CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_014654	Halanaerobium hydrogeniformans, complete sequence	5 crisprs	csa3,cas14k,RT,WYL,cas4,cas3,DinG,DEDDh,cas6,cas2,cas1,cas5,cas7,cas8b1	0	4	12	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_014654_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014654_1

9304-9387

Orphan

Consensus_repeat	Method
TTGTTCTATTAAAGAAGATCAGTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014654_1

>merge|NC_014654|1|9304-9387|CRISPRCasFinder
TTGTTCTATTAAAGAAGATCAGTGCGACGGACTCAATGTCCAAGTGCTGAATCATCCTTTTTGTTCTATTAAAGAAGATTCAGT

>NC_014654|1|1|9304-9387|CRISPRCasFinder
TTGTTCTATTAAAGAAGATCAGTG	CGACGGACTCAATGTCCAAGTGCTGAATCATCCTTT
TTGTTCTATTAAAGAAGATTCAGT

Protein	Signature genes	Signature genes Name	Protein_function
NC_014654.1\|WP_013404610.1\|3110_4232_+\|DNA-replication/repair-protein-RecF	unknown	unknown	gnl\|CDD\|234608
NC_014654.1\|WP_013404608.1\|1759_2875_+\|DNA-polymerase-III-subunit-beta	unknown	unknown	gnl\|CDD\|235541
NC_014654.1\|WP_013404609.1\|2888_3107_+\|RNA-binding-S4-domain-containing-protein	unknown	unknown	gnl\|CDD\|379097
NC_014654.1\|WP_013404623.1\|24166_24928_+\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NC_014654.1\|WP_013404614.1\|15338_16214_+\|hypothetical-protein	unknown	unknown	unknown
NC_014654.1\|WP_013404622.1\|23607_24000_+\|PTS-dependent-dihydroxyacetone-kinase-phosphotransferase-subunit-DhaM	unknown	unknown	gnl\|CDD\|131417
NC_014654.1\|WP_013404617.1\|19447_20728_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|369639
NC_014654.1\|WP_013404621.1\|22950_23580_+\|dihydroxyacetone-kinase-subunit-L	unknown	unknown	gnl\|CDD\|274099
NC_014654.1\|WP_013404615.1\|16341_17838_+\|glycerol-kinase-GlpK	unknown	unknown	gnl\|CDD\|234594
NC_014654.1\|WP_013404618.1\|20728_21106_+\|DUF1667-domain-containing-protein	unknown	unknown	gnl\|CDD\|377938
NC_014654.1\|WP_013404620.1\|21922_22915_+\|dihydroxyacetone-kinase-subunit-DhaK	unknown	unknown	gnl\|CDD\|237724
NC_014654.1\|WP_013404612.1\|4500_6423_+\|DNA-topoisomerase-(ATP-hydrolyzing)-subunit-B	unknown	unknown	gnl\|CDD\|235542
NC_014654.1\|WP_013404607.1\|76_1498_+\|chromosomal-replication-initiator-protein-DnaA	unknown	unknown	gnl\|CDD\|273037
NC_014654.1\|WP_013404616.1\|17976_19455_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223652
NC_014654.1\|WP_013404611.1\|4240_4501_+\|DUF370-domain-containing-protein	unknown	unknown	gnl\|CDD\|377201
NC_014654.1\|WP_013404613.1\|6455_8954_+\|DNA-gyrase-subunit-A	unknown	unknown	gnl\|CDD\|235502
NC_014654.1\|WP_013404619.1\|21109_21631_+\|type-1-glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|153228

Protein	Function_ID	Function_description	E-value
NC_014654.1\|WP_013404610.1\|3110_4232_+\|DNA-replication/repair-protein-RecF	gnl\|CDD\|234608	PRK00064, recF, recombination protein F; Reviewed.	5.24197e-133
NC_014654.1\|WP_013404608.1\|1759_2875_+\|DNA-polymerase-III-subunit-beta	gnl\|CDD\|235541	PRK05643, PRK05643, DNA polymerase III subunit beta; Validated.	1.03977e-122
NC_014654.1\|WP_013404609.1\|2888_3107_+\|RNA-binding-S4-domain-containing-protein	gnl\|CDD\|379097	pfam13275, S4_2, S4 domain. The S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4.	1.43386e-26
NC_014654.1\|WP_013404623.1\|24166_24928_+\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	3.65642e-85
NC_014654.1\|WP_013404622.1\|23607_24000_+\|PTS-dependent-dihydroxyacetone-kinase-phosphotransferase-subunit-DhaM	gnl\|CDD\|131417	TIGR02364, dha_pts, dihydroxyacetone kinase, phosphotransfer subunit. In E. coli and many other bacteria, unlike the yeasts and a few bacteria such as Citrobacter freundii, the dihydroxyacetone kinase (also called glycerone kinase) transfers a phosphate from a phosphoprotein rather than from ATP and contains multiple subunits. This protein, which resembles proteins of PTS transport systems, is found with its gene adjacent to.	2.22577e-37
NC_014654.1\|WP_013404617.1\|19447_20728_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|369639	pfam07992, Pyr_redox_2, Pyridine nucleotide-disulphide oxidoreductase. This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.	1.76003e-27
NC_014654.1\|WP_013404621.1\|22950_23580_+\|dihydroxyacetone-kinase-subunit-L	gnl\|CDD\|274099	TIGR02365, dha_L_ycgS, dihydroxyacetone kinase, phosphoprotein-dependent, L subunit. Two types of dihydroxyacetone kinase (glycerone kinase) are described. In yeast and a few bacteria, e.g. Citrobacter freundii, the enzyme is a single chain that uses ATP as phosphoryl donor and is designated EC 2.7.1.29. By contract, E. coli and many other bacterial species have a multisubunit form (EC 2.7.1.-) with a phosphoprotein donor related to PTS transport proteins. This family represents the subunit homologous to the E. coli YcgS subunit.	1.9892e-90
NC_014654.1\|WP_013404615.1\|16341_17838_+\|glycerol-kinase-GlpK	gnl\|CDD\|234594	PRK00047, glpK, glycerol kinase GlpK.	0
NC_014654.1\|WP_013404607.1\|76_1498_+\|chromosomal-replication-initiator-protein-DnaA	gnl\|CDD\|273037	TIGR00362, DnaA, chromosomal replication initiator protein DnaA. DnaA is involved in DNA biosynthesis; initiation of chromosome replication and can also be transcription regulator. The C-terminal of the family hits the pfam bacterial DnaA (bac_dnaA) domain family. For a review, see Kaguni (2006). [DNA metabolism, DNA replication, recombination, and repair].	0
NC_014654.1\|WP_013404620.1\|21922_22915_+\|dihydroxyacetone-kinase-subunit-DhaK	gnl\|CDD\|237724	PRK14481, PRK14481, dihydroxyacetone kinase subunit DhaK; Provisional.	0
NC_014654.1\|WP_013404612.1\|4500_6423_+\|DNA-topoisomerase-(ATP-hydrolyzing)-subunit-B	gnl\|CDD\|235542	PRK05644, gyrB, DNA gyrase subunit B; Validated.	0
NC_014654.1\|WP_013404618.1\|20728_21106_+\|DUF1667-domain-containing-protein	gnl\|CDD\|377938	pfam07892, DUF1667, Protein of unknown function (DUF1667). Hypothetical archaeal and bacterial proteins make up this family. A few proteins are annotated as being potential metal-binding proteins, and in fact the members of this family have four highly conserved cysteine residues, but no further literature evidence was found in this regard.	1.18276e-36
NC_014654.1\|WP_013404616.1\|17976_19455_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|223652	COG0579, COG0579, Predicted dehydrogenase [General function prediction only].	2.5269e-113
NC_014654.1\|WP_013404611.1\|4240_4501_+\|DUF370-domain-containing-protein	gnl\|CDD\|377201	pfam04025, DUF370, Domain of unknown function (DUF370). Bacterial domain of unknown function.	2.17642e-11
NC_014654.1\|WP_013404613.1\|6455_8954_+\|DNA-gyrase-subunit-A	gnl\|CDD\|235502	PRK05560, PRK05560, DNA gyrase subunit A; Validated.	0
NC_014654.1\|WP_013404619.1\|21109_21631_+\|type-1-glutamine-amidotransferase	gnl\|CDD\|153228	cd03134, GATase1_PfpI_like, A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus. A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus. This group includes proteins similar to PfpI from P. furiosus. and PH1704 from Pyrococcus horikoshii. These enzymes are ATP-independent intracellular proteases and may hydrolyze small peptides to provide a nutritional source. Only Cys of the catalytic triad typical of GATase1 domains is conserved in this group. This Cys residue is found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow. For PH1704, it is believed that this Cys together with a different His in one monomer and Glu (from an adjacent monomer) forms a different catalytic triad from the typical GATase1domain. PfpI is homooligomeric. Protease activity is only found for oligomeric forms of PH1704.	5.21255e-63

>NC_014654.1|WP_013404613.1|6455_8954_+|DNA-gyrase-subunit-A
MNQKAARVEKIDIDKEMRGSYLDYAMSVIVGRALPDVRDGLKPVHRRILYALNDLGMTPNKPHKKSARIVGEVLGKYHPHGDTAVYDTMVRMAQDFSYRYPLIDGHGNFGSVDGDSAAAMRYTEARMSSITTELLTDINKETVDFTPNFDESLEEPQVLPARFPNLLVNGSAGIAVGMSTSIPPHNLGEVIDGVVKLITKPEITTKELMTIIKGPDFPTGGQIMGRGSIYKAYKTGRGKLTVRAKTRIEDLKVNRKQIIVDELPFQVNKARLIKKIANLVKDEKIDAISDIRDESDRDGMRIVIELKREATPEVVLNQLYKHSRLQITFSTIMIALVNNEPKVLSLKEILEHYLEHQKKVITRRTKYDLDKALDRAHILEGYKIALANIDEIVEMIKEAEDVDTARIALMDDYELSEIQANAILRMRLQSLTGLERNKIDTEYDELQAKITRYRSILADEDKLLNIVKKEILEIKDKYNDKRRTKIMDKVTDLEIEDLIEEEQIVITMTHQGYIKRMALDLYRSQRRGGKGVIGISTKEEDFVENIFTTTTHHKFLFFSNQGRVYRLKGYQIPEAGRQARGTAIINLLELKEEERITAVIPVKEFPEDAYLIMATKNGLIKKTSLDAYDTNYTGLIGINLRENDELIGVRIIDEDENIILVSKNAKAIHFNESDVRSVGRNSYGVRGIRLSEEDYVIDMGIDSAGEHLLVITENGYGKKTPLTEYRIQNRGGKGILTANITEKNGQLAAAKIVDANSEMMVITHEGIIIRVQAEEISTTGRNTIGVKIINVEEDDKVVSLARINEDEIVDELEELDKIETETDDLDKLYEEE
>NC_014654.1|WP_013404612.1|4500_6423_+|DNA-topoisomerase-(ATP-hydrolyzing)-subunit-B
MDFKERSNYEAEHIQVLEGLEAVRKRPGMYIGSTSTEGLHHLVYEVVDNSIDEAMAGYCTEIIVEIQPGNIIKVKDNGRGIPVENHPKIDKPAVEVVMTTLHAGGKFGGEGYKVSGGLHGVGISVVNALTEWMEVEIAWKDGKVYKQKYERGVPQHELRAIGSCDSDCTGTTIEFKADPQIFEEIDYEYRNLAQRLKELAFLNKGLKIKIIDSRVDETKEDEYQYDGGLVSFVKYLNQSKKPLYPDPIYLETEGEEGSLEVAIQYHQGYNSSIFSFANNINTKEGGTHLSGFKSAITRTFNDYARKKNILKDSDDNFKGQDIREGMTAIISVKLADPQFEGQTKTKLGNSEMRGFVDSAVSSFLKTFLEENPKIAKVIVDKALSAARARKAARKARDLTRRKSALTSTALPGKLADCAKRQAKDTEVYIVEGDSAGGSAKQGRNREFQAILPLKGKILNVEKSRLNKILNNDEIRALITAIGTGVAEEFDINNLRYERIIIMTDADIDGAHIRTLLLTFFYRYMRPLLENGNIYIAQPPLYKVKKGRKEEYVYNDKALKELLDEIGRDRVSMQRYKGLGEMNPGQLWDTTMDPDNRILLQVNIEDAILADETFSILMGDKVEPRRKFIQENAAQVKNLDV
>NC_014654.1|WP_013404611.1|4240_4501_+|DUF370-domain-containing-protein
MFLHLGGGNMIPSDQVVLIGDLENTTYSEITQEFMQISDEEGFIVDYSAGNPRSFVLTGETIYLSMISSKTLADRVDKFTEENGGY
>NC_014654.1|WP_013404610.1|3110_4232_+|DNA-replication/repair-protein-RecF
MHLKRVLCRNFRNFDEIILDLNSNLNIFLGDNGQGKTNLLEAIYIMATTNSHRSSVCSELINWKKEEALIQLLLERREGNIKLAMRLDKGGRRVELNDNPLDKVKEMVGYLNAVLFSPEDLKLVKEGPSHRREFINLEISQVSRYYNHLLSKYDHILKQRNNLLKSIRDGKKSSENMLSIWDEQLSTIGAKIILKRIEVVDKLKILARLSQRQITEGKEELEIEYDISLDGFSEKMGEAELRGLFNKNLKEKREQEINRGYTVIGPHRDDLILKINEMDLRKYGSQGQQRTAALALKLAELEFMKSETGEYPVLLLDDVFSELDSLRRKALINIIANKIQTIITATDGENLSGLKNNSYHVYRVKEGKIKKRG
>NC_014654.1|WP_013404609.1|2888_3107_+|RNA-binding-S4-domain-containing-protein
MEKIEINTDTINLDQFLKWANIAMSGGEAKYLIQEGEVTVNGEVETQRGKTLKVGDVVSLTGNDKKYIVSRG
>NC_014654.1|WP_013404608.1|1759_2875_+|DNA-polymerase-III-subunit-beta
MKFSIEQKDLYKALNIVRRAVAKNKTLPILTGIYLKVEKNILSLKATDLELGIKYNVNVDSEEEGSVVLPAMQFINIIRELPSEKIEIELNEDKWQLQINCLNSLFKINGFDPDEFPSLPEVEASAEFNLPAAKFKSMLEKVKISTSKDETQPALTGALFVVKAEEVRMVSTNTYRLSYVDSPLKTNLDQIIEVILPGSTLDELNNLLEDEGSIDIVVDNNYARFEFAGIELISRLIEGKFPNYELVIPDEFNSKFKADLSKLHGAVKRASLIAKEDANIISISADEGIMEINSTEGSAGYAHEELSIELSGPDQKINIDAGYLIDVLKVLDSEEINIEMIGPLNPLVIKNEDQAGGKFIYLIMPVRAQAS
>NC_014654.1|WP_013404607.1|76_1498_+|chromosomal-replication-initiator-protein-DnaA
MSFSQKELNHIWEKTLEKIKEKITNPSFNTWFSETKAVLTTKENQLVLQVPNNFIQEWIETQYINLIEDILNDLTGNEWSLLLLTPKEVKKFKEKQAENKKVHSKNNNTDLMDETDDFDDLGEQEDEEKLNNGFNPKYTFDTFVVGNSNRFAHAASLAVAEAPAKAYNPLFIYGDVGLGKTHLMQAIAHFILKNNPDYKVVYVSSETFTNELINSIKDDSTVDFRDKYRNIDILLVDDIQFLAGKERTQEEFFHTFNTLHESNRQLIISSDRPPKEIPTLEERLRSRFEWGLITDIQKPDLETRIAILRKKADIENLTIPNEVVIYIANKIQSNIRELEGALVKVIAYSSLVDREIDIELAREALKDLVNKKKDEHIEVNIERIKKIIIEDYNLRMEDMESKKRTQNIAFPRQIAMYLSRELTDFSLPHIGDEFGGRDHTTVIHAHNKIKEKIKNEEDFSKKIERLTNTIKHG
>NC_014654.1|WP_013404614.1|15338_16214_+|hypothetical-protein
MGITLNLVLAAFGGGLFGSAIGALPAFIFTGFLVLAGEALALAGGAGDFTGVIAFGTLFGPHIAFAGGAAATAYAASKGKLEGGANILKPLMGIRENWDILLVGGAFGVLGLVVNQFLASIGTPSDTIAITVVVSALVHRVAFGETGIFGKYDPEVSDSRWSITPDIAWLPWQMNLSQLIPIGLGTGLVAGFVAIETGTVFIMFGITAASLIILQTMGEGPVTHHIAFPAAAAAMATNSVIWGGIFGVLGAILGEFYARLFYSWGDTHIDPPAATIATLITAAMLFLGFSF
>NC_014654.1|WP_013404615.1|16341_17838_+|glycerol-kinase-GlpK
MENYVLAIDQGTTSSRAMIFDHDGQVVSVAQKEFTQYFPKPGWVEHDPDEIWGTTLGVIADALGKKNIKPSQIISIGITNQRETTVVWDAETGEPIHNAIVWQDRRTASICDDLKDAGHEQTIKDKTGLVVDAYFSGTKIKWMLDNVEGAREKADAGKLRFGTIDTWLIWKLTGGNVHVTDYTNASRTLIYNIKELKWDDELLGFLDVPRSMLPEVKASSEVYGNTVDFHFFGEEVPIAGIAGDQQAATFGQVCYEKGMAKNTYGTGCFMLMNTGEEAVASENGLLTTIAYGIDGKVNYALEGSIFIAGAAIQWLRDELKIIDKAPDSEYFANKVEDTGGVYVVPAFAGLGAPYWDMYARGTIVGLTRGTSKEHLIRATLESIAYQTRDVLEAMEADSGIELKTLRVDGGAAMNDFLMNFQADILGVEVERPKVNETTALGAAYLAGLAVGFWDNKEELVAKWDRDALFVPKMAEEKKEKLYAGWKKAVERAKDWSDE
>NC_014654.1|WP_013404616.1|17976_19455_+|NAD(P)/FAD-dependent-oxidoreductase
MSQNKYDVIIVGGGISGCAVAWKLARYNIDVLLLEKDPDVATGTTKANTAIIHAGYNADPEKQKGRLNNKGNIQIKQIVKDLNIPFEEIGSLVVGMEGDNLSVLDELLEKGKRNGVEGLEIVDKEWLLREEPHINKDVVAALWAPTAGIITPWEFALAMAQNAVANGVDIQLETEVLDVYTDNGKVTGVKTNKGDYQADYVVNAAGLYADDVAKMVGVEKIEIHPRKGEYYIYDHAKDFEINHVLFPIPTKISKGIVCTPTVEDNLLIGPTSDFVDSKEDLATSREGLDHVFEGAKKMFPDLTLQDTIRVFAGLRAADKTEDFVIEAADTVDGFVNVAGIQSPGLSSAPAIADLAAEILEDLGLTLEEKKDVIETREEPVRFYEMSNEERAKYVEKNKKYGKIICRCETVSYKEILDAIHGPVGARTVNAVKRRTRAGAGRCQGGFCGPRVTQILADELGIDTTEVRLEKNNSKIVEHKIKGLLGSKVIDNA
>NC_014654.1|WP_013404617.1|19447_20728_+|FAD-dependent-oxidoreductase
MLKVKKDVVVIGGGPAGLAAAAEVYDNGVEDVIILERDFELGGILPQCIHNGFGLHYFKEELTGPEYSQRFENDVEERDIEVKLNTMVLDVTPDRKVYAMNQEEGFLEIEAGAVILAMGCRERTAGALGIPGTRPAGVLTAGTAQRFTNIEGYVPGEEVVILGSGDIGLIMARRMRLEGADVKAVCEILPYTGGLTRNVVQCLEDYDIPLLLNHTVTKIIGNDRLEAVEITEVDENMKPKPETSKIIKADTLLLSVGLIPENELSKKADVVLDDTTGGPFVNEGRETNIEGIFACGNVLHVHDLVDWVTQESQIAGNWAAKYVKGEYKRTDSKIKMKAGENVSYVIPHTVELDGSDRNRIPLYMRVSTPLMAVDINLYADGEKLYSFSEPFAKPGEMITVPLAQKTLDDLDDVKEIRVDIIEKEGQ
>NC_014654.1|WP_013404618.1|20728_21106_+|DUF1667-domain-containing-protein
MKETKTLTCVACPKGCEVTVEFEGDEILNIDGHACPQGKTYAEEEIVAPTRILPTTVKVKNGALPLCPVKTTKQIPLEIIHDAMAIIGQKEVEAPIEIGQIIIENILDSGADIVATRDLPKKIEV
>NC_014654.1|WP_013404619.1|21109_21631_+|type-1-glutamine-amidotransferase
MKLKDKKIAMLIGPGYEDLEFWVVYMRMIEEGAEVDVVGVEKGVEYSSKHGCLKKAADYTAGEVLDNDYDGVLVPGGWTPDKIRRDADVVELVRKNHDAGKIIGLICHAGLVGISAGIVDSKATGSLGIKDDCINAGAEWVDEAAFRDGDIVWGRVVKDIPAYCRELVAALAD
>NC_014654.1|WP_013404620.1|21922_22915_+|dihydroxyacetone-kinase-subunit-DhaK
MKKKLVNNPDHVVEEMVEGIVLAAPDKLTKIEGYNVVVRKDSPNEKVALVSGGGSGHEPTHAGFVGEGMLDGAIAGDVFTSPTPDAVFEAIKAVDGGKGVLLVVKNYTGDVMNFEMAAEMAEAEGIEVDHVVVDDDVAVEDSLYTTGRRGVAGTIFVHKIAGAKAEAGADLAEVKEVAEKVIENVKTKGMALYPCRVPSADESTFTLDEDEIELGIGIHGEPGTERTEIMKADDIVDELLGSVIEDIPYQSGDDVALMINGMGGTPLMELFVANRRANQILEEKGINIYKTFVGEYMTSLEMAGLSITLLKLDDEMKELLDAPTEINIMK
>NC_014654.1|WP_013404621.1|22950_23580_+|dihydroxyacetone-kinase-subunit-L
MTEKSKEILDKIADVIIENKKHLTKLDSAIGDGDHGINMARGFKEVKEKINGNNFETNQELLKSVAMTLISTVGGASGPLYGTAFLYISKVIPDADFTVDSLIEIGQSAVDGIQKRGKAEQGEKTMLDAIIPAVDALKESKENGDDLEEALQKCKAKAEEGMKATIPMQATKGRASYLGERSIGHQDPGATSSYLMIKTVVDELYKYKD
>NC_014654.1|WP_013404622.1|23607_24000_+|PTS-dependent-dihydroxyacetone-kinase-phosphotransferase-subunit-DhaM
MVNILLVSHSVEIAKGTKELAEQMKQGDVEIVAVGGTEAGDLGTNPDAIESAVNEIDKSDGLIILADLGSAVMSVNMVLDWLDDEVREKIHLADAPFVEGAVIAAVESGMGNSMEEILSSIESAEIIKKN
>NC_014654.1|WP_013404623.1|24166_24928_+|DeoR/GlpR-transcriptional-regulator
MFAEERRKEIIKTLENSKRASVNELSEEFDVSRATIRRDLSELEKEGFLRRTHGGAILSGSSKLEPSYKEKEDHFASEKAAIGKKAAEIIKDGDTIYIDAGTTTRNIIDHLKGKNNLTIVSNAHHIIKRVKDSEIDCELVVVGGSFKKTTEAMIGPMAEDFLEKLRVDKAFIGVNGFNLEAGATTPDPKEAKIKEIAVSIAAENFFLFDRSKWEEVYFCRFADLNMIDFIITDQLAREKEKALKEKNIQIIKA

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Crispr_ID: NC_014654_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014654_2

594431-594556

Orphan

Consensus_repeat	Method
ATGGGACAATCGAGAATATCTCTATAAAAGATGTAGATATAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014654_2

>merge|NC_014654|2|594431-594556|CRISPRCasFinder
ATGGGACAATCGAGAATATCTCTATAAAAGATGTAGATATAACAGGTGATAAATTTGTTGGTGGTCTGGTTGGATATAATCATAATGGGACAATCGAGAATATCTCTATAAAAGATGTAGATATAA

>NC_014654|2|2|594431-594556|CRISPRCasFinder
ATGGGACAATCGAGAATATCTCTATAAAAGATGTAGATATAA	CAGGTGATAAATTTGTTGGTGGTCTGGTTGGATATAATCATA
ATGGGACAATCGAGAATATCTCTATAAAAGATGTAGATATAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_014654.1\|WP_013405089.1\|605497_606232_+\|basic-amino-acid-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270342
NC_014654.1\|WP_013405090.1\|606395_607085_+\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836
NC_014654.1\|WP_160143091.1\|610540_611827_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|349949
NC_014654.1\|WP_013405075.1\|579060_579639_+\|hypothetical-protein	unknown	unknown	unknown
NC_014654.1\|WP_013405078.1\|582946_584134_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|273540
NC_014654.1\|WP_160143046.1\|587784_589629_+\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|225116
NC_014654.1\|WP_013405080.1\|585426_587028_+\|UDP-glucose--hexose-1-phosphate-uridylyltransferase	unknown	unknown	gnl\|CDD\|235382
NC_014654.1\|WP_013405079.1\|584330_585323_+\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NC_014654.1\|WP_013405076.1\|579823_580885_+\|SARP-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|226456
NC_014654.1\|WP_041595759.1\|608775_610293_+\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223354
NC_014654.1\|WP_049773822.1\|589707_590664_-\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|225116
NC_014654.1\|WP_041595758.1\|597538_597724_-\|nucleotidyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|376187
NC_014654.1\|WP_013405086.1\|597889_599038_+\|glycerate-kinase	unknown	unknown	gnl\|CDD\|376844
NC_014654.1\|WP_013405088.1\|603850_605317_+\|glutamate-synthase-subunit-beta	unknown	unknown	gnl\|CDD\|237213
NC_014654.1\|WP_013405087.1\|599236_603829_+\|glutamate-synthase-large-subunit	unknown	unknown	gnl\|CDD\|236968
NC_014654.1\|WP_013405084.1\|590828_592034_-\|PAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|369881
NC_014654.1\|WP_013405077.1\|581077_582928_+\|excinuclease-ABC-subunit-UvrC	unknown	unknown	gnl\|CDD\|234792
NC_014654.1\|WP_013405081.1\|587051_587738_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NC_014654.1\|WP_013405092.1\|607832_608495_+\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836
NC_014654.1\|WP_013405091.1\|607074_607833_+\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051

Protein	Function_ID	Function_description	E-value
NC_014654.1\|WP_013405089.1\|605497_606232_+\|basic-amino-acid-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270342	cd13624, PBP2_Arg_Lys_His, Substrate binding domain of the arginine-, lysine-, histidine-binding protein ArtJ; the type 2 periplasmic binding protein fold. This group includes the periplasmic substrate-binding protein ArtJ of the ATP-binding cassette (ABC) transport system from the thermophilic bacterium Geobacillus stearothermophilus, which is specific for arginine, lysine, and histidine. ArtJ belongs to the type 2 periplasmic-binding fold protein (PBP2) superfamily, whose members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. PBP2 typically comprises of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.40833e-98
NC_014654.1\|WP_013405090.1\|606395_607085_+\|amino-acid-ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	5.62454e-61
NC_014654.1\|WP_160143091.1\|610540_611827_+\|MFS-transporter	gnl\|CDD\|349949	cd06174, MFS, Major Facilitator Superfamily. The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.	2.38186e-19
NC_014654.1\|WP_013405078.1\|582946_584134_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	1.26805e-102
NC_014654.1\|WP_160143046.1\|587784_589629_+\|PAS-domain-S-box-protein	gnl\|CDD\|225116	COG2206, COG2206, c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms].	8.12938e-57
NC_014654.1\|WP_013405080.1\|585426_587028_+\|UDP-glucose--hexose-1-phosphate-uridylyltransferase	gnl\|CDD\|235382	PRK05270, PRK05270, UDP-glucose--hexose-1-phosphate uridylyltransferase.	0
NC_014654.1\|WP_013405079.1\|584330_585323_+\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	6.87203e-79
NC_014654.1\|WP_013405076.1\|579823_580885_+\|SARP-family-transcriptional-regulator	gnl\|CDD\|226456	COG3947, COG3947, Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms].	4.01088e-25
NC_014654.1\|WP_041595759.1\|608775_610293_+\|FAD-binding-oxidoreductase	gnl\|CDD\|223354	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion].	1.73967e-66
NC_014654.1\|WP_049773822.1\|589707_590664_-\|diguanylate-cyclase	gnl\|CDD\|225116	COG2206, COG2206, c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms].	1.88643e-57
NC_014654.1\|WP_041595758.1\|597538_597724_-\|nucleotidyltransferase-domain-containing-protein	gnl\|CDD\|376187	pfam18765, Polbeta, Polymerase beta, Nucleotidyltransferase. A member of the nucleotidyltransferase fold found in polymorphic toxins (NTox45) and polyvalent proteins.	7.61386e-12
NC_014654.1\|WP_013405086.1\|597889_599038_+\|glycerate-kinase	gnl\|CDD\|376844	pfam02595, Gly_kinase, Glycerate kinase family. This is family of Glycerate kinases.	0
NC_014654.1\|WP_013405088.1\|603850_605317_+\|glutamate-synthase-subunit-beta	gnl\|CDD\|237213	PRK12810, gltD, glutamate synthase subunit beta; Reviewed.	0
NC_014654.1\|WP_013405087.1\|599236_603829_+\|glutamate-synthase-large-subunit	gnl\|CDD\|236968	PRK11750, gltB, glutamate synthase subunit alpha; Provisional.	0
NC_014654.1\|WP_013405084.1\|590828_592034_-\|PAS-domain-containing-protein	gnl\|CDD\|369881	pfam08447, PAS_3, PAS fold. The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.	4.62384e-23
NC_014654.1\|WP_013405077.1\|581077_582928_+\|excinuclease-ABC-subunit-UvrC	gnl\|CDD\|234792	PRK00558, uvrC, excinuclease ABC subunit UvrC.	0
NC_014654.1\|WP_013405081.1\|587051_587738_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	3.78501e-48
NC_014654.1\|WP_013405092.1\|607832_608495_+\|amino-acid-ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	1.47313e-71
NC_014654.1\|WP_013405091.1\|607074_607833_+\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	1.05906e-135

>NC_014654.1|WP_013405084.1|590828_592034_-|PAS-domain-containing-protein
MKSNLNTNLFDEENCKKLFTKNKKLALIIIQFNKKTKQAYIKFLSRGAEKLLGYQSTELIDKNFAVILNKNQTNIISDIVNKALKNELKYEDIEIINKNRQKIKAELEIYPFKLKQKSKENLSFALNILDPDQCTEKLKSILNNVKNAIWSASWPDYKTYYISPSIKDIYGYEAEDFKNNFKLWYECVHPDDRNKIKETYNDLHKTGFSQKEMRIIKKSGEIIWVEDQNRFIYNENNNPIRIEGIVQDITERKKSDEKLEFQFDFQKLIADISSNFVKLDSDQFDEAVDYALKKVGSFFEIDRSYLFLTSEDGSNSSNTHEWCRDGIEPKIDELQDLDNDSFPWFRDNLVNNHYVYIADTDQLSEDAANKKKSLKDQKIKSLVAVAIFNKDELKGFLALNR
>NC_014654.1|WP_049773822.1|589707_590664_-|diguanylate-cyclase
MKKLDKKENLPIGIIMTDINGLKLINNSYGQQIGDQIIIKSAELLKTTLKSNDIIGRWGGDEFIIIMINTHKQEVELYTREIKNLINIEPQSKIDISLSAGSALKITAEEKILNLIQQAEQALFTDQLTKEKSSKNKIVQSLLSTLRNKSNETEHHSVRMAELAQELGRAVGVGNNDLNKLALLANIHDIGKITIPESILNKPGKPDKEEWEILKKHPIKGAEIASETDEFAPVAEEILSHHEHFDVSGYPRGLKGKEIPLLARILTIVDAYDVMINERPYKKAMTKKEADLELQRCAGSQFDPELVDKFFKIIESDL
>NC_014654.1|WP_160143046.1|587784_589629_+|PAS-domain-S-box-protein
MIILFKKEKKIIFVYLIIGISWVYFSQRYLPLFSDNFEQYNQLQSYNFLIFVLLSSLFSFLFLKKYLAMIRDNNRLLKLKEKDLRDLKEQKQQLNNNLEQADQKIKSKNQRFVKMIAAVSALNDNPEEVEEDFLTKILSSAVHIIPEADYGKIYIFEGEKCKFVSAVGHDFEILRKTDINKIFVCDLSDYNSKCIRDYTIKLEKLPKKQREEIIRALRPIKESIYNEIKVKGKVIGRISLDIAEESDQNFSNLSSIILESFAALASSHFAYKKYDKLQAKFTKELINSIIKILEMYDMYTKGHSEHVANLSLLLAEEMELSDKNVMDAYWAGMVHDIGKLLIPINILNKKNRLTDVEYDLIKRHPLWGSKSLSDSDALKNIARYIHYHHERWDGKGYPNGLERNEIPVISQILSVSDTWDAMTSDRSYRKSLTKKEALEEIKENRGSQFSPVVVDAFVHIMEKRKLNIEQKVKEKFNQLESKAVIGSENKLFENLFERSRQGIIILDEEFNVEKVNPYFLNVFGFQRNDVLGINIKDFLLPREKRAESEKNIEALKAGREINVKTYRQKKSGEKIEVEIQAFPVGESENEINYCFIYRDICEAGLKRNLYNYQM
>NC_014654.1|WP_013405081.1|587051_587738_+|GntR-family-transcriptional-regulator
MSKFNLSAIDSYSYEPLRKQVYNVLREAILKGELMIGEKITEMEIADELSVSRTPVREAFRMLEQEELINIIPQQGVFVAGIETKKEIDDIFQLRAELEGLAAYLAAQNITEKQKEKLKEYTEELKDHIAHNDYRGCIKVDIAFHRIIKEASDNKWLEKFLDTLFEQATRFRRSSFSRQGRLQEFLQEHQELGEAIINGDPDKARESAEGHIRAAWDSIITVFEKEQR
>NC_014654.1|WP_013405080.1|585426_587028_+|UDP-glucose--hexose-1-phosphate-uridylyltransferase
MQVAKANQLIEKLLAYGEKNNLLVEWDKIAARNEIRDILEIKEAPAEALDSESELELADNPQPILDGLLDFAVAKSLINDNLTERDLLDTRIMGALTPRQSEIAKRFYETAEEVDVKAAAEQYYNFAQKSNYIRLKRTSKNLNWKAESDYGQIEITINLSKPEKDPAEIARAKAEPQSNYPKCYLCLENVGYAGSLNHPARQNHRVIPLKLQNEDWFLQYSPYVYYNEHCIVFHREHKPMNINKNTFAVLMDFLDQIPHYFIGSNADLPLVGGSILNHDHFQGGRHIFPMEEAESVAYYEHPTFMDIEISRLKWPLSVIRLRSAERGELINLADKILQNWREYTDHGLKIKAYSKEEGKKTAHNTVTPIARKRKYGSEEQAEQYELDLVLRNNRCSEEYPYGIFHPHQKLHHIKKENIGLIEVMGRAILPGRLKKELNLIAEYLSAKLSLEELKAAEGMAKHLEWVEELESTYGNELQFEQAEKILEKETAKKFSQVLERAGVFKNDIVGVKGFERFLKSIGIKRLEDGNSEL
>NC_014654.1|WP_013405079.1|584330_585323_+|Gfo/Idh/MocA-family-oxidoreductase
MTKVKWGILGCANIARKATIPAILAADNSELYAVASRSKKKAESFAKEFGAEKYYDDYQKLLEDQNIEAVYIPLPNKLHKEWTIKAAEAGKNILCEKPLSGSSKKEAEAMLKAAQENDVLLMEGFMYRFQPFVIKLKEMVDKGVIGEIKEIKANFAFDVSDRGQDLRLNAELDGGALNDIGCYTVNIARYLMGENPTKVANFFEKESADGVDLSGSATLYFAGGSFASLYYSIMSYEEKDIEIIGTRGIIKVPGFFAWKDDNYFLVEQEGHKQKMPVETGEQYRLEVEAFADAILNQKEVPLSVEEESFANLEVVEAMRKSAAEDVIVRL
>NC_014654.1|WP_013405078.1|582946_584134_+|FAD-dependent-oxidoreductase
MNKSDIEIYTKQWCPYCRRAKAMLRSLELEYIDYDITDDKELYEEMVERSGHKTIPQIFIDGENIGGYDALIEKISSGELDYLIDFEIPECEGNVWDLTVIGAGPAGMTAAIYAVRKGLKVLLVARDIGGQVLETDIIDNYPPEYNVSGPDLMQDFLDHLRNYKIDTLFGEEVIEIKVKEAGHQIIVKSGKKINTDAVIISAGTKKRHLGIPGESQLKDKGVSYCATCDGFLYEGQPVAVVGGGNSGLEAALDMARIAEKVYLLVRSERLSGDQTLQDKVMNSDKIEICWSYQAIKINGDTKVESLLIKNLNTGKQRKLNVDAVFIEIGLLPNSGFICEDLKINDYNEVMIDQNNQTSVEGIYAAGDITDIKDKQIIVAAAEGAKAALRVNEYLS
>NC_014654.1|WP_013405077.1|581077_582928_+|excinuclease-ABC-subunit-UvrC
MTDNKITNAQIEAQIKELPAQPGVYMMKDETGMIIYVGKAKSLRSRVRSYFRKNNQSYKTQLLVRYIYDFDYIITDTEVEAYILEANLIKKHQPKFNIRLKDDKTYPFIKVTKNLDFPRVFKTRLVKNDGAEYFGPFADVDAIYKTLDVIKDIFQLRSCKKEIIAGEPEAKPCLNYHINKCLGPCIGAVSKEDYHELIDQVMLFLSGRQEELKAEVEKMMENAAQERNYEKAARFRDALKAFAKLSESQKVMSDKNIDQDVVALVEGENDLACSQLLLVRNGRLIGQEYFILEGTEEENKAEMMGSFLQQYYEQAAGIPDELLLNTDLAYRKLIEERLAVLKGKKVKILQPQKGDKKKMLEMAERNAAQNLKKEDIRSKYEKQRTSGAVKKLAEILEIEKEPHHIEGFDISNIQGTDTVASMVVFKNGRPSKKDYRRFKINTVEGPDDFSSMKEVVERRYARLLREDKKLPDLILIDGGKGQLSAAYEVLELLGIDDLAIIGLAKKEEEIFKPGQSEAIIIPHHSPALQLLQRVRDEAHRFAVSYHRKLRSRRLTHSMLDEIPGVGETRRNALLQHFGSLAKIREAKIWQLKEVEGISSKTARKIFDYLRENMRAF
>NC_014654.1|WP_013405076.1|579823_580885_+|SARP-family-transcriptional-regulator
MNSVVYMGDRENDDILNVLSSDTKNLEISDVFYSAEILLDFLREDEEKIDIIFLDIDKNEDDIFTLVEKLLKLSPEFNFVFMISKNHDFLEILQNKELFYLLKPISAADLKVVIEKVRKEKQSVGSLTELYIETQGDIRIYDVDRNKLNINWPDSKTKELFAFLLHHKGEFVSRDKIIEKLWGANDNKNFRILFFSTLLKLRKIFSQYGFDNLIEANLTAYRISLKRIEVDFIKIEILLKKSITNKYRVYKLLNLLKGSYLAADNFDWCKEYRKEFEKRIKKELNHAAEYFMSVGQNTITKNILTTLINIGVVDESVYDKLINIYKRECNNEKAEQLLKELDNISKEELASII
>NC_014654.1|WP_013405075.1|579060_579639_+|hypothetical-protein
MDLYDIFISNSKVDFIKKVGLEDWWESAFTPKERKYIRSRNKDLFTLENYDDVLNFLYLLASNLFTKNTEKHRRLAFIILKKAVNSTEDQLKLFDLYNLIIYMLDKYQDPSFYSSERLSDYCQKQIEISEKVLKIIKEEDEESVKLFNHHGYKILAKMKLKQGKTAEALSIAKTAKSQNWSGEWDKIICCIE
>NC_014654.1|WP_041595758.1|597538_597724_-|nucleotidyltransferase-domain-containing-protein
MNIEKLKEILLKRKEIIFAYLFGSFAENKENSLSDIDLAVYIDQSEPLHLNQNQDLHQKRY
>NC_014654.1|WP_013405086.1|597889_599038_+|glycerate-kinase
MKILVAPDSFKGSLTALEAAENIKKGIKNFDAQIEVDLLPLADGGEGTVQSLVDAADGEIIKKKVTGPLGEKVEAFYGLLAEQNTAVIEMAAASGLPLLAEAERNPLKTTTYGTGELIAAALDKGIEKIIIGIGGSATNDAGVGMAQALGAKITDKNGRQLAFGGESLAEIDNIDLSSLDPRLKEVEILAACDVDNPLYGENGAAYVYAPQKGADQKMVEILDNNLRKFNQVVMEELNINSNHIAGAGSAGGLGAGLAVFLGAELKAGIEIILNSLDFESRLEGVDFLITGEGRLDGQSINGKVPTGAGRRAQKLQIPVIAVAGSLGEGVEKVLKHGIDAYFCIIDRPADLEAIIKDSPKLLASLSEQLMRTLALSVPGTKR
>NC_014654.1|WP_013405087.1|599236_603829_+|glutamate-synthase-large-subunit
MRFSRMPEKQGLYSPEFEHDACGMGFVSHIKGRKSHQIVEQALEVLVNLSHRGATGSEENTGDGAGILLQIPDQFLRAKALENDFKLPEVGDYGVGLVFLPREEEKRNVIVKIIEDITADEGQKVLGWRDVPVDSSEIGNSAREVMPYFKQLFIKRSAEIKAGIDFERKLYLIRKRLEKKIRNSEYKGELYIASLSSRTLVYKGMLTPGQLKGFYPDLSDPELKSAIALIHSRFSTNTFPSWERAHPNRYLIHNGEINTMLGNQNWMRGRESLFASKAFGNDLAELLPVINEDGSDSARFDNALEFLYLSGRSLAHSMMMMIPEPWEHNDLMEEKKRDFYHFHSTLMEAWDGPAAMAFTDGTQVGAVLDRNGLRPSRYYITDDDLLIVASEVGVLDLPEEKIVSKQRLEPGRMLLLDTEKGRIINDKELKAEISAAEPYGEWLDDNLLKMEEINNMEDSEQDLEIDSKRLLRMQKSFGYSYEDLQKILIPMARDGVDPIGSMGNDASLAVLSDQPQLLYNYFKQLFAQVTNPPIDSIREKLITASKSYLGSEGNLLSPEAKSCRQLELEDPFLSNAQLKKIKELDQAGFKTAEIDIIFDKEENDLEKAINEIFAKADSLIENGTNIIILTDKKINADKLPIPALLAVSALHHHLIKNGSRTKVSIVLESGEPREVHHFALLIGYGLDAVNPYLAYASLVDLVKEGHLEMDSKKAVQKYIKAAVKGVIKVMAKMGISTVQSYRGAQIFEAIGIGEEVIDKYFCRTPSRIGGIGLEEIAKESQLRHDSAFKGIKIERDTLDPGSNFAWRKDGEEHLYNPETIYLLQRAVREDNYQLYKEYAAKINDQSDKMLTLRGLLEPDYAAEAIPLEEVEPAENIMKRFKTGAMSYGSISQEAHEALAIAMNRIGGKSNTGEGGEDPDRYTRDANGDLRNSAIKQVASGRFGVDSSYLVSAEEIQIKMAQGAKPGEGGQLPGKKVYPWVAEVRGTTPGVGLISPPPHHDIYSIEDLAQLIHDLKNANRNADINVKLVSEVGVGTVAAGVAKGKADVILISGYDGGTGASPRTSIRHAGLPWELGLAETHQTLVLNDLRDRVKLETDGKIMTGKDLAVAAMLGAEEYGFATTPLVALGCVMMRVCNKNTCPVGVATQDPELRKKFTGKPEHVVNFMRFMAENLREEMAALGFRTIDEMIGRVDRLGRDKAFDHWKAKGLDYSAILHQPEVARKKAVFCQQKQEHGLENSYDLRELLELSKDAIENGEAIEKDLPIKNTDRVVGTILGSEITKRYGGTGLKEDTIKLNFKGSAGQSFAAYLPKGLTFSLSGDSNDYLGKGLSGGKVIVKKPAEASFKADENIIIGNVAFFGATSGKAYIEGVGGERFAVRNSGVEAVVEGLGDHGCEYMTGGRVVVLGSVGRNFAAGMTGGTAYVLDLNGDFALKANQEMVDLEALPEVEDGPIVKEMIKEHLAYTGSLKAEEILNNWEEYKHKFVRVMPRDYQRMITAIEDFKQQGLCREDALMRAFEENAQDKARVSGN
>NC_014654.1|WP_013405088.1|603850_605317_+|glutamate-synthase-subunit-beta
MGKATGFIEYQREVPEERPVKDRIKDWQEFKTKFSEDAAKIQGARCMECGIPFCHSGLEIGGMVSGCPVNNLIPEWNDLIYKGKWEEAVKRLLKTNNFPEFTGRVCPAPCEGSCTLGLNEPAVTIKQNEYQIIEKAFAEGWMEPQPPETRSGKSVAVVGSGPAGLAAADQLNKLGHWVKVYERQDRIGGLLTYGIPNMKLDKEEVVKRRLDIMEAEGVEFVVSTEVGIDISLTELQKENDAVVLAGGATKARDLKVPGRDAEGVHFAVKFLKENTKKVLDKDNPDYISAEDKDVIVIGGGDTGTDCVATSIRQGCNSVTQFEIMPQPPEARQDSNPWPEWPKTEKIDYGQEEATELYGADPREYLIMTKEIIKDDSGHVKAIRTVKINWDKDEQGNFYPVEKEDTEKIWPADLVLIAMGFLGPEETLINAAGLEQDARSNVKANYGDFRTNLDGVFAAGDMRKGQSLVVNAIDEGRKAAKSVDQYLAE
>NC_014654.1|WP_013405089.1|605497_606232_+|basic-amino-acid-ABC-transporter-substrate-binding-protein
MKKILVLMLLVFAVFAFSFSAYAETYVVGTSAGFPPFEYVEDGEIVGFDMDLITEIGNRQGFEVEFRDISFDSLIPALTTGSIDIIAAAMTITEERAEVLDFSDPYYSANQAVLVHEDSEEGLTILFGDNDIGVQTGTTGDIWVQDHLVEPGILTGNVRNYDSFVLVIRDLANQNIDGVVLDKPVGETYSQGNPVKVVAEIITGEEYGMAVAQGNDELLEKINAGLEEVREDGTMDELIEKYFE
>NC_014654.1|WP_013405090.1|606395_607085_+|amino-acid-ABC-transporter-permease
MLENIVLIQRALPFLLRGTVVTIQLTFWSLLLGVVIGLPLAFAQVYGNKIVTFFTAIYERIARSIPLLVILLLINYALPMLGFRIPVFRAAVLGIGLRSSAYQSQIYRGAIQSVSGSQLKAAMSLGMNKLTAFSHIIAPQAIRIAIPPVTNESAIVLKDTSLAFTIGVVELVRQGDYFIATSNEPMVIYLTVAAIYFILTTTINLALSLFEKKYKIPGIGIEGGHSDAY
>NC_014654.1|WP_013405091.1|607074_607833_+|amino-acid-ABC-transporter-ATP-binding-protein
MPTKHLLKIEDLHHSFGDEEVLKGISLALDKGETKVIVGPSGTGKSTILNNIIRLVPPVSGKIYLEDVEITSTKKINQIRQQIGFVFQDFGLFNHLTAKGNVMIGLTKVKKMDKKEAEKIAIEELDRVGIGNYANSYPSQLSGGQKQRVGIARALAMKPKLILFDEPTSSLDPELTGEVLTVMKNLAQEGMTMLIVTHEMGFARTVADELIFMEGGHIVEQGPPEKLFKNPEHKRTREFLFKLTDLYGEGEE
>NC_014654.1|WP_013405092.1|607832_608495_+|amino-acid-ABC-transporter-permease
MLDIFLDFYPVLFRGLGVTIMITLISCTSGTILGIFLSLGKIYGNKLISRTVTAFIAVIRGTPLLVQLFIIYYGLPAYGIRFAPITAAVISFIINSGAYQAEYLRGSIQSVSSGQLKAALSLGMTKWMGIIYVVLPQALRRVIPAWTNEFIYMIKYSSLAYVIGAKELMTEGKLIASRNYQFFNVYMVVALIYLVVIIIFVYLFNKFEKKVAIPGFDFER
>NC_014654.1|WP_041595759.1|608775_610293_+|FAD-binding-oxidoreductase
MRWEKVSIAQKGKKKVVVQNLIDLLSEKQVNTNEEDLYEASVDRYKKFAFARNAIDVPKPVAIVYPNSSEEVSSILEFCNQQKINVIPRSGDTSTEGGLENWKENTIIIDAENLDKIVDINTYNMEAKVQAGVPLEELENALREKGFTTGHSPQSKPVAKMGGLVATRSIGQLSTLYGGIEDMVIGLECVFPDGHIANIKNVPRRAGGPDIRHIAIGNEGTLCYITEVTVKIFKYYPDNNKFFGYLTEDIETGIKVLREVMVNGYRPSVARAYSEEDANQHFYHFSKDKCVLILMAEGPENIVEATGEAIEEAVKKFSDGIIEEVDSELIENWFNNLNWSQQDIDDEYEGMIENDSHTGFTTEISANWETIPVIYNNVMKRIKEEFPRAHELTLLGGHSSHSYINGTNLYFVYNYEINCAPEDELRVYHHPIHKIIVDETLKQGGSMCHHHGIGKYRSEWTKEEHGSAYYMLEKLKEAFDPNDIMNYGSIFPKEDGIKKYINKEK
>NC_014654.1|WP_160143091.1|610540_611827_+|MFS-transporter
MKKKDLKRYIQFSLVVLAAGAIYPVVYMRTQFQETILEVFNMTSGQFNNIYSILGIVFIVGYLPSGLLSDKFSAKNLLTVSLLGTAAGGFWFAQVPDYPQVQIIFAIWGFFTVFTFWSAHMKLVKMMSTDDDEGRFFGILDGGRGIIEAGLGSVAAFIFAQVLGSSTELAIKTDALTSVIYMYSFVLLITAVLIFIFVEKQQKDLESKADKSKASSFKLSDLKKVFKNKYIYLQGGIVFMGYSVFWTSYYVGGFLETNVGVTSVAVGTIMGIVLWMRPLGGFLGGYLADKVGKEKTVGGAILGASITLVLIATLPTAINNYIFYTLAIILAIFYYAIRGTYWALLGKANISPLILGTGIGIISLIGYFPDILIPQLNSFLFNTFGDTGGYNAYFLVSAFIGLCGVLIAGIYYKINQKEIKENAEKEVA

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Crispr_ID: NC_014654_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014654_3

1520849-1520931

Orphan

Consensus_repeat	Method
CCTTCGCGCTATATCTTCATTTTA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014654_3

>merge|NC_014654|3|1520849-1520931|CRISPRCasFinder
CCTTCGCGCTATATCTTCATTTTATTACGCATGGTCGACTCAGCACTTGGTCATCGAGACCGTCGCGCTATATCTTCATTTTA

>NC_014654|3|3|1520849-1520931|CRISPRCasFinder
CCTTCGCGCTATATCTTCATTTTA	TTACGCATGGTCGACTCAGCACTTGGTCATCGAGA
CCGTCGCGCTATATCTTCATTTTA

Protein	Signature genes	Signature genes Name	Protein_function
NC_014654.1\|WP_041596000.1\|1517213_1517777_-\|ATP-dependent-protease-subunit-HslV	unknown	unknown	gnl\|CDD\|235477
NC_014654.1\|WP_013405849.1\|1511610_1512168_-\|ribosome-recycling-factor	unknown	unknown	gnl\|CDD\|178850
NC_014654.1\|WP_013405867.1\|1530306_1531845_+\|YifB-family-Mg-chelatase-like-AAA-ATPase	unknown	unknown	gnl\|CDD\|223679
NC_014654.1\|WP_013405863.1\|1525837_1526455_-\|MotA/TolQ/ExbB-proton-channel-family-protein	unknown	unknown	gnl\|CDD\|376576
NC_014654.1\|WP_013405857.1\|1520104_1520584_-\|DUF494-family-protein	unknown	unknown	gnl\|CDD\|377328
NC_014654.1\|WP_013405848.1\|1511397_1511607_-\|hypothetical-protein	unknown	unknown	unknown
NC_014654.1\|WP_013405860.1\|1523796_1524468_+\|NAD-binding-protein	unknown	unknown	gnl\|CDD\|236541
NC_014654.1\|WP_013405852.1\|1514028_1514787_-\|30S-ribosomal-protein-S2	unknown	unknown	gnl\|CDD\|235396
NC_014654.1\|WP_013405851.1\|1513022_1513922_-\|elongation-factor-Ts	unknown	unknown	gnl\|CDD\|236491
NC_014654.1\|WP_013405858.1\|1521004_1522150_-\|DNA-protecting-protein-DprA	unknown	unknown	gnl\|CDD\|376794
NC_014654.1\|WP_013405859.1\|1522282_1523773_+\|TrkH-family-potassium-uptake-protein	unknown	unknown	gnl\|CDD\|223246
NC_014654.1\|WP_013405865.1\|1527583_1529368_-\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|238657
NC_014654.1\|WP_013405861.1\|1524530_1525289_-\|SIMPL-domain-containing-protein	unknown	unknown	gnl\|CDD\|377344
NC_014654.1\|WP_013405862.1\|1525437_1525836_-\|biopolymer-transporter-ExbD	unknown	unknown	gnl\|CDD\|376792
NC_014654.1\|WP_187323459.1\|1515847_1517221_-\|ATP-dependent-protease-ATPase-subunit-HslU	unknown	unknown	gnl\|CDD\|235364
NC_014654.1\|WP_013405850.1\|1512186_1512906_-\|UMP-kinase	unknown	unknown	gnl\|CDD\|234735
NC_014654.1\|WP_013405856.1\|1517999_1520075_-\|type-I-DNA-topoisomerase	unknown	unknown	gnl\|CDD\|235516
NC_014654.1\|WP_013405866.1\|1529922_1530288_+\|YraN-family-protein	unknown	unknown	gnl\|CDD\|237119
NC_014654.1\|WP_013405853.1\|1515033_1515816_-\|GTP-sensing-pleiotropic-transcriptional-regulator-CodY	unknown	unknown	gnl\|CDD\|235230
NC_014654.1\|WP_013405864.1\|1526469_1527558_-\|energy-transducer-TonB	unknown	unknown	gnl\|CDD\|367555

Protein	Function_ID	Function_description	E-value
NC_014654.1\|WP_041596000.1\|1517213_1517777_-\|ATP-dependent-protease-subunit-HslV	gnl\|CDD\|235477	PRK05456, PRK05456, ATP-dependent protease subunit HslV.	1.53224e-117
NC_014654.1\|WP_013405849.1\|1511610_1512168_-\|ribosome-recycling-factor	gnl\|CDD\|178850	PRK00083, frr, ribosome recycling factor; Reviewed.	2.60513e-95
NC_014654.1\|WP_013405867.1\|1530306_1531845_+\|YifB-family-Mg-chelatase-like-AAA-ATPase	gnl\|CDD\|223679	COG0606, COG0606, Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones].	0
NC_014654.1\|WP_013405863.1\|1525837_1526455_-\|MotA/TolQ/ExbB-proton-channel-family-protein	gnl\|CDD\|376576	pfam01618, MotA_ExbB, MotA/TolQ/ExbB proton channel family. This family groups together integral membrane proteins that appear to be involved translocation of proteins across a membrane. These proteins are probably proton channels. MotA is an essential component of the flageller motor that uses a proton gradient to generate rotational motion in the flageller. ExbB is part of the TonB-dependent transduction complex. The TonB complex uses the proton gradient across the inner bacterial membrane to transport large molecules across the outer bacterial membrane.	9.05434e-30
NC_014654.1\|WP_013405857.1\|1520104_1520584_-\|DUF494-family-protein	gnl\|CDD\|377328	pfam04361, DUF494, Protein of unknown function (DUF494). Members of this family of uncharacterized proteins are often named Smg.	3.47972e-07
NC_014654.1\|WP_013405860.1\|1523796_1524468_+\|NAD-binding-protein	gnl\|CDD\|236541	PRK09496, trkA, Trk system potassium transporter TrkA.	1.49692e-38
NC_014654.1\|WP_013405852.1\|1514028_1514787_-\|30S-ribosomal-protein-S2	gnl\|CDD\|235396	PRK05299, rpsB, 30S ribosomal protein S2; Provisional.	4.86088e-172
NC_014654.1\|WP_013405851.1\|1513022_1513922_-\|elongation-factor-Ts	gnl\|CDD\|236491	PRK09377, tsf, elongation factor Ts; Provisional.	8.71505e-141
NC_014654.1\|WP_013405858.1\|1521004_1522150_-\|DNA-protecting-protein-DprA	gnl\|CDD\|376794	pfam02481, DNA_processg_A, DNA recombination-mediator protein A. The SMF family, of DNA processing chain A, dprA, are a group of bacterial proteins. In H. pylori, dprA is required for natural chromosomal and plasmid transformation. It has now been shown that DprA is found to bind cooperatively to single-stranded DNA (ssDNA) and to interact with RecA. In the process, DprA-RecA-ssDNA filaments are produced and these filaments catalyze the homology-dependent formation of joint molecules. While the E.coli SSB protein limits access of RecA to ssDNA, DprA alleviates this barrier. It is proposed that DprA is a new member of the recombination-mediator protein family, dedicated to natural bacterial transformation.	4.17535e-95
NC_014654.1\|WP_013405859.1\|1522282_1523773_+\|TrkH-family-potassium-uptake-protein	gnl\|CDD\|223246	COG0168, TrkG, Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism].	1.60044e-84
NC_014654.1\|WP_013405865.1\|1527583_1529368_-\|TonB-dependent-receptor	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	5.75581e-85
NC_014654.1\|WP_013405861.1\|1524530_1525289_-\|SIMPL-domain-containing-protein	gnl\|CDD\|377344	pfam04402, SIMPL, Protein of unknown function (DUF541). Members of this family have so far been found in bacteria and mouse SwissProt or TrEMBL entries. However possible family members have also been identified in translated rat (Genbank:AW144450) and human (Genbank:AI478629) ESTs. A mouse family member has been named SIMPL (signalling molecule that associates with mouse pelle-like kinase). SIMPL appears to facilitate and/or regulate complex formation between IRAK/mPLK (IL-1 receptor-associated kinase) and IKK (inhibitor of kappa-B kinase) containing complexes, and thus regulate NF-kappa-B activity. Separate experiments demonstrate that a mouse family member (named LaXp180) binds the Listeria monocytogenes surface protein ActA, which is a virulence factor that induces actin polymerization. It may also bind stathmin, a protein involved in signal transduction and in the regulation of microtubule dynamics. In bacteria its function is unknown, but it is thought to be located in the periplasm or outer membrane.	3.91134e-19
NC_014654.1\|WP_013405862.1\|1525437_1525836_-\|biopolymer-transporter-ExbD	gnl\|CDD\|376792	pfam02472, ExbD, Biopolymer transport protein ExbD/TolR. This group of proteins are membrane bound transport proteins essential for ferric ion uptake in bacteria. The Pfam family consists of ExbD, and TolR which are involved in TonB-dependent transport of various receptor bound substrates including colicins.	4.42433e-24
NC_014654.1\|WP_187323459.1\|1515847_1517221_-\|ATP-dependent-protease-ATPase-subunit-HslU	gnl\|CDD\|235364	PRK05201, hslU, ATP-dependent protease ATPase subunit HslU.	0
NC_014654.1\|WP_013405850.1\|1512186_1512906_-\|UMP-kinase	gnl\|CDD\|234735	PRK00358, pyrH, uridylate kinase; Provisional.	9.66586e-139
NC_014654.1\|WP_013405856.1\|1517999_1520075_-\|type-I-DNA-topoisomerase	gnl\|CDD\|235516	PRK05582, PRK05582, type I DNA topoisomerase.	0
NC_014654.1\|WP_013405866.1\|1529922_1530288_+\|YraN-family-protein	gnl\|CDD\|237119	PRK12497, PRK12497, YraN family protein.	1.4719e-36
NC_014654.1\|WP_013405853.1\|1515033_1515816_-\|GTP-sensing-pleiotropic-transcriptional-regulator-CodY	gnl\|CDD\|235230	PRK04158, PRK04158, GTP-sensing pleiotropic transcriptional regulator CodY.	3.77028e-168
NC_014654.1\|WP_013405864.1\|1526469_1527558_-\|energy-transducer-TonB	gnl\|CDD\|367555	pfam03544, TonB_C, Gram-negative bacterial TonB protein C-terminal. The TonB_C domain is the well-characterized C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance.	8.40433e-23

>NC_014654.1|WP_013405857.1|1520104_1520584_-|DUF494-family-protein
MNKNVIEILTLLMQIFIDKIDLLSLKKDITDSLEEQGYELEDINKAFEFMYKDPFAVSENDFYSDQKDSGYNRVFTKIEKLYFDDEVKNIIIKLNKSGLLNTEKLEVIIDQLLSMAFFNNLTIESMWDVIDEIVEDDYKLYIISESINEFNGKAIKFQM
>NC_014654.1|WP_013405856.1|1517999_1520075_-|type-I-DNA-topoisomerase
MAKKNKNLVIVESPAKAKTIAKFLGRNYKVKASMGHVIDLPKSKMGIDIENNFEPNYITIRGKGKTLAKLRKEAKKSNEVYLATDPDREGEAISWHLSHALKLSEEDNNRIEFNEITKNAIKNAIKKPRQIDKNLVDAQQARRLLDRLVGYRLSPLLWKKVRKGLSAGRVQTIAVKLICEREEEIRNFEEEEYWTIDVDLKKDKDKLTASLYRIDNKKYNIDSEEAANKIVSDIKKEDFEIIKVKKRKRRRNPKSAFTTSTLQQTASSKLNYSAKKTMYLAQQLYEGMDIGSSGSVGLISYIRTDSTRLSEEAKAGAAKYIEAEFGDKFLRSKKKKKKKNKNSQDAHEAIRPTDTMRTPDKMKKHLSKDQYKLYDLIWRRFVASQMSPALYESISAQFKAGEKYKFRVSGSRLLFPGHLILTGKAKEDKIDLPVLKEGDVYKLQDVKPEQHFTKPPARFSEASLVKTLEEEGIGRPSTYAPTLSTIVSRDYVEKDGRYLKPTELGETVTELLSEYFPDVTDVEFTASLEQRLDEIEKGNEDWKKLLKDFYQPFYERLEHARENMERVQIVEETDEVCEVCGKPMVVKYGRYGKFLACSGYPDCKNTKPYLIKTGVDCPECDDGEVIERTSKKGRTFFGCSNYPECNFMAWNKPVEKPCPECGGVMVEKTTKAKGEHYKCINKECGHTEKAE
>NC_014654.1|WP_041596000.1|1517213_1517777_-|ATP-dependent-protease-subunit-HslV
MTEFEATTIVAVRHNNCMALAGDGQVTLGNTVMKSTAKKVRRLYNGEILAGFAGTSADAFTLFEKFEAKLEEYHGSLQRAAVELAKEWRTDKILRKLEALLIVANLEEILIISGNGDVIEPDANISAIGSGGPYARAAASALSNHGNDLSAGDIAREALQIAASICIYTNENITLEELDGGESKNSE
>NC_014654.1|WP_187323459.1|1515847_1517221_-|ATP-dependent-protease-ATPase-subunit-HslU
MNNELTPKEIVSELDKYIIGQDDAKKSVAIALRNRYRRKLVRDDMKDEIIPKNILMIGPTGVGKTEIARRLAKIARAPFIKIEVTKFTEVGYVGRDVESMIRDITETSIRMVKEHKMEKVEVEAEKMAIERIVDIMLPGKNKKKDDYFSKMADKDESKDELDDRVKARRQRMFERIKEGKLDDHKIEIEVEANSQQMLEVFSGSGVEEMGINFQDMLGNIFPSKKKKKKVTIKQAKEILKQSEAQKLIDMEQVKSEAIDKVENDGIIFLDEIDKIAGRESGSGPEVSRQGVQRDILPIVEGSTVVTKHGSVKTDHILFIAAGAFHVSSPADLIPELQGRFPLRVNLNSLSRENFKDILLLPQNSLIKQYKALLETEGVEIEFSEEAVEEISNFAFDINEETENIGARRLHTIMEKLLEDLSFEAPGLETDKIIIDVDYVHDKLKDVVADKDLSKYIL
>NC_014654.1|WP_013405853.1|1515033_1515816_-|GTP-sensing-pleiotropic-transcriptional-regulator-CodY
MGSLLEKSRKINRLLQRTGGNAVDFSDMAYVLKEAIKCNAYVTSKKGKILGYSLLDDFECDIMEDKVISKGEFPEEYNQGLLRIRETKSNIEQKEGKCVFAEGEDCLFEDKLTTIVPVIGGGDRLGTLVLARYGSKFDDEDLVLGEYGASVVGMEILRARSDRVEKEARKKAAVQIAIDTLSYSELEAIEHIFEELDGEEGLLVASKVADRVGITRSVIVNALRKFESAGVIESRSLGMKGTYIKVLNDNLLPELEKLKA
>NC_014654.1|WP_013405852.1|1514028_1514787_-|30S-ribosomal-protein-S2
MSVVNMKQLLESGVHFGHQTKRWNPKMEPYIFTERNGIYIIDLQQTVKLIDKAYNFVKEEAAEGKKVLFVGTKRQAQETVKKEAERCGMPYVNQRWLGGMLTNYHTIKKRIDRLDELEEMEEEGIFEVLPKKEVIELNKEHDKLERFLGGIRNMNGLPDVIFITDAKKEDIAVKEAIKLDIPIVSILDTNCDPDLIDYVIPGNDDAIRAVKLITSVISDAVLAGKQGRQEQKAQEQQEAEAEAVQAEADTEQ
>NC_014654.1|WP_013405851.1|1513022_1513922_-|elongation-factor-Ts
MGVTMKDIKELRSRTGAGVLDCKKALNAVDGDVEAAVEHLREKGISDAAKKAGRIAAEGLVSLNISDDRKKGILVEVNSETDFVAKNDKFQNLVADITEHVMQSDADNTDQIAEEKWYKNSDKTVNDIIKEAIASIGENINLRRFVSYESDGFIYGYIHLGGKIGVLVDFEDEFSAEKEAVAKDIAMHIAAINPDFLDRDSVSENYIEKEKKIYKEQMINEGKPEHIIDQIVEGKLNKYYTQVCLLEQPFVRDDEKTVADILEENDLTVKRFTRFEIGEGIEKKEDDFVAEVKAATKNQ
>NC_014654.1|WP_013405850.1|1512186_1512906_-|UMP-kinase
MTEKPVYSRVILKISGEALSGTNGYGIDPEMIQKIAAEISEVVKSTNVEMAIVVGGGNIFRGIAGSAKGMDRGTADYMGMLATVINALALQDAIEKFEIETRVQSAIEMRQIAEPYIRRRAIRHLEKGRVVIFAAGTGNPFFSTDTTAALRAAEIGADVILMAKNVDGIYDSDPEINSNAKKHDSLSYIDLLNNSLRVMDFTAVSLCMDNEIPLKVFAVKKEGNIKRVLLGDKIGTSVN
>NC_014654.1|WP_013405849.1|1511610_1512168_-|ribosome-recycling-factor
MFNEVLKETEERMKKALEATKEDLNTIRTGRARPSLVENIKANNYGVATPIQQMAKVMAPEARQIVIEPWDKNNIEAIEKAIMQENLGLNPSNDGNVIRINIPQLTEERRKELTKILHKKAEDGKIAIRNIRRDANEELEMLEDEGEISEDNMHRGFDNVQDLTDTYIGKIESITEKKENEIMEV
>NC_014654.1|WP_013405848.1|1511397_1511607_-|hypothetical-protein
MSLQKEKLLASQLGDALEILAKNEIKYKLKETKPPLKNIKKSNSKHKRVIRIKEKADFLEIIWSFQYNR
>NC_014654.1|WP_013405858.1|1521004_1522150_-|DNA-protecting-protein-DprA
MDNIEEYYLIYLNSIRGFGPKTIHELYQKLKRISKLWKLKKKELKALNLNSKKINSFLNCKGDFNYYQLKKSLKEKNINFLTLYNSRYPKKLMNIYDPPPVIFYQGQLNFNLPAVAVIGSRKSTLYGRKIASKTSAALAAKGINIISGMANGIDSTAHKGALSVESGITTAVFANGFNYIYPSENNYLAKKIKKEGLLITEFNPEIPPKAGNFPRRNRIISALADLILVVEAGKKSGTLITVDYALEQGKDIMAVPANIDRPTGVGCNKLLKKGAAVFTEVQDILDYLNNYLQKERPNADFIQDRNELQKVYPELNYDEKKILYLFQYELEIYYDDLIRLSNLTTDKVDKILIKFELMDLIQRLKGKKYRFKGLQNLLKPI
>NC_014654.1|WP_013405859.1|1522282_1523773_+|TrkH-family-potassium-uptake-protein
MIKSTKYNTIFYYLSSLSFILAIMIVIPLVVSFYYQDGRQIYQAFYYSIIISFAAGILLKLPTDKEKTYIDLTTAMLLCALGWILVSILGSLPFMIGIEKSFIDALFETVSGFTTTGITVFTGLELMPRSILFWRSLIQLLGGLGILTFFLLVSTRAKGETWQLFSAESHKINVSRPVPNVFKTVKILWSIYLGFMLLQTLLLIILGLSPFDALTHSFTTLSTGGFSSYDASVAHFAANNYSNYILIEYVITFFMFLGGVNFLLHYRLFQKDFESIKNNSEFRTMVKIIIYSTIFLSLVIITLETAPGISVEEVFRRTIFQVTSILTTTGYATKDINSAFFPAAARQLFLAFMLIGGCVGSTSGGIKIMRLNILRALFKREVKKIYLPNHAVLPVTVDRKIIRKDELNKLTGIFTFWLVLIVVGGIITSLFSHLDGWQAYSGMFSAMGNIGPFFFSVEEMSNISPVVKTTYIIGMLAGRLEILPVIILFSKKAWQN
>NC_014654.1|WP_013405860.1|1523796_1524468_+|NAD-binding-protein
MYIIIAGGGIAGSNLTKNLVNDHDVIVIEKDQQVAERVYSRYGAVTVLGNATRIDILKEAGIEKCDVAIAVMRNDADNLSFSLLAKNFGVKKILVRMREPQYKSAYKMAGATNIAATMELIVDRFITDIEEPDVRKVASLGDGKAEVSILTIPKESKISGKKISEIVSQENFPENCIIAGIFDKEMDRYIVPRGNREIFAGNQVFLVASKTDMEKAANFLLEK
>NC_014654.1|WP_013405861.1|1524530_1525289_-|SIMPL-domain-containing-protein
MNRNAGLFLVFLALILLSVLVINGLYFNTNDEVVAPEEVVEERVEEDYITTSLSISQQKEFDPEIVDVVLGFENEDQEQSVAVRENNEIVSALMDILEEEDLESLETQYFRVYPFTRYEDEERVTYYRVSNQLKFRTEHLEELPVLLGRLLEAGANRVVSLDYRLRNNEAALDEVTAMALDSLKSKSAFIAQNLDKEDYRITKLNMGRQDIYGADMLQSVGRRSAEADSMEVPVKEEKVNISVSLSAEVELY
>NC_014654.1|WP_013405862.1|1525437_1525836_-|biopolymer-transporter-ExbD
MKYKPKNRDGSLGLAPMIDIVFLLLIFFLVSSTLQGEEAIYNITVPDSSIGQTADGEQINIFLSEDNKIYYQEVEYNPGQLELLFRDIGEREDKSVKIYADRKTDFENLVALIEELKQNNFEQISFSLRERR
>NC_014654.1|WP_013405863.1|1525837_1526455_-|MotA/TolQ/ExbB-proton-channel-family-protein
MIGEFINKAGIIAYPLLLSAFLVIFMVFERSIIYFLKYRSIKKTKYLRDIKEFYNDQADEDNLIVKNKGITAQIYNAVLSKKPVNKEQFQLFMDAEEVDKLPELERGLGLLNFLAQASPTLGLLGTVSGMINTFQVLGIGGSPEQMAVGISEALFTTAAGLVISLPALAFYHYFYSKIDKLVNQMDNLRLETKNLLYNGYKKEID
>NC_014654.1|WP_013405864.1|1526469_1527558_-|energy-transducer-TonB
MKKEDKFVFVLSFILSLSMLFLLEACPFRLLANDIQVVEREEVEIELLLSDAAELFEEEGGSEAAEDSDSALEEEIAQEDSTSEAEVSEEVEPEPDRETETQYEETEEELAEEPEEVEERPEIEEEPEEEIEEVEEKPEVEEVVEIEEEIEEEPEELEEVEVVEEAEVEVEEELNESEEEQLPEWVLNQNEVEEPEESEDDSFDLDSYLAELRNNNDDADDEENEVVDEIVNRESEEVESSQPAEEQIENGGSDDTDSGEDEIYDLRENGHSGIDRPSIRNHRAPEYPPQMRRRNIEGRVILSLKIDQDGKTSEFEIHDSSGYDAFDQAALSAVKEWEFEAAKLDDQFVSVRITLPIRFELD
>NC_014654.1|WP_013405865.1|1527583_1529368_-|TonB-dependent-receptor
MLKRAVLVLLAALLIFVIPVGAQEDVIDLDEVVVTASRYEEAIMDTPVSIEVISQEDIAQSNSQNVADLLNTYTGVSITDFGGPAGAKQVNIRGASASQVLILLDGQPINEPQNGGFDLGLIPTNNIERIEVIKGPASVIYGANAMGGVVNIITKDIEVEPQTRVSLNYGSYNNFTYELSHSQRFDDLGVYLSYLNRDSDGLEDGEKLEQETVFARLNYQLSNHSDLTFTFEDNTSDKIIGGSVQDDHFQNLNLKWNTQKENRDTSVSVFRNYQERLYPSDGSKHERYQTGLNINNTNYFDNHILNYGFEIKEDDVESTDIIGGQQKNTNKALYIQDDWGINDQLNLKIGARYDDHEEYGSELSPQIGANYKLSDNYSLVASAAQAFRAPTFDDLYGTYPPNPDWFFPGFEGNPDLKAETSDNYEIGLRFNFQNTSGQLSLFQRKVDNLITSFEDNGINTRINIEGTSEFKGIELGLDRKLAENINTKLNYTYLDARDQNDNRLANQPYHNAKLSLNYNDQVNRISLDGRLVAGRLDMPSYFVLDSRFSRPLEIRERDFNMTFSINNLLDRDYQVVSPLDMPGRNFMLSLGTSF
>NC_014654.1|WP_013405866.1|1529922_1530288_+|YraN-family-protein
MALHNQIGELGEDIAAKHLKNKGYLIIERNYRNNFGEIDIIAQKDDYTIFIEVKSRTSEDYLYLAENLYYTQIEHLKNTASYYFLENDKEIDNIRFDLIAIKINKIDKTADELKHFKNIID
>NC_014654.1|WP_013405867.1|1530306_1531845_+|YifB-family-Mg-chelatase-like-AAA-ATPase
MYSFVHSAVISGVKAEIVRVEIDISRGLPGFHIVGLAGKTVKESAKRVRSAIINSGFEWPIKKITVNLAPGNIQKYGSHFDLAIAAVLLECSGQIKIKNREKKIFAGELNLNGDLNKVKGVLAMLIEAEKNNIKEAVLAAENQKETELIENIDSYFLYNLSQLTDLIKVKNNNFFTRDIEEKNRVNRKDNYFELNFIRGQHNAKRALITAAAGGHNLLFVGPPGCGKTILAASIVKLLRPLSSQELLETASIYSVSDNLEKLNFKKRYRPFVAPHHSITSAALIGGGRIPVPGEISLAHNGVLFLDELPEFKAAVLANLREPLERKKIKIARNNGSYIFPANFQLIAAMNPCPCGYAGVKNKSCSCSERDIIKYQQKLSGPLLDRIDLQIEVPPLESEEILLKSSQTKLINYQEKIKNARIMQAQRYKNSRLKNNSELELKDIEKYCSLKRSAQKILKDAVKKINLSMRGYIRLMRVSRTIADLKSHHNIKKEDLIEAIDFRWLAENSKMLY

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Crispr_ID: NC_014654_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014654_4

1666592-1670122

TypeI-B

I-B

Consensus_repeat	Method
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	PILER-CR
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CRISPRCasFinder
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CRT

48 spacers

cas6,cas4,cas2,cas1,cas3,cas5,cas7,cas8b1,WYL

The CRISPR arrays of NC_014654_4

>merge|NC_014654|4|1666592-1670122|PILER-CR,CRISPRCasFinder,CRT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCTTTCAATCTGTAAAGTATAATGTAACTAGGACTTAAGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCCCTGGCCCGGCTCTACTATTTGCTCTAGTTTACGAAAGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCCTAAAGATTTTAGCAGCTATGCAAATACAGATTACAGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCCCAAAATATCTTTTTGCGTTCTCGGCGTTTTTTTCGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCCCTTGAGAGTTTTCGAATTGACTTATCTGGTCTTTAAGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCTCATCATCTTGATCCTGATCGTCCATCTCATCCAGATGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCGAATAACGATGAAGAGCAGACTGATCTCGATCCGATGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCAAGTTCTCCATTTACATCTGGGAAATATCCATTTTGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCTTTTTGTAGGATTTTATAATGCAATTGGGAAATTTCGGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCCTATAACTTCTCGCTGGATAGTTCTACCTAATTCCTGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCTGTTTTATAACACTTGTCAAAATATTTAAGTTATTTGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCATGATGGACAATTAAAAAAAACTTTTGAATCCTTGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCCCATTCGTAGTTGTTTTCTATGATAGGAGTATCACACGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCTTATCCATAGACACATAGCCCTCATATGCACCAAGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCAGGGTTTATATCGTGGCGAGAGCTACTCAGATATGTCGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCTAATATACAGACACCTTTTGCTATGTTAACAAAATAGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCAAGCTAGATGTAGGCAGGGTTTTATACTTTAATGCATGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCAATTAAGCAGTAAAGCATGGAATTCACTTTATATGTGGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCATTGCCATCTGTTATTCCTCCTATATATTCAATATTTGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCTTAGTTGAAAATTCTTATGCAGCTTCACCTATATGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCAAGATGTTTTAATTGAGAAAGGACAAATGCTAGAAAGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCCTACTTGACCTTTTTTCATAACTTAACCACCTCCTGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCTAACAAACATAAGAGGGATAAGGATAATTATGCTCCGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCAAGATAGCTGAAAGCCGAAAGCGTCTACGAGAACAGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCTCGCAACAAAGTCAGCCCAAACCACCAACAACCAAGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCTACTAACCACTCATCGCCGCCATTAACCTGATTGAGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCTCATCAAGTGGTTTGGCTTGTTGTGTAGCAGCGAAGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCTTTCTTTCATCTGGCATCATTTAATCTCCCTTCATGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCAAGCCATGTGCTTATCCAGGATGCCCTAAATTAATGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCCTAAGATTGGATATTGATGACGAAGAAATGCTAATGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCTACCTCCCAGTCTTCTGGAAGGCTCATTATATAAGCGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCCAATGCAACAACTTCTCATCCATCTTATGTTGTGCGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCATATTCCAAGAAATTAAGAGGATAACAGGAAAGGGGGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCTACTTTACCTACTTTGTTGTACTTTTTAAGCTCCTGGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCAGTGAGCCTCTCCGTCTTCCCCGACCTTGATAGCTTGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCAATGGTAGCTGCTTTTATTGATGATAACAAGCCTGAGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCCCTATCAGGTTCGCCTTGTTGATACCCTGGTTGCCAGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCTCAGTTTCCCAAACTAACCTCGTTACTCCTCCAGCCAGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCAATTAATTATGAAAAAGAATGGTGTTATTTATTTAAGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCTGATTCAGCATCGCCACGAAGCAATCCTTCAACAAGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCTAAGGTGGTGAAGGATTGATGAGATTTAAGTCTTTAAGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCTTTAATAATTCATTTTCAATTTTTCTTTTTAACTTGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCAGAGTGCTAATAACGGAGGAACTGTTGAGCTTACATGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCCAAGCTCGTCCCTATTATCATCAAAACCACCTCTGAGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCTAATAGGGAGTCTTGTGTAGTCAAATACTTTTGAAAGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCAGCGAGCCGGCTAACTCATCTATTACTACAGGCAAGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCCAGATATGATGGCCTGGGCTATACTACACAGGATATGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGCCACGATTATAACTGCAGAGATCGCAATGGCAATCTGTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC

>NC_014654|4|1|1666592-1670122|PILER-CR
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TTTCAATCTGTAAAGTATAATGTAACTAGGACTTAA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CCTGGCCCGGCTCTACTATTTGCTCTAGTTTACGAAA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CTAAAGATTTTAGCAGCTATGCAAATACAGATTACA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CCAAAATATCTTTTTGCGTTCTCGGCGTTTTTTTC
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CCTTGAGAGTTTTCGAATTGACTTATCTGGTCTTTAA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TCATCATCTTGATCCTGATCGTCCATCTCATCCAGAT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	GAATAACGATGAAGAGCAGACTGATCTCGATCCGAT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	AAGTTCTCCATTTACATCTGGGAAATATCCATTTT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TTTTTGTAGGATTTTATAATGCAATTGGGAAATTTCG
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CTATAACTTCTCGCTGGATAGTTCTACCTAATTCCT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TGTTTTATAACACTTGTCAAAATATTTAAGTTATTT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	ATGATGGACAATTAAAAAAAACTTTTGAATCCTT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CCATTCGTAGTTGTTTTCTATGATAGGAGTATCACAC
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TTATCCATAGACACATAGCCCTCATATGCACCAA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	AGGGTTTATATCGTGGCGAGAGCTACTCAGATATGTC
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TAATATACAGACACCTTTTGCTATGTTAACAAAATA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	AAGCTAGATGTAGGCAGGGTTTTATACTTTAATGCAT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	AATTAAGCAGTAAAGCATGGAATTCACTTTATATGTG
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	ATTGCCATCTGTTATTCCTCCTATATATTCAATATTT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TTAGTTGAAAATTCTTATGCAGCTTCACCTATAT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	AAGATGTTTTAATTGAGAAAGGACAAATGCTAGAAA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CTACTTGACCTTTTTTCATAACTTAACCACCTCCT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TAACAAACATAAGAGGGATAAGGATAATTATGCTCC
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	AAGATAGCTGAAAGCCGAAAGCGTCTACGAGAACA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TCGCAACAAAGTCAGCCCAAACCACCAACAACCAA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TACTAACCACTCATCGCCGCCATTAACCTGATTGA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TCATCAAGTGGTTTGGCTTGTTGTGTAGCAGCGAA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TTTCTTTCATCTGGCATCATTTAATCTCCCTTCAT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	AAGCCATGTGCTTATCCAGGATGCCCTAAATTAAT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CTAAGATTGGATATTGATGACGAAGAAATGCTAAT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TACCTCCCAGTCTTCTGGAAGGCTCATTATATAAGC
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CAATGCAACAACTTCTCATCCATCTTATGTTGTGC
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	ATATTCCAAGAAATTAAGAGGATAACAGGAAAGGGG
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TACTTTACCTACTTTGTTGTACTTTTTAAGCTCCTG
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	AGTGAGCCTCTCCGTCTTCCCCGACCTTGATAGCTT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	AATGGTAGCTGCTTTTATTGATGATAACAAGCCTGA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CCTATCAGGTTCGCCTTGTTGATACCCTGGTTGCCA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TCAGTTTCCCAAACTAACCTCGTTACTCCTCCAGCCA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	AATTAATTATGAAAAAGAATGGTGTTATTTATTTAA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TGATTCAGCATCGCCACGAAGCAATCCTTCAACAA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TAAGGTGGTGAAGGATTGATGAGATTTAAGTCTTTAA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TTTAATAATTCATTTTCAATTTTTCTTTTTAACTT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	AGAGTGCTAATAACGGAGGAACTGTTGAGCTTACAT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CAAGCTCGTCCCTATTATCATCAAAACCACCTCTGA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TAATAGGGAGTCTTGTGTAGTCAAATACTTTTGAAA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	AGCGAGCCGGCTAACTCATCTATTACTACAGGCAA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CAGATATGATGGCCTGGGCTATACTACACAGGATAT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CACGATTATAACTGCAGAGATCGCAATGGCAATCT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC

>NC_014654|4|4|1666592-1670122|CRISPRCasFinder
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TTTCAATCTGTAAAGTATAATGTAACTAGGACTTAA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CCTGGCCCGGCTCTACTATTTGCTCTAGTTTACGAAA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CTAAAGATTTTAGCAGCTATGCAAATACAGATTACA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CCAAAATATCTTTTTGCGTTCTCGGCGTTTTTTTC
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CCTTGAGAGTTTTCGAATTGACTTATCTGGTCTTTAA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TCATCATCTTGATCCTGATCGTCCATCTCATCCAGAT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	GAATAACGATGAAGAGCAGACTGATCTCGATCCGAT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	AAGTTCTCCATTTACATCTGGGAAATATCCATTTT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TTTTTGTAGGATTTTATAATGCAATTGGGAAATTTCG
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CTATAACTTCTCGCTGGATAGTTCTACCTAATTCCT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TGTTTTATAACACTTGTCAAAATATTTAAGTTATTT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	ATGATGGACAATTAAAAAAAACTTTTGAATCCTT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CCATTCGTAGTTGTTTTCTATGATAGGAGTATCACAC
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TTATCCATAGACACATAGCCCTCATATGCACCAA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	AGGGTTTATATCGTGGCGAGAGCTACTCAGATATGTC
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TAATATACAGACACCTTTTGCTATGTTAACAAAATA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	AAGCTAGATGTAGGCAGGGTTTTATACTTTAATGCAT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	AATTAAGCAGTAAAGCATGGAATTCACTTTATATGTG
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	ATTGCCATCTGTTATTCCTCCTATATATTCAATATTT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TTAGTTGAAAATTCTTATGCAGCTTCACCTATAT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	AAGATGTTTTAATTGAGAAAGGACAAATGCTAGAAA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CTACTTGACCTTTTTTCATAACTTAACCACCTCCT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TAACAAACATAAGAGGGATAAGGATAATTATGCTCC
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	AAGATAGCTGAAAGCCGAAAGCGTCTACGAGAACA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TCGCAACAAAGTCAGCCCAAACCACCAACAACCAA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TACTAACCACTCATCGCCGCCATTAACCTGATTGA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TCATCAAGTGGTTTGGCTTGTTGTGTAGCAGCGAA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TTTCTTTCATCTGGCATCATTTAATCTCCCTTCAT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	AAGCCATGTGCTTATCCAGGATGCCCTAAATTAAT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CTAAGATTGGATATTGATGACGAAGAAATGCTAAT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TACCTCCCAGTCTTCTGGAAGGCTCATTATATAAGC
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CAATGCAACAACTTCTCATCCATCTTATGTTGTGC
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	ATATTCCAAGAAATTAAGAGGATAACAGGAAAGGGG
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TACTTTACCTACTTTGTTGTACTTTTTAAGCTCCTG
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	AGTGAGCCTCTCCGTCTTCCCCGACCTTGATAGCTT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	AATGGTAGCTGCTTTTATTGATGATAACAAGCCTGA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CCTATCAGGTTCGCCTTGTTGATACCCTGGTTGCCA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TCAGTTTCCCAAACTAACCTCGTTACTCCTCCAGCCA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	AATTAATTATGAAAAAGAATGGTGTTATTTATTTAA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TGATTCAGCATCGCCACGAAGCAATCCTTCAACAA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TAAGGTGGTGAAGGATTGATGAGATTTAAGTCTTTAA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TTTAATAATTCATTTTCAATTTTTCTTTTTAACTT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	AGAGTGCTAATAACGGAGGAACTGTTGAGCTTACAT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CAAGCTCGTCCCTATTATCATCAAAACCACCTCTGA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TAATAGGGAGTCTTGTGTAGTCAAATACTTTTGAAA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	AGCGAGCCGGCTAACTCATCTATTACTACAGGCAA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CAGATATGATGGCCTGGGCTATACTACACAGGATAT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CACGATTATAACTGCAGAGATCGCAATGGCAATCT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC

>NC_014654|4|1|1666592-1670122|CRT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TTTCAATCTGTAAAGTATAATGTAACTAGGACTTAA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CCTGGCCCGGCTCTACTATTTGCTCTAGTTTACGAAA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CTAAAGATTTTAGCAGCTATGCAAATACAGATTACA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CCAAAATATCTTTTTGCGTTCTCGGCGTTTTTTTC
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CCTTGAGAGTTTTCGAATTGACTTATCTGGTCTTTAA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TCATCATCTTGATCCTGATCGTCCATCTCATCCAGAT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	GAATAACGATGAAGAGCAGACTGATCTCGATCCGAT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	AAGTTCTCCATTTACATCTGGGAAATATCCATTTT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TTTTTGTAGGATTTTATAATGCAATTGGGAAATTTCG
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CTATAACTTCTCGCTGGATAGTTCTACCTAATTCCT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TGTTTTATAACACTTGTCAAAATATTTAAGTTATTT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	ATGATGGACAATTAAAAAAAACTTTTGAATCCTT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CCATTCGTAGTTGTTTTCTATGATAGGAGTATCACAC
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TTATCCATAGACACATAGCCCTCATATGCACCAA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	AGGGTTTATATCGTGGCGAGAGCTACTCAGATATGTC
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TAATATACAGACACCTTTTGCTATGTTAACAAAATA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	AAGCTAGATGTAGGCAGGGTTTTATACTTTAATGCAT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	AATTAAGCAGTAAAGCATGGAATTCACTTTATATGTG
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	ATTGCCATCTGTTATTCCTCCTATATATTCAATATTT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TTAGTTGAAAATTCTTATGCAGCTTCACCTATAT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	AAGATGTTTTAATTGAGAAAGGACAAATGCTAGAAA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CTACTTGACCTTTTTTCATAACTTAACCACCTCCT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TAACAAACATAAGAGGGATAAGGATAATTATGCTCC
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	AAGATAGCTGAAAGCCGAAAGCGTCTACGAGAACA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TCGCAACAAAGTCAGCCCAAACCACCAACAACCAA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TACTAACCACTCATCGCCGCCATTAACCTGATTGA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TCATCAAGTGGTTTGGCTTGTTGTGTAGCAGCGAA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TTTCTTTCATCTGGCATCATTTAATCTCCCTTCAT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	AAGCCATGTGCTTATCCAGGATGCCCTAAATTAAT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CTAAGATTGGATATTGATGACGAAGAAATGCTAAT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TACCTCCCAGTCTTCTGGAAGGCTCATTATATAAGC
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CAATGCAACAACTTCTCATCCATCTTATGTTGTGC
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	ATATTCCAAGAAATTAAGAGGATAACAGGAAAGGGG
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TACTTTACCTACTTTGTTGTACTTTTTAAGCTCCTG
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	AGTGAGCCTCTCCGTCTTCCCCGACCTTGATAGCTT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	AATGGTAGCTGCTTTTATTGATGATAACAAGCCTGA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CCTATCAGGTTCGCCTTGTTGATACCCTGGTTGCCA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TCAGTTTCCCAAACTAACCTCGTTACTCCTCCAGCCA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	AATTAATTATGAAAAAGAATGGTGTTATTTATTTAA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TGATTCAGCATCGCCACGAAGCAATCCTTCAACAA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TAAGGTGGTGAAGGATTGATGAGATTTAAGTCTTTAA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TTTAATAATTCATTTTCAATTTTTCTTTTTAACTT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	AGAGTGCTAATAACGGAGGAACTGTTGAGCTTACAT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CAAGCTCGTCCCTATTATCATCAAAACCACCTCTGA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	TAATAGGGAGTCTTGTGTAGTCAAATACTTTTGAAA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	AGCGAGCCGGCTAACTCATCTATTACTACAGGCAA
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CAGATATGATGGCCTGGGCTATACTACACAGGATAT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC	CACGATTATAACTGCAGAGATCGCAATGGCAATCT
GTTTCAATCCTTATTTTAATGGATTAGTCATTGGAGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_014654.1\|WP_013406002.1\|1677167_1678997_-\|TIGR02556-family-CRISPR-associated-protein	cas8b1	cd09730_cas8b1_CAS-I-B	gnl\|CDD\|378190
NC_014654.1\|WP_013405986.1\|1649411_1650134_-\|MgtC/SapB-family-protein	unknown	unknown	gnl\|CDD\|224204
NC_014654.1\|WP_013405997.1\|1671691_1671982_-\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|187856
NC_014654.1\|WP_013405993.1\|1661837_1663421_-\|alkaline-phosphatase	unknown	unknown	gnl\|CDD\|293736
NC_014654.1\|WP_013405996.1\|1671084_1671675_-\|CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	gnl\|CDD\|187768
NC_014654.1\|WP_013405998.1\|1671981_1672962_-\|CRISPR-associated-endonuclease-Cas1	cas1	pfam01867_cas1_CAS-I:CAS-II:CAS-III	gnl\|CDD\|376633
NC_014654.1\|WP_013406001.1\|1676250_1677165_-\|type-I-B-CRISPR-associated-protein-Cas7/Csh2	cas7	cd09690_cas7_CAS-I-B	gnl\|CDD\|274217
NC_014654.1\|WP_013405988.1\|1651401_1652580_-\|YibE/F-family-protein	unknown	unknown	gnl\|CDD\|377940
NC_014654.1\|WP_013404838.1\|1656628_1657699_-\|IS30-family-transposase	unknown	unknown	gnl\|CDD\|225382
NC_014654.1\|WP_013406003.1\|1679256_1680222_-\|WYL-domain-containing-protein	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|379100
NC_014654.1\|WP_160143108.1\|1670380_1671070_-\|hypothetical-protein	cas6	cls000004_cas6_CAS-I:CAS-III	gnl\|CDD\|379957
NC_014654.1\|WP_013405992.1\|1660528_1661707_-\|YibE/F-family-protein	unknown	unknown	gnl\|CDD\|377940
NC_014654.1\|WP_095522096.1\|1658138_1659406_+\|IS3-like-element-ISHahy4-family-transposase	unknown	unknown	gnl\|CDD\|366234
NC_014654.1\|WP_013405991.1\|1659677_1660508_-\|leucine-rich-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|380193
NC_014654.1\|WP_013406000.1\|1675464_1676184_-\|type-I-B-CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	gnl\|CDD\|131641
NC_014654.1\|WP_160143109.1\|1680736_1683382_-\|HAD-IC-family-P-type-ATPase	unknown	unknown	gnl\|CDD\|319775
NC_014654.1\|WP_013405994.1\|1665305_1666439_+\|hypothetical-protein	unknown	unknown	unknown
NC_014654.1\|WP_013405999.1\|1672986_1675446_-\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|350688
NC_014654.1\|WP_013405987.1\|1650550_1651381_-\|leucine-rich-repeat-protein	unknown	unknown	gnl\|CDD\|380192
NC_014654.1\|WP_013405989.1\|1654400_1655993_-\|alkaline-phosphatase	unknown	unknown	gnl\|CDD\|293736

Protein	Function_ID	Function_description	E-value
NC_014654.1\|WP_013405986.1\|1649411_1650134_-\|MgtC/SapB-family-protein	gnl\|CDD\|224204	COG1285, SapB, Uncharacterized membrane protein [Function unknown].	8.96026e-50
NC_014654.1\|WP_013405997.1\|1671691_1671982_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	5.9626e-19
NC_014654.1\|WP_013406002.1\|1677167_1678997_-\|TIGR02556-family-CRISPR-associated-protein	gnl\|CDD\|378190	pfam09484, Cas_TM1802, CRISPR-associated protein TM1802 (cas_TM1802). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This minor cas protein is found in at least five prokaryotic genomes: Methanosarcina mazei, Sulfurihydrogenibium azorense, Thermotoga maritima, Carboxydothermus hydrogenoformans, and Dictyoglomus thermophilum, the first of which is archaeal while the rest are bacterial.	5.49942e-139
NC_014654.1\|WP_013405996.1\|1671084_1671675_-\|CRISPR-associated-protein-Cas4	gnl\|CDD\|187768	cd09637, Cas4_I-A_I-B_I-C_I-D_II-B, CRISPR/Cas system-associated protein Cas4. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas4 is RecB-like nuclease with three-cysteine C-terminal cluster.	3.75061e-28
NC_014654.1\|WP_013405998.1\|1671981_1672962_-\|CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|376633	pfam01867, Cas_Cas1, CRISPR associated protein Cas1. Clustered regularly interspaced short palindromic repeats (CRISPRs) are a family of DNA direct repeats found in many prokaryotic genomes. This family of proteins corresponds to Cas1, a CRISPR-associated protein. Cas1 may be involved in linking DNA segments to CRISPR.	1.03629e-95
NC_014654.1\|WP_013406001.1\|1676250_1677165_-\|type-I-B-CRISPR-associated-protein-Cas7/Csh2	gnl\|CDD\|274217	TIGR02590, hypothetical_protein_MM_0563, CRISPR-associated protein Cas7/Csh2, subtype I-B/HMARI. This model represents one of two closely related CRISPR-associated proteins that belong to the larger family of TIGR01595. Members are the Csh2 protein of the Hmari subtype of CRISPR/cas system. CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeats. The related model is TIGR02589, the Csd3 protein of the Dvulg CRISPR subtype.	5.52409e-89
NC_014654.1\|WP_013405988.1\|1651401_1652580_-\|YibE/F-family-protein	gnl\|CDD\|377940	pfam07907, YibE_F, YibE/F-like protein. The sequences featured in this family are similar to two proteins expressed by Lactococcus lactis, YibE and YibF. Most of the members of this family are annotated as being putative membrane proteins, and in fact the sequences contain a high proportion of hydrophobic residues.	4.17636e-73
NC_014654.1\|WP_013404838.1\|1656628_1657699_-\|IS30-family-transposase	gnl\|CDD\|225382	COG2826, Tra8, Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair].	2.36473e-63
NC_014654.1\|WP_013406003.1\|1679256_1680222_-\|WYL-domain-containing-protein	gnl\|CDD\|379100	pfam13280, WYL, WYL domain. WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the WYL-like superfamily, named for three conserved amino acids found in a subset of the superfamily. However, these residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by a cysteine, which are predicted to line a ligand-binding groove typical of the Sm-like SH3 beta-barrels. A WYL domain protein (sll7009) is a negative regulator of the I-D CRISPR-Cas system in Synechocystis sp. It is predicted to be a ligand-sensing domain that could bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas and other defense systems such as the abortive infection AbiG system.	1.36703e-51
NC_014654.1\|WP_160143108.1\|1670380_1671070_-\|hypothetical-protein	gnl\|CDD\|379957	pfam17262, DUF5328, Family of unknown function (DUF5328). This family of unknown function can be found in Bacteria and Archaea. Some of the proteins in this family are annotated in UniProt as putative DNA repair proteins.	2.44241e-39
NC_014654.1\|WP_013405992.1\|1660528_1661707_-\|YibE/F-family-protein	gnl\|CDD\|377940	pfam07907, YibE_F, YibE/F-like protein. The sequences featured in this family are similar to two proteins expressed by Lactococcus lactis, YibE and YibF. Most of the members of this family are annotated as being putative membrane proteins, and in fact the sequences contain a high proportion of hydrophobic residues.	2.68372e-75
NC_014654.1\|WP_095522096.1\|1658138_1659406_+\|IS3-like-element-ISHahy4-family-transposase	gnl\|CDD\|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	1.96085e-20
NC_014654.1\|WP_013405991.1\|1659677_1660508_-\|leucine-rich-repeat-domain-containing-protein	gnl\|CDD\|380193	NF033189, internalin_A, class 1 internalin InlA. Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface or secreted proteins with an N-terminal signal peptide, leucine-rich repeats, and usually a C-terminal LPXTG processing and cell surface anchoring site. See PMID:17764999 for a general discussion of internalins. Members of this family are internalin A (InlA), a class 1 (LPXTG-type) internalin.	5.3496e-33
NC_014654.1\|WP_013406000.1\|1675464_1676184_-\|type-I-B-CRISPR-associated-protein-Cas5	gnl\|CDD\|131641	TIGR02592, hypothetical_protein_CTC_01466, CRISPR-associated protein Cas5, subtype I-B/HMARI. This is a CRISPR-associated protein unique to the hmari subtype of cas genes and CRISPR repeat, which is the only subtype present in Haloarcula marismortui ATCC 43049. The hmari type, though uncommon, is also found in the Aquificae, Thermotogae, Firmicutes, and Dictyoglomi.	8.31244e-40
NC_014654.1\|WP_160143109.1\|1680736_1683382_-\|HAD-IC-family-P-type-ATPase	gnl\|CDD\|319775	cd02080, P-type_ATPase_cation, P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, and Synechocystis sp. PCC 6803 PMA1, a putative Ca(2+)-ATPase. This subfamily includes the P-type Na(+)-ATPase of an alkaliphilic bacterium Exiguobacterium aurantiacum Mna and cyanobacterium Synechocystis sp. PCC 6803 PMA1, a cation-transporting ATPase which may translocate calcium. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NC_014654.1\|WP_013405993.1\|1661837_1663421_-\|alkaline-phosphatase	gnl\|CDD\|293736	cd16012, ALP, Alkaline Phosphatase. Alkaline phosphatases are non-specific membrane-bound phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH. Alkaline phosphatase exists as a dimer, each monomer binding 2 zinc atoms and one magnesium atom, which are essential for enzymatic activity. Mammalian alkaline phosphatase is divided into four isozymes depending upon the site of tissue expression. They are Intestinal ALP, Placental ALP, Germ cell ALP and tissue nonspecific alkaline phosphatase or liver/bone/kidney (L/B/K) ALP.	3.85887e-105
NC_014654.1\|WP_013405999.1\|1672986_1675446_-\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|350688	cd17930, DEXHc_cas3, DEXH/Q-box helicase domain of Cas3. CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	1.59393e-47
NC_014654.1\|WP_013405987.1\|1650550_1651381_-\|leucine-rich-repeat-protein	gnl\|CDD\|380192	NF033188, internalin_H, InlH/InlC2 family class 1 internalin. Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface or secreted proteins with an N-terminal signal peptide, leucine-rich repeats, and usually a C-terminal LPXTG processing and cell surface anchoring site. See PMID:17764999 for a general discussion of internalins. Members of this family are internalin H (InlH), or internalin C2, two class 1 (LPXTG-type) internalins that are closely related, one apparently derived from the other through a recombination event.	1.94147e-32
NC_014654.1\|WP_013405989.1\|1654400_1655993_-\|alkaline-phosphatase	gnl\|CDD\|293736	cd16012, ALP, Alkaline Phosphatase. Alkaline phosphatases are non-specific membrane-bound phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH. Alkaline phosphatase exists as a dimer, each monomer binding 2 zinc atoms and one magnesium atom, which are essential for enzymatic activity. Mammalian alkaline phosphatase is divided into four isozymes depending upon the site of tissue expression. They are Intestinal ALP, Placental ALP, Germ cell ALP and tissue nonspecific alkaline phosphatase or liver/bone/kidney (L/B/K) ALP.	1.32691e-109

>NC_014654.1|WP_013405994.1|1665305_1666439_+|hypothetical-protein
MNSQLKNAIINHQQEKVKQILKELKNDPRFSLVSLIDDLLPLMLMESNLSYGSFHFVKMSLFLKELLQKKYLSREAELEISKVVILGLSERHFINIKADSSGYKEKEVKQKSYDKLTEEINNGNSHNAFYYALGLLEKQPKGLKKHLLNLGMERIPDSLGHSVSCFFPVMRDIVNHHDDLAATAVLSYIMYLARYNYQEKYISKQEKTEKPSLDDLEDLGLKAVSGSGIVNLHHMITYYTFFMLEDSSFYQPLPPYSILKNYFGNKNIDQKRLKLIEINKKETQIAESYQEFKNNFTLSNYQDGLSFLFYNLNNNFKNTNSYLYQLFAEYYNPNWNPHYYTGLYCALGLYRSAKINDKKIKKMAVIQAIEYFVSNVL
>NC_014654.1|WP_013405993.1|1661837_1663421_-|alkaline-phosphatase
MSLKRTLKIGLATLVILIAALVFMPVQTEAQEVEHVFFFIGDGLGNAQATLTEYYLQDKYDDPDYELNMHRLDEMAVTTTYGADKVVPGSAQTATALASGHKTNFGYVGVTTDHEPTTTIMDKARENDWGTGLVTTTRVTHATPAAFASHVPDRGMENEIIEHYLEKEVDVIAGGGYRHLYPEDHPDSTRTDDRNMYAEFAEAGYNTFEGPADVDEFRDFDPEGRERILAGFHPTHMSYEIDRDSAEEPSLAEMTDISLNTLEEYGEFMMVIEGGRIDHAAHNNDPGGMIYDTIAFDEAIGVALEFYEENPDNTLIIVAGDHETGGLGLNSCEGMEYGYYLDFEPVFAQEASIEEGIAFEDEEQWYQDIADKFGLDELTPREQDWMEHGVAIEEEYGHEADVGRPGRVGGVYDGGQDYDVPYDDDALTEEMAAHWPQAPWISPAQSTLAHIVSRRAKIGWNTSSHTGSAIQLTAHGAGASNYEGRLDNTDVATITAGLLDFELDPEVGVAEIEEEESRNLLRRIFGR
>NC_014654.1|WP_013405992.1|1660528_1661707_-|YibE/F-family-protein
MSKKLLLNKERMISLIIGLILIAIFAGFYFHQPGDEEFSREARGVVLETDDRDVQGSGITRFGNQFVEVELKEGKFQGQQIRATNQLVGSLAWDYSFSEGEEIVVGLFETPEGELEGAIALDVYRQNWTFILVAFFVLLLLLYAGYTGLRALISFAGSVYIIWNLLIPGLLDGLNPLYFSGFVLVILSALIVFSIAGFTKKGISAFVGTVSSLIITIGIVVFFGNRLALDGMSVPYVGEVLFAGYMHLNIRDIFFATVVIGASGAAMDIAMDMAATIEEIKLRKPDISFFELAKSGFNVGSAVIGTMTTTLLLAYIGSYMTLFMAFMTREASFVRIMNLRLIVSEILRTLTGSIGIVLVAPITTIFAAWIYSIETDFSLFGIKDYFFSKKED
>NC_014654.1|WP_013405991.1|1659677_1660508_-|leucine-rich-repeat-domain-containing-protein
MRKKLLFLIACLSIVLLVSGCGIMRGEEAEFEDPNLEAAVRENIDKSSGAIYQDEIKDIKELHAVSKGIESLEGIDNLVALETLILSQNQIEDLSPLVELEDLKELNIQRNNIADITPLAELDKLEVLNLENNNLTDINPLGEVSNLKSLNLSNNHLSDITEIAELNDLERLVLDRNEIEDISSLAQLNNLTELYFVHNQVEDISPLAEITNLESLTFGYNNVSDISPLVENEGLGQGDFINFEENKLDYSEGSEDMENINILLDRNIQLIYRRMY
>NC_014654.1|WP_095522096.1|1658138_1659406_+|IS3-like-element-ISHahy4-family-transposase
MANRKYSDETKEQIVKECREIGNTALVARRHNISKHTVYSWVKKAKETGSVRSLPKDEKKQMKEIENRLSKMSDENDKLKKIVAEKELELAILRELRDKVKPPIALKVQIASKWINKGYKISIVLDFVGLNSSTYYSNINRKTESESTNSSNSNNPQGRPVPGYSLTESGEKISDEQIKEWLLELVAGDGFPYGYRKLTVCLKEDYNLKINKKKVYRLCKELDILRSQRKIKKFRPKKIAKQEEITEPNQLWQMDLKYGYINGTDQFFFQMSVIDVFYKTVIDYHLGLSCKAKDTCRVLKAALNKRKLYKGMNLPKIRTDNGPQFVSKLFGDTCEKLGVEHQRIPVRTPNMNAHIESFHSVLEKDCYSINEFSSFIDAYKKVSEYMNYYNNRYRHGSLNDMPPAKFYKLAKAEKIVAEPVLA
>NC_014654.1|WP_013404838.1|1656628_1657699_-|IS30-family-transposase
MCQSNCNTKRSKGKHLNFDDRKLIKHLYNVQEKNYTEIGEELNCHRTTISREIKKGEVELDNGDGTTRKEYVPEIAQKVYEFNNSNKGPDLKIDKNKELAEFIEEKIKELRSPAAVAKDIEESDKFEIQLHWKTIYNYIDKGVLNIDRSDLPHGNYKTGKDRPKESESTTRRKEGRTIRDRPEGADTREEFGHWEMDLVEGLKQKDEPALLVLTERQTRQEIIEKIPNKKAKSVVKGLDRIERRFGVVNFRETFKSITTDNGSEFADYEGIEQSYTGSSIPRTSLYYCDAYCSWQRGSNEVANKFIRRFLPKGTSFKGIKRKLIKKIQDFINTYPRKMFNYENSDKLFKEKLSFSV
>NC_014654.1|WP_013405989.1|1654400_1655993_-|alkaline-phosphatase
MSAKRILKLSLATLVMFVSVFAALAFAPVQTEAQEVEHVFFFIGDGLGNAQSTLTEYYLQAKYDDPDFRLNMNKLDEMAITTTYGADKVVPGSAQTATALASGHKTNFGYVGMTTDHKPTTTIMDRARENDWGTGLVTTTRITHATPAAFASHVPDRGMENEIIEHYLEKEVDVIAGGGYRHLYPQDHPASSRTDDRNMYAEFTAAGYNIFEGPADVEKFRNFAPEGRERLLAGFHPTHMSYEIDRDPAEEPSLAEMTKVALNTLENYGKFMMVIEGGRIDHAAHNNDPGGMIYDTIAFDEAIGVALEFYEENPDNTLIIVAGDHETGGLGLNSCEGMEYGYYLNFEPIFAQNASIEEGIAFENEEQWYQDIADKFGLDELTPREQAWMEHGVAIEKEYGREADVGRPGRIGGVYDGGQDYDVPYDEEAMRDVMYAHWPQAPWISPAQSTLAHIVSRRAKIGWNTSSHTGSAIQLTAHGAGASNYEGRMDNTDVAKITAALLDFELDPEVGVAEIEVAESRNLLRRIFGR
>NC_014654.1|WP_013405988.1|1651401_1652580_-|YibE/F-family-protein
MSKKLLLNKERMISLIIGLILIAILAGFYFHRPGDEEFSREARGVVLETDDRDVQGSGITRFGNQFVEVELKDGKFQGQQIRATNQLVGSLAWDYSFSEGEEIIVGLFETAEGQIAGAIALDVYRQNWTFILMAFFMLLLLLYAGYTGLRALISFAGSVYIIWNLLIPGLLDGLNPLYFSGFVLVILSALIVFSIAGFTKKGISAFVGTVSSLFITIGVVVFFGNRLALDGLSVPYVGEVLFAGYMHLNIRDIFFATVVIGASGAAMDIAMDMAATIKEIKLRKPDISFFELAKSGFNVGSAVIGTMTTTLLLAYIGSYMTLFMAFMTREASFVRIMNLRLIVSEILRILTGSIGIVLVAPITTIFAAWIYSIETDFSLFGIKDYFFSKKED
>NC_014654.1|WP_013405987.1|1650550_1651381_-|leucine-rich-repeat-protein
MRKKLLFLIACLSIVLLVSGCGIMRGEEAEFEDPNLEAAVRENIDKSSGAIYQDEIKDIKELHAVSKGIESLEGIDNLVALETLILSQNQIEDLSPLVELEDLKELNIQSNNIADITPLAELDKLEVLTLGDNRINDISPLKELSNLKSINLSNNQLTNISEIAKLKDLERLILDRNQIKDISPLIKLDNLKELFFVHNQVEDISPLAEIAALEILSFGYNNVSDISPLVENEGLGQGDFINFEGNHLDYSEGSEDMENINILLDRNIQLLYRRMY
>NC_014654.1|WP_013405986.1|1649411_1650134_-|MgtC/SapB-family-protein
MEIWEFVIRLLVALMAGVIIGVEREWRKRMAGIRTNTLVALGAALYVLFSMMFPEESSPTRVGASIVSGIGFLGGGVIIKKGFSISGLNTAATLWCSAATGVLAGAGYLKEAIIGALVVLISHLGLRYFQEKFVGKHNNFRDSECKITIIFNDSDLREGTSCLEKIAKESGGNIKHISSNFIQDDVLKITAYLQIKGIDVKMLYDLIAKYSKHKKIDNIELEIDEFSTDFKANNAREESS
>NC_014654.1|WP_160143108.1|1670380_1671070_-|hypothetical-protein
MEIKTTKLNYELEDKLPVRYGHKLRGFFANEFDDILFHQHKKDGSLRYQYPLIQYKIIDNKPLIIGLGDGAEKIINNFLEVEKLRLDNKIYHSPASRLKVDNEELFVNTDYDMPSYKYTFLTPWLGLSQKNYKKYIQNYIDAKTDKKMKFLKRLIIGNILSFAKGINWWIEEKIILEAKLEDISVQFKNEEMVGFKGHFYSNIYLPELIGLGKSTSRGFGTIRRKNLFD
>NC_014654.1|WP_013405996.1|1671084_1671675_-|CRISPR-associated-protein-Cas4
MSKEISLTPSVVMEYLYCPRFIYYMLYLKISQHEGRRYKVQRGKSSHQKKSKINKSYLRKKIGVEKKIINEKLYSEKYNIHGIVDEILFLNDGTAASLDYKFAKYKKRTFLTHKYQAAMYSLLIRDNYNIQVNKAFIIYIRSKNKLIEIDIGEDVYSELQTIFNEIIDIIKKGYFPKRTNYKSRCRDCTYRNICIK
>NC_014654.1|WP_013405997.1|1671691_1671982_-|CRISPR-associated-endonuclease-Cas2
MLVWCIYDIVEDKPRKKIADKAIEQGLYRVQKSVFAGNIDSNLLDELIVYSEDLINLDEDSVYIFPMCQEDFKKIELIGQAFNKAMVNDELKSLFG
>NC_014654.1|WP_013405998.1|1671981_1672962_-|CRISPR-associated-endonuclease-Cas1
MQLIINTYGSYLHVEQSSFEIKADDKKKRVSAKKVDSILITTGAAISSDAVKLALENNIEIQFLDHFGRSMGKVWHSKLGSTTYIRRRQLELADSEEGTEIIKEIMIEKAENMIKHLYDLGIKRGEEKQNYLFETIEEMEKIKDKIPKLTGPVEIMRNSIMGYEGNISKRYFNALNYLLPDRYKFGKRTFRPAEDEFNCLLNYGYGVLYGKVEKALIIAGLDPYVGILHTDGYNKKSFVFDFIEIYRHHIDRIVMKLFSRKKVRKSYFDQIKGGVTLNKKGKEIFLTALNKYFDESIYYKGRQIKVNNTIQYDSHNLANRIIEEGD
>NC_014654.1|WP_013405999.1|1672986_1675446_-|CRISPR-associated-helicase/endonuclease-Cas3
MLYSHPEKFLIDHLNNVYMLGKEIFARKKLNFANLAEIEKALSIILLTHDFGKATDYFQIKLEKSSFGNKLSNKEGEFNQELSKHSHISSLLAYQFADQILEDDILVWIVFITVYRHHSNFKDLDNMLKFDESDWPKLRKQFEALDFNELDSISVEISDFDFKPSSIDFDDLKNKFTNWRFRKNLRTFKNKPNKDFNYYLISNLLFSILIFADKAEAIFYSKGYSFKDLKEVALNRSDLPDDLVNNYRNLKGWNQPDSKINIKRNQIYDEVVNQIENINIENERILSINVPTGAGKTLSVFSAALKLRNKISQDFRIIYALPFTSIIDQNYDVFLDVLNHSDMKVDSTKIIKHHYLNAKNYYLNEEDKESQKLDYDISKHLIESWQSEIVVTTFVQLLHSIFSNRNRSLIKFNNICNSIIILDEVQNIPHKYWKLIKEFLSDMAKKLNCYFIFLTATMPLIYNEKEQEIKELATSKRDYFKFFDRINLDTTMFKQPLTLEQFKDFIEEEFIEFYDRSFLIILNTIKSSIHIFNYIEKLINEEIINGELIYLSSNIIPKERQKRIKKIGKKKRQIIVSTQMVEAGVDIDLDRVYRDFAPLDSINQSCGRCNRNFDPENRGTVKLFRLVNENHNNKDYASYIYDNFLLKITSDIITELPEIVRENDFFEMNQKYFNKINELKSNDNSETLISKIKNLKYEKSFFKDEKEEIFRLITDDYNTVNLFMAVDEDAEELWEEYKEISGLESYNIEEFMLKKAKFENIKKEFLSYVITIPKFTAEKHLGDEQLKNNFNYISPFQIEDVYNLNTGFKRREIETETFF
>NC_014654.1|WP_013406000.1|1675464_1676184_-|type-I-B-CRISPR-associated-protein-Cas5
MNKALVFDIWADYAHFKKYYTTTSPLTFSIPPKTTLYGIISAILGFSKEEYLKKFNEGLCKIAIQIKNPVNKTRINLNLIDTKKAALMSQIETRTQIKTEFLKDAKYRIYFMHQDEDLYNNLKEKLKNHKTVYSISLGLSENLANFKYIEEIEVEKINENSWQEINTVMRIDTENISKGDIDFSQNGREYFSDKIAVEMKSDRTVTDYAQVLFEKNGKSIKVNVNKYYKDSNNNRLLFL
>NC_014654.1|WP_013406001.1|1676250_1677165_-|type-I-B-CRISPR-associated-protein-Cas7/Csh2
MAIIDQRSEIVFLYDIKDANPNGDPLDANKPRIDEETGINLVTDVRLKRTIRDYLFDYKGFNGEDGKDIFVREIKNDDQSIQDGKERAKDFKENPKKVLDQCIDVRMFGGVIPLTGDSITYTGSVQFQMGRSLHKVELNYIKGTGAFASGSGKTKKTFREEYVVPYSLVGFYGIINENAAQSTKLTQDDVELLLEGIWKGTKNLITRSKVGQTPRLLLKVNYSEENYFIGELKSYINLNTDLREEEIRDVSDYSLDISDLLAVIETNSEKIDSVEYKVNPRVEFISDSKRINLNDLELFKELNI
>NC_014654.1|WP_013406002.1|1677167_1678997_-|TIGR02556-family-CRISPR-associated-protein
MIHALKVMGDYVQDKTESSFLSQVVENPNSNGKYNTVLVVLFNNDAELKYQEIQMEEFTKKKLDKYAYVYGNPRGGDLTPTSKITKLESTYSRIQRPLKKLVNKIKKQDELNQEEETIIEIFNLFQDEELKDKIYQELEVISYDDNAVLTIALQENDQIKYVGDFNKFTESLLDNYEKGFYFKKSYNKAEKNSVGKNNKCYICSKEKDKTYGYVGTFAFYTLDKPGFTTGGFNRGESWKNYPVCSDCARTLDLGKKYLEENLSSRFSGINYFIIPKTIFASETETEEMFEILGDLEDKKKLSLEKENKKSLSGSQNDLFQMMSEFKNYVNFNIMFYEEINSAFRILLYVEDVLPSYIQKIFAAKDKIDKDELFVNLQGKDGPFKLSFTFNTISNFFYVNQRGKQDFTKFFLEITNNIFSEKKVSYDLLINRFIYHIREKFINSQSYWLDNLKALQILKFLNKLDLLNQNGKEEKSMPTVDSEYKKNIVDFLDEHNDVLNSNSKKLVFLEGVLAQKLLNIQSSERDGSNPFRARLNGLKLNEKIIKRLYTEIINKLEEYDKNYYKQLEELIADYILESNLSEISNNEISFYFVTGMNQANKFNFQKSEEE
>NC_014654.1|WP_013406003.1|1679256_1680222_-|WYL-domain-containing-protein
MADTNRIFRIIKMIMLLNEPYKHWEAKDFADYFNISERTFHWDKRVMEELGVPIYYDNHLKEYKILDNFRFKAPNLDQKETEAVLLAAKEYQNRSFPMKKELESGLAKVYNSLPEFLKNSMSGYIKNYEIISEPFVELEEYQQKFELLKKAMNEEKKIIIDYYSMSSDRTTQRKLDPYNLFFNNGAPYLYAFCHLRDEKRMFRIDRIKKLQLTEEKFELPDNFSLSDELQNSWGVEQGKKEMEVKIKFSGKTARFVPEYRWNDQQEIEEISENEIIFNVKTTSREEIKKWVLGYGSEAEVLSPQDLRAEIQQEIEKMLENY
>NC_014654.1|WP_160143109.1|1680736_1683382_-|HAD-IC-family-P-type-ATPase
MENTLKKFETSKNGLSKKETVERLDNFGKNKLPSPAQKHPVLKFLSHYNNVLIYVLFAAAIVTALLGHWIDTIIILAVVVINGLISYIQEGKAEKALDAVKNMLSTTARIKREGEIREITAEEVVIGDIIYLKPGDKVPADLRLIESKNLSINEASLTGESVPASKKTEIFKQELALGDRKNMAYSSTIVTSGEGIGVVVATGKDTEIGRINQMISSVEKLKTPLIQQVDRFGKQLTLFILSLGFLVLLIGRFLRGTPFDELFLSVVGIAVAAIPEGLPAVITITLAIGVQRMAARNAIIRKLPAVETLGSVSIISSDKTGTLTEGEMTVKTVVTADKDYTISGNGYDPSGKLINKEKEVDLSKESVLKELLKNASLNNDARLVQKENNWIIEGSPTEGALKTLVAKSSYDNKTLAKNNPRLDSIPFNSDKKYMATLNQGDNNNIIYLKGAPEVVLDMCGEQLTEAGSKKLDKDYWGKRQDELASNGYRLLALAYKKIDKNTKELSLDHIQSEMIFLGIIGVMDPPRKEAIEAVKECQEANIKVKMITGDHATTASAIAAQLGIENPSEVITGNEINNLDDIELKEVIEKTYVFARVSPEHKLRLVTAMQELGYITAMTGDGVNDAPALKKSDIGVAMGINGTEATKEAAEMVLADDNFASIINAVEEGRTVYDNLKKALLFMLPTNGGEALVIMAAVLFGFSLPITPVQILWINMITAVTLALTLAFEPMEEDAMKRPPRDTGESLTPFSLLLRIGFVSVILTATTLGIYTWAISNDLALPLARSLAVNMLVYGEIFYLFNSRYMTKSSLNLKGFKATPWVWKAVGAVVVLQFMFVYFTPIQTIFDVAPLNLSHWLIIIGVNCLLFLVVELEKYISRNFY

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Crispr_ID: NC_014654_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014654_5

2151542-2151626

Orphan

Consensus_repeat	Method
CACTGAATCTTCTTTAATAGAACAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014654_5

>merge|NC_014654|5|2151542-2151626|CRISPRCasFinder
CACTGAATCTTCTTTAATAGAACAAAAAGGATGATTCAGCACTTGGACATTGAGTCCGTCGCACTGATCTTCTTTAATAGAACAA

>NC_014654|5|5|2151542-2151626|CRISPRCasFinder
CACTGAATCTTCTTTAATAGAACAA	AAAGGATGATTCAGCACTTGGACATTGAGTCCGTC
GCACTGATCTTCTTTAATAGAACAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_014654.1\|WP_013406430.1\|2135038_2135830_-\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|378112
NC_014654.1\|WP_013406444.1\|2155726_2156500_-\|type-III-pantothenate-kinase	unknown	unknown	gnl\|CDD\|237347
NC_014654.1\|WP_013406441.1\|2152527_2154003_-\|lysine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234778
NC_014654.1\|WP_013406445.1\|2156513_2157455_-\|nitronate-monooxygenase	unknown	unknown	gnl\|CDD\|240081
NC_014654.1\|WP_013406442.1\|2154099_2154582_-\|transcription-elongation-factor-GreA	unknown	unknown	gnl\|CDD\|234693
NC_014654.1\|WP_013406440.1\|2152041_2152443_-\|YjbQ-family-protein	unknown	unknown	gnl\|CDD\|376651
NC_014654.1\|WP_013406439.1\|2145460_2145928_-\|CtsR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|226869
NC_014654.1\|WP_013406436.1\|2141429_2143883_-\|ATP-dependent-Clp-protease-ATP-binding-subunit	unknown	unknown	gnl\|CDD\|223616
NC_014654.1\|WP_013406437.1\|2143902_2144931_-\|protein-arginine-kinase	unknown	unknown	gnl\|CDD\|234894
NC_014654.1\|WP_013406434.1\|2138175_2138676_-\|CarD-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224248
NC_014654.1\|WP_013406438.1\|2144911_2145457_-\|UvrB/UvrC-motif-containing-protein	unknown	unknown	gnl\|CDD\|226397
NC_014654.1\|WP_013406447.1\|2158584_2159439_-\|biotin--[acetyl-CoA-carboxylase]-ligase	unknown	unknown	gnl\|CDD\|223417
NC_014654.1\|WP_041596047.1\|2154741_2155719_-\|tRNA-dihydrouridine-synthase-DusB	unknown	unknown	gnl\|CDD\|129820
NC_014654.1\|WP_013406433.1\|2137056_2138142_-\|TRAM-domain-containing-protein	unknown	unknown	gnl\|CDD\|227292
NC_014654.1\|WP_160143068.1\|2159511_2160141_-\|folate-family-ECF-transporter-S-component	unknown	unknown	gnl\|CDD\|275311
NC_014654.1\|WP_013406432.1\|2136350_2137040_-\|2-C-methyl-D-erythritol-4-phosphate-cytidylyltransferase	unknown	unknown	gnl\|CDD\|234670
NC_014654.1\|WP_013406446.1\|2157585_2158557_-\|BMP-family-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380577
NC_014654.1\|WP_013406435.1\|2138793_2139873_-\|DNA-integrity-scanning-protein-DisA	unknown	unknown	gnl\|CDD\|237395
NC_014654.1\|WP_013406431.1\|2135816_2136350_-\|2-C-methyl-D-erythritol-2,4-cyclodiphosphate-synthase	unknown	unknown	gnl\|CDD\|376811
NC_014654.1\|WP_013406449.1\|2160273_2161944_-\|formate--tetrahydrofolate-ligase	unknown	unknown	gnl\|CDD\|376511

Protein	Function_ID	Function_description	E-value
NC_014654.1\|WP_013406430.1\|2135038_2135830_-\|CBS-domain-containing-protein	gnl\|CDD\|378112	pfam09021, HutP, HutP. The HutP protein family regulates the expression of Bacillus 'hut' structural genes by an anti-termination complex, which recognizes three UAG triplet units, separated by four non-conserved nucleotides on the RNA terminator region. L-histidine and Mg2+ ions are also required. These proteins exhibit the structural elements of alpha/beta proteins, arranged in the order: alpha-alpha-beta-alpha-alpha-beta-beta-beta in the primary structure, and the four antiparallel beta-strands form a beta-sheet in the order beta1-beta2-beta3-beta4, with two alpha-helices each on the front (alpha1 and alpha2) and at the back (alpha3 and alpha4) of the beta-sheet.	4.44229e-38
NC_014654.1\|WP_013406444.1\|2155726_2156500_-\|type-III-pantothenate-kinase	gnl\|CDD\|237347	PRK13318, PRK13318, type III pantothenate kinase.	1.22918e-135
NC_014654.1\|WP_013406441.1\|2152527_2154003_-\|lysine--tRNA-ligase	gnl\|CDD\|234778	PRK00484, lysS, lysyl-tRNA synthetase; Reviewed.	0
NC_014654.1\|WP_013406445.1\|2156513_2157455_-\|nitronate-monooxygenase	gnl\|CDD\|240081	cd04730, NPD_like, 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase family that reduce a range of alternative electron acceptors. Most use FAD/FMN as a cofactor and NAD(P)H as electron donor. Some contain 4Fe-4S cluster to transfer electron from FAD to FMN.	6.377e-68
NC_014654.1\|WP_013406442.1\|2154099_2154582_-\|transcription-elongation-factor-GreA	gnl\|CDD\|234693	PRK00226, greA, transcription elongation factor GreA; Reviewed.	3.90819e-72
NC_014654.1\|WP_013406440.1\|2152041_2152443_-\|YjbQ-family-protein	gnl\|CDD\|376651	pfam01894, UPF0047, Uncharacterized protein family UPF0047. This family has no known function. The alignment contains a conserved aspartate and histidine that may be functionally important.	1.49722e-61
NC_014654.1\|WP_013406439.1\|2145460_2145928_-\|CtsR-family-transcriptional-regulator	gnl\|CDD\|226869	COG4463, CtsR, Transcriptional repressor of class III stress genes [Transcription].	1.26105e-47
NC_014654.1\|WP_013406436.1\|2141429_2143883_-\|ATP-dependent-Clp-protease-ATP-binding-subunit	gnl\|CDD\|223616	COG0542, clpA, ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones].	0
NC_014654.1\|WP_013406437.1\|2143902_2144931_-\|protein-arginine-kinase	gnl\|CDD\|234894	PRK01059, PRK01059, ATP:guanido phosphotransferase; Provisional.	3.01312e-136
NC_014654.1\|WP_013406434.1\|2138175_2138676_-\|CarD-family-transcriptional-regulator	gnl\|CDD\|224248	COG1329, COG1329, Transcriptional regulators, similar to M. xanthus CarD [Transcription].	2.36851e-53
NC_014654.1\|WP_013406438.1\|2144911_2145457_-\|UvrB/UvrC-motif-containing-protein	gnl\|CDD\|226397	COG3880, COG3880, Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms].	3.2344e-37
NC_014654.1\|WP_013406447.1\|2158584_2159439_-\|biotin--[acetyl-CoA-carboxylase]-ligase	gnl\|CDD\|223417	COG0340, BirA, Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism].	6.061e-54
NC_014654.1\|WP_041596047.1\|2154741_2155719_-\|tRNA-dihydrouridine-synthase-DusB	gnl\|CDD\|129820	TIGR00737, Probable_tRNA-dihydrouridine_synthase, putative TIM-barrel protein, nifR3 family. This model represents one branch of COG0042 (Predicted TIM-barrel enzymes, possibly dehydrogenases, nifR3 family). This branch includes NifR3 itself, from Rhodobacter capsulatus. It excludes a broadly distributed but more sparsely populated subfamily that contains sll0926 from Synechocystis PCC6803, HI0634 from Haemophilus influenzae, and BB0225 from Borrelia burgdorferi. It also excludes a shorter and more distant archaeal subfamily.The function of nifR3, a member of this family, is unknown, but it is found in an operon with nitrogen-sensing two component regulators in Rhodobacter capsulatus.Members of this family show a distant relationship to alpha/beta (TIM) barrel enzymes such as dihydroorotate dehydrogenase and glycolate oxidase. [Unknown function, General].	9.3718e-129
NC_014654.1\|WP_013406433.1\|2137056_2138142_-\|TRAM-domain-containing-protein	gnl\|CDD\|227292	COG4956, COG4956, Integral membrane protein (PIN domain superfamily) [General function prediction only].	1.22798e-128
NC_014654.1\|WP_160143068.1\|2159511_2160141_-\|folate-family-ECF-transporter-S-component	gnl\|CDD\|275311	TIGR04518, conserved_hypothetical_protein, ECF transporter S component, folate family. Members of this model are the multiple membrane-spanning S (specificity) component of ECF (energy coupling factor) type uptake transporters. All seed members were found in the vicinity of the bifunctional enzyme folC, involved in making active cofactor from imported folate. However, some species have multiple members of this family, suggesting some diversity of function. [Transport and binding proteins, Unknown substrate].	4.03018e-33
NC_014654.1\|WP_013406432.1\|2136350_2137040_-\|2-C-methyl-D-erythritol-4-phosphate-cytidylyltransferase	gnl\|CDD\|234670	PRK00155, ispD, D-ribitol-5-phosphate cytidylyltransferase.	1.97237e-91
NC_014654.1\|WP_013406446.1\|2157585_2158557_-\|BMP-family-ABC-transporter-substrate-binding-protein	gnl\|CDD\|380577	cd06354, PBP1_PrnA-like, periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea. Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea. The PnrA lipoprotein, also known as Tp0319 or TmpC, represents a novel family of bacterial purine nucleoside receptor encoded within an ATP-binding cassette (ABC) transport system (pnrABCDE). It shows a striking structural similarity to another basic membrane lipoprotein Med which regulates the competence transcription factor gene, comK, in Bacillus subtilis. The members of PnrA-like subgroup are likely to have similar nucleoside-binding functions and a similar type 1 periplasmic sugar-binding protein-like fold.	1.28282e-59
NC_014654.1\|WP_013406435.1\|2138793_2139873_-\|DNA-integrity-scanning-protein-DisA	gnl\|CDD\|237395	PRK13482, PRK13482, DNA integrity scanning protein DisA; Provisional.	0
NC_014654.1\|WP_013406431.1\|2135816_2136350_-\|2-C-methyl-D-erythritol-2,4-cyclodiphosphate-synthase	gnl\|CDD\|376811	pfam02542, YgbB, YgbB family. The ygbB protein is a putative enzyme of deoxy-xylulose pathway (terpenoid biosynthesis).	3.12737e-87
NC_014654.1\|WP_013406449.1\|2160273_2161944_-\|formate--tetrahydrofolate-ligase	gnl\|CDD\|376511	pfam01268, FTHFS, Formate--tetrahydrofolate ligase.	0

>NC_014654.1|WP_013406439.1|2145460_2145928_-|CtsR-family-transcriptional-regulator
MPSLSDQIEKYLRRQIQKYQGKVKIKRNQLAENFDCAPSQINYVLDTRFTVENGYVVESQRGGGGFIRIIEVTLDSDKEVIQNVISKLNGPISQREANGIIKRLYDNNLISKREYYLMEMAVHRNVLNISLPERDHLRGRILKNMLEVIFKLKEE
>NC_014654.1|WP_013406438.1|2144911_2145457_-|UvrB/UvrC-motif-containing-protein
MLCDNCQETDAVVHLTRIINGEKEEIHLCEDCAKKSNKFNLDSFDNISFQSMLSAVLNDNKSSDNSFMHNKLNNNKKCNSCALNYHEFTKSGEFGCADCYLEFEDDLETLFKRIHGNKRHTGKRPANIEEKKEYQEEINRLKAEMESAVEEERFEDAAEIRDKIHEIKKSMKEDIDESKNI
>NC_014654.1|WP_013406437.1|2143902_2144931_-|protein-arginine-kinase
MNQKIFDNNWLIESGNEKDVVLISRIRLARNLKEFNFPNKATLSEKEKIIDELQNNLNFLKDKNFHLFKMEEFSSLERDVLHEKNLISKCHSENIEGTALILNNKLHLSTMVNEEDHLRIQVFGSGLDFTTIWQIADQFDDQIESEVEYAFSNKWGYLTSCPTNVGTALRASVMCHLPALVLSDRINEVLGAVGKFGLTVRGVFGEGSGSAGELFQISNQVTLGYSEKEIIDNLKSIILQIIREERRTRLYLVNKNYDKLKDNVLRSLGILKYAHSLKENEALNFLSKVKFGLDSGLIEEEINKNAFSELIFKIRTAHLQLNNYNNKEQLNIKRAELIRNSL
>NC_014654.1|WP_013406436.1|2141429_2143883_-|ATP-dependent-Clp-protease-ATP-binding-subunit
MFAKFTERARKVLSIAEQEALKLKHSYVGTEHILYGLIAEGQGIAARALIDNGISRDIVENKIEDMIGKGQNEVKGSIGLTPRSKKVLNLAMDEARKMGHNYIGTEHLLLGLIREGEGVAVRILMDLNSDIKNIKEEVVDLLGGKNAVQKKSKSSNRKTKNLDEYSRDLTDMARENKLDPVIGRDKEINRVIQVLSRRTKNNPVLIGEPGVGKTAIIEGLAQMIVSENVPDLLLNKRVVSLDLSSLVAGSKYRGEFEQRLKAVMNEIIESGEIILFIDEMHTLVGAGAAEGAIDAANILKPALARGELQAVGATTLDEYRKYIEKDAALERRFQSVLVEENSVEEAIDILKGLRDPYEAHHKVEITDRAIEDAVVLSHRYISDRFLPDKAIDLIDEAASKVRLSNSTRPPEFKELSRKLEEAEKEKEAAVKNQEFEKAARMRDKEKKLKKELEELKNSWENEKGKAEAVVTTEDIAEIVSSWTGIPVTKLEEAETARLLRLEEELHKRVIGQDEAITAVSEAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELAKTLAETMFNDEDAMIRVDMSEYMEKHSVSRLVGSPPGYVGHDEGGQLTEPVRRRPYSVVLFDEIEKAHPDVFNVLLQILEDGVLTDTHGRKVDFKNTIVIMTSNVGADFIEKQSKLGFKTENDEQSNYESMKDNVITQLRKTFRPEFLNRLDEIIVFHALNKEHIKQIADLMLDDLRERLNEKEMEIEITEAAKDKLAEDGYDSEFGARPLRRTIQRQIENELSIKILDKEIGENSKIKIDVVDGEYTFHTTKKVDKTAVKAE
>NC_014654.1|WP_013406435.1|2138793_2139873_-|DNA-integrity-scanning-protein-DisA
MEEIDEKLLDILKILAPGTILRDGLENILRAQTGGLIIVSDKKEVLELVNDGFKIGASVTPARLYELAKMDGAIVLDQEAENILFANAQLIPDPTVGSSETGTRHKTAERVARQTGELVIAISQRRSIITIYKKDSKHILEDIRVVLVKANQAIQTLDKYRSVFDQALTNLSALEFEDLVTVSDVVTVIQRTEMVLKIQREIEKYISELGSEGRLIKMQLEELVSNVKEEGLLLIEDYISEELEEDLTHPEAVLESLTDWSSDEILTLNTISKALGYSGSVNAFDESVSPRGYRILKKIPRLPMPVIENLVDEFKDLQAIIRASADELDDVDGIGEVRAQAIKDGLRRLRDQVLLDRHI
>NC_014654.1|WP_013406434.1|2138175_2138676_-|CarD-family-transcriptional-regulator
MYKIGDKVVYPNHGAGTIVGIETKTILDEKKKYYIMKLPIGEMKVMIPVDKIDKIGIRDVISEEKANDVFKLLNGEKSKMSQNWNRRYRANQEKLKTGDIFEVAEVVRNLSIRDREKGLSTGEKKMLSNARKILISELVLAKDMDEEEIAEKMDDLFILDEEDLEA
>NC_014654.1|WP_013406433.1|2137056_2138142_-|TRAM-domain-containing-protein
MLKKIMRYIFAIFGGIIAYHLVDIFGLATEYQFSWQNIGDFFLTTQFFAVLLGFLLGYFIIYYSLNQLLNFIMDFEVKVKDITWKKIVIAIIGLIIGLILGAIINFVFSIPNIPRIGMPLQILINITFTYMGFALAIHKEKEISSFIFQSNKENLDFTKADKTGSDKILDTSVIIDGRIFDICKTGFIEGNFIIPEFVLEELQHIADSSDDLKRNRGRRGLDILRQMQNDVKIKVKIIDADFEEISEVDSKLVRLAKNLDAKVLTNDYNLNKVAELQGVNVLNINELANAVKPVVLPGEQMDVKVIKEGKENGQGVAYLDDGTMIVIEDGVKYIGDDISVLVTSILQTAAGRMIFARPKTN
>NC_014654.1|WP_013406432.1|2136350_2137040_-|2-C-methyl-D-erythritol-4-phosphate-cytidylyltransferase
MNKVGVVIAAAGQGKRMGHNINKQFLPLLGKPILYYTIQSFADWGKAAEIVIVLNSKEIDYFKNKIQPLFSYSAQKTLSLVSGGNSRKESVYNGITSLSDNINYVLIHDGARPLIEKSLIESTYQAVKEHKAVSCGVKVKDTIKLVEDSISKQTLNRDKLRAIQTPQAFDLDLIKKAHHEYQKETALDDASLVELLGKNVYIVDGDYNNLKITTAEDLKPAEVILKERK
>NC_014654.1|WP_013406431.1|2135816_2136350_-|2-C-methyl-D-erythritol-2,4-cyclodiphosphate-synthase
MLKVGFGYDSHRFIKGRKLILGGVEILSEFGLKGHSDADLLIHALIDALLGALGSGDIGTHFPDDVPEYKDISSSKLLKKIVLEVNKEGFLINNCDLQVVAEKPKLQSYREQIVNSLADDLEITKDKINFKATTNEKMGFVGREEGMAAFAVVSIIEKRLWNFYNSIEGGEQTDDVS
>NC_014654.1|WP_013406430.1|2135038_2135830_-|CBS-domain-containing-protein
MMLVKDVMTANPITINPDATIMEAEKILSINKIGRLLVVENGELIGMLTDGDIISEKDLQAPVEDFMSEDLIKINEKKTVQDAAKKISDNHIGGLPVFNDKQELVGIVTSEDIVYGYLKDEEAEMEMEKKTITPESSAIYLSMTRSRDYEEYWLKKIQGYGYRGAITQTGASAEKLPIKLRESTTVAAIARGVINENSREKMAISNAVKDAYSQLALVNPGLGGGFKIAVVRGEGHVSVAIFGKFGHALVDGPEHLTVGTSVI
>NC_014654.1|WP_013406440.1|2152041_2152443_-|YjbQ-family-protein
MLKELSIESKDRVEFIDITYKIKKIVENSGVESGILQIHIPHTTAAVTINENADPSVKSDIKKELNKIVPFEDNYSHLEGNSAAHIKSSLIGVDQNLIIYNQQLKLGKWQGIYFCEFDGPRRRKIIVTILKNS
>NC_014654.1|WP_013406441.1|2152527_2154003_-|lysine--tRNA-ligase
MSENILEDMNELMLQRREKLAELREEKAFAEKYETTHHAAEIEKNYEELEDKEVKLAGRLMAIRTHGKASFADLMDMTSKVQLYIKQNNVGEDRYEFFQNLDLGDIIGITGTVFKTRRGEVSINVSSFELLTKALRPLPEKFHGLKDKDIRYRQRYLDLIVNPDVKETFVIRSKIIREMRNFLEEKGFLEVETPMMHPIAGGATARPFVTHHNTLDMDLYLRIAPELYLKRLIVGGFEKVFEINRNFRNEGMSYKHNPEFTTLELYQAQADYHDMMELTENLIYSLSKKVLDKTVVEYEGTELDLTTPWRRITMVEAVKEYAGVDFTEIDSAAEAYELANSIGIKPEEGLSYGEVLNEIFEERVEEKLIQPTFVMDYPIEVSPLAKKIADDPRFTYRFEGFIYGREIANAFSELNDPEEQKSRFEKQVEMREAGDEEAQMMDFDFIRALEYGMPPTGGLGIGIDRLIMLLTDSSSIRDVILFPTMRPESTN
>NC_014654.1|WP_013406442.1|2154099_2154582_-|transcription-elongation-factor-GreA
MAEQLMLTEEGFDKLENELDYLQNEKRREVAKRIKVAREFGDISENSEYDDAKNEQAFVEGRIKEIKNMLNNAHVVKDEDVTDTKVNLGTTVMLYNLDNDTKISYTLVGSAEADPLNHKISNESPIGKAILGHVIGDQVTVETPSGEAHYEILSIKKSKH
>NC_014654.1|WP_041596047.1|2154741_2155719_-|tRNA-dihydrouridine-synthase-DusB
MKISDISIEPSVFLAPMAGVSDYPYRQIVREMGVKLLYTEMVSAKGYEYGNNRTKELVEFEKKEDGKIAVQIFGEEADFMAAAAKNIANDYDIDIIDINMGCPARKIVSNGAGSALMKNLELAENIIGRVVEAVSIPVTVKMRSGWDEDNINAVELAKTAEKMGAAGLAVHGRTRKQFYKGKADWQIIKDVVDAVEIPVIANGDIFSAEDAAKAFDFINCSGIMIGRAAQGNPWIFKEVIEYLKNGRKIKGPSNQQKLEIAVKHINLAVDFYGEKQAIPLMRKHIAWYLKGMPYASKVKSKVNKIFEKDKLVSLLNDYKKEFDFS
>NC_014654.1|WP_013406444.1|2155726_2156500_-|type-III-pantothenate-kinase
MILTMDIGNTNTVLGLYEADELITHWRISTNRSKTPDEYGILFRNLFESENIKSGSVNSIIISSVVPPILRILKKTAYRYFGLNPLVIGPGVKTGMNIKTDNPKEVGADRIVNAVAASRLYSGPLIIVDFGTATTFCAVSAKGEYLGGAIAPGIGISTEALFNQSAKLPRIELIGPGNAISKNTIDGMKAGIVYGFVGQVEYLVDKFKVELSEDATVIATGGLVTLISAETDKINHVEPFLTLKGLKYIADINGMGS
>NC_014654.1|WP_013406445.1|2156513_2157455_-|nitronate-monooxygenase
MKLPELKIGNLKPELPIIQGGMAIRISMAELAAAVADEGGIGVIAGTVLGVQELKNEIKKAKEKTNGIIGVNIMFAAKNFKNLLHASVEAGVDVIISGAGFSRDMFSVGKESNTPVVPIVSSLKLARISEKLGAAAIVVEGGNAGGHLGTDEHSFDLIKKIVGKVNIPIIGAGDAVTPTDMEKMFEMGVDGIQMGTRFLASKEAAISEKFKELCVKASSSDVMKIMSSVGLKANAIKTEFANLIKEDKAPPPANCTDCLKHCKKNFCIRDALVAAKAGDMKNGVFFTGEGIGRIDEILSTQEIFQEIKDHFNI
>NC_014654.1|WP_013406446.1|2157585_2158557_-|BMP-family-ABC-transporter-substrate-binding-protein
MKKLIFLLFFFLVLTITGTISAENMKLAVITEVENTTAPSYNYASKLAMEELEIDFNINYDFIKTELLTDYLPKLSYLAESQADLIWAIGPSMQQSLKETAQMYSQKKFIIIDGIVELDNVLSINFAVEEGSFLAGVIAALKSESVVIAFIGERENNRSKKYEAGFFAGAKQVDQDIKLLSKYLCANNFKDTARETADQLYFNGADVIYYFTGSASDAIIASAEANDFYLIGVENKTVETVSDKILTNVIKNISYVLKKESNNFFDDAFQNGSKAYNLANYGLTIDQKIADNKLSDSIIDKLELYKNKIINGELEVPDNFNNY
>NC_014654.1|WP_013406447.1|2158584_2159439_-|biotin--[acetyl-CoA-carboxylase]-ligase
MVKQRSLNNLNKKNIYKNLAEIKGKNGLIDQIDLYIEKETDSTNEKAKRFIKKLSSTAIKELSEDRLFIFAADRQLEGKGRRGKKWLSSSEKSLSVSFLFKLPENYPEIPQVTAAAALAVKNTFEKFSLKTDIKWPNDILVNNKKICGILSELFFTEDKSAFVIIGCGVNLNNSCFNEEIKKSATSFYLEKSKKINKNIFLSNFIFEIEDYINKYFSGYRKEVISKWKKSLNIIGKKVKVRENNTLYNVIIKDVLDSGEILAELEDGSKKTFHSFNTSFEYSNL
>NC_014654.1|WP_160143068.1|2159511_2160141_-|folate-family-ECF-transporter-S-component
MSRPLSPKFPLSLVQKNYHPNRRGREVRILNFSTKRISQLSFLIALTIIFTRVFSIRIPVAGVEGVRVGFGALPIIFAGIAFGPLAGGIVGGLGDLLGYFINPLGAYMPHFTLTSFLTGFIPGLIVFYVLKRCRSLTVIFTAISIGQLITSIILVPYFINTLFGVPFAVLMPPRLISQLINIPLYTYFIMVVLNHNTVNIREIRAGTSC
>NC_014654.1|WP_013406449.1|2160273_2161944_-|formate--tetrahydrofolate-ligase
MKSDIQIAQASEMKEITEIAAQLGLSEDDLKLFGKYKAKVNLDVLKRLPEKEDSKLVLVTAITPTRAGEGKTTTTVGLGQALNRIGKNAVIALREPSLGPTMGIKGGAAGGGYSQVVPMEDINLHFTGDIHAIGVAHNLLSAVIDNHIKQGNELNIDPTRVTFKRALDMNDRALRNTVVGLGGTINGQPREDGFLITVASEVMAILCLANDLMELKEKLGKIVVAYTYEGKSITAHDLKVEGAMTALLKDAIKPNLVQTLENTPAFIHGGPFANIAHGCNSVMATKLAMKLADITITEAGFGADLGAEKFYNIKSRYADLNPDATVIVATIRALKMHGGVDIDNLKEENLSALKKGMANLEKHIENVAKFGVPAVVAINRFPDDTEAEIELIKKECHKLGVKTALSEVWSKGGEGGEELANKLLDILENEKSQFKFLYQTDSPIKEKIETIAREIYGAEGVEYSDKALNQIDKYREEGYSDLPICMAKTSSSISDNPALKGRPTGFKISINEINLSAGAGFLVVMTGPVLTMPGLPKRPSSEDIDIDADGKITGLF

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_014654_4	4.42\|1669615\|35\|NC_014654\|PILER-CR,CRISPRCasFinder,CRT	1669615-1669649	35	NC_019351	Lactococcus lactis subsp. cremoris plasmid pAF22, complete sequence	2809-2843	6	0.829
NC_014654_4	4.12\|1667434\|34\|NC_014654\|PILER-CR,CRISPRCasFinder,CRT	1667434-1667467	34	MN694758	Marine virus AFVG_250M853, complete genome	31663-31696	7	0.794
NC_014654_4	4.12\|1667434\|34\|NC_014654\|PILER-CR,CRISPRCasFinder,CRT	1667434-1667467	34	MN694077	Marine virus AFVG_250M852, complete genome	31668-31701	7	0.794
NC_014654_4	4.12\|1667434\|34\|NC_014654\|PILER-CR,CRISPRCasFinder,CRT	1667434-1667467	34	MN693989	Marine virus AFVG_250M851, complete genome	2148-2181	7	0.794
NC_014654_4	4.26\|1668452\|35\|NC_014654\|PILER-CR,CRISPRCasFinder,CRT	1668452-1668486	35	NZ_CP009639	Bacillus cereus 03BB108 plasmid pBFI_1, complete sequence	189203-189237	7	0.8
NC_014654_4	4.26\|1668452\|35\|NC_014654\|PILER-CR,CRISPRCasFinder,CRT	1668452-1668486	35	NZ_CP053963	Bacillus cereus strain FDAARGOS_802 plasmid unnamed3, complete sequence	230787-230821	7	0.8
NC_014654_4	4.12\|1667434\|34\|NC_014654\|PILER-CR,CRISPRCasFinder,CRT	1667434-1667467	34	NZ_CP007752	Campylobacter jejuni subsp. jejuni D42a plasmid pTet-D42a, complete sequence	31199-31232	8	0.765
NC_014654_4	4.12\|1667434\|34\|NC_014654\|PILER-CR,CRISPRCasFinder,CRT	1667434-1667467	34	NZ_CP017026	Campylobacter coli plasmid pCC14983A-1, complete sequence	103800-103833	8	0.765
NC_014654_4	4.22\|1668163\|35\|NC_014654\|PILER-CR,CRISPRCasFinder,CRT	1668163-1668197	35	NZ_CP013927	Alteromonas stellipolaris strain LMG 21861 plasmid pASTE61-200, complete sequence	24410-24444	8	0.771
NC_014654_4	4.12\|1667434\|34\|NC_014654\|PILER-CR,CRISPRCasFinder,CRT	1667434-1667467	34	AP013692	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C53A-MedDCM-OCT-S32-C67, * SEQUENCING IN PROGRESS *	13982-14015	9	0.735
NC_014654_4	4.12\|1667434\|34\|NC_014654\|PILER-CR,CRISPRCasFinder,CRT	1667434-1667467	34	AP013691	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C53A-MedDCM-OCT-S30-C57, * SEQUENCING IN PROGRESS *	24135-24168	9	0.735
NC_014654_4	4.12\|1667434\|34\|NC_014654\|PILER-CR,CRISPRCasFinder,CRT	1667434-1667467	34	AP013694	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C53A-MedDCM-OCT-S35-C68, * SEQUENCING IN PROGRESS *	24625-24658	9	0.735
NC_014654_4	4.12\|1667434\|34\|NC_014654\|PILER-CR,CRISPRCasFinder,CRT	1667434-1667467	34	AP013696	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C53A-MedDCM-OCT-S41-C66, * SEQUENCING IN PROGRESS *	26201-26234	9	0.735
NC_014654_4	4.12\|1667434\|34\|NC_014654\|PILER-CR,CRISPRCasFinder,CRT	1667434-1667467	34	AP013695	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C53A-MedDCM-OCT-S40-C60, * SEQUENCING IN PROGRESS *	6297-6330	9	0.735
NC_014654_4	4.12\|1667434\|34\|NC_014654\|PILER-CR,CRISPRCasFinder,CRT	1667434-1667467	34	AP013689	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C53A-MedDCM-OCT-S25-C57, * SEQUENCING IN PROGRESS *	24136-24169	9	0.735
NC_014654_4	4.12\|1667434\|34\|NC_014654\|PILER-CR,CRISPRCasFinder,CRT	1667434-1667467	34	AP013422	Uncultured Mediterranean phage uvMED DNA, complete genome, group G16, isolate: uvMED-CGR-C53A-MedDCM-OCT-S26-C61	19341-19374	9	0.735
NC_014654_4	4.12\|1667434\|34\|NC_014654\|PILER-CR,CRISPRCasFinder,CRT	1667434-1667467	34	AP013693	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C53A-MedDCM-OCT-S33-C59, * SEQUENCING IN PROGRESS *	8144-8177	9	0.735
NC_014654_4	4.12\|1667434\|34\|NC_014654\|PILER-CR,CRISPRCasFinder,CRT	1667434-1667467	34	AP013423	Uncultured Mediterranean phage uvMED DNA, complete genome, group G16, isolate: uvMED-CGR-C53A-MedDCM-OCT-S34-C54	13934-13967	9	0.735
NC_014654_4	4.12\|1667434\|34\|NC_014654\|PILER-CR,CRISPRCasFinder,CRT	1667434-1667467	34	AP013697	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C53A-MedDCM-OCT-S46-C69, * SEQUENCING IN PROGRESS *	7735-7768	9	0.735
NC_014654_4	4.26\|1668452\|35\|NC_014654\|PILER-CR,CRISPRCasFinder,CRT	1668452-1668486	35	NZ_LR027520	Thermus thermophilus isolate TTHNAR1 plasmid 4, complete sequence	36689-36723	9	0.743
NC_014654_4	4.42\|1669615\|35\|NC_014654\|PILER-CR,CRISPRCasFinder,CRT	1669615-1669649	35	AB012573	Vibrio phage Vf33 DNA, complete genome	4882-4916	9	0.743
NC_014654_4	4.42\|1669615\|35\|NC_014654\|PILER-CR,CRISPRCasFinder,CRT	1669615-1669649	35	NC_005948	Vibrio phage Vf33, complete genome	4882-4916	9	0.743
NC_014654_4	4.42\|1669615\|35\|NC_014654\|PILER-CR,CRISPRCasFinder,CRT	1669615-1669649	35	NC_005949	Vibrio phage Vf12 DNA, complete genome	4882-4916	9	0.743
NC_014654_4	4.42\|1669615\|35\|NC_014654\|PILER-CR,CRISPRCasFinder,CRT	1669615-1669649	35	NZ_CP019922	Borreliella burgdorferi strain PAbe plasmid p_lp17, complete sequence	6566-6600	9	0.743
NC_014654_4	4.42\|1669615\|35\|NC_014654\|PILER-CR,CRISPRCasFinder,CRT	1669615-1669649	35	NZ_CP019851	Borreliella burgdorferi plasmid lp17, complete sequence	6586-6620	9	0.743
NC_014654_4	4.42\|1669615\|35\|NC_014654\|PILER-CR,CRISPRCasFinder,CRT	1669615-1669649	35	NZ_CP019761	Borreliella burgdorferi strain B31_NRZ isolate B31 plasmid p_lp17, complete sequence	6587-6621	9	0.743
NC_014654_4	4.42\|1669615\|35\|NC_014654\|PILER-CR,CRISPRCasFinder,CRT	1669615-1669649	35	NC_004988	Borrelia burgdorferi ATCC 35210 plasmid lp16.9, complete sequence	10231-10265	9	0.743
NC_014654_4	4.42\|1669615\|35\|NC_014654\|PILER-CR,CRISPRCasFinder,CRT	1669615-1669649	35	NC_001849	Borreliella burgdorferi B31 plasmid lp17, complete sequence	10201-10235	9	0.743
NC_014654_4	4.42\|1669615\|35\|NC_014654\|PILER-CR,CRISPRCasFinder,CRT	1669615-1669649	35	NZ_CP040345	Bacillus albus strain DLOU-Yingkou plasmid unnamed1, complete sequence	441412-441446	10	0.714

1. spacer 4.42|1669615|35|NC_014654|PILER-CR,CRISPRCasFinder,CRT matches to NC_019351 (Lactococcus lactis subsp. cremoris plasmid pAF22, complete sequence) position: , mismatch: 6, identity: 0.829

tttaataattcattttcaatttttctttttaactt	CRISPR spacer
ttaaaatcttcattttcaatttttttttctaactt	Protospacer
** **   ****************.***.******

2. spacer 4.12|1667434|34|NC_014654|PILER-CR,CRISPRCasFinder,CRT matches to MN694758 (Marine virus AFVG_250M853, complete genome) position: , mismatch: 7, identity: 0.794

atgatggacaattaaaaaaaacttttgaatcctt	CRISPR spacer
ctaaagaaaaattaaataaaacttttgaatactt	Protospacer
 *.* *.* ******* ************* ***

3. spacer 4.12|1667434|34|NC_014654|PILER-CR,CRISPRCasFinder,CRT matches to MN694077 (Marine virus AFVG_250M852, complete genome) position: , mismatch: 7, identity: 0.794

atgatggacaattaaaaaaaacttttgaatcctt	CRISPR spacer
ctaaagaaaaattaaataaaacttttgaatactt	Protospacer
 *.* *.* ******* ************* ***

4. spacer 4.12|1667434|34|NC_014654|PILER-CR,CRISPRCasFinder,CRT matches to MN693989 (Marine virus AFVG_250M851, complete genome) position: , mismatch: 7, identity: 0.794

atgatggacaattaaaaaaaacttttgaatcctt	CRISPR spacer
ctaaagaaaaattaaataaaacttttgaatactt	Protospacer
 *.* *.* ******* ************* ***

5. spacer 4.26|1668452|35|NC_014654|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP009639 (Bacillus cereus 03BB108 plasmid pBFI_1, complete sequence) position: , mismatch: 7, identity: 0.8

tactaaccactcatcgccgccattaacctgattga	CRISPR spacer
actcaaccattcatcgccgccattaatctgattta	Protospacer
  ..*****.****************.****** *

6. spacer 4.26|1668452|35|NC_014654|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP053963 (Bacillus cereus strain FDAARGOS_802 plasmid unnamed3, complete sequence) position: , mismatch: 7, identity: 0.8

tactaaccactcatcgccgccattaacctgattga	CRISPR spacer
actcaaccattcatcgccgccattaatctgattta	Protospacer
  ..*****.****************.****** *

7. spacer 4.12|1667434|34|NC_014654|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP007752 (Campylobacter jejuni subsp. jejuni D42a plasmid pTet-D42a, complete sequence) position: , mismatch: 8, identity: 0.765

atgatggacaattaaaaaaaacttttgaatcctt	CRISPR spacer
atttttgacacataaaaaaaacttttgaattcgc	Protospacer
**  * ****  ******************.* .

8. spacer 4.12|1667434|34|NC_014654|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP017026 (Campylobacter coli plasmid pCC14983A-1, complete sequence) position: , mismatch: 8, identity: 0.765

atgatggacaattaaaaaaaacttttgaatcctt	CRISPR spacer
atttttgacacataaaaaaaacttttgaattcgc	Protospacer
**  * ****  ******************.* .

9. spacer 4.22|1668163|35|NC_014654|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013927 (Alteromonas stellipolaris strain LMG 21861 plasmid pASTE61-200, complete sequence) position: , mismatch: 8, identity: 0.771

ctacttgaccttttttcataacttaaccacctcct	CRISPR spacer
ctacttgacttgttttcataacttaaaacgctatt	Protospacer
*********.* **************    ** .*

10. spacer 4.12|1667434|34|NC_014654|PILER-CR,CRISPRCasFinder,CRT matches to AP013692 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C53A-MedDCM-OCT-S32-C67, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 9, identity: 0.735

atgat-ggacaattaaaaaaaacttttgaatcctt	CRISPR spacer
-tactaagacaattaaaaacaacttttcaatcagg	Protospacer
 *. * .************ ******* ****

11. spacer 4.12|1667434|34|NC_014654|PILER-CR,CRISPRCasFinder,CRT matches to AP013691 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C53A-MedDCM-OCT-S30-C57, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 9, identity: 0.735

atgat-ggacaattaaaaaaaacttttgaatcctt	CRISPR spacer
-tactaagacaattaaaaacaacttttcaatcagg	Protospacer
 *. * .************ ******* ****

12. spacer 4.12|1667434|34|NC_014654|PILER-CR,CRISPRCasFinder,CRT matches to AP013694 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C53A-MedDCM-OCT-S35-C68, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 9, identity: 0.735

atgat-ggacaattaaaaaaaacttttgaatcctt	CRISPR spacer
-tactaagacaattaaaaacaacttttcaatcagg	Protospacer
 *. * .************ ******* ****

13. spacer 4.12|1667434|34|NC_014654|PILER-CR,CRISPRCasFinder,CRT matches to AP013696 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C53A-MedDCM-OCT-S41-C66, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 9, identity: 0.735

atgat-ggacaattaaaaaaaacttttgaatcctt	CRISPR spacer
-tactaagacaattaaaaacaacttttcaatcagg	Protospacer
 *. * .************ ******* ****

14. spacer 4.12|1667434|34|NC_014654|PILER-CR,CRISPRCasFinder,CRT matches to AP013695 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C53A-MedDCM-OCT-S40-C60, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 9, identity: 0.735

atgat-ggacaattaaaaaaaacttttgaatcctt	CRISPR spacer
-tactaagacaattaaaaacaacttttcaatcagg	Protospacer
 *. * .************ ******* ****

15. spacer 4.12|1667434|34|NC_014654|PILER-CR,CRISPRCasFinder,CRT matches to AP013689 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C53A-MedDCM-OCT-S25-C57, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 9, identity: 0.735

atgat-ggacaattaaaaaaaacttttgaatcctt	CRISPR spacer
-tactaagacaattaaaaacaacttttcaatcagg	Protospacer
 *. * .************ ******* ****

16. spacer 4.12|1667434|34|NC_014654|PILER-CR,CRISPRCasFinder,CRT matches to AP013422 (Uncultured Mediterranean phage uvMED DNA, complete genome, group G16, isolate: uvMED-CGR-C53A-MedDCM-OCT-S26-C61) position: , mismatch: 9, identity: 0.735

atgat-ggacaattaaaaaaaacttttgaatcctt	CRISPR spacer
-tactaagacaattaaaaacaacttttcaatcagg	Protospacer
 *. * .************ ******* ****

17. spacer 4.12|1667434|34|NC_014654|PILER-CR,CRISPRCasFinder,CRT matches to AP013693 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C53A-MedDCM-OCT-S33-C59, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 9, identity: 0.735

atgat-ggacaattaaaaaaaacttttgaatcctt	CRISPR spacer
-tactaagacaattaaaaacaacttttcaatcagg	Protospacer
 *. * .************ ******* ****

18. spacer 4.12|1667434|34|NC_014654|PILER-CR,CRISPRCasFinder,CRT matches to AP013423 (Uncultured Mediterranean phage uvMED DNA, complete genome, group G16, isolate: uvMED-CGR-C53A-MedDCM-OCT-S34-C54) position: , mismatch: 9, identity: 0.735

atgat-ggacaattaaaaaaaacttttgaatcctt	CRISPR spacer
-tactaagacaattaaaaacaacttttcaatcagg	Protospacer
 *. * .************ ******* ****

19. spacer 4.12|1667434|34|NC_014654|PILER-CR,CRISPRCasFinder,CRT matches to AP013697 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C53A-MedDCM-OCT-S46-C69, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 9, identity: 0.735

atgat-ggacaattaaaaaaaacttttgaatcctt	CRISPR spacer
-tactaagacaattaaaaacaacttttcaatcagg	Protospacer
 *. * .************ ******* ****

20. spacer 4.26|1668452|35|NC_014654|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LR027520 (Thermus thermophilus isolate TTHNAR1 plasmid 4, complete sequence) position: , mismatch: 9, identity: 0.743

tactaaccactcatcgccgccattaacctgattga	CRISPR spacer
cccttcctcctcatcgccgcctttaccctgattgc	Protospacer
. **  *. ************ *** ********

21. spacer 4.42|1669615|35|NC_014654|PILER-CR,CRISPRCasFinder,CRT matches to AB012573 (Vibrio phage Vf33 DNA, complete genome) position: , mismatch: 9, identity: 0.743

tttaataattcattttcaatttttctttttaactt	CRISPR spacer
cctaataattcattttcaattttacttatcgtttc	Protospacer
..********************* *** *.. .*.

22. spacer 4.42|1669615|35|NC_014654|PILER-CR,CRISPRCasFinder,CRT matches to NC_005948 (Vibrio phage Vf33, complete genome) position: , mismatch: 9, identity: 0.743

tttaataattcattttcaatttttctttttaactt	CRISPR spacer
cctaataattcattttcaattttacttatcgtttc	Protospacer
..********************* *** *.. .*.

23. spacer 4.42|1669615|35|NC_014654|PILER-CR,CRISPRCasFinder,CRT matches to NC_005949 (Vibrio phage Vf12 DNA, complete genome) position: , mismatch: 9, identity: 0.743

tttaataattcattttcaatttttctttttaactt	CRISPR spacer
cctaataattcattttcaattttacttatcgtttc	Protospacer
..********************* *** *.. .*.

24. spacer 4.42|1669615|35|NC_014654|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP019922 (Borreliella burgdorferi strain PAbe plasmid p_lp17, complete sequence) position: , mismatch: 9, identity: 0.743

tttaataattcattttcaatttttctttttaactt	CRISPR spacer
atcaataattaattttcaatttttatttaaaagaa	Protospacer
 *.******* ************* ***  **

25. spacer 4.42|1669615|35|NC_014654|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP019851 (Borreliella burgdorferi plasmid lp17, complete sequence) position: , mismatch: 9, identity: 0.743

tttaataattcattttcaatttttctttttaactt	CRISPR spacer
atcaataattaattttcaatttttatttaaaagaa	Protospacer
 *.******* ************* ***  **

26. spacer 4.42|1669615|35|NC_014654|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP019761 (Borreliella burgdorferi strain B31_NRZ isolate B31 plasmid p_lp17, complete sequence) position: , mismatch: 9, identity: 0.743

tttaataattcattttcaatttttctttttaactt	CRISPR spacer
atcaataattaattttcaatttttatttaaaagaa	Protospacer
 *.******* ************* ***  **

27. spacer 4.42|1669615|35|NC_014654|PILER-CR,CRISPRCasFinder,CRT matches to NC_004988 (Borrelia burgdorferi ATCC 35210 plasmid lp16.9, complete sequence) position: , mismatch: 9, identity: 0.743

tttaataattcattttcaatttttctttttaactt	CRISPR spacer
atcaataattaattttcaatttttatttaaaagaa	Protospacer
 *.******* ************* ***  **

28. spacer 4.42|1669615|35|NC_014654|PILER-CR,CRISPRCasFinder,CRT matches to NC_001849 (Borreliella burgdorferi B31 plasmid lp17, complete sequence) position: , mismatch: 9, identity: 0.743

tttaataattcattttcaatttttctttttaactt	CRISPR spacer
atcaataattaattttcaatttttatttaaaagaa	Protospacer
 *.******* ************* ***  **

29. spacer 4.42|1669615|35|NC_014654|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP040345 (Bacillus albus strain DLOU-Yingkou plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.714

tttaataattcattttcaatttttctttttaactt	CRISPR spacer
atagacaattcattttctattttactttttattgc	Protospacer
 * .*.*********** ***** ******* . .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

30813 : 68937

Bacillus_phage(40.0%)

transposase,integrase,tRNA

attL 24925:24941|attR 59969:59985

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
24925:24941	attL	NA	NA	NA	NA
WP_013404629.1\|30813_32082_+\|tRNA	serine--tRNA ligase	A0A1B1IVT2	uncultured_Mediterranean_phage	2.9e-95	48.6
WP_013404630.1\|32338_32989_+	bifunctional 2-keto-4-hydroxyglutarate aldolase/2-keto-3-deoxy-6-phosphogluconate aldolase	NA	NA	NA	NA
WP_013404631.1\|33021_34044_+	sugar kinase	NA	NA	NA	NA
WP_013404632.1\|34168_35128_+	sugar kinase	NA	NA	NA	NA
WP_041595848.1\|35302_37684_+	ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent	A7XXH5	Thermus_virus	4.3e-116	39.4
WP_013404634.1\|37762_38050_-	hypothetical protein	NA	NA	NA	NA
WP_013404635.1\|38470_39424_+	2-hydroxyacid dehydrogenase	M1I636	Acanthocystis_turfacea_Chlorella_virus	2.0e-32	33.3
WP_013404636.1\|39848_40085_-	hypothetical protein	NA	NA	NA	NA
WP_013404637.1\|40153_41296_-\|integrase	site-specific integrase	A0A1B0T6A8	Bacillus_phage	4.5e-63	40.5
WP_013404638.1\|41354_41606_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_013404639.1\|41782_44713_+	hypothetical protein	NA	NA	NA	NA
WP_160143031.1\|46182_46353_+	hypothetical protein	NA	NA	NA	NA
WP_013404640.1\|46526_47444_+	ParB N-terminal domain-containing protein	NA	NA	NA	NA
WP_013404641.1\|47570_48092_+	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_013404642.1\|48266_48812_+\|integrase	site-specific integrase	A0A1B0T6D2	Bacillus_phage	1.1e-40	49.7
WP_013404643.1\|48887_50690_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	1.0e-29	27.7
WP_013404644.1\|50936_52238_+	phosphoenolpyruvate mutase	NA	NA	NA	NA
WP_013404645.1\|52242_53376_+	phosphonopyruvate decarboxylase	NA	NA	NA	NA
WP_013404646.1\|53375_54101_+	NTP transferase domain-containing protein	NA	NA	NA	NA
WP_013404647.1\|54105_55239_+	phosphonoacetaldehyde reductase	NA	NA	NA	NA
WP_187323464.1\|55333_56272_-\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_041595728.1\|56259_56547_-\|transposase	transposase	NA	NA	NA	NA
WP_013404649.1\|56706_58026_+	CDP-glycerol--poly(glycerophosphate) glycerophosphotransferase	NA	NA	NA	NA
WP_013404650.1\|59913_61194_+	glycosyltransferase	NA	NA	NA	NA
59969:59985	attR	NA	NA	NA	NA
WP_041595729.1\|61439_61739_+\|transposase	transposase	NA	NA	NA	NA
WP_013404651.1\|62904_63777_+	hypothetical protein	NA	NA	NA	NA
WP_083789325.1\|64200_64569_+\|transposase	transposase	A0A1P8CWQ3	Bacillus_phage	8.6e-24	51.8
WP_095522090.1\|64691_65805_+\|transposase	IS3 family transposase	A0A2I7SC85	Paenibacillus_phage	5.2e-80	56.7
WP_013404654.1\|65861_66905_-\|transposase	IS30 family transposase	H7BUM7	unidentified_phage	1.6e-51	35.4
WP_095522091.1\|67766_68937_+\|transposase	IS3 family transposase	A0A0P0I4A4	Acinetobacter_phage	2.7e-63	44.5

DBSCAN-SWA_2

79028 : 124735

uncultured_virus(28.57%)

transposase,tRNA,integrase

attL 80049:80067|attR 118833:118851

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013404666.1\|79028_79694_-\|integrase	tyrosine-type recombinase/integrase	S5W9T9	Leptospira_phage	3.7e-09	26.7
80049:80067	attL	NA	NA	NA	NA
WP_013404667.1\|80164_81019_+	hypothetical protein	NA	NA	NA	NA
WP_013404668.1\|81278_81479_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_013404669.1\|81544_82003_+	hypothetical protein	NA	NA	NA	NA
WP_013404670.1\|82276_85405_+	DNA primase catalytic core domain	NA	NA	NA	NA
WP_013404671.1\|85452_85959_+	hypothetical protein	NA	NA	NA	NA
WP_041595734.1\|86359_86548_+	hypothetical protein	NA	NA	NA	NA
WP_013404673.1\|86582_86930_+	DUF1232 domain-containing protein	NA	NA	NA	NA
WP_013404674.1\|86994_87339_+	hypothetical protein	NA	NA	NA	NA
WP_013404675.1\|87355_87922_+	hypothetical protein	NA	NA	NA	NA
WP_013404676.1\|87949_88510_+	host-nuclease inhibitor Gam family protein	NA	NA	NA	NA
WP_013404677.1\|88568_89420_+	hypothetical protein	NA	NA	NA	NA
WP_013404678.1\|89420_90272_+	phage recombination protein Bet	NA	NA	NA	NA
WP_013404679.1\|90317_90482_+	hypothetical protein	NA	NA	NA	NA
WP_013404680.1\|90474_90924_+	JAB domain-containing protein	NA	NA	NA	NA
WP_049773784.1\|91515_91728_+	hypothetical protein	NA	NA	NA	NA
WP_049773786.1\|91935_92268_+	hypothetical protein	NA	NA	NA	NA
WP_013404681.1\|92400_93282_+	hypothetical protein	NA	NA	NA	NA
WP_160143032.1\|93559_93796_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_013404682.1\|94207_94900_+	hypothetical protein	NA	NA	NA	NA
WP_013404683.1\|95284_96478_+\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	3.4e-29	37.6
WP_013404684.1\|96623_97865_-	anaerobic sulfatase maturase	NA	NA	NA	NA
WP_013404685.1\|97889_99569_-	SulP family inorganic anion transporter	NA	NA	NA	NA
WP_013404686.1\|99730_101167_+\|transposase	ISNCY family transposase	NA	NA	NA	NA
WP_160143033.1\|101566_102145_-	ABC transporter permease subunit	NA	NA	NA	NA
WP_083789271.1\|102259_102655_+\|transposase	transposase	NA	NA	NA	NA
WP_013404687.1\|102830_104336_-	sulfatase-like hydrolase/transferase	A0A2P0VMN7	Tetraselmis_virus	1.7e-09	23.7
WP_013404688.1\|104474_106172_-	solute:sodium symporter family transporter	A0A219Y9P9	Aeromonas_phage	4.8e-45	30.3
WP_013404689.1\|106467_107640_-	ROK family protein	NA	NA	NA	NA
WP_013404690.1\|108015_109008_-	aldo/keto reductase	NA	NA	NA	NA
WP_049773793.1\|109189_109672_+	aldo/keto reductase	A0A1V0SDE7	Indivirus	5.4e-26	41.8
WP_083789326.1\|109823_111059_-	acetamidase/formamidase family protein	NA	NA	NA	NA
WP_013404692.1\|111348_111699_+	hypothetical protein	NA	NA	NA	NA
WP_013404693.1\|111788_112526_+	YaaA family protein	NA	NA	NA	NA
WP_013404694.1\|112624_114043_-	cardiolipin synthase	NA	NA	NA	NA
WP_013404695.1\|114189_115371_+\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	3.4e-29	37.6
WP_013404696.1\|115534_117253_-	methyl-accepting chemotaxis protein	NA	NA	NA	NA
WP_013404697.1\|117520_118687_+\|transposase	transposase	NA	NA	NA	NA
WP_013404698.1\|119033_119456_+	NusG domain II-containing protein	NA	NA	NA	NA
118833:118851	attR	NA	NA	NA	NA
WP_013404699.1\|119484_120174_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	NA	NA	NA	NA
WP_013404700.1\|120301_120982_+	hypothetical protein	NA	NA	NA	NA
WP_013404701.1\|121135_121459_+	J domain-containing protein	NA	NA	NA	NA
WP_013404704.1\|121810_122038_-	hypothetical protein	NA	NA	NA	NA
WP_013404705.1\|122340_123702_+	MATE family efflux transporter	NA	NA	NA	NA
WP_013404706.1\|123715_124171_+	cytidine/deoxycytidylate deaminase family protein	A7KUY9	Bacillus_phage	1.5e-25	42.1
WP_013404707.1\|124219_124735_+\|tRNA	tRNA (N6-threonylcarbamoyladenosine(37)-N6)-methyltransferase TrmO	NA	NA	NA	NA

DBSCAN-SWA_3

259297 : 298992

Bacillus_phage(33.33%)

transposase,integrase

attL 272973:272992|attR 287133:287152

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_083789279.1\|259297_260425_-\|transposase	IS3 family transposase	A0A2I7SC85	Paenibacillus_phage	3.5e-84	58.0
WP_013404813.1\|260493_265386_+	DNA phosphorothioation-dependent restriction protein DptH	NA	NA	NA	NA
WP_160143036.1\|265461_266061_+	hypothetical protein	NA	NA	NA	NA
WP_013404815.1\|266083_267514_+	type II site-specific deoxyribonuclease	NA	NA	NA	NA
WP_013404816.1\|267640_268861_-	DNA (cytosine-5-)-methyltransferase	Q6DMX0	Streptococcus_phage	5.5e-27	37.1
WP_013404817.1\|269335_269572_+	hypothetical protein	NA	NA	NA	NA
WP_013404818.1\|270010_271084_+	hypothetical protein	NA	NA	NA	NA
WP_013404819.1\|271070_271607_+	hypothetical protein	NA	NA	NA	NA
WP_013404820.1\|271686_271869_-	YvrJ family protein	NA	NA	NA	NA
WP_013404821.1\|272274_273327_+	DUF4935 domain-containing protein	NA	NA	NA	NA
272973:272992	attL	NA	NA	NA	NA
WP_013404822.1\|273432_274188_-	ATP-binding protein	U5N3V8	Enterobacteria_phage	4.6e-40	37.4
WP_041595744.1\|274202_275369_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	U5N3F9	Enterobacteria_phage	7.7e-10	26.8
WP_095522092.1\|275442_276709_+\|transposase	IS3-like element ISHahy4 family transposase	NA	NA	NA	NA
WP_049773804.1\|276742_277258_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_013404825.1\|277636_278638_+	DUF2971 domain-containing protein	NA	NA	NA	NA
WP_013404826.1\|278682_279396_+	DUF4238 domain-containing protein	NA	NA	NA	NA
WP_083789280.1\|280948_281521_+	SEC-C domain-containing protein	NA	NA	NA	NA
WP_013404828.1\|282039_284793_+	diguanylate cyclase	G3MA91	Bacillus_virus	1.2e-21	40.1
WP_013404829.1\|285022_286147_+	glycerol dehydrogenase	NA	NA	NA	NA
WP_013404830.1\|286211_286394_+	hypothetical protein	NA	NA	NA	NA
WP_160143037.1\|288086_288305_+\|transposase	IS200/IS605 family transposase	A0A142F193	Bacillus_phage	1.8e-13	50.0
287133:287152	attR	NA	NA	NA	NA
WP_013404831.1\|288626_289316_+	deoxyribose-phosphate aldolase	NA	NA	NA	NA
WP_013404832.1\|289346_290885_+	FGGY-family carbohydrate kinase	NA	NA	NA	NA
WP_013404833.1\|291042_292590_+	alpha/beta fold hydrolase	NA	NA	NA	NA
WP_013404834.1\|292800_293571_+	sulfite exporter TauE/SafE family protein	NA	NA	NA	NA
WP_041595746.1\|293695_295522_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	1.9e-63	32.6
WP_160143084.1\|295542_297339_+	ATP-binding cassette domain-containing protein	W8CYL7	Bacillus_phage	2.2e-56	32.4
WP_160143085.1\|297393_297672_+	metalloregulator ArsR/SmtB family transcription factor	NA	NA	NA	NA
WP_013404838.1\|297921_298992_+\|transposase	IS30 family transposase	H7BUM7	unidentified_phage	1.7e-59	41.1

DBSCAN-SWA_4

396380 : 408816

Streptococcus_phage(50.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013404917.1\|396380_398189_+	DNA polymerase III subunit gamma/tau	A0A1U9WR94	Streptococcus_virus	3.0e-53	41.7
WP_013404918.1\|398190_398499_+	YbaB/EbfC family nucleoid-associated protein	NA	NA	NA	NA
WP_013404919.1\|398498_399098_+	recombination protein RecR	NA	NA	NA	NA
WP_013404920.1\|399398_400865_+	IMP dehydrogenase	A0A1V0SHK8	Klosneuvirus	1.8e-101	43.2
WP_013404921.1\|400978_401929_+	thioredoxin-disulfide reductase	A0A2I2L5E1	Orpheovirus	1.7e-68	46.1
WP_013404922.1\|402081_402708_+	dTMP kinase	M1PSC7	Streptococcus_phage	1.5e-39	42.8
WP_013404923.1\|402707_403067_+	cyclic-di-AMP receptor	NA	NA	NA	NA
WP_013404924.1\|403079_404069_+	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	7.7e-19	33.2
WP_013404925.1\|404093_404900_+	stage 0 sporulation family protein	NA	NA	NA	NA
WP_041595749.1\|404914_405235_+	DUF972 family protein	M1PFV3	Streptococcus_phage	1.2e-05	30.3
WP_013404927.1\|405239_405965_+\|tRNA	tRNA1(Val) (adenine(37)-N6)-methyltransferase	NA	NA	NA	NA
WP_013404928.1\|405965_406826_+	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	6.0e-52	42.7
WP_013404929.1\|406857_408816_+\|tRNA	methionine--tRNA ligase	A0A1V0SHR2	Klosneuvirus	4.3e-98	37.9

DBSCAN-SWA_5

644108 : 690684

Paenibacillus_phage(23.08%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_095522093.1\|644108_645235_-\|transposase	IS3-like element ISHahy2 family transposase	A0A2I7SC85	Paenibacillus_phage	1.7e-83	56.2
WP_083789293.1\|645298_645766_+	SUMF1/EgtB/PvdO family nonheme iron enzyme	NA	NA	NA	NA
WP_013405117.1\|646823_647534_-	PQQ-binding-like beta-propeller repeat protein	NA	NA	NA	NA
WP_013405118.1\|647534_648506_-	flagellin	NA	NA	NA	NA
WP_013405119.1\|649323_650739_+	group II intron reverse transcriptase/maturase	D4HTV9	Vibrio_phage	6.7e-16	24.2
WP_013405120.1\|650845_651031_+	hypothetical protein	NA	NA	NA	NA
WP_041595770.1\|651235_651427_+	hypothetical protein	NA	NA	NA	NA
WP_041595771.1\|651535_651835_+	hypothetical protein	NA	NA	NA	NA
WP_049773828.1\|651889_652333_+	host-nuclease inhibitor Gam family protein	A0A1B0XTM6	Freshwater_phage	7.4e-06	29.2
WP_013405121.1\|652673_655592_+	inverse autotransporter beta-barrel domain-containing protein	H9YQW5	environmental_Halophage	2.3e-15	40.7
WP_095522093.1\|655728_656854_+\|transposase	IS3-like element ISHahy2 family transposase	A0A2I7SC85	Paenibacillus_phage	1.7e-83	56.2
WP_013405122.1\|656886_657600_-	CpsD/CapB family tyrosine-protein kinase	NA	NA	NA	NA
WP_013405123.1\|657583_659047_-	LPS biosynthesis protein	NA	NA	NA	NA
WP_013405124.1\|659058_660177_-	SLBB domain-containing protein	NA	NA	NA	NA
WP_041595772.1\|660192_660969_-	histidinol-phosphatase	NA	NA	NA	NA
WP_013405126.1\|661095_661236_+	OmpA/MotB domain-containing protein	NA	NA	NA	NA
WP_013405127.1\|661393_662545_+	SEC-C domain-containing protein	V5LQX0	Emiliania_huxleyi_virus	7.3e-05	35.9
WP_013405128.1\|662674_663181_+	hypothetical protein	NA	NA	NA	NA
WP_013405129.1\|663376_665302_+	sigma 54-interacting transcriptional regulator	NA	NA	NA	NA
WP_013405130.1\|665562_666870_+	four-carbon acid sugar kinase family protein	NA	NA	NA	NA
WP_041595921.1\|666889_667885_+	4-hydroxythreonine-4-phosphate dehydrogenase PdxA	NA	NA	NA	NA
WP_013405132.1\|667901_668759_+	dihydrodipicolinate synthase family protein	NA	NA	NA	NA
WP_160143048.1\|668854_669946_+	iron-containing alcohol dehydrogenase	NA	NA	NA	NA
WP_013405134.1\|670025_671030_+	TRAP transporter substrate-binding protein	NA	NA	NA	NA
WP_013405135.1\|671148_671709_+	TRAP transporter small permease	NA	NA	NA	NA
WP_013405136.1\|671743_673030_+	TRAP transporter large permease	NA	NA	NA	NA
WP_013405137.1\|673078_674293_+	MFS transporter	NA	NA	NA	NA
WP_187323462.1\|674315_675077_+	glucose 1-dehydrogenase	A0A0N9R355	Chrysochromulina_ericina_virus	5.9e-19	29.1
WP_013405139.1\|675146_676220_+	exo-alpha-sialidase	NA	NA	NA	NA
WP_095522092.1\|676623_677890_+\|transposase	IS3-like element ISHahy4 family transposase	NA	NA	NA	NA
WP_041595733.1\|678341_679445_+	glycosyltransferase	NA	NA	NA	NA
WP_013404664.1\|679461_680079_+	sugar transferase	NA	NA	NA	NA
WP_013405141.1\|680099_681275_+	LegC family aminotransferase	E5ES46	Bathycoccus_sp._RCC1105_virus	9.7e-21	26.0
WP_095522093.1\|681867_682993_+\|transposase	IS3-like element ISHahy2 family transposase	A0A2I7SC85	Paenibacillus_phage	1.7e-83	56.2
WP_013405142.1\|683135_684173_+	glycosyltransferase family 4 protein	NA	NA	NA	NA
WP_013405143.1\|684266_685316_+\|transposase	IS30 family transposase	H7BUM7	unidentified_phage	2.7e-54	36.4
WP_013405144.1\|685500_686445_+	GDP-mannose 4,6-dehydratase	A0A2K9L4U8	Tupanvirus	9.5e-43	36.1
WP_013405145.1\|686487_687564_+	mannose-1-phosphate guanylyltransferase	A0A1V0SH58	Hokovirus	1.4e-37	32.0
WP_187323468.1\|688161_689991_+	DEAD/DEAH box helicase family protein	A0A097BY72	Enterococcus_phage	2.8e-14	22.7
WP_013405148.1\|690039_690384_+	hypothetical protein	NA	NA	NA	NA
WP_160143093.1\|690516_690684_-\|transposase	transposase	NA	NA	NA	NA

DBSCAN-SWA_6

1157357 : 1215945

Paenibacillus_phage(16.67%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_083789307.1\|1157357_1158485_-\|transposase	IS3-like element ISHahy2 family transposase	A0A2I7SC85	Paenibacillus_phage	2.3e-83	56.2
WP_013405558.1\|1158818_1159433_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_013405559.1\|1159521_1160568_+	AI-2E family transporter	NA	NA	NA	NA
WP_013405560.1\|1160939_1161275_+	hypothetical protein	NA	NA	NA	NA
WP_013404695.1\|1161503_1162685_+\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	3.4e-29	37.6
WP_013405561.1\|1162730_1164299_+\|transposase	IS21 family transposase	NA	NA	NA	NA
WP_013405162.1\|1164298_1165054_+	ATP-binding protein	A0A059NT77	Lactococcus_phage	1.5e-35	32.5
WP_013405562.1\|1165360_1166473_+	hypothetical protein	NA	NA	NA	NA
WP_013405563.1\|1166426_1166957_+	hypothetical protein	NA	NA	NA	NA
WP_013405564.1\|1167010_1167298_+	hypothetical protein	NA	NA	NA	NA
WP_013405565.1\|1167360_1167537_-	YvrJ family protein	NA	NA	NA	NA
WP_013405566.1\|1169730_1169961_+	hypothetical protein	NA	NA	NA	NA
WP_095522094.1\|1170066_1170405_+	MBL fold metallo-hydrolase	Q332C0	Clostridium_botulinum_C_phage	3.8e-18	51.1
WP_095522092.1\|1170462_1171729_+\|transposase	IS3-like element ISHahy4 family transposase	NA	NA	NA	NA
WP_160143053.1\|1171974_1172619_+	hypothetical protein	NA	NA	NA	NA
WP_013405568.1\|1172634_1172811_+	hypothetical protein	NA	NA	NA	NA
WP_013405569.1\|1172831_1175780_+	site-specific DNA-methyltransferase	A0A2K5B2C1	Erysipelothrix_phage	9.2e-68	40.6
WP_013405570.1\|1175795_1179170_+	DEAD/DEAH box helicase family protein	NA	NA	NA	NA
WP_013405571.1\|1179190_1182025_+	ATP-dependent helicase	A7KV33	Bacillus_phage	8.3e-34	24.4
WP_013405572.1\|1182134_1184174_+	hypothetical protein	NA	NA	NA	NA
WP_013404695.1\|1184296_1185478_-\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	3.4e-29	37.6
WP_013405573.1\|1185555_1186557_+	hypothetical protein	NA	NA	NA	NA
WP_013405574.1\|1187719_1188346_+	DUF2225 domain-containing protein	NA	NA	NA	NA
WP_013405575.1\|1188403_1188703_+	hypothetical protein	NA	NA	NA	NA
WP_013405576.1\|1189232_1191074_+	HAMP domain-containing protein	W8CYF6	Bacillus_phage	5.1e-16	27.5
WP_013405577.1\|1191066_1191465_+	response regulator	NA	NA	NA	NA
WP_013405578.1\|1191454_1192150_+	response regulator	Q6XM27	Feldmannia_irregularis_virus	5.2e-06	27.0
WP_013405579.1\|1192150_1192549_+	TrkA family potassium uptake protein	NA	NA	NA	NA
WP_013405580.1\|1192566_1193229_+	TrkA family potassium uptake protein	NA	NA	NA	NA
WP_013405581.1\|1193230_1194715_+	TrkH family potassium uptake protein	NA	NA	NA	NA
WP_013405582.1\|1195117_1195630_+	YeeE/YedE family protein	NA	NA	NA	NA
WP_013405583.1\|1195648_1196185_+	YeeE/YedE family protein	NA	NA	NA	NA
WP_013405584.1\|1196186_1197980_+	SLC13 family permease	NA	NA	NA	NA
WP_013405585.1\|1198014_1198596_-	hypothetical protein	NA	NA	NA	NA
WP_013405586.1\|1198898_1201544_+	diguanylate cyclase	NA	NA	NA	NA
WP_160143054.1\|1202751_1202928_+	hypothetical protein	NA	NA	NA	NA
WP_013405587.1\|1203176_1203362_+	hypothetical protein	NA	NA	NA	NA
WP_013405588.1\|1203649_1207051_+	diguanylate cyclase	G3MA91	Bacillus_virus	2.1e-15	33.5
WP_013405589.1\|1207099_1208548_+	AAA family ATPase	NA	NA	NA	NA
WP_013405590.1\|1208584_1210351_+	diguanylate cyclase	A0A2D0W9B6	Bordetella_phage	8.6e-05	35.1
WP_013405591.1\|1210522_1211833_+	glucose-1-phosphate adenylyltransferase	NA	NA	NA	NA
WP_013405592.1\|1211996_1214477_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_095522093.1\|1214819_1215945_+\|transposase	IS3-like element ISHahy2 family transposase	A0A2I7SC85	Paenibacillus_phage	1.7e-83	56.2

DBSCAN-SWA_7

1543257 : 1551676

uncultured_Mediterranean_phage(33.33%)

protease,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013405881.1\|1543257_1543518_-	stage V sporulation protein S	A0A1J0GVV0	Streptomyces_phage	3.3e-06	40.8
WP_013405882.1\|1543683_1544394_-	rRNA pseudouridine synthase	NA	NA	NA	NA
WP_013405883.1\|1544415_1545072_-	SMC-Scp complex subunit ScpB	A0A1B1IVT7	uncultured_Mediterranean_phage	9.3e-13	38.6
WP_013405884.1\|1545077_1545803_-	segregation/condensation protein A	A0A1B1IVW1	uncultured_Mediterranean_phage	1.1e-09	32.4
WP_013405885.1\|1545818_1546460_-\|protease	site-2 protease family protein	NA	NA	NA	NA
WP_013405886.1\|1546486_1548133_-\|tRNA	CCA tRNA nucleotidyltransferase	A0A0S2MWE1	Cellulophaga_phage	5.9e-16	33.6
WP_013405887.1\|1548193_1549522_-	nicotinate phosphoribosyltransferase	NA	NA	NA	NA
WP_013405888.1\|1549543_1550848_-	pyrimidine-nucleoside phosphorylase	A0A0H3UZD4	Geobacillus_virus	2.5e-126	57.6
WP_013405889.1\|1550863_1551676_-	purine-nucleoside phosphorylase	Q5YBA4	Grouper_iridovirus	4.0e-58	42.6

DBSCAN-SWA_8

1836307 : 1846177

uncultured_Mediterranean_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013406142.1\|1836307_1838455_-	bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase	A0A2I2L310	Orpheovirus	6.1e-13	36.8
WP_013406143.1\|1838496_1839009_-	adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	4.2e-29	44.5
WP_013406144.1\|1838998_1841416_-	single-stranded-DNA-specific exonuclease RecJ	A7KV88	Bacillus_phage	8.0e-70	31.6
WP_013406145.1\|1841440_1843105_-	AarF/ABC1/UbiB kinase family protein	E5ERK4	Ostreococcus_lucimarinus_virus	2.4e-41	29.7
WP_013406146.1\|1843198_1844059_-	protein translocase subunit SecF	A0A1B1IVP7	uncultured_Mediterranean_phage	3.3e-42	41.6
WP_013406147.1\|1844064_1845273_-	protein translocase subunit SecD	NA	NA	NA	NA
WP_013406148.1\|1845302_1845848_-	signal peptidase I	NA	NA	NA	NA
WP_013406149.1\|1845880_1846177_-	preprotein translocase subunit YajC	A0A1B1IVR5	uncultured_Mediterranean_phage	1.8e-11	48.1

DBSCAN-SWA_9

1946916 : 1956664

Planktothrix_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013406243.1\|1946916_1947954_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	4.7e-19	31.4
WP_160143118.1\|1948038_1948611_-	transglycosylase SLT domain-containing protein	NA	NA	NA	NA
WP_013406245.1\|1948643_1949621_-	dephospho-CoA kinase	NA	NA	NA	NA
WP_013406246.1\|1949643_1950474_-	DNA-formamidopyrimidine glycosylase	G3MA33	Bacillus_virus	3.5e-33	33.1
WP_013406247.1\|1950466_1953109_-	DNA polymerase I	A0A0C5K9B9	Enterococcus_phage	1.5e-48	28.6
WP_013406248.1\|1953144_1954524_-	HAMP domain-containing protein	A0A1V0SGX0	Hokovirus	1.7e-19	30.1
WP_013406249.1\|1954516_1955206_-	response regulator transcription factor	W8CYM9	Bacillus_phage	5.0e-41	37.6
WP_013406250.1\|1955521_1956664_-	trypsin-like peptidase domain-containing protein	A0A1B1IT49	uncultured_Mediterranean_phage	1.6e-20	28.6

DBSCAN-SWA_10

1983252 : 2006179

unidentified_phage(22.22%)

transposase,holin,integrase

attL 1983054:1983069|attR 1996150:1996165

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1983054:1983069	attL	NA	NA	NA	NA
WP_013404750.1\|1983252_1984614_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	A0A1X9I6C6	Streptococcus_phage	8.7e-13	32.9
WP_013406273.1\|1984945_1985149_-	cold-shock protein	A0A1W6JNX5	Morganella_phage	2.2e-13	61.9
WP_013406274.1\|1985475_1986741_+	NADH-ubiquinone oxidoreductase	NA	NA	NA	NA
WP_013406275.1\|1986805_1987750_-	glycine/betaine ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_013406276.1\|1987766_1988387_-	ABC transporter permease	NA	NA	NA	NA
WP_013406277.1\|1988390_1989053_-	ABC transporter permease	NA	NA	NA	NA
WP_013406278.1\|1989070_1990180_-\|holin	betaine/proline/choline family ABC transporter ATP-binding protein	F2Y1V5	Organic_Lake_phycodnavirus	1.4e-13	27.9
WP_013406279.1\|1990452_1990932_-	phosphatidylglycerophosphatase A	G3MBC5	Bacillus_virus	9.1e-42	58.3
WP_013406280.1\|1991027_1991981_-	ADP-ribosylglycohydrolase family protein	A0A1S6UB21	Serratia_phage	1.2e-40	34.9
WP_013406281.1\|1992006_1992330_-	hypothetical protein	NA	NA	NA	NA
WP_013406282.1\|1992354_1992933_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_013406283.1\|1993274_1994495_+	diaminopropionate ammonia-lyase	NA	NA	NA	NA
WP_083789336.1\|1994969_1995245_-	HD domain-containing protein	NA	NA	NA	NA
WP_095522093.1\|1995308_1996434_+\|transposase	IS3-like element ISHahy2 family transposase	A0A2I7SC85	Paenibacillus_phage	1.7e-83	56.2
1996150:1996165	attR	NA	NA	NA	NA
WP_013406284.1\|1996505_1998128_-	diguanylate cyclase	NA	NA	NA	NA
WP_013405143.1\|1998334_1999384_-\|transposase	IS30 family transposase	H7BUM7	unidentified_phage	2.7e-54	36.4
WP_013406285.1\|1999615_1999807_+	hypothetical protein	NA	NA	NA	NA
WP_013406286.1\|1999877_2000135_-	hypothetical protein	NA	NA	NA	NA
WP_013404838.1\|2000517_2001588_-\|transposase	IS30 family transposase	H7BUM7	unidentified_phage	1.7e-59	41.1
WP_013406287.1\|2001711_2002851_-	hypothetical protein	NA	NA	NA	NA
WP_013406288.1\|2002985_2004410_-	GntR family transcriptional regulator	NA	NA	NA	NA
WP_013406289.1\|2004569_2004815_-	hypothetical protein	NA	NA	NA	NA
WP_013404695.1\|2004997_2006179_+\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	3.4e-29	37.6

DBSCAN-SWA_11

2466319 : 2473810

Synechococcus_phage(42.86%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013406719.1\|2466319_2467897_-	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	Q58MG4	Prochlorococcus_phage	1.9e-64	44.8
WP_013406720.1\|2467898_2468513_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	4.3e-28	42.5
WP_013406721.1\|2468517_2469582_-	phosphoribosylformylglycinamidine cyclo-ligase	R9TMC7	Synechococcus_phage	3.1e-66	45.0
WP_013406722.1\|2469581_2471093_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	6.4e-57	35.8
WP_013406723.1\|2471149_2471869_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	G8EYA2	Synechococcus_phage	2.1e-42	39.7
WP_013406724.1\|2471898_2473290_-	adenylosuccinate lyase	A0A1B1ISB0	uncultured_Mediterranean_phage	9.1e-26	27.3
WP_013406725.1\|2473279_2473810_-	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	1.2e-26	50.7

DBSCAN-SWA_12

2541704 : 2568775

Clostridioides_phage(28.57%)

transposase,holin,integrase

attL 2544248:2544305|attR 2554994:2555051

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013406786.1\|2541704_2543024_-\|transposase	ISNCY family transposase	NA	NA	NA	NA
WP_013406787.1\|2543211_2543649_+	DNA starvation/stationary phase protection protein	NA	NA	NA	NA
WP_160143076.1\|2543750_2543924_-	hypothetical protein	NA	NA	NA	NA
2544248:2544305	attL	NA	NA	NA	NA
WP_041595842.1\|2544508_2545225_-	hypothetical protein	NA	NA	NA	NA
WP_013404838.1\|2545277_2546348_-\|transposase	IS30 family transposase	H7BUM7	unidentified_phage	1.7e-59	41.1
WP_049773906.1\|2546425_2549116_-	N-6 DNA methylase	A0A2R2ZGH5	Clostridioides_phage	2.0e-133	35.1
WP_013406789.1\|2549244_2549691_-	hypothetical protein	NA	NA	NA	NA
WP_013406790.1\|2549702_2550503_-	endonuclease/exonuclease/phosphatase family protein	NA	NA	NA	NA
WP_095522092.1\|2550618_2551885_+\|transposase	IS3-like element ISHahy4 family transposase	NA	NA	NA	NA
WP_013406791.1\|2551918_2552191_-	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	S5MA41	Brevibacillus_phage	3.0e-18	56.3
WP_095522093.1\|2552595_2553721_+\|transposase	IS3-like element ISHahy2 family transposase	A0A2I7SC85	Paenibacillus_phage	1.7e-83	56.2
WP_160143077.1\|2553627_2554596_-	hypothetical protein	NA	NA	NA	NA
WP_083789322.1\|2554654_2554903_+\|integrase	tyrosine-type recombinase/integrase	A0A2R2ZGM9	Clostridioides_phage	3.5e-13	43.6
WP_013406792.1\|2555163_2555658_-	intracellular proteinase inhibitor	NA	NA	NA	NA
2554994:2555051	attR	NA	NA	NA	NA
WP_013406793.1\|2555714_2556131_-	YjbQ family protein	NA	NA	NA	NA
WP_013406794.1\|2556155_2556581_-	MgtC/SapB family protein	G3MA03	Bacillus_virus	3.8e-23	45.9
WP_013406795.1\|2556599_2557106_-	GGDEF domain-containing protein	NA	NA	NA	NA
WP_013406796.1\|2557230_2557890_-	hypothetical protein	NA	NA	NA	NA
WP_013406797.1\|2558014_2561551_-	pyruvate:ferredoxin (flavodoxin) oxidoreductase	NA	NA	NA	NA
WP_013406798.1\|2561710_2562331_-	methyltransferase domain-containing protein	NA	NA	NA	NA
WP_013406799.1\|2562499_2563609_+	hypothetical protein	NA	NA	NA	NA
WP_013406800.1\|2563633_2564119_+	hypothetical protein	NA	NA	NA	NA
WP_013406801.1\|2564162_2565329_-	nucleotide sugar dehydrogenase	M1HIV9	Acanthocystis_turfacea_Chlorella_virus	3.2e-109	50.5
WP_013406802.1\|2565485_2566136_-	hypothetical protein	NA	NA	NA	NA
WP_013406803.1\|2566365_2567646_+	glutamate--cysteine ligase	NA	NA	NA	NA
WP_160143134.1\|2567742_2568381_-	hypothetical protein	NA	NA	NA	NA
WP_013406805.1\|2568424_2568775_-\|holin	phage holin family protein	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_014654

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection