CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_022126	Staphylococcus aureus subsp. aureus 55/2053 plasmid unnamed, complete sequence	0 crisprs	csa3	0	0	1	0
NC_022113	Staphylococcus aureus subsp. aureus 55/2053, complete sequence	13 crisprs	cas3,DEDDh,DinG,csa3,WYL	5	1	10	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

10024 : 17372

Staphylococcus_phage(50.0%)

transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001105968.1\|10024_10699_+\|transposase	IS6-like element IS257 family transposase	A0A0N9RU54	Staphylococcus_phage	9.9e-127	98.7
WP_000003267.1\|10933_13117_-	cadmium-translocating P-type ATPase CadA	E4ZFI9	Streptococcus_phage	1.3e-252	63.2
WP_000726007.1\|13109_13478_-	Cd(II)/Pb(II)/Zn(II)-sensing metalloregulatory transcriptional repressor CadC	E4ZFI8	Streptococcus_phage	4.2e-55	85.2
WP_000690630.1\|13847_14426_+	recombinase family protein	A0A0A7NPV4	Enterobacteria_phage	4.2e-41	51.7
WP_000583535.1\|14556_15165_+	recombinase family protein	G8I4U3	Mycobacterium_phage	6.6e-13	29.7
WP_000358995.1\|15355_15751_-	thioredoxin-dependent arsenate reductase	A0A2H4PQT9	Staphylococcus_phage	8.5e-62	86.3
WP_162887382.1\|15768_17061_-	arsenite efflux transporter membrane subunit ArsB	A0A2H4PQU3	Staphylococcus_phage	7.8e-189	81.9
WP_000120606.1\|17057_17372_-	As(III)-sensing metalloregulatory transcriptional repressor ArsR	A0A2H4PQT4	Staphylococcus_phage	1.6e-39	74.0

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NC_022113

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CRISPR-Cas detection and classification

Crispr_ID: NC_022113_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022113_1

564019-564111

Orphan

Consensus_repeat	Method
CTAAAGGTGAAGAGGAACGCAGTTGGATGCTA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022113_1

>merge|NC_022113|1|564019-564111|CRISPRCasFinder
CTAAAGGTGAAGAGGAACGCAGTTGGATGCTACCGCACAACTGCATAAATCCCTCTAATCGCTAAAGGTGAAGAGGAACCCAGTTGGATGCTA

>NC_022113|1|1|564019-564111|CRISPRCasFinder
CTAAAGGTGAAGAGGAACGCAGTTGGATGCTA	CCGCACAACTGCATAAATCCCTCTAATCG
CTAAAGGTGAAGAGGAACCCAGTTGGATGCTA

Protein	Signature genes	Signature genes Name	Protein_function
NC_022113.1\|WP_000735554.1\|567930_568437_+\|hypothetical-protein	unknown	unknown	unknown
NC_022113.1\|WP_001018677.1\|570521_570896_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|130944
NC_022113.1\|WP_000365352.1\|566291_567011_+\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|223943
NC_022113.1\|WP_001200748.1\|559538_560549_+\|alcohol-dehydrogenase-AdhP	unknown	unknown	gnl\|CDD\|181842
NC_022113.1\|WP_000808894.1\|554826_555765_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381309
NC_022113.1\|WP_000362975.1\|566994_567795_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NC_022113.1\|WP_001574632.1\|571843_572773_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|225778
NC_022113.1\|WP_000749051.1\|564249_565137_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238563
NC_022113.1\|WP_000477504.1\|556679_557156_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NC_022113.1\|WP_000901760.1\|563234_563870_+\|endonuclease-III-domain-containing-protein	unknown	unknown	gnl\|CDD\|225140
NC_022113.1\|WP_001045416.1\|569483_570272_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NC_022113.1\|WP_000359082.1\|560824_561241_+\|DUF1934-domain-containing-protein	unknown	unknown	gnl\|CDD\|226896
NC_022113.1\|WP_001788287.1\|558518_559040_+\|YwhD-family-protein	unknown	unknown	gnl\|CDD\|378039
NC_022113.1\|WP_000180233.1\|557195_558491_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|224004
NC_022113.1\|WP_000169038.1\|572965_573190_-\|DUF2922-domain-containing-protein	unknown	unknown	gnl\|CDD\|378571
NC_022113.1\|WP_001222137.1\|568598_569315_+\|hypothetical-protein	unknown	unknown	unknown
NC_022113.1\|WP_000882189.1\|553744_554374_+\|DUF443-family-protein	unknown	unknown	gnl\|CDD\|335700
NC_022113.1\|WP_001021140.1\|561237_562899_+\|arginine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234964
NC_022113.1\|WP_000633782.1\|555974_556511_+\|flavodoxin-family-protein	unknown	unknown	gnl\|CDD\|223728
NC_022113.1\|WP_001820041.1\|565286_566237_+\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376439

Protein	Function_ID	Function_description	E-value
NC_022113.1\|WP_001018677.1\|570521_570896_-\|transcriptional-regulator	gnl\|CDD\|130944	TIGR01889, Pleiotropic_Regulator_Of_Virulence, staphylococcal accessory regulator family. This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions].	1.77309e-26
NC_022113.1\|WP_000365352.1\|566291_567011_+\|HAD-family-hydrolase	gnl\|CDD\|223943	COG1011, COG1011, Predicted hydrolase (HAD superfamily) [General function prediction only].	5.71997e-38
NC_022113.1\|WP_001200748.1\|559538_560549_+\|alcohol-dehydrogenase-AdhP	gnl\|CDD\|181842	PRK09422, PRK09422, ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional.	0
NC_022113.1\|WP_000808894.1\|554826_555765_+\|aldo/keto-reductase	gnl\|CDD\|381309	cd19083, AKR_AKR11A1_11D1, AKR11A and AKR11D families of aldo-keto reductase (AKR). Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).	1.14602e-168
NC_022113.1\|WP_000362975.1\|566994_567795_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	5.88188e-26
NC_022113.1\|WP_001574632.1\|571843_572773_-\|DMT-family-transporter	gnl\|CDD\|225778	COG3238, COG3238, Uncharacterized protein conserved in bacteria [Function unknown].	9.03596e-35
NC_022113.1\|WP_000749051.1\|564249_565137_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|238563	cd01143, YvrC, Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind the metal ion in the cleft between these domains.	3.39555e-73
NC_022113.1\|WP_000477504.1\|556679_557156_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.13315e-11
NC_022113.1\|WP_000901760.1\|563234_563870_+\|endonuclease-III-domain-containing-protein	gnl\|CDD\|225140	COG2231, COG2231, Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair].	2.8784e-92
NC_022113.1\|WP_001045416.1\|569483_570272_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	6.25578e-35
NC_022113.1\|WP_000359082.1\|560824_561241_+\|DUF1934-domain-containing-protein	gnl\|CDD\|226896	COG4506, COG4506, Uncharacterized protein conserved in bacteria [Function unknown].	6.53088e-59
NC_022113.1\|WP_001788287.1\|558518_559040_+\|YwhD-family-protein	gnl\|CDD\|378039	pfam08741, YwhD, YwhD family. This family of proteins are currently uncharacterized. They are around 170 amino acids in length.	8.7406e-98
NC_022113.1\|WP_000180233.1\|557195_558491_+\|HD-domain-containing-protein	gnl\|CDD\|224004	COG1078, COG1078, HD superfamily phosphohydrolases [General function prediction only].	3.99954e-151
NC_022113.1\|WP_000169038.1\|572965_573190_-\|DUF2922-domain-containing-protein	gnl\|CDD\|378571	pfam11148, DUF2922, Protein of unknown function (DUF2922). This bacterial family of proteins has no known function.	3.83351e-14
NC_022113.1\|WP_000882189.1\|553744_554374_+\|DUF443-family-protein	gnl\|CDD\|335700	pfam04276, DUF443, Protein of unknown function (DUF443). Family of uncharacterized proteins.	2.66874e-44
NC_022113.1\|WP_001021140.1\|561237_562899_+\|arginine--tRNA-ligase	gnl\|CDD\|234964	PRK01611, argS, arginyl-tRNA synthetase; Reviewed.	0
NC_022113.1\|WP_000633782.1\|555974_556511_+\|flavodoxin-family-protein	gnl\|CDD\|223728	COG0655, WrbA, Multimeric flavodoxin WrbA [General function prediction only].	3.16348e-26
NC_022113.1\|WP_001820041.1\|565286_566237_+\|iron-ABC-transporter-permease	gnl\|CDD\|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	2.07219e-47

>NC_022113.1|WP_000901760.1|563234_563870_+|endonuclease-III-domain-containing-protein
MLGTDELYKLLYRHMGPQNWWPADNDIEMMLGAILVQNTRWRNAEIALNQIKEHTHFNPNHILELPIETLQSLIRPSGFYKSKSLTIKTLLTWLARHHFNYQEINERYKGELRKELLSLKGIGSETADVLLVYIFGRIEFIPDSYTRKIYNKLGYENTKSYDQLKKVVTLPNHFTNQDANEFHALLDVFGKHYFRDKDIKNCDFLEPYFKK
>NC_022113.1|WP_001021140.1|561237_562899_+|arginine--tRNA-ligase
MNIIDQVKQTLVEEIAASINKAGLADEIPDIKIEVPKDTKNGDYATNIAMVLTKIAKRNPREIAQAIVDNLDTEKAHVKQIDIAGPGFINFYLDNQYLTAIIPEAIEKGDQFGHVNESKGQNVLLEYVSANPTGDLHIGHARNAAVGDALANILTAAGYNVTREYYINDAGNQITNLARSIETRFFEALGDNSYSMPEDGYNGKDIIEIGKDLAEKHPEIKDYSEEARLKEFRKLGVEYEMAKLKNDLAEFNTHFDNWFSETSLYEKGEILEVLAKMKELGYTYEADGATWLRTTDFKDDKDRVLIKNDGTYTYFLPDIAYHFDKVKRGNDILIDLFGADHHGYINRLKASLETFGVDSNRLEIQIMQMVRLMENGKEVKMSKRTGNAITLREIMDEVGVDAARYFLTMRSPDSHFDFDMELAKEQSQDNPVYYAQYAHARICSILKQAKEQGIEVAAANDFTTITNEKAIELLKKVADFEPTIESAAEHRSAHRITNYIQDLASHFHKFYNAEKVLTDDIEKTKAHVAMIEAVRITLKNALAMVGVSAPESM
>NC_022113.1|WP_000359082.1|560824_561241_+|DUF1934-domain-containing-protein
MDKKVSIHTKQVLKQHNEKEKFEFTTEGTWQQRQSNFIRYVEQIEDATVNVTIKVDDDSVKLIRKGDINMNLHFVEGQTTTTFYDISAGRIPLEVKTLRILHFVSGDGGKLKIHYELYQDNEKMGSYQYEINYKEIGE
>NC_022113.1|WP_001200748.1|559538_560549_+|alcohol-dehydrogenase-AdhP
MRAAVVTKDHKVSIEDKKLRALKPGEALVQTEYCGVCHTDLHVKNADFGDVTGVTLGHEGIGKVIEVAEDVESLKIGDRVSIAWMFESCGRCEYCTTGRETLCRSVKNAGYTVDGAMAEQVIVTADYAVKVPEKLDPAAASSITCAGVTTYKAVKVSNVKPGQWLGVFGIGGLGNLALQYAKNVMGAKIVAFDINDDKLAFAKELGADAIINSKDVDPVAEVMKLTDNKGLDATVVTSVAKTPFNQAVDVVKAGARVVAVGLPVDKMNLDIPRLVLDGIEVVGSLVGTRQDLREAFEFAAENKVTPKVQLRKLEEINDIFEEMENGTITGRMVIKF
>NC_022113.1|WP_001788287.1|558518_559040_+|YwhD-family-protein
MEVISLSEKKGFNFNIIKNDPLDGHKGTNIGSISLDNIAPVFIDVANKEAFIDIGGMHARAKVEKGVKWITDKAAVEGDEAKEYWLCWVTTERNEQGPYYAGLTACYLLVNKAIRRGYKSMPEHVNMMDKSMKHHIIIDQIGDENKAILKDFLMNHDEGMWKHSSDALHQAFN
>NC_022113.1|WP_000180233.1|557195_558491_+|HD-domain-containing-protein
MTNAYVDLKLVEEKVFKDPIHRYIHVEDQLIWDLIKTKEFQRLRRIRQLGTLYLSFHTAEHSRFGHSLGVYEIVRRLIDESFIGHDAWDNKDRPLALCAALLHDLGHGPFSHSFEKIFNTDHEAYTQAIITGDTEVNAVLRKVSPEFPREVAEVINKTHHNKLVISMISSQIDADRMDYLQRDAYFTGVSYGAFDMERILRLMRPSKDEVLIKESGMHAVENFIMSRYQMYWQIYFHPVSRGGEVLLNNCLKRAKQLYNEGYEFKLHPHDFIPFFEETVTIEQYVELDEAVVTYYLEKWTKEDDAILSDLASRFINRDLFKYIPFDGSIITISELQELFEAGGINPDYYFVSEAFSDLPYDYDRPGSNRKPIHLLRQDGKIREISNQSLVIHSITGINRQDYKLYYPREMVAKIKDKTIREAIENLINELN
>NC_022113.1|WP_000477504.1|556679_557156_+|GNAT-family-N-acetyltransferase
MFKVRQATEKDVVQIRDVATKAWFNTYLNIYAATTVNHLLEASYNEHHLKKRLQEQLFLVVEEGNDIVGFANFIYGEELYLSAHYVKPESQHTGYGTALLNEGLSRFEDKFEGVYLEVDNKNEEAVAYYKEQGFTILRSYEPEMYGEKLDLALMYKAF
>NC_022113.1|WP_000633782.1|555974_556511_+|flavodoxin-family-protein
MITVLFGGSRPNGNTAQLTKFALQDLEYQWIDVTQHQFKPIRDVRHTAETITSYDDDYLPILDKILASDTIIFASPVYWYSISAPLKAFIEHWSETLQDKRYPNFKAQMAEKDFRVILVGGDCPKIKAKPAITQMKYSLDFLGATLNGYIIGTAEKPGDIMKDNYALARATEWNSILQ
>NC_022113.1|WP_000808894.1|554826_555765_+|aldo/keto-reductase
MKQFVNLGKSDVEVFPIALGTNAVGGHNLYPNLDEEQGKDVVRQAINHGINLLDTAYIYGPERSEELVGEVVKEYPREQIKIATKGSHEFDENQEVHQNNQPEYLKQQVENSLKRLQTDYIDLYYIHFPDDNTPKDQAVAALQELKEQGKIKAIGVSNFTLDQLKEANKDGYVDVVQLEYNLLHRENEAVLQYCVDHQITFIPYFPLASGILAGKYDENTKFSDHRTTRRDFKPGVFEENVRRVKALESIAAAHQTSIANIVLAFYLTRPAIDVIIPGAKRAEQVIENIKAADIVLSDDEIQYIDELFPIED
>NC_022113.1|WP_000882189.1|553744_554374_+|DUF443-family-protein
MLCEVIAIYKNPKYRIIKYNDEYLMVNIINNWLVLFIPLLNWLTPKRYIKISQEELENLNTFKPAKNNAFWPALGSSVLFSVTFRKYMPLFNVRLEKTIVIAIFFVVFLGILFFYLNLNRRLALSVFTMNKEKSQKMILLPNLKHFFFIIFAYLYFGGFSFFTLYALITIDVQNIIIFICWGAVTMFFFFINIVPIGIKKAHVILLKKS
>NC_022113.1|WP_000749051.1|564249_565137_+|ABC-transporter-substrate-binding-protein
MKKSLIAFILIFMLVLSGCGMKDNDKQGSDDNGSSKSPYHRIVSLMPSNTEILYELGLGKYIVGVSTVDDYPKDVKKGKKQFDALNLNKEELLKAKPDLILAHESQKATANKVLSSLEKQGIKVVYVKDAQSIDETYNTFKQIGKLTHHEKQAEQLVEETKDNIDKVIDSIPAHHKKSKVFIEVSSKPEIYTAGKHTFFNDMLEKLEAQNVYSDINGWNPVTKESIIKKNPDILISTEAKTRSDYMDIIKKRGGFNKINAVKNTRIEVVNGDEVSRPGPRIDEGLKELRDAIYRK
>NC_022113.1|WP_001820041.1|565286_566237_+|iron-ABC-transporter-permease
MTFNKVLLSWIVILIITTSIYLFWQLGDINDVFNQSILINVRLPRLLEALLTGMILTVAGLIFQTVLNNALADSFTLGLASGATFGSGLALFLGLTTLWIPVFSITFSLITLITVLVITSVLSQGYPVRILILSGLMIGALFNSLLYFLILLKPRKLNTIANYLFGGFGDAEYSNVSIIAITFIIALFGIFIILNQLKLLQLGELKSQSLGLNVQIITYIALCIASMITAINVAYVGIIGFIGMVIPQLIRKWQWKQSLGRQLALNIVIGGQIMVMADFIGSHILSPVQIPASIIIALIGIPVLFYMLISQSKRLH
>NC_022113.1|WP_000365352.1|566291_567011_+|HAD-family-hydrolase
MDLNQIKAVVFDLEGTLLDRVKSREKFIEEQYERFHDYLIHVQLADFKKAFIELDDDEDNDKPDLYKEIIKRFHVDRLTWKDLFNDFEMHFYRYVFPYYDTLYTLEKLSQKGFQIGVIANGKSKIKQFRLHSLGLMHVINYLSTSETVGFRKPHPKIFEDMIDQLGVLPEQIMYVGDDALNDVAPARAMGMVSVWYKQEDAEIEPLEEEVDFTITTVEELLTILPIKIDNKGENYGSIY
>NC_022113.1|WP_000362975.1|566994_567795_+|alpha/beta-hydrolase
MDLFTRKDGTSIHYSTLGEGYPIVLIHTVLDNYSVFNKLAAELAKSFQVVLIDLRGHGYSDKPRHIEIKDFSEDIVELLKYLYIEEVAFVCHEMGGIIGADISVRYPEFTSSLMLVNPTSIEGELPEERLFRKYAHIIRNWDPEKQDKFLNKRKYYRPRKMNRFLKHVVDTNEISTKEEIQAVKEVFKNADISQTYRNVVVPTKIIAGEFGERTTRLEAKEVADLIQNADFEVYQESSAFPFVEEQERFVEDTASFINKHHDEKHV
>NC_022113.1|WP_000735554.1|567930_568437_+|hypothetical-protein
MKKLLTASIIACSVVMGVGIANTSAEAASGNSIDTVKQLIKGDQSLENVKIGESIKDVLTKYKNPMYSYNEDGTEHYYEFHTKKGMLLVTTDGKKNNGKVTHISMMYNDANGPTYQAVKNYVGKAVTHTEYSKVAGNFGYIEKGKTTYQFASAPKDKNIKLYRIDLEK
>NC_022113.1|WP_001222137.1|568598_569315_+|hypothetical-protein
MRINDKILLENIEDYFNHKGLSPHLIDDIKEKVITDIKNSEKKDQDYIEYKRKSPAQIILMIQRNLFALQMNPVIFFIINFILISYLYDKQYVQFQAITGMSLFYCLVIFPMTIVVYLRVSQKNYLRSNKIEMVMGTIIAIISLLLIILQAFNITWGVIPITNFGHQFFFFIGIILVIAGIFYKRLEFSGIGLLFCQKTVDAMIHNPQSAQTFSLIIWILLVVLVIYFTIRLSSRTRL
>NC_022113.1|WP_001045416.1|569483_570272_+|alpha/beta-hydrolase
MNKVTINPQIQLTYQIEGKGDPIILLHGLDGNLAGFEDLQHQLASSYKVITYDLRGHGKSSKSESYDLNDHVEDLKILMEKLNIHEAHILGHDLGGVVAKLFTDKYAYRVKSLTTIASKKDDLIHSFTQLLIQYQDDIAGFNKSEAYILLFSKLFRNQEKTMKWYQKQRIYSIKSEDDSAVAIRSLILHKDEPMYLKKRTCVPTLLINGEHDPLIKDKNHFKLEAHFLNVTKKIFEHSGHAPHIEEPEAFLSYYLNFLKSVS
>NC_022113.1|WP_001018677.1|570521_570896_-|transcriptional-regulator
MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL
>NC_022113.1|WP_001574632.1|571843_572773_-|DMT-family-transporter
MLLFYIIGVLVGMLIPIQTSVNSRLSLYTKSPFYTSFISFSVGTICLIVLNIFINPDVFSLHFFSNQTFNYTWFVGGLLGVGYLTGNLLLLPKLGATLTVIATVAGQIIMGVIIDTFGLFGATIHDFNLIKAIGVLLLIIGIVIMNQFNKNNLLLTDQKYLLFWLLLGFIFGFFPPIQTTINSLLASHTHSPAFASLVSFTIGSITLLILTAIFNRSLKLKTSHLKFGKLKPIYFTGGILGMAFVTSNIILMPHLGAALTTLIGMFGQILMGILIDHFALFGSPKIAMTSRKTIGLLCILTGIIFLRLF
>NC_022113.1|WP_000169038.1|572965_573190_-|DUF2922-domain-containing-protein
MTKTLELSFKSSLDKPVKLQLPQLNNIVTEQVARDSMNALVDLNILKSNSGAITKVHSAQIIDKTTTVLFEAKK

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_022113_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022113_2

628748-628847

Orphan

Consensus_repeat	Method
AAGAGCCCCTAATTAATAAATTAAAAGGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022113_2

>merge|NC_022113|2|628748-628847|CRISPRCasFinder
AAGAGCCCCTAATTAATAAATTAAAAGGGGACTAAAGGAATACAGTTGATTGCTAATGCACCAACAGCAAAAGAGCCCCTAATTAATAAATTAAAAGGGG

>NC_022113|2|2|628748-628847|CRISPRCasFinder
AAGAGCCCCTAATTAATAAATTAAAAGGGG	ACTAAAGGAATACAGTTGATTGCTAATGCACCAACAGCAA
AAGAGCCCCTAATTAATAAATTAAAAGGGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_022113.1\|WP_000081597.1\|621233_621878_+\|Bax-inhibitor-1/YccA-family-protein	unknown	unknown	gnl\|CDD\|223742
NC_022113.1\|WP_031788497.1\|626685_626802_+\|hypothetical-protein	unknown	unknown	unknown
NC_022113.1\|WP_000148818.1\|636029_636488_-\|YaiI/YqxD-family-protein	unknown	unknown	gnl\|CDD\|178882
NC_022113.1\|WP_000865619.1\|626946_627591_+\|DUF402-domain-containing-protein	unknown	unknown	gnl\|CDD\|225188
NC_022113.1\|WP_000842865.1\|632592_633282_-\|DUF1129-family-protein	unknown	unknown	unknown
NC_022113.1\|WP_000687413.1\|627708_628575_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NC_022113.1\|WP_000820892.1\|635461_636028_-\|TIGR00730-family-Rossman-fold-protein	unknown	unknown	gnl\|CDD\|224527
NC_022113.1\|WP_000731642.1\|620075_620873_-\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|226451
NC_022113.1\|WP_000733427.1\|633918_634308_+\|hypothetical-protein	unknown	unknown	unknown
NC_022113.1\|WP_001129756.1\|622559_624710_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197666
NC_022113.1\|WP_000532963.1\|625404_626121_+\|YebC/PmpR-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|237084
NC_022113.1\|WP_001259671.1\|633408_633852_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NC_022113.1\|WP_000158017.1\|630081_630549_+\|DUF456-domain-containing-protein	unknown	unknown	gnl\|CDD\|225395
NC_022113.1\|WP_000367064.1\|628864_630085_+\|sugar-efflux-transporter	unknown	unknown	gnl\|CDD\|341024
NC_022113.1\|WP_001090984.1\|624855_625215_+\|HTH-type-transcriptional-regulator-SarX	unknown	unknown	gnl\|CDD\|130944
NC_022113.1\|WP_000638614.1\|634824_635367_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379112
NC_022113.1\|WP_000120368.1\|618481_619489_+\|inorganic-phosphate-transporter	unknown	unknown	gnl\|CDD\|376541
NC_022113.1\|WP_000545117.1\|634445_634745_+\|hypothetical-protein	unknown	unknown	unknown
NC_022113.1\|WP_000833480.1\|626120_626594_+\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|226072
NC_022113.1\|WP_020967614.1\|630791_632438_+\|IS1182-like-element-ISSau3-family-transposase	unknown	unknown	gnl\|CDD\|226192

Protein	Function_ID	Function_description	E-value
NC_022113.1\|WP_000081597.1\|621233_621878_+\|Bax-inhibitor-1/YccA-family-protein	gnl\|CDD\|223742	COG0670, COG0670, Integral membrane protein, interacts with FtsH [General function prediction only].	2.53359e-32
NC_022113.1\|WP_000148818.1\|636029_636488_-\|YaiI/YqxD-family-protein	gnl\|CDD\|178882	PRK00124, PRK00124, YaiI/YqxD family protein.	1.30275e-76
NC_022113.1\|WP_000865619.1\|626946_627591_+\|DUF402-domain-containing-protein	gnl\|CDD\|225188	COG2306, COG2306, Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only].	6.78593e-91
NC_022113.1\|WP_000638614.1\|634824_635367_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	6.895e-28
NC_022113.1\|WP_000687413.1\|627708_628575_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	6.18267e-39
NC_022113.1\|WP_000731642.1\|620075_620873_-\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|226451	COG3942, COG3942, Surface antigen [General function prediction only].	1.45836e-40
NC_022113.1\|WP_000820892.1\|635461_636028_-\|TIGR00730-family-Rossman-fold-protein	gnl\|CDD\|224527	COG1611, COG1611, Predicted Rossmann fold nucleotide-binding protein [General function prediction only].	1.24037e-61
NC_022113.1\|WP_001129756.1\|622559_624710_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	1.84296e-20
NC_022113.1\|WP_000532963.1\|625404_626121_+\|YebC/PmpR-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|237084	PRK12378, PRK12378, YebC/PmpR family DNA-binding transcriptional regulator.	2.65667e-135
NC_022113.1\|WP_001259671.1\|633408_633852_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	9.08266e-13
NC_022113.1\|WP_000158017.1\|630081_630549_+\|DUF456-domain-containing-protein	gnl\|CDD\|225395	COG2839, COG2839, Uncharacterized protein conserved in bacteria [Function unknown].	1.63066e-45
NC_022113.1\|WP_000367064.1\|628864_630085_+\|sugar-efflux-transporter	gnl\|CDD\|341024	cd17471, MFS_Set, Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters. This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.37741e-101
NC_022113.1\|WP_001090984.1\|624855_625215_+\|HTH-type-transcriptional-regulator-SarX	gnl\|CDD\|130944	TIGR01889, Pleiotropic_Regulator_Of_Virulence, staphylococcal accessory regulator family. This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions].	8.17439e-23
NC_022113.1\|WP_000120368.1\|618481_619489_+\|inorganic-phosphate-transporter	gnl\|CDD\|376541	pfam01384, PHO4, Phosphate transporter family. This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter. This family also contains the leukaemia virus receptor.	5.23541e-104
NC_022113.1\|WP_000833480.1\|626120_626594_+\|cupin-domain-containing-protein	gnl\|CDD\|226072	COG3542, COG3542, Uncharacterized conserved protein [Function unknown].	9.47473e-74
NC_022113.1\|WP_020967614.1\|630791_632438_+\|IS1182-like-element-ISSau3-family-transposase	gnl\|CDD\|226192	COG3666, COG3666, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	1.22931e-37

>NC_022113.1|WP_000687413.1|627708_628575_+|LysR-family-transcriptional-regulator
MKIEDYRLLITLDETKTLRKAAEILYISQPAVTQRLKAIENAFGVDIFIRTKKQLITTTEGTMIIEHARDMLKRERLFFDKMQAHIGEVNGTISIGCSSLIGQTLLPEVLSLYNAQFPNVEIQVQVGSTEQIKANHRDYHVMITRGNKVMNLANTHLFNDDHYFIFPKNRRDDVTKLPFIEFQADPIYINQIKQWYNDNLEQDYHATITVDQVATCKEMLISGVGVTILPEIMMKNISKEQFEFEKVEIDNEPLIRSTFMSYDPSMLQLPQVDSFVNLMTSFVEEPKA
>NC_022113.1|WP_000865619.1|626946_627591_+|DUF402-domain-containing-protein
MKVKYIDKRHWRRLIDREYTEVKVNNNRFKGIIGLVTMKKVRDPLEVTVVGQNIIVADDNYKWLQILPEKKRYSITVMFDNKGNPLEYYFDINIKNITQKGNARTVDLCLDVLALPSGEYELVDEDDLMFALESEQITKKQFHEAYMIAHQIMAELENDFKGFQKKIMYCFNKINAKAQKIHQKPQNKTNFEKSKQIKPKQYNQTKNHQQQKKN
>NC_022113.1|WP_031788497.1|626685_626802_+|hypothetical-protein
MLQLILMKIALNDFEKDKSVLFIFLKNHFYEEMCVLSN
>NC_022113.1|WP_000833480.1|626120_626594_+|cupin-domain-containing-protein
MKSAEQWIDELQLESHPEGGFYRETIREVLKDGRRAPFSSIYFLLTDDNISHFHRIDADEVWYYHAGDSLTIHMINPDGEYTTATLGTDIQNGDVLQYAVPKGTIFASSIEISNTYSLVGCMCQPAFEFKQFELFKQSELITQYPHLKSVIEKYALK
>NC_022113.1|WP_000532963.1|625404_626121_+|YebC/PmpR-family-DNA-binding-transcriptional-regulator
MGRKWNNIKEKKAQKDKNTSRIYAKFGKEIYVAAKSGEPNPESNQALRLVLERAKTYSVPNHIIEKAIDKAKGAGDENFDHLRYEGFAPSGSMLIVDALTNNVNRTASDVRAAFGKNGGNMGVSGSVAYMFDHVATFGIEGKSVDEILETLMEQDVDVNDVIDDNGLTIVYAEPDQFAVVQDALRAAGVEEFKVAEFEMLPQTDIELSEADQVTFEKLIDALEDLEDVQNVFHNVDLK
>NC_022113.1|WP_001090984.1|624855_625215_+|HTH-type-transcriptional-regulator-SarX
MNTEKLETLLGFYKQYKALSEYIDKKYKLSLNDLAVLDLTMKHCKDEKVLMQSFLKTAMDELDLSRTKLLVSIRRLIEKERLSKVRSSKDERKIYIYLNDDDISKFNALFEDVEQFLNI
>NC_022113.1|WP_001129756.1|622559_624710_+|helix-turn-helix-transcriptional-regulator
MAKSCLHILTNNEYATTRCQDGIVLFWPIDGEIELQKFRKSKIIEDDIYIINHLDVFSIKNNKKTIMLYLSSDWFAELGFTFFNYHYTAKLIKSSYNLKCLLLKLTYRYLDNQPLNDADVRKLQDIIKIIAKEASMDKKIAQNQYRYAYYGDLRDELEYIYQNVNQRLTLKSVADKLFVSKSNLSSQFHLLMGMGFKKYIDTLKIGKSIEILLTTDSTISNISEHLGFSSSSTYSKMFKSYMDITPNEYRNLSKFNKSIMLNPEPLVGGMAQEVKEVILNYIDHYKNHLTDVIHIDEDKFEIPKLFQTVIQINTYTEMKLVFLEGLFKTLLNKNSQVVFFIMPSILKSKNTMSEEEKFTIIKTIIESNLKIAFNINDIETTYYVEEAFMNVIRQLSPNEINHHNNYEVHFVFDLSLMEIRTIYRMILKLHNIMLNVKLGLNITCLFDKPSVFKSLVSQIKRLKFDSLIIDNANLSSPYLMGESDELLLKNILHFKNLKQVINELDIEQEKLIFLNVENHKLLNNKERDLSNSAPLIYKTLSALYHNFDGFGLNIFDNHQTFNAMHLYDKNGFKTTLGLILEKFIEYVSKPKYENSYYSIFDIENYYCLVIYDWRVIESETIMSNFEDSQVYINFKNNILNDKYLIVIETLDENSGNINHLISKELRDKYEWNPSLLSKIDNYLKPAIEIKEHNFSNNSLNINVTFNALYIIKIGKK
>NC_022113.1|WP_000081597.1|621233_621878_+|Bax-inhibitor-1/YccA-family-protein
MSQNTNHSYYHQNQHAQAISKVWLYFMYYWIIFGIGCYLGQFLPLSWRQPLSFGLLIIILATLVFERARRFGLIISHIYAVVIGLLSYATFTTYLQNLGPDIFYKNIALAIFAFIAFGIIGYFFVGDASSIGKYLFVTLITLIIASLIGIFLQNPIFYTIITVVSLLLFLLYTLYDFNRLKRGDYSPREMGFNLFINLLNIIKDILYLANMFRR
>NC_022113.1|WP_000731642.1|620075_620873_-|LysM-peptidoglycan-binding-domain-containing-protein
MKKLAFAITATSGAAAFLTHHDAQASTQHTVQSGESLWSIAQKYNTSVESIKQNNQLDNNLVFPGQVISVGGSDAQNTSNTSPQAGSASSHTVQAGESLNIIANRYGVSVDQLMAANNLRGYLIMPNQTLQIPNGGSGGTTPTATTGSNGNASSFNHQNLYTAGQCTWYVFDRRAQAGSPISTYWSDAKYWAGNAANDGYQVNNTPSVGSIMQSTPGPYGHVAYVERVNGDGSILISEMNYTYGPYNMNYRTIPASEVSSYAFIH
>NC_022113.1|WP_000120368.1|618481_619489_+|inorganic-phosphate-transporter
MSYIIIVTIAVVIFSLIFDFINGFHDTANAVATAVSTRALTPKTAILMAAVMNFIGALTFTGVAGTITKDIVDPFKLENGLVVVLAAILAAIIWNLATWFYGIPSSSSHALIGSIAGAAIASEGSFGVLHYQGFTKIIIVLIVSPIIAFCVGFLMYSIFKVIFKNANLTRANRNFRFFQIFTAALQSFSHGTNDAQKSMGIITLALIVANVQNDGSVEPQLWVKFACATAMGLGTAIGGWKIIKTVGGNIMKIRPANGAAADLSSALTIFVASSLHFPLSTTHVVSSSILGVGASNRAKGVKWSTAQRMIITWVITLPISALLAGLLFYILNLFF
>NC_022113.1|WP_000367064.1|628864_630085_+|sugar-efflux-transporter
MDMFAALLQIKNYKLFVANMFLLGMGIAVTVPYLVLFATKDLGMTTNQYGLLLASAAISQFTVNSIIARFSDTHHFNRKIIIILALLMGALGFSIYFFVDTIWLFILLYAIFQGLFAPAMPQLYASARESINVSSSKDRAQFANTVLRSMFSLGFLFGPFIGAQLIGLKGYAGLFGGTISIILFTLVLQVFFYKDLNIKHPISTQQHVEKIAPNMFKDKTLLLPFIAFILLHIGQWMYTMNMPLFVTDYLKENEQHVGYLASLCAGLEVPFMIILGVLSSRLQTRTLLIYGAIFGGLFYFSIGVFKNFYMMLAGQVFLAIFLAVLLGIGISYFQDILPDFPGYASTLFSNAMVIGQLGGNLLGGAMSHWVGLENVFFVSAASIMLGMILIFFTKNQKITKEDVIST
>NC_022113.1|WP_000158017.1|630081_630549_+|DUF456-domain-containing-protein
MTIVLWLLIIAAFMLAFVGLIKPIIPSVLVLWVGFLIYQFGFHNQHLSWVFYVSMALLTILILCADFLANKYFVNRFGGSKFGEYAALIGVVIGCFVLPPFGIIIIPFILVFIVELIQGYSFERAVKVSIGSIVAFLTSSIAQASLEHKSLKKQQ
>NC_022113.1|WP_020967614.1|630791_632438_+|IS1182-like-element-ISSau3-family-transposase
MYKNYNMTQLTLPIETSVRIPQNDISRYVNEIVETIPDSEFDEFRHHRGATSYHPKMMLKIILYAYTQSVFSGRRIEKLLHDSIRMMWLAQNQTPSYKTINRFRVNPNTDALIESLFIQFHSQCLKQNLIDDSSIFIDGTKVEANANRYTFVWKKSIQNHESKLNENSKALYRDLVEEKIIPEIKEDGDSDLTIEEIDLIGSHLDKEIEDLNHSIQNEDCTQIRKQTRKKRTEIKKFKKKFDDYSERKSKYEEQKSILKDRNSFSKTDHDATFMRMKEDHMKNGQLKPGYNLQIATNSQFVLSYDLFQNPTDTRTLIPFLTMIQNTFGYLPEYIVADAGYGSEQNYMAIIDDFNKTPLITYGMFIKDKTRKFKSDIFNTQNWKYDELNDEFICPNNKRIGFKRYAYRNNRYGFKRDFKLYECDDCSACSLRQQCMKPNSKSNKKIMKNYNWEYFKAQINQKLSEPETKKIYSQRKIDVEPVFGFMKAILGFTRMSVRGINKVKRELGFVLMALNIRKIVARRAVYYQIHLKKADFYQIINRNQLFYIA
>NC_022113.1|WP_000842865.1|632592_633282_-|DUF1129-family-protein
MKSTAQLTKENNVKSLRLSNTDREIFENYMTYMRSDFRVNPHDTELIINRILKQLLSAEQHGLLALDFFNHDPKAHAIKELKAMPNETFKNIFKYIYQHIVLLIGIVSFLKGFLGFFMEKSGSNLYFVSFPFSVVVGFFIVFLFIWFSFKTIQLQCFNNSNWIWIFTYLAIILLIVGFFYVFFIPQSLLAFGPYIQVSNWVFIIFSFIVMPIGLRIERNISKKHSHTFL
>NC_022113.1|WP_001259671.1|633408_633852_+|GNAT-family-N-acetyltransferase
MRTLNKDEHNYIKQIANIHETLLSQAESNYKCTKLSIALRYEMICSNLEHTNDKIYIYENEGQLIAFIWGHFSNEKSMVNIELLYVEPQFRKLGIATQLKIALEKWAKTMNAKRISSTIHKSNLPMISLNKDLGYQVSHVKMYKDID
>NC_022113.1|WP_000733427.1|633918_634308_+|hypothetical-protein
MKKLIISIMAIMLFLTGCGKSQEKATLEKDIDNLQKENKELKDKKEKLQQEKEKLADKQKDLEKEVKDLKPSKEDNKDDKKDEDKNKDKDKEASQDKQSKDQTKSSDKDNHKKPTSTDKDQKANDKHQS
>NC_022113.1|WP_000545117.1|634445_634745_+|hypothetical-protein
MHEQDFRILEGQDITLPELGRELENITGRTIADSTGEIKRVIVHLPNFESDTDTFVATYRLNHQQDFIDATFTALKSDRARLKEVPVHVELISYISKSK
>NC_022113.1|WP_000638614.1|634824_635367_+|GNAT-family-N-acetyltransferase
MIYCETERLILRDWHEDDLLPFQKMNANYDVRKYFPSLLSYRRSELDMRTMDAVIKDYGIGLFAVEDKESHQWIGFIGLNYIPETSDYPFKELPLYEIGWRLLPEFWGKGLATEGAKATLKLAEQHQIYDVYSFTAEANKASQRVMEKIGMTVYDHFELPNLSKYHLLKRQVRYYINLRK
>NC_022113.1|WP_000820892.1|635461_636028_-|TIGR00730-family-Rossman-fold-protein
MKRIAVYCGASKGHDPSYVQKAYDLGKYFAEQGYELVFGAGSIGIMGAIQDGVLDHGGKAIGVMPKMLDEHEITSQRLTELILVDSMHERKNKMAELADAFVMAPGGAGSLEEFFEMYSWAQIGIHEKPIAIYNINGFFNPLQTMIDHMIEEGFIDPKYRALAPLCDTKESLIESILNFKPLGTRSYD
>NC_022113.1|WP_000148818.1|636029_636488_-|YaiI/YqxD-family-protein
MTHIIIDGDACPVVDSIIDLTTETGIFVTIIRSFSHFSNQLYPPHVSTLYVDDGPDAVDYKIIQLSTKDDIVITQDYGLASLLVDKVLIVMHHNGKIYNSKNIQQLLDKRYMNAQIRKQGGRHKGPPPFTKQDQKVFEKSLLRVIHRIKELD

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Crispr_ID: NC_022113_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022113_3

716482-716566

Unclear

Consensus_repeat	Method
CACCCCAACTTGCATTGTCTGTAGAA	CRISPRCasFinder

1 spacers

cas3

The CRISPR arrays of NC_022113_3

>merge|NC_022113|3|716482-716566|CRISPRCasFinder
CACCCCAACTTGCATTGTCTGTAGAAATTGGGAATCCAATTTCTCTTTGTTGGGGCCCACACCCCAACTTGCATTGCCTGTAGAA

>NC_022113|3|3|716482-716566|CRISPRCasFinder
CACCCCAACTTGCATTGTCTGTAGAA	ATTGGGAATCCAATTTCTCTTTGTTGGGGCCCA
CACCCCAACTTGCATTGCCTGTAGAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_022113.1\|WP_000617735.1\|711363_711936_+\|ribosome-associated-translation-inhibitor-RaiA	unknown	unknown	gnl\|CDD\|224461
NC_022113.1\|WP_000958224.1\|724689_725622_+\|HPr-kinase/phosphorylase	unknown	unknown	gnl\|CDD\|235459
NC_022113.1\|WP_000369719.1\|730180_731092_+\|RNase-adapter-RapZ	unknown	unknown	gnl\|CDD\|224574
NC_022113.1\|WP_000370984.1\|709552_710635_+\|DEAD/DEAH-box-helicase	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|226583
NC_022113.1\|WP_000538141.1\|718087_718738_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|378993
NC_022113.1\|WP_000229253.1\|719239_721225_+\|excinuclease-ABC-subunit-UvrB	unknown	unknown	gnl\|CDD\|235395
NC_022113.1\|WP_000662687.1\|721232_724079_+\|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl\|CDD\|234734
NC_022113.1\|WP_000749385.1\|717074_717914_+\|CHAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|226451
NC_022113.1\|WP_000638419.1\|718734_718971_+\|CsbA-family-protein	unknown	unknown	gnl\|CDD\|227234
NC_022113.1\|WP_000258151.1\|706318_707374_+\|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	unknown	unknown	gnl\|CDD\|133463
NC_022113.1\|WP_000686342.1\|708322_709189_+\|DegV-family-protein	unknown	unknown	gnl\|CDD\|273257
NC_022113.1\|WP_000134963.1\|728477_729413_+\|thioredoxin-disulfide-reductase	unknown	unknown	gnl\|CDD\|273540
NC_022113.1\|WP_000506536.1\|712349_714881_+\|preprotein-translocase-subunit-SecA	unknown	unknown	gnl\|CDD\|237259
NC_022113.1\|WP_001791369.1\|714922_715021_+\|hypothetical-protein	unknown	unknown	unknown
NC_022113.1\|WP_000460983.1\|704930_706001_-\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NC_022113.1\|WP_001113406.1\|703973_704735_-\|threonine/serine-exporter-ThrE-family-protein	unknown	unknown	gnl\|CDD\|225514
NC_022113.1\|WP_098827697.1\|715195_716306_+\|peptide-chain-release-factor-2	unknown	unknown	gnl\|CDD\|234799
NC_022113.1\|WP_000508984.1\|725627_726470_+\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|183527
NC_022113.1\|WP_000192947.1\|707537_708179_-\|YigZ-family-protein	unknown	unknown	gnl\|CDD\|224653
NC_022113.1\|WP_001224791.1\|726477_726963_+\|acetyltransferase	unknown	unknown	gnl\|CDD\|100053

Protein	Function_ID	Function_description	E-value
NC_022113.1\|WP_000617735.1\|711363_711936_+\|ribosome-associated-translation-inhibitor-RaiA	gnl\|CDD\|224461	COG1544, COG1544, Ribosome-associated protein Y (PSrp-1) [Translation, ribosomal structure and biogenesis].	1.13584e-37
NC_022113.1\|WP_000958224.1\|724689_725622_+\|HPr-kinase/phosphorylase	gnl\|CDD\|235459	PRK05428, PRK05428, HPr kinase/phosphorylase; Provisional.	1.22623e-170
NC_022113.1\|WP_000369719.1\|730180_731092_+\|RNase-adapter-RapZ	gnl\|CDD\|224574	COG1660, COG1660, Predicted P-loop-containing kinase [General function prediction only].	2.63933e-170
NC_022113.1\|WP_000370984.1\|709552_710635_+\|DEAD/DEAH-box-helicase	gnl\|CDD\|226583	COG4098, comFA, Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair].	1.30855e-179
NC_022113.1\|WP_000538141.1\|718087_718738_+\|HD-domain-containing-protein	gnl\|CDD\|378993	pfam12917, HD_2, HD containing hydrolase-like enzyme. This is a family of bacterial and archaeal hydrolases.	6.51021e-58
NC_022113.1\|WP_000662687.1\|721232_724079_+\|excinuclease-ABC-subunit-UvrA	gnl\|CDD\|234734	PRK00349, uvrA, excinuclease ABC subunit UvrA.	0
NC_022113.1\|WP_000749385.1\|717074_717914_+\|CHAP-domain-containing-protein	gnl\|CDD\|226451	COG3942, COG3942, Surface antigen [General function prediction only].	3.29354e-42
NC_022113.1\|WP_000229253.1\|719239_721225_+\|excinuclease-ABC-subunit-UvrB	gnl\|CDD\|235395	PRK05298, PRK05298, excinuclease ABC subunit UvrB.	0
NC_022113.1\|WP_000258151.1\|706318_707374_+\|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	gnl\|CDD\|133463	cd06853, GT_WecA_like, This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate molecule and N-acetylglucosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylglucosamine precursor. WecA participates in the biosynthesis of O antigen LPS in many enteric bacteria and is also involved in the biosynthesis of enterobacterial common antigen. A conserved short sequence motif and a conserved arginine at a cytosolic loop of this integral membrane protein were shown to be critical in recognition of substrate UDP-N-acetylglucosamine.	2.69988e-87
NC_022113.1\|WP_000686342.1\|708322_709189_+\|DegV-family-protein	gnl\|CDD\|273257	TIGR00762, DegV, EDD domain protein, DegV family. This family of proteins is related to DegV of Bacillus subtilis and includes paralogous sets in several species (B. subtilis, Deinococcus radiodurans, Mycoplasma pneumoniae) that are closer in percent identity to each than to most homologs from other species. This suggests both recent paralogy and diversity of function. DegV itself is encoded immediately downstream of DegU, a transcriptional regulator of degradation, but is itself uncharacterized. Crystallography suggested a lipid-binding site, while comparison of the crystal structure to dihydroxyacetone kinase and to a mannose transporter EIIA domain suggests a conserved domain, EDD, with phosphotransferase activity. [Unknown function, General].	9.17692e-120
NC_022113.1\|WP_000134963.1\|728477_729413_+\|thioredoxin-disulfide-reductase	gnl\|CDD\|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	4.19425e-154
NC_022113.1\|WP_000506536.1\|712349_714881_+\|preprotein-translocase-subunit-SecA	gnl\|CDD\|237259	PRK12904, PRK12904, preprotein translocase subunit SecA; Reviewed.	0
NC_022113.1\|WP_000638419.1\|718734_718971_+\|CsbA-family-protein	gnl\|CDD\|227234	COG4897, CsbA, Uncharacterized protein conserved in bacteria [Function unknown].	4.73465e-34
NC_022113.1\|WP_000460983.1\|704930_706001_-\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	1.2404e-45
NC_022113.1\|WP_001113406.1\|703973_704735_-\|threonine/serine-exporter-ThrE-family-protein	gnl\|CDD\|225514	COG2966, COG2966, Uncharacterized conserved protein [Function unknown].	1.53065e-80
NC_022113.1\|WP_098827697.1\|715195_716306_+\|peptide-chain-release-factor-2	gnl\|CDD\|234799	PRK00578, prfB, peptide chain release factor 2; Validated.	0
NC_022113.1\|WP_000508984.1\|725627_726470_+\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|183527	PRK12437, PRK12437, prolipoprotein diacylglyceryl transferase; Reviewed.	6.12313e-120
NC_022113.1\|WP_000192947.1\|707537_708179_-\|YigZ-family-protein	gnl\|CDD\|224653	COG1739, COG1739, Uncharacterized conserved protein [Function unknown].	7.46066e-72
NC_022113.1\|WP_001224791.1\|726477_726963_+\|acetyltransferase	gnl\|CDD\|100053	cd04647, LbH_MAT_like, Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively while GAT specifically acetylates galactopyranosides. XAT catalyzes the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and streptogramin, among others. XATs are implicated in inactivating xenobiotics leading to xenobiotic resistance in patients. Members of this family contain a a left-handed parallel beta-helix (LbH) domain with at least 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). They are trimeric in their active form.	7.57447e-30

>NC_022113.1|WP_098827697.1|715195_716306_+|peptide-chain-release-factor-2
MELSEIKRNIDKYNQDLTQIRGSLDLENKETNIQEYEEMMAEPNFWDNQTKAQDIIDKNNALKAIVNGYKTLQAEVDDMDATWDLLQEEFDGEMKEDLEQEVINFKAKVDEYELQLLLDGPHDANNAILELHPGAGGTESQDWANMLFRMYQRYCEKKGFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFASCDVIPDFNNDEIEIEINPDDITVDTFRASGAGGQHINKTESAIRITHHPSGIVVNNQNERSQIKNREAAMKMLKSKLYQLKLEEQAREMAEIRGEQKEIGWGSQIRSYVFHPYSMVKDHRTNEETGKVDAVMDGDIGPFIESYLRQTMSHD
>NC_022113.1|WP_001791369.1|714922_715021_+|hypothetical-protein
MLWEESFYFTSVKYFKKCEEVVKRCYVLSLKK
>NC_022113.1|WP_000506536.1|712349_714881_+|preprotein-translocase-subunit-SecA
MGFLSKILDGNNKEIKQLGKLADKVIALEEKTAILTDEEIRNKTKQFQTELADIDNVKKQNDYLDKILPEAYALVREGSKRVFNMTPYKVQIMGGIAIHKGDIAEMRTGEGKTLTATMPTYLNALAGRGVHVITVNEYLSSVQSEEMAELYNFLGLTVGLNLNSKTTEEKREAYAQDITYSTNNELGFDYLRDNMVNYSEDRVMRPLHFAIIDEVDSILIDEARTPLIISGEAEKSTSLYTQANVFAKMLKQDEDYKYDEKTKSVHLTEQGADKAERMFKVENLYDVQNVDVISHINTALRAHVTLQRDVDYMVVDGEVLIVDQFTGRTMPGRRFSEGLHQAIEAKEGVQIQNESKTMASITFQNYFRMYNKLAGMTGTAKTEEEEFRNIYNMTVTQIPTNKPVQRNDKSDLIYISQKGKFDAVVEDVVEKHKAGQPVLLGTVAVETSEYISNLLKKRGIRHDVLNAKNHEREAEIVAGAGQKGAVTIATNMAGRGTDIKLGEGVEELGGLAVIGTERHESRRIDDQLRGRSGRQGDKGDSRFYLSLQDELMIRFGSERLQKMMSRLGLDDSTPIESKMVSRAVESAQKRVEGNNFDARKRILEYDEVLRKQREIIYNERNSIIDEEDSSQVVDAMLRSTLQRSINYYINTADDEPEYQPFIDYINDIFLQEGDITEDDIKGKDAEDIFEVVWAKIEAAYQSQKDILEEQMNEFERMILLRSIDSHWTDHIDTMDQLRQGIHLRSYAQQNPLRDYQNEGHELFDIMMQNIEEDTCKFILKSVVQVEDNIEREKTTEFGEAKHVSAEDGKEKVKPKPIVKGDQVGRNDDCPCGSGKKFKNCHGK
>NC_022113.1|WP_000617735.1|711363_711936_+|ribosome-associated-translation-inhibitor-RaiA
MIRFEIHGDNLTITDAIRNYIEEKIGKLERYFNDVPNAVAHVKVKTYSNSATKIEVTIPLKNVTLRAEERNDDLYAGIDLINNKLERQVRKYKTRINRKSRDRGDQEVFVAELQEMQETQVDNDAYDDNEIEIIRSKEFSLKPMDSEEAVLQMNLLGHDFFVFTDRETDGTSIVYRRKDGKYGLIQTSEQ
>NC_022113.1|WP_000370984.1|709552_710635_+|DEAD/DEAH-box-helicase
MDNVTRYKITESSQSSSQAYYHLSFELSEQQSYASEHIVRAIRMRQTILLYAVTGAGKTEMMFQGIQYARRQGDNIAIVSPRVDVVVEISKRIKDAFLNEDIDILHQQSSQQFEGHFVVCTVHQLYRFKQHFDTIFIDEVDAFPLSMDKSLQQALKSSSKVEHATIYMTATPPKQLLSEIPLENIIKLPARFHKKSLPVPKYRYFKLNNNKIQKMLYRILQDQINNQRYTLVFFNNIETMIKTFSIYKQKITKLTYVHSEDVFRFEKVEQLRNGQYDVIFTTTILERGFTMANLDVVVIDAHQYTQEALIQIAGRVGRKLECPTGKVLFFHEGVSMNMIQAKKEIQKMNKLALKRGWIDE
>NC_022113.1|WP_000686342.1|708322_709189_+|DegV-family-protein
MKIAVMTDSTSYLSQDLIDKYNIQIAPLSVTFDDGKNFTESNEIAIEEFYNKMASSQTIPTTSQPAIGEWITKYEMLRDQGYTDIIVICLSSGISGSYQSSYQAGEMVEGVNVHAFDSKLAAMIEGCYVLRAIEMVEEGYEPQQIIDDLTNMREHTGAYLIVDDLKNLQKSGRITGAQAWVGTLLKMKPVLKFEDGKIIPEEKVRTKKRAIQTLEKKVLDIVKDFEEVTLFVINGDHFEDGQALYKKLQDDCPSAYQVAYSEFGPVVAAHLGSGGLGLGYVGRKIRLT
>NC_022113.1|WP_000192947.1|707537_708179_-|YigZ-family-protein
MTQNIITVKKEHIIENVISKSRFIAHIKPVQNEDEAKAFIAAIKKEHKDATHNCSAYTIGPEMNIQKANDDGEPTGTAGVPMLDILKKLDVHNACVVVTRYFGGIKLGGGGLIRAYSGAVRDVIYDIGRVELREAVPCIVTLNYDQTGKFEYELASTHFMLRNQTYTDKVSYYIDVVKSDYEAFINFLNQMTAGNFDLTEETPKQLPFDIPTE
>NC_022113.1|WP_000258151.1|706318_707374_+|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase
MVTLLLVAVTMIVSLTITPIVIAISKRLNLVDKPNFRKVHTKPISVMGGTVILFSFLIGIWIGHPIETEIKPLIIGAIIMYVLGLVDDIYDLKPYIKLAGQIAAALVVAFYGVTIDFISLPMGTTIHFGFLSIPITVIWIVAITNAINLIDGLDGLASGVSAIGLITIGFIAILQANIFITMICCVLLGSLIGFLFYNFHPAKIFLGDSGALMIGFIIGFLSLLGFKNITIIALFFPIVILAVPFIDTLFAMIRRVKKGQHIMQADKSHLHHKLLALGYTHRQTVLLIYSISILFSLSSIILYVSPPLGVVLMFVLIIFSIELIVEFTGLIDNNYRPILNLISRKSSHKEE
>NC_022113.1|WP_000460983.1|704930_706001_-|GGDEF-domain-containing-protein
MFEAFIYNISVIVAGIYLFHRLQYSENKRMVFSKAYVTVLMTIVSLLLSVYPIPYREDYLIHLTFVPLLFLGRFTNMVYTLSATVIVAIVEIVVFNNSIMYGVTLIVIAAVTSAIGPFLKQNDVLSLLILNVVTIIILFGVALVSPIYTLSEVIILIPISLIITLASAITFVDIWHFFSLVNRYENEDKYDYLTGLGNVKEFDRHLNEISRKAEKEHQSIALLLIDIDGFKDVNDTYSHKSGDAVLKQMSQLLKNYVPNQFKIFRNGGEEFSVVIHNYSLDQSVKLAENIRSGVEKSSFHLPNKEVIKLSVSIGVGYLTDDDPKSQRKVFKDADDMVHVAKNQGRNKVMFNPIINL
>NC_022113.1|WP_001113406.1|703973_704735_-|threonine/serine-exporter-ThrE-family-protein
MPDSITIIDENKVIDVVLIAGRILLESGAETYRVEDTMNRIAHSYGLHNTYSFVSSTAIIFSLNDRTSTRLIRVQERTTDLEKIALTNSLSRKISNKELTIDEAKSEFIHLQHASLQYSFLTNFFAAAIACGFFLFMFGGVASDCWIAVIAGGSAFLTFSFVQRYIQIKFFSEFVAAAVVISIAATFTKLGIATNQDIITIASVMPLVPGILITNAIRDLLAGELLAGMSRGVEAALTAFAIGAGVAIVLLII
>NC_022113.1|WP_000749385.1|717074_717914_+|CHAP-domain-containing-protein
MKKSLTVTVSSVLAFLALNNAAHAQQHGTQVKTPVQHNYVSNVQAQTQSPTTYTVVAGDSLYKIALEHHLTLNQLYSYNPGVTPLIFPGDVISLVPQNKVKQTKTVKSPVRKASQAKKVVQQPVQQASKKVVVKQAPKQTVAKTVNVAYKPAQVQKSVPTVPVAHNYNKSVANRGNLYAYGNCTYYAFDRRAQLGRSIGSLWGNANNWNYAAKVAGFKVDKTPEVGAIFQTAAGPYGHVGVVESVNPNGTITVSEMNYAGFNVKSSRTILNPGKYNYIH
>NC_022113.1|WP_000538141.1|718087_718738_+|HD-domain-containing-protein
MGVHQYFKRLSDMERLIRLPGKFKYFEHNVAAHSFKVTKIAQYLATVEEYHGRKINWKSLYEKALNHDFAEVFTGDIKTPVKYASSELKKLFSQVEEEMVETFIEEEIPLQYRDVYKQRLQEGKDDSLEGQILSVADKIDLLYETFGEIQKRNPEELFFEIYEMSLETIIQFDHLASVQDFINNIIPEMLTENFIPRTELRETTMNILNKRKEENE
>NC_022113.1|WP_000638419.1|718734_718971_+|CsbA-family-protein
MIWYFSAAFFPCVLVVLFSVITRSKWVGTILTLILIGASIYKEYFHNEWIIFIDVVSLLAGYLIIDQLEFHKHQDEDR
>NC_022113.1|WP_000229253.1|719239_721225_+|excinuclease-ABC-subunit-UvrB
MVEHYPFKIHSDFEPQGDQPQAIKEIVEGIKAGKRHQTLLGATGTGKTFTMSNVIKEVGKPTLIIAHNKTLAGQLYSEFKEFFPENRVEYFVSYYDYYQPEAYVPSTDTFIEKDASINDEIDQLRHSATSALFERDDVIIIASVSCIYGLGNPEEYKDLVVSVRVGMEMDRSELLRKLVDVQYTRNDIDFQRGTFRVRGDVVEIFPASKEELCIRVEFFGDEIDRIREVNYLTGEVLKEREHFAIFPASHFVTREEKLKVAIERIEKELEERLKELRDENKLLEAQRLEQRTNYDLEMMREMGFCSGIENYSVHLTLRPLGSTPYTLLDYFGDDWLVMIDESHVTLPQVRGMYNGDRARKQVLVDHGFRLPSALDNRPLKFEEFEEKTKQLVYVSATPGPYEIEHTDKMVEQIIRPTGLLDPKIEVRPTENQIDDLLSEIQTRVERNERVLVTTLTKKMSEDLTTYMKEAGIKVNYLHSEIKTLERIEIIRDLRMGTYDVIVGINLLREGIDIPEVSLVVILDADKEGFLRSNRSLIQTIGRAARNDKGEVIMYADKMTDSMKYAIDETQRRREIQMKHNEKHGITPKTINKKIHDLISATVENDENNDKAQTVIPKKMTKKERQKTIDNIEKEMKQAAKDLDFEKATELRDMLFELKAEG
>NC_022113.1|WP_000662687.1|721232_724079_+|excinuclease-ABC-subunit-UvrA
MKEPSIVVKGARAHNLKDIDIELPKNKLIVMTGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLGQMDKPDVDTIEGLSPAISIDQKTTSKNPRSTVATVTEIYDYIRLLYARVGKPYCPNHNIEIESQTVQQMVDRIMELEARTKIQLLAPVIAHRKGSHEKLIEDIGKKGYVRLRIDGEIVDVNDVPTLDKNKNHTIEVVVDRLVVKDGIETRLADSIETALELSEGQLTVDVIDGEDLKFSESHACPICGFSIGELEPRMFSFNSPFGACPTCDGLGQKLTVDVDLVVPDKDKTLNEGAIEPWIPTSSDFYPTLLKRVCEVYKINMDKPFKKLTERQRDILLYGSGDKEIEFTFTQRQGGTRKRTMVFEGVVPNISRRFHESPSEYTREMMSKYMTELPCETCHGKRLSREALSVYVGGLNIGEVVEYSISQALNYYKNINLSEQDQAIANQILKEIISRLTFLNNVGLEYLTLNRASGTLSGGEAQRIRLATQIGSRLTGVLYVLDEPSIGLHQRDNDRLINTLKEMRDLGNTLIVVEHDDDTMRAADYLVDIGPGAGEHGGQIVSSGTPQKVMKDKKSLTGQYLSGKKRIEVPEYRRPASDRKISIRGARSNNLKGVDVDIPLSIMTVVTGVSGSGKSSLVNEVLYKSLAQKINKSKVKPGLYDKIEGIDQLDKIIDIDQSPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKIRGYQKGRFSFNVKGGRCEACKGDGIIKIEMHFLPDVYVPCEVCDGKRYNRETLEVTYKGKNIADILEMTVEEATQFFENIPKIKRKLQTLVDVGLGYVTLGQQATTLSGGEAQRVKLASELHKRSTGKSIYILDEPTTGLHVDDISRLLKVLNRLVENGDTVVIIEHNLDVIKTADYIIDLGPEGGSGGGTIVATGTPEDIAQTKSSYTGKYLKEVLERDKQNTEDK
>NC_022113.1|WP_000958224.1|724689_725622_+|HPr-kinase/phosphorylase
MLTTEKLVETLKLDLIAGEEGLSKPIKNADISRPGLEMAGYFSHYASDRIQLLGTTELSFYNLLPDKDRAGRMRKLCRPETPAIIVTRGLQPPEELVEAAKELNTPLIVAKDATTSLMSRLTTFLEHALAKTTSLHGVLVDVYGVGVLITGDSGIGKSETALELVKRGHRLVADDNVEIRQINKDELIGKPPKLIEHLLEIRGLGIINVMTLFGAGSILTEKRIRLNINLENWNKQKLYDRVGLNEETLSILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAEEFSERLNEEIIKNSHKSEE
>NC_022113.1|WP_000508984.1|725627_726470_+|prolipoprotein-diacylglyceryl-transferase
MGGIVFNYIDPVAFNLGPLSVRWYGIIIAVGILLGYFVAQRALVKAGLHKDTLVDIIFYSALFGFIAARIYFVIFQWPYYAENPGEIIKIWHGGIAIHGGLIGGFIAGVIVCKVKNLNPFQIGDIVAPSIILAQGIGRWGNFMNHEAHGGPVSRAFLEQLHLPNFIIENMYINGQYYHPTFLYESIWDVAGFIILVNIRKHLKLGETFFLYLTWYSIGRFFIEGLRTDSLMLTSNIRVAQLVSILLILISISLIVYRRIKYNPPLYSKVGALPWPTRKVK
>NC_022113.1|WP_001224791.1|726477_726963_+|acetyltransferase
MRKFLSKEYHRTNPLWHVYRLVKFSKVFKNVIIIEFSKFIPSMVLKRHIYKQILNINIGNQSSIAYKVMLDIFYPELITIGSNSVIGYNVTILTHEALVDEFRYGPVTIGSNTLIGANATILPGITIGDNVKVAAGTVVSKDIPDNGFAYGNPMYIKMIRR
>NC_022113.1|WP_000134963.1|728477_729413_+|thioredoxin-disulfide-reductase
MTEIDFDIAIIGAGPAGMTAAVYASRANLKTVMIERGIPGGQMANTEEVENFPGFEMITGPDLSTKMFEHAKKFGAVYQYGDIKSVEDKGEYKVINFGNKELTAKAVIIATGAEYKKIGVPGEQELGGRGVSYCAVCDGAFFKNKRLFVIGGGDSAVEEGTFLTKFADKVTIVHRRDELRAQRILQDRAFKNDKIDFIWSHTLKSINEKDGKVGSVTLTSTKDGSEETHEADGVFIYIGMKPLTAPFKDLGITNDVGYIVTKDDMTTSVPGIFAAGDVRDKGLRQIVTATGDGSIAAQSAAEYIEHLNDQA
>NC_022113.1|WP_000369719.1|730180_731092_+|RNase-adapter-RapZ
MDNNEKEKSKSELLVVTGLSGAGKSLVIQCLEDMGYFCVDNLPPVLLPKFVELMEQGNPSLRKVAIAIDLRGKELFNSLVAVVDKVKSESDVIIDVMFLEASTEKLISRYKETRRAHPLMEQGKKSLINAINDEREHLSQIRSIANFVIDTTKLSPKELKERIRRYYEDEEFETFTINVTSFGFKHGIQMDADLVFDVRFLPNPYYVVDLRPLTGLDKDVYNYVMKWKETEIFFEKLTDLLDFMIPGYKKEGKSQLVIAIGCTGGQHRSVALAERLGNYLNEVFEYNVYVHHRDAHIESGEKK

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Crispr_ID: NC_022113_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022113_4

774814-774893

Orphan

Consensus_repeat	Method
CCGTCAGCTTCTGTGTTGGGGCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022113_4

>merge|NC_022113|4|774814-774893|CRISPRCasFinder
CCGTCAGCTTCTGTGTTGGGGCCCACCCCAACTTGCATTGCTTGTAAGCTGACTTTCCGTCAGCTTCTATGTTGGGGCCC

>NC_022113|4|4|774814-774893|CRISPRCasFinder
CCGTCAGCTTCTGTGTTGGGGCCC	ACCCCAACTTGCATTGCTTGTAAGCTGACTTT
CCGTCAGCTTCTATGTTGGGGCCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_022113.1\|WP_000571222.1\|776074_777100_+\|methionine-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224058
NC_022113.1\|WP_001147955.1\|772145_772466_-\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239245
NC_022113.1\|WP_001065804.1\|775528_775825_+\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239245
NC_022113.1\|WP_000290491.1\|773123_773504_+\|glycine-cleavage-system-protein-GcvH	unknown	unknown	gnl\|CDD\|234918
NC_022113.1\|WP_000520233.1\|777092_777788_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224922
NC_022113.1\|WP_000732338.1\|777805_778627_+\|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224381
NC_022113.1\|WP_000150025.1\|770657_771374_+\|type-I-3-dehydroquinate-dehydratase	unknown	unknown	gnl\|CDD\|184156
NC_022113.1\|WP_000589549.1\|772609_772966_+\|arsenate-reductase-family-protein	unknown	unknown	gnl\|CDD\|239334
NC_022113.1\|WP_000560872.1\|782162_782384_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224393
NC_022113.1\|WP_000255542.1\|768421_769039_-\|amino-acid-transporter	unknown	unknown	gnl\|CDD\|224198
NC_022113.1\|WP_001018965.1\|775149_775536_+\|topiosmerase	unknown	unknown	gnl\|CDD\|224572
NC_022113.1\|WP_000974455.1\|770087_770510_-\|organic-hydroperoxide-resistance-protein	unknown	unknown	gnl\|CDD\|274649
NC_022113.1\|WP_025173845.1\|780003_781392_-\|SAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|366887
NC_022113.1\|WP_001661454.1\|781418_781991_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NC_022113.1\|WP_000270271.1\|778769_779990_-\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271189
NC_022113.1\|WP_000124597.1\|782384_782657_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379251
NC_022113.1\|WP_001140696.1\|767767_768349_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|223483
NC_022113.1\|WP_000422908.1\|771456_771996_+\|nitroreductase	unknown	unknown	gnl\|CDD\|380312
NC_022113.1\|WP_001794224.1\|773681_774560_+\|DUF1963-domain-containing-protein	unknown	unknown	gnl\|CDD\|226395
NC_022113.1\|WP_000569884.1\|769194_769689_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|372596

Protein	Function_ID	Function_description	E-value
NC_022113.1\|WP_000571222.1\|776074_777100_+\|methionine-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224058	COG1135, AbcC, ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism].	4.22222e-169
NC_022113.1\|WP_001147955.1\|772145_772466_-\|thioredoxin-family-protein	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	3.63533e-24
NC_022113.1\|WP_001065804.1\|775528_775825_+\|thioredoxin-family-protein	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	1.8621e-13
NC_022113.1\|WP_000290491.1\|773123_773504_+\|glycine-cleavage-system-protein-GcvH	gnl\|CDD\|234918	PRK01202, PRK01202, glycine cleavage system protein GcvH.	9.01516e-70
NC_022113.1\|WP_000520233.1\|777092_777788_+\|ABC-transporter-permease	gnl\|CDD\|224922	COG2011, AbcD, ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism].	9.67625e-100
NC_022113.1\|WP_000732338.1\|777805_778627_+\|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein	gnl\|CDD\|224381	COG1464, NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism].	5.3847e-113
NC_022113.1\|WP_000150025.1\|770657_771374_+\|type-I-3-dehydroquinate-dehydratase	gnl\|CDD\|184156	PRK13575, PRK13575, type I 3-dehydroquinate dehydratase.	7.88423e-148
NC_022113.1\|WP_000589549.1\|772609_772966_+\|arsenate-reductase-family-protein	gnl\|CDD\|239334	cd03036, ArsC_like, Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX) function as protein disulfide oxidoreductases, altering the redox state of target proteins via the reversible oxidation of the active site dithiol. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from glutathione via GRX, through a single catalytic cysteine.	1.06191e-56
NC_022113.1\|WP_000560872.1\|782162_782384_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224393	COG1476, COG1476, Predicted transcriptional regulators [Transcription].	2.70121e-07
NC_022113.1\|WP_000255542.1\|768421_769039_-\|amino-acid-transporter	gnl\|CDD\|224198	COG1279, COG1279, Lysine efflux permease [General function prediction only].	2.54276e-60
NC_022113.1\|WP_001018965.1\|775149_775536_+\|topiosmerase	gnl\|CDD\|224572	COG1658, COG1658, Small primase-like proteins (Toprim domain) [DNA replication, recombination, and repair].	1.24029e-35
NC_022113.1\|WP_000974455.1\|770087_770510_-\|organic-hydroperoxide-resistance-protein	gnl\|CDD\|274649	TIGR03561, organ_hyd_perox, peroxiredoxin, Ohr subfamily. pfam02566, OsmC-like protein, contains several deeply split clades of homologous proteins. The clade modeled here includes the protein Ohr, or organic hydroperoxide resistance protein. [Cellular processes, Detoxification].	1.40241e-61
NC_022113.1\|WP_025173845.1\|780003_781392_-\|SAP-domain-containing-protein	gnl\|CDD\|366887	pfam02037, SAP, SAP domain. The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.	1.45613e-08
NC_022113.1\|WP_001661454.1\|781418_781991_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	2.25772e-06
NC_022113.1\|WP_000270271.1\|778769_779990_-\|site-specific-integrase	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	3.69807e-37
NC_022113.1\|WP_000124597.1\|782384_782657_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379251	pfam13545, HTH_Crp_2, Crp-like helix-turn-helix domain. This family represents a crp-like helix-turn-helix domain that is likely to bind DNA.	0.00479643
NC_022113.1\|WP_001140696.1\|767767_768349_+\|histidine-phosphatase-family-protein	gnl\|CDD\|223483	COG0406, phoE, Broad specificity phosphatase PhoE and related phosphatases [General function prediction only].	1.48716e-48
NC_022113.1\|WP_000422908.1\|771456_771996_+\|nitroreductase	gnl\|CDD\|380312	cd02135, YdjA-like, nitroreductase family protein similar to Escherichia coli YdjA. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase YdjA from Escherichia coli. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.	2.10032e-49
NC_022113.1\|WP_001794224.1\|773681_774560_+\|DUF1963-domain-containing-protein	gnl\|CDD\|226395	COG3878, COG3878, Uncharacterized protein conserved in bacteria [Function unknown].	1.37279e-75
NC_022113.1\|WP_000569884.1\|769194_769689_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|372596	pfam13420, Acetyltransf_4, Acetyltransferase (GNAT) domain.	2.53639e-47

>NC_022113.1|WP_001794224.1|773681_774560_+|DUF1963-domain-containing-protein
MVNIQDVSHLSKKEQKAYNRFVESVENGNLPVLPCIEMDLKEMQEETLNQSKIGGMPFLKSFKDIPLDENNVPMVLLAQINLNDLPEQQELFPVNEGILQFWISSEDQMYGMSENLKGNNINSRLVYIKEPITDLSLKDIQAHLKSLDADNEDIPFSGAFSIEFRLSKQTITCTDYKYDEDDLALWNKVNPSFALKSMFGGYDELMEPVCNTFTAKEPFNQLGGYPYFDQIDPRTNDQELKMYDRVLLQIDSTRDGNSSIIWGDLGIANILVKSTDLEAMKFDDYMYSWDCS
>NC_022113.1|WP_000290491.1|773123_773504_+|glycine-cleavage-system-protein-GcvH
MAVPNELKYSKEHEWVKVEGNVATIGITEYAQSELGDIVFVELPETDDEINEGDTFGSVESVKTVSELYAPISGKVVEVNEELEDSPEFVNESPYEKAWMVKVEISDESQLEALLTAEKYSEMIGE
>NC_022113.1|WP_000589549.1|772609_772966_+|arsenate-reductase-family-protein
MIKFYQYKNCTTCKKAAKFLDEYGVSYEPIDIVQHTPTINEFKTIIANTGVEINKLFNTHGAKYRELDLKNKLQTLSDDEKLELLSSDGMLVKRPLAVMGDKITLGFKEDQYKETWLA
>NC_022113.1|WP_001147955.1|772145_772466_-|thioredoxin-family-protein
MQAIKSNESFKSVINSDTPVIVKFEAGWCPDCRAMDLWIDPIVEQYNDYQWYTVNRDELEDVVVENEVMGIPSLLVFKNGDKIAHLHSANAKSPEQVESFLAETFK
>NC_022113.1|WP_000422908.1|771456_771996_+|nitroreductase
MELQQAIANRRSVKKFKRDMHIDDALLYQAIEKAADAPNHGMREPWRVVHVPKDRLGDMSKDISKFAFPNELDKQQCHYDAVTKLGGMLLLILKTDPRQRQNDENYFAFGAYAQNLMLLLYEAGIGTCWKSPLYIYDPKVRKTLGIKKDEVLAGFLYLTDLEEDMPKAPRKNRNLITLY
>NC_022113.1|WP_000150025.1|770657_771374_+|type-I-3-dehydroquinate-dehydratase
MTHVEVVATIAPQLYIEETLIQKINHRIDAIDVLELRIDQIENVTVDQVAEMITKLKVMQDSFKLLVTYRTKLQGGYGQFTNDSYLNLISDLANINGIDMIDIEWQADIDIEKHQRIITHLQQYNKEVIISHHNFESTPPLDELQFIFFKMQKFNPEYVKLAVMPHNKNDVLNLLQAMSTFSDTMDCKVVGISMSKLGLISRTAQGVFGGALTYGCIGEPQAPGQIDVTDLKAQVTLY
>NC_022113.1|WP_000974455.1|770087_770510_-|organic-hydroperoxide-resistance-protein
MAIHYETKATNVGGRKGHVYTDDRALDIDIVPPAQADGKATNPEQLFAAGYASCFNGAFDLILKQNKVRDAHPEVTLTVRLEDDPDSESPKLSVSIDATIKNVISQEEAEKYLQMAHEFCPYSKATQGNINVDLNVNVVD
>NC_022113.1|WP_000569884.1|769194_769689_-|GNAT-family-N-acetyltransferase
MIEIKTLTNNDFNEYKRLVSTVNEEFTQDSHYSQTMTDTLIHDILNQGSPKCIVFGCYENETLIATAALEQIRYVGKEHKSLIKYNFVTNNDKSINSELINFIINYARQNNYESLLTSIVSNNIGAKVFYSALGFDILGFEKNAIKIGNTYFDEHWLFYDLINK
>NC_022113.1|WP_000255542.1|768421_769039_-|amino-acid-transporter
MVTAIIHGFILAIGLILPLGAQNVFIFNQGANQPKYRYVLLAIITAGLSDSLLIIIAVVGVSIIIMSLPILQAIIYIVGLIFLMYMAWTIWHDKPSTDGEAQIMSPMKQVSFALSVSLLNPHAILDTIGVIGSSAALYSGSNKIAFTIACISVSWLWFFLLAILGKMVGSIDKTGKLLTIINKISSIIIIIVALMILQKLIQLLF
>NC_022113.1|WP_001140696.1|767767_768349_+|histidine-phosphatase-family-protein
MAKTLYLMRHGQTLFNFKGLIQGFGDSPLTELGIAQAQKARSYYETKGINFDLYASSTQERASDTLENVAPNQSYQRFKGLKEWHFGLFEGESVYLFDNLYKPEDLFGDRIVPFKGEARQQVEDRIVKTLHDIMSQTKNNALVVSHGTIMGVFLRYCLKLDEALKHNIGNCNILKFEYDNGTFKFVELIDPNL
>NC_022113.1|WP_001018965.1|775149_775536_+|topiosmerase
MAIVNKVIIVEGKSDKKRVQQVIAEPVNIICTHGTMSIDKLDDMIESLYDKQVFVLADSNDEGDRIRNWFKRYLSESEHIFIDKTYCQVANCPKQYLAHVLSKHGFTCKKETPFLPNINNERLVLVNE
>NC_022113.1|WP_001065804.1|775528_775825_+|thioredoxin-family-protein
MNNSLDIKDVTTFYEEDKHLIYGYTPTCGTCKVSERMLDITNEILQLPLLKIDLNFYPQFCKDMQIMSTPILLLMNKDKEVKRIYAFQSVTDLLENLK
>NC_022113.1|WP_000571222.1|776074_777100_+|methionine-ABC-transporter-ATP-binding-protein
MIELKEVVKEYRTKNKEVLAVDHVNLSIRAGSIYGVIGFSGAGKSTLIRMFNHLEAPTSGEVIIDGDHIGRLSKNGLRAKRQKVSMIFQHFNLLWSRTVLKNIMFPLEIAGVPRRRAKQKALELVELVGLKGREKAYPSELSGGQKQRVGIARALANDPTVLLCDEATSALDPQTTDEILDLLLKIREQQNLTIILITHEMHVIRRICDEVAVMESGKVIEHGPVTQVFENPQHAVTKRFVKEDLNDDFETSLTELEPLEKDAYIVRLVFAGSTTTEPIVSSLSTAYDIKINILEANIKNTKNGTVGFLVLHIPYISSIDFGKFEKELIERQVKMEVLRHG
>NC_022113.1|WP_000520233.1|777092_777788_+|ABC-transporter-permease
MGKSFSEIINEMITMPNIQWPEVWTAIVETLYMTVVSTIFAFILGLILGVLLFLSAKGKSIGARLFYSIVSFIVNLFRAIPFIILILLLIPFTSLILGTISGPTGALPALIIGAAPFYARLVEIAFKEIDKGVIEAAWSMGANTWTVIRKVLLPEAMPALVSGITVTAIALVGSTAVAGVIGAGGLGNLAYLTGFTRNQNDVILVSTVFILIIVFIIQFIGDWLTNKLDKR
>NC_022113.1|WP_000732338.1|777805_778627_+|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein
MKKLFGLILVLTFAVVLAACGNGSKSGSDDKKITVGASPAPHAEILEKAKPLLEKKGYELDIKTINDYTTPNKLLDKGEIDANYFQHTPYLNTEKKDKGYKIVSAGNVHLEPMAVYSKKYKSLKELPKGATVYVSNNPAEQGRFLKFFVDAGLIKIKKGVKIEDAKFSDITENKKDIKFNNKQSAEFLPKIYQNEDADAVIINSNFAIEQKLNPKKDSIAVESAKDNPYANLIAVKEGHQDDKKIKALIEVLQSKDIQDFINEKYNGAVIPAK
>NC_022113.1|WP_000270271.1|778769_779990_-|site-specific-integrase
MWYEKFTNKHGETKYRYYEKYKDPLTNKWRRVSVVLNKNGKQSQKEAQRRLNERIEAKLNDNTPTTLKSLTFHVACDEWFQNYIKTSGSKRTTIKTKLSKLNTLKKFVDEDILINKITLSYAQQVFDEMDSKGYVYQVNKDALSIFKNVFEYTRRIYKLQDLEFLKDITLNKRIKSYDEVKAKRNKYLELNEIQSIIKDINMKAQKMHSGIHKRFYLFVALMTEFQALNGMRIGEMLAIKNEDIDFDNKSLNINGTIHWFHDESGGFGVKDTTKTESSYRTIGLSSRSCEILKKAILENKKDSKWNDGYLNRNFVFTNHKGNPMQTERFNKILRESAKDVGIEKEISSHILRHSHISLLSQQGVSLKAIMDRVGHSDHRTTLSIYSHVTEQMDKDMMNKLEQVKLG
>NC_022113.1|WP_025173845.1|780003_781392_-|SAP-domain-containing-protein
MKKIFYCFLLIFSILMLFGGINEVTQNKLTFIDIFMFAIFISLIVFSIVKLFKHNHLDYKSNKSNTNHKNISNSKTTQFNTVQSNDHIRKNNITHDIETNNTKKVKQVKSITNNKTNTLNKDQVKLNENVQENNQDLVIDVKDDNNNNYHYDLNANDILILHLNKNREVGKEVKNHFYLLENQINVDEILNKLINLNYLDIKSNFDVSLFYLKVPELKEILREYKLKLSGNKPELIERIKTNIDENAIKLPQVYVPTSKGNKIIGETEYILHFYNSPIISLGSAHKMAKEVLNIDDKIEYIYFYLLQQNQKSNNSDHRTANIINSLVLYYKKTNKDKDVIRKYTNYATYLSVTQGIHSAAFLYSSEENIIDRLFIYFNYHLEYYENMLFIDNVSRRLFKNLFYEDIKSFEDTDKNFCDEICELLFAQIYNNRNITLNNLPTINYVLEKIKKENEIRMTKYDF
>NC_022113.1|WP_001661454.1|781418_781991_-|helix-turn-helix-transcriptional-regulator
MQQNSLEDFSNILKNFRKAEDLTLDTLSKYLGVSDVYVSKLENGKRFPSKNILFWYVLFMDQSQMHDDIEKLLTIFSENKKISYEQLRTEYDEFVKKFREKQKKHSSKIQRKEIKLTMNEFNQYQIEEIDEPYFDLKWLLNQSEYKLFYSGIDNKNSLGFNEVLSESDKKMLSEIVNSVIQRIYNDENQK
>NC_022113.1|WP_000560872.1|782162_782384_+|helix-turn-helix-transcriptional-regulator
MIAKVNYLKRLIAFEGLSLKDFASEIEVNSNFLNSIVNGKRTTSPKTANKIAKRLNVDIKDIFIFIEEKEEVK
>NC_022113.1|WP_000124597.1|782384_782657_+|helix-turn-helix-domain-containing-protein
MARTKLKDIPTKENTISEPKQVVVKPLFAKPNALASIFGISYSSTNRILKEWEKDPKGVDDLYYSLSSTMTVISIPRFEEYMKKRHKKWM

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Crispr_ID: NC_022113_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022113_5

840149-840234

Orphan

Consensus_repeat	Method
AAAGTCAGCTTACAATAATGTGCAAGTTGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022113_5

>merge|NC_022113|5|840149-840234|CRISPRCasFinder
AAAGTCAGCTTACAATAATGTGCAAGTTGGCGGGGCCCCAACACAGAAGCTGGTGGAAAGCCAGCTTACAATAATGTGCAAGTTGG

>NC_022113|5|5|840149-840234|CRISPRCasFinder
AAAGTCAGCTTACAATAATGTGCAAGTTGG	CGGGGCCCCAACACAGAAGCTGGTGG
AAAGCCAGCTTACAATAATGTGCAAGTTGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_022113.1\|WP_000138487.1\|838753_839998_+\|Glu/Leu/Phe/Val-dehydrogenase	unknown	unknown	gnl\|CDD\|223411
NC_022113.1\|WP_000573086.1\|829038_830535_-\|Na+/H+-antiporter-Mnh1-subunit-D	unknown	unknown	gnl\|CDD\|181085
NC_022113.1\|WP_000781162.1\|833825_834209_-\|kinase-associated-lipoprotein-B	unknown	unknown	gnl\|CDD\|378054
NC_022113.1\|WP_000670755.1\|855296_856199_+\|fumarylacetoacetate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|223257
NC_022113.1\|WP_000167322.1\|837454_838645_+\|ornithine--oxo-acid-transaminase	unknown	unknown	gnl\|CDD\|179736
NC_022113.1\|WP_000185311.1\|840392_841322_-\|glycerophosphodiester-phosphodiesterase	unknown	unknown	gnl\|CDD\|176543
NC_022113.1\|WP_000154951.1\|851477_855131_+\|helicase-exonuclease-AddAB-subunit-AddA	unknown	unknown	gnl\|CDD\|274299
NC_022113.1\|WP_001081626.1\|830868_831297_-\|Na+/H+-antiporter-Mnh1-subunit-B	unknown	unknown	gnl\|CDD\|183602
NC_022113.1\|WP_000402803.1\|830527_830869_-\|Na+/H+-antiporter-Mnh1-subunit-C	unknown	unknown	gnl\|CDD\|181497
NC_022113.1\|WP_000172367.1\|848000_851477_+\|helicase-exonuclease-AddAB-subunit-AddB	unknown	unknown	gnl\|CDD\|213736
NC_022113.1\|WP_001067294.1\|835280_835658_+\|S1-RNA-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|224023
NC_022113.1\|WP_000758209.1\|846725_847250_+\|signal-peptidase-I	unknown	unknown	gnl\|CDD\|274044
NC_022113.1\|WP_000838046.1\|836019_837147_+\|NADH-dependent-flavin-oxidoreductase	unknown	unknown	gnl\|CDD\|240086
NC_022113.1\|WP_000035058.1\|834272_834866_+\|peptidylprolyl-isomerase	unknown	unknown	gnl\|CDD\|238908
NC_022113.1\|WP_000054599.1\|831289_833695_-\|Na+/H+-antiporter-Mnh1-subunit-A	unknown	unknown	gnl\|CDD\|237155
NC_022113.1\|WP_000711897.1\|847265_847841_+\|signal-peptidase-I	unknown	unknown	gnl\|CDD\|274044
NC_022113.1\|WP_000148855.1\|844488_845820_+\|glucose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|184504
NC_022113.1\|WP_000007960.1\|846145_846721_+\|TVP38/TMEM64-family-protein	unknown	unknown	gnl\|CDD\|223475
NC_022113.1\|WP_000066056.1\|841563_842943_-\|argininosuccinate-lyase	unknown	unknown	gnl\|CDD\|179143
NC_022113.1\|WP_000660054.1\|842932_844138_-\|argininosuccinate-synthase	unknown	unknown	gnl\|CDD\|234785

Protein	Function_ID	Function_description	E-value
NC_022113.1\|WP_000138487.1\|838753_839998_+\|Glu/Leu/Phe/Val-dehydrogenase	gnl\|CDD\|223411	COG0334, GdhA, Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism].	0
NC_022113.1\|WP_000573086.1\|829038_830535_-\|Na+/H+-antiporter-Mnh1-subunit-D	gnl\|CDD\|181085	PRK07691, PRK07691, putative monovalent cation/H+ antiporter subunit D; Reviewed.	0
NC_022113.1\|WP_000781162.1\|833825_834209_-\|kinase-associated-lipoprotein-B	gnl\|CDD\|378054	pfam08810, KapB, Kinase associated protein B. This bacterial protein forms an anti-parallel beta sheet with an extending alpha helical region.	8.96507e-53
NC_022113.1\|WP_000670755.1\|855296_856199_+\|fumarylacetoacetate-hydrolase-family-protein	gnl\|CDD\|223257	COG0179, MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism].	1.74159e-87
NC_022113.1\|WP_000167322.1\|837454_838645_+\|ornithine--oxo-acid-transaminase	gnl\|CDD\|179736	PRK04073, rocD, ornithine--oxo-acid transaminase; Provisional.	0
NC_022113.1\|WP_000185311.1\|840392_841322_-\|glycerophosphodiester-phosphodiesterase	gnl\|CDD\|176543	cd08601, GDPD_SaGlpQ_like, Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins. This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in uncharacterized glycerophosphodiester phosphodiesterase (GP-GDE, EC 3.1.4.46) from Staphylococcus aureus, Bacillus subtilis and similar proteins. Members in this family show very high sequence similarity to Escherichia coli periplasmic phosphodiesterase GlpQ, which catalyzes the Ca2+-dependent degradation of periplasmic glycerophosphodiesters to produce sn-glycerol-3-phosphate (G3P) and the corresponding alcohols.	8.83368e-151
NC_022113.1\|WP_000154951.1\|851477_855131_+\|helicase-exonuclease-AddAB-subunit-AddA	gnl\|CDD\|274299	TIGR02785, ATP-dependent_helicase/nuclease_subunit_A, helicase-exonuclease AddAB, AddA subunit, Firmicutes type. AddAB, also called RexAB, substitutes for RecBCD in several bacterial lineages. These DNA recombination proteins act before synapse and are particularly important for DNA repair of double-stranded breaks by homologous recombination. The term AddAB is used broadly, with AddA homologous between the Firmicutes (as modeled here) and the alphaproteobacteria, while the partner AddB proteins show no strong homology across the two groups of species. [DNA metabolism, DNA replication, recombination, and repair].	0
NC_022113.1\|WP_001081626.1\|830868_831297_-\|Na+/H+-antiporter-Mnh1-subunit-B	gnl\|CDD\|183602	PRK12573, PRK12573, Na(+)/H(+) antiporter subunit B.	9.17513e-61
NC_022113.1\|WP_000402803.1\|830527_830869_-\|Na+/H+-antiporter-Mnh1-subunit-C	gnl\|CDD\|181497	PRK08600, PRK08600, putative monovalent cation/H+ antiporter subunit C; Reviewed.	9.82501e-64
NC_022113.1\|WP_000172367.1\|848000_851477_+\|helicase-exonuclease-AddAB-subunit-AddB	gnl\|CDD\|213736	TIGR02773, ATP-dependent_helicase/deoxyribonuclease_subunit_B, helicase-exonuclease AddAB, AddB subunit. DNA repair is accomplished by several different systems in prokaryotes. Recombinational repair of double-stranded DNA breaks involves the RecBCD pathway in some lineages, and AddAB (also called RexAB) in other. The AddA protein is conserved between the firmicutes and the alphaproteobacteria, while the partner protein is not. Nevertheless, the partner is designated AddB in both systems. This model describes the AddB protein as found Bacillus subtilis and related species. Although the RexB protein of Streptococcus and Lactococcus is considered to be orthologous, functionally equivalent, and merely named differently, all members of this protein family have a P-loop nucleotide binding motif GxxGxGK[ST] at the N-terminus, unlike RexB proteins, and a CxxCxxxxxC motif at the C-terminus, both of which may be relevant to function. [DNA metabolism, DNA replication, recombination, and repair].	0
NC_022113.1\|WP_001067294.1\|835280_835658_+\|S1-RNA-binding-domain-containing-protein	gnl\|CDD\|224023	COG1098, VacB, Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis].	3.22125e-44
NC_022113.1\|WP_000758209.1\|846725_847250_+\|signal-peptidase-I	gnl\|CDD\|274044	TIGR02227, Inactive_signal_peptidase_IA., signal peptidase I, bacterial type. This model represents signal peptidase I from most bacteria. Eukaryotic sequences are likely organellar. Several bacteria have multiple paralogs, but these represent isozymes of signal peptidase I. Virtually all known bacteria may be presumed to A related model finds a simlar protein in many archaea and a few bacteria, as well as a microsomal (endoplasmic reticulum) protein in eukaryotes. [Protein fate, Protein and peptide secretion and trafficking].	1.81012e-49
NC_022113.1\|WP_000838046.1\|836019_837147_+\|NADH-dependent-flavin-oxidoreductase	gnl\|CDD\|240086	cd04735, OYE_like_4_FMN, Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as electron acceptors in the catalytic reaction. Other members of OYE family include trimethylamine dehydrogenase, 2,4-dienoyl-CoA reductase, enoate reductase, pentaerythriol tetranitrate reductase, xenobiotic reductase, and morphinone reductase.	0
NC_022113.1\|WP_000035058.1\|834272_834866_+\|peptidylprolyl-isomerase	gnl\|CDD\|238908	cd01927, cyclophilin_WD40, cyclophilin_WD40: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a WD40 domain. This group consists of several hypothetical and putative eukaryotic and bacterial proteins which have a cyclophilin domain and a WD40 domain. Function of the protein is not known.	3.93388e-65
NC_022113.1\|WP_000054599.1\|831289_833695_-\|Na+/H+-antiporter-Mnh1-subunit-A	gnl\|CDD\|237155	PRK12645, PRK12645, monovalent cation/H+ antiporter subunit A; Reviewed.	0
NC_022113.1\|WP_000711897.1\|847265_847841_+\|signal-peptidase-I	gnl\|CDD\|274044	TIGR02227, Inactive_signal_peptidase_IA., signal peptidase I, bacterial type. This model represents signal peptidase I from most bacteria. Eukaryotic sequences are likely organellar. Several bacteria have multiple paralogs, but these represent isozymes of signal peptidase I. Virtually all known bacteria may be presumed to A related model finds a simlar protein in many archaea and a few bacteria, as well as a microsomal (endoplasmic reticulum) protein in eukaryotes. [Protein fate, Protein and peptide secretion and trafficking].	1.63465e-53
NC_022113.1\|WP_000148855.1\|844488_845820_+\|glucose-6-phosphate-isomerase	gnl\|CDD\|184504	PRK14097, pgi, glucose-6-phosphate isomerase; Provisional.	0
NC_022113.1\|WP_000007960.1\|846145_846721_+\|TVP38/TMEM64-family-protein	gnl\|CDD\|223475	COG0398, COG0398, Uncharacterized conserved protein [Function unknown].	4.0006e-40
NC_022113.1\|WP_000066056.1\|841563_842943_-\|argininosuccinate-lyase	gnl\|CDD\|179143	PRK00855, PRK00855, argininosuccinate lyase; Provisional.	0
NC_022113.1\|WP_000660054.1\|842932_844138_-\|argininosuccinate-synthase	gnl\|CDD\|234785	PRK00509, PRK00509, argininosuccinate synthase; Provisional.	0

>NC_022113.1|WP_000138487.1|838753_839998_+|Glu/Leu/Phe/Val-dehydrogenase
MTENNNLVTSTQGIIKEALHKLGFDEGMYDLIKEPLRMLQVRIPVRMDDGTVKTFTGYRAQHNDAVGPTKGGVRFHPDVDEEEVKALSMWMTLKCGIVNLPYGGGKGGIVCDPRQMSIHEVERLSRGYVRAISQFVGPNKDIPAPDVFTNSQIMAWMMDEYSALDKFNSPGFITGKPIVLGGSHGRDRSTALGVVIAIEQAAKRRNMQIEGAKVVIQGFGNAGSFLAKFLYDLGAKIVGISDAYGALHDPNGLDIDYLLDRRDSFGTVTNLFEETISNKELFELDCDILVPAAISNQITEDNAHDIKASIVVEAANGPTTPEATRILTERGILLVPDVLASAGGVTVSYFEWVQNNQGYYWSEEEVNEKLREKLEAAFDTIYELSQNRKIDMRLAAYIIGIKRTAEAARYRGWA
>NC_022113.1|WP_000167322.1|837454_838645_+|ornithine--oxo-acid-transaminase
MTKSEKIIELTNHYGAHNYLPLPIVISEAEGVWVKDPEGNKYMDMLSAYSAVNQGHRHPKIIQALKDQADKVTLVSRAFHSDNLGEWYEKICKLAGKDKALPMNTGAEAVETALKAARRWAYDVKGIEPNKAEIIAFNGNFHGRTMAPVSLSSEAEYQRGYGPLLDGFRKVDFGDVDALKAAINKNTAAVLVEPIQGEAGINIPPEGYLKAIRELCDEHNVLFIADEIQAGLGRSGKLFATDWDNVKPDVYILGKALGGGVFPISVVLADKEVLDVFTPGSHGSTFGGNPLACAASIAALDVIVDEDLPGRSLELGDYFKEQLKQIDHPSIKEVRGRGLFIGVELNESARPYCEALKEEGLLCKETHDTVIRFAPPLIITKEELDLALEKIRHVFQ
>NC_022113.1|WP_000838046.1|836019_837147_+|NADH-dependent-flavin-oxidoreductase
MKSKYEPLFDKVVLPNGVELRNRFVLAPLTHISSNDDGTISDIELPYIEKRSQDVGITSNAASNVSDVGKAFPGQPSIAHDSDIEGLKRLATAMKKNGAKALVQIHHGGAQALPELTPDGDVVAPSPISLKSFGQKQEHSAREMTNEEIEQAIKDFGEATRRAIEAGFDGVEIHGANHYLIHQFVSPYYNRRNDVWANQYKFPIAVIEEVLKAKEVYGNKDFIVGYRLSPEEAESPGITMEITEELVNKISHMPIDYIHVSMMDTHATAREGKYAGQERLPLIHKWINGRMPLIGIGSIFTADDALDAVENVGVDLVAIGRELLLDYQFVEKIKDGREDEIINYFDPEREDNHHLTPNLWHQFNEGFYPLPRKDK
>NC_022113.1|WP_001067294.1|835280_835658_+|S1-RNA-binding-domain-containing-protein
MNNYKIGQHIKVRVTGIQPYGAFVETPNHTEGLIHISEIMDDYVHNLKKFLSEGQIVKAKILSIDDEGKLNLSLKDNDYFKNYERKKEKQSVLDEIRETEKYGFQTLKERLPIWIKQSKRAIRND
>NC_022113.1|WP_000035058.1|834272_834866_+|peptidylprolyl-isomerase
MANYPQLNKEVQQGEIKVVMHTNKGDMTFKLFPNIAPKTVENFVTHAKNGYYDGITFHRVINDFMIQGGDPTATGMGGESIYGGAFEDEFSLNAFNLYGALSMANSGPNTNGSQFFIVQMKEVPQNMLSQLADGGWPQPIVDAYGEKGGTPWLDQKHTVFGQIIDGETTLEDIANTKVGPQDKPLHDVVIESIDVEE
>NC_022113.1|WP_000781162.1|833825_834209_-|kinase-associated-lipoprotein-B
MKLYRFSHKTGSYGVTIVEENGDDVLVKVEQVIKHPKQGDLHNPTETEGVFFHERKALSHFEKRYTKRSQLRDFNVDVLRYEDSLQQAITDLETKLKAQQTKHAEMSLASLARLKEDYSLQYKENFK
>NC_022113.1|WP_000054599.1|831289_833695_-|Na+/H+-antiporter-Mnh1-subunit-A
MSLLHIAVILPLIFALIIPILYRFFKRIHLGWFVLPVPIVIFIYMLTLIKTTMSGNTVMKTLNWMPHFGMNFDLYLDGLGLLFSLLISGIGSLVVLYSIGYLSKSEQLGNFYCYLLLFMGAMLGVVLSDNVIILYLFWELTSFSSFLLISFWRERQASIYGAQKSLIITVFGGLSLLGGIILLAIPTQSFSIQYMIQHASEIQNSPFFIFAMILIMIGAFTKSAQFPFYIWLPDAMEAPTPVSAYLHSATMVKAGLYLIARMTPIFAASQGWIWTVTLVGLITLFWASLNATKQQDLKGILAFSTVSQLGMIMAMLGIGAISYHYQGDDSKIYAAAFTAAIFHLINHATFKGALFMITGAVDHSTGTRDVKKLGGLLTIMPISFTITVITALSMAGVPPFNGFLSKESFLETTFTASKANLFSVDTLGYLFPIIGIVGSVFTFVYSIKFIMHIFFGQYKPEQLPKKAHEVSILMLLSPAILATLVIVFGLFPGILTNSIIEPATSSINHTVIDDVEFHMFHGLTPAFLSTLVIYILGILLIVTFSYWVKLLQRQPGKLTFNYWYNRSANVIPNYSEKMTNSYVTDYSRNNLVIIFGALILLTFVTVFSVPFNINFKDVSPIRIFEVCIVILLLSAAFLILFAKSRLFSIIMLSAVGYAVSVLFIFFKAPDLALTQFVVESISTALFLLCFYHLPNLNRYNEKRSFQLTNALIAGGVGLSVIIIGLIAYGNRHFESISKFYQEHVYDLAHGKNMVNVILVDFRGMDTLFESSVLGIAGLAVYTMIKLRKKRQTQGNEVKNHE
>NC_022113.1|WP_001081626.1|830868_831297_-|Na+/H+-antiporter-Mnh1-subunit-B
MNRQQNDLILQFAAVIIFFMVMVFGFSLFLAGHYTPGGGFVGGLLFASSLVIITIAFDIETMRKIFPLDFKILIGIGLVFCIATPIASWFLGKNFFTHVTFDIPLFILEPVHMTTAVFFDFGVLCAVVGTVMTIIISIGENE
>NC_022113.1|WP_000402803.1|830527_830869_-|Na+/H+-antiporter-Mnh1-subunit-C
MEIIMIFVSGILTAISVYLVLSKSLIRIVMGTTLLTHAANLFLITMGGLKHGTVPIYEANVKSYVDPIPQALILTAIVIAFATTAFFLVLAFRTYKELGTDNVESMKGVPEDD
>NC_022113.1|WP_000573086.1|829038_830535_-|Na+/H+-antiporter-Mnh1-subunit-D
MIESNMLVLTLVIPVITAILLVFIGKRPIIKRYVALGGTLLTLVAAIINLANVVKHGPLRVELGSWKAPYSIVFVLDIFSALLIITSIIITAIVILYSYQTIGIERERYYYYFSVLFMLIGIIGAFTTGDIFNLFVFFEVFLMSSYFLLVIGSTKIQLQETIKYVLVNVVSSSFFVMGVAILYSVVGTLNLADISNKLANLSAHDSGLVNIVFILFIFVFATKAGVFPMFVWLPSAYYAPPIPIIAFFGALLTKVGVYAIARTLSLFFSDNVSFSHYVILFLALLTIIFGCVGAVAYANIKKIILYNVMIAVGVILVGVAMMTESGMIGAIYYTLHDMLVKLALFLLIGIMIKITGTADLRQFGGLIKRYPVLGWSFFIAALSLAGIPPLSGFYGKFFIVQSTFERGFYLSGVIVLLSSLVVLYSVIRIFLQGFFGQPKGYDLNNKVDVKYLTTIAIVAVVITVLYGLSADYLYPMVKAGAETFYNPSTYVKAVLGGK
>NC_022113.1|WP_000185311.1|840392_841322_-|glycerophosphodiester-phosphodiesterase
MTNSSKSFTKFMAASAVFTMGFLSVPTAGAEQTNHIANKPQAIQWHTNLTNERFTTIAHRGASGYAPEHTFQAYDKSHNELKASYIEIDLQRTKDGHLVAMHDENVNRTTNGHGKVEDYTLDELKQLDAGSWFNKKYPKYARASYKNAKVPTLDEILERYGPNANYYIETKSPDVYPGMEEQLLASLKKHHLLNKNKLKNGHVMIQSFSDESLKKIHRQNKHVPLVKLVDKGELQQFNDQRLKEIRSYAIGLGPDYTDLTEQNTHHLKDLGFIVHPYTVNEKADMLRLNKYGVDGVFTNFADKYKEVIK
>NC_022113.1|WP_000066056.1|841563_842943_-|argininosuccinate-lyase
MSNKAWGGRFEVQPEEWVDDFNASITFDQTLIDQDIEGSIAHATMLANQGIISQQDSEQIIQGLKSIQHDYHQDQIQFSASLEDIHLNIEHELIKRIGDAGGKLHTGRSRNDQVATDMHLYTKKQVQDIIALIKSLQSVIVDIASNNVDTIMPGYTHLQRAQPISFAHHIMTYFWMLQRDQQRFEDSLKRIDINPLGAAALSGTTYPIDRHETTALLNFGSLYENSLDAVSDRDYIIETLHNISLTMVHLSRFAEEIIFWSTDEAKFITLSDAFSTGSSIMPQKKNPDMAELIRGKVGRTTGHLMSMLMTLKGLPLAYNKDMQEDKEGLFDAVHTIKGSLRIFEGMIQTMTINKERLNQTVKEDFSNATELADYLVTKNIPFRTAHEIVGKIVLECIQQGHYLLDVPLSTYQQHHSSIDADIYDYLQPENCLKRRQSYGSTGQSSVKQQLDVAKQLLSQ
>NC_022113.1|WP_000660054.1|842932_844138_-|argininosuccinate-synthase
MKEKIVLAYSGGLDTSVAVQWLIDKGYDVVACCLDVGEGKDLDIVYKKALDMRAVECHIIDATKEFSDEYVSYAIKGNLMYENAYPLVSALSRPLIAKKLVEIAEKTNSVGIAHGCTGKGNDQVRFEVAIKALNPSLKAFAPVREWAWSREEEIDYAIKHNIPVSINHDSPYSIDQNLWGRANECGILEDPYAAPPEDAFDLTNALEETPDTADEIILTFDKGIPVQIDGKTYELDDLILTLNALAGKHGIGRIDHVENRLVGIKSREIYEAPAAEVILKAHKALETITLTKDVAHFKPIIEKQFAEQLYNGLWFSPLTDSLKLFIDSTQQYVSGDVRIKLFKGNAIVNGRKSPYTLYDEKLATYTKEDAFNQDAAVGFIDIYGLPTQVNAMLHGGYSNEQ
>NC_022113.1|WP_000148855.1|844488_845820_+|glucose-6-phosphate-isomerase
MTHIQLDFSKTLEFFGEHELKQQQEIVKSIHKTIHEGTGAGSDFLGWVDLPVDYDKEEFSRIVEASKRIKENSDVLVVIGIGGSYLGARAAIEMLTSSFRNSNEYPEIVFVGNHLSSTYTKELVDYLADKDFSVNVISKSGTTTEPAVAFRLFKQLVEERYGKEEAQKRIFATTDKEKGALKQLATNEGYETFIVPDDVGGRYSVLTAVGLLPIATAGINIEAMMIGAAKAREELSSDKLEENIAYQYATIRNILYAKGYTTEMLINYEPSMQYFNEWWKQLFGESEGKDFKGIYPSSANYTTDLHSLGQYVQEGRRFLFETVVKVNHPKYDITIEKDSDDLDGLNYLAGKTIDEVNTKAFEGTLLAHTDGGVPNMVVNIPQLDEETFGYVVYFFELACAMSGYQLGVNPFNQPGVEAYKQNMFALLGKPGFEDLKKELEERL
>NC_022113.1|WP_000007960.1|846145_846721_+|TVP38/TMEM64-family-protein
MSFHQVEEWFEIFRQFGYLPGFILLYIRAIIPVFPLALYILINIQAYGPILGILISWLGLISGTFTVYLICKRLVDTERMQRIKQRTAVQRLISFIDRQGLIPLFILLCFPFTPNTLINFVASLSHIRPKYYFIVLASSKLVSTIILGYLGKEITTILTHPLRGILMLVVLIVFWIVGKKLEQHFMGSKKE
>NC_022113.1|WP_000758209.1|846725_847250_+|signal-peptidase-I
MKKVVKYLISLILAIIIVLFVQTFVIVGHVIPNNDMSPTLNKGDRVIVNKIKVTFNQLNNGDIITYRRGNEIYTSRIIAKPGQSMAFRQGQLYRDDRPVDASYAKNRKIKDFSLRNFKELDGDIIPPNNFVVLNDHDNNQHDSRQFGLIDKKDIIGNISLRYYPFSKWTIQFKS
>NC_022113.1|WP_000711897.1|847265_847841_+|signal-peptidase-I
MKKELLEWIISIAVAFVILFIVGKFIVTPYTIKGESMDPTLKDGERVAVNIIGYKTGGLEKGNVVVFHANKNDDYVKRVIGVPGDKVEYKNDTLYVNGKKQDEPYLNYNLKHKQGDYITGTFQVKDLPNANPKSNVIPKGKYLVLGDNREVSKDSRAFGLIDEDQIVGKVSFRFWPFSEFKYNFNPENTKN
>NC_022113.1|WP_000172367.1|848000_851477_+|helicase-exonuclease-AddAB-subunit-AddB
MTLHAYLGRAGTGKSTKMLTEIKQKMKADPLGDPIILIAPTQSTFQLEQAFVNDPELNGSLRTEVLHFERLSHRIFQEVGSYSEQKLSKAATEMMIYNIVQEQQKYLKLYQSQAKYYGFSEKLTEQIQDFKKYAVTPEHLESFIADKNMQTRTKNKLEDIALIYREFEQRIQNEFITGEDALQYFIDCMPKSEWLKRADIYIDGFHNFSTIEYLIIKGLIKYAKSVTIILTTDGNHDQFSLFRKPSEVLRHIEEISNELNISIERQYFNQLYRFNNQDLKHLEQEFDALQINRVACQGHINILESATMREEINEIARRIIVDIRDKQLRYQDIAILYRDESYAYLFDSILPLYNIPYNIDTKRSMTHHPVMEMIRSLIEVIQSNWQINPMLRLLKTDVLTTSYLKSAYLVDLLENFVLERGIYGKRWLDDELFNVEHFSKMGRKAHKLTEDERNTFEQVVKLKKDVIDKILHFEKQMSQAATVKDFATAFYESMEYFELPNQLMTERDELDLNGNHEKAEEIDQIWNGLIQILDDLVLVFGDEPMSMERFLEVFDIGLEQLEFVMIPQTLDQVSIGTMDLAKVDNKQHVYLVGMNDGTMPQPVTASSLITDEEKKYFEQQANVELSPTSDILQMDEAFVCYVAMTRAKGNVTFSYSLMGSSGDDKEISPFLNQIQSLFNQLEITNIPQYHEVNPLSLMQHAKQTKITLFEALRAWLDDEIVADSWLDAYQVIRDSDHLSQGLDYLMSALTFDNETVKLGETLSKDLYGKEINASVSRFEGYQQCPFKHYASHGLKLNERTKYELQNFDLGDIFHSVLKYISERINGDFKQLDLKKIRQLTNEALEEILPKVQFNLLNSSAYYRYLSRRIGAIVETTLSALKYQGTYSKFMPKHFETSFRRKPRTNDELIAQTLTTTQGIPINIRGQIDRIDTYTKNDTSFVNIIDYKSSEGSATLDLTKVYYGMQMQMMTYMDIVLQNKQRLGLTDIVKPGGLLYFHVHEPRIKFKSWADIDEDKLEQDLIKKFKLSGLVNADQTVIDALDIRLEPKFTSDIVPVGLNKDGSLSKRGSQVADEATIYKFIQHNKENFIETASNIMDGHTEVAPLKYKQKLPCAFCSYQSVCHVDGMIDSKRYRTVDETINPIEAIQNININDEFGGEQ
>NC_022113.1|WP_000154951.1|851477_855131_+|helicase-exonuclease-AddAB-subunit-AddA
MTIPEKPQGVIWTDAQWQSIYETGQDVLVAAAAGSGKTAVLVERIIQKILRDGIDVDRLLVVTFTNLSAREMKHRVDQRIQEASIADPANAHLKNQRIKIHQAQISTLHSFCLKLIQQHYDVLNIDPNFRTSSEAENILLLEQTIDEVIEQHYDILDPAFIELTEQLSSDRSDDQFRMIIKQLYFFSVANPNPTNWLDQLVTPYEEEAQQAQLIQLLTDLSKVFITAAYDALNKAYDLFSMMDGVDKHLAVIEDERRLMGRVLEGGFIDISYLTGHEFGARLPNVTAKIKEANEMMVDALEDAKLQYKKYKSLIDKVKSDYFSREADDLKADMQQLAPRVKYLARIVKDVMSEFNRKKRSKNILDFSDYEHFTLQILTNEDGSPSEIAESYRQHFHEILVDEYQDTNRVQEKILSCIKTGDEHNGNLFMVGDVKQSIYKFRQADPSLFIEKYQRFTLDGDGTGRRIDLSQNFRSRKEVLSTTNYIFKHMMDEQVGEVRYDEAAQLYYGAPYDESDHPVNLKVLVEADQEHSDLTGSEQEAHFIVEQVKDILEHQKVFDMKTGSYRSATYKDIVILERSFGQARNLQQAFKNEDIPFHVNSREGYFEQTEVRLVLSFLRAIDNPLQDIYLVGLMRSVIYQFKEDELAQIRILSPNDDYFYQSIVNYINDEAADAILVDKLKMFLSDIQSYQQYSKDHPVYQLIDKFYNDHYVIQYFSGLIGGRGRRANLYGLFNKAIEFENSSFRGLYQFIRFIDELIERGKDFGEENVVGPNDNVVRMMTIHSSKGLEFPFVIYSGLSKDFNKRDLKQPVILNQQFGLGMDYFDVDKEMAFPSLASVAYKAVAEKELVSEEMRLVYVALTRAKEQLYLIGRVKNDKSLLELEQLSISGEHIAVNERLTSPNPFHLIYSILSKHQSASIPDDLKFEKDIAQIEDSSRPNVNISIIYFEDVSTETILDNDEYRSVNQLETMQNGNEDVKAQIKHQLDYQYPYVNDTKKPSKQSVSELKRQYETEESGTSYERVRQYRIGFSTYERPKFLSEQGKRKANEIGTLMHTVMQHLPFKKERISEVELHQYIDGLIDKHIIEADTKKDIRMDEIMTFINSELYSIIAEAEQVYRELPFVVNQALVDQLPQGDEDVSIIQGMIDLIFVKDGVHYFVDYKTDAFNRRRGMTDEEIGTQLKNKYKIQMKYYQNTLQTILNKEVKGYLYFFKFGTLQL
>NC_022113.1|WP_000670755.1|855296_856199_+|fumarylacetoacetate-hydrolase-family-protein
MKFLSFKYNDKTSYGVKVKREDAVWDLTQVFADFAEGDFHPKTLLAGLQQNHTLDFQEQVRKAVVAAEDSGKAEDYKISFNDIEFLPPVTPPNNVIAFGRNYKDHANELNHEVERLYVFTKAASSLTGDNATIPNHKDITDQLDYEGELGIVIGKSGEKIPKALALDYVYGYTIINDITDRKAQSEQDQAFLSKSLTGGCPMGPYIVTKDELPLPENVNIVTKVNNEIRQDGNTGEMILKIDELIEEISKYVALHPGDIIATGTPAGVGAGMQPPKFLQPGDEVKVTIDNIGTLTTYIAK

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Crispr_ID: NC_022113_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022113_6

1141663-1141755

Unclear

Consensus_repeat	Method
TAAGAAACAGTAATCAATAAATTGATAACT	CRISPRCasFinder

1 spacers

cas3

The CRISPR arrays of NC_022113_6

>merge|NC_022113|6|1141663-1141755|CRISPRCasFinder
TAAGAAACAGTAATCAATAAATTGATAACTAATAAGCGGAACGCCTGAGCTAAAGCTCATGCATAAGAAACAGTAATCAATAAATTGATAACT

>NC_022113|6|6|1141663-1141755|CRISPRCasFinder
TAAGAAACAGTAATCAATAAATTGATAACT	AATAAGCGGAACGCCTGAGCTAAAGCTCATGCA
TAAGAAACAGTAATCAATAAATTGATAACT

Protein	Signature genes	Signature genes Name	Protein_function
NC_022113.1\|WP_000517908.1\|1133211_1133400_-\|50S-ribosomal-protein-L28	unknown	unknown	gnl\|CDD\|234736
NC_022113.1\|WP_000171418.1\|1133842_1134217_+\|Asp23/Gls24-family-envelope-stress-response-protein	unknown	unknown	gnl\|CDD\|224221
NC_022113.1\|WP_000426914.1\|1141844_1142078_+\|acyl-carrier-protein	unknown	unknown	gnl\|CDD\|179197
NC_022113.1\|WP_000531319.1\|1147874_1148207_+\|putative-DNA-binding-protein	unknown	unknown	gnl\|CDD\|234647
NC_022113.1\|WP_001261987.1\|1150497_1151001_+\|ribosome-maturation-factor-RimM	unknown	unknown	gnl\|CDD\|234650
NC_022113.1\|WP_000239746.1\|1138906_1139893_+\|phosphate-acyltransferase-PlsX	unknown	unknown	gnl\|CDD\|235414
NC_022113.1\|WP_001151515.1\|1136067_1138128_+\|ATP-dependent-DNA-helicase-RecG	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|236794
NC_022113.1\|WP_000268754.1\|1150034_1150310_+\|30S-ribosomal-protein-S16	unknown	unknown	gnl\|CDD\|223306
NC_022113.1\|WP_000547905.1\|1132189_1132831_+\|thiamine-diphosphokinase	unknown	unknown	gnl\|CDD\|224480
NC_022113.1\|WP_000623906.1\|1134231_1135878_+\|DAK2-domain-containing-protein	unknown	unknown	gnl\|CDD\|224378
NC_022113.1\|WP_000164332.1\|1131538_1132183_+\|ribulose-phosphate-3-epimerase	unknown	unknown	gnl\|CDD\|223114
NC_022113.1\|WP_000863477.1\|1148232_1149600_+\|signal-recognition-particle-protein	unknown	unknown	gnl\|CDD\|236780
NC_022113.1\|WP_000167269.1\|1140804_1141539_+\|3-oxoacyl-[acyl-carrier-protein]-reductase	unknown	unknown	gnl\|CDD\|235500
NC_022113.1\|WP_000262715.1\|1143071_1146638_+\|chromosome-segregation-protein-SMC	unknown	unknown	gnl\|CDD\|224117
NC_022113.1\|WP_000007673.1\|1146637_1147888_+\|signal-recognition-particle-docking-protein-FtsY	unknown	unknown	gnl\|CDD\|236686
NC_022113.1\|WP_000181404.1\|1151840_1152191_+\|50S-ribosomal-protein-L19	unknown	unknown	gnl\|CDD\|235418
NC_022113.1\|WP_000043237.1\|1142193_1142925_+\|ribonuclease-III	unknown	unknown	gnl\|CDD\|234633
NC_022113.1\|WP_000047355.1\|1139885_1140812_+\|ACP-S-malonyltransferase	unknown	unknown	gnl\|CDD\|223408
NC_022113.1\|WP_001548538.1\|1138329_1138902_+\|transcription-factor-FapR	unknown	unknown	gnl\|CDD\|179847
NC_022113.1\|WP_000687323.1\|1151000_1151738_+\|tRNA-(guanosine(37)-N1)-methyltransferase-TrmD	unknown	unknown	gnl\|CDD\|234581

Protein	Function_ID	Function_description	E-value
NC_022113.1\|WP_000517908.1\|1133211_1133400_-\|50S-ribosomal-protein-L28	gnl\|CDD\|234736	PRK00359, rpmB, 50S ribosomal protein L28; Reviewed.	1.3072e-18
NC_022113.1\|WP_000171418.1\|1133842_1134217_+\|Asp23/Gls24-family-envelope-stress-response-protein	gnl\|CDD\|224221	COG1302, COG1302, Uncharacterized protein conserved in bacteria [Function unknown].	4.1554e-37
NC_022113.1\|WP_000426914.1\|1141844_1142078_+\|acyl-carrier-protein	gnl\|CDD\|179197	PRK00982, acpP, acyl carrier protein; Provisional.	5.23888e-31
NC_022113.1\|WP_000531319.1\|1147874_1148207_+\|putative-DNA-binding-protein	gnl\|CDD\|234647	PRK00118, PRK00118, putative DNA-binding protein; Validated.	1.00966e-46
NC_022113.1\|WP_001261987.1\|1150497_1151001_+\|ribosome-maturation-factor-RimM	gnl\|CDD\|234650	PRK00122, rimM, 16S rRNA-processing protein RimM; Provisional.	1.02289e-68
NC_022113.1\|WP_000239746.1\|1138906_1139893_+\|phosphate-acyltransferase-PlsX	gnl\|CDD\|235414	PRK05331, PRK05331, phosphate acyltransferase PlsX.	7.80762e-178
NC_022113.1\|WP_001151515.1\|1136067_1138128_+\|ATP-dependent-DNA-helicase-RecG	gnl\|CDD\|236794	PRK10917, PRK10917, ATP-dependent DNA helicase RecG; Provisional.	0
NC_022113.1\|WP_000268754.1\|1150034_1150310_+\|30S-ribosomal-protein-S16	gnl\|CDD\|223306	COG0228, RpsP, Ribosomal protein S16 [Translation, ribosomal structure and biogenesis].	3.01687e-41
NC_022113.1\|WP_000547905.1\|1132189_1132831_+\|thiamine-diphosphokinase	gnl\|CDD\|224480	COG1564, THI80, Thiamine pyrophosphokinase [Coenzyme metabolism].	1.16343e-81
NC_022113.1\|WP_000623906.1\|1134231_1135878_+\|DAK2-domain-containing-protein	gnl\|CDD\|224378	COG1461, COG1461, Predicted kinase related to dihydroxyacetone kinase [General function prediction only].	0
NC_022113.1\|WP_000164332.1\|1131538_1132183_+\|ribulose-phosphate-3-epimerase	gnl\|CDD\|223114	COG0036, Rpe, Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism].	1.52718e-114
NC_022113.1\|WP_000863477.1\|1148232_1149600_+\|signal-recognition-particle-protein	gnl\|CDD\|236780	PRK10867, PRK10867, signal recognition particle protein; Provisional.	0
NC_022113.1\|WP_000167269.1\|1140804_1141539_+\|3-oxoacyl-[acyl-carrier-protein]-reductase	gnl\|CDD\|235500	PRK05557, fabG, 3-ketoacyl-(acyl-carrier-protein) reductase; Validated.	3.68137e-140
NC_022113.1\|WP_000262715.1\|1143071_1146638_+\|chromosome-segregation-protein-SMC	gnl\|CDD\|224117	COG1196, Smc, Chromosome segregation ATPases [Cell division and chromosome partitioning].	0
NC_022113.1\|WP_000007673.1\|1146637_1147888_+\|signal-recognition-particle-docking-protein-FtsY	gnl\|CDD\|236686	PRK10416, PRK10416, signal recognition particle-docking protein FtsY; Provisional.	0
NC_022113.1\|WP_000181404.1\|1151840_1152191_+\|50S-ribosomal-protein-L19	gnl\|CDD\|235418	PRK05338, rplS, 50S ribosomal protein L19; Provisional.	6.77895e-70
NC_022113.1\|WP_000043237.1\|1142193_1142925_+\|ribonuclease-III	gnl\|CDD\|234633	PRK00102, rnc, ribonuclease III; Reviewed.	4.78039e-115
NC_022113.1\|WP_000047355.1\|1139885_1140812_+\|ACP-S-malonyltransferase	gnl\|CDD\|223408	COG0331, FabD, (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism].	6.35101e-134
NC_022113.1\|WP_001548538.1\|1138329_1138902_+\|transcription-factor-FapR	gnl\|CDD\|179847	PRK04424, PRK04424, transcription factor FapR.	2.37773e-98
NC_022113.1\|WP_000687323.1\|1151000_1151738_+\|tRNA-(guanosine(37)-N1)-methyltransferase-TrmD	gnl\|CDD\|234581	PRK00026, trmD, tRNA (guanine-N(1)-)-methyltransferase; Reviewed.	3.27017e-164

>NC_022113.1|WP_000167269.1|1140804_1141539_+|3-oxoacyl-[acyl-carrier-protein]-reductase
MTKSALVTGASRGIGRSIALQLAEEGYNVAVNYAGSKEKAEAVVEEIKAKGVDSFAIQANVADADEVKAMIKEVVSQFGSLDVLVNNAGITRDNLLMRMKEQEWDDVIDTNLKGVFNCIQKATPQMLRQRSGAIINLSSVVGAVGNPGQANYVATKAGVIGLTKSAARELASRGITVNAVAPGFIVSDMTDALSDELKEQMLTQIPLARFGQDTDIANTVAFLASDKAKYITGQTIHVNGGMYM
>NC_022113.1|WP_000047355.1|1139885_1140812_+|ACP-S-malonyltransferase
MSKTAIIFPGQGAQKVGMAQDLYNNNDQATEILTSAANTLDFDILETMFTDEEGKLGETENTQPALLTHSSALLAALKNLNPDFTMGHSLGEYSSLVAADVLSFEDAVKIVRKRGQLMAQAFPSGVGSMAAVLGLDFDKVDEICKSLSSDDKIIEPANINCPGQIVVSGHKALIDELVEKGKSLGAKRVMPLAVSGPFHSSLMKVIEEDFSSYINQFEWRDAKFPVVQNVNAQGETDKEVIKSNMVKQLYSPVQFINSTEWLIDQGVDHFIEIGPGKVLSGLIKKINRDVKLTSIQTLEDVKGWNEND
>NC_022113.1|WP_000239746.1|1138906_1139893_+|phosphate-acyltransferase-PlsX
MVKLAIDMMGGDNAPDIVLEAVQKAVEDFKDLEIILFGDEKKYNLNHERIEFRHCSEKIEMEDEPVRAIKRKKDSSMVKMAEAVKSGEADGCVSAGNTGALMSAGLFIVGRIKGVARPALVVTLPTIDGKGFVFLDVGANADAKPEHLLQYAQLGDIYAQKIRGIDNPKISLLNIGTEPAKGNSLTKKSYELLNQDHSLNFVGNIEAKTLMDGDTDVVVTDGYTGNMVLKNLEGTAKSIGKMLKDTIMSSTKNKIAGAILKKDLAEFAKKMDYSEYGGSVLLGLEGTVVKAHGSSNAKAFYSAIRQAKIAGEQNIVQTMKETVGESNE
>NC_022113.1|WP_001548538.1|1138329_1138902_+|transcription-factor-FapR
MRGETLKLKKDKRREAIRQQIDSNPFITDHELSDLFQVSIQTIRLDRTYLNIPELRKRIKLVAEKNYDQISSIEEQEFIGDLIQVNPNVKAQSILDITSDSVFHKTGIARGHVLFAQANSLCVALIKQPTVLTHESSIQFIEKVKLNDTVRAEARVVNQTAKHYYVEVKSYVKHTLVFKGNFKMFYDKRG
>NC_022113.1|WP_001151515.1|1136067_1138128_+|ATP-dependent-DNA-helicase-RecG
MAKVNLIESPYSLLQLKGIGPKKIEVLQQLNIHTVEDLVLYLPTRYEDNTVIDLNQAEDQSNVTIEGQVYTAPVVAFFGRNKSKLTVHLMVNNIAVKCIFFNQPYLKKKIELNQTITVKGKWNRVKQEITGNRVFLNSQGTQTQENADVQLEPVYRIKEGIKQKQIRDQIRQALNDVTIHEWLTDELREKYKLETLDFTLNTLHHPKSKEDLLRARRTYAFTELFLFELRMQWLNRLEKSSDEAIEIDYDLDQVKSFIDRLPFELTEAQKSSVNEIFRDLKAPIRMHRLLQGDVGSGKTVVAAICMYALKTAGYQSALMVPTEILAEQHAESLIALFGDSMNVALLTGSVKGKKRKILLEQLENRTIDCLIGTHALIQDDVIFHNVGLVITDEQHRFGVNQRQLLREKGAMTNVLFMTATPIPRTLAISVFGEMDVSSIKQLPKGRKPIITTWAKHEQYDKVLMQMTSELKKGRQAYVICPLIESSEHLEDVQNVVALYESLQQYYGVSRVGLLHGKLSADEKDEVMQKFSNHEIDVLVSTTVVEVGVNVPNATFMMIYDADRFGLSTLHQLRGRVGRSDQQSYCVLIASPKTETGIERMTIMTQTTDGFELSERDLEMRGPGDFFGVKQSGLPDFLVANLVEDYRMLEVARDEAAELIQSGVFFENTYQHLRHFVEENLLHRSFD
>NC_022113.1|WP_000623906.1|1134231_1135878_+|DAK2-domain-containing-protein
MISKINGKLFADMIIQGAQNLSNNADLVDSLNVYPVPDGDTGTNMNLTMTSGREEVENNLSKNIGELGKTFSKGLLMGARGNSGVILSQLFRGFCKNIESESEINSKLLAESFQAGVETAYKAVMKPVEGTILTVAKDAAQAAIEKANNTEDCIELMEYIIVKANESLENTPNLLAVLKEVGVVDSGGKGLLCVYEGFLKALKGEKVEAKVAKLDKDEFVHDEHDFHGVINTEDIIYGYCTEMMVRFGKNKKAFDEQEFRQDMSQFGDSLLVINDEEIVKVHVHTEYPGKVFNYGQQYGELIKLKVENMREQHREVIRKEQHTAKPKMETVETAIITISMGEGISEIFKSMGATHIISGGQTMNPSTEDIVKVIEQSKCKRAIILPNNKNILMASEQAASIVDAEAVVIPTKSIPQGISALFQYDVDATLEENKAQMADSVNNVKSGSLTYAVRDTKIDGVEIKKDAFMGLIEDKIVSSQSDQLTTVTELLNEMLADDSEILTVIIGQDAEQAVTDNMINWIEEQYPDVEVEVHEGGQPIYQYFFSVE
>NC_022113.1|WP_000171418.1|1133842_1134217_+|Asp23/Gls24-family-envelope-stress-response-protein
MTLEISNDYGKIDISNEVIASVVGGKAVECYGIVGMASRQQVRDGIAEILGHENYAKGIKVTENNGVVDIDMYIIVSYGVKISEVANNVQSTVKYTLEKSLNVSVNSINIYVQGVRVNNTGKKA
>NC_022113.1|WP_000517908.1|1133211_1133400_-|50S-ribosomal-protein-L28
MGKQCFVTGRKASTGNRRSHALNSTKRRWNANLQKVRILVDGKPKKVWVSARALKSGKVTRV
>NC_022113.1|WP_000547905.1|1132189_1132831_+|thiamine-diphosphokinase
MHINLLCSDRHLPQDIWAKSNEGKWGGVDRGALILLKHQIIPFFSVGDFDSVSKEERQLLTEQLQIKPVQAEKADTDLALAVDKAVALGFDSITIYGATGGRLDHFFGAIQLLLKKAYYKHDVHIEVIDQQNKIELLPKGQHTVEKDKSYPYISFIPMTDDVELSLAGFKYNLARQMLNIGSTLTISNEIESLQAKVTVHDGLILQIRSTDLN
>NC_022113.1|WP_000164332.1|1131538_1132183_+|ribulose-phosphate-3-epimerase
MTKLYPSLLSVDFLDLQHELKRLEEAGVDGVHFDVMDGQFVPNISIGLPILDAVRKGTTLPIDVHLMIENPEKYIASFAEHGADMISIHVESTPHIHRAIQMIKHLDKKAGVVINPGTPISQIEPILDIVDYVLVMTVNPGFGGQSFIDQCVEKIAGLNAIKMERQLNFDIEVDGGVNTDTAKVCVENGATMLVTGSFFFKQEDYKKVTQALKG
>NC_022113.1|WP_000426914.1|1141844_1142078_+|acyl-carrier-protein
MENFDKVKDIIVDRLGVDADKVTEDASFKDDLGADSLDIAELVMELEDEFGTEIPDEEAEKINTVGDAVKFINSLEK
>NC_022113.1|WP_000043237.1|1142193_1142925_+|ribonuclease-III
MSKQKKSEIVNRFRKRFDTKMTELGFTYQNIDLYQQAFSHSSFINDFNMNRLDHNERLEFLGDAVLELTVSRYLFDKHPNLPEGNLTKMRATIVCEPSLVIFANKIGLNEMILLGKGEEKTGGRTRPSLISDAFEAFIGALYLDQGLDIVWKFAEKVIFPHVEQNELLGVVDFKTQFQEYVHQQNKGDVTYNLIKEEGPAHHRLFTSEVILQGEAIAEGKGKTKKESEQRAAESAYKQLKQIK
>NC_022113.1|WP_000262715.1|1143071_1146638_+|chromosome-segregation-protein-SMC
MVYLKSIDAIGFKSFADQTNVQFDKGVTAIVGPNGSGKSNITDAIKWVLGEQSAKSLRGSKMEDIIFSGAEHRKAQNYAEVQLRLDNHSKKLSVDENEVIVTRRLYRSGESEYYINNDRARLKDIADLFLDSGLGKEAYSIISQGRVDEILNAKPIDRRQIIEESAGVLKYKKRKAESLNKLDQTEDNLTRVEDILYDLEGRVEPLKEEAAIAKEYKTLSHQMKHSDIVVTVHDIDQYTNDNRQLDQRLNDLQGQQANKEADKQRLSQQIQQYKGKRHQLDNDVESLNYQLVKATEAFEKYTGQLNVLVERKKNQSETNARYEEEQENLIELLENISSEISEAQDTYKSLKSKQKELNAVIRELEEQLYVSDEAHDEKLEEIKNEYYTLMSEQSDVNNDIRFLKHTIEENEVKKSRLDSRLVEVFEQLKDIQGQIKTTKKEYQQTNKELSAVDKEIKNIEKDLTDTKKAQNEYEEKLYQAYRYTEKMKTRIDSLATQEEEYTYFFNGVKHILKAKNKELKGIHGAVAEIIDVPSKLTQAIETALGASLQHVIVDSEKDGRQAIQFLKERNLGRATFLPLNVIQSRAVATDIKSIAKEANGFISIASEAVKVAPEYQNIIGNLLGNTIIVDHLKHANELARAIKYRTRIVTLEGDIVNPGGSMTGGGARKSKSILSQKDELTTMRHQLEDYLRQTESFEQQFKELKIKSDQLSELYFEKSQKHNTLKEQVHHFEMELDRLTTQETQIKNDHEEFEFEKNDGYTSDKSRQTLSEKETHLESIKASLKRLEDEIERYTKLSKEGKESLTKTQQTLHQKQSDLAVVKERIKTQQQTIDRLNNQSQQTKHQLNDVKEKIAFFNSDEVMGEQAFQNIKDQINGQQETRTRLSDELDKLKQQRIELNEQIDAQEATLQVCHQDILAIENHYQDIKAEQSKLDVLIHHAIDHLNDEYQLTVERAKSEYTSDESIDALRKKVKLMKMSIDELGPVNLNAIEQFEELNERYTFLSEQRTDLRKAKETLEQIISEMDQEVTERFKETFHAIQGHFTAMFKQLFGGGDAELQLTEADYLTAGIDIVVQPPGKKLQHLSLLSGGERALTAIALLFAILKVRSAPFVILDEVEAALDEANVIRYAKYLNELSDETQFIVITHRKGTMEFADRLYGVTMQESGVTKLVSVNLNTIDDVLKEEQ
>NC_022113.1|WP_000007673.1|1146637_1147888_+|signal-recognition-particle-docking-protein-FtsY
MSFFKRLKDKFATNKENDEVKSLTEEQGQDKLEDTHSEGSTQDVNDLAENAEVKKKPRKLSEADFDDDGLISIEDFEEIEAQKMGAKFKAGLEKSRQNFQEQLNNLIARYRKVDEDFFEALEEMLITADVGFNTVMTLTEELRMEAQRRNIQDTEDLREVIVEKIVEIYHQEDDNSEAMNLEDGRLNVILMVGVNGVGKTTTIGKLAYRYKMEGKKVMLAAGDTFRAGAIDQLKVWGERVGVDVISQSEGSDPAAVMYDAINAAKNKGVDILICDTAGRLQNKTNLMQELEKVKRVINRAVPDAPHEALLCLDATTGQNALSQARNFKEVTNVTGIVLTKLDGTAKGGIVLAIRNELHIPVKYVGLGEQLDDLQPFNPESYVYGLFADMIEQNEEITTVENDQIVTEEKDDNHGAK
>NC_022113.1|WP_000531319.1|1147874_1148207_+|putative-DNA-binding-protein
MGQNDLVKTLRMNYLFDFYQSLLTNKQRNYLELFYLEDYSLSEIADTFNVSRQAVYDNIRRTGDLVEDYEKKLELYQKFEQRREIYDEMKKHLSNPEQIQRYIQQLEDLE
>NC_022113.1|WP_000863477.1|1148232_1149600_+|signal-recognition-particle-protein
MAFEGLSERLQATMQKMRGKGKLTEADIKIMMREVRLALLEADVNFKVVKEFIKTVSERALGSDVMQSLTPGQQVIKIVQDELTKLMGGENTSINMSNKPPTVVMMVGLQGAGKTTTAGKLALLMRKKYNKKPMLVAADIYRPAAINQLQTVGKQIDIPVYSEGDQVKPQQIVTNALKHAKEEHLDFVIIDTAGRLHIDEALMNELKEVKDIAKPNEIMLVVDSMTGQDAVNVAESFDDQLDVTGVTLTKLDGDTRGGVALSIRSVTQKPIKFVGMSEKLDGLELFHPERMASRILGMGDVLSLIEKAQQDVDQEKAKDLEKKMRESSFTLDDFLEQLDQVKNLGPLDDIMKMIPGMNKMKGLDKLNMSEKQIDHIKAIIQSMTPAERNNPDTLNVSRKKRIAKGSGRSLQEVNRLMKQFNDMKKMMKQFTGGGKGKKGKRNQMQNMLKGMNLPF
>NC_022113.1|WP_000268754.1|1150034_1150310_+|30S-ribosomal-protein-S16
MAVKIRLTRLGSKRNPFYRIVVADARSPRDGRIIEQIGTYNPTSANAPEIKVDEALALKWLNDGAKPTDTVHNILSKEGIMKKFDEQKKAK
>NC_022113.1|WP_001261987.1|1150497_1151001_+|ribosome-maturation-factor-RimM
MRVEVGQIVNTHGIKGEIKVKSNSDFTDVRFQPGQVLTVVHNNNDLEYTVKSHRVHKGLHMLTFEGINNINDIEHLKGSSIYQERDHEDIVLEENEFYYSDIIGCTVFDDQETPIGRVINIFETGANDVWVIKGSKEYLIPYIADVVKEVDVENKKIIITPMEGLLD
>NC_022113.1|WP_000687323.1|1151000_1151738_+|tRNA-(guanosine(37)-N1)-methyltransferase-TrmD
MKIDYLTLFPEMFDGVLNHSIMKRAQENNKLQINTVNFRDYAINKHNQVDDYPYGGGQGMVLKPEPVFNAMEDLDVTEQARVILMCPQGEPFSHQKAVELSKADHIVFICGHYEGYDERIRTHLVTDEISMGDYVLTGGELPAMTMTDAIVRLIPGVLGNEQSHQDDSFSDGLLEFPQYTRPREFKGLTVPDVLLSGNHANIDAWRHEQKLIRTYNKRPDLIEKYPLTNADKQILERYKIGLKKG
>NC_022113.1|WP_000181404.1|1151840_1152191_+|50S-ribosomal-protein-L19
MTNHKLIEAVTKSQLRTDLPSFRPGDTLRVHVRIIEGTRERIQVFEGVVIKRRGGGVSETFTVRKISSGVGVERTFPLHTPKIEKIEVKRRGKVRRAKLYYLRSLRGKAARIQEIR

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Crispr_ID: NC_022113_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022113_7

1881813-1881903

Orphan

Consensus_repeat	Method
GACATTGCAAGTTGGGGAACGGGTCCAACATAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022113_7

>merge|NC_022113|7|1881813-1881903|CRISPRCasFinder
GACATTGCAAGTTGGGGAACGGGTCCAACATAGTGAAATCGGATTTCCAATTTCTACAGACATTGCAAGTTGGGGAACGGGTCCAACATAG

>NC_022113|7|7|1881813-1881903|CRISPRCasFinder
GACATTGCAAGTTGGGGAACGGGTCCAACATAG	TGAAATCGGATTTCCAATTTCTACA
GACATTGCAAGTTGGGGAACGGGTCCAACATAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_022113.1\|WP_000939529.1\|1898626_1899082_-\|thioredoxin-dependent-thiol-peroxidase	unknown	unknown	gnl\|CDD\|224146
NC_022113.1\|WP_000992513.1\|1874163_1875288_-\|DUF445-domain-containing-protein	unknown	unknown	gnl\|CDD\|226834
NC_022113.1\|WP_000437967.1\|1876933_1878046_-\|GAF-domain-containing-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NC_022113.1\|WP_000584640.1\|1868739_1871676_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|227061
NC_022113.1\|WP_000110011.1\|1897127_1897574_-\|peroxide-responsive-transcriptional-repressor-PerR	unknown	unknown	gnl\|CDD\|223806
NC_022113.1\|WP_000238227.1\|1871665_1872862_-\|exonuclease-SbcCD-subunit-D	unknown	unknown	gnl\|CDD\|223497
NC_022113.1\|WP_000063551.1\|1887181_1888243_-\|PTS-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|226167
NC_022113.1\|WP_000869463.1\|1897670_1898621_-\|phosphoglycerate-dehydrogenase	unknown	unknown	gnl\|CDD\|240632
NC_022113.1\|WP_000379980.1\|1883472_1884600_-\|tRNA-epoxyqueuosine(34)-reductase-QueG	unknown	unknown	gnl\|CDD\|272993
NC_022113.1\|WP_001045133.1\|1876288_1876912_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NC_022113.1\|WP_000649898.1\|1885465_1886923_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223836
NC_022113.1\|WP_000901019.1\|1881066_1881462_-\|hypothetical-protein	unknown	unknown	unknown
NC_022113.1\|WP_000181394.1\|1882997_1883468_-\|tRNA-(uridine(34)/cytosine(34)/5--carboxymethylaminomethyluridine(34)-2'-O)--methyltransferase-TrmL	unknown	unknown	gnl\|CDD\|223297
NC_022113.1\|WP_000590809.1\|1884750_1885473_-\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
NC_022113.1\|WP_000031108.1\|1882062_1882215_-\|hypothetical-protein	unknown	unknown	unknown
NC_022113.1\|WP_000375864.1\|1875466_1875931_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224393
NC_022113.1\|WP_000669380.1\|1878208_1879030_+\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638
NC_022113.1\|WP_001251219.1\|1882239_1882839_-\|glucosamine-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|223440
NC_022113.1\|WP_000116227.1\|1879485_1880871_-\|class-II-fumarate-hydratase	unknown	unknown	gnl\|CDD\|234779
NC_022113.1\|WP_001244175.1\|1867801_1868743_-\|3'-5'-exoribonuclease-YhaM	unknown	unknown	gnl\|CDD\|237394

Protein	Function_ID	Function_description	E-value
NC_022113.1\|WP_000939529.1\|1898626_1899082_-\|thioredoxin-dependent-thiol-peroxidase	gnl\|CDD\|224146	COG1225, Bcp, Peroxiredoxin [Posttranslational modification, protein turnover, chaperones].	1.18155e-68
NC_022113.1\|WP_000992513.1\|1874163_1875288_-\|DUF445-domain-containing-protein	gnl\|CDD\|226834	COG4399, COG4399, Uncharacterized protein conserved in bacteria [Function unknown].	9.41336e-162
NC_022113.1\|WP_000437967.1\|1876933_1878046_-\|GAF-domain-containing-sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	3.94275e-57
NC_022113.1\|WP_000584640.1\|1868739_1871676_-\|AAA-family-ATPase	gnl\|CDD\|227061	COG4717, COG4717, Uncharacterized conserved protein [Function unknown].	0
NC_022113.1\|WP_000110011.1\|1897127_1897574_-\|peroxide-responsive-transcriptional-repressor-PerR	gnl\|CDD\|223806	COG0735, Fur, Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism].	6.09298e-56
NC_022113.1\|WP_000238227.1\|1871665_1872862_-\|exonuclease-SbcCD-subunit-D	gnl\|CDD\|223497	COG0420, SbcD, DNA repair exonuclease [DNA replication, recombination, and repair].	7.33172e-64
NC_022113.1\|WP_000063551.1\|1887181_1888243_-\|PTS-transporter-subunit-IIC	gnl\|CDD\|226167	COG3641, PfoR, Predicted membrane protein, putative toxin regulator [General function prediction only].	1.65132e-122
NC_022113.1\|WP_000379980.1\|1883472_1884600_-\|tRNA-epoxyqueuosine(34)-reductase-QueG	gnl\|CDD\|272993	TIGR00276, iron-sulfur_cluster-binding_protein, epoxyqueuosine reductase. This model was rebuilt to exclude archaeal homologs, now that there is new information that bacterial members are epoxyqueuosine reductase, QueG, involved in queuosine biosynthesis for tRNA maturation. [Protein synthesis, tRNA and rRNA base modification].	6.7316e-180
NC_022113.1\|WP_001045133.1\|1876288_1876912_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	3.11819e-78
NC_022113.1\|WP_000649898.1\|1885465_1886923_-\|ABC-transporter-permease-subunit	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	2.55367e-98
NC_022113.1\|WP_000869463.1\|1897670_1898621_-\|phosphoglycerate-dehydrogenase	gnl\|CDD\|240632	cd12155, PGDH_1, Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family. Phosphoglycerate Dehydrogenase (PGDH) catalyzes the NAD-dependent conversion of 3-phosphoglycerate into 3-phosphohydroxypyruvate, which is the first step in serine biosynthesis. Over-expression of PGDH has been implicated as supporting proliferation of certain breast cancers, while PGDH deficiency is linked to defects in mammalian central nervous system development. PGDH is a member of the 2-hydroxyacid dehydrogenase family, enzymes that catalyze the conversion of a wide variety of D-2-hydroxy acids to their corresponding keto acids. The general mechanism is (R)-lactate + acceptor to pyruvate + reduced acceptor. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-Adenosylhomocysteine Hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann-fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric.	8.45391e-136
NC_022113.1\|WP_000181394.1\|1882997_1883468_-\|tRNA-(uridine(34)/cytosine(34)/5--carboxymethylaminomethyluridine(34)-2'-O)--methyltransferase-TrmL	gnl\|CDD\|223297	COG0219, CspR, Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis].	1.70324e-88
NC_022113.1\|WP_000590809.1\|1884750_1885473_-\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	4.70748e-153
NC_022113.1\|WP_000375864.1\|1875466_1875931_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224393	COG1476, COG1476, Predicted transcriptional regulators [Transcription].	5.18868e-15
NC_022113.1\|WP_000669380.1\|1878208_1879030_+\|RluA-family-pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	3.57209e-78
NC_022113.1\|WP_001251219.1\|1882239_1882839_-\|glucosamine-6-phosphate-isomerase	gnl\|CDD\|223440	COG0363, NagB, 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism].	9.77274e-11
NC_022113.1\|WP_000116227.1\|1879485_1880871_-\|class-II-fumarate-hydratase	gnl\|CDD\|234779	PRK00485, fumC, fumarate hydratase; Reviewed.	0
NC_022113.1\|WP_001244175.1\|1867801_1868743_-\|3'-5'-exoribonuclease-YhaM	gnl\|CDD\|237394	PRK13480, PRK13480, 3'-5' exoribonuclease YhaM; Provisional.	0

>NC_022113.1|WP_000901019.1|1881066_1881462_-|hypothetical-protein
MLGKYWIQLLIATVIISLISIKAFPLAIGALYLPIIFKVIKLQLNLSKGLIDDVNAQTFIKSNQSGIVISVICCLLITGILYYTLDGFYASLTGVLGTLVALNPYTTIVSAVLYILTAIATVEATKTKYRN
>NC_022113.1|WP_000116227.1|1879485_1880871_-|class-II-fumarate-hydratase
MSVRIEHDTFGEIEVPADKYWGAQTERSKRNFPVGKERMPIEVVYGFAQLKRAAALANFDLGKLSEAKKDAIVYACDQILSGELDEHFPLVVWQTGSGTQSNMNVNEVVSYVANMYLKDHHSDESIHPNDDVNKSQSSNDTFPTAMHVALYQEVETKLEPALKLLRNTLKEKEDKFDSIIKIGRTHLQDATPIKLGQEISGWRYMLDRCETMLSESKKHILNLAIGGTAVGTGINAHPEFGDKVAQYISENTGYPFVSSENKFHALTAHDEVVQLHGTLKALAGDLMKIANDVRWLASGPRAGLAEISIPENEPGSSIMPGKVNPTQCEMLTMVAVQVMGNDTVVGFASSQGNFELNVYKPVIMHNTLQSIYLLADGMETFNNNCAVGIEPIEENIDNYLNQSLMLVTALNPHIGYEKAAQIAKKAHKEGLTLKESAIQTGYVTEEQFEAWIKPEDMVDPH
>NC_022113.1|WP_000669380.1|1878208_1879030_+|RluA-family-pseudouridine-synthase
MKFKIPENFNDLSLRDIFQQLKVPKKDLHHLNMSKDITINDKPARLMDKVHTGDDVFVPTIDEKSNYVPSYRYAQIKYEDDDMAIVMKPKGVKTHPNDLKESNTLMNHVIYTVDSDYVEPIHRLDQETVGLLIVAKNPLMKKILDRMLEDNDITRIYKANVKALLPLKPQTIDMPIGKDKFHSNKRRVSPTGQRAITHILTSKMIKETVCQLEIKLDTGRTHQIRVHLAEIGHPVIGDPLYGDSTLRQLELESYKIEFVHPLTKEVISVSLDD
>NC_022113.1|WP_000437967.1|1876933_1878046_-|GAF-domain-containing-sensor-histidine-kinase
MEQRTRLALLKEIAEFLNEETEMYSMTQGALKYLIEGSNFTTGWIFFINSVGEHELVSHVALPQSLTADHCHYIKDGSCWCVKAFNQRRLMKASNIVNCSRINLASKAFPSQNDNITHHATVPLKSGQEQFGILNVASPNTEIYSDEDLELLESVAFQLGSAIKRIYLTDREKEAAKINERNRLARDLHDSVNQMLFSVKLTAHAAYGMSNESIAKQAFKTIEETSQNAVNEMRALIWQLKPVGLEQGLIHALTAYSKLMHIQLNVNVEGLIDLSNEIEENIYRALQECINNVKKHADTNKMDLTLKQMNDILYIDVIDYGQGFEIDNVQIASSHGINNIKQRVKLLRGKVTFHSQPTKGTQIQFTIPIK
>NC_022113.1|WP_001045133.1|1876288_1876912_-|response-regulator-transcription-factor
MNKVILVDDHYIVRQGLRFLLSTIENIEVLQDFADGETFLEYLKEHEHPDIVLLDLVMPGMNGIEITEYIKAHYPDIKVLVLTSYVDDEHVISAINKGADGYEMKDVEPQQLIETIRRVMNGEKMIHPKAQDVFETVSQKPHYTNKLSKREIEVLREMVKGKTNKEIAETLFVSEKTIKTHVSHIFSKLQVSDRTQAAIYAMENKLI
>NC_022113.1|WP_000375864.1|1875466_1875931_-|helix-turn-helix-transcriptional-regulator
MDRQSFTDLIQTKFKMVRIEAGYTQDTMAQTIGLSKKTLVQIEKERVLPNWTTCISICALFRDSEVLNSTFGCDPLEIVQTISRNHCAYPNHAPTSDIYWNNIETRNGYILQSNKVSNIYRVLNPDNQPIFGTSKMREAETYFNRNAKEELVHI
>NC_022113.1|WP_000992513.1|1874163_1875288_-|DUF445-domain-containing-protein
MNALFIIIFMIVVGAIIGGITNVIAIRMLFHPFKPYYIFKFRVPFTPGLIPKRREEIATKIGQVIEEHLLTETLINEKLKSEQSQQAIESMIQQQLQKLTKDQLSIKQITSQIDIDLEQVLQTNGNQYIASQLNNYYTKHQNQTIASLLPNQLVTFLDQHVDNATDLLCDRARNYLSSAKGTQDINDMLDTFFNEKGKLIGMLQMFMTKESIADRIQQELIRLTSHPKARAIVTSLITNEYQTFKDKSLNKLLDTSQFNEIAENLSMYVTTYASKQANKPVVTLMPQFVDYLESQLSSKLANLIIEQLSIHLSTIMKKVDLRGLIEEQINTFDLDYIEKLIIEIANKELKLIMSLGFILGGIIGFFQGLVAIFV
>NC_022113.1|WP_000238227.1|1871665_1872862_-|exonuclease-SbcCD-subunit-D
MVKFIHCSDLHLDSPFKSKSHISPKIFEDVQKSAYESFKNIVDIALQQDVDFVIIAGDLFDSENRTLRAEIFLKQQFERLQNEQIFVYVCHGNHDPLSSKISSNWPDNVSVFSNKVETYEAITKSGETIYIHGFSYENRASYENKIDEYPSSQGQKGIHIGVLHGTYSKSSVNERYTEFILEDLNSKLYHYWALGHIHERQQLSDMPVINYSGNIQGRHFNEQGEKGCLLIEGDHLKLKTKFYPTQYIRFEEATIETDKTSKQGLYEVIQNFKEQVREEGKAFYRLTLVINSETLISPQDLLQVEEMITDYEENENQFVYIDELKIQYAQNDESPLVNEFSAELLVDQTVFDKAMSDLYLNPRASKFLDDYGTFDHTALVNRAEEILKAEMRGEQNDN
>NC_022113.1|WP_000584640.1|1868739_1871676_-|AAA-family-ATPase
MIIKSLEIYGYGQFVQRKIEFNKNFTEIFGENEAGKSTIQAFIHSILFGFPTKKSKEPRLEPRLGNQYGGKLVLILDDGLEIEVERIKGSAQGDVKVYLPNGAVRDDAWLQKKLNYISKKTYQGIFSFDVLGLQDIHRNLNEKQLQDYLLQAGALGSTEFTSMREVINRKKDELYKKSGKNPIINQQIEQLKQLESQIREEEAKLETYHRLVDDRDKSSRRLENLKHNLNQLSKMHEEKQKEVALHDHSQEWKSLEQQLNIEPITFPEKGVDRYEKARAHKQSLERDIGLRNERLAQLKEEATQLEPVKQSDIDAFISLNQQENEIKNKEFELTAIEKDIANKQRDKDELQANIGWSETHHDVDSSEAMKSYVSEQIKNKQEQAAYIKQLERSLEENKIEDNAVHSELDSVEEKIVPEETFEKKKEYSQQVIELNEKENLYSKLKERFEIEQQEKQKRQKLLRTTFILLTLVGIGLTVFSFISNNMLFGIIFAVLTLVFVIGIIMSKSKEVYYSEAITDEIEVIKAQLAILGENYDLDFDLDEQYRIRDHWQQALKNKDILEEKRQYIEGRLNDAKGRHDELQSTVENVKDELYLSSKISNDLIVDSISTMANIKALDQHISDLNQQRQQLVQELDTFYNHAEAVTKSQFVYFNKLSLFHDVQQWLKSAEDTNEKWRINAENTKLVTNELNHLNAQLEENNKEITALFDFINVGTEEDFYQHHEDYQTYTSNLSRFNDLTKYLENQNYSYELSSSLSEKTTAQLEEEDHLLATQVDEYNEQYLEMQAQVSDLSAQINHMETDTTLANLRHEYHSLKNQLNDIAKDWASLSYLQSLVDEHIKQIKDKRLPQVINEAVEILKHLTDGRYTMINYNEDSITVKHVNGQLYDPVELSQSTKELLYVALRISLIKVLRPYYPFPLIVDDAFVHFDKKRTEKMLNYLRSLSEHYQVLYFTCVKDNIVPSKEVITLNKIEEGGKR
>NC_022113.1|WP_001244175.1|1867801_1868743_-|3'-5'-exoribonuclease-YhaM
MRNIENLNPGDSVDHFFLVHKATQGVTAQGKDYMTLHLQDKSGEIEAKFWTATKNDMATIKPEEIVHVKGDIINYRGNKQMKVNQIRLATTEDQLKTEQFVDGAPLSPAEIQEEISHYLLDIENANLQRITRHLLKKYQERFYTYPAASSHHHNFASGLSYHVLTMLRIAKSICDIYPLLNKSLLYSGIILHDIGKVRELSGPVATSYTVEGNLLGHISIASDEVVEAARELNIEGEEIMLLRHMILSHHGKLEYGSPKLPYLKEAEILCYIDNIDARMNMFEKAYKKTDKGQFTDKIFGLENRRFYNPESLD
>NC_022113.1|WP_000031108.1|1882062_1882215_-|hypothetical-protein
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ
>NC_022113.1|WP_001251219.1|1882239_1882839_-|glucosamine-6-phosphate-isomerase
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGVPAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGKTSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA
>NC_022113.1|WP_000181394.1|1882997_1883468_-|tRNA-(uridine(34)/cytosine(34)/5--carboxymethylaminomethyluridine(34)-2'-O)--methyltransferase-TrmL
MTNHIVLYQPEIPANTGNIARTCAGTNTHLHLIKPLGFRTDDKMLKRAGLDYWEFVNITYHDSIEAFFEATNGEYYLLTKFGKKTYSDFDFSNHDKDFYFIFGKETTGLPDWVKEKYQDTALRIPMSEHIRSLNLSNTAALLIYEALRQQDFPGLN
>NC_022113.1|WP_000379980.1|1883472_1884600_-|tRNA-epoxyqueuosine(34)-reductase-QueG
MDTKQLKQDIIDYAYTIGIDSIGFTTADPFDELKQKLEAYHANGYASGFEESDIALRTEPKLSLPTARSIIAIAVGYPNKLKGAPKSVRGDRRGLFARASWGQDYHTIMRKRLDMLAAFIESKVPDVEIKSMVDTGVLSDRAVAERAGLGFVGRNGFVINPKLGTWTYLGEMLVSIPFEPDDPLLDSCGDCTICVDRCPTSALVGNGQLNSQKCISFLTQTKGYMPDQYRYKIGNRLYGCDTCQQVCPKNRGINTEQDDIILEPEILKPRLVPLLRMSNKEFKQTYGHLAGAWRGKKPIQRNAILALAHFNEVDAIPELKKVATTDERPMIRATAYWAIGQILGEEARDFINANYDQEDAEVQNEMIKGLDTRRE
>NC_022113.1|WP_000590809.1|1884750_1885473_-|amino-acid-ABC-transporter-ATP-binding-protein
MIKINNLNKVFGDNEVLKDINLEINQGEVVAIIGPSGSGKSTLLRCMNLLEVPTKGQVIFEGNDLTEKGTQVDKLRQKMGMVFQNFNLFPHKKVVDNIILAPKLLKKDNNDELHKEALSLLDKVGLKEKADVYPNQLSGGQKQRVAIARALAMHPDVILFDEPTSALDPEVVGDVLKVMKDLAKEGMTMVVVTHEMGFAKDVSDKVIFMADGVVVESGTPVEIFEQPQHERTQNFLARVL
>NC_022113.1|WP_000649898.1|1885465_1886923_-|ABC-transporter-permease-subunit
MKCLIRFILVLGLLISSAMVYINPAAYAEQDQKWEKIKERGELRVGLSADYAPMEFEHTVNGKTEYAGVDIDLAKKIAKDNNLKLKIVNMSFDSLLGALKTGKIDIIISGMTSTPERKKQVDFSDSYMMTKNIMLVKKDKVNDYKDIKDFNNKKVGAQKGTEQEKIAQTEIENASITSLSRLPDVILALKSGKVEGVVVEKPVAEAYLKQNPKLGISNVKFNEEEKDTVIAVPKDSPKLLSQINKTIKEVKDKGLIDKYMTNAANAMNDDSGFISKYGSFFLKGIKITILISLIGVALGSILGAFVALMKLSKIKIISWIASIYIEILRGTPMLVQVFIVFFGITAALGLDISALVCGTIALVINSSAYIAEIIRAGINAVDKGQMEAARSLGLNYRQTMKSVIMPQAIKNILPALGNEFVTLIKESSIVSTIGVGEIMFNAQVVQGISFDPFTPLLVAAALYFVLTFVLTRIMNMIEGRLNASD
>NC_022113.1|WP_000063551.1|1887181_1888243_-|PTS-transporter-subunit-IIC
MSNAKNADNKQFFSKILNSIGAGVVIALVPNALLGEVLKIFKSGNEILELTYQLVILIQSFMAFIIGVLAAHQFKFNGAGAAIVGTSAMIGSGAVVYSNNSFMLKGIGDIINTSLVVIIACLIYMVLQNKLGSFELIILPVLVPIVSGGIGLITLPYIRKITQAIGNVIHSFTDLNPLLMSILISVAFSLLMVTPISLVAIATAISLNGLGSGAANLGIVAACVTFLFGSLRVNSIGVNAVLLIGAAKMMIPVYLKNLIISIPLTINGIITGIIAYVLQVKGTPLSAGFGYTGLVGPINAFNRMSGDPTMNIILLALGYFVIPFVSAFIVHELCKKFIPIYSNDIYKFEVPKQ
>NC_022113.1|WP_000110011.1|1897127_1897574_-|peroxide-responsive-transcriptional-repressor-PerR
MSVEIESIEHELEESIASLRQAGVRITPQRQAILRYLISSHTHPTADEIYQALSPDFPNISVATIYNNLRVFKDIGIVKELTYGDSSSRFDFNTHNHYHIICEQCGKIVDFQYPQLNEIERLAQHMTDFDVTHHRMEIYGVCKECQDK
>NC_022113.1|WP_000869463.1|1897670_1898621_-|phosphoglycerate-dehydrogenase
MKVVGLNRMREVETELQQRFSDVDFKFYKKASEIPESDLANLDILVGYDGGINEAFLRRCPNLKWIAWFATGVNTLPLDYIADHGILLTNGKGVQAKQLSEYILAFILDDYKKMKLSYDNQRQHIYDSKITGKRLSGQTVLFLGTGAIATRTAKLAKAFNMNLIGLSKSGQNKDEFDEIYTIESLESTLPNADIVINALPETQETIHLLKKKHFELMKDEALFINIGRGSIVKEALLIEVLKSRVIRHAYLDVFENEPLKPNHELYELDNVTITAHITGNDYEAKYDLLDIFKNNLVNFLNKNGLIENEVDAKKGY
>NC_022113.1|WP_000939529.1|1898626_1899082_-|thioredoxin-dependent-thiol-peroxidase
MLQKGEQFPIFKLENQDGTVITNDTLKGKKAIVYFYPRDNTPTCTTEACDFRDNLEMFNDLDVAVYGISGDSKKKHQNFIEKHGLNFDLLVDEDFKLAKETGVYQLKKSFGKESMGIVRTTFIIDEQGKVLDVIEKVKVKTQIEELKNILG

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Crispr_ID: NC_022113_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022113_8

1923117-1923200

Orphan

Consensus_repeat	Method
CCCCAACTTGCATTGCCTGTAGAA	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of NC_022113_8

>merge|NC_022113|8|1923117-1923200|CRISPRCasFinder
CCCCAACTTGCATTGCCTGTAGAATTTCTTTTTTCGAAATTCTCTGTGTTGGGGCCCACACCCCAACTTGCATTGCCTGTAGAA

>NC_022113|8|8|1923117-1923200|CRISPRCasFinder
CCCCAACTTGCATTGCCTGTAGAA	TTTCTTTTTTCGAAATTCTCTGTGTTGGGGCCCACA
CCCCAACTTGCATTGCCTGTAGAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_022113.1\|WP_000548777.1\|1930548_1931079_-\|DUF3267-domain-containing-protein	unknown	unknown	gnl\|CDD\|378690
NC_022113.1\|WP_001017131.1\|1919866_1920910_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NC_022113.1\|WP_000228670.1\|1916893_1917358_+\|low-molecular-weight-phosphotyrosine-protein-phosphatase	unknown	unknown	gnl\|CDD\|319971
NC_022113.1\|WP_001110177.1\|1921622_1922009_-\|hypothetical-protein	unknown	unknown	unknown
NC_022113.1\|WP_000544973.1\|1925381_1926113_-\|type-1-glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|225974
NC_022113.1\|WP_001793983.1\|1915287_1916544_-\|aminopeptidase	unknown	unknown	gnl\|CDD\|376723
NC_022113.1\|WP_000140179.1\|1929231_1930302_-\|DNA-polymerase-IV	unknown	unknown	gnl\|CDD\|235035
NC_022113.1\|WP_000613738.1\|1928610_1929165_+\|3'-5'-exonuclease	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|99834
NC_022113.1\|WP_000180460.1\|1916546_1916747_-\|DUF1128-family-protein	unknown	unknown	gnl\|CDD\|227177
NC_022113.1\|WP_001250339.1\|1926114_1927428_-\|lipid-II-isoglutaminyl-synthase-subunit-MurT	unknown	unknown	gnl\|CDD\|223840
NC_022113.1\|WP_000636142.1\|1922225_1922984_-\|type-I-methionyl-aminopeptidase	unknown	unknown	gnl\|CDD\|235576
NC_022113.1\|WP_001014423.1\|1923568_1924555_+\|aromatic-acid-exporter-family-protein	unknown	unknown	gnl\|CDD\|226614
NC_022113.1\|WP_000037081.1\|1917917_1919135_+\|YihY/virulence-factor-BrkB-family-protein	unknown	unknown	gnl\|CDD\|224214
NC_022113.1\|WP_001790257.1\|1925185_1925296_-\|hypothetical-protein	unknown	unknown	unknown
NC_022113.1\|WP_000949466.1\|1927719_1928220_+\|H-type-ferritin-FtnA	unknown	unknown	gnl\|CDD\|224445
NC_022113.1\|WP_001643743.1\|1924743_1925157_-\|hypothetical-protein	unknown	unknown	unknown
NC_022113.1\|WP_000153535.1\|1919247_1919877_-\|two-component-system-response-regulator-VraR	unknown	unknown	gnl\|CDD\|225107
NC_022113.1\|WP_001790679.1\|1928301_1928394_-\|hypothetical-protein	unknown	unknown	unknown
NC_022113.1\|WP_000149064.1\|1920906_1921608_-\|cell-wall-active-antibiotics-response-protein	unknown	unknown	gnl\|CDD\|227100
NC_022113.1\|WP_000428172.1\|1917364_1917640_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_022113.1\|WP_001017131.1\|1919866_1920910_-\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	6.78722e-72
NC_022113.1\|WP_000228670.1\|1916893_1917358_+\|low-molecular-weight-phosphotyrosine-protein-phosphatase	gnl\|CDD\|319971	cd16343, LMWPTP, Low molecular weight protein tyrosine phosphatase. Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.	5.12846e-65
NC_022113.1\|WP_000548777.1\|1930548_1931079_-\|DUF3267-domain-containing-protein	gnl\|CDD\|378690	pfam11667, DUF3267, Putative zincin peptidase. This family of proteins has a conserved HEXXH motif, suggesting the members are putative peptidases of zincin fold.	1.54005e-11
NC_022113.1\|WP_000544973.1\|1925381_1926113_-\|type-1-glutamine-amidotransferase	gnl\|CDD\|225974	COG3442, COG3442, Predicted glutamine amidotransferase [General function prediction only].	1.79354e-120
NC_022113.1\|WP_001793983.1\|1915287_1916544_-\|aminopeptidase	gnl\|CDD\|376723	pfam02073, Peptidase_M29, Thermophilic metalloprotease (M29).	0
NC_022113.1\|WP_000140179.1\|1929231_1930302_-\|DNA-polymerase-IV	gnl\|CDD\|235035	PRK02406, PRK02406, DNA polymerase IV; Validated.	0
NC_022113.1\|WP_000613738.1\|1928610_1929165_+\|3'-5'-exonuclease	gnl\|CDD\|99834	cd06130, DNA_pol_III_epsilon_like, an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III. This subfamily is composed of uncharacterized bacterial proteins with similarity to the epsilon subunit of DNA polymerase III (Pol III), a multisubunit polymerase which is the main DNA replicating enzyme in bacteria, functioning as the chromosomal replicase. The Pol III holoenzyme is a complex of ten different subunits, three of which (alpha, epsilon, and theta) compose the catalytic core. The Pol III epsilon subunit, encoded by the dnaQ gene, is a DEDDh-type 3'-5' exonuclease which is responsible for the proofreading activity of the polymerase, increasing the fidelity of DNA synthesis. It contains three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. The epsilon subunit of Pol III also functions as a stabilizer of the holoenzyme complex.	4.39188e-75
NC_022113.1\|WP_000180460.1\|1916546_1916747_-\|DUF1128-family-protein	gnl\|CDD\|227177	COG4840, COG4840, Uncharacterized protein conserved in bacteria [Function unknown].	9.24488e-25
NC_022113.1\|WP_001250339.1\|1926114_1927428_-\|lipid-II-isoglutaminyl-synthase-subunit-MurT	gnl\|CDD\|223840	COG0769, MurE, UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane].	3.60835e-98
NC_022113.1\|WP_000636142.1\|1922225_1922984_-\|type-I-methionyl-aminopeptidase	gnl\|CDD\|235576	PRK05716, PRK05716, methionine aminopeptidase; Validated.	1.9498e-126
NC_022113.1\|WP_001014423.1\|1923568_1924555_+\|aromatic-acid-exporter-family-protein	gnl\|CDD\|226614	COG4129, COG4129, Predicted membrane protein [Function unknown].	9.69605e-76
NC_022113.1\|WP_000037081.1\|1917917_1919135_+\|YihY/virulence-factor-BrkB-family-protein	gnl\|CDD\|224214	COG1295, Rbn, Ribonuclease BN family enzyme [Replication, recombination, and repair].	2.99224e-85
NC_022113.1\|WP_000949466.1\|1927719_1928220_+\|H-type-ferritin-FtnA	gnl\|CDD\|224445	COG1528, Ftn, Ferritin-like protein [Inorganic ion transport and metabolism].	1.15329e-74
NC_022113.1\|WP_000153535.1\|1919247_1919877_-\|two-component-system-response-regulator-VraR	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.75115e-79
NC_022113.1\|WP_000149064.1\|1920906_1921608_-\|cell-wall-active-antibiotics-response-protein	gnl\|CDD\|227100	COG4758, COG4758, Predicted membrane protein [Function unknown].	9.42019e-79

>NC_022113.1|WP_000636142.1|1922225_1922984_-|type-I-methionyl-aminopeptidase
MIVKTEEELQALKEIGYICAKVRNTMQAATKPGITTKELDNIAKELFEEYGAISAPIHDENFPGQTCISVNEEVAHGIPSKRVIREGDLVNIDVSALKNGYYADTGISFVVGESDDPMKQKVCDVATMAFENAIAKVKPGTKLSNIGKAVHNTARQNDLKVIKNLTGHGVGLSLHEAPAHVLNYFDPKDKTLLTEGMVLAIEPFISSNASFVTEGKNEWAFETSDKSFVAQIEHTVIVTKDGPILTTKIEEE
>NC_022113.1|WP_001110177.1|1921622_1922009_-|hypothetical-protein
MNYVERYIEQFLRATVRKNIKHYLLMLDEKMKNLDDYMHYLITKKEQLSKLIDSLMLTLENKYIDIVEAFQIQCAREINNQEIENIKSELNKVEAYYAQIETQIQQTSTEKIATEKTSYLINYMNAVA
>NC_022113.1|WP_000149064.1|1920906_1921608_-|cell-wall-active-antibiotics-response-protein
MTHKYISTQMLIIFTALMIIANFYYIFFEKIGFLLVLLLGCVLVYVGYLYFHKIRGLLAFWIGALLIAFTLLSNKYTIIILFVFLLLLIVRYLIHKFKPKKVVATDEVMTSPSFIKQKWFGEQRTPVYVYKWEDVQIQHGIGDLHIDLTKAANIKENNTIVVRHILGKVQVILPVNYNINLHVAAFYGSTYVNEKSYKVENNNIHIEEMMKPDNYTVNIYVSTFIGDVEVIYR
>NC_022113.1|WP_001017131.1|1919866_1920910_-|sensor-histidine-kinase
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKTQIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVSQQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEIQDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGATFHIVSLPDSGTRIEVKAPLNKEDSYDD
>NC_022113.1|WP_000153535.1|1919247_1919877_-|two-component-system-response-regulator-VraR
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMEDMDGVEATTQIKKDLPQIKVLMLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSRGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIAKGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ
>NC_022113.1|WP_000037081.1|1917917_1919135_+|YihY/virulence-factor-BrkB-family-protein
MSKKDHSSSKYLNSVKEAQEESKKKNKSNPKIDVDRTYIEPQQFQSKKPKKDDQVFFLSRLNKPAKYKKDSNFLSYLIYRIGKDDASGLAAQMTYHFVLAMFPMLLFLLTLLPFFNIKQSQITNMLSNAPAETSTLIKSVIGDITQNSSGGLLSIGLILAIWSASNGMTAIMNSFNVAYDVEDSRNGIVLKLLSVVFTVVMGVVFVVALALPTLGSVISHFLFGPLGFDEQVKWIFNLIRIVLPIIIIFIVFIVLYSVAPNVKTKLKSVLPGAVFTSIIWLAGSFGFGWYISNFGNYSKTYGSIAGIIILLLWLYITSFIIIVGAEINAIIHQRSVIKGKTPEEAALEHDDNNKNHYNENTRYEYDEDTNATHQRTYHVDEHPSDTYPEDDKNIKDKIVDKLKKD
>NC_022113.1|WP_000428172.1|1917364_1917640_+|hypothetical-protein
MENKFVPGILIGAVIGGAISLADKSTRQALVQSVKDAKNGNRTRKPSKVSKIKDEVLYWKDVVEEIRRNNPELERSLKDAKETFVNRKNQR
>NC_022113.1|WP_000228670.1|1916893_1917358_+|low-molecular-weight-phosphotyrosine-protein-phosphatase
MVDVAFVCLGNICRSPMAEAIMRQRLKDRNIQDIKVHSRGTGSWNLGEPPHEGTQKILNKHNIPFDGMISELFEATDDFDYIVAMDQSNVDNIKSINPNLKGQLFKLLEFSNMEESDVPDPYYTNNFEGVYDMVLSSCDNLIDYIVKDANLKEG
>NC_022113.1|WP_000180460.1|1916546_1916747_-|DUF1128-family-protein
MTNEEKVLAIREKLNIVNQGLLDPEKYKNANEEELTDIYDFVQSRERLSPSEVTAIADALGQLRHD
>NC_022113.1|WP_001793983.1|1915287_1916544_-|aminopeptidase
MGILTNYKEKLQQYAELLVKVGMNVQPKQPVFIRSSVETLELTHLIVEEAYRCGASDVRVVYSDPTLKRLKFENESVEHFANHEIKSYDVEARMDYVKRGAANLALISEDPDLMDGIDSQKLQAFQQQNARAFKGYMESVQKNQFPWVVAAFPSKAWAKRVYPELSVEEAYIKFIDEVFDIVRIDGNDPVENWRQHIANLSVYAQKLQQKNYHALHYVSEGTDLTVGLAKNHIWEDATSYVNGKEQAFIANIPTEEVFTAPDRNRVDGYVTNKLPLSYNGTIIDQFKLMFKDGEIIDFSAEKGEAVLKDLINTDEGSRRLGEVALVPDDSPISNRNTIFYNTLFDENAACHLAIGSAYAFNIQGGTEMTVEEKIASGLNDSNVHVDFMIGSSDLTIYGIFEDGSKELVFENGNWASTF
>NC_022113.1|WP_001014423.1|1923568_1924555_+|aromatic-acid-exporter-family-protein
MNGQWYKHLIGARTIKTGIAIFLTAVFCMALDLTPIYAILTAVVTIEPTAKASLIKGYRRLPATVIGAGFAVLFTYLFGDQSPFTYALSATFTILFCTKLKLQVGTNVAVLTSLAMIPGIHDAYIFNFLSRTLTAIIGLVTSGLINFMVFPPKYYGQVEEKLSKTDALMYKLFYNRCQEIILSRLQSDKSEKAYKNIFNLNNQVETLISYQRDELSYHKKKECDWKLLNQLTKRAYTNRLFITHLSNIIYLPKNTRVNFSGDEKMALLKISSSIKDIFYDGSFKREDDSVETLRSTIKALEISGENQIKSHILYEVLMIYRLLDSRYA
>NC_022113.1|WP_001643743.1|1924743_1925157_-|hypothetical-protein
MKPTKVILKDASYLHSKTSITFILKDVVIEEDNKIYYFDTSATFEDQEIKFEFALFDSDMDNLKYIEYDNPVTEIYFIEPDLHFTIIDFNQELLCIYIDFDSGLRHSNMVTESGVSLRINVTKSGFTKFINELVSLH
>NC_022113.1|WP_001790257.1|1925185_1925296_-|hypothetical-protein
MDGNNQIDVCFFVLVNNYYTMSIYPRIINSNGDYAT
>NC_022113.1|WP_000544973.1|1925381_1926113_-|type-1-glutamine-amidotransferase
MHELTIYHFMSDKLNLYSDIGNIIALRQRAKKRNIKVNVVEINETEGITFDECDIFFIGGGSDREQALATKELSKIKTPLKEAIEDGMPGLTICGGYQFLGKKYITPDGTELEGLGILDFYTESKTNRLTGDIVIESDTFGTIVGFENHGGRTYHNFGTLGHVTFGYGNNDEDKKEGIHYKNLLGTYLHGPILPKNYEITDYLLEKACERKGIPFEPKEIDNEAEKQAKQVLIDRANRQKKSR
>NC_022113.1|WP_001250339.1|1926114_1927428_-|lipid-II-isoglutaminyl-synthase-subunit-MurT
MRQWTAIHLAKLARKASRAVGKRGTDLPGQIARKVDTDILRKLAEQVDDIVFISGTNGKTTTSNLIGHTLKANNIQIIHNNEGANMAAGITSAFIMQSTPKTKIAVIEIDEGSIPRVLKEVTPSMMVFTNFFRDQMDRFGEIDIMVNNIAETISNKGIKLLLNGDDPFVSRLKIASDTIVYYGMKAHAHEFEQSTMNESRYCPNCGRLLQYDYIHYNQIGHYHCQCGFKREQAKYEISRFDVAPFLHLNINDEKYDMKIAGDFNAYNALAAYTVLRELGLNEQAIKNGFETYTSDNGRMQYFKKERKEAMINLAKNPAGMNASLSVGEQLEGEKVYVISLNDNAADGRDTSWIYDADFEKLSKQQIEAIIVTGTRAEELQLRLKLAEVEVPIIVERDIYKATAKTMDYKGFTVAIPNYTSLAPMLEQLNRSFEGGQS
>NC_022113.1|WP_000949466.1|1927719_1928220_+|H-type-ferritin-FtnA
MLSKNLLEALNDQMNHEYFAAHAYMAMAAYCDKESYEGFANFFIQQAKEERFHGQKIYNYINDRGAHAEFRAVSAPKIDFSSILETFKDSLSQEQEVTRRFYNLSEIARQDKDYATISFLNWFLDEQVEEEAMFETHINYLTRIGDDSNALYLYEKELGTRTFDEE
>NC_022113.1|WP_001790679.1|1928301_1928394_-|hypothetical-protein
MTKNTIISLENEKTQINDSENESSDLRKAK
>NC_022113.1|WP_000613738.1|1928610_1929165_+|3'-5'-exonuclease
MIQDAFVALDFETANGKRTSICSVGMVKVIDSQITETFHTLVNPQDYFSQQNIKVHGIQPEDVENAPTFDYVFPYMMQFIADLPVVAHNAAFDMNVLHQSIQNIGLPTPNLTYFCSYQLAKRTVDSYRYGLKHMMEFYQLDFHGHHDALNDAKACAMITFRLLKNYENLTYVTNIYGKNLKDKG
>NC_022113.1|WP_000140179.1|1929231_1930302_-|DNA-polymerase-IV
MTERRIIHIDMDYFFAQVEMRDNPKLKGKPVIVGGKASSRGVVSTASYEARKYGVHSAMPMSQAHKLCPNGYFVTSNFGAYRETSAQIMSIFRSYTDKVEPMSLDEAYLDITELVRPDLPASKIAQYIRKDILEQTHLTASAGVSYNKFLAKLASGMNKPDGMTVIDYRNVHDILMTLDIGDFPGVGKASKKVMHDNGIFNGRDLYEKTEFELIRLFGKRGRGLYNKARGIDHSEVKSTRVRKSVGTERTFATDVNDDEEILRKVWELSGKTAERLNKLQKSAKTVTVKIKTYQFETLSKQMSLRDSVSSEEDIYNIAYLLYNDLKDPDVPIRLIGVTVGNLEQSTYKNMTIYDFI
>NC_022113.1|WP_000548777.1|1930548_1931079_-|DUF3267-domain-containing-protein
MHKIDLTTNNFQMRRFIILQLVIALFVILFTYKWALGVTAVVDQNIIINLVYGFAGFIILLILHELIHRALFLLFKKDSKPMFNIKKDRILFQTADACFNKWQFSIIMLSPLILLSAGLLILIKVFGYSSLIFMFSMHTAYCFIDILLVALTISSSFKYVQQDEDSIYLYHQKPTQ

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Crispr_ID: NC_022113_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022113_9

1933780-1933971

Orphan

Consensus_repeat	Method
NNTCTNTGTTGGGGCCCNCACC	CRT

3 spacers

DEDDh

The CRISPR arrays of NC_022113_9

>merge|NC_022113|9|1933780-1933971|CRT
CTCTATGTTTGGGGCCCCACCCCAACTTGCACATTATTGTAAGCTGACAGAAAGTCAGCTTCTATGTTGGGGCCCCGCCAACTTGCATTGTCTGTAGAATTTCCTTTCGAAATTCTCTTTGTTGGGGCCCCACCCTAACTTGCACATTATTGTAAGCTGACAGAAAGTCAGCTTCTTTGTTGGGGCCCCACT

>NC_022113|9|1|1933780-1933971|CRT
CTCTATGTTTGGGGCCCCACC	CCAACTTGCACATTATTGTAAGCTGACAGAAAGTCAG
CTTCTATGTTGGGGCCCCGCC	AACTTGCATTGTCTGTAGAATTTCCTTTCGAAAT
TCTCTTTGTTGGGGCCCCACC	CTAACTTGCACATTATTGTAAGCTGACAGAAAGTCAG
CTTCTTTGTTGGGGCCCCACT

Protein	Signature genes	Signature genes Name	Protein_function
NC_022113.1\|WP_001147874.1\|1931248_1932610_-\|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD	unknown	unknown	gnl\|CDD\|225174
NC_022113.1\|WP_000548777.1\|1930548_1931079_-\|DUF3267-domain-containing-protein	unknown	unknown	gnl\|CDD\|378690
NC_022113.1\|WP_000027924.1\|1935900_1937358_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA	unknown	unknown	gnl\|CDD\|234572
NC_022113.1\|WP_000544973.1\|1925381_1926113_-\|type-1-glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|225974
NC_022113.1\|WP_000140179.1\|1929231_1930302_-\|DNA-polymerase-IV	unknown	unknown	gnl\|CDD\|235035
NC_022113.1\|WP_000957023.1\|1938028_1939567_+\|sodium/proline-symporter-PutP	unknown	unknown	gnl\|CDD\|273981
NC_022113.1\|WP_000613738.1\|1928610_1929165_+\|3'-5'-exonuclease	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|99834
NC_022113.1\|WP_001790257.1\|1925185_1925296_-\|hypothetical-protein	unknown	unknown	unknown
NC_022113.1\|WP_001791535.1\|1934275_1934422_-\|hypothetical-protein	unknown	unknown	unknown
NC_022113.1\|WP_001250339.1\|1926114_1927428_-\|lipid-II-isoglutaminyl-synthase-subunit-MurT	unknown	unknown	gnl\|CDD\|223840
NC_022113.1\|WP_000992924.1\|1942874_1945067_-\|DNA-helicase-PcrA	unknown	unknown	gnl\|CDD\|273429
NC_022113.1\|WP_000170162.1\|1937359_1937662_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC	unknown	unknown	gnl\|CDD\|178810
NC_022113.1\|WP_000272063.1\|1945063_1945756_-\|heptaprenylglyceryl-phosphate-synthase	unknown	unknown	gnl\|CDD\|224560
NC_022113.1\|WP_001231458.1\|1932690_1933638_-\|diacylglycerol-kinase	unknown	unknown	gnl\|CDD\|183982
NC_022113.1\|WP_000774552.1\|1940867_1942871_-\|NAD-dependent-DNA-ligase-LigA	unknown	unknown	gnl\|CDD\|236137
NC_022113.1\|WP_000949466.1\|1927719_1928220_+\|H-type-ferritin-FtnA	unknown	unknown	gnl\|CDD\|224445
NC_022113.1\|WP_000831695.1\|1939655_1940855_-\|CamS-family-sex-pheromone-protein	unknown	unknown	gnl\|CDD\|227188
NC_022113.1\|WP_001790679.1\|1928301_1928394_-\|hypothetical-protein	unknown	unknown	unknown
NC_022113.1\|WP_001165363.1\|1945938_1946241_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226893
NC_022113.1\|WP_000545372.1\|1934460_1935888_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB	unknown	unknown	gnl\|CDD\|235489

Protein	Function_ID	Function_description	E-value
NC_022113.1\|WP_001147874.1\|1931248_1932610_-\|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD	gnl\|CDD\|225174	COG2265, TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis].	0
NC_022113.1\|WP_000548777.1\|1930548_1931079_-\|DUF3267-domain-containing-protein	gnl\|CDD\|378690	pfam11667, DUF3267, Putative zincin peptidase. This family of proteins has a conserved HEXXH motif, suggesting the members are putative peptidases of zincin fold.	1.54005e-11
NC_022113.1\|WP_000027924.1\|1935900_1937358_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA	gnl\|CDD\|234572	PRK00012, gatA, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA.	0
NC_022113.1\|WP_000544973.1\|1925381_1926113_-\|type-1-glutamine-amidotransferase	gnl\|CDD\|225974	COG3442, COG3442, Predicted glutamine amidotransferase [General function prediction only].	1.79354e-120
NC_022113.1\|WP_000170162.1\|1937359_1937662_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC	gnl\|CDD\|178810	PRK00034, gatC, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC.	5.296e-34
NC_022113.1\|WP_000957023.1\|1938028_1939567_+\|sodium/proline-symporter-PutP	gnl\|CDD\|273981	TIGR02121, Osmoregulated_proline_transporter, sodium/proline symporter. This family consists of the sodium/proline symporter (proline permease) from a number of Gram-negative and Gram-positive bacteria and from the archaeal genus Methanosarcina. Using the related pantothenate permease as an outgroup, candidate sequences from Bifidobacterium longum and several from archaea are found to be outside the clade defined by known proline permeases. These sequences, scoring between 570 and -40, define the range between trusted and noise cutoff scores. [Transport and binding proteins, Amino acids, peptides and amines].	0
NC_022113.1\|WP_000613738.1\|1928610_1929165_+\|3'-5'-exonuclease	gnl\|CDD\|99834	cd06130, DNA_pol_III_epsilon_like, an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III. This subfamily is composed of uncharacterized bacterial proteins with similarity to the epsilon subunit of DNA polymerase III (Pol III), a multisubunit polymerase which is the main DNA replicating enzyme in bacteria, functioning as the chromosomal replicase. The Pol III holoenzyme is a complex of ten different subunits, three of which (alpha, epsilon, and theta) compose the catalytic core. The Pol III epsilon subunit, encoded by the dnaQ gene, is a DEDDh-type 3'-5' exonuclease which is responsible for the proofreading activity of the polymerase, increasing the fidelity of DNA synthesis. It contains three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. The epsilon subunit of Pol III also functions as a stabilizer of the holoenzyme complex.	4.39188e-75
NC_022113.1\|WP_000992924.1\|1942874_1945067_-\|DNA-helicase-PcrA	gnl\|CDD\|273429	TIGR01073, ATP-dependent_DNA_helicase_PcrA, ATP-dependent DNA helicase PcrA. Designed to identify pcrA members of the uvrD/rep subfamily. [DNA metabolism, DNA replication, recombination, and repair].	0
NC_022113.1\|WP_001250339.1\|1926114_1927428_-\|lipid-II-isoglutaminyl-synthase-subunit-MurT	gnl\|CDD\|223840	COG0769, MurE, UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane].	3.60835e-98
NC_022113.1\|WP_000140179.1\|1929231_1930302_-\|DNA-polymerase-IV	gnl\|CDD\|235035	PRK02406, PRK02406, DNA polymerase IV; Validated.	0
NC_022113.1\|WP_000272063.1\|1945063_1945756_-\|heptaprenylglyceryl-phosphate-synthase	gnl\|CDD\|224560	COG1646, COG1646, Predicted phosphate-binding enzymes, TIM-barrel fold [General function prediction only].	2.53994e-99
NC_022113.1\|WP_001231458.1\|1932690_1933638_-\|diacylglycerol-kinase	gnl\|CDD\|183982	PRK13337, PRK13337, putative lipid kinase; Reviewed.	0
NC_022113.1\|WP_000774552.1\|1940867_1942871_-\|NAD-dependent-DNA-ligase-LigA	gnl\|CDD\|236137	PRK07956, ligA, NAD-dependent DNA ligase LigA; Validated.	0
NC_022113.1\|WP_000949466.1\|1927719_1928220_+\|H-type-ferritin-FtnA	gnl\|CDD\|224445	COG1528, Ftn, Ferritin-like protein [Inorganic ion transport and metabolism].	1.15329e-74
NC_022113.1\|WP_000831695.1\|1939655_1940855_-\|CamS-family-sex-pheromone-protein	gnl\|CDD\|227188	COG4851, CamS, Protein involved in sex pheromone biosynthesis [General function prediction only].	0
NC_022113.1\|WP_001165363.1\|1945938_1946241_-\|hypothetical-protein	gnl\|CDD\|226893	COG4496, COG4496, Uncharacterized protein conserved in bacteria [Function unknown].	1.66593e-59
NC_022113.1\|WP_000545372.1\|1934460_1935888_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB	gnl\|CDD\|235489	PRK05477, gatB, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB.	0

>NC_022113.1|WP_001231458.1|1932690_1933638_-|diacylglycerol-kinase
MRKRARIIYNPTSGKEQFKRELPDALIKLEKAGYETSAYATEKIGDATLEAERAMHENYDVLIAAGGDGTLNEVVNGIAEKPNRPKLGVIPMGTVNDFGRALHIPNDIMGALDVIIEGHSTKVDIGKMNNRYFINLAAGGQLTQVSYETPSKLKSIVGPFAYYIKGFEMLPQMKAVDLRIEYDGNVFQGEALLFFLGLTNSMAGFEKLVPDAKLDDGYFTLIIVEKSNLAELGHIMTLASRGEHTKHPKVIYEKAKAINISSFTDLQLNVDGEYGGKLPANFLNLERHIDVFAPNDIVNEELINNDHVDDNLIEE
>NC_022113.1|WP_001147874.1|1931248_1932610_-|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD
MQAIAKNDIKTGTVVDLTHEGHGVVKIDRFPIFIPQALINEQIEYKIIKVKKNFAIGKLLNINTRSENRVAPPCIYYERCGGCQLQHLSYEAQLEMKKEQVINLFQRKAHFDNSKINDTVGMTDPWRYRNKSQIPVGKNEQNEVIMGFYRQRSHDIIDMGSCLIQDSQHQEVMNEVKSILKDLNVSIYQEQLKKGLMRHLVVRTGYHTDEMMVIFVTNGKNWPQKNAVVEKILDAFPNVTSIKQNINDSHSNVIMGRQSITLYGKDTIIDQLTDSTFKISDQSFYQINSEQTEKLYNKAIEYAQLTGNEVVLDTYCGIGTIGLYMAPHAKHVYGVEVVPSAIEDAQQNATINQCNNTTFVCGKAEEVILQWKAQGIKPDVVMVDPPRKGCDETFIQTLLTLEPKRIVYISCNPSTQQRDALLLAEKYQLEEVTPVDMFPQTTHVETVALFNLK
>NC_022113.1|WP_000548777.1|1930548_1931079_-|DUF3267-domain-containing-protein
MHKIDLTTNNFQMRRFIILQLVIALFVILFTYKWALGVTAVVDQNIIINLVYGFAGFIILLILHELIHRALFLLFKKDSKPMFNIKKDRILFQTADACFNKWQFSIIMLSPLILLSAGLLILIKVFGYSSLIFMFSMHTAYCFIDILLVALTISSSFKYVQQDEDSIYLYHQKPTQ
>NC_022113.1|WP_000140179.1|1929231_1930302_-|DNA-polymerase-IV
MTERRIIHIDMDYFFAQVEMRDNPKLKGKPVIVGGKASSRGVVSTASYEARKYGVHSAMPMSQAHKLCPNGYFVTSNFGAYRETSAQIMSIFRSYTDKVEPMSLDEAYLDITELVRPDLPASKIAQYIRKDILEQTHLTASAGVSYNKFLAKLASGMNKPDGMTVIDYRNVHDILMTLDIGDFPGVGKASKKVMHDNGIFNGRDLYEKTEFELIRLFGKRGRGLYNKARGIDHSEVKSTRVRKSVGTERTFATDVNDDEEILRKVWELSGKTAERLNKLQKSAKTVTVKIKTYQFETLSKQMSLRDSVSSEEDIYNIAYLLYNDLKDPDVPIRLIGVTVGNLEQSTYKNMTIYDFI
>NC_022113.1|WP_000613738.1|1928610_1929165_+|3'-5'-exonuclease
MIQDAFVALDFETANGKRTSICSVGMVKVIDSQITETFHTLVNPQDYFSQQNIKVHGIQPEDVENAPTFDYVFPYMMQFIADLPVVAHNAAFDMNVLHQSIQNIGLPTPNLTYFCSYQLAKRTVDSYRYGLKHMMEFYQLDFHGHHDALNDAKACAMITFRLLKNYENLTYVTNIYGKNLKDKG
>NC_022113.1|WP_001790679.1|1928301_1928394_-|hypothetical-protein
MTKNTIISLENEKTQINDSENESSDLRKAK
>NC_022113.1|WP_000949466.1|1927719_1928220_+|H-type-ferritin-FtnA
MLSKNLLEALNDQMNHEYFAAHAYMAMAAYCDKESYEGFANFFIQQAKEERFHGQKIYNYINDRGAHAEFRAVSAPKIDFSSILETFKDSLSQEQEVTRRFYNLSEIARQDKDYATISFLNWFLDEQVEEEAMFETHINYLTRIGDDSNALYLYEKELGTRTFDEE
>NC_022113.1|WP_001250339.1|1926114_1927428_-|lipid-II-isoglutaminyl-synthase-subunit-MurT
MRQWTAIHLAKLARKASRAVGKRGTDLPGQIARKVDTDILRKLAEQVDDIVFISGTNGKTTTSNLIGHTLKANNIQIIHNNEGANMAAGITSAFIMQSTPKTKIAVIEIDEGSIPRVLKEVTPSMMVFTNFFRDQMDRFGEIDIMVNNIAETISNKGIKLLLNGDDPFVSRLKIASDTIVYYGMKAHAHEFEQSTMNESRYCPNCGRLLQYDYIHYNQIGHYHCQCGFKREQAKYEISRFDVAPFLHLNINDEKYDMKIAGDFNAYNALAAYTVLRELGLNEQAIKNGFETYTSDNGRMQYFKKERKEAMINLAKNPAGMNASLSVGEQLEGEKVYVISLNDNAADGRDTSWIYDADFEKLSKQQIEAIIVTGTRAEELQLRLKLAEVEVPIIVERDIYKATAKTMDYKGFTVAIPNYTSLAPMLEQLNRSFEGGQS
>NC_022113.1|WP_000544973.1|1925381_1926113_-|type-1-glutamine-amidotransferase
MHELTIYHFMSDKLNLYSDIGNIIALRQRAKKRNIKVNVVEINETEGITFDECDIFFIGGGSDREQALATKELSKIKTPLKEAIEDGMPGLTICGGYQFLGKKYITPDGTELEGLGILDFYTESKTNRLTGDIVIESDTFGTIVGFENHGGRTYHNFGTLGHVTFGYGNNDEDKKEGIHYKNLLGTYLHGPILPKNYEITDYLLEKACERKGIPFEPKEIDNEAEKQAKQVLIDRANRQKKSR
>NC_022113.1|WP_001790257.1|1925185_1925296_-|hypothetical-protein
MDGNNQIDVCFFVLVNNYYTMSIYPRIINSNGDYAT
>NC_022113.1|WP_001791535.1|1934275_1934422_-|hypothetical-protein
MVADLDAIEGLFISIEVILLLTLFIVHVNGKNINFINALALIILRQTV
>NC_022113.1|WP_000545372.1|1934460_1935888_-|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB
MHFETVIGLEVHVELKTDSKMFSPSPAHFGAEPNSNTNVIDLAYPGVLPVVNKRAVDWAMRAAMALNMEIATESKFDRKNYFYPDNPKAYQISQFDQPIGENGYIDIEVDGETKRIGITRLHMEEDAGKSTHKGEYSLVDLNRQGTPLIEIVSEPDIRSPKEAYAYLEKLRSIIQYTGVSDVKMEEGSLRCDANISLRPYGQEKFGTKAELKNLNSFNYVRKGLEYEEKRQEEELLSGGEIGQETRRFDESTGKTILMRVKEGSDDYRYFPEPDIVPLYIDDAWKERVRQTIPELPDERKAKYVNELGLPAYDAHVLTLTKEMSDFFESTIEHGADVKLTSNWLMGGVNEYLNKNQVELLDIKLTPENLAGMIKLIEDGTMSSKIAKKVFPELAAKGGNAKQIMEDNGLVQISDEATLLKFVNEALDNNEQSVEDYKNGKGKAMGFLVGQIMKASKGQANPQLVNQLLKQELDKR
>NC_022113.1|WP_000027924.1|1935900_1937358_-|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA
MSIRYESVENLLTLIKDKKIKPSDVVKDIYDAIEETDPTIKSFLALDKENAIKKAQELDELQAKDQMDGKLFGIPMGIKDNIITNGLETTCASKMLEGFVPIYESTVMEKLHNENAVLIGKLNMDEFAMGGSTETSYFKKTVNPFDHKAVPGGSSGGSAAAVAAGLVPFSLGSDTGGSIRQPAAYCGVVGMKPTYGRVSRFGLVAFASSLDQIGPLTRNVKDNAIVLEAISGADANDSTSAPVDDVDFTSEIGKDIKGLKVALPKEYLGEGVADDVKEAVQNAVETLKSLGAVVEEVSLPNTKFGIPSYYVIASSEASSNLSRFDGIRYGYHSKEAHSLEELYKMSRSEGFGKEVKRRIFLGTFALSSGYYDAYYKKSQKVRTLIKNDFDKVFENYDVVVGPTAPTTAFNLGEEIDDPLTMYANDLLTTPVNLAGLPGISVPCGQSNGRPIGLQFIGKPFDEKTLYRVAYQYETQYNLHDVYEKL
>NC_022113.1|WP_000170162.1|1937359_1937662_-|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC
MTKVTREEVEHIANLARLQISPEETEEMANTLESILDFAKQNDSADTEGVEPTYHVLDLQNVLREDKAIKGIPQELALKNAKETEDGQFKVPTIMNEEDA
>NC_022113.1|WP_000957023.1|1938028_1939567_+|sodium/proline-symporter-PutP
MLTMGTALSQQVDANWQTYIMIAVYFLILIVIGFYGYKQATGNLSEYMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGLSAMWITIGLTLGAYINYFVVAPRLRVYTELAGDAITLPDFFKNRLNDKNNVLKIISGLIIVVFFTLYTHSGFVSGGKLFESAFGLDYHFGLILVAFIVIFYTFFGGYLAVSITDFFQGVIMLIAMVMVPIVAMMNLNGWGTFHDVAAMKPTNLNLFKGLSFIGIISLFSWGLGYFGQPHIIVRFMSIKSHKMLPKARRLGISWMAVGLLGAVAVGLTGIAFVPAYHIKLEDPETLFIVMSQVLFHPLVGGFLLAAILAAIMSTISSQLLVTSSSLTEDFYKLVRGEEKAKTHQKEFVMVGRLSVLAVAIVAIAIAWNPNDTILNLVGNAWAGFGASFSPLVLFALYWKGLTRAGAVSGMVSGALVVIVWIAWIKPLAHINEIFGLYEIIPGFIVSVIVTYVVSKLTKKPGAFVETDLNKVRDIVREK
>NC_022113.1|WP_000831695.1|1939655_1940855_-|CamS-family-sex-pheromone-protein
MKRTLVLLITAIFILAACGNHKDDQAGKDNQKHNNSSNQVKEIATDKNVQGDNYRTLLPFKESQARGLLQDNMANSYNGGDFEDGLLNLSKEVFPTDKYLYQDGQFLDKKTINAYLNPKYTKREIDKMSEKDKKDKKANENLGLNPSHEGETDPEKIAEKSPAYLSNILEQDFYGGGDTKGKNIKGMTIGLAMNSVYYYKKEKDGPTFSKKLDDSEVKKQGKQMASEILSRLRENDDLKDIPIHFAIYKQSSEDSITPGEFITQATAEKSQTKLNEWHNINEKSALLPSSTAADYDENLNNNFKQFNDNLQSYFSNFTQAVGKVKFVDKKPQRLVVDLPIDYYGQAETIGITQYVTEQANKYFDKIDNYEIRIKDGNQPRALISKTKDDKEPQVHIYSN
>NC_022113.1|WP_000774552.1|1940867_1942871_-|NAD-dependent-DNA-ligase-LigA
MADLSSRVNELHDLLNQYSYEYYVEDNPSVPDSEYDKLLHELIKIEEEHPEFKTVDSPTVRVGGEAQASFNKVNHDTPMLSLGNAFNEDDLRKFDQRIREQIGNVEYMCELKIDGLAVSLKYVDGYFVQGLTRGDGTTGEDITENLKTIHAIPLKMKEPLNVEVRGEAYMPRRSFLRLNEEKEKNDEQLFANPRNAAAGSLRQLDSKLTAKRKLSVFIYSVNDFTDFNARSQSEALDELDKLGFTTNKNRARVSDIDGVLEYIEKWTSQRESLPYDIDGIVIKVNDLDQQDEMGFTQKSPRWAIAYKFPAEEVVTKLLDIELSIGRTGVVTPTAILEPVKVAGTTVSRASLHNEDLIHDRDIRIGDSVVVKKAGDIIPEVVRSIPERRPEDAVTYHMPTHCPSCGHELVRIEGEVALRCINPKCQAQLVEGLIHFVSRQAMNIDGLGTKIIQQLYQSELIKDVADIFYLTEEDLLPLDRMGQKKVDNLLAAIQQAKDNSLENLLFGLGIRHLGVKASQVLAEKYETIDRLLTVTEAELVEIHDIGDKVAQSVVTYLENEDIRALIQKLKDKHVNMIYKGIKTSDIEGHPEFSGKTIVLTGKLHQMTRNEASKWLASQGAKVTSSVTKNTDVVIAGEDAGSKLTKAQSLGIEIWTEQQFVDKQNELNS
>NC_022113.1|WP_000992924.1|1942874_1945067_-|DNA-helicase-PcrA
MNALLNHMNTEQSEAVKTTEGPLLIMAGAGSGKTRVLTHRIAYLLDEKDVSPYNVLAITFTNKAAREMKERVQKLVGDQAEVIWMSTFHSMCVRILRRDADRIGIERNFTIIDPTDQKSVIKDVLKNENIDSKKFEPRMFIGAISNLKNELKTPADAQKEATDYHSQMVATVYSGYQRQLSRNEALDFDDLIMTTINLFERVPEVLEYYQNKFQYIHVDEYQDTNKAQYTLVKLLASKFKNLCVVGDSDQSIYGWRGADIQNILSFEKDYPEANTIFLEQNYRSTKTILNAANEVIKNNSERKPKGLWTANTNGEKIHYYEAMTERDEAEFVIREIMKHQRNGKKYQDMAILYRTNAQSRVLEETFMKSNMPYTMVGGQKFYDRKEIKDLLSYLRIIANSNDDISLQRIINVPKRGVGPSSVEKVQNYALQNNISMFDALGEADFIGLSKKVTQECLNFYELIQSLIKEQEFLEIHEIVDEVLQKSGYREMLERENTLESRSRLENIDEFMSVPKDYEENTPLEEQSLINFLTDLSLVADIDEADTENGVTLMTMHSAKGLEFPIVFIMGMEESLFPHIRAIKSEDDHEMQEERRICYVAITRAEEVLYITHATSRMLFGRPQSNMPSRFLKEIPESLLENHSSGKRQTIQPKAKPFAKRGFSQRTTSTKKQVSSSDWNVGDKVMHKAWGEGMVSNVNEKNGSIELDIIFKSQGPKRLLAQFAPIEKKED
>NC_022113.1|WP_000272063.1|1945063_1945756_-|heptaprenylglyceryl-phosphate-synthase
MYDIKKWRHIFKLDPAKHISDDDLDAICMSQTDAIMIGGTDDVTEDNVIHLMSRVRRYPLPLVLEISNIESVMPGFDFYFVPTVLNSTDVAFHNGTLLEALKTYGHSIDFEEVIFEGYVVCNADSKVAKHTKANTDLTTEDLEAYAQMVNHLYRLPVMYIEYSGIYGDVSKVQAVSEHLTETQLFYGGGISSEQQATEMAAIADTIIVGDIIYKDIKKALKTVKIKESSK
>NC_022113.1|WP_001165363.1|1945938_1946241_-|hypothetical-protein
MQIEKLRGAALDELFDAILTLENREECYQFFDDLCTVNEIQSLSQRLQVAKMIKQGYTYATIEQESGASTATISRVKRSLQWGNDAYTMILDRMNIETNE

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Crispr_ID: NC_022113_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022113_10

2158915-2159004

Orphan

Consensus_repeat	Method
CAACTTTAGTTGTTAGGGGCTCTT	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NC_022113_10

>merge|NC_022113|10|2158915-2159004|CRISPRCasFinder
CAACTTTAGTTGTTAGGGGCTCTTATGCAGTTGATGCGCAGCATCCAACTGTGTTCCTCTATTTTTCAACTTTAGTTGTTAGGGGCTTCT

>NC_022113|10|9|2158915-2159004|CRISPRCasFinder
CAACTTTAGTTGTTAGGGGCTCTT	ATGCAGTTGATGCGCAGCATCCAACTGTGTTCCTCTATTTTT
CAACTTTAGTTGTTAGGGGCTTCT

Protein	Signature genes	Signature genes Name	Protein_function
NC_022113.1\|WP_000908186.1\|2161865_2162648_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224044
NC_022113.1\|WP_001024099.1\|2155421_2156087_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187554
NC_022113.1\|WP_000123402.1\|2151740_2153114_-\|EVE-domain-containing-protein	unknown	unknown	gnl\|CDD\|376640
NC_022113.1\|WP_073392962.1\|2159339_2159444_-\|hypothetical-protein	unknown	unknown	unknown
NC_022113.1\|WP_000334466.1\|2162879_2164685_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	unknown	unknown	gnl\|CDD\|234729
NC_022113.1\|WP_001292150.1\|2169082_2169517_+\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|227014
NC_022113.1\|WP_001127959.1\|2154047_2154986_-\|class-I-mannose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|224399
NC_022113.1\|WP_001792784.1\|2160123_2160282_+\|hypothetical-protein	unknown	unknown	unknown
NC_022113.1\|WP_000083795.1\|2165365_2166904_+\|PTS-mannitol-transporter-subunit-IICB	unknown	unknown	gnl\|CDD\|225123
NC_022113.1\|WP_001123310.1\|2150878_2151292_-\|thiol-disulfide-oxidoreductase-DCC-family-protein	unknown	unknown	gnl\|CDD\|225556
NC_022113.1\|WP_000648736.1\|2169516_2170623_+\|mannitol-1-phosphate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|235031
NC_022113.1\|WP_000521495.1\|2178618_2179974_-\|phosphoglucosamine-mutase	unknown	unknown	gnl\|CDD\|237670
NC_022113.1\|WP_000019741.1\|2156560_2157541_+\|CDF-family-zinc-efflux-transporter-CzrB	unknown	unknown	gnl\|CDD\|224151
NC_022113.1\|WP_000808817.1\|2153786_2154017_-\|hypothetical-protein	unknown	unknown	unknown
NC_022113.1\|WP_000003759.1\|2156238_2156559_+\|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NC_022113.1\|WP_000160304.1\|2149404_2150115_+\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|180275
NC_022113.1\|WP_000927367.1\|2166938_2169071_+\|BglG-family-transcription-antiterminator	unknown	unknown	gnl\|CDD\|226234
NC_022113.1\|WP_000495684.1\|2157806_2158898_+\|hypothetical-protein	unknown	unknown	unknown
NC_022113.1\|WP_000370937.1\|2160940_2161798_-\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|223635
NC_022113.1\|WP_000070866.1\|2150235_2150679_-\|DNA-starvation/stationary-phase-protection-protein	unknown	unknown	gnl\|CDD\|223854

Protein	Function_ID	Function_description	E-value
NC_022113.1\|WP_000908186.1\|2161865_2162648_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224044	COG1119, ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism].	1.75723e-107
NC_022113.1\|WP_001024099.1\|2155421_2156087_-\|SDR-family-oxidoreductase	gnl\|CDD\|187554	cd05243, SDR_a5, atypical (a) SDRs, subgroup 5. This subgroup contains atypical SDRs, some of which are identified as putative NAD(P)-dependent epimerases, one as a putative NAD-dependent epimerase/dehydratase. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine-rich NAD(P)-binding motif that is very similar to the extended SDRs, GXXGXXG, and binds NADP. Generally, this subgroup has poor conservation of the active site tetrad; however, individual sequences do contain matches to the YXXXK active site motif, the upstream Ser, and there is a highly conserved Asp in place of the usual active site Asn throughout the subgroup. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	7.27205e-48
NC_022113.1\|WP_000123402.1\|2151740_2153114_-\|EVE-domain-containing-protein	gnl\|CDD\|376640	pfam01878, EVE, EVE domain. This domain was formerly known as DUF55. Crystal structures have shown that this domain is part of the PUA superfamily. This domain has been named EVE and is thought to be RNA-binding.	3.86989e-06
NC_022113.1\|WP_000070866.1\|2150235_2150679_-\|DNA-starvation/stationary-phase-protection-protein	gnl\|CDD\|223854	COG0783, Dps, DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism].	1.22744e-67
NC_022113.1\|WP_000334466.1\|2162879_2164685_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	gnl\|CDD\|234729	PRK00331, PRK00331, isomerizing glutamine--fructose-6-phosphate transaminase.	0
NC_022113.1\|WP_001292150.1\|2169082_2169517_+\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|227014	COG4668, MtlA, Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and metabolism].	6.01856e-62
NC_022113.1\|WP_001127959.1\|2154047_2154986_-\|class-I-mannose-6-phosphate-isomerase	gnl\|CDD\|224399	COG1482, ManA, Phosphomannose isomerase [Carbohydrate transport and metabolism].	7.00589e-128
NC_022113.1\|WP_000083795.1\|2165365_2166904_+\|PTS-mannitol-transporter-subunit-IICB	gnl\|CDD\|225123	COG2213, MtlA, Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism].	0
NC_022113.1\|WP_001123310.1\|2150878_2151292_-\|thiol-disulfide-oxidoreductase-DCC-family-protein	gnl\|CDD\|225556	COG3011, COG3011, Predicted thiol-disulfide oxidoreductase [General function prediction only].	4.7919e-46
NC_022113.1\|WP_000648736.1\|2169516_2170623_+\|mannitol-1-phosphate-5-dehydrogenase	gnl\|CDD\|235031	PRK02318, PRK02318, mannitol-1-phosphate 5-dehydrogenase; Provisional.	0
NC_022113.1\|WP_000521495.1\|2178618_2179974_-\|phosphoglucosamine-mutase	gnl\|CDD\|237670	PRK14316, glmM, phosphoglucosamine mutase; Provisional.	0
NC_022113.1\|WP_000019741.1\|2156560_2157541_+\|CDF-family-zinc-efflux-transporter-CzrB	gnl\|CDD\|224151	COG1230, CzcD, Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism].	4.09175e-108
NC_022113.1\|WP_000003759.1\|2156238_2156559_+\|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	1.8473e-17
NC_022113.1\|WP_000160304.1\|2149404_2150115_+\|purine-nucleoside-phosphorylase	gnl\|CDD\|180275	PRK05819, deoD, DeoD-type purine-nucleoside phosphorylase.	2.10672e-157
NC_022113.1\|WP_000927367.1\|2166938_2169071_+\|BglG-family-transcription-antiterminator	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	9.39374e-67
NC_022113.1\|WP_000370937.1\|2160940_2161798_-\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|223635	COG0561, Cof, Predicted hydrolases of the HAD superfamily [General function prediction only].	1.15818e-59

>NC_022113.1|WP_000495684.1|2157806_2158898_+|hypothetical-protein
MFTYFKSAFKNAKPQLLITLIYALIAFAVIAVVYLLANFQLAKYVQTIAIYSQFGQKPPVDAYLKVIAVLLIAAVVSLFVLVQIFIGITNVMKRAMSHEKVKFTDLFIAFKKGNYLKSVLIGLVSIAMIIVLSLLTSLLYKLFSPVSEMIMNSVQSSYADSTHLVGIAITTQSIIIIVVLLIKAIITWLLLIPIFNFMTSFVESTNDKVKTHLANGFKAMKNGQKTFFKFFIGILLLNLVIILFKTPVGYLISFNTQSLSQSVAENIIRVYTVITIILFVVIHAVILMGIVQYYLKRGQKITKDKVKTADKNKKVVTEPKNTKVENDKVTTSVETKTEKAQDSLNDNTTKTMTSDKPEDNQPK
>NC_022113.1|WP_000019741.1|2156560_2157541_+|CDF-family-zinc-efflux-transporter-CzrB
MSHSHHHHDHMHSHVTTNNKKVLFISFLIIGLYMFIEIIGGLLANSLALLSDGIHMFSDTFSLGVALIAFIYAEKNATTTKTFGYKRFEVLAALFNGVTLFVISILIVFEAIKRFFVPSEVQSKEMLIISIIGLIVNIVVAFFMFKGGDTSHNLNMRGAFLHVIGDLLGSVGAITAAILIWAFGWTIADPIASILVSVIILKSAWGITKSSINILMEGTPSDVDIDEVIATIKKDSRIQSVHDCHVWTISNDMNALSCHVVVDHTLTMKECELLLENIEHDLLHLNIHHMTIQLETPNHKHDESIICSGTHSHSHSHHAHHHAHVH
>NC_022113.1|WP_000003759.1|2156238_2156559_+|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA
MSEQYSEINTDTLERVTEIFKALGDYNRIRIMELLSVSEASVGHISHQLNLSQSNVSHQLKLLKSVHLVKAKRQGQSMIYSLDDIHVATMLKQAIHHANHPKESGL
>NC_022113.1|WP_001024099.1|2155421_2156087_-|SDR-family-oxidoreductase
MNILVIGANGGVGSLLVQQLAKENVPFTAGVRQSDQLNALKSQGMKAILVDVENDSIETLTETFKPFDKVIFSVGSGGNTGADKTIIVDLDGAVKSMIASKEANIKHYVMVSTYDSRRQAFDDSGDLKPYTIAKHYADDYLRRSGLNYTILHPGALTNAAGSGKIEAAQYFEGKGEIPREDVATVLKEIVTSNHFNHQEFQIISGDQDIKDALTQFENETD
>NC_022113.1|WP_001127959.1|2154047_2154986_-|class-I-mannose-6-phosphate-isomerase
MPLFLQPILKTKLWGGQRLSEFGYQLDNDTTGECWCVSAHPNGTSEIINGPYQGQTLDRIWSEHRELFGDFPSKDFPLLTKIVDARESLSIHVHPDNSYAFEHENGQYGKSECWYIIDAEEDAEIVIGTLAESREEVANHVQHGTIESILRYIKVKPGEFYFIPAGTVHTISSGILAYETMQSSDITYRLYDFNRQDNQYNGRPLNIEKALDVIQYNAPLPNILPESEIIENHKCTHIVSNDFFTLVKWEISGTLNYMKPREFCLVTVLEGEGQMIVDGEIFKLTTGTNFILTSEDLDSVFEGDFTLMISYV
>NC_022113.1|WP_000808817.1|2153786_2154017_-|hypothetical-protein
MKQFLYIALVCGVIAGLGAFLHIPQYPSMTIPRIVAILGIISAMLTFKDKQISASLKFSALLINVLPLCGTFVASN
>NC_022113.1|WP_000123402.1|2151740_2153114_-|EVE-domain-containing-protein
MTAETNYFWLNCGYNRWNHNEPLVGQTALFESGAHFNPSQGFRAFKKAKVGDQVIFYQVQTDTGLLGCGEIISVETGAQNKIRVQFRFNEQLKPLTADYLKRSEALEFRMSNMKETLFNQITAEEFDLISGLGKGEIKIPRYFFLAETEEFEPGNQYTIYTHTYNGIKRNGYHFYTQLEEGDNIIFYNRTKNQSVVGIGEVSKHIHEKPPIPGRTNSTVIEVSYEKDITPITLSTLNKHPKLKNLYFLQENAKQAIASMSQAQYDAIIEMSDNNGLKSPFEMVQKPDMLESEKEEALKPFILLVVDRKEEGLKAANDLLQKANANPVITTGHPDFSEDMLYGKYLPNETGALYYREGFITQLMPKKDKSYLVIDNFNRIDTDIFQTYINVLEGYEVTLPRYNKDGNMIKWSRQKDSFYYFNPNWHIVGITYDSLEEIKEKYSEQFLKYTRIVKVKHD
>NC_022113.1|WP_001123310.1|2150878_2151292_-|thiol-disulfide-oxidoreductase-DCC-family-protein
MPIVYYDGNCIYCYNYVIWLIQHDLPRNYQFTTLKGEVGQQFFKQHPEAANKNSVILQKGDRIYFESQAIIKLITALPNRTKLLGVGLWLVPKPVRNFGYRMFADNRNRMWKTTWHQPNDYEKSFFLDDNAKVKLTD
>NC_022113.1|WP_000070866.1|2150235_2150679_-|DNA-starvation/stationary-phase-protection-protein
MSNQQDVVKELNQQVANWTVAYTKLHNFHWYVKGPNFFSLHVKFEELYNEASQYVDELAERILAVGGNPVGTLTECLEQSIVKEAAKGYSAEQMVEELSQDFTNISKQLENAIEIAGNAGDDVSEDMFIGMQTSVDKHNWMFKSYLS
>NC_022113.1|WP_000160304.1|2149404_2150115_+|purine-nucleoside-phosphorylase
MTKGTPHIQPNGVKIAKTVLMPGDPLRAKYIADNFLENVEQFNDVRNMFGYTGTYKGKEVSVMGSGMGIPSIGIYSYELYNFFDVDTIIRIGSCGALQENVNLYDVIIAQAASTNSNYVDQYNIPGHFAPIADFELVTKAKNVADQIGATTHVGNVLSSDTFYNADPTFNDAWKKMGILGIEMESAGLYLNAIHAGKKALGIFTVSDHILRDEATTPEERQNSFTQMMEIALEIAE
>NC_022113.1|WP_073392962.1|2159339_2159444_-|hypothetical-protein
MLLLERTSMSDFEMLMIVLTIIGLVLISTQDHKK
>NC_022113.1|WP_001792784.1|2160123_2160282_+|hypothetical-protein
MSKSSDALFNSLTQSFELIEGVYNELVTDNLKIVMYKPRKESTSGRINRRFK
>NC_022113.1|WP_000370937.1|2160940_2161798_-|Cof-type-HAD-IIB-family-hydrolase
MDNVKAIFLDMDGTILHENNQASTYTKDVINRLREKGYKVFLATGRSHSEIHQLVPEDFAVNGIISSNGTIGEVDGEIIFKHGLSLAQVQQIINLAKRQQIYYEVFPFEGNRVSLKEDETWMRDMIRSQDPINGVSHSEWSSRQDALAGKIDWVTKFPEGEYSKIYLFSSNLEKITAFRDELKQNHVQLQISVSNSSRFNAETMAYQTDKGTGIKEMIEHFGINQKETLVIGDSDNDRAMFEFGHYTVAMKNARPEIQALTSDVTAYTNEEDGAAKYLAKHFLAD
>NC_022113.1|WP_000908186.1|2161865_2162648_-|ABC-transporter-ATP-binding-protein
MLIQLDQVGRMKQGKTILKNISWQINEGDKWILYGLNGAGKTTLLNILNAYEPATTGYVNLFGKMPGKVGYSTETVRQHIGFVSHSLLEKFQEGERVIDVVISGAFKSIGVYQDIDDEVRNEAHQLLKLVGMSAKAQQYIGYLSTGEKQRVMIARALMGQPQVLILDEPAAGLDFIARESLLSILDSLSDSYPTLAMIYVTHFIEEITGNFTKILLLKDGESVQQGLIDDILTSENMSRFFQKNVAVQRWNNRFSMAMLE
>NC_022113.1|WP_000334466.1|2162879_2164685_-|glutamine--fructose-6-phosphate-transaminase-(isomerizing)
MCGIVGYIGYDNAKELLLKGLEKLEYRGYDSAGIAVVNDDNTTVFKEKGRIAELRKVADSSDFDGPVGIGHTRWATHGVPNHENSHPHQSSNGRFTLVHNGVIENYEELKGEYLQGVSFISETDTEVIVQLVEYFSNQGLSTEEAFTKVVSLLHGSYALGLLDAEDKDTIYVAKNKSPLLLGVGEGFNVIASDALAMLQVTSEYKEIHDHEIVIVKKDEVIIKDADGNVVERDSYIAEIDASDAEKGVYAHYMLKEIHEQPAVMRRIIQEYQDAEGNLKIDQDIINDVKEADRIYVIAAGTSYHAGLVGKEFLEKWAGVPTEVHVASEFVYNMPLLSEKPLFVYISQSGETADSRAVLVETNKLGHKSLTITNVAGSTLSREADHTLLLHAGPEIAVASTKAYTAQIAVLSILSQIVAKEHGREADIDLLRELAKVTTAIEAIVDDAPIMEQIATDFLETTRNAFFIGRTIDYNVSLEGALKLKEISYIQAEGFAGGELKHGTIALIEEGTPVVGLATQEKVNLSIRGNVKEVVARGAHPCIISMEGLEKEGDTYVIPHVHELLTPLVSVVTLQLISYYAALHRDLDVDKPRNLAKSVTVE
>NC_022113.1|WP_000083795.1|2165365_2166904_+|PTS-mannitol-transporter-subunit-IICB
MSQTEEKKGIGRRVQAFGSFLSSMIMPNIGAFIAWGFIAAIFIDNGWFPNKDLATLAGPMITYLIPLLIAFSGGRLIYDLRGGIIAATATMGVIVALPDTPMLLGAMIMGPLVGWLMKKTDQLIQPRTPQGFEMLFNNFSAGILGFIMTIAGFKILAPLMKFIMHILSVAVEALVHAHLLPLVSILVEPAKIVFLNNAINHGVFTPLGADQAAKAGQSILYTIESNPGPGLGILLAYMIFGKGTAKATSYGAGIIHFFGGIHEIYFPYVLMRPLLFIAVILGGMTGVATYQATGFGFKSPASPGSFIVYCLNAPRGEFLHMLLGVFLATLVSFVVAALIMKFTKEPKQDLEAATAQMETTKGKKSSVASKLVSSDKNVNTEENASGNVSETSSLDDDPEALLDNYNTEDVDAHNYNNINHVIFACDAGMGSSAMGASMLRNKFKKAGINDITVTNTAINQLPKDAQLVITQKKLTDRAIKQTPNAIHISVDNFLNSPRYEELLNNLKKDDQA
>NC_022113.1|WP_000927367.1|2166938_2169071_+|BglG-family-transcription-antiterminator
MLLSTREKEMIALLIKYHGQYITIHDIAQQLAVSSRTIHRELKGVEAYLTSFSLTLERANKKGLRITGADSDLNDLKQSIAQHQTIDLSVEEQKVIIIYALIQAKEPVKQYSLAQEIGVSVQTLAKMLDDLELDLNKYQLSLSRKRGEGIYLVGTESKKREFLSQLMVNNLNSTSVYSVIENHFVFHSLNQIHKDFVDLERIFNVERLLMDYLSALPYQLTESSYLTLTVHIVLSISRIKNGEYVALNDDIYDSVQNTFEHKVASELADKLGQIYDVTFNLAEIAFITIHLRGAKRKNLNDTSLNNRCEENKIKAFVKKVEMISGMTFADLDTLVDGLTLHLNPAINRLQANIETYNPLTDMIKFKYPRLFENVRLALNDCWPDLIFPESEIAFIVLHFGGSIKNQGNRFLNILVVCSSGMGTSRLLSTRLEQVFSEIERITQASVSDLKSLDLSQYDGIISTVNLDIDSPYLTVNPLLPDSDISYVAQFLNTKSTFQETRDKSSNMIDKDDVHIETKDIDGNTSFENEQTSYLTSVFEKHLSDEKSEQLMHHMRSGLTLLDSVKIVSTEVKQWQTYIADYLYQCDVINDPTSFAELLEQRLIDNPGWILSPYPVAIPHLRDNMIKHPMILITVLEEPLTLPSIQNDNQTIKYMISMFIPDNDFMASLISDLSEFLSLKLESIDTFMENPQELETLLRNKFLERIKKQFI
>NC_022113.1|WP_001292150.1|2169082_2169517_+|PTS-sugar-transporter-subunit-IIA
MSELFSNDNIFLNVNVNSQNEAIEKAGKALVDSGAVTDAYIQAMKDREQVVSTFMGNGLAIPHGTDEAKTNVIHSGLTLLQIPEGVDWDGEVVKVVVGIAGKDGEHLDLLSKIAITFSEEGNVDRIVQAKSAEEIKQVFEEADA
>NC_022113.1|WP_000648736.1|2169516_2170623_+|mannitol-1-phosphate-5-dehydrogenase
MKAVHFGAGNIGRGFIGYILADNNVKVTFADVNEEIINALATGHQYDVILADESKTTTRVNNVAAINSMQPSEELKQAILEADIITTAVGVNILPIIAKSFAPFLKEKTNHVNIVACENAIMATDTLKKAVLDITGPLGNNIHFANSAVDRIVPLQKNENILDVMVEPFYEWVVEKDAWYGPELNHIKYVDDLTPYIERKLLTVNTGHAYLAYAGKFAGKATVLDAVKDSSIEAGLRRVLAETSQYITNEFDFTEAEQAGYVEKIIDRFNNSYLSDEVTRVGRGTLRKIGPKDRIIKPLAYLYNKDLERTGLLNTAALLLKYDDTADQETVEKNNYIKEHGLKAFLSEYAKVDDGLADEIIEAYNSLS
>NC_022113.1|WP_000521495.1|2178618_2179974_-|phosphoglucosamine-mutase
MGKYFGTDGVRGVANQELTPELAFKLGRYGGYVLAHNKGEKHPRVLVGRDTRVSGEMLESALIAGLISIGAEVMRLGIISTPGVAYLTRDMGAELGVMISASHNPVADNGIKFFGSDGFKLSDEQENEIEALLDQENPELPRPVGNDIVHYSDYFEGAQKYLSYLKSTVDVNFEGLKIVLDGANGSTSSLAPFLFGDLEADTETIGCSPDGYNINEKCGSTHPEKLAEKVVETESDFGLAFDGDGDRIIAVDENGQIVDGDQIMFIIGQEMHKNQELNNDMIVSTVMSNLGFYKALEQEGIKSNKTKVGDRYVVEEMRRGNYNLGGEQSGHIVMMDYNTTGDGLLTGIQLASVIKMTGKSLSELAGQMKKYPQSLINVRVTDKYRVEENVDVKEVMTKVEVEMNGEGRILVRPSGTEPLVRVMVEAATDEDAERFAQQIADVVQDKMGLDK

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Crispr_ID: NC_022113_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022113_11

2177929-2178130

Orphan

Consensus_repeat	Method
TCCTTGGTTGGCAGGTGCAGCTGGATGTGCTGTA	PILER-CR

2 spacers

The CRISPR arrays of NC_022113_11

>merge|NC_022113|11|2177929-2178130|PILER-CR
TGCTTGGTTGGCAGGTGCTGCTTGATTTCCAGGTTGTGCTTGTGCAGCGTTATTCGGATCAGCTTGATTACCTTGTCCAGCTGGTTGTGCTGTACCTGCTGCCGGTTGTGCTGCGCCTCCTGCTGGATTAGCCTGTCCACCTTGGTTTGCTGGTTGTGCTGCTGGTTGTCCTTGGTTGGCAGGTGCAGCTGGCTGTGCTGTA

>NC_022113|11|1|2177929-2178130|PILER-CR
TGCTTGGTTGGCAGGTGCTGCTTGATTTCCAGGT	TGTGCTTGTGCAGCGTTATTCGGATCAGCTTGATTACCTTGTCCAGCT
GGTTGTGCTGTACCTGCTGCCGGTTGTGCTGCGC	CTCCTGCTGGATTAGCCTGTCCACCTTGGTTTGCTGGTTGTGCTGCTGGTTGTCCTTGGTTGGCAGGTGCAGCT
GGCTGTGCTGTA

Protein	Signature genes	Signature genes Name	Protein_function
NC_022113.1\|WP_000908186.1\|2161865_2162648_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224044
NC_022113.1\|WP_000162591.1\|2181933_2182842_-\|arginase	unknown	unknown	gnl\|CDD\|212515
NC_022113.1\|WP_073392962.1\|2159339_2159444_-\|hypothetical-protein	unknown	unknown	unknown
NC_022113.1\|WP_000334466.1\|2162879_2164685_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	unknown	unknown	gnl\|CDD\|234729
NC_022113.1\|WP_001237527.1\|2192496_2193840_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NC_022113.1\|WP_000894028.1\|2180000_2180933_-\|YbbR-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|227193
NC_022113.1\|WP_000958522.1\|2189058_2190123_-\|P-loop-NTPase	unknown	unknown	gnl\|CDD\|378455
NC_022113.1\|WP_000047120.1\|2194017_2194701_-\|hemolysin-III-family-protein	unknown	unknown	gnl\|CDD\|224191
NC_022113.1\|WP_001792784.1\|2160123_2160282_+\|hypothetical-protein	unknown	unknown	unknown
NC_022113.1\|WP_000083795.1\|2165365_2166904_+\|PTS-mannitol-transporter-subunit-IICB	unknown	unknown	gnl\|CDD\|225123
NC_022113.1\|WP_000648736.1\|2169516_2170623_+\|mannitol-1-phosphate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|235031
NC_022113.1\|WP_000521495.1\|2178618_2179974_-\|phosphoglucosamine-mutase	unknown	unknown	gnl\|CDD\|237670
NC_022113.1\|WP_072435031.1\|2191901_2192375_-\|multidrug-efflux-transporter-SepA	unknown	unknown	gnl\|CDD\|374975
NC_022113.1\|WP_000347893.1\|2180934_2181744_-\|TIGR00159-family-protein	unknown	unknown	gnl\|CDD\|224539
NC_022113.1\|WP_001292150.1\|2169082_2169517_+\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|227014
NC_022113.1\|WP_001141016.1\|2190270_2191713_-\|multidrug-efflux-MFS-transporter-LmrS	unknown	unknown	gnl\|CDD\|129794
NC_022113.1\|WP_000927367.1\|2166938_2169071_+\|BglG-family-transcription-antiterminator	unknown	unknown	gnl\|CDD\|226234
NC_022113.1\|WP_000884730.1\|2194719_2195907_-\|UDPGP-type-1-family-protein	unknown	unknown	gnl\|CDD\|133036
NC_022113.1\|WP_000370937.1\|2160940_2161798_-\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|223635
NC_022113.1\|WP_000495684.1\|2157806_2158898_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_022113.1\|WP_000908186.1\|2161865_2162648_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224044	COG1119, ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism].	1.75723e-107
NC_022113.1\|WP_000162591.1\|2181933_2182842_-\|arginase	gnl\|CDD\|212515	cd09989, Arginase, Arginase family. This family includes arginase, also known as arginase-like amidino hydrolase family, and related proteins. Arginase is a binuclear Mn-dependent metalloenzyme and catalyzes hydrolysis of L-arginine to L-ornithine and urea (Arg, EC 3.5.3.1), the reaction being the fifth and final step in the urea cycle, providing the path for the disposal of nitrogenous compounds. Arginase controls cellular levels of arginine and ornithine which are involved in protein biosynthesis, and in production of creatine, polyamines, proline and nitric acid. In vertebrates, at least two isozymes have been identified: type I (ARG1) cytoplasmic or hepatic liver-type arginase and type II (ARG2) mitochondrial or non-hepatic arginase. Point mutations in human arginase ARG1 gene lead to hyperargininemia with consequent mental disorders, retarded development and early death. Hyperargininemia is associated with a several-fold increase in the activity of the mitochondrial arginase (ARG2), causing persistent ureagenesis in patients. ARG2 overexpression plays a critical role in the pathophysiology of cholesterol mediated endothelial dysfunction. Thus, arginase is a therapeutic target to treat asthma, erectile dysfunction, atherosclerosis and cancer.	5.94976e-145
NC_022113.1\|WP_000884730.1\|2194719_2195907_-\|UDPGP-type-1-family-protein	gnl\|CDD\|133036	cd04193, UDPGlcNAc_PPase, UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc. UDP-N-acetylglucosamine (UDPGlcNAc) pyrophosphorylase (UAP) (also named GlcNAc1P uridyltransferase), catalyzes the reversible conversion of UTP and GlcNAc1 to PPi and UDPGlcNAc. UDP-N-acetylglucosamine (UDPGlcNAc), the activated form of GlcNAc, is a key precursor of N- and O-linked glycosylations. It is essential for the synthesis of chitin (a major component of the fungal cell wall) and of the glycosylphosphatidylinositol (GPI) linker which anchors a variety of cell surface proteins to the plasma membrane. In bacteria, UDPGlcNAc represents an essential precursor for both peptidoglycan and lipopolysaccharide biosynthesis. Human UAP has two isoforms, resulting from alternative splicing of a single gene and differing by the presence or absence of 17 amino acids. UDPGlcNAc pyrophosphorylase shares significant sequence and structure conservation with UDPglucose pyrophosphorylase.	9.19785e-146
NC_022113.1\|WP_000334466.1\|2162879_2164685_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	gnl\|CDD\|234729	PRK00331, PRK00331, isomerizing glutamine--fructose-6-phosphate transaminase.	0
NC_022113.1\|WP_001237527.1\|2192496_2193840_-\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.31901e-37
NC_022113.1\|WP_000894028.1\|2180000_2180933_-\|YbbR-like-domain-containing-protein	gnl\|CDD\|227193	COG4856, COG4856, Uncharacterized protein conserved in bacteria [Function unknown].	4.21538e-117
NC_022113.1\|WP_000958522.1\|2189058_2190123_-\|P-loop-NTPase	gnl\|CDD\|378455	pfam10609, ParA, NUBPL iron-transfer P-loop NTPase. This family contains ATPases involved in plasmid partitioning. It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits.	5.47694e-116
NC_022113.1\|WP_000047120.1\|2194017_2194701_-\|hemolysin-III-family-protein	gnl\|CDD\|224191	COG1272, COG1272, Predicted membrane protein, hemolysin III homolog [General function prediction only].	4.64044e-66
NC_022113.1\|WP_000347893.1\|2180934_2181744_-\|TIGR00159-family-protein	gnl\|CDD\|224539	COG1624, COG1624, Uncharacterized conserved protein [Function unknown].	4.57874e-103
NC_022113.1\|WP_000648736.1\|2169516_2170623_+\|mannitol-1-phosphate-5-dehydrogenase	gnl\|CDD\|235031	PRK02318, PRK02318, mannitol-1-phosphate 5-dehydrogenase; Provisional.	0
NC_022113.1\|WP_000521495.1\|2178618_2179974_-\|phosphoglucosamine-mutase	gnl\|CDD\|237670	PRK14316, glmM, phosphoglucosamine mutase; Provisional.	0
NC_022113.1\|WP_072435031.1\|2191901_2192375_-\|multidrug-efflux-transporter-SepA	gnl\|CDD\|374975	pfam17080, SepA, Multidrug Resistance efflux pump. SepA is a drug efflux protein that is involved in bacterial multidrug resistance. It is predicted to have four transmembrane domains.	1.1244e-29
NC_022113.1\|WP_000083795.1\|2165365_2166904_+\|PTS-mannitol-transporter-subunit-IICB	gnl\|CDD\|225123	COG2213, MtlA, Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism].	0
NC_022113.1\|WP_001292150.1\|2169082_2169517_+\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|227014	COG4668, MtlA, Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and metabolism].	6.01856e-62
NC_022113.1\|WP_001141016.1\|2190270_2191713_-\|multidrug-efflux-MFS-transporter-LmrS	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	6.86453e-81
NC_022113.1\|WP_000927367.1\|2166938_2169071_+\|BglG-family-transcription-antiterminator	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	9.39374e-67
NC_022113.1\|WP_000370937.1\|2160940_2161798_-\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|223635	COG0561, Cof, Predicted hydrolases of the HAD superfamily [General function prediction only].	1.15818e-59

>NC_022113.1|WP_000648736.1|2169516_2170623_+|mannitol-1-phosphate-5-dehydrogenase
MKAVHFGAGNIGRGFIGYILADNNVKVTFADVNEEIINALATGHQYDVILADESKTTTRVNNVAAINSMQPSEELKQAILEADIITTAVGVNILPIIAKSFAPFLKEKTNHVNIVACENAIMATDTLKKAVLDITGPLGNNIHFANSAVDRIVPLQKNENILDVMVEPFYEWVVEKDAWYGPELNHIKYVDDLTPYIERKLLTVNTGHAYLAYAGKFAGKATVLDAVKDSSIEAGLRRVLAETSQYITNEFDFTEAEQAGYVEKIIDRFNNSYLSDEVTRVGRGTLRKIGPKDRIIKPLAYLYNKDLERTGLLNTAALLLKYDDTADQETVEKNNYIKEHGLKAFLSEYAKVDDGLADEIIEAYNSLS
>NC_022113.1|WP_001292150.1|2169082_2169517_+|PTS-sugar-transporter-subunit-IIA
MSELFSNDNIFLNVNVNSQNEAIEKAGKALVDSGAVTDAYIQAMKDREQVVSTFMGNGLAIPHGTDEAKTNVIHSGLTLLQIPEGVDWDGEVVKVVVGIAGKDGEHLDLLSKIAITFSEEGNVDRIVQAKSAEEIKQVFEEADA
>NC_022113.1|WP_000927367.1|2166938_2169071_+|BglG-family-transcription-antiterminator
MLLSTREKEMIALLIKYHGQYITIHDIAQQLAVSSRTIHRELKGVEAYLTSFSLTLERANKKGLRITGADSDLNDLKQSIAQHQTIDLSVEEQKVIIIYALIQAKEPVKQYSLAQEIGVSVQTLAKMLDDLELDLNKYQLSLSRKRGEGIYLVGTESKKREFLSQLMVNNLNSTSVYSVIENHFVFHSLNQIHKDFVDLERIFNVERLLMDYLSALPYQLTESSYLTLTVHIVLSISRIKNGEYVALNDDIYDSVQNTFEHKVASELADKLGQIYDVTFNLAEIAFITIHLRGAKRKNLNDTSLNNRCEENKIKAFVKKVEMISGMTFADLDTLVDGLTLHLNPAINRLQANIETYNPLTDMIKFKYPRLFENVRLALNDCWPDLIFPESEIAFIVLHFGGSIKNQGNRFLNILVVCSSGMGTSRLLSTRLEQVFSEIERITQASVSDLKSLDLSQYDGIISTVNLDIDSPYLTVNPLLPDSDISYVAQFLNTKSTFQETRDKSSNMIDKDDVHIETKDIDGNTSFENEQTSYLTSVFEKHLSDEKSEQLMHHMRSGLTLLDSVKIVSTEVKQWQTYIADYLYQCDVINDPTSFAELLEQRLIDNPGWILSPYPVAIPHLRDNMIKHPMILITVLEEPLTLPSIQNDNQTIKYMISMFIPDNDFMASLISDLSEFLSLKLESIDTFMENPQELETLLRNKFLERIKKQFI
>NC_022113.1|WP_000083795.1|2165365_2166904_+|PTS-mannitol-transporter-subunit-IICB
MSQTEEKKGIGRRVQAFGSFLSSMIMPNIGAFIAWGFIAAIFIDNGWFPNKDLATLAGPMITYLIPLLIAFSGGRLIYDLRGGIIAATATMGVIVALPDTPMLLGAMIMGPLVGWLMKKTDQLIQPRTPQGFEMLFNNFSAGILGFIMTIAGFKILAPLMKFIMHILSVAVEALVHAHLLPLVSILVEPAKIVFLNNAINHGVFTPLGADQAAKAGQSILYTIESNPGPGLGILLAYMIFGKGTAKATSYGAGIIHFFGGIHEIYFPYVLMRPLLFIAVILGGMTGVATYQATGFGFKSPASPGSFIVYCLNAPRGEFLHMLLGVFLATLVSFVVAALIMKFTKEPKQDLEAATAQMETTKGKKSSVASKLVSSDKNVNTEENASGNVSETSSLDDDPEALLDNYNTEDVDAHNYNNINHVIFACDAGMGSSAMGASMLRNKFKKAGINDITVTNTAINQLPKDAQLVITQKKLTDRAIKQTPNAIHISVDNFLNSPRYEELLNNLKKDDQA
>NC_022113.1|WP_000334466.1|2162879_2164685_-|glutamine--fructose-6-phosphate-transaminase-(isomerizing)
MCGIVGYIGYDNAKELLLKGLEKLEYRGYDSAGIAVVNDDNTTVFKEKGRIAELRKVADSSDFDGPVGIGHTRWATHGVPNHENSHPHQSSNGRFTLVHNGVIENYEELKGEYLQGVSFISETDTEVIVQLVEYFSNQGLSTEEAFTKVVSLLHGSYALGLLDAEDKDTIYVAKNKSPLLLGVGEGFNVIASDALAMLQVTSEYKEIHDHEIVIVKKDEVIIKDADGNVVERDSYIAEIDASDAEKGVYAHYMLKEIHEQPAVMRRIIQEYQDAEGNLKIDQDIINDVKEADRIYVIAAGTSYHAGLVGKEFLEKWAGVPTEVHVASEFVYNMPLLSEKPLFVYISQSGETADSRAVLVETNKLGHKSLTITNVAGSTLSREADHTLLLHAGPEIAVASTKAYTAQIAVLSILSQIVAKEHGREADIDLLRELAKVTTAIEAIVDDAPIMEQIATDFLETTRNAFFIGRTIDYNVSLEGALKLKEISYIQAEGFAGGELKHGTIALIEEGTPVVGLATQEKVNLSIRGNVKEVVARGAHPCIISMEGLEKEGDTYVIPHVHELLTPLVSVVTLQLISYYAALHRDLDVDKPRNLAKSVTVE
>NC_022113.1|WP_000908186.1|2161865_2162648_-|ABC-transporter-ATP-binding-protein
MLIQLDQVGRMKQGKTILKNISWQINEGDKWILYGLNGAGKTTLLNILNAYEPATTGYVNLFGKMPGKVGYSTETVRQHIGFVSHSLLEKFQEGERVIDVVISGAFKSIGVYQDIDDEVRNEAHQLLKLVGMSAKAQQYIGYLSTGEKQRVMIARALMGQPQVLILDEPAAGLDFIARESLLSILDSLSDSYPTLAMIYVTHFIEEITGNFTKILLLKDGESVQQGLIDDILTSENMSRFFQKNVAVQRWNNRFSMAMLE
>NC_022113.1|WP_000370937.1|2160940_2161798_-|Cof-type-HAD-IIB-family-hydrolase
MDNVKAIFLDMDGTILHENNQASTYTKDVINRLREKGYKVFLATGRSHSEIHQLVPEDFAVNGIISSNGTIGEVDGEIIFKHGLSLAQVQQIINLAKRQQIYYEVFPFEGNRVSLKEDETWMRDMIRSQDPINGVSHSEWSSRQDALAGKIDWVTKFPEGEYSKIYLFSSNLEKITAFRDELKQNHVQLQISVSNSSRFNAETMAYQTDKGTGIKEMIEHFGINQKETLVIGDSDNDRAMFEFGHYTVAMKNARPEIQALTSDVTAYTNEEDGAAKYLAKHFLAD
>NC_022113.1|WP_001792784.1|2160123_2160282_+|hypothetical-protein
MSKSSDALFNSLTQSFELIEGVYNELVTDNLKIVMYKPRKESTSGRINRRFK
>NC_022113.1|WP_073392962.1|2159339_2159444_-|hypothetical-protein
MLLLERTSMSDFEMLMIVLTIIGLVLISTQDHKK
>NC_022113.1|WP_000495684.1|2157806_2158898_+|hypothetical-protein
MFTYFKSAFKNAKPQLLITLIYALIAFAVIAVVYLLANFQLAKYVQTIAIYSQFGQKPPVDAYLKVIAVLLIAAVVSLFVLVQIFIGITNVMKRAMSHEKVKFTDLFIAFKKGNYLKSVLIGLVSIAMIIVLSLLTSLLYKLFSPVSEMIMNSVQSSYADSTHLVGIAITTQSIIIIVVLLIKAIITWLLLIPIFNFMTSFVESTNDKVKTHLANGFKAMKNGQKTFFKFFIGILLLNLVIILFKTPVGYLISFNTQSLSQSVAENIIRVYTVITIILFVVIHAVILMGIVQYYLKRGQKITKDKVKTADKNKKVVTEPKNTKVENDKVTTSVETKTEKAQDSLNDNTTKTMTSDKPEDNQPK
>NC_022113.1|WP_000521495.1|2178618_2179974_-|phosphoglucosamine-mutase
MGKYFGTDGVRGVANQELTPELAFKLGRYGGYVLAHNKGEKHPRVLVGRDTRVSGEMLESALIAGLISIGAEVMRLGIISTPGVAYLTRDMGAELGVMISASHNPVADNGIKFFGSDGFKLSDEQENEIEALLDQENPELPRPVGNDIVHYSDYFEGAQKYLSYLKSTVDVNFEGLKIVLDGANGSTSSLAPFLFGDLEADTETIGCSPDGYNINEKCGSTHPEKLAEKVVETESDFGLAFDGDGDRIIAVDENGQIVDGDQIMFIIGQEMHKNQELNNDMIVSTVMSNLGFYKALEQEGIKSNKTKVGDRYVVEEMRRGNYNLGGEQSGHIVMMDYNTTGDGLLTGIQLASVIKMTGKSLSELAGQMKKYPQSLINVRVTDKYRVEENVDVKEVMTKVEVEMNGEGRILVRPSGTEPLVRVMVEAATDEDAERFAQQIADVVQDKMGLDK
>NC_022113.1|WP_000894028.1|2180000_2180933_-|YbbR-like-domain-containing-protein
MLESKWGLRFIAFLLALFFFLSVNNVFGNIFNTGNLGQKSSKTIQDVPVEILYNTKDLHLTKAPETVNVTISGPQSKIIKIENPEDLRVVIDLSNAKAGKYQEKYQVKGLADDIHYSVKPKLANITLENKVTKKMTVQPDVSQSDIDPLYKITKQEVSPQTVKITGGEEQLNDIAYLKATFKTNKKINGDTKDIAEVTAFDKKLNKLNVSIQPNEVNLQVKVEPFSKKVKVNVKQKGSLADDKELSSIDLEDKEIEIFGSRDDLQNISEVDAEVDLDGISESTEKTVKINLPEHVSKAEPSETKAYINVK
>NC_022113.1|WP_000347893.1|2180934_2181744_-|TIGR00159-family-protein
MDFSNFFQNLSTLKIVTSILDLLIVWYVLYLLITVFKGTKAIQLLKGILVIVIGQQISMILNLTATSKLFDIVIQWGVLALIVIFQPEIRRALEQLGRGSFLKRYTSNTYSKDEEKLIQSVSKALQYMAKRRIGALIVFEKETGLQDYIETGIAMDSNISQELLINVFIPNTPLHDGAMIIQGTKIAAAASYLPLSDSPKISKSLGTRHRAAVGISEVSDAFTVIVSEETGDISVTFDGKLRRDISNEIFEELLAEHWFGTRFQKKGVK
>NC_022113.1|WP_000162591.1|2181933_2182842_-|arginase
MTKKKGIDIIGVPSTFGQRKLGVDLGPTAIRYAGLIPRLKQLDLDVNDKGDIKVSAVDIEKFQSEQNGLRNYDEIIDVTQKLNKEVSASIENNRFPLVLGGDHSIAIGSVSAISKHYNNLGVIWYDAHGDLNIPEESPSGNIHGMPLRILTGEGPKELLELNSNVIKPENIVLIGMRDLDKGERQFIKDHNIKTFTMSDIDKLGIKEVIENTIEYLKSRNVDGVHLSLDVDALDPLETPGTGTRVLGGLTYRESHFALELLHQSQSVTSMDLVEVNPLIDHNNHTAEQSVSLVGTFFGETLL
>NC_022113.1|WP_000958522.1|2189058_2190123_-|P-loop-NTPase
MLTVDQVKELIGEIKDPIIDVPLKETEGIVEVSIKEEKEHVSVKVAMAQLGGAPQLDLQMAVVNVLKENGAKTVGIRFETLPEEKVNQFKPKEENKPKTIEGLLSQNNPVEFIAIASGKGGVGKSTVAVNLAVALAREGKKVGLVDADIYGFSVPDMMGIDEKPGINGKEVIPVERHGVKVISMAFFVEENAPVIWRGPMLGKMLTNFFTEVRWGDIEYLILDLPPGTGDVALDVHTMLPSSKEIIVTTPHPTAAFVAARAGAMAKHTDHSILGVIENMSYFESKETGNKEYVFGKGGGTKLADELNTQLLGELPLEQPSWNPKDFAPSIYQSDDRLGKIYSSIAQKVIAATNK
>NC_022113.1|WP_001141016.1|2190270_2191713_-|multidrug-efflux-MFS-transporter-LmrS
MAKVELTTRRRNFIVAVMLISAFVAILNQTLLNTALPSIMRELNINESTSQWLVTGFMLVNGVMIPLTAYLMDRIKTRPLYLAAMGTFLVGSIVAAMAPNFGVLMLARVIQAMGAGVLMPLMQFTLFTLFSKEHRGFAMGLAGLVIQFAPAIGPTVTGLIIDQASWRVPFIIIVGIALVAFIFGLISISSYNEVKYTKLDKRSVMYSTIGFGLMLYAFSSAGDLGFTSPVVIGAMIISSIIIYLFIRRQFNISNALLNLSVFKNRTFALCTISSMIIMMSMVGPALLIPLYVQNSLALSALLSGLVIMPGAIINGIMSVFTGKFYDKYGPRPLIYTGFTILTITTIMLCFLHTDTSYTYLIVVYAIRMFSVSLLMMPINTTGINSLKNEEISHGTAIMNFGRVMAGSLGTALMVTLMSFGAKIFSSTSPSHLTATEIKQQSIAIGVDISFAFVAVLVMAAYVIALFIREPKEIESNRRKF
>NC_022113.1|WP_072435031.1|2191901_2192375_-|multidrug-efflux-transporter-SepA
MVMNYLKHKFYNLLTTIIVLFIFVLSGAIFLTFLGFGLYGLSRILIYFRLGDFTYNRSMYDNLLYYGSYIIFGYFIVFAVEHLMDYFRKMLPENAYFRGATFHLISYMVATTLFYFIIHLNYVYINIDFWVIMVIIGFLYVCKLQFYPESKNLNNRK
>NC_022113.1|WP_001237527.1|2192496_2193840_-|MFS-transporter
MRLKSIVTVIALILIMFMAAIESSIISLALPTIKQDLNAGNLISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGSLMSGLSTHFSMLVISRVIQGFGSGVMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLFYINIPIAIIAIILVVWTFHFPEEETVAKSKFDTKGITLFYIFIGLIMFALLNQQHLYLNIIGFVLAILVALRLFNVEKKVSSPFLPVAEFNRMITLVFITDLLTAVCLMGFNLYIPVYLQEQLGLSPLQSGLVIFPLSVAWITLNFNLHHIEAKLSRKVIYLSSFTLLLLSSIIIAFGIKLPILIACVLILSGLSFGYIYTKDSVIVQEETSPIQMKKMMSFYGLTKNLGASIGSTIMGYLYALKSGLFGANLHNILGVVSLISVGLIVVWLIFYREAASQTKE
>NC_022113.1|WP_000047120.1|2194017_2194701_-|hemolysin-III-family-protein
MSKSSEKSNDTIVETFKDIIPLSFGEEIGNAASHGVAALLTLLVLPYAAVHSYIAYGTLASVSMSIYVISIFMMFISSTIYHSMQNETPHKYILRIIDHSMIYVAISGTYTPILLTVVGGWIGWTVFILLWGTTLWGILYKSIAVKVNQKLSLIVYLVMGWVGIILLPIIFIRTSWIFILFIFLGGVSYTIGAWFYAQKNRPYFHMIWHIFIVIASLLHLIAILYFM
>NC_022113.1|WP_000884730.1|2194719_2195907_-|UDPGP-type-1-family-protein
MLDKNQLAKYKQDHLCEYEKIMSNNEKEALEEKVASLDLDFIAKLYNDLYINKKTIDDVSAVSEVKYDIKSQMSDDEIKRLEEQGLQAIKEGQFAVLLMAGGQGTRLGYKGPKGSFEIEGVSLFELQAKQLKELHRQTGHKIQWYIMTSDINHEETLAYFESHNYFGYDQESIHFFKQDNIVALSEAGQLILNQQGRIMETPNGNGGVFKSLDKAGYLEEMSNNGVKYIFLNNIDNVLVKVLDPLFAGFTVEHDYDITSKTIQPKPGESVGRLVNVDCKDTVLEYSELDPEVANQFNNANIGIHAFKLGFILNAVNRELPYHLAIKNLKQLDENFGVIEQPTLKFELFYFDIFTYGTSFVTLQVPREEEFSPLKNKEGKDSVATATEDLRRMGLI

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Crispr_ID: NC_022113_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022113_12

2236461-2236586

Orphan

Consensus_repeat	Method
CCTCTTTACTCGAAAGCTCACAAAACTCTTGATATCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022113_12

>merge|NC_022113|12|2236461-2236586|CRISPRCasFinder
CCTCTTTACTCGAAAGCTCACAAAACTCTTGATATCACTGGTTTCTCATGATTTTTTAATGTTTTTATTTTGAGTTACTCGAAAATTTTCCTCTTTACTCGAAAGCTCACAAAACCCTTGATATCA

>NC_022113|12|10|2236461-2236586|CRISPRCasFinder
CCTCTTTACTCGAAAGCTCACAAAACTCTTGATATCA	CTGGTTTCTCATGATTTTTTAATGTTTTTATTTTGAGTTACTCGAAAATTTT
CCTCTTTACTCGAAAGCTCACAAAACCCTTGATATCA

Protein	Signature genes	Signature genes Name	Protein_function
NC_022113.1\|WP_001250038.1\|2238840_2239278_-\|50S-ribosomal-protein-L13	unknown	unknown	gnl\|CDD\|181703
NC_022113.1\|WP_000389651.1\|2241977_2242787_-\|energy-coupling-factor-transporter-ATPase	unknown	unknown	gnl\|CDD\|184207
NC_022113.1\|WP_000769709.1\|2231692_2232118_+\|MAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|367591
NC_022113.1\|WP_001044451.1\|2229517_2230372_-\|M23-family-metallopeptidase	unknown	unknown	gnl\|CDD\|366703
NC_022113.1\|WP_000101625.1\|2244723_2245113_-\|30S-ribosomal-protein-S11	unknown	unknown	gnl\|CDD\|180007
NC_022113.1\|WP_001221836.1\|2239525_2240320_-\|tRNA-pseudouridine(38-40)-synthase-TruA	unknown	unknown	gnl\|CDD\|234577
NC_022113.1\|WP_000179061.1\|2232508_2233213_-\|acetolactate-decarboxylase	unknown	unknown	gnl\|CDD\|226058
NC_022113.1\|WP_000569649.1\|2243704_2244649_-\|DNA-directed-RNA-polymerase-subunit-alpha	unknown	unknown	gnl\|CDD\|235359
NC_022113.1\|WP_001015495.1\|2225290_2226139_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381359
NC_022113.1\|WP_000136272.1\|2236215_2236395_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236623
NC_022113.1\|WP_000204276.1\|2236643_2238080_-\|putative-DNA-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|225420
NC_022113.1\|WP_000586768.1\|2241120_2241981_-\|energy-coupling-factor-transporter-ATPase	unknown	unknown	gnl\|CDD\|184205
NC_022113.1\|WP_000222271.1\|2227031_2229458_+\|polysaccharide-lyase-8-family-protein	unknown	unknown	gnl\|CDD\|238517
NC_022113.1\|WP_001791582.1\|2226867_2227035_+\|hypothetical-protein	unknown	unknown	unknown
NC_022113.1\|WP_000044369.1\|2230582_2231398_-\|HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|319792
NC_022113.1\|WP_000130145.1\|2233249_2234914_-\|acetolactate-synthase-AlsS	unknown	unknown	gnl\|CDD\|236312
NC_022113.1\|WP_000170975.1\|2238428_2238827_-\|30S-ribosomal-protein-S9	unknown	unknown	gnl\|CDD\|178888
NC_022113.1\|WP_000542274.1\|2243319_2243688_-\|50S-ribosomal-protein-L17	unknown	unknown	gnl\|CDD\|235522
NC_022113.1\|WP_001791584.1\|2235383_2235566_-\|hypothetical-protein	unknown	unknown	unknown
NC_022113.1\|WP_000791607.1\|2240324_2241131_-\|energy-coupling-factor-transporter-transmembrane-protein-EcfT	unknown	unknown	gnl\|CDD\|223692

Protein	Function_ID	Function_description	E-value
NC_022113.1\|WP_001250038.1\|2238840_2239278_-\|50S-ribosomal-protein-L13	gnl\|CDD\|181703	PRK09216, rplM, 50S ribosomal protein L13; Reviewed.	4.91074e-100
NC_022113.1\|WP_000389651.1\|2241977_2242787_-\|energy-coupling-factor-transporter-ATPase	gnl\|CDD\|184207	PRK13648, cbiO, cobalt transporter ATP-binding subunit; Provisional.	0
NC_022113.1\|WP_000769709.1\|2231692_2232118_+\|MAP-domain-containing-protein	gnl\|CDD\|367591	pfam03642, MAP, MAP domain. This presumed 110 amino acid residue domain is found in multiple copies in MAP (MHC class II analogue protein). The protein has been found in a wide range of extracellular matrix proteins.	8.17372e-34
NC_022113.1\|WP_001044451.1\|2229517_2230372_-\|M23-family-metallopeptidase	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	1.20929e-22
NC_022113.1\|WP_000101625.1\|2244723_2245113_-\|30S-ribosomal-protein-S11	gnl\|CDD\|180007	PRK05309, PRK05309, 30S ribosomal protein S11; Validated.	2.01588e-89
NC_022113.1\|WP_001221836.1\|2239525_2240320_-\|tRNA-pseudouridine(38-40)-synthase-TruA	gnl\|CDD\|234577	PRK00021, truA, tRNA pseudouridine(38-40) synthase TruA.	1.21958e-120
NC_022113.1\|WP_000179061.1\|2232508_2233213_-\|acetolactate-decarboxylase	gnl\|CDD\|226058	COG3527, AlsD, Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism].	1.39507e-119
NC_022113.1\|WP_000569649.1\|2243704_2244649_-\|DNA-directed-RNA-polymerase-subunit-alpha	gnl\|CDD\|235359	PRK05182, PRK05182, DNA-directed RNA polymerase subunit alpha; Provisional.	1.89947e-175
NC_022113.1\|WP_001015495.1\|2225290_2226139_-\|aldo/keto-reductase	gnl\|CDD\|381359	cd19133, AKR_AKR5F1, the AKR5F family of aldo-keto reductase (AKR). Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).	3.15275e-150
NC_022113.1\|WP_000136272.1\|2236215_2236395_-\|hypothetical-protein	gnl\|CDD\|236623	PRK09775, PRK09775, type II toxin-antitoxin system HipA family toxin YjjJ.	0.0004492
NC_022113.1\|WP_000204276.1\|2236643_2238080_-\|putative-DNA-binding-domain-containing-protein	gnl\|CDD\|225420	COG2865, COG2865, Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription].	1.62674e-63
NC_022113.1\|WP_000586768.1\|2241120_2241981_-\|energy-coupling-factor-transporter-ATPase	gnl\|CDD\|184205	PRK13646, cbiO, energy-coupling factor transporter ATPase.	0
NC_022113.1\|WP_000222271.1\|2227031_2229458_+\|polysaccharide-lyase-8-family-protein	gnl\|CDD\|238517	cd01083, GAG_Lyase, Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues, contributing to the invasive capacity of the pathogen. These are broad-specificity glycosaminoglycan lyases which recognize uronyl residues in polysaccharides and cleave their glycosidic bonds via a beta-elimination reaction to form a double bond between C-4 and C-5 of the non-reducing terminal uronyl residues of released products. Substrates include chondroitin, chondroitin 4-sulfate, chondroitin 6-sulfate, and hyaluronic acid. Family members include chondroitin AC lyase, chondroitin abc lyase, xanthan lyase, and hyalurate lyase.	0
NC_022113.1\|WP_000044369.1\|2230582_2231398_-\|HAD-IIB-family-hydrolase	gnl\|CDD\|319792	cd02605, HAD_SPP, sucrose-phosphatase, similar to Synechocystis sp PCC 6803 SPP. Sucrose-phosphatase (SPP; EC 3.1.3.24) catalyzes the dephosphorylation of sucrose-6(F)-phosphate (Suc6P)-the final step in the pathway of sucrose biosynthesis in plants and cyanobacteria. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	2.06188e-100
NC_022113.1\|WP_000130145.1\|2233249_2234914_-\|acetolactate-synthase-AlsS	gnl\|CDD\|236312	PRK08617, PRK08617, acetolactate synthase AlsS.	0
NC_022113.1\|WP_000170975.1\|2238428_2238827_-\|30S-ribosomal-protein-S9	gnl\|CDD\|178888	PRK00132, rpsI, 30S ribosomal protein S9; Reviewed.	2.2295e-82
NC_022113.1\|WP_000542274.1\|2243319_2243688_-\|50S-ribosomal-protein-L17	gnl\|CDD\|235522	PRK05591, rplQ, 50S ribosomal protein L17; Validated.	2.70058e-62
NC_022113.1\|WP_000791607.1\|2240324_2241131_-\|energy-coupling-factor-transporter-transmembrane-protein-EcfT	gnl\|CDD\|223692	COG0619, CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism].	2.81787e-49

>NC_022113.1|WP_000136272.1|2236215_2236395_-|hypothetical-protein
MTEIVEFLSDGKLASRLEIQETMGLQKSYTSELIAELKKLEIIGSEGRGPGTRYYLIRD
>NC_022113.1|WP_001791584.1|2235383_2235566_-|hypothetical-protein
MIDSVFWKKAFIPVYFIVAMLVFLLFRFYIKTNNFSIYLMIIFLMCLGTASIIYNYKNNR
>NC_022113.1|WP_000130145.1|2233249_2234914_-|acetolactate-synthase-AlsS
MTDKKYTAADMVIDTLKNNGVEYVFGIPGAKIDYLFNALIDDGPELIVTRHEQNAAMMAQGIGRLTGKPGVVLVTSGPGVSNLTTGLLTATSEGDPVLALGGQVKRNDLLRLTHQSIDNAALLKYSSKYSEEVQDPESLSEVMTNAIRIATSGKNGASFISIPQDVISSPVESKAISLCQKPNLGVPSEQDINDVIEAIKNASFPVLLAGMRSSSADETNAIRKLVERTNLPVVETFQGAGVISRELENHFFGRVGLFRNQVGDELLRKSDLVVTIGYDPIEYEASNWNKELETQIINIDEVQAEITNYMQPKKELIGNIAKTIEMISEKVDEPFINQQHLDELEQLRTHIDEETGIKATHEEGILHPVEIIESMQKVLTDDTTVTVDVGSHYIWMARNFRSYNPRHLLFSNGMQTLGVALPWAISAALVRPNTQVVSVAGDGGFLFSSQDLETAVRKNLNIIQLIWNDGKYNMVEFQEEMKYKRSSGVDFGPVDFVKYAESFGAKGLRVTNQEELEAAIKEGYETDGPVLIDIPVNYKDNIKLSTNMLPDVFN
>NC_022113.1|WP_000179061.1|2232508_2233213_-|acetolactate-decarboxylase
MASVLYQHGTLGTLMAGLLKGTASINELLQHGDLGIATLTGSNGEVIFLDGKAYHANEHKEFVELKGDELTPYATVTKFVADTSYETKDKSSEAVFAEIKEKMLSENLFSAVKISGLFKKMHVRMMPAQEPPYTRLIDSARRQPEQTETYVKGAVVGFFTPELFHGIGSAGFHVHFANDDRNFGGHVLDFEVEDVKVEIQNIETFEQHFPIQDEDFINANIDYKDIADEIREAE
>NC_022113.1|WP_000769709.1|2231692_2232118_+|MAP-domain-containing-protein
MKLKSFVTATLALGLLSTVGAALPSHEASADSNNGYKEMTMDGYHTVPYTISVDGITALHRTYFVFPENKKVLYQEIDSKVKNQLASQRGVTTEKINNAQTATYTLTLNDGNKKVVNLKKNDDAKNSIDPSTIKQIQIVVK
>NC_022113.1|WP_000044369.1|2230582_2231398_-|HAD-IIB-family-hydrolase
MSKRLLLFDFDETYFKHNTNEEDLSHLREMEKLLEKLTNNNEVITVVLTGSTFQSVMDKMDQVNMTFKPLHIFSDLSSKMFTWNNGEYVESETYKKKVLSEPFLFEDIEDILHHISAQYNVEFIPQRAFEGNETHYNFYFHSTGNHNNDRRILEVLVRYANDQNYTARFSRSNPLAGDPENAYDIDFTPSNAGKLYATQFLMKKYNIPVKSILGFGDSGNDEAYLSYLEHAYLMSNSRDEALKQKFRLTKYPYYQGITLHVKEFVEGKYDY
>NC_022113.1|WP_001044451.1|2229517_2230372_-|M23-family-metallopeptidase
MNKTNFGDYLNKSKSRKIYKIFDQNLKREFSYWQFRKLFKSYTWQSDVHELKVCTQNDGTIEQIWIDKANQFGVAVTWKDNSIIGFVMRPLINYDAIKNETTLKYAVPTTDCYEVFWGGDNELYNYHYLYPHQRYAIDLVIKENHKTYKNLGKVNADYFCFGKDIIAPANGTVEKVVNGVQDNSIGSTKESQFLGNYIVIKHAENEYSLIAHLQQYSIIVNEGQNVKYGDIIGKVGNSGNSTEPHIHFQVMNDKNIEACTSLKIRFINNRELIKGDVVCGLQGE
>NC_022113.1|WP_000222271.1|2227031_2229458_+|polysaccharide-lyase-8-family-protein
MTYRMKKWQKLSTITLLMAGVITLNGGEFRSIDKHQIAVADTNVQTTDYEKLRNIWLDVNYGYDKYDENNPDMKKKFEATENEAEKLLKEMKTESDRKYLWESSKDLDTKSADMTRTYRNIEKISEAMKHKNTKLKTDENKTKVKDALEWLHKNAYGKEPDKKVADLTSNFKNKTSRNTNLNWWDYEIGTPRALTNTLILLQEDFTDEEKKKYTAPIKTFAPDSDKILSSVGKSEPAKGGNLVDISKVKLLESIIEEDKDMMKKSIDSFNTVFTYAQNSATGKERNGFYKDGSYIDHQDVPYTGAYGVVLLEGISQMMPMIKETPFNDSNQNDTTLKSWIDDGFMPLIYKGEMMDLSRGRAISRENETSHSASATVMKSLLRLSDTMDKSTKAKYKKIVKTSVESDSSYKQTDYLSSYSDISKMKSLMEDSTISTNGLTQQLKIYNDMDRVTYHNKGLDFAFGLSMTSKNVARYESINGENLKGWHTGAGMSYLYNSDVKHYRDNFWATADMKRLAGTTTLDNEEPKSTDVKKSSKTFVGGTKFDDQHASIGMDFENQDKTLTAKKSYFILNDKIVFLGTGIKSTDSSKNPVTTIENRKANDYKLYKDDTQTTNSDNQETNSLFLESTNSTQNNIGYHFLNESKITVKKESHTGKWSDINKSQKDIQKTDEYYEVTQKHSNTDSKYAYVLYPGLSKDVFKSKASKVTVVKQEDDFHVVKDNESVWAGINYSDSAKTFEINNTKVEVKAKGMFILTKKDDNTYECSFYNPESTNSVSDIESKISMTGYSIINKNTSTSNESGVRFELTK
>NC_022113.1|WP_001791582.1|2226867_2227035_+|hypothetical-protein
MLKIWVIDCLYASTFFVDCLTVDSQLYTLTNFEKLNHYLIIIFIAHAQHKKETCQ
>NC_022113.1|WP_001015495.1|2225290_2226139_-|aldo/keto-reductase
MNHIEISKDVKIPVLGFGVFQIPQEQTAEAVKEAIKAGYRHIDTAQSYLNETEVGQGIEASGIDRSELFITTKVWIENVNYEDTIKSIERSLQRLNLDYIDLVLIHQPYNDVYGSWRALEELKETGKIKAIGVSNFGVDRIVDLGIHNQIQPQVNQIEINPFHQQEEQVAALQQENVVVEAWAPFAEGKNQLFQNQLLQAIADKYNKSIAQVILRWLVERDIVVLAKSVNPERMAQNLDIFDFELTEEDKQQIATLEESNSQFFSHADPEMIKALTSRELDV
>NC_022113.1|WP_000204276.1|2236643_2238080_-|putative-DNA-binding-domain-containing-protein
MTSSKYIEYLQTEVEGQLLDRKRASINPKDVAQHISAFANAEGGKLVIGIEDNGEISGFNHSKAKKKEVYIEAPFEHLYRIPKYTYEIIEVKKRDGTMDEILIFDIEPSYDAIITLKDDSVYLRINDKSRKLTHNQITNLEYDRGSRRFEEELVEYSSIEDVNEELVDEFKQLLNTNVDNEKLLKARGFMREGKLTVAGLLLFSNNINVYLPGARIRFMRYEGTKEESGTRLNIVKDITFDKALPVAIREARAFINTQLREYTFLGKEGRFVTLPEYPEFAWFEGMINSIVHRRYDNQGDHIRIKMFDDRLEISSPGALPASVTLENIKEERYSRNPKLAAALTQYKWVRESNEGVGRIFDEMKQYFLDDPVYSEPNNSSVQLALKNNIIARKKRETGRVSNIITPELFESLNEQQELIVRHLYNQGELTASKIANIIQRSVPTARKRLKELEEMNIISTHGSSKNDPKRTYYLLGFE
>NC_022113.1|WP_000170975.1|2238428_2238827_-|30S-ribosomal-protein-S9
MTLAQVEYRGTGRRKNSVARVRLVPGEGNITVNNRDVREYLPFESLILDLNQPFDVTETKGNYDVLVNVHGGGFTGQAQAIRHGIARALLEADPEYRGSLKRAGLLTRDPRMKERKKPGLKAARRSPQFSKR
>NC_022113.1|WP_001250038.1|2238840_2239278_-|50S-ribosomal-protein-L13
MRQTFMANESNIERKWYVIDAEGQTLGRLSSEVASILRGKNKVTYTPHVDTGDYVIVINASKIEFTGNKETDKVYYRHSNHPGGIKSITAGELRRTNPERLIENSIKGMLPSTRLGEKQGKKLFVYGGAEHPHAAQQPENYELRG
>NC_022113.1|WP_001221836.1|2239525_2240320_-|tRNA-pseudouridine(38-40)-synthase-TruA
MRILVEIAYQGNNFLGFQIQQNGRTVQQQFEKLLQRIHKRHVRIHPSSRTDRGVHAIQQYFHFDTDLNIPMSQWQYAMNRTLPDDIYVNNVVTVDDDFHCRYDCVGKRYRYKVYQAQQRDPFQSGLKTFIPEPLDLDKMNRAAQQFIGTHDFTGFCSQKTEVESKVRTLYQSEIVKTDDGFDYIVTGSGFLYNMVRVLVAFLIEVGKGRHEVSDVPKLLESKNRKNVPFTAPAEGLYLEKIYLDENELLKDFGNDIKIHRKKSL
>NC_022113.1|WP_000791607.1|2240324_2241131_-|energy-coupling-factor-transporter-transmembrane-protein-EcfT
MKNKLIIGRYLPINSFVHHLDPRAKLMFVFLFIILIFFCHSPLTYLWMFALILFFMRLAKIQLWFLIKGLTPIFFFLIFTLMMHIFLTKGGYVLVEWHGITIETNGILEGLYISLRLIGIVMIATIMTLSTSPIDLTDAFERLLAPLKMFKLPVHQLSMIMSIALRFIPTLMDELDKIILAQKSRGSEISSGNIATRIKSFIPLLVPLFISAFQRAEELAVAMEVRGYDANVKRTSYRQLKWQLRDTLSLIMIIPIAIILFVLKYSGV
>NC_022113.1|WP_000586768.1|2241120_2241981_-|energy-coupling-factor-transporter-ATPase
MIIRFDNVSYTYQKGTPYQHQAIHDVNTEFEQGKYYAIVGQTGSGKSTLIQNINALLKPTTGTVTVDDITITHKTKDKYIRPVRKRIGMVFQFPESQLFEDTVEREMIFGPKNFKMNLDEAKNYAHRLLMDLGFSRDVMSQSPFQMSGGQMRKIAIVSILAMNPDIIVVDEPTAGLDPQSKRQVMRLLKSLQTDENKTIILISHDMNEVARYADEVIVMKEGSIVSQTSPKELFKDKEKLADWHIGLPEIVQLQYDFEQKHQTKLKDIALTEEAFVSLYKEWQHEK
>NC_022113.1|WP_000389651.1|2241977_2242787_-|energy-coupling-factor-transporter-ATPase
MEDKNSVIVFKNVSFQYQSDASFTLKDVSFNIPKGQWTSIVGHNGSGKSTIAKLMIGIEKVKSGEIFYNNQAITDDNFEKLRKDIGIVFQNPDNQFVGSIVKYDVAFGLENHAVPHDEMHRRVSEALEQVDMLERADYEPNALSGGQKQRVAIASVLALNPSVIILDEATSMLDPDARQNLLDLVRKVKSEHNITIISITHDLSEAMEADHVIVMNKGTVYKEGTATEIFDHAEELTTIGLDLPFPIKINQMLGHQTSFLTYEGLVDQL
>NC_022113.1|WP_000542274.1|2243319_2243688_-|50S-ribosomal-protein-L17
MGYRKLGRTSDQRKAMLRDLATSLIISERIETTEARAKEVRSVVEKLITLGKKGDLASRRNAAKTLRNVEILNEDETTQTALQKLFGEIAERYTERQGGYTRILKQGPRRGDGAESVIIELV
>NC_022113.1|WP_000569649.1|2243704_2244649_-|DNA-directed-RNA-polymerase-subunit-alpha
MIEIEKPRIETIEISEDAKFGKFVVEPLERGYGTTLGNSLRRILLSSLPGAAVKYIEIEGVLHEFSAVDNVVEDVSTIIMNIKQLALKIYSEEDKTLEIDVRDEGEVTASDITHDSDVEILNPELKIATVSKGGHLKIRLVANKGRGYALAEQNNTSDLPIGVIPVDSLYSPVERVNYTVENTRVGQSSDFDKLTLDVWTNGSITPQESVSLAAKIMTEHLNIFVGLTDEAQNAEIMIEKEEDQKEKVLEMSIEELDLSVRSYNCLKRAGINSVQELADKSEADMMKVRNLGRKSLEEVKYKLEDLGLGLRKED
>NC_022113.1|WP_000101625.1|2244723_2245113_-|30S-ribosomal-protein-S11
MARKQVSRKRRVKKNIENGVAHIRSTFNNTIVTITDEFGNALSWSSAGALGFKGSKKSTPFAAQMASETASKSAMEHGLKTVEVTVKGPGPGRESAIRALQSAGLEVTAIRDVTPVPHNGCRPPKRRRV

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Crispr_ID: NC_022113_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022113_13

2750751-2750834

Orphan

Consensus_repeat	Method
TTTCGAAATTCTCTGTGTTGGGACCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022113_13

>merge|NC_022113|13|2750751-2750834|CRISPRCasFinder
TTTCGAAATTCTCTGTGTTGGGACCCACACCCTAACTCGCATTGCCTGTAGAATTTCTTTTCGAAATTCTCTGTGTTGGGGCCC

>NC_022113|13|11|2750751-2750834|CRISPRCasFinder
TTTCGAAATTCTCTGTGTTGGGACCC	ACACCCTAACTCGCATTGCCTGTAGAATTTCT
TTTCGAAATTCTCTGTGTTGGGGCCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_022113.1\|WP_001059079.1\|2748534_2748735_+\|cold-shock-protein	unknown	unknown	gnl\|CDD\|224197
NC_022113.1\|WP_000215590.1\|2751934_2752654_-\|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG	unknown	unknown	gnl\|CDD\|234637
NC_022113.1\|WP_001054111.1\|2748861_2749431_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NC_022113.1\|WP_000672024.1\|2744702_2744894_+\|peptide-resistance-ABC-transporter-activity-modulator-VraH	unknown	unknown	unknown
NC_022113.1\|WP_000779134.1\|2749683_2750079_-\|DUF3147-family-protein	unknown	unknown	gnl\|CDD\|288237
NC_022113.1\|WP_000742840.1\|2751052_2751892_-\|nucleoid-occlusion-protein	unknown	unknown	gnl\|CDD\|275105
NC_022113.1\|WP_000790915.1\|2746479_2747229_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|373922
NC_022113.1\|WP_000249664.1\|2752653_2754531_-\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-enzyme-MnmG	unknown	unknown	gnl\|CDD\|235362
NC_022113.1\|WP_000240855.1\|2756594_2756732_-\|50S-ribosomal-protein-L34	unknown	unknown	gnl\|CDD\|366117
NC_022113.1\|WP_000154162.1\|2741982_2742741_+\|peptide-resistance-ABC-transporter-ATP-binding-subunit-VraD	unknown	unknown	gnl\|CDD\|224059
NC_022113.1\|WP_000362509.1\|2754597_2755977_-\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE	unknown	unknown	gnl\|CDD\|235392
NC_022113.1\|WP_000143675.1\|2742730_2744611_+\|peptide-resistance-ABC-transporter-permease-subunit-VraE	unknown	unknown	gnl\|CDD\|376899
NC_022113.1\|WP_000586234.1\|2745980_2746478_-\|hypothetical-protein	unknown	unknown	unknown
NC_022113.1\|WP_000089284.1\|2747247_2748051_-\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173803
NC_022113.1\|WP_000491382.1\|2750146_2750500_-\|DUF3147-family-protein	unknown	unknown	gnl\|CDD\|288237
NC_022113.1\|WP_001789343.1\|2756120_2756474_-\|ribonuclease-P-protein-component	unknown	unknown	gnl\|CDD\|234782

Protein	Function_ID	Function_description	E-value
NC_022113.1\|WP_001059079.1\|2748534_2748735_+\|cold-shock-protein	gnl\|CDD\|224197	COG1278, CspC, Cold shock proteins [Transcription].	1.4289e-30
NC_022113.1\|WP_000215590.1\|2751934_2752654_-\|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG	gnl\|CDD\|234637	PRK00107, gidB, 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG.	3.53317e-96
NC_022113.1\|WP_001054111.1\|2748861_2749431_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	2.78153e-16
NC_022113.1\|WP_000779134.1\|2749683_2750079_-\|DUF3147-family-protein	gnl\|CDD\|288237	pfam11345, DUF3147, Protein of unknown function (DUF3147). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.	5.93989e-39
NC_022113.1\|WP_000742840.1\|2751052_2751892_-\|nucleoid-occlusion-protein	gnl\|CDD\|275105	TIGR04285, parB-like_partition_protein, nucleoid occlusion protein. This model describes nucleoid occlusion protein, a close homolog to ParB chromosome partitioning proteins including Spo0J in Bacillus subtilis. Its gene often is located near the gene for the Spo0J ortholog. This protein bind a specific DNA sequence and blocks cytokinesis from happening until chromosome segregation is complete.	1.78633e-112
NC_022113.1\|WP_000790915.1\|2746479_2747229_-\|hypothetical-protein	gnl\|CDD\|373922	pfam15526, Ntox21, Novel toxin 21. Bacterial genomes and plasmids encode a variety of peptide and protein toxins that mediate inter-bacterial competition. Bacteriocins are diffusible proteins that parasitize cell-envelope proteins to enter and kill bacteria. Contact-dependent growth inhibition (CDI) is one mechanism of inter-bacterial competition. Novel Toxin 21 (alternatively 16S rRNA endonuclease CdiA) belongs to a family of prokaryotic polymorphic toxin systems implicated in intra-specific conflicts. This RNase toxin found in bacterial polymorphic toxin systems, is proposed to adopt the BECR (Barnase-EndoU-ColicinE5/D-RelE) fold, with two conserved lysine residues and [DS]xDxxxH, RxG[ST] and RxxD motifs. In bacterial polymorphic toxin systems, the toxin is usually exported by the type 2, type 4, type 5 or type 7 secretion systems. This is also referred to as the E. cloacae CdiAC. The CdiAC proteins carry a variety of sequence-diverse C-terminal domains, which represent a collection of distinct toxins. Many CdiA-CT toxins have nuclease activities. In accord with the structural homology, CdiA-CT cleaves 16S rRNA at the same site as colicin E3 and this nuclease activity is responsible for growth inhibition.	3.28374e-23
NC_022113.1\|WP_000249664.1\|2752653_2754531_-\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-enzyme-MnmG	gnl\|CDD\|235362	PRK05192, PRK05192, tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG.	0
NC_022113.1\|WP_000240855.1\|2756594_2756732_-\|50S-ribosomal-protein-L34	gnl\|CDD\|366117	pfam00468, Ribosomal_L34, Ribosomal protein L34.	8.39798e-10
NC_022113.1\|WP_000154162.1\|2741982_2742741_+\|peptide-resistance-ABC-transporter-ATP-binding-subunit-VraD	gnl\|CDD\|224059	COG1136, SalX, ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms].	3.13228e-111
NC_022113.1\|WP_000362509.1\|2754597_2755977_-\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE	gnl\|CDD\|235392	PRK05291, trmE, tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE.	0
NC_022113.1\|WP_000143675.1\|2742730_2744611_+\|peptide-resistance-ABC-transporter-permease-subunit-VraE	gnl\|CDD\|376899	pfam02687, FtsX, FtsX-like permease family. This is a family of predicted permeases and hypothetical transmembrane proteins. Buchnera aphidicola LolC has been shown to transport lipids targeted to the outer membrane across the inner membrane. Both LolC and Streptococcus cristatus TptD have been shown to require ATP. This region contains three transmembrane helices.	3.91285e-06
NC_022113.1\|WP_000089284.1\|2747247_2748051_-\|S8-family-serine-peptidase	gnl\|CDD\|173803	cd07477, Peptidases_S8_Subtilisin_subset, Peptidase S8 family domain in Subtilisin proteins. This group is composed of many different subtilisins: Pro-TK-subtilisin, subtilisin Carlsberg, serine protease Pb92 subtilisin, and BPN subtilisins just to name a few. Pro-TK-subtilisin is a serine protease from the hyperthermophilic archaeon Thermococcus kodakaraensis and consists of a signal peptide, a propeptide, and a mature domain. TK-subtilisin is matured from pro-TK-subtilisin upon autoprocessing and degradation of the propeptide. Unlike other subtilisins though, the folding of the unprocessed form of pro-TK-subtilisin is induced by Ca2+ binding which is almost completed prior to autoprocessing. Ca2+ is required for activity unlike the bacterial subtilisins. The propeptide is not required for folding of the mature domain unlike the bacterial subtilases because of the stability produced from Ca2+ binding. Subtilisin Carlsberg is extremely similar in structure to subtilisin BPN'/Novo thought it has a 30% difference in amino acid sequence. The substrate binding regions are also similar and 2 possible Ca2+ binding sites have been identified recently. Subtilisin Carlsberg possesses the highest commercial importance as a proteolytic additive for detergents. Serine protease Pb92, the serine protease from the alkalophilic Bacillus strain PB92, also contains two calcium ions and the overall folding of the polypeptide chain closely resembles that of the subtilisins. Members of the peptidases S8 and S35 clan include endopeptidases, exopeptidases and also a tripeptidyl-peptidase. The S8 family has an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The S53 family contains a catalytic triad Glu/Asp/Ser. The stability of these enzymes may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	2.02571e-48
NC_022113.1\|WP_000491382.1\|2750146_2750500_-\|DUF3147-family-protein	gnl\|CDD\|288237	pfam11345, DUF3147, Protein of unknown function (DUF3147). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.	1.35852e-38
NC_022113.1\|WP_001789343.1\|2756120_2756474_-\|ribonuclease-P-protein-component	gnl\|CDD\|234782	PRK00499, rnpA, ribonuclease P; Reviewed.	3.11548e-51

>NC_022113.1|WP_000491382.1|2750146_2750500_-|DUF3147-family-protein
MFSIGSAILHFVIGGIAVALASIIADKVGGKLGGIIATMPAVFLAAIIALALDHRGTQLVEMSMNLSTGAIVGILSCILTVFLTSLYIKHKGYRKGAIFTVVCWFVISLAIFSIRHL
>NC_022113.1|WP_000779134.1|2749683_2750079_-|DUF3147-family-protein
MKLTLMKFFVGGFAVLLSYIVSVTLPWKEFGGIFATFPAVFLVSMFITGMQYGDKVAVHVSRGAVFGMTGVLVCILVTWMMLHMTHMWLISIIVGFLSWFISAVCIFEAVEFIAQKRLEKHSWKAGKSNSK
>NC_022113.1|WP_001054111.1|2748861_2749431_-|helix-turn-helix-transcriptional-regulator
MNLSKQIKKYRERDGYSQEYLAEKLYVSRQSISNWENDKSLPDIHNLLMMCDLFNVTLDDLVKGTIPFAPDIKAQRSLNLWTYVMLIFMTLAAILTGPLVVYWNWAWGITVIVIYGIGYYASMKIEDFKKVHKMDNYDRIVAFMNGKDPSEVQTTKARNIKTGVLSFIAFVGAIILIALISMHLANKFL
>NC_022113.1|WP_001059079.1|2748534_2748735_+|cold-shock-protein
MNNGTVKWFNAEKGFGFIEQENGGDVFVHFSGIASDGYKTLEEGQKVTFEITEGQRGDQAVNVQTV
>NC_022113.1|WP_000089284.1|2747247_2748051_-|S8-family-serine-peptidase
MSRNLIHLSIGVAIFIISFSFYLLNQPNNWAWSSLNICINDSKPSNVKVAILDTGINNTRINNNFVTKRYNAINNHNQITTDSNHATQVASIITYGEHKEKLIGISKSVSIYDVKVLDDNLKGDIDNIIKGITWSIKNDVNIIHMSFGFQRYNKELHDAIKNAKNKGIILVAAAGNNMDDYSDYPARFNEVYSITAIDKNNKPFIYAPTKKIDFKAPGVDVYTKGSKDELLTVNGTSFAAAYFTAYLTNNLEFRNDLPHILKEYPIK
>NC_022113.1|WP_000790915.1|2746479_2747229_-|hypothetical-protein
MKNKIIILFLAIIITFTYGNFAEASVVIKEANINNSNSKINTNKINENIYSKNNRNYIDNNFKSKDLNIESSLEHDLNTDKITVDASLKDNYNNKLDKTYDVKFLRIVNENDFKAEFTDQDTGEKIIYDTNEVKASIAPVVAVLVGFIAKQGLKKAIQKYGKTVVTSMIRTSPQVAAQAAKKLGYSATKHVSHGKKVFKKNSKGRPQYISVDKDGHRGGAWKGASSIKNLGSKKTRSGTYDANLKRIGD
>NC_022113.1|WP_000586234.1|2745980_2746478_-|hypothetical-protein
MIINLETQQIHFDLEHEIPYFQSPEKNRIRLDIDVLNKKQISNIINVIFNNQSKTKCTFLSEYLYPVKFREKTRIGRFFNITNWYEEIHSADEKYVIATIKNIKNKDLIDYSLYIKKGLVEPFIVFYNQENIFYISNAVIDIISVSKDTLGYIKSEFNDHCASPY
>NC_022113.1|WP_000672024.1|2744702_2744894_+|peptide-resistance-ABC-transporter-activity-modulator-VraH
MKFRELVKQSYEDLKNLTVTWYNVIALAIIVIVLSTVTTPIIGIPAGLLGGAYYLKRREEKGK
>NC_022113.1|WP_000143675.1|2742730_2744611_+|peptide-resistance-ABC-transporter-permease-subunit-VraE
MTFNHIVLKNLRQNLKHYAMYLFSLFFSIVLYFSFTTLQFTKGVNNDDSMAIIKKGALVGSIFLFIIIVIFLMYANHLFVKRRTREFALFQLIGLTRQNILKMLALEQMIVFIITGVVGVLCGIAGAQLLLSIVSKLMSLSINLSIHFEPMALVLTILMLIIAYILILFQSSLFLKRRSILSMMKDSVKTDVTTAKVTVIEVISGVLGIAMIALGYYMATEMFGTFKALTMAMTSPFIILFLTVVGAYLFFRSSVSLIFKTLKKSKNGRVSITDVVFTSSIMYRMKKNAMSLTIIAIISAVTVTVLCFAALSKSNTDQTLTSMAPNDFNVVASQDAQQFESKLSQQHITFSKNYYETITVDNVKDQVITLENGSDSGRTNSILSANTKLTGNNAIITNTKSLPNVINIHLNNDLVVKGTKNETFRVTQEDKDKVYPLNLSFNSPVIEVSPEKYQQLKTQNNVHTFYGYDIKQTSQKKKAQAIAKQFGDKIITYDDMKKEVDATNGILIFVTSFLGLAFLVAAGCIIYIKQMDETEDELSNFRILKRIGFTHTDMLKGLLLKITFNFGLPLLIAILHAVFAAIAFMKLMGNISFMPVIIVIIVYTLIYIVFALIAFVHSNKLIKKTI
>NC_022113.1|WP_000154162.1|2741982_2742741_+|peptide-resistance-ABC-transporter-ATP-binding-subunit-VraD
MTILSVQHVSKTYGKKHTFQALKDINFDIQKGEFVAIMGPSGSGKTTLLNVLSSIDQISSGSVIANGQELNKLNQKALAKFRKESLGFIFQDYSILPTLTVKENIMLPLSVQKMSKATMEENYKAITTALGIYDLGNKYPSELSGGQQQRTAAARAFVHKPQIIFADEPTGALDSKSANDLLQRLEEMNKSFDTTIVMVTHDPVAASFAERVIMLKDGQIHTQLYQEGRSKQAFYEDIVHLQSVLGGVSNDI
>NC_022113.1|WP_000742840.1|2751052_2751892_-|nucleoid-occlusion-protein
MKKPFSKLFGLKNKDDIIGHIEENRNSNVESIQIERIVPNRYQPRQVFEPNKIKELAESIHEHGLLQPIVVRPIEEDMFEIIAGERRFRAIQSLNLPQADVIIRDMDDEETAVVALIENIQRENLSVVEEAEAYKKLLEIGDTTQSELAKSLGKSQSFIANKLRLLKLAPKVLLRLREGKITERHARAVLSLSDSEQEALIEQVIAQKLNVKQTEDRVRQKTGPEKVKAQNLRFEQDVTQARDEVGKSIQAIQQTGLHVEHKDKDHEDYYEIKIRIYKR
>NC_022113.1|WP_000215590.1|2751934_2752654_-|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG
MTVEWLAEQLKEHNIELTETQKQQFQTYYRLLVEWNEKMNLTSITDEHDVYLKHFYDSIAPSFYFDFNQPISICDVGAGAGFPSIPLKIMFPQLKVTIVDSLNKRIQFLNYLASELQLQDVSFIHDRAETFGKGVYRESYDVVTARAVARLSVLSELCLPLVKKGGQFVALKSSKGEEELEEAKFAISVLGGNVTETHTFELPEDAGERQMFIIDKKRQTPKKYPRKPGTPNKTPLLEK
>NC_022113.1|WP_000249664.1|2752653_2754531_-|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-enzyme-MnmG
MVQEYDVIVIGAGHAGVEAGLASARRGAKTLMLTINLDNIAFMPCNPSVGGPAKGIVVREIDALGGQMAKTIDKTHIQMRMLNTGKGPAVRALRAQADKVLYQQEMKRVIEDEENLHIMQGMVDELIIEDNEVKGVRTNIGTEYLSKAVIITTGTFLRGEIILGNMKYSSGPNHQLPSITLSDNLRELGFDIVRFKTGTPPRVNSKTIDYSKTEIQPGDDVGRAFSFETTEYILDQLPCWLTYTNAETHKVIDDNLHLSAMYSGMIKGTGPRYCPSIEDKFVRFNDKPRHQLFLEPEGRNTNEVYVQGLSTSLPEHVQRQMLETIPGLEKADMMRAGYAIEYDAIVPTQLWPTLETKMIKNLYTAGQINGTSGYEEAAGQGLMAGINAAGKVLNTGEKILSRSDAYIGVLIDDLVTKGTNEPYRLLTSRAEYRLLLRHDNADLRLTDMGYELGMISEERYARFNEKRQQIDAEIKRLSDIRIKPNEHTQVIIEQHGGSRLKDGILAIDLLRRPEMTYDIILEILEEEHQLNADVEEQVEIQTKYEGYINKSLQQVEKVKRMEEKKIPEDLDYSKIDSLATEAREKLSEVKPLNIAQASRISGVNPADISILLIYLEQGKLQRVSD
>NC_022113.1|WP_000362509.1|2754597_2755977_-|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE
MDLDTITSISTPMGEGAIGIVRLSGPQAVEIADKLYKGKHLLNDVPSHTINYGHIIDPESKEVVEEVMVSVLRAPKTFTREDIIEINCHGGILTINRVLELTMTYGARMAEPGEFTKRAFLNGRIDLSQAEAVMDFIRSKTDRASKVAMNQIEGRLSDLIKKQRQSILEILAQVEVNIDYPEYDDVEDATTEFLLEQSKEIKQEINRLLDTGAQGKIMREGLSTVIVGKPNVGKSSMLNNLIQDNKAIVTEVAGTTRDVLEEYVNVRGVPLRLVDTAGIRETEDIVEKIGVERSRKALSQADLILFVLNNNEALTQEDYTLYEVVKNEDVIVIVNKMDLEQNIDINEVKDMIGDTPLIQTSMLKQEGIDELEIQIRDLFFGGEVQNQDMTYVSNSRHISLLKQARQTIQDAIDAAESGVPMDMVQIDLTRTWEILGEIIGETASDELIDQLFSQFCLGK
>NC_022113.1|WP_001789343.1|2756120_2756474_-|ribonuclease-P-protein-component
MLLEKAYRIKKNADFQRIYKKGHSVANRQFVVYTCNNKEIDHFRLGISVSKKLGNAVLRNKIKRAIRENFKVHKSHILAKDIIVIARQPAKDMTTLQIQNSLEHVLKIAKVFNKKIK
>NC_022113.1|WP_000240855.1|2756594_2756732_-|50S-ribosomal-protein-L34
MVKRTYQPNKRKHSKVHGFRKRMSTKNGRKVLARRRRKGRKVLSA

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_022113_3	3.1\|716508\|33\|NC_022113\|CRISPRCasFinder	716508-716540	33	NC_022113.1	966296-966328	1	0.97
NC_022113_13	13.1\|2750777\|32\|NC_022113\|CRISPRCasFinder	2750777-2750808	32	NC_022113.1	2309149-2309180	1	0.969
NC_022113_3	3.1\|716508\|33\|NC_022113\|CRISPRCasFinder	716508-716540	33	NC_022113.1	2309180-2309212	2	0.939
NC_022113_5	5.1\|840179\|26\|NC_022113\|CRISPRCasFinder	840179-840204	26	NC_022113.1	2051928-2051953	2	0.923
NC_022113_5	5.1\|840179\|26\|NC_022113\|CRISPRCasFinder	840179-840204	26	NC_022113.1	2114181-2114206	2	0.923
NC_022113_9	9.1\|1933801\|37\|NC_022113\|CRT	1933801-1933837	37	NC_022113.1	729775-729811	2	0.946
NC_022113_9	9.1\|1933801\|37\|NC_022113\|CRT	1933801-1933837	37	NC_022113.1	729833-729869	2	0.946
NC_022113_9	9.2\|1933859\|34\|NC_022113\|CRT	1933859-1933892	34	NC_022113.1	262981-263014	2	0.941
NC_022113_9	9.2\|1933859\|34\|NC_022113\|CRT	1933859-1933892	34	NC_022113.1	342788-342821	2	0.941
NC_022113_9	9.2\|1933859\|34\|NC_022113\|CRT	1933859-1933892	34	NC_022113.1	683341-683374	2	0.941
NC_022113_9	9.2\|1933859\|34\|NC_022113\|CRT	1933859-1933892	34	NC_022113.1	716547-716580	2	0.941
NC_022113_9	9.2\|1933859\|34\|NC_022113\|CRT	1933859-1933892	34	NC_022113.1	992453-992486	2	0.941
NC_022113_9	9.2\|1933859\|34\|NC_022113\|CRT	1933859-1933892	34	NC_022113.1	1717999-1718032	2	0.941
NC_022113_9	9.2\|1933859\|34\|NC_022113\|CRT	1933859-1933892	34	NC_022113.1	2274768-2274801	2	0.941
NC_022113_9	9.2\|1933859\|34\|NC_022113\|CRT	1933859-1933892	34	NC_022113.1	2415075-2415108	2	0.941
NC_022113_13	13.1\|2750777\|32\|NC_022113\|CRISPRCasFinder	2750777-2750808	32	NC_022113.1	716540-716571	2	0.938
NC_022113_13	13.1\|2750777\|32\|NC_022113\|CRISPRCasFinder	2750777-2750808	32	NC_022113.1	966386-966417	2	0.938

1. spacer 3.1|716508|33|NC_022113|CRISPRCasFinder matches to position: 966296-966328, mismatch: 1, identity: 0.97

attgggaatccaatttctctttgttggggccca	CRISPR spacer
attgggaatccaatttctctgtgttggggccca	Protospacer
******************** ************

2. spacer 13.1|2750777|32|NC_022113|CRISPRCasFinder matches to position: 2309149-2309180, mismatch: 1, identity: 0.969

acaccctaactcgcattgcctgtagaatttct	CRISPR spacer
acaccccaactcgcattgcctgtagaatttct	Protospacer
******.*************************

3. spacer 3.1|716508|33|NC_022113|CRISPRCasFinder matches to position: 2309180-2309212, mismatch: 2, identity: 0.939

attgggaatccaatttctctttgttggggccca	CRISPR spacer
attgggaatccaatttctctttgttgggactca	Protospacer
****************************.*.**

4. spacer 5.1|840179|26|NC_022113|CRISPRCasFinder matches to position: 2051928-2051953, mismatch: 2, identity: 0.923

cggggccccaacacagaagctggtgg	CRISPR spacer
cgcggccccaacacagaagctggcgg	Protospacer
** ********************.**

5. spacer 5.1|840179|26|NC_022113|CRISPRCasFinder matches to position: 2114181-2114206, mismatch: 2, identity: 0.923

cggggccccaacacagaagctggtgg	CRISPR spacer
cggggccccaacacaaaagctggcgg	Protospacer
***************.*******.**

6. spacer 9.1|1933801|37|NC_022113|CRT matches to position: 729775-729811, mismatch: 2, identity: 0.946

ccaacttgcacattattgtaagctgacagaaagtcag	CRISPR spacer
ccaacttgcacattattgtaagctggcggaaagtcag	Protospacer
*************************.*.*********

7. spacer 9.1|1933801|37|NC_022113|CRT matches to position: 729833-729869, mismatch: 2, identity: 0.946

ccaacttgcacattattgtaagctgacagaaagtcag	CRISPR spacer
ccaacttgcacattattgtaagctggcggaaagtcag	Protospacer
*************************.*.*********

8. spacer 9.2|1933859|34|NC_022113|CRT matches to position: 262981-263014, mismatch: 2, identity: 0.941

aacttgcattgtctgtagaatttcctttcgaaat	CRISPR spacer
aacttgcattgcctgtagaatttcttttcgaaat	Protospacer
***********.************.*********

9. spacer 9.2|1933859|34|NC_022113|CRT matches to position: 342788-342821, mismatch: 2, identity: 0.941

aacttgcattgtctgtagaatttcctttcgaaat	CRISPR spacer
aacttgcattgtttgtagaatttcttttcgaaat	Protospacer
************.***********.*********

10. spacer 9.2|1933859|34|NC_022113|CRT matches to position: 683341-683374, mismatch: 2, identity: 0.941

aacttgcattgtctgtagaatttcctttcgaaat	CRISPR spacer
aacttgcattgtttgtagaatttcttttcgaaat	Protospacer
************.***********.*********

11. spacer 9.2|1933859|34|NC_022113|CRT matches to position: 716547-716580, mismatch: 2, identity: 0.941

aacttgcattgtctgtagaatttcctttcgaaat	CRISPR spacer
aacttgcattgcctgtagaatttcttttcgaaat	Protospacer
***********.************.*********

12. spacer 9.2|1933859|34|NC_022113|CRT matches to position: 992453-992486, mismatch: 2, identity: 0.941

aacttgcattgtctgtagaatttcctttcgaaat	CRISPR spacer
aacttgcattgcctgtagaatttcttttcgaaat	Protospacer
***********.************.*********

13. spacer 9.2|1933859|34|NC_022113|CRT matches to position: 1717999-1718032, mismatch: 2, identity: 0.941

aacttgcattgtctgtagaatttcctttcgaaat	CRISPR spacer
aacttgcattgtctgtagaatttctttttgaaat	Protospacer
************************.***.*****

14. spacer 9.2|1933859|34|NC_022113|CRT matches to position: 2274768-2274801, mismatch: 2, identity: 0.941

aacttgcattgtctgtagaatttcctttcgaaat	CRISPR spacer
aacttgcattgtctgtagaatttctttttgaaat	Protospacer
************************.***.*****

15. spacer 9.2|1933859|34|NC_022113|CRT matches to position: 2415075-2415108, mismatch: 2, identity: 0.941

aacttgcattgtctgtagaatttcctttcgaaat	CRISPR spacer
aacttgcattgtctgtagaatttctttttgaaat	Protospacer
************************.***.*****

16. spacer 13.1|2750777|32|NC_022113|CRISPRCasFinder matches to position: 716540-716571, mismatch: 2, identity: 0.938

acaccctaactcgcattgcctgtagaatttct	CRISPR spacer
acaccccaacttgcattgcctgtagaatttct	Protospacer
******.****.********************

17. spacer 13.1|2750777|32|NC_022113|CRISPRCasFinder matches to position: 966386-966417, mismatch: 2, identity: 0.938

acaccctaactcgcattgcctgtagaatttct	CRISPR spacer
acaccccaacttgcattgcctgtagaatttct	Protospacer
******.****.********************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_022113_1	1.1\|564051\|29\|NC_022113\|CRISPRCasFinder	564051-564079	29	NZ_CP026273	Klebsiella oxytoca strain KONIH4 plasmid pKOX-ea2b, complete sequence	142439-142467	8	0.724

1. spacer 1.1|564051|29|NC_022113|CRISPRCasFinder matches to NZ_CP026273 (Klebsiella oxytoca strain KONIH4 plasmid pKOX-ea2b, complete sequence) position: , mismatch: 8, identity: 0.724

ccgcacaactgcataaatccctctaatcg	CRISPR spacer
attcacaactatataaatccctctaaatt	Protospacer
 . *******..************** .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

661723 : 669542

Hokovirus(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000244416.1\|661723_662779_-	two-component system sensor histidine kinase SaeS	A0A1V0SGX0	Hokovirus	3.6e-14	29.8
WP_000149344.1\|662778_663465_-	response regulator transcription factor	NA	NA	NA	NA
WP_001037807.1\|663439_663913_-	DoxX family protein	NA	NA	NA	NA
WP_001093552.1\|664254_664695_-	DM13 domain-containing protein	NA	NA	NA	NA
WP_000637686.1\|664974_665559_-	hypothetical protein	NA	NA	NA	NA
WP_001062968.1\|665657_666371_-	7-carboxy-7-deazaguanine synthase QueE	A0A1U9WRB6	Streptococcus_virus	6.5e-52	43.5
WP_000941336.1\|666374_666794_-	6-carboxytetrahydropterin synthase QueD	S4U060	uncultured_phage	6.3e-07	28.7
WP_000446724.1\|666795_667464_-	7-cyano-7-deazaguanine synthase QueC	A0A2H4J8Q7	uncultured_Caudovirales_phage	9.6e-66	57.5
WP_000604510.1\|667813_668407_+	aminodeoxychorismate/anthranilate synthase component II	A0A0P0IKJ1	Acinetobacter_phage	2.6e-38	43.5
WP_001217804.1\|668390_669542_+	anthranilate synthase component I family protein	S4VNU7	Pandoravirus	2.1e-23	36.1

DBSCAN-SWA_2

681514 : 695652

uncultured_Caudovirales_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000663016.1\|681514_682573_+	histidinol-phosphate transaminase	A0A0H3TLT9	Faustovirus	5.7e-20	26.5
WP_000197262.1\|682731_683274_+	5'-3'-deoxyribonucleotidase	NA	NA	NA	NA
WP_000429002.1\|683825_684743_-	diacylglycerol kinase family lipid kinase	A0A1V0SBJ0	Catovirus	8.2e-07	22.0
WP_031788440.1\|684833_684935_+	hypothetical protein	NA	NA	NA	NA
WP_000193750.1\|685012_686518_-	peptide MFS transporter	A0A0P0IY73	Acinetobacter_phage	2.0e-58	32.2
WP_000930016.1\|686857_687358_-	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	E7DN65	Pneumococcus_phage	2.7e-52	66.2
WP_001068491.1\|687377_688244_-	DMT family transporter	NA	NA	NA	NA
WP_000692521.1\|689045_689444_+	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A2H4J545	uncultured_Caudovirales_phage	1.2e-52	72.0
WP_000855505.1\|689406_691512_+	class 1b ribonucleoside-diphosphate reductase subunit alpha	A0A2H4J2N6	uncultured_Caudovirales_phage	0.0e+00	91.7
WP_000562498.1\|691631_692603_+	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A2H4J4P3	uncultured_Caudovirales_phage	4.2e-171	91.3
WP_000876309.1\|692979_693951_+	ABC transporter permease	A0A2H4IY97	uncultured_Caudovirales_phage	1.0e-140	79.9
WP_001245566.1\|693937_694894_+	iron chelate uptake ABC transporter family permease subunit	A0A2H4J116	uncultured_Caudovirales_phage	5.5e-06	60.0
WP_000616865.1\|694890_695652_+	ABC transporter ATP-binding protein	Q9EMR9	Amsacta_moorei_entomopoxvirus	7.2e-17	30.1

DBSCAN-SWA_3

778769 : 794413

Staphylococcus_phage(89.47%)

integrase,terminase,coat

attL 778610:778629|attR 794868:794887

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
778610:778629	attL	NA	NA	NA	NA
WP_000270271.1\|778769_779990_-\|integrase	site-specific integrase	Q4ZE80	Staphylococcus_phage	1.1e-99	47.3
WP_025173845.1\|780003_781392_-	SAP domain-containing protein	NA	NA	NA	NA
WP_001661454.1\|781418_781991_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_000560872.1\|782162_782384_+	helix-turn-helix transcriptional regulator	A0A2H4JFN1	uncultured_Caudovirales_phage	2.0e-07	43.5
WP_000124597.1\|782384_782657_+	helix-turn-helix domain-containing protein	Q4ZE77	Staphylococcus_phage	7.7e-38	84.4
WP_000784891.1\|782668_782824_+	hypothetical protein	NA	NA	NA	NA
WP_001231375.1\|782808_783012_+	hypothetical protein	A0A1W6JQF4	Staphylococcus_phage	1.0e-31	100.0
WP_000695073.1\|783013_783397_+	hypothetical protein	A0A1W6JQI7	Staphylococcus_phage	5.2e-56	89.8
WP_001103971.1\|783397_783691_+	DUF1474 family protein	A0A1W6JQH0	Staphylococcus_phage	1.3e-43	100.0
WP_001002696.1\|783778_784648_+	primase alpha helix C-terminal domain-containing protein	Q4ZE74	Staphylococcus_phage	1.1e-162	95.2
WP_000447476.1\|784661_786371_+	DUF927 domain-containing protein	Q4ZE73	Staphylococcus_phage	0.0e+00	95.8
WP_000356930.1\|786700_787081_+	hypothetical protein	Q4ZE71	Staphylococcus_phage	1.5e-68	98.4
WP_001047696.1\|787077_787719_+	hypothetical protein	Q4ZE67	Staphylococcus_phage	1.9e-111	93.4
WP_001190615.1\|788254_788596_+	hypothetical protein	Q4ZE66	Staphylococcus_phage	1.4e-57	99.1
WP_000846285.1\|788607_789186_+	hypothetical protein	A0A2H4JBG0	uncultured_Caudovirales_phage	1.4e-28	38.4
WP_000448773.1\|789203_789422_+	hypothetical protein	NA	NA	NA	NA
WP_000771367.1\|789472_790000_+\|coat	spore coat protein	Q4ZE87	Staphylococcus_phage	1.6e-87	96.0
WP_025173847.1\|790131_790344_+	hypothetical protein	Q4ZE86	Staphylococcus_phage	1.7e-29	91.4
WP_001293081.1\|790340_790910_+\|terminase	terminase small subunit	A0A1W6JQF0	Staphylococcus_phage	6.0e-101	97.4
WP_001794228.1\|791110_792133_+	hypothetical protein	NA	NA	NA	NA
WP_000091245.1\|792151_792715_+	hypothetical protein	NA	NA	NA	NA
WP_001035614.1\|792963_793518_-	DUF4888 domain-containing protein	A0A1W6JQE5	Staphylococcus_phage	4.7e-74	76.6
WP_001788502.1\|793892_794045_+	hypothetical protein	A0A0F6N3H2	Staphylococcus_phage	3.1e-20	100.0
WP_000139425.1\|794115_794226_+	hypothetical protein	W5R8J7	Staphylococcus_phage	3.8e-12	97.2
WP_001286805.1\|794227_794413_+	hypothetical protein	A0A0F6N3H3	Staphylococcus_phage	2.7e-26	100.0
794868:794887	attR	NA	NA	NA	NA

DBSCAN-SWA_4

881762 : 930898

Bacillus_virus(22.22%)

transposase,tRNA,protease,holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000121211.1\|881762_882710_-\|transposase	IS30-like element ISSau1 family transposase	Q9MBM9	Staphylococcus_prophage	1.1e-184	100.0
WP_001067041.1\|884344_885331_+	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	1.8e-15	30.0
WP_000427776.1\|885333_886314_+	dipeptide ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	2.7e-16	34.1
WP_000593417.1\|886306_887269_+	ABC transporter permease	NA	NA	NA	NA
WP_001180271.1\|887280_888162_+	ABC transporter permease	NA	NA	NA	NA
WP_094409958.1\|888250_889818_-\|transposase	IS3-like element ISSau2 family transposase	A0A0C5AEA5	Paenibacillus_phage	1.0e-49	51.8
WP_020967619.1\|890113_891760_+\|transposase	IS1182 family transposase	A0ZS58	Staphylococcus_virus	4.1e-291	98.7
WP_000448933.1\|891786_892776_-\|tRNA	tryptophan--tRNA ligase	NA	NA	NA	NA
WP_000258003.1\|893070_893466_+	transcriptional regulator Spx	NA	NA	NA	NA
WP_001217728.1\|893836_894556_+	adaptor protein MecA	NA	NA	NA	NA
WP_000959276.1\|894676_895663_+	competence protein CoiA	NA	NA	NA	NA
WP_000082722.1\|895710_897519_+	oligoendopeptidase F	A0A1X9I5X5	Streptococcus_phage	9.3e-47	24.5
WP_000896691.1\|897978_898785_-\|protease	protease adaptor protein YjbH	NA	NA	NA	NA
WP_000214067.1\|898807_899173_-	truncated hemoglobin	NA	NA	NA	NA
WP_000224620.1\|899276_899870_-	CYTH domain-containing protein	NA	NA	NA	NA
WP_001242102.1\|900055_900403_+	hypothetical protein	NA	NA	NA	NA
WP_001077683.1\|900419_901055_+	GTP pyrophosphokinase family protein	NA	NA	NA	NA
WP_001270834.1\|901071_901881_+	NAD kinase	NA	NA	NA	NA
WP_000669938.1\|901877_902732_+	RluA family pseudouridine synthase	NA	NA	NA	NA
WP_000062404.1\|902752_904138_+	magnesium transporter	NA	NA	NA	NA
WP_000395156.1\|904147_905992_+	monovalent cation:proton antiporter family protein	NA	NA	NA	NA
WP_000933195.1\|906269_907040_+	enoyl-ACP reductase FabI	NA	NA	NA	NA
WP_000933110.1\|907234_908320_-	AI-2E family transporter	NA	NA	NA	NA
WP_000570704.1\|908661_910230_+	alanine:cation symporter family protein	NA	NA	NA	NA
WP_000889176.1\|910372_911131_+	esterase family protein	NA	NA	NA	NA
WP_001060544.1\|911296_912022_+	hypothetical protein	NA	NA	NA	NA
WP_000355329.1\|912023_912875_+	hypothetical protein	NA	NA	NA	NA
WP_000600387.1\|913617_914127_+	2'-5' RNA ligase family protein	NA	NA	NA	NA
WP_001154224.1\|914239_915430_-	MFS transporter	NA	NA	NA	NA
WP_000258649.1\|915407_916583_-	diglucosyl diacylglycerol synthase	NA	NA	NA	NA
WP_000340133.1\|917014_918499_+	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L- lysine ligase	NA	NA	NA	NA
WP_001794242.1\|918479_918740_+	YueH family protein	NA	NA	NA	NA
WP_001049957.1\|918739_920302_+	peptide chain release factor 3	A0A1S5SF82	Streptococcus_phage	2.2e-36	28.2
WP_000928413.1\|920603_921407_+	TerC family protein	S5MAL1	Bacillus_phage	1.6e-30	40.5
WP_001794169.1\|921625_923950_+	trypsin-like peptidase domain-containing protein	W5SAB9	Pithovirus	4.0e-10	26.8
WP_000021872.1\|923966_925325_+	TrkH family potassium uptake protein	NA	NA	NA	NA
WP_000414169.1\|925463_926975_+	bifunctional metallophosphatase/5'-nucleotidase	NA	NA	NA	NA
WP_000287265.1\|927463_928033_-	competence protein ComK	NA	NA	NA	NA
WP_000876825.1\|928242_928461_+	IDEAL domain-containing protein	NA	NA	NA	NA
WP_000668820.1\|928541_929528_-	lipoate--protein ligase	NA	NA	NA	NA
WP_000214898.1\|929726_929903_+	YkvS family protein	NA	NA	NA	NA
WP_001033867.1\|929917_930520_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_099119695.1\|930820_930898_+\|holin	putative holin-like toxin	NA	NA	NA	NA

DBSCAN-SWA_5

967766 : 976239

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000861570.1\|967766_968249_+	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	8.0e-22	44.7
WP_001010391.1\|968235_969360_+	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
WP_000174050.1\|969363_970068_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	M4R1E8	Synechococcus_phage	7.3e-48	41.6
WP_000848351.1\|970067_970331_+	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_000666808.1\|970332_971004_+	phosphoribosylformylglycinamidine synthase I	NA	NA	NA	NA
WP_000032734.1\|970996_973186_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	5.1e-140	39.2
WP_000483708.1\|973164_974649_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	8.5e-46	31.7
WP_000030814.1\|974641_975670_+	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	7.6e-62	41.4
WP_000238673.1\|975672_976239_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	3.6e-29	40.1

DBSCAN-SWA_6

1425384 : 1509936

100

Staphylococcus_phage(66.67%)

tRNA,tail,protease,portal,capsid,integrase,terminase,holin,head

attL 1460149:1460177|attR 1504306:1504334

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000858795.1\|1425384_1426677_-\|tRNA	asparagine--tRNA ligase	A0A2P1EMB4	Moumouvirus	4.3e-54	30.0
WP_000525060.1\|1426998_1429692_-	ATP-dependent helicase DinG	A0A1X9I5C8	Streptococcus_phage	8.2e-47	34.4
WP_000049917.1\|1429715_1430687_-	biotin--[acetyl-CoA-carboxylase] ligase	NA	NA	NA	NA
WP_000361536.1\|1430673_1431876_-\|tRNA	CCA tRNA nucleotidyltransferase	H7BUW3	unidentified_phage	1.4e-35	42.5
WP_000690024.1\|1431880_1433023_-	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA	NA	NA	NA	NA
WP_000839927.1\|1433266_1433584_-	nucleotide pyrophosphohydrolase	NA	NA	NA	NA
WP_001827022.1\|1433919_1434600_-	zinc metallopeptidase	NA	NA	NA	NA
WP_000154479.1\|1434671_1435259_-	DUF1405 domain-containing protein	NA	NA	NA	NA
WP_000005208.1\|1435248_1435824_-	YpiB family protein	G3MAV7	Bacillus_virus	4.6e-08	27.2
WP_000389521.1\|1435837_1437082_-	hypothetical protein	NA	NA	NA	NA
WP_000245891.1\|1437088_1438387_-	3-phosphoshikimate 1-carboxyvinyltransferase	NA	NA	NA	NA
WP_000776318.1\|1438396_1439461_-	3-dehydroquinate synthase	NA	NA	NA	NA
WP_001269937.1\|1439486_1440653_-	chorismate synthase	A0A291AU41	Pandoravirus	1.5e-34	32.3
WP_000442480.1\|1441121_1441571_-	nucleoside-diphosphate kinase	D2E8E1	Anguillid_herpesvirus	2.4e-28	43.8
WP_001096481.1\|1441662_1442622_-	polyprenyl synthetase family protein	A0A1V0SE37	Indivirus	1.3e-10	24.4
WP_000774688.1\|1442623_1443349_-	demethylmenaquinone methyltransferase	NA	NA	NA	NA
WP_000450555.1\|1443351_1443924_-	heptaprenyl diphosphate synthase component 1	NA	NA	NA	NA
WP_001043863.1\|1444354_1444627_-	HU family DNA-binding protein	A7KV42	Bacillus_phage	4.2e-28	73.3
WP_000161753.1\|1444797_1445796_-	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase	NA	NA	NA	NA
WP_000165530.1\|1445812_1447123_-	ribosome biogenesis GTPase Der	NA	NA	NA	NA
WP_000133953.1\|1447344_1448520_-	30S ribosomal protein S1	NA	NA	NA	NA
WP_001791199.1\|1448776_1448968_-	hypothetical protein	NA	NA	NA	NA
WP_001791200.1\|1449084_1449201_-	hypothetical protein	NA	NA	NA	NA
WP_000644393.1\|1449231_1449891_-	(d)CMP kinase	NA	NA	NA	NA
WP_000681744.1\|1449967_1450936_+	asparaginase	NA	NA	NA	NA
WP_001174260.1\|1451050_1452037_-	YpdA family putative bacillithiol disulfide reductase	NA	NA	NA	NA
WP_016186859.1\|1452197_1452284_-	hypothetical protein	NA	NA	NA	NA
WP_000069298.1\|1452421_1453882_-	elastin-binding protein EbpS	NA	NA	NA	NA
WP_000902107.1\|1454034_1455414_-	ATP-dependent DNA helicase RecQ	L7RCS0	Acanthamoeba_polyphaga_moumouvirus	2.9e-56	33.3
WP_001163814.1\|1455403_1456357_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_001151997.1\|1456464_1456713_+	ferredoxin	A0A127AYY7	Bacillus_phage	8.3e-15	48.0
WP_001186908.1\|1456818_1457364_-	ECF transporter S component	NA	NA	NA	NA
WP_001799520.1\|1457642_1457807_-	hypothetical protein	NA	NA	NA	NA
WP_000913238.1\|1458977_1459883_-	DUF1672 domain-containing protein	NA	NA	NA	NA
WP_000470336.1\|1459972_1460158_-	hypothetical protein	A0ZS61	Staphylococcus_virus	1.7e-25	100.0
1460149:1460177	attL	NA	NA	NA	NA
WP_025173859.1\|1460398_1461391_-	Panton-Valentine bi-component leukocidin subunit F	A0A2I6PEU3	Staphylococcus_phage	1.9e-182	100.0
WP_000239544.1\|1461386_1462325_-	Panton-Valentine bi-component leukocidin subunit S	A0A2I6PF61	Staphylococcus_phage	1.7e-180	100.0
WP_000909207.1\|1464637_1466092_-	N-acetylmuramoyl-L-alanine amidase	M1TB12	Staphylococcus_phage	3.4e-289	100.0
WP_000339141.1\|1466102_1466405_-\|holin	phage holin	A0A2I6PF56	Staphylococcus_phage	3.1e-48	100.0
WP_000340978.1\|1466530_1466905_-	hypothetical protein	G4KNR3	Staphylococcus_phage	7.8e-33	81.5
WP_001262620.1\|1466960_1467248_-	hypothetical protein	C5I682	Staphylococcus_phage	9.9e-44	100.0
WP_001000058.1\|1467293_1467446_-	hypothetical protein	A0A1W6JPL6	Staphylococcus_phage	7.6e-19	100.0
WP_020967630.1\|1467438_1471221_-	structural protein	A0A1X9H096	Staphylococcus_phage	0.0e+00	98.2
WP_001154327.1\|1471236_1472727_-\|tail	phage tail family protein	D2JLF8	Staphylococcus_phage	8.2e-299	100.0
WP_000570353.1\|1477435_1477558_-	hypothetical protein	D2JLF6	Staphylococcus_phage	6.9e-15	100.0
WP_000442601.1\|1477617_1478064_-	hypothetical protein	D2JLF5	Staphylococcus_phage	5.4e-73	100.0
WP_000570652.1\|1478128_1479082_-	Ig-like domain-containing protein	A7TWD0	Staphylococcus_phage	6.2e-175	100.0
WP_000611452.1\|1479082_1479463_-	hypothetical protein	D2JLF3	Staphylococcus_phage	5.8e-68	100.0
WP_000501244.1\|1479459_1479837_-	HK97 gp10 family phage protein	D2JLF2	Staphylococcus_phage	1.1e-61	100.0
WP_000975314.1\|1479836_1480172_-\|head,tail	head-tail adaptor protein	A7TWC7	Staphylococcus_phage	1.1e-59	100.0
WP_001177484.1\|1480158_1480491_-\|head,tail	phage head-tail connector protein	A7TWQ4	Staphylococcus_phage	2.1e-58	100.0
WP_001252099.1\|1480499_1480658_-	hypothetical protein	D2JLE9	Staphylococcus_phage	3.2e-20	100.0
WP_000849950.1\|1480693_1481941_-\|capsid	phage major capsid protein	A7TWC4	Staphylococcus_phage	5.0e-209	100.0
WP_000032525.1\|1482028_1482613_-\|head,protease	HK97 family phage prohead protease	D2JLE7	Staphylococcus_phage	9.8e-107	100.0
WP_000511063.1\|1482605_1483856_-\|portal	phage portal protein	A0ZS41	Staphylococcus_virus	9.7e-237	99.8
WP_000365300.1\|1483861_1484062_-	hypothetical protein	D2JLE5	Staphylococcus_phage	1.0e-26	100.0
WP_000133304.1\|1484075_1485770_-\|terminase	phage terminase large subunit	D2JLE4	Staphylococcus_phage	0.0e+00	100.0
WP_000919026.1\|1485772_1486240_-\|terminase	phage terminase small subunit P27 family	D2JLE3	Staphylococcus_phage	1.1e-81	100.0
WP_000817289.1\|1486369_1486714_-	HNH endonuclease	D2JLE2	Staphylococcus_phage	4.2e-65	100.0
WP_000406191.1\|1486728_1487181_-	nucleoside triphosphate pyrophosphohydrolase family protein	D2JLE1	Staphylococcus_phage	1.4e-79	100.0
WP_000282748.1\|1487295_1487766_-	hypothetical protein	D2JLE0	Staphylococcus_phage	3.7e-72	100.0
WP_001794311.1\|1487788_1487989_-	DUF1514 family protein	D2JLD9	Staphylococcus_phage	1.4e-28	100.0
WP_000595238.1\|1487988_1488138_-	transcriptional activator RinB	A7TWB4	Staphylococcus_phage	4.8e-18	100.0
WP_000483477.1\|1488130_1488367_-	hypothetical protein	A7TWB3	Staphylococcus_phage	1.9e-37	100.0
WP_000195831.1\|1488391_1488628_-	DUF1381 domain-containing protein	C8CH06	Staphylococcus_phage	1.1e-35	100.0
WP_000185638.1\|1488664_1489192_-	dUTP pyrophosphatase	A7TWB1	Staphylococcus_phage	7.8e-95	100.0
WP_001065062.1\|1489184_1489433_-	DUF1024 family protein	A7TWB0	Staphylococcus_phage	1.8e-38	100.0
WP_001794768.1\|1489425_1489797_-	hypothetical protein	A0ZS31	Staphylococcus_virus	2.9e-64	100.0
WP_001126843.1\|1489805_1490054_-	hypothetical protein	A7TWA8	Staphylococcus_phage	1.0e-41	100.0
WP_001140284.1\|1490054_1490426_-	hypothetical protein	A7TWN6	Staphylococcus_phage	5.0e-56	100.0
WP_001187231.1\|1490426_1490612_-	DUF3113 family protein	A7YGR8	Staphylococcus_virus	2.4e-27	100.0
WP_000049784.1\|1490616_1491021_-	DUF1064 domain-containing protein	A7TWN5	Staphylococcus_phage	7.1e-72	100.0
WP_001123666.1\|1491031_1491253_-	DUF3269 family protein	A7YGR3	Staphylococcus_virus	1.7e-35	100.0
WP_000237153.1\|1491265_1491427_-	hypothetical protein	D2JGK6	Staphylococcus_phage	4.5e-22	100.0
WP_000803065.1\|1491420_1492200_-	ATP-binding protein	W5RAN3	Staphylococcus_phage	1.2e-144	100.0
WP_000190224.1\|1492209_1492980_-	conserved phage C-terminal domain-containing protein	W5R8N2	Staphylococcus_phage	1.4e-116	100.0
WP_000371250.1\|1493044_1493902_+	DUF4393 domain-containing protein	Q4ZBL8	Staphylococcus_phage	9.5e-159	100.0
WP_001199439.1\|1494007_1494679_-	hypothetical protein	A7TWM9	Staphylococcus_phage	2.0e-127	100.0
WP_000704708.1\|1494691_1495243_-	hypothetical protein	W5R977	Staphylococcus_phage	3.4e-101	100.0
WP_001288250.1\|1495272_1496046_-	AAA family ATPase	A0ZS20	Staphylococcus_virus	2.1e-141	100.0
WP_000002519.1\|1496045_1496525_-	siphovirus Gp157 family protein	A0ZS19	Staphylococcus_virus	4.0e-82	100.0
WP_000291065.1\|1496539_1496800_-	DUF1108 family protein	A7YGQ1	Staphylococcus_virus	6.8e-44	100.0
WP_000165368.1\|1496804_1497107_-	DUF2482 family protein	W5RAK4	Staphylococcus_phage	1.1e-45	93.0
WP_001285954.1\|1497201_1497363_-	DUF1270 domain-containing protein	A7TWM3	Staphylococcus_phage	8.6e-21	100.0
WP_000034801.1\|1497374_1497638_-	helix-turn-helix domain-containing protein	A0ZS16	Staphylococcus_virus	3.3e-46	100.0
WP_001038398.1\|1497667_1497886_-	hypothetical protein	A0A068A2A3	Staphylococcus_phage	8.6e-32	100.0
WP_001025595.1\|1497882_1498209_-	hypothetical protein	G4KNN2	Staphylococcus_phage	5.4e-54	100.0
WP_001294156.1\|1498535_1498775_-	hypothetical protein	A0ZS12	Staphylococcus_virus	2.9e-33	100.0
WP_154271314.1\|1498851_1498989_-	hypothetical protein	A0ZS11	Staphylococcus_virus	2.2e-17	100.0
WP_001148617.1\|1499280_1500033_-	phage antirepressor KilAC domain-containing protein	G4KNN1	Staphylococcus_phage	1.1e-139	100.0
WP_000639925.1\|1500048_1500291_-	DUF739 family protein	A0A2I6PDH8	Staphylococcus_phage	2.8e-39	100.0
WP_001083969.1\|1500454_1501171_+	helix-turn-helix domain-containing protein	A0A2I6PDG6	Staphylococcus_phage	2.0e-130	100.0
WP_000755719.1\|1501225_1501660_+	hypothetical protein	A0A2D1G561	Staphylococcus_phage	2.8e-26	100.0
WP_000449656.1\|1501688_1502084_+	hypothetical protein	A0ZS06	Staphylococcus_virus	1.7e-70	100.0
WP_001166482.1\|1502283_1502907_-	hypothetical protein	B7T0F3	Staphylococcus_virus	9.8e-105	99.5
WP_000264191.1\|1503016_1504222_+\|integrase	site-specific integrase	M1RZA8	Staphylococcus_phage	1.0e-222	100.0
WP_041206553.1\|1504264_1506298_-	hypothetical protein	B5WZK7	Staphylococcus_phage	1.1e-38	44.1
1504306:1504334	attR	NA	NA	NA	NA
WP_001794318.1\|1506279_1507227_-	DUF1672 domain-containing protein	NA	NA	NA	NA
WP_000987777.1\|1507478_1509230_-	two-component system sensor histidine kinase SrrB	A0A1V0SGX0	Hokovirus	1.7e-21	33.6
WP_000064079.1\|1509210_1509936_-	two-component system response regulator SrrA	W8CYM9	Bacillus_phage	4.6e-45	43.0

DBSCAN-SWA_7

1567780 : 1576092

Staphylococcus_phage(16.67%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001213908.1\|1567780_1568566_-	metal ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	8.0e-19	28.3
WP_000924211.1\|1568691_1569582_-	deoxyribonuclease IV	A0A2H4UU70	Bodo_saltans_virus	2.0e-26	33.1
WP_001062173.1\|1569591_1570938_-	DEAD/DEAH box helicase	A0A1V0SIR5	Klosneuvirus	1.4e-55	34.0
WP_000683921.1\|1571051_1572152_-	Nif3-like dinuclear metal center hexameric protein	A0A1S5V250	Saudi_moumouvirus	3.0e-08	30.6
WP_000624581.1\|1572154_1572832_-\|tRNA	tRNA (adenine-N(1))-methyltransferase	NA	NA	NA	NA
WP_001283058.1\|1572962_1574069_-	RNA polymerase sigma factor RpoD	A0A2I7SAT0	Vibrio_phage	1.1e-37	38.1
WP_001217253.1\|1574292_1576092_-	DNA primase	A0A0K1LMQ9	Caulobacter_phage	3.5e-54	36.0

DBSCAN-SWA_8

1645530 : 1656494

uncultured_Mediterranean_phage(42.86%)

transposase,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000364542.1\|1645530_1646049_-	adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	5.6e-29	46.5
WP_000595001.1\|1646070_1648344_-	single-stranded-DNA-specific exonuclease RecJ	A7KV88	Bacillus_phage	6.2e-64	29.3
WP_000749802.1\|1648546_1650826_-	protein translocase subunit SecDF	A0A1B1IVP7	uncultured_Mediterranean_phage	1.8e-31	35.8
WP_000277741.1\|1651076_1652723_-\|transposase	IS1182-like element ISSau3 family transposase	A0ZS58	Staphylococcus_virus	3.5e-295	100.0
WP_001160682.1\|1653021_1653282_-	preprotein translocase subunit YajC	A0A1B1IVR5	uncultured_Mediterranean_phage	8.2e-05	35.3
WP_001112045.1\|1653300_1654440_-\|tRNA	tRNA guanosine(34) transglycosylase Tgt	A0A1B1IVQ4	uncultured_Mediterranean_phage	5.4e-85	44.7
WP_001019169.1\|1654462_1655488_-\|tRNA	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	NA	NA	NA	NA
WP_001005767.1\|1655489_1656494_-	Holliday junction branch migration DNA helicase RuvB	B3GAM6	uncultured_virus	1.7e-05	29.1

DBSCAN-SWA_9

1779633 : 1848023

Staphylococcus_phage(93.02%)

tRNA,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001050518.1\|1779633_1785741_-	YSIRK signal domain/LPXTG anchor domain surface protein	A0A2H4PQU6	Staphylococcus_phage	8.7e-222	68.3
WP_000836472.1\|1786064_1786376_-	rhodanese-like domain-containing protein	A0A2H4PQR9	Staphylococcus_phage	4.5e-50	96.1
WP_001794349.1\|1786397_1788815_-\|tRNA	leucine--tRNA ligase	A0A2H4PQS0	Staphylococcus_phage	0.0e+00	98.7
WP_001025064.1\|1789103_1790285_-	MFS transporter	A0A2H4PQR6	Staphylococcus_phage	9.6e-218	99.7
WP_000526541.1\|1790394_1791348_+	TIGR01212 family radical SAM protein	A0A2H4PQV5	Staphylococcus_phage	6.4e-79	99.3
WP_000764425.1\|1791344_1791908_+	class I SAM-dependent methyltransferase	A0A2H4PQV0	Staphylococcus_phage	1.1e-99	95.7
WP_000757543.1\|1792026_1792428_-	MarR family transcriptional regulator	NA	NA	NA	NA
WP_000266096.1\|1793001_1793829_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_014937042.1\|1793831_1793951_-	hypothetical protein	NA	NA	NA	NA
WP_001196350.1\|1794062_1795064_+	proline dehydrogenase	A0A2H4PQT6	Staphylococcus_phage	1.9e-182	98.8
WP_001008553.1\|1795185_1795650_-	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	4.9e-69	98.1
WP_001159032.1\|1795662_1796844_-	3,4-dihydroxy-2-butanone-4-phosphate synthase	A0A2H4PQS2	Staphylococcus_phage	6.6e-227	99.7
WP_000493891.1\|1796854_1797487_-	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	8.4e-112	99.0
WP_000077342.1\|1797493_1798537_-	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	5.9e-195	98.3
WP_001261683.1\|1799017_1800520_-	FAD/NAD(P)-binding protein	A0A2H4PQX2	Staphylococcus_phage	5.0e-30	98.6
WP_000221190.1\|1801161_1801476_+	winged helix-turn-helix transcriptional regulator	A0A2H4PQT4	Staphylococcus_phage	1.3e-52	98.1
WP_000989104.1\|1801475_1802768_+	arsenite efflux transporter membrane subunit ArsB	A0A2H4PQU3	Staphylococcus_phage	2.6e-216	95.1
WP_001032833.1\|1802854_1803709_-	N-acetylglucosaminidase	Q4ZCC7	Staphylococcus_virus	9.8e-39	38.6
WP_000384171.1\|1803984_1804209_-	hypothetical protein	NA	NA	NA	NA
WP_000671059.1\|1804407_1804878_+	RNA polymerase sigma factor	A0A2H4PQT5	Staphylococcus_phage	7.7e-70	85.8
WP_001152695.1\|1804990_1805434_+	competence protein ComK	NA	NA	NA	NA
WP_001045397.1\|1805420_1805864_-	hypothetical protein	A0A2H4PQT8	Staphylococcus_phage	7.1e-49	76.7
WP_001168914.1\|1806161_1806797_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_000492901.1\|1806963_1807584_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_001096494.1\|1807982_1808696_-	transaldolase	M1PR54	Cyanophage	5.5e-19	35.3
WP_000091448.1\|1808954_1809257_+	hypothetical protein	NA	NA	NA	NA
WP_001200542.1\|1809511_1809877_+	fluoride efflux transporter CrcB	A0A2H4PQR0	Staphylococcus_phage	3.6e-59	100.0
WP_000623481.1\|1809873_1810227_+	CrcB family protein	A0A2H4PQQ7	Staphylococcus_phage	4.2e-20	97.4
WP_000453316.1\|1810476_1811310_-	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	1.2e-158	99.6
WP_000366165.1\|1811521_1812430_-	NERD domain-containing protein	A0A2H4PQQ8	Staphylococcus_phage	9.8e-138	99.7
WP_000933819.1\|1812554_1813748_-	methionine adenosyltransferase	A0A2H4PQS6	Staphylococcus_phage	4.3e-218	99.5
WP_000109909.1\|1814119_1815712_+	phosphoenolpyruvate carboxykinase (ATP)	A0A2H4PQN1	Staphylococcus_phage	0.0e+00	99.8
WP_001801476.1\|1816004_1816751_-	S9 family peptidase	A0A2H4PQM6	Staphylococcus_phage	3.3e-139	97.2
WP_000672010.1\|1816755_1817229_-	nucleoside triphosphatase YtkD	A0A2H4PQM4	Staphylococcus_phage	9.5e-84	98.1
WP_000718107.1\|1817294_1817552_+	membrane protein insertion efficiency factor YidD	A0A2H4PQM5	Staphylococcus_phage	7.2e-46	100.0
WP_000778539.1\|1817548_1818550_-	o-succinylbenzoate synthase	A0A2H4PQM0	Staphylococcus_phage	8.5e-183	96.7
WP_000348372.1\|1818554_1820033_-	o-succinylbenzoate--CoA ligase	A0A2H4PQM9	Staphylococcus_phage	2.4e-282	97.2
WP_016186903.1\|1820191_1820647_-	DUF4909 domain-containing protein	A0A2H4PQN7	Staphylococcus_phage	3.5e-75	94.5
WP_001794016.1\|1820949_1821600_+	excalibur calcium-binding domain-containing protein	A0A2H4PQM8	Staphylococcus_phage	1.0e-51	88.4
WP_000070654.1\|1821680_1822676_+	DUF4352 domain-containing protein	A0A2H4PQN2	Staphylococcus_phage	3.8e-74	97.2
WP_000669038.1\|1822751_1823378_+	hypothetical protein	A0A2H4PQM7	Staphylococcus_phage	4.5e-81	84.1
WP_000627550.1\|1823418_1823763_+	DUF3969 family protein	A0A2H4PQN6	Staphylococcus_phage	5.1e-55	94.7
WP_000414222.1\|1823860_1824433_+	hypothetical protein	A0A2H4PQN4	Staphylococcus_phage	3.2e-25	94.8
WP_001093574.1\|1824581_1825949_-	FRG domain-containing protein	NA	NA	NA	NA
WP_000125075.1\|1825948_1826518_-	ImmA/IrrE family metallo-endopeptidase	A0A2H4PQN8	Staphylococcus_phage	2.2e-39	54.8
WP_000747804.1\|1826710_1827157_-	DUF1433 domain-containing protein	NA	NA	NA	NA
WP_001801861.1\|1827607_1827703_+	type I toxin-antitoxin system Fst family toxin PepA1	NA	NA	NA	NA
WP_001791232.1\|1827825_1827927_+	hypothetical protein	NA	NA	NA	NA
WP_001037039.1\|1828101_1828545_-	DUF1433 domain-containing protein	NA	NA	NA	NA
WP_000731421.1\|1828544_1828988_-	DUF1433 domain-containing protein	NA	NA	NA	NA
WP_000182551.1\|1829954_1832375_+	polysaccharide lyase 8 family protein	NA	NA	NA	NA
WP_001036446.1\|1832500_1832878_-	DUF1433 domain-containing protein	NA	NA	NA	NA
WP_000619920.1\|1833087_1833537_-	DUF1433 domain-containing protein	NA	NA	NA	NA
WP_000095390.1\|1835205_1835505_+	WXG100 family type VII secretion target	NA	NA	NA	NA
WP_000028587.1\|1838768_1840325_-	type I restriction-modification system subunit M	A0A2H4PQP4	Staphylococcus_phage	2.2e-286	98.6
WP_001038742.1\|1840687_1841407_-\|protease	serine protease SplF	A0A2H4PQP1	Staphylococcus_phage	1.0e-129	98.3
WP_001038734.1\|1841576_1842293_-\|protease	serine protease SplE	A0A2H4PQN5	Staphylococcus_phage	6.6e-129	97.1
WP_001038730.1\|1842456_1843173_-\|protease	serine protease	A0A2H4PQN5	Staphylococcus_phage	2.4e-86	64.7
WP_001038766.1\|1843339_1844056_-\|protease	serine protease	A0A2H4PQN5	Staphylococcus_phage	5.5e-83	62.6
WP_001039022.1\|1844179_1844899_-\|protease	serine protease SplC	A0A2H4PQP7	Staphylococcus_phage	6.4e-124	93.7
WP_000595635.1\|1845913_1846429_+	membrane protein	NA	NA	NA	NA
WP_000711497.1\|1846676_1848023_+	DUF4041 domain-containing protein	M1NRY5	Streptococcus_phage	6.7e-66	51.3

DBSCAN-SWA_10

1935900 : 2032800

119

Staphylococcus_phage(72.29%)

tRNA,protease,tail,portal,capsid,integrase,terminase,holin,head

attL 1933788:1933807|attR 2026454:2026473

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1933788:1933807	attL	NA	NA	NA	NA
WP_000027924.1\|1935900_1937358_-\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA	NA	NA	NA	NA
WP_000170162.1\|1937359_1937662_-\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	NA	NA	NA	NA
WP_000957023.1\|1938028_1939567_+	sodium/proline symporter PutP	NA	NA	NA	NA
WP_000831695.1\|1939655_1940855_-	CamS family sex pheromone protein	NA	NA	NA	NA
WP_000774552.1\|1940867_1942871_-	NAD-dependent DNA ligase LigA	A0A0K2QQN8	Ralstonia_phage	9.8e-114	36.1
WP_000992924.1\|1942874_1945067_-	DNA helicase PcrA	A7KV33	Bacillus_phage	1.0e-135	42.2
WP_000272063.1\|1945063_1945756_-	heptaprenylglyceryl phosphate synthase	NA	NA	NA	NA
WP_001165363.1\|1945938_1946241_-	hypothetical protein	NA	NA	NA	NA
WP_000572878.1\|1946349_1947645_-	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	1.6e-16	32.9
WP_000827737.1\|1948495_1949662_+\|protease	cysteine protease staphopain A	NA	NA	NA	NA
WP_000434531.1\|1949692_1950016_+	staphostatin A	NA	NA	NA	NA
WP_000669861.1\|1950309_1950483_-	NETI motif-containing protein	NA	NA	NA	NA
WP_000011542.1\|1950463_1951066_-	DUF2179 domain-containing protein	NA	NA	NA	NA
WP_000040861.1\|1951335_1952157_-	ammonia-dependent NAD(+) synthetase	G3MA24	Bacillus_virus	2.3e-69	52.7
WP_000284434.1\|1952149_1953619_-	nicotinate phosphoribosyltransferase	G3MA18	Bacillus_virus	8.5e-107	44.5
WP_000897633.1\|1953802_1954879_+	nitric oxide synthase oxygenase	NA	NA	NA	NA
WP_001177832.1\|1954898_1955693_+	prephenate dehydratase	NA	NA	NA	NA
WP_031788442.1\|1955764_1955872_+	hypothetical protein	NA	NA	NA	NA
WP_000323171.1\|1955882_1957445_-	SLC13 family permease	NA	NA	NA	NA
WP_000275719.1\|1957649_1958747_-	pectate lyase	U5PWM6	Bacillus_phage	8.7e-48	34.6
WP_000149686.1\|1959119_1959680_+	cysteine hydrolase	G3MA16	Bacillus_virus	2.0e-32	41.2
WP_001140871.1\|1959732_1960662_+	manganese-dependent inorganic pyrophosphatase	NA	NA	NA	NA
WP_001790680.1\|1960855_1961029_-	hypothetical protein	NA	NA	NA	NA
WP_001021224.1\|1961080_1962460_+	aldehyde dehydrogenase	NA	NA	NA	NA
WP_000181322.1\|1962579_1963608_-	lactonase family protein	NA	NA	NA	NA
WP_000205106.1\|1963878_1964280_+	YolD-like family protein	U3PG23	Staphylococcus_phage	6.0e-23	42.9
WP_000267034.1\|1964336_1964510_-	hypothetical protein	NA	NA	NA	NA
WP_001188074.1\|1964960_1966001_+	linear amide C-N hydrolase	NA	NA	NA	NA
WP_000713064.1\|1966057_1966900_-	DUF4097 family beta strand repeat protein	NA	NA	NA	NA
WP_001033968.1\|1966896_1967454_-	DUF1700 domain-containing protein	NA	NA	NA	NA
WP_000966289.1\|1967513_1968038_-	hypothetical protein	NA	NA	NA	NA
WP_000182842.1\|1968158_1968722_+	thioredoxin family protein	NA	NA	NA	NA
WP_001221650.1\|1968785_1969526_-	phenol-soluble modulin export ABC transporter permease subunit PmtD	NA	NA	NA	NA
WP_000763048.1\|1969525_1970398_-	phenol-soluble modulin export ABC transporter ATP-binding protein PmtC	A0A2H4PQG7	Staphylococcus_phage	6.1e-28	35.2
WP_000645732.1\|1970394_1971075_-	phenol-soluble modulin export ABC transporter permease subunit PmtB	NA	NA	NA	NA
WP_000991315.1\|1971075_1971972_-	phenol-soluble modulin export ABC transporter ATP-binding protein PmtA	A0A2H4PQG7	Staphylococcus_phage	1.1e-16	30.2
WP_000691584.1\|1971968_1972349_-	GntR family transcriptional regulator	NA	NA	NA	NA
WP_000681966.1\|1972606_1972783_-	hypothetical protein	NA	NA	NA	NA
WP_000990056.1\|1973024_1973123_-	hypothetical protein	NA	NA	NA	NA
WP_001068528.1\|1973322_1974609_+	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_000669728.1\|1974879_1976949_-	extracellular adherence protein Eap/Map	NA	NA	NA	NA
WP_000669789.1\|1977921_1978101_+	hypothetical protein	A0A1W6JQ29	Staphylococcus_phage	2.2e-25	100.0
WP_001791826.1\|1978411_1978672_+	hypothetical protein	M9NS66	Staphylococcus_phage	2.3e-23	100.0
WP_000702263.1\|1978724_1979075_-	complement inhibitor SCIN-A	A0A1P8L6B0	Staphylococcus_phage	7.5e-54	100.0
WP_000727649.1\|1979757_1980207_+	chemotaxis-inhibiting protein CHIPS	A0A1P8L6A8	Staphylococcus_phage	1.1e-78	100.0
WP_000919350.1\|1981285_1981777_-	staphylokinase	A0A1X9H028	Staphylococcus_phage	9.5e-87	100.0
WP_000861038.1\|1981967_1982723_-	CHAP domain-containing protein	D2JLG5	Staphylococcus_phage	3.4e-152	100.0
WP_000611512.1\|1982734_1982989_-\|holin	phage holin	D2JLG4	Staphylococcus_phage	4.1e-41	100.0
WP_001791821.1\|1983040_1983148_+	hypothetical protein	NA	NA	NA	NA
WP_011447039.1\|1983200_1983377_-\|holin	putative holin-like toxin	D2JLG3	Staphylococcus_phage	2.2e-22	98.3
WP_000539688.1\|1983526_1983823_-	DUF2951 domain-containing protein	D2JLG2	Staphylococcus_phage	2.9e-46	100.0
WP_001040261.1\|1983880_1984168_-	hypothetical protein	D2JLG1	Staphylococcus_phage	1.3e-43	100.0
WP_001153681.1\|1984214_1984367_-	hypothetical protein	D2JLG0	Staphylococcus_phage	5.2e-20	100.0
WP_000582165.1\|1984356_1988142_-	hypothetical protein	A0A1X9H0H3	Staphylococcus_phage	0.0e+00	98.5
WP_000567408.1\|1988157_1989642_-\|tail	phage tail family protein	A0A2I6PDJ0	Staphylococcus_phage	1.2e-297	100.0
WP_001794405.1\|1989638_1994168_-\|tail	phage tail tape measure protein	Q6R868	Staphylococcus_virus	0.0e+00	97.3
WP_001549167.1\|1994224_1994362_-	hypothetical protein	A0A2I6PDX7	Staphylococcus_phage	3.4e-18	100.0
WP_001096355.1\|1994412_1994763_-	hypothetical protein	G4KNQ8	Staphylococcus_phage	7.8e-59	100.0
WP_071621395.1\|1994812_1995037_-	Ig-like domain-containing protein	A0A075LYE8	Staphylococcus_phage	3.0e-32	100.0
WP_000268736.1\|1995078_1995723_-\|tail	phage tail protein	Q6R871	Staphylococcus_virus	6.5e-120	100.0
WP_000565498.1\|1995723_1996131_-	hypothetical protein	G4KNQ6	Staphylococcus_phage	7.1e-72	100.0
WP_000114341.1\|1996127_1996532_-	HK97 gp10 family phage protein	A0A1W6JPJ1	Staphylococcus_phage	2.5e-69	100.0
WP_000755150.1\|1996528_1996891_-\|head,tail	head-tail adaptor protein	G4KNQ4	Staphylococcus_phage	4.4e-65	100.0
WP_000150936.1\|1996874_1997159_-\|head,tail	phage head-tail adapter protein	A0A2I6PDJ5	Staphylococcus_phage	2.3e-45	100.0
WP_000238240.1\|1997148_1997433_-	hypothetical protein	A0A1W6JPL8	Staphylococcus_phage	2.3e-45	100.0
WP_000154552.1\|1997452_1998598_-\|capsid	phage major capsid protein	C8CH21	Staphylococcus_phage	7.3e-215	100.0
WP_000642728.1\|1998621_1999359_-\|protease	Clp protease ClpP	G4KNQ2	Staphylococcus_phage	1.8e-129	100.0
WP_000025266.1\|1999342_2000530_-\|portal	phage portal protein	A0A2I6PDI1	Staphylococcus_phage	3.0e-219	99.7
WP_000625096.1\|2000545_2002207_-\|terminase	terminase large subunit	A0A075M4D3	Staphylococcus_phage	0.0e+00	100.0
WP_000402904.1\|2002203_2002548_-	hypothetical protein	G4KNP9	Staphylococcus_phage	9.4e-57	100.0
WP_000988336.1\|2002677_2002977_-	HNH endonuclease	A0EWY8	Staphylococcus_phage	4.6e-52	100.0
WP_000590122.1\|2003208_2003625_-	hypothetical protein	G4KNP7	Staphylococcus_phage	1.3e-76	100.0
WP_000265043.1\|2003652_2003853_-	DUF1514 family protein	A0A2I6PDV9	Staphylococcus_phage	1.4e-28	100.0
WP_000595265.1\|2003852_2004002_-	transcriptional activator RinB	A0A1W6JPZ2	Staphylococcus_phage	4.8e-18	100.0
WP_000592207.1\|2003998_2004385_-	hypothetical protein	W5R986	Staphylococcus_phage	3.0e-64	100.0
WP_000195803.1\|2004381_2004588_-	DUF1381 domain-containing protein	A0A0H3U2R7	Staphylococcus_phage	1.3e-29	100.0
WP_000185695.1\|2004624_2005161_-	dUTP diphosphatase	A0A1P8L6E0	Staphylococcus_phage	7.9e-95	99.4
WP_000714405.1\|2005153_2005324_-	hypothetical protein	A0A0H3U4U6	Staphylococcus_phage	4.1e-21	96.4
WP_001065126.1\|2005310_2005565_-	DUF1024 family protein	A0A0H3U469	Staphylococcus_phage	1.4e-38	98.8
WP_000193482.1\|2005557_2005989_-	hypothetical protein	Q4ZBT4	Staphylococcus_virus	3.4e-72	96.5
WP_000979207.1\|2005985_2006369_-	hypothetical protein	D2JGL4	Staphylococcus_phage	4.3e-26	54.8
WP_000983948.1\|2006368_2006560_-	hypothetical protein	Q4ZDX2	Staphylococcus_virus	6.2e-26	95.2
WP_000694060.1\|2006556_2006982_-	hypothetical protein	B7T0H5	Staphylococcus_virus	2.6e-56	81.0
WP_001126837.1\|2006996_2007245_-	hypothetical protein	A0A2I6PDI0	Staphylococcus_phage	9.4e-43	98.8
WP_001140295.1\|2007245_2007617_-	hypothetical protein	C5I648	Staphylococcus_phage	1.5e-55	96.7
WP_001187241.1\|2007617_2007803_-	DUF3113 family protein	A0A2H4PQI8	Staphylococcus_phage	7.8e-26	95.1
WP_000049776.1\|2007807_2008212_-	DUF1064 domain-containing protein	Q6R835	Staphylococcus_virus	5.1e-70	97.8
WP_001123683.1\|2008221_2008443_-	DUF3269 family protein	A0A2H4PQI9	Staphylococcus_phage	2.1e-33	95.9
WP_000237154.1\|2008456_2008618_-	hypothetical protein	A0A0H4IU12	Staphylococcus_phage	1.0e-21	100.0
WP_000803046.1\|2008611_2009385_-	ATP-binding protein	A0A2H4PQI3	Staphylococcus_phage	5.1e-143	99.2
WP_000504988.1\|2009394_2010198_-	phage replisome organizer N-terminal domain-containing protein	A0A2H4JCF5	uncultured_Caudovirales_phage	1.1e-121	100.0
WP_001199441.1\|2010950_2011616_-	hypothetical protein	A7TWM9	Staphylococcus_phage	1.1e-125	100.0
WP_000704713.1\|2011628_2012183_-	single-stranded DNA-binding protein	A7TWM8	Staphylococcus_phage	1.0e-100	100.0
WP_000139741.1\|2012212_2012992_-	ATP-binding protein	Q9G028	Staphylococcus_virus	7.4e-142	99.6
WP_000815401.1\|2012984_2013206_-	DUF2483 family protein	A7TWM6	Staphylococcus_phage	3.2e-34	100.0
WP_001794414.1\|2013215_2013476_-	DUF1108 family protein	G4KNN5	Staphylococcus_phage	9.9e-43	98.8
WP_000829613.1\|2013480_2013798_-	hypothetical protein	Q4ZAS8	Staphylococcus_virus	3.9e-33	100.0
WP_000066016.1\|2013886_2014048_-	DUF1270 family protein	Q4ZAZ7	Staphylococcus_virus	1.2e-19	98.1
WP_001120198.1\|2014044_2014365_-	DUF771 domain-containing protein	A0A2I6PDH6	Staphylococcus_phage	5.6e-56	99.1
WP_000275058.1\|2014423_2015056_+	hypothetical protein	A7TW95	Staphylococcus_phage	1.5e-113	100.0
WP_000939496.1\|2015070_2015211_-	hypothetical protein	A0A2I6PDG0	Staphylococcus_phage	1.9e-16	100.0
WP_001148861.1\|2015241_2015439_-	hypothetical protein	A0A1W6JPV3	Staphylococcus_phage	1.2e-24	100.0
WP_001148647.1\|2015454_2016207_-	phage antirepressor KilAC domain-containing protein	A0A0E3T9K5	Staphylococcus_phage	3.1e-137	98.8
WP_001794416.1\|2016236_2016458_-	helix-turn-helix transcriptional regulator	Q4ZB05	Staphylococcus_virus	2.3e-32	94.4
WP_000901359.1\|2016612_2017245_+	helix-turn-helix domain-containing protein	Q4ZB06	Staphylococcus_virus	1.4e-103	90.9
WP_000837517.1\|2017425_2018124_+	potassium channel family protein	A0A1B0Y2S3	Lactobacillus_phage	4.4e-13	29.8
WP_000694772.1\|2018279_2018462_+	hypothetical protein	A0A2I6PDF8	Staphylococcus_phage	6.9e-27	100.0
WP_001286807.1\|2018597_2020256_+	Dam family site-specific DNA-(adenine-N6)-methyltransferase	A0A2H4JAL2	uncultured_Caudovirales_phage	1.7e-257	81.7
WP_000857187.1\|2020311_2021337_+\|integrase	site-specific integrase	A0A0H3U2W9	Staphylococcus_phage	2.3e-175	99.1
WP_000595617.1\|2022485_2023505_-	leukocidin/hemolysin toxin family protein	A0A2I6PEU3	Staphylococcus_phage	3.4e-54	39.6
WP_000791398.1\|2023526_2024582_-	leukocidin family pore-forming toxin	A0A2I6PER8	Staphylococcus_phage	7.9e-38	34.6
WP_000206618.1\|2025013_2026237_+	ArgE/DapE family deacylase	NA	NA	NA	NA
WP_001045062.1\|2026675_2027983_+	TrkH family potassium uptake protein	NA	NA	NA	NA
2026454:2026473	attR	NA	NA	NA	NA
WP_001573771.1\|2028560_2028902_-	hypothetical protein	C8CH40	Staphylococcus_phage	4.1e-20	46.0
WP_025173856.1\|2028891_2029188_-	hypothetical protein	C8CH40	Staphylococcus_phage	3.3e-10	39.4
WP_000201397.1\|2029184_2029364_-	hypothetical protein	NA	NA	NA	NA
WP_000240651.1\|2029905_2031522_-	chaperonin GroEL	A0A240F779	uncultured_virus	2.6e-157	54.7
WP_000917289.1\|2031597_2031882_-	co-chaperone GroES	A0A221S386	uncultured_virus	4.7e-14	46.2
WP_000197638.1\|2032056_2032800_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_022126

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NC_022113

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection