CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_014666	Frankia inefficax, complete sequence	21 crisprs	cas3,cas4,csa3,casR,DEDDh,WYL,cas6,RT	2	10	1	0

1. NC_014666

CRISPR-Cas detection and classification

Crispr_ID: NC_014666_1

• CRISPR_ID: NC_014666_1
• CRISPR_location: 897463-897535
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_014666_1

Consensus_repeat	Method
GACCACGGTCAGGGTGGTTATGGCCAGC	CRISPRCasFinder

spacers of NC_014666_1

>1.1|897491|17|NC_014666|CRISPRCasFinder
CGGACCATGGTCAGCTC

CRISPR arrays and Neighbor proteins around NC_014666_1

CRISPR arrays

The CRISPR arrays of NC_014666_1

>merge|NC_014666|1|897463-897535|CRISPRCasFinder
GACCACGGTCAGGGTGGTTATGGCCAGCCGGACCATGGTCAGCTCGACCGTAGTCAGGCCGGTTACAGCCAGC

>NC_014666|1|1|897463-897535|CRISPRCasFinder
GACCACGGTCAGGGTGGTTATGGCCAGC	CGGACCATGGTCAGCTC
GACCGTAGTCAGGCCGGTTACAGCCAGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_014666.1|WP_013421914.1|899240_900311_+|succinyl-diaminopimelate-desuccinylase	unknown	unknown	gnl|CDD|237264
NC_014666.1|WP_049807099.1|902075_902888_-|dihydropteroate-synthase	unknown	unknown	gnl|CDD|273657
NC_014666.1|WP_157735289.1|893882_894326_+|hypothetical-protein	unknown	unknown	unknown
NC_014666.1|WP_007511639.1|903899_904067_+|DUF3117-domain-containing-protein	unknown	unknown	gnl|CDD|371461
NC_014666.1|WP_013421922.1|907738_908401_-|O-methyltransferase	unknown	unknown	gnl|CDD|226607
NC_014666.1|WP_013421916.1|901464_902067_+|TIGR00730-family-Rossman-fold-protein	unknown	unknown	gnl|CDD|129813
NC_014666.1|WP_049807096.1|889282_891163_+|translational-GTPase-TypA	unknown	unknown	gnl|CDD|273597
NC_014666.1|WP_013421911.1|895658_895982_+|ferredoxin-family-protein	unknown	unknown	gnl|CDD|224069
NC_014666.1|WP_013421913.1|898373_899210_+|2,3,4,5-tetrahydropyridine-2,6-dicarboxylate-N-succinyltransferase	unknown	unknown	gnl|CDD|236996
NC_014666.1|WP_013421906.1|891669_892695_+|UDP-glucose-4-epimerase-GalE	unknown	unknown	gnl|CDD|177883
NC_014666.1|WP_013421921.1|906908_907526_-|hypothetical-protein	unknown	unknown	unknown
NC_014666.1|WP_157735292.1|904299_906126_+|leucyl-aminopeptidase	unknown	unknown	gnl|CDD|376407
NC_014666.1|WP_049806809.1|895298_895571_-|hypothetical-protein	unknown	unknown	unknown
NC_014666.1|WP_157735291.1|903285_903615_+|DivIVA-domain-containing-protein	unknown	unknown	gnl|CDD|274639
NC_014666.1|WP_013421902.1|885703_886714_+|glycosyltransferase	unknown	unknown	gnl|CDD|133029
NC_014666.1|WP_049807097.1|892751_893630_+|N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha--D-glucopyranoside-deacetylase	unknown	unknown	gnl|CDD|274584
NC_014666.1|WP_157735288.1|886745_888086_-|DUF1624-domain-containing-protein	unknown	unknown	gnl|CDD|377915
NC_014666.1|WP_041260066.1|888413_888818_+|(deoxy)nucleoside-triphosphate-pyrophosphohydrolase	unknown	unknown	gnl|CDD|239517
NC_014666.1|WP_013421909.1|894435_895302_-|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|372582
NC_014666.1|WP_049807098.1|900636_901452_+|TIGR00730-family-Rossman-fold-protein	unknown	unknown	gnl|CDD|224527

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_014666.1|WP_013421914.1|899240_900311_+|succinyl-diaminopimelate-desuccinylase	gnl|CDD|237264	PRK13007, PRK13007, succinyl-diaminopimelate desuccinylase; Reviewed.	0
NC_014666.1|WP_049807099.1|902075_902888_-|dihydropteroate-synthase	gnl|CDD|273657	TIGR01496, Dihydropteroate_synthase, dihydropteroate synthase. This model represents dihydropteroate synthase, the enzyme that catalyzes the second to last step in folic acid biosynthesis. The gene is usually designated folP (folic acid biosynthsis) or sul (sulfanilamide resistance). This model represents one branch of the family of pterin-binding enzymes (pfam00809) and of a cluster of dihydropteroate synthase and related enzymes (COG0294). Other members of pfam00809 and COG0294 are represented by model TIGR00284. [Biosynthesis of cofactors, prosthetic groups, and carriers, Folic acid].	1.98584e-87
NC_014666.1|WP_007511639.1|903899_904067_+|DUF3117-domain-containing-protein	gnl|CDD|371461	pfam11314, DUF3117, Protein of unknown function (DUF3117). This family of proteins with unknown function appears to be restricted to Actinobacteria.	7.57378e-23
NC_014666.1|WP_013421906.1|891669_892695_+|UDP-glucose-4-epimerase-GalE	gnl|CDD|177883	PLN02240, PLN02240, UDP-glucose 4-epimerase.	0
NC_014666.1|WP_013421922.1|907738_908401_-|O-methyltransferase	gnl|CDD|226607	COG4122, COG4122, Predicted O-methyltransferase [General function prediction only].	6.55592e-45
NC_014666.1|WP_013421916.1|901464_902067_+|TIGR00730-family-Rossman-fold-protein	gnl|CDD|129813	TIGR00730, LOG_family_protein_YJL055W, TIGR00730 family protein. This model represents one branch of a subfamily of proteins of unknown function. Both PSI-BLAST and weak hits by this model show a low level of similarity to and suggest an evolutionary relationship of the subfamily to the DprA/Smf family of DNA-processing proteins involved in chromosomal transformation with foreign DNA. Both Aquifex aeolicus and Mycobacterium leprae have one member in each of two branches of this subfamily, suggesting that the branches may have distinct functions. [Hypothetical proteins, Conserved].	1.298e-51
NC_014666.1|WP_049807096.1|889282_891163_+|translational-GTPase-TypA	gnl|CDD|273597	TIGR01394, GTP-binding_protein_TypA/BipA_homolog, GTP-binding protein TypA/BipA. This bacterial (and Arabidopsis) protein, termed TypA or BipA, a GTP-binding protein, is phosphorylated on a tyrosine residue under some cellular conditions. Mutants show altered regulation of some pathways, but the precise function is unknown. [Regulatory functions, Other, Cellular processes, Adaptations to atypical conditions, Protein synthesis, Translation factors].	0
NC_014666.1|WP_013421911.1|895658_895982_+|ferredoxin-family-protein	gnl|CDD|224069	COG1146, COG1146, Ferredoxin [Energy production and conversion].	2.28588e-11
NC_014666.1|WP_013421913.1|898373_899210_+|2,3,4,5-tetrahydropyridine-2,6-dicarboxylate-N-succinyltransferase	gnl|CDD|236996	PRK11830, dapD, 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional.	1.28045e-130
NC_014666.1|WP_049807098.1|900636_901452_+|TIGR00730-family-Rossman-fold-protein	gnl|CDD|224527	COG1611, COG1611, Predicted Rossmann fold nucleotide-binding protein [General function prediction only].	8.47497e-59
NC_014666.1|WP_157735292.1|904299_906126_+|leucyl-aminopeptidase	gnl|CDD|376407	pfam00883, Peptidase_M17, Cytosol aminopeptidase family, catalytic domain. The two associated zinc ions and the active site are entirely enclosed within the C-terminal catalytic domain in leucine aminopeptidase.	2.06471e-144
NC_014666.1|WP_157735291.1|903285_903615_+|DivIVA-domain-containing-protein	gnl|CDD|274639	TIGR03544, cell_division_initiation_protein_DivIVA, DivIVA domain. This model describes a domain found in Bacillus subtilis cell division initiation protein DivIVA, and homologs, toward the N-terminus. It is also found as a repeated domain in certain other proteins, including family TIGR03543.	2.83604e-06
NC_014666.1|WP_013421902.1|885703_886714_+|glycosyltransferase	gnl|CDD|133029	cd04186, GT_2_like_c, Subfamily of Glycosyltransferase Family GT2 of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.	3.95072e-25
NC_014666.1|WP_049807097.1|892751_893630_+|N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha--D-glucopyranoside-deacetylase	gnl|CDD|274584	TIGR03445, mycothiol_MshB, N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase. Members of this protein family are N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase, also called 1D-myo-inosityl-2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase, the MshB protein of mycothiol biosynthesis in Mycobacterium tuberculosis and related species. [Cellular processes, Detoxification].	1.92599e-115
NC_014666.1|WP_157735288.1|886745_888086_-|DUF1624-domain-containing-protein	gnl|CDD|377915	pfam07786, DUF1624, Protein of unknown function (DUF1624). These sequences are found in hypothetical proteins of unknown function expressed by bacterial and archaeal species. The region in question is approximately 230 residues long.	2.92857e-10
NC_014666.1|WP_041260066.1|888413_888818_+|(deoxy)nucleoside-triphosphate-pyrophosphohydrolase	gnl|CDD|239517	cd03425, MutT_pyrophosphohydrolase, The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic pyrophosphate (PPi). This enzyme requires two divalent cations for activity; one coordinates the phosphoryl groups of the NTP/dNTP substrate, and the other coordinates to the enzyme. It also contains the Nudix motif, a highly conserved 23-residue block (GX5EX7REUXEEXGU, where U = I, L or V), that functions as metal binding and catalytic site. MutT pyrophosphohydrolase is important in preventing errors in DNA replication by hydrolyzing mutagenic nucleotides such as 8-oxo-dGTP (a product of oxidative damage), which can mispair with template adenine during DNA replication, to guanine nucleotides.	1.32233e-45
NC_014666.1|WP_013421909.1|894435_895302_-|tetratricopeptide-repeat-protein	gnl|CDD|372582	pfam13369, Transglut_core2, Transglutaminase-like superfamily.	3.53376e-36

Protein sequences

>NC_014666.1|WP_013421911.1|895658_895982_+|ferredoxin-family-protein
MTYVIAEPCVDVKDRACIEECPVDCIYEGGRMLYIQPDECVDCGACEPVCPVEAIYYEDDVPEQWKPYTDTNASFFEELGSPGGASKVGALDYDPPAVAALAPQGEH
>NC_014666.1|WP_049806809.1|895298_895571_-|hypothetical-protein
MYVVRITLADIGARVVIRRRIAGPVPLTDVIGTLQSWTAGVLTVVDANGEVTRVAEADLVAAKVVPPRPDRRRPEPDPPDPEDRGLEVRR
>NC_014666.1|WP_013421909.1|894435_895302_-|tetratricopeptide-repeat-protein
MSARSRARFTDVVRRTPIDLALACQLIAAEADPEAETADVLGALDRLTDEARPVLAAKVSRARAAGGQAGDTMATSEPLDAAEALHESLGLRGGYSGLQGDYDDLRSSLLPEVLRRRHGLPILLSVIWLEVAARLGVPAYPVGLPGHMVVAIGTPRENVLVDPFAGGRRITVHDAAARVRAAGVPFSRAQLAPMNREDLLARVLGNIRVLAARADSTSTRLWAVELSLLLPHHPASLRRERGELRIRRGDYLGGARDLATFADAVDAAEPTAAAAARAAARAARSRLN
>NC_014666.1|WP_157735289.1|893882_894326_+|hypothetical-protein
MTGLGSTDRLPANPPRLFLAAAYALGLVLGFVLGLYGVVWVPEGLRLGGVFLSVGLLLALVGNTAVALLVRWLTGTRLGALVVLIGWAPVVLALGSSRPEGDLMLRATTTGYLFLALGALAPVTVAVVGTAKRGLTAFTLPPPGSSR
>NC_014666.1|WP_049807097.1|892751_893630_+|N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha--D-glucopyranoside-deacetylase
MFVHAHPDDEIIATGISIAHYAATPDTHVTLVTCTLGELGEVLVPELEHLRSDLGDQLGGYRMSELAAACVALGLDDQRYLGGPARFRDSGMMGTPGNDDPRCFWQADLTEATAELVRIVREVRPQVLVSYDSNGGYGHPDHIRAHQITVAAFTAAADPDFAPDAGEPWAPSKLYETALPKSFVQRAVERFSDVEGTPFHGATSADDVPMGVPDEVITTRIEAPEYLDAKLAALRAHRTQIAVDGFFFALADGVGQPAFTVDHYVLTRGEPVPTNGPDGTAYETDLFAGLDL
>NC_014666.1|WP_013421906.1|891669_892695_+|UDP-glucose-4-epimerase-GalE
MLVTGAAGFIGSHTCVDLLTAGYRVVGVDNFANSSPRAVERIREVAGEAGANLEFVELDVLDAVALGKLLAATPFEAVIHFAARKAVGESVAMPVEYYDTNLNATLRLVEALREHGPRRLIFSSSCSIHGDVDVLPIREDAPARPTNPYSRTKWMCEQILADVCAAQPDWHVTALRYFNPVGAHPSGLLGEDPRGIPNNLMPYLQQVAVGRREYLSVFGDDYPTADGTGVRDYIHVVDLAEGHRAALEHLDDEAGYRVVNLGTGVGTSVQQLLTAFGAACGRELPHRVVARRDGDVAALYADPSYAAETLGWRASRGLDEMCRDAWEFQRRNPGGYDGAAA
>NC_014666.1|WP_049807096.1|889282_891163_+|translational-GTPase-TypA
MPASTESAAGEVRSRNDRRNIAIIAHVDHGKTTLVDAMLRQSGAFSAHASEDLTDRVMDSMDLEREKGITILAKNTAVRYGDTTVNIIDTPGHADFGGEVERGLAMVDGVLLLVDASEGPLPQTRFVLRKALAARLPVILVINKVDRSDARIAEVVDEAYELFLDLDADEEQIDFPIVYCNAKAGRASMSRPADGDSPDSPDLKPLFDLLLETIPAPTYVEGAPLQALVTNLDASPYLGRLALCRVHNGTIRRGQQVMLCRADGTQERVKVSELLVTQALDRAPAESAGPGDIIAIAGIPDITIGETLADPEDPRPLPVITVDEPSISMTVGVNTSPLAGKSGKKLTARLVKARLDAELVGNVSIRVLPTERPDTWEIQGRGELQLAVLVELMRREDFELTVGKPQVVTREVDGKLHEPVERLTIDAPEEFLGTLTQLLAVRKGRVEQMINHGTGWIRLEYLVPARGLIGFRTEFLTETRGTGLLHHVFEGYEPWFGELRTRATGSMVADRSGPTTAYALFNLQERGTMFVPPMIDVYEGMIVGENSRADDMDVNPTKEKKLTNMRSSTGDELVRLTPHRQLTLEQALEFCREDECVEVTPATVRIRKVALLAADREKLRARRRSN
>NC_014666.1|WP_041260066.1|888413_888818_+|(deoxy)nucleoside-triphosphate-pyrophosphohydrolase
MVVAIALLDDTRRVLAARRTSPPAYAGMWEFPGGKVEPGESELAALARECREELDVEIEIGSFLGQADLASPGWRLRVWFGRILAGTPRAVEGGELRWLTVAELDDVSWLPADLPLVEAMRGRLLDPAPLTAGD
>NC_014666.1|WP_157735288.1|886745_888086_-|DUF1624-domain-containing-protein
MPELPAPASGEPHFPGVLPLPRTSPPDCPPSAVVRQRDSPAIRSAASPSPGSPTVVWVTRPRPGRIVGVDAARGAALLGMAATHVLPDFDSQGHLTWAFRIAAGRSAAAFAVLAGVALALVAARTPRPHLATLVRALCIGLVGLVLGETRTPLAVILVYYAVFFLLVLPLLRAPRWALAVVAAVTLAGEPWLSQLVRPHLPAPITANPSFGTLATAPGRLVLTLLLTGYYPALAWVGYLAVGMLVGRLDLRSARTAGWLLVGGAATAVAAKTLSWFLLGPLGGRSAILATNAVLPGIGPVGPEQASRLLAAGLYGSTPTQSWWWLAVSSPHATTPLDLAHTTGTAIALLGLALLVARLGADGRLGRILLWPLAAVGSMTLTWYTLHAALLATDALPDDPNRSYVLQVVVALVLASAWRATRRRGPLEAAVAAAARAATRRGAVATE
>NC_014666.1|WP_013421902.1|885703_886714_+|glycosyltransferase
MSTVSVVVCSHLVSRFPLLVAALDSLRTQTCGPVQVVVVVDGDDDLLKKLRDRDGDELILSTGGRTGLSNARNTGLRAVTTDLVAFLDDDATAEPTWLESLIAAVAGSPDVLGVGGRTVPAWESRQPEWFPDELLWTVGCSHRGLPKVRQPVRNVFGGCALFRRGLFDEVGGFDDRLGRKAKGAAGCEETEFCIRAQRLHRGGRFLYEPAAVIHHRVPRERSSASYVLRRCWEEGRSKAILRMITRDEGGPVRVGRRGSALGPEQDFLLRVLPAGVVDGLRQAVHGRPAAAGRALLLLVGSVATVVSFAAAALQSAGRGRVAAPAPRPVAAHARDL
>NC_014666.1|WP_013421913.1|898373_899210_+|2,3,4,5-tetrahydropyridine-2,6-dicarboxylate-N-succinyltransferase
MSTSSFVSPLDSGIDELWARRADITPADADARKAVVAAVDAIDAGEARVAFVAADGSVVVDERAKHAILLSFKVLPMGESNAGDFRYNDRMPLKTRFDGVRVVPGAIVRWGAHIAPGAVLMPSYTNIGGFVDSGSMVDTWATVGSCAQVGKNVHLSGGVGLGGVLEPPNAVPVIVEDDAFVGSRSMIIDGARVHRGAKLGAGSILTASTHVFDANTGEEYPRGEIPERAVAVGASRVKSFPGGDFAMPCMLVLRTLAEGQIHDKLALNDILREHGVAT
>NC_014666.1|WP_013421914.1|899240_900311_+|succinyl-diaminopimelate-desuccinylase
MGLDVAVPAGELTGALVDFASVSGSEGPLADAVEAALVGLPGLTVDRDGDAVVARTSLGRPTRVVLAGHLDTVPIADNVPSRREGDRLYGCGTSDMKSGVAVMLHLAATVAAESLVHDLTWVFYDNEEVDASRNGLRRLAERHRDWLEGDLAVLMEPTGGEIEAGCQGTLRVIATLPGRRAHSARSWLGDNAIHRAGDLLTRLAAYQPRTVEIDGCAYREGLSAVRISGGVAGNVIPDRCEVTINFRFAPDRDVAGALAHVQEVLAGYELELTDSSGGALPGLSAPAAAAFVTATGRQPRAKYGWTDVARFAALGIPALNYGPGDPNLAHTRDEYVELPLVEEAERVLRAYLTTRS
>NC_014666.1|WP_049807098.1|900636_901452_+|TIGR00730-family-Rossman-fold-protein
MGAPVPPNDGPRRYEPGEFPTPPPEQRRGPQLARRSQIRHSTSDERLLANRGSGDFTHADPWRVLRIQSEFVEGFDLLADLPRAVTVFGSARVPRDHPDYEVGRRLGAALVEAGFAVITGGGPGAMEAANRGAQEAGGLSVGLGIELPFEQKLNDWVDLGVSFRYFFVRKTMFVKYAEAFVILPGGLGTLDELFEALTLVQTGKVRRFPVVLLGTDYWRGLLDWLRGTVVGTARMKDTDLDLFSLTDDVDEAVRLVVDGIASSTPPQPRGR
>NC_014666.1|WP_013421916.1|901464_902067_+|TIGR00730-family-Rossman-fold-protein
MRICVYCSSSERIDPGYVLLAGQVGTELAARGHSLVSGGGSISCMGAVARSARAGGASTLGVIPRKLLDLEVSDTDADELIVTETMRERKAIMDERADAFLALPGGLGTLEELFEIWVAAMLGMHAKPIVVLDPDGVFAHLHTLVDGLVDRGFVRPEARALLRWSTTPAEALDFLEAAGVGSAVNPTVGEAIEAAAPPID
>NC_014666.1|WP_049807099.1|902075_902888_-|dihydropteroate-synthase
MAIVNRTPDSFFDKGATYGESEALAAVERAIAEGAGIIDIGGVKAAPGAEISAAEELRRIGGFVARVRAAHPDVVISVDTYRAEVGRVVVAEGADLLNDAWGGVEPELAEVAAAGGVGLVCTHAGHLPPRTRPHRMTYQDVVADIVATTCGLAERAVALGVRPDAVVIDPGHDFGKNSRHSMEATRRTDELVATGWPVLMAMSNKDFVGEALDTPVEERLEGTLAATAVSAWLGARIFRAHQVAATRRALRMVAAIRGDADLTVARRGLA
>NC_014666.1|WP_157735291.1|903285_903615_+|DivIVA-domain-containing-protein
MAPAPPDAAPTGLPAAGPVGAREVGGVRLNLAFRGYRMAEVDALLARLAGELAWRDEELARRDDELVRLATFAHADATQGPAGGAEGATPGASPGTPTDGHTQWTGLDG
>NC_014666.1|WP_007511639.1|903899_904067_+|DUF3117-domain-containing-protein
MAAMKPRTGDGPLEVTKEGRGIVMRVPLEGGGRLVVELTADEASALGDALKTAVG
>NC_014666.1|WP_157735292.1|904299_906126_+|leucyl-aminopeptidase
MRTESGSGRVPVVTLRPGGPAAPESSVLAVVVLSSAQADTADGTIAAAGGPAVGDQNGASPAGTTVGIVSPAAAGACADLGLDLDTLLTAHNVGGDAGSVLVVPLARAEAPTRLLLVGAGGGGLGEWRTAGAALARRAGSGDRVVALVADPEPAQLAALTEGLALAAYKQPKGPGEPIATDDLDADGDHTDGAERGAADVEAGDLSAGTTDLTGAERDADGAAEPAGETDELPPAAAESAPAAAGGPGLDEVIVWYSGALTSTELAEATEAVRRASVLARAVLTARDLINTPSLVKSPEWLARRAMAAARAAGLDAALLDATELAAGGFGGLTHVGGGSSRPPYLVELRYQGPPAEDGPAARHRVLVGKGITFDSGGLSLKPPGSMTSMKTDMSGAAAVLATMAALPELGAPGKVTGLLCIAENMIGGAAVRPGDVISCWGGTTVEVLNTDAEGRLVLADGLAYAAGALGAEVLVDLATLTGAVSIALGRRTAGLFASDDALAGELTAAAELAGERVWRLPLVEEYRPALESTVADLANMGSALNVGGGSIAAALFLREFTAGLPWAHLDIAGTARSDADDAEITRGGTGWGVRTLLRWLTADPTLAE
>NC_014666.1|WP_013421921.1|906908_907526_-|hypothetical-protein
MSGSRRSERDRGSGNASMAVFLVVVAVVACLAGYGVRKVTLSDGGSGTSTPTTASTATATPTAPSALTGLTAEVVAIKLAGTGLPLRTVRVYTAGSDPNQLFGKPGGYTSKIEFADARTGVNLNGVTSQDPVEIGGSIEVFADATSADARLQQLRQISAAGGQLTQEVDFRQDGVVLRLSRYLTQAQAQAYETALTSLATPPPAA
>NC_014666.1|WP_013421922.1|907738_908401_-|O-methyltransferase
MPDTDIGAQDRAAAFAEGFLLEDPILRAARARAEEVGILPISPGAGAVLRFLAASVGARAVVEIGTGTGVSGTWLLRGMRPDGTLTTIDVEAEHLRLARRTYADAGMAPNRSRLITGRGLDVLPRLTDGAYDLVFCDADRREGTEYLIQALRLLRPGGVVAFAGILIDGLAADPAVRNPEIMAIRELATAVRDDARLTPMLLNSGDGLLVAAVAKSYPVG

Crispr_ID: NC_014666_2

• CRISPR_ID: NC_014666_2
• CRISPR_location: 1305253-1305342
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_014666_2

Consensus_repeat	Method
GGGCCGAGCCGGGTCGCGGCGTCG	CRISPRCasFinder

spacers of NC_014666_2

>2.1|1305277|42|NC_014666|CRISPRCasFinder
TCGTCCCAGCCGCCCCGGGGCCCGCTCGGGCCGCCGGCCGTG

CRISPR arrays and Neighbor proteins around NC_014666_2

CRISPR arrays

The CRISPR arrays of NC_014666_2

>merge|NC_014666|2|1305253-1305342|CRISPRCasFinder
GGGCCGAGCCGGGTCGCGGCGTCGTCGTCCCAGCCGCCCCGGGGCCCGCTCGGGCCGCCGGCCGTGGGGCCGAGCCGGGTCGCGTCGTCG

>NC_014666|2|2|1305253-1305342|CRISPRCasFinder
GGGCCGAGCCGGGTCGCGGCGTCG	TCGTCCCAGCCGCCCCGGGGCCCGCTCGGGCCGCCGGCCGTG
GGGCCGAGCCGGGTCGCGTCGTCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_014666.1|WP_041258888.1|1310741_1312949_-|RNA-degradosome-polyphosphate-kinase	unknown	unknown	gnl|CDD|235469
NC_014666.1|WP_013422220.1|1293848_1294529_+|Crp/Fnr-family-transcriptional-regulator	unknown	unknown	gnl|CDD|223736
NC_014666.1|WP_013422223.1|1297513_1297765_-|hypothetical-protein	unknown	unknown	unknown
NC_014666.1|WP_013422218.1|1292113_1293040_+|branched-chain-amino-acid-transaminase	unknown	unknown	gnl|CDD|235841
NC_014666.1|WP_013422224.1|1298161_1298941_+|fumarylacetoacetate-hydrolase-family-protein	unknown	unknown	gnl|CDD|223257
NC_014666.1|WP_041260177.1|1318156_1319167_+|NAD(P)-dependent-glycerol-3-phosphate-dehydrogenase	unknown	unknown	gnl|CDD|234629
NC_014666.1|WP_013422236.1|1316219_1317044_-|cyclase-family-protein	unknown	unknown	gnl|CDD|224790
NC_014666.1|WP_013422229.1|1306697_1307606_-|IclR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224332
NC_014666.1|WP_013422226.1|1300507_1302241_+|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl|CDD|223715
NC_014666.1|WP_013422231.1|1309224_1309821_+|3-isopropylmalate-dehydratase-small-subunit	unknown	unknown	gnl|CDD|179314
NC_014666.1|WP_013422227.1|1302322_1304173_-|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|372616
NC_014666.1|WP_013422232.1|1310368_1310650_+|HU-family-DNA-binding-protein	unknown	unknown	gnl|CDD|259853
NC_014666.1|WP_013422225.1|1299890_1300187_-|hypothetical-protein	unknown	unknown	unknown
NC_014666.1|WP_013422221.1|1294930_1296535_+|citramalate-synthase	unknown	unknown	gnl|CDD|237068
NC_014666.1|WP_013422219.1|1293305_1293692_+|CBS-domain-containing-protein	unknown	unknown	gnl|CDD|341405
NC_014666.1|WP_157734825.1|1313245_1314301_+|transglutaminase-family-protein	unknown	unknown	gnl|CDD|224224
NC_014666.1|WP_157734826.1|1317091_1317832_-|2-phospho-L-lactate-guanylyltransferase	unknown	unknown	gnl|CDD|274643
NC_014666.1|WP_041260178.1|1319163_1320522_-|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	unknown	unknown	gnl|CDD|236486
NC_014666.1|WP_013422217.1|1290810_1291842_+|3-isopropylmalate-dehydrogenase	unknown	unknown	gnl|CDD|179579
NC_014666.1|WP_013422230.1|1307705_1309118_+|3-isopropylmalate-dehydratase-large-subunit	unknown	unknown	gnl|CDD|235490

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_014666.1|WP_041258888.1|1310741_1312949_-|RNA-degradosome-polyphosphate-kinase	gnl|CDD|235469	PRK05443, PRK05443, polyphosphate kinase; Provisional.	0
NC_014666.1|WP_013422220.1|1293848_1294529_+|Crp/Fnr-family-transcriptional-regulator	gnl|CDD|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	7.12977e-40
NC_014666.1|WP_013422218.1|1292113_1293040_+|branched-chain-amino-acid-transaminase	gnl|CDD|235841	PRK06606, PRK06606, branched-chain amino acid transaminase.	4.53233e-167
NC_014666.1|WP_013422231.1|1309224_1309821_+|3-isopropylmalate-dehydratase-small-subunit	gnl|CDD|179314	PRK01641, leuD, 3-isopropylmalate dehydratase small subunit.	2.24492e-124
NC_014666.1|WP_041260177.1|1318156_1319167_+|NAD(P)-dependent-glycerol-3-phosphate-dehydrogenase	gnl|CDD|234629	PRK00094, gpsA, NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.	5.61817e-163
NC_014666.1|WP_013422236.1|1316219_1317044_-|cyclase-family-protein	gnl|CDD|224790	COG1878, COG1878, Kynurenine formamidase [Amino acid transport and metabolism].	1.29476e-47
NC_014666.1|WP_013422229.1|1306697_1307606_-|IclR-family-transcriptional-regulator	gnl|CDD|224332	COG1414, IclR, Transcriptional regulator [Transcription].	1.453e-42
NC_014666.1|WP_013422226.1|1300507_1302241_+|HAMP-domain-containing-histidine-kinase	gnl|CDD|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	5.62806e-37
NC_014666.1|WP_157734826.1|1317091_1317832_-|2-phospho-L-lactate-guanylyltransferase	gnl|CDD|274643	TIGR03552, F420_cofC, 2-phospho-L-lactate guanylyltransferase. Members of this protein family are the CofC enzyme of coenzyme F420 biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	1.45329e-34
NC_014666.1|WP_013422227.1|1302322_1304173_-|class-I-SAM-dependent-methyltransferase	gnl|CDD|372616	pfam13489, Methyltransf_23, Methyltransferase domain. This family appears to be a methyltransferase domain.	7.52202e-24
NC_014666.1|WP_013422232.1|1310368_1310650_+|HU-family-DNA-binding-protein	gnl|CDD|259853	cd13831, HU, histone-like DNA-binding protein HU. This subfamily includes HU and HU-like domains. HU is a conserved nucleoid-associated protein (NAP) which binds non-specifically to duplex DNA with a particular preference for targeting nicked and bent DNA. It is highly basic and contributes to chromosomal compaction and maintenance of negative supercoiling, thus often referred to as histone-like protein. HU can induce DNA bends, condense DNA in a fiber and also interact with single stranded DNA. It contains two homologous subunits, alpha and beta, typically forming homodimers (alpha-alpha and beta-beta), except in E. coli and other enterobacteria, which form heterodimers (alpha-beta). In E. coli, HU binds uniformly to the chromosome, with a preference for damaged or distorted DNA structures and can introduce negative supercoils into closed circular DNA in the presence of topoisomerase I. Anabaena HU (AHU) shows preference for A/T-rich region in the center of its DNA binding site.	4.85342e-39
NC_014666.1|WP_013422224.1|1298161_1298941_+|fumarylacetoacetate-hydrolase-family-protein	gnl|CDD|223257	COG0179, MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism].	4.64294e-96
NC_014666.1|WP_013422221.1|1294930_1296535_+|citramalate-synthase	gnl|CDD|237068	PRK12344, PRK12344, putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional.	0
NC_014666.1|WP_013422219.1|1293305_1293692_+|CBS-domain-containing-protein	gnl|CDD|341405	cd09836, CBS_pair_arch, Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).	3.55648e-26
NC_014666.1|WP_157734825.1|1313245_1314301_+|transglutaminase-family-protein	gnl|CDD|224224	COG1305, COG1305, Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism].	4.63812e-28
NC_014666.1|WP_041260178.1|1319163_1320522_-|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	gnl|CDD|236486	PRK09369, PRK09369, UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated.	0
NC_014666.1|WP_013422217.1|1290810_1291842_+|3-isopropylmalate-dehydrogenase	gnl|CDD|179579	PRK03437, PRK03437, 3-isopropylmalate dehydrogenase; Provisional.	0
NC_014666.1|WP_013422230.1|1307705_1309118_+|3-isopropylmalate-dehydratase-large-subunit	gnl|CDD|235490	PRK05478, PRK05478, 3-isopropylmalate dehydratase large subunit.	0

Protein sequences

>NC_014666.1|WP_013422227.1|1302322_1304173_-|class-I-SAM-dependent-methyltransferase
MRGWFAITTGALVLANGARLRRRLHGLDRTAPSTEAVATSHAFLVATGVQLSGEARRAASAHARREGLDVLDLVPADLPPERLLDLARTVRVARYRADRFAAGQGAGQALLVDRSVLARAGINEREDYTPVELLKIVRRLKQYAPATTGLAIAPGLKAASLGGAQRLRLRAAGYQHPYQPVAYLPAVRTAAVTAACVTTPGWGLLALALSALQPAAVAAGRVSPGSRNVVATSARRLASWPAFAVEAARTRRAGGAAPDLDARRRRAEYQAEISTETAKHFEQRRDRCPWCGSTALETRTSAADVILRKPGRFSYDQCDACAHIFLNPCLSPAGLDFYYRDFYDGLNADQAEGMFAASDLGYRSRARLLPAGAGATRWLDVGGGHGHFCLVAGGLLPNVRFDAVDQGDGIAEAQRRGWVRHAYRRMFPDLASEIAGRYDVISMFHYLEHTLDPRRELDAAAAALPPAGHLLIEVPHAHGPSFALFRGFWVGLCPPQHLHLISPDELVRALAERGLRTVKVEFGPAHIFGDATSAVYYLTQKLQPDPTLPWLPYEATAWRRARRLGALTATAPLFPLAALVDAMMLPYLLTGRRANVYRVVARKDGEPSVLSTDTKG
>NC_014666.1|WP_013422226.1|1300507_1302241_+|HAMP-domain-containing-histidine-kinase
MSAAGPPFGERARRRHERARAARTRHVTGHPRRGAADRRPADPTSQSTGGSLSGRASGWVSSLVPHGHRLTLEDWNARHRLLKWVLALHLPVIVGYAQLHHFDTMHGIAAASPSILLFGAAALPGLRRVRALAASLGLLCCSVVFVHLSDGLGPMYFHFFVVVALIALYEDWSVYALAIGFVFVANLAMRYLVTPGALTDYARHSALMLAAMHAAFIVALAGAQVVFWRYNQQERSRTERYRHQLYEGQQSLMARLEETDRIRTDLVATVSHEFRTPLAGIRGNLLTLRRRRHRMSEAQVDDMLDLALGSSERLSRLLENMLTAATATGIDDTTVSDLPEVVYEALGSLRNAALVNAVTVDLPDHLPVRMSREALHQVVANLVDNALVHSWPGAPVRLIAGRVGDEVVLRVRNPGPDLDKETIARLFEPFTQRDGSATRPTDGAGMGLYVVRRLVEVHGGRLRMTSDGGEINVEVDMWAAELPLPTADPTMLPRLPDLPRLRAEGLVEREPFIPAPSSPPLAVRRPRWDQPGRGYPNADEADLTGLGGSGLGGAGLGGPRGRASAWPADDLPLDRSG
>NC_014666.1|WP_013422225.1|1299890_1300187_-|hypothetical-protein
MPQVALTLASVPARLSSHSGPAIAPCPAADAAPVPVTLPAPAEPSVQVARAHLRLVTSATAVTEIDEIHGHGGPASCHCRACAMARHPASLPRLSVVR
>NC_014666.1|WP_013422224.1|1298161_1298941_+|fumarylacetoacetate-hydrolase-family-protein
MRIARFTDGSEPAFGVVEGSVERGEATVAALTPHPFGPFQFTGARRPLGEVRLLAPVLPSKVLAVGKNYADHVREMGGDAPPDKPILFLKPSTAVVGPGDPIVHPDPTSRMDYEGELAIVIGRLCRDVPEERAMSVVLGFTCANDVTMREQQASDGQWTRAKGHDSHCPLGPWIETDLDAAGAGLRTTLDGEVRQNSTTAHLIHGIPKLIAYMSAAMTLLPGDVLLTGTPAGVGPMRPGQTVAVTVDGIGTLTNPVTAR
>NC_014666.1|WP_013422223.1|1297513_1297765_-|hypothetical-protein
MTEAVYDVGAPEPKPIDEELSVKLGHLAEDAILRGKPNGAERCDNCLYYLDTDKDITYCWHPKLRVLVGGDWWCQWWEEIPED
>NC_014666.1|WP_013422221.1|1294930_1296535_+|citramalate-synthase
MRPYDPESLHIYDTTLRDGTQQEGLSLSVADKLAVARHLDDLGVGFIEGGWPGSNPKDAEFFRRAQTELNLRGAKLAAFGSTRRASKTAADDPQVAALREAGTPVVCLVAKSDRRHVERALRTTLAENLAMIRDTVEHLRAEGKRVFVDAEHFFDGYRVDEAYGLEVVRTAAEAGAEVVVLCDTNGGMLPTQIGDTVRAVLDASGARLGIHCHDDSGCAVANSLVAVQAGVTHVQGAANGYGERCGNANLFTVVAGLETKLATPVLPAGRLRELVRVSHAIDELTNSAPDTHRPYVGASAFAHKGGLHASAVKIDPDMYQHIDPAVVGNDMRMLVSELAGRATIELKGREFGLDLSDEKEALGRIVELVKEREASGFAYEAAEASFELLLRDEVYGPERYFTLDSWRVIVEQRPDGEVVSEATVKLETRGERHVSTAEGNGPVNALDKALREALAKAYPGLKAVDLTDFKVRILDGQEGSGAITRVLVETTDGQTRWDTIGVDENIIAASWQALQDAVTYGLRRQNEVPDPDAV
>NC_014666.1|WP_013422220.1|1293848_1294529_+|Crp/Fnr-family-transcriptional-regulator
MLDDDEAVALLRATTLLKELDEEDLRRLAARAVTRRYRRGQVVFTEGEPADTLLVVAQGRLKVLTKADDGRDHVLNIHGPRETIGELNIVEPGTRSASVEALEPSTALVLDRTAVWELVKERPAVAEQLIRALVAHVRRLTGANADLVFLDLPRRVAKLLLMRAREASRPVIELGLTQTEIASLLGGSRQSVNQALREFERRSWILSEGQTITILQLDRLRRFAGD
>NC_014666.1|WP_013422219.1|1293305_1293692_+|CBS-domain-containing-protein
MRVSDGMSALVLIIGPGHTLRQAARLMAGRGCGAAVVLDTDGAGYGILTERDVLLALAAGKDPDVEIAADHLTRDLVFADPEWSLDTAADAMLRGGFRHLVVTEGGIVAGVLSMRDVVRCWNQQRVSA
>NC_014666.1|WP_013422218.1|1292113_1293040_+|branched-chain-amino-acid-transaminase
MAITPTSKIWMNGEFVAWDDAKIHVLTPTLHYGWGVFEGIRAYETPHGSAVFRLTDHIARLYRSAKIYMMEPDFTEAQFVQAAKDTVVANDIQSCYLRPLIYLGYGEMGLNPLPSKVESMIAVWPWGAYLGEEALEKGCRVIISSWRRNDVNITPPAAKATGQYLNSSLAKVAAIKAGYDEAILTSPTGHIADGSGENVFIVAGRTLITPPLTDGALGGITRASVMQIAADQGYEVVEKHIVRTDLYLADEAFFTGTAAEIVPIAEVDDRAVGAGRPGPVTKEIAEIFHQATTGQLDRYKTWNEFVAD
>NC_014666.1|WP_013422217.1|1290810_1291842_+|3-isopropylmalate-dehydrogenase
MKLAVIGGDGIGPEVVAEGLRVLRAVHDKVETTDYDLGARRWHETGETLPDTVLDELRGHDAILLGAVGDPNVPSGVLERGLLLRLRFELDHHVNLRPVKLYPGVTSPLAGDPTIDMIVVREGTEGPYAGAGGVLRKGTPHEIATEESINTRFGVERVVRDAFARAQRRPRRKLTLVHKNNVLTKAGDLWSRTVTEVAAEFPEITVEYQHADAASMFFITDPGRFDVVVTDNLFGDIITDIGAAVTGGIGLAASGNLDPSGAHPSMFEPVHGSAPDIAGKGVADPTATVASVAMLLDHLGLTAEAAKVEKAVAGSLAARAASAGQPLSTREVGEDLAQRAVAN
>NC_014666.1|WP_013422229.1|1306697_1307606_-|IclR-family-transcriptional-regulator
MEQRNPSPGPDAAGASSGVGVLDKAALVLAAVEEGPASLGELVTRTGLSRATAHRLAVALETHRLVARDGAGRFVAGPRLAAGSAVAALWPLPWRLLQAAPEVLAELRDSTGESTQLYVRRGAERVCVAAAEHGSGLRDTVPVGAILPMTAGSGAQVLLAFAAPEDGPAGSRPAATGRGGGGGGPVAPAGAAFGAEVLAGVRARGWAQSAGEREAGLASVSAPVRDAAGTVVAALSMSGPDGRLTRSPGELFGAIVAAAADRLSTIAGYSETNNPRATKRVTGSTSLTPGTTPDGLSADAKA
>NC_014666.1|WP_013422230.1|1307705_1309118_+|3-isopropylmalate-dehydratase-large-subunit
MTLKGEGRTLAEKVWDAHVVRRADGEPDLLYIDLHLVHEVTSPQAFEALRLAGRSVRRPDLTIATEDHNVPTTDTLLPIADPVSRAQVEALRKNCADFGVRLHPMNDPGQGIVHVVGPQLGLTQPGMTVVCGDSHTATHGAFGALAFGIGTSQVEHVLATQTLPQARPKTMAITVDGALPDGVTAKDLILAVIAEIGTGGGQGYVLEYRGEAVRTLSMEGRMTVCNMSIEAGARAGMIAPDETTFEFLKGRPHAPTGADWDAAVAYWKTLATDEDAVFDREVVIDAASLSPFVTWGTNPGQGSPLSAAVPDPASFADAGERAAAERALAYMGLTAGTPLRDVPVDTVFIGSCTNGRLSDLRAAADILRGRAVADGVRVLVVPGSMQVKADAEAEGLDEVFRAAGAEWRSAGCSMCLGMNPDTLKPGERSASTSNRNFEGRQGQGGRTHLVSPQVAAATAVTGRLAAPADL
>NC_014666.1|WP_013422231.1|1309224_1309821_+|3-isopropylmalate-dehydratase-small-subunit
MEAFTTHTGRAVPLRRSDVDTDQIIPSDWLKRIERTGFGAGLFSEWRRDPSFVLNDPAHAGATVLLAGPNFGSGSSREHAVWALQDYGFRAVIAPKFADIFRGNSLGNGLLTVVLPVETVETLLAAVEADPAVEITVDLDAREVRGAGVVASFELDDFTRWRLMEGLDDVGLTLRHADLITTFEASRPSFLPTTTQPA
>NC_014666.1|WP_013422232.1|1310368_1310650_+|HU-family-DNA-binding-protein
MNKSQLVDRIAQQIEGGRSNATKAVDAVFHAIQEAVSAGEKVTITGFGVFERVERAERTGRNPATGEPVHVPASVVPKFRPGSEFKSSVSSNG
>NC_014666.1|WP_041258888.1|1310741_1312949_-|RNA-degradosome-polyphosphate-kinase
MAELVVTRSEQQPQRKPRSALLEPLEAPRPPLPSDLPADRFINRETSWLDFNARVLALAEDVSTPLLERAKFLAIFASNLDEFYMVRVAGLMRREATGLAVRSVDGLTPRAQLELISQNTAQLTDRAARCFTDEVVPSLEHAGISIRYWHQLTTDQQHRLHQYFHEQIFPVLTPLAVDPAHPFPYISGLSLNLAVTVRDPGDDIERFARVKVPQNVPRLIRVDLPGEHPIGQEPAGEGAEADRYACFVPLEEVIAAHLSQLFPGMEVVDSHLFRVTRNADLEVEEDEAEDLLQALERELARRRFGPAVRLEVDADIDEGLLRMLCRELEVSTRDVHRLRGLLDLSVLWALFDLDRPEFKYPPRVPVTHHSLVTESGEPADFFAVLRERDVLVHHPYDSFTTSVQRFIEQAAADPHVLAIKQTLYRTSGDSPIVDALIAAAEAGKQVVVLVEIKARFDESANIRWARELERAGCHVVYGLIGLKTHTKTALVVRQDEDGLRRYCHVGTGNYNPKTARLYEDVGLLTAEPSVGADLTDLFNVLTGYSRQTVYRSLLVAPQHMRDGLIERIEKEAAAARSGEPAGIRIKVNSLVDEELIDALYHASRDGVAIRCLVRGICALRPGVPNLSETVLVRSVLGRYLEHSRVFEFSALDEVWIGSADMMHRNLDRRVEALVRVTQDDNRAALRRLLDHGFSAEVSAWDLQPSGHWERRVTGPDDTRLSDYQGDLSAWAQNRA
>NC_014666.1|WP_157734825.1|1313245_1314301_+|transglutaminase-family-protein
MGPASTEGTGASAVQDLLPRPRPALATAAPPTAAASATAATAAVWSAEPLAVDEARLAAASLVTYRIRQRLRYTYDGPAHDLVHRLVVLPPNRHGDQTSRHGELTVSAPAARVSWERGPDGLRAATVTLDEVPGVLDFEAAAIVERGPAVTWPELPASSLTGRRLLAATALTAPDETLLAVASRLAGPDPLTTARRCCAWVFENIAYLPGSTTVGTTAAQAVAGGAGVCQDQAHVMIALCRAAGLPARYVLGHLVGDGASHAWVEVVLPDGWAPPAPGRSRGPSGPSTAGGAGAAAVALDPCHNRLADRRYVTIATGRDYHDVMPTSGVYRGSGRGLLAASQRVEIVGLEA
>NC_014666.1|WP_013422236.1|1316219_1317044_-|cyclase-family-protein
MRPVLLSHVHDPATTPVFPGDPPFTMTRAATIDADGYYLLRVSCGEHTGTHWGAPAHFDPGGLRADDLDADDLFRPAVRLDVRAAVARDPDYQVRVADLVGFEAAHGPIPAEAAVLAWTGWSDRWGTPAYPNLDERGRIHQPGFALAAVEWLVETGRLGRRGALGTDTFGPDPGLDTGYAVSRLLYRERRISLENLTNLGALPPTGAWVLAGGTRNRAGSGSPATVYGLLPASDVSRPPTTVAGAPTTVAGAPTTAVERSSGPSAASGAGRANR
>NC_014666.1|WP_157734826.1|1317091_1317832_-|2-phospho-L-lactate-guanylyltransferase
MKARAAHLGQRLPYRRDVAAGRPEGWIVVLPLKRLGAAKSRLEHPDRAALALAMATDTAAAAAAAGPDLVAGVLLVTNDPAASAAITGDGLAHPDDRPTPVVAIPDLPDRGLNPALRHGARAVARRWPGHGVAALSADLAALRPGELRAALLAAPAAGRAVLADAAGTGTVLLCAAPGSPLLPHFGVGSHARHVRSGAFDLTGPLAAAVPGLRRDVDTVADLAAARLLGVGPATRAVLASTAANAG
>NC_014666.1|WP_041260177.1|1318156_1319167_+|NAD(P)-dependent-glycerol-3-phosphate-dehydrogenase
MLTAGSWGTVFAKILADAGRRVTLVTRDEALAAAINAEHRNPRYLPGIRLPDLVRATHHPAEALAGAGLVVLAVPSQGLRAALAAWAPLVEPSAVYVSLMKGVEDGTCRRMSEVIGEVAGVGADRIAVVSGPNLAGEIAVEDPAATVVASASSATAAQVQAACWTPYLRPYTNADVVGCELGGAVKNVIALAAGMLEGLGFGLNSLASLITRGLAETTRFAVAMGADPRTLAGLAGLGDLVATCASPRSRNRTFGEKLGRGMTLDAVLAEQRQVAEGVRSCRPLLALADGLGVHMPISRQVERVLYEGLPPLEAVKELMSREPGPEFHAVAPVPPS
>NC_014666.1|WP_041260178.1|1319163_1320522_-|UDP-N-acetylglucosamine-1-carboxyvinyltransferase
MSFATAGDRHRYRIVGGQPLFGSVEVSGAKNSVTKLLVATLLTDEPCTLARVPRIVEVDVVLGMLAELGAEVEWLDDHRVRIQTARITDPSLSEMYSGVNRIPILMMGPLLHRVGEAVVPLPGGCRIGKRPVDFHLTGLRAMGAEIVEQLRSVQVKTLGLHGAHVELPFPSVGATENLLLAAVRAKGTTVISNAAVEPEVIDLILFLQQMGALVDVEVDRTIVVQGVERLHGADHTAIPDRIEVASFAAAAVATDGRVDVRGARQEHVATFLNHLRRIGGEFRVTDDGITFYKDRELTATHVQTDVHPGYMTDWQQPLVVLLTQAQGASVVHETIYEDRFGYTRQLNAMGASIALSTNCLGGKACRFAARDFEHSAVVSGPTPLVGGDLEIPDLRAGFAYVLAALVAGGASTISGTRFLERGYEDPVGKLRSIGAMIETIPVAGPTQSGAAV

Crispr_ID: NC_014666_3

• CRISPR_ID: NC_014666_3
• CRISPR_location: 1685547-1685700
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NC_014666_3

Consensus_repeat	Method
AGCTGGCCGGCGGCGTCGTAGTCGTAGC	CRISPRCasFinder

spacers of NC_014666_3

>3.1|1685575|35|NC_014666|CRISPRCasFinder
GGATCGTTCGGCCGTCGAAGTCGGTCTCGGCGACG
>3.2|1685638|35|NC_014666|CRISPRCasFinder
TCCAGCGCAGGCCCTGCGGGTTGGTGACGCTGGTC

CRISPR arrays and Neighbor proteins around NC_014666_3

CRISPR arrays

The CRISPR arrays of NC_014666_3

>merge|NC_014666|3|1685547-1685700|CRISPRCasFinder
AGCTGGCCGGCGGCGTCGTAGTCGTAGCGGATCGTTCGGCCGTCGAAGTCGGTCTCGGCGACGAGCTGGCCGGCGGCGTCGTACTCGTAGCTCCAGCGCAGGCCCTGCGGGTTGGTGACGCTGGTCAGCCGGAGCTCGGTGTCGTAGCCGAAGG

>NC_014666|3|3|1685547-1685700|CRISPRCasFinder
AGCTGGCCGGCGGCGTCGTAGTCGTAGC	GGATCGTTCGGCCGTCGAAGTCGGTCTCGGCGACG
AGCTGGCCGGCGGCGTCGTACTCGTAGC	TCCAGCGCAGGCCCTGCGGGTTGGTGACGCTGGTC
AGCCGGAGCTCGGTGTCGTAGCCGAAGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_014666.1|WP_157734837.1|1689459_1689963_-|hypothetical-protein	unknown	unknown	unknown
NC_014666.1|WP_013422524.1|1668754_1669075_+|N-acetyltransferase	unknown	unknown	gnl|CDD|379642
NC_014666.1|WP_157735323.1|1688821_1689454_-|hypothetical-protein	unknown	unknown	unknown
NC_014666.1|WP_157735322.1|1672322_1673306_-|hypothetical-protein	unknown	unknown	unknown
NC_014666.1|WP_013422539.1|1691112_1691760_-|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|378968
NC_014666.1|WP_013422535.1|1688383_1688680_-|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl|CDD|377587
NC_014666.1|WP_013422530.1|1674626_1676753_+|potassium-transporter-TrkA	unknown	unknown	gnl|CDD|367001
NC_014666.1|WP_013422544.1|1696109_1697123_-|LuxR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|197715
NC_014666.1|WP_157734838.1|1691905_1693816_+|DNA-polymerase-I	unknown	unknown	gnl|CDD|237876
NC_014666.1|WP_013422541.1|1693918_1694362_-|oxidoreductase	unknown	unknown	gnl|CDD|381284
NC_014666.1|WP_013422527.1|1671635_1672259_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228
NC_014666.1|WP_013422538.1|1690358_1691111_-|ATPase	unknown	unknown	gnl|CDD|176908
NC_014666.1|WP_013422532.1|1678106_1682666_+|FHA-domain-containing-protein	unknown	unknown	gnl|CDD|274860
NC_014666.1|WP_013422526.1|1670565_1671600_-|zinc-binding-dehydrogenase	unknown	unknown	gnl|CDD|176203
NC_014666.1|WP_013422531.1|1677016_1677808_+|DUF4389-domain-containing-protein	unknown	unknown	gnl|CDD|379561
NC_014666.1|WP_013422533.1|1683145_1683469_-|hypothetical-protein	unknown	unknown	unknown
NC_014666.1|WP_013422543.1|1695201_1696068_+|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|224044
NC_014666.1|WP_013422529.1|1673548_1674364_-|siderophore-interacting-protein	unknown	unknown	gnl|CDD|99790
NC_014666.1|WP_013422525.1|1669141_1670560_-|sulfotransferase	unknown	unknown	gnl|CDD|379204
NC_014666.1|WP_013422542.1|1694385_1694793_-|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl|CDD|378915

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_014666.1|WP_013422524.1|1668754_1669075_+|N-acetyltransferase	gnl|CDD|379642	pfam14542, Acetyltransf_CG, GCN5-related N-acetyl-transferase. This family of GCN5-related N-acetyl-transferases bind both CoA and acetyl-CoA. They are characterized by highly conserved glycine, a cysteine residue in the acetyl-CoA binding site near the acetyl group, their small size compared with other GNATs and a lack of of an obvious substrate-binding site. It is proposed that they transfer an acetyl group from acetyl-CoA to one or more unidentified aliphatic amines via an acetyl (cysteine) enzyme intermediate. The substrate might be another macromolecule.	1.55475e-28
NC_014666.1|WP_013422535.1|1688383_1688680_-|WXG100-family-type-VII-secretion-target	gnl|CDD|377587	pfam06013, WXG100, Proteins of 100 residues with WXG. ESAT-6 is a small protein appears to be of fundamental importance in virulence and protective immunity in Mycobacterium tuberculosis. homologs have been detected in other Gram-positive bacterial species. It may represent a novel secretion system potentially driven by the pfam01580 domains in the YukA-like proteins.	2.48858e-06
NC_014666.1|WP_013422543.1|1695201_1696068_+|ATP-binding-cassette-domain-containing-protein	gnl|CDD|224044	COG1119, ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism].	8.90663e-71
NC_014666.1|WP_013422526.1|1670565_1671600_-|zinc-binding-dehydrogenase	gnl|CDD|176203	cd08241, QOR1, Quinone oxidoreductase (QOR). QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR acts in the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site, and a structural zinc in a lobe of the catalytic domain. NAD(H)-binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	2.19962e-83
NC_014666.1|WP_013422530.1|1674626_1676753_+|potassium-transporter-TrkA	gnl|CDD|367001	pfam02254, TrkA_N, TrkA-N domain. This domain is found in a wide variety of proteins. These protein include potassium channels, phosphoesterases, and various other transporters. This domain binds to NAD.	1.47368e-16
NC_014666.1|WP_013422544.1|1696109_1697123_-|LuxR-family-transcriptional-regulator	gnl|CDD|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	4.46731e-11
NC_014666.1|WP_157734838.1|1691905_1693816_+|DNA-polymerase-I	gnl|CDD|237876	PRK14975, PRK14975, bifunctional 3'-5' exonuclease/DNA polymerase; Provisional.	1.99635e-61
NC_014666.1|WP_013422541.1|1693918_1694362_-|oxidoreductase	gnl|CDD|381284	cd14775, TrHb2_O-like, Truncated hemoglobins, group 2 (O); uncharacterized subgroup. The M- and S families exhibit the canonical secondary structure of hemoglobins, a 3-over-3 alpha-helical sandwich structure (3/3 Mb-fold), built by eight alpha-helical segments. Truncated hemoglobins (TrHbs, 2/2Hb, or 2/2 globins) or the T family globins adopt a 2-on-2 alpha-helical sandwich structure, resulting from extensive and complex modifications of the canonical 3-on-3 alpha-helical sandwich that are distributed throughout the whole protein molecule. TrHbs are classified into three main groups based on their structural properties and named after Mycobacterium sp. genes glbN, glbO, and glbP: TrHb1s (N), TrHb2s (O) and TrHb3s (P).	1.6829e-45
NC_014666.1|WP_013422527.1|1671635_1672259_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	6.10868e-09
NC_014666.1|WP_013422538.1|1690358_1691111_-|ATPase	gnl|CDD|176908	cd08899, SRPBCC_CalC_Aha1-like_6, Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins. SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.	2.12896e-06
NC_014666.1|WP_013422532.1|1678106_1682666_+|FHA-domain-containing-protein	gnl|CDD|274860	TIGR03928, T7_EssCb_Firm, type VII secretion protein EssC, C-terminal domain. This model describes the C-terminal domain, or longer subunit, of the Firmicutes type VII secretion protein EssC. This protein (homologous to EccC in Actinobacteria) and the WXG100 target proteins are the only homologous parts of type VII secretion between Firmicutes and Actinobacteria. [Protein fate, Protein and peptide secretion and trafficking].	1.80292e-92
NC_014666.1|WP_013422539.1|1691112_1691760_-|helix-turn-helix-transcriptional-regulator	gnl|CDD|378968	pfam12840, HTH_20, Helix-turn-helix domain. This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.	5.48174e-11
NC_014666.1|WP_013422531.1|1677016_1677808_+|DUF4389-domain-containing-protein	gnl|CDD|379561	pfam14333, DUF4389, Domain of unknown function (DUF4389). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 104 and 223 amino acids in length. There is a single completely conserved residue R that may be functionally important.	9.88859e-11
NC_014666.1|WP_013422529.1|1673548_1674364_-|siderophore-interacting-protein	gnl|CDD|99790	cd06193, siderophore_interacting, Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from transferrin and lactoferrin for bacterial uptake, contributing to pathogen virulence. Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport mechanism of photosystem I. FNR transfers electrons from reduced ferredoxin to FAD (forming FADH2 via a semiquinone intermediate) and then transfers a hydride ion to convert NADP+ to NADPH. FNR has since been shown to utilize a variety of electron acceptors and donors and has a variety of physiological functions including nitrogen assimilation, dinitrogen fixation, steroid hydroxylation, fatty acid metabolism, oxygenase activity, and methane assimilation in a variety of organisms. FNR has an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) flavin sub-domain which vary in orientation with respect to the NAD(P) binding domain. The N-terminal moeity may contain a flavin prosthetic group (as in flavoenzymes) or use flavin as a substrate. Because flavins such as FAD can exist in oxidized, semiquinone (one-electron reduced), or fully reduced hydroquinone forms, FNR can interact with one and two electron carriers. FNR has a strong preference for NADP(H) vs NAD(H).	2.26831e-80
NC_014666.1|WP_013422525.1|1669141_1670560_-|sulfotransferase	gnl|CDD|379204	pfam13469, Sulfotransfer_3, Sulfotransferase family.	6.43368e-37
NC_014666.1|WP_013422542.1|1694385_1694793_-|nuclear-transport-factor-2-family-protein	gnl|CDD|378915	pfam12680, SnoaL_2, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	1.51695e-10

Protein sequences

>NC_014666.1|WP_013422533.1|1683145_1683469_-|hypothetical-protein
MDLIDEVFDATIGATDDILFARDALRRVDPGWLAIALRPLIARHFKEPTEPIDWLDYRCVADLLDDLKQINLLNIFIKWASEVDDPEVQEVVDDYRDLLGQETPESL
>NC_014666.1|WP_013422532.1|1678106_1682666_+|FHA-domain-containing-protein
MIIRVTVRHASTGASRDVEITAEPATTLASVLAALPLPAAGRPCYIGERLLDPTVTVGESPLLQGATVSIGAPGPRQRALAAGAVGALRVLDGPDVGVVAWLPPGRRTAARTGDADLVLHCEQASREHVEIEIDVLGRAAAVDVGSFNGTFLDGERLTEPAVLSAGSLLQVGSDRLEWVSLPAAGLITKPGGDGRLDFDRTFISPPAVHPAEIVLPTPPTRPPTSRLGAWLSALLPVAMGLVLAVVTHRTLVLLMCLLGPLGVIGTQMSDRRQRRLDRGRYEEATAGVARGLGTRIADEERTRRAQAPDLVEVTLAATGASRHLWPRNADSPDGLSLRLGVGTAAPSFVIRGERWAGFREPELRGVPLTVDLRAVGVLGIVGPAATAGSLARWLLIQLGTLRSPDDLRLVLITSNDGADLSWATWLPHTYDSEAGDLPCWVGNTASTRADRVRELRELISIRLAERRGNTNVRHEMDVVVLLDGALALRNLPGMKAVLRDGPEAGVYVLAVDRTAPNECRGTCVVDDHLALELTRGRGEPPVHGVAEGLDAEPAEELARAIAPMRDRLSLGGTAASLPTQVRLLDLVGIQRPSAGAVAELWAASPGPTTRVVLGADADGPVTIDLAAQGPHTMLGGATGAGKSILLQTLVTSLLLANAPDELNLVLIDFKGGGAFLPFENCPHVVALLRSTGETAADVFDQAAARRVLASVRAEVHRRERLLARYGGEIDEYWRARRTGRPMASLPRLALVFDEFARVLETSPDFLRELVNVAAKGRSLGMHLVLATQSLQGKLSAELKNNIDLRITLRQNEPADSIEVLGVPDAAAIPGRLRGRGLILFTKDETRAPRPFQSGYLGDPPPADGAPPARVRVVDWGALGLPRPEEKVDHGGAATDQTLTIRAIEEAAARADLPAPFRPLLPPLPADLTIADLAAAATTPAGATEIPVGLADEPAVQAQPPLVFDLAGTDRLLAAGGPQSGRTTLAAALITGMAARFRPDEAHVYVIERQPAGLDAYTALPHCGAVVSTAEPDRVRRLTAWLLGEVTTRLSTRAAPAGLGGAGARGGASGGGGGAAAGPGGGARWPWIVLIVDGWEYFENRADPNFVETTPLQELREVIAAGPPVGVHVILLGGHDLAGSRTAALFTRRLLLPFGKEELRRLHYPTGTPSPPDLPGRAVDAATGTHLQLVRSHLSAARLTEYVTQLRLGPAIDDARGPDRRSEPDRAGPARQVRMASHSESGPAANADSDRSPADLASATHRRAFVPPTAVAPLAFGLPRAFPSMPIRVRSDELPAPHPAPSPTWLPLGIGGKDVATVGLDLFGPGPHALLVSGPPGSGRTTAAATIVRGLRRLGVGTLVVAPPRSPLPALLGDDDPGIRLIRAGDVKDTQLREAAETFGDGRFAVIVDDCDHLTIEPTVVNFADARTLLEDAASPAAAGRQALILCGDATPILNGQRRSLLKVTNEIRTSGGLLLLTPTSPHTAREHNLRLEPDQLVPTPPGRGYLTIRGTATLIQLAT
>NC_014666.1|WP_013422531.1|1677016_1677808_+|DUF4389-domain-containing-protein
MPTEPYPDSPAPSAPLPADPGHPVRLDAEPEPDERLSRWLWLVKWFLIIPHSIILLFLWIAFFLLTVVAFFAILFTGRYPRGIFRFNVGVLRWTWRVRYYAYGALGTDQYPPFTLGDVPDYPIRFDVAYPERLSRGLVLVKWWLLAIPQYLVVAIFAGFGDWGGGGHRFLHGDHGFGGPPGLVGLLIAVAAVVLLFRGRYPRPLYDLIIGLDRWTARVIAYAALMTDVYPPFRLDQGGPDPSAAPTPPAPPAPTWPAASVDAS
>NC_014666.1|WP_013422530.1|1674626_1676753_+|potassium-transporter-TrkA
MAKVSGHVIVCGLSALGSRVAEQLVASGVAVVVVDDRDPTGSRRRLERSGVRVVPESAHSPEALREADIDTALAVAACGDLDLDNLQTAIAAAEVAPSRRLVVSIDNAQLGDQLATAIPAATVINMADRVGPSFVEACIRSDVVHAFTLFADPATNHDQEASEVFAVVDAVVDEADAFRARYGDLTPIALRRPSDRDPVLCPPRDIPLAPGDQLTMLGRLAEFDARGLTVAGMHDARTFAEIAAVARKRQERSGSDPILRSDAGQGRLGRVRALLATIRAEFDGPFRWALAAVLTLVVLSTVVLRLTYAANDPDAPDNFDAFDALYLTVETMTTVGYGDFNFGDATHWLQAFGILLMLFGALSVAVIYAFITNVIISRKLEKALGRGRAGTVRGHVVLCGLGKVGTATMEGLLRAGRAVVVIERDEHNRFLPVARERGVPVVIGDATVRTTLLQAGLGHATAIAALTSDGVANLETVLSARDAYEELAQARDERLAARHAASKAGGRSYQRHARVAAGPTPDAGSDETALRVVLRVADASMTSEVERRFDIHTVRSAAALAAPYFVGAALGYDVISTFYVERTPFLVARMVVRPGAALVGPTLAELATGARILAVTAAAEPHRAGPNGETPAAAVNGAAVNGAAPARPNLRPSRHTRLRAGDELLAVGPVTEIVDMIRRNQRPVDARRSESLSPAGANGTAEPEERDG
>NC_014666.1|WP_013422529.1|1673548_1674364_-|siderophore-interacting-protein
MTTPSVRGAAGRRGHRPPPRQVEVVGVERLTPRLTAVHFSGAGLVGFPTPAPTAHIKVFLPDENGTLALPQLGPDGLVMPAGKRPTMRTYTPRRYDAATNTLEVQFVLHGEGPASTWAQRAAVGDQVAIAGPGGRFSLDETVPHWWIGADESAVPAVATLLEALPDTATAEVHLEVAGAQDELPLPARAGTTITWHHRRVADAWGAELATAARSATPPAGTQVWVACESGAVRQLRSYFLTERQWPRAALTSRGYWRLGAADHPDHDYGED
>NC_014666.1|WP_157735322.1|1672322_1673306_-|hypothetical-protein
MRRRRARPRTLCLIAGVGALTLAMTGCMGGGGAPTSAPSVSPSPTVRRSLPPPTAMSREEFQQALSTVDAALKPGFDAIGAAQTPTDLANALGAVQLNLDAQAGVLGNLRPPRPEVASTGQVITAMRDLSNDLATIATDTKDASVCTGGTGLPRASNVNGAQEFRLAYLALTTADPGHPYTFGTFLPAATADPDRRPGTGPLPGGRSSGYGHLTVENQGAADSVVKVMSGGDLIRAVYVQAGGSATVTGIPNGTYDAYYTTGTDWDDGNRRFTRDCAFDKFDNPVEYTTSSTSTTIEYSVWTLTLHTSDLTNSAPTSPIDAGAFPAS
>NC_014666.1|WP_013422527.1|1671635_1672259_-|TetR/AcrR-family-transcriptional-regulator
MIRLMTRAVIVTDPAARNAVLSSAAECFVRLGVSRTTAADIARGAGISRATLYRRYGGTVEIFHAVLARESEQMSADAAELLASVTDPSLRLVEGMVFAIREVQRRPVHAALFSTGDAAWSARRAIRATSLRRISEDAIRPLVDVTVAGLAEPELGDLVDWILRLIISYAAVPGPGDLDEATIRRQLNRLLVPAVTALLGLATPEEI
>NC_014666.1|WP_013422526.1|1670565_1671600_-|zinc-binding-dehydrogenase
MKALQVREHGDPTDVLAVATVELPVPGPGEVRVRVGAGSLNFNDIDRCRGNLVSLPTPPPFTLGMDVCGVVDAAGDGAEAWVGRRVVAITKNALGGLAEYAIAPAVSVFEAPPGLDDAEATAFLLPFHTGALALLHRAQLTPAETLLIHAGASGLGTAAIQLGQAIGARVFVTVSSPAKAEVCERLGAEVVIDHTKDDFAEAVLKNTDDVGADVIYDLSGGAFVGKSWTCIARDGRYVPVGFADDPENGMTGRPLRLACIGNFSIVGVMLAWVDQIDPGMRRFGLNPFGRETADEVHGQLLDLLAAGSIRPFVGRRVTIEEAPAALGDHQARRSVGRTVVELGA
>NC_014666.1|WP_013422525.1|1669141_1670560_-|sulfotransferase
MATEPTNAVAPTTPAVPGVSPAVEAETAQAAGAAADPGPLANPAGDPRQAAPVREYTWREAELRNPPLRLLNAVGAGLRRLRLDWPALSPEKVVAAAQARARAQFGADDLGSASYREPLERYLAAAATEADLTTFGRLLVTRMLANALVNRIALQAWTSAHPEIRAEQIESPWIIVGLPRTGTSLLSILLGLDPLSRPLRQWEAAHPIPPPTLETAAEDPRIAQSARELGQLLRLNPALGAMHPFGASVAEECIALFMYDLRTLGIETQAHVPSYGRWLETTDMTPAYAQHKLALQAFQSAQPTGHWVLKSPNHLWCLPTLLAAYPDARVIWTHRDPAPVVTSLASLNNAAQRPLTKRTDPRPTAEEWKGKARRAISAAMAFDTDSPPGWCVHVRYDQLMADPVGAVGSLYERFGLTVRDLHARRMRAWLAQVPQDAHGRHRYTPTDFGWTYPRLTDEFADYTTRYAVPTET
>NC_014666.1|WP_013422524.1|1668754_1669075_+|N-acetyltransferase
MPGKRTLTDATARHRFELDIDGVLAGFVTYTAHAGIIAFNHTETLPAFAGQGVGGDLARGVLDEARARQLKVWPRCPFISAWIGKHPDYEDLVDPEWSAEHEPADG
>NC_014666.1|WP_013422535.1|1688383_1688680_-|WXG100-family-type-VII-secretion-target
MANIQVDYEAIRSTSTALSRAQTDMEGQLTTLKGLIDNLVTSGFITDQASGRFHEAYVSWDTGTRQAMTGLTGMSRFLTDAISQHEQLDVTLGQAAGG
>NC_014666.1|WP_157735323.1|1688821_1689454_-|hypothetical-protein
MVAGQRGFSLRVPDSWFAFDVRRATRTGDLARLVDARTAAEPRLRPYRSALLKMLREVADRAERRGAVYCAAAPADDPGGGTVATLLVFESAGADDPADSTVAAIAGALTARAPAQPGGPWRTVETVRIPAGEAVRIRAVEPARLDGGTAVDTVTMQTLIPVPATDHEEWQVGVLNVVLTSPHVGLADPLLDLFEAISDTLQWSSSNPPG
>NC_014666.1|WP_157734837.1|1689459_1689963_-|hypothetical-protein
MFAGLHRINRRSIASTGTAPRQPVPGFRPRRGCTVVCQVRGGWSVMAGIFGLNSAAAVALSGELAAIRASLASLGSDIDEARGITGSTEVEDALERFVRDSSDSRGNLDQLLARAIGLVNGLVDGTVAVDTGLAQALGPASGPASSTPAATGGLGGALGLAAAAGAP
>NC_014666.1|WP_013422538.1|1690358_1691111_-|ATPase
MPNEPTSDKPIPGGREFAIERETELRTTPEDYWEAVTNGNAAWLWPMEAPEPRVGGAAAFGGTVLAWEPPHHLIMRSEGPEGWFNQLEHLIEARDGGTTWVRYVHSGVFVDDWDNQYDGAGKHTDFYLHTLGQYLRHYNGRPAKYVSVDAPASSVTPDGFDALRRAAGLADAKVGDRVQLTIPGLPALDAAVDYLTPHFLGLHTEDAMYRVFGRNAFGAPVAVAVHLFSPDADEPTVDKALHAWLHGVYA
>NC_014666.1|WP_013422539.1|1691112_1691760_-|helix-turn-helix-transcriptional-regulator
MLDVAVIDSPGAAEASLDPVRARLLAALAEPGSATSLAARTGLTRQKVNYHLHALEQHGLVELVEERRKGNCTERILQATASSYVISPAALADVAPDPDRARDEGSARWMLALAARLIHEVGQLLAGATAARKRLATFAIDSEIRFATAADRAAFAGELSDAVTALVARYHDETATGGRPHRLVIALHPSLKPPDAGTNQQRRPSPPEPGLTEES
>NC_014666.1|WP_157734838.1|1691905_1693816_+|DNA-polymerase-I
MVSSWAADDPAGPARPASLASPAGPALPASPASPASALRASGVGPGTAVAVVAVPGVGVALAFGDGGWAGHADPAAVLTDVEAAIGPRWVWWSARGAGSPLAGGWRQSADRGPALSWDLAAVHRILRGGHRDDPGAVWAATRGLPVPPLPRRARGDGQLDLLAMVEQQDDVGDVDDPVGLDGQLRLGWVDETLGATAAGGPGVRLARAARFARLALVAMAAQEQALSTLPDPRASPGRLPLALLTARAESAAEVLARELERDGLPVDRPTATATITEIIGPPPVGDAGEAAARRTRDAPVLRQLSSSVDLRNPASVRAALAAVGIDVPDTRSGRLRALSAAHPVIDELLAWRKAERIATTYGHRWLATHVGADGRLRGRWHGSDGAAGRMTADAGLHNLPAEMRVAVVAEPGHRFVRADLGQIEPRVLAVVSGDPELTRATRQDDLYAPVAARLGVDRPTAKVAVLAAMYGQTTGAAGQALRQMRETYGVALAYLDAADAAGRSAALGAAPATPLRTFGGRRIPLRALPADADGDIGRAAAAYGRFARNAVVQGAAAELFKAWAVTVRQALIPLGGTIVLCLHDELLLQVPVQTAEAAVAATHRALDATAAHWAAGSAVRFVADIAVISRWSDAKP
>NC_014666.1|WP_013422541.1|1693918_1694362_-|oxidoreductase
MRSVYEEAGGDEGLRRLADAWHRRVMADEVVSHAFSHGFRPDHLERLASYWAEALGGPTSYSDQYGDETLVVRLHSGNGPHDDMDRRAIDCFDEALADAGLTAEPLRQLLHDYFAWATTTTMNRYHDSADDVPAGLTIPRWSWAGLV
>NC_014666.1|WP_013422542.1|1694385_1694793_-|nuclear-transport-factor-2-family-protein
MIEDKVVTALQRHWEDGFNQYDLDLVMEPVDRDVVFSSPFVPRLTGDPEKVTIEGYDAFRSYIDDSMRRVPDIRYSIDASFVSTQTVVFVYTCRFTDGQVKTGADSIRLNRDGKIVEWRCHYSFDPEALDSLIQD
>NC_014666.1|WP_013422543.1|1695201_1696068_+|ATP-binding-cassette-domain-containing-protein
MPEPAPEVLRADRVDLVRGGRYLLRGVDLTVRAGEHWTLLGPNGAGKSTLLGLLGAVSHPTSGTVRVLDHQLGKVDVRALRAFIGHVNPRHPLLTPLTIREVVLTGATSTIDLVPRWTPTAEQERDADELLDLLGIEALRSARWPELSQGERGRALIARALMPRPRLLLLDEPTTGLDVAAREQLLSGLDDLRAEQPGLASVLVTHHLEEIPASSTHALLLREGETVAAGPIDEVLTTDLVTACFAHPIRVARLEGRFVARAQRTRSLTRGRLGPEAARDPEPTGARG
>NC_014666.1|WP_013422544.1|1696109_1697123_-|LuxR-family-transcriptional-regulator
MTNLDFLGLTPFGQQVYEQVALHPYADTEGIAGFLGADVAAVAAELRDQANRGQIRSVGGAWLAEDLTQWLDTEHARQQAEQATAAAERARQRSRLLRSRLPAAHRQGTRKLVGNDGTELVTHGEVSIRIAELAEQATDTLRFMLAGNEGFGPNPHVIRAFVGAAKRGVRLTSVWTPECIAAARGAPNGRLPPLGQVHASRDVPYRAVVADGRAVLVQREPDDPSLGALVITHHPTVALYAHLIDALFRAGQPLSPNVPPPAADTLDPQRESQILHLIATGATNDLIGKNLGVSTRTVQREVSRLMERYQARNRIELITLTTDLPADQVGDAVGHES

Crispr_ID: NC_014666_4

• CRISPR_ID: NC_014666_4
• CRISPR_location: 1854578-1854911
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 4 spacers

Consensus repeat of NC_014666_4

Consensus_repeat	Method
CGGCCGA---TCGTAACG------------------AGACGACCGA--AACGAGC	PILER-CR
CGGCCGATCGTAACGAGACAACCGA	CRISPRCasFinder

spacers of NC_014666_4

>4.1|1854610|49|NC_014666|PILER-CR
AGCTCAGGCCATAGCGCGAGCCGTCCGCGGCGTGCGCCGGCCGCTGCTC
>4.2|1854691|49|NC_014666|PILER-CR
GGTCCGGCCCACAGTGCGAGCCGGGCCGAGCCGGGCCCAGTCGCTCTGG
>4.3|1854772|46|NC_014666|PILER-CR
GCGGCCCCGCGCGCGAGTCGCCGTGCGCGTGCCCTGATCACTCCAC
>4.4|1854603|56|NC_014666|CRISPRCasFinder
AACGAGCAGCTCAGGCCATAGCGCGAGCCGTCCGCGGCGTGCGCCGGCCGCTGCTC
>4.5|1854684|56|NC_014666|CRISPRCasFinder
GCCGGGCGGTCCGGCCCACAGTGCGAGCCGGGCCGAGCCGGGCCCAGTCGCTCTGG
>4.6|1854765|50|NC_014666|CRISPRCasFinder
CACGGCGGCCCCGCGCGCGAGTCGCCGTGCGCGTGCCCTGATCACTCCAC
>4.7|1854840|47|NC_014666|CRISPRCasFinder
AACGAGCGCCCCGGCTAAGGGCGTGAACCGTCCCGAACCCGTGCCAG

CRISPR arrays and Neighbor proteins around NC_014666_4

CRISPR arrays

The CRISPR arrays of NC_014666_4

>merge|NC_014666|4|1854578-1854911|PILER-CR,CRISPRCasFinder
CGTCCGATCGTAACGAGACGATCGAAACGAGCAGCTCAGGCCATAGCGCGAGCCGTCCGCGGCGTGCGCCGGCCGCTGCTCCGGCCGATCGTAACGAGACGACTGAGCCGGGCGGTCCGGCCCACAGTGCGAGCCGGGCCGAGCCGGGCCCAGTCGCTCTGGCGGCCGATCGTAACGAGACAACCGACACGGCGGCCCCGCGCGCGAGTCGCCGTGCGCGTGCCCTGATCACTCCACCGGCCGATCGTAACGAGACGACCGAAACGAGCGCCCCGGCTAAGGGCGTGAACCGTCCCGAACCCGTGCCAGCGTCCGATCGTCACGGGACAAACGA

>NC_014666|4|1|1854578-1854846|PILER-CR
CGTCCGATCGTAACGAGACGATCGAAACGAGC	AGCTCAGGCCATAGCGCGAGCCGTCCGCGGCGTGCGCCGGCCGCTGCTC
CGGCCGATCGTAACGAGACGACTGAGCCGGGC	GGTCCGGCCCACAGTGCGAGCCGGGCCGAGCCGGGCCCAGTCGCTCTGG
CGGCCGATCGTAACGAGACAACCGACACGGCG	GCCCCGCGCGCGAGTCGCCGTGCGCGTGCCCTGATCACTCCACCGG
CCGATCGTAACGAGACGACCGAAACGAGC

>NC_014666|4|4|1854578-1854911|CRISPRCasFinder
CGTCCGATCGTAACGAGACGATCGA	AACGAGCAGCTCAGGCCATAGCGCGAGCCGTCCGCGGCGTGCGCCGGCCGCTGCTC
CGGCCGATCGTAACGAGACGACTGA	GCCGGGCGGTCCGGCCCACAGTGCGAGCCGGGCCGAGCCGGGCCCAGTCGCTCTGG
CGGCCGATCGTAACGAGACAACCGA	CACGGCGGCCCCGCGCGCGAGTCGCCGTGCGCGTGCCCTGATCACTCCAC
CGGCCGATCGTAACGAGACGACCGA	AACGAGCGCCCCGGCTAAGGGCGTGAACCGTCCCGAACCCGTGCCAG
CGTCCGATCGTCACGGGACAAACGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_014666.1|WP_071587930.1|1847513_1849253_+|TIR-domain-containing-protein	unknown	unknown	gnl|CDD|238121
NC_014666.1|WP_013422668.1|1844881_1846381_+|hypothetical-protein	unknown	unknown	gnl|CDD|237537
NC_014666.1|WP_157734852.1|1857661_1859002_-|hypothetical-protein	unknown	unknown	unknown
NC_014666.1|WP_013422683.1|1862500_1863361_+|hypothetical-protein	unknown	unknown	unknown
NC_014666.1|WP_013422672.1|1852093_1852294_-|hypothetical-protein	unknown	unknown	unknown
NC_014666.1|WP_013422671.1|1849867_1852006_-|cell-division-protein-FtsK	unknown	unknown	unknown
NC_014666.1|WP_013421767.1|1861074_1862271_-|IS110-family-transposase	unknown	unknown	gnl|CDD|376564
NC_014666.1|WP_013422685.1|1864674_1865385_-|methyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|372616
NC_014666.1|WP_013422666.1|1843417_1843735_+|4a-hydroxytetrahydrobiopterin-dehydratase	unknown	unknown	gnl|CDD|376528
NC_014666.1|WP_013422665.1|1841911_1843405_+|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|378971
NC_014666.1|WP_157734853.1|1860565_1861069_+|hypothetical-protein	unknown	unknown	unknown
NC_014666.1|WP_013422686.1|1865594_1866806_-|cytochrome-P450	unknown	unknown	gnl|CDD|225035
NC_014666.1|WP_013422664.1|1840448_1841699_-|methyltransferase,-FxLD-system	unknown	unknown	gnl|CDD|275158
NC_014666.1|WP_013422679.1|1856727_1857237_+|hypothetical-protein	unknown	unknown	gnl|CDD|274852
NC_014666.1|WP_013422675.1|1852935_1853133_-|hypothetical-protein	unknown	unknown	unknown
NC_014666.1|WP_013422684.1|1863378_1864293_-|tyrosine-type-recombinase/integrase	unknown	unknown	gnl|CDD|234698
NC_014666.1|WP_013422676.1|1853762_1854149_+|hypothetical-protein	unknown	unknown	unknown
NC_014666.1|WP_013422667.1|1843955_1844885_+|hypothetical-protein	unknown	unknown	gnl|CDD|237537
NC_014666.1|WP_013422678.1|1855411_1856545_-|transcriptional-regulator	unknown	unknown	gnl|CDD|376540
NC_014666.1|WP_013422682.1|1858998_1859880_-|phosphotransferase	unknown	unknown	gnl|CDD|366736

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_014666.1|WP_071587930.1|1847513_1849253_+|TIR-domain-containing-protein	gnl|CDD|238121	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.	5.61869e-68
NC_014666.1|WP_013422668.1|1844881_1846381_+|hypothetical-protein	gnl|CDD|237537	PRK13875, PRK13875, conjugal transfer protein TrbL; Provisional.	0.000125886
NC_014666.1|WP_013422685.1|1864674_1865385_-|methyltransferase-domain-containing-protein	gnl|CDD|372616	pfam13489, Methyltransf_23, Methyltransferase domain. This family appears to be a methyltransferase domain.	5.81939e-07
NC_014666.1|WP_013421767.1|1861074_1862271_-|IS110-family-transposase	gnl|CDD|376564	pfam01548, DEDD_Tnp_IS110, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family includes an amino-terminal region of the pilin gene inverting protein (PIVML) and of members of the IS111A/IS1328/IS1533 family of transposases. The C-terminus is represented by family pfam02371.	1.08142e-57
NC_014666.1|WP_013422684.1|1863378_1864293_-|tyrosine-type-recombinase/integrase	gnl|CDD|234698	PRK00236, xerC, site-specific tyrosine recombinase XerC; Reviewed.	7.39322e-43
NC_014666.1|WP_013422666.1|1843417_1843735_+|4a-hydroxytetrahydrobiopterin-dehydratase	gnl|CDD|376528	pfam01329, Pterin_4a, Pterin 4 alpha carbinolamine dehydratase. Pterin 4 alpha carbinolamine dehydratase is also known as DCoH (dimerization cofactor of hepatocyte nuclear factor 1-alpha).	8.51052e-22
NC_014666.1|WP_013422665.1|1841911_1843405_+|helix-turn-helix-transcriptional-regulator	gnl|CDD|378971	pfam12844, HTH_19, Helix-turn-helix domain. Members of this family contains a DNA-binding helix-turn-helix domain. This family contains many example antitoxins from bacterial toxin-antitoxin systems. These antitoxins are likely to be DNA-binding domains.	0.000178763
NC_014666.1|WP_013422686.1|1865594_1866806_-|cytochrome-P450	gnl|CDD|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	4.27881e-94
NC_014666.1|WP_013422664.1|1840448_1841699_-|methyltransferase,-FxLD-system	gnl|CDD|275158	TIGR04364, methyltran_FxLD, methyltransferase, FxLD system. Members of this family resemble occur regularly in the vicinity of lantibiotic biosynthesis enzymes and their probable target, the FxLD family of putative ribosomal natural product precursor (TIGR04363). Members resemble protein-L-isoaspartate O-methyltransferase (TIGR00080) and a predicted methyltranserase, TIGR04188, of another putative peptide modification system.	0
NC_014666.1|WP_013422679.1|1856727_1857237_+|hypothetical-protein	gnl|CDD|274852	TIGR03917, hypothetical_protein, Frankia-40 domain. This model describes a paralogous domain of length 40, restricted to smaller proteins of the genus Frankia, a member of the Actinobacteria. The function is unknown.	9.85363e-10
NC_014666.1|WP_013422667.1|1843955_1844885_+|hypothetical-protein	gnl|CDD|237537	PRK13875, PRK13875, conjugal transfer protein TrbL; Provisional.	4.95804e-05
NC_014666.1|WP_013422678.1|1855411_1856545_-|transcriptional-regulator	gnl|CDD|376540	pfam01381, HTH_3, Helix-turn-helix. This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within Neisseria gonorrhoeae NGO_0477, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteristic of the whole family.	2.1147e-10
NC_014666.1|WP_013422682.1|1858998_1859880_-|phosphotransferase	gnl|CDD|366736	pfam01636, APH, Phosphotransferase enzyme family. This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.	1.14969e-10

Protein sequences

>NC_014666.1|WP_013422676.1|1853762_1854149_+|hypothetical-protein
MHTHDRPDVETVETLLGKARRHGAGAAELARHRPDLVDLLTPPDGTSPKTRALLAERIIRAAIDRLDPPADSAMRALFGLTAETRRRSVAYRRDEAARLICLTPGAFRRPNREGSMILDIAFEIVTAE
>NC_014666.1|WP_013422675.1|1852935_1853133_-|hypothetical-protein
MPRFVYRPSLLSRLFRWSLAVSALYLALFGLSYVAGHLLSAVGPFLIVAGLAYGAVFLVHRGRDR
>NC_014666.1|WP_013422672.1|1852093_1852294_-|hypothetical-protein
MEITIVILLGALLLVALIAPRTRTRSLVPVVCILLGWYWAGSGFVPTIAAVLTQIHGFLRTLPIRY
>NC_014666.1|WP_013422671.1|1849867_1852006_-|cell-division-protein-FtsK
MTDNLPVPAEQSGWVPDIPAVLAEIRPMLPAATGTQERSYEWPIDQRPDGRLAPVDPSGDRPADIGRRPVIPEQLRSSRLGPTLRHTSGRWAHIGAFHAVRAPWYLIVVARASVLGACRLVARLVRWWACAESAPLRRAAVDSGDSAAWLRLDREARSTRRTRTGLTVVAGGAILAALTATLPALANAPWPATALTVALLVAVLARAGRPAGGPLIAPAIVTPRFRKLNADVVLRAYYAARLGADKDDQRVTFGSPMARDGDGSRVAVDLPYGRGFTDAVKAHGAIASGLDVAVTQVFLTRDPTSHRRHTLWVADRDPLAIPAGRTPLLRGRPTDIWTPAPFGLDERARPVTVDLMWNSILVGAQPRQGKTFALRSLGLFAALDPYVRITVADGGGKPDWRKFEAIADRAVFGLAPTRDGDPVEILIDTLREIRSDVQARYLALSDLPPDVVPEGKLTREISRDPKYGMPVRLLLLDEFQEWFATGNPAADSEIATLLVYLIRVAPAAGVIIGSATQRPSGIGSGDVAKKFTDYRDNHLVRFALRTGSWQVSDLVLGAGAFSEGLDSSTLTAEHKGAGILRGASDTNPTVRTYLADAEDAAHLLAIARKLREFTGTLSGQAAGQIAHREQRDVLADALSVFADGAPGLHWAELAIRLATAYPEHYRDATAEAISAQLRAFGVPSVDVRRDGQVRKGARADAIREAHRARADL
>NC_014666.1|WP_071587930.1|1847513_1849253_+|TIR-domain-containing-protein
MGDASAEPQAESWDFFVSYTTANKTWAVWVAWQLEDAGYRVLIQEWDFVPGSNWHARMQQGVLFSQRTIALLSNAYLNSVYGQQEWQAAQQADPQGFKRKLLPIRIEDCPRPGLLGLVVSIDLFGRDADDARRHLLDKVEHAIKGRAKPHAAPDFPQFAKAATPPNEPGFPADNTRPDMPIPDPQAPPFSGQSIRAVLDSRPTEAPYDQNSSEPPPSTGESRSSAADARPNRTLSDNPTWSVPAPPRRSNLNRGSRSLPDPRPAGAPLLGHTRGVRSVSFSPDGKILATGSSDTTVRFWDVTDSARSGESTTLLTDHTGGVSAGVFGSYAQIFATCGGDVRLWNMTNPAAPQLITALPRPSLGAVRTLAFSPDGRTLATGSVDAIVRLWDLRNPAQPSPIATLPTRHTGVVGALAFSPDGHALATASSDESVLIWDVDRPGRLFAELSGVNAAMWAIAYSPDGRTLVFGGERQSVIIWNVEDARRPRKIAARLGSHAEGVRSLVFSPDGSMLFTGSVNQTVRIWDVANPVRPSLIDDLVTAHTGIVNAMAFSPDGRKLATGSSDTTVQLWQTRPSEQGT
>NC_014666.1|WP_013422668.1|1844881_1846381_+|hypothetical-protein
MTSTEPDHTPSQAATGRFPGWLTGGADAAVLAVIDLATRRTAAEVVETLNGRDTVVRLAQRYANLGNPQRAGHLFEVMHTVGFNRHAARAGATVRAQVLEWTQGGSQNGPADIRLVDGGRTIAEIQAKLVGRVPGAAREISRPSYRGMGRLVAADRLDDVNNLLDRRLTMHPQGVFFDDYLDARARTSSQLAHESVRGDPIGYQQAQVAASDPIGWANHQVASAVARDVVAASAAAAAAGAVVGALVSAVGETARVRAGETSAGAAIITAAGAAARGAARSGTVGAISASVRTAAATGVLPTALGGGTVPAAMADAVWVVADAGLQLAKGHIDPGEFAARGAAGTIRAGMVWAGGLVGQTVLPVPVLGALVGGVVAQATAALVLQGLQLAIVAARADGTDHDHLALLEAETVTTAATAALIGRATKALGEDQHTQLALAALPALAHIQATLASPDPGKAITELATVTCRHASQPTFTTADEFDLWMINDNTGLVLNPNW
>NC_014666.1|WP_013422667.1|1843955_1844885_+|hypothetical-protein
MGIAIVDAVKLAKDNKRSYEHLDARRQSLAQKMAAESGAQQKSRTELYESALAPFQKVFGRLKNVDLVELARIDLMTGRNLPEAALPGIRIGVVQSLGVLAGGAAAGAGVGAATFAAVGAFATASTGAAISGLSGAAATSATLAWLGGGSIAAGGGGVAAGTTVLSGIVAAPVALALVAIVEWQGRKARNGERVTSAKLVEAAAALDRAEADSALVRRRSRQVRDVLGDLRVALSDRLPSLDALITSNPDYMTYTSEQRRVVAQPVAIASAAVMVMSTPIATDDGTVNEHIRPAVLAAKQRLLLMTEPS
>NC_014666.1|WP_013422666.1|1843417_1843735_+|4a-hydroxytetrahydrobiopterin-dehydratase
MGLRDPLPADEVTRRLAQLEGWEKAPDREEIHKTFRLDYYASVKALNDVMTPAQELQHHPDIDLRWETLHFSLTTYTAGQKITELDFLLVDRIEQVLAGYITAAE
>NC_014666.1|WP_013422665.1|1841911_1843405_+|helix-turn-helix-transcriptional-regulator
MTSDRPRRHCSRCGHRLAADNRAATCSACQSTATSDRGHPPDVPNEFWRAVAIGEAIATWHMGRVIYAYRCHPWHGQALPQELVAGWLGLTQAQLSRIENGRAPEELSKLVRYSQILGIPADLLWFDRPGDPRQRQPADPPRSRESDVELLGVAAADGGGGPYRVLAEVGEVIIVAVDRRTFLAGSGAGLLVGGQAVPVESPGQVAGQVVDHLTGQIESFYAAEAVYGPRAVIPSVLVQQELTRQLVGASRGAIRQDLLRTSAAYTGRLTWLRQDAGDFATASQWANETLELSHRVGDAQLIRHALVNKAMICTDQRDGAGTLDLTDAALADEAVLCAKVRVQALQQSAHGHALLGDRTATDTALDQASALLARVDDDYPWYNACRRTPNYLEAQRATCYNRLGLGTEARTLWEQVIGALPPGARRDAGVYQTRLALSYAQAEQPDEAVGAIDDAVTIARETGSARLRQELHDVWHQLTPWHDAQPGREAKDLLATL
>NC_014666.1|WP_013422664.1|1840448_1841699_-|methyltransferase,-FxLD-system
MSNARVEPGPADDDRAGARRAAMVQRLRELGAVRGEDVARAFSTVPRHLFAPGASLEAAYAPENTVLVRRDDTGALVSTVSAPHIQAMMLEQVQVRPGMRVLEVGSGGYNAALLAELVGPSGAVTTVDIDPEVVDRARSCLAAAGYDQVTVVLADADAGVPDRAPFDLVLVTTGMWDIPPAFTDQLAPGGRLVIPLRLRGLTRSVVFESAGGRLVSRGYELCSFVPVRGVGAHPDEVIRLDGDDAAIRFEDPPDADPVLVRQAVSWPRVEVWSSASVGEDGSFEGLLLWLATGLDNFGLLMARPAAVARGVVGHAWPLGIPTIVGKGSFAYLALSPKAPGQTSREFGVYAHGPDAEALAERMAARIRTWDGGSLTARIEAFPADAPDLVLPAGAVVLDRRHRRLAVSWPTATDLPN
>NC_014666.1|WP_013422678.1|1855411_1856545_-|transcriptional-regulator
MEKRPGLAARRKAVGLSQEGLAEALETARSTVARWERGEVAPQPATRAPLAEILQISLDDLDHLLNGDEPEKVHDPVQVGPTEPVGPLHTERARDRVKQLLAMERTFGGTRIADLAVDSARAFERRITDAGVRPGYKSEAHAVAAELFEISGWLLVDAARPTDVDHANSRALHHAAVAGDHGMEIFVLQNESMHLCETGRATEALYLARGVLDQPLSPRLSAMFHVREARALAARGDHESRRVWQRAVAEFGDGVRDSDPYWVWWLDDEQMELQKALLLKDLDEHELAIRAFREYLETRPDSLYCSLTLPNLALSQVLAGAWRDAEGTVRDIVDAADDSHSGRLNVRIVRLADTVKRSPAAPRSLRDAAHALAVFAG
>NC_014666.1|WP_013422679.1|1856727_1857237_+|hypothetical-protein
MTVVEGVSGLVIGRGGAAAIGRWLRRSRRGRHQLGPRTMALVDRGDGPRATWVRLYRAASPHDPNDAAAVQAGDASGPEPEAPGFGPSESQPCRVKAAVGGPAVTVTIWPGQRPDDLIDQLARVSDGMEFVEVFGDRSLVLVYGPTGVPPTRRSMLRAVVASLGPDDDG
>NC_014666.1|WP_157734852.1|1857661_1859002_-|hypothetical-protein
MSAAASAGSARPFDPIVARPSHRLSIVIATSAETADLLRADGQLPETYLRLGRLAAFYRDADSQLPRVLAVRDLDPPTLAFRRGGGTAATIRAARLWLFDVQAGPIVAVLSVDLDCEPLVLIPFLEDLYYDDLTIGGSPIDGVAADLLDGVDAAVRHSAGSRLELTSQRHQMVFTSATLPEDSVQRLIYRADLDANPQYSSIQYPAELNRRPTSGAAVGAYVSVLAAQQDYIENCALLSSVQVVAASCKIRRVRFAAYETLLRVRELGTTRATMSRPERRAELARLHETLAEQELALTFGVEAACEIGILVPALRVENFHRQLVACTGLRDSIETVSTMLARATSVLAAEEGSQTALDAQRQDLRRLRYGVTIGLLSTIAVPIGIILGFFGGNYTQVDGNRSMFDWSHYHDMYLAVLGLILAAGTVFAILFLLERLQIRRASKPSH
>NC_014666.1|WP_013422682.1|1858998_1859880_-|phosphotransferase
MAAFDVLARLGVDPPDLELLRFGENALYAFRERRLVVRVARPSTDPTHVAQTVEFVRRVAARGMPVSEPADLTELVQPVVTSTGVVTLWTLHDVDEGCRVSAAELGGLVRQFHELAAPEADLLDEWEPFGLIRSRLAAAERDGFDRSLTGPLVDLLASLETAVDRLSARLGIGVMHGDMHYGNVLCLPGRRLLLIDFDQVCRGPREWDLVPNLVTVRRFGLAESDYQEFCAAYGFDLRTSPDVETLVRLRELGMVSWLLQQYGTSAVIDDEIRLRVGTIGESVGPPATRWWAH
>NC_014666.1|WP_157734853.1|1860565_1861069_+|hypothetical-protein
MTITSGTFQKSSRALSRILSLSKLEDRVEIHAHRDIVIPVFESRIHRFDWELHGPAGGWITTDSKPNTLTALNPTHDVRLGWEVCADRTYPALPREDARRLHLEVAAHAALENDILIAEDPKLLADRYEVADLGAAGVFSPSEAVRILELWIRDRGESFMILNEVVK
>NC_014666.1|WP_013421767.1|1861074_1862271_-|IS110-family-transposase
MERVWAGVDIGKEHHHVVVIDADGARMLSRRVANDEPTLLDLLGQVTALAERVHWAVDLSTGGAALLLGLLVAHGQQVFYLSGNQVSRAAGGYRGEGKTDAKDAAIIADQVRMRRDLAPMRVDDELIVELRMLVARRRDLAGDRVRLVNRLHEHLLGISPALERVLNLTNRGPLVLLTHVQTPAAIRQLGPAGLEQWLRSQKVRGAAALAATVTAAANSQRTTLPGEQLAAQLVADMAKGVMSLDEQIAQTDTLIEGRFHRHRHAAALLSMPGIGVLLGAEFLAATGGDMAAFTSADHLAGYAGLAPAPRDSGRISGNLHRPRRYHRGLQRVFYTSALVSIRYNDQSRTFYDRKRSEGKRHTQAVLALARRRVNVIWALLRDNRCYQPAPPPLIAAAA
>NC_014666.1|WP_013422683.1|1862500_1863361_+|hypothetical-protein
MLEEHYSERLKGGLFIDAVVHGLAPNTLTAYRSSLEPARSATYQATVDFLHSNIDRMANLLIAVDELERISQVEGYMGGNNNLLARYGYHAQYALSLMAGLLDVVPWIFASSVGATPSPSRVSWNNLRSVDKPPPWIRDATGPIASLRDLARSGAGMEHGDFIYSLRAYVHHRHSLRGRVVEFWETSQPSARAKICAFDITEIDIPAGCGRSDGIYISDGQRLLIPAPFFASAARRVISIVDQLIGVGAWPNADWWRVSQDWARQAERIERHAEAARWLYDPNPDV
>NC_014666.1|WP_013422684.1|1863378_1864293_-|tyrosine-type-recombinase/integrase
MKATDASAVDDLTTLLPDWRRHLRALNRSPATIQSYLTVGESFVGYLTEQGMPRSAGAIAREHVEAYLVSLSERVSAATVAKHYRSLQQLFRWLVEDGEISRTPFERMSAPAVPEQPVPILGDDVLRKLLDACKGNSFENRRDAAIIRLFLDTGVRIGELVGLSVDDLDFDHDVAHVMGKGRRGRAVPYGNRTADALRRYIRARARHGQAKSPALWLGKKGPMTSSGISQMLERRAADAGVPKLHAHQFRHTFAHAWLAAGHQEQDLMRLAGWRSREMVGRYAASAADDRARDAHRRAALGDRL
>NC_014666.1|WP_013422685.1|1864674_1865385_-|methyltransferase-domain-containing-protein
MPPRLLDEDALTASSVVANRAMNRERQLAGVNSYERELGFNPLDWLRARAGSERHAGQTQITWLDLCCGTGQALLQAGDLLRAEGLGLAVRLVGVDLVDAFAPRTPGSDVELTTTSIVTWNWPGPFDLITCVHGLHYIGDKLAVITRAIDALTETGLFIADFDAVSVRRSNGQAAGRALTTALRTSGISYDARRHRLTCQGRREISPPFTYLGADDRAGPNYTGQAAVHSFYQVEY
>NC_014666.1|WP_013422686.1|1865594_1866806_-|cytochrome-P450
MSALPTVDVYDPVRYESGIPHDDFRVLRAQAPVFRHPDHERPDGLWAVTRHADVMRVSRSPELFSSSRCTAILAEMTEEQHTQQRLMMLNMDPPEHSRLRSLVNRGFTPKVVGRMAERLQDACDTIVDSALAVGTGDFIDLCAADLPLIVIAELMGVPIEDRHKLFDWSNRLASATDGRMDQNGDAAVAVLEAYAYANDLGAAKRACPADDIVSRLIAKDDQGEELSELEFDLFFLLLMFAGNETTRNAIAGGMQAMIDHPDQWERLRENPGLAPHAADEIVRWVSPVNGFRRTATRDVELGGQLIRENDKVVIFYASANFDESVFEDPYTFDIGRSPNPHLGFGGGGPHFCLGRHLAMLEVELMYRTLAARVRRVEPLRPPNRLRSNFVNGVTSMPVRLIPA

Crispr_ID: NC_014666_5

• CRISPR_ID: NC_014666_5
• CRISPR_location: 1888802-1888996
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NC_014666_5

Consensus_repeat	Method
CGACAACGTCCAGGTGAAGGACGGCAAGGTCTACCACAACGGAAAGCTGGT	PILER-CR

spacers of NC_014666_5

>5.1|1888853|30|NC_014666|PILER-CR
CGGCACGGCCAAGCCAGGCGAGCCCGTGGC
>5.2|1888934|41|NC_014666|PILER-CR
ACCGGCGCGGCCGCCGAGGCGCTGCCCAAGCCGCCCGGGGC

CRISPR arrays and Neighbor proteins around NC_014666_5

CRISPR arrays

The CRISPR arrays of NC_014666_5

>merge|NC_014666|5|1888802-1888996|PILER-CR
CGACAACGTCCAGGTGAAGGACGGCAAGGTCTACCTGAACGGGAAGCTGGTCGGCACGGCCAAGCCAGGCGAGCCCGTGGCGGTGAAGGACGGCAAGGTCTACACCGGCGCGGCCGCCGAGGCGCTGCCCAAGCCGCCCGGGGCCGACGACTTCCAGGTGAAGGACGGCAAGATCTACCACAACGGAAAGGTGGT

>NC_014666|5|2|1888802-1888996|PILER-CR
CGACAACGTCCAGGTGAAGGACGGCAAGGTCTACCTGAACGGGAAGCTGGT	CGGCACGGCCAAGCCAGGCGAGCCCGTGGC
GGTGAAGGACGGCAAGGTCTACACCGGCGCGGCCGCCGAGGCGCTGCCCAA	GCCGCCCGGGGCCGACGACTTCCAGGTGAAGGACGGCAAGA
TCTACCACAACGGAAAGGTGGT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_014666.1|WP_013422716.1|1900332_1900905_+|glyoxalase	unknown	unknown	gnl|CDD|319912
NC_014666.1|WP_013422698.1|1880819_1881641_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224048
NC_014666.1|WP_013422717.1|1900965_1901634_-|GntR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224715
NC_014666.1|WP_013422708.1|1892310_1893282_+|glutathione-synthase	unknown	unknown	gnl|CDD|235371
NC_014666.1|WP_013422712.1|1896101_1897295_-|DUF1214-domain-containing-protein	unknown	unknown	unknown
NC_014666.1|WP_013422701.1|1883586_1884930_+|amidohydrolase-family-protein	unknown	unknown	gnl|CDD|238624
NC_014666.1|WP_013422707.1|1889334_1892151_-|AAA-family-ATPase	unknown	unknown	gnl|CDD|226415
NC_014666.1|WP_013422711.1|1894901_1896038_-|Fic-family-protein	unknown	unknown	gnl|CDD|225718
NC_014666.1|WP_013422713.1|1897299_1898442_-|sulfotransferase	unknown	unknown	gnl|CDD|379204
NC_014666.1|WP_041259014.1|1884989_1885625_-|hypothetical-protein	unknown	unknown	gnl|CDD|99749
NC_014666.1|WP_013422709.1|1893278_1893677_+|MAPEG-family-protein	unknown	unknown	gnl|CDD|226311
NC_014666.1|WP_013422695.1|1877984_1879010_+|ABC-transporter-permease	unknown	unknown	gnl|CDD|223674
NC_014666.1|WP_013422697.1|1879923_1880823_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|223521
NC_014666.1|WP_157734855.1|1881684_1883091_+|hypothetical-protein	unknown	unknown	gnl|CDD|377179
NC_014666.1|WP_013422700.1|1883120_1883585_+|nucleoside-deaminase	unknown	unknown	gnl|CDD|238612
NC_014666.1|WP_013422714.1|1898446_1899364_-|NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|223528
NC_014666.1|WP_041259018.1|1887838_1888513_-|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|223816
NC_014666.1|WP_013422696.1|1879006_1879927_+|ABC-transporter-permease	unknown	unknown	gnl|CDD|224094
NC_014666.1|WP_013422704.1|1886411_1887839_-|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl|CDD|273593
NC_014666.1|WP_049807129.1|1899457_1900336_+|acyl-CoA-thioesterase-II	unknown	unknown	gnl|CDD|224857

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_014666.1|WP_013422716.1|1900332_1900905_+|glyoxalase	gnl|CDD|319912	cd07249, MMCE, Methylmalonyl-CoA epimerase (MMCE). MMCE, also called methylmalonyl-CoA racemase (EC 5.1.99.1) interconverts (2R)-methylmalonyl-CoA and (2S)-methylmalonyl-CoA. MMCE has been found in bacteria, archaea, and in animals. In eukaryotes, MMCE is an essential enzyme in a pathway that converts propionyl-CoA to succinyl-CoA, and is important in the breakdown of odd-chain length fatty acids, branched-chain amino acids, and other metabolites. In bacteria, MMCE participates in the reverse pathway for propionate fermentation, glyoxylate regeneration, and the biosynthesis of polyketide antibiotics. MMCE is closely related to glyoxalase I and type I extradiol dioxygenases.	6.30164e-10
NC_014666.1|WP_013422698.1|1880819_1881641_+|ABC-transporter-ATP-binding-protein	gnl|CDD|224048	COG1123, COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only].	1.85061e-103
NC_014666.1|WP_013422717.1|1900965_1901634_-|GntR-family-transcriptional-regulator	gnl|CDD|224715	COG1802, GntR, Transcriptional regulators [Transcription].	3.66589e-30
NC_014666.1|WP_013422708.1|1892310_1893282_+|glutathione-synthase	gnl|CDD|235371	PRK05246, PRK05246, glutathione synthetase; Provisional.	1.01957e-116
NC_014666.1|WP_013422701.1|1883586_1884930_+|amidohydrolase-family-protein	gnl|CDD|238624	cd01299, Met_dep_hydrolase_A, Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a conserved metal binding site, involving four histidines and one aspartic acid residue. In the common reaction mechanism, the metal ion (or ions) deprotonate a water molecule for a nucleophilic attack on the substrate. The function of this subgroup is unknown.	7.46951e-64
NC_014666.1|WP_013422707.1|1889334_1892151_-|AAA-family-ATPase	gnl|CDD|226415	COG3899, COG3899, Predicted ATPase [General function prediction only].	2.52182e-26
NC_014666.1|WP_013422711.1|1894901_1896038_-|Fic-family-protein	gnl|CDD|225718	COG3177, COG3177, Fic family protein [Function unknown].	6.62105e-26
NC_014666.1|WP_013422713.1|1897299_1898442_-|sulfotransferase	gnl|CDD|379204	pfam13469, Sulfotransfer_3, Sulfotransferase family.	3.46429e-31
NC_014666.1|WP_041259014.1|1884989_1885625_-|hypothetical-protein	gnl|CDD|99749	cd06260, DUF820, Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of nucleases.	3.30969e-22
NC_014666.1|WP_013422709.1|1893278_1893677_+|MAPEG-family-protein	gnl|CDD|226311	COG3788, COG3788, Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only].	8.87149e-06
NC_014666.1|WP_013422695.1|1877984_1879010_+|ABC-transporter-permease	gnl|CDD|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	3.10524e-99
NC_014666.1|WP_013422697.1|1879923_1880823_+|ABC-transporter-ATP-binding-protein	gnl|CDD|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	8.10454e-110
NC_014666.1|WP_157734855.1|1881684_1883091_+|hypothetical-protein	gnl|CDD|377179	pfam03972, MmgE_PrpD, MmgE/PrpD family. This family includes 2-methylcitrate dehydratase EC:4.2.1.79 (PrpD) that is required for propionate catabolism. It catalyzes the third step of the 2-methylcitric acid cycle.	5.88361e-85
NC_014666.1|WP_013422700.1|1883120_1883585_+|nucleoside-deaminase	gnl|CDD|238612	cd01285, nucleoside_deaminase, Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on the substrate. The functional enzyme is a homodimer. Cytosine deaminase catalyzes the deamination of cytosine to uracil and ammonia and is a member of the pyrimidine salvage pathway. Cytosine deaminase is found in bacteria and fungi but is not present in mammals; for this reason, the enzyme is currently of interest for antimicrobial drug design and gene therapy applications against tumors. Some members of this family are tRNA-specific adenosine deaminases that generate inosine at the first position of their anticodon (position 34) of specific tRNAs; this modification is thought to enlarge the codon recognition capacity during protein synthesis. Other members of the family are guanine deaminases which deaminate guanine to xanthine as part of the utilization of guanine as a nitrogen source.	2.78733e-28
NC_014666.1|WP_013422714.1|1898446_1899364_-|NAD(P)-dependent-oxidoreductase	gnl|CDD|223528	COG0451, WcaG, Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism].	1.37669e-19
NC_014666.1|WP_041259018.1|1887838_1888513_-|response-regulator-transcription-factor	gnl|CDD|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.11619e-77
NC_014666.1|WP_013422696.1|1879006_1879927_+|ABC-transporter-permease	gnl|CDD|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.43698e-78
NC_014666.1|WP_013422704.1|1886411_1887839_-|HAMP-domain-containing-histidine-kinase	gnl|CDD|273593	TIGR01386, Probable_sensor_protein_PcoS, heavy metal sensor kinase. Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.	1.25532e-46
NC_014666.1|WP_049807129.1|1899457_1900336_+|acyl-CoA-thioesterase-II	gnl|CDD|224857	COG1946, TesB, Acyl-CoA thioesterase [Lipid metabolism].	2.93108e-71

Protein sequences

>NC_014666.1|WP_041259018.1|1887838_1888513_-|response-regulator-transcription-factor
MRVLLVEDEERLAGLLRGGLAGEGFAVDVAHNGQEGLWMATENRYDAIVLDVMLPLLNGYAVCRRLREDGNWTPIMMLTAKDGEYDEAEALDTGADDFLSKPFSYVVLLARLRALIRRGGRERPVVLTAGDLAVDPAGLRCRRGETEIALTPKEFAVLHALARRVGEVVSKAELLEQAWDFAYDGDPSIVEVYISALRRKIDAPFGRASLVTVRGAGYRLDGAC
>NC_014666.1|WP_013422704.1|1886411_1887839_-|HAMP-domain-containing-histidine-kinase
MRSVRLRATVVATVTVALALGTAGLVLVLVLRGSLVSGASQEAARRADEAAAVLTQGAETDQPGRPALVITNVVGPDPDVKVISAANIEVAGQTGSQSMGTGAGTAGQVAWGSGYATAQRQVATAAGPVTVSARVSLDPADAALAMLRNLLLAGLPVLLLLVAGLTWLLTGRALAPVSAIRATFADITATDLHRRVPVPHSGDEIARLARTMNATLDRLQQAVERHKRFVADAAHELRSPLAILRTRLELGQREAPCLVEEALTDVDRLQNLAADLLLLARLDAGEPLRVDEVDLGEVAAEEALRPRRGDVQVTLDIAPDVVVTGSASHLRRMVGNLVDNAVRHAASTVVVRVAAPATVQVSDDGPGIPAQHRESVFDRFTRLDETRARDGGGSGLGLAIARDIAHAHGGTLTATEPDHPPGHAVTGACLRAELPTAARRLAGALPIVAAVDVAAVPGERDRLAVAGVPAVREVP
>NC_014666.1|WP_041259014.1|1884989_1885625_-|hypothetical-protein
MVTTALPKDSWLRALRPQPARVTAAEYEALSEEIARSIEIVDGYIVFCEAPTPDHQTAGRRLANLLERHAQNAVKSGRYGCLTVNNDVDLRLRDIPLLNRRPDVILSRCLDRDRGERPRAEHALLVIEIVSPGSETQDTTDKLGEYARAGIPHYWITRLDNDGVTTIERYALDHASMLYKHLGTLMKDEAGGPPAITNPIPVTITWDDLTF
>NC_014666.1|WP_013422701.1|1883586_1884930_+|amidohydrolase-family-protein
MEPTRRSFPTASQAFLAKRIFTAVGAEGTLIEDAALVLEDNQILYVGPAREVELAAVPVHDLGDVTVLPGLVDAHAHLTLPADKRNYEQVHQDPDEMLALVCVMNLRKHLAAGVTTIRDNGGRNRVTFTVRDAIRRGYLAGPRLLLCGRPVTQRLGHFYFCGGTADGPVEIRATVRALVAEGADHIKIMASGGATLGNLPYYAAYTVEEMKAAVDAAHDLGRLTTGHCRATQSMRYALEAGFDAIEHAEFLEADLSRKANLGAHHNLQGGQSVYDGRLAQQLLDAGTFISTTLQCGGYDTVVDLRHKKDTAGLTGQEQGQLDALQFYFEQKVGNFSQLIKDGFVGKLAISSDAGPFDTQFGRMDLGLCLGVEGGMTTGQALVAATRVGAELCGIADEVGTLEPGKLADFFAVDGDPTRNIADIANVTGVWADGRLRSHGPGVGVEWP
>NC_014666.1|WP_013422700.1|1883120_1883585_+|nucleoside-deaminase
MTISVQDAMKRSLELAAEAAAAGDNPYGAVLVTADGQAVEERNRVVTTSDPTAHAESMAIRVAAKTWGIDLSGATMVASFEPCPMCCGAILEAGITVLAIGQRRTVGEAPLGRYTVENLLELVDRPHALQVVTGEFGDEAAAFYATVGSTTEEA
>NC_014666.1|WP_157734855.1|1881684_1883091_+|hypothetical-protein
MTERPPVTRELAAFAAGLRFEDLPSSAVAMARMHTLNIVTAAMTGSTLPAAASVLTVHLRAGGVPESSVIGGERRLPRAAAAAVNAHSAYCTMNDDSFMEGDLHPGHSAVTAALAVAESVGAGGKDFLLALVAGIEVGCRIGASLCQTQESHKARAGWHCNLGDTFVAAVAAGKLLGLSEDQFVAALGIAATAAAGLNEVMNPPPSLVWPWDGGRNTGQGVLAAELALAGMTAGTTALEGHQGFIEMFTGGRAEPVAFDRALRGLHAEWISEQLLIKTRSASVMTHSAIDAAQHLVLHHQVALAEIETIEVRTNRWTAEKLCHRDIPDFNVSVFSLPFAIALAILTGDRLSPPSSHQAYLDNVEIRSLMARVVAIEDPEIDKVFGFSLPADVTVRTTDGRRYRAREDIPYGQYPHKPLDPEVFERKLRLNAAPLLRADRVDRLIDWVSDELTSARTLEPLARLIAPSS
>NC_014666.1|WP_013422698.1|1880819_1881641_+|ABC-transporter-ATP-binding-protein
MTALLEVDGLTKSFGRGRKRHQVLHDVSFSVPAGRVVGIVGQSGSGKTTAVRCVLGLDQPDAGAVRYDGFDVLAAGRAQRRRFQTEVQTVSQDPYTSLDPRMRVEKIVGEPLWIGGLRDRAALRARALEALALVGLPDDAGSRFPRAFSGGQRQRIAIARALITRPRLLVCDEAVSALDVSVQAEILNLIRTMQRQLSLSVLFVAHDLAVVKYLCEHVVVMSEGRVVEAGSREAIYDAPATEYTRRLLAAVPRTDPAAERARRHARLSAGAGR
>NC_014666.1|WP_013422697.1|1879923_1880823_+|ABC-transporter-ATP-binding-protein
MKPRAIDRDIEPFLRVRKLRATVAAPGHRPELGERELVRGIDLDVWPGERVALVGESGSGKSVTARGILQLDPSLRLTGSVEVARQQLIGAAPGTVRGIRGRVVSMVFQDPMTALNPVLTVGDQVAEPLRLAGTSRKEAMRQAADMLDRLGVPNARTRLGAYPQEFSGGMRQRVVLAAALIGQPSLLIADEPTTALDVLVQEQILDLIVRQSDELRLAVLLITHDLGLVAGATDRVYVMRSGEIVEEALVDDLFTHPGHSYTRALLGAVPTLDHDPEVPLAPVPAAGAEPEQCLPRSRR
>NC_014666.1|WP_013422696.1|1879006_1879927_+|ABC-transporter-permease
MNNANPDITFVAPRRLPRLETRRLVGAPARALRGLAGRHAPWLDRIAVGILCLVLLVSVVGAFWRPADPYTANPKTALLGPSAHHLFGTDDVGRDVLSRMLAGAPETLLAALGITLLATLVGVVLASVAALSPRWLDAAVMRLCDITLALPTLVLALGIAAALGPSNRSLTIAMVLSLWPGTARLARTTIRETMSQPYIETARRMGAGRLSLLFRHILPNSLDQIVVTASMEIGGAIVIMAGLAFIGVGAPPPDANWGSMVAEGQSYMTTAWWISMFPGLVITLSAMAFGVIGDAIRVRIDPAMVR
>NC_014666.1|WP_013422695.1|1877984_1879010_+|ABC-transporter-permease
MRNFVVARLGQAILCVWGVVTIVFALTKVIPGDPARIAAGQTATPAQIDQARAALGLNHPWIVQYLDFIGRAFRGDLGTSTVTHQPVMHDLAQTIPTTIQLVAIGLLIIIVLGIPIGVLAACFENRPIDGALRVFLAFLGGAPVFWVAILIQFVFAAKLRIVPISGSNDYGLAPAHHTGFTLIDSLVDGNASEFFNSLTHLLLPAFALAAPFLAHLARNVRTTMIGALRTDYVTFAHSKGLDTRRVVFHHALRATLASSITMLGMQFGWMIGSALLVETVFGLPGVGTYLNQAVLSQDIFAVLGGVLIIGVVFIVSSLIVDLVQIRFDPRVRATMLAEAAR
>NC_014666.1|WP_013422707.1|1889334_1892151_-|AAA-family-ATPase
MAADDRFVGRQDELDLLRRRLADARAGSGGVVMVSGPAGIGKTRLIEELVAEAAPTPVVWGSAVADQGAPPLWPWTRALRGLPGPRDALSAVVAGDAQREHGSAQDAAATTFAADTQVIDALAATAAAAGLVIVLDDLHWADRATLRLLARVATEVRRLPVLVVGAHRGALAGALDALPRHGATDDVHLGPLAPAEAGAYLTSAVARSDPRAVRRAIELSGGNPLYLRTLSRVAAGPLRGDGGWAAAVGEAAEFRGLVTAAMRSAGPVAADAVEALSVLGAEADPALLGGLIGVDAGVAAHRLLPAVPTGLVEVAPVAGAPVRFAHSLVHDAVYASLAPRRRLTLHRRAAELLEPLARGRDERAGAVARHWARADEPSRAAGWAVRAADAARAAGAYDEAASYLESALDAADRAPADCGVDTTEVLLDLARAQYLGGHITAALASCERAATDGERSGRADVVARAAITVQGIGHPDTNARVEALCRRALAVGATGTAVLRSRIQAALACALIELGQVDEAARWSAQALVEAEATGDTDAELDAIHARVMVAWRPDQADEVYALGGRAIDLAGPTERPLARLWAHAWRSDRAVHRADLAAARIEVEAMRALAAQTGLPLVRWHLLRRRASFAALAGDFDGCRRLGGEAFALAVTWHDTSAHYIHLGQTVGLAMVRGDRTDLAAGWDLHLAEVHSLPPVARALLAAALHLAGRDAEAFDLYEPLLPVLVAARTAHDAAALTYLAFLATEFGDVPGCVKVRDWMAATLTTTLAVGAGSVFFYGATARVLGQLELGAGRPEAAIPLLEEGIRVDARLGARPFVVHGRLALARALTATGAIRPAAELARQAAADARRLDLPGPLRAADALIADAAGLARATDPLSDRENEVLALVAQAMSNRDIARALVLSERTVESHMRRILAKTGCANRVELARWRERRRS
>NC_014666.1|WP_013422708.1|1892310_1893282_+|glutathione-synthase
MKIAFVADPLESLDATVDTTVGLMHAAQDRGAEVWATEAVRLEAVRGRARAQARRVRLAPTHPAGGCRWSVADAWFTASAPTIVWLDDMDALFMRTEPPLDATYTTATLILDLLVPARTALINDPRGLRACSEHLLALHFDDLIPPTVVTADGDTIRDFLTQHGTAVLKPVDGFGGRGVLRLDRHDPNLASLLELATAGGTRAVVVQRFLREVAAGNKRVFVIAGEPVGAVYRYPAAGDFRIGDATAQAPITDRDREICARLAPVLRANGIHLAGLDVIGPHLIEVNVTSVGALRKADALLGWTLCADLLDSVLPAPTLERSA
>NC_014666.1|WP_013422709.1|1893278_1893677_+|MAPEG-family-protein
MTIAISCAAILGALVFGLGFNVSRLRGIVGKAGGAQQPTDPTDRLFVAVRAHGNAAEYVPTLMVLFLLVGERSPAAVAIPLIIGATVARLAHVVGMLTTPDWSIPTRSRLVGALGTYLFGVALAIAAAVTLL
>NC_014666.1|WP_013422711.1|1894901_1896038_-|Fic-family-protein
MLYPTPPRTPADDRVLAEIDVMRQALRHQIQTTPSKWTAGLRKFLTADAVAASNSIEGFKVSTIDVEDLIDGERDVEVSEENRDETLAYERMMAYIQTLHDAQDFSYSKGLFNALHWMLQGHRHTARRPAGQWRRGPVYVTDARDPSIAAYTAPDVDTVPALMKELVDWLDTDDDAHPLVRAAMAHLHLVSIHPWADGNGRMSRSLQTLMIAREGVLAPEFSSIEAWLGRPGNTWEYYRELAGRGPTYVPDQDVASWIRFNLTAYHQQAQTVQGRLDRSGRVWGALSEFAAATGLDERVVTALHDVAMAGRVRRSRYEEAEGLSLQQAQRDLRDLTTAQVLVPVGRTRARYYTAGPRFPQPALDLAGTPMTLRDPYSG
>NC_014666.1|WP_013422712.1|1896101_1897295_-|DUF1214-domain-containing-protein
MTALPTWTDQLRALEGVAENLIATWRPDGATEAETQDMNKLALSILADGYLCHVYTDARRPVFMPLWNFACNQGGPNPDYVYLTTEVDPAGVYEISGFRGTTRFVEITQQESEMTSPKHFERRTGPPLRVTNDLDELTIGADGSFRVTLSARRPDGHDGDWWPLDPRTRKLLMRKCACDWTHEVDARVAINRLDDPGADMTPAESAGRFSDLAEWIDGMIRFDMQLVRYYREHHGINVLLRSQWIEDAGGLAKQAYYDGIHQIADDEALIVEFPVPTECHYWQILVADDRFSTVDWVNRQSSLNDFQARVDPDGWFRAVVSRQDPGVHNWLDKADFPWGILQARFYRANEYPKATVTKVPVADVLKHLPPDTVVVTPAERAQQLRIRREGAQLRRIW
>NC_014666.1|WP_013422713.1|1897299_1898442_-|sulfotransferase
MRRYPSANQLLDEAAAQAGLADFGPGDFRDGLAVLLDSLERDGDLDPGTDAAVIGDFRRRLVNRLKVEAWYGEHPEVADVPVLGPVDINGLPRTGTTALADMLSLDPRFRCLRGWEQAEPCPPPTPDDEANDPRRLEFIAVQERRSPESRAKHLVEVDATMEDTELLGMAFHGQQMVLPVAGYRDWWREADLTSTYQYHRRVVKLLGSRRPPQLWLFKAPHHKFHLEALAAAYPDIRFVMTHRDPAKVVPSYSSLVSSITPPAAGERDLHRLGREISDHLRSGLLHAIDARKSLGEDRFLDVHHRELVADPKGTVRRIYAWLGFELTPAVERTILDWQQANRMGAAGTHRYTAEQFGLSTAQIRADYDFYIRHFDVAVEG
>NC_014666.1|WP_013422714.1|1898446_1899364_-|NAD(P)-dependent-oxidoreductase
MLSGEKILITGPTGRIAFGLAETLAADNEVWGIARFGDPAARAEIEALGVTTRAVDLGDGDFGDLPSDFTYLLHIAADFGNDYERALRVNGEGTGLLLAHCRTAKAALVMSTLTVYKPHPDPWHPFREDDPLGDAGLPEPRPYSIGKIAQEAVARYCARAFDLPVTIARMGSAYGARGGLPASSLHAIAAGRPVTARWDPLPYSPIHYDDINAQCEALLAVASTPARIVNWSGDEPVTVQQWSAYFGELLGVEATVAVEPVPGASLGSVGDHARRSTITGPCRVDWRDGFRRMAAHFYPDRVKAS
>NC_014666.1|WP_049807129.1|1899457_1900336_+|acyl-CoA-thioesterase-II
MLDALDGLLRALEPEQLAEDRSQVPPDTVSTAGRVYGGQLLAQALIAAGRSVTGKAPHSLHASFVRAGTPGRPLELATDRVRDGRSMATRQVTVTEDGKPLLVAIAAFHGADPGPGAAVSAPAVPPPDELPGLQQWAAELPADLREYGRHWIERPPPIEFRMAEAPSFLGGPRAGMAASASRSHWMRLPRSVGDDPLLHLALLAYASDFLLMDMIFRGHPGAAGPGRCNGLSLDHAIWFHRPTRFDQWHLHTQEAVTIVGNRGLVRGAIHDADGQLVATVMQEVLVIPEATR
>NC_014666.1|WP_013422716.1|1900332_1900905_+|glyoxalase
MSPIEHRLFQQSWPEGEYRFFQQGFLVDDVLAAAARWARVFGVGPFHVMPAFDQTALHRGAEATITLQVAVAQAGPVQIELIQQHCDRPSVFRDWSRGGTCAFHQLATVTPDYDKKKAHYEGLGYEIVTESLSGRFRVAFVDTVADFGFYTEVVESTPGFLANLGKIARASEAWDGTDPVRMLGPDGRVK
>NC_014666.1|WP_013422717.1|1900965_1901634_-|GntR-family-transcriptional-regulator
MASRPIPRKKTSPAVVDYILEQIFEGHLKSGDRIDLDQVCRDLDVSRLPVREAIVMLERDGLVTSTYHRGVFVEPFDAKSVIDDFEIIGLLSGVAVRRLAEEQDREVITELEGLVDELRAAPAGDRDRTIELVRTILTTEHRAGGSRRLRAELRAFTGYLPLVFRISTNRSHDEIVEAHARVVRAVAAGDGEKAARYRVDDFRDAGRKVVQELARRGVLSGE

Crispr_ID: NC_014666_6

• CRISPR_ID: NC_014666_6
• CRISPR_location: 2348228-2348357
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_014666_6

Consensus_repeat	Method
GTGACCCTCGGGCCGCCGACGTTCGACGACGGGACCA	CRISPRCasFinder

spacers of NC_014666_6

>6.1|2348265|56|NC_014666|CRISPRCasFinder
CCACCACGGCGAACGCGGACGGATCCCTGACGGTCACCGGGCCGGATGGGACGACC

CRISPR arrays and Neighbor proteins around NC_014666_6

CRISPR arrays

The CRISPR arrays of NC_014666_6

>merge|NC_014666|6|2348228-2348357|CRISPRCasFinder
GTGACCCTCGGGCCGCCGACGTTCGACGACGGGACCACCACCACGGCGAACGCGGACGGATCCCTGACGGTCACCGGGCCGGATGGGACGACCGTGACCGTCGGGCCGCCGACGTTCGACGACGGGACCA

>NC_014666|6|5|2348228-2348357|CRISPRCasFinder
GTGACCCTCGGGCCGCCGACGTTCGACGACGGGACCA	CCACCACGGCGAACGCGGACGGATCCCTGACGGTCACCGGGCCGGATGGGACGACC
GTGACCGTCGGGCCGCCGACGTTCGACGACGGGACCA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_014666.1|WP_157734880.1|2344491_2345469_-|SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|252734
NC_014666.1|WP_013423090.1|2341196_2342087_+|CoA-transferase-subunit-A	unknown	unknown	gnl|CDD|224702
NC_014666.1|WP_041260501.1|2342116_2342902_+|CoA-transferase	unknown	unknown	gnl|CDD|224968
NC_014666.1|WP_041259125.1|2348751_2350347_+|DUF1957-domain-containing-protein	unknown	unknown	gnl|CDD|212104
NC_014666.1|WP_013423088.1|2338964_2339975_-|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl|CDD|366009
NC_014666.1|WP_013423093.1|2344004_2344466_+|hypothetical-protein	unknown	unknown	gnl|CDD|239534
NC_014666.1|WP_013423092.1|2342898_2344008_+|nitronate-monooxygenase	unknown	unknown	gnl|CDD|240081
NC_014666.1|WP_013423087.1|2337191_2338478_-|sensor-histidine-kinase	unknown	unknown	gnl|CDD|340391
NC_014666.1|WP_013423086.1|2336739_2337183_-|roadblock/LC7-domain-containing-protein	unknown	unknown	gnl|CDD|214939
NC_014666.1|WP_013423095.1|2345960_2346605_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228
NC_014666.1|WP_013423100.1|2353602_2354685_+|alcohol-dehydrogenase-catalytic-domain-containing-protein	unknown	unknown	gnl|CDD|176240
NC_014666.1|WP_013423098.1|2350470_2351604_-|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl|CDD|225052
NC_014666.1|WP_013423099.1|2352055_2353516_+|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|143408
NC_014666.1|WP_013423103.1|2360798_2362220_+|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|380564
NC_014666.1|WP_013423089.1|2340006_2340915_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|236099
NC_014666.1|WP_013423102.1|2358668_2360423_-|amidohydrolase-family-protein	unknown	unknown	gnl|CDD|226179
NC_014666.1|WP_013423106.1|2365776_2366088_+|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl|CDD|224278
NC_014666.1|WP_013423104.1|2362216_2363959_+|AMP-binding-protein	unknown	unknown	gnl|CDD|236100
NC_014666.1|WP_013423105.1|2363955_2365578_+|AMP-binding-protein	unknown	unknown	gnl|CDD|235731
NC_014666.1|WP_157735358.1|2356853_2358635_+|patatin	unknown	unknown	gnl|CDD|132846

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_014666.1|WP_157734880.1|2344491_2345469_-|SAM-dependent-methyltransferase	gnl|CDD|252734	pfam04672, Methyltransf_19, S-adenosyl methyltransferase. This family contains a SAM (S-adenosyl methyltransferase) domain, with a central beta sheet with 3 alpha-helices on both sides. Crystal packing analysis of the structure Structure 3giw suggests that a monomer is the solution state oligomeric form. An unidentified ligand (UNL, cyan) was found at the putative active site surrounded by the residues His57, His170, Phe171, Tyr216 and Met22. The UNL is likely to be a phenylalanine or phenylalanine-like molecule. (details derived from TOPSAN).	4.14303e-108
NC_014666.1|WP_013423090.1|2341196_2342087_+|CoA-transferase-subunit-A	gnl|CDD|224702	COG1788, AtoD, Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism].	3.79805e-57
NC_014666.1|WP_041260501.1|2342116_2342902_+|CoA-transferase	gnl|CDD|224968	COG2057, AtoA, Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism].	1.92409e-25
NC_014666.1|WP_041259125.1|2348751_2350347_+|DUF1957-domain-containing-protein	gnl|CDD|212104	cd10792, GH57N_AmyC_like, N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins. Alpha-amylases (alpha-1,4-glucan-4-glucanohydrolases, EC 3.2.1.1) play essential roles in alpha-glucan metabolism by catalyzing the hydrolysis of polysaccharides such as amylose starch, and beta-limit dextrin. This subfamily is represented by a novel alpha-amylase (AmyC) encoded by hyperthermophilic organism Thermotoga maritime ORF tm1438, and its prokaryotic homologs. AmyC functions as a homotetramer and shows thermostable amylolytic activity. It is strongly inhibited by acarbose. AmyC is composed of a N-terminal catalytic domain, containing a distorted TIM-barrel structure with a characteristic (beta/alpha)7 fold motif, and two additional less conserved domains. There are other two canonical alpha-amylases encoded from T. maritime that lack the sequence similarity to AmyC, and belong to a different superfamily.	0
NC_014666.1|WP_013423088.1|2338964_2339975_-|LLM-class-flavin-dependent-oxidoreductase	gnl|CDD|366009	pfam00296, Bac_luciferase, Luciferase-like monooxygenase.	1.14319e-25
NC_014666.1|WP_013423093.1|2344004_2344466_+|hypothetical-protein	gnl|CDD|239534	cd03450, NodN, NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their legume hosts, a symbiotic process that requires production of Nod factors, which are signal molecules involved in root hair deformation and meristematic cell division. The nodulation gene products, including NodN, are involved in producing the Nod factors, however the role played by NodN is unclear.	2.65784e-21
NC_014666.1|WP_013423092.1|2342898_2344008_+|nitronate-monooxygenase	gnl|CDD|240081	cd04730, NPD_like, 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase family that reduce a range of alternative electron acceptors. Most use FAD/FMN as a cofactor and NAD(P)H as electron donor. Some contain 4Fe-4S cluster to transfer electron from FAD to FMN.	1.6415e-77
NC_014666.1|WP_013423087.1|2337191_2338478_-|sensor-histidine-kinase	gnl|CDD|340391	cd00075, HATPase, Histidine kinase-like ATPase domain. This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.	3.8684e-19
NC_014666.1|WP_013423086.1|2336739_2337183_-|roadblock/LC7-domain-containing-protein	gnl|CDD|214939	smart00960, Robl_LC7, Roadblock/LC7 domain. This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.	4.48055e-19
NC_014666.1|WP_013423095.1|2345960_2346605_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.15276e-12
NC_014666.1|WP_013423100.1|2353602_2354685_+|alcohol-dehydrogenase-catalytic-domain-containing-protein	gnl|CDD|176240	cd08279, Zn_ADH_class_III, Class III alcohol dehydrogenase. Glutathione-dependent formaldehyde dehydrogenases (FDHs, Class III ADH) are members of the zinc-dependent/medium chain alcohol dehydrogenase family. FDH converts formaldehyde and NAD(P) to formate and NAD(P)H. The initial step in this process the spontaneous formation of a S-(hydroxymethyl)glutathione adduct from formaldehyde and glutathione, followed by FDH-mediated oxidation (and detoxification) of the adduct to S-formylglutathione. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. Class III ADH are also known as glutathione-dependent formaldehyde dehydrogenase (FDH), which convert aldehydes to corresponding carboxylic acid and alcohol. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of an beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding.	2.55319e-154
NC_014666.1|WP_013423098.1|2350470_2351604_-|LLM-class-flavin-dependent-oxidoreductase	gnl|CDD|225052	COG2141, COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion].	9.15158e-54
NC_014666.1|WP_013423099.1|2352055_2353516_+|aldehyde-dehydrogenase-family-protein	gnl|CDD|143408	cd07089, ALDH_CddD-AldA-like, Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins. The 6-oxolauric acid dehydrogenase (CddD) from Rhodococcus ruber SC1 which converts 6-oxolauric acid to dodecanedioic acid; and the aldehyde dehydrogenase (locus SSP0762) from Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 and also, the Mycobacterium tuberculosis H37Rv ALDH AldA (locus Rv0768) sequence; and other similar sequences, are included in this CD.	0
NC_014666.1|WP_013423103.1|2360798_2362220_+|ABC-transporter-substrate-binding-protein	gnl|CDD|380564	cd06341, PBP1_ABC_ligand_binding-like, type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions. This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. Members of this group are sequence-similar to members of the family of ABC-type hydrophobic amino acid transporters such as leucine-isoleucine-valine binding protein (LIVBP); however their ligand specificity has not been determined experimentally.	3.70954e-16
NC_014666.1|WP_013423089.1|2340006_2340915_-|SDR-family-oxidoreductase	gnl|CDD|236099	PRK07791, PRK07791, short chain dehydrogenase; Provisional.	1.38514e-150
NC_014666.1|WP_013423102.1|2358668_2360423_-|amidohydrolase-family-protein	gnl|CDD|226179	COG3653, COG3653, N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism].	5.16709e-90
NC_014666.1|WP_013423106.1|2365776_2366088_+|antibiotic-biosynthesis-monooxygenase	gnl|CDD|224278	COG1359, COG1359, Uncharacterized conserved protein [Function unknown].	9.40912e-21
NC_014666.1|WP_013423104.1|2362216_2363959_+|AMP-binding-protein	gnl|CDD|236100	PRK07798, PRK07798, acyl-CoA synthetase; Validated.	0
NC_014666.1|WP_013423105.1|2363955_2365578_+|AMP-binding-protein	gnl|CDD|235731	PRK06188, PRK06188, acyl-CoA synthetase; Validated.	0
NC_014666.1|WP_157735358.1|2356853_2358635_+|patatin	gnl|CDD|132846	cd07207, Pat_ExoU_VipD_like, ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2. ExoU, a 74-kDa enzyme, is a potent virulence factor of Pseudomonas aeruginosa. One of the pathogenic mechanisms of P. aeruginosa is to induce cytotoxicity by the injection of effector proteins (e.g. ExoU) using the type III secretion (T3S) system. ExoU is homologus to patatin and also has the conserved catalytic residues of mammalian calcium-independent (iPLA2) and cytosolic (cPLA2) PLA2. In vitro, ExoU cytotoxity is blocked by the inhibitor of cytosolic and Ca2-independent phospholipase A2 (cPLA2 and iPLA2) enzymes, suggesting that phospholipase A2 inhibitors may represent a novel mode of treatment for acute P. aeruginosa infections. ExoU requires eukaryotic superoxide dismutase as a cofactor and cleaves phosphatidylcholine and phosphatidylethanolamine in vitro. VipD, a 69-kDa cytosolic protein, belongs to the members of Legionella pneumophila family and is homologus to ExoU from Pseudomonas. Even though VipD shows high sequence similarity with several functional regions of ExoU (e.g. oxyanion hole, active site serine, active site aspartate), it has been shown to have no phospholipase activity. This family includes ExoU from Pseudomonas aeruginosa and VipD of Legionella pneumophila.	2.62845e-05

Protein sequences

>NC_014666.1|WP_013423095.1|2345960_2346605_+|TetR/AcrR-family-transcriptional-regulator
MSETVAAAATSPAKGVPATTATPSQQARRERMLSAALALASQGGYDEVQMREVAEQAGVALGTLYRYFPSKVHLLASALARHLSGLREAVLDPLPGSADPPTRVMAMMNRLVDELSRDRLVAEALIQAMTLASATVGTEIDDVDEAMIGLIGVAAFGPDHVVDERDKLITNIIGKVFLSDLRYWLGDRMTLEGVRASLGDTVAVVLAGQQALVR
>NC_014666.1|WP_157734880.1|2344491_2345469_-|SAM-dependent-methyltransferase
MAPAWLVATVPAGSTARERRTHATSGKGSLVADSGTDEGRSWDFQSAIAADEVTPGPDGEPVDLRTDVAHVARIYDYWLGGKTNYPADREVAEKVLAAMPSTTQSVRANRSFLRRAVHLLAAERGIRQFLDIGTGVPSADNTHEVAQRAAPDARVVYADNDPIVLAHAQALLTSTTDGATAYVQGDVREPGALLAKAAELLDFSQPVALMLVAIMHCVSDDESPYDVVRTLAEALPAGSYLVLSHPGIASAGAQTSTPSADALAAAALLRSASAGATITFRSQEQVVPFFDGWDLLDPGVVLATKWRADEPEQTIVWAGVGHKPA
>NC_014666.1|WP_013423093.1|2344004_2344466_+|hypothetical-protein
MSRPAAAPLVLTGVDAVRAAVGRELGPAGPVLVGPERVAAFETATGWPAGPPSTCAGPTSGRAVPKLLLLSLVNDVLPRLVDVRGFAMGVNYGTGPVRFPAGLPVGGAVLGSLMITEVADVPGGVQVTFRVTLTAGDTDHQVCVADSLARYLD
>NC_014666.1|WP_013423092.1|2342898_2344008_+|nitronate-monooxygenase
MSGDPRLETAFTRLTGARYPIVQTGMGWVSGARLTAATSAAGGLGILGSATMTLDQLAGAVRAVKERTDAPFGVNLRSDAEDVEDRVALMVREGVRVASFALAPRKDLFARLRDAGIVTMPSVGARRHAEKVASWGADAVLVQGGEGGGHTGAVPTSLLVPQVVDAVDIPVVAAGGYFDGRGLVAALAYGAAGIGMGTRFLLTADSTVADNVKAHYLAAGVDGTVVTTRVDGVPHRVLRTPLVDGLTSAGPLTRFPRAIRNAAAFRRASGATWRGLLREGRALRSHGGLTWSQVLMSANTPMLLRASMVEGRDDLGLMTSGQVAGLIDDVPTVEELVGRIVAEAAAVLDRLAASGAAAPRPVAVAPEPG
>NC_014666.1|WP_041260501.1|2342116_2342902_+|CoA-transferase
MPAVGGPVARRADVCALACAEAFRGAGEILASAFGTAPALGARLARLLFAPDLVLSDGEAMLLANTPPLGAPPSEAVVEGWLPFRSVFDVVAAGRRHVIMIPSQLDAFGNMNISAVGPHARPKAQLIGTRGAPGNTVNHATSYWVPRHGPRVFVERVDVVCGVGYDRARAAGPSATRFHGLGRVVTDLAVLDFASPDNRLRLASVHPGVTVDEVLAATGFPLVLPAAGSDAVPVTPEPSAAELDLLDVLDPKGLRYREVAA
>NC_014666.1|WP_013423090.1|2341196_2342087_+|CoA-transferase-subunit-A
MGAKLTTVGAAVAAVESGMTIGIGGWGSRRKPMALVRALARGPATDLTVVTYGGPDVGLLAAAGKIRVLVSGFVSLDSIALEPHFRAARQRGEIEFRELDEGMLQWGLLAAAHRLPFLPIRAGLGSDVPATFPGLRTVRSPYPDGEELVAMPALPLDVAFVHANRADAAGNAAFLGPDPYFDDLFCLAARHRVLSCERVVETAQLTKEAPVQALRINRMMVDAVVETPNGAHFTSCVPDYDRDETFQRAYVAAAAAGGGSQDWAAFHERYLAGDEAGYQAAVRAQQSLRGEKETGR
>NC_014666.1|WP_013423089.1|2340006_2340915_-|SDR-family-oxidoreductase
MGEGGVCAGRVVIVTGAGRGIGRAHALEFARQGARVVVNDVGVALDGAAAGEPVASGVVEEIRALGGEAVVSTDDVADWSGAEALVRTAVDTFGRLDVLVNNAGFVRDRMLVSMTEQEWDAVVRVHLKGHAAPLRHAAGYWRDEAKAGRRPDARIINTSSGAGLQGSVGQGNYGAAKAGIAALTLIAATELARYGVTANAIAPSARTRMTEGVFDTMAPVESGFDAMDPANIAPLVVWLGSERSAHVTGQVFEVEGGKLAVASGWRHGVPIDRGARWETAQVGVAVDKLLAAAPPAEPVYGA
>NC_014666.1|WP_013423088.1|2338964_2339975_-|LLM-class-flavin-dependent-oxidoreductase
MLSVLRFNFAVPGLDRGALAAAYQAGIEMASYADEAGIPMVSLEEHHGADNGWSPAPLVNAGLILGATKRVHVIVQALLVPLSDPLRLAEQLAVLDLAGRGRITAVAGLGYRPVEYADAGLDWSRRGALMDESLTAMLAAWTGEPFEYRGRTVRVTPPPASPPAQLLWVGGSAKVSARRAARLGLPLCPANNLPELEAYYYEQCTQQGTSGFVVMPPAETAFVHVAEDPDKAWAELGEHFLAEATLYSSWQPEGQTSAAHSHATTVDELRAEGRYRILTPDECVRRGLSAGPGELGPVTVLHPLCGGMPPERGWESLRLFVEKVLPRVAAEAAPTG
>NC_014666.1|WP_013423087.1|2337191_2338478_-|sensor-histidine-kinase
MTTRARELLNRSRALLGGSREAAAQLLAPPPTRSTPARSVRTQPPAGSRVPGVRAAATPSPAEEALSAICADLALRDLNLVDTLLAQLEEMESREEDADRLAELYRLDHLAARLRRNAENLRVLAGRDAGEQGSQTSSLVDVIRGAMSSIDHYQRVTVGRVVNLGVVGFAAEDVSRLLAELLDNATKSSPPHSPVRVGAHLTETGSALLRIEDEGIGLPAERLRQINQRLTADPVLDDDAVRHMGLAVVRRLATRHGIKVWLDHRHPHGTTGSVLLPAPLVCELPDAGWSGLQTVSVPAGADGPRQSGDVEDRMVSAALNGNGSRPAAGTRGAGRLPARRAEPAPASPPPAAASAGTTASGLPRRVSHSLRDTYGDAIGARTAARAGTGAPEGAAEAVDPTVGHKQLLADLGAFSEGERAARDERRAD
>NC_014666.1|WP_013423086.1|2336739_2337183_-|roadblock/LC7-domain-containing-protein
MTQEHTGHPETDFTWLIDDFVRKVHGVTHALIMSSDGLSLTSSQEMTTEEAERLAAIASGMLSLARNSAALFGKGTCEQIIVRLSQGYFLFMGIDAGAGLAVLTSPDCDMKVVAYEMTQFVMHAGHALTPELRADLRRVLVGRRPSG
>NC_014666.1|WP_041259125.1|2348751_2350347_+|DUF1957-domain-containing-protein
MTGQVVLALHAHLPFVRHVDDPNALEEDWLFDALTDCYLPLLGVLEGWAADGVTATMTVSLSPTLLAMLSDDLLRDRYSLRLTRLLSFLDGERRRFRTDETMRALVDFYAERLSSTYDRFHGRYSRDVVGAFVAMEKAGVARLITTSATHTYLPAFDQAYQRAQLRLGIRAFTERVGHRPEGLWLPECGFTPGLDTLLAAEGMRYFFVESHAVEYADPRPVFGTNAPIACPSGVVAFPRNQESTVMVWNADAGYPGDGRYREFYRDAGHDRAAADLEGLVLDDGKRRNTGIKYHRVTDRTLGLGDKHLYDREAGLAAAATHARHFVAARAHEASTVSALTGQPAVMAAPFDAELFGHWWFEGPEFLDVVGRACAARTDIGLADPMDVIAGTAGLQVAMPAASSWGWGGYSETWINEQNLWMWPHLRAAAARMAGVASAAGRPTALQRRVLNQLARELVLATASDWPFMVTAGTMGPYGERRVRTHLTRFQALLDQFETSAVDQLFLARLEADDNIFGSLDYQDFAAASGIS
>NC_014666.1|WP_013423098.1|2350470_2351604_-|LLM-class-flavin-dependent-oxidoreductase
MEFGIFNSLYLPKRLSDRDPIGAEHSRLMDEVAWTQAADRAGFKYTWATEHHFLDEYSHLSANEVFLAYVAGTTSNIHIGSGIFNITPPVNHPARIAERAAMLDHLSGGRFELGMGRGSSSTEQKGFGIEDPALTKLMFDEVVAELPKMWKDQPYAHDGQFFSMPERNVLPKPYTRPHPPLWVAAGNPGTFEKAAKMGLGVLCFANSSPEELAPLIETYKKNIEKAEPIGGYINNNIMVTSQMLCLQDGDRARQIATDITMSYQHSQVYRYLDTFPKPNWVPDWPATLPEPTVEILELGVRAGTICIGDPDEVERAVQSYVNIGADQLVFGMLSTTMPIEVAVEAVDTFGRHVLPKFDKDPVHSTTRQREAQLAAKA
>NC_014666.1|WP_013423099.1|2352055_2353516_+|aldehyde-dehydrogenase-family-protein
MGVPSSRIYLAGEWVEPAGGHYDVVNPATEEVVGTAPEASAQQAEQAATAAKAAFEGWASASPAHRSEVLGRVADLLTKYNDDLVPLVQAETGATMRVASTMQVPVAVERFSRYARHALESSLVALPPQAIDATPLAPGGLVGAVARRAPVGVVACITPYNFPLVNLAGKVAPALAMGNTVVIKPAPQDPLQVLRFAEIVHEAGVPAGVVNVVTGSGVDTGAALVASPDVDMISFTGSTAVGRRIGEAAGRDMKRQLMELGGKGAAIVFEDADLDRAASGIGSTWAFHSGQICTAPTRALVHRSVHDQLVEKLVGYAGFCPVGDPLLASTVVGPLISASQRDRVEALVAEGVGAGATVAVGGQRPELDRGFYAAPTLLTGVTPDMSVAQEEFFGPVVVVLAFDDEDEAVQIANGTPFGLYDYVFSGDTARAYRVATRLRSGNVGINTVARNHETPFGGFKHSGVGRDCGAFALQAYSELQSIVWPG
>NC_014666.1|WP_013423100.1|2353602_2354685_+|alcohol-dehydrogenase-catalytic-domain-containing-protein
MRGVVFDGQKAELVDDLTVRDPGPGEALVRIAAAGLCHSDVSVINGTIPFPTPVVLGHEGAGVVAAVGDAVGNVKVGDHVVLSTLGNCGACQHCDAGRPTMCRSTFGARPQPFTWRGEPAYNFANLSCFAEEIVVKANQCVPIPQDVALTSAALVGCGVVTGVGAVLQRAKVHPGSTVAVLGVGGVGLNVLQGARIAGAARIVAVDVNPAKEALARLFGATDFVDPTGVDTATVLKETIQDTEPTGYDYIFECVGHPALIRAAIDALAWSGSAVLLGVPAATTEASFNVAGMFLDKSILGCRYGSSQPQRDIRRYVDLYRGRRLLLDELVTRTYPLADFHRAVEDLEHGDLARGVLTLNP
>NC_014666.1|WP_157735358.1|2356853_2358635_+|patatin
MQGGITSGIVYPAAVAELHERYDFRSIGGASAGAIGAALTAAAQYGDYARRRDPARPGGFGPLSEAAQQVAAPGLLVGLFQPTRATAWAFGLLFGLQRAGSSWLGRLWVAAGWVSRYFAAQMLIAGGISFGALVGVLYGFGGSLDRQRWYGWLLIAVVLLVTSLLGLLAAVLVRALRTVRGLPGDFFGACSGMPVGRGGQAALTPWLHGQIQRCAGREGAVPLTFADLAGGRRADEKIALEMMTTDLSAAQPLSLPFAEGQFLYSPGEFGRLFPDDVLAHLEQVSTPVPTPEGVLGPTDLRTFPGPDLPVIVATRMSLSFPGLICAVPLWVQGLGRGGPVRHWFSDGGISSNFPMHFFDTWLPTRPTFGLDLVPTPRAKGKREPVREPGDPAMTATVAPPSPGGGAPVRRVAQINNLFGFLAQILDTTLNWRDTLLAELPGFSDRIRSIRLPDGTGGIHLTMTPAQINDLAASGAVAGQSLLTTFDWDDHLFARYTLLMRQLQQNLVGGGHADPGTVTKAFTPEFQRLLASLGEAAVPGDGATTYDAQWGVSARDRTLALLGLATGWAAAQPLSFIQGEDPTPPPVMRLRPKV
>NC_014666.1|WP_013423102.1|2358668_2360423_-|amidohydrolase-family-protein
MLDLVVHGGQLVDGTGAPPRAADVGVRDGRIVTVGPPGSVPAGDAAQTVDAAGKVVCPGFIDVHTHYDAQLWWDPSASPSSQHGVTTVLGGNCGFTLAPLRPRDGRPDPAEADYLRRMMARVEGMPLQALESGVAWGWESFAEYLDGLDGRTAVNAGFLLGHCALRRYVMGPAAIGSAADGDAVAAMAAGLHAALEAGALGLSTTLSGTHSDGDGQPVASRWAERDELLALARAVGEHEGTFLEGIVPGCLDMFSDDEIELLAELSAAAGRPLNWNVLTIDSAAPLRVPRQLEASRRARELGGRVIALTMPTLVPMNMSLGTFCALHLIPGWGEVMRLPIAARVDALRDEAVQARLLAAAHDPAAGVLLRLTDFGRYVIGDTYSPANDGLSGRVVADIAAERGREPFAVLVEIAAADDLRTVLWPMPTDNNPESWALRARTWQHEDVLLGGSDAGAHLDRMAGAPYPTRFLGDCLRGRRLVGLERAVAMMTGEPAAAFGLRGRGVVATGNAADLVVFDPATIDSEPARLVADLPSGAARLTAGSVGVEAVFVNGTRIVTGGRATGATPGTLLRSGRDTRTVSTR
>NC_014666.1|WP_013423103.1|2360798_2362220_+|ABC-transporter-substrate-binding-protein
MARRSSRPCPERPHPRRARRGLAGLPVLAAASALLLVIAGCTRSTNETETGGGDAGGSPTSAAPAAAAAGDFGTEKGICGPGSARTATGRGVTASSITIGTMGDPGSTVTPGLGQEFFDVADAFAAWCNKAGGINGRKIVVNKHDAKLTDVAARTLDACQTDFMLVGGGNVLDAPGVQPRIDCKLGAIPAYGVSPQSLNAPLQLRAAPNTANRYPVAGFLAMARMFPDAMNAIGISGSSLADIRPQGLRLQEALTQLGYKVADYQEPPALVTNWRPYVEELKGKGVQGYEAIGVQDLTPVVTAMNDVGLNLKYMIIENQLYDPKTIAGAKSTKFPPTWLVMDHLPFELAAQSPVTQEAVDLVHATVPNAKLTAFTALALSSWVLWAKSATACGDTLTVDCVLAKAGTQTAWTAGGLYPKIDLKPGEQEVSHCYLLMKVTADGFVYDKTATAPNQGFFNCSDKNVVTLTNPFTA
>NC_014666.1|WP_013423104.1|2362216_2363959_+|AMP-binding-protein
MTAGALPGSGPRPVNFADMLELVAGAVPDRPALVAGAVRLTFGELDARVDRAARLLRGAGVRPGDHVGLYATNRAEWVESMFACMKLRATSININFRYVVAELRYLVDNADLVALVVERRYLPTVAGVLADAPALRLVVVLEDGTDPADDGGLAALTGPGGALADRGIRLAGYEDTPAVNTPADDSPVRVPRSGDDRFILYTGGTTGMPKGVIWRHEDLFHAAIGRPLPDGSAPRELADILVHTASPPLHYLVMAPLMHGAAELSVLISIGTAGTILLWCGRHFDPHDVLRLAADERASTMTVVGDAMARPLADALAEAPGRYDLSGLLAFSNTGAPMSPRVRADLAAALPNVFLLDSYGASEFGHNGSAEAGGKRLFQLTPDTLVLDERLEPVAPGSPEPGRIARRGNIPLGYYKDEAKTASTFLRDARGVRWVVPGDLALVRADGTVELLGRGSAVVNTGGEKVFPDEVEDALKSHGAVFDTAVVGVPDERYGERVVALVALREASPGGPPTVADLIAHTRQRVAGYKVPKEIHLVDVIARNPAGKPDTVWARTTALRLSLAAAEAPAAAPAPAEVSA
>NC_014666.1|WP_013423105.1|2363955_2365578_+|AMP-binding-protein
MTTTADPTVTPARAPQVGDLYRPSFLPDLLIAALGRNPDRPAVYIGDVALTASEVAAEISRYAQAYASVGLRVGSRTAMLSPNRPEVLFAMGANMITGCRSTSLHPLGSLDDHVYVLTDAEVETLVVDEKFAERAAEYVRRVPTLRQVVTFGPTDLGPNLLELAAGFEPKPLKAPDVGPDDVGGLTYTGGTTGKPKGVMGTYRGAAAMTNIQLTEWQWPDEPRFLMCTPLSHAGAAFFIPVLLRGGCLVVLPGFEPGLVIEAIEKYKINSTMLVPTMIYVLLDHPKLATTDVSSLKTIYYGAAAMSPTRLVEAIGRFGPIFFQYYGQSESPMTITVLRKEEHDLSRPERLASCGRPVPWVRVALLDEDGNEVPDGEPGEICVRGPLNCGGYWKLPEQTAELFRHGWLHTGDIARRDAEGFLYIVDRKKDMVISGGFNIFPREVEDVLATHPAVAAAAVIGVPDEKWGEAVKAVVVRRPGVTTPEDELTGELTALVRDRKGSHHAPKTIDYADSIPVSPLGKPDKKALRARYWSDTTRQVN
>NC_014666.1|WP_013423106.1|2365776_2366088_+|antibiotic-biosynthesis-monooxygenase
MPVIVATMIPKADQVDEVRAILVELIPEVHQEPGCKLYSLHEAPGKFVFVEEWADDAAMAAHGAGPAIGKMFSALDGRLDGPPDLVFLTPVPAGDPALGQLRA

Crispr_ID: NC_014666_7

• CRISPR_ID: NC_014666_7
• CRISPR_location: 2381469-2381610
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_014666_7

Consensus_repeat	Method
GGGGGGTCGAGGTTGCTTCGCTTCTCGACGGTCGGCTTGTTCGGC	CRISPRCasFinder

spacers of NC_014666_7

>7.1|2381514|52|NC_014666|CRISPRCasFinder
TGGGGTGGGGTGGGCTGGCCTGTGGCCCGCCGGTGTCGAGCTTCGCTCGATC

CRISPR arrays and Neighbor proteins around NC_014666_7

CRISPR arrays

The CRISPR arrays of NC_014666_7

>merge|NC_014666|7|2381469-2381610|CRISPRCasFinder
GGGGGGTCGAGGTTGCTTCGCTTCTCGACGGTCGGCTTGTTCGGCTGGGGTGGGGTGGGCTGGCCTGTGGCCCGCCGGTGTCGAGCTTCGCTCGATCGGGGGGTCGAGGTTGCTTCGCTTCTCGATGGTCGGCTTGTTCGGC

>NC_014666|7|6|2381469-2381610|CRISPRCasFinder
GGGGGGTCGAGGTTGCTTCGCTTCTCGACGGTCGGCTTGTTCGGC	TGGGGTGGGGTGGGCTGGCCTGTGGCCCGCCGGTGTCGAGCTTCGCTCGATC
GGGGGGTCGAGGTTGCTTCGCTTCTCGATGGTCGGCTTGTTCGGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_014666.1|WP_083819464.1|2379551_2380388_-|4'-phosphopantetheinyl-transferase-superfamily-protein	unknown	unknown	gnl|CDD|225524
NC_014666.1|WP_157735359.1|2371343_2372201_-|L,D-transpeptidase-family-protein	unknown	unknown	gnl|CDD|341130
NC_014666.1|WP_013423125.1|2389633_2390050_+|nucleoside-diphosphate-kinase	unknown	unknown	gnl|CDD|179085
NC_014666.1|WP_095522693.1|2388180_2389440_+|bifunctional-folylpolyglutamate-synthase/dihydrofolate-synthase	unknown	unknown	gnl|CDD|223362
NC_014666.1|WP_013423112.1|2371013_2371217_+|hypothetical-protein	unknown	unknown	unknown
NC_014666.1|WP_013423110.1|2368874_2369795_-|dihydroorotate-oxidase	unknown	unknown	gnl|CDD|240092
NC_014666.1|WP_013423109.1|2367446_2368805_-|stress-protein	unknown	unknown	gnl|CDD|378410
NC_014666.1|WP_013423119.1|2381971_2383390_+|trigger-factor	unknown	unknown	gnl|CDD|234956
NC_014666.1|WP_013423121.1|2384454_2385087_+|ATP-dependent-Clp-protease-proteolytic-subunit	unknown	unknown	gnl|CDD|178955
NC_014666.1|WP_157735361.1|2377650_2379555_-|methyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|372616
NC_014666.1|WP_013423116.1|2375696_2377577_-|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|372616
NC_014666.1|WP_157735360.1|2372510_2375084_-|S1-RNA-binding-domain-containing-protein	unknown	unknown	gnl|CDD|225094
NC_014666.1|WP_013423126.1|2390731_2391763_+|rod-shape-determining-protein	unknown	unknown	gnl|CDD|237562
NC_014666.1|WP_013423115.1|2375350_2375614_-|hypothetical-protein	unknown	unknown	unknown
NC_014666.1|WP_013423122.1|2385382_2386675_+|ATP-dependent-Clp-protease-ATP-binding-subunit-ClpX	unknown	unknown	gnl|CDD|235422
NC_014666.1|WP_071587938.1|2369958_2370813_-|metalloprotease	unknown	unknown	gnl|CDD|225203
NC_014666.1|WP_013423128.1|2393068_2393617_+|rod-shape-determining-protein-MreD	unknown	unknown	gnl|CDD|274574
NC_014666.1|WP_049806864.1|2392101_2393064_+|rod-shape-determining-protein-MreC	unknown	unknown	gnl|CDD|237560
NC_014666.1|WP_013423120.1|2383745_2384393_+|ATP-dependent-Clp-protease-proteolytic-subunit	unknown	unknown	gnl|CDD|178955
NC_014666.1|WP_013423123.1|2387078_2387879_-|thioesterase-family-protein	unknown	unknown	gnl|CDD|379298

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_014666.1|WP_083819464.1|2379551_2380388_-|4'-phosphopantetheinyl-transferase-superfamily-protein	gnl|CDD|225524	COG2977, EntD, Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism].	3.64813e-54
NC_014666.1|WP_157735359.1|2371343_2372201_-|L,D-transpeptidase-family-protein	gnl|CDD|341130	cd16913, YkuD_like, L,D-transpeptidases/carboxypeptidases similar to Bacillus YkuD. Members of the YkuD-like family of proteins are found in a range of bacteria. The best studied member Bacillus YkuD has been shown to act as an L,D-transpeptidase that gives rise to an alternative pathway for peptidoglycan cross-linking. Another member Helicobacter pylori Csd6 functions as an L,D-carboxypeptidase and regulates helical cell shape and motility. The conserved region contains a conserved histidine and cysteine, with the cysteine thought to be an active site residue.	2.51534e-31
NC_014666.1|WP_013423125.1|2389633_2390050_+|nucleoside-diphosphate-kinase	gnl|CDD|179085	PRK00668, ndk, mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated.	6.67978e-83
NC_014666.1|WP_013423123.1|2387078_2387879_-|thioesterase-family-protein	gnl|CDD|379298	pfam13622, 4HBT_3, Thioesterase-like superfamily. This family contains a wide variety of enzymes, principally thioesterases. These enzymes are part of the Hotdog fold superfamily.	5.61347e-51
NC_014666.1|WP_013423110.1|2368874_2369795_-|dihydroorotate-oxidase	gnl|CDD|240092	cd04741, DHOD_1A_like, Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires FMN as co-factor. DHOD divides into class 1 and class 2 based on their amino acid sequences and cellular location. Members of class 1 are cytosolic enzymes and multimers while class 2 enzymes are membrane associated and monomeric. The class 1 enzymes can be further divided into subtypes 1A and 1B which are homodimers and heterotetrameric proteins, respectively.	1.14443e-88
NC_014666.1|WP_013423109.1|2367446_2368805_-|stress-protein	gnl|CDD|378410	pfam10138, vWA-TerF-like, vWA found in TerF C-terminus. vWA domain fused to TerD domain typified by the TerF protein. Some times found as solos.	1.7281e-90
NC_014666.1|WP_013423119.1|2381971_2383390_+|trigger-factor	gnl|CDD|234956	PRK01490, tig, trigger factor; Provisional.	9.28647e-144
NC_014666.1|WP_013423121.1|2384454_2385087_+|ATP-dependent-Clp-protease-proteolytic-subunit	gnl|CDD|178955	PRK00277, clpP, ATP-dependent Clp protease proteolytic subunit; Reviewed.	3.37238e-124
NC_014666.1|WP_157735361.1|2377650_2379555_-|methyltransferase-domain-containing-protein	gnl|CDD|372616	pfam13489, Methyltransf_23, Methyltransferase domain. This family appears to be a methyltransferase domain.	7.06494e-27
NC_014666.1|WP_013423116.1|2375696_2377577_-|class-I-SAM-dependent-methyltransferase	gnl|CDD|372616	pfam13489, Methyltransf_23, Methyltransferase domain. This family appears to be a methyltransferase domain.	7.5093e-25
NC_014666.1|WP_157735360.1|2372510_2375084_-|S1-RNA-binding-domain-containing-protein	gnl|CDD|225094	COG2183, Tex, Transcriptional accessory protein [Transcription].	0
NC_014666.1|WP_013423126.1|2390731_2391763_+|rod-shape-determining-protein	gnl|CDD|237562	PRK13927, PRK13927, rod shape-determining protein MreB; Provisional.	0
NC_014666.1|WP_095522693.1|2388180_2389440_+|bifunctional-folylpolyglutamate-synthase/dihydrofolate-synthase	gnl|CDD|223362	COG0285, FolC, Folylpolyglutamate synthase [Coenzyme metabolism].	3.75039e-127
NC_014666.1|WP_013423122.1|2385382_2386675_+|ATP-dependent-Clp-protease-ATP-binding-subunit-ClpX	gnl|CDD|235422	PRK05342, clpX, ATP-dependent Clp protease ATP-binding subunit ClpX.	0
NC_014666.1|WP_071587938.1|2369958_2370813_-|metalloprotease	gnl|CDD|225203	COG2321, COG2321, Predicted metalloprotease [General function prediction only].	5.18885e-09
NC_014666.1|WP_013423128.1|2393068_2393617_+|rod-shape-determining-protein-MreD	gnl|CDD|274574	TIGR03426, shape_MreD, rod shape-determining protein MreD. Members of this protein family are the MreD protein of bacterial cell shape determination. Most rod-shaped bacteria depend on MreB and RodA to achieve either a rod shape or some other non-spherical morphology such as coil or stalk formation. MreD is encoded in an operon with MreB, and often with RodA and PBP-2 as well. It is highly hydrophobic (therefore somewhat low-complexity) and highly divergent, and therefore sometimes tricky to discover by homology, but this model finds most examples. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	2.3203e-10
NC_014666.1|WP_049806864.1|2392101_2393064_+|rod-shape-determining-protein-MreC	gnl|CDD|237560	PRK13922, PRK13922, rod shape-determining protein MreC; Provisional.	1.86021e-52
NC_014666.1|WP_013423120.1|2383745_2384393_+|ATP-dependent-Clp-protease-proteolytic-subunit	gnl|CDD|178955	PRK00277, clpP, ATP-dependent Clp protease proteolytic subunit; Reviewed.	1.7554e-118

Protein sequences

>NC_014666.1|WP_083819464.1|2379551_2380388_-|4'-phosphopantetheinyl-transferase-superfamily-protein
MPEVGVGAAASLLADLVPAKAVAAETLVDESPSELFPAEEALLARAVPKRRREFTAGRVCARRAMARLGVAPAPLLAGPNREPLWPAGLVGSITHCEGYRAAVVARAGDVLSIGIDAEPNGPTPDGVFERIALPAESSWVRAVARAEPEVHWDRLLFCAKESVYKAWFPLAGSWLGFEDALITLDGRPADASPAAQGPAAHGPGGSGPDDSGPTGDVERTGAATRRTGTFTAKLLVTGPVLPGGRRLTSMRGRYLVTQGLILAVVAISPEDRVDGDSA
>NC_014666.1|WP_157735361.1|2377650_2379555_-|methyltransferase-domain-containing-protein
MMNRAVLPAALTAGIVINTARLRRRLAALPVIEPSDDRVHHTHVFLAADGVRLDDAQQRAASAYARRHGLDVLDLVPDELSPDRLLDLARLVDPARYRTDRLAPGRGAYQALLIDRDVLARAGLHPKEVTEVGLVAVTATLKRYAPLTTGLAVLPGLRAAPRTGQQRLAVRQATSRWDPARPLGPMVRDLALARGLARAPRWTLAAAAASWLQPVAAASGGPVRLRPAEALTAPLQRRRAAAEFVADASALGAAAARSAQVRTPGEPGGADSGGLARWGFARPHAFPADDAEHAAELRAIYQADLAGGVERFLAAARPTCPWCGGARLTKVTDGFDATLAKPGRFRYDRCADCRHVFQNPSPTDEGLDFYYRDFYDGLGAPIMEVIGDAGRAGYLARARSVPPTPRTWLDVGTGMGHFCLMARDVWPTTVFDGLDQGEALAEGARRGWIDHTYSGQLPDLAPSLAGRYDVVSMFHYLEHTRDPRADLDAAITALSPGGHLLIEVPNPESLSARVYGPLWSGWLAPQHLHLIPADNLVDALTARGLRVEHVEFGRAHLDGDGMYAWWALCQRLAPSLDLPWRAQPGSPGGQARRLATLAALGPLFPAMVVADAAARPYLTGGRRSNAYRVLARLP
>NC_014666.1|WP_013423116.1|2375696_2377577_-|class-I-SAM-dependent-methyltransferase
MNRRTWISAAVAAGVGLNTARLRRRLSALPVIGPSDEPVHHAHVFLTVGGVRLDEAQRRAASAHARRHGLDVLDLVPEQLTPDRLLDLARLVDTTSYQANRLTPGRGAYQALLVDREILARSALDPKDLGETDLVAITAVLKRHAPTTTALAVLPGLRALPRTGAERFAVQRAAYAWQPPSLVAPAVRDALLATGARAAPGWTLAAAALSWLQPAAVAAGGPVRIDRADLLAAPLVRRRGAAELVADLAPTRATERLGRWRVSLPPAYAADDEAGLEAARAAYRADLAAGVERFLEEPRTTCPWCGGPRLRRMTVGVDTMQVKPGRFRYDRCADCRHVFQNPRLTPEGLDFYYRDFYGGLGRDSMEQVLGFGPGSHPARARSVPPTPRTWLDVGAGHGHFCLLARDVWPSTVFDGLDLGDGIEEAGRRGWVENAYLGQFPDLAPSLAGRYDVVSMFHYLEHTGDPRAELDAAALALRPGGHLLIEVPNPDSVTFRAYGPLASGMLIPQHLNLLPADNLVDALTARGFVIEHVEFGQVHISGDAPLAWWGVFQLLGPSPDLPWRDVRRPLLGYARRAAAFAALAPLMPVAAVAEAASRPFLTRGNRANAYRILARLADPGAATSAIG
>NC_014666.1|WP_013423115.1|2375350_2375614_-|hypothetical-protein
MSVCEVCGNDYAMSFEVHAQGAVHVFDSFECAIHAMSPVCEHCGVKISGHGVEADGRFYCCAHCARGEGVDSSLIRDHADTGRLAQA
>NC_014666.1|WP_157735360.1|2372510_2375084_-|S1-RNA-binding-domain-containing-protein
MEGRIADELGVRENQVVAAVGLLDGGSTVPFIARYRKEVTGTLDDTQLRTLEERLRYLRELEERRAAILESIRSQGKLDDALEAQINAADSKARLEDIYLPYKPKRRTKAQIAREAGLEPLADALLGDPTLDPTTTAAGYADAEKGVADAAAALDGARAILVERFAEDADLIGELRERMWGRGRVVSKVREGKEEAGAKFSDYFAFDEPFTSLPSHRVLALLRGEKEEILDLDLDPEPEDADPTAPVVPSGYETAIAARFGVTDAGRPADRWLGDTVRWAWRTRVLVHLGIDLRLRLFQAAEDEAVRVFATNLRDLLLAAPAGTRATMGLDPGYRTGVKVAVVDATGKCVATDTIYPHVPARRWDEALVKLHKLCAAHQVELIAIGNGTASRETDKLAEELVRAASELKLTKIVVSEAGASVYSASAFASKELPGMDVSLRGAVSIARRLQDPLAELVKIDPKSIGVGQYQHDLSELKLSRSLDAVVEDAVNAVGVDVNTASTPLLTRVSGIGATLAENIVAHRDAKGPFRTRTALREVPRLGPKAFEQCAGFLRIPDGDDPLDASSVHPESYPVVRRILTATNGDIRGLIGNSTALRAVKATDFVDETFGLPTVTDILAELEKPGRDPRPAFKTATFADGVDEISDLVAGMVLEGVVTNVAAFGAFVDVGVHQDGLVHVSAMSKTFVRDPREVAKPGDIVKVKVLDVDVPRKRISLTLRLDDDAATGGGGGGGGGREGRAQRSGPRGGGQAAGGQPGGGRPGSQSGGSQNGGGAGQAGGRDGGRDARGADNRGPRRDAGTRGAPADGRGGGGQRGGTSRGNGQRGGRPAAPPNGAIADALRRAGLVDENGRPRTGK
>NC_014666.1|WP_157735359.1|2371343_2372201_-|L,D-transpeptidase-family-protein
MAVTVAAGLALAGCGGGHSPVAGPKPSVSASPTRPVAKPRAAGLDPAHLPAGWSLVAWPAAGTIPVFGQSAPVTNADAPTSQPSTSEPPARQPPATQAPAVAPVGRSAEQPTSTLANPNAEGAPLVLLVKHYQPDWLQVSLPVRPNGSTGWIRTKDTRLTATPFALTVDKTRHELTVFKDGKPSGVYPVGIGTGTTPTPLGHFYLAELLKPANPAGPWGPYAFGLSGFSDVITNFDGGNGIIGLHGTNQPDRVGTDVSMGCIRLRNSDITALAALLPVGTPVTIT
>NC_014666.1|WP_013423112.1|2371013_2371217_+|hypothetical-protein
MADTRVYTRTSLGTIIYLVIGLIITISQGYWHIDRWDGHFTGSLLTAIAATLLWPISLFYTFILTHR
>NC_014666.1|WP_071587938.1|2369958_2370813_-|metalloprotease
MSPSRRGNGARSGTRYGRGVRTKWAAFAAISVSVALSVGMLSGCNPVDSTTTASTTSPASATGQPAAGSDCGGAATTEADALKVITGPIGCPGGVNTYWAQQLGSVWTTPRFVVYRDGQIPDDQCGAQDRNADDFKGNAFYCRLDDTVAYSQDFMARLYQQGGPSFPMFVLMHELGHRVSRLTNRVGVVSRSEENQADCLAGTEAKFSHDAKRLPGVDVAKGSVLFFSLGDSWFHKESPSDPDAHGTPDQRAAAFLTGYRHDTAKCFAIGQSASGSVPLTGVLG
>NC_014666.1|WP_013423110.1|2368874_2369795_-|dihydroorotate-oxidase
MPLLCGIDLEHPVMNAAGTCKSLDDVQDLARSAAAAIVVGSITVAARTGNSGATYHAGDGFSLNALGLPNRGLAYYVEQLPAMARAAHDAGKPLILSVAGFSVDDYARSAAAAAPTGVDLLELNLACPNVWDGGTQKRIACFDEGQTAAVLAAVDAVLRDAPTRVPYGVKISPFSDPEALAGLAAVLASAVAAGGGPRYVCASNTFPNGLAFDDAGRPVIGVELAGLAGPALRPVALGQVRQLRRLLPASVEIVGAGGVTTGRDVADFLRAGANAVQVATAYWNRDGDPAVFGVIAAEWAEALADA
>NC_014666.1|WP_013423109.1|2367446_2368805_-|stress-protein
MELTKGANTALPDRPVEITVGWRTAGAAGSRTSLDVCALRLGATGKVREDADMVFFNAPSSPDGTVRHIGRSPGGQAEVVTIDPARQPADVEAIVVTATIDVVTPELTFGGLDVWAAVKDLSTGQEVATFTPPPLGPEKALVVVELYRRAGSWKVRAVGQGYASGLAGLATDYGVDVGGDEDVSPPAKALDLPSTGDAKIDMRKRLDLRKQAVKVVLSKQGLTGKQARVGLALDASGSMRPLYKRGTVGRVVERIAAVAATMDDDGTLDVWSYATETLALPPLRVDYLADWIPLYVRQRKATTGQGGAEATLAREEAARAAGWPIPNWDGIGGQNEEQKVIAAIIDHFGRAPSPPPALVLVLTDGGLYRDRMIADLLRQASKLPIFWQFVGVGKAQYGILEKLDTLSGRVVDNAGFFAVDDLDEIDDAALYQRLLSEFPVWLQAARAAGIPV
>NC_014666.1|WP_013423119.1|2381971_2383390_+|trigger-factor
MKATKESLSPTRVKLTVEVPFDDLKPSLDATYKKLSRQIRVSGFRPGKVPPRILDQRLGRSTILDEALQEALPQFYSEAVEAEDVDVLSRPEVDVTEFAEGSPIVFTAEVDVRPQLALPEADSVKITVDKIEVTDEQIDTQLGSMRERFAVLTPVERPVATGDYVSLDLSATVDGEPVEDATATGMSYEVGSGNLIEGIDEALIGASEGDSRTFDTELLAGDRQGQTAQVTAVVRGVKEKELPALDDDFATTASEFDTLDELKADLRQRLEQTRKYEQVNQAREKLLEQLIESVDVPVPDSVLESEIEAREHRLGHDLERYGVDRETYLKTLEQEPEEFDAQVRESATKAIKSQFILDTVVRAESVGIDQGELMEQIVMLAQRSGVAPEQYAQQLAGGNGAGLTALMSDIMRNKALLHLLRQATVVDDDDNAVTLELPERPDPADLEAFEDDGHDHDHDHDHEGHDHEGHDH
>NC_014666.1|WP_013423120.1|2383745_2384393_+|ATP-dependent-Clp-protease-proteolytic-subunit
MSEFAVPSLAAPGGPSLRSAGQSGPGFDEQVYNRLLRERIIFLGTVVEDSIANAICAQLLLLNAEDPNRDIWLYINSPGGSVSAGMAIYDTMQFVENDVATVSLGLAASMGQFLLCAGAAGKRYSLPHARIMMHQPSGGIGGTASDIAIQAEQMLYTKRMMQERIAFHTGQPIDQIERDSDRDRWFTAEEAKDYGFVDHVVQRVRQVPGGTPSGQ
>NC_014666.1|WP_013423121.1|2384454_2385087_+|ATP-dependent-Clp-protease-proteolytic-subunit
MSRYEQTGRYVLPNIIEKTSRGEYGMDPYSKLLKERIVFLGVQIDDVSANDVMAQLLFLESEDPDRDISIYINSPGGSFTSLTAIYDTMQFVRPDIQTICMGQAASAAAVLLAAGTPGKRFALQNSRILIHQPSGSGEGQSSDIEIQAREILRMRSLLEKMLADHTGKAEEDIRRDIERDKILSADEAKEYGLIDEVIKTRKSSRLSAAR
>NC_014666.1|WP_013423122.1|2385382_2386675_+|ATP-dependent-Clp-protease-ATP-binding-subunit-ClpX
MARIGDGGDLLKCSFCGKSQKQVKKLIAGPGVYICDECIDLCNEIIEEELSESSELKWDELPKPREIYEFLDGYVVGQETAKKTLSVAVYNHYKRIQAGGSAPSDSAKADVELAKSNILLLGPTGCGKTLLAQTLARMLNVPFAIADATALTEAGYVGEDVENILLKLIQAADYDVKKAETGIIYIDEVDKIARKSENPSITRDVSGEGVQQALLKILEGTTASVPPQGGRKHPHQEFIQIDTTNVLFIVGGAFAGLDRIIESRIGKKSLGFRAVLHGKDDPDAADVFGDVMPEDLLKYGMIPEFIGRLPVLTSVQNLDREALIRILTEPKNALVRQYKRLFELDNVDLDFTSDALEAIADQAILRGTGARGLRAIMEEVLMSVMYDIPSRKDVARVVVTREVVLEHVNPTLVPRDISAAKRNTRQEKSA
>NC_014666.1|WP_013423123.1|2387078_2387879_-|thioesterase-family-protein
MGDFEKATAATVDESGRWTAEVAPGWDIGGHPHGGYLLALAARIALGVTGRDHPLSITAHFLRSPANAPVTATPTMLRAGRSTAVAAVDLCQADQPIMATLTTTGRAPAESVPVFQRESAPTLPAPEDCVDVASPDNPFRQNLHDKVDVRLDPATVGWAYGQPRGAAEIRGWVRPRDGSEPDALFLLLAADALPPTTFDFGLFGWVPTVELTALLRGTPAPGWLRVVQRSQLIDDGWLDEDVEVWDSADRLVAQARQLAGYRAPKP
>NC_014666.1|WP_095522693.1|2388180_2389440_+|bifunctional-folylpolyglutamate-synthase/dihydrofolate-synthase
MIPDLDRIRDLVDLLGHPERAFPVIHLTGTNGKTSTARMIDSLLGGFGLRSGRYTSPHLESVTERISIDGRPVGAEVFARAYDDVAPYVELVDGRHAERVTFFELLTAMAFSAFADAPVDVGVIEVGLGGTWDATNVVDSLVQVVTPISLDHRELGSTVEEIATEKAGILRPEAVAVLGQQPLGAARVLAARAEELGTTLVREGLEFGVARRKVAVGGQLLTLRGLAGDYDEIFLPLHGEHQAHNAACALVAVEAFLGGGANPLDLELVRAGFASASSPGRLEVVRRSPTIVLDGAHNVAGTQALVAALADGFQFDTLVGVVGVLADKDAHAMLSVLEPAFDSIVLTQSSSPRARSADELGAVAVEVFGADRVEVAPRLDDAIDAAVRLVEEGAELGGGGVVVTGSLTIVGEARHLLAH
>NC_014666.1|WP_013423125.1|2389633_2390050_+|nucleoside-diphosphate-kinase
MSAERTLVLVKPDGVSRGLVGEVISRLERKGLTLVAAELRTLEKATAETHYGEHASKPFFGELVEFITSGPLVALVVEGPRAIEGTRGLMGVTDPVKAVPGSIRGDYALEIGQNLVHGSDSPESAAREIDLFFPGLKG
>NC_014666.1|WP_013423126.1|2390731_2391763_+|rod-shape-determining-protein
MSSSLSFLGRDMAVDLGTANTLVYVRGRGIVLNEPSVVAINTTTTGILAVGTDAKRMIGRTPGNVVAVRPLKDGVIADFETTERMLRYFIQKVHRRRHFAKPRLVVCVPSGITGVEQRAVKDAGYEAGARRVYIIEEPMAAAIGAGLPVHEPTGNMVVDIGGGTTEVAVISLGGIVTSQSIRIAGDELDTAIISYVKKEYSLMLGERTSEEIKMAIGSAYKLPDEPSAEIRGRDLVTGLPKTIVVTAEEIRKAIEEPVNSIIDAVKVTLDRCPPELAGDVMDRGIVLTGGGALLRGLDERLRNETGMPIHIADNPLHSVAMGSGKCVEEFEALQQVLISEPRR
>NC_014666.1|WP_049806864.1|2392101_2393064_+|rod-shape-determining-protein-MreC
MGRDLRRSRVVVAVLLVLTFLLITIDYRTGESSGGPRGFLHGVVGGVEGGVTAVTRPVGRTLSSLAHPNRYHDRADRLEQQNAALRRQLADQGAVTQLAGQLSALRLLADKGQYTIVPARVVAIGDVSGTDWTVTVNAGRADGLAVDKIVINSSGLVGTVVSMTEHTAVVRLFCDPRSRIGARLEGTQLLGAVAGGSGPDKLVFTLYDASYQVKPGQRLVTFGSLDYVAGVPIGEVTKVTEVSGLSRTAEVKPFVSVGSLDLVGIVVGKPATDPGDRVLPPRAVPATQAPAAPQAAGPPNGAPTANPSAPSAAGTPAGAR
>NC_014666.1|WP_013423128.1|2393068_2393617_+|rod-shape-determining-protein-MreD
MTVQLWEPESDADTIHPPTFAAVTFVLLVAVIAQVSVIARLPLPGGGPDLVLMLLATAALVLGPVNGAVLGFVTGLFGDLLSTHVLGQTTLVFLLVGYLVGLVADATERSAVIALAAVSGAVAVGIVADVAVAALLGADGLSSPGHTVVRALAAALYAALLTPFLFPVFTAGVRRTKRVGRR

Crispr_ID: NC_014666_8

• CRISPR_ID: NC_014666_8
• CRISPR_location: 2606850-2607022
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NC_014666_8

Consensus_repeat	Method
TCCCAGACCTACGGCTACGACCAG	PILER-CR

spacers of NC_014666_8

>8.1|2606874|51|NC_014666|PILER-CR
CTCGGCCGCACCACCTCCGACACCCTCACCGCACCCGGCGGGACGCTGCGT
>8.2|2606949|57|NC_014666|PILER-CR
AACAACGACAACCTGACCGCGACGACGATTGCGCCCGCCGGAGTCGCCGGCGCCGGC

CRISPR arrays and Neighbor proteins around NC_014666_8

CRISPR arrays

The CRISPR arrays of NC_014666_8

>merge|NC_014666|8|2606850-2607022|PILER-CR
AGAGCTACGGCTACGACCAGCTCGGCCGCACCACCTCCGACACCCTCACCGCACCCGGCGGGACGCTGCGTTCGCAGACCTACGGCTACGACAACAACGACAACCTGACCGCGACGACGATTGCGCCCGCCGGAGTCGCCGGCGCCGGCTCCCAGTCCTACGGCTACGACCAG

>NC_014666|8|3|2606850-2607022|PILER-CR
AGAGCTACGGCTACGACCAGCTCG	GCCGCACCACCTCCGACACCCTCACCGCACCCGGCGGGACGCTGCGTTCGC
AGACCTACGGCTACGACAACAACG	ACAACCTGACCGCGACGACGATTGCGCCCGCCGGAGTCGCCGGCGCCGGCTCCCAGT
CCTACGGCTACGACCAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_014666.1|WP_157734894.1|2613706_2614945_+|NAD(P)H-binding-protein	unknown	unknown	gnl|CDD|225807
NC_014666.1|WP_157734893.1|2610070_2610322_+|hypothetical-protein	unknown	unknown	gnl|CDD|173847
NC_014666.1|WP_013423297.1|2617798_2619163_-|methylated-DNA-(protein)-cysteine-S-methyltransferase-DNA-binding-protein	unknown	unknown	gnl|CDD|235264
NC_014666.1|WP_013423295.1|2615324_2616110_+|phosphatase-PAP2-family-protein	unknown	unknown	gnl|CDD|379588
NC_014666.1|WP_013423285.1|2588114_2589230_-|DUF58-domain-containing-protein	unknown	unknown	gnl|CDD|224635
NC_014666.1|WP_049806872.1|2619215_2620217_-|aminoglycoside-phosphotransferase-family-protein	unknown	unknown	gnl|CDD|366736
NC_014666.1|WP_013423296.1|2616204_2617338_+|pentapeptide-repeat-containing-protein	unknown	unknown	gnl|CDD|224276
NC_014666.1|WP_013423286.1|2589226_2590231_-|AAA-domain-containing-protein	unknown	unknown	gnl|CDD|285027
NC_014666.1|WP_013423290.1|2596733_2598479_-|lytic-transglycosylase-domain-containing-protein	unknown	unknown	gnl|CDD|225501
NC_014666.1|WP_157734890.1|2583917_2585678_-|hypothetical-protein	unknown	unknown	gnl|CDD|237862
NC_014666.1|WP_013423292.1|2610710_2612147_+|FAD-binding-oxidoreductase	unknown	unknown	gnl|CDD|223354
NC_014666.1|WP_013423289.1|2594826_2596149_+|hypothetical-protein	unknown	unknown	unknown
NC_014666.1|WP_157734892.1|2609281_2609926_+|hypothetical-protein	unknown	unknown	gnl|CDD|336138
NC_014666.1|WP_157734895.1|2617354_2617708_-|hypothetical-protein	unknown	unknown	unknown
NC_014666.1|WP_013423287.1|2590546_2592475_-|toll/interleukin-1-receptor-domain-containing-protein	unknown	unknown	gnl|CDD|379328
NC_014666.1|WP_013423282.1|2582844_2583921_-|cell-envelope-related-transcriptional-attenuator	unknown	unknown	gnl|CDD|367673
NC_014666.1|WP_013423284.1|2585692_2588071_-|transglutaminase-domain-containing-protein	unknown	unknown	gnl|CDD|376628
NC_014666.1|WP_013423288.1|2593182_2593554_+|hypothetical-protein	unknown	unknown	unknown
NC_014666.1|WP_013423293.1|2612402_2613524_+|hypothetical-protein	unknown	unknown	gnl|CDD|368286
NC_014666.1|WP_157734891.1|2592810_2593056_+|hypothetical-protein	unknown	unknown	gnl|CDD|173847

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_014666.1|WP_157734894.1|2613706_2614945_+|NAD(P)H-binding-protein	gnl|CDD|225807	COG3268, COG3268, Uncharacterized conserved protein [Function unknown].	8.716e-29
NC_014666.1|WP_157734893.1|2610070_2610322_+|hypothetical-protein	gnl|CDD|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	6.85012e-09
NC_014666.1|WP_013423297.1|2617798_2619163_-|methylated-DNA-(protein)-cysteine-S-methyltransferase-DNA-binding-protein	gnl|CDD|235264	PRK04247, PRK04247, endonuclease NucS.	3.87587e-05
NC_014666.1|WP_013423295.1|2615324_2616110_+|phosphatase-PAP2-family-protein	gnl|CDD|379588	pfam14378, PAP2_3, PAP2 superfamily.	4.16415e-34
NC_014666.1|WP_013423285.1|2588114_2589230_-|DUF58-domain-containing-protein	gnl|CDD|224635	COG1721, COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only].	8.38681e-25
NC_014666.1|WP_049806872.1|2619215_2620217_-|aminoglycoside-phosphotransferase-family-protein	gnl|CDD|366736	pfam01636, APH, Phosphotransferase enzyme family. This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.	3.5367e-14
NC_014666.1|WP_013423286.1|2589226_2590231_-|AAA-domain-containing-protein	gnl|CDD|285027	pfam07726, AAA_3, ATPase family associated with various cellular activities (AAA). This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.	2.13071e-76
NC_014666.1|WP_013423290.1|2596733_2598479_-|lytic-transglycosylase-domain-containing-protein	gnl|CDD|225501	COG2951, MltB, Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane].	4.2567e-22
NC_014666.1|WP_157734890.1|2583917_2585678_-|hypothetical-protein	gnl|CDD|237862	PRK14948, PRK14948, DNA polymerase III subunit gamma/tau.	1.55963e-05
NC_014666.1|WP_013423292.1|2610710_2612147_+|FAD-binding-oxidoreductase	gnl|CDD|223354	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion].	6.35714e-40
NC_014666.1|WP_013423296.1|2616204_2617338_+|pentapeptide-repeat-containing-protein	gnl|CDD|224276	COG1357, COG1357, Pentapeptide repeats containing protein [Function unknown].	5.19979e-27
NC_014666.1|WP_013423282.1|2582844_2583921_-|cell-envelope-related-transcriptional-attenuator	gnl|CDD|367673	pfam03816, LytR_cpsA_psr, Cell envelope-related transcriptional attenuator domain.	3.64988e-29
NC_014666.1|WP_157734892.1|2609281_2609926_+|hypothetical-protein	gnl|CDD|336138	pfam05536, Neurochondrin, Neurochondrin. This family contains several eukaryotic neurochondrin proteins. Neurochondrin induces hydroxyapatite resorptive activity in bone marrow cells resistant to bafilomycin A1, an inhibitor of macrophage- and osteoclast-mediated resorption. Expression of the gene is localized to chondrocyte, osteoblast, and osteocyte in the bone and to the hippocampus and Purkinje cell layer of cerebellum in the brain.	0.00740329
NC_014666.1|WP_013423287.1|2590546_2592475_-|toll/interleukin-1-receptor-domain-containing-protein	gnl|CDD|379328	pfam13676, TIR_2, TIR domain. This is a family of bacterial Toll-like receptors.	4.68441e-16
NC_014666.1|WP_013423284.1|2585692_2588071_-|transglutaminase-domain-containing-protein	gnl|CDD|376628	pfam01841, Transglut_core, Transglutaminase-like superfamily. This family includes animal transglutaminases and other bacterial proteins of unknown function. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that form the catalytic triad in the structurally characterized transglutaminase, the human blood clotting factor XIIIa'. On the basis of the experimentally demonstrated activity of the Methanobacterium phage pseudomurein endoisopeptidase, it is proposed that many, if not all, microbial homologs of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease.	1.90227e-19
NC_014666.1|WP_013423293.1|2612402_2613524_+|hypothetical-protein	gnl|CDD|368286	pfam05104, Rib_recp_KP_reg, Ribosome receptor lysine/proline rich region. This highly conserved region is found towards the C-terminus of the transmembrane domain. The function is unclear.	0.000476254
NC_014666.1|WP_157734891.1|2592810_2593056_+|hypothetical-protein	gnl|CDD|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	1.16787e-08

Protein sequences

>NC_014666.1|WP_013423290.1|2596733_2598479_-|lytic-transglycosylase-domain-containing-protein
MTNVRRRSRPTSELSATTAPETTSSPEAELADAQTRGDPRPIRDHAPLTDTLVAGPDDLPSDNTPPHPAKPPPPADPAAAHNRRRKTKKKTGRHVSPNSSGKPPGRHRKPLTPSKKRTIRRAQIIGLPTLGLPAIALLLIFTVAPSGNDAAATSRTTPPTTATNYPMPSLNPSGPATGEDDQPPTGALATAAAAPANAPSDLVTLTTADRRIPAPVLAAYQQAATALAGELPGCHLRWQLLAGIGKVESGNATGRQISPNGTVSPTILGPRLTGGGGFARILDTDHGALDGDTIFDRAVGPLQFLPSTWSGAGRDGNADGRKDPNNIHDAALTASGYLCAHHRDLTNPAQLSAAIRAYNPSDAYVRAVLAWTTGYTTTPPTPITPPTAATGPTEGDAQTSEASPYPVFALTPIGTAPATSAASPTAAACNTLTITTGSLTATLTTTTLNLTGRYTTPTGTDPDGTITLHTLARNPTGQTLADTDRPLPLKPSDALPVLLTQLRLDQLTDPGHTTTITLTLTTTPPGCPTQTLTTLTITNITRPAATIPAATNTPTPTTSPTPTASPTPSPSPRPTVTPTAL
>NC_014666.1|WP_013423289.1|2594826_2596149_+|hypothetical-protein
MLTAMTVEAEDIAPDWRYASYRSVRGALQRGQGSAVAWLRDHPDDAQLVYECTSRDTRWDWQVDDRRTYLARLLRDLRLDLAPLITQQRACGPYRSWPDRDPTDEYNQFDLTVGTLETLARTGNTQAREALRGYVRDGARWVDALETISYEWPAEWWDDLWETAAARLGVETPPNLWAAGEPWERWRGRDSHFDRLLDATLPTRHDYPATQNDLAVASDADLVTLLRTPHTDRGTVAAVLRQIRRRGKPVPELLDLVEHLAPLGSSTLVRALHPLGRLVAPPARTWAADPTHPLFRYAPDLLADHGDEQDIPTLLTALDGLADQWCGWDQLTAGIARILSGLPPTAHGEIRTQLVRRLRSLTDASPHSYERASYLRSLLLLDQPDTMNTLAIYLLDCEPEVRRIAAENAPLTSEARRWLTELRDDPIEDHDVKHTAARRL
>NC_014666.1|WP_013423288.1|2593182_2593554_+|hypothetical-protein
MITAAAHRLGALTAVVIGTAARRASHLRAHLLQAADRGEQAAPPDSAGPAVALRIAQALDRLAPARATAARLGARHADSHHHLAAPDEITPLRDAAGGPFDQSLERLRLAAHTLAQPPNRPAL
>NC_014666.1|WP_157734891.1|2592810_2593056_+|hypothetical-protein
MPVTLYRAPDECRAHATPPFRSPGTKCEPWTGRGFAREHRPWTASVPRSQRCRSTSAKITRIYEGTNQIQRIVMSRQLLKG
>NC_014666.1|WP_013423287.1|2590546_2592475_-|toll/interleukin-1-receptor-domain-containing-protein
MALDRDHDNGGRDFYISYVAADKEWASWVAWVILQEGNSVEFGEWYPAGTQLPAKRSEGIERASWIIAIVSEEYQLDDFELMVPRNVIQRDPRGHTTKLIPIRVEDCALRRDLQSFVPIDLFGLDKETAILHLHDQIANARRGTSQPVRSPPFPGPASTADDPAADLSPDLSTEPSFPGHASGLEHEKPLSASRPPPSETPLLPPDQAPSPTPPPLSTPSPVVAPPPARAPSVPATQAPAVGVRAGESAGMVVPIPAHGSAVVPTRPRPPLGPAPAAPTGPFVHQQFRGTPVVPARASGPRRVERAVAPPRASTTIRLDTLATIWPGQVRRRSAICAVTFSPDARMLGVVDDHPSVTMWDIADPSAPQLVLAQPLARRPHTGVAFSSDGLLAAAPAAAGGMVVWGLLAGRWALLERATGREPTGDIESLAFAADSDVLVSAGSRGVLVWHVHPSGARDGAVITDPTAIGKQGVGDRVAIDAAGRIVARSARRRREALSRVSLWDVSNLQALVPLRPVDEGEPVTGLAFAGGLLVVGTGDANGAAAHVWRLDDGAPSARRLALLTEGVRPGPLAVRPDGALLAMGRIDVLWELPVGDLPARLREVQRPGGPDVAAMSALAFSPDNRVLAAGTPGGQVILWRIH
>NC_014666.1|WP_013423286.1|2589226_2590231_-|AAA-domain-containing-protein
MSYGTVTRELATRFKQDFDELVGLVSTSFFGSPEIVRMAIVCLAAEGHVLLDGIPGVGKTSLARAMARSAGGTVRRIQFTPDLLPTDITGSDFLDENRALQFRPGPLFSNIVLADEINRASPKTQSALLEAMQERQVTNSGYSYRLPRPFIVMATQNPKEFAGTYDLPEAEIDRFMMRIAISYPDDVSDEAAILGYNIEANEDESTDELQGGHTQLIESMIDTARRVILRPNLRAYIVDILRETRRMSVSKKEGGEGLLRLGVSPRGGVMLARAAQSWAISHGSPFVTDDHIKQVAPFVLTHRMLVDYGVAETGVTARDLLDDVLRTVRSPQHR
>NC_014666.1|WP_013423285.1|2588114_2589230_-|DUF58-domain-containing-protein
MTTTGRVVLLSSLLLGLAAWLLDYPELLVCAVSGIVGMVAACTWWILPAPFEVTRQFADNRVVEGGALRGTIVITNLSRRRRIPRLTIVETVNGQRMTFTSAPIGPGGFGTEHYAIPARRRGPLTFQPVRTECTDPLGLIRFSRSSGPALEMLVHPFLHRIPALDVPGTTDLEGGSPDIAPQAGAELHSLRKYVAGDDPRLIDWRATGRIGYPLIRLNLVPKMPRGIVVLDTAADTYQGDQFEDAVRVAGALGDAALTRGQPVEIWTTERSRCAALPGSAARGKMLDFLARVTTSGAPQTYDVTSPSALTTVIVSGFRTGAPELLPNRSSEIWLIRVGAPREHSSVSRTVRVVDVPDADSFKRFWPGLVRG
>NC_014666.1|WP_013423284.1|2585692_2588071_-|transglutaminase-domain-containing-protein
MTGGLQTQLRQPSPQGPGAAATAAHPDRGTAEQRQPVPRAGQIGPVSGMLQCVLVAGLMGCAARTMAPAFDRPSAQVCLVVVAVLAAAVPLGRRHLSVASAIATGFVATVAVALAIMIGWRWPGGATASPPRALATVWVRLLTTHTPMAPTPDLIVGPAMVIFALTFAGCWLALRSRAALAPVGPCLLALGIALAMAAAPGPHERWPATLFAALSITLIAVRADLGSPIWVRGPAGVAIGVVAAACAWAASLTGIVPGTDRKDPRDLARPPAVQTSARNPLEDVKRQLLQVDPSVSLFTVRLTPTHPPVDRVTVATLGTFDGARWLDTAQLEPYGPTLPTDPSAHPRASATVSGTVTIDQLEGPFLPVIDRPTSVGGVSVAFEPSSATLFTNAWKSGLSYRFTSQVVTPSRTDLAQAVPESGPAVAAYLPSTAAPLPQWVQDLAKSIVARVNTPYSQLARLQSYLSGPHFPYDIGAPPGDSLAIIQQMLTASDPQARSGHSEQHAAAFALLARALGYPTRIAVGYLLERDSAEPNEFHVTSREAHAWPEVDFANIGWVPFEPTDVSKLNLHQPPSPLNRPENGPVPPGVQARPEPPVIRPDLAPYGSDRFIGLSRLQVLLLVALTPVLLLTLLAGGVVAEKKRRRLVRHRRSEASDRIMGAWEEVLDRLDERGLSIEPGDTAADVAAAAREHFRRPTEAWDTSADEADRGWDSLDPLGAIVTSALFHGAEPTAQEAVDAWNLQAEVHRTLVSGEAVADRLRALLSLRPLLPARLRRQQRPVRRPARSLAREA
>NC_014666.1|WP_157734890.1|2583917_2585678_-|hypothetical-protein
MRRPATLAAALCLVLCGVYVAVAARAHPLRPTAVDFPASSAWLGSLLDSHAVLVDGSSAQIVTTVSLGAPSSAVVQAGTDAYFIDARSAAIKAVQGATFTVKDVPGAGSTTTQRDVLVGKSRAYVVDDGTGVVYPLDPATLKPGPSVLPPSTGVSADDSVVDDSDTVWTLDRQTGSVIRIKGANASVERSGPALKSSELVLVGGRAVVATHPGLAARYATGGATTSCPALAGDAKVTLSATASGSILYAASSARGIVVAIDLHTHTCDRARDLGASGDELGRPVQAGSRVFVPDYSKGIVHIVDTGQPGQYGVLDSTKVVPPGVHFDMFARSEYVFFNNPDGPEAGVIRLDGQVHSVEKYLPVGGAGSPTGGQPTQPPTTPTPPTTPPPTTPPPASDAPQDTTDLKIALSDAQPKPGQEVGLAIVHGPGVSVASVDWNLGDGTELSGEHISHQWARPGDYQIYAVMRLGNGDTKVLHVDVVVHGTHGGEGSNRAPEPTETHNPTATPSAPSATPTPSTTPPTQSPAAPPPTLGTEEPAKTLNHPFDANQGQTTDPVSPPPTQPPPPPTTPSPTFCENLFCDPSSNT
>NC_014666.1|WP_013423282.1|2582844_2583921_-|cell-envelope-related-transcriptional-attenuator
MTTSQDGKTGEAAQPGDGWPPPGARTVMRRTARAVLAAFCAVAVALTVAVVGFPTQSRQLVLSALLRHTAIDFGSAPPHGRSPTYVLFVASDRRDTLGSGAAEHVGTLDGQRADSIAILRLLPGGPSALLQIPRDLRAPVPGHGVQKLGAAYSFGTESLLAAVRSVTGIDVDHVVQVDFVVLVAVVDLLGGVDLSFGRPARDLVTGFHANAGTQHLSGAQALAFARSRLYEQYDGTRWVGTNDGDVERINRQAELVRTIFRQIGRIKDPLALLRVLWAVRNHLVVDQDLAGTELARIVTTVAKAHGIKTVQLPSQRAQTDLERLSPFEPLHWGSVSYQVLTQPAATTMLQSFVRGDAS
>NC_014666.1|WP_157734892.1|2609281_2609926_+|hypothetical-protein
MVEELRIVAKVVSDLLVKECEFTKKGNLFLRRDSGLLRTAVVSRSKWSHPGSFGFDVSLNLGIAGLSSSSAARSEWVVSASLNKIHRMRTKSTVGLEISGDPDEDAGTCSELSDVLRSVSSEFLLRSSGPADLIDLVCNGVADFKRLDLWPWNELPRLELACVYLEFIGETQAAAELQTKAGEVAASSGVDYFPSRLQKNIIKAAEMRATALGR
>NC_014666.1|WP_157734893.1|2610070_2610322_+|hypothetical-protein
MAGDVRRPPRGSLCRPARDATLPALGTKCEPWTGCGFAREHRPWTASVPRSQRCRSISAKITQIYEGTNQVQRVVMSRQLLKS
>NC_014666.1|WP_013423292.1|2610710_2612147_+|FAD-binding-oxidoreductase
MSAQVLTLEGERQTLSDETVEEIRAIFRGAVLTADDVGYDEARIIQNAMLDRRPGLIVRCTGTADVVDAVKMATERNLLVAVRGGGHSIAGSCTADDALMIDLSVMRGVWVDPERRRVRVAGGATWGDVDRETQLHGLAVPGGVVSTTGVAGLTLGGGIGWLHRKYGLACDALRAADVVTVRGDIVRCSASEHEDLFWALRGGGGNFGVVVSFEFEAYPLGPVVWNGMVVYPIDAAAEVLPRWRDWTSTVPDEVTSRAMFWTLPAVPPFPPSVHNRDVFMMAALYAGDPDEGRRACRELGEFGRPLADMSQALSYRTAQSALDPLFPKGELQSYWKSVYLDRLDEETTGFVVRVGQDRPSPKTLVHAPLMGGAMSRVGATETAFGDRGARYILSLDGNWLDPADNDVNIRWVRDAYHEAVTLRAASGTYLNFGGDADLDDDDRVRAWGRNVERLRQVKRSYDPENRLRLNPNIPPAEN
>NC_014666.1|WP_013423293.1|2612402_2613524_+|hypothetical-protein
MPASTTALPPGAASALPTSMGPSPSPSVSPSVTRLPGAAASTQPGAAVGGGLVAGNPAGRAAVPAAAAAVDTSHPTRVVGSGTPASCTSAAVVAAVAAGGIITFSCGPNPVIITMTATARVVNAASPQVVIDGGGLVTLNGAGHRRILYLDTCDKAQGWTTSHCDDQETPSLTVQNLTFANGNSTGDTAEGGGGGAILVRGGQFRIVHSAFVTNTCDPAGPDLGGAAIRVLDQYQDRPVYVVNSTFTGGSCSNGGALSSIGVSWTVLNSVFRNNKAIGRGANPASSGTPGGGSGGAIYNDGNQMALRIAGSILENNSAVEGGGAVFFVSNNKTGTLTIENSTLRGNPSAGFETSPGIYFNSSGKPSVSTSTIS
>NC_014666.1|WP_157734894.1|2613706_2614945_+|NAD(P)H-binding-protein
MGPGPGRAAGSDPRCGGESESLPRPGAVPFVGMGGRIVVFGATGYTGRLVTAELVAAGHRPVVAGRDRARVDALRARHDDLPGALADAADPDSVRRLVEPGDVLVATVGPFSRFGRPAVDAAIAAGAHYLDSSGEADFLRQVYEDAGPRAERAGVVLLPASGFDCVPGNLAGALALRDAGEEARRVDVAYQVVPPGGRLHRLGISSGTRATMLASAFSPVEMLRAGRLVTLPFGREVRTFRQDRSVLTGVLWAGTEARTLPRLAPRLTEAATYMVAGGRPARLARAASYPLAALSRLRVFTRLAGVAAAPALRVTGRGPDPAAQDATSTVVLATVADASGRQLATVRLEGVDPYVFTGRIMAWIAGQLASGAVTGHGALGPVEAFGVDGLEPAVAAAGLRRVGLPGVSSGSS
>NC_014666.1|WP_013423295.1|2615324_2616110_+|phosphatase-PAP2-family-protein
MWAWLSFENATASRSRFLTVHLALETLLIIVGFQLYSIIADHAPRHAQQALGRTDRVLRAERAVHLSPELWVNTWWARSHLREAVGNYYYDGPHFIVTALVLTLLLVLRPNQYRLYRDILFVASLLALVVFWLCPVGPPRLLPSAEFVDTVARVRTFGAGGQHGITSAENPFAAMPSLHVGWALWVAMASRALTDNRWLRALAWCYPALTTFVVMATGNHLLADAAAAAILLPLSSALVRVALGARETTFREPARREVASE
>NC_014666.1|WP_013423296.1|2616204_2617338_+|pentapeptide-repeat-containing-protein
MRWITDDFRVGYSQYYLCDYNVIPESVGLNQAFQGNTLVGAGGGHLAVVCGTHYGRIRITVEVRDDEPAAAFDGWAMAVDVSHHSNTGRTWLGDMDTGGPPELGNLTPGGPGWYRVRVRARGRDAARAAGSTGFDADPPIEEHAVSIWPALPAPDLVHRSEDEIAGGPRPAPSGPLPAFYPECRPGWASAPASDEPTELVPQRVEKIIDWTIAHYPGAQLVGALLAGRDLAFADFMAARLTGADLTGSILIKTKLTATDLAGARLSQANLDGADLANANLTGARLDDAILTGVHLSEGRLVDAVLTRANLHRADLVGADLTGADLTGARLDGVRWSDSPDWPETTHWPSPTLARHIRAHSDASPIRPTDFTVRSLTL
>NC_014666.1|WP_157734895.1|2617354_2617708_-|hypothetical-protein
MGTPAYNEELDVLLADAGATGDQLHERLCSTFDGDGALALRAKAKAGEVCYLAVVRKVEQPPPCCLGKLQTNTKARRRLCATRSLNVATECATESKARQSRYRDSPDSPAGACAGGP
>NC_014666.1|WP_013423297.1|2617798_2619163_-|methylated-DNA-(protein)-cysteine-S-methyltransferase-DNA-binding-protein
MTLLFKVNGAKATALPAVSLAEAGLSERADLQEWVLANPAILGDDVMVVTSEYDQWTGSDGLRARDRLDILGLSTAGRLVVVELKRDAAPGDTHLQAINYAAMVSGFTLDTLADAHATWLTRRGNPTDRDSARALLLEHLGGGELDPELLRKPRIMLIAGAFPRQVTNTAVWLSQFDLIVELVEVAAWRSDDGFLAGFNRLWPTTGAEEFTLSPMARADAERVSQKEVQRSRAASAVRRLIDAETLADGTTLRLTLSAVPAAQRAKLDQWIQQEPSRGRAAWQNDPKGPLRWEADGGIWTPTRLVLHILAQATGSAPESVRGPIWWEVEAGHSLADLAEAVPGQSRRDWSDLHACLDALPAGRWTTYGDLAQVVATKAQPLGQHIATCPSCQNRWRVLDADGTVAADFKWPDPSRADTPQQVLESEGITFTNGTADPSVRLSLTDVANLLRRAS
>NC_014666.1|WP_049806872.1|2619215_2620217_-|aminoglycoside-phosphotransferase-family-protein
MAKTSDPDGLYRIALASTDRSAGFYNHNVRIETPAGSVVVRIPIPGADTMDLTIWPEADVVRAIDPVIARVPRLVHSSVEPVYQVVEWIDGDVLDAVAPRGKPVPGHVVGDVGELFAQLGRVPLEQLPALPADWPLDGDTASFANRLSDITASVHARFLGEFGELFDGLGFPADPLGPVLERWQTLSPRPFRLLHTDIHRKNMIVDVDVTYFLDWELALWGDPVYDLAVHLHKMGYQADEEEAAQAAWLAAVPAGAAVEWRADLATYLAHERVKSAVVDSVRYAKLIAAGTEPPDAEAALVDKLTAKVRTAHAVWKSSRAPDHATVEGCVRSR

Crispr_ID: NC_014666_9

• CRISPR_ID: NC_014666_9
• CRISPR_location: 3185057-3185154
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_014666_9

Consensus_repeat	Method
GAGGCGGCACCGTCCAGCGCCCC	CRISPRCasFinder

spacers of NC_014666_9

>9.1|3185080|52|NC_014666|CRISPRCasFinder
CGCCGGCCAGCCTGGCGAGCTGACCGGTCGGTCGGTCGTATCCGGTGGTGCG

CRISPR arrays and Neighbor proteins around NC_014666_9

CRISPR arrays

The CRISPR arrays of NC_014666_9

>merge|NC_014666|9|3185057-3185154|CRISPRCasFinder
GAGGCGGCACCGTCCAGCGCCCCCGCCGGCCAGCCTGGCGAGCTGACCGGTCGGTCGGTCGTATCCGGTGGTGCGGAGGCGGCACCGCCCAGCGCCCC

>NC_014666|9|7|3185057-3185154|CRISPRCasFinder
GAGGCGGCACCGTCCAGCGCCCC	CGCCGGCCAGCCTGGCGAGCTGACCGGTCGGTCGGTCGTATCCGGTGGTGCG
GAGGCGGCACCGCCCAGCGCCCC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_014666.1|WP_013423753.1|3177876_3178878_-|ABC-transporter-permease-subunit	unknown	unknown	gnl|CDD|372253
NC_014666.1|WP_049806886.1|3174075_3175005_-|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl|CDD|223528
NC_014666.1|WP_013423758.1|3183599_3184175_+|DUF302-domain-containing-protein	unknown	unknown	gnl|CDD|269820
NC_014666.1|WP_041260714.1|3190291_3190684_-|glyoxalase	unknown	unknown	gnl|CDD|319901
NC_014666.1|WP_013423756.1|3182346_3183270_+|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223669
NC_014666.1|WP_013423762.1|3187045_3187831_-|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|379312
NC_014666.1|WP_157734919.1|3177308_3177860_+|Rrf2-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224870
NC_014666.1|WP_013423755.1|3181643_3182249_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|132427
NC_014666.1|WP_013423769.1|3196024_3197473_+|MFS-transporter	unknown	unknown	gnl|CDD|129794
NC_014666.1|WP_013423751.1|3176551_3177286_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|223774
NC_014666.1|WP_013423757.1|3183266_3183563_+|hypothetical-protein	unknown	unknown	unknown
NC_014666.1|WP_157735406.1|3188257_3188476_-|hypothetical-protein	unknown	unknown	unknown
NC_014666.1|WP_041260713.1|3185328_3186021_+|aminopeptidase-P-family-protein	unknown	unknown	gnl|CDD|376349
NC_014666.1|WP_013423750.1|3175110_3176448_-|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|224172
NC_014666.1|WP_013423768.1|3194974_3195787_+|amidohydrolase	unknown	unknown	gnl|CDD|225070
NC_014666.1|WP_157735407.1|3192080_3193442_-|cytochrome-P450	unknown	unknown	gnl|CDD|225035
NC_014666.1|WP_013423761.1|3186156_3186993_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|197666
NC_014666.1|WP_041259261.1|3188655_3189972_+|DUF222-domain-containing-protein	unknown	unknown	gnl|CDD|367155
NC_014666.1|WP_041259256.1|3178874_3181466_-|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|213235
NC_014666.1|WP_013423767.1|3193656_3194868_-|cytochrome-P450	unknown	unknown	gnl|CDD|225035

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_014666.1|WP_013423753.1|3177876_3178878_-|ABC-transporter-permease-subunit	gnl|CDD|372253	pfam12679, ABC2_membrane_2, ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family.	2.19212e-12
NC_014666.1|WP_013423751.1|3176551_3177286_-|SDR-family-oxidoreductase	gnl|CDD|223774	COG0702, COG0702, Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism].	3.02298e-14
NC_014666.1|WP_013423758.1|3183599_3184175_+|DUF302-domain-containing-protein	gnl|CDD|269820	cd14797, DUF302, Uncharacterized domain family DUF302. These domains are mostly found in bacterial single-domain proteins and have been shown to form homodimers; they may also bind zinc. Also characterized as COG3439.	1.05128e-11
NC_014666.1|WP_041260714.1|3190291_3190684_-|glyoxalase	gnl|CDD|319901	cd07235, MRD, Mitomycin C resistance protein (MRD). Mitomycin C (MC) is a naturally occurring antibiotic, and antitumor agent used in the treatment of cancer. Its antitumor activity is exerted primarily through monofunctional and bifunctional alkylation of DNA. MRD binds to MC and functions as a component of the MC exporting system. MC is bound to MRD by a stacking interaction between a His and a Trp. MRD adopts a structural fold similar to bleomycin resistance protein, glyoxalase I, and extradiol dioxygenases; and it has binding sites at an identical location to binding sites in these evolutionarily related enzymes.	6.93902e-51
NC_014666.1|WP_013423756.1|3182346_3183270_+|alpha/beta-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.14472e-18
NC_014666.1|WP_013423762.1|3187045_3187831_-|class-I-SAM-dependent-methyltransferase	gnl|CDD|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	3.47567e-17
NC_014666.1|WP_157734919.1|3177308_3177860_+|Rrf2-family-transcriptional-regulator	gnl|CDD|224870	COG1959, COG1959, Predicted transcriptional regulator [Transcription].	2.78857e-34
NC_014666.1|WP_013423755.1|3181643_3182249_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|132427	TIGR03384, betaine_BetI, transcriptional repressor BetI. BetI is a DNA-binding transcriptional repressor of the bet (betaine) regulon. In sequence, it is related to TetR (pfam00440). Choline, through BetI, induces the expression of the betaine biosynthesis genes betA and betB by derepression. The choline porter gene betT is also part of this regulon in Escherichia coli. Note that a different transcriptional regulator, ArcA, controls the expression of bet regulon genes in response to oxygen, as BetA is an oxygen-dependent enzyme. [Regulatory functions, DNA interactions].	4.76005e-09
NC_014666.1|WP_013423769.1|3196024_3197473_+|MFS-transporter	gnl|CDD|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	7.73323e-42
NC_014666.1|WP_013423761.1|3186156_3186993_+|helix-turn-helix-domain-containing-protein	gnl|CDD|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	1.32192e-10
NC_014666.1|WP_049806886.1|3174075_3175005_-|NAD-dependent-epimerase/dehydratase-family-protein	gnl|CDD|223528	COG0451, WcaG, Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism].	2.58364e-25
NC_014666.1|WP_041260713.1|3185328_3186021_+|aminopeptidase-P-family-protein	gnl|CDD|376349	pfam00557, Peptidase_M24, Metallopeptidase family M24. This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.	3.35159e-19
NC_014666.1|WP_013423750.1|3175110_3176448_-|NAD(P)/FAD-dependent-oxidoreductase	gnl|CDD|224172	COG1252, Ndh, NADH dehydrogenase, FAD-containing subunit [Energy production and conversion].	1.04887e-97
NC_014666.1|WP_157735407.1|3192080_3193442_-|cytochrome-P450	gnl|CDD|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	5.58097e-92
NC_014666.1|WP_013423768.1|3194974_3195787_+|amidohydrolase	gnl|CDD|225070	COG2159, COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only].	3.88399e-55
NC_014666.1|WP_041259261.1|3188655_3189972_+|DUF222-domain-containing-protein	gnl|CDD|367155	pfam02720, DUF222, Domain of unknown function (DUF222). This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.	3.95308e-17
NC_014666.1|WP_041259256.1|3178874_3181466_-|alpha/beta-fold-hydrolase	gnl|CDD|213235	cd03268, ABC_BcrA_bacitracin_resist, ATP-binding cassette domain of the bacitracin-resistance transporter. The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multi-enzyme complex BcrABC. Bacitracin has potent antibiotic activity against gram-positive bacteria. The inhibition of peptidoglycan biosynthesis is the best characterized bacterial effect of bacitracin. The bacitracin resistance of B. licheniformis is mediated by the ABC transporter Bcr which is composed of two identical BcrA ATP-binding subunits and one each of the integral membrane proteins, BcrB and BcrC. B. subtilis cells carrying bcr genes on high-copy number plasmids develop collateral detergent sensitivity, a similar phenomenon in human cells with overexpressed multi-drug resistance P-glycoprotein.	4.1392e-84
NC_014666.1|WP_013423767.1|3193656_3194868_-|cytochrome-P450	gnl|CDD|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	1.10752e-80

Protein sequences

>NC_014666.1|WP_013423758.1|3183599_3184175_+|DUF302-domain-containing-protein
MGTGAHGVLSQGGLSEATVVAYEARRLTIVASLGYDVFVARFEAAVPVLELARFEALVDSGRGWDDVLAAADENAPHGFMRFWQADVTAMMSPLGLPWRCVEYLMGNQTIAARMYRHDPAVMLYAPLRVTIHTGLDGAACFGIDRPGAQLGSFTDPRIASVGLELDRKVAQLLDAIGVPAPGELTADDLPA
>NC_014666.1|WP_013423757.1|3183266_3183563_+|hypothetical-protein
MTRPGVCPAGAATVVVFLLYLLVYLLVLLGMLLLGGSLWPSRAVSWWQAALVGVGALLGFAGPEGPSARGSPFRSPSGWLWPPAGSRGRRTAEARTSR
>NC_014666.1|WP_013423756.1|3182346_3183270_+|alpha/beta-hydrolase
MSVAYAHNGSVELAYERIGAPDGEPLLLVTGLGGQLLDWPDGFCAALAAEGFSVIRFDNRDSGLSTHFDDRAAPSHWSSLARGRSRRAPYEGTAFADDAVAVMDAAGWPSAHVVGISMGAAIAQLAAVRHPRRVRSMSLIGCLPPVGVRTLFHLRYGVFVSMARKRFPETREGAGERMVALARALASPGHPFDEEWAREVGLRCHDRRPHDMRAERRQLAAARAARGWKPGRISVPTTVLYGADDPIIRPGGARAVARAIPGARLRTHPDMGHEIPENRWPDLVADIVATTAEAPGVAAGLAWDPVT
>NC_014666.1|WP_013423755.1|3181643_3182249_-|TetR/AcrR-family-transcriptional-regulator
MPRAVDQEARRRDIAEAVMRLVGSRGLAAASIRAVAAEAGVSVGAVQRCFHSREAMMTFTLGQVNVRLTERFQARVARLPAPATPRDLLRAVLIELVPLDDETRVEARGGLAFLAMAAEDAALAPIVRDTWYAGALDFFRRQLTALHDAAGLAPGTDPELAAHETQVLVEGLRAPLVLGHLSPDQARALLDQHLHRLFDGA
>NC_014666.1|WP_041259256.1|3178874_3181466_-|alpha/beta-fold-hydrolase
MRAFLTGRRRPAAIAAAVVLAVLAALIAVAVSRPDAAIRTQSRFVTGTPENGGRVMLDTTLYLPRSTPAPAILLAQGFGGSKDDLDTAAHALATHGYVVLAYTARGFGRSGGLVHLDAPAYEVADASKLVTYLATLPQVLKDSPGDPRVGVAGSSYGGALGLLAAAQDKRVDAVAADITWNDLSTALFPNAGATDPGVFKKQWAGVLFSSAAGQQPGACGRFAPDLCAAYQHAATTGQSDGAMLSLLRASSPATVLDRITAPTVLIQGEQDSLFPLGQADANARGLAAHGTPVKEIWRSGGHDGTTSAKELAGYVADWFGPVLLRHGQPDTSFEVAVPGSAISTDTGQAVARTLRADDATTSRRTSHLTVAGPPQTVYAPAGGSPAAVTSVPGLGALLSTVTALGGATAPLSGSAGLATIPGQVAAFASAPLPRSMLVAGSSTITIQVAARGATDATLFASLADLDPDEGLRLPNGLVAPIHLTGLRPGVTRTVTVTLPAIVTSVPAGHRLVVTVGTTDSAYQLPTSPRAYTVALDNASLQGDLTVAGIDGRTARAGGLPWGWLLAGVAAMALLLAGVLVSGARRRARRVVVDELAAVPVVIDGLVKEYGDGFRAVDGVSFRVERGQVVGLLGPNGAGKTTALRVLMGLIRPTAGTVHVFGERVEAGAPVLSKVGPFIEGPGLLPHLSGRDNLRLFWAATGRPARDAQFDAALEIAGLGTSVERRVKTYSQGMRQRLAIAQAMLGLPELLVLDEPTNGLDPPQIAEMREVLRRYAATGRTVVISSHLLAEVEQTCTHVVVMHKGKLVAAGSVREIVGAGAPRLVVDDAEKARQILATAGVSAQVTPAQRSLEEVFLRMVGADQ
>NC_014666.1|WP_013423753.1|3177876_3178878_-|ABC-transporter-permease-subunit
MTVPPTDAPPPTDAPPATDSLPPRDALDGFRPPPTQRGAHDLLMDVAEAHDNGFRPERTLRARVEFVRQLRRRRTLFVGLILLLLPLAIALAFQVSSPDSSSQQDSGNFQGQLLVTLATKGAINFALFTESASASFLLVVLVALFCGDTVASEASWSSLRYLLAIPVPRPRLLRQKLIVALSLSLSTNVLLPGWALVVGGLFFGWARAQSGTGGSFTTGEGLTRLLIVVAYVSLQSLLVAALAFLLGVVTDAPLGAVGGATMVMVLSTILDSITALDPYRRFLPTHFQYAWLDALGPDIQWDNMMRGTGVALVYSAAFFALAWWRFQRKDIVS
>NC_014666.1|WP_157734919.1|3177308_3177860_+|Rrf2-family-transcriptional-regulator
MHRVRVTIPGHLLSGSRVCRYAGFVRLSGGVETALHCCVVLTAAAEPVPAARLAELHGVSATYLAKQLQALSRARLVQSVQGKAGGYVLTRPPEEIKVLDVVEAVDGAAPTFVCTEIRQRGPLAAPPEACAAPCAIKRTMIAADQAWRAVLREVSVADLARMVGQGYDTDVMGSVGAWLAAGA
>NC_014666.1|WP_013423751.1|3176551_3177286_-|SDR-family-oxidoreductase
MKITVLGTGLIGAQVARDLTAAGHDVAAHSRSTGVDLLTGAGLDDAVHGAEVVVDVTNSPTFDDASLEFFRSSVTHLLAAAAKAGASHVVALSIVGVDQVPDLPYYRAKTLQEDLIKAGPVPYSIVRATQFHEFVPTVLDLTTDGDVVRLPATPIQPIAAAEVAAAVAEVATGAPLRGTRDLGGPEVFALDELGRITVAATGDGRTVVTDDTAGLFAPVKGDVLTTGEGAHLATTRYRDWLRSR
>NC_014666.1|WP_013423750.1|3175110_3176448_-|NAD(P)/FAD-dependent-oxidoreductase
MRQILIVGGGYAGFYAAWRLERKLRSGEAEVTLVDPRPYMTYQPFLPEVMAGSVEARHAAVSLRRHLRRTRVVAATVTAVDHAHRSVTVQLPDGETRALGYDLIVVTAGAVTRKIPVPGIAEQAIGLKHVEEAVAIRDRLLTAFDRAAALAPGPRRQRLLTVAVVGGGFSGVEAFGELLSLATALLKRYPELRRDELRFHLVEAFGRILPEVTDRPGRWVVRSLERRGARVHLNTQVTSAVDGHVVLSTGDEFDAELIVWTAGNGVNPVIGRHTDLPVDERGLVVVRPDLRVGTESDPVPDAWAAGDDAAVPDLASPVAGAHTVANAQHAYRQGKLLARNVIATLRGREPKAYVHHSLGTVATLGIGRGIFQYRRLVITGLPAWLMHRGYHVLAIPTWERKVRVFAVWATAALFGRDILSLAAVQRPRDAFVTGGEPAALPAEPG
>NC_014666.1|WP_049806886.1|3174075_3175005_-|NAD-dependent-epimerase/dehydratase-family-protein
MLTGEKILITGPAGRIAYGLARSLAADNEVWGIARFSDPDSRAKVEALGVTTRAVDLADGPLDALPTDFTVLLHLAADFSPDDYDRAIRVNAEATGRLLEHCRRARAALVMSTVSTYKPHPDPWHAFAEGDPLGDSMAPPSAPYSVSKIAQEAVARYCARSFGLPVTIARMGCAYGDQGGLPIWHLAAVAAGEPVRTRWDPMPYSPIHDDDICAQVEPLLGAASVPATIVNWAGDDAVSVQQWAAYFGELLGAPAEVAVEPIPGASVGSVGDHTRRASITGPCRVGWRDGFRRVAQQLFPDRLAAVEPR
>NC_014666.1|WP_041260713.1|3185328_3186021_+|aminopeptidase-P-family-protein
MTEDDDPRAAKLLDAQAKAVELFAAVERRGLLAPGVTEVQASDAIRDLAARLFGVSRHWHKRIVRAGPNTLLPYAENPPDRPIGTDDIVFCDLGPIFEEWEADLGRTYVVGDDPVKKRLLDALPQVWNGGREFFETHPDVTGEQLFAQLTLLAEQAGWEFGGPIGGHLIGQFPHDRIPGNKIELYVTPGSDKPMRRTDQAGRPCHWILEVHLVDRDRQIGGFHEELLDLG
>NC_014666.1|WP_013423761.1|3186156_3186993_+|helix-turn-helix-domain-containing-protein
MYDERRARTVAATVWRAVADGGARPAGGSGPGRSAAASAPGGLGVADGAGGSGPIGAGAAGPGPAAHRVLPDGCMDLIWSRAGLGDIGQIIVAGPDTAATVTLWRPGVVHLGLRFDSAVGPAHIGVPASEVRDRRVPLAEIWGRAEAARLAERLAAADASAATFEAEIVRRGRRDGLADLLAPSALASIRAGAPVAQVARTAALSERQLLRRCQLAVGYGPKTLARIVRFRRALALARGGTPFAAVAAEAGYADQAHLAREVHSLGGAPLGELIAPTA
>NC_014666.1|WP_013423762.1|3187045_3187831_-|class-I-SAM-dependent-methyltransferase
MAGDLFTGTAEYYARHRPGYPPAFLAEIGQRLSLSGAGRLLDLGCGPGTLALALAGQVGEVIGVDPEPDMLAEAARQTDLAGIQNVRWVKAHAEDLAPDLGVFQLVTMGRSFHWMRQDRVLESLAEMVAPAGGLAIVNDSCLVRPETDWQRSVEAIQEKFVGTVGRAGNGVLLPPAESMETVLRRSAFRRIDRIVYEFERQWTVEQIIGYMYSTSVPIRRLLGDRRTSFEKEMTEVLTRHSSDHRFTEPVRLAAYFAFREA
>NC_014666.1|WP_157735406.1|3188257_3188476_-|hypothetical-protein
MGHQPHARCGEIGHRATDCRAADHGRPANRTCAHNSAFPETRNRPQPRRPQSTDCTGTRSDHLPRKTKEAIQ
>NC_014666.1|WP_041259261.1|3188655_3189972_+|DUF222-domain-containing-protein
MVDGVFDEVLAGLGSCDASATVALAGRLARLTARLEGVAIHVQVQLARQRPANPAVGDGEGGDAYSPFVADELAAALGQSPRTMSGRLATAWEIANRLPAALADLTAGMLDHTRLAALHQLTTCLTDGQRAVVEAAMLAGSRLASPPRWRRKIHRLVARLDPDAAAKRRRHAHTQRGIAIQSLQDGTACLTAILAAEDAQAIYDRINHIARTDAHTDLHTDGGVRPIDARRADVLTALLLGNRREHVSVELQVIAPVGTLAGLDDNPAELVGYGPIPAEVGRALAADARWRRVLTDPATGTVLDLGHRRTPTPALARLVRHQQTRCVFPGCGMPATHTDLDHTTAHSHGGRTALDNLGLLCRRHHTAKHRGGWKLHQPRPGVFTWTAPTGRTYTTDTTTNQEEANSQTAACATACVNSRPTPPTIPNQRVSSGTRYPF
>NC_014666.1|WP_041260714.1|3190291_3190684_-|glyoxalase
MPTFSLTGIVVSDMARGLAFYRRLGLEIPAAADTEPHVEVTTPNGRLAFDTDATIRSFDPDWRAGTGSPRVALAFACADPAEVDKVYADLTDAGYTGERPPWDAFWGQRYATVADPDGNHVDLHAPLAGA
>NC_014666.1|WP_157735407.1|3192080_3193442_-|cytochrome-P450
MAQPSGASHGYAPHAYAPEVVFDAFDSEHWPNPYPRYAVARAARPLFPTPLGVHLVTRYEDCAAILQDDTWSHAHEAQLFHPGVDTTDLPASFLWMDPPDHTRLRGLVSKAFTPRTVAALRPRVERLVRELFDAILAAGETGDAGEADAITALAYPLPLTVIAELIGAPAADHPDLQRWSRALARGFDPDPLLTPEEREGRSAAAREFVAYFRGLIAWRRAEPADDLISELAAVEERGDVLTEDEVLATCVTLLVAGHETSVNLVANGLLALIRHPDQYALLRSSPELVVPAVEEMLRYDSPVHLTTRLAHRRTELAGRTFEAGDGVALLFGSANRDPAAFPDPERFDVTRYAGRSPARRHLTFSLGIHYCLGAPLARLEMELVLRELLRRGLTMTLLTDRLAYRRNLVLRGLASLPVRFEEPGVPAPRLAAGRGSGRLAGRGSGQRAGLDPS
>NC_014666.1|WP_013423767.1|3193656_3194868_-|cytochrome-P450
MSTAPEVVFDAFHPVHRSNPYPRYAAVREFAALYPIRPDILMATRYEECSAVFTDALWGHGYEDGINPFRPGVAPDDVPGSMVRMDPPTHTRVRGLVKRAFVPRTTEGLRGRIEGLVGTLLDAAIEAGEVDLMEAFARPLPLTIIGDLLGIPPADYPEVQKWSLEIVRGTDPDILQSPECLARRSEAMLEFEAYFAGLLALRRADPREDMLTGMAAAEDRGELTGREALGLASGLLIGGYETVSDVIGKGVVALLRNPDQIALWLADPELAGPAVDELLRYEPPVQFTHRVALAEREVAGHTFARGEGIVILTAAANRDPAVYTDPERLDITRFAGRSPAPRHLSFSEGLHYCLGAHLGRLETQLAVDTLLRRSPALRLAGEPVWRDTVAIHGLDTLPVRLRN
>NC_014666.1|WP_013423768.1|3194974_3195787_+|amidohydrolase
MPVIDAWLQHPTLRHANHEMFEPLRRWTGREAPIEAPPVEATLAELRAADVEIGLTTAWYGPQGPLISNDEVAGFVAQSGGRLRGVAGVDLTRPVEAVRELRRAVRELGFVALRVLPWLWQLPPTDRLYYPLYAACVDLGVPFCTQVGHTGPLRPSETGRPIPYIDQVALDFPELTIVCGHIGYPWTTEMIAVADKHAGVYIDTSAYTTRRYPAELVDYLRGRGRHKVLFGSNYPMITPARALEHLADLGLDEQARELFLAGNARRVFSL
>NC_014666.1|WP_013423769.1|3196024_3197473_+|MFS-transporter
MSATASEIQSPSTAPAHIQLPGRAFLPVVLAGTGMVVLDIFIVNAAIPAIERDFHAGPNSLEWLVTAYNLAFAAAMILGGRLGDCFGRRRVFAAGLALFTGMSVLCGVADGTAALIAARAGQGLAAAALVPQVSAILNLAYDGPARARAYTCYALTLGGAAVAGQIVGGGLIAADVAGLGWRACFLVNVPIGVAALALTRRHVPAGRPTGVRPRLDLVGAALVTAALVAVVLPLVEGPGAGWPWWSWGCLVVAAVLFAVLVAAQRRIAARGGSPILPPALFTGRTFVVGLVNVVVFNASVASWFFVLALYLQDGRHLSPLRAGLVFSALGGGFLVTSLAGGRVVARLGRQGLALGSGLRVLGLLALWGVVRAHGTGGGLLWVTLPLAVEGAGQGLVTGPLISRVLLGVRPAVAGAGSGVLASAQQVGNSIGVAVIGAVFFAARHAGGSIADAFGAGLLLLAALSLVVAALVQLLPNTPARGG

Crispr_ID: NC_014666_10

• CRISPR_ID: NC_014666_10
• CRISPR_location: 3247569-3247672
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_014666_10

Consensus_repeat	Method
GCGAGGCGACAAAGGTCAACCGCGGCGCGCTCGTCGC	CRISPRCasFinder

spacers of NC_014666_10

>10.1|3247606|30|NC_014666|CRISPRCasFinder
CGCGCGGGGCGGCTGACGGAACGTCCCAGC

CRISPR arrays and Neighbor proteins around NC_014666_10

CRISPR arrays

The CRISPR arrays of NC_014666_10

>merge|NC_014666|10|3247569-3247672|CRISPRCasFinder
GCGAGGCGACAAAGGTCAACCGCGGCGCGCTCGTCGCCGCGCGGGGCGGCTGACGGAACGTCCCAGCGGCGAGGCGAAAAGGTCAACCGCGGCGCGCTCGTCGC

>NC_014666|10|8|3247569-3247672|CRISPRCasFinder
GCGAGGCGACAAAGGTCAACCGCGGCGCGCTCGTCGC	CGCGCGGGGCGGCTGACGGAACGTCCCAGC
GGCGAGGCGAAAAGGTCAACCGCGGCGCGCTCGTCGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_014666.1|WP_013423821.1|3250441_3251098_-|Clp-protease	unknown	unknown	gnl|CDD|214361
NC_014666.1|WP_013423816.1|3244463_3245882_+|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|380564
NC_014666.1|WP_157734921.1|3242483_3243911_-|hypothetical-protein	unknown	unknown	gnl|CDD|223021
NC_014666.1|WP_013423810.1|3238528_3238984_+|tellurite-resistance-TerB-family-protein	unknown	unknown	gnl|CDD|226316
NC_014666.1|WP_013423822.1|3251401_3252136_+|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|235975
NC_014666.1|WP_013423820.1|3249974_3250346_+|hypothetical-protein	unknown	unknown	unknown
NC_014666.1|WP_013423809.1|3237698_3238388_+|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|225107
NC_014666.1|WP_041259275.1|3239810_3240653_-|TIGR03620-family-F420-dependent-LLM-class-oxidoreductase	unknown	unknown	gnl|CDD|274681
NC_014666.1|WP_013423823.1|3252171_3252966_+|enoyl-CoA-hydratase	unknown	unknown	gnl|CDD|119339
NC_014666.1|WP_013423819.1|3248561_3249722_-|cytochrome-P450	unknown	unknown	gnl|CDD|225035
NC_014666.1|WP_041259279.1|3256203_3256389_+|hypothetical-protein	unknown	unknown	unknown
NC_014666.1|WP_157734920.1|3236131_3237331_-|amidohydrolase-family-protein	unknown	unknown	gnl|CDD|368185
NC_014666.1|WP_007509185.1|3235640_3235943_-|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl|CDD|225209
NC_014666.1|WP_041260730.1|3239036_3239756_+|ABC-transporter-permease	unknown	unknown	gnl|CDD|377092
NC_014666.1|WP_013423826.1|3256535_3257783_+|AbrB-family-transcriptional-regulator	unknown	unknown	gnl|CDD|377472
NC_014666.1|WP_013423813.1|3240834_3241992_+|hypothetical-protein	unknown	unknown	gnl|CDD|367389
NC_014666.1|WP_013423814.1|3242040_3242466_+|PPOX-class-F420-dependent-oxidoreductase	unknown	unknown	gnl|CDD|274925
NC_014666.1|WP_013423824.1|3253581_3254709_-|ADP-ribosylglycohydrolase-family-protein	unknown	unknown	gnl|CDD|377122
NC_014666.1|WP_013423818.1|3247704_3248514_+|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|366102
NC_014666.1|WP_157734922.1|3255465_3256113_+|glycine-zipper-family-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_014666.1|WP_013423821.1|3250441_3251098_-|Clp-protease	gnl|CDD|214361	CHL00095, clpC, Clp protease ATP binding subunit.	2.48648e-21
NC_014666.1|WP_013423816.1|3244463_3245882_+|ABC-transporter-substrate-binding-protein	gnl|CDD|380564	cd06341, PBP1_ABC_ligand_binding-like, type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions. This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. Members of this group are sequence-similar to members of the family of ABC-type hydrophobic amino acid transporters such as leucine-isoleucine-valine binding protein (LIVBP); however their ligand specificity has not been determined experimentally.	3.30545e-31
NC_014666.1|WP_157734921.1|3242483_3243911_-|hypothetical-protein	gnl|CDD|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	4.66409e-06
NC_014666.1|WP_013423810.1|3238528_3238984_+|tellurite-resistance-TerB-family-protein	gnl|CDD|226316	COG3793, TerB, Tellurite resistance protein [Inorganic ion transport and metabolism].	7.27813e-24
NC_014666.1|WP_013423822.1|3251401_3252136_+|SDR-family-oxidoreductase	gnl|CDD|235975	PRK07231, FabG-like, SDR family oxidoreductase.	5.37091e-73
NC_014666.1|WP_013423809.1|3237698_3238388_+|response-regulator-transcription-factor	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	5.33689e-41
NC_014666.1|WP_041259275.1|3239810_3240653_-|TIGR03620-family-F420-dependent-LLM-class-oxidoreductase	gnl|CDD|274681	TIGR03620, F420_MSMEG_4141, probable F420-dependent oxidoreductase, MSMEG_4141 family. Members of this protein family, related to F420-dependent oxidoreductases within the larger family of a bacterial luciferase (an FMN-dependent enzyme), occurs only within the small subset of species that synthesize F420. Most such proteins are from members of the Actinobacteria, but at least one species, Sphingomonas wittichii, belongs to the Alphaproteobacteria. [Unknown function, Enzymes of unknown specificity].	1.10622e-81
NC_014666.1|WP_013423823.1|3252171_3252966_+|enoyl-CoA-hydratase	gnl|CDD|119339	cd06558, crotonase-like, Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.	9.753e-53
NC_014666.1|WP_013423819.1|3248561_3249722_-|cytochrome-P450	gnl|CDD|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	3.02593e-83
NC_014666.1|WP_157734920.1|3236131_3237331_-|amidohydrolase-family-protein	gnl|CDD|368185	pfam04909, Amidohydro_2, Amidohydrolase. These proteins are amidohydrolases that are related to pfam01979.	2.11153e-20
NC_014666.1|WP_007509185.1|3235640_3235943_-|antibiotic-biosynthesis-monooxygenase	gnl|CDD|225209	COG2329, COG2329, Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only].	4.13467e-25
NC_014666.1|WP_041260730.1|3239036_3239756_+|ABC-transporter-permease	gnl|CDD|377092	pfam03649, UPF0014, Uncharacterized protein family (UPF0014).	3.79454e-55
NC_014666.1|WP_013423826.1|3256535_3257783_+|AbrB-family-transcriptional-regulator	gnl|CDD|377472	pfam05145, AbrB, Transition state regulatory protein AbrB. Bacillus subtilis respond to a multitude of environmental stimuli by using transcription factors called transition state regulators (TSRs). They play an essential role in cell survival by regulating spore formation, competence, and biofilm development. AbrB is one of the most known TSRs, acting as a pleotropic regulator for over 60 different genes where it directly binds to their promoter or regulatory regions. Many other genes are indirectly controlled by AbrB since it is a regulator of other regulatory proteins, including ScoC, Abh, SinR and SigH. Hence, AbrB is considered a global regulatory protein controlling processes such as Bacillus subtilis growth and cell division as well as production of extracellular degradative enzymes, nitrogen utilization and amino acid metabolism, motility, synthesis of antibiotics and their resistant determinants, development of competence, transport systems, oxidative stress response, phosphate metabolism, cell surface components and sporulation. AbrB is a tetramer consisting of identical 94 residue monomers. Its DNA-binding function resides solely in the N-terminal domain (AbrBN) of 53 residues. Although it does not recognize a well-defined DNA base-pairing sequence, instead, it appears to target a very weak pseudo consensus nucleotide sequence, TGGNA-5bp-TGGNA, which allows it to be rather promiscuous in binding. The N-terminal domains of very similar sequences are present in two more Bacillus subtilis proteins, Abh and SpoVT. Mutagenesis studies suggest that the role of the C-terminal domain is in forming multimers.	3.49364e-58
NC_014666.1|WP_013423813.1|3240834_3241992_+|hypothetical-protein	gnl|CDD|367389	pfam03200, Glyco_hydro_63, Glycosyl hydrolase family 63 C-terminal domain. This is a family of eukaryotic enzymes belonging to glycosyl hydrolase family 63. They catalyze the specific cleavage of the non-reducing terminal glucose residue from Glc(3)Man(9)GlcNAc(2). Mannosyl oligosaccharide glucosidase EC:3.2.1.106 is the first enzyme in the N-linked oligosaccharide processing pathway. This family represents the C-terminal catalytic domain.	1.1674e-06
NC_014666.1|WP_013423814.1|3242040_3242466_+|PPOX-class-F420-dependent-oxidoreductase	gnl|CDD|274925	TIGR04023, Pyridoxamine_5'-phosphate_oxidase, PPOX class F420-dependent enzyme, MSMEG_5819/OxyR family. A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomycetales, make F420. This subfamily within the PPOX family occurs in at least 19 distinct species of F420 producers and is likely to bind F420 rather than FMN. The member OxyR was shown to use F420 to catalyze a C5a-C11a reduction in oxytetracycline biosynthesis. [Unknown function, Enzymes of unknown specificity].	1.32196e-38
NC_014666.1|WP_013423824.1|3253581_3254709_-|ADP-ribosylglycohydrolase-family-protein	gnl|CDD|377122	pfam03747, ADP_ribosyl_GH, ADP-ribosylglycohydrolase. This family includes enzymes that ADP-ribosylations, for example ADP-ribosylarginine hydrolase EC:3.2.2.19 cleaves ADP-ribose-L-arginine. The family also includes dinitrogenase reductase activating glycohydrolase. Most surprisingly the family also includes jellyfish crystallins, these proteins appear to have lost the presumed active site residues.	1.09096e-55
NC_014666.1|WP_013423818.1|3247704_3248514_+|helix-turn-helix-transcriptional-regulator	gnl|CDD|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	1.68328e-09

Protein sequences

>NC_014666.1|WP_013423816.1|3244463_3245882_+|ABC-transporter-substrate-binding-protein
MNLRVTRVSTDRPARRTRHGRARLSGAARLSGAAPSFSAARLFSAAPLFGAARLSGLTRRSRVPLVVVLAVGVGLVAACGGSGGGTATPAASAGAASALLGPVARATGTPVKIGIITEGKSAISDMSAQDTVADATAKWLNEHRSGIAGHPIELVKCDALGDPGKAADCGNRLVEANVAAAVFGETAVMAAAWKPLHDAHVPVMLYATSDAGPLLDKDSTFVLSDPTAGTIGMPISVAKSLGLKKLTAIVIDVPSAVGLETTVAPAQAKAAGLDFNLVRIPPGTADMTPQLQPVVAGDPGLVFVLGNDSFCISAFNGLRSAGFTGHITSIAQCVTDATRKAVPGSLLNGMQISASSPIGLDNPSTRLYKAVVATYSKGVDTSQQGGMSMFSALAGFQTSVARLTGDITPTSVLSAIRSMPSTELPGAGGLTFQCDGKASTLASSVCTRGSLVATLDAKGQPRSYQVVGASAG
>NC_014666.1|WP_157734921.1|3242483_3243911_-|hypothetical-protein
MTLKRTARTLALLAVAVATAAGCAPGGLPAGGGGTGPVGTPTSSPPVRSSASPSLPPATTPPRATTPATAPATAPVTSTPPGTATSSAPAAGACGRAAGTAPTTRITDVPLGSQVVSFGPQGDTDPLPTAITAAPGGGSWLAWLSPDSQVHLGRLDCDDHLVGATTTVAGVDLQDIRADAQGVVVLLTRPGPQGNGTLCGGTSSPTRAMWMVRFDNAGRQVWERQVTNLSASLGGYDPGALFVWWYNHHGTLAFDGANYAAYFEAAITVANGGCVDIHEGDRMQVVNATTGALVPGHDSFAWGCSHAWDSHITWDSRTGHFAMVCATDNNCRIARPGTGQTVASGACDGTLFGGDLVLAGAQGYWTAWSNGGQARLEHFAAGASDHTVVTADRTEHSHLVAYGPARMLLTWRSGSATAAQVYDSTTGAAVGAPFTIAAADHTYVEAKDYPDGSVAFPAVGATGSSVRIVRVMPLR
>NC_014666.1|WP_013423814.1|3242040_3242466_+|PPOX-class-F420-dependent-oxidoreductase
MTFTDAEQRFLARQPRGHLSTIGPDGVPQVKPLGFTVNAELGTIDIAGFAMASSAKYRNVRANPLVAFVVDEVTEQTMEGAHFLEIRGVAETVTRPAGDGHLAPEIIRIHPRRVVAYNVDPDRPGLHTRDVAAEESAAARA
>NC_014666.1|WP_013423813.1|3240834_3241992_+|hypothetical-protein
MITDGAAAVLAACWRDEYCVPNPEVYPHLWLWDSCFHAISWAALGDRRASVELASCLDAQLPNGFVPHMRYASPSEGRGPLPDRSSFTQPPIYAHAARVLADRGLPVAADTLARIERALDHLWTHRMGSDGLLYIVHPWESGSDDSPRFDDWVGRSTWSRLAFTIVDHQLVDSTEFDEQGAARWSRDFVVAPAAFNAFAAHAAAELAALTGDPAWRRRSGELAGAIDDVLWDADQNHWVDKPIVGGGPSALIPTLDGLTPLLVTADPAKARAALVLAADPAGYAAPFGLRFVPAGHPRYSPEQYWRGPAWPQLNYMLYQAARRWEAAPLAEAIADASRRAAVASGFAEYWNPETGAGLGARPQGWAALAATYPPVPTQAAPVAAS
>NC_014666.1|WP_041259275.1|3239810_3240653_-|TIGR03620-family-F420-dependent-LLM-class-oxidoreductase
MTIAGPIGIAGLGLDATAEPAAQTAAATRLAELGYQTLWLPGGQGNNLAQISGIVRATTDLRVASGIVPVLQVPAAEVAATYAALEVDHPGRFVVGLGGAHGPKPFPALNAYLDTLDTEAPVVPASARILAALGPRMLNLARDRAAGAYPYLVTPDYVAGARALLGAGPTLAVLVPVIPLADPGAARELARASTGFFTTVPGYRANFARMGFADADITELRDAFVDGITVWGDLESIVARVAEFHAAGADQVVLGLRLPAEAAASETAAWQARLAEALLS
>NC_014666.1|WP_041260730.1|3239036_3239756_+|ABC-transporter-permease
MAVSLGLLLILAVAAQSYGRLRLRAAVLTAALRAVVQLAAVGLVIRSVFAAPAASFAVLAVMAAVATRTAARRLAELPGAGRAVVIASLSAAALTLGVLFAVPALPRSPRYLVALGGIVLGGTMTACTLAGRRLLDGLRRRRDEVEAWLALGATPRQAVADIARTAASEALLPALDQTRTVGLVTLPGAFVGALLGGASPLDAARFQLVVLIALLAAETYAAVVLVWLLGAPTQLPALD
>NC_014666.1|WP_013423810.1|3238528_3238984_+|tellurite-resistance-TerB-family-protein
MPIWDRLRTSTQTMQGQLTAKKNELKSGAFRDASMAICALVAAADGTVDPAERQRVAGLIAANDVLANFPADDLQRRFNDYLVKLQQDFAFGKVSVLQDIGKTKKKPAEARAVIQIGIIIGGADGNFDKSEQAVVREACFAVGISPDEFDL
>NC_014666.1|WP_013423809.1|3237698_3238388_+|response-regulator-transcription-factor
MAGGTPLPAASGAPGPLTVALVDDYDVVLAGVARILTPYQDRVRVVEIDTNRPVAQDVDIVLYDSFAQPEAGGEELADIVANEHTGRVVIYTWNFHETLVESALARGASGYLSKTLAARELVAALEAVHAGEVVVSPPPRSRTVAGLDWPGRGEGLTEREAEVLALITQGRSNAELAEITCLSPNTVKSYIRTLYRKIGVTSRSQAVLWGVNHGFAPDFHRIQSWRVRM
>NC_014666.1|WP_157734920.1|3236131_3237331_-|amidohydrolase-family-protein
MPRIRTRRGVFVRDENTLDESQPFQGLDSPAPHRRSLLWGAAALGAAALAPSAAATASAAATPSAAPSPSAAAPSPAPAANANGRIDVHHHAIPPAAHQWMVDHGLLPPVGGPPWANWTAESSLAIMDETGVAASVLSGPAPSEFLTSLTPAQIAESTRVGNDALGQVISDHPTRFGFFAAAPVANVDVALTEIGYSLDTLHADGVVLSMHAGGQYLGDPAFDPILAELDRRHAVVFTHPYNLPGCSGAPVPDFLVDFLADTTRAAVKMLLAGVFDRYPNISFILPHGGGFFPLLASRLQLGSYLGVGVSQAVATRAIRRCWYDSAAPISPGATPSLLAAVGAEKLLFGSDFPASTADGARLNARAIDTDPVLSPGVRRQINRENARRLLPALAQRIGG
>NC_014666.1|WP_007509185.1|3235640_3235943_-|antibiotic-biosynthesis-monooxygenase
MKINAIEVPEGAGPELEKRFANRLHAVDGQPGFVSFELLRPVKGDNRYFVVTHWDSEESFQAWLTGPAMEAHSGERARPVASGSSLLEFEVVQRSVAGGS
>NC_014666.1|WP_013423818.1|3247704_3248514_+|helix-turn-helix-transcriptional-regulator
MSHPYTDRPPRPDRRGDLAGLVAVSAAAKGSVNAVSWAERAADRSPSVQRSRLRTIQQAKLIVQAARRLVNEKGDQFTTQELAREAGVALQTFYRHFPGKDQLMVAVIEDLIAESAEAYAEAAKELPDPVARLRYYVLAMLSGLDAARGAGASSGGADGAANEAGPRFVTAQHWRLHQRFPEDMAHAIQPITDLIATELRAGEAAGLLHPTDVDRDAALVTKLLMTVYHHHAFAPSEQPIDEIAGHLWAFCLAAVGGAAPPREPAGPGA
>NC_014666.1|WP_013423819.1|3248561_3249722_-|cytochrome-P450
MENPAFLAAPQAIFPALRARGAVAVGDRAVLLTRNADIATLLTNPEVFSSGVGVTETGAKRPLIPLQIDPPKHREYRKILDPLFSPQRMKEMEGPISELARGLIDTIAAQDEVDFVQRFSTQFPSQVFLTLLGLPLDELPTFLTMKDGFIRPESITGQPRGHEDSIALLTKTSDSIYEYFDAVIADRRAHPGEDIVSRFLETEVEGARLSHEDIVDICFLFFVAGLDTVSASLDCMMLHLATHPERRRALVNDPGLIPNAVEELLRWESPVMMVARVATQDTEIAGCPVSKGMVVTGLLGAANTDEQEIAEPDVVRFDRATNRHIAFGRGPHRCLGSHLARLELRIALREWHARIPEYRVPDGFEPAFTTTIRSLVTLPLQPGQAG
>NC_014666.1|WP_013423820.1|3249974_3250346_+|hypothetical-protein
MRGVSKIKSIALIMGVGAPLAVIPVAAAPAVAGTINNPLKVAGSVRCKLGSAESLLITGGGESHGTTVGPGGMFSIVFGNPNLPSTATAQVRCDIAGQRTYRSTNFLLYRPQGGQVLNVSLVA
>NC_014666.1|WP_013423821.1|3250441_3251098_-|Clp-protease
MHDLLNDHARRLLVLAQGEALGLSHDEIATEHLLLGALDRRIGSGAAALASLGVTHDRAHTEIVRIVGHGSGRGMARGRGRAGRARSLPLSLRAQWILERARREAAAIDHTSVGSEHILLALLREDGGHAFRVFERLRVNRDEAHRRVLVALDVLPYPGPTLLDGIAGNLDARIEQVRAAKDDALDRRDFGLAVEFRQVERNLVAQQAPSGETASRTA
>NC_014666.1|WP_013423822.1|3251401_3252136_+|SDR-family-oxidoreductase
MGVLAEKVAIISGAARGQGLAEAERFVAEGARVVLVDRLAEAVEAAAGRLGDAARFVAGDVADERAWTDAVALATDQFGGVDILVNNAGVMVSRSLVDTDEATFRDVLDTNLVGAYLGIRAVVPAMRARGGGAIVNTASAAGLKAIPMGSAYVASKFGLRGLSRAAALELGRHQIRVNCVCPGLVRTEMAADLLRYHEKEALANIPLGIAAEATDVADLVLFLVSDAARAISGGEYLIDGASIA
>NC_014666.1|WP_013423823.1|3252171_3252966_+|enoyl-CoA-hydratase
MRPASAWNTLDVSVEGRVAWVRFNRPERRNGVTTEMAVEMYGALTELAGHDDVTVLVLTGAGDTFCPGADLRPAEGASAGARALPAAETYHSARLLRELPAVTIAAVNGACAGAGFAWAAACDLRVASASARFATAFVNVGLPGELGLAWTLPRIVGANRARELLYLSPKLDAEQAREYGFVSRVWSAESFQAELGALVDALAGRRPEALRVMKQSLLEGEHLTLGDYLTVESARYLAMLTGAGAGEVAGRLADQGAALRPAGE
>NC_014666.1|WP_013423824.1|3253581_3254709_-|ADP-ribosylglycohydrolase-family-protein
MLSYRDRVRGCLLGGALGDALGAGIEFLALEEIRARFGPAGVTGMTGGYGVLAPITDDTQMTLFTAEGLIRASVRGRSRGICHPPTVLWQAYQRWLVTQRMTEPPAEVSGWLAAQPVLYARRAPGNACLSGLSQPKMGTLEHPANPDSKGCGTVMRSAPFGLLRRDPEDSWALAVECAVLTHGHPSGYLAAGALAWIMALVIDGSPVLDAARSALAHAQDEPAGAEVATALRRALGAAAEITAGTTGTTGTTGTSIDARTIAGQVEALGEGWVAEEALAIAVFCAVVAADDPAAALLAAVNHSGDSDSTGAICGNLVGAAVGVDALPEDWLAELEGAEVVREIADDLVREITGSADVADRWGGVTVEWSARYPGG
>NC_014666.1|WP_157734922.1|3255465_3256113_+|glycine-zipper-family-protein
MPARPGDPSAAERPGASSSGGPASGRELAWRFPPQQVVASYDTHGQAARAVDHLADHRFPVERTAIVGRGLTSVESIGRMSWRDSTLRTVAGWAVAGAVLGWLLGLLDWASPLRAAFSLALWGLLFGGVLGLFGGLLVRAFYGGGHPSRVTHSQTYRADSYDLLVDTEVAERARSTLVLGGFPVTGAVRQDAAVSGGLRVGDPSEPGRAGASRRS
>NC_014666.1|WP_041259279.1|3256203_3256389_+|hypothetical-protein
MVPDLSVQAVHVTKQAILCATDADARSRLTGTYMIFWVGRRCRGLDRVNRTYACAGAGAAR
>NC_014666.1|WP_013423826.1|3256535_3257783_+|AbrB-family-transcriptional-regulator
MIRTDIATDPGRTFIIIGSNLTETTVGVSAPGPAGCSTGKSRIFSSATGRARARSALGWIALIAICFLLSDLGEHVGIPAAQLLVSMLVGAALALAGVVRRRLPARANRASQVVVGVLMGSYLAPSALSAATGRALPLIGVTLASIAICVAVAGALTRRTRATGVDTTLGLMPGGSAAIVAYATELGADSRFVAFAQYLRVGVVAASTPLIVAALGRNPGSSHSGRSLSFSHLVASPHQVAGLAMLTATGLLGVGLARRLRLPAPALLGPMFLTAAILWTDLTGGFSPAGSLRDIAFVLVGLEVGLRFDLASVRYLGRMLGYLLGASVAVCLACAGLAWALSALVGMSFTDSYLATTPGGINAILATAASAHADLPVIAAVQSVRLLLVIALTAPIIRAATRWRAFRSQRSAALG

Crispr_ID: NC_014666_11

• CRISPR_ID: NC_014666_11
• CRISPR_location: 3547170-3547294
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_014666_11

Consensus_repeat	Method
TTGTTCTTGTCGTTCAGGATCCCGTTCGGGAAGAGGCCGCCGTC	CRISPRCasFinder

spacers of NC_014666_11

>11.1|3547214|37|NC_014666|CRISPRCasFinder
CTTGCCGTCCTTCCCGTCCTTGCCGTCCTTGTTGCAG

CRISPR arrays and Neighbor proteins around NC_014666_11

CRISPR arrays

The CRISPR arrays of NC_014666_11

>merge|NC_014666|11|3547170-3547294|CRISPRCasFinder
TTGTTCTTGTCGTTCAGGATCCCGTTCGGGAAGAGGCCGCCGTCCTTGCCGTCCTTCCCGTCCTTGCCGTCCTTGTTGCAGTTGTTCTTGTCGTTCAGGATCCCGTTCGGGAACAGGCCGCCGTC

>NC_014666|11|9|3547170-3547294|CRISPRCasFinder
TTGTTCTTGTCGTTCAGGATCCCGTTCGGGAAGAGGCCGCCGTC	CTTGCCGTCCTTCCCGTCCTTGCCGTCCTTGTTGCAG
TTGTTCTTGTCGTTCAGGATCCCGTTCGGGAACAGGCCGCCGTC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_014666.1|WP_083819733.1|3548305_3549127_+|class-F-sortase	unknown	unknown	gnl|CDD|320678
NC_014666.1|WP_157735423.1|3539243_3539885_+|SMC-Scp-complex-subunit-ScpB	unknown	unknown	gnl|CDD|377219
NC_014666.1|WP_041260815.1|3551886_3554394_+|NTP-transferase-domain-containing-protein	unknown	unknown	gnl|CDD|100097
NC_014666.1|WP_083819554.1|3542289_3543072_+|(d)CMP-kinase	unknown	unknown	gnl|CDD|234579
NC_014666.1|WP_157734941.1|3554529_3555489_+|DUF881-domain-containing-protein	unknown	unknown	gnl|CDD|377575
NC_014666.1|WP_013424082.1|3551179_3551875_+|CDP-alcohol-phosphatidyltransferase-family-protein	unknown	unknown	gnl|CDD|223632
NC_014666.1|WP_013424069.1|3532969_3537133_+|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|315987
NC_014666.1|WP_013424076.1|3543068_3543902_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl|CDD|153251
NC_014666.1|WP_013424078.1|3545709_3546321_-|hypothetical-protein	unknown	unknown	gnl|CDD|366373
NC_014666.1|WP_157735425.1|3556157_3556796_+|DUF881-domain-containing-protein	unknown	unknown	gnl|CDD|377575
NC_014666.1|WP_157735424.1|3540997_3542137_+|prephenate-dehydrogenase/arogenate-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|235824
NC_014666.1|WP_071587947.1|3544082_3545495_+|ribosome-biogenesis-GTPase-Der	unknown	unknown	gnl|CDD|179525
NC_014666.1|WP_157734940.1|3537240_3537942_+|hypothetical-protein	unknown	unknown	unknown
NC_014666.1|WP_041259330.1|3549743_3550805_+|C40-family-peptidase	unknown	unknown	gnl|CDD|366353
NC_014666.1|WP_013424085.1|3555496_3556000_+|small-basic-family-protein	unknown	unknown	gnl|CDD|377739
NC_014666.1|WP_083819734.1|3556933_3557314_+|glycine-cleavage-system-protein-GcvH	unknown	unknown	gnl|CDD|234918
NC_014666.1|WP_157735426.1|3558573_3559278_+|MerR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|133378
NC_014666.1|WP_083819732.1|3538191_3539130_+|segregation/condensation-protein-A	unknown	unknown	gnl|CDD|224273
NC_014666.1|WP_041260817.1|3557858_3558410_+|FHA-domain-containing-protein	unknown	unknown	gnl|CDD|238017
NC_014666.1|WP_049807180.1|3540158_3540881_+|pseudouridine-synthase	unknown	unknown	gnl|CDD|224108

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_014666.1|WP_083819733.1|3548305_3549127_+|class-F-sortase	gnl|CDD|320678	cd05829, Sortase_F, Sortase domain found in the class F family of sortases. Class F sortases are mainly present in Actinobacteria, Chlorobacteria and Firmicutes. Their functions are largely unknown.	8.0928e-53
NC_014666.1|WP_157735423.1|3539243_3539885_+|SMC-Scp-complex-subunit-ScpB	gnl|CDD|377219	pfam04079, SMC_ScpB, Segregation and condensation complex subunit ScpB. This is a family of prokaryotic proteins that form one of the subunits, ScpB, of the segregation and condensation complex, condensin, that plays a key role in the maintenance of the chromosome. In prokaryotes the complex consists of three proteins, SMC, ScpA (kleisin) and ScpB. ScpB dimerizes and binds to ScpA. As originally predicted, ScpB is structurally a winged-helix at both its N- and C-terminal halves. IN Bacillus subtilis,one Smc dimer is bridged by a single ScpAB to generate asymmetric tripartite rings analogous to eukaryotic SMC complex ring-shaped assemblies.	2.3382e-63
NC_014666.1|WP_041260815.1|3551886_3554394_+|NTP-transferase-domain-containing-protein	gnl|CDD|100097	cd05805, MPG1_transferase, GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an N-terminal NTP transferase domain, an L-beta-H domain, and a C-terminal PGM-like domain that belongs to the alpha-D-phosphohexomutase superfamily. This subfamily is limited to bacteria and archaea. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this group appear to lack conserved residues necessary for metal binding and catalytic activity. Other members of this superfamily include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.	8.51558e-174
NC_014666.1|WP_083819554.1|3542289_3543072_+|(d)CMP-kinase	gnl|CDD|234579	PRK00023, cmk, (d)CMP kinase.	6.02235e-91
NC_014666.1|WP_157734941.1|3554529_3555489_+|DUF881-domain-containing-protein	gnl|CDD|377575	pfam05949, DUF881, Bacterial protein of unknown function (DUF881). This family consists of a series of hypothetical bacterial proteins. One of the family members YlxW from Bacillus subtilis is thought to be involved in cell division and sporulation.	2.98948e-30
NC_014666.1|WP_013424082.1|3551179_3551875_+|CDP-alcohol-phosphatidyltransferase-family-protein	gnl|CDD|223632	COG0558, PgsA, Phosphatidylglycerophosphate synthase [Lipid metabolism].	5.55778e-26
NC_014666.1|WP_013424069.1|3532969_3537133_+|tetratricopeptide-repeat-protein	gnl|CDD|315987	pfam13424, TPR_12, Tetratricopeptide repeat.	4.17205e-07
NC_014666.1|WP_013424076.1|3543068_3543902_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl|CDD|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	1.65059e-43
NC_014666.1|WP_013424078.1|3545709_3546321_-|hypothetical-protein	gnl|CDD|366373	pfam00929, RNase_T, Exonuclease. This family includes a variety of exonuclease proteins, such as ribonuclease T and the epsilon subunit of DNA polymerase III.;.	9.39239e-06
NC_014666.1|WP_157735425.1|3556157_3556796_+|DUF881-domain-containing-protein	gnl|CDD|377575	pfam05949, DUF881, Bacterial protein of unknown function (DUF881). This family consists of a series of hypothetical bacterial proteins. One of the family members YlxW from Bacillus subtilis is thought to be involved in cell division and sporulation.	5.81362e-31
NC_014666.1|WP_157735424.1|3540997_3542137_+|prephenate-dehydrogenase/arogenate-dehydrogenase-family-protein	gnl|CDD|235824	PRK06545, PRK06545, prephenate dehydrogenase; Validated.	1.80063e-88
NC_014666.1|WP_071587947.1|3544082_3545495_+|ribosome-biogenesis-GTPase-Der	gnl|CDD|179525	PRK03003, PRK03003, GTP-binding protein Der; Reviewed.	0
NC_014666.1|WP_041259330.1|3549743_3550805_+|C40-family-peptidase	gnl|CDD|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	4.55831e-31
NC_014666.1|WP_013424085.1|3555496_3556000_+|small-basic-family-protein	gnl|CDD|377739	pfam06947, DUF1290, Protein of unknown function (DUF1290). This family consists of several bacterial small basic proteins of around 100 residues in length. The function of this family is unknown.	6.71116e-36
NC_014666.1|WP_083819734.1|3556933_3557314_+|glycine-cleavage-system-protein-GcvH	gnl|CDD|234918	PRK01202, PRK01202, glycine cleavage system protein GcvH.	8.61219e-71
NC_014666.1|WP_157735426.1|3558573_3559278_+|MerR-family-transcriptional-regulator	gnl|CDD|133378	cd00592, HTH_MerR-like, Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators. Helix-turn-helix (HTH) MerR-like transcription regulator, N-terminal domain. The MerR family transcription regulators have been shown to mediate responses to stress including exposure to heavy metals, drugs, or oxygen radicals in eubacterial and some archaeal species. They regulate transcription of multidrug/metal ion transporter genes and oxidative stress regulons by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	1.58367e-14
NC_014666.1|WP_083819732.1|3538191_3539130_+|segregation/condensation-protein-A	gnl|CDD|224273	COG1354, scpA, Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair].	3.20643e-51
NC_014666.1|WP_041260817.1|3557858_3558410_+|FHA-domain-containing-protein	gnl|CDD|238017	cd00060, FHA, Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. Members of the FHA family include: Dun1, Rad53, Cds1, Mek1, KAPP(kinase-associated protein phosphatase),and Ki-67 (a human nuclear protein related to cell proliferation).	2.07489e-21
NC_014666.1|WP_049807180.1|3540158_3540881_+|pseudouridine-synthase	gnl|CDD|224108	COG1187, RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis].	2.0001e-88

Protein sequences

>NC_014666.1|WP_013424078.1|3545709_3546321_-|hypothetical-protein
MAGDRAPDDWVYVVTDIETDGPWPGPNSMRSFASVAVSVDGTRHGQFEAVLEQLPGAAPNPHTLAWFQAQPEAWAAATTGQRPVPAVMAEYVAWVQALPARRMFAASPLAFDGCWLDYYLRRFTRYGLIHGPYETDWLFTGPGLCLRSYAAAVTGLPVASVGGATLPSSWYGDVPHTHRALDDALGYANLLVALTNQPRPAGP
>NC_014666.1|WP_071587947.1|3544082_3545495_+|ribosome-biogenesis-GTPase-Der
MSPRDDDRASKDSGASQDSPDPTTGTVAGGQPVLAVVGRPNVGKSTLVNRILGRRAAVVEDVPGVTRDRVAYDANWSGRRFTLVDTGGWEPDARGLAGRVSAQAQRALATADAVLFVVDATVGATDADEAVARVLHRSGRPVVLAANKVDDQRLESDTAALWGLGLGEPYPVSALHGRGSGDLLDAVLAALPEAPPERFDEEDGPRRVALVGRPNVGKSSMLNRLAGEERALVHDVAGTTRDPVDELVTVGGEQWLFIDTAGLRRRVGQSSGAEYYSSLRTAAAIEAAEVAIVLLDAGETLTEQDQRVVQMVVDAGRALVLAFNKWDLLDEDRRLTLEKEISRDLARVAWAPRVNVSALTGRATDRLAPALHTSLDSWGTRIPTGRLNQWLGEVVAATPPPPRGGKIPKVLFATQAGVRPPRFVVFATAFLEPGYRRFLERRLREDFGFVGTPLEISIRVREREDRRGRH
>NC_014666.1|WP_013424076.1|3543068_3543902_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MTGPDPEPTSAVVDPAPAPVEAASAPVEPAPAPVEPAPAAVEPAPASLPAETTAKQPLHRGAESKPYNDILHRTLKPPVRVLLNRLVMRIRLEGVENIPRDEPLIFAGNHSSWLDGPLVVIEAPRTVRCLTKVEMYKGVLGWLLRLVGQIPIDRGKADRVALHTALDELGRGKAIGVFPEGTRGSGEMAAVQHGIAYLAVHGRCRVLPVACLDTGDALPKGARWPKRSVQVRVVFGAPFAVEIPANPRSRKALAAVAEDIRVHLADHLATARASETV
>NC_014666.1|WP_083819554.1|3542289_3543072_+|(d)CMP-kinase
MLSGRRTRVEHDHGSGEKSGGGRGGPGLVVAVDGPGGSGKSTAAKAIARRLGLRYLDTGAMYRAVTQLALEQRIDIEDAAAVAELAERAVLTSGTDPDAPTIAVNQVRVDAEIRTRAVTNAVSAVSAVAVVRSRLVSQQQQIITEAVDTAGGIVVEGRDIGSVVAPDAPVKVFLTASTEVRALRRSRELGEKGVDDVARTLAELGRRDELDSTRKVDPLQAAPDAIVVDSSGMTVDEVVDEVLRHIAAAGFAAAIPGSAP
>NC_014666.1|WP_157735424.1|3540997_3542137_+|prephenate-dehydrogenase/arogenate-dehydrogenase-family-protein
MRPRAVTWADVTPVPVPSPDLPRRVGIVGSGLIGTSIGLALRRAGVEVLLRDTDPEQVKLAEALGAGSLWQGERVEHAVVAVPPHAVAAELRALQQAGITDSASDVASVKSRPIAEAVVAGCDLTTWCPAHPIAGRERGGAASAQADLFAERTWVLCPTVHTTSAAVAATEALALACGALPVRTTPDRHDEAMAALSHLPQVVSSLLAAATPHLRPGELALAGQGFRDSTRLADSDPALWSSILEGNRGPVAAQARRVAAELGALADALDHASEASVGKVVTDLMDRGRAGRTLLPSKPGPAAARPWGWVGVVLDDRPGQLAALLTTMGDWRVNLEDIGPFEHSLQAPAGVIELAVAPDVAADLVDRLNAAGWCAYRRS
>NC_014666.1|WP_049807180.1|3540158_3540881_+|pseudouridine-synthase
MRLQKVLASAGVGSRRHNEELIDAGRVRVDGKVVREQGRRVDPETAVIEVDGERVVTRTGLVHLALNKPRGVVSTMSDPEDRPTISDLLTEFGASAGLFHVGRLDVDSEGLLLVTNNGDLAHRLTHPSYQVPKTYQVQINGPLRKETMRRLHTRVELSDGPVRVDSARIIDQVGSQILLEIVLHEGRNRIVRRMMEEVGHPVVRLLRTEFGAVHLGTLRSGRARHLTLHEVGALHSMVGL
>NC_014666.1|WP_157735423.1|3539243_3539885_+|SMC-Scp-complex-subunit-ScpB
MAERVEPEPEAVVGDAHDAEPEAEAEPLPEPENRPPLVALVEAVLMVAEKPVGVAELATGLAAHALDVERVLAELAAQYRADGRGFDLRHVGGGWRFYTAEECAPWVERFVLAGQMSKLSQAALETLAVVAYQQPVSRGRISAVRGVSADGVIRTLTARGLVEEATTDPETGAILYRTTDYFLERLGLRGLDELPPLAPLLPGFDDIEDLIAP
>NC_014666.1|WP_083819732.1|3538191_3539130_+|segregation/condensation-protein-A
MSAGPASGGAGALPADALPLTARSGRSEAFLVELDNFSGPFDLLLSLIAKHKMDVTEVALAKVTDEFVAHLRRLGERFDLGQATEFLVIAATLLDLKAARLLPTSGGDGEDEDLALLEARDLLFARLLQYKAYKEAAAIFQTLMTLESRFTPRGVALEPRYAAALPEVQITVGPSELAAMAARLREPVLPPVVAVDHVHAPRVSVREHMLVLIQRLRELGAASFRSLCVGCRETIEVVARFLALLELFREGRISFEQDTPLGELIVRWSEEQPEGTDIGGGLTPVADLPARSDFDDDLSSDDDADADEEAGR
>NC_014666.1|WP_157734940.1|3537240_3537942_+|hypothetical-protein
MDLLVGCLVLHGPQSRYLFLGRLAGWSGTSIDVPDLPIGRQWLLALVDLYGRSAAGLAHLPDAARDLGVDEETATALAALVARWEACAAAPHQQAPHQQAPHQQGPHQQATAAWVPADHAARSGPWPAATAAARPRVAAEGPLTEEEVAALTSAFADQTAAGQLLSDAGLRAERQPSWRVNTAEEFWVEVAALVRDGILPDGRARILTAAASRLPDHPVLARDPGDRAARSAD
>NC_014666.1|WP_013424069.1|3532969_3537133_+|tetratricopeptide-repeat-protein
MTPAGVPARGQPVDPRDLADALWLAAVAADLPPPAPRAARGDDETERSGPDPASSRLTGRPGREADRASPRDGSPGSPAGSAPAVDERAGDQSSESSTRDRGTSTRPRSAGWASARRRRGGWSEPAPPTLESLVTQWREVHQALNVARQWVPSSRDVVLDDEATARHLADGHWRPVYRPVPERRWSLTLVVDDNWTMSVWQSLVPRLVAMLERLGVFEDVRLCFLDTDVDDARDLRLRGSRRAPNGFSPSRLLEPPGRRVIWVLTDGMGTAWRRGLAGRAVWTWARRLPVALLGAVPRSTLRYTGLEENQGLRPVTDGQAIAVPLLEPHPTSLARWAARLTQDGAGGGELPTVLVSPAPPEPGPPTGDGGDPARGPALPRRQVDAFRSAASPVAFDLATHLAAAPITRSTLRPLLRMVEGPPGRTTAALSELFAHGLLYPVAGSSADETDIAYEFAPGLRERLLPYCSRAETARVLRTVSADLGPKVTAVRHLAAALLDPDGVPIPAVTPETEDFVAVEAVAFAALSGPYLPRARRLQAALAQPTPAPIGRVPAVWGRVPPRNPRFTGREELLEEVRVNLRQRSAAPDVPAAITGMVGVGKTQVATEYTYRFSSDYDIVWWISAEHSTLIAASLMDLGRELNMDVGTEADSAVRRVVDALRAGQPYSRWLLVFDNANEIEMVRNYFPTGTAGDILIVARNTAWLRLARCVEVGPFTRSESIEMLRLDDRLDEGIDLPVADADRLAAALGDLPLAVDQASIWCRETGMPVGEYLRLFEDRNVNLAGSLPAYDISIDVAWSLALDRIEQSSPSACRIAQLVAFLAPLPIRRKFLFDGLAALSMPEFDAVPLRPVEMARAVGDLNRYGLTRVGPGDDTILMQTLVQPVVVNRMPPGERDLVRGAARALLAVGDPGTPDDPAAWPLYAELYPHLLATDAADSGDPRVRETLVNEVIYLFRWGDHERSLELATQVHETWEQTIGEEAPEMVRLAGWLGRLHHANGHYDEAARINSRALELCARVHGDAHPETLLAMGNRVADLVAAGDFHGCLELADERSRRATEALGPRDPATLVAAHDVGAALRLVGRYDEARRADQETWSLRAAVLGENNLDTLRTVLGLTIGQRETGDYVGAPRRQERIVERLVEAVGGRRDHIDVLTAQNQLAVALRKAGLHAEALRVARDVRTQLDRRYGRDHPRTIAASLALSAALSADLRNTGNLSEARELAEEALGRCERAFGPPHPHTRAAAVSLALAVRHCGDVARAVELDTVSLDVLADRLGPDHPYTLAAAANLASDLFAAGEFERALERDQDTIVRCRRTLGGDHPETLLITINLAQDLRALDRAEEGVRLNGATVERLTRVLGAQHQAVKNATAWMRSDFDIDPEQL
>NC_014666.1|WP_083819733.1|3548305_3549127_+|class-F-sortase
MIRSAEAPSGRALPPPAPVPTSPSGPPSATPSALPPPPVVTDPVRLRIPAIALDAPVIGLGLDPQGAIDVPTQWGDVGWYKPGVAPGAVGPAVLVGHYDSKTGPAVFYRLGSVLPGDQLVVVGASGASVTFVVDRLQEVSKATFPTQEVYGPVTRPEIRVITCDGAFDEHTHHYVDNLVVYGHAISVPASVAPAPAAAAPSAAVAAPRPAAATAAVRTGAPAAGSPAAPPVAVPPVALSPATPSPSTPRAAPPAAAVVSGAPPTPRLTVTPSQ
>NC_014666.1|WP_041259330.1|3549743_3550805_+|C40-family-peptidase
MSRRGMAWLPDDWDELVRGRHRTGGAPEEARRRSGPGSRRAGTIAAFTTGTLAVSTAAFAATVPSAPEQPTTIDPSSQSQSTPFASNALAAALGGGDTVIPTSHGSSGLAGALANSDPAFTNLTLSADKTTVAPNSPVVLTVKATEAMSGAPLANEQVQIVVVDGPKWQTTAALTTDGNGTASISARLLSTTTITAVFDGGSTLRPSVAGATTITISSGRAASSYLNNAIPSVIPGSTIGEKAVYLASLQKGKPYVYGATGPYSFDCSGLVQYVFRQLGRSLPRTAEAQYEASVHVAQSAKQPGDLIFFGTPGSIYHVGIYAGNGYMWAAPETGGVVSLRPIYSSTYHVGRIM
>NC_014666.1|WP_013424082.1|3551179_3551875_+|CDP-alcohol-phosphatidyltransferase-family-protein
MTSAPVPSGDGPGGASAPPGGRSPGGQPVASDRILTIPNLLSTLRLVGVPVFLWVALGPRADWVALGILMFAGVSDYLDGRLARALNQTSRLGALLDPLADRLYILATIVALTVRGNIPWWLTAIIIGRDVFLTLLLVPMRRLGLGTALPVHYLGKAATFNLLYAFPLLLLADGHGWLSTVARPLGWAFAIWGTAMYWWAGLLYAFQVAGIARDRHRGASGGRPAPAGGSP
>NC_014666.1|WP_041260815.1|3551886_3554394_+|NTP-transferase-domain-containing-protein
MAGGEGTRLRPLTANAPKPLLPVVNRPIMEHVLRLLKRHGFDETVVTVQFLAAMVRTYFGDGDELGMHLSYATESTPLGTAGSVKNAEAALRDEQFLVISGDALTDIDLTALVAEHRKNGALVTVALKSVPDPLEFGIVIAGEDGRISRFLEKPTWGQVFSDTVNTGIYVMEPEVFDHVPAGEPVDWSADVFPRLVAAGAPVFGHVVSGYWEDVGTIASFQRVQADVLNQQVDVEIGGFEVSPGVWIGQDTDVHPDAILKGPLVVGDYSKVEAGAELREFTVVGSNVVIKKGAFLHRALVGDNALIGPRTNLRGCVIGKGTDVRRAARVEEGAVVAEACVVEEEAFISHDVRIYPYKTIEAGAVVNTSVIWESRGQRSLFGPRGVSGLVNAEITPELAVRLAAAYATTLPKGATVTTARDGTRAARALKRAVISALTTSAIDVRDLEVAAMPVTRFDVRTSDAAGGIMIHNTEGDPERIDIVILDADGDDLSPAAQRKLDRVFSRQEFRRAFPGEIGDLRLPARTADRYTQDLLDRIDMSGVAEAALKVVIDPSGGAASLVLPTLLGRLGVDVLTVNGRLDDTAITHTEAQRVEAVRRLGDLVASSRAAFGVRFDQVGERITIVDERGDLIDDDRALLVFLDLVAAENRGATVAVPVTTTLVAEQITRFHGLSVRRTSLSAADLPRVARDPLVVFAADGRGGFVVPEFGAAIDGFAAFVRLLALVARTRLTLSAIDARIPPVAVVRRSVPTPWAAKGTVMRRIVESVDVAAGHVIDTTDGVRVVRPDGAWALVLPDPAEAVTHLWAEAGSRDEACALLADWAAIVEADHRDTPAR
>NC_014666.1|WP_157734941.1|3554529_3555489_+|DUF881-domain-containing-protein
MPDVPSPGSAPRVSGRLPGPLAAVAAQALDPAYPRARVAGPRSGGQRPGPAGGRPPGAAGRRGRTGVTGAGPLGRRAPERSPARLAAVAVAVGLLLAVAGVTQRAGAPGRARLDAALAAERDRGEAAVAVKTAEARGLRSTVAAARSALARDTATQRATADALGVLEPAAGATVATGPGLRVQIADAAGGDADAGPRGSGQRGAGGVTDQDLAAIVNALWAAHATAIAIDGVRLSGTSPIRTAGGAILVDFQPVVSPYRLDAIGVPAALLAAFFGSGPGRLLADGDLAGARLVAATTARVVTVPAAPVTTPRLARRLGQ
>NC_014666.1|WP_013424085.1|3555496_3556000_+|small-basic-family-protein
MTRPDDAAGPTPGGPVPAGPAAGPTSPPPDPPRPGSAAAVPGGPGLTWWRRAGASSWLVPVLALVAGLVAGLLVRPTAPGWLAPYLPVAVVAALDALAGGLRAALERVFDDLVFVVSFLTNAGVAVALVAVGEQLGVGGALTTGVVVVFGIRIFTNATALRRHLFGV
>NC_014666.1|WP_157735425.1|3556157_3556796_+|DUF881-domain-containing-protein
MLAASGFAIPVAISAAGRTAPAGTTTAGLVDQLATAGAEDRRLSGQLDQLQGERATLAAAAPDPSVLATATARASTLAVLAGTVPVVGPGITMTVTDPRGNVGADVFVDALQELRDAGAEAIELAGVRLVAESYVVDRPGGGLLVDGVAARAPYQLAVVGDPHTLAEAMRFPGGVLDTVAARDGAEARVTETDRVEIRAVRGTPSPASRPAG
>NC_014666.1|WP_083819734.1|3556933_3557314_+|glycine-cleavage-system-protein-GcvH
MYPEDLKYSREHEWVRLTGETLRVGITSYAQEALGDIVYVSLPEVGAQVRAGEPFGEVESTKSVSDVYAPASGEVVARNEALDGSPELVNSDPYGEGWLIEVTVADKSALDELLDAAGYQAHVQST
>NC_014666.1|WP_041260817.1|3557858_3558410_+|FHA-domain-containing-protein
MFCTKCGQHNPPDALYCARCGSPLVRPGEPVAPERPLEPQTSTLNLATAALHRLDPDQAEEAGEREAVAAVDALPPGSALLVVKRGPNAGSRFLLDADLTTAGRHPESDIFLDDVTVSRRHAEFLRSPYTKGFTVRDVGSLNGTYLNRERIDAADLSSGDEVQIGKFRLVFLTGSPYPGGGPL
>NC_014666.1|WP_157735426.1|3558573_3559278_+|MerR-family-transcriptional-regulator
MNIGEVLDRLRVDYADITLSKIRYLEAEGLVEPARTSANYRKYSAGDVARLAYVLHAQRERYLPLRVIKDELAAMDRGEAPPAAPTGPRAVPSTPPATGLDVLLGAERVRLSRRELLAASGLDEEALAELERHGLLRAVSGGGYYDADALVVARTVGLLAAHGVQARHLRAARAAADREAGLIEAAVAPLRAPRSAGATAGDDDLPRDSVDELALLLVRLHAALLRARLGSGPR

Crispr_ID: NC_014666_12

• CRISPR_ID: NC_014666_12
• CRISPR_location: 4114581-4114723
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_014666_12

Consensus_repeat	Method
GCCGAGCTGCACGGTCAGGCATTGGCGGCCGCTCGGGTGATTGATGA	CRISPRCasFinder

spacers of NC_014666_12

>12.1|4114628|49|NC_014666|CRISPRCasFinder
ACCGCGGGCCCAGGCGCGGGTCCTGACCGTCCTGGCACCGCACCTTCCG

CRISPR arrays and Neighbor proteins around NC_014666_12

CRISPR arrays

The CRISPR arrays of NC_014666_12

>merge|NC_014666|12|4114581-4114723|CRISPRCasFinder
GCCGAGCTGCACGGTCAGGCATTGGCGGCCGCTCGGGTGATTGATGAACCGCGGGCCCAGGCGCGGGTCCTGACCGTCCTGGCACCGCACCTTCCGGCCGAGCTGCACGGTCAGGCGTTGGCGGCCGCTCGGGTGATTGATGA

>NC_014666|12|10|4114581-4114723|CRISPRCasFinder
GCCGAGCTGCACGGTCAGGCATTGGCGGCCGCTCGGGTGATTGATGA	ACCGCGGGCCCAGGCGCGGGTCCTGACCGTCCTGGCACCGCACCTTCCG
GCCGAGCTGCACGGTCAGGCGTTGGCGGCCGCTCGGGTGATTGATGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_014666.1|WP_013424472.1|4099650_4100139_+|DinB-family-protein	unknown	unknown	gnl|CDD|368218
NC_014666.1|WP_013424487.1|4124205_4124634_-|hypothetical-protein	unknown	unknown	gnl|CDD|223021
NC_014666.1|WP_013424478.1|4109103_4109748_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228
NC_014666.1|WP_013424490.1|4128035_4128791_+|CHAP-domain-containing-protein	unknown	unknown	gnl|CDD|366659
NC_014666.1|WP_157734961.1|4110726_4110954_-|hypothetical-protein	unknown	unknown	gnl|CDD|214567
NC_014666.1|WP_013424471.1|4094581_4099495_+|diguanylate-cyclase	unknown	unknown	gnl|CDD|226415
NC_014666.1|WP_157734964.1|4130818_4131577_-|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|378820
NC_014666.1|WP_083819576.1|4103779_4104721_+|endo-alpha-1,4-polygalactosaminidase	unknown	unknown	gnl|CDD|377061
NC_014666.1|WP_157734963.1|4129550_4130726_+|hypothetical-protein	unknown	unknown	unknown
NC_014666.1|WP_013424489.1|4127054_4127729_-|hypothetical-protein	unknown	unknown	unknown
NC_014666.1|WP_041259410.1|4120692_4122492_-|hypothetical-protein	unknown	unknown	gnl|CDD|373106
NC_014666.1|WP_013424483.1|4118047_4119109_-|cation-transporter	unknown	unknown	gnl|CDD|223131
NC_014666.1|WP_013424473.1|4100661_4103154_+|molecular-chaperone-DnaK	unknown	unknown	gnl|CDD|234715
NC_014666.1|WP_013424484.1|4119390_4120659_+|cytochrome-P450	unknown	unknown	gnl|CDD|225035
NC_014666.1|WP_013424479.1|4109758_4110589_+|methyltransferase	unknown	unknown	gnl|CDD|182918
NC_014666.1|WP_013424488.1|4124756_4126829_-|endonuclease	unknown	unknown	gnl|CDD|224777
NC_014666.1|WP_013424482.1|4117122_4117965_-|slipin-family-protein	unknown	unknown	gnl|CDD|259808
NC_014666.1|WP_013424477.1|4107397_4108930_-|MFS-transporter	unknown	unknown	gnl|CDD|129794
NC_014666.1|WP_013424476.1|4106373_4107249_+|LLM-class-F420-dependent-oxidoreductase	unknown	unknown	gnl|CDD|274680
NC_014666.1|WP_157735446.1|4105215_4106163_+|glycosyl-hydrolase	unknown	unknown	gnl|CDD|371727

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_014666.1|WP_013424472.1|4099650_4100139_+|DinB-family-protein	gnl|CDD|368218	pfam04978, DUF664, Protein of unknown function (DUF664). This family is commonly found in Streptomyces coelicolor and is of unknown function. These proteins contain several conserved histidines at their N-terminus that may form a metal binding site.	8.52493e-41
NC_014666.1|WP_013424487.1|4124205_4124634_-|hypothetical-protein	gnl|CDD|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	0.00163072
NC_014666.1|WP_013424478.1|4109103_4109748_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	6.40326e-14
NC_014666.1|WP_013424490.1|4128035_4128791_+|CHAP-domain-containing-protein	gnl|CDD|366659	pfam01471, PG_binding_1, Putative peptidoglycan binding domain. This domain is composed of three alpha helices. This domain is found at the N or C-terminus of a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. This family is found N-terminal to the catalytic domain of matrixins. The domain is found to bind peptidoglycan experimentally.	3.81617e-09
NC_014666.1|WP_157734961.1|4110726_4110954_-|hypothetical-protein	gnl|CDD|214567	smart00220, S_TKc, Serine/Threonine protein kinases, catalytic domain. Phosphotransferases. Serine or threonine-specific kinase subfamily.	1.71985e-05
NC_014666.1|WP_013424471.1|4094581_4099495_+|diguanylate-cyclase	gnl|CDD|226415	COG3899, COG3899, Predicted ATPase [General function prediction only].	4.80132e-67
NC_014666.1|WP_157734964.1|4130818_4131577_-|alpha/beta-fold-hydrolase	gnl|CDD|378820	pfam12146, Hydrolase_4, Serine aminopeptidase, S33. This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.	1.21707e-14
NC_014666.1|WP_083819576.1|4103779_4104721_+|endo-alpha-1,4-polygalactosaminidase	gnl|CDD|377061	pfam03537, Glyco_hydro_114, Glycoside-hydrolase family GH114. This family is recognized as a glycosyl-hydrolase family, number 114. It is endo-alpha-1,4-polygalactosaminidase, a rare enzyme. It is proposed to be TIM-barrel, the most common structure amongst the catalytic domains of glycosyl-hydrolases.	7.47678e-57
NC_014666.1|WP_041259410.1|4120692_4122492_-|hypothetical-protein	gnl|CDD|373106	pfam14517, Tachylectin, Tachylectin. This family of lectins binds N-acetylglucosamine and N-acetylgalactosamine and may be involved in innate immunity. It has a five-bladed beta-propeller structure with five carbohydrate-binding sites, one per beta sheet.	5.89143e-16
NC_014666.1|WP_013424483.1|4118047_4119109_-|cation-transporter	gnl|CDD|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	1.01186e-74
NC_014666.1|WP_013424473.1|4100661_4103154_+|molecular-chaperone-DnaK	gnl|CDD|234715	PRK00290, dnaK, molecular chaperone DnaK; Provisional.	0
NC_014666.1|WP_013424484.1|4119390_4120659_+|cytochrome-P450	gnl|CDD|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	9.89475e-36
NC_014666.1|WP_013424479.1|4109758_4110589_+|methyltransferase	gnl|CDD|182918	PRK11036, PRK11036, tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM.	4.33629e-28
NC_014666.1|WP_013424488.1|4124756_4126829_-|endonuclease	gnl|CDD|224777	COG1864, NUC1, DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism].	6.83608e-61
NC_014666.1|WP_013424482.1|4117122_4117965_-|slipin-family-protein	gnl|CDD|259808	cd08826, SPFH_eoslipins_u1, Uncharacterized prokaryotic subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily. This model summarizes a subgroup of the stomatin-like protein family (SLPs or slipins) that is found in bacteria and archaebacteria. The conserved domain common to the SPFH superfamily has also been referred to as the Band 7 domain. Individual proteins of the SPFH superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Bacterial and archaebacterial SLPs remain uncharacterized. This subgroup contains PH1511 from the hyperthermophilic archaeon Pyrococcus horikoshi.	1.20238e-92
NC_014666.1|WP_013424477.1|4107397_4108930_-|MFS-transporter	gnl|CDD|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.31754e-52
NC_014666.1|WP_013424476.1|4106373_4107249_+|LLM-class-F420-dependent-oxidoreductase	gnl|CDD|274680	TIGR03619, F420_Rv2161c, probable F420-dependent oxidoreductase, Rv2161c family. Coenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H, Rhodopseudomonas palustris HaA2, and others. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxygenanases (pfam00296), that appear only in F420-positive genomes and are likely to be F420-dependent. This model describes a domain found in a distinctive subset of bacterial luciferase homologs, found only in F420-biosynthesizing members of the Actinobacteria. [Unknown function, Enzymes of unknown specificity].	2.67195e-82
NC_014666.1|WP_157735446.1|4105215_4106163_+|glycosyl-hydrolase	gnl|CDD|371727	pfam11790, Glyco_hydro_cc, Glycosyl hydrolase catalytic core. This family is probably a glycosyl hydrolase, and is conserved in fungi and some Proteobacteria. The pombe member is annotated as being from IPR013781.	2.08904e-68

Protein sequences

>NC_014666.1|WP_157734961.1|4110726_4110954_-|hypothetical-protein
MAAVAPLDDLDPRAIGPYVLLGRLGDGGMGSVYLGRRADAAPTGDAGPELVAVKVIRAVWQAALPTVDPRPVPIS
>NC_014666.1|WP_013424479.1|4109758_4110589_+|methyltransferase
MTAPGARPNDNSWVRGAVDRALAPGYQAHTATLRGAVRQRLVTRALLTHLPTPPGRILDVGGGEGTQARALARLGYEVTICDPDPEMLRQADERLSGADAAVRDRITLVHGDGHDAASLVGGGWDGVLCHGVLMYLTDPAALLHVLADVTGAGGVISVVGKNATALALRAGLQGRWRDTLSLLDEEPRAAAGTVTEIGNLGVPSRGDDPHQIRDLLSAAGTEPLAWYGIRVLTDHLGDTPPGPDLDTVVEAEWRAGERDPYRQVARLYHLIHRRRP
>NC_014666.1|WP_013424478.1|4109103_4109748_+|TetR/AcrR-family-transcriptional-regulator
MGRPPGFDRREVLAAVEREFRKNGFDGTSLDDISAATGLGRGSLYAAFGDKHALFLAALGDYCDQDEASGAAALAGPDETAMRRLRAYFVDSVDRQLNDPEQLACMASRFTVELAGRDQDATARLRQGFEAQRAALAGCLRAAQRNGDLDPAADPVTLATLLVVDFRGIGSLIGIGVDRAELVALVDAALAGLPVPPLSAAASSPPGHVLDRPS
>NC_014666.1|WP_013424477.1|4107397_4108930_-|MFS-transporter
MTQQDAQPDRAGPDLGAVPPIPSQRRADAGARPVSPALLLAILSIASFLAQLDVWVTNVGLPAIGHGTHAGSLADLSWVLNGYAIVYAALLVPAGRLVDRFGRKGGFLLGLTVFAVASIGAGLSGDIWVLIGFRVLQAAGAALLTPASLGLVLLTAPPAKIGTYVKIWFTTGALSAASGPVLGGLLVEASWRWLFLVNIPVAAAAIALGARYLPSSRDAGDHLPDLRGGGLLIVAIGALALGLVKAPDWGWSSGRVVVAFVLAAVALALFLASSARHPAPVVTLSLFRDRVFTTANLVATVAFMAFGIELLSTILWLQGHWHYSVIRTGLASTPGPVMFAVGSAVAETLQARTRLRAGRIAVAGALLAAVGTIMLTQLVTDEPRFVAAFLPTWVVLGLGYGLAVPTAITRATVGLPPKDSATGSAIVTMATQLGSVIGISVLVAILGRASGAASHAVFQHAWYVSAGALVVAAVASFGLDSRATAPSRPDLPPARTSPADAGDPEAAARL
>NC_014666.1|WP_013424476.1|4106373_4107249_+|LLM-class-F420-dependent-oxidoreductase
MQIGVVYPQIELRGDPVAVRRIGTAVEGLGFDHLLAYDHVLGAVHADRSPPLTGPYTEHDPFHDPLVMFAHLAAITEHIEFATGILILPQRQTALVARQAADVDLFSGGRLRLGVAVGWSQVEYEALGQDFQTRGARQEEQIGLLRRLFTEPVVDFSGRFDRIDRAALIPKPTRSIPIWLGGSGDAALGRAARLGDGFIFSGSRGIERALGGWARLRDLLIEAGQPVEGFGAEYVVLAQGDLGTAVAEIDAWRAAGGTHVSVATMGRGLDSADGHLDVLTTLASALNLTAR
>NC_014666.1|WP_157735446.1|4105215_4106163_+|glycosyl-hydrolase
MAGSTSAPGSAQPSTSGAATTPTATGPSGTPTSSLAAAPPPPATPPPSATPSPRPTVTVAPPRPPVAGSARKGVSVWSFDGLQKALSDVGVSWFYNWAATPGGVTPPAGTRFVPMIWGAGSVNPATLAQAAAAGDTLLGFNEPDLGSQANMTVDQALDLWPQLQATGRQLGSPAVAAGGADPGGWLDRFMTGARQRGYRVDFIALHWYGGDFDATRAVGQLRSYLQAVYDRYHLPIWLTEYALLDFSGGSARAPSTQQQAEFVTASTTMLESLPFVGRYAWFALPATPGSLTGLYDPQGNPNAAGVAYRQARAPA
>NC_014666.1|WP_083819576.1|4103779_4104721_+|endo-alpha-1,4-polygalactosaminidase
MIDRLARRAVVRVTAVALAALCLCVTTSRCSAGGPAPDREATAGAQVSSVAASSTGPASAVPAPPTGPAGDQRARVVLPPVGAAFDYQLGGAYTPPGGVGVVSRDRTAKPVAGLYNICYINAFQAQPDALAWWQARHPELLLRRGDHGLVIDRDWGEALLDTSTAARRAALAAVVAVWVDDCAASGFQAVEPDNLDSFERAEGLLTQADNAAFAQLVARRAHADGLAVGQKNTAELLGQRRTVGFDFAVTEECGTYGECAGFADAYEDRVYDVEYSDSGLAKACGGWMTRISIVRRDRDVVPAGSDGYVDRTC
>NC_014666.1|WP_013424473.1|4100661_4103154_+|molecular-chaperone-DnaK
MARAVGIDLGTTNSVVSVLEGGEPTVIANAEGSRTTPSVVAFAKNGEVLVGEVAKRQAVTNVERTIRSVKRHMGTDWKMKVDNKDFTPQQISAFILQKLKRDAEAYLGETVTDAVITVPAYFDDAQRQATTEAGTIAGLNVMRIVNEPTAAALAYCLVRARWVAVDEALTVLVFDLGGGSFDVSLVEIGDGVVDVKATHGDTHLGGDDWDQRMTDHLIKTFQGQHGVDLAKDKMALQRLREAAEKAKIELSQSTQTTINLPYITASAEGPLHLDVSLTRAEFQRMTQDLIDRCKIPFQQAVKDAGIKVAQIDHVLLVGGSTRTPGVVDLVRELSGGREPVRSVNPDEVVAVGASVQAGVLKGEVRDVLLLDVTPLSLGIETKGGIMTKLIERNTTIPTKRSEIFTTGDDVSGRPVPNRPPPKGGTAAEGPPDGSRPGGGQPSMIFEVFQGEREMAAYNKKLGMFELTGLPPAPRGVPQIEVTFDIDANGIVHVSAKDLGTQKEQSMTITGGSALPKDDIEKMVRDAEQYAEEDKQRREEAETRNQGESLVHSTERFLAENGDKVEATLKADVEKKLAALRLASARFDADAVATAMGALQKASAVMGRSMLARTEADRAVNAGQNRADGRAGSEPRTGNGNDRDLKEAASASDQSRDWDFFISYTAYDIKWAEWIAWQLEQAGYTVIIQSWHMVPGANYHVMMDEAIRRSRRTVAVLSDRYLQSVYGTTEWQAAHAGDPQGLRRKLVPIRVSDCDRPGILRSVISFDLFEVSEAVARDRLLKGIRAAVEGHDRPVKAPGFPGAPTSIAALIPDITPHGQTVRHKRPDFPTA
>NC_014666.1|WP_013424472.1|4099650_4100139_+|DinB-family-protein
MFIWPRMTAGPERLMLESVLDRNRQALIDTARGLSEADARRRLVVSLTTPIGLIKHAATAERIWFQRTLLGLDESACDGYATGDDGSFLVAEGETLADVIAEFERASERSRVIAADFELDDTKAHPGAGDVSLRFVYLLLIEDFARHAGHGDILREQITAAR
>NC_014666.1|WP_013424471.1|4094581_4099495_+|diguanylate-cyclase
MGSEREMQGPDPPDPVVTEVLHESERTRVTRVVSRTGSVIKKEFLGPAAQARLLREVEFLKRLRGVEGVAQLASGSEPGPESFLLVDVHGTALSGRTVPVDPVRLLNLAERLARGLAGLHRRGVVHRNINPANIVVDADDAPYLVDFALATSTAPVRPDLLRSTEIVGTVAYLAPEQTGRTARPVDARADLYAVGAMLYELATGAPPFGSADPMQVIHSHLTRVPVPPSATNPLVPAGLSAIIMHLLEKEPDDRYQSAEGLVFDLALLRRGGEVVHPGERDLPARALVPSRLAGRDREIAQIRDAFAAAMEGRCRGLLLGGAAGVGKTTLVDELRSTVANANGWFVAGKFDQYRRDQEYDGVTQAFRALGRLLLAEPEKDLHQVRDALLQALGPNAGLMAMMMPELGALLGVAAAPGDPMTTQARARRNAAEILRVVACRERPLVLFVDDLQWAGRAPLDLVDLVMDSGLRLEGLLLVGAFRDSEVDAAHPLASMVARWGRLPDGPRVLRVGNLAPDGQAALVADLLRLPSGPAADLAGTIAPSTRGNPYETVELLNALGQDGTLTRDTRGWRWEPEVLRRRLAGVDVSALLAARAGVFPSATRAILAAIACLAGRVELDLLEAATGLASDEIGRLLAPALADGFLVLEPANRSSVRFHHDLAQESVIDDLDGDTRRATRLGLARRLAGRDEYSAVAAEQYLLVADTVHAEPERQVMAGLFERAASQARMLSNYGQAERFLAALLRSVDRRDKERLVAAHVDRHAVLYMLGRLEDADEEYQVVIRLRPRSTEGPGVTAVQVSSLINRGRSGEALALGLEALRHLGLAIPARERLEAETDRGLDALYAWIDETTEADDLRRPKITDRSRLDTVRLINRLIPAAFICDRMMSAWLAVTILRIWATDGPDAALIGPAGHAALVTVARRGDYRTGYRMMRRLLAVGRARGYEPELWRARFLYVVGTGHWFEPLEDNVSAARRTLAGLFQAGDLQTACWTYYTLVCDFLDLAPSLADFVAEADEALRFAARTGNGHAEKILRACRDLAGELRGEPTGRPDAAGLAAAEPTVAFHLHLGRAVAAAVLDHSGELERHTDALMPLLSSVESIYHTATVRMLRALALAGRARAARARQRDRALVELEGLVEWLAERAADAPVNFGHMLRLVEAERAWALGDFREAVCTFDLAQREVSARARPWHRALILERAARFYLAHGVDQAAHGLLVAASDQYLAWGATAKVRQLDYAFPLLRAERSGARPNSQPPPQPAHLQPVVTTGTLDLLGIVAASQALSSETSIDGLRVRVVGILSEITGSTGVRLLLRDQETHAWTVPLDEGGTISLEEAGRRKLLPPSVVWYAERTGEPVLIDDAIRDDRFSRDPYLATMDRCSLLAVPIILRDELHAMLLLENRLIRCAFTTDRLEGITLIARQLAVCLDNALVYASLERRVAERTEQLAAANHRLEQLSATDPLTGLANRRQLNEFLNDAWYRAASYGTPLALAMIDIDHFKAYNDFFGHTVGDLCLRRVAACLARCTRDTDLAARYGGEEFVVVMPGADSVTATQIAHRLRTAVEDLAEPHPRTDERIVTVSIGIATTTPGPRDDVAALLEVADAALYLAKNGGRNRVEAGGQHEVPADYRAR
>NC_014666.1|WP_013424482.1|4117122_4117965_-|slipin-family-protein
MIVLLIVVVVVAAVLLLASLRTVQQYQQGLVFRFGRMLPRLRTPGLTVVLPFGIDHLVRVNMRIVAMSVPRQECITRDNVTLTVEAVVYFRVVDPVKAIVNVENYRFAVTEVAQTSLRSVIGRSDLDHLLSDQERVSAELRAVIDEPTEGPWGVKIERVELKDVALPESMKRSMSRQAEAERERRARVITAEGEFQASQMLAQAGRVLAADPSGLQLRLLQTVVEVAAEKNSTLVLPVPVELLRFFDRGETGRLDSVGEPKSDPPSPDGKQHPALQDDSV
>NC_014666.1|WP_013424483.1|4118047_4119109_-|cation-transporter
MDTGQEHERAAHGHGHAHGGHPHEDGHADHPAGRWVRLRHGLLDLIGGHSHDSADQIDDALEADAAGRRALLISLAGLALTAAPQAVVVALSGSVALLGDTLHNVADALTAVPLLIAFTLARRPPTTRFTYGFGRAEDLAGLAVLAMISLSSVLAGWAAIDRLLHPRHIDHLAAVAVAGLVGFVGNEIVARYRIRAGHQIGSAALVADGLHARTDGLTSLAVLLGAAGVALGWHWADPVVGLAITVTILGVLRSAARVLGARLMDAVDPDVVAEARTTLLHTEGIDTVRELRLRWIGHTLRAEADVTVDPNLTLAAAHDVAHAAEAHLLRHIRRLSAATIHTSPALHHATPAL
>NC_014666.1|WP_013424484.1|4119390_4120659_+|cytochrome-P450
MTPHLAGSTGTADSRDHDRPVPSDHPADAVPLFGPRFEQEPAALYREMRARFGPVAPVLLEGGHPAWLVLGYRELVYVTSNPALFARDSRRWNRWPQIPPDWPLLPGVGYLPSVYFAEGVEHRRRAEVVHAALEAVDHLRLRAQCERIADQLIDTFCGRGEADLVADYASVIPLLVVAVLFGLDEADTESLVHDLTEMASGSSDALAAFERVGDLIRRVVARARKRPGNDIPSRMAMHPAGLTDDEMLMDLVVIASAGQLPTSYWTSGTLRLMLVDDRFSTGLSGGRRSVGQALNDVLWEDTPLQNFAGRWAVRTVELGGQRIAAGDLLLLGLAGANADPMVRAGMDRHAAGNHAHLSFSHGEHRCPSPAQAIAEVMVTAAVEVLLDRLPDVTLAVDSDALLWQPSPWTRGLVSLPVRFSPA
>NC_014666.1|WP_041259410.1|4120692_4122492_-|hypothetical-protein
MDDDELKFAEGGIRMLVSLGGLPFAGVPTIAGVIGYVSTVISFLSGGSTVDAVALLKQEVDSLKAEMVQLNSRLDELIENVAIENNRNVQARVDDHLDDIRRLRLRLGDSPGDVDKAVDVANELGVVIDSFLRADFDLWRWTDVVQKNGLRTLELHRFKNAPTLAVYLLGLLSWLAARQVAFDANQRHRLDDDAPRILRHLQAVSVRPEFDKYADGDASVPRSITEHIKWRIRAWVIGLNRLPENRSCRWAFEVRDWMTGRRTLADHFEIITDSDHVLCTVDAASLGPPKTELQMETDAGVDVLNQMAVTLDRVAKTGSAREPVIAPFPDTKVYPPAMFYLIGQNGDLYWYRNVSSSQPGGSTDWAGPTRVSDGWHRFTKAFCGGEGALYGVQPDGTLLWYGHDGYRDGSPTWRGPRTVGSGWNGFREIFSGGEYVVYGIRPDGTLLWHRHNGAANGGDTTTWSGPVPVGTGWQSFAKVFSAGHGVIFTIGADGVLTRHEHRGYSAGTSDWGAQIPIGTGWNVFQEVVAGPDGVLYAFTPDGRILWHCYRGERPPPVFPPGGAGGYDPHIWEGPIEVKRGVLGFRSAFPVMDAPFRAPA
>NC_014666.1|WP_013424487.1|4124205_4124634_-|hypothetical-protein
MSFAPLAAVGTLVFTFVNFLTYIRARQWNGVLTQAIAWVAGIGAIMLAARTDFASDVSFGNSSLGNMDIATQIFLGLIATSILSTVNEFKKAFDNSDSAKKEPLLTGRGPGSDAAGPAGSPPSAQPPPATPAPAPTPKPPAP
>NC_014666.1|WP_013424488.1|4124756_4126829_-|endonuclease
MVSVDSARTERDAALANEQQDALAARAASRLDPRRGNISVLREPGGIARADDPARIAARIARLARHNPDARSVSPAEVGAEEPAATAEAGAVLERIIQTNDLLDVGYLEDGVAAARAVGRIVIRDDRGRTAGYGTGSLVSPELLLTNHHVLSDTRVAASSSVEFDYQDGPDGQPLPLAEFALDPDRFFLADEALDFALVAVRAEPAQLSQFGFNLLVAAEGKAIVGDFVTIIQHPGGGKKQVALRENRIVDVLDLFMHYETDTEPGSSGSPVFNDQWEIVALHHAAVPAPDHGELGGILNEGIRVSRLLAFLRDQTFPTARQALVDRLLDDRVRPAPAAHVLVPAAAPVGPVTVQAPAHEAARIQQSVTLTVPSFDIRLHGGLAGPGLPPVPEPPAPVEEAVRIDPDYTNRVGYDEDFLGSGHRVALPTLHPDQVPLAAVNQLPTGQQPPYVLPYHHFSVVLNRQRRLAFFTAVNIDGATAARLRREPDRWSFDPRVPEDEQTGEQVYRDNPLDRGHLVRRLDPAWGATRAQAKLANDDTFHFTNCTPQHADFNQNQTTWAGLEDYILENADNQDFKVTVFAGPVLADDDEPYRGVLLPRQFWKIAAMVTSAGRLSATGYLLSQADLIRGLEITPAAFSYGAYSTYQVPLARITSLTGLSFDALTASDPLDGLETTDAAREITHPRQLVL
>NC_014666.1|WP_013424489.1|4127054_4127729_-|hypothetical-protein
MRNSVRSIWTEFNEPIEARLDFMYLDIKGLVTTGLGNLIDATSLAHPHTPTPAERTKSHQLAQQLGWRTKVGDAAATPAQIAAEWDQIKARLGQASLGGASFRAFATLRLPDAEIDRLAFEKLTEMEGVLKHRAPFGSFDSFPADAQLGLLSMSWGMGPAFNFPKFQGSVAAGDWATAATRCRFQPDTGGVSLRNDRDQRLFKNAAAVVTKHLNPDTLIWPAVA
>NC_014666.1|WP_013424490.1|4128035_4128791_+|CHAP-domain-containing-protein
MASADDVIRVAAGEIGYHEGPDNDNKYGRWYGMNHAFWCYIFCQWVFAQAGTPLPFRTAYVPYGATWARQNGMWRPSTQSERGDLIIFDWTGTGQAAGSNTHIGIVESHVNGTVQTIEGNRGDSVCRRSYVAGENDIAGTINCQPLFAFHPHPTDNRFQVFPTVQQGIHDLGATGTFPDIAHPVGTLQNALNIVNHKEAPQPGALSPDGVFGGMTANAVRAFQTAESLAADSVVGQRTWATLDHALDRAGR
>NC_014666.1|WP_157734963.1|4129550_4130726_+|hypothetical-protein
MTSFYLAWFGVENVTDSLAYLGCFTGLLMVITATVCILGALGTLDHWYSHRFEISGLLALFGSVTALVANAMLLVATVREGIESVPYFVTWGLLAVASGWSCYVVYHTSVVIPSPKKVAVAASATAVIAMANFGYTQLYQPYHEEPRPILDAKFGSPTLSADRKTFSVPITLSVEVRGNVGVYLVGDQFVVYGRRVTTRSSGHSAPDWRHDSTDGQAELSRWTEMRTEPIEIGRWDLFGSWEDPGVPRSTTRLVQLPVDTPYDQLGVRAEFVSVRRDRVRLEPAFGSSAQYSWQDFRNQRCGSGPGDCVRYRGRVAESNSVARHTRDPRYLTLWWNFGPTLGTVGLESTIARRGDVDRSMSSEESSRLWSRYGLEKVTASATFRSLLDIKH
>NC_014666.1|WP_157734964.1|4130818_4131577_-|alpha/beta-fold-hydrolase
MQLCVTAVPAEEGGVEPGPGPEQRSAARSRVVLVHGLRDEGASFDPVARLLPDLEVLRYDRRGWGACPDWDGVAADLDGHVDDLLRVLAGRPAAVVGHSWGGNVALAAAIRRPDLVEAVGIWETAMPWAEWWPREHRAVIQETIDRAAVTRPGSPRQIRERALAAAEMTLTLHPPFDPGELTVPRVVGYGTASFPHFADGLRAFAAQAGADTVRFAGASHMVHREDPAGFASFVRRVADLRPTTTLVAERVE

Crispr_ID: NC_014666_13

• CRISPR_ID: NC_014666_13
• CRISPR_location: 6076043-6076135
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_014666_13

Consensus_repeat	Method
GAACGGTCTGACACAGGGGGTCGGACCAGT	CRISPRCasFinder

spacers of NC_014666_13

>13.1|6076073|33|NC_014666|CRISPRCasFinder
ACCCGCCTGACCCCACAGCACAACCAACGACGC

CRISPR arrays and Neighbor proteins around NC_014666_13

CRISPR arrays

The CRISPR arrays of NC_014666_13

>merge|NC_014666|13|6076043-6076135|CRISPRCasFinder
GAACGGTCTGACACAGGGGGTCGGACCAGTACCCGCCTGACCCCACAGCACAACCAACGACGCGAACGGCCTGACACAGGGGGTCGGACCAGT

>NC_014666|13|11|6076043-6076135|CRISPRCasFinder
GAACGGTCTGACACAGGGGGTCGGACCAGT	ACCCGCCTGACCCCACAGCACAACCAACGACGC
GAACGGCCTGACACAGGGGGTCGGACCAGT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_014666.1|WP_013426056.1|6089031_6090123_-|hypothetical-protein	unknown	unknown	gnl|CDD|235906
NC_014666.1|WP_013426044.1|6067666_6069196_+|HlyC/CorC-family-transporter	unknown	unknown	gnl|CDD|224173
NC_014666.1|WP_013426037.1|6057387_6057543_+|hypothetical-protein	unknown	unknown	unknown
NC_014666.1|WP_013426036.1|6055326_6056856_+|serine/threonine-protein-phosphatase	unknown	unknown	gnl|CDD|369272
NC_014666.1|WP_041259633.1|6082514_6083540_+|methylmalonyl-Co-A-mutase-associated-GTPase-MeaB	unknown	unknown	gnl|CDD|236515
NC_014666.1|WP_013426038.1|6057671_6058670_-|hypothetical-protein	unknown	unknown	unknown
NC_014666.1|WP_013426051.1|6080178_6082413_+|methylmalonyl-CoA-mutase	unknown	unknown	gnl|CDD|236508
NC_014666.1|WP_013426042.1|6062452_6063991_-|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|235967
NC_014666.1|WP_013426055.1|6086514_6087930_-|HNH-endonuclease	unknown	unknown	gnl|CDD|367155
NC_014666.1|WP_013426053.1|6083544_6084906_-|hypothetical-protein	unknown	unknown	unknown
NC_014666.1|WP_013426057.1|6090199_6090796_+|sulfite-oxidase-like-oxidoreductase	unknown	unknown	gnl|CDD|239027
NC_014666.1|WP_013426041.1|6061471_6062404_+|acyl-CoA-thioesterase-II	unknown	unknown	gnl|CDD|224857
NC_014666.1|WP_013426049.1|6077659_6078121_+|hypothetical-protein	unknown	unknown	unknown
NC_014666.1|WP_013426045.1|6069192_6070278_+|HlyC/CorC-family-transporter	unknown	unknown	gnl|CDD|224173
NC_014666.1|WP_013426050.1|6078223_6080179_+|methylmalonyl-CoA-mutase	unknown	unknown	gnl|CDD|239649
NC_014666.1|WP_013426035.1|6053372_6054914_-|LCP-family-protein	unknown	unknown	gnl|CDD|367673
NC_014666.1|WP_013426046.1|6070672_6073417_+|protein-kinase	unknown	unknown	gnl|CDD|270916
NC_014666.1|WP_013426043.1|6064773_6067158_-|glycosyltransferase	unknown	unknown	gnl|CDD|133043
NC_014666.1|WP_013426048.1|6076182_6077652_+|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|224154
NC_014666.1|WP_013426054.1|6085389_6086163_-|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|379312

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_014666.1|WP_013426056.1|6089031_6090123_-|hypothetical-protein	gnl|CDD|235906	PRK07003, PRK07003, DNA polymerase III subunit gamma/tau.	0.00188021
NC_014666.1|WP_013426044.1|6067666_6069196_+|HlyC/CorC-family-transporter	gnl|CDD|224173	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only].	4.67806e-121
NC_014666.1|WP_013426041.1|6061471_6062404_+|acyl-CoA-thioesterase-II	gnl|CDD|224857	COG1946, TesB, Acyl-CoA thioesterase [Lipid metabolism].	8.40925e-94
NC_014666.1|WP_013426036.1|6055326_6056856_+|serine/threonine-protein-phosphatase	gnl|CDD|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	2.5998e-26
NC_014666.1|WP_013426054.1|6085389_6086163_-|class-I-SAM-dependent-methyltransferase	gnl|CDD|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	2.57392e-09
NC_014666.1|WP_013426043.1|6064773_6067158_-|glycosyltransferase	gnl|CDD|133043	cd06421, CESA_CelA_like, CESA_CelA_like are involved in the elongation of the glucan chain of cellulose. Family of proteins related to Agrobacterium tumefaciens CelA and Gluconacetobacter xylinus BscA. These proteins are involved in the elongation of the glucan chain of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues. They are putative catalytic subunit of cellulose synthase, which is a glycosyltransferase using UDP-glucose as the substrate. The catalytic subunit is an integral membrane protein with 6 transmembrane segments and it is postulated that the protein is anchored in the membrane at the N-terminal end.	1.23108e-32
NC_014666.1|WP_013426042.1|6062452_6063991_-|NAD(P)/FAD-dependent-oxidoreductase	gnl|CDD|235967	PRK07208, PRK07208, hypothetical protein; Provisional.	0
NC_014666.1|WP_013426055.1|6086514_6087930_-|HNH-endonuclease	gnl|CDD|367155	pfam02720, DUF222, Domain of unknown function (DUF222). This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.	1.40763e-16
NC_014666.1|WP_013426048.1|6076182_6077652_+|NAD(P)/FAD-dependent-oxidoreductase	gnl|CDD|224154	COG1233, COG1233, Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism].	1.1514e-76
NC_014666.1|WP_013426057.1|6090199_6090796_+|sulfite-oxidase-like-oxidoreductase	gnl|CDD|239027	cd02109, arch_bact_SO_family_Moco, bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). Common features of all known members of this family are that they contain one single pterin cofactor and part of the coordination of the metal (Mo) is a cysteine ligand of the protein and that they catalyze the transfer of an oxygen to or from a lone pair of electrons on the substrate. The specific function of this subgroup is unknown.	1.9073e-90
NC_014666.1|WP_041259633.1|6082514_6083540_+|methylmalonyl-Co-A-mutase-associated-GTPase-MeaB	gnl|CDD|236515	PRK09435, PRK09435, methylmalonyl Co-A mutase-associated GTPase MeaB.	0
NC_014666.1|WP_013426045.1|6069192_6070278_+|HlyC/CorC-family-transporter	gnl|CDD|224173	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only].	1.9448e-90
NC_014666.1|WP_013426050.1|6078223_6080179_+|methylmalonyl-CoA-mutase	gnl|CDD|239649	cd03677, MM_CoA_mutase_beta, Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta heterodimers. For P. shermanni MCM, it is known that only the alpha subunit binds coenzyme B12 and substrates. The role of the beta subunit is unclear. MCM catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA. The reaction proceeds via radical intermediates beginning with a substrate-induced homolytic cleavage of the Co-C bond of coenzyme B12 to produce cob(II)alamin and the deoxyadenosyl radical. MCM plays an important role in the conversion of propionyl-CoA to succinyl-CoA during the degradation of propionate for the Krebs cycle. Methylobacterium extorquens MCM participates in the glyoxylate regeneration pathway. In M. extorquens, MCM forms a complex with MeaB; MeaB may protect MCM from irreversible inactivation. In some bacteria, MCM is involved in the reverse metabolic reaction, the rearrangement of succinyl-CoA to methylmalonyl-CoA. Examples include P. shermanni MCM during propionic acid fermentation and Streptomyces MCM in polyketide biosynthesis.	3.65676e-159
NC_014666.1|WP_013426035.1|6053372_6054914_-|LCP-family-protein	gnl|CDD|367673	pfam03816, LytR_cpsA_psr, Cell envelope-related transcriptional attenuator domain.	2.04654e-38
NC_014666.1|WP_013426046.1|6070672_6073417_+|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	8.70591e-78
NC_014666.1|WP_013426051.1|6080178_6082413_+|methylmalonyl-CoA-mutase	gnl|CDD|236508	PRK09426, PRK09426, methylmalonyl-CoA mutase; Reviewed.	0

Protein sequences

>NC_014666.1|WP_013426046.1|6070672_6073417_+|protein-kinase
MAGSTPPPVSGNAPAPLNAADPRKLGKYVITGRLGQGGMGTVFLGHSPDGDAVAIKVIKPELAERPEFRARFRREAESARRVRRFTTAAVLDADPDGPWPYLVTEYVEGPTLSKMVGRRGPLRPADLEQMALSVATALSAIHAAGIVHRDLTPANVLLSPVGPKVIDFGLARDFAGSGEFSRTAKHAIGTPGYMAPEQIMDSPVTSAADVFAWGAITVFAATGRQPFGEGRIEALLFRILYEPANIDGVPDELAPLVDAALRKNPAERPTAEELRISLMSGAALPAARLAASGPTAQEATSTDGKDGARRRRGHLFGRGRHQDGDEAVSGAPVSGAATSLLTPAPATTGAPPSPISAPPTSVGPAAPVSPVPRPVPAPSVAPGAPAGPIARSAGPRPPSLAPRSTTSTPPRSPAPSTPAPHPSAPPPATTPSPVPVSPAPAAPPRPQARPAGERAAAAVTAQVAPPARPAEEARPTGSGRGRRTVVLVAAGLVLLAAAVGLPLALTHGSGGSGGSSSVSPARAAQLSDTLAKAADTARPTDPARAARLSLAAYRISPTQAAASAMVASFAASSKVDLPGSPVAYTGVALTSDGRLGAATDAAGRVRLWNLAAATPALLADIATGDASAPTAPVFLPTGDLLTGGGIGHAWTLADPRAPRAISDVKPQATQPLQLALSGDGRLLVTAGQDRIIELWDLNNPAKPGWLGLKVTPGIITDIALSPDGRTLAVAGVDGTVSLWDLSDRRNPVERGSAVGHLGQVTAVAFLPGSKRIVTGGSDKTVRLWNITDLDAPRQLGEVTQGGSPVVNVAALDANLVVSSDASGSLLGWSVAAANPAESFSLGRGSTGLDLAVGGAGKMLLTAPAGGSSGAASLISTDPARLATVACANPANRIGETEWKSLIADLAYSDPCAGR
>NC_014666.1|WP_013426045.1|6069192_6070278_+|HlyC/CorC-family-transporter
MNDVLKLALVVALLLGNALFVGAEFALISARRTTIEPRAQAGSWSARITLRAMEHVSLMLAGSQLGVTVCTLGLGALAEPTIAHLIEHPFEAVGLPAAAIHPIAFVLALVLVTVLHVVIGETVPKNIALGAPDRAALVLTPPLAGLVLVLRPVIVALNWVANASLRLVRIEPKDEVASVFTRDEVAGLVDESRREGLLEADEHELVSGALAFDERAARDVLLPREGLVTVPTEITPRALEQLAASTGYTRFPVHDFGGRLIGYLHLKDILETRPERRASPVAAKWLRPLVHVPADATLRQALTVMQRSGAHLGQVVDASGESLGLVALEDILEELVGEIRDEAARRPARPVAPAQPAARPV
>NC_014666.1|WP_013426044.1|6067666_6069196_+|HlyC/CorC-family-transporter
MTQALLLVAGVILLAGCGLFVAAEFALVTVDRATVERAARDGDRAAHGTLRALRTLSTQLSGAQLGITLTNLGIGYLAQPAIAELLSGPLGRVGASGQLADDLAVVLALVIATVLTMVFGELVPKNVALARPLATANGAQRFQRGFTAAALPLIRFLNGAANLLLRRFGITPREELASARSAQELFSLVGRSAEHGALARETATLVQRSLLFGDRTAQDVMTPRVRMRSISADEPVAAVIALTRRTGHSRFPVLGEDSDDVVGLIHIKRAVAVPEEDRATTPVRAVMGPTVTVPSTAPLEPLLETLRAGGLQMAIVVDEFGGTDGLVTAEDLIEEIVGDVVDEHDRVSPRAVRHRDGSWALSGLLRPEEAEELTGVPVPTDDAYQTLGGLMAAALGRIPAAGDAVEVAGVGYTVERMDGRRVDRIRLDPPAAGPAPRRHGRRDDPEHAPEDGGHDRDDADRAGQGRQGARPGGGSELADGDVVVDPRRALPPAHPPRGNGRAAGWDGTR
>NC_014666.1|WP_013426043.1|6064773_6067158_-|glycosyltransferase
MAGRGSGGSRRDGSARRAAVPAPRQGEPAGPAQPPRRRPVAQADPPEPDADPPEPDADPPEPDAGLPEPDAGLPADPGTARPARAGWHLVAGSAGLAAAATATAGLVAGAAGAVYLGWRAGHLGGTGFTGGLAFAAELALYLVVVGLAVCAARVNRGFVRRAPAPAGTLDVFVVSRGEPLSDVDRTLRTAQAITYPHRTYLLVDTRIDDAALPGGRGGAWAAAALADRRDITCLTRDDGPPSRTGLLNAALAVTDGDAVLLLDVGDTVCADAAHRVLGYLRDPQVGFVSSAWRPTASGQGPLPDRAEAALARMVAAGRDRDGAATGVGSGTLYRRVALETVGGFGVRAATEEPRTSYELHSAGWASVHHPDVVTARAARPPAVAARLTLARALDRLRILLFDNPLAKTGLTTRQRAHHLGDAALPLLAAAQIGFWLTPALMVLAGGRLSSGTDAVQWLAFGLPYLAATGLFAAAVTTEGGLVGRGLAAALAGWLAAIPLSLLALARIVVLGGRSGAAPDLARRALRSAPGQGPVRATSTAPAAATEVRAVPGKSLPAKSVAGKAVAGKGTAGKSAARKGVAEKAVVGKDTAGKGVAGKAVAGKAAAGKATTSKAALVKAVPTTAVVGKATTSKALVRAKAAPTAGLAKAVPPRVTQGTAPVKAGPAKRAPLAAVGRTGLVKGAWNRTVTAWPSGLTAHPGSALGQLTPDRWTPSLLVVSLPAVALAASVLVAAVRPDRGHLVALAWAGAVLLVAAEAVAAACALQSATVRVGGRLRATIGAAVLIAAALAVAFG
>NC_014666.1|WP_013426042.1|6062452_6063991_-|NAD(P)/FAD-dependent-oxidoreductase
MSENVDVVVIGAGPAGLTASYELHRYGIPSTILEADTQVGGISRTVERDGWRFDIGGHRFFSKVQRVEDFWHEILPQEDFLLRPRKSRIFYQGKYYDYPIKAVNALQNLGPQEAAICIASYLRARISPPKDQSDYESWLVARFGWRLYRTFFKTYTEKVWGVPVSEMPADWAAQRIKSLNLGNAILNAVKPKTNQKEITSLIEEFEYPKYGPGMMWEVCRDKVVAQGSKIRMETKVVEIRHEDGKAFEVVAEDANGGITAYPATDVISSMPISQLIEIMSPAVPPRVLKAAQDLRYRDFLTVALVVPSNAVSWTDNWIYIHDPSVRTMRIQNFASWSPFLVKDGRNVLGLEYTVFENDSEWTAPDDELIEKGKKELDKLGLVAYKDIEAGYVVRQPKAYPIYDDRYGANVDVIRGWLTDYASNVHPVGRNGMFRYNNADHSMYTAMLTAENIVKGTAHDVWSVNVEEEYHEEKDGGSTGSAKPAGSLGTGRDAPVLPRKVLDAARSRVAGSR
>NC_014666.1|WP_013426041.1|6061471_6062404_+|acyl-CoA-thioesterase-II
MDTAATGEVGSFLSLLTLEQPEPDLFRGVSHEGAPLRAFGGQVAAHALVAATSTVEPGRPVHSLHSYFVRGGDTTIPIDYQVERIRDGRSFTTRRITAIQHDEAIFVLSASFHRHEESPVNHQRTAPKAAPPPDGLAFFEGRRRDDEGTETGPSARDTRDDDRREAWGRRGFEVRVVAGFGMAGTGADDRYTGGSGLTAPARLRAWLRVTEKLPDDQHTHACALVYMSDLTLSHSIMGPHGGMAGGMALTSLDHAVWFHRPFRADEWLLFDQGSPTASNGRGLAFGEFFDTDGVLVATVVQEALVRPVRA
>NC_014666.1|WP_013426038.1|6057671_6058670_-|hypothetical-protein
MNASDTAALHDELRSLARSRGLRAANLGARVGPSLRRHAGLGESVGIELRTRLVAWLRDRIAVLPADLRIVVAFALALDPRADQRLLTDRLGWLAVELDRDPRTVRRRCEEAFRLLAETAAAVDPDVPAGRSRSVGLAPAPPALAGPPAGAWYVERVWAVLRLDGPTPELLETRRVVALEDGLRELALSMSLPRPPGAPASPRDLDVDVLFGGRMVRIDRQGDTHYSPVLRLPRALGRHERHDFGCAWRVPAGQPMAPRYALNPTIRCDALDLRVRFPEDADPKVELVDGLPLRAVEDLAIDLPAVALDGVSEAFARFSGLASGLCYGLRWS
>NC_014666.1|WP_013426037.1|6057387_6057543_+|hypothetical-protein
MAREAQGPRSGAAASDLGGCTDGTTGEDEEKAHAGPDHPPDTPPRRRIGPA
>NC_014666.1|WP_013426036.1|6055326_6056856_+|serine/threonine-protein-phosphatase
MGRAATKVRRDRSNDADLPTATSPGLTTKPDARSDKAKKTRGGKGAGPKAPKAELKKSGAGKSDKKSREPSIEAVAGTPAGATNSVVDAIIAAALGEAVAESLTASLAESINESFTEMMAGGLAGALEEALVEAVSTAVARDLPDAFASVAVASLTGQPAVDLDAPGSGAGSTAPAVTPPGEPGGRPAAGSASSTRTAPGPARASDGHAVEVAAARSLWEALPPRRLPVLPSLDLAARRLAASDPDRVGGDWYDAIALDADAVVLGVGDVAGHGPGMAAQMAELCHAARAYALLDLPPAQITGRLTEVLRAGGHRSLASTCTARLDIPTGRLTWCNAGHPPPVLITAQGDVSFLGDVHGPLLGAAPGAGPGTSLAGGPGVEGGTEYAQSTVTLPSGATVLFYAAGLVDQPDAPIAHRLDALATAASKAFGTAASTSATGSSATDTSATSTSASGGVQPGVDVRPLAAACDALLTELSTARAASSGQSDAARQPRPRRDSDSVLLAARLR
>NC_014666.1|WP_013426035.1|6053372_6054914_-|LCP-family-protein
MAQRDGRTGPRRLLPPPDVEPRRPGTRRSPFRRPVLVVLAVLSFSVLVVSTVGWAGYRRFDSALTRENGWNLAGASDPSGTMNVLLLGSDSRAGTGGEYGQVDGDRSDTTIIAHFGADGAVTLLSFPRDTLVPVVPRVAGVPADGRSKLTDVLNLAGVPGLITTLQALTGLRIDHTISIDLAGFKAMTDAVGGVTVCVRPLPDGGTGNLNDAWSQWHGHLGENRLNGEQALAFVRTRHALGDERLRILRQQQFLARLLAKATGLGVLTNPVRLAALLGAVGGSLTVDKGLGEQQLVALANRLATLGPGKLTFTTIPTHVPTRAEGAIDDRGTVPSHQQVLFLDQDAFERLVGPLRSTAGRRSGAPAHPATTGGATGTPAPAVGPTLAPGAVTIAVVRNAAGRNGLAAQTAAYLRERGFTGPMTVADAHGTLATTEIHYGSAGPDVGAGVAAARTLAALIPGARLVPDPAARHGLVVILGGAFTRLATGGPSTPPPASTSPPAVPAPADTSCTP
>NC_014666.1|WP_013426048.1|6076182_6077652_+|NAD(P)/FAD-dependent-oxidoreductase
MVQRGAERGRPDGLDAVVVGAGPNGLVAAVTLAEAGWRVLLVEAAGRPGGGLRTEELTLPGFRHDVCATVLPLALASPALRGYGEADGVRWAHPAVPLAHPLDAGPAALLRRDLATTAAGLGGTGWRRLFGPLVAAGPRLADGVLSLLDLPPAAPLALAGYGAAGAWPATWLARAALRGDRARALFGGLAAHSMLDLGRPITAGYGLLLGVLAHQVGWPVAVGGSATVADALVARLRALGGELVTDHPVTRLADLPPARAVLLDLTPKQVLRIAGDALPAGYRAALSRYRYGPGVFKVDWALDGPVPWRDPAVGAAGTVHLGGTLAEVTAAERAVARGRHPDRPFVLFVQATVADPTRAPAGKHTGWAYCHVPLGSTVDLTGAIEDQVERFAPGFRDRVLARHVMGPAALEAHNANEVGGDIGGGSADLRQLLARPVLSRRPWATPLPGVYLCSAATPPGAGAHGMSGHHAATLALRQADQPGPGRPGG
>NC_014666.1|WP_013426049.1|6077659_6078121_+|hypothetical-protein
MLIRVEGTDLPGRRCAGPAGSADYENIHVAVQRRERPAELLDPVAADAATAVWTLECTATVTPGAVDLKGRYVQGRPGERFIYLNWVAADPVGGGFTMFRRAKLWLNAVPDDVLTAAVQSGVLVGRLGLTDAKGHPTCASVRPPQITWSAATA
>NC_014666.1|WP_013426050.1|6078223_6080179_+|methylmalonyl-CoA-mutase
MTVPSADLELASLFPPATREAWQKLVLGVLRKSGTAGEQALPADAEALLSTASYDGFAIHPLYTAEDTPPVEAGLPGHAPFVRGRRAEGANVEGWDVRALHTHPDAKVTAEAILDDLEGGATSIWLRLAAPSADSGEVLSAEALPDVLREVYLDLAPVVLDTGGDAVTTTAAADVLLALAGVRGVAPSAVRATLGADPLGFAARTGLGGDKLTAHLDEASRLAQRVAADYAGVRTFVVDATPYHDAGGSDAQELGASLATGVAYLRALTGSSRAAGEEAGALDVAGALAQLEFRYAATADQFATIAKLRAARLLWARVAEVCGAAGADRAQHQHAVTSSAMMTRRDPYVNLLRTTIAAFAASVGGADAVTVLPFDDRLGLPDGTSRRLARNIQALLHDESSLARVIDPAGGSWFVESLTAELAEAAWAFFTEIERAGGMAAALASGLVAERIDATWARRREDLALRRAPLTGISEFPNVAETLPERSPAPARAAAPGGLPVRHYDDDYEALRARSDAHLAATGARPVAFLATIGPLATFTPRATFAANLFQAGGLETPAAGPGDDPAAIAAAFTASGAKIACLCSSDKIYAASAAPVAAALKAAGATHVWLAGKPGDRADSDAAAGIDGYVATGGDAVDVLRTALTKAEVA
>NC_014666.1|WP_013426051.1|6080178_6082413_+|methylmalonyl-CoA-mutase
MPSNLIPDFSEVPLGGGAAAPVGVEDWRAAVKASVGKDVDELSWDTPEGVEVKPLYTAADTAGLDFLGTYPGIAPFLRGPYAPMYVTQPWTIRQYAGFSTAADSNAFYRRNLAAGQKGLSVAFDLPTHRGYDSDHPRVTGDVGMAGVAIDSIYDMRQLFDGIPLDRMSVSMTMNGAVLPILALYIVAAEEQGVAPEQLAGTIQNDILKEFMVRNTYIYPPKPSMQVISDIFSFTSQRMPKFNSISISGYHMQEAGASADLELAYTLADGVEYIRAGLDAGLGIDAFAPRLSFFWAIGMNFFMEVAKMRAARLLWARLVKQFEPQSEKSLSLRTHSQTSGWSLTAQDVFNNVARTCVEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQLFLQQESGTTRVIDPWGGSYYLERLTHDLAKKAWGHIAEVEERGGMASAIDAGIPKLRIEEVAARTQARIDSGRQPLIGVNKYRLAGKEDIDVLKVDNTAVRAEQLAKLRQLREDRDPHAVDAALAALTRAADEAQAGTRAAGLDGNLLKLAVDAARAKATVGEISDALEKVYGRHSAQIRTISGVYRDEAGPSPEIGEARRLATAFAEAEGRRPRILIAKMGQDGHDRGQKVVASGFADLGFDVDVGALFQTPAEVARQAVEADVQVVGVSSLAAGHLTLVPELRAELAKLDRADILVTCGGVIPPQDYDALRAAGAVAIFTPGTSVAQSAIEVLGILADQLGHDLGPAA
>NC_014666.1|WP_041259633.1|6082514_6083540_+|methylmalonyl-Co-A-mutase-associated-GTPase-MeaB
MPARRPVDVDAYAEGVLANNRTMVARAITLVESSRADHRAAAQALLVKLLPHTGKARRVGITGVPGVGKSTFIDALGTMLTGQGHRVAVLAVDPSSTRTGGSILGDKTRMADLAIDPNAFIRPSPTAGTLGGVAKATREAIVIMEAAGYDVVLVETVGVGQSETTVADMVDTFLFLTLARTGDQLQGIKKGVLEIADVITVNKADGPHLIDAQRAARELAGALRMLRAPDDGWRAPVLTCSAIEKTGLAGVWEQVVAHQDMLDAAGLLAARRRRQQVDWTWAMVHDRLLTDLHTHASVRALAPDLERQVRDGTLTPSLAADALLAAYGTDGTDRSTQQAAL
>NC_014666.1|WP_013426053.1|6083544_6084906_-|hypothetical-protein
MFGFELQTNGNNFVDGVRPREVAWKSDDGLVTLEGDETYEDPRWAELEFVTAPCKDLNTARQAAATAQILATALAREARGNAGVVRFRDTQTFEKGTWVKTGSMVVKNLDFAAKPQVTVGVALPAMRRFLTTALANTGALVTVETLTSLRQMAALRFKEHSISPEVAGSPEMDGFLAACHYFLLKSFVYDIPYYAVDEEGRPGLPRDHDLWRVFEWDSPYLASLKYKGSAPLKTGRGDICRVAVNRDAPKSLYEILHRTDFYAMFRLIPERLRAGITKDVLRDVLWPDLSWSRNFILMVVPYRADPLEDRLQPVPVSRKGTGWKDGVRDTSTKVDHWHLTDGGPLYQDWCASVLDGRQAADKGAALPKDLASPPPGIRGRERAHLDEFPTSAEDKSTYYGMGAFPADKGGLAVYEHRAFASDTCIKHTQTGELVPSANWVTLVEAFHKTYQPA
>NC_014666.1|WP_013426054.1|6085389_6086163_-|class-I-SAM-dependent-methyltransferase
MGEPFGGWAPAEYGDRIADVYDHWYEGLDEALPAAVELLAKTAKGGQALELGIGTGRVALPLAAAGVKVAGVDASERMVARLWAKPGGADIPVTFGDFGDPAVLAEAAGTSGDVSLVYVVFNTLFALPTQAEQVRVFAAASEVLAPGAAFVVQAFVPDQSLFARGTRFSTDRIEGDESRLTAAVHDRNAQTVRANHVVLSPRGIETYPVNLRYAFPAELDLMAALAGLTLEARFGTWSGEPFTNTSGSHISLWRKLA
>NC_014666.1|WP_013426055.1|6086514_6087930_-|HNH-endonuclease
MVDASIDAALARLAVSDPADTLALVSEIARTTARLQGLMIHAQVHLARLRPPSAGDWADPSAEPYSEFAADELAAELGQSPRAQSERLATAWDTAHHLPGSLAALTAGTLDYPRLAALQQLTMGLSDAQRSLVEDTMLAGNRLKSTPQWRRKIRRLVAKIAPEALTRRRAEAHARRGVSIEPLDDGMALLQATLAAEDARAVFDRIDSLARASRTQTGPTGVGGEAEENRPLDARRADVLAALLLGNRREYVTVELQVIAPVGTLAGLDDNPAELVGYGPIPANVGRALASDAQWRRVLTDPESGTVLDLGHRRVPTPALARLVRHRQGRCVFPGCGMPATQADLDHTVAHAAGGRTALDNLGLLCRHHHRAKHVAGGWRLDQPSPGSFRWTSPSGRTYVADTTTNDEEAVLPWEQHRPKDIHAEDPPASPASPGRAPSVGSRTARPRRPEPFCPSRQPTAGPRATEPCPF
>NC_014666.1|WP_013426056.1|6089031_6090123_-|hypothetical-protein
MPARPNRTWPKYVNIGMIGRSWAGRALAAGIVTTLALVTACHEGEATNPLVERYYQGWPAGAGLSGPAGASPAGAGPVALLRPNHRLELALSGSSSCPSLPVALTVVDRHAVEVRAAPLAPTSRSGPTRSEALVVCTDDNVPTTSVLRLPSAVDTTRPVLVTVHVDPGGAAEIVTAYPAAGLISPGPARPGTGPTGLAQTGGPTGLATRPDNLQVGGQVLPADAVSSRAAIRAAFDRALTGTDPAGTTSAPGGAGFGPTDRAGWALAAVEDGPAMRRPLAELIRRFPAAARSSRIVVGEIDFVDVNHATVRYTLSFTGAGSGAPRTGTAVRVGAGTAADPDWKVGRDTYCAVLSLANVACPPA
>NC_014666.1|WP_013426057.1|6090199_6090796_+|sulfite-oxidase-like-oxidoreductase
MGIVSPGFHGRRRGNTMLPPGQYEEEDFPVLSAGPTPRVPTDRWQFTITSETGERYSWSWAEFQALPQETPTVDIHCVTRWSKFATTWKGVSLDTLFEDVETAADYAMIHSYGGYTTNLPLEDLLDGQAWVAHRYDGEDLDPEHGGPARLLVPHLYFWKSAKWVRGIQLMPEDSPGFWEAAGYHDRGDPWREERYQGD

Crispr_ID: NC_014666_14

• CRISPR_ID: NC_014666_14
• CRISPR_location: 6160150-6160399
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 5 spacers

Consensus repeat of NC_014666_14

Consensus_repeat	Method
CTGCNGCCAGCCNCNCTGC	CRT

spacers of NC_014666_14

>14.1|6160169|23|NC_014666|CRT
TGCTGACCCTGCTGCGGCGGGTA
>14.2|6160211|23|NC_014666|CRT
TGCTGGCCCTGCTGCGGCGGGTA
>14.3|6160253|23|NC_014666|CRT
GGGTCGCCGCCCTGCGGCTGCCC
>14.4|6160295|20|NC_014666|CRT
ACCTGGCCCGGCTGCTGGCC
>14.5|6160334|47|NC_014666|CRT
GGCGGCTGCTGGTAGGCACCCGGCTGCGGGGCTCCCGGCTGCTGGCC

CRISPR arrays and Neighbor proteins around NC_014666_14

CRISPR arrays

The CRISPR arrays of NC_014666_14

>merge|NC_014666|14|6160150-6160399|CRT
CTGCGGCCAGCCGCCCTGCTGCTGACCCTGCTGCGGCGGGTACTGCTGCCAGCCGCCCTGCTGCTGGCCCTGCTGCGGCGGGTACTGCTGCCAGCCGCTCTGCGGGTCGCCGCCCTGCGGCTGCCCCTGCTGCCAGCCACCGGGGACCTGGCCCGGCTGCTGGCCCTGCTGCCACCCGCCCTGCGGCGGCTGCTGGTAGGCACCCGGCTGCGGGGCTCCCGGCTGCTGGCCCTGCGGCCAGCCCGGCTGC

>NC_014666|14|1|6160150-6160399|CRT
CTGCGGCCAGCCGCCCTGC	TGCTGACCCTGCTGCGGCGGGTA
CTGCTGCCAGCCGCCCTGC	TGCTGGCCCTGCTGCGGCGGGTA
CTGCTGCCAGCCGCTCTGC	GGGTCGCCGCCCTGCGGCTGCCC
CTGCTGCCAGCCACCGGGG	ACCTGGCCCGGCTGCTGGCC
CTGCTGCCACCCGCCCTGC	GGCGGCTGCTGGTAGGCACCCGGCTGCGGGGCTCCCGGCTGCTGGCC
CTGCGGCCAGCCCGGCTGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_014666.1|WP_157735514.1|6170686_6171493_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
NC_014666.1|WP_013426119.1|6167249_6168380_-|hypothetical-protein	unknown	unknown	gnl|CDD|367576
NC_014666.1|WP_013426106.1|6153011_6153551_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|379326
NC_014666.1|WP_157735031.1|6156655_6157663_-|EamA-family-transporter	unknown	unknown	gnl|CDD|223769
NC_014666.1|WP_013426113.1|6159169_6159499_-|transglycosylase-SLT-domain-containing-protein	unknown	unknown	gnl|CDD|381607
NC_014666.1|WP_013426124.1|6172053_6172485_+|glyoxalase	unknown	unknown	gnl|CDD|319924
NC_014666.1|WP_013426110.1|6156093_6156540_-|NUDIX-domain-containing-protein	unknown	unknown	gnl|CDD|240045
NC_014666.1|WP_013426112.1|6158071_6159028_+|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|334634
NC_014666.1|WP_013426115.1|6161156_6162164_-|EamA-family-transporter	unknown	unknown	gnl|CDD|183142
NC_014666.1|WP_013426104.1|6150253_6151705_+|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl|CDD|223715
NC_014666.1|WP_013426116.1|6162235_6163219_+|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|223656
NC_014666.1|WP_013426118.1|6164870_6167180_+|DEAD/DEAH-box-helicase	unknown	unknown	gnl|CDD|350677
NC_014666.1|WP_041259638.1|6153547_6153829_-|DUF1778-domain-containing-protein	unknown	unknown	gnl|CDD|226860
NC_014666.1|WP_013426121.1|6169792_6170599_-|enoyl-CoA-hydratase	unknown	unknown	gnl|CDD|235852
NC_014666.1|WP_041261376.1|6163156_6164464_-|MATE-family-efflux-transporter	unknown	unknown	gnl|CDD|240541
NC_014666.1|WP_013426120.1|6168405_6169620_-|SPFH-domain-containing-protein	unknown	unknown	gnl|CDD|372597
NC_014666.1|WP_013426108.1|6154123_6154990_+|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|187597
NC_014666.1|WP_157735032.1|6171594_6172011_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|197666
NC_014666.1|WP_013426105.1|6151781_6152738_-|hypothetical-protein	unknown	unknown	gnl|CDD|375092
NC_014666.1|WP_013426109.1|6155012_6155984_-|NUDIX-hydrolase	unknown	unknown	gnl|CDD|226316

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_014666.1|WP_157735514.1|6170686_6171493_+|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.99464e-09
NC_014666.1|WP_013426119.1|6167249_6168380_-|hypothetical-protein	gnl|CDD|367576	pfam03604, DNA_RNApol_7kD, DNA directed RNA polymerase, 7 kDa subunit.	0.00343178
NC_014666.1|WP_013426106.1|6153011_6153551_-|GNAT-family-N-acetyltransferase	gnl|CDD|379326	pfam13673, Acetyltransf_10, Acetyltransferase (GNAT) domain. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	4.28888e-07
NC_014666.1|WP_157735031.1|6156655_6157663_-|EamA-family-transporter	gnl|CDD|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	2.63753e-16
NC_014666.1|WP_013426113.1|6159169_6159499_-|transglycosylase-SLT-domain-containing-protein	gnl|CDD|381607	cd13925, RPF, core lysozyme-like domain of resuscitation-promoting factor proteins. Resuscitation-promoting factor (RPF) proteins, found in various (G+C)-rich Gram-positive bacteria, act to reactivate cultures from stationary phase. This protein shares elements of the structural core of lysozyme and related proteins. Furthermore, it shares a conserved active site glutamate which is required for activity, and has a polysaccharide binding cleft that corresponds to the peptidoglycan binding cleft of lysozyme. Muralytic activity of Rpf in Micrococcus luteus correlates with resuscitation, supporting a mechanism dependent on cleavage of peptidoglycan by RPF.	2.73415e-14
NC_014666.1|WP_013426124.1|6172053_6172485_+|glyoxalase	gnl|CDD|319924	cd07263, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	2.06487e-32
NC_014666.1|WP_013426110.1|6156093_6156540_-|NUDIX-domain-containing-protein	gnl|CDD|240045	cd04689, Nudix_Hydrolase_30, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U=I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	2.03179e-25
NC_014666.1|WP_013426112.1|6158071_6159028_+|alpha/beta-fold-hydrolase	gnl|CDD|334634	pfam01674, Lipase_2, Lipase (class 2). This family consists of hypothetical C. elegans proteins and lipases. Lipases or triacylglycerol acylhydrolases hydrolyze ester bonds in triacylglycerol giving diacylglycerol, monoacylglycerol, glycerol and free fatty acids. Lipase EstA is a extracellular lipase from B. subtilis 168.	2.85504e-22
NC_014666.1|WP_013426115.1|6161156_6162164_-|EamA-family-transporter	gnl|CDD|183142	PRK11453, PRK11453, O-acetylserine/cysteine exporter.	3.18497e-61
NC_014666.1|WP_013426104.1|6150253_6151705_+|HAMP-domain-containing-histidine-kinase	gnl|CDD|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	3.40686e-45
NC_014666.1|WP_013426116.1|6162235_6163219_+|LysR-family-transcriptional-regulator	gnl|CDD|223656	COG0583, LysR, Transcriptional regulator [Transcription].	5.5705e-28
NC_014666.1|WP_013426118.1|6164870_6167180_+|DEAD/DEAH-box-helicase	gnl|CDD|350677	cd17919, DEXHc_Snf, DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins. Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	4.09041e-48
NC_014666.1|WP_041259638.1|6153547_6153829_-|DUF1778-domain-containing-protein	gnl|CDD|226860	COG4453, COG4453, Uncharacterized protein conserved in bacteria [Function unknown].	7.16623e-07
NC_014666.1|WP_013426121.1|6169792_6170599_-|enoyl-CoA-hydratase	gnl|CDD|235852	PRK06688, PRK06688, enoyl-CoA hydratase; Provisional.	3.47242e-60
NC_014666.1|WP_041261376.1|6163156_6164464_-|MATE-family-efflux-transporter	gnl|CDD|240541	cd13136, MATE_DinF_like, DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	1.08185e-81
NC_014666.1|WP_013426120.1|6168405_6169620_-|SPFH-domain-containing-protein	gnl|CDD|372597	pfam13421, Band_7_1, SPFH domain-Band 7 family.	2.28075e-130
NC_014666.1|WP_013426108.1|6154123_6154990_+|SDR-family-NAD(P)-dependent-oxidoreductase	gnl|CDD|187597	cd05338, DHRS1_HSDL2-like_SDR_c, human dehydrogenase/reductase (SDR family) member 1 (DHRS1) and human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs. This subgroup includes human DHRS1 and human HSDL2 and related proteins. These are members of the classical SDR family, with a canonical Gly-rich NAD-binding motif and the typical YXXXK active site motif. However, the rest of the catalytic tetrad is not strongly conserved. DHRS1 mRNA has been detected in many tissues, liver, heart, skeletal muscle, kidney and pancreas; a longer transcript is predominantly expressed in the liver , a shorter one in the heart. HSDL2 may play a part in fatty acid metabolism, as it is found in peroxisomes. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	3.16074e-54
NC_014666.1|WP_157735032.1|6171594_6172011_+|helix-turn-helix-domain-containing-protein	gnl|CDD|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	5.49811e-28
NC_014666.1|WP_013426105.1|6151781_6152738_-|hypothetical-protein	gnl|CDD|375092	pfam17270, DUF5336, Family of unknown function (DUF5336). This Actinobacterial family of proteins has no known function. Most of the family members are predicted to have have 4 trans-membrane regions.	0.00025164
NC_014666.1|WP_013426109.1|6155012_6155984_-|NUDIX-hydrolase	gnl|CDD|226316	COG3793, TerB, Tellurite resistance protein [Inorganic ion transport and metabolism].	7.25028e-17

Protein sequences

>NC_014666.1|WP_013426113.1|6159169_6159499_-|transglycosylase-SLT-domain-containing-protein
MIATPALAAAVVGTGLVATQPASAAARPSAAHFLSAVVPCESGGNPRAVNSIGAGGLFQFLPSTWHGLGGRGLPQNASVSEQWAKAYKLYAQQGTSPWYASKGCWGHKI
>NC_014666.1|WP_013426112.1|6158071_6159028_+|alpha/beta-fold-hydrolase
MLVHRPRRRLPRRAALIALPAALVTALFAGGAATAAAASAAAPLPVIYNFPAAVAISLAHPNADPPGSNDFSCRPSAAHPRPVVLVHGTLADKTNEWQALAPLLKNDGYCVFAPNIGGASPDAYIQATAPIEQSSAQLATFVDQVLAATGASKVDLVGHSQGGMLPRYYINNLGGDAKVNSLIGLAPSNHGTTLDGLAQIAQALGLSSTVASACASCAEQIIGSPFLTALNAGGGTRPSVHYTVIETRYDEIVTPYTSAFLSGSNVKNITLQDSCILDGSDHISIAYDRVALRFVENALDPQHPKPPICVPVLPVVGG
>NC_014666.1|WP_157735031.1|6156655_6157663_-|EamA-family-transporter
MRSLSSATTRWWVSGRVLGGAGVLAFSMSLPATRVAVEDLNPWFVAFARAVGAGLLASGYLRLTGSPRPTRDQWRRLAAVALGVVFGFPLLTSLALTSQTAAHAAVVIAVLPACTAVFAVLRGRERPPPLFWAAALAGLVAVLAFLVASGAVSGGVGPADLALLGAVGLCGLGYAEGGRLARELGGARTICWALVGSLPLTVPATVVVTILDPPGAAPVSWLGFAYVTVVSMFLGFFAWYAGLARGGVARTGQLQLAQPVLTLAWSALLLREHVSPAALAVSALVLACVALTQYTRSGDARSGDARRNVNGAIGAQRQWERQCDPAAGLSNARKQ
>NC_014666.1|WP_013426110.1|6156093_6156540_-|NUDIX-domain-containing-protein
MAPSADRTEISARLLILTEDRVLLAGHRGRTWYFLPGGRLSPGETIEHALRRGTGQETGFDIRALDFVGCVEHDYSVGTDKVHELMTVFAAPLPWAAQIISHDPELHLFSVDLDDLARRDLRPAALKNMIFDWVRDARPAWRTSLPAG
>NC_014666.1|WP_013426109.1|6155012_6155984_-|NUDIX-hydrolase
MAVPPAIRLDVRLVALVDDKVLLTRPAAELWHALPGGPVGAGEGAERALARHLDGLLVPAAGALAFAGAVEHTGDAGEAAAGPSAPDSPGADGAEPSWAHGTPGSEHVLTLLFAAEWPAGDEAPRAWRGQQVSLVGVDDLVVTRLAPLPVAWATRHWLANARPGWRRLAPAAAEAAWHGGRPPVAAVRAQLAARRDQLRGRRFRDAAVAMCALVAAADGRIDPAEREGLRAFLATDPVMAYFPTDELERVFEQRLAALAADFEAGKHDALGEIAKVRGRPAEATAVLRLGEVMGRIDGAFPPVEQEVLGEAAAVLGLDSAHSA
>NC_014666.1|WP_013426108.1|6154123_6154990_+|SDR-family-NAD(P)-dependent-oxidoreductase
MGDAEGRVALVTGASRGIGAAIAIRLAAEGAAVALTAQAVHEGDPRDPGSLAGVLARIADAGGTAIALAADLSRPDGGREGLVAAVERRLGPLDILVNNAGMGGYMPFLDIADQRIDTVFEVNLRTPWELCRQALPGMRARRRGWIINIGSAAAEAPAGPPYRSTLPDLQGSLYGSSKAALHRLTMSLAAEAYADGIAVNVLAPDPAVRNRDDWPSPDTSPEPVETMAEAALALATCSPDELTGRVAYSLSLLVELDRPVHGLDGVTEFAGWQPHEIPRSRLRQPPAG
>NC_014666.1|WP_041259638.1|6153547_6153829_-|DUF1778-domain-containing-protein
MGATDEGEQVTVRLTGEAAELVRSASDSLGVTLEDFAAEAMRRHAADTLADRRLFGATDVAWKELAELLGGPAPDEAARLRELLEDGPDEEAR
>NC_014666.1|WP_013426106.1|6153011_6153551_-|GNAT-family-N-acetyltransferase
MSPRASGPPTRLTDQHDTRGFRGGDEVLDSWLRHHALEQQEEGVTTFVVTAGAGRVVGYYCLTRGAVEATRAPVVSRWRSRRAPAAVLGPLPALVIGRLAVDETAQGQGVGARLLRDAVMRAATVYRTAGLPLLLAHAVSDQARSFYRHFGFAATRLDPYVLALAVRHASTGSGPDLGG
>NC_014666.1|WP_013426105.1|6151781_6152738_-|hypothetical-protein
MANMAGRGPATQDGPGTTATKAGRGKGQSFASHDVPIIGLGILGLIFSFLPWFGTRYRGYTYDNYGYGTLHTWTGSLNAWHSGALAWIPIVLMLVAAGLAAAHLLGRGKVPGSGASHSTAIAALCAVAALLIVIRWISLPHVHANYGYAAVASGARYGLILGLITSLVMTLLALRRLKASGERTHGQGHVERDASMSGYSGRGAERARVIDRDRQYAGRDDQPQEVGHPGGTTAERSRPDSRGGYGSEGRGGYETEGRGGQGSESRGAYRGPDNGGAYGQEEGRGGYGQESRGGYGTGPTTDPGAGGRDPGRDQHWDR
>NC_014666.1|WP_013426104.1|6150253_6151705_+|HAMP-domain-containing-histidine-kinase
MSKRVIAIQLLLIALLLVGVCIPLGMDAAEHDRDLLTARAAAAADAYASEVKWRRLSTGRVKLPSEEDDDMALYSPDGVLTSSSGRPIPLTAAQLHSACTARVVLSPSATDGGRVVVLTPVTSDKGLLAVLVLARSDHATQVAIRNRWIRLFGGAGLASLVALALSVLLAQWVSRPLRRLERAAATLGDGELSARARAVGGPGEVRQLAASFDAMADRIEELVGGERAFLADVSHQIRTPLTAMRLRLELLTEDLLDNPVAAMEVGGTLTEVHRLSRMVDGLLAMARAHARDTARLPVAVDEVVAQRAVTWWPVAQAAGVELWTDVRDTTGALLTPGHLEQVLDNLLANALEASPPGGRVVVATAPAPALAGDVPMLRLTVTDDGPGMPAAARARAFERFRSETAKSRPVRADRRGNGLGLAVVHALVTADGGQVRLAEAASGGLLVVLDLPAAHTVAAVAAEAAPAPGADRGERHARASATG
>NC_014666.1|WP_013426115.1|6161156_6162164_-|EamA-family-transporter
MPPRHRLLAVVVAIAWGLNFLAIDASLRHFPPFLLAAVRFSVIAIPTLFLVPRPAVPTRLLLGYGLGFGTLQFLFLYWGMHAGMQPGLASLVLQSSAPFTVLLGAVGFRERVTPRRLAGLLVAVLGLGVVGWTRAHDAAAFGPFLLVLAGGFGWAIGNVCNARAHAPNPFHLTLWMSVVPPVPMLALSLLVEGPHRVAGAFTTTGHLWSALAGLAYTVVIGTLLGSGIWSWLMARHPAGLVAPFSMLVPVVGLSAAAVLVGERLSAAEIAGAVLVVGGVLYGATSRSGAVPTSAARRSAGRAGGPAAPPGEPAEARGPSRAGRAPSRSVSVPPAA
>NC_014666.1|WP_013426116.1|6162235_6163219_+|LysR-family-transcriptional-regulator
MDVRHLELLRDLAERGSITAVAVATHRTPSAVSQQLRTAQREFGVGLVEPHGRGVRLTDAGRLLAGAGRDVARVLAEVQARFDEFRGEPAGLVRVAALPSAATLLLPGVLAELETTAIRLECDDVDLPEQEYGRLATDYDIVIGHSLHAGPPPGAEGLVTVALAREPLDIAMRAGHPLADGPTVTAAQLIEVEWYGVPLGYPFDVIRLAVEAATGRPVMVVQRLRDNRLVEALVARGDRVAVLPRFTTPTGHGLELRELAGLDTGRHLLALLRPDRAERLAVRHALASFRRHAADIAARHGRGPGHPSDAGGPGGAPGQPPGAEGAR
>NC_014666.1|WP_041261376.1|6163156_6164464_-|MATE-family-efflux-transporter
MRLALPALGALVAEPLFLLADTAMVGHLGTAPLAGLSLASSVLGTAVGLMVFLAYATTPTVARLRGAGDERAAVAAGLDGLWLAAGLGAGLALLGWWVTPSLVGAFGADRAVDAQASRYLSISMAGLPAMLLVFAAAGLLRGLHDTRTPLVVAALGFGANAALNAAFIYGAGWGIAGSATGTVLAQWGMVVAYLGVVAGHARRVGASGRPRGVGVLRGARAGFWLLLRTASLRAGLLLVTYTATALGSDELAAFQVAMTLFATAAFALDALAIAAQVLVGDRLGGGDLAGVRAVLRRCVAWGVGSGAAVGVVLASLAWVLGPAFTSSAAVARLVVPAVLVLAAGQPLAGLVFVLDGVLIGAGDNRYLAWTGLANLAAFALLAGAVLRWAPRGEWGLVCLMGAYAVGSLAARAGTLSPRAFGSRWLAGGAAGASRV
>NC_014666.1|WP_013426118.1|6164870_6167180_+|DEAD/DEAH-box-helicase
MAFRLPDEKQAPVGSVEARRLLDDATALRDLADDALAREEDARTEVARRFQVVRATLARRDLATMDVERLKDTADDRLPFPALRRAGYRTVADLVDERPEVLDAHPGIGAVSANRAIAAARALDQAAQERLGLRVAMDPSDERATDLLRWLRRVVQLADALDDVRGPAGVLANDLPALVTAAAPTRSRTRMLFAGERRRVAARQVLDQVRRLLDDAETAGIADRLTAAGRLARTAPGDTGVWGDFERAAVRYYGLLGEIVGIRDTTDAAAGQLPEDIAARVREQRLDGEFRTVSLRGYQAFGAKFALAQRRVILGDEMGLGKTVQAIAALAHLRALDQTHFLVVCPTSVLVNWLREIARHSTLTAHRLHGPDRADAARRWLAEGGVAVTTFDTLSALELPTALRARVDVPTQRDRVRRRRTVAAGPPGPRIAMLVADEAHYVKNPATKRAEALRALVNRADLVDRVLFLTGTPMENRVDEFRQLVGYLQPSLLPVNPAARRPRDTPELSPARFRTLVAPVYLRRNTHEVLSELPDRVSTDEWLERGSRAEQAAYRKAVLDRKFMAMRRVAFTGDPEHSAKLDRLVDIAREAGQNGQRVVVFSFFLEVLDIVGRRLRADPECGAVFGPITGAVAAEERQQLVDDFGRRPAPAVLLSQIVAGGTGLNMQAASVVILCEPQVKPTLEEQAIARLHRMGQIRTVQVHRLLTTDSVDQRLVEILAAKRVEFDAYARRSDLADAGPEALDVSDEVLTKQVLEEEYARIAKTGARA
>NC_014666.1|WP_013426119.1|6167249_6168380_-|hypothetical-protein
MTDQGFQQASVASATYPCGGCGARLEFAPGSTSMRCPYCGFTQEIAAGDREIHEIAIENLATLPRKPVGSIGAYVYVCQRCAARSESNETATLCQFCGSPLVIDPAATGQIVPEGVLPFGLDRSAVRDAVRKWTSSRWFAPKALKKVTETESMKSTYVPHWTFDSRTFSGYDGERGDHYWVTESYTDSEGKQQTRQVQKTRWHRASGNVDRVFDDVLVPGSSVLPPKKVDDLAPWPLDAAQPFQQEFLAGHFALRYDLEPESGFEEAKNRMAPVIAEDVRRDIGGDEQRIHHVNTQHNNVTFKLMLLPLWIATFLYAGRSWQILVNGMTGEIQGERPYSKLKIFFAVVAALIVIGVIGFLVAGHGGHHHTGTTTRH
>NC_014666.1|WP_013426120.1|6168405_6169620_-|SPFH-domain-containing-protein
MDIMGRIRGEFVDIIEWTDDSRDTIVWRFPRYENEIKMGAKLTVRESQAAVFVNEGQIADAYPPGMYTLETQNMPILSTLKGWKYGFNSPFKAEVYFVTTRQFTDLKWGTQNPVIVRDPEFGMVRLRAFGAFSMRVVDPGLLLKELAGTDPQFRTEEVSEFLRQLIVGRLGGALANAHVPMLDLATRQDQIGGTLAKALTEELAPYGIAIPKFVIENISLPPEVEEAIDKRSQMGILGNLDQYTQFQTANAIEAAAQNQGGAGEGLGIGLGMALGQRAAGGVGQPGYQQPGYQQPGFQQPGYQQPGPGYQQPGQQQPGYQQPGQQQAPSAPPPLPTPEQWFLGVNGQQLGPFDRGQLAQQISGGQLRPDTLVWKNGMAAWTAAAQVAEVAPLFGSVPPPLPPQA
>NC_014666.1|WP_013426121.1|6169792_6170599_-|enoyl-CoA-hydratase
MDGRHCSGPGTLGAVTCTVTDEVATLTMTTPSLTEIAKIALRDAVERVARDDAVRAVLLTGTGGVFSAGRDLREHTAAVRAEGRDAFDGAADHYSPVVTALATMPKPVVAAVNGTCAGAGLGLALSCDVRLAAAGARFTAAFTGSGLTPDSALAASLVKVVGGARASELVLLTEPFTADDALAWGLVARVLPADELLPAAAALARRLAAGPPRAYAIAKSAMRQAWAASLEQVLVAEGRDPAALAAIDDHRAAVEAFPTKQPPRFTGR
>NC_014666.1|WP_157735514.1|6170686_6171493_+|GNAT-family-N-acetyltransferase
MVSLGFRTDLMLRRLAGAVITERPSYLAVRTPGNPGFWWGNFVLVDRPFAAGDAGRWADVFAREFPGAAHLALGVDGIDGDAGDAVELARLGLTVEVDTVLTATRLTPPARPPAGATIRPLAGDADWAEAFELRLAAHGEQDASAEYRQYVARKLAEERALCDAGHGAWFGVFVDGRLGASAGLFADGDGDRLGRYQSVETHPDLRRRGLASALVHRLGDWGRGELGVRTLVIVADPDYHAIRLYRALGFTDTEKQVQLYREPPAAEA
>NC_014666.1|WP_157735032.1|6171594_6172011_+|helix-turn-helix-domain-containing-protein
MVALARHLLRAKDLADGRYFEALTVADLARAAGLSPAHFSREFRAAFGQPPHQYLLTRRLERAAALLRNTDRDVTEICFAVGLTSVGSFLTSFRRIYGVTPSSYRASFPPAQRHIRVPDCVARVYGRPRNRTFREAGG
>NC_014666.1|WP_013426124.1|6172053_6172485_+|glyoxalase
MIRIANAQFWVHDQDEALAFYTRKLGWEVRSDVTMAEWSFRWLVVGPVGQDDVGLVLMPVPRPPMFDAGVSAALADLVAKGAGGTLFLETDDCQASYDDLSARGVVFNDPPTPQPYGIDTSFRDPSGNNIRLTQILDFSPDRR

Crispr_ID: NC_014666_15

• CRISPR_ID: NC_014666_15
• CRISPR_location: 6606064-6606135
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_014666_15

Consensus_repeat	Method
CCGGGCTCGGGGCGCTCATGGCGACCG	CRISPRCasFinder

spacers of NC_014666_15

>15.1|6606091|18|NC_014666|CRISPRCasFinder
AGCCCGGGATCGCCGGGC

CRISPR arrays and Neighbor proteins around NC_014666_15

CRISPR arrays

The CRISPR arrays of NC_014666_15

>merge|NC_014666|15|6606064-6606135|CRISPRCasFinder
CCGGGCTCGGGGCGCTCATGGCGACCGAGCCCGGGATCGCCGGGCCCGGGATCGCCGGGCTCGGGGCGCTCG

>NC_014666|15|12|6606064-6606135|CRISPRCasFinder
CCGGGCTCGGGGCGCTCATGGCGACCG	AGCCCGGGATCGCCGGGC
CCGGGATCGCCGGGCTCGGGGCGCTCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_014666.1|WP_013426480.1|6599442_6601872_+|L-carnitine-dehydratase	unknown	unknown	gnl|CDD|367110
NC_014666.1|WP_013426477.1|6596332_6596623_-|DUF1330-domain-containing-protein	unknown	unknown	gnl|CDD|377765
NC_014666.1|WP_013426486.1|6607731_6608463_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228
NC_014666.1|WP_013426487.1|6608565_6609519_+|alcohol-dehydrogenase-catalytic-domain-containing-protein	unknown	unknown	gnl|CDD|176198
NC_014666.1|WP_013426476.1|6596054_6596243_+|ferredoxin	unknown	unknown	gnl|CDD|224064
NC_014666.1|WP_013426489.1|6611375_6612404_+|DUF2889-domain-containing-protein	unknown	unknown	gnl|CDD|378563
NC_014666.1|WP_013426482.1|6602460_6603207_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|212491
NC_014666.1|WP_013426478.1|6596886_6597792_-|LLM-class-F420-dependent-oxidoreductase	unknown	unknown	gnl|CDD|274680
NC_014666.1|WP_013426493.1|6616101_6617391_+|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|380564
NC_014666.1|WP_013426483.1|6603561_6604734_+|acyl-CoA/acyl-ACP-dehydrogenase	unknown	unknown	gnl|CDD|224871
NC_014666.1|WP_013426494.1|6617739_6619020_+|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|380564
NC_014666.1|WP_013426492.1|6614930_6615908_+|NADPH:quinone-oxidoreductase-family-protein	unknown	unknown	gnl|CDD|176203
NC_014666.1|WP_013426481.1|6601945_6602386_-|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl|CDD|379275
NC_014666.1|WP_041259658.1|6594756_6596055_+|cytochrome-P450	unknown	unknown	gnl|CDD|225035
NC_014666.1|WP_083819638.1|6597993_6599277_-|cytochrome-P450	unknown	unknown	gnl|CDD|225035
NC_014666.1|WP_013426488.1|6609515_6609989_+|VOC-family-protein	unknown	unknown	gnl|CDD|372667
NC_014666.1|WP_013426484.1|6604730_6605990_+|acyl-CoA-dehydrogenase	unknown	unknown	gnl|CDD|173841
NC_014666.1|WP_013426490.1|6612515_6613817_+|acyl-CoA-dehydrogenase	unknown	unknown	gnl|CDD|173844
NC_014666.1|WP_049807261.1|6613921_6614926_+|phosphotransferase-family-protein	unknown	unknown	gnl|CDD|270703
NC_014666.1|WP_049807003.1|6619075_6619765_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_014666.1|WP_013426480.1|6599442_6601872_+|L-carnitine-dehydratase	gnl|CDD|367110	pfam02515, CoA_transf_3, CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	1.22352e-75
NC_014666.1|WP_013426477.1|6596332_6596623_-|DUF1330-domain-containing-protein	gnl|CDD|377765	pfam07045, DUF1330, Domain of unknown function (DUF1330). This family consists of several hypothetical bacterial proteins of around 90 residues in length. The function of this family is unknown.	6.1394e-32
NC_014666.1|WP_013426486.1|6607731_6608463_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	9.3497e-07
NC_014666.1|WP_013426487.1|6608565_6609519_+|alcohol-dehydrogenase-catalytic-domain-containing-protein	gnl|CDD|176198	cd08236, sugar_DH, NAD(P)-dependent sugar dehydrogenases. This group contains proteins identified as sorbitol dehydrogenases and other sugar dehydrogenases of the medium-chain dehydrogenase/reductase family (MDR), which includes zinc-dependent alcohol dehydrogenase and related proteins. Sorbitol and aldose reductase are NAD(+) binding proteins of the polyol pathway, which interconverts glucose and fructose. Sorbitol dehydrogenase is tetrameric and has a single catalytic zinc per subunit. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Related proteins include threonine dehydrogenase, formaldehyde dehydrogenase, and butanediol dehydrogenase. The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit. Horse liver alcohol dehydrogenase is a dimeric enzyme and each subunit has two domains. The NAD binding domain is in a Rossmann fold and the catalytic domain contains a zinc ion to which substrates bind. There is a cleft between the domains that closes upon formation of the ternary complex.	1.08396e-52
NC_014666.1|WP_013426476.1|6596054_6596243_+|ferredoxin	gnl|CDD|224064	COG1141, Fer, Ferredoxin [Energy production and conversion].	1.08506e-09
NC_014666.1|WP_013426489.1|6611375_6612404_+|DUF2889-domain-containing-protein	gnl|CDD|378563	pfam11136, DUF2889, Protein of unknown function (DUF2889). This bacterial family of proteins has no known function.	8.2019e-30
NC_014666.1|WP_013426482.1|6602460_6603207_-|SDR-family-oxidoreductase	gnl|CDD|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	1.78589e-67
NC_014666.1|WP_013426478.1|6596886_6597792_-|LLM-class-F420-dependent-oxidoreductase	gnl|CDD|274680	TIGR03619, F420_Rv2161c, probable F420-dependent oxidoreductase, Rv2161c family. Coenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H, Rhodopseudomonas palustris HaA2, and others. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxygenanases (pfam00296), that appear only in F420-positive genomes and are likely to be F420-dependent. This model describes a domain found in a distinctive subset of bacterial luciferase homologs, found only in F420-biosynthesizing members of the Actinobacteria. [Unknown function, Enzymes of unknown specificity].	8.57156e-93
NC_014666.1|WP_013426493.1|6616101_6617391_+|ABC-transporter-substrate-binding-protein	gnl|CDD|380564	cd06341, PBP1_ABC_ligand_binding-like, type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions. This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. Members of this group are sequence-similar to members of the family of ABC-type hydrophobic amino acid transporters such as leucine-isoleucine-valine binding protein (LIVBP); however their ligand specificity has not been determined experimentally.	1.03928e-114
NC_014666.1|WP_013426483.1|6603561_6604734_+|acyl-CoA/acyl-ACP-dehydrogenase	gnl|CDD|224871	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism].	2.44244e-53
NC_014666.1|WP_013426494.1|6617739_6619020_+|ABC-transporter-substrate-binding-protein	gnl|CDD|380564	cd06341, PBP1_ABC_ligand_binding-like, type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions. This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. Members of this group are sequence-similar to members of the family of ABC-type hydrophobic amino acid transporters such as leucine-isoleucine-valine binding protein (LIVBP); however their ligand specificity has not been determined experimentally.	6.58396e-101
NC_014666.1|WP_013426492.1|6614930_6615908_+|NADPH:quinone-oxidoreductase-family-protein	gnl|CDD|176203	cd08241, QOR1, Quinone oxidoreductase (QOR). QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR acts in the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site, and a structural zinc in a lobe of the catalytic domain. NAD(H)-binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	9.56163e-136
NC_014666.1|WP_013426481.1|6601945_6602386_-|nuclear-transport-factor-2-family-protein	gnl|CDD|379275	pfam13577, SnoaL_4, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	1.3339e-31
NC_014666.1|WP_041259658.1|6594756_6596055_+|cytochrome-P450	gnl|CDD|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	2.09893e-69
NC_014666.1|WP_083819638.1|6597993_6599277_-|cytochrome-P450	gnl|CDD|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	5.76662e-83
NC_014666.1|WP_013426488.1|6609515_6609989_+|VOC-family-protein	gnl|CDD|372667	pfam13669, Glyoxalase_4, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily.	9.07368e-13
NC_014666.1|WP_013426484.1|6604730_6605990_+|acyl-CoA-dehydrogenase	gnl|CDD|173841	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26. Putative acyl-CoA dehydrogenases (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	2.96281e-88
NC_014666.1|WP_013426490.1|6612515_6613817_+|acyl-CoA-dehydrogenase	gnl|CDD|173844	cd01155, ACAD_FadE2, Acyl-CoA dehydrogenases similar to fadE2. FadE2-like Acyl-CoA dehydrogenase (ACAD). Acyl-CoA dehydrogenases (ACAD) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACAD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. ACAD's are generally homotetramers and have an active site glutamate at a conserved position.	6.91502e-116
NC_014666.1|WP_049807261.1|6613921_6614926_+|phosphotransferase-family-protein	gnl|CDD|270703	cd05154, ACAD10_11_N-like, N-terminal domain of Acyl-CoA dehydrogenase (ACAD) 10 and 11, and similar proteins. This subfamily is composed of the N-terminal domains of vertebrate ACAD10 and ACAD11, and similar uncharacterized bacterial and eukaryotic proteins. ACADs are a family of flavoproteins that are involved in the beta-oxidation of fatty acyl-CoA derivatives. ACAD deficiency can cause metabolic disorders including muscle fatigue, hypoglycemia, and hepatic lipidosis. There are at least 11 distinct ACADs, some of which show distinct substrate specificities to either straight-chain or branched-chain fatty acids. ACAD10 is widely expressed in human tissues and highly expressed in liver, kidney, pancreas, and spleen. ACAD10 and ACAD11 are both significantly expressed in human brain tissues. They contain a long N-terminal domain with similarity to phosphotransferases with a Protein Kinase fold, which is absent in other ACADs. They may exhibit multiple functions in acyl-CoA oxidation pathways. ACAD11 utilizes substrates with carbon chain lengths of 20 to 26, with optimal activity towards C22CoA. ACAD10 may be associated with an increased risk in type II diabetes. The ACAD10/11-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).	2.65649e-74
NC_014666.1|WP_049807003.1|6619075_6619765_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	5.90825e-07

Protein sequences

>NC_014666.1|WP_013426484.1|6604730_6605990_+|acyl-CoA-dehydrogenase
MTESTESLEEFRARARAWIRANLRPLEANEEVGILRPTRTDEQELAAVARDREIQRMLFDAGLAGLCFPREYGGQGLSYEHQRAFSAEIAGYEYPARLQVPTFAPCAAVLLEFGTEEQKLAHIPAILKGEEIWMQFLSEPSSGSDVAAALTTATRDGDDWILNGSKIWTTGAWWSDWALCLARTNWDVPKHRGLTVFIFPLNSPGVDVQRIEMLNGGMEFCQEFMTDVRVPDTARIGQVDDGWTVGTRWMFHERTYASSPYTISTGGNSIHGVSSSWVLDIARATGGLADSRVRDLVGEGRTLDLVRDALQNRLATGMRSGKMSDQSAAIARLCAGVTSTRLTSLAFDIVGELGAAWSAEDGAGGEVGADFLMRQTATLGGGTTEMARNVISERVLGMPREPSLDRGRAFRDVPRGGRS
>NC_014666.1|WP_013426483.1|6603561_6604734_+|acyl-CoA/acyl-ACP-dehydrogenase
MLLELTPDQEVFREATARFLADRVPPEEIRRLRDDPAGFTPDYWRAGAELGWTSPLVAEEHGGGSISGAGRTDLTILAHEFGACAAPGPLAAANVVMSALSGALALEGSGGEAHLAVLESLLSGGSFATCALGEPGLTLGVPDQVRVQVRADGGDVVLDGLARPVESAAQASHILVTAKVAGSETGFAQVLVPTATPGVTVAPLRTVDLTRRFSVVTFDGVRLPAEAVVGSLGDAAEQIERQFQVAAILACAESVGAMQTSFDTTVRWAFERYSFGRPLASYQELKHRFADMKMWLEASHAICDKAAAAVDAGAPEAAELVTAAKAYIGECSTDLLQDCVQIHGGIGVTFEHDLHFYLRRVTVNRTLFGTPATHRARLAGIFEHLKEQAA
>NC_014666.1|WP_013426482.1|6602460_6603207_-|SDR-family-oxidoreductase
MAGRFEGKVALITGAGSGMGRATTIRLASEGASVLAIDINEGALVETKTLADGPVSLRQVDVGDPAACAEAVAVTVAEFGRLDVLGNVAGIYRPAHTAQTSLELYRQTMAVNLDGPFFLSQAAIPHLLESGGNIVNIASNAGIQGTPYSAAYAASKGGLIQLTRSMAVEFIKTPMRVNAIAPAGTLTNIARDVTFPEDLDPDLARRMAGYRGLTMPEEIAALFAFLASGEARSITGAVYVVDNGLTVS
>NC_014666.1|WP_013426481.1|6601945_6602386_-|nuclear-transport-factor-2-family-protein
MDLQAVSDKLEIQEQLARYARGVDTNDYELWKSVFTPDALIDYTSTSATLPVLRRDEMAAHLEAGLGQMPMKIHYITNVEITLDGDKAKVIAQFFNPMQVPGMAEQSSCGGYYFHDFVRTPDGWKSANLTEKLVWFVNPPSARPTS
>NC_014666.1|WP_013426480.1|6599442_6601872_+|L-carnitine-dehydratase
MTTEPQAPTIPAPHGPLAGVRVVEAAFGTSVVGAGLATSLPGALLRDFGAEVTRVRSTTRSTLDTGIEFDHVWDRGKRVVEVDDADPAAAAAVTELARGADVLFLAGPHEAIERQGLDYPALALLNPRLVVVRLRPGHTARGAVGDLELLLDARLGLLTQIRHHQPGRPAFPDLTVASAGAGLAATVGALAGLYERVGTGRGGWAETSLADGLRALLPMIIGRVEHPSPTTTLLWRDQGPKESLAYRCADGEYLQLWFGAKGAYEAFLAHLGEPPSERGYNADLMSGAMVERGARWAAAFARRPRAEWLAEFAGHNFRCEPVLRPGEALADPHVRQTGLSVTHDDPDHGAVTVLGPIARVTASDPARAGGTRPPAGDGRLLSGVRVLDLSAYLAGPVATAVLAELGADVVKVEPVTGDVHRTMEPMFAAGQRGKRAVALDLKAPGADRVLAALFAGSDVVHHNSRVGLAERLGYDEATVRAANPDAVYCHASGFGATGPRAKLPANDHLMQALSGVEGAQGGAGQPPTFLVWGAIDSASGWVAACGILAGLYARRRGGGGQSVATSLLGAGLMLKSGAFLAGDPSAAAPHVISGPVLDAEQTGYGAAYRLYQAADGGWLALAVPDAAAWRRLRDAVQAGLAVAPAPGSARPATAGRPVPSLAGLPAEPPPLRTAPGDRQPAEEILEAAFAAGGTAAGWVARLRAAGVPAELVAEVDRSGFIANVLDDPVDREIGRTVAFAWGARGRTEQPGFALRLGPAPRPAVRVAIPGLGEHTAEVLAAAGFDADAQATLADAGAIPPSPLPAAARG
>NC_014666.1|WP_083819638.1|6597993_6599277_-|cytochrome-P450
MTCCCHEPEGEPPSRRRRGRRRRVELGLASATADREIYYDPYDVVIDSDPYPVWKRMRDEAPLYYNDAHGFYALSRWDDVDEAIADHDTYISGQGSVLEIIKAGRGVPPGMVLGEDPPIHDLHRALISRVFTPRRMAALEPQVRQLVADTLDQFVGTDGFDFVVDLGAFIPMRVIGMMLGIPESDQAAIRDAGHERHHLEAGQAPKASDPEISMQAFAEYIDWRTNNPSDDLMTALLTVEFTDETGTRRRLSRTEVLIYTALLAGAGNETTRRLIGWTGQLLGDHPDQRRQVAADRDGLVARAVEETLRFEAPSPVQARVLSRDVELYGQTVPAGSALLLLNASANRDERHWPDADSFDLHRAPERHLSFGHGIHFCMGAGLARTEGRVVLDEMLKRWTDWEVDYDNAVLDHTSTTRGWMKLPIRLS
>NC_014666.1|WP_013426478.1|6596886_6597792_-|LLM-class-F420-dependent-oxidoreductase
MRFILHYPETNGTDRDMLDAGPLDEVAAAAEKAGFDALSLTEHPIPGAGWLETGGHQSLDPFVALGFAAAATTRLRLMTNLSVVTYRNPFLLAKAAATVDKLSGGRLILGLGAGYQKSEFFALGVDAAERGALFEEALDVLPLHWKGEPFSYEGRHFNARNVIARPKPVQDPIPIWIGGNTPAARRRAAQKGQGWLPMMAPPSVAVTAQTTAINSRDELAGLIQGVKDAAAAAGRTEPLDFTCSYSDPAIGSSPTVDPDRHREQFAELEKVGATWCIISCHSESRETTLDFIESFGATYLS
>NC_014666.1|WP_013426477.1|6596332_6596623_-|DUF1330-domain-containing-protein
MPKAYVVFTEAINDPDGMAEYSKLAMASFAGHTARPLAVGPATEVLEGEWHGNQTVILEFDSVEEAKAWYTSEAYAKAIPLRQAAADCNAAIITGF
>NC_014666.1|WP_013426476.1|6596054_6596243_+|ferredoxin
MKVFIDDDNCRGHGVCAAECPQVFVVNDDGYGEVIVDEVPAELEDAVRVVATHCPERAITVE
>NC_014666.1|WP_041259658.1|6594756_6596055_+|cytochrome-P450
MANDLESLDFFLGRDLVDDPYPYFDELRSKCPVYREPHHNVLMVTGYDEGVQVLQDVENFSSVTSVTGPFPGFPVPVEGRDDVAELIAQHRDSLPFSDQLPTMDPPTHTDHRALLMKMITPKRLKENEEWMGGITDQLLDTLLERGKGEFVGEFAGPLALLVIADLLGVPPEDHPEFIKQLNRSNVGGGIGSSSGESLAHNPLEFLYGKFAGYIEDRRKEPRGDVLTGLAQATFPDGTTPEVIDVCRVAANLFSAGQETTVRLVSTAAKLIAEDPELQATLRANPEKVPNFLEEVLRTESPIKGDFRMSKCPVSVGGVDVPAGATLMIVNGAANRDPRHFDDPATFDISRANARHHIAFGRGIHTCPGAPLARAEARVAIQRLLERTSDIRLDPGLHGSAENPKYRYMPTFILRGLLFLGLEVTPAQVAVEA
>NC_014666.1|WP_013426486.1|6607731_6608463_+|TetR/AcrR-family-transcriptional-regulator
MTQNADRLLPGGPGHVPAQDHEVPTARDASASPGGKDVAARTAARTLAARTAGYTNEVRRLLDAGLVVVIRNGTSSRPRVADIVAEAGLSNDAFYRHFPSKDALVAALIEDGAERLASYVDHQMSKEPTPAGRVRRWVEAVLAQAMGDVAESTLAVLWNGSGSGDVASGRHPAAGPLAVLLHEPFAALGSEDPALEGSLAAHATLGTLSDHLWRRAEPTEADVERITRFLLRAVSGAPAPDAP
>NC_014666.1|WP_013426487.1|6608565_6609519_+|alcohol-dehydrogenase-catalytic-domain-containing-protein
MKAVRATDGAVAVVELDAPPGIGGELVEMKSASICSSDLMYLRYGLNRVVGHELAGIRADGTAVVVEAVLSCGECDHCRSGRYNLCPTHFTQALGATTDGGMAEQFQIQSNRLIPLPSGLDVRDGSLAEPTAVGWHALRLAHTGPDTSVAVVGAGALGLLAVASAYRQGATEVALEARHPHQVAAGERLGAKIGATGRYDVVLDAAGTMESLARAVELVGPRGRVVSVATHRGPVPIDWSTLFHLEASILPSIGYCMHDRGDGEAVAEIAEAAAMLADNPEIAQTLITHRFPLEDAVEAFRVAGDRASGAIRVVVEL
>NC_014666.1|WP_013426488.1|6609515_6609989_+|VOC-family-protein
MTTLRPENLYHVGIIVEDFESELKRLTELFGYEWCDELVADTNVRIHTADGPVEKTITNRFTYSVNEPRLEIIRPIPGTVWTPSNSGAHHLGYWSDDVVADSAALVALGMPLEVEGVGPDGLPYWTYHRGTQGPRVELVSSAIKPGLEGYWAAGAAR
>NC_014666.1|WP_013426489.1|6611375_6612404_+|DUF2889-domain-containing-protein
MTNDTLTGPAAPDGPATATPPRRPGLVRRTTTHDSLRLSGLRGPVTLDARGRDLRVEPDGSTSILAAQRVMVEVTFPERAIARIDTDPGEPRLGALLGARAASGFRQKVIEALPGEGESRSVRFQLLDDLPTALLISGYALQKQVAPAPFDRERKAAGLTLQYPDLCAGWITGGTIVRGLEETGQVPRPVGPAVGPIAGTDPDGWHEVGPLPAHGMRRRRRLDVWWEPGEPDARVECFFRDSHMDAGGVETALHEYTVHATVDPRSGTFTSCTADFGALPWQECPVALASAGRLVGRRPDGLRRHVRDTFTGISTCTHLNDTLRSLEDVGALIDKLPAHHAG
>NC_014666.1|WP_013426490.1|6612515_6613817_+|acyl-CoA-dehydrogenase
MAWDFETDPEYQKKLDWADEFVRNEVEPLDLAFPDLQFVPLTETRRRLIDPLKQQVRDQGLWATHLGADLGGQGFGQQKLALLNEILGRSSWAPIIFGCQAPDTGNAEIIAHYGTPEQKERYLQPLLDGEMFSSYSMTEPQGGADPTQFTCSAHKEGGEWIINGWKYFSSNARTASFFIVMVVTNPDVSAYRGMSMFLVPSDTPGINIVRNVGLAGEPLGDGMHALIHYEDVRVPESALLGGEGQAFAIAQTRLGGGRIHHAMRTIGQAQRLLDMTCERALSRTTAGSKLAEKQFVQGFIADSYAQLLQFRLLVMYIAWEIDKYQDYKRVRKDIAVAKIVMPTILHDIAWRAMQIHGALGTTNEMPFFKSINGAAVMGLADGPTEVHKVTVAKQVLRDYKPTDGMWPTEWIPAKLEAAQAKYAEFLEHEVGNQ
>NC_014666.1|WP_049807261.1|6613921_6614926_+|phosphotransferase-family-protein
MDTQGLPGAGAPLSSKFLSGGTQNEIYLLTRGDFQCVIRIPPAKAPADRDAGILREWRIIEALDGTDVPHTAAVAVCTDHSVLGRTFYLMGFVDGWSPMNMKDRKWPEPFDSDLDLRQGLGYQLAEGIALLSKVDWQAKGLQDLGRPDGFHERQVDRWTSFFEKIKTRELEGMDVATDWLRNHRPLDYIPGLMHGDYQFANVMFKNEVPAKLAALVDWEMGTVGDPKLDLAWMVMNWPENPLDRDAVKAGYVDHFGMPTRDKIVEHYAKVSGRQVDDLDYYLVLARWKIAIVLERGFARAGNDPKLLAFGPVIEQAMRNAAEFASTTDYKHTGK
>NC_014666.1|WP_013426492.1|6614930_6615908_+|NADPH:quinone-oxidoreductase-family-protein
MKAAVCVEYGGPEVIEVKEIDTPPVGPDQVRVGVRAAAVNFPDVLVIANTYQVKAPVPFVPGSEFAGVVEEVGADVTGLAPGDRVAGTVFVGAFAEQVVCRPESLRPIPDGVDDRSAAAFVVAHRTSYHVLRSMARVQPGERVVVLGAGGGVGLAAVQLAVALGAEVTAVANAADKLQIAAANGATTLLDNTVEDLRKALKVAHPDGVDVVVDMVGGDLSEAALRALRFDGRFVTVGYASGTIPRIPLNLVLLKGAHIMGFQMRDFATHRPDELARDDRELTELLSSGKVRPYIGSVFDLDDTAGALRHVADGKAIGKVVLDVAP
>NC_014666.1|WP_013426493.1|6616101_6617391_+|ABC-transporter-substrate-binding-protein
MAPFRWRSSSRTKAALLAAATGLTMLVACGGPGTTAAAGSCTSSVAGITPTGVKAGMVWSDTGPSAETMRAFRAGVDARIDAANEQGGILGRKVTYAWRDDQADKSLNLHGTQDLVQNEKVFGIIAMPSATSAETSDWLASQGIPVTGLASDASWLGKNNMFSWFYLGDGSVTTWGDYVSHEHGTRAAVIAVSANASNGDFTQQIVASLKAAHITVVRTFAISDTTTNYASLAQQIKAAGIDSLAGVLLPDAAAQLIPALKEVGLNLGQSLKVAQMPLGYDPTVLAKYGRTLAGVSVATAIRPFEEGAPGQRAFTSAMELYAPEIQPPTQDSAVDGWISADLFIRGLRAAGACPTRQSFISGLRAVKDYDGAGMSPLAKNDLSANYKQTTSCYYFLKISQDGAAFQPQNGGQPFCGSPISPAEVAAANQ
>NC_014666.1|WP_013426494.1|6617739_6619020_+|ABC-transporter-substrate-binding-protein
MSSPGRSRLVRAGALAVIATSLAAGLAGCGSSGSATSAASCSTQVPGITSTTVNAGLLWSDSGDGASSMPDFRSGVDARFGLANESGGVFGRTVSYAWRDDQSSQDLNLLGAQDLVGRGHVFGIIEAPGASNGSITWLNQQNIPVTGLASDPGWVGRNNMFSFYYLSDGSSTVWGDVINAAGASRAAVLEVSGNKSNSDFSRQYEASLLESGVKIVREFQIAEAVTNYQAVAKQLKQDDIDALVGVLLPSTAAKLIPAARSLGVNLKITMMPLGYDPAVLASSGKAIAGTIIFTEVQPWLDTPRQQTFEAAMAKYAPEIQSVRSDSAVDGFVAADIFIRGLQAAGKCPTRESFISGLRAVTNYDGFGLVPAPVNFATNLKAPQSCYNFIQVRADGSAFDPMFGGQARCGRPISSARMNQLLDPGSS
>NC_014666.1|WP_049807003.1|6619075_6619765_-|TetR/AcrR-family-transcriptional-regulator
MAQDQELAVSTLSEEPAWKQRAVERSTKAARLRAERKVQQFLEAAQEIIVAKGSTDFTVQEVVDRSHQSLRSFYQHFGGKHELLLALFENALRRSADEIRAAATSEVDPLAGLELAVRMLFASSLPGPESSHPLFTDFATQLLVSYPAEVRSAHEPMLTLFAELMGRVDATGQLRTELRPRRAAAMVMQSVMFLAQSTAVVADSEGAHPLTGDEVWNFCAGGFVRPLAG

Crispr_ID: NC_014666_16

• CRISPR_ID: NC_014666_16
• CRISPR_location: 7298537-7298656
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_014666_16

Consensus_repeat	Method
CTCCGCGAGGCGCGCCTCCGCGCCCGCGTGGTC	CRISPRCasFinder

spacers of NC_014666_16

>16.1|7298570|54|NC_014666|CRISPRCasFinder
GCCCGCCGCTGCACCTCGCCAGAAGACAACCACCCTCGGCGCGTCAGGGCGGGG

CRISPR arrays and Neighbor proteins around NC_014666_16

CRISPR arrays

The CRISPR arrays of NC_014666_16

>merge|NC_014666|16|7298537-7298656|CRISPRCasFinder
CTCCGCGAGGCGCGCCTCCGCGCCCGCGTGGTCGCCCGCCGCTGCACCTCGCCAGAAGACAACCACCCTCGGCGCGTCAGGGCGGGGCTCCGCGAGGTGCGCCTCCGCGCCCGCGTGGTC

>NC_014666|16|13|7298537-7298656|CRISPRCasFinder
CTCCGCGAGGCGCGCCTCCGCGCCCGCGTGGTC	GCCCGCCGCTGCACCTCGCCAGAAGACAACCACCCTCGGCGCGTCAGGGCGGGG
CTCCGCGAGGTGCGCCTCCGCGCCCGCGTGGTC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_014666.1|WP_013427035.1|7301405_7303106_-|WD40-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|238121
NC_014666.1|WP_013427023.1|7285043_7286273_-|squalene-synthase-HpnC	unknown	unknown	gnl|CDD|274592
NC_014666.1|WP_013427033.1|7298709_7299549_-|apolipoprotein-acyltransferase	unknown	unknown	gnl|CDD|143592
NC_014666.1|WP_013427025.1|7288156_7289491_-|aspartate-aminotransferase-family-protein	unknown	unknown	gnl|CDD|235687
NC_014666.1|WP_013427027.1|7291129_7291978_-|ABC-transporter-permease-subunit	unknown	unknown	gnl|CDD|223673
NC_014666.1|WP_013427031.1|7295324_7296815_-|CoA-acylating-methylmalonate-semialdehyde-dehydrogenase	unknown	unknown	gnl|CDD|143404
NC_014666.1|WP_013427042.1|7312705_7313002_+|DUF397-domain-containing-protein	unknown	unknown	gnl|CDD|377231
NC_014666.1|WP_013427029.1|7292963_7293992_-|ABC-transporter-permease-subunit	unknown	unknown	gnl|CDD|223673
NC_014666.1|WP_013427026.1|7289769_7290912_-|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|378117
NC_014666.1|WP_013427028.1|7291974_7292967_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|213260
NC_014666.1|WP_013427024.1|7286449_7287280_-|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|223377
NC_014666.1|WP_013427037.1|7304851_7306729_-|response-regulator	unknown	unknown	gnl|CDD|381126
NC_014666.1|WP_013427030.1|7293988_7295044_-|TIGR03842-family-LLM-class-F420-dependent-oxidoreductase	unknown	unknown	gnl|CDD|163554
NC_014666.1|WP_157735082.1|7308297_7309353_-|protein-phosphatase	unknown	unknown	gnl|CDD|274963
NC_014666.1|WP_013427041.1|7310146_7312366_-|protein-kinase	unknown	unknown	gnl|CDD|238121
NC_014666.1|WP_041261719.1|7296980_7298387_-|dihydropyrimidinase	unknown	unknown	gnl|CDD|236240
NC_014666.1|WP_013427038.1|7307213_7308251_+|aquaporin-Z	unknown	unknown	gnl|CDD|235453
NC_014666.1|WP_013427034.1|7299868_7301209_+|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl|CDD|185378
NC_014666.1|WP_041261722.1|7303356_7304763_-|histidine-kinase	unknown	unknown	gnl|CDD|340419
NC_014666.1|WP_013427040.1|7309327_7310101_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_014666.1|WP_013427035.1|7301405_7303106_-|WD40-repeat-domain-containing-protein	gnl|CDD|238121	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.	4.53447e-47
NC_014666.1|WP_013427023.1|7285043_7286273_-|squalene-synthase-HpnC	gnl|CDD|274592	TIGR03464, HpnC, squalene synthase HpnC. This family of genes are members of a superfamily (pfam00494) of phytoene and squalene synthases which catalyze the head-t0-head condensation of polyisoprene pyrophosphates. The genes of this family are often found in the same genetic locus with squalene-hopene cyclase genes, and are never associated with genes for the metabolism of phytoene. In the organisms Zymomonas mobilis and Bradyrhizobium japonicum these genes have been characterized as squalene synthases (farnesyl-pyrophosphate ligases). Often, these genes appear in tandem with the HpnD gene which appears to have resulted from an ancient gene duplication event. Presumably these proteins form a heteromeric complex, but this has not yet been experimentally demonstrated.	1.38109e-101
NC_014666.1|WP_013427033.1|7298709_7299549_-|apolipoprotein-acyltransferase	gnl|CDD|143592	cd07568, ML_beta-AS_like, mammalian-like beta-alanine synthase (beta-AS) and similar proteins (class 5 nitrilases). This family includes mammalian-like beta-AS (EC 3.5.1.6, also known as beta-ureidopropionase or N-carbamoyl-beta-alanine amidohydrolase). This enzyme catalyzes the third and final step in the catabolic pyrimidine catabolic pathway responsible for the degradation of uracil and thymine, the hydrolysis of N-carbamyl-beta-alanine and N-carbamyl-beta-aminoisobutyrate to the beta-amino acids, beta-alanine and beta-aminoisobutyrate respectively. This family belongs to a larger nitrilase superfamily comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), this subgroup corresponds to class 5. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer. Beta-ASs from this subgroup are found in various oligomeric states, dimer (human), hexamer (calf liver), decamer (Arabidopsis and Zea mays), and in the case of Drosophila melanogaster beta-AS, as a homooctamer assembled as a left-handed helical turn, with the possibility of higher order oligomers formed by adding dimers at either end. Rat beta-AS changes its oligomeric state (hexamer, trimer, dodecamer) in response to allosteric effectors. Eukaryotic Saccharomyces kluyveri beta-AS belongs to a different superfamily.	1.10399e-162
NC_014666.1|WP_013427025.1|7288156_7289491_-|aspartate-aminotransferase-family-protein	gnl|CDD|235687	PRK06062, PRK06062, hypothetical protein; Provisional.	0
NC_014666.1|WP_013427027.1|7291129_7291978_-|ABC-transporter-permease-subunit	gnl|CDD|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	8.15331e-49
NC_014666.1|WP_013427031.1|7295324_7296815_-|CoA-acylating-methylmalonate-semialdehyde-dehydrogenase	gnl|CDD|143404	cd07085, ALDH_F6_MMSDH, Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2. Methylmalonate semialdehyde dehydrogenase (MMSDH, EC=1.2.1.27) [acylating] from Bacillus subtilis is involved in valine metabolism and catalyses the NAD+- and CoA-dependent oxidation of methylmalonate semialdehyde into propionyl-CoA. Mitochondrial human MMSDH ALDH6A1 and Arabidopsis MMSDH ALDH6B2 are also present in this CD.	0
NC_014666.1|WP_013427042.1|7312705_7313002_+|DUF397-domain-containing-protein	gnl|CDD|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	2.6854e-20
NC_014666.1|WP_013427029.1|7292963_7293992_-|ABC-transporter-permease-subunit	gnl|CDD|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	6.21459e-36
NC_014666.1|WP_013427026.1|7289769_7290912_-|ABC-transporter-substrate-binding-protein	gnl|CDD|378117	pfam09084, NMT1, NMT1/THI5 like. This family contains the NMT1 and THI5 proteins. These proteins are proposed to be required for the biosynthesis of the pyrimidine moiety of thiamine. They are regulated by thiamine. The protein adopts a fold related to the periplasmic binding protein (PBP) family. Both pyridoxal-5'-phosphate (PLP) and an iron atom are bound to the protein suggesting numerous residues of the active site necessary for HMP-P biosynthesis. The yeast protein is a dimer and, although exceptionally using PLP as a substrate, has notable similarities with enzymes dependent on this molecule as a cofactor.	2.137e-34
NC_014666.1|WP_013427028.1|7291974_7292967_-|ABC-transporter-ATP-binding-protein	gnl|CDD|213260	cd03293, ABC_NrtD_SsuB_transporters, ATP-binding cassette domain of the nitrate and sulfonate transporters. NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	4.2884e-114
NC_014666.1|WP_013427024.1|7286449_7287280_-|SDR-family-NAD(P)-dependent-oxidoreductase	gnl|CDD|223377	COG0300, DltE, Short-chain dehydrogenases of various substrate specificities [General function prediction only].	3.01181e-53
NC_014666.1|WP_013427037.1|7304851_7306729_-|response-regulator	gnl|CDD|381126	cd17595, REC_TrxB, phosphoacceptor receiver (REC) domain a fused response regulator with a thioredoxin reductase output domain. This family is composed of uncharacterized fusion proteins containing a REC domain and a thioredoxin reductase domain. Thioredoxin reductase catalyzes the reduction of thioredoxin and is thus a central component in the thioredoxin system. Fusion proteins containing REC and thioredoxin reductase domains could play an important role in the environmental regulation of the cellular dithiol-disulfide ratio. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	8.16688e-75
NC_014666.1|WP_013427030.1|7293988_7295044_-|TIGR03842-family-LLM-class-F420-dependent-oxidoreductase	gnl|CDD|163554	TIGR03842, F420_CPS_4043, F420-dependent oxidoreductase, CPS_4043 family. This model represents a family of putative F420-dependent oxidoreductases, fairly closely related to 5,10-methylenetetrahydromethanopterin reductase (mer, TIGR03555), both within the bacterial luciferase-like monoxygenase (LLM) family. A fairly deep split (to about 40 % sequence identity) in the present family separates a strictly Actinobacterial clade from an alpha/beta/gamma-proteobacterial clade, in which the member is often the only apparent F420-dependent LLM family member. The specific function, and whether Actinobacterial and Proteobacterial clades differ in function, are unknown. [Unknown function, Enzymes of unknown specificity].	0
NC_014666.1|WP_157735082.1|7308297_7309353_-|protein-phosphatase	gnl|CDD|274963	TIGR04075, Ser/Thr_phosphatase_family_protein, polynucleotide kinase-phosphatase. Members of this protein family are the bacterial polynucleotide kinase-phosphatase (Pnkp) whose genes occur paired with genes for the 3' terminal RNA ribose 2'-O-methyltransferase Hen1. All members of the seed alignment belong to a cassette with the Hen1. The pair acts in bacterial RNA repair. This enzyme performs end-healing reactions on broken RNA, preparing from the RNA ligase to close the break. The working hypothesis is that the combination of Pnkp (RNA repair) and Hen1 (RNA modification) serves to first repair RNA damage from ribotoxins and then perform a modification that prevents the damage from recurring. [Transcription, RNA processing].	7.54259e-133
NC_014666.1|WP_013427041.1|7310146_7312366_-|protein-kinase	gnl|CDD|238121	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.	4.29166e-72
NC_014666.1|WP_041261719.1|7296980_7298387_-|dihydropyrimidinase	gnl|CDD|236240	PRK08323, PRK08323, phenylhydantoinase; Validated.	0
NC_014666.1|WP_013427038.1|7307213_7308251_+|aquaporin-Z	gnl|CDD|235453	PRK05420, PRK05420, aquaporin Z; Provisional.	2.88454e-87
NC_014666.1|WP_013427034.1|7299868_7301209_+|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	gnl|CDD|185378	PRK15481, PRK15481, transcriptional regulatory protein PtsJ; Provisional.	3.11536e-68
NC_014666.1|WP_041261722.1|7303356_7304763_-|histidine-kinase	gnl|CDD|340419	cd16943, HATPase_AtoS-like, Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS. This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.	6.98492e-44

Protein sequences

>NC_014666.1|WP_041261719.1|7296980_7298387_-|dihydropyrimidinase
MKTLITGGTVVGPLGATPQDVLVDGETIAALYAPGAAAGVTADTMIDATGRYVVPGGVDVHTHMKLPFGGTFASDDFASGTKAAAWGGTTTIIDFAVQRTGEVVQDGLAAWHALADGNCAIDYGFHMIMGGVDDDALKAMDYLVAHEGITSFKLFMAYPGVFYSDDGQILRAMQKATDNGALIMMHAENGIAIDVLAAQAVARGQTDPIYHGITRPSALEGEATHRATVLAQVAGNTPLYFVHMSASEALAHVSAARSAGRNVFAETCPQYLYLTLEDQLGAPGFEGAKWVASPPLRPRDEPHRDDLWRGLRTDDLAVVSTDHCPFCFKDQKELGRGNFTKIPNGMGTVEHRMDLVYQGVATGKLSLERWVETCSTTPARMFGLYPKKGVIQPGSDADIVLYDPRATTTISAATHHMNIDHSAWEGFEIAGKVETVLSRGSVVVADGAFHGRSGHGQFLRRGLSQYLR
>NC_014666.1|WP_013427031.1|7295324_7296815_-|CoA-acylating-methylmalonate-semialdehyde-dehydrogenase
MREIGHWIDGKAVAGGSGRFGPVWNPATGEQAAQVALASLEEINAAVASAKAAFTGWRSTGLGRRAEVMFRFRELLYANRTELAKLITAEHGKTVDDALGEIARGLENVEFACGAPSLLRGGFSEQVSTGVDVHEIRQPLGVVAGITPFNFPAMVPLWMLSNALACGNAFILKPSERDPSASLLLAELLAQAGVPDGVFTVLQGDKLAVDTLLTHPDVEALSFVGSTPIARYVYETGTAAGKRVQALGGAKNHMIVLPDADIAAAADAAVSAGYGSAGERCMAVSVVAAVGDSADPLVEAIAERVRKIKVGPGLDPDSEMGPVITREARDRVAGYLETAKTDGATLVIDGRDDPISSGPGFFLAPSLIDNVSTTSTVYTDEIFGPVLAVVRCETYTEAVKLVEDNPYGNGVAIYTRDGGAARRFTFDVQAGMVGVNVPIPVPVSYYSFGGWKASLFGDLHMYGPDGIRFYTKTKVVTTRWPDPATSSVELGFPRTR
>NC_014666.1|WP_013427030.1|7293988_7295044_-|TIGR03842-family-LLM-class-F420-dependent-oxidoreductase
MDIGVVLQTNPPASRVVELARQAETLGFSHVWTFDSHLLWEEPFVIYSQILAATRKVLVGPMVTNPATRDWTVTASLFATLNEMYGNRTICGIGRGDSAVRVLNGKPTTLATLRDCVGVVRELANGREAEVNGTKLRFPWGLDSRLDIWVAGYGPKALALAGEIGDGFILQLADPDITAWTIDAVRTAAAAAGRDPATVKICVAAPAYVGPGDAASLAHQRDQCRWFGGMVGNHVADLVGRYGAGGSAIPAALTSYIEGRTGYDYNEHGRAGNTHTAFVPDEIVDRFCLLGPAEAHVRRLTELAALGVDQFAVYLQHDAKLATLEAYGEQVIPAIAEHIRAKSPAAGPEAP
>NC_014666.1|WP_013427029.1|7292963_7293992_-|ABC-transporter-permease-subunit
MTITASIDESAATAALGGRDAAPPVPAVGGWGERLRRAGLAVVAVVLVCAVWELYKLVGSPHGGRVLGVPVLPRNDDVSMPHVWSVLAQLGHQEVAADGSQTVGLAVLKGIWYTLRVAVVGLLAGVVVGVLLAVLMARLRIVERGLLPYIIASQTVPLIALAPLVAGWSGQLHLGALRWQDWMTVSLIAAYLAFFPVAIGMLRGLQSPAASSVELMRSYAASWWQTLLRLRLPASVPFLLPALRLAAASAVIGAIVAEISTGTSGGVGRLIIAYSQSATSDSTKLYDAVLGAAVTGLLVAGLVSLVELALTRRPGQPRPGTGRAGSGPASDVPSPKTQKVTT
>NC_014666.1|WP_013427028.1|7291974_7292967_-|ABC-transporter-ATP-binding-protein
MTARPAGGPPGSSAVETSPGAPAADAPAAPVPREEDRPAGGANPAAAVPAVAVHGVDKVFPVAGGGATVALAGIELTVAPGEFVSLIGPSGCGKSTLLRLVGDLVEPTRGEVLVFGEPARAARAARRYGIAFQQAGLLEWRTVAGNVELPLQVHGVSRKERRARARELLDLVGLGDFAGHWPAQLSGGMQQRVAIARALAEHPPLLLLDEPFGALDEMTRERMQSELARIRWETGTTVILVTHSIPEAVFLSDRVAVMSPRPGRITDIIDVDLPGRLGAARVGDGVPAGPAAPGETGGPTAVDADDVREQAAFFAAVTAVREALRAGGGA
>NC_014666.1|WP_013427027.1|7291129_7291978_-|ABC-transporter-permease-subunit
MSPAPDGAGPAAGRDRDATRLARWTRARLAVVLPPVVVGVVGLAAWEGYVRANHIQPYLLPAPSEIWTQFRHSFRVIVQTSRATGANAVVGLAVGLVAGLLAAVVAARSKIADGLLGPLAAAMNAVPIIALAPLFNTMFSTTSAVPRRLVVAIVVFFPVFVNTVRGLRQVPDVQRELMRSLAVGPWRFARTVQLPGAVPYIFTGFRLASSLAVIAAVVSEYFGGRQNGLGSRITSAASNTAYPRAWAFVAAACVLGLVVYLVAGLLEWLATPWRRGGRSLTL
>NC_014666.1|WP_013427026.1|7289769_7290912_-|ABC-transporter-substrate-binding-protein
MKRRLAGGLAAGLAVALALAACGSSSGGGSTGSTSSGLTPVKLQLQWFTQAQFAGYIAAEKKGYYKDAGLDVKILEGGTDIVPQTVLAQGKADYAIAWVPKALASREQGAQITDVAQIFQRSGTLQVSFKDKNITGPAALKGKKVGDWGFGNEYELFAGMTKAGVDPSKDITLVQQQFDMKGLISGDVDAAQAMSYNEYAQVLEATNPATGKLYQPSDFNVINWNDVGTAMLQDAIWANTSKLQSDKKYQDTTTKFVEASIKGWIYCRDNAADCRDLVVAAGSKLGASHQLWQTNEVNKLIWPSPNGIGLVDKAAWDQTVSVAKGTKNADGQTVLTKDPEGLAYTNDYVNKALADLKGSGVDVVGSGFKPQTVTLAANGA
>NC_014666.1|WP_013427025.1|7288156_7289491_-|aspartate-aminotransferase-family-protein
MTSSTYDDDRKHVFHSWSAQAALTPLVVNRAEGSCFWDESGRRYLDFSSQLVNANIGHQHPKVIEAIIEQAGKLTTIAPFHANEARSEAARLIASHAPGDLDKVFFTNGGAEATENAVRMARLVTDRHKILTTYRSYHGATGGSIVLTGEPRRWASEPGIPGVVHFHGPYPYRSPFYADSVEQEGERALAHLAEVIALEGPQTVAAVLLETVVGTNGILVPPDGYLAGVRELCDRHGILLILDEVMSGFGRCGEWFAADHWNVVPDLICFAKGVNSGYVPLGGVIMGPKVADAFATRPYPGGLTYSGHPLACAAAVGSIRAFEEEGIVEHARMLGTDVIGPELAKLAVNHPSVGEVRGLGVFWAIELVRDRETREPLVPFNAAGPDAAPMAAFIGACKERGLWPFTHFNRTHVVPPCTITVDELREGLAILDDALTVADSYYTG
>NC_014666.1|WP_013427024.1|7286449_7287280_-|SDR-family-NAD(P)-dependent-oxidoreductase
MSTRSRPAVQDRASRPVISRARAAASAPWPPRTALVTGASSGIGRAAALRLAQDGTKTLLVGRNGVALDEVAAATGGHRFATDLTAVGAETAVASRATELLGDVDLLVLSAGIGAAGPFEVMSPNALRDLVTVNVLAPMMLVRAVLPAMLDRGEGRILLVGSVAGALGVRGEVAYSASKAALVGFADALRSEVRGRGIVVTLCLPGAVDTPFFHRRGAPYVRRWPKAMPPSRVADRMLAGVARGSAEVWVPGWMSLAARVHGAAPPLYRRLANVFG
>NC_014666.1|WP_013427023.1|7285043_7286273_-|squalene-synthase-HpnC
MTPIDARTAAPGRRAEPAGITDIATSTDEVLRAAYGENFPVSPVVLPAAIREHFKAIYGFARLVDDIGDEAPGDRLALLDELAADLERIWTGAGPSLPVHQRLATTVAACDLPAEPFLRLIEANRLDQRVTRYPTFDDLLRYCTLSADPIGRMVLGVLGRATPDRLILSDRVCTALQIAEHLQDVAEDYAAGRIYLPLEDLDTFGVAESDLAAPTASPALRNLMAFQVARATTVLDQGAPLASLLDGRMRLAIAGFIGGGRAALHAVRQAGYDVLGGAPKASKPRLAGAAMWVAVRSYSPSMRAGAAGAGGLPPLCEPPPPSPNPPRATAASAVSAAAVTEPALATAKDRAATSVPAPTVAVTTLSGVVTGADLGNTESRSVNGPASAWPAMTEADSRHSRRGDEGEAS
>NC_014666.1|WP_013427033.1|7298709_7299549_-|apolipoprotein-acyltransferase
MSRVIRAALVQAKWTGDKESMIKAHEDYLRSAAEQGAKVMCFQELFYGPYFCQVQDPVYYEYAEAVPGPTVERFQALCAELGVVLVLPVYEQEQPGVLYNTAAVIDADGSYLGKYRKTHIPHTTGFWEKFYFRPGNLGYPVFDTAVGRVGVYICYDRHFPEGWRALGLNGAELVFNPSATSRGLSNYLWKLEQPAAAVANEYFIGAINRVGIEDLGDDDFYGTSYFVDPEGKFVGGTADPHEPELMVRDLDLDLLTTVRNRWAFYRDRRPDQYGDLTAP
>NC_014666.1|WP_013427034.1|7299868_7301209_+|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme
MLGTITAAVEDRSARGIAGTVSRLVMAGALPAGTRLPTVRELATELGISPTTVSQAWRTLARAGVIAPRGRAGTFVLAGPAAAADPRRYRRITRSPGRLPHDYSTGTPDAALLPDLAPVLARVAQGGNLTLSYLDDPVLPALEKALRIRWPFPPAALTVVDGAMDGLDRVTRELVGFGSRVLVENPCFPPLLDLLDAVGAEVVALPLDDEGVRPEALRAALGAATGAEPVALFLQPRAQNPTGVSMTARRAEQLAGLLAGRAVTVVEDDHSGDVATARPISLGQHLPGSTVHIHSFSKSHGPDLRLAAVGGVESVVTGLATRRMLGPGWSSRLLQAVLAELLGDDDTERTLAHARAVYARRREAMTAALTARGVRAQAPDGINLWMEVADEQVALVSLAARGIGAAPGTPFEAAPLGPHHLRVTVGLIPDEDLEAVADLLAEAARG
>NC_014666.1|WP_013427035.1|7301405_7303106_-|WD40-repeat-domain-containing-protein
MARFGGPAAEGGRGKCLTTVTAAVFQLRNVAIRGASVVGDYGRQGRPDDTVSSGWTTSWRSSRGDRAELDLQLSSHEQSVLVGELARLYPNELAARPLLEGHLNLSMSRLPSFGVGGRAAEVWWAIIQDLAAGKSRVSAPLRKLLVAALIDYPSNGPLMGLAHYHRVPITVAPPTRRGPGEKPRYEPAGRPSGWGRPQILSAAAAAVAIVLGVTIGLITIHPGSGHANTPKSSASATPATFRAVGQPLTDAGGEVWWVSVTPNGRTLAAASEKGTVPIWDVSRPAKPSLLTSLRAGDGQGVTEGTMSVAFAPGGLTLATGSRNGTVQLWNTSDPSSVQPRGGPLVGATDNDPVWVVGFTPAGNLLVSGDHKHMLRMWNVSDPNNPVPLGGPFDGTSGEVWSVGFTPDGSLLATGGQDGSVGLWDTSNPHQQPHLVGKLPIQTTTGTKAIESVSFTPDGRTLATASIDKWVRLWDVSIPSSPRLLIAMGQPGEMWAAAFSRDGQTLAAAGTDGAIRLWDVSHPESPKAFDKALTGHNDTVTKLAFFPDGHTLVSSSRDGTVQLWATG
>NC_014666.1|WP_041261722.1|7303356_7304763_-|histidine-kinase
MDELRTLFLFEKLDEDKLAWLCERGRVVEVEPGDLTVEGEPSRYLFVLLEGEVAILKRVSGVDVEVNRTGHRGVYGGAWNAYLGDRVPQTYPQSMRATRRSRLFVLEAEQFSFLMRDWFPMAVHLLEGLFFGMRGVQEAVSQRERLLALGALSAGLTHELNNPAAAAVRATAGLRERVAGMRHKLGLIAAGIYDKSVLVTLIRLQEEAAERVAKKATQLSPLEASDREDELGDWFDDHGIGFGWDVAPVFVQAGLDVPWLDQVAELVGGEHLGSAVRWLGYTVETELLMNEIEDSTTRVSTLVGAARQYSQLDRGPFQTVDLHELLDSTLVMLARKIDGIQVVKDYDRSIAPIGVYAAELNQVWTNLVDNALGAMAGTDGGTLTIRTWESDGSVFVEIGDTGPGIPADIQGRIFEPFFTTKPVGEGTGLGLDISWRIVVNKHHGDLRVSNSEPGDTRFEVRLPRTPPS
>NC_014666.1|WP_013427037.1|7304851_7306729_-|response-regulator
MTETDPLAGTDLATGTATQPTQSGAIRPAILTVDDDPSVSRAVARDLRRRFGERYRILRAESGQQALDTLRELKLRGGQVSVMIADYRMPGLTGIEFLEQAMDLYPDAKRVLLTAYADTSAAIDAINLVDLDHYLLKPWNPPEEKLYPVLDGLLDAWCRSERRAVVETKVVGDRWSARSYEVREFLARNQVPYRWYLADEPEGRRLLAAAAPAAVSAPSNGSASSNGSMSTDGPRLSDASGLLDGSEPLDGPAPHGQPWPSSLAAAALPVVITPAGAALIDPTDAQIAAEVGLRTIPDENFYDVIIIGGGPAGLGSAVYAASEGLRTVLIERTATGGQAGQSSRIENYLGFPDGVSGAQLTDRARRQAVKFSAEVITAREIVELRADGPARTVRFADGGELSAHTVVLATGVAYRQLPAPGLAELTGRGVYYGAALTEAAGCVGEDIYVVGGANSAGQAAVYLSRHARTVTMLVRGRSLTASMSHYLIEQIAAVPNIVVRTCTEVIAGEGDEHLSALTLRDSGTGVTESVPASRLFVFIGAAPRTDWLDGVVERDGHGFVVAGPDLVAGGRRPSGWTLERDPFHLETSLPGVFVAGDARSESVKRVASAVGEGAMAITLVHRYLS
>NC_014666.1|WP_013427038.1|7307213_7308251_+|aquaporin-Z
MAVKAGTAGEAGTAREARADAASSAEENRRRVRKLAAEAIGTFLLVLGGVGTAVLAGDFMGTLGVALAFGLTLVVLMYVIGPVSGCHVNPAVTIGLCAAKKIAPKDAVAYIVAQCVGAIVAAAAIYLIADAGPFGYSARMQGLGANGYGAHSPAGFGLGGAFLAEVLLTGLLVFTCLGATHIQAPVGFAGIAIGFVLAVCNLVSIPVDNTGVNPARSLGPAVFAGGWALSQLWLFIVAPIVGALVAAAVHRVLRPEPGVRLSTAARALPSESEARIAQETARLLKMPVGAPRHLADGRRAPAGAEDPAKVGAGSAAGRPGRGPDGFRDRDWNRDQDQPGDDTGGC
>NC_014666.1|WP_157735082.1|7308297_7309353_-|protein-phosphatase
MAAVPWVAIPSNSRLDVHGRCAPFAYPARRLWGTGGRSRQKWRVPQPVRGIARSPAGKNDSVPEPRSAAGVAGTAVSVVPAPVDRSAERGPFDVIGDVHGCSEELEELLARLGYELDRDPAGRAVGARHPAGRRVVFVGDLIDRGPHPAAVLRLAMGMAAAGDALAVAGNHEHKLVRALNGSGGSGGPGEPGGPAKVGQHLARTLEQLATEPVEFQEAVLAFCAGLGSHLVLDGGWLVVAHAGLKESYHGLDSARVRSFALFGDTTGERDEYGFPVRRPWANDYRGRAMVLYGHTPGTQHRWVNNTLCLDTGCCFGGALTAVRYPERDQLRVPARRVYHPPTRPLHDMPAA
>NC_014666.1|WP_013427040.1|7309327_7310101_+|hypothetical-protein
MATQGTAAKPAAAHERWVLAYEHGPARRRPPVGTRLPVGRSVEVGRERELSLGVEVTSDGISRVAVVVTATEAGWDLDLRNANGATLHAWGQPPQQISGHQSIAWPRVAIRFHNGQRFDQPHTSYHWVLLEADLLDITPAGPRPGSRTSSATVTPAPPGPLSRPQEDAVRMVFEPLLAWPPQVPAEPLQLKQVASRLGISEAGVRDRLGHAHDRALRLGLHHNVGLNNPEYLYVLVSNGYLAPPTGRNHRVALPWLE
>NC_014666.1|WP_013427041.1|7310146_7312366_-|protein-kinase
MHPGDPLSDGDFWVGPAAAPDKYRLVEQVGKGGEGEVWRAVLPLSAAGRTTVAIKIMPARPGDEAEWEQTDRLLSTLHHPGLVRVTDVFTGPGQHRAGLADASTRSGYVVMDFVEGLTLREWYNEHPDTRISDRIRKLRNVAGALDEMHSGRATNVPVAHGDVKPANIVVREDGGTVLVDLGLARLTDATGASGRSAPYAAPEMRVPGAMATPSADWYAFAATTAQVLLGARLPMTPEGWLDERLLAERLHRDPLTARRPALIQHIQDTLASPPQARTGSLALWLDAALDTLSQKTLTEGGTPTPSYPPAPSPAGAGPFDDGRELGTTQPDPGPEPSPPGPRRADEAATRVGRDQADVFSLSTPASAARPRRGRPVWAVPAAIGAAVLLLVGVTLGVVEFGGRSGSTADAAGPARGPVPSIAAPVPFHPLGKPLVGHTDRVEGVAYSPDGRTLASGGDDGTVHLWDVSRPGAPRDLGRVTGHTAAVDAVAFSRDGRTLASSGEDHTVRLWDVSQPSSARFLTALTADTGPVWALAFSPDRRTLATGSEDHTVRLWDVSNPAAPTELGGPLTEPNQVWSVTFSHDGHILATGNHDGHVRFYDVTNWQNPVMLSSPLAHTKPVLSAVFAPNGHILASASTDHLVRLWDVSNPAAPIPLGNPLILPNEAWTVTFTPDGRTLAVGGADNAVRLWNVQDPTQPTPIGSPLVGHSNTVTGVAFSPDGRTLASSSWDYSVRLWQAR
>NC_014666.1|WP_013427042.1|7312705_7313002_+|DUF397-domain-containing-protein
MSTDQPISSGPCREDGAEAEGGATDSAAWAWRRASFCGPEANACVDVAFGPAAVAVRDSKDPSGPVLLFTTAEWAGFLSGVHNGEFELPHRELELPVC

Crispr_ID: NC_014666_17

• CRISPR_ID: NC_014666_17
• CRISPR_location: 8447831-8447975
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_014666_17

Consensus_repeat	Method
CCGCTCGCTTGCTCCTGCGCTCACGGCGTCCCGGGTTCGCTCCGTCGCCGCACTC	CRISPRCasFinder

spacers of NC_014666_17

>17.1|8447886|35|NC_014666|CRISPRCasFinder
CCTACGGCCTCGTCCTCGTCCCTCGGACGAGACCT

CRISPR arrays and Neighbor proteins around NC_014666_17

CRISPR arrays

The CRISPR arrays of NC_014666_17

>merge|NC_014666|17|8447831-8447975|CRISPRCasFinder
CCGCTCGCTTGCTCCTGCGCTCACGGCGTCCCGGGTTCGCTCCGTCGCCGCACTCCCTACGGCCTCGTCCTCGTCCCTCGGACGAGACCTCCGCTCGCTTGCTCCTGCGCTCACGGCATCCCGGGTTCGCTCCGTCGCCGCACTC

>NC_014666|17|14|8447831-8447975|CRISPRCasFinder
CCGCTCGCTTGCTCCTGCGCTCACGGCGTCCCGGGTTCGCTCCGTCGCCGCACTC	CCTACGGCCTCGTCCTCGTCCCTCGGACGAGACCT
CCGCTCGCTTGCTCCTGCGCTCACGGCATCCCGGGTTCGCTCCGTCGCCGCACTC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_014666.1|WP_041262164.1|8458771_8459542_-|transglycosylase-SLT-domain-containing-protein	unknown	unknown	gnl|CDD|366659
NC_014666.1|WP_013427995.1|8445203_8446526_-|DUF427-domain-containing-protein	unknown	unknown	gnl|CDD|377265
NC_014666.1|WP_013427989.1|8437929_8439429_+|AIR-synthase	unknown	unknown	gnl|CDD|274944
NC_014666.1|WP_013427994.1|8444334_8445204_-|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223669
NC_014666.1|WP_013428005.1|8458315_8458750_+|SRPBCC-family-protein	unknown	unknown	gnl|CDD|378454
NC_014666.1|WP_157735623.1|8456605_8457775_-|DUF4407-domain-containing-protein	unknown	unknown	gnl|CDD|379583
NC_014666.1|WP_013428001.1|8453201_8454401_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|226359
NC_014666.1|WP_083819782.1|8436792_8437923_+|MSMEG_0568-family-radical-SAM-protein	unknown	unknown	gnl|CDD|274940
NC_014666.1|WP_083819783.1|8455490_8455937_-|phage-holin-family-protein	unknown	unknown	gnl|CDD|377816
NC_014666.1|WP_041262158.1|8442130_8443297_+|MSMEG_0565-family-glycosyltransferase	unknown	unknown	gnl|CDD|274943
NC_014666.1|WP_013427987.1|8436145_8436655_+|MSMEG_0572-family-nitrogen-starvation-response-protein	unknown	unknown	gnl|CDD|188559
NC_014666.1|WP_013427996.1|8446703_8447783_-|LacI-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224525
NC_014666.1|WP_013427999.1|8450329_8451376_-|sugar-ABC-transporter-permease	unknown	unknown	gnl|CDD|224096
NC_014666.1|WP_013427993.1|8443436_8444324_+|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223669
NC_014666.1|WP_041259825.1|8440502_8442107_+|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|223727
NC_014666.1|WP_041259826.1|8451545_8452808_-|extracellular-solute-binding-protein	unknown	unknown	gnl|CDD|270303
NC_014666.1|WP_013427990.1|8439534_8440440_+|carbon-nitrogen-hydrolase-family-protein	unknown	unknown	gnl|CDD|143587
NC_014666.1|WP_013428002.1|8454513_8455515_-|DUF3618-domain-containing-protein	unknown	unknown	gnl|CDD|237171
NC_014666.1|WP_157735177.1|8459723_8460734_-|MFS-transporter	unknown	unknown	gnl|CDD|224748
NC_014666.1|WP_013427998.1|8449412_8450333_-|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl|CDD|223472

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_014666.1|WP_041262164.1|8458771_8459542_-|transglycosylase-SLT-domain-containing-protein	gnl|CDD|366659	pfam01471, PG_binding_1, Putative peptidoglycan binding domain. This domain is composed of three alpha helices. This domain is found at the N or C-terminus of a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. This family is found N-terminal to the catalytic domain of matrixins. The domain is found to bind peptidoglycan experimentally.	0.000506595
NC_014666.1|WP_013427995.1|8445203_8446526_-|DUF427-domain-containing-protein	gnl|CDD|377265	pfam04248, NTP_transf_9, Domain of unknown function (DUF427). This domain contains a beta-tent fold.	2.29779e-21
NC_014666.1|WP_013427989.1|8437929_8439429_+|AIR-synthase	gnl|CDD|274944	TIGR04050, MSMEG_0567_Cter, AIR synthase-related protein, MSMEG_0567 C-terminal family. Members of this family include the C-terminal region of MSMEG_0567 from Mycobacterium smegmatis, where the N-terminal is a GNAT family N-acetyltransferase, and resemble the full length of sll0787 from Synechocystis sp. PCC 6803. The conserved cluster that contains these is found broadly (Cyanobacteria, Proteobacteria, Actinobacteria) in about 8 percent of genomes and appears to be biosynthetic. The product is unkown. [Unknown function, Enzymes of unknown specificity].	5.24993e-125
NC_014666.1|WP_013427994.1|8444334_8445204_-|alpha/beta-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	5.0014e-10
NC_014666.1|WP_013428005.1|8458315_8458750_+|SRPBCC-family-protein	gnl|CDD|378454	pfam10604, Polyketide_cyc2, Polyketide cyclase / dehydrase and lipid transport. This family contains polyketide cylcases/dehydrases which are enzymes involved in polyketide synthesis. It also includes other proteins of the START superfamily.	5.0209e-07
NC_014666.1|WP_157735623.1|8456605_8457775_-|DUF4407-domain-containing-protein	gnl|CDD|379583	pfam14362, DUF4407, Domain of unknown function (DUF4407). This family of proteins is found in bacteria. Proteins in this family are typically between 366 and 597 amino acids in length. There is a single completely conserved residue R that may be functionally important.	1.76447e-57
NC_014666.1|WP_013428001.1|8453201_8454401_+|ABC-transporter-ATP-binding-protein	gnl|CDD|226359	COG3839, MalK, ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism].	1.73306e-163
NC_014666.1|WP_083819782.1|8436792_8437923_+|MSMEG_0568-family-radical-SAM-protein	gnl|CDD|274940	TIGR04043, hypothetical_protein_WH5701_02349, radical SAM protein, MSMEG_0568 family. Members of this protein family are radical SAM proteins related to MSMEG_0568 from Mycobacterium smegmatis. Members occur within 8-gene operons in species as diverse as M. smegmatis, Rhizobium leguminosarum, Synechococcus elongatus, and Sorangium cellulosum. The function of the operon is unknown, but similarity of MSMEG_0568 to some cofactor biosynthesis radical SAM proteins suggests a similar biosynthetic function. [Unknown function, Enzymes of unknown specificity].	5.73347e-175
NC_014666.1|WP_083819783.1|8455490_8455937_-|phage-holin-family-protein	gnl|CDD|377816	pfam07332, Phage_holin_3_6, Putative Actinobacterial Holin-X, holin superfamily III. Phage_holin_3_6 is a family of small hydrophobic proteins with two or three transmembrane domains of the Hol-X family. Holin proteins are produced by double-stranded DNA bacteriophages that use an endolysin-holin strategy to achieve lysis of their hosts. The endolysins are peptidoglycan-degrading enzymes that are usually accumulated in the cytosol until access to the cell wall substrate is provided by the holin membrane lesion.	1.02698e-24
NC_014666.1|WP_041262158.1|8442130_8443297_+|MSMEG_0565-family-glycosyltransferase	gnl|CDD|274943	TIGR04047, MSMEG_0565_glyc, glycosyltransferase, MSMEG_0565 family. A conserved gene cluster found sporadically from Actinobacteria to Proteobacteria to Cyanobacteria features a radical SAM protein, an N-acetyltransferase, an oxidoreductase, and two additional proteins whose functional classes are unclear. The metabolic role of the cluster is probably biosynthetic. This glycosyltransferase, named from member MSMEG_0565 from Mycobacterium smegmatis, occurs in most but not all instances of the cluster. [Unknown function, Enzymes of unknown specificity].	3.14862e-127
NC_014666.1|WP_013427987.1|8436145_8436655_+|MSMEG_0572-family-nitrogen-starvation-response-protein	gnl|CDD|188559	TIGR04044, MSMEG_0572_fam, MSMEG_0572 family protein. This model describes a family of proteins with remote similarity to the DsrE/DsrF-like family (see pfam02635). All members are found in a context of at least seven genes that includes a radical SAM protein, suggesting biosynthesis. The system is sparsely but broadly distributed in bacteria, including Actinobacteria, Proteobacteria, and Cyanobacteria.	2.16395e-93
NC_014666.1|WP_013427996.1|8446703_8447783_-|LacI-family-transcriptional-regulator	gnl|CDD|224525	COG1609, PurR, Transcriptional regulators [Transcription].	3.55847e-112
NC_014666.1|WP_013427999.1|8450329_8451376_-|sugar-ABC-transporter-permease	gnl|CDD|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	2.06306e-76
NC_014666.1|WP_013427993.1|8443436_8444324_+|alpha/beta-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.04752e-25
NC_014666.1|WP_041259825.1|8440502_8442107_+|FAD-dependent-oxidoreductase	gnl|CDD|223727	COG0654, UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion].	2.57851e-11
NC_014666.1|WP_041259826.1|8451545_8452808_-|extracellular-solute-binding-protein	gnl|CDD|270303	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold. This family includes the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.62059e-29
NC_014666.1|WP_013427990.1|8439534_8440440_+|carbon-nitrogen-hydrolase-family-protein	gnl|CDD|143587	cd07197, nitrilase, Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes. This superfamily (also known as the C-N hydrolase superfamily) contains hydrolases that break carbon-nitrogen bonds; it includes nitrilases, cyanide dihydratases, aliphatic amidases, N-terminal amidases, beta-ureidopropionases, biotinidases, pantotheinase, N-carbamyl-D-amino acid amidohydrolases, the glutaminase domain of glutamine-dependent NAD+ synthetase, apolipoprotein N-acyltransferases, and N-carbamoylputrescine amidohydrolases, among others. These enzymes depend on a Glu-Lys-Cys catalytic triad, and work through a thiol acylenzyme intermediate. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer. These oligomers include dimers, tetramers, hexamers, octamers, tetradecamers, octadecamers, as well as variable length helical arrangements and homo-oligomeric spirals. These proteins have roles in vitamin and co-enzyme metabolism, in detoxifying small molecules, in the synthesis of signaling molecules, and in the post-translational modification of proteins. They are used industrially, as biocatalysts in the fine chemical and pharmaceutical industry, in cyanide remediation, and in the treatment of toxic effluent. This superfamily has been classified previously in the literature, based on global and structure-based sequence analysis, into thirteen different enzyme classes (referred to as 1-13). This hierarchy includes those thirteen classes and a few additional subfamilies. A putative distant relative, the plasmid-borne TraB family, has not been included in the hierarchy.	2.38312e-74
NC_014666.1|WP_013428002.1|8454513_8455515_-|DUF3618-domain-containing-protein	gnl|CDD|237171	PRK12678, PRK12678, transcription termination factor Rho; Provisional.	8.17452e-07
NC_014666.1|WP_157735177.1|8459723_8460734_-|MFS-transporter	gnl|CDD|224748	COG1835, COG1835, Predicted acyltransferases [Lipid metabolism].	0.00073013
NC_014666.1|WP_013427998.1|8449412_8450333_-|carbohydrate-ABC-transporter-permease	gnl|CDD|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	2.17115e-82

Protein sequences

>NC_014666.1|WP_013427996.1|8446703_8447783_-|LacI-family-transcriptional-regulator
MSGAVGLADPSGTSGESRGPGPAPRRAPTLEEVAELAGVSRATVSRVVNGSSRVSPEALASVTAAIAQLGYVPNRAARSLVTRRTDTLVLIVHERPDTVFSDPFFASVLRGVNRALSPTDLQLVLLQAQGEAQRDRALRYVGNGHVDGVLLISLHGDDIMPNAIAAAGVPLVMAGRLLTGRMVDYVDADNVGGARDAVGHLLATGRRRIATVAGPPDMSVGVDRLRGYTEAVRAAGGDAAAGWVVVGDFTEASGQAATERLLAEHPDLDAVFAASDLMALGALRALRAAGRRVPDDVAVVGFDDAALAAYADPPLTTVRQQVELMGQEMVQLLLARIADPDGEPRELILPTELVIRASA
>NC_014666.1|WP_013427995.1|8445203_8446526_-|DUF427-domain-containing-protein
MTNDAGPDSAQAIDHVPCRYRARAWWDGRLVAESTAAVRVTEPGRSPELYFPTADVRFELVGAAGGQAVCPVKGTARLWTLDGKSPAPRPEWEDPEHAGGDGLVDGQDAVWSFTEPAPGLDWLAELVAFDHDRVRVEIVDLVAGEDPREASVKQFPNWGDAADLIDMMDLRAVGERRQVSAIRPFAARSVVEASQILGQAIVAAMRHTGGRRVVSAQLTMYRVADTRLPLEFDLEDLSSGRTFSAVLVHVSQDGRRRASVNMLLDVTAADVFRHEDATPPVAGPYDAVPYDMSVTGRDLRVVDAAYNNDSNAPVGPPTLDAWVRFREVPADPALHAGLLAQFTGHMSLAAAMRPHAGFGQDQAHRTLSMGISAIGISLHADIRADQWMRYHHHSTFVGDGMAHAECRVYTEAGALVASFTVDATLRGLEARFHHSDKTAI
>NC_014666.1|WP_013427994.1|8444334_8445204_-|alpha/beta-hydrolase
MAFATVDGLRVAYELVGAENDGPLWVITTGGRFTRETPGVAELAAALVADGDRALVWDKPNSGASDVCFAGASEPELHADTLAGLLTHLDLGPAVLAGATVGTRVSLLTAARHPEVAAGLALWWISGGPMGLMLLGNAYYTASITTAWTRDLAAVADLPEWAGTIAANPGNRQRILDTDRAEFLETLQRWITAYAPRSDERVPGLTDAEARAVTAPALIFRGGASDPFHPRATSEAVADLLPNARLVEPPWGDREYLERQAEAATAGSAFTRWPLLAPTLRKWAQEALA
>NC_014666.1|WP_013427993.1|8443436_8444324_+|alpha/beta-hydrolase
MNEEAPPWYDHALDDRPEHFEVEVQGARITYRCWGGPPELPAIVLVHGGAAHAGWWDHIAPLIPDEYRVVALDLSGHGDSDRRDDYTLSMWAAEVIGVIDDAGISSPPIVIGHSMGGWVTITTAAEHPDRVAGIVLIDSPVTEFTPEEAAARDRTAFGPLRVYTTAADALARFRTVPQQTHTLPYVIEHIARGSIGSVEGGWTWKFDPNVFGNRTPAPEALHKVHCRVALFRAENGLVTSDIGDQMYNLLGRVAPVIEIPLAGHHVMLDQPLLLVTGIRTILADWEHSSPQERTD
>NC_014666.1|WP_041262158.1|8442130_8443297_+|MSMEG_0565-family-glycosyltransferase
MRIALLTYSTKARGGVVATLCLAEALARAGHRVDVWTLARGGDGAFFRPVDAGVTVRAVPFPDRAGESVGDRVLRSIEVLGAAFGDHHSAAGGDDATGGYDVIHAQDCISANAVPDCVRTVHHLDAFTTPELVTCHERALRRPFAHVCVSAAVAVELAAGWGIEAHVIPNGVESARFAAAAGPAAAGARARWRGRLGRYVLAVGGIEPRKGTVDLVEAMSLLRDRLPAGEPAPALVVAGGETLFDYRDYRARVLARAAELGVEPVLLGPVDHAELPSLVAAAAVFAFPSVKEGFGLAALEALAAGVPVVASDLPVLREVFAGAVSFADGPAELAAALAASLTAPDPGRRAAGDSLAARHSWDAAAAAHAELYRGLLAQRRPAVSPTGP
>NC_014666.1|WP_041259825.1|8440502_8442107_+|FAD-dependent-oxidoreductase
MTLAATERVVIVGAGAAGLLAAVFLARAGRQVLVVDRDAATPPGAGEPRPGVPQARHSHAYLARFRALLTQRAPDLLARLLAAGAREISLARTAPAEIRRSLAAAPAGPGAGVPGLPADAGELVVLGARRSLLDDVLRTAALAEPGVTIRDGCRVTGLVTAPASAGGVPWVRGVRLADGTSIAADLVVDAGGRRSPLRDLLAATGAPLPAGLEAPCGITYYSRFYARGGDRSLATELNRGHTAGASFDRYSCLVFPADNDVFSVTFGVLPEDAELRVLRHGAAFDAAVRAIGPVAPWLDVKPALAPRELDPTELDPAEPAAEPLGPVAAMAGLHNRFHPWVADGQPAVLGLLPIGDAAMITNPAHTRGTTLAALTAAWLTDVVTGTPDPAERALRLDATMRAEALPWYHDSLAQDAARLSRWRPSTAVAPAPRSPDEAGTYEAGAGPQAVTNGEAFLASARDPVVWHAFTRLQNLLALPSDVLADPGIVARVRAVQASGWRPVPAPGPSHADLVATAGAALARAGGSQAPDGSP
>NC_014666.1|WP_013427990.1|8439534_8440440_+|carbon-nitrogen-hydrolase-family-protein
MSVMTIGVVSDSFGRDLATCFEQVARYIEKARAQGVQLLALPEAALGGYLPELGSTDDPGVGEPAPLLAADGPQIARLVELAGDMIVCIGYSERAGARRYNSAVCVGGGEVLGRYRKVHLPLSEGASYDAGTGFHAFDTPLGRIGMMICYDKVFPEAARGLALDGAEIIVCLSAWPMARTKPADTPAGDRWRFRFDTFDVARALENQVVFVSANQVGRFGTLTFVGNSKILHADGTELAATGEEPGMAVARLDVDEALFVARRGLNHLRARRPDAYDTQCLLAGEPLLRQPPRLIPPARTG
>NC_014666.1|WP_013427989.1|8437929_8439429_+|AIR-synthase
MVGALLAGDPVAAGPVAPAGLSGRPGPVDTLAVWGDPGTLRRRPPYRIERAHDAATIAAYHRLRRAVFVDEQGLFADGPAGDLDETDEDPRTTVLVARAVGGPQEGQVIGGVRLGPTAAWPGPDIGWWQGGRLAVRAAARQRYAGVGGALVRAACAHAEAAGALRFDATVQQSRERFFGRLGWMTVGPTTVNGAPHALMRWPIHRVAMLAAITKAPLGALLGGLRPGGTGFVGDDGAPVPGTDMVAACDAILPAMVDRDPFWAGWCGVLVNLNDLAAMGAQPLGLLDAVAGPTESRVSRVLAGLRAASDAFAVPILGGHSQLGVASSLAVTAVGRAEEPIRAGAGLPGHVITVTADLAGGWRPGYTGRQWDSTSTRRTAELRGMLSLTVRHRPVAAKDVSMAGIVGTLGMLAESSGCSAEIDVARVPRPAGVPAGDWLTCFPGFAMVTADVPERPMPAMSQAVSACCGRLVPGSGVSLLWPDGLRTPVLGGHVTGMGPA
>NC_014666.1|WP_083819782.1|8436792_8437923_+|MSMEG_0568-family-radical-SAM-protein
MTDKASAALTASADLDTGSRLAAARPASLETRVGLAVHGVRLTAPVSRRAGAGPSDDGHVVLGGRGVALPIVATSRYEVSGDRLLFEGTDLGIPVEPVRRPRFYDLTTADGIRYEQLARLHGADVLATTVLQTCVRYQEADRCRFCAIEESLRAGATTARKTPAQLAEVAEAAVRLDGVRQLVMTTGSTAAPDRGARLLAEAVRAVLAAVPGLPIQVQCEPPADLGAIRELREAGASAIGIHVESLDDAVRARWMPGKATVPLAAYEAAWTEAVRVFGRNRVSTYLLIGLGEDPDELVAGAERLIGLGVYPFVVPFRPIAGTLAARDGARAPDQAVVADVTRRVAAALRAAGMRGADQTAGCAACGACSALPEAGG
>NC_014666.1|WP_013427987.1|8436145_8436655_+|MSMEG_0572-family-nitrogen-starvation-response-protein
MELTELEQQSIAEVPHPSLPPGSNLYGSTKIFPDYQAENGESYLTLIHGIAHESSVSFVAILQATRALRKGFESVIYFYGPGAMNAMATRGFPHTGDSAFAGEHNINNQLETFIKEGGKVYVCRFGLSLHGLREEDLIEGVIPAHPLDIQDCVIHYARKGAVINSTYMF
>NC_014666.1|WP_013427998.1|8449412_8450333_-|carbohydrate-ABC-transporter-permease
MSVATQEPVGASVPPTGPPGPAARGARRRRDIDPSARRPGLLRYPFLIVILLISIFPVYWTFLVPSRTNADVAKVPPPLTPGPHFFENLRRVFDTVGFGKALTNSLLVASSITLCTLLFCSLAGFAFAKLRFRGRNALLLIVIGTMMVPVQLGVIPLYIEMHKFGWTNHLISVIVPTAVTAFGVVFMRQYTEQAIPDELLEAGRMDGCSTLGLYWHVVLPGLRPAMAVLGLLTFMQAWNDFMWPLIALSPQNPTVQVALSSLSAGYYRDNTLVLAGTAIGTLPVIVVFIVFGRQIISGIMEGAVKG
>NC_014666.1|WP_013427999.1|8450329_8451376_-|sugar-ABC-transporter-permease
MTTLVTPASTADAAPPRRRPSAVRSGIRRVTGVTAPYGFVAPFFLLFAVFGLFPMLYTFWVSLHDRSMLSSHSGKMIGLRNYSELMADPYFWHAVRNTFLLMFMCTIPQLVLALVLAHTLNSRIRGRTLFRMGVLLPNVTSIVAVTLVFGQLFSFHYGLFNWALHTVGLPRINWEAGTWSSKIAISSMVIWRWTGYNALIYLAAMQAIPKEQFEAAAIDGAGTWRQLWHVTLPALRPTIAFTGLVSIIGQIQLFTEPLLFETTPGSVTGGTSRQFQTLALFMYEEGFHLYHFGYASAVAWLMFLLTVLLAGGAYLITRGGALVGGARQAGRARRVRRLRADDTPGGTR
>NC_014666.1|WP_041259826.1|8451545_8452808_-|extracellular-solute-binding-protein
MTGAFLVTALVATACGGSSDNGAGGGNKSTTLVVNDFSTFGYKDAGLYAAFEASHPGVKIVENISEYNTHHNNLVKHLAAGSGAGDVEAVDEGFMAQFKATPDLFANLNDYGLASRKADYGSYKWTMGESTDGKSLFGLGTDVGGLAMCYNTQLFQKAGLPTDPAAVAALWPTWDAYFQTGQKFKAANTGATWFDTGTNVYNAQVFQLKESYYKPGTDDVEVGTNPGVKAAFDSTAAAIQGGLSGGLVSFSDDWTKAIANGAFATLTCPAWMMANIQQAKPGEGIWNVAAVPGKGGNWGGSWLTVPAQSKNKKLAAELVDFLTEPENQVKVFKSVGNVPSTVGGVNDPTVQSFTNPYFLNAPTGKIFGESALSLTPQYQGPKHGAIRAAIEAQIQNMEQKHTDPAAAWTAAVSDAERAAR
>NC_014666.1|WP_013428001.1|8453201_8454401_+|ABC-transporter-ATP-binding-protein
MSTIELRDVSLTYGVGPVLDNISLSVEDGEFLVLVGPSGSGKTTALRIVAGLLSPTSGQVFVGGEDVTRVPPAERDLAMVFQSYALYPHMTVRNNMAFGLRLAGVSRKERDERVERAAKILGLTELLDRRPKALSGGQRQRVAMGRAIVREPRAFLMDEPLSNLDAKLRTQVRAQIGRIQRNLGITTLYVTHDQIEAMTMADRIAVLHEGRLQQLGTPDELFSQPANVFVAAFIGSPATNLIPGTLTTADGQTALRVGGQTLVLPAELAAAVTAASTPEVLVGVRPHDVETRPPDAAALTLEVDVDLVERLGTETLVHGEMVTGSVSGAAAQAAHALTAADDGLPTDPDRHRFTAALDARTEVSAGSRLPFYVAAARLHLFDAETGVTLRADRKSLAAV
>NC_014666.1|WP_013428002.1|8454513_8455515_-|DUF3618-domain-containing-protein
MGARPEEIRSEIEETRDRITAEIDELTARYSPGRVASRKANGARDAATSMRAKVGSGAAGMKQRLALRSSSHHEHSSTCGHLGEGQTGTGQALDVGVSQAAAERRGEAQRRERGGRLRRHRQHEDQPPAPYPADVRRVDSSYDPASGPGSADFRPPRRQAEAGVPSHDPSTYRADDHVTYARVRKHLSSFPRGHHGHGHRQADEQRSDEQRTDQQRSSVAAGGSQQAGGPRPGDRSGRGRKRDLGLAGASIVIGALGARTVRHPGRREKDLLEAANRKRPYASSGPADSEADGGSRAGAMSGLTSAAARAALKRKPASKKATAAKKEHSETAS
>NC_014666.1|WP_083819783.1|8455490_8455937_-|phage-holin-family-protein
MTADRTATAGPGTLDRQGAGGRKGRRGAGALVSEVASDMSMLVRQEIDLAKAEVRQSAVRAGKGAGMFGGAAGAGIFAVLFLLLAAMFGLAEVMALGWAALIVAALLIAAAAVFALMGRANVKKAHAKPEQTVETLKEDMQWAHGLRK
>NC_014666.1|WP_157735623.1|8456605_8457775_-|DUF4407-domain-containing-protein
MLLTASLAAYAGASVAAFGFGTSTLAALPYGLFYAAFIFFIDRSVLLTIRPLRLAGKGDKERIRPRRLLPTGVIRILIAIVGAILVGESLLLRFFDASIEPRVAELRQQELAGVMSSWDAGQRTTEAGLVAALDDQRAQLASAENLVTAKTGEVDCQLTGGDGCLGGRGPIYQVKLGELRAAAAQIPGLRAARDAAQNRLDSFRVTRDQRRAQYADTEWRSIGNANDLLMREKGFWRLTAADNSVKVWRILISLLILGIDLAPLLFKRNLDRTAYARLERGALWEGETNEEVDAFQLDRNARARRGKAGEVAERMAARYEEYAVAREELRLAASLDEDEGAAALRRDERRLGNDRQAADLRRAYRLPAPLATPPPRGAATDGTGSHTPG
>NC_014666.1|WP_013428005.1|8458315_8458750_+|SRPBCC-family-protein
MGQINVVTQRSLPAPPDRVLDLAADYAGTRAQLWPENITDYQVLAGGKGPGTRISYRLHATKKRIRDVAAEVSAPDAQSLVEADQNSTLRTVWRVRPEGDGSHVTVMTTWTGAGGVGGFFERIFAPIGVRKLWTAVLDNLSARL
>NC_014666.1|WP_041262164.1|8458771_8459542_-|transglycosylase-SLT-domain-containing-protein
MTTPVREGRGGWPSDGRGGTISADGTGFGPYYGVGAGQRAPDGSAADDIAAVKGGVKAIQRALNWHQATSKPIPTDGVFSQTTRSALIAFQQQKQPTINRDMYIPANERSPLGLVHKETSYALFMPIADRYALKYTVPRGLLRGITTIESNWDPGAIGYYTNSDFGLCQWNTTLPDITKDNALDPFWALDSTAHMMRTRIDATDWGKNWIYVIAAHNVPTWALQWAQGKLVPGSADDQPKLDRMTGYVTNVLARTW
>NC_014666.1|WP_157735177.1|8459723_8460734_-|MFS-transporter
MTATGDTGYNLARGTWRIPRSRGAMAGLLLMVLGAWGALIPFIGPAFHFGFGGSQTWSWTAARFWLEVLPGIACFVGGLMLTFSANRGATMLGAWLAMAAGAWFIIGPTVAGPLHLGDLGIPMGGTARVTWTWLLFFYGLGAVILSVASIAHGRLSVRSLRDVEHATMHARSKQLARHGGGLFGGVGHGRGRGDREREPARHNSGRDDRMDRAERDSRDRDLQDRDSRDHAPYPTDTAHADRAGGPTALPVDSRSRRDVQASEQGVRDESAARRGETTTTVYPSETESVRSSTTETQRGRHEAGHEGFSEKIGHFENAIGRTLAKHGIGGNKQDRR

Crispr_ID: NC_014666_18

• CRISPR_ID: NC_014666_18
• CRISPR_location: 8704683-8704824
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_014666_18

Consensus_repeat	Method
CAGGCCTTCCCGCCCCTTCGGACCTCCTGACCAGGTCCCCCCCAATGCAGG	CRISPRCasFinder

spacers of NC_014666_18

>18.1|8704734|40|NC_014666|CRISPRCasFinder
GGTCCCCGCGCGGCGCCGAAGGCGACGTGTGGGGCAAGCA

CRISPR arrays and Neighbor proteins around NC_014666_18

CRISPR arrays

The CRISPR arrays of NC_014666_18

>merge|NC_014666|18|8704683-8704824|CRISPRCasFinder
CAGGCCTTCCCGCCCCTTCGGACCTCCTGACCAGGTCCCCCCCAATGCAGGGGTCCCCGCGCGGCGCCGAAGGCGACGTGTGGGGCAAGCACAGGCCTTCCCGCCCCTCCGGACCTCCTGACCAGGTCCCCCCCAATGCAGG

>NC_014666|18|15|8704683-8704824|CRISPRCasFinder
CAGGCCTTCCCGCCCCTTCGGACCTCCTGACCAGGTCCCCCCCAATGCAGG	GGTCCCCGCGCGGCGCCGAAGGCGACGTGTGGGGCAAGCA
CAGGCCTTCCCGCCCCTCCGGACCTCCTGACCAGGTCCCCCCCAATGCAGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_014666.1|WP_013428212.1|8720173_8722588_+|protein-kinase	unknown	unknown	gnl|CDD|270916
NC_014666.1|WP_013428205.1|8707736_8708366_+|hypothetical-protein	unknown	unknown	gnl|CDD|237030
NC_014666.1|WP_157735222.1|8690542_8691454_+|metal-ABC-transporter-permease	unknown	unknown	gnl|CDD|224033
NC_014666.1|WP_013428201.1|8701664_8703452_+|2-oxo-acid-dehydrogenase-subunit-E2	unknown	unknown	gnl|CDD|365941
NC_014666.1|WP_013428204.1|8705373_8707242_-|acyl-CoA-dehydrogenase	unknown	unknown	gnl|CDD|173842
NC_014666.1|WP_157735224.1|8696561_8697926_-|CapA-family-protein	unknown	unknown	gnl|CDD|378215
NC_014666.1|WP_041262210.1|8697988_8698891_-|LLM-class-F420-dependent-oxidoreductase	unknown	unknown	gnl|CDD|274681
NC_014666.1|WP_041262213.1|8712205_8712445_-|hypothetical-protein	unknown	unknown	unknown
NC_014666.1|WP_013428210.1|8715486_8717199_-|glucose-6-phosphate-isomerase	unknown	unknown	gnl|CDD|234679
NC_014666.1|WP_083819694.1|8708544_8711856_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|226415
NC_014666.1|WP_013428194.1|8692123_8692930_+|hypothetical-protein	unknown	unknown	gnl|CDD|237030
NC_014666.1|WP_157735226.1|8704920_8705217_-|hypothetical-protein	unknown	unknown	unknown
NC_014666.1|WP_083819693.1|8699123_8700551_+|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha	unknown	unknown	gnl|CDD|213783
NC_014666.1|WP_013428213.1|8722686_8724288_+|FAD-binding-oxidoreductase	unknown	unknown	gnl|CDD|223354
NC_014666.1|WP_013428200.1|8700538_8701582_+|alpha-ketoacid-dehydrogenase-subunit-beta	unknown	unknown	gnl|CDD|223101
NC_014666.1|WP_157735634.1|8689520_8690546_+|metal-ABC-transporter-permease	unknown	unknown	gnl|CDD|224033
NC_014666.1|WP_041259848.1|8714477_8714798_+|hypothetical-protein	unknown	unknown	unknown
NC_014666.1|WP_013428193.1|8691414_8691909_-|transcriptional-repressor	unknown	unknown	gnl|CDD|133478
NC_014666.1|WP_041259849.1|8717573_8720138_+|protein-kinase	unknown	unknown	gnl|CDD|271323
NC_014666.1|WP_013428195.1|8693205_8694420_+|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl|CDD|181738

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_014666.1|WP_013428212.1|8720173_8722588_+|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	7.30096e-91
NC_014666.1|WP_013428205.1|8707736_8708366_+|hypothetical-protein	gnl|CDD|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	0.00019616
NC_014666.1|WP_157735222.1|8690542_8691454_+|metal-ABC-transporter-permease	gnl|CDD|224033	COG1108, ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism].	3.8767e-46
NC_014666.1|WP_013428201.1|8701664_8703452_+|2-oxo-acid-dehydrogenase-subunit-E2	gnl|CDD|365941	pfam00198, 2-oxoacid_dh, 2-oxoacid dehydrogenases acyltransferase (catalytic domain). These proteins contain one to three copies of a lipoyl binding domain followed by the catalytic domain.	1.56422e-87
NC_014666.1|WP_041262210.1|8697988_8698891_-|LLM-class-F420-dependent-oxidoreductase	gnl|CDD|274681	TIGR03620, F420_MSMEG_4141, probable F420-dependent oxidoreductase, MSMEG_4141 family. Members of this protein family, related to F420-dependent oxidoreductases within the larger family of a bacterial luciferase (an FMN-dependent enzyme), occurs only within the small subset of species that synthesize F420. Most such proteins are from members of the Actinobacteria, but at least one species, Sphingomonas wittichii, belongs to the Alphaproteobacteria. [Unknown function, Enzymes of unknown specificity].	1.17151e-118
NC_014666.1|WP_157735224.1|8696561_8697926_-|CapA-family-protein	gnl|CDD|378215	pfam09587, PGA_cap, Bacterial capsule synthesis protein PGA_cap. This protein is a putative poly-gamma-glutamate capsule biosynthesis protein found in bacteria. Poly-gamma-glutamate is a natural polymer that may be involved in virulence and may help bacteria survive in high salt concentrations. It is a surface-associated protein.	1.29554e-77
NC_014666.1|WP_013428204.1|8705373_8707242_-|acyl-CoA-dehydrogenase	gnl|CDD|173842	cd01153, ACAD_fadE5, Putative acyl-CoA dehydrogenases similar to fadE5. Putative acyl-CoA dehydrogenase (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	5.60395e-175
NC_014666.1|WP_013428210.1|8715486_8717199_-|glucose-6-phosphate-isomerase	gnl|CDD|234679	PRK00179, pgi, glucose-6-phosphate isomerase; Reviewed.	0
NC_014666.1|WP_083819694.1|8708544_8711856_+|AAA-family-ATPase	gnl|CDD|226415	COG3899, COG3899, Predicted ATPase [General function prediction only].	4.41754e-59
NC_014666.1|WP_013428194.1|8692123_8692930_+|hypothetical-protein	gnl|CDD|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	7.28113e-09
NC_014666.1|WP_083819693.1|8699123_8700551_+|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha	gnl|CDD|213783	TIGR03181, PDH_E1_alph_x, pyruvate dehydrogenase E1 component, alpha subunit. Members of this protein family are the alpha subunit of the E1 component of pyruvate dehydrogenase (PDH). This model represents one branch of a larger family that E1-alpha proteins from 2-oxoisovalerate dehydrogenase, acetoin dehydrogenase, another PDH clade, etc. [Energy metabolism, Pyruvate dehydrogenase].	3.75676e-161
NC_014666.1|WP_013428200.1|8700538_8701582_+|alpha-ketoacid-dehydrogenase-subunit-beta	gnl|CDD|223101	COG0022, AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion].	1.1382e-150
NC_014666.1|WP_157735634.1|8689520_8690546_+|metal-ABC-transporter-permease	gnl|CDD|224033	COG1108, ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism].	5.27623e-56
NC_014666.1|WP_013428213.1|8722686_8724288_+|FAD-binding-oxidoreductase	gnl|CDD|223354	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion].	2.27571e-33
NC_014666.1|WP_013428193.1|8691414_8691909_-|transcriptional-repressor	gnl|CDD|133478	cd07153, Fur_like, Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators. Ferric uptake regulator (Fur) and related metalloregulatory proteins are iron-dependent, DNA-binding repressors and activators mainly involved in iron metabolism. A general model for Fur repression under iron-rich conditions is that activated Fur (a dimer having one Fe2+ coordinated per monomer) binds to specific DNA sequences (Fur boxes) in the promoter region of iron-responsive genes, hindering access of RNA polymerase, and repressing transcription. Positive regulation by Fur can be direct or indirect, as in the Fur repression of an anti-sense regulatory small RNA. Some members sense metal ions other than Fe2+. For example, the zinc uptake regulator (Zur) responds to Zn2+, the manganese uptake regulator (Mur) responds to Mn2+, and the nickel uptake regulator (Nur) responds to Ni2+. Other members sense signals other than metal ions. For example, PerR, a metal-dependent sensor of hydrogen peroxide. PerR regulates DNA-binding activity through metal-based protein oxidation, and co-ordinates Mn2+ or Fe2+ at its regulatory site. Fur family proteins contain an N-terminal winged-helix DNA-binding domain followed by a dimerization domain; this CD spans both those domains.	2.11716e-37
NC_014666.1|WP_041259849.1|8717573_8720138_+|protein-kinase	gnl|CDD|271323	cd14953, NHL_like_1, Uncharacterized NHL-repeat domain in bacterial proteins. This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.	5.69928e-96
NC_014666.1|WP_013428195.1|8693205_8694420_+|pyridoxal-phosphate-dependent-aminotransferase	gnl|CDD|181738	PRK09265, PRK09265, aminotransferase AlaT; Validated.	0

Protein sequences

>NC_014666.1|WP_013428201.1|8701664_8703452_+|2-oxo-acid-dehydrogenase-subunit-E2
MARREFRLPDLGEGLAEAEIVQWLVTAGDRVTVNQPLVEVETAKAVVELPSPFAGLLVATHGAAGDTISVGTVLVTVEDDETAEPAAAAGAPPAAGARTGGAPEPSPGAAAAVPAPAGAAGGGGREPMLVGYGPRAAAVGGPAGLSRTRRRHHRVAAANGAQAAITAPAGSRAAATPPGDPHEGGPTLAKPPVRRLARDLGVDLGGLVGTGPAGTISRHDVEAAAGVLGHPGPPADARFTPSAPARPAGPSAAPAVPPAGAPGWGPRTVPPAGTPRPDSAARPDVNARPTGVTRPGGVTRPDGAARPDGLGWPDGTAQAGAGARLDGTALAAGPAAPQPGGQPAEPVGWVPAGATFDEVSRTWRIRVSGVRRATARAMVSSAFTAPHVTEFVSVDLTETLAVRDRIATLPEFAGLKVTPLLFVARALVAAVRRHPMINAGWVESGVGDPEIVVSSAVNLGIAVASPRGLLVPNVPDADRLDLAGLAQALHDLTTRTRSGRARPADLSGGTITITNIGVFGVDIGTPILNPGEAAILAIGAIRPAPWVHEGQLAVRTVGQLALSFDHRLVDGELGSAVLADIAAMLTDPTLLLAWS
>NC_014666.1|WP_013428200.1|8700538_8701582_+|alpha-ketoacid-dehydrogenase-subunit-beta
MPTLTLAGALNNGLRAAMETDPKVVVMGEDVGRLGGVFRVTDGLRARFGEDRVIDTPLAESAIIGTAIGLAMRGFRPVCEIQFDGFVYPAFDQIVSNLAKLHYRSAGRTRMPVTIRIPVGGGIGAVEHHSESPEAYFCHTAGLKVVTCSNPADAQVMIQQAVAADDPVVFLEPKRRYWEKDEVDPVILGALGIADDGAPAGSVMVPAARVPAPLFSSRVVRPGSDATLVGYGPMVRTCLDAALITEAEDGRSLEVIDLRTLSPLDLDPVIESVRRTGRLVVVHEAPSNVSLSAEVAARVTEQAFYSLEAPVLRVTGFDTPYPPSRLEESYLPDVDRILDAVDRTFTY
>NC_014666.1|WP_083819693.1|8699123_8700551_+|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha
MTELMQLLTPSGQRVATASGREIEAHVADVGVADLLDLYADMVVVRRLDEEATALQRQGELGLWAPLRGQEAAQVGSARALAPDDMAFPSYREHGVAYCRGVDPVAVLGLFRGVSHGGWDPAEHGFALYAIVVGAQTLHATGYAMGVTRDGGQCATITYFGDGASSQGDVNEAFGWAAVFSAPVVFFCQNNQYAISEPTAYQSRVPISQRAVGYGFPGVRVDGNDVLATLAVTRWALERARAGDGPTLVEAVTYRMGAHTTADDPTRYRDAAEVAAWAQRDPIARVRAHLVGEDALDPTGEAAIAARADEIAADLRRRCLALPDPAPLTLFDHVTVEESRQLAAERADLAGLLAAGPDDGGSGDGGSEDGGLYLGDPYPDDPRRGDEYQHAPYPDDPRQGGATNPRPTGSASPRPPAASSRVEGAPAAAAGVEADTAAAPQPAAQAPAANAATRLNGGRPVAPPQFPGPEASCPH
>NC_014666.1|WP_041262210.1|8697988_8698891_-|LLM-class-F420-dependent-oxidoreductase
MVDGAALGQVGVWSGQFDFSPAGVVREAVAELDELGYPTVWTGEVKGREVLVTAGMMLAATARITVATGIAQILARNPLTMAAGQLALAEAFPGRFVLGLGVSHAELMQIRGVPYTKPLGQMSAYLAEMDRMATEQYRAVPPLVEPPRVLAALGPKMLELARDRADGAHTYFVPPEHTAAARKTLGSGKLLVPEQAFVLDTDTERARELARRHTGSYLRLPNYTNNLRRYGYTDDDFANAGSDRLVDMIVPHGGPEVLAARIAEHLDAGADQVAIQVLDYDRRGLPRRQWRELAPALLAL
>NC_014666.1|WP_157735224.1|8696561_8697926_-|CapA-family-protein
MASGLPVSAYRVLWLGSRNGQGGAAVPSRGDQGRPDASGTGVRAPEHRNGWRGGPVRAGAALTAVGLALAGCGLLGGSSSDGTAGGADAVASTGVADQASATTAANVPPGGTRRAPTGQPVTLQFAGDVHFAGSAAAALNGFGPIVPELSAADLTMVNLETAITDGGDPADKEFTFRAPARAFTALRGSGVDVVTMANNHAMDYGTTGLRDTLSAAQAANFPVVGIGADDTAAFRPYKVTIKGQRIAIIGATRVLDDNLAAAWTSGPGKPGLASAKDMTELLAAVRAVRADADTVVVDLHWGVETHSCPGTDQTGIVPELVAAGADIVVGSHAHVLEGGGWHPSGAFVDYGLGNFVFYSSGMAANTQSGILRLTVQGRAVTQAQWLPARISGGLPRPATGVDAQQIVGTVGSLQQCAGLNANPPTWGAIPASSGSTAQPAAAPTSPPAAAPTHG
>NC_014666.1|WP_013428195.1|8693205_8694420_+|pyridoxal-phosphate-dependent-aminotransferase
MEFTQSDKLAGVCYDVRGPILDEATRMETAGQRILKLNIGNPAPFGFSTPPEVLASVMENLASAQGYSDSKGLPAARAAVVDYHRRKGIAGIGPDDVYLGNGVSELIMMSLQALLNNGDEVLLPAPDYPLWTAVVSLCGGRPVHYLCDESADWAPDIADVAAKITPRTRALVLINPNNPTGAVYDRATVEALVELARQHNLMLFSDEIYDRVLFDDAEHVSTAALAPDVVCVTFNGLSKSYLLAGFRAGWMVVSGPRQHASSYIEGLNILANMRLCANVPGQYAVVAALANDEGAGSLVLPGGRLREQRDTVVKLLADIPGVSCVPPRGALYAFPRLDPEVYPIKDDERFVLDLLRAEKILLVQGTGFNWPRPDHVRIVTLPTVDDLTAAIGRIDHFLSTYTQR
>NC_014666.1|WP_013428194.1|8692123_8692930_+|hypothetical-protein
MAVPRLSLRAKADGEPSELWKPFALAGAILIAVAGVLTTCAGPKPADSTANSGGSSFAASTVSSDALTRWYVGTQAIRQLIALDVAAVRTDLAGQNGSALQPVCSSLADAVTEARALTPGPDSAAQDLFDGGLDGYGNGVAACGNLFDGTAAPKSTIEQRIRDGLTKGDAQWSALATRVGQPMATFSPPAPSAGATPAPPPATPSATPRPTASATTVRRTAAPTTPAGATTPPPPPASSPPPSVTAVPSTEAPPTPTPSATKTGILGA
>NC_014666.1|WP_013428193.1|8691414_8691909_-|transcriptional-repressor
MDGVSTVNRSQASDEATGPGPAAAVGRATAGRGAATRSTRQGDAVSAALAATNAFTSAQELHARLRADGQPVGLTTVYRHLQVLADRGEVDVLRLDDGETVYRRCATDTHHHHLVCRICGHTVEVAGREIEHWTEQVAAAEGFTDVAHTVEIYGRCASCAAAGA
>NC_014666.1|WP_157735222.1|8690542_8691454_+|metal-ABC-transporter-permease
MMLWQTLGDGYTRRALAEAVLVGLLCGAVGVHIVLRRLSFLTVALTHATFPGVVVAALLGVPLVLGAGVFGLVIVGVVALVAGARGGSAGALPSAAPTGRGGRDVSSVTGVVLSGGFALGVALMSAQDGFTKDLTAFLVGSILTVDESDLVVSAVTAVLVLAVLAALRKELLLGAFDPTALAAGGYPARRLDLVVLVALELAVVTTVPAVGTIMAIALVVGPAATARLWCVRTGPMTALSMVLGVFAGVVGLAVSAQWNIAAGGAIVLTVTALFAGSLLLAPWLRAEARTAQAPAAAQLAQRP
>NC_014666.1|WP_157735634.1|8689520_8690546_+|metal-ABC-transporter-permease
MIDLLTAPFERPYLTRALIELLLLGGVAAVVGVFVLLRRLAFLTDALTHTVFPGVVIGFLLSGQPGIFPGALVVGCLSAALFTVLAATRRVEEDATLAILLTGFFAIGVVLVSRRSSYTSDLTAFLFGRVLTVRSQDIETTAVVAAVVLLLLVALRKELLLVAFDAQAAQAAGYRVVVLDLALNLSIALVVVAAVRAVGTVLVIALIVVPAAAARLLSDRILAITAIAAAFGMAGGWAGLLISYKISVDHGVRLATGATVVLVLVAGYLLALVVASIRARARIGRPRASADVPAGTVRARPGRLSPADPAHLPIEDWRHPATDQAARAAALTVDPEAGRAP
>NC_014666.1|WP_157735226.1|8704920_8705217_-|hypothetical-protein
MGIMVSLVFFAVGAIFTFAIRAEPSGISLVAVGVIIMLVSVAGFAASFYRDLWRRRIFEESIEQGATPPLSLDDDIVVEPTAPIVAPVHDYPNLTEPL
>NC_014666.1|WP_013428204.1|8705373_8707242_-|acyl-CoA-dehydrogenase
MGHYRSNLRDIEFNLFEVFKVDQILGTGPFAEMDRETAHEVLVELERLATGPLGESFADADRNPPQFDAATGTVRLPESFKKSYRSLEEGEWWRLFVPAHLGGLGAPPTVAWAASELILGSNPAVFMYMAGPTFAGILDQLGTESQKKFAAQAVERQWGATMVLTEPDAGSDVGAGRTRAVQQPDGTWHIEGVKRFITSGDWDIPENIFHMVLARPEGHGPGTKGLSMFIVPKFMPDPETGAPGARNGVYVTNVEHKMGLKVSATTELRFGEKTPAVGWLVGDVHDGIAQMFQVIEHARMMVGTKAIATLSTGYLNALEFARTRVQGADLAATDKGAPRVTIIHHPDVRRMLMAQKAYAEGMRALVLYTASFQDTVAAAESEGGVPGSRAALSGADGSAAERAARMNDLLLPIVKGVGSERSYELLASSLQIFGGSGYLQDYPVEQYIRDAKIDTLYEGTTSIQGQDLFFRKIVRDQGQALTALLIDIQAFAKGDAGNGTLAKERDQLAAALEDVQSMVGALVGFLTSAAENRDEVYKVGLNTTRLLMSLGDLVIGWLLLRGAEVAITAVEAGPSARDAAFYQGKIAAAKWFAANVLPELHTRRTMLEAADLDLMTLPEEAF
>NC_014666.1|WP_013428205.1|8707736_8708366_+|hypothetical-protein
MAGWARVRQAVVASVMPAMVAAALFGTLVGCGHDRSQSTATSAVNTAPGGPDASAGSVGPNSATPAPAPSTEAEPSPGTTGASPGETGAAADGTASGGPAGADSSEQAASPDVAASPVFVGEPCVPSQDSAPGAAINGLTLFCVPVAGPTGSAGLGAWSDSPPKPQPSGPASGTACSSSDVGQVQRDPSGRPIACLRESNGDLRWADIS
>NC_014666.1|WP_083819694.1|8708544_8711856_+|AAA-family-ATPase
MWDGSPRSRPMPKSPAVGRPVRPTIRHMVRCPVCARQNQDDSRFCSACGNALPTAVSGTRKTVTVLFVDITDSTRLAENIDSEPLQQVMARFFDLAREAIYAHGGTVEKFIGDAVFAVFGIPVLHEDDSLRAVRTALEIRARLRELNLDLHRGWGIGLRVRIGINTGEVTVAGGGVTGDAVNVASRLEVAAAPDEILIGDVTYRLIRHSVTVDSVPPMVVQGKRDPVRAHRLLGLVDPTAGPGSRTPSLSLAAPVIGRNRERRRIQDAFEAVVEERICHLFTVLGPAGIGKSRMVKEFCDGVASRATVLSGRCLSYGEGIAYWPLMEMVRQATGMSADSPAPEGKRRLRELLDELGVAGAPEVVAALAPLVGLGGAEVGTQESFWAVRTFFHALAERRPLVLCFDDVHWAEPTLLDLIEHITDWSRDAPILLLSLTRPELLEERRQWGGGKLNATSMLLQPLTEARCQRLIRSLMGSDDLEPGLVARITSSAAGNPLFVEQMVAALVDDGLLRRDGDRWTATGSLRNVKVPPTISALLAARLDRLDTAERQVLERAAVVGARFYLDAVVDLSEPEERPQVAAHCLALVRKELVHPDRSDLPGVEAFRFLHVLLRDCAYQATSKRQRADLHERFARWLQARMVGGPGEHDELVGYHLEQAYRYRVELGQRDAATVELGRQAASCLIEAADRVRQGDEMGAAQLLKRAIVLLPELEPLRLRAEIDLGWALYSFGRLSDADRILRQVTERSRRAGEDGLRAHARLAHLRVLFSTEPDGLVATTLDEAGEALSDFVRDGDEVGAALACRSQAAAYTAAGQFGAAEKAMEMAVGHAEDSGVPRAAQSLRRELIGLLSWTPRSVGEAIGLATSALDAAGDDRGQRRALLAQLAVLTAMSGDLEAARTHLKDAEEIVWEVRGPRFDPLHSGFVVARVAVLADDLVTAERELRRSCRHLSRMGERAYLATRAAALADVMLALGRLDDAGKYVTRCRDAAASDQLPAQAGWCGVHARLLAIRGRDDEALRFAETAVDLSGQTDDLDGQAVALLARAEVLHRADRKDEAAVSLASAIERYHRRGNVTAAALANRAFESLEGPDTTVVMLSPPR
>NC_014666.1|WP_041262213.1|8712205_8712445_-|hypothetical-protein
MVREQVDYALAEIALAKAAFRRACEDTGRPGWPFRDTEVDLMRRPAVAHALFCELAGVERLRVWAQELYWLQEQNRGFA
>NC_014666.1|WP_041259848.1|8714477_8714798_+|hypothetical-protein
MIAFPLVMMLVMLLMNSVERWLTSPGRAPLRLVPSGAAGTPPDDGRGDGEAAEATAITLEPAAAAEVPLIAAMGTSDGGSRAAELHPALALVNATRSAGRVSAADA
>NC_014666.1|WP_013428210.1|8715486_8717199_-|glucose-6-phosphate-isomerase
MSSSVPNSESSPLGGEPVVITQTAEWAALRAHHAELAGTGLRALFAAEPGRAEKLSAQTDGLFLDYSKNLVTAETMRLLVALAERAGLAGRVEAMFAGEKINTTERRAVLHTALRAPEGETVLVDGENVVPQVHAVLAKMYAFADRVRSGVWTGATGKHIRTVVNIGIGGSDLGPAMAAEALRTFADRSIQTRFVSNVDGSDIWEATHDLDPAETLFVISSKTFTTLETIANAKTARAWLVAELGVDAVPHHFVAVSTNAEKVAEFGIDTANMFEFWDWVGGRYSMDSAIGLSLAVAIGPENFAELLSGFHAMDVHFRTAPLDRNLPVLLGLIGLWYRDFFGLQTHAVLPYSHYLSRFAAYLQQLDMESNGKSVDRAGHPVTAATGPVVWGTPGTNGQHAYYQLLHQGTTVIPADFIGFVAPPHAQVGGSGAADQHLLLMANFFAQTEALAFGKTAAEVAAEGVAPELVPHKVFTGDRPTNTLLAPKLTPFTLGQLIALYEHKVFTQGTIWGINSFDQWGVELGKVLAGRIIPELAGEEEPALAHDGSTNALIHRFRAGFAETLPAPAGA
>NC_014666.1|WP_041259849.1|8717573_8720138_+|protein-kinase
MLIDRSLVEAALPGYQVEGDLGKGGYGLVLAGQHRLIGRKVAIKILLDTSDDPELRARFLAEARVLAELDHPHIVRVHDYVEHEGTCLLVMELLPGGTLKQRIQAGKINQETVCAVGIAAAAALTTAHAADVLHRDVKPDNIMFDGAGLLKVTDFGIAKIFDGAETTASAILGTPRYMAPEQILGGRLFPSTDLYALAGVLYEMLAERPLFGRPMGVQPLTHHHLNVMPDPLTMAPPQVAGVIMRTLAKDPAARLGDATEFALELARASVAAFGPAWLTRSDVKIRVDDEIREAALGTTSTPSSRFSGPPVGPPRPAGPQTPLPGTPGFPGYGPTGPPRPNQQFPPRPGMPTGPGYQPGPGRPVPTTGRPFTGTAPVGTPGGWSAPPATPQPTPPGPTPPAAPLPTPGYRPPAAGGWPPGGAPPVQPRPPQPMPPRPPLVPQPVRTPLPTPHRGQPRKGLFGLSLRTTLITATLLFVLIAGLTTAIALAFSRGGGGGGSGGDGVNTAQEPYPDRTRGLPATAIAYSGPTLTVPNLAPLHLFMGTDGSVYVSSLDTNIVHRISKDGTVTPIAGNGTAGFSGDGGPATSAELNGPGTAVVDKNGNIYVPDTANNRIRKITPDGKITTVVGNGTAGFSGDGGPATQAEINSVEGIAVGPDGSLYLADYSNERIRKVTPDGIISTIAGTGTKGYTSTPTPALSAQISDPNSVVIADDGTIYIGNLGSDSVQKIGKDGILSPFAGNGKTGRTGDGGDAANATLSIPDLALGPDGTVYISNYGSDTVRKVTPDGVITTIAGTGAEGNTGDGGPATAAQLKSPSSVVVDASGAVYIADNGNKEIRRVDPNGTISLIARQAS
>NC_014666.1|WP_013428212.1|8720173_8722588_+|protein-kinase
MTTPTPAPDLIAGALPGYEIGAELGRGGFGAVYAARHRLMGRAVAIKVLLDPGAAAGPDPFDGSGGSGGDLRTRFLAEARVLAELDHPHIVRVYDYVEHAGLCLLVMEQLTGGTLRTRIASTPPSRAGSAWTPSDQLARPGNLDPRSSCAIGLTAATALAAAHRIGVLHRDIKPDNLLFGADGMPRVADFGIAKIVESSTVTTTGLLGTPRYMAPEQIEGTRLGPGTDLYALGVVLYELLCGRPVFGRGLTVPALLHHHLSIPPDPMPEVPAPLAAVVLAALAKNPADRPASAHDLALMLAAGATAVFGPGWLAAAGIPARLPDDVLTAAGHRLGDLLPGMTPGWAPPGVSPTLAGPTTTPPYPMHTPRPGGPSPTDPPPGPPLTPTRVAPTPHGRRRRRPRRRGLLIGAGVTLVVVLLAVGLVVGLTAGGGGDAKPGYAGQQLTLDRGTFFDALALRRDGTVYVAVSDSGVGTGAVYEVTASGTVRAVAGVGPAPASSPTTTRTTTATTPPATTSPPPVPAAGVPAAQLVLNEVHGLAVAPDGTVYAADHAADQVYRIAPDGRAFVFAGTARGGGGFTADAGLATRAALDGPAAAALGPDGSVYVAEGSRIRKITKDGLISTVAGAYGRSSTTVIGDGGPATKASLPSPSGLAVTADGSIYVADDYLDTIREITPDGTIRTVAGTSGKDGETGDGGPAARALLSGPTGLALGPDGSLYITDTHNAKIRRIDPKGVMTTFAGTDSGVSTGLDGTSAGEAALTGLYGVVVDPSGAVYATLNQVGTLLRIDPANHIVRTLLAPPEK
>NC_014666.1|WP_013428213.1|8722686_8724288_+|FAD-binding-oxidoreductase
MGVVTDRRTVLRAGLAMLGGAVGTVAAGCSPGRSHAPTGPAASGSIASASGTPLGPAQSWDAFAGRLAGQLVRPTDSDYDRARALFDPAFDTVRPQGIAYAANPADVAEAVRFARATGVGLAARCGGHSYAGYSTSDGLVVDVTRMNQVSVASNGVATVGGGTRLIKLYTDLAGAGRSMAGGSCPTVGIAGLTLGGGIGVLGRLYGLTCDQLTGADVVLASGERLSVDENHDADLFWALRGGGGGNVGIVTAFRFATRPARSLTLFSVRWPWSAAADVITAWQQWITGRLGVMPDTLWSTVVAGSVPGGSAPTLRVSGVFAGDRTGLNGPLADLRAALRSVAPVSTTIVDHDYLTAMRLEGGCSASGDTCGSTAGISAGARRPGQKAASAILLSPIAPAGVDVLSRQVEARQRDPLAKASGGIILDSWGGAISKVSPSETAFVHRDAIASVQYFASYPAGATAENVRAAHGWVRDTAAAVAPYVSDQAYQNYIDPDLANWAQAYYGANLPRLTAIKRHYDPDNLFRFAQSIPS

Crispr_ID: NC_014666_19

• CRISPR_ID: NC_014666_19
• CRISPR_location: 8751745-8751863
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NC_014666_19

Consensus_repeat	Method
AACGATCTCCGCGTTCCGCGGAACG	CRISPRCasFinder

spacers of NC_014666_19

>19.1|8751770|17|NC_014666|CRISPRCasFinder
CGCACCGCAACCCGCGG
>19.2|8751812|26|NC_014666|CRISPRCasFinder
CGCACCGTCCCGCGGAACGCGGGCGG

CRISPR arrays and Neighbor proteins around NC_014666_19

CRISPR arrays

The CRISPR arrays of NC_014666_19

>merge|NC_014666|19|8751745-8751863|CRISPRCasFinder
AACGATCACCGCACCCCGCGGAACGCGCACCGCAACCCGCGGAACGCGCACCGCAACCCGCGGAACGCGCACCGTCCCGCGGAACGCGGGCGGGACGGGCACCGCGGAACGCGGAACGC

>NC_014666|19|16|8751745-8751863|CRISPRCasFinder
AACGATCACCGCACCCCGCGGAACG	CGCACCGCAACCCGCGG
AACGCGCACCGCAACCCGCGGAACG	CGCACCGTCCCGCGGAACGCGGGCGG
GACGGGCACCGCGGAACGCGGAACGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_014666.1|WP_157735636.1|8744614_8745634_+|L-histidine-N(alpha)-methyltransferase	unknown	unknown	gnl|CDD|378355
NC_014666.1|WP_013428228.1|8741904_8743434_+|ergothioneine-biosynthesis-protein-EgtB	unknown	unknown	gnl|CDD|274581
NC_014666.1|WP_013428231.1|8745731_8747585_-|dihydroxy-acid-dehydratase	unknown	unknown	gnl|CDD|237104
NC_014666.1|WP_041259852.1|8754765_8756124_-|replicative-DNA-helicase	unknown	unknown	gnl|CDD|273206
NC_014666.1|WP_013428235.1|8753042_8753543_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|379112
NC_014666.1|WP_013428226.1|8738974_8739775_-|NERD-domain-containing-protein	unknown	unknown	gnl|CDD|377990
NC_014666.1|WP_041259853.1|8758343_8758652_-|30S-ribosomal-protein-S6	unknown	unknown	gnl|CDD|179034
NC_014666.1|WP_007516941.1|8757373_8757610_-|30S-ribosomal-protein-S18	unknown	unknown	gnl|CDD|178997
NC_014666.1|WP_013428229.1|8743481_8744387_+|ergothioneine-biosynthesis-protein-EgtC	unknown	unknown	gnl|CDD|132483
NC_014666.1|WP_013428239.1|8757699_8758290_-|single-stranded-DNA-binding-protein	unknown	unknown	gnl|CDD|236092
NC_014666.1|WP_013428238.1|8756910_8757357_-|50S-ribosomal-protein-L9	unknown	unknown	gnl|CDD|234659
NC_014666.1|WP_013428233.1|8750693_8751047_+|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl|CDD|367760
NC_014666.1|WP_157735231.1|8758925_8759477_-|hypothetical-protein	unknown	unknown	unknown
NC_014666.1|WP_013428225.1|8737939_8738599_-|HNH-endonuclease	unknown	unknown	gnl|CDD|366837
NC_014666.1|WP_013428236.1|8753670_8754687_-|GTP-binding-protein	unknown	unknown	gnl|CDD|223597
NC_014666.1|WP_157735229.1|8736832_8737957_+|DNA-(cytosine-5-)-methyltransferase	unknown	unknown	gnl|CDD|223348
NC_014666.1|WP_157735638.1|8759872_8760973_-|hypothetical-protein	unknown	unknown	gnl|CDD|282094
NC_014666.1|WP_013428243.1|8761059_8763117_-|DUF2029-domain-containing-protein	unknown	unknown	gnl|CDD|227937
NC_014666.1|WP_157735637.1|8747932_8750512_-|protein-kinase	unknown	unknown	gnl|CDD|270916
NC_014666.1|WP_013428234.1|8751076_8751736_+|hypothetical-protein	unknown	unknown	gnl|CDD|236090

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_014666.1|WP_157735636.1|8744614_8745634_+|L-histidine-N(alpha)-methyltransferase	gnl|CDD|378355	pfam10017, Methyltransf_33, Histidine-specific methyltransferase, SAM-dependent. The mycobacterial members of this family are expressed from part of the ergothioneine biosynthetic gene cluster. EGTD is the histidine methyltransferase that transfers three methyl groups to the alpha-amino moiety of histidine, in the first stage of the production of this histidine betaine derivative that carries a thiol group attached to the C2 atom of an imidazole ring.	1.0395e-143
NC_014666.1|WP_013428228.1|8741904_8743434_+|ergothioneine-biosynthesis-protein-EgtB	gnl|CDD|274581	TIGR03440, egtB_TIGR03440, ergothioneine biosynthesis protein EgtB. Members of this family include EgtB, and enzyme of the ergothioneine biosynthesis, as found in numerous Actinobacteria. Characterized homologs to this family include a formylglycine-generating enzyme that serves as a maturase for an aerobic sulfatase (cf. the radical SAM enzymes that serve as anaerobic sulfatase maturases). [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	1.0192e-144
NC_014666.1|WP_013428231.1|8745731_8747585_-|dihydroxy-acid-dehydratase	gnl|CDD|237104	PRK12448, PRK12448, dihydroxy-acid dehydratase; Provisional.	0
NC_014666.1|WP_041259852.1|8754765_8756124_-|replicative-DNA-helicase	gnl|CDD|273206	TIGR00665, DnaB, replicative DNA helicase. This model describes the helicase DnaB, a homohexameric protein required for DNA replication. The homohexamer can form a ring around a single strand of DNA near a replication fork. An intein of > 400 residues is found at a conserved location in DnaB of Synechocystis PCC6803, Rhodothermus marinus (both experimentally confirmed), and Mycobacterium tuberculosis. The intein removes itself by a self-splicing reaction. The seed alignment contains inteins so that the model built from the seed alignment will model a low cost at common intein insertion sites. [DNA metabolism, DNA replication, recombination, and repair].	0
NC_014666.1|WP_013428235.1|8753042_8753543_-|GNAT-family-N-acetyltransferase	gnl|CDD|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	3.53748e-34
NC_014666.1|WP_013428226.1|8738974_8739775_-|NERD-domain-containing-protein	gnl|CDD|377990	pfam08378, NERD, Nuclease-related domain. The nuclease-related domain (NERD) is found in a range of bacterial as well as archaeal and plant proteins. It has distant similarity to endonucleases (hence its name) and its predicted secondary structure is helix - sheet - sheet - sheet - sheet - weak sheet/long loop - helix - sheet - sheet. The majority of NERD-containing proteins are single-domain, but in several cases proteins containing NERD have additional domains which in 75% of cases are involved in DNA processing.	5.74007e-11
NC_014666.1|WP_041259853.1|8758343_8758652_-|30S-ribosomal-protein-S6	gnl|CDD|179034	PRK00453, rpsF, 30S ribosomal protein S6; Reviewed.	6.47438e-38
NC_014666.1|WP_007516941.1|8757373_8757610_-|30S-ribosomal-protein-S18	gnl|CDD|178997	PRK00391, rpsR, 30S ribosomal protein S18; Reviewed.	1.85905e-37
NC_014666.1|WP_013428229.1|8743481_8744387_+|ergothioneine-biosynthesis-protein-EgtC	gnl|CDD|132483	TIGR03442, TIGR03442, ergothioneine biosynthesis protein EgtC. Members of this strictly bacterial protein family show similarity to class II glutamine amidotransferases (see pfam00310). They are distinguished by appearing in a genome context with, and usually adjacent to or between, members of families TIGR03438 (an uncharacterized methyltransferase) and TIGR03440 (an uncharacterized protein). [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	4.47864e-91
NC_014666.1|WP_013428239.1|8757699_8758290_-|single-stranded-DNA-binding-protein	gnl|CDD|236092	PRK07772, PRK07772, single-stranded DNA-binding protein; Provisional.	8.3018e-91
NC_014666.1|WP_013428238.1|8756910_8757357_-|50S-ribosomal-protein-L9	gnl|CDD|234659	PRK00137, rplI, 50S ribosomal protein L9; Reviewed.	1.714e-63
NC_014666.1|WP_013428233.1|8750693_8751047_+|antibiotic-biosynthesis-monooxygenase	gnl|CDD|367760	pfam03992, ABM, Antibiotic biosynthesis monooxygenase. This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.	6.62712e-13
NC_014666.1|WP_013428225.1|8737939_8738599_-|HNH-endonuclease	gnl|CDD|366837	pfam01844, HNH, HNH endonuclease. His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.	2.58727e-08
NC_014666.1|WP_013428236.1|8753670_8754687_-|GTP-binding-protein	gnl|CDD|223597	COG0523, COG0523, Putative GTPases (G3E family) [General function prediction only].	9.4747e-55
NC_014666.1|WP_157735229.1|8736832_8737957_+|DNA-(cytosine-5-)-methyltransferase	gnl|CDD|223348	COG0270, Dcm, Site-specific DNA methylase [DNA replication, recombination, and repair].	3.51114e-79
NC_014666.1|WP_157735638.1|8759872_8760973_-|hypothetical-protein	gnl|CDD|282094	pfam04188, Mannosyl_trans2, Mannosyltransferase (PIG-V). This is a family of eukaryotic ER membrane proteins that are involved in the synthesis of glycosylphosphatidylinositol (GPI), a glycolipid that anchors many proteins to the eukaryotic cell surface. Proteins in this family are involved in transferring the second mannose in the biosynthetic pathway of GPI.	0.000367977
NC_014666.1|WP_013428243.1|8761059_8763117_-|DUF2029-domain-containing-protein	gnl|CDD|227937	COG5650, COG5650, Predicted integral membrane protein [Function unknown].	1.23314e-21
NC_014666.1|WP_157735637.1|8747932_8750512_-|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.53651e-79
NC_014666.1|WP_013428234.1|8751076_8751736_+|hypothetical-protein	gnl|CDD|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	9.18523e-06

Protein sequences

>NC_014666.1|WP_013428234.1|8751076_8751736_+|hypothetical-protein
MGEFFKQFFGFLVFSPLTAAVFGFGIWILPAVFLRDVVARLRLRFFHFFVSGYVFIAIMTIYLLAAGSRTKTGDRHHQAGPFVGMLASLALAWWLNRLLRTRFPRRNPGGTNGSGVAAGQQPGYPGAHQHGYPGPNQPGYGHPAYRPPGYGQQPGYPPHPGYPGYPAYGPPQPAPPVQPSNQPPAHPDADGIPNQPRTPGVPWVVPPPADPAPPTTPPE
>NC_014666.1|WP_013428233.1|8750693_8751047_+|antibiotic-biosynthesis-monooxygenase
MSATGPAAGGTPVTEIARFDVKPGTESDFIVAYRTVRHEIATAPGCRSIRMSRGVESPSSFVLIVEWASLEAHTEGFRGSEGFGRWRAAIGPFFAGTPSVEHVASVEASAEATAGAV
>NC_014666.1|WP_157735637.1|8747932_8750512_-|protein-kinase
MVVGDSAVGSQLVEPLDEDDPTRLGPYLLLGRLGQGGMGTVYLGRRTGVNGSGLLAEAAVQSPQDDGKTGENGTGPLVAVKMVRPDLAREPEFRERFGREATAARRVARFCTAEVLDVDVESRRPYLVTEYIEGRTLAATVRQDGPLSSAEVERLAVAVASALTAIHAAGLVHRDLKPGNIMLSPSGARVIDFGIARALDATTTFTHAGVGTPAFMAPEQALGAVVAPPADIYAWGGVLLFAATGRLPHGEGPSPVILYRAVNDEPDLSGLEPGLRQLVARAMAKDPDRRPTAQELLLHLVGARPLDGLDGPSAAVLDSAPAGDLDEALALAAEIARDFGDDTLGTHDASGPGGQNAPGRPAALDDPAAPGNLAAPGGAAAPGGQIAPGGATALGGATAADGATAPGDPTAPSDPTGPGDLMGPAGGRSTAPADQDSRSRPAAGPARGTAGGPVTPTATPSPRAVTTDPPTRDATTFVPSHLRADGDRSDEPSRRRDGEPVTGVTARRRSGRLFAGRRGAAGGTVNATPLGEPLAGHTGHVESVAFAPGGGVLASGGADGTVRRWRLAEEAPGPDVAIPLGEPLRGHEGRVLAVAYAPDGTALATAGSDHTVRVWRQPAVEATGPSARMPAIGLGHTDQVTAVAFSPLGRFLATGSLDGTARLWELDPGERDPAASGRGVVRQFGQPLGGHQGKVLAVAFSPDGGLLATAGTDHTALLWDLTATVPRPVGPPLAGHRWHVQALAFTQDGRVLVAGAGFGAVHLWDVDKPDRPYPLAQVTSRGNGQIRSVALSADGRTLAAAGGIGAAVQLWTLDDLTSPEPLGQLATGHVGTVRALAFSPTSDTLATAGDNTVRLWQPS
>NC_014666.1|WP_013428231.1|8745731_8747585_-|dihydroxy-acid-dehydratase
MPALRSRTTTHGRNMAGARALWRATGMTEDDFGKPIVAIANSFTQFVPGHVHLRDLGKLVADSVAAAGGVGREFNTIAVDDGIAMGHGGMLYSLPSREIIADSVEYMVNAHCADALVCISNCDKITPGMLLAALRLNIPTVFVSGGAMESGNAVVQNGTVRSRLDLIDAMSAAVNPDVSDADLGIIERSACPTCGSCSGMFTANSMNCLTEALGLALPGNGSTLATAAARKELFVEAGRLVVDLARRYYEKDDEGVLPRSIASAAAFRNAFAVDVAMGGSTNTVLHLLAAAVEAEVPVDLHDIDEISRRVPNLCKVAPSSTKYYMEDVHRAGGIPAILGELDRAGLLDRGVHSVHSASLREFLDRWDIRSASPAPDAVELFHAAPGGVRTVEPFSSTNRWDTLDTDAVDGCIRSAEHAYSAEGGLAVLHGNLADDGAVVKTAGVPEDQWVFAGPAVVVESQEAAVEAILGNRVKPGDVVVVRYEGPRGGPGMQEMLYPTAYLKGRGLGPKCALITDGRFSGGSSGLSIGHVSPEAAHGGTIALVRDGDRIEIDIPARRIELMVPEAELASRRAELEAGNGYRPVNRERTVSAALRAYAAMATSAATGAARDVSLLGG
>NC_014666.1|WP_157735636.1|8744614_8745634_+|L-histidine-N(alpha)-methyltransferase
MTIERHLTDAQRTAALAADVRRGLAATPKELPPTWFYDTTGSMLFGKITELPEYYQTRAERAILATHAAQLATELETAVPGGVDSLVELGSGTSEKTRTLLAALAGTGRLRRFIPFDVDAEALSRAGAAARANHPGLAVHAVVGDFRQHLGLLPIQPAGGTLVAFLGGAIGNLRPPERAALLTELRSGLDQANGSREHGGRAQALLLGTDLVKEPARLVAAYDDSAGVTAAFNRNLLTVLNRELGADFDLRGFAHVAHWDAENRWIEMRLRSVKAQTVKVTALDLTVEFAEGEEIRTEISAKFDHAMVERELAAAGWRLAQWWADPDGDFALSLAIAAA
>NC_014666.1|WP_013428229.1|8743481_8744387_+|ergothioneine-biosynthesis-protein-EgtC
MCRHLAWLGADRTLADLLLRRPSGLLQQSWAPRQQRHGRVNADGFGVGWYVPALRPQPARYRRAVPMWTDASFASFAEVVASGCVLAAVRDATVGMPIEETSTAPFTHGPLLLSHNGRVSVDVLLALLAGRPDAPPPDSRCDSALLAALVWERALAGLTLADAVAEVVTTVGAKAAAREASRAAGDAGQQPPSRLNVLVTDGRQIVATTWDDTLWYRVSSAGVLVASEPDDDAPMVRVPGGAESVSEGRASAESHPATELHPGNGTDVWVEVPNHRLLVADTRKVTVSNLISQDGYSGFTT
>NC_014666.1|WP_013428228.1|8741904_8743434_+|ergothioneine-biosynthesis-protein-EgtB
MAGSAVPAHPGPTTAEPATADEGTDLSGGLAAGGSHPAPVPAGPAGWAEALERSRRRTLTYTDLDDDLLIRQHSPLMSPLVWDLAHIGNYEELWLLRALTGADPLLPGIDDLYDAFRHPRADRPALPLLPPDQARGYIADVRSRVLDAMAALDSRSVDSRPAGWGGQRDDVVTRLLSGGFVYGMVVQHEHQHDETLLATLQLATAARVQPRPARDPVVDEGVALPAGRPVSGEVLVPAGPFTMGTSTDPWAYDNERPAHRVDVPAFWIDRLPVSNRAQLAFLDAGGYDDERLWSPAGWAWRCRERLEAPLFWRRDGAGGWLRRRFGRDEALPLDEPVQHVCWYEAEAHARWAGRRLPTETEWEKACAFDPASGRSRRFPWGDDPPTPRHANLGHRAARPAPLGAYPDGASASGVEQMIGDVWEWTSSGFTAYPGFAAFPYREYSEVFFRGPDGVERADADPDQQFRGYRVLRGGSWAADPSAARATFRNWDHPIRRQIFVGFRLARDAD
>NC_014666.1|WP_013428226.1|8738974_8739775_-|NERD-domain-containing-protein
MAEYRRRRALYVAERDDRRVRAAIIAGSAAVGAALVVVLIGISLHGAAAVLVRSGVAAALLVLVVAAVRFFRIPPEIEAWRRDAGAERRTARALDRLNRAGYTVLHDRSTADSAGNIDHLIIGASGVWVIETDAHRGPVRSSGGGVWAGKAPLRARLGLVAWTGEQVSAALLAELPEGWQLQAQTVLAFARADVPGGLALVDGVLLLPAAGVAEYVLSAGVVLRPLDVAMLVDVAQRALPAYEVAGPPPTWSALSKLRGLRRREQL
>NC_014666.1|WP_013428225.1|8737939_8738599_-|HNH-endonuclease
MTDELFPIPEPLVRPVIALPPHLKELIDLLPLNTPVHRRDLEAKYGRSNYARRIRKIISEYGWEIESRRQSEGANDDWYIRRSDGPVRPQRIRREVPRRSRETVYRRDDWICQICRMKTDPERGSLVPQCDHKIPADRGGDSDEENLQTLCTRCNLKKRQACGGCALASCADCPFAYPEKFDDVLILHLDREHLKRIMTTAYARNVTASAVVSDLSDLL
>NC_014666.1|WP_157735229.1|8736832_8737957_+|DNA-(cytosine-5-)-methyltransferase
MRSGHGALRAIGATKDSELVSSESKPTLIDLFCGAGGMTLGFMQAGFQPILSIDHDLPSIETHRANFPGMSICTDIRDFVDFPSADVVVGGPPCQGFSRLGKQARKERLENFLWKDYMRCVASSKPSVFVIENVPEFLKDPAFLGVSEESEKLGYKLTVSVLNAADFGVPQRRQRTIMIGSRIGPPSLPRATHQKPGDQMNLFTELPTWRTVRDAIGDLPLEPTNENLHNSRNVSKLSLERYRHVPPGGNRKDLPEDLQPDCWRYKDPRGGGSTDLMGRLEWDAPSLTIRTQFLKPEKGRYLHPAADRSITVREGARLQTFPDDFKFTGSVFQTVKQIGNAVPVELARQVALEVFQHMASNCYEWGNHPLEQVG
>NC_014666.1|WP_013428235.1|8753042_8753543_-|GNAT-family-N-acetyltransferase
MLETDRLVLRPLRLADVDAFLALHADDRVNRFVGTYTRDQALVRLETVEKQWADRGHGLFSVHLKTTGEFVGRIGPQFWDEFGEVEMAWTLRAEAWGRGYATEAAQACIDWAFEHLTENYLAAYIHPENAASHRVAQRLGFSVLRHGILFDKPVIVYALNRPTTRA
>NC_014666.1|WP_013428236.1|8753670_8754687_-|GTP-binding-protein
MGQRVPVIALTGYLGAGKTTVLNHLLRAPGARIGVVVNDFGAINVDAALITGQVDEPAAITGGCVCCVPDTDGLDDALEKLTQPRLRLDAVLVEASGVADPPALARLIQFSGVRRARPGGLVDVIDAAAYFDTVDSGGPPPARFSAASLVVINKTDRVATEVRAETVARIAARVREANPRAHLVDTTHGRVDPALVFDAATTEDPVDELPFAAAARQDPGEESHRHVHAVTVPATGPIDPGPLVDLLEDPPAGAYRLKGTVTVDTGRGPRGFVVNIVGPQIHVAARPSSDGPDGLVAIGLHLDQAAARARLEEVLRPCSGRPAAEGVRRFTRYRRLSS
>NC_014666.1|WP_041259852.1|8754765_8756124_-|replicative-DNA-helicase
MTVTDISRGGGQPLELDRTPPHDIPAEQSVLGGMLLSKDAIADVVEVLRATDFYRPAHATVFEVVGDLYGRGEPADTVSVAAELGRRELLERVGGAGYLHTLISSVPTAANAGYYAHIVAEKAVLRRLAEAGTRIVQLAYGPAHDVDALVDRAQAAVYDVTERRGTDDYAPLGDLLNPALEEIEAIAGHEGALTGVPTGFADLDELTNGLHGGQLWIVAARPAVGKSTLGLDFARAASIKHGMASVIFSLEMSRMEITMRLLSAEARVSLQNIRTGRLTDEDWARLARRMGEVAEAPLFIDDSPNLTMMEIRAKARRLRQRNDLRLIILDYLQLMSSPKRVESRQQEVSEISRSLKLLAKELEIPVVAISQLNRASEQRADKRPQVSDLRESGSLEQDADAVILLYREDTVEKESARAGEADLIIAKHRNGPTGTVTVAFQGHYSRFVDMAN
>NC_014666.1|WP_013428238.1|8756910_8757357_-|50S-ribosomal-protein-L9
MKLVLTHEVPGLGSPGDIVEVADGYGRNYLVPKQFAIVATRGVERQVDQIKRARSAREVRDLGHAQEIAEQLKALSVTLVSRAGKEGRLFGSITAGDVTDAVTRAGGPALDKRKVQLTSPIKSLGQHTVAVHLHPEVTAQVTVRVSAA
>NC_014666.1|WP_007516941.1|8757373_8757610_-|30S-ribosomal-protein-S18
MAKAAVRKPKKKVCVFCKDKTEYIDYKDTSLLRKFISDRGKIRARRVTGNCSQHQRDVAIAVKNSREMALLPYTSTAR
>NC_014666.1|WP_013428239.1|8757699_8758290_-|single-stranded-DNA-binding-protein
MAGETVITVVGNLTSDPELRFTPNGAAVASFTVASTPRTLDRATNEWKDGEALFLRCSIWRQAAEHVAESLQKGARVIVQGRLKQRTFETREGEKRTVIELDVDEIGPSLRYATAKVVRAARGGGPGGGGGFDGGGYSGGGPSGGAGGASAGGAGGGGGYRGGGQGGSSSGGGYSGGAVDDPWSQSAGGYSDEPPF
>NC_014666.1|WP_041259853.1|8758343_8758652_-|30S-ribosomal-protein-S6
MVILDPDLEERTVSPSLDQFLSVVRNGGGAVEKVDVWGRRRLAYEIRKSHEGIYAVIDLHAEPDVVAELDRQLTLNESVIRTKVIRLPEAKKPRAARRPVAA
>NC_014666.1|WP_157735231.1|8758925_8759477_-|hypothetical-protein
MSTDGDPAGPPADGAPAHEPRPAPAAPADRAGIEAGDAAPRDVGPVAPERPGGGLGAVSRRWKATSPPGAGSRRDAGPRRQFTERERAINALAYPVAGTAAAAVVVVIVVALVDPSPGRHVRGLLILLALVGLLAAACGWVRTVWHGPTDDPGADAATDGPSSPAHSAARPQGGERQIVRHVE
>NC_014666.1|WP_157735638.1|8759872_8760973_-|hypothetical-protein
MRATLPVWFASRVGVAVLSYAAARVAVEGALGRQPTFLALWDRWDVGLFTKVARYGYVSPHYADQTEVDFPAFPLAIRLVHLFTRSWLASGLIVVFLAGAVAMAAIWRLAADEDGPEAGRAAVLAAIFAPYAVFLFAGYSEALFLAFASTAWLAGRRGHWWVAGLLAAGATGTRITGIPLWCGLVVLYLVERRSAGQPVLARPAFALALPPLPVFGFLWYLHGKTGEWNAYTVAMRAGWHRWTDWPWSGWRATWHSAFPGPDGSTTFTWFWRAELLAVVLGVVVTILLLRGRRWAEATFVGTATLLMAATNYYASGVRTMLVAFPVYLLLARLAGRYPRLAPAYLWLSGPVMAAFVVAFTQGHWVD
>NC_014666.1|WP_013428243.1|8761059_8763117_-|DUF2029-domain-containing-protein
MTAADVVDATVSPSDEDPVVRGASELVGGPPGRHAALPASTWWTPLRVLLALTIVVCGLGYTQKATCRDTRNWAHEYQYTRMCYSDVVALYSQEGLSGGKTPYLDYPTEYPPLIGLTMEVVGAVSRLAPTQHPVYKTVNGQQVVDHYTMDSRSALFYDLTWVLFLGLACVTVVATALTAGRRRIWDAALFALAPTMVLHLLTNWDIIAVAFAALAIYAWSRRMPVVAGVMLGLGVCTKLYPIFFLVGLFVLCLRTGYLRTFARTAIATAATIVAIMLPTWLVAGYFVGTQKVQDGILPTFFSGGDWLSLLGGHGPDGSRNAVEQFFHLNETRVADWDSVAFALQWLSGAHDPGWFAGLHLVVVLLSGLLLAGAVVLVRYRAERARWAAGPEEPERAQGLLDAPRVQVAVAGGTWLVIVIATPLVLTAIREHGVPVHVLNWVTAVVLLMVVAAICALCWFAPRRPRLPQVLFLLVVAFLVTNKVFSPQYTLWLVPLYALARPKWRAFLVWQATEAYLLFMRFMHFIYNDTSGGRGVARGWFVGAVALRDLMLVVLAGLVVREILRPELDVVRASGLDDPAGGVLDGAADAAVGRGRAVRRDYAPSERPPSERPPAPEPSPTVPEYAETGPLPSLGRRWRRAEAVGDTGATQTGTGTSGRGGETGGDGGLSEPGALFKPRRTDPDAP

Crispr_ID: NC_014666_20

• CRISPR_ID: NC_014666_20
• CRISPR_location: 8752015-8752266
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 3 spacers

Consensus repeat of NC_014666_20

Consensus_repeat	Method
AACGATCTCCGCGTTCCGCGGAACG	CRISPRCasFinder

spacers of NC_014666_20

>20.1|8752040|55|NC_014666|CRISPRCasFinder
CGGCCGACCCAACGACGGGCTCCCTGAATCCTGGAGACACGACGCGGGCACCGCC
>20.2|8752120|59|NC_014666|CRISPRCasFinder
GTCGGCGCGCGGACGCCACGGAGGCCCAAGGCTTCGTCGGAACGTCAGCCAGCCGGCCA
>20.3|8752204|38|NC_014666|CRISPRCasFinder
CCAGACGACCTCCTCGTTCCGCTGGAACGGGTGCCGCA

CRISPR arrays and Neighbor proteins around NC_014666_20

CRISPR arrays

The CRISPR arrays of NC_014666_20

>merge|NC_014666|20|8752015-8752266|CRISPRCasFinder
GACGACCAGCCCGCTCGGCGGAACGCGGCCGACCCAACGACGGGCTCCCTGAATCCTGGAGACACGACGCGGGCACCGCCAACGATCTCCGCGTTCCGCGGAACGGTCGGCGCGCGGACGCCACGGAGGCCCAAGGCTTCGTCGGAACGTCAGCCAGCCGGCCAAACGATCTCCGCGTTCCGCGGAACGCCAGACGACCTCCTCGTTCCGCTGGAACGGGTGCCGCAGACGATCCTCGCGTTCCGCGGAACG

>NC_014666|20|17|8752015-8752266|CRISPRCasFinder
GACGACCAGCCCGCTCGGCGGAACG	CGGCCGACCCAACGACGGGCTCCCTGAATCCTGGAGACACGACGCGGGCACCGCC
AACGATCTCCGCGTTCCGCGGAACG	GTCGGCGCGCGGACGCCACGGAGGCCCAAGGCTTCGTCGGAACGTCAGCCAGCCGGCCA
AACGATCTCCGCGTTCCGCGGAACG	CCAGACGACCTCCTCGTTCCGCTGGAACGGGTGCCGCA
GACGATCCTCGCGTTCCGCGGAACG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_014666.1|WP_157735636.1|8744614_8745634_+|L-histidine-N(alpha)-methyltransferase	unknown	unknown	gnl|CDD|378355
NC_014666.1|WP_013428228.1|8741904_8743434_+|ergothioneine-biosynthesis-protein-EgtB	unknown	unknown	gnl|CDD|274581
NC_014666.1|WP_013428231.1|8745731_8747585_-|dihydroxy-acid-dehydratase	unknown	unknown	gnl|CDD|237104
NC_014666.1|WP_041259852.1|8754765_8756124_-|replicative-DNA-helicase	unknown	unknown	gnl|CDD|273206
NC_014666.1|WP_013428235.1|8753042_8753543_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|379112
NC_014666.1|WP_013428226.1|8738974_8739775_-|NERD-domain-containing-protein	unknown	unknown	gnl|CDD|377990
NC_014666.1|WP_041259853.1|8758343_8758652_-|30S-ribosomal-protein-S6	unknown	unknown	gnl|CDD|179034
NC_014666.1|WP_007516941.1|8757373_8757610_-|30S-ribosomal-protein-S18	unknown	unknown	gnl|CDD|178997
NC_014666.1|WP_013428229.1|8743481_8744387_+|ergothioneine-biosynthesis-protein-EgtC	unknown	unknown	gnl|CDD|132483
NC_014666.1|WP_013428239.1|8757699_8758290_-|single-stranded-DNA-binding-protein	unknown	unknown	gnl|CDD|236092
NC_014666.1|WP_013428238.1|8756910_8757357_-|50S-ribosomal-protein-L9	unknown	unknown	gnl|CDD|234659
NC_014666.1|WP_013428233.1|8750693_8751047_+|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl|CDD|367760
NC_014666.1|WP_157735231.1|8758925_8759477_-|hypothetical-protein	unknown	unknown	unknown
NC_014666.1|WP_013428225.1|8737939_8738599_-|HNH-endonuclease	unknown	unknown	gnl|CDD|366837
NC_014666.1|WP_013428236.1|8753670_8754687_-|GTP-binding-protein	unknown	unknown	gnl|CDD|223597
NC_014666.1|WP_157735229.1|8736832_8737957_+|DNA-(cytosine-5-)-methyltransferase	unknown	unknown	gnl|CDD|223348
NC_014666.1|WP_157735638.1|8759872_8760973_-|hypothetical-protein	unknown	unknown	gnl|CDD|282094
NC_014666.1|WP_013428243.1|8761059_8763117_-|DUF2029-domain-containing-protein	unknown	unknown	gnl|CDD|227937
NC_014666.1|WP_157735637.1|8747932_8750512_-|protein-kinase	unknown	unknown	gnl|CDD|270916
NC_014666.1|WP_013428234.1|8751076_8751736_+|hypothetical-protein	unknown	unknown	gnl|CDD|236090

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_014666.1|WP_157735636.1|8744614_8745634_+|L-histidine-N(alpha)-methyltransferase	gnl|CDD|378355	pfam10017, Methyltransf_33, Histidine-specific methyltransferase, SAM-dependent. The mycobacterial members of this family are expressed from part of the ergothioneine biosynthetic gene cluster. EGTD is the histidine methyltransferase that transfers three methyl groups to the alpha-amino moiety of histidine, in the first stage of the production of this histidine betaine derivative that carries a thiol group attached to the C2 atom of an imidazole ring.	1.0395e-143
NC_014666.1|WP_013428228.1|8741904_8743434_+|ergothioneine-biosynthesis-protein-EgtB	gnl|CDD|274581	TIGR03440, egtB_TIGR03440, ergothioneine biosynthesis protein EgtB. Members of this family include EgtB, and enzyme of the ergothioneine biosynthesis, as found in numerous Actinobacteria. Characterized homologs to this family include a formylglycine-generating enzyme that serves as a maturase for an aerobic sulfatase (cf. the radical SAM enzymes that serve as anaerobic sulfatase maturases). [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	1.0192e-144
NC_014666.1|WP_013428231.1|8745731_8747585_-|dihydroxy-acid-dehydratase	gnl|CDD|237104	PRK12448, PRK12448, dihydroxy-acid dehydratase; Provisional.	0
NC_014666.1|WP_041259852.1|8754765_8756124_-|replicative-DNA-helicase	gnl|CDD|273206	TIGR00665, DnaB, replicative DNA helicase. This model describes the helicase DnaB, a homohexameric protein required for DNA replication. The homohexamer can form a ring around a single strand of DNA near a replication fork. An intein of > 400 residues is found at a conserved location in DnaB of Synechocystis PCC6803, Rhodothermus marinus (both experimentally confirmed), and Mycobacterium tuberculosis. The intein removes itself by a self-splicing reaction. The seed alignment contains inteins so that the model built from the seed alignment will model a low cost at common intein insertion sites. [DNA metabolism, DNA replication, recombination, and repair].	0
NC_014666.1|WP_013428235.1|8753042_8753543_-|GNAT-family-N-acetyltransferase	gnl|CDD|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	3.53748e-34
NC_014666.1|WP_013428226.1|8738974_8739775_-|NERD-domain-containing-protein	gnl|CDD|377990	pfam08378, NERD, Nuclease-related domain. The nuclease-related domain (NERD) is found in a range of bacterial as well as archaeal and plant proteins. It has distant similarity to endonucleases (hence its name) and its predicted secondary structure is helix - sheet - sheet - sheet - sheet - weak sheet/long loop - helix - sheet - sheet. The majority of NERD-containing proteins are single-domain, but in several cases proteins containing NERD have additional domains which in 75% of cases are involved in DNA processing.	5.74007e-11
NC_014666.1|WP_041259853.1|8758343_8758652_-|30S-ribosomal-protein-S6	gnl|CDD|179034	PRK00453, rpsF, 30S ribosomal protein S6; Reviewed.	6.47438e-38
NC_014666.1|WP_007516941.1|8757373_8757610_-|30S-ribosomal-protein-S18	gnl|CDD|178997	PRK00391, rpsR, 30S ribosomal protein S18; Reviewed.	1.85905e-37
NC_014666.1|WP_013428229.1|8743481_8744387_+|ergothioneine-biosynthesis-protein-EgtC	gnl|CDD|132483	TIGR03442, TIGR03442, ergothioneine biosynthesis protein EgtC. Members of this strictly bacterial protein family show similarity to class II glutamine amidotransferases (see pfam00310). They are distinguished by appearing in a genome context with, and usually adjacent to or between, members of families TIGR03438 (an uncharacterized methyltransferase) and TIGR03440 (an uncharacterized protein). [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	4.47864e-91
NC_014666.1|WP_013428239.1|8757699_8758290_-|single-stranded-DNA-binding-protein	gnl|CDD|236092	PRK07772, PRK07772, single-stranded DNA-binding protein; Provisional.	8.3018e-91
NC_014666.1|WP_013428238.1|8756910_8757357_-|50S-ribosomal-protein-L9	gnl|CDD|234659	PRK00137, rplI, 50S ribosomal protein L9; Reviewed.	1.714e-63
NC_014666.1|WP_013428233.1|8750693_8751047_+|antibiotic-biosynthesis-monooxygenase	gnl|CDD|367760	pfam03992, ABM, Antibiotic biosynthesis monooxygenase. This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.	6.62712e-13
NC_014666.1|WP_013428225.1|8737939_8738599_-|HNH-endonuclease	gnl|CDD|366837	pfam01844, HNH, HNH endonuclease. His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.	2.58727e-08
NC_014666.1|WP_013428236.1|8753670_8754687_-|GTP-binding-protein	gnl|CDD|223597	COG0523, COG0523, Putative GTPases (G3E family) [General function prediction only].	9.4747e-55
NC_014666.1|WP_157735229.1|8736832_8737957_+|DNA-(cytosine-5-)-methyltransferase	gnl|CDD|223348	COG0270, Dcm, Site-specific DNA methylase [DNA replication, recombination, and repair].	3.51114e-79
NC_014666.1|WP_157735638.1|8759872_8760973_-|hypothetical-protein	gnl|CDD|282094	pfam04188, Mannosyl_trans2, Mannosyltransferase (PIG-V). This is a family of eukaryotic ER membrane proteins that are involved in the synthesis of glycosylphosphatidylinositol (GPI), a glycolipid that anchors many proteins to the eukaryotic cell surface. Proteins in this family are involved in transferring the second mannose in the biosynthetic pathway of GPI.	0.000367977
NC_014666.1|WP_013428243.1|8761059_8763117_-|DUF2029-domain-containing-protein	gnl|CDD|227937	COG5650, COG5650, Predicted integral membrane protein [Function unknown].	1.23314e-21
NC_014666.1|WP_157735637.1|8747932_8750512_-|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.53651e-79
NC_014666.1|WP_013428234.1|8751076_8751736_+|hypothetical-protein	gnl|CDD|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	9.18523e-06

Protein sequences

>NC_014666.1|WP_013428234.1|8751076_8751736_+|hypothetical-protein
MGEFFKQFFGFLVFSPLTAAVFGFGIWILPAVFLRDVVARLRLRFFHFFVSGYVFIAIMTIYLLAAGSRTKTGDRHHQAGPFVGMLASLALAWWLNRLLRTRFPRRNPGGTNGSGVAAGQQPGYPGAHQHGYPGPNQPGYGHPAYRPPGYGQQPGYPPHPGYPGYPAYGPPQPAPPVQPSNQPPAHPDADGIPNQPRTPGVPWVVPPPADPAPPTTPPE
>NC_014666.1|WP_013428233.1|8750693_8751047_+|antibiotic-biosynthesis-monooxygenase
MSATGPAAGGTPVTEIARFDVKPGTESDFIVAYRTVRHEIATAPGCRSIRMSRGVESPSSFVLIVEWASLEAHTEGFRGSEGFGRWRAAIGPFFAGTPSVEHVASVEASAEATAGAV
>NC_014666.1|WP_157735637.1|8747932_8750512_-|protein-kinase
MVVGDSAVGSQLVEPLDEDDPTRLGPYLLLGRLGQGGMGTVYLGRRTGVNGSGLLAEAAVQSPQDDGKTGENGTGPLVAVKMVRPDLAREPEFRERFGREATAARRVARFCTAEVLDVDVESRRPYLVTEYIEGRTLAATVRQDGPLSSAEVERLAVAVASALTAIHAAGLVHRDLKPGNIMLSPSGARVIDFGIARALDATTTFTHAGVGTPAFMAPEQALGAVVAPPADIYAWGGVLLFAATGRLPHGEGPSPVILYRAVNDEPDLSGLEPGLRQLVARAMAKDPDRRPTAQELLLHLVGARPLDGLDGPSAAVLDSAPAGDLDEALALAAEIARDFGDDTLGTHDASGPGGQNAPGRPAALDDPAAPGNLAAPGGAAAPGGQIAPGGATALGGATAADGATAPGDPTAPSDPTGPGDLMGPAGGRSTAPADQDSRSRPAAGPARGTAGGPVTPTATPSPRAVTTDPPTRDATTFVPSHLRADGDRSDEPSRRRDGEPVTGVTARRRSGRLFAGRRGAAGGTVNATPLGEPLAGHTGHVESVAFAPGGGVLASGGADGTVRRWRLAEEAPGPDVAIPLGEPLRGHEGRVLAVAYAPDGTALATAGSDHTVRVWRQPAVEATGPSARMPAIGLGHTDQVTAVAFSPLGRFLATGSLDGTARLWELDPGERDPAASGRGVVRQFGQPLGGHQGKVLAVAFSPDGGLLATAGTDHTALLWDLTATVPRPVGPPLAGHRWHVQALAFTQDGRVLVAGAGFGAVHLWDVDKPDRPYPLAQVTSRGNGQIRSVALSADGRTLAAAGGIGAAVQLWTLDDLTSPEPLGQLATGHVGTVRALAFSPTSDTLATAGDNTVRLWQPS
>NC_014666.1|WP_013428231.1|8745731_8747585_-|dihydroxy-acid-dehydratase
MPALRSRTTTHGRNMAGARALWRATGMTEDDFGKPIVAIANSFTQFVPGHVHLRDLGKLVADSVAAAGGVGREFNTIAVDDGIAMGHGGMLYSLPSREIIADSVEYMVNAHCADALVCISNCDKITPGMLLAALRLNIPTVFVSGGAMESGNAVVQNGTVRSRLDLIDAMSAAVNPDVSDADLGIIERSACPTCGSCSGMFTANSMNCLTEALGLALPGNGSTLATAAARKELFVEAGRLVVDLARRYYEKDDEGVLPRSIASAAAFRNAFAVDVAMGGSTNTVLHLLAAAVEAEVPVDLHDIDEISRRVPNLCKVAPSSTKYYMEDVHRAGGIPAILGELDRAGLLDRGVHSVHSASLREFLDRWDIRSASPAPDAVELFHAAPGGVRTVEPFSSTNRWDTLDTDAVDGCIRSAEHAYSAEGGLAVLHGNLADDGAVVKTAGVPEDQWVFAGPAVVVESQEAAVEAILGNRVKPGDVVVVRYEGPRGGPGMQEMLYPTAYLKGRGLGPKCALITDGRFSGGSSGLSIGHVSPEAAHGGTIALVRDGDRIEIDIPARRIELMVPEAELASRRAELEAGNGYRPVNRERTVSAALRAYAAMATSAATGAARDVSLLGG
>NC_014666.1|WP_157735636.1|8744614_8745634_+|L-histidine-N(alpha)-methyltransferase
MTIERHLTDAQRTAALAADVRRGLAATPKELPPTWFYDTTGSMLFGKITELPEYYQTRAERAILATHAAQLATELETAVPGGVDSLVELGSGTSEKTRTLLAALAGTGRLRRFIPFDVDAEALSRAGAAARANHPGLAVHAVVGDFRQHLGLLPIQPAGGTLVAFLGGAIGNLRPPERAALLTELRSGLDQANGSREHGGRAQALLLGTDLVKEPARLVAAYDDSAGVTAAFNRNLLTVLNRELGADFDLRGFAHVAHWDAENRWIEMRLRSVKAQTVKVTALDLTVEFAEGEEIRTEISAKFDHAMVERELAAAGWRLAQWWADPDGDFALSLAIAAA
>NC_014666.1|WP_013428229.1|8743481_8744387_+|ergothioneine-biosynthesis-protein-EgtC
MCRHLAWLGADRTLADLLLRRPSGLLQQSWAPRQQRHGRVNADGFGVGWYVPALRPQPARYRRAVPMWTDASFASFAEVVASGCVLAAVRDATVGMPIEETSTAPFTHGPLLLSHNGRVSVDVLLALLAGRPDAPPPDSRCDSALLAALVWERALAGLTLADAVAEVVTTVGAKAAAREASRAAGDAGQQPPSRLNVLVTDGRQIVATTWDDTLWYRVSSAGVLVASEPDDDAPMVRVPGGAESVSEGRASAESHPATELHPGNGTDVWVEVPNHRLLVADTRKVTVSNLISQDGYSGFTT
>NC_014666.1|WP_013428228.1|8741904_8743434_+|ergothioneine-biosynthesis-protein-EgtB
MAGSAVPAHPGPTTAEPATADEGTDLSGGLAAGGSHPAPVPAGPAGWAEALERSRRRTLTYTDLDDDLLIRQHSPLMSPLVWDLAHIGNYEELWLLRALTGADPLLPGIDDLYDAFRHPRADRPALPLLPPDQARGYIADVRSRVLDAMAALDSRSVDSRPAGWGGQRDDVVTRLLSGGFVYGMVVQHEHQHDETLLATLQLATAARVQPRPARDPVVDEGVALPAGRPVSGEVLVPAGPFTMGTSTDPWAYDNERPAHRVDVPAFWIDRLPVSNRAQLAFLDAGGYDDERLWSPAGWAWRCRERLEAPLFWRRDGAGGWLRRRFGRDEALPLDEPVQHVCWYEAEAHARWAGRRLPTETEWEKACAFDPASGRSRRFPWGDDPPTPRHANLGHRAARPAPLGAYPDGASASGVEQMIGDVWEWTSSGFTAYPGFAAFPYREYSEVFFRGPDGVERADADPDQQFRGYRVLRGGSWAADPSAARATFRNWDHPIRRQIFVGFRLARDAD
>NC_014666.1|WP_013428226.1|8738974_8739775_-|NERD-domain-containing-protein
MAEYRRRRALYVAERDDRRVRAAIIAGSAAVGAALVVVLIGISLHGAAAVLVRSGVAAALLVLVVAAVRFFRIPPEIEAWRRDAGAERRTARALDRLNRAGYTVLHDRSTADSAGNIDHLIIGASGVWVIETDAHRGPVRSSGGGVWAGKAPLRARLGLVAWTGEQVSAALLAELPEGWQLQAQTVLAFARADVPGGLALVDGVLLLPAAGVAEYVLSAGVVLRPLDVAMLVDVAQRALPAYEVAGPPPTWSALSKLRGLRRREQL
>NC_014666.1|WP_013428225.1|8737939_8738599_-|HNH-endonuclease
MTDELFPIPEPLVRPVIALPPHLKELIDLLPLNTPVHRRDLEAKYGRSNYARRIRKIISEYGWEIESRRQSEGANDDWYIRRSDGPVRPQRIRREVPRRSRETVYRRDDWICQICRMKTDPERGSLVPQCDHKIPADRGGDSDEENLQTLCTRCNLKKRQACGGCALASCADCPFAYPEKFDDVLILHLDREHLKRIMTTAYARNVTASAVVSDLSDLL
>NC_014666.1|WP_157735229.1|8736832_8737957_+|DNA-(cytosine-5-)-methyltransferase
MRSGHGALRAIGATKDSELVSSESKPTLIDLFCGAGGMTLGFMQAGFQPILSIDHDLPSIETHRANFPGMSICTDIRDFVDFPSADVVVGGPPCQGFSRLGKQARKERLENFLWKDYMRCVASSKPSVFVIENVPEFLKDPAFLGVSEESEKLGYKLTVSVLNAADFGVPQRRQRTIMIGSRIGPPSLPRATHQKPGDQMNLFTELPTWRTVRDAIGDLPLEPTNENLHNSRNVSKLSLERYRHVPPGGNRKDLPEDLQPDCWRYKDPRGGGSTDLMGRLEWDAPSLTIRTQFLKPEKGRYLHPAADRSITVREGARLQTFPDDFKFTGSVFQTVKQIGNAVPVELARQVALEVFQHMASNCYEWGNHPLEQVG
>NC_014666.1|WP_013428235.1|8753042_8753543_-|GNAT-family-N-acetyltransferase
MLETDRLVLRPLRLADVDAFLALHADDRVNRFVGTYTRDQALVRLETVEKQWADRGHGLFSVHLKTTGEFVGRIGPQFWDEFGEVEMAWTLRAEAWGRGYATEAAQACIDWAFEHLTENYLAAYIHPENAASHRVAQRLGFSVLRHGILFDKPVIVYALNRPTTRA
>NC_014666.1|WP_013428236.1|8753670_8754687_-|GTP-binding-protein
MGQRVPVIALTGYLGAGKTTVLNHLLRAPGARIGVVVNDFGAINVDAALITGQVDEPAAITGGCVCCVPDTDGLDDALEKLTQPRLRLDAVLVEASGVADPPALARLIQFSGVRRARPGGLVDVIDAAAYFDTVDSGGPPPARFSAASLVVINKTDRVATEVRAETVARIAARVREANPRAHLVDTTHGRVDPALVFDAATTEDPVDELPFAAAARQDPGEESHRHVHAVTVPATGPIDPGPLVDLLEDPPAGAYRLKGTVTVDTGRGPRGFVVNIVGPQIHVAARPSSDGPDGLVAIGLHLDQAAARARLEEVLRPCSGRPAAEGVRRFTRYRRLSS
>NC_014666.1|WP_041259852.1|8754765_8756124_-|replicative-DNA-helicase
MTVTDISRGGGQPLELDRTPPHDIPAEQSVLGGMLLSKDAIADVVEVLRATDFYRPAHATVFEVVGDLYGRGEPADTVSVAAELGRRELLERVGGAGYLHTLISSVPTAANAGYYAHIVAEKAVLRRLAEAGTRIVQLAYGPAHDVDALVDRAQAAVYDVTERRGTDDYAPLGDLLNPALEEIEAIAGHEGALTGVPTGFADLDELTNGLHGGQLWIVAARPAVGKSTLGLDFARAASIKHGMASVIFSLEMSRMEITMRLLSAEARVSLQNIRTGRLTDEDWARLARRMGEVAEAPLFIDDSPNLTMMEIRAKARRLRQRNDLRLIILDYLQLMSSPKRVESRQQEVSEISRSLKLLAKELEIPVVAISQLNRASEQRADKRPQVSDLRESGSLEQDADAVILLYREDTVEKESARAGEADLIIAKHRNGPTGTVTVAFQGHYSRFVDMAN
>NC_014666.1|WP_013428238.1|8756910_8757357_-|50S-ribosomal-protein-L9
MKLVLTHEVPGLGSPGDIVEVADGYGRNYLVPKQFAIVATRGVERQVDQIKRARSAREVRDLGHAQEIAEQLKALSVTLVSRAGKEGRLFGSITAGDVTDAVTRAGGPALDKRKVQLTSPIKSLGQHTVAVHLHPEVTAQVTVRVSAA
>NC_014666.1|WP_007516941.1|8757373_8757610_-|30S-ribosomal-protein-S18
MAKAAVRKPKKKVCVFCKDKTEYIDYKDTSLLRKFISDRGKIRARRVTGNCSQHQRDVAIAVKNSREMALLPYTSTAR
>NC_014666.1|WP_013428239.1|8757699_8758290_-|single-stranded-DNA-binding-protein
MAGETVITVVGNLTSDPELRFTPNGAAVASFTVASTPRTLDRATNEWKDGEALFLRCSIWRQAAEHVAESLQKGARVIVQGRLKQRTFETREGEKRTVIELDVDEIGPSLRYATAKVVRAARGGGPGGGGGFDGGGYSGGGPSGGAGGASAGGAGGGGGYRGGGQGGSSSGGGYSGGAVDDPWSQSAGGYSDEPPF
>NC_014666.1|WP_041259853.1|8758343_8758652_-|30S-ribosomal-protein-S6
MVILDPDLEERTVSPSLDQFLSVVRNGGGAVEKVDVWGRRRLAYEIRKSHEGIYAVIDLHAEPDVVAELDRQLTLNESVIRTKVIRLPEAKKPRAARRPVAA
>NC_014666.1|WP_157735231.1|8758925_8759477_-|hypothetical-protein
MSTDGDPAGPPADGAPAHEPRPAPAAPADRAGIEAGDAAPRDVGPVAPERPGGGLGAVSRRWKATSPPGAGSRRDAGPRRQFTERERAINALAYPVAGTAAAAVVVVIVVALVDPSPGRHVRGLLILLALVGLLAAACGWVRTVWHGPTDDPGADAATDGPSSPAHSAARPQGGERQIVRHVE
>NC_014666.1|WP_157735638.1|8759872_8760973_-|hypothetical-protein
MRATLPVWFASRVGVAVLSYAAARVAVEGALGRQPTFLALWDRWDVGLFTKVARYGYVSPHYADQTEVDFPAFPLAIRLVHLFTRSWLASGLIVVFLAGAVAMAAIWRLAADEDGPEAGRAAVLAAIFAPYAVFLFAGYSEALFLAFASTAWLAGRRGHWWVAGLLAAGATGTRITGIPLWCGLVVLYLVERRSAGQPVLARPAFALALPPLPVFGFLWYLHGKTGEWNAYTVAMRAGWHRWTDWPWSGWRATWHSAFPGPDGSTTFTWFWRAELLAVVLGVVVTILLLRGRRWAEATFVGTATLLMAATNYYASGVRTMLVAFPVYLLLARLAGRYPRLAPAYLWLSGPVMAAFVVAFTQGHWVD
>NC_014666.1|WP_013428243.1|8761059_8763117_-|DUF2029-domain-containing-protein
MTAADVVDATVSPSDEDPVVRGASELVGGPPGRHAALPASTWWTPLRVLLALTIVVCGLGYTQKATCRDTRNWAHEYQYTRMCYSDVVALYSQEGLSGGKTPYLDYPTEYPPLIGLTMEVVGAVSRLAPTQHPVYKTVNGQQVVDHYTMDSRSALFYDLTWVLFLGLACVTVVATALTAGRRRIWDAALFALAPTMVLHLLTNWDIIAVAFAALAIYAWSRRMPVVAGVMLGLGVCTKLYPIFFLVGLFVLCLRTGYLRTFARTAIATAATIVAIMLPTWLVAGYFVGTQKVQDGILPTFFSGGDWLSLLGGHGPDGSRNAVEQFFHLNETRVADWDSVAFALQWLSGAHDPGWFAGLHLVVVLLSGLLLAGAVVLVRYRAERARWAAGPEEPERAQGLLDAPRVQVAVAGGTWLVIVIATPLVLTAIREHGVPVHVLNWVTAVVLLMVVAAICALCWFAPRRPRLPQVLFLLVVAFLVTNKVFSPQYTLWLVPLYALARPKWRAFLVWQATEAYLLFMRFMHFIYNDTSGGRGVARGWFVGAVALRDLMLVVLAGLVVREILRPELDVVRASGLDDPAGGVLDGAADAAVGRGRAVRRDYAPSERPPSERPPAPEPSPTVPEYAETGPLPSLGRRWRRAEAVGDTGATQTGTGTSGRGGETGGDGGLSEPGALFKPRRTDPDAP

Crispr_ID: NC_014666_21

• CRISPR_ID: NC_014666_21
• CRISPR_location: 8752351-8752628
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NC_014666_21

Consensus_repeat	Method
CCAGCCGACACCGGTAACGATCTCCGCGTTCCGCGGAACGCGACCGAGCCACGAGCG	PILER-CR

spacers of NC_014666_21

>21.1|8752408|67|NC_014666|PILER-CR
AACTCACCGACTCCTGGGCCGATCTGCGCGCAGATGCGACAGATCGCCGCGTTCCCGGAACGCCCCG
>21.2|8752532|48|NC_014666|PILER-CR
TGGCGTCGCCACGGCCCAGTCCGGCGACCGCCCACGCGCTACCGTCGC

CRISPR arrays and Neighbor proteins around NC_014666_21

CRISPR arrays

The CRISPR arrays of NC_014666_21

>merge|NC_014666|21|8752351-8752628|PILER-CR
CCAGCCAACAGCGGTGACGATCTCCGCGTTCCGCGGAACGCGACCGAGCCACGAGCGAACTCACCGACTCCTGGGCCGATCTGCGCGCAGATGCGACAGATCGCCGCGTTCCCGGAACGCCCCGCCAGCCGACACCGATCACGATCTCCGCGTTCCGCGGAACGCGACCGAGCTGGCGTCGCCACGGCCCAGTCCGGCGACCGCCCACGCGCTACCGTCGCCCAGCCGACGCCGGTAACGATCTCCGCGTTCCGCGGAACGCGACCGAGCGACGAGTG

>NC_014666|21|4|8752351-8752628|PILER-CR
CCAGCCAACAGCGGTGACGATCTCCGCGTTCCGCGGAACGCGACCGAGCCACGAGCG	AACTCACCGACTCCTGGGCCGATCTGCGCGCAGATGCGACAGATCGCCGCGTTCCCGGAACGCCCCG
CCAGCCGACACCGATCACGATCTCCGCGTTCCGCGGAACGCGACCGAGCTGGCGTCG	CCACGGCCCAGTCCGGCGACCGCCCACGCGCTACCGTCGCCCAGCCGA
CGCCGGTAACGATCTCCGCGTTCCGCGGAACGCGACCGAGCGACGAGTG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_014666.1|WP_157735636.1|8744614_8745634_+|L-histidine-N(alpha)-methyltransferase	unknown	unknown	gnl|CDD|378355
NC_014666.1|WP_013428228.1|8741904_8743434_+|ergothioneine-biosynthesis-protein-EgtB	unknown	unknown	gnl|CDD|274581
NC_014666.1|WP_013428231.1|8745731_8747585_-|dihydroxy-acid-dehydratase	unknown	unknown	gnl|CDD|237104
NC_014666.1|WP_041259852.1|8754765_8756124_-|replicative-DNA-helicase	unknown	unknown	gnl|CDD|273206
NC_014666.1|WP_013428235.1|8753042_8753543_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|379112
NC_014666.1|WP_013428226.1|8738974_8739775_-|NERD-domain-containing-protein	unknown	unknown	gnl|CDD|377990
NC_014666.1|WP_041259853.1|8758343_8758652_-|30S-ribosomal-protein-S6	unknown	unknown	gnl|CDD|179034
NC_014666.1|WP_007516941.1|8757373_8757610_-|30S-ribosomal-protein-S18	unknown	unknown	gnl|CDD|178997
NC_014666.1|WP_013428229.1|8743481_8744387_+|ergothioneine-biosynthesis-protein-EgtC	unknown	unknown	gnl|CDD|132483
NC_014666.1|WP_013428239.1|8757699_8758290_-|single-stranded-DNA-binding-protein	unknown	unknown	gnl|CDD|236092
NC_014666.1|WP_013428238.1|8756910_8757357_-|50S-ribosomal-protein-L9	unknown	unknown	gnl|CDD|234659
NC_014666.1|WP_013428233.1|8750693_8751047_+|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl|CDD|367760
NC_014666.1|WP_157735231.1|8758925_8759477_-|hypothetical-protein	unknown	unknown	unknown
NC_014666.1|WP_013428225.1|8737939_8738599_-|HNH-endonuclease	unknown	unknown	gnl|CDD|366837
NC_014666.1|WP_013428236.1|8753670_8754687_-|GTP-binding-protein	unknown	unknown	gnl|CDD|223597
NC_014666.1|WP_157735229.1|8736832_8737957_+|DNA-(cytosine-5-)-methyltransferase	unknown	unknown	gnl|CDD|223348
NC_014666.1|WP_157735638.1|8759872_8760973_-|hypothetical-protein	unknown	unknown	gnl|CDD|282094
NC_014666.1|WP_013428243.1|8761059_8763117_-|DUF2029-domain-containing-protein	unknown	unknown	gnl|CDD|227937
NC_014666.1|WP_157735637.1|8747932_8750512_-|protein-kinase	unknown	unknown	gnl|CDD|270916
NC_014666.1|WP_013428234.1|8751076_8751736_+|hypothetical-protein	unknown	unknown	gnl|CDD|236090

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_014666.1|WP_157735636.1|8744614_8745634_+|L-histidine-N(alpha)-methyltransferase	gnl|CDD|378355	pfam10017, Methyltransf_33, Histidine-specific methyltransferase, SAM-dependent. The mycobacterial members of this family are expressed from part of the ergothioneine biosynthetic gene cluster. EGTD is the histidine methyltransferase that transfers three methyl groups to the alpha-amino moiety of histidine, in the first stage of the production of this histidine betaine derivative that carries a thiol group attached to the C2 atom of an imidazole ring.	1.0395e-143
NC_014666.1|WP_013428228.1|8741904_8743434_+|ergothioneine-biosynthesis-protein-EgtB	gnl|CDD|274581	TIGR03440, egtB_TIGR03440, ergothioneine biosynthesis protein EgtB. Members of this family include EgtB, and enzyme of the ergothioneine biosynthesis, as found in numerous Actinobacteria. Characterized homologs to this family include a formylglycine-generating enzyme that serves as a maturase for an aerobic sulfatase (cf. the radical SAM enzymes that serve as anaerobic sulfatase maturases). [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	1.0192e-144
NC_014666.1|WP_013428231.1|8745731_8747585_-|dihydroxy-acid-dehydratase	gnl|CDD|237104	PRK12448, PRK12448, dihydroxy-acid dehydratase; Provisional.	0
NC_014666.1|WP_041259852.1|8754765_8756124_-|replicative-DNA-helicase	gnl|CDD|273206	TIGR00665, DnaB, replicative DNA helicase. This model describes the helicase DnaB, a homohexameric protein required for DNA replication. The homohexamer can form a ring around a single strand of DNA near a replication fork. An intein of > 400 residues is found at a conserved location in DnaB of Synechocystis PCC6803, Rhodothermus marinus (both experimentally confirmed), and Mycobacterium tuberculosis. The intein removes itself by a self-splicing reaction. The seed alignment contains inteins so that the model built from the seed alignment will model a low cost at common intein insertion sites. [DNA metabolism, DNA replication, recombination, and repair].	0
NC_014666.1|WP_013428235.1|8753042_8753543_-|GNAT-family-N-acetyltransferase	gnl|CDD|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	3.53748e-34
NC_014666.1|WP_013428226.1|8738974_8739775_-|NERD-domain-containing-protein	gnl|CDD|377990	pfam08378, NERD, Nuclease-related domain. The nuclease-related domain (NERD) is found in a range of bacterial as well as archaeal and plant proteins. It has distant similarity to endonucleases (hence its name) and its predicted secondary structure is helix - sheet - sheet - sheet - sheet - weak sheet/long loop - helix - sheet - sheet. The majority of NERD-containing proteins are single-domain, but in several cases proteins containing NERD have additional domains which in 75% of cases are involved in DNA processing.	5.74007e-11
NC_014666.1|WP_041259853.1|8758343_8758652_-|30S-ribosomal-protein-S6	gnl|CDD|179034	PRK00453, rpsF, 30S ribosomal protein S6; Reviewed.	6.47438e-38
NC_014666.1|WP_007516941.1|8757373_8757610_-|30S-ribosomal-protein-S18	gnl|CDD|178997	PRK00391, rpsR, 30S ribosomal protein S18; Reviewed.	1.85905e-37
NC_014666.1|WP_013428229.1|8743481_8744387_+|ergothioneine-biosynthesis-protein-EgtC	gnl|CDD|132483	TIGR03442, TIGR03442, ergothioneine biosynthesis protein EgtC. Members of this strictly bacterial protein family show similarity to class II glutamine amidotransferases (see pfam00310). They are distinguished by appearing in a genome context with, and usually adjacent to or between, members of families TIGR03438 (an uncharacterized methyltransferase) and TIGR03440 (an uncharacterized protein). [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	4.47864e-91
NC_014666.1|WP_013428239.1|8757699_8758290_-|single-stranded-DNA-binding-protein	gnl|CDD|236092	PRK07772, PRK07772, single-stranded DNA-binding protein; Provisional.	8.3018e-91
NC_014666.1|WP_013428238.1|8756910_8757357_-|50S-ribosomal-protein-L9	gnl|CDD|234659	PRK00137, rplI, 50S ribosomal protein L9; Reviewed.	1.714e-63
NC_014666.1|WP_013428233.1|8750693_8751047_+|antibiotic-biosynthesis-monooxygenase	gnl|CDD|367760	pfam03992, ABM, Antibiotic biosynthesis monooxygenase. This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.	6.62712e-13
NC_014666.1|WP_013428225.1|8737939_8738599_-|HNH-endonuclease	gnl|CDD|366837	pfam01844, HNH, HNH endonuclease. His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.	2.58727e-08
NC_014666.1|WP_013428236.1|8753670_8754687_-|GTP-binding-protein	gnl|CDD|223597	COG0523, COG0523, Putative GTPases (G3E family) [General function prediction only].	9.4747e-55
NC_014666.1|WP_157735229.1|8736832_8737957_+|DNA-(cytosine-5-)-methyltransferase	gnl|CDD|223348	COG0270, Dcm, Site-specific DNA methylase [DNA replication, recombination, and repair].	3.51114e-79
NC_014666.1|WP_157735638.1|8759872_8760973_-|hypothetical-protein	gnl|CDD|282094	pfam04188, Mannosyl_trans2, Mannosyltransferase (PIG-V). This is a family of eukaryotic ER membrane proteins that are involved in the synthesis of glycosylphosphatidylinositol (GPI), a glycolipid that anchors many proteins to the eukaryotic cell surface. Proteins in this family are involved in transferring the second mannose in the biosynthetic pathway of GPI.	0.000367977
NC_014666.1|WP_013428243.1|8761059_8763117_-|DUF2029-domain-containing-protein	gnl|CDD|227937	COG5650, COG5650, Predicted integral membrane protein [Function unknown].	1.23314e-21
NC_014666.1|WP_157735637.1|8747932_8750512_-|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.53651e-79
NC_014666.1|WP_013428234.1|8751076_8751736_+|hypothetical-protein	gnl|CDD|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	9.18523e-06

Protein sequences

>NC_014666.1|WP_013428234.1|8751076_8751736_+|hypothetical-protein
MGEFFKQFFGFLVFSPLTAAVFGFGIWILPAVFLRDVVARLRLRFFHFFVSGYVFIAIMTIYLLAAGSRTKTGDRHHQAGPFVGMLASLALAWWLNRLLRTRFPRRNPGGTNGSGVAAGQQPGYPGAHQHGYPGPNQPGYGHPAYRPPGYGQQPGYPPHPGYPGYPAYGPPQPAPPVQPSNQPPAHPDADGIPNQPRTPGVPWVVPPPADPAPPTTPPE
>NC_014666.1|WP_013428233.1|8750693_8751047_+|antibiotic-biosynthesis-monooxygenase
MSATGPAAGGTPVTEIARFDVKPGTESDFIVAYRTVRHEIATAPGCRSIRMSRGVESPSSFVLIVEWASLEAHTEGFRGSEGFGRWRAAIGPFFAGTPSVEHVASVEASAEATAGAV
>NC_014666.1|WP_157735637.1|8747932_8750512_-|protein-kinase
MVVGDSAVGSQLVEPLDEDDPTRLGPYLLLGRLGQGGMGTVYLGRRTGVNGSGLLAEAAVQSPQDDGKTGENGTGPLVAVKMVRPDLAREPEFRERFGREATAARRVARFCTAEVLDVDVESRRPYLVTEYIEGRTLAATVRQDGPLSSAEVERLAVAVASALTAIHAAGLVHRDLKPGNIMLSPSGARVIDFGIARALDATTTFTHAGVGTPAFMAPEQALGAVVAPPADIYAWGGVLLFAATGRLPHGEGPSPVILYRAVNDEPDLSGLEPGLRQLVARAMAKDPDRRPTAQELLLHLVGARPLDGLDGPSAAVLDSAPAGDLDEALALAAEIARDFGDDTLGTHDASGPGGQNAPGRPAALDDPAAPGNLAAPGGAAAPGGQIAPGGATALGGATAADGATAPGDPTAPSDPTGPGDLMGPAGGRSTAPADQDSRSRPAAGPARGTAGGPVTPTATPSPRAVTTDPPTRDATTFVPSHLRADGDRSDEPSRRRDGEPVTGVTARRRSGRLFAGRRGAAGGTVNATPLGEPLAGHTGHVESVAFAPGGGVLASGGADGTVRRWRLAEEAPGPDVAIPLGEPLRGHEGRVLAVAYAPDGTALATAGSDHTVRVWRQPAVEATGPSARMPAIGLGHTDQVTAVAFSPLGRFLATGSLDGTARLWELDPGERDPAASGRGVVRQFGQPLGGHQGKVLAVAFSPDGGLLATAGTDHTALLWDLTATVPRPVGPPLAGHRWHVQALAFTQDGRVLVAGAGFGAVHLWDVDKPDRPYPLAQVTSRGNGQIRSVALSADGRTLAAAGGIGAAVQLWTLDDLTSPEPLGQLATGHVGTVRALAFSPTSDTLATAGDNTVRLWQPS
>NC_014666.1|WP_013428231.1|8745731_8747585_-|dihydroxy-acid-dehydratase
MPALRSRTTTHGRNMAGARALWRATGMTEDDFGKPIVAIANSFTQFVPGHVHLRDLGKLVADSVAAAGGVGREFNTIAVDDGIAMGHGGMLYSLPSREIIADSVEYMVNAHCADALVCISNCDKITPGMLLAALRLNIPTVFVSGGAMESGNAVVQNGTVRSRLDLIDAMSAAVNPDVSDADLGIIERSACPTCGSCSGMFTANSMNCLTEALGLALPGNGSTLATAAARKELFVEAGRLVVDLARRYYEKDDEGVLPRSIASAAAFRNAFAVDVAMGGSTNTVLHLLAAAVEAEVPVDLHDIDEISRRVPNLCKVAPSSTKYYMEDVHRAGGIPAILGELDRAGLLDRGVHSVHSASLREFLDRWDIRSASPAPDAVELFHAAPGGVRTVEPFSSTNRWDTLDTDAVDGCIRSAEHAYSAEGGLAVLHGNLADDGAVVKTAGVPEDQWVFAGPAVVVESQEAAVEAILGNRVKPGDVVVVRYEGPRGGPGMQEMLYPTAYLKGRGLGPKCALITDGRFSGGSSGLSIGHVSPEAAHGGTIALVRDGDRIEIDIPARRIELMVPEAELASRRAELEAGNGYRPVNRERTVSAALRAYAAMATSAATGAARDVSLLGG
>NC_014666.1|WP_157735636.1|8744614_8745634_+|L-histidine-N(alpha)-methyltransferase
MTIERHLTDAQRTAALAADVRRGLAATPKELPPTWFYDTTGSMLFGKITELPEYYQTRAERAILATHAAQLATELETAVPGGVDSLVELGSGTSEKTRTLLAALAGTGRLRRFIPFDVDAEALSRAGAAARANHPGLAVHAVVGDFRQHLGLLPIQPAGGTLVAFLGGAIGNLRPPERAALLTELRSGLDQANGSREHGGRAQALLLGTDLVKEPARLVAAYDDSAGVTAAFNRNLLTVLNRELGADFDLRGFAHVAHWDAENRWIEMRLRSVKAQTVKVTALDLTVEFAEGEEIRTEISAKFDHAMVERELAAAGWRLAQWWADPDGDFALSLAIAAA
>NC_014666.1|WP_013428229.1|8743481_8744387_+|ergothioneine-biosynthesis-protein-EgtC
MCRHLAWLGADRTLADLLLRRPSGLLQQSWAPRQQRHGRVNADGFGVGWYVPALRPQPARYRRAVPMWTDASFASFAEVVASGCVLAAVRDATVGMPIEETSTAPFTHGPLLLSHNGRVSVDVLLALLAGRPDAPPPDSRCDSALLAALVWERALAGLTLADAVAEVVTTVGAKAAAREASRAAGDAGQQPPSRLNVLVTDGRQIVATTWDDTLWYRVSSAGVLVASEPDDDAPMVRVPGGAESVSEGRASAESHPATELHPGNGTDVWVEVPNHRLLVADTRKVTVSNLISQDGYSGFTT
>NC_014666.1|WP_013428228.1|8741904_8743434_+|ergothioneine-biosynthesis-protein-EgtB
MAGSAVPAHPGPTTAEPATADEGTDLSGGLAAGGSHPAPVPAGPAGWAEALERSRRRTLTYTDLDDDLLIRQHSPLMSPLVWDLAHIGNYEELWLLRALTGADPLLPGIDDLYDAFRHPRADRPALPLLPPDQARGYIADVRSRVLDAMAALDSRSVDSRPAGWGGQRDDVVTRLLSGGFVYGMVVQHEHQHDETLLATLQLATAARVQPRPARDPVVDEGVALPAGRPVSGEVLVPAGPFTMGTSTDPWAYDNERPAHRVDVPAFWIDRLPVSNRAQLAFLDAGGYDDERLWSPAGWAWRCRERLEAPLFWRRDGAGGWLRRRFGRDEALPLDEPVQHVCWYEAEAHARWAGRRLPTETEWEKACAFDPASGRSRRFPWGDDPPTPRHANLGHRAARPAPLGAYPDGASASGVEQMIGDVWEWTSSGFTAYPGFAAFPYREYSEVFFRGPDGVERADADPDQQFRGYRVLRGGSWAADPSAARATFRNWDHPIRRQIFVGFRLARDAD
>NC_014666.1|WP_013428226.1|8738974_8739775_-|NERD-domain-containing-protein
MAEYRRRRALYVAERDDRRVRAAIIAGSAAVGAALVVVLIGISLHGAAAVLVRSGVAAALLVLVVAAVRFFRIPPEIEAWRRDAGAERRTARALDRLNRAGYTVLHDRSTADSAGNIDHLIIGASGVWVIETDAHRGPVRSSGGGVWAGKAPLRARLGLVAWTGEQVSAALLAELPEGWQLQAQTVLAFARADVPGGLALVDGVLLLPAAGVAEYVLSAGVVLRPLDVAMLVDVAQRALPAYEVAGPPPTWSALSKLRGLRRREQL
>NC_014666.1|WP_013428225.1|8737939_8738599_-|HNH-endonuclease
MTDELFPIPEPLVRPVIALPPHLKELIDLLPLNTPVHRRDLEAKYGRSNYARRIRKIISEYGWEIESRRQSEGANDDWYIRRSDGPVRPQRIRREVPRRSRETVYRRDDWICQICRMKTDPERGSLVPQCDHKIPADRGGDSDEENLQTLCTRCNLKKRQACGGCALASCADCPFAYPEKFDDVLILHLDREHLKRIMTTAYARNVTASAVVSDLSDLL
>NC_014666.1|WP_157735229.1|8736832_8737957_+|DNA-(cytosine-5-)-methyltransferase
MRSGHGALRAIGATKDSELVSSESKPTLIDLFCGAGGMTLGFMQAGFQPILSIDHDLPSIETHRANFPGMSICTDIRDFVDFPSADVVVGGPPCQGFSRLGKQARKERLENFLWKDYMRCVASSKPSVFVIENVPEFLKDPAFLGVSEESEKLGYKLTVSVLNAADFGVPQRRQRTIMIGSRIGPPSLPRATHQKPGDQMNLFTELPTWRTVRDAIGDLPLEPTNENLHNSRNVSKLSLERYRHVPPGGNRKDLPEDLQPDCWRYKDPRGGGSTDLMGRLEWDAPSLTIRTQFLKPEKGRYLHPAADRSITVREGARLQTFPDDFKFTGSVFQTVKQIGNAVPVELARQVALEVFQHMASNCYEWGNHPLEQVG
>NC_014666.1|WP_013428235.1|8753042_8753543_-|GNAT-family-N-acetyltransferase
MLETDRLVLRPLRLADVDAFLALHADDRVNRFVGTYTRDQALVRLETVEKQWADRGHGLFSVHLKTTGEFVGRIGPQFWDEFGEVEMAWTLRAEAWGRGYATEAAQACIDWAFEHLTENYLAAYIHPENAASHRVAQRLGFSVLRHGILFDKPVIVYALNRPTTRA
>NC_014666.1|WP_013428236.1|8753670_8754687_-|GTP-binding-protein
MGQRVPVIALTGYLGAGKTTVLNHLLRAPGARIGVVVNDFGAINVDAALITGQVDEPAAITGGCVCCVPDTDGLDDALEKLTQPRLRLDAVLVEASGVADPPALARLIQFSGVRRARPGGLVDVIDAAAYFDTVDSGGPPPARFSAASLVVINKTDRVATEVRAETVARIAARVREANPRAHLVDTTHGRVDPALVFDAATTEDPVDELPFAAAARQDPGEESHRHVHAVTVPATGPIDPGPLVDLLEDPPAGAYRLKGTVTVDTGRGPRGFVVNIVGPQIHVAARPSSDGPDGLVAIGLHLDQAAARARLEEVLRPCSGRPAAEGVRRFTRYRRLSS
>NC_014666.1|WP_041259852.1|8754765_8756124_-|replicative-DNA-helicase
MTVTDISRGGGQPLELDRTPPHDIPAEQSVLGGMLLSKDAIADVVEVLRATDFYRPAHATVFEVVGDLYGRGEPADTVSVAAELGRRELLERVGGAGYLHTLISSVPTAANAGYYAHIVAEKAVLRRLAEAGTRIVQLAYGPAHDVDALVDRAQAAVYDVTERRGTDDYAPLGDLLNPALEEIEAIAGHEGALTGVPTGFADLDELTNGLHGGQLWIVAARPAVGKSTLGLDFARAASIKHGMASVIFSLEMSRMEITMRLLSAEARVSLQNIRTGRLTDEDWARLARRMGEVAEAPLFIDDSPNLTMMEIRAKARRLRQRNDLRLIILDYLQLMSSPKRVESRQQEVSEISRSLKLLAKELEIPVVAISQLNRASEQRADKRPQVSDLRESGSLEQDADAVILLYREDTVEKESARAGEADLIIAKHRNGPTGTVTVAFQGHYSRFVDMAN
>NC_014666.1|WP_013428238.1|8756910_8757357_-|50S-ribosomal-protein-L9
MKLVLTHEVPGLGSPGDIVEVADGYGRNYLVPKQFAIVATRGVERQVDQIKRARSAREVRDLGHAQEIAEQLKALSVTLVSRAGKEGRLFGSITAGDVTDAVTRAGGPALDKRKVQLTSPIKSLGQHTVAVHLHPEVTAQVTVRVSAA
>NC_014666.1|WP_007516941.1|8757373_8757610_-|30S-ribosomal-protein-S18
MAKAAVRKPKKKVCVFCKDKTEYIDYKDTSLLRKFISDRGKIRARRVTGNCSQHQRDVAIAVKNSREMALLPYTSTAR
>NC_014666.1|WP_013428239.1|8757699_8758290_-|single-stranded-DNA-binding-protein
MAGETVITVVGNLTSDPELRFTPNGAAVASFTVASTPRTLDRATNEWKDGEALFLRCSIWRQAAEHVAESLQKGARVIVQGRLKQRTFETREGEKRTVIELDVDEIGPSLRYATAKVVRAARGGGPGGGGGFDGGGYSGGGPSGGAGGASAGGAGGGGGYRGGGQGGSSSGGGYSGGAVDDPWSQSAGGYSDEPPF
>NC_014666.1|WP_041259853.1|8758343_8758652_-|30S-ribosomal-protein-S6
MVILDPDLEERTVSPSLDQFLSVVRNGGGAVEKVDVWGRRRLAYEIRKSHEGIYAVIDLHAEPDVVAELDRQLTLNESVIRTKVIRLPEAKKPRAARRPVAA
>NC_014666.1|WP_157735231.1|8758925_8759477_-|hypothetical-protein
MSTDGDPAGPPADGAPAHEPRPAPAAPADRAGIEAGDAAPRDVGPVAPERPGGGLGAVSRRWKATSPPGAGSRRDAGPRRQFTERERAINALAYPVAGTAAAAVVVVIVVALVDPSPGRHVRGLLILLALVGLLAAACGWVRTVWHGPTDDPGADAATDGPSSPAHSAARPQGGERQIVRHVE
>NC_014666.1|WP_157735638.1|8759872_8760973_-|hypothetical-protein
MRATLPVWFASRVGVAVLSYAAARVAVEGALGRQPTFLALWDRWDVGLFTKVARYGYVSPHYADQTEVDFPAFPLAIRLVHLFTRSWLASGLIVVFLAGAVAMAAIWRLAADEDGPEAGRAAVLAAIFAPYAVFLFAGYSEALFLAFASTAWLAGRRGHWWVAGLLAAGATGTRITGIPLWCGLVVLYLVERRSAGQPVLARPAFALALPPLPVFGFLWYLHGKTGEWNAYTVAMRAGWHRWTDWPWSGWRATWHSAFPGPDGSTTFTWFWRAELLAVVLGVVVTILLLRGRRWAEATFVGTATLLMAATNYYASGVRTMLVAFPVYLLLARLAGRYPRLAPAYLWLSGPVMAAFVVAFTQGHWVD
>NC_014666.1|WP_013428243.1|8761059_8763117_-|DUF2029-domain-containing-protein
MTAADVVDATVSPSDEDPVVRGASELVGGPPGRHAALPASTWWTPLRVLLALTIVVCGLGYTQKATCRDTRNWAHEYQYTRMCYSDVVALYSQEGLSGGKTPYLDYPTEYPPLIGLTMEVVGAVSRLAPTQHPVYKTVNGQQVVDHYTMDSRSALFYDLTWVLFLGLACVTVVATALTAGRRRIWDAALFALAPTMVLHLLTNWDIIAVAFAALAIYAWSRRMPVVAGVMLGLGVCTKLYPIFFLVGLFVLCLRTGYLRTFARTAIATAATIVAIMLPTWLVAGYFVGTQKVQDGILPTFFSGGDWLSLLGGHGPDGSRNAVEQFFHLNETRVADWDSVAFALQWLSGAHDPGWFAGLHLVVVLLSGLLLAGAVVLVRYRAERARWAAGPEEPERAQGLLDAPRVQVAVAGGTWLVIVIATPLVLTAIREHGVPVHVLNWVTAVVLLMVVAAICALCWFAPRRPRLPQVLFLLVVAFLVTNKVFSPQYTLWLVPLYALARPKWRAFLVWQATEAYLLFMRFMHFIYNDTSGGRGVARGWFVGAVALRDLMLVVLAGLVVREILRPELDVVRASGLDDPAGGVLDGAADAAVGRGRAVRRDYAPSERPPSERPPAPEPSPTVPEYAETGPLPSLGRRWRRAEAVGDTGATQTGTGTSGRGGETGGDGGLSEPGALFKPRRTDPDAP

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_014666_14	14.4|6160295|20|NC_014666|CRT	6160295-6160314	20	NC_014666.1	6200614-6200633	1	0.95
NC_014666_19	19.1|8751770|17|NC_014666|CRISPRCasFinder	8751770-8751786	17	NC_014666.1	2225291-2225307	1	0.941
NC_014666_14	14.4|6160295|20|NC_014666|CRT	6160295-6160314	20	NC_014666.1	1429274-1429293	2	0.9
NC_014666_14	14.4|6160295|20|NC_014666|CRT	6160295-6160314	20	NC_014666.1	2465165-2465184	2	0.9
NC_014666_14	14.4|6160295|20|NC_014666|CRT	6160295-6160314	20	NC_014666.1	5627704-5627723	2	0.9
NC_014666_14	14.4|6160295|20|NC_014666|CRT	6160295-6160314	20	NC_014666.1	6345940-6345959	2	0.9
NC_014666_14	14.4|6160295|20|NC_014666|CRT	6160295-6160314	20	NC_014666.1	7903254-7903273	2	0.9
NC_014666_14	14.4|6160295|20|NC_014666|CRT	6160295-6160314	20	NC_014666.1	8721057-8721076	2	0.9
NC_014666_14	14.4|6160295|20|NC_014666|CRT	6160295-6160314	20	NC_014666.1	1196949-1196968	2	0.9
NC_014666_14	14.4|6160295|20|NC_014666|CRT	6160295-6160314	20	NC_014666.1	1946217-1946236	2	0.9
NC_014666_14	14.4|6160295|20|NC_014666|CRT	6160295-6160314	20	NC_014666.1	4761940-4761959	2	0.9
NC_014666_14	14.4|6160295|20|NC_014666|CRT	6160295-6160314	20	NC_014666.1	4863060-4863079	2	0.9
NC_014666_14	14.4|6160295|20|NC_014666|CRT	6160295-6160314	20	NC_014666.1	6313358-6313377	2	0.9
NC_014666_14	14.4|6160295|20|NC_014666|CRT	6160295-6160314	20	NC_014666.1	7778301-7778320	2	0.9

1. spacer 14.4|6160295|20|NC_014666|CRT matches to position: 6200614-6200633, mismatch: 1, identity: 0.95

acctggcccggctgctggcc	CRISPR spacer
acctggccctgctgctggcc	Protospacer
********* **********

2. spacer 19.1|8751770|17|NC_014666|CRISPRCasFinder matches to position: 2225291-2225307, mismatch: 1, identity: 0.941

cgcaccgcaacccgcgg	CRISPR spacer
cgcaccgctacccgcgg	Protospacer
******** ********

3. spacer 14.4|6160295|20|NC_014666|CRT matches to position: 1429274-1429293, mismatch: 2, identity: 0.9

acctggcccggctgctggcc	CRISPR spacer
acctggccgggctgatggcc	Protospacer
******** ***** *****

4. spacer 14.4|6160295|20|NC_014666|CRT matches to position: 2465165-2465184, mismatch: 2, identity: 0.9

acctggcccggctgctggcc	CRISPR spacer
acctggccgggctgctcgcc	Protospacer
******** ******* ***

5. spacer 14.4|6160295|20|NC_014666|CRT matches to position: 5627704-5627723, mismatch: 2, identity: 0.9

acctggcccggctgctggcc	CRISPR spacer
acctggcccgccggctggcc	Protospacer
********** * *******

6. spacer 14.4|6160295|20|NC_014666|CRT matches to position: 6345940-6345959, mismatch: 2, identity: 0.9

acctggcccggctgctggcc	CRISPR spacer
acgtcgcccggctgctggcc	Protospacer
** * ***************

7. spacer 14.4|6160295|20|NC_014666|CRT matches to position: 7903254-7903273, mismatch: 2, identity: 0.9

acctggcccggctgctggcc	CRISPR spacer
acctggcccagctgctgccc	Protospacer
*********.******* **

8. spacer 14.4|6160295|20|NC_014666|CRT matches to position: 8721057-8721076, mismatch: 2, identity: 0.9

acctggcccggctgctggcc	CRISPR spacer
acctggccctgatgctggcc	Protospacer
********* * ********

9. spacer 14.4|6160295|20|NC_014666|CRT matches to position: 1196949-1196968, mismatch: 2, identity: 0.9

acctggcccggctgctggcc	CRISPR spacer
acctggcccggctgcgcgcc	Protospacer
***************  ***

10. spacer 14.4|6160295|20|NC_014666|CRT matches to position: 1946217-1946236, mismatch: 2, identity: 0.9

acctggcccggctgctggcc	CRISPR spacer
acctcgcccgggtgctggcc	Protospacer
**** ****** ********

11. spacer 14.4|6160295|20|NC_014666|CRT matches to position: 4761940-4761959, mismatch: 2, identity: 0.9

acctggcccggctgctggcc	CRISPR spacer
accaggtccggctgctggcc	Protospacer
*** **.*************

12. spacer 14.4|6160295|20|NC_014666|CRT matches to position: 4863060-4863079, mismatch: 2, identity: 0.9

acctggcccggctgctggcc	CRISPR spacer
acctggccccggtgctggcc	Protospacer
********* * ********

13. spacer 14.4|6160295|20|NC_014666|CRT matches to position: 6313358-6313377, mismatch: 2, identity: 0.9

acctggcccggctgctggcc	CRISPR spacer
accgggcccggctgctcgcc	Protospacer
*** ************ ***

14. spacer 14.4|6160295|20|NC_014666|CRT matches to position: 7778301-7778320, mismatch: 2, identity: 0.9

acctggcccggctgctggcc	CRISPR spacer
acatggccgggctgctggcc	Protospacer
** ***** ***********

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_014666_14	14.4|6160295|20|NC_014666|CRT	6160295-6160314	20	NZ_CP043441	Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence	1471410-1471429	0	1.0
NC_014666_14	14.4|6160295|20|NC_014666|CRT	6160295-6160314	20	NC_011370	Rhizobium leguminosarum bv. trifolii WSM2304 plasmid pRLG203, complete sequence	100710-100729	1	0.95
NC_014666_14	14.4|6160295|20|NC_014666|CRT	6160295-6160314	20	NZ_CP040819	Paraoceanicella profunda strain D4M1 plasmid pD4M1A, complete sequence	545154-545173	1	0.95
NC_014666_14	14.4|6160295|20|NC_014666|CRT	6160295-6160314	20	NC_017966	Tistrella mobilis KA081020-065 plasmid pTM2, complete sequence	241632-241651	1	0.95
NC_014666_14	14.1|6160169|23|NC_014666|CRT	6160169-6160191	23	NZ_CP020900	Rhizobium phaseoli Brasil 5 strain Bra5 plasmid pRphaBra5d, complete sequence	1115974-1115996	2	0.913
NC_014666_14	14.1|6160169|23|NC_014666|CRT	6160169-6160191	23	MT639641	Microbacterium phage Phinky, complete genome	44752-44774	2	0.913
NC_014666_14	14.2|6160211|23|NC_014666|CRT	6160211-6160233	23	NZ_LR134465	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 23, complete sequence	346296-346318	2	0.913
NC_014666_14	14.2|6160211|23|NC_014666|CRT	6160211-6160233	23	NZ_LR134465	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 23, complete sequence	369406-369428	2	0.913
NC_014666_14	14.2|6160211|23|NC_014666|CRT	6160211-6160233	23	NZ_CP025613	Niveispirillum cyanobacteriorum strain TH16 plasmid unnamed1, complete sequence	581810-581832	2	0.913
NC_014666_14	14.3|6160253|23|NC_014666|CRT	6160253-6160275	23	NZ_CP016082	Streptomyces sp. SAT1 plasmid unnamed2, complete sequence	284832-284854	2	0.913
NC_014666_14	14.3|6160253|23|NC_014666|CRT	6160253-6160275	23	NZ_CP032685	Rhizobium sp. CCGE531 plasmid pRCCGE531d, complete sequence	702471-702493	2	0.913
NC_014666_14	14.3|6160253|23|NC_014666|CRT	6160253-6160275	23	NC_009427	Novosphingobium aromaticivorans DSM 12444 plasmid pNL2, complete sequence	316395-316417	2	0.913
NC_014666_14	14.3|6160253|23|NC_014666|CRT	6160253-6160275	23	NZ_CP032690	Rhizobium sp. CCGE532 plasmid pRCCGE532d, complete sequence	702020-702042	2	0.913
NC_014666_14	14.3|6160253|23|NC_014666|CRT	6160253-6160275	23	NZ_CP029357	Azospirillum sp. CFH 70021 plasmid unnamed2	542843-542865	2	0.913
NC_014666_14	14.3|6160253|23|NC_014666|CRT	6160253-6160275	23	NZ_CP023408	Streptomyces fungicidicus strain TXX3120 plasmid p1, complete sequence	35586-35608	2	0.913
NC_014666_14	14.1|6160169|23|NC_014666|CRT	6160169-6160191	23	NZ_CP032324	Azospirillum brasilense strain MTCC4035 plasmid p3, complete sequence	308288-308310	3	0.87
NC_014666_14	14.1|6160169|23|NC_014666|CRT	6160169-6160191	23	NZ_CP007797	Azospirillum brasilense strain Az39 plasmid AbAZ39_p4, complete sequence	458221-458243	3	0.87
NC_014666_14	14.1|6160169|23|NC_014666|CRT	6160169-6160191	23	NZ_CP039640	Azospirillum sp. TSH100 plasmid p1, complete sequence	233608-233630	3	0.87
NC_014666_14	14.1|6160169|23|NC_014666|CRT	6160169-6160191	23	NZ_CP017076	Novosphingobium resinovorum strain SA1 plasmid pSA1, complete sequence	664731-664753	3	0.87
NC_014666_14	14.1|6160169|23|NC_014666|CRT	6160169-6160191	23	NZ_CP039697	Novosphingobium sp. ABRDHK2 plasmid pABRDHK22, complete sequence	66441-66463	3	0.87
NC_014666_14	14.2|6160211|23|NC_014666|CRT	6160211-6160233	23	NZ_CP017076	Novosphingobium resinovorum strain SA1 plasmid pSA1, complete sequence	18293-18315	3	0.87
NC_014666_14	14.2|6160211|23|NC_014666|CRT	6160211-6160233	23	NC_019957	Mycobacterium sp. JS623 plasmid pMYCSM01, complete sequence	304943-304965	3	0.87
NC_014666_14	14.2|6160211|23|NC_014666|CRT	6160211-6160233	23	MF140427	Arthrobacter phage Shrooms, complete genome	10337-10359	3	0.87
NC_014666_14	14.3|6160253|23|NC_014666|CRT	6160253-6160275	23	NZ_CP048428	Rhizobium daejeonense strain KACC 13094 plasmid unnamed4, complete sequence	82399-82421	3	0.87
NC_014666_14	14.3|6160253|23|NC_014666|CRT	6160253-6160275	23	NC_017966	Tistrella mobilis KA081020-065 plasmid pTM2, complete sequence	588806-588828	3	0.87
NC_014666_14	14.3|6160253|23|NC_014666|CRT	6160253-6160275	23	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	714224-714246	4	0.826
NC_014666_14	14.3|6160253|23|NC_014666|CRT	6160253-6160275	23	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	1098856-1098878	4	0.826
NC_014666_19	19.2|8751812|26|NC_014666|CRISPRCasFinder	8751812-8751837	26	NC_008826	Methylibium petroleiphilum PM1 plasmid RPME01, complete sequence	507530-507555	4	0.846
NC_014666_19	19.2|8751812|26|NC_014666|CRISPRCasFinder	8751812-8751837	26	NZ_CP038031	Rhodococcus ruber strain R1 plasmid unnamed1, complete sequence	34012-34037	4	0.846
NC_014666_19	19.2|8751812|26|NC_014666|CRISPRCasFinder	8751812-8751837	26	NZ_CP022367	Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence	1583579-1583604	5	0.808
NC_014666_19	19.2|8751812|26|NC_014666|CRISPRCasFinder	8751812-8751837	26	NZ_CP023440	Thauera sp. K11 plasmid pTX1, complete sequence	20432-20457	5	0.808
NC_014666_3	3.1|1685575|35|NC_014666|CRISPRCasFinder	1685575-1685609	35	NZ_CP020371	Candidatus Thiodictyon syntrophicum strain Cad16T plasmid pTs417, complete sequence	39293-39327	6	0.829
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MF141539	Mycobacterium phage MyraDee, complete genome	10755-10784	6	0.8
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	NZ_CP021368	Acidovorax carolinensis strain P4 plasmid pACP4.2, complete sequence	53162-53191	6	0.8
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	NZ_CP021364	Acidovorax carolinensis strain P3 plasmid pACP3.2, complete sequence	72238-72267	6	0.8
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	NZ_CP039965	Pseudorhodobacter sp. S12M18 plasmid unnamed1, complete sequence	81950-81979	6	0.8
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	NZ_CP054618	Azospirillum oryzae strain KACC 14407 plasmid unnamed4, complete sequence	360507-360536	6	0.8
NC_014666_10	10.1|3247606|30|NC_014666|CRISPRCasFinder	3247606-3247635	30	NZ_CP032181	Citrobacter freundii strain AR_0116 plasmid unnamed3, complete sequence	832-861	6	0.8
NC_014666_11	11.1|3547214|37|NC_014666|CRISPRCasFinder	3547214-3547250	37	MT639643	Microbacterium phage FreddieHg, complete genome	8315-8351	6	0.838
NC_014666_3	3.1|1685575|35|NC_014666|CRISPRCasFinder	1685575-1685609	35	NZ_CP051472	Rhodobacter sphaeroides strain CH10 plasmid pRspCH10C, complete sequence	90145-90179	7	0.8
NC_014666_3	3.1|1685575|35|NC_014666|CRISPRCasFinder	1685575-1685609	35	NZ_CP012965	Rhodobacter sphaeroides strain MBTLJ-8 plasmid unnamed, complete sequence	89591-89625	7	0.8
NC_014666_3	3.1|1685575|35|NC_014666|CRISPRCasFinder	1685575-1685609	35	CP047035	Rhodobacter sphaeroides strain DSM 158 plasmid pC, complete sequence	89738-89772	7	0.8
NC_014666_3	3.1|1685575|35|NC_014666|CRISPRCasFinder	1685575-1685609	35	NZ_CP047041	Rhodobacter sphaeroides strain 2.4.1 substr. H2 plasmid pC, complete sequence	89666-89700	7	0.8
NC_014666_3	3.1|1685575|35|NC_014666|CRISPRCasFinder	1685575-1685609	35	NZ_CP015214	Rhodobacter sphaeroides strain MBTLJ-13 plasmid c, complete sequence	104932-104966	7	0.8
NC_014666_3	3.1|1685575|35|NC_014666|CRISPRCasFinder	1685575-1685609	35	NZ_CP030275	Rhodobacter sphaeroides 2.4.1 plasmid pC, complete sequence	97220-97254	7	0.8
NC_014666_3	3.1|1685575|35|NC_014666|CRISPRCasFinder	1685575-1685609	35	NZ_CP015292	Rhodobacter sphaeroides strain MBTLJ-20 plasmid d, complete sequence	41758-41792	7	0.8
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	CP000663	Rhodobacter sphaeroides ATCC 17025 plasmid pRSPA02, complete sequence	65960-65989	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MH590593	Mycobacterium phage Rabinovish, complete genome	96811-96840	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	KX781992	Mycobacterium phage Gabriel, complete genome	95643-95672	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MH697579	Mycobacterium phage Cane17, complete genome	97847-97876	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK112554	Mycobacterium phage TinyTim, complete genome	96022-96051	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359314	Mycobacterium phage Ewok, complete genome	96966-96995	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359337	Mycobacterium phage Flabslab, complete genome	94934-94963	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MN234193	Mycobacterium phage Kboogie, complete genome	96312-96341	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK450432	Mycobacterium phage ValleyTerrace, complete genome	95626-95655	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MH051261	Mycobacterium phage Tyke, complete genome	97492-97521	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MH779502	Mycobacterium phage FudgeTart, complete genome	96113-96142	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359365	Mycobacterium phage Loanshark, complete genome	96496-96525	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359311	Mycobacterium phage SmallFry, complete genome	95916-95945	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359364	Mycobacterium phage ChickenPhender, complete genome	96077-96106	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359303	Mycobacterium phage Shnickers, complete genome	95720-95749	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MH697586	Mycobacterium phage InigoMontoya, complete genome	96290-96319	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK112549	Mycobacterium phage Morizzled23, complete genome	95784-95813	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK112541	Mycobacterium phage Jessibeth14, complete genome	97155-97184	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359347	Mycobacterium phage Ading, complete genome	97210-97239	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK450425	Mycobacterium phage Shelob, complete genome	97887-97916	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	NC_023714	Mycobacterium phage LinStu, complete genome	96680-96709	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359358	Mycobacterium phage Essence, complete genome	95904-95933	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	KJ595575	Mycobacterium phage Willis, complete genome	96273-96302	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MG812493	Mycobacterium phage NuevoMundo, complete genome	99000-99029	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359339	Mycobacterium phage Naija, complete genome	96329-96358	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359333	Mycobacterium phage JustHall, complete genome	96214-96243	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	KT321476	Mycobacterium phage Zeenon, complete genome	96672-96701	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MN428065	Mycobacterium phage Cactojaque, complete genome	95950-95979	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359306	Mycobacterium phage Norm, complete genome	97070-97099	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MN735434	Mycobacterium phage Mangeria, complete genome	97418-97447	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	JN699625	Mycobacterium phage Wally, complete genome	95842-95871	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	EU826471	Mycobacterium phage Cali, complete genome	96989-97018	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	KX721255	Mycobacterium phage Yucca, complete genome	96586-96615	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359366	Mycobacterium phage Basquiat, complete genome	95930-95959	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359346	Mycobacterium phage NoodleTree, complete genome	96811-96840	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	JN699013	Mycobacterium phage Pio, complete genome	99737-99766	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359361	Mycobacterium phage Darko, complete genome	96350-96379	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	NC_023725	Mycobacterium phage Nappy, complete genome	97452-97481	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359348	Mycobacterium phage Rahel, complete genome	96547-96576	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MH779498	Mycobacterium phage Bread, complete genome	96038-96067	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK450427	Mycobacterium phage Adlitam, complete genome	96198-96227	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MG812494	Mycobacterium phage Pier, complete genome	98542-98571	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	GQ303262	Mycobacterium phage LRRHood, complete genome	96084-96113	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MT818423	Mycobacterium phage Janiyra, complete genome	97307-97336	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MH316567	Mycobacterium phage ParkTD, complete genome	96374-96403	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	AY129337	Mycobacteriophage Bxz1, complete genome	99081-99110	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MH051260	Mycobacterium phage InterFolia, complete genome	98373-98402	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	KX721256	Mycobacterium phage Erdmann, complete genome	97046-97075	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359328	Mycobacterium phage EmmaElysia, complete genome	96623-96652	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	KM881426	Mycobacterium phage ZygoTaiga	97293-97322	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359335	Mycobacterium phage Patter, complete genome	95643-95672	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MT889395	Mycobacterium phage Shifa, complete genome	95924-95953	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	EU826467	Mycobacterium phage Rizal, complete genome	94814-94843	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MT723944	Mycobacterium phage ChaylaJr, complete genome	95798-95827	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	KR080196	Mycobacterium phage Momo, complete genome	95626-95655	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MH910040	Mycobacterium phage Sauce, complete genome	95333-95362	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MF919495	Mycobacterium phage Bigswole, complete genome	98654-98683	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359318	Mycobacterium phage Specks, complete genome	98123-98152	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	KF024734	Mycobacterium phage Shrimp, complete genome	97390-97419	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK112548	Mycobacterium phage McWolfish, complete genome	96393-96422	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359308	Mycobacterium phage Shaqnato, complete genome	94779-94808	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK112545	Mycobacterium phage Khaleesi, complete genome	96622-96651	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MH825697	Mycobacterium phage Bangla1971, complete genome	96016-96045	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359338	Mycobacterium phage Amataga, complete genome	95626-95655	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359350	Mycobacterium phage Nidhogg, complete genome	96904-96933	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MT723945	Mycobacterium phage Quasimodo, complete genome	97747-97776	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359342	Mycobacterium phage ShiaLabeouf, complete genome	95758-95787	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MH316561	Mycobacterium phage Derek, complete genome	96678-96707	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK112533	Mycobacterium phage Bonray, complete genome	97480-97509	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK450422	Mycobacterium phage RoMag, complete genome	96858-96887	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359327	Mycobacterium phage EmToTheThree, complete genome	97572-97601	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MH727543	Mycobacterium phage CharlieB, complete genome	95872-95901	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	JF704116	Mycobacterium phage Drazdys, complete genome	96693-96722	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359336	Mycobacterium phage Chargie21, complete genome	95930-95959	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359355	Mycobacterium phage Sprinklers, complete genome	95560-95589	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK112534	Mycobacterium phage Burrough, complete genome	97883-97912	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MF919499	Mycobacterium phage Daffodil, complete genome	96377-96406	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359334	Mycobacterium phage Delilah, complete genome	96495-96524	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	NC_023696	Mycobacterium phage Dandelion, complete genome	100472-100501	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MN276192	Mycobacterium phage Trinitium, complete genome	96252-96281	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359324	Mycobacterium phage Tortoise16, complete genome	96559-96588	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MH825713	Mycobacterium phage Zalkecks, complete genome	96102-96131	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359349	Mycobacterium phage FoxtrotP1, complete genome	97547-97576	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	JF704096	Mycobacterium phage Ghost, complete sequence	96329-96358	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MN062707	Mycobacterium phage Grungle, complete genome	93932-93961	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359344	Mycobacterium phage Napoleon13, complete genome	95589-95618	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MH727558	Mycobacterium phage Salacia, complete genome	96953-96982	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359363	Mycobacterium phage Fludd, complete genome	96885-96914	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	KX831080	Mycobacterium phage Lukilu, complete genome	97094-97123	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359329	Mycobacterium phage Kamryn, complete genome	97436-97465	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	JQ911768	Mycobacterium phage Ava3, complete genome	95809-95838	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	NC_004687	Mycobacterium phage Bxz1, complete genome	99081-99110	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	NC_011270	Mycobacterium phage Spud, complete genome	96492-96521	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MN183280	Mycobacteriophage LolaVinca, complete genome	97905-97934	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359345	Mycobacterium phage QBert, complete genome	95567-95596	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	GQ303260	Mycobacterium phage ET08, complete genome	95472-95501	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MH744422	Mycobacterium phage Roots515, complete genome	98167-98196	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359321	Mycobacterium phage Phusco, complete genome	95953-95982	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359362	Mycobacterium phage Atlantean, complete genome	95626-95655	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	EU826469	Mycobacterium phage ScottMcG, complete genome	95390-95419	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK310143	Mycobacterium phage Dietrick, complete genome	95100-95129	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK450429	Mycobacterium phage Bipolarisk, complete genome	96077-96106	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MH051266	Mycobacterium phage MikeLiesIn, complete genome	97260-97289	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	NC_029044	Mycobacterium phage Breeniome, complete genome	95669-95698	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MH669008	Mycobacterium phage Megamind, complete genome	96124-96153	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK878897	Mycobacterium phage Blackbrain, complete genome	95975-96004	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK450434	Mycobacterium phage DrPhinkDaddy, complete genome	97156-97185	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359359	Mycobacterium phage Colt, complete genome	97512-97541	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MF919527	Mycobacterium phage Phox, complete genome	97290-97319	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MT818416	Mycobacterium phage BackyardAgain, complete genome	95104-95133	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359330	Mycobacterium phage Iota, complete genome	95963-95992	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	KT365398	Mycobacterium phage DTDevon, complete genome	98150-98179	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	KX369583	Mycobacterium phage Littleton, complete genome	96786-96815	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MF919494	Mycobacterium phage BeanWater, complete genome	95670-95699	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	NC_028869	Mycobacterium phage HyRo, complete genome	95955-95984	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	KT365400	Mycobacterium phage ErnieJ, complete genome	95352-95381	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	KC691257	Mycobacterium phage Astraea, complete genome	95717-95746	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MG872839	Mycobacterium phage LifeSavor, complete genome	96535-96564	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	KC748968	Mycobacterium phage Gizmo, complete genome	97971-98000	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	KC748970	Mycobacterium phage ArcherS7, complete genome	96656-96685	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359353	Mycobacterium phage BadAgartude, complete genome	96109-96138	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MH697590	Mycobacterium phage Phlegm, complete genome	96329-96358	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359317	Mycobacterium phage FrayBell, complete genome	96670-96699	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MT553335	Mycobacterium phage Ronan, complete genome	94317-94346	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MN428066	Mycobacterium phage JPickles, complete genome	94758-94787	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359305	Mycobacterium phage Teardrop, complete genome	95318-95347	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	DQ398053	Mycobacteriophage Catera, complete genome	95070-95099	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MF919513	Mycobacterium phage Koguma, complete genome	94228-94257	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	JN699626	Mycobacterium phage MoMoMixon, complete genome	95888-95917	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	NC_028986	Mycobacterium phage Alice, complete sequence	94947-94976	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK450424	Mycobacterium phage Melpomini, complete genome	94600-94629	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	JN204348	Mycobacterium phage Sebata, complete genome	97857-97886	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MN183285	Mycobacterium phage YoungMoneyMata, complete genome	96617-96646	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK450423	Mycobacterium phage Stubby, complete genome	94776-94805	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MF919493	Mycobacterium phage Audrick, complete genome	96308-96337	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	NC_008207	Mycobacterium phage Catera, complete genome	95070-95099	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	JN624850	Mycobacterium phage Pleione, complete genome	96853-96882	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	KX752698	Mycobacterium phage Tonenili, complete genome	100770-100799	7	0.767
NC_014666_5	5.1|1888853|30|NC_014666|PILER-CR	1888853-1888882	30	MK359326	Mycobacterium phage Pivoine, complete genome	96329-96358	7	0.767
NC_014666_10	10.1|3247606|30|NC_014666|CRISPRCasFinder	3247606-3247635	30	NC_010510	Methylobacterium radiotolerans JCM 2831 plasmid pMRAD01, complete sequence	554049-554078	7	0.767
NC_014666_3	3.1|1685575|35|NC_014666|CRISPRCasFinder	1685575-1685609	35	NZ_AP014705	Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence	665615-665649	8	0.771
NC_014666_3	3.1|1685575|35|NC_014666|CRISPRCasFinder	1685575-1685609	35	MK310226	Halobacterium virus ChaoS9, complete genome	40354-40388	9	0.743
NC_014666_3	3.1|1685575|35|NC_014666|CRISPRCasFinder	1685575-1685609	35	NC_017957	Tistrella mobilis KA081020-065 plasmid pTM1, complete sequence	106971-107005	9	0.743
NC_014666_11	11.1|3547214|37|NC_014666|CRISPRCasFinder	3547214-3547250	37	MT818420	Microbacterium phage Gilda, complete genome	9097-9133	9	0.757
NC_014666_11	11.1|3547214|37|NC_014666|CRISPRCasFinder	3547214-3547250	37	MK737941	Microbacterium phage Rachella, complete genome	9102-9138	9	0.757
NC_014666_11	11.1|3547214|37|NC_014666|CRISPRCasFinder	3547214-3547250	37	MF042361	Pseudomonas phage Skulduggery, complete genome	8237-8273	9	0.757
NC_014666_11	11.1|3547214|37|NC_014666|CRISPRCasFinder	3547214-3547250	37	MT522001	Microbacterium phage Karate, complete genome	8521-8557	9	0.757
NC_014666_11	11.1|3547214|37|NC_014666|CRISPRCasFinder	3547214-3547250	37	NC_047986	Microbacterium phage Krampus, complete genome	9103-9139	9	0.757
NC_014666_11	11.1|3547214|37|NC_014666|CRISPRCasFinder	3547214-3547250	37	MH271292	Microbacterium phage AnnaSerena, complete genome	9105-9141	9	0.757
NC_014666_11	11.1|3547214|37|NC_014666|CRISPRCasFinder	3547214-3547250	37	MT522003	Microbacterium phage Rie18, complete genome	8456-8492	9	0.757
NC_014666_3	3.1|1685575|35|NC_014666|CRISPRCasFinder	1685575-1685609	35	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	1117082-1117116	10	0.714
NC_014666_3	3.2|1685638|35|NC_014666|CRISPRCasFinder	1685638-1685672	35	NZ_CP034185	Deinococcus sp. S14-83 strain S14-83T plasmid unnamed1, complete sequence	17973-18007	10	0.714
NC_014666_3	3.2|1685638|35|NC_014666|CRISPRCasFinder	1685638-1685672	35	MN184886	Erwinia phage pEp_SNUABM_08, complete genome	27852-27886	10	0.714
NC_014666_11	11.1|3547214|37|NC_014666|CRISPRCasFinder	3547214-3547250	37	NC_007762	Rhizobium etli CFN 42 plasmid p42a, complete sequence	181440-181476	10	0.73
NC_014666_11	11.1|3547214|37|NC_014666|CRISPRCasFinder	3547214-3547250	37	MH444512	Bifidobacterium phage Willi, complete genome	33507-33543	11	0.703
NC_014666_11	11.1|3547214|37|NC_014666|CRISPRCasFinder	3547214-3547250	37	MK932884	Bifidobacterium phage PMBT6, complete genome	33507-33543	11	0.703
NC_014666_11	11.1|3547214|37|NC_014666|CRISPRCasFinder	3547214-3547250	37	NZ_CP011515	Mitsuaria sp. 7 plasmid, complete sequence	8287-8323	13	0.649

1. spacer 14.4|6160295|20|NC_014666|CRT matches to NZ_CP043441 (Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence) position: , mismatch: 0, identity: 1.0

acctggcccggctgctggcc	CRISPR spacer
acctggcccggctgctggcc	Protospacer
********************

2. spacer 14.4|6160295|20|NC_014666|CRT matches to NC_011370 (Rhizobium leguminosarum bv. trifolii WSM2304 plasmid pRLG203, complete sequence) position: , mismatch: 1, identity: 0.95

acctggcccggctgctggcc	CRISPR spacer
acctggcccggctgctggcg	Protospacer
******************* 

3. spacer 14.4|6160295|20|NC_014666|CRT matches to NZ_CP040819 (Paraoceanicella profunda strain D4M1 plasmid pD4M1A, complete sequence) position: , mismatch: 1, identity: 0.95

acctggcccggctgctggcc	CRISPR spacer
ccctggcccggctgctggcc	Protospacer
 *******************

4. spacer 14.4|6160295|20|NC_014666|CRT matches to NC_017966 (Tistrella mobilis KA081020-065 plasmid pTM2, complete sequence) position: , mismatch: 1, identity: 0.95

acctggcccggctgctggcc	CRISPR spacer
ccctggcccggctgctggcc	Protospacer
 *******************

5. spacer 14.1|6160169|23|NC_014666|CRT matches to NZ_CP020900 (Rhizobium phaseoli Brasil 5 strain Bra5 plasmid pRphaBra5d, complete sequence) position: , mismatch: 2, identity: 0.913

tgctgaccctgctgcggcgggta	CRISPR spacer
tgctgagcctgctgcggcgggtg	Protospacer
****** ***************.

6. spacer 14.1|6160169|23|NC_014666|CRT matches to MT639641 (Microbacterium phage Phinky, complete genome) position: , mismatch: 2, identity: 0.913

tgctgaccctgctgcggcgggta	CRISPR spacer
tgctgaccctgctgcggagcgta	Protospacer
***************** * ***

7. spacer 14.2|6160211|23|NC_014666|CRT matches to NZ_LR134465 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 23, complete sequence) position: , mismatch: 2, identity: 0.913

tgctggccctgctgcggcgggta	CRISPR spacer
tgctggacctgctgcggcgggtc	Protospacer
****** *************** 

8. spacer 14.2|6160211|23|NC_014666|CRT matches to NZ_LR134465 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 23, complete sequence) position: , mismatch: 2, identity: 0.913

tgctggccctgctgcggcgggta	CRISPR spacer
tgcaggccctgcggcggcgggta	Protospacer
*** ******** **********

9. spacer 14.2|6160211|23|NC_014666|CRT matches to NZ_CP025613 (Niveispirillum cyanobacteriorum strain TH16 plasmid unnamed1, complete sequence) position: , mismatch: 2, identity: 0.913

tgctggccctgctgcggcgggta	CRISPR spacer
tgctggccatgctgcggcgggaa	Protospacer
******** ************ *

10. spacer 14.3|6160253|23|NC_014666|CRT matches to NZ_CP016082 (Streptomyces sp. SAT1 plasmid unnamed2, complete sequence) position: , mismatch: 2, identity: 0.913

gggtcgccgccctgcggctgccc	CRISPR spacer
tggccgccgccctgcggctgccc	Protospacer
 **.*******************

11. spacer 14.3|6160253|23|NC_014666|CRT matches to NZ_CP032685 (Rhizobium sp. CCGE531 plasmid pRCCGE531d, complete sequence) position: , mismatch: 2, identity: 0.913

gggtcgccgccctgcggctgccc	CRISPR spacer
ggctcgccgcccagcggctgccc	Protospacer
** ********* **********

12. spacer 14.3|6160253|23|NC_014666|CRT matches to NC_009427 (Novosphingobium aromaticivorans DSM 12444 plasmid pNL2, complete sequence) position: , mismatch: 2, identity: 0.913

gggtcgccgccctgcggctgccc	CRISPR spacer
gggtcgacgccctgcggctgcac	Protospacer
****** ************** *

13. spacer 14.3|6160253|23|NC_014666|CRT matches to NZ_CP032690 (Rhizobium sp. CCGE532 plasmid pRCCGE532d, complete sequence) position: , mismatch: 2, identity: 0.913

gggtcgccgccctgcggctgccc	CRISPR spacer
ggctcgccgcccagcggctgccc	Protospacer
** ********* **********

14. spacer 14.3|6160253|23|NC_014666|CRT matches to NZ_CP029357 (Azospirillum sp. CFH 70021 plasmid unnamed2) position: , mismatch: 2, identity: 0.913

gggtcgccgccctgcggctgccc	CRISPR spacer
ggctcgccaccctgcggctgccc	Protospacer
** *****.**************

15. spacer 14.3|6160253|23|NC_014666|CRT matches to NZ_CP023408 (Streptomyces fungicidicus strain TXX3120 plasmid p1, complete sequence) position: , mismatch: 2, identity: 0.913

gggtcgccgccctgcggctgccc	CRISPR spacer
gggtcgccgggctgcggctgccc	Protospacer
*********  ************

16. spacer 14.1|6160169|23|NC_014666|CRT matches to NZ_CP032324 (Azospirillum brasilense strain MTCC4035 plasmid p3, complete sequence) position: , mismatch: 3, identity: 0.87

tgctgaccctgctgcggcgggta	CRISPR spacer
cgctgaccctgctgcggcgggcg	Protospacer
.********************..

17. spacer 14.1|6160169|23|NC_014666|CRT matches to NZ_CP007797 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p4, complete sequence) position: , mismatch: 3, identity: 0.87

tgctgaccctgctgcggcgggta	CRISPR spacer
cgctgaccctgctgcggcgggcg	Protospacer
.********************..

18. spacer 14.1|6160169|23|NC_014666|CRT matches to NZ_CP039640 (Azospirillum sp. TSH100 plasmid p1, complete sequence) position: , mismatch: 3, identity: 0.87

tgctgaccctgctgcggcgggta	CRISPR spacer
cgctgacccggctgcggcgggtg	Protospacer
.******** ************.

19. spacer 14.1|6160169|23|NC_014666|CRT matches to NZ_CP017076 (Novosphingobium resinovorum strain SA1 plasmid pSA1, complete sequence) position: , mismatch: 3, identity: 0.87

tgctgaccctgctgcggcgggta	CRISPR spacer
tgctgaccctgctgcggccgggc	Protospacer
****************** **  

20. spacer 14.1|6160169|23|NC_014666|CRT matches to NZ_CP039697 (Novosphingobium sp. ABRDHK2 plasmid pABRDHK22, complete sequence) position: , mismatch: 3, identity: 0.87

tgctgaccctgctgcggcgggta	CRISPR spacer
tgctgatcctgctgcggcgggag	Protospacer
******.************** .

21. spacer 14.2|6160211|23|NC_014666|CRT matches to NZ_CP017076 (Novosphingobium resinovorum strain SA1 plasmid pSA1, complete sequence) position: , mismatch: 3, identity: 0.87

tgctggccctgctgcggcgggta	CRISPR spacer
tgctggccctgctccggcgggac	Protospacer
************* *******  

22. spacer 14.2|6160211|23|NC_014666|CRT matches to NC_019957 (Mycobacterium sp. JS623 plasmid pMYCSM01, complete sequence) position: , mismatch: 3, identity: 0.87

tgctggccctgctgcggcgggta	CRISPR spacer
ggctggccctgccgcggcgggtg	Protospacer
 ***********.*********.

23. spacer 14.2|6160211|23|NC_014666|CRT matches to MF140427 (Arthrobacter phage Shrooms, complete genome) position: , mismatch: 3, identity: 0.87

tgctggccctgctgcggcgggta	CRISPR spacer
tgctggccctgctgcggctgggc	Protospacer
****************** **  

24. spacer 14.3|6160253|23|NC_014666|CRT matches to NZ_CP048428 (Rhizobium daejeonense strain KACC 13094 plasmid unnamed4, complete sequence) position: , mismatch: 3, identity: 0.87

gggtcgccgccctgcggctgccc	CRISPR spacer
tggtcgccgccctgctgctgcca	Protospacer
 ************** ****** 

25. spacer 14.3|6160253|23|NC_014666|CRT matches to NC_017966 (Tistrella mobilis KA081020-065 plasmid pTM2, complete sequence) position: , mismatch: 3, identity: 0.87

gggtcgccgccctgcggctgccc	CRISPR spacer
gggtcgccgccctgcgggtgctg	Protospacer
***************** ***. 

26. spacer 14.3|6160253|23|NC_014666|CRT matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 4, identity: 0.826

gggtcgccgccctgcggctgccc	CRISPR spacer
tcaccgccgccctgcggctgccc	Protospacer
  ..*******************

27. spacer 14.3|6160253|23|NC_014666|CRT matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 4, identity: 0.826

gggtcgccgccctgcggctgccc	CRISPR spacer
tcaccgccgccctgcggctgccc	Protospacer
  ..*******************

28. spacer 19.2|8751812|26|NC_014666|CRISPRCasFinder matches to NC_008826 (Methylibium petroleiphilum PM1 plasmid RPME01, complete sequence) position: , mismatch: 4, identity: 0.846

cgcaccgtcccgcggaacgcgggcgg	CRISPR spacer
cgaaccgtcccgcggatcgcgggtga	Protospacer
** ************* ******.*.

29. spacer 19.2|8751812|26|NC_014666|CRISPRCasFinder matches to NZ_CP038031 (Rhodococcus ruber strain R1 plasmid unnamed1, complete sequence) position: , mismatch: 4, identity: 0.846

cgcaccgtcccgcggaacgcgggcgg	CRISPR spacer
cgcaccgtcccgcggaccgcgcccga	Protospacer
**************** ****  **.

30. spacer 19.2|8751812|26|NC_014666|CRISPRCasFinder matches to NZ_CP022367 (Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence) position: , mismatch: 5, identity: 0.808

cgcaccgtcccgcggaacgcgggcgg	CRISPR spacer
ccttgcgtcccgcggagcgcgggcgg	Protospacer
* .  ***********.*********

31. spacer 19.2|8751812|26|NC_014666|CRISPRCasFinder matches to NZ_CP023440 (Thauera sp. K11 plasmid pTX1, complete sequence) position: , mismatch: 5, identity: 0.808

cgcaccgtcccgcggaacgcgggcgg	CRISPR spacer
cgcatcgccccgcggaacgcgggaca	Protospacer
****.**.***************  .

32. spacer 3.1|1685575|35|NC_014666|CRISPRCasFinder matches to NZ_CP020371 (Candidatus Thiodictyon syntrophicum strain Cad16T plasmid pTs417, complete sequence) position: , mismatch: 6, identity: 0.829

ggatcgttc-ggccgtcgaagtcggtctcggcgacg	CRISPR spacer
-gataatgcaggccgtcgaaggcggtctgggcgacg	Protospacer
 *** .* * *********** ****** *******

33. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MF141539 (Mycobacterium phage MyraDee, complete genome) position: , mismatch: 6, identity: 0.8

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
ccgcacggccaagccagcggagcccgcacc	Protospacer
* ***************  *******.. *

34. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to NZ_CP021368 (Acidovorax carolinensis strain P4 plasmid pACP4.2, complete sequence) position: , mismatch: 6, identity: 0.8

-cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
ccagtac-ctcaatccaggcgagcccgtggc	Protospacer
 *.*.**  .*** *****************

35. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to NZ_CP021364 (Acidovorax carolinensis strain P3 plasmid pACP3.2, complete sequence) position: , mismatch: 6, identity: 0.8

-cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
ccagtac-ctcaatccaggcgagcccgtggc	Protospacer
 *.*.**  .*** *****************

36. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to NZ_CP039965 (Pseudorhodobacter sp. S12M18 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.8

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
ggccgcagccaaggcaggcaagcccgtggc	Protospacer
 * *.*.****** *****.**********

37. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to NZ_CP054618 (Azospirillum oryzae strain KACC 14407 plasmid unnamed4, complete sequence) position: , mismatch: 6, identity: 0.8

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
cggcacggccaagccggacgagcagacggc	Protospacer
***************.*.*****  ..***

38. spacer 10.1|3247606|30|NC_014666|CRISPRCasFinder matches to NZ_CP032181 (Citrobacter freundii strain AR_0116 plasmid unnamed3, complete sequence) position: , mismatch: 6, identity: 0.8

cgcgcggggcggctgacggaa-cgtcccagc	CRISPR spacer
ggcgcggggcggcagacggaaccatcgcgg-	Protospacer
 ************ ******* *.** *.* 

39. spacer 11.1|3547214|37|NC_014666|CRISPRCasFinder matches to MT639643 (Microbacterium phage FreddieHg, complete genome) position: , mismatch: 6, identity: 0.838

cttgccgtccttcccgtccttgccgtccttgttgcag	CRISPR spacer
cttgccgtccttgccgtccttgtcgtccttgtcctcg	Protospacer
************ *********.*********. . *

40. spacer 3.1|1685575|35|NC_014666|CRISPRCasFinder matches to NZ_CP051472 (Rhodobacter sphaeroides strain CH10 plasmid pRspCH10C, complete sequence) position: , mismatch: 7, identity: 0.8

ggatcgttcggccgtcgaagtcggtctcggcgacg	CRISPR spacer
cgttcgagcggccgtcgaagtcggtctcgatgatg	Protospacer
 * ***  *********************..**.*

41. spacer 3.1|1685575|35|NC_014666|CRISPRCasFinder matches to NZ_CP012965 (Rhodobacter sphaeroides strain MBTLJ-8 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.8

ggatcgttcggccgtcgaagtcggtctcggcgacg	CRISPR spacer
cgttcgagcggccgtcgaagtcggtctcgatgatg	Protospacer
 * ***  *********************..**.*

42. spacer 3.1|1685575|35|NC_014666|CRISPRCasFinder matches to CP047035 (Rhodobacter sphaeroides strain DSM 158 plasmid pC, complete sequence) position: , mismatch: 7, identity: 0.8

ggatcgttcggccgtcgaagtcggtctcggcgacg	CRISPR spacer
cgttcgagcggccgtcgaagtcggtctcgatgatg	Protospacer
 * ***  *********************..**.*

43. spacer 3.1|1685575|35|NC_014666|CRISPRCasFinder matches to NZ_CP047041 (Rhodobacter sphaeroides strain 2.4.1 substr. H2 plasmid pC, complete sequence) position: , mismatch: 7, identity: 0.8

ggatcgttcggccgtcgaagtcggtctcggcgacg	CRISPR spacer
cgttcgagcggccgtcgaagtcggtctcgatgatg	Protospacer
 * ***  *********************..**.*

44. spacer 3.1|1685575|35|NC_014666|CRISPRCasFinder matches to NZ_CP015214 (Rhodobacter sphaeroides strain MBTLJ-13 plasmid c, complete sequence) position: , mismatch: 7, identity: 0.8

ggatcgttcggccgtcgaagtcggtctcggcgacg	CRISPR spacer
cgttcgagcggccgtcgaagtcggtctcgatgatg	Protospacer
 * ***  *********************..**.*

45. spacer 3.1|1685575|35|NC_014666|CRISPRCasFinder matches to NZ_CP030275 (Rhodobacter sphaeroides 2.4.1 plasmid pC, complete sequence) position: , mismatch: 7, identity: 0.8

ggatcgttcggccgtcgaagtcggtctcggcgacg	CRISPR spacer
cgttcgagcggccgtcgaagtcggtctcgatgatg	Protospacer
 * ***  *********************..**.*

46. spacer 3.1|1685575|35|NC_014666|CRISPRCasFinder matches to NZ_CP015292 (Rhodobacter sphaeroides strain MBTLJ-20 plasmid d, complete sequence) position: , mismatch: 7, identity: 0.8

ggatcgttcggccgtcgaagtcggtctcggcgacg	CRISPR spacer
cgttcgagcggccgtcgaagtcggtctcgatgatg	Protospacer
 * ***  *********************..**.*

47. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to CP000663 (Rhodobacter sphaeroides ATCC 17025 plasmid pRSPA02, complete sequence) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
cggcccggccaagccagtcgagcgcaagat	Protospacer
**** ************ ***** *. *..

48. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MH590593 (Mycobacterium phage Rabinovish, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

49. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to KX781992 (Mycobacterium phage Gabriel, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

50. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MH697579 (Mycobacterium phage Cane17, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

51. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK112554 (Mycobacterium phage TinyTim, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

52. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359314 (Mycobacterium phage Ewok, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

53. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359337 (Mycobacterium phage Flabslab, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

54. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MN234193 (Mycobacterium phage Kboogie, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

55. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK450432 (Mycobacterium phage ValleyTerrace, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

56. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MH051261 (Mycobacterium phage Tyke, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

57. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MH779502 (Mycobacterium phage FudgeTart, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

58. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359365 (Mycobacterium phage Loanshark, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

59. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359311 (Mycobacterium phage SmallFry, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

60. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359364 (Mycobacterium phage ChickenPhender, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

61. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359303 (Mycobacterium phage Shnickers, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

62. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MH697586 (Mycobacterium phage InigoMontoya, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

63. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK112549 (Mycobacterium phage Morizzled23, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

64. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK112541 (Mycobacterium phage Jessibeth14, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

65. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359347 (Mycobacterium phage Ading, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

66. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK450425 (Mycobacterium phage Shelob, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

67. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to NC_023714 (Mycobacterium phage LinStu, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

68. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359358 (Mycobacterium phage Essence, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

69. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to KJ595575 (Mycobacterium phage Willis, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

70. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MG812493 (Mycobacterium phage NuevoMundo, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

71. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359339 (Mycobacterium phage Naija, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

72. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359333 (Mycobacterium phage JustHall, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

73. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to KT321476 (Mycobacterium phage Zeenon, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

74. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MN428065 (Mycobacterium phage Cactojaque, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

75. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359306 (Mycobacterium phage Norm, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

76. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MN735434 (Mycobacterium phage Mangeria, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

77. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to JN699625 (Mycobacterium phage Wally, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

78. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to EU826471 (Mycobacterium phage Cali, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

79. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to KX721255 (Mycobacterium phage Yucca, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

80. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359366 (Mycobacterium phage Basquiat, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

81. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359346 (Mycobacterium phage NoodleTree, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

82. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to JN699013 (Mycobacterium phage Pio, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

83. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359361 (Mycobacterium phage Darko, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

84. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to NC_023725 (Mycobacterium phage Nappy, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

85. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359348 (Mycobacterium phage Rahel, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

86. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MH779498 (Mycobacterium phage Bread, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

87. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK450427 (Mycobacterium phage Adlitam, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

88. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MG812494 (Mycobacterium phage Pier, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

89. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to GQ303262 (Mycobacterium phage LRRHood, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

90. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MT818423 (Mycobacterium phage Janiyra, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

91. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MH316567 (Mycobacterium phage ParkTD, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

92. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to AY129337 (Mycobacteriophage Bxz1, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

93. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MH051260 (Mycobacterium phage InterFolia, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

94. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to KX721256 (Mycobacterium phage Erdmann, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

95. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359328 (Mycobacterium phage EmmaElysia, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

96. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to KM881426 (Mycobacterium phage ZygoTaiga) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

97. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359335 (Mycobacterium phage Patter, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

98. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MT889395 (Mycobacterium phage Shifa, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

99. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to EU826467 (Mycobacterium phage Rizal, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

100. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MT723944 (Mycobacterium phage ChaylaJr, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

101. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to KR080196 (Mycobacterium phage Momo, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

102. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MH910040 (Mycobacterium phage Sauce, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

103. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MF919495 (Mycobacterium phage Bigswole, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

104. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359318 (Mycobacterium phage Specks, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

105. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to KF024734 (Mycobacterium phage Shrimp, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

106. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK112548 (Mycobacterium phage McWolfish, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

107. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359308 (Mycobacterium phage Shaqnato, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

108. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK112545 (Mycobacterium phage Khaleesi, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

109. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MH825697 (Mycobacterium phage Bangla1971, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

110. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359338 (Mycobacterium phage Amataga, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

111. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359350 (Mycobacterium phage Nidhogg, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

112. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MT723945 (Mycobacterium phage Quasimodo, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

113. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359342 (Mycobacterium phage ShiaLabeouf, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

114. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MH316561 (Mycobacterium phage Derek, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

115. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK112533 (Mycobacterium phage Bonray, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

116. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK450422 (Mycobacterium phage RoMag, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

117. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359327 (Mycobacterium phage EmToTheThree, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

118. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MH727543 (Mycobacterium phage CharlieB, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

119. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to JF704116 (Mycobacterium phage Drazdys, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

120. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359336 (Mycobacterium phage Chargie21, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

121. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359355 (Mycobacterium phage Sprinklers, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

122. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK112534 (Mycobacterium phage Burrough, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

123. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MF919499 (Mycobacterium phage Daffodil, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

124. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359334 (Mycobacterium phage Delilah, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

125. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to NC_023696 (Mycobacterium phage Dandelion, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

126. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MN276192 (Mycobacterium phage Trinitium, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

127. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359324 (Mycobacterium phage Tortoise16, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

128. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MH825713 (Mycobacterium phage Zalkecks, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

129. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359349 (Mycobacterium phage FoxtrotP1, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

130. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to JF704096 (Mycobacterium phage Ghost, complete sequence) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

131. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MN062707 (Mycobacterium phage Grungle, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

132. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359344 (Mycobacterium phage Napoleon13, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

133. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MH727558 (Mycobacterium phage Salacia, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

134. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359363 (Mycobacterium phage Fludd, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

135. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to KX831080 (Mycobacterium phage Lukilu, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

136. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359329 (Mycobacterium phage Kamryn, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

137. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to JQ911768 (Mycobacterium phage Ava3, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

138. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to NC_004687 (Mycobacterium phage Bxz1, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

139. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to NC_011270 (Mycobacterium phage Spud, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

140. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MN183280 (Mycobacteriophage LolaVinca, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

141. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359345 (Mycobacterium phage QBert, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

142. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to GQ303260 (Mycobacterium phage ET08, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

143. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MH744422 (Mycobacterium phage Roots515, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

144. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359321 (Mycobacterium phage Phusco, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

145. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359362 (Mycobacterium phage Atlantean, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

146. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to EU826469 (Mycobacterium phage ScottMcG, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

147. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK310143 (Mycobacterium phage Dietrick, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

148. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK450429 (Mycobacterium phage Bipolarisk, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

149. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MH051266 (Mycobacterium phage MikeLiesIn, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

150. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to NC_029044 (Mycobacterium phage Breeniome, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

151. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MH669008 (Mycobacterium phage Megamind, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

152. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK878897 (Mycobacterium phage Blackbrain, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

153. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK450434 (Mycobacterium phage DrPhinkDaddy, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

154. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359359 (Mycobacterium phage Colt, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

155. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MF919527 (Mycobacterium phage Phox, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

156. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MT818416 (Mycobacterium phage BackyardAgain, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

157. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359330 (Mycobacterium phage Iota, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

158. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to KT365398 (Mycobacterium phage DTDevon, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

159. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to KX369583 (Mycobacterium phage Littleton, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

160. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MF919494 (Mycobacterium phage BeanWater, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

161. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to NC_028869 (Mycobacterium phage HyRo, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

162. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to KT365400 (Mycobacterium phage ErnieJ, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

163. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to KC691257 (Mycobacterium phage Astraea, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

164. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MG872839 (Mycobacterium phage LifeSavor, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

165. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to KC748968 (Mycobacterium phage Gizmo, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

166. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to KC748970 (Mycobacterium phage ArcherS7, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

167. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359353 (Mycobacterium phage BadAgartude, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

168. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MH697590 (Mycobacterium phage Phlegm, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

169. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359317 (Mycobacterium phage FrayBell, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

170. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MT553335 (Mycobacterium phage Ronan, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

171. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MN428066 (Mycobacterium phage JPickles, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

172. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359305 (Mycobacterium phage Teardrop, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

173. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to DQ398053 (Mycobacteriophage Catera, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

174. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MF919513 (Mycobacterium phage Koguma, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

175. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to JN699626 (Mycobacterium phage MoMoMixon, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

176. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to NC_028986 (Mycobacterium phage Alice, complete sequence) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

177. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK450424 (Mycobacterium phage Melpomini, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

178. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to JN204348 (Mycobacterium phage Sebata, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

179. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MN183285 (Mycobacterium phage YoungMoneyMata, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

180. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK450423 (Mycobacterium phage Stubby, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

181. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MF919493 (Mycobacterium phage Audrick, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

182. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to NC_008207 (Mycobacterium phage Catera, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

183. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to JN624850 (Mycobacterium phage Pleione, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

184. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to KX752698 (Mycobacterium phage Tonenili, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

185. spacer 5.1|1888853|30|NC_014666|PILER-CR matches to MK359326 (Mycobacterium phage Pivoine, complete genome) position: , mismatch: 7, identity: 0.767

cggcacggccaagccaggcgagcccgtggc	CRISPR spacer
tggcccggccaagccgggcgagccgggcgg	Protospacer
.*** **********.******** *  * 

186. spacer 10.1|3247606|30|NC_014666|CRISPRCasFinder matches to NC_010510 (Methylobacterium radiotolerans JCM 2831 plasmid pMRAD01, complete sequence) position: , mismatch: 7, identity: 0.767

cgcgcggggcggctgacggaacgtcccagc	CRISPR spacer
cgcgcggagcggctggcggaacgctacgcc	Protospacer
*******.*******.*******.. *. *

187. spacer 3.1|1685575|35|NC_014666|CRISPRCasFinder matches to NZ_AP014705 (Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence) position: , mismatch: 8, identity: 0.771

-ggatcgttcggccgtcgaagtcggtctcggcgacg	CRISPR spacer
cggggcg-ccggccggcgaggtcggtctcggcgagc	Protospacer
 **. ** .****** ***.**************  

188. spacer 3.1|1685575|35|NC_014666|CRISPRCasFinder matches to MK310226 (Halobacterium virus ChaoS9, complete genome) position: , mismatch: 9, identity: 0.743

ggatcgttcggccgtcgaagtcggtctcggcgacg	CRISPR spacer
ggtcctcggcgccgtcgaagtcggtctcgtcaacg	Protospacer
** .* .   ******************* *.***

189. spacer 3.1|1685575|35|NC_014666|CRISPRCasFinder matches to NC_017957 (Tistrella mobilis KA081020-065 plasmid pTM1, complete sequence) position: , mismatch: 9, identity: 0.743

ggatc---gttcggccgtcgaagtcggtctcggcgacg	CRISPR spacer
---tccagctgcggccgccgaaatcggtctcggcgatc	Protospacer
   **    * ******.****.*************. 

190. spacer 11.1|3547214|37|NC_014666|CRISPRCasFinder matches to MT818420 (Microbacterium phage Gilda, complete genome) position: , mismatch: 9, identity: 0.757

cttgccgtccttcccgtccttgccgtccttgttgcag	CRISPR spacer
cttgccgtccttgtcgtccttgccgtcgccctcgtcg	Protospacer
************ .************* .. *.*. *

191. spacer 11.1|3547214|37|NC_014666|CRISPRCasFinder matches to MK737941 (Microbacterium phage Rachella, complete genome) position: , mismatch: 9, identity: 0.757

cttgccgtccttcccgtccttgccgtccttgttgcag	CRISPR spacer
cttgccgtccttgtcgtccttgccgtcgccctcgtcg	Protospacer
************ .************* .. *.*. *

192. spacer 11.1|3547214|37|NC_014666|CRISPRCasFinder matches to MF042361 (Pseudomonas phage Skulduggery, complete genome) position: , mismatch: 9, identity: 0.757

cttgccgtccttcccgtccttgccgtc--cttgttgcag	CRISPR spacer
agcgccgtccttcccgtccttgccggcattctgctgc--	Protospacer
  .********************** *  ..**.***  

193. spacer 11.1|3547214|37|NC_014666|CRISPRCasFinder matches to MT522001 (Microbacterium phage Karate, complete genome) position: , mismatch: 9, identity: 0.757

cttgccgtccttcccgtccttgccgtccttgttgcag	CRISPR spacer
cttgccgtccttgtcgtccttgccgtcgccctcgtcg	Protospacer
************ .************* .. *.*. *

194. spacer 11.1|3547214|37|NC_014666|CRISPRCasFinder matches to NC_047986 (Microbacterium phage Krampus, complete genome) position: , mismatch: 9, identity: 0.757

cttgccgtccttcccgtccttgccgtccttgttgcag	CRISPR spacer
cttgccgtccttgtcgtccttgccgtcgccctcgtcg	Protospacer
************ .************* .. *.*. *

195. spacer 11.1|3547214|37|NC_014666|CRISPRCasFinder matches to MH271292 (Microbacterium phage AnnaSerena, complete genome) position: , mismatch: 9, identity: 0.757

cttgccgtccttcccgtccttgccgtccttgttgcag	CRISPR spacer
cttgccgtccttgtcgtccttgccgtcgccctcgtcg	Protospacer
************ .************* .. *.*. *

196. spacer 11.1|3547214|37|NC_014666|CRISPRCasFinder matches to MT522003 (Microbacterium phage Rie18, complete genome) position: , mismatch: 9, identity: 0.757

cttgccgtccttcccgtccttgccgtccttgttgcag	CRISPR spacer
cttgccgtccttgtcgtccttgccgtcgccctcgtcg	Protospacer
************ .************* .. *.*. *

197. spacer 3.1|1685575|35|NC_014666|CRISPRCasFinder matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 10, identity: 0.714

ggatcgttcggccgtcgaagtcggtctcggcgacg	CRISPR spacer
gcacgtgctcgccgacgaactcggtctcggcgacg	Protospacer
* *.   .. **** **** ***************

198. spacer 3.2|1685638|35|NC_014666|CRISPRCasFinder matches to NZ_CP034185 (Deinococcus sp. S14-83 strain S14-83T plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.714

tccagcgcaggccctgcgggttggtgacgctggtc	CRISPR spacer
gttggtagcggccctgcgcgtcggtgacgctggtc	Protospacer
 ...*..  ********* **.*************

199. spacer 3.2|1685638|35|NC_014666|CRISPRCasFinder matches to MN184886 (Erwinia phage pEp_SNUABM_08, complete genome) position: , mismatch: 10, identity: 0.714

tccagcgcaggccctgcgggttggtgacgctggtc	CRISPR spacer
tgataaggccgccctgcgcgttggtgacgttggtc	Protospacer
*   . *   ******** **********.*****

200. spacer 11.1|3547214|37|NC_014666|CRISPRCasFinder matches to NC_007762 (Rhizobium etli CFN 42 plasmid p42a, complete sequence) position: , mismatch: 10, identity: 0.73

cttgccgtccttcccgtccttgccgtccttgttgcag	CRISPR spacer
tttcacgtcctttccgaccttgccgtccttgacgacc	Protospacer
.**  *******.*** ************** .*   

201. spacer 11.1|3547214|37|NC_014666|CRISPRCasFinder matches to MH444512 (Bifidobacterium phage Willi, complete genome) position: , mismatch: 11, identity: 0.703

cttgccgtccttcccgtccttgccgtccttgttgcag	CRISPR spacer
gagaccgtccttgccgtccttgccgtccttgccatta	Protospacer
   .******** ******************.... .

202. spacer 11.1|3547214|37|NC_014666|CRISPRCasFinder matches to MK932884 (Bifidobacterium phage PMBT6, complete genome) position: , mismatch: 11, identity: 0.703

cttgccgtccttcccgtccttgccgtccttgttgcag	CRISPR spacer
gagaccgtccttgccgtccttgccgtccttgccatta	Protospacer
   .******** ******************.... .

203. spacer 11.1|3547214|37|NC_014666|CRISPRCasFinder matches to NZ_CP011515 (Mitsuaria sp. 7 plasmid, complete sequence) position: , mismatch: 13, identity: 0.649

---------cttgccgtccttcccgtccttgccgtccttgttgcag	CRISPR spacer
gcgaccgtccttgccgtccttgccgtccttccctgcc---------	Protospacer
         ************ ******** **  **         

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	8608247 : 8621090	12	Bacillus_phage(25.0%)	plate,tail	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>NC_014666|8608247:8621090|DBSCAN-SWA
AATGCCCGAGTACCTCACGCCCGGCGTGTACGTCGAGGAGGTGCCGGCGGCGATCAAACCGATCGCCGCGGTCGGCACCAGCACCGCCGGCTTCATCGGTCTCGTCGCCGACGACGTCGAGACACCCCTGCGTCCCGGCCACATCGGCTTCAAAACGGTCGTCGGCGCTGACAACAAGCCGAAGCAGGAGCGCGTCGACACCGACTTCTATCCCGTCGCCGACGCCGGCACGACTGTGCTCGTCGACAGCTGGGACAGCTTCCGCACCCACTTCGGGGACGTCCAGCCCGGCAACACCGTGCTGGCCAACGCGGTCTACGGCTTCTTCAACAACGGTGGCTCCCGCGCCTGGGTCATCCGTGTCGCCGGGCCGGCCACCGATGCCGGCACCGGTACGCCGGCGGCGCCGGCCACCGAAACGGACGGGAGCACGAAAACGGACGGGAGCACGGACACCACCGTCGGTGACCCGCCCGCCGAGGGCACGGACACCACGGCCACCGACACCACGGCCACCGACGGAACGGGCACCGAGGCCGGCGAGGACGTCGAGCCCGTCGGCGTCGACACGGACCCCGCGGTCCAGGCCGCGCTGATCAGCGCGCTGGACGCCTTCCTCGACGTTGACGAGATCTCCATCGTCGCGATTCCCGGGGCGATCAGCGACGACGTCCAGAAGGCGATCGTCGACCACTGCGAGAACGAGAACACCCAGGACCGTTTCGCCGTCCTCGACGGGCGGCGGGGGGTCACGGAACTGACCAAGACCGACATCGCCGGCAACGTGCGGGACAGCAGCTACGCCGCCGTCTACTTCCCGTGGATCGCGATCGGCACCGACGCGGTTGGCAAGCCGATCTACCAGCCGCCGAGCGGCCACGTGGCCGGCGTCTACGCCCGCGTCGACACCAGCCGCGGCGTCCACAAGGCGCCAGCGAACGAGGTCATTCGCGGCGCGAACGGGGTCGAGACGACGGTCGGCAAGGCCGCGCAGGCCGGGCTGAACCCGGACGGCGTCAACGTGATCCGCATGTTCGGCCCGAACGTCACGATCTGGGGCGCCCGCACGACCGCCGCCGTCAGCCAGCCGGAGTGGAAGTACGTCAGCTCCCGGCGGCTGTACATCTTCGTCCGCGAGTCCATCCAGGACGGCCTGCGCTGGGCCGTCTTCGAGCCGAACGGCCCGGACCTGTGGTCCCGGGTGCGCCGCAACGTCACCGCGTTCCTCACCACCGTGTGGGCCGACGGCGCGCTGCTCGGCACGACCGCTGAGCAGGCTTTCTACGTGCGGTGCGACGAGGACACGAACCGCGTCGACGTGCGGAACGCCGGGCAGCTCGCTACCGAGGTCGGCATCGCCCTGCTGAACCCGGCAGAGTTCGTCGTCTTCCGGATCAGCCAGTGGGCCGGCCCCGCGGCATGATTCCGGGGTTGCGGCGGGAGGACGTGCGCCCGTCGGAGCCCCGGAGCTTCGTCACCGGCGTCCCGCTGTTCCTCGGCTTCGACGCCGCCGCCGGGCCGCCCGGCACGGTCGTCGGGCCCGAGCGGCTCGGCACGGTGGGTGACCTGACCGCGGCCAGCCTGGCCGGGGTGGCCAACCCGGCCAGGCCAGGCGCCGCGGGAGTCGCGGCCAGCCTGGCCGCCGCCGCGGCGCGGGCCGAGGGCGCGCTCGGCGACGCCGTCCGCGGCTTCTTCGCGAACGGCGGCCGGGCCTGCCACGTCGCCTGGACCGCGCCGGGCCCTGACGCGGCAGCCGCGGTGCGCCTGGCCCTGACCACGCTGGACGACCGGGCCGAGCTGACCGACGTCGATCTGGTCTGCCTGCCCGACCTGGGCGCGTGGCCGCGGCCGGCGGAGATCGCCGCCGCCCAGCGGGCCGTGCTGGAGCACTGCGCGGCCCGCGGCGACCGCTTCGCCGTACTGGACGCGGTGCCGGGAGCGGACCTCGACGCCGCGGTGAAGCAGGCCCAGAACCTGGCCGGGCCGGCCGCCGCGTTCGGCGCGCTGTACTTCCCGTGGGCGCGGGTGCCGGCGGACGGCGCCGCCCGGTACGTGCCGCCGTGCGGGCACATCGCCGGCACCTACGCGGCGCTCGACCGGGCGGGCGGCGTCCACCGGGCGCCGGCGAACCGCGAGATCGCCGGCGTGCTGGACGTGTTCGTCGACCTCACCGAGGCGGACATGGCCCGGCTGTGCGAGGCCGGGGTGAACCCGATCCGCGCGCTGCCCGGCCGGGGCATCCGGGCCTGGGGCGCCTGGACGCTGAGCGACGACGAACGCTGGGCGAGCATTCCCGTCCGCCGGCTGGTGTCGACGATCGGGCGCTGGGCGCGGCGGTTCCTGGAGACGGCGGCGTTCGAGCCGAACGACGTGCGGCTGTGGACACGCGTCATGCGCGAGCTCACCGCGGCGCTGGACGTGCTGCACGCGGCCGGGGCCTTCGCCGGACGGGTCGCCGAGGAGTCCTTCTACGTCAAGTGTGACCACGAGACGAACCCGCCGGAGTCGGTCGCGGCCGGCCTGGTCGTCACCGAGATCGGGGTGGCGCCCGCCGTCCCCGCGCAGTTCATCGTCGTCCGCCTGATCTCCAGCGCGTACGACGCCACGGTCGACGCGGCCTGACCCGGTCGCGAGAGGAGTGTCACGATGGCGACCCGTATCGACCCGTACAACGGGTTCACGTTCTCGGTCGAGCTCGACGGGATCACCCGGGCCGGGTTCCGGGAGTGCTCTGGCCTGCAGAACAGCCAGAACGTCAGCACCTACCGGGAGGGCACCGACCGGTACCTGAGCCCCCGGAAGATCCCAGGCATGGTCACCTACGGTGACATCACCCTGAGCCGCGGCATCACCAGCGACACGAAGCTGTGGGAGTGGCGGCTCAAGACGGTGCGCGGCGACGTGCAGCGGCACAACATCTCCGTCAGCGTGCTCGACGACGCAGGCACGGCCAAGATCACCTGGAACCTGTTCGACGCGTGGCCGACGAGCTGGACCGGGCCGTCGTTCAACGCGACGTCGGACGAGTTCGCGATCGAGCAGATCACCATCGCCTACGAGCGCCTCGAGGTCGGCCAGTGGTCCTGACGGGCGCCGCCGCGGCGGGCCTCTTCGCCGGCCCGGACAGCCCCGACGGCGGCTCGGGCGCGGCGGCGGGCCTCGGCCCGGACGGCGGCCCGGGTGAGTTCCCGACCGAGTTCCCGTTCGAGCTGCCGCGCGGCCTGCTCGGGCCGGACGGCGCCGTCCACCGGACCGGGACGATGCGGCTGGCCACGGCGTACGACGAGATCGAGCCGCTCAAGGACCCGCGGGTGCGAGCCAACCCCGGCTACCTCGTCGTCATCCTGCTGGCCCGGGTGATCATCCGGCTGGGGACACTCGAGCACGTCAACACGGCCGCGATCGAGCATCTGTACGCCGCCGACCTGGCCTATCTCCAGGACCTGTACCAGCGGATCAACCTGACCGGCAGCACCCGCCTGGCGGTCGCCTGCCCCCACTGCGCCGGCGATTTCGAAGTGGAGACGTCCGGCCTGGGGGGATGACCCGCTACCCCTTGGACCGGCTGCACGAGGAGGTGGCGTACGTGGCATTCCACTTTCACTGGCGACGCGAGGACATCCTGCGGCTCGAGCACCGCGAGCGGCAGCGCTGGGTGAGCGAGATCGCCCGGCTCAACGAACGACTCCAAGCGGGCGGGCGAGGTTGACATCCTCCCCGCGTGAATGCGGGGGTACTCCAACTTCGGCAACCCGACGCCTCCCCACACAAACCGCGCATGCTCACAATGCGCCTACATTCCCGCCACCTGTTCGGGTATTGGGTAGAGCCGGTAACGAAACTTGACCCTATTTTGGTAGAGAAAGGCGACAGAATGCCTTACCGCGGGCACCGTTTCCTTCCCGGCCTGAAGGCCGGAGCATCCACGGCGCCGCTCCGGTGACGATCGGACTGCGCTGGCAGCCGGCCGCGATCGGCAACTGGCCGGCGGCGGCGCGCCCGCTCGAGCCGTTCACCGGCTTCAACTTCGCGGTCGAGATCGAGGGCCTGATCGTCGGCGGCTTCACCAGCGTCGAGGGCCTGGAGAGCGACCTGCGGACGATCGAGTTCCGGGAGGGCGGCGTCAACGGCTACGTGCACCGGCTGCCCGACGGGGCGAACGCGTCCACGATCGTCCTGCGGCACGGCCTGACAGCCAACATCTCGCTGTGGACCTGGTACGACAACACCGTCCGGGGCGTCGTCCAGCGGCGGAACGGGACGATCGCGCTGCTCGACCGCCAGGGCGTCCCGCTGGTGTGGTGGAACTTCCGGCGCGCCCTGCCGGTGCGCTGGAGCGGTCCGGCGCTGGCGGCGGACAGCGACGCGATCGCGGTCGAGTCGATCGAGCTCGCGCACGAGGGCCTGAGCATGCCGCTGGCCGGGCAGGCGCTCGCCGCCGCCCAGGCGATCACGGGGATGGGGCGGTCATGACGGCGCCGCTGACCGGGGGAAGCGGCGGGCGCGCGGGCGGCCCCGAGTCCGGGCCGACGGCACCGGGGCTGGCCGTCGACGCGCGGTTTCTCGCACGCCTGCGCGGCCGGAGCCGGCAGGCCGGCCTTCTCGACCTGACGCCCGGCCGTGCGCTGGCCACGCGACACGAACGGATGATCGGCGGCGCTCCGCTCGCCGCGGCCGTTCTGGCTCGTTCCGACGCGCGGCCCCGGTCGGAGGAGGCCCGTGAGCTGCCGGTCGTGGCGGCGCGCGCGCCGGAACCGCTGTCGGTGGACGTCGCCGGGGCCGGCCGGGCCACGCGCCCGTCGGCCCGGCCGGGGACACCGGTGGTGAGCGCGGCGCCGCCGCCGCGCGAGTCATCCCCGTCCGAGCCGCCGAGCGCGGTCCGGCCGCCCCTCGCGGTCCGGCCGGCGAGCACCGTCCAGCCTGTGAGCACCGTCCAGCCTGTGAGCACGGTCCAGCCGGTGCCCGCGGTCCAGCCGGCCCCCGCGGCGACGCCGGTGGCTCGGGTCACCCCGCCGACCAGCGCGCCGCCGAGGGCCGCGGGGGCGCCGGTCATCCGCCGGCTCGTGCGCGGCGGCCAGCGGGGCGCCTCCCCCTCGTCACCGGTCCCGCCGTCAGCACCGTTACCGGCCTCGCCGCCGGACCCCGATCAGGCAGCCGCTTCGGCGCCCCCACGCTCGCGCCTCGCGGGGCCGGCCCTGCCGCCGGATCGTCCTTTCGTCGTCGCCGCGCCCGCGCCGGAGCGGCCGGTGGCCCCGCTCCTCCAGCTCGCCCCCGCGGCGGCCGGGTCTCCGGTGGTCGTGCCCGCTGGCGTCGAGGCGCCGGCGATGCCGGTGGTGCTCCCGGCGCGGGACGAGCGCCCGCTGCCCGTCGTCCGCCCGGCTCCCGCCCGAACGACGGCGCCACTCGGCGCGACCCCCCTGTTCGGGCCAGCCCTGTTCGCGCCAACACCGTCGGGACTCGCGCCGTCCGGGGCCGCGCCGTTCGGACCGGCGGTGCCCGGGCTCGCCGCGCTGCCGCTGGCCACGCCGCCCACCGCGGCTTTCGCCCACGCCGCGGCCCCCCAGCCGACGGCGGCCGCTCCGGCCGGTTGGCCCGCACCGGTTCGGGACGCGCGCGCGAGCCAGCGGCCGGAGCCGGCCCGCCCGGCACCAGCAATGCCGGCCCCGGCGGCGCCGCTGGACCTCGACCGGCTCGCGGACGCGGTCGGGCGCCGGATCGTGCGCCGCTTCGGCGTCGAGGCGGAACGGCGAGGGATGCCGCGATGACCCTCATCAACCCGCCCGCGGGCGGCCCGCGTGGCGACAGCCTGGAGAAGCTGACGATCTTCTACCGGAAGGACGGCGTGGAACCGACCTTCGTCGAGGCGCTGTTCAACCCGGCCGAGATCAGCCGGTCCCGGACGATCGAGTGGGAGAAGCCGGTCGCCGGCCTGATCGCCAAGGTCCCGTACCAGCCGCGGCGCGATTTCGTCGCCGTGCGGCCGGAGACGCTCTCGGTGTCGCTGTTCTTCGACACCTGCGAGTCGCGGGCCGACGCCGACAGCCGCGTCGCCGGCCTGCTGACGAACCTGGCCGCCCCCGGCAGCCCGTTCGACAGCGGCACGGCCAGCGACGTCACGCGCCTGACCCGCCGGGTGGTGGAGCTCGCCCAGGTCGACCGCGAGACGCACGAGCCCCCGGTGTGCCAGCTCAGCTGGGGCCGCTACGCGCACATCTTCACCGGGGTGCTCACCCAGCTCGACCAGCGCTTCACGATGTTCCTGCCGGACGGGACGCCGGTGCGGGCGACGCTGGACTGCACGTTCGCCGAGTCCCCCACCCTGGCGGCGGCGCGGGCCGGCGAGCTGCACTCGGCCGACGTCGTCAAGTCACGGGTGGTGCGCCGCGGCGACACGCTGCACAGCATCGCCGCGCGCGAGTACGGCGACCCCGCGCTCTGGAAGGAGATCGCGCGGGCCAACGGCATCACCAACCCGCTGCGGGTCTCCCCCGGCACGGTGCTCACCATCCCCCGGCTGGACGGGTAGGGCCGGTCGATGCCCAGCGCAACGAGCGGGATCCCGGCGCTCCCGACGCCGACCGTGCGCCTCGACGGCGCCCAGCTGCCGCCGGAGGTCCAGCGCGACCTCATCGCGATCCGGATCGAGCAGGACCTCGGCGCCATCGGCATGCTCACCCTCGAACTGCGCAACTGGGACGCCGCCACGCAGCGCCACACCTGGTCGGACTCGTCGCTGCTGGCCGTCGGCACCGGCATCGAGGTCTGGCTGGGCGGCCCGGGCGCCCCGTCGGCCTTCCTGGGCGAGGTCACCGGCATCGAGCCCGTCTGGGCGCCGGATCGCTCACCGACCGTGACGGTGCGGGCCTACGACTACCTGCACCGGCTGACCCGCGGGAGCGTGACCCGCACCTTCGTCGACGCCAGCGACAGCGACATCGCCAGCCGGCTCGCCCGCGAGGCGGGCCTGCGCGCGCGGGTGACGGCGACCGGCACCCGTCACCGGCACGTGCTCCAGTCCAACCAGACCGATCTGGAGTTCCTCCGCTCCCGCGCCCGCCGCCACGGCTTCGAGGTGTTCGTGCGCGACCGGGAGCTCCACTTCCGGGAGCCGGCGCTCGGGGCGCCCGTGACCAGTGTGCTGCGGGTCGGGGACGAGATCGAGCATTTCGTGGCCTGGCTGAGCGCGGCCGGCCGGGCCGGGCGGGAGACCGTGCGGGCCTGGGACCCGCGGGCGAAGGAGGCCGTCGTCGGGTCCGGGGAGAGCCAGGTCCTGCCCGCCATGGGCGGCGCGGGCGTGGGGCAGCGCCAAACCGACACGATCTTCGGCCGGGCCACCGTCACCACCGCGGACGTTCCCGTGCGGACCCGGCGGGAGGCCGAGGAGCTCGCCCTGGGCCGGCTGCGGACGTCCGCCCTGACCTACGTCGAGGCCGAGGCGGAGGGCGGCGACGCGCTCGCGCCCGTGCGCGCGGGCACGACGGTCGGCGTCCAGGGCGCGGGGACCCGGTTCAGCGGCACCTACTACGTGGCCCAGGTCGTGCACACCTTCGCCTACGACAACCGCTTTCGCTCCTCGTGCCAGCTGCGCCGGACGTCGGCATGAGCGGCGGGATCTACGAGCGGCTGCTCGGCGCCGGCACCGGCGACGTCTTCGCCGGGGTGGCCGTGGGCATCGTCACCAACGTCAAGGACCCCGACAGCCTCGGCCGGGTCCGGCTGCGGCTGCCCTGGCTCGCGGACGACGTCGAGAGCGACTGGGCGCGGGTGGCGACGCCGATGGCCGGCAACGGGACGGGTGCGCAGTTCCAGCCCCGGGTCGACGACGAGGCGCTGGTCGCCTTCGAGCACGGCGACCCGGGCACGCCCTACGTCATCGGCTGGCTGTGGAACGGCCGCGACGCCCCGCCGCAGCCGGACACCAGCGGCCGGGGCGACGTCCAGGTGCTGCGCTCGCGGTCCGGCCACGTCGTCCGCCTGGACGACACGAAGGACGGCGAGCGGGTCGAGATCATCGCGAAGGGCGCCCGGAGCAGCATCGTGATCGACGTCGTCGGGCGGACCGTGACAGTCACCGGGGAGTCCGACGTCGTGATCGAGGCCGCCGCCGGGCGGCTCACGCTTCACGGCAAGGCCGGGGTCGAGATCACCTCGGACAGCACGGTGAAGGTCGACGGGAAGGCCGGCACGGAGGTCACGGGCGGGCCGCGGCTGACCCTCAAGGGCGCCGTCGTCAACATCAACTAGCGCGATCGCCTGTCGAGGAGGGGGACGGACGTGGGACTACCCGCGGCCAAGGAGGGGGACCGGGTCATGGCGACCGACATGCACGTCGTCGTGCCGCCCGCGCCCGCGACGCCGGTGCTGACGCCGTTGCCGTTCGTCGGCGCGCTCACCGGCGGCCTCAGCCCGAACGTCAACATCATGGGACGGCCGGCGGCGACGGTCGGGAGCACCGCCGACAACGTCCCGGGGCACGTGCCACCGGGCGGGGTGTTTCAGCGCCCGCCGTCGAACCGGGGGACGGTCCTTCTCGGCAGCGCGACCGTGATGATCAATGGTCGGCGGGCGGCCCGGTCCGGCGACCCGGTCGAGACCTGCAACGACCCGACCGACCTGCCGGCGGGCACCATCGTCGCCGCCGGCTCCGTGCTGATCGGCTGAGGCGCGCCGTGGACATGAGCGTGGGCGGCGGCGTGAGCTCCGGGTTCGGTGGATCCGGCTGGGCCTTCCCCGTCACCGTCACGGCCGACGGGACGATCCGGTCGGTCGCGGACGAGGACGAGATCATCCGGGCCGCGATCTGGATGATCCTCAGCACCTCGCCCGGCGAGCGGGTGATGCGGCCGGACTACGGCTGCGGCCTGTCCGAGCACGTCTTCGGCGTCCTCGGCCCGGCGACGACGGCCGGGATCGAGCGGGACGTCACCGACGCGCTGCGCCGCTGCGAGCCACGCATCGACGTGCTCGAGGTCCAGGCTCGCCCGGACGCCGACGACCACGACGTCCTGCTGGTCGAGATCACCTACCGGGTGCGAGCCACCAACAGCCGGCTCAATCTCGTCTACCCCTTCTACCTGGACTGACGGATTACCTTGACTGACGGAGCGGACGTGTTGAGGAAACCGGAAAGCGCCCAGGCCGGGGCCACCGGGAGGCGGCCGTGACGCCTCAACCGCCGTCGCAGCCGCCGCCGTTCGAGCCGCGCGATCGCGGCGAACTGGCCGCGTGGACGACAGAGCTGGCCCAGCGCTACAGCACGTGGCGGCCGGCCGCCGACGGCTCGCCCGACCTCGGCTCGGCGCTCATCGCGATCGCCGCGCACTTCGCCGGGCACGTCGGCGAGCGGCTCAACCGGGCCGGCGACCTGGCCTACCTGGCGTTTCTCGACCTGGTCGGCGAGCACCCGGCGCCGGCCCGGCCCGCCCGGGTGCCGCTGACCTTCACCGCCGCGCCGGGTGTCCCGGCCGGCGTGACGGTGCCGGCCGGGACGCCCGTGGCCGCCCCGCCGGACGCGGGCGACCCGGGTTCGGGTGACCCGAGCGCGGGTGACCCGGCCGAGACCGTGACGTACGAGACCGACGAACCGCTGGTCATCTCGCCGGCCCGGCTGCGGCATCTCGTCGTCACCGACCCCGCGCACGACACGTGGACCCGCGTCGAGGTGCCGGCCGACGGCGGGCTCACCGACGGACTGAACGCGTTCACCGGCACCGAGCCGGTCGGGCACGAGCTGTTCGTCGCGCACCCGCTGCTGGCGTCGGACGCGCCGCGGGCACTGACGGTCAGCACGACCTCGCCCGGCCTGGAACCGTGGAGCGCCACGCCGGCCACCTGGTCGCGCTGGGACGGCTCGGCCTGGACGGACCTGGTCGCCGAGTCCGGGACGGCCACCATGTCGCTCGGCGGACCGATGACGATCAACATGCGGTACGCGCCCGCGCTCGGCTCCCAGCCGCGCGAGGTTGCCGGCGTGACGGGCCACTGGCTGCGGGGCGAACTCACCGTTCCGCTGGTCACCGGCGCGGCCGCGCTGCCGCCGACCGCGGTCGCCGTCGGCCGCCGCCCACCTGAGGCCCCCGCGCCCGGGCTGGCGCCGTTCGGCGTCGAGGGCCAGGTCAGATGGTTCTACCTGAGCGTGCCGCCGCCCCCGGCCGGCGCGGCCGGCACCAGCATCCGGATCAGCGTCACCGCCGCCCGCTGGGGCCAGGCGAGCGCGGCCCGGCCGGTCGTCCTGGACTGGACCTACCGGGTCGGCGACAGCTGGAAGCCGCTGGGTCGGGCCCGCAGCGACGGCGCCGCCGAACCGTCCGGCTCAGTGCCGCCCGGCTCAGTGCCGCCCCGGCGTTTCATCGACGCGACCCGAGCGTTCACCGGGCCCGCCGGCGACGAGGGCGACGGCGGGGACGACGGGGACGGGGACTGGGTCGCCGTCGGCCTGCCGGACGACCTCGCCCCATCCGTGCTGAACGGGGTGGAGGGACGCTGGCTGCGCGTCGAGCTGGTGCAGACGGAAGGCGCCTACGACGTACCGCCGATCGTCGACGCGATCGAGGTCGCCTACGAACGGCCGACGGCCCGGCTGCTCGACCTCACCCTCACCCGGGACGCGGCCGAGACGGCGCCGGTGCCGGTGCCGGCGGCGTTCGCCGACGGCGTCGAGCTCGACCTCAGCCGGTCCGTCCGGCCGTTCGGCGCGCAGCCGGCCTACGACGACACGCTCTACCTGGAGTGCCCCGAGGCGCTGGCCGCCGCGGCGACGCTCACCCTCGTCGTCACCGTCACGAACGCGACGGGGAAGGCCGCGGCGGCGCCACCGCTGCCGACCGTGACGCTCACGCCGCCGATCGGGTGGGAGACCTACGACGGCGCCCGTTGGCTCCCGGTCCGCTCGGTGAGCCGGGCCGACGCCTTCACCGTCGGAGGGGACGTCACCCTGGCGCCGGCCGCCCCGTCCCAGCCGACCGAGGTCGGCGGCCGTGCCGCGCACTGGGTGCGGGCCCGGCTGCTCGGCGACTACGGCGCGCCGGCCGGCTACCGGTCGGTCCAGGACAGCAAAGGCGCCTGGACGGTCGAGTACTCGCCCGCCACCCTGGCCCCGCCGGTCCTGGCTGACCTCGGCTGGCGGCCGCTGACAGTCACCAGCGGGCTGCCGGAGGTCCTGGTCACCCGCAACGCCGGGTTGGAGACCGTCCACCGGCTCGCGCCGGGCCAGTGGCTGACGACGATCCGGAGCGAGGGCGGCGACGGTCTGGTCCCGTTCGTCGGCTCCGACGAGTCCGACCCGGCGCTGCACCTGGGCTTCGAGGGCGACTTCGGCCAGGAGCCGGTCACGCTGTTCTTCCCGGTCAGCCCGCCGCGGCCCCAGGACGTCGCCGGCGACGGCGGCGCGGCCGGCCCGGAGGGCGGGACGGGTGTCTCCGCCCTGTCGCTGGTCTGGGAGTACTCGGGCCCGCGGGGCTGGCAGCCGCTGGCCGTCGTCGACGCCACCGGCGGGCTCGCCGACCCGGGCACCGTACGGTTCGTCGGCCCGCCCGACCAGGCGCCGCGCACGGTCGCGGGCCGCGACGGCTACTGGGTGCGGGTCCGGGCGGCCGGCGGCGAGCCGCCGTTCGCGCCGATGCTGCGGGGCGTGCTGCCGGACACGGTCTGGGCGACCGAGGGGTCGACAGTCGGCGAGGAGATCCTCGGCAACGGCACCGGGACGCCCGGTCTGACAGTGAGCACGGCGCACACCCCGGTGCTGCCCGGCGAGCGCCTGGTCGTGCGCGAGGCCACCGATCCCACCACTGGCGAGGACGTCTGGGTGAGCTGGACGGCGGTCGGCGATCTGCGCGCGTCCGGCCCGGCCGACCGGCACTTCGCGCTCGACCGGTTCACCGGCGTGATCCGTTTCGGGGACGGGCTGGCCGGGCGGATGCCGCCGCCGGGCGAGGGCAACATCAGGATCGGCTACCGGTACGGCGGCACCGAGGCCGGCAACCGGCCCGCGGGCACGATCACCCAGCTCGCCGTCGCGGTCCCGGGCCTCGACGCCGTGGTCAACCACCTGCCGGCCGAGGGCGGGGCCGACCGTGAGTCGCTGGCCGACATCCGCGACCGCGGCGCGCGCACGCTGCGGCACCGGGACCGCGCGGTCGCCCCCAGCGACCTGGAGGATCTGGCCCTGGCGGCGACGGGCGAGGTGACCCGGGCCCTGGCGGTGGCGCCGAGCGGCTACGACCCGTTCGACCTGTGGTTCGGCGCGGACGAACCGACGCCGGCCGACGCCTGGGCGGCGGCCGGCCCCGGCCAGGCCGGGGTGGTGATCGTCCCGCGCGCCGGGGGCGACCGGCCGGCGCCGAGCCCGGGGCTGATCGGCGAGGTCCGCGCGTACCTGCTGGAGCGGGCGCCCGCGACGGCGCGGGTGTGGGTGGTCGGCCCGGAGTGGATCGAGGTCACCGTCGTCGCGACCGTCGTGCCGGAGCCGGACGCCGAGCCGGGCGCGCTGCGGCAGGCGATCCGCGACCGGCTGCGGGCCTTCCTGCACCCGCTCACCGGCGGGGACGGCGCGGTCGGGAACAGCGGGGGCAGCGGCCCCGGCTGGGACTTCGGTCACGAGCCGCGCCGCTCGGACCTGTTCGCGTTGCTGCACCGGGTGCCCGGCGTCAGCCACGTGCGCCAGCTCGACGTCCGCTCGACGCCGGCGGTGGACTCGGAGGCCTTCGCGGACCGGATCACCGCTGTCCTGGACCGACCGCTCGACGCCGGAGTGGACGCGGCGACCGACGCCGAGGCGCGGCGCTGGCTGGAGCGGGCGCTCGTCTTCTCCGGCGACCACCAGATCACCCTGACCGAGACAGGCTGA

Protein sequences of DBSCAN-SWA_1

>NC_014666|8608247:8621090|8612218_8612719_+|WP_157735630.1|tail|DBSCAN-SWA
MGNWPAAARPLEPFTGFNFAVEIEGLIVGGFTSVEGLESDLRTIEFREGGVNGYVHRLPDGANASTIVLRHGLTANISLWTWYDNTVRGVVQRRNGTIALLDRQGVPLVWWNFRRALPVRWSGPALAADSDAIAVESIELAHEGLSMPLAGQALAAAQAITGMGRS
>NC_014666|8608247:8621090|8609677_8610868_+|WP_157735214.1|tail|DBSCAN-SWA
MRREDVRPSEPRSFVTGVPLFLGFDAAAGPPGTVVGPERLGTVGDLTAASLAGVANPARPGAAGVAASLAAAAARAEGALGDAVRGFFANGGRACHVAWTAPGPDAAAAVRLALTTLDDRAELTDVDLVCLPDLGAWPRPAEIAAAQRAVLEHCAARGDRFAVLDAVPGADLDAAVKQAQNLAGPAAAFGALYFPWARVPADGAARYVPPCGHIAGTYAALDRAGGVHRAPANREIAGVLDVFVDLTEADMARLCEAGVNPIRALPGRGIRAWGAWTLSDDERWASIPVRRLVSTIGRWARRFLETAAFEPNDVRLWTRVMRELTAALDVLHAAGAFAGRVAEESFYVKCDHETNPPESVAAGLVVTEIGVAPAVPAQFIVVRLISSAYDATVDAA
>NC_014666|8608247:8621090|8616520_8616907_+|WP_013428132.1|DBSCAN-SWA
MGLPAAKEGDRVMATDMHVVVPPAPATPVLTPLPFVGALTGGLSPNVNIMGRPAATVGSTADNVPGHVPPGGVFQRPPSNRGTVLLGSATVMINGRRAARSGDPVETCNDPTDLPAGTIVAAGSVLIG
>NC_014666|8608247:8621090|8612715_8614011_+|WP_013428128.1|DBSCAN-SWA
MTAPLTGGSGGRAGGPESGPTAPGLAVDARFLARLRGRSRQAGLLDLTPGRALATRHERMIGGAPLAAAVLARSDARPRSEEARELPVVAARAPEPLSVDVAGAGRATRPSARPGTPVVSAAPPPRESSPSEPPSAVRPPLAVRPASTVQPVSTVQPVSTVQPVPAVQPAPAATPVARVTPPTSAPPRAAGAPVIRRLVRGGQRGASPSSPVPPSAPLPASPPDPDQAAASAPPRSRLAGPALPPDRPFVVAAPAPERPVAPLLQLAPAAAGSPVVVPAGVEAPAMPVVLPARDERPLPVVRPAPARTTAPLGATPLFGPALFAPTPSGLAPSGAAPFGPAVPGLAALPLATPPTAAFAHAAAPQPTAAAPAGWPAPVRDARASQRPEPARPAPAMPAPAAPLDLDRLADAVGRRIVRRFGVEAERRGMPR
>NC_014666|8608247:8621090|8616921_8617329_+|WP_041259842.1|DBSCAN-SWA
MSVGGGVSSGFGGSGWAFPVTVTADGTIRSVADEDEIIRAAIWMILSTSPGERVMRPDYGCGLSEHVFGVLGPATTAGIERDVTDALRRCEPRIDVLEVQARPDADDHDVLLVEITYRVRATNSRLNLVYPFYLD
>NC_014666|8608247:8621090|8608247_8609669_+|WP_013428122.1|tail|DBSCAN-SWA
MPEYLTPGVYVEEVPAAIKPIAAVGTSTAGFIGLVADDVETPLRPGHIGFKTVVGADNKPKQERVDTDFYPVADAGTTVLVDSWDSFRTHFGDVQPGNTVLANAVYGFFNNGGSRAWVIRVAGPATDAGTGTPAAPATETDGSTKTDGSTDTTVGDPPAEGTDTTATDTTATDGTGTEAGEDVEPVGVDTDPAVQAALISALDAFLDVDEISIVAIPGAISDDVQKAIVDHCENENTQDRFAVLDGRRGVTELTKTDIAGNVRDSSYAAVYFPWIAIGTDAVGKPIYQPPSGHVAGVYARVDTSRGVHKAPANEVIRGANGVETTVGKAAQAGLNPDGVNVIRMFGPNVTIWGARTTAAVSQPEWKYVSSRRLYIFVRESIQDGLRWAVFEPNGPDLWSRVRRNVTAFLTTVWADGALLGTTAEQAFYVRCDEDTNRVDVRNAGQLATEVGIALLNPAEFVVFRISQWAGPAA
>NC_014666|8608247:8621090|8617406_8621090_+|WP_013428134.1|plate|DBSCAN-SWA
MTPQPPSQPPPFEPRDRGELAAWTTELAQRYSTWRPAADGSPDLGSALIAIAAHFAGHVGERLNRAGDLAYLAFLDLVGEHPAPARPARVPLTFTAAPGVPAGVTVPAGTPVAAPPDAGDPGSGDPSAGDPAETVTYETDEPLVISPARLRHLVVTDPAHDTWTRVEVPADGGLTDGLNAFTGTEPVGHELFVAHPLLASDAPRALTVSTTSPGLEPWSATPATWSRWDGSAWTDLVAESGTATMSLGGPMTINMRYAPALGSQPREVAGVTGHWLRGELTVPLVTGAAALPPTAVAVGRRPPEAPAPGLAPFGVEGQVRWFYLSVPPPPAGAAGTSIRISVTAARWGQASAARPVVLDWTYRVGDSWKPLGRARSDGAAEPSGSVPPGSVPPRRFIDATRAFTGPAGDEGDGGDDGDGDWVAVGLPDDLAPSVLNGVEGRWLRVELVQTEGAYDVPPIVDAIEVAYERPTARLLDLTLTRDAAETAPVPVPAAFADGVELDLSRSVRPFGAQPAYDDTLYLECPEALAAAATLTLVVTVTNATGKAAAAPPLPTVTLTPPIGWETYDGARWLPVRSVSRADAFTVGGDVTLAPAAPSQPTEVGGRAAHWVRARLLGDYGAPAGYRSVQDSKGAWTVEYSPATLAPPVLADLGWRPLTVTSGLPEVLVTRNAGLETVHRLAPGQWLTTIRSEGGDGLVPFVGSDESDPALHLGFEGDFGQEPVTLFFPVSPPRPQDVAGDGGAAGPEGGTGVSALSLVWEYSGPRGWQPLAVVDATGGLADPGTVRFVGPPDQAPRTVAGRDGYWVRVRAAGGEPPFAPMLRGVLPDTVWATEGSTVGEEILGNGTGTPGLTVSTAHTPVLPGERLVVREATDPTTGEDVWVSWTAVGDLRASGPADRHFALDRFTGVIRFGDGLAGRMPPPGEGNIRIGYRYGGTEAGNRPAGTITQLAVAVPGLDAVVNHLPAEGGADRESLADIRDRGARTLRHRDRAVAPSDLEDLALAATGEVTRALAVAPSGYDPFDLWFGADEPTPADAWAAAGPGQAGVVIVPRAGGDRPAPSPGLIGEVRAYLLERAPATARVWVVGPEWIEVTVVATVVPEPDAEPGALRQAIRDRLRAFLHPLTGGDGAVGNSGGSGPGWDFGHEPRRSDLFALLHRVPGVSHVRQLDVRSTPAVDSEAFADRITAVLDRPLDAGVDAATDAEARRWLERALVFSGDHQITLTETG
>NC_014666|8608247:8621090|8615845_8616490_+|WP_013428131.1|tail|DBSCAN-SWA
MSGGIYERLLGAGTGDVFAGVAVGIVTNVKDPDSLGRVRLRLPWLADDVESDWARVATPMAGNGTGAQFQPRVDDEALVAFEHGDPGTPYVIGWLWNGRDAPPQPDTSGRGDVQVLRSRSGHVVRLDDTKDGERVEIIAKGARSSIVIDVVGRTVTVTGESDVVIEAAAGRLTLHGKAGVEITSDSTVKVDGKAGTEVTGGPRLTLKGAVVNIN
>NC_014666|8608247:8621090|8610892_8611333_+|WP_013428124.1|tail|DBSCAN-SWA
MATRIDPYNGFTFSVELDGITRAGFRECSGLQNSQNVSTYREGTDRYLSPRKIPGMVTYGDITLSRGITSDTKLWEWRLKTVRGDVQRHNISVSVLDDAGTAKITWNLFDAWPTSWTGPSFNATSDEFAIEQITIAYERLEVGQWS
>NC_014666|8608247:8621090|8611455_8611791_+|WP_041262193.1|DBSCAN-SWA
MPRGLLGPDGAVHRTGTMRLATAYDEIEPLKDPRVRANPGYLVVILLARVIIRLGTLEHVNTAAIEHLYAADLAYLQDLYQRINLTGSTRLAVACPHCAGDFEVETSGLGG
>NC_014666|8608247:8621090|8614007_8614772_+|WP_013428129.1|DBSCAN-SWA
MTLINPPAGGPRGDSLEKLTIFYRKDGVEPTFVEALFNPAEISRSRTIEWEKPVAGLIAKVPYQPRRDFVAVRPETLSVSLFFDTCESRADADSRVAGLLTNLAAPGSPFDSGTASDVTRLTRRVVELAQVDRETHEPPVCQLSWGRYAHIFTGVLTQLDQRFTMFLPDGTPVRATLDCTFAESPTLAAARAGELHSADVVKSRVVRRGDTLHSIAAREYGDPALWKEIARANGITNPLRVSPGTVLTIPRLDG
>NC_014666|8608247:8621090|8614781_8615849_+|WP_013428130.1|DBSCAN-SWA
MPSATSGIPALPTPTVRLDGAQLPPEVQRDLIAIRIEQDLGAIGMLTLELRNWDAATQRHTWSDSSLLAVGTGIEVWLGGPGAPSAFLGEVTGIEPVWAPDRSPTVTVRAYDYLHRLTRGSVTRTFVDASDSDIASRLAREAGLRARVTATGTRHRHVLQSNQTDLEFLRSRARRHGFEVFVRDRELHFREPALGAPVTSVLRVGDEIEHFVAWLSAAGRAGRETVRAWDPRAKEAVVGSGESQVLPAMGGAGVGQRQTDTIFGRATVTTADVPVRTRREAEELALGRLRTSALTYVEAEAEGGDALAPVRAGTTVGVQGAGTRFSGTYYVAQVVHTFAYDNRFRSSCQLRRTSA

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013428122.1|8608247_8609669_+|tail	phage tail sheath family protein	J9PVC2	Bacillus_phage	1.7e-40	28.7
WP_157735214.1|8609677_8610868_+|tail	phage tail sheath family protein	NA	NA	NA	NA
WP_013428124.1|8610892_8611333_+|tail	phage tail protein	NA	NA	NA	NA
WP_041262193.1|8611455_8611791_+	hypothetical protein	NA	NA	NA	NA
WP_157735630.1|8612218_8612719_+|tail	phage tail protein	A0A059XP41	uncultured_phage	2.1e-09	33.3
WP_013428128.1|8612715_8614011_+	hypothetical protein	NA	NA	NA	NA
WP_013428129.1|8614007_8614772_+	LysM peptidoglycan-binding domain-containing protein	NA	NA	NA	NA
WP_013428130.1|8614781_8615849_+	phage late control D family protein	NA	NA	NA	NA
WP_013428131.1|8615845_8616490_+|tail	phage tail protein	NA	NA	NA	NA
WP_013428132.1|8616520_8616907_+	PAAR repeat-containing protein	NA	NA	NA	NA
WP_041259842.1|8616921_8617329_+	GPW/gp25 family protein	I3WW67	Acinetobacter_phage	9.8e-05	37.5
WP_013428134.1|8617406_8621090_+|plate	putative baseplate assembly protein	A0A1J0GW37	Streptomyces_phage	7.1e-09	30.8