CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_017316	Enterococcus faecalis OG1RF, complete genome	3 crisprs	csa3,cas3,cas9,cas1,cas2,csn2,cas14j,DinG,DEDDh	0	14	4	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_017316_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017316_1

422486-422984

TypeII

II-A,II-B

Consensus_repeat	Method
GTTTTAGAGTCATGTTGTTTAGAATGGTACCAAAACT	CRISPRCasFinder
GTTTTAGAGTCATGTTGTTTAGAATGGTACCAAAACT	CRT
GTTTTAGAGTCATGTTGTTTAGAATGGTACCAAAAC	PILER-CR

7 spacers

csn2,cas2,cas1,cas9

The CRISPR arrays of NC_017316_1

>merge|NC_017316|1|422486-422984|CRISPRCasFinder,CRT,PILER-CR
GTTTTAGAGTCATGTTGTTTAGAATGGTACCAAAACTTTGCCACTTGCGAGCTTCACCAGAGCTATGTTTTAGAGTCATGTTGTTTAGAATGGTACCAAAACTAGGTTTCAAGTGTGAATAGGTACGGTCTTGTTTTAGAGTCATGTTGTTTAGAATGGTACCAAAACTATAAATTCTACCCCCATGTTATAAAACGGGTTTTAGAGTCATGTTGTTTAGAATGGTACCAAAACTTTAGGTAGTTTTTTAACGCACTTACTTCTGTTTTAGAGTCATGTTGTTTAGAATGGTACCAAAACTGCCGTCGGAACCGTCCCGACTTCCTAACAGTTTTAGAGTCATGTTGTTTAGAATGGTACCAAAACATTTTGAGACATGGTCGTTTCGTTTTGAATGTTTTAGAGTCATGTTGTTTAGAATGGTACCAAATCTCTAATGAGCATTCATTACATATGTAGAACGTTTTAGAGTCATGTTGTTTAGTTTTCGCAAATACGA

>NC_017316|1|1|422486-422984|CRISPRCasFinder
GTTTTAGAGTCATGTTGTTTAGAATGGTACCAAAACT	TTGCCACTTGCGAGCTTCACCAGAGCTAT
GTTTTAGAGTCATGTTGTTTAGAATGGTACCAAAACT	AGGTTTCAAGTGTGAATAGGTACGGTCTT
GTTTTAGAGTCATGTTGTTTAGAATGGTACCAAAACT	ATAAATTCTACCCCCATGTTATAAAACGG
GTTTTAGAGTCATGTTGTTTAGAATGGTACCAAAACT	TTAGGTAGTTTTTTAACGCACTTACTTCT
GTTTTAGAGTCATGTTGTTTAGAATGGTACCAAAACT	GCCGTCGGAACCGTCCCGACTTCCTAACA
GTTTTAGAGTCATGTTGTTTAGAATGGTACCAAAACA	TTTTGAGACATGGTCGTTTCGTTTTGAAT
GTTTTAGAGTCATGTTGTTTAGAATGGTACCAAATCT	CTAATGAGCATTCATTACATATGTAGAAC
GTTTTAGAGTCATGTTGTTTAGTTTTCGCAAATACGA

>NC_017316|1|1|422486-422984|CRT
GTTTTAGAGTCATGTTGTTTAGAATGGTACCAAAACT	TTGCCACTTGCGAGCTTCACCAGAGCTAT
GTTTTAGAGTCATGTTGTTTAGAATGGTACCAAAACT	AGGTTTCAAGTGTGAATAGGTACGGTCTT
GTTTTAGAGTCATGTTGTTTAGAATGGTACCAAAACT	ATAAATTCTACCCCCATGTTATAAAACGG
GTTTTAGAGTCATGTTGTTTAGAATGGTACCAAAACT	TTAGGTAGTTTTTTAACGCACTTACTTCT
GTTTTAGAGTCATGTTGTTTAGAATGGTACCAAAACT	GCCGTCGGAACCGTCCCGACTTCCTAACA
GTTTTAGAGTCATGTTGTTTAGAATGGTACCAAAACA	TTTTGAGACATGGTCGTTTCGTTTTGAAT
GTTTTAGAGTCATGTTGTTTAGAATGGTACCAAATCT	CTAATGAGCATTCATTACATATGTAGAAC
GTTTTAGAGTCATGTTGTTTAGTTTTCGCAAATACGA

>NC_017316|1|1|422684-422917|PILER-CR
GTTTTAGAGTCATGTTGTTTAGAATGGTACCAAAAC	TTTAGGTAGTTTTTTAACGCACTTACTTCT
GTTTTAGAGTCATGTTGTTTAGAATGGTACCAAAAC	TGCCGTCGGAACCGTCCCGACTTCCTAACA
GTTTTAGAGTCATGTTGTTTAGAATGGTACCAAAAC	ATTTTGAGACATGGTCGTTTCGTTTTGAAT
GTTTTAGAGTCATGTTGTTTAGAATGGTACCAAATC

Protein	Signature genes	Signature genes Name	Protein_function
NC_017316.1\|WP_002386140.1\|413353_414127_+\|rRNA-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|224108
NC_017316.1\|WP_002364833.1\|421403_421733_+\|CRISPR-associated-endonuclease-Cas2	cas2	COG3512_cas2_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|226043
NC_017316.1\|WP_002355504.1\|415820_416054_+\|hypothetical-protein	unknown	unknown	unknown
NC_017316.1\|WP_002355509.1\|427662_428118_+\|arginine-repressor	unknown	unknown	gnl\|CDD\|224355
NC_017316.1\|WP_002378005.1\|409904_411431_-\|UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L--lysine-ligase	unknown	unknown	gnl\|CDD\|237588
NC_017316.1\|WP_002355518.1\|433816_434158_+\|YlbF-family-regulator	unknown	unknown	gnl\|CDD\|237467
NC_017316.1\|WP_002375918.1\|426003_427521_+\|ABC-transporter-permease/substrate-binding-protein	unknown	unknown	gnl\|CDD\|270328
NC_017316.1\|WP_002413713.1\|428151_429660_+\|phosphoglucomutase	unknown	unknown	gnl\|CDD\|215211
NC_017316.1\|WP_002364837.1\|411634_413284_+\|polysaccharide-biosynthesis-protein	unknown	unknown	gnl\|CDD\|240529
NC_017316.1\|WP_002413712.1\|429683_430238_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|224584
NC_017316.1\|WP_014524952.1\|430361_431213_-\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638
NC_017316.1\|WP_002364832.1\|421733_422393_+\|type-II-A-CRISPR-associated-protein-Csn2	csn2	cd09758_csn2_CAS-II-A	gnl\|CDD\|213408
NC_017316.1\|WP_002413714.1\|425049_426000_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224050
NC_017316.1\|WP_002358653.1\|409265_409838_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223477
NC_017316.1\|WP_002364822.1\|434313_435549_+\|DNA-repair-exonuclease	unknown	unknown	gnl\|CDD\|277319
NC_017316.1\|WP_002355517.1\|431567_433754_+\|PBP1A-family-penicillin-binding-protein	unknown	unknown	gnl\|CDD\|273955
NC_017316.1\|WP_002358655.1\|414260_415676_+\|dipeptidase-PepV	unknown	unknown	gnl\|CDD\|130941
NC_017316.1\|WP_002381241.1\|423799_424813_-\|acyltransferase-family-protein	unknown	unknown	gnl\|CDD\|226122
NC_017316.1\|WP_002413717.1\|416526_420540_+\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	COG3513_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|226044
NC_017316.1\|WP_002364834.1\|420540_421407_+\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|187851

Protein	Function_ID	Function_description	E-value
NC_017316.1\|WP_002386140.1\|413353_414127_+\|rRNA-pseudouridine-synthase	gnl\|CDD\|224108	COG1187, RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis].	1.20502e-91
NC_017316.1\|WP_002364833.1\|421403_421733_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	1.08189e-44
NC_017316.1\|WP_002364837.1\|411634_413284_+\|polysaccharide-biosynthesis-protein	gnl\|CDD\|240529	cd13124, MATE_SpoVB_like, Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins. The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	2.27874e-136
NC_017316.1\|WP_002355509.1\|427662_428118_+\|arginine-repressor	gnl\|CDD\|224355	COG1438, ArgR, Arginine repressor [Transcription].	1.0984e-46
NC_017316.1\|WP_002378005.1\|409904_411431_-\|UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L--lysine-ligase	gnl\|CDD\|237588	PRK14022, PRK14022, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase.	0
NC_017316.1\|WP_002355518.1\|433816_434158_+\|YlbF-family-regulator	gnl\|CDD\|237467	PRK13676, PRK13676, YlbF/YmcA family competence regulator.	2.56028e-37
NC_017316.1\|WP_002375918.1\|426003_427521_+\|ABC-transporter-permease/substrate-binding-protein	gnl\|CDD\|270328	cd13610, PBP2_ChoS, Substrate-binding domain ChoS of an osmoregulated ABC-type transporter and related proteins; type 2 periplasmic-binding protein fold. Osmoprotectant binding lipoprotein ChoS of Lactococcus lactis is predicted to be involved in uptake of compatible solutes such as choline and glycine betaine, but the relative substrate preference is not known. To counteract the efflux of water, microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. ChoS belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	2.06182e-168
NC_017316.1\|WP_002413713.1\|428151_429660_+\|phosphoglucomutase	gnl\|CDD\|215211	PLN02371, PLN02371, phosphoglucosamine mutase family protein.	0
NC_017316.1\|WP_002413712.1\|429683_430238_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	2.16554e-26
NC_017316.1\|WP_014524952.1\|430361_431213_-\|RluA-family-pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	1.45104e-91
NC_017316.1\|WP_002364832.1\|421733_422393_+\|type-II-A-CRISPR-associated-protein-Csn2	gnl\|CDD\|213408	cd09758, Csn2, CRISPR/Cas system-associated protein Csn2. Csn2 is a Nmeni subtype-specific Cas protein, which may function in the adaptation process which mediates the incorporation of foreign nucleic acids into the microbial host genome. Csn 2 may interact directly with double-stranded DNA. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Csn2 has been predicted to be a functional analog of Cas4 based on anti-correlated phyletic patterns; also known as SPy1049 family.	3.31098e-118
NC_017316.1\|WP_002413714.1\|425049_426000_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224050	COG1125, OpuBA, ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism].	3.13184e-140
NC_017316.1\|WP_002358653.1\|409265_409838_+\|hypothetical-protein	gnl\|CDD\|223477	COG0400, COG0400, Predicted esterase [General function prediction only].	4.15912e-18
NC_017316.1\|WP_002364822.1\|434313_435549_+\|DNA-repair-exonuclease	gnl\|CDD\|277319	cd00840, MPP_Mre11_N, Mre11 nuclease, N-terminal metallophosphatase domain. Mre11 (also known as SbcD in Escherichia coli) is a subunit of the MRX protein complex. This complex includes: Mre11, Rad50, and Xrs2/Nbs1, and plays a vital role in several nuclear processes including DNA double-strand break repair, telomere length maintenance, cell cycle checkpoint control, and meiotic recombination, in eukaryotes. During double-strand break repair, the MRX complex is required to hold the two ends of a broken chromosome together. In vitro studies show that Mre11 has 3'-5' exonuclease activity on dsDNA templates and endonuclease activity on dsDNA and ssDNA templates. In addition to the N-terminal phosphatase domain, the eukaryotic MRE11 members of this family have a C-terminal DNA binding domain (not included in this alignment model). MRE11-like proteins are found in prokaryotes and archaea was well as in eukaryotes. Mre11 belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	1.06439e-49
NC_017316.1\|WP_002355517.1\|431567_433754_+\|PBP1A-family-penicillin-binding-protein	gnl\|CDD\|273955	TIGR02074, Includes:_Penicillin-insensitive_transglycosylase, penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	0
NC_017316.1\|WP_002358655.1\|414260_415676_+\|dipeptidase-PepV	gnl\|CDD\|130941	TIGR01886, Beta-Ala-Xaa_dipeptidase, dipeptidase PepV. This model represents a small clade of dipeptidase enzymes which are members of the larger M25 subfamily of metalloproteases. Two characterized enzymes are included in the seed. One, from Lactococcus lactis has been shown to act on a wide range of dipeptides, but not larger peptides. The enzyme from Lactobacillus delbrueckii was originally characterized as a Xaa-His dipeptidase, specifically a carnosinase (beta-Ala-His) by complementation of an E. coli mutant. Further study, including the crystallization of the enzyme, has shown it to also be a non-specific dipeptidase. This group also includes enzymes from Streptococcus and Enterococcus. [Protein fate, Degradation of proteins, peptides, and glycopeptides].	0
NC_017316.1\|WP_002381241.1\|423799_424813_-\|acyltransferase-family-protein	gnl\|CDD\|226122	COG3594, NolL, Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism].	2.63008e-11
NC_017316.1\|WP_002413717.1\|416526_420540_+\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	gnl\|CDD\|226044	COG3513, COG3513, Predicted CRISPR-associated nuclease, contains McrA/HNH-nuclease and RuvC-like nuclease domain [Defense mechanisms].	0
NC_017316.1\|WP_002364834.1\|420540_421407_+\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187851	cd09720, Cas1_II, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer intergration. Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	2.59266e-115

>NC_017316.1|WP_002364832.1|421733_422393_+|type-II-A-CRISPR-associated-protein-Csn2
MRVNFSLLEEPIEIEKATFLTIKDVQTFAHLVKLIYQYDGENELKLFDAQQKGLKPTELFVVTDILGYDVNSAATLKLIYGDLEAQLNDKPEVKSMIEKLTGTISQLIGYELLEHEMDLEEDGITVQELFKALGIKIETTSDTIFEKVMEITQVHRYLSKKKLLIFINACTYLTEDEVQQVVEYISLNNVDVLFLEQRVVQNRFQYILDENFYLSYEKA
>NC_017316.1|WP_002364833.1|421403_421733_+|CRISPR-associated-endonuclease-Cas2
MSYRYMRLLLMFDMPTDTASDRKAYRKFRKFLINEGFIMHQFSVYSKILLNDTANKAMLARLKQNNPQRGLITLLNVTEKQFSRMIYLHGEQDNRVANSDERIVFLGEE
>NC_017316.1|WP_002364834.1|420540_421407_+|type-II-CRISPR-associated-endonuclease-Cas1
MGWRTVVVNKHSKLSYKNNHLVFKAIDHQELIHLSEIDVLLLETTDISLTTMLLKRLIDEKILVLFCDDKRLPIGKILPFYGRHDSSLQLTRQLAWTEERKGQVWTAIIAQKITNQSLHLAQRDYGQKAAALLAMRAELRLFDPANREGHAARSYFNTLFGNDFTREQENDINAGLNYGYTLLLSIFARELVQTGCFTQLGLKHANQFNDFNLASDLMEPFRPLVDQIIYENRKEAFPIMKRKLFALFMNTYMYKKKQMFLTNIATDYTKHVVKVLNQEEEGVPEFGI
>NC_017316.1|WP_002413717.1|416526_420540_+|type-II-CRISPR-RNA-guided-endonuclease-Cas9
MKKDYVIGLDIGTNSVGWAVMTEDYQLVKKKMPIYGNTEKKKIKKNFWGVRLFEEGHTAEDRRLKRTARRRISRRRNRLRYLQAFFEEAMTDLDENFFARLQESFLVPEDKKWHRHPIFAKLEDEVAYHETYPTIYHLRKKLADSSEQADLRLIYLALAHIVKYRGHFLIEGKLSTENISVKEQFQQFMIIYNQTFVNGESRLVSAPLPESVLIEEELTEKASRTKKSEKVLQQFPQEKANGLFGQFLKLMVGNKADFKKVFGLEEEAKITYASESYEEDLEGILAKVGDEYSDVFLAAKNVYDAVELSTILADSDKKSHAKLSSSMIVRFTEHQEDLKKFKRFIRENCPDEYDNLFKNEQKDGYAGYIAHAGKVSQLKFYQYVKKIIQDIAGAEYFLEKIAQENFLRKQRTFDNGVIPHQIHLAELQAIIHRQAAYYPFLKENQEKIEQLVTFRIPYYVGPLSKGDASTFAWLKRQSEEPIRPWNLQETVDLDQSATAFIERMTNFDTYLPSEKVLPKHSLLYEKFMVFNELTKISYTDDRGIKANFSGKEKEKIFDYLFKTRRKVKKKDIIQFYRNEYNTEIVTLSGLEEDQFNASFSTYQDLLKCGLTRAELDHPDNAEKLEDIIKILTIFEDRQRIRTQLSTFKGQFSAEVLKKLERKHYTGWGRLSKKLINGIYDKESGKTILDYLVKDDGVSKHYNRNFMQLINDSQLSFKNAIQKAQSSEHEETLSETVNELAGSPAIKKGIYQSLKIVDELVAIMGYAPKRIVVEMARENQTTSTGKRRSIQRLKIVEKAMAEIGSNLLKEQPTTNEQLRDTRLFLYYMQNGKDMYTGDELSLHRLSHYDIDHIIPQSFMKDDSLDNLVLVGSTENRGKSDDVPSKEVVKDMKAYWEKLYAAGLISQRKFQRLTKGEQGGLTLEDKAHFIQRQLVETRQITKNVAGILNQRYNANSKEKKVQIITLKASLTSQFRSIFGLYKVREVNDYHHGQDAYLNCVVATTLLKVYPNLAPEFVYGEYPKFQTFKENKATAKAIIYTNLLRFFTEDEPRFTKDGEILWSNSYLKTIKKELNYHQMNIVKKVEVQKGGFSKESIKPKGPSNKLIPVKNGLDPQKYGGFDSPVVAYTVLFTHEKGKKPLIKQEILGITIMEKTRFEQNPILFLEEKGFLRPRVLMKLPKYTLYEFPEGRRRLLASAKEAQKGNQMVLPEHLLTLLYHAKQCLLPNQSESLAYVEQHQPEFQEILERVVDFAEVHTLAKSKVQQIVKLFEANQTADVKEIAASFIQLMQFNAMGAPSTFKFFQKDIERARYTSIKEIFDATIIYQSTTGLYETRRKVVD
>NC_017316.1|WP_002355504.1|415820_416054_+|hypothetical-protein
MSETLIVNYLIKGRVKMNVEELVQKAKDLIGEGNVEHAQQFIEEHKDELGEHYHKITAMLADTTTDGLFDKIKGLFQ
>NC_017316.1|WP_002358655.1|414260_415676_+|dipeptidase-PepV
MTIDWTKEVEARKDDLLEDLQNLLRINSERDDAQATPEAPFGPGPVAGLKHMLAYGERDGFTVKNVDNYAGHIEYGEGDETLGIFGHMDVVPAGDGWETDPYEPVIKDGKIYARGASDDKGPSMAAYYAMKIIKELGLPVSKKIRFVVGSDEESGWGDMDYYFQHEEAPDFGFSPDAEFPIINGEKGNVTIRLTFRGGNGADYKLESFKSGLRENMVPGTADAVVTAASADEAASLAASFETFIKQEAKISGNAELSDKTVTFHVVGKGAHGASPQSGINAATFLATFLNDYSFAEGAYSFINTIAEFIHEDFYGEKLGVAFEDEKMGKLTMNAGIVNFDPENPENSLVTLNFRYPKGTSAEELQAKVQATVGETVTATQGDRNQEPHYVPVDDPLVATLLQVYEDHTGEKGQEQIIGGGTYGRLLKRGVAYGAMFPGYTDTMHQANEFMELDDLFRAAAIYADAIYRLAK
>NC_017316.1|WP_002386140.1|413353_414127_+|rRNA-pseudouridine-synthase
MSQAIFLKERGMTMRLDKFLADVGIGSRKEIKQLLKKKVVTVNGDVVKEAKTQVNEETDQIALMGEILTYQKFFYYMLHKPQGVISATEDQRDETVIDLLTDQDYRADLFPVGRLDKDTEGLLLLTNDGQLAHQLLSPKKHVDKEYLAEVEGLVTAEDCQLFAQGFALKDGEIVKPSRLVIETINEEEGTSVVRLVIQEGKFHQVKRMLATVGKPVTYLKRLRMGELWLDETLELGGYRPLTEAELQQLQPKQSYLN
>NC_017316.1|WP_002364837.1|411634_413284_+|polysaccharide-biosynthesis-protein
MINQPNSVDQPILTNQEKMVKGSAWMTASNIISRMLGAIYIIPWYAWMGEHGNEANSLFSMGYTIYALFLMISTAGIPGAIAKQTSHYNSLNEYKISRQLFYRALQLMGGLGVVFAIVMYLASPALAALSGGGPELVPTMRSLSLAVLVFPSMSVIRGYFQGNQEMMPFALSQIVEQVARVFYMLLTAFIIMKVFEGNYVTAVTQATFAAFIGMLASFAVLGYYMYKQKPLFDYLEEHSANEHEIAPKELLIETFKEAIPFIVVGSGVTVFKLVDQFTFSNFMRLFTDYSDTQLRELFGIFNANPDKLTMIVVALATSISATGLPLITEAVTLKNHRELARLISNNLQLFVFVMLPATFGMIVLAQPLYTVFYMPDALGTSLLVQACYASLFLGLYMLVSNMLMGMYENRDAMRYLGIGLAVKLIVQFPAIRLFEVYGPLLATMIGFTVSCVLILRRIRQVTRFNYKLTLRRTLLMFCITVIMMIIALIFRQFLYLFLDPTRRFQAFIIVVIVAAAGGAFYGYSVLKIRLADRLLGKNAAKLRAKFNIK
>NC_017316.1|WP_002378005.1|409904_411431_-|UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L--lysine-ligase
MTISLFAIRDCLEKEDLLKEFISPEGWHLTLSDTLGQREVTALSYDSRDVTAETLFFCKGLNFKEIYLENAVKDGLEIYVSEVPYEVPAQLGIIVTDIKKAMAVLSMAFYDYPQNKLKLIGFTGTKGKTTAAYFTKYILDVATQQKTALLSTMNSTLDGKTFFKSALTTPESLDLYRMMATAVANGMTHFIMEVSSQAYKTNRVYKLFFDVGIFLNITPDHISPIEHPTFDDYFYCKRQLITHSKVIVLNHEADYFPLLKETAQQQKVPAIVYGSQPAPEVDYSFAVSSEDSLRFIVESPADALGLAGSYHLRLGGDFNKGNALSAAIASVLVGASKEECQQGIAATTVPGRMESLTNTNGATVYVDYAHNYDSLKNLLTFVREEHPDGRLIVLVGSTGDKAISRRKDFGRVLSELADVAVLTTDDPASEDPAKICQEIQAHITKEMPVYTILDRGEAIAHALSLSTTADDAIVLAGKGADLYQKVNGVDEPYAGDFALAEAFINKKN
>NC_017316.1|WP_002358653.1|409265_409838_+|hypothetical-protein
MKQFFQKGSKPNQLVVAFHGTGGNEYQLLTTIATLYPEASVLSYLGTEGVGEQRRFFAPLVNGALPRANFDERVTAFLEEVWQPQKLYDEVIFIGYSNGANFILGLLEKNPTIANTVILLHPSNLGYQYVSGEFATKVIVTTGAQDELSIPGQVLSLANQLKKHFPVDFLLVDGGHGLSEEEVTKIKEVL
>NC_017316.1|WP_002381241.1|423799_424813_-|acyltransferase-family-protein
MENDKRIYKWDNVKLFLIFLVIFGHILDREASPSRLMETINFWIYSFHMPAFIFVSGLFSKHAIKQRKYLRLLSFVWLYLLAKLLITLANFAFANKMNFDLLNETGVPWYLLSLASFYLITIFLQRVQPKIMLPIIIVIGCASGYLPVEGFLSLGRTLGFFPFFYCGYLMDIQKLQTFLDHRKVKWAAIGVILSSFLFVNSQWSLATKFWGFLTGWASYAEISPAFEYSSFIQLFFYVAAALVSLSWFALLPKRKLPLSALGKDTLYPYLLHMPLIILLESGLQLDTLFKEWFTFRILALFFLALFILAITNMPVVKRGADYLFNPQSIMIPKKIYK
>NC_017316.1|WP_002413714.1|425049_426000_+|ABC-transporter-ATP-binding-protein
MIKFQNVSKVYQENAVLSDVNLTIQQGEFFVLVGPSGSGKTTTLKMINRLIEPTTGEVALNEQAVTNYPLRELRLKIGYVLQQIALFPNLTVAENIELIPEMKKWPKEQRRERTIELLKKVQLDPEEYLHRKPAALSGGEQQRIGILRAIAAEPEVILMDEPFSALDPISRHHLQRLVKELHQELASTIVFVTHDMNEALLLGERICIMDAGKIIQVDTPEAIQKHPKNNFVGQFFKQSSPELANYCGADLTAFLEAADETIESVPTVFMETNLKEIVQLINAQEKANLVEKQQVLGCITSKTITRFMEQLLESEG
>NC_017316.1|WP_002375918.1|426003_427521_+|ABC-transporter-permease/substrate-binding-protein
MQALIETFFARKEEYLQALIEHMQLSFISLLFAALIAIPLAIYLTSHRKLAESLLQVTGIFQTIPSLALLGLLIPLIGIGRPPAIVALVIYALFPILQNTYTGLTEIDPSLEEAAEAFGMSKKEKLFKFELQMALPFIISGIRTATVLIIGTATLAALIGAGGLGTFILLGIDRNNLSLIFIGAISSAALAVLFNYGIHWLEKANGRRLIIGGTILGLLLGGSFFWNQQTSSKEKQLTIAGKLGAEPDIIINMYKALIEENSDIQVTLKPNFGKTTFLYNALKSDEIDLYPEFTGTVIETFLKNPPQLDNQPQVVYEAARAGLKKQENLTLLKPMRYENTYAVAVKRSFAKAHQLKTISDLQKISNQLKAGFTLEFIDRQDGYKGLQEKYHLNLNVQSMEPALRYQAINNGEVNVIDAYSTDSELRQYDLVTLEDDQALFPPYQGAPLIKTATLEKYPELAEILNKLAGKISEEEMSEMNYQVNVEGQDPSIVAKDYLKEKNLLK
>NC_017316.1|WP_002355509.1|427662_428118_+|arginine-repressor
MKKAERQRLIKQLIMQQEIETQDELITRLEELGVRATQATVSRDIREMSIVKTHGADGRVKYAIFSQAQGTSSEEKLRESVKDSVVRMERVQFIVILHTEMGNADVVSNFLDEVAYPEVAGTVAGADTIIVITRSEEDAEHFIERIENMIF
>NC_017316.1|WP_002413713.1|428151_429660_+|phosphoglucomutase
MVELKALQNGSDIRGIALDTEEQTATLTATAVAEIAVGVVRWLQDKKQLPRKAQQRLTIAIGHDSRLTAEPIKQALVDTFLSLGIQVIDVGLATTPAMFMATQFPTLQCDAAIMITASHLPYYFNGLKFFTAEGGAEKEDIRYILSHTDPLTANENGTLMKQELLPIYAEHLVAKIRQGIHSPEEKPLHGFRIIVDAGNGAGGFFAEQVLQVLGADTTGSQFLEPDGHFPNHVPNPDNSEAMKSIQTAVLANQADLGIIFDTDVDRSAVVDQSGEVLNRNNLIAVLAAIVLKEAPGSYIVTNSPTSSHLKTFIEEKGGQQIRYISGYRNVINKMIELNHGGFQTPLAIETSGHAAFQENYNLDDGAYVVAKILMLLPELKQNNQTLGDLIATLKQPAETNEFRFKITAEDVTCYGQQVLRDFELFVENQADFAVDRENQEGVRGNVSGQYGSGWFLLRLSLHEPLLVLQVENDQSDKNACVIEKIATFLQKYEEIDSQQIEK
>NC_017316.1|WP_002413712.1|429683_430238_+|GNAT-family-N-acetyltransferase
MENVLKGKHVGFSHFREEYIEHIAKQQWDNELLRHLSWDALHPWELEEWKDFTINKGEDDRFLFAILENTTEEFIGWVSLSDVQLKNRGANLGIAILQKEQRGQGYGFEAVSLICKFAFYELGLHKIRLAVNSNNQKAIHVYEKVGFKKEGIDREALFQDGQWLDIYNYGILQKEWLQMIKAES
>NC_017316.1|WP_014524952.1|430361_431213_-|RluA-family-pseudouridine-synthase
MRLPENFSTMTVKELLENEWLVPRKVRHFLRTRKNVKINGETAAFHFPVQAGDCVTLTFEETDYVRPTIHLGEATHVKVLYEDEHLMIVNKPYGIKTHPNQPQETNTLLNHVAAYLAEKNQVPYVVHRLDKETSGAIVFAKNPFVLPILGRLLETKQIYRQYQAIVAGHFNQKEQTINQPIGRDRHDRRKRRIDPQKGDSAITHVQVVKALSNNQTAVTCVLETGRTHQIRVHLASEGHPIIGDPLYNPKSQAARLMLHASQLHLLHPFTKKQIVVTAAPGLW
>NC_017316.1|WP_002355517.1|431567_433754_+|PBP1A-family-penicillin-binding-protein
MDNLKQFFSKVGVGLRHFWTWIKPYLIQFHQARKRIWKKYQINKIFLLIGLVVALGASIYLFYLAKSANVETLKSGLSESTRVYDESGEEVGKLFGQKGTFVELDNISPYIQDAVISTEDRGFYQHKGYSIKGIARAVVGKLTFGKIGGGGGGSTITQQLAKNAYLTQEQTLDRKARELFLAIEIEKKYSKKDILAMYLNNSYFGNGVWGVQDAARKYFGVDASQVTVGEAATLAGMLKGPGIYNPIDYIDNATARRNTVLQLMVDNKKLSQEEANQEASVNLASLLNDTYVGDENSYKYPYYFDAVIDEAVNRYKFKEEDILNKGYKIYTSLNQKYQDAMDATYKNDALFPPNAEDGAMVQSGSVAIDPKTGGVQALVGGRGEHVYRGFNFATQTKRSPGSSLKPISVYTPALEAGYKPDSVLEDKPQDYYPAQNYSRTYSGEVPMYQALGESLNLPAVWLLHQIGLDKGYEKTEKFGIPLSEKDRYYGLALGGLQTGVSPLTMAGAYSAFANEGYKTETHLITKIVDSTGAIVVDNTKVKKEQVITKDVADGITSMLLGVFSSGSGVNAQPAGYVMAGKTGTTETNFDSSKTNDQWVIGYTPEVVIATWLGFQETSKTHYLEGSSATYASQVFNSQASGILPQVKQAQFPVADAYATGGKVVDSNDSLTGGANSNWRDNLKDFGNSVQDGASNFGDTLNEVGGQIKDGAKKVKDKIEGIFGGLLGN
>NC_017316.1|WP_002355518.1|433816_434158_+|YlbF-family-regulator
MSNIYDTANQIERELRELDEFKALQAAYEEVKADEAAYTLFKEFQGFQQGLQEKQMRGEEFTDEDAEKAQSIATKVQETAVINELMQKEQAFSLVVNDLNRIIMTPVRDMYND
>NC_017316.1|WP_002364822.1|434313_435549_+|DNA-repair-exonuclease
MKLLHTADLHMDRSFEGLTGIPTALAKRLREANQQLLMNIVTVAIREAVDLVIFAGDTFHQSQTSISMQAQLMAALEQLKQAEIPVILTFGNHDYYKKDRYWFSFPDNVFLFEKEMVETLYFETKAGEQVAVSGFSYEHPWIDENKALEFPIKQAESDIHIGIYHGDTSRKAQQNYAPFTWKDLKATGYNYWALGHIHQPQIVSEQPLIVYPGTPQGHTKKEQSLQGVAVVTLSQNQATVQFEKVAEIDWTNEEVSLAQCRDTQSVLSYLETSLLTKWHAHQQQQLMALTLKETQHLDVTVVQAIVNGELLSYLQQQLLQKTQGDFFVYRLILQAEEPTKEPIYLSASPNLLTALEKTYLDPVIFEDTTKELLRYPEFAGIFSMDEQWRLESLRLAHEQINEDFTIQEDPL

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Crispr_ID: NC_017316_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017316_2

1738187-1738685

Orphan

II-A,II-B

Consensus_repeat	Method
AGTTTTGGTACCATTCTAAACAACATGACTCTAAAAC	CRISPRCasFinder
GTTTTGGTACCATTCTAAACAACATGACTCTAAAAC	CRT
GTTTTAGAGTCATGTTGTTTAGAATGGTACCAAAAC	PILER-CR

7 spacers

The CRISPR arrays of NC_017316_2

>merge|NC_017316|2|1738187-1738685|CRISPRCasFinder,CRT,PILER-CR
GGTGATAGTTTGTTTTTTAACAACATGGCTCTAAAACAAATTTTTTGAACTTAATGCAATTTCTTGAGTTTTGGTACCATTCTAAACAACATGACTCTAAAACAAAACTTTTGACGGCTCTTTAGTCAACCCAGTTTTGGTACCATTCTAAACAACATGACTCTAAAACGGAGAAATGTAGCTGCTGTTTTGACATTAGGTTTTGGTACCATTCTGAACAACATGACTCTAAAACTTCTATTCTTGCCTTTGCCTTTAAATTAGCGTTTTGGTACCATTCTAAACAACATGACTCTAAAACTGGTTGGATATTTTTCTAATAACTTACGGCGTTTTGGTACCATTCTAAACAACATGACTCTAAAACATGCAGACATTAAGAATTTACCAGAGGAAGGTTTTGGTACCATTCTAAACAACATGACTCTAAAACCTAGCATTTGTTAGATGGCACTACGATAAGGTTTTGGTACCATTCTAAACAACATGACTCTAAAAC

>NC_017316|2|2|1738187-1738685|CRISPRCasFinder
GGTGATAGTTTGTTTTTTAACAACATGGCTCTAAAAC	AAATTTTTTGAACTTAATGCAATTTCTTG
AGTTTTGGTACCATTCTAAACAACATGACTCTAAAAC	AAAACTTTTGACGGCTCTTTAGTCAACCC
AGTTTTGGTACCATTCTAAACAACATGACTCTAAAAC	GGAGAAATGTAGCTGCTGTTTTGACATTA
GGTTTTGGTACCATTCTGAACAACATGACTCTAAAAC	TTCTATTCTTGCCTTTGCCTTTAAATTAG
CGTTTTGGTACCATTCTAAACAACATGACTCTAAAAC	TGGTTGGATATTTTTCTAATAACTTACGG
CGTTTTGGTACCATTCTAAACAACATGACTCTAAAAC	ATGCAGACATTAAGAATTTACCAGAGGAA
GGTTTTGGTACCATTCTAAACAACATGACTCTAAAAC	CTAGCATTTGTTAGATGGCACTACGATAA
GGTTTTGGTACCATTCTAAACAACATGACTCTAAAAC

>NC_017316|2|2|1738188-1738685|CRT
GTGATAGTTTGTTTTTTAACAACATGGCTCTAAAAC	AAATTTTTTGAACTTAATGCAATTTCTTGA
GTTTTGGTACCATTCTAAACAACATGACTCTAAAAC	AAAACTTTTGACGGCTCTTTAGTCAACCCA
GTTTTGGTACCATTCTAAACAACATGACTCTAAAAC	GGAGAAATGTAGCTGCTGTTTTGACATTAG
GTTTTGGTACCATTCTGAACAACATGACTCTAAAAC	TTCTATTCTTGCCTTTGCCTTTAAATTAGC
GTTTTGGTACCATTCTAAACAACATGACTCTAAAAC	TGGTTGGATATTTTTCTAATAACTTACGGC
GTTTTGGTACCATTCTAAACAACATGACTCTAAAAC	ATGCAGACATTAAGAATTTACCAGAGGAAG
GTTTTGGTACCATTCTAAACAACATGACTCTAAAAC	CTAGCATTTGTTAGATGGCACTACGATAAG
GTTTTGGTACCATTCTAAACAACATGACTCTAAAAC

>NC_017316|2|2|1738254-1738685|PILER-CR
GTTTTGGTACCATTCTAAACAACATGACTCTAAAAC	AAAACTTTTGACGGCTCTTTAGTCAACCCA
GTTTTGGTACCATTCTAAACAACATGACTCTAAAAC	GGAGAAATGTAGCTGCTGTTTTGACATTAG
GTTTTGGTACCATTCTGAACAACATGACTCTAAAAC	TTCTATTCTTGCCTTTGCCTTTAAATTAGC
GTTTTGGTACCATTCTAAACAACATGACTCTAAAAC	TGGTTGGATATTTTTCTAATAACTTACGGC
GTTTTGGTACCATTCTAAACAACATGACTCTAAAAC	ATGCAGACATTAAGAATTTACCAGAGGAAG
GTTTTGGTACCATTCTAAACAACATGACTCTAAAAC	CTAGCATTTGTTAGATGGCACTACGATAAG
GTTTTGGTACCATTCTAAACAACATGACTCTAAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_017316.1\|WP_033591694.1\|1739790_1741872_-\|DNA-topoisomerase-III	unknown	unknown	gnl\|CDD\|236078
NC_017316.1\|WP_002356963.1\|1743167_1743683_+\|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein	unknown	unknown	gnl\|CDD\|176643
NC_017316.1\|WP_002356974.1\|1736362_1737781_-\|cytochrome-ubiquinol-oxidase-subunit-I	unknown	unknown	gnl\|CDD\|376587
NC_017316.1\|WP_002364369.1\|1733614_1735348_-\|thiol-reductant-ABC-exporter-subunit-CydD	unknown	unknown	gnl\|CDD\|274323
NC_017316.1\|WP_002360017.1\|1728524_1729736_-\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224172
NC_017316.1\|WP_049782621.1\|1744876_1745062_-\|hypothetical-protein	unknown	unknown	unknown
NC_017316.1\|WP_002360007.1\|1746880_1748026_-\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|224029
NC_017316.1\|WP_078127072.1\|1728316_1728448_-\|hypothetical-protein	unknown	unknown	unknown
NC_017316.1\|WP_002413381.1\|1742465_1743035_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379115
NC_017316.1\|WP_002356966.1\|1742002_1742368_-\|DUF1033-family-protein	unknown	unknown	gnl\|CDD\|336361
NC_017316.1\|WP_002356959.1\|1746468_1746813_-\|DUF1831-domain-containing-protein	unknown	unknown	gnl\|CDD\|370163
NC_017316.1\|WP_002364368.1\|1731851_1733618_-\|thiol-reductant-ABC-exporter-subunit-CydC	unknown	unknown	gnl\|CDD\|227320
NC_017316.1\|WP_002413384.1\|1738842_1739706_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NC_017316.1\|WP_002378476.1\|1730791_1731772_+\|polyprenyl-synthetase-family-protein	unknown	unknown	gnl\|CDD\|223220
NC_017316.1\|WP_002360016.1\|1729764_1730670_-\|prenyltransferase	unknown	unknown	gnl\|CDD\|235695
NC_017316.1\|WP_002369152.1\|1743699_1744932_+\|multidrug-efflux-MFS-transporter	unknown	unknown	gnl\|CDD\|340949
NC_017316.1\|WP_002362075.1\|1745118_1746243_-\|tRNA-2-thiouridine(34)-synthase-MnmA	unknown	unknown	gnl\|CDD\|234664
NC_017316.1\|WP_002413385.1\|1725786_1728210_-\|DNA-translocase-FtsK	unknown	unknown	gnl\|CDD\|224588
NC_017316.1\|WP_002356976.1\|1735352_1736366_-\|cytochrome-d-ubiquinol-oxidase-subunit-II	unknown	unknown	gnl\|CDD\|376764
NC_017316.1\|WP_011109517.1\|1737940_1738039_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_017316.1\|WP_033591694.1\|1739790_1741872_-\|DNA-topoisomerase-III	gnl\|CDD\|236078	PRK07726, PRK07726, DNA topoisomerase 3.	0
NC_017316.1\|WP_002356963.1\|1743167_1743683_+\|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein	gnl\|CDD\|176643	cd00865, PEBP_bact_arch, PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea. PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in bacterial and archaea. Members here include Escherichia coli YBHB and YBCL which are thought to regulate protein phosphorylation as well as Sulfolobus solfataricus SsCEI which inhibits serine proteases alpha-chymotrypsin and elastase. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer). In a few of the bacterial members present here the dimerization interface is proposed to form the ligand binding site, unlike in other PEBP members.	5.73504e-32
NC_017316.1\|WP_002356974.1\|1736362_1737781_-\|cytochrome-ubiquinol-oxidase-subunit-I	gnl\|CDD\|376587	pfam01654, Cyt_bd_oxida_I, Cytochrome bd terminal oxidase subunit I. This family are the alternative oxidases found in many bacteria which oxidize ubiquinol and reduce oxygen as part of the electron transport chain. This family is the subunit I of the oxidase E. coli has two copies of the oxidase, bo and bd', both of which are represented here In some nitrogen fixing bacteria, e.g. Klebsiella pneumoniae this oxidase is responsible for removing oxygen in microaerobic conditions, making the oxidase required for nitrogen fixation. This subunit binds a single b-haem, through ligands at His186 and Met393 (using SW:P11026 numbering). In addition His19 is a ligand for the haem b found in subunit II.	0
NC_017316.1\|WP_002364369.1\|1733614_1735348_-\|thiol-reductant-ABC-exporter-subunit-CydD	gnl\|CDD\|274323	TIGR02857, transport_ATP-binding_protein, thiol reductant ABC exporter, CydD subunit. The gene pair cydCD encodes an ABC-family transporter in which each gene contains an N-terminal membrane-spanning domain (pfam00664) and a C-terminal ATP-binding domain (pfam00005). In E. coli these genes were discovered as mutants which caused the terminal heme-copper oxidase complex cytochrome bd to fail to assemble. Recent work has shown that the transporter is involved in export of redox-active thiol compounds such as cysteine and glutathione. The linkage to assembly of the cytochrome bd complex is further supported by the conserved operon structure found outside the gammaproteobacteria (cydABCD) containing both the transporter and oxidase genes components. The genes used as the seed members for this model are all either found in the gammproteobacterial context or the CydABCD context. All members of this family scoring above trusted at the time of its creation were from genomes which encode a cytochrome bd complex. Unfortunately, the gene symbol nomenclature adopted based on this operon in B. subtilis assigns cydC to the third gene in the operon where this gene is actually homologous to the E. coli cydD gene. We have chosen to name all homologs in this family in accordance with the precedence of publication of the E. coli name, CydD.	0
NC_017316.1\|WP_002360017.1\|1728524_1729736_-\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224172	COG1252, Ndh, NADH dehydrogenase, FAD-containing subunit [Energy production and conversion].	1.24993e-121
NC_017316.1\|WP_002360007.1\|1746880_1748026_-\|cysteine-desulfurase	gnl\|CDD\|224029	COG1104, NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism].	5.37018e-179
NC_017316.1\|WP_002413381.1\|1742465_1743035_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|379115	pfam13305, WHG, WHG domain. This presumed domain is around 80 amino acids in length. It is found to the C-terminus of a DNA-binding helix-turn-helix domain. This domain may be involved in binding to an as yet unknown ligand that allows a transcriptional regulation response to that molecule. The domain is named WHG after three conserved residues near the C-terminus of the domain.	9.91237e-16
NC_017316.1\|WP_002356966.1\|1742002_1742368_-\|DUF1033-family-protein	gnl\|CDD\|336361	pfam06279, DUF1033, Protein of unknown function (DUF1033). This family consists of several hypothetical bacterial proteins. Many of the sequences in this family are annotated as putative DNA binding proteins but the function of this family is unknown.	4.62165e-64
NC_017316.1\|WP_002356959.1\|1746468_1746813_-\|DUF1831-domain-containing-protein	gnl\|CDD\|370163	pfam08866, DUF1831, Putative amino acid metabolism. Solution of the structure of the Lactobacillus plantarum protein from this family has indicated a potential new fold with remote similarities to TBP-like (TATA-binding protein) structures. This similarity, in combination with genomic context analysis, leads us to propose an involvement in amino-acid metabolism. The potentially novel fold is an alpha + beta fold comprising two beta sheets packed against a single helix. The enzyme is present in the cytosol.	1.33245e-53
NC_017316.1\|WP_002364368.1\|1731851_1733618_-\|thiol-reductant-ABC-exporter-subunit-CydC	gnl\|CDD\|227320	COG4987, CydC, ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones].	0
NC_017316.1\|WP_002413384.1\|1738842_1739706_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	4.87672e-27
NC_017316.1\|WP_002378476.1\|1730791_1731772_+\|polyprenyl-synthetase-family-protein	gnl\|CDD\|223220	COG0142, IspA, Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism].	4.36842e-80
NC_017316.1\|WP_002360016.1\|1729764_1730670_-\|prenyltransferase	gnl\|CDD\|235695	PRK06080, PRK06080, 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated.	8.82053e-105
NC_017316.1\|WP_002369152.1\|1743699_1744932_+\|multidrug-efflux-MFS-transporter	gnl\|CDD\|340949	cd17391, MFS_MdtG_MDR_like, Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.02154e-172
NC_017316.1\|WP_002362075.1\|1745118_1746243_-\|tRNA-2-thiouridine(34)-synthase-MnmA	gnl\|CDD\|234664	PRK00143, mnmA, tRNA-specific 2-thiouridylase MnmA; Reviewed.	0
NC_017316.1\|WP_002413385.1\|1725786_1728210_-\|DNA-translocase-FtsK	gnl\|CDD\|224588	COG1674, FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning].	5.98374e-175
NC_017316.1\|WP_002356976.1\|1735352_1736366_-\|cytochrome-d-ubiquinol-oxidase-subunit-II	gnl\|CDD\|376764	pfam02322, Cyt_bd_oxida_II, Cytochrome bd terminal oxidase subunit II. This family consists of cytochrome bd type terminal oxidases that catalyze quinol-dependent, Na+-independent oxygen uptake. Members of this family are integral membrane proteins and contain a protohaem IX centre B558. One member of the family, Klebsiella pneumoniae CydB, is implicated in having an important role in micro-aerobic nitrogen fixation in the enteric bacterium Klebsiella pneumoniae. The family forms an integral functional unit with subunit I, family Bac_Ubq_Cox, pfam01654.	9.60464e-103

>NC_017316.1|WP_011109517.1|1737940_1738039_-|hypothetical-protein
MIEEREEILVAPKKIVRNASVLFGFCLRKLYT
>NC_017316.1|WP_002356974.1|1736362_1737781_-|cytochrome-ubiquinol-oxidase-subunit-I
MFDIVTLARIQFAMTTVFHFFFVPFSIGLALVVAIMETMYVVKKEERYRKMAKFWGNIFLLSFAVGVVTGIIQEFQFGMNWSDYSRFVGDIFGAPLAVEALLAFFLESTFLGLWIFTWDKMNPKVHVTFIWLVVFGSMMSAFWILVANSFMQHPVGYVINNGRAEMVDFVAVISNPKVWYEFSHVIMGAFTLGGMAVAGMAAFQLLKKRDISFHKASMRIGLWVTLFGSIGVLLAGDLQMKALIEGQPMKFAAMEGAYEDSDDPAAWTLIAWADEREHKQVFGIDIPYMLSILSYNKLSGSVDGMDTVNKRLVEKYGDDKNYYPPVNTLFWSFRIMAGFGALMLLVAALGLFFTRKKKPSLYEKKWMLWIVALCTFAPFLANTTGWLVTELGRYPWTVYGLFTIEQSVSPNVSVASLITSNVIYFLLFAGLGSVMVYLVILELRKGPDYEAKKLAKENEPALDPFDKGVFGE
>NC_017316.1|WP_002356976.1|1735352_1736366_-|cytochrome-d-ubiquinol-oxidase-subunit-II
MSTLQLLWFVLIGVLFSGFFFLEGFDFGVGMAVQTLAHNDDEKDQVVATIGPVWDGNEVWLLTAGGAMFASFPYWYASLFSGYYLILFTILFGLIIRGVSFEFRHNMPEGKRRRMWNWTLSIGSFLVPFFFGILFISLVQGMPLDANGNMHAQFTDYFNLFSIVGGVALTLLCYLHGMNYIALKTEGPIRERARNYAEILYGVLYVGLVVFAVLMYFKTDFYEKNFAVTLILTLAIVVLTVIANVGVFKRKEMLAFLASGLTLVVLVALLFSGLFPRVMIGSEGFDLLIKDATSTPYTLKIMTWISLSILPFVLAYTAWSYYIFRKRISQTAVPEGY
>NC_017316.1|WP_002364369.1|1733614_1735348_-|thiol-reductant-ABC-exporter-subunit-CydD
MIDKDILQMPKIKKILVLLAGFSFLQAVFIIGQAFFLSKAIVGLWSGGHLNQQLQSILLFFIFYLGRHVITYFRERMLDTFSYERSKELREQLLTKIFRLGPNVVQKNGTGNMVTMALEGISQTENYLQLILTKMMNMMIIPWIILAFVFTQDIRSGVTLLIVFPIIIIFMIVLGYAAQSKADKQYAAFQMLSNHFIDSLRGIDTLKLFGLSKKYAGSIYHTSERFRKATMSTLKIAILSTFALDFFTTLSVAVVAVFLGLSLLNGTILLFPALVTLILAPEFFLPIRDFSSDYHATLDGKNSFQAIQAVLALPEAEQTDVLTLDDWHQESQLSVTALNFSYEDATQEAIQSLQFSVDGRKKIGIIGASGSGKSTLINLLSGFLLPTEETSQLAINGQTIPHFLQKDWQKQILYIPQAPYIFQDTLANNIRFYTPEATDEAIQQAIQLVGLDELVKDLPEGIHTLIGESGRMLSGGQAQRVALARAFVDQKRHVLLFDEPTAHLDIETEVEMKERMLPLMNNHLVFFATHRLHWMEEMDYILVMEKGQLVEQGTLAELIEKDGYYVQLMKQMRGGRQ
>NC_017316.1|WP_002364368.1|1731851_1733618_-|thiol-reductant-ABC-exporter-subunit-CydC
MMEKQPTTKDVWKNDQWVRPFLKRYKKTLYFALLLGFLTFFSAGALMFTSGYLISRAASLPENILLIYIPIVLTRAFGIGRPVFRYVERLTSHNWVLKMTSDLRLKLYNVLEKDAIFFKTKYRTGDILGLLSEDINHIQNLYLRTIFPTVIAWILYIFLVIALGFFSWWFALCMLLMLGVVVFLLPLVSVLVNGARQEKHKYAKNELYQTLTDNILGVSDWVFSQRGSEFVARYETDEANVRALDEKMKQFNRGRDFVLQLLFGVIAIAVLAWTSVRFPGNHGGAANWIGAFVLTVFPLIDAFAPLPAAAQETTIYKDSIRRFNELPEGEDDSTEAPVQPNGTSLSIEHLSFAYENQAKKVLNDLSLTIPEKQKLAILGRSGSGKSTLASLIRGDLRPTSGEILLGNIPTEAFGETMTEYIGVMHQAPYLFRTTILNNIRIGREEASEAEVWAVLEKVGLKEMVTQLPEGLQTMVDEAGLRFSGGERHRLALARILLQDTPIVLLDEPTTGLDPITEQQLLETFFEALKDKTVIWITHHLQGVTLMDQVIFIEDGQLEMSGTPEELLATNAHYQKLYRIDRGISSFEE
>NC_017316.1|WP_002378476.1|1730791_1731772_+|polyprenyl-synthetase-family-protein
MNTFWKSFPDVERSLTETCELIEQTLHTRNEDIEEALVTLARSGGKLLRPAFFFLFAQLGDEEKQEKQQLLKIAASLEILHMATLIHDDIIDDSPLRRGAVTIQSQYGKDVAVYTGDLLFTEFFTLIADAMNGSEFMKINAQGMKRLLLGELDQMSHRFDRRMSIPAYLRSVNGKTAELFSLSCLEGAYFGHSSKEVQRLAKRIGRHIGIAFQVYDDILDYTADTETLKKPALEDLSQGVYTLPLLFAYQAAPDVFGPYLDKGRAITLEEAAEVAALVNDYHGVTEAQAFAKKVTNKAITDIQQLPDGTAKETLLSLTELLLHRSF
>NC_017316.1|WP_002360016.1|1729764_1730670_-|prenyltransferase
MNREIFFELVELKAKTASVLPFLLGICFSWYQYGRLHVGYVLIFFIAMFIFNMAVDILDNYNDYHHATEVHDYKEKTNIIGRENLSLPLIRKMIFWMILVSALMGIGLSFIVGWPLLIMGLYCYLIGIFYSSGPKPLSSLPLGEVFSGFTMGFMITLICVYINTFEVFNWSAANLWGIFLVALPNTCYIANLMLANNICDLEEDENNKRYTLVHYLGKASSLKLFVGLNTIAMLAILLAVGLGLTPPTMLLMLLTLPFVRKQTQALLKEQVKSKTFVCAVKILAVGATAQVLFFAIGLWWL
>NC_017316.1|WP_002360017.1|1728524_1729736_-|NAD(P)/FAD-dependent-oxidoreductase
MNKKHVVILGAGYAGLKTLRELQKGAKDVEITLVDRNNYHYEATDLHEVAAGTQPAEKITYNIMDVVDEKMTTFIQGTVKTIDAATQTVALEDGQTINYDYLVVSLGFESESFGIPGVQEHALQMVDVKTALNVYEHIQEQMRQYKATQNEEFLKIVVCGAGFTGIELLGSLVENKPKFAEIAGVSADQIQIYCVEAVTRLLPMFNEKLANYGVQLLKDSAIHLLLGKPIKEIKPGAVVYQDNEAGDLAELSAKTIIWTTGVSGSHVVGDSGFEARRGRVMVQPDLTDANHSNVYIIGDCSAVMDTETNRPYPTTAQIALKMGAHAAKNIQAQLKGEATKPFSFKSQGSVCSVGNTRALGIVGKTDIKGYPASFMKKIIMNKALFETGGTKEMMAKGRFDLYH
>NC_017316.1|WP_078127072.1|1728316_1728448_-|hypothetical-protein
MLFNFWRISDYFRRSWFCSRRLSVFERGAKIQSDFCPTLIFLK
>NC_017316.1|WP_002413385.1|1725786_1728210_-|DNA-translocase-FtsK
MAQKRATNKKKSTTKKKTKKQQQQQERLNYMFLGLIFILFGVFGLFRLGFLGTLLANCLRLVVGNTFPFAAILLILYGLLVMIYGKDFPLKRGRPIFGAVLIYISVLLFFHAFMFRNVSGSQPDILGNTWEFLQSDLKANQVTQNVGGGMIGALLYQGTYFLVAQFGSYLIATLLLLAGIFLMSMWDFQQIVDHFQSIQDRLSHVSAKSQARQEEKEAKRAAKKEAKAVERQAKIEAAAQQKLQERERMEQAAAERLTKTPVETHQPMVEEPAAPTPVQIDSFQQQNQAMPVPPIAATKPQREQEEEATDEAGVLEFEISEEAEDRDYQLPPTDLLDTIQATDQSGEYEKIEKNIGVLEQTFKSFGVDAKVVKASLGPSVTKFEVQPAVGVKVSKIVNLTDDIALALAAKDVRMEAPIPGKSLIGIEVPNSAISTVSFRDIVEAQPSHPDKLLEVPLGRDISGMVQTADLSKMPHLLIAGSTGSGKSVAINGIITGILMQAKPHEVKLMMIDPKMVELNVYNGIPHLLTPVVTNPRKAAQALQKVVQEMEFRYEKFAATGVRNITGYNQLIQQKNAEDGENRPILPFIVVIVDELADLMMVASNEVEDAIIRLAQMARAAGIHMILATQRPSVDVITGIIKANVPSRMAFAVSSGTDSRTIIDTNGAEKLLGRGDMLFLPMGENKPIRIQGAFISDQEVERVVAFVTDQQEAEYQESMMPTDEPTTSGGGEAPQDELFEEAKNLVVEMQTASISLLQRRFRIGYNRAARLVDELEAHGVIGPSEGSKPRKVFLQAESEEAAPETPEQ
>NC_017316.1|WP_002413384.1|1738842_1739706_-|AraC-family-transcriptional-regulator
MLANLNQAMDYIEEHLTEEVSFDELAKKTGISVYHFKRTFSFIAGMSLAEYIKKRRLAEANLALLAGEKVTDVAFKYGYQSIEGFSRAFRDWTGQAPSEVMKTQIQKTFPKFSFYIDIKGGQSMDVKLIEKPAFQIVGVSQKVPLQYQGENQAIMELAQRITPQQRAEMHTFDDVYPHQVVNVSFDFQEGRTTEGGEMTHMIGFATSQENTYEDLEQLSVPAHTWAVFPNEGPFPQTLQETWARIFSEWLPSSGYQVVAAPEISFTQYQGPAEAKYSEIWLAVTATK
>NC_017316.1|WP_033591694.1|1739790_1741872_-|DNA-topoisomerase-III
MVAKQLIIAEKPSVAKDLSRVLGANQKNKNYYEGPNVIVTWALGHLLGLKMPEDLNKEWQTWQMETLPMIPKNLGIKPLPKTGHQLKAIKQLANRKDVSEAVIATDAGREGELVARWILEYVRFNKPVKRLWISSQTDKAIKDGFKKIRPAKDYDNLYYSALARAKADWLVGLNVTRALTVKYQDNLSAGRVQTPTLAMVRQQEKRIEQFKPQTYFTISLTVESEKAKMTQKNPYALKERQEAEQLVKELSKQKGLVTDIQEKVKTENAPLPYDLTEIQREANQRFQFSAKKTLSLVQSLYETHKIVSYPRTDSKYLTTDMKGTMKERLQAIADFSPEVKGYLKNGAVVKQQKVFQNAKVTDHHGLIPTEQRPRYEKLSNDEQKIYQMIVQRFLGLFAEPNQTKQTKVTVAFGKETFVFHQNKVVVAGWKTTAEQPLSIVQWQKGMTVAPNFTINKELTSPPKPLTEGTLLGKMEKHSLGTPATRAEIIEKLIKSELMERTNSGLSVSAKGKQLLDLVNPSLVTPELTEKWEKSLEAIASGQQKSQLFLKDIEEDTKKLVREIKQSEKKYQDFSITQKKCPDCGSNLREKNTKDGKIYVCTNQECSYRRRKDPKVSNHRCPQCHKKMVIIEGKNGRSFKCKFCSITEKIPDKKERKQKMTKHEERRLMKKYSQPDEPEESALAQALKAAMNQE
>NC_017316.1|WP_002356966.1|1742002_1742368_-|DUF1033-family-protein
MYQVITMYGDNEPWWFFDDWQEDIVQEKTFDNLTDAETYYVEVWQKLSQNYTYVNTKPNYLTAFWNDGEERWCEECDEDLQQYFGLALLENHHAVTFENKAEFTTISNHFGKTKFCKRKVI
>NC_017316.1|WP_002413381.1|1742465_1743035_-|TetR/AcrR-family-transcriptional-regulator
MAKKRNLTKAKILESARNLAEELGVQQLTFQNLAVDLGIKYPSLYNHFKNIAEVKNALVDLLIQELNDALRRALVGKSGAEAIRIYAEAYQQFAFENSAVYELLISVPKTQNQQLIEGIHETNQIILQLLAFYPFNNEERLHKSRELRSLIHGYITLRFLGYFQREEATPEESYRRMIEDFIASLEVAG
>NC_017316.1|WP_002356963.1|1743167_1743683_+|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein
MHITNRSHLADRYGKRTSAEFLLHERPILSFPISLAAIPKEARYLSWELIDYDTIPLIGFPFIHWLAANVPVTNEIPEDFSRTALKPTIQGKNSLASPLGKQMIPALATETLPELTERYLGLSPRSGVHTYTLYVYATKNPLNLKEGFFANELHQALNDQLLAKAKFEFLY
>NC_017316.1|WP_002369152.1|1743699_1744932_+|multidrug-efflux-MFS-transporter
MYELIKSKIFRPRQPWEKNLLVLWFGTFMAGIGFSLVMPFMPLYINTLGTFTHQQLNFWSGITFSSTFLVTTIVSPWWGRLADRKGRKLMLLRASLGMAIVISLMGAVTSVYQLIGLRLLQGVFSGYISNATALVATGTPKEKSGQVLGTLATGSVTGTLLGPLLGGVTASIFGYRPTFFITGTILLLVFVLSLVFVHEEFVPIEKNQAASGKQILKKLEHPHVILGMFITTLIIQASNNSISPIISLYIQQLLGGHGNVTLISGVIASIPGIATLIAAPRFGRLGDRIGSERILTIGLILAIFVYLPMAFVQNVWQLAMLRFLVGISDACLLPAVQTLITRYSPSDAAGRIFSYNQSFQATGNVIGPMIGSSVSAAFGYRGVFISTSCLVLLNLLWVRRSTAELKKREK
>NC_017316.1|WP_049782621.1|1744876_1745062_-|hypothetical-protein
MLVVKPVNIRFSFLFYMPIFFKIRKREKLKIQIVDNFSVYNLVIIFLFFLIRRCFDEPIEG
>NC_017316.1|WP_002362075.1|1745118_1746243_-|tRNA-2-thiouridine(34)-synthase-MnmA
MADNSKTRVVVGMSGGVDSSVTALLLKEQGYDVIGIFMKNWDDTDENGVCTATEDYKDVAKVADQIGIPYYSVNFEKEYWDRVFEYFLAEYRLGRTPNPDVMCNKEIKFKAFLDYAMQLGADYVATGHYAQVETDENGVVHMLRGIDNNKDQTYFLSQLSQAQLAKTMFPLGGMEKSEVRAIAERAGLATAKKKDSTGVCFIGEKNFKEFLSNYLPAKKGNMVTEDGEIKGQHDGLMYYTIGQRQGLGIGGGGKTQEPWFVIGKDLTTNTLYVGQGFHHEKLYATHLEASEVHFTVDTPMPKEFDCTAKFRYRQADIPVHVSLSEDGTKATVTFKEPARAVTPGQAVVFYDGMECLGGGLIDRAYQDEKELQYV
>NC_017316.1|WP_002356959.1|1746468_1746813_-|DUF1831-domain-containing-protein
MAFTTTAAVEGSTVFYKVHPSAKRYTLKDNGFTETKSGNFQLIRSLDPTPQRNEGFKLKITITADLKELKMSITTANGLKPMNIFKNEQHEMSKEKYFFLMDGLISRGVLEKVE
>NC_017316.1|WP_002360007.1|1746880_1748026_-|cysteine-desulfurase
MEPIYLDHAATTPLHPTVIQAMTENMQTTFGNPSSIHQFGRKAHGLLEEVRQTIAESLQAKPHEIIFNSGGTEGDNTAILAVAFSRQKEGKHIITTAIEHPAVLRTMEYLETLGFEVTYLPVNENGQISMDQFKKSLREETILVSMMYGNNEIGNRLPIAEVGAILKNHSAIFHTDAVQAYGSEVILPHELGIDLLSISAHKINGPKGVGFLFKSDAIQLPPLLHGGEQEEKRRAGTENLAGIIGMGTAVSLLTSAEKQARKTAYQSFQTIILKALEEANIDFSINGEPTNRLAHVLNLHLKGIPSDLLLMHLDLRGIAISTGSACTAGTVDPSHVLTAMYGENSSAIKESIRISFGYGNTPEEIATFSEVLVAVIQQLKK

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Crispr_ID: NC_017316_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017316_3

2561542-2561615

Orphan

Consensus_repeat	Method
ATAGTTGGCGAGCAACAGAAAAAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017316_3

>merge|NC_017316|3|2561542-2561615|CRISPRCasFinder
ATAGTTGGCGAGCAACAGAAAAACTCGATATAGAATTGGACGTAGAGCCAATAGTTGGTGAGCAACAGAAAAAC

>NC_017316|3|3|2561542-2561615|CRISPRCasFinder
ATAGTTGGCGAGCAACAGAAAAAC	TCGATATAGAATTGGACGTAGAGCCA
ATAGTTGGTGAGCAACAGAAAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_017316.1\|WP_002354866.1\|2570692_2571064_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226923
NC_017316.1\|WP_002406717.1\|2557809_2560554_+\|glycoside-hydrolase-family-65-protein	unknown	unknown	gnl\|CDD\|224471
NC_017316.1\|WP_080004763.1\|2561831_2562275_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376232
NC_017316.1\|WP_002354867.1\|2568115_2570692_-\|DNA-mismatch-repair-protein-MutS	unknown	unknown	gnl\|CDD\|235444
NC_017316.1\|WP_002354880.1\|2554925_2555630_-\|WxL-domain-containing-protein	unknown	unknown	gnl\|CDD\|372694
NC_017316.1\|WP_002354884.1\|2552958_2554227_-\|insulinase-family-protein	unknown	unknown	gnl\|CDD\|223685
NC_017316.1\|WP_002354873.1\|2562515_2562668_-\|putative-holin-like-toxin	unknown	unknown	gnl\|CDD\|319017
NC_017316.1\|WP_002413926.1\|2565951_2568084_-\|DNA-mismatch-repair-endonuclease-MutL	unknown	unknown	gnl\|CDD\|223400
NC_017316.1\|WP_002354879.1\|2555725_2556439_-\|WxL-domain-containing-protein	unknown	unknown	gnl\|CDD\|372694
NC_017316.1\|WP_002354875.1\|2560568_2561219_+\|beta-phosphoglucomutase	unknown	unknown	gnl\|CDD\|213672
NC_017316.1\|WP_002354871.1\|2564802_2565240_-\|peptide-methionine-(R)-S-oxide-reductase-MsrB	unknown	unknown	gnl\|CDD\|234692
NC_017316.1\|WP_002354877.1\|2556834_2557548_-\|trehalose-operon-repressor	unknown	unknown	gnl\|CDD\|274116
NC_017316.1\|WP_002359020.1\|2550627_2551494_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|224343
NC_017316.1\|WP_002354885.1\|2551661_2552966_-\|insulinase-family-protein	unknown	unknown	gnl\|CDD\|223685
NC_017316.1\|WP_002354883.1\|2554435_2554885_+\|large-conductance-mechanosensitive-channel-protein-MscL	unknown	unknown	gnl\|CDD\|376605
NC_017316.1\|WP_002354864.1\|2571152_2571950_-\|TIGR00282-family-metallophosphoesterase	unknown	unknown	gnl\|CDD\|379099
NC_017316.1\|WP_002354869.1\|2565372_2565927_-\|septum-formation-protein-Maf	unknown	unknown	gnl\|CDD\|238310
NC_017316.1\|WP_002354863.1\|2572109_2573666_-\|ribonuclease-Y	unknown	unknown	gnl\|CDD\|237177
NC_017316.1\|WP_002365385.1\|2550069_2550324_-\|hypothetical-protein	unknown	unknown	unknown
NC_017316.1\|WP_002381060.1\|2563656_2564628_-\|ribose-phosphate-diphosphokinase	unknown	unknown	gnl\|CDD\|234929

Protein	Function_ID	Function_description	E-value
NC_017316.1\|WP_002354866.1\|2570692_2571064_-\|hypothetical-protein	gnl\|CDD\|226923	COG4550, COG4550, Predicted membrane protein [Function unknown].	8.72333e-15
NC_017316.1\|WP_002406717.1\|2557809_2560554_+\|glycoside-hydrolase-family-65-protein	gnl\|CDD\|224471	COG1554, ATH1, Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism].	1.36625e-172
NC_017316.1\|WP_080004763.1\|2561831_2562275_+\|hypothetical-protein	gnl\|CDD\|376232	pfam18813, PBECR4, phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease4. A predicted endoRNase of the Barnase-EndoU-ColicinE5/D-RelE like nuclease fold found in polyvalent proteins of phages and conjugative elements. The predicted active site contains a conserved histidine residue.	2.98186e-16
NC_017316.1\|WP_002354867.1\|2568115_2570692_-\|DNA-mismatch-repair-protein-MutS	gnl\|CDD\|235444	PRK05399, PRK05399, DNA mismatch repair protein MutS; Provisional.	0
NC_017316.1\|WP_002354880.1\|2554925_2555630_-\|WxL-domain-containing-protein	gnl\|CDD\|372694	pfam13731, WxL, WxL domain surface cell wall-binding. The WxL motif appears in two or three copies in these bacterial proteins and confers a cell surface localization function. It seems likely that this region is the cell wall-binding domain of gram-positive bacteria, and may interact with the peptidoglycan.	8.69071e-14
NC_017316.1\|WP_002354884.1\|2552958_2554227_-\|insulinase-family-protein	gnl\|CDD\|223685	COG0612, PqqL, Predicted Zn-dependent peptidases [General function prediction only].	1.15225e-51
NC_017316.1\|WP_002354873.1\|2562515_2562668_-\|putative-holin-like-toxin	gnl\|CDD\|319017	pfam16935, Hol_Tox, Putative Holin-like Toxin (Hol-Tox). Hol_Tox is a family of small proteins (34-48aas) with a single TM region. Members can exhibit antibacterial activity against Gram-positive bacteria but not against Gram-negative bacteria.	6.38667e-13
NC_017316.1\|WP_002413926.1\|2565951_2568084_-\|DNA-mismatch-repair-endonuclease-MutL	gnl\|CDD\|223400	COG0323, MutL, DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair].	0
NC_017316.1\|WP_002354879.1\|2555725_2556439_-\|WxL-domain-containing-protein	gnl\|CDD\|372694	pfam13731, WxL, WxL domain surface cell wall-binding. The WxL motif appears in two or three copies in these bacterial proteins and confers a cell surface localization function. It seems likely that this region is the cell wall-binding domain of gram-positive bacteria, and may interact with the peptidoglycan.	5.58773e-17
NC_017316.1\|WP_002354875.1\|2560568_2561219_+\|beta-phosphoglucomutase	gnl\|CDD\|213672	TIGR01990, bPGM, beta-phosphoglucomutase. This model represents the beta-phosphoglucomutase enzyme which catalyzes the interconverison of beta-D-glucose-1-phosphate and beta-D-glucose-6-phosphate. The 6-phosphate is capable of non-enzymatic anomerization (alpha <-> beta) while the 1-phosphate is not. A separate enzyme is responsible for the isomerization of the alpha anomers. Beta-D-glucose-1-phosphate results from the phosphorylysis of maltose (2.4.1.8), trehalose (2.4.1.64) or trehalose-6-phosphate (2.4.1.216). Alternatively, these reactions can be run in the synthetic direction to create the disaccharides. All sequenced genomes which contain a member of this family also appear to contain at least one putative maltose or trehalose phosphorylase. Three species, Lactococcus, Enterococcus and Neisseria appear to contain a pair of paralogous beta-PGM's. Beta-phosphoglucomutase is a member of the haloacid dehalogenase superfamily of hydrolase enzymes. These enzymes are characterized by a series of three catalytic motifs positioned within an alpha-beta (Rossman) fold. beta-PGM contains an inserted alpha helical domain in between the first and second conserved motifs and thus is a member of subfamily IA of the superfamily. The third catalytic motif comes in three variants, the third of which, containing a conserved DD or ED, is the only one found here as well as in several other related enzymes (TIGR01509). The enzyme from L. lactis has been extensively characterized including a remarkable crystal structure which traps the pentacoordinate transition state. [Energy metabolism, Biosynthesis and degradation of polysaccharides].	7.1375e-106
NC_017316.1\|WP_002354871.1\|2564802_2565240_-\|peptide-methionine-(R)-S-oxide-reductase-MsrB	gnl\|CDD\|234692	PRK00222, PRK00222, peptide-methionine (R)-S-oxide reductase MsrB.	2.48715e-93
NC_017316.1\|WP_002354877.1\|2556834_2557548_-\|trehalose-operon-repressor	gnl\|CDD\|274116	TIGR02404, Trehalose_operon_transcriptional_repressor, trehalose operon repressor, B. subtilis-type. This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions].	6.92052e-137
NC_017316.1\|WP_002359020.1\|2550627_2551494_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|224343	COG1426, COG1426, Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown].	2.66641e-35
NC_017316.1\|WP_002354885.1\|2551661_2552966_-\|insulinase-family-protein	gnl\|CDD\|223685	COG0612, PqqL, Predicted Zn-dependent peptidases [General function prediction only].	3.18356e-85
NC_017316.1\|WP_002354883.1\|2554435_2554885_+\|large-conductance-mechanosensitive-channel-protein-MscL	gnl\|CDD\|376605	pfam01741, MscL, Large-conductance mechanosensitive channel, MscL.	2.8499e-49
NC_017316.1\|WP_002354864.1\|2571152_2571950_-\|TIGR00282-family-metallophosphoesterase	gnl\|CDD\|379099	pfam13277, YmdB, YmdB-like protein. This family of putative phosphoesterases contains the B. subtilis protein YmdB.	2.68643e-155
NC_017316.1\|WP_002354869.1\|2565372_2565927_-\|septum-formation-protein-Maf	gnl\|CDD\|238310	cd00555, Maf, Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or nucleic acid-binding protein with structural similarity to the hypoxanthine/xanthine NTP pyrophosphatase Ham1 from Methanococcus jannaschii, RNase H from Escherichia coli, and some other nucleotide or RNA-binding proteins.	1.6551e-85
NC_017316.1\|WP_002354863.1\|2572109_2573666_-\|ribonuclease-Y	gnl\|CDD\|237177	PRK12704, PRK12704, phosphodiesterase; Provisional.	0
NC_017316.1\|WP_002381060.1\|2563656_2564628_-\|ribose-phosphate-diphosphokinase	gnl\|CDD\|234929	PRK01259, PRK01259, ribose-phosphate diphosphokinase.	0

>NC_017316.1|WP_002354875.1|2560568_2561219_+|beta-phosphoglucomutase
MTIGFIFDLDGVITDTAKFHYQAWKALADSLGISIDETFNETLKGISRMDSLDRILAHGHRENAFTPAEKEALAQQKNDHYVQLLEHLTTEDVLPGVVPLLQQAQARHIPCAVASASKNAPLILEKLGVRAYFATIVDPDSLSKGKPDPEIFLAAADSIGVLPQNAIGFEDAQSGIDGLKAAGIYAVGLSASQPLIGADMQVSEMTELSVDALLNR
>NC_017316.1|WP_002406717.1|2557809_2560554_+|glycoside-hydrolase-family-65-protein
MSIQVHKEAPNMTILELTFATNQLTTTFFNHKLEPLHQKTFPFEALTIEETVPELCQLIVAEAAPILGGIVADFPEDFFSPEETLALVPQAVIQAFAEQLNTPLLTAAEQAAAPNLLAAFEEKRQYLAWHLDYYGYVPGKNEYAVESLLTVGNGFLGLRGTTPEMTISDDHYPATYIAGLYNTAASEVAGQVVENEDFVNAPDNQHIALKIGDATDWLTISPDTLQQLHRQLNLKTGLFVAEMILKDADNQQIKLTTKKIANMAQPNDYHLQYTFEPLNFSAPITLKTVTDGSVYNYNVARYRNLTAKHFQVTALSAQENKTVIEVCTNQSNLSVRETALITGDFFEKEAIMIQEEAEKIAQVVTVMAHQGTRYTLEKQVFVQASHAEQSWQVPFTPRDSFAAAAQESARAWQTLWQQANITVTGDLMSQKLLRIHSYHLLASASPFSNQAQALDVSITARGLHGEAYRGHIFWDEIFILPFYIQHYPDTAKQLLLYRYHRLEKAKENAAASQYRGAMYPWQSGRDGRETTQKLHLNPLNGHWGEDHSILQRHVSLAIAYNAWLYWHSTQDHEFMKQYGGEMLLEIAQFWNSAATLDDATGRFFIDKVMGPDEFHEGYPDQAESGLKNNAYTNLMVVWLFEELTNILALFSEEEQAQLFAKTQTSSADLARMQQIQNSLEIEVNSDGIIAQYEGYFGLKEIDWAAMKEKYGNIYRMDRILKAEGESPDDYKVAKQADTLMLFYNLDKTRVDQILEDLGYQLPADYLEKNLLYYLKRTSHGSTLSRIVHAQLAEMAQFHELSWQLYQEALYSDYRDIQGGTTAEGIHTGVMAATIHVTLATYAGVDTRQNELSICPNLPEHWQALAFQFIHQGVTYQFSLTQTSVTITADKDTQLLVQGALIPLTAERPKEVHYQ
>NC_017316.1|WP_002354877.1|2556834_2557548_-|trehalose-operon-repressor
MNKFHDIFLELEQQIVQGDYQPGDLLPSENQLVETYNVSRETIRKALNLLINAGYIQKKQGKGSIVLNFKKFNFPISGVTSYKELQQTQHIESHTHVVSLEEIPVERNLAQLTGWTEGAPVWRLVRQREIEGEVDILDIDYLIKEIVPELPKHRAEDSIFDYLENDLGLAISYAQKEITVEPLTEMDKQLIGEVEGNHVVVVRSIMNLEDTRCFGYTESRHRLNKFKFVEFARRRKL
>NC_017316.1|WP_002354879.1|2555725_2556439_-|WxL-domain-containing-protein
MKKKIMASLLVGSAVVGASLAPLSAQAVTTGNTPVQAEFEGGSLPDIGGDPNTVRPDPGATNSNFDLLFIPREYDFGKLSISDDLTKSIPNKNDVGTNGHVEAVGVGDLRGTKEGWHVTAQSNGMKFDEESLEGNITTSSNSLYPLEYDVVNNYFRILDFTFLDPNTSPNLVNSDNWTLDLGGDAVLVSNASVGKGQGLWQFTMFRTSLNITTPAYEIKAGAYTGNITWNLVAGPSI
>NC_017316.1|WP_002354880.1|2554925_2555630_-|WxL-domain-containing-protein
MKKKIMASLLVGSAVVGASLAPLSAQAVTTGNTPVQVEFGGGVLPDHEDNTGGSVDPDPTKPNTDFDLLAIPRSFDFPLVKIGEDLTSIKSISPQFRPPSVMVGDVRGTKEGWHVTGEIAEMKNGTDKLDGQFNFGMTPYYAVFNASTGLYGGMASQNGMNITDDPTAPSFIGTNMTIGGGATTLMNATVGQGQGTWSGRIDNMTLNVTTPYQQIKAGAYTGNITWNLVAGPSI
>NC_017316.1|WP_002354883.1|2554435_2554885_+|large-conductance-mechanosensitive-channel-protein-MscL
MIKEFKEFIMRGSVLDLAVGVVIGSAFTAIVTQVVEGLITPLISLIFVLTTGKKSADDALGALVYKVEGVEFNIGSVISALITFLITAFVLFLIVKAANKMKNRGKKEEAAEEEVVPTSEDYLKEIRDLLAAQTPPAETVKTDSTFTEK
>NC_017316.1|WP_002354884.1|2552958_2554227_-|insulinase-family-protein
MSVQLVKGVNLHVIPTEKYKTVRLLVRFNTRLNHETITKRTLLSSLMETNSLNYPNQVKLSERLAELYGASFGIGVSKKGNQHWFNISMNIVNDHYLQDSQVLAEAVDFLKEIIFAPNIQAGQFEAETFQREKENLKAYLESIVEDKQTYASLALQSVYFNQSEDQKIPSFGTVAALAEETAASLAAYYQKMLAEDQVDIFVLGDVNEAELVPLFKQLPFTPREEGKAAIFYNQPIRNVIEERTEREVLAQSKLNLAYNTDIYYGDSYYFALQVFNGIFGGFPHSKLFMNVREKEHLAYYASSSIDTFRGFMTVQTGIDGKNRNQVLRLISTELENIRLGKISELEIEQTKAMLKNQYILALDNAGAWLEKEYLNELMPQTMLTAEEWIARINAVTISEIQEVAKRLELQAIFFLEGETEND
>NC_017316.1|WP_002354885.1|2551661_2552966_-|insulinase-family-protein
MIKKDYAQIKETLYTETLANGLKVYLLPKNDFQKTYGLFTTDYGSIDNTFVPIGQEEMIEVPDGIAHFLEHKMFEKEDGDVFQKFGQQGASANAFTSFTKTSYLFSTTDQVTQNLETLLDFVQSPYFTKETVEKEKGIIGQEIQMYLDDPNWRLFFGILGNLYPKHPLHIDIAGTVASIAEITAEDLYTCYNTFYHPSNMTLFVVGKMDPEALMAFIRENQAAKEFPAAQPIRRHFPEETAADIVKESAIEMAVTRAKVLVGLKGLDEVPTTGRDLMKYQVTVNLLLQLLFGNTSQNYLALYDEGLLDDSFSYDFNLDRSFHFADIGGDSEQPEVLAERIEAILLSATTSPELTEENLSLLKKKMIGKYFQSLNSLEYIANQFSQSLFGETTLFDKIEVIESIQLADVRQVAETLIREEGLSRFYMYPKGETEQ
>NC_017316.1|WP_002359020.1|2550627_2551494_-|helix-turn-helix-domain-containing-protein
MASVNIGETLKEARLQKNISIDELQQMTKIQKRYLEIIEQNDFESLPGTFYVRAFIRQYASAVGLDGNQLVDIYDGKEPAIVEEPKPVYEELEGSRKQLHDEEKQSSWLLRNLPAIAFSLIGLAIAVVVLYIMWQDQKAEPIIQTPATSASVEKPKESSQAPESSTQSSTPPSSSSEPEKKTAVAVVSDANNQVTATVKDANSPINITFKGTEGSCWIGVMVDGNYTYQHTLQAGETQTTALPANAANATLILGASNNVAIQVDGADLTLEKTPVLIRKDVTLGITYR
>NC_017316.1|WP_002365385.1|2550069_2550324_-|hypothetical-protein
MVKIASNQGAAQKAIAGIKNVSVNKNQTCHLGESNISSMKKGVKVSNQLLNQLAKVVNGVNAQANKFPKLAATIAARDSQTTFK
>NC_017316.1|WP_080004763.1|2561831_2562275_+|hypothetical-protein
MHLCGVDYYQIDKQGSCKFRFKATQFYRALKNNKVSLRGIKPKDDGTTGQKLQVIPLLEMLISPGVRVCDGGKFYNLQYEKAIRSGKMIVALTCKENNKKYVPQSLLSLINQPRKSQSKSLTESHEVIKISKSELNSTSVIEVYDKF
>NC_017316.1|WP_002354873.1|2562515_2562668_-|putative-holin-like-toxin
MVRMSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK
>NC_017316.1|WP_002381060.1|2563656_2564628_-|ribose-phosphate-diphosphokinase
MSKHYFDPRLKIFSLNSNRPLAEKIADAVGVELGKCSVTQFSDGEIQVNIEESIRGAHVYVIQSTSSPVNDNLMELLIMIDALKRASAKTINVVMPYYGYARQDRKARAREPITAKLVANMIEKAGATRMLTLDLHAVQIQGFFDIPVDHLMGAPLIADYFIEHGIQGDDVVVVSPDHGGVTRARKLAEFLKAPIAIIDKRRPKANVAEVMNIIGHVEGKTCVLIDDMIDTAGTISLAANALKEAGAKDVYASCTHPVLSGPALQRIEDSAIERLVVTDSIYLSDDRKIAKIDEVSVGELIGDAIKRIHENKPVSPLFETKNK
>NC_017316.1|WP_002354871.1|2564802_2565240_-|peptide-methionine-(R)-S-oxide-reductase-MsrB
MTKPTEEELKQTLTDLQYAVTQENATERPFSGEYDDFYQDGIYVDIVSGEPLFSSLDKYDAGCGWPSFTKPIEKRGVKEKADFSHGMHRVEVRSQEADSHLGHVFTDGPLQEGGLRYCINAAALRFVPVADLEKEGYGEYLSLFK
>NC_017316.1|WP_002354869.1|2565372_2565927_-|septum-formation-protein-Maf
MQIILASQSPRRQELLKRVVPTFTIAPADIDETVGKDGLPAEYVAQMAAQKAAAIAEQSPEALVIGCDTIVALAGEILGKPTSREDGYRMLRLLSGKTHDVYTSVTLKQGEKERSATVHSTVTFYPLTDTEIHAYLDTAEYADKAGAYGIQGQGALLIEAIAGDYYAIMGLPIAKVARLLKEFN
>NC_017316.1|WP_002413926.1|2565951_2568084_-|DNA-mismatch-repair-endonuclease-MutL
MGKIQELSEQLANQIAAGEVVERPASVVKELVENALDAGSTQIDIFIEEAGLKTIQIIDNGEGIAKEDVLNAFKRHATSKIHTRDDLFRIRSLGFRGEALPSIASVSEMIVETATAEEEEGSYVILKGGKVEENRPAALRKGTKMTVSNLFYNTPARLKYVKTIQTELANIGDIVNRLALSHPKVAFRLVHDGHKMMSTTGNGDLKQTIAGIYGISTAKKMLKIEGKDLDFTLTGYVSLPEVTRASRNYLSTIINGRYIKNFALNKAIVAGYGSKLMVGRFPIAVLEIEMDPLLVDVNVHPTKQEVRLSKEKDLMALIEQAIQEVLSQEQLIPNAADNLRFKKKLPPEPKAEQMEIPLSTEQPAVKQRPGSLSYNPATGRFYAEHATDETPASSAPEAVNQTERAVDPMDDPFAPPVPESTSVAEETSAYETSSAAADSANHWETASNEQQVIAEETKITEVPDSEPSLRSSEAADEVFQEEMKLHPEFDANSAASQRELKQALNKLEEERPTERFPELEYFGQMHGTYLFAQSKDGLFIIDQHAAQERIKYEYFREKIGEVSDDLQELLVPIIIDYPNSDALKIKEQKETLAEVGIHLEDFGQNSFIVRAHPTWYPAGEEESIVREMIDMLLTTGSVSVKKFREATAIMMSCKRSIKANHYLNEQQARVLLKDLALCENPFNCPHGRPVLIHFTNSDMERMFKRIQDPH
>NC_017316.1|WP_002354867.1|2568115_2570692_-|DNA-mismatch-repair-protein-MutS
MPQKTKNTPMMEQYLSIKAQYKDAFLFYRLGDFYELFYEDAINAAQILELTLTSRNRNADDPIPMCGVPYHAAQGYIDTLIEQGYKVAICEQVEDPKTTKGMVKREVVQLVTPGTVMNSKGLEAKDNNYLTAVLTDGNQFGFAYVDLSTGELKTAVLADEEGVLNEASALQTKEMVLGSGIPESLKENLSLRLNIIFSTQETVEENAEFSFLTNELINPLEIEITGKLLSYLSVTQKRSLSHIQKAVEYQPDHFLKMDHYSKFNLELSQSIRTGQKKGTLLWLLDETKTAMGGRLLKQWLDRPLIQERQIKARQEMVQSLLNAYFERLDLQAALTNVYDLERLAGRVAFGSVNGRDLIQLRTSLEQVPTIRQLIVGINQGEWDDLLVDLNPVEDLVALIATAINEEAPLQITEGNVIKDGYNDQLDEYRDAMRNGKQWLAELEAKERQETGIKNLKIGYNRVFGYFIEITKSNLANLEEGKYERKQTLANAERFITPELKELERLILEAEEKSVELEYQLFLAVREQVKTNIDRLQTLAKTISAVDVLQSFATISERYQYVRPTLRSNTKNLAIVEGRHPVVEKVLGHQEYIPNSIRMNPETDILLITGPNMSGKSTYMRQLALTVVMAQIGCFVPAESAEMPIFDQIFTRIGASDDLIAGQSTFMVEMMEANQALRHATPNSLILFDELGRGTATYDGMALAQAIIEYIHREVQAKTLFSTHYHELTVLDETLKGLKNIHVGAVEKDGEVVFLHKMMEGPADKSYGIHVAKIAGLPSPLLERAATILSALEAEETTIPSSVHHEEVSEVHEETEQLSLFKEVSTEELSVIDTLKKMNLLEMTPLDALNMLHQLQKRI
>NC_017316.1|WP_002354866.1|2570692_2571064_-|hypothetical-protein
MEPLNLDAQSNKELEKLLHLIGQDEVIQRYQAIEEKVKKNKKLTELVEEIKAAQKDAVQFAHYGKPTAEKEAIQRADAKTKEFDEHPLVVAYREQLIEANDLVQHVTALIQYRVNEELEKEGN
>NC_017316.1|WP_002354864.1|2571152_2571950_-|TIGR00282-family-metallophosphoesterase
MRILFIGDVVGSLGREALATYVPKLKKKYRPQVTIANGENAASGRGITGKIYKKFLQDGVDVVTMGNHTWDNKDIFEFIDDAKKMVRPANFPEDVPGQGMVFVKVNQLELAVINLQARTFMVPLEDPFKKAAELVAIARKRTPLIFVDFHGETTSEKQAMSWFLDGQVSAVVGTHTHVQTNDARILPKGTAFLSDVGMTGPYDGILGMKREPIIEKFMTALPKRFEVVETGRTILSACILEIDDQTGQAKMIEPIQISEDRPFQE
>NC_017316.1|WP_002354863.1|2572109_2573666_-|ribonuclease-Y
MVLNILLAIVGLIVGLGLGFVIAKSRHDKAINGAKISASSILENARKESETLKKEALLEAKEENQKYRSEIESELKESRLELKSQENRLIQREQTLDRKDDSLEKREGSLEEKEEKLGARQQLIDEREKEVENLINQQHQELERIASLSKEEAKSIIMKSTEEELNHELTLMVKESEQRAKEESDRKAKNLLSLAIQRCAADSVSETTVSVVTLPNDEMKGRIIGREGRNIRTLETLTGIDLIIDDTPEAVVLSGFDPIRREIARMTLEKLIQDGRIHPARIEEMVEKSRKEMDERIREYGEQAAFEVGAHTLHPDLIKILGRLRFRTSYGQNVLNHSIEVAKLAGVLAAELGEDVQLAKRAGLLHDIGKALDHEIEGSHVEIGAELAAKYKENSVVINAIASHHGDVEATSVISVLVAAADALSAARPGARSESLENYIRRLENLENISNSFEGVDSSFAVQAGREVRVMVKPEEISDLESVRLVRDIRKKIEDDLDYPGHIKVTVIRETRAVDYAK

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_017316_2	2.3\|1738356\|29\|NC_017316\|CRISPRCasFinder	1738356-1738384	29	NZ_CP041739	Enterococcus faecalis EnGen0107 strain B594 plasmid p1, complete sequence	39957-39985	0	1.0
NC_017316_2	2.3\|1738356\|29\|NC_017316\|CRISPRCasFinder	1738356-1738384	29	NZ_CP030043	Enterococcus faecalis strain C25 plasmid pC25-1, complete sequence	37120-37148	0	1.0
NC_017316_2	2.3\|1738356\|29\|NC_017316\|CRISPRCasFinder	1738356-1738384	29	NZ_CP030046	Enterococcus faecalis strain C54 plasmid pC54, complete sequence	53178-53206	0	1.0
NC_017316_2	2.6\|1738554\|29\|NC_017316\|CRISPRCasFinder	1738554-1738582	29	MK721192	Enterococcus phage vB_EfaM_Ef2.3, complete genome	137122-137150	0	1.0
NC_017316_2	2.6\|1738554\|29\|NC_017316\|CRISPRCasFinder	1738554-1738582	29	AP018714	Enterococcus phage phiEF17H DNA, complete sequence	102453-102481	0	1.0
NC_017316_2	2.10\|1738356\|30\|NC_017316\|CRT,PILER-CR	1738356-1738385	30	NZ_CP041739	Enterococcus faecalis EnGen0107 strain B594 plasmid p1, complete sequence	39957-39986	0	1.0
NC_017316_2	2.10\|1738356\|30\|NC_017316\|CRT,PILER-CR	1738356-1738385	30	NZ_CP030043	Enterococcus faecalis strain C25 plasmid pC25-1, complete sequence	37120-37149	0	1.0
NC_017316_2	2.10\|1738356\|30\|NC_017316\|CRT,PILER-CR	1738356-1738385	30	NZ_CP030046	Enterococcus faecalis strain C54 plasmid pC54, complete sequence	53177-53206	0	1.0
NC_017316_2	2.13\|1738554\|30\|NC_017316\|CRT,PILER-CR	1738554-1738583	30	MK721192	Enterococcus phage vB_EfaM_Ef2.3, complete genome	137122-137151	0	1.0
NC_017316_2	2.13\|1738554\|30\|NC_017316\|CRT,PILER-CR	1738554-1738583	30	AP018714	Enterococcus phage phiEF17H DNA, complete sequence	102453-102482	0	1.0
NC_017316_2	2.3\|1738356\|29\|NC_017316\|CRISPRCasFinder	1738356-1738384	29	NZ_CP022484	Enterococcus faecalis ARO1/DG plasmid pARO1.1, complete sequence	35711-35739	1	0.966
NC_017316_2	2.3\|1738356\|29\|NC_017316\|CRISPRCasFinder	1738356-1738384	29	NZ_CP036248	Enterococcus faecalis R712 plasmid pR712_02, complete sequence	48630-48658	1	0.966
NC_017316_2	2.3\|1738356\|29\|NC_017316\|CRISPRCasFinder	1738356-1738384	29	NZ_CP042217	Enterococcus faecalis strain L8 plasmid pL8, complete sequence	41684-41712	1	0.966
NC_017316_2	2.3\|1738356\|29\|NC_017316\|CRISPRCasFinder	1738356-1738384	29	NZ_MK140641	Enterococcus faecalis strain E035 plasmid pE035, complete sequence	53006-53034	1	0.966
NC_017316_2	2.6\|1738554\|29\|NC_017316\|CRISPRCasFinder	1738554-1738582	29	CAJDJZ010000002	Enterococcus phage vB_EfaH_149 genome assembly, contig: phage149-genome, whole genome shotgun sequence	104698-104726	1	0.966
NC_017316_2	2.6\|1738554\|29\|NC_017316\|CRISPRCasFinder	1738554-1738582	29	CAJDJY010000002	Enterococcus phage 156 genome assembly, contig: phage156-genome, whole genome shotgun sequence	100916-100944	1	0.966
NC_017316_2	2.6\|1738554\|29\|NC_017316\|CRISPRCasFinder	1738554-1738582	29	LR031359	Enterococcus phage 156, complete genome	100916-100944	1	0.966
NC_017316_2	2.10\|1738356\|30\|NC_017316\|CRT,PILER-CR	1738356-1738385	30	NZ_CP022484	Enterococcus faecalis ARO1/DG plasmid pARO1.1, complete sequence	35711-35740	1	0.967
NC_017316_2	2.10\|1738356\|30\|NC_017316\|CRT,PILER-CR	1738356-1738385	30	NZ_CP036248	Enterococcus faecalis R712 plasmid pR712_02, complete sequence	48629-48658	1	0.967
NC_017316_2	2.10\|1738356\|30\|NC_017316\|CRT,PILER-CR	1738356-1738385	30	NZ_CP042217	Enterococcus faecalis strain L8 plasmid pL8, complete sequence	41683-41712	1	0.967
NC_017316_2	2.10\|1738356\|30\|NC_017316\|CRT,PILER-CR	1738356-1738385	30	NZ_MK140641	Enterococcus faecalis strain E035 plasmid pE035, complete sequence	53005-53034	1	0.967
NC_017316_2	2.13\|1738554\|30\|NC_017316\|CRT,PILER-CR	1738554-1738583	30	CAJDJZ010000002	Enterococcus phage vB_EfaH_149 genome assembly, contig: phage149-genome, whole genome shotgun sequence	104698-104727	1	0.967
NC_017316_2	2.13\|1738554\|30\|NC_017316\|CRT,PILER-CR	1738554-1738583	30	CAJDJY010000002	Enterococcus phage 156 genome assembly, contig: phage156-genome, whole genome shotgun sequence	100916-100945	1	0.967
NC_017316_2	2.13\|1738554\|30\|NC_017316\|CRT,PILER-CR	1738554-1738583	30	LR031359	Enterococcus phage 156, complete genome	100916-100945	1	0.967
NC_017316_2	2.3\|1738356\|29\|NC_017316\|CRISPRCasFinder	1738356-1738384	29	NZ_CP015884	Enterococcus faecalis strain sorialis plasmid Efsorialis-p1, complete sequence	44693-44721	3	0.897
NC_017316_2	2.10\|1738356\|30\|NC_017316\|CRT,PILER-CR	1738356-1738385	30	NZ_CP015884	Enterococcus faecalis strain sorialis plasmid Efsorialis-p1, complete sequence	44693-44722	3	0.9
NC_017316_2	2.1\|1738224\|29\|NC_017316\|CRISPRCasFinder	1738224-1738252	29	NZ_LR214986	Mycoplasma cynos strain NCTC10142 plasmid 13	726854-726882	5	0.828
NC_017316_2	2.8\|1738224\|30\|NC_017316\|CRT	1738224-1738253	30	NZ_LR214986	Mycoplasma cynos strain NCTC10142 plasmid 13	726854-726883	5	0.833
NC_017316_1	1.1\|422523\|29\|NC_017316\|CRISPRCasFinder,CRT	422523-422551	29	NZ_CP012104	Bacillus thuringiensis strain HS18-1 plasmid pHS18-5, complete sequence	18931-18959	6	0.793
NC_017316_2	2.3\|1738356\|29\|NC_017316\|CRISPRCasFinder	1738356-1738384	29	NZ_CP023544	Campylobacter jejuni strain CFSAN032806 plasmid pCFSAN032806, complete sequence	42911-42939	6	0.793
NC_017316_2	2.3\|1738356\|29\|NC_017316\|CRISPRCasFinder	1738356-1738384	29	NZ_CP017872	Campylobacter coli strain BP3183 plasmid pCCDM183, complete sequence	31018-31046	6	0.793
NC_017316_2	2.3\|1738356\|29\|NC_017316\|CRISPRCasFinder	1738356-1738384	29	NC_022355	Campylobacter coli CVM N29710 plasmid pN29710-1, complete sequence	42878-42906	6	0.793
NC_017316_2	2.3\|1738356\|29\|NC_017316\|CRISPRCasFinder	1738356-1738384	29	NZ_CP045793	Campylobacter coli strain CFSAN032805 plasmid p1CFSAN032805, complete sequence	32830-32858	6	0.793
NC_017316_2	2.3\|1738356\|29\|NC_017316\|CRISPRCasFinder	1738356-1738384	29	NZ_CP023546	Campylobacter coli strain CFSAN032805 plasmid pCFSAN032805_1, complete sequence	33401-33429	6	0.793
NC_017316_2	2.5\|1738488\|29\|NC_017316\|CRISPRCasFinder	1738488-1738516	29	NZ_CP049227	Lactobacillus iners strain C0011D1 plasmid pC0011D1, complete sequence	27670-27698	6	0.793
NC_017316_2	2.6\|1738554\|29\|NC_017316\|CRISPRCasFinder	1738554-1738582	29	NC_009929	Acaryochloris marina MBIC11017 plasmid pREB4, complete sequence	66076-66104	6	0.793
NC_017316_2	2.8\|1738224\|30\|NC_017316\|CRT	1738224-1738253	30	NC_019526	Enterobacteria phage vB_KleM-RaK2, complete genome	41998-42027	6	0.8
NC_017316_2	2.8\|1738224\|30\|NC_017316\|CRT	1738224-1738253	30	MT708547	Klebsiella phage Muenster, complete genome	164106-164135	6	0.8
NC_017316_2	2.8\|1738224\|30\|NC_017316\|CRT	1738224-1738253	30	AB897757	Klebsiella phage K64-1 DNA, complete genome	42006-42035	6	0.8
NC_017316_2	2.12\|1738488\|30\|NC_017316\|CRT,PILER-CR	1738488-1738517	30	NZ_CP049227	Lactobacillus iners strain C0011D1 plasmid pC0011D1, complete sequence	27669-27698	6	0.8
NC_017316_2	2.13\|1738554\|30\|NC_017316\|CRT,PILER-CR	1738554-1738583	30	NC_009929	Acaryochloris marina MBIC11017 plasmid pREB4, complete sequence	66076-66105	6	0.8
NC_017316_1	1.4\|422721\|29\|NC_017316\|CRISPRCasFinder,CRT	422721-422749	29	HQ906663	Wolbachia endosymbiont wVitA of Nasonia vitripennis phage WOVitA2, complete sequence	19631-19659	7	0.759
NC_017316_1	1.7\|422919\|29\|NC_017316\|CRISPRCasFinder,CRT	422919-422947	29	NC_011752	Escherichia coli 55989 plasmid 55989p, complete sequence	49973-50001	7	0.759
NC_017316_1	1.7\|422919\|29\|NC_017316\|CRISPRCasFinder,CRT	422919-422947	29	CP042952	Escherichia coli strain D8-1 plasmid pD8-1_1, complete sequence	67474-67502	7	0.759
NC_017316_1	1.7\|422919\|29\|NC_017316\|CRISPRCasFinder,CRT	422919-422947	29	NZ_CP026724	Escherichia coli strain 266917_2 plasmid p266917_2_01, complete sequence	101148-101176	7	0.759
NC_017316_1	1.7\|422919\|29\|NC_017316\|CRISPRCasFinder,CRT	422919-422947	29	CP051693	Escherichia coli strain SCU-318 plasmid pSCU-318-1, complete sequence	31503-31531	7	0.759
NC_017316_1	1.7\|422919\|29\|NC_017316\|CRISPRCasFinder,CRT	422919-422947	29	NC_019000	Escherichia coli plasmid pHUSEC41-2, complete sequence	51056-51084	7	0.759
NC_017316_1	1.7\|422919\|29\|NC_017316\|CRISPRCasFinder,CRT	422919-422947	29	NZ_CP009053	Escherichia coli NCCP15648 plasmid p15648-3, complete sequence	55603-55631	7	0.759
NC_017316_1	1.7\|422919\|29\|NC_017316\|CRISPRCasFinder,CRT	422919-422947	29	NC_018666	Escherichia coli O104:H4 str. 2011C-3493 plasmid pAA-EA11, complete sequence	10746-10774	7	0.759
NC_017316_1	1.7\|422919\|29\|NC_017316\|CRISPRCasFinder,CRT	422919-422947	29	NC_018662	Escherichia coli O104:H4 str. 2009EL-2071 plasmid pAA-09EL71, complete sequence	58558-58586	7	0.759
NC_017316_1	1.7\|422919\|29\|NC_017316\|CRISPRCasFinder,CRT	422919-422947	29	NZ_CP013186	Escherichia coli strain FORC_029 plasmid FORC_029p, complete sequence	39899-39927	7	0.759
NC_017316_1	1.7\|422919\|29\|NC_017316\|CRISPRCasFinder,CRT	422919-422947	29	NZ_CP022087	Escherichia coli O104:H4 strain FDAARGOS_348 plasmid unnamed2, complete sequence	40046-40074	7	0.759
NC_017316_1	1.7\|422919\|29\|NC_017316\|CRISPRCasFinder,CRT	422919-422947	29	CP049615	Escherichia coli O157:H7 strain K1516 plasmid pK1516-3, complete sequence	17811-17839	7	0.759
NC_017316_1	1.7\|422919\|29\|NC_017316\|CRISPRCasFinder,CRT	422919-422947	29	NC_022743	Escherichia coli plasmid pHUSEC2011-2, complete sequence	53979-54007	7	0.759
NC_017316_1	1.7\|422919\|29\|NC_017316\|CRISPRCasFinder,CRT	422919-422947	29	NZ_CP031904	Escherichia coli O104:H4 strain FWSEC0009 plasmid unnamed19, complete sequence	60570-60598	7	0.759
NC_017316_1	1.7\|422919\|29\|NC_017316\|CRISPRCasFinder,CRT	422919-422947	29	NC_018654	Escherichia coli O104:H4 str. 2009EL-2050 plasmid pAA-09EL50, complete sequence	17882-17910	7	0.759
NC_017316_1	1.7\|422919\|29\|NC_017316\|CRISPRCasFinder,CRT	422919-422947	29	NZ_CP023530	Escherichia coli strain FDAARGOS_401 plasmid unnamed, complete sequence	6483-6511	7	0.759
NC_017316_1	1.7\|422919\|29\|NC_017316\|CRISPRCasFinder,CRT	422919-422947	29	NZ_CP041001	Escherichia coli strain FDAARGOS_772 plasmid unnamed1, complete sequence	63460-63488	7	0.759
NC_017316_1	1.7\|422919\|29\|NC_017316\|CRISPRCasFinder,CRT	422919-422947	29	CP025574	Escherichia coli strain E-1246 plasmid pE1246_1, complete sequence	51315-51343	7	0.759
NC_017316_1	1.7\|422919\|29\|NC_017316\|CRISPRCasFinder,CRT	422919-422947	29	NZ_CP023533	Escherichia coli strain FDAARGOS_403 plasmid unnamed2, complete sequence	24356-24384	7	0.759
NC_017316_1	1.7\|422919\|29\|NC_017316\|CRISPRCasFinder,CRT	422919-422947	29	NZ_CP027392	Escherichia coli O104:H4 strain FDAARGOS_349 plasmid unnamed2, complete sequence	4512-4540	7	0.759
NC_017316_1	1.7\|422919\|29\|NC_017316\|CRISPRCasFinder,CRT	422919-422947	29	NZ_CP023062	Escherichia coli strain FORC_069 plasmid pFORC69, complete sequence	55181-55209	7	0.759
NC_017316_1	1.7\|422919\|29\|NC_017316\|CRISPRCasFinder,CRT	422919-422947	29	NZ_CP023552	Escherichia coli strain FORC_043 plasmid pFORC43, complete sequence	47365-47393	7	0.759
NC_017316_1	1.7\|422919\|29\|NC_017316\|CRISPRCasFinder,CRT	422919-422947	29	NZ_KY706108	Escherichia coli strain pAA-ST131 plasmid ESBL20150001, complete sequence	60041-60069	7	0.759
NC_017316_1	1.7\|422919\|29\|NC_017316\|CRISPRCasFinder,CRT	422919-422947	29	NZ_CP031270	Staphylococcus warneri strain 16A plasmid unnamed1, complete sequence	20272-20300	7	0.759
NC_017316_1	1.7\|422919\|29\|NC_017316\|CRISPRCasFinder,CRT	422919-422947	29	NZ_CP031270	Staphylococcus warneri strain 16A plasmid unnamed1, complete sequence	9755-9783	7	0.759
NC_017316_1	1.8\|422720\|30\|NC_017316\|PILER-CR	422720-422749	30	HQ906663	Wolbachia endosymbiont wVitA of Nasonia vitripennis phage WOVitA2, complete sequence	19630-19659	7	0.767
NC_017316_2	2.2\|1738290\|29\|NC_017316\|CRISPRCasFinder	1738290-1738318	29	NC_009453	Arthrobacter sp. Rue61a plasmid pAL1, complete sequence	17952-17980	7	0.759
NC_017316_2	2.5\|1738488\|29\|NC_017316\|CRISPRCasFinder	1738488-1738516	29	NC_019526	Enterobacteria phage vB_KleM-RaK2, complete genome	9676-9704	7	0.759
NC_017316_2	2.5\|1738488\|29\|NC_017316\|CRISPRCasFinder	1738488-1738516	29	MT708547	Klebsiella phage Muenster, complete genome	131776-131804	7	0.759
NC_017316_2	2.5\|1738488\|29\|NC_017316\|CRISPRCasFinder	1738488-1738516	29	AB897757	Klebsiella phage K64-1 DNA, complete genome	9654-9682	7	0.759
NC_017316_2	2.10\|1738356\|30\|NC_017316\|CRT,PILER-CR	1738356-1738385	30	NZ_CP023544	Campylobacter jejuni strain CFSAN032806 plasmid pCFSAN032806, complete sequence	42911-42940	7	0.767
NC_017316_2	2.10\|1738356\|30\|NC_017316\|CRT,PILER-CR	1738356-1738385	30	NZ_CP017872	Campylobacter coli strain BP3183 plasmid pCCDM183, complete sequence	31018-31047	7	0.767
NC_017316_2	2.10\|1738356\|30\|NC_017316\|CRT,PILER-CR	1738356-1738385	30	NC_022355	Campylobacter coli CVM N29710 plasmid pN29710-1, complete sequence	42878-42907	7	0.767
NC_017316_2	2.10\|1738356\|30\|NC_017316\|CRT,PILER-CR	1738356-1738385	30	NZ_CP045793	Campylobacter coli strain CFSAN032805 plasmid p1CFSAN032805, complete sequence	32829-32858	7	0.767
NC_017316_2	2.10\|1738356\|30\|NC_017316\|CRT,PILER-CR	1738356-1738385	30	NZ_CP023546	Campylobacter coli strain CFSAN032805 plasmid pCFSAN032805_1, complete sequence	33400-33429	7	0.767
NC_017316_1	1.4\|422721\|29\|NC_017316\|CRISPRCasFinder,CRT	422721-422749	29	AB161975	Wolbachia phage WOcauB1 genomic DNA, partial sequence	4745-4773	8	0.724
NC_017316_1	1.7\|422919\|29\|NC_017316\|CRISPRCasFinder,CRT	422919-422947	29	KU886273	Freshwater phage uvFW-CGR-AMD-COM-C455, complete genome	26680-26708	8	0.724
NC_017316_1	1.8\|422720\|30\|NC_017316\|PILER-CR	422720-422749	30	AB161975	Wolbachia phage WOcauB1 genomic DNA, partial sequence	4744-4773	8	0.733
NC_017316_2	2.1\|1738224\|29\|NC_017316\|CRISPRCasFinder	1738224-1738252	29	NC_019526	Enterobacteria phage vB_KleM-RaK2, complete genome	41999-42027	8	0.724
NC_017316_2	2.1\|1738224\|29\|NC_017316\|CRISPRCasFinder	1738224-1738252	29	MT708547	Klebsiella phage Muenster, complete genome	164107-164135	8	0.724
NC_017316_2	2.1\|1738224\|29\|NC_017316\|CRISPRCasFinder	1738224-1738252	29	AB897757	Klebsiella phage K64-1 DNA, complete genome	42007-42035	8	0.724
NC_017316_2	2.5\|1738488\|29\|NC_017316\|CRISPRCasFinder	1738488-1738516	29	NZ_AP019717	Clostridium butyricum strain NBRC 13949 plasmid pCBU1, complete sequence	251577-251605	8	0.724
NC_017316_2	2.9\|1738290\|30\|NC_017316\|CRT,PILER-CR	1738290-1738319	30	NC_009453	Arthrobacter sp. Rue61a plasmid pAL1, complete sequence	17952-17981	8	0.733
NC_017316_2	2.12\|1738488\|30\|NC_017316\|CRT,PILER-CR	1738488-1738517	30	NC_019526	Enterobacteria phage vB_KleM-RaK2, complete genome	9675-9704	8	0.733
NC_017316_2	2.12\|1738488\|30\|NC_017316\|CRT,PILER-CR	1738488-1738517	30	MT708547	Klebsiella phage Muenster, complete genome	131775-131804	8	0.733
NC_017316_2	2.12\|1738488\|30\|NC_017316\|CRT,PILER-CR	1738488-1738517	30	AB897757	Klebsiella phage K64-1 DNA, complete genome	9653-9682	8	0.733
NC_017316_2	2.12\|1738488\|30\|NC_017316\|CRT,PILER-CR	1738488-1738517	30	NZ_AP019717	Clostridium butyricum strain NBRC 13949 plasmid pCBU1, complete sequence	251576-251605	9	0.7

1. spacer 2.3|1738356|29|NC_017316|CRISPRCasFinder matches to NZ_CP041739 (Enterococcus faecalis EnGen0107 strain B594 plasmid p1, complete sequence) position: , mismatch: 0, identity: 1.0

ggagaaatgtagctgctgttttgacatta	CRISPR spacer
ggagaaatgtagctgctgttttgacatta	Protospacer
*****************************

2. spacer 2.3|1738356|29|NC_017316|CRISPRCasFinder matches to NZ_CP030043 (Enterococcus faecalis strain C25 plasmid pC25-1, complete sequence) position: , mismatch: 0, identity: 1.0

ggagaaatgtagctgctgttttgacatta	CRISPR spacer
ggagaaatgtagctgctgttttgacatta	Protospacer
*****************************

3. spacer 2.3|1738356|29|NC_017316|CRISPRCasFinder matches to NZ_CP030046 (Enterococcus faecalis strain C54 plasmid pC54, complete sequence) position: , mismatch: 0, identity: 1.0

ggagaaatgtagctgctgttttgacatta	CRISPR spacer
ggagaaatgtagctgctgttttgacatta	Protospacer
*****************************

4. spacer 2.6|1738554|29|NC_017316|CRISPRCasFinder matches to MK721192 (Enterococcus phage vB_EfaM_Ef2.3, complete genome) position: , mismatch: 0, identity: 1.0

atgcagacattaagaatttaccagaggaa	CRISPR spacer
atgcagacattaagaatttaccagaggaa	Protospacer
*****************************

5. spacer 2.6|1738554|29|NC_017316|CRISPRCasFinder matches to AP018714 (Enterococcus phage phiEF17H DNA, complete sequence) position: , mismatch: 0, identity: 1.0

atgcagacattaagaatttaccagaggaa	CRISPR spacer
atgcagacattaagaatttaccagaggaa	Protospacer
*****************************

6. spacer 2.10|1738356|30|NC_017316|CRT,PILER-CR matches to NZ_CP041739 (Enterococcus faecalis EnGen0107 strain B594 plasmid p1, complete sequence) position: , mismatch: 0, identity: 1.0

ggagaaatgtagctgctgttttgacattag	CRISPR spacer
ggagaaatgtagctgctgttttgacattag	Protospacer
******************************

7. spacer 2.10|1738356|30|NC_017316|CRT,PILER-CR matches to NZ_CP030043 (Enterococcus faecalis strain C25 plasmid pC25-1, complete sequence) position: , mismatch: 0, identity: 1.0

ggagaaatgtagctgctgttttgacattag	CRISPR spacer
ggagaaatgtagctgctgttttgacattag	Protospacer
******************************

8. spacer 2.10|1738356|30|NC_017316|CRT,PILER-CR matches to NZ_CP030046 (Enterococcus faecalis strain C54 plasmid pC54, complete sequence) position: , mismatch: 0, identity: 1.0

ggagaaatgtagctgctgttttgacattag	CRISPR spacer
ggagaaatgtagctgctgttttgacattag	Protospacer
******************************

9. spacer 2.13|1738554|30|NC_017316|CRT,PILER-CR matches to MK721192 (Enterococcus phage vB_EfaM_Ef2.3, complete genome) position: , mismatch: 0, identity: 1.0

atgcagacattaagaatttaccagaggaag	CRISPR spacer
atgcagacattaagaatttaccagaggaag	Protospacer
******************************

10. spacer 2.13|1738554|30|NC_017316|CRT,PILER-CR matches to AP018714 (Enterococcus phage phiEF17H DNA, complete sequence) position: , mismatch: 0, identity: 1.0

atgcagacattaagaatttaccagaggaag	CRISPR spacer
atgcagacattaagaatttaccagaggaag	Protospacer
******************************

11. spacer 2.3|1738356|29|NC_017316|CRISPRCasFinder matches to NZ_CP022484 (Enterococcus faecalis ARO1/DG plasmid pARO1.1, complete sequence) position: , mismatch: 1, identity: 0.966

ggagaaatgtagctgctgttttgacatta	CRISPR spacer
gaagaaatgtagctgctgttttgacatta	Protospacer
*.***************************

12. spacer 2.3|1738356|29|NC_017316|CRISPRCasFinder matches to NZ_CP036248 (Enterococcus faecalis R712 plasmid pR712_02, complete sequence) position: , mismatch: 1, identity: 0.966

ggagaaatgtagctgctgttttgacatta	CRISPR spacer
gaagaaatgtagctgctgttttgacatta	Protospacer
*.***************************

13. spacer 2.3|1738356|29|NC_017316|CRISPRCasFinder matches to NZ_CP042217 (Enterococcus faecalis strain L8 plasmid pL8, complete sequence) position: , mismatch: 1, identity: 0.966

ggagaaatgtagctgctgttttgacatta	CRISPR spacer
gaagaaatgtagctgctgttttgacatta	Protospacer
*.***************************

14. spacer 2.3|1738356|29|NC_017316|CRISPRCasFinder matches to NZ_MK140641 (Enterococcus faecalis strain E035 plasmid pE035, complete sequence) position: , mismatch: 1, identity: 0.966

ggagaaatgtagctgctgttttgacatta	CRISPR spacer
gaagaaatgtagctgctgttttgacatta	Protospacer
*.***************************

15. spacer 2.6|1738554|29|NC_017316|CRISPRCasFinder matches to CAJDJZ010000002 (Enterococcus phage vB_EfaH_149 genome assembly, contig: phage149-genome, whole genome shotgun sequence) position: , mismatch: 1, identity: 0.966

atgcagacattaagaatttaccagaggaa	CRISPR spacer
atgcagacattaagaatttaccagaggga	Protospacer
***************************.*

16. spacer 2.6|1738554|29|NC_017316|CRISPRCasFinder matches to CAJDJY010000002 (Enterococcus phage 156 genome assembly, contig: phage156-genome, whole genome shotgun sequence) position: , mismatch: 1, identity: 0.966

atgcagacattaagaatttaccagaggaa	CRISPR spacer
atgcagacattaagaatttaccagaggga	Protospacer
***************************.*

17. spacer 2.6|1738554|29|NC_017316|CRISPRCasFinder matches to LR031359 (Enterococcus phage 156, complete genome) position: , mismatch: 1, identity: 0.966

atgcagacattaagaatttaccagaggaa	CRISPR spacer
atgcagacattaagaatttaccagaggga	Protospacer
***************************.*

18. spacer 2.10|1738356|30|NC_017316|CRT,PILER-CR matches to NZ_CP022484 (Enterococcus faecalis ARO1/DG plasmid pARO1.1, complete sequence) position: , mismatch: 1, identity: 0.967

ggagaaatgtagctgctgttttgacattag	CRISPR spacer
gaagaaatgtagctgctgttttgacattag	Protospacer
*.****************************

19. spacer 2.10|1738356|30|NC_017316|CRT,PILER-CR matches to NZ_CP036248 (Enterococcus faecalis R712 plasmid pR712_02, complete sequence) position: , mismatch: 1, identity: 0.967

ggagaaatgtagctgctgttttgacattag	CRISPR spacer
gaagaaatgtagctgctgttttgacattag	Protospacer
*.****************************

20. spacer 2.10|1738356|30|NC_017316|CRT,PILER-CR matches to NZ_CP042217 (Enterococcus faecalis strain L8 plasmid pL8, complete sequence) position: , mismatch: 1, identity: 0.967

ggagaaatgtagctgctgttttgacattag	CRISPR spacer
gaagaaatgtagctgctgttttgacattag	Protospacer
*.****************************

21. spacer 2.10|1738356|30|NC_017316|CRT,PILER-CR matches to NZ_MK140641 (Enterococcus faecalis strain E035 plasmid pE035, complete sequence) position: , mismatch: 1, identity: 0.967

ggagaaatgtagctgctgttttgacattag	CRISPR spacer
gaagaaatgtagctgctgttttgacattag	Protospacer
*.****************************

22. spacer 2.13|1738554|30|NC_017316|CRT,PILER-CR matches to CAJDJZ010000002 (Enterococcus phage vB_EfaH_149 genome assembly, contig: phage149-genome, whole genome shotgun sequence) position: , mismatch: 1, identity: 0.967

atgcagacattaagaatttaccagaggaag	CRISPR spacer
atgcagacattaagaatttaccagagggag	Protospacer
***************************.**

23. spacer 2.13|1738554|30|NC_017316|CRT,PILER-CR matches to CAJDJY010000002 (Enterococcus phage 156 genome assembly, contig: phage156-genome, whole genome shotgun sequence) position: , mismatch: 1, identity: 0.967

atgcagacattaagaatttaccagaggaag	CRISPR spacer
atgcagacattaagaatttaccagagggag	Protospacer
***************************.**

24. spacer 2.13|1738554|30|NC_017316|CRT,PILER-CR matches to LR031359 (Enterococcus phage 156, complete genome) position: , mismatch: 1, identity: 0.967

atgcagacattaagaatttaccagaggaag	CRISPR spacer
atgcagacattaagaatttaccagagggag	Protospacer
***************************.**

25. spacer 2.3|1738356|29|NC_017316|CRISPRCasFinder matches to NZ_CP015884 (Enterococcus faecalis strain sorialis plasmid Efsorialis-p1, complete sequence) position: , mismatch: 3, identity: 0.897

ggagaaatgtagctgctgttttgacatta	CRISPR spacer
gaagaaaggtagctgctgttttaacatta	Protospacer
*.***** **************.******

26. spacer 2.10|1738356|30|NC_017316|CRT,PILER-CR matches to NZ_CP015884 (Enterococcus faecalis strain sorialis plasmid Efsorialis-p1, complete sequence) position: , mismatch: 3, identity: 0.9

ggagaaatgtagctgctgttttgacattag	CRISPR spacer
gaagaaaggtagctgctgttttaacattag	Protospacer
*.***** **************.*******

27. spacer 2.1|1738224|29|NC_017316|CRISPRCasFinder matches to NZ_LR214986 (Mycoplasma cynos strain NCTC10142 plasmid 13) position: , mismatch: 5, identity: 0.828

aaattttttgaacttaatgcaatttcttg	CRISPR spacer
aaattttttgctcttaatgcaattacatt	Protospacer
**********  ************ * *

28. spacer 2.8|1738224|30|NC_017316|CRT matches to NZ_LR214986 (Mycoplasma cynos strain NCTC10142 plasmid 13) position: , mismatch: 5, identity: 0.833

aaattttttgaacttaatgcaatttcttga	CRISPR spacer
aaattttttgctcttaatgcaattacatta	Protospacer
**********  ************ * * *

29. spacer 1.1|422523|29|NC_017316|CRISPRCasFinder,CRT matches to NZ_CP012104 (Bacillus thuringiensis strain HS18-1 plasmid pHS18-5, complete sequence) position: , mismatch: 6, identity: 0.793

ttgccacttgcgagcttcaccagagctat	CRISPR spacer
cttccatttgcgagcttcaccagattcat	Protospacer
.* ***.***************** ..**

30. spacer 2.3|1738356|29|NC_017316|CRISPRCasFinder matches to NZ_CP023544 (Campylobacter jejuni strain CFSAN032806 plasmid pCFSAN032806, complete sequence) position: , mismatch: 6, identity: 0.793

ggagaaatgtagctgctgttttgacatta	CRISPR spacer
ggaaaagtgtagctgctgttttgatgctt	Protospacer
***.**.*****************...*

31. spacer 2.3|1738356|29|NC_017316|CRISPRCasFinder matches to NZ_CP017872 (Campylobacter coli strain BP3183 plasmid pCCDM183, complete sequence) position: , mismatch: 6, identity: 0.793

ggagaaatgtagctgctgttttgacatta	CRISPR spacer
ggaaaagtgtagctgctgttttgatgctt	Protospacer
***.**.*****************...*

32. spacer 2.3|1738356|29|NC_017316|CRISPRCasFinder matches to NC_022355 (Campylobacter coli CVM N29710 plasmid pN29710-1, complete sequence) position: , mismatch: 6, identity: 0.793

ggagaaatgtagctgctgttttgacatta	CRISPR spacer
ggaaaagtgtagctgctgttttgatgctt	Protospacer
***.**.*****************...*

33. spacer 2.3|1738356|29|NC_017316|CRISPRCasFinder matches to NZ_CP045793 (Campylobacter coli strain CFSAN032805 plasmid p1CFSAN032805, complete sequence) position: , mismatch: 6, identity: 0.793

ggagaaatgtagctgctgttttgacatta	CRISPR spacer
ggaaaagtgtagctgctgttttgatgctt	Protospacer
***.**.*****************...*

34. spacer 2.3|1738356|29|NC_017316|CRISPRCasFinder matches to NZ_CP023546 (Campylobacter coli strain CFSAN032805 plasmid pCFSAN032805_1, complete sequence) position: , mismatch: 6, identity: 0.793

ggagaaatgtagctgctgttttgacatta	CRISPR spacer
ggaaaagtgtagctgctgttttgatgctt	Protospacer
***.**.*****************...*

35. spacer 2.5|1738488|29|NC_017316|CRISPRCasFinder matches to NZ_CP049227 (Lactobacillus iners strain C0011D1 plasmid pC0011D1, complete sequence) position: , mismatch: 6, identity: 0.793

tggttggatatttttctaataacttacgg	CRISPR spacer
tagttgtatatttttctaataactcctga	Protospacer
*.**** *****************. .*.

36. spacer 2.6|1738554|29|NC_017316|CRISPRCasFinder matches to NC_009929 (Acaryochloris marina MBIC11017 plasmid pREB4, complete sequence) position: , mismatch: 6, identity: 0.793

atgcagacattaagaatttaccagaggaa	CRISPR spacer
aaataggtattaagaatttaccagagaaa	Protospacer
* ..**..******************.**

37. spacer 2.8|1738224|30|NC_017316|CRT matches to NC_019526 (Enterobacteria phage vB_KleM-RaK2, complete genome) position: , mismatch: 6, identity: 0.8

aaattttttgaacttaatgcaat--ttcttga	CRISPR spacer
aaattttttgaacgtaatgccataatcgtt--	Protospacer
************* ****** **  *. **

38. spacer 2.8|1738224|30|NC_017316|CRT matches to MT708547 (Klebsiella phage Muenster, complete genome) position: , mismatch: 6, identity: 0.8

aaattttttgaacttaatgcaat--ttcttga	CRISPR spacer
aaattttttgaacgtaatgccataatcgtt--	Protospacer
************* ****** **  *. **

39. spacer 2.8|1738224|30|NC_017316|CRT matches to AB897757 (Klebsiella phage K64-1 DNA, complete genome) position: , mismatch: 6, identity: 0.8

aaattttttgaacttaatgcaat--ttcttga	CRISPR spacer
aaattttttgaacgtaatgccataatcgtt--	Protospacer
************* ****** **  *. **

40. spacer 2.12|1738488|30|NC_017316|CRT,PILER-CR matches to NZ_CP049227 (Lactobacillus iners strain C0011D1 plasmid pC0011D1, complete sequence) position: , mismatch: 6, identity: 0.8

tggttggatatttttctaataacttacggc	CRISPR spacer
tagttgtatatttttctaataactcctgac	Protospacer
*.**** *****************. .*.*

41. spacer 2.13|1738554|30|NC_017316|CRT,PILER-CR matches to NC_009929 (Acaryochloris marina MBIC11017 plasmid pREB4, complete sequence) position: , mismatch: 6, identity: 0.8

atgcagacattaagaatttaccagaggaag	CRISPR spacer
aaataggtattaagaatttaccagagaaag	Protospacer
* ..**..******************.***

42. spacer 1.4|422721|29|NC_017316|CRISPRCasFinder,CRT matches to HQ906663 (Wolbachia endosymbiont wVitA of Nasonia vitripennis phage WOVitA2, complete sequence) position: , mismatch: 7, identity: 0.759

ttaggtagttttttaacgcacttacttct	CRISPR spacer
gtcctgagttttttgatgcacttacttct	Protospacer
 *    ********.*.************

43. spacer 1.7|422919|29|NC_017316|CRISPRCasFinder,CRT matches to NC_011752 (Escherichia coli 55989 plasmid 55989p, complete sequence) position: , mismatch: 7, identity: 0.759

ctaatgagcattcattacatatgtagaac	CRISPR spacer
aaaatcagcattcattacatatgtaacta	Protospacer
  *** *******************.

44. spacer 1.7|422919|29|NC_017316|CRISPRCasFinder,CRT matches to CP042952 (Escherichia coli strain D8-1 plasmid pD8-1_1, complete sequence) position: , mismatch: 7, identity: 0.759

ctaatgagcattcattacatatgtagaac	CRISPR spacer
aaaatcagcattcattacatatgtaacta	Protospacer
  *** *******************.

45. spacer 1.7|422919|29|NC_017316|CRISPRCasFinder,CRT matches to NZ_CP026724 (Escherichia coli strain 266917_2 plasmid p266917_2_01, complete sequence) position: , mismatch: 7, identity: 0.759

ctaatgagcattcattacatatgtagaac	CRISPR spacer
aaaatcagcattcattacatatgtaacta	Protospacer
  *** *******************.

46. spacer 1.7|422919|29|NC_017316|CRISPRCasFinder,CRT matches to CP051693 (Escherichia coli strain SCU-318 plasmid pSCU-318-1, complete sequence) position: , mismatch: 7, identity: 0.759

ctaatgagcattcattacatatgtagaac	CRISPR spacer
aaaatcagcattcattacatatgtaacta	Protospacer
  *** *******************.

47. spacer 1.7|422919|29|NC_017316|CRISPRCasFinder,CRT matches to NC_019000 (Escherichia coli plasmid pHUSEC41-2, complete sequence) position: , mismatch: 7, identity: 0.759

ctaatgagcattcattacatatgtagaac	CRISPR spacer
aaaatcagcattcattacatatgtaacta	Protospacer
  *** *******************.

48. spacer 1.7|422919|29|NC_017316|CRISPRCasFinder,CRT matches to NZ_CP009053 (Escherichia coli NCCP15648 plasmid p15648-3, complete sequence) position: , mismatch: 7, identity: 0.759

ctaatgagcattcattacatatgtagaac	CRISPR spacer
aaaatcagcattcattacatatgtaacta	Protospacer
  *** *******************.

49. spacer 1.7|422919|29|NC_017316|CRISPRCasFinder,CRT matches to NC_018666 (Escherichia coli O104:H4 str. 2011C-3493 plasmid pAA-EA11, complete sequence) position: , mismatch: 7, identity: 0.759

ctaatgagcattcattacatatgtagaac	CRISPR spacer
aaaatcagcattcattacatatgtaacta	Protospacer
  *** *******************.

50. spacer 1.7|422919|29|NC_017316|CRISPRCasFinder,CRT matches to NC_018662 (Escherichia coli O104:H4 str. 2009EL-2071 plasmid pAA-09EL71, complete sequence) position: , mismatch: 7, identity: 0.759

ctaatgagcattcattacatatgtagaac	CRISPR spacer
aaaatcagcattcattacatatgtaacta	Protospacer
  *** *******************.

51. spacer 1.7|422919|29|NC_017316|CRISPRCasFinder,CRT matches to NZ_CP013186 (Escherichia coli strain FORC_029 plasmid FORC_029p, complete sequence) position: , mismatch: 7, identity: 0.759

ctaatgagcattcattacatatgtagaac	CRISPR spacer
aaaatcagcattcattacatatgtaacta	Protospacer
  *** *******************.

52. spacer 1.7|422919|29|NC_017316|CRISPRCasFinder,CRT matches to NZ_CP022087 (Escherichia coli O104:H4 strain FDAARGOS_348 plasmid unnamed2, complete sequence) position: , mismatch: 7, identity: 0.759

ctaatgagcattcattacatatgtagaac	CRISPR spacer
aaaatcagcattcattacatatgtaacta	Protospacer
  *** *******************.

53. spacer 1.7|422919|29|NC_017316|CRISPRCasFinder,CRT matches to CP049615 (Escherichia coli O157:H7 strain K1516 plasmid pK1516-3, complete sequence) position: , mismatch: 7, identity: 0.759

ctaatgagcattcattacatatgtagaac	CRISPR spacer
aaaatcagcattcattacatatgtaacta	Protospacer
  *** *******************.

54. spacer 1.7|422919|29|NC_017316|CRISPRCasFinder,CRT matches to NC_022743 (Escherichia coli plasmid pHUSEC2011-2, complete sequence) position: , mismatch: 7, identity: 0.759

ctaatgagcattcattacatatgtagaac	CRISPR spacer
aaaatcagcattcattacatatgtaacta	Protospacer
  *** *******************.

55. spacer 1.7|422919|29|NC_017316|CRISPRCasFinder,CRT matches to NZ_CP031904 (Escherichia coli O104:H4 strain FWSEC0009 plasmid unnamed19, complete sequence) position: , mismatch: 7, identity: 0.759

ctaatgagcattcattacatatgtagaac	CRISPR spacer
aaaatcagcattcattacatatgtaacta	Protospacer
  *** *******************.

56. spacer 1.7|422919|29|NC_017316|CRISPRCasFinder,CRT matches to NC_018654 (Escherichia coli O104:H4 str. 2009EL-2050 plasmid pAA-09EL50, complete sequence) position: , mismatch: 7, identity: 0.759

ctaatgagcattcattacatatgtagaac	CRISPR spacer
aaaatcagcattcattacatatgtaacta	Protospacer
  *** *******************.

57. spacer 1.7|422919|29|NC_017316|CRISPRCasFinder,CRT matches to NZ_CP023530 (Escherichia coli strain FDAARGOS_401 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.759

ctaatgagcattcattacatatgtagaac	CRISPR spacer
aaaatcagcattcattacatatgtaacta	Protospacer
  *** *******************.

58. spacer 1.7|422919|29|NC_017316|CRISPRCasFinder,CRT matches to NZ_CP041001 (Escherichia coli strain FDAARGOS_772 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.759

ctaatgagcattcattacatatgtagaac	CRISPR spacer
aaaatcagcattcattacatatgtaacta	Protospacer
  *** *******************.

59. spacer 1.7|422919|29|NC_017316|CRISPRCasFinder,CRT matches to CP025574 (Escherichia coli strain E-1246 plasmid pE1246_1, complete sequence) position: , mismatch: 7, identity: 0.759

ctaatgagcattcattacatatgtagaac	CRISPR spacer
aaaatcagcattcattacatatgtaacta	Protospacer
  *** *******************.

60. spacer 1.7|422919|29|NC_017316|CRISPRCasFinder,CRT matches to NZ_CP023533 (Escherichia coli strain FDAARGOS_403 plasmid unnamed2, complete sequence) position: , mismatch: 7, identity: 0.759

ctaatgagcattcattacatatgtagaac	CRISPR spacer
aaaatcagcattcattacatatgtaacta	Protospacer
  *** *******************.

61. spacer 1.7|422919|29|NC_017316|CRISPRCasFinder,CRT matches to NZ_CP027392 (Escherichia coli O104:H4 strain FDAARGOS_349 plasmid unnamed2, complete sequence) position: , mismatch: 7, identity: 0.759

ctaatgagcattcattacatatgtagaac	CRISPR spacer
aaaatcagcattcattacatatgtaacta	Protospacer
  *** *******************.

62. spacer 1.7|422919|29|NC_017316|CRISPRCasFinder,CRT matches to NZ_CP023062 (Escherichia coli strain FORC_069 plasmid pFORC69, complete sequence) position: , mismatch: 7, identity: 0.759

ctaatgagcattcattacatatgtagaac	CRISPR spacer
aaaatcagcattcattacatatgtaacta	Protospacer
  *** *******************.

63. spacer 1.7|422919|29|NC_017316|CRISPRCasFinder,CRT matches to NZ_CP023552 (Escherichia coli strain FORC_043 plasmid pFORC43, complete sequence) position: , mismatch: 7, identity: 0.759

ctaatgagcattcattacatatgtagaac	CRISPR spacer
aaaatcagcattcattacatatgtaacta	Protospacer
  *** *******************.

64. spacer 1.7|422919|29|NC_017316|CRISPRCasFinder,CRT matches to NZ_KY706108 (Escherichia coli strain pAA-ST131 plasmid ESBL20150001, complete sequence) position: , mismatch: 7, identity: 0.759

ctaatgagcattcattacatatgtagaac	CRISPR spacer
aaaatcagcattcattacatatgtaacta	Protospacer
  *** *******************.

65. spacer 1.7|422919|29|NC_017316|CRISPRCasFinder,CRT matches to NZ_CP031270 (Staphylococcus warneri strain 16A plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.759

ctaatgagcattcattacatatgtagaac	CRISPR spacer
taaatgagcattcattacttatatacatt	Protospacer
. **************** ***.** * .

66. spacer 1.7|422919|29|NC_017316|CRISPRCasFinder,CRT matches to NZ_CP031270 (Staphylococcus warneri strain 16A plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.759

ctaatgagcattcattacatatgtagaac	CRISPR spacer
taaatgagcattcattacttatatacatt	Protospacer
. **************** ***.** * .

67. spacer 1.8|422720|30|NC_017316|PILER-CR matches to HQ906663 (Wolbachia endosymbiont wVitA of Nasonia vitripennis phage WOVitA2, complete sequence) position: , mismatch: 7, identity: 0.767

tttaggt----agttttttaacgcacttacttct	CRISPR spacer
----agtcctgagttttttgatgcacttacttct	Protospacer
    .**    ********.*.************

68. spacer 2.2|1738290|29|NC_017316|CRISPRCasFinder matches to NC_009453 (Arthrobacter sp. Rue61a plasmid pAL1, complete sequence) position: , mismatch: 7, identity: 0.759

aaaacttttgacggctctttagtcaaccc	CRISPR spacer
gcattttttgacggctctgaagtcaaccg	Protospacer
. * .*************  ********

69. spacer 2.5|1738488|29|NC_017316|CRISPRCasFinder matches to NC_019526 (Enterobacteria phage vB_KleM-RaK2, complete genome) position: , mismatch: 7, identity: 0.759

tggttggatatttttctaataacttacgg	CRISPR spacer
tatctggatatttttctaataaaatacta	Protospacer
*. .******************  *** .

70. spacer 2.5|1738488|29|NC_017316|CRISPRCasFinder matches to MT708547 (Klebsiella phage Muenster, complete genome) position: , mismatch: 7, identity: 0.759

tggttggatatttttctaataacttacgg	CRISPR spacer
tatctggatatttttctaataaaatacta	Protospacer
*. .******************  *** .

71. spacer 2.5|1738488|29|NC_017316|CRISPRCasFinder matches to AB897757 (Klebsiella phage K64-1 DNA, complete genome) position: , mismatch: 7, identity: 0.759

tggttggatatttttctaataacttacgg	CRISPR spacer
tatctggatatttttctaataaaatacta	Protospacer
*. .******************  *** .

72. spacer 2.10|1738356|30|NC_017316|CRT,PILER-CR matches to NZ_CP023544 (Campylobacter jejuni strain CFSAN032806 plasmid pCFSAN032806, complete sequence) position: , mismatch: 7, identity: 0.767

ggagaaatgtagctgctgttttgacattag	CRISPR spacer
ggaaaagtgtagctgctgttttgatgcttt	Protospacer
***.**.*****************...*

73. spacer 2.10|1738356|30|NC_017316|CRT,PILER-CR matches to NZ_CP017872 (Campylobacter coli strain BP3183 plasmid pCCDM183, complete sequence) position: , mismatch: 7, identity: 0.767

ggagaaatgtagctgctgttttgacattag	CRISPR spacer
ggaaaagtgtagctgctgttttgatgcttt	Protospacer
***.**.*****************...*

74. spacer 2.10|1738356|30|NC_017316|CRT,PILER-CR matches to NC_022355 (Campylobacter coli CVM N29710 plasmid pN29710-1, complete sequence) position: , mismatch: 7, identity: 0.767

ggagaaatgtagctgctgttttgacattag	CRISPR spacer
ggaaaagtgtagctgctgttttgatgcttt	Protospacer
***.**.*****************...*

75. spacer 2.10|1738356|30|NC_017316|CRT,PILER-CR matches to NZ_CP045793 (Campylobacter coli strain CFSAN032805 plasmid p1CFSAN032805, complete sequence) position: , mismatch: 7, identity: 0.767

ggagaaatgtagctgctgttttgacattag	CRISPR spacer
ggaaaagtgtagctgctgttttgatgcttt	Protospacer
***.**.*****************...*

76. spacer 2.10|1738356|30|NC_017316|CRT,PILER-CR matches to NZ_CP023546 (Campylobacter coli strain CFSAN032805 plasmid pCFSAN032805_1, complete sequence) position: , mismatch: 7, identity: 0.767

ggagaaatgtagctgctgttttgacattag	CRISPR spacer
ggaaaagtgtagctgctgttttgatgcttt	Protospacer
***.**.*****************...*

77. spacer 1.4|422721|29|NC_017316|CRISPRCasFinder,CRT matches to AB161975 (Wolbachia phage WOcauB1 genomic DNA, partial sequence) position: , mismatch: 8, identity: 0.724

ttaggtagttttttaacgcacttacttct	CRISPR spacer
gccctgagttttttgatgcacttacttct	Protospacer
 .    ********.*.************

78. spacer 1.7|422919|29|NC_017316|CRISPRCasFinder,CRT matches to KU886273 (Freshwater phage uvFW-CGR-AMD-COM-C455, complete genome) position: , mismatch: 8, identity: 0.724

ctaatgagcattcattacatatgtagaac	CRISPR spacer
tgggctagtattcattacaaatgtagaac	Protospacer
. ... **.********** *********

79. spacer 1.8|422720|30|NC_017316|PILER-CR matches to AB161975 (Wolbachia phage WOcauB1 genomic DNA, partial sequence) position: , mismatch: 8, identity: 0.733

---tttaggtagttttttaacgcacttacttct	CRISPR spacer
agccctg---agttttttgatgcacttacttct	Protospacer
   ..*.   ********.*.************

80. spacer 2.1|1738224|29|NC_017316|CRISPRCasFinder matches to NC_019526 (Enterobacteria phage vB_KleM-RaK2, complete genome) position: , mismatch: 8, identity: 0.724

aaattttttgaacttaatgcaatttcttg	CRISPR spacer
aaattttttgaacgtaatgccataatcgt	Protospacer
************* ****** **  ..

81. spacer 2.1|1738224|29|NC_017316|CRISPRCasFinder matches to MT708547 (Klebsiella phage Muenster, complete genome) position: , mismatch: 8, identity: 0.724

aaattttttgaacttaatgcaatttcttg	CRISPR spacer
aaattttttgaacgtaatgccataatcgt	Protospacer
************* ****** **  ..

82. spacer 2.1|1738224|29|NC_017316|CRISPRCasFinder matches to AB897757 (Klebsiella phage K64-1 DNA, complete genome) position: , mismatch: 8, identity: 0.724

aaattttttgaacttaatgcaatttcttg	CRISPR spacer
aaattttttgaacgtaatgccataatcgt	Protospacer
************* ****** **  ..

83. spacer 2.5|1738488|29|NC_017316|CRISPRCasFinder matches to NZ_AP019717 (Clostridium butyricum strain NBRC 13949 plasmid pCBU1, complete sequence) position: , mismatch: 8, identity: 0.724

tggttggatatttttctaataacttacgg	CRISPR spacer
gagtttgatatttttctaataatttttta	Protospacer
 .*** ****************.** . .

84. spacer 2.9|1738290|30|NC_017316|CRT,PILER-CR matches to NC_009453 (Arthrobacter sp. Rue61a plasmid pAL1, complete sequence) position: , mismatch: 8, identity: 0.733

aaaacttttgacggctctttagtcaaccca	CRISPR spacer
gcattttttgacggctctgaagtcaaccgt	Protospacer
. * .*************  ********

85. spacer 2.12|1738488|30|NC_017316|CRT,PILER-CR matches to NC_019526 (Enterobacteria phage vB_KleM-RaK2, complete genome) position: , mismatch: 8, identity: 0.733

tggttggatatttttctaataacttacggc	CRISPR spacer
tatctggatatttttctaataaaatactaa	Protospacer
*. .******************  *** .

86. spacer 2.12|1738488|30|NC_017316|CRT,PILER-CR matches to MT708547 (Klebsiella phage Muenster, complete genome) position: , mismatch: 8, identity: 0.733

tggttggatatttttctaataacttacggc	CRISPR spacer
tatctggatatttttctaataaaatactaa	Protospacer
*. .******************  *** .

87. spacer 2.12|1738488|30|NC_017316|CRT,PILER-CR matches to AB897757 (Klebsiella phage K64-1 DNA, complete genome) position: , mismatch: 8, identity: 0.733

tggttggatatttttctaataacttacggc	CRISPR spacer
tatctggatatttttctaataaaatactaa	Protospacer
*. .******************  *** .

88. spacer 2.12|1738488|30|NC_017316|CRT,PILER-CR matches to NZ_AP019717 (Clostridium butyricum strain NBRC 13949 plasmid pCBU1, complete sequence) position: , mismatch: 9, identity: 0.7

tggttggatatttttctaataacttacggc	CRISPR spacer
gagtttgatatttttctaataattttttag	Protospacer
 .*** ****************.** . .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

828707 : 834299

Streptococcus_phage(85.71%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002413734.1\|828707_829034_+	YdcP family protein	A0A1S5SF38	Streptococcus_phage	1.9e-27	57.3
WP_002413735.1\|829036_829411_+	YdcP family protein	A0A1S5SF96	Streptococcus_phage	3.0e-32	60.5
WP_002413736.1\|829410_830766_+	DUF87 domain-containing protein	A0A1S5SFB5	Streptococcus_phage	2.4e-148	60.3
WP_002413737.1\|830777_831782_+	DNA cytosine methyltransferase	A0A218MND0	uncultured_virus	2.5e-118	64.2
WP_002413738.1\|831798_832119_+	hypothetical protein	NA	NA	NA	NA
WP_014524976.1\|832351_833539_+	helix-turn-helix domain-containing protein	A0A1S5SEX3	Streptococcus_phage	9.2e-144	62.9
WP_002408635.1\|833556_833778_+	hypothetical protein	A0A1S5SEY0	Streptococcus_phage	1.2e-28	90.4
WP_002413740.1\|833798_834299_+	antirestriction protein ArdA	A0A1S5SF25	Streptococcus_phage	1.5e-47	57.2

DBSCAN-SWA_2

1087720 : 1105492

Enterococcus_phage(42.86%)

holin,tail

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002413353.1\|1087720_1090117_+	translation initiation factor IF-2	A0A2H4UTS4	Bodo_saltans_virus	1.7e-19	24.1
WP_002360497.1\|1090141_1090492_+	30S ribosome-binding factor RbfA	NA	NA	NA	NA
WP_002357857.1\|1090864_1091338_-	toxin	A0A097BY56	Enterococcus_phage	1.1e-60	71.2
WP_002360496.1\|1091384_1091867_-	helix-turn-helix domain-containing protein	R9QTP6	Staphylococcus_phage	2.6e-20	47.7
WP_073459191.1\|1092035_1092218_+	hypothetical protein	NA	NA	NA	NA
WP_002413352.1\|1092248_1093019_+	DnaD domain protein	A0A0K0MX39	Streptococcus_phage	2.5e-33	57.0
WP_002379370.1\|1093037_1093880_+	ATP-binding protein	A0A0P0I3L9	Lactobacillus_phage	5.7e-31	31.0
WP_010706586.1\|1093882_1093975_+	hypothetical protein	NA	NA	NA	NA
WP_002413351.1\|1093967_1094339_+	hypothetical protein	NA	NA	NA	NA
WP_002379371.1\|1094358_1094766_+	RinA family phage transcriptional activator	NA	NA	NA	NA
WP_002413349.1\|1095011_1095404_+	structural protein	NA	NA	NA	NA
WP_002397214.1\|1095416_1095929_+\|tail	phage major tail protein, TP901-1 family	W6LP72	Streptococcus_phage	6.7e-35	49.4
WP_002413348.1\|1095961_1096321_+	hypothetical protein	A0A0F6N4J9	Staphylococcus_phage	9.9e-09	29.8
WP_002365551.1\|1096338_1096707_+	hypothetical protein	A0A1P8BLR3	Lactococcus_phage	1.7e-08	33.3
WP_002413347.1\|1096696_1099630_+	hypothetical protein	A0A1U9WR55	Streptococcus_virus	1.1e-09	25.0
WP_002413346.1\|1099631_1100558_+\|tail	phage tail family protein	C9E2K5	Enterococcus_phage	2.6e-146	78.2
WP_002413345.1\|1100570_1102028_+	structural protein	C9E2K6	Enterococcus_phage	5.0e-176	48.0
WP_002394389.1\|1102060_1103830_+	hypothetical protein	A0A097BYA8	Enterococcus_phage	2.1e-144	72.5
WP_002394390.1\|1103853_1104249_+\|holin	phage holin family protein	F0PIJ6	Enterococcus_phage	6.3e-33	48.9
WP_002413343.1\|1104394_1105492_+	endolysin	A0A139ZVY1	Enterococcus_phage	3.1e-77	44.6

DBSCAN-SWA_3

1547793 : 1556437

Synechococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002414018.1\|1547793_1548366_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	3.2e-25	35.1
WP_002414017.1\|1548362_1549394_-	phosphoribosylformylglycinamidine cyclo-ligase	A0A1D8KMR0	Synechococcus_phage	1.6e-56	45.2
WP_002385863.1\|1549395_1550835_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	6.1e-49	32.1
WP_002414015.1\|1550810_1553030_-	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	2.2e-146	39.8
WP_002357272.1\|1553026_1553701_-	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_002357271.1\|1553701_1553953_-	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_002407785.1\|1553966_1554680_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A0E3ELR0	Synechococcus_phage	8.7e-49	43.4
WP_002414014.1\|1554831_1555956_-	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
WP_002378405.1\|1555948_1556437_-	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	8.4e-19	42.0

DBSCAN-SWA_4

2237957 : 2247698

Streptococcus_phage(57.14%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002385686.1\|2237957_2240141_+	anaerobic ribonucleoside-triphosphate reductase	A0A0C5KKX3	Enterococcus_phage	3.1e-286	66.8
WP_002356379.1\|2240173_2240770_+	anaerobic ribonucleoside-triphosphate reductase activating protein	A0A0C5K925	Enterococcus_phage	6.0e-51	56.4
WP_002362328.1\|2240814_2241933_-	DNA polymerase IV	NA	NA	NA	NA
WP_002356377.1\|2242058_2242817_-	iron export ABC transporter permease subunit FetB	NA	NA	NA	NA
WP_002356375.1\|2242800_2243463_-	ATP-binding cassette domain-containing protein	G3M9Y6	Bacillus_virus	6.7e-19	31.1
WP_002356373.1\|2243477_2244350_-	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	6.2e-81	57.6
WP_002356372.1\|2244462_2244810_-	DNA replication initiation control protein YabA	M1PFV3	Streptococcus_phage	8.1e-16	36.7
WP_002356371.1\|2244802_2245642_-	stage 0 sporulation family protein	NA	NA	NA	NA
WP_002384059.1\|2245758_2246709_-	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	6.2e-34	33.0
WP_002356367.1\|2246710_2247040_-	hypothetical protein	NA	NA	NA	NA
WP_002356366.1\|2247059_2247698_-	dTMP kinase	M1PSC7	Streptococcus_phage	2.1e-54	53.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_017316

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CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection