25/M40 family metallo-hydrolase	NA	NA	NA	NA
WP_023364729.1\|569306_570953_-	recombinase family protein	NA	NA	NA	NA
WP_023364731.1\|572632_574075_-	cell division protein FtsK	NA	NA	NA	NA
WP_023364732.1\|574163_574499_-	hypothetical protein	NA	NA	NA	NA
WP_023364734.1\|575864_576605_+	creatininase family protein	NA	NA	NA	NA
WP_103797949.1\|577241_578696_-	HAMP domain-containing histidine kinase	NA	NA	NA	NA
WP_036393174.1\|578632_579337_-	response regulator transcription factor	NA	NA	NA	NA
WP_023364740.1\|579944_581888_-\|integrase	tyrosine-type recombinase/integrase	A0A1B1P7C7	Bacillus_phage	4.3e-05	24.4
WP_023364742.1\|581884_582925_-\|integrase	tyrosine-type recombinase/integrase	A0A166YH27	Gordonia_phage	4.9e-08	26.3
WP_023364744.1\|582990_584052_-\|transposase	IS256 family transposase	A0A220NQR7	Corynebacterium_phage	5.3e-66	43.8
WP_023364746.1\|584282_585662_+	FAD-dependent monooxygenase	NA	NA	NA	NA
WP_080673988.1\|585969_586806_-	isoprenylcysteine carboxylmethyltransferase family protein	NA	NA	NA	NA
WP_023364748.1\|587306_588026_+	hypothetical protein	NA	NA	NA	NA
WP_080673989.1\|588289_589726_-	cytochrome P450	A0A2I2L481	Orpheovirus	8.5e-27	22.4
WP_080673990.1\|590102_591650_+	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_023364754.1\|592173_592815_+\|transposase	IS3 family transposase	U5P429	Shigella_phage	1.1e-13	31.3
592731:592790	attL	NA	NA	NA	NA
WP_023364757.1\|592872_594072_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_023364759.1\|594068_595019_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
596097:596187	attR	NA	NA	NA	NA

DBSCAN-SWA_3

2375535 : 2406261

Bacillus_phage(30.0%)

integrase,tRNA,transposase

attL 2394898:2394957|attR 2406526:2406849

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_023367953.1\|2375535_2376726_+\|tRNA	tRNA dihydrouridine synthase DusB	NA	NA	NA	NA
WP_036394034.1\|2376878_2379044_+	LCP family protein	NA	NA	NA	NA
WP_023367957.1\|2379088_2379757_+	phosphate signaling complex protein PhoU	NA	NA	NA	NA
WP_023367959.1\|2379767_2380544_-	phosphate ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.1e-17	34.6
WP_023367961.1\|2380557_2381472_-	phosphate ABC transporter permease PstA	NA	NA	NA	NA
WP_036393793.1\|2381468_2382494_-	phosphate ABC transporter permease subunit PstC	NA	NA	NA	NA
WP_023367965.1\|2382567_2383692_-	phosphate ABC transporter substrate-binding protein PstS	A0A2R8FEI2	Cedratvirus	5.5e-05	41.5
WP_023367967.1\|2383810_2384752_-	mycothiol synthase	NA	NA	NA	NA
WP_023367969.1\|2384748_2385513_-	response regulator transcription factor	W8CYM9	Bacillus_phage	8.9e-15	34.6
WP_036393795.1\|2385619_2385859_+	hypothetical protein	NA	NA	NA	NA
WP_023367973.1\|2386685_2387486_+	mannan chain length control protein LmeA	NA	NA	NA	NA
WP_036393799.1\|2387778_2388246_+	DUF4395 domain-containing protein	NA	NA	NA	NA
WP_023367977.1\|2388284_2389127_+	sulfurtransferase	NA	NA	NA	NA
WP_023367979.1\|2389128_2389431_+	DUF1416 domain-containing protein	NA	NA	NA	NA
WP_099184325.1\|2389560_2390235_+	FABP family protein	NA	NA	NA	NA
WP_042312135.1\|2390357_2392760_+	hypothetical protein	NA	NA	NA	NA
WP_023367989.1\|2392869_2394381_+	sensor domain-containing protein	NA	NA	NA	NA
2394898:2394957	attL	NA	NA	NA	NA
WP_023364740.1\|2395221_2397165_-\|integrase	tyrosine-type recombinase/integrase	A0A1B1P7C7	Bacillus_phage	4.3e-05	24.4
WP_023364742.1\|2397161_2398202_-\|integrase	tyrosine-type recombinase/integrase	A0A166YH27	Gordonia_phage	4.9e-08	26.3
WP_023364744.1\|2398267_2399329_-\|transposase	IS256 family transposase	A0A220NQR7	Corynebacterium_phage	5.3e-66	43.8
WP_082273697.1\|2399419_2400148_-	hypothetical protein	NA	NA	NA	NA
WP_023367994.1\|2400402_2400639_+	hypothetical protein	NA	NA	NA	NA
WP_122443431.1\|2400826_2401943_+\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	6.2e-33	34.5
WP_023364744.1\|2402153_2403215_+\|transposase	IS256 family transposase	A0A220NQR7	Corynebacterium_phage	5.3e-66	43.8
WP_023364742.1\|2403280_2404321_+\|integrase	tyrosine-type recombinase/integrase	A0A166YH27	Gordonia_phage	4.9e-08	26.3
WP_023364740.1\|2404317_2406261_+\|integrase	tyrosine-type recombinase/integrase	A0A1B1P7C7	Bacillus_phage	4.3e-05	24.4
2406526:2406849	attR	NA	NA	NA	NA

DBSCAN-SWA_4

3727682 : 3767049

Pandoravirus(50.0%)

protease,integrase,transposase

attL 3758746:3758786|attR 3769056:3769096

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_036396138.1\|3727682_3729071_+\|protease	type VII secretion-associated serine protease mycosin	NA	NA	NA	NA
WP_023369894.1\|3729067_3730066_+	type VII secretion protein EccE	NA	NA	NA	NA
WP_036396152.1\|3730052_3731264_-	alpha/beta fold hydrolase	NA	NA	NA	NA
WP_023369898.1\|3731417_3732200_+	trans-aconitate 2-methyltransferase	NA	NA	NA	NA
WP_099185019.1\|3732625_3734029_-	sulfatase	NA	NA	NA	NA
WP_023369902.1\|3734095_3734746_-	5,6-dimethylbenzimidazole synthase	NA	NA	NA	NA
WP_023369904.1\|3734801_3735284_-	hypothetical protein	NA	NA	NA	NA
WP_036396154.1\|3735341_3736010_+	phosphatase PAP2 family protein	NA	NA	NA	NA
WP_023369908.1\|3736112_3736769_+	L,D-transpeptidase	NA	NA	NA	NA
WP_023369910.1\|3736778_3737291_-	nuclear transport factor 2 family protein	NA	NA	NA	NA
WP_023369912.1\|3737334_3738564_+	hypothetical protein	NA	NA	NA	NA
WP_023369914.1\|3738717_3740613_+	Hsp70 family protein	NA	NA	NA	NA
WP_036396157.1\|3740839_3742249_+	hypothetical protein	NA	NA	NA	NA
WP_023369918.1\|3742316_3742703_+	hypothetical protein	NA	NA	NA	NA
WP_023369920.1\|3742707_3743442_-	DUF3060 domain-containing protein	NA	NA	NA	NA
WP_023369922.1\|3743498_3744518_+	NADP-dependent oxidoreductase	NA	NA	NA	NA
WP_036396141.1\|3744645_3745527_+	family 16 glycosylhydrolase	NA	NA	NA	NA
WP_023369926.1\|3745587_3746202_+	muconolactone Delta-isomerase family protein	NA	NA	NA	NA
WP_023369928.1\|3746222_3747719_+	bifunctional phosphatase PAP2/diacylglycerol kinase family protein	NA	NA	NA	NA
WP_023369930.1\|3747755_3749648_+	serine/threonine protein kinase	A0A0B5J6A8	Pandoravirus	5.8e-15	27.1
WP_133163603.1\|3750816_3751386_-	lipoprotein LpqH	NA	NA	NA	NA
WP_023369935.1\|3751538_3751880_-	hypothetical protein	NA	NA	NA	NA
WP_023369937.1\|3753297_3754629_-	adenylate/guanylate cyclase domain-containing protein	NA	NA	NA	NA
WP_023369939.1\|3754715_3755816_-	ferritin-like domain-containing protein	NA	NA	NA	NA
WP_023369941.1\|3755970_3757725_-	YncE family protein	NA	NA	NA	NA
3758746:3758786	attL	NA	NA	NA	NA
WP_122530125.1\|3759276_3760393_+\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	2.2e-30	33.7
WP_023369948.1\|3760522_3760828_-	hypothetical protein	NA	NA	NA	NA
WP_023369952.1\|3761442_3762927_-	hypothetical protein	NA	NA	NA	NA
WP_036396191.1\|3762908_3763223_-	DUF2563 family protein	NA	NA	NA	NA
WP_142396053.1\|3763439_3763649_-\|transposase	transposase	NA	NA	NA	NA
WP_023369958.1\|3763862_3764903_-\|integrase	site-specific integrase	NA	NA	NA	NA
WP_023369960.1\|3764902_3765853_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_023369962.1\|3765849_3767049_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
3769056:3769096	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NC_022654

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

60231 : 114260

Mycobacterium_phage(45.45%)

integrase,protease,transposase

attL 55646:55661|attR 121221:121236

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
55646:55661	attL	NA	NA	NA	NA
WP_040624331.1\|60231_61932_-\|protease	type VII secretion-associated serine protease mycosin	V5UPA7	Mycobacterium_phage	5.6e-70	35.2
WP_080674295.1\|61948_63592_-	type VII secretion integral membrane protein EccD	NA	NA	NA	NA
WP_007172339.1\|65052_65973_-	ESX secretion-associated protein EspG	NA	NA	NA	NA
WP_007172340.1\|66051_66336_-	WXG100 family type VII secretion target	NA	NA	NA	NA
WP_007172341.1\|66380_66677_-	WXG100 family type VII secretion target	NA	NA	NA	NA
WP_007172342.1\|66820_67975_-	PPE family protein	NA	NA	NA	NA
WP_007172343.1\|68004_68301_-	PE family protein	NA	NA	NA	NA
WP_007172344.1\|68394_72621_-	type VII secretion protein EccC	A0A0A0RUH6	Bacillus_phage	2.8e-17	31.7
WP_101930849.1\|72617_74063_-	type VII secretion protein EccB	V5UN45	Mycobacterium_phage	1.3e-59	34.7
WP_023363502.1\|74176_75217_-	C40 family peptidase	V5UPI8	Mycobacterium_phage	1.1e-15	41.7
WP_051404593.1\|75302_76406_-	hypothetical protein	A0A1B3B1U7	Gordonia_phage	3.0e-32	59.5
WP_023363505.1\|76469_77444_-	hypothetical protein	NA	NA	NA	NA
WP_007172349.1\|77545_77809_+	type II toxin-antitoxin system VapB family antitoxin	NA	NA	NA	NA
WP_040624374.1\|77811_78228_+	type II toxin-antitoxin system VapC family toxin	NA	NA	NA	NA
WP_169733147.1\|78509_79772_-\|transposase	IS256 family transposase	NA	NA	NA	NA
WP_007172352.1\|79983_80565_+\|transposase	IS607 family transposase	F9VHY9	Thermus_phage	1.4e-23	33.0
WP_040624340.1\|80564_82217_+\|transposase	transposase	A0A7P9	Microcystis_virus	8.0e-21	26.6
WP_023363510.1\|82537_83260_-	hypothetical protein	NA	NA	NA	NA
WP_074021534.1\|83256_84159_-	hypothetical protein	NA	NA	NA	NA
WP_141224646.1\|84292_84700_+	hypothetical protein	NA	NA	NA	NA
WP_155254717.1\|85590_86022_-	hypothetical protein	NA	NA	NA	NA
WP_139315440.1\|86252_86525_-	hypothetical protein	NA	NA	NA	NA
WP_139315441.1\|86648_87320_-	hypothetical protein	NA	NA	NA	NA
WP_007172361.1\|87429_88509_-	hypothetical protein	NA	NA	NA	NA
WP_155254718.1\|88623_89328_-	hypothetical protein	NA	NA	NA	NA
WP_139315443.1\|89335_90043_-	hypothetical protein	NA	NA	NA	NA
WP_007172365.1\|90260_90554_-	type II toxin-antitoxin system RelE/ParE family toxin	NA	NA	NA	NA
WP_040624378.1\|90550_90802_-	type II toxin-antitoxin system ParD family antitoxin	NA	NA	NA	NA
WP_007172367.1\|90907_91414_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_007172368.1\|91720_92158_+	WhiB family transcriptional regulator	NA	NA	NA	NA
WP_023363514.1\|92213_92804_+	hypothetical protein	NA	NA	NA	NA
WP_007172369.1\|92766_93051_+	hypothetical protein	NA	NA	NA	NA
WP_023363516.1\|93427_95290_+	helicase associated domain-containing protein	NA	NA	NA	NA
WP_007172373.1\|95450_95867_+	hypothetical protein	NA	NA	NA	NA
WP_007172374.1\|96252_97440_+	hypothetical protein	NA	NA	NA	NA
WP_007172375.1\|97552_97894_-	hypothetical protein	NA	NA	NA	NA
WP_023363520.1\|97890_99597_-	PPE domain-containing protein	NA	NA	NA	NA
WP_007172377.1\|99613_99919_-	hypothetical protein	NA	NA	NA	NA
WP_041321561.1\|99994_100309_-	hypothetical protein	NA	NA	NA	NA
WP_007172379.1\|100336_101857_-	DUF4226 domain-containing protein	V5UPX1	Mycobacterium_phage	6.5e-09	41.6
WP_074021258.1\|102078_102834_-	DUF2637 domain-containing protein	NA	NA	NA	NA
WP_007172400.1\|103662_104358_+	ParA family protein	NA	NA	NA	NA
WP_023363524.1\|104360_105122_+	hypothetical protein	NA	NA	NA	NA
WP_007172404.1\|105203_105488_+	type II toxin-antitoxin system Phd/YefM family antitoxin	NA	NA	NA	NA
WP_007172405.1\|105484_105742_+	Txe/YoeB family addiction module toxin	NA	NA	NA	NA
WP_007172406.1\|105956_106250_-	hypothetical protein	NA	NA	NA	NA
WP_101930848.1\|106266_107265_-	hypothetical protein	NA	NA	NA	NA
WP_007172408.1\|107976_108546_+	hypothetical protein	NA	NA	NA	NA
WP_007172409.1\|108535_109636_+\|integrase	tyrosine-type recombinase/integrase	A0A1B1IQT7	uncultured_Mediterranean_phage	1.1e-05	24.5
WP_007172410.1\|109754_109967_+	hypothetical protein	NA	NA	NA	NA
WP_007172412.1\|110543_112190_+	ParB N-terminal domain-containing protein	A0A2P1N496	Mycobacterium_phage	2.6e-104	44.5
WP_051404594.1\|113135_114260_+\|integrase	tyrosine-type recombinase/integrase	A0A220NQQ9	Corynebacterium_phage	5.5e-05	25.0
121221:121236	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_022663

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CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NC_022654

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection