CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_014651	Geobacillus sp. Y4.1MC1 plasmid pGY4MC101, complete sequence	0 crisprs	NA	0	0	0	0
NC_014650	Geobacillus sp. Y4.1MC1, complete sequence	14 crisprs	DEDDh,csa3,cas3,DinG,cas6,csm6,cas7,cas5,cas4,cas1,cas2,cas7b,cas8b1	3	13	9	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_014650_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014650_1

92920-93028

Orphan

Consensus_repeat	Method
AGCAGTCTTGTGTCTGCGTCTGCAAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014650_1

>merge|NC_014650|1|92920-93028|CRISPRCasFinder
AGCAGTCTTGTGTCTGCGTCTGCAAGTGAATGCAAAGAAGTTGGATTCCTCGACGCAAGACAGCAAAGAAGTGAGCACAAGGTAGCAGTCTTGTGCCTGCGTCTGCAAG

>NC_014650|1|1|92920-93028|CRISPRCasFinder
AGCAGTCTTGTGTCTGCGTCTGCAAG	TGAATGCAAAGAAGTTGGATTCCTCGACGCAAGACAGCAAAGAAGTGAGCACAAGGT
AGCAGTCTTGTGCCTGCGTCTGCAAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_014650.1\|WP_013399819.1\|84968_85547_+\|aminodeoxychorismate/anthranilate-synthase-component-II	unknown	unknown	gnl\|CDD\|181066
NC_014650.1\|WP_003247516.1\|112930_113599_+\|serine-O-acetyltransferase	unknown	unknown	gnl\|CDD\|200082
NC_014650.1\|WP_003247490.1\|88110_88329_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NC_014650.1\|WP_003247512.1\|110537_111014_+\|2-C-methyl-D-erythritol-2,4-cyclodiphosphate-synthase	unknown	unknown	gnl\|CDD\|376811
NC_014650.1\|WP_003247508.1\|108715_109810_+\|PIN/TRAM-domain-containing-protein	unknown	unknown	gnl\|CDD\|227292
NC_014650.1\|WP_035502596.1\|104706_107142_+\|ATP-dependent-Clp-protease-ATP-binding-subunit	unknown	unknown	gnl\|CDD\|223616
NC_014650.1\|WP_003247497.1\|102588_103050_+\|CtsR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|226869
NC_014650.1\|WP_003247476.1\|82497_83424_+\|cysteine-synthase-A	unknown	unknown	gnl\|CDD\|273465
NC_014650.1\|WP_042385732.1\|83508_84957_+\|anthranilate-synthase-component-I	unknown	unknown	gnl\|CDD\|223225
NC_014650.1\|WP_003247481.1\|85551_86421_+\|aminodeoxychorismate-lyase	unknown	unknown	gnl\|CDD\|181067
NC_014650.1\|WP_003247493.1\|89436_90921_+\|lysine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234778
NC_014650.1\|WP_003247484.1\|86424_87279_+\|dihydropteroate-synthase	unknown	unknown	gnl\|CDD\|238380
NC_014650.1\|WP_003247502.1\|103617_104700_+\|protein-arginine-kinase	unknown	unknown	gnl\|CDD\|234894
NC_014650.1\|WP_013399820.1\|87631_88159_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	unknown	unknown	gnl\|CDD\|238269
NC_014650.1\|WP_013399823.1\|107230_108604_+\|DNA-repair-protein-RadA	unknown	unknown	gnl\|CDD\|236994
NC_014650.1\|WP_185948732.1\|109836_110520_+\|2-C-methyl-D-erythritol-4-phosphate-cytidylyltransferase	unknown	unknown	gnl\|CDD\|234670
NC_014650.1\|WP_003247500.1\|103064_103613_+\|UvrB/UvrC-motif-containing-protein	unknown	unknown	gnl\|CDD\|226397
NC_014650.1\|WP_003247514.1\|111121_112582_+\|glutamate--tRNA-ligase	unknown	unknown	gnl\|CDD\|234953
NC_014650.1\|WP_013399821.1\|88345_89347_+\|tRNA-dihydrouridine-synthase-DusB	unknown	unknown	gnl\|CDD\|129820
NC_014650.1\|WP_173662669.1\|87241_87631_+\|dihydroneopterin-aldolase	unknown	unknown	gnl\|CDD\|376737

Protein	Function_ID	Function_description	E-value
NC_014650.1\|WP_013399819.1\|84968_85547_+\|aminodeoxychorismate/anthranilate-synthase-component-II	gnl\|CDD\|181066	PRK07649, PRK07649, aminodeoxychorismate/anthranilate synthase component II.	2.91121e-141
NC_014650.1\|WP_003247516.1\|112930_113599_+\|serine-O-acetyltransferase	gnl\|CDD\|200082	TIGR01172, Serine_acetyltransferase, serine O-acetyltransferase. Cysteine biosynthesis [Amino acid biosynthesis, Serine family].	3.03376e-105
NC_014650.1\|WP_003247490.1\|88110_88329_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	1.40401e-13
NC_014650.1\|WP_003247512.1\|110537_111014_+\|2-C-methyl-D-erythritol-2,4-cyclodiphosphate-synthase	gnl\|CDD\|376811	pfam02542, YgbB, YgbB family. The ygbB protein is a putative enzyme of deoxy-xylulose pathway (terpenoid biosynthesis).	7.70698e-109
NC_014650.1\|WP_003247508.1\|108715_109810_+\|PIN/TRAM-domain-containing-protein	gnl\|CDD\|227292	COG4956, COG4956, Integral membrane protein (PIN domain superfamily) [General function prediction only].	0
NC_014650.1\|WP_035502596.1\|104706_107142_+\|ATP-dependent-Clp-protease-ATP-binding-subunit	gnl\|CDD\|223616	COG0542, clpA, ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones].	0
NC_014650.1\|WP_003247497.1\|102588_103050_+\|CtsR-family-transcriptional-regulator	gnl\|CDD\|226869	COG4463, CtsR, Transcriptional repressor of class III stress genes [Transcription].	1.75617e-76
NC_014650.1\|WP_003247476.1\|82497_83424_+\|cysteine-synthase-A	gnl\|CDD\|273465	TIGR01139, Cysteine_synthase, cysteine synthase A. This model distinguishes cysteine synthase A (CysK) from cysteine synthase B (CysM). CysM differs in having a broader specificity that also allows the use of thiosulfate to produce cysteine thiosulfonate. [Amino acid biosynthesis, Serine family].	5.5717e-180
NC_014650.1\|WP_042385732.1\|83508_84957_+\|anthranilate-synthase-component-I	gnl\|CDD\|223225	COG0147, TrpE, Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism].	0
NC_014650.1\|WP_003247481.1\|85551_86421_+\|aminodeoxychorismate-lyase	gnl\|CDD\|181067	PRK07650, PRK07650, 4-amino-4-deoxychorismate lyase; Provisional.	0
NC_014650.1\|WP_003247493.1\|89436_90921_+\|lysine--tRNA-ligase	gnl\|CDD\|234778	PRK00484, lysS, lysyl-tRNA synthetase; Reviewed.	0
NC_014650.1\|WP_003247484.1\|86424_87279_+\|dihydropteroate-synthase	gnl\|CDD\|238380	cd00739, DHPS, DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and protein biosynthesis. Prokaryotes (and some lower eukaryotes) must synthesize folate de novo, while higher eukaryotes are able to utilize dietary folate and therefore lack DHPS. Sulfonamide drugs, which are substrate analogs of pABA, target DHPS.	9.33553e-133
NC_014650.1\|WP_003247502.1\|103617_104700_+\|protein-arginine-kinase	gnl\|CDD\|234894	PRK01059, PRK01059, ATP:guanido phosphotransferase; Provisional.	0
NC_014650.1\|WP_013399820.1\|87631_88159_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	gnl\|CDD\|238269	cd00483, HPPK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a carrier-mediated active transport system. Most microbes and plants lack this system and must synthesize folates de novo from guanosine triphosphate. One enzyme from this pathway is HPPK which catalyzes pyrophosphoryl transfer from ATP to 6-hydroxymethyl-7,8-dihydropterin (HP). The functional enzyme is a monomer. Mammals lack many of the enzymes in the folate pathway including, HPPK.	1.93157e-70
NC_014650.1\|WP_013399823.1\|107230_108604_+\|DNA-repair-protein-RadA	gnl\|CDD\|236994	PRK11823, PRK11823, DNA repair protein RadA; Provisional.	0
NC_014650.1\|WP_185948732.1\|109836_110520_+\|2-C-methyl-D-erythritol-4-phosphate-cytidylyltransferase	gnl\|CDD\|234670	PRK00155, ispD, D-ribitol-5-phosphate cytidylyltransferase.	6.59195e-113
NC_014650.1\|WP_003247500.1\|103064_103613_+\|UvrB/UvrC-motif-containing-protein	gnl\|CDD\|226397	COG3880, COG3880, Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms].	1.63309e-62
NC_014650.1\|WP_003247514.1\|111121_112582_+\|glutamate--tRNA-ligase	gnl\|CDD\|234953	PRK01406, gltX, glutamyl-tRNA synthetase; Reviewed.	0
NC_014650.1\|WP_013399821.1\|88345_89347_+\|tRNA-dihydrouridine-synthase-DusB	gnl\|CDD\|129820	TIGR00737, Probable_tRNA-dihydrouridine_synthase, putative TIM-barrel protein, nifR3 family. This model represents one branch of COG0042 (Predicted TIM-barrel enzymes, possibly dehydrogenases, nifR3 family). This branch includes NifR3 itself, from Rhodobacter capsulatus. It excludes a broadly distributed but more sparsely populated subfamily that contains sll0926 from Synechocystis PCC6803, HI0634 from Haemophilus influenzae, and BB0225 from Borrelia burgdorferi. It also excludes a shorter and more distant archaeal subfamily.The function of nifR3, a member of this family, is unknown, but it is found in an operon with nitrogen-sensing two component regulators in Rhodobacter capsulatus.Members of this family show a distant relationship to alpha/beta (TIM) barrel enzymes such as dihydroorotate dehydrogenase and glycolate oxidase. [Unknown function, General].	1.00682e-164
NC_014650.1\|WP_173662669.1\|87241_87631_+\|dihydroneopterin-aldolase	gnl\|CDD\|376737	pfam02152, FolB, Dihydroneopterin aldolase. This enzyme EC:4.1.2.25 catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin in the biosynthetic pathway of tetrahydrofolate.	2.74722e-51

>NC_014650.1|WP_003247493.1|89436_90921_+|lysine--tRNA-ligase
MSHEELNDQLRVRREKLHKLREMGIDPFGKRFERTHKAQELFDLYGDLSKEELEEKQIKVAVAGRIMTKRGKGKAGFAHIQDVTGQIQIYVREDAVGPEQYELFKTSDLGDIIGVCGTVFKTKVGELSIKVSSYEFLTKALRPLPEKYHGLKDIEQRYRQRYLDLIMNPDSKNTFITRSRIIQSMRRYLDSHGYLEVETPMMHNIAGGAAARPFITHHNALDMPLYMRIAIELHLKRLIVGGLEKVYEIGRVFRNEGVSTRHNPEFTMLELYEAYADFRDIMTLTENLIAHIAQEVLGTTKIQYGEHKVDLTPEWKRLHMVDAIKEYVGVDFWKQMSDEEARELAKEHGVEIAPHMTFGHIVNEFFEQKVEDKLIQPTFIYGHPVEISPLAKKNPDDPRFTDRFELFIVGREHANAFTELNDPIDQRERFEAQLKEREQGNDEAHEMDEDFIEALEYGMPPTGGLGIGVDRLVMLLTNSPSIRDVLLFPQMRNK
>NC_014650.1|WP_013399821.1|88345_89347_+|tRNA-dihydrouridine-synthase-DusB
MFKIGDVEIKNRVVLAPMAGVCNSAFRLTVKEFGAGLVCAEMVSDKGIVYNNEKTLNMLYIDEREKPLSLQIFGGEKETLVEAAKFVDKHTNADIIDINMGCPVPKVTKCDAGAKWLLDPNKIYDVVAAIVDAVEKPVTVKMRIGWDENHIYAVENAQAVERAGGKAVAVHGRTRVQMYEGKADWNIIKQVKEAVNIPVIGNGDVKTPQDAKRMLEETGVDGVMIGRAALGNPWMIYRTVRYLETGELIPEPTVREKIEVCLLHLDRLIALKGEHIAVKEMRKHAAWYLKGVRGNAKIRNAINECETREQLAALLLNFAEEVESKEQMNAQAV
>NC_014650.1|WP_003247490.1|88110_88329_+|helix-turn-helix-transcriptional-regulator
MEAEKWGRRIRAFRKLKGYTQERLAKELGISVSILGEIERGNRLPTEELVQQIAERLNISVEELAPHSEAGK
>NC_014650.1|WP_013399820.1|87631_88159_+|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase
MENHAYIALGSNIGDRFFYLREAVKMLDSHQQISVAAASSIYETEPVGYIHQNKFLNMVVKIYTSLSPFALLDVTQKIEQNFGRKREMRWGPRTLDLDILLYNHENIETEQLIIPHPRMTERAFVMIPLLELNRDIHIPNVTQCLLHLVDRLPDKEGVRVWKQKNGEDVFALFES
>NC_014650.1|WP_173662669.1|87241_87631_+|dihydroneopterin-aldolase
MQCLEKEWRTIDKIYLHRMEFYGYHGVLPEENVLGQRFIVDAILETDLQKAGKSDQLNDTINYAEVYDICRNVVEKRRFSLIEAVAETIAEQILSSFPTVARCTIKVTKPNPPIKGHYESVAVEIVRGR
>NC_014650.1|WP_003247484.1|86424_87279_+|dihydropteroate-synthase
MATTSATPFVLRCGDYELDLRKKTMVMGIVNVTPDSFSDGGRFYDLDRAVEHAKQLVADGADIIDIGGESTRPGAEKVSLEEELRRVIPVVKAVAQEINVPISIDTYKAEVAKQAIEAGAHIINDVWGAKADEKMAEVAAFYDVPIILMHNRHDLQYRDLISDMISDLMESVAIVKRAGVKDENIILDPGIGFAKTLEHNLEIMRRLDEFAKLGYPLLLGTSRKRFIGHVLDLPVDERVEGTGATVCLGIAKGAHIVRVHDVLPIARMVKMMDAMLGKGVANDR
>NC_014650.1|WP_003247481.1|85551_86421_+|aminodeoxychorismate-lyase
MYIYVNGEVVHKDEARISPFDHGFLYGLGVFETFRTYDGHPFLLDDHLERLNRSLREMNIAKSFTRREVMEILHRLLEANRLQNAYVRLNVSAGIGDIGLQTSEYDQPTVIMYMKPLFSSFSRGKIGIVLKTRRNTPEGKERLKSHHYLNNIIGKREIGTRPDVEGIFLNEQGYVAEGIVSNIFWVKNGVVYTPAIHAGILNGVTRQFVIALLNALKIECQEGFYPLDHLQRADEIFVTNSIQEIVPIYQMDGRAYQGADGPVTSLLQKHYKHFTSFLWTKYELAERME
>NC_014650.1|WP_013399819.1|84968_85547_+|aminodeoxychorismate/anthranilate-synthase-component-II
MILMIDNYDSFTYNLVQYLGVLGEELVVKRNDEITVKEIETLNPDFLMISPGPCTPNEAGVSIEAIEYFAGKIPVFGVCLGHQAIAQAFGGKVVRADRLMHGKTSQIFHDGKTIFTNIPSPFTATRYHSLIVEKETLPDCFEISAWTEENEIMAIRHKTLPVEGVQFHPESIMTSHGMKLLENFIQTYKRVR
>NC_014650.1|WP_042385732.1|83508_84957_+|anthranilate-synthase-component-I
MQWLNKGSDIAVRKWGNRKRRTLPYSNRDWFRQYKALAAHEPYHVLLESGQGGRYSIIGLTPAGVIQAKENQLFISYHGETKWYEGNPLLSLKQWFAQFPLHFSKSELPFQGGAIGYISYDCARYIEKIPSYAQDDLQLPSMYFLIFDDVFVYDHQKQLLHMIVHYADGEELEAERRLSFYESRWLEAEQCEGEWMFQKQDANPSVSMTKADFVEAVQKVQQYIAQGDVFQVNLSVRQSKPLLTHPFHIYEQLRVINPSPYMAYIHFPEFQIVSGSPELLVKKRGDDISTRPIAGTRSRGKTEEEDKWLATKLLSSEKEIAEHAMLVDLERNDLGRVCQYGTVKVDEWMTIERYSHVMHIVSHVSGKLKQGKDAFDVIQAMFPGGTITGAPKVRTMEIIEELEPVRRGIYTGSIGWISFDGDMEFNIAIRTMIAKDGIAHVQAGAGIVIDSHPEHEYRECLKKAAALWKAKELSEAEKSLRV
>NC_014650.1|WP_003247476.1|82497_83424_+|cysteine-synthase-A
MARTVNSVTELIGDTPAVKLNRIVDEDSADVYLKLEFMNPGSSVKDRIALAMIEAAEKEGKIKPGDTIVEPTSGNTGIGLAMVAAAKGYKAILVMPDTMSLERRNLLRAYGAELVLTPGSQGMRGAIAKAEELVKEHGYFMPQQFKNEANPEIHRLTTGKEIVEQMGDQLDAFIAGVGTGGTITGAGQVLREKYPNIKIYAVEPADSPVLSGGKPGPHKIQGIGAGFVPDILDTSIYDGVITVTTEEAFAAARRAAREEGILGGISSGAAIHAALKIAKQLGKGKKVLAIIPSNGERYLSTPLYQFDE
>NC_014650.1|WP_003247497.1|102588_103050_+|CtsR-family-transcriptional-regulator
MPNISDIIEQYLKQVLNMSDKDIVEIKRSEIADKFQCVPSQINYVINTRFTLERGYVVESKRGGGGYIRIMKVKTKSEAQLIDQLLELVGHHVSQSNAEDIIHRLVEEKVISEREAKIMLSVMDRSVLCIDLPQRDELRARMLRAMLTSLKYK
>NC_014650.1|WP_003247500.1|103064_103613_+|UvrB/UvrC-motif-containing-protein
MICQECKQRPATMHFTKIINGEKTEFHLCEQCAHEHSDMFTFYGNDDFSFNNLLSALLNFPSSMKELTTSSFHNPDILQCEKCNMTYQQFTKIGHFGCSHCYRTFSRYLPPILKRLHSGNTAHAGKIPKRKGGTLHLRKQIAMLKQKLQEFVAREEFEKAAEVRDQIRSLEYQLHQRGEGEM
>NC_014650.1|WP_003247502.1|103617_104700_+|protein-arginine-kinase
MSFEKFFNTAVSSWMSQEGPDSDIVLSSRIRLARNIVDFRFPTLFSNEEAQQIVSLFEQTFAHRFYRSVGRFELLKMSELQPIEKRVLVEKHLISPHLAEDSPFGACLLSENEEISIMINEEDHIRIQCLFPGFQLTEALKAANELDDWIEEHVIYAFDEKLGYLTSCPTNVGTGMRASVMMHLPALVLTQQMNRIIPAVNQLGLVVRGTYGEGSEALGNIFQISNQMTLGKSEEDIVEDLKSVVQQLITQERMARETLVKTLNIQLEDRVFRSYGILANSRVIDSKEAAQCLSDVRLGIDLGYIKNISRNILNELMILTQPGFLQQYAGGVLRPEERDVRRAALIRERLKMEERKMNGG
>NC_014650.1|WP_035502596.1|104706_107142_+|ATP-dependent-Clp-protease-ATP-binding-subunit
MMFGRFTERAQKVLALAQEEAIRLGHNNIGTEHILLGLIREGEGIAAKALMALGLGPEKIQKEVESLIGRGHEVSHTIHYTPRAKKVLELSMDEARKLGHSYVGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNESVSGHSGGGASHVSTPTLDSLARDLTAIAREGRLDPVVGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIAEGLAQQIINNEVPETLRDKRVMTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIILFIDELHTLIGAGGAEGAIDASNILKPALARGELQCIGATTLDEYRKYIEKDAALERRFQPIYVDEPTVEESIQILKGLRDRYEAHHRVSISDDAIVQAVKLSDRYITDRFLPDKAIDLIDEACSKVRLRSFTAPPKLKELEQKLEEVRKEKDAAVQSQEFEKAASLRDMEQRLREELEETKRAWKEKQGQENSEVTVEDIAMVVSSWTGIPVAKLAQTETERLLKLEEILHSRVVGQDEAVKAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAEAMFGDEDALIRIDMSEYMEKHSTSRLIGSPPGYVGYEEGGQLTEKVRRKPYSVVLLDEMEKAHPDVFNILLQVLEDGRLTDSKGRTVDFRNTIIIMTSNVGADALKRNKYVGFNVQDEDQKYKDMKGKVMDELKRAFRPEFLNRIDEIIVFHSLEKQHLKQIVKLMADTLIKRLKEQDIDLELTDAAIEKIVSEGYDPEYGARPLRRALQKQVEDRLSEELLKGTIAKGQKVIVDVKDGEFVVLAKQAVM
>NC_014650.1|WP_013399823.1|107230_108604_+|DNA-repair-protein-RadA
MGKKKTKFVCQECGYESAKWLGRCPGCNTWNSMVEEIERTKPATKGVFVHSASDIISKPVPITTVTATQEPRIQTGISEFNRVLGGGIVKGSLVLIGGDPGIGKSTLLLQVSAQLAALQHKVLYISGEESVKQTKLRADRLHVASDQLYVLAETDLEYIVEAIETIHPVCVVIDSIQTIYRADIASAPGSVSQVRECTAELMKIAKTKGITIFIVGHVTKEGAIAGPRILEHMVDTVLYFEGERHHTYRILRAVKNRFGSTNEIGIFEMRESGLVEVENPSEVFLEERSRGAAGSTVVAAMEGTRPVLVEIQALVSPTSFGNPRRMATGIDHNRVSLLMAVLEKRSGLLLQNQDAYLKVAGGVKLDEPAIDLAIAVSIASSFRDQPTNPHDVIIGEVGLTGEVRRVSRIEQRVQEAVKLGFSRMIIPKNNLAGWNPPEHITVIGVSHITEALEHTLQ
>NC_014650.1|WP_003247508.1|108715_109810_+|PIN/TRAM-domain-containing-protein
MVKRIVQLFFLVVGGTLGVVFLPNLLQLMNISDISLLNNSYTLAVLGALIFFMMTFWLVDYVVDMIRWVEETLVKAPAADLLFGSLGLIFGLIVAFLVVMPLQAFQFQVVNTVLPIFLTILLGYLGFQVGFKKRHELMNLFSLSNRMAKKKGTEGETDLPKGGSLKILDTSVIIDGRIADICKTGFLEGTLVIPRFVLEELQHIADSSDVLKRNRGRRGLDILNRIQKELDIKVEIYEGDFDDIQEVDSKLVKLAKLTSGVVVTNDFNLNKVCELQNVRVLNINDLANAVKPVVLPGEELNVHVIKDGKEHNQGVAYLDDGTMIVVEDGKEYIGKRVDVLVTSVLQTSAGRMIFAKLKLLQKAL
>NC_014650.1|WP_185948732.1|109836_110520_+|2-C-methyl-D-erythritol-4-phosphate-cytidylyltransferase
MYEVVIPAAGQGKRMKAGMNKQLIELRNEPLIVRTLKVFENDEWCRGIIVVINEAERTQFEQLFSRFHIKKITAVVGGGKERQHSVYNGLRAVKNSDIVLIHDGARPFVTIEQIHELVNEAKEHGAAIPAVRVKDTIKKVCDQFVEETVERSGLWAVQTPQAFHVSLVLRAHEQAQKDGYIGTDDASLVERIGGKVKIIEGDYRNIKLTTPDDLLFAEVILSSWVSS
>NC_014650.1|WP_003247512.1|110537_111014_+|2-C-methyl-D-erythritol-2,4-cyclodiphosphate-synthase
MFRIGQGFDVHQLVEGRPLIIGGVRIPYEKGLLGHSDADVLLHAVADACLGAIGAGDIGKHFPDTDERYKDADSALLLKQVWELVKRQGYKLVNLDCTVIAQKPKMAPHIEQMKENIAKLLEGESSQVNIKATTTEKLGFTGRGEGIAAQAVVLLQKQ
>NC_014650.1|WP_003247514.1|111121_112582_+|glutamate--tRNA-ligase
MSQEVRVRYAPSPTGHLHIGGARTALFNYLFARHHNGKFIVRIEDTDIERNVEGGEQSQLENLKWLGIDYDESVDKDGGYGPYRQTERLDIYRKYVNELLEKGYAYKCFCTPEELEQEREAQRAAGIAAPQYSGKCRHLTKEQIAQLEAEGKPYTIRVKVPEGKVYEFEDIVRGKVTFESKDIGDWVIMKANGIPTYNFAVVIDDHLMKITHVFRGEEHLSNTPKQLMIYDYFGWEPPQFGHLTLIVNENRKKLSKRDESIIQFVSQYKELGYLPEALFNFFALLGWSPEGEEEIFSKEELIRIFDVSRLSKSPSMFDTKKLTWMNNQYIKKLDLDRLVEISLPHLIKAGRLPEQMSEEQRQWARDLIALYQEQMSYGAEIVQLSELFFKEDIEYNEEAKEVLSGEQVPDVLKAFLEEVKQLDPFTAENIKAAIKSVQKSTGQKGKKLFMPIRVAATGQTHGPELPVALQLLGKEKVISRLEKVVH
>NC_014650.1|WP_003247516.1|112930_113599_+|serine-O-acetyltransferase
MFKTLKEDIEVIFEQDPAARSYLEVILTYSGLHAIWAHRIAHALYKRKFYFLARLISQISRFFTGIEIHPGAKIGRRFFIDHGMGVVIGETCEIGDNVTVYQGVTLGGTGKEKGKRHPTIKDNCLIAAGAKVLGSITIGENSKIGAGSVVLKDVPPNSTVVGIPGRVVVRDGVKVKKDLNHTDLPDPVADRIKELEAEIAKLRSEIESLKERKNEHEQHSAL

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Crispr_ID: NC_014650_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014650_2

228716-228803

Orphan

Consensus_repeat	Method
GCTGGCTGGTTGTTTGAATACAAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014650_2

>merge|NC_014650|2|228716-228803|CRISPRCasFinder
GCTGGCTGGTTGTTTGAATACAAACGAAATTCGGACGCTTTCTTCCCTTTTGCTTCCAGAATCAGCTGGCTGATTGTTTGAATACAAA

>NC_014650|2|2|228716-228803|CRISPRCasFinder
GCTGGCTGGTTGTTTGAATACAAA	CGAAATTCGGACGCTTTCTTCCCTTTTGCTTCCAGAATCA
GCTGGCTGATTGTTTGAATACAAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_014650.1\|WP_013399867.1\|236099_237176_-\|dipeptide-epimerase	unknown	unknown	gnl\|CDD\|239435
NC_014650.1\|WP_003247710.1\|233277_233478_+\|DUF3311-domain-containing-protein	unknown	unknown	gnl\|CDD\|371707
NC_014650.1\|WP_003247700.1\|225036_226872_+\|APC-family-permease	unknown	unknown	gnl\|CDD\|223605
NC_014650.1\|WP_013399862.1\|218227_218938_+\|DsbA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|239322
NC_014650.1\|WP_013399861.1\|217393_218086_+\|DUF1129-family-protein	unknown	unknown	gnl\|CDD\|181074
NC_014650.1\|WP_148259566.1\|229123_229360_+\|hypothetical-protein	unknown	unknown	unknown
NC_014650.1\|WP_013399865.1\|232043_233228_+\|amidohydrolase	unknown	unknown	gnl\|CDD\|349941
NC_014650.1\|WP_013399866.1\|235070_236078_-\|C40-family-peptidase	unknown	unknown	gnl\|CDD\|366353
NC_014650.1\|WP_013399863.1\|219501_220827_+\|S8-family-peptidase	unknown	unknown	gnl\|CDD\|173812
NC_014650.1\|WP_013399864.1\|230789_232019_+\|Zn-dependent-hydrolase	unknown	unknown	gnl\|CDD\|236456
NC_014650.1\|WP_173662690.1\|220840_222781_-\|sulfatase-like-hydrolase/transferase	unknown	unknown	gnl\|CDD\|224287
NC_014650.1\|WP_003247719.1\|239108_240092_+\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_014650.1\|WP_003247704.1\|227750_228710_+\|sporulation-protein	unknown	unknown	gnl\|CDD\|369195
NC_014650.1\|WP_003247699.1\|223265_224606_+\|TrkH-family-potassium-uptake-protein	unknown	unknown	gnl\|CDD\|273349
NC_014650.1\|WP_003247690.1\|215286_216513_+\|threonine-synthase	unknown	unknown	gnl\|CDD\|181283
NC_014650.1\|WP_013876128.1\|229335_230637_+\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|225222
NC_014650.1\|WP_003247718.1\|238437_238785_-\|DUF3870-domain-containing-protein	unknown	unknown	gnl\|CDD\|372419
NC_014650.1\|WP_003247717.1\|237194_238358_-\|DUF819-domain-containing-protein	unknown	unknown	gnl\|CDD\|227792
NC_014650.1\|WP_003247691.1\|217064_217397_+\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NC_014650.1\|WP_003247702.1\|226981_227641_+\|sporulation-membrane-protein-YtaF	unknown	unknown	gnl\|CDD\|274321

Protein	Function_ID	Function_description	E-value
NC_014650.1\|WP_013399867.1\|236099_237176_-\|dipeptide-epimerase	gnl\|CDD\|239435	cd03319, L-Ala-DL-Glu_epimerase, L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of the murein peptide of peptidoglycan, of which L-Ala-D-Glu is a component. L-Ala-D/L-Glu epimerase is a member of the enolase-superfamily, which is characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion.	4.55869e-132
NC_014650.1\|WP_003247710.1\|233277_233478_+\|DUF3311-domain-containing-protein	gnl\|CDD\|371707	pfam11755, DUF3311, Protein of unknown function (DUF3311). This is a family of short bacterial proteins of unknown function.	1.21887e-13
NC_014650.1\|WP_003247700.1\|225036_226872_+\|APC-family-permease	gnl\|CDD\|223605	COG0531, PotE, Amino acid transporters [Amino acid transport and metabolism].	1.23617e-24
NC_014650.1\|WP_013399862.1\|218227_218938_+\|DsbA-family-oxidoreductase	gnl\|CDD\|239322	cd03024, DsbA_FrnE, DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins.	5.49505e-103
NC_014650.1\|WP_013399861.1\|217393_218086_+\|DUF1129-family-protein	gnl\|CDD\|181074	PRK07668, PRK07668, hypothetical protein; Validated.	1.04122e-08
NC_014650.1\|WP_013399865.1\|232043_233228_+\|amidohydrolase	gnl\|CDD\|349941	cd08021, M20_Acy1_YhaA-like, M20 Peptidase aminoacylase 1 subfamily, includes Bacillus subtilis YhaA and Staphylococcus aureus amidohydrolase, SACOL0085. Peptidase M20 family, uncharacterized subfamily of bacterial proteins predicted as putative amidohydrolases or hippurate hydrolases. These are a class of zinc binding homodimeric enzymes involved in hydrolysis of N-acetylated proteins. N-terminal acetylation of proteins is a widespread and highly conserved process that is involved in protection and stability of proteins. Several types of aminoacylases can be distinguished on the basis of substrate specificity. Aminoacylase 1 (ACY1) breaks down cytosolic aliphatic N-acyl-alpha-amino acids (except L-aspartate), especially N-acetyl-methionine and acetyl-glutamate into L-amino acids and an acyl group. However, ACY1 can also catalyze the reverse reaction, the synthesis of acetylated amino acids. ACY1 may also play a role in xenobiotic bioactivation as well as the inter-organ processing of amino acid-conjugated xenobiotic derivatives (S-substituted-N-acetyl-L-cysteine). This family includes Staphylococcus aureus amidohydrolase, SACOL0085, which contains two manganese ions in the active site, and forms a homotetramer with variations in interdomain orientation which possibly plays a role in the regulation of catalytic activity.	0
NC_014650.1\|WP_013399866.1\|235070_236078_-\|C40-family-peptidase	gnl\|CDD\|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	6.86978e-34
NC_014650.1\|WP_013399863.1\|219501_220827_+\|S8-family-peptidase	gnl\|CDD\|173812	cd07487, Peptidases_S8_1, Peptidase S8 family domain, uncharacterized subfamily 1. This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	2.29721e-126
NC_014650.1\|WP_013399864.1\|230789_232019_+\|Zn-dependent-hydrolase	gnl\|CDD\|236456	PRK09290, PRK09290, allantoate amidohydrolase; Reviewed.	0
NC_014650.1\|WP_173662690.1\|220840_222781_-\|sulfatase-like-hydrolase/transferase	gnl\|CDD\|224287	COG1368, MdoB, Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane].	0
NC_014650.1\|WP_003247719.1\|239108_240092_+\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.74985e-129
NC_014650.1\|WP_003247704.1\|227750_228710_+\|sporulation-protein	gnl\|CDD\|369195	pfam07070, Spo0M, SpoOM protein. This family consists of several bacterial SpoOM proteins which are thought to control sporulation in Bacillus subtilis.Spo0M exerts certain negative effects on sporulation and its gene expression is controlled by sigmaH.	3.49085e-67
NC_014650.1\|WP_003247699.1\|223265_224606_+\|TrkH-family-potassium-uptake-protein	gnl\|CDD\|273349	TIGR00933, Trk_system_potassium_uptake_protein_trkH., potassium uptake protein, TrkH family. The proteins of the Trk family are derived from Gram-negative and Gram-positive bacteria, yeast and wheat. The proteins of E. coli K12 TrkH and TrkG as well as several yeast proteins have been functionally characterized.The E. coli TrkH and TrkG proteins are complexed to two peripheral membrane proteins, TrkA, an NAD-binding protein, and TrkE, an ATP-binding protein. This complex forms the potassium uptake system. [Transport and binding proteins, Cations and iron carrying compounds].	3.42578e-110
NC_014650.1\|WP_003247690.1\|215286_216513_+\|threonine-synthase	gnl\|CDD\|181283	PRK08197, PRK08197, threonine synthase; Validated.	0
NC_014650.1\|WP_013876128.1\|229335_230637_+\|transcriptional-regulator	gnl\|CDD\|225222	COG2345, COG2345, Predicted transcriptional regulator [Transcription].	0.00114778
NC_014650.1\|WP_003247718.1\|238437_238785_-\|DUF3870-domain-containing-protein	gnl\|CDD\|372419	pfam12986, DUF3870, Domain of unknown function (DUF3870). A family based on the C-terminal domain of 3KOG which shows structural similarity to pore-forming proteins, suggesting it may have a lytic function.	2.03319e-42
NC_014650.1\|WP_003247717.1\|237194_238358_-\|DUF819-domain-containing-protein	gnl\|CDD\|227792	COG5505, COG5505, Predicted integral membrane protein [Function unknown].	1.09768e-109
NC_014650.1\|WP_003247691.1\|217064_217397_+\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	3.81002e-25
NC_014650.1\|WP_003247702.1\|226981_227641_+\|sporulation-membrane-protein-YtaF	gnl\|CDD\|274321	TIGR02840, conserved_hypothetical_protein, putative sporulation protein YtaF. This protein family was identified, at the time of the publication of the Carboxydothermus hydrogenoformans genome, as having a phylogenetic profile that exactly matches the subset of the Firmicutes capable of forming endospores. The species include Bacillus anthracis, Clostridium tetani, Thermoanaerobacter tengcongensis, Geobacillus kaustophilus, etc. This protein, previously named YtaF, is therefore a putative sporulation protein. [Cellular processes, Sporulation and germination].	5.33075e-55

>NC_014650.1|WP_003247704.1|227750_228710_+|sporulation-protein
MWKKLLSKLGVGAAKVDLVLHHPRVRVGEQLKGEFLIEGGTVEQHIRKLEVELQLMVQADGKAYRRTVAVIPVSSSFTIQPGERKALPFSYVLPLHLPITRPRVRYAFVTRLDIADGVDAFDQDAIDILPPLPLEKLFHALGNIGFREKPSSGKITAYGQEFAFFPTKEWMGVVEEVEFSAQIEENGIRLYLEVDVRSGFGGFHETELKREIFFSNEEIENVEEMSGKLRAVIGEMIQQPRSYVGPSHVPYSSYPSQHVSHHHGGHGMMGAIGGFAAGMLAGMVAEELLEDVVEDALDDGIEDVMDDIGDWFDGGDDIL
>NC_014650.1|WP_003247702.1|226981_227641_+|sporulation-membrane-protein-YtaF
MWKYISMIMLAFVVSMDSLSVGVTYGIRKIQFPLRSKLVIACMSGAMLLLSMCVGSVFLLFLPGQAERWLASAILIALGIWAIYNVVKKETDKEEKMEPLAPPPRIKAWRFQLKRFGIVVQVLKCPAMGDLDSSGSISMKEAMLIGFALSMDAFGAGISASFLKYPPLLLALLVCTLNIIFIGLGLKAGNLLSKIKAVRKVTVIPGTILICLGIMKIFF
>NC_014650.1|WP_003247700.1|225036_226872_+|APC-family-permease
MASLKRLLIGSPMETKRLQHEKLPKWKALAVFSSDALSSVAYATEEILLVLMLLGTSVFFYSLPIAVAILVLLLLVTLSYRQIIYAFPSGGGAYVVARDHLNTTTSLVAGAALMIDYVLTVAVSISSGVAALTSAFPGLLPWKVEIAVALVLLLMILNLRGITESATVFAYPTYLFIISVLVLIVAGGWQLWHEGWHGFNYKEHASAAHFFASGYSMFILLRAFASGCSAMTGIEAISNGVPAFKPDSSKNAAITMGWMSLLLGTMFLGITVLAAGFGVTPVEHKTVISQIGHHVFGNSIFFYLFQMITMFILVLAANTSFAGFPQLASIIANDRFLPRSLSARGDRLVFSNGIILLSILAIVLIVAFHGETHSLIPLYAVGVFLSFTIGQSGLLKKIWKEKEKRNITTLVIVMTGMTVTGLVTVITVVAKFTQGAWLVIVAIPSLVWLFYRIHDHYVKLGEQLKLDEQEWTRREKMLKPKVIIPISGVSKVVAQSVQYARSISNDITAVSVIFYEEEEQKLRAKWEKFYPDIPLRVIYSPYRTILSPILDYINEVEKQANSSPITILMPQFVVKKWWHALLHNQTAVVLRFFLIMKKDIVIATLPYHLKE
>NC_014650.1|WP_003247699.1|223265_224606_+|TrkH-family-potassium-uptake-protein
MKKARKYYLDPPKVLVAGFAVIILVGTALLMLPIATNDGKGLPFLDALFTATSATCVTGLVVVDTGTAFTLFGQLVILALIQVGGLGFMTFATLFAFLLGKRISLKERLLLQEAMNNLTIEGIVRLVKRVLIFTVVIELIGGLLLAVRFSFDMPLLKAFYFGMFHAVSNFNNAGFDLMGNFRSLTGYVEDPVVTLVICALITLGGIGFIVMNEVYEYRQTRRFSLHTKVAVATSGILLASSILLIFLLEFHNPNTLEPLSPLGKFLATLYQAVTPRTAGSNTLNISDLTQPTLFLIIFLMFVGASPGSTGGGIKTTTFAILLGAVWSQIRGKEDVVFFKKRIMYDTIYKSLTVTISGLFIVIFVTMLLTITEQGKDFLMILFEATSAFSTVGLSMGLTPELSPFGKVIIMCTMFAGRVGPLTIAYAVTLHRKPDPFRYPKGKIMIG
>NC_014650.1|WP_173662690.1|220840_222781_-|sulfatase-like-hydrolase/transferase
MLEKYRSLPDQYISFFIFAIFLFWMKTYAAYQAEFHLGISNSMQEFLLFINPVSSAVFFFGLALLAKGKRTYTWLIIINFVLSFILYANIVYYRFFSDFITLPTLTQTKNFGDLGSSIWELIKWYDIFYFLDTVILIAIVTSKRFSLPAVQVGRYKKSIVFAIAALIFSVNLALAEMDRPQLLTRTFDRNYIVKYLGVYNYLIYDAVQSMKSSTQRAFANKSDITTVLNHVQATYAKPNPQYFGVAKGMNVIYIHLESFQNFLINYKLHGQEVTPFLNSLVRDPNTFYFDNFFHQTGQGKTSDAEFMLENSLFGLPQGAVFTTKGQNTYHAAPALLHQHGYTTAVFHGNYKTFWNRDEIYKSFGFDHFFDASYYDMSDENVLNYGLKDKPFFRESIPLLESLREPFYVKFITLSNHFPYPISEEDATIEPANTGDGSVDRYFQTARYLDESLKEFFDYLKKSGLYDRSVIILYGDHYGISENHNKAMSQVLGKEITPFEHAQLQRVPLFIRVPGVKGGIMHQYGGQIDLLPTVLHLLGIDTKNYVHFGTDLLSPEHQEIVPFRNGDFVTPTVTAVNGKYYDSKTGEPIPETPEVKQLEQIVRTKLDLSDKVVYGDLLRFYTPKGFKPVDPTKYDYNNRDEEKKGSK
>NC_014650.1|WP_013399863.1|219501_220827_+|S8-family-peptidase
MFEYSIVQLARHYAHKLDRPLRHFLVSIYKPFLYTPCIIHKQLERWMKKMKRIPVIIQFHEENGVFALKEVEKQHFRMKIHHQFRYIPSCSAEVTPQALEQILQRHDVKKVYLNRKVSALLNNAVPSANAKNVAVNGTALSGKGVTIAIVDTGIYPHPDLEGRIAGFVDFVNGRTEPYDDNGHGTHCAGDAAGNGSVSSGLYRGPAYEANVVGVKVLNKVGAGRLDTIIRGIEWCIQYNETSKDEKIDIISLSLGGESQPFPEENDDPLVQAAEKAWDKGIVVCAAAGNAGPEYRTISSPGISDKIITVGALDDRDTAETREDDEIANFSSRGPTYYGVSKPDIVVPGVNIVSLRAPKSFLDKYQKQNRIGQYYMSMSGTSMATPICAGIVALMLQYKPDATPDEIKRALKEGAGLWKDRDPNIYGAGYVDAQRAIGLLAK
>NC_014650.1|WP_013399862.1|218227_218938_+|DsbA-family-oxidoreductase
MKIEVWSDFVCPFCYIGKRRLEKALEQFPHKDQVEVVFRSFELDPDAKKHYDMSIHEIIAKKYGISVEEAKRVNADIGRQAESVGLTFRFDTMKPTNTFDAHRLAKYAEERGKLPEVAERLFQAYFTDSQQISDHNVLIDLAGEAGLDREEARQVLESSRYGDEVRKDEAEAARLGVRGVPFFVLNRKYAISGAQPIEVFMQALEKVWEEEKTTSPLQPLASDGGGQCTDGSCQVQ
>NC_014650.1|WP_013399861.1|217393_218086_+|DUF1129-family-protein
MNAKDLVALNNEKRKQLNEHNRNYYENMLVYIRSQLLLSEQQSEELLMELLDHLLEAQKHGKMAEDIFGTDAKAYCDELIRQLPKEKKRNIYAFIGYLAVRLFALGVLVTGAVELVAEWFTDVDDTVYLGKASVLFVIDFAVILLAVALVMRWIRKSAFHDDSSTFGGKVKEFLGIWFACCLVIGMFVLAEKLVPEFGYRIEAGGMVRILFGLFVFAVTWRLNKKFRITK
>NC_014650.1|WP_003247691.1|217064_217397_+|PadR-family-transcriptional-regulator
MSLRSQLLKGVLEGCILAIIKKESVYGYELSVKLQKFGLNDVSEGSIYPLLLRLQKAGLIKGEMRDSPSGPKRKYYHLTEKGEEALQDFIAEWESIRKPVEKILRGGNME
>NC_014650.1|WP_003247690.1|215286_216513_+|threonine-synthase
MPFSYVSHLYCPKCQKTYGTNKKHQLCECGSPLLVAYHLDALRADLSREIIASREPNLWRYHELLPVENPEHIVSLGEGMTPLVPMPRLGKDMDIEQLYMKDEGVIPTGTFKARGAAVGISKAKELGVKKLAMPTNGNAGAAWSLYAARAGIQVTVVMPVDAPTITRNECAIAGADLYLVNGLISDAGAIVSKAIQERNLYDASTLKEPYRIEGKKTMGLEIAEQFSWQLPDVILYPTGGGVGLIGIYKALKELQDLGWVQGKMPRLVAVQAQNCAPIVKAWNERKRVSEFWPNSSTVAFGINVPKALGDFLVLDALYKTDGCAIAVEDDAIINEQRNVANLEGAFICPEGAAAFVAARRLRERGWIRRGERVVVLNTGIGLKYTHTVSIEVPILQPGDHLPERKDYS
>NC_014650.1|WP_148259566.1|229123_229360_+|hypothetical-protein
MRIGKERNQQELDHHINRSGARVFEAVANKTYDRQEIRAIAEKMIAGLLVDMPVAVLATRNFSALKRRDRRFAYGWEY
>NC_014650.1|WP_013876128.1|229335_230637_+|transcriptional-regulator
MRIRLGILGADDSLAIIQNVTNEYKELHCIPVIYWDEEEIIDFIRPYMHQVDMWLFSGQVPYSIVKEWGEIDCPMFYVPHTGASLYRTLLRIYYERQIPVQQLSFDTYHPSEIERLLEEVGIGERVPYVKHYQGGISAAALAQYHYGLWKQGLTKAAVTCLRTAQLELEKLGVPVYRVLPARSAVESVVQMIIRTGEMLRFQDAQIAVQMMEVDSLFAISNETFSTDEIYKMEMKVTEKLLKYAKKIQGSLKIAGPGRYVIFTTRGALKDITDHYKIIPTIKELEDMDREIAACGIGVGRTAYEAEIHAGKAFLHAKKYGRGTWMVVFDDDTIAGPLGRAEQIRYSFDCAELQAISQKTNLSVATLSKISAILRKLGKNEMNAYELAAYMQILPRSARRILHELEMKGLAEVVGETNPYPRGRPRKVYRIFLG
>NC_014650.1|WP_013399864.1|230789_232019_+|Zn-dependent-hydrolase
MINGDRLWNRLLELGTIGKQPSGGITRLSFTKEERAAKEKVVSYMKEAGLAVYEDAVGNLIGRKEGKEKDAPAVLVGSHIDSVYNGGMFDGPLGVLAAVEVLQTMNERGVKTKHPIEVVAFTDEEGARFSYGMIGSRGMAGTLSEEELVHQDKHGISLAAAMEEAGLDPGKIGKAARRKGSVKAYVELHIEQGRVLEQANLPVGIVTGIAGLIWAKLTITGKAEHAGATPMPIRRDPLVAAAQIIQVIEQEAKKTGTTVGTVGQMQVFPGGINIIPERVEFSLDLRDLDAAVRDSVFLSIIERAKQIGNERNVDVAVELLQKMPPVLCSELVQNAAKEACRQLGFDVFTLPSGASHDGVQLAGLCPIGMIFVRSKDGVSHSPEEWSSKEDCAAGANVLYHTVLSLAMTA
>NC_014650.1|WP_013399865.1|232043_233228_+|amidohydrolase
MTNEEIKRLVDEVKEEVIAWRRHLHANPELSFQEEKTAQFVYETLQSFGNLEISRPTKTSVMARLIGPQPGRVVAIRADMDALPIQEENTFAFASKNPGVMHACGHDGHTAMLLGTAKILSQLRDQIKGEIRFLFQHAEELHPGGAEEMVQAGVMDGVDVVIGTHLWSPLERGKIGIVYGPMMAAPDRFFIRIHGKGGHAALPHQTIDAIAVGAQVVTNLQYIVSRNVDPLEPLVVSVTQFVAGTTHNVIPGSVEIQGTVRSFDETLRKSVPKLMERIIKGITEAHGATYEFEFEYGYRPVINNNEVTRVIEETVREVFGEEAVDHIKPNMGGEDFSAFQQKAPGSFFYVGAGNKEKGIVYPHHHPRFTIDEDALEIGVRLFVHAAFKLLAEVS
>NC_014650.1|WP_003247710.1|233277_233478_+|DUF3311-domain-containing-protein
MKGIRWLMVLPFLGILGGIPFANKVTPYVLGMPFILFWLVAWVIMTSIIMAVVYRFDPDVREEERT
>NC_014650.1|WP_013399866.1|235070_236078_-|C40-family-peptidase
MKKWKWYLTAFLCFCMVFGFLSPANAKTDNDEAAYVDVSVATLWTEPNIARDIDSPSLSNPVDMWKWTKSMTYEEKLWLVGNLETQALYGMKVTILEKRGDWAKVVVHGQPTPRHPLGYPGWMPIRQLTKGKVFAPFQAKPFAQVTSPTAWLYKDPKGNHKFMEISFNTRLPVVHSTKNAVKVRTPSDGAKWLKKEDVQIFRTEADIPSPTGEDLVNTAKQFLGLPYLWAGTSGFGFDCSGFTHTIYKAHGITIPRDSSVQAQFGIPVPESELQPGDLLFFAYNNGKGRIHHVGMYIGNGKMIHSPNSSTTVRIDDYRAPGYGEEFAGARRYIQK
>NC_014650.1|WP_013399867.1|236099_237176_-|dipeptide-epimerase
MKIKDATIAVQSTPLIKPFKTALRTATQIESIVVKITLDNGMEGYGAAVPTEAITGETKQGIIGVLENVLIPKIIGREIEEINKNDKDIQTSCIGNTSAKAALEMAMYDALCKLLNIPLYQLFGGKMNHHVNDMTISVNNVEEMVNDAKKVTEKGFSILKIKVGKEAEKDIERIERIYDEVGPNISLRIDANQGWTAKDAVKIIQSLEQLHLPIEFIEQPVSKHDIKGLQFIRERVNVPIMADESVFSARDALELIRHHAVDLINIKLMKTGGLREAYKIASLAEAAGIECMIGSMMEPTLSVLAAAHLAMAHPNITKVDLDAPLWINDDSSRSFFQESKINVPDLPGIGYVPSMPNH
>NC_014650.1|WP_003247717.1|237194_238358_-|DUF819-domain-containing-protein
MIQDGVVYLSILLAYVALIAFAEQKSKSKLFKVVPGIIFIYVGGALMQTFGVFGKTNSIDNTYNTVRNVLLPAMLILMLLHCDLRKIIKMGPKILLTFFAASFTIIIGFTVTYLLLKEFYAKDTWKAFAALSSSWTGGSANMVILQKILDVPENIFGYALIMDTVNYSIWVMFMFWLVPFADRFNRWTKAKAIEVPVAADEVATTTENHQGKMGFTELIVLLGFSILLSTICTEIGNALPELGAVFNGTTWTIVFASVIGLLLAMTKAAKIPGANDVSKVMLYVIIALIASKADFSQLFQAPIYIISGFLILLIHALLMLIIAKVCKLDLFTMGVTSLANIGGVASTPILAGAYHQSLIPVGILTALLGNLLGTYYGLLTARILSSL
>NC_014650.1|WP_003247718.1|238437_238785_-|DUF3870-domain-containing-protein
MFENNTVYIIGDAKAPSNNPITQQYKAFFIGLVVNKENSMIVDADCSATIELTKSFVKSLLVGRSILDIDTVTKEIQTRYFGSSQKAFIVAFKNASLKYQNIVSSAASSVLSSRR
>NC_014650.1|WP_003247719.1|239108_240092_+|LacI-family-DNA-binding-transcriptional-regulator
MATIRDVAKLAGVSVATVSRVLNQNGYVNEETEKRVRQAMKELNYKPSEVARALFKKTSKTIGLIVPDITNPFFPELVRAVEDVMNIYDYTVILCNSDEKTEKEKKYIEVLKQKYVDGIILTTNQLELEEVSEWNVPMVVLDRPLSHNYPSVIADNYGGARLATKHLYDIGCRKIAHIQGPSHVVNAMERFHGYRDEMMELGLWDERLVILGNYQLKKAKEAVIEALNKYDIDGIFAGNDAMAVGALKAVQQMGFRVPEDIAIIGYDGIPLTEMTTPELSTISQPIYDMGAIAARILIKQIEGKPLEKLHYVLPVELVVRQSTRRGE

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Crispr_ID: NC_014650_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014650_3

263676-264506

Orphan

Consensus_repeat	Method
GTTTGTATCTTACCTATGAGGAATTGAAAC	PILER-CR
GTTTGTATCTTACCTATGAGGAATTGAAAC	CRISPRCasFinder
GTTTGTATCTTACCTATGAGGAATTGAAAC	CRT

12 spacers

The CRISPR arrays of NC_014650_3

>merge|NC_014650|3|263676-264506|PILER-CR,CRISPRCasFinder,CRT
GTTTGTATCTTACCTATGAGGAATTGAAACGTGAGGTTGTATAGAAAGGAGATAGCAAGAAATGAAGTTTGTATCTTACCTATGAGGAATTGAAACTAGGGCTTGCGTCTGAATCTCTTGTGAAAAAACTCAAGTTTGTATCTTACCTATGAGGAATTGAAACGGATTAGTTGGCGCTGTTTTAGGACCATTGTTAGCAAGTTTGTATCTTACCTATGAGGAATTGAAACTTCTCCTCTTGTTGGTCAATATATTGTTTGTAATTGTTTGTATCTTACCTATGAGGAATTGAAACCCAAAAGACTCGGGATGATGATATTTTTGGGATTCTGTTTGTATCTTACCTATGAGGAATTGAAACACTTTTATCGAGCCGAGTGAAACAGATACGAATAAAGTTTGTATCTTACCTATGAGGAATTGAAACGGTATAAGTTCGATCTTTCGCTTTCCAGCTTGGATTTTGGTTTGTATCTTACCTATGAGGAATTGAAACTGACGCTATTTGGAATTTGTTAAGAGAAGAAGGATTAGTTTGTATCTTACCTATGAGGAATTGAAACTCAAATGAGGTGATTACATATGGAAGAAAAATATGTAGGTTTGTATCTTACCTATGAGGAATTGAAACAACGTCACCATGTGATAATGGATTGCGCCGCGTTTCTGTTTGTATCTTACCTATGAGGAATTGAAATGGTCATAACTAGAACGTCTTTCCTTGCGCGCAAAACCGTTTGTATCTTACCTATGAGGAATTGAAACGCGTCTTTTGCAGCAGTGACTCTCACATTGGTTGCGGTTTGTATCTTACCTATGAGAAGTTGAAAC

>NC_014650|3|1|263676-264506|PILER-CR
GTTTGTATCTTACCTATGAGGAATTGAAAC	GTGAGGTTGTATAGAAAGGAGATAGCAAGAAATGAA
GTTTGTATCTTACCTATGAGGAATTGAAAC	TAGGGCTTGCGTCTGAATCTCTTGTGAAAAAACTCAA
GTTTGTATCTTACCTATGAGGAATTGAAAC	GGATTAGTTGGCGCTGTTTTAGGACCATTGTTAGCAA
GTTTGTATCTTACCTATGAGGAATTGAAAC	TTCTCCTCTTGTTGGTCAATATATTGTTTGTAATT
GTTTGTATCTTACCTATGAGGAATTGAAAC	CCAAAAGACTCGGGATGATGATATTTTTGGGATTCT
GTTTGTATCTTACCTATGAGGAATTGAAAC	ACTTTTATCGAGCCGAGTGAAACAGATACGAATAAA
GTTTGTATCTTACCTATGAGGAATTGAAAC	GGTATAAGTTCGATCTTTCGCTTTCCAGCTTGGATTTTG
GTTTGTATCTTACCTATGAGGAATTGAAAC	TGACGCTATTTGGAATTTGTTAAGAGAAGAAGGATTA
GTTTGTATCTTACCTATGAGGAATTGAAAC	TCAAATGAGGTGATTACATATGGAAGAAAAATATGTAG
GTTTGTATCTTACCTATGAGGAATTGAAAC	AACGTCACCATGTGATAATGGATTGCGCCGCGTTTCT
GTTTGTATCTTACCTATGAGGAATTGAAAT	GGTCATAACTAGAACGTCTTTCCTTGCGCGCAAAACC
GTTTGTATCTTACCTATGAGGAATTGAAAC	GCGTCTTTTGCAGCAGTGACTCTCACATTGGTTGCG
GTTTGTATCTTACCTATGAGAAGTTGAAAC

>NC_014650|3|3|263676-264506|CRISPRCasFinder
GTTTGTATCTTACCTATGAGGAATTGAAAC	GTGAGGTTGTATAGAAAGGAGATAGCAAGAAATGAA
GTTTGTATCTTACCTATGAGGAATTGAAAC	TAGGGCTTGCGTCTGAATCTCTTGTGAAAAAACTCAA
GTTTGTATCTTACCTATGAGGAATTGAAAC	GGATTAGTTGGCGCTGTTTTAGGACCATTGTTAGCAA
GTTTGTATCTTACCTATGAGGAATTGAAAC	TTCTCCTCTTGTTGGTCAATATATTGTTTGTAATT
GTTTGTATCTTACCTATGAGGAATTGAAAC	CCAAAAGACTCGGGATGATGATATTTTTGGGATTCT
GTTTGTATCTTACCTATGAGGAATTGAAAC	ACTTTTATCGAGCCGAGTGAAACAGATACGAATAAA
GTTTGTATCTTACCTATGAGGAATTGAAAC	GGTATAAGTTCGATCTTTCGCTTTCCAGCTTGGATTTTG
GTTTGTATCTTACCTATGAGGAATTGAAAC	TGACGCTATTTGGAATTTGTTAAGAGAAGAAGGATTA
GTTTGTATCTTACCTATGAGGAATTGAAAC	TCAAATGAGGTGATTACATATGGAAGAAAAATATGTAG
GTTTGTATCTTACCTATGAGGAATTGAAAC	AACGTCACCATGTGATAATGGATTGCGCCGCGTTTCT
GTTTGTATCTTACCTATGAGGAATTGAAAT	GGTCATAACTAGAACGTCTTTCCTTGCGCGCAAAACC
GTTTGTATCTTACCTATGAGGAATTGAAAC	GCGTCTTTTGCAGCAGTGACTCTCACATTGGTTGCG
GTTTGTATCTTACCTATGAGAAGTTGAAAC

>NC_014650|3|1|263676-264506|CRT
GTTTGTATCTTACCTATGAGGAATTGAAAC	GTGAGGTTGTATAGAAAGGAGATAGCAAGAAATGAA
GTTTGTATCTTACCTATGAGGAATTGAAAC	TAGGGCTTGCGTCTGAATCTCTTGTGAAAAAACTCAA
GTTTGTATCTTACCTATGAGGAATTGAAAC	GGATTAGTTGGCGCTGTTTTAGGACCATTGTTAGCAA
GTTTGTATCTTACCTATGAGGAATTGAAAC	TTCTCCTCTTGTTGGTCAATATATTGTTTGTAATT
GTTTGTATCTTACCTATGAGGAATTGAAAC	CCAAAAGACTCGGGATGATGATATTTTTGGGATTCT
GTTTGTATCTTACCTATGAGGAATTGAAAC	ACTTTTATCGAGCCGAGTGAAACAGATACGAATAAA
GTTTGTATCTTACCTATGAGGAATTGAAAC	GGTATAAGTTCGATCTTTCGCTTTCCAGCTTGGATTTTG
GTTTGTATCTTACCTATGAGGAATTGAAAC	TGACGCTATTTGGAATTTGTTAAGAGAAGAAGGATTA
GTTTGTATCTTACCTATGAGGAATTGAAAC	TCAAATGAGGTGATTACATATGGAAGAAAAATATGTAG
GTTTGTATCTTACCTATGAGGAATTGAAAC	AACGTCACCATGTGATAATGGATTGCGCCGCGTTTCT
GTTTGTATCTTACCTATGAGGAATTGAAAT	GGTCATAACTAGAACGTCTTTCCTTGCGCGCAAAACC
GTTTGTATCTTACCTATGAGGAATTGAAAC	GCGTCTTTTGCAGCAGTGACTCTCACATTGGTTGCG
GTTTGTATCTTACCTATGAGAAGTTGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_014650.1\|WP_013399890.1\|272543_273512_-\|aliphatic-sulfonate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270275
NC_014650.1\|WP_003247766.1\|270379_271708_-\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274819
NC_014650.1\|WP_013399882.1\|257115_258573_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|225519
NC_014650.1\|WP_013399892.1\|274806_275586_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224041
NC_014650.1\|WP_013399888.1\|267865_268879_-\|methionine-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|236863
NC_014650.1\|WP_013399886.1\|264899_266288_-\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274819
NC_014650.1\|WP_013399881.1\|256106_257123_+\|sugar-binding-protein	unknown	unknown	gnl\|CDD\|380537
NC_014650.1\|WP_003247754.1\|262592_263414_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_014650.1\|WP_013399883.1\|258569_260120_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|227095
NC_014650.1\|WP_185948734.1\|260228_261557_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|224567
NC_014650.1\|WP_003247768.1\|271738_272515_-\|aliphatic-sulfonate-ABC-transporter-permease-SsuC	unknown	unknown	gnl\|CDD\|183100
NC_014650.1\|WP_013399880.1\|255130_255865_-\|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224651
NC_014650.1\|WP_013399879.1\|253669_255106_+\|glycoside-hydrolase-family-1-protein	unknown	unknown	gnl\|CDD\|225343
NC_014650.1\|WP_013399887.1\|266335_267166_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|270317
NC_014650.1\|WP_013399889.1\|268956_270282_-\|acyl-CoA/acyl-ACP-dehydrogenase	unknown	unknown	gnl\|CDD\|224871
NC_014650.1\|WP_003247739.1\|251118_252096_+\|alpha-ketoacid-dehydrogenase-subunit-beta	unknown	unknown	gnl\|CDD\|223101
NC_014650.1\|WP_003247752.1\|261621_262593_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NC_014650.1\|WP_003247760.1\|267210_267876_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224922
NC_014650.1\|WP_013399891.1\|273577_274696_-\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274652
NC_014650.1\|WP_013399878.1\|252113_253478_+\|FAD-binding-protein	unknown	unknown	gnl\|CDD\|178402

Protein	Function_ID	Function_description	E-value
NC_014650.1\|WP_013399890.1\|272543_273512_-\|aliphatic-sulfonate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270275	cd13557, PBP2_SsuA, Substrate binding domain of sulfonate binding protein, a member of the type 2 periplasmic binding fold superfamily. This subfamily includes the sulfonate binding domains SsuA found in eubacterial SsuA proteins that serve as initial receptors in the ABC transport of bicarbonate, nitrate, taurine, or a wide range of aliphatic sulfonates, while other closest homologs are involved in thiamine (vitamin B1) biosynthetic pathway and desulfurization (DszB). After binding the ligand, SsuA interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The SsuA proteins belong to the PBPII superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	6.279e-122
NC_014650.1\|WP_003247766.1\|270379_271708_-\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|274819	TIGR03860, FMN_nitrolo, FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family. This model represents a distinctive clade, in which all characterized members are FMN-binding, within the larger family of luciferase-like monooxygenases (LLM), among which there are both FMN- and F420-binding enzymes. A well-characterized member is nitrilotriacetate monooxygenase from Aminobacter aminovorans (Chelatobacter heintzii), where nitrilotriacetate is a chelating agent used in detergents. [Unknown function, Enzymes of unknown specificity].	0
NC_014650.1\|WP_013399882.1\|257115_258573_+\|sensor-histidine-kinase	gnl\|CDD\|225519	COG2972, COG2972, Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms].	1.13541e-54
NC_014650.1\|WP_013399892.1\|274806_275586_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224041	COG1116, TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism].	3.55309e-112
NC_014650.1\|WP_013399888.1\|267865_268879_-\|methionine-ABC-transporter-ATP-binding-protein	gnl\|CDD\|236863	PRK11153, metN, DL-methionine transporter ATP-binding subunit; Provisional.	0
NC_014650.1\|WP_013399886.1\|264899_266288_-\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|274819	TIGR03860, FMN_nitrolo, FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family. This model represents a distinctive clade, in which all characterized members are FMN-binding, within the larger family of luciferase-like monooxygenases (LLM), among which there are both FMN- and F420-binding enzymes. A well-characterized member is nitrilotriacetate monooxygenase from Aminobacter aminovorans (Chelatobacter heintzii), where nitrilotriacetate is a chelating agent used in detergents. [Unknown function, Enzymes of unknown specificity].	0
NC_014650.1\|WP_013399881.1\|256106_257123_+\|sugar-binding-protein	gnl\|CDD\|380537	cd06314, PBP1_tmGBP, periplasmic sugar-binding domain of Thermotoga maritima glucose-binding protein (tmGBP) and its close homologs. Periplasmic sugar-binding domain of Thermotoga maritima glucose-binding protein (tmGBP) and its close homologs from other bacteria. They are members of the type 1 periplasmic binding protein superfamily which consists of two domains connected by a three-stranded hinge. TmGBP is specific for glucose and its binding pocket is buried at the interface of the two domains. TmGBP also exhibits high thermostability and the highest structural similarity to E. coli glucose binding protein (ecGBP).	1.78804e-112
NC_014650.1\|WP_003247754.1\|262592_263414_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	2.84386e-79
NC_014650.1\|WP_013399883.1\|258569_260120_+\|response-regulator-transcription-factor	gnl\|CDD\|227095	COG4753, COG4753, Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms].	5.89712e-83
NC_014650.1\|WP_185948734.1\|260228_261557_+\|extracellular-solute-binding-protein	gnl\|CDD\|224567	COG1653, UgpB, ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism].	3.0957e-56
NC_014650.1\|WP_003247768.1\|271738_272515_-\|aliphatic-sulfonate-ABC-transporter-permease-SsuC	gnl\|CDD\|183100	PRK11365, ssuC, aliphatic sulfonate ABC transporter permease SsuC.	7.06173e-105
NC_014650.1\|WP_013399880.1\|255130_255865_-\|MurR/RpiR-family-transcriptional-regulator	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	1.14066e-62
NC_014650.1\|WP_013399879.1\|253669_255106_+\|glycoside-hydrolase-family-1-protein	gnl\|CDD\|225343	COG2723, BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase [Carbohydrate transport and metabolism].	0
NC_014650.1\|WP_013399887.1\|266335_267166_-\|hypothetical-protein	gnl\|CDD\|270317	cd13599, PBP2_lipoprotein_Gna1946, The membrane-associated lipoprotein Gna1946 from Neisseria meningitidis; the type 2 periplasmic binding protein fold. Gna1946 shares significant structural and sequence homology with the periplasmic substrate-binding domain of ATP-binding cassette (ABC) transporter involved in uptake of methionine (MetQ). The members of the MetQ-like family include the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum, the membrane-associated lipoprotein-9 GmpC from Staphylococcus aureus, and Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus. They all function as a receptor for methionine. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.	1.32339e-107
NC_014650.1\|WP_013399889.1\|268956_270282_-\|acyl-CoA/acyl-ACP-dehydrogenase	gnl\|CDD\|224871	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism].	2.64579e-58
NC_014650.1\|WP_003247739.1\|251118_252096_+\|alpha-ketoacid-dehydrogenase-subunit-beta	gnl\|CDD\|223101	COG0022, AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion].	0
NC_014650.1\|WP_003247752.1\|261621_262593_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	2.35284e-79
NC_014650.1\|WP_003247760.1\|267210_267876_-\|ABC-transporter-permease	gnl\|CDD\|224922	COG2011, AbcD, ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism].	1.13708e-94
NC_014650.1\|WP_013399891.1\|273577_274696_-\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|274652	TIGR03565, alk_sulf_monoox, alkanesulfonate monooxygenase, FMNH(2)-dependent. Members of this protein family are monooxygenases that catalyze desulfonation of aliphatic sulfonates such as methane sulfonate. This enzyme uses reduced FMN, although various others members of the same luciferase-like monooxygenase family (pfam00296) are F420-dependent enzymes. [Central intermediary metabolism, Sulfur metabolism].	9.15093e-121
NC_014650.1\|WP_013399878.1\|252113_253478_+\|FAD-binding-protein	gnl\|CDD\|178402	PLN02805, PLN02805, D-lactate dehydrogenase [cytochrome].	1.09948e-128

>NC_014650.1|WP_003247754.1|262592_263414_+|carbohydrate-ABC-transporter-permease
MWQRAWSRLFLYAICIFMSLFFLMPVYVMLVTSVKPLDEVTLADMWKLPSAFDWSSYQTAFAKLAPNFWNSVYLVVPATLLSAILGALNGYVLSKWKFKGADTIFTLILFGMFIPYQSILIPLIQFLREIGLYNTIPGLIFVHVVYGIPITTLMFRNFYAAIPDEMIESAKIDGAGFLRIFRYIMLPLSVTGFVVVAIWQFTNIWNEFLFAVTITTSSQQPIMVALQNLSGSQIVQWNVQMAGALLAALPTLLVYIFLGKYFVRGLLAGSVKG
>NC_014650.1|WP_003247752.1|261621_262593_+|sugar-ABC-transporter-permease
METVKTVSERSVTAVPAPRKKRKWTADHWLAIAFLTPSVVLIFIFVYGFIGWTGYVSLSNWNSLVPDLSFAGLKNYVYLFHDFRFQADLRNTLVFTILFIGVVIVLGQLLAVLLDQKLRGESLFRNIFFFPMALSFVVTGVVWQWLLNPSTGVNLFLKKIGLDSKWYTDTTIFGGFHLGKIEFGVPVAIVAVVIAAVWQMTGFAVAMYLAGLRAIPEEVREAARIDGATELQIYRKIIIPLLRPITVSVIIIMAHISLKIFDLIYAMTGPGANFVTDVPGVYMFETTFRGNYYANGAAIAVIMLLSVAIFIVPYLISGRKGGA
>NC_014650.1|WP_185948734.1|260228_261557_+|extracellular-solute-binding-protein
MKVLSNIKGEESVKKKRLWLSLALVAGLALSGCNSDSASNSKEDQGGSKGHEKLEIFSWWTGAGEEDGLKALLKLFQEKYPDIPVENAAVAGGAGTNAKAVLASRMQGNDPPATFQVHGGAELNEGWVAAGKMEPLNDLYEKEGWMDKFPKSLIDMVSKDGKIYSVPVNIHRGNVLWYNKKIFAENGLEPPKTFDEFFQVADKLKAKGITPLALGDKEPWTATHIFETVLLGTLGTEDYKKLWTGELPFDDPKVKEAVNTFKKMLDYVNEDHSSRNWQDAAQLVGKGEAAMNIMGDWVKGYFVNDLKLKVNEDFGYVPTPNTEGKFMVITDTFGLPKGVKNPDDVKKFLSVLGSVEGQDAFNPLKGSIPARIDADTSKYDEYGKQTMEDFKTAELAPSLAHGSAAPEGFVTKVNQAVNIFVTQKDAKTFIDTLVSASAELKK
>NC_014650.1|WP_013399883.1|258569_260120_+|response-regulator-transcription-factor
MKIAIVDDEALERKALQKMIRGHLPTMEVIAEAANGREAVEVADQYKPDVMLMDIKMPGIDGLEAIELIRRKHPEIKFIIVSAFDTFDYAKQAMRHGVKEYLLKPSRKEEVVGALQRVYDELMEERRKEEENRELQQRVRQLQKLVEKEWLSVLMLEEVSSQEWKQWETLLPFSIDTGMFMVIQFPSGEKREDWKNWIEQVLSEKETTHYIIGKMVDGQMPVLFFHDVAVKAFSWKPVIQSLSLELIQQFERQYGTALYIGLGSPASRLEELRHSYYEALAAAQYYASQKKAKSGFLPKKSVLAAASGHIEKEKRLLDAVRQGDLEQALLQCYTYIEEEAAHHPLSVVQQKLEETFVLLGRMFADFGIAYERTATFHSCRSFEELKKTAAEQLRHMTCHILAWRHQQANGKLGKAKDYIDEHYHHPLTLEEVAEYVDISPCYFSKLFKDRFGMTFIDYVTDVRIARAKKEMADPNKSLKEICFLVGYNDPNYFSRVFKKHTGMSPSEYRKKLHAAT
>NC_014650.1|WP_013399882.1|257115_258573_+|sensor-histidine-kinase
MIKIRTKALFYFGIFIVLLNGTVFFFYQSSEDIVTDYDYSMRRLLLFNEISQRTNRMVEQLNAYLTEKDGRYFREYERQYRWLQQHRRQVGETLSNRNNRLLVKNYEHMIESLLEEGALTVYHFQAGNISLYSSHLHEAMKIASFIQETTLSLIDEELTTYQHFYNEVEARNRYFRYMGIGLSMTTFLLGVLLAVWFSGGLTRPIARLSRAAREIASGKLDGPDVISTTNDELKLLTDTFNDMRRNLKRLIEEMKQKSELDRLVKELELKSLQSQMNPHFLFNTLNAVAKMAYLEEANQTSRLIEAIAAILRYNLGDLQRTVTLADEVRIAHEYFFIQQTRFFDRIKFSMDVEESCLSLPIPPLTLQPLIENAFIHGIESYEKGAVLSLTVEKRKNLVVIEIRDNGVGMSEEVKEKLTAFIKGEEAGSISHGQTRGHSTGIGMYNVIRRLQLFYGMQDVIEIESAAGKGTTIRLLLPITKGGRGE
>NC_014650.1|WP_013399881.1|256106_257123_+|sugar-binding-protein
MSRTWWKWVIYAGSIAALIVSASFTIYCAWKVYAYHQPGEGAAAEAEKNAFHFVLVPEELDNDYWRLVEQGAKAAAKETGVYLEYAGPRQANIDEHIHILEKAAASKVDGIMTQGLTEKEFTPVINHIVEKNIPVVTIDTDAPTSKRTAYIGTDNYYAGFIAGRALEEDMHGKANVAIITGSFTASNQQLRVQGFKDAVKEEKGIHIVAVEESHITRVQAAEKAYNILKKHPEVNAFYGTSALDAIGIAKVVEQFHREKGTYIIGFDTLPETIRYLQKGTIHATVVQEPYEMGYRAVKMMVDIRKGNNVPSVINTETKVIRKQDLPLRPSRNYEVNHD
>NC_014650.1|WP_013399880.1|255130_255865_-|MurR/RpiR-family-transcriptional-regulator
MFTPEQIARFSELDYIIYNYVTKHANEVVYMRIRELAEEVHVSPPTILRFCRKVGCDGFSEFKTKLKLYLQQNERSFITNAQDTLTEFFERTLKIDYQQTIREAAAAIARADNVIFVGSGSSGILAEYGSRYFSALKKFSVYIKDPFFPIYGHYFNNCVVIALSVSGETSYTLSQVHRFKEKGSTIISITNRKHCSLANMSDYNLTYYVNTEFVEQTNITTQIPVIYLLESLAKEMYRMLNKPT
>NC_014650.1|WP_013399879.1|253669_255106_+|glycoside-hydrolase-family-1-protein
MEHKQLRPFPDRFLWGSASAAYQVEGAWNEDGKGLSVWDVFAKQPGRTFKGTNGDVAVDHYHRYKEDVALMAEMGLKAYRFSVAWSRVFPNEKGEINEKGLQFYDNLINELLKHNIEPIITLYHWDVPQALMDEYGAWESRQIIDDFHDYAVTLFQRFGDRVKYWVTLNEQNLFITFGYRLGLHPPGVKDAKRMYEANHIANLANAKVIQAFRHYVPDGKIGPSFAYSPMYPYDCRPENVLAWENAEEFQNHWWMDVYVWGTYPQAAWNYLEQQGWAPTIKSGDMELLKAGKPDFMGVNYYRSQTVQYNPLDGVGEGVMNTTGKKGTSTESGIPGLFKIVRNPHLEATNWDWEIDPVGLRIGLRRIANRYGLPVFITENGLGEFDKLEDGDIVNDDYRIDYLRRHIQEIQRAITDGVDVIGYCTWSFTDLLSWLNGYQKRYGFVYVNRDDESEKDLRRIKKKSFYWYKQVIASNGKEL
>NC_014650.1|WP_013399878.1|252113_253478_+|FAD-binding-protein
MGVYEDLLEQIGDRERVTVNETVLEQHSKGIAYHAPRKPDVVVFPKTAAEVSAVLAYANERRIPVTPFGAGSSLEGHIIPVQGGITLNLTMMNHIIDIRPDDFLAIVEPGVTRMQLNQALKKYGLFFPVDPGADATLGGMAATNASGTNSVKYGVMRDQVLGLEVVLADGKIVHTGGMAAKSSAGYDLTGLFVGSEGTLGVFTKMIVRLQGIPEATNAIKASFPTLTAAAQAAALLLKAGVSPGKIELVDEQTIQAVNQYKQTNYPEAPTLFIELSGSAASVKDGTEVVKEWCAAENAVSFETEDDPAGRAKLWEARHHAAFAIQAAHPGKTMLSTDVCVPVSKLPEAIAETRKLVDEYGITAAIFGHVGDGNYHTVLTFDPADAEEVKRVEEINARIVRYALSHGGTCTGEHGIGIGKRHFLYEEHRDSVPLMQGIKRLFDPNGIMNPGKIFL
>NC_014650.1|WP_003247739.1|251118_252096_+|alpha-ketoacid-dehydrogenase-subunit-beta
MAEKTMIQAINEAIRQEMERDERVIVLGEDVGKNGGVFRATDGLFEQFGDRRVFDTPLAESGIIGTSIGLAVNGFRPVAEIQFLGFAYQAMDQLAAQAARLRFRSAGRFTCPLVVRSPYGGGVRTPELHSDALEALFTHSPGLKVVMPSNAFDAKGLLISAIRDEDPVLFLEPMKLYRALRMEVPDEPYEIPLGTARVVKEGEDVTIISWGATVPLVAKLAEEMKEKGIDAEVIDLRSLQPLDIDAIVQSVEKTGRVMVVHEAVKTNGFGAEIAALISERALFSLSAPIVRVTGYDTPYPVPSVEDEWLPNAARIVEGVQMLMRY
>NC_014650.1|WP_013399886.1|264899_266288_-|LLM-class-flavin-dependent-oxidoreductase
MAKQIILNAFEMASAMHNSHGLWKHPESKRQRGYKDIEYWIKMAKLLERGKFDAVFFADVLGVYDTYRQSKAPSIRDGLQFPVNDASLVIPVMASVTKHLSFALTVSTTYEHPFNIARRFSTLDHLTKGRIAWNVVTSYLPNAARNFGLPEMIKHDQRYDIADEFLEVTYKLWEGSWEDDAFIEDKQNGILIDPDKVHEIHHAGKFFAVEGPHLCEPSPQRTPVIYQAGTSERGREFAAKHAECVFVGGPTPERIKYYTNDIKRRAEKYGRNPDNIKVFAFLTVIVGKTTEEAEQKFAELNHLWSPDASKAQFSGASGYDLAEYETKDLNAPFEFKNTEHGHYKAASLTKDASKKLSIGEALSKLEQLDRESIIVGNPEEVADAIQHRFEESGVDGFNLNHLITPSSLEDFIELVIPILQKRGLYKTEYKPGTLREKLFNYGSSLLPEDHPGSAYRSKSFIV
>NC_014650.1|WP_013399887.1|266335_267166_-|hypothetical-protein
MKAHKILFSFIALAFLVLSGCSSLTQNTNSSATKTIKLGATAGPYSDQIKKVIKPYLEKKGYKVELIEFNDYVQPNISLDQGSIDANVFQNEVYMKNFEKTRNMELYEVIKIPTAPIGIYSKKHKSLDEIKDGTTIALPNEPVNQARALTMLEQLGLIQLKKGVDPIKVSERDIEKYHKKIVLKPLEPAQLPRSLGDVDYSLINGNFAISSGLKLKDAVALEKTPPYYLNGVTVREKDKDAAFVKDIVEAYKSKEFRKLMKEDEEYQGYAWPDWFK
>NC_014650.1|WP_003247760.1|267210_267876_-|ABC-transporter-permease
MLLDALIRLIPELNKAFLETIYMVAISLFAAVVAGLPLGILLFVTDRGLFLENIAVKSVLGFIVNMIRSIPFIILLVGLLPLTKLITGTTIGPTAASVSLSVAAVPFFARIVETSLREIEKGVIEAAIAVGATPWMIIKDVLLPETRPGIVHGITITTISLVGYSAMAGIVGGGGIGDLAIRFGYYRYDNTIMITTIVILICLVQIIQFIGDRIARLVDKR
>NC_014650.1|WP_013399888.1|267865_268879_-|methionine-ABC-transporter-ATP-binding-protein
MIEIKNVTKIYSTKKKQVVGVDNISLTIQDGEIFGIIGYSGAGKSTLLRCLNLLERPTSGQVIIDGVDLTSLNDKQLRQARLKIGMIFQHFYLVSSKTVFENVAFALKAAKKPKEEIEKRVNELLEMVGLSDKRDAYPSQLSGGQKQRVGIARALANDPTVLLCDEATSALDPSTTKSILALLKKINRELGITIVLITHEMEVVKEICDRVAVMQNGRIIELGTVYDIFTNPQEELTKSFINSVLRFEIPDHLLQKRTGTMVKIHFKGEIAEEAVISDMLQSFKVKGNILHGKIEYIQEIPLGIFVMELIGEQEEIQRAIDYISQRTNALEVIAYAA
>NC_014650.1|WP_013399889.1|268956_270282_-|acyl-CoA/acyl-ACP-dehydrogenase
MLRNSQSSGTSFLLPLFNWAHAKECIAGQKYKKGEIMLSIASKKTHRSYLSDELSRKFVQNERQEFLLHLASELAEQFHETADIIDQEGRFPFENFQKLKDCNYQSLTVPKQYGGEEISLYEFLLMQERLSQGDASTALCIGWHLGVIYDLRERQTWDSEKFKWLCHEVVQNKVLINRVATENGTGSPTRGGKPETVAVKRNGKWVITGRKSFASMAIALDYSLVTATIQESGKVGSFLVDHRLQGVSVEETWDMIGMRGTRSDDLVLDQVELPEDALVELDQLESPKGNMGRAWLLHVPACFLGIAIAARNYAISFASEYQPNSLPGPIKDVPEVQRKIGEIDLELLKARHTLYSVAHRWDTYPEKRMEMSGELAAAKHIAVNSANKVVDLAMRIVGARSLQKSSPLQRYYRDVRAGLHNPPMDDAVISLLAKQALQSFH
>NC_014650.1|WP_003247766.1|270379_271708_-|LLM-class-flavin-dependent-oxidoreductase
MKKKQMKLGVFLMGTGHHIASWRHPHVQADGCEDFAFFHKIAKIAEKGKLDMLFLSDGLSFNELSHPAELVRFEPITLLAALSVVTSHIGLAATATTTYNEPFHIARKFSSLDHLSKGRAAWNVVTSYYEDEAKNFSQDAHLDHHLRYERAKEFVEVVKGLWDSWEKDALVRDKQSGVYFDPKKLHPLNHKGKYFSVKGPLNSSRSPQGRPVLIQAGSSEDGVNFAAQIADVIFTAQQTLEEAQHFYRKVKKKAAEFGRNPDEVIIMPGVSPYIGNTEQEAREKYEQLQELIVPEIGLAFLSDYLGGIDLSRYSLDDPLPDEIPETNGNKSRRKLIIDLARREHLTIGELYKRIAGSRGHRIIFGTPEQIADQLEEWIIHEGADGFNLMFPYYPDGLSEFVDQVIPILQERGLFRKEYEGTTLREHLGLPEPESRYSPAPSQ
>NC_014650.1|WP_003247768.1|271738_272515_-|aliphatic-sulfonate-ABC-transporter-permease-SsuC
MKKIRKIYDQIAPWIVPILLLIAWQLFSAIGWISERVLPSPLEVLLAAITLTKNGELFTNIGVSFTRAFIGFVIGGGIGLILGLLNGIYPVAEKYLNTTIQMFRNIPHLALIPIVILWFGVGEEAKIFLVIIGVFFPIYINTYHGVISVPKDLIEMGKVYGLSKWILFSNVIFPSALPSILVGLRYALGVMWLTLIVAETVAASSGIGYMAMNAREFMQLDVVVLSILLYALLGKLADSLAKCLERYFLKWNPAYQKK
>NC_014650.1|WP_013399890.1|272543_273512_-|aliphatic-sulfonate-ABC-transporter-substrate-binding-protein
MRSMKQSKHILWIIHFLVFSLLLSSCGKAEETGGKNKEIHIGYQKNGTTLLLKHKQELQKELEKEGYKVTWSEFNTGSSILEALNAGSIDFAGAGDIPSIFALEKGSNFNYIASEPSSPSSEGILVRKDSGIQSLEDLKGKRIAFNKASIAQYLLTKALDSAGLSMDDVEPVYLNPPEASIAFEQGEVDAWVVWDPYMTVAESKGHIILKDATGIVPYRTFYFSTPEIAKEHPEIVKKFVEHLSNIGKQINHDPTEAAALLQKATNIPAETWEKVLNNKKSDVHFMDEKAVRDLQTEADDLLKIGLIKKQVQIEDYVWYPEK
>NC_014650.1|WP_013399891.1|273577_274696_-|LLM-class-flavin-dependent-oxidoreductase
MVEFITMAPTSGDSTLVGLANNSSKLNSWTGTDENAERPPTQEYIKAIAQAAEKGGFSTLLLPTGTGCLDSLAVAANLIAYTSKLKFLFAIRPGFIAPTTFAKQFATVDYWSNGRALVNIVTGGSPVELASEGDYLDHDTRYKRTREYMQILKKLFTEESVDYEGEFFTLKGASLFPKPVKTPPIYFGGASEIAKEVAAEEADVYMMWGETFENTKQRLEEMKQRAAKHNRTLSYSVSFQVILGNTEEEAWEKANKLISKVSASILAKKEEMIVKGDSIGAKRLHQLMESSKERNFQIGPNLWAGLTQVLSGNSIALVGTPEQIAERIVELVELGFDKVLLRGFPHLETIEQLGELVIPKVREKLAQKQLVK
>NC_014650.1|WP_013399892.1|274806_275586_-|ATP-binding-cassette-domain-containing-protein
MPETSGVALSIHQLEKSFGHLHVLRKIDLQIASGEFVAIVGKSGCGKSTLLRLIAGLEKATSGEIRQNGKTIKELNPQARIMFQEARLLPWRSVLENVGVGLRLQKDWKQRAIWALKQVGLEERAHDWPSVLSGGQKQRVSLARALAAQPQLLLLDEPLGALDALTRMEMQALIEEIWQQQKFTALLVTHDVNEAITLADRVVLIEKGTIKMDLPIPLPRPRNRSDSAFIELEENVLAHVLEKTSLKKETENLKSAANE

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Crispr_ID: NC_014650_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014650_4

590652-591942

Orphan

Consensus_repeat	Method
GTTTCAATTCCTTATAGGTAAGATACAAAC	CRISPRCasFinder
GTTTCAATTCCTTATAGGTAAGATACAAAC	CRT
GTTTGTATCTTACCTATAAGGAATTGAAAC	PILER-CR

19 spacers

The CRISPR arrays of NC_014650_4

>merge|NC_014650|4|590652-591942|CRISPRCasFinder,CRT,PILER-CR
GGTTTTAATCCTTATAGGTAAGATGCAAACTGCTTGCAGATTGGCATCCAGACATTATTGAGTTTAGTTTCAATTCCTTATAGGTAAGATACAAACGCGCAGCCCTTAAGAAACTCCCCAGGCTTATACGGAAGTTTCAATTCCTTATAGGTAAGATACAAACAATAGAAAGATGCAAGAACAAGACCTATTCGACCCTAGTTTCAATTCCTTATAGGTAAGATACAAACTATTTGAGCCGACTTCCGCCAGTTCTTTGAGGTCAGTTTCAATTCTTTATAGGTAAGATACAAACTTTTTCTGGCGTACTTCGTTGCGCTCGTTGTGGACGAGGTTTCAATTCCTTATAGGTAAGATACAAACAATATTAGGCCATTACCTTTTGATTTTGCGATATTGTTTCAATTCCTTATAGGTAAGATACAAACGAACACGATTGGCTTTTGTTTTCTGTAGCGTTCGTGTTTCAATTCCTTATAGGTAAGATACAAACTCATCGAACTTCGCTGTCGGATACAAAGCTTTCAGGTTTCAATTCCTTATAGGTAAGATACAAACGAATTGCCTATTGGGCTGCGGAAAAGGGACTAAAACAGTTTCAATTCCTTATAGGTAAGATACAAACAATTCTAATCCCATATGGTGAATGGGCATTAAATATGTTTCAATTCCTTATAGGTAAGATACAAACTTGCGATTCTTGACGAAATGGTAAAAGAATATTCGGCGTTTCAATTCCTTATAGGTAAGATACAAACTGCTTTGAAACATTGTCCTAACGGCATGCCTTTGCTTATGTTTCAATTCCTTATAGGTAAGATACAAACCAAGTTAGTGTCCTTTTTGCACTCATTGCAGTAGTCGTGTTTCAATTCCTTATAGGTAAGATACAAACCTATTATTATGGCACGCTCTATGGCATGGTATACGAGTTTCAATTCCTTATAGGTAAGATACAAACCGAAAAATCAAACCCGGCTGGTTTGTTTCGCCGGTGGTTTCAATTCCTTATAGGTAAGATACAAACGAATTCAATCAATGCTTTTTTAGATAGAATTTCAGGTTTCAATTCCTTATAGGTAAGATACAAACCACTTCTGACGCTTGTGCTTGCGCTACCTGTTGGTCGTTTCAATTCCTTATAGGTAAGATACAAACGATGAACGGTGAAAAGCAGATGAAATCATTATCCGTTGTTTCAATTCCTTATAGGTAAGATACAAACCTCGGAGGGATTGGTTGGGGCATTCGGATTGAGTTGGTTTCAATTCCTTATAGGTAAGATACAAAC

>NC_014650|4|4|590652-591942|CRISPRCasFinder
GGTTTTAATCCTTATAGGTAAGATGCAAAC	TGCTTGCAGATTGGCATCCAGACATTATTGAGTTTA
GTTTCAATTCCTTATAGGTAAGATACAAAC	GCGCAGCCCTTAAGAAACTCCCCAGGCTTATACGGAA
GTTTCAATTCCTTATAGGTAAGATACAAAC	AATAGAAAGATGCAAGAACAAGACCTATTCGACCCTA
GTTTCAATTCCTTATAGGTAAGATACAAAC	TATTTGAGCCGACTTCCGCCAGTTCTTTGAGGTCA
GTTTCAATTCTTTATAGGTAAGATACAAAC	TTTTTCTGGCGTACTTCGTTGCGCTCGTTGTGGACGAG
GTTTCAATTCCTTATAGGTAAGATACAAAC	AATATTAGGCCATTACCTTTTGATTTTGCGATATT
GTTTCAATTCCTTATAGGTAAGATACAAAC	GAACACGATTGGCTTTTGTTTTCTGTAGCGTTCGT
GTTTCAATTCCTTATAGGTAAGATACAAAC	TCATCGAACTTCGCTGTCGGATACAAAGCTTTCAG
GTTTCAATTCCTTATAGGTAAGATACAAAC	GAATTGCCTATTGGGCTGCGGAAAAGGGACTAAAACA
GTTTCAATTCCTTATAGGTAAGATACAAAC	AATTCTAATCCCATATGGTGAATGGGCATTAAATAT
GTTTCAATTCCTTATAGGTAAGATACAAAC	TTGCGATTCTTGACGAAATGGTAAAAGAATATTCGGC
GTTTCAATTCCTTATAGGTAAGATACAAAC	TGCTTTGAAACATTGTCCTAACGGCATGCCTTTGCTTAT
GTTTCAATTCCTTATAGGTAAGATACAAAC	CAAGTTAGTGTCCTTTTTGCACTCATTGCAGTAGTCGT
GTTTCAATTCCTTATAGGTAAGATACAAAC	CTATTATTATGGCACGCTCTATGGCATGGTATACGA
GTTTCAATTCCTTATAGGTAAGATACAAAC	CGAAAAATCAAACCCGGCTGGTTTGTTTCGCCGGTG
GTTTCAATTCCTTATAGGTAAGATACAAAC	GAATTCAATCAATGCTTTTTTAGATAGAATTTCAG
GTTTCAATTCCTTATAGGTAAGATACAAAC	CACTTCTGACGCTTGTGCTTGCGCTACCTGTTGGTC
GTTTCAATTCCTTATAGGTAAGATACAAAC	GATGAACGGTGAAAAGCAGATGAAATCATTATCCGTT
GTTTCAATTCCTTATAGGTAAGATACAAAC	CTCGGAGGGATTGGTTGGGGCATTCGGATTGAGTTG
GTTTCAATTCCTTATAGGTAAGATACAAAC

>NC_014650|4|2|590652-591942|CRT
GGTTTTAATCCTTATAGGTAAGATGCAAAC	TGCTTGCAGATTGGCATCCAGACATTATTGAGTTTA
GTTTCAATTCCTTATAGGTAAGATACAAAC	GCGCAGCCCTTAAGAAACTCCCCAGGCTTATACGGAA
GTTTCAATTCCTTATAGGTAAGATACAAAC	AATAGAAAGATGCAAGAACAAGACCTATTCGACCCTA
GTTTCAATTCCTTATAGGTAAGATACAAAC	TATTTGAGCCGACTTCCGCCAGTTCTTTGAGGTCA
GTTTCAATTCTTTATAGGTAAGATACAAAC	TTTTTCTGGCGTACTTCGTTGCGCTCGTTGTGGACGAG
GTTTCAATTCCTTATAGGTAAGATACAAAC	AATATTAGGCCATTACCTTTTGATTTTGCGATATT
GTTTCAATTCCTTATAGGTAAGATACAAAC	GAACACGATTGGCTTTTGTTTTCTGTAGCGTTCGT
GTTTCAATTCCTTATAGGTAAGATACAAAC	TCATCGAACTTCGCTGTCGGATACAAAGCTTTCAG
GTTTCAATTCCTTATAGGTAAGATACAAAC	GAATTGCCTATTGGGCTGCGGAAAAGGGACTAAAACA
GTTTCAATTCCTTATAGGTAAGATACAAAC	AATTCTAATCCCATATGGTGAATGGGCATTAAATAT
GTTTCAATTCCTTATAGGTAAGATACAAAC	TTGCGATTCTTGACGAAATGGTAAAAGAATATTCGGC
GTTTCAATTCCTTATAGGTAAGATACAAAC	TGCTTTGAAACATTGTCCTAACGGCATGCCTTTGCTTAT
GTTTCAATTCCTTATAGGTAAGATACAAAC	CAAGTTAGTGTCCTTTTTGCACTCATTGCAGTAGTCGT
GTTTCAATTCCTTATAGGTAAGATACAAAC	CTATTATTATGGCACGCTCTATGGCATGGTATACGA
GTTTCAATTCCTTATAGGTAAGATACAAAC	CGAAAAATCAAACCCGGCTGGTTTGTTTCGCCGGTG
GTTTCAATTCCTTATAGGTAAGATACAAAC	GAATTCAATCAATGCTTTTTTAGATAGAATTTCAG
GTTTCAATTCCTTATAGGTAAGATACAAAC	CACTTCTGACGCTTGTGCTTGCGCTACCTGTTGGTC
GTTTCAATTCCTTATAGGTAAGATACAAAC	GATGAACGGTGAAAAGCAGATGAAATCATTATCCGTT
GTTTCAATTCCTTATAGGTAAGATACAAAC	CTCGGAGGGATTGGTTGGGGCATTCGGATTGAGTTG
GTTTCAATTCCTTATAGGTAAGATACAAAC

>NC_014650|4|2|590718-591942|PILER-CR
GTTTCAATTCCTTATAGGTAAGATACAAAC	GCGCAGCCCTTAAGAAACTCCCCAGGCTTATACGGAA
GTTTCAATTCCTTATAGGTAAGATACAAAC	AATAGAAAGATGCAAGAACAAGACCTATTCGACCCTA
GTTTCAATTCCTTATAGGTAAGATACAAAC	TATTTGAGCCGACTTCCGCCAGTTCTTTGAGGTCA
GTTTCAATTCTTTATAGGTAAGATACAAAC	TTTTTCTGGCGTACTTCGTTGCGCTCGTTGTGGACGAG
GTTTCAATTCCTTATAGGTAAGATACAAAC	AATATTAGGCCATTACCTTTTGATTTTGCGATATT
GTTTCAATTCCTTATAGGTAAGATACAAAC	GAACACGATTGGCTTTTGTTTTCTGTAGCGTTCGT
GTTTCAATTCCTTATAGGTAAGATACAAAC	TCATCGAACTTCGCTGTCGGATACAAAGCTTTCAG
GTTTCAATTCCTTATAGGTAAGATACAAAC	GAATTGCCTATTGGGCTGCGGAAAAGGGACTAAAACA
GTTTCAATTCCTTATAGGTAAGATACAAAC	AATTCTAATCCCATATGGTGAATGGGCATTAAATAT
GTTTCAATTCCTTATAGGTAAGATACAAAC	TTGCGATTCTTGACGAAATGGTAAAAGAATATTCGGC
GTTTCAATTCCTTATAGGTAAGATACAAAC	TGCTTTGAAACATTGTCCTAACGGCATGCCTTTGCTTAT
GTTTCAATTCCTTATAGGTAAGATACAAAC	CAAGTTAGTGTCCTTTTTGCACTCATTGCAGTAGTCGT
GTTTCAATTCCTTATAGGTAAGATACAAAC	CTATTATTATGGCACGCTCTATGGCATGGTATACGA
GTTTCAATTCCTTATAGGTAAGATACAAAC	CGAAAAATCAAACCCGGCTGGTTTGTTTCGCCGGTG
GTTTCAATTCCTTATAGGTAAGATACAAAC	GAATTCAATCAATGCTTTTTTAGATAGAATTTCAG
GTTTCAATTCCTTATAGGTAAGATACAAAC	CACTTCTGACGCTTGTGCTTGCGCTACCTGTTGGTC
GTTTCAATTCCTTATAGGTAAGATACAAAC	GATGAACGGTGAAAAGCAGATGAAATCATTATCCGTT
GTTTCAATTCCTTATAGGTAAGATACAAAC	CTCGGAGGGATTGGTTGGGGCATTCGGATTGAGTTG
GTTTCAATTCCTTATAGGTAAGATACAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_014650.1\|WP_003248349.1\|582409_582613_+\|hypothetical-protein	unknown	unknown	unknown
NC_014650.1\|WP_003248367.1\|592607_593603_-\|potassium-channel-protein	unknown	unknown	gnl\|CDD\|236711
NC_014650.1\|WP_013400088.1\|587147_587381_-\|DUF378-domain-containing-protein	unknown	unknown	gnl\|CDD\|377214
NC_014650.1\|WP_013400094.1\|597306_597564_+\|hypothetical-protein	unknown	unknown	unknown
NC_014650.1\|WP_013400091.1\|594190_595474_+\|purine/pyrimidine-permease	unknown	unknown	gnl\|CDD\|183124
NC_014650.1\|WP_041269299.1\|584576_584840_+\|DUF1871-family-protein	unknown	unknown	gnl\|CDD\|370210
NC_014650.1\|WP_003248362.1\|587534_588698_+\|iron-containing-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|341466
NC_014650.1\|WP_003248351.1\|582685_583210_+\|superoxide-dismutase-family-protein	unknown	unknown	gnl\|CDD\|238186
NC_014650.1\|WP_003248366.1\|592206_592611_+\|YugN-like-family-protein	unknown	unknown	gnl\|CDD\|370164
NC_014650.1\|WP_003248353.1\|583325_584486_-\|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl\|CDD\|224090
NC_014650.1\|WP_003248364.1\|588857_590207_+\|glucose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|184504
NC_014650.1\|WP_013400096.1\|599853_600612_+\|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl\|CDD\|119407
NC_014650.1\|WP_013400093.1\|596757_597246_+\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|224168
NC_014650.1\|WP_013400095.1\|597684_598626_-\|thermonuclease-family-protein	unknown	unknown	gnl\|CDD\|214615
NC_014650.1\|WP_013400090.1\|593730_593916_+\|H-type-small-acid-soluble-spore-protein	unknown	unknown	gnl\|CDD\|377962
NC_014650.1\|WP_003248357.1\|584954_585455_+\|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
NC_014650.1\|WP_013400087.1\|585451_586624_+\|aminotransferase	unknown	unknown	gnl\|CDD\|181082
NC_014650.1\|WP_003248361.1\|586744_587110_+\|general-stress-protein-13	unknown	unknown	gnl\|CDD\|181215
NC_014650.1\|WP_013400097.1\|600766_602227_-\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|143469
NC_014650.1\|WP_013400092.1\|595479_596658_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|341027

Protein	Function_ID	Function_description	E-value
NC_014650.1\|WP_013400097.1\|600766_602227_-\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|143469	cd07151, ALDH_HBenzADH, NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like. NADP+-dependent, p-hydroxybenzaldehyde dehydrogenase (PchA, HBenzADH) which catalyzes oxidation of p-hydroxybenzaldehyde to p-hydroxybenzoic acid and other related sequences are included in this CD.	0
NC_014650.1\|WP_003248367.1\|592607_593603_-\|potassium-channel-protein	gnl\|CDD\|236711	PRK10537, PRK10537, voltage-gated potassium channel protein.	1.25493e-16
NC_014650.1\|WP_013400088.1\|587147_587381_-\|DUF378-domain-containing-protein	gnl\|CDD\|377214	pfam04070, DUF378, Domain of unknown function (DUF378). Predicted transmembrane domain of unknown function. The majority of the family have two predicted transmembrane regions.	3.72143e-26
NC_014650.1\|WP_013400091.1\|594190_595474_+\|purine/pyrimidine-permease	gnl\|CDD\|183124	PRK11412, PRK11412, uracil/xanthine transporter.	1.81312e-62
NC_014650.1\|WP_041269299.1\|584576_584840_+\|DUF1871-family-protein	gnl\|CDD\|370210	pfam08958, DUF1871, Domain of unknown function (DUF1871). This set of hypothetical proteins is produced by prokaryotes pertaining to the Bacillus genus.	1.77163e-34
NC_014650.1\|WP_003248362.1\|587534_588698_+\|iron-containing-alcohol-dehydrogenase	gnl\|CDD\|341466	cd08187, BDH, Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process. The butanol dehydrogenase (BDH) is involved in the final step of the butanol formation pathway in anaerobic micro-organism. Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process. Activity in the reverse direction is 50-fold lower than that in the forward direction. The NADH-BDH has higher activity with longer chained aldehydes and is inhibited by metabolites containing an adenine moiety. This protein family belongs to the so-called iron-containing alcohol dehydrogenase superfamily. Since members of this superfamily use different divalent ions, preferentially iron or zinc, it has been suggested to be renamed to family III metal-dependent polyol dehydrogenases. This family also includes E. coli YqhD enzyme, an NADP-dependent dehydrogenase whose activity measurements with several alcohols demonstrate preference for alcohols longer than C3. The active site of YqhD contains a Zn metal, and a modified NADPH cofactor bearing OH groups on the saturated C5 and C6 atoms, possibly due to oxygen stress on the enzyme, which would functionally work under anaerobic conditions.	0
NC_014650.1\|WP_003248351.1\|582685_583210_+\|superoxide-dismutase-family-protein	gnl\|CDD\|238186	cd00305, Cu-Zn_Superoxide_Dismutase, Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the human SOD1 gene causes familial amyotrophic lateral sclerosis (Lou Gehrig's disease). Cytoplasmic and periplasmic SODs exist as dimers, whereas chloroplastic and extracellular enzymes exist as tetramers. Structure supports independent functional evolution in prokaryotes (P-class) and eukaryotes (E-class) [PMID:.8176730].	5.07068e-47
NC_014650.1\|WP_003248366.1\|592206_592611_+\|YugN-like-family-protein	gnl\|CDD\|370164	pfam08868, YugN, YugN-like family. This family of proteins related to B. subtilis YugN are functionally uncharacterized.	1.96652e-77
NC_014650.1\|WP_003248353.1\|583325_584486_-\|pyridoxal-phosphate-dependent-aminotransferase	gnl\|CDD\|224090	COG1168, MalY, Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism].	0
NC_014650.1\|WP_003248364.1\|588857_590207_+\|glucose-6-phosphate-isomerase	gnl\|CDD\|184504	PRK14097, pgi, glucose-6-phosphate isomerase; Provisional.	0
NC_014650.1\|WP_013400096.1\|599853_600612_+\|N-acetylmuramoyl-L-alanine-amidase	gnl\|CDD\|119407	cd02696, MurNAc-LAA, N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino acids in certain cell wall glycopeptides. These proteins are Zn-dependent peptidases with highly conserved residues involved in cation co-ordination. MurNAc-LAA in this family is one of several peptidoglycan hydrolases (PGHs) found in bacterial and bacteriophage or prophage genomes that are involved in the degradation of the peptidoglycan. In Escherichia coli, there are five MurNAc-LAAs present: AmiA, AmiB, AmiC and AmiD that are periplasmic, and AmpD that is cytoplasmic. Three of these (AmiA, AmiB and AmiC) belong to this family, the other two (AmiD and AmpD) do not. E. coli AmiA, AmiB and AmiC play an important role in cleaving the septum to release daughter cells after cell division. In general, bacterial MurNAc-LAAs are members of the bacterial autolytic system and carry a signal peptide in their N-termini that allows their transport across the cytoplasmic membrane. However, the bacteriophage MurNAc-LAAs are endolysins since these phage-encoded enzymes break down bacterial peptidoglycan at the terminal stage of the phage reproduction cycle. As opposed to autolysins, almost all endolysins have no signal peptides and their translocation through the cytoplasmic membrane is thought to proceed with the help of phage-encoded holin proteins. The amidase catalytic module is fused to another functional module (cell wall binding module or CWBM) either at the N- or C-terminus, which is responsible for high affinity binding of the protein to the cell wall.	3.75832e-66
NC_014650.1\|WP_013400093.1\|596757_597246_+\|N-acetyltransferase	gnl\|CDD\|224168	COG1247, COG1247, Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane].	2.03628e-56
NC_014650.1\|WP_013400095.1\|597684_598626_-\|thermonuclease-family-protein	gnl\|CDD\|214615	smart00318, SNc, Staphylococcal nuclease homologues.	8.4761e-22
NC_014650.1\|WP_013400090.1\|593730_593916_+\|H-type-small-acid-soluble-spore-protein	gnl\|CDD\|377962	pfam08141, SspH, Small acid-soluble spore protein H family. This family consists of the small acid-soluble spore proteins (SASP) of the H type (sspH). SspH are unique to spores of Bacillus subtilis and are expressed only in the forespore compartment during sporulation of this organism. The sspH genes are monocistronic and are recognized by the forespore-specific sigma factor for RNA polymerase - sigma-G. The specific role of this protein is unclear but is thought to play a role in sporulation under conditions different from that of the common laboratory tests of spore properties.	2.55553e-19
NC_014650.1\|WP_003248357.1\|584954_585455_+\|Lrp/AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	1.44506e-34
NC_014650.1\|WP_013400087.1\|585451_586624_+\|aminotransferase	gnl\|CDD\|181082	PRK07682, PRK07682, aminotransferase.	0
NC_014650.1\|WP_003248361.1\|586744_587110_+\|general-stress-protein-13	gnl\|CDD\|181215	PRK08059, PRK08059, general stress protein 13; Validated.	6.72299e-64
NC_014650.1\|WP_013400092.1\|595479_596658_-\|MFS-transporter	gnl\|CDD\|341027	cd17474, MFS_YfmO_like, Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily. This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.54057e-77

>NC_014650.1|WP_003248364.1|588857_590207_+|glucose-6-phosphate-isomerase
MTHIRFDYSKALAFFGEHELTYLRDAVKVAHHSLHEKTGVGNDFLGWIDLPVNYDKEEFARIQKAAAKIQADSDVLLVIGIGGSYLGARAAIEMLHHSFYNALSKEKRRTPQIIFVGNNISSTYMKDVMDLLEGKDFSINVISKSGTTTEPAIAFRIFRKLLEEKYGKEEARKRIYATTDRARGALKTLATAEGYETFIIPDDVGGRYSVLTAVGLLPIAVSGANIEEMMKGAAQAREDFSNSELEENAAYQYAAIRNILYNKGKTIELLINYEPALQYFAEWWKQLFGESEGKDQKGIFPASANFSTDLHSLGQYIQEGRRDLFETVLKVEKPRHELVIEAEENDLDGLNYLAGKTVDFVNTKAFEGTLLAHTDGGVPNLVITLPELNEYTFGYLVYFFEKACAMSGYLLGVNPFDQPGVEAYKVNMFALLGKPGYEEKKAELEKRLK
>NC_014650.1|WP_003248362.1|587534_588698_+|iron-containing-alcohol-dehydrogenase
MENFSFQNPTKLIFGKGQIEQLKEEIPRYGKKILLVYGGGSIKRNGLYDEVMNLLNELKVEVTELPGVEPNPRLSTVRKGVEICKTEGIEFLLAVGGGSVIDCTKAIAAGAKYDGDPWDFITKKVKVFEALPFGTVLTLAATGSEMNAGSVITNWETKEKYGWNSPATFPQFSILDPTYTLTVPRDHTVYGIVDMMSHVFEQYFHHTANTPLQDRMCEAVLRTVMEAAPKLVNDLQNYELRETILYCGTIALNGLLQMGLRGDWATHNIEHAVSAVYDIPHAGGLAILFPNWMKHVLDENVSRFAQLAVRVFDVNPEGKAERDVALEGIEKLREFWSSIGAPSRLADYGIGEESLELIADKAMANGEFGKFKKLNRDDVLAILRASL
>NC_014650.1|WP_013400088.1|587147_587381_-|DUF378-domain-containing-protein
MNALQRIALLLTIIGAINWGLIGFFQFDLVAAIFGGQDSVLSRIIYGLVGIAGLINLALLFKPAEELGRTEPKASRT
>NC_014650.1|WP_003248361.1|586744_587110_+|general-stress-protein-13
MSNIEVGSIVKGKVTGIQPYGVFVELDRETQGLVHISEISHGFVKNIKDYVNVGDEITVKVLSIDPHTKRASLSMRAVEEGQRNMRKRHVKVKMSLNPGFHTLKEKLQEWIEQSKKEDLSK
>NC_014650.1|WP_013400087.1|585451_586624_+|aminotransferase
MMQQTKKSYVSETVARLKPSGIRRFFDLASSMEGVVSLGVGEPDFVTSWSIREASILSLEQGYTSYTANAGLLELRQEIAAYLARKFHVEYDPEAEILVTVGASQAIDLALRATVNPGDEVIVVEPSFVSYGPLVTLAGGVPVPVGTTGEDHFKLRPDQIERVITDRTKALIVCSPNNPTGTVLHKEDLEAIAQIVKKHDLLVISDEIYAELTYDEPYISFAAVDGMRERTILVSGFSKGFAMTGWRLGFTAAPAEILQAMLKIHQYAIMCAPTMAQYAAIEALRNGEQDVEYMKKSYRRRRNYFVQSLNEIGLSCHMPGGAFYAFPSIRATGLTSEQFAEKLLLEEKVAVVPGSVFGAGGEGYIRCSYASSMEQLQEAIKRIKRFLERL
>NC_014650.1|WP_003248357.1|584954_585455_+|Lrp/AsnC-family-transcriptional-regulator
MKLTEKEIEIIEILEKDARIPTETLAKMVSLSVDETEAILKKLEETKVIVQYTALVDWRKVDGHEGVTAMIDVKVTPKRGVGFDEVAERIYRFPEVKSVYLMSGAYDLSVVIEGRSMSEIANFVSEKLSTLDSVISTTTHFILKKYKHDGTVFDQGDQDHRIVMAP
>NC_014650.1|WP_041269299.1|584576_584840_+|DUF1871-family-protein
MDAQQVNWQLLHAIRAWDPFGYGNDAYETEAVDVLQAVHDCDEPTTLAGKIQAIYEFSFERKIPLNECIKMAKSLLAMKQAAACSLP
>NC_014650.1|WP_003248353.1|583325_584486_-|pyridoxal-phosphate-dependent-aminotransferase
MYSFDDVIDRRNTHSLKWDATERIFGVKDVLPMWVADMDFPAPPAVIEALNKRVEHGIFGYTIIPDSLKNAVKHWLQSRHQWEIETSWLSFSTGVIPAIATAIEAFTNEEDRIVVLTPVYPPLFQLVKKHRRTLVTSSLRLAETQYEIDWDDFEEKIRGAKLLVLCSPHNPGGRVWTKEELIKIGELCVEHGVIVISDEIHADLTLPPYQHVPFASIDPAFAEKSVTCIAPTKTFNLAGLQAAAAIIPNETLKRQFNNVQQRQGILTLNTFAVAGAEAAYQHGGEWLDALLPYLQKNINRLCSYIETNLPKLRVIRPEATYLVWVDCRPLGKTERQLKQLLLEKGKIAVEFGSKFGEEGRGFIRINIACPQKTLEDALHRLTAALQ
>NC_014650.1|WP_003248351.1|582685_583210_+|superoxide-dismutase-family-protein
MFQKAGLLFAAAVLFAVGCQKENVTNLEVNMINSAGDSIGTVKLTEQAKGVKLKLDLEGLPPGEHAIHIHEKGVCKKPDFQSAGNHYNPDGKKHGLLHPEGAHAGDLPNIIVKEDGTVNTELTAPNVTLKEGKKGTLLTKDGTAIVIHAGKDDGMTQPAGDAGERIACGEIKNR
>NC_014650.1|WP_003248349.1|582409_582613_+|hypothetical-protein
MAVSYILSFMLYFPEDKREYIPAAVTCMIFLIAAILTTRLIIKISRYQEEKAKRLEEQLIRDNKNQE
>NC_014650.1|WP_003248366.1|592206_592611_+|YugN-like-family-protein
MIEIPSQLEGKTFPLFQLEQLLKPLGYTIGGNWDYDHGSFDYKIADEAGYQFLRVPFEAIDGQLDSHGTTVKLGRPFLLSHKYQSGVDDHAYAGNFGAAFNQFSEPQDPDAAVSEKYINVGKALVKDLENRLID
>NC_014650.1|WP_003248367.1|592607_593603_-|potassium-channel-protein
MKNWDVFISYLRLPVFMRLLIIGTIMIVIFGTLIHFVEPATFRHVFDGIWWAIVTAATIGYGDMVPKTVAGKIVAISLILLGTGVITTYFASLSAAAVAKESALSNGQLRYMQKGHIIIVGWNERAREVIAKLSEYTPPVRCVIIDATLNELPVPFKNVHFIKGNPSYDDVLHKANATEAQMILITANQHKSEADADKDSILTLLAVKGIHPSIYAIVEILTEQNVNNAKRAGADEVIQTNLLASFTMANSLQSPGVSKAIIELLHQLHGKKLQLIAAEGPLIGKTFLESSEMLLDKRMILIGVMREEEGYINPSPHFLIEKGDRLFVITP
>NC_014650.1|WP_013400090.1|593730_593916_+|H-type-small-acid-soluble-spore-protein
MDINRVKQIVSSPADIPVYYNGVSVWIDDYNEQEETATIHLRDGHLREQREVPVEELTEKQ
>NC_014650.1|WP_013400091.1|594190_595474_+|purine/pyrimidine-permease
MRQVISSLQWFLFIISGSIVVPVTVASLYQLETADAMAFISRTFFVLAVAGLLQTAFGHRLPLNEGPAGIWWGIFILYASFGVALYGSRAETLRVLESALIMSGILFMLLSLLGIVDRLARLFTPTVTGTYLLLLAVQLSGSFLKGLLGVDETGKVSIVVAALSTIIIFLSLWMTNHPVLRQFSIIVSMITGWILFRLFGFAPSIHWTEKWFEFPKWFAFGPPRWEWGIVPTAFFVTLLLLTNMLASMKVVESVMKAEKANAGNPSPKRAGFMMGISHMISGVLAAIGSVPISGAGSFITTSKITKRLPFVIACVLIMLMSLFMPAVSLFTAMPAAVGYAAIFPMFAGMITLGLKELEQNGGWKERAEQVSLPLFTGIGVMFVPSEAFAPLPPVIASVASNGLIVGTLLSILLEAVAGKKGATSASK
>NC_014650.1|WP_013400092.1|595479_596658_-|MFS-transporter
MNRTAIVYLVSLAAFLGPFTQTIYTPILPEVTKDFGTSSFLVNLTISIFTFFLALMQMVYGPLTDTKGRRNVLLFGVFLYITASLGCFFSNSIYVLLVFRALQAIGIAAGSVVAATVIGDLFEGKARGKAMGTFQMMVSLGPVAGPIVGGFLGGRFNFHSVFLVLVLAGLLIWVGNFIFLQETKPEKQLAKTFRLRDFIPILRHRTGSSIILLGFIQYYAMYNFLVFLPSILTERYGLSAEEKGIAYLAMSCMIVIGSFIGGRIQGHWQERHIILATSYLNVASILLFLIVSHISISLLLISIMLFGLFLGTSLPVQTTLLTYVFQANRSTAIGVYNFFRYMGMALGPMIGSLLFSLGGYALVYGFTDIGFFFFSLWLTARVMFMNRPTSSI
>NC_014650.1|WP_013400093.1|596757_597246_+|N-acetyltransferase
MIRNANIEDLPAIVQIYNETIPSRMVTADLEPVTVESRKAWFFNHDPHTRPLWVVELDGHVRAWLSFQSFYGRPAYRHTAEISIYISGAYRGKGIGKQLLQKAVEEAPSLDIKTLLGFIFAHNEPSLRLFMRFGFETWGHLPKVAELDGIERDLLIVGKRMV
>NC_014650.1|WP_013400094.1|597306_597564_+|hypothetical-protein
MNVMPIRLFTIQDGEGFVADAFQCPVTGNLIYKSSGTPSVIAYNALTEEQIQYLEKYGFRRMNGASAAAASSPGSSTLEELLPEQ
>NC_014650.1|WP_013400095.1|597684_598626_-|thermonuclease-family-protein
MKKFVSALAIIVSTAIFPGNSFAHPGALDKLGGHFRKSDCTYLLHEPTPIAMQAKDKAALAQLIKKYNSNSECVRQLTLDKIDLQGHTLGGTSSSAASSPKQSTNQSSSLQLGQKYPAKLVTCIDGDTARFMVNGREYTTRFLFIDTPESTIQVEPYGKEASRFTCSRLSRGDITLETDGSTLFDKYRRLLAWVWVGDKLLQEEIAKAGLVEDFYDYGDYKYEDRIRKAMDEAKQAGAGMYGASSPKMNSADQQTKSEGQKPDIPSPDNEQKNQQADQETTAKETSDSNTELPVFYLLVFAFIVAFFYFLSRK
>NC_014650.1|WP_013400096.1|599853_600612_+|N-acetylmuramoyl-L-alanine-amidase
MVKIFIDPGHGGADPGAIGNGLQEKNVTLQIAVRVRDILLAEYDNVSIRMSRIGDQTVSLTERTAAANTWGADFYLSIHVNSGGGTGYEDYVYPGVGSPTTTYQKNIHEEIIKLVDFLDRGMKQANFFVLRETNMPAVLTENGFIDNANDAAKLKSSSFIENIARGHVNGIVRSFGLPKKSAGTLYKVQIGAFRVKTNADHLAAKAKAKGFNVYVIYKDGLYKVQIGAFANLENAKQLAEKAKAAGFEAIII
>NC_014650.1|WP_013400097.1|600766_602227_-|aldehyde-dehydrogenase-family-protein
MVNFKLLNKQYISGEWKDGTSNRQLIDFNPYNNEVITTFTCASLKDVDEAYRSAKEAQKKWQHTNPIEKRAVFENAVKYIEENKESIENIIIDELGGTKLKAAFEIDLVINIIKEAATYPFRMEGKILPSPVDGKENRLYRIPVGVVGVISPFNFPFFLSMKSVAPALGAGNGVVLKPHEHTPITGGTLIAKIFEEAGLPKGLLNVVITEIEEIGDGFIEHPIPKVISFTGSSKVGKHIGEVAGRHLKKVSLELGGNSALIVLDDADIDLAVSAAVFSRFTHQGQICMSANRIIVHEKVYDEFLTKYVRKVASLKCGDPRDPETIIGPLMNERQVQMIINLIETGIKEGATPILKGEVKGNIVEPVIFTDVTPDMTIAKEELFGPVVCIMKVENDQQAIEYANNSDFGLSGAIHTSNIERGAEMAKQIETGMIHINDGTINDEPIVAFGGEKNSGLGRLNGSWSLDAFTTVKWISIQHTPRKYPYS

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Crispr_ID: NC_014650_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014650_5

599147-599246

Orphan

Consensus_repeat	Method
AGTAACCAGCCAACACTAGCTCCTAACCAGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014650_5

>merge|NC_014650|5|599147-599246|CRISPRCasFinder
AGTAACCAGCCAACACTAGCTCCTAACCAGGCTTTGACTTCATACTGATTTCGCAGACTGACAAACAGAGTAACCAGCCAACACTAGCTCCTAACCAGGC

>NC_014650|5|5|599147-599246|CRISPRCasFinder
AGTAACCAGCCAACACTAGCTCCTAACCAGGC	TTTGACTTCATACTGATTTCGCAGACTGACAAACAG
AGTAACCAGCCAACACTAGCTCCTAACCAGGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_014650.1\|WP_003248367.1\|592607_593603_-\|potassium-channel-protein	unknown	unknown	gnl\|CDD\|236711
NC_014650.1\|WP_013400099.1\|606528_607299_+\|alanyl-tRNA-editing-protein	unknown	unknown	gnl\|CDD\|225427
NC_014650.1\|WP_013400094.1\|597306_597564_+\|hypothetical-protein	unknown	unknown	unknown
NC_014650.1\|WP_013400091.1\|594190_595474_+\|purine/pyrimidine-permease	unknown	unknown	gnl\|CDD\|183124
NC_014650.1\|WP_013400093.1\|596757_597246_+\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|224168
NC_014650.1\|WP_003248362.1\|587534_588698_+\|iron-containing-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|341466
NC_014650.1\|WP_003248366.1\|592206_592611_+\|YugN-like-family-protein	unknown	unknown	gnl\|CDD\|370164
NC_014650.1\|WP_013400097.1\|600766_602227_-\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|143469
NC_014650.1\|WP_003248364.1\|588857_590207_+\|glucose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|184504
NC_014650.1\|WP_013400096.1\|599853_600612_+\|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl\|CDD\|119407
NC_014650.1\|WP_013400095.1\|597684_598626_-\|thermonuclease-family-protein	unknown	unknown	gnl\|CDD\|214615
NC_014650.1\|WP_013400090.1\|593730_593916_+\|H-type-small-acid-soluble-spore-protein	unknown	unknown	gnl\|CDD\|377962
NC_014650.1\|WP_013400037.1\|607433_608669_-\|IS256-family-transposase	unknown	unknown	gnl\|CDD\|307151
NC_014650.1\|WP_003248384.1\|602247_603120_-\|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl\|CDD\|214599
NC_014650.1\|WP_013400098.1\|604198_606022_+\|APC-family-permease	unknown	unknown	gnl\|CDD\|372624
NC_014650.1\|WP_013400101.1\|610195_611395_-\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271189
NC_014650.1\|WP_013400102.1\|611425_611575_-\|Arm-DNA-binding-domain-containing-protein	unknown	unknown	unknown
NC_014650.1\|WP_158306615.1\|609815_609911_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|375704
NC_014650.1\|WP_013400100.1\|609095_609545_-\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|240044
NC_014650.1\|WP_013400092.1\|595479_596658_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|341027

Protein	Function_ID	Function_description	E-value
NC_014650.1\|WP_003248367.1\|592607_593603_-\|potassium-channel-protein	gnl\|CDD\|236711	PRK10537, PRK10537, voltage-gated potassium channel protein.	1.25493e-16
NC_014650.1\|WP_013400099.1\|606528_607299_+\|alanyl-tRNA-editing-protein	gnl\|CDD\|225427	COG2872, COG2872, Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only].	1.02708e-85
NC_014650.1\|WP_013400101.1\|610195_611395_-\|site-specific-integrase	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	7.74859e-50
NC_014650.1\|WP_013400091.1\|594190_595474_+\|purine/pyrimidine-permease	gnl\|CDD\|183124	PRK11412, PRK11412, uracil/xanthine transporter.	1.81312e-62
NC_014650.1\|WP_013400093.1\|596757_597246_+\|N-acetyltransferase	gnl\|CDD\|224168	COG1247, COG1247, Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane].	2.03628e-56
NC_014650.1\|WP_003248362.1\|587534_588698_+\|iron-containing-alcohol-dehydrogenase	gnl\|CDD\|341466	cd08187, BDH, Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process. The butanol dehydrogenase (BDH) is involved in the final step of the butanol formation pathway in anaerobic micro-organism. Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process. Activity in the reverse direction is 50-fold lower than that in the forward direction. The NADH-BDH has higher activity with longer chained aldehydes and is inhibited by metabolites containing an adenine moiety. This protein family belongs to the so-called iron-containing alcohol dehydrogenase superfamily. Since members of this superfamily use different divalent ions, preferentially iron or zinc, it has been suggested to be renamed to family III metal-dependent polyol dehydrogenases. This family also includes E. coli YqhD enzyme, an NADP-dependent dehydrogenase whose activity measurements with several alcohols demonstrate preference for alcohols longer than C3. The active site of YqhD contains a Zn metal, and a modified NADPH cofactor bearing OH groups on the saturated C5 and C6 atoms, possibly due to oxygen stress on the enzyme, which would functionally work under anaerobic conditions.	0
NC_014650.1\|WP_003248366.1\|592206_592611_+\|YugN-like-family-protein	gnl\|CDD\|370164	pfam08868, YugN, YugN-like family. This family of proteins related to B. subtilis YugN are functionally uncharacterized.	1.96652e-77
NC_014650.1\|WP_013400097.1\|600766_602227_-\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|143469	cd07151, ALDH_HBenzADH, NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like. NADP+-dependent, p-hydroxybenzaldehyde dehydrogenase (PchA, HBenzADH) which catalyzes oxidation of p-hydroxybenzaldehyde to p-hydroxybenzoic acid and other related sequences are included in this CD.	0
NC_014650.1\|WP_003248364.1\|588857_590207_+\|glucose-6-phosphate-isomerase	gnl\|CDD\|184504	PRK14097, pgi, glucose-6-phosphate isomerase; Provisional.	0
NC_014650.1\|WP_013400096.1\|599853_600612_+\|N-acetylmuramoyl-L-alanine-amidase	gnl\|CDD\|119407	cd02696, MurNAc-LAA, N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino acids in certain cell wall glycopeptides. These proteins are Zn-dependent peptidases with highly conserved residues involved in cation co-ordination. MurNAc-LAA in this family is one of several peptidoglycan hydrolases (PGHs) found in bacterial and bacteriophage or prophage genomes that are involved in the degradation of the peptidoglycan. In Escherichia coli, there are five MurNAc-LAAs present: AmiA, AmiB, AmiC and AmiD that are periplasmic, and AmpD that is cytoplasmic. Three of these (AmiA, AmiB and AmiC) belong to this family, the other two (AmiD and AmpD) do not. E. coli AmiA, AmiB and AmiC play an important role in cleaving the septum to release daughter cells after cell division. In general, bacterial MurNAc-LAAs are members of the bacterial autolytic system and carry a signal peptide in their N-termini that allows their transport across the cytoplasmic membrane. However, the bacteriophage MurNAc-LAAs are endolysins since these phage-encoded enzymes break down bacterial peptidoglycan at the terminal stage of the phage reproduction cycle. As opposed to autolysins, almost all endolysins have no signal peptides and their translocation through the cytoplasmic membrane is thought to proceed with the help of phage-encoded holin proteins. The amidase catalytic module is fused to another functional module (cell wall binding module or CWBM) either at the N- or C-terminus, which is responsible for high affinity binding of the protein to the cell wall.	3.75832e-66
NC_014650.1\|WP_013400095.1\|597684_598626_-\|thermonuclease-family-protein	gnl\|CDD\|214615	smart00318, SNc, Staphylococcal nuclease homologues.	8.4761e-22
NC_014650.1\|WP_013400090.1\|593730_593916_+\|H-type-small-acid-soluble-spore-protein	gnl\|CDD\|377962	pfam08141, SspH, Small acid-soluble spore protein H family. This family consists of the small acid-soluble spore proteins (SASP) of the H type (sspH). SspH are unique to spores of Bacillus subtilis and are expressed only in the forespore compartment during sporulation of this organism. The sspH genes are monocistronic and are recognized by the forespore-specific sigma factor for RNA polymerase - sigma-G. The specific role of this protein is unclear but is thought to play a role in sporulation under conditions different from that of the common laboratory tests of spore properties.	2.55553e-19
NC_014650.1\|WP_013400037.1\|607433_608669_-\|IS256-family-transposase	gnl\|CDD\|307151	pfam00872, Transposase_mut, Transposase, Mutator family.	2.13926e-156
NC_014650.1\|WP_003248384.1\|602247_603120_-\|methyl-accepting-chemotaxis-protein	gnl\|CDD\|214599	smart00283, MA, Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.	6.8879e-26
NC_014650.1\|WP_013400098.1\|604198_606022_+\|APC-family-permease	gnl\|CDD\|372624	pfam13520, AA_permease_2, Amino acid permease.	3.34391e-32
NC_014650.1\|WP_158306615.1\|609815_609911_+\|hypothetical-protein	gnl\|CDD\|375704	pfam18277, AbrB_C, AbrB C-terminal domain. This is the C-terminal domain of AbrB protein from Bacillus subtilis. AbrB is a transition state regulator. Functions of AbrB include biofilm formation, antibiotic production, competence development, extracellular enzyme production, motility, and sporulation. The C-terminal domain is responsible for multimerization and, to a lesser extent than the N-terminal domain, also contributes in DNA binding.	2.18364e-05
NC_014650.1\|WP_013400100.1\|609095_609545_-\|NUDIX-domain-containing-protein	gnl\|CDD\|240044	cd04688, Nudix_Hydrolase_29, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	1.85705e-34
NC_014650.1\|WP_013400092.1\|595479_596658_-\|MFS-transporter	gnl\|CDD\|341027	cd17474, MFS_YfmO_like, Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily. This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.54057e-77

>NC_014650.1|WP_013400095.1|597684_598626_-|thermonuclease-family-protein
MKKFVSALAIIVSTAIFPGNSFAHPGALDKLGGHFRKSDCTYLLHEPTPIAMQAKDKAALAQLIKKYNSNSECVRQLTLDKIDLQGHTLGGTSSSAASSPKQSTNQSSSLQLGQKYPAKLVTCIDGDTARFMVNGREYTTRFLFIDTPESTIQVEPYGKEASRFTCSRLSRGDITLETDGSTLFDKYRRLLAWVWVGDKLLQEEIAKAGLVEDFYDYGDYKYEDRIRKAMDEAKQAGAGMYGASSPKMNSADQQTKSEGQKPDIPSPDNEQKNQQADQETTAKETSDSNTELPVFYLLVFAFIVAFFYFLSRK
>NC_014650.1|WP_013400094.1|597306_597564_+|hypothetical-protein
MNVMPIRLFTIQDGEGFVADAFQCPVTGNLIYKSSGTPSVIAYNALTEEQIQYLEKYGFRRMNGASAAAASSPGSSTLEELLPEQ
>NC_014650.1|WP_013400093.1|596757_597246_+|N-acetyltransferase
MIRNANIEDLPAIVQIYNETIPSRMVTADLEPVTVESRKAWFFNHDPHTRPLWVVELDGHVRAWLSFQSFYGRPAYRHTAEISIYISGAYRGKGIGKQLLQKAVEEAPSLDIKTLLGFIFAHNEPSLRLFMRFGFETWGHLPKVAELDGIERDLLIVGKRMV
>NC_014650.1|WP_013400092.1|595479_596658_-|MFS-transporter
MNRTAIVYLVSLAAFLGPFTQTIYTPILPEVTKDFGTSSFLVNLTISIFTFFLALMQMVYGPLTDTKGRRNVLLFGVFLYITASLGCFFSNSIYVLLVFRALQAIGIAAGSVVAATVIGDLFEGKARGKAMGTFQMMVSLGPVAGPIVGGFLGGRFNFHSVFLVLVLAGLLIWVGNFIFLQETKPEKQLAKTFRLRDFIPILRHRTGSSIILLGFIQYYAMYNFLVFLPSILTERYGLSAEEKGIAYLAMSCMIVIGSFIGGRIQGHWQERHIILATSYLNVASILLFLIVSHISISLLLISIMLFGLFLGTSLPVQTTLLTYVFQANRSTAIGVYNFFRYMGMALGPMIGSLLFSLGGYALVYGFTDIGFFFFSLWLTARVMFMNRPTSSI
>NC_014650.1|WP_013400091.1|594190_595474_+|purine/pyrimidine-permease
MRQVISSLQWFLFIISGSIVVPVTVASLYQLETADAMAFISRTFFVLAVAGLLQTAFGHRLPLNEGPAGIWWGIFILYASFGVALYGSRAETLRVLESALIMSGILFMLLSLLGIVDRLARLFTPTVTGTYLLLLAVQLSGSFLKGLLGVDETGKVSIVVAALSTIIIFLSLWMTNHPVLRQFSIIVSMITGWILFRLFGFAPSIHWTEKWFEFPKWFAFGPPRWEWGIVPTAFFVTLLLLTNMLASMKVVESVMKAEKANAGNPSPKRAGFMMGISHMISGVLAAIGSVPISGAGSFITTSKITKRLPFVIACVLIMLMSLFMPAVSLFTAMPAAVGYAAIFPMFAGMITLGLKELEQNGGWKERAEQVSLPLFTGIGVMFVPSEAFAPLPPVIASVASNGLIVGTLLSILLEAVAGKKGATSASK
>NC_014650.1|WP_013400090.1|593730_593916_+|H-type-small-acid-soluble-spore-protein
MDINRVKQIVSSPADIPVYYNGVSVWIDDYNEQEETATIHLRDGHLREQREVPVEELTEKQ
>NC_014650.1|WP_003248367.1|592607_593603_-|potassium-channel-protein
MKNWDVFISYLRLPVFMRLLIIGTIMIVIFGTLIHFVEPATFRHVFDGIWWAIVTAATIGYGDMVPKTVAGKIVAISLILLGTGVITTYFASLSAAAVAKESALSNGQLRYMQKGHIIIVGWNERAREVIAKLSEYTPPVRCVIIDATLNELPVPFKNVHFIKGNPSYDDVLHKANATEAQMILITANQHKSEADADKDSILTLLAVKGIHPSIYAIVEILTEQNVNNAKRAGADEVIQTNLLASFTMANSLQSPGVSKAIIELLHQLHGKKLQLIAAEGPLIGKTFLESSEMLLDKRMILIGVMREEEGYINPSPHFLIEKGDRLFVITP
>NC_014650.1|WP_003248366.1|592206_592611_+|YugN-like-family-protein
MIEIPSQLEGKTFPLFQLEQLLKPLGYTIGGNWDYDHGSFDYKIADEAGYQFLRVPFEAIDGQLDSHGTTVKLGRPFLLSHKYQSGVDDHAYAGNFGAAFNQFSEPQDPDAAVSEKYINVGKALVKDLENRLID
>NC_014650.1|WP_003248364.1|588857_590207_+|glucose-6-phosphate-isomerase
MTHIRFDYSKALAFFGEHELTYLRDAVKVAHHSLHEKTGVGNDFLGWIDLPVNYDKEEFARIQKAAAKIQADSDVLLVIGIGGSYLGARAAIEMLHHSFYNALSKEKRRTPQIIFVGNNISSTYMKDVMDLLEGKDFSINVISKSGTTTEPAIAFRIFRKLLEEKYGKEEARKRIYATTDRARGALKTLATAEGYETFIIPDDVGGRYSVLTAVGLLPIAVSGANIEEMMKGAAQAREDFSNSELEENAAYQYAAIRNILYNKGKTIELLINYEPALQYFAEWWKQLFGESEGKDQKGIFPASANFSTDLHSLGQYIQEGRRDLFETVLKVEKPRHELVIEAEENDLDGLNYLAGKTVDFVNTKAFEGTLLAHTDGGVPNLVITLPELNEYTFGYLVYFFEKACAMSGYLLGVNPFDQPGVEAYKVNMFALLGKPGYEEKKAELEKRLK
>NC_014650.1|WP_003248362.1|587534_588698_+|iron-containing-alcohol-dehydrogenase
MENFSFQNPTKLIFGKGQIEQLKEEIPRYGKKILLVYGGGSIKRNGLYDEVMNLLNELKVEVTELPGVEPNPRLSTVRKGVEICKTEGIEFLLAVGGGSVIDCTKAIAAGAKYDGDPWDFITKKVKVFEALPFGTVLTLAATGSEMNAGSVITNWETKEKYGWNSPATFPQFSILDPTYTLTVPRDHTVYGIVDMMSHVFEQYFHHTANTPLQDRMCEAVLRTVMEAAPKLVNDLQNYELRETILYCGTIALNGLLQMGLRGDWATHNIEHAVSAVYDIPHAGGLAILFPNWMKHVLDENVSRFAQLAVRVFDVNPEGKAERDVALEGIEKLREFWSSIGAPSRLADYGIGEESLELIADKAMANGEFGKFKKLNRDDVLAILRASL
>NC_014650.1|WP_013400096.1|599853_600612_+|N-acetylmuramoyl-L-alanine-amidase
MVKIFIDPGHGGADPGAIGNGLQEKNVTLQIAVRVRDILLAEYDNVSIRMSRIGDQTVSLTERTAAANTWGADFYLSIHVNSGGGTGYEDYVYPGVGSPTTTYQKNIHEEIIKLVDFLDRGMKQANFFVLRETNMPAVLTENGFIDNANDAAKLKSSSFIENIARGHVNGIVRSFGLPKKSAGTLYKVQIGAFRVKTNADHLAAKAKAKGFNVYVIYKDGLYKVQIGAFANLENAKQLAEKAKAAGFEAIII
>NC_014650.1|WP_013400097.1|600766_602227_-|aldehyde-dehydrogenase-family-protein
MVNFKLLNKQYISGEWKDGTSNRQLIDFNPYNNEVITTFTCASLKDVDEAYRSAKEAQKKWQHTNPIEKRAVFENAVKYIEENKESIENIIIDELGGTKLKAAFEIDLVINIIKEAATYPFRMEGKILPSPVDGKENRLYRIPVGVVGVISPFNFPFFLSMKSVAPALGAGNGVVLKPHEHTPITGGTLIAKIFEEAGLPKGLLNVVITEIEEIGDGFIEHPIPKVISFTGSSKVGKHIGEVAGRHLKKVSLELGGNSALIVLDDADIDLAVSAAVFSRFTHQGQICMSANRIIVHEKVYDEFLTKYVRKVASLKCGDPRDPETIIGPLMNERQVQMIINLIETGIKEGATPILKGEVKGNIVEPVIFTDVTPDMTIAKEELFGPVVCIMKVENDQQAIEYANNSDFGLSGAIHTSNIERGAEMAKQIETGMIHINDGTINDEPIVAFGGEKNSGLGRLNGSWSLDAFTTVKWISIQHTPRKYPYS
>NC_014650.1|WP_003248384.1|602247_603120_-|methyl-accepting-chemotaxis-protein
MEKVEEKEKTNVEDIELLDAFLKVAPYLNQLVHEDITVGIYDTEKLIVNYPAKTFSLNVKPGDPLQEGDIITNAIKQNKLLSAIVPKELFGVGLIAKAMPIHDRNGRVVGGIGIGVNMEKAMQLSEISSNLSTVMEEITATIQSMADSITELSNEITTISEKAKEAAENVGKIEGISNLVKEIADQSNLLGLNAAIEAARAGEHGKGFSIVANEVRKMANTSKQHVEEINEKTNQMKNLIKQLNDFIQSVSEESSAQSAAIEELSATMQEINTNIQVLAEIAKQNIEIEK
>NC_014650.1|WP_013400098.1|604198_606022_+|APC-family-permease
MFSSLKRFLIGRPLKSTELGEQKLNKLKALAVLSSDALSSVAYGTEQILLVLATIGAIAFWYSLPIAIGVLILLMALILSYRQIIYSYPHGGGAYVVSKTNLGVNPGLIAGGSLLVDYILTVAVSVSAGTDAITSAFPTLHQYTVGIAIAMVVFITILNLRGINESASVLAYPVYLFVLALVILIIVGIFRIINGQVPSTLHTPVGTAVPGITLFLLLRAFASGCSALTGVEAISNAVPNFKEPAAKNAAKTLVMMGFILAFLFVGVTFLAYWYGIAPKAEETVVSQLASEVFGRSAMYYFIQGATALILILAANTGFSAFPLLAYNLASDKYMPRMYLIRGDRLGYSNGIITLGLASILVIVAFNGQTEQLIPLYAVGVFIPFTLSQTGMIVKWVREKPTGWVPKLLTNLLGAAITLTVLCIFFITKFTQVWAVLVFLPIIVFIFHQIHKHYDAVAEQLRVNPNEIPDKIEGNVVLVPVAGITKVVEQSLNYAQAIGDYVFAVYVAFDRESMLRMEGKWKKWRPDVRLVTLFSYYRDLITPISKLVDTIESKAEERNYTVTVLIPQFIPKKGWHNFLHNQSSVLLRLYLLYKKNVIVSTVPYRLHK
>NC_014650.1|WP_013400099.1|606528_607299_+|alanyl-tRNA-editing-protein
MTRELFLEDSYKKAHHAKVIEIKEDKIILDETIFYPTGGGQPHDTGMIKQGNETFKVNKVQRENGQIVHYVDNIEKLKQGPVEILIDWDRRYKFMRYHSLLHVLAGYLYNKFGALAIGNQIFEDRARIDFQFEEPLTNEQFNEIEDEINKLIQEDHQVSIRTVSREEAERIDGSIKTVINLLPPSIKNVRLVAIGDIDEQACGGTHVKETKEIGPFQISKIKSKGQNKKRLEVKSKLLCKFPFDRKHGPDDLTYGR
>NC_014650.1|WP_013400037.1|607433_608669_-|IS256-family-transposase
MAQYHITLNDELLHGLFTRDEGLAKLLEQVLNQILEAQVEEQLGARRYERTEERKGYRNGSYPRQLTTRVGRLTLRVPRTRDGEFSTELFQRYQRSEQALVLALMEMVVNGVSTRKITQITEELCGTSFSKSTVSSLCKGLDPIIQDWNYRSLHEHVYPFVLVDAIYTKVREDGRVRSRAVLIATGVNEEGYREILGLQIGNSESESSWSEFFGWLKDRGLRGVDLIISDQHGGLVQAIEKHFQGATWQRCQTHFIRNILDAAPKYMQDALLEEIRGILHAPNKQTARLLLEQVLAKWEEKAPKAMQILEEGFEDATAVLDYPDRYRRRLRTTNGVERLNEEIRRRERVIRIFPNRESVYRLVGAVLIEIDEKWMSGRKYLDMSEYWRWRKMKEQGVRSVNQEAPAIKRVG
>NC_014650.1|WP_013400100.1|609095_609545_-|NUDIX-domain-containing-protein
MRTRVRAAGVVVHNEHILLHKMDDFWVLPGGGVGFEATAEGLKREFKEELGIEIKIKNLLWVAENFFEYNNQKEQSIEFYYLIEFPENCALYNQNSFEGYEGKQTLKFKWHKIDNINNLTILPEFLAEYLKELRTSIPERIQHIINKTI
>NC_014650.1|WP_158306615.1|609815_609911_+|hypothetical-protein
MIDDNFRLTSGKIVLRRGGAEQLLKEIDQRL
>NC_014650.1|WP_013400101.1|610195_611395_-|site-specific-integrase
MASIQRRGKSSFLLVVEAGYDAKGKRLRRTKTIRIEDEALLKTTKKLRDYLNEELLKFKMEVEAGEYIAPEKMKLADFIKEWETKYAVKELSETTLNNYLSHIKNHILPALGHMRIDQIKPVHIVNFLDQIKRADGKKKPLATRTIENAYLTIRNILQRAVEWQIIKSNPASAVKKPKSKKEAVKEVQVYDEKEVEALFRAVQNEPFHWRIFTTLAIAAGLRRGELLALEWSNIDLEKGVIRINKAIVKGRKRSVEKSPKTKKSNRLVSLPKSVVAELKLYRRHWLKQKLQAGDLWKEEKEYLFCNIDGRHFYPTTPTTWWRRFTKRAGIRYIRLHDLRHTSATLLINQGVHAKIIAERLGHSDIRVTMDIYGHALQKADHEAANKLDHLFTNTSSQMK
>NC_014650.1|WP_013400102.1|611425_611575_-|Arm-DNA-binding-domain-containing-protein
MAYFRKVKAKNKKGYTWSFTIDIGTGKRKQITRRGFESFYFYENLIAEN

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Crispr_ID: NC_014650_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014650_6

1360181-1360275

Orphan

Consensus_repeat	Method
TGTTTCCATTATTGCCATTGTTG	CRISPRCasFinder

1 spacers

DinG

The CRISPR arrays of NC_014650_6

>merge|NC_014650|6|1360181-1360275|CRISPRCasFinder
CGCCACCGTTATTGCCATTGTTTCCATTATTGCCATTGTTGCCCGGATTATTGTCATTGCCGTTATTCCCGCTGTTTCCGTTATTGCCATTGTTG

>NC_014650|6|6|1360181-1360275|CRISPRCasFinder
CGCCACCGTTATTGCCATTGTTT	CCATTATTGCCATTGTTGCCCGGATTATTGTCATTGCCGTTATTCCCGC
TGTTTCCGTTATTGCCATTGTTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_014650.1\|WP_003249662.1\|1363645_1363894_+\|hypothetical-protein	unknown	unknown	unknown
NC_014650.1\|WP_003249669.1\|1365205_1365460_-\|sigma-G-dependent-sporulation-specific-acid-soluble-spore-protein-CsgA	unknown	unknown	gnl\|CDD\|340050
NC_014650.1\|WP_013400531.1\|1364828_1365167_+\|YppG-family-protein	unknown	unknown	gnl\|CDD\|372950
NC_014650.1\|WP_003249654.1\|1358667_1359318_+\|endonuclease-III	unknown	unknown	gnl\|CDD\|223255
NC_014650.1\|WP_013400527.1\|1357908_1358616_+\|DnaD-domain-containing-protein	unknown	unknown	gnl\|CDD\|226445
NC_014650.1\|WP_003249643.1\|1351055_1351439_+\|aspartate-1-decarboxylase	unknown	unknown	gnl\|CDD\|376751
NC_014650.1\|WP_003249641.1\|1350186_1351035_+\|pantoate--beta-alanine-ligase	unknown	unknown	gnl\|CDD\|234741
NC_014650.1\|WP_003249650.1\|1356548_1357841_+\|asparagine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235176
NC_014650.1\|WP_013400524.1\|1351515_1354281_+\|ATP-dependent-DNA-helicase-DinG	DinG	COG1199_DinG_CAS-IV-A	gnl\|CDD\|236148
NC_014650.1\|WP_013400528.1\|1359330_1359915_+\|hypothetical-protein	unknown	unknown	unknown
NC_014650.1\|WP_003249677.1\|1366809_1367484_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_014650.1\|WP_003249672.1\|1365901_1366375_-\|Hsp20/alpha-crystallin-family-protein	unknown	unknown	gnl\|CDD\|223149
NC_014650.1\|WP_013400532.1\|1365715_1365859_+\|hypothetical-protein	unknown	unknown	unknown
NC_014650.1\|WP_013400530.1\|1362782_1363382_-\|Holliday-junction-resolvase-RecU	unknown	unknown	gnl\|CDD\|235015
NC_014650.1\|WP_003249665.1\|1364463_1364661_-\|YppF-family-protein	unknown	unknown	gnl\|CDD\|290882
NC_014650.1\|WP_013400526.1\|1354738_1355221_+\|DUF5590-domain-containing-protein	unknown	unknown	gnl\|CDD\|227656
NC_014650.1\|WP_003249675.1\|1366467_1366698_+\|hypothetical-protein	unknown	unknown	unknown
NC_014650.1\|WP_013400525.1\|1354560_1354731_+\|YpmA-family-protein	unknown	unknown	gnl\|CDD\|379458
NC_014650.1\|WP_003249664.1\|1363959_1364328_+\|YppE-family-protein	unknown	unknown	gnl\|CDD\|378052
NC_014650.1\|WP_003249648.1\|1355242_1356433_+\|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl\|CDD\|235596

Protein	Function_ID	Function_description	E-value
NC_014650.1\|WP_003249672.1\|1365901_1366375_-\|Hsp20/alpha-crystallin-family-protein	gnl\|CDD\|223149	COG0071, IbpA, Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones].	1.22527e-13
NC_014650.1\|WP_003249669.1\|1365205_1365460_-\|sigma-G-dependent-sporulation-specific-acid-soluble-spore-protein-CsgA	gnl\|CDD\|340050	pfam17334, CsgA, Sigma-G-dependent sporulation-specific SASP protein. Curli are extracellular functional amyloids that are assembled by enteric bacteria during biofilm formation and host colonization. The csg (curli specific gene) operon encodes major structural and accessory proteins that are required for curli production. The csgBAC operon encodes the major and minor curli fiber components, CsgA and CsgB, respectively. CsgA is secreted to the extracellular milieu as an unfolded protein and forms amyloid polymers upon interacting with the CsgB nucleator. CsgA is comprised of five imperfect repeating units with highly conserved glutamine and asparagine residues that are important for amyloid formation. Each repeating unit is predicted to form a strand-loop-strand motif. In vitro, CsgC inhibits CsgA amyloid formation at substoichiometric concentrations and maintains CsgA in a non-beta-sheet rich conformation, making CsgC an efficient and selective amyloid inhibitor.	3.41693e-36
NC_014650.1\|WP_013400531.1\|1364828_1365167_+\|YppG-family-protein	gnl\|CDD\|372950	pfam14179, YppG, YppG-like protein. The YppG-like protein family includes the B. subtilis YppG protein, which is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 115 and 181 amino acids in length. There are two completely conserved residues (F and G) that may be functionally important.	2.84412e-22
NC_014650.1\|WP_003249654.1\|1358667_1359318_+\|endonuclease-III	gnl\|CDD\|223255	COG0177, Nth, Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair].	2.30437e-115
NC_014650.1\|WP_013400527.1\|1357908_1358616_+\|DnaD-domain-containing-protein	gnl\|CDD\|226445	COG3935, DnaD, Putative primosome component and related proteins [DNA replication, recombination, and repair].	6.89088e-67
NC_014650.1\|WP_003249643.1\|1351055_1351439_+\|aspartate-1-decarboxylase	gnl\|CDD\|376751	pfam02261, Asp_decarbox, Aspartate decarboxylase. Decarboxylation of aspartate is the major route of beta-alanine production in bacteria, and is catalyzed by the enzyme aspartate decarboxylase EC:4.1.1.11 which requires a pyruvoyl group for its activity. It is synthesized initially as a proenzyme which is then proteolytically cleaved to an alpha (C-terminal) and beta (N-terminal) subunit and a pyruvoyl group. This family contains both chains of aspartate decarboxylase.	1.15258e-73
NC_014650.1\|WP_003249641.1\|1350186_1351035_+\|pantoate--beta-alanine-ligase	gnl\|CDD\|234741	PRK00380, panC, pantoate--beta-alanine ligase; Reviewed.	4.99783e-159
NC_014650.1\|WP_003249650.1\|1356548_1357841_+\|asparagine--tRNA-ligase	gnl\|CDD\|235176	PRK03932, asnC, asparaginyl-tRNA synthetase; Validated.	0
NC_014650.1\|WP_013400524.1\|1351515_1354281_+\|ATP-dependent-DNA-helicase-DinG	gnl\|CDD\|236148	PRK08074, PRK08074, bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated.	0
NC_014650.1\|WP_003249677.1\|1366809_1367484_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	2.55097e-84
NC_014650.1\|WP_013400530.1\|1362782_1363382_-\|Holliday-junction-resolvase-RecU	gnl\|CDD\|235015	PRK02234, recU, Holliday junction-specific endonuclease; Reviewed.	1.14047e-120
NC_014650.1\|WP_003249665.1\|1364463_1364661_-\|YppF-family-protein	gnl\|CDD\|290882	pfam14178, YppF, YppF-like protein. The YppF-like protein family includes the B. subtilis YppF protein, which is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length. There is a conserved LLDF sequence motif.	7.37314e-28
NC_014650.1\|WP_013400526.1\|1354738_1355221_+\|DUF5590-domain-containing-protein	gnl\|CDD\|227656	COG5353, COG5353, Uncharacterized protein conserved in bacteria [Function unknown].	5.018e-36
NC_014650.1\|WP_013400525.1\|1354560_1354731_+\|YpmA-family-protein	gnl\|CDD\|379458	pfam14084, DUF4264, Protein of unknown function (DUF4264). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.	3.7716e-20
NC_014650.1\|WP_003249664.1\|1363959_1364328_+\|YppE-family-protein	gnl\|CDD\|378052	pfam08807, DUF1798, Bacterial domain of unknown function (DUF1798). This domain is found in many hypothetical proteins. The structure of one of the proteins in this family has been solved and it adopts an all alpha helical fold.	9.63978e-38
NC_014650.1\|WP_003249648.1\|1355242_1356433_+\|pyridoxal-phosphate-dependent-aminotransferase	gnl\|CDD\|235596	PRK05764, PRK05764, aspartate aminotransferase; Provisional.	0

>NC_014650.1|WP_013400528.1|1359330_1359915_+|hypothetical-protein
MLNSKQPMVIEEFSTIICIGREKGVPVMRVADEFAHPLFFREGEVIEIKDEQPFPHMMQHVYFYYDMIEREPFPWDDIGRSIPAVLQLWSEEKEQLESCFARRDRRSARAPMIRALSYLLSCLFWLNGKKVTNVRHWQEEIGALPLKPVNGLERLQFIFERCDVYHSFIQLCELFEETAKLAYKQMAINKRMSR
>NC_014650.1|WP_003249654.1|1358667_1359318_+|endonuclease-III
MLTKQQIRYCLDKMKEMFPDAHCELVHRNPFELLIAVVLSAQCTDALVNKVTKRLFEKYKTPEDYVAVPLEELQQDIRSIGLYRNKAKNIQKLCAMLIEKYGGQVPQDRDELMKLPGVGRKTANVVVSVAFGIPAIAVDTHVERVSKRLGFCRWEDSVLEVEKTLMKKIPKEEWSITHHRMIFFGRYHCKAQSPQCHVCPLLDLCREGKKRMKKKE
>NC_014650.1|WP_013400527.1|1357908_1358616_+|DnaD-domain-containing-protein
MDKKKLAEWLSQGSIAIPKLLLYHYKDLGLSEAEFVLLLHMHSFVEEGIVFPTPAELAEKMTVTPSECMEMLRKLLQKGFISIEENVDEQEIRSEKYSLQPLWEKLVHYLYAELLKEEKREQQEEEQSLYTVFEQEFGRPLSPFECETLAMWIDQDGHSPLLIKAALREAVLSGKLNFRYIDRILFEWKKNGIRTIEQAQNYGKRFRKYQQSSKPTQPAQSEYKQTIPFFNWLES
>NC_014650.1|WP_003249650.1|1356548_1357841_+|asparagine--tRNA-ligase
MKTTIAEVKNYVGQEVTIGAWLANKRSSGKIAFLQLRDGTGFIQGVVEKSKVTEEVFQIAKSISQETSLYVTGTVRVDERSPFGYELSVTNLEIIHEAVDYPITPKEHGVEFLMDHRHLWLRSRRQHAIMKIRNEVIRATYEFFNDRGFVKVDPPILTGSAPEGTTELFHTKYFDEDAYLSQSGQLYMEAAAMALGKVFSFGPTFRAEKSKTRRHLIEFWMIEPEMAFYEFEDNLTLQEEYVSHIVQSVLENCQLELKTLGRDTTKLELVKPPFPRITYDEAIQLLHDKGFDDIQWGDDFGAPHETAIAESFDKPVFITHYPAALKPFYMQPDPDRPDVVLCADLIAPEGYGEIIGGSERIHDYELLKKRIEEHHLPLDAYKWYLELRQYGSVPHSGFGLGLERTVAWICGVDHVRETIPFPRLLNRLYP
>NC_014650.1|WP_003249648.1|1355242_1356433_+|pyridoxal-phosphate-dependent-aminotransferase
MKLAKRVASLTPSTTLAITAKAKELKAAGYDVIGLGAGEPDFNTPQHIIDAAVKAMNEGHTKYTPSGGLPALKTEIIKKFEKDQRLHYEPSEIIVCVGAKHALYTLFQVILDEGDEVIIPTPYWVSYPEQVKLAGGVPVYVEGLEENEFKITPEQLKAAITERTKAVIINSPSNPTGMIYTEEELKALGEVCLEHDILIVSDEIYEKLVYGDAKHVSIAQLSPELKAQTIIINGLSKSHSMTGWRIGYAAGNKEIIKAMTDLASHSTSNPTSIAQYAAIAAYNGPQEPVEEMRKAFEERLNVIYEKLVQIPGFACVKPQGAFYLFPNAREAAKMAGYDTVDDLVKALLEEANVALVPGSGFGAPDNVRLSYATSLDVLEKAVERIKRFMENKLQRA
>NC_014650.1|WP_013400526.1|1354738_1355221_+|DUF5590-domain-containing-protein
MEMKKWLVLMLVFLCLGVWQAASVYQDALQPKQSLAEKALERAKEKIAFTRIDRTYTYYGDRTYTVFIGENKHGKKYIVWVPEKNGKIVVKRAESGITEKEAIAKLKAERHPKKLISAKLGMEKGVPLWELTYIDQHNRYSFYYLSFTDGTFLKRYSFQQ
>NC_014650.1|WP_013400525.1|1354560_1354731_+|YpmA-family-protein
MESKIEVLATVKIKHSDDLYKIVDCLNRTLKRNNLMFGLALDEKDKKQAIFTIYRT
>NC_014650.1|WP_013400524.1|1351515_1354281_+|ATP-dependent-DNA-helicase-DinG
MKDRFVIMDLETTGNVPKKGDRIIQLGMVVVENGQIIERFSSFFNPERDIPPFVQQLTNINEQMVADAPVFAEEAAKVVDMLQQSYFVAHNVSFDLQFLQEELHMAGFPPFSGPTIDTVELARIVFPDAESYKLADLAKLLCIAHDQPHHADSDAEVTAKLFIALLDRLRQLPLVTLQHLKRLSAYLKSDLYSLLDNMIMEKMTSLADEKSYIFYHGVALKKPAPVQKKDKGDHKRATFAEFFAGPRVLPLAHYERRDGQWEMMKLVYEALETSQHALVEAGTGIGKSLAYLIPSAFFAHERQKRVVISTHTLQLQQQLLERDIPFVKTIVPFPLRVAVLKGKRNYLSLDKFVAFLREHHHNYDVVLLKCQLLVWLTKTETGDMDELNVSSGARLFLPLLFMDEEDNGSKHNFFLRAKQRAEEADIVITNHAFLLHDVTASTPLLPDYEHIVIDEAHHLEDVASHYFGQQVDYVSIRLLLTRIGKINENGSLAKLMKLFERHHLSAEERFLRCERLVEELQFECDELFRMMRRYALARKPPESGRCRYRIEPKTESGRQWSAMKELLWRVRDHVAQLVDETKRLRAVFIQNEMETSRSNKSCSYFSDVFALNQIVDALFDLMESDDPMIVRWIEAEEKGAANATAIYSQPIQLDEFFAERLFMRKKSVVLTSATLTMNGSFSYIISRLGLSDFYPVCQTIPSPFSFKDQAILMVPSDFPSISSVSLEEYASAVADGVTQIAERIKGKMLVLFTSYELLRLTAAAMNMDERSGEHVLIAQGIQSGSAAKLTRVFQQFEQAILFGTSNFWEGVDLPGDELSVVVIVRLPFAPPDDPVISAKSEHIRAKGGNPFYELSLPEAVLRFKQGVGRLIRTKKDKGAVFVLDRRLTSASYGKYFLNSLPPLHVYEQSLDQLLQKLENWL
>NC_014650.1|WP_003249643.1|1351055_1351439_+|aspartate-1-decarboxylase
MFRTLMNAKIHRARVTEANLNYVGSITIDADILDAVGMVANEKVQVVNNNNGARFETYIIPGERGSGVFCLNGAAARLVQKGDIIIVISYAIVPEEKIAQHRPKIAIMDENNRIQQLIVEEPAHTVL
>NC_014650.1|WP_003249641.1|1350186_1351035_+|pantoate--beta-alanine-ligase
MIVTAKVQDMQTMMQQYRREGKTIGFVPTMGYLHEGHVALIRKAREENDIVALSVFVNPLQFGPNEDFARYPRDIERDQRIAKENGVDVFFCPSVEEMYPRPLSVQVVVKERVDVLCGRSRPGHFDGVATVLTKLFHIVMPTRAYFGMKDAQQVAVVDGLIRDFHFPIELVAVPTVREEDGLAKSSRNVYLSPEERKEAPALYQALQQAKQAIENGERHPEAVRALVINYIQAHTRAEIDYVEIYSYPELTSLEKLCGKVIIAVAVRFANARLIDNIVMDIK
>NC_014650.1|WP_013400530.1|1362782_1363382_-|Holliday-junction-resolvase-RecU
MAFKYPGGKTYDAKRMSEPVRPFQPNYGNRGMTLEEDLNATNEYYRERGIAVIHKKPTPVQIVRVDYPKRSAAVIKEAYFKQASTTDYNGVYRGKYIDFEAKETKNKTSFPLKNFHEHQIHHMKQVLQHGGICFVILRFATLNEVYLLDARHLIAFWERQQSGGRKSIPKREIERHGHYIALGYQPRIDYISVVEKVYF
>NC_014650.1|WP_003249662.1|1363645_1363894_+|hypothetical-protein
MSQRWVEKEEAEKQLYEILQLIQQVHEKMEKVVEDAIEECYEQNKMQLERVERQFDHVEQQLRDVAEESEPSLSLASKLFFV
>NC_014650.1|WP_003249664.1|1363959_1364328_+|YppE-family-protein
MEKQLKALTEKLLDYNKQLLYISQQAQKRQKEPDFFAEVKPFADQVKRVVDEWKQMALLWVKKARPRHIYEIQIETAGDNIEKAAVEAFYPSVPPRRIKQFCRSIEYTLLLVQERLEESMKQ
>NC_014650.1|WP_003249665.1|1364463_1364661_-|YppF-family-protein
MNMAELKNKFIAVKNYEPTDVNELLDFARQTYLRGEITIAQYRDLARELELAGAYKPDHKSEYVS
>NC_014650.1|WP_013400531.1|1364828_1365167_+|YppG-family-protein
MYRYPRPFSAPFSAYAPYHHTLPPYQYAPPFPSHWPAGQQTYTAMSPHSTPYPKPGPLLTPPAPGIQSLMAQFKTKDGTYDINKMMNTMGQMINTVNQVNGMLKGLIGTFKK
>NC_014650.1|WP_003249669.1|1365205_1365460_-|sigma-G-dependent-sporulation-specific-acid-soluble-spore-protein-CsgA
MEKTLAYLREILSNYTEYHDDTPRRIYQKLLSKPYKNEEEFVRDLSQKETAFLDRILPREIRYAMDERDLKRAYQLNEVYELLI
>NC_014650.1|WP_013400532.1|1365715_1365859_+|hypothetical-protein
MTNRNDNRERKNKYPDTREEMGKEWDIQKDPTPEINNKYGSKSHKNS
>NC_014650.1|WP_003249672.1|1365901_1366375_-|Hsp20/alpha-crystallin-family-protein
MSDHFQPPMKKEGNHHNPFQHLWEMVGQFFDERPLKNMMETLDEYFQQTFSHAYIPVDFRETKDEFAMIVHLPDDVKRHQLQLQFANDHLQLVIQNNEIIETADEQNHLYQQRRMRQQIVRTIPLPYRVSEKEVKASWQNGKLVIRLPQKRKYIDIE
>NC_014650.1|WP_003249675.1|1366467_1366698_+|hypothetical-protein
MFLTLIAYDGITKKIAPVLLRGTIARNRRQTKGGGAMHMFHWLAALFFSGTAVSLLSYQAFEIAQAFIDFLVDRHS
>NC_014650.1|WP_003249677.1|1366809_1367484_+|response-regulator-transcription-factor
MNHRVLIIEDEANLARFIELDLTHEGYEVRVSHDGREGLELALSEEWGLILLDVMLPSLNGMEVCRRIRAVKQTPIIMITARDSVFDRVMGLDNGADDYIVKPFAIEELLARIRALFRRVHAPAEERLLTFKDLTVDLDARTVKKGNQFIELTKREYDLLVTFLQNTNIVLTRDTLLDKVWGFDTEVETNVVDVYVRYLRHKLDETDKERYIQTVRGAGYVMRS

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Crispr_ID: NC_014650_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014650_7

1450222-1453456

Unclear

I-A

Consensus_repeat	Method
GTTTTATCTGAACGTAGTGGGATATAAAG	CRISPRCasFinder
GTTTTATCTGAACGTAGTGGGATATAAAG	CRT
GTTTTATCTGAACGTAGTGGGATATAAAG	PILER-CR

49 spacers

cas2,cas1,cas4,cas3,cas5,cas7,cas6,csm6

The CRISPR arrays of NC_014650_7

>merge|NC_014650|7|1450222-1453456|CRISPRCasFinder,CRT,PILER-CR
GTTTTATCTGAACGTAGTGGGATATAAAGATAACCAAGTCAGTCAGTCTGTACAGCGAATGAGCGTTTTATCTGAACGTAGTGGGATATAAAGGCGAACACAAGAGCACAACGTGTTTTACCGGACATCGTTTTATCTGAACGTAGTGGGATATAAAGATAACCAAGTCAGTCAGTCTGTACAGCGAATGAGCGTTTTATCTGAACGTAGTGGGATATAAAGATTTCCATTTGCGGCTTTCCCCTGTTTGTGCACCACCGTTTTATCTGAACGTAGTGGGATATAAAGTTGGCGATTTCTTGGCATCATCCTCCGGTGGTTTTTGTTTTATCTGAACGTAGTGGGATATAAAGTCCACGTGTAACAATGTGGAATTGCGATGCGGTATTCCGTTTTATCTGAACGTAGTGGGATATAAAGATGCTTGTAATGCTTGTTCGGCTTTTCGGAGTGCATGTTTTATCTGAACGTAGTGGGATATAAAGAAATCGGATCGTTTTCCGGCCGAACCCAAATGCCACGGTTTTATCTGAACGTAGTGGGATATAAAGCCGCATAACCGAGTCGGAACCGCATCGCATAACCGAGTTTTATCTGAACGTAGTGGGATATAAAGTGCACTCCTTTCTACGTATTTTGCGTATGAGTAAGGTTTTATCTGAACGTAGTGGGATATAAAGATGACATGGGAATTCATGTAGAGATGACTGGGCAAGGGTTTTATCTGAACGTAGTGGGATATAAAGGTCCTTGTGCGCTAAGTGTAGCTATTGACAAGATAATGTGTTTTATCTGAACGTAGTGGGATATAAAGAGCGTTAGCGCGGTAGGGTAGGACAGGCTGTCTTTGTTTTATCTGAACGTAGTGGGATATAAAGCATTCCCATACTCGTACAGCTCCACAACATGACCTGTTTTATCTGAACGTAGTGGGATATAAAGCCGCAACGTGTACATGCACCTTGAACAATGAAGTTGTTTTATCTGAACGTAGTGGGATATAAAGATTCGATCATTGCGTTTTCTTTGTTGAGTTTTTCGTTTTATCTGAACGTAGTGGGATATAAAGACTCAATAAGAATAAACATCATTCTTACAAACTCGTTTTATCTGAACGTAGTGGGATATAAAGATGCCACCCCTATTCCGAAAGGATAGGAAAAACAATGTTTTATCTGAACGTAGTGGGATATAAAGAGAAACTAGCAAGTAGAAAAATCGCAAGTGAAAAACAAGGTTTTATCTGAACGTAGTGGGATATAAAGAGGATGAACATGGGAACATCATCATGACGGGGAACGAGTTTTATCTGAACGTAGTGGGATATAAAGCAATGAAAAATCTTTCTGTGCTTGAGGAAGTATTCTGTTTTATCTGAACGTAGTGGGATATAAAGATGCTTTTTGCATAAAAACCTGCATAAAAGGGAGGTGAAGTTTTATCTGAACGTAGTGGGATATAAAGATCATCAAGATTGCCCACCGCGCATTTCAAGCGGTAGCGTTTTATCTGAACGTAGTGGGATATAAAGATCCATTCGGTTCGCAGTTCTTCTAGCGCTTCGCGTTTTATCTGAACGTAGTGGGATATAAAGTCATATCTTCCAAAACCGGAGTACAGTTGGCGTCATCGTTTTATCTGAACGTAGTGGGATATAAAGTGAACCACCGAATCCGCCGTTTCTCATCGTATTGGCGGGTTTTATCTGAACGTAGTGGGATATAAAGTACGGGGAAGTGATTGAGATGAAAGAAATCGAAAGGTTTTATCTGAACGTAGTGGGATATAAAGGGACTTCTCCCGGCGTTTGCAGCTCTCTACATTAAGTTTTATCTGAACGTAGTGGGATATAAAGTCGTAAACGTCTTTCAACCAACCAGTGATGATAACGGTTTTATCTGAACGTAGTGGGATATAAAGAAAGGAAGAGAAACATTCCGGTTGTTGTTGCAGAAGTTTTATCTGAACGTAGTGGGATATAAAGTTGGTTGCGAACATTCTTGGAACGGAGTGTTTGGGTTTTATCTGAACGTAGTGGGATATAAAGTTTCACATGTTGGACAGATTCGCTTTTGATCTTTGAGTGTTTTATCTGAACGTAGTGGGATATAAAGAGGTGAGAACGAAGTGGCGAAGATCATTCAACTATGTTTTATCTGAACGTAGTGGGATATAAAGATGCTTGACCTCATATTCAACGCACGCGCGAATCACGTTTTATCTGAACGTAGTGGGATATAAAGTTGAGCCTATATCATTAAATTTAATACAAAATATTTTTGAGTTTTATCTGAACGTAGTGGGATATAAAGCTCGTTCATACGCCGAATTATGCTTATACCCTATCGTCACGTTTTATCTGAACGTAGTGGGATATAAAGGATATTGCAACTTAGACATAGGGGAACGACAGTTCGTTTTATCTGAACGTAGTGGGATATAAAGAGCCTTCCTTACGTTTCCCTCTACGACCAGCAGGCTTGTTTTATCTGAACGTAGTGGGATATAAAGTTGAGCCTATATCATTAAATTTAACAAAAATATTTTTGAGTTTTATCTGAACGTAGTGGGATATAAAGGTTCTTTTTCAATGGTTTTCAGCGCTTCCTCAATGCGTTTTATCTGAACGTAGTGGGATATAAAGTCAATATCATTTACAGTTTCAATACGTGCAGCTGGTGTTTTATCTGAACGTAGTGGGATATAAAGGCTGATACAACCATTGACCAATGATGAACGCACACGTTTTATCTGAACGTAGTGGGATATAAAGGTGCTAGGCTGGCAAGCCGGAAGGCGCAAAGACATGTTTTATCTGAACGTAGTGGGATATAAAGTAAAAAGACATCAATTAGAATTTGATGGATATGATGGTTTTATCTGAACGTAGTGGGATATAAAGAAAGATAAAATGCAAATGAGTAATTTAAAGTTTGTTGAGTTTTATCTGAACGTAGTGGGATATAAAGGTATTACTAATTAGGCAAAAAGAAGACAGTACAATATGTTTTATCTGAACGTAGTGGGATATAAAGCCGCGACAAGCATGTTCAAATTCGTTGAGTAGATCGTGTTTTATCTGAACGTAGTGGGATATAAAGGCGATCGATACGCTCACGTTCAGATTTGGCCAATTGCGTTTTATCTGAACATAGTGGGATATAAAGCGACTACTAAAATAGCATTTTTCACCTCTTAATCTTTCAGTTTTATCTGAACGTAGTGGGATATCAAG

>NC_014650|7|7|1450222-1453456|CRISPRCasFinder
GTTTTATCTGAACGTAGTGGGATATAAAG	ATAACCAAGTCAGTCAGTCTGTACAGCGAATGAGC
GTTTTATCTGAACGTAGTGGGATATAAAG	GCGAACACAAGAGCACAACGTGTTTTACCGGACATC
GTTTTATCTGAACGTAGTGGGATATAAAG	ATAACCAAGTCAGTCAGTCTGTACAGCGAATGAGC
GTTTTATCTGAACGTAGTGGGATATAAAG	ATTTCCATTTGCGGCTTTCCCCTGTTTGTGCACCACC
GTTTTATCTGAACGTAGTGGGATATAAAG	TTGGCGATTTCTTGGCATCATCCTCCGGTGGTTTTT
GTTTTATCTGAACGTAGTGGGATATAAAG	TCCACGTGTAACAATGTGGAATTGCGATGCGGTATTCC
GTTTTATCTGAACGTAGTGGGATATAAAG	ATGCTTGTAATGCTTGTTCGGCTTTTCGGAGTGCAT
GTTTTATCTGAACGTAGTGGGATATAAAG	AAATCGGATCGTTTTCCGGCCGAACCCAAATGCCACG
GTTTTATCTGAACGTAGTGGGATATAAAG	CCGCATAACCGAGTCGGAACCGCATCGCATAACCGA
GTTTTATCTGAACGTAGTGGGATATAAAG	TGCACTCCTTTCTACGTATTTTGCGTATGAGTAAG
GTTTTATCTGAACGTAGTGGGATATAAAG	ATGACATGGGAATTCATGTAGAGATGACTGGGCAAGG
GTTTTATCTGAACGTAGTGGGATATAAAG	GTCCTTGTGCGCTAAGTGTAGCTATTGACAAGATAATGT
GTTTTATCTGAACGTAGTGGGATATAAAG	AGCGTTAGCGCGGTAGGGTAGGACAGGCTGTCTTT
GTTTTATCTGAACGTAGTGGGATATAAAG	CATTCCCATACTCGTACAGCTCCACAACATGACCT
GTTTTATCTGAACGTAGTGGGATATAAAG	CCGCAACGTGTACATGCACCTTGAACAATGAAGTT
GTTTTATCTGAACGTAGTGGGATATAAAG	ATTCGATCATTGCGTTTTCTTTGTTGAGTTTTTC
GTTTTATCTGAACGTAGTGGGATATAAAG	ACTCAATAAGAATAAACATCATTCTTACAAACTC
GTTTTATCTGAACGTAGTGGGATATAAAG	ATGCCACCCCTATTCCGAAAGGATAGGAAAAACAAT
GTTTTATCTGAACGTAGTGGGATATAAAG	AGAAACTAGCAAGTAGAAAAATCGCAAGTGAAAAACAAG
GTTTTATCTGAACGTAGTGGGATATAAAG	AGGATGAACATGGGAACATCATCATGACGGGGAACGA
GTTTTATCTGAACGTAGTGGGATATAAAG	CAATGAAAAATCTTTCTGTGCTTGAGGAAGTATTCT
GTTTTATCTGAACGTAGTGGGATATAAAG	ATGCTTTTTGCATAAAAACCTGCATAAAAGGGAGGTGAA
GTTTTATCTGAACGTAGTGGGATATAAAG	ATCATCAAGATTGCCCACCGCGCATTTCAAGCGGTAGC
GTTTTATCTGAACGTAGTGGGATATAAAG	ATCCATTCGGTTCGCAGTTCTTCTAGCGCTTCGC
GTTTTATCTGAACGTAGTGGGATATAAAG	TCATATCTTCCAAAACCGGAGTACAGTTGGCGTCATC
GTTTTATCTGAACGTAGTGGGATATAAAG	TGAACCACCGAATCCGCCGTTTCTCATCGTATTGGCGG
GTTTTATCTGAACGTAGTGGGATATAAAG	TACGGGGAAGTGATTGAGATGAAAGAAATCGAAAG
GTTTTATCTGAACGTAGTGGGATATAAAG	GGACTTCTCCCGGCGTTTGCAGCTCTCTACATTAA
GTTTTATCTGAACGTAGTGGGATATAAAG	TCGTAAACGTCTTTCAACCAACCAGTGATGATAACG
GTTTTATCTGAACGTAGTGGGATATAAAG	AAAGGAAGAGAAACATTCCGGTTGTTGTTGCAGAA
GTTTTATCTGAACGTAGTGGGATATAAAG	TTGGTTGCGAACATTCTTGGAACGGAGTGTTTGG
GTTTTATCTGAACGTAGTGGGATATAAAG	TTTCACATGTTGGACAGATTCGCTTTTGATCTTTGAGT
GTTTTATCTGAACGTAGTGGGATATAAAG	AGGTGAGAACGAAGTGGCGAAGATCATTCAACTAT
GTTTTATCTGAACGTAGTGGGATATAAAG	ATGCTTGACCTCATATTCAACGCACGCGCGAATCAC
GTTTTATCTGAACGTAGTGGGATATAAAG	TTGAGCCTATATCATTAAATTTAATACAAAATATTTTTGA
GTTTTATCTGAACGTAGTGGGATATAAAG	CTCGTTCATACGCCGAATTATGCTTATACCCTATCGTCAC
GTTTTATCTGAACGTAGTGGGATATAAAG	GATATTGCAACTTAGACATAGGGGAACGACAGTTC
GTTTTATCTGAACGTAGTGGGATATAAAG	AGCCTTCCTTACGTTTCCCTCTACGACCAGCAGGCTT
GTTTTATCTGAACGTAGTGGGATATAAAG	TTGAGCCTATATCATTAAATTTAACAAAAATATTTTTGA
GTTTTATCTGAACGTAGTGGGATATAAAG	GTTCTTTTTCAATGGTTTTCAGCGCTTCCTCAATGC
GTTTTATCTGAACGTAGTGGGATATAAAG	TCAATATCATTTACAGTTTCAATACGTGCAGCTGGT
GTTTTATCTGAACGTAGTGGGATATAAAG	GCTGATACAACCATTGACCAATGATGAACGCACAC
GTTTTATCTGAACGTAGTGGGATATAAAG	GTGCTAGGCTGGCAAGCCGGAAGGCGCAAAGACAT
GTTTTATCTGAACGTAGTGGGATATAAAG	TAAAAAGACATCAATTAGAATTTGATGGATATGATG
GTTTTATCTGAACGTAGTGGGATATAAAG	AAAGATAAAATGCAAATGAGTAATTTAAAGTTTGTTGA
GTTTTATCTGAACGTAGTGGGATATAAAG	GTATTACTAATTAGGCAAAAAGAAGACAGTACAATAT
GTTTTATCTGAACGTAGTGGGATATAAAG	CCGCGACAAGCATGTTCAAATTCGTTGAGTAGATCGT
GTTTTATCTGAACGTAGTGGGATATAAAG	GCGATCGATACGCTCACGTTCAGATTTGGCCAATTGC
GTTTTATCTGAACATAGTGGGATATAAAG	CGACTACTAAAATAGCATTTTTCACCTCTTAATCTTTCA
GTTTTATCTGAACGTAGTGGGATATCAAG

>NC_014650|7|3|1450222-1453456|CRT
GTTTTATCTGAACGTAGTGGGATATAAAG	ATAACCAAGTCAGTCAGTCTGTACAGCGAATGAGC
GTTTTATCTGAACGTAGTGGGATATAAAG	GCGAACACAAGAGCACAACGTGTTTTACCGGACATC
GTTTTATCTGAACGTAGTGGGATATAAAG	ATAACCAAGTCAGTCAGTCTGTACAGCGAATGAGC
GTTTTATCTGAACGTAGTGGGATATAAAG	ATTTCCATTTGCGGCTTTCCCCTGTTTGTGCACCACC
GTTTTATCTGAACGTAGTGGGATATAAAG	TTGGCGATTTCTTGGCATCATCCTCCGGTGGTTTTT
GTTTTATCTGAACGTAGTGGGATATAAAG	TCCACGTGTAACAATGTGGAATTGCGATGCGGTATTCC
GTTTTATCTGAACGTAGTGGGATATAAAG	ATGCTTGTAATGCTTGTTCGGCTTTTCGGAGTGCAT
GTTTTATCTGAACGTAGTGGGATATAAAG	AAATCGGATCGTTTTCCGGCCGAACCCAAATGCCACG
GTTTTATCTGAACGTAGTGGGATATAAAG	CCGCATAACCGAGTCGGAACCGCATCGCATAACCGA
GTTTTATCTGAACGTAGTGGGATATAAAG	TGCACTCCTTTCTACGTATTTTGCGTATGAGTAAG
GTTTTATCTGAACGTAGTGGGATATAAAG	ATGACATGGGAATTCATGTAGAGATGACTGGGCAAGG
GTTTTATCTGAACGTAGTGGGATATAAAG	GTCCTTGTGCGCTAAGTGTAGCTATTGACAAGATAATGT
GTTTTATCTGAACGTAGTGGGATATAAAG	AGCGTTAGCGCGGTAGGGTAGGACAGGCTGTCTTT
GTTTTATCTGAACGTAGTGGGATATAAAG	CATTCCCATACTCGTACAGCTCCACAACATGACCT
GTTTTATCTGAACGTAGTGGGATATAAAG	CCGCAACGTGTACATGCACCTTGAACAATGAAGTT
GTTTTATCTGAACGTAGTGGGATATAAAG	ATTCGATCATTGCGTTTTCTTTGTTGAGTTTTTC
GTTTTATCTGAACGTAGTGGGATATAAAG	ACTCAATAAGAATAAACATCATTCTTACAAACTC
GTTTTATCTGAACGTAGTGGGATATAAAG	ATGCCACCCCTATTCCGAAAGGATAGGAAAAACAAT
GTTTTATCTGAACGTAGTGGGATATAAAG	AGAAACTAGCAAGTAGAAAAATCGCAAGTGAAAAACAAG
GTTTTATCTGAACGTAGTGGGATATAAAG	AGGATGAACATGGGAACATCATCATGACGGGGAACGA
GTTTTATCTGAACGTAGTGGGATATAAAG	CAATGAAAAATCTTTCTGTGCTTGAGGAAGTATTCT
GTTTTATCTGAACGTAGTGGGATATAAAG	ATGCTTTTTGCATAAAAACCTGCATAAAAGGGAGGTGAA
GTTTTATCTGAACGTAGTGGGATATAAAG	ATCATCAAGATTGCCCACCGCGCATTTCAAGCGGTAGC
GTTTTATCTGAACGTAGTGGGATATAAAG	ATCCATTCGGTTCGCAGTTCTTCTAGCGCTTCGC
GTTTTATCTGAACGTAGTGGGATATAAAG	TCATATCTTCCAAAACCGGAGTACAGTTGGCGTCATC
GTTTTATCTGAACGTAGTGGGATATAAAG	TGAACCACCGAATCCGCCGTTTCTCATCGTATTGGCGG
GTTTTATCTGAACGTAGTGGGATATAAAG	TACGGGGAAGTGATTGAGATGAAAGAAATCGAAAG
GTTTTATCTGAACGTAGTGGGATATAAAG	GGACTTCTCCCGGCGTTTGCAGCTCTCTACATTAA
GTTTTATCTGAACGTAGTGGGATATAAAG	TCGTAAACGTCTTTCAACCAACCAGTGATGATAACG
GTTTTATCTGAACGTAGTGGGATATAAAG	AAAGGAAGAGAAACATTCCGGTTGTTGTTGCAGAA
GTTTTATCTGAACGTAGTGGGATATAAAG	TTGGTTGCGAACATTCTTGGAACGGAGTGTTTGG
GTTTTATCTGAACGTAGTGGGATATAAAG	TTTCACATGTTGGACAGATTCGCTTTTGATCTTTGAGT
GTTTTATCTGAACGTAGTGGGATATAAAG	AGGTGAGAACGAAGTGGCGAAGATCATTCAACTAT
GTTTTATCTGAACGTAGTGGGATATAAAG	ATGCTTGACCTCATATTCAACGCACGCGCGAATCAC
GTTTTATCTGAACGTAGTGGGATATAAAG	TTGAGCCTATATCATTAAATTTAATACAAAATATTTTTGA
GTTTTATCTGAACGTAGTGGGATATAAAG	CTCGTTCATACGCCGAATTATGCTTATACCCTATCGTCAC
GTTTTATCTGAACGTAGTGGGATATAAAG	GATATTGCAACTTAGACATAGGGGAACGACAGTTC
GTTTTATCTGAACGTAGTGGGATATAAAG	AGCCTTCCTTACGTTTCCCTCTACGACCAGCAGGCTT
GTTTTATCTGAACGTAGTGGGATATAAAG	TTGAGCCTATATCATTAAATTTAACAAAAATATTTTTGA
GTTTTATCTGAACGTAGTGGGATATAAAG	GTTCTTTTTCAATGGTTTTCAGCGCTTCCTCAATGC
GTTTTATCTGAACGTAGTGGGATATAAAG	TCAATATCATTTACAGTTTCAATACGTGCAGCTGGT
GTTTTATCTGAACGTAGTGGGATATAAAG	GCTGATACAACCATTGACCAATGATGAACGCACAC
GTTTTATCTGAACGTAGTGGGATATAAAG	GTGCTAGGCTGGCAAGCCGGAAGGCGCAAAGACAT
GTTTTATCTGAACGTAGTGGGATATAAAG	TAAAAAGACATCAATTAGAATTTGATGGATATGATG
GTTTTATCTGAACGTAGTGGGATATAAAG	AAAGATAAAATGCAAATGAGTAATTTAAAGTTTGTTGA
GTTTTATCTGAACGTAGTGGGATATAAAG	GTATTACTAATTAGGCAAAAAGAAGACAGTACAATAT
GTTTTATCTGAACGTAGTGGGATATAAAG	CCGCGACAAGCATGTTCAAATTCGTTGAGTAGATCGT
GTTTTATCTGAACGTAGTGGGATATAAAG	GCGATCGATACGCTCACGTTCAGATTTGGCCAATTGC
GTTTTATCTGAACATAGTGGGATATAAAG	CGACTACTAAAATAGCATTTTTCACCTCTTAATCTTTCA
GTTTTATCTGAACGTAGTGGGATATCAAG

>NC_014650|7|3|1450481-1453456|PILER-CR
GTTTTATCTGAACGTAGTGGGATATAAAG	TTGGCGATTTCTTGGCATCATCCTCCGGTGGTTTTT
GTTTTATCTGAACGTAGTGGGATATAAAG	TCCACGTGTAACAATGTGGAATTGCGATGCGGTATTCC
GTTTTATCTGAACGTAGTGGGATATAAAG	ATGCTTGTAATGCTTGTTCGGCTTTTCGGAGTGCAT
GTTTTATCTGAACGTAGTGGGATATAAAG	AAATCGGATCGTTTTCCGGCCGAACCCAAATGCCACG
GTTTTATCTGAACGTAGTGGGATATAAAG	CCGCATAACCGAGTCGGAACCGCATCGCATAACCGA
GTTTTATCTGAACGTAGTGGGATATAAAG	TGCACTCCTTTCTACGTATTTTGCGTATGAGTAAG
GTTTTATCTGAACGTAGTGGGATATAAAG	ATGACATGGGAATTCATGTAGAGATGACTGGGCAAGG
GTTTTATCTGAACGTAGTGGGATATAAAG	GTCCTTGTGCGCTAAGTGTAGCTATTGACAAGATAATGT
GTTTTATCTGAACGTAGTGGGATATAAAG	AGCGTTAGCGCGGTAGGGTAGGACAGGCTGTCTTT
GTTTTATCTGAACGTAGTGGGATATAAAG	CATTCCCATACTCGTACAGCTCCACAACATGACCT
GTTTTATCTGAACGTAGTGGGATATAAAG	CCGCAACGTGTACATGCACCTTGAACAATGAAGTT
GTTTTATCTGAACGTAGTGGGATATAAAG	ATTCGATCATTGCGTTTTCTTTGTTGAGTTTTTC
GTTTTATCTGAACGTAGTGGGATATAAAG	ACTCAATAAGAATAAACATCATTCTTACAAACTC
GTTTTATCTGAACGTAGTGGGATATAAAG	ATGCCACCCCTATTCCGAAAGGATAGGAAAAACAAT
GTTTTATCTGAACGTAGTGGGATATAAAG	AGAAACTAGCAAGTAGAAAAATCGCAAGTGAAAAACAAG
GTTTTATCTGAACGTAGTGGGATATAAAG	AGGATGAACATGGGAACATCATCATGACGGGGAACGA
GTTTTATCTGAACGTAGTGGGATATAAAG	CAATGAAAAATCTTTCTGTGCTTGAGGAAGTATTCT
GTTTTATCTGAACGTAGTGGGATATAAAG	ATGCTTTTTGCATAAAAACCTGCATAAAAGGGAGGTGAA
GTTTTATCTGAACGTAGTGGGATATAAAG	ATCATCAAGATTGCCCACCGCGCATTTCAAGCGGTAGC
GTTTTATCTGAACGTAGTGGGATATAAAG	ATCCATTCGGTTCGCAGTTCTTCTAGCGCTTCGC
GTTTTATCTGAACGTAGTGGGATATAAAG	TCATATCTTCCAAAACCGGAGTACAGTTGGCGTCATC
GTTTTATCTGAACGTAGTGGGATATAAAG	TGAACCACCGAATCCGCCGTTTCTCATCGTATTGGCGG
GTTTTATCTGAACGTAGTGGGATATAAAG	TACGGGGAAGTGATTGAGATGAAAGAAATCGAAAG
GTTTTATCTGAACGTAGTGGGATATAAAG	GGACTTCTCCCGGCGTTTGCAGCTCTCTACATTAA
GTTTTATCTGAACGTAGTGGGATATAAAG	TCGTAAACGTCTTTCAACCAACCAGTGATGATAACG
GTTTTATCTGAACGTAGTGGGATATAAAG	AAAGGAAGAGAAACATTCCGGTTGTTGTTGCAGAA
GTTTTATCTGAACGTAGTGGGATATAAAG	TTGGTTGCGAACATTCTTGGAACGGAGTGTTTGG
GTTTTATCTGAACGTAGTGGGATATAAAG	TTTCACATGTTGGACAGATTCGCTTTTGATCTTTGAGT
GTTTTATCTGAACGTAGTGGGATATAAAG	AGGTGAGAACGAAGTGGCGAAGATCATTCAACTAT
GTTTTATCTGAACGTAGTGGGATATAAAG	ATGCTTGACCTCATATTCAACGCACGCGCGAATCAC
GTTTTATCTGAACGTAGTGGGATATAAAG	TTGAGCCTATATCATTAAATTTAATACAAAATATTTTTGA
GTTTTATCTGAACGTAGTGGGATATAAAG	CTCGTTCATACGCCGAATTATGCTTATACCCTATCGTCAC
GTTTTATCTGAACGTAGTGGGATATAAAG	GATATTGCAACTTAGACATAGGGGAACGACAGTTC
GTTTTATCTGAACGTAGTGGGATATAAAG	AGCCTTCCTTACGTTTCCCTCTACGACCAGCAGGCTT
GTTTTATCTGAACGTAGTGGGATATAAAG	TTGAGCCTATATCATTAAATTTAACAAAAATATTTTTGA
GTTTTATCTGAACGTAGTGGGATATAAAG	GTTCTTTTTCAATGGTTTTCAGCGCTTCCTCAATGC
GTTTTATCTGAACGTAGTGGGATATAAAG	TCAATATCATTTACAGTTTCAATACGTGCAGCTGGT
GTTTTATCTGAACGTAGTGGGATATAAAG	GCTGATACAACCATTGACCAATGATGAACGCACAC
GTTTTATCTGAACGTAGTGGGATATAAAG	GTGCTAGGCTGGCAAGCCGGAAGGCGCAAAGACAT
GTTTTATCTGAACGTAGTGGGATATAAAG	TAAAAAGACATCAATTAGAATTTGATGGATATGATG
GTTTTATCTGAACGTAGTGGGATATAAAG	AAAGATAAAATGCAAATGAGTAATTTAAAGTTTGTTGA
GTTTTATCTGAACGTAGTGGGATATAAAG	GTATTACTAATTAGGCAAAAAGAAGACAGTACAATAT
GTTTTATCTGAACGTAGTGGGATATAAAG	CCGCGACAAGCATGTTCAAATTCGTTGAGTAGATCGT
GTTTTATCTGAACGTAGTGGGATATAAAG	GCGATCGATACGCTCACGTTCAGATTTGGCCAATTGC
GTTTTATCTGAACATAGTGGGATATAAAG	CGACTACTAAAATAGCATTTTTCACCTCTTAATCTTTCA
GTTTTATCTGAACGTAGTGGGATATCAAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_014650.1\|WP_013400575.1\|1442666_1444472_+\|CRISPR-associated-protein-Cst1	unknown	unknown	gnl\|CDD\|187796
NC_014650.1\|WP_003249794.1\|1455526_1456264_+\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173817
NC_014650.1\|WP_003249796.1\|1456458_1457610_+\|iron-containing-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|341481
NC_014650.1\|WP_013400576.1\|1444468_1445356_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|274215
NC_014650.1\|WP_003249800.1\|1459386_1459788_+\|hotdog-fold-thioesterase	unknown	unknown	gnl\|CDD\|131339
NC_014650.1\|WP_013400574.1\|1441941_1442670_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	gnl\|CDD\|187783
NC_014650.1\|WP_152333003.1\|1455294_1455555_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|183016
NC_014650.1\|WP_013400580.1\|1448764_1449748_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|274695
NC_014650.1\|WP_003249802.1\|1460380_1461706_+\|phenylacetate--CoA-ligase	unknown	unknown	gnl\|CDD\|341239
NC_014650.1\|WP_013400579.1\|1448266_1448764_+\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
NC_014650.1\|WP_013400577.1\|1445358_1446060_+\|type-I-B-CRISPR-associated-protein-Cas5	cas5	cd09658_cas5_CAS-I-B	gnl\|CDD\|187789
NC_014650.1\|WP_013400583.1\|1461800_1462769_+\|1,2-phenylacetyl-CoA-epoxidase-subunit-A	unknown	unknown	gnl\|CDD\|184320
NC_014650.1\|WP_003249809.1\|1463115_1463958_+\|phenylacetate-CoA-oxygenase-subunit-PaaC	unknown	unknown	gnl\|CDD\|368300
NC_014650.1\|WP_013400572.1\|1440304_1441246_+\|putative-CRISPR-associated-protein	csm6	cd09742_csm6_CAS-III-A:CAS-III-D	gnl\|CDD\|378231
NC_014650.1\|WP_003249807.1\|1462786_1463140_+\|1,2-phenylacetyl-CoA-epoxidase-subunit-B	unknown	unknown	gnl\|CDD\|225991
NC_014650.1\|WP_013400578.1\|1446072_1448253_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|273707
NC_014650.1\|WP_013400037.1\|1453571_1454807_+\|IS256-family-transposase	unknown	unknown	gnl\|CDD\|307151
NC_014650.1\|WP_013400581.1\|1449749_1450013_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NC_014650.1\|WP_013400573.1\|1441263_1441689_+\|hypothetical-protein	unknown	unknown	unknown
NC_014650.1\|WP_013400582.1\|1457633_1459103_+\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|143410

Protein	Function_ID	Function_description	E-value
NC_014650.1\|WP_013400575.1\|1442666_1444472_+\|CRISPR-associated-protein-Cst1	gnl\|CDD\|187796	cd09665, Cas8a1_I-A, CRISPR/Cas system-associated protein Cas8a1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Large proteins, some contain Zn-finger domain; signature gene for I-A subtype; also known as CXXC_CXXC family.	5.80751e-07
NC_014650.1\|WP_003249794.1\|1455526_1456264_+\|S8-family-serine-peptidase	gnl\|CDD\|173817	cd07492, Peptidases_S8_8, Peptidase S8 family domain, uncharacterized subfamily 8. This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	1.64699e-28
NC_014650.1\|WP_013400576.1\|1444468_1445356_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|274215	TIGR02585, conserved_protein, CRISPR-associated protein Cas7/Cst2/DevR, subtype I-B/TNEAP. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This clade is a member of the DevR family (TIGR01875) and includes the DevR protein of Myxococcus xanthus, a protein whose expression appears to be regulated through a number of means, including both location and autorepression; DevR mutants are incapable of fruiting body development.	2.71265e-57
NC_014650.1\|WP_003249800.1\|1459386_1459788_+\|hotdog-fold-thioesterase	gnl\|CDD\|131339	TIGR02286, Acyl-coenzyme_A_thioesterase_PaaI, phenylacetic acid degradation protein PaaD. This member of the domain family TIGR00369 (which is, in turn, a member of the pfam03061 thioesterase superfamily) is nearly always found adjacent to other genes of the phenylacetic acid degradation pathway. Its function is currently unknown, but a role as a thioesterase is not inconsistent with the proposed overall pathway. Sequences scoring between trusted and noise include those from archaea and other species not known to catabolize phenylacetic acid and which are not adjacent to other genes potentially involved with such a pathway.	1.62479e-34
NC_014650.1\|WP_013400574.1\|1441941_1442670_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|187783	cd09652, Cas6-I-III, CRISPR/Cas system-associated RAMP superfamily protein Cas6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas6 is an endoribonuclease that generates crRNAs, predicted subunit of Cascade complex; RAMP superfamily protein; Possesses double RRM/ferredoxin fold.	8.27637e-27
NC_014650.1\|WP_152333003.1\|1455294_1455555_+\|hypothetical-protein	gnl\|CDD\|183016	PRK11176, PRK11176, lipid A ABC transporter ATP-binding protein/permease MsbA.	2.72176e-06
NC_014650.1\|WP_013400580.1\|1448764_1449748_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274695	TIGR03641, cas1_HMARI, CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes Cas1 subgroup that includes Cas1 proteins of the related HMARI and TNEAP subtypes of CRISPR/Cas system.	1.33576e-164
NC_014650.1\|WP_003249802.1\|1460380_1461706_+\|phenylacetate--CoA-ligase	gnl\|CDD\|341239	cd05913, PaaK, Phenylacetate-CoA ligase (also known as PaaK). PaaK catalyzes the first step in the aromatic degradation pathway, by converting phenylacetic acid (PA) into phenylacetyl-CoA (PA-CoA). Phenylacetate-CoA ligase has been found in proteobacteria as well as gram positive prokaryotes. The enzyme is specifically induced after aerobic growth in a chemically defined medium containing PA or phenylalanine (Phe) as the sole carbon source. PaaKs are members of the adenylate-forming enzyme (AFE) family. However, sequence comparison reveals divergent features of PaaK with respect to the superfamily, including a novel N-terminal sequence.	0
NC_014650.1\|WP_013400579.1\|1448266_1448764_+\|CRISPR-associated-protein-Cas4	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	4.51534e-58
NC_014650.1\|WP_013400577.1\|1445358_1446060_+\|type-I-B-CRISPR-associated-protein-Cas5	gnl\|CDD\|187789	cd09658, Cas5_I-B, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex.	6.17686e-34
NC_014650.1\|WP_013400583.1\|1461800_1462769_+\|1,2-phenylacetyl-CoA-epoxidase-subunit-A	gnl\|CDD\|184320	PRK13778, paaA, phenylacetate-CoA oxygenase subunit PaaA; Provisional.	8.06033e-180
NC_014650.1\|WP_003249809.1\|1463115_1463958_+\|phenylacetate-CoA-oxygenase-subunit-PaaC	gnl\|CDD\|368300	pfam05138, PaaA_PaaC, Phenylacetic acid catabolic protein. This family includes proteins such as PaaA and PaaC that are part of a catabolic pathway of phenylacetic acid. These proteins may form part of a dioxygenase complex.	1.92989e-74
NC_014650.1\|WP_013400572.1\|1440304_1441246_+\|putative-CRISPR-associated-protein	gnl\|CDD\|378231	pfam09651, Cas_APE2256, CRISPR-associated protein (Cas_APE2256). This entry represents a conserved region of about 150 amino acids found in at least five archaeal and three bacterial species. These species all contain CRISPRs (Clustered Regularly Interspaced Short Palindromic Repeats). In six of eight species, the protein is encoded the vicinity of a CRISPR/Cas locus.	4.08039e-38
NC_014650.1\|WP_003249807.1\|1462786_1463140_+\|1,2-phenylacetyl-CoA-epoxidase-subunit-B	gnl\|CDD\|225991	COG3460, COG3460, Uncharacterized enzyme of phenylacetate metabolism [Secondary metabolites biosynthesis, transport, and catabolism].	4.19168e-40
NC_014650.1\|WP_013400578.1\|1446072_1448253_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|273707	TIGR01587, CRISPR-associated_endonuclease/helicase_Cas3, CRISPR-associated helicase Cas3. This model represents the highly conserved core region of an alignment of Cas3, a protein found in association with CRISPR repeat elements in a broad range of bacteria and archaea. Cas3 appears to be a helicase, with regions found by pfam00270 (DEAD/DEAH box helicase) and pfam00271 (Helicase conserved C-terminal domain). Some but not all members have an N-terminal HD domain region (pfam01966) that is not included within this model.	4.42925e-72
NC_014650.1\|WP_013400037.1\|1453571_1454807_+\|IS256-family-transposase	gnl\|CDD\|307151	pfam00872, Transposase_mut, Transposase, Mutator family.	2.13926e-156
NC_014650.1\|WP_013400581.1\|1449749_1450013_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	3.25124e-27
NC_014650.1\|WP_003249796.1\|1456458_1457610_+\|iron-containing-alcohol-dehydrogenase	gnl\|CDD\|341481	cd08551, Fe-ADH, iron-containing alcohol dehydrogenases (Fe-ADH)-like. This family contains large metal-containing alcohol dehydrogenases (ADH), known as iron-containing alcohol dehydrogenases. They contain a dehydroquinate synthase-like protein structural fold and mostly contain iron. They are distinct from other alcohol dehydrogenases which contains different protein domains. There are several distinct families of alcohol dehydrogenases: Zinc-containing long-chain alcohol dehydrogenases, insect-type, or short-chain alcohol dehydrogenases, iron-containing alcohol dehydrogenases, among others. The iron-containing family has a Rossmann fold-like topology that resembles the fold of the zinc-dependent alcohol dehydrogenases, but lacks sequence homology, and differs in strand arrangement. ADH catalyzes the reversible oxidation of alcohol to acetaldehyde with the simultaneous reduction of NAD(P)+ to NAD(P)H.	0
NC_014650.1\|WP_013400582.1\|1457633_1459103_+\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|143410	cd07091, ALDH_F1-2_Ald2-like, ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins. ALDH subfamily which includes the NAD+-dependent retinal dehydrogenase 1 (RALDH 1, ALDH1, EC=1.2.1.36), also known as aldehyde dehydrogenase family 1 member A1 (ALDH1A1), in humans, a homotetrameric, cytosolic enzyme that catalyzes the oxidation of retinaldehyde to retinoic acid. Human ALDH1B1 and ALDH2 are also in this cluster; both are mitochrondrial homotetramers which play important roles in acetaldehyde oxidation; ALDH1B1 in response to UV light exposure and ALDH2 during ethanol metabolism. 10-formyltetrahydrofolate dehydrogenase (FTHFDH, EC=1.5.1.6), also known as aldehyde dehydrogenase family 1 member L1 (ALDH1L1), in humans, a multi-domain homotetramer with an N-terminal formyl transferase domain and a C-terminal ALDH domain. FTHFDH catalyzes an NADP+-dependent dehydrogenase reaction resulting in the conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO2. Also included in this subfamily is the Arabidosis aldehyde dehydrogenase family 2 members B4 and B7 (EC=1.2.1.3), which are mitochondrial, homotetramers that oxidize acetaldehyde and glycolaldehyde, as well as, the Arabidosis cytosolic, homotetramer ALDH2C4 (EC=1.2.1.3), an enzyme involved in the oxidation of sinapalehyde and coniferaldehyde. Also included is the AldA aldehyde dehydrogenase of Aspergillus nidulans (locus AN0554), the aldehyde dehydrogenase 2 (YMR170c, ALD5, EC=1.2.1.5) of Saccharomyces cerevisiae, and other similar sequences.	0

>NC_014650.1|WP_013400581.1|1449749_1450013_+|CRISPR-associated-endonuclease-Cas2
MYVIITYDVGEKRVNKVCKKLKEYLTWTQNSVFEGEISKSLLMKCMHELEFIINKQEDSIYLYQVSNPKNIKKQILGQERNFDDLFI
>NC_014650.1|WP_013400580.1|1448764_1449748_+|type-I-B-CRISPR-associated-endonuclease-Cas1
MLRDHYIFSNGRLKRKDNTIYFFDENETKKSLPVHQVDNLYVFGEVDLNSSLLNLLSQHSVHLHIFNYYGFYAGTFCPRNKKVSGFTVVQQSAHYLDATKRLYLAKMFLQSAVHHMLRNIRRYKEKTEEYVRQIELEAKKLDTATDIQELMGIEGRIRQYYYQSFNEILKQDFIFEKRTKQPPQDPLNALISFGNTLCYTTVLSEIYKTPLDPTVSFLHEPSTKRFSLSLDLAEIFKPLIVDSVIIACINNRVITPKHFDYLEGMVFLNEEGKKKFIREWETKLATSIQHRQLKRKVSYRYFMRLECYKLIKHFIGDERYKPLKAWW
>NC_014650.1|WP_013400579.1|1448266_1448764_+|CRISPR-associated-protein-Cas4
MVSGVQMHYYKVCKRKLWLFSRGIAFEEEHDRVVEGKILHERAYPRLDEREILVDNKFKLDALDGEYIREIKISSKMADADRFQMLYYLYELKKRGIIKKGLISYTKERKTEEVVLTENDEKKIEKAIGEIHQVLQLPSPPPLKKLTYCPKCAYYEFCYVLEGDE
>NC_014650.1|WP_013400578.1|1446072_1448253_+|CRISPR-associated-helicase/endonuclease-Cas3
MTFYAKSETKETIREHTDRLLDNLQLLKDSYGRKFVRMDERMWELLRLAAEYHDVGKANTVFQNKIRRAIRDEMLETDCDADVPHNYLSVGLIPFSQLDLTKEESRLLIHAVGYHHERDKPPDKEMIRHILEADMKKQRNAISEHMQLPLAEKLSFRFVDRLLKRYTIHDGEQFWNYVLLKGLLHRIDHAASAHLPVEIDIDRSVGASVRTYMKKQGFRKNALQQFTEANQDKNVVVIAQTGMGKTEAALLWIGDDKAFFTLPLRVSINAIYERIRDKMGYDAVGLLHSTSVHYLAEKGEENWEAMKQQSQQLSTKLLMTTIDQILKFPFYYRGFEKELATMANAKIVIDEIQAYDPKIAAMLIKALEMIHNVGGKFMIMTATLPTLYLDELKKRNIIDEEHSAFGEFIDTSKHRHRIQLHAKEITEGLEDIVRKAQTSQVLVIVNTVRRAIELYQNLLERELHIPVYLLHSQFTQEDRQLLERKIKEFNDEKINGIWITTQLVEASIDIDFDYLFTEMSTLDSLFQRLGRCYRKRILNEERCNVHIFTKNISGVPRVYNEHLINESIKLLQPYDGHILDERTKVEMVKQLYERKRLIGTEFLQDFEDALYMFDNLDPYGMNKKEAQRKLRDIQNIQVIPRRIYDGIIDLLEMYAACRDVKKRLHLRMEIEKKTVSVSRFIAEKYVSERLPKPFEHIYIIDVEYDFQRETWKGKGILLDTPMSTFY
>NC_014650.1|WP_013400577.1|1445358_1446060_+|type-I-B-CRISPR-associated-protein-Cas5
MKALRMKLFQETACYKKPFASKVAETYPLPPYSTVKGMLHALIRADAFIPMRLSIQGQYEAKLLDYQRYYFFKKKEMKSFPLILDGVRGLDFSYDKDEMTTMPMYTHLLYRVDLLIHVEAEEEVLENIIQAVETGSNHYSLGRWEDLVRIDEYKLVHVQELDEEKELRYNAYIPKHLLEEEIRHIPYEVNWKYEIINGIRQWETIHVGYVLKGTTAPEGTMVDEDGELVFYHA
>NC_014650.1|WP_013400576.1|1444468_1445356_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MTKSLTMTIVFQAGSLNYGEGIANISELKKFHRGNGEVYTYASRQSLRYDIVRLGNELFDWNLNTVDKASGVVQFKKDVTIKDSVEMDLFGYLKTDKNSQKRAAVVRLSHAISLEPYKSDLEFLNNMGLASRIGMDANIANIEQHQSFYTYTLTMDLNRVGVDGDVELSNAEKATRVQQLLDIVKILNRNIRGRRENLAPLFIIGGVYDVANPFFLGKIFLSSSSQGWEIQSQPIVETMKQTFAGQTVGEQTRIGFLHGIFANEGEFADLFADKVGSIEQFFQSISKQIQTYYGV
>NC_014650.1|WP_013400575.1|1442666_1444472_+|CRISPR-associated-protein-Cst1
MKVQLHMGEWMITMGLVGLYRVFEYGLRNEIIDQQYRQSISVRPWGLELDIDVLPQLPKAYFLYLIDEYSVAKRDSEKLRLYMKQAEKEGQFPQALSAIKKTMTDTGKKVLKYFSHQPLANALAALKQVKKPENFELLATCIHTFETALHEPKINEKLTLNYFKAAILKAFFGQVSFLNVSKNSLDLQGHIQEFQKDYIVPAQHDLQLEHVLTDAKSSEEIIAFLDKYKDYQPFKSLKRAWKNKTLENIRSHADNTITKCLLLQEHLAFYNFEEMVFSPIGVAKNNAFNFNWNLEDYQPKPISSLAKLVLFFAPAGAAIYLKKEGFNDQGEYRTYAGFVQSDAAFPEILQKNNHFKQLKQQREPFDSIVSKLVQGVTKEAEYVADHLLFIEFSSDYDSKKTHLHYYHLPMYLAKYFQIYKGKLDYIRPYEYREHFVQHVLRGADPAIVVYPYLRYCIEKGYSHIGPYIAVRERNRILQLKKGVKDMSSTDKRVYAVFRSGQEIRKALEQATASKAAEQYSASSNKKVNAIAYRLLNAAKAGNQKSFMDTLFRLHMSAEKPISPIFLNALHERDLDFATVANAFIAGLLSSGLQEEQEDVVS
>NC_014650.1|WP_013400574.1|1441941_1442670_+|CRISPR-associated-endoribonuclease-Cas6
MRISCSFNTDKIPIHYRMAMVSIIKEALRTSDEAYYHRLYQKGQHMKPFSFSTYLKNFRMFSHEIKLDGITLTVSSPDHEFLLHLYNGLQKNRAFSYKDYHFVKKKIAVVNEKQVTSPSVVFRTLSPILIEDEKGNPVAPDDESYAEHVNYIANMILSQYRGTGLYVSLSIKPVYFKKVVVKESNHEFAAACGDDEYLYFTAYHGLFAVTGHPEDLQLLYQLGLSKRRNQGFGQLEIEEVRG
>NC_014650.1|WP_013400573.1|1441263_1441689_+|hypothetical-protein
MASELCTTAICLKNGWDPTGKKKEDEEKSKRQIVDEILNIAIKINEKSASLDKHLDNEHLPLLKTLLSHSTLLSVLKNIRYYRNDINHAGWKPDLLLSGKFREKFDEWFPLFRSSLLAFWTDGNLDEKENDHKGSHISMEG
>NC_014650.1|WP_013400572.1|1440304_1441246_+|putative-CRISPR-associated-protein
MPHPYIIRCHDQHTSFHPGQTLVFDLLLLGPSNTDFAMYLFRVFEDFHLYPFGVDRAFFYLQAVYQLFDQTKEGVLKNNYVVKPEMTYFHAEEKHYGKMLIQFITPCRMVRKEKVLRQLSVEEILQRIYELEDHTKLCAEMSSITSLLHEGIVNDPQNLYLLASDTEEGEKISRILKAYFQPMFRHVHTFSIENLNGEKPELFRDEGLRNLVKVIVQIVRVVPGREEESVINATGGYKAQISFAGLIGQVLKIPVYYQFEGFASVISLPEMPVFFDYKIWLKRFQLFRDLYQLGVISTKLLPERTDLSALKGA
>NC_014650.1|WP_013400037.1|1453571_1454807_+|IS256-family-transposase
MAQYHITLNDELLHGLFTRDEGLAKLLEQVLNQILEAQVEEQLGARRYERTEERKGYRNGSYPRQLTTRVGRLTLRVPRTRDGEFSTELFQRYQRSEQALVLALMEMVVNGVSTRKITQITEELCGTSFSKSTVSSLCKGLDPIIQDWNYRSLHEHVYPFVLVDAIYTKVREDGRVRSRAVLIATGVNEEGYREILGLQIGNSESESSWSEFFGWLKDRGLRGVDLIISDQHGGLVQAIEKHFQGATWQRCQTHFIRNILDAAPKYMQDALLEEIRGILHAPNKQTARLLLEQVLAKWEEKAPKAMQILEEGFEDATAVLDYPDRYRRRLRTTNGVERLNEEIRRRERVIRIFPNRESVYRLVGAVLIEIDEKWMSGRKYLDMSEYWRWRKMKEQGVRSVNQEAPAIKRVG
>NC_014650.1|WP_152333003.1|1455294_1455555_+|hypothetical-protein
MKRQRSSLSTYSKWRIEWRKARPNRTLIVISHRIASLDWLKRYLVIEHGKIVETTSYEEMINKIEKAERAGEKGEERSGSIYQPSL
>NC_014650.1|WP_003249794.1|1455526_1456264_+|S8-family-serine-peptidase
MEASISQACNSQRNEVKIAVIDSGVNPYHSHINGIDGGIALRVNREGGIEYHDDLRDRLGHGTAVTAVLKYLLSDVRVFAVKIFDEKLATYPSVLAEAIYWCINEKMNIVNLSLGIARDDKKVREACQAAYEAGIVMVSAYDEGNQLYWPAKYETVLGVCAGEVPRHEWRFVTKKFFRACGYPRELPSNLQLYNIHGHSFAAAHFSATVARLLQEHYDWQSGDVFMYFENLYRNRVLYYMDASSR
>NC_014650.1|WP_003249796.1|1456458_1457610_+|iron-containing-alcohol-dehydrogenase
MQFQFGIPSQAIFGEGSIQKLPEVLTQFDAKKILLVYDSGVKAAGIIDHVHNLLSNVEADVVAFDKVLPNPPDTIVEEGAELAKKEQVDMIIAVGGGSTIDCAKAINILLTNPGPIHQYDGLNLVKNPTKPLIAVPTTAGTGSEVTAFTVITDTTGLKKMVIGGQHCGATIALLDPELTIGLPPSVTAATGMDALTHAIEAYVSKAASIPSDINALKAVELIFNNLEEAYQNGTNKTARTNMLLGSMLAGYAFNSAVLGLVHAIAHPLSVHCGLAHGVANACCLPYVMEFNAECENVAEKYKNIAIAMGLDVQGLSIKESAQCAIDAVKELSESIDIPALRELGVRKEQFDRLAEDTLKEIAILFNPREATKEDVLRILETAY
>NC_014650.1|WP_013400582.1|1457633_1459103_+|aldehyde-dehydrogenase-family-protein
MKKYQLFIDGKWVDSVSGKTFTSINPATKEVNGIIAEGDAADIDLAVKAARKAFESGPWASMSPSERGRLLYRAAQKLWENVDYLAEVESNDNGLTINETKLIAIPAAIDVLEFYAGIANKIQGDTLASPANRFNYTLREPVGVVGAIVPWNFPIMLTMWKLAPALAAGNTIVIKPAEQTPISVLELARLLQEAGIPDGVINVVNGYGPTAGAALASHPDVDKIAFTGSTATGRLIMQAASKHLKPISLELGGKSPNIVFDDADMDAAISGSLFGIYFAQGQVCAAGSRMFVQETIYDRFVEEFARKAESIRVGHPLDPATQMGPQVSEEQLNIIERYVEIGKQEGATLVTGGKRKEECGNGFYYTPTVFADVDNNMTIAKEEIFGPVVSIIRFKDEEDVLKKANESIYGLASGVWTTNLARAHRMARGLKAGTVYVNTFSMLDSAAPFGGMKQSGFGRELGIEAMNMYTQTKHVWVDLSQEKFNWYGL
>NC_014650.1|WP_003249800.1|1459386_1459788_+|hotdog-fold-thioesterase
MGDFMKKMKEDPFANYLGITIEDVEEGYAKVSMEIKGNLLNFHGSANGGAIFSLADVAFACASNSHHQAAVGIAMTIYYMQASGMGDRLVAIAREETKPHRLGVYRIEVLNDKGELIALAEGMAYRKRDKLVP
>NC_014650.1|WP_003249802.1|1460380_1461706_+|phenylacetate--CoA-ligase
MILHRIETASRAEMETLQLERLQQTVKRVYEHVPFYRQKLDEHGVKPEHIRTLNDVKKLPFTTKKDLREHYPFGLLAVSIQDCVRIHASSGTSGKPTVVAYTKNDINHWADVVARAIAIAGGKPGNIVHNAYGYGLFTGGLGLHYGSERLGAVTVPVSGGNTDRQIMIIEDFKPDVICGTPSYVLNIAERMKELGKDPRKTSLKYGIFGAEPWSEEMRRTLEREFGIKACDIYGLSEVIGPGVAMECHEAQNGLHVAEDHFFVEVIHPDTLEPVGEGEEGELVFTSLTKEAFPVIRYRTGDIASITKEPCACGRTTTRMSRIKGRVDDMLIIRGVNVFPSEIEHYLLTVPELAPHYQVHILRKGMLDVVELQVEISERFYQEIRSNLHDERVRDLVKRIQHLLKNHCLVSINVNIHPPKSIPRSEGKAIRIVDYRKEKALL
>NC_014650.1|WP_013400583.1|1461800_1462769_+|1,2-phenylacetyl-CoA-epoxidase-subunit-A
MPVVTSLRRISEEEKYERFMKRIEAGEKIEADDWMPEDYRMTLIKLIAMHGISEIMGALPEKEWVPKAPSLRRKLGIMAKVQDEMGHGQLLLRVAEDLMAPLGKTREEIMQDLFKGDLKFHNVFHMPAPTWADAGLIGWLVDGAAIITQTNMLDASYGPYARALKRICAEEVFHAQHGESIILALAEGTKEQKEMLQDALNRWWEALLMFFGPDSVATTGTSKQDITIKYRIRTKTNEQLRQDFFTKYVPRILSIGLKLPDETMHFDEAKGKWVYKQPDWNKFKEIIRNNGPKSKERLRLRELSYHNNAWVREALSGQSAAV
>NC_014650.1|WP_003249807.1|1462786_1463140_+|1,2-phenylacetyl-CoA-epoxidase-subunit-B
MSDSGKGFYQVFEVFSRKNDTAPLQHQFSLLAPNHEIALVMAQENFMRRETVSDIWVVKRSDIRMMTEEEKESLKRLDNKDYRTTKGYGYLKKKWRQYEQQMLDEKEILSWKGEIQR
>NC_014650.1|WP_003249809.1|1463115_1463958_+|phenylacetate-CoA-oxygenase-subunit-PaaC
MEGRDPAMKITKPEELQQHPEYKEALVELLFQLADDDFILSYRGSEWLGLAPHIEEDIAFSSINQDTMGHAAMYYQLLEDIGIGKADVLAHQRPSSERRNAILLEEVNGPGHYLREPRYDWAFAVVRHYFYTQAKKVRVDSLKHSSYEPLAQVAVKINMELYYHLMHWRTWFIQLTNAQGEARERMKKAVVKVFEDFGGVLTLGMKGDRMVEFGLIENEEILKHRWIQAMQPVFAEVNLDLPSEFGMKRGNGRNGEHTADLDEAIMTLSEVYRLDPLATW

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Crispr_ID: NC_014650_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014650_8

1720776-1720869

Orphan

Consensus_repeat	Method
GTGCGGCTTGTACAAATTGGAGAGAAGG	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NC_014650_8

>merge|NC_014650|8|1720776-1720869|CRISPRCasFinder
GTGCGGCTTGTACAAATTGGAGAGAAGGTTCGCGTTTGTGACGATTTTGCCTGGCTTCGTGCGACCGTGCGGCTTGTACAAATTGGAGAGAAGG

>NC_014650|8|8|1720776-1720869|CRISPRCasFinder
GTGCGGCTTGTACAAATTGGAGAGAAGG	TTCGCGTTTGTGACGATTTTGCCTGGCTTCGTGCGACC
GTGCGGCTTGTACAAATTGGAGAGAAGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_014650.1\|WP_173662713.1\|1713255_1713528_+\|autorepressor-SdpR-family-transcription-factor	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NC_014650.1\|WP_013400744.1\|1718617_1718968_+\|hypothetical-protein	unknown	unknown	unknown
NC_014650.1\|WP_173662712.1\|1716629_1716890_+\|DUF3784-domain-containing-protein	unknown	unknown	gnl\|CDD\|378903
NC_014650.1\|WP_003250202.1\|1715261_1716011_+\|oxygen-insensitive-NADPH-nitroreductase	unknown	unknown	gnl\|CDD\|380322
NC_014650.1\|WP_013400749.1\|1725777_1726383_-\|polysaccharide-deacetylase-family-protein	unknown	unknown	gnl\|CDD\|200580
NC_014650.1\|WP_013400752.1\|1728607_1728994_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319937
NC_014650.1\|WP_013399927.1\|1723491_1724232_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|181681
NC_014650.1\|WP_013400756.1\|1733374_1733671_+\|YwqI/YxiC-family-protein	unknown	unknown	gnl\|CDD\|375099
NC_014650.1\|WP_013400745.1\|1719255_1719888_-\|TetR/AcrR-family-transcriptional-regulator-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|172294
NC_014650.1\|WP_013400739.1\|1714384_1714822_+\|SRPBCC-domain-containing-protein	unknown	unknown	gnl\|CDD\|176856
NC_014650.1\|WP_003250225.1\|1732308_1732512_+\|copper-chaperone-CopZ	unknown	unknown	gnl\|CDD\|225328
NC_014650.1\|WP_013399926.1\|1721990_1723520_+\|IS21-family-transposase	unknown	unknown	gnl\|CDD\|226950
NC_014650.1\|WP_013400754.1\|1729895_1732289_+\|copper-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319783
NC_014650.1\|WP_013400743.1\|1717177_1718527_+\|putative-sulfate-exporter-family-transporter	unknown	unknown	gnl\|CDD\|225411
NC_014650.1\|WP_013400738.1\|1713524_1714163_+\|SdpI-family-protein	unknown	unknown	gnl\|CDD\|227945
NC_014650.1\|WP_041269467.1\|1729127_1729385_-\|excalibur-calcium-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|377566
NC_014650.1\|WP_013400755.1\|1732955_1733300_+\|DUF5082-domain-containing-protein	unknown	unknown	unknown
NC_014650.1\|WP_003250200.1\|1714830_1715184_+\|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NC_014650.1\|WP_003250220.1\|1729570_1729882_+\|metal-sensing-transcriptional-repressor	unknown	unknown	gnl\|CDD\|197392
NC_014650.1\|WP_041269347.1\|1719032_1719248_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_014650.1\|WP_173662713.1\|1713255_1713528_+\|autorepressor-SdpR-family-transcription-factor	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	4.44248e-20
NC_014650.1\|WP_013400739.1\|1714384_1714822_+\|SRPBCC-domain-containing-protein	gnl\|CDD\|176856	cd07814, SRPBCC_CalC_Aha1-like, Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins. This family includes the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of Micromonospora echinospora CalC, human Aha1, and related proteins. Proteins in this group belong to the SRPBCC domain superfamily of proteins, which bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. MeCalC confers resistance to the enediyne, calicheamicin gamma 1 (CLM), by a self sacrificing mechanism which results in inactivation of both CalC and the highly reactive diradical enediyne species. MeCalC can also inactivate two other enediynes, shishijimicin and namenamicin. A crucial Gly of the MeCalC CLM resistance mechanism is not conserved in this subgroup. This family also includes the C-terminal, Bet v1-like domain of Aha1, one of several co-chaperones, which regulate the dimeric chaperone Hsp90. Aha1 promotes dimerization of the N-terminal domains of Hsp90, and stimulates its low intrinsic ATPase activity, and may regulate the dwell time of Hsp90 with client proteins. Aha1 can act as either a positive or negative regulator of chaperone-dependent activation, depending on the client protein, but the mechanisms by which these opposing functions are achieved are unclear. Aha1 is upregulated in a number of tumor lines co-incident with the activation of several signaling kinases.	4.10902e-26
NC_014650.1\|WP_173662712.1\|1716629_1716890_+\|DUF3784-domain-containing-protein	gnl\|CDD\|378903	pfam12650, DUF3784, Domain of unknown function (DUF3784). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 96 and 110 amino acids in length.	0.00271336
NC_014650.1\|WP_003250202.1\|1715261_1716011_+\|oxygen-insensitive-NADPH-nitroreductase	gnl\|CDD\|380322	cd02146, NfsA-like, nitroreductase similar to Escherichia coli NfsA. This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as an electron donor. Oxygen-insensitive nitroreductase, such as NfsA protein in Escherichia coli, catalyzes reduction of nitrocompounds using NADPH as electron donor.	1.12353e-114
NC_014650.1\|WP_013400749.1\|1725777_1726383_-\|polysaccharide-deacetylase-family-protein	gnl\|CDD\|200580	cd10956, CE4_BH1302_like, Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs. This family is represented by a putative polysaccharide deacetylase BH1302 from Bacillus halodurans. Although its biological function is unknown, BH1302 shows high sequence homology to the catalytic NodB homology domain of Streptococcus pneumoniae polysaccharide deacetylase PgdA (SpPgdA), which is an extracellular metal-dependent polysaccharide deacetylase with de-N-acetylase activity toward a hexamer of chitooligosaccharide N-acetylglucosamine, but not shorter chitooligosaccharides or a synthetic peptidoglycan tetrasaccharide. Both BH1302 and SpPgdA belong to the carbohydrate esterase 4 (CE4) superfamily. This family also includes many uncharacterized bacterial polysaccharide deacetylases.	3.74399e-100
NC_014650.1\|WP_013400752.1\|1728607_1728994_+\|VOC-family-protein	gnl\|CDD\|319937	cd08349, BLMA_like, Bleomycin binding protein (BLMA) and similar proteins. BLMA also called Bleomycin resistance protein, confers Bm resistance by directly binding to Bm. Bm is a glycopeptide antibiotic produced naturally by actinomycetes. It is a potent anti-cancer drug, which acts as a strong DNA-cutting agent, thereby causing cell death. BLMA is produced by actinomycetes to protect themselves against their own lethal compound. BLMA has two identically-folded subdomains, with the same alpha/beta fold; these two halves have no sequence similarity. BLMAs are dimers and each dimer binds to two Bm molecules at the Bm-binding pockets formed at the dimer interface; two Bm molecules are bound per dimer. BLMA belongs to a conserved domain superfamily that is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. As for the larger superfamily, this family contains members with or without domain swapping.	1.1127e-09
NC_014650.1\|WP_013399927.1\|1723491_1724232_+\|ATP-binding-protein	gnl\|CDD\|181681	PRK09183, PRK09183, transposase/IS protein; Provisional.	1.23731e-66
NC_014650.1\|WP_013400756.1\|1733374_1733671_+\|YwqI/YxiC-family-protein	gnl\|CDD\|375099	pfam17279, DUF5344, Family of unknown function (DUF5344). This is a Bacterial family of unknown function. Most of the members of this family are predicted to contain a coiled-coil region.	1.47833e-18
NC_014650.1\|WP_013400745.1\|1719255_1719888_-\|TetR/AcrR-family-transcriptional-regulator-C-terminal-domain-containing-protein	gnl\|CDD\|172294	PRK13756, PRK13756, TetR family transcriptional regulator.	6.20042e-36
NC_014650.1\|WP_003250225.1\|1732308_1732512_+\|copper-chaperone-CopZ	gnl\|CDD\|225328	COG2608, CopZ, Copper chaperone [Inorganic ion transport and metabolism].	1.55889e-20
NC_014650.1\|WP_013399926.1\|1721990_1723520_+\|IS21-family-transposase	gnl\|CDD\|226950	COG4584, COG4584, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	7.69214e-16
NC_014650.1\|WP_013400754.1\|1729895_1732289_+\|copper-translocating-P-type-ATPase	gnl\|CDD\|319783	cd02094, P-type_ATPase_Cu-like, P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B. The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NC_014650.1\|WP_013400743.1\|1717177_1718527_+\|putative-sulfate-exporter-family-transporter	gnl\|CDD\|225411	COG2855, COG2855, Predicted membrane protein [Function unknown].	9.75703e-38
NC_014650.1\|WP_013400738.1\|1713524_1714163_+\|SdpI-family-protein	gnl\|CDD\|227945	COG5658, COG5658, Predicted integral membrane protein [Function unknown].	1.09039e-25
NC_014650.1\|WP_041269467.1\|1729127_1729385_-\|excalibur-calcium-binding-domain-containing-protein	gnl\|CDD\|377566	pfam05901, Excalibur, Excalibur calcium-binding domain. Extracellular Ca2+-dependent nuclease YokF from Bacillus subtilis and several other surface-exposed proteins from diverse bacteria are encoded in the genomes in two paralogous forms that differ by a ~45 amino acid fragment, which comprises a novel conserved domain. Sequence analysis of this domain revealed a conserved DxDxDGxxCE motif, which is strikingly similar to the Ca2+-binding loop of the calmodulin-like EF-hand domains, suggesting an evolutionary relationship between them. Functions of many of the other proteins in which the novel domain, named Excalibur (extracellular calcium-binding region), is found, as well as a structural model of its conserved motif are consistent with the notion that the Excalibur domain binds calcium. This domain is but one more example of the diversity of structural contexts surrounding the EF-hand-like calcium-binding loop in bacteria. This loop is thus more widespread than hitherto recognized and the evolution of EF-hand-like domains is probably more complex than previously appreciated.	0.00701895
NC_014650.1\|WP_003250200.1\|1714830_1715184_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	1.29361e-19
NC_014650.1\|WP_003250220.1\|1729570_1729882_+\|metal-sensing-transcriptional-repressor	gnl\|CDD\|197392	cd10157, BsCsoR-like_DUF156, Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156. This domain family includes Bacillus subtilis CsoR (BsCsoR). CsoRs are Cu(I)-inducible, and regulate the expression of genes involved in copper homeostasis. BsCsoR regulates the copZA operon which encodes the copper chaperone CopZ, and the copper efflux P-type ATPase CopA. This family belongs to a larger superfamily that contains various transcriptional regulators that respond to different stressors such as Cu(I), Ni(I), sulfite, and formaldehyde, and includes Mycobacterium tuberculosis CsoR (MtCsoR), Thermus thermophilus CsoR, and Staphylococcus aureus CsoR. The latter three proteins do not belong to this family. CsoRs regulate the expression of genes involved in copper homeostasis. CsoRs form homotetramers (dimer of dimers). In MtCsoR, within each dimer, two Cys residues on opposite subunits, along with a His residue, bind the Cu(I) ion (forming a triagonal S2N coordination complex, C-H-C). These residues are conserved in the majority of members of this superfamily, including this family, and the conserved Tyr and a Glu residue that facilitate allosteric regulation of DNA binding for CsoRs are also well conserved.	4.92518e-42

>NC_014650.1|WP_013400745.1|1719255_1719888_-|TetR/AcrR-family-transcriptional-regulator-C-terminal-domain-containing-protein
MALRKEQIIEEALQLLNESGLEGVTLRKLAKRLGVQAPALYWHFNNKAALVNEMAEAILQTEFADLQPRSDDEPWQDWLIRTLNRLRKAMLSYTDGGRVVAGAHLSLTMAKISEVAIQSLHSAGISLREARLIVLAATHYTFGYVIEEQTTLPSPEEIKDFDFEQFKKEHPLMVQSIEEYFASGRTVDDLFNDGLKIIVGVYIQHKNPCQ
>NC_014650.1|WP_041269347.1|1719032_1719248_+|hypothetical-protein
MAFTCLARKRSGKRCTSAPSCMNKFRKAKANKTMKKGKFIGAAAEGMKKYIVHMIRAIILLPWPFLSRLKQ
>NC_014650.1|WP_013400744.1|1718617_1718968_+|hypothetical-protein
MKKNQWTCKQKICFIFEIFPRHAMPLKKLRHIRQMNSRSVRELHAFLSAHLEKIASMMDLLQEAHDHWIVYGKKDKIIMETDTYDFNEALDVLSSHGFNKDDYILRVEYERKWGML
>NC_014650.1|WP_013400743.1|1717177_1718527_+|putative-sulfate-exporter-family-transporter
MHKTNLSDERALPAIQSGWAEFIRKEDWWAVWIGLFLVILAVVLWSAGHSIKVLTAQIPKWGDIHTLTDALSHHFGSIVLLFITFSILFSIAVFFLRVKVSQFVSGFIVLFILSILINIFSSWEWAQRYTLEAPLIALAIGLVISNIIPIPDWFEAALRTELYVKVGIVLLGATLPFTLIVKAGPVAILQATIIAVVTFATIYFVGSKLGLDKRFAATLGAGGSICGVSASIAVGSSVKAKKEHVSVSISLVVIWAIVMIFALTFMIKWLKIPAGPAGAWIGTSEFADAAGITAASAFGDKALTAFTLMKVIGRDIFIGVWCFILAFISITRWEKKEEGTKADASEIWRRFPKFVLGFFAASAIVTIILASVSTASTDAINADIVAPIKELRTWAFTFCFLSIGLTTRFKQLTSVGWKPFVAFSSGVAVNVVLGYILSILLLGSYWANL
>NC_014650.1|WP_173662712.1|1716629_1716890_+|DUF3784-domain-containing-protein
MILLGYLIWTKKKLFLIAGYDEETFEGDKEKLAKAMGMFSIFVGILVFIFPFTLEYIGSFTGYIFAIIIVLGTMAMFIYVNILNRK
>NC_014650.1|WP_003250202.1|1715261_1716011_+|oxygen-insensitive-NADPH-nitroreductase
MNAVIETILQHRSIRKFEDRPLTDEQIRTIVECAQAASTSSFVQAYSIIGVKDKETKRKLAGLAGNQSYVEHNGHFFVFCADFHRHEVIGEMEQQDVLPSLESTEKFMVALIDAALAAQNAAIAAESMGLGICYIGGLRNNLPEVCKLLKVPKRVIPLFGLAVGYPAQQPDKKPRLPFEHIYHEETYEQDRTKFEAQLKQYNDIVSAYYEQRTNGKRRDTWTGQMANMLSSPVRTYMKEFVEGKGFNLR
>NC_014650.1|WP_003250200.1|1714830_1715184_+|winged-helix-turn-helix-transcriptional-regulator
MAALSQKHDVFQAIADPTRRTLLRLLADKEMPVTAISRHFPISRTAVSKHLRILADAGLVKERKVGRETRYRLEPTPLLELKEWLSFYERFWDNKMAMLKHYVEHGEEHMVDNGDDK
>NC_014650.1|WP_013400739.1|1714384_1714822_+|SRPBCC-domain-containing-protein
MTAEKNAANGMLPQICHTMVFQAPIQKVWKTVSTSEGLAAWFMPNDLQPVVGYEFHLNAGPFGMSPCKVIEVEPPHRLSFRWGKDWTVTFVLKELNKQQTEFTLIHSGWEANKVTEFGESHTIVRNRMDQGWAKLCQSLGAYVEE
>NC_014650.1|WP_013400738.1|1713524_1714163_+|SdpI-family-protein
MKKHWYFLLLLIISAGLSLWAYPRLPAEVPTHWNFSGEVDGYSSKLFAVLFGPILLIWIYGILIGVAKIDPRKENYEKFAGAYRIFVNASLTFFVCIHLAIIFSGLGYDVNMDWIVNIGLGLLFVILGNYMPKVKANYFMGIRTPWTLADEAVWARTHRFGGKVFFIGGIIIAVSPFAPSSIRAALLIASIACITIVPIVYSYAVYKKVADK
>NC_014650.1|WP_173662713.1|1713255_1713528_+|autorepressor-SdpR-family-transcription-factor
MNHVYKALADPTRRDILNLLKNKDLTAGEIADHFRISKPSISHHLNLLKQADLVHAEKKGQYIYYSINTTVLQDVLAWLLSLQEGKGEKE
>NC_014650.1|WP_013399926.1|1721990_1723520_+|IS21-family-transposase
MLAMPEIHYIKHLRENKDLSISEIARKTGLNWRTVKKYADGNIGGQKIMKKKRGMMYELGYGEIIDDWLEEDAKLPRKERRTNRTMFEQLQKEHGFPGSYRTVCAYIQERKPHLKAEKEKRYERLEHPPGEAQVDFGTMQVVKDGALEDKKLLILSFPHSNAGFAHPLPSENRECFLEGLKQLFHQAGGVPRRLRMDNLPAAVVTVGKGDNRQYTEAFLRFQAHYGFEVQPCNPASGHEKGNVERKVYYVRHRCFVPAPVVESDEQLTEWLRVKMIEDRSRLHYEKGVPIEELWKEDQKELKALPLDDLPIFSLDTVKVNKYGEITVDGEKWVIHQARVNQSLVVQKGWDRFICLSNQGEVVFEAPRPYMNQKQEIPWEEIFNDWEKKPRSVSYSRFFKYLPEKVQTYLTFRKEEVKQRVRGVRELLKSHTLKELDEWLNKEQRFDLAPHELKVLLEAKQQAYPEKWEETYTPSVFVNYETDLHLYDQRLCPSWEGGANRDDSGHQRDL
>NC_014650.1|WP_013399927.1|1723491_1724232_+|ATP-binding-protein
MTRDIKEICKALHLAYIADRFEEVPYETKEQFLRDVLALEVSSRQEAKRSKLIKKAKFRELKWLKDYEWSDHIHWPSTTTKEELCDLVFLERRQNVLLLGSPGTGKTHLATALGLKACEKGHEVRFFRVADLVAQLEEALKNGTLPRLKRQIETCELLILDELGYVPFQKQGSELLFHIIADCYERKSVIVTSNLEFGQWNRVFGDNRLTAALVDRLVHHAHIIAFTGESYRLRHALSSVKKISSN
>NC_014650.1|WP_013400749.1|1725777_1726383_-|polysaccharide-deacetylase-family-protein
MLYTKFYTSSQKAVALTFDDGPTKNVEKILPLLDKYHAKATFFVTGKELKKNPKLGKKIAESGHQIGNHTYSHQRMIFKKPSFIKQEIEMTNQLIRKTGYKGEIDFRPPYGKKLIGLPYYLKKHHIETITWSLEPDTYYSSVLDKVNYVNKHVKPGAIILLHPMYDNTGNELKTIEGILDSLSKKGYQFVTVNKLQKLHHQ
>NC_014650.1|WP_013400752.1|1728607_1728994_+|VOC-family-protein
MTVNIRLELFVKDLQRSVDFYKNVIRLDLSSQNESSAMFKTENLNLLLTKEDVISSNHYFSEIKTSRKGMGVEIILVVPDVQSYYQRICEMQIEVESELKQQEWGMTDFRLIDPDGYYLRITSPKMEN
>NC_014650.1|WP_041269467.1|1729127_1729385_-|excalibur-calcium-binding-domain-containing-protein
MTKQLITVFLSLELILGFSFDSFNYAEAAAKVKTYKNCTALNKDYRGGVRPLCLGKTKYKPYVSKALYDANKKLDRDKDFIARER
>NC_014650.1|WP_003250220.1|1729570_1729882_+|metal-sensing-transcriptional-repressor
MNHSEEHHPNPKMVPRTEEEIANIVKRLKRIEGQVRGVQKMVEDNRYCIDILIQISAIEAALHKVGLHLLERHVRHCVAKAIREGNGDESIQELMTVINQFSK
>NC_014650.1|WP_013400754.1|1729895_1732289_+|copper-translocating-P-type-ATPase
MGEKKHVTLHITGMTCAACSSRIEKVLNKMDGVEANVNLAMEKATIEYDPAKQSVRDIQEKIEKLGYGVATEKVMLDIEGMTCAACAARIEKGLQRMEGVERATVNLATNSAVVEYKEGIISVEAILEKIKKLGYKGQVRKEEEGAGVKEEQLKQKQRQLMISIVLSLPLLYTMIAHLPFDLGLPMPDWLMNPWVQLLFATPVQFYIGGPFYVGAYRALRNKSANMDVLVALGTSAAYFYSLAEAVKTIGNAHYMPNLYFETSAVLITLVLVGKYFEARAKGRTTEAISKLLSLQAKEALVVRDGKEVKVPLEQVAVGDTIIVKPGEKIPVDGIVIAGASAVDESMITGESIPVDKKEGDRVIGATINTTGTLTIQAEKVGKDTALANIVKIVEEAQGSKAPIQRLADVISGIFVPIVVGIAVLAFVVWYFFVTPGDLPKALEVGIAVLVIACPCALGLATPTSIMVGTGKGAEHGILFKGGEYLEETHKINAVLLDKTGTVTKGKPEVTDVIEFQEGMLDYAVSAESGSEHPLAQAVVEYGKRQQIPVKPLERFTALAGHGIEATVAGKRVLVGTRKLMKENNVDMSQHEAKMVQLETEGKTAMLVAIDGELAGIIAVADTIKENAKEAIRALKQMGIDVYMVTGDNARTAKAIAEQAGIDHVYAEVLPEDKASIVETLQREGKRVAMVGDGINDAPALAKADIGMAIGTGTDVAIETADVTLVGGDLAHIPKAVELSRKTMTNIRQNLFWALFYNTIGIPVAAAGLLEPWIAGAAMAFSSVSVVTNALRLKRVKL
>NC_014650.1|WP_003250225.1|1732308_1732512_+|copper-chaperone-CopZ
MTTTLQVQGMTCNHCKMAVTNALQELEGVNRVEVHLDKGTVDVDYDETKVSLDQLKEAIEEQGYDVK
>NC_014650.1|WP_013400755.1|1732955_1733300_+|DUF5082-domain-containing-protein
MTLASYYSLLRKKGEELQRVYHCEAKLLNSQAEFQAYQRFVMEPELSSNTWDGKKAEKFQQIRHEDMLESYQDMMEQQFSVVFDQLSAKANDIKEEINLIRQMIAQLEAQQAEQ
>NC_014650.1|WP_013400756.1|1733374_1733671_+|YwqI/YxiC-family-protein
MNGEIHIRFAQVEKKLRQLQNTTEALTISYLSSIAGENELDVVRKLDELNGELRHLLEKYKTLLLSNIQSTFHSLDAMKETDQAISSSIIGKSQRGEE

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Crispr_ID: NC_014650_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014650_9

1954247-1956204

Orphan

Consensus_repeat	Method
GTTTCAATTCCTTATAGGTAAGATAAAAAC	CRISPRCasFinder
GTTTCAATTCCTTATAGGTAAGATAAAAAC	CRT
GTTTTTATCTTACCTATAAGGAATTGAAAC	PILER-CR

29 spacers

The CRISPR arrays of NC_014650_9

>merge|NC_014650|9|1954247-1956204|CRISPRCasFinder,CRT,PILER-CR
GCTTTAATTTCTTATAGGTAAGATAAAAACTCCAAGGCAGCCTGTGCTGCTGTTTTCGAGATTACTTCGTTTCAATTCCTTATAGGTAAGATAAAAACGGAGCTAGTGGTTGATATTGATCTGGAATATTCATAGTTTCAATTCCTTATAGGTAAGATAAAAACGAGGATTTGAAAGTGAAAAATATGCAACAAAATCAGTTTCAATTCCTTATAGGTAAGATAAAAACTGTTATATAACATTCAAATTATCTTCCTTATTTTCTTGTTTCAATTCCTTATAGGTAAGATAAAAACTGTTATATAACATTCAAATTATCTTCCTTATTTTCTTGTTTCAATTCCTTATAGGTAAGATAAAAACTTGCGTGGCCGCAACAAAAACTGAATACGACTTTTTGTTTCAATTCCTTATAGGTAAGATAAAAACTCGCTCGCTTCTATCGGTTTATCTGTGATGGTTTAGTTTCAATTCCTTATAGGTAAGATAAAAACGGAAGAATGAATTTTTTCCATGGGAAAATCGCGGTGGTTTCAATTCCTTATAGGTAAGATAAAAACCATAACCACCCCTTTAGATTGTTGTTAAATCATTAGTTTCAATTCCTTATAGGTAAGATAAAAACAATTCCTTGTTGGAAAGTGTTTTTATTCGTTCTTTTAGGTTTCAATTCCTTATAGGTAAGATAAAAACCATAACCACCCCTTTAGATTGTTGTTAAATCATTAGTTTCAATTCCTTATAGGTAAGATAAAAACAATTCCTTGTTGGAAAGTGTTTTTATTCGTTCTTTTAGGTTTCAATTCCTTATAGGTAAGATAAAAACTTTTTCACTAATAAAAAAGTCTGGATAGGATTGTTGGTTTCAATTCCTTATAGGTAAGATAAAAACTGTTTTGTATAGAGTTAATGAAAGAACAAAGTTTTGTTTCAATTCCTTATAGGTAAGATAAAAACATAAAGTCTCGCTATCGTTCTCGAAACTTGATCGTGTTTCAATTCCTTATAGGTAAGATAAAAACGAACAACGAGCTTTTTTCAGAAAGAATGACAATCGAGTTTCAATTCCTTATAGGTAAGATAAAAACGGAGATGTGACAGGAAATGAAGTTTTTTTCGAAGTACAGTTTCAATTCCTTATAGGTAAGATAAAAACTCCGTATGCCGATCTTAAACGCTGGAGATTGGAAGGTTTCAATTCCTTATAGGTAAGATAAAAACCTTTCCTTTTTTGTATCGCGTGACTCTGTGTTCTGCAGTGTTTCAATTCCTTATAGGTAAGATAAAAACACCTTATCGGTTCTACGGGTTCCATCACTAGAAGAGTTTCAATTCCTTATAGGTAAGATAAAAACAAATGGAACACGGAAGGTATACTTGCCAATAAGTAGTTTCAATTCCTTATAGGTAAGATAAAAACCGTTCACGAATGTACGAATTTATATTAGTATTTTTTAGGTTTCAATTCCTTATAGGTAAGATAAAAACGTCGAATGACGAACGAAGTGAGGAATGAGACAAGCAGTTTCAATTCCTTATAGGTAAGATAAAAACTCGCCTTTTCTACATCCCAACCCTGCATTCGTACACGGGTTTCAATTCCTTATAGGTAAGATAAAAACCGATTTTGTGGAGTGAGGGGGAGAACAAAATGAACGAGTTTCAATTCCTTATAGGTAAGATAAAAACTATATTATTACTAGGATGACGAAAACGGGAAAAACGGGTTTCAATTCCTTATAGGTAAGATAAAAACGGAAATGGCTAGTCGAGGACTGAACGAGGATGAAATGTTTCAATTCCTTATAGGTAAGATAAAAACGGCTTGCGACCGCCTAACCGAGTCGGCTTGCGACCGCCGTTTCAATTCCTTATAGGTAAGATAAAAACATGCGTTCCATAGAGTCGACTTCGATGTAGGAGATCAAGTTTCAATTCCTTATAGGTAAGATAAAAAC

>NC_014650|9|9|1954247-1956204|CRISPRCasFinder
GCTTTAATTTCTTATAGGTAAGATAAAAAC	TCCAAGGCAGCCTGTGCTGCTGTTTTCGAGATTACTTC
GTTTCAATTCCTTATAGGTAAGATAAAAAC	GGAGCTAGTGGTTGATATTGATCTGGAATATTCATA
GTTTCAATTCCTTATAGGTAAGATAAAAAC	GAGGATTTGAAAGTGAAAAATATGCAACAAAATCA
GTTTCAATTCCTTATAGGTAAGATAAAAAC	TGTTATATAACATTCAAATTATCTTCCTTATTTTCTT
GTTTCAATTCCTTATAGGTAAGATAAAAAC	TGTTATATAACATTCAAATTATCTTCCTTATTTTCTT
GTTTCAATTCCTTATAGGTAAGATAAAAAC	TTGCGTGGCCGCAACAAAAACTGAATACGACTTTTT
GTTTCAATTCCTTATAGGTAAGATAAAAAC	TCGCTCGCTTCTATCGGTTTATCTGTGATGGTTTA
GTTTCAATTCCTTATAGGTAAGATAAAAAC	GGAAGAATGAATTTTTTCCATGGGAAAATCGCGGTG
GTTTCAATTCCTTATAGGTAAGATAAAAAC	CATAACCACCCCTTTAGATTGTTGTTAAATCATTA
GTTTCAATTCCTTATAGGTAAGATAAAAAC	AATTCCTTGTTGGAAAGTGTTTTTATTCGTTCTTTTAG
GTTTCAATTCCTTATAGGTAAGATAAAAAC	CATAACCACCCCTTTAGATTGTTGTTAAATCATTA
GTTTCAATTCCTTATAGGTAAGATAAAAAC	AATTCCTTGTTGGAAAGTGTTTTTATTCGTTCTTTTAG
GTTTCAATTCCTTATAGGTAAGATAAAAAC	TTTTTCACTAATAAAAAAGTCTGGATAGGATTGTTG
GTTTCAATTCCTTATAGGTAAGATAAAAAC	TGTTTTGTATAGAGTTAATGAAAGAACAAAGTTTT
GTTTCAATTCCTTATAGGTAAGATAAAAAC	ATAAAGTCTCGCTATCGTTCTCGAAACTTGATCGT
GTTTCAATTCCTTATAGGTAAGATAAAAAC	GAACAACGAGCTTTTTTCAGAAAGAATGACAATCGA
GTTTCAATTCCTTATAGGTAAGATAAAAAC	GGAGATGTGACAGGAAATGAAGTTTTTTTCGAAGTACA
GTTTCAATTCCTTATAGGTAAGATAAAAAC	TCCGTATGCCGATCTTAAACGCTGGAGATTGGAAG
GTTTCAATTCCTTATAGGTAAGATAAAAAC	CTTTCCTTTTTTGTATCGCGTGACTCTGTGTTCTGCAGT
GTTTCAATTCCTTATAGGTAAGATAAAAAC	ACCTTATCGGTTCTACGGGTTCCATCACTAGAAGA
GTTTCAATTCCTTATAGGTAAGATAAAAAC	AAATGGAACACGGAAGGTATACTTGCCAATAAGTA
GTTTCAATTCCTTATAGGTAAGATAAAAAC	CGTTCACGAATGTACGAATTTATATTAGTATTTTTTAG
GTTTCAATTCCTTATAGGTAAGATAAAAAC	GTCGAATGACGAACGAAGTGAGGAATGAGACAAGCA
GTTTCAATTCCTTATAGGTAAGATAAAAAC	TCGCCTTTTCTACATCCCAACCCTGCATTCGTACACGG
GTTTCAATTCCTTATAGGTAAGATAAAAAC	CGATTTTGTGGAGTGAGGGGGAGAACAAAATGAACGA
GTTTCAATTCCTTATAGGTAAGATAAAAAC	TATATTATTACTAGGATGACGAAAACGGGAAAAACGG
GTTTCAATTCCTTATAGGTAAGATAAAAAC	GGAAATGGCTAGTCGAGGACTGAACGAGGATGAAAT
GTTTCAATTCCTTATAGGTAAGATAAAAAC	GGCTTGCGACCGCCTAACCGAGTCGGCTTGCGACCGCC
GTTTCAATTCCTTATAGGTAAGATAAAAAC	ATGCGTTCCATAGAGTCGACTTCGATGTAGGAGATCAA
GTTTCAATTCCTTATAGGTAAGATAAAAAC

>NC_014650|9|4|1954247-1956204|CRT
GCTTTAATTTCTTATAGGTAAGATAAAAAC	TCCAAGGCAGCCTGTGCTGCTGTTTTCGAGATTACTTC
GTTTCAATTCCTTATAGGTAAGATAAAAAC	GGAGCTAGTGGTTGATATTGATCTGGAATATTCATA
GTTTCAATTCCTTATAGGTAAGATAAAAAC	GAGGATTTGAAAGTGAAAAATATGCAACAAAATCA
GTTTCAATTCCTTATAGGTAAGATAAAAAC	TGTTATATAACATTCAAATTATCTTCCTTATTTTCTT
GTTTCAATTCCTTATAGGTAAGATAAAAAC	TGTTATATAACATTCAAATTATCTTCCTTATTTTCTT
GTTTCAATTCCTTATAGGTAAGATAAAAAC	TTGCGTGGCCGCAACAAAAACTGAATACGACTTTTT
GTTTCAATTCCTTATAGGTAAGATAAAAAC	TCGCTCGCTTCTATCGGTTTATCTGTGATGGTTTA
GTTTCAATTCCTTATAGGTAAGATAAAAAC	GGAAGAATGAATTTTTTCCATGGGAAAATCGCGGTG
GTTTCAATTCCTTATAGGTAAGATAAAAAC	CATAACCACCCCTTTAGATTGTTGTTAAATCATTA
GTTTCAATTCCTTATAGGTAAGATAAAAAC	AATTCCTTGTTGGAAAGTGTTTTTATTCGTTCTTTTAG
GTTTCAATTCCTTATAGGTAAGATAAAAAC	CATAACCACCCCTTTAGATTGTTGTTAAATCATTA
GTTTCAATTCCTTATAGGTAAGATAAAAAC	AATTCCTTGTTGGAAAGTGTTTTTATTCGTTCTTTTAG
GTTTCAATTCCTTATAGGTAAGATAAAAAC	TTTTTCACTAATAAAAAAGTCTGGATAGGATTGTTG
GTTTCAATTCCTTATAGGTAAGATAAAAAC	TGTTTTGTATAGAGTTAATGAAAGAACAAAGTTTT
GTTTCAATTCCTTATAGGTAAGATAAAAAC	ATAAAGTCTCGCTATCGTTCTCGAAACTTGATCGT
GTTTCAATTCCTTATAGGTAAGATAAAAAC	GAACAACGAGCTTTTTTCAGAAAGAATGACAATCGA
GTTTCAATTCCTTATAGGTAAGATAAAAAC	GGAGATGTGACAGGAAATGAAGTTTTTTTCGAAGTACA
GTTTCAATTCCTTATAGGTAAGATAAAAAC	TCCGTATGCCGATCTTAAACGCTGGAGATTGGAAG
GTTTCAATTCCTTATAGGTAAGATAAAAAC	CTTTCCTTTTTTGTATCGCGTGACTCTGTGTTCTGCAGT
GTTTCAATTCCTTATAGGTAAGATAAAAAC	ACCTTATCGGTTCTACGGGTTCCATCACTAGAAGA
GTTTCAATTCCTTATAGGTAAGATAAAAAC	AAATGGAACACGGAAGGTATACTTGCCAATAAGTA
GTTTCAATTCCTTATAGGTAAGATAAAAAC	CGTTCACGAATGTACGAATTTATATTAGTATTTTTTAG
GTTTCAATTCCTTATAGGTAAGATAAAAAC	GTCGAATGACGAACGAAGTGAGGAATGAGACAAGCA
GTTTCAATTCCTTATAGGTAAGATAAAAAC	TCGCCTTTTCTACATCCCAACCCTGCATTCGTACACGG
GTTTCAATTCCTTATAGGTAAGATAAAAAC	CGATTTTGTGGAGTGAGGGGGAGAACAAAATGAACGA
GTTTCAATTCCTTATAGGTAAGATAAAAAC	TATATTATTACTAGGATGACGAAAACGGGAAAAACGG
GTTTCAATTCCTTATAGGTAAGATAAAAAC	GGAAATGGCTAGTCGAGGACTGAACGAGGATGAAAT
GTTTCAATTCCTTATAGGTAAGATAAAAAC	GGCTTGCGACCGCCTAACCGAGTCGGCTTGCGACCGCC
GTTTCAATTCCTTATAGGTAAGATAAAAAC	ATGCGTTCCATAGAGTCGACTTCGATGTAGGAGATCAA
GTTTCAATTCCTTATAGGTAAGATAAAAAC

>NC_014650|9|4|1954646-1956204|PILER-CR
GTTTCAATTCCTTATAGGTAAGATAAAAAC	TCGCTCGCTTCTATCGGTTTATCTGTGATGGTTTA
GTTTCAATTCCTTATAGGTAAGATAAAAAC	GGAAGAATGAATTTTTTCCATGGGAAAATCGCGGTG
GTTTCAATTCCTTATAGGTAAGATAAAAAC	CATAACCACCCCTTTAGATTGTTGTTAAATCATTA
GTTTCAATTCCTTATAGGTAAGATAAAAAC	AATTCCTTGTTGGAAAGTGTTTTTATTCGTTCTTTTAG
GTTTCAATTCCTTATAGGTAAGATAAAAAC	CATAACCACCCCTTTAGATTGTTGTTAAATCATTA
GTTTCAATTCCTTATAGGTAAGATAAAAAC	AATTCCTTGTTGGAAAGTGTTTTTATTCGTTCTTTTAG
GTTTCAATTCCTTATAGGTAAGATAAAAAC	TTTTTCACTAATAAAAAAGTCTGGATAGGATTGTTG
GTTTCAATTCCTTATAGGTAAGATAAAAAC	TGTTTTGTATAGAGTTAATGAAAGAACAAAGTTTT
GTTTCAATTCCTTATAGGTAAGATAAAAAC	ATAAAGTCTCGCTATCGTTCTCGAAACTTGATCGT
GTTTCAATTCCTTATAGGTAAGATAAAAAC	GAACAACGAGCTTTTTTCAGAAAGAATGACAATCGA
GTTTCAATTCCTTATAGGTAAGATAAAAAC	GGAGATGTGACAGGAAATGAAGTTTTTTTCGAAGTACA
GTTTCAATTCCTTATAGGTAAGATAAAAAC	TCCGTATGCCGATCTTAAACGCTGGAGATTGGAAG
GTTTCAATTCCTTATAGGTAAGATAAAAAC	CTTTCCTTTTTTGTATCGCGTGACTCTGTGTTCTGCAGT
GTTTCAATTCCTTATAGGTAAGATAAAAAC	ACCTTATCGGTTCTACGGGTTCCATCACTAGAAGA
GTTTCAATTCCTTATAGGTAAGATAAAAAC	AAATGGAACACGGAAGGTATACTTGCCAATAAGTA
GTTTCAATTCCTTATAGGTAAGATAAAAAC	CGTTCACGAATGTACGAATTTATATTAGTATTTTTTAG
GTTTCAATTCCTTATAGGTAAGATAAAAAC	GTCGAATGACGAACGAAGTGAGGAATGAGACAAGCA
GTTTCAATTCCTTATAGGTAAGATAAAAAC	TCGCCTTTTCTACATCCCAACCCTGCATTCGTACACGG
GTTTCAATTCCTTATAGGTAAGATAAAAAC	CGATTTTGTGGAGTGAGGGGGAGAACAAAATGAACGA
GTTTCAATTCCTTATAGGTAAGATAAAAAC	TATATTATTACTAGGATGACGAAAACGGGAAAAACGG
GTTTCAATTCCTTATAGGTAAGATAAAAAC	GGAAATGGCTAGTCGAGGACTGAACGAGGATGAAAT
GTTTCAATTCCTTATAGGTAAGATAAAAAC	GGCTTGCGACCGCCTAACCGAGTCGGCTTGCGACCGCC
GTTTCAATTCCTTATAGGTAAGATAAAAAC	ATGCGTTCCATAGAGTCGACTTCGATGTAGGAGATCAA
GTTTCAATTCCTTATAGGTAAGATAAAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_014650.1\|WP_013400878.1\|1937872_1940317_-\|DNA-topoisomerase-IV-subunit-A	unknown	unknown	gnl\|CDD\|235503
NC_014650.1\|WP_013400879.1\|1946385_1946643_+\|hypothetical-protein	unknown	unknown	unknown
NC_014650.1\|WP_013400884.1\|1958837_1960355_-\|IS21-family-transposase	unknown	unknown	gnl\|CDD\|226950
NC_014650.1\|WP_013399917.1\|1958130_1958850_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|224401
NC_014650.1\|WP_013400881.1\|1949903_1951361_-\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340831
NC_014650.1\|WP_013400880.1\|1948040_1949372_-\|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|223936
NC_014650.1\|WP_041269362.1\|1957365_1957569_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274342
NC_014650.1\|WP_003250613.1\|1960658_1961171_+\|RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274361
NC_014650.1\|WP_013400888.1\|1963958_1964600_+\|DUF2238-domain-containing-protein	unknown	unknown	gnl\|CDD\|378345
NC_014650.1\|WP_013400889.1\|1965584_1967009_-\|phosphomannomutase/phosphoglucomutase	unknown	unknown	gnl\|CDD\|100091
NC_014650.1\|WP_013400885.1\|1961154_1962120_+\|anti-sigma-factor-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|372728
NC_014650.1\|WP_003250597.1\|1946917_1947901_-\|NAD-dependent-epimerase	unknown	unknown	gnl\|CDD\|187563
NC_014650.1\|WP_049780659.1\|1953716_1954025_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224513
NC_014650.1\|WP_013400887.1\|1963227_1963509_-\|hypothetical-protein	unknown	unknown	unknown
NC_014650.1\|WP_013400890.1\|1967005_1968097_-\|glycosyl-transferase	unknown	unknown	unknown
NC_014650.1\|WP_013400886.1\|1962297_1962942_+\|hypothetical-protein	unknown	unknown	unknown
NC_014650.1\|WP_003250592.1\|1942443_1942863_-\|CoA-binding-protein	unknown	unknown	gnl\|CDD\|224745
NC_014650.1\|WP_003250590.1\|1940316_1942287_-\|DNA-topoisomerase-IV-subunit-B	unknown	unknown	gnl\|CDD\|235542
NC_014650.1\|WP_003250588.1\|1937510_1937876_-\|PilZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|377796
NC_014650.1\|WP_013400882.1\|1951362_1952457_-\|CotS-family-spore-coat-protein	unknown	unknown	gnl\|CDD\|131952

Protein	Function_ID	Function_description	E-value
NC_014650.1\|WP_013400878.1\|1937872_1940317_-\|DNA-topoisomerase-IV-subunit-A	gnl\|CDD\|235503	PRK05561, PRK05561, DNA topoisomerase 4 subunit A.	0
NC_014650.1\|WP_003250592.1\|1942443_1942863_-\|CoA-binding-protein	gnl\|CDD\|224745	COG1832, COG1832, Predicted CoA-binding protein [General function prediction only].	1.09542e-64
NC_014650.1\|WP_013400884.1\|1958837_1960355_-\|IS21-family-transposase	gnl\|CDD\|226950	COG4584, COG4584, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	5.80734e-37
NC_014650.1\|WP_013400881.1\|1949903_1951361_-\|glycosyltransferase-family-4-protein	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	4.36039e-72
NC_014650.1\|WP_013399917.1\|1958130_1958850_-\|ATP-binding-protein	gnl\|CDD\|224401	COG1484, DnaC, DNA replication protein [DNA replication, recombination, and repair].	1.14548e-57
NC_014650.1\|WP_013400880.1\|1948040_1949372_-\|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	gnl\|CDD\|223936	COG1004, Ugd, Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane].	0
NC_014650.1\|WP_041269362.1\|1957365_1957569_-\|hypothetical-protein	gnl\|CDD\|274342	TIGR02894, DNA_bind_RsfA, transcription factor, RsfA family. In a subset of endospore-forming members of the Firmcutes, members of this protein family are found, several to a genome. Two very strongly conserved sequences regions are separated by a highly variable linker region. Much of the linker region was excised from the seed alignment for this model. A characterized member is the prespore-specific transcription RsfA from Bacillus subtilis, previously called YwfN, which is controlled by sigma factor F and seems to fine-tune expression of some genes in the sigma-F regulon. A paralog in Bacillus subtilis is designated YlbO. [Regulatory functions, DNA interactions, Cellular processes, Sporulation and germination].	0.00164661
NC_014650.1\|WP_003250613.1\|1960658_1961171_+\|RNA-polymerase-sigma-factor	gnl\|CDD\|274361	TIGR02950, RNA_polymerase_ECF-type_sigma_factor, RNA polymerase sigma factor, SigM family. This family of RNA polymerase sigma factors is a member of the Sigma-70 subfamily (TIGR02937) and is restricted to certain lineages of the order Bacillales. This family encompasses at least two distinct sigma factors as two proteins are found in each of B. anthracis, B. subtilis subsp. subtilis str. 168, and B. lichiniformis (although these are not apparently the same two in each). One of these is designated as SigM in B. subtilis (Swiss_Prot: SIGM_BACSU) and is activated by various stressors.	4.33334e-21
NC_014650.1\|WP_013400888.1\|1963958_1964600_+\|DUF2238-domain-containing-protein	gnl\|CDD\|378345	pfam09997, DUF2238, Predicted membrane protein (DUF2238). This domain, found in various hypothetical bacterial proteins, has no known function.	2.75335e-61
NC_014650.1\|WP_013400889.1\|1965584_1967009_-\|phosphomannomutase/phosphoglucomutase	gnl\|CDD\|100091	cd03089, PMM_PGM, The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a bisphosphorylated sugar intermediate. The reaction involves two phosphoryl transfers, with an intervening 180 degree reorientation of the reaction intermediate during catalysis. Reorientation of the intermediate occurs without dissociation from the active site of the enzyme and is thus, a simple example of processivity, as defined by multiple rounds of catalysis without release of substrate. Glucose-6-phosphate and glucose-1-phosphate are known to be utilized for energy metabolism and cell surface construction, respectively. PMM/PGM belongs to the alpha-D-phosphohexomutase superfamily which includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Other members of this superfamily include phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the phosphoglucomutases (PGM1 and PGM2). Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.	0
NC_014650.1\|WP_013400885.1\|1961154_1962120_+\|anti-sigma-factor-C-terminal-domain-containing-protein	gnl\|CDD\|372728	pfam13791, Sigma_reg_C, Sigma factor regulator C-terminal. This family is the C-terminal domain of a sigma factor regulator, this may represent a sensory domain.	1.38821e-19
NC_014650.1\|WP_003250597.1\|1946917_1947901_-\|NAD-dependent-epimerase	gnl\|CDD\|187563	cd05253, UDP_GE_SDE_e, UDP glucuronic acid epimerase, extended (e) SDRs. This subgroup contains UDP-D-glucuronic acid 4-epimerase, an extended SDR, which catalyzes the conversion of UDP-alpha-D-glucuronic acid to UDP-alpha-D-galacturonic acid. This group has the SDR's canonical catalytic tetrad and the TGxxGxxG NAD-binding motif of the extended SDRs. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	0
NC_014650.1\|WP_049780659.1\|1953716_1954025_-\|hypothetical-protein	gnl\|CDD\|224513	COG1597, LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only].	3.44766e-12
NC_014650.1\|WP_003250590.1\|1940316_1942287_-\|DNA-topoisomerase-IV-subunit-B	gnl\|CDD\|235542	PRK05644, gyrB, DNA gyrase subunit B; Validated.	0
NC_014650.1\|WP_003250588.1\|1937510_1937876_-\|PilZ-domain-containing-protein	gnl\|CDD\|377796	pfam07238, PilZ, PilZ domain. PilZ is a c-di-GMP binding domain which is found C terminal to pfam07317. Proteins which contain PilZ are known to interact with the flagellar switch-complex proteins FliG and FliM. This interaction results in a reduction of torque generation and induces CCW motor bias. This domain forms a beta barrel structure.	3.12053e-08
NC_014650.1\|WP_013400882.1\|1951362_1952457_-\|CotS-family-spore-coat-protein	gnl\|CDD\|131952	TIGR02906, Spore_coat_protein_S, spore coat protein, CotS family. Members of this family include the spore coat proteins CotS and YtaA from Bacillus subtilis and, from other endospore-forming bacteria, homologs that are more closely related to these two than to the spore coat proteins YutH and YsxE. The CotS family is more broadly distributed than YutH or YsxE, but still is not universal among spore-formers. [Cellular processes, Sporulation and germination].	7.62105e-110

>NC_014650.1|WP_049780659.1|1953716_1954025_-|hypothetical-protein
MVNLMDYKKALERILMGKQRKIDVGRIDEEYCITVVGIGLDGKVAEVNNVSKYKKWFNFIRLGALSYVLSFLQVLLKYRPVNIQLNIDGEKLVFLCLVNCYC
>NC_014650.1|WP_013400882.1|1951362_1952457_-|CotS-family-spore-coat-protein
MESIFIEPWEVDESTHEFFIPDYINELADKVLKHYDFSVESIQVVTTKPDKGGAIWKLETSAGPKSLKLLHRRPTRSLFSLGAQEYLVDVRHARVPPIVKTKDGTNYVEAGGKLWFVAEWIESLTPVTKDLEGAKLLCSALGEFHRLSKGYVPPPQVETASRLHKWRRNYEKIIYKMDWFRNIAKAYNELPASSYLLNVIDEFEEQARRSLERLDQSSYFELIKHGNAYWGLVHQDYGWSNGQMGRDGMWIIDLDGVAFDLPIRDLRKLISGTMADLYKWDAKWIREMIKAYHKENPISPELYEILMIDLSLPNEFYKNIKEVVYDPEMFLNEQTVQLMKTIIDTDQTKWPVLAEIQNDWKEVE
>NC_014650.1|WP_013400881.1|1949903_1951361_-|glycosyltransferase-family-4-protein
MKILMICTEKLPVPPVRGGAIQTYISGVLPYLSKHHDITVLGISDPSLPDQETLDGVHYVRVPGKIFEIYREGVVRYIESNSFDLIHIFNRPRLVLPVRQAAPHAKITLSMHNDMFNIEKIDPEEATAVLEEVSSIVTVSDYVGNVIRQLYPQASPKIRTIYSGVDTERFLPGSHPKMQETRKAIRKAHGLENKTVILFAGRLSRNKGVDKLVRALPELSKKFKDLALVIVGSNWFSQNNVTDYVAYVRALVKKLPVPVVTTGFVAPDEIQNWFAAADLFVCTSQWQEPLARVHYEAMAAGLPIVTTARGGNPEVIFSEENGLVVENPEDPSNFAEKIAKILSDKSLMKKMGERGRELAVSRYKWERVASELLEVWNQAVHMTSTTAVEQDSTDKTNQTGAKELEYVIEHNSETKKEDEKAAMEQDSAEKISEDEVNNTEVEEPESVARIKIIDVDEETIRNSIWFSSTYKRGRKRNNRRGRKGS
>NC_014650.1|WP_013400880.1|1948040_1949372_-|UDP-glucose/GDP-mannose-dehydrogenase-family-protein
MNIAMIGAGYVGTATSVAFAEYGHKVYVIERDGEKLKKLKMSVLPFFEEGMEELFKKHSANGNLLFFHYIEEVIDQCEILMITVGTPSLPNGEADLSYVEEAARQIGRSMNEYKAIVIKSTVPVGTGDKINKIIKTELKKRNKEISFDLISNPEFLREGKALQDALHPERIVIGCETEKARQVMKELYSGINSPILFTTVKDAEMIKYASNAFLATKISFINELARLCDKVGANVIQVAKGMGLDSRIGPQFLQAGIGFGGSCFPKDVKALLALASAEKTPLQILQAVLDVNETQAQWFMEKVKKALGSLSRKRIAVLGLTFKPQTDDIREASSLKIIHYLLQNNACITAYDPQGTEHVKKIYPAINYAKTTLEALNGADAALIVTEWKEIIEIDWKKAKSILSQPFVFDGRNCLDASVMLELGYHYEGVGTPNLDERINGSF
>NC_014650.1|WP_003250597.1|1946917_1947901_-|NAD-dependent-epimerase
MQNNAKYIFITGCAGFIGFHLTKRLLDEGFSVLGMDDMNDYYDTSLKYDRLKIVMKHPHFRFVKGSIENIELLEKLFSQYDVDTVVNLAAQPGVRYSLKNPHKYIQANVVGFANILECCKKHKIRHLIYASSSSVYGNNKNAPFSVADRTDSPVSLYAATKKANELMAYTYSHLYRLPTTGLRFFTVYGPWGRPDMALFKFANAIVKQQPIEIYNYGNMKRDFTYVDDVTESILRLIDKGPSTESPYKIYNIGNNQPVQLNYFIEVLEEHLGKKAIKKLLPMQPGDVPETFADIDELVKDINYKPKVSIEEGIKRFVEWFKDYYKIN
>NC_014650.1|WP_013400879.1|1946385_1946643_+|hypothetical-protein
MNFLKDPNKMRFISLIVAVIGLFLILNSPRLGSISTSSWLRSVGGSEDSQKYLQMLEGYIDSYRVIGSIFLFTGLFSILNKNDNK
>NC_014650.1|WP_003250592.1|1942443_1942863_-|CoA-binding-protein
MPITNPSREEIGEILRKAKRIAVVGLSDNPERTSYTVAKAMKDAGYEIIPVNPMIEEWEGIKAVKKLTDIDGHVDIVNVFRRSEHLPEIAREFVQIDADVFWAQLGVVNEEAYEFLKEKGYTVVMDRCIKVEHALTQQH
>NC_014650.1|WP_003250590.1|1940316_1942287_-|DNA-topoisomerase-IV-subunit-B
MTKPSVYEYNDDAIQVLEGLEAVRKRPGMYIGSTDSRGLHHLVYEIVDNSVDEALAGYGNYILVKIHKDNSVTVLDEGRGMPTGMHKLGKPTPEVILTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSEWLVVTIHRDGFIYQQRFENGGKPVTTLEKIGTTNKTGTIIQFKPDPAIFSTTTFNYETLSERLRESAFLLKGLKIELIDERTGMSDVFHYENGIKAFVEYLNEDKDVLHPVVYFEGEQNGIEVEFAFQFNDGYSENVLSFVNNVRTKDGGTHEAGAKTAMTRVFNEYARKNGLLKEKDKNLEGTDIREGLSAIVSVRIPENLLQFEGQTKGKLGTSEARSAVDAIVSEHLTYFLQENPDVSTMLIKKAIRAYQAREAARKAREEARSGKKRKGKETVLSGKLTPAQSRNPQKNELYLVEGDSAGGSAKQGRDRRFQAVLPLRGKVINTEKAKLADILKNEEINTIIHAIGGGVGPDFSLDDINYDKVIIMTDADTDGAHIQVLLLTFFYRYMRPLIEAGKVYIALPPLYKVSKGSGKKEIVEYAWTDAQLKEITKKLGKGYTVQRYKGLGEMNAEQLWETTMNPETRTLIRVRIEDAARAERRVTTLMGDKVEPRRKWIEANVAFGLEDDPNILDNEHVFIAGGDY
>NC_014650.1|WP_013400878.1|1937872_1940317_-|DNA-topoisomerase-IV-subunit-A
MAERLLDLPLEDVLGDRFGRYSKYIIQERALPDARDGLKPVQRRILYAMYIDGNTADKPFRKAAKTVGNVIGNFHPHGDSSVYEAMVRMSQDWKLRNILIEMHGNNGSIDGDPPAAMRYTEARLSSIALELLRDIEKQTVEFVPNFDDTTNEPVVLPAMFPNLLVNGSTGISAGYATEIPPHHLGEVIDAVIMRIDKPKCTVDELMTVIQGPDFPTGGIIQGKDGIKKAYETGKGKIIIRGKAAIEQGKGGKKQIIITELPYEVNKANLVKKIDELRFDKKLDGIADVRDETDRTGLRIVIELKKDADAEGILNYLYKNTDLQVPYSFNMVAIHERRPKLLSLPELLDAYIEHRKEVVTNRSQYELKKAYERQHIVEGLVKALSILDEVIATIRASRDKRDAKDNLIAKYEFTEAQAEAIVSLQLYRLTNTDITALQQEAEQLEKTIQELTTILNSEKKLLAVIKRELKAMKKQYADERRTVIEDEIEELKINLEVMIPSEDVIVTVTKEGYVKRTSYRSYNASNGQDFGMKESDRLLSQMEMNTTDVLLLFTRKGNYLYCPVYELPDIRWKDVGQHISNLIPLDRDDDLIAAVPVKRFDEPLSLVFVTKQGMVKRTELGQYKVQRYTRPLVAINVKEGDEVIHVHATDGQQSLLLITNQGYGLWFDEAEISMVGVRAAGVKGINLKEGDHVVSAHPIVAEGEQYLVIVTQRGAIKKMPLSEFTKTSRAKRGVVMLRELKTNPHRIVASVLTDKNDEMLFIRTETGEIETLSVSSLRVADRYSNGSFIIDSDEAGNVIDMWKQPFNILGKEEMR
>NC_014650.1|WP_003250588.1|1937510_1937876_-|PilZ-domain-containing-protein
MKFKRQEAFRYQFGQPLPCTFRLVHDDEKYIEIEEKNAHIHDISPRGMKLETPARIPCERGQEIEIIFTLNDVEFCFLGKIVWERPFARMHYYGVRLLISNEQGEKLISEIKRHAALHRKR
>NC_014650.1|WP_041269362.1|1957365_1957569_-|hypothetical-protein
MGQLQQTVTKLQLEKESLQKEFVAIQENYKTLIGIMGWSKKWLCLRWAYTKSKIPEGENGEIEKIEK
>NC_014650.1|WP_013399917.1|1958130_1958850_-|ATP-binding-protein
MEQMIKEYAKRLKLSWIPANYHTIHAETNEEFLLKLFEREVQHRDERRINLLLKQATLPKIPNKPYDWREIQLAPGITKDYILEGEFTKNQENLIFYGGVGTGKTFLSTLIALNLMKKQGKRVKFYTAASIVNALLEANEKGDLGKFLNQIEKLDLLILDELGYIPLHKQGAELLFQVISMCYETKSIIVTTNLPFSQWNNVFGDPILTEAVIDRLIHHSHLIIFNGESHRYKDSISQR
>NC_014650.1|WP_013400884.1|1958837_1960355_-|IS21-family-transposase
MLAVAEIHYIRYEANQKGCSYSDIAKRMNRDPRTVKKYAEMEDFNPSKVKQTRKAKVMDPVKPILDQWIKEDLTKKKKYRRTAKRMYEILKEEYGFTGSDRSVRLYVSKRKQELLEQSEPAALPLESKPATAQVDFGEAPFLYQGKYVDFPYLVVSFPYSNAAYVQVMPAQNQECFLEGLKRIFHYMGRVPRVIRFDNLSPAVKTILPNGERELTETFQRFVLHYGFECEFCNPASGNEKGNVESKVKYIRNHFFLPEQTIYQLESFNESLWEKCEKDWNRPHYEKERLIAELFEEEQALFLQLPAKEFECVRYEQVTADKYGFIHLENNLYSTSPRFAKQKVLAKISYHEIAILTEEHELIIKHERLYGTKQKSMKWQPYLTLMAKRPNALKYTDFYEKMPEEWKNYFSNCTVQEKKEALQLLAVLLKEHDFEVSTQALRIASQYGHPKVESIKQVFYQLINGRGIREPIQPKKHVPDMPEAIRGVRHYDRLFESQGDVASWNK
>NC_014650.1|WP_003250613.1|1960658_1961171_+|RNA-polymerase-sigma-factor
MNDFELGEKLHEQLERVKVYLLKMGASLQDAEDITQETAYKFLTYIDSVNIENVESWLFRVSVNQYYDLCRKHNRQKNISLKFNYKELFEEFTPEKAVLQKEFEKDIYILLDRLKPKYAQFLILKYSIGLKLTEIAALYDMKVDSVKTIIHRARKQFIEEYRRHQNERRE
>NC_014650.1|WP_013400885.1|1961154_1962120_+|anti-sigma-factor-C-terminal-domain-containing-protein
MNEENEFLPQDPDFRKLVKKAKRNSALRIVVISLIISIIVVIAFYFVGNSIMINKVNEEVRNDAIWHSIHGANIEEQGTSINYSLFSATSKTEFIKKVNGIPVPWVPVEKEYSIFGQSKIIISKGASGTGNVDEKRIPMYFNGERVIEFIHPKVNSSLFDDRSIVSSMDDDKVIELALSFDKGYKVTDVQKIFNKNISWFWVDTYSESDIKNYNNFIKETGKDFTIIGDDAIGFHYINQPESKWGAEYFIRSLKELKQNGSYKDVADKIIQNITHNNKEKLSAENLEIIGVVITGTPSEIEKFNNVPFVRATSLGVTADRY
>NC_014650.1|WP_013400886.1|1962297_1962942_+|hypothetical-protein
MKKIIKIGIGVFGIVAFGIGLLIFVFLQSMKADEDEVKKVKIQAQGYIKNTFKDEIVIYDTLFDNMGNFPTFDYAAKAENKKDNTQFLIYYNEETKQMEDTYIAEKWEKELENNIRPYIEQKLGTLDEFWVEYDERAGITYNVNPNKPSSYKEYDAAPTILISVPRKPDKKDEEILNEIVAFLQKDVGLKHGTVSMSYIKNGAPLDDKEWFKTF
>NC_014650.1|WP_013400887.1|1963227_1963509_-|hypothetical-protein
MKNIMPKLSLTVIIAALLFFFMSFFMAVFLGLIIPAPIIRIIINLGIIVSFVLALLSPKGKWKNAALTVVIIIGLLYLIGIELMGFLFRGNGF
>NC_014650.1|WP_013400888.1|1963958_1964600_+|DUF2238-domain-containing-protein
MKHDGSRKIHLFLLLVIIAVFIWSAIKPASYLTWALEVSPAVVGLIIVITIYYRFRFTTLSYVIMAVLAILMFIGGHYIYSKVPLFDWIKDTYDLKRNHYDRFGHLLKGLFAIVLREILLRKTPLTKGTWLFAIVVSMSLAIAALYEIIEWLVSKISKGGEASKNFLGIQGDIWDTQWDMLCSLTGSIVALLIFSKLHDKLLKKEIRTSNAQH
>NC_014650.1|WP_013400889.1|1965584_1967009_-|phosphomannomutase/phosphoglucomutase
MNFSMAQQQFVLPTHVFKEYDIRGRAGEELDENFAYLLGLAFAEMVRQAGEQKVVVGHDNRISSPTLHRALIAGLSQASCQVIDIGLVTTPMFYYSLEYTNVPCGIIVTASHNPGDENGFKIAMNKTTIYGERIQELRRIMERLQTQGVNRSDSWKEGYVEKLDIKPAYLEMLENKIKLGARKLKVVVDCGNGTASIIAPKALEAWGCEVVPLYCESDPTFPNHHPDPVVPENLQDLIDTVRREKADVGLAFDGDGDRLGVVDEEGNIRWGDQLMILFWREILRRYPGADAPVEVKCSQALVEEIERLGGKPFFHRTGHSHIKATLRSRPEIPFAGEMSGHLFFNDEFYGYDDALYAAGRLLRILSSDDRKLSQLFADVPSYHATPETRVPCPEEKKAEAIAAVKQRFADSHEVVDVDGARIQFKDGWGLVRPSNTQPILVLRAEAASPEALADIKQQLADVLSKPPLNLNITW
>NC_014650.1|WP_013400890.1|1967005_1968097_-|glycosyl-transferase
MSPAAVKFDHLERLTDDTGLLEHCLGRIPRRREGYTTDDNARAIWACVEWIDLLKGDESGERRRLYRLLDRYLAFLLWAQREDGTFQNNFHFDRTPEAEEHSDDCLGRSIWAAAAAYVSLDDEARRRVVAEIFRQALPASGGMQFLRGQAWGLAACCLMLSKRNNGSALPSGVAAAELANLADNFEQRLLAAYRAHRTDDWHWFEPQITYANGLLPWALFVAYRYHGRDETLQVAKESLDFLAAKMSGQNGVIRPVGNRGWCSIDRRADWDQQPVDVMKLALAAREAYRALGDETYRELVRRCRNWFYGDNDLGTPLADPSDGSCCDGLNPDGPNPNRGAESTLSYLLTEAMAQSLQLEVVSR

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Crispr_ID: NC_014650_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014650_10

2449843-2449947

Orphan

Consensus_repeat	Method
CTCTTAACGAGGTCATCTTAAAAAAAGAATAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014650_10

>merge|NC_014650|10|2449843-2449947|CRISPRCasFinder
CTCTTAACGAGGTCATCTTAAAAAAAGAATATACGGTGCAAATTCGGGATACTTTAGAATGGCTGTTTCAATCCTCTTAACGAGGTCATTTTAAAAAAAGAATAT

>NC_014650|10|10|2449843-2449947|CRISPRCasFinder
CTCTTAACGAGGTCATCTTAAAAAAAGAATAT	ACGGTGCAAATTCGGGATACTTTAGAATGGCTGTTTCAATC
CTCTTAACGAGGTCATTTTAAAAAAAGAATAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_014650.1\|WP_013401167.1\|2454985_2455273_+\|hypothetical-protein	unknown	unknown	unknown
NC_014650.1\|WP_013401162.1\|2444330_2444984_-\|copper-amine-oxidase-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|377924
NC_014650.1\|WP_003251391.1\|2445353_2446346_-\|acryloyl-CoA-reductase	unknown	unknown	gnl\|CDD\|176249
NC_014650.1\|WP_013401161.1\|2443994_2444315_-\|hypothetical-protein	unknown	unknown	unknown
NC_014650.1\|WP_003251387.1\|2443055_2443991_-\|FAD:protein-FMN-transferase	unknown	unknown	gnl\|CDD\|376782
NC_014650.1\|WP_013399927.1\|2455302_2456043_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|181681
NC_014650.1\|WP_013401168.1\|2459033_2460644_-\|PucR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|377939
NC_014650.1\|WP_003251384.1\|2441829_2442498_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_014650.1\|WP_013399926.1\|2456014_2457544_-\|IS21-family-transposase	unknown	unknown	gnl\|CDD\|226950
NC_014650.1\|WP_003251393.1\|2449127_2449415_+\|hypothetical-protein	unknown	unknown	unknown
NC_014650.1\|WP_003251403.1\|2461240_2461474_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236179
NC_014650.1\|WP_013401164.1\|2449579_2449801_-\|hypothetical-protein	unknown	unknown	unknown
NC_014650.1\|WP_003251395.1\|2450614_2451967_-\|aspartate-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|181078
NC_014650.1\|WP_013401163.1\|2447548_2448853_+\|acetamidase/formamidase-family-protein	unknown	unknown	gnl\|CDD\|376984
NC_014650.1\|WP_013401165.1\|2452055_2453522_-\|CoA-acylating-methylmalonate-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143404
NC_014650.1\|WP_083787396.1\|2454731_2455025_+\|hypothetical-protein	unknown	unknown	unknown
NC_014650.1\|WP_003251385.1\|2442504_2443053_-\|ferric-reductase-like-transmembrane-domain-containing-protein	unknown	unknown	gnl\|CDD\|225338
NC_014650.1\|WP_013401160.1\|2440508_2441837_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NC_014650.1\|WP_049780667.1\|2450308_2450530_+\|hypothetical-protein	unknown	unknown	unknown
NC_014650.1\|WP_083787428.1\|2454285_2454600_+\|DUF5082-domain-containing-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_014650.1\|WP_013401162.1\|2444330_2444984_-\|copper-amine-oxidase-N-terminal-domain-containing-protein	gnl\|CDD\|377924	pfam07833, Cu_amine_oxidN1, Copper amine oxidase N-terminal domain. Copper amine oxidases catalyze the oxidative deamination of primary amines to the corresponding aldehydes, while reducing molecular oxygen to hydrogen peroxide. These enzymes are dimers of identical subunits, each comprising four domains. The N-terminal domain, which is absent in some amine oxidases, consists of a five-stranded antiparallel beta sheet twisted around an alpha helix. The D1 domains from the two subunits comprise the 'stalk' of the mushroom-shaped dimer, and interact with each other but do not pack tightly against each other.	3.86046e-15
NC_014650.1\|WP_003251391.1\|2445353_2446346_-\|acryloyl-CoA-reductase	gnl\|CDD\|176249	cd08289, MDR_yhfp_like, Yhfp putative quinone oxidoreductases. yhfp putative quinone oxidoreductases (QOR). QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR actin the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site, and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	0
NC_014650.1\|WP_003251387.1\|2443055_2443991_-\|FAD:protein-FMN-transferase	gnl\|CDD\|376782	pfam02424, ApbE, ApbE family. This prokaryotic family of lipoproteins are related to ApbE from Salmonella typhimurium. ApbE is involved in thiamine synthesis. It acts as an FAD:protein FMN-transferase, catalyzing the attachment of an FMN residue to a threonine residue of a protein via a phosphoester bond in such bacterial flavoproteins.	4.37603e-52
NC_014650.1\|WP_013399927.1\|2455302_2456043_-\|ATP-binding-protein	gnl\|CDD\|181681	PRK09183, PRK09183, transposase/IS protein; Provisional.	1.23731e-66
NC_014650.1\|WP_013401168.1\|2459033_2460644_-\|PucR-family-transcriptional-regulator	gnl\|CDD\|377939	pfam07905, PucR, Purine catabolism regulatory protein-like family. The bacterial proteins found in this family are similar to the purine catabolism regulatory protein expressed by Bacillus subtilis (PucR). PucR is thought to be a transcriptional activator involved in the induction of the purine degradation pathway, and may contain a LysR-like DNA-binding domain. It is similar to LysR-type regulators in that it represses its own expression. The other members of this family are also annotated as being putative regulatory proteins.	3.84291e-44
NC_014650.1\|WP_003251384.1\|2441829_2442498_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	3.89754e-81
NC_014650.1\|WP_013399926.1\|2456014_2457544_-\|IS21-family-transposase	gnl\|CDD\|226950	COG4584, COG4584, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	7.69214e-16
NC_014650.1\|WP_003251385.1\|2442504_2443053_-\|ferric-reductase-like-transmembrane-domain-containing-protein	gnl\|CDD\|225338	COG2717, COG2717, Predicted membrane protein [Function unknown].	0.00117786
NC_014650.1\|WP_003251403.1\|2461240_2461474_-\|hypothetical-protein	gnl\|CDD\|236179	PRK08188, PRK08188, ribonucleotide-diphosphate reductase subunit alpha; Validated.	0.00721254
NC_014650.1\|WP_003251395.1\|2450614_2451967_-\|aspartate-aminotransferase-family-protein	gnl\|CDD\|181078	PRK07678, PRK07678, aminotransferase; Validated.	0
NC_014650.1\|WP_013401163.1\|2447548_2448853_+\|acetamidase/formamidase-family-protein	gnl\|CDD\|376984	pfam03069, FmdA_AmdA, Acetamidase/Formamidase family. This family includes amidohydrolases of formamide EC:3.5.1.49 and acetamide. Methylophilus methylotrophus FmdA forms a homotrimer suggesting all the members of this family also do.	1.35913e-58
NC_014650.1\|WP_013401160.1\|2440508_2441837_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	2.41181e-59
NC_014650.1\|WP_013401165.1\|2452055_2453522_-\|CoA-acylating-methylmalonate-semialdehyde-dehydrogenase	gnl\|CDD\|143404	cd07085, ALDH_F6_MMSDH, Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2. Methylmalonate semialdehyde dehydrogenase (MMSDH, EC=1.2.1.27) [acylating] from Bacillus subtilis is involved in valine metabolism and catalyses the NAD+- and CoA-dependent oxidation of methylmalonate semialdehyde into propionyl-CoA. Mitochondrial human MMSDH ALDH6A1 and Arabidopsis MMSDH ALDH6B2 are also present in this CD.	0

>NC_014650.1|WP_013401164.1|2449579_2449801_-|hypothetical-protein
MEIETLSLFGVENGIDEAALLLCFRRVQGDIQKESCCMVEYGMALFFLFAAFAADMAGVCPGAMRPDWLLSVW
>NC_014650.1|WP_003251393.1|2449127_2449415_+|hypothetical-protein
MIVHELIGTETLFAGQLKEGYYVIREKYNKLDVQPQDVDSFQQIDCGTEDIITVVFDPGNDYSLICLDTYTFQSKFPSLSELQQTLKTKHEDLFQ
>NC_014650.1|WP_013401163.1|2447548_2448853_+|acetamidase/formamidase-family-protein
MEAKQTIFVNEFTNGILDPNGEMLGPVQDGGYIVANTTPGCWGPMITPCIRGGHEVTKPVFVEGAEVGDAIAIKIKSIRVTSIATSSGNDKPIEGRFVGDPFVAVKCPECGTMYPETKIEGIGQEAIRCANCGADVTPFVFTNGYTMAFDSNKQVGITLHKEAAEHIAQQGRYYMATPDNSVQNPIVTFAPHDLVGTVARLRPFLGQLGTTPARPFPDSHNAGDFGQFLIDAPHEYGITKEQLEDRTDGHMDINRVREGAVLICPVKVRGGGVYLGDMHAMQGDGEIAGHTTDVAGIVTLQVKVIKGLTIDGPILLPVAEDLPYLAKPITKKEKEIALDLAQTWGVKKLEESLPISFIGTGANLNEATENGLQRAAKVLGISVPEVMNRATITGAIEIGRHPGVVTVTFLCPVHYLDEIGLTTLVRDQYRDVLE
>NC_014650.1|WP_003251391.1|2445353_2446346_-|acryloyl-CoA-reductase
MSEFKALVVNKTDTDFTVNVQAVSMDDLPEGEVLIKVQYSSVNYKDGLACIPDGKIVKTYPFIPGIDLAGSVVSSSDPRFKEGDEVVATGYEIGVTHYGGFSEYARIPGDWLVPLPKGLTLKEAMALGTAGFTAALSIHRLEENGLSPDKGKVLVTGATGGVGSLAVSMLAKRGYEVVASTGKETEHEYLRGLGAKEILSREDVCAEKIRPLDKQHWAAAVDPVGGRTLATVLSHIRYGGAVAVSGLTGGTDVPTTVFPFILRGVSLLGIDSVYCPMELRKQIWERMASDLKPDKLLQSIAQEITLEQLPEALANILKGKVRGRTVVKLP
>NC_014650.1|WP_013401162.1|2444330_2444984_-|copper-amine-oxidase-N-terminal-domain-containing-protein
MRKIAFGLCVCFLIFTAYSSQIFPVYADDHEKYKHKLEEGAGDWDEDDYDHEDEEEHKDRYHSEEYDWKNIMQEERTSVKREYWYKWSRSADLPDEYVATPISSRQTVPIYLESKAPLYTTAIPMQGQIFVPLEDTAEYLGASVIIYPNSQIGEIQLGDRHLIVKNGTRVVYENMRKTPMPLPVFSEKEKLYIPISVLANGLGFQVTWTEQQQIRIY
>NC_014650.1|WP_013401161.1|2443994_2444315_-|hypothetical-protein
MKTNKWVKWVVGLGGVTVFTTFLQLVNDTETAHQQNDSYRSTAANKTAEFENSTNDETMRQHEQELMSLDWTEGNWDVEYSDEVIIATPKERNYPLPPSENRTRRS
>NC_014650.1|WP_003251387.1|2443055_2443991_-|FAD:protein-FMN-transferase
MNEKQSLIFNGMGTTIKAEVMACKPSLDWKELIQTWFATFESICSRFRRDSELTKLNQSPVSKLIPIHPVLYDVLQLAFQYAMKTEFYFNPFVGTILKNMGYEQPFQKRRAFHEYKENENGYRVPSNKSLSFFPDQKAVMKHINEEIDLGGIGKGWSVDKAYRLLRDQGVHQGVIDAGGDMVIWGDSSRKIGVANPFAENEDIAQFVISAGAVATSNILYRSWNIKGRTFHHIINGQTGKNPESDVVQATVLASHVSEAEVIAKILCMLPAQEGIQWLKKHFPKAACIIVNKNGQLLITPSISRYVERLVI
>NC_014650.1|WP_003251385.1|2442504_2443053_-|ferric-reductase-like-transmembrane-domain-containing-protein
MITFSTWEWIRASGLSAYFLLFLSVCFGLIQNMNIINRNIRNVLFLMHQTAGWFAFLFAFFHGLLLYFDDYQPFSIREIFIPFLANYQPFFTGLGIIAFYSMFLIFVTTDLMKKVGRNIWKTVHLLILPSFILVSIHGLFIGTDTEETWGKNIYASAIFCFSILTVFRFLSKITVKNNRNRG
>NC_014650.1|WP_003251384.1|2441829_2442498_-|response-regulator-transcription-factor
MYILLAEDDTRLGKLIVYMLKKEKHTVDWVQDGDDAYYFAKHTHYDLLILDWMMPSKEGTEVCKALRKDGFNGAILMLTAKDAVEDRVAGLDCGADDYVVKPFEFSELFARIRALSRRIAQPFQAEELSFGNLSLNLNEYSIKKGNKKIQLTNREFQLMELFMRHPNQILPRELIIERIWGLDADISSNNIDSFIRLLRKKLGDDGTLIQNIRGVGYKLSDE
>NC_014650.1|WP_013401160.1|2440508_2441837_-|HAMP-domain-containing-histidine-kinase
MNDKMFKQTRFRLTLLFTSLIVVFLISFTAVSYIVVSSLITSKQKQQVAALAEEEYMEHKSDLLNWHNHHQNHLDKGANGQHYLLDYHPERQLFYYVISRNGEIIKGDESFPEIRENILQLINGWNPKNKEIRRETIKLGNGESISLLLSGKPVFQNNTRIGTIYTGINITTQIYIVKVLISVLCVISIIFIGLSVLLGYYMSGKAMVPIANAFQRQKEFVANASHELRTPLSIFQSSLEVIEADERDKLGEFSLQVFDDMKDELRRMTKLINDLLWLARSDANAIELTKEWFLLPPVIDELIRKCRSLAEQKHIKFVTNIQKDMAIYGDKERIIQLIFILLDNAVKYNTENGQIKIAVERDRKNVNIEISDTGIGIPVEQQALIFERFYRADPSRSRKQQGNGIGLSIAKWIVDAHGGTIRVQSEEGKGSRFIVTLPQPAN
>NC_014650.1|WP_049780667.1|2450308_2450530_+|hypothetical-protein
MCLIFRSPTAASDEKIETMDKKAEAMDDEKRKFAEMDERMQKMGGRLETKIDQRTIQPLRNKTDSLRIELSET
>NC_014650.1|WP_003251395.1|2450614_2451967_-|aspartate-aminotransferase-family-protein
MVQTYQNQQWLAKDRQYIWHSMKPYNPDATLVVTEAKGCWVTDHTGKKYLDAMAGLWCVNVGYGREELAEAAYEQLKKLAYFPLTQSHVPAIQLGEKLNELLGDEYVIFFSNSGSEANETAFKIARQYHQQKGEYNRYKIISRYRAYHGNSLGALAATGQAQRKYKYEPLAPGFIHVPPPDSYRDNEQAENPRDLRAVKAMDEVMTWELSETIAAVIMEPIITGGGVLMPPEGYMEAVKEVCEKHGALLIVDEVICGFGRTGKPFGFMNYGVKPDIITMAKGITSAYLPLSATAVRKEIYEAFKGTEEYDYFRHVNTFGGNPAACALALKNIEIMERENLFERSKEAGERLLNELKNKLQDHPYVGDVRGKGLLIGIELVADKNTKTPLDVSLVNKVIGICKENSLIIGKNGTTVAGYNNVLTLSPPLNIEDNDLSFLIKTLTDALWKIK
>NC_014650.1|WP_013401165.1|2452055_2453522_-|CoA-acylating-methylmalonate-semialdehyde-dehydrogenase
MAVIKNETMILKNFIYGKWVESSGTETLEVPNPATGEILARVPISTKEDVDRAVQAAKKAFETWKNTPVPKRARIMFAFHHLLNEHHEELATLVVQENGKAYKEAYGEIQRGIECVEFAAGAPTLMMGESLSGIAEGIDSEMFRYPLGVVAGITPFNFPMMVPLWMFPLAIACGNTFVLKPSERTPILANKLAELFTKAGAPEGVLNIVHGAHDVVNALIDHEDIQAISFVGSQPVAKYVYERAAARGKRVQALSGAKNHHIVMPDADIETAVQHVISSAFGSAGQRCMACSAVVVVGDNEQFVKRLKQKADELVIGNGMDPEVLLTPVIRQSHREKVLGYIQKGIEEGATLIRDGRKEIEEMPEGNFLGPTIFDYVTPDMTIAKEEIFAPVLSLLRANDLDEALEYIRKSRYGNGATIYTKDAKAVRKFREEADAGMLGINVGVPATMAFFPFSGWKDSFYGDLHVNGKDGVNFYTRKKMITSRFDF
>NC_014650.1|WP_083787428.1|2454285_2454600_+|DUF5082-domain-containing-protein
MSSLLESIEKEAKRRSYAAMIRCLPSYQGQVEEALDEFPHGSHSFYRANDEYAPHWQEESRGAYELVYWDLRQIEAQIYATADDLLHEISREIAPTQRKIEELQ
>NC_014650.1|WP_083787396.1|2454731_2455025_+|hypothetical-protein
MSVEVADENTYGLRFYDDINAYAKGRYLFETFTEQINRNNLALPPEWNQMTKIQQWKVKPGSIIIKGNAASQLQMGDRYIGGAKQWYITNLDDLTKP
>NC_014650.1|WP_013401167.1|2454985_2455273_+|hypothetical-protein
MVYNQPGRSDKTIEFLEMAEKIKIEVIKEITAHNNGKGKDGNITQLRKILDEVKKMSTILCPNNYTPSYPRIIVDSWDYNVFCKQKMQRIAVKNT
>NC_014650.1|WP_013399927.1|2455302_2456043_-|ATP-binding-protein
MTRDIKEICKALHLAYIADRFEEVPYETKEQFLRDVLALEVSSRQEAKRSKLIKKAKFRELKWLKDYEWSDHIHWPSTTTKEELCDLVFLERRQNVLLLGSPGTGKTHLATALGLKACEKGHEVRFFRVADLVAQLEEALKNGTLPRLKRQIETCELLILDELGYVPFQKQGSELLFHIIADCYERKSVIVTSNLEFGQWNRVFGDNRLTAALVDRLVHHAHIIAFTGESYRLRHALSSVKKISSN
>NC_014650.1|WP_013399926.1|2456014_2457544_-|IS21-family-transposase
MLAMPEIHYIKHLRENKDLSISEIARKTGLNWRTVKKYADGNIGGQKIMKKKRGMMYELGYGEIIDDWLEEDAKLPRKERRTNRTMFEQLQKEHGFPGSYRTVCAYIQERKPHLKAEKEKRYERLEHPPGEAQVDFGTMQVVKDGALEDKKLLILSFPHSNAGFAHPLPSENRECFLEGLKQLFHQAGGVPRRLRMDNLPAAVVTVGKGDNRQYTEAFLRFQAHYGFEVQPCNPASGHEKGNVERKVYYVRHRCFVPAPVVESDEQLTEWLRVKMIEDRSRLHYEKGVPIEELWKEDQKELKALPLDDLPIFSLDTVKVNKYGEITVDGEKWVIHQARVNQSLVVQKGWDRFICLSNQGEVVFEAPRPYMNQKQEIPWEEIFNDWEKKPRSVSYSRFFKYLPEKVQTYLTFRKEEVKQRVRGVRELLKSHTLKELDEWLNKEQRFDLAPHELKVLLEAKQQAYPEKWEETYTPSVFVNYETDLHLYDQRLCPSWEGGANRDDSGHQRDL
>NC_014650.1|WP_013401168.1|2459033_2460644_-|PucR-family-transcriptional-regulator
MKTSKLTVSDVLKRKHFEHIHIAAGHQGLNRTVKWVHVVEVAKISNLLKGKELILSTGVGWKENKSLFMSFVQQLIECDASGLCIEIGTYASSIPQEVIDLANECQFPIILFLKEVPFVEITQDIHAYLINQHYQIISNLESYSQELNKKLLSIGHYDEILKFLHHYLGHQVIFKINGKEVELVPKYVKRSDEEQQSFDSALYPQQKIASQSIQILGNEYAELSIVSIDKEINEFDLLILDRTATALAQHLLRDLYVEEKKRAQEHEWLKSWLEGEHTSEAIFDYLADHETELRFKGGFVSIFRFKSSKQYLNLDITYFKLLCRTIFEQQGFSTFPVDFRNSVIFIMVNKRDLKTWKHRMKMGIKYLLKSDFVNKKRVPKFLIGVGKFVENLSHMDKSYRTALETIKIQNQLGEKANSYFYEDLHIYRIISLIHKCSDLHEVVMEYLEPVIQYDKKYNGKLMETLKVYLECNGSKKETARKLFVVRQTLYHRIQKLEKLLGDDFMHPEKRLAIEFMIKAYEYFMPNNETQYVQNDQ
>NC_014650.1|WP_003251403.1|2461240_2461474_-|hypothetical-protein
MSYQEFLAEKEKIDYLIQQGYFIKNVRENLSGAFVEFELKRSDSSGKKDSTQVLHIQNADARKYFSSLLIRQMKQVL

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Crispr_ID: NC_014650_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014650_11

3144357-3144456

Orphan

Consensus_repeat	Method
AAATGAGGTGTTTGTCAAAGACA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014650_11

>merge|NC_014650|11|3144357-3144456|CRISPRCasFinder
AAATGAGGTGTTTGTCAAAGACACCATTATCGAAGCAACACCGTTATATGCGGTGAGAAAACGCGAAACTCCTTAACAAATGAGGTGTTTGTGAAAGACA

>NC_014650|11|11|3144357-3144456|CRISPRCasFinder
AAATGAGGTGTTTGTCAAAGACA	CCATTATCGAAGCAACACCGTTATATGCGGTGAGAAAACGCGAAACTCCTTAAC
AAATGAGGTGTTTGTGAAAGACA

Protein	Signature genes	Signature genes Name	Protein_function
NC_014650.1\|WP_013401506.1\|3136413_3137850_-\|protoporphyrinogen-oxidase	unknown	unknown	gnl\|CDD\|237009
NC_014650.1\|WP_003252557.1\|3148695_3149778_-\|3-phosphoserine/phosphohydroxythreonine-transaminase	unknown	unknown	gnl\|CDD\|235428
NC_014650.1\|WP_003252537.1\|3138814_3139852_-\|uroporphyrinogen-decarboxylase	unknown	unknown	gnl\|CDD\|234644
NC_014650.1\|WP_013401510.1\|3146333_3146513_-\|hypothetical-protein	unknown	unknown	unknown
NC_014650.1\|WP_003252552.1\|3147045_3147651_-\|HTH-type-transcriptional-regulator-Hpr	unknown	unknown	gnl\|CDD\|237501
NC_014650.1\|WP_003252549.1\|3144682_3145105_+\|HIT-family-protein	unknown	unknown	gnl\|CDD\|223611
NC_014650.1\|WP_013401513.1\|3150251_3151235_-\|3'-5'-exoribonuclease-YhaM	unknown	unknown	gnl\|CDD\|237394
NC_014650.1\|WP_013401509.1\|3142257_3143454_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|377581
NC_014650.1\|WP_003252556.1\|3148059_3148584_-\|tryptophan-transporter	unknown	unknown	gnl\|CDD\|293704
NC_014650.1\|WP_071880410.1\|3146174_3146264_+\|YjcZ-family-sporulation-protein	unknown	unknown	unknown
NC_014650.1\|WP_013401507.1\|3140169_3141570_-\|hypothetical-protein	unknown	unknown	unknown
NC_014650.1\|WP_003252547.1\|3143450_3144188_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NC_014650.1\|WP_013401505.1\|3135755_3136328_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_014650.1\|WP_013401504.1\|3133284_3135687_-\|YhgE/Pip-domain-containing-protein	unknown	unknown	gnl\|CDD\|224428
NC_014650.1\|WP_013401503.1\|3133019_3133157_+\|YhfH-family-protein	unknown	unknown	gnl\|CDD\|379490
NC_014650.1\|WP_013401508.1\|3141741_3142245_-\|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl\|CDD\|225209
NC_014650.1\|WP_013401512.1\|3149886_3150072_-\|sporulation-YhaL-family-protein	unknown	unknown	gnl\|CDD\|290852
NC_014650.1\|WP_003252550.1\|3145146_3145983_-\|peptidylprolyl-isomerase	unknown	unknown	gnl\|CDD\|179537
NC_014650.1\|WP_003252535.1\|3137865_3138801_-\|ferrochelatase	unknown	unknown	gnl\|CDD\|183526
NC_014650.1\|WP_003252551.1\|3146711_3147053_+\|YhaI-family-protein	unknown	unknown	gnl\|CDD\|370213

Protein	Function_ID	Function_description	E-value
NC_014650.1\|WP_013401506.1\|3136413_3137850_-\|protoporphyrinogen-oxidase	gnl\|CDD\|237009	PRK11883, PRK11883, protoporphyrinogen oxidase; Reviewed.	0
NC_014650.1\|WP_003252557.1\|3148695_3149778_-\|3-phosphoserine/phosphohydroxythreonine-transaminase	gnl\|CDD\|235428	PRK05355, PRK05355, 3-phosphoserine/phosphohydroxythreonine transaminase.	0
NC_014650.1\|WP_003252537.1\|3138814_3139852_-\|uroporphyrinogen-decarboxylase	gnl\|CDD\|234644	PRK00115, hemE, uroporphyrinogen decarboxylase; Validated.	0
NC_014650.1\|WP_003252552.1\|3147045_3147651_-\|HTH-type-transcriptional-regulator-Hpr	gnl\|CDD\|237501	PRK13777, PRK13777, HTH-type transcriptional regulator Hpr.	1.68357e-127
NC_014650.1\|WP_003252549.1\|3144682_3145105_+\|HIT-family-protein	gnl\|CDD\|223611	COG0537, Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only].	1.7969e-57
NC_014650.1\|WP_013401513.1\|3150251_3151235_-\|3'-5'-exoribonuclease-YhaM	gnl\|CDD\|237394	PRK13480, PRK13480, 3'-5' exoribonuclease YhaM; Provisional.	0
NC_014650.1\|WP_013401509.1\|3142257_3143454_-\|ABC-transporter-permease	gnl\|CDD\|377581	pfam05975, EcsB, Bacterial ABC transporter protein EcsB. This family consists of several bacterial ABC transporter proteins which are homologous to the EcsB protein of Bacillus subtilis. EcsB is thought to encode a hydrophobic protein with six membrane-spanning helices in a pattern found in other hydrophobic components of ABC transporters.	1.4943e-111
NC_014650.1\|WP_003252556.1\|3148059_3148584_-\|tryptophan-transporter	gnl\|CDD\|293704	pfam17099, TrpP, Tryptophan transporter TrpP. TrpP is a bacterial transmembrane protein that is probably involved in tryptophan uptake. Its expression is regulated by tryptophan-activated RNA-binding regulatory protein (TRAP).	1.07855e-40
NC_014650.1\|WP_003252547.1\|3143450_3144188_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	4.99434e-81
NC_014650.1\|WP_013401505.1\|3135755_3136328_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.70149e-15
NC_014650.1\|WP_013401504.1\|3133284_3135687_-\|YhgE/Pip-domain-containing-protein	gnl\|CDD\|224428	COG1511, COG1511, Predicted membrane protein [Function unknown].	1.16036e-162
NC_014650.1\|WP_013401503.1\|3133019_3133157_+\|YhfH-family-protein	gnl\|CDD\|379490	pfam14149, YhfH, YhfH-like protein. The YhfH-like protein family includes the B. subtilis YhfH protein, which is functionally uncharacterized. Its expression is repressed by the Spx paralogue MgsR, which regulates genes involved in stress response. This family of proteins is found in bacteria. Proteins in this family are typically between 42 and 53 amino acids in length.	3.88651e-14
NC_014650.1\|WP_013401508.1\|3141741_3142245_-\|antibiotic-biosynthesis-monooxygenase	gnl\|CDD\|225209	COG2329, COG2329, Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only].	1.20439e-16
NC_014650.1\|WP_013401512.1\|3149886_3150072_-\|sporulation-YhaL-family-protein	gnl\|CDD\|290852	pfam14147, Spore_YhaL, Sporulation protein YhaL. This family of proteins is involved in sporulation. In B. subtilis its expression is regulated by the early mother-cell-specific transcription factor sigma-E.	7.2104e-19
NC_014650.1\|WP_003252550.1\|3145146_3145983_-\|peptidylprolyl-isomerase	gnl\|CDD\|179537	PRK03095, prsA, peptidylprolyl isomerase PrsA.	1.33826e-66
NC_014650.1\|WP_003252535.1\|3137865_3138801_-\|ferrochelatase	gnl\|CDD\|183526	PRK12435, PRK12435, ferrochelatase; Provisional.	0
NC_014650.1\|WP_003252551.1\|3146711_3147053_+\|YhaI-family-protein	gnl\|CDD\|370213	pfam08963, DUF1878, Protein of unknown function (DUF1878). This domain is found in a set of hypothetical bacterial proteins.	3.44416e-48

>NC_014650.1|WP_003252547.1|3143450_3144188_-|ABC-transporter-ATP-binding-protein
MALLEVHHLYGGYTKQNVLEDVSFTVDRGEIVGLIGLNGAGKSTTIKHIIGLMEPRKGTITINGTMFSEQPDAYRSQFTYIPETPILYEELTLEEHLQLTAMAYGLEKSEYERRLPPLLKEFRMEKRLKWFPAHFSKGMKQKVMIMCAFLVEPALYIIDEPFLGLDPLGIHSLLEQMQRMKKKGAGILMSTHILATAEKYCDSFVILHNGKVRAKGTMAELREQFSSPAATLDELYIELTKEDSV
>NC_014650.1|WP_013401509.1|3142257_3143454_-|ABC-transporter-permease
MINGKRLWNDRLYQEARKMRRYLRYMLNDHLLFILLIGIGLGAVAYRHWVQTLPPHFPYPIVAALFFSFMLTFGSLRTLFQEADIVFLLPAETKLGPYIQRAFLLSFLLQAYGLLLIWLAVAPLHQKFSDVSIWRLFLVLLVLKGWNLFISWKGNYFIESLTHRLSALSRFGLNAAFVYFLLADASFFFLLAICALMAGITFYVVQATKRKGWKWERIIEQEAKAVRAFYRIANLFTDVPQWKEEAKRRRWLDFLISMIPYQQKNTFLYLYVRTFLRSGGYFSLYVRLIAIGLLLLYIVPTEYGKIAASLFFLYITGFQLFALIDHHRTNLLIRLYPLPDDVRKQAVCRLLFFLLIVQNSVFSLFLFLLDAGVIWMVSWSAGAVFSYWLLFHYLKRRK
>NC_014650.1|WP_013401508.1|3141741_3142245_-|antibiotic-biosynthesis-monooxygenase
MKNMYITTGTTDYLQKVKDMHKNETMLLLERKEDAVLLHETDGETVFKEPRCYEVIDAAGELGGAFVVCNNIPVTDEGRPLFEHRFQQRARLIENEPGFVAIRVLRPLSNDTYVIMTLWEAKKYFEQWQRSNAFAKAHAQRKEEQKPSRQIFPRPSYVTTYSVVQER
>NC_014650.1|WP_013401507.1|3140169_3141570_-|hypothetical-protein
MGVELTVLHWIYLAFIVLIIGFMIARKDTSLVCIVGIFLLSVAATYSLSAAISGVFHSFIYAMTELLPTILVISIIVAMSKAMTATGINDVMVSPFTRFIRTPGWAYWTIGILMMVISCFFWPSPAVALMGAVLLPVAIRVGLPPLGAAMTMNLFGHGVALSGDFVIQGAPKLTADAAGLPVSEVIAASVPLVLVMGATTTLTAFLLLRRDMKRGYFANEANEVAVTADAALEKTERLLSSQVKNMMAAIIPAMFVFDVITMFYLHLQGGEATALIGGTAIFILILISIFAHKKESFGEITNYLVEGFQFGIKVFAPVVPIAAFFYLGDAGFAKIIGEHLPKLSQGIVNDLGVALAHIVPLNNGIGAVTLTVVGAITGLDGSGFSGISLAGSVAHLFATAIGGGAATLTALGQIAAIWVGGGTLVPWALIPAAAICGVDPFELARRNLVPVTVGIVITTIVAMFLM
>NC_014650.1|WP_003252537.1|3138814_3139852_-|uroporphyrinogen-decarboxylase
MSKWMNDTFLRACRGEKTDYVPVWYMRQAGRSQPEYRALKEKYSLFEITHQPELCAYVTRLPVEQYNVDAAILYKDIMSPLPAIGVDVEIKAGVGPVIANPIRSLADVERLGEIHPEEDVPYVLETIKLLTTEQLNVPLIGFAGAPFTLASYMIEGGPSKNYNKTKAFMYAEPKAWFALMDKLADMTIRYVKAQIRAGADAIQIFDSWVGAVSVDDYRTFIKPTMARIFAALREENVPLIMFGVGASHLAKEWNDLPLDVIGLDWRLSLREARESGITKALQGNLDPAVLLAPWEVIEKRVKQILDEGMERPGYVFNLGHGIFPEIRPETLKRLTAFIHEYTSRK
>NC_014650.1|WP_003252535.1|3137865_3138801_-|ferrochelatase
MAKKKMGLLVMAYGTPYKEEDIERYYTHIRHGRKPSPELLEDLKQRYKAIGGISPLAQITLDQAKQLEKRLNSVQDDMEFQMYLGLKHIEPFVEDAVRQMHEDGIEEAVGIVLAPHFSTFSIQSYNERAKAEAEKLGGPVIYTIDSWYDEPKFIDYWVEKVKEVFASMSEEERDKAVLIVSAHSLPEKIIAAGDPYPQQLAETAKLIAEKAGVKHYAVGWQSAGNTPEPWLGPDVQDLTRQLHQEHGYTSFVYVPAGFVADHLEVLYDNDIECKQVTEEIGANYYRPEMPNTNAKFIDALATVVLKRTKLL
>NC_014650.1|WP_013401506.1|3136413_3137850_-|protoporphyrinogen-oxidase
MNDEKYTVVIIGGGITGITAAYYLQKAVKERQLPIECKLVEATHRLGGKVQTVVRDGFVIERGPDSFLARKTSAFRLVREVGLENEIVHNATGKSYILVNGKLYPIPGGAIMGIPTQIGPFITTRLFSPLGKLRAAFDFILPPTKAEGDLSLGQFFRRRLGDEVVDNLIEPLLSGIYAGDIDQMSLMATFPQFFQIEQKYGSLVLGAKRTAPKAQKERKGAFQTLKTGLQSLVDEVEKRMEQGSVIKGVRVERVWREGTGYRLRLSNGDIWKADSIIVAAPHSSVPAMFADYPFFEPFQSIPSTSVATVALAFPESAIEQDIDGTGFVVSRRNDYTITACTWTHKKWPHTAPDGKALLRCYVGRPGDEEIVEQSDDEIVRVVMDDLSKIMRISGRPELIAISRWKEAMPQYNVGHKERLAKIKTHMDAELPGVFLAGSSYEGLGLPDCIDQGENAVKKVLDYLQTAPRKLAEVNSKMS
>NC_014650.1|WP_013401505.1|3135755_3136328_-|TetR/AcrR-family-transcriptional-regulator
MSIDRKRQIIEAAAKSFSLFGYKATTMEQIAKLANVGKGTIYTFFKNKEDLLDAIVSSLILEIIEEAEQAMDPDRPFSENAHRALYRILEFRQQHQLTAKLLQEVRNLGTPAVQEVMKKLDLAIIDYIRKKIDIAIKKGEIRDCDAEITAFLMLKTYIALIVDWEKDHEPLTKEEIAQLFELYFLKGLSK
>NC_014650.1|WP_013401504.1|3133284_3135687_-|YhgE/Pip-domain-containing-protein
MRGFSLLWKEAEAIFRNRKVLISIIAVICIPLLYSGMFLWAFWDPYAHLDQLPVAVVNNDKGATMNGEKLEIGDKLVEKLKENKKFDWHFVSEKEAEKGLQHQTYYMAIEIPDDFSKNATTLQTEHPKPMKLIYKPNEAFNFLSAQIGDSAVEKIKEEISNTVTETYVEAMFDNIREMANGLNQASDGAKQLHDGIKKAKDGGAALQSGLHSAKEGSGKLQQGAHAAKNGADELYKNLKLLAEKSLMFENGMQSASDGADRLNEGLHQLQNGFAKMQEGHSQLLAGAKQVENGAKQLSGGLHQSLDGMEQMKGNIPQLTKGTQDLQNGAQQLSASMEQWQQGAEKTNKGALQVSQGLEKAVEQLDALAAQATDPNEKVLLQTLKQQLLPLSEGSKQVAQGTEQLANSASQLKTGADQLAEGASRLHNGQLALSKGVETLLAGQQRLANGADALVAGQSKVVQGLTTFGEKLQEGKNGVQQLASGSNQLSSGLRQLAQGSSQFKDGTNQLADGSGKLASGINDLENGATALSNGMNQLANGSDQLVNGMKKLDDGSNELADKLTDGAKKASDVKANDDVYKMFADPVKKNNEKMHHVPNYGTGFTPYFLSLGLFVGALLLSIVFPLREPVGVPKSGFSWFIGKFGVLLVIGVIQSLLVDALLLGALDIHVKSVPRFVLFTIITSITFITLIQFLVTTLGDPGRFIGIIILILQLTTSAGTFPLELIPSELQHFNAWLPMTYSVHGFKAVISSGDFAFMWHNAAILALFIAVFITATISYFLVQHKRKFYTVAQQMNKASEA
>NC_014650.1|WP_013401503.1|3133019_3133157_+|YhfH-family-protein
MLGKVLEFFKNLPPKKCVQCGKEIEEQHECYGNTCEDCLGAAYHQ
>NC_014650.1|WP_003252549.1|3144682_3145105_+|HIT-family-protein
MSECIFCKIVNGDIPAAKVYEDENVLAFLDISQVTKGHTLVIPKVHKANIFELTPDVASHVFTAIPKIANAIKKQFSPVGLNLLNNNGEQAGQTVFHYHVHLIPRYGKGDGFGAVWKSHASDYTFDDLQDIAATIQKGLQ
>NC_014650.1|WP_003252550.1|3145146_3145983_-|peptidylprolyl-isomerase
MKKWMIAAAVASVFALSACSNGDSEVIVKTKDGDITKEEFYNEMKARVGKEVIRDLVHEKVLSKKYKVTDKEIDKEIENLKDMYGVQYDLVVQQNGEKAIRDMVKLDLLRQKAAMEDIKVTDKELKDYYENYKPKIRASHILVKDEKTAKEIKAKLDKGEDFAKLAKQYSQDPGSASNGGDLGWFGQGKMVKEFEDAAYKLKVGEISDPVKTEYGYHIIKVTDKEEKKPFNEMKEEIEFEVKRSKLDPAKMQAKVEKLVKDAKADIKDKDLQDALKQQ
>NC_014650.1|WP_071880410.1|3146174_3146264_+|YjcZ-family-sporulation-protein
MSGAPYAGGFALIVVLFILLIIVGCACLF
>NC_014650.1|WP_013401510.1|3146333_3146513_-|hypothetical-protein
MTVYFIPLAVIILFLINQLTSRLCAQREIPEEKQPGVFRTINVLITILLITSYFEVLFT
>NC_014650.1|WP_003252551.1|3146711_3147053_+|YhaI-family-protein
METLEERIAKLEFHRSLLMEMVDKTKKPFYYLVIQANLTKEEVDEVLALCQQLSEEYEKQKAEGLTIFTPLLLHFAGMLHPSLPLEQTIDALLQQQMFVPLMTELKKLIQTVS
>NC_014650.1|WP_003252552.1|3147045_3147651_-|HTH-type-transcriptional-regulator-Hpr
MKTTEQNYSIKEALLFSQRIAQLSKALWKSIEKDWQQWIKPFDLNINEHHILWIAYHFKGASISEIAKFGVMHVSTAFNFSKKLEERGLLSFSKKQDDKRNTYIELTEKGEEVLLKLMESYDPTKNAVFNGALPLRDLYGKFPEILEMMCIIRNIYGDDFMEIFERAFENIKSDFVEQDGKLVKRNARPQEKEKELTSQPS
>NC_014650.1|WP_003252556.1|3148059_3148584_-|tryptophan-transporter
MNTRVLVSLALLVGIGAVLHAVIPGIFFGMKPDMMLTMMFLAILLFPNVKTAGLVGIVTGVISAMTTGFPGGQVPNIIDKIITAFVFFAFVCLLKKYGQTVVSAAILTAVGTVISGTIFLTAALLFAGLPGGATFSALFLTVVLPATAINTIVMVIIYPIVSAIFKRMNITVHV
>NC_014650.1|WP_003252557.1|3148695_3149778_-|3-phosphoserine/phosphohydroxythreonine-transaminase
MKRAYNFNAGPSALPLPVLKRAQEELLNFQNTGMSVMELSHRSKEYDAVHNSAKQRLKKLMNIPDTHDILFLQGGASLQFSMVPMNLLGKDKVANYVLTGSWSEKALKEAKKIGKTHIAASSKEANYTYIPRLEDIQLSENAAYLHITSNNTIFGTQWREFPDLPVDLVADMSSDILSREINVGQFALIYAGAQKNLGPSGVTVVIIRNDLLERIPDNLPTMLDYRTHSSSNSLYNTPPTFAIYMLSLVLEWVEEQGGVKAIEARNKEKAAVVYEAIDASNGFYAPHAEKDSRSLMNVTFTLPNEELTKQFLAEAKEKGFVGLAGHRSVGGCRASIYNAVPLEACEALAGFMNDFYRRFS
>NC_014650.1|WP_013401512.1|3149886_3150072_-|sporulation-YhaL-family-protein
MLSMPWWIYLVVAGIIFSGYMTVRTAAREREIDEAMIEKEGEIYMERIREERKRRQQAKSL
>NC_014650.1|WP_013401513.1|3150251_3151235_-|3'-5'-exoribonuclease-YhaM
MAKGIIHYDVGEQVDVYLLIKSVTKGIASNGKPFLTLILQDKTGDIEAKLWDVSPEDESVYVPESIVKVFGDIHNYRGKTQLKIRSIRPARAGDDVRVSDFLETAPMKREEMMEKITQYILDMENPNIQRITRYLLKKYEQKFFDYPAATKNHHEFISGLAYHVVSMLELAKALVNLYPSLNKDLLYAGVILHDLGKVIELSGPVSASYTLEGNLLGHISIMVSEISKAAEHLGISGEEVVVLQHMVLSHHGKTEWGSPKPPMVKEAEILHYIDNLDAKLNMIDRALEKVKPGEFTERIFALENRSFYKPMFLSAPAVSKQEKRGIS

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Crispr_ID: NC_014650_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014650_12

3431432-3432954

TypeI-B

Consensus_repeat	Method
GTTTCAATTCCTCATAGGTAAGATACAAAC	CRISPRCasFinder
GTTTCAATTCCTCATAGGTAAGATACAAAC	CRT
GTTTGTATCTTACCTATGAGGAATTGAAAC	PILER-CR

22 spacers

cas6,cas2,cas1,cas4,cas3,cas5,cas7b,cas8b1

The CRISPR arrays of NC_014650_12

>merge|NC_014650|12|3431432-3432954|CRISPRCasFinder,CRT,PILER-CR
GGGGACAATCTTCATAGCTAAGATAAAAACAGGCAAAATCGGTCCATAAGATACAAACAGGCACGCGACACGAAAGCTGTCAAGTCGCAGACCACGTTTCAATTCCTCATAGGTAAGATACAAACTGTAGATGATTCAATAATTAGAAATCTGTTTAATGGATTTCAATTCCTCATAGGTAAGATACAAACTCACATCAGAAAGGAAACGGACAACATATGAAAGAAAGTTTCAATTCCTCATAGGTAAGATACAAACGAATTTGGAAAATCAAGAGCGCAATATTCAGCAGAGTTTCAATTCCTCATAGGTAAGATACAAACAAACAACCGCAAAGATTTTCTTTCCGTATTTCCAGAGTTTCAATTCCTCATAGGTAAGATACAAACTCCAACGTCTTGGGCAGGGAAAGAATTGCATTTTCGAGGTTTCAATTCCTCATAGGTAAGATACAAACGGCGAAAAAGGTAGAGCTTCAGAAGAAAAAAGAATGTTTCAATTCCTCATAGGTAAGATACAAACGCTCGACCGCAACGGCGCCCAGGCGGACCACTTGCGGGTTTCAATTCCTCATAGGTAAGATACAAACATTACGTCGTCAATGACCCGTTGGAGTACGCAGAGTTGTTTCAATTCCTCATAGGTAAGATACAAACCGCCACCCCGAAAACAAAGGACTCATCGTCCGGTGGGAGTTTCAATTCCTCATAGGTAAGATACAAACAAGCAAGACGTACTATTCAACGCGCGTTGAATTTGTGTTTCAATTCCTCATAGGTAAGATACAAACCACCTTTAAACTTCATGTAGGCGTGGGCAAATTGTTCGTTTCAATTCCTCATAGGTAAGATACAAACGTTCATCCAGCTGGCGTTGCATATCAAAGAGAACCGCGTTTCAATTCCTCATAGGTAAGATACAAACATCGTATCGAAGCGTGAAAATGTAATCTCCATCTTTCGGTTTCAATTCCTCATAGGTAAGATACAAACTTTCCGTGTATCGCGTTATTTACATATGCACGAAACTGTTTCAATTCCTCATAGGTAAGATACAAACGAGTAGACGAAAGGAGGAATATGAATGGTGAAATAGTTTCAATTCCTCATAGGTAAGATACAAACAAAAAATCTTTGCTTTCGAAAGCAAAAAATTTTGGCCGGTTTCAATTCCTCATAGGTAAGATACAAACATGGTGGAGTGCCAGTATTAAAGCAGATACTACAATGTTTCAATTCCTCATAGGTAAGATACAAACCTTCTTGAGAACCACCAAAAATAGCTACTGTTTTCAGTTTCAATTCCTCATAGGTAAGATACAAACGTGTGTCCAACTCGTTCTGTTGTTTGGCTCCAGCATGTTTCAATTCCTCATAGGTAAGATACAAACTCGTATATGCTGGCTTATCGAAAGAGAGTCTTCGATAAGTTTCAATTCCTCATAGGTAAGATACAAACTTTCCGCGTCACCTTCATCGAAATAACTCGGCTCGGTTTCAATTCCTCATAGGTAAGATACAAAC

>NC_014650|12|12|3431432-3432954|CRISPRCasFinder
GGGGACAATCTTCATAGCTAAGATAAAAAC	AGGCAAAATCGGTCCATAAGATACAAACAGGCACGCGACACGAAAGCTGTCAAGTCGCAGACCAC
GTTTCAATTCCTCATAGGTAAGATACAAAC	TGTAGATGATTCAATAATTAGAAATCTGTTTAATGG
ATTTCAATTCCTCATAGGTAAGATACAAAC	TCACATCAGAAAGGAAACGGACAACATATGAAAGAAA
GTTTCAATTCCTCATAGGTAAGATACAAAC	GAATTTGGAAAATCAAGAGCGCAATATTCAGCAGA
GTTTCAATTCCTCATAGGTAAGATACAAAC	AAACAACCGCAAAGATTTTCTTTCCGTATTTCCAGA
GTTTCAATTCCTCATAGGTAAGATACAAAC	TCCAACGTCTTGGGCAGGGAAAGAATTGCATTTTCGAG
GTTTCAATTCCTCATAGGTAAGATACAAAC	GGCGAAAAAGGTAGAGCTTCAGAAGAAAAAAGAAT
GTTTCAATTCCTCATAGGTAAGATACAAAC	GCTCGACCGCAACGGCGCCCAGGCGGACCACTTGCGG
GTTTCAATTCCTCATAGGTAAGATACAAAC	ATTACGTCGTCAATGACCCGTTGGAGTACGCAGAGTT
GTTTCAATTCCTCATAGGTAAGATACAAAC	CGCCACCCCGAAAACAAAGGACTCATCGTCCGGTGGGA
GTTTCAATTCCTCATAGGTAAGATACAAAC	AAGCAAGACGTACTATTCAACGCGCGTTGAATTTGT
GTTTCAATTCCTCATAGGTAAGATACAAAC	CACCTTTAAACTTCATGTAGGCGTGGGCAAATTGTTC
GTTTCAATTCCTCATAGGTAAGATACAAAC	GTTCATCCAGCTGGCGTTGCATATCAAAGAGAACCGC
GTTTCAATTCCTCATAGGTAAGATACAAAC	ATCGTATCGAAGCGTGAAAATGTAATCTCCATCTTTCG
GTTTCAATTCCTCATAGGTAAGATACAAAC	TTTCCGTGTATCGCGTTATTTACATATGCACGAAACT
GTTTCAATTCCTCATAGGTAAGATACAAAC	GAGTAGACGAAAGGAGGAATATGAATGGTGAAATA
GTTTCAATTCCTCATAGGTAAGATACAAAC	AAAAAATCTTTGCTTTCGAAAGCAAAAAATTTTGGCCG
GTTTCAATTCCTCATAGGTAAGATACAAAC	ATGGTGGAGTGCCAGTATTAAAGCAGATACTACAAT
GTTTCAATTCCTCATAGGTAAGATACAAAC	CTTCTTGAGAACCACCAAAAATAGCTACTGTTTTCA
GTTTCAATTCCTCATAGGTAAGATACAAAC	GTGTGTCCAACTCGTTCTGTTGTTTGGCTCCAGCAT
GTTTCAATTCCTCATAGGTAAGATACAAAC	TCGTATATGCTGGCTTATCGAAAGAGAGTCTTCGATAA
GTTTCAATTCCTCATAGGTAAGATACAAAC	TTTCCGCGTCACCTTCATCGAAATAACTCGGCTCG
GTTTCAATTCCTCATAGGTAAGATACAAAC

>NC_014650|12|5|3431460-3432954|CRT
ACAGGCAAAATCGGTCCATAAGATACAAAC	AGGCACGCGACACGAAAGCTGTCAAGTCGCAGACCAC
GTTTCAATTCCTCATAGGTAAGATACAAAC	TGTAGATGATTCAATAATTAGAAATCTGTTTAATGG
ATTTCAATTCCTCATAGGTAAGATACAAAC	TCACATCAGAAAGGAAACGGACAACATATGAAAGAAA
GTTTCAATTCCTCATAGGTAAGATACAAAC	GAATTTGGAAAATCAAGAGCGCAATATTCAGCAGA
GTTTCAATTCCTCATAGGTAAGATACAAAC	AAACAACCGCAAAGATTTTCTTTCCGTATTTCCAGA
GTTTCAATTCCTCATAGGTAAGATACAAAC	TCCAACGTCTTGGGCAGGGAAAGAATTGCATTTTCGAG
GTTTCAATTCCTCATAGGTAAGATACAAAC	GGCGAAAAAGGTAGAGCTTCAGAAGAAAAAAGAAT
GTTTCAATTCCTCATAGGTAAGATACAAAC	GCTCGACCGCAACGGCGCCCAGGCGGACCACTTGCGG
GTTTCAATTCCTCATAGGTAAGATACAAAC	ATTACGTCGTCAATGACCCGTTGGAGTACGCAGAGTT
GTTTCAATTCCTCATAGGTAAGATACAAAC	CGCCACCCCGAAAACAAAGGACTCATCGTCCGGTGGGA
GTTTCAATTCCTCATAGGTAAGATACAAAC	AAGCAAGACGTACTATTCAACGCGCGTTGAATTTGT
GTTTCAATTCCTCATAGGTAAGATACAAAC	CACCTTTAAACTTCATGTAGGCGTGGGCAAATTGTTC
GTTTCAATTCCTCATAGGTAAGATACAAAC	GTTCATCCAGCTGGCGTTGCATATCAAAGAGAACCGC
GTTTCAATTCCTCATAGGTAAGATACAAAC	ATCGTATCGAAGCGTGAAAATGTAATCTCCATCTTTCG
GTTTCAATTCCTCATAGGTAAGATACAAAC	TTTCCGTGTATCGCGTTATTTACATATGCACGAAACT
GTTTCAATTCCTCATAGGTAAGATACAAAC	GAGTAGACGAAAGGAGGAATATGAATGGTGAAATA
GTTTCAATTCCTCATAGGTAAGATACAAAC	AAAAAATCTTTGCTTTCGAAAGCAAAAAATTTTGGCCG
GTTTCAATTCCTCATAGGTAAGATACAAAC	ATGGTGGAGTGCCAGTATTAAAGCAGATACTACAAT
GTTTCAATTCCTCATAGGTAAGATACAAAC	CTTCTTGAGAACCACCAAAAATAGCTACTGTTTTCA
GTTTCAATTCCTCATAGGTAAGATACAAAC	GTGTGTCCAACTCGTTCTGTTGTTTGGCTCCAGCAT
GTTTCAATTCCTCATAGGTAAGATACAAAC	TCGTATATGCTGGCTTATCGAAAGAGAGTCTTCGATAA
GTTTCAATTCCTCATAGGTAAGATACAAAC	TTTCCGCGTCACCTTCATCGAAATAACTCGGCTCG
GTTTCAATTCCTCATAGGTAAGATACAAAC

>NC_014650|12|5|3431527-3432954|PILER-CR
GTTTCAATTCCTCATAGGTAAGATACAAAC	TGTAGATGATTCAATAATTAGAAATCTGTTTAATGG
ATTTCAATTCCTCATAGGTAAGATACAAAC	TCACATCAGAAAGGAAACGGACAACATATGAAAGAAA
GTTTCAATTCCTCATAGGTAAGATACAAAC	GAATTTGGAAAATCAAGAGCGCAATATTCAGCAGA
GTTTCAATTCCTCATAGGTAAGATACAAAC	AAACAACCGCAAAGATTTTCTTTCCGTATTTCCAGA
GTTTCAATTCCTCATAGGTAAGATACAAAC	TCCAACGTCTTGGGCAGGGAAAGAATTGCATTTTCGAG
GTTTCAATTCCTCATAGGTAAGATACAAAC	GGCGAAAAAGGTAGAGCTTCAGAAGAAAAAAGAAT
GTTTCAATTCCTCATAGGTAAGATACAAAC	GCTCGACCGCAACGGCGCCCAGGCGGACCACTTGCGG
GTTTCAATTCCTCATAGGTAAGATACAAAC	ATTACGTCGTCAATGACCCGTTGGAGTACGCAGAGTT
GTTTCAATTCCTCATAGGTAAGATACAAAC	CGCCACCCCGAAAACAAAGGACTCATCGTCCGGTGGGA
GTTTCAATTCCTCATAGGTAAGATACAAAC	AAGCAAGACGTACTATTCAACGCGCGTTGAATTTGT
GTTTCAATTCCTCATAGGTAAGATACAAAC	CACCTTTAAACTTCATGTAGGCGTGGGCAAATTGTTC
GTTTCAATTCCTCATAGGTAAGATACAAAC	GTTCATCCAGCTGGCGTTGCATATCAAAGAGAACCGC
GTTTCAATTCCTCATAGGTAAGATACAAAC	ATCGTATCGAAGCGTGAAAATGTAATCTCCATCTTTCG
GTTTCAATTCCTCATAGGTAAGATACAAAC	TTTCCGTGTATCGCGTTATTTACATATGCACGAAACT
GTTTCAATTCCTCATAGGTAAGATACAAAC	GAGTAGACGAAAGGAGGAATATGAATGGTGAAATA
GTTTCAATTCCTCATAGGTAAGATACAAAC	AAAAAATCTTTGCTTTCGAAAGCAAAAAATTTTGGCCG
GTTTCAATTCCTCATAGGTAAGATACAAAC	ATGGTGGAGTGCCAGTATTAAAGCAGATACTACAAT
GTTTCAATTCCTCATAGGTAAGATACAAAC	CTTCTTGAGAACCACCAAAAATAGCTACTGTTTTCA
GTTTCAATTCCTCATAGGTAAGATACAAAC	GTGTGTCCAACTCGTTCTGTTGTTTGGCTCCAGCAT
GTTTCAATTCCTCATAGGTAAGATACAAAC	TCGTATATGCTGGCTTATCGAAAGAGAGTCTTCGATAA
GTTTCAATTCCTCATAGGTAAGATACAAAC	TTTCCGCGTCACCTTCATCGAAATAACTCGGCTCG
GTTTCAATTCCTCATAGGTAAGATACAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_014650.1\|WP_013401702.1\|3444462_3445740_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340874
NC_014650.1\|WP_003253139.1\|3422504_3423296_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224097
NC_014650.1\|WP_003253159.1\|3434157_3434421_-\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NC_014650.1\|WP_013401689.1\|3420617_3421691_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270381
NC_014650.1\|WP_003253137.1\|3421687_3422494_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224098
NC_014650.1\|WP_003253157.1\|3433136_3433883_-\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	gnl\|CDD\|224499
NC_014650.1\|WP_003253141.1\|3423285_3424359_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226361
NC_014650.1\|WP_013401688.1\|3419487_3420594_-\|peptidase-M50	unknown	unknown	gnl\|CDD\|100081
NC_014650.1\|WP_083787410.1\|3425542_3426610_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224428
NC_014650.1\|WP_013401697.1\|3435440_3435938_-\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
NC_014650.1\|WP_013401698.1\|3435937_3438421_-\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|224124
NC_014650.1\|WP_013401695.1\|3430325_3431225_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381364
NC_014650.1\|WP_003253168.1\|3442782_3443538_-\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NC_014650.1\|WP_013401700.1\|3439214_3440150_-\|type-I-B-CRISPR-associated-protein-Cas7/Csh2	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	gnl\|CDD\|377458
NC_014650.1\|WP_013401693.1\|3427076_3429161_-\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|223964
NC_014650.1\|WP_013401687.1\|3418140_3419418_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340913
NC_014650.1\|WP_013401696.1\|3434430_3435438_-\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|274695
NC_014650.1\|WP_013401701.1\|3440312_3442283_-\|TIGR02556-family-CRISPR-associated-protein	cas8b1	pfam09484_cas8b1_CAS-I-B	gnl\|CDD\|187861
NC_014650.1\|WP_013401699.1\|3438465_3439200_-\|type-I-B-CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	gnl\|CDD\|187823
NC_014650.1\|WP_013401694.1\|3429445_3430123_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|273017

Protein	Function_ID	Function_description	E-value
NC_014650.1\|WP_013401702.1\|3444462_3445740_-\|MFS-transporter	gnl\|CDD\|340874	cd17316, MFS_SV2_like, Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily. This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.32531e-31
NC_014650.1\|WP_003253139.1\|3422504_3423296_-\|ABC-transporter-permease	gnl\|CDD\|224097	COG1176, PotB, ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism].	4.88049e-78
NC_014650.1\|WP_003253159.1\|3434157_3434421_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	6.70309e-30
NC_014650.1\|WP_013401689.1\|3420617_3421691_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270381	cd13663, PBP2_PotD_PotF_like_2, The periplasmic substrate-binding component of an uncharacterized active transport system closely related to spermidine and putrescine transporters; contains the type 2 periplasmic binding fold. This group represents the periplasmic substrate-binding domain that serves as a primary polyamine receptor of an uncharacterized ABC-type transport system from gram-negative bacteria. Polyamine transport plays an essential role in the regulation of intracellular polyamine levels which are known to be elevated in rapidly proliferating cells and tumors. Natural polyamines are putrescine, spermindine, and spermine. They are polycations that play multiple roles in cell growth, survival and proliferation, as well as plant stress and disease resistance. They can interact with negatively charged molecules, such as nucleic acids, to modulate their functions. Members of this family belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	8.78223e-154
NC_014650.1\|WP_003253137.1\|3421687_3422494_-\|ABC-transporter-permease	gnl\|CDD\|224098	COG1177, PotC, ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism].	1.30318e-79
NC_014650.1\|WP_003253157.1\|3433136_3433883_-\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|224499	COG1583, COG1583, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	3.95694e-26
NC_014650.1\|WP_003253141.1\|3423285_3424359_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	3.65673e-168
NC_014650.1\|WP_013401688.1\|3419487_3420594_-\|peptidase-M50	gnl\|CDD\|100081	cd06160, S2P-M50_like_2, Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the S2P/M50 family of RIP proteases use proteolytic activity within the membrane to transfer information across membranes to integrate gene expression with physiologic stresses occurring in another cellular compartment. In eukaryotic cells they regulate such processes as sterol and lipid metabolism, and endoplasmic reticulum stress responses. In prokaryotes they regulate such processes as sporulation, cell division, stress response, and cell differentiation. This group includes bacterial, eukaryotic, and Archaeal S2P/M50s homologs with additional putative N- and C-terminal transmembrane spanning regions, relative to the core protein, and no PDZ domains.	2.51936e-32
NC_014650.1\|WP_083787410.1\|3425542_3426610_-\|hypothetical-protein	gnl\|CDD\|224428	COG1511, COG1511, Predicted membrane protein [Function unknown].	8.02275e-07
NC_014650.1\|WP_013401697.1\|3435440_3435938_-\|CRISPR-associated-protein-Cas4	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	5.48408e-69
NC_014650.1\|WP_013401698.1\|3435937_3438421_-\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	4.76724e-46
NC_014650.1\|WP_013401695.1\|3430325_3431225_-\|aldo/keto-reductase	gnl\|CDD\|381364	cd19138, AKR_YeaE, Escherichia coli YeaE and similar proteins. Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.	1.48494e-179
NC_014650.1\|WP_003253168.1\|3442782_3443538_-\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	2.7267e-87
NC_014650.1\|WP_013401700.1\|3439214_3440150_-\|type-I-B-CRISPR-associated-protein-Cas7/Csh2	gnl\|CDD\|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	3.23638e-72
NC_014650.1\|WP_013401693.1\|3427076_3429161_-\|MMPL-family-transporter	gnl\|CDD\|223964	COG1033, COG1033, Predicted exporters of the RND superfamily [General function prediction only].	5.3335e-75
NC_014650.1\|WP_013401687.1\|3418140_3419418_+\|MFS-transporter	gnl\|CDD\|340913	cd17355, MFS_YcxA_like, MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters. This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.60048e-93
NC_014650.1\|WP_013401696.1\|3434430_3435438_-\|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274695	TIGR03641, cas1_HMARI, CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes Cas1 subgroup that includes Cas1 proteins of the related HMARI and TNEAP subtypes of CRISPR/Cas system.	7.19596e-169
NC_014650.1\|WP_013401701.1\|3440312_3442283_-\|TIGR02556-family-CRISPR-associated-protein	gnl\|CDD\|187861	cd09730, Cas8a1_I-A, CRISPR/Cas system-associated protein Cas8a1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Large proteins, some contain Zn-finger domain; signature gene for I-A subtype; also known as TM1802 family.	6.83714e-83
NC_014650.1\|WP_013401699.1\|3438465_3439200_-\|type-I-B-CRISPR-associated-protein-Cas5	gnl\|CDD\|187823	cd09692, Cas5_I-B, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex.	2.68143e-32
NC_014650.1\|WP_013401694.1\|3429445_3430123_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|273017	TIGR00331, Heat-inducible_transcription_repressor_HrcA, heat shock gene repressor HrcA. HrcA represses the class I heat shock operons groE and dnaK; overproduction prevents induction of these operons by heat shock while deletion allows constitutive expression even at low temperatures. In Bacillus subtilis, hrcA is the first gene of the dnaK operon and so is itself a heat shock gene. [Regulatory functions, DNA interactions].	2.06605e-05

>NC_014650.1|WP_013401695.1|3430325_3431225_-|aldo/keto-reductase
MGVLDSKKIMEIRSRIEKRVVTLPDGTTVPCIGQGTWHMGEKPQEKAKEIKALQLGIELGMKVIDTAEMYGNGASERLVGEAIKGRRDDVFLVSKVYPHNAGLDKISTACENSLKRLGTDYLDLYLLHWRGRIPLEETIEGMERLRKEGKILRWGVSNFDTDDMEELWNTTNGSNCATNQVLYHLGSRGIDFDLLPWHREHHVPIMAYSPLAQGGALRKQLLTDPIVNEIAKKYNVKPLQIALAWTIRTNDVIAIPKAGQEQHVLENAEAAAIELTQEDLKRLDEAFPKPRKKVPLDII
>NC_014650.1|WP_013401694.1|3429445_3430123_-|helix-turn-helix-domain-containing-protein
MLLTERRKQFLQKLIDLYQKTNVPVHYETLAKALGVSKWTAYDMLKELEKLGYLTRDYTLNPGETGRSQIVFLPTAKATSLFEQERSEAINLEEWHKTKEKILEFLNSLKNCSLSAAVRKVLEEIPKAQIRVAFCAYIIGLFLVYLRKLGGKTEVLIKNLVQNAPTNEMRMTMFVGTVLGSIIQTMNHEIGVEVTELVGRYLKSIADLSHFEKEMLSDFLHEALA
>NC_014650.1|WP_013401693.1|3427076_3429161_-|MMPL-family-transporter
MKSRIAIIVLSLILVIPSLFGIVKTQINYDIFAYLPEKLPSVQGQNIMNKVFGFGGTGILMVKNQTDVEVENLKRKLEQVDGVETVNWITDIADLAVPREFLPEELVDQFYSGNSTIMQIQFEEEAASEKTHYAVQEIKNILGPNTYFAGTPPMLSELRQLLESEKFVYAVSAIGFILLLLGLTLPSLFIPFLILFSIGVSIIYNLGLAYYLNGSMSYVTAAIAGALQLGVTMDFSIFLVHRYEEERKMKEKNEAMIAAIKHTAMAILTSSATAVAGFLAMVTMSLGLGEDLGMTMARGILLSVLMILTLLPSFILVFDKWIREYQHRVMIPNFHLLAKFVTNRHKLVFVVFLLLFIPAFIGFKNVHIVYDLEQLMPKTLPSIQNLDEIKKEFTSTDSAFLVMDSKISDQERLKIKQQIEEIDGIKKVIGYDTFADPAIPSEFVPENLKNMFIKDQYNYMLVQMEYGSYDERTTRAIQQINKLTEPYEGHMYLTGQAVLQNDLTTTVRDDMKKVDLISVVAVFLIIALAFRSVALPVVLVGGIELAILFNQGLDFYLGRSMPFIGTFAIGAIQLGSTINYAILLVTRYKEELMNYPKEEAMYRAITASGEAILSSALALFAAVIGIWLFSDITLLRDLTFMIARGAIISLAVILFLLPAVLLTLESFISKTTFGWPKAKSMKEDETISELSLNE
>NC_014650.1|WP_083787410.1|3425542_3426610_-|hypothetical-protein
MKNQLKQKKNISYSGYKGVRHSEEKELYTPILSLVSLNIPTEHFTDMKLGDAMTVMSGKTMSATWMVVPNPEETITLEMKGTDIELEPITITLIPKLPPVSEVSVKEQLEKLADGIQQISSALDQIGDGANQLASGNRQVKNGLNQLSEGLGQLNQVNQAHEGLVKQSLETNRQLLALAQNLAAEKPQDANLQALVQGLKGQQQMLKMLAEGGNLQGKPFPVLDKMEEGLKGSKAGADKLAAAAGQLEKGSLQLKTGIEKLSGGTAEIKNGLIAGLNKLYEGEAILHQSKTAAEQYDTFLGKPKGAKGEVRFILKTDPIEPVKAKGSAEQKPDTGSEEESISFFAKVKKWLSDLF
>NC_014650.1|WP_003253141.1|3423285_3424359_-|ABC-transporter-ATP-binding-protein
MEKEAIIRFERVTKEYDGLVVLDDVSFEIERGKFYTLLGPSGCGKTTILRLIAGFAEPTKGTIYFHGKPVNHVPANKRQVNTVFQDYALFPHLNVFENVAFGLRIKKKKRSEIEEKVQQALRFVNLEGYENRSIQEMSGGQRQRVAIARAIVNEPEVLLLDEPLSALDLKLRTEMQYELRELQRRLGITFIFVTHDQEEALAMSDQIFVLNKGKIQQSGTPKDIYDEPVNRFVADFIGESNILRGTMIEDYLVEFAGKRFTCVDKGFRPNEPVDVVIRPEDLEITTKDQGKLQVRVDSQLFRGVHYELCCYDEDGNEWLVHSTKKAEVGEEIGLYFDPEDIHVMHISEDDGEGSDEK
>NC_014650.1|WP_003253139.1|3422504_3423296_-|ABC-transporter-permease
MKNSVRNVYLLPYIIWIGLFVVAPILLILYYSFFDIDGNWTFANYKTFFTPIYLKMAASSVWYAFLITFFSLLVAYPTAYFLTKTKHKQLWLLLMILPTWVNLLLKVYAFLGIFGTYGLANAILETIGIGTKQILFTDFSFVFVSVYIFIPFMILPIFNSLEELNPTLIDAARDLGASAWTTFRRVVFPLTLDGVKAGCQAVFIPALSLFMITRLVAGNRVITLGTAIEEHFLVTQNWGMGSTIAVFLIIAMAIVVIMTGNRK
>NC_014650.1|WP_003253137.1|3421687_3422494_-|ABC-transporter-permease
MRSNKKWATVYLVFVFLILYTPIIYLIYYSFNSGGMMHDFQHFTLKWYQEVLHDTRLWIIVLNTLTIALLSAAISTILGVIGALAIYYVKKRHMKQLLLTLNNVLIVSPDVIIGASFLILFTIIGIQLGFTSVLLSHIAFSVPIVVLMVLPKLQEMSPTLIDAARDLGANQWDVLTKVILPFITPGIFAGFFMALTYSLDDFAVTFFVTGNGFSTLSVEIYSRARQGISLSINALSTLLFLFTVVLVIGYYFISQKSSTLYGMRGRRK
>NC_014650.1|WP_013401689.1|3420617_3421691_-|ABC-transporter-substrate-binding-protein
MRKLISLFAAVFFASFVLLYVSALLNKTEGYSGKNTLTVYNWGDYIDPALIKKFEKQTGIKVIYQTFDSNEAMMAKIAQGGTTFDVAVPSEYAISKMKEEGLLIPLDHSKLPNLKYINPRFLNLSFDPGNKYSVPYFWGTVGIVYNPEMIGGKKITSWNDLWDKDLRNQILLVDGAREVIGMGLNSLHYSLNDTNKKHLQEAKEKLDRLTPNVKAIVGDEIKMLLVNEEAAIGVVWSGDAAEIIAENDKLDYVVPKEGSNLWFDNMVIPKTAKNIEGAHQFINFMLDPKNAAQNAEYVGYSTPNEKALDYLPKEVTEDKRFYPDFESVGNLEVYENLGKRMLAYYNELFLQFKMHRK
>NC_014650.1|WP_013401688.1|3419487_3420594_-|peptidase-M50
MKRLKKAWIAFLSVVLFLSGKLKWVLAVFKFLKFSSLISLFISIGAYAMVYGWKFAVALVYLLYVHEMGHLFAAKRLGIPTSKAIFIPFVGALIALKEKPKSAKDEAYLAYAGPLWGTLGFLPALPLFWMTGDPFWGLVIALGALINLFNLMPLHPLDGGRIAGVISPKLWFVGLMGMTAYFLWKPGPIAPLIILLGAVKCWELLRREFRWKKAQIHKEVNESLLREIQRYMLLSEEEQQEMYWRWEDELERAEAELQRRKTWHIPVFQDEQKLQNYRLERYVEKHHQLLEATRWGALQEQTVPDFIRVLQKEIEENEQAIQKQTVYYRAEAKTKWAWLCLYLALAVVLAVFTAYGQQIMDANQPLIS
>NC_014650.1|WP_013401687.1|3418140_3419418_+|MFS-transporter
MNSGHSSSTLTSHHIYWIVAGVTFLTLLVSAGVRSTPGVLIVPFELSFGWTRAEVTFPLAINIALYGLCGPFAAAFMERYGVKRMMLIALSLLVAGTGLSVWMKTTWQMTLLWGFLVGTGAGFTSSVLGAVIANRWFKEKRGLVVGVFSASGAAGQLVFLPLFAKMISSYGWQTVVLATSLSALLTMLCVGWFMRDKPSDVGLLPYGATEPVETASAPYANPFLSALNGLKMGARSKDFWLLAGSFFVCGLSTNGLIGTHLIPACMEHGIPEVTAASMLAVMGIFDILGTTLSGWLSDRWNNRWLLFWYYGLRGISLVFLPYALDSTFLGLSVFVVFYGLDWVATVPPTVRLCSDVFGKQSGVVFGWVWAFHQLGAAAAAFGGGILHTWFGTYTFIFIVAGILCVTAAGFVLQIHREKKAAAHSV
>NC_014650.1|WP_003253157.1|3433136_3433883_-|CRISPR-associated-endoribonuclease-Cas6
MRMIIQFRPKNGALILPINYEEVLQGFLYRSIQDFELAHFLHDVGYTKEKRRFKMFTFSRLYGTYRIHRHEKKIEFFDQVTWYISSALDSLIVNLAQNYLLREQFALNGQPIHIEETAVKRLEISEKRSYQIRMLSPLTVYSTYENQHGEKRTHFFSPFDAEFSKMVEKNFYNKFQAYFQQAPTEKVTISPIRVTKRDKVITVFKGFRINAWNGMYEIQAPLPYVKFMYDVGIGSKNSQGFGMFEFIE
>NC_014650.1|WP_003253159.1|3434157_3434421_-|CRISPR-associated-endonuclease-Cas2
MFVILVYDFEKKRVAKALKIARKYLYWVQNSVFEGEISEANYVKLKMELENIMDPDVDSVVFYTFRTQKYSKREEMGLRKGGEENIL
>NC_014650.1|WP_013401696.1|3434430_3435438_-|type-I-B-CRISPR-associated-endonuclease-Cas1
MKKTLYIFQSGELSREDNSICFETTERKQKLPVEDVNDIYIFGEVNATKKFLELMAQKNICIHYFNHYGYYTGTFYPREHLNAGHVILKQAETYLDPEKRLVLARKFIDGSIGQMIQVLKYYQNRVKANNAKFKEMILDFQSSRAKLEQWTSVEEMMSTEGHVREKYYSMFDDILNHNPDFLFEKRSKRPPLNRLNAMISFGNQICYTMVLSEIYKTYLDPRIGFLHATNFRRFSLNLDVAEIFKPIMVDRLIFTLVNKKMITKKDFDKHMEGILLSEEGRKKFVGELDKRMKTTVNHRHLGKSVSYRRLIRLELYKIQKHLLGEKEYEPYRSLW
>NC_014650.1|WP_013401697.1|3435440_3435938_-|CRISPR-associated-protein-Cas4
MDVNGTHIWYYFICKREVWLIAHQIAADQEDDNLEIGRFISETSYQRQKKELLIGNIKVDRIRREGDMLVVGEVKKSSTYEKSAYYQLLFYLDTLRKMGIEAKGELLFPKEKKVTKVEWTEEGKRVLEEAVADIRRIARLPVPPEPKKIGFCRSCAYREYCFAEE
>NC_014650.1|WP_013401698.1|3435937_3438421_-|CRISPR-associated-helicase/endonuclease-Cas3
MYLSHNNPDKKLTVHLKEVYEYSQDMLKHVPLSDENRDMLEYISKIVAVAHDFGKYLSYFQDYLRTGETNGDLHHHSFISAVFAAHLLRHPANLNASWSEFAPLLGYFVVMHHHGNLRDISLDVTKSRHIAENTVQDSLYYRVNTLKQQIDDIKNHASAIVEDLSPLWDELSIPLSLSAELHSFLQNYEKAFDEVYRQYYLIDKRRKQELTRELYYYVLLLYSVLIDADKLSAANIERKPRVHIPAHLVDQYREANFDVNVTEGTNGWRNRMYNVVMERIEELFKTKPEQRLFTLTAPTGAGKTLLSLSVALKWREQTERQHGYTPKIIYALPFTSVIDQNEKVIRDLLSQLADFHANEQRYLVKHHHLSTFQYRTENEELPLRKALLLTESWEAELIVTTFVQLFHTLIGYENRALKKFHQIAGSIIILDEIQNVPMEYWPLLRSVLYKMAELFSCKILLLTATQPLIFPEGETVELLESELVKPIDFFKEMERVELHWLGGDKGAYSPAEWMELFQNRFEDGKTYLAIFNTIKTSIEIYEGIKEWLKERGYDVIYLSTNIVPCERKRRIERIRQLLKEKKKVVVISTQVVEAGVDVDFDVVYRDLGPIDSIVQAAGRCNRNGKLHELGKVYITPMEREGKLESQYVYKGVHTNIAKEVLPKTPVSEHQFFDIIMQYFTEVRGKKSFDASDGIISAMEELKFDAKDKSGSKNKPKYVSEFQLIENAHQAVDVFVEVDDQAMDIWQQYIQKVVEEKDFETRFENYLRLKKDVRQYVISAPIKLVKNLDRDLYEKTRMIHLANDILNQYYNSEYGLIRTSEMVDAWIM
>NC_014650.1|WP_013401699.1|3438465_3439200_-|type-I-B-CRISPR-associated-protein-Cas5
MKMLIFDLIGKMGHFRKIDTNSSSLSYAFPPRTTIVGMIAGILGMERDSYYEVFSPDQCQIAISVRTPIRKVMQTVNYMFVKSKAHLNNSGGHTQIPLEFVLPGGEEANLRYRIYFSHSDRSVYESVKERIQSGRYVYPPYLGLSELLGQLQWVAEAEGMLKESNDLVPIHSVVRIPDLRERSIQFSRDTRFLKEFMTRQFTNERMIQETDYYLFEQSRQLIAVPAVPYIAVAYGEAKENILWM
>NC_014650.1|WP_013401700.1|3439214_3440150_-|type-I-B-CRISPR-associated-protein-Cas7/Csh2
MNNSDILFLYDAKLTNPNGDIDEENRPRMDYERSLNLVSDVRLKRYIRDYLEQIGHEIFVGKVDGETVNATERMKRLFEKYDGKVNINKLSKEQQNWMLDQFIDVRMFGATMPIKSEDKGSSMTFTGPIQFNWGYSLNKVTLVESASITSHFGSDDKNDGGNIGKDYRVYYSFLAFHGVISGHRAAHTRLTEEDIHLFDQAVVKAIPLSATRSKVGQYPRLYVRVEYHSPEFIAGDLRDLVHLEETEGLRSISEVTLHVDALVNKLLEVNGEIARIHYWQDSNLTLNYEGQKGLLADLLPSELADKLVSVL
>NC_014650.1|WP_013401701.1|3440312_3442283_-|TIGR02556-family-CRISPR-associated-protein
MIKTIYTLGSKYLTEEKPSMIQAMTLPIAKSDGATKYVVIVDFSIAEKKIRLTPKEIGASTSSELLWIGTADGAASPQWYGTVSNVEYLLSQTIPNLLERWDQKDFYYSLLKEARDVFFLDLGAAKKSDERYRYVFNPAYVSGELTETEGKKAVKEVAKQFQAFMEKEANVNIKDVLLYSLAINGQLVVSQPEYERLVIAEKLSVFEDAKKGVCALTNKEAFVTGETTKLKFNYYINDKISFASDLEKKSFVKNLSISKDAYQAIMAGEAYILRHFNTRFSGLPCYIIPDFLYDVPFANVPLQDISEHIHQFVRTVKTVETAEDLHREIEDYKEFDEQMDNHISLHFLFYTKAQSALKVNKLLSDVPLTHLRRLSFEMRKTGEIGQRFFGSEKFNLGLEPIYYLIPMRVQRGENFEKRKILQVYESLLTNKPLSYRWLITQFVQLAKVHMYANYNLYQYSSDKEEPNDFRLVNAMVRAQLFLKMLQNLNLIKEEREMTKVTYDLPDAHMIEYMETMNYNVAQSSLFLLGYLIAKIGAEQVRRTKARAEALGQAWGGKTVNKPILSKINYHGMNKQRLMLLSHEVFDKLRQLKIASLQNETVYIEHKRLFDLALQEKWNLSDRESVFYLLSGYAYGTKRILNSSKKDNSDPDFENEE
>NC_014650.1|WP_003253168.1|3442782_3443538_-|DeoR/GlpR-transcriptional-regulator
MLAIERRQKIIEIIQKDKRALVSDLSKRFNVTEETIRRDLEKLEKEGIVTRTYGGAILNQHTNVDLPFATRKDINIPIKQEIAKKAINYIDERDSLFVDSSSTCFELVKLLENNRIVTVITNSAKILNEISSDSLHIISTGGTLRPYSSSLVGSIPQETVKKYNTDWAILSCKGIDMNRGIMDSNELDAELKKVMVQQASKTMMLVDHTKFDKVAFTSFLDFQQIDYLVTDKKPSDEWIKFLHEQNVTVIY
>NC_014650.1|WP_013401702.1|3444462_3445740_-|MFS-transporter
MADGAKGGLKATITVAMSNYLEAGSIVAGAGGLSLWVEYLKLDDIKVGLLGAVSANGFGSAVGAFIGGILVDRFGRKFIYKYDLLVYMLGVLLITLSFNFPMLLLGYIITGLAVGAGIPAAWTYISEEAPANERAARVGWGQFARSVGPVISLLLSVLLAPLGILGSRIIFAQLFVVAAITWIMQQQIRESMIWEEERQKQAELKAKYQISKSSTKELFTIKANLHAMILLIGIYCFWNLVAGVMGYFMPYIYEKVGGLTAAQANLLQAFLWILTVASTYFVFIKLGDKVNRRVLYGLGALMEIVAWIILSFAGMGKIQLMLFVILWGTAAGFGAQAFYALWAGELFHTKYRAKAQGFLFSVARIAVGLISLVVPTMITQLGFKFAGTVMIGFLLIAAIIGVAMAPETRGKTLKEIQQERYGTNY

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Crispr_ID: NC_014650_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014650_13

3536448-3536556

Orphan

Consensus_repeat	Method
CTTGCAGACGCAGGCACAAGACTGCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014650_13

>merge|NC_014650|13|3536448-3536556|CRISPRCasFinder
CTTGCAGACGCAGGCACAAGACTGCTACCTTGTGCTCACTTCTTTGCTGTCTTGCGTCGAGGAATCCAACTTCTTTGCATTCACTTGCAGACGCAGACACAAGACTGCT

>NC_014650|13|13|3536448-3536556|CRISPRCasFinder
CTTGCAGACGCAGGCACAAGACTGCT	ACCTTGTGCTCACTTCTTTGCTGTCTTGCGTCGAGGAATCCAACTTCTTTGCATTCA
CTTGCAGACGCAGACACAAGACTGCT

Protein	Signature genes	Signature genes Name	Protein_function
NC_014650.1\|WP_003253350.1\|3544011_3544554_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|224584
NC_014650.1\|WP_013401757.1\|3540129_3540828_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_014650.1\|WP_013401756.1\|3538712_3540143_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NC_014650.1\|WP_003253335.1\|3531493_3531982_-\|5-(carboxyamino)imidazole-ribonucleotide-mutase	unknown	unknown	gnl\|CDD\|223119
NC_014650.1\|WP_013401755.1\|3530358_3531510_-\|5-(carboxyamino)imidazole-ribonucleotide-synthase	unknown	unknown	gnl\|CDD\|235674
NC_014650.1\|WP_003253351.1\|3544641_3545967_-\|NCS2-family-permease	unknown	unknown	gnl\|CDD\|225161
NC_014650.1\|WP_013401760.1\|3542620_3543409_+\|lantibiotic-immunity-ABC-transporter-MutG-family-permease-subunit	unknown	unknown	gnl\|CDD\|163445
NC_014650.1\|WP_013401751.1\|3523737_3525150_-\|amidophosphoribosyltransferase	unknown	unknown	gnl\|CDD\|181061
NC_014650.1\|WP_041269519.1\|3541159_3541858_+\|lantibiotic-protection-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|163452
NC_014650.1\|WP_013401754.1\|3528267_3528990_-\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	unknown	unknown	gnl\|CDD\|181800
NC_014650.1\|WP_003253337.1\|3532346_3532793_+\|Hsp20/alpha-crystallin-family-protein	unknown	unknown	gnl\|CDD\|223149
NC_014650.1\|WP_013401752.1\|3525125_3527354_-\|phosphoribosylformylglycinamidine-synthase-subunit-PurL	unknown	unknown	gnl\|CDD\|234921
NC_014650.1\|WP_003253353.1\|3546265_3547804_-\|glutamine-hydrolyzing-GMP-synthase	unknown	unknown	gnl\|CDD\|234614
NC_014650.1\|WP_013401762.1\|3548006_3550169_-\|DUF4129-domain-containing-protein	unknown	unknown	gnl\|CDD\|376628
NC_014650.1\|WP_003253326.1\|3527337_3528024_-\|phosphoribosylformylglycinamidine-synthase-subunit-PurQ	unknown	unknown	gnl\|CDD\|235140
NC_014650.1\|WP_003253332.1\|3529066_3530362_-\|adenylosuccinate-lyase	unknown	unknown	gnl\|CDD\|176464
NC_014650.1\|WP_013401761.1\|3543461_3543905_+\|NisI/SpaI-family-lantibiotic-immunity-lipoprotein	unknown	unknown	gnl\|CDD\|375645
NC_014650.1\|WP_013401750.1\|3522682_3523723_-\|phosphoribosylformylglycinamidine-cyclo-ligase	unknown	unknown	gnl\|CDD\|235439
NC_014650.1\|WP_013401753.1\|3528020_3528275_-\|phosphoribosylformylglycinamidine-synthase-subunit-PurS	unknown	unknown	gnl\|CDD\|235659
NC_014650.1\|WP_013401759.1\|3541872_3542619_+\|lantibiotic-immunity-ABC-transporter-MutE/EpiE-family-permease-subunit	unknown	unknown	gnl\|CDD\|274754

Protein	Function_ID	Function_description	E-value
NC_014650.1\|WP_003253350.1\|3544011_3544554_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	2.00835e-32
NC_014650.1\|WP_013401757.1\|3540129_3540828_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.67644e-75
NC_014650.1\|WP_013401756.1\|3538712_3540143_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	2.98352e-38
NC_014650.1\|WP_003253335.1\|3531493_3531982_-\|5-(carboxyamino)imidazole-ribonucleotide-mutase	gnl\|CDD\|223119	COG0041, PurE, Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism].	2.82433e-93
NC_014650.1\|WP_013401755.1\|3530358_3531510_-\|5-(carboxyamino)imidazole-ribonucleotide-synthase	gnl\|CDD\|235674	PRK06019, PRK06019, phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed.	0
NC_014650.1\|WP_003253351.1\|3544641_3545967_-\|NCS2-family-permease	gnl\|CDD\|225161	COG2252, COG2252, Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism].	5.24123e-162
NC_014650.1\|WP_013401760.1\|3542620_3543409_+\|lantibiotic-immunity-ABC-transporter-MutG-family-permease-subunit	gnl\|CDD\|163445	TIGR03733, lanti_perm_MutG, lantibiotic protection ABC transporter permease subunit, MutG family. Model TIGR03731 represents the family of all lantibiotics related to gallidermin, including epidermin, mutatin, and nisin. This protein family is largely restricted to gallidermin-family lantibiotic cassettes, but also include orphan transporter cassettes in species that lack candidate lantibiotic precursor and synthetase genes. In most species, this subunit is paralogous to an adjacent gene modeled separate by TIGR03732, while in some species only one subunit is found.	3.68541e-73
NC_014650.1\|WP_013401751.1\|3523737_3525150_-\|amidophosphoribosyltransferase	gnl\|CDD\|181061	PRK07631, PRK07631, amidophosphoribosyltransferase; Provisional.	0
NC_014650.1\|WP_041269519.1\|3541159_3541858_+\|lantibiotic-protection-ABC-transporter-ATP-binding-protein	gnl\|CDD\|163452	TIGR03740, galliderm_ABC, gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit. Model TIGR03731 represents the family of all lantibiotics related to gallidermin, including epidermin, mutatin, and nisin. This protein family describes the ATP-binding subunit of a gallidermin/epidermin class lantibiotic protection transporter. It is largely restricted to gallidermin-family lantibiotic biosynthesis and export cassettes, but also occurs in orphan transporter cassettes in species that lack candidate lantibiotic precursor and synthetase genes.	1.618e-137
NC_014650.1\|WP_013401754.1\|3528267_3528990_-\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	gnl\|CDD\|181800	PRK09362, PRK09362, phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed.	5.12559e-149
NC_014650.1\|WP_003253337.1\|3532346_3532793_+\|Hsp20/alpha-crystallin-family-protein	gnl\|CDD\|223149	COG0071, IbpA, Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones].	1.88003e-17
NC_014650.1\|WP_013401752.1\|3525125_3527354_-\|phosphoribosylformylglycinamidine-synthase-subunit-PurL	gnl\|CDD\|234921	PRK01213, PRK01213, phosphoribosylformylglycinamidine synthase subunit PurL.	0
NC_014650.1\|WP_003253353.1\|3546265_3547804_-\|glutamine-hydrolyzing-GMP-synthase	gnl\|CDD\|234614	PRK00074, guaA, GMP synthase; Reviewed.	0
NC_014650.1\|WP_013401762.1\|3548006_3550169_-\|DUF4129-domain-containing-protein	gnl\|CDD\|376628	pfam01841, Transglut_core, Transglutaminase-like superfamily. This family includes animal transglutaminases and other bacterial proteins of unknown function. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that form the catalytic triad in the structurally characterized transglutaminase, the human blood clotting factor XIIIa'. On the basis of the experimentally demonstrated activity of the Methanobacterium phage pseudomurein endoisopeptidase, it is proposed that many, if not all, microbial homologs of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease.	4.00354e-27
NC_014650.1\|WP_003253326.1\|3527337_3528024_-\|phosphoribosylformylglycinamidine-synthase-subunit-PurQ	gnl\|CDD\|235140	PRK03619, PRK03619, phosphoribosylformylglycinamidine synthase subunit PurQ.	2.64075e-166
NC_014650.1\|WP_003253332.1\|3529066_3530362_-\|adenylosuccinate-lyase	gnl\|CDD\|176464	cd01360, Adenylsuccinate_lyase_1, Adenylsuccinate lyase (ASL)_subgroup 1. This subgroup contains bacterial and archeal proteins similar to ASL, a member of the Lyase class I family. Members of this family for the most part catalyze similar beta-elimination reactions in which a C-N or C-O bond is cleaved with the release of fumarate as one of the products. These proteins are active as tetramers. The four active sites of the homotetrameric enzyme are each formed by residues from three different subunits. ASL catalyzes two steps in the de novo purine biosynthesis: the conversion of 5-aminoimidazole-(N-succinylocarboxamide) ribotide (SAICAR) into 5-aminoimidazole-4-carboxamide ribotide (AICAR) and, the conversion of adenylsuccinate (SAMP) into adenosine monophosphate (AMP).	0
NC_014650.1\|WP_013401761.1\|3543461_3543905_+\|NisI/SpaI-family-lantibiotic-immunity-lipoprotein	gnl\|CDD\|375645	pfam18218, Spa1_C, Lantibiotic immunity protein Spa1 C-terminal domain. This is the C-terminal domain found in SpaI present in Bacillus subtilis. SpaI is an immunity lipoprotein that protects the Gram-positive bacteria against their own lantibiotics, in this case subtilin. SpaI together with the ABC transporter SpaFEG protects the membrane from subtilin insertion.	3.05854e-37
NC_014650.1\|WP_013401750.1\|3522682_3523723_-\|phosphoribosylformylglycinamidine-cyclo-ligase	gnl\|CDD\|235439	PRK05385, PRK05385, phosphoribosylaminoimidazole synthetase; Provisional.	0
NC_014650.1\|WP_013401753.1\|3528020_3528275_-\|phosphoribosylformylglycinamidine-synthase-subunit-PurS	gnl\|CDD\|235659	PRK05974, PRK05974, phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed.	5.87071e-41
NC_014650.1\|WP_013401759.1\|3541872_3542619_+\|lantibiotic-immunity-ABC-transporter-MutE/EpiE-family-permease-subunit	gnl\|CDD\|274754	TIGR03732, lanti_perm_MutE, lantibiotic protection ABC transporter permease subunit, MutE/EpiE family. Model TIGR03731 represents the family of all lantibiotics related to gallidermin, including epidermin, mutatin, and nisin. This protein family is largely restricted to gallidermin-family lantibiotic cassettes, but also include orphan transporter cassettes in species that lack candidate lantibiotic precursor and synthetase genes. In most species, this subunit is paralogous to an adjacent gene, modeled separately.	5.86472e-80

>NC_014650.1|WP_003253337.1|3532346_3532793_+|Hsp20/alpha-crystallin-family-protein
MKSNPFDPFFDWTKHLEHFFQGDFWSSFQPFLPPAKKQSGISGINIYKKDNELLIVVSLPGLEKMEDVELYVYYKTLEIKANINLQFKGFELIEEGIFQGTWEKTIPIPFAIKEDRIEATYHNGLLFIHLHRLIPDETKKKIEIKKGE
>NC_014650.1|WP_003253335.1|3531493_3531982_-|5-(carboxyamino)imidazole-ribonucleotide-mutase
MQPLVGVIMGSQSDWETMKHACDILEELQIPFEKKVVSAHRTPDYMFEYAETAEKRGIKVIIAGAGGAAHLPGMVAAKTTLPVIGVPVQSKALNGLDSLLSIVQMPGGVPVATVAIGKAGATNAGLLAAAMLGIHYPHYMEALKKRREMMRKSVMESSDHLV
>NC_014650.1|WP_013401755.1|3530358_3531510_-|5-(carboxyamino)imidazole-ribonucleotide-synthase
MIILYKQIVPGQTIGIIGGGQLGRMMAIAAKEMGFRVAVLDPTPDSPCGQVADIEIIAEYNDFAAIQKLAAVSDVITYEFENIDADALNWLVEHAYVPQGSRLLAITQDRASEKKAITDAGLPVAPYVKVQSKEDLFSGIETIGLPCVLKTCRGGYDGKGQFVIRSKEDSVQALSLLETGPCVLERWLSFDKEISVIVTRNGYGAMAVFPVAENIHIDNILHKTIVPARISGHIAKKAVRYAETLADYFGLVGTLAVEMFLTKEGDIYINELAPRPHNSGHYTINACATSQFAQHIRAVCNWPLGSTELLKPAVMVNILGEHVEPIIQNIATLRDAHLHLYGKKEAKPKRKMGHVTVLAEHTDAALKTIDAWQIWNDRRKEYV
>NC_014650.1|WP_003253332.1|3529066_3530362_-|adenylosuccinate-lyase
MIERYTRPEMGAIWTEENRFRAWLEVEILACEAWAELGVIPKEDVERIRQNASFDIARIKEIEEETRHDVVAFTRAVSETLGEERKWVHYGLTSTDVVDTALSYLLKQANEILLKDLENFIQALKEKALEHKYTVMMGRTHGVHAEPTTFGLKMALWYAEMQRNLERFKQAAETVRVGKISGAVGTYANIDPFVEQYVCEKLGLKPAPISTQTLQRDRHAYYMATLALIATSIEKFAVEIRGLQKSEVREVEEFFAKGQKGSSAMPHKRNPIGSENMTGMARVIRGYMLTAYENVPLWHERDISHSSAERIILPDATIALNYMLNRFTNIVKNLKVYPENMKKNMDRTLGLIYSQRVLLSLIDAGMTREEAYDLVQPKAMEAWEKQVPFRSLIEADERITSRLTKEQIDDCFDYRYHLKHVDTIFERLGLS
>NC_014650.1|WP_013401754.1|3528267_3528990_-|phosphoribosylaminoimidazolesuccinocarboxamide-synthase
MVNKLALLYEGKAKKVYTTDDANILWIEYKDNATAFNGEKKATIAGKGRLNNEITSLLFSKLHEAGIPNHFIQKLSATEQLVKKVTIIPLEVVVRNVVAGSLAKRLGIPEGTRLEKPLIEFYYKNDDLGDPLLLEDHIAILKLATSEQIAVLKELALQVDDVLTKHFAERRVRLIDFKLEFGIDSEGAILLADEISPDTCRLWDMDTDEKLDKDVFRRDLGNLTDAYETILQRLGGESNV
>NC_014650.1|WP_013401753.1|3528020_3528275_-|phosphoribosylformylglycinamidine-synthase-subunit-PurS
MYKVKVYVTLRESVLDPQGTAVKGALHSLSYTEVQDVRIGKFMELIVEKSERDINELVREMCEKLLANTVIEDYRYEIEEVVVQ
>NC_014650.1|WP_003253326.1|3527337_3528024_-|phosphoribosylformylglycinamidine-synthase-subunit-PurQ
MKFAVIVFPGSNCDVDMYHAIADELGEEAEYVWHDAANLDRFDAILLPGGFSYGDYLRSGAIARFSNVMNAVQKAADEGKPILGVCNGFQILLEAGLLPGAMRRNNSLKFICRPVSLKVENNETMFTSAYKQGEVITIPIAHGEGNYYCDEQTLKRLMENRQIVFRYHGENPNGSLDGIAGIVNEKGNVLGMMPHPERAVDPLLGSADGLRLFQSIVKYWRETHAVTA
>NC_014650.1|WP_013401752.1|3525125_3527354_-|phosphoribosylformylglycinamidine-synthase-subunit-PurL
MPLLLEPSPTTIKEEKLYREMGLTDEEFAMIEKILGRLPNYTETGIFSVMWSEHCSYKNSKPVLKKFPTEGKHVLQGPGEGAGIVDIGDGLAVAFKIESHNHPSAIEPYQGAATGVGGIIRDVFSMGARPIALLNSLRFGELTSPRVKYLLEHVVAGIAGYGNCVGIPTVGGEVQFDPAYEGNPLVNAMCVGIIRHEDIQRGIASGVGNTVMYVGAKTGRDGIHGATFASEELTEQSEEKRPAVQVGDPFMEKLLLEACLEVVKSDALIGMQDMGAAGLTSSSAEMASKGGFGIEMNLDLVPQRETGMTPYEMMLSESQERMLLVVQQGREQEIYDLFAKYGLEAKAIGKVTDDKMLRLYFRGEVVAEIPVDALAKDAPVYFKPSKEPAYYREFQAMEPYIPVVTNYEETLLALLAQPTIASKEWVYQQYDYMVRTNTVVAPGSDAAVVRIRGTNKALAMTTDCNSRYIYLDPETGGKIAVAEAARNVVCSGAKPLAITDCLNFGNPEKPEIFWQLEKAVDGMSAACRALGTPVISGNVSLYNETNGEAIYPTPVVGMVGLVEDIRHITTQAFQQAGDLIYVIGEAKQEFGGSELQKLLEGRIFGKAPAIDLATEAKRQRELLAAIQAGVVASAHDIAEGGFAVALAECVMSTDGLGAKVTVDGDMTAQLFSETQSRFIVSVKKEDRETFEQLVDAKLIGEVTNDGMLLVEKGDGEVVIRLSAAQMRNVWKGAIPCLLKSKD
>NC_014650.1|WP_013401751.1|3523737_3525150_-|amidophosphoribosyltransferase
MLAEVKGLNEECGIFGIWGHEEAAQITYYGLHSLQHRGQEGAGIVVAHQGMLQGHKGLGLVTEVFSDGELQSLKGAAAIGHVRYSTAGGGGYENVQPLLFRSQTGSIALAHNGNLVNAMDLKMQLEEQGSIFQTTSDTEVFAHLIRRSHAPTLKEQIKEALTFVEGAFAFLLLTETELYVALDPHGFRPLSIGRLGNAYVVASETCAFDVVGAAYEREVEPGELIVISAEGMRSERFAPAQARSICSMEYIYFARPDSNVDGINIHTARKNLGKRLALEAPVEADIVTGVPDSSISVAIGYAEATGIPYELGLIKNRYVGRTFIQPSQSLREQGVKMKLSPVRGVVAGKRVVMVDDSIVRGTTSKRIVAMLREAGATEVHVRISSPPITHPCFYGIDTSTREELIASKYTVKEIRQMIGADSLAFLSQEGLLEAIGRSPHLPLRGQCMACFTGNYPTNIGRVRSPLMSTK
>NC_014650.1|WP_013401750.1|3522682_3523723_-|phosphoribosylformylglycinamidine-cyclo-ligase
MAEAYKQAGVDIEAGYKAVSLMKEHVRKTARPEVLGGLGGFGGMFDISSLGYREPVLVSGTDGVGTKLKIAFMMDCHDTIGIDCVAMCVNDIVVQGAEPLFFLDYIACGKAVPEKIAQIVKGIADGCVEAGCALIGGETAEMPGMYAEDEYDIAGFAVGIAEKSKLVTGSAIREGDALIGLASNGLHSNGYSLVRRIVFEQAKLALDRVYEPLSIPLGEELLKPTRIYVKPLLHVMKQFDIKGMAHITGGGFLENIPRMLPEGLGAEIDCGSWPVPPIFDLLQEKGNLLRRDMFSVFNMGIGMVIAVDSEMIDPVMASLEELGEKAYFIGRVKRGKGVSFSGGAVS
>NC_014650.1|WP_013401756.1|3538712_3540143_-|HAMP-domain-containing-histidine-kinase
MKKDKTIKRDFYLLVVKVFLSTLISTFITYVCLFLFIFVLTNNNTIKPSNYYVKYIDSIEKKIKENSSSILKGQLIDLKSYHENIQGEVLDINGNHMYGDKGIVDGRIDFSKVINHEIVKGKYVYRYIPVQHNNSIQAVYVIKVPFGFFINNIKDNPGAVFIYILLLISPLLFFIIYLVLFTSKLYKSLFNNIKVLLQAADKISNGDFDFQVHGLRRDEFIKIQNSFNTMINALKETIENLSKIDDERKMMVSSIAHDIRTPLTVIQGQMDLIADLKNQDNFDITPHLDIIRNNCYKMVMLTDNLSLLYKVEKADFLLNIKKIDLNKMLMEKKQEISAVAHNKRNLAIKFDINLNKQFYLLDESMLGRVLDNILYNSLRFTMSGEIKLEVHDEVDEHGNKIYFKCMDTGIGFRQKDTSILFEAFYQDKHYRNHIGLGLYISKKIVNNYGGEIWAYNNEKGGATVEFYIKEFSDSLL
>NC_014650.1|WP_013401757.1|3540129_3540828_-|response-regulator-transcription-factor
MNKKKILVVDDNEDICLTIKQYLELYHYFVEAVHSGSEALRIINNNFDLIILDIMMEGIDGMELCSMIRDRVDCPIIFVSAKTLEEDKIQALSVGGDDYISKPFSLKELKARIDCHLRREERIRSNERQLLSSKNITIDLLANEVFCKGVKLHLTKKEYEIMKLLMLNKNMVFSKERIFESVWGLDSESQLETVTESIKNIRKKIRSLDPEHSYIKTLYGLGYKWDVTYEKG
>NC_014650.1|WP_041269519.1|3541159_3541858_+|lantibiotic-protection-ABC-transporter-ATP-binding-protein
MEEYILQTNKLSKSFGKQLAVDNVSLKVKTNTIYGLLGPNGAGKSTTLKLLTGLFHPTSGEIIFNGHPWSRKDLKDIGVLIESPALYGNLTAYENLLVHTKVLHLPESRIQEVLKIVGLENTGKKKVSQFSFGMKQRLGIAKALLNHPKLLILDEPTNGLDPLGIQELRKLIRSFPSQGMTVILSSHILSEVAQLADHIGIIHHGKLKYQGEIEKNKDLEKLFMDVVSEKAK
>NC_014650.1|WP_013401759.1|3541872_3542619_+|lantibiotic-immunity-ABC-transporter-MutE/EpiE-family-permease-subunit
MLNMIQSENLKYKRTFTKKIVYISPLFFILYAIITMPSIHSKYNYFEYTVFNWWPLIFMPLGTALISSLSAMREKKSGNYRVLRCHNISVAHMWFSKIIVVALYTLLSSIELILLLFILKFFLPSSITSAVVVIQASLAVWVTSLAYIPIGLFFAERFGTAISIIVNVLGIVIGVVMAPEPYWIYIPWSWGMRLMSPIVGVHPNGTPLETGSPLLNPSVIPLGIAVSIVFFIMLSFATAIWFSKKEVN
>NC_014650.1|WP_013401760.1|3542620_3543409_+|lantibiotic-immunity-ABC-transporter-MutG-family-permease-subunit
MSFLQVLSSEWVKTKRTSIRLIVFAIPIAYPVCMLWYFSKYNDPLSWQMKIYSGFFEVLTVSLPVIVSLLTGLISHQEEKAGNFVGLLVAPVSRAQLYVSKLVLLILLAIMDIFLATSLMLLGMDYILHVDNVHCGLFLQGALLSVIGSLILFSMHLFISFAYGMGASIAIGGGGFLISAIIGATVVGDDIWPFIPWAWAVRLSKIPILLMPEAKLADGIQPSEFFLQELVKGIMPSIICFVLVTIGGIMWFNRWEGNKSHE
>NC_014650.1|WP_013401761.1|3543461_3543905_+|NisI/SpaI-family-lantibiotic-immunity-lipoprotein
MKIKNSILSLLLIASTSLGGCSLISELKHTASKNMAIDKRLPIYELNKQNFKEITYKDKTYIIQKSVIKPGSLQKPIGRVSQSITINEKNEMLSKKELRKVEILPNKKEEKRFHLNFGWVYSIKNISPDEKIAVVVNNEYRVAKIKK
>NC_014650.1|WP_003253350.1|3544011_3544554_-|GNAT-family-N-acetyltransferase
MFIHRLDDDSWLKLLTAEDAEALFALIDSCRPHLRKWLPWVDWTQTAEDSKAFIAGGLQKFAVGSGFEAGIWHKGQLAGVIGFHYIDHANKKTSIGYWLGEQFQGIGLMTKACKAFVDYAFHDLKLHRVEIRCAVENKKSRAIPERLGFTNEGTIREAEWLYDHFVDHVVYGMLAREWKH
>NC_014650.1|WP_003253351.1|3544641_3545967_-|NCS2-family-permease
MKKYFQFEELGTNYRTEIIAGLTTFLSMAYILFVNPFTLSLGAVKDFPDELRIDQGAVFVATALAAAYGCILMGVLARYPIALAPGMGLNAFFAFTVVLHMQIPWQTALAGVFVSGVIFTILSLTGIREKIIDAIPVELKYAVGAGIGLFITFIGLQNAKIIVDNQATLVGLSDLKDGNTLLAIFGLFVTVILMVKRVNGSVFYGMVITAIVGMIFGLIKVPDKIVGAIPDISPTFGVAIEHLPDIFSLKMLGVILTFFIVDFFDATGTLLAVANQAGLLKDNKLPRAGKALLVDATAVMVGAVLGTSTTTSYVESSAGVAAGGRSGFSAVVTGILFLLALFFSPLLSVVTAPVTAPALIIVGVLMVSSIGEIDWKKLEIAIPAFFTLITMPLSYSIATGIAVGFIFYPITMILKGRGKEVHPILYALFVIFILYFVFLRE
>NC_014650.1|WP_003253353.1|3546265_3547804_-|glutamine-hydrolyzing-GMP-synthase
MEQKQEMIIVLDFGSQYNQLITRRIRELGVYSELHPHTITADKIQEMNAKGIIFSGGPNSVYDDNAFACDPQIFELGLPILGICYGMQLMTHHLGGKVEKATHREYGKAMIQVKNASALFKRLPDEQVVWMSHGDLVTAPPEGFAVDATSASCPIAAMSNEAKKFYAVQFHPEVRHSVYGNDILRNFVFDVCQCKGDWTMGSFIDSEVRKIRELVGDKKVLCALSGGVDSSVAAVLVHRAIGDQLTCIFVDHGLLRKGEAESVMKTFREGFQMNVIKVDAKERFLSKLKGVIDPEQKRKIIGNEFIYVFDDEAAKLEGIEFLVQGTLYTDIIESGTATAQTIKSHHNVGGLPEDMKFKLIEPLKTLFKDEVRALGTELGLPDEIVWRQPFPGPGLGIRVLGEVTEEKLEIVRESDAILREEIKKAGLDREIWQYFTVLPDIRSVGVMGDARTYDYTVGIRAVTSVDGMTADWARIPWEVLEKISTRIVNEVPHVNRVVYDITSKPPATIEWE
>NC_014650.1|WP_013401762.1|3548006_3550169_-|DUF4129-domain-containing-protein
MMEAAKPIGRRMLIYGFACWLLIEWLLPLETASDTRNTEVFIAFVAVCFLFYLLRTPIWISAPIKMAYIIYALNSLFYHVSYVQAWKLLFQEIAHHAPMLFTARWMEWTNSFRSFLFFFLLWLMAYLLHYLLRTQKRLFLFYVLTVIYITVLDTFTAFRGNGAVIRLVVFGFFFLSFLHMERLQEKAKIAGRIREWWGACLCLIGLAIACGYVSPKLPPQWPDPVAFVKSYAAVQEEKQNDPALAKVKKIGYGQNDSRLGGPFIADDTVVFIAEDEKRHYWRVETKDIYTGKGWESFRSEQIQSFENNADLGYSWWSPEVEKQLTDASIRMKQSYFHIVYPLGLKKVNAKEDVVYRMEAATEKIYATDRSAYTLSLASYDIVYEYPTFPIEALKAAPPVKDASLLKRYTQLPENLPERVRNLAKQIISGKPTQYEQVKAIEQYFHMNGYMYETTDVAVPGKNEDYVDQFLFKTKKGYCDNFSTSMVVMLRSVGIPARWVKGYTPGRLLEEKNGKYVYEITNNDAHSWVEVYFSGIGWVPFEPTQGFTNPYVFAASQSAPETASLPNLRQPEQNRVPLDEVREQPHSVSAKEASLPAWSWKQAVVALAVLFAFAWIAYRTRRKWWPYATIVRFQYKRKKGDHPFAEAYLSLLRHLDDYGLKRNQGQTLRQYAAYVDDWFQTNEMTKLTLLYEKTIYQQETARVEWTEVKELWENLIKKTVS

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Crispr_ID: NC_014650_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014650_14

3757310-3757403

Orphan

Consensus_repeat	Method
GAAAACAAGACAGGGCTTCCGGCTCCGAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014650_14

>merge|NC_014650|14|3757310-3757403|CRISPRCasFinder
GAAAACAAGACAGGGCTTCCGGCTCCGACCTCATCTGTTTCGCCTTCTTGTTTAATCTCATCCAAGAAAACAAGACAGGGTTTCCGGCTCCGAC

>NC_014650|14|14|3757310-3757403|CRISPRCasFinder
GAAAACAAGACAGGGCTTCCGGCTCCGAC	CTCATCTGTTTCGCCTTCTTGTTTAATCTCATCCAA
GAAAACAAGACAGGGTTTCCGGCTCCGAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_014650.1\|WP_013401868.1\|3756961_3757225_-\|YwdI-family-protein	unknown	unknown	gnl\|CDD\|379956
NC_014650.1\|WP_003253756.1\|3753211_3754186_-\|phosphate-acetyltransferase	unknown	unknown	gnl\|CDD\|236609
NC_014650.1\|WP_013401875.1\|3763758_3765378_-\|M20/M25/M40-family-metallo-hydrolase	unknown	unknown	gnl\|CDD\|349905
NC_014650.1\|WP_013401863.1\|3749575_3750877_-\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|224004
NC_014650.1\|WP_013401864.1\|3751600_3752260_+\|RsfA-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|274342
NC_014650.1\|WP_003253753.1\|3751024_3751252_-\|DUF1450-domain-containing-protein	unknown	unknown	gnl\|CDD\|377806
NC_014650.1\|WP_003253760.1\|3756428_3756800_-\|DUF423-domain-containing-protein	unknown	unknown	gnl\|CDD\|225238
NC_014650.1\|WP_003253757.1\|3754390_3755137_+\|heme-dependent-peroxidase	unknown	unknown	gnl\|CDD\|237033
NC_014650.1\|WP_013401865.1\|3752293_3753130_-\|lipoate--protein-ligase-family-protein	unknown	unknown	gnl\|CDD\|319742
NC_014650.1\|WP_013401870.1\|3758931_3760314_-\|glycine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235240
NC_014650.1\|WP_185948744.1\|3760620_3761445_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|366154
NC_014650.1\|WP_003253758.1\|3755362_3755785_+\|cell-wall-hydrolase	unknown	unknown	gnl\|CDD\|226296
NC_014650.1\|WP_003253762.1\|3757417_3758092_-\|uracil-DNA-glycosylase	unknown	unknown	gnl\|CDD\|235376
NC_014650.1\|WP_013401877.1\|3768497_3769328_-\|PRD-domain-containing-protein	unknown	unknown	gnl\|CDD\|170086
NC_014650.1\|WP_013401873.1\|3762830_3763166_-\|DUF3147-family-protein	unknown	unknown	gnl\|CDD\|181745
NC_014650.1\|WP_013401872.1\|3761533_3762730_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340874
NC_014650.1\|WP_013401874.1\|3763153_3763579_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224759
NC_014650.1\|WP_013401876.1\|3766939_3768313_-\|PTS-sucrose-transporter-subunit-IIBC	unknown	unknown	gnl\|CDD\|131051
NC_014650.1\|WP_013401867.1\|3755811_3756330_+\|spore-coat-protein-GerQ	unknown	unknown	gnl\|CDD\|370609
NC_014650.1\|WP_003253770.1\|3765456_3766899_-\|sucrose-6-phosphate-hydrolase	unknown	unknown	gnl\|CDD\|273554

Protein	Function_ID	Function_description	E-value
NC_014650.1\|WP_013401868.1\|3756961_3757225_-\|YwdI-family-protein	gnl\|CDD\|379956	pfam17261, DUF5327, Family of unknown function (DUF5327). This bacterial family of proteins has no known function and is mostly found in Bacilli.	1.29539e-25
NC_014650.1\|WP_003253756.1\|3753211_3754186_-\|phosphate-acetyltransferase	gnl\|CDD\|236609	PRK09653, eutD, phosphotransacetylase.	0
NC_014650.1\|WP_013401875.1\|3763758_3765378_-\|M20/M25/M40-family-metallo-hydrolase	gnl\|CDD\|349905	cd05654, M20_ArgE_RocB, M20 Peptidase arginine utilization protein, RocB. Peptidase M20 family, ArgE RocB (arginine utilization protein, RocB; arginine degradation protein, RocB) subfamily. This group of proteins is possibly related to acetylornithine deacetylase (ArgE) and may be involved in the arginine and/or ornithine degradation pathway. In Bacillus subtilis, RocB is one of the three genes found in the rocABC operon, which is sigma L dependent and induced by arginine. The function of members of this family is as yet unknown, although they are predicted as deacetylases.	0
NC_014650.1\|WP_013401863.1\|3749575_3750877_-\|HD-domain-containing-protein	gnl\|CDD\|224004	COG1078, COG1078, HD superfamily phosphohydrolases [General function prediction only].	2.22308e-158
NC_014650.1\|WP_013401864.1\|3751600_3752260_+\|RsfA-family-transcriptional-regulator	gnl\|CDD\|274342	TIGR02894, DNA_bind_RsfA, transcription factor, RsfA family. In a subset of endospore-forming members of the Firmcutes, members of this protein family are found, several to a genome. Two very strongly conserved sequences regions are separated by a highly variable linker region. Much of the linker region was excised from the seed alignment for this model. A characterized member is the prespore-specific transcription RsfA from Bacillus subtilis, previously called YwfN, which is controlled by sigma factor F and seems to fine-tune expression of some genes in the sigma-F regulon. A paralog in Bacillus subtilis is designated YlbO. [Regulatory functions, DNA interactions, Cellular processes, Sporulation and germination].	1.31834e-59
NC_014650.1\|WP_003253753.1\|3751024_3751252_-\|DUF1450-domain-containing-protein	gnl\|CDD\|377806	pfam07293, DUF1450, Protein of unknown function (DUF1450). This family consists of several hypothetical bacterial proteins of around 80 residues in length. Members of this family contain four highly conserved cysteine residues. The function of this family is unknown.	1.18786e-07
NC_014650.1\|WP_003253760.1\|3756428_3756800_-\|DUF423-domain-containing-protein	gnl\|CDD\|225238	COG2363, COG2363, Uncharacterized small membrane protein [Function unknown].	5.78299e-37
NC_014650.1\|WP_003253757.1\|3754390_3755137_+\|heme-dependent-peroxidase	gnl\|CDD\|237033	PRK12276, PRK12276, putative heme peroxidase; Provisional.	0
NC_014650.1\|WP_013401865.1\|3752293_3753130_-\|lipoate--protein-ligase-family-protein	gnl\|CDD\|319742	cd16443, LplA, lipoate-protein ligase. Lipoate-protein ligase A (LplA) catalyzes the formation of an amide linkage between free lipoic acid and a specific lysine residue of the lipoyl domain in lipoate dependent enzymes, similar to the biotinylation reaction mediated by biotinyl protein ligase (BPL). The two step reaction includes activation of exogenously supplied lipoic acid at the expense of ATP to lipoyl-AMP and then transfer to the epsilon-amino group of a specific lysine residue of the lipoyl domain of the target protein.	8.40675e-51
NC_014650.1\|WP_013401870.1\|3758931_3760314_-\|glycine--tRNA-ligase	gnl\|CDD\|235240	PRK04173, PRK04173, glycyl-tRNA synthetase; Provisional.	0
NC_014650.1\|WP_185948744.1\|3760620_3761445_-\|glycosyltransferase	gnl\|CDD\|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	2.08065e-27
NC_014650.1\|WP_003253758.1\|3755362_3755785_+\|cell-wall-hydrolase	gnl\|CDD\|226296	COG3773, SleB, Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane].	4.17906e-35
NC_014650.1\|WP_003253762.1\|3757417_3758092_-\|uracil-DNA-glycosylase	gnl\|CDD\|235376	PRK05254, PRK05254, uracil-DNA glycosylase; Provisional.	9.20211e-156
NC_014650.1\|WP_013401877.1\|3768497_3769328_-\|PRD-domain-containing-protein	gnl\|CDD\|170086	PRK09772, PRK09772, transcriptional antiterminator BglG; Provisional.	2.72258e-54
NC_014650.1\|WP_013401873.1\|3762830_3763166_-\|DUF3147-family-protein	gnl\|CDD\|181745	PRK09272, PRK09272, hypothetical protein; Provisional.	2.05755e-31
NC_014650.1\|WP_013401872.1\|3761533_3762730_-\|MFS-transporter	gnl\|CDD\|340874	cd17316, MFS_SV2_like, Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily. This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	4.53477e-73
NC_014650.1\|WP_013401874.1\|3763153_3763579_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|224759	COG1846, MarR, Transcriptional regulators [Transcription].	4.84859e-15
NC_014650.1\|WP_013401876.1\|3766939_3768313_-\|PTS-sucrose-transporter-subunit-IIBC	gnl\|CDD\|131051	TIGR01996, Includes:_Phosphotransferase_enzyme_IIB_component, PTS system, sucrose-specific IIBC component. This model represents the fused enzyme II B and C components of the sucrose-specific PTS sugar transporter system. Sucrose is converted to sucrose-6-phosphate in the process of translocation into the cell. Some of these transporters lack their own IIA domains and instead use the glucose IIA protein (IIAglc or Crr). The exceptions to this rule are Staphylococci, Streptococci, Lactococci, Lactobacilli, etc. which contain their own A domain as a C-terminal fusion. This family is closely related to the trehalose transporting PTS IIBC enzymes and the B and C domains of each are described by subfamily-domain level TIGRFAMs models (TIGR00826 and TIGR00852, respectively).	0
NC_014650.1\|WP_013401867.1\|3755811_3756330_+\|spore-coat-protein-GerQ	gnl\|CDD\|370609	pfam09671, Spore_GerQ, Spore coat protein (Spore_GerQ). Members of this protein family are the spore coat protein GerQ of endospore-forming Firmicutes (low GC Gram-positive bacteria). This protein is cross-linked by a spore coat-associated transglutaminase.	1.47477e-50
NC_014650.1\|WP_003253770.1\|3765456_3766899_-\|sucrose-6-phosphate-hydrolase	gnl\|CDD\|273554	TIGR01322, Sucrose-6-phosphate_hydrolase, sucrose-6-phosphate hydrolase. [Energy metabolism, Biosynthesis and degradation of polysaccharides].	0

>NC_014650.1|WP_013401868.1|3756961_3757225_-|YwdI-family-protein
MLNIPIAAILTKMEEQLRQAKTAASQQRLREHIAAVRALCDLVLEKEEAKETAAVSSAAVVPLSIPQGKSERIDIGDDANGPSLFDF
>NC_014650.1|WP_003253760.1|3756428_3756800_-|DUF423-domain-containing-protein
MKTFVLLGAINAFLSVALGAFGAHGLEGKIPGHYLEVWKTGVQYQMFHALGLLAVGLLLGKFPNVGLLTTAGWIMFIGIVLFSGSLYVLSVTQIKPLGMITPFGGVSFLIAWALIGYAAVKAL
>NC_014650.1|WP_013401867.1|3755811_3756330_+|spore-coat-protein-GerQ
MSANSYENTFLEDERQQPYFYYPYLYGGYMFPQAYYPTAYPYSQQPLTAAAPAFGTQAPSFAVQTPTTAIQPSIPGMLPIEQSYIENILRLNKGKTATVYMTFENNREWNAKIFRGIIEAAGRDHLILSEPQTGRRYLLPMIYLDYIVFEGEIAYEYPFAGATAELSTYSPR
>NC_014650.1|WP_003253758.1|3755362_3755785_+|cell-wall-hydrolase
MAVVACTDEEVRLLARLMRAEAEGDGKLGMLMVGNVGVNRCIADCLDFRGIRTIRQMVFQSPGGFEAVRKGYFYQRARDTDIQLARQVIRGWRYHPATNSLWFFKPAGECPPQWFNQWNAGRYKSHCFYAPSQSDCPRVY
>NC_014650.1|WP_003253757.1|3754390_3755137_+|heme-dependent-peroxidase
MSEAAQTLDGWYCLHDFRSVDWSAWKTLTSDEREAAIHEFLSLVQKWQETEDKQEGSHAIYTIVGQKADIMFMILRPTIEELNEIETALNKTKLAEYLVPTYSYVSVVELSNYLASGNEDPYQIPEVRRRLYPILPKTKHVCFYPMDKRRQGNDNWYMLSIEERRNLMRAHGMTGRKYAGKVTQIITGSIGLDDFEWGVTLFSDDALQFKKLVYEMRFDEVSARYGEFGSFFVGNRLTVEKVPLFFHV
>NC_014650.1|WP_003253756.1|3753211_3754186_-|phosphate-acetyltransferase
MSSDLFSTLKEKIAGKQRKIVFPEGLDERILTAVSRLANEQIVTPIVIGNEEAVKQKASELGLTLPNVEIIDPHQYGEMDKLVAAFVERRKGKVTEEAARKLLLDENYFGTMLVYMDKAHGLVSGAAHSTADTVRPALQIIKTKQGVRKTSGVFIMVRGDEKYVFADCAINIAPDSQDLAEIAVESANTAKMFDIEPRVAMLSFSTKGSAKSPETEKVVEAVRLAKEMAPDLVLDGEFQFDAAFVPSVAKKKAPDSVIQGDANVFIFPSLEAGNIGYKIAQRLGNFEAVGPILQGLNKPVNDLSRGCNAEDVYKLTLITAAQSL
>NC_014650.1|WP_013401865.1|3752293_3753130_-|lipoate--protein-ligase-family-protein
MVHELLQQAKWRIIDQSHFGPMFDAKQSFAIDDTLCTSVGKGLSDPVVRTWVHYNTVVLGIQDTKLPHLRDAVSFLKAQKYNVIVRNSGGLAVVLDDGVLNLSLIFPETTKVIDINQGYEAMWQLVQAMFSDYNKAIEAREITGSYCPGSYDLSIAGKKFAGISQRRVRGGVAVQIYLCINGSGSARAELLRRFYKIGLKGEKTKFTYPMIVPSTMASLSELLHEELTISSVLLLLFRTLQSFGGKLYSSALNGEELSLYEYYWERIVNRNEKSLIAQ
>NC_014650.1|WP_013401864.1|3751600_3752260_+|RsfA-family-transcriptional-regulator
MKQRQDAWTEEDDLLLAETVLRHVREGSTQLNAFEEVGDKLNRTSAACGFRWNAVVRRRYEQALQLAKRQRKERQRLLGKQQAVRKKRLYNPPVPSLEEIGEIVQLPAVVPSTNETSPMTLDHVITFLQTFKTVHRDHESLVKENERLRKENEEIRAKNNELEKKIAKLEENSSTIQEDYETLVRIINRARKLVLQEEEERQALKFRMDQNGNLEKIAE
>NC_014650.1|WP_003253753.1|3751024_3751252_-|DUF1450-domain-containing-protein
MANEFRVCADCKAPNLKTLIPRLKKLDPNATIKIGCQSYCGPGRKKTFAFVNNRPVSALTEDELIEKIAEKLKKS
>NC_014650.1|WP_013401863.1|3749575_3750877_-|HD-domain-containing-protein
MAYPGGQLSEEKVFKDPVHRYIHVRDKVIWDLIGTKEFQRLRRIKQLGTTYLTFHGAEHSRFNHSLGVYEIIRRIIDDVFVGREHWDHSERLLCLCAALLHDLGHGPFSHSFEKVFRLDHEDFTQAIILGDTEVNKVLRRVSADFPKKVAEVIAKTYPNKLVVSLISSQIDADRMDYLLRDAYYTGVSYGNFDMERILRVMRPREDQVVIKRSGMHAVEDYIMSRYQMYWQVYFHPVTRSAEVILTKILHRAKKLYEDGYNFQTKPVHFYSLFAGNVDLQDYLKLDEAVILFYFQQWQDERDEILSDLCRRFVNRHLFKYVEFNPTNEQMTKLIELTSLFKKADIDPEYYLVVDSSSDLPYDFYRPGEEGERLPIYLLMPNGELRELSRESVLVDAISGKRRTDHKLYFPADFIYDFSTKRTTKKKIIEILEG
>NC_014650.1|WP_003253762.1|3757417_3758092_-|uracil-DNA-glycosylase
MAILKNDWAPLLEEEFRKPYYIKLREFLKEEYRTRTIYPDMYDIFNALHYTPYSQVKVVILGQDPYHGPGQAHGLSFSVKPGVPLPPSLVNIFKELHDDLGCYIPNNGYLVKWAKQGVLLLNTVLTVRRGQANSHKGKGWEFFTDRVIELVNEKQDPVVFLLWGRHAQAKKELITNPHHYIIEAPHPSPFSAARGFFGHRPFSRANAFLQKVGREPIDWQIENI
>NC_014650.1|WP_013401870.1|3758931_3760314_-|glycine--tRNA-ligase
MSVTMEQIVAHAKHRGFVFPGSEIYGGLANTWDYGPLGTELKNNIKRAWWKKFVQESPYNVGLDAAILMNPKTWEASGHLGNFNDPMIDCKQCKARHRADKLIESALEEKGIEIVVDGLPFEKMEELIKEHNIACPECGSHDFTNIRQFNLMFKTYQGVTESSANEIYLRPETAQGIFVNFKNVQRTMRKKLPFGIAQIGKSFRNEITPGNFTFRTREFEQMELEFFCKPGEELKWFDYWKQFCKQWLLSLGMKEENIRLRDHTKEELSHYSNATTDIEYKFPFGWGELWGIASRTDYDLKQHMEYSGEDFRYIDQETNERYIPYCIEPSLGADRVTLAFMIDAYDEEELEDGTTRTVMRLHPALAPYKAAVFPLSKKLAEGARNIFADLSKHFMVDYDETGSIGKRYRRQDEIGTPFCITYDFDSEQDGMVTVRDRDTMEQVRIPISQLKSFLEEKVQF
>NC_014650.1|WP_185948744.1|3760620_3761445_-|glycosyltransferase
MNSFVSVVIPTYNRPYPLAELLESLNRQTYHHFEVIIVNDGGERVDDIIALYPELDVHLIHCRGNVGHVEARNIGVKAAKGELIMLCDDDDLLLPCHMEQMVAEISDVDFVYSDVEIFHYRTENGQRIPTDRFLFAYEYDREAMRKFSTYVPSGSLYRKLIHDHIGYFDPGVHHYWDWDFFLRVSGSFRVKRVATASVLYAFSDAGNNLSRRMDDKRRMYLNRLSEKHGLGNLPMKNFWLLLDEPEVKKRRAESKIVWDGEPIISRLWHLKHHL
>NC_014650.1|WP_013401872.1|3761533_3762730_-|MFS-transporter
MSRQTISQRKLLGVAGLGWMFDAMDVGMLSFIIAALQKDWGLSAKQMGWIGSVNSIGMAAGALLFGLLADRIGRKNVFIITLLLFSIGSGLSALTTTLAAFLVLRFLIGMGLGGELPVASTLVSESVPAHERGKAVVLLESFWAVGWLLSAFISYFVIPTYGWQTALLLATIPALYALYLRWGLPDSPRFTSAHKEKTVWNNIAKVWSSAYRKETFMLWVLWFCVVFSYYGMFLWLPSVMVMKGFSLIKSFEYVLLMTLAQLPGYFSAAWLIERMGRKFVLITYLIGTAVSAYFFGNADSLALLMTSGILLSFFNLGAWGALYAYTPELYPTSVRGTGAGMAAAFGRIGGVLGPLFVGYFVGNGLTVTAIFAVFCLSIFVGVIAVWALGKETKQRELA
>NC_014650.1|WP_013401873.1|3762830_3763166_-|DUF3147-family-protein
MFALVKIVVSAIIIGGVTEAARRYPAFGGVIAALPLVSLLSLFWLYFQGEEIRILSKFIDGVLWGLPATAFLLFVIGLCFKASFPFSLSVALGIVGWGMFLMIQNILFKNM
>NC_014650.1|WP_013401874.1|3763153_3763579_-|MarR-family-transcriptional-regulator
MQIDDVIEMINEQWTDIYYLLHYVHEDHITHQAVRLLQYIEKNKEATIGDLAKHLAVSHNTASEHIKRLIKKGLVVKRRSSVDERKVFVVLTEEGRRVLYRHTRLDKDKLKKIFKQMDPSDIELIQKAFSILSEGARKCLR
>NC_014650.1|WP_013401875.1|3763758_3765378_-|M20/M25/M40-family-metallo-hydrolase
MKWQTPQQLKQLLCRLVEYPSISGTEAEISIAKFIAEQLRAIDYFRGNNEFVQLHPTGDGRYFVTALVKKAEQVRDTVVLISHFDVVDVQDYGMWKDAAFSPEELTKRFYEQKQQLPSSVQADLEKGEWLFGRGVMDMKCGLALHMSLIEQACHGAFAGNLLLLTVPDEEANSVGMRAAAPVLVEMAEKYELTYRLVINSEPMFARYPGDKTNYIYTGSIGKALPGFYCYGKETHVGEPFAGLNANFMVAQIASELELNTDFCEVFDGEASPPPTSLLQTDLKEEYSVQIPHRAVALFNLFLQQKPLDDVTDSLIAAAKRAAKRIEKHYDSEASRFAKFETSVPKPILINVFTFAELRKKAVDMFGSKKVEQLEASVLSMEAAKDDREKTIALVDRLAMLCKDFAPMIVLFYAPPYYPAVSSGSDPFVQRLVAKLQKYAQEKHGILLVRQHYFPGISDLSYVGLQQSFASLQTLTENMPIWDCGYQLPLDALAKWDVPMLNIGPIGRDAHQWTERLNVRFAFKELKEWLEYIVGETFVK
>NC_014650.1|WP_003253770.1|3765456_3766899_-|sucrose-6-phosphate-hydrolase
MKSEKEQQLIEQAYAEMKKYRDMVEKDYYRLHYHLMPPVGLMNDPNGLIHWNGVYHVFYQWMPFHTGHGAKFWGHYTSCDLVHWKQEKIALAPSEWFDKNGCYSGSAIDNDGVLTLFYTGNVKDEYGNRQTYQCMAMSKNGIDFEKKGVVVTLPDGYTAHFRDPKVWKKDKNWYMIVGAQSNSLDGRAVLFRSKNLFDWEYLGAIAGGNLNQLGDFGYMWECPDLFELDGQEVLLVCPQGLKAEGMKYHNVHQSGYFVGCLDYETAQFFHGAFTELDRGFEFYAPQTMLDEKGRRILIAWMGVPDQDEDKHPTVAHRWVHALTLPRELKLKDGKIYQKPVEELQMLRKDKIAYSGVTIANEEIMLEGINGDVIELYLENIHLLGDMEIVIRSEVRLIYNSGERVLTLERKSFANGLTEKRQCYLEYLHSLHMFLDTSSIEVFVNGGEEVFTARFFPHKNNQTISFAANGQLVFDIEKWSL
>NC_014650.1|WP_013401876.1|3766939_3768313_-|PTS-sucrose-transporter-subunit-IIBC
MNYEHIAKQLISLLGGKENLISAAHCATRLRLVLKDDKKADTKAIESIEGVKGAFSSSGQYQIIFGTGVVNKVYDAFVKEAGLQHISTAVHQEAIKQKMNPLARLAKTLSNIFVPIIPAIVASGLLMGLLGMMKAFKWVAPDSPWYVLLDMFSSAAFIILPILIGFSAAKEFGGTPFLGAVIGGIMTHPALLNPWGLAEAKPEYMHFLGFDIAMVGYQGTVIPILLATYVMCKIERGLRKIVPHAVSLLVVPFVTVIFTGFITILAIGPLGNLLGDGITTVLNFIYHYGGALAGLVFGGLYSMIVITGVHHSFHAIEANLLAKLGVNYLLPIWSMANIAQGGAGLAVFVKAKRAKTKEVALPSALSAFLGITEPVIFGVNLKYRKPFIAAAIGGALGGAYVVFTNVVANAYGLTGIPMIAIVAPEGMQNLVNYLVGFAIAVVSAFIATLLLGFREEE
>NC_014650.1|WP_013401877.1|3768497_3769328_-|PRD-domain-containing-protein
MAFRIHKILNNNAVVVLDDGKEKIVMGAGIAFQKRKNDIIPPSKIEKIFVMKGENEKFQQLLRTLPEEHIEIAEEIISYAEGQLQAPLNNHIHIALTDHLSFALERLEQGYRIQNKLLNEIKVLYRKEYQIGLWAKQLIKERLCIEIPDDEVAHIALHIHTAKMDAASMNKTLRQTTLIREMVDIVQAELGVDMDEESISYQRLLTHLRFAINRIEDHEWFHSMDDEMLALIQAKYEKEYACAKKIAEHAKSEYGLEFPDAELAYIALHLQRLQKR

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_014650_14	14.1\|3757339\|36\|NC_014650\|CRISPRCasFinder	3757339-3757374	36	NC_014650.1	2785690-2785725	0	1.0
NC_014650_1	1.1\|92946\|57\|NC_014650\|CRISPRCasFinder	92946-93002	57	NC_014650.1	12581-12637	1	0.982
NC_014650_1	1.1\|92946\|57\|NC_014650\|CRISPRCasFinder	92946-93002	57	NC_014650.1	32683-32739	1	0.982
NC_014650_1	1.1\|92946\|57\|NC_014650\|CRISPRCasFinder	92946-93002	57	NC_014650.1	160782-160838	1	0.982
NC_014650_1	1.1\|92946\|57\|NC_014650\|CRISPRCasFinder	92946-93002	57	NC_014650.1	3271759-3271815	1	0.982
NC_014650_13	13.1\|3536474\|57\|NC_014650\|CRISPRCasFinder	3536474-3536530	57	NC_014650.1	12581-12637	1	0.982
NC_014650_13	13.1\|3536474\|57\|NC_014650\|CRISPRCasFinder	3536474-3536530	57	NC_014650.1	32683-32739	1	0.982
NC_014650_13	13.1\|3536474\|57\|NC_014650\|CRISPRCasFinder	3536474-3536530	57	NC_014650.1	160782-160838	1	0.982
NC_014650_13	13.1\|3536474\|57\|NC_014650\|CRISPRCasFinder	3536474-3536530	57	NC_014650.1	3271759-3271815	1	0.982
NC_014650_1	1.1\|92946\|57\|NC_014650\|CRISPRCasFinder	92946-93002	57	NC_014650.1	99063-99119	2	0.965
NC_014650_13	13.1\|3536474\|57\|NC_014650\|CRISPRCasFinder	3536474-3536530	57	NC_014650.1	99063-99119	2	0.965

1. spacer 14.1|3757339|36|NC_014650|CRISPRCasFinder matches to position: 2785690-2785725, mismatch: 0, identity: 1.0

ctcatctgtttcgccttcttgtttaatctcatccaa	CRISPR spacer
ctcatctgtttcgccttcttgtttaatctcatccaa	Protospacer
************************************

2. spacer 1.1|92946|57|NC_014650|CRISPRCasFinder matches to position: 12581-12637, mismatch: 1, identity: 0.982

tgaatgcaaagaagttggattcctcgacgcaagacagcaaagaagtgagcacaaggt	CRISPR spacer
tgaatgcaaagaagctggattcctcgacgcaagacagcaaagaagtgagcacaaggt	Protospacer
**************.******************************************

3. spacer 1.1|92946|57|NC_014650|CRISPRCasFinder matches to position: 32683-32739, mismatch: 1, identity: 0.982

tgaatgcaaagaagttggattcctcgacgcaagacagcaaagaagtgagcacaaggt	CRISPR spacer
tgaatgcaaagaagctggattcctcgacgcaagacagcaaagaagtgagcacaaggt	Protospacer
**************.******************************************

4. spacer 1.1|92946|57|NC_014650|CRISPRCasFinder matches to position: 160782-160838, mismatch: 1, identity: 0.982

tgaatgcaaagaagttggattcctcgacgcaagacagcaaagaagtgagcacaaggt	CRISPR spacer
tgaatgcaaagaagctggattcctcgacgcaagacagcaaagaagtgagcacaaggt	Protospacer
**************.******************************************

5. spacer 1.1|92946|57|NC_014650|CRISPRCasFinder matches to position: 3271759-3271815, mismatch: 1, identity: 0.982

tgaatgcaaagaagttggattcctcgacgcaagacagcaaagaagtgagcacaaggt	CRISPR spacer
tgaatgcaaagaagctggattcctcgacgcaagacagcaaagaagtgagcacaaggt	Protospacer
**************.******************************************

6. spacer 13.1|3536474|57|NC_014650|CRISPRCasFinder matches to position: 12581-12637, mismatch: 1, identity: 0.982

accttgtgctcacttctttgctgtcttgcgtcgaggaatccaacttctttgcattca	CRISPR spacer
accttgtgctcacttctttgctgtcttgcgtcgaggaatccagcttctttgcattca	Protospacer
******************************************.**************

7. spacer 13.1|3536474|57|NC_014650|CRISPRCasFinder matches to position: 32683-32739, mismatch: 1, identity: 0.982

accttgtgctcacttctttgctgtcttgcgtcgaggaatccaacttctttgcattca	CRISPR spacer
accttgtgctcacttctttgctgtcttgcgtcgaggaatccagcttctttgcattca	Protospacer
******************************************.**************

8. spacer 13.1|3536474|57|NC_014650|CRISPRCasFinder matches to position: 160782-160838, mismatch: 1, identity: 0.982

accttgtgctcacttctttgctgtcttgcgtcgaggaatccaacttctttgcattca	CRISPR spacer
accttgtgctcacttctttgctgtcttgcgtcgaggaatccagcttctttgcattca	Protospacer
******************************************.**************

9. spacer 13.1|3536474|57|NC_014650|CRISPRCasFinder matches to position: 3271759-3271815, mismatch: 1, identity: 0.982

accttgtgctcacttctttgctgtcttgcgtcgaggaatccaacttctttgcattca	CRISPR spacer
accttgtgctcacttctttgctgtcttgcgtcgaggaatccagcttctttgcattca	Protospacer
******************************************.**************

10. spacer 1.1|92946|57|NC_014650|CRISPRCasFinder matches to position: 99063-99119, mismatch: 2, identity: 0.965

tgaatgcaaagaagttggattcctcgacgcaagacagcaaagaagtgagcacaaggt	CRISPR spacer
tgaatgcaaagaagctggattcctcgacgcaagacagcaaagaagtgagcacaaagt	Protospacer
**************.***************************************.**

11. spacer 13.1|3536474|57|NC_014650|CRISPRCasFinder matches to position: 99063-99119, mismatch: 2, identity: 0.965

accttgtgctcacttctttgctgtcttgcgtcgaggaatccaacttctttgcattca	CRISPR spacer
actttgtgctcacttctttgctgtcttgcgtcgaggaatccagcttctttgcattca	Protospacer
**.***************************************.**************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_014650_12	12.4\|3431690\|35\|NC_014650\|CRISPRCasFinder,CRT,PILER-CR	3431690-3431724	35	NC_029073	Geobacillus virus E3, complete genome	79104-79138	1	0.971
NC_014650_7	7.4\|1450444\|37\|NC_014650\|CRISPRCasFinder,CRT	1450444-1450480	37	NC_019544	Deep-sea thermophilic phage D6E, complete genome	3345-3381	2	0.946
NC_014650_7	7.7\|1450642\|36\|NC_014650\|CRISPRCasFinder,CRT,PILER-CR	1450642-1450677	36	NC_019544	Deep-sea thermophilic phage D6E, complete genome	38968-39003	2	0.944
NC_014650_7	7.11\|1450902\|37\|NC_014650\|CRISPRCasFinder,CRT,PILER-CR	1450902-1450938	37	NC_002062	Geobacillus stearothermophilus plasmid pSTK1 DNA, complete sequence	1008-1044	2	0.946
NC_014650_9	9.13\|1955073\|36\|NC_014650\|CRISPRCasFinder,CRT,PILER-CR	1955073-1955108	36	NC_029073	Geobacillus virus E3, complete genome	53190-53225	3	0.917
NC_014650_7	7.11\|1450902\|37\|NC_014650\|CRISPRCasFinder,CRT,PILER-CR	1450902-1450938	37	NZ_CP019654	Paenibacillus larvae subsp. larvae DSM 25430 plasmid unnamed2, complete sequence	2281-2317	6	0.838
NC_014650_7	7.11\|1450902\|37\|NC_014650\|CRISPRCasFinder,CRT,PILER-CR	1450902-1450938	37	NC_023147	Paenibacillus larvae subsp. larvae DSM 25430 plasmid pPLA2_10, complete sequence	263-299	6	0.838
NC_014650_7	7.22\|1451618\|39\|NC_014650\|CRISPRCasFinder,CRT,PILER-CR	1451618-1451656	39	NC_019544	Deep-sea thermophilic phage D6E, complete genome	2334-2372	6	0.846
NC_014650_4	4.16\|591679\|35\|NC_014650\|CRISPRCasFinder,CRT,PILER-CR	591679-591713	35	NC_018265	Melissococcus plutonius DAT561 plasmid 1, complete sequence	14266-14300	7	0.8
NC_014650_12	12.13\|3432289\|37\|NC_014650\|CRISPRCasFinder,CRT,PILER-CR	3432289-3432325	37	MF595878	Caldibacillus phage CBP1, complete genome	9865-9901	7	0.811
NC_014650_4	4.16\|591679\|35\|NC_014650\|CRISPRCasFinder,CRT,PILER-CR	591679-591713	35	NC_010371	Finegoldia magna ATCC 29328 plasmid pFMC, complete sequence	54028-54062	8	0.771
NC_014650_7	7.17\|1451291\|34\|NC_014650\|CRISPRCasFinder,CRT,PILER-CR	1451291-1451324	34	MT701590	Klebsiella phage Miami, complete genome	76771-76804	8	0.765
NC_014650_14	14.1\|3757339\|36\|NC_014650\|CRISPRCasFinder	3757339-3757374	36	MG065689	UNVERIFIED: Campylobacter phage A110a, complete genome	59701-59736	8	0.778
NC_014650_14	14.1\|3757339\|36\|NC_014650\|CRISPRCasFinder	3757339-3757374	36	MT932211	Escherichia phage VEcB, complete genome	111145-111180	8	0.778
NC_014650_14	14.1\|3757339\|36\|NC_014650\|CRISPRCasFinder	3757339-3757374	36	MN850601	Escherichia phage inny, complete genome	101293-101328	8	0.778
NC_014650_14	14.1\|3757339\|36\|NC_014650\|CRISPRCasFinder	3757339-3757374	36	KU522583	Enterobacteria phage ECGD1, complete genome	121268-121303	8	0.778
NC_014650_14	14.1\|3757339\|36\|NC_014650\|CRISPRCasFinder	3757339-3757374	36	MN850645	Escherichia phage outra, complete genome	76729-76764	8	0.778
NC_014650_14	14.1\|3757339\|36\|NC_014650\|CRISPRCasFinder	3757339-3757374	36	MN850584	Escherichia phage arall, complete genome	40765-40800	8	0.778
NC_014650_14	14.1\|3757339\|36\|NC_014650\|CRISPRCasFinder	3757339-3757374	36	MH675927	Escherichia phage vB_vPM_PD114, complete genome	114085-114120	8	0.778
NC_014650_14	14.1\|3757339\|36\|NC_014650\|CRISPRCasFinder	3757339-3757374	36	FR775895	Enterobacteria phage phi92, complete genome	112129-112164	8	0.778
NC_014650_14	14.1\|3757339\|36\|NC_014650\|CRISPRCasFinder	3757339-3757374	36	MG065645	UNVERIFIED: Campylobacter phage A145, complete genome	20293-20328	8	0.778
NC_014650_14	14.1\|3757339\|36\|NC_014650\|CRISPRCasFinder	3757339-3757374	36	MN850632	Escherichia phage alia, complete genome	53456-53491	8	0.778
NC_014650_14	14.1\|3757339\|36\|NC_014650\|CRISPRCasFinder	3757339-3757374	36	MN850573	Escherichia phage muut, complete genome	100643-100678	8	0.778
NC_014650_14	14.1\|3757339\|36\|NC_014650\|CRISPRCasFinder	3757339-3757374	36	MG065639	UNVERIFIED: Campylobacter phage A150, complete genome	76895-76930	8	0.778
NC_014650_14	14.1\|3757339\|36\|NC_014650\|CRISPRCasFinder	3757339-3757374	36	MG065656	UNVERIFIED: Campylobacter phage C3, complete genome	32187-32222	8	0.778
NC_014650_14	14.1\|3757339\|36\|NC_014650\|CRISPRCasFinder	3757339-3757374	36	MH816848	Escherichia phage vB_vPM_PD06, complete genome	37450-37485	8	0.778
NC_014650_7	7.17\|1451291\|34\|NC_014650\|CRISPRCasFinder,CRT,PILER-CR	1451291-1451324	34	HQ615693	Synechococcus phage S-CRM01, complete genome	114718-114751	9	0.735
NC_014650_9	9.3\|1954411\|35\|NC_014650\|CRISPRCasFinder,CRT	1954411-1954445	35	NC_018878	Bacillus thuringiensis Bt407 plasmid BTB_502p, complete sequence	438563-438597	9	0.743
NC_014650_12	12.7\|3431889\|35\|NC_014650\|CRISPRCasFinder,CRT,PILER-CR	3431889-3431923	35	NZ_CP039693	Agrobacterium larrymoorei strain CFBP5473 plasmid pAlCFBP5473, complete sequence	167281-167315	9	0.743
NC_014650_12	12.7\|3431889\|35\|NC_014650\|CRISPRCasFinder,CRT,PILER-CR	3431889-3431923	35	MN694222	Marine virus AFVG_250M1115, complete genome	23969-24003	10	0.714
NC_014650_12	12.7\|3431889\|35\|NC_014650\|CRISPRCasFinder,CRT,PILER-CR	3431889-3431923	35	MN694536	Marine virus AFVG_250M991, complete genome	24409-24443	10	0.714
NC_014650_12	12.7\|3431889\|35\|NC_014650\|CRISPRCasFinder,CRT,PILER-CR	3431889-3431923	35	MN693925	Marine virus AFVG_250M1114, complete genome	23771-23805	10	0.714
NC_014650_3	3.4\|263906\|35\|NC_014650\|PILER-CR,CRISPRCasFinder,CRT	263906-263940	35	MK496794	Capybara microvirus Cap3_SP_445, complete genome	2786-2820	11	0.686

1. spacer 12.4|3431690|35|NC_014650|CRISPRCasFinder,CRT,PILER-CR matches to NC_029073 (Geobacillus virus E3, complete genome) position: , mismatch: 1, identity: 0.971

gaatttggaaaatcaagagcgcaatattcagcaga	CRISPR spacer
gaatttggaaaatcaagagcgcaatactcagcaga	Protospacer
**************************.********

2. spacer 7.4|1450444|37|NC_014650|CRISPRCasFinder,CRT matches to NC_019544 (Deep-sea thermophilic phage D6E, complete genome) position: , mismatch: 2, identity: 0.946

atttccatttgcggctttcccctgtttgtgcaccacc	CRISPR spacer
atttccatttgcggctttcccctgtttgtgcgccgcc	Protospacer
*******************************.**.**

3. spacer 7.7|1450642|36|NC_014650|CRISPRCasFinder,CRT,PILER-CR matches to NC_019544 (Deep-sea thermophilic phage D6E, complete genome) position: , mismatch: 2, identity: 0.944

atgcttgtaatgcttgttcggcttttcggagtgcat	CRISPR spacer
atacttgcaatgcttgttcggcttttcggagtgcat	Protospacer
**.****.****************************

4. spacer 7.11|1450902|37|NC_014650|CRISPRCasFinder,CRT,PILER-CR matches to NC_002062 (Geobacillus stearothermophilus plasmid pSTK1 DNA, complete sequence) position: , mismatch: 2, identity: 0.946

atgacatgggaattcatgtagagatgactgggcaagg	CRISPR spacer
atgacatgggtattcatgtagagatgactggacaagg	Protospacer
********** ********************.*****

5. spacer 9.13|1955073|36|NC_014650|CRISPRCasFinder,CRT,PILER-CR matches to NC_029073 (Geobacillus virus E3, complete genome) position: , mismatch: 3, identity: 0.917

tttttcactaataaaaaagtctggataggattgttg	CRISPR spacer
cttttcactaatgaagaagtctggataggattgttg	Protospacer
.***********.**.********************

6. spacer 7.11|1450902|37|NC_014650|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP019654 (Paenibacillus larvae subsp. larvae DSM 25430 plasmid unnamed2, complete sequence) position: , mismatch: 6, identity: 0.838

atgacatgggaattcatgtagagatgactgggcaagg	CRISPR spacer
caaatatgggaattcatgttgagatgactggccaagg	Protospacer
  .*.************** *********** *****

7. spacer 7.11|1450902|37|NC_014650|CRISPRCasFinder,CRT,PILER-CR matches to NC_023147 (Paenibacillus larvae subsp. larvae DSM 25430 plasmid pPLA2_10, complete sequence) position: , mismatch: 6, identity: 0.838

atgacatgggaattcatgtagagatgactgggcaagg	CRISPR spacer
caaatatgggaattcatgttgagatgactggccaagg	Protospacer
  .*.************** *********** *****

8. spacer 7.22|1451618|39|NC_014650|CRISPRCasFinder,CRT,PILER-CR matches to NC_019544 (Deep-sea thermophilic phage D6E, complete genome) position: , mismatch: 6, identity: 0.846

atgctttttgcataaaaacctgcataaaagggaggtgaa	CRISPR spacer
tggaaaattgcataaaaacctgcataaaagggaggtgaa	Protospacer
  *    ********************************

9. spacer 4.16|591679|35|NC_014650|CRISPRCasFinder,CRT,PILER-CR matches to NC_018265 (Melissococcus plutonius DAT561 plasmid 1, complete sequence) position: , mismatch: 7, identity: 0.8

gaattcaatcaatgcttttttagatag----aatttcag	CRISPR spacer
gaattcaatctatgattttttagattgctgtaatt----	Protospacer
********** *** ********** *    ****

10. spacer 12.13|3432289|37|NC_014650|CRISPRCasFinder,CRT,PILER-CR matches to MF595878 (Caldibacillus phage CBP1, complete genome) position: , mismatch: 7, identity: 0.811

gttcatccagctggcgttgcatatcaaagagaaccgc	CRISPR spacer
gttcatccagctggcgttgcagatcaaagagtttttg	Protospacer
********************* *********  ..

11. spacer 4.16|591679|35|NC_014650|CRISPRCasFinder,CRT,PILER-CR matches to NC_010371 (Finegoldia magna ATCC 29328 plasmid pFMC, complete sequence) position: , mismatch: 8, identity: 0.771

--gaattcaatcaatgcttttttagatagaatttcag	CRISPR spacer
aaaagctcga--aatggttttttagatagaatatcag	Protospacer
  .*..**.*  **** *************** ****

12. spacer 7.17|1451291|34|NC_014650|CRISPRCasFinder,CRT,PILER-CR matches to MT701590 (Klebsiella phage Miami, complete genome) position: , mismatch: 8, identity: 0.765

actcaataagaataaacatcattcttacaaactc	CRISPR spacer
cgaagataaggataaatatcattcttacaaactg	Protospacer
    .*****.*****.****************

13. spacer 14.1|3757339|36|NC_014650|CRISPRCasFinder matches to MG065689 (UNVERIFIED: Campylobacter phage A110a, complete genome) position: , mismatch: 8, identity: 0.778

ctcatctgtttcgccttcttgtttaatctcatccaa	CRISPR spacer
ttcatctgtttctccttcttatttaatctgtattaa	Protospacer
.*********** *******.********   ..**

14. spacer 14.1|3757339|36|NC_014650|CRISPRCasFinder matches to MT932211 (Escherichia phage VEcB, complete genome) position: , mismatch: 8, identity: 0.778

ctcatctgtttcgccttcttgtttaatctcatccaa	CRISPR spacer
ttcatctgtttctccttcttatttaatctgtattaa	Protospacer
.*********** *******.********   ..**

15. spacer 14.1|3757339|36|NC_014650|CRISPRCasFinder matches to MN850601 (Escherichia phage inny, complete genome) position: , mismatch: 8, identity: 0.778

ctcatctgtttcgccttcttgtttaatctcatccaa	CRISPR spacer
ttcatctgtttctccttcttatttaatctgtattaa	Protospacer
.*********** *******.********   ..**

16. spacer 14.1|3757339|36|NC_014650|CRISPRCasFinder matches to KU522583 (Enterobacteria phage ECGD1, complete genome) position: , mismatch: 8, identity: 0.778

ctcatctgtttcgccttcttgtttaatctcatccaa	CRISPR spacer
ttcatctgtttctccttcttatttaatctgtattaa	Protospacer
.*********** *******.********   ..**

17. spacer 14.1|3757339|36|NC_014650|CRISPRCasFinder matches to MN850645 (Escherichia phage outra, complete genome) position: , mismatch: 8, identity: 0.778

ctcatctgtttcgccttcttgtttaatctcatccaa	CRISPR spacer
ttcatctgtttctccttcttatttaatctgtattaa	Protospacer
.*********** *******.********   ..**

18. spacer 14.1|3757339|36|NC_014650|CRISPRCasFinder matches to MN850584 (Escherichia phage arall, complete genome) position: , mismatch: 8, identity: 0.778

ctcatctgtttcgccttcttgtttaatctcatccaa	CRISPR spacer
ttcatctgtttctccttcttatttaatctgtattaa	Protospacer
.*********** *******.********   ..**

19. spacer 14.1|3757339|36|NC_014650|CRISPRCasFinder matches to MH675927 (Escherichia phage vB_vPM_PD114, complete genome) position: , mismatch: 8, identity: 0.778

ctcatctgtttcgccttcttgtttaatctcatccaa	CRISPR spacer
ttcatctgtttctccttcttatttaatctgtattaa	Protospacer
.*********** *******.********   ..**

20. spacer 14.1|3757339|36|NC_014650|CRISPRCasFinder matches to FR775895 (Enterobacteria phage phi92, complete genome) position: , mismatch: 8, identity: 0.778

ctcatctgtttcgccttcttgtttaatctcatccaa	CRISPR spacer
ttcatctgtttctccttcttatttaatctgtattaa	Protospacer
.*********** *******.********   ..**

21. spacer 14.1|3757339|36|NC_014650|CRISPRCasFinder matches to MG065645 (UNVERIFIED: Campylobacter phage A145, complete genome) position: , mismatch: 8, identity: 0.778

ctcatctgtttcgccttcttgtttaatctcatccaa	CRISPR spacer
ttcatctgtttctccttcttatttaatctgtattaa	Protospacer
.*********** *******.********   ..**

22. spacer 14.1|3757339|36|NC_014650|CRISPRCasFinder matches to MN850632 (Escherichia phage alia, complete genome) position: , mismatch: 8, identity: 0.778

ctcatctgtttcgccttcttgtttaatctcatccaa	CRISPR spacer
ttcatctgtttctccttcttatttaatctgtattaa	Protospacer
.*********** *******.********   ..**

23. spacer 14.1|3757339|36|NC_014650|CRISPRCasFinder matches to MN850573 (Escherichia phage muut, complete genome) position: , mismatch: 8, identity: 0.778

ctcatctgtttcgccttcttgtttaatctcatccaa	CRISPR spacer
ttcatctgtttctccttcttatttaatctgtattaa	Protospacer
.*********** *******.********   ..**

24. spacer 14.1|3757339|36|NC_014650|CRISPRCasFinder matches to MG065639 (UNVERIFIED: Campylobacter phage A150, complete genome) position: , mismatch: 8, identity: 0.778

ctcatctgtttcgccttcttgtttaatctcatccaa	CRISPR spacer
ttcatctgtttctccttcttatttaatctgtattaa	Protospacer
.*********** *******.********   ..**

25. spacer 14.1|3757339|36|NC_014650|CRISPRCasFinder matches to MG065656 (UNVERIFIED: Campylobacter phage C3, complete genome) position: , mismatch: 8, identity: 0.778

ctcatctgtttcgccttcttgtttaatctcatccaa	CRISPR spacer
ttcatctgtttctccttcttatttaatctgtattaa	Protospacer
.*********** *******.********   ..**

26. spacer 14.1|3757339|36|NC_014650|CRISPRCasFinder matches to MH816848 (Escherichia phage vB_vPM_PD06, complete genome) position: , mismatch: 8, identity: 0.778

ctcatctgtttcgccttcttgtttaatctcatccaa	CRISPR spacer
ttcatctgtttctccttcttatttaatctgtattaa	Protospacer
.*********** *******.********   ..**

27. spacer 7.17|1451291|34|NC_014650|CRISPRCasFinder,CRT,PILER-CR matches to HQ615693 (Synechococcus phage S-CRM01, complete genome) position: , mismatch: 9, identity: 0.735

actcaataagaataaacatcattcttacaaactc	CRISPR spacer
cctaaataagaataaacattattcttattattat	Protospacer
 ** ***************.*******. * . .

28. spacer 9.3|1954411|35|NC_014650|CRISPRCasFinder,CRT matches to NC_018878 (Bacillus thuringiensis Bt407 plasmid BTB_502p, complete sequence) position: , mismatch: 9, identity: 0.743

gaggatttgaaagtgaaaaatatgcaacaaaatca	CRISPR spacer
caactatggaaagtgaaaaacatgcaacaaaatgc	Protospacer
 *.   * ************.************

29. spacer 12.7|3431889|35|NC_014650|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP039693 (Agrobacterium larrymoorei strain CFBP5473 plasmid pAlCFBP5473, complete sequence) position: , mismatch: 9, identity: 0.743

ggcgaaaaaggtagagcttcagaagaaaaaagaat	CRISPR spacer
cggaaagttggtcgagctccagaagaaaaaagaag	Protospacer
 * .**.  *** *****.***************

30. spacer 12.7|3431889|35|NC_014650|CRISPRCasFinder,CRT,PILER-CR matches to MN694222 (Marine virus AFVG_250M1115, complete genome) position: , mismatch: 10, identity: 0.714

ggcgaaaaaggtagagcttcagaagaaaaaagaat	CRISPR spacer
gcaattggagctagagcttcagaaggaaaaagaaa	Protospacer
*  .  ..** **************.********

31. spacer 12.7|3431889|35|NC_014650|CRISPRCasFinder,CRT,PILER-CR matches to MN694536 (Marine virus AFVG_250M991, complete genome) position: , mismatch: 10, identity: 0.714

ggcgaaaaaggtagagcttcagaagaaaaaagaat	CRISPR spacer
gcaattggagctagagcttcagaaggaaaaagaaa	Protospacer
*  .  ..** **************.********

32. spacer 12.7|3431889|35|NC_014650|CRISPRCasFinder,CRT,PILER-CR matches to MN693925 (Marine virus AFVG_250M1114, complete genome) position: , mismatch: 10, identity: 0.714

ggcgaaaaaggtagagcttcagaagaaaaaagaat	CRISPR spacer
gcaattggagctagagcttcagaaggaaaaagaaa	Protospacer
*  .  ..** **************.********

33. spacer 3.4|263906|35|NC_014650|PILER-CR,CRISPRCasFinder,CRT matches to MK496794 (Capybara microvirus Cap3_SP_445, complete genome) position: , mismatch: 11, identity: 0.686

ttctcctcttgttggtcaatatattgtttgtaatt	CRISPR spacer
aaaacctctggttggtcaatacattgtttgattcc	Protospacer
    ***** ***********.********   ..

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

487253 : 525396

Acinetobacter_phage(12.5%)

bacteriocin,coat,transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003248148.1\|487253_487466_+\|bacteriocin	bacteriocin immunity protein	NA	NA	NA	NA
WP_013400033.1\|488621_489104_+	antitoxin YezG family protein	NA	NA	NA	NA
WP_049780701.1\|489988_490876_+	pre-toxin TG domain-containing protein	NA	NA	NA	NA
WP_013400035.1\|490865_491255_+	hypothetical protein	NA	NA	NA	NA
WP_006324125.1\|492299_492650_+\|transposase	transposase	NA	NA	NA	NA
WP_041269295.1\|494415_494649_+	MafI family immunity protein	NA	NA	NA	NA
WP_083787367.1\|494819_495272_+\|transposase	IS3 family transposase	A0A0P0I4A4	Acinetobacter_phage	2.8e-24	45.8
WP_013400037.1\|495555_496791_-\|transposase	IS256 family transposase	A0A0K2CZ57	Paenibacillus_phage	1.5e-141	64.5
WP_013400038.1\|497057_497300_+	YuzF family protein	NA	NA	NA	NA
WP_003248174.1\|497361_498258_+	manganese catalase family protein	NA	NA	NA	NA
WP_003248176.1\|498464_499931_-	catalase	A0A2K9L0T1	Tupanvirus	4.7e-113	41.6
WP_003248178.1\|500062_500962_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_003248180.1\|501167_502643_+	4-hydroxyphenylacetate 3-monooxygenase, oxygenase component	NA	NA	NA	NA
WP_013400039.1\|502668_503652_+	3,4-dihydroxyphenylacetate 2,3-dioxygenase	NA	NA	NA	NA
WP_041269436.1\|503994_504471_+	flavin reductase family protein	NA	NA	NA	NA
WP_013400041.1\|504761_505679_+	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase	NA	NA	NA	NA
WP_013400042.1\|505703_506519_+	fumarylacetoacetate hydrolase family protein	NA	NA	NA	NA
WP_013400043.1\|506493_507231_+	fumarylacetoacetate hydrolase family protein	NA	NA	NA	NA
WP_013400044.1\|507247_507634_+	5-carboxymethyl-2-hydroxymuconate Delta-isomerase	NA	NA	NA	NA
WP_003248193.1\|507656_509171_+	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase	NA	NA	NA	NA
WP_013400045.1\|509224_509869_+	GntR family transcriptional regulator	NA	NA	NA	NA
WP_013400046.1\|510093_511263_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_013400047.1\|511341_512223_+	branched-chain amino acid ABC transporter permease	NA	NA	NA	NA
WP_013400048.1\|512235_513300_+	branched-chain amino acid ABC transporter permease	NA	NA	NA	NA
WP_013400049.1\|513296_514073_+	ABC transporter ATP-binding protein	A0A2R8FG22	Brazilian_cedratvirus	5.5e-12	27.1
WP_003248205.1\|514073_514820_+	ABC transporter ATP-binding protein	A0A1M7XV31	Cedratvirus	5.4e-09	26.7
WP_013400050.1\|514937_515504_-	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_013400051.1\|515959_516907_+	ABC transporter permease	A0A2H4IY97	uncultured_Caudovirales_phage	1.1e-88	53.1
WP_013400052.1\|516899_517850_+	iron chelate uptake ABC transporter family permease subunit	NA	NA	NA	NA
WP_013400053.1\|517843_518602_+	ABC transporter ATP-binding protein	Q9EMR9	Amsacta_moorei_entomopoxvirus	3.1e-20	28.9
WP_013400054.1\|518724_519681_+	siderophore ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_013400055.1\|519922_520486_+	biotin transporter BioY	NA	NA	NA	NA
WP_013400056.1\|520485_521205_+	dethiobiotin synthase	NA	NA	NA	NA
WP_013400057.1\|521194_522562_+	adenosylmethionine--8-amino-7-oxononanoate transaminase	NA	NA	NA	NA
WP_003248222.1\|522695_522908_+	hypothetical protein	NA	NA	NA	NA
WP_013399800.1\|523358_524909_-\|transposase	IS1182 family transposase	Q9MBP7	Staphylococcus_prophage	6.1e-71	33.5
WP_003248226.1\|525063_525396_-\|coat	spore coat protein	NA	NA	NA	NA

DBSCAN-SWA_2

606528 : 688783

103

Bacillus_phage(23.26%)

transposase,portal,tail,terminase,head,protease,holin,tRNA,integrase,plate,capsid

attL 667477:667493|attR 692386:692402

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013400099.1\|606528_607299_+\|tRNA	alanyl-tRNA editing protein	NA	NA	NA	NA
WP_013400037.1\|607433_608669_-\|transposase	IS256 family transposase	A0A0K2CZ57	Paenibacillus_phage	1.5e-141	64.5
WP_013400100.1\|609095_609545_-	NUDIX domain-containing protein	NA	NA	NA	NA
WP_158306615.1\|609815_609911_+	hypothetical protein	NA	NA	NA	NA
WP_013400101.1\|610195_611395_-\|integrase	site-specific integrase	S5MNZ2	Brevibacillus_phage	4.7e-103	50.9
WP_013400102.1\|611425_611575_-	Arm DNA-binding domain-containing protein	A0A2H4JCB7	uncultured_Caudovirales_phage	4.8e-10	76.2
WP_013400103.1\|611662_612178_-	ImmA/IrrE family metallo-endopeptidase	NA	NA	NA	NA
WP_041269439.1\|612279_613149_-	DNA adenine methylase	NA	NA	NA	NA
WP_013400105.1\|613206_614892_-	AAA family ATPase	NA	NA	NA	NA
WP_185948723.1\|615539_615704_-	hypothetical protein	NA	NA	NA	NA
WP_013400106.1\|615741_617334_-	hypothetical protein	NA	NA	NA	NA
WP_013400107.1\|617994_618441_-	helix-turn-helix transcriptional regulator	A0A1L2JY18	Aeribacillus_phage	2.5e-25	78.3
WP_013400108.1\|618627_618861_+	helix-turn-helix transcriptional regulator	A0A1L2JY14	Aeribacillus_phage	4.7e-20	67.6
WP_013400109.1\|618909_619215_+	hypothetical protein	NA	NA	NA	NA
WP_013400110.1\|619221_619590_-	hypothetical protein	NA	NA	NA	NA
WP_013400111.1\|619660_619846_+	helix-turn-helix domain-containing protein	U5P0W4	Brevibacillus_phage	3.0e-09	56.4
WP_013400112.1\|619909_620431_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_013400113.1\|620446_620605_+	hypothetical protein	A0A1B1P7M3	Bacillus_phage	1.7e-05	59.5
WP_013400114.1\|620796_621054_+	hypothetical protein	NA	NA	NA	NA
WP_152332996.1\|621071_621431_+	zinc-finger domain-containing protein	S6BFM8	Thermus_phage	1.2e-09	33.3
WP_013400116.1\|621481_621652_+	hypothetical protein	NA	NA	NA	NA
WP_013400117.1\|621710_622664_+	DnaD domain protein	A0A0U4JX08	Bacillus_phage	7.9e-37	67.6
WP_152333020.1\|622901_623090_+	Fur-regulated basic protein FbpA	NA	NA	NA	NA
WP_003252929.1\|623380_623590_+	hypothetical protein	NA	NA	NA	NA
WP_013400122.1\|623591_623807_+	hypothetical protein	NA	NA	NA	NA
WP_041269302.1\|623812_624040_+	hypothetical protein	NA	NA	NA	NA
WP_013400123.1\|624081_624579_+	hypothetical protein	NA	NA	NA	NA
WP_013400124.1\|624790_624949_+	hypothetical protein	NA	NA	NA	NA
WP_013400125.1\|625045_625255_+	hypothetical protein	NA	NA	NA	NA
WP_035502451.1\|625296_625734_+	ASCH domain-containing protein	L7TM42	Rhizobium_phage	7.6e-11	35.1
WP_003252923.1\|625892_626627_+	hypothetical protein	NA	NA	NA	NA
WP_003252921.1\|626668_627835_+	XRE family transcriptional regulator	A0A0A7RTT7	Clostridium_phage	1.2e-76	40.7
WP_013400127.1\|627952_628144_+	hypothetical protein	NA	NA	NA	NA
WP_013400128.1\|628168_628633_+	ArpU family transcriptional regulator	S6AVV9	Thermus_phage	7.2e-44	63.2
WP_013400129.1\|628629_629172_+\|integrase	site-specific integrase	D2XR58	Bacillus_phage	1.3e-73	73.9
WP_013400130.1\|629411_629693_+	hypothetical protein	NA	NA	NA	NA
WP_152332997.1\|629953_630139_+	hypothetical protein	NA	NA	NA	NA
WP_013400131.1\|630368_630644_+	hypothetical protein	NA	NA	NA	NA
WP_013400132.1\|630853_631528_+	hypothetical protein	NA	NA	NA	NA
WP_013400133.1\|631576_631984_+	HNH endonuclease	A0A1U7Q1S7	Geobacillus_virus	1.4e-35	56.9
WP_013400134.1\|632095_632590_+\|terminase	phage terminase small subunit P27 family	A6M947	Geobacillus_virus	1.3e-54	63.8
WP_013400135.1\|632586_634314_+\|terminase	terminase large subunit	A0A0S2GLF0	Bacillus_phage	8.0e-197	58.4
WP_041269305.1\|634318_634504_+	hypothetical protein	NA	NA	NA	NA
WP_013400136.1\|634520_635810_+\|portal	phage portal protein	Q2I8F9	Bacillus_phage	2.7e-165	66.4
WP_041269306.1\|635751_636372_+\|head,protease	HK97 family phage prohead protease	Q2I8F8	Bacillus_phage	2.5e-84	76.2
WP_013400138.1\|636417_637620_+\|capsid	phage major capsid protein	A0A288WG01	Bacillus_phage	1.4e-112	55.5
WP_041269307.1\|637638_637935_+	hypothetical protein	A6XMJ7	Bacillus_virus	8.4e-06	39.5
WP_013400140.1\|637966_638260_+\|head,tail	phage gp6-like head-tail connector protein	A6M953	Geobacillus_virus	2.5e-26	59.6
WP_013400141.1\|638256_638865_+\|head,tail	head-tail adaptor protein	NA	NA	NA	NA
WP_013400142.1\|638864_639260_+	HK97 gp10 family phage protein	NA	NA	NA	NA
WP_013400143.1\|639256_639676_+	hypothetical protein	S5MUN8	Brevibacillus_phage	5.0e-12	33.9
WP_013400144.1\|639675_640752_+\|tail	phage tail sheath subtilisin-like domain-containing protein	A0A0A7S0D2	Clostridium_phage	1.0e-80	45.8
WP_013400145.1\|640766_641201_+\|tail	phage tail tube protein	A0A1V0DZX1	Clostridioides_phage	2.1e-29	46.1
WP_013400146.1\|641244_641658_+	XkdN-like protein	A0A090EUD0	Clostridium_phage	4.8e-15	38.2
WP_013400147.1\|641672_641846_+	hypothetical protein	NA	NA	NA	NA
WP_013400148.1\|641856_643527_+	hypothetical protein	A0A0A8WFP0	Clostridium_phage	4.1e-41	37.6
WP_013400149.1\|643523_644174_+	LysM peptidoglycan-binding domain-containing protein	A0A2H4J2N2	uncultured_Caudovirales_phage	1.7e-38	38.2
WP_013400150.1\|644170_645145_+	hypothetical protein	A0A2H4IZP4	uncultured_Caudovirales_phage	2.6e-59	39.7
WP_013400151.1\|645144_645471_+	DUF2577 domain-containing protein	NA	NA	NA	NA
WP_013400152.1\|645467_645884_+	DUF2634 domain-containing protein	A0A2H4J6K5	uncultured_Caudovirales_phage	1.2e-21	44.1
WP_013400153.1\|645876_646935_+\|plate	baseplate J/gp47 family protein	S6AVU3	Thermus_phage	2.0e-65	43.2
WP_013400154.1\|646931_647498_+	YmfQ family protein	S6BFJ0	Thermus_phage	5.3e-33	43.9
WP_083787422.1\|647578_647860_+\|tail	tail fiber protein	NA	NA	NA	NA
WP_013400156.1\|647860_648166_+	hypothetical protein	A0A0K1Y8A9	Streptomyces_phage	3.1e-11	50.5
WP_013400158.1\|648622_649003_+	hypothetical protein	S6C455	Thermus_phage	2.2e-46	75.8
WP_013400159.1\|649004_649145_+	hypothetical protein	S6B9W8	Thermus_phage	1.7e-12	81.8
WP_041269442.1\|649236_649656_+\|holin	phage holin family protein	Q0H258	Geobacillus_phage	2.6e-40	62.8
WP_013400161.1\|649652_650303_+	glucosaminidase domain-containing protein	Q9ZXE4	Bacillus_phage	4.1e-37	53.3
WP_013400162.1\|650592_651270_-	MgtC/SapB family protein	G3MA03	Bacillus_virus	3.9e-14	35.5
WP_013400163.1\|651336_652245_+	DMT family transporter	NA	NA	NA	NA
WP_013400164.1\|652221_653043_-	protein-glutamine gamma-glutamyltransferase	NA	NA	NA	NA
WP_013399926.1\|661738_663268_-\|transposase	IS21 family transposase	NA	NA	NA	NA
WP_013400166.1\|663564_663741_+	hypothetical protein	NA	NA	NA	NA
WP_013400167.1\|663741_663960_+	hypothetical protein	NA	NA	NA	NA
WP_013400168.1\|664326_664854_+	hypothetical protein	NA	NA	NA	NA
WP_013399860.1\|665091_666261_-\|transposase	IS256 family transposase	A0A0K2CZ57	Paenibacillus_phage	1.2e-23	25.1
WP_185948724.1\|666406_666565_+	hypothetical protein	NA	NA	NA	NA
WP_013400169.1\|666609_667302_+	hypothetical protein	NA	NA	NA	NA
667477:667493	attL	NA	NA	NA	NA
WP_152332998.1\|667879_668167_+	hypothetical protein	NA	NA	NA	NA
WP_013400170.1\|668563_669091_-\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_013400171.1\|669081_669636_-\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_152333021.1\|669857_670025_+	SHOCT domain-containing protein	NA	NA	NA	NA
WP_013400173.1\|670350_671175_+	recombinase family protein	A0A097BYD1	Leuconostoc_phage	7.8e-33	36.8
WP_013400174.1\|671584_672118_+	hypothetical protein	NA	NA	NA	NA
WP_152332999.1\|673343_674141_+\|transposase	transposase	A0A142F1N9	Bacillus_phage	2.6e-25	41.6
WP_013400177.1\|674528_675758_+	MFS transporter	NA	NA	NA	NA
WP_013400178.1\|675826_676531_+	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_013400179.1\|676734_677100_+	cupin domain-containing protein	NA	NA	NA	NA
WP_041269308.1\|677247_677883_+	O-methyltransferase	NA	NA	NA	NA
WP_013400181.1\|678063_678831_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_013400182.1\|679125_679500_+	VOC family protein	NA	NA	NA	NA
WP_013400183.1\|679673_680108_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_013400184.1\|680063_680690_-\|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	2.8e-27	40.6
WP_013400185.1\|680698_680995_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_013400186.1\|681742_682069_-	hypothetical protein	NA	NA	NA	NA
WP_013399927.1\|682404_683145_-	ATP-binding protein	A0A2L1IVB6	Escherichia_phage	3.2e-38	41.5
WP_013399926.1\|683116_684646_-\|transposase	IS21 family transposase	NA	NA	NA	NA
WP_152333022.1\|684830_685031_+\|transposase	transposase	NA	NA	NA	NA
WP_152333000.1\|685199_685670_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	U5P429	Shigella_phage	8.7e-21	53.8
WP_185215591.1\|685808_686411_+	nucleotidyltransferase family protein	NA	NA	NA	NA
WP_013400189.1\|686440_686722_+	hypothetical protein	NA	NA	NA	NA
WP_013400190.1\|687151_687562_+	Rrf2 family transcriptional regulator	NA	NA	NA	NA
WP_003248425.1\|687670_688783_+\|tRNA	tRNA 2-thiouridine(34) synthase MnmA	NA	NA	NA	NA
692386:692402	attR	NA	NA	NA	NA

DBSCAN-SWA_3

735113 : 743524

Staphylococcus_phage(57.14%)

holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013400209.1\|735113_735344_-	membrane protein insertion efficiency factor YidD	A0A2H4PQM5	Staphylococcus_phage	4.5e-23	65.8
WP_003248497.1\|735510_735984_+	S-ribosylhomocysteine lyase	NA	NA	NA	NA
WP_003248499.1\|736236_736677_+	DNA starvation/stationary phase protection protein	A0A0A7RTZ1	Clostridium_phage	2.2e-58	76.0
WP_013400210.1\|736801_737197_+\|holin	phage holin family protein	A0A0N7GFE6	Paenibacillus_phage	1.7e-25	47.5
WP_003248503.1\|737270_737594_+	hypothetical protein	NA	NA	NA	NA
WP_013400211.1\|737688_738150_+	nucleoside triphosphatase YtkD	A0A2H4PQM4	Staphylococcus_phage	1.4e-18	36.0
WP_013400212.1\|738164_738974_-	ABC transporter permease	NA	NA	NA	NA
WP_003248508.1\|738957_739731_-	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	1.3e-34	37.9
WP_003248509.1\|739749_740748_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_003248515.1\|740848_741637_+	S9 family peptidase	A0A2H4PQM6	Staphylococcus_phage	7.9e-35	39.4
WP_003248518.1\|741666_741909_+	DUF2584 domain-containing protein	NA	NA	NA	NA
WP_003248519.1\|741937_743524_-	phosphoenolpyruvate carboxykinase (ATP)	A0A2H4PQN1	Staphylococcus_phage	9.9e-194	63.8

DBSCAN-SWA_4

1245310 : 1255112

Staphylococcus_phage(44.44%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003249415.1\|1245310_1246396_+	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	7.0e-58	37.5
WP_013400462.1\|1246411_1247059_+	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	1.0e-43	48.5
WP_003249418.1\|1247079_1248273_+	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	5.6e-117	54.1
WP_003249421.1\|1248345_1248813_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	4.2e-44	63.5
WP_003249422.1\|1248932_1249280_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_013400463.1\|1249292_1249808_-	DUF309 domain-containing protein	NA	NA	NA	NA
WP_013400464.1\|1249924_1250695_+	segregation/condensation protein A	A0A1B1IVW1	uncultured_Mediterranean_phage	5.1e-10	42.1
WP_003249425.1\|1250681_1251272_+	SMC-Scp complex subunit ScpB	A0A1B1IVT7	uncultured_Mediterranean_phage	3.9e-18	39.2
WP_003249426.1\|1251335_1251755_+	hypothetical protein	NA	NA	NA	NA
WP_185948728.1\|1251778_1252270_+	DUF3907 family protein	NA	NA	NA	NA
WP_083787379.1\|1252313_1252709_-	DUF2935 domain-containing protein	A0A2I2L551	Orpheovirus	1.2e-15	39.1
WP_013400466.1\|1252867_1253779_+	superoxide dismutase	Q56AR7	Bacillus_thuringiensis_phage	4.7e-39	43.1
WP_003249429.1\|1253972_1255112_+	D-alanyl-D-alanine carboxypeptidase	B6DZZ7	Stx2-converting_phage	3.8e-22	34.6

DBSCAN-SWA_5

1317571 : 1328378

Pandoravirus(25.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003249561.1\|1317571_1317844_+	HU family DNA-binding protein	A0A0H3UZA0	Geobacillus_virus	1.3e-29	72.2
WP_013400508.1\|1317985_1318552_+	GTP cyclohydrolase I FolE	E7DN69	Pneumococcus_phage	2.2e-50	55.4
WP_003249564.1\|1318586_1318811_+	trp RNA-binding attenuation protein MtrB	NA	NA	NA	NA
WP_003249566.1\|1318901_1319717_+	heptaprenyl diphosphate synthase component 1	NA	NA	NA	NA
WP_013400509.1\|1319721_1320426_+	demethylmenaquinone methyltransferase	NA	NA	NA	NA
WP_013400510.1\|1320440_1321406_+	heptaprenyl diphosphate synthase component II	A0A1V0SE37	Indivirus	7.8e-08	24.4
WP_003249570.1\|1321505_1321952_+	nucleoside-diphosphate kinase	D2E8E1	Anguillid_herpesvirus	1.4e-28	45.8
WP_013400511.1\|1322080_1322854_+	protein-glutamate O-methyltransferase CheR	NA	NA	NA	NA
WP_013400512.1\|1322972_1324139_+	chorismate synthase	A0A291AU41	Pandoravirus	1.8e-43	36.7
WP_013400513.1\|1324138_1325242_+	3-dehydroquinate synthase	E5ERI4	Ostreococcus_lucimarinus_virus	4.1e-21	24.6
WP_003249581.1\|1325250_1325655_+	chorismate mutase	NA	NA	NA	NA
WP_013400515.1\|1325839_1327366_+	anthranilate synthase component I	A0A0B5J984	Pandoravirus	6.1e-31	30.0
WP_003249589.1\|1327358_1328378_+	anthranilate phosphoribosyltransferase	A0A0N7IRD9	Acinetobacter_phage	8.6e-66	41.7

DBSCAN-SWA_6

2281020 : 2338189

Paenibacillus_phage(33.33%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013400421.1\|2281020_2281911_-\|transposase	transposase	NA	NA	NA	NA
WP_013400037.1\|2282139_2283375_+\|transposase	IS256 family transposase	A0A0K2CZ57	Paenibacillus_phage	1.5e-141	64.5
WP_013401061.1\|2283839_2284670_-	nicotianamine synthase	NA	NA	NA	NA
WP_013401062.1\|2284680_2285985_-	MATE family efflux transporter	NA	NA	NA	NA
WP_013401063.1\|2286000_2286768_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	4.6e-19	29.6
WP_013401064.1\|2286784_2287594_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	3.4e-17	32.0
WP_013401065.1\|2287606_2288428_-	ABC transporter permease subunit	NA	NA	NA	NA
WP_013401066.1\|2288424_2289366_-	ABC transporter permease	NA	NA	NA	NA
WP_013401067.1\|2289367_2290888_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_003251190.1\|2291239_2292025_+	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	2.6e-38	38.9
WP_003251192.1\|2292118_2293087_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_013401068.1\|2293091_2293859_+	ABC transporter permease	NA	NA	NA	NA
WP_003251196.1\|2293914_2294364_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_003251198.1\|2294697_2295231_+	DUF4242 domain-containing protein	NA	NA	NA	NA
WP_013401069.1\|2295501_2296566_+	acyl-CoA/acyl-ACP dehydrogenase	NA	NA	NA	NA
WP_003251201.1\|2296941_2298645_-	methyl-accepting chemotaxis protein	A0A2H4J162	uncultured_Caudovirales_phage	8.0e-08	31.4
WP_013401070.1\|2298648_2299821_-	ATP-grasp domain-containing protein	NA	NA	NA	NA
WP_013399860.1\|2300361_2301531_+\|transposase	IS256 family transposase	A0A0K2CZ57	Paenibacillus_phage	1.2e-23	25.1
WP_003251206.1\|2301937_2302453_+	DUF1572 family protein	NA	NA	NA	NA
WP_013401071.1\|2303159_2304515_+	amino acid permease	NA	NA	NA	NA
WP_152333011.1\|2304820_2304922_-	hypothetical protein	NA	NA	NA	NA
WP_013401072.1\|2305534_2306686_+	DUF2515 domain-containing protein	NA	NA	NA	NA
WP_083787390.1\|2306612_2307068_+	hypothetical protein	NA	NA	NA	NA
WP_003251212.1\|2307153_2307897_-	SIS domain-containing protein	NA	NA	NA	NA
WP_013401074.1\|2308301_2310224_-	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_013401075.1\|2310737_2311862_+	FAD-binding oxidoreductase	NA	NA	NA	NA
WP_152333012.1\|2312647_2313241_+	TetR family transcriptional regulator	NA	NA	NA	NA
WP_013401077.1\|2313233_2313815_+	HXXEE domain-containing protein	NA	NA	NA	NA
WP_003251226.1\|2314171_2315344_-	TIGR04053 family radical SAM/SPASM domain-containing protein	NA	NA	NA	NA
WP_003251229.1\|2315953_2316421_+	DUF1097 domain-containing protein	NA	NA	NA	NA
WP_013401079.1\|2316505_2317714_+	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_013401080.1\|2317723_2318992_+	NAD-dependent dihydropyrimidine dehydrogenase subunit PreA	NA	NA	NA	NA
WP_013401081.1\|2319300_2321046_-	Cache 3/Cache 2 fusion domain-containing protein	NA	NA	NA	NA
WP_013401082.1\|2321266_2322598_+	amino acid permease	NA	NA	NA	NA
WP_013401083.1\|2323367_2323673_-	barstar family protein	NA	NA	NA	NA
WP_003251243.1\|2323686_2324133_-	ribonuclease	NA	NA	NA	NA
WP_013399926.1\|2324670_2326200_+\|transposase	IS21 family transposase	NA	NA	NA	NA
WP_013399927.1\|2326171_2326912_+	ATP-binding protein	A0A2L1IVB6	Escherichia_phage	3.2e-38	41.5
WP_003251247.1\|2327629_2327830_+	helix-turn-helix transcriptional regulator	A0A2K9V490	Faecalibacterium_phage	4.3e-06	43.5
WP_003251249.1\|2328186_2328435_-	MafI family immunity protein	NA	NA	NA	NA
WP_013401084.1\|2328458_2329556_-	EndoU domain-containing protein	NA	NA	NA	NA
WP_013401085.1\|2329552_2329867_-	hypothetical protein	NA	NA	NA	NA
WP_041269380.1\|2330501_2331365_+	SDR family oxidoreductase	NA	NA	NA	NA
WP_041269381.1\|2332804_2333023_-	hypothetical protein	NA	NA	NA	NA
WP_013400931.1\|2333088_2334324_+\|transposase	IS256 family transposase	A0A0K2CZ57	Paenibacillus_phage	8.9e-142	63.0
WP_013401088.1\|2334512_2334815_-	hypothetical protein	NA	NA	NA	NA
WP_013401090.1\|2336146_2336380_-	immunity protein 32	NA	NA	NA	NA
WP_013399926.1\|2336659_2338189_+\|transposase	IS21 family transposase	NA	NA	NA	NA

DBSCAN-SWA_7

2545003 : 2600513

Staphylococcus_prophage(16.67%)

transposase,coat,integrase,tRNA

attL 2585396:2585455|attR 2603109:2604916

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003251543.1\|2545003_2545951_-\|tRNA	tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA	NA	NA	NA	NA
WP_003251544.1\|2546086_2547778_-	methyl-accepting chemotaxis protein	A0A2H4J162	uncultured_Caudovirales_phage	2.1e-08	46.7
WP_013401219.1\|2547869_2549222_-	MFS transporter	NA	NA	NA	NA
WP_003251546.1\|2549456_2550968_+	BCCT family transporter	A0A2I7QNT1	Vibrio_phage	5.3e-27	26.7
WP_003251547.1\|2551494_2552556_+	LLM class flavin-dependent oxidoreductase	NA	NA	NA	NA
WP_003251548.1\|2552552_2553500_+	alpha-L-glutamate ligase	NA	NA	NA	NA
WP_013399800.1\|2553637_2555188_+\|transposase	IS1182 family transposase	Q9MBP7	Staphylococcus_prophage	6.1e-71	33.5
WP_155116391.1\|2555361_2555511_-	hypothetical protein	NA	NA	NA	NA
WP_003251549.1\|2555775_2556573_-	ABC transporter permease	G3M9Y4	Bacillus_virus	1.1e-23	25.5
WP_003251550.1\|2556587_2557580_-	aliphatic sulfonate ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_013401220.1\|2557635_2558394_-	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	6.7e-31	37.1
WP_003251552.1\|2558570_2559776_-	acyl-CoA/acyl-ACP dehydrogenase	NA	NA	NA	NA
WP_013401221.1\|2559804_2560878_-	dimethyl sulfone monooxygenase SfnG	NA	NA	NA	NA
WP_041269388.1\|2561046_2561607_-	NADPH-dependent FMN reductase	NA	NA	NA	NA
WP_013401223.1\|2561820_2563353_-	MFS transporter	NA	NA	NA	NA
WP_013401224.1\|2563367_2564102_-	polymer-forming cytoskeletal protein	NA	NA	NA	NA
WP_013401225.1\|2564115_2564820_-	polymer-forming cytoskeletal protein	NA	NA	NA	NA
WP_003251558.1\|2564824_2565454_-	YhbD family protein	NA	NA	NA	NA
WP_013401226.1\|2565524_2565680_+	hypothetical protein	NA	NA	NA	NA
WP_185948711.1\|2565682_2565859_+	hypothetical protein	NA	NA	NA	NA
WP_013401227.1\|2566052_2566220_+	YjcZ family sporulation protein	NA	NA	NA	NA
WP_003251559.1\|2566600_2567029_+	hypothetical protein	NA	NA	NA	NA
WP_013401229.1\|2568479_2568800_-	hypothetical protein	NA	NA	NA	NA
WP_003251564.1\|2569174_2571034_-	DNA mismatch repair endonuclease MutL	A0A1B2LRQ5	Wolbachia_phage	6.4e-67	31.7
WP_013401230.1\|2571047_2573642_-	DNA mismatch repair protein MutS	A0A2P0VN50	Tetraselmis_virus	9.6e-37	22.5
WP_003251570.1\|2574011_2574521_-	acetone carboxylase subunit gamma	NA	NA	NA	NA
WP_013401231.1\|2574533_2576804_-	hydantoinase B/oxoprolinase family protein	NA	NA	NA	NA
WP_013401232.1\|2576822_2578970_-	hydantoinase/oxoprolinase family protein	NA	NA	NA	NA
WP_003251575.1\|2579929_2580475_-\|coat	outer spore coat protein CotE	NA	NA	NA	NA
WP_003251577.1\|2580666_2581098_-	RicAFT regulatory complex protein RicA family protein	NA	NA	NA	NA
WP_003251578.1\|2581099_2582671_-\|tRNA	tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB	NA	NA	NA	NA
WP_003251580.1\|2583395_2584535_+	hypothetical protein	NA	NA	NA	NA
WP_003251581.1\|2584564_2585368_-	site-specific DNA-methyltransferase	M1Q227	Streptococcus_phage	5.1e-29	31.3
2585396:2585455	attL	NA	NA	NA	NA
WP_013399800.1\|2585526_2587077_+\|transposase	IS1182 family transposase	Q9MBP7	Staphylococcus_prophage	6.1e-71	33.5
WP_013401233.1\|2587214_2588144_-	DNA adenine methylase	A0A1L2BX38	Bacteriophage	1.4e-51	38.4
WP_013401234.1\|2588324_2588519_+	hypothetical protein	NA	NA	NA	NA
WP_013401235.1\|2588532_2589273_+	hypothetical protein	NA	NA	NA	NA
WP_003251588.1\|2589548_2590415_-	2-oxoacid:ferredoxin oxidoreductase subunit beta	NA	NA	NA	NA
WP_003251590.1\|2590418_2592155_-	2-oxoacid:acceptor oxidoreductase subunit alpha	NA	NA	NA	NA
WP_013401236.1\|2592349_2593273_-	dipeptidase	NA	NA	NA	NA
WP_003251598.1\|2593360_2593621_-	stage V sporulation protein SpoVS	J9PTX7	Bacillus_phage	1.9e-09	43.8
WP_013401237.1\|2593747_2594542_-	TIGR00282 family metallophosphoesterase	NA	NA	NA	NA
WP_003251600.1\|2594625_2596191_-	ribonuclease Y	NA	NA	NA	NA
WP_013401238.1\|2596892_2598032_+\|integrase	tyrosine-type recombinase/integrase	A0A0A8WIE1	Clostridium_phage	5.6e-13	26.9
WP_013401239.1\|2598028_2600140_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_013401240.1\|2600132_2600513_+\|transposase	transposase	NA	NA	NA	NA
2603109:2604916	attR	NA	NA	NA	NA

DBSCAN-SWA_8

2943535 : 2958042

Paenibacillus_phage(75.0%)

transposase,integrase

attL 2935266:2935279|attR 2948172:2948185

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2935266:2935279	attL	NA	NA	NA	NA
WP_080561277.1\|2943535_2943673_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_013401399.1\|2943974_2945210_+\|transposase	IS256 family transposase	A0A0K2CZ57	Paenibacillus_phage	1.3e-140	62.7
WP_152333016.1\|2945883_2946066_-	hypothetical protein	NA	NA	NA	NA
WP_013401400.1\|2946210_2946768_+	signal peptidase I	NA	NA	NA	NA
WP_013401401.1\|2947204_2948722_+\|transposase	IS21 family transposase	NA	NA	NA	NA
2948172:2948185	attR	NA	NA	NA	NA
WP_013399917.1\|2948709_2949429_+	ATP-binding protein	A0A059NT77	Lactococcus_phage	3.0e-33	41.1
WP_013400797.1\|2949708_2950878_-\|transposase	IS256 family transposase	A0A0K2CZ57	Paenibacillus_phage	2.5e-24	25.2
WP_013401402.1\|2952192_2953161_+	hypothetical protein	NA	NA	NA	NA
WP_013400797.1\|2955257_2956427_-\|transposase	IS256 family transposase	A0A0K2CZ57	Paenibacillus_phage	2.5e-24	25.2
WP_013401403.1\|2956698_2956956_-	hypothetical protein	NA	NA	NA	NA
WP_013401404.1\|2957127_2958042_+\|transposase	ISNCY family transposase	NA	NA	NA	NA

DBSCAN-SWA_9

3520562 : 3530362

Synechococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013401748.1\|3520562_3522101_-	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	Q58MG4	Prochlorococcus_phage	6.7e-78	53.3
WP_013401749.1\|3522116_3522686_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	1.9e-30	40.2
WP_013401750.1\|3522682_3523723_-	phosphoribosylformylglycinamidine cyclo-ligase	A0A0E3F760	Synechococcus_phage	3.5e-70	44.1
WP_013401751.1\|3523737_3525150_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	8.6e-48	32.6
WP_013401752.1\|3525125_3527354_-	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	5.3e-169	42.5
WP_003253326.1\|3527337_3528024_-	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_013401753.1\|3528020_3528275_-	phosphoribosylformylglycinamidine synthase subunit PurS	A0A0E3FG65	Synechococcus_phage	3.2e-06	38.3
WP_013401754.1\|3528267_3528990_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	M4R1E8	Synechococcus_phage	7.0e-46	43.0
WP_003253332.1\|3529066_3530362_-	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	3.5e-19	35.2

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_014650

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection