CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_014623	Stigmatella aurantiaca DW4/3-1, complete sequence	9 crisprs	cas6,DEDDh,DinG,csa3,RT,WYL,PD-DExK,cas4,2OG_CAS,cas3	2	1	8	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_014623_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014623_1

295868-295964

Unclear

Consensus_repeat	Method
TTGCCGTTGATGTCCGGGCGGGGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014623_1

>merge|NC_014623|1|295868-295964|CRISPRCasFinder
TTGCCGTTGATGTCCGGGCGGGGCGAGAAGTCAGGTTTGGACGGGGTGTTGGGCTTGTTGGCGCCGGGCTTGTTGCCGTTGATGTCCGGGCGGGGCG

>NC_014623|1|1|295868-295964|CRISPRCasFinder
TTGCCGTTGATGTCCGGGCGGGGCG	AGAAGTCAGGTTTGGACGGGGTGTTGGGCTTGTTGGCGCCGGGCTTG
TTGCCGTTGATGTCCGGGCGGGGCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_014623.1\|WP_081465983.1\|310653_311985_+\|IS4-family-transposase	unknown	unknown	gnl\|CDD\|376573
NC_014623.1\|WP_002611633.1\|307543_310123_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227511
NC_014623.1\|WP_002611665.1\|286760_289979_+\|type-2-lantipeptide-synthetase-LanM	unknown	unknown	gnl\|CDD\|274840
NC_014623.1\|WP_002611602.1\|292899_293280_-\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|197609
NC_014623.1\|WP_002611628.1\|301797_302685_-\|NAD(P)H-binding-protein	unknown	unknown	gnl\|CDD\|187542
NC_014623.1\|WP_002611603.1\|286347_286641_+\|mersacidin/lichenicidin-family-type-2-lantibiotic	unknown	unknown	gnl\|CDD\|274841
NC_014623.1\|WP_002611669.1\|303701_306404_-\|AsmA-family-protein	unknown	unknown	gnl\|CDD\|282957
NC_014623.1\|WP_002611658.1\|293823_295116_-\|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|379799
NC_014623.1\|WP_049805100.1\|292238_292949_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|381597
NC_014623.1\|WP_002611645.1\|302681_303137_-\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|226158
NC_014623.1\|WP_002611640.1\|290211_290520_+\|STAS/SEC14-domain-containing-protein	unknown	unknown	gnl\|CDD\|378774
NC_014623.1\|WP_157601277.1\|291880_292030_-\|hypothetical-protein	unknown	unknown	unknown
NC_014623.1\|WP_148273548.1\|306758_307544_+\|hypothetical-protein	unknown	unknown	unknown
NC_014623.1\|WP_086016051.1\|297148_298114_-\|DNA-cytosine-methyltransferase	unknown	unknown	gnl\|CDD\|365904
NC_014623.1\|WP_148273547.1\|303298_303658_+\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
NC_014623.1\|WP_013374053.1\|299939_301811_+\|erythromycin-esterase-family-protein	unknown	unknown	gnl\|CDD\|350610
NC_014623.1\|WP_002611630.1\|296324_297038_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226570
NC_014623.1\|WP_002611651.1\|293325_293796_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NC_014623.1\|WP_002611617.1\|284638_286234_+\|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl\|CDD\|223910
NC_014623.1\|WP_002611627.1\|290575_291778_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225097

Protein	Function_ID	Function_description	E-value
NC_014623.1\|WP_002611669.1\|303701_306404_-\|AsmA-family-protein	gnl\|CDD\|282957	pfam05170, AsmA, AsmA family. The AsmA gene, whose product is involved in the assembly of outer membrane proteins in Escherichia coli. AsmA mutations were isolated as extragenic suppressors of an OmpF assembly mutant. AsmA may have a role in LPS biogenesis.	8.15194e-13
NC_014623.1\|WP_081465983.1\|310653_311985_+\|IS4-family-transposase	gnl\|CDD\|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	3.44908e-06
NC_014623.1\|WP_002611633.1\|307543_310123_+\|hypothetical-protein	gnl\|CDD\|227511	COG5184, ATS1, Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton].	3.28733e-59
NC_014623.1\|WP_002611665.1\|286760_289979_+\|type-2-lantipeptide-synthetase-LanM	gnl\|CDD\|274840	TIGR03897, Lantibiotic_mersacidin_modifying_enzyme, type 2 lantibiotic biosynthesis protein LanM. Members of this family are known generally as LanM, a multifunctional enzyme of lantibiotic biosynthesis. This catalysis by LanM distinguishes the type 2 lantibiotics, such as mersacidin, cinnamycin, and lichenicidin, from LanBC-produced type 1 lantibiotics such as nisin and subtilin. The N-terminal domain contains regions associated with Ser and Thr dehydration. The C-terminal region contains a pfam05147 domain, which catalyzes the formation of the lanthionine bridge. [Cellular processes, Toxin production and resistance].	0
NC_014623.1\|WP_002611602.1\|292899_293280_-\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|197609	smart00257, LysM, Lysin motif.	5.21331e-17
NC_014623.1\|WP_002611603.1\|286347_286641_+\|mersacidin/lichenicidin-family-type-2-lantibiotic	gnl\|CDD\|274841	TIGR03898, hypothetical_protein_SrosN15_20203, type 2 lantibiotic, mersacidin/lichenicidin family. This model recognizes a number of type 2 lantibiotic-type bacteriocins, including mersacidin and lichenicidin. Members often are found as gene pairs encoding two-chain bacteriocins. Maturation is accomplished, at least in part, by a LanM-type enzyme (TIGR03897). This model describes only the leader peptide region. [Cellular processes, Toxin production and resistance].	1.76586e-16
NC_014623.1\|WP_148273547.1\|303298_303658_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	1.06836e-38
NC_014623.1\|WP_002611658.1\|293823_295116_-\|SGNH/GDSL-hydrolase-family-protein	gnl\|CDD\|379799	pfam16227, DUF4886, Domain of unknown function (DUF4886). This domain is mainly found in uncharacterized proteins around 290 residues in length and is mainly found in various Bacteroides species. It has a curved central beta sheet flanked by helices. Distant homolog analysis showed it has a similarity with GDSL-like Lipase/Acylhydrose family. The function of this domain is still unknown.	3.33553e-08
NC_014623.1\|WP_049805100.1\|292238_292949_-\|hypothetical-protein	gnl\|CDD\|381597	cd00735, T4-like_lys, bacteriophage T4-like lysozymes. Bacteriophage T4-like lysozymes hydrolyze the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) in peptidoglycan heteropolymers of prokaryotic cell walls. Members include a variety of bacteriophages (T4, RB49, RB69, Aeh1), as well as Dictyostelium.	2.44204e-07
NC_014623.1\|WP_002611645.1\|302681_303137_-\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|226158	COG3631, COG3631, Ketosteroid isomerase-related protein [General function prediction only].	2.4065e-14
NC_014623.1\|WP_002611640.1\|290211_290520_+\|STAS/SEC14-domain-containing-protein	gnl\|CDD\|378774	pfam11964, SpoIIAA-like, SpoIIAA-like. These proteins adopt an alpha/beta SpoIIAA-like fold, similar to that found in STAT (pfam01740). They adopt open and closed conformations arising from different arrangements of their alpha-2 and alpha-3 helices. They may be membrane associated and may function as carriers of non-polar compounds.	0.00220924
NC_014623.1\|WP_002611628.1\|301797_302685_-\|NAD(P)H-binding-protein	gnl\|CDD\|187542	cd05231, NmrA_TMR_like_1_SDR_a, NmrA (a transcriptional regulator) and triphenylmethane reductase (TMR) like proteins, subgroup 1, atypical (a) SDRs. Atypical SDRs related to NMRa, TMR, and HSCARG (an NADPH sensor). This subgroup resembles the SDRs and has a partially conserved characteristic [ST]GXXGXXG NAD-binding motif, but lacks the conserved active site residues. NmrA is a negative transcriptional regulator of various fungi, involved in the post-translational modulation of the GATA-type transcription factor AreA. NmrA lacks the canonical GXXGXXG NAD-binding motif and has altered residues at the catalytic triad, including a Met instead of the critical Tyr residue. NmrA may bind nucleotides but appears to lack any dehydrogenase activity. HSCARG has been identified as a putative NADP-sensing molecule, and redistributes and restructures in response to NADPH/NADP ratios. Like NmrA, it lacks most of the active site residues of the SDR family, but has an NAD(P)-binding motif similar to the extended SDR family, GXXGXXG. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Atypical SDRs are distinct from classical SDRs. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	8.92743e-108
NC_014623.1\|WP_002611627.1\|290575_291778_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|225097	COG2186, FadR, Transcriptional regulators [Transcription].	4.58438e-17
NC_014623.1\|WP_013374053.1\|299939_301811_+\|erythromycin-esterase-family-protein	gnl\|CDD\|350610	cd14728, Ere-like, Erythromycin esterase and succinoglycan biosynthesis related proteins. This group contains erythromycin esterase, which shares conserved active site residues of the Tiki/TraB family. Erythromycin esterases (EreA and EreB) disrupt erythromycin via the hydrolysis of the macrolactone ring. A critical catalytic histidine acts as a general base in the activation of a water molecule. Macrolides act by inhibiting bacterial protein synthesis by binding at the exit tunnel of ribosomal subunit 50s, blocking the translation of the polypeptide. Erythromycin esterase, typically found in integrons and transposons, confers antibiotic resistance through the disruption of the drug ring structure. EreB substrate profile is substantially broader than that for EreA, being able to also metabolize semisynthetic derivatives such as azalide azithromycin.	1.3751e-107
NC_014623.1\|WP_002611630.1\|296324_297038_-\|hypothetical-protein	gnl\|CDD\|226570	COG4085, COG4085, Predicted RNA-binding protein, contains TRAM domain [General function prediction only].	0.000111353
NC_014623.1\|WP_002611651.1\|293325_293796_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	6.38523e-12
NC_014623.1\|WP_002611617.1\|284638_286234_+\|methyl-accepting-chemotaxis-protein	gnl\|CDD\|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	3.76725e-51
NC_014623.1\|WP_086016051.1\|297148_298114_-\|DNA-cytosine-methyltransferase	gnl\|CDD\|365904	pfam00145, DNA_methylase, C-5 cytosine-specific DNA methylase.	3.7637e-87

>NC_014623.1|WP_002611658.1|293823_295116_-|SGNH/GDSL-hydrolase-family-protein
MRSAPAVLLAFLLLVVSGPLLAAPPAPAEPPAPRPLRVLFIGNSYTYNNNLPALLEGLARSATPPLRVQTRAIARAGVRLQQHWDRGEALAALRQGSWDYVVLQEQSTLGLRLIDGRHVVNDPELTFHPYARRFAEEARKVGAQPLFLLTWARRNTPESQAQLTQAYMSVARDLGAPIVPAGLAWSRIRQEFPELVLYHPDGSHPSPAGSYLTAVSLYATLTGNSPVGLASLLSGHPSPEGVLDPSRTVTLASLPPEDAERLQRAAWATFEELRQSGGYVTGEPLPPEPLPSLPEGQPLEPATLLGTWRGEMRFYSEEAGQSPATLQLVLRPQGSGLGGTARIVFANGKSEGPFALEQLAVEPARLRFTTPVLSQGRGRVEHEAVLTEEGMTGRALYENPRNHDRYVGTWKLLRPAPPAPAPQAPSPPRE
>NC_014623.1|WP_002611651.1|293325_293796_-|GNAT-family-N-acetyltransferase
MRVLEIAWSHPAGEALRARQRAEIAQRYQRDDSEPGKPPSAEDISVFVLAEDAQGTPLGCGGLRHLGGPTAEVKRMYVVPEARGQGAAVAILRALETWALDRGWTTLRLETGTLQPEAIRFYTREGYARIPNFGPYEGEPLSLCFERHLSSKARTL
>NC_014623.1|WP_002611602.1|292899_293280_-|LysM-peptidoglycan-binding-domain-containing-protein
MDGIEYRVQSGDTLSSIARRHQVTEAVLSRLNGISDVNRIWAGQVLRIPKERPCPTPRAPVHKVCAGETLSGIAEHYHRGPSEGQGHWQPGGNPPHQQGLYRHGEARHGGDGTQADRLRARPLPGE
>NC_014623.1|WP_049805100.1|292238_292949_-|hypothetical-protein
MGHRLTASERARYQVNDRVPLSVLKDWARADVQGAYDAAVAQATMAKAGNQTLVNALACVNFQLGTAWYTEHKKTWACIMAHKWEEAAAEAADSRWYKQTPVRVEDFQAALRAMGGAPLPPGNGASPAASGPDLKDIAHHVRDALDRVFTDEETVYTNLAKLNHDPALIGRFKTLYKTTYQVDVVVDPRVRPVCLGLQSQPPECGGKAQGRQGGQNRNGRSVRQVHGPHAEIAQVR
>NC_014623.1|WP_157601277.1|291880_292030_-|hypothetical-protein
MVVADGLTDRTGQKYTAEFCLQSYQWAIGFVPSTEPLQLTSKDLPSQSL
>NC_014623.1|WP_002611627.1|290575_291778_-|GntR-family-transcriptional-regulator
MEWVGLVGQVEQDLERVISQGLLPQDGFLPSENSLAKHYGLSRSTVREALKRLAARALIEQHPGRRSRALPLEGAVTLENLGVVLEGPGAAQPERRKLLEGFLALKRETAVELLAACCQQASARDLDSLAGLCFELAEEARWGEHPGRWAELEFALLRQAARAVERPGQALLLQSLERSYRGMARRLVPHLNAQATRQWALCALHALAAKDAQPLRQELPALLQASDAHLLAGLPPPQEPRESSLSPLCADTVPSHPTPEHEDATQRLSEANGPNQSACQTGLSQRAPTGGSPPVAPSFDSRPPPVDGAPGTDMPQGQEGSRRVPPGLQERPSQAPVGSDSGVRPLSREGGHLLLYGTAEGEQGGVCTAEEAGPVTGHRVPVEGQDGAGAAGARGRSSPC
>NC_014623.1|WP_002611640.1|290211_290520_+|STAS/SEC14-domain-containing-protein
MILPVQEFKKRHDTLYLLMDAREGTGFTAEARRALNDDRSLIPYAGAVFFGASFAMRAIANMMSRAGTLMGHPPAYPTVFTTTEEEARAWISAHRATRAQGR
>NC_014623.1|WP_002611665.1|286760_289979_+|type-2-lantipeptide-synthetase-LanM
MHTLSPELSWRKAAFLHERAAPGRAAPPEEGAALQHAQRRARAWRQVMSADERLLEERLRSAGLDREGFLQILAHAEGGGDPSQHPSWEGLLQEVLEDRAVNEPLPSFLAAPVSASGPGLPFSGFLHPFLRLGAARLRAGLEALGARVPSPLPLVAPGIDALLLGGLAAQLHELASRVLILELNVARLMDRLQGSTPQERFHHFSTGVLGAADTRAALLEEYPVLARLMATLLERWLETGLEFLAHLAEDRARLEETFLEGRALGPLVALQGGVSDLHRGGRGVFLLQFGSGLRLVYKPKSLAVDRQFQQLLRGLNGAGLRHPHRVLTVLDRGGHGWVEFVEAGGCDSREALQRFYWRQGSFLAVLHLLSAVDFHLENLIAAGEFPVGVDLEALFHHRPPLGPSGKAYGRAWALLDQSIVAVGMLPISLFGRPGRAGLDMSGLGGEAGQLTPQRMPTLEDSGSDTMRVVRRQGRMEGSRNRPRLGAAPVDPTEFTEELIQGFEETHALLIRQREALIPQLRAFAGVEVRYIARATQRYAMLLQESHHPDFLRDGLERDKVLDHLWAEAVHVPLLRRLLPFEHADLRLGDIPFFTARPGERHLWSSTGECIPDFFTQDSLGDVLRRLDRMDAEDCALQVSFIRKAMVSLDKGRAPARALAAPAGEEPLPMATPEECLAAAVAIGERLAAKAIRGDRDVSWIGLNLEDLQQWRWSLSPLGTELYEGLGGLALFFAHLAARTGRADFEALARAALEPVREDWRKLGQHGGTEVGVFVGRGAAVYVLGHLAALWKEPFLRDELREGLPALEALIETDTRLDLLSGAAGLAVALLGLYRTTGEARWREAARRCGERLVATATPQPGGGVGWKGEVGMQPLAGFSHGVAGIAWALLELAEATEDPRYADLAHRGLAYERSLFVPERGQWKDLRAPDTEGHFMAMWCHGASGIALGRLLALRHLEGAEVREELSTALETTLRTGFGGNHSLCHGDMGNLEVLHLAGTVLGERQWTQAALRCATAVLRQGREEDWRCGLPRGSESPGLLMGLSGIGYGLLRLSAPGHVPSILSLASPTGE
>NC_014623.1|WP_002611603.1|286347_286641_+|mersacidin/lichenicidin-family-type-2-lantibiotic
MKRETIIRAWKDPEFRAGLTSDERAALPGCPAGQAFTELDERELEDATGGALALNFEDGCICSNWTVPTKFTTSRTIVINPVDQISLPQLALAGLQR
>NC_014623.1|WP_002611617.1|284638_286234_+|methyl-accepting-chemotaxis-protein
MRLTFKHKMLLLPAGTAVLLLILLIVSLTLLIWTRQVHARIDKGHAPALANSHVLITELESFHRGVLDAVARKDASRLDPLRALGRKIAADLNDTGQNPVTSAPYLEVLQKDFGQYQQESWRAVELGLKGDAQAEVALSRETTRFESLQKALLLFQSEHEQGQEKALQQARTLNSRGQAVQALLAVLCLGWLAAGTWWVVRQVVEPLGRLSDTASRIAESGDLTLAIESHAKDEVGQLGRSLEALVNRLRSVPVGLQAVVGELSTAAERLTKVSQEQLNFLTEQARSLSEAGSTMAEIAQTSSMASSRAEMVLKVAEQADSFTVESQKSIEQSAQGLEQIRQRVSALVGNIGQLSEQAVHAREIIGSVKDLADQSNVLALNAAIEAARAGEGGRGFAVVAREMRALSGQSLQSTERIGKILLDINQAIRTTVSSAEGDSQQMEEGIEQVLSSADKLKEITTVMQESSKAARQIVASVTQQNAGIHQMMEAMQQLSGMMGDVVLATSTAEETVGQINSTVSQLQKIVSEFRV
>NC_014623.1|WP_002611630.1|296324_297038_-|hypothetical-protein
MTSSPFFGRFPRFSSSSRLPFLLLGLTLAAWLAGCGDDEDGQLPKPVSIAEARGRNIGSTVTLQGFVTVQPGAFQSAIGDNGFALQDRTAGIYVKLEQKLNFGLGTQIRVQGTVDEQNGLRILKALPSQVEQIPGTQIIEPRTVRTGEVNESTEGLLVQVTGNVTQVFRDDSPYGYELFINDGSGETQIYVHLTAGFDRATLEALQAGQSITVVGLTAQYETQYEVAPRQPSDLKTN
>NC_014623.1|WP_086016051.1|297148_298114_-|DNA-cytosine-methyltransferase
MTAIEICAGAGGQAIGLDMAGFEHVAAVEIDKHACATLRLNRPQWRVFEEDLKDFSGSSFRGVDLLAGGVPCPPFSIAGKQLGADDERDLFPEALRLVEEIRPAAVMLENVRGLAAERFSEYRASVLSRLERLGYVPSWRVLNASDYGVPQLRPRFILVALRPVAATHFIWPKAQREIPTVGNTIGDLMAAGGWPGADAWVAGAQALAPTIVGGSKKHGGPDLGPTRARLEWSKLGVDGLGIANAAPDAAFPPGQKPKLTVPMVARLQGFPDDWKLSGGKTAAYRQVGNAFPPPVARAVGLCLRKALVKAQAEAPAQLRFA
>NC_014623.1|WP_013374053.1|299939_301811_+|erythromycin-esterase-family-protein
MRIHPWLWLSLGLGCASARPGPVPSPVVSQVRAPLLGQVLGAEGATLPGARITVVPRAPSWDVRTDAPVALTLSGPEGRFEVASLPPGAYGLTAVTPGGVLIVGEPLKVEAGQPVRPIELREGSESPGLLEGTVVDEVGAPVPGAKLRIVRPGMPFDDVALLEASPEGRFRVRSGGGAHNVVASAPGFTPLMQQVAKTGEPVTMRLERAADETMSRAAVAWMKETGVPLKSVEAGQGLEDLAPLKQVLKDTRVVALGEATHGTREFFQLKHRMLEFLVTELGFTVFALEENFAEALAFNEYILEGRGDPRHLLRGSAWDTEEVLALIQWMRRYNEEPSHPKKLKFYGVDMQFSPEAVARVNAYLAQVDAAYGAQVQEPLAVLALPRSGFSRQPEERQKEVGARLDLLAQRFEAERARYVRQSSAAEWAVARQNVRVLRQFVGKVLQEEEELRDRAMAENLLWILEHEGPDTRAVLWAHNGHVQRGPGEWREHAAGRHLADALGPSLYVFGMAFHQGAFLAFNMDAQPPPGRKGMVAFSVPPEPEDTLDAALAATGWPVFALDLRALPRAGPAYEWWRRSRRAHDIGFIYSDGGYPSLAQIHALRLYDGLLFVERTTAARLNPR
>NC_014623.1|WP_002611628.1|301797_302685_-|NAD(P)H-binding-protein
MKLLVTAASGNIGSRVAEQIVAAGAEAVLLSRHPAKLSALSARGAQVLPIGSDDAPGLLSAAQGADALFFLAPPNPGAKDLRDWYTQTATAAAQAVREHRIPRVVCISTVGAHANAPLGTIAFAAEMEERFNRAAPHVLHLRPGYFMENCLSQVESIRHGVLSFPYAEDHDMPWISTDDIGDVAAKYLLDGSWTGHWTRNLLGPENLTLPEVAARISQVAGKPIRYVQVSPEAVQHQLEAQGVNPTVRQQLGDLFRALGDPNGIYATARTPEAFTPTTFETFARNKLLPLLATGG
>NC_014623.1|WP_002611645.1|302681_303137_-|nuclear-transport-factor-2-family-protein
MQTPLSGKAEELFAAHLALVTKDMPAWLELFAENAVIEFPYAPSVGTPARLEGKAAITAYAQGVSSVMRDFVFSDLRVFPAREPHVLFAEVHGEATLPRTGRPYVQDYVMRLETDGERIIHYREYWNPVPVLQAFEGMPGVVDAFHPGGRT
>NC_014623.1|WP_148273547.1|303298_303658_+|winged-helix-turn-helix-transcriptional-regulator
MLVKDVFDETCIVNQALVLLADKWALLVLIVLMQGTKRYSELQRQIRGVSPKMLTQTLRSLEENELVARQVFPEVPPRVEYSLTAFGKSLSHPLAALCDWAFEHEPRLRKVYAQARPAP
>NC_014623.1|WP_002611669.1|303701_306404_-|AsmA-family-protein
MEARKKRRWPYVLGGIFAVLVLGVAIVLWRLDAILLQQARAQAATFSQQLGRPIQIGDISTKLFPHIGVDVENVSVGAAEGEDLPLAEVKALDVRVAAMPLLRSSGKDIQVLNAEVTGLTVNVIRLPDGTTNVQRLQERLASQQKPEEEAPPENTPPTDLSGVRVDRAALTDGTIRFVDRSGAKAQELAVSDLDIEVKDLRVGQPLEVKLAAAVLAQKQNLFVTLSASPLPPTLVPTPERLSLKAEAIDLAPLGPFLPPSVGFQAGTLTADWKAELGAAIPGGKGPTRLEGAIRALGLKFAGAEGGKALDVVLDTDVKADLAAGDLALDRFKLDFGPAGIDGKGRVKGMHGSTPSVEGFELTSHDLDPAVLSDYYPPLKKMLGGMIAGPVGLSVKGSGTQEAQALEAEVDLTPVRLRIPAQLSKEAGAAMRLTARLAGAAASGGALRFDAKANLAGVDMRPGLVLNKAPGQRLDAAVAGTYQPTQDGMKVNVSQLTLNVLADTLTGTATAALAGQGKKQTTTFALDMKSPRIDADALLMPEEEVLARTGGKEEPPSDDATRFNGYRGDMKFQVGAVRYSQMDLSNIVAHVTMVDDLIQVEKLTTGIYGGSVVADGTSIRLGPLPEQRPFEAKVKVQGVEMGSALSAFTPKKVMTGTFNGNVDVKGVGYTPGQLKQTLLGAINGNVANGSLLGLDIISSVTEPLAKALPFAAKALRSGDVTSLGENLPFGVEIKNGVAQLDKPITWSRPEGAMNFTGGIRLDGELDLSGTVNLAPQTIQTLTLGKAKPTEAIPVTLNLTGPAWSPKVTGLDVKPAATAIAKQVVGGLAGQLLGDKAKPVQDLITGGGQAAREEAERQKQALEQKAAEEKARLDAAARAKQEEAKKKAEEEAKKRLRGVFGK
>NC_014623.1|WP_148273548.1|306758_307544_+|hypothetical-protein
MILLLLGIIPSTVRAEGAAEVQTYLLSIQRLFDDLEYERALSEIQLARQVPHGTDEEVTLTLYEGILQYELGQQEQGKAAFKSALSLRPEAKLPVQVAPKVKSLFESVRQQVNQEMASLRAQREAERLKAEAAAPALPPPALPSATVSEEVQPRRDLRRYALVPAIAGGALAIAGGIAWGISRGELNQLRNDDPKLATMEDVQQSISRGRTWQTVGVSLLSVGAAGLAAATGMYVLGGPDKPVALSVGTTGTSAVIQGRWP
>NC_014623.1|WP_002611633.1|307543_310123_+|hypothetical-protein
MKPRKTGTLQAVLATVLLAWVGGCSDFDEEGAAFCQRNPSRCGVDTTAPVITQSSQSAPGVQVQGPVTLSVTAQDDETPQLTFSWTANVGTVGVPTRTGNTSEVVWTSPSCVPAETVATVTVTVTNSVNASVSKTFTLTANACPAPAVSAAGDHTLALRRDGTVWAWGFNGSGQLGNGTATDRATPVQVPGLTSVMAVAASEAHSLALRSDGTVWAWGDNGYGQLGDGTKAQRTTPVQVLGLAGVTALAAGGNGTTVAISAHSLALRSDGTVWAWGDNSAGQLGDGTTTERATPVQVLGLTSVTALAAGAFHSLALRDDGTVWAWGNNSSGQLGDGTTTARPTPVQVPGLTSVIAVAAGGGDDSLGMRGDHSLALKSDGTVWAWGYNLSRQFGDGMPATRTTPVQVSELTGGTALVAGDLHAVVLKSDGTVWAWGDNSSGQLGEGVTPVRAKPMQVSGLAAITALATGDGHSVAVGSDGGIWAWGDNRRGQLGIGITATREIPVQATGLASISALAAGDSHSLALRGNGSVWTWGSNAYGQLGDGTAIDRATAAQVPGLTDITALAAGNHHSLALRNDGTVWVWGSNDFGQLGDGTVTSRKTPVQVSGLSAMRAVEAGPAHSVAVHLNGTVWVWGNNDFGQLGDGTVTSRAMPVQVSGLTGVTAVAVGVYHSLALRNDGTLWAWGYNNVGQLGNGTSGIQSTPAQVPGLTGVIALAAGNGHSLALRTDGTVWGWGANSFGQLGDGTTTPRSTPTQVPGLTNVIALNAGAFYTVALRSERSVWEWGSKSAGQLGDGTVTQKTTPVQVSGLTDVTALAAGNAHALALRTDRTVWAWGGNQRGQIGDGTASIMPAPVNVSFP
>NC_014623.1|WP_081465983.1|310653_311985_+|IS4-family-transposase
MARLVLQRAVSAEWMDSLFEAHRKRQYTRELLFSTVVELMSVVAMGLRPSLHAAAKATEGGTSIAALYEKVNRMEPDLVRALVRGSAQRLEPVVQPLRTGEKPWAEGYRVRVMDGNHLPASEKRLKPLREFRGAALPGHSLVVYAPEQGLVVDVVPCEDAHAQERTLVAAVLEHAQQGDLWIADRNFSTTRIVFGLEDRHAAFIIREHGRTPSPTEVGKRKRVGRVETGVVFEQPVQVEDDGGRLLTLRRIELQLDEPTEEGEPLIRLLTNAPKEKLSAEKVACLYRKRWSIEGMFQSLESALHSEVRTLGHPRAALLAFGTAVVAYNILAVIQAAVEAAHPEAKAEGIELSPFFVATEVQATYGGRMIAVGDDVWTAFDEQSPLQLSRTLIRIAQHAQPKRLRKHPRGPKKKTKKGYVSGRTARQHVATARVLASGRIDSTS

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Crispr_ID: NC_014623_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014623_2

401430-401793

Orphan

Consensus_repeat	Method
AGGGCTGCCCGGACACGGACAAGGATGG	CRISPRCasFinder

4 spacers

The CRISPR arrays of NC_014623_2

>merge|NC_014623|2|401430-401793|CRISPRCasFinder
AGGGCTGCCCGGACACGGACAAGGATGGCATTCCGGACGCGGCGGATCAGTGCCCGTCGGCGGCGGGTCTGGCGGTGTTCAAGGGCTGCCCGGACACGGACAAGGATGGGCTGCGGGACTCGGAAGACCTGTGCCCCCTGGAGGCAGGTCCCGCGGACCGCCAGGGCTGCCCGCAGAAGGACTCGGACGGGGATGGGTTGCTGGACGAGCAGGATGCGTGCCCCAGCGTGGCGGGCTTGAAGGAACTGAAGGGCTGCCCGGCCAAGGACACGGACAACGACACGGTGTCCGACCACCTGGACAACTGCCCCAACGAGGCGGGCCCCGCCAGCAACCAGGGCTGCCCGGCCAAGCAGAAGCAGTT

>NC_014623|2|2|401430-401793|CRISPRCasFinder
AGGGCTGCCCGGACACGGACAAGGATGG	CATTCCGGACGCGGCGGATCAGTGCCCGTCGGCGGCGGGTCTGGCGGTGTTCA
AGGGCTGCCCGGACACGGACAAGGATGG	GCTGCGGGACTCGGAAGACCTGTGCCCCCTGGAGGCAGGTCCCGCGGACCGCC
AGGGCTGCCCGCAGAAGGACTCGGACGG	GGATGGGTTGCTGGACGAGCAGGATGCGTGCCCCAGCGTGGCGGGCTTGAAGGAACTGA
AGGGCTGCCCGGCCAAGGACACGGACAA	CGACACGGTGTCCGACCACCTGGACAACTGCCCCAACGAGGCGGGCCCCGCCAGCAACC
AGGGCTGCCCGGCCAAGCAGAAGCAGTT

Protein	Signature genes	Signature genes Name	Protein_function
NC_014623.1\|WP_013374090.1\|409960_410458_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|185628
NC_014623.1\|WP_002612309.1\|409392_409812_-\|hypothetical-protein	unknown	unknown	unknown
NC_014623.1\|WP_002612320.1\|395385_395907_+\|hypothetical-protein	unknown	unknown	unknown
NC_014623.1\|WP_013374092.1\|411097_411925_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366004
NC_014623.1\|WP_037583184.1\|393821_394544_-\|acyltransferase-family-protein	unknown	unknown	gnl\|CDD\|153249
NC_014623.1\|WP_002612334.1\|402190_406498_+\|adhesin	unknown	unknown	gnl\|CDD\|375438
NC_014623.1\|WP_013374084.1\|394752_395241_+\|hemerythrin-domain-containing-protein	unknown	unknown	gnl\|CDD\|376622
NC_014623.1\|WP_002612293.1\|411951_412500_-\|putative-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|377672
NC_014623.1\|WP_002612311.1\|391205_391850_-\|hypothetical-protein	unknown	unknown	unknown
NC_014623.1\|WP_002612328.1\|392938_393829_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NC_014623.1\|WP_013374082.1\|392003_392942_-\|proline-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|223580
NC_014623.1\|WP_013374093.1\|412644_413073_+\|hypothetical-protein	unknown	unknown	unknown
NC_014623.1\|WP_002612325.1\|406733_408200_+\|response-regulator	unknown	unknown	gnl\|CDD\|143636
NC_014623.1\|WP_002612331.1\|387569_391175_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_014623.1\|WP_002612335.1\|397026_397779_+\|hypothetical-protein	unknown	unknown	unknown
NC_014623.1\|WP_037583181.1\|408746_409334_+\|Fis-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225114
NC_014623.1\|WP_002612302.1\|410567_411101_+\|O-acetyl-ADP-ribose-deacetylase	unknown	unknown	gnl\|CDD\|394878
NC_014623.1\|WP_013374086.1\|398029_399928_+\|OmpA-family-protein	unknown	unknown	gnl\|CDD\|143586
NC_014623.1\|WP_013374085.1\|396085_396952_+\|tryptophan-2,3-dioxygenase	unknown	unknown	gnl\|CDD\|188272
NC_014623.1\|WP_013374088.1\|408204_408600_+\|type-II-secretion-system-protein-GspG	unknown	unknown	gnl\|CDD\|130771

Protein	Function_ID	Function_description	E-value
NC_014623.1\|WP_013374090.1\|409960_410458_-\|hypothetical-protein	gnl\|CDD\|185628	PTZ00449, PTZ00449, 104 kDa microneme/rhoptry antigen; Provisional.	1.96135e-05
NC_014623.1\|WP_013374092.1\|411097_411925_+\|hypothetical-protein	gnl\|CDD\|366004	pfam00291, PALP, Pyridoxal-phosphate dependent enzyme. Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.	0.00115389
NC_014623.1\|WP_037583184.1\|393821_394544_-\|acyltransferase-family-protein	gnl\|CDD\|153249	cd07987, LPLAT_MGAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.	3.74894e-44
NC_014623.1\|WP_002612334.1\|402190_406498_+\|adhesin	gnl\|CDD\|375438	pfam17936, Big_6, Bacterial Ig domain. This domain is found in a wide variety of extracellular bacterial proteins often in multiple tandem copies.	1.74795e-08
NC_014623.1\|WP_013374084.1\|394752_395241_+\|hemerythrin-domain-containing-protein	gnl\|CDD\|376622	pfam01814, Hemerythrin, Hemerythrin HHE cation binding domain. Iteration of the HHE family found it to be related to Hemerythrin. It also demonstrated that what has been described as a single domain in fact consists of two cation binding domains. Members of this family occur all across nature and are involved in a variety of processes. For instance, in Nereis diversicolor hemerythrin binds Cadmium so as to protect the organism from toxicity. However Hemerythrin is classically described as Oxygen-binding through two attached Fe2+ ions. And the bacterial NorA is a regulator of response to NO, which suggests yet another set-up for its metal ligands. In Staphylococcus aureus the iron-sulfur cluster repair protein ScdA has been noted to be important when the organism switches to living in environments with low oxygen concentrations; perhaps this protein acts as an oxygen store or scavenger.	0.000361295
NC_014623.1\|WP_002612293.1\|411951_412500_-\|putative-ABC-transporter-permease	gnl\|CDD\|377672	pfam06541, ABC_trans_CmpB, Putative ABC-transporter type IV. CmpB is a family of membrane proteins that are likely to be part of a two-component type IV ABC-transporter system. Families can transport multiple drugs including ethidium and fluoroquinolones. UniProtKB:Q83XH0 is a member of TCDB family 3.A.1.121.4.	1.68964e-12
NC_014623.1\|WP_002612328.1\|392938_393829_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	2.99014e-20
NC_014623.1\|WP_013374082.1\|392003_392942_-\|proline-dehydrogenase-family-protein	gnl\|CDD\|223580	COG0506, PutA, Proline dehydrogenase [Amino acid transport and metabolism].	1.31444e-46
NC_014623.1\|WP_002612325.1\|406733_408200_+\|response-regulator	gnl\|CDD\|143636	cd07302, CHD, cyclase homology domain. Catalytic domains of the mononucleotidyl cyclases (MNC's), also called cyclase homology domains (CHDs), are part of the class III nucleotidyl cyclases. This class includes eukaryotic and prokaryotic adenylate cyclases (AC's) and guanylate cyclases (GC's). They seem to share a common catalytic mechanism in their requirement for two magnesium ions to bind the polyphosphate moiety of the nucleotide.	2.37224e-68
NC_014623.1\|WP_002612331.1\|387569_391175_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	4.18504e-92
NC_014623.1\|WP_037583181.1\|408746_409334_+\|Fis-family-transcriptional-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	1.54534e-05
NC_014623.1\|WP_002612302.1\|410567_411101_+\|O-acetyl-ADP-ribose-deacetylase	gnl\|CDD\|394878	cd02908, Macro_OAADPr_deacetylase, macrodomain, O-acetyl-ADP-ribose (OAADPr) family. Macrodomains are found in a variety of proteins with diverse cellular functions, as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Macrodomains can recognize ADP-ribose (ADPr) in both its free and protein-linked forms, in related ligands, such as O-acyl-ADP-ribose (OAADPr), and even in ligands unrelated to ADPr. This family includes eukaryotic macrodomain proteins such as human MacroD1 and MacroD2, and bacterial proteins such as Escherichia coli YmdB; these have been shown to be O-acetyl-ADP-ribose (OAADPr) deacetylases that efficiently catalyze the hydrolysis of OAADPr to produce ADP-ribose and free acetate. OAADPr is a sirtuin reaction product generated from the NAD+-dependent protein deacetylation reactions and has been implicated as a signaling molecule. By acting on mono-ADP-ribosylated substrates, OAADPr deacteylases may reverse cellular ADP-ribosylation.	1.9072e-92
NC_014623.1\|WP_013374086.1\|398029_399928_+\|OmpA-family-protein	gnl\|CDD\|143586	cd07185, OmpA_C-like, Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA. OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.	2.56816e-41
NC_014623.1\|WP_013374085.1\|396085_396952_+\|tryptophan-2,3-dioxygenase	gnl\|CDD\|188272	TIGR03036, trp_2_3_diox, tryptophan 2,3-dioxygenase. Members of this family are tryptophan 2,3-dioxygenase, as confirmed by several experimental characterizations, and by conserved operon structure for many of the other members. This enzyme represents the first of a two-step degradation to L-kynurenine, and a three-step pathway (via kynurenine) to anthranilate plus alanine. [Energy metabolism, Amino acids and amines].	2.07498e-137
NC_014623.1\|WP_013374088.1\|408204_408600_+\|type-II-secretion-system-protein-GspG	gnl\|CDD\|130771	TIGR01710, Type_II_secretion_system_protein_G, type II secretion system protein G. This model represents GspG, protein G of the main terminal branch of the general secretion pathway, also called type II secretion. It transports folded proteins across the bacterial outer membrane and is widely distributed in Gram-negative pathogens. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis].	3.29924e-10

>NC_014623.1|WP_013374086.1|398029_399928_+|OmpA-family-protein
MNQPTSLPKRPAITPIRLSLLSALVLSTSALAQPAGLPEFEVERIEFNPSGAGSLVLGTGQVLPGDSFRLALIGHYENRPLTPSIPDASAENGRREVPLINHRTTAHLVGAYGLGGNVEVGLQVPVILSNERGLLENTPFGTPEGGVKLGTPIATFNLGILTQSEAIPVDLAAGVSLGLPLGSDQALARESGPRAIPRITVGRESDGFRTGFELGAALRPRVTIGTGESSEAYNTLRLGTSVATVGEGLRYEGNLLLNIPFGTESLSAEALVGVRGPRSSGIEVFALGGMGFGGTLGTPDFRVMLGAAYGGMPARCVAGGKHTPAQCPDLDDDNDGVKNSDDACPTEGGKVDTKGCPLKDEDKDGVEDVADKCPQTPGAASAQGCPDQDGDGIQDSEDKCPAAAGNAAGQGCPDKDGDGIDDASDRCPAEAGPAERQGCPIKDADNDGVLDEQDSCPNEAGLPELKGCPAKDADNDTLADHLDNCPNEAGPVDNQGCPAKQKQLVAIRQDRIEIKEAVYFDSNASTIQARSNGLLDQMAKLLNEHPEIVSVLIEGHTDDRGAADYNRTLSKQRADTVRDYLVKKGVAAERLETQGYGPDRPVQPNTTAAGRTANRRVDFLTRYANTNPPAQP
>NC_014623.1|WP_002612335.1|397026_397779_+|hypothetical-protein
MVPLVLALAVSAAPPPAVDAWARQVCPPSKKEARSNAEFKVQQAERVACLERAMNQAVDKVLRPLQKKEPGTFRQWVALQSDYHQWASEACAAVEEALWINTRTGEHSMGTAYGSTERECLQGQYAWRGFFAETWSRGDWKTLASVLERYAQGLPRRRDALAQYRQRAAEAAGRAPAKVERMDSPSRKLTQDEWARYSSRLNRVANAPPRLAERQCALLPKAKPSCPELLLPAFMEHLDFHEALGVSEER
>NC_014623.1|WP_013374085.1|396085_396952_+|tryptophan-2,3-dioxygenase
MNKREMEPGIVTELAGHTTYGEYLQLDRLLAAQVPRSQPPHHDEMLFIVQHQTSELWMKLLIHELTACIRYVQADQLEPSFKIFARVGQIQRMLFEQWSVLETLTPNEYLAFRDALGHASGFQSFQYHAVEMLLGMKDAKTLNPFRHVPAQHALLERLLESPGLYDEFLRHLARMGHPVPHDRAQRDWSQPYEKSPQVMEVFRRIYENTEKYWDAYEMCEKLVDTEERFQLWRYRHMMTVMRIIGFKQGTGGSSGVNFLRKALDIRFFPELWDVRTELSPLPSRRPPV
>NC_014623.1|WP_002612320.1|395385_395907_+|hypothetical-protein
MSVDKAFREMIRNEIEVQLKPLRAVVARLEAGTADLESLRSVVERLAPVAQAISPLFGTQAPKTGKRPPGRPPRAAAPAAAASAPASTGKRRGRKPSEDGARVCAIRGCGSPSRTKGYCAAHYQKLRMLTKTNRRPSAWVDYAPPNSVEDVKLPRGRAAAKALAEAAQSGGAS
>NC_014623.1|WP_013374084.1|394752_395241_+|hemerythrin-domain-containing-protein
MGPFDILSEKHRELEEHLEALLSEEGGAEAAERAWGLASLIRQHTRLEERHLQPLILRVEGRSRAREALEDHLALCELAEELEEFAPGGPEWQARLTALEDLLVAHAQEQEAALFPRIATCLNEREGEELLRVLESSQEDLGGRFGSSTEGQRLLDAPRWGP
>NC_014623.1|WP_037583184.1|393821_394544_-|acyltransferase-family-protein
MESLSATTRRAFFRLAEAGATLSAMYHRAQLLGAEHLPRNGPVLLVGNHGVWGYETPAFFHLLHQASGRYPLGLAERGFFRIPLVRTVLPWLGGLEGTPANALAALREGQLVVCYPGGAREVFKRSQGRYMLRWEQALGFVRLAARAGVPIVPFAGFGVDDTFFYPPGEERLCLRLSARDKYRVPLVMGLGPIPLPVRLTFAMGEPHEPPPENASETRLKAFRDRVAASVRRLLVRACHA
>NC_014623.1|WP_002612328.1|392938_393829_-|alpha/beta-hydrolase
MLEAPSPQAPALVPALEDIQHGYALPLEERRVRGAPIRLFTFPNGTEEASRTVVCLPGLGASGRSFAPLAPLAPHHRLLLWTPTLRTPLTHAPLQWNVEALAHPEARLPPRFSLLGSSFGSLVSLAFALKHPERVRALILVSPVPSVHRVRRWALSLSTLVRIPKPFAYLFAPTVARVLGGRYLPPEGRAEIVREARRLSPLEMLRRLRDILDADYLESLEHLRVPTLIIHGARDHVVPLSDACDVARRIPGARLEVLREASHLPYMSHPQAFNAFVDDFLQDHLSDPPAATPSAP
>NC_014623.1|WP_013374082.1|392003_392942_-|proline-dehydrogenase-family-protein
MTPTPTDLSRSALLFLSRQEGLKSAATRLAPLREMASRFIAGEKLEDAVEAVKALNAQGLMASFDHLNEAVRTPEETRDEVREYRRLLARIDAQGVRANVSLKLTQCGLMFDPALALANARTVVAEATARQSFVRVDMEQSEVTQATLDIVGALHAEFGEARVGAVLQSYLRRTEADAKALCARRVRIRLCKGAYLEGPRVAFPDKRDVDANFIRVMRVLLDSGVYHGIATHDERMVDATVEYAARQHLPKGAFEFQMLYGIRRDLQLRLAGEGFPVRIYVPYGRSWYPYFMRRLAERPANLWFVMKNLLKG
>NC_014623.1|WP_002612311.1|391205_391850_-|hypothetical-protein
MDADVWRQLLRTDPHAYRARVLFFARTDWHALREHRVSLSLEEFLLHLEALFQPDGLGPGDRFEMSLWWGEEQPHYTLHVRGQDGMRRPESVGNVGATHRRAVARWVKDTTRRRGMHPWQVHVGAPPPYRPPQELLDACLAEFPDARVTSLTVQRFEGIQAPGFSVEPGARIEASLEALDGGIIQVFLGEWTEEDSLRLEEWAQVARTGYAQGP
>NC_014623.1|WP_002612331.1|387569_391175_-|serine/threonine-protein-kinase
MLEEHEAELRIALSEGLISREEAEGLREEARHRRLSPLAVLRERGVLSEKSLASLRGLEEEPTVTRARPGGADTLGPALTLQDRHKVDPRFPVPNWERYQGVRFLGQGGMGQVFLAYDPRLRRNVALKFVRGDDTELVQRLLSEARAQARVDHERVCQVFEVGEVEGRPFIAMQYVNGQPLSQLTHELTVEQKAMVLRDAAEGVHAAHRAGLIHRDLKPSNILVERTEDGRLKPFVMDFGLAREWSESGNTATGAVLGTPHFMSPEQARGEVARLDRRADVYSLGATLYHLITGRHAIPGTNGLEVLTNIPTVEPSSPRKLDPDVPRDLEAIVLKCLEKDRSARYDSARALAEDLDRFLAGEPVLARPMGLGYRLRKKALKHRVAVSVSAVALLAVALALGWAFYTQRQASRREYLARRFTEQVEHIEALARYSGLSPLHDTRADLQELRQHIATLESEVARAGGLAAAPGRYALGRGALALGDEVSARQHLEAAWRSGYREPRVAYALALVMGHLYQDGLLEAERLRDASVREARRQEVERQYRDPALAYLRQSEGADVPSTEYVAALLSFYEGRFDDALARLDAMGNRLPWFYEAPLLRGDILQARAARHWNQGEGEEAKKDLEEGRRAYAAAADIGRSVPSVHQAVAKLEYTAMLMALYGQGDVHAPFTRGMEGITRALQALPKAPASLLQEARLYRRFAEAQIIRGEGSREPLDRALAAAREVIQQQPSTWDAHQEEGLLLYFSARILKDRGMDPREQLRAAQQALEKIPQEKRDVEFYNALGLIFFAWAGHDDDTGANSQEHWQNAIDSFQSATRLSPGYLGAWINLGMACYRHADGPMVGPTAQALREQRLQQAWEALQRAMELNPQHWVAYFYGGNIHNLWGAMHRCDAGGSRYLESARELFRKGLAINSQAPNLHNGLGFTLFNLAQLNWEQGGNAYSLLDEAQASYDEAIQLAPRQVYGYLNRGSAFLLRATFQRDQGQDSSASLQAALRSFEQAIHLSQDDPDAQAGLGESLVWLADAELKRGRAPTPLLHRAEKALREALKINPQHPRAWLYLGQSHSIQARWQSQGAPVTQASFDEATRSFEKALALAKDSSDVHLAFGALMHDWATFETRAGRTPTVPLERGLTLVEEALSTCSEWPRALLLRAQLRRMRAVTETANAAEQQAWMAQSRNDLSLALKKNPNLAPGWKD
>NC_014623.1|WP_002612334.1|402190_406498_+|adhesin
MNSAFLKNSFRTALLALLACALPALAAPDNVLLGTGRDGAFTASSLNQIINRYVQVTTPRLPGDTSLVVQDATGYAAGDLVMVIQMTGIVPEPGSGSSTPIDLSNDPVGRWEFARLASVSGTTLTLTAPLIHSYAANVTQAIRVPEYTAVTIGAGRSLTAAAWNGSTGGVLAFLATGTVTNSGGINVSGKGFRGGKPVVDTSLATGCFGLDEAPAQGAQKGEGIAITRYGPLQTGRGRVANGGGGGVCFKSGGGGGGNAGAGGQGGNSFLDEFGTPDSGNRSVGGEGGLLLTLSLADRLMMGGGGGAGHSVDGTSRAGGEGGGILFIRAAQFAGTGVVTANGLTSTPSSGTDAAGGGGAGGSIYLRVTATALPNPPVCGVVQAVGGRGGDADLEVGPGGGGGGGRIYFQRFATGNACYPTATAAIGATAGGQPNPDVGTSYGAQAGANGSYLRIDTAPYPSAVPPTPVVETPANGSVTNNTTPTYTGTLPTPFPAGTQVALFVDNVQVALVTPNAAGNWSATPGTALGQGPHSVYAVAVIPDQVVYGNSSNTNTFTVDITPPAAPVVTTPANGSTTNDNTPTYSGTAEPGSAVNIIVDGTSVGTATANASGNWSFTPTTPLADGPHTVRATATDVAGNTSPSSSTNNFTVDATAPVAPVVTTPANGSITNDNTPTYSGTAEPGSTVNIIVDGTSVGTATANASGNWSFTPTTPLADGPHTVRATATDAAGNTSPSSSTNNFTVDATAPVAPVVATPANGSTTNDNTPTYSGTAEPGSTVNVIVDGTSVGTATANASGNWTLTPTAPLAEGPHTVNATATDAAGNTSPVSSTNTFTVDTVAPAAPVVTTPANGSLINDSTPTYSGTGEPGSTINVIVDGTSVGTTTVDGSGNWSFTPTTPLAEGPHTVSATATDAAGNTSPSSNTNNFTVDTVAPAAPVVVTPANGSTTNDNTPTYSGTAEPGSTVNVIVDGTSVGTATANASGNWTLTPGAGLSSGPHTVNATATDAAGNTSPVSNTNTFTVDADPPEAPVVVTPANNSVTNDNTPIFSGTAEPGTTVAIYLGAVELVANVPVDASGNWTYTPTTPLADGTYDVSAVATDGVGNASGSSNVNRFTVDATGPAAPVITSPVDGSSTGDSTPTITGTAEPGSTVTVVIDGTVVGTAPVDASGNWTYTPTTPLAEGPHTVTATATDAAGNTGPTSEPVDFIIDESLPGTPEITGPANNSTTNDSTPVISGTAEPGSTVTVVIDGTVVGTVPVDASGNWSYTPTTPLADGPHTVTVTATDNTGNVSAPSTPVTFTVDTIAPDTVIDSGPPPSTESSDATFAFSSDEEGVTFECSLDGGDFVPCSNPVTFPGLSAGGHVLEVRARDLAGNVDETPAEWTWTVTSPETPSGGNLDFLGDGIGCASAGGSPSTLAVMGLAVLSALFFRRRRA
>NC_014623.1|WP_002612325.1|406733_408200_+|response-regulator
MSSSSPLFGDLLLKLGIVTPSQVQEALALQPRTGQRVGEALISLGYVTRAQLHDALSEALGLNHDKGPAHPPLGELLVGLKYITLGQLEEALAFQRKDGRKLGEILVEMGHCTYRQIYEALSLQGRITGRQEAPRQVLQGHHRVMVVDDSPLACDFVKEGLEALGLGYEVMCFQDPYEALEQVGKVQPAIVLSDLDMPGIDGLELCWRLKESPSRQVPVIILTANDSEAERVKGLRAGADDYVNKSASMAELSARIESVMRRTSETERMRKLFARYTSDAVVEEILKSPDTVVLTGEKREVTVLFADIRNFTGLAESLPPEQVVGVLNQVLGRLSDAVLTCGGTLDKFLGDGLMAVWGAPVHRTDDALRALQAAKMMMTAMVELRQAAQAEWAANERLGRPLVLELGIGINSGLAVAGNIGGSMRTEYTCIGDAVNVAARLCALAGPGEILAGERTRELVSHREMPFEDLPPVRLKGKQQPVPLYRVL
>NC_014623.1|WP_013374088.1|408204_408600_+|type-II-secretion-system-protein-GspG
MTGTSQQVVSSPRPARLLLVVALVLCAVAVPTTLALRGEQHPSYARVHADFAVLNAALEKYRAAQGTLPEDGALDFLVPDYLPELPVDPWGRPYVYLYNGQQVFLATFGEDGLRGGSGVEQDHTIHDGHTH
>NC_014623.1|WP_037583181.1|408746_409334_+|Fis-family-transcriptional-regulator
MIPRGYGEEELVSNRASLLLYGGTEEERRLWAQEAAYHFEHEGAMVEVRQAADLAPALQRPKGVVFIPDVSKLSREAQGTILRCLQTQEERPKVVVAILGSAEAALERGVLRDDLHYRLHQAQVNLAQPGLRETLRERWARLAELRAVKEAKAREEAERERQAAMTRLPGTVTRLTPQQRKVQGSKPSSRKASRR
>NC_014623.1|WP_002612309.1|409392_409812_-|hypothetical-protein
MSESHSQTGAETLTPILFVPERHFDQILRWNQARKEVLTQDILPQTGFILPGKAAGFLYRTDSSVAWIENLVAAPELSREERSVAIDAIVKAVSDEARRLGFKMLLGYTVLDVVVKRAQRLGFAHVEGDFKLVALQLNP
>NC_014623.1|WP_013374090.1|409960_410458_-|hypothetical-protein
MATLRRGLVDKVKKAAARVSTRSAEVAAKAGTRGARAIVETTVAAVKTVDSIQQKLGRKPSKAAAPKQAAAPKPPAAPKAPTAPKPPTQRVISTETASAEPAIPKQPRRAATASPIEVPPVAGRDAGRKTMPAASAKRTKAPKPGKAPKPVFKAKRGQKHIHTGR
>NC_014623.1|WP_002612302.1|410567_411101_+|O-acetyl-ADP-ribose-deacetylase
MRRVLWLGDITTVAADAIVNAANESLLGGGGVDGAIHRAAGAELLEECRTLGGCPTGEARITRGYRLPARHVIHTVGPRWHGGGQGEAALLARCYQSVFARMEEHGLRTVAFPSISTGVYGYPIEQASRIALREIHAALERRPALEKVTVVLFSPGDLQVYQRALAELPGAQEGTPG
>NC_014623.1|WP_013374092.1|411097_411925_+|hypothetical-protein
MSAAPERRTRGRTSPSRLRALDAYLLHCERPLLERQDGPWGEAAFLDVGFGEHPWTTLESARGFRELNPALRVIGVEADPARAAAAASHEGERTHFRQGGFGWAREAGQPVRLVRAMNILRQYRPEEAAAAHGELGQALLPGGLLVEGSTDGPGGITVAYLLRREAGGLRREALLFHTDFHQGFAPLLFRDWLPVDWRRRMAPGSALHAFFAAWTAAWIEARAHGANTPAESFHQGARRLSQAWPGVSEEPWLWENGYLRWQPPAGVPRPGEPIA
>NC_014623.1|WP_002612293.1|411951_412500_-|putative-ABC-transporter-permease
MSGGRSERQRPLGSEGQPLGTFARFVVYGLMGWCIECLFTSLVDLATGAGDLRLRGYSYLWMHPIWGVGLLLGEQLVGVMKRAGLSRLLRATLGMVLCFAVEYLTGAGLVAVLGLCPWDYSAAWASVNGLIRLDYAPYWFMCALMCEFIFALVGRVQLGGGAAWAHSPHSPTEPPASLPASL
>NC_014623.1|WP_013374093.1|412644_413073_+|hypothetical-protein
MSQDTPRPKRGLKRPIEVVRAELLKDADTKRIAKSVGMELEAYVELVLEYAQDKDKEPMIAVVSDEELHAKGFKTPTNEDVAKLLTKAAKGELGVNEEFEKSEFSAARAPKGPSLTGESGSTAGLKTDPSLLDQVKKNGAKS

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Crispr_ID: NC_014623_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014623_3

615520-615624

Orphan

Consensus_repeat	Method
GGCACGGACCCGGATGGGGGCACGGAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014623_3

>merge|NC_014623|3|615520-615624|CRISPRCasFinder
GATGGCGGCACGGATGGGGGCACGGACCCGGATGGGGGCACGGACGGAGGGACGGACGGAGGACCGGATAGTGGCACCGATGGGGGGCCGGACGGAGGCACGGAC

>NC_014623|3|3|615520-615624|CRISPRCasFinder
GATGGCGGCACGGATGGGGGCACGGAC	CCGGATGGGGGCACGGACGGAGGGACGGACGGAGGACCGGATAGTGGCACC
GATGGGGGGCCGGACGGAGGCACGGAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_014623.1\|WP_002616781.1\|603271_605617_+\|response-regulator	unknown	unknown	gnl\|CDD\|236901
NC_014623.1\|WP_013374189.1\|625016_625493_+\|hypothetical-protein	unknown	unknown	unknown
NC_014623.1\|WP_002617845.1\|608553_609288_-\|zinc-dependent-peptidase	unknown	unknown	gnl\|CDD\|377621
NC_014623.1\|WP_013374188.1\|620335_623077_-\|EVE-domain-containing-protein	unknown	unknown	gnl\|CDD\|183088
NC_014623.1\|WP_013374182.1\|606743_607922_+\|DUF1986-domain-containing-protein	unknown	unknown	gnl\|CDD\|214473
NC_014623.1\|WP_013374191.1\|627041_628697_-\|DUF2339-domain-containing-protein	unknown	unknown	gnl\|CDD\|378390
NC_014623.1\|WP_013374181.1\|605641_606379_-\|hypothetical-protein	unknown	unknown	unknown
NC_014623.1\|WP_002613002.1\|630037_631429_+\|aminopeptidase-P-family-protein	unknown	unknown	gnl\|CDD\|376349
NC_014623.1\|WP_002617841.1\|623245_624760_-\|DUF4241-domain-containing-protein	unknown	unknown	gnl\|CDD\|379427
NC_014623.1\|WP_002617844.1\|619076_620339_-\|restriction-endonuclease	unknown	unknown	gnl\|CDD\|370821
NC_014623.1\|WP_002616797.1\|602651_603167_+\|hypothetical-protein	unknown	unknown	unknown
NC_014623.1\|WP_037584141.1\|609326_609620_+\|hypothetical-protein	unknown	unknown	unknown
NC_014623.1\|WP_002616773.1\|600106_601156_+\|response-regulator	unknown	unknown	gnl\|CDD\|234828
NC_014623.1\|WP_002617847.1\|615913_617647_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|366721
NC_014623.1\|WP_002612987.1\|628884_629991_+\|kelch-repeat-containing-protein	unknown	unknown	gnl\|CDD\|276965
NC_014623.1\|WP_013374183.1\|608047_608536_+\|YbaY-family-lipoprotein	unknown	unknown	gnl\|CDD\|378225
NC_014623.1\|WP_013374190.1\|625549_627019_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NC_014623.1\|WP_081465882.1\|611656_614125_-\|PAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|223715
NC_014623.1\|WP_002616790.1\|601152_602250_+\|response-regulator	unknown	unknown	gnl\|CDD\|223816
NC_014623.1\|WP_013374187.1\|617703_619005_-\|type-II-toxin-antitoxin-system-HipA-family-toxin-YjjJ	unknown	unknown	gnl\|CDD\|236623

Protein	Function_ID	Function_description	E-value
NC_014623.1\|WP_002616781.1\|603271_605617_+\|response-regulator	gnl\|CDD\|236901	PRK11360, PRK11360, two-component system sensor histidine kinase AtoS.	4.04288e-60
NC_014623.1\|WP_002617845.1\|608553_609288_-\|zinc-dependent-peptidase	gnl\|CDD\|377621	pfam06167, Peptidase_M90, Glucose-regulated metallo-peptidase M90. MtfA (earlier known as YeeI) is a transcription factor A that binds Mlc (make large colonies), itself a repressor of glucose and hence a protein important in regulation of the phosphoenolpyruvate:glucose-phosphotransferase (ptsG) system, the major glucose transporter in E.coli. Mlc is a repressor of ptsG, and MtfA is found to bind and inactivate Mlc with high affinity. The membrane-bound protein EIICBGlc encoded by the ptsG gene is the major glucose transporter in Escherichia coli. MtfA is found to be a glucose-regulated peptidase, whose activity is regulated by binding to Mlc available in the cytoplasm, which in turn has been released from EIICBGlc during times when no glucose is taken up. A physiologically relevant target for this peptidase is not yet known.	3.22374e-103
NC_014623.1\|WP_013374188.1\|620335_623077_-\|EVE-domain-containing-protein	gnl\|CDD\|183088	PRK11331, PRK11331, 5-methylcytosine-specific restriction enzyme subunit McrB; Provisional.	5.71759e-47
NC_014623.1\|WP_013374182.1\|606743_607922_+\|DUF1986-domain-containing-protein	gnl\|CDD\|214473	smart00020, Tryp_SPc, Trypsin-like serine protease. Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.	3.63613e-91
NC_014623.1\|WP_013374191.1\|627041_628697_-\|DUF2339-domain-containing-protein	gnl\|CDD\|378390	pfam10101, DUF2339, Predicted membrane protein (DUF2339). This domain, found in various hypothetical bacterial proteins, has no known function.	5.90579e-08
NC_014623.1\|WP_002613002.1\|630037_631429_+\|aminopeptidase-P-family-protein	gnl\|CDD\|376349	pfam00557, Peptidase_M24, Metallopeptidase family M24. This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.	1.43178e-13
NC_014623.1\|WP_002617841.1\|623245_624760_-\|DUF4241-domain-containing-protein	gnl\|CDD\|379427	pfam14025, DUF4241, Protein of unknown function (DUF4241). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 205 and 315 amino acids in length. There is a conserved GDG sequence motif at the C-terminus.	1.20364e-36
NC_014623.1\|WP_002617844.1\|619076_620339_-\|restriction-endonuclease	gnl\|CDD\|370821	pfam10117, McrBC, McrBC 5-methylcytosine restriction system component. Members of this family of bacterial proteins modify the specificity of mcrB restriction by expanding the range of modified sequences restricted.	8.6096e-35
NC_014623.1\|WP_013374183.1\|608047_608536_+\|YbaY-family-lipoprotein	gnl\|CDD\|378225	pfam09619, YscW, Type III secretion system lipoprotein chaperone (YscW). This entry is encoded within type III secretion operons. The protein has been characterized as a chaperone for the outer membrane pore component YscC. YscW is a lipoprotein which is itself localized to the outer membrane and, it is believed, facilitates the oligomerization and localization of YscC.	5.74635e-21
NC_014623.1\|WP_002616773.1\|600106_601156_+\|response-regulator	gnl\|CDD\|234828	PRK00742, PRK00742, chemotaxis-specific protein-glutamate methyltransferase CheB.	1.97995e-102
NC_014623.1\|WP_002617847.1\|615913_617647_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|366721	pfam01593, Amino_oxidase, Flavin containing amine oxidoreductase. This family consists of various amine oxidases, including maze polyamine oxidase (PAO) and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.	1.22659e-46
NC_014623.1\|WP_002612987.1\|628884_629991_+\|kelch-repeat-containing-protein	gnl\|CDD\|276965	sd00038, Kelch, Kelch repeat. Kelch repeats are 44 to 56 amino acids in length and form a four-stranded beta-sheet corresponding to a single blade of five to seven bladed beta propellers. The Kelch superfamily is a large evolutionary conserved protein family whose members are present throughout the cell and extracellularly, and have diverse activities. Kelch repeats are often in combination with other domains, like BTB and BACK or F-box domains.	3.09742e-38
NC_014623.1\|WP_013374190.1\|625549_627019_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	9.64541e-66
NC_014623.1\|WP_081465882.1\|611656_614125_-\|PAS-domain-containing-protein	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	2.71789e-48
NC_014623.1\|WP_002616790.1\|601152_602250_+\|response-regulator	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	3.49503e-23
NC_014623.1\|WP_013374187.1\|617703_619005_-\|type-II-toxin-antitoxin-system-HipA-family-toxin-YjjJ	gnl\|CDD\|236623	PRK09775, PRK09775, type II toxin-antitoxin system HipA family toxin YjjJ.	2.44472e-157

>NC_014623.1|WP_081465882.1|611656_614125_-|PAS-domain-containing-protein
MDNNKMPAAAPPHLPLGAFIRAQHAQILKDWEQSVRQLPHAQRLSRPRLLDHLPDLLERIANVVETVHTGGAASLEDMPEIHALDRLDSGYDLDEVAAEYALLRTCILHFYGDSVKSGGTESMALAMREMVSFNRTFDEAVAAAVSRYAQARERTLVALDRISEAALGTENLDTFLPKLLRVILETTEAVDSVTLLLREDDTLKVRSSAGLDEEAMSGFSVRVGEGFAGQIAAQQRPLEVRSAATDPLVNSAAFRTRGTRALYGVPLLYGGEVIGVAHMGSRTAFEFSNEDKLLFRAMVSRATGLLVQAWLADSEQAARAEAEAQKQLLKLVIEQSGEAIIMADAQGAVRIVNAEAKRQQCCGLKQVGPSEWLIEGPLLTEDERPLKEEDFFIRRALQGELVTDARWKSRRKDGVARTFSGTAAPLRRPDGVLAGAVLTARDETERLHREQERTETLALLDLLLAAIPMDMAFLDRELRYVRVNEALARSNGLPAEAHLGKSVAEVVPEYASRFEPLLRRVLETGEALRGFEFSLAPANNPSGPVQHWVADYFPVRTRTGEVLGIGCIIVNITGRKQQEERLRQTAEFRERFMGVVSHDLRNPLNAILLSANVLLRTDGVHANHAKVARRIVASGERMVRMIGELLDFTRGRLGGGIPVHLHPCHLRQLCRHVLEELEISHPGRELRLNAQGHFPGMWDPDRLAQLLDNLGKNALDYSPAGTPVDFTLLDCGDTLRIEVHNEGPPIPPALMPVIFEPFRRAVAGDAHPTSGLGLGLFIVQQIAQAHGGTVSVNSQEGQGTTFTVQLPRHPPVGMPRQPGHLY
>NC_014623.1|WP_037584141.1|609326_609620_+|hypothetical-protein
MRSNASLISSETIGLLDAHVSYGSILTEHLRNPVFVSPEPNPGRFLVNAADEACGHEKEILIRLALHVHGEQLHIVRGQRCEHALPGAAIATALRAL
>NC_014623.1|WP_002617845.1|608553_609288_-|zinc-dependent-peptidase
MSGLFRTLRRRRLLRRPFPAEWLGYLERRAPFLQKMAPEPRQRLLDLLKVFAWEKEFIGAGGFTITDEVRAVISATAARLVLYLDLSYYDRLREVIVYPDAFRIPDRTGVVLGEAKNWGTVILSWQSVLAGLSDPNDGHATATHEFAHVLDRQDGAFDGTPHLRRYSHYGAWAEVMGEHFQKLRQGQRAERQVMDDYGSVNEAEFFAVATESFFEKPWQMKEKTPDLYEELKRFYGWDPASTPP
>NC_014623.1|WP_013374183.1|608047_608536_+|YbaY-family-lipoprotein
MTQAKSVLLGCLAALALSACASKAGATRKEAPAPAASSSPAAEAEAPAAPVPAPPLQVTGKVLYRERIALTPEAVVKVEVVETGSEKAEGGVIAEQSFAHPGQVPIPFTVDVAPERIRPDGSYFLRARILDGGRVYSSTEPIPVLTQGNKSSDVQVRVRLGS
>NC_014623.1|WP_013374182.1|606743_607922_+|DUF1986-domain-containing-protein
MSNPVTVSAASNPLTRRKSWALIASMGAALAAGCGPEAAPETQATLGEASQEIVGGTNAAITDFPWQISFQSSSGSHFCGGSIIDANWILTAQHCVYEAANSPSHPSTVRVGAGSATRTGQVQIKQITDIIPYPGYSDATLGKDVALLRLSSPLTFNTSVKAIPLATAADVSAGRTDPGVVSTVTGWGTTSSGSSSLPTTLQKVDVPVVSNATASANYGMTITADQIAAGYAAGGKDSCQGDSGGPLVVNGASGKILAGVVSWGEGCALPNYPGLYARVSSFQPWINGIITKTPSSLLSQTGASAGSKAWKHYTITVPAGVSALTVAASGGSGDADLYVHTSTPTTSAYTCRPYASGNTEYCSIGSPRAGTWYVSLYGYTAASGVTLKATAY
>NC_014623.1|WP_013374181.1|605641_606379_-|hypothetical-protein
MSHPPKPPPEETPSPEAATASAPVEDAEQLTADQARDYLLSVLDYGQEEIDAKAGIIEELVDLVLPEMKVVAQPIRPPEEDPKEAEALEQRFNGVAVRERDAAWIKQPGLRLDSTTRPLVPRWSAPDKVGGVLRRELFLLTDGRLVTVETVTPWETDGGRHAARDILVGAREVTPAEVLRTFDFVATLKSLLRGLFDGAAVLMERNERPADLVERSGRFFTIIAQVAVGMKESADRLRRAGDSPA
>NC_014623.1|WP_002616781.1|603271_605617_+|response-regulator
MEGAFQASGLPVEGQVTSVGTLEELPAALSAGLVVLGDEGGVVEEAVARCRELHSRRFIPRTHLVVLTARSEEEQEALIRAGADECMPMQGGGWRRRVASFLRRLEAGGVGDATPRAPVSQRIPPESALRALLASTTSDLGHDFFRTLVTHLATSFRVTCALVGELQPERDSLRTLAFWLNGRFEDNVTYRLQGTPCHNAVLSSLCHYPDDVATRFPEDAMLLDLGMRGYLGAALKSSRGDAIGVLAILHGEPLDMGALDRALLEALAARAGAELERIRAQEALERARDFLRNTLDAVPDPLFVADRAHRFVAVNRAFCGFMRRSAEQLLGSSYHDFLPAHEADLGWRLDEQAFTSGQPIEREETLTGLNGATRTLVTKRATFTETPGQPFLVVTIRDITDHRRLETQLRLADRMVSVGTMAAGVAHEINNPLAYVCSNLAFLGDLLARGPVPAESLPELREVVAETEEGIGRVRAIVQDLKAFARSDEERFGPVDVHQVLEGALRLVRNELAYRARLVRALEGVPTVRGNEGRLGQVMVNLLVNAVQAFSKNDMDENRIRLATRCDGPDWVVVEVEDNGPGMAQEVLERIFDPFFTTKPVGVGTGLGLAICHSIVHSMGGQIEVRSRLGHGSVFRVVLPVYRGEDAVLPVLKARVEQEVPRRRLLLIDDEPAVGTSVRRLLQGVHEVHAVQDAREALSLLSSGEQYDAILCDVVMPGMSGVDFLRELEQREPLMARRTGLMSGGTFSTQAREFVAARSSDLLEKPFEPERLRTFVERLLA
>NC_014623.1|WP_002616797.1|602651_603167_+|hypothetical-protein
MPYIALEWDHRIGKPMIRYVVVQCAGLSVKCGGPQALAPRRDIAYFVNEETAAQDAQAFADFKNAQAAGRDPFLNPEKDLNQEPRRHLAFGWDHLLHSPLIQWAVLEWGGEGGPPMPRTDVAYFLDPATAERDAKAFSWMRDDWKESADTQGRVGWERRAYTPETPSSAAS
>NC_014623.1|WP_002616790.1|601152_602250_+|response-regulator
MKPRVLIVDDSATVRADLRVVLGAAGFSTLLCGGIGGARKALSEERFDLVILDVLLQDGDGVDLLMEMRAHERTSQVPVLLLSSESAVGARLRGLSEGASDYVGKPYDSAFVVKRARELIQSRPPPPSKAIEPEPPLVAAARRRRLLVVDDSPTFLQAVVEELRQDGHDLIPARSAEEALPLLEAQPVDCVLMDLMLPGMDGISATRIIRSRPALASVPVLMFTSRFESQKMAEALNAGVDAFCPKASDLGLLRAQVRNLLRRQSPEAESAAPAKPSAAPKPPEGSALLERVVARSGLSPVIASSTISRACRRASVEPQQLSVVSLTQALPFIREALRVFLTEHETRQRMADIEELTRDGHLAMV
>NC_014623.1|WP_002616773.1|600106_601156_+|response-regulator
MTTRALRILIAEDSPTVRRRLVDAFSADAGCMVAAETADGDRAFELCQRLRPDVVTLDLALPTMNGVELTRRIMAHCPTPIVVFSSPENRNRGLHLLDALSAGAVDAMEKPMRATGEDWMVELLARVKLAARVPSITHPLGRLKLEPEPLRDLPARAVVIGASTGGPAAMKDILQRLPRDFPLPILLVMHLSEQFEVSMVEWLGKYSPLPVRQAVDGEMLPSTCRPAVVLARANRHLELSEGLLRLTNGPERHSCRPSVDVLFESAARELGGRAIGCLLTGMGRDGAEGMDALKRSGAVTLAQDEASSVVFGMPREAIRLGAARHVVGLQDIPGWLAALARRRPERGHA
>NC_014623.1|WP_002617847.1|615913_617647_+|FAD-dependent-oxidoreductase
MDGSDTFPDGESRRMARTHLMSLVLSALRTARRAQAAGVPVVEYAAMQQERSRFNRRSFLHLTAGAAGAATLAACGDEGGASPEDVVIVGGGTAGLHCAYRLRRLGIDAQVYEASKRVGGRMFTARNVFPEGQTAELGGELIDTGHLTLHDLSEELGIELLDFEKEDASLSRLVAMFDGNRLTEEQILQGFAPIAERIDAALATLEDPEEYITYRTPNGAQALDQLSLRAWMDVADIPASDPVRKLIELAYVGEFGLETDVCNSLNLLTFISTDTTRFELFGESDERYRSKGGNELFPQRLAERLGPGQIHLEHRLRAVKSLSDGRYQLTFDAAGRTQEVKADHVVLALPFSVLRNVDLQVELPAVKRKAIQELGYGTNAKLMVGFSARPWRDGYMSDGSTYSDVGYMQTWETSRQQPGTSGIITNFTGGAKGLAVGEGTTDSQVSAFLDGFDQVFPGVKEVANGSAARMHWPSHEFTRGSYSAYKVGQFTTISGAEIERVGNLHFCGEHTSLDAQGFMEGAALTGAMAAAEVAGDLGLQVEEALGPGARIMARAQSARVHGRWLDAARRASRRRAG
>NC_014623.1|WP_013374187.1|617703_619005_-|type-II-toxin-antitoxin-system-HipA-family-toxin-YjjJ
MTSVNLLLEALDRLPTARASDLSKQLEVSQPTVSRLITAAGERVCRMGAGRQTRYARTRTLLPLGTRVPVYRIDEEGRIHPHGVLHFLTHRRHWLAREEGLSELFDGFPPFAEDMAPQGYIGRSFAARHLELKLPPRLQDWTEDHALLALAQRGEDCVGNLIIGDESLNRFLAEPPSPSSRSDYPQIAQAALSRQPGSSAGGEQPKFATCAEDRHVIVKFAGGDDGAAAQRWKDLLVCERYALDAVRAAGFAAATAQWLDVEAYRFLEVTRFDRVGLRGRRPLLSLRAIDNEYLGLGGTWTRVAQGLLSARHISAEDARSVRWLDTFGQLIGNTDRHLGNLSFFVEGPRKFRLAPVYDMLPMVFAPQGTSLSEPRFVPAPPSADTLDVWGHAARCARDYWGTLASSPEFSGPFRERCLQAGEAVDRLIRQSPV
>NC_014623.1|WP_002617844.1|619076_620339_-|restriction-endonuclease
MTPWVLTEWEWAELPLSAEDLLAAQSYLGSALTAEPSARGFRLRAHGVAGMVALPGGVLHLRPQVPSLHLLALADYAAKGLSWGEDLVGMAEAEELLPLLGALFLRRVERLARGGWVHGYREEEAGQPVLRGRWLAGRDIAQPPTHRHRLTCRFDEFTRDVAPNRLLLAALRVLERARTFGPPVAARARALAATLDGVQARAEVHAAETMLASDRRFAAYGPAAKLARLILESTGVQAAPGPHPLSSFILRLAPLFEAAVTRALVQVAEARGLACHVQRPLVLDTEGRLLLVPDAVVEQGGARLVIDAKYKFPAKGLPPADDFQQIVTYLACVGTHRGALVLPALGAVPEEETLRLMTFGRTSQVRVVKVPLGGPAATLGRALESTAERLVSWLGNPPLPVLTGVLEPKIYSAFETSISK
>NC_014623.1|WP_013374188.1|620335_623077_-|EVE-domain-containing-protein
MNVLPPLPELVAQFLQRFIHQPAGQDHLARYATDAAFLRAAFEDICRRADAGEDVTERVLMKLLPHRDTPYNRQRGAWTTLWAIINREIQPWFQSVGWVPDAAAWRDIAAHLLRLLRTLERSPQPAALEAFAASPLSRGFRAGFLSPALHALRPDLYLAVNARSRRTAHFCLALWGESREVSVGLEHYLEATATLRFVLERLKPLGVQDANHFDAFCHWLCDRKLGGYLARRKVEELEEAPGDEAGGEPDEEIGAWVVRNMLSKRNFRAEIRRGRRSTWTALQRGSREWLRDAEPGDLVFLYQASPVREVLGLGKLASEPASVGDETRFEVEFLTDVLAQPIPLSAIQAHSTLSGMMMASPRSGMVLPIRADELPPLARLIRDRNPEVHEVLAPYLPAGALLPEPSPPHAPRVLELAAWVDEWRRTSGHPDDTDLREAAQREAWARMLAPEALGTLTPEDFRPVYQLGVLGSAGPLPALNRFFLEAGEPQLAHFRATLREVLHGEGRLEQRLDRALDRDSPAAVKGLSEPVLMKCLAVVHPERFLGIHCYEGDTGKARMMEMLGLPPLPDSLPVGTRAVRSNDALREALAHHLPGTADLPPTQAMRRFLYWLKARLDQQPPPKELDPAERFLHTTSLRRERLEELCALLEHRRQLILYGPPGTGKTYIARELARYQAGAETRCERVQFHPAYSYEDFVEGLRPQVDAQAPGGLRYEYRPGILKSLAERAQASPTERFVLLIDEINRGALPRVFGELLYLLEYREERVRLAGSGDFFELPTNLYLIGTMNSADRSIAQIDVALRRRFHFVRMDPDAEILRRNLLKWDVAPDVCDWAVQGLEAVNARIARSPGREFCIGHSFFMDKDLDPGRVERIWRHDIAPMLEDCFYDSPQVVPELRALFDAARPGPVDMSE
>NC_014623.1|WP_002617841.1|623245_624760_-|DUF4241-domain-containing-protein
MKHRHSPAVAVGLPSVNPRRNDLLAAFDGRRVLLDHGQPVRVSTHHAGTLVLTSGRVVACHPLCLPPSPVPKAHLLVLLSLNHREPFTRTVAPGRYPVLLSVLHTGRAGTPEARELVAMAMVQFEDTRPTRWELASRGEQGAQVPRPGPLHGPAAAPDMLAFLDADAVEQASQTSPAFLETAPSASPPSWSSAALTVDASSGANVIVFSPGRCPRAPRYPSAQSSWWGLAEDGRPVCLVTDFQHLDVTRPEFPDNPGARHARVRELVEHLRSADAHARGRALREVGGYGGEAREAVAPLLAFILAPGTDSAEREYAAAAVARICAEAPDQVERLTQAMCPPTRGEPLAVLLRAAAGIGLCHKCPETLQPVAERILAALLPQVAEEDPSVHGVIMGLIWDLGEQRPEAQALLVRLLDTARPELRVAAAARLKDSPVSAYQEAAMETLAGILHDRAIDPELHVAAVSSLGAFPQLTASARMALWHAASSPQPLLAWYARDLLRQRS
>NC_014623.1|WP_013374189.1|625016_625493_+|hypothetical-protein
MPRISNAQIQERNTFLLELIRSQPDISRDEARERFDEKFGATLNPKLFQELREQVLEERMGAAPVQEPVREEPPEEVPEEEAAPLKTSVGAFDGNGASGQPAKAKVKGKGQKNLFVDAPKEQLVFLERIVQQLQEAGASNVRIDHSTDRWMVLVVDPK
>NC_014623.1|WP_013374190.1|625549_627019_+|MFS-transporter
MRTTHRPLTTVALALSLFMAALEMTVVSTAMPTVVSDLGGLQSYAWVFTAYMLSSTITVPIYGKLSDLYGRKPVLLFGIGLFLVGSIASGLSTSMNMLIAFRVFQGLGAGAMQPVALTIVGDIYTLEQRAKVQGAFSAVWGVAGLVGPLTGGLIVKYLSWHWVFFINVPVGLGALALLIFFFHEKVQHKPQKLDFAGAVLLSAGVVALLFGVQGTGRSLLALPLGAVLLGAFVWVEGKVADPLLPMSLFKIPVIAIASVAGVFFSVAMFGSTAYVPLYVQGVLGGSPTEAGGMITPMIVGWPLASLVAGKLLLRTGPRPLIIGGLGLTVVGTALMALLLKPGASMLVPGLAMALFGIGLGFATTSLLIAVQTSVGWELRGVATASTMFFRTVGGALGVGLMGGVMVAQLMKDPRVSFSDANALLGPGHGQELSPVLLETLSGALRFGLTINFWIICGCTAAAFAVGLFFPRGGRDKGTVLPSTDVTVSH
>NC_014623.1|WP_013374191.1|627041_628697_-|DUF2339-domain-containing-protein
MNAEEEQGELRERVQRLEQLVTLLETRLHHLEGAGLRAPSTPPLTEASGPSVPVPGAEPRADLEAHLGTYWLSRLGIVALITGIAYLITYRFGELGMLVRVVLGYMLSAGLGALGLWISRRSLLFGRIVFGGGLALAYFVTYALHFIPSVRVIDNQVLALVLLAAFVLGIVVTAQRMHSETVAGIALFLGLHTGMLSDVTAFTLLSTTLLAMGALFFLVKNRWVIVPLSSLVSVYSTHTLWAVRAPGLAPGAPDTGRLLLSLSFLALYFLLFSVALLARPRELSARACLAFVSLNWVGLLALGAYEVQTRSAPHLFTFLLVTALAQGAGALVARWRQAPPPLLHAYLALGAITLALAMPAHFSATPLVVSWLVTGTGVGLAARALASPALRGLSVAILLVGLAAAQLTGTRPSALFAAAFACFLLVERLGEFRPAWLPPPEVFRGHGLLQALCAGGAGLSLVWLVGQEMPAGLITLGWALTASGMFAVGFAFHERRYRFVGIAGLALALGRLLLVDLSRLPTDQRVITFILLGVLLLLISYTYTRLKERKG
>NC_014623.1|WP_002612987.1|628884_629991_+|kelch-repeat-containing-protein
MSRVSKSFIAVMVFAGMFSCGSGRELDGRSPEGEGAALSSPRKRLPFVQLVDGRVLAAGGHDGTRTLSSCELFDPVSGTWSTTGSLRTARRNHAAAVLADGRVLVVGGAPAQLSGALASAELYDPATGGWMPVAPLSVPRIDPTVVTLADGRVLVVGGADVDQRLLRSAEWFEPATGTWHAAETSGWGHGGAQAAVVLLDGRVLFASGMQAELYEPSTGRWTKAGSAGGAAGTHRMGHTVTRLVDGRVLVVGGTTSRAAETAELYVPATGEWTLVAPLAMPREGHGALLTGDGDVLVVGGYHFASGTLASAERFEPVSGTWRPVNALQTPRQGAGLLRLPGDAVLVVGGFNDAVETLTSSERYVPGGE
>NC_014623.1|WP_002613002.1|630037_631429_+|aminopeptidase-P-family-protein
MRPLSLAVFLSALMVFPACATVAAPPAAPGGALPERPFGTLQEQALRQQAWLRERLEVALPHLMRQHRIEMWVVPMREYNEDPVFKALVSPTTYSARRRTIYVFQDLGAQLGVSRVALGGGSQGGVYEVRRPPVKVEGGGGERVAEPWGPEQWQMLKQLLEERQPRTIAIDVSRVFAFSDGLTHGEYEGMVEALGPEWAARLKPSGGLPVDVLAWRSADEERFFAQENQLAWDIIQTAFSNAVITPGTTHVSEVEWWMVQRLNDLGLATWFHPSVSVQRQGAGEAPLGEDPVIQRGDVLHCDFGITALRLNTDTQHMGYVLREGETEVPEGLRQALARSNRLQDLVVEELRPGRTGNEVLRASLSRMREEGIEGTVYSHPVGLHGHGAGSMVGLWDRQQGVPGNGDHPIIPSMWYSIELQATSPVAEWGGQKVRSAQEEDVIIGADGQVRWAWKRQTAFHVVR

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Crispr_ID: NC_014623_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014623_4

2723196-2723609

Orphan

Consensus_repeat	Method
GGCTACACGGGCCCCGTGGATGGGGTCATGGGAACCAAC	CRISPRCasFinder

5 spacers

The CRISPR arrays of NC_014623_4

>merge|NC_014623|4|2723196-2723609|CRISPRCasFinder
GGCTACTCGGGGCCGGTGGATGGCGCCATGGGCACGAACTCGTGGAAGGCGCTCCAGCGTTTCGCCGCGAAGGGGGGCTACACGGGCCCCGTGGATGGGGTCATGGGAACCAACGGCTGGAAGGGCGTGCAGACCGTCCTGAAGGGTTTTGGCTACACGGGCCCCGTGGATGGGGTCATGGGAACCAACTCCTACGCGGCCCTTCAGCGGGTCGCGCGCTTGGGCGGATACATGGGCCCCAGTGATGGCGTCATGGGGGTGAACTCGTGGAAGGGCCTCCAGACCTTCCTGAGCGGCGCTGGATACACGGGACCCATCGACGGCGTGCCGGGATCGAATACCTACAAAGCGCTCCAGTCCCTGGCGAGCCGGGGCGGCTACGCAGGCCCGCTCGATGGCGTTCCCGGAAGCAAT

>NC_014623|4|4|2723196-2723609|CRISPRCasFinder
GGCTACTCGGGGCCGGTGGATGGCGCCATGGGCACGAAC	TCGTGGAAGGCGCTCCAGCGTTTCGCCGCGAAGGGG
GGCTACACGGGCCCCGTGGATGGGGTCATGGGAACCAAC	GGCTGGAAGGGCGTGCAGACCGTCCTGAAGGGTTTT
GGCTACACGGGCCCCGTGGATGGGGTCATGGGAACCAAC	TCCTACGCGGCCCTTCAGCGGGTCGCGCGCTTGGGC
GGATACATGGGCCCCAGTGATGGCGTCATGGGGGTGAAC	TCGTGGAAGGGCCTCCAGACCTTCCTGAGCGGCGCT
GGATACACGGGACCCATCGACGGCGTGCCGGGATCGAAT	ACCTACAAAGCGCTCCAGTCCCTGGCGAGCCGGGGC
GGCTACGCAGGCCCGCTCGATGGCGTTCCCGGAAGCAAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_014623.1\|WP_002618479.1\|2711248_2712769_-\|hypothetical-protein	unknown	unknown	unknown
NC_014623.1\|WP_148273319.1\|2725747_2726125_+\|hypothetical-protein	unknown	unknown	unknown
NC_014623.1\|WP_002610255.1\|2728151_2728505_-\|DUF1428-family-protein	unknown	unknown	gnl\|CDD\|227794
NC_014623.1\|WP_002618469.1\|2709052_2710066_+\|hypothetical-protein	unknown	unknown	unknown
NC_014623.1\|WP_013375099.1\|2723747_2724842_-\|glycoside-hydrolase	unknown	unknown	gnl\|CDD\|367601
NC_014623.1\|WP_002618475.1\|2710885_2711230_+\|hypothetical-protein	unknown	unknown	unknown
NC_014623.1\|WP_037582978.1\|2728589_2729030_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224759
NC_014623.1\|WP_002618471.1\|2716600_2717116_+\|hypothetical-protein	unknown	unknown	unknown
NC_014623.1\|WP_037584286.1\|2717137_2718007_-\|formyltetrahydrofolate-deformylase	unknown	unknown	gnl\|CDD\|235676
NC_014623.1\|WP_002618473.1\|2710205_2710736_+\|hypothetical-protein	unknown	unknown	unknown
NC_014623.1\|WP_002610405.1\|2729080_2730001_-\|hypothetical-protein	unknown	unknown	unknown
NC_014623.1\|WP_013375103.1\|2731996_2732902_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176114
NC_014623.1\|WP_002618467.1\|2719594_2720647_-\|hypothetical-protein	unknown	unknown	unknown
NC_014623.1\|WP_002618474.1\|2718147_2719557_+\|deoxyribodipyrimidine-photo-lyase	unknown	unknown	gnl\|CDD\|129679
NC_014623.1\|WP_002610287.1\|2730155_2731898_+\|DUF4215-domain-containing-protein	unknown	unknown	gnl\|CDD\|162730
NC_014623.1\|WP_002610403.1\|2724933_2725578_-\|glutathione-S-transferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|372593
NC_014623.1\|WP_002618466.1\|2712915_2713599_+\|RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|224511
NC_014623.1\|WP_002610373.1\|2727369_2728140_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|225861
NC_014623.1\|WP_013375101.1\|2726211_2727123_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366181
NC_014623.1\|WP_002618472.1\|2713595_2716529_+\|CHAT-domain-containing-protein	unknown	unknown	gnl\|CDD\|378942

Protein	Function_ID	Function_description	E-value
NC_014623.1\|WP_037584286.1\|2717137_2718007_-\|formyltetrahydrofolate-deformylase	gnl\|CDD\|235676	PRK06027, purU, formyltetrahydrofolate deformylase; Reviewed.	4.49487e-178
NC_014623.1\|WP_013375099.1\|2723747_2724842_-\|glycoside-hydrolase	gnl\|CDD\|367601	pfam03663, Glyco_hydro_76, Glycosyl hydrolase family 76. Family of alpha-1,6-mannanases.	1.36971e-28
NC_014623.1\|WP_002618466.1\|2712915_2713599_+\|RNA-polymerase-sigma-factor	gnl\|CDD\|224511	COG1595, RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription].	5.12285e-31
NC_014623.1\|WP_037582978.1\|2728589_2729030_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|224759	COG1846, MarR, Transcriptional regulators [Transcription].	3.74298e-17
NC_014623.1\|WP_002610255.1\|2728151_2728505_-\|DUF1428-family-protein	gnl\|CDD\|227794	COG5507, COG5507, Uncharacterized conserved protein [Function unknown].	1.34511e-61
NC_014623.1\|WP_013375103.1\|2731996_2732902_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176114	cd08422, PBP2_CrgA_like, The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain. This CD includes the substrate binding domain of LysR-type transcriptional regulator (LTTR) CrgA and its related homologs. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis further showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	7.91647e-78
NC_014623.1\|WP_002618474.1\|2718147_2719557_+\|deoxyribodipyrimidine-photo-lyase	gnl\|CDD\|129679	TIGR00591, Deoxyribodipyrimidine_photo-lyase, photolyase PhrII. All proteins in this family for which functions are known are DNA-photolyases used for the direct repair of UV irradiation induced DNA damage. Some repair 6-4 photoproducts while others repair cyclobutane pyrimidine dimers. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair].	1.56282e-112
NC_014623.1\|WP_002610403.1\|2724933_2725578_-\|glutathione-S-transferase-domain-containing-protein	gnl\|CDD\|372593	pfam13409, GST_N_2, Glutathione S-transferase, N-terminal domain. This family is closely related to pfam02798.	0.000493516
NC_014623.1\|WP_002610373.1\|2727369_2728140_-\|VOC-family-protein	gnl\|CDD\|225861	COG3324, COG3324, Predicted enzyme related to lactoylglutathione lyase [General function prediction only].	1.52579e-27
NC_014623.1\|WP_002610287.1\|2730155_2731898_+\|DUF4215-domain-containing-protein	gnl\|CDD\|162730	TIGR02148, ORFveg106_random, fibro-slime domain. This model represents a conserved region of about 90 amino acids, shared in at least 4 distinct large putative proteins from the slime mold Dictyostelium discoideum and 10 proteins from the rumen bacterium Fibrobacter succinogenes, and in no other species so far. We propose here the name fibro-slime domain.	8.3532e-28
NC_014623.1\|WP_013375101.1\|2726211_2727123_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	6.83562e-15
NC_014623.1\|WP_002618472.1\|2713595_2716529_+\|CHAT-domain-containing-protein	gnl\|CDD\|378942	pfam12770, CHAT, CHAT domain. These proteins appear to be related to peptidases in peptidase clan CD that includes the caspases. This domain has been termed the CHAT domain for Caspase HetF Associated with Tprs. This family has been identified as a sister group to the separins.	5.77275e-14

>NC_014623.1|WP_002618467.1|2719594_2720647_-|hypothetical-protein
MYKLNTLSSSPAATNRLASAPLSPAATNRLAVPQTAELARVAHPNGALGTSGLRGRPVDSFEAGGLSGARIGLARNGARNALEGAAPQAPQAPAKAPPRLAEDGTEIPGPNDTRPPGDNRSAADIVNDSPVLSKLGRQKDIKFDQLCKQTGVDPNIDLKDSRQNPDAVYRMTKVLEYIDSSKISDGGERTGKVQGGQGDGNIEGITKDGDARHGTEAGMLKDFAEKGYDSLGTDHRLPVTSDTHVKKDGSNKDNFQWFAGEAGKNLWFIPGVSNVLTGIGESEGGALGAIEGGLGGMVKTWKGAAEGVIGSLMGGKPNPLSMALGAYTGALQETDAAPDVVKDIASMLPF
>NC_014623.1|WP_002618474.1|2718147_2719557_+|deoxyribodipyrimidine-photo-lyase
MARRKVEESRLKRLKDHAAKGGDYVLYWMQQSARAEHNPALEYAIQQANAAKLPLLVGYGLMDGYPEANVRHYRFLLEGLQDCQRTLAHRKIPFALQRGPPDEVALKLSRQAALVVCDRGYLRHQKQWRQTLAAKASCPVVQVEADVVVPVEAASGKAEYAARTLRPKIHRLWEEYLVRPTSTPLEVDSLKLGVKGLNLDDVGAVLDRMALDRSVPPVHHFFRGGTSEAKRVLRGFVTRHLPEYQENRPHPETDHVSHMSKYLHFGQISPVVVALAAREARALRPQRDTFLEELIVRRELAQNFAEYTPQYDDYTSLPAWARKTLAAHAGDKRPFHYTKAQLEQARTHDPYWNAAMREMRYTGYMHNAMRMYWGKKILEWGRTPEEAYRTALTLNNTYFLDGRDANSFTNIGWVFGLHDRPWGRRAIYGTVRSMSAKGLERKADMEAYLAKVDALVEEAKAAGVRFAED
>NC_014623.1|WP_037584286.1|2717137_2718007_-|formyltetrahydrofolate-deformylase
MTTQFETTARLLITCPDRPGIVSAVTTFLYHHGANVTELDQYSTDPSGGRFFMRLEFQTPHLDVSRATLKQSFGDVVGQRFEMDWRLSFAADKPRMGVLVSKHDHALMDLLWRWQRGELRVDLPLVISNHPDLREAVERFGVRFEHVPVEAATHAESEARMLALLEGQVDFVVLARYMRILSAGFVSHYPQRIINIHHSFLPAFVGADPYKQAYERGVKLIGATAHYVTSELDQGPIIEQDTARVSHRHAVPELRHLGRDLERQVLARAVRWHAEDRIIVDGNKTIVFA
>NC_014623.1|WP_002618471.1|2716600_2717116_+|hypothetical-protein
MKRELLLTLLTVGTATSALAKEPPRVTTTPQVPQTPQATVPVQSATPKAVLATPVAEPSYFDIVASDDRGHRVATYRFIRRTREIVVLKPSREIEDIAAFSKISSPGDYVIAVAPEKKPKPNPPNPGEELRTSWTVPRAELQEAMTKVQAKVPAAKGFFVGQFAEDVALGK
>NC_014623.1|WP_002618472.1|2713595_2716529_+|CHAT-domain-containing-protein
MTPACEQLAAFVDGELSPQEAAAFQEHLTGCEDCQAGLMDQVQASVAVHAAGETSRKGTRTPFQPMWAQRRTRVLAYSVGAVAVLLLGVLAVRGAGAPPKDPLLLAMAETRPLEGWLSYPGADRHRPLATMRSGAVGTAALDHRILAELEDRGDFHGVATAYLRAGEFARAEQFLDRVPSSPEVDSDRALAALGRGEHERALGLLEHALAAAPESLRVHWNRGVVLRAMSLELAASAEFQQVADKAEPGWSEEARQLAGGLRATAEARRQSWQSLTEAGQALAFQGTPMPATMVHRNPGRVRLYLYHALRTAVSREQVLALLPLAQSLDQVSRTRTASSSVQSVAQANFTKRAPLAETYRALLSDPGALPPPAAAAYLERLRRSGEQDLLLGAILLLGAERRHLAEVERLVQGSEDVLWYRGPLVKAQASEEMARGAGLAAEQRLRDAVEEYRRAGLDYRSISLQEELSTLYNKLDRRREAMQVAREALEAARRTDDWFHEDLLVFDLVTSARLSHEPALARAYLDEYLRRSPEDCARRAEYHYFRALLAVEALDATGARREVAQAQTCPAAPTLFEIAVYGDLLRFGATEAERARAEDRIRLLRQDTSLEPDQRLLLEHLAGRILIERDRPAGQRILREVIAGAEPLRATHIEARKAWSHSYQALVRDAGKAGEFDAAIALLSAELERAAPPACLLAVAGQDERVLFVARGPQGDLRGAYLEGLTRSLHETVPPVPAALRAVLEGCDTVKVLAEPLLQGRPGLLGPDQAWSYLAPKVRGPHAPAAGTSFKHVVVSAVEPPASLGLPHLLPWSRPPELGEVHLRGPSATPEAVLAELTDATQVEFHAHGLSRLGFSDASFLALSPGADGRYALTAADLQGRSLRGAPLVLLAACEANVGALRYHDVWSLPAAFVQAGASSVVAPSSLVPDAEVGTFFQELLERVDGGATAAQALRDTRVAWLQKKPTRWVEDLVVFE
>NC_014623.1|WP_002618466.1|2712915_2713599_+|RNA-polymerase-sigma-factor
MQAREPVESLLRWVPSVPSSFPVEFPFRSASSRSRQRAREPEASGDPRPSAPAAGDAAEFQRVLASCEAKLEERARFLCRGRNPSDARDLLQDTYERAFRAFHTYDRNAPPMPWLASILVRRFLDMCRHDKRHPEQEFTEALDQAREEAEPAEPWGGYTLDDVWRAVDLLPEEFRDVVRLKDMEGLSYAQIGKRLGIAPMTVGTRIFRARKKLKEILLKQAEKGGGR
>NC_014623.1|WP_002618479.1|2711248_2712769_-|hypothetical-protein
MDRPVHSVRARLDDFLADLANLHYRHGAGLSPELPVAALHASFPELSSAETFAAATEALEKARAKNEPLGVRRLQLLRELIAGQVEEGLAARDVEAVAKLEAHARMALDDQALSFGEALAQIPHEPNRGRRALLERAVGNFLWSEKGRYGARREAALQTAEQLGAQDYPTLREDVSGIALGKLVEAANETLRLTEDAYRDVLGYVLHKIDPTLRALPGGNARRHDLQAALQAPWMDSFFLREGLAPAVMRWLNDWNFPPTARGRIRIDDEPRPGKAHRPFVAAVHVPGEVRLVLQARGGMDALGDLLHECGHAQHLAHIAETLPVELRRLGDASVTEGFAALTERLLLSSEWLKRYLQLPTPVAKDAVRLAAFQALAVLRRHCAKLPYEMSLFTRGPSEERAEEYAAGQRRALFVEPHPGYFLFDVDPQLYSARYLRAWALEARLTARLRERFNEDFWRNPAAGEWLKGLFAKGGTDDAETLSTEISGTPLALPEAGARLVAILNH
>NC_014623.1|WP_002618475.1|2710885_2711230_+|hypothetical-protein
MERKVGSSTVTTKEVKTALEKARTLTSEEEKVLRMRHGAGAPSPRAPLPRAAGNNEELADELLVIEMQLMKAMRARTGQVKTGSKSTVKAAAPAKEPAKNAAKEKIVRALRKKK
>NC_014623.1|WP_002618473.1|2710205_2710736_+|hypothetical-protein
MRCVWVFLMVCWGGWAGPAWAGSAQSLALTFSPVGGFLLTQAADGKAGGYSMEVGWSYRRTQALVEVGGHVASSRLLTAATPVSVRLTPFREARLRPSLGLGASFLIPHVRAVARQEGHPGLLVGLELSAGLELGLGEGWFLCSEAYYQNFSAEPEPLSGERQGMSSVFLGVGFRL
>NC_014623.1|WP_002618469.1|2709052_2710066_+|hypothetical-protein
MSRFKRSALVAALALSACSDPVDKAAKARIFSAEDPPKVVASAAEKLPPEDVADNPLVARRILGMDAAEVTERLGPYTYKATLSYEWTTGDAPPVKVSETRTFQAGPGGVSGDFHGVLENSRDQGLEVMRVEGKVYARNRYGTFRQRLRDRGMAERTRTELTGAIRDVDSLFQGRLQLTPQGTVIYEGRTAWRYDVKLGEASEAPAVGNLPAVLDPKGGRDETTRRRLAFFEHRVPQSLVGEVLVDAETSVVLKVRLNGHLVVPAGKAAEGAELRMSLNSDLSGIGQDPQLKPPENFLPDADKPQGIADALDRFGIPRNKADGGTAGAAGPAEPEDE
>NC_014623.1|WP_013375099.1|2723747_2724842_-|glycoside-hydrolase
MNWRLLTLLVVPLALAYAPGAIALTPTEKNLAFDSYNNAFYVANGGNGYYVVDTNRGAPGRFHFWKVCEQIEAAEDAYDRTGNPAYRTLVASLLNGLNNVISGTTDFASWNEYNDDVMWAVIALTRGYEITGNRAFLDQAQWQFNKVWSRAWDNQLGGGFWWRADKQTKNACVAGPATIAAMLLARNTVNTGYRSQADQIYNWLRSTLYNPSTGQVADHIQANGTKVWWAFTYNQGTFAGASTLLYQATGNASYRDAGGLAVNWTRRNLTGQHLADILNDEYDANGGSGDTAGFKGIFVRWASKWAGAANDASIKSWLSTNANTAWSYRNSSGVMWGQWWRRTPDNYVTSWEASPGLAVSQIPY
>NC_014623.1|WP_002610403.1|2724933_2725578_-|glutathione-S-transferase-domain-containing-protein
MPDALEAFAQPTLVGRSSSHFTRVARIFAAEMHIDYSFQIVRDLMSSDPGDYGGNPALRIPVMRTSRGVWFGALNVCRELWRQSSLKPRVVWPEQLDEPLLANAQELILQAMATEVTLIMSTLADASGANAHHAKMRTGLVNMMSWLEENAKSVLAALPPHRDLSFLEVTLFCLVTHLEFRSVLPMAPYSELKHFCQHFATRASIGETPYRFDP
>NC_014623.1|WP_148273319.1|2725747_2726125_+|hypothetical-protein
MDSLQEELSSVDVIRPEMKRMTDATTTNSQGALEATRVIPSTARIRAISWLVSGAYAQLHKSPSMRMRLSVTRGSAQYLSVGGASTVQWVDFVAPETGSYAITIQRTFNSGVGDVALALSVGEVV
>NC_014623.1|WP_013375101.1|2726211_2727123_+|MarR-family-transcriptional-regulator
MSSHTAILRRFNRTYTQRIGALDESFLGLGWPLGVSRLVFEIGSAAGVGTAVRDLRERLELDSGYLSRLLRRLEDAGVVKVRPDPGDRRRRVATLTARGRRVWQELEARSEALAQALLAPLTGRQRARLTEALATADLLVRVATVRLRNVSPGDPLAAEAVGRYFAELDARFPGGFDPGDAATTDAASMGAGAGIFVVATSDGQPVACGGVQQIGEGVGEIKRMWVHPEWRGAGLGSRLLLHLEEEAARLGHTRICLDTHDTLTEAIAMYARAGYAPVERYNDNPYARHWFAKDVPRRGRAGR
>NC_014623.1|WP_002610373.1|2727369_2728140_-|VOC-family-protein
MANHRGDFIWYELLTSNTRAAADFYGAVIGWRSHTPDGMRGYTLFGAGETDVAGLLAIPTEAASAGQRPIWLGYIAVDDVDEAVSSIVAAGGTRHVPPTDIPGVGRFSMVADPQGVMFYVMRGAVDGTSTSFHAEKTGHCQWNELATNDPVAALAFYSGRFGWTKGDAMPMGDMGDYQFFKQNGQMVGAVMARKPGAPPMWTFYFGVDDIDVATKTASSKGAKIHYGPAEIPGGSFIIIADDPQGATFGLVGPRKR
>NC_014623.1|WP_002610255.1|2728151_2728505_-|DUF1428-family-protein
MKYVEGFVAAVPAANKEMYRQHAAEAAPLFKEFGATRMVECWGDDVPNGQLTDFRRAVQAKDDEVVVFSWFEYPSKEVRDAANERIFNDPRMKALGTQMPFDAKRMIFGGFVPILDI
>NC_014623.1|WP_037582978.1|2728589_2729030_+|MarR-family-transcriptional-regulator
MSRLVPFEATLEVRDACLCLHVQRAARALARRFDEALRPVGLTHGQFSLMMALNQPRSPTLGAVARLLAMDRTTLTAALKPLERDGLVSIQAAPDDRRSRLLTLTGKGLEVLASAVPIWRDTHAAIEAGLPRAWPDALRAGLLALS
>NC_014623.1|WP_002610405.1|2729080_2730001_-|hypothetical-protein
MGVDSVGGSSSSRGSSSSVSDNASKSSQTSQTSASTQAAAEADKKAAEAAAVEKAAITAQTNFNVSSFTAATPTAGMPSLTAPQFTANMLSPTPVENVPTLTAPDFAANLTQATPMGPLGAFEKPAPIPQARPEVAPQTANLTYGPKADAAAVSAHSQAVLGEIMASAGVTSATISSTARTPEDQARAMYDNLQAKGIASQKDLYSKFGDQVIDSYAAAVDAGLTKEQTLQAMVDKINELGPSNVSRHLADPSQLNVVDIAPSSIPADKREAFQEAIRAHPEVSKFLGPADGDPAYHIEIRQPQPQ
>NC_014623.1|WP_002610287.1|2730155_2731898_+|DUF4215-domain-containing-protein
MSDAQCPTSLSRFAVFSLLLVLTACGGGNPTDPKPDGGGPGDTPDASTDGGRDGGGPVDPLDCGNGILQAGETCDDGNLSNEDGCSSACSVESGWICRTPGQPCVLNVCGDGVRGPKETCDDFNTRSGDGCSATCAVEAGWNCPSGGGNCQAARCGDNIVAGDEECEDGNAAAGDGCSATCRLEAGFKCPVAGQACSRTTCGDTKVEGTEQCDDGNNDMGDGCSPLCTREPSCTNGTCTAICGDNLILPGNTTEECDDGNLRDNDGCSSTCKLEPGFQCKQIESDPPAFVEIPVVYRDFIGNDQTHAQKHADFENKNGSEKGLVKADLVNNKPAYAKTTGGSTTTNGEALFNQWYKDSSRSKTEVSTLRLTRQGTSSSYVFDNPDFFPLDNKGWVATGEEPRRNNNHNFSFTSEARYWFEYKGTEVLSFRGDDDVWVFINKKLAVDLGGVHGAENGSVDLTLPAGTTVNTKYSMNKGGIYEAVVFQAERHTTASSYKLTLANFTTRRTECTSSCGDGVVQPPEECDSGTNPGGYGQCAPGCIFGPRCGDGIVQEAFGESCDDGNDDNDDLCSNTCKPRIG
>NC_014623.1|WP_013375103.1|2731996_2732902_-|LysR-family-transcriptional-regulator
MAFDGKLLSGMGVMAAVVEAGNFVRAAEALGLTQSGVSRAVARLEQRVGVRLFDRTARAVSLTDEGRRFYEEVAPHLAGIEDAATAATGAAATVRGHLRVNADAAFGHYVLAPRLGEFLALHPELSFELVVRDRIGDLVAEGLDMAVRFGEPEPSSLICRQIGRSQVLTCASPEYVARRGRPKHPSELARGAHECILVRNTWTGRHFDWEFHQGREVVQVDVQGRLMVNDSGSLISAMLSGHGVGQPFEFSVRELIDSGRLVKLLPAWSDERYPVHVYHRSREFPAAKVRAFIDFLRTLTA

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Crispr_ID: NC_014623_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014623_5

3291973-3292071

Orphan

Consensus_repeat	Method
GGGAATGGCGTTGGACTGGGGGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014623_5

>merge|NC_014623|5|3291973-3292071|CRISPRCasFinder
GGGAATGGCGTTGGACTGGGGGGCCGCGCCGGGCAGGGGGATGGCGGCGGACGGGGCGGCCACGGCGCCCGGCAACGGGATGGCGTTGGACTGGGGGGC

>NC_014623|5|5|3291973-3292071|CRISPRCasFinder
GGGAATGGCGTTGGACTGGGGGGC	CGCGCCGGGCAGGGGGATGGCGGCGGACGGGGCGGCCACGGCGCCCGGCAA
CGGGATGGCGTTGGACTGGGGGGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_014623.1\|WP_013375388.1\|3282400_3283939_-\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224154
NC_014623.1\|WP_013375394.1\|3302232_3304266_-\|ATP-dependent-DNA-helicase-RecQ	unknown	unknown	gnl\|CDD\|223588
NC_014623.1\|WP_013375386.1\|3280168_3280870_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237871
NC_014623.1\|WP_002617568.1\|3296521_3297445_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187551
NC_014623.1\|WP_041791853.1\|3304582_3305350_-\|DNA-repair-protein-RadC	unknown	unknown	gnl\|CDD\|178801
NC_014623.1\|WP_148273592.1\|3304268_3304574_-\|DUF3006-domain-containing-protein	unknown	unknown	gnl\|CDD\|378598
NC_014623.1\|WP_013375389.1\|3285860_3286325_-\|nucleoside-deaminase	unknown	unknown	gnl\|CDD\|223663
NC_014623.1\|WP_002617570.1\|3284049_3285495_+\|mannosyltransferase	unknown	unknown	gnl\|CDD\|281842
NC_014623.1\|WP_086016059.1\|3275473_3277396_+\|FecR-domain-containing-protein	unknown	unknown	gnl\|CDD\|377406
NC_014623.1\|WP_013375384.1\|3279156_3279750_-\|recombination-protein-RecR	unknown	unknown	gnl\|CDD\|234616
NC_014623.1\|WP_002617567.1\|3294598_3295540_+\|polysaccharide-deacetylase-family-protein	unknown	unknown	gnl\|CDD\|200565
NC_014623.1\|WP_013375385.1\|3279756_3280074_-\|YbaB/EbfC-family-nucleoid-associated-protein	unknown	unknown	gnl\|CDD\|376829
NC_014623.1\|WP_013375383.1\|3277407_3279150_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_014623.1\|WP_002617578.1\|3295635_3296490_+\|acyltransferase-family-protein	unknown	unknown	gnl\|CDD\|153249
NC_014623.1\|WP_002617574.1\|3293874_3294585_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133022
NC_014623.1\|WP_013375390.1\|3286754_3288035_-\|serine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235461
NC_014623.1\|WP_002615550.1\|3305468_3306332_-\|NAD-dependent-protein-deacetylase	unknown	unknown	gnl\|CDD\|238700
NC_014623.1\|WP_148273336.1\|3281054_3282281_-\|DNA-polymerase-III-subunit-gamma/tau	unknown	unknown	gnl\|CDD\|237871
NC_014623.1\|WP_037584072.1\|3292465_3293782_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224153
NC_014623.1\|WP_002620489.1\|3301878_3302220_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_014623.1\|WP_013375388.1\|3282400_3283939_-\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224154	COG1233, COG1233, Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism].	3.20436e-72
NC_014623.1\|WP_013375394.1\|3302232_3304266_-\|ATP-dependent-DNA-helicase-RecQ	gnl\|CDD\|223588	COG0514, RecQ, Superfamily II DNA helicase [DNA replication, recombination, and repair].	1.22268e-159
NC_014623.1\|WP_013375386.1\|3280168_3280870_-\|hypothetical-protein	gnl\|CDD\|237871	PRK14965, PRK14965, DNA polymerase III subunits gamma and tau; Provisional.	7.69303e-22
NC_014623.1\|WP_002617568.1\|3296521_3297445_+\|SDR-family-oxidoreductase	gnl\|CDD\|187551	cd05240, UDP_G4E_3_SDR_e, UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs. Members of this bacterial subgroup are identified as possible sugar epimerases, such as UDP-glucose 4 epimerase. However, while the NAD(P)-binding motif is fairly well conserved, not all members retain the canonical active site tetrad of the extended SDRs. UDP-glucose 4 epimerase (aka UDP-galactose-4-epimerase), is a homodimeric extended SDR. It catalyzes the NAD-dependent conversion of UDP-galactose to UDP-glucose, the final step in Leloir galactose synthesis. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	9.24976e-124
NC_014623.1\|WP_041791853.1\|3304582_3305350_-\|DNA-repair-protein-RadC	gnl\|CDD\|178801	PRK00024, PRK00024, DNA repair protein RadC.	6.52167e-79
NC_014623.1\|WP_148273592.1\|3304268_3304574_-\|DUF3006-domain-containing-protein	gnl\|CDD\|378598	pfam11213, DUF3006, Protein of unknown function (DUF3006). This family of proteins has no known function.	0.000105567
NC_014623.1\|WP_013375389.1\|3285860_3286325_-\|nucleoside-deaminase	gnl\|CDD\|223663	COG0590, CumB, Cytosine/adenosine deaminases [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis].	1.76327e-62
NC_014623.1\|WP_002617570.1\|3284049_3285495_+\|mannosyltransferase	gnl\|CDD\|281842	pfam03901, Glyco_transf_22, Alg9-like mannosyltransferase family. Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.	1.4946e-21
NC_014623.1\|WP_086016059.1\|3275473_3277396_+\|FecR-domain-containing-protein	gnl\|CDD\|377406	pfam04773, FecR, FecR protein. FecR is involved in regulation of iron dicitrate transport. In the absence of citrate FecR inactivates FecI. FecR is probably a sensor that recognizes iron dicitrate in the periplasm.	9.22629e-07
NC_014623.1\|WP_013375384.1\|3279156_3279750_-\|recombination-protein-RecR	gnl\|CDD\|234616	PRK00076, recR, recombination protein RecR; Reviewed.	2.13749e-116
NC_014623.1\|WP_002617567.1\|3294598_3295540_+\|polysaccharide-deacetylase-family-protein	gnl\|CDD\|200565	cd10940, CE4_PuuE_HpPgdA_like_1, Putative catalytic domain of uncharacterized bacterial polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA). This family contains many uncharacterized bacterial polysaccharide deacetylases (DCAs) that show high sequence similarity to the catalytic domain of bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA). PuuE allantoinase appears to be metal-independent and specifically catalyzes the hydrolysis of (S)-allantoin into allantoic acid. Different from PuuE allantoinase, HpPgdA has the ability to bind a metal ion at the active site and is responsible for a peptidoglycan modification that counteracts the host immune response. Both PuuE allantoinase and HpPgdA function as homotetramers. The monomer is composed of a 7-stranded barrel with detectable sequence similarity to the 6-stranded barrel NodB homology domain of DCA-like proteins in the CE4 superfamily, which removes N-linked or O-linked acetyl groups from cell wall polysaccharides. In contrast to typical NodB-like DCAs, PuuE allantoinase and HpPgdA do not exhibit a solvent-accessible polysaccharide binding groove and might only bind a small molecule at the active site.	1.19069e-95
NC_014623.1\|WP_013375385.1\|3279756_3280074_-\|YbaB/EbfC-family-nucleoid-associated-protein	gnl\|CDD\|376829	pfam02575, YbaB_DNA_bd, YbaB/EbfC DNA-binding family. This is a family of DNA-binding proteins. Members of this family form homodimers which bind DNA via a tweezer-like structure. The conformation of the DNA is changed when bound to these proteins. In bacteria, these proteins may play a role in DNA replication-recovery following DNA damage.	5.29284e-28
NC_014623.1\|WP_013375383.1\|3277407_3279150_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	5.29228e-95
NC_014623.1\|WP_002617578.1\|3295635_3296490_+\|acyltransferase-family-protein	gnl\|CDD\|153249	cd07987, LPLAT_MGAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.	2.87689e-43
NC_014623.1\|WP_002617574.1\|3293874_3294585_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|133022	cd04179, DPM_DPG-synthase_like, DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily. DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.	2.05721e-36
NC_014623.1\|WP_013375390.1\|3286754_3288035_-\|serine--tRNA-ligase	gnl\|CDD\|235461	PRK05431, PRK05431, seryl-tRNA synthetase; Provisional.	0
NC_014623.1\|WP_002615550.1\|3305468_3306332_-\|NAD-dependent-protein-deacetylase	gnl\|CDD\|238700	cd01409, SIRT4, SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.	8.75222e-127
NC_014623.1\|WP_148273336.1\|3281054_3282281_-\|DNA-polymerase-III-subunit-gamma/tau	gnl\|CDD\|237871	PRK14965, PRK14965, DNA polymerase III subunits gamma and tau; Provisional.	0
NC_014623.1\|WP_037584072.1\|3292465_3293782_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|224153	COG1232, HemY, Protoporphyrinogen oxidase [Coenzyme metabolism].	2.80836e-43

>NC_014623.1|WP_013375390.1|3286754_3288035_-|serine--tRNA-ligase
MLDLRYVAQNFDAVVARLKARSGNLDLGPFQKLFTERRELYVSVEGLSARRNAANDEMKRKAKEDPKALDALRGDLRAVSQEIKEKEARLKEVEEEISRILLLIPNIPHESVPTGASEQDNVVTRTWGEKPDFLFTPRQHFEIGEKLGMLDFERAAKVSGSRFTFYKAALARLERALVTFMIDVHTQKGYTELLPPYLVLRETMMGTGQLPKFEDDAFKTSGDPERFLIPTAEVPVTNYHSDEILEGGQLPLKYCAFSPCFRAEAGAAGRDTRGLIRQHQFHKVELVKFATPETSLSELEGMTDDACDILRRLGLHHRVMLLCTGDMGFAARKTFDIEVWLPGQGAYREISSCSDCGDFQARRAKIRYRAQKGDKPQLLHTLNGSGLAVGRTSIAILENYQREDGSVAIPDALVPYMGGLKEIRPL
>NC_014623.1|WP_013375389.1|3285860_3286325_-|nucleoside-deaminase
MSDEAFMQQALALAREAEALGEVPVGAVAVHQGQVIGTGFNRREIDRHPFAHAELLALDAAARSLGVWRLTGVTLYVTLEPCAMCAGAMVQGRVTRLVFGTLDPKAGAAGSLYNLVEEPRHNHRLQVTSGILADESRQLLKGFFERLREKKRDK
>NC_014623.1|WP_002617570.1|3284049_3285495_+|mannosyltransferase
MTTSTPPPMTESPVPLPSEAVTPLAAPVGRGWLWVLGAVALAPAVLAVAQLGRIHPDEVYQTLEPAWFRAHGYGVLAWEWRDGLRNWAVPLLASWLLRLADLLGITHPQAYRAVLALPQVALHGWMLMATYRFAQRRGGQRTALLATLLVGLYGPVLVFAGRTMSESLSAAFLVVGLEALDRKERLDSAGWLGGLALGLAVVTRYGSAVFVAAALVGLVLASRWRTLAFTCAGGALVALALGALDALTWGTPFHSFLAYVRFNVLSGGAARQFGANPPGFYIPVLLGALPLWAWGSLGLALRQRRRLPSLPVFCAAVYGVAVSATAHKEERFLYPALVLLGVAAAPSLAAWLLEERWPTWLRRGGVALALAATLLPAAFYPPADLRGDQFRAIVAATRDEGATGLLIVNEGLWGSGGYFYIGKNIPWLNCDWPYERNFRAAMKHRAINRAVTFQGRALQELQAAGFRVVGQVGRETILARD
>NC_014623.1|WP_013375388.1|3282400_3283939_-|NAD(P)/FAD-dependent-oxidoreductase
MPDVIIVGAGHNGLVTAALLARRGLKVTVLEDKDTVGGACKTEYPFRSAPKLGVSTGAYLLGLMPPEILRELELELPLRRRDPHYFLPTTDKRYLLFGSNEREMQRQFLEFFSEADWKANQAMNAELAAMRDDLAPAWLLPPLSLEETAERYIRPALRHAFIRLCRGSAHEYLDRFGFESDLVKAMYAVTDAFSGLDAGYDTPGAGMNLLVHNMCRLPGSGGTWMIVSGGMGTVTQSLERVARRHGAEIRTRAPVASIRTDGGVVKGVVLQSGEEISASVVVSNADPFRTLGLLESSAVPKDFRQRIEAMAAPGTTLKVNLCLKGLPTFTCLPEDRGQFGPTIHLLPQEKDVLGALARAYADTKAGRLSEFPSIEWYFHTPIDPTLRDDQGHHNSALFVQWVPSQPAGSSWEKEESRYVQHLLSICDRFAPGTSDLVVETFALTPPRIESHFGITHGHIHHVDNKRGFTDRLPYETPVQGLYFCGAGCHPAGSVIGAAGHNAAGVVLKALER
>NC_014623.1|WP_148273336.1|3281054_3282281_-|DNA-polymerase-III-subunit-gamma/tau
MIVPMSYLVLARKWRPQTFDDMTGQEHIVRTIANAIKMDRVAHAYLFCGPRGVGKTTAARLLAKALNCEQGPTASPCGTCRACTEITSGTSVDVAEIDGASNNGVENVREIRENAKYLPQRDRHKIYIIDEVHMLSGAAFNALLKTLEEPPGHVKFIFATTEAHKLPDTILSRCQRHNFRRIPAARMLQRLKQICEAEGAGISDRSLSLVVRQSEGGMRDALSLLDQVLASCGAQPTDESVAEALGAIDRTVVQDFAEALVRKDARKVLERVEETFNRGLDLKRLAEELALQLRHLFVTKAVGEAPAELAESEQKALIALAQEADSAQLARLFDIVHGCVWDVSRAAQPRLALEMALLKAIQLSPSSSIPDLLAKVDRLAQGLTAGDGSTKSQSGASGGRSGPTNFRV
>NC_014623.1|WP_013375386.1|3280168_3280870_-|hypothetical-protein
MAPPAPAPAGATPLSRVTTPAPVVRVTNVRKPESVADSVDERLFPEEGSAEGCASGDCLPGEEPEPEAPPPPVAQGRDNPALPLAERWRAAVETVRGASARHGTSLAHGRLLWLRPGEVGVAYVPSAAFHRSIIGAPSGKAVVEKALAEHFGRPMKLAVEEASAEVAASTVSIAEQDSQARAAHTQSTEGKVRSHPAVRSVLKLLGGEIEHIQVIEPERPSASPAPEVPEDSA
>NC_014623.1|WP_013375385.1|3279756_3280074_-|YbaB/EbfC-family-nucleoid-associated-protein
MPGIDLNYFIRQANKLTEKIEQRKQELANEKVEASSGEGRVKVVVNGIQEVQSIHIDKAAIDPNDTGMLEDLITAAVNAALASSRQHMQKELAKISGGVKIPGIT
>NC_014623.1|WP_013375384.1|3279156_3279750_-|recombination-protein-RecR
MTPDPLNRLVAQLAKLPGIGEKTAQRLAFHILRAPSEYAVDLSQAIREVKEKVHLCTRCFSLTDTELCGFCRDSRRDERVLCVVETFADLMALERTREFKGRYHVLHGVLSPLEGIGPDQLRIRELLERLADSKVEEIILATNPDVEGEATSLYLMRLLKPLGLRVSRIAQGLPMGGDLEYADQATLAKALSARREL
>NC_014623.1|WP_013375383.1|3277407_3279150_+|serine/threonine-protein-kinase
MNESQTVLEPAIVAQPLRPYGNYVLVRKLAEGGMAEIFLAKLLGADGFERNVVIKRMLSHLSSMPDFVDMFRDEARLAARLSHPNIIQIHELGFIEGCYYICMEYLAGEDFSTTLRQAGRKRQYTPIPIVLRVLVDAARGLHYAHEFTNEMGQCLNIVHRDISPSNLYLTYQGQVKVLDFGIAKAESRLAQTRTGVVKGKYIYMAPEQARGDEVDRRSDVFSLGVSLYESLTNVRPFARENDLAILNALLKGDFAPPTTLRREVPKALEAVVLKAMAPRPEARYATAGEFADALERGLADQVPLATHAQLVEYLRGQFGDERFAEKTRIPALATLKAQAAATPPPPPRSSVTISVVSAQTFVEGAGGAQATREGASRGRGRGTRLVALGAAVGLLLLGAAFTTWRLSAAPVVTARIEPAPAPSPVSVPSPGTAPELPPAPEPPPAVAAAPVAEPPAVAVEAPPPEPEKVPASPAKASSKAAKARAVTLGLEDVQRVVSRASARIANCFERHKADLPADAGKVSVRLTIASSGRVKAQTQGPLASRSVGQCLEAQAERLRFPAHRDQEVNVVLPFDYRVAR
>NC_014623.1|WP_086016059.1|3275473_3277396_+|FecR-domain-containing-protein
MVGCDPEAPPPAPPAGTPAPPAPPAPAGAPDTLARLEALQGEVRWEQGGKTVPASEGPLVKGAALETGPDGSVTVRFEDGRTVEVGPNARFVLDEDASGVVLQVARGIVLSRVPVAAPGRPGPRVELRILTPYGFTRVSGQEASEVRVSVGPSEGHVEVRLGTIAFVDKDGGELQAQAGETVSVTAGRAELVARPAKVFELAPIQVTVRADSGRVEVRAQGSERWTVSKGAQPLSPGDGVRVRGGVALLGLEGSASTLALSSGGEMVLEKAGQQGTTDEARVDLRRGALSLRLAEGRDSRVVMPGLTVEAHAAAHVDVRRTSQGLDVASLAGDVVLLQGSNRQPLRAGEQASVAGTGPVKIVALERGPLVLPVETRIQVFHRGLEEVTFDWKEEGDAVVEVATDAEYQRLVLRGLVHQPFLRMPAPARGALYLRVRRPEGTEVVRGSASFAPERAPKELARVTNEVPEGLEKTTIYYQDKPPAVTFTYGSEAQAARYRVQVYRSGALGKPVAERTVSDTRASVEAGVLGEGSFLWSVTPLSQAGKALRGGRMNKLELVYDNSVPVLVVNSPRHGQQAGNRVRATGVAPMGARLSINGRPVTLDSKHRFNTWAEPVGAPPLLLFKMQRAGGPDVYLVRTLK
>NC_014623.1|WP_037584072.1|3292465_3293782_+|FAD-dependent-oxidoreductase
MDPTVILGAGLAGLSAAHFLKRPWRLIEKTDRVGGLIKTEVIEGCYFDPTGHWLHLRDPEIRELVNTRWLPGQMVSIQRKAAIFSRGVFTRFPYQVNTHGLPPEVVAENLVGYVEAIYGEKGRALREREPRNFEEFILRYMGEGFAKNFMVPYNQKLWTVHPRELSAAWVGRFVPRPSLKEVVDGALGVGSDALGYNASFLYPREGGIESLAQAMLRGLEGGEVSVRTEPTAIDWKARRVTLSDGRTLGYSELLSTLPLPYLVRLLAQGASGVPDEVLAAAGRLRATTVTYVCVGARGKNRQPWHWIYLPETEFTTYRIGSPSAVYEPLAPPETATFYVEYSHHGELSPAQCEQFAVKELVLSQMVHAPEDILFARAVEIPHAYVLYDDAYGPAKAEILRFLEHARILTAGRYGQWEYSSMEDAILGGRACAQVLNAR
>NC_014623.1|WP_002617574.1|3293874_3294585_+|glycosyltransferase-family-2-protein
MAPYLSVIIPVYNEASILASAAAELCQGLDARGWDYEVIFAENGSRDATPELLEKLCAQNPRLHWFHSERPNYGAALKAGITRAQGTYVVCDEIDLCDLTFYDAALPRLERGEADMVVGSKAAKGASDRRPMVRRVATRVHNKLLKVMLDFRGTDTHGLKAFRREALLPVIARCVVDMDVFASEFVIRAWREGLKVMEIPIQLHEKRQPSIHLFRRVPNVLKNVGKLVYVIRIRGT
>NC_014623.1|WP_002617567.1|3294598_3295540_+|polysaccharide-deacetylase-family-protein
MASRLASISVDLDSLHHYCRIHGLPETVLDARARGLVYAKAVPRFRELWGALGVPGTFFAIGEDLADAGAAEALRQAQAAGVEIANHSFSHDYALSRRAPESIHEDLARGEQAILAATGTRPVGFRAPGYTLNAALYAATAARGYRYGSSAFPAAPYYAAKATVMGALALAGRPSRSVLDSPRVLLAPREPYRPDPRQPYRRGTGTVVELPMTVTPGARFPFIGTFAATLPMSFIRAAYLACRGSALFNFELHAVDVLDATDGIPAELVRQQRDLQVPAARKMERLATLFRWLKADADTVTLREAAERLAPGL
>NC_014623.1|WP_002617578.1|3295635_3296490_+|acyltransferase-family-protein
MFEQLGDKVRKQLKGWTEQMAGQERKDRLQALARTENEYGVDPFGFNLDFSLAAVAPLLWLYRHYHRVETFGLENLPPGRVLLVSNHSGQLPMDGAMIGVALMMEADPPRAIRSMVEKWVPTLPYISAFFARVGQIVGTPENCRRLLAAGEAILVFPEGTRGISKLWPQRYQLQDFGLGFMRLALETDTPIVPVAVIGAEEQAPALMDLKPLARLLGFPSFPITPTGVPIPLPTKYRLYFGEPMRFTGRADDEDSELDKKVRTVRAAIQAMIHQGLKERRSIFW
>NC_014623.1|WP_002617568.1|3296521_3297445_+|SDR-family-oxidoreductase
MRPAIVVTGISGNLGRTLAKLLHKSERIIGIDRRPFVGRPKDVEMYQLDLRKKKAEDVFRKNEIRAVIHMGIMHDPRMSEEEHHSFNVVGTTRLLEYCAKYGVKKVVFLSSANVYGPSPDNSNFLTEDAPLMASSRFSGVRDLIEVDMLAHGFFWRHPDINTVILRPVHIVGPTIRNAPSNYLRLRHPWTLAGFDPMVQLIHMEDVARAMVEALRPEPKGVYNVVGPGEVPLSSVLRELGHVSIPVPHPIARPVLSMLFKYRLANFPPPELDHIQFLCNVDGSRWRKELGWKPHHSMRDTIRSVIGE
>NC_014623.1|WP_002620489.1|3301878_3302220_+|hypothetical-protein
MGGNAFLLSIIYLVTGIGVEVARRYYPTRFVQQLSLSLDSLPARALEFVGALEPLRAAYLEGRVSDAQVRLLFGSTTIVVIFILAFVVGILVGGLRSYVERRAIRKASERRPG
>NC_014623.1|WP_013375394.1|3302232_3304266_-|ATP-dependent-DNA-helicase-RecQ
MRRMLPEDLPHFVEAQEGLVRHFGLSEFRPGQAEVISSVLSKRNTLVVMPTGAGKSLCYQLPALLLPGLTLVVSPLIALMKDQVEQLTARSIPATFINSSLSDLERAERMRRLRAREYRLLYVAPERLRSTGFLDTLGEVGVDLLAVDEAHCISQWGHDFRPDYAQLGQIRKRLRPPRTMALTATATPEVRDDIIRVLLMKDTQVFAQGFDRPNLFLEVMSVSGDEEKRQGCAQLAAQGGSGIIYCATRKAAEGMHAALMGRGVNAFLYHAGMEDEARRRAQEDFMSSKEAVAVATNAFGMGIDKPDIRFVAHANIPRAVEAYYQEIGRAGRDGQPATAVLLFNHADVYTQERLIEGNHPSDVVLGDIWNVLRHVPEFDKGVGVLAGMVGASEFEVSAALRIFEREGKVERGSRGEGEYGLTLTDKAATAHPHAADAQRLLQSLLATFPSGRSVTTELSVLSRRTGLPLDEVRHALGLLEKAGVVTVRRPFSGRTIRALEAVSFQELGVDLSRLREQERRSLLLLKRMTDYAYTKRCRRAFILGYFGQSDVEANCGHCDVCTGARMARLAPLSRQAATTGRPENYSELAATELRRWRKALAKDLEIPPFIIFNDATLLGLAAALPTDRSTFLAVKGTGESRWERFGTKVVEICLMARAAGHEPVAVTEAARGRRRRE
>NC_014623.1|WP_148273592.1|3304268_3304574_-|DUF3006-domain-containing-protein
MVGSGDAGRCSGQAWQVEVVEDTRVQVVELDTGRARTVDRSTLPREAREGDVVVDGRLDPELRARMAQEVAEVRARRAVPVPRGLDLEGSPAPPLTARKEQ
>NC_014623.1|WP_041791853.1|3304582_3305350_-|DNA-repair-protein-RadC
MGRAAAMRTVGEAASAGEGSVRARPPGLDEVRERLFQLGASALTDPELLSVLLGPGTRTHHLAEQLVSGLGGLKALIHMDPLQLCTRPWLGPVRTAQVLAALELGRRAQRATERRPRLRTPKEIHLYLSPTLNALRREVFHVLCFNPRNVLLGNVRVAEGTMNTCPVDPREVYAAALSLRATALVFAHNHPSGDPEPSAQDVRLTAQLAEAGQLLGIKVLDHLVLGDGTYVSLLERGLLPGTEGRNAWSAVGGPG
>NC_014623.1|WP_002615550.1|3305468_3306332_-|NAD-dependent-protein-deacetylase
MSALPVPPSPTSVPSNVEALVRLMRGRRAVVLTGAGCSTESGIPDYRGPGTRARARNPIQHMEFLHRAEVRTRYWARSLLGWPRFSSAQPNAAHHALATLERAGHVQGLITQNVDRLHHAAGSTRVIELHGALAEVRCLTCHTREARASLQERLLALNPGFLEHVVEFRPDGDAELSTETLHAFRTADCLHCDGPLKPDVVFFGDNVPRPTVDAAFALLEEGDVLLVVGSSLAIFSGYRFVTRAAERGMPIALVNIGECRGAALANVVLEARAGEVLPLLAERLAQG

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Crispr_ID: NC_014623_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014623_6

8408547-8408625

Orphan

Consensus_repeat	Method
GGCTGTGTCTGCGCAGAGTGGGGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014623_6

>merge|NC_014623|6|8408547-8408625|CRISPRCasFinder
GGCTGTGTCTGCGCAGAGTGGGGGCTGTGACGACCCCTTTGGCTCCTGCGGGGAGGCTGTGTCTGCGCAGAGTGGGGGC

>NC_014623|6|6|8408547-8408625|CRISPRCasFinder
GGCTGTGTCTGCGCAGAGTGGGGGC	TGTGACGACCCCTTTGGCTCCTGCGGGGA
GGCTGTGTCTGCGCAGAGTGGGGGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_014623.1\|WP_037583529.1\|8410363_8411383_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_014623.1\|WP_013377532.1\|8398888_8399656_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|378924
NC_014623.1\|WP_002614230.1\|8407705_8408068_+\|NADPH-dependent-7-cyano-7-deazaguanine-reductase-QueF	unknown	unknown	gnl\|CDD\|213775
NC_014623.1\|WP_013377535.1\|8402543_8404532_+\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_014623.1\|WP_002614249.1\|8404544_8405564_+\|poly(3-hydroxybutyrate)-depolymerase	unknown	unknown	gnl\|CDD\|226040
NC_014623.1\|WP_002609354.1\|8418154_8419147_+\|cyclase-family-protein	unknown	unknown	gnl\|CDD\|377240
NC_014623.1\|WP_037583524.1\|8401012_8402293_-\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|235963
NC_014623.1\|WP_002614257.1\|8397148_8397583_+\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|176874
NC_014623.1\|WP_037582882.1\|8416949_8418065_+\|DGQHR-domain-containing-protein	unknown	unknown	gnl\|CDD\|274476
NC_014623.1\|WP_002620211.1\|8413174_8413645_-\|hypothetical-protein	unknown	unknown	unknown
NC_014623.1\|WP_013377540.1\|8414608_8415565_+\|hypothetical-protein	unknown	unknown	unknown
NC_014623.1\|WP_002620209.1\|8413638_8414319_+\|FMN-binding-negative-transcriptional-regulator	unknown	unknown	gnl\|CDD\|377290
NC_014623.1\|WP_002614219.1\|8405598_8407494_-\|GAF-domain-containing-protein	unknown	unknown	gnl\|CDD\|223715
NC_014623.1\|WP_013377543.1\|8419159_8419549_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227889
NC_014623.1\|WP_002614229.1\|8400475_8401000_-\|peroxiredoxin	unknown	unknown	gnl\|CDD\|239315
NC_014623.1\|WP_013377538.1\|8411683_8413165_+\|adenylate/guanylate-cyclase-domain-containing-protein	unknown	unknown	gnl\|CDD\|143636
NC_014623.1\|WP_013377541.1\|8415657_8416965_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223420
NC_014623.1\|WP_013377533.1\|8399905_8400433_+\|hypothetical-protein	unknown	unknown	unknown
NC_014623.1\|WP_037583528.1\|8409452_8410349_-\|tRNA-pseudouridine(55)-synthase-TruB	unknown	unknown	gnl\|CDD\|211339
NC_014623.1\|WP_002614234.1\|8397636_8398866_+\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035

Protein	Function_ID	Function_description	E-value
NC_014623.1\|WP_037583529.1\|8410363_8411383_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.40523e-102
NC_014623.1\|WP_013377532.1\|8398888_8399656_-\|alpha/beta-hydrolase	gnl\|CDD\|378924	pfam12697, Abhydrolase_6, Alpha/beta hydrolase family. This family contains alpha/beta hydrolase enzymes of diverse specificity.	4.95404e-11
NC_014623.1\|WP_002614230.1\|8407705_8408068_+\|NADPH-dependent-7-cyano-7-deazaguanine-reductase-QueF	gnl\|CDD\|213775	TIGR03139, QueF-II, 7-cyano-7-deazaguanine reductase. This enzyme catalyzes the 4-electron reduction of the cyano group of 7-cyano-7-deazaguanine (proQ1) to an amine. Although related to a large family of GTP cyclohydrolases (pfam01227), the relationship is structural and not germane to the catalytic mechanism. This mode represents the shorter, gram-positive version of the enzyme as found in B. subtilis. The enzymatic step represents the first point at which the biosynthesis of queuosine in bacteria and eukaryotes is distinguished from the biosynthesis of archaeosine in archaea.	3.5951e-67
NC_014623.1\|WP_013377535.1\|8402543_8404532_+\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	4.46475e-80
NC_014623.1\|WP_002614249.1\|8404544_8405564_+\|poly(3-hydroxybutyrate)-depolymerase	gnl\|CDD\|226040	COG3509, LpqC, Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism].	9.89325e-64
NC_014623.1\|WP_037583524.1\|8401012_8402293_-\|amidohydrolase-family-protein	gnl\|CDD\|235963	PRK07203, PRK07203, putative aminohydrolase SsnA.	8.77386e-113
NC_014623.1\|WP_002614257.1\|8397148_8397583_+\|SRPBCC-family-protein	gnl\|CDD\|176874	cd08865, SRPBCC_10, Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins. Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	1.43437e-48
NC_014623.1\|WP_013377541.1\|8415657_8416965_+\|hypothetical-protein	gnl\|CDD\|223420	COG0343, Tgt, Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis].	0.000197354
NC_014623.1\|WP_002609354.1\|8418154_8419147_+\|cyclase-family-protein	gnl\|CDD\|377240	pfam04199, Cyclase, Putative cyclase. Proteins in this family are thought to be cyclase enzymes. They are found in proteins involved in antibiotic synthesis. However they are also found in organisms that do not make antibiotics pointing to a wider role for these proteins. The proteins contain a conserved motif HXGTHXDXPXH that is likely to form part of the active site.	1.96062e-18
NC_014623.1\|WP_002614219.1\|8405598_8407494_-\|GAF-domain-containing-protein	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.23497e-52
NC_014623.1\|WP_013377543.1\|8419159_8419549_-\|hypothetical-protein	gnl\|CDD\|227889	COG5602, SIN3, Histone deacetylase complex, SIN3 component [Chromatin structure and dynamics].	0.00281219
NC_014623.1\|WP_002614229.1\|8400475_8401000_-\|peroxiredoxin	gnl\|CDD\|239315	cd03017, PRX_BCP, Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing and detoxifying hydroperoxides. The protein was named BCP based on its electrophoretic mobility before its function was known. BCP shows substrate selectivity toward fatty acid hydroperoxides rather than hydrogen peroxide or alkyl hydroperoxides. BCP contains the peroxidatic cysteine but appears not to possess a resolving cysteine (some sequences, not all, contain a second cysteine but its role is still unknown). Unlike other PRXs, BCP exists as a monomer. The plant homolog of BCP is PRX Q, which is expressed only in leaves and is cellularly localized in the chloroplasts and the guard cells of stomata. Also included in this subfamily is the fungal nuclear protein, Dot5p (for disrupter of telomere silencing protein 5), which functions as an alkyl-hydroperoxide reductase during post-diauxic growth.	6.05794e-37
NC_014623.1\|WP_013377538.1\|8411683_8413165_+\|adenylate/guanylate-cyclase-domain-containing-protein	gnl\|CDD\|143636	cd07302, CHD, cyclase homology domain. Catalytic domains of the mononucleotidyl cyclases (MNC's), also called cyclase homology domains (CHDs), are part of the class III nucleotidyl cyclases. This class includes eukaryotic and prokaryotic adenylate cyclases (AC's) and guanylate cyclases (GC's). They seem to share a common catalytic mechanism in their requirement for two magnesium ions to bind the polyphosphate moiety of the nucleotide.	3.20946e-58
NC_014623.1\|WP_037582882.1\|8416949_8418065_+\|DGQHR-domain-containing-protein	gnl\|CDD\|274476	TIGR03187, hypothetical_protein, DGQHR domain. This highly divergent, uncharacterized domain has several absolutely conserved residues, including a QR pair and FxxxN motif. Its most striking feature, however, is a near invariant pentapeptide motif DGQHR. Several different subfamilies occur specifically as a part of DNA phosphorothioation systems, previously called DND (DNA instability during electrophoresis), while others (e.g. CPS_2936) occur in other contexts suggestive of lateral gene transfer (sporadic distribution of helicase-containing cassettes). The region described by this model is about 280 amino acids in length; additional sequences show local sequence similarity.	2.65509e-68
NC_014623.1\|WP_002620209.1\|8413638_8414319_+\|FMN-binding-negative-transcriptional-regulator	gnl\|CDD\|377290	pfam04299, FMN_bind_2, Putative FMN-binding domain. In Bacillus subtilis, family member PAI 2/ORF-2 was found to be essential for growth. The SUPERFAMILY database finds that this domain is related to FMN-binding domains, suggesting this protein is also FMN-binding.	6.98019e-80
NC_014623.1\|WP_037583528.1\|8409452_8410349_-\|tRNA-pseudouridine(55)-synthase-TruB	gnl\|CDD\|211339	cd02573, PseudoU_synth_EcTruB, Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). E. coli TruB and M. tuberculosis TruB make psi55 in the T loop of tRNAs. Psi55 is nearly universally conserved. E. coli TruB is not inhibited by RNA containing 5-fluorouridine.	8.96966e-65
NC_014623.1\|WP_002614234.1\|8397636_8398866_+\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	1.02527e-84

>NC_014623.1|WP_002614230.1|8407705_8408068_+|NADPH-dependent-7-cyano-7-deazaguanine-reductase-QueF
MPSEPSKDLQTFPNPASERDYEIAFDVPEFTCLCPMTGQPDFAHFKIRYVPDELCVELKSLKFYMWSYRNEGAFHEKVTNTIADDIIRAIKPRKLTVVGDFFVRGGIGTVVTVTHEKKKG
>NC_014623.1|WP_002614219.1|8405598_8407494_-|GAF-domain-containing-protein
MVPSDFENVLHLLPQAMLRVGPELQVQWLEADFARKVGLSLTVGRGLLEGLEYSRSRDALARAVRTGRSYAGHLITSAMRQVRVQVQPAGEAEPPGAWLIFDPSGMDDEEAFSQVVQQVARAVGETLDVDSVCSAAVLALVRCAQVRRAEVFLCEEGTQGALRRAAVSDLADRDSPEDTFDPAADPFQHALATRRAQIGVQRGYGDSMGSIFAAVPLCAPKRTVGLLLLYKEQGASFSVRELDLWMAAAGQLAVAVENARLLREAQAALRVREEFMSIASHELKTPLTPLKLSLYTMERRIATGQPVELASVLKSKRQVDRLAGLVDDLLDASRLELGKLAMHAAPLELGQLVAEVVDHFRHAFERPFSVSVSRSRVWVQGDRDRLEQVLVNLLENAHKYSPAGAPITVEVEEGGDEARIHVKDHGIGIPGADQAQVFQRFYRARNVSHRNFGGLGLGLFISHSICKMHGGNLTLSSAEGQGSTFSVSLPRMSAREVGRLPRRVLLLDEDRLQEDEAARVLRAEGFEVLTVRDGNEALRQEAHLPVDLILLSASASQKEVGVFLETFATLPRARPVPILLAGARLPTWAQEGTVLCARPYRQDELVARVRNTLALTPDPGWPVAEEVMVRM
>NC_014623.1|WP_002614249.1|8404544_8405564_+|poly(3-hydroxybutyrate)-depolymerase
MTPPALLGFLGAVWLLASAPACSSDSSDAPPGGAPDGGFPPIVDRTSCTGLTVRPGDSEWTLEHEGRSRVYTLHVPPGYDAAKPTPTVIAFHGFGSTELEQEGLSRMSEVADEEGFLAIYPRGLNNPEVERTPDGGFADSRSWNAGGCCGSAQLARVDDVAFVEALFADLDTKVCVDTRRTYATGLSNGAFFSYRLACERAERFAAIAPVAGMENVPECEPHRPVPVMHFHGTADTTISYHGGTIPFGRAYPSAPATVALWAERNGCSGPQTQTYRRGDSTCVTHTGCQPEGATATLCTVEGGGHTWPGGLVPPDLGYTTQDLDATREMWRFFKAHPRP
>NC_014623.1|WP_013377535.1|8402543_8404532_+|protein-kinase
MGRYRLSARIATGGMAEVYLGRRIEEDGRRGPSVAVKRLLPHLTSDRRVVQMFLNEARITAQIHHPNVVTILETGMDGGEPFIALELLEGRSFAELRQEAAERGRRVPLGVTLRTLVDACRGLDAAHRAVDEAGRPLRIVHRDFTPDNIHVGANGCVKVIDFGIAKADALGSGTEPGTLKGKFFYMSPEMITGQRVDHRADIFAAGVMLYEQLCGRRPFTGLKPEEVLARITEGRPKPPTAFDPSVPDALEHICLTALHRAPESRFETLQVFIDAIESVGGSAEVASSEAVAAYVESLFPKDSDPKRLTLQRARSADPSDSGVSAPSAASAPSRAPRADSQPPRREPPPRKRRQWALLALAGLALLGLGAGGTYLMLRPTVPPAERLAQAETAPAPPQRLAFLEGIEKDPRATAQELARAGELLMELGAHEAVLSLSETFTQRFPQDLEAHLLEARAATALLMGKRAERSIEEASSLAPKDVRPLLALADLRERQGDVPGALGALAKAYEKRPREARVAPRYGLLLSQSGRLDEAAEVLGAWIREHNDARPLAELAFVRYRQARMEDAAALLKRALRKAPRLAVAHYYLGAVLFQKGDTAGAERAYRQADQLDPEDPRALSARCQLHARTGDANAVAEAKQLIASRFPAQATALAAECSAGH
>NC_014623.1|WP_037583524.1|8401012_8402293_-|amidohydrolase-family-protein
MGTVLKGGHVVELEPALVERVDLRIEGERIVERAPDIAPRPDDEVVALSGKLIFPGLVSAHHRLHASLARGLAEPRAGNYQEALENGRWRYEAALDGDAVQVAACVGGLEALQCGTTTLFDFHSSPKAIAGSLVRVARGLHEVGVRGVLSYAVTDRKGALGREEGLEETVGFARKAKGRFRGQVGAASLFTVGPEALAGIQEALAATGAGLHVPVAEDPLDEKLSVERHGAPPVTRLLEAGLLSPKSQLAHVGHLAWAELAQLLATGTWVVHTPRSNQQLEVGYAPALKFGARATLGTDGMAADVFAEAQAAYLRSREAGQPIDVLRYLANGHRLASQSFDFPVGPLREGAAADLLLLDYLPPTPLNAGNLAWHVAYGLGSRHVEAVMVEGTWRIWARRPLSVSPSVVADQAREAATAVWARMSQG
>NC_014623.1|WP_002614229.1|8400475_8401000_-|peroxiredoxin
MLLPLLMTGFFAAATPQAGDTAPDFTVTDTDGKKYTLSEQVKEGPVIVAFFPKAFTPGCTNELTAYRDRYADIEKLKGQVLAVSMDDAETLKKFKDSLKAPFAFIPDPDGAVVKQFDVKTPVMSYAQRYTFVVGEGRKILKVESGKDAIDPSSAIAACPLRKQDAKPDTKAKPH
>NC_014623.1|WP_013377533.1|8399905_8400433_+|hypothetical-protein
MNATRSPSLVLAAVAAVLLTSCHAGHNKAVPPANAGEAAGAAASGACQDAPTVELPSLFASPADAASRPEAGAVVAMEGTPLAGLVCTLMACDAKCCNNACGSTEGCPFTLATEQGNLCLSHQDFACGGTDCSPWCRPFNLSEKRRYRFVGTLSYQAGQEPPGATLHVQKFCPID
>NC_014623.1|WP_013377532.1|8398888_8399656_-|alpha/beta-hydrolase
MRFNVAVTLVLALLLSSTGALAGSKRSTYILVHGAFHGGWAWQALAEELRQDKATVYTPTLTGLGERAHLARPDVSLETHVQDIVSLILFEDLRDVILVGHSYAGMVITGVAAALPDRIDRLVYFDAAIPEPGQSFFATVGFPDAFPADMWLLPSFSPQDFGVTRPSDVAFVGARLRPQPLATFQEPIAFDWKTLSKIPKAYIHCKGEWFQRDIFLGFRAKAVARGWKLEDLHASHDAMVTDTKKAYKALQDVVD
>NC_014623.1|WP_002614234.1|8397636_8398866_+|cytochrome-P450
MPLSQTFHPFAPPLRDNPHPIFEEARKEEPVFFSEILKCWVVTRYEDVYAVLQDSRRFSSAGNLAVHKESLCPAAKSLLIENQYTDPPLVNEDAPVHTRRRPVYKKLFSQEAIRSLEPRIRDITKELVDGFAHQGHADIVSQLAYPLPMRVVLSWMDIPQEMMETIKRWGDAWVLLLFAELTPEHQMECAHMVVKLQRYIADLLAERLDQKRTDAMTQLATQLLTLEKLSIEELAGMVSGTVVAGNATLTSMVGLTTRVFLQQPNLWQRLREQPERISQAIDEALRLESPFWGLRRVTTEPVEVGGVKLPAGARVLVAFISANRDVERFPQSEVFDLDRPNASQHMSFGKGVHVCVGSGLAKQEVQAAMEVLLQRLPDARLVPGQELTFVPGLLRQHERLLVEWSPQRV
>NC_014623.1|WP_002614257.1|8397148_8397583_+|SRPBCC-family-protein
MRVSHSVLIHRPVEQVFAYVTDLRNEVRWQPEIKEVRITSPGPLGKGSTFIEVRRTFGRNLVWHFEIEDYEAPFRLCIRSTSGTMPYTGCRLFEAVPEGTRVTESGELTTPLMVRWMDGLFARLSQRPLTAAYGNLKALLEQDS
>NC_014623.1|WP_037583528.1|8409452_8410349_-|tRNA-pseudouridine(55)-synthase-TruB
MAPGIHLVHKPLGETSFSSVRAAMAELEAARPGKRVPVCHGGTLDPFAEGLLLLLVGQATRLMDLLHAVPKHYVAQVIWGTETDTGDLLGRVVHAGDPSALTPGALEAALAGFRGWQDQVPPATSAKKLGGEPAYRKAHRGEEVVLPPSRVYLHEARWRSHELPRSSQLELVCRGGFYVRSLARELGRILGCGAHLARLHRTAIGPWEDPGPGRRMGLHGRQVLPWSALRELSDAEVGELRRERPIALGRLLPPDWRLPPGFPDPEAPVRGFHLGRLVALLREQEGAFRMQMELRGGL
>NC_014623.1|WP_037583529.1|8410363_8411383_-|serine/threonine-protein-kinase
MAQVYRGLHETIQREAAIKELLPEGQRDKESLSRFHREALALAAFRHQNIVTLYDMVEKNDSLFMVLEFVDGPTLQELIKEGPLPADVAAVICARIASALDHAHFRHIIHRDLKPANVMLTKAGEVKLMDFGIAKDVDLVALTQQGVAVGTPAYMSPEQVTGAKLDPRTDIFSLGVLLYETLTGTRPFQGRTAGEVFAKIRDGLYKPLHKVAPEVPKPLVNIVRRALEVKPENRYPDAAAMRRELDLFLAREIEVSHPALLVAFLRHREKLTESEALAHLTQAELGVLDSYAAGRRKRPAGGKLKWVVAALLALATATGTGIYLTQDQWAPPVEKKMKR
>NC_014623.1|WP_013377538.1|8411683_8413165_+|adenylate/guanylate-cyclase-domain-containing-protein
MTPPSDVRLSVGLRLLLHSGSVLVGLFTFVYARLVCTFICGLPTPVLARTVAILTVLHISLRELLLQRVPLSGKSASPARRAWLLSVLSWGVTGLAASLLHKAQYPAFPLFSHVKFAMGYGLLGGALLGQVEYLLFERALPPAPSVSRAEQLRERLGRRLIEGYVIFTTVPAAVLLLTLLRFIWELHGESHYVVEAAMMSLGFTGIALGAAVAYGRSVRRDTERLLEAVRRVGSGDFQPGASTSRPDELFLVAEGINEMAGGLQLRERIREAFGRFVSPQVASEFIEKYARHGKTAVMGGERKDVVVLFSDLRDFTHLSESLAPEVLIEVLNGYFQEMVGAIQQHGGMVDKFIGDAVLAVFGLTEGEANPARAAVAAGLEMQRRLEAYNARLAERGIQLRSGVGIHAGEAVAGYLGSTDRMEFTVIGHTVNVASRIEGQAREPRPPLLFSEEVARRFGDAFGVKDVGSVPLKGVAHEVRLLTVTGEGGSIQAA
>NC_014623.1|WP_002620211.1|8413174_8413645_-|hypothetical-protein
MSFASPVRLGVVLALSLVGCTQPQRPYTFKAPQGPESPIDTLVRALISAGHPPESVEPELGILHTRWESTGVCYTPTQKEGSLMRRFTTTVAPMASAGNTITVSMDAQCCEIRGENRHGDSWQGPCTVVSEILEMHQREVNSLGATLQRAMDDAAK
>NC_014623.1|WP_002620209.1|8413638_8414319_+|FMN-binding-negative-transcriptional-regulator
MTRNLSKPGRKTPCYHNAMYTPPHYKEERPEVLQALIHQHSFGLLISSGPHGVEATHVPFLLEVEGPGPGRLLAHLSRANPQWRHLEEAGEVLAIFSGPHAYISASWYTERTDVPTWNYVAVHASGRARVMEGDRLRSLLDRMSRRYEQTSAAPWSLEDVPEASLQAMTKGIVGIEIDITRLQGTQKLSQNRSAEDQQRVIHELKARGSQDDLALAALMEHPSRPR
>NC_014623.1|WP_013377540.1|8414608_8415565_+|hypothetical-protein
MPADLHIIASCTDRKRMTVPDTLRLRSVTASGIEARARQWWARLEQPAAPPVRALELYAGDHWRIIRELPAMATAAGFSPKLWIASAGYGLIPANAVIQPYSATFAPGKPDSVTMDHAGVPSRAQHQRWWDAMARMARAPSSTPRQVQQLAESGRNPILLVVASPSYVAALEQDLVLAAQALRHPERLIIISAPSRIARGTLAPHWVPSSAHLQAQLGGARLSLHARVARKALQRARHGILDARELRGYYGRLIQCSHPLVRYERTPMTDDDVRAFIARALRVEPLSCSATLRKLRDSGHACEQQRFKRIFLELRECT
>NC_014623.1|WP_013377541.1|8415657_8416965_+|hypothetical-protein
MKFFLPDSQDLVDPSFDFENEQRSKDRRRQRHDLYAHEVFSQPAFDGFLVSKGMVDGFGALGSRYTLSQRLRLSQMGAPEFFRVERAPHPLQIMGDCGAFTYVKEQKPPYSVDDVIDFYATSRFDYGVSLDHVILDFIPEADAPGAGPRAVPAAIRHRQELTLQYATEFLHQHRLGRHAFKPLGVAQGWSPQSYATSVKRLQKMGYDYIALGGMVPLKTQDILRCLQAIQDQRAHGTRLHLLGVTRTEHLEEFYRLGVASFDSTSPLRQAFKDAHDNYYFNGQTYTAIRIPQVEGNTRLQQRIASGQISQNQARKLETACLQAMRLFDAGRRSLSKVIEVLLEYEDLYAHDVKRSHAKDYERTLTDAPWRQCACDICKHLKYHVIIFRGAERNRRRGFHNIWSLYHHMRGSGTGIPEFTVGQHAAGLKERACRTN
>NC_014623.1|WP_037582882.1|8416949_8418065_+|DGQHR-domain-containing-protein
MPDELRLPALEVHQSKGRKLYSFAVDGKLLQDFVTVSRVRRDDEQELSGYQRPEALAHIQEIRAYLEAPSPMIPNSIVLAFDSRVRFEPDKGKTAFPYVRTGTVVIPLAKDISDSDKPGFVVDGQQRLAAIRDADISRFPIFVTAFITNDVRQQTEQFILVNSTKPLPKGLIYELLPSTDAQLPSPLHRRKLPALLMERLNLDADSPLAGRIRTTTNPTGTIKDNSILKMIENSLSDGVLFHFLRPQTALGADVAPMLEILHHFWAAVARVFHAAWGLPPKQSRLMHGAGIISLGHVMDAISYRLRNVSIPTEAQYIEELMPLKAITHWTGGSWNFGNGERRKWNNLQNTPGDIELLSKYLCAPYQKQASK
>NC_014623.1|WP_002609354.1|8418154_8419147_+|cyclase-family-protein
MTLLKCFLLTGALLGTSPAAAQNSAPAPSFKTAQDVEAWKEKNRNWNRWGPEDQLGAVNLITPAKRKEAARLVREGVSISLAHPLETQKAADVSSPLGHKMLFTGESPESLYSADALSLEFHGFTHTHLDALCHVFDHGKMYNGYEQKLVTANGCAKLAVTTLKDGILTRGVLIDIPALQGVPYLEPGTPIHAKDLEAWEKKTKVRVSSGDAVIVRTGRWARRAAVGPWDVSQHSAGLHASTADWFKKRGVALVATDTGLDVLPSGVENDPFPTHVMLINALGISVLDNADTEALSKAIAERKRYDFLLSIAPLIVEGGTGSPVNPIAVF
>NC_014623.1|WP_013377543.1|8419159_8419549_-|hypothetical-protein
MLGSLVFAAPALFDEQSREPYPVGVGSSPMPGSSVTRPQGPLASRPGGTAARIGPFSVGLEHQLLQSLPVGGGPAVRKPSLVSVEARVSEEGTTQVPFLLPYACASQVKVTGPGVKGSKTLDTSFPCAE

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Crispr_ID: NC_014623_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014623_7

9278841-9278936

Orphan

Consensus_repeat	Method
GAGGGGACTGTGTCTGCGCAGAGTGGGGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014623_7

>merge|NC_014623|7|9278841-9278936|CRISPRCasFinder
GAGGGGACTGTGTCTGCGCAGAGTGGGGGCTGTGACGACCCCTTTGGCTCCTGCGGGGAGGGTGAGTGAGGGGCTGTGTCTGCGCAGAGTGGGGGC

>NC_014623|7|7|9278841-9278936|CRISPRCasFinder
GAGGGGACTGTGTCTGCGCAGAGTGGGGGC	TGTGACGACCCCTTTGGCTCCTGCGGGGAGGGTGAG
TGAGGGGCTGTGTCTGCGCAGAGTGGGGGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_014623.1\|WP_013377913.1\|9284762_9285281_+\|hypothetical-protein	unknown	unknown	unknown
NC_014623.1\|WP_002614816.1\|9278220_9278412_-\|hypothetical-protein	unknown	unknown	unknown
NC_014623.1\|WP_002614827.1\|9277380_9278208_-\|hypothetical-protein	unknown	unknown	unknown
NC_014623.1\|WP_002614822.1\|9267736_9267994_-\|hypothetical-protein	unknown	unknown	unknown
NC_014623.1\|WP_002614818.1\|9287145_9289659_+\|sodium-translocating-pyrophosphatase	unknown	unknown	gnl\|CDD\|234827
NC_014623.1\|WP_187323663.1\|9267451_9267712_-\|hypothetical-protein	unknown	unknown	unknown
NC_014623.1\|WP_013377909.1\|9270759_9277188_-\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|236848
NC_014623.1\|WP_002614815.1\|9290056_9290602_-\|hypothetical-protein	unknown	unknown	unknown
NC_014623.1\|WP_002614821.1\|9289739_9290060_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225893
NC_014623.1\|WP_002614829.1\|9291118_9291457_-\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132914
NC_014623.1\|WP_002614842.1\|9285559_9286942_+\|hypothetical-protein	unknown	unknown	unknown
NC_014623.1\|WP_002614814.1\|9290843_9291047_+\|cold-shock-protein	unknown	unknown	gnl\|CDD\|224197
NC_014623.1\|WP_013377906.1\|9268470_9269385_-\|response-regulator	unknown	unknown	gnl\|CDD\|381093
NC_014623.1\|WP_002614833.1\|9283778_9284645_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|367148
NC_014623.1\|WP_081465968.1\|9281850_9283659_-\|DUF5011-domain-containing-protein	unknown	unknown	gnl\|CDD\|374521
NC_014623.1\|WP_013377908.1\|9269929_9270763_-\|chemotaxis-protein-CheR	unknown	unknown	gnl\|CDD\|224271
NC_014623.1\|WP_013377907.1\|9269390_9269933_-\|chemotaxis-protein-B	unknown	unknown	gnl\|CDD\|319752
NC_014623.1\|WP_002614825.1\|9280497_9281841_+\|short-chain-fatty-acid-transporter	unknown	unknown	gnl\|CDD\|224942
NC_014623.1\|WP_013377904.1\|9264776_9267281_-\|response-regulator	unknown	unknown	gnl\|CDD\|223715
NC_014623.1\|WP_002614820.1\|9267986_9268391_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_014623.1\|WP_002614818.1\|9287145_9289659_+\|sodium-translocating-pyrophosphatase	gnl\|CDD\|234827	PRK00733, hppA, membrane-bound proton-translocating pyrophosphatase; Validated.	0
NC_014623.1\|WP_013377909.1\|9270759_9277188_-\|HAMP-domain-containing-protein	gnl\|CDD\|236848	PRK11107, PRK11107, hybrid sensory histidine kinase BarA; Provisional.	5.2527e-60
NC_014623.1\|WP_002614821.1\|9289739_9290060_-\|hypothetical-protein	gnl\|CDD\|225893	COG3357, COG3357, Predicted transcriptional regulator containing an HTH domain fused to a Zn-ribbon [Transcription].	2.64212e-15
NC_014623.1\|WP_002614829.1\|9291118_9291457_-\|STAS-domain-containing-protein	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	3.07164e-23
NC_014623.1\|WP_002614814.1\|9290843_9291047_+\|cold-shock-protein	gnl\|CDD\|224197	COG1278, CspC, Cold shock proteins [Transcription].	1.3953e-35
NC_014623.1\|WP_013377906.1\|9268470_9269385_-\|response-regulator	gnl\|CDD\|381093	cd17538, REC_D1_PleD-like, first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains. PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	1.92684e-32
NC_014623.1\|WP_002614833.1\|9283778_9284645_-\|glycosyltransferase	gnl\|CDD\|367148	pfam02709, Glyco_transf_7C, N-terminal domain of galactosyltransferase. This is the N-terminal domain of a family of galactosyltransferases from a wide range of Metazoa with three related galactosyltransferases activities, all three of which are possessed by one sequence in some cases. EC:2.4.1.90, N-acetyllactosamine synthase; EC:2.4.1.38, Beta-N-acetylglucosaminyl-glycopeptide beta-1,4- galactosyltransferase; and EC:2.4.1.22 Lactose synthase. Note that N-acetyllactosamine synthase is a component of Lactose synthase along with alpha-lactalbumin, in the absence of alpha-lactalbumin EC:2.4.1.90 is the catalyzed reaction.	9.77503e-10
NC_014623.1\|WP_013377907.1\|9269390_9269933_-\|chemotaxis-protein-B	gnl\|CDD\|319752	cd16433, CheB, Chemotaxis response regulator protein-glutamate methylesterase, CheB. This family contains the methylesterase CheB (EC 3.1.1.61; also known as CheB methylesterase, chemotaxis-specific methylesterase, methyl-accepting chemotaxis protein methyl-esterase, or protein methyl-esterase) domain, a phosphorylation-activated response regulator involved in reversible modification of bacterial chemotaxis receptors. Signaling output of the chemotaxis receptors is modulated by CheB and methyltransferase CheR by controlling the level of receptor methylation. cheR and cheB have a strong preference to occur in the same operon, and a subgroup contains multidomain proteins with CheB-CheR fusions. Reversible methylation of transmembrane chemoreceptors plays an important role in ligand-dependent signaling and cellular adaptation in bacterial chemotaxis. Phosphorylated CheB catalyzes deamidation of specific glutamine residues in the cytoplasmic region of the chemoreceptors and demethylation of specific methyl glutamate residues introduced into the chemoreceptors by CheR.	2.4088e-43
NC_014623.1\|WP_013377908.1\|9269929_9270763_-\|chemotaxis-protein-CheR	gnl\|CDD\|224271	COG1352, CheR, Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms].	5.69446e-41
NC_014623.1\|WP_081465968.1\|9281850_9283659_-\|DUF5011-domain-containing-protein	gnl\|CDD\|374521	pfam16403, DUF5011, Domain of unknown function (DUF5011). This small family of proteins is functionally uncharacterized. This family is found in Bacteroides, Prevotella, and Parabateroides. Proteins in this family are around 230 amino acids in length.	5.52572e-20
NC_014623.1\|WP_002614825.1\|9280497_9281841_+\|short-chain-fatty-acid-transporter	gnl\|CDD\|224942	COG2031, AtoE, Short chain fatty acids transporter [Lipid metabolism].	4.59267e-134
NC_014623.1\|WP_013377904.1\|9264776_9267281_-\|response-regulator	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	3.64709e-53

>NC_014623.1|WP_002614816.1|9278220_9278412_-|hypothetical-protein
MNATHQQVLNIHVQDLGFAPLLPVVVLLKRCALLDFLLHADDTGRRFWRRPKRVTLARQLQTR
>NC_014623.1|WP_002614827.1|9277380_9278208_-|hypothetical-protein
MFHLLKLGPVPLSQAQGSTNVYLRISASGEFASPVFEQDDAVGVQALLLGVEASEVCCEPALADVAQSLGLRVEPPPEQALTARAAIATFMAWEQRGVAALGADKALLFVQAATEFWEAQPWTHWDDSQPFAITLSGAHSHTYEGSVFGGGDEGGEGIALYEQSGALQVLMELQGQGKGRAATALPAIAVTLDHRPSYAVEALAAAHRAPRLPLPLKTGPSGLSVPSPMEAVVLVATLRAMARLTPSHREVLSTLVAGSEQLAVRVIAPAPRIRN
>NC_014623.1|WP_013377909.1|9270759_9277188_-|HAMP-domain-containing-protein
MRTQKNPVRKVSAKVVEPASDSLDTRQLLRVLAAVQKGDFTVRMPVDTVGVAGKVADTLNDIIDLNERMAKEFERIGTMVGKEGRITQRATVASAVGSWADCVESVNMLVADLIQPTTEMGRVIGAVAKGDLFQTMALEVDGRPLKGEFLRTARLVNGMVEQLGSFASEVTRVAREVGTEGKLGGQAKVKGVAGTWKDLTDNVNSMASNLTSQVRNIAEVTTAVARGDLSKKITVDVRGEILELKNTINTMVDQLSSFASEVTRVAREVGTEGKLGGQAVVKGVGGTWKDLTDNVNSMASNLTAQVRNIAEVTTAVANGDLSQKITVDVRGEILELKNTINTMVDQLSSFASEVTRVAREVGTEGKLGGQAVVKGVAGTWKDLTDNVNSMASNLTAQVRNIAEVTTAVANGDLSKKITVDVQGEILELKNTINTMVDQLSSFASEVTRVAREVGTEGKLGGQAVVKGVGGTWKDLTDNVNSMASNLTAQVRNIAEVTTAVANGDLSKKITVDVRGEILELKNTINTMVDQLSSFASEVTRVAREVGTEGKLGGQAVVKGVGGTWKDLTDNVNSMASNLTAQVRNIAEVTTAVANGDLSKKITVDVRGEILELKNTINTMVDQLSSFASEVTRVAREVGTEGKLGGQAVVKGVGGTWKDLTDNVNSMASNLTAQVRNIAEVTTAVANGDLSKKITVDVRGEILELKNTINTMVDQLSSFASEVTRVAREVGTEGKLGGQAIVRGVGGTWKDLTDNVNSMASNLTSQVRNIAEVTTAVARGDLSKKITVDVRGEILELKNTINTMVDQLSSFASEVTRVAREVGTEGKLGGQAVVKGVGGTWKDLTDNVNSMASNLTAQVRNIAEVTTAVANGDLSKKITVDVRGEILELKNTINTMVDQLSSFASEVTRVAREVGTEGKLGGQAVVKGVAGTWKDLTDNVNSMASNLTAQVRNIAEVTTAVANGDLSKKITVDVQGEIAELKNTINTMVDQLSSFASEVTRVAREVGTEGKLGGQAVVKGVAGTWKDLTDNVNSMATNLTTQVRGIAKVVTSVANGDLKRKLVVDAKGEIAELADTINGMIDTLAVFADQVTTVAREVGIEGKLGGQARVPGTAGIWRDLTDNVNQLAANLTTQVRAIAEVATAVTKGDLTRFITVSAQGEVAALKDNINEMIRNLKDTTRKNTEQDWLKTNLAKFTRVLQGQRDLLTVSKVILSELAPLVDAQHGVFYISERIEEDQVLKLLASYAYRERKGLSNTFKLGEGLVGQCALEKEPILLSDIPDSYIRISSGLGEEVPRNIVVLPVLFEGDIKAVIELASFHKFSDVHLGFLEQLTESIGIVLNTIAANMRTEALLKQSQALTDELRKQQEELTETNKRLEQQANSLQQSEELLKRQQEELRRTNEELQEKAKLLSEQKNEVEHKNLEVEQAKRALEEKAEQLSLTSKYKSEFLANMSHELRTPLNSLLILSQTLSENTDGNLTGRQVEFARTIHASGSDLLELINDILDLSKIESGTMTVDVGPLRFGDLREFVERTFRQVADKKSLQFDISLEGALPGEVQTDAKRLQQVLKNLLSNAFKFTESGQVTLSIQRARAGWSSDHPILRTAPTVVAFVVRDTGIGIPKDKHQIIFEAFQQADGSTARKYGGTGLGLSISREIARLLGGEIRLESEVGRGSTFTLFLPLKYVAPRPTETGQTLARVAANVQALPPPTVEVLAPEVEALHRPDIEDDSASILPGDAVLLAVTHTQDHATRLRAAAQGVGFKLLVSTEAESALEMARNARTVAVAVDLDLPDMAGWVVLDRLKHDAATRALPVYTVSGEDHRDRSLTLGALGHLRASADPSAAELALRELRSFVDRKARSLLIVEDDDVHRQALTELLGSEDVQTVAVSTAAQAQEAIAGRRFDCMVMDLGLPDLPGADLLRQLHAEHGASTPPAIVYTGRELTRAQETELRRLAEAIIVKDAQSPERLLEETSLFLHRAPAQLTEPKRRMLEKARERDPLLVGRKVLVVDDDVRNIFALNTVLERYGMKVAFAESGAEGISLLEKDTEVELVLMDVMMPEMDGYQAMRAIRGMERFAHLPILALTAKAMKGDREKCLEAGASDYITKPVDIEKLLSLLRVWLHVPRGATRPPRPEIPG
>NC_014623.1|WP_013377908.1|9269929_9270763_-|chemotaxis-protein-CheR
MSPPERGSELERLELELLLEAVWRHYGFDLRDHARPLLLRQLRRHLREERLDTLSALQGRVLHDADAMEGLLRALAGPSRPLFAEPAFFRSFRARVVPVLRTWPSVRVWHAGCGSGEETYALAILLMEEGLWGRCRLYASDASEGLLADARTGVIPLPDEEESRHYLEAGGRRALSDYYTRDGNWAVFSRALREGIFFTQHNLATDGSFNEFQVVLCRDTLLAYNRALSHRVHRRLYESLSRFGFLCLGRKESVASTPHAAAYEELEDSGRVFRRVA
>NC_014623.1|WP_013377907.1|9269390_9269933_-|chemotaxis-protein-B
MSPLGLLVVGAPREALEEVQAALAEMPARMPVPVVLVLHRGLHEVLAGPLGHRCPLPVVEPDDKEALLPGRVYLAPAGYHLLVDGNCVCLSREPAEHGQRPSIDALFESASEAHGPGVAGLLFGGHEDGWAGLAALREQGGRAAVTRAAEETEGVERVPPGGVKDWLARLVPVTRMKVLP
>NC_014623.1|WP_013377906.1|9268470_9269385_-|response-regulator
MSREKVPILVVDDQPEGVLALEATLAPLGHPVVVARSGREALRHLLHQDFAVVLLDVVMPEMDGFETAQLIREREKSRNTPIVFLTALSQGEVPEFRAYAVGAVDYLLKPFEPDILRSKVSIFVDLFRKTELVRRQAEALREVLQREHERERAELYQRLEAERLRVREEVLRKEMEAGRHHQRWLEALLSELPTPLALLEPGTGRTLFANRAAQGLAEGCLVYEEARRLRPDIVLTGGDHRPLSEESLPAARAVRGEVLAGVRVEWRSGEQQGAALAFSSRLPPMHGRPETALLALFDVATLTK
>NC_014623.1|WP_002614820.1|9267986_9268391_-|hypothetical-protein
MSDAAIPPRVQRFIATHIDSIEKLEILLLLRAHTSREWTAKAVSLELRITEASAVARLKDLSARRLLMEFETSPPTYRYHPATVEDAQDIAELQATYSLRRVSVISFIFSKPLDRVRGFADAFRLKRDKDEGDG
>NC_014623.1|WP_002614822.1|9267736_9267994_-|hypothetical-protein
MVEAVYILCGLTSLACTVLLLRGYRRTRTRLLLWSGLCFVALAVSNVILFVDLVLFPGRDLSVWRSASALVGIGTLLYGLIWDSA
>NC_014623.1|WP_187323663.1|9267451_9267712_-|hypothetical-protein
MLNGALVMGCLACALFFVRFWRASRDRLFVFFALAFLGMGFNWLALTLLDVDDERRHFVYVLRLISFLLILYAIWDKNRVRGAKAP
>NC_014623.1|WP_013377904.1|9264776_9267281_-|response-regulator
MSEEPPVASILLVDDHLQNLVVLGAALEPLGQRLVKATSGREALRRLEEEDFAVILLDVRMPDLDGYQTAHLIKAQERTRHIPLLFLTALQREDQHLLRGYAQGAVDYLLKPFEPEVLRAKVAVFVDLHRRNEALKLREARLREQEREALLRQGEAHARALLNAMPQAVWAARPDGTQAWCNAAWTALLGGNGAGPERHALVECVHPGERESVLAGIREALRSGRPWDGQHRMGRPEAYRWHHLKVTPLPASAEAWSGFLCTATDIDDEHRTQQISQLLSHASVMLSSSLDYHATLARLAQLVVPRFADWCTVDVLDRGASLAGLTRVAVAHAEQGKAERVLELHQRYPPREDDLSGVARVLLTGQPELLSELPEPMLRRMAMDEAHLELLREVGHQSRICVPIRARERNFGALTFGISGARPRYDRRDVALAEELGRRAAVAMDNALLYRDAQRAQQEAQEANRLKDEFLATLSHELRTPLTSILGWTQMLLRRDDLDEAGRRRGLETIERNARVQRQLVEDLLDVSRIAAGKLTLDLREVKLREVVDAALESVRPTAEARGVVLQAAPGEVSESVLADSTRLQQVLWNLLTNALKFTERGGCVRLEARREEAFVALTVSDTGKGIEAGFLPHVFERFRQGNTGRGHGGLGLGLAIVRTMVELHGGTVDVHSDGPGTGATFTVRLPLRAGLEASLTGEQAGEAPPLRGVKVLFLGNPVEARESVEGFLRNAGAEVRVVASLAEALTALAQHRPDVLVSDILLPGEDGFALMRNHEVRGRIPALALCGDTRMEAQRRILEEGFQMHLCKPVASGELTAAVSALLSRARGSAQEV
>NC_014623.1|WP_002614825.1|9280497_9281841_+|short-chain-fatty-acid-transporter
METLVRIAEGLGRFSARFVPSAFAIAVLLSLLTMGMAIGWAGAAPEAVLSGWGSGFWELLTFSMQMALVMFTGYLLALTAPVRKGLEWLAGLAKGPRGAVALMAFVSMALAYLNWGLSLVASAMLVRFVARRRPEVDYRLLVACAYFGLGATWHSGLSASAPLLVATPGHFLEKQLGVLSIDRTLFSPFNLGLTVAVVAGLTLLAWALHPKPENTVRVDPAVLEKLGDFVPPERPADRSLAVWLDHTRWLNLVFGVLGLLWFARHLALNGGWRALNLNVVNFLFLVLAVLLHGTPARLLKASEEAGGVLHGIVLQFPLYAGIYGIFKTTGLTDQIGELFVSMSTKDTFPAVVYLYSGVVNYFVPSGGSKWAIEAPYLLNAAGTLGVEPEKVVLAYAWGDMATDLIQPFWALPLLTVARLEFKDILGFLLLAFLLYLPFVTAAFFLFG
>NC_014623.1|WP_081465968.1|9281850_9283659_-|DUF5011-domain-containing-protein
MKTIPPRVNPPRLSRTVALCALWSALSACGPTPPVDSAPARDSSAASLPAHVAVAPSALTPSGEISVPPIHPLATQDQVTPVLAAGNGVYLVAWTEYIGNTIQLVAARVRASDGAVLDSSPIHIDAQPLPAGRVTDPAVSFDGTHFLVVYSKLEPSNRFYNEDIWGKRVRALDGAVVDSTPIRISNIANSDDTRHPTVIFNGTYYLVLWETLAYPSWGLYGAYVSPAGQLTAPSSFQVTSNVFSPQLAFGSGSDSLGVWTEGSQGKIVVGWFSGTAPLAILTFTVTESGGSNPAIAYNGDTFLVVWNEAGGIVKARRVRLSQVKGQPFSDTSFLVGEGATSPAVVSADPQSFLVTHHATRNGVAQLVSTRVLPDGVVPPNAEQTLATTPSTERPAFASLGTVQKAVAYKQYGPSTSYSRIKVRLVEDAQVEACTAGQPAVSLNGAATLTLECGSGPYVDPGAQAFNGCGAPLSVTAYNAGNDSFGSGPNTGAEGTYSVSYAAWDSTGAANAIRTVVVEDQTPPALTLKGPASSTHTCGSPWVDPGVEATDACYGNLTAQVWHTGEVNGWVEGTYTVNYTLTDSGGNSATPVTRTVEVVNCPW
>NC_014623.1|WP_002614833.1|9283778_9284645_-|glycosyltransferase
MLARPPLSVIIPWRDRPELGVTLQRNRRVFVANAYEVLVVSCGGAPKPFRRLLRARRFPGLRGVELPGVAFNKSLALNIGASLARSDRLFFLDADVVLRGDFLGESLKKLGTKHFLTVERVFESERPASERSTYLCELSYAMSFVDSKGRTAFVDTHHLNLREGSRGGPGMVLLRRKHFEAVKGMNSDLLGWGWEDLDLLVRLQLALGLKQRRHGRIVHLTHGDELRALEGESRGASEHRNLVRCLENYQRGHYGGTHEEDVQTWQGRLTVFEPSARRRRKQRLAARP
>NC_014623.1|WP_013377913.1|9284762_9285281_+|hypothetical-protein
MKKMLLRSVVCAAMALSSGALAQEAESAAAPDTAPVNKPSAEAVKDTWNYFYKGKDQGPVLVEAKICTEVAKDGPNKFDCITEVDPAVGVKANATGLMLWQSYLVPQGAVVEDIMVQTKQGTTVRETKDVKLKGEGWRTRQWTGLRLNKPGTWTIAILRGDQVLQEIQVKVN
>NC_014623.1|WP_002614842.1|9285559_9286942_+|hypothetical-protein
MVGWVRGMGGVFAAGWLLAGCEKPPPSAAGGGAGLEEARAVAGEGMGAMAGSRALALGVGQALRAAVAPDGDVLLVADYERPVSLGGKPLPFERGVSGPHLLVARVSPEGTPRWTQGWIPTGEGAVRAQVGAIAVAPDGGLMLAGTSAGFQVDQAWLAEGPFLARLSPEGHLQWARNFPGEGPFTVAALAVEPSSGEVVMAGDFGGRRDFGGGAHAVPVDRFGAFVARFTSAGVPRWSRRLGGPRGDVSVRAVAVGGQGEVVVAGGYSGAVNFGGATFATLLPRSPYVLKLSAAGDHHWSHDVPGAEGTAQAVALGPDRVFVAGTYTGRFFFQNGTFQSDWQDGFLVAYAEEGQSRWARSFAASATALATDGAGQVLVTGEHDGGSDWGPGGGAGLYVSKLLPEDGASVWSRGFTGTGAPRASTLGVDATGHAVVAGSLVQAQGTGHLPSREGFVLRLRP
>NC_014623.1|WP_002614818.1|9287145_9289659_+|sodium-translocating-pyrophosphatase
MTPTVSRMDALRKGVTGTAARVLGLLAVLASGTALASEADLILPDFASQSFLGGALNGYQLLLGGVVVCVLGLGFGFLQYGQLKNLPVHKSMLEISELIYETCKTYLITQGKFILGLWVLLLVVMVGYFGVLQHMLSEAPAKLFAILIFSLIGIAGSYGVAWFGIRVNTFANSRTAFASLRGKPYPTYAIPLQAGMSIGMVLISTELLLMLIILLAVPSDFAGPCFIGFAIGESLGASVLRIAGGIFTKIADIGSDLMKIVFKIKEDDARNPGVIADCTGDNAGDSVGPSADGFETYGVTGVALITFILLAVPPAFQVQLLVWIFVMRIVMVVASLLSYFVNEVIQGGKYKNADKMNFEHPLTFLVWLTSFVSVALTFVVSYLLIPDLAGDGSLWWKLSAIITCGTLAGAIIPEAIKAFTSTESRHVREVVTASREGGASLNVISGIVAGNFSAYWMGIIIAGLMAIAYWVSIDVPNTLMLAPAVFAFGLVAFGFLGMGPVTIAVDSYGPVTDNAQSVYELSLIENVPNVKAEVAKDFGFTPDFEKGKEYLEENDGAGNTFKATAKPVLIGTAVVGATTMIFSIIVLLVGTETVNGVLSLKTEGLGNLSLLHAPFLLGLVTGGAVIYWFSGASMQAVSTGAYRAVEFIKANIKLEGVEKASVTDSKRVVEICTQYAQKGMLNIFLGVFFSTLAFACAEPFFFIGYLISIAIFGLYQAVFMANAGGAWDNAKKLVETELRAKGTDLHAATVVGDTVGDPFKDTSSVALNPVIKFTTLFGLLAVELAVELNKSGNGGLTRVLAVVFFLLSLVFVYRSFYGMRIESPVGSESAKTHAKAA
>NC_014623.1|WP_002614821.1|9289739_9290060_-|hypothetical-protein
MSQPGPQARGSTVRAALEAALMAAPEAGLTARELSAAVGIPEKDVAEHLVHLQKSLQATGGRLKVLPAECIACGFVFRDRKRFTRPGACPECRATRVDPPAFRAER
>NC_014623.1|WP_002614815.1|9290056_9290602_-|hypothetical-protein
MADPTQENRSPSLRGGLLQAGSGALHPLLDRSAAAGIPAHPLPGDLPLRRWVPQGAHSLLDYAVGLGVAGASSLSEAPSARRAGVALGLGLVGLSLLTDTRLSLSRLVPIELHALADCGWGLAALAAPFVGGYARRAPALAAVQAVAGAALLVASLLTDYRCTSGMHLGRERMTDLGPVGA
>NC_014623.1|WP_002614814.1|9290843_9291047_+|cold-shock-protein
MATGTVKWFNDAKGFGFLTQDGGGEDVFCHHSAINMDGFRTLAEGQKVSFDVTRGPKGLQAQNVRPA
>NC_014623.1|WP_002614829.1|9291118_9291457_-|STAS-domain-containing-protein
MKITSRSVQGVEILKPEGKITIGVGDVALRNAVQESLARGTTKLLLDLSGVTTVDSSGVGELVSAYTRVTSRGGKLKLFGLPSKVQDILTITQLITVFEVYDSEAEALASFS

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Crispr_ID: NC_014623_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014623_8

9468362-9468479

Orphan

Consensus_repeat	Method
CCCAAGCCGGACGCGAAGCCCCAGTTCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014623_8

>merge|NC_014623|8|9468362-9468479|CRISPRCasFinder
CCCAAGCCGGACCTGAAGCCCAGCGCTCCCAAGCCGGACGCGAAGCCCCAGTTCACCCCACGCCCCGACATCAACGGCAAGCCTCAGCTCCCCAAGCCGGACGCGAAGCCTCAGTTCA

>NC_014623|8|8|9468362-9468479|CRISPRCasFinder
CCCAAGCCGGACCTGAAGCCCAGCGCTC	CCAAGCCGGACGCGAAGCCCCAGTTCACCCCACGCCCCGACATCAACGGCAAGCCTCAGCTC
CCCAAGCCGGACGCGAAGCCTCAGTTCA

Protein	Signature genes	Signature genes Name	Protein_function
NC_014623.1\|WP_002612135.1\|9477683_9478175_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|176528
NC_014623.1\|WP_081465971.1\|9477160_9477655_-\|glutathione-S-transferase-family-protein	unknown	unknown	gnl\|CDD\|223698
NC_014623.1\|WP_002612196.1\|9474519_9475071_-\|RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|224511
NC_014623.1\|WP_049805211.1\|9463156_9465496_+\|kelch-like-protein	unknown	unknown	gnl\|CDD\|276965
NC_014623.1\|WP_002612156.1\|9475181_9477089_-\|M23-family-metallopeptidase	unknown	unknown	gnl\|CDD\|366703
NC_014623.1\|WP_002612140.1\|9479057_9480659_-\|acyl-CoA-synthetase	unknown	unknown	gnl\|CDD\|181011
NC_014623.1\|WP_002612148.1\|9455134_9455674_+\|DUF1318-domain-containing-protein	unknown	unknown	unknown
NC_014623.1\|WP_002612170.1\|9447137_9448367_-\|hypothetical-protein	unknown	unknown	unknown
NC_014623.1\|WP_148273507.1\|9473235_9473745_-\|hypothetical-protein	unknown	unknown	unknown
NC_014623.1\|WP_002612139.1\|9448394_9450035_-\|aromatic-amino-acid-lyase	unknown	unknown	gnl\|CDD\|376303
NC_014623.1\|WP_013377994.1\|9459311_9459674_-\|J-domain-containing-protein	unknown	unknown	gnl\|CDD\|365959
NC_014623.1\|WP_002612174.1\|9451451_9455138_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225463
NC_014623.1\|WP_002612183.1\|9470342_9473069_-\|CHAT-domain-containing-protein	unknown	unknown	gnl\|CDD\|378942
NC_014623.1\|WP_063641061.1\|9480745_9481795_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197715
NC_014623.1\|WP_013377997.1\|9465548_9467876_+\|branched-chain-amino-acid-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|276965
NC_014623.1\|WP_002612193.1\|9473812_9474523_-\|hypothetical-protein	unknown	unknown	unknown
NC_014623.1\|WP_002612158.1\|9459808_9460273_+\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|377770
NC_014623.1\|WP_041792254.1\|9478314_9478722_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|373000
NC_014623.1\|WP_002612163.1\|9455667_9459258_+\|PD40-domain-containing-protein	unknown	unknown	gnl\|CDD\|223893
NC_014623.1\|WP_002612133.1\|9460375_9462061_+\|peptidase-M14	unknown	unknown	gnl\|CDD\|349445

Protein	Function_ID	Function_description	E-value
NC_014623.1\|WP_002612135.1\|9477683_9478175_+\|hypothetical-protein	gnl\|CDD\|176528	cd08586, PI-PLCc_BcPLC_like, Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins. This subfamily corresponds to the catalytic domain present in Bacillus cereus phosphatidylinositol-specific phospholipase C (PI-PLC, EC 4.6.1.13) and its sequence homologs found in bacteria and eukaryota. Bacterial PI-PLCs participate in Ca2+-independent PI metabolism, hydrolyzing the membrane lipid phosphatidylinositol (PI) to produce phosphorylated myo-inositol and diacylglycerol (DAG). Although their precise physiological function remains unclear, bacterial PI-PLCs may function as virulence factors in some pathogenic bacteria. Bacterial PI-PLCs contain a single TIM-barrel type catalytic domain. Their catalytic mechanism is based on general base and acid catalysis utilizing two well conserved histidines, and consists of two steps, a phosphotransfer and a phosphodiesterase reaction. This family also includes some uncharacterized eukaryotic homologs, which contains a single TIM-barrel type catalytic domain, X domain. They are similar to bacterial PI-PLCs, and distinct from typical eukaryotic PI-PLCs, which have a multidomain organization that consists of a PLC catalytic core domain, and various regulatory domains, and strictly require Ca2+ for their catalytic activities. The prototype of this family is Bacillus cereus PI-PLC, which has a moderate thermal stability and is active as a monomer.	5.95082e-31
NC_014623.1\|WP_081465971.1\|9477160_9477655_-\|glutathione-S-transferase-family-protein	gnl\|CDD\|223698	COG0625, Gst, Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones].	5.59083e-30
NC_014623.1\|WP_002612196.1\|9474519_9475071_-\|RNA-polymerase-sigma-factor	gnl\|CDD\|224511	COG1595, RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription].	5.37512e-16
NC_014623.1\|WP_049805211.1\|9463156_9465496_+\|kelch-like-protein	gnl\|CDD\|276965	sd00038, Kelch, Kelch repeat. Kelch repeats are 44 to 56 amino acids in length and form a four-stranded beta-sheet corresponding to a single blade of five to seven bladed beta propellers. The Kelch superfamily is a large evolutionary conserved protein family whose members are present throughout the cell and extracellularly, and have diverse activities. Kelch repeats are often in combination with other domains, like BTB and BACK or F-box domains.	1.07083e-37
NC_014623.1\|WP_002612156.1\|9475181_9477089_-\|M23-family-metallopeptidase	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	5.55221e-08
NC_014623.1\|WP_002612183.1\|9470342_9473069_-\|CHAT-domain-containing-protein	gnl\|CDD\|378942	pfam12770, CHAT, CHAT domain. These proteins appear to be related to peptidases in peptidase clan CD that includes the caspases. This domain has been termed the CHAT domain for Caspase HetF Associated with Tprs. This family has been identified as a sister group to the separins.	1.14816e-51
NC_014623.1\|WP_013377997.1\|9465548_9467876_+\|branched-chain-amino-acid-ABC-transporter-substrate-binding-protein	gnl\|CDD\|276965	sd00038, Kelch, Kelch repeat. Kelch repeats are 44 to 56 amino acids in length and form a four-stranded beta-sheet corresponding to a single blade of five to seven bladed beta propellers. The Kelch superfamily is a large evolutionary conserved protein family whose members are present throughout the cell and extracellularly, and have diverse activities. Kelch repeats are often in combination with other domains, like BTB and BACK or F-box domains.	5.30185e-38
NC_014623.1\|WP_002612139.1\|9448394_9450035_-\|aromatic-amino-acid-lyase	gnl\|CDD\|376303	pfam00221, Lyase_aromatic, Aromatic amino acid lyase. This family includes proteins with phenylalanine ammonia-lyase, EC:4.3.1.24, histidine ammonia-lyase, EC:4.3.1.3, and tyrosine aminomutase, EC:5.4.3.6, activities.	4.90437e-156
NC_014623.1\|WP_013377994.1\|9459311_9459674_-\|J-domain-containing-protein	gnl\|CDD\|365959	pfam00226, DnaJ, DnaJ domain. DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature.	2.46671e-21
NC_014623.1\|WP_002612174.1\|9451451_9455138_+\|hypothetical-protein	gnl\|CDD\|225463	COG2911, COG2911, Uncharacterized protein conserved in bacteria [Function unknown].	4.05472e-06
NC_014623.1\|WP_063641061.1\|9480745_9481795_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	3.64898e-12
NC_014623.1\|WP_002612140.1\|9479057_9480659_-\|acyl-CoA-synthetase	gnl\|CDD\|181011	PRK07514, PRK07514, malonyl-CoA synthase; Validated.	0
NC_014623.1\|WP_041792254.1\|9478314_9478722_+\|hypothetical-protein	gnl\|CDD\|373000	pfam14295, PAN_4, PAN domain.	2.11068e-09
NC_014623.1\|WP_002612158.1\|9459808_9460273_+\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|377770	pfam07080, DUF1348, Protein of unknown function (DUF1348). This family consists of several highly conserved hypothetical proteins of around 150 residues in length. The function of this family is unknown.	1.02281e-92
NC_014623.1\|WP_002612163.1\|9455667_9459258_+\|PD40-domain-containing-protein	gnl\|CDD\|223893	COG0823, TolB, Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion].	4.92998e-09
NC_014623.1\|WP_002612133.1\|9460375_9462061_+\|peptidase-M14	gnl\|CDD\|349445	cd06226, M14_CPT_like, Peptidase M14-like domain of an uncharacterized group of Peptidase M14 Carboxypeptidase T (CPT)-like proteins. Peptidase M14-like domain of an uncharacterized group of Peptidase M14 Carboxypeptidase T (CPT)-like proteins. This group belongs to the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding CPs which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key determinant of specificity. CPT exhibits dual-substrate specificity by cleaving C-terminal hydrophobic amino acid residues and C-terminal positively charged residues. However, CPT does not belong to this CPT-like group.	1.18994e-158

>NC_014623.1|WP_013377997.1|9465548_9467876_+|branched-chain-amino-acid-ABC-transporter-substrate-binding-protein
MRNVSTRLLLALGLALLAGCSPTPSTSGSARLAVSTRKAVTSVPSGISRVTVTSSAEDMSPLPVELKLANGVWGGIIGDIPAGSDRTFQAQAFDSWGNLRFEGTASGITIGAGQSSLVAITLQEVNAPPPYINESPLIDSLVVSSSTVLAGDTLLLEATAHDPNESDSFWYSWSATGGYFFSDYNHTTAWQAPSSSGVYRLTLTVTDSAGTSSSISLEVVVHGGAEGSAEITISFNGSPGVSSVRASRSPLEVGQTTTVSAAASDLDGDTLSYAWSANCEGSWEDASSSTAQFTPTALPPGVCNNCHLTVTVSDDKGGQTTGTVALCVNTPSTGSHSPPSIARSYRSSDTASANQVLTYAVVASDPEGSALSFSWTANSGTLGTAASGPFNSSITWKAPLCAGVGVSPAITATVINAFGMTATRSFPITGLPTCAPGTWASTGALSTARQYATATLLPNGKVLVAGGYHSTYSYTYLATAELYDPATGTWSPAGAMASPRYQHTATLLPNGKVLVVGGYAGSSGALATAELYDPATGTWSQTSTMASTRYNHLATLLAHGKVLIAGGNGGSSGTLTKAELYDPATGTWSPTGSMTTSRQYATATLLPDGKVLVAGGSGYYSGLTAAELYDPATGTWRAARSMVSPRYNHSATLLPNGKVLVAGGYNYDPMATAEVYDPSTDKWSTTGSMISPRSSQTATLLPSGKVLAVGGASYYANQTTAEVYDPSTSTWSIAVPMTVPRSSHTATLLSNGDVLIAGGYSYWDGTLKAAELFKP
>NC_014623.1|WP_049805211.1|9463156_9465496_+|kelch-like-protein
MRTSFTPLLLTMSLALLASCSPSSSSHKTGSARFIVSTRQALTTAISRITVTTSAADMPSATVDLVLTSEGWGGTLGNIPVGAERTFQAQAFDSAGTLRFEGTASGVWIWENAAVLVAISVVEVNAPPPFSNEAPFIDSLVASSLTVATGGTLLLEATAHDPNPGDSLSYQWSSADGSFSSLHTSATQWVAPSSDGAHGLKLTVTDSKGLSSNLSLVVTVQGESRGEVRPSLSFNSWPVVSAMTATPSPLKVGQTASVSASTSDADGDTLSYAWSATCEGSWDNAASRTAQFTPTEQPGGACNNCNLIVEVSDGQGGQTAGIVALCIGGTAPTIPPSAPYIARAFSSSDTATAHQVLTYEVAAKDPQGAPLSFSWAANAGTLGVATEGGSNSRITWTAPACVDENLTLTITATVTNPFNLSNTRSFGVSGVPACSHAWTSTGALSTPRQHATATLLPDGKVLIAGGDSGTYPVSHLATAERYDPATGTWSPAGALSTPRQHATATLLPNGKVLVAGGQGSSPIALATAELYDPATDTWSATGAMASTRYRHMAVLLPNGQVLVAGGYDYYSGALAVAELYDPATGTWSQTGSMAASRPYATATLLPNGKVLVAGGYGYYAALAAAELYDPTTGTWSQTGSMATVRYSHTATLLSNGQVLVAGGYDDSSGALAVAELYDPASGTWSATSPMTFPRYHHSATLLPSGKVLVVGGSAGGGSGLELNKTLLYEPGSGTWSRHGSLGTSRYFHSTVLLANGQVLAAGGYGYWDGTLATAERYTP
>NC_014623.1|WP_002612133.1|9460375_9462061_+|peptidase-M14
MPLHAAGALAVAALTLSPSPSPTSSPGDAVLPASRPGTEAPSRPSLILARVFFKDRADLNRLAETLDLSAAVDREKRSVEAVLSPEEYDALVKEGRRVELLEEQTRLMNAPRDGMRILAGIPGYTCYRTVDETYAAMARLATTSPNLASWNDIGDSWDKVTAGGKPGDDLRVLVLTNKSRSGTKPRFFLMGGIHAREYTTAEVAARFAEQLVSRYGTDADATWLLDYYELHVVVQSNPDGRRIAETGLSKRKNTNTSLGSCSTTTYGVDLNRNSSFDWGGPGASTSACSETYRGRAAASEPETQALENYIRSIFPDQRGPSLTDPAPADATGLMVSLHSYGGYVLYPWGIGTASSPNATQLRTLGRKFNYFNGYEACQSSLCLYDAAGATDDFTYGTLGVAAYTFEMGGAFFESCTTFENTIYPKNLSALYYAFKAARRPYQTPAGPDSVSLTLSASTVTAGTSVTLTAQANDTRYGTNGGTEASQAIAAARFSIDNPSWVSGTPTYAMSPVDGSFSSSIESVRGTVFTSGLAPGRHTLFVESQDINGNWGAPTAIFLNVQ
>NC_014623.1|WP_002612158.1|9459808_9460273_+|nuclear-transport-factor-2-family-protein
MDRPPLPPFTAETAAIKARLAEDAWNSRDPARVAQAYTHDSRWRNRAEFFQGREAIQAFLVRKWQRELGYRLIKEVWAFTGNRIAVRFAYEWHDDSHHWMRSHGNEQWEFDEHGLMRRREASINDVRITEGERLFHWPQGPRPQEHPGLSQLGL
>NC_014623.1|WP_013377994.1|9459311_9459674_-|J-domain-containing-protein
MVDLYTVLSVAATADARDIRRAYLRLVQQYHPDRDARPESTERFLQFQAAYEELVDPEKRQRYDARRPGCSTPTSSHPGQAGVPFRDVETARTSEASRDAAPRPAMHGHWAHVSVKVRLH
>NC_014623.1|WP_002612163.1|9455667_9459258_+|PD40-domain-containing-protein
MLTFRGGLFLALAVLLTCAAWAQDDENDGGLRTPTRLTVGMGDHFLGQLEPDGKRLIFVSNRNIATEIYAQDLEGGRERRLFDEGADVTWPRISPDGKHLLYISFRDQAGGQLCVRTLPAAEERRCLDEESSAVQAEWIDASHVALVSRAAIQGDLHLSRVDVALKLSAKPLLERNLTSPALSPDGRWLVYVPIERAVPQVGPGFAARAARHLEVLRLDRPGAAPIPLTLDLPGQTGQPVFARDGRSLYVVQFFTDSNGDEVIDASDSGVLFRVPFAAERDDAPELAAASSPDQLTSVAWNCEYPAPAAESLIATCSRDRTLDVYQLPLDGQVPSHWDVPRLNEELRMVGRRADQLLLYRQRLLLEARPKPRRLLMMRLSYLHLAFEDFDAAGFYARGMRSVNDPATAGLAEPLHILIDHRRAMKERERGRMVDELSETERQRMAALDPAAAPSPPSTVFQHVVRSELAEDAGDFTRARQELEAAQLTDTTPRAVLEAWFERADSLYRKLDDREALVEAGRRLSLNKVFHEDDQLDFARAAVRALYRGHPYDQADAAMAQALASAPAGSAYAFALEMGRRVNAVHDERPPRPVRDALIAFYQQQKDPLRRRALVQDAVERAASLGADGVLEALATVYVDDTPAGTEERRRAERLFRRAMTGRAYRRLGRQRLDDARADFDLVTQRTGSLESAVESINLRLRAGTSPEKVEKEVTTTAAKMAEPLAHFVKAYLMACRLPELDDEAHAQTVSAAVKELRVSWKELKSQRAVQALSGAIHHEDFLRRQDPAAAERANRHYLIALDLVRNNVRYRAMILGALGLLHTQVGNFHIALEYLEQRDKLPYVDNAAGLAVSLARARALLHVGREEEAAKTADQALARLDATPELAGFVLLALDRAALYNLAAGRFKRALALYDRELLLLDAEARDQEGLRNRLVVRLARSAAKLGGEQPQQALEDLAIVDRDLADPAVQATLGWRRATPEHVMRSYRIIAAGLRANAETRLGRLDAAARALEQRRALFLKQFDELDRDQDVGEVTLAELRLAENAADRRDMAQAARWLGEAIAHADTLIERTHAPVDAGQLGVLWLAAQVHAEGSTQLPFDVPKRLGQAHRSLIDQRSPAWRSYLAWFEIYLALGADPLPSLQRARSSSASGALPVAPQPLPPESSPSPGAPVPASGLPSPVPPSPPPQNQTST
>NC_014623.1|WP_002612148.1|9455134_9455674_+|DUF1318-domain-containing-protein
MKHRGLLLLAALAAPGCIRAPEIVMVDRATALEEQASGSFQDMERRLARSGMSPAPVPLTPNQLEELGLQPTPLVENMGKTQADRVDDLLRRHCVGEARDGLLVDTRRSCQAGRLSADDVALVERVNRARLQLWHWMQTLRPGVPEESLRQSWRQFHAEGVVCGGWVESDDGTWGEKKC
>NC_014623.1|WP_002612174.1|9451451_9455138_+|hypothetical-protein
MESSGAVRPRRRLARIIAGVLLGLVATLVLVLAAAVVALHHLEHLWLKPRIVSQVEAATGLQLDYQTARIAVLSGLRLEGLVVRTPSPFQGVAPDLLRVGSLEVQWSFGALLSKSPRVERVTARDVALALVADEAGLTSFSGLMGPAAPEPPPVKPPLGASQQVAAFLASAPPFGKAEISGVSLSFTRVRSGEVLERWSLGGLAVTVEAKHQDDGWKLLATTGQTGAPLPVELVREGSAHPPAQASLELIFSAEAGASAARTRVDLDIARQTFDPQFTVRSLLHGTASARFDGEKRHITIELDRTQLTDSAEVQARLVLPDAAEAPPVVTRALVDVELGRLLQWLPAEWRLFSLERGKVHLDAQELTLSALPQLGAQGRLGLDVDVAALQLAHGDSRVALDSGRISWVAAPDPHQGLSTQLAFALQRLDVGGPTTLLVPKVSGELKGQQLRPDPSSPIKVAGDAVLSGKVDALDVRAAGIRATAERLGFQLQAPLTGEPPFALKADVPIGALRVVMADGREVLKGPVHVKLDVSKAFPQMEEPRLSRARARLELDVGTVHASLDATKGADDVAYTLSLQTPDLVAARPFIPESVAARVPWKHLAVNLASTGRLAGLFSPSPRLEHRTELRLQRPGWDDVSAGNIAAVMSSQGDAWRHKGELDLQIEGLRIGETEAGSQHQTLTLDLDRRKPSLRLGLQSHAGLKMPLDAALAFDRKARALRLDVKGELPPLGALSPLLAKAQMPAELDTSRLALNIELQGTLLGAITDIAPDGTLSLAPDPRRTASFEGKAVVDARGIRWRQEGLSINLPALRWQVESDVDGPHRSVHSHLTVERLSLGLSDRRLTFADLASDTTATFTGQWEAGEIELKQLLKARSLEQKPALPYPVQDLEGSFSVRWKPHGVIHIPDLSLSHAGTQTLLKARGRLDLSDNGRRLAVQGSLEQDLSKLAQPGLLESSGKATVEFRVASPDLVVFRTLSNLLLQNVNVRLPESGIAIEALDGNVPVNGNVELTGSGVRLLSDIDTNPYSMLRFADQHPLLTRSSFMSASSIITPFVSIAPLAGNLSINQSVVSMSQLEMGVRGGRITGQCVLDWQGKHSLLEAHVRATGVRSSRGEPFDGNAAVVISGKDRSINGRAEILRIGNRHLLDLLDLEDPHHADPATNRVRYALGLGYPKHVRVSFNHGFGRLAITMGGPASLLSIDEIRGIPMGPIIDRVINSLSLPEATP
>NC_014623.1|WP_002612139.1|9448394_9450035_-|aromatic-amino-acid-lyase
MSQTALYVIIAAMFLRAAPAQADVTLDGKSATPEAIAAIAQGQPVKIAPEAFKRIEQAHRVLLQAAAEGQTIYGLTVGVGLNKDRAMVDAQGKLTEEVIEASRRFQVGLIRAHSGSVGPEMDVRTVRATMAARLNTMLVGGAGVQPEVIDAYVQFLNRGIAPVIPTGGSLGEADITIISHVGLAMLGEGEVYYKGQKTSAAKALQAAGVKPVKLFGKDALAILSSNAYSAGLAALALNDLSHLITVNKLVYALSLQAINGNVSPFLEDTLALRPFPQTVRAGAELRELLSGSSLWNQDATRRLQDPLSFRDSVYVLGEVTRTYDEARGLLNIQLNSSDDNPGVAVNVTPKSQRWQEKKSYVAADTAGAVLPSANFEPLPWVLAFEQLGIALAHNSLTSAQRIIKLDDPNITGLERYLGTEKTVHAFGAMEKPVVALALENKVLATPVSTEFLPVAGGIEDIATNAPEVVKRVQKQIDNSYALLGIESIHSAQAIDLRRASRKEFTLAPATTKLYGAVRRKVAFLDEDRPLTPDFRAAAEVLRNYHD
>NC_014623.1|WP_002612170.1|9447137_9448367_-|hypothetical-protein
MSNPRSRPCFPALMMGALIMATSTAARADEDDAPLGVFKLGDGTLKVGGVLRVRLDATLDDPKPTSGISWDVAWLSAKYDSPTLFGAFQYRFYGGTNAIGYADTTNLGQENYLTFAYLGYNLTHEHKLALGMHQVPFGILPWVSSSFYQTMANVIGLEDVHNVGIKYNYSGGALTLDAAYYLRDGGSYFGPTEDANRYSIGFVRHDSYVEGGTNSRERHQFIGRVAYKFAHGTESSSEVGASGLYSRIQNLDTRESGGRLATALHLVGNYGRVRTMIEAGLQRIDPRNPDQNTSLITMGGFGGSFNVATKGKFLSVDLSYSVPGSWAYVSGVRPYLNYSVFAKDEAAFKTSHRFFAGTSFSLYDRWWIAAEFRFGRNDPYTGSYVNGLGVGGDDLWHKAYFMNVGYYYP
>NC_014623.1|WP_002612183.1|9470342_9473069_-|CHAT-domain-containing-protein
MCFFREAQAPARREEARRRLRGLLASYPDRPWLMLVLGHLEMLSEPRLAEASYRSAALAFRRLEDAEGEVMAGINLRNVLGVLGRTEEAHTWVQRVGEVARASGNAQLQVRALILEAAELSDLGQDLGRAYRLLKRAEALAFPGGSDGVKKQLLTPLASVSANLGRFDEALDAYARLAELARSTHDVGTEARVRFAFANLALRRGEERPELGGRPELLRLAREALAAAKNAGSKAFEAQSLRLVAELLGDSPEERSEAEGHLERCLDLARDAGLPERRIACLWTRAERLAGVDAAAAERDADAALALAAEHDNPRYLASAWRARSMVAFRTKPLPEALRQAERALDAVEVLRQLQKDASSQAELFSGWANDYHRLAGRTLEAGETSALPSREALERAFAVSERLRARTLFEALVASRALVSAEDTPERQESRAGVLRDLSATQRRLLEKELSASERTRLLGELQELERREHELRPTPRHAEVRFASLAQTERGLGPGEALLVFLVGAVQDLQGVPAGGAWVLAVTREGTRAYRLPERARLRPAVALLSGLIERRDGSEAGAATALYAQLLAPALRELPPGVSRLLFVPDGPLHDLAFAALRERADGPPLIARYELALVPSASLLHHWRQRAVRPPGGEALVLADPDRGAAATAVASARGGVFGEMANLGSLPEARREGHTVEDSLEDTVVRPRLLVGAAASEQALKASRLEDVRILHVAAHAVVDVDAPERSALVLAPGAEQEDGLLQPREITGLGLGDALVVLSSCQGASGTLLAGEGVLSLARAFFEARARAVVASLWPLRDAEAAWLLERYYRHLASGQGVSQALRSAQREAWEDGQPAAAWAGLGVMGDAALVPVPSNEAKAARPGGTALGLMLGGGALGLYALTGWWRRARKGPRADTTRGAG
>NC_014623.1|WP_148273507.1|9473235_9473745_-|hypothetical-protein
MKTLNAVRGWMRAVAAMVLLWGLTAAAQAAPPMTVMTTVPVSGAAHDAVVASVMDVGVSRGGTLTVTLRILSDRGVVLAEITGPVTEGFPLRLSATAPTSAGVRAQLLLPPNTEALAAGVLVLERWTGTAPSIEPPPVCRIPRTNTIDPRGGTPEPTTSLECSYLFIRD
>NC_014623.1|WP_002612193.1|9473812_9474523_-|hypothetical-protein
MSEHRPEDDSIDDAGVERLRKALRDEDAAAGEPVDAERVWRAVTQDLPAEERRAVIERVAADPAWAQAWRLARTMSQAAAKADAPAKVLSLTDRKARGKRSWGGRPAWVAMAAMWVVLVGVVVVLRQQQQGEDPDRIRGGEAEAITAVVPDAAALPRDRFVLRWRGVAQATQWSVQVSSEDLKVFHRVERLEQREYTVPASVLAELPSGARVLWQVEARLPDGGVRRSSTFVNRLQ
>NC_014623.1|WP_002612196.1|9474519_9475071_-|RNA-polymerase-sigma-factor
MHLEMRHGHSAGASPDAGLETLRRDLDKALASVCPPSLADRRDDLLQVAMMRVVELRKRDPGHAALSSAYLYRVAYTALIDELRRVNARKEVALEEGEQAPVQPVAPGDPERSAGAAQIARAVRDCLQGLMQDRRLAVTLHLQGHTLHEAAELLGWESKRTENLIYRGLSALRACLSTKGVTP
>NC_014623.1|WP_002612156.1|9475181_9477089_-|M23-family-metallopeptidase
MSSRLRSAVRLTAVAVATVSVSASAQTYAFPGSSADLPEGSHWWISSDHSGTENRDLSAVRFDATERRFTRVKIPFADYAVNPKNSDWVIYGLPVTAIADGEVLTCWRNAPEGLKPAVHGGDDVPHPGRTANPPIIPRSGNHLNIRTNDGKIILYAHLQPGSIPESLCPFNNTYVADAEDRVGDLPREVMVPATQRAFVKRGQFIGRVGSSGASSNPHLHVHLQPMTSETTMGNSLPLPFSQAWQKDGAVNYDSSLDFVPLRSEALNQFPSAIHPDPLLRRGSITGDAAMEVALASSGDTVVSATRDISGRLVMGSWRLAGDGTFTKLSGITTPDASTYVSIANPGLGRDVVTAARAADGKLKLIAWRVSATGLFSRQAEAGGDVVSSQMALAPIPGGSLGVVSAVRDSAGRLKVSTWETSSSLDTITRRGNGFGEEATHVSLAPVAFGRVAGDTGYFKGVVTAVRTPAGKLSVTAWEIGSTGLVYKRGNDVGGDVADVAISNLTIGNNVRDVVVVSARLPTGVLRNISFDITDAGELVRRDDEDASGVLDVQAARVVGQHLVTPVRDSGGNLRVFTWDVDANSQVHRTGQELAGDILDGMAITSTYVGARFVITGVRLTSGGDVRLIAWDANLP
>NC_014623.1|WP_081465971.1|9477160_9477655_-|glutathione-S-transferase-family-protein
MKARRSSLKENKAPEFLKINPAGKLPALVDGAARVFENAAICLYVADKYPQAKLAPKVDAPERGRYLSLLVYSTSQLEPSMADHMTGTKTLPQRGWTSYSEALDAMERELGDGPYLFGDWFTAADVMIGSMFSYQRMLGGKTGRPKLEAYVDRLAARPKGLKVG
>NC_014623.1|WP_002612135.1|9477683_9478175_+|hypothetical-protein
MSLQHPPSPHRATASLLLSLFTVLAPLHLAAASNSDWIDTNFDNVLLSVRQFLINHPAETILMRVKEEHSPESTTRSFAETFEWYRDQPDYAPIIWRGTTVPSLGQVRGKIVIIDDFSAGESYGIRWGELAIQDAYDFTDTDLQWELVRNHLLAAKTGDINTL
>NC_014623.1|WP_041792254.1|9478314_9478722_+|hypothetical-protein
MPDGDAPRCKAFTYVKAGVQNNDRVLCYLKDGTPAPVLNANVDSGPTLANPSVGLYSGLVETHVDRPDQDYRSFDLSQAQPELCREACRNESHVCKAYTYLRPGGGNPLPRCFLKSGIPAPVASPRSDSGINVGP
>NC_014623.1|WP_002612140.1|9479057_9480659_-|acyl-CoA-synthetase
MTTPHAPSTPPGEHRPESPCSILEVFLEHARKTPDRLALSFEAKRYTYGELARHVTALAQALLRRHLKPGERVALYLENSPAFVIAYLGVQYAHGIVVLVNTQYRQVELDHILTDSETRVCVTGAAGATELTPLLGGLPALEWLITAEPLTASPPPSLTVLSLDTLLAEPVEERPMSVPGGSDIAVLGYTSGTTGRSKGAMLRQSHLLSNIRAVTQAWRWTEQDRLLLALPLFHTHGLMVGLHGTLYMGASVDLRRRFVASETLETLRDDPAITLFFGVPTMYGRLLEESRRTGVRPRPLRLMVSGSAPLSAQLFHEIEAEFGQRILERYGMTETIMNTTNPYEGERRPGTVGMPFPGQEARVVDVRTRKPVPDGEPGEIEVRGPHVFAGYWRREQATEEAFDKEGGWFRTGDLGLRDADGYFHITGRARELIISGGFNIYPREVEEVLATHPGVGEVAVLGLPDPDFGEQVVAVVVPAAGQPVPGVQALVDWCKDRLASFKKPRRVEFVDALPRNALGKVQKHVLRERLLPR
>NC_014623.1|WP_063641061.1|9480745_9481795_-|helix-turn-helix-transcriptional-regulator
MAALTSSLDLAEVFSESHKILSRVLAADFGGLCVSRPGEPDQYDWPMVHEMPQVFFDRYPEISDECFVSFAVIQRPNTVLRDSEMLSRQAMRNSAMYAHCREMNMPVERVMSVLLDVGLDWHGGFTLYRESRRPFSDQERAFLQRLTPILARTVRNCRLMGDAVQQGAIMDRLFHQAGFESIVLSPPATELMRTPRSTELLHRWFKGAPCGRLGLPVVLLDTLERLSRSERLVLSEQDVLVFRRPERSLKVTFLRLPAQLGRRPWALLLQEVSHAVPAPREWRKRLTPREMEVVERVLKGWDNRTISEDMGGSMNTMKTHLKRIFVKLAVPSRAKLILLAQELNAEAAG

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Crispr_ID: NC_014623_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014623_9

10193893-10194068

Orphan

Consensus_repeat	Method
GTGTTCCACGTGGAACA	PILER-CR

3 spacers

The CRISPR arrays of NC_014623_9

>merge|NC_014623|9|10193893-10194068|PILER-CR
TGTTCCACGTGGAACAAGGGGACGCCCGGCGGGGCGGCGCCGGAGCGAACGGGCAACCGGGGTGTTCCACGTGGAACATCAATCTTGAGTTCTCGGCCCAGACCGGACCGGGTGTTCCACGTGGAACACTGGTCCGGGTCGAGGTCCGCCGTCGGCCGCGTGTTCCACGTGGAACA

>NC_014623|9|1|10193893-10194068|PILER-CR
TGTTCCACGTGGAACAA	GGGGACGCCCGGCGGGGCGGCGCCGGAGCGAACGGGCAACCGGGG
TGTTCCACGTGGAACAT	CAATCTTGAGTTCTCGGCCCAGACCGGACCGGG
TGTTCCACGTGGAACAC	TGGTCCGGGTCGAGGTCCGCCGTCGGCCGCG
TGTTCCACGTGGAACA

Protein	Signature genes	Signature genes Name	Protein_function
NC_014623.1\|WP_002613614.1\|10203254_10204307_-\|hypothetical-protein	unknown	unknown	unknown
NC_014623.1\|WP_037583234.1\|10192903_10193695_-\|ParA-family-protein	unknown	unknown	gnl\|CDD\|379293
NC_014623.1\|WP_002612635.1\|10188165_10189497_+\|ergothioneine-biosynthesis-protein-EgtB	unknown	unknown	gnl\|CDD\|274581
NC_014623.1\|WP_002612611.1\|10192007_10192892_-\|ParB/RepB/Spo0J-family-partition-protein	unknown	unknown	gnl\|CDD\|275105
NC_014623.1\|WP_148273537.1\|10197837_10199409_+\|sigma-54-interacting-transcriptional-regulator	unknown	unknown	gnl\|CDD\|226132
NC_014623.1\|WP_013378327.1\|10204771_10206595_-\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-enzyme-MnmG	unknown	unknown	gnl\|CDD\|235362
NC_014623.1\|WP_002612639.1\|10185313_10186708_+\|FAD-binding-protein	unknown	unknown	gnl\|CDD\|130740
NC_014623.1\|WP_041792290.1\|10199453_10203251_+\|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme	unknown	unknown	gnl\|CDD\|270916
NC_014623.1\|WP_002613627.1\|10208454_10208895_+\|hypothetical-protein	unknown	unknown	unknown
NC_014623.1\|WP_002613598.1\|10206821_10207571_-\|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein	unknown	unknown	gnl\|CDD\|378065
NC_014623.1\|WP_148273536.1\|10187298_10187820_-\|hypothetical-protein	unknown	unknown	unknown
NC_014623.1\|WP_013378321.1\|10191539_10192004_-\|bactofilin-BacM	unknown	unknown	gnl\|CDD\|377376
NC_014623.1\|WP_148273535.1\|10184648_10185170_-\|hypothetical-protein	unknown	unknown	unknown
NC_014623.1\|WP_002612647.1\|10195045_10196236_+\|hypothetical-protein	unknown	unknown	unknown
NC_014623.1\|WP_002612627.1\|10190976_10191540_-\|hypothetical-protein	unknown	unknown	unknown
NC_014623.1\|WP_013378317.1\|10186700_10187309_-\|RES-family-NAD+-phosphorylase	unknown	unknown	gnl\|CDD\|378053
NC_014623.1\|WP_002613619.1\|10207567_10208149_-\|hypothetical-protein	unknown	unknown	unknown
NC_014623.1\|WP_002612641.1\|10196199_10197639_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227511
NC_014623.1\|WP_013378322.1\|10194162_10194816_-\|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG	unknown	unknown	gnl\|CDD\|234637
NC_014623.1\|WP_002612612.1\|10189515_10190526_+\|L-histidine-N(alpha)-methyltransferase	unknown	unknown	gnl\|CDD\|378355

Protein	Function_ID	Function_description	E-value
NC_014623.1\|WP_037583234.1\|10192903_10193695_-\|ParA-family-protein	gnl\|CDD\|379293	pfam13614, AAA_31, AAA domain. This family includes a wide variety of AAA domains including some that have lost essential nucleotide binding residues in the P-loop.	3.59367e-91
NC_014623.1\|WP_002612635.1\|10188165_10189497_+\|ergothioneine-biosynthesis-protein-EgtB	gnl\|CDD\|274581	TIGR03440, egtB_TIGR03440, ergothioneine biosynthesis protein EgtB. Members of this family include EgtB, and enzyme of the ergothioneine biosynthesis, as found in numerous Actinobacteria. Characterized homologs to this family include a formylglycine-generating enzyme that serves as a maturase for an aerobic sulfatase (cf. the radical SAM enzymes that serve as anaerobic sulfatase maturases). [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	2.94888e-149
NC_014623.1\|WP_002612611.1\|10192007_10192892_-\|ParB/RepB/Spo0J-family-partition-protein	gnl\|CDD\|275105	TIGR04285, parB-like_partition_protein, nucleoid occlusion protein. This model describes nucleoid occlusion protein, a close homolog to ParB chromosome partitioning proteins including Spo0J in Bacillus subtilis. Its gene often is located near the gene for the Spo0J ortholog. This protein bind a specific DNA sequence and blocks cytokinesis from happening until chromosome segregation is complete.	5.60431e-80
NC_014623.1\|WP_148273537.1\|10197837_10199409_+\|sigma-54-interacting-transcriptional-regulator	gnl\|CDD\|226132	COG3604, FhlA, Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms].	2.46415e-107
NC_014623.1\|WP_013378327.1\|10204771_10206595_-\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-enzyme-MnmG	gnl\|CDD\|235362	PRK05192, PRK05192, tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG.	0
NC_014623.1\|WP_041792290.1\|10199453_10203251_+\|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.50216e-93
NC_014623.1\|WP_002612639.1\|10185313_10186708_+\|FAD-binding-protein	gnl\|CDD\|130740	TIGR01679, bact_FAD_ox, FAD-linked oxidoreductase. This model represents a family of bacterial oxidoreductases with covalently linked FAD, closely related to two different eukaryotic oxidases, L-gulonolactone oxidase (EC 1.1.3.8) from rat and D-arabinono-1,4-lactone oxidase (EC 1.1.3.37) from Saccharomyces cerevisiae.	1.5701e-48
NC_014623.1\|WP_013378321.1\|10191539_10192004_-\|bactofilin-BacM	gnl\|CDD\|377376	pfam04519, Bactofilin, Polymer-forming cytoskeletal. This is a family of bactofilins, a functionally diverse class of cytoskeletal, polymer-forming, proteins that is widely conserved among bacteria. In the example species C. crescentus, two bactofilins assemble into a membrane-associated laminar structure that shows cell-cycle-dependent polar localization and acts as a platform for the recruitment of a cell wall biosynthetic enzyme involved in polar morphogenesis. Bactofilins display distinct subcellular distributions and dynamics in different bacterial species, suggesting that they are versatile structural elements that have adopted a range of different cellular functions.	5.12606e-33
NC_014623.1\|WP_002613598.1\|10206821_10207571_-\|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein	gnl\|CDD\|378065	pfam08843, AbiEii, Nucleotidyl transferase AbiEii toxin, Type IV TA system. This family was recently identified as belonging to the nucleotidyltransferase superfamily. AbiEii is the cognate toxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.	8.87221e-15
NC_014623.1\|WP_013378317.1\|10186700_10187309_-\|RES-family-NAD+-phosphorylase	gnl\|CDD\|378053	pfam08808, RES, RES domain. This presumed domain contains 3 highly conserved polar groups that could form an active site. These are an arginine, glutamate and serine, hence the RES domain. The domain is found widely distributed in bacteria. The domain is about 150 residues in length.	1.61454e-12
NC_014623.1\|WP_002612641.1\|10196199_10197639_-\|hypothetical-protein	gnl\|CDD\|227511	COG5184, ATS1, Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton].	2.3897e-60
NC_014623.1\|WP_013378322.1\|10194162_10194816_-\|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG	gnl\|CDD\|234637	PRK00107, gidB, 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG.	3.96797e-58
NC_014623.1\|WP_002612612.1\|10189515_10190526_+\|L-histidine-N(alpha)-methyltransferase	gnl\|CDD\|378355	pfam10017, Methyltransf_33, Histidine-specific methyltransferase, SAM-dependent. The mycobacterial members of this family are expressed from part of the ergothioneine biosynthetic gene cluster. EGTD is the histidine methyltransferase that transfers three methyl groups to the alpha-amino moiety of histidine, in the first stage of the production of this histidine betaine derivative that carries a thiol group attached to the C2 atom of an imidazole ring.	3.1071e-151

>NC_014623.1|WP_037583234.1|10192903_10193695_-|ParA-family-protein
MGRIICISNQKGGVGKTTTAINLAASLASAERRTLLVDMDPQGNAGSGLGLKREMLQGTVYDAILGGRPMRELLHPTELRFLQVVPATPDLTGAEVELVNQERREFRLREALRPLAADYDYILIDCPPSLGLLTLNALVAADSVLIPLQCEYYALEGLSQLTHTVDLVQQGLNPGLKMEGILLTMFDSRANIANQVVEEARGYFKDQVFTAVVPRNVRLAECPSFGKPIILYDIKSKGCESYLALGREIMNREGHHPSKRHVA
>NC_014623.1|WP_002612611.1|10192007_10192892_-|ParB/RepB/Spo0J-family-partition-protein
MLNAGDKHKRALGRGLSALIPQAAPAPAASPEAAKAGVLKLPIESIHRDTAQPRRHFDEAKLAELTESIKAQGLLQPVLVRKDGQGYKLIAGERRWRAAQAAGLHELPAIVREVTEGQAFELALVENLQRSDLNPMEEAEGYHRLVEEFKLTQEQVSQRVGKERSTVANALRLLGLPDDVKALVAEGALSMGHARALLGVPRLPELQALATRVVEEKLSVRDTEKLVQQKRPQKKDTGKPSKQSPQVKALVEELQRLLGTKVRLAEKGQGKGTLEVDYFSYDDLDRLLKLLRKE
>NC_014623.1|WP_013378321.1|10191539_10192004_-|bactofilin-BacM
MALLGGKKEETLSSTISKPLFKREEESVSMRPGDIHTLLGKGSEFEGKLSFEGQVRIDGKFNGQIFTKDSLIIGDGARVQAEIHAGTVIIHGTVEGNVKATQLIELKQPGRVKGNLETPSLSMDRGVIFEGTLKMENLANSQKALPPPPGGDKK
>NC_014623.1|WP_002612627.1|10190976_10191540_-|hypothetical-protein
MRALGHSLGWAAVLALAVPAAGCQCGQKAAESPRPTAPVEGHGERPAAAKAGVKVPLPPGWSAIMAEDGSFQAGPPGQPVLRVDIRRGEGEKRPSSEALMASVREQFSQFEISLDQEEDEENLALLRLTIAPKLADGGVGMHAPTMLGAKRVGEDLFLCASLPGAETEEVRLSTEACREIQIQGAAR
>NC_014623.1|WP_002612612.1|10189515_10190526_+|L-histidine-N(alpha)-methyltransferase
MNGMDAPQADGPCRSLVSVEVHLHPDEARHALHAEALTGLCHRPKELSPKWLYDERGSQLFDDITRLPEYYPTRREREILLEHAHEVARLSGADTLIELGSGTSEKTRLLLGALRRTGRLRRFIPFDVSEHFLRRAAATLARDYPGLRVHAVVGDFERHLAYLPREGRRLVAFLGGTIGNFKPAARARFFQEVAHSLAPGDGLLLGTDLIKDRSRLFAAYNDSAGVTAEFNRNVLHVLNRELGANFDVNAFAHLAPFDEEQGWIEMRLISQRPQWVHLPALRRSAHFDAGEVLRTEVSCKFRPQQVESELFAAGLHLAAGWTDRARDFALSLAFKP
>NC_014623.1|WP_002612635.1|10188165_10189497_+|ergothioneine-biosynthesis-protein-EgtB
MPSPADRPDPARVTPQPWKSLAWQALEAARRRTLNMLAGLPEAELLRQHSPLMSPLVWDVAHVANYEEQWLLRALGGPALTDAAFDAVYDAFRHPRRTRSALPILSPEAAFAYAARVRDAVREHLEHLPEDAPLPLLQGGFVFGMVAQHEQQHAETLAATLQLMTTWEYRPAARPLPRPGAVPLHEVFIPGGPSLQGSHAPWAYDNERPPHPVHLAPFFLDAHPTTQGDYLVFVESGGYEDPRWWHPEGWAFIQAEGIRHPLFWARLGPHLWARRRFGFVEPLPRDEPVQHVCWYEADAYARWAGKRLPTEAEWERAATGGASSPPAFPWGNAPASPSHANLGGEAWAPAPVGAFPEGKSAEGVWGLLGDVWEWTASDFGAYPGFQAHPYREYSEVFFGPGHKVLRGGAWASAPVAVRNSFRNWDLPIRRQIFAGFRCARDAP
>NC_014623.1|WP_148273536.1|10187298_10187820_-|hypothetical-protein
MLELDQSSLESLLKELESSFEIVLRVLEQPEVLKMIQTVDPLALARVRGLRARQELLSAEGGSVGASDLAKLLEVTRQTVDDRRKAGKLLGVERGKHGYAYPIWQVSEEGQPLKGLEEVLAALRDHDTWSKLNFFLSKDPRLPEHKHPLDALRAGEVDKAVGIAKTYGEHGGL
>NC_014623.1|WP_013378317.1|10186700_10187309_-|RES-family-NAD+-phosphorylase
MVSSNPYTLQAPPVDLAKRPLPLVQAGGPWYRIHRAALGALYFGKAKAYRFDDPKQAYGVMYSGESFGCAFLETFGRVPQSRGRVSRKDLEDRSLTKLTRSQPLKLVDLANEGLGRLRMDASIFAVADYALPQEWSRAFHEHPEGPDGLSYRSRHDPSQLCAVVFERAQRGFATQLITASLMDHGFAAELGKTLDLYEFALI
>NC_014623.1|WP_002612639.1|10185313_10186708_+|FAD-binding-protein
MNFPASASASWVFIGSFHPKYSKGSASHKLPGVRHLTNWARNVEYSAARLHRPTSLDEVKALVASARAVRALGSGHSFNTLADTPGELISLEALAQEVVIDPSARTVTVSGGIRYGELGARLQAEGFALANLASLPHISVAGAIATATHGSGNTNRNLAAAVSGLTLVTARGETLALTRSSPDFAGAVVGLGALGLVTSVTLDIEPSFDVAVTVYEHLAWDTLLHHFDALMRAAYSVSLFTNWARDTVDQVWLKQRVDGTAGALPLPGQDFHGATPAPERRHPLPGAPAEACSEQLGIAGCWADRLPHFRLGFTPSRGEELQSEYILPRAHAAAAIEALRALAGRIAPLLQIAEIRTMAADDLWLSMNYRADSVGFHFTWKPLQPEVEALLPVIEEALAPFRARPHWGKLFHARASHLATLYEKWPAFIALAERLDPEHKFRNDFLARHVFGAGTQERRSEMIR
>NC_014623.1|WP_148273535.1|10184648_10185170_-|hypothetical-protein
MLATLNELMELEQRHVLMLITLLNFTAETGQLEQAEDFFIHQREYAPIAIAHFESREEAEAWLNGAVEPPSPARILIGDEYHQLGYTREDKTRGMCRDYAIEPVTESMTVRGIPSPVLSFATRTEAEAWLMKHPADPYDFVATAGAYWFAVHHRRLNRHLGRGTGEATHRHWL
>NC_014623.1|WP_013378322.1|10194162_10194816_-|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG
MDNARFVDQLQRGGEALGLSLGEGVAPGLQRLMAELLKWNAKVNLTAITAPEEVLEKHFLDSLAVLPEVEGAASLLDLGAGAGFPGLPLKLARPALAVTLVDAVGKKVGFLKAAIAALGLKEARGLHLRAEGDPEREGIPRAELLIARAFMDLPDWLALAPAYVRPGGRVVAMLGKAQPESELAARASERGLRVVSSRQYRLPFSGAERQVAVFSQA
>NC_014623.1|WP_002612647.1|10195045_10196236_+|hypothetical-protein
MPSVAQQVEAKLSCHLSEALVTPLEQREVVSLLRRDSHLAATLGELHQRGALKVLVRRVDAPEPRRSLMDLLAARADTAQAGVIRDELAAIDLSAPPLPLLHKDARPQEGARGAELTEELWQVRFHLLRLGVPAHGQRFDESPYRRVIPLDSREPFTGQGATGIRPDARTLPRSDKWSRWRQVPPPPTLAPGPSGDWASYLAKLGAKDRLLQAKLVLRRPLTTLMPTVWGPLPPSRAELISVAARQYGLEPALVAALLLAGQRAQSAHEEARHYALATGGEPHCLLGLGQVAVSVATRDGLLSDVLSAEALRHASPLHLARLLTDDALNIMAAAKALRLLAETRAPGPRFEHLHAGHIRALATAYTRLAQDGPQATAWGDFVYEAYLDMKATRAFP
>NC_014623.1|WP_002612641.1|10196199_10197639_-|hypothetical-protein
MPKYRGRDSQVKTRRTRKLLPWMGFCLLAGCGLADSPSGRGTPAASTPQVLLPKGAASRRASPVQALGLGGMAALAACCVHGMALRASGGGWTLRGLGEGAGGGEASKHRATPAQAADQRGVRAVAGGYQYSLALHADGTVWACGSNSAGQLGNGTTAARSAPRPVPGLSRAVAVAAGGSHALALCADGTVWAWGNNGYGQLGNGSTAHRATPVQVPGLQGVVAVAGGYMHSLALCADGTVWAWGFNDYGQLGNGTTVHSPTPVPVPGLSQVVSVAAGGFHSLALCADGTVWAWGNNGFGQLGEAVSTQRTKPGRVEGLREVVAVAGGFYHSLAVRAGGSLWSWGNNYSGQLGNGSFSSSARPAPVQGLGAVTSVAAGGMHSVAVQADGTVWAWGRNEEGQLGHERAPERATPVRVPGLQGEVAVAAGFYHSLSVQAGGSLWAWGLNDFGQLGDSEAPLMPVPAPGWAQGKARVAFMSR
>NC_014623.1|WP_148273537.1|10197837_10199409_+|sigma-54-interacting-transcriptional-regulator
MYAWLTLWHVPTAPNDVTQDGERDRLQQERDFYRSLLELGARDSLEPFLEEALALSASMSGAKRGYIELQEDQRPEGPPRFWMAHGCYDEEVEEIRATFSRGVIAEALATGQTIVTESALRDPRFGSRNSVRRNRSEAVLCAPIGASPTLGVVYLQDRHQPGPFSEEDRKRLEIFARYLATFAERLLTLHRQREAADATQPFRGRLRAEGVIGRSASLARVLEQVSLVAPLDVNVLLTGPSGTGKTQLARVIHDNSPRASHPFLELNCAALPETLVESELFGVLPGAHSTASRKVEGKVAAAEGGTLFLDEVGDLPLTSQAKLLQLLQSREYYPLGGTRPQRADVRILAATNVDLRAAVARKTFREDLLYRLEVLPVRLPSLAERPEDLLELAEYFCASACEQHHLPRLRLSPGALRAVEAAEWPGNVRELAHKVQAAVIRASGEGVARIERRHLFPEAKGEGARGPEPLTFQEATRRFQEQLLLKTLEDTAWNITEAASKLELSRSHIYNLIAAFGLERRKP
>NC_014623.1|WP_041792290.1|10199453_10203251_+|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme
MPRPLPKPGWSPPETMGEYRLLRLLGRGGMGQVYLAEDTLLERTVALKLIASVRPDEAARKRFHAEARAIARLSHPNVVTVHRVGEVDGRPYLVTEFIRGQTLGELARPIAPERVLTIALGLARGLAAAHRQGVLHRDIKPANAMLTEDGEVKLLDFGLAKLLEGPRMAPLEAPARAAPPVPALRELSDAEDLMGTPLYMAPEALRGEPSTRRSDLYSLGAVLYELCAGIAPRQTLDEQMPFEAWASAEPTPLPERVKDVDPRFAALVTRCLHTEPERRFASADELCAALSELKREREQPPEGEVPEGNPYRGLRPFEAEHRAFFFGRSMEVEAVLERLRAEPLVLVTGDSGVGKSSLCRAGVLPRVAEGALGPGRHYRTLSLIPGARPLAALASATESLLEKGEALPSELLRTDPRAFVRELLRTQGRQAGTLLFVDQLEELFTIGAPEEAAPFAEGVVRLSDLPGVRVLLTVRGDFFTRLASLPGLGEQVARALYLLRPLSAEAARGAIVGPAQSQGIHFESEALVSTLAESAVSSAGGLPLLQFAMAELWEARDEARRCIPASALEALGGVDGALSRHADRVLAGLQPEQRRAARALLPRLVSPEGTGARRSGAELDAGEPATQGALDALVKGRLVVARETDGETTYEVAHEALLRGWGTLRSWLVTEGEKRPVRERLEAAAAEWARLERTREALWSERLLLETQGVDRDALSPRGTEFLDASHSATRRRRWRQRALLMAVPLALVLALGGVRLQAQWTRARKVAWYEAQATGLTERGLARKQAAEALRLRAHGLFEAVGGGTVEETAARRESAERAWEEALTALHEADDALDEAGQSLEAALVVDLSNDRVRGRIVDVLIERLELAESFHQQNRLRELTRRIRAYDSDGLRQERLQAPPELSLTSSPSGAEVVLERYQEDAKGYRTLSGAQRLGRTPLAKLVLEEGPGSYRLTLHAPGHVPVQAPVLLGRGEHLPLHVPLPAEGAVPEGFVYVPPGRFLVGSAEPEDMRRGLLNAPPLHESQTGGFLVARTEVTFGQWLEFLRDESPGGLAQGRRPYSDVRQWGVELTPAASGRWRLTFQLNKRSLSASEGEPLLFPGRAVRREQDWSRLPVSGISFEDARAYLAWLNRTGRVPGARFCHEREWERAARGADGRAFPHGNRLEAEDANFDQTYGRKTDAFGPDEVGSHPASASPFGLLDMTGNVYEFTLSMGAREEIAIRGGSWYFDRVSVLAANRTFVEPRTRDIGTGMRVCADAPAVGP
>NC_014623.1|WP_002613614.1|10203254_10204307_-|hypothetical-protein
MSLPDLSAIVSMWVLAVLSFLSSGSPPAPDEAPLARERPVIEDPRCPFGVRHSQFQFRAVLDSRPQSPLYRGGCLEHVVFLKGSLRDGVFLGGNQADAFFRRNLTTGSRPSAPVKLVRKSPYTLGKVNASLTPYEISYEGTNLCADSMYQPGPEGELAPEPPGGTALLIPGYWDEADGVWRAQYKGESVFTAACYDGTVAKCAHWGYVPWGRYAGKSLQPYHQACVPAARAEYDHVKAYTCANTAIDIFDNLGLLRRREGSAFSFESRWNQHGLTCVARPRWKGCESDLAGVLGACPEPVLGQSWGGDLIGIRSSADRGLQNFDAVSSASMPFLCPVEGVENVGCEFQPD
>NC_014623.1|WP_013378327.1|10204771_10206595_-|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-enzyme-MnmG
MKHRYDVIVVGLGHAGCEAALACSRLGLSTLGLTLKRDRAAVMSCNPAVGGTAKGHLVRELDALGGEMGRAADLSGTHFKTLNASKGPAVQATRILCDRDAYARTVQAALFSQPHLTVHEAEVSSLAVEDGHVAGVVLGDGSQVQARAVLLTTGTFLQALMHVGEKKEVGGRLGDEAARGLSLSLRSLGFTLGRFKTGTPARLRRDSIDWDAVEPQPTDAPPRPFSWRTRQDIASGVPFPLQPSVTCGITFTTEATHRLLRDNLHRSPLFQGDIVGRGPRYCPSLEDKVVRFAARERHQVFLEPEGPDSPLVYPAGLSTSMPADVQLDFLRSIPGLAQVEVVRFGYAVEYDYAPPTQLSSTLETKAVRGLFFAGQLNGTSGYEEAAFQGLYAGLNAALQVKGEPPLLLGREEAHGAVLVDELVTKGVDEPFRMFTSRSEHRLKLREGNAEARLARHGHRVGLLPREALERVEARVHAVQREVARLKRSGLGARLKRPEVTYASLAAEAREWPEVPPEVAEEVEVEVKYEGYIAQAERAAAREADAWDGWVIPAGFRFAEVRGLSSEAVEKLSAHRPGTVGQVRRIPGLTPAALSLVLVALKRERARD
>NC_014623.1|WP_002613598.1|10206821_10207571_-|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein
MSFIHADPDFDDLLRIVADNRKLSLALVEKDYWVTHTLWALHEEGFDVWFKGGTSLSKGFSLIHRFSEDLDLKIEPGRVRLSPVSNWKSDGTQATNARRAYFEALPSFIRVPGTTVELDRNTPDDRWRSGNVRVLYPARHLGALADVLRPFVLLEVGHARVTPFMPRDMSSFVHDHLATTGHLDDYDDNRPKGVRCVHPLVTLLEKLDALQRKVPREDIEPASFVRHYEDAARIIAAEPNLPPFRTSPM
>NC_014623.1|WP_002613619.1|10207567_10208149_-|hypothetical-protein
MASKALPPLEAGCVYRTRDFEPWSTNPPRLAKRLVERGVLVRVAQGLFACPKRSKFGVVPPGDDALMKAFLEGSPFVFTGPERWNALGLGATALFAAPLVYNIKRSGVFELGGRRFELRRVPFPQVPSPEWFVVDLFENAERAGTSRTELAGALSRALARGSFDRERLGAMAQRYGTKATRVLVYSALQDVAV
>NC_014623.1|WP_002613627.1|10208454_10208895_+|hypothetical-protein
MALKPSGQILISGVQHPPGAVHTQKASDLAAPEDRGHARGQASAQEAAEKLSGMAEQRQAVRVFEDIADKIILQLAPLFEEAQKRGHLNLEAVAHELASALSGRISADFLVARKLDPAKLARAFREAHPLPRAQLSVAGRWCFSTA

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_014623_6	6.1\|8408572\|29\|NC_014623\|CRISPRCasFinder	8408572-8408600	29	NC_014623.1	9637399-9637427	1	0.966
NC_014623_7	7.1\|9278871\|36\|NC_014623\|CRISPRCasFinder	9278871-9278906	36	NC_014623.1	9637399-9637434	1	0.972

1. spacer 6.1|8408572|29|NC_014623|CRISPRCasFinder matches to position: 9637399-9637427, mismatch: 1, identity: 0.966

tgtgacgacccctttggctcctgcgggga	CRISPR spacer
tgtgacgacccctttggctcctgcggtga	Protospacer
************************** **

2. spacer 7.1|9278871|36|NC_014623|CRISPRCasFinder matches to position: 9637399-9637434, mismatch: 1, identity: 0.972

tgtgacgacccctttggctcctgcggggagggtgag	CRISPR spacer
tgtgacgacccctttggctcctgcggtgagggtgag	Protospacer
************************** *********

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_014623_9	9.3\|10194022\|31\|NC_014623\|PILER-CR	10194022-10194052	31	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	107405-107435	6	0.806
NC_014623_9	9.3\|10194022\|31\|NC_014623\|PILER-CR	10194022-10194052	31	NC_009468	Acidiphilium cryptum JF-5 plasmid pACRY02, complete sequence	62448-62478	6	0.806
NC_014623_9	9.3\|10194022\|31\|NC_014623\|PILER-CR	10194022-10194052	31	LN997843	Streptomyces reticuli genome assembly TUE45, plasmid : II	73363-73393	7	0.774
NC_014623_9	9.3\|10194022\|31\|NC_014623\|PILER-CR	10194022-10194052	31	NZ_CP007516	Rubrobacter radiotolerans strain RSPS-4 plasmid 2, complete sequence	115504-115534	8	0.742
NC_014623_9	9.3\|10194022\|31\|NC_014623\|PILER-CR	10194022-10194052	31	NZ_CP009453	Sphingopyxis sp. 113P3 plasmid unnamed, complete sequence	103706-103736	8	0.742
NC_014623_9	9.3\|10194022\|31\|NC_014623\|PILER-CR	10194022-10194052	31	NC_010510	Methylobacterium radiotolerans JCM 2831 plasmid pMRAD01, complete sequence	436374-436404	9	0.71
NC_014623_9	9.3\|10194022\|31\|NC_014623\|PILER-CR	10194022-10194052	31	NZ_CP036405	Komagataeibacter saccharivorans strain JH1 plasmid p221732, complete sequence	146992-147022	10	0.677

1. spacer 9.3|10194022|31|NC_014623|PILER-CR matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 6, identity: 0.806

ctggtccgggtcgaggtccgccgtcggccgc	CRISPR spacer
gccgtccgggtcgaggtcggccgtcggaccc	Protospacer
 . *************** ******** * *

2. spacer 9.3|10194022|31|NC_014623|PILER-CR matches to NC_009468 (Acidiphilium cryptum JF-5 plasmid pACRY02, complete sequence) position: , mismatch: 6, identity: 0.806

ctggtccgggtcgaggtccgccgtcggccgc	CRISPR spacer
tggttccgggtcgaggtccgcggccggccgg	Protospacer
. * ***************** *.******

3. spacer 9.3|10194022|31|NC_014623|PILER-CR matches to LN997843 (Streptomyces reticuli genome assembly TUE45, plasmid : II) position: , mismatch: 7, identity: 0.774

ctggtccgggtcgaggtccgccgtcggccgc	CRISPR spacer
cacccccgggtcgacgtccgtcgtcggccgg	Protospacer
*   .********* *****.*********

4. spacer 9.3|10194022|31|NC_014623|PILER-CR matches to NZ_CP007516 (Rubrobacter radiotolerans strain RSPS-4 plasmid 2, complete sequence) position: , mismatch: 8, identity: 0.742

ctggtccgggtcgaggtccgccgtcggccgc	CRISPR spacer
gttctccgggtcgaggttcgcggtcggctcg	Protospacer
 *  *************.*** ******.

5. spacer 9.3|10194022|31|NC_014623|PILER-CR matches to NZ_CP009453 (Sphingopyxis sp. 113P3 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.742

ctggtccgggtcgaggtccgccgtcggccgc	CRISPR spacer
ctggtccgggtcgaggttcgacgcccgaaca	Protospacer
*****************.** **.* *

6. spacer 9.3|10194022|31|NC_014623|PILER-CR matches to NC_010510 (Methylobacterium radiotolerans JCM 2831 plasmid pMRAD01, complete sequence) position: , mismatch: 9, identity: 0.71

ctggtccgggtcgaggtccgccgtcggccgc	CRISPR spacer
cgaagccgggtcgaggttcgcggtcggctcg	Protospacer
* .. ************.*** ******.

7. spacer 9.3|10194022|31|NC_014623|PILER-CR matches to NZ_CP036405 (Komagataeibacter saccharivorans strain JH1 plasmid p221732, complete sequence) position: , mismatch: 10, identity: 0.677

ctggtccgggtcgaggtccgccgtcggccgc	CRISPR spacer
ggcttccgggtcaagggccgccgtcggttca	Protospacer
    ********.*** **********..

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

2924983 : 3075254

115

Pandoravirus(23.08%)

transposase,plate,tail

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_148273323.1\|2924983_2925788_+\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_002615208.1\|2926125_2926905_+	crotonase/enoyl-CoA hydratase family protein	NA	NA	NA	NA
WP_002615210.1\|2926926_2927514_+	hypothetical protein	NA	NA	NA	NA
WP_075298501.1\|2927858_2929040_-	ROK family protein	NA	NA	NA	NA
WP_002615196.1\|2929170_2930487_+	xylose isomerase	NA	NA	NA	NA
WP_002615191.1\|2930859_2931792_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_002615201.1\|2931870_2932452_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_002615202.1\|2932571_2934176_-	discoidin domain-containing protein	NA	NA	NA	NA
WP_013375189.1\|2934616_2934835_+	hypothetical protein	NA	NA	NA	NA
WP_037583672.1\|2935763_2937203_-	serine/threonine protein kinase	NA	NA	NA	NA
WP_002615215.1\|2937259_2937913_-	glutathione S-transferase family protein	NA	NA	NA	NA
WP_002615187.1\|2938014_2938818_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_002615193.1\|2939019_2940330_+	VCBS repeat-containing protein	NA	NA	NA	NA
WP_037583671.1\|2940821_2941055_+	hypothetical protein	NA	NA	NA	NA
WP_002615207.1\|2941041_2941425_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_013375193.1\|2941475_2941820_+	nuclear transport factor 2 family protein	NA	NA	NA	NA
WP_013375195.1\|2942280_2943207_+	AraC family transcriptional regulator	NA	NA	NA	NA
WP_013375196.1\|2943279_2944332_+	NAD(P)-dependent alcohol dehydrogenase	A0A2K9L339	Tupanvirus	1.0e-74	41.8
WP_013375197.1\|2944328_2945069_+	NAD(P)-binding domain-containing protein	NA	NA	NA	NA
WP_002615204.1\|2945375_2945954_+	pyridoxamine 5'-phosphate oxidase family protein	NA	NA	NA	NA
WP_037583670.1\|2946359_2946731_+	hypothetical protein	NA	NA	NA	NA
WP_013375199.1\|2946848_2947031_+	hypothetical protein	NA	NA	NA	NA
WP_002615199.1\|2947516_2948413_+	transcriptional regulator	NA	NA	NA	NA
WP_037583668.1\|2948610_2949006_+	hypothetical protein	NA	NA	NA	NA
WP_157601342.1\|2949053_2949344_+	IS66 family insertion sequence element accessory protein TnpB	S5VXZ8	Leptospira_phage	9.8e-07	35.4
WP_013375203.1\|2949388_2951050_+\|transposase	IS66 family transposase	A0A0P0ZBS5	Stx2-converting_phage	8.8e-60	36.4
WP_002617281.1\|2953390_2954032_-	hypothetical protein	NA	NA	NA	NA
WP_013375205.1\|2954183_2955443_+	GAF domain-containing sensor histidine kinase	W8CYF6	Bacillus_phage	2.6e-11	25.5
WP_086016074.1\|2956397_2956775_+	AI-2E family transporter	NA	NA	NA	NA
WP_037583987.1\|2956771_2957149_+	nuclear transport factor 2 family protein	NA	NA	NA	NA
WP_037583993.1\|2957872_2958211_-	antibiotic biosynthesis monooxygenase	NA	NA	NA	NA
WP_002617283.1\|2959394_2959949_+	dihydrofolate reductase family protein	NA	NA	NA	NA
WP_013375213.1\|2962329_2963730_+	hypothetical protein	NA	NA	NA	NA
WP_013375214.1\|2963746_2963980_-	hypothetical protein	NA	NA	NA	NA
WP_002617279.1\|2964054_2965197_+	DUF1016 family protein	A0A0U2BZN7	Salmonella_phage	1.2e-52	64.1
WP_002617286.1\|2965296_2965485_+	hypothetical protein	NA	NA	NA	NA
WP_013375215.1\|2965468_2966671_+	recombinase family protein	A0A2K9V3K8	Faecalibacterium_phage	3.9e-17	27.7
WP_002617285.1\|2967306_2968080_+	hypothetical protein	NA	NA	NA	NA
WP_002617278.1\|2968124_2969633_+	SAVED domain-containing protein	NA	NA	NA	NA
WP_002617284.1\|2969644_2970784_+	hypothetical protein	NA	NA	NA	NA
WP_002617282.1\|2970780_2972643_+	ThiF family adenylyltransferase	S4VW33	Pandoravirus	6.7e-08	38.1
WP_013375216.1\|2972639_2973152_+	Mov34/MPN/PAD-1 family protein	NA	NA	NA	NA
WP_013375218.1\|2974156_2974540_+\|transposase	transposase zinc-binding domain-containing protein	NA	NA	NA	NA
WP_002619913.1\|2974623_2976900_-	hypothetical protein	NA	NA	NA	NA
WP_013375219.1\|2976896_2980415_-	AAA family ATPase	NA	NA	NA	NA
WP_187323591.1\|2980686_2980842_+	hypothetical protein	NA	NA	NA	NA
WP_002620552.1\|2981460_2982234_+	hypothetical protein	NA	NA	NA	NA
WP_013375222.1\|2982760_2983573_+	hypothetical protein	NA	NA	NA	NA
WP_081465908.1\|2984057_2985395_+\|transposase	IS66 family transposase	NA	NA	NA	NA
WP_013375225.1\|2985499_2985853_+	hypothetical protein	NA	NA	NA	NA
WP_037583660.1\|2985849_2987184_+	hypothetical protein	NA	NA	NA	NA
WP_013375228.1\|2988157_2989771_+\|transposase	IS1182-like element ISStau7 family transposase	NA	NA	NA	NA
WP_081465909.1\|2989674_2990106_+	DUF2381 family protein	NA	NA	NA	NA
WP_002615160.1\|2990102_2991848_+	serine/threonine protein kinase	S4VV57	Pandoravirus	5.7e-09	26.4
WP_013375230.1\|2992008_2993145_+	protein kinase	NA	NA	NA	NA
WP_081465998.1\|2993467_2994799_+\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_002615176.1\|2994939_2995248_+	hypothetical protein	NA	NA	NA	NA
WP_013375232.1\|2995232_2995820_-	hypothetical protein	NA	NA	NA	NA
WP_013375233.1\|2995821_2997120_-	AHH domain-containing protein	NA	NA	NA	NA
WP_002615157.1\|2997608_2998697_-\|transposase	IS701 family transposase	NA	NA	NA	NA
WP_002615168.1\|2998892_3000224_-	DUF4417 domain-containing protein	NA	NA	NA	NA
WP_013375235.1\|3000422_3001040_-	hypothetical protein	NA	NA	NA	NA
WP_013375237.1\|3002898_3003363_-	hypothetical protein	NA	NA	NA	NA
WP_013375238.1\|3003393_3004659_-	DNA cytosine methyltransferase	A7XXH6	Thermus_virus	3.4e-27	31.7
WP_002615174.1\|3004655_3005657_-	PD-(D/E)XK motif protein	NA	NA	NA	NA
WP_002615180.1\|3005656_3007825_-	hypothetical protein	NA	NA	NA	NA
WP_157601341.1\|3007828_3010267_-	ATP-binding protein	NA	NA	NA	NA
WP_002615177.1\|3010595_3010742_-	hypothetical protein	NA	NA	NA	NA
WP_002615158.1\|3010948_3012973_-	hypothetical protein	NA	NA	NA	NA
WP_013375241.1\|3012969_3015588_-	hypothetical protein	NA	NA	NA	NA
WP_002615178.1\|3015602_3017087_-	hypothetical protein	NA	NA	NA	NA
WP_002615169.1\|3017070_3020385_-	AAA family ATPase	NA	NA	NA	NA
WP_013375243.1\|3020381_3021710_-	hypothetical protein	NA	NA	NA	NA
WP_148273324.1\|3021706_3022390_-	protein phosphatase 2C domain-containing protein	NA	NA	NA	NA
WP_002615175.1\|3022401_3023058_-	VWA domain-containing protein	NA	NA	NA	NA
WP_013375245.1\|3023459_3023783_+	hypothetical protein	NA	NA	NA	NA
WP_013375246.1\|3023811_3025599_+	sigma 54-interacting transcriptional regulator	NA	NA	NA	NA
WP_013375247.1\|3026272_3026845_+	hypothetical protein	NA	NA	NA	NA
WP_037584628.1\|3027566_3028109_+	DUF2924 domain-containing protein	K4I3X1	Acidithiobacillus_phage	2.9e-12	31.7
WP_013375249.1\|3028105_3028306_+	hypothetical protein	NA	NA	NA	NA
WP_041791806.1\|3028302_3029856_+	recombinase family protein	K4ICM1	Acidithiobacillus_phage	6.1e-71	44.6
WP_002619295.1\|3029852_3030275_+	hypothetical protein	NA	NA	NA	NA
WP_002619299.1\|3030456_3031902_+	hypothetical protein	NA	NA	NA	NA
WP_041791809.1\|3031891_3034093_+	hypothetical protein	NA	NA	NA	NA
WP_002619301.1\|3034089_3035424_+	hypothetical protein	NA	NA	NA	NA
WP_075298736.1\|3035756_3036665_+	DUF2381 family protein	NA	NA	NA	NA
WP_002619302.1\|3036621_3038367_+	serine/threonine protein kinase	S4VV57	Pandoravirus	2.3e-10	27.4
WP_187323627.1\|3039054_3040704_-\|transposase	IS66 family transposase	A0A0P0ZEB3	Stx2-converting_phage	5.0e-39	28.5
WP_013375256.1\|3040849_3041191_-	IS66 family insertion sequence element accessory protein TnpB	NA	NA	NA	NA
WP_002614171.1\|3041190_3041538_-	hypothetical protein	NA	NA	NA	NA
WP_075298713.1\|3041584_3041860_+	protein kinase	NA	NA	NA	NA
WP_013375232.1\|3041844_3042432_-	hypothetical protein	NA	NA	NA	NA
WP_002618765.1\|3042433_3043732_-	AHH domain-containing protein	NA	NA	NA	NA
WP_002618769.1\|3043861_3044041_+	hypothetical protein	NA	NA	NA	NA
WP_148273325.1\|3044202_3045063_-	hypothetical protein	NA	NA	NA	NA
WP_081465910.1\|3045283_3045586_-\|transposase	transposase	NA	NA	NA	NA
WP_187323592.1\|3045589_3046753_-\|transposase	transposase	NA	NA	NA	NA
WP_187323593.1\|3047420_3051701_-	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_002618764.1\|3052208_3053042_-	hypothetical protein	NA	NA	NA	NA
WP_013375261.1\|3053096_3053714_-\|transposase	transposase zinc-binding domain-containing protein	NA	NA	NA	NA
WP_002620483.1\|3055055_3055307_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_148273590.1\|3055284_3056112_+\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_013375263.1\|3056178_3057429_+	hypothetical protein	NA	NA	NA	NA
WP_013375265.1\|3057754_3059521_+	DUF4365 domain-containing protein	NA	NA	NA	NA
WP_002616278.1\|3059626_3059920_+	hypothetical protein	NA	NA	NA	NA
WP_002616288.1\|3061766_3066173_-	TIR domain-containing protein	NA	NA	NA	NA
WP_002616266.1\|3066443_3067238_-	ribbon-helix-helix protein, CopG family	NA	NA	NA	NA
WP_002616275.1\|3067473_3067770_-	hypothetical protein	NA	NA	NA	NA
WP_013375269.1\|3067899_3068337_-	hypothetical protein	NA	NA	NA	NA
WP_002616290.1\|3068344_3070255_-	hypothetical protein	NA	NA	NA	NA
WP_002616283.1\|3070742_3072080_-\|tail	tail protein	NA	NA	NA	NA
WP_002616271.1\|3072089_3072485_-	hypothetical protein	NA	NA	NA	NA
WP_002616270.1\|3072489_3073185_-	hypothetical protein	NA	NA	NA	NA
WP_002616279.1\|3073192_3073723_-	hypothetical protein	NA	NA	NA	NA
WP_187323594.1\|3073724_3075254_-\|plate	baseplate J/gp47 family protein	NA	NA	NA	NA

DBSCAN-SWA_2

3080779 : 3111380

Pseudomonas_phage(33.33%)

portal,terminase,capsid,tail,integrase

attL 3091063:3091078|attR 3114184:3114199

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013375278.1\|3080779_3083464_-\|tail	phage tail tape measure protein	A0A2H4J055	uncultured_Caudovirales_phage	4.8e-23	29.8
WP_002616267.1\|3083467_3083659_-	hypothetical protein	NA	NA	NA	NA
WP_002616281.1\|3083655_3084429_-	hypothetical protein	NA	NA	NA	NA
WP_013375279.1\|3084520_3086659_-	DUF262 domain-containing protein	NA	NA	NA	NA
WP_148273327.1\|3086748_3088557_-	group II intron reverse transcriptase/maturase	A0A0U4J920	Pseudomonas_phage	2.7e-38	31.9
WP_002614562.1\|3088972_3089440_-\|tail	phage tail protein	NA	NA	NA	NA
WP_002614618.1\|3089451_3090102_-\|tail	tail protein	J9PVC2	Bacillus_phage	3.7e-14	31.1
WP_013375282.1\|3090133_3091669_-	heme-binding protein	NA	NA	NA	NA
3091063:3091078	attL	NA	NA	NA	NA
WP_002614560.1\|3091665_3091995_-	hypothetical protein	NA	NA	NA	NA
WP_002614588.1\|3091991_3092894_-	IPT/TIG domain-containing protein	NA	NA	NA	NA
WP_013375283.1\|3092893_3093499_-	hypothetical protein	NA	NA	NA	NA
WP_002614568.1\|3093506_3094151_-	hypothetical protein	NA	NA	NA	NA
WP_187323628.1\|3094147_3094378_-	hypothetical protein	NA	NA	NA	NA
WP_002614561.1\|3094452_3094977_-	hypothetical protein	NA	NA	NA	NA
WP_013375284.1\|3094976_3095615_-	hypothetical protein	NA	NA	NA	NA
WP_002614590.1\|3095616_3095994_-	hypothetical protein	NA	NA	NA	NA
WP_013375286.1\|3096002_3096230_-	hypothetical protein	NA	NA	NA	NA
WP_002614558.1\|3096331_3096943_-\|capsid	phage major capsid protein	A0A1B1P7E3	Bacillus_phage	7.3e-36	42.3
WP_002614551.1\|3096988_3097678_-	hypothetical protein	NA	NA	NA	NA
WP_002614569.1\|3097674_3099027_-	DNA adenine methylase	L7TJ93	Halovirus	1.2e-17	30.7
WP_002614554.1\|3099019_3099205_-	hypothetical protein	NA	NA	NA	NA
WP_002614621.1\|3099260_3100340_-	hypothetical protein	NA	NA	NA	NA
WP_002614597.1\|3100320_3100602_-	hypothetical protein	NA	NA	NA	NA
WP_037583547.1\|3100598_3102623_-\|portal	phage portal protein	A0A0U3E050	Pseudomonas_phage	4.8e-52	30.0
WP_002614556.1\|3103006_3103939_-	hypothetical protein	NA	NA	NA	NA
WP_002614619.1\|3104263_3105166_+	hypothetical protein	NA	NA	NA	NA
WP_013375291.1\|3105325_3106591_+	hypothetical protein	NA	NA	NA	NA
WP_002614578.1\|3107506_3109156_+	SGNH/GDSL hydrolase family protein	NA	NA	NA	NA
WP_187323629.1\|3109250_3109793_-\|terminase	terminase	NA	NA	NA	NA
WP_002614594.1\|3110765_3111380_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
3114184:3114199	attR	NA	NA	NA	NA

DBSCAN-SWA_3

3174142 : 3198521

Bacillus_phage(66.67%)

plate,capsid,tail

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002617562.1\|3174142_3175492_-\|tail	tail protein	NA	NA	NA	NA
WP_002617545.1\|3175501_3175897_-	hypothetical protein	NA	NA	NA	NA
WP_002617552.1\|3175901_3176597_-	hypothetical protein	NA	NA	NA	NA
WP_002617551.1\|3176604_3177138_-	hypothetical protein	NA	NA	NA	NA
WP_013375329.1\|3177139_3178669_-\|plate	baseplate J/gp47 family protein	NA	NA	NA	NA
WP_037584062.1\|3179058_3180285_+	hypothetical protein	NA	NA	NA	NA
WP_013375331.1\|3180310_3180691_-	GPW/gp25 family protein	NA	NA	NA	NA
WP_002617544.1\|3180698_3181373_-	hypothetical protein	NA	NA	NA	NA
WP_002617542.1\|3181381_3181960_-	hypothetical protein	NA	NA	NA	NA
WP_013375332.1\|3181971_3183255_-	phage late control D family protein	NA	NA	NA	NA
WP_013375333.1\|3183251_3183593_-	LysM peptidoglycan-binding domain-containing protein	NA	NA	NA	NA
WP_002617565.1\|3183592_3184105_-	hypothetical protein	NA	NA	NA	NA
WP_013375334.1\|3184119_3186804_-\|tail	phage tail tape measure protein	A0A2H4J055	uncultured_Caudovirales_phage	2.8e-23	30.1
WP_013375335.1\|3186995_3187769_-	hypothetical protein	NA	NA	NA	NA
WP_013375337.1\|3190551_3191019_-\|tail	phage tail protein	NA	NA	NA	NA
WP_013375338.1\|3191030_3193247_-\|tail	tail protein	J9PVC2	Bacillus_phage	4.7e-40	32.2
WP_013375339.1\|3193243_3193576_-	hypothetical protein	NA	NA	NA	NA
WP_013375340.1\|3193572_3194475_-	IPT/TIG domain-containing protein	NA	NA	NA	NA
WP_013375341.1\|3194474_3195077_-	hypothetical protein	NA	NA	NA	NA
WP_013375342.1\|3195084_3195726_-	hypothetical protein	NA	NA	NA	NA
WP_187323630.1\|3195722_3195953_-	hypothetical protein	NA	NA	NA	NA
WP_013375344.1\|3196027_3196552_-	hypothetical protein	NA	NA	NA	NA
WP_013375345.1\|3196551_3197190_-	hypothetical protein	NA	NA	NA	NA
WP_013375346.1\|3197191_3197569_-	hypothetical protein	NA	NA	NA	NA
WP_013375347.1\|3197660_3198521_-\|capsid	phage major capsid protein	A0A1B1P7E3	Bacillus_phage	8.7e-35	42.3

DBSCAN-SWA_4

6658598 : 6694326

Pandoravirus(16.67%)

transposase,integrase

attL 6687456:6687482|attR 6694384:6694410

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002617905.1\|6658598_6659408_+\|transposase	IS5-like element ISStau10 family transposase	NA	NA	NA	NA
WP_002617901.1\|6659430_6660225_-\|transposase	IS5-like element ISStau9 family transposase	NA	NA	NA	NA
WP_002617903.1\|6660382_6662767_+	SEC-C domain-containing protein	NA	NA	NA	NA
WP_081466015.1\|6663006_6664338_+\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_002617914.1\|6665029_6666382_-	hypothetical protein	NA	NA	NA	NA
WP_037584155.1\|6666510_6667125_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_037584152.1\|6667243_6667468_+	hypothetical protein	NA	NA	NA	NA
WP_013376761.1\|6667553_6669860_-	glycoside hydrolase family 3 C-terminal domain-containing protein	NA	NA	NA	NA
WP_013376762.1\|6669893_6671267_-	beta-glucosidase	A0A0B5JD41	Pandoravirus	1.6e-67	33.7
WP_002617898.1\|6671314_6672367_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	2.4e-18	32.7
WP_041792076.1\|6672363_6673338_-	ABC transporter ATP-binding protein	W6JKT0	Anomala_cuprea_entomopoxvirus	6.4e-10	24.9
WP_002618659.1\|6673327_6674272_-	ABC transporter permease	NA	NA	NA	NA
WP_013376765.1\|6674295_6675273_-	ABC transporter permease	NA	NA	NA	NA
WP_002618658.1\|6675307_6677017_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_013376767.1\|6677511_6677919_+	hypothetical protein	NA	NA	NA	NA
WP_013376768.1\|6677957_6680135_-	SIR2 family protein	NA	NA	NA	NA
WP_002618660.1\|6680234_6681773_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_002618657.1\|6681807_6683016_-	MFS transporter	NA	NA	NA	NA
WP_157601388.1\|6683012_6683546_-	hypothetical protein	NA	NA	NA	NA
WP_002618661.1\|6683703_6684294_+	hypothetical protein	NA	NA	NA	NA
WP_002618656.1\|6684293_6685280_+	HTTM domain-containing protein	NA	NA	NA	NA
6687456:6687482	attL	NA	NA	NA	NA
WP_013376831.1\|6687785_6688181_+	hypothetical protein	NA	NA	NA	NA
WP_157601342.1\|6688228_6688519_+	IS66 family insertion sequence element accessory protein TnpB	S5VXZ8	Leptospira_phage	9.8e-07	35.4
WP_013375203.1\|6688563_6690225_+\|transposase	IS66 family transposase	A0A0P0ZBS5	Stx2-converting_phage	8.8e-60	36.4
WP_002618850.1\|6690516_6691092_+	hypothetical protein	NA	NA	NA	NA
WP_013376776.1\|6692583_6693090_-	DUF2381 family protein	NA	NA	NA	NA
WP_002614209.1\|6693088_6693898_+\|transposase	IS5-like element ISStau10 family transposase	NA	NA	NA	NA
WP_075298719.1\|6693897_6694326_+\|integrase	site-specific integrase	Q9T1P3	Pseudomonas_phage	1.6e-13	37.9
6694384:6694410	attR	NA	NA	NA	NA

DBSCAN-SWA_5

6932631 : 6940503

Staphylococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013376881.1\|6932631_6933822_-	3,4-dihydroxy-2-butanone-4-phosphate synthase	A0A2H4PQS2	Staphylococcus_phage	8.2e-68	41.5
WP_013376882.1\|6933833_6934484_-	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	3.1e-29	34.3
WP_002615971.1\|6934507_6935671_-	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2I2L4R9	Orpheovirus	2.4e-51	33.7
WP_013376883.1\|6935667_6936171_-	transcriptional repressor NrdR	NA	NA	NA	NA
WP_013376884.1\|6936181_6937438_-	serine hydroxymethyltransferase	A0A219Y950	Aeromonas_phage	2.1e-93	51.9
WP_013376885.1\|6937575_6938019_-	ribose 5-phosphate isomerase B	NA	NA	NA	NA
WP_037583790.1\|6938074_6939331_-	beta-ketoacyl-ACP synthase II	NA	NA	NA	NA
WP_002615974.1\|6939403_6939646_-	acyl carrier protein	M4QDG5	Prochlorococcus_phage	2.7e-10	57.5
WP_002615969.1\|6939753_6940503_-	3-oxoacyl-[acyl-carrier-protein] reductase	Q06VL0	Trichoplusia_ni_ascovirus	7.1e-25	35.1

DBSCAN-SWA_6

7520156 : 7580045

Leptospira_phage(18.18%)

protease,transposase,head,capsid,integrase

attL 7562823:7562848|attR 7580061:7580086

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_148273580.1\|7520156_7521794_+\|transposase	IS66 family transposase	A0A0P0ZEB3	Stx2-converting_phage	1.5e-35	28.3
WP_002617439.1\|7523476_7525378_+	collagen-like protein	NA	NA	NA	NA
WP_013377133.1\|7526137_7527391_-\|transposase	IS66 family transposase	A0A218MNE7	uncultured_virus	2.5e-59	38.5
WP_037584026.1\|7527896_7528352_+	GFA family protein	NA	NA	NA	NA
WP_002617457.1\|7528554_7529136_+	hypothetical protein	NA	NA	NA	NA
WP_157601379.1\|7529282_7529945_+	methyltransferase domain-containing protein	NA	NA	NA	NA
WP_002617447.1\|7530058_7530961_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_002617449.1\|7531943_7534403_-	helicase	A0A248SJQ0	Salicola_phage	5.7e-23	31.0
WP_002617442.1\|7534983_7536090_+	oxidoreductase	NA	NA	NA	NA
WP_013377139.1\|7536161_7536950_+	alpha/beta fold hydrolase	NA	NA	NA	NA
WP_002617448.1\|7537523_7539410_+	family 43 glycosylhydrolase	NA	NA	NA	NA
WP_002617450.1\|7539510_7540920_-	family 43 glycosylhydrolase	NA	NA	NA	NA
WP_002617451.1\|7541221_7543102_+	hypothetical protein	NA	NA	NA	NA
WP_041792127.1\|7543512_7543893_-	GFA family protein	NA	NA	NA	NA
WP_002614849.1\|7543969_7544998_-	hypothetical protein	NA	NA	NA	NA
WP_002614873.1\|7545223_7545979_+	DNA/RNA non-specific endonuclease	NA	NA	NA	NA
WP_081465953.1\|7546051_7546987_+	VanW family protein	NA	NA	NA	NA
WP_013377146.1\|7547010_7548063_+	LD-carboxypeptidase	NA	NA	NA	NA
WP_013377147.1\|7548101_7549079_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_157601337.1\|7549299_7550262_-	His-Xaa-Ser system radical SAM maturase HxsC	S5WIP3	Leptospira_phage	8.7e-76	46.7
WP_013377149.1\|7550460_7551903_-	His-Xaa-Ser system radical SAM maturase HxsB	S5VT21	Leptospira_phage	2.1e-94	37.0
WP_002614847.1\|7551913_7552273_-	His-Xaa-Ser system protein HxsD	NA	NA	NA	NA
WP_013377151.1\|7552262_7552868_-	hypothetical protein	NA	NA	NA	NA
WP_148273451.1\|7552864_7553413_-	hypothetical protein	NA	NA	NA	NA
WP_157601336.1\|7553827_7553986_+	hypothetical protein	NA	NA	NA	NA
WP_002614886.1\|7554038_7555004_-	NAD-dependent epimerase/dehydratase family protein	NA	NA	NA	NA
WP_013377153.1\|7555148_7556030_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_002614859.1\|7556166_7556925_+	SDR family oxidoreductase	A0A0M4JSW6	Mollivirus	1.6e-11	27.5
WP_013377155.1\|7557249_7558134_+	hypothetical protein	NA	NA	NA	NA
WP_013377156.1\|7558279_7558768_-	hypothetical protein	NA	NA	NA	NA
WP_002614872.1\|7558840_7559587_+	hypothetical protein	NA	NA	NA	NA
WP_002614875.1\|7559722_7560775_+	GntR family transcriptional regulator	NA	NA	NA	NA
WP_002614866.1\|7560846_7562460_+	kelch repeat-containing protein	NA	NA	NA	NA
7562823:7562848	attL	NA	NA	NA	NA
WP_002614880.1\|7563088_7564237_-	protein kinase	A0A2P1EMR8	Moumouvirus	3.2e-08	28.4
WP_002614858.1\|7564393_7566139_-	serine/threonine protein kinase	Q76UF0	Chlorella_virus	4.7e-11	25.2
WP_002614855.1\|7566135_7567008_-	DUF2381 family protein	NA	NA	NA	NA
WP_013377158.1\|7567615_7568701_-\|capsid	phage major capsid protein	NA	NA	NA	NA
WP_013377159.1\|7568697_7569528_-\|head,protease	HK97 family phage prohead protease	A0A142K631	Streptomyces_phage	1.3e-06	30.5
WP_002612100.1\|7569647_7571114_+\|transposase	IS66-like element ISStau2 family transposase	NA	NA	NA	NA
WP_002614877.1\|7571332_7571932_-	hypothetical protein	NA	NA	NA	NA
WP_013377162.1\|7572244_7573300_+	toll/interleukin-1 receptor domain-containing protein	NA	NA	NA	NA
WP_157601335.1\|7574089_7574227_+	hypothetical protein	NA	NA	NA	NA
WP_002614857.1\|7574229_7576557_+	DNA primase	A0A2D1GN57	Marinobacter_phage	3.4e-65	37.9
WP_002614868.1\|7576590_7576929_+	hypothetical protein	NA	NA	NA	NA
WP_013377164.1\|7577005_7578154_-	hypothetical protein	NA	NA	NA	NA
WP_013377165.1\|7578594_7578831_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_041792130.1\|7578827_7580045_+\|integrase	site-specific integrase	A0A2I7SC08	Paenibacillus_phage	7.0e-22	27.1
7580061:7580086	attR	NA	NA	NA	NA

DBSCAN-SWA_7

7590237 : 7599377

uncultured_Mediterranean_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002611037.1\|7590237_7591383_+	trypsin-like peptidase domain-containing protein	A0A1B1IT49	uncultured_Mediterranean_phage	2.9e-17	26.5
WP_002610985.1\|7591519_7591792_+	hypothetical protein	NA	NA	NA	NA
WP_013377168.1\|7591831_7592566_-	RNA methyltransferase	NA	NA	NA	NA
WP_002610899.1\|7592618_7593203_+	hypothetical protein	NA	NA	NA	NA
WP_013377169.1\|7593245_7594202_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A0M4JBD3	Mollivirus	3.1e-33	34.4
WP_013377170.1\|7594225_7595539_-	adenylosuccinate lyase	A0A2H4UUU6	Bodo_saltans_virus	2.1e-19	27.1
WP_013377171.1\|7595567_7597736_-	SUMF1/EgtB/PvdO family nonheme iron enzyme	A0A285PX80	Cedratvirus	7.3e-06	24.4
WP_002611063.1\|7597830_7598289_-	dUTP diphosphatase	A0A1Q1PNN8	Noumeavirus	9.9e-38	53.8
WP_013377172.1\|7598366_7599377_-	M23 family metallopeptidase	Q8SBN9	Clostridium_phage	4.9e-21	44.5

DBSCAN-SWA_8

7615959 : 7626330

Feline_leukemia_virus(14.29%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013377180.1\|7615959_7617570_+	serine/threonine protein kinase	A0A292G230	Feline_leukemia_virus	5.4e-14	28.8
WP_013377181.1\|7617576_7618113_-	stringent starvation family protein b	NA	NA	NA	NA
WP_002611020.1\|7618145_7618631_-	SsrA-binding protein SmpB	W5RAM5	Staphylococcus_phage	3.5e-33	50.0
WP_013377182.1\|7618645_7619500_-	pantoate--beta-alanine ligase	NA	NA	NA	NA
WP_013377183.1\|7619504_7620404_-	3-methyl-2-oxobutanoate hydroxymethyltransferase	A0A0P0BXC9	Ostreococcus_lucimarinus_virus	5.0e-49	40.2
WP_037583019.1\|7620566_7621214_-	deoxynucleoside kinase	A0A288TXV5	Enterococcus_phage	2.6e-15	32.0
WP_002611085.1\|7621360_7621642_+	hypothetical protein	NA	NA	NA	NA
WP_013377185.1\|7621649_7622486_-	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA	E4ZFQ0	Streptococcus_phage	7.4e-15	30.8
WP_013377186.1\|7622497_7623496_-\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD	A0A0R6PI74	Moraxella_phage	2.0e-75	46.2
WP_013377187.1\|7623540_7626330_-	response regulator	Q56AR1	Bacillus_thuringiensis_phage	5.0e-07	30.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_014623

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection