CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_016023	Bacillus coagulans 36D1, complete sequence	18 crisprs	cas14j,casR,RT,DinG,csa3,PrimPol,cas6,cas8b1,cas7b,cas5,cas3,cas4,cas1,cas2	3	16	5	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_016023_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016023_1

286877-287016

TypeV

Consensus_repeat	Method
TTCCCCGGATTGTCGTTTGCTGTGCCGGTTCC	CRISPRCasFinder

1 spacers

cas14j

The CRISPR arrays of NC_016023_1

>merge|NC_016023|1|286877-287016|CRISPRCasFinder
TTATCCGGATTGTCATTTGTTGTGCCATTCCCCGGATTGTCGTTTGCTGTGCCGGTTCCGGAGCCATTCCCCGGCGCGTTGCCAGCCCCATTTCCGGTACCGGAGCCGTTCCCCGGATTGTCGTTTGCTGTGCCGTTCCC

>NC_016023|1|1|286877-287016|CRISPRCasFinder
TTATCCGGATTGTCATTTGTTGTGCCATTCCC	CGGATTGTCGTTTGCTGTGCCGGTTCCGGAGCCATTCCCCGGCGCGTTGCCAGCCCCATTTCCGGTACCGGAGCCG
TTCCCCGGATTGTCGTTTGCTGTGCCGTTCCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_016023.1\|WP_014095679.1\|297380_297920_+\|chromate-transporter	unknown	unknown	gnl\|CDD\|224970
NC_016023.1\|WP_014095674.1\|294316_295435_-\|helix-turn-helix-domain-containing-protein	cas14j	-	gnl\|CDD\|223747
NC_016023.1\|WP_014095664.1\|281158_284266_+\|type-I-restriction-endonuclease-subunit-R	unknown	unknown	gnl\|CDD\|223683
NC_016023.1\|WP_014095661.1\|277704_278298_+\|restriction-endonuclease-subunit-S	unknown	unknown	gnl\|CDD\|341131
NC_016023.1\|WP_014095657.1\|271526_272945_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340924
NC_016023.1\|WP_035181994.1\|289468_289765_-\|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl\|CDD\|227179
NC_016023.1\|WP_014095663.1\|279835_281119_+\|restriction-endonuclease-subunit-S	unknown	unknown	gnl\|CDD\|341162
NC_016023.1\|WP_052301516.1\|293947_294322_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227308
NC_016023.1\|WP_014095658.1\|273603_274593_-\|lactate-dehydrogenase	unknown	unknown	gnl\|CDD\|240661
NC_016023.1\|WP_014095655.1\|268563_268839_-\|hypothetical-protein	unknown	unknown	unknown
NC_016023.1\|WP_014095670.1\|289997_291101_+\|5-methyltetrahydropteroyltriglutamate---homocysteine-S-methyltransferase	unknown	unknown	gnl\|CDD\|180601
NC_016023.1\|WP_014095678.1\|296784_297384_+\|chromate-transporter	unknown	unknown	gnl\|CDD\|224970
NC_016023.1\|WP_014095665.1\|284279_285002_+\|M48-family-metallopeptidase	unknown	unknown	gnl\|CDD\|307807
NC_016023.1\|WP_014095677.1\|296295_296772_+\|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
NC_016023.1\|WP_014095656.1\|269271_270195_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235853
NC_016023.1\|WP_014095662.1\|278297_279827_+\|type-I-restriction-modification-system-subunit-M	unknown	unknown	gnl\|CDD\|223363
NC_016023.1\|WP_014095672.1\|292735_293614_+\|PocR-ligand-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|378400
NC_016023.1\|WP_014095671.1\|291186_292410_-\|acetate-kinase	unknown	unknown	gnl\|CDD\|234680
NC_016023.1\|WP_014095675.1\|295522_295663_+\|hypothetical-protein	unknown	unknown	unknown
NC_016023.1\|WP_014095660.1\|275476_276790_-\|IS1380-like-element-ISBco1-family-transposase	unknown	unknown	gnl\|CDD\|379340

Protein	Function_ID	Function_description	E-value
NC_016023.1\|WP_014095679.1\|297380_297920_+\|chromate-transporter	gnl\|CDD\|224970	COG2059, ChrA, Chromate transport protein ChrA [Inorganic ion transport and metabolism].	6.71509e-41
NC_016023.1\|WP_014095674.1\|294316_295435_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	6.64028e-54
NC_016023.1\|WP_014095664.1\|281158_284266_+\|type-I-restriction-endonuclease-subunit-R	gnl\|CDD\|223683	COG0610, COG0610, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms].	1.65335e-141
NC_016023.1\|WP_014095661.1\|277704_278298_+\|restriction-endonuclease-subunit-S	gnl\|CDD\|341131	cd16961, RMtype1_S_TRD-CR_like, Type I restriction-modification system specificity (S) subunit Target Recognition Domain-ConseRved domain (TRD-CR) and similar domains. The restriction-modification (RM) system S subunit generally consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one heteromeric enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This superfamily represents a single TRD-CR unit; in addition to type I TRD-CR units, it includes RMtype1_S_TRD-CR_like domains of various putative Helicobacter type II restriction enzymes and methyltransferases, such as Hci611ORFHP and HfeORF12890P, as well as TRD-CR-like sequence-recognition domains of the M subunit of putative type I DNA methyltransferase such as M2.CinURNWORF2828P and M.Mae7806ORF3969P.	3.59528e-13
NC_016023.1\|WP_014095657.1\|271526_272945_-\|MFS-transporter	gnl\|CDD\|340924	cd17366, MFS_ProP, Proline/betaine transporter of the Major Facilitator Superfamily of transporters. This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	6.8387e-178
NC_016023.1\|WP_035181994.1\|289468_289765_-\|WXG100-family-type-VII-secretion-target	gnl\|CDD\|227179	COG4842, COG4842, Uncharacterized protein conserved in bacteria [Function unknown].	1.76308e-22
NC_016023.1\|WP_014095663.1\|279835_281119_+\|restriction-endonuclease-subunit-S	gnl\|CDD\|341162	cd17273, RMtype1_S_EcoJA69PI-TRD1-CR1_like, Type I restriction-modification system specificity (S) subunit Target Recognition Domain-ConseRved domain (TRD-CR), similar to S.EcoJA69PI TRD1-CR1, MjaXIP/S.MjaORF132P TRD2-CR2, and S.HspDL1ORF16625P TRD2-CR2. Escherichia coli UCD_JA69_pb S subunit (S.EcoJA69PI) recognizes 5'... CCANNNNNNNCTTC ... 3'. The recognition sequences of Methanococcus jannaschii MjaXIP/S.MjaORF132P TRD2-CR2 and Halobacterium species DL1 S subunit (S.HspDL1ORF16625P) are undetermined. The restriction-modification (RM) system S subunit consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. It also includes TRD-CR-like sequence-recognition domains of various putative type II restriction enzymes and methyltransferases and may also include type I DNA methyltransferases.	1.98e-91
NC_016023.1\|WP_052301516.1\|293947_294322_+\|hypothetical-protein	gnl\|CDD\|227308	COG4974, XerD, Site-specific recombinase XerD [DNA replication, recombination, and repair].	1.53703e-05
NC_016023.1\|WP_014095658.1\|273603_274593_-\|lactate-dehydrogenase	gnl\|CDD\|240661	cd12185, HGDH_LDH_like, Putative Lactate dehydrogenase and (R)-2-Hydroxyglutarate Dehydrogenase-like proteins, NAD-binding and catalytic domains. This group contains various putative dehydrogenases related to D-lactate dehydrogenase (LDH), (R)-2-hydroxyglutarate dehydrogenase (HGDH), and related enzymes, members of the 2-hydroxyacid dehydrogenases family. LDH catalyzes the interconversion of pyruvate and lactate, and HGDH catalyzes the NAD-dependent reduction of 2-oxoglutarate to (R)-2-hydroxyglutarate. Despite often low sequence identity within this 2-hydroxyacid dehydrogenase family, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain.	5.01999e-177
NC_016023.1\|WP_014095670.1\|289997_291101_+\|5-methyltetrahydropteroyltriglutamate---homocysteine-S-methyltransferase	gnl\|CDD\|180601	PRK06520, PRK06520, 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase.	0
NC_016023.1\|WP_014095678.1\|296784_297384_+\|chromate-transporter	gnl\|CDD\|224970	COG2059, ChrA, Chromate transport protein ChrA [Inorganic ion transport and metabolism].	3.96864e-46
NC_016023.1\|WP_014095665.1\|284279_285002_+\|M48-family-metallopeptidase	gnl\|CDD\|307807	pfam01863, DUF45, Protein of unknown function DUF45. This protein has no known function. Members are found in some archaebacteria, as well as Helicobacter pylori. The proteins are 190-240 amino acids long, with the C-terminus being the most conserved region, containing three conserved histidines. This motif is similar to that found in Zinc proteases, suggesting that this family may also be proteases.	8.8255e-64
NC_016023.1\|WP_014095677.1\|296295_296772_+\|Lrp/AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	5.43018e-39
NC_016023.1\|WP_014095656.1\|269271_270195_+\|SDR-family-oxidoreductase	gnl\|CDD\|235853	PRK06701, PRK06701, short chain dehydrogenase; Provisional.	6.05557e-173
NC_016023.1\|WP_014095662.1\|278297_279827_+\|type-I-restriction-modification-system-subunit-M	gnl\|CDD\|223363	COG0286, HsdM, Type I restriction-modification system methyltransferase subunit [Defense mechanisms].	1.18854e-136
NC_016023.1\|WP_014095672.1\|292735_293614_+\|PocR-ligand-binding-domain-containing-protein	gnl\|CDD\|378400	pfam10114, PocR, Sensory domain found in PocR. PocR, a ligand binding domain, has a novel variant of the PAS-like Fold. Evidence suggests that it binds small hydrocarbon derivatives such as 1,3-propanediol. In (Natural history of sensor domains in bacterial signaling systems by Aravind L, LM Iyer, Anantharaman V, from 'Sensory Mechanisms in Bacteria: Molecular Aspects of Signal Recognition.' Caister Academic Press. 2010) - see (http://de.scribd.com/doc/28576661/Bacterial-Signaling-Chapter).	1.00766e-47
NC_016023.1\|WP_014095671.1\|291186_292410_-\|acetate-kinase	gnl\|CDD\|234680	PRK00180, PRK00180, acetate kinase A/propionate kinase 2; Reviewed.	0
NC_016023.1\|WP_014095660.1\|275476_276790_-\|IS1380-like-element-ISBco1-family-transposase	gnl\|CDD\|379340	pfam13701, DDE_Tnp_1_4, Transposase DDE domain group 1. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	0

>NC_016023.1|WP_014095665.1|284279_285002_+|M48-family-metallopeptidase
MEKHQIEYANKVIDFVLKRKKVKNVNLNIKPDMTIEVTANDRVPLDFICDFVKTKGAWILKNVKTFKDVQPYRQSEREYVSGETFKYLGKQYRLRVMQEEEEKVKYFRGFIYLYVKDTENVNRKAKLIDEWYREKAQKTFHESLAKMFPLVQKYGVDKPNIDLRSMKARWGSALTEKNTILLNTDLIKAPKYCIDYVVLHELIHFKYNDHSDNFYKMLYSLMPDWEKRKAILDEEVVKDL
>NC_016023.1|WP_014095664.1|281158_284266_+|type-I-restriction-endonuclease-subunit-R
MQREKSYDERYISQVPAIEVLQKLGYQYLSPEEAERMRGNLHHVLLTTVLEEKLKELNSYEYQSQIYQFSESNIRQAIRDLDEPLTNGLVKTNEVIYETIMNGRSYTEFLPDGSKKSFTIQYIDWNNIENNVFHVVEEFEVERMDGRGTVRPDIVLFVNGIPFAVIECKKASISMNQGISQMIRNQGKDYAPQLFKFVQIVMSTNKNETKYATCNTPKKFWSVWKEEKAEWLQNWLDKTVEGRLPTMQDKNIISLFHPERLLELTQFFTLFDKDVKKVARYQQYFAIKEIIKTIEERDENGNRQSGVIWHTQGSGKSLTMVMLAKYILSELRGFNPKVIVVTDRVELDKQIHKTFSHTRLKASRATSGSHLVDLINDNHSDIVTTLVHKFDTASSKQKSIESRDIFVLVDESHRTQYGELHLKMKKVFPNACYLGFTGTPLMKKEKNTLIKFGKLIHKYTIADGVRDKAIVPLLYEGKMVEQSVNQKAIDHRLEMITRNLNDKQKEEVKQRWSKYEKLASSEQRIYLIAEDINKHFVENYKTQGSQFKAMLATNSKIEAIRYLEAFEELSDLNCAVVISPPDQREGHEVVDQESKDKVQRFWKRMMDRYGTPEKYEDAIKDEFVNGDELDLLIVVDKLLTGFDAPRATVLYVDKPMKEHTLLQAIARVNRLYEGKDYGLIIDYRGLLDKLDEAMQMYSGAGLENFDPEDLKGAIYDVISVIGSLRQYYSDLWQIFAPIKNKNDREEYEVWLEDEERREEFYGVLSNFGRNLGIALESEKIYNTLPPEELQKYKKDFKFFQDLRKSVKLRYSDTIDHKEYEAKMQKLMDNYIAAEEVIRITNPVDILNAKAFEEELERLESKRAKADAIRTRLTKSIHAKWDENPSYYKKFSERIQEAIQEYKDKRISEAEYLNRMKDIMNDYRRGESSERYPEIIKENRNAQAFYGVTKDILSETKETAATYDTNTLGDLALKIDEIIQEHQKVDWHDNVEIHNRIAQELDDLLFDFKEKHNLEIDFDTIDKIIEQIKTVALRRY
>NC_016023.1|WP_014095663.1|279835_281119_+|restriction-endonuclease-subunit-S
MNSQNILQQINAEAKFIENSIGYQKTKIGTIPKDWKVKKLKDISNRVQRKNDGKSHNVLTISSKGGFLNQTERFSKVIAGENLAKYILLRKNEFAYNKGNSKTYPYGCIYRLEDYEEALVPNVYYCFEIREGVTEFYKHYFITGKLNKFLARVINTGVRNDGLLNLNVTDFFDVPVAAPPIKEQQKIASILSTWDKAIELNEKLIEQKKKQKKGLMQKLLTGEVRLPGFEGEWGKFKIKEVCNVVSGGTPSTNDKKNWDGNIPWCTPTDITSSGKFIRNTKQTITEKGLKNSSANLLPKNSILMCSRATIGPRSINRVEMATNQGFKSFVCNEEYLDYEFFYYLLSIYIPIFKKLASGSTFLEVSKKDVENTKIFIPKDVKEQKAIGSIIGNLDKAIELLEEETKELKQQKKGLMQLLLTGKVRVKV
>NC_016023.1|WP_014095662.1|278297_279827_+|type-I-restriction-modification-system-subunit-M
MVEQTTQEKINSVLWQAADTFRGKIDSSTYKDYILTMLFIKYLSDTYKEKLEEYTKRYNGDEQRIQRALSRERFVLDETSTFDYLYSKRNDPEIGEIINKALERIENENSGKLRGVFRNIDFNSEAILGKAKERNAMLRSLLEDFNQLSLRPSQLGNEDIVGNAYQYMIGLFASDAGKKGGEFYTPAEVSELLARLVKPQENDRIYDPTCGSGSLLIKVAKQVPSKKVAIYGQERNGATHSLALMNMYLHGIDDAKIEWGDTLANPLHLEDGKLMKFQVIVANPPFSLDKWAMGFAGEGNTDKKFKMEASLDPYRRFEWGVPPSSKGDYAFVQHMLYSLAENGRMATILPHGVLFRGASEGKIRKQIIELNLLDAVIGLPEGLFYGTGIPACIMVFRKDRTRKDVLFIDASGEEHYEKGKNQNKLREQDIEKIVETYEKRETIDKYSYVATIDEIRENDYNLNIPRYVDTFEEEEPVDMEAVKENIANIKKELKEVEAQMEKYLKELGL
>NC_016023.1|WP_014095661.1|277704_278298_+|restriction-endonuclease-subunit-S
MLLGEIADIKTGLVLSRKKAEIEYTAKATYKLLSLKNISEDGFLENDSFEEFVSNDELEDHYFTKEGDVLMRLSQPYTAVCIDKEYSGLLIPSYFAIIKVDQSKVMPRYIAWYLNTWNVKKELERSQAGSRIPSTNQHVLKTIPIIAASLSKQKALIELYQLHQKEKRLYKKLIEEKELLFQGIAQQILSGKNQEEK
>NC_016023.1|WP_014095660.1|275476_276790_-|IS1380-like-element-ISBco1-family-transposase
MVTLTQKTLDFNHKIKLSNDGGSLSSDTGEFLFREFDEKIGFSKTLVKYLRLNDSRKYYLHSNENLLRQKVYQIIAGYAEDDAADQLTHDPVFKEIIETPTLASQPSLSRFYTRFDKDSIEQLNLANQEVLDKIHCFRQSKELFIDLDSTHSDTYGDQESSSYNTHYGTMGFHPLVAFDGATGDFLKAQLRPGNVYTSNGVVEFIRPLIKHYNEMFPETTLFLRGDSGFAVPGLYDLCEEESVLYIIRLKSNSQLQSLAKEYHPSSAPLDVSKTETYYEETIYQAKSWSKPRRVIIQSVRPAGELFFTHSFFVTNFELAFPQDIVRAYQKRGTMENYIKEAKNGFYFDHMNSHAFLVNEVKMMLTLLAYNLTNWLRTLCFPEGQKTMQIDTIRTRLIKAASKVVKSGRSLYFKLSSSFVYQNFFWDVLNRIQKLQLE
>NC_016023.1|WP_014095658.1|273603_274593_-|lactate-dehydrogenase
MRKVVAYETRADEFPLFQKFARKFDLDIKYVDDVLTPETAMKAMGAEAVTILGNYPVGAETFMALRDAGVKYIGLRTAGYNHIDQEAAKAYGIRFSNVAYSPYCVADFATMLILMCVRKAKQILSRVETQDFSVEGIQGREMHNLTIGIIGAGRIGSIVAKNLSGFGCNIIAHDTVERDELRGILKYVSLDELLKESDVITIHTPLFDRTYHMINQDRIAKMKDGVCIINCSRGAVVDTDALIAGIEAGKVGAAGIDVLEDEEGIFHYDRRTDILAHHQLAILRSFPNVIVTPHTAFYTDQAVSDMVEMALTSLVSFMETGKSRWEIKS
>NC_016023.1|WP_014095657.1|271526_272945_-|MFS-transporter
MVFNKKKINIVNIRQTKKSVFATGVGNAMEWFDFGLYSYLAVIISRNFFSAVENDELKLMFTFATFAIAFLMRPLGGVIFGRIGDKYGRKVVLTITIILMAFSTLLIGLLPTYDQIGIWAPVLLLVARIIQGFSTGGEYAGAMVYIAESSPDNKRNVLGSGLEIGTLAGYILASLLASTLFITLTDQQMATWGWRIPFLLGLPLGLVGFYLRAHLEETPIFENELSVEGVQEESFLSILKNHKKDILVCFVSVAFFNVTNYMLLSYMPSYLDEVIGLSSTAGTVLITLIMVIMVPLALLFGKLSDQIGNKTVLIMGLGGLTLLSVLAFYFIHLNTIAFVFLGILILGILLSTYEGTMPGTLPTMFYTDIRYRTLAVTFNVSVSLFGGTTPLISTWLVHQTGNALAPAFYLTFFSLIGFFVILFLFTSTSGKSLKGSYPTVATKTEYKEAIENPRHSLWWLMEKQEENKRLYN
>NC_016023.1|WP_014095656.1|269271_270195_+|SDR-family-oxidoreductase
MNIYEQQKNGQPAQTQPEQPGIESLMNPRPVQPLNYKGSEKLKGRVALITGGDSGIGRAVAIAYAKEGANVAINYLNEQNDAEETKSLVEAEGVQCLLLPGDVSQEATCKQLVEKTVAEFGKLDILVNNAGVQFPTEKIEDITHEQWDKTFRTNIYSVFYMCKYAVPHLKQGSAIISTASINPYVGNPKLLDYTATKGAIVGFTRSLAQNLASKGIRVNMVAPGPIWTPLIPSTFDEKTVESFGLKTPLGRPGQPADHAGAYVLLASDEGAYITGQCIHVNGGMAMSSDGKKLQKIFSAVFLTLPPK
>NC_016023.1|WP_014095655.1|268563_268839_-|hypothetical-protein
MHIEGNVIKGEFDKNRNEFSLQHVKQFVTVSTINANQFRSLYDYLKKHRDDHEGQILTLYDQMPVHLSAEDIHLFIEDLEKLQPLYHPEGM
>NC_016023.1|WP_035181994.1|289468_289765_-|WXG100-family-type-VII-secretion-target
MAGQIRMTPEELKAKAQRYGNAGQQIEQLLRDLTNLQNELRGEWEGRAFQGFDDQFNQLKPKVQNFAQLMHDINTQLNKTADAVAQHDEELSRNFGLQ
>NC_016023.1|WP_014095670.1|289997_291101_+|5-methyltetrahydropteroyltriglutamate---homocysteine-S-methyltransferase
MAKKTTPPFRADHVGSLLRPEKLKQARRRQESGEIPKEALRELENEEIKRIVEKQKEIGLQSVTDGEFRRAYWHFDFLENLTGVQGYESGGGIQFKEKQTKSHSIRIIGDLDFSGHPMIDDYKFLHSIAGDHTPKMTIPSPSMLHFRGKIAYGRYQADEDLFFHDLGKAYKKAIAAFYDAGCRYLQLDDTAWAYLCSDEQKEQLKARGLNPDHLEKLYARTINEAVSERPEDLTVTMHICRGNFRSTWIASGGYEPVAETLFNGLNIDGFFLEYDSDRAGGFEPLRHVQRKDLQIVLGLVTSKFGELENADDVKRRIDEASKYVPLEQLCLSPQCGFASTEEGNLLTEEEQWAKLSHVVKIAGEVWG
>NC_016023.1|WP_014095671.1|291186_292410_-|acetate-kinase
MKKIMAINAGSSSLKFKVFNMPDESILIGGVFERIGFDAPEVSYKINGFRQKEKPPIHDHRDAADYLIEILLKNHIVDDLNEISAVGHRITHGGSDFSDSAVLDRIVIQKIENLCELAPLHNPAGLLGIRTFMKRLPKACAVAVFDTSFHQTLAPETYLYPVPLKLYNEYHIRKYGFHGTNHQYVANEAALLLEKPLKDLKIISCHLGNGSSICAIQGGKSVNTSMGFTPLAGLMMGTRSGTVDPSIIPFIMKKTGQTIDEVMDMINKESGLLGISGISNDFRDVELAAKAHNEQAELAIKMFVNRVTECVGGYVALMGGVDAIVFTAGIGEHSASVRQAVVSNLAYLGAKLDFRSNEENGPYIHTPDSKVSLLVIPANEELMIARDTWRLSEGQAARLSEKQTVRV
>NC_016023.1|WP_014095672.1|292735_293614_+|PocR-ligand-binding-domain-containing-protein
MENKQQIEKVMEMFSSATGLTAVYVDIDGKEISDDDQFPPVCQIIRQVPHLRKHCQTCAKFGGFETMKNGQPCIYRCHAGLADFAVPVKSRENTLYGFIIGGQVRLEDDETQVKDFLQQQPLDLSSHRDFAAAYSKLPVFSLEKLSASAEVLGTLSEYYLSSVLNEEAKPAKESTAQVKKHASSKKEIKQALQYIQKHIHQPVTLEEVAGHVYLSPYYFSKLFKKETGETFVSFVNRQKMNLAKDMLANDDLPVSYIAHSLGFREISYFSKVFKRYYQTTPTSYRAMSRKKG
>NC_016023.1|WP_052301516.1|293947_294322_+|hypothetical-protein
MMRKNNRKTDDRKMATNLDNLFEIFYTIKTAEGRAPGTLKQYRENYQYFAVFLDKRGIPRNITDITRNTIRDYIRYMQTEVSELPSTYQPYGLIEVGASRLIVAFTSQRKLTELTLLFQEFCYL
>NC_016023.1|WP_014095674.1|294316_295435_-|helix-turn-helix-domain-containing-protein
MAKQNKAFKFRLLPNKEQSALLAKTFGCVRFVYNKMLAERKETYEKFKDDKELLKKQKFPTPAKYKSEFPFLKEVDSLALANAQMNLQTAYKNFFEGNADFPKFKNRKAKQSYTTNMVNGNIKLENGHIKLPKIKKPIKMKQHREIPADYKIKSCTISKTKTGKYYISILTEYEKDIRPVKIQKVVGLDFAMDGLYVESEQGKKANYPRYYRQALDKLAKAQRILSRRKKGSARWNKQRLVVAKLHEKVANQRMNFLHHKSKELASNFDAVVIEDLNMKGMSQALHFGKSVHDNGWGMFNTFLAYKLKEQGKQLVKIDKWFPSTKKCSCCGKEKEMPLSERVYKCSCGFVLDRDHNSAINIKNEGLRLLALS
>NC_016023.1|WP_014095675.1|295522_295663_+|hypothetical-protein
MREEKERVEIRMPKTILEKLEQYQKENGIPTRTGAILELLRKGLEK
>NC_016023.1|WP_014095677.1|296295_296772_+|Lrp/AsnC-family-transcriptional-regulator
MPRQYDGAAVQLDEIDRQIIQLLNGNGRISFTDLAKEVKLSRVAVQSRVHSLVENGVIKCFTAVVNPEKIGLHQSAFFNVEVEPKHLQEVAETLAKDPAVSSLYHMSGPSKLHMHGLFKDNEEMELFLKERLYPLPGIMSVDCQILLKRYKSRIGMKL
>NC_016023.1|WP_014095678.1|296784_297384_+|chromate-transporter
MEKQQNAYAQLAMAMLRTGILGYGGGPSVMPLFRYEAVTRYKWLDDDEFGETLAIANALPGPIATKMAAYLGYKLKKTTGAVFAILFHILPSSIAMIALLSLVSVLSHSKIVAGMIAGVMPVVAVMLGQMAYDFGEKTVKGLGKVFGIAMFVISFLLLETIHLHPAIVILIFLAYGSIHFRLVAKWRRDEKKKKRDEAG
>NC_016023.1|WP_014095679.1|297380_297920_+|chromate-transporter
MIWFQLMLGFFIANILGYGGGPSSIPLMYHEIVTHYGWLNDSEFSNMLALGNALPGPIATKIAAFVGYGAGGWTGLLAALAGTILPSAVALIVLLKVLHKYRQSPVVKGMSLLVQPVITIMMVVLTWQMAKSSFGQIGIWQSLGIAVVAFWAMHIRKIHPALVICAAFLYGGIVLQHIV

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Crispr_ID: NC_016023_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016023_2

320637-321284

Orphan

Consensus_repeat	Method
TTTTGAANCNGNCAAAAGGACAAAA	CRT

12 spacers

The CRISPR arrays of NC_016023_2

>merge|NC_016023|2|320637-321284|CRT
CATTGAAGTTGCCAAAAGGAAAAACAAGCTGCATCTGGATCCGAAATGTCCTTTTGAAGCCGTCAAAAGGACAAAACACGATGTATCCGGGCCCGAAATGTCCTTTTGTAACCGTCAAAAGGACAAAACACGCTGCATCCGGGCCCGAAATGTCTTTTTGAAGCCGTCAAAAGGACAAAACACGATGTATCCGGGCCCGAAATGTCCTTTTGTAACCGTCAAAAGGACAAAACACGCTGTTTCCGGGTCCGAAATGTCTTTTTGAACCTGCCAAAAGGACAAAACACGTTTCATCCGAGCTCGAAATGTCTTTTTGAAGCCGTCAAAAGGACAAAACACGTTTCATCCGAGCTCGAAATGTCTTTTTGAAGCCGTCAAAAGGACAAAACACGTTACGTCTGGATCCGAAATGTCCTTTTGAAGCCGTCAAAAGGACAAAACACGCTGCTTCCGGGTCCAAAATGTCTTTTTGAACCTGCCAAAAGGACAAAACACGTTACGTCTGGATCCGAAATGTCCCTTTGAACCTGCCAAAAGGACAAAAAAAGGATCGCGTTTGGGCCCAAATATCCTTTTGAACCTGTCAAAAGGACAAAAGGAGTCGCGACTGGATCAAAATGTCTTTTTGAAGTTGCCACACGGACAAAA

>NC_016023|2|1|320637-321284|CRT
CATTGAAGTTGCCAAAAGGAAAAAC	AAGCTGCATCTGGATCCGAAATGTCC
TTTTGAAGCCGTCAAAAGGACAAAA	CACGATGTATCCGGGCCCGAAATGTCC
TTTTGTAACCGTCAAAAGGACAAAA	CACGCTGCATCCGGGCCCGAAATGTCT
TTTTGAAGCCGTCAAAAGGACAAAA	CACGATGTATCCGGGCCCGAAATGTCC
TTTTGTAACCGTCAAAAGGACAAAA	CACGCTGTTTCCGGGTCCGAAATGTCT
TTTTGAACCTGCCAAAAGGACAAAA	CACGTTTCATCCGAGCTCGAAATGTCT
TTTTGAAGCCGTCAAAAGGACAAAA	CACGTTTCATCCGAGCTCGAAATGTCT
TTTTGAAGCCGTCAAAAGGACAAAA	CACGTTACGTCTGGATCCGAAATGTCC
TTTTGAAGCCGTCAAAAGGACAAAA	CACGCTGCTTCCGGGTCCAAAATGTCT
TTTTGAACCTGCCAAAAGGACAAAA	CACGTTACGTCTGGATCCGAAATGTCC
CTTTGAACCTGCCAAAAGGACAAAA	AAAGGATCGCGTTTGGGCCCAAATATCC
TTTTGAACCTGTCAAAAGGACAAAA	GGAGTCGCGACTGGATCAAAATGTCT
TTTTGAAGTTGCCACACGGACAAAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_016023.1\|WP_014095703.1\|321819_322176_-\|stage-V-sporulation-protein-AE	unknown	unknown	gnl\|CDD\|131886
NC_016023.1\|WP_014095700.1\|319455_319710_-\|hypothetical-protein	unknown	unknown	unknown
NC_016023.1\|WP_014095704.1\|322354_323365_-\|stage-V-sporulation-protein-AD	unknown	unknown	gnl\|CDD\|183504
NC_016023.1\|WP_014095702.1\|321591_321735_-\|YjcZ-family-sporulation-protein	unknown	unknown	unknown
NC_016023.1\|WP_014095695.1\|316532_316736_+\|hypothetical-protein	unknown	unknown	unknown
NC_016023.1\|WP_041817844.1\|327438_328218_-\|enoyl-ACP-reductase-FabI	unknown	unknown	gnl\|CDD\|236308
NC_016023.1\|WP_014095711.1\|326615_327308_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378716
NC_016023.1\|WP_014095692.1\|314338_314494_+\|hypothetical-protein	unknown	unknown	unknown
NC_016023.1\|WP_014095697.1\|317533_318265_+\|esterase-family-protein	unknown	unknown	gnl\|CDD\|225256
NC_016023.1\|WP_014095708.1\|324648_325005_-\|DUF1360-domain-containing-protein	unknown	unknown	gnl\|CDD\|369207
NC_016023.1\|WP_164931345.1\|316061_316232_+\|hypothetical-protein	unknown	unknown	unknown
NC_016023.1\|WP_014095699.1\|318850_319279_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379326
NC_016023.1\|WP_014095709.1\|325153_325594_+\|Spore-coat-protein-Z/Y	unknown	unknown	gnl\|CDD\|371163
NC_016023.1\|WP_014095696.1\|316971_317169_+\|hypothetical-protein	unknown	unknown	unknown
NC_016023.1\|WP_014095698.1\|318332_318845_+\|2'-5'-RNA-ligase-family-protein	unknown	unknown	gnl\|CDD\|184236
NC_016023.1\|WP_014095705.1\|323364_323841_-\|stage-V-sporulation-protein-AC	unknown	unknown	gnl\|CDD\|131885
NC_016023.1\|WP_014095706.1\|323857_324322_-\|sporulation-protein	unknown	unknown	gnl\|CDD\|293740
NC_016023.1\|WP_155641221.1\|315554_315701_+\|hypothetical-protein	unknown	unknown	unknown
NC_016023.1\|WP_014095710.1\|325642_326347_-\|spore-coat-CotO-family-protein	unknown	unknown	gnl\|CDD\|372932
NC_016023.1\|WP_014095701.1\|319811_320069_-\|stage-VI-sporulation-protein-F	unknown	unknown	gnl\|CDD\|372899

Protein	Function_ID	Function_description	E-value
NC_016023.1\|WP_014095703.1\|321819_322176_-\|stage-V-sporulation-protein-AE	gnl\|CDD\|131886	TIGR02839, stage_V_sporulation_protein_AE, stage V sporulation protein AE. This model describes stage V sporulation protein AE, a paralog of stage V sporulation protein AC. Both are proteins found to present in a species if and only if that species is one of the Firmicutes capable of endospore formation, as of the time of the publication of the genome of Carboxydothermus hydrogenoformans. Mutants in spoVAE have a stage V sproulation defect. [Cellular processes, Sporulation and germination].	4.44589e-45
NC_016023.1\|WP_014095704.1\|322354_323365_-\|stage-V-sporulation-protein-AD	gnl\|CDD\|183504	PRK12404, PRK12404, stage V sporulation protein AD; Provisional.	0
NC_016023.1\|WP_041817844.1\|327438_328218_-\|enoyl-ACP-reductase-FabI	gnl\|CDD\|236308	PRK08594, PRK08594, enoyl-[acyl-carrier-protein] reductase FabI.	4.22593e-166
NC_016023.1\|WP_014095711.1\|326615_327308_+\|hypothetical-protein	gnl\|CDD\|378716	pfam11780, DUF3318, Protein of unknown function (DUF3318). This is a bacterial family of uncharacterized proteins.	0.00401524
NC_016023.1\|WP_014095709.1\|325153_325594_+\|Spore-coat-protein-Z/Y	gnl\|CDD\|371163	pfam10612, Spore-coat_CotZ, Spore coat protein Z. This family has members annotated as Spore coat protein Z, otherwise known as CotZ, It is a cysteine-rich spore coat family, and along with CotY is necessary for assembly of intact exosporium.	3.22293e-25
NC_016023.1\|WP_014095699.1\|318850_319279_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379326	pfam13673, Acetyltransf_10, Acetyltransferase (GNAT) domain. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	4.86897e-20
NC_016023.1\|WP_014095708.1\|324648_325005_-\|DUF1360-domain-containing-protein	gnl\|CDD\|369207	pfam07098, DUF1360, Protein of unknown function (DUF1360). This family consists of several bacterial proteins of around 115 residues in length. Members of this family are found in Bacillus species and Streptomyces coelicolor, the function of the family is unknown.	2.28073e-49
NC_016023.1\|WP_014095698.1\|318332_318845_+\|2'-5'-RNA-ligase-family-protein	gnl\|CDD\|184236	PRK13679, PRK13679, hypothetical protein; Provisional.	2.38816e-91
NC_016023.1\|WP_014095701.1\|319811_320069_-\|stage-VI-sporulation-protein-F	gnl\|CDD\|372899	pfam14069, SpoVIF, Stage VI sporulation protein F. The sporulation-specific SpoVIF (YjcC) protein of Bacillus subtilis is essential for the development of heat-resistant spores. Its expression is governed by SigK.	1.01951e-23
NC_016023.1\|WP_014095706.1\|323857_324322_-\|sporulation-protein	gnl\|CDD\|293740	cd16016, AP-SPAP, SPAP is a subclass of alkaline phosphatase (AP). Alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH. Alkaline phosphatase exists as a dimer, each monomer binding 2 zinc atoms and one magnesium atom, which are essential for enzymatic activity. Although SPAP is a subclass of alkaline phosphatase, SPAP has many differences from other APs: 1) the catalytic residue is a threonine instead of serine, 2) there is no binding pocket for the third metal ion, and 3) the arginine residue forming bidentate hydrogen bonding is deleted in SPAP. A lysine and an asparagine residue, recruited together for the first time into the active site, bind the substrate phosphoryl group in a manner not observed before in any other AP.	0.00612061
NC_016023.1\|WP_014095697.1\|317533_318265_+\|esterase-family-protein	gnl\|CDD\|225256	COG2382, Fes, Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism].	3.37518e-77
NC_016023.1\|WP_014095710.1\|325642_326347_-\|spore-coat-CotO-family-protein	gnl\|CDD\|372932	pfam14153, Spore_coat_CotO, Spore coat protein CotO. Bacillus spores are protected by a protein shell consisting of over 50 different polypeptides, known as the coat. This family of proteins has an important morphogenetic role in coat assembly, it is involved in the assembly of at least 5 different coat proteins including CotB, CotG, CotS, CotSA and CotW. It is likely to act at a late stage of coat assembly.	2.23441e-56
NC_016023.1\|WP_014095705.1\|323364_323841_-\|stage-V-sporulation-protein-AC	gnl\|CDD\|131885	TIGR02838, stage_V_sporulation_protein_AC, stage V sporulation protein AC. This model describes stage V sporulation protein AC, a paralog of stage V sporulation protein AE. Both are proteins found to present in a species if and only if that species is one of the Firmicutes capable of endospore formation, as of the time of the publication of the genome of Carboxydothermus hydrogenoformans. Mutants in spoVAC have a stage V sproulation defect. [Cellular processes, Sporulation and germination].	4.21495e-68

>NC_016023.1|WP_014095701.1|319811_320069_-|stage-VI-sporulation-protein-F
MDHQFFKNIEKKTGVNMNDIFQLANSLQNANFKDENTVRGIIQRVSQIANKRVPKELEDKIVESIVKDGKKLDFNTINKMMNNGK
>NC_016023.1|WP_014095700.1|319455_319710_-|hypothetical-protein
MSLIAPIPDYQASQYRLYDGMSLRQLEVEKADAVSRAYPVKRQNGVTGGTEYHFKANEQPGRKPAKSRIIAKITGLGQYIDLSV
>NC_016023.1|WP_014095699.1|318850_319279_+|GNAT-family-N-acetyltransferase
MDVIIVENEEQLETAFQIRKKVFVEEQHVPVEEEIDALEQDCTHFLLYDDEGKPSGAGRFRMVDGYGKVERICILPSVRGKGAGRELMLAIEHYAAEQGVQKCKLNAQTHAIPFYEKLGYRVVSGEFLDAGIPHKAMEKTIK
>NC_016023.1|WP_014095698.1|318332_318845_+|2'-5'-RNA-ligase-family-protein
MNYALVVFPSKKLQDLVNSYRKRYDPKYALIPPHITLKAAFEASEEEAEVFRGQLKEIAKKYNPFLLKVTKVKSFEPVSNTIYFKVEPTPELEGLFADFRDRLPGGPPPYPFVPHITIGQELSKEEHADVFRQLEMVGIDHEEKVNRFHLLYQLENGVWTVYETYHLGKD
>NC_016023.1|WP_014095697.1|317533_318265_+|esterase-family-protein
MEIERGTIKDVPFESRELGETLNLWVYLPARFSPLYKYAVCICQDGKDFFQLGRIARAADELLAKGEIEDLIIVGIPYADIPDRRRKYHPDGEQHGAYIRFLAHELVPFLDREFPTAQMASDRALAGDSLAATVSLMAAFKYPHTFGKAALMSPLVNEKVMEAAKQCTDPKLLDIYHIAGKGETEVKTTDGKIQNFITPNRTLHQVLEEKGVPGFYDEFDGDHSWRYWQKDLPRALKYLFKKD
>NC_016023.1|WP_014095696.1|316971_317169_+|hypothetical-protein
MSSKKLFSDKRWTEPPGMTSDGKFTAIVSGTKHYASEEERQKDIETTRLIREMLKKRMKENNKNF
>NC_016023.1|WP_014095695.1|316532_316736_+|hypothetical-protein
MDKNNKPYSDRRWTDPIGITEDGEISAISIGTKHYASEEERQRDIEEGKKIRKEFLKMLKERHKNNK
>NC_016023.1|WP_164931345.1|316061_316232_+|hypothetical-protein
MGKKEKLFSAPRWTEPIGLKSDGSPSAISSGTKHYETEEERQKDIETTRYIREMLK
>NC_016023.1|WP_155641221.1|315554_315701_+|hypothetical-protein
MSPQKLDVGVKRWIFEVFKNGSKRFYLIEGGIPENDGRYPLEKVTLKK
>NC_016023.1|WP_014095692.1|314338_314494_+|hypothetical-protein
MKNDDKRISEGLNGWFEMMNAKGDKGEIAQIVEKYKARAADSNDAADQDKK
>NC_016023.1|WP_014095702.1|321591_321735_-|YjcZ-family-sporulation-protein
MFGYGYGCGYGYGGYGGGYGGGYGYGSTFVLIVVLFILLIIVGASFC
>NC_016023.1|WP_014095703.1|321819_322176_-|stage-V-sporulation-protein-AE
MLAMFFWAFVIGGLICVIGQLLFDVAKLSPGHTMSVLVTAGAILSGLGLYEPLVNFAGAGATIPITSFGNSLATGAMQEVQRHGIVGVLTGMFEVTSSGISAAIIFGFIGSLLFKPRG
>NC_016023.1|WP_014095704.1|322354_323365_-|stage-V-sporulation-protein-AD
MPAKSQTWTFTNRPAILSTGVVGGPFEKKGQMADDFDRFFEDLWIGEDSYEKAQRKLIEEAVGIALKKRNLKETDIQFFLAGDLINQITPTSFAARTNAIPYLGLFSACATSMESLALAAFIVNHGGAEKVLAGASSHNATTEKQFRYPTEYGGQKPPTAQWTVTGAGFAVVGTEENGPAPRITSATIGKVLDLGISDPFNMGGAMAPAAVDTIEQHLRETGRDPSYYDLIVTGDLAKIGRSIALDLFKQRNLDIRSEQFQDCGLMVYDKSQPVQAGASGAGCSAIVLYGHLLNEMKKGRYQKILLVATGALLSPLSYQQGETIPCIAHACAIEYL
>NC_016023.1|WP_014095705.1|323364_323841_-|stage-V-sporulation-protein-AC
MANKNQNKTPEQKAYDQFEKKHELKRPVLKNCIRAFWVGGCFCLAGQALTYFYIYMFNFTEKTAGNPTTATMVFLSMLLTGFGIYDHIGQYAGAGSAVPVTGFGNSVVSAAIEHRTEGYVLGVGGNIFKLAGTVIVFGVFSAFVVVLIRTVIMMWGGS
>NC_016023.1|WP_014095706.1|323857_324322_-|sporulation-protein
MKKIMYVLASVCLLTGCGFNGPEHKDSKMALVKKTQPSPVRLTNTGNKAVSGQLKKDVLGFDSIYDVAIIEGPKETLVAYKVRHLHRFKMKKIEKQLNAFLKKRYPGRKFITSSDYKIFLETVRLKEDMDEHKISAGKAKKRFKDIIKLKQELT
>NC_016023.1|WP_014095708.1|324648_325005_-|DUF1360-domain-containing-protein
MVSYWLDFVLLALASFRLTRLLVYDKITAFLRKPFHKEITEMAPDGTIEEYIEIKGTGIRKWIGELLSCHWCTGVWSAAILYGSWMLFPQIGSPIVMILAIAGLASILETVLLRIMDE
>NC_016023.1|WP_014095709.1|325153_325594_+|Spore-coat-protein-Z/Y
MSSKSHEYSRTCVCDVVHFINDLQDAAVEDSSCPTNCLNPVLGANREKHSHVNTRPFILYTKDGCAFEPFYKNHHFDSCDDFCEKSKFLRVENVEGCCAVVRVLKCVCEHHDGHSRVHFEATDTCITLDLTDFIAIQCLEDTFVNL
>NC_016023.1|WP_014095710.1|325642_326347_-|spore-coat-CotO-family-protein
MEESQYSSQKPLLYIIQPKNVPLAIKMQKVYRNVVSEKPEHAGHGTIVEPMPAGGDTGHAEEKNNAAAHEKKTEPEQPKPNKAAEQEKTEGAAERGGVVNVSSKTKTADPAEHEESANAMGQQHVAEPAGAVEAETDLETDGADKADTWPEQETIQPPSRKRFKEMTVHEKIDYLIHKPGFLPEIPVMIQTNSIAYRAVILERMEDQLSVMPFSSMETAWINLDEITDIKLLVQ
>NC_016023.1|WP_014095711.1|326615_327308_+|hypothetical-protein
MSYYDSNGSCYDDHRRHKRQDEEERGLLSEFDVDQSPSVPVPVTGVFNMANSIAEVDVKVDDYDDRVSLLATVEWSPADLPLGITLAALIAAVTGAATGTVIPLTIPATFRIWRRNSSGTTLISQKTDESVVSGIAILGTGGLVTLLFENVTTTVHAVDTDPSKGKNEYFLTIELGTFAPDTTIPGAAPTLLGTITLTPQNVVSYTFSAAEVEDNDHHDNKKGHKKDYRD
>NC_016023.1|WP_041817844.1|327438_328218_-|enoyl-ACP-reductase-FabI
MQLSLENKTFVVMGVANKRSIAWGIAQSLDAAGARIIFTYALDRNEKSIHELAETLNRKDYLILQCDVESDEQIQSCFQTIKKEVGTIDGIAHCVAFARREELKGDYTNVTREGFLLAHNISSYSLSAVAKAVKELELMPNGGSIVTLTYLGGERVMENYNVMGVAKASLDASVRYLAYDLGKLNIRVNSISAGPIRTLSAKGVSDFNSILKVMEERAPLHRGVDTREVGDTALFLFSDLSRAVTGENIHVDAGYHIMG

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Crispr_ID: NC_016023_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016023_3

635001-635092

Orphan

Consensus_repeat	Method
CCAAAGGCTTTGCAAGGGCTAGAAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_016023_3

>merge|NC_016023|3|635001-635092|CRISPRCasFinder
CCAAAGGCTTTGCAAGGGCTAGAACTTAGAAATGAGATTGGCAGCGTAGAACTATTTACAACTTTGTCCAAAGGTTTTGCAAGGGCTAGAAC

>NC_016023|3|2|635001-635092|CRISPRCasFinder
CCAAAGGCTTTGCAAGGGCTAGAAC	TTAGAAATGAGATTGGCAGCGTAGAACTATTTACAACTTTGT
CCAAAGGTTTTGCAAGGGCTAGAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_016023.1\|WP_014095964.1\|624012_624198_+\|Fur-regulated-basic-protein-FbpA	unknown	unknown	gnl\|CDD\|315692
NC_016023.1\|WP_187287748.1\|638069_638864_+\|AAC(3)-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|376807
NC_016023.1\|WP_014095979.1\|641655_643179_-\|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl\|CDD\|235730
NC_016023.1\|WP_014095982.1\|645289_645466_-\|hypothetical-protein	unknown	unknown	unknown
NC_016023.1\|WP_041818209.1\|619952_620897_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381329
NC_016023.1\|WP_014095981.1\|644627_645209_+\|biotin-transporter-BioY	unknown	unknown	gnl\|CDD\|376871
NC_016023.1\|WP_014095965.1\|624506_625286_-\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|319819
NC_016023.1\|WP_014095969.1\|628978_630040_-\|NAD(P)-dependent-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|176188
NC_016023.1\|WP_014095971.1\|633085_634237_+\|radical-SAM/CxCxxxxC-motif-protein-YfkAB	unknown	unknown	gnl\|CDD\|275271
NC_016023.1\|WP_014095963.1\|623205_623970_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|224561
NC_016023.1\|WP_014095966.1\|625314_625857_-\|SIS-domain-containing-protein	unknown	unknown	gnl\|CDD\|240138
NC_016023.1\|WP_014095980.1\|643175_643562_-\|MerR-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133403
NC_016023.1\|WP_014095974.1\|635648_636074_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NC_016023.1\|WP_014095972.1\|634387_634915_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|370723
NC_016023.1\|WP_044051928.1\|639026_639926_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235853
NC_016023.1\|WP_014095967.1\|625989_626949_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380509
NC_016023.1\|WP_014095978.1\|640013_641672_-\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173843
NC_016023.1\|WP_014095975.1\|636601_637930_-\|polysaccharide-biosynthesis-protein	unknown	unknown	gnl\|CDD\|240529
NC_016023.1\|WP_052301520.1\|620948_623159_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|180751
NC_016023.1\|WP_014095973.1\|635241_635448_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_016023.1\|WP_014095964.1\|624012_624198_+\|Fur-regulated-basic-protein-FbpA	gnl\|CDD\|315692	pfam13076, Fur_reg_FbpA, Fur-regulated basic protein A. This family of proteins is regulated by the ferric uptake regulator protein Fur. This family does not regulate the lutABC operon encoding iron sulfur-containing enzymes necessary for growth on lactate.	5.7044e-08
NC_016023.1\|WP_187287748.1\|638069_638864_+\|AAC(3)-family-N-acetyltransferase	gnl\|CDD\|376807	pfam02522, Antibiotic_NAT, Aminoglycoside 3-N-acetyltransferase. This family consists of bacterial aminoglycoside 3-N-acetyltransferases EC:2.3.1.81, these catalyze the reaction: Acetyl-Co + a 2-deoxystreptamine antibiotic <=> CoA + N3'-acetyl-2-deoxystreptamine antibiotic. The enzyme can use a range of antibiotics with 2-deoxystreptamine rings as acceptor for its acetyltransferase activity, this inactivates and confers resistance to gentamicin, kanamycin, tobramycin, neomycin and apramycin amongst others.	7.49358e-113
NC_016023.1\|WP_014095979.1\|641655_643179_-\|long-chain-fatty-acid--CoA-ligase	gnl\|CDD\|235730	PRK06187, PRK06187, long-chain-fatty-acid--CoA ligase; Validated.	3.3098e-166
NC_016023.1\|WP_041818209.1\|619952_620897_+\|aldo/keto-reductase	gnl\|CDD\|381329	cd19103, AKR_unchar, uncharacterized aldo-keto reductase (AKR) superfamily protein. This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.	2.33474e-176
NC_016023.1\|WP_014095981.1\|644627_645209_+\|biotin-transporter-BioY	gnl\|CDD\|376871	pfam02632, BioY, BioY family. A number of bacterial genes are involved in bioconversion of pimelate into dethiobiotin. BioY is a component of the BioMNY transport system involved in biotin uptake in prokaryotes.	3.72844e-35
NC_016023.1\|WP_014095965.1\|624506_625286_-\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|319819	cd07517, HAD_HPP, phosphatase, similar to Bacteroides thetaiotaomicron VPI-5482 BT4131 hexose phosphate phosphatase; belongs to the haloacid dehalogenase-like superfamily. Bacteroides thetaiotaomicron VPI-5482 BT4131 is a phosphatase with preference for hexose phosphates. In addition this family includes uncharacterized Bacillus subtilis YkrA, a putative phosphatase and uncharacterized Streptococcus pyogenes MGAS10394 a putative bifunctional phosphatase/peptidyl-prolyl cis-trans isomerase. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	4.7271e-91
NC_016023.1\|WP_014095969.1\|628978_630040_-\|NAD(P)-dependent-alcohol-dehydrogenase	gnl\|CDD\|176188	cd05285, sorbitol_DH, Sorbitol dehydrogenase. Sorbitol and aldose reductase are NAD(+) binding proteins of the polyol pathway, which interconverts glucose and fructose. Sorbitol dehydrogenase is tetrameric and has a single catalytic zinc per subunit. Aldose reductase catalyzes the NADP(H)-dependent conversion of glucose to sorbital, and SDH uses NAD(H) in the conversion of sorbitol to fructose. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. The medium chain alcohol dehydrogenase family (MDR) have a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit.	1.79304e-178
NC_016023.1\|WP_014095971.1\|633085_634237_+\|radical-SAM/CxCxxxxC-motif-protein-YfkAB	gnl\|CDD\|275271	TIGR04478, radical_SAM_superfamily_domain_protein, radical SAM/CxCxxxxC motif protein YfkAB. Members of this highly conserved family in some Firmicutes have an N-terminal radical SAM domain (pfam04055) and a C-terminal pfam08756 domain with a CxCxxxxC motif that suggests binding to an additional metallocluster. It appears all correct sequences in this family are about 370 amino acids in length, containing the YfkA and YfkB regions originally reported as separate ORFs in Bacillus subtilis. Partial Phylogenetic Profiling shows occurrences almost exclusively in the Bacilli, with very few examples of either lateral transfer or gene loss. The essentially monophyletic distribution suggests a housekeeping function. Members have no well-conserved gene neighborhood. The function is unknown. [Unknown function, Enzymes of unknown specificity].	0
NC_016023.1\|WP_014095963.1\|623205_623970_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|224561	COG1647, COG1647, Esterase/lipase [General function prediction only].	2.46148e-41
NC_016023.1\|WP_014095966.1\|625314_625857_-\|SIS-domain-containing-protein	gnl\|CDD\|240138	cd05005, SIS_PHI, Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with formadelhyde to become hexulose-6-phosphate, which is then isomerized to fructose-6-phosphate by PHI.	3.66029e-41
NC_016023.1\|WP_014095980.1\|643175_643562_-\|MerR-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|133403	cd04776, HTH_GnyR, Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR. Putative helix-turn-helix (HTH) regulatory protein, GnyR, and other related proteins. GnyR belongs to the gnyRDBHAL cluster, which is involved in acyclic isoprenoid degradation in Pseudomonas aeruginosa. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules.	1.57933e-36
NC_016023.1\|WP_014095974.1\|635648_636074_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	3.50502e-34
NC_016023.1\|WP_014095972.1\|634387_634915_+\|hypothetical-protein	gnl\|CDD\|370723	pfam09849, DUF2076, Uncharacterized protein conserved in bacteria (DUF2076). This domain, found in various hypothetical prokaryotic proteins, has no known function. The domain, however, is found in various periplasmic ligand-binding sensor proteins.	0.00618684
NC_016023.1\|WP_044051928.1\|639026_639926_-\|SDR-family-oxidoreductase	gnl\|CDD\|235853	PRK06701, PRK06701, short chain dehydrogenase; Provisional.	4.41416e-164
NC_016023.1\|WP_014095978.1\|640013_641672_-\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173843	cd01154, AidB, Proteins involved in DNA damage response, similar to the AidB gene product. AidB is one of several genes involved in the SOS adaptive response to DNA alkylation damage, whose expression is activated by the Ada protein. Its function has not been entirely elucidated; however, it is similar in sequence and function to acyl-CoA dehydrogenases. It has been proposed that aidB directly destroys DNA alkylating agents such as nitrosoguanidines (nitrosated amides) or their reaction intermediates.	7.63366e-147
NC_016023.1\|WP_014095975.1\|636601_637930_-\|polysaccharide-biosynthesis-protein	gnl\|CDD\|240529	cd13124, MATE_SpoVB_like, Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins. The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	2.14197e-88
NC_016023.1\|WP_052301520.1\|620948_623159_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|180751	PRK06922, PRK06922, class I SAM-dependent methyltransferase.	0
NC_016023.1\|WP_014095967.1\|625989_626949_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|380509	cd06286, PBP1_CcpB-like, ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species. This group includes the ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species. Catabolite control protein B (CcpB) is 30% identical in sequence to CcpA which functions as the major transcriptional regulator of carbon catabolite repression/regulation (CCR), a process in which enzymes necessary for the metabolism of alternative sugars are inhibited in the presence of glucose. Like CcpA, the DNA-binding protein CcpB exerts its catabolite-repressing effect by a mechanism dependent on the presence of HPr(Ser-P), the small phosphocarrier proteins of the phosphoenolpyruvate-sugar phosphotransferase system, but with a less significant degree.	2.26256e-117

>NC_016023.1|WP_014095972.1|634387_634915_+|hypothetical-protein
MGWFIGIIIIILLVYFLIIRPLIERNRPQIIEPRRSIYNGDAYDPHPEQTGWNDGGNAGIGRFGMFAGGMATGALLTYLLEQGRIGLDQFEHFQNLDGNDLLQELEEQNILQQDEIDHLQDTLSNFEDNGHDGHDDGNHGDHDQQDAGFDLADFSSNDDNDFGGWDSGSDDNNWL
>NC_016023.1|WP_014095971.1|633085_634237_+|radical-SAM/CxCxxxxC-motif-protein-YfkAB
MLKEETQRSITPEYDPWEAYMDITTHGKLTLSNIEFTTTTLCNMRCEHCAVGYTLQPKDPDALPLDLLLRRLDEISTLRCISITGGEPMLSTKSVENYVLPLLQYAHERGIRTQINSNLTMKLEKYVQIAPYLDVLHISHNWGTVRDYIDGGFANMRIKPSDQHGEKLFRRIVENSRALSEMGVMVSAETMLNKRTLPYMEQIHHQIVEEMKCARHEIHPMYPSDFAADLEVLSLDEIREAIHHLLDIRDESVWMLFGTLPFYPCSPNPEDQALLKRLYESKNVTLRNDPDGRSRLNVNIFTGDVIVTDFGDTPPLGNIQHDRLPDVFEKWLETPIAKSLNCHCPQVKCLGPNILVKNAYYKNIDFTQRKAVIDMQGASSRMG
>NC_016023.1|WP_014095969.1|628978_630040_-|NAD(P)-dependent-alcohol-dehydrogenase
MTNHIPETMKAAVMHGTRNISIETLPVPQIEENEVLIKVMAVGICGSDLHYYETGRIGKYVVDKPFILGHECAGEIAAVGSKVRHFKVGDRVAVEPSVTCGHCEACKEGRYNLCPHVQFLATPPVDGAFCQYIKMREDFVFAIPDALSYEEASLVEPFSVGIHAATRTKLQPGSTVAIMGMGPVGLMAVVAARAFGASNIIVTDLEPLRLKAAKEMGATYAINIREQDPYEAIQDITNGKGVDVAWETAGNPAALQSALASVRRGGKLAIVGLPAQNEIPLNVPFIADNEIDIYGVFRYANTYPKGINFLASGIADVKKLVTDQYALEDTYQAMERALNFKNECLKVMIYPNS
>NC_016023.1|WP_014095967.1|625989_626949_-|LacI-family-DNA-binding-transcriptional-regulator
MTNIRDLAKMAGVSVTTVSRVLNNHPYVSEEKKNAVLKAVKATRYHKNINAVHLSKGKTKLIGVVLPFTDHPYFALLLKGIAKQALEYNHKLLLFQTDYMESRETEALQMLQQKQIDGLIICSRACSMRKIEEYLPFGPIALCECVKGGEISSTYIDHYKIFMDALEFLYRKGHTKIGYCIGRKSGTNSRNRDKAYWDFHEKYHLPHHPEYIFDQCYDYEDGERVLSRVKEMDPPPSALLVTSDQVAAGIVISCNKQQISIPDELAIIGFDNEPIAGMLNITTIDIPLVEMGRNLVHQVLTKEIKNKEISATLIERGTV
>NC_016023.1|WP_014095966.1|625314_625857_-|SIS-domain-containing-protein
MNILEDAKAMVLELYASLCSKVDDQPLEQVVEVIGRSNRLFLAGTGCSEMILRVFANRLVHLGFRVGMIGDLISPVPKKGDTILFSSKSGENPVLLNAARKAKLHGINIVAITASPASTLAKMADVTVLLPDESSEFESIKQAGLTPDRIGTLFELLSFLIYDVITASLMKKRHPENEYA
>NC_016023.1|WP_014095965.1|624506_625286_-|Cof-type-HAD-IIB-family-hydrolase
MKQQSVIFFDIDGTLLTHEKKLPVTTKKAIDKLKSDGHVTAIATGRAPFMFEDLRKELGMDTFVSYNGQYVVMNGEVLFKNPLNRQSLEELTAYALSHQHPLVYMDHEDMKANVPNHEDIEKSITSLKIGRLPAYDPHYYKGRELYQALLFCSEGEEKQYEQAFPDFEFIRWHPLSVDVLPKGGSKARGIEKIVEKLGFPPERQYAFGDGLNDIKMLSMIKNSVAMGNAEEKVKAAAKYITKSVEDMGIPHGLQIVGLL
>NC_016023.1|WP_014095964.1|624012_624198_+|Fur-regulated-basic-protein-FbpA
MKNFLRHAIEKKRQYLIEQLIALGAYQEDDKQLFTLTLTELETEYAYFSKISQEKEASGRE
>NC_016023.1|WP_014095963.1|623205_623970_+|alpha/beta-fold-hydrolase
MHEYYPVLSGAESFFIKGNEIGILISHGFNGTPQSVRFLGEALASDGFTVCAPRLKGHGTHILDMERCTYKDWIASLEEGYQLLKRHCHDIFVIGQSMGGTLALHLAEKHPDIRGIVCINAAIQSIPELEKCLAKGRFIQEGPPDIKAAGVHEISYEKVPVASIRELLSVMWETRENLSAIHCPALLFQSTEDHVVPPENTEYIAAHIHASRKKIVPLRNSYHVATMDHEKEWIAAQCSLFVQEIAHIETRTEI
>NC_016023.1|WP_052301520.1|620948_623159_+|class-I-SAM-dependent-methyltransferase
MADLLSSLKLIAKAKAGNTDILHEHKWLSYLYRTDEKNVNLEQVESLENLEPNPVLHYVEKTLAILDRCYADLPASEKEIIEEVLRWSEVAKCGSAQKREEWRRRGFQLRIHNIGSARIYAHEQMAVPFGQRHLQKEDLIYTLILTHGLVGQFIRGEVRYRQLYPLIDWIQSHRSSLKWDIKRILLALNHCIIEGVSPAIWEKVRAETSQITSWIAAGEKSREHSLKERLRRLRECSIQKGEDFEALYTKWFSNRELASMFHLLFQKTDIWYVESALQDFSFEEFLKIFLLVYQKTNLLTVEQISFEPLMKDIYYDYKGKKSVNLYKKRIIEAYLKACPLAGLISGDTQPNEHVTLELIPFDSLGSTTGVNFTFSKPGEKLIAFCQEAEKSPLYERSILLLYDFFGFRKDAFDRLQNEQHYLADMNNAEDHKKIIADFAKGTVMIDVGAGGGIMLDLLSEKHPDADITGIDISTNVIQELERKKVRERKSWKVKQADALKLSSYFELESADTIIFSSILHEMYSYIPFHGRTYNPDVVKAALKSAFAVLKPGGRMIIRDGIMTEPKDLIRLLAFRDPDGFRFFTRYVEDFKGRKIDYEITEDNKIKLPVNDLMEFLYTYTWGEEAYPHEVQEQFGYFTPSEYRKVIEETLGSRANIICFRHYLQEGYSTHLLPKVKVMDESGKLSLKRRNKPSSGLLREKRLLQAASLHPSVFYLTYSILPIKHTLQLGLIGLKLC
>NC_016023.1|WP_041818209.1|619952_620897_+|aldo/keto-reductase
MQNDKIPPIALGTWSWGTGANGGDTVFGNHLTAADLKPVFDAAMDAGLNLWDTAAVYGMGASETILGRFIRERGDTLISTKFTPGGEQDDNAVETFLEGSLERLGVDHVDLYWIHNPGDVKRWTPKLIPLMKSGKIKHVGVSNHNLEEIKLAADILAAEGLKLSAVQNHYSLLYRSSEEAGILDYCNQNGILFFPYMVLEQGALTGKYGPQNPFPAGTRRGDAFTPDVLSKLEDLIRVMKKIGSKYETGPAQITIAWAIAKGTVPIIGVTKVSQIEDAVSATEVHLTEQEIRELEAAAKATGVEIKGAWEKPMH
>NC_016023.1|WP_014095973.1|635241_635448_-|hypothetical-protein
MNENKKKSQRKMDNPEQFATENEDMHDKFMSEQTVDPIPMEDLREEKLEEKTDHDKKTTSSSEKKYKP
>NC_016023.1|WP_014095974.1|635648_636074_+|universal-stress-protein
MFNRILVAIDGSKMSEKALKSALNFAKERFTKIGVIHVEKNPVIPEGMPNASIDTLYSEQQRDGDDLLDQAAALAEEEEIEIEKFYETGDPAAQIVRKAEEGNYQLIIMGSRGLGNLKGLMLGSVSQKVTQLAKCPVLIIK
>NC_016023.1|WP_014095975.1|636601_637930_-|polysaccharide-biosynthesis-protein
MAVFFKGAFMLIGVAFIGECIEFLTNMVLANELGAHGMGLYMSILPAIFLIVTIASMELPISISKFVAEKEEKYHRDMLRFTIRLASLFVLLLMAAVALLLPALPIFHHYHPYLRWLIIALIPMIAFSSIARGYFMGVQQMGKIAAANFLRKMMQLILLVLLFHWMEFDVQMSIFIAICTLVGSDLIVLLYLFHMFVLQMRTLKKKEQAPMGGKEIRRSLLSVSLSTTGMRVFHAVTNAIEPFFIKWVLLKSGMTEGMANEHFGLVAGVAFTIGFFPAFIAHSLSTVLIPTVSEAYAKRDGIKLQKLLQQVMMMTFLYGLPAVIVIQVFSVPLTTLFSHSAAAAVYVRLLWPYFLFHYFVIPMQAFLIGLGLVRDALAHFIWSTMVTYCLIYYLGSNPQYQMAGVIIAMNTGTLLIMMMHYLTICKKIEISLILRKSMKHTF
>NC_016023.1|WP_187287748.1|638069_638864_+|AAC(3)-family-N-acetyltransferase
MLVTKERLVTDFRKLGLKEGMVVIVHSSLSALGWVCGGEVAVILALMEVVTERGTIVMPAQTANNTDPAFWENPPVPEAWWEEIRRSMPAFDPAVTPTYGMGRVAELFRTFPGVLRSHHPTCSFTAWGREAKSILSGHSLDFPFGEKSPLAQIYDRDGCILLLGVDYHANTSMHLGESRSKHTKRCTQSCAMTINGKRVWQSYEDYEENSDLFNKIGRAFERSHQVKTGFIGAAPSKLIKQRALVDFTAQYLDELYTDTEKAHR
>NC_016023.1|WP_044051928.1|639026_639926_-|SDR-family-oxidoreductase
MYFSRTEPGYRIHPQKYAFPPQHQPKQPGIEKLMHPRPQIEDSSYKGSGKLENKVAIVTGGDSGIGAATAIAFAKEGADVVIPYFSNYEIEDASRTKRRIEALGQRCLLIPGDLKDPEHCQNVVKQTVDTFGHLDVLVNNHAMQFVQKDLQDITNEQWDFTFKNNIHSFFYLVKAALPYLKAGSSIIFTSSVTAYEGSRNLIDYSATKGAIVAFTRSLSQNLVRKGIRVNAVAPGPIWTPLIPSSFYPEQVAKFGLDVPMKRAGQPYELAPTYVYLASRDSSYVTGQVLHVNGGTITDS
>NC_016023.1|WP_014095978.1|640013_641672_-|acyl-CoA-dehydrogenase-family-protein
MNFYHDDPNLARLLKQYLDPLFFDWAEKELAEFGEMCAGEIDERATHTDREGQPKLIKYNRYGEDVSRVWVNEGYFKTVEQVYNKGIVGYVHKPIPALGQKGNYVYAFAQGYLLSQSELGFYCPVTLTAAASYLLDHYGSHELKQTYLPQLISTGEAERYEGATFLTERQGGSDVGANETKAVSEDGCYRLYGEKYFASNVGMCGVAMVLARREGAPSGTKGLSLFLVPWEKENGEKNGIYIRRLKDKLGVRAVPSGEVVFDGAKAYLVGDPRKGFYYMMEALNLSRICNAVASIGIMRRAYREARAYALRRTAFGSRLADYPMVKETLVKMAAKQEVETSAVFRLATLFDRTASGKADEKENIMARLLIAILKMETAEQAIHFAHEAIEMHGGNGYIEDFVTPRLLRDAQVLTVWEGTANILGLEVLRLMRKFKVHDIFIGMMREKIDQLQAGTWLSAGLEQLEETCRFVMKAKEEAVQTYHCKKVARQMVKIYESVTALEDALAGQRQKWIAEAYLRLAWHDPLAIDPELALVKHFEEIVMEKVPANEGN
>NC_016023.1|WP_014095979.1|641655_643179_-|long-chain-fatty-acid--CoA-ligase
MNISELLARNARKYPQQEALVSPRERLNYQELNVRVNRLAHALQNCNFKQGDRAVIVMPNTNAFVIAYFAVMRLGGIVVPVNAKSSRAELEYMLDDSGANVLFVHELLFEELKEATFPPHLVKIKTGERVTGCQIFEEMINHSPETEIRCRLKEDDDASILYTSGTTGKPKGVLFTNRNILSAAWMMCVEMAMKPESRILHMMPLSHSAPLHLFLVAGTVVGATHVLSPVFTPEALVETVEKERITHFFGAPVAYLFTAKLPNLQDYDLSTMKYWVYGGAPLSRPEVGLIQNAFRSDRLVCVYGLTEAGPNGTLLLPEEHAEKAGSIGKRAALGMEIRLVNEKGEDVAAGEVGEIALYGESVMKGYFRKPEETNRVFQNGWLLTGDMARKDEEGYYWVVDRKKDMILSGGVNVYPKEIEDVLVTHPKIREVSVIGVPHPEWGETVKAFLVLAEPMDNIEEECKRFLKGKLASYKIPKLYERIEELPRNATGKIQKQVLRGMANELLP
>NC_016023.1|WP_014095980.1|643175_643562_-|MerR-family-DNA-binding-transcriptional-regulator
MTCKISELAAEFGVSTRTIRYYEELGLFKPKRSQNGRRCYSKKDYTRLKLIFRGKQLDFSLDEIKEMIELFDCDRSGIKQLEKTIEYGKQKRREVAQQIQNLQELQSELEKYLAEFETRLKRLKEEQG
>NC_016023.1|WP_014095981.1|644627_645209_+|biotin-transporter-BioY
MAAKKFRAIDLCYAGMFAALMAIGANITSIAPFLVIGGVPITLQTFFAVLAGLVLGSRLGAISMVAYMLIGLLGAPVFAQFSGGFQTVLSPTFGFILSFIPAAWATGKIVEKRQNLTTYFIAAIIGLILNYLIGTNWMYAAYKIWAQAPQAFSYKIAWVWMAVPLPKDIILSLVAGWLAHRIKAVSPLIALKR
>NC_016023.1|WP_014095982.1|645289_645466_-|hypothetical-protein
MHLERSRRFNAVNGEMPCSGILSHPKNAPFQAAAAGSDLIVKRGSEVCIWKDPVVLTQ

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Crispr_ID: NC_016023_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016023_4

720147-720227

Orphan

Consensus_repeat	Method
AAACCCGGACTTGCAAGCACGCCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_016023_4

>merge|NC_016023|4|720147-720227|CRISPRCasFinder
AAACCCGGACTTGCAAGCACGCCAACTGGTGATGCAGGTACATTCGAAGGAAAGGTGAAACCCGGACTTGCAAGCACGCCA

>NC_016023|4|3|720147-720227|CRISPRCasFinder
AAACCCGGACTTGCAAGCACGCCA	ACTGGTGATGCAGGTACATTCGAAGGAAAGGTG
AAACCCGGACTTGCAAGCACGCCA

Protein	Signature genes	Signature genes Name	Protein_function
NC_016023.1\|WP_014096036.1\|710955_711768_-\|teichoic-acids-export-ABC-transporter-ATP-binding-subunit-TagH	unknown	unknown	gnl\|CDD\|184131
NC_016023.1\|WP_014096048.1\|727402_729697_+\|glycoside-hydrolase-family-65-protein	unknown	unknown	gnl\|CDD\|224471
NC_016023.1\|WP_014096034.1\|709543_709828_+\|cytochrome-aa3-quinol-oxidase-subunit-IV	unknown	unknown	gnl\|CDD\|200218
NC_016023.1\|WP_014096043.1\|721798_722524_-\|WecB/TagA/CpsF-family-glycosyltransferase	unknown	unknown	gnl\|CDD\|224833
NC_016023.1\|WP_014096041.1\|720304_721291_-\|acryloyl-CoA-reductase	unknown	unknown	gnl\|CDD\|176249
NC_016023.1\|WP_014096047.1\|726365_727193_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_016023.1\|WP_014096030.1\|705032_705692_-\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|319859
NC_016023.1\|WP_014096049.1\|729842_731018_-\|cystathionine-beta-lyase	unknown	unknown	gnl\|CDD\|236146
NC_016023.1\|WP_014096033.1\|708935_709544_+\|cytochrome-aa3-quinol-oxidase-subunit-III	unknown	unknown	gnl\|CDD\|239214
NC_016023.1\|WP_014096039.1\|717337_719083_-\|phospho-sugar-mutase	unknown	unknown	gnl\|CDD\|100092
NC_016023.1\|WP_014096045.1\|723708_724953_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270453
NC_016023.1\|WP_014096031.1\|706038_706965_+\|cytochrome-aa3-quinol-oxidase-subunit-II	unknown	unknown	gnl\|CDD\|273621
NC_016023.1\|WP_014096032.1\|706989_708939_+\|cytochrome-aa3-quinol-oxidase-subunit-I	unknown	unknown	gnl\|CDD\|131928
NC_016023.1\|WP_014096046.1\|725138_726353_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NC_016023.1\|WP_014096035.1\|710002_710746_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|212491
NC_016023.1\|WP_041818213.1\|731014_732130_-\|methionine-biosynthesis-PLP-dependent-protein	unknown	unknown	gnl\|CDD\|181320
NC_016023.1\|WP_035200705.1\|711835_712321_-\|VanZ-family-protein	unknown	unknown	gnl\|CDD\|227939
NC_016023.1\|WP_014096038.1\|712513_716935_-\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173801
NC_016023.1\|WP_014096044.1\|722846_723593_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|274977
NC_016023.1\|WP_014096042.1\|721307_721622_-\|iron-sulfur-cluster-biosynthesis-family-protein	unknown	unknown	gnl\|CDD\|366687

Protein	Function_ID	Function_description	E-value
NC_016023.1\|WP_014096036.1\|710955_711768_-\|teichoic-acids-export-ABC-transporter-ATP-binding-subunit-TagH	gnl\|CDD\|184131	PRK13546, PRK13546, teichoic acids export ABC transporter ATP-binding subunit TagH.	4.7996e-129
NC_016023.1\|WP_014096048.1\|727402_729697_+\|glycoside-hydrolase-family-65-protein	gnl\|CDD\|224471	COG1554, ATH1, Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism].	0
NC_016023.1\|WP_014096034.1\|709543_709828_+\|cytochrome-aa3-quinol-oxidase-subunit-IV	gnl\|CDD\|200218	TIGR02901, cytochrome_aa3_quinol_oxidase_subunit_IV, cytochrome aa3 quinol oxidase, subunit IV. This family (QoxD) encodes subunit IV of the aa3-type quinone oxidase, one of several bacterial terminal oxidases. This complex couples oxidation of reduced quinones with the reduction of molecular oxygen to water and the pumping of protons to form a proton gradient utilized for ATP production. aa3-type oxidases contain two heme a cofactors as well as copper atoms in the active site. [Energy metabolism, Electron transport].	1.88616e-26
NC_016023.1\|WP_014096043.1\|721798_722524_-\|WecB/TagA/CpsF-family-glycosyltransferase	gnl\|CDD\|224833	COG1922, WecG, Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane].	1.52389e-79
NC_016023.1\|WP_014096041.1\|720304_721291_-\|acryloyl-CoA-reductase	gnl\|CDD\|176249	cd08289, MDR_yhfp_like, Yhfp putative quinone oxidoreductases. yhfp putative quinone oxidoreductases (QOR). QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR actin the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site, and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	1.58841e-174
NC_016023.1\|WP_014096047.1\|726365_727193_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	6.72631e-79
NC_016023.1\|WP_014096030.1\|705032_705692_-\|HAD-family-hydrolase	gnl\|CDD\|319859	cd16423, HAD_BPGM-like, uncharacterized subfamily of beta-phosphoglucomutase-like family, similar to uncharacterized Bacillus subtilis YhcW. This subfamily includes the uncharacterized Bacillus subtilis YhcW. It belongs to the beta-phosphoglucomutase-like family whose other members include Lactococcus lactis beta-PGM, a mutase which catalyzes the interconversion of beta-D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), Saccharomyces cerevisiae phosphatases GPP1 and GPP2 that dephosphorylate DL-glycerol-3-phosphate and DOG1 and DOG2 that dephosphorylate 2-deoxyglucose-6-phosphate, and Escherichia coli 6-phosphogluconate phosphatase YieH. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	3.26976e-63
NC_016023.1\|WP_014096049.1\|729842_731018_-\|cystathionine-beta-lyase	gnl\|CDD\|236146	PRK08064, PRK08064, cystathionine beta-lyase MetC.	0
NC_016023.1\|WP_014096033.1\|708935_709544_+\|cytochrome-aa3-quinol-oxidase-subunit-III	gnl\|CDD\|239214	cd02863, Ubiquinol_oxidase_III, Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. Ubiquinol oxidases feature four subunits in contrast to the 13 subunit bovine cytochrome c oxidase (CcO). Subunits I, II, and III of bovine CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Subunits I, II and III of ubiquinol oxidase are homologous to the corresponding subunits in bovine CcO. Although not required for catalytic activity, subunit III appears to be involved in assembly of the multimer complex.	2.13402e-83
NC_016023.1\|WP_014096039.1\|717337_719083_-\|phospho-sugar-mutase	gnl\|CDD\|100092	cd05799, PGM2, This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. PGM2L1 is thought to catalyze the 1,3-bisphosphoglycerate-dependent synthesis of glucose 1,6-bisphosphate and other aldose-bisphosphates that serve as cofactors for several sugar phosphomutases and possibly also as regulators of glycolytic enzymes. PGM2 and PGM2L1 belong to the alpha-D-phosphohexomutase superfamily which includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Other members of this superfamily include phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.	0
NC_016023.1\|WP_014096045.1\|723708_724953_+\|extracellular-solute-binding-protein	gnl\|CDD\|270453	cd14750, PBP2_TMBP, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose; possesses type 2 periplasmic binding fold. This group represents the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.99018e-90
NC_016023.1\|WP_014096031.1\|706038_706965_+\|cytochrome-aa3-quinol-oxidase-subunit-II	gnl\|CDD\|273621	TIGR01432, AA3-600_quinol_oxidase_subunit_II, cytochrome aa3 quinol oxidase, subunit II. This enzyme catalyzes the oxidation of quinol with the concomitant reduction of molecular oxygen to water. This acts as the terminal electron acceptor in the respiratory chain. This subunit contains two transmembrane helices and a large external domain responsible for the binding and oxidation of quinol. QuoX is (presently) only found in gram positive bacteria of the Bacillus/Staphylococcus group. Like CyoA, the ubiquinol oxidase found in proteobacteria, the residues responsible for the ligation of Cu(a) and cytochrome c (found in the related cyt. c oxidases) are absent. Unlike CyoA, QoxA is in complex with a subunit I which contains cytochromes a similar to the cyt. c oxidases (as opposed to cytochromes b). [Energy metabolism, Electron transport].	1.41658e-98
NC_016023.1\|WP_014096032.1\|706989_708939_+\|cytochrome-aa3-quinol-oxidase-subunit-I	gnl\|CDD\|131928	TIGR02882, cytochrome_aa3_quinol_oxidase_subunit_I, cytochrome aa3 quinol oxidase, subunit I. This family (QoxB) encodes subunit I of the aa3-type quinone oxidase, one of several bacterial terminal oxidases. This complex couples oxidation of reduced quinones with the reduction of molecular oxygen to water and the pumping of protons to form a proton gradient utilized for ATP production. aa3-type oxidases contain two heme a cofactors as well as copper atoms in the active site. [Energy metabolism, Electron transport].	0
NC_016023.1\|WP_014096046.1\|725138_726353_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	1.80673e-88
NC_016023.1\|WP_014096035.1\|710002_710746_-\|SDR-family-oxidoreductase	gnl\|CDD\|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	1.02444e-81
NC_016023.1\|WP_041818213.1\|731014_732130_-\|methionine-biosynthesis-PLP-dependent-protein	gnl\|CDD\|181320	PRK08247, PRK08247, methionine biosynthesis PLP-dependent protein.	0
NC_016023.1\|WP_035200705.1\|711835_712321_-\|VanZ-family-protein	gnl\|CDD\|227939	COG5652, COG5652, Predicted integral membrane protein [Function unknown].	2.0962e-09
NC_016023.1\|WP_014096038.1\|712513_716935_-\|S8-family-serine-peptidase	gnl\|CDD\|173801	cd07475, Peptidases_S8_C5a_Peptidase, Peptidase S8 family domain in Streptococcal C5a peptidases. Streptococcal C5a peptidase (SCP), is a highly specific protease and adhesin/invasin. The subtilisin-like protease domain is located at the N-terminus and contains a protease-associated domain inserted into a loop. There are three fibronectin type III (Fn) domains at the C-terminus. SCP binds to integrins with the help of Arg-Gly-Asp motifs which are thought to stabilize conformational changes required for substrate binding. Peptidases S8 or Subtilases are a serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	3.82095e-84
NC_016023.1\|WP_014096044.1\|722846_723593_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|274977	TIGR04094, AraC_family_transcriptional_regulator, YSIRK-targeted surface antigen transcriptional regulator. Bacteria whose genomes encode only one protein with the YSIRK variant form of signal peptide (TIGR01168) were examined for conserved genes near that one tagged protein. This protein is found adjacent to at various classes of repetitive or low-complexity YSIRK proteins (whether unique in genome or not), in a range of species (Enterococcus faecalis X98, Ruminococcus torques, Coprobacillus sp. D7, Lysinibacillus fusiformis ZC1, Streptococcus equi subsp. equi 4047, etc). The affliated YSIRK proteins include Streptococcal protective antigen (see ) and proteins with the Rib/alpha/Esp surface antigen repeat (see TIGR02331). The last quarter of this protein has an AraC family helix-turn-helix (HTH)transcriptional regulator domain.	5.66765e-32
NC_016023.1\|WP_014096042.1\|721307_721622_-\|iron-sulfur-cluster-biosynthesis-family-protein	gnl\|CDD\|366687	pfam01521, Fe-S_biosyn, Iron-sulphur cluster biosynthesis. This family is involved in iron-sulphur cluster biosynthesis. Its members include proteins that are involved in nitrogen fixation such as the HesB and HesB-like proteins.	2.35476e-06

>NC_016023.1|WP_014096039.1|717337_719083_-|phospho-sugar-mutase
MSTDWKTSYEKWNRFAELDAALKAELAGVSGDEKNLEDRFYKNLEFGTGGMRGELGAGTNRMNIYTVRKASEGLANFILDQGEEAVNRGVAIAYDSRRKSPEFALETAKTLGKHGIKAYLFDSLHPTPLLSFAVRYLNAYAGVVITASHNPKEYNGYKVYGPDGGQMPPKEADELTGYVNRVENELLVEVGEEKDLIEKGLLVYIGENVDKAYQDQLIKLRQNKEVISSVADSFKIVYTPLHGTGNLPVRRGLENFGFQNVTVVKEQELPDSEFSTVKSPNPEEHAAFELAIRYGEEIGADILLGTDPDTDRLGVAVKNHEGKYEVLTGNQTGALLLHYLLTQKQKQGTLPENGIVIKTIVTSEIGRDIARSFGIPTIDTLTGFKFIGEKIKEFEKTGAHTFLFGYEESYGYLIGDFVRDKDAVQSAVLAAEVAAYYKSMGKTLYEGLLDIFEQYGYYKESLTSLTLKGKEGSEKIAGILANFRAHPLTEVAGIPVSAREDYQSQVRTNAKTGETSKIELPKSNVLKFFLEDGSWFCMRPSGTEPKVKFYFGVKADSLAESEQRNKRLSDEVMNLVNRMLE
>NC_016023.1|WP_014096038.1|712513_716935_-|S8-family-serine-peptidase
MKNAGTAKKLVFLLLTVVLIFSNGILLAPSKSQAAGKEKTNPLVKMPDRKKPDGLDQAEKYKEDRQVRVIIELAGSPAITYATKRGIRYKDLSKDKKTELQQQIKDQQSGVLSAIRSKKLPLKVENQFTTVANGISGTIPYGKIKELKKIENVSHVYIVNRYKRPQDKLQSVSSNGLTGAPETWNLKYKGQGMVIGVIDTGIDYRHKDMVLSEGTVPKLTQAKVSDLVKKDALSGKYFTAKVPYGYNYADKNTNIIDEGDGASMHGMHVSGIAAANGNESEGGVKGIAPEAQLLALKVYSNDQDQAYTYGDIYMKAIDDAIKLGADVLNMSFGTPDASTDGNDPEQKAVNRAVDNGIFMSVAAGNEGQIGGEEHSPFASNPDIGTVNAPGTAPNAMSVASMENTNVHADLLDYTVAGGKTASIPFFSAGSRHPNDVVNKTYDVVDCGYGTAEDFAGKDLSGKYALMARGGNTNLIEKTANAQSAGANGAIIYNNESGILEMASDRFIKIPQISVLQADGEAMKAALSEGKQVSLTFTGKKAEIQNPEAGKMSFFSSWGTASNLDFKPEITAPGGEIYSTLNNDQYGTMSGTSMATPHVAGGAALVLQYIQSAFPSLKGADKIKLAKTLLMNTAMPLTDPDSKTFYSPRKQGAGLMQIDRAVTTPVYIVRKGTSDGKVALKEISANKFSFTLTATNFGNRDAEYTVSTKPVADRVDAQGKLALSSAEIEGATVTIDNPSVNIPKGGSKDITITIDLSRADANLAKKMKNGYFVDGFVTFHEEGSGLPDLSVPYSGFKGDWGKAPVLDQMVYNWKQSFFQISGMVDGDGYYLGEDLFEENHFDQNKIAISPDEDGSGDTATPVLSFLRNSKMAEFSILDGNKKEIRKLYTEYDLPKNIWDDLPYTYLPDETTWDGTANNKKVADGKYYYQIRTTPGDSGKPGQTMQIPVLVDTKVPEISHISYDHDADEVSFSAMDNGGSGVQYILLFVDGNLEGAVEPDAGQTYHVPLSVKANQSITVTAYDYAGNHATKTVSGKNAVSGIHLEEPFALMPYDSRDIDVYGTITSPYKVRFVTVEGKDLAVSPVKIPVDEDVDGTYLFDSTMAGQPIRFKKDGVFDLKISAIDEKQNKMEFNRKVIIDSTEPEIKADGLPNDNRTEAGTVKVTVTDNFDRLRFTENGNEIFNHPFGKDVKSGDQFAMRKFSKTMTLKLADGKNVFKAEDFAGNITELAVIKIPPKPSHVDKVGDRDTKVTGSAKSGLVVEVKAGSKKLGSAAVKNGKFSVPIPKQKAGTVLSVSAKQTSTGYASRTVQVKVADETPPPPPKVRTVTNFSKKVTGTAEPYAKITVKAGKTTIGTGKADKNGKFAVKIQSQSIGKKLYVYATDAAHHPGKTTVVTVKPPAPSAQGVKAGATKVTGTALSGSKIYVKTGKTAIGHAVAGKNGKFIVKIKKQKAGTKLSLYAVKNGIWSDAKTITVQK
>NC_016023.1|WP_035200705.1|711835_712321_-|VanZ-family-protein
MKKKQSALVLAGICILFMAAMFLFSNQPYKEQDMRPELEKLVHLDANTLPKIEFYYGGALVTSTLPYDFIEFWIRKSCHVAEYAVCTLLILLTLRTVLVPVRFAVPAGFLASFFYANFDEWHQSFVSGRTGHFIDVITFDSFGILIGVCLFLWFTRRKRSR
>NC_016023.1|WP_014096036.1|710955_711768_-|teichoic-acids-export-ABC-transporter-ATP-binding-subunit-TagH
MSISVRFKNVSKKYKMYRSNSEKILDIILPGGYGDDFYALQNISFEASNGDVIGVVGVNGAGKSTLSNLITGIIPPTTGTIELNGETSLIAINSGLNNELSGLENIELKCLMLGFTKKQIKELTPQIIEFADIGQFIDQPVKKYSSGMKSRLGFAISVNVDPDILVIDEALSVGDQTFADKCFEKMNEFKDAGKTIFFISHSMGQVKKFCEKAMWLEAGEIKQYGAIDDVLPNYEKFLKEFKSWPKEKQKNFKQMILEKRSKERKEKVAE
>NC_016023.1|WP_014096035.1|710002_710746_-|SDR-family-oxidoreductase
MASLENKIAIVTGGASGIGIATAKAFTEKGAKVVISDYNEESGKAVEKELKEKGADVCFIRADASDEQSVADLVAETVNRYGKVDIMVNNAGIGVMAETHELSFEDYQKVISVNQNGVFFGSKYAIREMLKTGGGCIVNTSSILGYVGEPGAFAYNASKGAVNLMTKSLALEYASKGIRVNAVNPGYVETGMVNKEALGDFYDGLVARHPIGRLGRADEIAHAIVFLCENEFVTGIALLVDGGYTAQ
>NC_016023.1|WP_014096034.1|709543_709828_+|cytochrome-aa3-quinol-oxidase-subunit-IV
MEHHSKYPIGHIIGFLLSIVLTLVALYVALYTNLSKTAIIWTIGFFAFLQAGVQLFMFMHVKEGESGKINVGNMIYSIIIAIVVVYGTIWVMHF
>NC_016023.1|WP_014096033.1|708935_709544_+|cytochrome-aa3-quinol-oxidase-subunit-III
MSDEHLDTSLPLEYQRNQDRLTIFGFWVFLAAEITLFATLFATYFTLQHQTAGGPVQQDIFELKGVLIETFVLLTSSFTCGIAIFNMRNRNKGAMLGWFIVTLLLGLTFVGFEINEFVTYIHDGATLPTSAFLSAFYVLLGTHGCHVSLGILWGISIIIQLIRRGLTPMTARKFFVVSIYWHFLDVVWIFIFTFVYLGGLMK
>NC_016023.1|WP_014096032.1|706989_708939_+|cytochrome-aa3-quinol-oxidase-subunit-I
MKLSDFFVTGEPAIYAAEVGMALGAAAVIFSLTYFKKWKWLWKEWLTTVDHKKIGIMYIIVAVLMLFRGGVDALMMRTQLALPNQHLLDANHYDGIFTTHGVVMILFMAMPFLFGLINVAVPLQIGARDVAFPLLNAFSFWAMVAGMCLFNISFIIGGSPTAGWTNYFPLAGTEFTKGVGNNYYALGLQLSGIGTLATAVNFIVTILKMRAPGMTLMKMPMFVWSTLITFIIVLFAFPVLTVALAEVTFDRTFGAHFFTMGSGGSPMLWANLFWIWGHPEVYIVLLPSLGIYADIISTFSGKRLFGYASMVVAMAGIAFLSYFTWVHHFFTMGNTAVVNSFFSISTMIIAVPTGVKLFNEIFTMHKGKIRTTTPMLWSLAFIPTFLIGGVTGVMLSMAAADYQYHNSYFLIAHFHYTLIPAVAYACFAGLFYWYPKMFGYMLNEKLGKITFWLWMIGFNLCFIPQFFVGLDGMARRMYTYEAGLGWTGWNFASTVGAYFMGIGFLVLAWNIVYSIKHGVRDTTGDPWDGRTLDWATPTPVPEYNFAKQPVVSTLDAFAEYKENGTPIYRDEEYKPIHMPNNSAMPFFSAVSMGLAGFGLVWSWWWLAILGGLMMLGCLAWRSFDPDKGHYISVEEIIRTENTRAGGVKR
>NC_016023.1|WP_014096031.1|706038_706965_+|cytochrome-aa3-quinol-oxidase-subunit-II
MLRKLPWKLVLLLSLTSLFLLGGCDTKIAVLDPQGPMAREQYHLIVYSSILMAFVFVVVLGLYLYMVIKYRASRLPADYKPPQIHGHKVLETVWTAIPVLLIIAIAIPTVKANYSVEETPKSMKNEKPLTVYVTSSEWKWIFSYPEQGIETVNYVNIPAGRPINFELTSSGTMASFWIPELGGQKYTMPNMTMRLILAADHPGEYTGRNANFNGEGFAKMDFDVLAQTPKDFNAWVKEVKSRAPQMKKSDYEKLIKKEGLVGRQTYTGTHLKWDKPDEQKSYYEESEKGEKQNHHHHHDMSGMDMSGK
>NC_016023.1|WP_014096030.1|705032_705692_-|HAD-family-hydrolase
MIKAVIFDFDGLIMDTESEHYDVLCEIFRGYDCEMPLELWGKGIGTHSDFKPFKYLKEQIKKPLDTEKLDHKLEEMFLKRLETGAAREGVEDYLKSARQLGLKVGLASSSDRKWLHRYLRQLGLLAYFDCIKSSDDVEKVKPDPALYLKAAGCLGVEPEQCLVFEDSPNGSLAAKRAGMACVVVPNRVTKDLKFGEIDHRLGSMAETPLEEVIRFIESR
>NC_016023.1|WP_014096041.1|720304_721291_-|acryloyl-CoA-reductase
MKETFRALVMENASQPVLSVQEWDTGRLPDAEVTVKVAYSSVNYKDALVGVKGDFVKSYPFIPGIDLAGTVLASADSRFKEGDEVIVTSYKLGTGHFGGFSEMARVPAAWVVPLPKGLTLRESMILGTAGFTAALSVQKLEDHGLKPGQGPVLVAGASGGVGSVAVDILAKRGYEVTVSTGKKEAHAYLKRLGAARILDREAVTDHEDQSIRKKEWAAAVDPVGGKTTQYIISTLQYGGAVATSGLTGGREVTTTVTPFLGRAISWLGIDSVFCPMDLRVKIWEKLASDFKPEHLTSEIVREISLEQVPAALSDILEGKLQGRTIVKL
>NC_016023.1|WP_014096042.1|721307_721622_-|iron-sulfur-cluster-biosynthesis-family-protein
MEIDIKPAALSQFKQIEFQEGEGIRIEAVFVGSCTIAAEHSLKIDHKREDDDLFNVYGIPLLVSKASQKQLGEKVIIDYNPNKGYKLSSDQEVYQYNLDLTRAE
>NC_016023.1|WP_014096043.1|721798_722524_-|WecB/TagA/CpsF-family-glycosyltransferase
MKKAFGNIDLTVITEEQFLDEFESRVHEGIKTNVFFLNAHCYNIAQTDRDYYRIINEADYLLNDGVGIEIGAKLFDIPLAGNLNGTDLTPKILKRCEKNGFSVFVLGATETNLQSAIQHFRKDYPDLKIAGCHHGYFQSKHEIVAMINRSHADVLLVGMGVPLQEKFIAGFDQELSCTARLGVGAFIDFASGNVPRAPYLFRKLRIEWLFRLLREPKRLWKRNFGSLIFLCRILRYKWKHS
>NC_016023.1|WP_014096044.1|722846_723593_-|AraC-family-transcriptional-regulator
MKQSAISKSIIERYLSYRVEHQREYFLHPPYMMEKQLLNAVKEGRVEAAESVLKTINTLERAKLAEEPIRSLRNSLICICTLFTRAAIEAGVPPETAFNISDAHILEIERLKTQEKLFELEYSMLRNFTEAVQQARKQENRYSHAIHMAVAYIHENILQVITLESLAKHVYLNPSYLSHLFKKETGVSVTDYINKKRIEESIYFLLHTNITISEIALLFHFCNQSYYTSLFKKYMGLTPKEFREQNQH
>NC_016023.1|WP_014096045.1|723708_724953_+|extracellular-solute-binding-protein
MWKKAGVILAALTLVIGVLAGCGSNSSSKSSKSGSSSKKIVLKFAAQNDSTPATKAVIAAFNKQSKKYQVKWVQMTNDSAQMHDQLLTSLSSGSSEYDIMSMDVVWGGEFAGAGYLVPIDKKMMDANLAKDQFNAGSMASGNYEGKQYTLPFFPDLGILYYRSDIVSKEDAAKLESGDYTYKELGDMAAKYAGKNGTTNGFVYQSKQYEGLTVNVTEFTNHYKDIKGGLETMYQFTKASWAPKDLLNYMEQQTLDSFAQGKSVFARNWPYQYGTIKTGGEGVKVDIKNVGIAPLPNGGAVGGWLLGINKNSKHVEGAWEFVKFVAGKKGQKIMSTKGGYLPGYNDLLNDPDVQKQNKMLTMPGFQKALKTTIARPVSAKYSKVSDTIQIAAHKYLSTGQNLDDAVKTIQDATGE
>NC_016023.1|WP_014096046.1|725138_726353_+|sugar-ABC-transporter-permease
MKKNRLQAFLFILPALLFIGVFSLWPIFQSLRYTFFDYQLNNQQKSGLYMSPRYNFDLFDETQTYVRLFLTEDREKITDPADWQKVDKLVHRVANVAKQYKGRKGVQKISQADQKKLMGLYTDSSKLVKEINAKYNTQNGKNLSKIVKDFKSSFVPSNFIGFKSYKEALHDKRLGHALWNTVLFTVVSVFLEFVLGLGLAMIMNKAFRGQGIVRTTSLIPWAIPTAVAALMWSYLYDGTSGVVAHFFQSIGLISDSRILLLTGSGAMVSTILADVWKTTPYMALLLLAGLQNISKGLYEAASIDGATKIQQFFKITLPMLKPSILVALLFRTLDAFRVFDLIYVLTGGGPGGATETMSVYGYKTMFGQTNFGYGSVIVIIMFICVAIIATIYIKVLGANLMDKN
>NC_016023.1|WP_014096047.1|726365_727193_+|carbohydrate-ABC-transporter-permease
MKTNRKWNVLIIALIVVFLFGMIFPFFWIFITSFKPSGEIFGDGAFRVFAHHPTWENYTQIFQKGILTSVKNSFIVATTTTVYIILIATFTAYAISRFDFKGKNLLLGLILAVSMFPQMIVTGPIYNLFLHLHLTNSYAIVLPYSTITLPTAVWILVTHFNQIPLALEESAKIDGATPVQTLFRIVFPLAAPGVFTTAIITFIAAWNEFLLTITLNSDANYHTVPVAISFLRTQFEILWGQVAAATTVVTVPTLIIVLLFQKQIVSGLTTGGVKE
>NC_016023.1|WP_014096048.1|727402_729697_+|glycoside-hydrolase-family-65-protein
MTWEITKHELDKQMLLVNESLFALGNGYLGVRGNFEEGYPEEIPSIRGTYLNAFYDITEIQYGEKAYGFPETSQKMLNVIDAQTIEIFLGEEKERFSLFEGDVLGFSQTLHMKRGFSERAIHWKSPSGKEIKLTFSRLVSFTQRELFAIQVKMEPVNFSGPVRVISTVNGDVQNYVDKNDPRTGSAHAKRLAVTKAAAESGTIVLLARTFASGLETACAATHVVSASCECHYEQGEQKVRAIIDFKPGEPVSLTKFAIYTDTLRHGDHAAEKAADILKSMQDKDFSALLREQEQYLATYWQAADIEIDGDPKLQEGIRFNLYQLLQSVGKDTASNIAAKGLSGEGYEGHYFWDTEIYIFPVFLLTHPELARHLLLYRYHILDHARARAKEMGHQKGALFPWRTISGTECSPYFPAGTAQYHISADIAYSYMQYWYATQDQDFMKQYGIEILVETARLWLEVGHYREKDGKFAIEDVTGPDEYTSIVNNNYYTNVMAKYNLKSAHKFYYWLKETDAAFFAAFAARLGLTDEEAASWRKAADAMYLPYDEKRGIHKQDDSFLDKAVWDFEHTPKDHYPLLLHYHPLTIYRHQVCKQADTVLAHFLLEEEADPETVRNSYHYYEKVTTHDSSLSTCIFSIMASRLGETKKAYHYFIETARLDLDNTHGNTKDGLHMANMGGTWLSIVYGFGGIRIKENGLFLNPAIPEQWDRYLFRLTYQNRRLQVEVTRHAFKVALLEGDVLDIHIGGRTETLQPGRTVTRPIPGL
>NC_016023.1|WP_014096049.1|729842_731018_-|cystathionine-beta-lyase
MTNEDYSFQTRLLHNSHKIDPATGAVSVPIQHASTYHQADIDQFGKYDYSRSLNPTREALEDVIAELEGGVKGFAFASGMAAISTAFLLLSAGDHVVITEDVYGGTFRMVTEVLTRLGIEHTFVDMTNLEEVRQAVRPNTKAFYVETPSNPLLKVTDIRAVSELAKETGALTFVDNTFLTPALQRPLELGADIVLHSATKFLAGHSDVVAGLAVVKDEALAARLGFLQNSFGAVLGVQDAWLVLRGLKTLHVRLLQSQQSAVKIAHFFDAHPLVRNVYYPGLGHHPQHALQKLEAQGPGAVLSFELEDEEALRTFVSHVKIPVFAVSLGAVESILSYPAKMSHTAMPPEDRRKRGISDSLLRLSVGLENPDDLIADFEQAFSYTKAGTTVK
>NC_016023.1|WP_041818213.1|731014_732130_-|methionine-biosynthesis-PLP-dependent-protein
MYHTETKLAQIGNRSDRVTGAVNPPVYFSTAYRHEGIGQSTGFDYSRTGNPTRQLLEEAIADLEGGDRGFACSSGMAAIFTVLSLFQAGDEWIVSDDLYGGTYRLLEQGYKKWGLCCKYVNTCNPENIEQEITPKTKAIFLETPTNPLMQQTDIGAVAEIAKRHGILLIVDNTFYTPLLQQPIKEGADIVVHSATKYLGGHNDVLAGLIVAKGAELCEQLFLYHNGAGATLSPFDSWLLMRGMKTLALRMEKHEKNAKAVAAFLSAHPDVKDVLYPGRGGMLSFRVKEESWVDPFLRGLSLITFAESLGGTESFITYPATQTHADIPEEKRIASGVDNCLLRFSVGIEDERDLLADIEKAFANIHEGVQTR

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Crispr_ID: NC_016023_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016023_5

922253-922346

TypeV

Consensus_repeat	Method
ATATAAGTACTACCAAATATCCAAGTATC	CRISPRCasFinder

1 spacers

cas14j

The CRISPR arrays of NC_016023_5

>merge|NC_016023|5|922253-922346|CRISPRCasFinder
ATATAAGTACTACCAAATATCCAAGTATCGTTATGGCTCTCCAACCGTAAAGCGAAGTTAGAAATATATAAGTACTACCAAATATCCAAGTATC

>NC_016023|5|4|922253-922346|CRISPRCasFinder
ATATAAGTACTACCAAATATCCAAGTATC	GTTATGGCTCTCCAACCGTAAAGCGAAGTTAGAAAT
ATATAAGTACTACCAAATATCCAAGTATC

Protein	Signature genes	Signature genes Name	Protein_function
NC_016023.1\|WP_014096224.1\|925528_926875_-\|amino-acid-permease	unknown	unknown	gnl\|CDD\|129987
NC_016023.1\|WP_014096228.1\|932529_934254_+\|allophanate-hydrolase	unknown	unknown	gnl\|CDD\|236177
NC_016023.1\|WP_014096213.1\|912043_913162_-\|helix-turn-helix-domain-containing-protein	cas14j	-	gnl\|CDD\|223747
NC_016023.1\|WP_014096221.1\|924257_924890_+\|DUF4411-family-protein	unknown	unknown	gnl\|CDD\|350279
NC_016023.1\|WP_014096217.1\|919355_920855_-\|xylulokinase	unknown	unknown	gnl\|CDD\|198374
NC_016023.1\|WP_014096208.1\|905227_906010_+\|DUF2268-domain-containing-protein	unknown	unknown	gnl\|CDD\|370782
NC_016023.1\|WP_014096220.1\|922581_923940_+\|transposase	unknown	unknown	gnl\|CDD\|376573
NC_016023.1\|WP_003352379.1\|913249_913390_+\|ribbon-helix-helix-protein,-CopG-family	unknown	unknown	unknown
NC_016023.1\|WP_014096231.1\|935891_937700_-\|DEAD/DEAH-box-helicase-family-protein	unknown	unknown	gnl\|CDD\|368155
NC_016023.1\|WP_014096216.1\|915177_919014_-\|peptidase-M30,-hyicolysin	unknown	unknown	gnl\|CDD\|375438
NC_016023.1\|WP_014096219.1\|921322_921934_-\|hypothetical-protein	unknown	unknown	unknown
NC_016023.1\|WP_014096215.1\|913789_914929_-\|glutathione-dependent-formaldehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|176243
NC_016023.1\|WP_014096227.1\|928930_932533_+\|urea-carboxylase	unknown	unknown	gnl\|CDD\|274264
NC_016023.1\|WP_041817928.1\|934715_935336_-\|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|234675
NC_016023.1\|WP_014096211.1\|907961_911099_+\|SH3-domain-containing-protein	unknown	unknown	gnl\|CDD\|226656
NC_016023.1\|WP_014096223.1\|925296_925518_-\|hypothetical-protein	unknown	unknown	unknown
NC_016023.1\|WP_014096209.1\|906140_906398_+\|hypothetical-protein	unknown	unknown	unknown
NC_016023.1\|WP_014096210.1\|906552_906696_+\|YjcZ-family-sporulation-protein	unknown	unknown	unknown
NC_016023.1\|WP_014096225.1\|927422_928145_+\|urea-carboxylase-associated-family-protein	unknown	unknown	gnl\|CDD\|163257
NC_016023.1\|WP_014096226.1\|928240_928894_+\|DUF1989-domain-containing-protein	unknown	unknown	gnl\|CDD\|132465

Protein	Function_ID	Function_description	E-value
NC_016023.1\|WP_014096224.1\|925528_926875_-\|amino-acid-permease	gnl\|CDD\|129987	TIGR00909, putative_amino_acid_transporter, amino acid transporter. [Transport and binding proteins, Amino acids, peptides and amines].	1.22491e-43
NC_016023.1\|WP_014096213.1\|912043_913162_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	8.74434e-55
NC_016023.1\|WP_014096221.1\|924257_924890_+\|DUF4411-family-protein	gnl\|CDD\|350279	cd18712, PIN_VapC-like_DUF411, CapC-like PIN (DUF411) domain in DUF411 domain-containing proteins and related proteins. This subfamily includes the DUF411 PIN domain in proteins annotated as DUF411 domain-containing proteins. It is an uncharacterized subfamily of the VapC (virulence-associated protein C)-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include FitB toxin of the FitAB TA system, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	1.16928e-80
NC_016023.1\|WP_014096217.1\|919355_920855_-\|xylulokinase	gnl\|CDD\|198374	cd07808, FGGY_D-XK_EcXK-like, Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases. This subgroup is predominantly composed of bacterial D-xylulose kinases (XK, also known as xylulokinase; EC 2.7.1.17), which catalyze the rate-limiting step in the ATP-dependent phosphorylation of D-xylulose to produce D-xylulose 5-phosphate (X5P) and ADP. D-xylulose has been used as a source of carbon and energy by a variety of microorganisms. Some uncharacterized sequences are also included in this subgroup. The prototypical member of this CD is Escherichia coli xylulokinase (EcXK), which exists as a dimer. Each monomer consists of two large domains separated by an open cleft that forms an active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. The presence of Mg2+ or Mn2+ is required for catalytic activity. Members of this subgroup belong to the FGGY family of carbohydrate kinases.	0
NC_016023.1\|WP_014096208.1\|905227_906010_+\|DUF2268-domain-containing-protein	gnl\|CDD\|370782	pfam10026, DUF2268, Predicted Zn-dependent protease (DUF2268). This domain, found in various hypothetical bacterial proteins, as well as predicted zinc dependent proteases, has no known function.	5.77925e-58
NC_016023.1\|WP_014096220.1\|922581_923940_+\|transposase	gnl\|CDD\|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	4.76481e-06
NC_016023.1\|WP_014096231.1\|935891_937700_-\|DEAD/DEAH-box-helicase-family-protein	gnl\|CDD\|368155	pfam04851, ResIII, Type III restriction enzyme, res subunit.	2.23545e-24
NC_016023.1\|WP_014096216.1\|915177_919014_-\|peptidase-M30,-hyicolysin	gnl\|CDD\|375438	pfam17936, Big_6, Bacterial Ig domain. This domain is found in a wide variety of extracellular bacterial proteins often in multiple tandem copies.	1.03936e-20
NC_016023.1\|WP_014096215.1\|913789_914929_-\|glutathione-dependent-formaldehyde-dehydrogenase	gnl\|CDD\|176243	cd08283, FDH_like_1, Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1. Members identified as glutathione-dependent formaldehyde dehydrogenase(FDH), a member of the zinc-dependent/medium chain alcohol dehydrogenase family. FDH converts formaldehyde and NAD(P) to formate and NAD(P)H. The initial step in this process the spontaneous formation of a S-(hydroxymethyl)glutathione adduct from formaldehyde and glutathione, followed by FDH-mediated oxidation (and detoxification) of the adduct to S-formylglutathione. MDH family uses NAD(H) as a cofactor in the interconversion of alcohols and aldehydes, or ketones. Like many zinc-dependent alcohol dehydrogenases (ADH) of the medium chain alcohol dehydrogenase/reductase family (MDR), these FDHs form dimers, with 4 zinc ions per dimer. The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit.	0
NC_016023.1\|WP_014096227.1\|928930_932533_+\|urea-carboxylase	gnl\|CDD\|274264	TIGR02712, Includes:_Allophanate_hydrolase, urea carboxylase. Members of this family are ATP-dependent urea carboxylase, including characterized members from Oleomonas sagaranensis (alpha class Proteobacterium) and yeasts such as Saccharomyces cerevisiae. The allophanate hydrolase domain of the yeast enzyme is not included in this model and is represented by an adjacent gene in Oleomonas sagaranensis. The fusion of urea carboxylase and allophanate hydrolase is designated urea amidolyase. The enzyme from Oleomonas sagaranensis was shown to be highly active on acetamide and formamide as well as urea. [Central intermediary metabolism, Nitrogen metabolism].	0
NC_016023.1\|WP_041817928.1\|934715_935336_-\|NAD(P)H-dependent-oxidoreductase	gnl\|CDD\|234675	PRK00170, PRK00170, azoreductase; Reviewed.	3.07232e-74
NC_016023.1\|WP_014096211.1\|907961_911099_+\|SH3-domain-containing-protein	gnl\|CDD\|226656	COG4193, LytD, Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism].	8.56896e-71
NC_016023.1\|WP_014096228.1\|932529_934254_+\|allophanate-hydrolase	gnl\|CDD\|236177	PRK08186, PRK08186, allophanate hydrolase; Provisional.	0
NC_016023.1\|WP_014096225.1\|927422_928145_+\|urea-carboxylase-associated-family-protein	gnl\|CDD\|163257	TIGR03425, urea_degr_2, urea carboxylase-associated protein 2. A number of bacteria degrade urea as a nitrogen source by the urea carboxylase/allophanate hydrolase pathway, which uses biotin and consumes ATP, rather than my means of the nickel-dependent enzyme urease. This model represents one of a pair of homologous, tandem uncharacterized genes found together with the urea carboxylase and allophanate hydrolase genes.	1.21603e-106
NC_016023.1\|WP_014096226.1\|928240_928894_+\|DUF1989-domain-containing-protein	gnl\|CDD\|132465	TIGR03424, urea_degr_1, urea carboxylase-associated protein 1. A number of bacteria degrade urea as a nitrogen source by the urea carboxylase/allophanate hydrolase pathway, which uses biotin and consumes ATP, rather than my means of the nickel-dependent enzyme urease. This model represents one of a pair of homologous, tandem uncharacterized genes found together with the urea carboxylase and allophanate hydrolase genes.	2.15652e-120

>NC_016023.1|WP_014096219.1|921322_921934_-|hypothetical-protein
MDSNTRQSGQKNKNKKLVILVSGFVLIIAAVFALVIYNSIQQEKAKRIAADKKYVHAMHQFVSDGYKAGTKAEEMVKTLQDVWHDAIFEATYEIDGKIHASGMDFNDAIQAQYTSFEKNGDLSKLESHQAALEADMDKLKNPPAKYKDIYHDIVDAYGSLKEFTEMADDPSGSLDSFTDKANELDSEVAKKLNAVDVQLPEEK
>NC_016023.1|WP_014096217.1|919355_920855_-|xylulokinase
MKYAIGVDLGTSSVKVLLVDQNGQVVSSVSKSYPLMQPHPGYSEQDPEQWVEKTIQALKELTEKSGVPRDEIEGLSFSGQMHGLVLLDENLQVIRNAILWNDTRTTEQCKKIDQVLGGKLLEITKNPALEGFTLPKILWVQQYEPENFRKTRVFLLPKDYLRYRLTGTIGMDYSDAAGTLLLDIVNQSWSTDILRTFDIPADICPPLVETEAEVGTLLPDIAATCGLSPATKVFAGGADNACGAIGAGILEEGKALCSIGTSGVFLSYESDSNKNFGGKVHLFNHGQKDAYYTMGVTLAAGYSLSWFKDTFTKGEDFATLLEEAAHSSIGANGLLFTPFIAGERTPYADAKIRGTFTGIDSSHTRRDFTRAVMEGIVFSINESVEIFRNYGKNIDTVISIGGGAKSDLWLQIQADIFQAKVIKLQNEQGPGMGAAMIAASGLGWFSSLKDCAAAFIRTGRTFEPIPKNVSRYRDFYQVYKDVYPHTVAINHQLFDLREE
>NC_016023.1|WP_014096216.1|915177_919014_-|peptidase-M30,-hyicolysin
MKKVRFVLYVLLAFSLIVGLPIGAQASSGDTNYYELISNEFPDGSNSEYTGSFRINNDAYAESKKLSPSAYRMDYVAPFDTEKNQNKALKKETKSIKKDYVKGDSKSFYVQNIETSDFSSISATLLYSGDHANVWVNNNDITEDEAALLGKEFDNKIYQSDVDNFGTPSDVDQNGKVNILCYDIQDGFSGSGGYVAGYFSPRDLYYYSYSNQSEIFYIDTYPLMGMSATKDVSQAYSTLAHEFQHMINFNQKVFVQGLTDTETWMDEGLSMAAEQIYTGAPLNDRIDYYNEDADITKGHSLLYWDYEGDTLANYSLSYLFMEYLKAQCGQGNTIYKELINDPHTDYQAVQNIIHKYIDPNLSFGQFMTDFRAALVLKENTGLYGFKGDTAFDGLKVKTYSGSSINIKGGGAIVKALSSKDDFQVPSDKGTDITYTLLEKGDAGAVTSLSKPSVQTVGDNDTVVTGTADPNVTVKVAVSGKEIGSNSTDSNGSFSVSIPKQKAGTELHVHTEDGKGNQSEETVVTVQDKTAPAAPKVNEVSDASTAVKGTTEAGAKVTVKSGSNILGTATADSTGAFKATIAKQKVGTKLVVYAEDAAGNKSAETTVTVIDKTAPAAPKVGEVSDTSTTVTGTTEAGAKVTVKSGLNILGTATADSTGAFKVTIAKQKAGTKLVVYAEDAAGNKSAETTVTVIDKTAPAAPKVNEVSDTSTTVTGTTEAGAKVTVKSGSNVLGTAKADNTGAFKVSIAKQKAGTKLVVYAEDAAGHKSGETTVTVIDKTAPAAPTVQPFGDNQTVITGKAEAGSTVTIKSGKTILGTATASSKGSFSVRIKSKQKAGTVLTAYATDKAGNTSAGKSFKVEDKTAPSAPSVNRFGDNQTMITGKAEAGAKVTIKRGKTVLGTGTASSKGSFSVRIKSKQKAGTVLTAYATDKAGNTGAGKSFKVEDKTAPSAPSVNRFGDNQTTITGKAEAGAKVTIKRGKTVLGTGTANSKGTFSIRIKSKQKAGTTLTAYATDKAGNTGAGKSFKVVDKTAPSAPSVNRFGDNQTTITGKAEAGAKVTIKRGKTVLGTGTASSKGSFSVRIKSKQKAGTVLTAYATDKAGNTGAGKSFKVEDKTAPSAPSINRFGDNQTTITGKAEAGAKVTIKRGKTVLGTGTANSKGTFSIRIKSKQKAGTTLTAYATDKSRNTSAGKSFKVADKTAPGVPTAGKVTYKSTKVSGKAEKYATVYVYNGSHYVGKATANSRGTYSVHMKKQKRGSTLKIYAKDKAGNKSKYRYVKVK
>NC_016023.1|WP_014096215.1|913789_914929_-|glutathione-dependent-formaldehyde-dehydrogenase
MKAVTFQGAKDIQVKEVDDPSLKKRDDILVRITSTAICGSDLHIYNGALPARPGFVIGHEPMGIVEEVGSEVTKVKKGDRVVLPFTVSCGHCYYCQHGMESQCDNSNPNEEVDTGGLFGYTERYGDIPGGQAEYLRVPFGNQMPFVIPESCELEDEALLFLSDVLPTAYWSVENAGVKQGDTVVVLGCGPIGLMTQKFAWLNGASRVIAVDHVPYRLKHAKKMNRVEVYNFKEYDEMGKYLREITNGGADVVIDCVGMDGKKSAIEKIEQKLKLQGGTISAIQIAMEAVRKFGTIQLTGVYGSVYNAFPLGRLFERNITLKMGQAPAKHLMPKLFQDITEKKFDPTEIITHKISLDKASEAYQLFSDHKDGCIKVVLKP
>NC_016023.1|WP_003352379.1|913249_913390_+|ribbon-helix-helix-protein,-CopG-family
MREEKERVEIRMPKTILEKLEQYQKENGIPTRTAAILELLRKGLEK
>NC_016023.1|WP_014096213.1|912043_913162_-|helix-turn-helix-domain-containing-protein
MAKQNKAFKFRLLPNKEQSALLAKTFGCVRFVYNKMLAERKETYEKFKDDKELLKKQKFPTPAKYKSEFPFLKEVDSLALANAQMNLQTAYKNFFEGNADFPKFKNRKAKQSYTTNMVNGNIKLENGHIKLPKIKKPIKMKQHREIPADYKIKSCTISKTKTGKYYISILTEYEKDIRPVNIQKVVGLDFAMDGLYVESEQGKKANYPRYYRQALDKLAKAQRILSRRKKGSARWNKQRLVVAKLHEKVANQRMNFLHHKSKELASNFDAVVIEDLNMKGMSQALHFGKSVHDNGWGMFTTFLAYKLKEQGKQLVKIDKWFPSTKKCSCCGKEKEMPLSERVYKCSCGFVLDRDHNSAINIKNEGLRLLALS
>NC_016023.1|WP_014096211.1|907961_911099_+|SH3-domain-containing-protein
MKKGLVIPLCFAVLSTPAFDKTVQGASLTKFLHSSSVQAAAKTETKYVNVDANSSLTLRAKPSKSAAKLDSLKKGTAVLVYNVSDGWAEVKSGTKTGYVSAEYLTSTKPGSTATTTSTTKTTTKYVNVDKGSHLILRSKTSTSSSILASLARGEKVTVYSISGDWAKVKAGSKTGYVHASFLVNSNPDSNTSTSKPAKTTTKYVNVDKGSHLILRSKASTSSSILASLARGEKVTVYSISGDWAKVKAGSKTGYVHASFLANSNPDSSADTSTPAKTTTKYVNVDKGSHLILRSKASGTASILDSLARGEKVTVYSISGDWAKVKAGSKTGYVHASFLANSNPDSSADTSTPAKTTTKYVNVDKGSHLILRSKASTSSSILASLARGEKVTVYSISGEWAKVKAGSKTGYVHASFLANSNPDSNADTSTPAKTTTKYVNVDKGSHLILRSKSSTSSSILASLPRGEKVTVYSISGAWAKVKAGSKTGYVHASFLANSNPDNHADTSTPAKTTTKYVNVDKGSHLILRSKASTSSSILASLARGEKVTVYSISGDWAKVKAGSKTGYVHASFLANSNPDNHAGTSTPAKTTTKYVNVDKGSHLLLRSKASTSGKKLASLQRGEKVTVYTASGPWVKVKARGITGYVLASYLSSSDPDASTADDGNNSSEPTPDSTVTKYTTADLNLRKGPSTLTSVIEVLDKGTAVKVYSEEDGWAKVEIGGKIGYVSTNYLTSAAKQSNGKVTSIVKKYDLSLDELANIQMKVSPQTDTNERYIRSDAIKLTSHTTGVVQNGNWHIRDGAGTKNHEVGETLKEGTKVTILSTVKGNDGYTWYQISYNKAWKNATKNEVKYYLNPNNFVSDPVRSLQFLKLTSTANLNATEVNQKILAGKGILAEKASAFLKAAKQNGINEIYLIAHALLETGNGTSQLANGVKYNGKTVYNMYGTGANDGNAVQNGARYAYQHGWTTPEAAIIGGAKFISSNYLGAGQDTLYKMRWNPDVAATYGYASHQYATDIGWAYKQVDKIYNLYNLLDNYNITLEVPSYK
>NC_016023.1|WP_014096210.1|906552_906696_+|YjcZ-family-sporulation-protein
MSDGGVYSGGFALVVVLFILLIIIGASYVGGYGGGYGGYGGYGGCFW
>NC_016023.1|WP_014096209.1|906140_906398_+|hypothetical-protein
MSYRHFHALCHRYRGRAVQIRTVDGRIHRGIIHHVSGNRVFLRPLGGPRNLGGFGYGGWGWGWGFGWGIAIGSIAALALIPFFFW
>NC_016023.1|WP_014096208.1|905227_906010_+|DUF2268-domain-containing-protein
MGVVETDKWLRQLYHQPVAICEKFKAHFKGASAAEIYDYLAYHGMYQPEDNGAGIVRQLQNRHVWEIVKNEFLCCKKEWNGPDVPIYIFPSDSANLLIQKEFNGKSGLAFKDQLFLFVSARNSETEIRSLFVHEYNHVCRLTKYPKEEADYVLLDTIILEGLAENAVREKFGRKYVSSWAFSYSNDEMEKIWRQYVYPHRNLKKTKQQHQEILYGSRVYPKMSGYCVGYYLVKQYLEKTGLSVKDVLKTDAKVLAQIDSM
>NC_016023.1|WP_014096220.1|922581_923940_+|transposase
MCFPWEIFKPVERDYYTLLYLHLKNGRADDHSDEIQPALFSIPEEEEKFASSLFRPSPAGRKPHPFMPFFRAFELASLQYIEVMVESVYLQVKSNPLFATMCGFTEKIPSYRSFARFDQIMTTNGLWEKARLLVVEYNKGEGVVETDEEAAAVDTSHIEAEAALNKTRKTCSCEGYCDCPRVLTDDNVGVMRKSNAVSYIAHKLSMVCGVKSGLPLTREVFKGNTPDGKTLEPTLETFKAEHPEMAEQLSFILADGIYQTPENQKVTKDVLQAKLVASINPRNRKDKPTTARGIEKINRYGTPICISGHKMELRGSDREKGQYIYTCPVFHPNAKQEGLTCPLANHAECCNGAAQGRVFRIDFDQTPQVDVELPQHGRTFEVLYSARTIIERIFGILKDGYSLRRVHKRGKQAVEAHVDRCMISMHIMANMAYHQTGKANCGWTRNRLQRAN
>NC_016023.1|WP_014096221.1|924257_924890_+|DUF4411-family-protein
MAERKSGEMKQYTIDTNVLRYKANSKAEPSHKKAAKLFWKQVIQEIQDGEAIIGVPQEVIRELKFQSSTLSPKENEHISDLLEPCQEVLPDLANINIEHKIREMSAYVRSEFTTVVDERKMEYPAVADSRILHAAYYSDSVLVTSNIKEFLLYPLLFDDWNRLYDLLNKEYVNIPTELYQEIHKDPFFKSLLSDFHGLNQAIEDNEQPDT
>NC_016023.1|WP_014096223.1|925296_925518_-|hypothetical-protein
MPSLETGDTTTFGTVTAEANPAVAIKRGNTTIGTGEIGKKVSFRIKISKQKAVTTLTDYATDKAALGIPTLAR
>NC_016023.1|WP_014096224.1|925528_926875_-|amino-acid-permease
MENQPTLKRSLTLFQVVFLGLAWMTPMIFFTSFGISYESSKGMLTVAYLLAFLAIFFTASSYGKMAKAFPVSGSALTYITKVMNPFIGFLVGWVILLDYLFSCIIANLMFGINLHAQFPSVPSYIWIILLDIVLMVINIIGIKTSANISKLFVCIQIAFIALFCILVFHNLLQNDTSVHLAGPFAMGDSITFSTILAGASIICFSFLGFDSITAMAEETINPKKNIPRAIMIIISVAGILYFSTSYFLQLAYPELKFSNPDTAGFYVANLVGGKILGSIFTTVLVFAVFTQGLSSVATVTRLLYVMGRSAQLPKKSFGYLHPKFRTPVFNVVLVSVISLLGLFISLDTCIKFVNFGALTAFMFVNLSVILHYFIKEKRRTLKGIIAYLVSPLIGAGFIFYLLTLLDKDSLLMGLSWLALGLMYSLYLVARKKKRALVKEQENVTVTVE
>NC_016023.1|WP_014096225.1|927422_928145_+|urea-carboxylase-associated-family-protein
MDKIWNLTLNSGGKWSGVIGAGKQIRFTALEDGANLSMLLYHARNIAERYNMPDTLKAQHTNHLTKGNVLMSDNGRVLASIIEDDLGWHDTISGYTTRAQTNAKYGVTRYQNIRNDWLRCGEENFTMELVRSGLQKRDLVPNVNLFSKVTCDKSGQMHFHEDHCQKGASVTLRTDMDILLILSNTPHPLDPKTDYPSVPVRMEVLPGAPVTDNDICVTHCPENLRAFENTWEYQLLALPN
>NC_016023.1|WP_014096226.1|928240_928894_+|DUF1989-domain-containing-protein
MAVFQEIESPRKAEKAIYNKVIPAGEGWMHELLPGQVLRIVDLEGNQAVDTLFFDAENPEDHYSATATITAQQNIYLTTGTALLSESGKTLLKIVADTCGRHDTLGGACSAQSNTVRYSHDVLPMHNCRDTFMNLLANYGDTRYEKRDLAPNINFFMNVPVSPDGNLEFADGVSAPGRYVEMEALCKTVVLISNCPQLNNPCNAFNPTPIQLLIWDK
>NC_016023.1|WP_014096227.1|928930_932533_+|urea-carboxylase
MFKKVLIANRGAIATRIERTLSKMGIQSVAVYTKADQDSLHVDQADEAVLIGEGPAAESYLNADLIIKTAIETGAEAIHPGYGFLSENSDFARACRKNGITFIGPEPEQMEVFALKHTARNMARKAGVPLLPGTDLITTLEDAVEQAAQIGYPVILKSTAGGGGIGMRICDDEAALRKSFKAVRHLASSNFKNDGVYLEKYIAKARHVEVQIFGNRFGEVTALGERDCSLQRRNQKVIEESPAPNLPQHVRAAMLVSAKKLAATVNYRSAGTVEFLYDPDTLSFFFLEVNTRLQVEHGVTEEVLGIDLVEWMVKEAADELKYLDTLFGKPKGHSIQARIYAEDCYHDFRPGAGRIDKAVFSEKARVETWLRDGLTVTTLYDPMLAKIIVHGKDRQEAIKKLKTALKASKCYGITTNLSYLHALMNKSEWQRGEVYTRLLNTFHPAEHAIEVLDGGVQTTVQDYPGRKGYWDVGVPPCGPMDPLSFRIGNHLLGNEENAAGLEMTLRGGSYVFRHDTWFCLTGADMQATLDGVPVPMYEPVLAEKGRVLKFGEAQKGMRTYLLIAGGLEMPEVLGSSSTFTLGGFGGHGGRALRPGDVLGIRETDNRLKEHWISARLPEMTNEWIIGVIPGPHCTEEFLAQEYLEQLVETPWEVHFNSSRTGVRLIGPAPKWSREDGGEAGLHPSNIHDTPYAVGALDLTGDMPILLGPDGPSLGGFVCPVTTATAELWKIGQLHPGDIVHFQLLTLEEAEALWKKQDQTLQAVPLPEKTSNLSADYPVLVRETENRDFSFIIRCCGDSNLLVEYGEMELDLSLRFQIHVLMQAIKESGDIPVLDLTPGIRSLQVHINPDKMNVKTAAQRIVEIDKNLPDIASIEVPSRIVNLPLSWNDPATQLATERYQKNVRPDAPWCPSNLEFIRRINGLQRIEEVKEIVFGANYLVLGLGDVYLGAPVAIPTDPRHRLVTTKYNPARTWTPENAVGIGGAYMCVYGMEGPGGYQFVGRTVQMWNKLRTTDSFKPGKPWLLDFFDQIRFYPVEADELLQLREDFLRGRFHPKIEETTFHLGKYMAFLSKHQDSIQHFQQKQQAAFKKEMEMWKERGLDAFISEHHDTGQLAEEVFPEGVVPVRCTMPGSIWQVLVKSGQKIDKGETLLIEESMKMEFPQVAPCAGTIVSVKVEPGDEVHAGQVIVSILEEKEAEVPVQ
>NC_016023.1|WP_014096228.1|932529_934254_+|allophanate-hydrolase
MIPLTVEKLRLQYREEKTTPEAVIKEILNCVEADRGMNIWITPPTMEHIRPYLDRLASLDPEDAPLWGIPFAIKDNIDVAGMPTTAGCPDYTYVPEEHATVVKRLIEAGAIPLGKTNLDQFATGLVGTRSPYGETKNALREELISGGSSSGSAVAVARGHAAFSLGTDTAGSGRVPAALNGLVGFKSSLGAWPKKGVVPACASLDCVTVFTHTIEDALQVDHIIRGEDPLDPWSEDIPLRTPAKPLKILIPDSLEFFGPFAMQYEAEWKKTAERIKDLQIPVESIDIRQFAKASAILYDGPFVAERWSDLGGFIESHPGAAFSVTEKILKSGADPKYTAASVFRAIHKLQTIKKSVHQLLGDAVLVMPTTGGTWTREEVRTNPVQTNSKMGLYTNHCNLLDMCAIAVPAGEADTHLPFGITIFAKSENDHLLFGAASTFVAATNQTPIAVCGLHMRGFPLEKELVSMGGRFVKKAFTAPVYQLFKLPFETPKPGLVKNPDEGAAIEVELWEMPADAFGTFTASIPAPLGIGKVELADGSEVPGFLCEAYAAKSAEDITSFRGWRNYQHQIKTLI
>NC_016023.1|WP_041817928.1|934715_935336_-|NAD(P)H-dependent-oxidoreductase
MPKVLVVKAHPFSEEYSRTMKVTNAFLKSYREHHPDDDIEEMNLYDMTIPEIDRDLLEAWSKLKQKIPFYSLSNEQQHKVTLFDSFTASFMEKDKVVIANPLWNLSVPTRLKAWIDTITVAGKTFKYTDQGSVGLLEGKKALHIQSSGSVYNGSDPASQYVKMLFTFLGFKDYHQLFVEGMDHYPERATEIMEEAIKKAVEMGKTF
>NC_016023.1|WP_014096231.1|935891_937700_-|DEAD/DEAH-box-helicase-family-protein
MPSIFETREPYISENINLRIPQREAFQSIKVYYSRSENERETAIILPVGCGKSGLITITPFALKSKRTLVIAPGLNIASQLFKDFDPSQEELFYSKCHVLNTPPYPEPAEIRGKTTNLSDLEEAEVVITNIQQLQGVNNRWLSSLPADFFDLILVDEAHHNVAESWNIIRRAFPNANIVNYSATPRRADGQIMSGQVIYTFPIFRAIEEGYVKRLKAIVLNPRTLKYVRRQDGQEIEVSLDEVKRLGETDSDFRRSIVTSQETLFTIVDSSIRALNQIREESGNSNHKIIASALNRQHCIQVMEAYRARGLRAAYVHSLQDDADNDRVLSQLKNHQLDVIVQVRKLGEGFDHPYLSVAAIFSVFNELSPFVQFVGRVMRTVDQNSPDSLNNQGTVVFHAGSNIARLWEDFQEFSQADREFFDQLLPMEDFDFSKSDEIIIEPTSTNTSRNRRTNQVEIREQEGVSIIEIPLVLEDDEVKKALELLKSKGVTLEDIQISYKHHPIPTTKQRERQAARRALDETVRNNVSFILRQQGMNPQGHDLDRRRLGRSNFVILKAAVDKKINDFVGKDSGKRDEFSKNELDTIREKLNYIINEALQEVL

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Crispr_ID: NC_016023_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016023_6

1096065-1097943

Orphan

Consensus_repeat	Method
GTTTCAATTCCTCATAGGTAAAATACTAAC	CRISPRCasFinder
GTTTCAATTCCTCATAGGTAAAATACTAAC	CRT
GTTTCAATTCCTCATAGGTAAAATACTAAC	PILER-CR

28 spacers

The CRISPR arrays of NC_016023_6

>merge|NC_016023|6|1096065-1097943|CRISPRCasFinder,CRT,PILER-CR
TTTTCAATTCCTCATAGGTAAAATACTAACTTCGGCGGCGGCAATTTGTGCCTCCCTCTTTGTCTGTTTCAATTCCTCATAGGTAAAATACTAACGGTATTTTCCAACGTGTTTACTGACTGGAATACTGCGTTTCAATTCCTCATAGGTAAAATACTAACATCCACAGCTAACCAGGATTTGGTTTAGCAAAGCGATGTTTCAATTCCTCATAGGTAAAATACTAACTTCGGTTTATATCGTATCAACTCTAGTTTTACAGTCGCGTTTCAATTCCTCATAGGTAAAATACTAACAAAAATATCGCGTCCAGCTAGTAGACTCAAACGAAGTTTCAATTCCTCATAGGTAAAATACTAACACGGCAAAAACAACGCCTTACTATGTCACAGCGAGGTTTCAATTCCTCATAGGTAAAATACTAACATACTCGAGGAAAGGCCTAGCAATTTATACGCGGTGTTTCAATTCCTCATAGGTAAAATACTAACGTGCAGGCGGATATGCCTTACTCCAGCTTTTTTAAGTTTCAATTCCTCATAGGTAAAATACTAACTTGCTTTTTGATTATCTCCAGTTTTTGCATTTTCGGTTTCAATTCCTCATAGGTAAAATACTAACGGGCGCCTTACAAAATAGCATGAAAGGCGTAGGGGAGTTTCAATTCCTCATAGGTAAAATACTAACCGGCGAGATCGGCGTGATTGTCGATAATATATCGGAGTTTCAATTCCTCATAGGTAAAATACTAACGCCCAGCAGCGCACGAAAGCGCTCGGCCTGCTTCAGTTTCAATTCCTCATAGGTAAAATACTAACTTAGCTTTGGGTCTCTCAACAACGCAATTAAAAATGTTTCAATTCCTCATAGGTAAAATACTAACAACGAGCAATTAGCATTGGATCTTTTTTAGAAGCCTTGTTTCAATTCCTCATAGGTAAAATACTAACGCACGCCACGGAAAAACAGGCCATGGCGGAAATGCGTTTCAATTCCTCATAGGTAAAATACTAACATACTCGAGGAAAGGCCTAGCAATTTATACGCGGTGTTTCAATTCCTCATAGGTAAAATACTAACGGTACAGCACAAAAAAATTAATAACTGGTCATTTTTGTTTCAATTCCTCATAGGTAAAATACTAACACAAATGCAGTTTGACTGGTACGTGGCTACCACTCCTGTTTCAATTCCTCATAGGTAAAATACTAACTTTATACCGTTTTACAACTAAATGTACAGTATCTGGGGTTTCAATTCCTCATAGGTAAAATACTAACGGCGAGGAGGCAAAGGATCTGATCGCGGCCGGATATGTTTCAATTCCTCATAGGTAAAATACTAACGCAAACGGTAATTTGCCCATACTGTGGCAAAAAAAGGTTTCAATTCCTCATAGGTAAAATACTAACGGTGCACATTTTTGATTTGGTATAAAAAGCTATAGGTAGTTTCAATTCCTCATAGGTAAAATACTAACCTAAAACGATATTTCACGGAAGTCGACGAGGACAAGCGGTTTCAATTCCTCATAGGTAAAATACTAACCGCCAGATTGCGCCACGCCAATACATCGCTGTAGCAGGTTTCAATTCCTCATAGGTAAAATACTAACTTAGCACCTACCCGTTTTAAAACCCAGTTTACACCCTGTTTCAATTCCTCATAGGTAAAATACTAACTAATACCGGACAGAGCTTTCTGAACGCCTGTCCATGGTTTCAATTCCTCATAGGTAAAATACTAACCTAAATGTTCCTTGCAACGGTGCATGGGTAAAAATGTTTCAATTCCTCATAGGTAAAATACTAACTAGGCAAGTGAAGACAGACCAATGGGTTATGCCAAAGTTTCAATTCCTCATAGGTAAAATACTAAC

>NC_016023|6|5|1096065-1097943|CRISPRCasFinder
TTTTCAATTCCTCATAGGTAAAATACTAAC	TTCGGCGGCGGCAATTTGTGCCTCCCTCTTTGTCT
GTTTCAATTCCTCATAGGTAAAATACTAAC	GGTATTTTCCAACGTGTTTACTGACTGGAATACTGC
GTTTCAATTCCTCATAGGTAAAATACTAAC	ATCCACAGCTAACCAGGATTTGGTTTAGCAAAGCGAT
GTTTCAATTCCTCATAGGTAAAATACTAAC	TTCGGTTTATATCGTATCAACTCTAGTTTTACAGTCGC
GTTTCAATTCCTCATAGGTAAAATACTAAC	AAAAATATCGCGTCCAGCTAGTAGACTCAAACGAA
GTTTCAATTCCTCATAGGTAAAATACTAAC	ACGGCAAAAACAACGCCTTACTATGTCACAGCGAG
GTTTCAATTCCTCATAGGTAAAATACTAAC	ATACTCGAGGAAAGGCCTAGCAATTTATACGCGGT
GTTTCAATTCCTCATAGGTAAAATACTAAC	GTGCAGGCGGATATGCCTTACTCCAGCTTTTTTAA
GTTTCAATTCCTCATAGGTAAAATACTAAC	TTGCTTTTTGATTATCTCCAGTTTTTGCATTTTCG
GTTTCAATTCCTCATAGGTAAAATACTAAC	GGGCGCCTTACAAAATAGCATGAAAGGCGTAGGGGA
GTTTCAATTCCTCATAGGTAAAATACTAAC	CGGCGAGATCGGCGTGATTGTCGATAATATATCGGA
GTTTCAATTCCTCATAGGTAAAATACTAAC	GCCCAGCAGCGCACGAAAGCGCTCGGCCTGCTTCA
GTTTCAATTCCTCATAGGTAAAATACTAAC	TTAGCTTTGGGTCTCTCAACAACGCAATTAAAAAT
GTTTCAATTCCTCATAGGTAAAATACTAAC	AACGAGCAATTAGCATTGGATCTTTTTTAGAAGCCTT
GTTTCAATTCCTCATAGGTAAAATACTAAC	GCACGCCACGGAAAAACAGGCCATGGCGGAAATGC
GTTTCAATTCCTCATAGGTAAAATACTAAC	ATACTCGAGGAAAGGCCTAGCAATTTATACGCGGT
GTTTCAATTCCTCATAGGTAAAATACTAAC	GGTACAGCACAAAAAAATTAATAACTGGTCATTTTT
GTTTCAATTCCTCATAGGTAAAATACTAAC	ACAAATGCAGTTTGACTGGTACGTGGCTACCACTCCT
GTTTCAATTCCTCATAGGTAAAATACTAAC	TTTATACCGTTTTACAACTAAATGTACAGTATCTGGG
GTTTCAATTCCTCATAGGTAAAATACTAAC	GGCGAGGAGGCAAAGGATCTGATCGCGGCCGGATAT
GTTTCAATTCCTCATAGGTAAAATACTAAC	GCAAACGGTAATTTGCCCATACTGTGGCAAAAAAAG
GTTTCAATTCCTCATAGGTAAAATACTAAC	GGTGCACATTTTTGATTTGGTATAAAAAGCTATAGGTA
GTTTCAATTCCTCATAGGTAAAATACTAAC	CTAAAACGATATTTCACGGAAGTCGACGAGGACAAGCG
GTTTCAATTCCTCATAGGTAAAATACTAAC	CGCCAGATTGCGCCACGCCAATACATCGCTGTAGCAG
GTTTCAATTCCTCATAGGTAAAATACTAAC	TTAGCACCTACCCGTTTTAAAACCCAGTTTACACCCT
GTTTCAATTCCTCATAGGTAAAATACTAAC	TAATACCGGACAGAGCTTTCTGAACGCCTGTCCATG
GTTTCAATTCCTCATAGGTAAAATACTAAC	CTAAATGTTCCTTGCAACGGTGCATGGGTAAAAAT
GTTTCAATTCCTCATAGGTAAAATACTAAC	TAGGCAAGTGAAGACAGACCAATGGGTTATGCCAAA
GTTTCAATTCCTCATAGGTAAAATACTAAC

>NC_016023|6|2|1096065-1097943|CRT
TTTTCAATTCCTCATAGGTAAAATACTAAC	TTCGGCGGCGGCAATTTGTGCCTCCCTCTTTGTCT
GTTTCAATTCCTCATAGGTAAAATACTAAC	GGTATTTTCCAACGTGTTTACTGACTGGAATACTGC
GTTTCAATTCCTCATAGGTAAAATACTAAC	ATCCACAGCTAACCAGGATTTGGTTTAGCAAAGCGAT
GTTTCAATTCCTCATAGGTAAAATACTAAC	TTCGGTTTATATCGTATCAACTCTAGTTTTACAGTCGC
GTTTCAATTCCTCATAGGTAAAATACTAAC	AAAAATATCGCGTCCAGCTAGTAGACTCAAACGAA
GTTTCAATTCCTCATAGGTAAAATACTAAC	ACGGCAAAAACAACGCCTTACTATGTCACAGCGAG
GTTTCAATTCCTCATAGGTAAAATACTAAC	ATACTCGAGGAAAGGCCTAGCAATTTATACGCGGT
GTTTCAATTCCTCATAGGTAAAATACTAAC	GTGCAGGCGGATATGCCTTACTCCAGCTTTTTTAA
GTTTCAATTCCTCATAGGTAAAATACTAAC	TTGCTTTTTGATTATCTCCAGTTTTTGCATTTTCG
GTTTCAATTCCTCATAGGTAAAATACTAAC	GGGCGCCTTACAAAATAGCATGAAAGGCGTAGGGGA
GTTTCAATTCCTCATAGGTAAAATACTAAC	CGGCGAGATCGGCGTGATTGTCGATAATATATCGGA
GTTTCAATTCCTCATAGGTAAAATACTAAC	GCCCAGCAGCGCACGAAAGCGCTCGGCCTGCTTCA
GTTTCAATTCCTCATAGGTAAAATACTAAC	TTAGCTTTGGGTCTCTCAACAACGCAATTAAAAAT
GTTTCAATTCCTCATAGGTAAAATACTAAC	AACGAGCAATTAGCATTGGATCTTTTTTAGAAGCCTT
GTTTCAATTCCTCATAGGTAAAATACTAAC	GCACGCCACGGAAAAACAGGCCATGGCGGAAATGC
GTTTCAATTCCTCATAGGTAAAATACTAAC	ATACTCGAGGAAAGGCCTAGCAATTTATACGCGGT
GTTTCAATTCCTCATAGGTAAAATACTAAC	GGTACAGCACAAAAAAATTAATAACTGGTCATTTTT
GTTTCAATTCCTCATAGGTAAAATACTAAC	ACAAATGCAGTTTGACTGGTACGTGGCTACCACTCCT
GTTTCAATTCCTCATAGGTAAAATACTAAC	TTTATACCGTTTTACAACTAAATGTACAGTATCTGGG
GTTTCAATTCCTCATAGGTAAAATACTAAC	GGCGAGGAGGCAAAGGATCTGATCGCGGCCGGATAT
GTTTCAATTCCTCATAGGTAAAATACTAAC	GCAAACGGTAATTTGCCCATACTGTGGCAAAAAAAG
GTTTCAATTCCTCATAGGTAAAATACTAAC	GGTGCACATTTTTGATTTGGTATAAAAAGCTATAGGTA
GTTTCAATTCCTCATAGGTAAAATACTAAC	CTAAAACGATATTTCACGGAAGTCGACGAGGACAAGCG
GTTTCAATTCCTCATAGGTAAAATACTAAC	CGCCAGATTGCGCCACGCCAATACATCGCTGTAGCAG
GTTTCAATTCCTCATAGGTAAAATACTAAC	TTAGCACCTACCCGTTTTAAAACCCAGTTTACACCCT
GTTTCAATTCCTCATAGGTAAAATACTAAC	TAATACCGGACAGAGCTTTCTGAACGCCTGTCCATG
GTTTCAATTCCTCATAGGTAAAATACTAAC	CTAAATGTTCCTTGCAACGGTGCATGGGTAAAAAT
GTTTCAATTCCTCATAGGTAAAATACTAAC	TAGGCAAGTGAAGACAGACCAATGGGTTATGCCAAA
GTTTCAATTCCTCATAGGTAAAATACTAAC

>NC_016023|6|1|1096066-1097943|PILER-CR
TTTCAATTCCTCATAGGTAAAATACTAACT	TCGGCGGCGGCAATTTGTGCCTCCCTCTTTGTCTG
TTTCAATTCCTCATAGGTAAAATACTAACG	GTATTTTCCAACGTGTTTACTGACTGGAATACTGCG
TTTCAATTCCTCATAGGTAAAATACTAACA	TCCACAGCTAACCAGGATTTGGTTTAGCAAAGCGATG
TTTCAATTCCTCATAGGTAAAATACTAACT	TCGGTTTATATCGTATCAACTCTAGTTTTACAGTCGCG
TTTCAATTCCTCATAGGTAAAATACTAACA	AAAATATCGCGTCCAGCTAGTAGACTCAAACGAAG
TTTCAATTCCTCATAGGTAAAATACTAACA	CGGCAAAAACAACGCCTTACTATGTCACAGCGAGG
TTTCAATTCCTCATAGGTAAAATACTAACA	TACTCGAGGAAAGGCCTAGCAATTTATACGCGGTG
TTTCAATTCCTCATAGGTAAAATACTAACG	TGCAGGCGGATATGCCTTACTCCAGCTTTTTTAAG
TTTCAATTCCTCATAGGTAAAATACTAACT	TGCTTTTTGATTATCTCCAGTTTTTGCATTTTCGG
TTTCAATTCCTCATAGGTAAAATACTAACG	GGCGCCTTACAAAATAGCATGAAAGGCGTAGGGGAG
TTTCAATTCCTCATAGGTAAAATACTAACC	GGCGAGATCGGCGTGATTGTCGATAATATATCGGAG
TTTCAATTCCTCATAGGTAAAATACTAACG	CCCAGCAGCGCACGAAAGCGCTCGGCCTGCTTCAG
TTTCAATTCCTCATAGGTAAAATACTAACT	TAGCTTTGGGTCTCTCAACAACGCAATTAAAAATG
TTTCAATTCCTCATAGGTAAAATACTAACA	ACGAGCAATTAGCATTGGATCTTTTTTAGAAGCCTTG
TTTCAATTCCTCATAGGTAAAATACTAACG	CACGCCACGGAAAAACAGGCCATGGCGGAAATGCG
TTTCAATTCCTCATAGGTAAAATACTAACA	TACTCGAGGAAAGGCCTAGCAATTTATACGCGGTG
TTTCAATTCCTCATAGGTAAAATACTAACG	GTACAGCACAAAAAAATTAATAACTGGTCATTTTTG
TTTCAATTCCTCATAGGTAAAATACTAACA	CAAATGCAGTTTGACTGGTACGTGGCTACCACTCCTG
TTTCAATTCCTCATAGGTAAAATACTAACT	TTATACCGTTTTACAACTAAATGTACAGTATCTGGGG
TTTCAATTCCTCATAGGTAAAATACTAACG	GCGAGGAGGCAAAGGATCTGATCGCGGCCGGATATG
TTTCAATTCCTCATAGGTAAAATACTAACG	CAAACGGTAATTTGCCCATACTGTGGCAAAAAAAGG
TTTCAATTCCTCATAGGTAAAATACTAACG	GTGCACATTTTTGATTTGGTATAAAAAGCTATAGGTAG
TTTCAATTCCTCATAGGTAAAATACTAACC	TAAAACGATATTTCACGGAAGTCGACGAGGACAAGCGG
TTTCAATTCCTCATAGGTAAAATACTAACC	GCCAGATTGCGCCACGCCAATACATCGCTGTAGCAGG
TTTCAATTCCTCATAGGTAAAATACTAACT	TAGCACCTACCCGTTTTAAAACCCAGTTTACACCCTG
TTTCAATTCCTCATAGGTAAAATACTAACT	AATACCGGACAGAGCTTTCTGAACGCCTGTCCATGG
TTTCAATTCCTCATAGGTAAAATACTAACC	TAAATGTTCCTTGCAACGGTGCATGGGTAAAAATG
TTTCAATTCCTCATAGGTAAAATACTAACT	AGGCAAGTGAAGACAGACCAATGGGTTATGCCAAAG
TTTCAATTCCTCATAGGTAAAATACTAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_016023.1\|WP_014096364.1\|1098281_1099340_-\|phosphotransferase-family-protein	unknown	unknown	gnl\|CDD\|270703
NC_016023.1\|WP_014096369.1\|1103069_1104314_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173844
NC_016023.1\|WP_014096370.1\|1104501_1105521_-\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132912
NC_016023.1\|WP_014096368.1\|1102318_1103092_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|181295
NC_016023.1\|WP_029143158.1\|1093115_1093700_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379409
NC_016023.1\|WP_029142939.1\|1088146_1088476_-\|hypothetical-protein	unknown	unknown	unknown
NC_016023.1\|WP_174760514.1\|1084979_1085654_-\|phosphoadenylyl-sulfate-reductase	unknown	unknown	gnl\|CDD\|129526
NC_016023.1\|WP_014096367.1\|1100634_1102248_-\|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl\|CDD\|341259
NC_016023.1\|WP_014096366.1\|1100002_1100566_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380061
NC_016023.1\|WP_014096371.1\|1105719_1106439_-\|YebC/PmpR-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|237084
NC_016023.1\|WP_041818239.1\|1086593_1087997_+\|pectate-lyase	unknown	unknown	gnl\|CDD\|378931
NC_016023.1\|WP_014096373.1\|1107403_1108024_-\|hypothetical-protein	unknown	unknown	unknown
NC_016023.1\|WP_014096362.1\|1093875_1094424_+\|hypothetical-protein	unknown	unknown	unknown
NC_016023.1\|WP_019720423.1\|1086002_1086182_-\|hypothetical-protein	unknown	unknown	unknown
NC_016023.1\|WP_014096360.1\|1091199_1092663_-\|transposase	unknown	unknown	gnl\|CDD\|376573
NC_016023.1\|WP_014096353.1\|1083825_1084584_-\|uroporphyrinogen-III-C-methyltransferase	unknown	unknown	gnl\|CDD\|381169
NC_016023.1\|WP_014096358.1\|1088953_1090372_-\|NAD-dependent-succinate-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143421
NC_016023.1\|WP_014096372.1\|1106823_1107411_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274398
NC_016023.1\|WP_014096365.1\|1099382_1099787_-\|acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|223894
NC_016023.1\|WP_014096352.1\|1083078_1083819_-\|sirohydrochlorin-chelatase	unknown	unknown	gnl\|CDD\|225049

Protein	Function_ID	Function_description	E-value
NC_016023.1\|WP_014096364.1\|1098281_1099340_-\|phosphotransferase-family-protein	gnl\|CDD\|270703	cd05154, ACAD10_11_N-like, N-terminal domain of Acyl-CoA dehydrogenase (ACAD) 10 and 11, and similar proteins. This subfamily is composed of the N-terminal domains of vertebrate ACAD10 and ACAD11, and similar uncharacterized bacterial and eukaryotic proteins. ACADs are a family of flavoproteins that are involved in the beta-oxidation of fatty acyl-CoA derivatives. ACAD deficiency can cause metabolic disorders including muscle fatigue, hypoglycemia, and hepatic lipidosis. There are at least 11 distinct ACADs, some of which show distinct substrate specificities to either straight-chain or branched-chain fatty acids. ACAD10 is widely expressed in human tissues and highly expressed in liver, kidney, pancreas, and spleen. ACAD10 and ACAD11 are both significantly expressed in human brain tissues. They contain a long N-terminal domain with similarity to phosphotransferases with a Protein Kinase fold, which is absent in other ACADs. They may exhibit multiple functions in acyl-CoA oxidation pathways. ACAD11 utilizes substrates with carbon chain lengths of 20 to 26, with optimal activity towards C22CoA. ACAD10 may be associated with an increased risk in type II diabetes. The ACAD10/11-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).	1.0047e-86
NC_016023.1\|WP_014096369.1\|1103069_1104314_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173844	cd01155, ACAD_FadE2, Acyl-CoA dehydrogenases similar to fadE2. FadE2-like Acyl-CoA dehydrogenase (ACAD). Acyl-CoA dehydrogenases (ACAD) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACAD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. ACAD's are generally homotetramers and have an active site glutamate at a conserved position.	0
NC_016023.1\|WP_014096370.1\|1104501_1105521_-\|STAS-domain-containing-protein	gnl\|CDD\|132912	cd07041, STAS_RsbR_RsbS_like, Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation. The STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain of proteins related to RsbS and RsbR which are part of the "stressosome" complex that plays an important role in the regulation of the bacterial stress activated alternative sigma factor sigma-B. During stress conditions RsbS and RsbR are phosphorylated which leads to the release of RsbT, an activator of of the RsbU phosphatase, which in turn activates RsbV which leads to the release and activation of sigma factor B. RsbS is a single domain protein (STAS domain), while RsbR-like proteins have a well-conserved C-terminal STATS domain and a variable N-terminal domain. The STAS domain is also found in the C- terminal region of sulphate transporters and anti-anti-sigma factors.	4.16707e-36
NC_016023.1\|WP_029143158.1\|1093115_1093700_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|379409	pfam13977, TetR_C_6, BetI-type transcriptional repressor, C-terminal. This family comprises the C-terminal portion of proteins that belong to the TetR family of transcriptional regulators. The C-terminus represents the regulatory region, and does not include the DNA binding helix-turn-helix domain. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. One of the target proteins is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli.	7.75676e-17
NC_016023.1\|WP_174760514.1\|1084979_1085654_-\|phosphoadenylyl-sulfate-reductase	gnl\|CDD\|129526	TIGR00434, Phosphoadenosine_phosphosulfate_reductase, phosophoadenylyl-sulfate reductase (thioredoxin). This enzyme, involved in the assimilation of inorganic sulfate, is designated cysH in Bacteria and MET16 in Saccharomyces cerevisiae. Synonyms include phosphoadenosine phosphosulfate reductase, PAPS reductase, and PAPS reductase, thioredoxin-dependent. In a reaction requiring reduced thioredoxin and NADPH, it converts 3(prime)-phosphoadenylylsulfate (PAPS) to sulfite and adenosine 3(prime),5(prime) diphosphate (PAP). A related family of plant enzymes, scoring below the trusted cutoff, differs in having a thioredoxin-like C-terminal domain, not requiring thioredoxin, and in having a preference for 5(prime)-adenylylsulfate (APS) over PAPS. [Central intermediary metabolism, Sulfur metabolism].	8.11267e-109
NC_016023.1\|WP_014096367.1\|1100634_1102248_-\|long-chain-fatty-acid--CoA-ligase	gnl\|CDD\|341259	cd05936, FC-FACS_FadD_like, Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD. This subfamily of the AMP-forming adenylation family contains Escherichia coli FadD and similar prokaryotic fatty acid CoA synthetases. FadD was characterized as a long-chain fatty acid CoA synthetase. The gene fadD is regulated by the fatty acid regulatory protein FadR. Fatty acid CoA synthetase catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.	0
NC_016023.1\|WP_014096366.1\|1100002_1100566_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|380061	pfam17932, TetR_C_24, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in family members such as HTH-type transcriptional repressor KstR2 as well as fatty acid metabolism regulator proteins. In Mycobacterium smegmatis, KstR2 is involved in involved in cholesterol catabolism, while YsiA in Bacillus subtilis is involved in fatty acid degradation.	1.10425e-38
NC_016023.1\|WP_014096371.1\|1105719_1106439_-\|YebC/PmpR-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|237084	PRK12378, PRK12378, YebC/PmpR family DNA-binding transcriptional regulator.	7.3524e-139
NC_016023.1\|WP_041818239.1\|1086593_1087997_+\|pectate-lyase	gnl\|CDD\|378931	pfam12708, Pectate_lyase_3, Pectate lyase superfamily protein. This family of proteins possesses a beta helical structure like Pectate lyase. This family is most closely related to glycosyl hydrolase family 28.	5.59802e-16
NC_016023.1\|WP_014096365.1\|1099382_1099787_-\|acyl-CoA-thioesterase	gnl\|CDD\|223894	COG0824, FcbC, Predicted thioesterase [General function prediction only].	9.49926e-31
NC_016023.1\|WP_014096360.1\|1091199_1092663_-\|transposase	gnl\|CDD\|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	9.72772e-06
NC_016023.1\|WP_014096353.1\|1083825_1084584_-\|uroporphyrinogen-III-C-methyltransferase	gnl\|CDD\|381169	cd11642, SUMT, Uroporphyrin-III C-methyltransferase (also known as S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT). SUMT is an enzyme of the cobalamin and siroheme biosynthetic pathway. It catalyzes the first of three steps leading to the formation of siroheme from uroporphyrinogen III; it transfers two methyl groups from S-adenosyl-L-methionine to the C-2 and C-7 atoms of uroporphyrinogen III to yield precorrin-2 via the intermediate formation of precorrin-1. Precorrin-2 is also a precursor for the biosynthesis of vitamin B12, coenzyme F430, siroheme and heme d1. This family includes proteins in which the SUMT domain is fused to other functional domains, such as to a uroporphyrinogen-III synthase domain to form bifunctional uroporphyrinogen-III methylase/uroporphyrinogen-III synthase, or to a dual function dehydrogenase-chelatase domain, as in the case of the multifunctional S-adenosyl-L-methionine (SAM)-dependent bismethyltransferase/dehydrogenase/ferrochelatase CysG, which catalyzes all three steps that transform uroporphyrinogen III into siroheme.	1.34632e-129
NC_016023.1\|WP_014096358.1\|1088953_1090372_-\|NAD-dependent-succinate-semialdehyde-dehydrogenase	gnl\|CDD\|143421	cd07103, ALDH_F5_SSADH_GabD, Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like. Succinate-semialdehyde dehydrogenase, mitochondrial (SSADH, GabD, EC=1.2.1.24) catalyzes the NAD+-dependent oxidation of succinate semialdehyde (SSA) to succinate. This group includes the human aldehyde dehydrogenase family 5 member A1 (ALDH5A1) which is a mitochondrial homotetramer that converts SSA to succinate in the last step of 4-aminobutyric acid (GABA) catabolism. This CD also includes the Arabidopsis SSADH gene product ALDH5F1. Mutations in this gene result in the accumulation of H2O2, suggesting a role in plant defense against the environmental stress of elevated reactive oxygen species.	0
NC_016023.1\|WP_014096372.1\|1106823_1107411_-\|hypothetical-protein	gnl\|CDD\|274398	TIGR03025, EPS_sugtrans, exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase. Members of this family are generally found near other genes involved in the biosynthesis of a variety of exopolysaccharides. These proteins consist of two fused domains, an N-terminal hydrophobic domain of generally low conservation and a highly conserved C-terminal sugar transferase domain (pfam02397). Characterized and partially characterized members of this subfamily include Salmonella WbaP (originally RfbP), E. coli WcaJ, Methylobacillus EpsB, Xanthomonas GumD, Vibrio CpsA, Erwinia AmsG, Group B Streptococcus CpsE (originally CpsD), and Streptococcus suis Cps2E. Each of these is believed to act in transferring the sugar from, for instance, UDP-glucose or UDP-galactose, to a lipid carrier such as undecaprenyl phosphate as the first (priming) step in the synthesis of an oligosaccharide "block". This function is encoded in the C-terminal domain. The liposaccharide is believed to be subsequently transferred through a "flippase" function from the cytoplasmic to the periplasmic face of the inner membrane by the N-terminal domain. Certain closely related transferase enzymes, such as Sinorhizobium ExoY and Lactococcus EpsD, lack the N-terminal domain and are not found by this model.	0.00463684
NC_016023.1\|WP_014096368.1\|1102318_1103092_-\|SDR-family-oxidoreductase	gnl\|CDD\|181295	PRK08213, PRK08213, gluconate 5-dehydrogenase; Provisional.	7.52467e-147
NC_016023.1\|WP_014096352.1\|1083078_1083819_-\|sirohydrochlorin-chelatase	gnl\|CDD\|225049	COG2138, COG2138, Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism].	3.23667e-35

>NC_016023.1|WP_014096362.1|1093875_1094424_+|hypothetical-protein
MNWIIWLIIACEIGFWVFILLGLSFRYLLKKEKLGFIFLALTPVVDLILIIAATFDLYSGTTATKAHALAAIYIGISVGFGKSMIRWADEHFQYYITKTGPKPVKLYGLQFAKQNLKSWGRHLLSYLIGASLIGIIYYFINDYERTKALIQVLGIWSLVLIIDLLISLSYFVFPRQPGKPTI
>NC_016023.1|WP_029143158.1|1093115_1093700_-|TetR-family-transcriptional-regulator
MPKIVDHDNRKKAIAEATWQVILEQGMKGATVRNIARKAGLSLGALRHYFSTQEELLIYAMDLVKERVAERVEKIALKNLPPKEMILQMLLEIVPTNETTRAEMEVWLEFVLYFRNKGNRESQNDGILEGIQKLLDSLDRAQFLKKEIDKDLETERLCALIDGLAIHAILNPTRLTKERIISILAHHIDEICHF
>NC_016023.1|WP_014096360.1|1091199_1092663_-|transposase
MTISILTQTRDFSIQQNLIPHNWQDYADIPFVIPSMCFPWEIFKPIEREYYTLLYLHLKNERAHDPSNEIQPALFSITEEEDKSASSLFHLPSTGRKPHPFMPFFRAFELASLQYIEVMVESVYLQVKSNPLFATMCGFTEKIPSYRSFARFDQIMTTNGLWEKARLLVVEYHKGEGVVETNEEAAAVDTSHIEAEATLNKTRKTCSCEGNCDCPRVLTDDNVGVMRKSNAVSYIAHKLSMVSGVRSGLPLTREVFKGNTPDGKTLEPTLETFKAEHPEMAEQLSFILADGIYQTPENQKVTKDVLQAKLVAPINPRNRKDKPTTARGIEKINRYGTPICISGHKMELRGSDREKGQYIYTCPVFHPNAKQEGLTCPLANHAECCNGAAQGRVFRIDFDQTPQVDVELPQHGRTFEVLYSARTVIERIFGILKDGYSLRRVHKRGKQAVEAHVDRCMISMHIMANMAYHQTGKANCGWTRNRLQRAN
>NC_016023.1|WP_014096358.1|1088953_1090372_-|NAD-dependent-succinate-semialdehyde-dehydrogenase
MEDYLMYLNGEWTGEGLPKIKVDNPASGEVIATIPKGGEKEAKLAVDAAHAAFPAWAALSAYERSAYLRTWFELIRQHENELARTMTIEQGKPLKEALGEMRYANGFIEWFAEEGKRVYGETIPASATNKRLFVHKQPVGVVAAITPWNFPAAMITRKVAPALAAGCTVVIKPAKQTPLTALKLAELAAKAGIPKGVMNVITGSAKEIGDTWLADERVRKLTFTGSTEIGKELMRGSADTVKKVSLELGGHAPVIITKHADLDKAAEGTVAAKFRNAGQTCVCSNRIYVQEEVYEAFTKKFTEKVKALRVGDGLAEGTDIGPLIDRNAVEKVEHHVKDAVEKGATVETGGSAKDGLFFEPTVISNVTDEMICMKEETFGPLAPVTKFTDIDEAIRRANDSIYGLAAYVFTENISEGIQIAEGLEYGIVGLNDGLPSTPQAPFGGFKQSGLGREGGRYGIEEFLEVKYISLGL
>NC_016023.1|WP_029142939.1|1088146_1088476_-|hypothetical-protein
MQDEAKPVKILYRNVFRRHHHDKRHQVSPGNDFYRGLKMTNIRKSSSEKNASAARGIKQPARIFRTPIHAAAGAATPENENGQTHIFKIEACRIGYGMGKRMKIGRHNF
>NC_016023.1|WP_041818239.1|1086593_1087997_+|pectate-lyase
MIHLDKHHDPRTNGMLLRQLSRRAVQPGTLIQENEALFQKYCQPEFHKPFSLSRLLLNRRYPVEPYKTLADQNGLVYPEWKTILDQEYSRLLSVASRTVNVADFGAAGDGKTDCTAAFQKALGNGRVKVIVPEGIYLVKGLKLPSWTCLCGSGKGVTVIKLHPHAPKKTRLIQNAHFHRGNHHISVEGLSLDWNVERLGNEERTAAGNNRSSCLTFAHVTFGWVKNVEAAGAGLHGFDVSSARYHYLGDGFLAPGRSRYIWLDGLTASGFGDDGITTHHSDYCFISNSFCYNPSGKAHKKGFSNSNGIEIDDGSRHVWLYNNASSGCFGGVEIKAHHNASAASHVHLYGHLSVRDNRSFNFRHIGHHKGKDSDSKSADHIVAANLVSIAPVFTDLYEGSTPRSLVVSAYRNVVINGLTALGDPDYDFKGNPVVAIQYRAKNVILKNVEISGFQNAKRIKGKDKCVLL
>NC_016023.1|WP_019720423.1|1086002_1086182_-|hypothetical-protein
MASKIQVMMKRGAEPVRRKFKGELMNRFGTEQDLKKTHASKDWKPFHQMRKKKVAQNYM
>NC_016023.1|WP_174760514.1|1084979_1085654_-|phosphoadenylyl-sulfate-reductase
MFVPEDETKGALEILQWAYGTYGKSVVYACSFGAEGMVLIDLISKVREDADIVFLDTDLHFPQTYELIEKVKKKYPALNIQMKKPSLTLDEQAAQYGSALWKRDPDQCCYIRKIKPLEETLQGASAWISGLRREQSPTRAKTNFVNKDERFHSIKICPLIHWTWDDVWNYIKSHHLPYNELHDQGYPSIGCFPCTRAAGNSDSRAGRWAGFHKTECGLHTVQKK
>NC_016023.1|WP_014096353.1|1083825_1084584_-|uroporphyrinogen-III-C-methyltransferase
MRKVYLVGAGPGDLELITVKGLRLIREADVILYDRLVNPDLLKEARLDAELVYCGKKPDAHTMTQDMINHLLVKFANQGKTVVRLKGGDPFIFGRGGEEAEVLVQKHIPFEIVPGITAGSAVPAYAGIPLTHRGLSTSVAFIAGVTKKGEDLDAYWSKYAGIDTLCIYMGVKNLPLICAQLIKHGKSPDMPAALIRWGTTEKQETAVGTLGNLSKKAAGLRNPSLLIIGEVVKLREELKWFEQLSAASACTG
>NC_016023.1|WP_014096352.1|1083078_1083819_-|sirohydrochlorin-chelatase
MKQGVLYVSHGSRVPETAREATATIRQAMAQVDADLQEICYLEIAEPDIAAGIDALVRGGTGRIAVVPVLLLSAGHYYEDIPRAIREAKQRYPHIVFTYGRPLGVGDRIIGILTENIMETGMPPGAWILLVGRGSRNPETLCDFAKIAARLCAQLGTEQIKTAYLAVLEPRFDDALKELTATGRPVVVAPYLWFTGVLVRSLEKKVGMLQREGYDIRLARYLGCHPDMADALAVRAKEALGAEDFI
>NC_016023.1|WP_014096364.1|1098281_1099340_-|phosphotransferase-family-protein
MNSDTIPVRKGEELDLTRLQQYLREKLPQMPDAPLEVAQFSAGRSNLTYQLKASSWEAVLRRPPLGPVAPKAHDMGREFRVLKALRPFFAPAPEVLLFEEDPFVIGAPFFLMERKHGIVLDTAFPPGVEPKKETCRRISSIMVDRLVELHAIPYEETELLSMSKPAGFLERQVNGWIERYLRAKTDEIPEAEPLIHYLRDHIPPQQGAAVIHYDYKLNNAMFNEDFSEMTGLFDWEMATIGDPLADLGAALSYWTEKDDPDLIKNGLGEPSVTTLDGFMTRREFVEAYAKKSGRDVSNIDYYLIFGYFKLAGICQQIYYRYKRGQTQDRRFAHFGNVVRSLIRHAVEVAERV
>NC_016023.1|WP_014096365.1|1099382_1099787_-|acyl-CoA-thioesterase
MHELKLRTRFCETDAIGHINNTSYFIYLEDARLKFFESIGASVEIKDFNIILASVKCDFISQAFYNEELTIRTGVAKLGNTSCELAHEMLDAETGRLIAKGKAVVVFFDFDNQQSRPIPDDIRGILEKHLQPVM
>NC_016023.1|WP_014096366.1|1100002_1100566_-|TetR-family-transcriptional-regulator
MKAKITEHSIRLFEQKGFTETSIQDIVDSIGATKGTFYYYFSSKEQLLMDIHMDYITKLLEKQKAILSENGSCKAKLHALVLMLLESIKTEKAKALIFFREIKNLSGEKLELILQKREAFRLGVEKLIREGIEIGEFAGHLDANLTSFAILGMVNWSYQWFQPEGRKSAAEVAELFMDIVLHGIEKA
>NC_016023.1|WP_014096367.1|1100634_1102248_-|long-chain-fatty-acid--CoA-ligase
MENKVWHAVYTDEIPKEIEVLDIPLYQILATAAEKYPDRTALSFYGRKTPYAELYKASLAFASSLQKRGVQKGSRVAVMLPNCPHYVVSYYGALMAGAMVVQINPMLVEPEIRHILNDSGAETIIVLDDLYPKVQAVRPETSLKNVVIAGFKPAAGPLDEAEPFDALLQAGTDYNPPALDPWEDIAVLQYTGGTTGRSKGAMLTHRNLLANLVQTYEFFKPVMGPGKERILTVIPLFHVFGMTCAMNYAIYTGSESVMLPRFDLEEVLKTIKETQPTYFPGVPTMYVAITNHPKAMEYGLDSIKTCNSGSAPMPLGLLRQFEEKTGSVIVEGYGLSEASPVTHCNPVFGKRKPGSIGIAIPSTDYKIVDVATGTEELKPGETGELIVKGPQVMKGYWNMPEETAEALRDGWLYTGDIATMDEEGYAYIVDRKKDMIIASGYNVYPRDVEEVLYAHPAVQEAVVIGVPDPYRGETVKAFVVLKEGQKMTEEALIEYASAHLAPYKRPKIIEFRDALPKTNVGKILRRKLRDEERKVRE
>NC_016023.1|WP_014096368.1|1102318_1103092_-|SDR-family-oxidoreductase
MNVLELFSLKGKTAIVTGGGRGLGEQIARAFAEAGADVVLCSRKKAACEEAAARIESLGVRALAMECDITNRTQVDEVVAETVKQFGKIDILVNNSGATWGAPAEDMPVEAWEKVISTNVTGTFHMSQAAGKAMIKQGHGKIINIASIAGLGGVDPRIMDTIGYNTSKGAVITFTKDLAAKWGRYGIHVNAIAPGFFPTKMAKVIIERGKNPILEATPLGRFGNDQDLKGAAVFLASAASDYVTGDVLLVDGGMHVL
>NC_016023.1|WP_014096369.1|1103069_1104314_-|acyl-CoA-dehydrogenase
MDFDYSPKVKALISKLERFMEENVYPGEKIFEEQLNAQETRWAAVPPIMEELKAKAKQEGLWNLFLPDNEYGAGLSNLEYAPLCEIMGRSIIAPEVFNCNAPDTGNMEVLARYGSDEQKEKWLKPLLNGEIRSCFSMTEPDTASSDATNISCSIVRDGDEYIVNGRKWWSSGAGDPRCKIAIVMGKTNPDAPRHEQQSMILVPLDTPGVKIERMLPVFGYDDAPHGHAEITYENVRVPAENIIWGEGKGFAIAQGRLGPGRIHHCMRLIGAAERALELLCKRIQNRAPFGKPLAEQGVIRQWVAESRIEIEQARLLTLKAAYRMDTVGNKVARKEIAMIKAVAPRMALAVIDRAIQAFGGAGVSDDFPLARLWANARTLRLADGPDEVHLDQIARLEIKPYQERGSADERVRTV
>NC_016023.1|WP_014096370.1|1104501_1105521_-|STAS-domain-containing-protein
MSEHPNIHVGGLQFEWELEKGRFIFEGEDAVLFWIPTAMRDLFTTIEEISGEEASNVVFETAGFRQGLLVADYFNKIKDFDVKKASELITTTYASAGWGRAVMKDMNFDQKTLTIELKDSWEHKINVAQGKKTGSNFLPAHYAGIFTGLFHTNIWYKVVRYQIEGHDSTIIEYFPSDITVSHNIHQLARKKEAEQIIQLEALVEDKTRELKELIKQLSSPIIPILDGIVVVPLIGKYDDERAEELVEKTLKNLPQYKAKYLVLDLTALDVEDDPHSIQFIENIGKASSLIGTQTILVGISPSMSMTISSSGLDFSQFDCFQTLQHSIHYALGQLGRKIL
>NC_016023.1|WP_014096371.1|1105719_1106439_-|YebC/PmpR-family-DNA-binding-transcriptional-regulator
MGRKWNNIKDKKAARDANTSRIYAKFGREIYVAAKQGVPDPVANSALKMVLERAKTYSVPKAIIDRAIEKAKGGADENYDELRYEGFGPGGSMIIVDTLTNNVNRTASEVRAAFGKNGGNMGVSGSVAYMFDKTAVFGIEGKTADEVLELLLEADIDVRDVFEEDGAVIVYAEPDQFHAVQEAFENAGITEFTVAELTMLPQNEVTLPDEDREKFEKLIDVLEDLEDVQQIYHNVNLDD
>NC_016023.1|WP_014096372.1|1106823_1107411_-|hypothetical-protein
MYKKESGNMDRKIVFGISLVYVLWMAVLCAMQYTAGASWKAAVAAGGVISGAIPLILSWVPRLRFHLPLVISYFLFLTGSQYFGSIRGWYGLGWWDTFLHFVSGLLLGFAAIALYERLVHRDAGKAISAWFVFLFVLGFAALGGVMWEIYEFSGDQFFGTTLQGGGNKDTMTDLIADVLGGLVVATGSGIRTKRK
>NC_016023.1|WP_014096373.1|1107403_1108024_-|hypothetical-protein
MEKERVSYFWKRTERGGKVKRIIIILLSTGMMLLLAGLMVYFIIKHDTLRWGIAAGGIVLSTLPLGLLFLKHNRINTPSIIGWYIFVICSICLGSIAGFYGRFSWWDTSVHFYKGIFTACIGVTLYKILVPEAARRGMSRLIPALFALGLAITGSVLWEMYEFLGDVIASHTMQRGGNTDTMVDLLAGFFGGVLIAIYTGFRKQNV

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_016023_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016023_7

1279191-1279281

Orphan

Consensus_repeat	Method
TATGCTTGTTCCAGCAAAAGACGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_016023_7

>merge|NC_016023|7|1279191-1279281|CRISPRCasFinder
TATGCTTGTTCCAGCAAAAGACGGGATAATGGAATTGCCACTGTACCACGAGTGCCCCCGCCAGGCTATGCTTGTTCCAGCAAAAGACGGG

>NC_016023|7|6|1279191-1279281|CRISPRCasFinder
TATGCTTGTTCCAGCAAAAGACGGG	ATAATGGAATTGCCACTGTACCACGAGTGCCCCCGCCAGGC
TATGCTTGTTCCAGCAAAAGACGGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_016023.1\|WP_014096523.1\|1279580_1280057_-\|2-C-methyl-D-erythritol-2,4-cyclodiphosphate-synthase	unknown	unknown	gnl\|CDD\|376811
NC_016023.1\|WP_017551231.1\|1272283_1272430_-\|50S-ribosomal-protein-L33	unknown	unknown	gnl\|CDD\|234783
NC_016023.1\|WP_014096514.1\|1271379_1271913_-\|transcription-termination/antitermination-protein-NusG	unknown	unknown	gnl\|CDD\|180161
NC_016023.1\|WP_014096522.1\|1277567_1279028_-\|glutamate--tRNA-ligase	unknown	unknown	gnl\|CDD\|234953
NC_016023.1\|WP_014096519.1\|1274709_1275123_-\|Mini-ribonuclease-3	unknown	unknown	gnl\|CDD\|224850
NC_016023.1\|WP_014096528.1\|1283841_1286292_-\|ATP-dependent-Clp-protease-ATP-binding-subunit	unknown	unknown	gnl\|CDD\|214361
NC_016023.1\|WP_014096524.1\|1280059_1280740_-\|2-C-methyl-D-erythritol-4-phosphate-cytidylyltransferase	unknown	unknown	gnl\|CDD\|234670
NC_016023.1\|WP_014096525.1\|1280806_1281892_-\|PIN/TRAM-domain-containing-protein	unknown	unknown	gnl\|CDD\|227292
NC_016023.1\|WP_100183740.1\|1288691_1288949_-\|DUF3969-family-protein	unknown	unknown	gnl\|CDD\|372479
NC_016023.1\|WP_014096533.1\|1294958_1295225_-\|pro-sigmaK-processing-inhibitor-BofA-family-protein	unknown	unknown	gnl\|CDD\|163046
NC_016023.1\|WP_014096516.1\|1272738_1273389_-\|RNA-polymerase-sporulation-sigma-factor-SigH	unknown	unknown	gnl\|CDD\|181361
NC_016023.1\|WP_014096526.1\|1282238_1283609_-\|DNA-repair-protein-RadA	unknown	unknown	gnl\|CDD\|236994
NC_016023.1\|WP_014096529.1\|1286308_1287376_-\|protein-arginine-kinase	unknown	unknown	gnl\|CDD\|234894
NC_016023.1\|WP_014096518.1\|1273966_1274710_-\|23S-rRNA-(guanosine(2251)-2'-O)-methyltransferase-RlmB	unknown	unknown	gnl\|CDD\|129290
NC_016023.1\|WP_013858048.1\|1287940_1288402_-\|CtsR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|226869
NC_016023.1\|WP_026684122.1\|1273455_1273965_-\|NYN-domain-containing-protein	unknown	unknown	gnl\|CDD\|226213
NC_016023.1\|WP_014096530.1\|1287375_1287921_-\|UvrB/UvrC-motif-containing-protein	unknown	unknown	gnl\|CDD\|226397
NC_016023.1\|WP_014096521.1\|1276497_1277166_-\|serine-O-acetyltransferase	unknown	unknown	gnl\|CDD\|223975
NC_016023.1\|WP_014096520.1\|1275119_1276517_-\|cysteine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234705
NC_016023.1\|WP_014096515.1\|1272062_1272248_-\|preprotein-translocase-subunit-SecE	unknown	unknown	gnl\|CDD\|236066

Protein	Function_ID	Function_description	E-value
NC_016023.1\|WP_014096523.1\|1279580_1280057_-\|2-C-methyl-D-erythritol-2,4-cyclodiphosphate-synthase	gnl\|CDD\|376811	pfam02542, YgbB, YgbB family. The ygbB protein is a putative enzyme of deoxy-xylulose pathway (terpenoid biosynthesis).	8.76229e-103
NC_016023.1\|WP_017551231.1\|1272283_1272430_-\|50S-ribosomal-protein-L33	gnl\|CDD\|234783	PRK00504, rpmG, 50S ribosomal protein L33; Validated.	3.43221e-14
NC_016023.1\|WP_014096514.1\|1271379_1271913_-\|transcription-termination/antitermination-protein-NusG	gnl\|CDD\|180161	PRK05609, nusG, transcription antitermination protein NusG; Validated.	6.48023e-95
NC_016023.1\|WP_014096522.1\|1277567_1279028_-\|glutamate--tRNA-ligase	gnl\|CDD\|234953	PRK01406, gltX, glutamyl-tRNA synthetase; Reviewed.	0
NC_016023.1\|WP_014096519.1\|1274709_1275123_-\|Mini-ribonuclease-3	gnl\|CDD\|224850	COG1939, COG1939, Ribonuclease III family protein [Replication, recombination, and repair].	5.97073e-61
NC_016023.1\|WP_014096528.1\|1283841_1286292_-\|ATP-dependent-Clp-protease-ATP-binding-subunit	gnl\|CDD\|214361	CHL00095, clpC, Clp protease ATP binding subunit.	0
NC_016023.1\|WP_014096524.1\|1280059_1280740_-\|2-C-methyl-D-erythritol-4-phosphate-cytidylyltransferase	gnl\|CDD\|234670	PRK00155, ispD, D-ribitol-5-phosphate cytidylyltransferase.	4.8734e-112
NC_016023.1\|WP_014096525.1\|1280806_1281892_-\|PIN/TRAM-domain-containing-protein	gnl\|CDD\|227292	COG4956, COG4956, Integral membrane protein (PIN domain superfamily) [General function prediction only].	3.9088e-178
NC_016023.1\|WP_100183740.1\|1288691_1288949_-\|DUF3969-family-protein	gnl\|CDD\|372479	pfam13108, DUF3969, Protein of unknown function (DUF3969). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 110 amino acids in length.	1.63373e-07
NC_016023.1\|WP_014096533.1\|1294958_1295225_-\|pro-sigmaK-processing-inhibitor-BofA-family-protein	gnl\|CDD\|163046	TIGR02862, Sigma-K_factor-processing_regulatory_protein_BofA, pro-sigmaK processing inhibitor BofA. Members of this protein family are found only in endospore-forming bacteria, such as Bacillus subtilis and Clostridium tetani. Among such bacteria, it appears only Symbiobacterium thermophilum lacks a member of this family. The protein, designated BofA, is an integral membrane protein that regulates the proteolytic activation of the RNA polymerase sigma factor K. [Cellular processes, Sporulation and germination].	1.78409e-10
NC_016023.1\|WP_014096516.1\|1272738_1273389_-\|RNA-polymerase-sporulation-sigma-factor-SigH	gnl\|CDD\|181361	PRK08295, PRK08295, RNA polymerase sporulation sigma factor SigH.	5.52162e-120
NC_016023.1\|WP_014096526.1\|1282238_1283609_-\|DNA-repair-protein-RadA	gnl\|CDD\|236994	PRK11823, PRK11823, DNA repair protein RadA; Provisional.	0
NC_016023.1\|WP_014096529.1\|1286308_1287376_-\|protein-arginine-kinase	gnl\|CDD\|234894	PRK01059, PRK01059, ATP:guanido phosphotransferase; Provisional.	0
NC_016023.1\|WP_014096518.1\|1273966_1274710_-\|23S-rRNA-(guanosine(2251)-2'-O)-methyltransferase-RlmB	gnl\|CDD\|129290	TIGR00186, Uncharacterized_tRNA/rRNA_methyltransferase_MG252, rRNA methylase, putative, group 3. this is part of the trmH (spoU) family of rRNA methylases [Protein synthesis, tRNA and rRNA base modification].	5.28043e-99
NC_016023.1\|WP_013858048.1\|1287940_1288402_-\|CtsR-family-transcriptional-regulator	gnl\|CDD\|226869	COG4463, CtsR, Transcriptional repressor of class III stress genes [Transcription].	7.71878e-73
NC_016023.1\|WP_026684122.1\|1273455_1273965_-\|NYN-domain-containing-protein	gnl\|CDD\|226213	COG3688, COG3688, Predicted RNA-binding protein containing a PIN domain [General function prediction only].	3.74279e-75
NC_016023.1\|WP_014096530.1\|1287375_1287921_-\|UvrB/UvrC-motif-containing-protein	gnl\|CDD\|226397	COG3880, COG3880, Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms].	3.16274e-59
NC_016023.1\|WP_014096521.1\|1276497_1277166_-\|serine-O-acetyltransferase	gnl\|CDD\|223975	COG1045, CysE, Serine acetyltransferase [Amino acid transport and metabolism].	5.02969e-103
NC_016023.1\|WP_014096520.1\|1275119_1276517_-\|cysteine--tRNA-ligase	gnl\|CDD\|234705	PRK00260, cysS, cysteinyl-tRNA synthetase; Validated.	0
NC_016023.1\|WP_014096515.1\|1272062_1272248_-\|preprotein-translocase-subunit-SecE	gnl\|CDD\|236066	PRK07597, secE, preprotein translocase subunit SecE; Reviewed.	2.34704e-14

>NC_016023.1|WP_014096522.1|1277567_1279028_-|glutamate--tRNA-ligase
MANEIRVRYAPSPTGFLHIGNARTALFNYLFARSKGGKFIIRIEDTDQKRNVEGGVESQLKYLKWLGIDWDESIDVGGEYGPYRQSERLDIYKKYYEDLLDRGLAYKCYCTEEELEAEREAQLARGVMPRYSGKCRHLTEEDRKRLEAEGRKPSLRFHVPEGKVYTFNDIVKGEVSFESDGIGDFVIVKKDGMPTYNFAVTIDDHLMKISHVLRGDDHISNTPKQLMIYEAFGFEPPVFGHMTLIVNEHRKKLSKRDGSIIQFIEQYAELGYLPEALFNFIAMLGWSPKGEEEIFSREEFIQIFDPERLSKSPALFDRQKLAWMNNQYMKKLDLDKVVELALPHLVKAGLVPENRTPEEEQWVRKLISLYQEQMSYGAEIVELSKPLFFTDEITYDEEAKEILSGEHVPEVLRAFLEELDRIEPFEAGEIKKAIKAVQKATGQKGKKLFMPIRVAVSGQTHGPELQSLIELLGREKVKKRLERITG
>NC_016023.1|WP_014096521.1|1276497_1277166_-|serine-O-acetyltransferase
MFKRLKEDIEVVFDQDPAARTYFEVILTYSGLHAIWAHRIAHFFYKKKMFFIARVISQLSRFFTGIEIHPGAQIGRRFFIDHGMGVVIGETCEIGDNVTVYQGVTLGGTGKEKGKRHPTIKDNALIASGAKVLGSITIGENAKIGAGSVVLKDVPPNSTVVGIPGRVVVQDGVKIKKDLKHNELPDPVADRLNSMQQEIEALRSELEQLRKEGARMYEHSDI
>NC_016023.1|WP_014096520.1|1275119_1276517_-|cysteine--tRNA-ligase
MSIQIYNTLTRKKEPFIPLEEGKVKMYVCGPTVYNYIHIGNARPAIVFDTVRRYLAFRGYDVNYVSNFTDVDDKLIKAAKERGEEVPALSERFIKSYFEDIDALGCCHADAHPRVTENMDAIIAFIEKLIEKGHAYESGGDVYYHTRSFPDYGKLSHQSIDELKSGARIEVGEKKEDALDFALWKAAKEGEISWDSPWGKGRPGWHIECSAMAKKYLGDTIDIHAGGQDLTFPHHENEIAQSEALTDKPFARYWMHNGYINIDNEKMSKSLGNIVLVHDIIERHDPQVLRFFMLSVHYRHPINYSEELLANAKAGLERIKTSYQNVKHRLESSANLAEDDEKWLEQVRSLHRQFIEAMDDDFNTANGISVLFELSKQANYYLRGKNTTETVLRAFMKEFETISGVLGLKLEEEVLLDEEIEALIEKRNEARKARNFQLADEIRDKLKSMNIILEDTPQGVRWRRL
>NC_016023.1|WP_014096519.1|1274709_1275123_-|Mini-ribonuclease-3
MTVTLDPKQLNSLALAYMGDAVYEEYIRHHVLLQGKTKPNRLHREAIRFVSAKAQAQILKQMMNENLLTEEETAVVRRGRNAKSGTVPKNTDVQTYRHSTAFEALIGYHYLSGSRERMEALIKKAIDIVEDQKGGAH
>NC_016023.1|WP_014096518.1|1273966_1274710_-|23S-rRNA-(guanosine(2251)-2'-O)-methyltransferase-RlmB
MDQEYIAGKNPVLEALRAGREINKIWIAEGSQKGAMKQVIELARERKVTVQFVPKKKIDQVADGAHQGVLALVAAYRYAETGDMFKLAKERNEHPFILILDELEDPHNLGSILRTADAVGAHGVIIPKRRSVALTATVAKASTGAIEHIPVARVTNLSQTIAGLKQQGLWIAGTDASGTTDYRQMDADLPLCLVIGSEGKGMSRIVKEACDFLIRLPMAGHVTSLNASVAAGLLMYEVYRKRHPLGE
>NC_016023.1|WP_026684122.1|1273455_1273965_-|NYN-domain-containing-protein
MNILLVDGYNIIGAWPELQKLKQKDLGAARDRLVEIMAEYQGYTDDKVIVVFDAYGVKGLEKKYRYHKVEVIFTKENETADERIEKMAIKLNNIRTQIYVATSDFTEQWQIFGQGALRISARELLTKVEMIEQKIKKNVKSIQEEKPATRIPLSQEVMEIFEKLRRGKR
>NC_016023.1|WP_014096516.1|1272738_1273389_-|RNA-polymerase-sporulation-sigma-factor-SigH
MNLNIEAAYEERYGTMQDEELVGRIHNGESEALDYLIQKYRNFVRAKARSYFIIGADREDIIQEGMIGLYKAIRDYREDKLTSFKAFAELCINRQMITAIKTATRQKHIPLNSYISLDKPIYDEESDRTLMDVITGAKISNPEELILIREKYVHIEVKISELLSDLERKVLALYLDGQSYQEISEELNRHVKSIDNALQRVKKKLERLLEMREMTY
>NC_016023.1|WP_017551231.1|1272283_1272430_-|50S-ribosomal-protein-L33
MQKKMVLACSVCGSRNYTTTTGNGKAERMELKKFCKHCNEHTIHRGTK
>NC_016023.1|WP_014096515.1|1272062_1272248_-|preprotein-translocase-subunit-SecE
MSITNFFRNVASEMRKVSWPGRKELVKYTITVLVTVAFLTLFFIVIDLGISAVIRWAENSL
>NC_016023.1|WP_014096514.1|1271379_1271913_-|transcription-termination/antitermination-protein-NusG
MEKNWYVVHTYSGYENKVKTNLEKRVESMGMQDKIFRVVVPEEEELEVKNEKKKVVKRKVFPGYVLVEMVMTDDSWYVVRNTPGVTGFVGSSGGGSKPTPLLPEEINTILKRMGMEEKRADVDFEIGETVTVKEGPFANFAGKIVEMDRDKGRAKVMVNMFGRDTPVELVFEQIDKI
>NC_016023.1|WP_014096523.1|1279580_1280057_-|2-C-methyl-D-erythritol-2,4-cyclodiphosphate-synthase
MFRIGQGFDVHRFGEGRPLMIGGVEIPYEKGLLGHSDADVLLHAVADACLGAIGEGDIGRHFPDTDAAFKDADSAALLAHVFQLVKQKGYKLGNLDCTIIAQKPKMAPYIGKMRETIARILEAEIGQVNVKATTTEKLGFAGREEGIAAQAAVLLEQA
>NC_016023.1|WP_014096524.1|1280059_1280740_-|2-C-methyl-D-erythritol-4-phosphate-cytidylyltransferase
MTDYEVIIPAAGSGKRMGAGFNKLFLELNKRPVIAVTAEVFLADPSCKKLILPVQPHDREEMKRILPRSEKIVFARGGSERQYSVRNGLELAGSCSVILVHDGARPFISAGSIAALAAMAGEKGAAIAAVPVKDTIKRAKDQIVTETIERSSLWQIQTPQAFRTSVLKKAHEAAERDGFLGTDEASLVERIGHPVHIVPGSYDNIKITTPEDLYFAEAILKKQGGG
>NC_016023.1|WP_014096525.1|1280806_1281892_-|PIN/TRAM-domain-containing-protein
MLLRRLIQICLVLIGGTLGVFLLPDFYKLVKVDYVLINNPYVSALLGAIIFYLITFWSIHYIVDFVDWFEDSLVKVPMTEIFSGTFGLVLGLIIAYLASIPVRGIPIVNTIVSITLTVLLGYIGFQVGFKKREEIFNLFFNRQHRRKGGTEQEGHPQPGKQVKILDTSVVIDGRIADICQTGFLDGPIVIPLFVLEELQHIADSSDALKRNRGRRGLDILNRIQNELPIEVQMYEGDFEDIQEVDSKLIKLAKLMNGIVVTNDYNLNKVCEFQKVKVLNINDLANAVKPVVLPGEELNVQLIKDGKEHHQGIAYLDDGTMIVVEEGKNYIGKRIDVLVTSVLQTSAGRMIFAKPKLLEKAL
>NC_016023.1|WP_014096526.1|1282238_1283609_-|DNA-repair-protein-RadA
MAKKTVKFVCQNCGYESPKWMGKCPQCSQWNQMVEEAETPKRRGFFLHPEPGNETKAAPITSIESKEEKRTKVDFGELNRVLGGGIVAGSLVLIGGDPGIGKSTLLLQVSSQLAKHGLNVLYISGEESAKQTKLRADRLNIHTDHLYVLPETDLSVIQQAIDELNPGFVVIDSIQTIYHPEIQSAPGSVSQVRETTAQLMRTAKTKNVAIFIVGHVTKEGSIAGPRVLEHMVDTVLYFEGERHNAYRILRAVKNRFGSTNEIAILEMKESGLEEVQNPSEIFLEERTKGAAGSTVVASIEGTRPVLVEIQALLAPTFFNMPRRMASGIDYNRVTLIMAVLEKRAGLLIQNQDAYLKVAGGLKVDEPAVDLAVAVSVASSFRDKPTNADDCIIGEVGLTGEVRRVSRIEQRVQEAAKLGFRRAIIPKNNMGGWTPPKEIQVIGVSTIQEALEAALGG
>NC_016023.1|WP_014096528.1|1283841_1286292_-|ATP-dependent-Clp-protease-ATP-binding-subunit
MMFGRFTERAQKVLALSQEEAIRLKHNNIGTEHILLGLVREGEGIAAKALYGLGLSAEKIQEEVETLIGNGQEISQTIHYTPRAKKVIELSMDEARKLGHSYVGTEHILLGLIREGEGVAARVLTNLGVSLNKARQQVLQLLGNSEASVQGGSAASVSTPTLDSLARDLTAIAREDSLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIAEGLAQQIVHNEVPETLRDKRVMTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIILFIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTLDEYRKYIEKDAALERRFQPIQVDEPTIDESIQILKGLRDRYEAHHRVSITDEAIEAAVKLSDRYIADRFLPDKAIDLIDEAGSKVRLRSFTTPPNLKELELKLEEVRKEKDAAVQSQEFEKAAALRDTEQKLREQLEETKKNWKAKQGQENSEVTVDDIALVVSSWTGVPVTKLAQTETERLLHLEEILHSRVIGQEEAVLAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAEAMFGDEDAMIRIDMSEYMEKHSTSRLVGSPPGYVGFEEGGQLTEKVRRKPYSVVLLDEIEKAHPDVFNILLQVLDDGRLTDSKGRTVDFSNTIVIMTSNVGADALKRNKSVGFTIQDTVEADYKDMKDKVLEELKKAFRPEFLNRVDETIVFHSLEKKQLNEIVTLMAKELSDRLKEHHIELVLTDAAKEKVAEKGYDPEYGARPLRRSIQKNIEDRLSEEMLKGNIKEGQKVLVDVKDGEFTFASVAESEAVSSNS
>NC_016023.1|WP_014096529.1|1286308_1287376_-|protein-arginine-kinase
MSLEHFLHKASSSWMNEQGPESEIVLTTRVRLARNLKNYRFPSLFTSEEAREIMKTIQDIARNHFPAEMQAEFLKMDELKPLEKRVLVEKHLISPQLAEEAGDGAVILSSGEDISIMINEEDHLRIQCLSPGLQLHETLQKANQLDDLLENWVDYAFDETLGYLTSCPTNVGTGIRASAMMHLPGLVLTQQIKQIIPAIHQLGLVVRGIYGEGSEAIGNIFQISNQVTLGTSEDNIVSDLTSVIRQIITQERSAREALVQTSNIQLEDRVYRSLGVLQNSRIIETKEAARCLSDVRLGIDLGYIQNISKQILNELMILMQPGFLQLYAGRALSPYERDIRRATLIRERLRLEETK
>NC_016023.1|WP_014096530.1|1287375_1287921_-|UvrB/UvrC-motif-containing-protein
MICQECNERPATMHFTKIINGVKTEFHLCEKCAQEKGEKFSSDWGKTFSFDNLLAGLFNFDPAIQLFKQETAPDPDVLRCNHCGMTLNQFLNTSRLGCPHCYETFQHQLVPILQRLHGGNVAHEGKIPARIGGAIYTKKKLQELKAALQEAISQEEFEKAAELRDQIRALEGSSQAKGGEQ
>NC_016023.1|WP_013858048.1|1287940_1288402_-|CtsR-family-transcriptional-regulator
MKNISDIIEEYLKRILELNEKEILEIKRNEIADKFQCVPSQINYVINTRFTIERGYIVESKRGGGGYIRIMKVRPESDAELIDQLLVHIGNVISQSNAEAIILRLVEEEVISRREAKIMLSVMDRSVLYIQLPERDELRARMLKSMLTTLKYK
>NC_016023.1|WP_100183740.1|1288691_1288949_-|DUF3969-family-protein
MLNVLGIIEAVYNKKISIEEAEKRYFNYRIIDSLKEKNYSNELIEILELGTEIDGINDLLPDKLDENIIDLKNRVLLLLDREIKA
>NC_016023.1|WP_014096533.1|1294958_1295225_-|pro-sigmaK-processing-inhibitor-BofA-family-protein
MSSTIIIIAIVGLILLLLFSAALTKPLRWAGKLCIKAIIGAILLFFLNQVGGRYGLHVPINAATVSVSGLLGIPGVIGLTVIQTWILS

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_016023_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016023_8

1418085-1418176

Orphan

Consensus_repeat	Method
TCGTAGTGCTTTTTTATTATATGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_016023_8

>merge|NC_016023|8|1418085-1418176|CRISPRCasFinder
TCGTAGTGCTTTTTTATTATATGGTTCACCTAACCCCCGATTTCGTGCCTGTTCAAGCTATGTAGCCCATCGAGTGCTTTTTTATTATATGG

>NC_016023|8|7|1418085-1418176|CRISPRCasFinder
TCGTAGTGCTTTTTTATTATATGG	TTCACCTAACCCCCGATTTCGTGCCTGTTCAAGCTATGTAGCCC
ATCGAGTGCTTTTTTATTATATGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_016023.1\|WP_014096625.1\|1414040_1414484_+\|50S-ribosomal-protein-L9	unknown	unknown	gnl\|CDD\|234659
NC_016023.1\|WP_014096619.1\|1407879_1409073_+\|bifunctional-3,4-dihydroxy-2-butanone-4-phosphate-synthase/GTP-cyclohydrolase-II	unknown	unknown	gnl\|CDD\|181774
NC_016023.1\|WP_014096622.1\|1410158_1410653_+\|single-stranded-DNA-binding-protein	unknown	unknown	gnl\|CDD\|168659
NC_016023.1\|WP_014096628.1\|1418501_1419212_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_016023.1\|WP_014096631.1\|1422303_1423086_+\|two-component-system-regulatory-protein-YycI	unknown	unknown	gnl\|CDD\|378229
NC_016023.1\|WP_014096624.1\|1412070_1414044_+\|DHH-family-phosphoesterase	unknown	unknown	gnl\|CDD\|226404
NC_016023.1\|WP_014096620.1\|1409085_1409556_+\|6,7-dimethyl-8-ribityllumazine-synthase	unknown	unknown	gnl\|CDD\|234606
NC_016023.1\|WP_014096629.1\|1419216_1421037_+\|cell-wall-metabolism-sensor-histidine-kinase-WalK	unknown	unknown	gnl\|CDD\|380161
NC_016023.1\|WP_013860872.1\|1423102_1423897_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|224156
NC_016023.1\|WP_014096626.1\|1414703_1416059_+\|replicative-DNA-helicase	unknown	unknown	gnl\|CDD\|180232
NC_016023.1\|WP_014096633.1\|1425675_1426155_+\|23S-rRNA-(pseudouridine(1915)-N(3))-methyltransferase-RlmH	unknown	unknown	gnl\|CDD\|376840
NC_016023.1\|WP_014096621.1\|1409809_1410097_+\|30S-ribosomal-protein-S6	unknown	unknown	gnl\|CDD\|179034
NC_016023.1\|WP_014096636.1\|1428106_1429591_+\|hypothetical-protein	unknown	unknown	unknown
NC_016023.1\|WP_014096634.1\|1426464_1427769_-\|IS1380-like-element-ISBco2-family-transposase	unknown	unknown	gnl\|CDD\|379340
NC_016023.1\|WP_013860883.1\|1410697_1410937_+\|30S-ribosomal-protein-S18	unknown	unknown	gnl\|CDD\|178997
NC_016023.1\|WP_014096635.1\|1427788_1428004_+\|hypothetical-protein	unknown	unknown	unknown
NC_016023.1\|WP_014096632.1\|1424114_1425377_+\|trypsin-like-peptidase-domain-containing-protein	unknown	unknown	gnl\|CDD\|273938
NC_016023.1\|WP_014096627.1\|1416233_1417523_+\|adenylosuccinate-synthase	unknown	unknown	gnl\|CDD\|234904
NC_016023.1\|WP_014096623.1\|1411093_1412035_+\|YybS-family-protein	unknown	unknown	gnl\|CDD\|370773
NC_016023.1\|WP_014096630.1\|1421033_1422317_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369363

Protein	Function_ID	Function_description	E-value
NC_016023.1\|WP_014096625.1\|1414040_1414484_+\|50S-ribosomal-protein-L9	gnl\|CDD\|234659	PRK00137, rplI, 50S ribosomal protein L9; Reviewed.	9.80627e-66
NC_016023.1\|WP_014096619.1\|1407879_1409073_+\|bifunctional-3,4-dihydroxy-2-butanone-4-phosphate-synthase/GTP-cyclohydrolase-II	gnl\|CDD\|181774	PRK09311, PRK09311, bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II.	0
NC_016023.1\|WP_014096622.1\|1410158_1410653_+\|single-stranded-DNA-binding-protein	gnl\|CDD\|168659	PRK06751, PRK06751, single-stranded DNA-binding protein; Provisional.	9.81725e-74
NC_016023.1\|WP_014096628.1\|1418501_1419212_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	4.68549e-100
NC_016023.1\|WP_014096631.1\|1422303_1423086_+\|two-component-system-regulatory-protein-YycI	gnl\|CDD\|378229	pfam09648, YycI, YycH protein. This domain is exclusively found in YycI proteins in the low GC content Gram positive species. These two domains share the same structural fold with domains two and three of YycH pfam07435. Both, YycH and YycI are always found in pair on the chromosome, downstream of the essential histidine kinase YycG. Additionally, both proteins share a function in regulating the YycG kinase with which they appear to form a ternary complex. Lastly, the two proteins always contain an N-terminal transmembrane helix and are localized to the periplasmic space as shown by PhoA fusion studies.	1.9002e-56
NC_016023.1\|WP_014096624.1\|1412070_1414044_+\|DHH-family-phosphoesterase	gnl\|CDD\|226404	COG3887, COG3887, Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms].	0
NC_016023.1\|WP_014096620.1\|1409085_1409556_+\|6,7-dimethyl-8-ribityllumazine-synthase	gnl\|CDD\|234606	PRK00061, ribH, 6,7-dimethyl-8-ribityllumazine synthase; Provisional.	6.10782e-87
NC_016023.1\|WP_014096629.1\|1419216_1421037_+\|cell-wall-metabolism-sensor-histidine-kinase-WalK	gnl\|CDD\|380161	NF033092, HK_WalK, cell wall metabolism sensor histidine kinase WalK. This model describes WalK as found in Staphylococcus aureus (sp\|Q2G2U4.1\|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.	0
NC_016023.1\|WP_013860872.1\|1423102_1423897_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|224156	COG1235, PhnP, Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only].	2.08062e-70
NC_016023.1\|WP_014096626.1\|1414703_1416059_+\|replicative-DNA-helicase	gnl\|CDD\|180232	PRK05748, PRK05748, replicative DNA helicase; Provisional.	0
NC_016023.1\|WP_014096633.1\|1425675_1426155_+\|23S-rRNA-(pseudouridine(1915)-N(3))-methyltransferase-RlmH	gnl\|CDD\|376840	pfam02590, SPOUT_MTase, Predicted SPOUT methyltransferase. This family of proteins are predicted to be SPOUT methyltransferases.	2.85809e-85
NC_016023.1\|WP_014096621.1\|1409809_1410097_+\|30S-ribosomal-protein-S6	gnl\|CDD\|179034	PRK00453, rpsF, 30S ribosomal protein S6; Reviewed.	1.01619e-40
NC_016023.1\|WP_014096634.1\|1426464_1427769_-\|IS1380-like-element-ISBco2-family-transposase	gnl\|CDD\|379340	pfam13701, DDE_Tnp_1_4, Transposase DDE domain group 1. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	3.59799e-49
NC_016023.1\|WP_013860883.1\|1410697_1410937_+\|30S-ribosomal-protein-S18	gnl\|CDD\|178997	PRK00391, rpsR, 30S ribosomal protein S18; Reviewed.	6.9465e-42
NC_016023.1\|WP_014096632.1\|1424114_1425377_+\|trypsin-like-peptidase-domain-containing-protein	gnl\|CDD\|273938	TIGR02037, Probable_periplasmic_serine_protease_do/HhoA-like, periplasmic serine protease, Do/DeqQ family. This family consists of a set proteins various designated DegP, heat shock protein HtrA, and protease DO. The ortholog in Pseudomonas aeruginosa is designated MucD and is found in an operon that controls mucoid phenotype. This family also includes the DegQ (HhoA) paralog in E. coli which can rescue a DegP mutant, but not the smaller DegS paralog, which cannot. Members of this family are located in the periplasm and have separable functions as both protease and chaperone. Members have a trypsin domain and two copies of a PDZ domain. This protein protects bacteria from thermal and other stresses and may be important for the survival of bacterial pathogens.// The chaperone function is dominant at low temperatures, whereas the proteolytic activity is turned on at elevated temperatures. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides].	3.60433e-93
NC_016023.1\|WP_014096627.1\|1416233_1417523_+\|adenylosuccinate-synthase	gnl\|CDD\|234904	PRK01117, PRK01117, adenylosuccinate synthetase; Provisional.	0
NC_016023.1\|WP_014096623.1\|1411093_1412035_+\|YybS-family-protein	gnl\|CDD\|370773	pfam09991, DUF2232, Predicted membrane protein (DUF2232). This family of bacterial proteins are multi-pass membrane proteins with up to 10 (2 x 4/5) transmembrane regions. The exact function of this potential pore molecule is not known, but in many instances it is associated with ABC-transporter-like domains, implying that it is part of a secretion system that uses energy.	6.06878e-44
NC_016023.1\|WP_014096630.1\|1421033_1422317_+\|hypothetical-protein	gnl\|CDD\|369363	pfam07435, YycH, YycH protein. This family contains the bacterial protein YycH which is approximately 450 residues long. YycH plays a role in signal transduction and is found immediately downstream of the essential histidine kinase YycG. YycG forms a two component system together with its cognate response regulator YycF. PhoA fusion studies have shown that YycH is transported across the cytoplasmic protein. It is postulated that YycH functions as an antagonist to YycG. The molecule is made up of three domains, and has a novel three-dimensional structure. The N-terminal domain features a calcium binding site and the central domain contains two conserved loop regions.	4.95066e-79

>NC_016023.1|WP_014096627.1|1416233_1417523_+|adenylosuccinate-synthase
MSSVVVVGTQWGDEGKGKITDFLSENAEVVSRYQGGNNAGHTIRFNGETYKLHLIPSGIFYKDKICVIGNGVVVDPKALVEELDYLNGRGISTENLRISNRAHVILPYHIKLDGAEEERKGSNKIGTTKKGIGPAYMDKAARTGIRIADLLDYEEFKEKLTRNLEEKNRLFEKIYETEGFTLEEILEPYYEYGQRFKQYVCDTSVVLNDALDAGKRVLFEGAQGVMLDIDQGTYPFVTSSNPIAGGVTIGSGVGPSKINHVVGIAKAYTTRVGDGPFPTELLDETGDRIRETGHEYGTTTGRARRVGWFDSVVVRHARRVSGLTDLSVNLLDVLTGIETLKICVAYRYKGKVLEAFPASLKVLAECEPVYEELPGWTEDITGCRSLDELPDNARHYLERISQLTGVPLSMFSVGPDRLQTIVVQSVWRV
>NC_016023.1|WP_014096626.1|1414703_1416059_+|replicative-DNA-helicase
MNELQDRIPPQNIEAEQAVLGAIFLEPSAFITASEILTAEDFYRNAHQKIFQVFAKLNDAGKAVDLVTVAEELSATRQLEDAGGLSYLSELAASVPTAANIAYYAGIVAEKALLRRLIRTATHIAQEGYTREDDVDELLDEAERSIMEVAQRKNAGDFKHIKDVLVSTYDNIEMLHNRKGDVTGIPTGFYELDRMTAGFQRNDLIIVAARPSVGKTAFALNIAQNVGTKTEENVAIFSLEMGAEQLVMRMLCAEGNIDAQRLRTGALTDEDWRKLTMAMGSLSNSGIYIDDTPGVRVTEIRSKCRRLKQEHGLGMVVIDYLQLIQGSARSRENRQQEVSEISRSLKALARELEVPVIALSQLSRGVEQRQDKRPMMSDIRESGSIEQDADIVAFLYREDYYEQDTENKNIIEIIIAKQRNGPVGTVQLAFIKEYNKFVNLERRFDDAPVPA
>NC_016023.1|WP_014096625.1|1414040_1414484_+|50S-ribosomal-protein-L9
MKVIFLKDVKGKGKKGDIKNVADGYAHNYLFKNGAAIEATPANLKSMEAQKRKEEKLAQEELEEAKKLKEKLENITVEIKAKSGQDGRLFGSVTSKQISEQLKKSFQIQVDKRKIELPDAIRTLGYTKVPVRLHHNVTAVLNVHVSE
>NC_016023.1|WP_014096624.1|1412070_1414044_+|DHH-family-phosphoesterase
MPSYYNKRFMRYPLYGLIAVSLILLGIIFFYHWWITAAGIVVLGALSYCAFYVEQRSSEEIERYISNLSYRVKRVGEEALMEMPIGIMLYNEDYIIEWTNPFMASCFNEDTLVGRSLYDVAEVLVPLIKQEMHSETISLNERKYRVVLKLEERLLYFFDITEQAEVEQLYEDERTVIAIIYLDNYDEVTQGMDDQSVSSLNSLVTSILNKWTMEFGLFFKRISSDKFIAVFNERILHELEDNKFSILDEVREATAKQNVALTLSIGVGAGVPSLPELGELAQSSLDIALGRGGDQVAIRQANGKVKFYGGKTNPVEKRTRVRARVISHALRELMMERDKVMIMGHKFPDMDAIGAAVGIRKVAEINQKDGYIILNPSETDTSVKRLLGEIKQYPDLYARFITPDEALEMATDDTLLVVVDTHKPSLVIDERIVRRIENVVVIDHHRRGEDFIKNPLLVYMEPYASSTSELVTELMEYQPKNGKINMLEATALLAGIIVDTKSFTLRTGSRTFDAASYLRAQGADTVLVQKFLKEDLRSYIQRAKLVETVKFPLNGIAVAKGKNDTIYSPVLMAQAADTILMMNGVDASFVIGRRSENEVGISARSLGSVNVQIIMETLDGGGHLSNAATQMKNITVDEAEEKLIQVIEEYMEGSQQS
>NC_016023.1|WP_014096623.1|1411093_1412035_+|YybS-family-protein
MKKTRMLTEGAMLAAVFGVMLLVALHVPVIRIIVLVFLPLPFILFCAKYSLRSILVFCLVCLLVSAIMGTVMAIPMAVFFVCIGFVMGYAIQRKKSKLFIYIATSLTFLAITIIGLFATLKFFHLNIIAENLKIMQQSIEQSKSLVNSLGEPQAYEDRFAQMADAASQMYSVYLPSLLLLSAFIAVFVLISVNFPIAKRFGVPVPSFPPFREMRLPGNILWYFILAMAANLLMRGDTGSFFAKAVLNLMLIFQILILLQGYAFISFVSHEKKWPKGLLAFAVILSIIFSPLLYLVMIFGIMDLGFDFRRMIQK
>NC_016023.1|WP_013860883.1|1410697_1410937_+|30S-ribosomal-protein-S18
MAGGRRGGRKRRKVCYFTANHITHIDYKDVDLLKKFISERGKILPRRVTGTSAKYQRKLTTAIKRARQMALLPYVAEDK
>NC_016023.1|WP_014096622.1|1410158_1410653_+|single-stranded-DNA-binding-protein
MLNRVVLVGRLTKDPDLRYTPSGVAVATFTLAVNRTFTNQQGEREADFINCVVWRKQAENVANYLKKGSLAGVDGRIQTRNYEAQDGRRVYVTEVVADSVQFLEPRSANQERGSSQNYGNNQGSAFPGYNQNQNQYQRNDSKPDEDPFSNDGQPIDISDDDLPF
>NC_016023.1|WP_014096621.1|1409809_1410097_+|30S-ribosomal-protein-S6
MRKYEIMYIIRPNIEDEAKKALVERFDNVLNNQGAEIIESKEWGKRRLAYEIQDFRDGYYHIINVNAEPVAVQEFDRLAKINGDIIRHIVVREEE
>NC_016023.1|WP_014096620.1|1409085_1409556_+|6,7-dimethyl-8-ribityllumazine-synthase
MGQIFEGNLVGTGLKIGMVAARFNEFITTRLVSGAKDALLRHGVKEEAIDLAWVPGAFEIPLAAKKMAETDKYDAVLALGAVIRGATPHFEYVSAEAAKGVAHASLSTETPVIFGILTTDTIEQAIERAGTKAGNKGWDAAVSAIEMANVIRKIEA
>NC_016023.1|WP_014096619.1|1407879_1409073_+|bifunctional-3,4-dihydroxy-2-butanone-4-phosphate-synthase/GTP-cyclohydrolase-II
MFHTIEEAVEDLKAGKVVIAVDDENRENEGDFIGLAEKATPEMINLMAKAGRGLICAPITAEKAQQLDLYPMARQNTDSHETAFTVSIDHAATRTGISAFERAKTVRHLAEDAVKAEDFHRPGHIFPLVAKAGGVLERSGHTEAAVDLAKLAGANPAGVICEIMNEDGTMARLPQLEEIAKNSGIKLVTIQSLIEYRKKHEKLIQKEAEITLPTRYGTFRAAGYKDLLSGGEHVALIKGEVSSEEPVLARIHSECLTGDCFGSLRCDCGPQLARSLARIEKEGRGVLVYMRQEGRGIGLLNKLKAYRLQEKGLDTVEANRRLGFPADMRDYCIAAQILKDLGATQVRLLTNNPDKVEALTRYGIRIAERVPVEIAPVRENEGYLRTKAEKMGHLLHI
>NC_016023.1|WP_014096628.1|1418501_1419212_+|response-regulator-transcription-factor
MDKKILVVDDEKPIADILQFNLTKEGYTVYCAYDGEEALEKVEEVQPDLIVLDIMLPKRDGMEVCREVRKKYNMPIIMVTAKDSEIDKVLGLELGADDYVTKPFSTRELIARVKANLRRHQQTPAAPGEEEESNEIAIGSLVIHPDAYVVSKRGETIELTHREFELLHYLAKHIGQVMTREHLLETVWGYDYYGDVRTVDVTVRRLREKVEDNPSHPEWIVTRRGVGYYLRNPEQE
>NC_016023.1|WP_014096629.1|1419216_1421037_+|cell-wall-metabolism-sensor-histidine-kinase-WalK
MNKVKFFQSIHFKFVLIYILLIVVAMEIIGVYFINKLENQLETNFKKSIYDQVNVLEYSIEDLLTKKQNQAADITLKVRKVLGDFKSTDVSEIRLIDAHSGVILGTSSNDQSIVGQKTTEDIVKSVRVTGQPEDQIYLDKQTGDRMWVLASPIKANGELIGIIYLVSKIETVYRQVQAINQIFMTGTVIAVLVTALLGIITARTISKPLSEIRKQAMAMARGNFARKVKVIGNDEIGQLAYSFNHMTKKLQEAQASTEGERRKLDSILTHMTDGVIATDRRGRIILINEPAAEMLDVSRETVLSQPLISVLKIENEHKFDDLLTEQDSVILDFSTEEEPYILRANFSVIQNEAGFVSGLITVLHDVTEQEKIDMERREFVANVSHELRTPLTTMRSYLEALTDGAWKDEKIAPQFLGVTQNETERMIRLVNDLLKLSKMDSKDEHLNKEWVNFVEFFHHVIDRFEMAKQQNVTFKRKLPNTEIFVEIDEDKMTQVLYNIISNALKYSPEGGQITFKLRELNEKIEVSISDQGVGIPKENVKKIFERFYRVDKARSRKLGGTGLGLAIAKEMVEMHGGSIWASSKEGKGTTIYFTLPYEPAQEDEWL
>NC_016023.1|WP_014096630.1|1421033_1422317_+|hypothetical-protein
MSLEKAKTIILTLLVLLSLLLTWLIWNNQPNYDLLNLKDLDNIAIAKEKKVPGIILPDKILYHENDGTTGTVHDGEISRVMNLLRTWTFDMSSSRLLQKKDLYNLMYGKNRIELDFPAPVPFSVYQSVLNFANKKVPDADFDHIVIELNKGTKNLNHVYFISTASNKVYEASTDQKSIQVFISKLNDNKSLYKPYTAFALSGPRRIYLPAGNPVVNQYKYATTDIEIDKFKKALFADPNFVKKVAGEYTNGISLLRTDESNKVLTFVNPGEDIGYSSDPNHLLTRAIDFINQHSGWTDQYQYFEINERENEVTFRLFKDGYPVFNDDGMAEIREYLGKSEIYKYVRPYFNLSLNLPLKPAAVKLPPAQDVIAGLQTNSSVQMNKVRDIAVGYRLQKDSDDILSLQPAWYYCEDGIWKMAGGDEDGLE
>NC_016023.1|WP_014096631.1|1422303_1423086_+|two-component-system-regulatory-protein-YycI
MDWSKTKTIFILVFLVLDIYLSCQLYFKHVKNQYEVIGSPTAEQSLKAANITFVNLPKGKAKRPYISAEEKVFTAKDLKKLKNQQAEIVNGYQLSSAFDKPVKLGTKIKTDQLEAVIQENMLYGSRYKLWNYDKDLNQAVFYETYNGKMIFNNKNAKLTVYLNDRNEIISYDQTYLTNIKIYREEEETLSAVKAVEALYKKGTLKPNSKVTKAELGYYTRVPELQVLVPTWHFTVKHGNETEQLFINAFEGQVNEMENAQ
>NC_016023.1|WP_013860872.1|1423102_1423897_+|MBL-fold-metallo-hydrolase
MGMQFSVLASGSTGNAIYVETEQHAFLVDAGLSGRQMEQLFGQIGRNIADLSGILVTHEHSDHIKGIGVLARKYQLPVYANDKTWSAMEGMIGEIPTDLKFSFGMESVQSFGSLEIESFGVSHDAAQPMFYIFHEGGKKLVIITDTGYVSDRMKGTISNADIFVFESNHDVEMLRMGRYPWSVKQRILSDVGHVSNEDAALAMGEVIGDRTKRIYLAHLSKDNNMKDLARLAVSQTLQEQGLAVGETFSLYDTDPKIPTALTAV
>NC_016023.1|WP_014096632.1|1424114_1425377_+|trypsin-like-peptidase-domain-containing-protein
MGYYDDQDGQRRGKENRRSGGKFGYFLSGLIGVIVGALVVALLFPNIFGKTNSDSSAVDSNSVANTSTSTAKTTKTVSLKVTTDITKAVEKTEKAVVGVSNIQKQSIWSDDMFGQDSKSSSSSSQEAGSGSGIIYKKAGDKAYVVTNYHVIEGANALEVTLSNGKKLSAKLVGGDKYTDLAVLQIDGSNVTTVAQFGDSDALKLGETVIAIGNPLGEEFAGSVTEGIVSGLNRTVPVDIDEDGTEDWQEEVIQTDAAINPGNSGGALVNISGQVVGINSMKISNESVEGIGFSIPINSAKPVIHQLETKGKITRPALGVGIVNVSDISAYQQKETLKLPANVTTGVVIGSVENGSPASKAGLKEFDVIYKLDDQKIDNTVELRKFLYEHKQPGDKVKVSVYRNGQPKTFTLTLGTASGSN
>NC_016023.1|WP_014096633.1|1425675_1426155_+|23S-rRNA-(pseudouridine(1915)-N(3))-methyltransferase-RlmH
MNISIVTVGKLKEKYLKQGIQEYLKRLSAYAKVEIIEVADEKAPEMLSPAEMELVKQKEGGRILAKISPDTYVINLAIDGKMKSSEELAGSLDRLATYGKSKIAFVIGGSLGLSQAVLKRGNESLSFSKMTFPHQLMRLILVEQIYRAFRIIRGEPYHK
>NC_016023.1|WP_014096634.1|1426464_1427769_-|IS1380-like-element-ISBco2-family-transposase
MNYIIPVSRIKYEFNLKNSTKFSGILPFLQFLERMKTQQTFRGFDCLKKDNAKFPLSKIFVYLIAGWMADCSRMFHFQSLQNDPLIRAFLGGKCPHYTLLSKDLLRLEKIEDAAIEFKERVMDIIEPWLDSDLILDFDSSVETVYGNQEGAKIGVNPHKPGRKSYHPLLVFEGKSHLCLNGVLRPGNVHSADNGIEFAEETYRLLSAQYLIRYARFDKGFGGENFYSYWEQQKINYAGKLKWTSRLKKYVENDNSPWIRYVDDELIVIEGKTVYYQATSWEKPRRVAVIRKADKYEEDQLQLFDFLWDYEAIVTTMDWEPMDIWRFYNQRACLENYIKESKYGFSMDKIPTDSFGANHMDLLIKLLAYNLFEIFKKDHCPAAFKSYTIRRFRREFIYSAGVLTSHSRRVSLNICETYAHKWAFRKMIQSVRMID
>NC_016023.1|WP_014096635.1|1427788_1428004_+|hypothetical-protein
MVIVFFQNQLYQRMGHFFILNYYFTFVIWDDVIKVEAVLREFTEGKESLFTKKEQEELGLTDENLEIEQIY
>NC_016023.1|WP_014096636.1|1428106_1429591_+|hypothetical-protein
MLERSKLSQHKFEKGKLIAPFNQHFQDLLKEESWYYGRMPEYVWLGLIVNDGDRNKQLDKCIRILNYIHELAESEKVDFPKLSLIFKLPDEKQKAIYEFMNKLQVLEPLRPLSLIFPDQSAEFSKAVKGYNIPIKNRIGILNEILEDLSDQHSNLTTDVRFLILYKFMLSGKFHVSTDSIFPEMISRYAYISHDDPEMAIYRPNIRATEMMVSTGVGEEESVNIEFVRDFWKRLSLLTDCEAFYVDTESKENKPINLKKYKQHVYEVLNYYTKLFTETRPLDNRMLVLLGIATYSYKRLIELVDHDLENTISGRTIMRSIIENYMMTKYLLLEEPNHDDIWGEYQDYGIGQYKMIYGRYADEGPKVEGSHVPFEYIKLLVSEFKNEEFIDIDTSYFGKGNIRKKFKDVNEEDLWKFYYDYDSIYEHGLWGAIRESSILKCNAPGHQYHGIPDIDNLQKLPSVAHDCIMIMNRHLKLLEEQFGLPEILQEGDQNE

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Crispr_ID: NC_016023_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016023_9

1490096-1490173

Orphan

Consensus_repeat	Method
CCAAATGTCCTTATAACGGGGATGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_016023_9

>merge|NC_016023|9|1490096-1490173|CRISPRCasFinder
CCAAATGTCCTTATAACGGGGATGAAGGACAAAAGGAGAATCGCCGGCGCCCCAAATGTCCTTCATAACGGGGATGAA

>NC_016023|9|8|1490096-1490173|CRISPRCasFinder
CCAAATGTCCTTATAACGGGGATGAA	GGACAAAAGGAGAATCGCCGGCGCCC
CAAATGTCCTTCATAACGGGGATGAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_016023.1\|WP_014096677.1\|1477982_1478645_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224922
NC_016023.1\|WP_014096682.1\|1484529_1485603_+\|branched-chain-amino-acid-aminotransferase	unknown	unknown	gnl\|CDD\|237363
NC_016023.1\|WP_014096681.1\|1482387_1484190_+\|carbon-starvation-protein-A	unknown	unknown	gnl\|CDD\|224877
NC_016023.1\|WP_014096689.1\|1493687_1494629_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176129
NC_016023.1\|WP_014096687.1\|1490324_1491338_-\|DUF1646-family-protein	unknown	unknown	gnl\|CDD\|285138
NC_016023.1\|WP_014096693.1\|1497852_1499121_+\|two-component-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NC_016023.1\|WP_014096680.1\|1481540_1482257_+\|LytTR-family-transcriptional-regulator-DNA-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|184495
NC_016023.1\|WP_014096688.1\|1491691_1493539_+\|asparagine-synthase-(glutamine-hydrolyzing)	unknown	unknown	gnl\|CDD\|273676
NC_016023.1\|WP_041819784.1\|1496131_1496593_+\|Cys-tRNA(Pro)-deacylase	unknown	unknown	gnl\|CDD\|237976
NC_016023.1\|WP_014096675.1\|1475910_1476690_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224044
NC_016023.1\|WP_014096690.1\|1494731_1495109_+\|CidA/LrgA-family-holin-like-protein	unknown	unknown	gnl\|CDD\|167253
NC_016023.1\|WP_013860807.1\|1496606_1497044_-\|DUF2231-domain-containing-protein	unknown	unknown	gnl\|CDD\|226695
NC_016023.1\|WP_014096678.1\|1478706_1479549_+\|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224381
NC_016023.1\|WP_013860806.1\|1497191_1497869_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_016023.1\|WP_013860809.1\|1495851_1495998_+\|hypothetical-protein	unknown	unknown	unknown
NC_016023.1\|WP_014096679.1\|1479784_1481566_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|225814
NC_016023.1\|WP_014096676.1\|1476952_1477993_+\|methionine-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|236863
NC_016023.1\|WP_014096684.1\|1486881_1487328_+\|threonine/serine-exporter-family-protein	unknown	unknown	gnl\|CDD\|378960
NC_016023.1\|WP_014096683.1\|1486056_1486806_+\|threonine/serine-exporter-family-protein	unknown	unknown	gnl\|CDD\|377697
NC_016023.1\|WP_014096691.1\|1495098_1495782_+\|LrgB-family-protein	unknown	unknown	gnl\|CDD\|377236

Protein	Function_ID	Function_description	E-value
NC_016023.1\|WP_014096677.1\|1477982_1478645_+\|ABC-transporter-permease	gnl\|CDD\|224922	COG2011, AbcD, ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism].	1.63809e-93
NC_016023.1\|WP_014096682.1\|1484529_1485603_+\|branched-chain-amino-acid-aminotransferase	gnl\|CDD\|237363	PRK13357, PRK13357, branched-chain amino acid aminotransferase; Provisional.	0
NC_016023.1\|WP_014096681.1\|1482387_1484190_+\|carbon-starvation-protein-A	gnl\|CDD\|224877	COG1966, CstA, Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms].	0
NC_016023.1\|WP_014096689.1\|1493687_1494629_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176129	cd08438, PBP2_CidR, The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold. This CD includes the substrate binding domain of CidR which positively up-regulates the expression of cidABC operon in the presence of acetic acid produced by the metabolism of excess glucose. The CidR affects the control of murein hydrolase activity by enhancing cidABC expression in the presence of acetic acid. Thus, up-regulation of cidABC expression results in increased murein hydrolase activity. This substrate binding domain has significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	9.63672e-88
NC_016023.1\|WP_014096687.1\|1490324_1491338_-\|DUF1646-family-protein	gnl\|CDD\|285138	pfam07854, DUF1646, Protein of unknown function (DUF1646). Some of the members of this family are hypothetical bacterial and archaeal proteins, but others are annotated as being cation transporters expressed by the archaebacterium Methanosarcina mazei.	2.51026e-97
NC_016023.1\|WP_014096693.1\|1497852_1499121_+\|two-component-sensor-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.69955e-53
NC_016023.1\|WP_014096680.1\|1481540_1482257_+\|LytTR-family-transcriptional-regulator-DNA-binding-domain-containing-protein	gnl\|CDD\|184495	PRK14084, PRK14084, DNA-binding response regulator.	3.4838e-63
NC_016023.1\|WP_014096688.1\|1491691_1493539_+\|asparagine-synthase-(glutamine-hydrolyzing)	gnl\|CDD\|273676	TIGR01536, Asparagine_synthetase_1, asparagine synthase (glutamine-hydrolyzing). This model describes the glutamine-hydrolysing asparagine synthase. A poorly conserved C-terminal extension was removed from the model. Bacterial members of the family tend to have a long, poorly conserved insert lacking from archaeal and eukaryotic sequences. Multiple isozymes have been demonstrated, such as in Bacillus subtilis. Long-branch members of the phylogenetic tree (which typically were also second or third candidate members from their genomes) were removed from the seed alignment and score below trusted cutoff. [Amino acid biosynthesis, Aspartate family].	0
NC_016023.1\|WP_041819784.1\|1496131_1496593_+\|Cys-tRNA(Pro)-deacylase	gnl\|CDD\|237976	cd00002, YbaK_deacylase, This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS) inserted (INS) editing domain. The bacterial amino acid trans-editing enzyme YbaK is a deacylase that hydrolyzes cysteinyl-tRNA(Pro)'s mischarged by prolyl-tRNA synthetase. YbaK also hydrolyzes glycyl-tRNA's, alanyl-tRNA's, seryl-tRNA's, and prolyl-tRNA's. YbaK is homologous to the INS domain of prolyl-tRNA synthetase (ProRS) as well as the trans-editing enzyme ProX of Aeropyrum pernix which hydrolyzes alanyl-tRNA's and glycyl-tRNA's.	1.11172e-74
NC_016023.1\|WP_014096675.1\|1475910_1476690_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224044	COG1119, ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism].	1.29063e-98
NC_016023.1\|WP_014096690.1\|1494731_1495109_+\|CidA/LrgA-family-holin-like-protein	gnl\|CDD\|167253	PRK01658, PRK01658, CidA/LrgA family holin-like protein.	3.80396e-27
NC_016023.1\|WP_013860807.1\|1496606_1497044_-\|DUF2231-domain-containing-protein	gnl\|CDD\|226695	COG4244, COG4244, Predicted membrane protein [Function unknown].	3.84669e-13
NC_016023.1\|WP_014096678.1\|1478706_1479549_+\|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein	gnl\|CDD\|224381	COG1464, NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism].	9.66105e-109
NC_016023.1\|WP_013860806.1\|1497191_1497869_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	9.1574e-75
NC_016023.1\|WP_014096679.1\|1479784_1481566_+\|sensor-histidine-kinase	gnl\|CDD\|225814	COG3275, LytS, Putative regulator of cell autolysis [Signal transduction mechanisms].	0
NC_016023.1\|WP_014096676.1\|1476952_1477993_+\|methionine-ABC-transporter-ATP-binding-protein	gnl\|CDD\|236863	PRK11153, metN, DL-methionine transporter ATP-binding subunit; Provisional.	0
NC_016023.1\|WP_014096684.1\|1486881_1487328_+\|threonine/serine-exporter-family-protein	gnl\|CDD\|378960	pfam12821, ThrE_2, Threonine/Serine exporter, ThrE. ThrE_2 is a family of membrane proteins involved in the export of threonine and serine. L-threonine, L-serine are both substrates for the exporter. The exporter exhibits nine-ten predicted transmembrane-spanning helices with long charged C and N termini and an amphipathic helix present within the N-terminus. L-Threonine can be made by the amino acid-producing bacterium Corynebacterium glutamicum, but the potential for amino acid formation can be considerably improved by reducing its intracellular degradation into glycine and increasing its export by this exporter. Members of the family are found in Bacteria, Archaea, and the fungal kingdoms, and the family can exist either as a single long polypeptide chain or as two short polypeptides. All family members show an extended hydrophilic N-terminal domain with weak sequence similarity to portions of hydrolases (proteases, peptidases, and glycosidases); this suggests that since this region is cytoplasmic to the membrane it may be generating the transport substrate, so may imply that threonine may not be the primary substrate and the ThrE has a subsidiary function.	1.33921e-38
NC_016023.1\|WP_014096683.1\|1486056_1486806_+\|threonine/serine-exporter-family-protein	gnl\|CDD\|377697	pfam06738, ThrE, Putative threonine/serine exporter. ThrE is a family of bacterial and Archaeal proteins that catalyze the export of L-threonine from the cell. UniProtKB:Q79VD1 has been characterized as being necessary for this export. The domain exhibits 10 putative TMs and catalyzes the proton-motive-force-dependent efflux of threonine and serine.	5.933e-84
NC_016023.1\|WP_014096691.1\|1495098_1495782_+\|LrgB-family-protein	gnl\|CDD\|377236	pfam04172, LrgB, LrgB-like family. The two products of the lrgAB operon are potential membrane proteins, and LrgA and LrgB are both thought to control of murein hydrolase activity and penicillin tolerance.	1.24236e-74

>NC_016023.1|WP_014096684.1|1486881_1487328_+|threonine/serine-exporter-family-protein
MFQQLLTSFFASAGFGILFNAPRKLLIQCGITGMIGWGIYFLFYMYEQNVVYGTFIAAFFVGVISQVFARFYKTPILIFTVGGIIPLVPGGLAYDAMRHFVQNDYNGAVSLAAKVLLLSIAIAIGLVASEVANQFIKKLPDRRPKRMK
>NC_016023.1|WP_014096683.1|1486056_1486806_+|threonine/serine-exporter-family-protein
MYQNEAQQVMRVCLLAGKIMLMSGAETYRVEDTMSRIAAAAGISGSHSFVTPTAIIFSLDGAELTKLIRISERSTDLRKVDQVNSISRQISNRGITLKEAYGQLKKIETEEEAYPLWLQFVAAAISSGCFVIIFLGGWIDFLPACIAGGLGFLSTHYIHRFVKVRFFAEFVASLVIGITAYILVHAGIGRELDKIIIGSVMPLVPGLAITNALRDLMAGHLFSGVTKGAEAFLTSFAIGSGIAIILTIF
>NC_016023.1|WP_014096682.1|1484529_1485603_+|branched-chain-amino-acid-aminotransferase
MNQVIEFVKADVKKEKPAVESLGFGKHFTDYMFVMDYNEEEGWHQPRITPYAPLVLEPAAMVFHYSQSVFEGLKAYRAKDGRVLLFRPEKNVARMNVSCARLSIPQIDETIVLDAIKQLVELEKDWIPDGEGTSLYIRPFIIATEPSLGVHPAHEYKFMIILSPVGSYYGDQLKPVRIYVEDEYVRAVPGGVGFTKTGGNYAASLKAQEKAEELGYDQVLWLDGVERKYIEEVGSMNIFFKINGEVVTPKLNGSILGGVTRDSVIELLKYWNVPVKETKISIDEIYNAYKNGQLEEVFGTGTAAVISPVGELGWKDVAMQLPHAEAPDSIANRLYDALTGIQLGKTEDPLNWTVEIK
>NC_016023.1|WP_014096681.1|1482387_1484190_+|carbon-starvation-protein-A
MNAITIVIGSICILMIAYRLYGTFMAVKVLKLNNDTPTPAHEFNDGKDYVPTNKWVTFGHHFAAIAAAGPLVGPILAAQFGYLPGLLWLLIGAVIGGAVHDAVVLFASMRRKGKSLSEVAKEEMGPVAGFCTGLAMLFIIVITMAGLSMVVVNALQNNPWGTFSVGITIPVAMGVGLFYKKTGNLKLTTTIGFLLIVAGVFAGPWIRHTVIGEWLTFDPKTLAIILPAYAFFAAALPVWLLLAPRDYLSSFMKIGVFIALIIGVFIINPPIHMPALSQFIHGGGPTMTGPVWPFISITIACGAISGFHAFIGSGTTPKMLDKWTDIKPVAFGAMLVESLVGVMALVAATALQPADYFAINSTPEVFKTLGMHVVNLPHLSSEIGMDLAGRTGGAVTLAVGMTYIFTKIHWFSNLAPYFYQFVILFEAVFILTAIDSGTRVARYLLQDFLGELYKPLKKTDWLPGSILTSAAACFMWGYLLYSGDIGSVWALFGVSNQLMASIGLIVGATVILKIADKKRYMFTCLIPLAYLYVTVNYAGYWMVKNVYLNHAAAGYNVLNGILSIIMLILGIVIMISALKNWYDLLRTPAMPDLEVSARKA
>NC_016023.1|WP_014096680.1|1481540_1482257_+|LytTR-family-transcriptional-regulator-DNA-binding-domain-containing-protein
MLKAFVVDDEAPARDELIYLLKKTGQVELAGEAGSVKEALAKLKETEADIVFVDMMLTNEHGIDLVKEISRHPQHPAVVFATAYDEYAVKAFELNAADYILKPFEEKRVAQTVAKVKKMLEGDRPAVPKNPGKLAVTTDERIVIIPVEKLLYAESVDGRTVIATDDKKYTITESLVNVEKKLPSTSIARVHRAYLVNLDGIVEIRPWFHSTYNLIMRDGAKIPVSRTYKHVLKQFIRI
>NC_016023.1|WP_014096679.1|1479784_1481566_+|sensor-histidine-kinase
MATLLPVMLERAGILVIAAFLLSRLKTFRQIIHQEYGRKEKLVLIIVFGIFGIISNYTGIVIEHGKVSHAFGQGHLSVESAIANTRIMGVGIAGLLGGPVVGIGAGLLASIHRLSLGGYTDIACSLSTMIAGIIMGFIGRRFNVRGKYAALEAVAAGVLMEMLQMGIILAVAKPFEEAVALVRLIAVPMISINGFGTFIFILIIQTILLEEERTRAVQTHKALQIAQETLVHFRKGLNMESCKEAAEIILKHTAADAVAITDREKVLTHAGVASDHHIPLESMSTKLTERVLLHGKIMVARTAKEIQCNHEGCPLQAAIVLPLFVREQVAGTLKLYFTSASQLSAVEQELAEGLSKLFSNQLELAEAELQRKLLKDAEIKALQAQVHPHFFFNAINTITCLVRTDADKARELLVQLAAFFRSNLQGAGKMLIPLEKELEHVKAYLAIEQARFPGRYHVHFDIDPLLHTAMVPPFTLQPLVENAVRHAFTQQFTKNPYIVVRARVKSGKFIMETEDNGKGISKEQVQSLGNVAVDSAEGTGTALWNIRKRIEEIYGHSAVFRIENRKTGGTKVAISIPLEEIWGGEYAEGICSG
>NC_016023.1|WP_014096678.1|1478706_1479549_+|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein
MKKFAILLLGLILVLAGCGAKNNSSSTSTKTIKVGTTTSEVPTWNLIQKLAKKKNINIKIVRFDDYVQPNLALSDGEIDINAFQTVVYFDDFIKQRNLKLSAIGTTNIWPMGIYSKRYKKVSEVKDGDQVVIPKDPTNLGRALLLLQKAGLITTKKGFTGKGGLENVASNPKHLKITAVDAAQTPRGLDDSALAVINCDMAINAGLNPTNDSIFREDAGNKAYINIIAARTKDKNDKTLKEIVNIYHSKEVSDFIKKHYKGAAVPVNKPVSYLKDYKQTQ
>NC_016023.1|WP_014096677.1|1477982_1478645_+|ABC-transporter-permease
MAFDWSWFWPQFFTAMGQTLYMVAVSLLISIIIGIPVGVILVITRENGIWENKWIFNILNVIINIFRSIPFIILVVAIIPFTRWVVGTAIGTTAAIVPLVLYTAFYIGRLIESSLLEVDKGTIELAQSMGATNWQIIWRFLLPEAKASMVLNLTIATIGLIGASAMAGAVGAGGIGDLAITYGYNQFQTGVMIVTVITLVIFTQLVQTLGNFLSKKIRRK
>NC_016023.1|WP_014096676.1|1476952_1477993_+|methionine-ABC-transporter-ATP-binding-protein
MLVLEDIHKVYGKGKDKKVEALKGINLRVEKGEIFGVVGYSGAGKSTLIRCVNLLERPTSGKVLVNGVDLVRLPPAKLRQERKKIGMIFQQFNLLQSKTIFQNVAMPLVLEHRPKEEIKAKVAELLSFVGLEERMHHYPDQLSGGQKQRVGIARALATDPDILLCDEATSALDPNTTEAVLDLLRKVRDELGITILMITHEMNVIRDICDKVAVLDGGKIVEQGPVIDLFTEPKTQIARSFVKTVLNDSIPPSVQKLIDESSKDNPHGIYRILFKGASTNMPLLSNTAKQFSIDLNVLHGMITELQGIPFGNLLVELKGDPEEMKRAIQYINDHEAIIREVEKNGI
>NC_016023.1|WP_014096675.1|1475910_1476690_+|ABC-transporter-ATP-binding-protein
MENIIEVAGVSLMRDGKKLLSDIHWTVKKGEHWAVLGLNGSGKTTLLNMINGYIWPTKGSIKVLGKAFGKTSLPELRKSIGWVSSSIQERIPRTQLARDVVISGKYASIGLYEAVDAQDEEKALRLMEQLHCASLFSRAYEHCSQGERQKLLIARALMAEPRILILDEPCNGLDLFAREILLESVEELAKDKNGPTLVYVTHHPEEISPVFQKTLLIRNGEVFRQGRTSEMIEKQVLSRFFEHEIHVEWRGNRALFQVV
>NC_016023.1|WP_014096687.1|1490324_1491338_-|DUF1646-family-protein
MISALIIILALVLLLPFFVPFVERNLEIFLFIMGWAAAIAGGVLDKPLLRKALEDPVNITIAVFVAGLLFRWLERPLEKVISAINRGIPFPLLAALTVIILGLLSSVITAIIAALILVVIVSVLRLDRKSETQLVVYSCFSIGLGAALTPIGEPLSTLAISKLGEDFFYLLRLIGPEVISAVVIFGILAAIVIKPEQSAIGLKTAHKRESYVEIAGRTVKIYLFVMGLTLLGAGFEPLINRFLLDLSPFILYWINMISAVLDNATLAAAEISPKMADKTVQAILLGLLISGGMLVPGNIPNIISAGKLRITSREWARFGLPIGLAAMAVYFVVILFV
>NC_016023.1|WP_014096688.1|1491691_1493539_+|asparagine-synthase-(glutamine-hydrolyzing)
MCGITGWVDFQKDLRSELETVKKMTETLTKRGPDDTNYWLSPHAAFGHKRLVVVDPLCGVQPMTRQKDGKMYTICYNGELYNTEDLRAELLKKGYTYQGHSDTEVLLTAYIEWKEACVDRLNGIFAFVVWDGNKEQVFAARDRLGVKPFFYKAHGSGLLFGSEVKAMLAHPDVKAEVDEAGLAEIWGLGPSRTPGTGIFRGMAELRPAHALKMDRNGLKVWRYWNVKSAPHTEAAEETAETIRLLIQDAIVRQLVSDVPVCTFLSGGVDSSAITAIAAGHFQREGKGRLHTFSIDYEGNDRYFKANDFQPDADGVFIRKMSEAFDTVHHHCVITQEELAESLKAAVLARDVPGMADVDSSLLWFCREIKKDFTVSLSGECADEIFGGYPWFRREDDLNREGFPWMRSLDERIGLLKEGWQEKLQLKDYVMSKYEASVAETPLLDGETDLEKKRRQLFYINMLWFMTTLLDRKDRMSMGASLEVRVPFADHRIVEYVWNIPWEMKMYGGREKGILRKALEGILPEEILYRKKSPYPKTHHPAYTAAVKRWLGEVLEQKDSILYEFLHRDQLMELMETDGKAFRTPWFGQLMTGPQLLAYLAQIHYWFETYRIDIKA
>NC_016023.1|WP_014096689.1|1493687_1494629_-|LysR-family-transcriptional-regulator
MDIQHLQYFVSVATHGSFTKAARECYVSQPTISKMIKSFEEELGVPLFNRAGKKIVLTDAGQAVFQQAQKTLKAFRQLTDAINDVAGLKKGKIRIGLPPMIGSRYFPRVIDEFHHAYPDIKIQLVEDVTRKVVRDVENGTLDLGAVVMPVDDEVFGHFSFVHDRLVLLVHPSHRFAGCSSVRLKQLKEEEFIFFHRDFALHDQIIKECLKLGFMPNIIYESTQWDLICELVASNLGVALLPSTICHAFNPERVKIIHLEEPVLPWNLAIIWPKHQYLSFAVKEWIRFTKHLFGRGIPPAVPQPEEAMKKESEK
>NC_016023.1|WP_014096690.1|1494731_1495109_+|CidA/LrgA-family-holin-like-protein
MKKVLIGMLQIVGLYLFAEVMGAAAKLLHIPLPGSMLAMIALFLLLQFGIVKMGWIEIGANFLMAELLLFFIPSAVGMVKYRNLLVHNGPEILVVILISLIAAMACSGWLADKIANRRSVKMRDR
>NC_016023.1|WP_014096691.1|1495098_1495782_+|LrgB-family-protein
MIVKIVCLLLTVGSYWIFKKLYGKYKKIFVSPLLVTPVLLGAFLLGEDIPYRDYQKGTSVLTDLLQPAIVAFAVPLYRHFKIVRQYAVEILIGIGAGWLMAVFLSSAIATLFHFSKSLEHSIIPFTITTPIAMGVSEKIGGVPSITAVFVILNAIIGSVMAPWLIKHLRIKNEIAHGILLGTHANGIGTSKAFELSARSGAISSVSMIIVAAISIFVTPWMVSHIIH
>NC_016023.1|WP_013860809.1|1495851_1495998_+|hypothetical-protein
MGRQKYGNQNAERNKNAKLGNEVAEELVEFSTGRKDEIDQKKKKGVRK
>NC_016023.1|WP_041819784.1|1496131_1496593_+|Cys-tRNA(Pro)-deacylase
MRLLDAQKIPYGMLSYEVKDGKIDGISVAAKIGKPPEAVYKTLVTQGHSGELYVFVIPVAAELDLKKAAKAAGEKKIEMIHVKDIQKYTGYIRGGCSPIGMKKHYVTFVDESAATLDEIVVSAGKIGTQITLSPQGLLEAAHARYAALTQETR
>NC_016023.1|WP_013860807.1|1496606_1497044_-|DUF2231-domain-containing-protein
MGTPIHPLLVHFPIALLIFGVIFQFVALWKKEFFNKMALYLFGSGFVMGIASYMTGDSAIPDAREKWGQAVHSMVETHEHYALITMAIFGAVLFFKLLARFKPYKWIMPLVLVLCIAGTTTLALTGHYGGKMVYNMPGETSAPAK
>NC_016023.1|WP_013860806.1|1497191_1497869_+|response-regulator-transcription-factor
MKILLAEDDRRFGKLLHHMLEKEKHQVAWEQDGERAYDEAVFGSYDMLVLDWMMPGLEGIEICRKLRRQGFQGGIIMVTARDAVDDVVAGLRAGADDYIVKPFAFDELVARIDALGRRKLKTYQETITCAYLALHLESKQAEANGKMIPLTRQEYQLCEYFMRNKNLVLPREKIIEHIWGLDEDISDNALDALVKRVRKKIDREGERSLIETVRGLGYRMNDGHV
>NC_016023.1|WP_014096693.1|1497852_1499121_+|two-component-sensor-histidine-kinase
MMAMFKPIRKNLTIVYILTFFLFLIFILAVMYVTVQKVAEREQAREIRQYMKQEAAISKSGIARLKGKPAEKVKEADHPYFYYIFKPDGTLLKGEELIPGFHTKMKKFVTEKSSPSGMYETEYKERHAMYHAGMRTVPGIGRVYTVIGIETTGAHLVLKKLLLLFLFLAAVFTGVLALLSYFLAGKAIVPIQQAFDKQRKFVSDASHELRTPVSVFYSSAELLEREEGENLSAFGRGIVADLKTEAKLMAAMLDDLLFLARSDQNVQPYRFEEVGLYDLCTSIARRFQSGLPEEILLVNNLQDCPVVWGDPTRLQELVYIFLENARQYTEKGFIKLSLYKRGSFAAIEIADSGIGIDAHDLPRIFERFYRGDKARVRDGTGLGLSIAETIAKKHGGRIEVESKPGEGTIFTIFIPLKEVHHG

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Crispr_ID: NC_016023_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016023_10

1855983-1856078

Orphan

Consensus_repeat	Method
GATTTGTGTCGCCCTATATTGTCGAAAAAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_016023_10

>merge|NC_016023|10|1855983-1856078|CRISPRCasFinder
GATTTGTGTCGCCCTATATTGTCGAAAAATCTGATGCACGCCCCCAACATTTTTGCCGCCTGCGTCGATTTGTGTCTCCCTATATTGTCGAAAAAT

>NC_016023|10|9|1855983-1856078|CRISPRCasFinder
GATTTGTGTCGCCCTATATTGTCGAAAAAT	CTGATGCACGCCCCCAACATTTTTGCCGCCTGCGTC
GATTTGTGTCTCCCTATATTGTCGAAAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_016023.1\|WP_014097008.1\|1865775_1866354_+\|HAD-IA-family-hydrolase	unknown	unknown	gnl\|CDD\|319825
NC_016023.1\|WP_014097006.1\|1862335_1863757_+\|C40-family-peptidase	unknown	unknown	gnl\|CDD\|366353
NC_016023.1\|WP_014097011.1\|1868970_1870833_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_016023.1\|WP_014097010.1\|1867241_1868996_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_016023.1\|WP_014096999.1\|1855482_1855728_+\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|143421
NC_016023.1\|WP_014096994.1\|1849550_1851335_+\|DUF2357-domain-containing-protein	unknown	unknown	gnl\|CDD\|286861
NC_016023.1\|WP_014096996.1\|1852877_1853138_-\|hypothetical-protein	unknown	unknown	unknown
NC_016023.1\|WP_088775945.1\|1844713_1846258_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|143598
NC_016023.1\|WP_014096998.1\|1854392_1855055_+\|tellurium-resistance-protein-TerC	unknown	unknown	gnl\|CDD\|163429
NC_016023.1\|WP_014097004.1\|1860556_1861156_+\|DUF3237-family-protein	unknown	unknown	gnl\|CDD\|179149
NC_016023.1\|WP_014097012.1\|1870885_1871299_-\|hypothetical-protein	unknown	unknown	unknown
NC_016023.1\|WP_014097003.1\|1858702_1860175_+\|carboxylesterase/lipase-family-protein	unknown	unknown	gnl\|CDD\|225181
NC_016023.1\|WP_014096993.1\|1847539_1849567_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|224319
NC_016023.1\|WP_041818023.1\|1861115_1861964_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379258
NC_016023.1\|WP_014097009.1\|1866741_1867200_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NC_016023.1\|WP_017552300.1\|1854040_1854175_+\|hypothetical-protein	unknown	unknown	unknown
NC_016023.1\|WP_014096997.1\|1853448_1853841_+\|hypothetical-protein	unknown	unknown	unknown
NC_016023.1\|WP_014096995.1\|1851575_1852490_-\|AEC-family-transporter	unknown	unknown	gnl\|CDD\|223751
NC_016023.1\|WP_014096992.1\|1846463_1847540_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|370703
NC_016023.1\|WP_014097002.1\|1857180_1858650_+\|amidase-family-protein	unknown	unknown	gnl\|CDD\|236029

Protein	Function_ID	Function_description	E-value
NC_016023.1\|WP_014097008.1\|1865775_1866354_+\|HAD-IA-family-hydrolase	gnl\|CDD\|319825	cd07523, HAD_YsbA-like, uncharacterized family of the haloacid dehalogenase-like superfamily, similar to the uncharacterized Lactococcus lactis YsbA. The specific function of Lactococcus lactis YsbA is unknown. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.13622e-62
NC_016023.1\|WP_014097006.1\|1862335_1863757_+\|C40-family-peptidase	gnl\|CDD\|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	6.14167e-33
NC_016023.1\|WP_014097011.1\|1868970_1870833_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	0
NC_016023.1\|WP_014097010.1\|1867241_1868996_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	4.74313e-164
NC_016023.1\|WP_014096999.1\|1855482_1855728_+\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|143421	cd07103, ALDH_F5_SSADH_GabD, Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like. Succinate-semialdehyde dehydrogenase, mitochondrial (SSADH, GabD, EC=1.2.1.24) catalyzes the NAD+-dependent oxidation of succinate semialdehyde (SSA) to succinate. This group includes the human aldehyde dehydrogenase family 5 member A1 (ALDH5A1) which is a mitochondrial homotetramer that converts SSA to succinate in the last step of 4-aminobutyric acid (GABA) catabolism. This CD also includes the Arabidopsis SSADH gene product ALDH5F1. Mutations in this gene result in the accumulation of H2O2, suggesting a role in plant defense against the environmental stress of elevated reactive oxygen species.	3.79342e-39
NC_016023.1\|WP_014096994.1\|1849550_1851335_+\|DUF2357-domain-containing-protein	gnl\|CDD\|286861	pfam09823, DUF2357, Domain of unknown function (DUF2357). This entry was previously the N terminal portion of DUF524 (pfam04411) before it was split into two. This domain has no known function. It is predicted to adopt an all beta secondary structure pattern followed by mainly alpha-helical structures.	1.13338e-10
NC_016023.1\|WP_088775945.1\|1844713_1846258_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|143598	cd07574, nitrilase_Rim1_like, Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases). Some members of this subgroup are implicated in post-translational modification, as they contain an N-terminal GCN5-related N-acetyltransferase (GNAT) protein RimI family domain. The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), this subgroup corresponds to class 12. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer.	2.49636e-162
NC_016023.1\|WP_014096998.1\|1854392_1855055_+\|tellurium-resistance-protein-TerC	gnl\|CDD\|163429	TIGR03717, R_switched_YjbE, integral membrane protein, YjbE family. Rfam model RF00080 describes a structured RNA element called the yybP-ykoY leader, or SraF, which may precede one or several genes in a genome. Members of this highly hydrophobic protein family commonly are preceded by a yybP-ykoY leader, which may serve as a riboswitch. From the larger group of TerC homologs (pfam03741), this subfamily contains protein YjbE from Bacillus subtilis. A transport function is proposed.	2.8083e-05
NC_016023.1\|WP_014097004.1\|1860556_1861156_+\|DUF3237-family-protein	gnl\|CDD\|179149	PRK00872, PRK00872, hypothetical protein; Provisional.	4.15171e-44
NC_016023.1\|WP_014096993.1\|1847539_1849567_+\|AAA-family-ATPase	gnl\|CDD\|224319	COG1401, McrB, GTPase subunit of restriction endonuclease [Defense mechanisms].	7.06729e-09
NC_016023.1\|WP_041818023.1\|1861115_1861964_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379258	pfam13556, HTH_30, PucR C-terminal helix-turn-helix domain. This helix-turn-helix domain is often found at the C-terminus of PucR-like transcriptional regulators such as Bacillus subtilis pucR and is likely to be DNA-binding.	1.62712e-16
NC_016023.1\|WP_014097003.1\|1858702_1860175_+\|carboxylesterase/lipase-family-protein	gnl\|CDD\|225181	COG2272, PnbA, Carboxylesterase type B [Lipid metabolism].	3.39708e-130
NC_016023.1\|WP_014097009.1\|1866741_1867200_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	1.44656e-21
NC_016023.1\|WP_014096995.1\|1851575_1852490_-\|AEC-family-transporter	gnl\|CDD\|223751	COG0679, COG0679, Predicted permeases [General function prediction only].	9.79326e-27
NC_016023.1\|WP_014096992.1\|1846463_1847540_+\|hypothetical-protein	gnl\|CDD\|370703	pfam09798, LCD1, DNA damage checkpoint protein. This is a family of proteins which regulate checkpoint kinases. In Schizosaccharomyces pombe this protein is called Rad26 and in Saccharomyces cerevisiae it is called LCD1.	0.00152782
NC_016023.1\|WP_014097002.1\|1857180_1858650_+\|amidase-family-protein	gnl\|CDD\|236029	PRK07487, PRK07487, amidase; Provisional.	0

>NC_016023.1|WP_014096999.1|1855482_1855728_+|aldehyde-dehydrogenase-family-protein
MIEKANRTRYGLAAYCYTNDLGRGLRMMNELEYGIVGINDVAPVTVQGPFGGYKESGIGREGGKSGILEYLEEKYVSIRMM
>NC_016023.1|WP_014096998.1|1854392_1855055_+|tellurium-resistance-protein-TerC
MILKIFLLNLISDLDNLLIITTVVRKYGYEPKQLFFNIVVCLTVSRTIYVAMIQYLTGIPGFRVLAGMILLYIAFRFVSSIQPDSEARPVPSIPAAKMLLIVLAADMLVCMDSVLITSGISTNLLSTMAGMALSLTTVLAFFEFFSEILDKISWVQIVAGGLITHVAITGIFKDPMMKYPVSLLEKVWGFQLHEWINFIALDTAIFLILIGFMIKARNRA
>NC_016023.1|WP_017552300.1|1854040_1854175_+|hypothetical-protein
MIKNEAGKWTVFTYNERTSKAGEKMYNNESDALEEFIKRLREDK
>NC_016023.1|WP_014096997.1|1853448_1853841_+|hypothetical-protein
MIKSGLYTKYNGIEYKVTSDMDGRVMIYTEDKSKVDSTFYDLTGHGIYKKKVNPKELVNCESITTYGVIEGEKVQILQEKDDQFQVGTGSLFIGEKLQLKRVERDSWIGWISKSRVKIIEERRPVNPEKL
>NC_016023.1|WP_014096996.1|1852877_1853138_-|hypothetical-protein
MDKGIDQNVILQAIRELSDQIKSMEKNLSERMSALESRMEALETRTAALEEGQKEIKELVRKIDKKLDVLNRDLLDTRADVEFLKK
>NC_016023.1|WP_014096995.1|1851575_1852490_-|AEC-family-transporter
MGVVLTKAASFILIIVLGYILKRVGFFKPNDFQLVSRMVLNITLPCAVITNFEKLSLETSLLMLVAIGVICNLVMIATGYIVSWRRTHTEKAFNMINYSGYNIGCFTLPYVQNFLGPVGVVATCLFDAGNSVLCTGGTYSIASAVANNERTNAASYLKKMFSSIPMDTYLIMLVLSLLHITLPAGVTAFTGIVGQANGFLAMLMIGIGFELRLEKSQVASILKAVIIRYGMAILFAVFFYFLLPLPLEVRLVLVIIAFAPISAVCTAFTQKCGGNVAMSSTLNSLSILISIVLMTSLMAVLKIA
>NC_016023.1|WP_014096994.1|1849550_1851335_+|DUF2357-domain-containing-protein
MDTQSNTGFSVVFTHIYQDGTREEKVLTPFVENLYEWDEGKHGYLILREYIPLELSFTSTDDGAKCYMDGFDILLNAGLPVDGEGKPYLAAGQQVTLFKYHSNEEYYPYIPGIYCVTIHTRGKKYYSLVKVISNRLTEDQLSTMRKEVEDQLRGLALDVVRKQHVNMKFENMPIDPNLFRQFNTLNSYFSDVSAIVSDLAKRVRYTLKKEYRLQPIERPSQIDEVSIRYRLKHPESADELLSLKKRINYDLPENRMLKMIIEKWVKLLDHFIAALDTCIGQLENNTNSAFSSYTPYEKRKLFLKELGQYRDRAAQMKGALNVLKTCHWYHEIANQHPLSTPNKMLEDIRYRKIWQVSRILDSEEVNVSLHPAWRYQWKRTDQLYEIWGYLQVLSHFCGSTYDFEKRSGWIFEPDGWNSGNLFVIPTIPKGTTVSLLRGDLRLQIVYDGKIPSDMEKTDPADFPVYTTSTNNNPDIRVDVFIGGIFIGAILMDLKYRKKTALSDTMKQLISYADNVRSPYIYRKKRWQRIRPVHQVLVFYPEKGGAGEAEPLSEKSISLIPLTPATDQKVFVETIRSLIEDMILAAEDEGIVLLD
>NC_016023.1|WP_014096993.1|1847539_1849567_+|AAA-family-ATPase
MGVKVWGNDMIGVLAESDPFDLSNRDTIIINKQDCLQFFIKIISQPAASFPNVKTVTGFYSDLERWGFEDDYRLTDFERKDRLREWLEDRLFVFKVEKRLRYNHEEVFNAIDVRIIPKLPSFHTNLRLIPVPVFNKEAHHIEKDEFLFRLYNKKFVGKVENLSHEPDDTPSLVMWREEDEEDDHFSVFGQIDHHQHAHGGFNFEIQGELKEVGLTPEWIEECYFSDEIPNIVFVPLELYTKLTTLVEQAVPLNLEKLEKEEANPAIEQTNKVQEDPKKIPNVQMQAEAAATLQVEGIQTPDPDLTPYNAKENKFLDNLFTTTRDFGFVYEKKDLINFHTCMKSSSLVILSGMSGTGKTKLVELYSHALGLKGIQYTLIPVSPSWTSDSDLIGYADTLHMVYRPGDSGLINALRKAEDEKDKLFIICFDEMNLARVEHYFSQFLSILEMDHGKRELRLYNDDLESRLYNSAQYPPTIAIRENVLFVGTVNVDESTYHFSDKVLDRANVLSLEIMPFEHMKKLPERKKIFALGTEEVDFETYTSFKADRRNVALMDEELKFLWKVHQALHDANKQIGVGPRIVKQIDAYLANLPVQDVLTREQAFDLQMVQRILTKLRGSEDQLRELAGVYDKETGEVNGSILLNLFDQHQQVSDFEKSREIVKQKAKELKLNGYTI
>NC_016023.1|WP_014096992.1|1846463_1847540_+|hypothetical-protein
MEKEIWKKIFSTIPDDELANLIRIWKISIRGFRHITSKDITRIRALVTRECLKESNLKKIQDFYKIVAAKDEDDVRDKTVHELFKLYQDGKTLHLILGALYSSPEDRHHERAKQFEELVCKKNGLSSLDELRVLTEKTEPPKQEDEHDSAHWQKKWQKSQKKNQELQKSIKKCELLLSHLKKDWKAEKQSWKKEKEQLQQELGNERTQKNRLNEWKKTSEAEMQRLKDEIQKLKLEISHLNALLLNTNKEVAAAVQTDEWVESKPSESTAAARQIYIIGDPKNKLIDESENPLFHTIEANKFKEAVQTGELEDADEIWMMAYLVPPWLKKKIKNVYTQKVREFKDFPSVKKYIERGIK
>NC_016023.1|WP_088775945.1|1844713_1846258_+|GNAT-family-N-acetyltransferase
MVPETDVSKFEKKIEVRNIRFEDIDDIMALSKKCFPGMEPWKREQLESHIRIFPEGQFCVEYEGKVVGSCSSLIVNFDEYEDQHTWDTITANGYITNHNPHGLNLYGIEVMIDPEYRRMKFGHRLYEARKELCRKMNLQSIIIGGRIPNYSKYKDKMTPREYVEEVEMHNIYDPVLSFQLLEGFQIMRINRQYLPDDTASASFATLMEWHNVDYLPKSRRVYHASFPVRITAIQYMMKKIDSFDDFVRQVEYYVDVAADFGSDFAVFPEIFTTQLMSYLEEKRPDQAVRRLSEYTDQYIELFTELAVRYNVNIIGGSHFVEEDGGIYNVAFLFRRDGTIERQTKLHITPNERKWWGIAEGNELNVFDTDCGKIAILICYDIEFPELARVAVDYGANIIFVPFCTDDRQAYLRVRYCAQARAIENQVYTCIAGTVGNLTHVENMDIQYAQSGIFSPSDFGFARDGIVGECDPNVDTVVVGDVDLEKLRRNRNSGSVRQLADRRRDLYQIKINSKS
>NC_016023.1|WP_014097002.1|1857180_1858650_+|amidase-family-protein
MINPKALSSGFELSQKNTDELWRWSAAELAYAIRTKQISSREAVMSCLKRIEEVNPKVNALVEVLAEGALRAADASDRSVLKGEDLGPLHGVPVATKINTDQAGHVTTDGVVAFQHNVATDDSPPVAHLRKAGAVFVGRSNVPSFSLRWVSNNDLHGSTLNPWDPTRTPGGSSGGAASAVACGMAPIAQGNDIGGSIRYPAYACGITGIRPTIGRVATGADLPNGDPPLSLQMKVTEGPLARNVADLRLALSVMSAYDPRDPVHANVPLIGEPLKKPIRVGLLRDPGVVKPDPAVNQALNEAAAYLNDAGYVVEEVDLPLFAEAYKLWYLLVLEDLTDLWPAIKQFGDEGARLNLQYNYEVSRQWWGEVTLEKYRTGYARRGTLIIALQKFMEQYPILLLPVSAEQAFKQNEDIKSIDSNARLMAAQWPMMSIALLGFPAISVPTSVSGGLPTGVQIVGRRFREDTILDAAEIIESRANIQVPIDPLFH
>NC_016023.1|WP_014097003.1|1858702_1860175_+|carboxylesterase/lipase-family-protein
MIAKTISSSNMTYIGQEESGVISFKGIPYAKPPVGKRRWKAPEDLDPEPKRIEAFSYGSPCIQPVDENEPSSFGNQSEDCLTLNIWTRELEGAKKPVMVFIHGGGFIGGGSNDPLYDGKSFVKRNDIVLVSINYRVNIFGFLDLEELGGKAYADSKNLGILDQIKALEWINAHIHLFGGDPGNITIFGESCGGASVSLLMTIPKAKGLFHKVIAQSGTVNLVKNEETAKQIGRDFVKLTGARSVEDLLALDADQLRAYCDRLIDLYQYKSEIMFAPAADGKWIPLNPYQEIENGCAAGIDCMIGTTKDEMAYWRLYYPDLDDILEDYLNQQLSIIESMSGIVAAAAQHRKQASSADLYQIANDILFHIPAIKFAESQSRFASTWMYFFTWSSRIKGLGACHAIDLPFVFHNLKSGEWLTGKEPPVTLADRMQDAWVSFARNGNPAHPAIPAWPAYDPDHRSVMQIDENWRCIRGHVPEILRTKKSTQKVE
>NC_016023.1|WP_014097004.1|1860556_1861156_+|DUF3237-family-protein
MTIGLEFAFQAYVSIDEDLTIGPVPGGIRNITPITGGVFEGPGIKGTVIPGGADWSLTRENGVIDICARYTLKTDDDVLIYVINKGLYIEKPGGLQERPASREGVEPMPEYFRTTPVFEVLNEKYDWLNRNIFVCDPLCDHAGKRIGTNLGILMPEIKNRCNGHVHFFYHGARRSCHFTNHVKNENNGRKQARCGRRGS
>NC_016023.1|WP_041818023.1|1861115_1861964_+|helix-turn-helix-domain-containing-protein
MEENKRVAEEEVARKLLAGKDCEQAEMKAVLPGYSASLHFRVILFKVTKPQSGTKDWEETLLQLSAMMKNRIKKKGMLSLISAAKDEIAAICFFKKDEQANHDLVTFSDIHQSLVQLSIKDRYNGKHTMTGISKAYKNTADVCRAYDDAKKVIFLQQINLLQEIFYDKIGIYQILLLGEKNEYVETFIYDQLGPVLEYDAKMNASLLTTLEVYLKNRGRKKEMANELFIVRQTLYHRLEKIEELLGYQFMEPARRLALETAILAYHIYQSGHTHFNLEDYQL
>NC_016023.1|WP_014097006.1|1862335_1863757_+|C40-family-peptidase
MTRKKVLSVTAGMTLASLIVGSASTEAATYTVKKGDSLWKISQQYHTTVSQIKNDNHLTGDIIYPNQKFKVPSQTPKKYKIVSGDTLSGIAKKYGVKVSQLKEWNNLSSDLIYAGDTLKINSSSATVSSTANSTGNSTSNSTSNSIANSNSNSAANNSTANSSTANNTAKSAATQKSTAPNGTYQIVKGDTLSGVAQKFGVTVSQLKEWNHLSSDWIVAGSALKVDGPSSAVSSSNGSSTQSNQSSGAASSSSNAGSASSQTSGSSSTQSSSSNNSGSTTNSTQSSQSSNAQSSSQASGSTSSSQSSQSSSAQSNSSNAGSSSSSSASTSSSQASSSRAVSKNTVSSSSNSGSYSGSAVAQIAQKYIGAPYRFGGTTPSGFDCSGFVFYVYNQAGKSIGRQTAAGYYGSSYQVSSPQPGDLIFFQDTYKSGISDVGIYLGNNQFISDSDKSVSIKSLSNPYWKSHFNSIRRFY
>NC_016023.1|WP_014097008.1|1865775_1866354_+|HAD-IA-family-hydrolase
MNILWDFDGTLFDTYPVYTNIFSQVLGETVDKREIYGKLKISYSHAIHFYDISSEQEEEIKKLKKNISPEDMKPFNGVEGILNFANKNVIVTHKSREGVVGILKYYGWDKYFVDMVTIDDGFPRKPNPSAYKHLHEKYRIDLAIGDRELDLLPAKELGISTCIFQNQTDIADYQLQDYTEFFNTNIPEKLNM
>NC_016023.1|WP_014097009.1|1866741_1867200_+|MarR-family-transcriptional-regulator
MEDSKMDQFLTHWRYINRHLREGRLANEDKKITRLQWILLRHVGRSGQCTMGSLAEHFNVSMSTVSQMIDRLEKWGYARRVTSARDGRVKMVSLTEKGEAIINEAKTAYLQQLSNGLSKFSEEEQELFIGFLQRLAENLKVSKGDPQTDKKA
>NC_016023.1|WP_014097010.1|1867241_1868996_+|ABC-transporter-ATP-binding-protein
MHFLNKYTKKYWKLFSTAVFFLMCEALCDLMQPAILSKIIDVGVTSRNMPYVLKMGGVMLFITACGAVAASLRSTLASIVSQNFGAELRSDLFRKIQALSFQNINRFDRASLITRLTNDVTQVQSFINGLMRMFVKAPLLAIGALIMAVRLDPQLSVVLAVVVPIVIIFIIANMRLGFPLFMKVQKALDRVNGIMREYLSGVRVVKAFNQFQFEVEKFSVANRRLRERSTSSIRIMSIFSPAILLTVNFGIVAILWMGGFGVNNGTMKVGHIIAFINYMTQISTSLMMISMVFNMFVRARASTFRIGEVFAVEEKTFPNRLKHEVMAERGRIDFENVTFSYTGRGEDAVLKNITFTIYPGETVGIIGSTGSGKSTLVNLIPRFYDVTGGSLKVDGMDVRDFHPHDLREKIALVPQKNILFTGSVRENIQWGNDRAGMDEIERAARLAEAHDFIAAAPEGYDTMIGQSGVNFSGGQKQRISIARALVRHPEILILDDSTSAVDVATEMRIKAALKRYAKGMTCLLIAQRITSVMDTDKIIVLEKGEVAGLGTHEELLRASHVYQEIYQSQMGKEVLQDGRTNEQI
>NC_016023.1|WP_014097011.1|1868970_1870833_+|ABC-transporter-ATP-binding-protein
MAGQTNRYKGNQAPGPFLRMVRPGGGGAARFRGPVEKPKQFKGTLKRLWAYFGRERNGLSVILALIVADSVLTLCIPYFIGRAVDAMPPGRKVHFNLLEIMIFVLTAAYIADAVLTFLQGWLVAGVSQRIVQRLRSHLFQKLQKLPVSFFDARTHGELMSRLSNDIDNVSNTISQSTTQLMSGVIALLGTLMMMIILSPVLTVASLCTVPLVFLLTRTIAKRTSVLFKNNQAELGRLNGHIEETISGIEVVKAFNHEEKAIKKFEEVNQSLLKVGLRAQIWSGFLMPLMNVINNFGFAMVAVVGGVLALKGMITVGVIASFLTYSRQFVRPLNNLANIFNVLQSGVAGAERVFDILDEKEEAEDAREAIVLQDPKGHVVFENVSFGYREDVPIIKNISFEAKPGTRTALVGPTGAGKTTIVNLLTRFYDVTEGRISIDGTDIRKYTRDSLRRSFGFVLQDTYLFAGTIKENIKYGNPKATDEEVEEAARLAHADIFINRMPDKYETILSENGGNLSQGQRQLLAIARVFLAKPALLILDEATSSIDTRTERFIQDALLSMMEGRTSFIIAHRLNTIRDADHIMVIDHGQIIEQGSHDELMAHRGRYYHMFYNQFKNVGEG
>NC_016023.1|WP_014097012.1|1870885_1871299_-|hypothetical-protein
MKNEDFPIRRILFHPEIISIDLVKIAQEMTEDQFDEFLTQYDKAIQIAMKNPYLPNTRLMYQLQDWSRIDFFSMKKPPRKFTRDDRFIYRYDADFYDVFKLAVGLRNAKGKQGDSIYYTARIRLEESPDHWEEENDG

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Crispr_ID: NC_016023_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016023_11

2117433-2121795

TypeI-B

Consensus_repeat	Method
GTTTCAATTCCTCATAGGTAAAATACAAAC	PILER-CR
GTTTGTATTTTACCTATGAGGAATTGAAAC	CRISPRCasFinder
GTTTGTATTTTACCTATGAGGAATTGAAAC	CRT
GTTTCAATTCCTCATAGGTAAAATACAAAC	PILER-CR

65 spacers

cas2,cas1,cas4,cas3,cas5,cas7b,cas8b1,cas6

The CRISPR arrays of NC_016023_11

>merge|NC_016023|11|2117433-2121795|PILER-CR,CRISPRCasFinder,CRT,PILER-CR
GTTTGTATTTTACCTATGAGGAATTGAAACTAGGTTACCCGCTGTCACAAACCGGATCCGGAGACAAGCGTTTGTATTTTACCTATGAGGAATTGAAACATCGCGTCCGTGAGTTTGCCCCAGTATGCCGGGTTCGTTTGTATTTTACCTATGAGGAATTGAAACAAGTGATGATCGCGACACATCCAGATGCCGATCATAGTTTGTATTTTACCTATGAGGAATTGAAACAATGAGAAGATGGGAAGTACTTGCAATGCTAAACGGGTTTGTATTTTACCTATGAGGAATTGAAACCGGTGTCGCCTTCCACGTCCAGCGCTAAAAATTTTGCGTTTGTATTTTACCTATGAGGAATTGAAACTACCTCCCGGATTCAAATCCCTTTTTCTCGATCGCTGGTTTGTATTTTACCTATGAGGAATTGAAACCGAGTGTAAACAGTGTAGACAGTACTTCCGTCTGCTGTTTGTATTTTACCTATGAGGAATTGAAACTCTGACGGTCCGAGGGCTGCCCAACGGCACAAAGTGTTTGTATTTTACCTATGAGGAATTGAAACGGGCAAAAATTTCACGAAACCGCTTTTGCATATTTCCCCGTTTGTATTTTACCTATGAGGAATTGAAACGATTGTCTTCCAGAACCGCGTTTTCCCTCAATGTAGCCCGTTTGTATTTTACCTATGAGGAATTGAAACCCTGATACTGGCGCTGTATACCAAATAGTTTCGCCTGTTTGTATTTTACCTATGAGGAATTGAAACTCATTGAATATGATAAAATAAATGAATTGGATGTCGTTTGTATTTTACCTATGAGGAATTGAAACAAGTTGTTGGTATGCGTGACGGCGATGATGTAACGGGGTTTGTATTTTACCTATGAGGAATTGAAACACACTAAACCGGTTAGCACGTCTACCACCAGTACAGTGTTTGTATTTTACCTATGAGGAATTGAAACCACCATGCTTTCATGACCAAAAGTTTTGCGGATGAACCGTTTGTATTTTACCTATGAGGAATTGAAACACAGCATGACAGCTATCAATTCGCAAGCGATCAAAGAGCGTTTGTATTTTACCTATGAGGAATTGAAACAGCGACAACGAACACAATAAGTCTGTATCATATCCGTTTGTATTTTACCTATGAGGAATTGAAACATTTTTAAACAGATCTGCTATCCCCGTGACCTGCTTGTTTGTATTTTACCTATGAGGAATTGAAACTTCTGCTTCAGTATCTACATATGTACCAATGTATAAGTTTGTATTTTACCTATGAGGAATTGAAACGCGTCTTGCTTTCGTTTCCATTCCACCATATTCGCGGTTTGTATTTTACCTATGAGGAATTGAAACTTTTGGGGTGTGAGGCTGGCTGGGGGTGTGGGGGCGTTTGTATTTTACCTATGAGGAATTGAAACGCGGTATGATGGATGGAGCAAGCCGACCCTCGGAGCTGTTTGTATTTTACCTATGAGGAATTGAAACTTTGACGGACTCGTCGCAATGGATCCGCCTTTTTTCGTGTTTGTATTTTACCTATGAGGAATTGAAACACCAGGAACAGCTTGCTTTTGATTTGAATGTGTCCCCGTTTGTATTTTACCTATGAGGAATTGAAACCAAGTATTTAAAAATCCACAACTGAATACAGAACGGGTTGTATTTTACCTATGAGGAATTGAAACATTCTTCGATGTCCTCCCTTAGCTGGTCCATCCCAGTTTGTATTTTACCTATGAGGAATTGAAACCGGATATTGTAAAGGATGAACACACATATCATAACGTTTGTATTTTACCTATGAGGAATTGAAACTGAGGAGGGGGCTGATATGGTGAACGTTTCCTTTGAGTTTGTATTTTACCTATGAGGAATTGAAACAAATACGGATAGGGTAACAAAAAAGGCGACCGCAATGTTTGTATTTTACCTATGAGGAATTGAAACCGTAATCCCCGACTTTCAGCTTCGGCGCCGTGTATTGTTTGTATTTTACCTATGAGGAATTGAAACATAGATTATGGTGTACCGGATGTACCGTTGGTAAAGGTGTTTGTATTTTACCTATGAGGAATTGAAACCGGAAAGCCGTTAAAATTCTGCAAACTGTGCCGCCACGTTTGTATTTTACCTATGAGGAATTGAAACCTGTTCTTTTGGACTCTGTATATATTGGCCATGCTTTGTTTGTATTTTACCTATGAGGAATTGAAACGCCGGTATTTCGTTTGATCGCACCGGATATGCAACGTTTGTATTTTACCTATGAGGAATTGAAACTCTGGCCCGAAAGCAATCTTCATTTTGACCACTTCTGTTTGTATTTTACCTATGAGGAATTGAAACTACAAAATGGAGGTAAATGAATATGGCAAGTATACAGTTTGTATTTTACCTATGAGGAATTGAAACATCCGAGCCGTGATAAAATTGATACTCCCTTGCCAGTGGTTTGTATTTTACCTATGAGGAATTGAAACTAACAATTGAGCCGTTTGGTATTGATCTCGAACTAGTTTGTATTTTACCTATGAGGAATTGAAACAACGTAAATATCGCGCAGCTGGCGCTCAACAAGGCGCGTTTGTATTTTACCTATGAGGAATTGAAACTCGGTAGTGGTAAAAGTTATCACGCTGTCAGAGACGGTTTGTATTTTACCTATGAGGAATTGAAACTCGTATTTCACCTCGACATTAAACCGCGCTGGCTTTGGTTTGTATTTTACCTATGAGGAATTGAAAAAAAATAAGCATCGCAGTACATGGCGAGATGGCCGAGTTTGTATTTTACCTATGAGGAATTGAAACTATAGCTGATGTCCGCATATAATTCATAGCTGTCGTCCGTTTGTATTTTACCTATTTTGTATTTTACCTATGAGGAATTGAAACAGCAGTGTAAACAAAAAAAAAGAAGGAGCTGAAAAGGTTTGTATTTTACCTATGAGGAATTGAAACTTATTTCTGTAAACCGGCTTTCCATTTCTTCGTACACTGTTTGTATTTTACCTATGAGGAATTGAAACTCGAAAAAGCAAGCGCAGGGCGTGCATGATGTCATGTTTGTATTTTACCTATGAGGAATTGAAACAGCGTAAATCAAAATATTATTTAATGATCGTGTACGTTTGTATTTTACCTATGAGGAATTGAAACACAAGGGGCGCGACGGCGGCGAAGGGGAGCAGTCAGAAGTTTGTATTTTACCTATGAGGAATTGAAACATGCGTATGGCGTACGAAGCAGGAAAAGCTGGCGAGTTTGTATTTTACCTATGAGGAATTGAAACCTTACATTCTGCTTTCTAGTAACCCACATGAGATTGCGTTTGTATTTTACCTATGAGGAATTGAAACCTGTCTGTGCTGCTTGTGCTGCATCTGCAGCTGTAGCGTTTGTATTTTACCTATGAGGAATTGAAACCGGGCATTGTGCCAAGCGTTAATGCCGACCAGTCCAGTTTGTATTTTACCTATGAGGAATTGAAACTGCAACGCCCCATGCTTTTGTAGCTCCCGCGGCTATGTTTGTATTTTACCTATGAGGAATTGAAACCGGTAATGTGTACGCCCTCTACGTGTGGCATGCGCGTTTGTATTTTACCTATGAGGAATTGAAACCACGTAAATACATTCATGCTATAATGAAATCAAGATAAGTTTGTATTTTACCTATGAGGAATTGAAACCATCTATGCTATCTATGGTATAATAGAAGCATAAGGAGTTTGTATTTTACCTATGAGGAATTGAAACGTTAGCTATGGCTTCTCTTTCCGCTTCCTCCTCCGTGTTTGTATTTTACCTATGAGGAATTGAAACGGCTTTGACAGGGACATAATTCCTTAGATCGCTTGTAGTTTGTATTTTACCTATGAGGAATTGAAACCGGGCATTGTGCCAAGCGTTAATGCCGACCAGTCCGTTTGTATTTTACCTATGAGGAATTGAAACGAATACGACTTCGCATGTACTGCGTTTTCCATCGCGTTTGTATTTTACCTATGAGGAATTGAAACCGCTTAAATATACGTACTCCGCCAAGTGACGCAGGGTTTGTATTTTACCTATGAGGAATTGAAACCAATACATGGGCATGCCTAAAGGGAAGTTCCCAGTCGTTTGTATTTTACCTATGAGGAATTGAAACCGGGACTGGTCCATTGGAGCATATAACCACAATTATGTTTGTATTTTACCTATGAGGAATTGAAACAAAGGGGTATGGGCCTACAAGAAATCCGGGTGTCAAGGTTTGTATTTTACCTATGAGGAATTGAAACGTACGCCCGGTACGCATCCAAACCTATTGGGGTTTCCGTTTGTATTTTACCTATGAGGAATTGAAAC

>NC_016023|11|2|2117433-2120189|PILER-CR
GTTTGTATTTTACCTATGAGGAATTGAAAC	TAGGTTACCCGCTGTCACAAACCGGATCCGGAGACAAGC
GTTTGTATTTTACCTATGAGGAATTGAAAC	ATCGCGTCCGTGAGTTTGCCCCAGTATGCCGGGTTC
GTTTGTATTTTACCTATGAGGAATTGAAAC	AAGTGATGATCGCGACACATCCAGATGCCGATCATA
GTTTGTATTTTACCTATGAGGAATTGAAAC	AATGAGAAGATGGGAAGTACTTGCAATGCTAAACGG
GTTTGTATTTTACCTATGAGGAATTGAAAC	CGGTGTCGCCTTCCACGTCCAGCGCTAAAAATTTTGC
GTTTGTATTTTACCTATGAGGAATTGAAAC	TACCTCCCGGATTCAAATCCCTTTTTCTCGATCGCTG
GTTTGTATTTTACCTATGAGGAATTGAAAC	CGAGTGTAAACAGTGTAGACAGTACTTCCGTCTGCT
GTTTGTATTTTACCTATGAGGAATTGAAAC	TCTGACGGTCCGAGGGCTGCCCAACGGCACAAAGT
GTTTGTATTTTACCTATGAGGAATTGAAAC	GGGCAAAAATTTCACGAAACCGCTTTTGCATATTTCCCC
GTTTGTATTTTACCTATGAGGAATTGAAAC	GATTGTCTTCCAGAACCGCGTTTTCCCTCAATGTAGCCC
GTTTGTATTTTACCTATGAGGAATTGAAAC	CCTGATACTGGCGCTGTATACCAAATAGTTTCGCCT
GTTTGTATTTTACCTATGAGGAATTGAAAC	TCATTGAATATGATAAAATAAATGAATTGGATGTC
GTTTGTATTTTACCTATGAGGAATTGAAAC	AAGTTGTTGGTATGCGTGACGGCGATGATGTAACGGG
GTTTGTATTTTACCTATGAGGAATTGAAAC	ACACTAAACCGGTTAGCACGTCTACCACCAGTACAGT
GTTTGTATTTTACCTATGAGGAATTGAAAC	CACCATGCTTTCATGACCAAAAGTTTTGCGGATGAACC
GTTTGTATTTTACCTATGAGGAATTGAAAC	ACAGCATGACAGCTATCAATTCGCAAGCGATCAAAGAGC
GTTTGTATTTTACCTATGAGGAATTGAAAC	AGCGACAACGAACACAATAAGTCTGTATCATATCC
GTTTGTATTTTACCTATGAGGAATTGAAAC	ATTTTTAAACAGATCTGCTATCCCCGTGACCTGCTT
GTTTGTATTTTACCTATGAGGAATTGAAAC	TTCTGCTTCAGTATCTACATATGTACCAATGTATAA
GTTTGTATTTTACCTATGAGGAATTGAAAC	GCGTCTTGCTTTCGTTTCCATTCCACCATATTCGCG
GTTTGTATTTTACCTATGAGGAATTGAAAC	TTTTGGGGTGTGAGGCTGGCTGGGGGTGTGGGGGC
GTTTGTATTTTACCTATGAGGAATTGAAAC	GCGGTATGATGGATGGAGCAAGCCGACCCTCGGAGCT
GTTTGTATTTTACCTATGAGGAATTGAAAC	TTTGACGGACTCGTCGCAATGGATCCGCCTTTTTTCGT
GTTTGTATTTTACCTATGAGGAATTGAAAC	ACCAGGAACAGCTTGCTTTTGATTTGAATGTGTCCCC
GTTTGTATTTTACCTATGAGGAATTGAAAC	CAAGTATTTAAAAATCCACAACTGAATACAGAACG
GGTTGTATTTTACCTATGAGGAATTGAAAC	ATTCTTCGATGTCCTCCCTTAGCTGGTCCATCCCA
GTTTGTATTTTACCTATGAGGAATTGAAAC	CGGATATTGTAAAGGATGAACACACATATCATAAC
GTTTGTATTTTACCTATGAGGAATTGAAAC	TGAGGAGGGGGCTGATATGGTGAACGTTTCCTTTGA
GTTTGTATTTTACCTATGAGGAATTGAAAC	AAATACGGATAGGGTAACAAAAAAGGCGACCGCAAT
GTTTGTATTTTACCTATGAGGAATTGAAAC	CGTAATCCCCGACTTTCAGCTTCGGCGCCGTGTATT
GTTTGTATTTTACCTATGAGGAATTGAAAC	ATAGATTATGGTGTACCGGATGTACCGTTGGTAAAGGT
GTTTGTATTTTACCTATGAGGAATTGAAAC	CGGAAAGCCGTTAAAATTCTGCAAACTGTGCCGCCAC
GTTTGTATTTTACCTATGAGGAATTGAAAC	CTGTTCTTTTGGACTCTGTATATATTGGCCATGCTTT
GTTTGTATTTTACCTATGAGGAATTGAAAC	GCCGGTATTTCGTTTGATCGCACCGGATATGCAAC
GTTTGTATTTTACCTATGAGGAATTGAAAC	TCTGGCCCGAAAGCAATCTTCATTTTGACCACTTCT
GTTTGTATTTTACCTATGAGGAATTGAAAC	TACAAAATGGAGGTAAATGAATATGGCAAGTATACA
GTTTGTATTTTACCTATGAGGAATTGAAAC	ATCCGAGCCGTGATAAAATTGATACTCCCTTGCCAGTG
GTTTGTATTTTACCTATGAGGAATTGAAAC	TAACAATTGAGCCGTTTGGTATTGATCTCGAACTA
GTTTGTATTTTACCTATGAGGAATTGAAAC	AACGTAAATATCGCGCAGCTGGCGCTCAACAAGGCGC
GTTTGTATTTTACCTATGAGGAATTGAAAC	TCGGTAGTGGTAAAAGTTATCACGCTGTCAGAGACG
GTTTGTATTTTACCTATGAGGAATTGAAAC	TCGTATTTCACCTCGACATTAAACCGCGCTGGCTTTG
GTTTGTATTTTACCTATGAGGAATTGAAAAAAAATAAGCATCGCAGTACATGGCGAGATGGCCGAGTTTGTATTTTACCTATGAGGAATTGAAACTATAGCTGATGTCCGCATATAATTCATAGCTGTCGTCCGTTTGTATTTTACCTATTTTGTATTTTACCTATGAGGAATTGAAACA	GCAGTGTAAACAAAAAAAAAGAAGGAGCTGAAAAGG
TTTGTATTTTACCTATGAGGAATTGAAACT	TATTTCTGTAAACCGGCTTTCCATTTCTTCGTACACTG
TTTGTATTTTACCTATGAGGAATTGAAACT	CGAAAAAGCAAGCGCAGGGCGTGCATGATGTCATG
TTTGTATTTTACCTATGAGGAATTGAAACA	GCGTAAATCAAAATATTATTTAATGATCGTGTACG
TTTGTATTTTACCTATGAGGAATTGAAACA	CAAGGGGCGCGACGGCGGCGAAGGGGAGCAGTCAGAAG
TTTGTATTTTACCTATGAGGAATTGAAACA	TGCGTATGGCGTACGAAGCAGGAAAAGCTGGCGAG
TTTGTATTTTACCTATGAGGAATTGAAACC	TTACATTCTGCTTTCTAGTAACCCACATGAGATTGCG
TTTGTATTTTACCTATGAGGAATTGAAACC	TGTCTGTGCTGCTTGTGCTGCATCTGCAGCTGTAGCG
TTTGTATTTTACCTATGAGGAATTGAAACC	GGGCATTGTGCCAAGCGTTAATGCCGACCAGTCCAG
TTTGTATTTTACCTATGAGGAATTGAAACT	GCAACGCCCCATGCTTTTGTAGCTCCCGCGGCTATG
TTTGTATTTTACCTATGAGGAATTGAAACC	GGTAATGTGTACGCCCTCTACGTGTGGCATGCGCG
TTTGTATTTTACCTATGAGGAATTGAAACC	ACGTAAATACATTCATGCTATAATGAAATCAAGATAAG
TTTGTATTTTACCTATGAGGAATTGAAACC	ATCTATGCTATCTATGGTATAATAGAAGCATAAGGAG
TTTGTATTTTACCTATGAGGAATTGAAACG	TTAGCTATGGCTTCTCTTTCCGCTTCCTCCTCCGTG
TTTGTATTTTACCTATGAGGAATTGAAACG	GCTTTGACAGGGACATAATTCCTTAGATCGCTTGTAG
TTTGTATTTTACCTATGAGGAATTGAAACC	GGGCATTGTGCCAAGCGTTAATGCCGACCAGTCCG
TTTGTATTTTACCTATGAGGAATTGAAACG	AATACGACTTCGCATGTACTGCGTTTTCCATCGCG
TTTGTATTTTACCTATGAGGAATTGAAACC	GCTTAAATATACGTACTCCGCCAAGTGACGCAGGG
TTTGTATTTTACCTATGAGGAATTGAAACC	AATACATGGGCATGCCTAAAGGGAAGTTCCCAGTCG
TTTGTATTTTACCTATGAGGAATTGAAACC	GGGACTGGTCCATTGGAGCATATAACCACAATTATG
TTTGTATTTTACCTATGAGGAATTGAAACA	AAGGGGTATGGGCCTACAAGAAATCCGGGTGTCAAGG
TTTGTATTTTACCTATGAGGAATTGAAACG	TACGCCCGGTACGCATCCAAACCTATTGGGGTTTCCG


>NC_016023|11|10|2117433-2121795|CRISPRCasFinder
GTTTGTATTTTACCTATGAGGAATTGAAAC	TAGGTTACCCGCTGTCACAAACCGGATCCGGAGACAAGC
GTTTGTATTTTACCTATGAGGAATTGAAAC	ATCGCGTCCGTGAGTTTGCCCCAGTATGCCGGGTTC
GTTTGTATTTTACCTATGAGGAATTGAAAC	AAGTGATGATCGCGACACATCCAGATGCCGATCATA
GTTTGTATTTTACCTATGAGGAATTGAAAC	AATGAGAAGATGGGAAGTACTTGCAATGCTAAACGG
GTTTGTATTTTACCTATGAGGAATTGAAAC	CGGTGTCGCCTTCCACGTCCAGCGCTAAAAATTTTGC
GTTTGTATTTTACCTATGAGGAATTGAAAC	TACCTCCCGGATTCAAATCCCTTTTTCTCGATCGCTG
GTTTGTATTTTACCTATGAGGAATTGAAAC	CGAGTGTAAACAGTGTAGACAGTACTTCCGTCTGCT
GTTTGTATTTTACCTATGAGGAATTGAAAC	TCTGACGGTCCGAGGGCTGCCCAACGGCACAAAGT
GTTTGTATTTTACCTATGAGGAATTGAAAC	GGGCAAAAATTTCACGAAACCGCTTTTGCATATTTCCCC
GTTTGTATTTTACCTATGAGGAATTGAAAC	GATTGTCTTCCAGAACCGCGTTTTCCCTCAATGTAGCCC
GTTTGTATTTTACCTATGAGGAATTGAAAC	CCTGATACTGGCGCTGTATACCAAATAGTTTCGCCT
GTTTGTATTTTACCTATGAGGAATTGAAAC	TCATTGAATATGATAAAATAAATGAATTGGATGTC
GTTTGTATTTTACCTATGAGGAATTGAAAC	AAGTTGTTGGTATGCGTGACGGCGATGATGTAACGGG
GTTTGTATTTTACCTATGAGGAATTGAAAC	ACACTAAACCGGTTAGCACGTCTACCACCAGTACAGT
GTTTGTATTTTACCTATGAGGAATTGAAAC	CACCATGCTTTCATGACCAAAAGTTTTGCGGATGAACC
GTTTGTATTTTACCTATGAGGAATTGAAAC	ACAGCATGACAGCTATCAATTCGCAAGCGATCAAAGAGC
GTTTGTATTTTACCTATGAGGAATTGAAAC	AGCGACAACGAACACAATAAGTCTGTATCATATCC
GTTTGTATTTTACCTATGAGGAATTGAAAC	ATTTTTAAACAGATCTGCTATCCCCGTGACCTGCTT
GTTTGTATTTTACCTATGAGGAATTGAAAC	TTCTGCTTCAGTATCTACATATGTACCAATGTATAA
GTTTGTATTTTACCTATGAGGAATTGAAAC	GCGTCTTGCTTTCGTTTCCATTCCACCATATTCGCG
GTTTGTATTTTACCTATGAGGAATTGAAAC	TTTTGGGGTGTGAGGCTGGCTGGGGGTGTGGGGGC
GTTTGTATTTTACCTATGAGGAATTGAAAC	GCGGTATGATGGATGGAGCAAGCCGACCCTCGGAGCT
GTTTGTATTTTACCTATGAGGAATTGAAAC	TTTGACGGACTCGTCGCAATGGATCCGCCTTTTTTCGT
GTTTGTATTTTACCTATGAGGAATTGAAAC	ACCAGGAACAGCTTGCTTTTGATTTGAATGTGTCCCC
GTTTGTATTTTACCTATGAGGAATTGAAAC	CAAGTATTTAAAAATCCACAACTGAATACAGAACG
GGTTGTATTTTACCTATGAGGAATTGAAAC	ATTCTTCGATGTCCTCCCTTAGCTGGTCCATCCCA
GTTTGTATTTTACCTATGAGGAATTGAAAC	CGGATATTGTAAAGGATGAACACACATATCATAAC
GTTTGTATTTTACCTATGAGGAATTGAAAC	TGAGGAGGGGGCTGATATGGTGAACGTTTCCTTTGA
GTTTGTATTTTACCTATGAGGAATTGAAAC	AAATACGGATAGGGTAACAAAAAAGGCGACCGCAAT
GTTTGTATTTTACCTATGAGGAATTGAAAC	CGTAATCCCCGACTTTCAGCTTCGGCGCCGTGTATT
GTTTGTATTTTACCTATGAGGAATTGAAAC	ATAGATTATGGTGTACCGGATGTACCGTTGGTAAAGGT
GTTTGTATTTTACCTATGAGGAATTGAAAC	CGGAAAGCCGTTAAAATTCTGCAAACTGTGCCGCCAC
GTTTGTATTTTACCTATGAGGAATTGAAAC	CTGTTCTTTTGGACTCTGTATATATTGGCCATGCTTT
GTTTGTATTTTACCTATGAGGAATTGAAAC	GCCGGTATTTCGTTTGATCGCACCGGATATGCAAC
GTTTGTATTTTACCTATGAGGAATTGAAAC	TCTGGCCCGAAAGCAATCTTCATTTTGACCACTTCT
GTTTGTATTTTACCTATGAGGAATTGAAAC	TACAAAATGGAGGTAAATGAATATGGCAAGTATACA
GTTTGTATTTTACCTATGAGGAATTGAAAC	ATCCGAGCCGTGATAAAATTGATACTCCCTTGCCAGTG
GTTTGTATTTTACCTATGAGGAATTGAAAC	TAACAATTGAGCCGTTTGGTATTGATCTCGAACTA
GTTTGTATTTTACCTATGAGGAATTGAAAC	AACGTAAATATCGCGCAGCTGGCGCTCAACAAGGCGC
GTTTGTATTTTACCTATGAGGAATTGAAAC	TCGGTAGTGGTAAAAGTTATCACGCTGTCAGAGACG
GTTTGTATTTTACCTATGAGGAATTGAAAC	TCGTATTTCACCTCGACATTAAACCGCGCTGGCTTTG
GTTTGTATTTTACCTATGAGGAATTGAAAA	AAAATAAGCATCGCAGTACATGGCGAGATGGCCGA
GTTTGTATTTTACCTATGAGGAATTGAAAC	TATAGCTGATGTCCGCATATAATTCATAGCTGTCGTCC
GTTTGTATTTTACCTATTTTGTATTTTACC	TATGAGGAATTGAAACAGCAGTGTAAACAAAAAAAAAGAAGGAGCTGAAAAG
GTTTGTATTTTACCTATGAGGAATTGAAAC	TTATTTCTGTAAACCGGCTTTCCATTTCTTCGTACACT
GTTTGTATTTTACCTATGAGGAATTGAAAC	TCGAAAAAGCAAGCGCAGGGCGTGCATGATGTCAT
GTTTGTATTTTACCTATGAGGAATTGAAAC	AGCGTAAATCAAAATATTATTTAATGATCGTGTAC
GTTTGTATTTTACCTATGAGGAATTGAAAC	ACAAGGGGCGCGACGGCGGCGAAGGGGAGCAGTCAGAA
GTTTGTATTTTACCTATGAGGAATTGAAAC	ATGCGTATGGCGTACGAAGCAGGAAAAGCTGGCGA
GTTTGTATTTTACCTATGAGGAATTGAAAC	CTTACATTCTGCTTTCTAGTAACCCACATGAGATTGC
GTTTGTATTTTACCTATGAGGAATTGAAAC	CTGTCTGTGCTGCTTGTGCTGCATCTGCAGCTGTAGC
GTTTGTATTTTACCTATGAGGAATTGAAAC	CGGGCATTGTGCCAAGCGTTAATGCCGACCAGTCCA
GTTTGTATTTTACCTATGAGGAATTGAAAC	TGCAACGCCCCATGCTTTTGTAGCTCCCGCGGCTAT
GTTTGTATTTTACCTATGAGGAATTGAAAC	CGGTAATGTGTACGCCCTCTACGTGTGGCATGCGC
GTTTGTATTTTACCTATGAGGAATTGAAAC	CACGTAAATACATTCATGCTATAATGAAATCAAGATAA
GTTTGTATTTTACCTATGAGGAATTGAAAC	CATCTATGCTATCTATGGTATAATAGAAGCATAAGGA
GTTTGTATTTTACCTATGAGGAATTGAAAC	GTTAGCTATGGCTTCTCTTTCCGCTTCCTCCTCCGT
GTTTGTATTTTACCTATGAGGAATTGAAAC	GGCTTTGACAGGGACATAATTCCTTAGATCGCTTGTA
GTTTGTATTTTACCTATGAGGAATTGAAAC	CGGGCATTGTGCCAAGCGTTAATGCCGACCAGTCC
GTTTGTATTTTACCTATGAGGAATTGAAAC	GAATACGACTTCGCATGTACTGCGTTTTCCATCGC
GTTTGTATTTTACCTATGAGGAATTGAAAC	CGCTTAAATATACGTACTCCGCCAAGTGACGCAGG
GTTTGTATTTTACCTATGAGGAATTGAAAC	CAATACATGGGCATGCCTAAAGGGAAGTTCCCAGTC
GTTTGTATTTTACCTATGAGGAATTGAAAC	CGGGACTGGTCCATTGGAGCATATAACCACAATTAT
GTTTGTATTTTACCTATGAGGAATTGAAAC	AAAGGGGTATGGGCCTACAAGAAATCCGGGTGTCAAG
GTTTGTATTTTACCTATGAGGAATTGAAAC	GTACGCCCGGTACGCATCCAAACCTATTGGGGTTTCC
GTTTGTATTTTACCTATGAGGAATTGAAAC

>NC_016023|11|3|2117433-2121795|CRT
GTTTGTATTTTACCTATGAGGAATTGAAAC	TAGGTTACCCGCTGTCACAAACCGGATCCGGAGACAAGC
GTTTGTATTTTACCTATGAGGAATTGAAAC	ATCGCGTCCGTGAGTTTGCCCCAGTATGCCGGGTTC
GTTTGTATTTTACCTATGAGGAATTGAAAC	AAGTGATGATCGCGACACATCCAGATGCCGATCATA
GTTTGTATTTTACCTATGAGGAATTGAAAC	AATGAGAAGATGGGAAGTACTTGCAATGCTAAACGG
GTTTGTATTTTACCTATGAGGAATTGAAAC	CGGTGTCGCCTTCCACGTCCAGCGCTAAAAATTTTGC
GTTTGTATTTTACCTATGAGGAATTGAAAC	TACCTCCCGGATTCAAATCCCTTTTTCTCGATCGCTG
GTTTGTATTTTACCTATGAGGAATTGAAAC	CGAGTGTAAACAGTGTAGACAGTACTTCCGTCTGCT
GTTTGTATTTTACCTATGAGGAATTGAAAC	TCTGACGGTCCGAGGGCTGCCCAACGGCACAAAGT
GTTTGTATTTTACCTATGAGGAATTGAAAC	GGGCAAAAATTTCACGAAACCGCTTTTGCATATTTCCCC
GTTTGTATTTTACCTATGAGGAATTGAAAC	GATTGTCTTCCAGAACCGCGTTTTCCCTCAATGTAGCCC
GTTTGTATTTTACCTATGAGGAATTGAAAC	CCTGATACTGGCGCTGTATACCAAATAGTTTCGCCT
GTTTGTATTTTACCTATGAGGAATTGAAAC	TCATTGAATATGATAAAATAAATGAATTGGATGTC
GTTTGTATTTTACCTATGAGGAATTGAAAC	AAGTTGTTGGTATGCGTGACGGCGATGATGTAACGGG
GTTTGTATTTTACCTATGAGGAATTGAAAC	ACACTAAACCGGTTAGCACGTCTACCACCAGTACAGT
GTTTGTATTTTACCTATGAGGAATTGAAAC	CACCATGCTTTCATGACCAAAAGTTTTGCGGATGAACC
GTTTGTATTTTACCTATGAGGAATTGAAAC	ACAGCATGACAGCTATCAATTCGCAAGCGATCAAAGAGC
GTTTGTATTTTACCTATGAGGAATTGAAAC	AGCGACAACGAACACAATAAGTCTGTATCATATCC
GTTTGTATTTTACCTATGAGGAATTGAAAC	ATTTTTAAACAGATCTGCTATCCCCGTGACCTGCTT
GTTTGTATTTTACCTATGAGGAATTGAAAC	TTCTGCTTCAGTATCTACATATGTACCAATGTATAA
GTTTGTATTTTACCTATGAGGAATTGAAAC	GCGTCTTGCTTTCGTTTCCATTCCACCATATTCGCG
GTTTGTATTTTACCTATGAGGAATTGAAAC	TTTTGGGGTGTGAGGCTGGCTGGGGGTGTGGGGGC
GTTTGTATTTTACCTATGAGGAATTGAAAC	GCGGTATGATGGATGGAGCAAGCCGACCCTCGGAGCT
GTTTGTATTTTACCTATGAGGAATTGAAAC	TTTGACGGACTCGTCGCAATGGATCCGCCTTTTTTCGT
GTTTGTATTTTACCTATGAGGAATTGAAAC	ACCAGGAACAGCTTGCTTTTGATTTGAATGTGTCCCC
GTTTGTATTTTACCTATGAGGAATTGAAAC	CAAGTATTTAAAAATCCACAACTGAATACAGAACG
GGTTGTATTTTACCTATGAGGAATTGAAAC	ATTCTTCGATGTCCTCCCTTAGCTGGTCCATCCCA
GTTTGTATTTTACCTATGAGGAATTGAAAC	CGGATATTGTAAAGGATGAACACACATATCATAAC
GTTTGTATTTTACCTATGAGGAATTGAAAC	TGAGGAGGGGGCTGATATGGTGAACGTTTCCTTTGA
GTTTGTATTTTACCTATGAGGAATTGAAAC	AAATACGGATAGGGTAACAAAAAAGGCGACCGCAAT
GTTTGTATTTTACCTATGAGGAATTGAAAC	CGTAATCCCCGACTTTCAGCTTCGGCGCCGTGTATT
GTTTGTATTTTACCTATGAGGAATTGAAAC	ATAGATTATGGTGTACCGGATGTACCGTTGGTAAAGGT
GTTTGTATTTTACCTATGAGGAATTGAAAC	CGGAAAGCCGTTAAAATTCTGCAAACTGTGCCGCCAC
GTTTGTATTTTACCTATGAGGAATTGAAAC	CTGTTCTTTTGGACTCTGTATATATTGGCCATGCTTT
GTTTGTATTTTACCTATGAGGAATTGAAAC	GCCGGTATTTCGTTTGATCGCACCGGATATGCAAC
GTTTGTATTTTACCTATGAGGAATTGAAAC	TCTGGCCCGAAAGCAATCTTCATTTTGACCACTTCT
GTTTGTATTTTACCTATGAGGAATTGAAAC	TACAAAATGGAGGTAAATGAATATGGCAAGTATACA
GTTTGTATTTTACCTATGAGGAATTGAAAC	ATCCGAGCCGTGATAAAATTGATACTCCCTTGCCAGTG
GTTTGTATTTTACCTATGAGGAATTGAAAC	TAACAATTGAGCCGTTTGGTATTGATCTCGAACTA
GTTTGTATTTTACCTATGAGGAATTGAAAC	AACGTAAATATCGCGCAGCTGGCGCTCAACAAGGCGC
GTTTGTATTTTACCTATGAGGAATTGAAAC	TCGGTAGTGGTAAAAGTTATCACGCTGTCAGAGACG
GTTTGTATTTTACCTATGAGGAATTGAAAC	TCGTATTTCACCTCGACATTAAACCGCGCTGGCTTTG
GTTTGTATTTTACCTATGAGGAATTGAAAA	AAAATAAGCATCGCAGTACATGGCGAGATGGCCGA
GTTTGTATTTTACCTATGAGGAATTGAAAC	TATAGCTGATGTCCGCATATAATTCATAGCTGTCGTCCGTTTGTATTTTACCTA
TTTTGTATTTTACCTATGAGGAATTGAAAC	AGCAGTGTAAACAAAAAAAAAGAAGGAGCTGAAAAG
GTTTGTATTTTACCTATGAGGAATTGAAAC	TTATTTCTGTAAACCGGCTTTCCATTTCTTCGTACACT
GTTTGTATTTTACCTATGAGGAATTGAAAC	TCGAAAAAGCAAGCGCAGGGCGTGCATGATGTCAT
GTTTGTATTTTACCTATGAGGAATTGAAAC	AGCGTAAATCAAAATATTATTTAATGATCGTGTAC
GTTTGTATTTTACCTATGAGGAATTGAAAC	ACAAGGGGCGCGACGGCGGCGAAGGGGAGCAGTCAGAA
GTTTGTATTTTACCTATGAGGAATTGAAAC	ATGCGTATGGCGTACGAAGCAGGAAAAGCTGGCGA
GTTTGTATTTTACCTATGAGGAATTGAAAC	CTTACATTCTGCTTTCTAGTAACCCACATGAGATTGC
GTTTGTATTTTACCTATGAGGAATTGAAAC	CTGTCTGTGCTGCTTGTGCTGCATCTGCAGCTGTAGC
GTTTGTATTTTACCTATGAGGAATTGAAAC	CGGGCATTGTGCCAAGCGTTAATGCCGACCAGTCCA
GTTTGTATTTTACCTATGAGGAATTGAAAC	TGCAACGCCCCATGCTTTTGTAGCTCCCGCGGCTAT
GTTTGTATTTTACCTATGAGGAATTGAAAC	CGGTAATGTGTACGCCCTCTACGTGTGGCATGCGC
GTTTGTATTTTACCTATGAGGAATTGAAAC	CACGTAAATACATTCATGCTATAATGAAATCAAGATAA
GTTTGTATTTTACCTATGAGGAATTGAAAC	CATCTATGCTATCTATGGTATAATAGAAGCATAAGGA
GTTTGTATTTTACCTATGAGGAATTGAAAC	GTTAGCTATGGCTTCTCTTTCCGCTTCCTCCTCCGT
GTTTGTATTTTACCTATGAGGAATTGAAAC	GGCTTTGACAGGGACATAATTCCTTAGATCGCTTGTA
GTTTGTATTTTACCTATGAGGAATTGAAAC	CGGGCATTGTGCCAAGCGTTAATGCCGACCAGTCC
GTTTGTATTTTACCTATGAGGAATTGAAAC	GAATACGACTTCGCATGTACTGCGTTTTCCATCGC
GTTTGTATTTTACCTATGAGGAATTGAAAC	CGCTTAAATATACGTACTCCGCCAAGTGACGCAGG
GTTTGTATTTTACCTATGAGGAATTGAAAC	CAATACATGGGCATGCCTAAAGGGAAGTTCCCAGTC
GTTTGTATTTTACCTATGAGGAATTGAAAC	CGGGACTGGTCCATTGGAGCATATAACCACAATTAT
GTTTGTATTTTACCTATGAGGAATTGAAAC	AAAGGGGTATGGGCCTACAAGAAATCCGGGTGTCAAG
GTTTGTATTTTACCTATGAGGAATTGAAAC	GTACGCCCGGTACGCATCCAAACCTATTGGGGTTTCC
GTTTGTATTTTACCTATGAGGAATTGAAAC

>NC_016023|11|3|2120310-2121795|PILER-CR
	TAGGTTACCCGCTGTCACAAACCGGATCCGGAGACAAGC
GTTTGTATTTTACCTATGAGGAATTGAAAC	ATCGCGTCCGTGAGTTTGCCCCAGTATGCCGGGTTC
GTTTGTATTTTACCTATGAGGAATTGAAAC	AAGTGATGATCGCGACACATCCAGATGCCGATCATA
GTTTGTATTTTACCTATGAGGAATTGAAAC	AATGAGAAGATGGGAAGTACTTGCAATGCTAAACGG
GTTTGTATTTTACCTATGAGGAATTGAAAC	CGGTGTCGCCTTCCACGTCCAGCGCTAAAAATTTTGC
GTTTGTATTTTACCTATGAGGAATTGAAAC	TACCTCCCGGATTCAAATCCCTTTTTCTCGATCGCTG
GTTTGTATTTTACCTATGAGGAATTGAAAC	CGAGTGTAAACAGTGTAGACAGTACTTCCGTCTGCT
GTTTGTATTTTACCTATGAGGAATTGAAAC	TCTGACGGTCCGAGGGCTGCCCAACGGCACAAAGT
GTTTGTATTTTACCTATGAGGAATTGAAAC	GGGCAAAAATTTCACGAAACCGCTTTTGCATATTTCCCC
GTTTGTATTTTACCTATGAGGAATTGAAAC	GATTGTCTTCCAGAACCGCGTTTTCCCTCAATGTAGCCC
GTTTGTATTTTACCTATGAGGAATTGAAAC	CCTGATACTGGCGCTGTATACCAAATAGTTTCGCCT
GTTTGTATTTTACCTATGAGGAATTGAAAC	TCATTGAATATGATAAAATAAATGAATTGGATGTC
GTTTGTATTTTACCTATGAGGAATTGAAAC	AAGTTGTTGGTATGCGTGACGGCGATGATGTAACGGG
GTTTGTATTTTACCTATGAGGAATTGAAAC	ACACTAAACCGGTTAGCACGTCTACCACCAGTACAGT
GTTTGTATTTTACCTATGAGGAATTGAAAC	CACCATGCTTTCATGACCAAAAGTTTTGCGGATGAACC
GTTTGTATTTTACCTATGAGGAATTGAAAC	ACAGCATGACAGCTATCAATTCGCAAGCGATCAAAGAGC
GTTTGTATTTTACCTATGAGGAATTGAAAC	AGCGACAACGAACACAATAAGTCTGTATCATATCC
GTTTGTATTTTACCTATGAGGAATTGAAAC	ATTTTTAAACAGATCTGCTATCCCCGTGACCTGCTT
GTTTGTATTTTACCTATGAGGAATTGAAAC	TTCTGCTTCAGTATCTACATATGTACCAATGTATAA
GTTTGTATTTTACCTATGAGGAATTGAAAC	GCGTCTTGCTTTCGTTTCCATTCCACCATATTCGCG
GTTTGTATTTTACCTATGAGGAATTGAAAC	TTTTGGGGTGTGAGGCTGGCTGGGGGTGTGGGGGC
GTTTGTATTTTACCTATGAGGAATTGAAAC	GCGGTATGATGGATGGAGCAAGCCGACCCTCGGAGCT
GTTTGTATTTTACCTATGAGGAATTGAAAC	TTTGACGGACTCGTCGCAATGGATCCGCCTTTTTTCGT
GTTTGTATTTTACCTATGAGGAATTGAAAC	ACCAGGAACAGCTTGCTTTTGATTTGAATGTGTCCCC
GTTTGTATTTTACCTATGAGGAATTGAAAC	CAAGTATTTAAAAATCCACAACTGAATACAGAACG
GGTTGTATTTTACCTATGAGGAATTGAAAC	ATTCTTCGATGTCCTCCCTTAGCTGGTCCATCCCA
GTTTGTATTTTACCTATGAGGAATTGAAAC	CGGATATTGTAAAGGATGAACACACATATCATAAC
GTTTGTATTTTACCTATGAGGAATTGAAAC	TGAGGAGGGGGCTGATATGGTGAACGTTTCCTTTGA
GTTTGTATTTTACCTATGAGGAATTGAAAC	AAATACGGATAGGGTAACAAAAAAGGCGACCGCAAT
GTTTGTATTTTACCTATGAGGAATTGAAAC	CGTAATCCCCGACTTTCAGCTTCGGCGCCGTGTATT
GTTTGTATTTTACCTATGAGGAATTGAAAC	ATAGATTATGGTGTACCGGATGTACCGTTGGTAAAGGT
GTTTGTATTTTACCTATGAGGAATTGAAAC	CGGAAAGCCGTTAAAATTCTGCAAACTGTGCCGCCAC
GTTTGTATTTTACCTATGAGGAATTGAAAC	CTGTTCTTTTGGACTCTGTATATATTGGCCATGCTTT
GTTTGTATTTTACCTATGAGGAATTGAAAC	GCCGGTATTTCGTTTGATCGCACCGGATATGCAAC
GTTTGTATTTTACCTATGAGGAATTGAAAC	TCTGGCCCGAAAGCAATCTTCATTTTGACCACTTCT
GTTTGTATTTTACCTATGAGGAATTGAAAC	TACAAAATGGAGGTAAATGAATATGGCAAGTATACA
GTTTGTATTTTACCTATGAGGAATTGAAAC	ATCCGAGCCGTGATAAAATTGATACTCCCTTGCCAGTG
GTTTGTATTTTACCTATGAGGAATTGAAAC	TAACAATTGAGCCGTTTGGTATTGATCTCGAACTA
GTTTGTATTTTACCTATGAGGAATTGAAAC	AACGTAAATATCGCGCAGCTGGCGCTCAACAAGGCGC
GTTTGTATTTTACCTATGAGGAATTGAAAC	TCGGTAGTGGTAAAAGTTATCACGCTGTCAGAGACG
GTTTGTATTTTACCTATGAGGAATTGAAAC	TCGTATTTCACCTCGACATTAAACCGCGCTGGCTTTG
GTTTGTATTTTACCTATGAGGAATTGAAAAAAAATAAGCATCGCAGTACATGGCGAGATGGCCGAGTTTGTATTTTACCTATGAGGAATTGAAACTATAGCTGATGTCCGCATATAATTCATAGCTGTCGTCCGTTTGTATTTTACCTATTTTGTATTTTACCTATGAGGAATTGAAACA	GCAGTGTAAACAAAAAAAAAGAAGGAGCTGAAAAGG
TTTGTATTTTACCTATGAGGAATTGAAACT	TATTTCTGTAAACCGGCTTTCCATTTCTTCGTACACTG
TTTGTATTTTACCTATGAGGAATTGAAACT	CGAAAAAGCAAGCGCAGGGCGTGCATGATGTCATG
TTTGTATTTTACCTATGAGGAATTGAAACA	GCGTAAATCAAAATATTATTTAATGATCGTGTACG
TTTGTATTTTACCTATGAGGAATTGAAACA	CAAGGGGCGCGACGGCGGCGAAGGGGAGCAGTCAGAAG
TTTGTATTTTACCTATGAGGAATTGAAACA	TGCGTATGGCGTACGAAGCAGGAAAAGCTGGCGAG
TTTGTATTTTACCTATGAGGAATTGAAACC	TTACATTCTGCTTTCTAGTAACCCACATGAGATTGCG
TTTGTATTTTACCTATGAGGAATTGAAACC	TGTCTGTGCTGCTTGTGCTGCATCTGCAGCTGTAGCG
TTTGTATTTTACCTATGAGGAATTGAAACC	GGGCATTGTGCCAAGCGTTAATGCCGACCAGTCCAG
TTTGTATTTTACCTATGAGGAATTGAAACT	GCAACGCCCCATGCTTTTGTAGCTCCCGCGGCTATG
TTTGTATTTTACCTATGAGGAATTGAAACC	GGTAATGTGTACGCCCTCTACGTGTGGCATGCGCG
TTTGTATTTTACCTATGAGGAATTGAAACC	ACGTAAATACATTCATGCTATAATGAAATCAAGATAAG
TTTGTATTTTACCTATGAGGAATTGAAACC	ATCTATGCTATCTATGGTATAATAGAAGCATAAGGAG
TTTGTATTTTACCTATGAGGAATTGAAACG	TTAGCTATGGCTTCTCTTTCCGCTTCCTCCTCCGTG
TTTGTATTTTACCTATGAGGAATTGAAACG	GCTTTGACAGGGACATAATTCCTTAGATCGCTTGTAG
TTTGTATTTTACCTATGAGGAATTGAAACC	GGGCATTGTGCCAAGCGTTAATGCCGACCAGTCCG
TTTGTATTTTACCTATGAGGAATTGAAACG	AATACGACTTCGCATGTACTGCGTTTTCCATCGCG
TTTGTATTTTACCTATGAGGAATTGAAACC	GCTTAAATATACGTACTCCGCCAAGTGACGCAGGG
TTTGTATTTTACCTATGAGGAATTGAAACC	AATACATGGGCATGCCTAAAGGGAAGTTCCCAGTCG
TTTGTATTTTACCTATGAGGAATTGAAACC	GGGACTGGTCCATTGGAGCATATAACCACAATTATG
TTTGTATTTTACCTATGAGGAATTGAAACA	AAGGGGTATGGGCCTACAAGAAATCCGGGTGTCAAGG
TTTGTATTTTACCTATGAGGAATTGAAACG	TACGCCCGGTACGCATCCAAACCTATTGGGGTTTCCG
TTTGTATTTTACCTATGAGGAATTGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_016023.1\|WP_013860391.1\|2128919_2129540_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
NC_016023.1\|WP_014097197.1\|2109349_2110306_+\|type-I-CRISPR-associated-protein-Cas7	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	gnl\|CDD\|377458
NC_016023.1\|WP_014097195.1\|2106531_2107287_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	gnl\|CDD\|187889
NC_016023.1\|WP_014097205.1\|2122074_2123538_-\|transposase	unknown	unknown	gnl\|CDD\|376573
NC_016023.1\|WP_014097200.1\|2113371_2113881_+\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
NC_016023.1\|WP_014097198.1\|2110318_2111008_+\|CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	gnl\|CDD\|131641
NC_016023.1\|WP_014097211.1\|2131648_2132794_+\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|236506
NC_016023.1\|WP_181980972.1\|2127250_2127526_+\|hypothetical-protein	unknown	unknown	unknown
NC_016023.1\|WP_014097199.1\|2110995_2113359_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|224124
NC_016023.1\|WP_014097196.1\|2107338_2109363_+\|hypothetical-protein	cas8b1	mkCas0074_cas8b1_CAS-I-B	unknown
NC_016023.1\|WP_014097209.1\|2127646_2128066_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NC_016023.1\|WP_014097202.1\|2114199_2115558_+\|IS1182-like-element-ISBco4-family-transposase	unknown	unknown	gnl\|CDD\|376573
NC_016023.1\|WP_014097203.1\|2115620_2116451_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|274695
NC_016023.1\|WP_179234616.1\|2124789_2125903_+\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|222853
NC_016023.1\|WP_014097213.1\|2134136_2135051_+\|DUF1002-domain-containing-protein	unknown	unknown	gnl\|CDD\|377628
NC_016023.1\|WP_014097204.1\|2116460_2116724_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NC_016023.1\|WP_014097194.1\|2102800_2106046_+\|SNF2-helicase-associated-domain-containing-protein	unknown	unknown	gnl\|CDD\|223627
NC_016023.1\|WP_014097212.1\|2132949_2133801_-\|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224651
NC_016023.1\|WP_014097214.1\|2135073_2135979_-\|hypothetical-protein	unknown	unknown	unknown
NC_016023.1\|WP_013860389.1\|2130120_2131422_+\|cation:dicarboxylase-symporter-family-transporter	unknown	unknown	gnl\|CDD\|183075

Protein	Function_ID	Function_description	E-value
NC_016023.1\|WP_013860391.1\|2128919_2129540_-\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	1.3128e-70
NC_016023.1\|WP_014097197.1\|2109349_2110306_+\|type-I-CRISPR-associated-protein-Cas7	gnl\|CDD\|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	4.05555e-74
NC_016023.1\|WP_014097195.1\|2106531_2107287_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|187889	cd09759, Cas6_I-A, CRISPR/Cas system-associated RAMP superfamily protein Cas6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas6 is an endoribonuclease that generates crRNAs, predicted subunit of Cascade complex; RAMP superfamily protein; Possesses double RRM/ferredoxin fold.	1.4264e-36
NC_016023.1\|WP_014097205.1\|2122074_2123538_-\|transposase	gnl\|CDD\|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	5.90997e-05
NC_016023.1\|WP_014097200.1\|2113371_2113881_+\|CRISPR-associated-protein-Cas4	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	1.90267e-68
NC_016023.1\|WP_014097198.1\|2110318_2111008_+\|CRISPR-associated-protein-Cas5	gnl\|CDD\|131641	TIGR02592, hypothetical_protein_CTC_01466, CRISPR-associated protein Cas5, subtype I-B/HMARI. This is a CRISPR-associated protein unique to the hmari subtype of cas genes and CRISPR repeat, which is the only subtype present in Haloarcula marismortui ATCC 43049. The hmari type, though uncommon, is also found in the Aquificae, Thermotogae, Firmicutes, and Dictyoglomi.	2.70428e-21
NC_016023.1\|WP_014097211.1\|2131648_2132794_+\|metallophosphoesterase	gnl\|CDD\|236506	PRK09420, cpdB, bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase.	5.49678e-154
NC_016023.1\|WP_014097212.1\|2132949_2133801_-\|MurR/RpiR-family-transcriptional-regulator	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	3.71174e-75
NC_016023.1\|WP_014097199.1\|2110995_2113359_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	1.99084e-37
NC_016023.1\|WP_014097209.1\|2127646_2128066_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	8.63089e-16
NC_016023.1\|WP_014097202.1\|2114199_2115558_+\|IS1182-like-element-ISBco4-family-transposase	gnl\|CDD\|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	2.73912e-15
NC_016023.1\|WP_014097203.1\|2115620_2116451_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274695	TIGR03641, cas1_HMARI, CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes Cas1 subgroup that includes Cas1 proteins of the related HMARI and TNEAP subtypes of CRISPR/Cas system.	2.08322e-132
NC_016023.1\|WP_179234616.1\|2124789_2125903_+\|IS3-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	3.74282e-41
NC_016023.1\|WP_014097213.1\|2134136_2135051_+\|DUF1002-domain-containing-protein	gnl\|CDD\|377628	pfam06207, DUF1002, Protein of unknown function (DUF1002). This protein family has no known function. Its members are about 300 amino acids in length. It has so far been detected in Firmicute bacteria and some archaebacteria.	7.04591e-83
NC_016023.1\|WP_014097204.1\|2116460_2116724_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	1.23108e-30
NC_016023.1\|WP_014097194.1\|2102800_2106046_+\|SNF2-helicase-associated-domain-containing-protein	gnl\|CDD\|223627	COG0553, HepA, Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair].	3.31869e-101
NC_016023.1\|WP_013860389.1\|2130120_2131422_+\|cation:dicarboxylase-symporter-family-transporter	gnl\|CDD\|183075	PRK11283, gltP, glutamate/aspartate:proton symporter; Provisional.	0

>NC_016023.1|WP_014097204.1|2116460_2116724_+|CRISPR-associated-endonuclease-Cas2
MFIIVVYDFGVKRVAKALKTTRKYLNWVQNSVFEGEISNANYVKLKKELQALMNPEEDSVIFYTFRTKRYSKREEFGLKKGGDENII
>NC_016023.1|WP_014097203.1|2115620_2116451_+|type-I-B-CRISPR-associated-endonuclease-Cas1
MKLIHYFNHYGYYVGTFYPREHQNAGHIILKQAEHYLDNGKRLLLAKTFISGSIAQMGQVLKYYRTRVAKGKEEIENLLEQFNGNIKELEKGNTVEELMAVEGHSREEYYKMFDFITSNPDFVFEKRSRRPPLNRLNALISFGNSICYTTVLSEIYKTYLDPRIGYLHTTNFRRFSLNLDVAEIFKPIMVDRLIFTMINKKMLTKKDFDKHTEGITLSEAGRRKFVAELDKRMKTTVNHRHLGRTVSYRRLIRLELYKIQKHVMEEGNYVPYHSLW
>NC_016023.1|WP_014097202.1|2114199_2115558_+|IS1182-like-element-ISBco4-family-transposase
MTIIRQISFFGIQELYEMEPTHRYDAIISAINLDKICHAISKKSNLGAPEALNYAAMVISVFIRIVERIPTIKDLVKRLNEDIAFKLNCGFLVSDHIPSEASYSRLITKLEETNILEVSLKEVITQAISEGFIMDDTVAIDATHFEARDQAPPKKEKPDKEPKKRGRKPKEEREKWLAEQAEKEANLPIYEKKIEAQLDAPLDELRSQVPIDPKWGIKKNSEGKNVFWFGYKGHLAVGASSQYILQTLFSSGNLNDGKAAIPLLKGIQQRLNLPALHYTTMDAGYDYEPIYQQVYRMGCQSVIAYNKRNEPELEGFDKHFALTCFREYSYRYDSYDAKYETLKYTRPKECADCPLANEGICQKVYKVKITTDLRKYTAPARGSKAWKNIFKRRTAVERVNAYLKEFFQLNNVRYRTGKRAKVHFDLVTLIYNASKLAADRINAMIKQTQQAA
>NC_016023.1|WP_014097200.1|2113371_2113881_+|CRISPR-associated-protein-Cas4
MGYEMPVTGTDIWYYFICKRESWLMSHKITPDEEDENIEIGRFIHEYRYKREKQETAIDTIKLDRIKKVNGKLVVQEIKKSSRFETSARYQLLYYLDTLKQMGIEATGELLFPEERKKEMVEWTPEEKSVLDQAVEEIRKIAKMPVPPKPNKIKFCGKCAYKEFCWAGE
>NC_016023.1|WP_014097199.1|2110995_2113359_+|CRISPR-associated-helicase/endonuclease-Cas3
MPVLVPFDKCIARPDEEGKKHLLKNHLLRVKEFAENWISDTGEPVKELIGLAAICHDIAKSHADWQRYILDPEIKKGPTHAPQGAFLFSFLGYHWLEITRQWEAYRVVWLWLVRDIADHHGKLKKLQDDNWLQRYDWEKMDFEGISSFLKDHYPEFSGLELTIDSMDDWLDVADEQIEEAMDDLDTGFGQKKDFDLMVHLQAWRALTTALIAGDRFDVKDTGTSWFDEKTIEKCEAALGRYCTAKAGSPLAQARSQAQKNIIKQMAEQPASWFYTLELPTGYGKTITALKLSLWLGKQRHYRKIVYVAPYLSILEQTSRVIGEAMDIGALEHHSLAILDQSNKSGTQGEQRAPNDELAMESWAHSVICTSFQQWSKAIFPGRAQDVLRRSFLKDSIIIIDEPQIFNPDGWNLFLTGLEAIAKQQHLCVLFLSATMPPFEYGLSRKPIRLAASGSQVERYQVRLEEKMDEEKMAAFLNDREDIKQAAILNTIEDAYRVYKQINGEEDVRLLHGLMVPVHKKLEIAKIQDHLEKEKEKRLIVIATQIIEAGVDVSFHHVIRALPILPSIVQAAGRVNRHFETDNGILTIAPFFRNGEKNTRNSIYARPLQRITDRLLFEKDIWLESEMEPLVRRYYEEMFRENTYETAKQAIREAYEGDWPQLSKYEPFGQDYLKLPLFVPWEVPEEDEKWLPEQFLWLRKKFGVTDAASIYERYSNVNFMNGLSFEERKQFMILFHHFVLNVPVKTALRFVSQEEYLQSNRVPLLYSEGAYDQNLGLVGHFDELDNFI
>NC_016023.1|WP_014097198.1|2110318_2111008_+|CRISPR-associated-protein-Cas5
MEAVVFDLKSDLAHFRRPDTTSTQLTYPFISPTAVKGIAGAILGIEDFTTRDKIGIQLLHPVKTVSQQMSMLGKDSGSTFNRPTTVELVVKPFYRIYYAGDEYVRDLYRFLSKGRAVYPTYLGSAYALTKPVLQAYYEQVEPLREWSEPLRTRCVVPTRLVKEMKFEPERYYSRAGGFMLVYKGSREFEKSIDFVYERNGDAITFLPDKRQISDELQIVQIGDETVCLF
>NC_016023.1|WP_014097197.1|2109349_2110306_+|type-I-CRISPR-associated-protein-Cas7
MPVRNGELLFIKSVKDGIPNRDPLNDSDARRIFPEEDGRISLSDVSIKRDVRDFVIDYQADGGSQQKNYIFVQEKFNEKGKLLGRGSLAEGIAKAVGKEKESKTDMKSVLLEHSFDVRTFGVVYSVKPKFNLTGPVQFGWAHSMHPVDSQYVQGTVVMPSTDSKGDEEGKTQGTIWTSYTVPFAVFAMPGIINAKNAEHSQMTEEDQELLLRALWQGTQHRQARGRGQQQPLLLAHIEYKDPFYRIGYLEDLVSLKPGEETWRNEGRRPSSLKDITLDLTELLKTIEEQQDKIARCRIWLHPSAQIEGEISKYQSPLW
>NC_016023.1|WP_014097196.1|2107338_2109363_+|hypothetical-protein
MLAESIIRIGRPIANSPDLPVKERIRWLTDVESENCKNFFQNVLIVELGNVGDALSYVTVGKAGEGKKSFIVDANQSTSFPILYPNGGNPLKAQGVYPVPCYLMYEPHMKAMAEKEQFYQALLPRLKKTVGYMKLGIEEIEAVAGRVSEILEAHHTDFLTEEKQLGILMIYDERLPVYLKLSGKSDNPDELWIRESRLEPGKQLYLNGREALQGIIDAKFDEASTLGKEHNAVSTFTNQKTEEVVSVYNKSWLWLSPTWEMPKSIYWGKDEWTKGIKVDKKSYESYLYGTQFLKKIQVPLSNTVLKEMFSPISSVEAKKHMRAGSFEQIFGIPMVLPLLDEDSEQYYQKFLRILRTNQDLKEEDLHLELLAGMKQSIVPRSSDQYRLTILYYSGDLSRGSMHIRAVIEDVIPSVAYEVQNIIKQLRRRHLGQIQAVFELEQRPFFRVESLPSILANAYGPGYVWSTMQAVLHREPLTLERAVSATAKRLNELANKESYWEMKQELVFFYSFVFFLNRYNEKILAKGKDVKELADWKAMIEKYHAGSVELEDLHNAETLGFVSGLLLKQFSNSYYKKTGKDYVKHRVMKFGSKLTPEMIWKYGTLRCEELAQQWDLNISKNFHAVLAQVLLGFIEADKENLLISQKDAFMTAFWSGYLSYKSNKKQEGEEINAGA
>NC_016023.1|WP_014097195.1|2106531_2107287_+|CRISPR-associated-endoribonuclease-Cas6
MKLIVTFSANDNALKLPLNYQQMLQGFIYRNLLDPDFSRFLHNHGFLNGKRIFKLFVFSQLFGKYSLLKETKEIVFKGPVTWHVGSVVPEFIKGFGRSLLTSGHLELNGQEMKVEEVTYRQDTPESEKCRIRMLSPITVYSTYQNQNGKKITQYFDPKDPAFTYLVEENIKKKYAAFYQKDTQDLFFKIQPVRVTEKDKRITRYKGFIINGWGGIYVIEGSPNLLSFAESTGLGSKNSQGFGMFEVIHQQL
>NC_016023.1|WP_014097194.1|2102800_2106046_+|SNF2-helicase-associated-domain-containing-protein
MVELLLFEEDVEDMYSPAIFRRGMRYYLEGRVKKLIPDSTMEFTWTAIVKGSKTYYVTVRYDEEFGGFANECTCPAFAQYGECKHEVAAMLAIANREEEVAEPDIGDVPEMHQNMKTLQLMNIFSGLQQSMMETKHHAARKPLRLEYFLKATNISGFGSDHFLTIEFKIGPGRTYVVRNIKEFLGHVSHGNPHEFTKNFTYDPDEYEFEKEDHEIVEMLLFMLSTQQLYEASIDNWYRYTFERELVIPPFIARPLIEKLANRKCKFEYGRYASDSITVQPGEELPLSFRLDGNRQGGPGFSLQLKSLRDLLLFEQYGLAFYKGVFYETPDEQLVLLKALEDFNKNSGDEVEIRQEQISPFLSNVLPGLKRIGKVKLTNEIKGKIVQPKLQTKIFMDNEDEKITLRIEHHYGSRVIDPFTDEETADDDKILLRDVEKEQKIMTMIEQSPLKYNGKQLYLEDDEEALYEFIFTILPQLEEEAEVYIAGGIKSYFQTSRYTPVTSVDMDTSGSFLEVNFDMDGIDEEEIRNVLRSVIEKKRYYRLPDGAFVSLESDAFEHIGQLLEELHVPKKELEDNRLKVPVYRGLQVEELMKTRDKYAVKFGKAFRKLVQQLKNPEDTDFELPKGLQAKMRDYQVTGFQWFKSLAFYRLGGILADDMGLGKTLQSISYMLSEKEANSDIKPFLVVAPASLIYNWKSEIEKFAPGLSSMVIAGTPSERKAFFEAGELPDVLITSYPTLRQDIGEYEKIEFDTLILDEAQAIKNYATKTAAAVRNVQAGRRFALSGTPIENSIDELWSIFQAVLPGFFPPLSEFRKMEQEKISRMVRPFILRRVKKDVLKELPDKIETNQLSELTKPQKELYLAYLDRIRHETAQTLAEGDFNRNRIKILAGLTRLRQLCCHPALFVENYRGESGKLEQLVELAHTAIENGKRLLIFSQFSSMLQLIRTRLSDEGIDSFYLDGQTPSRERVEMADRFNSGEKNVFLISLKAGGTGLNLTGADTVVLYDLWWNPAVEEQAAGRAHRIGQKNVVQVIRLIARGTIEEKIYELQQKKKELIEKVIQPGETMLNSLNEEEIKELLGM
>NC_016023.1|WP_014097205.1|2122074_2123538_-|transposase
MTISILTQTRDFSIQQNLIPHNWQDYADIPFVIPAMCFPWEIFKPIEREYYTLLYLHLKNERAHDPSNEIQPALFSITEEEDKSASSLFHLPSTGRKPHPFMPFFRAFELASLQYIEVMVESVYLQVKSNPLFATMCGFTEKIPSYRSFARFDQIMTTNGLWEKARLLVVEYNKGEGVVETNEEAAAVDTSHIEAEATLNKTRKTCSCEGDCDCPKVLTDDNVGVMRKSNAVSYIAHKLSMVCGVRSGLPLTREVFKGNTPDGKTLEPTLETFKAEHPEMAEQLSFILADGIYQTPENQKVTKDVLQAKLVAPINPRNRKDKPTTARGIEKINRYGTPICISGHKMELRGSDREKGQYIYTCPVFHPNAKQEGLTCPLANHAECCNGAAQGRVFRMDFDQTPQVDVELPQHGRTFEVLYSARTIIERIFGILKDGYSLRRVHKRGKQAVEAHVDRCMISMHIMANMAYHQTGKANCGWTRNRLQRAN
>NC_016023.1|WP_179234616.1|2124789_2125903_+|IS3-family-transposase
MRKSYTPEFKTQVVLEVLKEEKTMNEIASAHGIHVNQIRQWRNAFLEQMPKVFEKGNKKVEKMKAEYEQTIESLYAEVGRLTTQLSWLKKKNLELRSRAERVEMVDWDDEAKLPISIQADLLSLNRSSLYYKPVGPSPEELFIKHRIDEIYTKHPYYGSRRIAALLNAEGLVINRKAVQRHMREMGIAGITPGPNLSKRSLEHRIYPYLLRNLKITHPNHVWGIDITYIRLQKSWMYLVALIDWYSRYVVSWEIDQTLEIDFVLEAVKRAFLVARPEILNSDQGSHFTSPKYTDLVLENTIKISMDGKKRALDNIITERLWRTIKYEEVYLKEYNSPREARKEIGNFIQFYNHERLHQALGYKTPASVYGL
>NC_016023.1|WP_181980972.1|2127250_2127526_+|hypothetical-protein
MVYRIVLFLLPEVLPVIIPVPTVPCSLACSCLARKKRAQVPPAGIIKQKQAALPKKDFKVFPIEGLLSEPDKALSLVRSAAKLVDAAFFFL
>NC_016023.1|WP_014097209.1|2127646_2128066_-|helix-turn-helix-transcriptional-regulator
MADHGNENMDNVKAIFAARLKKVRAAQGYSQPELAKRVGVSDRNISNYETGYSFPSIKVLYRISQVLKVSIDYLLGLTNHVGLKTNEAVSNPEKKLLETLSHEPDLYQMMLKDPEKMANRIYQTWNLIRELDDEDDKNT
>NC_016023.1|WP_013860391.1|2128919_2129540_-|histidine-phosphatase-family-protein
MTLFYFVRHGQTEWNADRNRYCGRSDIGLSETGVRQAKLAAGFLKDIPFDAVYASTLGRAVRTAEILVKGRNLEIHQDPRLVETDFGAWEGERQEDFSVNYADNWEAWLQDPGATHAGYTGETAVQVYNRVRACINELVEKHPEETVLVVAHSMAIRFFVAGTLEVPFKNYRMIPQDNTGITIYKEAPENAGFLAINLNTHLYAIK
>NC_016023.1|WP_013860389.1|2130120_2131422_+|cation:dicarboxylase-symporter-family-transporter
MKRVSLAWQIFIGLILGIAIGGIFHGNDTVAHILQPFGDFFLRLIKMIVIPIVVSSLIVGVAGAGDMKQVGKLGLKALIYFEIVTTIAIVVGLLAGNLFHPGTGVDMGSLAKTSISSYVETTKETQHNGIVDTILNIVPTNLFESLSQGNMLPIIFFSVMFGIGVAAIGEKGKPVLRFFQGVSEAMFYVTNLVMKVAPIGVFGLIGVTVAQFGLKSLIPLSKLVFTVYGTIIFFVVVVLGLIGWLFRVNIFKLFKILKDELILAYSTASSEAVLPRLMEKMEKFGCPKSITTLVIPTGYSFNLDGSTLYQSLAALFIAQMYGIHMSIGAQISLVLVLMVTSKGIAGVPGVSFVVLLATLGTVGIPIEGLAFIAGIDRILDMARTVCNVVGNTLATIIVSKWEGKYDKEKGEAYLAEISGGGHDSKDHKYVTES
>NC_016023.1|WP_014097211.1|2131648_2132794_+|metallophosphoesterase
MGKKMLLWAAVLSLALFPRTEHADAAFWFQPKRATVDLRLLETSDLHGYMLNYDYAARTEAETYGLALTASLIAAERKAAKNTMLFDDGDLLEGSEMAAYAARRPLKKGEIHPFIRVMNHLNYDAATVGNHDFHYGLDFLKQTISGAKFPFVNANIYYNFEKNDTDDQNFFKPYVILNKKVEDRHGHSHHLKIGVIGFVTPSVIEWEKPSLGGKVKAKDILHTAAWFVPRMKAEGADLIIALAHCGVDPAAKQPFYTGDAVYLLSEVKGIDAILFGHQHRVFPSEFFAGVPGVDIRKGTINGVPAVMPGKWGSHLGVISLTLEKKGEKWEMTEAQSEAKPVYATHNQQAKSIVRPDPDIVRMTAELQKNVLGSKFTLYSRN
>NC_016023.1|WP_014097212.1|2132949_2133801_-|MurR/RpiR-family-transcriptional-regulator
MGTQLQSFPCLHRIQTMYSEFSAKERKIADYILENPQRLVHSTINQVADQLLVADATVFRFCKRIGFSGFQALKIALAAEAARPGKNMDEAVKDTDNEKAVAIKVFESNIETLQDTIHTLNQKHLHEAVEWICRAKHIVFYGCGSASVIALDALEKFLQTDLAVTAYTDPHLQLLSAARCTKEDVAVFISHAGADKEMLKLLQAVQKTGAKTIAITQFAKSPLSQKADVPLFTVSQEADFRFSSFSARIVQLSLIDTLYVNVMLRYKDTNEEILQKGKETYTV
>NC_016023.1|WP_014097213.1|2134136_2135051_+|DUF1002-domain-containing-protein
MLKRLGLIWFIAMIALGFSMNGVAKASGDNSTVIDEKYGKPIVVTGAALSASQKAEVEKELGVDDANNVEEITVTGDDLVHYIPDGNRNSNMYSSAKITRTDSGGVQVNIVTPENITEVTADMYKNALLTAGIKNAEVEVASPLKVTGHSALVGIYKAYDDSSKSGDKLDSDRTEVASQELSVATDLAKKEGLSNDKVTQLLTEIKQEIADQHPATKEDIEKIVDDKLKDLNINLSDSDRQLLYDLFDQMRKLNINFDSVKSELSSLSDKLSDKINKAAGDKGFWQSVKDFFQNIFDAIRGLFQ
>NC_016023.1|WP_014097214.1|2135073_2135979_-|hypothetical-protein
MVRQVKKTKSFLLTAVFIAFNFCFFTNISVAESPATDGFIIEADRVEGVMLPPGITAGDTATKQNQVMLRLQYADVTIYGLKITKVLQTPGGPVTIHMNAPGPIQLKNMKADATKVDFGSIYVPEKAGQIGMKNVRLVAHQQLADNADLPGLDLSMETGAANFDTSGSDEETLRKQADQLTQLLKGGTPEQNKEEKNGKSDTADKAKADTQDKAKTETQDTKKQHDAKTDGKVTDQNKNKKSENADDTKTKNAEETKSDNTGTKPASGQGTEQNGTPAKTAPGQSSTDKNVQQKEGSSAGN

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Crispr_ID: NC_016023_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016023_12

2123872-2124703

TypeI-B

Consensus_repeat	Method
GTTTGTATTTTACCTATGAGGAATTGAAAC	CRISPRCasFinder
GTTTGTATTTTACCTATGAGGAATTGAAAC	CRT
GTTTCAATTCCTCATAGGTAAAATACAAAC	PILER-CR

12 spacers

cas2,cas1,cas4,cas3,cas5,cas7b,cas8b1,cas6

The CRISPR arrays of NC_016023_12

>merge|NC_016023|12|2123872-2124703|CRISPRCasFinder,CRT,PILER-CR
CAAGGGCTCTTACCTATGAGGAATTGAAACACCAACAAAATGCAGGCGGTCGAAACGGGGCAGCTGCGTTTGTATTTTACCTATGAGGAATTGAAACATAAAACAAAAACAGTAAAGAAAATTGAGAAGCGTGTTTGTATTTTACCTATGAGGAATTGAAACAATAAGCTGCTGGAACACACGCTGAACATAAAGCGAGTTTGTATTTTACCTATGAGGAATTGAAACTCATAATAAGTGACGACGGGCATTGTCACGCCGTCAAGCGTTTGTATTTTACCTATGAGGAATTGAAACATAAATGTATAATGTGTGCCATATTGATTAGTATGTGTTTGTATTTTACCTATGAGGAATTGAAACCAGCCTGTATATTCCTAGGATCACATACATAATCCCAGTTTGTATTTTACCTATGAGGAATTGAAACCGAGTTCGCGAAGTTCGGCCGTCGTTTTGGTGCTGGATGTTTGTATTTTACCTATGAGGAATTGAAACGTCTTGGTTTTTGGGATGTCTGGCATGTCAAATGTACCGTTTGTATTTTACCTATGAGGAATTGAAACAGGAATACTCCAGCCTCGATGTGGTCATTGGTGCTTTGTTTGTATTTTACCTATGAGGAATTGAAACCATTATACCACCCCATATAAAATAAAGGGGTAGCGACGTTTGTATTTTACCTATGAGGAATTGAAACAGGCGGGAGCGCCCCTCGGTCAAAAACTCATCTAAGTTTGTATTTTACCTATGAGGAATTGAAACAAAGGCCATCACCCTGGTATCCCCCTTTGGTACGCCCGTTTGTATTTTACCTATGAGGAATTGAAAC

>NC_016023|12|11|2123872-2124703|CRISPRCasFinder
CAAGGGCTCTTACCTATGAGGAATTGAAAC	ACCAACAAAATGCAGGCGGTCGAAACGGGGCAGCTGC
GTTTGTATTTTACCTATGAGGAATTGAAAC	ATAAAACAAAAACAGTAAAGAAAATTGAGAAGCGT
GTTTGTATTTTACCTATGAGGAATTGAAAC	AATAAGCTGCTGGAACACACGCTGAACATAAAGCGA
GTTTGTATTTTACCTATGAGGAATTGAAAC	TCATAATAAGTGACGACGGGCATTGTCACGCCGTCAAGC
GTTTGTATTTTACCTATGAGGAATTGAAAC	ATAAATGTATAATGTGTGCCATATTGATTAGTATGT
GTTTGTATTTTACCTATGAGGAATTGAAAC	CAGCCTGTATATTCCTAGGATCACATACATAATCCCA
GTTTGTATTTTACCTATGAGGAATTGAAAC	CGAGTTCGCGAAGTTCGGCCGTCGTTTTGGTGCTGGAT
GTTTGTATTTTACCTATGAGGAATTGAAAC	GTCTTGGTTTTTGGGATGTCTGGCATGTCAAATGTACC
GTTTGTATTTTACCTATGAGGAATTGAAAC	AGGAATACTCCAGCCTCGATGTGGTCATTGGTGCTTT
GTTTGTATTTTACCTATGAGGAATTGAAAC	CATTATACCACCCCATATAAAATAAAGGGGTAGCGAC
GTTTGTATTTTACCTATGAGGAATTGAAAC	AGGCGGGAGCGCCCCTCGGTCAAAAACTCATCTAA
GTTTGTATTTTACCTATGAGGAATTGAAAC	AAAGGCCATCACCCTGGTATCCCCCTTTGGTACGCCC
GTTTGTATTTTACCTATGAGGAATTGAAAC

>NC_016023|12|4|2123872-2124703|CRT
CAAGGGCTCTTACCTATGAGGAATTGAAAC	ACCAACAAAATGCAGGCGGTCGAAACGGGGCAGCTGC
GTTTGTATTTTACCTATGAGGAATTGAAAC	ATAAAACAAAAACAGTAAAGAAAATTGAGAAGCGT
GTTTGTATTTTACCTATGAGGAATTGAAAC	AATAAGCTGCTGGAACACACGCTGAACATAAAGCGA
GTTTGTATTTTACCTATGAGGAATTGAAAC	TCATAATAAGTGACGACGGGCATTGTCACGCCGTCAAGC
GTTTGTATTTTACCTATGAGGAATTGAAAC	ATAAATGTATAATGTGTGCCATATTGATTAGTATGT
GTTTGTATTTTACCTATGAGGAATTGAAAC	CAGCCTGTATATTCCTAGGATCACATACATAATCCCA
GTTTGTATTTTACCTATGAGGAATTGAAAC	CGAGTTCGCGAAGTTCGGCCGTCGTTTTGGTGCTGGAT
GTTTGTATTTTACCTATGAGGAATTGAAAC	GTCTTGGTTTTTGGGATGTCTGGCATGTCAAATGTACC
GTTTGTATTTTACCTATGAGGAATTGAAAC	AGGAATACTCCAGCCTCGATGTGGTCATTGGTGCTTT
GTTTGTATTTTACCTATGAGGAATTGAAAC	CATTATACCACCCCATATAAAATAAAGGGGTAGCGAC
GTTTGTATTTTACCTATGAGGAATTGAAAC	AGGCGGGAGCGCCCCTCGGTCAAAAACTCATCTAA
GTTTGTATTTTACCTATGAGGAATTGAAAC	AAAGGCCATCACCCTGGTATCCCCCTTTGGTACGCCC
GTTTGTATTTTACCTATGAGGAATTGAAAC

>NC_016023|12|4|2123939-2124703|PILER-CR
GTTTGTATTTTACCTATGAGGAATTGAAAC	ATAAAACAAAAACAGTAAAGAAAATTGAGAAGCGT
GTTTGTATTTTACCTATGAGGAATTGAAAC	AATAAGCTGCTGGAACACACGCTGAACATAAAGCGA
GTTTGTATTTTACCTATGAGGAATTGAAAC	TCATAATAAGTGACGACGGGCATTGTCACGCCGTCAAGC
GTTTGTATTTTACCTATGAGGAATTGAAAC	ATAAATGTATAATGTGTGCCATATTGATTAGTATGT
GTTTGTATTTTACCTATGAGGAATTGAAAC	CAGCCTGTATATTCCTAGGATCACATACATAATCCCA
GTTTGTATTTTACCTATGAGGAATTGAAAC	CGAGTTCGCGAAGTTCGGCCGTCGTTTTGGTGCTGGAT
GTTTGTATTTTACCTATGAGGAATTGAAAC	GTCTTGGTTTTTGGGATGTCTGGCATGTCAAATGTACC
GTTTGTATTTTACCTATGAGGAATTGAAAC	AGGAATACTCCAGCCTCGATGTGGTCATTGGTGCTTT
GTTTGTATTTTACCTATGAGGAATTGAAAC	CATTATACCACCCCATATAAAATAAAGGGGTAGCGAC
GTTTGTATTTTACCTATGAGGAATTGAAAC	AGGCGGGAGCGCCCCTCGGTCAAAAACTCATCTAA
GTTTGTATTTTACCTATGAGGAATTGAAAC	AAAGGCCATCACCCTGGTATCCCCCTTTGGTACGCCC
GTTTGTATTTTACCTATGAGGAATTGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_016023.1\|WP_013860391.1\|2128919_2129540_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
NC_016023.1\|WP_014097197.1\|2109349_2110306_+\|type-I-CRISPR-associated-protein-Cas7	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	gnl\|CDD\|377458
NC_016023.1\|WP_014097205.1\|2122074_2123538_-\|transposase	unknown	unknown	gnl\|CDD\|376573
NC_016023.1\|WP_014097195.1\|2106531_2107287_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	gnl\|CDD\|187889
NC_016023.1\|WP_014097200.1\|2113371_2113881_+\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
NC_016023.1\|WP_014097198.1\|2110318_2111008_+\|CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	gnl\|CDD\|131641
NC_016023.1\|WP_014097211.1\|2131648_2132794_+\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|236506
NC_016023.1\|WP_181980972.1\|2127250_2127526_+\|hypothetical-protein	unknown	unknown	unknown
NC_016023.1\|WP_014097199.1\|2110995_2113359_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|224124
NC_016023.1\|WP_014097196.1\|2107338_2109363_+\|hypothetical-protein	cas8b1	mkCas0074_cas8b1_CAS-I-B	unknown
NC_016023.1\|WP_014097209.1\|2127646_2128066_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NC_016023.1\|WP_014097202.1\|2114199_2115558_+\|IS1182-like-element-ISBco4-family-transposase	unknown	unknown	gnl\|CDD\|376573
NC_016023.1\|WP_014097215.1\|2135994_2136417_-\|hypothetical-protein	unknown	unknown	unknown
NC_016023.1\|WP_014097203.1\|2115620_2116451_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|274695
NC_016023.1\|WP_179234616.1\|2124789_2125903_+\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|222853
NC_016023.1\|WP_014097213.1\|2134136_2135051_+\|DUF1002-domain-containing-protein	unknown	unknown	gnl\|CDD\|377628
NC_016023.1\|WP_014097204.1\|2116460_2116724_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NC_016023.1\|WP_014097212.1\|2132949_2133801_-\|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224651
NC_016023.1\|WP_014097214.1\|2135073_2135979_-\|hypothetical-protein	unknown	unknown	unknown
NC_016023.1\|WP_013860389.1\|2130120_2131422_+\|cation:dicarboxylase-symporter-family-transporter	unknown	unknown	gnl\|CDD\|183075

Protein	Function_ID	Function_description	E-value
NC_016023.1\|WP_013860391.1\|2128919_2129540_-\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	1.3128e-70
NC_016023.1\|WP_014097197.1\|2109349_2110306_+\|type-I-CRISPR-associated-protein-Cas7	gnl\|CDD\|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	4.05555e-74
NC_016023.1\|WP_014097205.1\|2122074_2123538_-\|transposase	gnl\|CDD\|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	5.90997e-05
NC_016023.1\|WP_014097195.1\|2106531_2107287_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|187889	cd09759, Cas6_I-A, CRISPR/Cas system-associated RAMP superfamily protein Cas6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas6 is an endoribonuclease that generates crRNAs, predicted subunit of Cascade complex; RAMP superfamily protein; Possesses double RRM/ferredoxin fold.	1.4264e-36
NC_016023.1\|WP_014097200.1\|2113371_2113881_+\|CRISPR-associated-protein-Cas4	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	1.90267e-68
NC_016023.1\|WP_014097198.1\|2110318_2111008_+\|CRISPR-associated-protein-Cas5	gnl\|CDD\|131641	TIGR02592, hypothetical_protein_CTC_01466, CRISPR-associated protein Cas5, subtype I-B/HMARI. This is a CRISPR-associated protein unique to the hmari subtype of cas genes and CRISPR repeat, which is the only subtype present in Haloarcula marismortui ATCC 43049. The hmari type, though uncommon, is also found in the Aquificae, Thermotogae, Firmicutes, and Dictyoglomi.	2.70428e-21
NC_016023.1\|WP_014097211.1\|2131648_2132794_+\|metallophosphoesterase	gnl\|CDD\|236506	PRK09420, cpdB, bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase.	5.49678e-154
NC_016023.1\|WP_014097212.1\|2132949_2133801_-\|MurR/RpiR-family-transcriptional-regulator	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	3.71174e-75
NC_016023.1\|WP_014097199.1\|2110995_2113359_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	1.99084e-37
NC_016023.1\|WP_014097209.1\|2127646_2128066_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	8.63089e-16
NC_016023.1\|WP_014097202.1\|2114199_2115558_+\|IS1182-like-element-ISBco4-family-transposase	gnl\|CDD\|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	2.73912e-15
NC_016023.1\|WP_014097203.1\|2115620_2116451_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274695	TIGR03641, cas1_HMARI, CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes Cas1 subgroup that includes Cas1 proteins of the related HMARI and TNEAP subtypes of CRISPR/Cas system.	2.08322e-132
NC_016023.1\|WP_179234616.1\|2124789_2125903_+\|IS3-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	3.74282e-41
NC_016023.1\|WP_014097213.1\|2134136_2135051_+\|DUF1002-domain-containing-protein	gnl\|CDD\|377628	pfam06207, DUF1002, Protein of unknown function (DUF1002). This protein family has no known function. Its members are about 300 amino acids in length. It has so far been detected in Firmicute bacteria and some archaebacteria.	7.04591e-83
NC_016023.1\|WP_014097204.1\|2116460_2116724_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	1.23108e-30
NC_016023.1\|WP_013860389.1\|2130120_2131422_+\|cation:dicarboxylase-symporter-family-transporter	gnl\|CDD\|183075	PRK11283, gltP, glutamate/aspartate:proton symporter; Provisional.	0

>NC_016023.1|WP_014097205.1|2122074_2123538_-|transposase
MTISILTQTRDFSIQQNLIPHNWQDYADIPFVIPAMCFPWEIFKPIEREYYTLLYLHLKNERAHDPSNEIQPALFSITEEEDKSASSLFHLPSTGRKPHPFMPFFRAFELASLQYIEVMVESVYLQVKSNPLFATMCGFTEKIPSYRSFARFDQIMTTNGLWEKARLLVVEYNKGEGVVETNEEAAAVDTSHIEAEATLNKTRKTCSCEGDCDCPKVLTDDNVGVMRKSNAVSYIAHKLSMVCGVRSGLPLTREVFKGNTPDGKTLEPTLETFKAEHPEMAEQLSFILADGIYQTPENQKVTKDVLQAKLVAPINPRNRKDKPTTARGIEKINRYGTPICISGHKMELRGSDREKGQYIYTCPVFHPNAKQEGLTCPLANHAECCNGAAQGRVFRMDFDQTPQVDVELPQHGRTFEVLYSARTIIERIFGILKDGYSLRRVHKRGKQAVEAHVDRCMISMHIMANMAYHQTGKANCGWTRNRLQRAN
>NC_016023.1|WP_014097204.1|2116460_2116724_+|CRISPR-associated-endonuclease-Cas2
MFIIVVYDFGVKRVAKALKTTRKYLNWVQNSVFEGEISNANYVKLKKELQALMNPEEDSVIFYTFRTKRYSKREEFGLKKGGDENII
>NC_016023.1|WP_014097203.1|2115620_2116451_+|type-I-B-CRISPR-associated-endonuclease-Cas1
MKLIHYFNHYGYYVGTFYPREHQNAGHIILKQAEHYLDNGKRLLLAKTFISGSIAQMGQVLKYYRTRVAKGKEEIENLLEQFNGNIKELEKGNTVEELMAVEGHSREEYYKMFDFITSNPDFVFEKRSRRPPLNRLNALISFGNSICYTTVLSEIYKTYLDPRIGYLHTTNFRRFSLNLDVAEIFKPIMVDRLIFTMINKKMLTKKDFDKHTEGITLSEAGRRKFVAELDKRMKTTVNHRHLGRTVSYRRLIRLELYKIQKHVMEEGNYVPYHSLW
>NC_016023.1|WP_014097202.1|2114199_2115558_+|IS1182-like-element-ISBco4-family-transposase
MTIIRQISFFGIQELYEMEPTHRYDAIISAINLDKICHAISKKSNLGAPEALNYAAMVISVFIRIVERIPTIKDLVKRLNEDIAFKLNCGFLVSDHIPSEASYSRLITKLEETNILEVSLKEVITQAISEGFIMDDTVAIDATHFEARDQAPPKKEKPDKEPKKRGRKPKEEREKWLAEQAEKEANLPIYEKKIEAQLDAPLDELRSQVPIDPKWGIKKNSEGKNVFWFGYKGHLAVGASSQYILQTLFSSGNLNDGKAAIPLLKGIQQRLNLPALHYTTMDAGYDYEPIYQQVYRMGCQSVIAYNKRNEPELEGFDKHFALTCFREYSYRYDSYDAKYETLKYTRPKECADCPLANEGICQKVYKVKITTDLRKYTAPARGSKAWKNIFKRRTAVERVNAYLKEFFQLNNVRYRTGKRAKVHFDLVTLIYNASKLAADRINAMIKQTQQAA
>NC_016023.1|WP_014097200.1|2113371_2113881_+|CRISPR-associated-protein-Cas4
MGYEMPVTGTDIWYYFICKRESWLMSHKITPDEEDENIEIGRFIHEYRYKREKQETAIDTIKLDRIKKVNGKLVVQEIKKSSRFETSARYQLLYYLDTLKQMGIEATGELLFPEERKKEMVEWTPEEKSVLDQAVEEIRKIAKMPVPPKPNKIKFCGKCAYKEFCWAGE
>NC_016023.1|WP_014097199.1|2110995_2113359_+|CRISPR-associated-helicase/endonuclease-Cas3
MPVLVPFDKCIARPDEEGKKHLLKNHLLRVKEFAENWISDTGEPVKELIGLAAICHDIAKSHADWQRYILDPEIKKGPTHAPQGAFLFSFLGYHWLEITRQWEAYRVVWLWLVRDIADHHGKLKKLQDDNWLQRYDWEKMDFEGISSFLKDHYPEFSGLELTIDSMDDWLDVADEQIEEAMDDLDTGFGQKKDFDLMVHLQAWRALTTALIAGDRFDVKDTGTSWFDEKTIEKCEAALGRYCTAKAGSPLAQARSQAQKNIIKQMAEQPASWFYTLELPTGYGKTITALKLSLWLGKQRHYRKIVYVAPYLSILEQTSRVIGEAMDIGALEHHSLAILDQSNKSGTQGEQRAPNDELAMESWAHSVICTSFQQWSKAIFPGRAQDVLRRSFLKDSIIIIDEPQIFNPDGWNLFLTGLEAIAKQQHLCVLFLSATMPPFEYGLSRKPIRLAASGSQVERYQVRLEEKMDEEKMAAFLNDREDIKQAAILNTIEDAYRVYKQINGEEDVRLLHGLMVPVHKKLEIAKIQDHLEKEKEKRLIVIATQIIEAGVDVSFHHVIRALPILPSIVQAAGRVNRHFETDNGILTIAPFFRNGEKNTRNSIYARPLQRITDRLLFEKDIWLESEMEPLVRRYYEEMFRENTYETAKQAIREAYEGDWPQLSKYEPFGQDYLKLPLFVPWEVPEEDEKWLPEQFLWLRKKFGVTDAASIYERYSNVNFMNGLSFEERKQFMILFHHFVLNVPVKTALRFVSQEEYLQSNRVPLLYSEGAYDQNLGLVGHFDELDNFI
>NC_016023.1|WP_014097198.1|2110318_2111008_+|CRISPR-associated-protein-Cas5
MEAVVFDLKSDLAHFRRPDTTSTQLTYPFISPTAVKGIAGAILGIEDFTTRDKIGIQLLHPVKTVSQQMSMLGKDSGSTFNRPTTVELVVKPFYRIYYAGDEYVRDLYRFLSKGRAVYPTYLGSAYALTKPVLQAYYEQVEPLREWSEPLRTRCVVPTRLVKEMKFEPERYYSRAGGFMLVYKGSREFEKSIDFVYERNGDAITFLPDKRQISDELQIVQIGDETVCLF
>NC_016023.1|WP_014097197.1|2109349_2110306_+|type-I-CRISPR-associated-protein-Cas7
MPVRNGELLFIKSVKDGIPNRDPLNDSDARRIFPEEDGRISLSDVSIKRDVRDFVIDYQADGGSQQKNYIFVQEKFNEKGKLLGRGSLAEGIAKAVGKEKESKTDMKSVLLEHSFDVRTFGVVYSVKPKFNLTGPVQFGWAHSMHPVDSQYVQGTVVMPSTDSKGDEEGKTQGTIWTSYTVPFAVFAMPGIINAKNAEHSQMTEEDQELLLRALWQGTQHRQARGRGQQQPLLLAHIEYKDPFYRIGYLEDLVSLKPGEETWRNEGRRPSSLKDITLDLTELLKTIEEQQDKIARCRIWLHPSAQIEGEISKYQSPLW
>NC_016023.1|WP_014097196.1|2107338_2109363_+|hypothetical-protein
MLAESIIRIGRPIANSPDLPVKERIRWLTDVESENCKNFFQNVLIVELGNVGDALSYVTVGKAGEGKKSFIVDANQSTSFPILYPNGGNPLKAQGVYPVPCYLMYEPHMKAMAEKEQFYQALLPRLKKTVGYMKLGIEEIEAVAGRVSEILEAHHTDFLTEEKQLGILMIYDERLPVYLKLSGKSDNPDELWIRESRLEPGKQLYLNGREALQGIIDAKFDEASTLGKEHNAVSTFTNQKTEEVVSVYNKSWLWLSPTWEMPKSIYWGKDEWTKGIKVDKKSYESYLYGTQFLKKIQVPLSNTVLKEMFSPISSVEAKKHMRAGSFEQIFGIPMVLPLLDEDSEQYYQKFLRILRTNQDLKEEDLHLELLAGMKQSIVPRSSDQYRLTILYYSGDLSRGSMHIRAVIEDVIPSVAYEVQNIIKQLRRRHLGQIQAVFELEQRPFFRVESLPSILANAYGPGYVWSTMQAVLHREPLTLERAVSATAKRLNELANKESYWEMKQELVFFYSFVFFLNRYNEKILAKGKDVKELADWKAMIEKYHAGSVELEDLHNAETLGFVSGLLLKQFSNSYYKKTGKDYVKHRVMKFGSKLTPEMIWKYGTLRCEELAQQWDLNISKNFHAVLAQVLLGFIEADKENLLISQKDAFMTAFWSGYLSYKSNKKQEGEEINAGA
>NC_016023.1|WP_014097195.1|2106531_2107287_+|CRISPR-associated-endoribonuclease-Cas6
MKLIVTFSANDNALKLPLNYQQMLQGFIYRNLLDPDFSRFLHNHGFLNGKRIFKLFVFSQLFGKYSLLKETKEIVFKGPVTWHVGSVVPEFIKGFGRSLLTSGHLELNGQEMKVEEVTYRQDTPESEKCRIRMLSPITVYSTYQNQNGKKITQYFDPKDPAFTYLVEENIKKKYAAFYQKDTQDLFFKIQPVRVTEKDKRITRYKGFIINGWGGIYVIEGSPNLLSFAESTGLGSKNSQGFGMFEVIHQQL
>NC_016023.1|WP_179234616.1|2124789_2125903_+|IS3-family-transposase
MRKSYTPEFKTQVVLEVLKEEKTMNEIASAHGIHVNQIRQWRNAFLEQMPKVFEKGNKKVEKMKAEYEQTIESLYAEVGRLTTQLSWLKKKNLELRSRAERVEMVDWDDEAKLPISIQADLLSLNRSSLYYKPVGPSPEELFIKHRIDEIYTKHPYYGSRRIAALLNAEGLVINRKAVQRHMREMGIAGITPGPNLSKRSLEHRIYPYLLRNLKITHPNHVWGIDITYIRLQKSWMYLVALIDWYSRYVVSWEIDQTLEIDFVLEAVKRAFLVARPEILNSDQGSHFTSPKYTDLVLENTIKISMDGKKRALDNIITERLWRTIKYEEVYLKEYNSPREARKEIGNFIQFYNHERLHQALGYKTPASVYGL
>NC_016023.1|WP_181980972.1|2127250_2127526_+|hypothetical-protein
MVYRIVLFLLPEVLPVIIPVPTVPCSLACSCLARKKRAQVPPAGIIKQKQAALPKKDFKVFPIEGLLSEPDKALSLVRSAAKLVDAAFFFL
>NC_016023.1|WP_014097209.1|2127646_2128066_-|helix-turn-helix-transcriptional-regulator
MADHGNENMDNVKAIFAARLKKVRAAQGYSQPELAKRVGVSDRNISNYETGYSFPSIKVLYRISQVLKVSIDYLLGLTNHVGLKTNEAVSNPEKKLLETLSHEPDLYQMMLKDPEKMANRIYQTWNLIRELDDEDDKNT
>NC_016023.1|WP_013860391.1|2128919_2129540_-|histidine-phosphatase-family-protein
MTLFYFVRHGQTEWNADRNRYCGRSDIGLSETGVRQAKLAAGFLKDIPFDAVYASTLGRAVRTAEILVKGRNLEIHQDPRLVETDFGAWEGERQEDFSVNYADNWEAWLQDPGATHAGYTGETAVQVYNRVRACINELVEKHPEETVLVVAHSMAIRFFVAGTLEVPFKNYRMIPQDNTGITIYKEAPENAGFLAINLNTHLYAIK
>NC_016023.1|WP_013860389.1|2130120_2131422_+|cation:dicarboxylase-symporter-family-transporter
MKRVSLAWQIFIGLILGIAIGGIFHGNDTVAHILQPFGDFFLRLIKMIVIPIVVSSLIVGVAGAGDMKQVGKLGLKALIYFEIVTTIAIVVGLLAGNLFHPGTGVDMGSLAKTSISSYVETTKETQHNGIVDTILNIVPTNLFESLSQGNMLPIIFFSVMFGIGVAAIGEKGKPVLRFFQGVSEAMFYVTNLVMKVAPIGVFGLIGVTVAQFGLKSLIPLSKLVFTVYGTIIFFVVVVLGLIGWLFRVNIFKLFKILKDELILAYSTASSEAVLPRLMEKMEKFGCPKSITTLVIPTGYSFNLDGSTLYQSLAALFIAQMYGIHMSIGAQISLVLVLMVTSKGIAGVPGVSFVVLLATLGTVGIPIEGLAFIAGIDRILDMARTVCNVVGNTLATIIVSKWEGKYDKEKGEAYLAEISGGGHDSKDHKYVTES
>NC_016023.1|WP_014097211.1|2131648_2132794_+|metallophosphoesterase
MGKKMLLWAAVLSLALFPRTEHADAAFWFQPKRATVDLRLLETSDLHGYMLNYDYAARTEAETYGLALTASLIAAERKAAKNTMLFDDGDLLEGSEMAAYAARRPLKKGEIHPFIRVMNHLNYDAATVGNHDFHYGLDFLKQTISGAKFPFVNANIYYNFEKNDTDDQNFFKPYVILNKKVEDRHGHSHHLKIGVIGFVTPSVIEWEKPSLGGKVKAKDILHTAAWFVPRMKAEGADLIIALAHCGVDPAAKQPFYTGDAVYLLSEVKGIDAILFGHQHRVFPSEFFAGVPGVDIRKGTINGVPAVMPGKWGSHLGVISLTLEKKGEKWEMTEAQSEAKPVYATHNQQAKSIVRPDPDIVRMTAELQKNVLGSKFTLYSRN
>NC_016023.1|WP_014097212.1|2132949_2133801_-|MurR/RpiR-family-transcriptional-regulator
MGTQLQSFPCLHRIQTMYSEFSAKERKIADYILENPQRLVHSTINQVADQLLVADATVFRFCKRIGFSGFQALKIALAAEAARPGKNMDEAVKDTDNEKAVAIKVFESNIETLQDTIHTLNQKHLHEAVEWICRAKHIVFYGCGSASVIALDALEKFLQTDLAVTAYTDPHLQLLSAARCTKEDVAVFISHAGADKEMLKLLQAVQKTGAKTIAITQFAKSPLSQKADVPLFTVSQEADFRFSSFSARIVQLSLIDTLYVNVMLRYKDTNEEILQKGKETYTV
>NC_016023.1|WP_014097213.1|2134136_2135051_+|DUF1002-domain-containing-protein
MLKRLGLIWFIAMIALGFSMNGVAKASGDNSTVIDEKYGKPIVVTGAALSASQKAEVEKELGVDDANNVEEITVTGDDLVHYIPDGNRNSNMYSSAKITRTDSGGVQVNIVTPENITEVTADMYKNALLTAGIKNAEVEVASPLKVTGHSALVGIYKAYDDSSKSGDKLDSDRTEVASQELSVATDLAKKEGLSNDKVTQLLTEIKQEIADQHPATKEDIEKIVDDKLKDLNINLSDSDRQLLYDLFDQMRKLNINFDSVKSELSSLSDKLSDKINKAAGDKGFWQSVKDFFQNIFDAIRGLFQ
>NC_016023.1|WP_014097214.1|2135073_2135979_-|hypothetical-protein
MVRQVKKTKSFLLTAVFIAFNFCFFTNISVAESPATDGFIIEADRVEGVMLPPGITAGDTATKQNQVMLRLQYADVTIYGLKITKVLQTPGGPVTIHMNAPGPIQLKNMKADATKVDFGSIYVPEKAGQIGMKNVRLVAHQQLADNADLPGLDLSMETGAANFDTSGSDEETLRKQADQLTQLLKGGTPEQNKEEKNGKSDTADKAKADTQDKAKTETQDTKKQHDAKTDGKVTDQNKNKKSENADDTKTKNAEETKSDNTGTKPASGQGTEQNGTPAKTAPGQSSTDKNVQQKEGSSAGN
>NC_016023.1|WP_014097215.1|2135994_2136417_-|hypothetical-protein
MGKFHMFRMKFRNWRRSRPFWGATFTLLSGMIILYVPVQLLEIAAAPGSMVSIGLIFGGLIFLIGGMGYFFPKFNMVFGILAIFLSVLSIMGAMGGFFIGTLLGIIGGSLSVSWRVIRQEEVLASVGPMEEIAAGSAEER

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Crispr_ID: NC_016023_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016023_13

2126172-2127007

TypeI-B

Consensus_repeat	Method
GTTTCAATTCCTCATAGGTAAAATACAAAC	PILER-CR
GTTTGTATTTTACCTATGAGGAATTGAAAC	CRISPRCasFinder
GTTTGTATTTTACCTATGAGGAATTGAAAC	CRT

12 spacers

cas2,cas1,cas4,cas3,cas5,cas7b,cas8b1

The CRISPR arrays of NC_016023_13

>merge|NC_016023|13|2126172-2127007|PILER-CR,CRISPRCasFinder,CRT
GTTTGTATTTTACCTATGAGGAATTGAAACGCATCTGCATCCGTTTTTGTTATCCTGGCTGCAATTGTTTGTATTTTACCTATGAGGAATTGAAACTATTCCAACCCGGTTAATCTATTCAGGCATGTATCCGTTTGTATTTTACCTATGAGGAATTGAAACTCGATAATGTCAAGGCTGGTATAGAAGAATTGCAAAAGTTTGTATTTTACCAATGAGGAATTGAAACAAGTATGCCGGAGATGTGGCGTGAAAAATCCATTTCGCGTTTGTATTTTACCTATGAGGAATTGAAACAATAAAGTTGAAATTTTACTGATTCGGTCACTATATGTTTGTATTTTACCTATGAGGAATTGAAACCGCGTGTCGTCCGTATCGTCGGCGCATAAGCGGTCCAAAGTTTGTATTTTACCTATGAGGAATTGAAACGTTTCATATCCCATCCACCGCCCGTTTGCATATTAGTTTGTATTTTACCTATGAGGAATTGAAACTACGTTACATCCGGCAGCTCCAAATAATCCTCTGCCTTCGTTTGTATTTTACCTATGAGGAATTGAAACAGATATTTCTCAGCCGCGCTGCTTCCGTCCAGCTCCGGTTTGTATTTTACCTATGAGGAATTGAAACCGCCGTATTCTTCAGCTATTACTTTCAGCGTTTTCTTGTTTGTATTTTACCTATAAGGAATTGAAACAGTCGGCATGACTGAAATAATTTAGGCAGATTTTCATTGTTTGTACTTTACCTATAAGGAATTGAAACCATTCCGGGCAAAGTTCGGAGAAATACCGGTCTGCCTTGTTTGTACTTTACCTATGAGGAATTAAAAC

>NC_016023|13|5|2126172-2126939|PILER-CR
GTTTGTATTTTACCTATGAGGAATTGAAAC	GCATCTGCATCCGTTTTTGTTATCCTGGCTGCAATT
GTTTGTATTTTACCTATGAGGAATTGAAAC	TATTCCAACCCGGTTAATCTATTCAGGCATGTATCC
GTTTGTATTTTACCTATGAGGAATTGAAAC	TCGATAATGTCAAGGCTGGTATAGAAGAATTGCAAAA
GTTTGTATTTTACCAATGAGGAATTGAAAC	AAGTATGCCGGAGATGTGGCGTGAAAAATCCATTTCGC
GTTTGTATTTTACCTATGAGGAATTGAAAC	AATAAAGTTGAAATTTTACTGATTCGGTCACTATAT
GTTTGTATTTTACCTATGAGGAATTGAAAC	CGCGTGTCGTCCGTATCGTCGGCGCATAAGCGGTCCAAA
GTTTGTATTTTACCTATGAGGAATTGAAAC	GTTTCATATCCCATCCACCGCCCGTTTGCATATTA
GTTTGTATTTTACCTATGAGGAATTGAAAC	TACGTTACATCCGGCAGCTCCAAATAATCCTCTGCCTTC
GTTTGTATTTTACCTATGAGGAATTGAAAC	AGATATTTCTCAGCCGCGCTGCTTCCGTCCAGCTCCG
GTTTGTATTTTACCTATGAGGAATTGAAAC	CGCCGTATTCTTCAGCTATTACTTTCAGCGTTTTCTT
GTTTGTATTTTACCTATAAGGAATTGAAAC	AGTCGGCATGACTGAAATAATTTAGGCAGATTTTCATT
GTTTGTACTTTACCTATAAGGAATTGAAAC

>NC_016023|13|12|2126172-2127007|CRISPRCasFinder
GTTTGTATTTTACCTATGAGGAATTGAAAC	GCATCTGCATCCGTTTTTGTTATCCTGGCTGCAATT
GTTTGTATTTTACCTATGAGGAATTGAAAC	TATTCCAACCCGGTTAATCTATTCAGGCATGTATCC
GTTTGTATTTTACCTATGAGGAATTGAAAC	TCGATAATGTCAAGGCTGGTATAGAAGAATTGCAAAA
GTTTGTATTTTACCAATGAGGAATTGAAAC	AAGTATGCCGGAGATGTGGCGTGAAAAATCCATTTCGC
GTTTGTATTTTACCTATGAGGAATTGAAAC	AATAAAGTTGAAATTTTACTGATTCGGTCACTATAT
GTTTGTATTTTACCTATGAGGAATTGAAAC	CGCGTGTCGTCCGTATCGTCGGCGCATAAGCGGTCCAAA
GTTTGTATTTTACCTATGAGGAATTGAAAC	GTTTCATATCCCATCCACCGCCCGTTTGCATATTA
GTTTGTATTTTACCTATGAGGAATTGAAAC	TACGTTACATCCGGCAGCTCCAAATAATCCTCTGCCTTC
GTTTGTATTTTACCTATGAGGAATTGAAAC	AGATATTTCTCAGCCGCGCTGCTTCCGTCCAGCTCCG
GTTTGTATTTTACCTATGAGGAATTGAAAC	CGCCGTATTCTTCAGCTATTACTTTCAGCGTTTTCTT
GTTTGTATTTTACCTATAAGGAATTGAAAC	AGTCGGCATGACTGAAATAATTTAGGCAGATTTTCATT
GTTTGTACTTTACCTATAAGGAATTGAAAC	CATTCCGGGCAAAGTTCGGAGAAATACCGGTCTGCCTT
GTTTGTACTTTACCTATGAGGAATTAAAAC

>NC_016023|13|5|2126172-2127007|CRT
GTTTGTATTTTACCTATGAGGAATTGAAAC	GCATCTGCATCCGTTTTTGTTATCCTGGCTGCAATT
GTTTGTATTTTACCTATGAGGAATTGAAAC	TATTCCAACCCGGTTAATCTATTCAGGCATGTATCC
GTTTGTATTTTACCTATGAGGAATTGAAAC	TCGATAATGTCAAGGCTGGTATAGAAGAATTGCAAAA
GTTTGTATTTTACCAATGAGGAATTGAAAC	AAGTATGCCGGAGATGTGGCGTGAAAAATCCATTTCGC
GTTTGTATTTTACCTATGAGGAATTGAAAC	AATAAAGTTGAAATTTTACTGATTCGGTCACTATAT
GTTTGTATTTTACCTATGAGGAATTGAAAC	CGCGTGTCGTCCGTATCGTCGGCGCATAAGCGGTCCAAA
GTTTGTATTTTACCTATGAGGAATTGAAAC	GTTTCATATCCCATCCACCGCCCGTTTGCATATTA
GTTTGTATTTTACCTATGAGGAATTGAAAC	TACGTTACATCCGGCAGCTCCAAATAATCCTCTGCCTTC
GTTTGTATTTTACCTATGAGGAATTGAAAC	AGATATTTCTCAGCCGCGCTGCTTCCGTCCAGCTCCG
GTTTGTATTTTACCTATGAGGAATTGAAAC	CGCCGTATTCTTCAGCTATTACTTTCAGCGTTTTCTT
GTTTGTATTTTACCTATAAGGAATTGAAAC	AGTCGGCATGACTGAAATAATTTAGGCAGATTTTCATT
GTTTGTACTTTACCTATAAGGAATTGAAAC	CATTCCGGGCAAAGTTCGGAGAAATACCGGTCTGCCTT
GTTTGTACTTTACCTATGAGGAATTAAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_016023.1\|WP_013860391.1\|2128919_2129540_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
NC_016023.1\|WP_014097197.1\|2109349_2110306_+\|type-I-CRISPR-associated-protein-Cas7	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	gnl\|CDD\|377458
NC_016023.1\|WP_014097216.1\|2136441_2137050_-\|hypothetical-protein	unknown	unknown	unknown
NC_016023.1\|WP_014097211.1\|2131648_2132794_+\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|236506
NC_016023.1\|WP_014097205.1\|2122074_2123538_-\|transposase	unknown	unknown	gnl\|CDD\|376573
NC_016023.1\|WP_181980972.1\|2127250_2127526_+\|hypothetical-protein	unknown	unknown	unknown
NC_016023.1\|WP_014097198.1\|2110318_2111008_+\|CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	gnl\|CDD\|131641
NC_016023.1\|WP_014097200.1\|2113371_2113881_+\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
NC_016023.1\|WP_014097199.1\|2110995_2113359_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|224124
NC_016023.1\|WP_014097196.1\|2107338_2109363_+\|hypothetical-protein	cas8b1	mkCas0074_cas8b1_CAS-I-B	unknown
NC_016023.1\|WP_014097209.1\|2127646_2128066_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NC_016023.1\|WP_014097202.1\|2114199_2115558_+\|IS1182-like-element-ISBco4-family-transposase	unknown	unknown	gnl\|CDD\|376573
NC_016023.1\|WP_014097215.1\|2135994_2136417_-\|hypothetical-protein	unknown	unknown	unknown
NC_016023.1\|WP_014097203.1\|2115620_2116451_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|274695
NC_016023.1\|WP_179234616.1\|2124789_2125903_+\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|222853
NC_016023.1\|WP_014097213.1\|2134136_2135051_+\|DUF1002-domain-containing-protein	unknown	unknown	gnl\|CDD\|377628
NC_016023.1\|WP_014097204.1\|2116460_2116724_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NC_016023.1\|WP_014097212.1\|2132949_2133801_-\|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224651
NC_016023.1\|WP_014097214.1\|2135073_2135979_-\|hypothetical-protein	unknown	unknown	unknown
NC_016023.1\|WP_013860389.1\|2130120_2131422_+\|cation:dicarboxylase-symporter-family-transporter	unknown	unknown	gnl\|CDD\|183075

Protein	Function_ID	Function_description	E-value
NC_016023.1\|WP_013860391.1\|2128919_2129540_-\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	1.3128e-70
NC_016023.1\|WP_014097197.1\|2109349_2110306_+\|type-I-CRISPR-associated-protein-Cas7	gnl\|CDD\|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	4.05555e-74
NC_016023.1\|WP_014097211.1\|2131648_2132794_+\|metallophosphoesterase	gnl\|CDD\|236506	PRK09420, cpdB, bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase.	5.49678e-154
NC_016023.1\|WP_014097205.1\|2122074_2123538_-\|transposase	gnl\|CDD\|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	5.90997e-05
NC_016023.1\|WP_014097200.1\|2113371_2113881_+\|CRISPR-associated-protein-Cas4	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	1.90267e-68
NC_016023.1\|WP_014097198.1\|2110318_2111008_+\|CRISPR-associated-protein-Cas5	gnl\|CDD\|131641	TIGR02592, hypothetical_protein_CTC_01466, CRISPR-associated protein Cas5, subtype I-B/HMARI. This is a CRISPR-associated protein unique to the hmari subtype of cas genes and CRISPR repeat, which is the only subtype present in Haloarcula marismortui ATCC 43049. The hmari type, though uncommon, is also found in the Aquificae, Thermotogae, Firmicutes, and Dictyoglomi.	2.70428e-21
NC_016023.1\|WP_014097212.1\|2132949_2133801_-\|MurR/RpiR-family-transcriptional-regulator	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	3.71174e-75
NC_016023.1\|WP_014097199.1\|2110995_2113359_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	1.99084e-37
NC_016023.1\|WP_014097209.1\|2127646_2128066_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	8.63089e-16
NC_016023.1\|WP_014097202.1\|2114199_2115558_+\|IS1182-like-element-ISBco4-family-transposase	gnl\|CDD\|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	2.73912e-15
NC_016023.1\|WP_014097203.1\|2115620_2116451_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274695	TIGR03641, cas1_HMARI, CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes Cas1 subgroup that includes Cas1 proteins of the related HMARI and TNEAP subtypes of CRISPR/Cas system.	2.08322e-132
NC_016023.1\|WP_179234616.1\|2124789_2125903_+\|IS3-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	3.74282e-41
NC_016023.1\|WP_014097213.1\|2134136_2135051_+\|DUF1002-domain-containing-protein	gnl\|CDD\|377628	pfam06207, DUF1002, Protein of unknown function (DUF1002). This protein family has no known function. Its members are about 300 amino acids in length. It has so far been detected in Firmicute bacteria and some archaebacteria.	7.04591e-83
NC_016023.1\|WP_014097204.1\|2116460_2116724_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	1.23108e-30
NC_016023.1\|WP_013860389.1\|2130120_2131422_+\|cation:dicarboxylase-symporter-family-transporter	gnl\|CDD\|183075	PRK11283, gltP, glutamate/aspartate:proton symporter; Provisional.	0

>NC_016023.1|WP_179234616.1|2124789_2125903_+|IS3-family-transposase
MRKSYTPEFKTQVVLEVLKEEKTMNEIASAHGIHVNQIRQWRNAFLEQMPKVFEKGNKKVEKMKAEYEQTIESLYAEVGRLTTQLSWLKKKNLELRSRAERVEMVDWDDEAKLPISIQADLLSLNRSSLYYKPVGPSPEELFIKHRIDEIYTKHPYYGSRRIAALLNAEGLVINRKAVQRHMREMGIAGITPGPNLSKRSLEHRIYPYLLRNLKITHPNHVWGIDITYIRLQKSWMYLVALIDWYSRYVVSWEIDQTLEIDFVLEAVKRAFLVARPEILNSDQGSHFTSPKYTDLVLENTIKISMDGKKRALDNIITERLWRTIKYEEVYLKEYNSPREARKEIGNFIQFYNHERLHQALGYKTPASVYGL
>NC_016023.1|WP_014097205.1|2122074_2123538_-|transposase
MTISILTQTRDFSIQQNLIPHNWQDYADIPFVIPAMCFPWEIFKPIEREYYTLLYLHLKNERAHDPSNEIQPALFSITEEEDKSASSLFHLPSTGRKPHPFMPFFRAFELASLQYIEVMVESVYLQVKSNPLFATMCGFTEKIPSYRSFARFDQIMTTNGLWEKARLLVVEYNKGEGVVETNEEAAAVDTSHIEAEATLNKTRKTCSCEGDCDCPKVLTDDNVGVMRKSNAVSYIAHKLSMVCGVRSGLPLTREVFKGNTPDGKTLEPTLETFKAEHPEMAEQLSFILADGIYQTPENQKVTKDVLQAKLVAPINPRNRKDKPTTARGIEKINRYGTPICISGHKMELRGSDREKGQYIYTCPVFHPNAKQEGLTCPLANHAECCNGAAQGRVFRMDFDQTPQVDVELPQHGRTFEVLYSARTIIERIFGILKDGYSLRRVHKRGKQAVEAHVDRCMISMHIMANMAYHQTGKANCGWTRNRLQRAN
>NC_016023.1|WP_014097204.1|2116460_2116724_+|CRISPR-associated-endonuclease-Cas2
MFIIVVYDFGVKRVAKALKTTRKYLNWVQNSVFEGEISNANYVKLKKELQALMNPEEDSVIFYTFRTKRYSKREEFGLKKGGDENII
>NC_016023.1|WP_014097203.1|2115620_2116451_+|type-I-B-CRISPR-associated-endonuclease-Cas1
MKLIHYFNHYGYYVGTFYPREHQNAGHIILKQAEHYLDNGKRLLLAKTFISGSIAQMGQVLKYYRTRVAKGKEEIENLLEQFNGNIKELEKGNTVEELMAVEGHSREEYYKMFDFITSNPDFVFEKRSRRPPLNRLNALISFGNSICYTTVLSEIYKTYLDPRIGYLHTTNFRRFSLNLDVAEIFKPIMVDRLIFTMINKKMLTKKDFDKHTEGITLSEAGRRKFVAELDKRMKTTVNHRHLGRTVSYRRLIRLELYKIQKHVMEEGNYVPYHSLW
>NC_016023.1|WP_014097202.1|2114199_2115558_+|IS1182-like-element-ISBco4-family-transposase
MTIIRQISFFGIQELYEMEPTHRYDAIISAINLDKICHAISKKSNLGAPEALNYAAMVISVFIRIVERIPTIKDLVKRLNEDIAFKLNCGFLVSDHIPSEASYSRLITKLEETNILEVSLKEVITQAISEGFIMDDTVAIDATHFEARDQAPPKKEKPDKEPKKRGRKPKEEREKWLAEQAEKEANLPIYEKKIEAQLDAPLDELRSQVPIDPKWGIKKNSEGKNVFWFGYKGHLAVGASSQYILQTLFSSGNLNDGKAAIPLLKGIQQRLNLPALHYTTMDAGYDYEPIYQQVYRMGCQSVIAYNKRNEPELEGFDKHFALTCFREYSYRYDSYDAKYETLKYTRPKECADCPLANEGICQKVYKVKITTDLRKYTAPARGSKAWKNIFKRRTAVERVNAYLKEFFQLNNVRYRTGKRAKVHFDLVTLIYNASKLAADRINAMIKQTQQAA
>NC_016023.1|WP_014097200.1|2113371_2113881_+|CRISPR-associated-protein-Cas4
MGYEMPVTGTDIWYYFICKRESWLMSHKITPDEEDENIEIGRFIHEYRYKREKQETAIDTIKLDRIKKVNGKLVVQEIKKSSRFETSARYQLLYYLDTLKQMGIEATGELLFPEERKKEMVEWTPEEKSVLDQAVEEIRKIAKMPVPPKPNKIKFCGKCAYKEFCWAGE
>NC_016023.1|WP_014097199.1|2110995_2113359_+|CRISPR-associated-helicase/endonuclease-Cas3
MPVLVPFDKCIARPDEEGKKHLLKNHLLRVKEFAENWISDTGEPVKELIGLAAICHDIAKSHADWQRYILDPEIKKGPTHAPQGAFLFSFLGYHWLEITRQWEAYRVVWLWLVRDIADHHGKLKKLQDDNWLQRYDWEKMDFEGISSFLKDHYPEFSGLELTIDSMDDWLDVADEQIEEAMDDLDTGFGQKKDFDLMVHLQAWRALTTALIAGDRFDVKDTGTSWFDEKTIEKCEAALGRYCTAKAGSPLAQARSQAQKNIIKQMAEQPASWFYTLELPTGYGKTITALKLSLWLGKQRHYRKIVYVAPYLSILEQTSRVIGEAMDIGALEHHSLAILDQSNKSGTQGEQRAPNDELAMESWAHSVICTSFQQWSKAIFPGRAQDVLRRSFLKDSIIIIDEPQIFNPDGWNLFLTGLEAIAKQQHLCVLFLSATMPPFEYGLSRKPIRLAASGSQVERYQVRLEEKMDEEKMAAFLNDREDIKQAAILNTIEDAYRVYKQINGEEDVRLLHGLMVPVHKKLEIAKIQDHLEKEKEKRLIVIATQIIEAGVDVSFHHVIRALPILPSIVQAAGRVNRHFETDNGILTIAPFFRNGEKNTRNSIYARPLQRITDRLLFEKDIWLESEMEPLVRRYYEEMFRENTYETAKQAIREAYEGDWPQLSKYEPFGQDYLKLPLFVPWEVPEEDEKWLPEQFLWLRKKFGVTDAASIYERYSNVNFMNGLSFEERKQFMILFHHFVLNVPVKTALRFVSQEEYLQSNRVPLLYSEGAYDQNLGLVGHFDELDNFI
>NC_016023.1|WP_014097198.1|2110318_2111008_+|CRISPR-associated-protein-Cas5
MEAVVFDLKSDLAHFRRPDTTSTQLTYPFISPTAVKGIAGAILGIEDFTTRDKIGIQLLHPVKTVSQQMSMLGKDSGSTFNRPTTVELVVKPFYRIYYAGDEYVRDLYRFLSKGRAVYPTYLGSAYALTKPVLQAYYEQVEPLREWSEPLRTRCVVPTRLVKEMKFEPERYYSRAGGFMLVYKGSREFEKSIDFVYERNGDAITFLPDKRQISDELQIVQIGDETVCLF
>NC_016023.1|WP_014097197.1|2109349_2110306_+|type-I-CRISPR-associated-protein-Cas7
MPVRNGELLFIKSVKDGIPNRDPLNDSDARRIFPEEDGRISLSDVSIKRDVRDFVIDYQADGGSQQKNYIFVQEKFNEKGKLLGRGSLAEGIAKAVGKEKESKTDMKSVLLEHSFDVRTFGVVYSVKPKFNLTGPVQFGWAHSMHPVDSQYVQGTVVMPSTDSKGDEEGKTQGTIWTSYTVPFAVFAMPGIINAKNAEHSQMTEEDQELLLRALWQGTQHRQARGRGQQQPLLLAHIEYKDPFYRIGYLEDLVSLKPGEETWRNEGRRPSSLKDITLDLTELLKTIEEQQDKIARCRIWLHPSAQIEGEISKYQSPLW
>NC_016023.1|WP_014097196.1|2107338_2109363_+|hypothetical-protein
MLAESIIRIGRPIANSPDLPVKERIRWLTDVESENCKNFFQNVLIVELGNVGDALSYVTVGKAGEGKKSFIVDANQSTSFPILYPNGGNPLKAQGVYPVPCYLMYEPHMKAMAEKEQFYQALLPRLKKTVGYMKLGIEEIEAVAGRVSEILEAHHTDFLTEEKQLGILMIYDERLPVYLKLSGKSDNPDELWIRESRLEPGKQLYLNGREALQGIIDAKFDEASTLGKEHNAVSTFTNQKTEEVVSVYNKSWLWLSPTWEMPKSIYWGKDEWTKGIKVDKKSYESYLYGTQFLKKIQVPLSNTVLKEMFSPISSVEAKKHMRAGSFEQIFGIPMVLPLLDEDSEQYYQKFLRILRTNQDLKEEDLHLELLAGMKQSIVPRSSDQYRLTILYYSGDLSRGSMHIRAVIEDVIPSVAYEVQNIIKQLRRRHLGQIQAVFELEQRPFFRVESLPSILANAYGPGYVWSTMQAVLHREPLTLERAVSATAKRLNELANKESYWEMKQELVFFYSFVFFLNRYNEKILAKGKDVKELADWKAMIEKYHAGSVELEDLHNAETLGFVSGLLLKQFSNSYYKKTGKDYVKHRVMKFGSKLTPEMIWKYGTLRCEELAQQWDLNISKNFHAVLAQVLLGFIEADKENLLISQKDAFMTAFWSGYLSYKSNKKQEGEEINAGA
>NC_016023.1|WP_181980972.1|2127250_2127526_+|hypothetical-protein
MVYRIVLFLLPEVLPVIIPVPTVPCSLACSCLARKKRAQVPPAGIIKQKQAALPKKDFKVFPIEGLLSEPDKALSLVRSAAKLVDAAFFFL
>NC_016023.1|WP_014097209.1|2127646_2128066_-|helix-turn-helix-transcriptional-regulator
MADHGNENMDNVKAIFAARLKKVRAAQGYSQPELAKRVGVSDRNISNYETGYSFPSIKVLYRISQVLKVSIDYLLGLTNHVGLKTNEAVSNPEKKLLETLSHEPDLYQMMLKDPEKMANRIYQTWNLIRELDDEDDKNT
>NC_016023.1|WP_013860391.1|2128919_2129540_-|histidine-phosphatase-family-protein
MTLFYFVRHGQTEWNADRNRYCGRSDIGLSETGVRQAKLAAGFLKDIPFDAVYASTLGRAVRTAEILVKGRNLEIHQDPRLVETDFGAWEGERQEDFSVNYADNWEAWLQDPGATHAGYTGETAVQVYNRVRACINELVEKHPEETVLVVAHSMAIRFFVAGTLEVPFKNYRMIPQDNTGITIYKEAPENAGFLAINLNTHLYAIK
>NC_016023.1|WP_013860389.1|2130120_2131422_+|cation:dicarboxylase-symporter-family-transporter
MKRVSLAWQIFIGLILGIAIGGIFHGNDTVAHILQPFGDFFLRLIKMIVIPIVVSSLIVGVAGAGDMKQVGKLGLKALIYFEIVTTIAIVVGLLAGNLFHPGTGVDMGSLAKTSISSYVETTKETQHNGIVDTILNIVPTNLFESLSQGNMLPIIFFSVMFGIGVAAIGEKGKPVLRFFQGVSEAMFYVTNLVMKVAPIGVFGLIGVTVAQFGLKSLIPLSKLVFTVYGTIIFFVVVVLGLIGWLFRVNIFKLFKILKDELILAYSTASSEAVLPRLMEKMEKFGCPKSITTLVIPTGYSFNLDGSTLYQSLAALFIAQMYGIHMSIGAQISLVLVLMVTSKGIAGVPGVSFVVLLATLGTVGIPIEGLAFIAGIDRILDMARTVCNVVGNTLATIIVSKWEGKYDKEKGEAYLAEISGGGHDSKDHKYVTES
>NC_016023.1|WP_014097211.1|2131648_2132794_+|metallophosphoesterase
MGKKMLLWAAVLSLALFPRTEHADAAFWFQPKRATVDLRLLETSDLHGYMLNYDYAARTEAETYGLALTASLIAAERKAAKNTMLFDDGDLLEGSEMAAYAARRPLKKGEIHPFIRVMNHLNYDAATVGNHDFHYGLDFLKQTISGAKFPFVNANIYYNFEKNDTDDQNFFKPYVILNKKVEDRHGHSHHLKIGVIGFVTPSVIEWEKPSLGGKVKAKDILHTAAWFVPRMKAEGADLIIALAHCGVDPAAKQPFYTGDAVYLLSEVKGIDAILFGHQHRVFPSEFFAGVPGVDIRKGTINGVPAVMPGKWGSHLGVISLTLEKKGEKWEMTEAQSEAKPVYATHNQQAKSIVRPDPDIVRMTAELQKNVLGSKFTLYSRN
>NC_016023.1|WP_014097212.1|2132949_2133801_-|MurR/RpiR-family-transcriptional-regulator
MGTQLQSFPCLHRIQTMYSEFSAKERKIADYILENPQRLVHSTINQVADQLLVADATVFRFCKRIGFSGFQALKIALAAEAARPGKNMDEAVKDTDNEKAVAIKVFESNIETLQDTIHTLNQKHLHEAVEWICRAKHIVFYGCGSASVIALDALEKFLQTDLAVTAYTDPHLQLLSAARCTKEDVAVFISHAGADKEMLKLLQAVQKTGAKTIAITQFAKSPLSQKADVPLFTVSQEADFRFSSFSARIVQLSLIDTLYVNVMLRYKDTNEEILQKGKETYTV
>NC_016023.1|WP_014097213.1|2134136_2135051_+|DUF1002-domain-containing-protein
MLKRLGLIWFIAMIALGFSMNGVAKASGDNSTVIDEKYGKPIVVTGAALSASQKAEVEKELGVDDANNVEEITVTGDDLVHYIPDGNRNSNMYSSAKITRTDSGGVQVNIVTPENITEVTADMYKNALLTAGIKNAEVEVASPLKVTGHSALVGIYKAYDDSSKSGDKLDSDRTEVASQELSVATDLAKKEGLSNDKVTQLLTEIKQEIADQHPATKEDIEKIVDDKLKDLNINLSDSDRQLLYDLFDQMRKLNINFDSVKSELSSLSDKLSDKINKAAGDKGFWQSVKDFFQNIFDAIRGLFQ
>NC_016023.1|WP_014097214.1|2135073_2135979_-|hypothetical-protein
MVRQVKKTKSFLLTAVFIAFNFCFFTNISVAESPATDGFIIEADRVEGVMLPPGITAGDTATKQNQVMLRLQYADVTIYGLKITKVLQTPGGPVTIHMNAPGPIQLKNMKADATKVDFGSIYVPEKAGQIGMKNVRLVAHQQLADNADLPGLDLSMETGAANFDTSGSDEETLRKQADQLTQLLKGGTPEQNKEEKNGKSDTADKAKADTQDKAKTETQDTKKQHDAKTDGKVTDQNKNKKSENADDTKTKNAEETKSDNTGTKPASGQGTEQNGTPAKTAPGQSSTDKNVQQKEGSSAGN
>NC_016023.1|WP_014097215.1|2135994_2136417_-|hypothetical-protein
MGKFHMFRMKFRNWRRSRPFWGATFTLLSGMIILYVPVQLLEIAAAPGSMVSIGLIFGGLIFLIGGMGYFFPKFNMVFGILAIFLSVLSIMGAMGGFFIGTLLGIIGGSLSVSWRVIRQEEVLASVGPMEEIAAGSAEER
>NC_016023.1|WP_014097216.1|2136441_2137050_-|hypothetical-protein
MNEGALVLQGQGRTSKKWFFTALLSGLIFLGGLLAVLGINGVAVAATVGGIGKFNVSFKQMQGTGFKLYGSLYGDPSKGEDHVKPVFVNEIDKVTIQDLVISKDVKIPVLGDYQVKITAGDGNTPVHLNGLIQKAALVQGDAVFTNMNISENYVTADDPQAASKAFTQGADTLTIKNGSLDTHYLFQKVANLPNLKVQFVKK

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Crispr_ID: NC_016023_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016023_14

2307511-2307617

Orphan

Consensus_repeat	Method
GGTTCTGAATTTGCCAGCGAAACGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_016023_14

>merge|NC_016023|14|2307511-2307617|CRISPRCasFinder
GGTTCTGAATTTGCCAGCGAAACGAATGCGCAGGAAGTAAGAAAGCAAAACGCGAAGTCTGCTTCCGGCCAAGGTTCTTTCGGTTCTGAATTTGCAAGCGAAACGAA

>NC_016023|14|13|2307511-2307617|CRISPRCasFinder
GGTTCTGAATTTGCCAGCGAAACGAA	TGCGCAGGAAGTAAGAAAGCAAAACGCGAAGTCTGCTTCCGGCCAAGGTTCTTTC
GGTTCTGAATTTGCAAGCGAAACGAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_016023.1\|WP_014097374.1\|2310808_2311888_+\|DUF871-domain-containing-protein	unknown	unknown	gnl\|CDD\|377567
NC_016023.1\|WP_014097375.1\|2311878_2312766_+\|N-acetylmuramic-acid-6-phosphate-etherase	unknown	unknown	gnl\|CDD\|235467
NC_016023.1\|WP_014097382.1\|2319012_2319654_-\|YitT-family-protein	unknown	unknown	gnl\|CDD\|376838
NC_016023.1\|WP_014097359.1\|2292088_2292406_+\|YfhH-family-protein	unknown	unknown	gnl\|CDD\|378063
NC_016023.1\|WP_014097368.1\|2305423_2306338_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176125
NC_016023.1\|WP_014097361.1\|2295481_2296462_+\|metal-dependent-hydrolase	unknown	unknown	gnl\|CDD\|224899
NC_016023.1\|WP_014097360.1\|2294184_2295303_-\|A/G-specific-adenine-glycosylase	unknown	unknown	gnl\|CDD\|224115
NC_016023.1\|WP_014097376.1\|2312783_2314253_+\|PTS-transporter-subunit-EIIC	unknown	unknown	gnl\|CDD\|181971
NC_016023.1\|WP_014097379.1\|2316595_2316874_+\|YqhV-family-protein	unknown	unknown	gnl\|CDD\|378514
NC_016023.1\|WP_014097367.1\|2300736_2305299_-\|glutamate-synthase-large-subunit	unknown	unknown	gnl\|CDD\|236968
NC_016023.1\|WP_014097371.1\|2307842_2308097_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372951
NC_016023.1\|WP_014097373.1\|2308882_2310631_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_016023.1\|WP_014097362.1\|2296548_2296707_+\|small,-acid-soluble-spore-protein-K	unknown	unknown	gnl\|CDD\|285399
NC_016023.1\|WP_014097365.1\|2298562_2298871_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|290824
NC_016023.1\|WP_014097377.1\|2314252_2315122_+\|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224651
NC_016023.1\|WP_014097363.1\|2297037_2297913_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NC_016023.1\|WP_014097366.1\|2299000_2300458_-\|glutamate-synthase-subunit-beta	unknown	unknown	gnl\|CDD\|237213
NC_016023.1\|WP_014097372.1\|2308251_2308782_+\|DUF402-domain-containing-protein	unknown	unknown	gnl\|CDD\|184219
NC_016023.1\|WP_014097381.1\|2317639_2318908_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341027
NC_016023.1\|WP_014097369.1\|2306620_2307370_+\|enoyl-[acyl-carrier-protein]-reductase-FabL	unknown	unknown	gnl\|CDD\|236145

Protein	Function_ID	Function_description	E-value
NC_016023.1\|WP_014097374.1\|2310808_2311888_+\|DUF871-domain-containing-protein	gnl\|CDD\|377567	pfam05913, DUF871, Bacterial protein of unknown function (DUF871). This family consists of several conserved hypothetical proteins from bacteria and archaea. The function of this family is unknown.	1.02644e-159
NC_016023.1\|WP_014097375.1\|2311878_2312766_+\|N-acetylmuramic-acid-6-phosphate-etherase	gnl\|CDD\|235467	PRK05441, murQ, N-acetylmuramic acid-6-phosphate etherase; Reviewed.	8.40504e-179
NC_016023.1\|WP_014097382.1\|2319012_2319654_-\|YitT-family-protein	gnl\|CDD\|376838	pfam02588, YitT_membrane, Uncharacterized 5xTM membrane BCR, YitT family COG1284. This is probably a bacterial ABC transporter permease (personal obs:Yeats C).	8.41801e-33
NC_016023.1\|WP_014097359.1\|2292088_2292406_+\|YfhH-family-protein	gnl\|CDD\|378063	pfam08838, DUF1811, Protein of unknown function (DUF1811). This is a bacterial family of uncharacterized proteins. Some of the proteins are annotated as being transcriptional regulators. The structure of one of the proteins in this family has revealed a beta-barrel like structure with helix-turn-helix like motif.	1.98137e-59
NC_016023.1\|WP_014097368.1\|2305423_2306338_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176125	cd08434, PBP2_GltC_like, The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold. GltC, a member of the LysR family of bacterial transcriptional factors, activates the expression of gltA gene of glutamate synthase operon and is essential for cell growth in the absence of glutamate. Glutamate synthase is a heterodimeric protein that encoded by gltA and gltB, whose expression is subject to nutritional regulation. GltC also negatively auto-regulates its own expression. This substrate-binding domain has strong homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.4486e-54
NC_016023.1\|WP_014097361.1\|2295481_2296462_+\|metal-dependent-hydrolase	gnl\|CDD\|224899	COG1988, COG1988, Predicted membrane-bound metal-dependent hydrolases [General function prediction only].	2.963e-38
NC_016023.1\|WP_014097360.1\|2294184_2295303_-\|A/G-specific-adenine-glycosylase	gnl\|CDD\|224115	COG1194, MutY, A/G-specific DNA glycosylase [DNA replication, recombination, and repair].	8.48106e-154
NC_016023.1\|WP_014097376.1\|2312783_2314253_+\|PTS-transporter-subunit-EIIC	gnl\|CDD\|181971	PRK09586, murP, PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed.	4.27199e-94
NC_016023.1\|WP_014097379.1\|2316595_2316874_+\|YqhV-family-protein	gnl\|CDD\|378514	pfam10942, DUF2619, Protein of unknown function (DUF2619). This bacterial family of proteins has no known function.	3.43115e-26
NC_016023.1\|WP_014097367.1\|2300736_2305299_-\|glutamate-synthase-large-subunit	gnl\|CDD\|236968	PRK11750, gltB, glutamate synthase subunit alpha; Provisional.	0
NC_016023.1\|WP_014097371.1\|2307842_2308097_+\|hypothetical-protein	gnl\|CDD\|372951	pfam14182, YgaB, YgaB-like protein. The YgaB-like protein family includes the B. subtilis YgaB protein, which is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length.	3.90547e-24
NC_016023.1\|WP_014097373.1\|2308882_2310631_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	0
NC_016023.1\|WP_014097362.1\|2296548_2296707_+\|small,-acid-soluble-spore-protein-K	gnl\|CDD\|285399	pfam08176, SspK, Small acid-soluble spore protein K family. This family consists of the small acid-soluble spore proteins (SASP) belonging to the K type (sspK). The sspK are unique to the spores of Bacillus subtilis and are expressed only in the forespore compartment of sporulating cells of this organism. The sspK gene is monocistronic and transcription is primarily by the RNA polymerase with the forespore-specific sigma factor, sigma-G. Mutation deleting sspK results in loss of SspK from the spore but had no discernible effect on sporulation, spore properties or spore germination.	6.9293e-19
NC_016023.1\|WP_014097365.1\|2298562_2298871_+\|hypothetical-protein	gnl\|CDD\|290824	pfam14118, YfzA, YfzA-like protein. The YfzA-like protein family includes the B. subtilis YfzA protein, which is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 100 amino acids in length.	0.00032492
NC_016023.1\|WP_014097377.1\|2314252_2315122_+\|MurR/RpiR-family-transcriptional-regulator	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	8.85916e-68
NC_016023.1\|WP_014097363.1\|2297037_2297913_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	5.62761e-69
NC_016023.1\|WP_014097366.1\|2299000_2300458_-\|glutamate-synthase-subunit-beta	gnl\|CDD\|237213	PRK12810, gltD, glutamate synthase subunit beta; Reviewed.	0
NC_016023.1\|WP_014097372.1\|2308251_2308782_+\|DUF402-domain-containing-protein	gnl\|CDD\|184219	PRK13662, PRK13662, hypothetical protein; Provisional.	7.44715e-130
NC_016023.1\|WP_014097381.1\|2317639_2318908_+\|MFS-transporter	gnl\|CDD\|341027	cd17474, MFS_YfmO_like, Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily. This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.63375e-100
NC_016023.1\|WP_014097369.1\|2306620_2307370_+\|enoyl-[acyl-carrier-protein]-reductase-FabL	gnl\|CDD\|236145	PRK08063, PRK08063, enoyl-[acyl-carrier-protein] reductase FabL.	6.2166e-156

>NC_016023.1|WP_014097369.1|2306620_2307370_+|enoyl-[acyl-carrier-protein]-reductase-FabL
MANKVALVTGSSKGLGRAIALDLAKDGYDLVINYARSRSKAEEVAAEIEKMGQKALLIKANVGDVKKIKEMFAQIRDTYGRLDVLVNNAASGVERPAMELEDRHWDWTMNINSRALLFCAQEAAKLMEENGGGKIVSLSSLGSIRYIENYTAVGVSKAALEALTRYLAVELAPSICVNAVSGGVLNTDALKSFPNREVLLEDARKHTPAGRMVEVEDMVNAVRFLISDEAFMIRGQTIIVDGGRSLLLS
>NC_016023.1|WP_014097368.1|2305423_2306338_+|LysR-family-transcriptional-regulator
MIRMELRQLIYFIEVAKREHVTHAADELHVAQSAISRQISLLEAELGVSLFWREGRNVRLTPIGKVFLEHAEKVVLEIDKAKQRMHEFLDPDNGTVRLGFSTGLSVQTFSSLLAQFREKHPGLEYQFVQGTPSYLIRLIENGELELALASPVPDDHPAVSGEILYMEKLMLLFRRDHPLSGQKMIRLAQLKNERFITFREGFSIREILFAACRKSGFEPAIAFEGEDMETIKGLVASGTGVAILPEPALLFNLSEEIVKAEISDMELMRPVGVMIPKKREMAASEKALYTFLTSFYDRLNRFQR
>NC_016023.1|WP_014097367.1|2300736_2305299_-|glutamate-synthase-large-subunit
MNNQHYGLYRPEFEHDACGIGFYADIKGRASHKIITTALEMLRRLDHRAGKNADGTTSDGAGISMQIPHAFFEAVCSFTLPKKGEYAVGMLFLPHDPDAAEEILNEFRIQAASLGLSVPGVREVPVNPEVLGRQAEESRPHIVQIFVSSSNDNTEEAVFQRKIYILRKLVENKFGSSFYAASFSNRTIVYKGMLSAEQLPLFYIDLQDERFQSALALIHSRFSTNTFPSWERAHPNRMIAHNGEINTIKGNVNWFNAKIELFANELGLDTLKKIQPVINANGSDSAIFDNVLEFLTTNGISLPHAIMMMVPEPWEDNEDLPPYLKSFYEYHSQIMEPWDGPMALEFTNGKQIGAVLDRNGLRPARYYITHDDKIIFASEVGVVDVEPENVKERRHLKPGQLLFVDLEKGALIPSDELKAQVSLEKPYAEHLEDSVIDLEESHFIPAASSLEKNELAYRQTLFGYTYEECTKSIVPMAQEKNEPIGAMGVDTPIAVLSERPQLLFHYFKQSFSQVTNPPIDSIRESYVISTVTWLGPQVSLDGHDDTAHKKIRLEHPFLSTDKFNAILNQGMKTAFLPAYYSPDITLEEALEQLLKEADEKIGEGAEILILSDRAQGHRAVPIPSLLAVSALHQHMIRLGTRPKASIVLDSGEPRDSHHMAALLGYGADAVHPYLALETIQNLIDEGHIDLPYKKASENYLSTLKKSVVKIMSKVGITTMQSYRGAQTFEALGIAESVCDRYFTGTVSQLGGIGLAEIGQESLKRYEKAQELLFQHNKALDPGSELQWRKDGEYHLFNPQMMYTLQQAARTNNKELYRKFSETYHHGPYATIRSLLAIESNRKPVPLDEVEPVESIWKRFKTGAMSYGALSKEAHEALAIAMNRIGGKSNSGEGGEEKERYTPDANGDSRRSAIKQVASGRFGVTSLYLTDADEIQIKMAQGAKPGEGGQLPGSKVYPWIAEVRGSTPGVGLISPPPHHDIYSIEDLAQLIYDLKSANPRARISVKLVAKSGVGTIAAGVAKGLADTILISGHDGGTGASPQTSIKHAGMPWELGLAETHQTLTLNGLRNRVVLETDGKLMTGRDVVIAACLGAEEFGFSTAPLVVLGCIMMRACHLDTCPVGVATQNPKLRAKFMGKPEYVVNYMRFIAEEVREILAECGYRSLDELVGETGLLKVKDEVKNHWKAKQLHFDKLLFKADETPFAVQGKTVQNHKLEERFDSRELNHLSVSVRNRQQTAVTLSVRNTDRAIGTTLGHIITKTYGDEGLPEDFIHIHLHGSAGQSLGAFIPKGLTLNLEGDANDYVGKGLSGGKIVVKPGAGWIRDEEQAIIGNIAFFGATSGEAYIRGTAGQRFCVRNSGVHAVVEGIGDHGCEYMTGGRVAVLGSIGKNFAAGMSGGIAYIYTGAMGEDEVLARINQELVSIEGVDADEDMRELYHMIQKHYQYTGSPVAKRILKNWELSLHQFVKIVPREYKAMMELIQYFLDQQMPLDEARLAAFEYKKSGKHLPEIEKEKAFPTEVK
>NC_016023.1|WP_014097366.1|2299000_2300458_-|glutamate-synthase-subunit-beta
MRGTTDFIEQKREKPKELDAAKRVATWKEYVQAFPEAKLRTQASRCMECGTPFCQMGELIGRQTSGCPLYNLIPEWNTLAAQGKWEEAYQRLLLTNNFPEFTSRACPAPCEGSCTAGLVSEPVTIKSIERAIIDRAWEEGWIKPRIPLKRNGLKAAVVGSGPAGLTAADDLNQAGYDVTVFEKEDRFGGLLMYGIPNMKIEKQYVERRVDLLQAEGITFKANTEIGKDITLDELESAFDAVLLCIGAEKQRDMDIPGRDLKGIYPAMEYLKANTKHLLDHGENGEPQISAKGKKVIVIGGGDTGADCVATAIRQGCKSVVQFGKHGELPKERPEHEPWPVNPSLFTLDYAYEESFKVFGEDPRQYYIQTTAFHGNENGEVTGLVTVPFSDPRGAEQQVWEADLVLIAIGFQGVDDSKSAGIELQNGLIQTLPGSFQTNREGIFAAGDAKRGASLIVWAMQEGKKAAKEIDLYLSQKDKATCQPSA
>NC_016023.1|WP_014097365.1|2298562_2298871_+|hypothetical-protein
MAKAVKNGHAKAAKKRYGWYIHLLIFVVAQLVFFIFDNVSASKNIFNLNDYGKWAVSALSPIYDWLQIYKSPQFNLIFVIWGAILIIDGLIRMLPKRHSYSQ
>NC_016023.1|WP_014097363.1|2297037_2297913_+|ABC-transporter-ATP-binding-protein
MEYALEIEGLCKSFSKSRFALKNISFSVPYGSITGFIGENGAGKTSTMGAILQTLHIDSGSIKIFGERIAEAKKEINNHIGVVYDAMNFSGNLDVIKLSKVFRYLYHNWDNQEYFNYIELFSLPKKQKINSFSRGMAMKLSIAVALSHGARLLILDEATSGLDPVGREDVLEALLKFVRDQKGAILLSSHITSDIEKVADTLVFIKKGEIVLKTSKNDLLNNYAIIQCKENELNDLRLNGIIAYKNQTDYVDVLVSNKNELPAKFHKKNFSIDDITLLLMKGENYERAHFK
>NC_016023.1|WP_014097362.1|2296548_2296707_+|small,-acid-soluble-spore-protein-K
MRNKEKGFPYHHDNVYEGKPRAKAEYASKRADGTTNTHPQERMHASGRRGES
>NC_016023.1|WP_014097361.1|2295481_2296462_+|metal-dependent-hydrolase
MDTGTHVVMGFALGGLATLDPVVAQDAVHFHSVLIATVLGSQAPDIDTLLKFKNNAVYIRNHRGITHSVPAVLLWPLAITAVLSIFFPGTDALHLWLWSFLAVFLHVFVDIFNAYGTQALRPFSYKWVALGVINTFDPFIFTIHVIGIAAWLFGAQPGPTFLAMYIFIFLYYIARFAARHDVKKAVLARIPDAENIIISPTVRFHQWKIAVRTKDAYYVASAFKSAVTILDKFKRLPVPENEIIEAAKQDKNLSAFLSFSPVYNWQVKELDNGWEVRFTDLRYRKNGHYPFVAVVKLNEDLEITGSYTGWIFNKKKLKKKLDVVPR
>NC_016023.1|WP_014097360.1|2294184_2295303_-|A/G-specific-adenine-glycosylase
MKNLPIDDFDIKSFQDDLISWFEREQRKLPWREDRDPYKIWVSEIMLQQTRVDTVIPYFRRFMEKFPTIEALADASEDEVLKAWEGLGYYSRVRNLHAAVKEVEEHYGGTVPDTPEEVSKLKGVGPYTAGAILSIAYGLPEPAVDGNVMRVLARILSIWEDIAKPSARKVFEEVVRKLISRENPSFFNQALMELGALVCTPKSPSCLLCPVREHCRAFREGTIDELPVKSKGKKQKQIRLQAAVLEDEDGRILIHKRPDKGLLANMWEFVQVEESTVLPARQVLKDYLGDVFKIEAALETEHFTEIRHVFTHLIWDIRVYRGKIINQVQETNELKCVPPDEIETFAFPVPHQKIWKAFREQAKSEKVKDIKG
>NC_016023.1|WP_014097359.1|2292088_2292406_+|YfhH-family-protein
MEKRYSEMSEYELKQEIAQLTEKARKAEQLGIVNEFAVLERKIAMAKSYLLDPASFQKGEIYEIEGDPGVYFKIDYIDGVFAWGYRVSGGKPIEALPISMLKPVD
>NC_016023.1|WP_014097371.1|2307842_2308097_+|hypothetical-protein
MMEEFNRLVAQQMDTMDRLLFLQSEMERCNEVKSELLKLQEETMAEDILDEIGRMNKELQEIEKVFESQTVELIRVYHSSKICT
>NC_016023.1|WP_014097372.1|2308251_2308782_+|DUF402-domain-containing-protein
MGIPAEGDKIQIQSYKHNGHIHRIWEETTVLKGTKSLVIGGNDRTLVTESDGRTWITREPAICYFHADHWFNIIGMIREDGVYYYCNLGSPFVYDSEALKYIDYDLDIKVYPDMTFTLLDEDEYEYHRKKMGYPDVIDHILKRNVDILIHWIRQRKGPFSPDFIDIWYERYLTYLR
>NC_016023.1|WP_014097373.1|2308882_2310631_+|ABC-transporter-ATP-binding-protein
MGSVKRYMKFVKPYWFQIVATIIIGIIKFTIPLLIPLLIKYVIDDIIGNHGLSPDEKLHKLVWVMSFMLAIFVIVRPPVEYYRQYFAQWTASKILYDIRDRFFTHLQKLSFRFYANTRGGEVISRVMNDVEQTKDFVITGLMNVWLDMTTVLIAIVMMFMMDARLTLISLAVFPFYIFSVKYFFGNLRFLTRKRSQALAEVQGYLHERVQGMAVIKSFAIEDHEQKQFDKHNHNFLEKALAHTSWTAKSFAVVNTITDIAPLFIIFVSGYLVIKGSLTVGTLAAFIAYIDNLYSPLRRLVNSGTTLTQAFASMDRVFELLDEKYDIDDRPDAVECRNVRGNIRFDGVEFRYDDEKEPVLKNINLEIRAGETVAFVGMSGGGKSSLVSLIPRFYDVTKGAVYLDGQDIRTFKVRSLRDKIGMVLQDNILFSESVKSNILLGNPQATDEEVVQAAKAANAHEFIMNLADGYETTVGERGVKLSGGQKQRIAIARVFLKNPPILILDEATSALDLESEHLIQEAIEKLARNRTTLIVAHRLSTITHADRIVLIENGEIKETGTHEQLMAKQGLYYNLFQIQQLDD
>NC_016023.1|WP_014097374.1|2310808_2311888_+|DUF871-domain-containing-protein
MLGFSIYLNEDWSEEKEACIHRMAAIGMEGIFTSLQLPEDDPSQYRKRLAPLLEAAKRNGMKVMIDISGNVLHHIGLSIDDPARIIESGINGLRIDAGVSWEQVARLSNTMTVGLNASTLTEQDYEQLKQHGANFRRLEAWHNYYPRPGTGLDENWFYEKNKWLKSKGFSITAFAPGDGKLRFPLYESLPTLEIHRHQNPLAAICSLLRDYAVDHAYIGDPGLTPQSRSQIGEFFCHDTILLHATAADPKWRPYIFKNHRNRMDVARDAIRSEQSRTCNQKDDIGPENNIPRNKGSITLDNNLYARYKGELQITKRNLPADAKVNVIGQIAGRDLPLLDFIGSGTQFKMTDNEGENEWT
>NC_016023.1|WP_014097375.1|2311878_2312766_+|N-acetylmuramic-acid-6-phosphate-etherase
MDLEKLATEQRNEKTMNLDTLSTKEILQLMNEEDQTVPIRVGKELAQIEKVVKAVIRSFNQGGRLIYCGAGTSGRLGVLDAVECVPTFSADPSMVQGLIAGGTAAMTVAVEGAEDSKEMGEEDLRHIHLSEKDTVIGIAASGRTPYVIGALDYAKKAGAVTASLSCNKNAEISRHADIPIEVETGPEVLTGSTRLKAGTAQKLVLNMISTAAMVGIGKVYENLMVDVKPTNAKLVERSKSIIMQASGCSYEAAEQAFYAAGKNVKLAIVMLLTHLSKEEAEEKMAQANGFIRKIV
>NC_016023.1|WP_014097376.1|2312783_2314253_+|PTS-transporter-subunit-EIIC
MTETKEQRLAREIYENVGGMGNVEKIIHCMTRVRLTIADYSKVNIEGLKAVDGVLGVVEDETLQVVLGPGIVNKVANLMVHEAGVKLGENFPKSAGHKDAGRSNREMAEAKAAEVKAREKAKHKSNGFKRALKSISNIFVPLIPAFVGAGIIGGVAAIFQNIMAADSSALSQNWVSVITTLNIIKNGLYLYLVIYVGINSANEFGATPGLGGVIGAVTMLTGMDPKNPLPNIFNGDALSPLQGGIIGVIFAVWILALVEKRLHKIVPNAVDIIVTPTIALLVIGLFTIFIVMPVAGAVSGALVGSITWVLKVGGAFSGFILGLFFLPMVMFGLHQILTPIHIEMINKTGMTPLLPILAMAGAGQVGAAIALWIRCRKNKKLVQLIKGALPVGIMGIGEPLIYGVTLPLGRPFITACIGGGIGGAVIAGIGNIGAIAIGTSGIDLIPLIAHGRWLGYIAGLVAGYIGGFVATYFFGIPKDAMKETDADRE
>NC_016023.1|WP_014097377.1|2314252_2315122_+|MurR/RpiR-family-transcriptional-regulator
MELDENIILQIKSKLTSLSKSEKKLGEYILSHAVETVNDNTSELAKKAGVSPATVVRFCRSIGLSGFSQLKIRLYADASGGLDREIYTDITPNEDITMIADKLALRFNQSITQTANLLETSCIEKITAMVDKSPAIYVYGIGASHVAAEDFTHKFSRIGKPVVHTLDHHLLGSSLINASKDCMFVAISNSGETNEAIKLTQIAKQNGLFTVGITQKRDSTLASIVDAPLIHHGGEAVLLRSAATTSLAAQLFTIDVLYFAYVAKHYHEIMGRLKNSKINIQTFFRKENN
>NC_016023.1|WP_014097379.1|2316595_2316874_+|YqhV-family-protein
MLWLIEKYVLSMAALRLISGMIEISAAILMLKYNQVEKALLINSSLAIVGPVVLITTTAIGVIGISDKISFAKMLWILAGVGCILYGIKSNG
>NC_016023.1|WP_014097381.1|2317639_2318908_+|MFS-transporter
MASKQPSVMTVAAIGSIPLIMTLGNSMLIPVLPKMQSELHLTSFQASLTISVFSIVAAVFIPVLGYLSDRFSRKAVILPALFLYGAGGILAGIAAALFSHAFAWILAGRTLQGIGAAGTAPIAMALTGDLFKGDKESRVLGLVEASNGFGKVLSPILGALIALLVWYGTFFAFPVVVAVSIFLTWVFIKEKPKKKEPPGLGKYVKGLAGVFKDDGRWLCTAYLAGATCLFTLFGILFFLSNVLEKSYKIDGVMKGLILAIPLLVMCTTSYITGSKIGKNQRLMKKLIVTGFCLMTLSYALLTFFRGLFLFIPVLAIGSLGTGLILPCVNSFITNAVGKEKRGFVTSLYGSVRFLGVAVGPPVFGRLMAWSRPGMFISIACFTFAVGLLSLLLIRPQTEKGSSGGEEKKKRSRHTILEPVGGR
>NC_016023.1|WP_014097382.1|2319012_2319654_-|YitT-family-protein
MKKQHSRNVKKLLMIMAGAALQGYSMGVFLFPNAIPSGGAGGLTVLFHHWFHVPLSIALWMLNSSMLVFAVYFLSAASAMGTLLGITVTSVSVNLSAFLWETPFHNEWLDLALGSVLLGIGIGILLRQGVSNGGIGIVALIISKYRSVNPATPLFIINGLIFILTAYVIDWEIVVQAVICQYVSTRIVGWIYQFSFQAIYLKLPFLPLGWRKK

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Crispr_ID: NC_016023_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016023_15

2540824-2540911

Orphan

Consensus_repeat	Method
TCGACAACAATTAGCGCCCATGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_016023_15

>merge|NC_016023|15|2540824-2540911|CRISPRCasFinder
TCGACAACAATTAGCGCCCATGCATGCAGCGCCATCAGTGGATTGGCAAAGACAAAAAAGAGAGGTCGACAACAATTAGACGCCCATG

>NC_016023|15|14|2540824-2540911|CRISPRCasFinder
TCGACAACAATTAGCGCCCATGC	ATGCAGCGCCATCAGTGGATTGGCAAAGACAAAAAAGAGAGG
TCGACAACAATTAGACGCCCATG

Protein	Signature genes	Signature genes Name	Protein_function
NC_016023.1\|WP_014097583.1\|2542409_2543555_+\|N-methyl-L-tryptophan-oxidase	unknown	unknown	gnl\|CDD\|236887
NC_016023.1\|WP_014097585.1\|2544944_2545727_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235546
NC_016023.1\|WP_014097584.1\|2543616_2544087_+\|divergent-PAP2-family-protein	unknown	unknown	gnl\|CDD\|376897
NC_016023.1\|WP_014097589.1\|2550303_2551719_+\|ISLre2-family-transposase	unknown	unknown	gnl\|CDD\|284250
NC_016023.1\|WP_014097588.1\|2548048_2550100_+\|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl\|CDD\|223910
NC_016023.1\|WP_026685163.1\|2552200_2553349_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380483
NC_016023.1\|WP_014097587.1\|2547139_2547826_+\|glycerol-acyltransferase	unknown	unknown	gnl\|CDD\|153244
NC_016023.1\|WP_014097581.1\|2539170_2540640_+\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|143449
NC_016023.1\|WP_014097571.1\|2530083_2531115_+\|NADH:flavin-oxidoreductase/NADH-oxidase	unknown	unknown	gnl\|CDD\|239242
NC_016023.1\|WP_014097577.1\|2533869_2534100_-\|DUF378-domain-containing-protein	unknown	unknown	gnl\|CDD\|225066
NC_016023.1\|WP_014097579.1\|2535723_2536725_-\|potassium-channel-protein	unknown	unknown	gnl\|CDD\|369572
NC_016023.1\|WP_014097574.1\|2532686_2532884_-\|hypothetical-protein	unknown	unknown	unknown
NC_016023.1\|WP_014097586.1\|2546052_2547147_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133022
NC_016023.1\|WP_014097580.1\|2538226_2539156_+\|ornithine-cyclodeaminase	unknown	unknown	gnl\|CDD\|236313
NC_016023.1\|WP_014097582.1\|2541167_2542334_+\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223737
NC_016023.1\|WP_014097573.1\|2531984_2532371_+\|general-stress-protein-13	unknown	unknown	gnl\|CDD\|181215
NC_016023.1\|WP_014097576.1\|2533246_2533717_-\|GyrI-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|226231
NC_016023.1\|WP_014097572.1\|2531509_2531719_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NC_016023.1\|WP_041818104.1\|2553543_2555145_-\|FGGY-family-carbohydrate-kinase	unknown	unknown	gnl\|CDD\|198356
NC_016023.1\|WP_014097578.1\|2534256_2535606_+\|glucose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|184504

Protein	Function_ID	Function_description	E-value
NC_016023.1\|WP_014097583.1\|2542409_2543555_+\|N-methyl-L-tryptophan-oxidase	gnl\|CDD\|236887	PRK11259, solA, N-methyl-L-tryptophan oxidase.	0
NC_016023.1\|WP_014097585.1\|2544944_2545727_-\|SDR-family-oxidoreductase	gnl\|CDD\|235546	PRK05653, fabG, 3-oxoacyl-ACP reductase FabG.	1.03198e-105
NC_016023.1\|WP_014097584.1\|2543616_2544087_+\|divergent-PAP2-family-protein	gnl\|CDD\|376897	pfam02681, DUF212, Divergent PAP2 family. This family is related to the pfam01569 family (personal obs: C Yeats).	8.15351e-63
NC_016023.1\|WP_014097589.1\|2550303_2551719_+\|ISLre2-family-transposase	gnl\|CDD\|284250	pfam06782, UPF0236, Uncharacterized protein family (UPF0236).	2.27127e-46
NC_016023.1\|WP_014097588.1\|2548048_2550100_+\|methyl-accepting-chemotaxis-protein	gnl\|CDD\|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	1.47101e-54
NC_016023.1\|WP_026685163.1\|2552200_2553349_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|380483	cd01541, PBP1_AraR, ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators. Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators. The ligand-binding domain of AraR is structurally homologous to the periplasmic sugar-binding domain of ABC-type transporters and both domains contain the type 1 periplasmic binding protein-like fold. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the type 1 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.	1.85742e-112
NC_016023.1\|WP_014097587.1\|2547139_2547826_+\|glycerol-acyltransferase	gnl\|CDD\|153244	cd06551, LPLAT, Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis. Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).	0.000168392
NC_016023.1\|WP_014097581.1\|2539170_2540640_+\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|143449	cd07131, ALDH_AldH-CAJ73105, Uncharacterized Candidatus kuenenia aldehyde dehydrogenase AldH (CAJ73105)-like. Uncharacterized aldehyde dehydrogenase of Candidatus kuenenia AldH (locus CAJ73105) and similar sequences with similarity to alpha-aminoadipic semialdehyde dehydrogenase (AASADH, human ALDH7A1, EC=1.2.1.31), Arabidopsis ALDH7B4, and Streptomyces clavuligerus delta-1-piperideine-6-carboxylate dehydrogenase (P6CDH) are included in this CD.	0
NC_016023.1\|WP_014097571.1\|2530083_2531115_+\|NADH:flavin-oxidoreductase/NADH-oxidase	gnl\|CDD\|239242	cd02932, OYE_YqiM_FMN, Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing agent. The YqjM enzyme exists as a homotetramer that is assembled as a dimer of catalytically dependent dimers, while other OYE members exist only as monomers or dimers. Moreover, the protein displays a shared active site architecture where an arginine finger at the COOH terminus of one monomer extends into the active site of the adjacent monomer and is directly involved in substrate recognition. Another remarkable difference in the binding of the ligand in YqjM is represented by the contribution of the NH2-terminal tyrosine instead of a COOH-terminal tyrosine in OYE and its homologs.	2.30201e-174
NC_016023.1\|WP_014097577.1\|2533869_2534100_-\|DUF378-domain-containing-protein	gnl\|CDD\|225066	COG2155, COG2155, Uncharacterized conserved protein [Function unknown].	3.96639e-24
NC_016023.1\|WP_014097579.1\|2535723_2536725_-\|potassium-channel-protein	gnl\|CDD\|369572	pfam07885, Ion_trans_2, Ion channel. This family includes the two membrane helix type ion channels found in bacteria.	8.52484e-13
NC_016023.1\|WP_014097586.1\|2546052_2547147_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|133022	cd04179, DPM_DPG-synthase_like, DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily. DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.	7.49727e-39
NC_016023.1\|WP_014097580.1\|2538226_2539156_+\|ornithine-cyclodeaminase	gnl\|CDD\|236313	PRK08618, PRK08618, ornithine cyclodeaminase family protein.	7.5017e-74
NC_016023.1\|WP_014097582.1\|2541167_2542334_+\|FAD-binding-oxidoreductase	gnl\|CDD\|223737	COG0665, DadA, Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism].	6.70018e-63
NC_016023.1\|WP_014097573.1\|2531984_2532371_+\|general-stress-protein-13	gnl\|CDD\|181215	PRK08059, PRK08059, general stress protein 13; Validated.	2.28587e-67
NC_016023.1\|WP_014097576.1\|2533246_2533717_-\|GyrI-like-domain-containing-protein	gnl\|CDD\|226231	COG3708, COG3708, Uncharacterized protein conserved in bacteria [Function unknown].	3.69699e-17
NC_016023.1\|WP_014097572.1\|2531509_2531719_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	9.41172e-11
NC_016023.1\|WP_041818104.1\|2553543_2555145_-\|FGGY-family-carbohydrate-kinase	gnl\|CDD\|198356	cd07778, FGGY_L-RBK_like, L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases. This subfamily is composed of a group of putative bacterial L-ribulokinases (RBK; EC 2.7.1.16) and similar proteins. L-RBK catalyzes the MgATP-dependent phosphorylation of a variety of sugar substrates. Members of this subfamily belong to the FGGY family of carbohydrate kinases, the monomers of which contain two large domains, which are separated by a deep cleft that forms the active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain.	0
NC_016023.1\|WP_014097578.1\|2534256_2535606_+\|glucose-6-phosphate-isomerase	gnl\|CDD\|184504	PRK14097, pgi, glucose-6-phosphate isomerase; Provisional.	0

>NC_016023.1|WP_014097581.1|2539170_2540640_+|aldehyde-dehydrogenase-family-protein
MEKYLNYIDGEWCEPSTGKFAPVVNPANGKTLGEVAQSAEPDLDRAVQAAKSAQSVWRLVPAPERANYLYKVGELLKQRKEQIARTLTSEMGKVIDEARGEVQEAIDMAFYMAGEGRRQFGDTVPSELQNKFAMSIRVPVGIAGLITPWNFPIAIASWKSLPALVTGNAVIWKPATETPATACAFVKIYEEAGLPKGLVNLVHGSGSVIGEAMVEHPGIGLISFTGSNEVGRKINERAGGLLKRTSLEMGGKNAVIVMDDADLDLAVDGILWGAFGTSGQRCTATSRVIVHKKIKDALEEKLIRRTAELKIGDGLDETVAVGPVINTEALNRIHQYVETGKKEGARLLTGGRILPGKGYYYAPTVFTDVSPEMVIAQEEIFGPVVSIIPVASLEEAIVVNNSVTFGLSSGIFTKDVNKAFQAMRDLDTGIVYINAGTTGAEIHLPFGGTKGTGNGHRDSGPAALDVYTEWKAVYVDFSGKLQRAQIDNN
>NC_016023.1|WP_014097580.1|2538226_2539156_+|ornithine-cyclodeaminase
MLVLNGCDVLKAASMQEMMAAVEKAYRIYEENGYQMPLRTHFTIRDNSVLFMPCSTNEAAGAKIVSVFPDNKDRPVTQGAVLLVDSRNGSMKTLMDGTVLTGLRTGAIGGAAAKYLAPSDAKTAGLIGTGYQGLYQLAGVCTARNIENIFLFNRTPSNIPPFIRRFKTLIPNIPVHIAKSARELAEKADILITATSSATPVLPEEDLYDGKLVIGIGSYQPHMREFPDALLKNLKSIYIDSHDAAKESGDVDSRLKTIPFSKIVTQKVKPDPNTLQVFKSTGMALFDLVAAETVYKKAIQLGIGQMLDF
>NC_016023.1|WP_014097579.1|2535723_2536725_-|potassium-channel-protein
MFHLFYYRFLRWPIIVRILNLALAVIFAFGLAIHFVEPKTFPTVFDGIWWAVITTATVGYGDLYPVTLAGRLIGIILILSGAGILSAYFVALAGATATRQNAFLEGKAAFTGGKQMVIIGWNERARKVIGQLMELKERQPVVLVDETLESNPYPYDNVYFIKGKPYQDETLKKANVKAAKAVLITSDQHKTETEADMGAVLTLLAVKGLNPDAYCIVEIQTADQVVNAKRAGADEVIQANTQASFVMLNSLISNGMSDTLLSLLNQQEKNHLDFIPVKPKWRNLTVKDLSRQLQKERKILIGIQSGDDTMINPPLDYTITDEEHLFVVLEKDK
>NC_016023.1|WP_014097578.1|2534256_2535606_+|glucose-6-phosphate-isomerase
MTHIQFDYSKALAFFNEHEITYLSEPIRLAHKLLHEKTGVGNDFTGWLTLPKDYDKEEFARIQKAAAKIQNDSDVLLVIGIGGSYLGARAAIEMLNHSFMNVLPKEKRKNPQIFFVGNSISSTYMKDLMDVLEGKDFSINVISKSGTTTEPAIAFRIFNKLLIEKYGEKEAKGRVYATTDRAKGALKTLADAEGYETFVIPDDVGGRYSVLTPVGLLPIAVSGVDIQAMMDGAAKAVDDFSNPEVAENIAYQYAAVRNILYRKGKTIEMLINYEPGLQYFSEWWKQLFGESEGKDQKGIYPSSANFSTDLHSLGQYVQEGRRDLFETVVKVEQAREELTIEKEENDLDGLNYLAGRTVDFVNNKAFEGTLLAHTDGGVPNLVVSIPKTDAYTFGYLVYFFEKACAVSGYLNGVNPFDQPGVEAYKKNMFALLGKPGYEDLKAALEKRLK
>NC_016023.1|WP_014097577.1|2533869_2534100_-|DUF378-domain-containing-protein
MSIVQRIALIFTIIGAINWGLIGFFNFDLVAAIFGDNSAISRVIYGIVGICGLINLGLLFKPDAEVERSTQAKPTR
>NC_016023.1|WP_014097576.1|2533246_2533717_-|GyrI-like-domain-containing-protein
MEIQIVQKHAFNAVGSKWTGTFEQAANGEIKRFFHQFKQKMGKIRHCTDPSVVIGLSYHSQDDEGLFSFYLVREVAYIEAVPEGMTALTVPSYTFAAAKYKGEDVQKAYAELYKWIRKNGYTVFQGQLEHREDYPTSYEPLIDEPELTLYIPLYIE
>NC_016023.1|WP_014097574.1|2532686_2532884_-|hypothetical-protein
MALDVKGEEKAATDVYAKLHKHGDNGDFSGFVFNIGIQNWEEQNEPDWDIPDDFIPLQRNDGDGN
>NC_016023.1|WP_014097573.1|2531984_2532371_+|general-stress-protein-13
MSNYEAGNVYTGKVTGIKPFGAFVALDEETQGLVHISEIKHGYVKDIHDHVHIGNEVKVKVLSVDEENGKISLSIKATEEAPHQDTRKPRRRQGAVKAAEESGEGFNTLRDKLKEWIEKSKREDLIKK
>NC_016023.1|WP_014097572.1|2531509_2531719_-|helix-turn-helix-transcriptional-regulator
MNSFGEKLKFYRELSGMSIEELAVKARIGKHTLEQYETGEQIPTTQTILKLSTVLDVAASVFLEALGKK
>NC_016023.1|WP_014097571.1|2530083_2531115_+|NADH:flavin-oxidoreductase/NADH-oxidase
MNDLFTPYKLKSLEVKNRIVMPPMCQYSVEKKDGVATDWHYVHYVSRAIGGTGLIIMEMTDVEPDGRITDNDLGLWSDEQIAPLAKIVEACHQYGAKVGIQIGHAGRKAQDAKQPVAPSPIPFDDHAKTPRALTKEEIKEIVRKFGESVRRAVQAGFDTIELHGAHGYLIHEFQSRYTNKRSDEYGQDLALFGKEVIAAAKSEMPADMPLIMRISAREYVDGGYGIEESIALSKAYKEAGVDLFHISSGGEGHIGAAGRPGTHAAYQVPLARQIKEALNVPVIAVGRLEDPVLANAVIGNEEADLVAVGRGMLRNPYWALNAGIALGKDAGVPIQYTRGFPKR
>NC_016023.1|WP_014097582.1|2541167_2542334_+|FAD-binding-oxidoreductase
MKNKADVIIVGGGIIGSSVAYHLLADGFAGRIIVFEKDPSYAYASTPRSAGGIRQLFTTAVNIQMSRYSLKAYQNFARDMAIDSETFEIDLKQRGYLFLASEKMMPHFKKHLKLQHQNGVSSEWLGKKELLGLIPELSTRDLAGGLYCAESGYLDPYTAMQGFIKNAKHLGAEYMYEEVDRFLAEEGRIKGVQLKDGRAFFAPVVVNCAGAWASGLSSKAGLLLPVIPVPRRIFMFDVEKPLAKPLPLTMDLTGVYFRHEGRKIIAGYGEEEKPAIDFSWKRSEFEEQIWPILAGRIPNFEKVKVERGWAGLYDYNTADHNAIIGEHPEMKGYFVAFGFSGHGMQQAPAVGKGLSDLIRTGKYETIDLTPLRVERFAENDLVTEDAIY
>NC_016023.1|WP_014097583.1|2542409_2543555_+|N-methyl-L-tryptophan-oxidase
MEKHYDVIVVGAGSMGMAAGYFLARQGVKTLLLDAFDPPHTSGSHHGETRIIRHAYGEGRDYVPLVLRAQTLWDELEKASGEKIFAKTGVLSFSPEDHAAFLNEAIESANTYNLPIKMMTGAEVEKRWPGISLPAGFQAIYEPDAGVLFPENCIRAYRKLAEAKGARLLANTRVTDLKTDGQTVTVVTETGTFTAEKCIVSGGAWNGKLLENLGLNLPLQPVRKTVGWFEADEALFNADVFPAFTMDGYEGTYYGFPSFNGSGVKVGRHDGGQAADPDTMNREFGAYREDEGDIRAFLKTYMRGAAGRLKKGKVCLYTNTPDEHFIIDTHPVYPNVAIAAGFSGHGFKFASSVGEMLSQMVLKENAESPLPLFSINRAALA
>NC_016023.1|WP_014097584.1|2543616_2544087_+|divergent-PAP2-family-protein
MFLSYPILSALLGMLVAQIIKVPIHFITSGKFDWRMAFSTGGMPSSHTSMVIALTTAIGLTSGFGSNAFAISIVFSSIVIYDAIGVRRQAGFHAEVLNQLLADFSRLLDTMKDPGLKNAESRQKLKELLGHKPAEVFFGIITGILTAVLTFLLYPF
>NC_016023.1|WP_014097585.1|2544944_2545727_-|SDR-family-oxidoreductase
MRLKDKVAIITGGGSGIGEASALKLAAEGAKVCVMDIEQKRADEVKRRIEQNGGEAMALEVDVTDPEQVKTAVDKTVREWDRLDIVFSNAGINGTVAPIEDLTPDDWEKTLSTNLKGTFLLTKYAIPHMKNRGGSIIITSSINGNRIFSNIGMSAYSSSKAGQVAFMKMAALELARYKIRVNAVCPGAIETKIEQNTNRTEELEKVQIPIEFPEGDQPLSGRPGKPEEVADLVLFLASDDSSHISGTDIYIDGTESLLRG
>NC_016023.1|WP_014097586.1|2546052_2547147_+|glycosyltransferase-family-2-protein
MIGNVAVVIPALNPEAQLVHYADRLLAKGAARIIVVDDGSSPACAPIFQMLSQKERCTVLHHPANRGKGRALKTAFAHILAHHGSLSGVVTADCDGQHSPEDVEKMAASLRQNPHSIILGARDFSLEHVPPKSRFGNRLTSFLFKALYGAEIGDTQTGLRGIPKQELGWLLALKGERFEYEMNMLIYARKMNVKIREVPIRTIYFNRNEGTHYRPVKDSLKIFRKIISGLFYYAFPALIFLIADILSFSLLYRYVLAGIPHVWKVLAATAASQVVAFAVFLMVKYRLLKWKRFLVRYLMACLLFIVVSFLFIEAGSGLLQFDPVLAKTIASLFLALFFYQLQLHWGIFSGYPEYGQLAGERRHG
>NC_016023.1|WP_014097587.1|2547139_2547826_+|glycerol-acyltransferase
MAKGYGLFFKSVRQLVRFVYPSYKAQISGEIAGPAVYVSHHRNLFGPFVTLLWYPEFIRTWILHVFLDRKSCSRQYADYTFTKRFGLPRALANPAAFFLSFGITKLLKSGRGIPVFRSSRKIIRTFQESVEALKNGESIAIYPDIDYTDNAAGVKGMYEGFLYLEKYFYKATGRHVQFVPLYASKTKRLLVTGTPVFFREGEDFRTEKEVVYEKLHKALNRLAAQYGE
>NC_016023.1|WP_014097588.1|2548048_2550100_+|methyl-accepting-chemotaxis-protein
MKKQKKFIPLTVKWGGLICAAILISILATVGLEYATTSHLLKTKNRGVNQMVANEAASQVEAGLAKYETSLDELAGLVETDLQRKNKMQDIEAEIKSVQTRNKQLASAYYMDFQTGKLHISPYAKLNLDVRNTNTYRYLQKKPQLQWMDIYKDKVTGAIMTSVVAPVFSGGRMAGAVGYDINLSEMGKIRADIEHDSNNKLAIFDAKGVIVTSFLKNGDGKNARPANSGKVEGVKDIESSTRLEKDFAFAEKIYSQKTAAATFHWNGAGYDVYATTIPKTGWKVASFNPQSEFSAQIGKIKKMGLLSIGIGLLIGIVFAVLIAGRLVKIIKNLQQVLAKTAEGDLVTAFAFRSNDEIGELAKSYNAMLHNMRSLIAKVRDSVDAVNKSTAGLRTVTKENEAAVTDVSKAVEDIAAGAANQSDHIETGSNAMRDLGGEIEKLAAQSQVIESAVDQAETEIKSGTKQVDNLEASYQKLEQAFERVTSMMAGLNEKSKSIAQVADVITQIAEQTNLLSLNASIEAARAGENGKGFAVVANEVRSLAEQSKQSAKDIRATIADVLQDMKELVDVVGETNEISTGQKKAVNSVSTSIAVLAEGLEKMLSSIKQEAESIRSIGEQKDAVVQMIEDLSAVSQQTAAASEEISSSMEEQAASAGELSRYTEKLFTLTEELEREIGEFTIKK
>NC_016023.1|WP_014097589.1|2550303_2551719_+|ISLre2-family-transposase
MDIISIIAGLLKGTKSLMEFEEQIKILMQKAFTQWVGEIFEELDKIIKQEKLEEGWVYCRSDNRNIQFLFGSVTFKRSLMHDKRGNSHYPLDEWLGLVPHQRYSPLVELKVAELASENTYREVADILKEWTAVSLSHTTVGNMVKHVGKTQAEADKALVEELEIAVSLPEGKKVDYLFSEADGVFVRGLKKKQSMEVHHAILYEGWETNGKRVSLRQPTVIMTTEDIQTFWDEVQATAANTYSLEKAQVITNSDGGAGYTAERFQTAFSQSEFPVLNQLDTYHVAQAIIRTFGGGKSEIKEQIRKSIRTHDLDQFTLYLDTHESTLTDKKALKKIKEFRSYILKNWDRIFDWRDRVKNVPEGARGLGAMESNQRHISFRMKKRGMHWSELGAEAMVKIKQGILKGTLREAYLKHRSRSERKQRNLKQSIRMSQLLKQPVRPSVGVKHGSVALHSSSSSAMGHLSKILELSF
>NC_016023.1|WP_026685163.1|2552200_2553349_+|GntR-family-transcriptional-regulator
MNMSKKYEKIKQDIREKILTEEYKVSEKLPTESELMEMYQVSRFTVRRAIDELEKENFVYRIQGGGIFVDDWKGKPQTVMKNKTIGLITTYISDYIFPNIITGIDNYVSNYGYSILITNTQNNPEKERKSLSNLLSNKISGLIIEPTKSALSNTNKSIYDNIKSLGIPMLFINAVYDDMNIPYLVMDDLKTGEMVTDYLISLGHKKIVGIFKVDDKQGIHRMNGYIKAFQKHPEISNMGEIMMYQTEENKINLFKKLHTILSRPEFAPTAIVCYNDQLAIQVMNFVKEIGLNVPKDLSVIGVDDYQFSKFINPALTTVRHPQEKMGLDAGKMIIDMLNKQPVTSKIYEPELVKRDSVKPLDHSNDNWTEKNREEKAICDNDE
>NC_016023.1|WP_041818104.1|2553543_2555145_-|FGGY-family-carbohydrate-kinase
MNLIETSQAIQQGNVSLGIELGSTRIKAVLVTDDFETIASGGYVWENKFENGIWTYSLEEVWEGIQRSYAQIAADVQGKYHTTLTKISAIGVSAMMHGYLAFAENGELLMPFRTWRNNITEQAADELTGRFQFNIPQRWSIAHLYQAILNQEPHVKDIRFITTLAGYVHWKLAGEKVLGIGDASGVFPVDEETGTYRKDFLDTFDRLENVTPYPWHIREVLPKVLKAGEYAGTLTTEGAALLDVNGNLQAGSLMAPPEGDAGTGMVCTNSVRKRTGNISVGTSAFSMIVLDQPLEKVYRDIDIVTTPSGAPVAMVHINNCSSDINAWANLFKQFAERLGVDLPADRLYETLFLVAAKADPDAGGLLNYSYLSGENITKMPAGRPLFVRKPDSAFTLANFVQAQLYAAFAPLKIGMDILKNEEGIKTDVLIAQGGLFKTPVIGQQVLANALNTPITVMSTAGEGGAWGMAVLAVYAKSGNGKQSLEDFLDQNVFTHPESMTLSPEPEGVSGYEAFIKRYEAGLPVESMAVKSIG

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Crispr_ID: NC_016023_16

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016023_16

2614634-2614734

Orphan

Consensus_repeat	Method
TGGGTTCGATTCCCATCATCCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_016023_16

>merge|NC_016023|16|2614634-2614734|CRISPRCasFinder
TGGGTTCGATTCCCATCATCCGCCCTTTGCTGCGGGTGTAGTTTAGTGGTAAAACCACAGCCTTCCAAGCTGTTGTCGTGGGTTCGATTCCCATCACCCGC

>NC_016023|16|15|2614634-2614734|CRISPRCasFinder
TGGGTTCGATTCCCATCATCCGC	CCTTTGCTGCGGGTGTAGTTTAGTGGTAAAACCACAGCCTTCCAAGCTGTTGTCG
TGGGTTCGATTCCCATCACCCGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_016023.1\|WP_014097623.1\|2593197_2593608_+\|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|214628
NC_016023.1\|WP_014097633.1\|2606562_2606769_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224393
NC_016023.1\|WP_014097638.1\|2620339_2621158_+\|1,4-dihydroxy-2-naphthoyl-CoA-synthase	unknown	unknown	gnl\|CDD\|180958
NC_016023.1\|WP_014097642.1\|2624838_2625729_-\|zinc-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238499
NC_016023.1\|WP_013860044.1\|2604503_2605667_-\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340831
NC_016023.1\|WP_014097634.1\|2615232_2616156_-\|1,4-dihydroxy-2-naphthoate-polyprenyltransferase	unknown	unknown	gnl\|CDD\|235695
NC_016023.1\|WP_013860045.1\|2604000_2604180_+\|hypothetical-protein	unknown	unknown	unknown
NC_016023.1\|WP_014097629.1\|2600767_2601835_+\|DUF1646-family-protein	unknown	unknown	gnl\|CDD\|285138
NC_016023.1\|WP_014097631.1\|2602752_2603658_+\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|223769
NC_016023.1\|WP_187287754.1\|2595475_2595802_+\|metal-sensitive-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197387
NC_016023.1\|WP_014097637.1\|2619496_2620300_+\|2-succinyl-6-hydroxy-2,-4-cyclohexadiene-1-carboxylate-synthase	unknown	unknown	gnl\|CDD\|274729
NC_016023.1\|WP_100183710.1\|2625848_2625977_-\|DUF4021-domain-containing-protein	unknown	unknown	unknown
NC_016023.1\|WP_014097630.1\|2601972_2602662_-\|MgtC/SapB-family-protein	unknown	unknown	gnl\|CDD\|224204
NC_016023.1\|WP_014097640.1\|2623186_2624290_+\|o-succinylbenzoate-synthase	unknown	unknown	gnl\|CDD\|239433
NC_016023.1\|WP_014097626.1\|2595817_2596024_+\|copper-chaperone-CopZ	unknown	unknown	gnl\|CDD\|188014
NC_016023.1\|WP_014097627.1\|2596117_2598532_+\|copper-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319783
NC_016023.1\|WP_014097639.1\|2621735_2623190_+\|o-succinylbenzoate--CoA-ligase	unknown	unknown	gnl\|CDD\|235146
NC_016023.1\|WP_017551861.1\|2616421_2617753_+\|isochorismate-synthase	unknown	unknown	gnl\|CDD\|224091
NC_016023.1\|WP_014097641.1\|2624618_2624777_-\|DUF1540-domain-containing-protein	unknown	unknown	gnl\|CDD\|377869
NC_016023.1\|WP_014097636.1\|2617754_2619500_+\|2-succinyl-5-enolpyruvyl-6-hydroxy-3--cyclohexene-1-carboxylic-acid-synthase	unknown	unknown	gnl\|CDD\|236020

Protein	Function_ID	Function_description	E-value
NC_016023.1\|WP_014097623.1\|2593197_2593608_+\|Lrp/AsnC-family-transcriptional-regulator	gnl\|CDD\|214628	smart00344, HTH_ASNC, helix_turn_helix ASNC type. AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli).	1.56378e-35
NC_016023.1\|WP_014097633.1\|2606562_2606769_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224393	COG1476, COG1476, Predicted transcriptional regulators [Transcription].	1.09584e-26
NC_016023.1\|WP_014097638.1\|2620339_2621158_+\|1,4-dihydroxy-2-naphthoyl-CoA-synthase	gnl\|CDD\|180958	PRK07396, PRK07396, dihydroxynaphthoic acid synthetase; Validated.	0
NC_016023.1\|WP_014097642.1\|2624838_2625729_-\|zinc-ABC-transporter-substrate-binding-protein	gnl\|CDD\|238499	cd01017, AdcA, Metal binding protein AdcA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AdcA proteins belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. They are comprised of two globular subdomains connected by a long alpha helix and they bind their ligand in the cleft between these domains. In addition, many of these proteins have a low complexity region containing metal binding histidine-rich motif (repetitive HDH sequence).	7.81345e-97
NC_016023.1\|WP_013860044.1\|2604503_2605667_-\|glycosyltransferase-family-4-protein	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	2.06596e-14
NC_016023.1\|WP_014097634.1\|2615232_2616156_-\|1,4-dihydroxy-2-naphthoate-polyprenyltransferase	gnl\|CDD\|235695	PRK06080, PRK06080, 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated.	1.82517e-126
NC_016023.1\|WP_017551861.1\|2616421_2617753_+\|isochorismate-synthase	gnl\|CDD\|224091	COG1169, MenF, Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	3.78677e-133
NC_016023.1\|WP_014097631.1\|2602752_2603658_+\|DMT-family-transporter	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	1.80023e-12
NC_016023.1\|WP_187287754.1\|2595475_2595802_+\|metal-sensitive-transcriptional-regulator	gnl\|CDD\|197387	cd10152, SaCsoR-like_DUF156, Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156. This domain family includes Staphylococcus aureus CsoR (SaCsoR). SaCsoR is Cu(I)-inducible, and regulates the expression of genes involved in copper homeostasis; it represses a genetically unlinked copA-copZ operon. copA encodes a copper efflux P-type ATPase, and copZ, a copper chaperone. This family belongs to a larger superfamily that contains various transcriptional regulators that respond to different stressors such as Cu(I), Ni(I), sulfite, and formaldehyde, and includes Mycobacterium tuberculosis CsoR (MtCsoR), Bacillus subtilis CsoR, and Thermus thermophilus CsoR. The latter three proteins do not belong to this family. CsoRs form homotetramers (dimer of dimers). In MtCsoR, within each dimer, two Cys residues on opposite subunits, along with a His residue, bind the Cu(I) ion (forming a triagonal S2N coordination complex, C-H-C). These residues are conserved in the majority of members of this superfamily, including this family, and a conserved Tyr and a Glu residue that facilitate allosteric regulation of DNA binding for CsoRs are also well conserved.	3.39737e-38
NC_016023.1\|WP_014097637.1\|2619496_2620300_+\|2-succinyl-6-hydroxy-2,-4-cyclohexadiene-1-carboxylate-synthase	gnl\|CDD\|274729	TIGR03695, menH_SHCHC, 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase. This protein catalyzes the formation of SHCHC, or (1 R,6 R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate, by elmination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Note that SHCHC synthase activity previously was attributed to MenD, which in fact is SEPHCHC synthase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone].	2.19371e-120
NC_016023.1\|WP_014097639.1\|2621735_2623190_+\|o-succinylbenzoate--CoA-ligase	gnl\|CDD\|235146	PRK03640, PRK03640, o-succinylbenzoate--CoA ligase.	0
NC_016023.1\|WP_014097630.1\|2601972_2602662_-\|MgtC/SapB-family-protein	gnl\|CDD\|224204	COG1285, SapB, Uncharacterized membrane protein [Function unknown].	2.65313e-51
NC_016023.1\|WP_014097640.1\|2623186_2624290_+\|o-succinylbenzoate-synthase	gnl\|CDD\|239433	cd03317, NAAAR, N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building blocks for antibiotics, herbicides, and drugs. NAAAR is a member of the enolase superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion.	0
NC_016023.1\|WP_014097626.1\|2595817_2596024_+\|copper-chaperone-CopZ	gnl\|CDD\|188014	TIGR00003, COP-associated_protein, copper ion binding protein. This model describes an apparently copper-specific subfamily of the metal-binding domain HMA (pfam00403). Closely related sequences outside this model include mercury resistance proteins and repeated domains of eukaryotic eukaryotic copper transport proteins. Members of this family are strictly prokaryotic. The model identifies both small proteins consisting of just this domain and N-terminal regions of cation (probably copper) transporting ATPases. [Transport and binding proteins, Cations and iron carrying compounds].	4.71185e-19
NC_016023.1\|WP_014097627.1\|2596117_2598532_+\|copper-translocating-P-type-ATPase	gnl\|CDD\|319783	cd02094, P-type_ATPase_Cu-like, P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B. The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NC_016023.1\|WP_014097629.1\|2600767_2601835_+\|DUF1646-family-protein	gnl\|CDD\|285138	pfam07854, DUF1646, Protein of unknown function (DUF1646). Some of the members of this family are hypothetical bacterial and archaeal proteins, but others are annotated as being cation transporters expressed by the archaebacterium Methanosarcina mazei.	4.16648e-105
NC_016023.1\|WP_014097641.1\|2624618_2624777_-\|DUF1540-domain-containing-protein	gnl\|CDD\|377869	pfam07561, DUF1540, Domain of Unknown Function (DUF1540). This family has four conserved cysteines, which is suggestive of a metal binding function.	8.61231e-10
NC_016023.1\|WP_014097636.1\|2617754_2619500_+\|2-succinyl-5-enolpyruvyl-6-hydroxy-3--cyclohexene-1-carboxylic-acid-synthase	gnl\|CDD\|236020	PRK07449, PRK07449, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Validated.	0

>NC_016023.1|WP_014097633.1|2606562_2606769_-|helix-turn-helix-transcriptional-regulator
MKNNLPEIRSEFGYSQEKLAKELNVSRQTIISIEKGKYNPSLPLALKIAKIFNMKVEDIFTLNEKEEL
>NC_016023.1|WP_013860044.1|2604503_2605667_-|glycosyltransferase-family-4-protein
MKPIATPFPPVSMGDIHVYDDIIQYFNFKQVKQALPHRPKSITFVTTGIIPYDGGQTTMLHLGTELSKLGFQVYYLSYFSQPRKAMEINAEFNYAGYQGTCLDVSALKTHQSDIWIGTLWESVYVFKDKPGYKMYFVQDYEPYFYPFGDRYYLAKKTYELGLHMVSLGPWCAEMIEKECRVQSPLDVIRFPVDMEQYPFHPRNFLDYKKKKEFRIAVYTKWDSPRRAPITIQIVLNNFLKLCQKHGYQLDIVYFGTDQSAQFINGKNLGQLTKKELHELYLKSDFGIAPSMTNFSLVPYEMMSSGLPVIDFYEGTGRSFMPENCALFCHLDEQSLFQTFQNAISHPGHIAETVKNAQAHLNTVTWKETIKDFINVINTIQSKNRIVS
>NC_016023.1|WP_013860045.1|2604000_2604180_+|hypothetical-protein
MNKKNQIFLAILLILSVAGFIANMIVGPAPRWIKAYNLLVVLAWGVWIFRTGKEKGRYW
>NC_016023.1|WP_014097631.1|2602752_2603658_+|DMT-family-transporter
MNPYIALIAGVLAVTSSAILVKYSTADAGVIAFYRLFFTTIIMMPIFLAARKKAKMRMLKKDVFFSILSGALLAFHFILWFKSLNLTSVASSTVLVTLQPVFTFAGSYFIFRESLSLKAIVCAAFSIFGSILISWGDFFISGKALYGDVLALISCLFVTAYMMIGQYVRQRSDVVSYTFIVYLASTVVLFFYVLFAGEAFYPYSARNWICFLLLAVLPTLAGHSVFSWVVKWISASVVSVAILFEPVGAAILAYLLFGEKISWFQAVGGIIILLSIAYFLAQDHAEHRRAVRLNEKSEPAR
>NC_016023.1|WP_014097630.1|2601972_2602662_-|MgtC/SapB-family-protein
MVFGDLEILYKLGITAVLGLIIGLERELKRKPLGLKTSLVISIISCILTIVSIQSAYLFNHAHSVQITMDPLRLAAQIVSGIGFLGAGVILKKDNDTITGLTTAAMIWGASGIGIAVGAGFYMEAIAGVVLIIISVEIIPYLMGKAAQSKLRNKDLIIKVIVCNRDAIPSVLDAIEKQHITIENIRIKDLKDQTHLVDLKARASYKHTTVDVYRHISGMDEVAAAEVES
>NC_016023.1|WP_014097629.1|2600767_2601835_+|DUF1646-family-protein
MVMGLSVILLLVLCLPFTKIVERNLEAFLFVMGVAACIVSRSFSWHLVQEALLHPLNITIAVLAMGLLFRWFEKPIEKGISRISHAMPFRLFIALFVIILGLLSSVITAIVAAIVLVTIIRFLRLDRKTEVRLVVLACFAIGLGAVLTPIGEPLSTIVVSKLDADFFYLLRLTGTSVIPAVILFGVLAALIVKPGQYTSAMETAAGKEPSIASKEDEGLKAEPASESYKEIVIRSFKIYLFVMALTLLGAGFEPFIEAYLLDLNPLVLYWINMVSAVLDNATLAAAEISPAMGDKAIQDILMGLLISGGMLVPGNIPNIIAAGKLKISSIEYARFAFPLGLAAMVVYFAIILFLV
>NC_016023.1|WP_014097627.1|2596117_2598532_+|copper-translocating-P-type-ATPase
MAASLQEKKDASVTLGITGMTCAACANRIEKNLSKVEGVKKVSVNLATEKAAIQYDTKQATVENLIEKVEKTGYGVLEEKAQLNIIGMTCAACANRVERALKKTPGVVSAAVNLATETASVTYLPGQASAEQMIAAVKKAGYDAKVKGELDPDYEKKMREKAYKKQKIKFAVGAVISVFFLLQMISDIAMHYGGSFSFHMNPWLQLLLATIVQIFVGGHYYRDAYHAIRGGSANMAVLVVLGTSTAYLYSLVLTILGSGRMLYFEASAIVMTLIVLGKLMETRAKGQTSEAMKKLMGLQAKTARVNRGGKEIEVPVEEVVPGDILLVRAGEKIPVDGVITEGASSVDESMLTGESMPVSKKAGDAVIGATLNKTGSFRFKATKVGKDTALSQIIKLVEEAQGSKAPIQHLADQISGIFVPIVILIALVTFAVTYFAAGFTPAMVSMVAVLVIACPCALGLATPTAVMVGTGLGAENGVLIKSAEHLQSAHRITTVVLDKTGTITKGEPEVTDLIPYGGFSEDELLALSAAAEKGSEHPLGAAIVKKAAEKGLQLPNVTEFEAVPGRGIRVKIEEREVLIGNKKMMQDAHIRIDDVISQMEKLEEDGKTAMLIAMDGALSGLIAVADTVKETSAKAIRMLKEMGIETVMMTGDNRRTAEAIARQVGVDRVLAEVLPEDKSKEVEKLKRAGNITAMVGDGINDAPALAAADVGIAIGTGTDVAMEAADITLMRGDLMGIVNTIRLSKATMRKIRQNLFWAFAYNVVLIPVAAFGLLNPILAGAAMAFSSVSVVGNTLFLRKWQPVS
>NC_016023.1|WP_014097626.1|2595817_2596024_+|copper-chaperone-CopZ
MEKVTLNVQGMSCEHCVKAVKGSVGELSGVKNVDVHLAEGKVDVEFDPNKVTLDKVKEAIEDQGYEVA
>NC_016023.1|WP_187287754.1|2595475_2595802_+|metal-sensitive-transcriptional-regulator
MDAARDEASVCPAHSERKSHHSEKVKKNLVSRLNRIEGQVRGVKGLIEKDTYCDDVITQIAAIQSALNSVSKILLEGHLKNCVLERIQEGDLDVLDEFLVTIQKTMRK
>NC_016023.1|WP_014097623.1|2593197_2593608_+|Lrp/AsnC-family-transcriptional-regulator
MDFIDEQIIHELKEDSRLSMSELSRRIHLSAPAVRERVRQLEEQDIIKRYTIELNQKKLGYPIEAIIEATIKNNRYDDFKKQICQYSNVDFCYRIAGEACFMLKARFHSFEDAEQFIDKLQLFAHSKTNFIFSKVI
>NC_016023.1|WP_014097634.1|2615232_2616156_-|1,4-dihydroxy-2-naphthoate-polyprenyltransferase
MNAQSSPSIGPDKGWRIWWQLTRPHTLTAGFVPVILGTVLALGIARINLLLFAAMLVATLLIQAATNMFNEYYDYKRGLDTEHSVGIGGAIVRNGIKPKTVLHLAFAFFGAAMLIGVYICSQSSWWIAVIGTVCMLVAYLYTAGPFPISSTPLGELISGFFMGVIIILISFFIQTKTITWPIVFISIPIMILIGAIMLSNNIRDLDGDKANGRKTIAILLGRKGAILLLAAMFALSYLWMAGLVLFGVVTPWVLLVFVSTPKPVRAIKGFIGKSEPLQMLPAMKATAQTNTIFGVLLSISFLIDHFI
>NC_016023.1|WP_017551861.1|2616421_2617753_+|isochorismate-synthase
MKEKTAPALKLVSKVIKCRTAPDPLRLFTAGAARFYGSRFFWQDADRETVFVGFGRVWSCTVTASDGFAQMEDEWRNLKGAGEVYSDTGETGTGPVLFGGFAFDGTVAKQEWKTFGQGIFRVPQILFTFKKDAVFLTVNGCGGTESVQEAEETARSLLNGSTAFPALPLLKAVKEIGSDEWKKSVATAVEFIREGRMDKVVLARKLELAFDGVASPDAVLAALSAQQHDSYLFVLEEGSESFIGASPERLVKKTGRHILSTCLAGSIKRGRNEAEDLELGKALLSDQKNLSEHGFVVSMIRQVLEPFCNGLNVPDAPVLMRMRDIQHLYTPVTGTVKDKDTTLFQLVKALHPTPALGGIPRQPAMEAIRLLEKMDRGLYGAPIGWVDYRGSGEFCVGIRSGLLKEDHASLYAGCGVVKESEPEEEYKETSVKFTPMLRALGGK
>NC_016023.1|WP_014097636.1|2617754_2619500_+|2-succinyl-5-enolpyruvyl-6-hydroxy-3--cyclohexene-1-carboxylic-acid-synthase
MEHQEIMTTYLAAFIRQLSAMGIRYAVVSPGSRSTPIAMLLAEHPDFKIYMDIDERSAAFFALGLAKEKRKPVVLLCTSGTAAANYYPAVAEANISRVPLIVLTADRPHELRNVGAPQAIDQIRLYGTHVKWFEEMPLPEAGEEVLQFVRQTAARAVVTALQQPAGPVHLNFPLREPLVPVLKPSPFAGEVPVPAIENFSGTLQLSEETVEVVAKEIREKNRGLIICGPIDIPGFAEAVVALSEKTGYPVLADPLSQLRSGRHGKERIIENYDSLLKDPKWADRLAPDVVIRFGAMPVSKPLTLLLKKVKTAAHYIVDGGNGWRDPVKRGTTVVYSDEIDFCKKLSNIIVMNPVSEWFTMWEKLNQQARQIVTASLEAEETFDEGKTVTELAAALPDGSTLFVGNSMPIRDVDTFFQATDKKIRILANRGANGIDGVVSSAAGVSAGCGKAFLLIGDLSFFHDLNGLLMTKMHKLNLCVILINNNGGGIFSFLPQADEPEKFEQLFGTPTDLAFEYAVKMYGGSYIQPQNWDQFRAALSEYKGGLQVIEVRTNRAKNVETHRKIWSQVSREMERYFQGEQQ
>NC_016023.1|WP_014097637.1|2619496_2620300_+|2-succinyl-6-hydroxy-2,-4-cyclohexadiene-1-carboxylate-synthase
MRINGLEYHVETAGDGEPLLLLHGFTGNGNTWDDTVALLRDEFRCIVVDIIGHGKTEKPDDSDRYDITKAAADLRAVLLALGIRRASILGYSMGGRLALTFAVQYPQMVDKLVLESASPGLKTEAERLARRERDEQLAERILTGGMEAFVSHWENLPLFASQKQLPAEVRGKIRKQRLENDPAGLANSLRGMGTGAQPSWWGRLSELHFPVLLAAGEWDAKFCRIAGEMEERLPHAKKIIFSHAGHAIHVEDPKKFGTMVKGFLKNC
>NC_016023.1|WP_014097638.1|2620339_2621158_+|1,4-dihydroxy-2-naphthoyl-CoA-synthase
MAVEWKTEHEYEDILYESYNGIAKITINRPHVRNAFRPETVTEMYDAFSRARDDANIGVIILTGMGEKAFCSGGDQKVRGNGGYVGSDNIPRLNVLDLQHLIRVIPKPVIAMVAGYAIGGGNVLQVVCDLTIAADNAIFGQTGPKVGSFDGGYGAGYLARIVGHKKAREIWYLCRQYNAQEALEMGLVNAVVPYEKLEEETIKWAEEILEKSPMAIRFLKAAFNADTDGLAGLQQFAGDATLLYYTTDEAKEGRDAFKEKRKPDFGQFPRFP
>NC_016023.1|WP_014097639.1|2621735_2623190_+|o-succinylbenzoate--CoA-ligase
MLPNFLKQRAYLTPNRIALISQGTSLTFAGLYEKAKETARKLSGCGMQAEDTAAVLLNSRAETVVILHALQQLRVRTLFLNHRLTPAEMQYQLTDSGAKWLITEKSFREKAEVLNETATVIQSEALDGLPAAGYEERVEFGLEDVCSIMYTSGTTGKPKGVLQTYGNHWWSAAGSALNLGVREDDTWLCAVPLFHISGFSILMRSVFYGMTVYLMEKFDEKETAKLLKSGRITTMSVVTNMLQRLLRELGQERLHPNFRCLLLGGGPAPRPLLEACAEKNIPVFQSYGMTETASQTVTLAPEDSLRKIGSAGKPLFPAQIRIVSDGKVCGPFEHGEIAVKGPNVTIGYLNRPDANQKSFRDGWFFTGDIGYLDDEGFLYVLDRRSDLIISGGENIYPAEIEEVLLAHPDILEAGVIGVEDEKWGQVPAAFIVTKRAVQERELQAFCETRLAKFKIPKKVYAVPALPRNASNKLVRRKLLELLPS
>NC_016023.1|WP_014097640.1|2623186_2624290_+|o-succinylbenzoate-synthase
MIGIEKVTLSVIKMPLKSPFENALEKVTEREAILLEVTDNDGVTGFGEAVAFSTPWYTEETVQTCFHMLKDVLVPLLREKPVAHPKEVSGRFQSVRRNHMAKAAIETAIWDLYAKKKQKPLWQLIGGARDYVDAGVAVGSHDTAEALRQIAAFVDEGYKRVKVKIKPGHDEAFIREIRHAFPDLALMADANSAYTLADAPDLKRLDRYGLLMIEQPLAADDIVEHAALQKQLETPVCLDESIVTYHDAESALRLGSFRVLNIKIGRVGGLYPAIRLHDLCASRGIPVWCGGMIEFGVSRAFNLALASLPGFTIPGDISSSSRFWEKDIIEPEITVENGQIRLPDRPGTGFEIDRAYVEKTRTYTETI
>NC_016023.1|WP_014097641.1|2624618_2624777_-|DUF1540-domain-containing-protein
MAKDVLCEVRNCVFWEEGNLCSAEEIYIVSHTGTQAENQRETDCKTFESMFS
>NC_016023.1|WP_014097642.1|2624838_2625729_-|zinc-ABC-transporter-substrate-binding-protein
MKKLFPVLLAFTMLFVTACANKQESKQDHKISVYTTVYPLEYVTQQIGGKYVSVKTIYPPGTDEHTYEPSQKDILKLADSDFFFYIGLGLEGFANKAKQVLEGQNVKMMALGDRLPVPDKTSTKADPHVWLDPIYVKQMAGMITTQLSKKMPKQKTYFKKNYAQLAKKLDQVNAAYKQAVEKSDNKELVVSHAAYGYWVKRYGIKQIPIAGLSTSDEPSQKQLENIIQKVKQDHISYIVFEKNVPSKIAKVVQQETNTKAVYIHHLGVRTNAEIKAHKDYFTLMDDNLKALEKALQ
>NC_016023.1|WP_100183710.1|2625848_2625977_-|DUF4021-domain-containing-protein
MFFMEEKKEQQKKSGDFGADPDEQAINGDYGMLETEEEDKKD

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Crispr_ID: NC_016023_17

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016023_17

2631865-2631945

Orphan

Consensus_repeat	Method
CCATTTGCGAATTGGATCTTGCAAAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_016023_17

>merge|NC_016023|17|2631865-2631945|CRISPRCasFinder
CCATTTGCGAATTGGATCTTGCAAAGCGAACGAACGGGTTTTGGGAAAAACGCCCCCATTTGCGAATTGGATCTCGCAAAG

>NC_016023|17|16|2631865-2631945|CRISPRCasFinder
CCATTTGCGAATTGGATCTTGCAAAG	CGAACGAACGGGTTTTGGGAAAAACGCCC
CCATTTGCGAATTGGATCTCGCAAAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_016023.1\|WP_014097652.1\|2635890_2636280_+\|DNA-mismatch-repair-protein-MutT	unknown	unknown	gnl\|CDD\|240040
NC_016023.1\|WP_100183710.1\|2625848_2625977_-\|DUF4021-domain-containing-protein	unknown	unknown	unknown
NC_016023.1\|WP_014097644.1\|2626421_2626871_+\|DNA-starvation/stationary-phase-protection-protein	unknown	unknown	gnl\|CDD\|223854
NC_016023.1\|WP_014097654.1\|2638484_2639696_+\|methionine-adenosyltransferase	unknown	unknown	gnl\|CDD\|235374
NC_016023.1\|WP_014097649.1\|2632052_2633588_-\|gluconokinase	unknown	unknown	gnl\|CDD\|130381
NC_016023.1\|WP_014097648.1\|2630063_2631071_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|223787
NC_016023.1\|WP_014097658.1\|2643686_2644781_+\|tetraprenyl-beta-curcumene-synthase-family-protein	unknown	unknown	gnl\|CDD\|378492
NC_016023.1\|WP_014097655.1\|2639926_2641825_+\|asparagine-synthase-(glutamine-hydrolyzing)	unknown	unknown	gnl\|CDD\|223444
NC_016023.1\|WP_014097646.1\|2628460_2629267_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223673
NC_016023.1\|WP_014097657.1\|2642869_2643676_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|225176
NC_016023.1\|WP_014097645.1\|2627360_2627822_+\|nucleoside-triphosphatase-YtkD	unknown	unknown	gnl\|CDD\|131752
NC_016023.1\|WP_014097651.1\|2634354_2635407_+\|DUF2584-family-protein	unknown	unknown	gnl\|CDD\|224423
NC_016023.1\|WP_014097641.1\|2624618_2624777_-\|DUF1540-domain-containing-protein	unknown	unknown	gnl\|CDD\|377869
NC_016023.1\|WP_014097650.1\|2633805_2634348_+\|flavodoxin-family-protein	unknown	unknown	gnl\|CDD\|223728
NC_016023.1\|WP_014097642.1\|2624838_2625729_-\|zinc-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238499
NC_016023.1\|WP_017550244.1\|2636430_2638020_-\|phosphoenolpyruvate-carboxykinase-(ATP)	unknown	unknown	gnl\|CDD\|376517
NC_016023.1\|WP_013860030.1\|2626943_2627192_-\|hypothetical-protein	unknown	unknown	unknown
NC_016023.1\|WP_014097656.1\|2642195_2642711_-\|gamma-carbonic-anhydrase-family-protein	unknown	unknown	gnl\|CDD\|100051
NC_016023.1\|WP_014097647.1\|2629253_2630024_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213260
NC_016023.1\|WP_013860032.1\|2626068_2626305_-\|membrane-protein-insertion-efficiency-factor-YidD	unknown	unknown	gnl\|CDD\|178815

Protein	Function_ID	Function_description	E-value
NC_016023.1\|WP_014097652.1\|2635890_2636280_+\|DNA-mismatch-repair-protein-MutT	gnl\|CDD\|240040	cd04684, Nudix_Hydrolase_25, Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	1.40989e-06
NC_016023.1\|WP_014097641.1\|2624618_2624777_-\|DUF1540-domain-containing-protein	gnl\|CDD\|377869	pfam07561, DUF1540, Domain of Unknown Function (DUF1540). This family has four conserved cysteines, which is suggestive of a metal binding function.	8.61231e-10
NC_016023.1\|WP_014097644.1\|2626421_2626871_+\|DNA-starvation/stationary-phase-protection-protein	gnl\|CDD\|223854	COG0783, Dps, DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism].	1.27399e-59
NC_016023.1\|WP_014097654.1\|2638484_2639696_+\|methionine-adenosyltransferase	gnl\|CDD\|235374	PRK05250, PRK05250, S-adenosylmethionine synthetase; Validated.	0
NC_016023.1\|WP_014097649.1\|2632052_2633588_-\|gluconokinase	gnl\|CDD\|130381	TIGR01314, gntK_FGGY, gluconate kinase, FGGY type. Gluconate is derived from glucose in two steps. This model describes one form of gluconate kinase, belonging to the FGGY family of carbohydrate kinases. Gluconate kinase phosphoryates gluconate for entry into the Entner-Douderoff pathway. [Energy metabolism, Sugars].	0
NC_016023.1\|WP_014097648.1\|2630063_2631071_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|223787	COG0715, TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism].	1.74695e-44
NC_016023.1\|WP_014097658.1\|2643686_2644781_+\|tetraprenyl-beta-curcumene-synthase-family-protein	gnl\|CDD\|378492	pfam10776, DUF2600, Protein of unknown function (DUF2600). This is a bacterial family of proteins. Some members in the family are annotated as YtpB however currently no function is known.	0
NC_016023.1\|WP_014097655.1\|2639926_2641825_+\|asparagine-synthase-(glutamine-hydrolyzing)	gnl\|CDD\|223444	COG0367, AsnB, Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism].	0
NC_016023.1\|WP_014097646.1\|2628460_2629267_-\|ABC-transporter-permease	gnl\|CDD\|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	5.22184e-66
NC_016023.1\|WP_014097657.1\|2642869_2643676_+\|alpha/beta-hydrolase	gnl\|CDD\|225176	COG2267, PldB, Lysophospholipase [Lipid metabolism].	3.67526e-69
NC_016023.1\|WP_014097645.1\|2627360_2627822_+\|nucleoside-triphosphatase-YtkD	gnl\|CDD\|131752	TIGR02705, conserved_hypothetical_protein, nucleoside triphosphatase YtkD. The functional assignment to the proteins of this family is contentious, with papers disagreeing in both interpretation and enzyme assay results. This protein belongs to the nudix family and shares some sequence identity with E. coli MutT but appears not to be functionally interchangeable with it. [DNA metabolism, DNA replication, recombination, and repair].	1.41101e-54
NC_016023.1\|WP_014097651.1\|2634354_2635407_+\|DUF2584-family-protein	gnl\|CDD\|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	1.7245e-50
NC_016023.1\|WP_014097650.1\|2633805_2634348_+\|flavodoxin-family-protein	gnl\|CDD\|223728	COG0655, WrbA, Multimeric flavodoxin WrbA [General function prediction only].	2.28697e-28
NC_016023.1\|WP_014097642.1\|2624838_2625729_-\|zinc-ABC-transporter-substrate-binding-protein	gnl\|CDD\|238499	cd01017, AdcA, Metal binding protein AdcA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AdcA proteins belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. They are comprised of two globular subdomains connected by a long alpha helix and they bind their ligand in the cleft between these domains. In addition, many of these proteins have a low complexity region containing metal binding histidine-rich motif (repetitive HDH sequence).	7.81345e-97
NC_016023.1\|WP_017550244.1\|2636430_2638020_-\|phosphoenolpyruvate-carboxykinase-(ATP)	gnl\|CDD\|376517	pfam01293, PEPCK_ATP, Phosphoenolpyruvate carboxykinase.	0
NC_016023.1\|WP_014097656.1\|2642195_2642711_-\|gamma-carbonic-anhydrase-family-protein	gnl\|CDD\|100051	cd04645, LbH_gamma_CA_like, Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Gamma CAs are trimeric enzymes with left-handed parallel beta helix (LbH) structural domain.	2.55616e-77
NC_016023.1\|WP_014097647.1\|2629253_2630024_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213260	cd03293, ABC_NrtD_SsuB_transporters, ATP-binding cassette domain of the nitrate and sulfonate transporters. NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	5.17567e-113
NC_016023.1\|WP_013860032.1\|2626068_2626305_-\|membrane-protein-insertion-efficiency-factor-YidD	gnl\|CDD\|178815	PRK00041, PRK00041, hypothetical protein; Validated.	2.01477e-41

>NC_016023.1|WP_014097648.1|2630063_2631071_-|ABC-transporter-substrate-binding-protein
MKKWLKSGCTLLLAALLAFSLSACGSIGSKKKALQKVRVAEVTRSVFYTPLYVALEKGYFKEEGLDIKLTTTWGGDKTMTALLSGGTDIALVGSETSIYVYKQKAADPVINFAQLTATDGTFLVSRKKIDHFSWDMLKGTTFLGQRKGGMPQMVGEFVLKKHGIDPHKDTKLIQNIDFANVANAYASGTGDFVQLFEPTASTMEKEGKGYIVASFGKESGEVPYTTFMAKQSYLKEHEKTAVKFVRALLKAGKWVQKTDAETVAKTVQPYFKDTKTDMLASSIERYRSQGSFSSDMILTKSGWNTIQDIMKEAGELDHTVPYDKLVNASIVKKAK
>NC_016023.1|WP_014097647.1|2629253_2630024_-|ABC-transporter-ATP-binding-protein
MHFLTVQNVNHTYFTAKQATKALENISFQMEEGEFVSLLGPSGCGKTTLLSILAGLLQPTAGIVQIDGKLPGSRQSSIGYMLQQDYLFPWKTIEENIMIGLKLEKRLNPESRKHALGLLQTIGLAGTEKQYPRQLSGGMRQRAALVRTLAVDPKILLLDEPFSALDFQTKLKLEDLVFDTLKQFHKTAVLVTHDIGEAIAMSDRILLLASKPGRLYKIFDVPTELRRLRPFEARSQKIYSELFNDIWKELESLENS
>NC_016023.1|WP_014097646.1|2628460_2629267_-|ABC-transporter-permease
MKTAENTALWHEDYLAAMRKEKRRVRFFQLFILIVFFCLWEVASRLHWIDPLIFSSPSKVWALLVAKLEDGSLYVHLGITVFETVMGFILGTVLGAALAAVLWWSPFLSKILDPYLVVLNAMPKVALGPILIVSMGPGFSSIVAMGVIISVIVTTIVIYTAFRDVDPNYTKVLHSFGASRLQVFREAIFPASIPVIISTLKVNVGLAWVGVIVGEYLVSSKGLGYMIIYGFQVFNFTLVMLSMILIAIVATIMYQLVGWLEKKLVKDR
>NC_016023.1|WP_014097645.1|2627360_2627822_+|nucleoside-triphosphatase-YtkD
MYRFTDLNGNPVTFIFEKNAFPIEPQHVLVLARYRGNWLLTRHPKRGLEFPGGKREAGETVREAAERELYEETGGIPENLQYIGEYCVDDQVRGPFVKAVFYADIGRLETKHDYLETDGPVLVEGDLVGKLQSSSFSFLMKDGVVETALRHVE
>NC_016023.1|WP_013860030.1|2626943_2627192_-|hypothetical-protein
MRLVDELFELYRDRLTGDEEDLDAISAAVVENYNRKDLLGIVREMSTAELEHFIGLYILETLKDKFSDYAGFDAYPTTKYLQ
>NC_016023.1|WP_014097644.1|2626421_2626871_+|DNA-starvation/stationary-phase-protection-protein
MAENEQLMEILNKQVANWTVLYTKLHNYHWYVKGPNFLSLHAKFEELYNLANDYLDELAERLLALNGNPVATLKGSLELSSVQEASGNESTEEMVQGTANDFAMIAKELEEAIGLANRIGDDATADMFINIQETLDKNIWMLNAFLGRR
>NC_016023.1|WP_013860032.1|2626068_2626305_-|membrane-protein-insertion-efficiency-factor-YidD
MLKFIFIKLIRFYQLAISPLFPPSCRFQPTCSNYGLEAVKRFGALRGGYLAIRRILKCHPFHAGGYDPVPDQWPVKKH
>NC_016023.1|WP_100183710.1|2625848_2625977_-|DUF4021-domain-containing-protein
MFFMEEKKEQQKKSGDFGADPDEQAINGDYGMLETEEEDKKD
>NC_016023.1|WP_014097642.1|2624838_2625729_-|zinc-ABC-transporter-substrate-binding-protein
MKKLFPVLLAFTMLFVTACANKQESKQDHKISVYTTVYPLEYVTQQIGGKYVSVKTIYPPGTDEHTYEPSQKDILKLADSDFFFYIGLGLEGFANKAKQVLEGQNVKMMALGDRLPVPDKTSTKADPHVWLDPIYVKQMAGMITTQLSKKMPKQKTYFKKNYAQLAKKLDQVNAAYKQAVEKSDNKELVVSHAAYGYWVKRYGIKQIPIAGLSTSDEPSQKQLENIIQKVKQDHISYIVFEKNVPSKIAKVVQQETNTKAVYIHHLGVRTNAEIKAHKDYFTLMDDNLKALEKALQ
>NC_016023.1|WP_014097641.1|2624618_2624777_-|DUF1540-domain-containing-protein
MAKDVLCEVRNCVFWEEGNLCSAEEIYIVSHTGTQAENQRETDCKTFESMFS
>NC_016023.1|WP_014097649.1|2632052_2633588_-|gluconokinase
MTYYLGVDIGTTTTKSVLFGEKGKVISMHHAGYPLYSPSPQVAEQNPDEIFRAVIDSMKTAIVKSDIDPSEIKLVSFSSAMHSLIAVDKDGKPLTNCITWADARAAKWAKKIKDEWHGQDIYRRTGTPIHPMSPLSKITWLRHEEQELFKKTFKFIGIKEYIFYRFFGQYVVDYSLASATGLFNLHDLDWDKEALHVAGITADKLSKPVPTTFSLTGLAPEYAVETGIPQDTPFVAGASDGVLSNLGVNAIDPGVVAITIGTSGAIRTVTDKPVTDPKGRIFCYALTENHWVVGGPVNNGGMTFRWVRDELAAAEVETAKRLGIDPYEVLTKIAARVAPGSDGLIFHPYLAGERAPIWNADARGSFFGLGLHHKREHMVRAVLEGVIYNLYTVMLALQEMIGIPKKIQATGGFARSDLWRQMLADIFNQEVVVPESFESSCLGAIVLGMYALDEIDDFSVVSDWIGATHTHRPIPENTAVYEEILPIYIRISRLLEGEYTNIAAFQRKWVK
>NC_016023.1|WP_014097650.1|2633805_2634348_+|flavodoxin-family-protein
MTIAVIYGSSRPRGNTEMLTERAVEGMHVERFYLKDAHILPIEDKRHTDSGFSKVEDDYSILIQHIFMCDTIIFATPIYWYGMSGLMKNFIDRWSQTLRDPQFPDFKKRMAEKKIYVIAVGGDMPRVKGLPLIQQFAYIFDFLGMRFDGYILGEGNKPGDIVQDKEAIFAADQLNEALKR
>NC_016023.1|WP_014097651.1|2634354_2635407_+|DUF2584-family-protein
MKTVIEKQLFPSPNPHVRMYLVTYWSDGLKVKGLLAEPDDGRVYDGFLYLRGGIKSVGMVRPARIGEFASEGFIVFAPFYRGNWGGEGDEDFGGDDMHDAYFGFDVLMEHERVSGRVHVFGFSRGGIMALGTAEARPAASIVTWGGVSDVALCYAERVDLRKMMKRVIGGTPEKYPERYRVRTPLYKLGQIGCPVLVIHGEKDQNVSVEHAIRLEHGLKQLGKSVETWYFPELGHHFPPPVNRRIVHAASVWMKRHSAHDTIEATTEVSRMGMPMELDTMLVTNGKEERIEQNLFLLKQPGYCVYPLDTPVEIRKKKEHGPSGSAVIRKLEWENNTTIVHYELVSLNTPN
>NC_016023.1|WP_014097652.1|2635890_2636280_+|DNA-mismatch-repair-protein-MutT
METDYKKACGAYAVIFDAKKEKVGVVPSGSGYRLPGGEISRGESELACLMRTVGAELEIAGFLGKAAQETGARSMDEGLFYLGKWEQPRKGSHNLEWLNLHEAVEKMAGAHHQWAVQEGISAVQTSTWF
>NC_016023.1|WP_017550244.1|2636430_2638020_-|phosphoenolpyruvate-carboxykinase-(ATP)
MKMDLIGASDDLKFLLSGENVRMQLSVPQLMEKIIERKEAVLTTEGAISAATGKYTGRSPKDKFIVVDSESKDRVDWGKINQPVSPGVFNRLYEKMVRHLKGKDEIFVFKGFAGADPKSRLPIQTVNEFAWHNLFAHQLFIRPDAEELYQHDAQFTILSAPLFKADPALDGTHSEAFIMISLERRIILIGGTEYAGEMKKSIFSIMNYLLPQKGILPMHCSANTGKNGDTALFFGLSGTGKTTLSADPERALIGDDEHGWSDSGVFNIEGGCYAKCIGLTEEKEPQIYQAIRFGTVLENVVVDPVSRKPQYDNNALTENTRAAYPIENIGNIARSGMAGHPSTIIFLTADASGVLPPISRLTKEQAMYHFLSGYTSKLAGTERGVTRPEAVFSTCFGAPFLPLEPAVYAEMLGEKVDRHNVQVFLVNTGWTGGPYGTGSRMKLSDTRAMVRAAINGKLKDTETRQDDIFGLHIPVHIEGVSDDVLYPADTWTDKQAYREKAFELAARFKENFRQFSVPDDIEKLGGPLI
>NC_016023.1|WP_014097654.1|2638484_2639696_+|methionine-adenosyltransferase
MLKGRHLFTSESVTEGHPDKICDQISDAILDAILEKDPNARVACETSVTTGLVLVTGEISTNTYVDIPKVVRKTIKEIGYTRAKYGFDAETCAVLTSIDEQSEDIARGVNQALEAREGGMSDEEIEAIGAGDQGLMFGFACNETEELMPLPISLAHKLARRLAELRKQEVIPYLRPDAKTQVTVEYDENNQPARIDTIVISTQHDPDTSAGQIQEDMKKYVIEPVVPAHLLDADTKYLINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGAFSGKDPTKVDRSAAYAARYVAKNIVAAGLAEKCEVQLAYAIGVAKPVSISIDTFGTGKVPEKVLIEAVEAHFDLRPAGIIKMLDLRRPIYRQIAAYGHFGRDDLDVPWEKTDKAGALNEFARNHIGK
>NC_016023.1|WP_014097655.1|2639926_2641825_+|asparagine-synthase-(glutamine-hydrolyzing)
MCGFIGCVHDHPVTLSDEDRQQFKQMNHMIEHRGPDDEGFYEDEHIQFGFRRLSIIDIEAGHQPLTYENERYWIIFNGEIYNYVELREELIKEGMTFETNSDTEVILAMYSRYGEKAIGRLRGMFGFAIWDKQEQTLCGARDPFGIKPFFYYEDGDKMYFGSEKKSILLAMEKPELNYDAVQYYLTYQFVPEPFTMTKGIRKLEPGHYFVKKIGKPMEIKRYWKASFHPVHKSEDEFIQEVRDVMIDSVKVHMRSDVPVGAFLSGGIDSSITASIAKQFHPGIKTFSVGFERDGYSEIDVAKETAEKLGVENISYVITPEEYMKELPKIIWHMDDPLADPACVPLYFVAREARKYVTVVLSGEGADELFGGYNIYREPQSLEVFDKIPAAGKSILKALAKVLPEGVKGKSFIERGVTPMEDRYIGNAKMYTEEEKRDLLLTYNNSLDYRDITKPLYNETKGYDPVNRMQYIDIHTWMRGDILLKADRMTMAHSLELRVPFLDKEVFRVASQIPASLKTSHNTTKYVLRKAAEGIVPEHVLNRKKLGFPVPIRHWLKDEMHDWAAEIIKTSPTDDIINKQYVLKLLEDHCAGKLDYSRKIWTVLIFMLWHAVYMEDKYDFQKGAQGRLAGASL
>NC_016023.1|WP_014097656.1|2642195_2642711_-|gamma-carbonic-anhydrase-family-protein
MIYAYNGKTPLIAPTAYIADNVTVTGDVEIGDESGIWFGTVIRGDVAPVKIGQKVNVQDNCVLHESPQTPLILEDEVTVGHQVILHSCHVRTKALIGMGSIILDGAEIGEGAFIGAGSLVTPGKKIPPHTLAFGRPAKVIRELTEKDIQDMRRIVREYAEKAQYYKNSVGR
>NC_016023.1|WP_014097657.1|2642869_2643676_+|alpha/beta-hydrolase
MWKWEADENPKAVIVIVHGAMEHHRRYSWLIEMWRSSGYHVVMGDLPGHGMTSRAKRGHIDSFDEYTTEIKEWVTAAYQFDLPIFLLGHSMGGLAVIRLLEQEHLKIAGVILSSPCLGLVQYPSKLLGLLSIGLNRIAPGLRFNSPLTVQMATRNKDIQMQAVNDSLMLTKVSVRWYRELLAAMRQAQMDTVRLPDVPFLVMQAGNDKIVDKGAVVNWFNQTSVSEKLYKEWPKCYHEIFNEPEREDVFLYAKNFVENRLRTLGYILE
>NC_016023.1|WP_014097658.1|2643686_2644781_+|tetraprenyl-beta-curcumene-synthase-family-protein
MTIPSYPISLMAQVYRRVMPAVHRELHYWREKARQIPNDELKTQALASIQHKTFHCEGGSILGLLAMEERTAAFRFIVAYQTISDYLDNLCDRSTSLDPVDFRALHESMSDALTVGAPLKNYYRYRLDQDDGGYLHELVRTCQVVLSRIPQYKAIQPYLLELCRYYSDLQVHKHVRVEERVPRLKEWFLRYKPDFPDMEWYEFSACSGSTLGIFCLVSYALRDDFRPEYATIIRDGYFPYIQGLHILLDYFIDQDEDKKGGDLNFCFYYPSEEELFKRLKHFLQEADKHTARLPNEKFHKLINRGLLAVYLSDEKVKKQRSVQKLSRKMIKFAGSISLFFYFNGKMYRAIKNMIPASLAKTIVK

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Crispr_ID: NC_016023_18

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016023_18

2795718-2795837

Orphan

Consensus_repeat	Method
TTCACCGGGTGGATGAAAGACAAAATG	PILER-CR

2 spacers

The CRISPR arrays of NC_016023_18

>merge|NC_016023|18|2795718-2795837|PILER-CR
GATGAAAGACAAAATGGTCGGCCAGGATTCTTGAACTGTCTTTCAGCGGGTGGATGAAAGACAGTTCGAGAGGCTGCGATCTTCTAAATGTTCTTCACCGGGTGGATGAAAGACAAAATG

>NC_016023|18|6|2795718-2795837|PILER-CR
GATGAAAGACAAAATGGTCGGCCAGGA	TTCTTGAACTGTCTTTCAGCGGGTG
GATGAAAGACAGTTCGAGAGGCTGCGA	TCTTCTAAATGTTCTTCACCGGGTGGATGA
AAGACAAAATG

Protein	Signature genes	Signature genes Name	Protein_function
NC_016023.1\|WP_014097785.1\|2793275_2793941_-\|7-cyano-7-deazaguanine-synthase-QueC	unknown	unknown	gnl\|CDD\|182967
NC_016023.1\|WP_014097790.1\|2796869_2797763_+\|cytochrome-b/b6-domain-containing-protein	unknown	unknown	gnl\|CDD\|379580
NC_016023.1\|WP_014097798.1\|2804849_2807264_+\|phenylalanine--tRNA-ligase-subunit-beta	unknown	unknown	gnl\|CDD\|234804
NC_016023.1\|WP_014097784.1\|2792294_2793227_-\|2-dehydropantoate-2-reductase	unknown	unknown	gnl\|CDD\|273247
NC_016023.1\|WP_014097795.1\|2802408_2803164_+\|RNA-methyltransferase	unknown	unknown	gnl\|CDD\|223640
NC_016023.1\|WP_014097779.1\|2785465_2786878_+\|O-antigen-ligase-family-protein	unknown	unknown	gnl\|CDD\|377422
NC_016023.1\|WP_014097797.1\|2803799_2804837_+\|phenylalanine--tRNA-ligase-subunit-alpha	unknown	unknown	gnl\|CDD\|234780
NC_016023.1\|WP_014097786.1\|2794549_2794885_+\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|367559
NC_016023.1\|WP_014097792.1\|2800276_2801638_+\|transposase	unknown	unknown	gnl\|CDD\|379252
NC_016023.1\|WP_013859878.1\|2808692_2808983_+\|cell-division-protein-ZapA	unknown	unknown	gnl\|CDD\|172616
NC_016023.1\|WP_014097781.1\|2787810_2788797_+\|zinc-binding-dehydrogenase	unknown	unknown	gnl\|CDD\|176232
NC_016023.1\|WP_014097787.1\|2794877_2795573_+\|DUF1129-family-protein	unknown	unknown	gnl\|CDD\|368981
NC_016023.1\|WP_013859890.1\|2794226_2794424_+\|hypothetical-protein	unknown	unknown	unknown
NC_016023.1\|WP_014097799.1\|2807656_2808592_-\|ribonuclease-HIII	unknown	unknown	gnl\|CDD\|234886
NC_016023.1\|WP_014097780.1\|2787304_2787796_+\|lactoylglutathione-lyase-family-protein	unknown	unknown	gnl\|CDD\|132684
NC_016023.1\|WP_014097788.1\|2796023_2796362_-\|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl\|CDD\|225209
NC_016023.1\|WP_014097793.1\|2801639_2802065_+\|hypothetical-protein	unknown	unknown	unknown
NC_016023.1\|WP_014097782.1\|2788947_2790276_-\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|214599
NC_016023.1\|WP_014097794.1\|2802091_2802304_-\|small-acid-soluble-spore-protein-SspI	unknown	unknown	gnl\|CDD\|179513
NC_016023.1\|WP_014097783.1\|2790524_2791079_-\|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223508

Protein	Function_ID	Function_description	E-value
NC_016023.1\|WP_014097785.1\|2793275_2793941_-\|7-cyano-7-deazaguanine-synthase-QueC	gnl\|CDD\|182967	PRK11106, PRK11106, queuosine biosynthesis protein QueC; Provisional.	8.66111e-125
NC_016023.1\|WP_014097790.1\|2796869_2797763_+\|cytochrome-b/b6-domain-containing-protein	gnl\|CDD\|379580	pfam14358, DUF4405, Domain of unknown function (DUF4405). This presumed domain is functionally uncharacterized. This domain family is found in bacteria and archaea, and is approximately 50 amino acids in length. There are two conserved histidines that may be functionally important. This family is N-terminally truncated compared to other members of the clan.	5.74338e-10
NC_016023.1\|WP_014097798.1\|2804849_2807264_+\|phenylalanine--tRNA-ligase-subunit-beta	gnl\|CDD\|234804	PRK00629, pheT, phenylalanyl-tRNA synthetase subunit beta; Reviewed.	0
NC_016023.1\|WP_014097788.1\|2796023_2796362_-\|antibiotic-biosynthesis-monooxygenase	gnl\|CDD\|225209	COG2329, COG2329, Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only].	1.99476e-19
NC_016023.1\|WP_014097795.1\|2802408_2803164_+\|RNA-methyltransferase	gnl\|CDD\|223640	COG0566, SpoU, rRNA methylases [Translation, ribosomal structure and biogenesis].	1.67497e-72
NC_016023.1\|WP_014097797.1\|2803799_2804837_+\|phenylalanine--tRNA-ligase-subunit-alpha	gnl\|CDD\|234780	PRK00488, pheS, phenylalanyl-tRNA synthetase subunit alpha; Validated.	0
NC_016023.1\|WP_014097784.1\|2792294_2793227_-\|2-dehydropantoate-2-reductase	gnl\|CDD\|273247	TIGR00745, Putative_2-dehydropantoate_2-reductase, 2-dehydropantoate 2-reductase. This model describes enzymes that perform as 2-dehydropantoate 2-reductase, one of four enzymes required for the de novo biosynthesis of pantothenate (vitamin B5) from Asp and 2-oxoisovalerate. Although few members of the seed alignment are characterized experimentally, nearly all from complete genomes are found in a genome-wide (but not local) context of all three other pantothenate-biosynthetic enzymes (TIGR00222, TIGR00018, TIGR00223). The gene encoding this enzyme is designated apbA in Salmonella typhimurium and panE in Escherichia coli; this protein functions as a monomer and functions in the alternative pyrimidine biosynthetic, or APB, pathway, used to synthesize the pyrimidine moiety of thiamine. Note, synthesis of the pyrimidine moiety of thiamine occurs either via the first five steps in de novo purine biosynthesis, which uses the pur gene products, or through the APB pathway. Note that this family includes both NADH and NADPH-dependent enzymes, and enzymes with broad specificity, such as a D-mandelate dehydrogease that is also a 2-dehydropantoate 2-reductase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pantothenate and coenzyme A].	1.02358e-55
NC_016023.1\|WP_014097786.1\|2794549_2794885_+\|PadR-family-transcriptional-regulator	gnl\|CDD\|367559	pfam03551, PadR, Transcriptional regulator PadR-like family. Members of this family are transcriptional regulators that appear to be related to the pfam01047 family. This family includes PadR, a protein that is involved in negative regulation of phenolic acid metabolism.	5.50707e-24
NC_016023.1\|WP_014097792.1\|2800276_2801638_+\|transposase	gnl\|CDD\|379252	pfam13546, DDE_5, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	2.31725e-16
NC_016023.1\|WP_014097781.1\|2787810_2788797_+\|zinc-binding-dehydrogenase	gnl\|CDD\|176232	cd08271, MDR5, Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family. This group is a member of the medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, but lacks the zinc-binding sites of the zinc-dependent alcohol dehydrogenases. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P)-binding Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	1.38308e-140
NC_016023.1\|WP_014097787.1\|2794877_2795573_+\|DUF1129-family-protein	gnl\|CDD\|368981	pfam06570, DUF1129, Protein of unknown function (DUF1129). This family consists of several hypothetical bacterial proteins of unknown function.	8.95977e-13
NC_016023.1\|WP_014097779.1\|2785465_2786878_+\|O-antigen-ligase-family-protein	gnl\|CDD\|377422	pfam04932, Wzy_C, O-Antigen ligase. This group of bacterial proteins is involved in the synthesis of O-antigen, a lipopolysaccharide found in the outer membrane in gram-negative bacteria. This family includes O-antigen ligases such as E. coli RfaL.	3.83924e-08
NC_016023.1\|WP_014097799.1\|2807656_2808592_-\|ribonuclease-HIII	gnl\|CDD\|234886	PRK00996, PRK00996, ribonuclease HIII; Provisional.	1.78322e-157
NC_016023.1\|WP_014097780.1\|2787304_2787796_+\|lactoylglutathione-lyase-family-protein	gnl\|CDD\|132684	TIGR03645, glyox_marine, lactoylglutathione lyase family protein. Members of this protein family share homology with lactoylglutathione lyase (glyoxalase I) and are found mainly in marine members of the gammaproteobacteria, including CPS_0532 from Colwellia psychrerythraea 34H. This family excludes a well-separated, more narrowly distributed paralogous family, exemplified by CPS_3492 from C. psychrerythraea. The function is of this protein family is unknown.	1.15755e-109
NC_016023.1\|WP_014097794.1\|2802091_2802304_-\|small-acid-soluble-spore-protein-SspI	gnl\|CDD\|179513	PRK02955, PRK02955, small acid-soluble spore protein SspI; Provisional.	6.54482e-32
NC_016023.1\|WP_013859878.1\|2808692_2808983_+\|cell-division-protein-ZapA	gnl\|CDD\|172616	PRK14126, PRK14126, cell division protein ZapA; Provisional.	2.3583e-37
NC_016023.1\|WP_014097782.1\|2788947_2790276_-\|HAMP-domain-containing-protein	gnl\|CDD\|214599	smart00283, MA, Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.	8.02706e-47
NC_016023.1\|WP_014097783.1\|2790524_2791079_-\|NAD(P)H-dependent-oxidoreductase	gnl\|CDD\|223508	COG0431, COG0431, Predicted flavoprotein [General function prediction only].	1.02316e-43

>NC_016023.1|WP_014097787.1|2794877_2795573_+|DUF1129-family-protein
MLSVKQLIEENNRKRQELAPENKKFYNDMLDYLRLQTVLSEQQTEEVLMELLDHLLEGQKENKTAAQMFGGDPKAFADEIIRQLPKENKRNMVSFTIRIMILLLGIDLVINGITAFVVERFFSRPLPPFYPVPAALNFFIAGLYVIFAIWYIFRILKKSLFKEKTKKVQILTFLKIDAVIFVFLGGVILLDKFMPKIGPSFSYPWWLPLVLGVVSLGVYYSWEKAAKSRGI
>NC_016023.1|WP_014097786.1|2794549_2794885_+|PadR-family-transcriptional-regulator
MSIRSQLLKGILDGCVLAVIEKEPVYGYILSKKLQQLGLQEISEGTLYPVLLRLQKNGWIHGEMQPSDSGPSRKYYELTEKGKSALDEITAEWQRIAAPVNLLLKGRSEDA
>NC_016023.1|WP_013859890.1|2794226_2794424_+|hypothetical-protein
MKRYVQLFFMFAVTVLIVMGIQKGLSTLNVLNLENFWANYVVFLILAYMILSFFLHYFSKRKKQS
>NC_016023.1|WP_014097785.1|2793275_2793941_-|7-cyano-7-deazaguanine-synthase-QueC
MKKEKAVVVFSGGQDSTTCLFWAKKKFQEVEAVTFDYGQRHRLEIECAKNIAEELGVKQHILDMQLLNQLAPNALTRESITVKAGADGELPNTFVPGRNLLFLSFAGVLASQIGARHIVTGVCETDFSGYPDCRDIFIKSLNVTLNLSMDQQFVIHTPLMWRNKAETWALADELGAFDFVREKTLTCYNGIIADGCGECPACKLRKRGLEQYLAIRNGQSE
>NC_016023.1|WP_014097784.1|2792294_2793227_-|2-dehydropantoate-2-reductase
MAEIKTVSIIGLGALGILFGHHLSKKMPAKNLRIIADQQRIERYEREGVYCNGEKCHFHYVTPEETVEPADLVLFTVKFNGLDEAVEAVKQHVGPDTVILSALNGISSEEIIGRTYGMDKMLYCVAQGMDAVKTGNQLTYAHMGMLCFGEKEPGLFSDKMKKVARFFEQTDLPYEADTEMMKRLWGKFMLNVGVNQTVAVYKSNYGEIQKDGPAREMMIAAMREVEALSEKEGFPLTEEDLRYWLKVVGNLSPAGKPSMAQDVEAKRYSEVGLFSGTVIKLGKKYGVQVPVNEELNRRIREIESTYTAVH
>NC_016023.1|WP_014097783.1|2790524_2791079_-|NAD(P)H-dependent-oxidoreductase
MTKVGILLGSLRKASFSRKLAENVANLFPEGYETEFVEIGNLPLYNQDFDDHNQVPAEYTTFRNTVKGLDAVLFVTPEYNRSIPAVLKNAIDVGSRPYGQSIWDGKPAAIISQSPGNLSGFGANHHLRQSLVCLNMPILQQPEAYIGNVTALFDENGKIVNEGTVRFLQSFTDAFVDLIKKYKG
>NC_016023.1|WP_014097782.1|2788947_2790276_-|HAMP-domain-containing-protein
MLKNVKKISFKIIMLSVLNSVIVIAINIGASVYGNIGKGNSGTGNHVPPAGIAIIPTNVLIGLFISLIIGIILSYILGRVISKPILQTAELAEQTAALDLREENGSFDKIQSFQDETGKLARALRQTRISLREVAKRLKEFSSKVATHTDTLSKRTEESFQSINQVASSIDEFAQGNSQLSETVHDINKTLNEVVNLIETITQEAANGAEHAAASLDAVKEGQNTIDHQFKKIDQNIEITATANESITELSGMIDQVQAFVNVITSIAEQTNLLALNASIEASRAGDAGRGFAVVAGEIRKLAEGSSKAAREIKDLIATTTKKSNAAVENISKANAFIHEQKDAFHKTEAAFHQIQHTYSNIVGSFQHTAEGIETINEKSKQISKRIQEITSTVENFAASSEEMSASGQEQRAFTEIISQSAKELQELAGKLDTEMNKFKVS
>NC_016023.1|WP_014097781.1|2787810_2788797_+|zinc-binding-dehydrogenase
MKGWLIGKPASIDDLTWGEVPDPRAGEGQLVVKVMSTALNPVDYQLIESGNPNWVYPHITGVDLAGEVVEVGPDPSGFKTGDRIACHTDLNRKGAFAQFAAIDANAAAKIPDGVSYDEAVAVLCAGMTAYQAVVQKLNHTDKQTILIHAGAGGVGGFAIQLAKELGLKVFTTASAANHEWVKSLGADTAIDYHTEDVTKRIMEETDGEGVDLILNTVSFAEATEDLKRLAFSGQLAYIAGAPDLSGIKPFTLAPSIHEVALGAAHASGSVRAKQNLAFMADELMQRVKKGTLNPMVNQVLPREELPAGLKTLKGRHVRGKIIVRMHEA
>NC_016023.1|WP_014097780.1|2787304_2787796_+|lactoylglutathione-lyase-family-protein
MTYPRSFSHIGLSVPDLDKAVQFYTEVMGWYVIMEPSEIKEDDSAIGIMCKDVFGSGWGSFRIAHLAMGDGTGVEMFEFKNNETPDNNFEYWKTGIFHYAVQDPDVEGLVEKIKAHGGKQRMPIREYYPGKKPYRMVYCEDPFGNLVEIYSHSYELTYSEGAY
>NC_016023.1|WP_014097779.1|2785465_2786878_+|O-antigen-ligase-family-protein
MNSLIHFIKEHAFELAAVLCFALPPVGLFIMLVFSLSELYRHIKNKRLFSSSPVSFFFLCLLAATTGAAVQMGEPLLLAESLRILFYWGIFLKIMDSGTRGRFKHFRWIVIGCGLYGIFIGWLPKMLSDDPVLAFLTGTELFGFKHYNRLIGSTYNPNFTMFLLLIGISFLFAEMLKDAGKKDWKNLIWKCIPLFFLSKGVFDTGSRAGFISMICIYFIFFFRWNKWIFGGGLLFLALGAGKLAAVIPRVHSIEGSLTGREKIWYHSYKIFETHFLFGTTPLGFGKVYASLFHKNIYHAHDIFIGFFVEYGAIGGIAFLAVLAMGVCKLGRLFFIKRNYRYLNIFLLSLPVIVLTGFLDEPVFSPQIGMLAVVLLSYWERYSKRMFQPHVAFLNRLNVKHNILKRQLPKPELQSISRAITGEIKAIESVVHETAEPFEICKKEARNNRGKPDEKTPDKELSDKTPDKENE
>NC_016023.1|WP_014097788.1|2796023_2796362_-|antibiotic-biosynthesis-monooxygenase
MFVQLRRMTVAKGHADQVIERFSKPGIIEQQEGFVDIKIMQKKQGRGEEEVIVMITWESETHWKQWEKSDVHIAGHRANRGKSKPDYMLNMELGMYEVKAVKKAAGKAEISE
>NC_016023.1|WP_014097790.1|2796869_2797763_+|cytochrome-b/b6-domain-containing-protein
MCRGGAEDEKNYAKFAIDLFMAIMFVLFFNKNVLGGLAYHEIAGLVFGVVFLTHVCLNLNWVKNVTLKMFDKRLPWKARGSYALNLLLLISMCFIIISGIIISRVVFPNINLGNEGWFKTTHISVSFLVLILVGVHVGLHWHWVVNVFKRMVHFKAKNKWAGYVAKVAATLILVFSSCEIIQTGFLNRMASAASIFGGSTGNSEMEGHHDFNGKSGQKSDFTNGQRLDFTNGQKPAFANEKKPDFADGDRRGGGDHDGGSANVLTVLLTYTGIMSAFVVLTYYLRKLTVRKKRRKTA
>NC_016023.1|WP_014097792.1|2800276_2801638_+|transposase
MIDQNCQYNQLPKELDSVFSELEMKKHLRHAGIKKSFGFSCSYLFQLVFCLIFQHKNWFSLLESKKADQFPAKDAVYRFLNQSTFNWRQFLLLLSTFTIRKVERLTDKSRPKVFIVDDSSFYRNRSQKVELLARCFDHASLKMRFYKGFRMLTLGWSDGYTFMPIDFSLLSSKKAQINGISEQIDKRTCGYKRRKNALQSEPEQIPSMLKRALASGINASYVLMDSWFTLPPLVKAIVEQGLDVIGMVKETKQRYNVDGKLVSLKQLYRLAQPLQSKKGILRSIRTVMANGTPVKVIFVQNRNKKSEWLALLSTDCTLSEQEIVRIYGMRWDIEVFFKTTKSLLKLEKELQSRSYDGLISHTTIVFARFIVLSWQNRCNTDQRTIGRLFYELCDEVNELDWAVALQQLIELLQDALKQTNKRFKKLIQSQLEQWISGLPSYIKAYLPISLCES
>NC_016023.1|WP_014097793.1|2801639_2802065_+|hypothetical-protein
MKEKDFVAFLTEAGRYDKTAEKCTVCGIILPSFSDYLLRGPAGALGTKYNVLSYSEQGLTVIPINNITGNMLPDESAFIPGEKITSMKTVPKLTYHRLYVGTSDGTAVFRLNKVLIGYGWHKRNLPSFIATVNGLEEPVHI
>NC_016023.1|WP_014097794.1|2802091_2802304_-|small-acid-soluble-spore-protein-SspI
MDLDLRKAVIHNVKEDTQDQLKDTIVDAIQRGEEKMLPGLGVLFEVIWNHADTQEQKMMLETLEQGLSQA
>NC_016023.1|WP_014097795.1|2802408_2803164_+|RNA-methyltransferase
MKYIQSLQNPQVKHWKKLTAKKEREKTFTYLLEGFHLVEEALKEEVVTEIIVEEGVDLPNRWNTEGVPVTTVTHEISKTLADTETTQGIFAVCRMKKQPSKIIGRRYLLIDAVQDPGNTGTMIRTADAAGFDAVIFGKGTADPYSPKVLRAAQGSHLHVGLLKGDLNMWIEKLNEAAVPVYGTALENGVTFREVNPGDAFAILVGNEGSGVHPDLLAQTEQNLSIPIFGKSESLNVAVAAGILMYDFAMRS
>NC_016023.1|WP_014097797.1|2803799_2804837_+|phenylalanine--tRNA-ligase-subunit-alpha
MEETLKALQTEALAKIGAAADLKTLNEIRVAYLGKKGPITEVLRGMGKLSAEERPKMGALANEVRAAIQTGIEKKQAALEAEAVERQLASEKIDVTLPGRPVKAGSHHPLTKVIEEIEDLFIGMGYTIAEGPEVETDYYNFEALNLPKGHPARDMQDTFYITDDILLRTHTSPNQARTMEKHHGKGPVKIICPGKVYRRDNDDATHSHQFMQIEGLVVDENITMADLKGTLEVFAKKLFGEDREIRLRPSFFPFTEPSVEMDISCKMCGGHGCHVCKGTGWIEILGAGMVHPRVLRMSGFDPEKYTGFAFGMGPERIAMLKYGVDDIRHFYTNDIRFLRQFSVQE
>NC_016023.1|WP_014097798.1|2804849_2807264_+|phenylalanine--tRNA-ligase-subunit-beta
MFVSYKWLQEYVDLDGISPEELAEKITRTGIEVESVAFKGEGIKNVVVGHVLEKEKHPNADKLNKCLVDIGEGEPVQIICGAPNVDKGQKVAVAKPGAWLPGHVKIKRSKLRGEESNGMICSLQELGVESKLVQKEYANGIYVFPDDVEVGKDVLPLLGLDDTIIELGLTPNRADCMSMLGVAYEVAAILGKDVKLPETKVQEASDKAADAISVRVEAKEAAPLYTLKVIRNVKIGPSPLWMQARLMAEGIRPHNNVVDITNYILLEYGQPLHAFDYDKLGSKEIVVRMAREGEKMVTLDDQERTLKDVHLVITNGTEPVAMAGVMGGANSEVSETTTNVLLESAYFDAGTIRTASKDHGLRSEASSRYERGIDPNRVVPAAERAAMLIAKYAGGEVLAGMVAENHLHIEPAVVTITLEKINRVLGTQISAEEVLRIFKRLQFETSWEDGRFTVIVPTRRGDITIEEDLIEEVARLYGYDLLPKTLPAGRGTRGGLNVIQQKRRATKRFLEGTGLYQATTYSLTSEEKAHQYALEKREPVRVAMPMSEERSVLRLSLLPHLLESVAYNVARKNESVALYEVGNVFLKKADGAQPEEQEHLAGAITGLWVSNLWQGEKKAVDFFVAKGILEGLFEKLGVSGAISYHAATFEGLHPGRTAEILLDGEAIGFVGQVHPNVQKELDIKETYVFELKLEPVYHYPAEPVQYRPIPRFPAITRDIALVVDRDVEAARLQAIIQEAGGTLLKSVSIFDLYEGEHMEPDKKSIAFSLTYFDPERTLTDEEVVAQHEKVLAAVKEKAGAVLRG
>NC_016023.1|WP_014097799.1|2807656_2808592_-|ribonuclease-HIII
MSNTVILVSASTMQKMKQSYQNSLSGKVPSGAVFAAKIPGCSITGYKSGKVLFQGPAAETEASKWGQPLEKKPDAARSAKSSGNPLPPDIGELSVIGSDEVGTGDFFGPMTVVSCYVEKKQLPLLKELGVKDSKGLTDSQIAGLAKELLTFVPYSLLILPNEKYNRLQQSGMSQGKIKALLHNRALYNTAQKIAPAKPDAILIDQFAEASTYYRYLQNEKIVMRDGVYFSTKGESVHLAVAAASILARYAFVREFEKLSKEAGFVLPKGAGAQVDRAAARLIKEKGMAALPHFVKLHFANTEKAKRIAGVK
>NC_016023.1|WP_013859878.1|2808692_2808983_+|cell-division-protein-ZapA
MGRQATLEKTRITVGIYGQQYTIIGTDPASHIRLVASMVDERMREISAKNPSLDTGKVAVLTAVNAVHDYIKLKEQYELLEQHYLQLLKKDEDENG

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_016023_2	2.3\|320765\|27\|NC_016023\|CRT	320765-320791	27	NC_016023.1	2593882-2593908	1	0.963
NC_016023_2	2.3\|320765\|27\|NC_016023\|CRT	320765-320791	27	NC_016023.1	2594141-2594167	1	0.963
NC_016023_2	2.3\|320765\|27\|NC_016023\|CRT	320765-320791	27	NC_016023.1	2594660-2594686	1	0.963
NC_016023_2	2.3\|320765\|27\|NC_016023\|CRT	320765-320791	27	NC_016023.1	1300106-1300132	2	0.926
NC_016023_2	2.3\|320765\|27\|NC_016023\|CRT	320765-320791	27	NC_016023.1	2593830-2593856	2	0.926
NC_016023_2	2.3\|320765\|27\|NC_016023\|CRT	320765-320791	27	NC_016023.1	2594038-2594064	2	0.926
NC_016023_2	2.3\|320765\|27\|NC_016023\|CRT	320765-320791	27	NC_016023.1	2594090-2594116	2	0.926
NC_016023_2	2.3\|320765\|27\|NC_016023\|CRT	320765-320791	27	NC_016023.1	2594453-2594479	2	0.926
NC_016023_2	2.3\|320765\|27\|NC_016023\|CRT	320765-320791	27	NC_016023.1	2594505-2594531	2	0.926
NC_016023_2	2.3\|320765\|27\|NC_016023\|CRT	320765-320791	27	NC_016023.1	2594712-2594738	2	0.926
NC_016023_2	2.3\|320765\|27\|NC_016023\|CRT	320765-320791	27	NC_016023.1	2594764-2594790	2	0.926
NC_016023_2	2.3\|320765\|27\|NC_016023\|CRT	320765-320791	27	NC_016023.1	2594816-2594842	2	0.926
NC_016023_2	2.6\|320921\|27\|NC_016023\|CRT	320921-320947	27	NC_016023.1	2594816-2594842	2	0.926
NC_016023_2	2.7\|320973\|27\|NC_016023\|CRT	320973-320999	27	NC_016023.1	2594816-2594842	2	0.926

1. spacer 2.3|320765|27|NC_016023|CRT matches to position: 2593882-2593908, mismatch: 1, identity: 0.963

cacgctgcatccgggcccgaaatgtct	CRISPR spacer
cacgctgcacccgggcccgaaatgtct	Protospacer
*********.*****************

2. spacer 2.3|320765|27|NC_016023|CRT matches to position: 2594141-2594167, mismatch: 1, identity: 0.963

cacgctgcatccgggcccgaaatgtct	CRISPR spacer
cacgctgcatccgagcccgaaatgtct	Protospacer
*************.*************

3. spacer 2.3|320765|27|NC_016023|CRT matches to position: 2594660-2594686, mismatch: 1, identity: 0.963

cacgctgcatccgggcccgaaatgtct	CRISPR spacer
cacgctgcatccgagcccgaaatgtct	Protospacer
*************.*************

4. spacer 2.3|320765|27|NC_016023|CRT matches to position: 1300106-1300132, mismatch: 2, identity: 0.926

cacgctgcatccgggcccgaaatgtct	CRISPR spacer
caagctgcatccgggtccgaaatgtct	Protospacer
** ************.***********

5. spacer 2.3|320765|27|NC_016023|CRT matches to position: 2593830-2593856, mismatch: 2, identity: 0.926

cacgctgcatccgggcccgaaatgtct	CRISPR spacer
cacggtgcatccgagcccgaaatgtct	Protospacer
**** ********.*************

6. spacer 2.3|320765|27|NC_016023|CRT matches to position: 2594038-2594064, mismatch: 2, identity: 0.926

cacgctgcatccgggcccgaaatgtct	CRISPR spacer
caagctgcatccgggtccgaaatgtct	Protospacer
** ************.***********

7. spacer 2.3|320765|27|NC_016023|CRT matches to position: 2594090-2594116, mismatch: 2, identity: 0.926

cacgctgcatccgggcccgaaatgtct	CRISPR spacer
cacgctgcacccgagcccgaaatgtct	Protospacer
*********.***.*************

8. spacer 2.3|320765|27|NC_016023|CRT matches to position: 2594453-2594479, mismatch: 2, identity: 0.926

cacgctgcatccgggcccgaaatgtct	CRISPR spacer
cacgctgcatccgggctcggaatgtct	Protospacer
****************.**.*******

9. spacer 2.3|320765|27|NC_016023|CRT matches to position: 2594505-2594531, mismatch: 2, identity: 0.926

cacgctgcatccgggcccgaaatgtct	CRISPR spacer
cacgctgcatccgaacccgaaatgtct	Protospacer
*************..************

10. spacer 2.3|320765|27|NC_016023|CRT matches to position: 2594712-2594738, mismatch: 2, identity: 0.926

cacgctgcatccgggcccgaaatgtct	CRISPR spacer
cacgctgcacccgagcccgaaatgtct	Protospacer
*********.***.*************

11. spacer 2.3|320765|27|NC_016023|CRT matches to position: 2594764-2594790, mismatch: 2, identity: 0.926

cacgctgcatccgggcccgaaatgtct	CRISPR spacer
cacgctgcacccgagcccgaaatgtct	Protospacer
*********.***.*************

12. spacer 2.3|320765|27|NC_016023|CRT matches to position: 2594816-2594842, mismatch: 2, identity: 0.926

cacgctgcatccgggcccgaaatgtct	CRISPR spacer
cacgttgcatccgggctcgaaatgtct	Protospacer
****.***********.**********

13. spacer 2.6|320921|27|NC_016023|CRT matches to position: 2594816-2594842, mismatch: 2, identity: 0.926

cacgtttcatccgagctcgaaatgtct	CRISPR spacer
cacgttgcatccgggctcgaaatgtct	Protospacer
****** ******.*************

14. spacer 2.7|320973|27|NC_016023|CRT matches to position: 2594816-2594842, mismatch: 2, identity: 0.926

cacgtttcatccgagctcgaaatgtct	CRISPR spacer
cacgttgcatccgggctcgaaatgtct	Protospacer
****** ******.*************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_016023_11	11.60\|2121400\|35\|NC_016023\|CRISPRCasFinder,CRT	2121400-2121434	35	LT960610	Bacillus phage SBSphiC genome assembly, complete genome: monopartite	88213-88247	4	0.886
NC_016023_11	11.84\|2121401\|35\|NC_016023\|PILER-CR	2121401-2121435	35	LT960610	Bacillus phage SBSphiC genome assembly, complete genome: monopartite	88213-88247	4	0.886
NC_016023_2	2.8\|321025\|27\|NC_016023\|CRT	321025-321051	27	MK359332	Streptomyces phage Genie2, complete genome	33877-33903	5	0.815
NC_016023_2	2.8\|321025\|27\|NC_016023\|CRT	321025-321051	27	MK359351	Streptomyces phage BoomerJR, complete genome	33763-33789	5	0.815
NC_016023_2	2.8\|321025\|27\|NC_016023\|CRT	321025-321051	27	MH727564	Streptomyces phage Yaboi, complete genome	33854-33880	5	0.815
NC_016023_2	2.10\|321129\|27\|NC_016023\|CRT	321129-321155	27	MK359332	Streptomyces phage Genie2, complete genome	33877-33903	5	0.815
NC_016023_2	2.10\|321129\|27\|NC_016023\|CRT	321129-321155	27	MK359351	Streptomyces phage BoomerJR, complete genome	33763-33789	5	0.815
NC_016023_2	2.10\|321129\|27\|NC_016023\|CRT	321129-321155	27	MH727564	Streptomyces phage Yaboi, complete genome	33854-33880	5	0.815
NC_016023_11	11.21\|2118798\|35\|NC_016023\|PILER-CR,CRISPRCasFinder,CRT	2118798-2118832	35	NZ_CP026096	Bacillus asahii strain OM18 plasmid pOM18, complete sequence	26956-26990	5	0.857
NC_016023_11	11.51\|2120803\|37\|NC_016023\|CRISPRCasFinder,CRT	2120803-2120839	37	MN693342	Marine virus AFVG_25M9, complete genome	34997-35033	6	0.838
NC_016023_11	11.75\|2120804\|37\|NC_016023\|PILER-CR	2120804-2120840	37	MN693342	Marine virus AFVG_25M9, complete genome	34997-35033	6	0.838
NC_016023_16	16.1\|2614657\|55\|NC_016023\|CRISPRCasFinder	2614657-2614711	55	NZ_LR134399	Listeria monocytogenes strain NCTC7974 plasmid 2, complete sequence	57355-57409	6	0.891
NC_016023_11	11.12\|2118199\|35\|NC_016023\|PILER-CR,CRISPRCasFinder,CRT	2118199-2118233	35	MF360958	Salicola phage SCTP-2, complete genome	150015-150049	7	0.8
NC_016023_16	16.1\|2614657\|55\|NC_016023\|CRISPRCasFinder	2614657-2614711	55	NZ_CP015440	Anoxybacillus amylolyticus strain DSM 15939 plasmid pDSM15939_2, complete sequence	64784-64838	7	0.873
NC_016023_11	11.12\|2118199\|35\|NC_016023\|PILER-CR,CRISPRCasFinder,CRT	2118199-2118233	35	AP014323	Uncultured Mediterranean phage uvMED isolate uvMED-GF-U-MedDCM-OCT-S33-C38, * SEQUENCING IN PROGRESS *	32800-32834	8	0.771
NC_016023_11	11.51\|2120803\|37\|NC_016023\|CRISPRCasFinder,CRT	2120803-2120839	37	NZ_CP031220	Arcobacter mytili LMG 24559 plasmid pAMYT, complete sequence	73027-73063	8	0.784
NC_016023_11	11.75\|2120804\|37\|NC_016023\|PILER-CR	2120804-2120840	37	NZ_CP031220	Arcobacter mytili LMG 24559 plasmid pAMYT, complete sequence	73027-73063	8	0.784
NC_016023_16	16.1\|2614657\|55\|NC_016023\|CRISPRCasFinder	2614657-2614711	55	NZ_CP015439	Anoxybacillus amylolyticus strain DSM 15939 plasmid pDSM15939_1, complete sequence	255881-255935	8	0.855
NC_016023_6	6.17\|1097145\|36\|NC_016023\|CRISPRCasFinder,CRT	1097145-1097180	36	NZ_CP013981	Staphylococcus equorum strain KM1031 plasmid unnamed1, complete sequence	5582-5617	9	0.75
NC_016023_6	6.17\|1097145\|36\|NC_016023\|CRISPRCasFinder,CRT	1097145-1097180	36	NZ_CP013981	Staphylococcus equorum strain KM1031 plasmid unnamed1, complete sequence	40571-40606	9	0.75
NC_016023_6	6.17\|1097145\|36\|NC_016023\|CRISPRCasFinder,CRT	1097145-1097180	36	NC_013348	Staphylococcus aureus plasmid pSK156, complete sequence	29812-29847	9	0.75
NC_016023_6	6.17\|1097145\|36\|NC_016023\|CRISPRCasFinder,CRT	1097145-1097180	36	NC_009130	Staphylococcus sp. 693-2 plasmid pLEW6932, complete sequence	15353-15388	9	0.75
NC_016023_6	6.17\|1097145\|36\|NC_016023\|CRISPRCasFinder,CRT	1097145-1097180	36	CP027495	Staphylococcus aureus strain ST2594 isolate 004 plasmid unnamed10	3470-3505	9	0.75
NC_016023_6	6.17\|1097145\|36\|NC_016023\|CRISPRCasFinder,CRT	1097145-1097180	36	MN693588	Marine virus AFVG_25M366, complete genome	20597-20632	9	0.75
NC_016023_6	6.45\|1097146\|36\|NC_016023\|PILER-CR	1097146-1097181	36	NZ_CP013981	Staphylococcus equorum strain KM1031 plasmid unnamed1, complete sequence	5582-5617	9	0.75
NC_016023_6	6.45\|1097146\|36\|NC_016023\|PILER-CR	1097146-1097181	36	NZ_CP013981	Staphylococcus equorum strain KM1031 plasmid unnamed1, complete sequence	40571-40606	9	0.75
NC_016023_6	6.45\|1097146\|36\|NC_016023\|PILER-CR	1097146-1097181	36	NC_013348	Staphylococcus aureus plasmid pSK156, complete sequence	29812-29847	9	0.75
NC_016023_6	6.45\|1097146\|36\|NC_016023\|PILER-CR	1097146-1097181	36	NC_009130	Staphylococcus sp. 693-2 plasmid pLEW6932, complete sequence	15353-15388	9	0.75
NC_016023_6	6.45\|1097146\|36\|NC_016023\|PILER-CR	1097146-1097181	36	CP027495	Staphylococcus aureus strain ST2594 isolate 004 plasmid unnamed10	3470-3505	9	0.75
NC_016023_6	6.45\|1097146\|36\|NC_016023\|PILER-CR	1097146-1097181	36	MN693588	Marine virus AFVG_25M366, complete genome	20597-20632	9	0.75
NC_016023_12	12.2\|2123969\|35\|NC_016023\|CRISPRCasFinder,CRT,PILER-CR	2123969-2124003	35	NZ_CP013710	Clostridium botulinum strain F634 plasmid pRSJ2_3, complete sequence	20011-20045	9	0.743
NC_016023_12	12.2\|2123969\|35\|NC_016023\|CRISPRCasFinder,CRT,PILER-CR	2123969-2124003	35	NZ_CP014152	Clostridium botulinum strain BrDura plasmid pRSJ20_1, complete sequence	18264-18298	9	0.743
NC_016023_16	16.1\|2614657\|55\|NC_016023\|CRISPRCasFinder	2614657-2614711	55	NZ_CP024037	Bacillus aryabhattai strain K13 plasmid unnamed2	10428-10482	9	0.836
NC_016023_16	16.1\|2614657\|55\|NC_016023\|CRISPRCasFinder	2614657-2614711	55	NZ_CP026740	Bacillus megaterium strain YC4-R4 plasmid unnamed4	70775-70829	9	0.836
NC_016023_16	16.1\|2614657\|55\|NC_016023\|CRISPRCasFinder	2614657-2614711	55	NZ_CP010587	Bacillus megaterium Q3 plasmid p1, complete sequence	832-886	9	0.836
NC_016023_16	16.1\|2614657\|55\|NC_016023\|CRISPRCasFinder	2614657-2614711	55	NZ_CP023319	Bacillus megaterium strain A plasmid p2, complete sequence	75819-75873	9	0.836
NC_016023_16	16.1\|2614657\|55\|NC_016023\|CRISPRCasFinder	2614657-2614711	55	NC_017139	Bacillus megaterium WSH-002 plasmid WSH-002_p1, complete sequence	1329-1383	9	0.836
NC_016023_16	16.1\|2614657\|55\|NC_016023\|CRISPRCasFinder	2614657-2614711	55	NC_020451	Vibrio coralliilyticus strain ATCC BAA-450 plasmid, complete sequence	1971-2025	9	0.836
NC_016023_6	6.15\|1097015\|35\|NC_016023\|CRISPRCasFinder,CRT	1097015-1097049	35	NZ_CP046333	Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3	676437-676471	10	0.714
NC_016023_6	6.15\|1097015\|35\|NC_016023\|CRISPRCasFinder,CRT	1097015-1097049	35	NC_007974	Cupriavidus metallidurans CH34 megaplasmid, complete sequence	370780-370814	10	0.714
NC_016023_6	6.43\|1097016\|35\|NC_016023\|PILER-CR	1097016-1097050	35	NZ_CP046333	Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3	676437-676471	10	0.714
NC_016023_6	6.43\|1097016\|35\|NC_016023\|PILER-CR	1097016-1097050	35	NC_007974	Cupriavidus metallidurans CH34 megaplasmid, complete sequence	370780-370814	10	0.714
NC_016023_11	11.22\|2118863\|37\|NC_016023\|PILER-CR,CRISPRCasFinder,CRT	2118863-2118899	37	NZ_CP017105	Rhizobium gallicum strain IE4872 plasmid pRgalIE4872d, complete sequence	1805714-1805750	10	0.73
NC_016023_16	16.1\|2614657\|55\|NC_016023\|CRISPRCasFinder	2614657-2614711	55	NC_048753	Lactobacillus phage 3-521, complete genome	13549-13603	10	0.818
NC_016023_11	11.8\|2117930\|35\|NC_016023\|PILER-CR,CRISPRCasFinder,CRT	2117930-2117964	35	NZ_CP054621	Azospirillum oryzae strain KACC 14407 plasmid unnamed6, complete sequence	490990-491024	11	0.686
NC_016023_16	16.1\|2614657\|55\|NC_016023\|CRISPRCasFinder	2614657-2614711	55	NZ_CP033045	Bacillus foraminis strain Bac44 plasmid unnamed, complete sequence	483785-483839	11	0.8

1. spacer 11.60|2121400|35|NC_016023|CRISPRCasFinder,CRT matches to LT960610 (Bacillus phage SBSphiC genome assembly, complete genome: monopartite) position: , mismatch: 4, identity: 0.886

gaatacgacttcgcatgtactgcgttttccatcgc	CRISPR spacer
gaatatgacttcgcatgtacagcgttttccatcat	Protospacer
*****.************** ************..

2. spacer 11.84|2121401|35|NC_016023|PILER-CR matches to LT960610 (Bacillus phage SBSphiC genome assembly, complete genome: monopartite) position: , mismatch: 4, identity: 0.886

gaatacgacttcgcatgtactgcgttttccatcgc	CRISPR spacer
gaatatgacttcgcatgtacagcgttttccatcat	Protospacer
*****.************** ************..

3. spacer 2.8|321025|27|NC_016023|CRT matches to MK359332 (Streptomyces phage Genie2, complete genome) position: , mismatch: 5, identity: 0.815

cacgttacgtctggatccgaaatgtcc	CRISPR spacer
cgcgttacctctgcatccgaaatgtat	Protospacer
*.****** **** *********** .

4. spacer 2.8|321025|27|NC_016023|CRT matches to MK359351 (Streptomyces phage BoomerJR, complete genome) position: , mismatch: 5, identity: 0.815

cacgttacgtctggatccgaaatgtcc	CRISPR spacer
cgcgttacctctgcatccgaaatgtat	Protospacer
*.****** **** *********** .

5. spacer 2.8|321025|27|NC_016023|CRT matches to MH727564 (Streptomyces phage Yaboi, complete genome) position: , mismatch: 5, identity: 0.815

cacgttacgtctggatccgaaatgtcc	CRISPR spacer
cgcgttacctctgcatccgaaatgtat	Protospacer
*.****** **** *********** .

6. spacer 2.10|321129|27|NC_016023|CRT matches to MK359332 (Streptomyces phage Genie2, complete genome) position: , mismatch: 5, identity: 0.815

cacgttacgtctggatccgaaatgtcc	CRISPR spacer
cgcgttacctctgcatccgaaatgtat	Protospacer
*.****** **** *********** .

7. spacer 2.10|321129|27|NC_016023|CRT matches to MK359351 (Streptomyces phage BoomerJR, complete genome) position: , mismatch: 5, identity: 0.815

cacgttacgtctggatccgaaatgtcc	CRISPR spacer
cgcgttacctctgcatccgaaatgtat	Protospacer
*.****** **** *********** .

8. spacer 2.10|321129|27|NC_016023|CRT matches to MH727564 (Streptomyces phage Yaboi, complete genome) position: , mismatch: 5, identity: 0.815

cacgttacgtctggatccgaaatgtcc	CRISPR spacer
cgcgttacctctgcatccgaaatgtat	Protospacer
*.****** **** *********** .

9. spacer 11.21|2118798|35|NC_016023|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP026096 (Bacillus asahii strain OM18 plasmid pOM18, complete sequence) position: , mismatch: 5, identity: 0.857

ttttggggtgtgaggctggctgggggtgtgggggc-	CRISPR spacer
ttttgaggtgtgaggttggct-ggggtgtggggcta	Protospacer
*****.*********.***** *********** .

10. spacer 11.51|2120803|37|NC_016023|CRISPRCasFinder,CRT matches to MN693342 (Marine virus AFVG_25M9, complete genome) position: , mismatch: 6, identity: 0.838

ctgtctgtgc---tgcttgtgctgcatctgcagctgtagc	CRISPR spacer
---tttgtgcaggtgcttttgcagcatctgcagctgtagc	Protospacer
   *.*****   ***** *** *****************

11. spacer 11.75|2120804|37|NC_016023|PILER-CR matches to MN693342 (Marine virus AFVG_25M9, complete genome) position: , mismatch: 6, identity: 0.838

ctgtctgtgc---tgcttgtgctgcatctgcagctgtagc	CRISPR spacer
---tttgtgcaggtgcttttgcagcatctgcagctgtagc	Protospacer
   *.*****   ***** *** *****************

12. spacer 16.1|2614657|55|NC_016023|CRISPRCasFinder matches to NZ_LR134399 (Listeria monocytogenes strain NCTC7974 plasmid 2, complete sequence) position: , mismatch: 6, identity: 0.891

cctttgctgcgggtgtagtttagtggtaaaaccacagccttccaagctgttgtcg	CRISPR spacer
cttactatgcgggtgtagtttagtggtaaaactacagccttccaagctgttgtcg	Protospacer
*.* .  *************************.**********************

13. spacer 11.12|2118199|35|NC_016023|PILER-CR,CRISPRCasFinder,CRT matches to MF360958 (Salicola phage SCTP-2, complete genome) position: , mismatch: 7, identity: 0.8

tcattgaatatgataaaataaatga-attggatgtc	CRISPR spacer
tcattgaatatgatcaaaaaaatgatgttgtagat-	Protospacer
************** *** ****** .*** * .*

14. spacer 16.1|2614657|55|NC_016023|CRISPRCasFinder matches to NZ_CP015440 (Anoxybacillus amylolyticus strain DSM 15939 plasmid pDSM15939_2, complete sequence) position: , mismatch: 7, identity: 0.873

cctttgctgcgggtgtagtttagtggtaaaaccacagccttccaagctgttgtcg	CRISPR spacer
attattatgcgggtgtagtttagtggtaaaacctcagccttccaagctgatgtcg	Protospacer
 .* *  ************************** *************** *****

15. spacer 11.12|2118199|35|NC_016023|PILER-CR,CRISPRCasFinder,CRT matches to AP014323 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-U-MedDCM-OCT-S33-C38, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 8, identity: 0.771

--tcattgaatatgataaaataaatgaattggatgtc	CRISPR spacer
atttatt--atatgataaaataaaagaattagattct	Protospacer
  *.***  *************** *****.*** ..

16. spacer 11.51|2120803|37|NC_016023|CRISPRCasFinder,CRT matches to NZ_CP031220 (Arcobacter mytili LMG 24559 plasmid pAMYT, complete sequence) position: , mismatch: 8, identity: 0.784

ctgtctg-tgctgcttgtgctgcatctgcagctgtagc	CRISPR spacer
-catctgctgctgcttgtgctgcatttgccgctgtttg	Protospacer
 ..**** *****************.*** *****

17. spacer 11.75|2120804|37|NC_016023|PILER-CR matches to NZ_CP031220 (Arcobacter mytili LMG 24559 plasmid pAMYT, complete sequence) position: , mismatch: 8, identity: 0.784

ctgtctg-tgctgcttgtgctgcatctgcagctgtagc	CRISPR spacer
-catctgctgctgcttgtgctgcatttgccgctgtttg	Protospacer
 ..**** *****************.*** *****

18. spacer 16.1|2614657|55|NC_016023|CRISPRCasFinder matches to NZ_CP015439 (Anoxybacillus amylolyticus strain DSM 15939 plasmid pDSM15939_1, complete sequence) position: , mismatch: 8, identity: 0.855

cctttgctgcgggtgtagtttagtggtaaaaccacagccttccaagctgttgtcg	CRISPR spacer
tataatatgcgggtgtagtttagtggtaaaacctcagccttccaagctgatgtcg	Protospacer
. *    ************************** *************** *****

19. spacer 6.17|1097145|36|NC_016023|CRISPRCasFinder,CRT matches to NZ_CP013981 (Staphylococcus equorum strain KM1031 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.75

ggtacagcacaaaaaaattaataactggtcattttt	CRISPR spacer
gctaggttacgaaaaaattaataactgggcatttaa	Protospacer
* ** . .**.***************** *****

20. spacer 6.17|1097145|36|NC_016023|CRISPRCasFinder,CRT matches to NZ_CP013981 (Staphylococcus equorum strain KM1031 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.75

ggtacagcacaaaaaaattaataactggtcattttt	CRISPR spacer
gctaggttacgaaaaaattaataactgggcatttaa	Protospacer
* ** . .**.***************** *****

21. spacer 6.17|1097145|36|NC_016023|CRISPRCasFinder,CRT matches to NC_013348 (Staphylococcus aureus plasmid pSK156, complete sequence) position: , mismatch: 9, identity: 0.75

ggtacagcacaaaaaaattaataactggtcattttt	CRISPR spacer
gctaggttacgaaaaaattaataactgggcatttaa	Protospacer
* ** . .**.***************** *****

22. spacer 6.17|1097145|36|NC_016023|CRISPRCasFinder,CRT matches to NC_009130 (Staphylococcus sp. 693-2 plasmid pLEW6932, complete sequence) position: , mismatch: 9, identity: 0.75

ggtacagcacaaaaaaattaataactggtcattttt	CRISPR spacer
gctaggttacgaaaaaattaataactgggcatttaa	Protospacer
* ** . .**.***************** *****

23. spacer 6.17|1097145|36|NC_016023|CRISPRCasFinder,CRT matches to CP027495 (Staphylococcus aureus strain ST2594 isolate 004 plasmid unnamed10) position: , mismatch: 9, identity: 0.75

ggtacagcacaaaaaaattaataactggtcattttt	CRISPR spacer
gctaggttacgaaaaaattaataactgggcatttaa	Protospacer
* ** . .**.***************** *****

24. spacer 6.17|1097145|36|NC_016023|CRISPRCasFinder,CRT matches to MN693588 (Marine virus AFVG_25M366, complete genome) position: , mismatch: 9, identity: 0.75

ggtacagcacaaaaaaattaataactggtcattttt	CRISPR spacer
ggtacagcaccaaaaaatttataactaaaaaatcct	Protospacer
********** ******** ******..  * *..*

25. spacer 6.45|1097146|36|NC_016023|PILER-CR matches to NZ_CP013981 (Staphylococcus equorum strain KM1031 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.75

ggtacagcacaaaaaaattaataactggtcattttt	CRISPR spacer
gctaggttacgaaaaaattaataactgggcatttaa	Protospacer
* ** . .**.***************** *****

26. spacer 6.45|1097146|36|NC_016023|PILER-CR matches to NZ_CP013981 (Staphylococcus equorum strain KM1031 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.75

ggtacagcacaaaaaaattaataactggtcattttt	CRISPR spacer
gctaggttacgaaaaaattaataactgggcatttaa	Protospacer
* ** . .**.***************** *****

27. spacer 6.45|1097146|36|NC_016023|PILER-CR matches to NC_013348 (Staphylococcus aureus plasmid pSK156, complete sequence) position: , mismatch: 9, identity: 0.75

ggtacagcacaaaaaaattaataactggtcattttt	CRISPR spacer
gctaggttacgaaaaaattaataactgggcatttaa	Protospacer
* ** . .**.***************** *****

28. spacer 6.45|1097146|36|NC_016023|PILER-CR matches to NC_009130 (Staphylococcus sp. 693-2 plasmid pLEW6932, complete sequence) position: , mismatch: 9, identity: 0.75

ggtacagcacaaaaaaattaataactggtcattttt	CRISPR spacer
gctaggttacgaaaaaattaataactgggcatttaa	Protospacer
* ** . .**.***************** *****

29. spacer 6.45|1097146|36|NC_016023|PILER-CR matches to CP027495 (Staphylococcus aureus strain ST2594 isolate 004 plasmid unnamed10) position: , mismatch: 9, identity: 0.75

ggtacagcacaaaaaaattaataactggtcattttt	CRISPR spacer
gctaggttacgaaaaaattaataactgggcatttaa	Protospacer
* ** . .**.***************** *****

30. spacer 6.45|1097146|36|NC_016023|PILER-CR matches to MN693588 (Marine virus AFVG_25M366, complete genome) position: , mismatch: 9, identity: 0.75

ggtacagcacaaaaaaattaataactggtcattttt	CRISPR spacer
ggtacagcaccaaaaaatttataactaaaaaatcct	Protospacer
********** ******** ******..  * *..*

31. spacer 12.2|2123969|35|NC_016023|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP013710 (Clostridium botulinum strain F634 plasmid pRSJ2_3, complete sequence) position: , mismatch: 9, identity: 0.743

ataaaacaaaaacagtaaagaaaattgagaagcgt	CRISPR spacer
ataaaacaaaaatagcaaagaaaattataagatat	Protospacer
************.**.**********. .*....*

32. spacer 12.2|2123969|35|NC_016023|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP014152 (Clostridium botulinum strain BrDura plasmid pRSJ20_1, complete sequence) position: , mismatch: 9, identity: 0.743

ataaaacaaaaacagtaaagaaaattgagaagcgt	CRISPR spacer
ataaaacaaaaatagcaaagaaaattataagatat	Protospacer
************.**.**********. .*....*

33. spacer 16.1|2614657|55|NC_016023|CRISPRCasFinder matches to NZ_CP024037 (Bacillus aryabhattai strain K13 plasmid unnamed2) position: , mismatch: 9, identity: 0.836

cctttgctgcgggtgtagtttagtggtaaaaccacagccttccaagctgttgtcg	CRISPR spacer
taaaatatgcgggtgtagtttagtggtaaaacctcagccttccaagctgatgtcg	Protospacer
.      ************************** *************** *****

34. spacer 16.1|2614657|55|NC_016023|CRISPRCasFinder matches to NZ_CP026740 (Bacillus megaterium strain YC4-R4 plasmid unnamed4) position: , mismatch: 9, identity: 0.836

cctttgctgcgggtgtagtttagtggtaaaaccacagccttccaagctgttgtcg	CRISPR spacer
taaaatatgcgggtgtagtttagtggtaaaacctcagccttccaagctgatgtcg	Protospacer
.      ************************** *************** *****

35. spacer 16.1|2614657|55|NC_016023|CRISPRCasFinder matches to NZ_CP010587 (Bacillus megaterium Q3 plasmid p1, complete sequence) position: , mismatch: 9, identity: 0.836

cctttgctgcgggtgtagtttagtggtaaaaccacagccttccaagctgttgtcg	CRISPR spacer
taaaatatgcgggtgtagtttagtggtaaaacctcagccttccaagctgatgtcg	Protospacer
.      ************************** *************** *****

36. spacer 16.1|2614657|55|NC_016023|CRISPRCasFinder matches to NZ_CP023319 (Bacillus megaterium strain A plasmid p2, complete sequence) position: , mismatch: 9, identity: 0.836

cctttgctgcgggtgtagtttagtggtaaaaccacagccttccaagctgttgtcg	CRISPR spacer
taaaatatgcgggtgtagtttagtggtaaaacctcagccttccaagctgatgtcg	Protospacer
.      ************************** *************** *****

37. spacer 16.1|2614657|55|NC_016023|CRISPRCasFinder matches to NC_017139 (Bacillus megaterium WSH-002 plasmid WSH-002_p1, complete sequence) position: , mismatch: 9, identity: 0.836

cctttgctgcgggtgtagtttagtggtaaaaccacagccttccaagctgttgtcg	CRISPR spacer
taaaatatgcgggtgtagtttagtggtaaaacctcagccttccaagctgatgtcg	Protospacer
.      ************************** *************** *****

38. spacer 16.1|2614657|55|NC_016023|CRISPRCasFinder matches to NC_020451 (Vibrio coralliilyticus strain ATCC BAA-450 plasmid, complete sequence) position: , mismatch: 9, identity: 0.836

cctttgctgcgggtgtagtttagtggtaaaaccacagccttccaagctgttgtcg	CRISPR spacer
actaaaatgcgggtgtagtttagtggtaaaacctcagccttccaagctgatgatg	Protospacer
 **  . ************************** *************** ** .*

39. spacer 6.15|1097015|35|NC_016023|CRISPRCasFinder,CRT matches to NZ_CP046333 (Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3) position: , mismatch: 10, identity: 0.714

gcacgccacggaaaaacaggccatggcggaaatgc----	CRISPR spacer
cgacgtcacggaagaacaggccatggc----acgttacg	Protospacer
  ***.*******.*************    *.*.

40. spacer 6.15|1097015|35|NC_016023|CRISPRCasFinder,CRT matches to NC_007974 (Cupriavidus metallidurans CH34 megaplasmid, complete sequence) position: , mismatch: 10, identity: 0.714

gcacgccacggaaaaacaggccatggcggaaatgc----	CRISPR spacer
cgacgtcacggaagaacaggccatggc----acgttacg	Protospacer
  ***.*******.*************    *.*.

41. spacer 6.43|1097016|35|NC_016023|PILER-CR matches to NZ_CP046333 (Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3) position: , mismatch: 10, identity: 0.714

gcacgccacggaaaaacaggccatggcggaaatgc----	CRISPR spacer
cgacgtcacggaagaacaggccatggc----acgttacg	Protospacer
  ***.*******.*************    *.*.

42. spacer 6.43|1097016|35|NC_016023|PILER-CR matches to NC_007974 (Cupriavidus metallidurans CH34 megaplasmid, complete sequence) position: , mismatch: 10, identity: 0.714

gcacgccacggaaaaacaggccatggcggaaatgc----	CRISPR spacer
cgacgtcacggaagaacaggccatggc----acgttacg	Protospacer
  ***.*******.*************    *.*.

43. spacer 11.22|2118863|37|NC_016023|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP017105 (Rhizobium gallicum strain IE4872 plasmid pRgalIE4872d, complete sequence) position: , mismatch: 10, identity: 0.73

gcggtatgatggatggagcaagccgaccctcggagct	CRISPR spacer
ggagatcatcggacggagcaagcctaccctcggagct	Protospacer
* .*  .. .***.********** ************

44. spacer 16.1|2614657|55|NC_016023|CRISPRCasFinder matches to NC_048753 (Lactobacillus phage 3-521, complete genome) position: , mismatch: 10, identity: 0.818

cctttgctgcgggtgtagtttagtggtaaaaccacagccttccaagctgttgtcg	CRISPR spacer
tagttcacgcgggtatagtttagtggtaaaaccacagccttccaagctgtagatg	Protospacer
.  **  .******.*********************************** * .*

45. spacer 11.8|2117930|35|NC_016023|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP054621 (Azospirillum oryzae strain KACC 14407 plasmid unnamed6, complete sequence) position: , mismatch: 11, identity: 0.686

tctgacggtccgagggctgcccaacggcacaaagt	CRISPR spacer
gccattcgtccgagggctgcccaccggcaaaatcc	Protospacer
 *.. . **************** ***** **  .

46. spacer 16.1|2614657|55|NC_016023|CRISPRCasFinder matches to NZ_CP033045 (Bacillus foraminis strain Bac44 plasmid unnamed, complete sequence) position: , mismatch: 11, identity: 0.8

cctttgctgcgggtgtagtttagtggtaaaaccacagccttccaagctgttgtcg	CRISPR spacer
ttaaccatgcgggtgtagtttagtggtaaaacctcagccttccaagctgatgatg	Protospacer
..  .  ************************** *************** ** .*

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1091199 : 1162368

Bacillus_virus(27.27%)

transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014096360.1\|1091199_1092663_-\|transposase	transposase	NA	NA	NA	NA
WP_029143158.1\|1093115_1093700_-	TetR family transcriptional regulator	NA	NA	NA	NA
WP_014096362.1\|1093875_1094424_+	hypothetical protein	NA	NA	NA	NA
WP_014096364.1\|1098281_1099340_-	phosphotransferase family protein	NA	NA	NA	NA
WP_014096365.1\|1099382_1099787_-	acyl-CoA thioesterase	NA	NA	NA	NA
WP_014096366.1\|1100002_1100566_-	TetR family transcriptional regulator	NA	NA	NA	NA
WP_014096367.1\|1100634_1102248_-	long-chain fatty acid--CoA ligase	A0A2H4PQM9	Staphylococcus_phage	9.2e-38	28.6
WP_014096368.1\|1102318_1103092_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_014096369.1\|1103069_1104314_-	acyl-CoA dehydrogenase	NA	NA	NA	NA
WP_014096370.1\|1104501_1105521_-	STAS domain-containing protein	NA	NA	NA	NA
WP_014096371.1\|1105719_1106439_-	YebC/PmpR family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_014096372.1\|1106823_1107411_-	hypothetical protein	NA	NA	NA	NA
WP_014096373.1\|1107403_1108024_-	hypothetical protein	NA	NA	NA	NA
WP_014096374.1\|1108763_1109402_+	hypothetical protein	NA	NA	NA	NA
WP_026104535.1\|1109541_1110579_-	NAD(P)/FAD-dependent oxidoreductase	G3MA85	Bacillus_virus	5.6e-20	26.0
WP_014096376.1\|1110610_1111426_-	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	1.2e-17	28.2
WP_014096377.1\|1111754_1112717_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_014096378.1\|1112873_1113920_+	iron ABC transporter permease	NA	NA	NA	NA
WP_044051932.1\|1113958_1114945_+	iron ABC transporter permease	NA	NA	NA	NA
WP_013858187.1\|1115084_1115867_+	TSUP family transporter	NA	NA	NA	NA
WP_014096380.1\|1115960_1116302_+	multidrug efflux SMR transporter	NA	NA	NA	NA
WP_014096381.1\|1116301_1116616_+	multidrug efflux SMR transporter	NA	NA	NA	NA
WP_017550731.1\|1116629_1117646_-	EamA family transporter	NA	NA	NA	NA
WP_014096383.1\|1117702_1118200_-	thioesterase	NA	NA	NA	NA
WP_014096384.1\|1118332_1118596_-	hypothetical protein	NA	NA	NA	NA
WP_014096385.1\|1118592_1118829_-	hypothetical protein	NA	NA	NA	NA
WP_014096386.1\|1118830_1119760_-\|transposase	Rpn family recombination-promoting nuclease/putative transposase	NA	NA	NA	NA
WP_014096387.1\|1120028_1121114_+	glycosyltransferase	NA	NA	NA	NA
WP_014096388.1\|1121110_1121725_+	glycerol-3-phosphate acyltransferase	NA	NA	NA	NA
WP_014096389.1\|1122047_1123091_-	ribonucleotide-diphosphate reductase subunit beta	A0A059T7I4	Listeria_phage	7.6e-110	56.6
WP_014096390.1\|1123035_1123518_-	flavodoxin	A0A060AL80	Listeria_phage	6.2e-14	36.9
WP_014096391.1\|1123502_1125737_-	ribonucleoside-diphosphate reductase subunit alpha	A0A0Y0AS84	Bacillus_phage	1.0e-260	61.0
WP_158657222.1\|1125687_1125906_-	hypothetical protein	NA	NA	NA	NA
WP_014096394.1\|1127207_1127429_-	heavy-metal-associated domain-containing protein	NA	NA	NA	NA
WP_014096395.1\|1127450_1129394_-	cation-translocating P-type ATPase	E4ZFI9	Streptococcus_phage	2.3e-107	38.3
WP_014096396.1\|1129601_1130354_-	Crp/Fnr family transcriptional regulator	NA	NA	NA	NA
WP_014096397.1\|1130597_1131683_-	excinuclease ABC subunit C	NA	NA	NA	NA
WP_014096398.1\|1131679_1132141_-	flavodoxin	NA	NA	NA	NA
WP_014096399.1\|1132908_1133817_+	decarboxylating 6-phosphogluconate dehydrogenase	A0A1D8KGX1	Synechococcus_phage	6.7e-54	36.1
WP_014096400.1\|1133877_1134570_+	GntR family transcriptional regulator	NA	NA	NA	NA
WP_014096401.1\|1134720_1136277_+	gluconokinase	NA	NA	NA	NA
WP_014096403.1\|1136678_1138007_+	2-keto-3-deoxygluconate permease	NA	NA	NA	NA
WP_014096404.1\|1138100_1138820_-	trehalose operon repressor	NA	NA	NA	NA
WP_014096405.1\|1138860_1140537_-	alpha,alpha-phosphotrehalase	NA	NA	NA	NA
WP_014096406.1\|1140665_1142084_-	PTS system trehalose-specific EIIBC component	NA	NA	NA	NA
WP_014096407.1\|1142114_1142597_-	PTS glucose transporter subunit IIA	NA	NA	NA	NA
WP_014096408.1\|1143129_1144659_-	ABC transporter permease/substrate-binding protein	NA	NA	NA	NA
WP_014096409.1\|1144651_1145608_-	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	2.4e-25	33.6
WP_014096411.1\|1146627_1147605_-	D-glycerate dehydrogenase	M1NSB9	Streptococcus_phage	7.6e-19	28.2
WP_014096412.1\|1147767_1148226_+	hypothetical protein	NA	NA	NA	NA
WP_014096413.1\|1148355_1148694_+	DsrE family protein	NA	NA	NA	NA
WP_014096414.1\|1148930_1150109_-	acetyl-CoA C-acetyltransferase	NA	NA	NA	NA
WP_014096415.1\|1150556_1151972_-\|transposase	ISLre2 family transposase	NA	NA	NA	NA
WP_014096416.1\|1152115_1153300_+	hydroxymethylglutaryl-CoA synthase	NA	NA	NA	NA
WP_014096417.1\|1153367_1154777_-	group II intron reverse transcriptase/maturase	A0A0U4J920	Pseudomonas_phage	2.9e-35	30.2
WP_014096418.1\|1155487_1156777_-	hydroxymethylglutaryl-CoA reductase, degradative	NA	NA	NA	NA
WP_014095994.1\|1157154_1158570_-\|transposase	ISLre2 family transposase	NA	NA	NA	NA
WP_013858128.1\|1159222_1160533_-\|transposase	transposase family protein	NA	NA	NA	NA
WP_014096419.1\|1160682_1162368_+\|transposase	IS1634 family transposase	NA	NA	NA	NA

DBSCAN-SWA_2

1402590 : 1410653

Staphylococcus_phage(66.67%)

protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014096614.1\|1402590_1403214_-\|protease	spore protease YyaC	G3M9W0	Bacillus_virus	4.7e-22	38.5
WP_014096615.1\|1403428_1404340_+	mechanosensitive ion channel family protein	NA	NA	NA	NA
WP_013860891.1\|1404329_1404530_+	DUF951 domain-containing protein	NA	NA	NA	NA
WP_014096616.1\|1404690_1405791_+	redox-regulated ATPase YchF	NA	NA	NA	NA
WP_142010213.1\|1406112_1407234_+	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	2.9e-54	37.0
WP_014096618.1\|1407214_1407862_+	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	8.8e-40	44.8
WP_014096619.1\|1407879_1409073_+	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	7.1e-112	54.1
WP_014096620.1\|1409085_1409556_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	2.2e-40	55.9
WP_014096621.1\|1409809_1410097_+	30S ribosomal protein S6	NA	NA	NA	NA
WP_014096622.1\|1410158_1410653_+	single-stranded DNA-binding protein	A8ATZ7	Listeria_phage	2.8e-54	67.7

DBSCAN-SWA_3

1739213 : 1747526

Synechococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014096900.1\|1739213_1740509_+	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	6.5e-18	33.5
WP_014096901.1\|1740597_1741308_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	M4R1E8	Synechococcus_phage	1.6e-47	43.7
WP_013860601.1\|1741300_1741555_+	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_014096902.1\|1741551_1742235_+	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_014096903.1\|1742218_1744468_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	2.7e-168	44.2
WP_014096904.1\|1744452_1745877_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	6.0e-49	33.7
WP_014096905.1\|1745896_1746940_+	phosphoribosylformylglycinamidine cyclo-ligase	A0A0E3F760	Synechococcus_phage	6.5e-61	44.9
WP_014096906.1\|1746932_1747526_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	3.8e-29	40.3

DBSCAN-SWA_4

1879669 : 1950779

Enterococcus_phage(25.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014097019.1\|1879669_1881085_-\|transposase	ISLre2 family transposase	NA	NA	NA	NA
WP_014097020.1\|1881792_1882548_+	nickel pincer cofactor biosynthesis protein LarB	A0A288TYA6	Enterococcus_phage	1.8e-23	47.0
WP_014097021.1\|1882544_1883369_+	LarC family nickel insertion protein	NA	NA	NA	NA
WP_014097022.1\|1883373_1883844_+	DUF111 family protein	NA	NA	NA	NA
WP_014097025.1\|1884995_1886342_+	gluconate permease	NA	NA	NA	NA
WP_014097026.1\|1886883_1887693_+	ATP-dependent sacrificial sulfur transferase LarE	NA	NA	NA	NA
WP_014097027.1\|1887720_1889502_+	sigma-54-dependent Fis family transcriptional regulator	NA	NA	NA	NA
WP_014097028.1\|1889732_1891058_+	four-carbon acid sugar kinase family protein	NA	NA	NA	NA
WP_014097029.1\|1891127_1892132_+	4-hydroxythreonine-4-phosphate dehydrogenase PdxA	NA	NA	NA	NA
WP_014097030.1\|1892239_1893490_+	DUF2088 domain-containing protein	NA	NA	NA	NA
WP_014097031.1\|1893559_1894231_+	sulfite exporter TauE/SafE family protein	NA	NA	NA	NA
WP_014097032.1\|1894827_1896027_+	beta-ketoacyl synthase	NA	NA	NA	NA
WP_014097033.1\|1896050_1897481_+	HAMP domain-containing histidine kinase	NA	NA	NA	NA
WP_014097035.1\|1897938_1898268_+	hypothetical protein	NA	NA	NA	NA
WP_044051941.1\|1898516_1899971_-	PTS galactitol transporter subunit IIC	NA	NA	NA	NA
WP_014097037.1\|1900467_1901463_+	LacI family DNA-binding transcriptional regulator	C6ZCU4	Enterobacteria_phage	6.7e-31	33.6
WP_017552347.1\|1901681_1902401_+	ribulose-phosphate 3-epimerase	NA	NA	NA	NA
WP_014097039.1\|1902454_1903378_+	bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase	NA	NA	NA	NA
WP_014097040.1\|1903746_1905162_+\|transposase	ISLre2-like element ISBco6 family transposase	NA	NA	NA	NA
WP_014097041.1\|1905620_1907267_+	copper resistance protein CopC	NA	NA	NA	NA
WP_014097042.1\|1907435_1908050_+	DUF1775 domain-containing protein	NA	NA	NA	NA
WP_014097043.1\|1908429_1909419_+\|transposase	Rpn family recombination-promoting nuclease/putative transposase	NA	NA	NA	NA
WP_014097044.1\|1909420_1909684_+	hypothetical protein	NA	NA	NA	NA
WP_014097045.1\|1909882_1910371_+	pyridoxamine 5'-phosphate oxidase family protein	NA	NA	NA	NA
WP_014097046.1\|1910587_1911481_+\|transposase	Rpn family recombination-promoting nuclease/putative transposase	NA	NA	NA	NA
WP_035183435.1\|1912525_1913503_+	LacI family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_014097051.1\|1913505_1914387_+	ribokinase	NA	NA	NA	NA
WP_035183437.1\|1914386_1914779_+	D-ribose pyranase	NA	NA	NA	NA
WP_014097053.1\|1914825_1916325_+	sugar ABC transporter ATP-binding protein	W6JKT0	Anomala_cuprea_entomopoxvirus	1.1e-11	24.8
WP_014097054.1\|1916308_1917253_+	ribose ABC transporter permease	NA	NA	NA	NA
WP_013860507.1\|1917268_1918189_+	ribose ABC transporter substrate-binding protein RbsB	NA	NA	NA	NA
WP_003352379.1\|1918351_1918492_-	ribbon-helix-helix protein, CopG family	NA	NA	NA	NA
WP_014095882.1\|1918579_1919698_+	helix-turn-helix domain-containing protein	A0A288TXV8	Enterococcus_phage	8.3e-78	47.5
WP_014097055.1\|1920253_1921366_+	helix-turn-helix domain-containing protein	A0A288TXV8	Enterococcus_phage	1.1e-79	48.4
WP_041818033.1\|1921503_1922649_+	glycerate kinase	W6LM47	Streptococcus_phage	1.5e-45	38.4
WP_014097057.1\|1923169_1924219_+	2,3-butanediol dehydrogenase	NA	NA	NA	NA
WP_013860503.1\|1924356_1925436_+	PRK06851 family protein	NA	NA	NA	NA
WP_014097058.1\|1926157_1928029_+	anaerobic ribonucleoside triphosphate reductase	A0A2R2ZH54	Clostridioides_phage	2.1e-158	45.8
WP_014097059.1\|1928025_1928502_+	anaerobic ribonucleoside-triphosphate reductase activating protein	A0A0A8WJI9	Clostridium_phage	1.3e-37	50.3
WP_014097060.1\|1929109_1930366_+	cation:dicarboxylase symporter family transporter	NA	NA	NA	NA
WP_014097061.1\|1930662_1932192_+	type I restriction-modification system subunit M	A0A2H4PQP4	Staphylococcus_phage	8.9e-99	39.9
WP_014097062.1\|1932203_1933385_+	restriction endonuclease subunit S	NA	NA	NA	NA
WP_014097063.1\|1933429_1936537_+	type I restriction endonuclease subunit R	A0A220A398	Liberibacter_phage	7.2e-71	27.0
WP_014097064.1\|1936550_1937273_+	M48 family metallopeptidase	NA	NA	NA	NA
WP_014097065.1\|1937411_1938236_+	hypothetical protein	NA	NA	NA	NA
WP_014097066.1\|1938902_1939079_+	antitoxin VbhA family protein	NA	NA	NA	NA
WP_013860499.1\|1939611_1939980_+	helix-turn-helix transcriptional regulator	E4ZFI8	Streptococcus_phage	2.6e-49	77.0
WP_014097067.1\|1939972_1942108_+	cadmium-translocating P-type ATPase	E4ZFI9	Streptococcus_phage	0.0e+00	84.7
WP_014097069.1\|1943153_1943453_+	YqcI/YcgG family protein	NA	NA	NA	NA
WP_014097072.1\|1945587_1946577_-	LD-carboxypeptidase	NA	NA	NA	NA
WP_014097073.1\|1946799_1948104_-\|transposase	IS1380-like element ISBco2 family transposase	NA	NA	NA	NA
WP_014097075.1\|1949483_1950779_-\|transposase	transposase	NA	NA	NA	NA

DBSCAN-SWA_5

2800276 : 2859985

Staphylococcus_phage(16.67%)

coat,tRNA,transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014097792.1\|2800276_2801638_+\|transposase	transposase	NA	NA	NA	NA
WP_014097793.1\|2801639_2802065_+	hypothetical protein	NA	NA	NA	NA
WP_014097794.1\|2802091_2802304_-	small acid-soluble spore protein SspI	NA	NA	NA	NA
WP_014097795.1\|2802408_2803164_+	RNA methyltransferase	NA	NA	NA	NA
WP_014097797.1\|2803799_2804837_+\|tRNA	phenylalanine--tRNA ligase subunit alpha	A0A2I2L4E3	Orpheovirus	7.0e-31	33.1
WP_014097798.1\|2804849_2807264_+\|tRNA	phenylalanine--tRNA ligase subunit beta	NA	NA	NA	NA
WP_014097799.1\|2807656_2808592_-	ribonuclease HIII	NA	NA	NA	NA
WP_013859878.1\|2808692_2808983_+	cell division protein ZapA	NA	NA	NA	NA
WP_014097800.1\|2808969_2809506_+	CvpA family protein	NA	NA	NA	NA
WP_014097801.1\|2809784_2811503_+	DNA polymerase/3'-5' exonuclease PolX	A0A0N9R450	Chrysochromulina_ericina_virus	2.6e-14	26.2
WP_014097802.1\|2811578_2813933_+	endonuclease MutS2	Q94M10	Lactobacillus_phage	2.6e-20	49.6
WP_014097803.1\|2814169_2815867_+	AMP-binding protein	A0A2H4PQM9	Staphylococcus_phage	2.5e-41	27.7
WP_014097804.1\|2816009_2816603_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_014097805.1\|2816636_2817410_+	enoyl-CoA hydratase	NA	NA	NA	NA
WP_014097806.1\|2817472_2818246_+	electron transfer flavoprotein subunit beta/FixA family protein	NA	NA	NA	NA
WP_014097807.1\|2818276_2819257_+	electron transfer flavoprotein subunit alpha/FixB family protein	NA	NA	NA	NA
WP_014097808.1\|2819443_2819758_+	thioredoxin	A0A1X9I9P5	Staphylococcus_phage	2.6e-21	42.7
WP_014097809.1\|2819863_2821636_+	excinuclease ABC subunit UvrC	NA	NA	NA	NA
WP_014097810.1\|2822052_2823282_+	aspartate kinase	NA	NA	NA	NA
WP_014097811.1\|2823314_2823779_-	YslB family protein	NA	NA	NA	NA
WP_014097812.1\|2824207_2824816_+	succinate dehydrogenase cytochrome b558 subunit	NA	NA	NA	NA
WP_014097813.1\|2824887_2826639_+	succinate dehydrogenase flavoprotein subunit	NA	NA	NA	NA
WP_014097814.1\|2826711_2827479_+	succinate dehydrogenase iron-sulfur subunit	NA	NA	NA	NA
WP_043052492.1\|2827543_2828053_+	acyl-CoA thioesterase	NA	NA	NA	NA
WP_014097816.1\|2828412_2828637_+	response regulator transcription factor	A0A290GJH9	Caldibacillus_phage	6.1e-17	77.0
WP_035184465.1\|2828922_2829108_+	hypothetical protein	NA	NA	NA	NA
WP_014097817.1\|2829374_2829674_+	DUF1648 domain-containing protein	NA	NA	NA	NA
WP_014097818.1\|2829686_2830775_+	DUF2157 domain-containing protein	NA	NA	NA	NA
WP_014097819.1\|2830767_2831292_+	GDYXXLXY domain-containing protein	NA	NA	NA	NA
WP_035184469.1\|2831733_2832186_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_014097821.1\|2832196_2833006_+	glutamate racemase	NA	NA	NA	NA
WP_014097822.1\|2833096_2833312_+	hypothetical protein	NA	NA	NA	NA
WP_014097823.1\|2833308_2833677_+\|coat	spore coat protein	NA	NA	NA	NA
WP_014097824.1\|2833686_2834823_+	glutathione-dependent formaldehyde dehydrogenase	E3SJ82	Synechococcus_phage	3.2e-13	29.8
WP_014097825.1\|2834969_2835272_-\|coat	spore coat protein	NA	NA	NA	NA
WP_014097826.1\|2835268_2835469_-	hypothetical protein	NA	NA	NA	NA
WP_014097827.1\|2835612_2836653_+	GerMN domain-containing protein	NA	NA	NA	NA
WP_014097828.1\|2836760_2837369_+	XTP/dITP diphosphatase	A0A2H4UUV7	Bodo_saltans_virus	8.1e-11	33.3
WP_014097829.1\|2837365_2837875_+	metallophosphoesterase	NA	NA	NA	NA
WP_014097830.1\|2838678_2839080_+	hypothetical protein	NA	NA	NA	NA
WP_014097831.1\|2839318_2839615_-	hypothetical protein	NA	NA	NA	NA
WP_014097832.1\|2839749_2840193_+	YndM family protein	NA	NA	NA	NA
WP_014097833.1\|2840332_2841325_+	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_014097834.1\|2841488_2842775_+	trigger factor	NA	NA	NA	NA
WP_014097835.1\|2843143_2844412_+\|protease	ATP-dependent protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	5.4e-150	67.4
WP_014097836.1\|2844703_2846341_+\|protease	ATP-dependent protease LonB	A0A0R6PGP8	Moraxella_phage	2.9e-15	36.4
WP_014097837.1\|2846384_2848709_+	endopeptidase La	A0A0R6PGP8	Moraxella_phage	4.8e-181	44.5
WP_014097838.1\|2848705_2849290_+	YihA family ribosome biogenesis GTP-binding protein	NA	NA	NA	NA
WP_014097839.1\|2849466_2849961_-	hypothetical protein	NA	NA	NA	NA
WP_014097840.1\|2850146_2851478_+\|tRNA	glutamyl-tRNA reductase	NA	NA	NA	NA
WP_014097841.1\|2851493_2852318_+	cytochrome c biogenesis protein CcsA	NA	NA	NA	NA
WP_014097842.1\|2852330_2853263_+	hydroxymethylbilane synthase	NA	NA	NA	NA
WP_014097843.1\|2853259_2854048_+	uroporphyrinogen-III synthase	NA	NA	NA	NA
WP_014097844.1\|2854284_2855262_+	porphobilinogen synthase	NA	NA	NA	NA
WP_014097845.1\|2855277_2856567_+	glutamate-1-semialdehyde 2,1-aminomutase	A0A1V0SKB7	Klosneuvirus	4.4e-06	27.6
WP_014097846.1\|2856952_2858770_+	LysM peptidoglycan-binding domain-containing protein	NA	NA	NA	NA
WP_026104585.1\|2858968_2859985_+\|coat	spore coat protein YsxE	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_016023

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection