CRISPRimmunity

Please click to download your results

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Target MGE spacer number	Prophage number
NC_015657	Candidatus Frankia datiscae plasmid pFSYMDG02, complete sequence	0 crisprs	NA	0	0
NC_015664	Candidatus Frankia datiscae plasmid pFSYMDG01, complete sequence	0 crisprs	NA	0	0
NC_015656	Candidatus Frankia datiscae, complete sequence	11 crisprs	RT,csa3,cas3,cas6,cas4,DEDDh,WYL,cas3HD,c2c9_V-U4	3	6

Results visualization

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NC_015656_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015656_1

303167-303264

Orphan

Consensus_repeat	Method
GTTGGTGTGGCGGCTGGCGCCGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015656_1

>merge|NC_015656|1|303167-303264|CRISPRCasFinder
GTTGGTGTGGCGGCTGGCGCCGCCCCACACGGTGGCTTGCTGGTGTGGCGGCCAGCGCCGCCACAGGCGGCTTCGTTGGTGTGGCGGCCGGCGCCGCC

>NC_015656|1|1|303167-303264|CRISPRCasFinder
GTTGGTGTGGCGGCTGGCGCCGCC	CCACACGGTGGCTTGCTGGTGTGGCGGCCAGCGCCGCCACAGGCGGCTTC
GTTGGTGTGGCGGCCGGCGCCGCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015656.1\|WP_013871802.1\|293603_293771_-\|hypothetical-protein	unknown	unknown	unknown
NC_015656.1\|WP_013871803.1\|294480_295395_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NC_015656.1\|WP_085948576.1\|295603_296575_+\|dihydropteroate-synthase	unknown	unknown	gnl\|CDD\|238380
NC_015656.1\|WP_013871812.1\|303302_304160_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377524
NC_015656.1\|WP_043604398.1\|305618_306245_+\|UdgX-family-uracil-DNA-binding-protein	unknown	unknown	gnl\|CDD\|274850
NC_015656.1\|WP_131772014.1\|300903_301947_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|226040
NC_015656.1\|WP_013871651.1\|291980_293417_+\|IS66-family-transposase	unknown	unknown	gnl\|CDD\|376980
NC_015656.1\|WP_013871819.1\|310536_311655_+\|phosphoserine-transaminase	unknown	unknown	gnl\|CDD\|235103
NC_015656.1\|WP_013871821.1\|313628_314633_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381313
NC_015656.1\|WP_013871805.1\|296571_297027_+\|dihydroneopterin-aldolase	unknown	unknown	gnl\|CDD\|376737
NC_015656.1\|WP_013871807.1\|297640_298078_+\|DUF3180-domain-containing-protein	unknown	unknown	gnl\|CDD\|378650
NC_015656.1\|WP_083828077.1\|297023_297644_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	unknown	unknown	gnl\|CDD\|223872
NC_015656.1\|WP_043604402.1\|309449_310544_+\|citrate-synthase-2	unknown	unknown	gnl\|CDD\|237070
NC_015656.1\|WP_131772017.1\|308298_309102_-\|pyridoxamine-5'-phosphate-oxidase	unknown	unknown	gnl\|CDD\|273138
NC_015656.1\|WP_131772015.1\|306368_307247_-\|L,D-transpeptidase	unknown	unknown	gnl\|CDD\|341130
NC_015656.1\|WP_131772013.1\|304624_305329_-\|hypothetical-protein	unknown	unknown	unknown
NC_015656.1\|WP_013871801.1\|291386_291680_+\|hypothetical-protein	unknown	unknown	unknown
NC_015656.1\|WP_131773795.1\|307318_307879_-\|hypothetical-protein	unknown	unknown	unknown
NC_015656.1\|WP_013871820.1\|311846_313214_-\|citrate-synthase	unknown	unknown	gnl\|CDD\|99869
NC_015656.1\|WP_013871809.1\|299855_300455_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_015656.1\|WP_131772017.1\|308298_309102_-\|pyridoxamine-5'-phosphate-oxidase	gnl\|CDD\|273138	TIGR00558, Pyridoxine/pyridoxamine_5'-phosphate_oxidase, pyridoxamine-phosphate oxidase. This model is similar to Pyridox_oxidase from Pfam but is designed to find only true pyridoxamine-phosphate oxidase and to ignore the related protein PhzG involved in phenazine biosynthesis. This protein from E. coli was characterized as a homodimer with two FMN per dimer. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridoxine].	4.4028e-97
NC_015656.1\|WP_013871803.1\|294480_295395_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.87019e-11
NC_015656.1\|WP_131772015.1\|306368_307247_-\|L,D-transpeptidase	gnl\|CDD\|341130	cd16913, YkuD_like, L,D-transpeptidases/carboxypeptidases similar to Bacillus YkuD. Members of the YkuD-like family of proteins are found in a range of bacteria. The best studied member Bacillus YkuD has been shown to act as an L,D-transpeptidase that gives rise to an alternative pathway for peptidoglycan cross-linking. Another member Helicobacter pylori Csd6 functions as an L,D-carboxypeptidase and regulates helical cell shape and motility. The conserved region contains a conserved histidine and cysteine, with the cysteine thought to be an active site residue.	3.9654e-29
NC_015656.1\|WP_013871812.1\|303302_304160_-\|hypothetical-protein	gnl\|CDD\|377524	pfam05552, TM_helix, Conserved TM helix. This alignment represents a conserved transmembrane helix as well as some flanking sequence. It is often found in association with pfam00924.	3.68391e-06
NC_015656.1\|WP_043604398.1\|305618_306245_+\|UdgX-family-uracil-DNA-binding-protein	gnl\|CDD\|274850	TIGR03914, SPO1_DNA_polymerase-related_protein, uracil-DNA glycosylase family domain. This model represents a clade within the uracil-DNA glycosylase superfamily. Among characterized proteins, it most closely resembles the Thermus thermophilus uracil-DNA glycosylase TTUDGA, which acts uracil (deamidated cytosine) in both single-stranded DNA and U/G pairs of double-stranded DNA. This domain may occur either as a stand-alone protein or as the C-terminal domain of a fusion with another domain that always pairs with a particular radical-SAM family protein.	7.83054e-80
NC_015656.1\|WP_131772014.1\|300903_301947_-\|alpha/beta-hydrolase	gnl\|CDD\|226040	COG3509, LpqC, Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism].	3.0674e-28
NC_015656.1\|WP_013871651.1\|291980_293417_+\|IS66-family-transposase	gnl\|CDD\|376980	pfam03050, DDE_Tnp_IS66, Transposase IS66 family. Transposase proteins are necessary for efficient DNA transposition. This family includes IS66 from Agrobacterium tumefaciens.	1.17483e-57
NC_015656.1\|WP_013871819.1\|310536_311655_+\|phosphoserine-transaminase	gnl\|CDD\|235103	PRK03080, PRK03080, phosphoserine transaminase.	0
NC_015656.1\|WP_013871821.1\|313628_314633_+\|aldo/keto-reductase	gnl\|CDD\|381313	cd19087, AKR_AKR12A1_B1_C1, AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR). Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.	4.76557e-104
NC_015656.1\|WP_013871805.1\|296571_297027_+\|dihydroneopterin-aldolase	gnl\|CDD\|376737	pfam02152, FolB, Dihydroneopterin aldolase. This enzyme EC:4.1.2.25 catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin in the biosynthetic pathway of tetrahydrofolate.	2.61908e-44
NC_015656.1\|WP_013871807.1\|297640_298078_+\|DUF3180-domain-containing-protein	gnl\|CDD\|378650	pfam11377, DUF3180, Protein of unknown function (DUF3180). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.	5.36809e-26
NC_015656.1\|WP_083828077.1\|297023_297644_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	gnl\|CDD\|223872	COG0801, FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [Coenzyme metabolism].	3.05604e-56
NC_015656.1\|WP_043604402.1\|309449_310544_+\|citrate-synthase-2	gnl\|CDD\|237070	PRK12350, PRK12350, citrate synthase 2; Provisional.	0
NC_015656.1\|WP_085948576.1\|295603_296575_+\|dihydropteroate-synthase	gnl\|CDD\|238380	cd00739, DHPS, DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and protein biosynthesis. Prokaryotes (and some lower eukaryotes) must synthesize folate de novo, while higher eukaryotes are able to utilize dietary folate and therefore lack DHPS. Sulfonamide drugs, which are substrate analogs of pABA, target DHPS.	6.48995e-100
NC_015656.1\|WP_013871820.1\|311846_313214_-\|citrate-synthase	gnl\|CDD\|99869	cd06116, CaCS_like, Chloroflexus aurantiacus (Ca) citrate synthase (CS)_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). This group is similar to gram-negative Escherichia coli (Ec) CS (type II, gltA) and Arabidopsis thaliana (Ath) peroxisomal (Per) CS. However EcCS and AthPerCS are not found in this group. The overall CS reaction is thought to proceed through three partial reactions and involves both closed and open conformational forms of the enzyme: a) the carbanion or equivalent is generated from AcCoA by base abstraction of a proton, b) the nucleophilic attack of this carbanion on OAA to generate citryl-CoA, and c) the hydrolysis of citryl-CoA to produce citrate and CoA. There are two types of CSs: type I CS and type II CSs. Type I CSs are found in eukarya, gram-positive bacteria, archaea, and in some gram-negative bacteria and are homodimers with both subunits participating in the active site. Type II CSs are unique to gram-negative bacteria and are homohexamers of identical subunits (approximated as a trimer of dimers). Some type II CSs are strongly and specifically inhibited by NADH through an allosteric mechanism. C. aurantiacus is a gram-negative thermophilic green gliding bacterium, its CS belonging to this group may be a type I CS; it is not inhibited by NADH or 2-oxoglutarate and is inhibited by ATP. Both gram-positive and gram-negative bacteria are found in this group.	0

>NC_015656.1|WP_131772014.1|300903_301947_-|alpha/beta-hydrolase
MITVSTPTTGPDAYERSGRTTQLRLTLPAITITRPFPLVIALHSLNNDSSEPQSLWGFDVLVGTAGFAVAYPDALNTSWNAGTCCGQSAAAQVDDVGWLRALISHLEQHYPIDRQRVFLVGFSNGGMIAYRYACEHADEIAGIAVVAASLQTAGCAPAKPVTVVAIHGQLDKRVPYAGEAWSEALGTPLRSARESLSPFRASAGCAEPSLPQDTFTVGSDGGAIGNAAGGQLVGLDEDGAAGPASRGGGAQQAAPGQAVAALAPPAGAGGRTATSGPGVGAALAARDGYTAIRQETVCSSGKRIVEFLLPGLAHGWPPATGPKRFDTAAVIWRLLAPMRSPAPGPDL
>NC_015656.1|WP_013871809.1|299855_300455_+|hypothetical-protein
MAEDQRWWGRRCGRRHGPALRGVRRPGRRHRGTRSVREPAAGHAAPPATVPADWVAVTDAQQKAAFSHPAAWQQRRDKTAVFFVEPPVGNARSGGPQMVGVARVAGTDQAAALTAVQDSEFTIQPGVTRETTRTVADPGGARVQEWVGSYLREGQRATYVMRAVPAGDAVYVLIARSSAQSAATATTLLESLRASFRPA
>NC_015656.1|WP_013871807.1|297640_298078_+|DUF3180-domain-containing-protein
MRPTRARELVAAAVVVGVLAYVLLAFTYRDLPRFPRTAPLSLLIVGLAEAQTAAITRRRLQGRPGTRPILPLTVARLAALAKASSLAGAALMGAWAALLGYALPRLDEFGTADTDAVTAGLGVAAALVLLVSGLLLERVCRVPKS
>NC_015656.1|WP_083828077.1|297023_297644_+|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase
MSGATGPHRPQDASGPGPQPRPQEQRPPGRPSPGRRRPGSLARRPTPAGQAPAVLALGSNLGDRLAQLRAATRLLGSVAVSPVYETAPVGGPDQDDYLNAVVLVPAAPPRDLLAAARSAERAAHRARTVRWGPRTLDVDVIACGDLVSDDPDILIPHPRAHLRAFVCVPWLDVDPDAALPGHGRVEELVAALDTSGVRRTPWSLSG
>NC_015656.1|WP_013871805.1|296571_297027_+|dihydroneopterin-aldolase
MTSTSPDTSAGTSLTASSATAAVSPAAALVASGRIAVTGLRVRGHHGVLPAECELGQEFVVDAAVWLDTRPAAASDDVAATVDYGTLAQTLAGIVAGEPVNLIETLAHRLADACLADDRVLRAEVTVHKPAAPIPLPFTDVAVTVTRSRRA
>NC_015656.1|WP_085948576.1|295603_296575_+|dihydropteroate-synthase
MGVVNVTPDSFSDGGAYPTAVDAVRAGLAMAAEGADIVDVGGESTRPGAGRVDPAEELRRVLPVVTELAAAGVAVSVDTTRPAVAEAALAAGAAVINDVSGAADRDLLAVAAERAVPYVLMHTRGVSADMATRAVYGDVVSEVVAELRERLDAVFAAGIAPERVIVDPGIGFAKESGHNWTLLAHLDAIAALGHPLLVGTSRKSFLGSLLADADERPRPAGERDDATQATTALLAADGVWAVRVHAVRAAADAVRVVQAWREARERRAWPAGGGPAPAERTPARPDSAVSDPGRSNPGTSDPGVTDPGVSARGAFRLPPTSAV
>NC_015656.1|WP_013871803.1|294480_295395_+|GNAT-family-N-acetyltransferase
MAAEPVGDPGQPAAAPDALVAPTVGEPVDGDLSRELEDLAHRAWPPLRERRLGGWVLRESAGSSRRGNSVWARGDVGDIAGALNAVGEFYATAGLPPTLQITPVSLPADIHEALDVAGFDDTGPTDVCVADLEEIRERLAAGPTGHVPVGAGGSPSADADGHRAILLDTVGDVWLDVAGQVLATFAGQRAGTLGVLANLTVPAAYVLCVLDGVPVAVGRGTVDGDWLGIYSMATVPAARGRGAAHAVLARLAAWAAEAGASRAYLQVEQTSTAARRLYAAIGFRPVYRYSYRRLHTAAAPGVSG
>NC_015656.1|WP_013871802.1|293603_293771_-|hypothetical-protein
MSRLVTLVAAVDAQPTLEQTDSMLIELGQMPRNAVVLGLIDALLEYRTLLVSLTS
>NC_015656.1|WP_013871651.1|291980_293417_+|IS66-family-transposase
MSDGPPASPPVPSYDELAALVVSLRAQLVETAAALEQARVRIAELEAQVAKNSRNSAKPPSSDGLAKPPPKSLRKKTGRRPGGQGGHPGSTLRMLAEPDVRLRHEPGPCAGCGAGLAGRPVTRTERRQVFDLPELRPHVVEHQLIERECGCGTRTKAAAPAGVDAPVQYGPRVAAAVVYLYSGQFLSQERTATALAELVGIPISAGTVGAMTARAAAGLDGFRDTVRGLLAAADVIGADETGLRVAGKLHWVHCARTDKYTLIDCHATRGSGGIDALGVLPAFGGVVVHDAWAPYDSYTGATHQLCVAHVLRELQAVVDAAPTGTWCWAAQAGDALVALHRLAVDAATTGVTIDEQAPATQTRQLRHAAHIGISQTSPRGTKLMAARHALACRLVDREADYLRFTRDWRVPADNNGSERDIRMIKLRQKVSGCLRTLTGARQFCAIRSYLSTATKHGISLFDALVQLAEGRPWMPAIS
>NC_015656.1|WP_013871801.1|291386_291680_+|hypothetical-protein
MAQQQQQQQIEQELRQNWQQIRYRLLDEFGQVGTADLDAARDVNDLVQRIADKTHHSERYVETRLQELVGVGAAGQRGQQQGGFGQQQGQQGQRFGR
>NC_015656.1|WP_013871812.1|303302_304160_-|hypothetical-protein
MVPQAAGWDQGVRDAWTSVIQSVPKIGAFVLILLAGGLAARGIVSAVNRLLVRAGADNLLDRSGLARMLRRPAADLRADLMRITFAIAALALLQLALGVFGVNPVSILVHDLIVMLARAVLACVVLVIGATLASAARGYVGNALSGLPYAGAAGVVSATIIMIGFGKAALDELGLATSVTTPMLYAVLATITGVTIVGVGGGLIRPMQQRWEEALRRGGQELTSARSTWHGNRARSAAEEPMVVSVSDLVASGRTGRRPDTPPDPLPPQQETGEPGGHAGPTRQP
>NC_015656.1|WP_131772013.1|304624_305329_-|hypothetical-protein
MGVLLALASGSCGGSRQPAGNTTPEQPVVPVASAAARTNLHAGDYVLTQGPETTGFNASTSLDNRGALSVAAMTGFAACVGRSGADPKIEPLDSAKGPYFATNDNLVFMGSVAAVYPAEVITEAVRIAADPSFPSCVGDLLKRGYTEAADLPEGSTFTILSTTKRTPPAGVTALTRVKASMTLDGPAVPMTFDVMFVFAGQVQSSFLVGRVFDAPDQAVVNRIAKQIVRKTANQ
>NC_015656.1|WP_043604398.1|305618_306245_+|UdgX-family-uracil-DNA-binding-protein
MPFVPPDADLAGLAAAAASCRGCELADLPDTRTVFGEGNPRARLVLVGEQPGDVEDRRGRPFVGPAGKLLDRALADAGIDRAEAYVTNAVKHFRYRRNGGPRRIHQTPDARQVTACRPWLAAELNRIRPRLVVLLGATAGQALLGPSFRVTKMRGRLLPGPPGSDAQLIATLHPSAVLRVEPTTRDEVYAGFVHDLELAERTLAGMTG
>NC_015656.1|WP_131772015.1|306368_307247_-|L,D-transpeptidase
MPAGSAPTGGTPTSTSTSVSAAAAAGNTPPPRRLSPRRAGIPSLVLAGLITFTGCGGGSADSPTGTQPTAPTSTAVPQAAHSELAAAASVNQDGTSTIVTAVVPKVDIYKSPIAASVVSQLSNPNEAGAPRVFLVVAKLPGWWQVLLPVQPAGTTGWVKDAQVKASQTSYRVEVARKEHRLRVYDKQQVVVDEPTAVGTGDTPTPGGKFYLTELLQPRNPAGAYGPYAFGLSGFSTTLDSFEGRAPVIGIHGTNQPNLLGQDVSHGCIRVSNETITRLARLLPLGTPVEIVA
>NC_015656.1|WP_131773795.1|307318_307879_-|hypothetical-protein
MPAQSGLPLSLPANLPANLPANLPANLPADITQLSPDVLHNLLSLVPGLPVDIQGLLDLSKVGNLLAQPLALLHSCGPDGGKWQLKNTSDKPFGFGWYDTKGKGGTGEIPPGGLITLVTHVLDAVLAIPFDLLSGSLLKAIPAIGVANCPGADNGGGGADQQQDVDTVPVSTPANAVVTDRVYYTG
>NC_015656.1|WP_131772017.1|308298_309102_-|pyridoxamine-5'-phosphate-oxidase
MDGVSTRPNHARPPVPDPAAQRRCYSAGRLHESDLAPTWVAQFARWYEQASAVAAEPGSALPEPNAMVFATADARGRPSARTVLLKGFDERGFTLFTNLGSRKAREATANPYGSLVFPWHALQRQIVAVGGLEEVSRAETAAYFRSRPRGSQLGAWASRQSEVIGSRDWLDRRWAELDARWPAPEPVPVPAFWGGIRLVPETVEFWQGGSDRLHDRLRYRRIDADDTPADTSADEVRAGEPRSGERGTGGHGQSHADGRWIVERLSP
>NC_015656.1|WP_043604402.1|309449_310544_+|citrate-synthase-2
MSEKTSDFKPGLEGVIAFETEIAEPDREGSALRYRGVDIEDLVGKVDYGHVWGLLVDSSFEPGLPPAEPFPLPVHSGDIRVDVQSALAMLAPHWGFGQLIDISDAQARDDLARASVVALSFVAQAARGLGQPAVPQKDVDRARTITERFMIRWRGEPDPKHVQAVDAYWVSAAEHGMNASTFTARVVASTGADAAASLSSAVGALSGPLHGGAPSRVLAMLDEVEATGDPAGYVRRALDRKERLMGFGHRVYRAEDPRARVLRRTARDLGSNRYEAAEALEAAAIEELTNRYPDRPLRTNVEFWSAVVLDYAGVPAHMFTSMFTCARTAGWSAHILEQKRTGRLIRPSARYVGPAPRPLGDVHA
>NC_015656.1|WP_013871819.1|310536_311655_+|phosphoserine-transaminase
MPDQIVIPEHLRPVDGRFGCGPSKVRPEAVARLAATGTSLLGTSHRQKPVRALVGRVRAGLAELFSLPDGYEVVLGLGGATAFWDAAAFNLVRERSQHLVFGEFGGKFADTTKGAPFLAEPSVVSSAPGSHPEWAPEPGVDVYATPHNETSMGVAKPVRRPIGADAGALHLVDATSGAGGLPVDISQADAYYFAPQKNFASDGGLWVALLSPAALERLAEIAASDRWIPPFLDLTTARGNSAKDQTYNTPAVATLFLFADQVEWMLAGGGLDWCVRRTAESSSILYTWAEKTSYATPFVADPAQRSQVVVTIDFEGVDAAAVARTLRANGIVDVEPYRKLGRNQLRVACFPAVEPSDIQALTGAIDHVVERL
>NC_015656.1|WP_013871820.1|311846_313214_-|citrate-synthase
MTEQVSTLTVTDNRTGRTYEIPIENGAIRANTLRSIKLDESDFGLLTYDPAFTNTASCRSAITFIDGDAGILRYRGFPITELADKSSFLEVAYLLLAGELPTASELAVWESEITHHTLVHESIKKFIDGFYHDAHPMGILLSSVGALSTFYPDAKEISDPGLRRLQIVRLIAKITTLAAFSYRHSIGLPYVYPDNDLSYAGNFLNMMWKATELKYEPDPILEHALDVLFILHADHEQNCSTNAMRAVGSSQADPFSAAAAAISALYGPLHGGANEQVLRMLTEIGSVENIPAFIEQVKSGKKKLMGFGHRVYKNYDPRARVIRQIADEVFKVTGTNPLLDLALELERVALEDEYFIKRKLYPNVDFYTGIIYQAMGFPVEMFPVLFAVGRMPGWLAQWEEGLLDPEQKIARPRQLYVGHEERPYTPIEDRSPDFVGASDSIAALAAQAAPARPRR
>NC_015656.1|WP_013871821.1|313628_314633_+|aldo/keto-reductase
MIHAHLGRTGVRVSRLCLGVMNVGPSVGTDLSGAVMDRALDAGITFFDTFLDTANAHGRPTRTTGHTDAGAAEYAVGDWLSRNRGRRDQIVLATGLHGPASPGPGRPAGDGKLSGPEIRRRCEESLRRLRTDHIDLLQLSSPARDTPWEEIWQATDMLAAQGKIVYVGSSGLAGWEIAAGNEAAMRRRSLGLVSNLCDYSVLERAAETEVLPVCQSYGVGVIGRSPLLDALLDGVSAYAPAGVPEQRQVKRRLERYRPRFEAFVALCESFGERPASVALAWLLAQPELTAATIRPHGVDELTAALRALEIVLGERELDTLDRIAPGPAVAVADR

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_015656_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015656_2

610144-610226

Orphan

Consensus_repeat	Method
GAGTATCCGCACCCGGCGCGGGG	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NC_015656_2

>merge|NC_015656|2|610144-610226|CRISPRCasFinder
GAGTATCCGCACCCGGCGCGGGGGGGTGGACAGCCGGTCTACGAGACTCCGGACGTGCTGGAGTATCCGCACCCGGCGCGGGC

>NC_015656|2|2|610144-610226|CRISPRCasFinder
GAGTATCCGCACCCGGCGCGGGG	GGGTGGACAGCCGGTCTACGAGACTCCGGACGTGCTG
GAGTATCCGCACCCGGCGCGGGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015656.1\|WP_050803300.1\|614779_614989_-\|toll/interleukin-1-receptor-domain-containing-protein	unknown	unknown	gnl\|CDD\|379328
NC_015656.1\|WP_013872051.1\|605553_605976_-\|DUF2795-domain-containing-protein	unknown	unknown	unknown
NC_015656.1\|WP_013872062.1\|625590_626001_+\|arsenate-reductase-ArsC	unknown	unknown	gnl\|CDD\|319973
NC_015656.1\|WP_013872061.1\|624735_625566_+\|aquaporin-family-protein	unknown	unknown	gnl\|CDD\|223653
NC_015656.1\|WP_013872043.1\|599498_599714_-\|FXSXX-COOH-protein	unknown	unknown	gnl\|CDD\|275092
NC_015656.1\|WP_083828123.1\|617777_621632_+\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|274362
NC_015656.1\|WP_131796150.1\|623654_624074_-\|helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|197713
NC_015656.1\|WP_013872044.1\|599821_600148_-\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|380358
NC_015656.1\|WP_013872048.1\|601734_603513_-\|NAD-binding-protein	unknown	unknown	gnl\|CDD\|366883
NC_015656.1\|WP_043604566.1\|603720_604662_-\|dihydroorotate-oxidase	unknown	unknown	gnl\|CDD\|240092
NC_015656.1\|WP_013872058.1\|622040_623558_+\|substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|270371
NC_015656.1\|WP_013872050.1\|605107_605350_+\|acyl-carrier-protein	unknown	unknown	unknown
NC_015656.1\|WP_013872045.1\|600261_601062_+\|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl\|CDD\|376556
NC_015656.1\|WP_013872052.1\|606833_607637_+\|DUF1918-domain-containing-protein	unknown	unknown	gnl\|CDD\|341390
NC_015656.1\|WP_013872046.1\|601046_601550_-\|hypothetical-protein	unknown	unknown	unknown
NC_015656.1\|WP_050803301.1\|626188_627337_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225107
NC_015656.1\|WP_043604572.1\|624181_624736_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319917
NC_015656.1\|WP_013872053.1\|607736_608387_+\|phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|224837
NC_015656.1\|WP_131772070.1\|615245_617489_-\|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272
NC_015656.1\|WP_013872055.1\|611325_613521_+\|protein-kinase	unknown	unknown	gnl\|CDD\|238121

Protein	Function_ID	Function_description	E-value
NC_015656.1\|WP_050803300.1\|614779_614989_-\|toll/interleukin-1-receptor-domain-containing-protein	gnl\|CDD\|379328	pfam13676, TIR_2, TIR domain. This is a family of bacterial Toll-like receptors.	2.53093e-20
NC_015656.1\|WP_013872052.1\|606833_607637_+\|DUF1918-domain-containing-protein	gnl\|CDD\|341390	cd04622, CBS_pair_HRP1_like, CBS pair domain found in Hypoxic Response Protein 1 (HRP1) -like proteinds. Mycobacterium tuberculosis adapts to cellular stresses by upregulation of the dormancy survival regulon. Hypoxic response protein 1 (HRP1) is encoded by one of the most strongly upregulated genes in the dormancy survival regulon. HRP1 is a 'CBS-domain-only protein; however unlike other CBS containing proteins it does not appear to bind AMP. The biological function of the protein remains unclear, but is thought to contribute to the modulation of the host immune response. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).	9.62164e-30
NC_015656.1\|WP_050803301.1\|626188_627337_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	8.38122e-14
NC_015656.1\|WP_013872061.1\|624735_625566_+\|aquaporin-family-protein	gnl\|CDD\|223653	COG0580, GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism].	2.14011e-35
NC_015656.1\|WP_013872043.1\|599498_599714_-\|FXSXX-COOH-protein	gnl\|CDD\|275092	TIGR04268, FxSxx-COOH, FXSXX-COOH protein. Members of this family are very short (~60 residue) polypeptides, among which the fifth and third to last residues are nearly always Phe and Ser, respectively. Because members occur in a conserved context with a putative peptide-modifying radical SAM/SPASM domain protein, we suggest that members of this family may be the modification target. The gene symbol fxsA reflects both the FXA motif and the proposed role as a ribosomal natural product.	1.26761e-07
NC_015656.1\|WP_013872053.1\|607736_608387_+\|phosphoribosyltransferase	gnl\|CDD\|224837	COG1926, COG1926, Predicted phosphoribosyltransferases [General function prediction only].	2.65438e-81
NC_015656.1\|WP_013872062.1\|625590_626001_+\|arsenate-reductase-ArsC	gnl\|CDD\|319973	cd16345, LMWP_ArsC, Arsenate reductase of the LMWP family. Arsenate reductase plays an important role in the reduction of intracellular arsenate to arsenite, an important step in arsenic detoxification. The reduction involves three different thiolate nucleophiles. In arsenate reductases of the LMWP family, reduction can be coupled with thioredoxin (Trx)/thioredoxin reductase (TrxR) or glutathione (GSH)/glutaredoxin (Grx).	2.79059e-49
NC_015656.1\|WP_013872044.1\|599821_600148_-\|cupin-domain-containing-protein	gnl\|CDD\|380358	cd02230, cupin_HP0902-like, Helicobacter pylori HP0902 and related proteins, cupin domain. This family includes prokaryotic and archaeal proteins homologous to HP0902, a functionally uncharacterized protein from Helicobacter pylori and Spy1581, a protein of unknown function from Streptococcus pyogenes. These proteins demonstrate all-beta cupin folds that cannot bind metal ions due to the absence of a metal-binding histidine that is conserved in many metallo-cupins. HP0902 is able to bind bacterial endotoxin lipopolysaccharides (LPS) through its surface-exposed loops, where metal-binding sites are usually found in other metallo-cupins, and thus may have a putative role in H. pylori pathogenicity.	7.56885e-06
NC_015656.1\|WP_013872048.1\|601734_603513_-\|NAD-binding-protein	gnl\|CDD\|366883	pfam02026, RyR, RyR domain. This domain is called RyR for Ryanodine receptor. The domain is found in four copies in the ryanodine receptor. The function of this domain is unknown.	3.22094e-12
NC_015656.1\|WP_043604566.1\|603720_604662_-\|dihydroorotate-oxidase	gnl\|CDD\|240092	cd04741, DHOD_1A_like, Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires FMN as co-factor. DHOD divides into class 1 and class 2 based on their amino acid sequences and cellular location. Members of class 1 are cytosolic enzymes and multimers while class 2 enzymes are membrane associated and monomeric. The class 1 enzymes can be further divided into subtypes 1A and 1B which are homodimers and heterotetrameric proteins, respectively.	3.78879e-84
NC_015656.1\|WP_013872058.1\|622040_623558_+\|substrate-binding-domain-containing-protein	gnl\|CDD\|270371	cd13653, PBP2_phosphate_like_1, Substrate binding domain of putative ABC-type phosphate transporter, a member of the type 2 periplasmic binding fold superfamily. This subfamily contains uncharacterized phosphate binding domains found in PstS proteins that serve as initial receptors in the ABC transport of phosphate in eubacteria and archaea. After binding the ligand, PstS interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The PstS proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	6.73335e-49
NC_015656.1\|WP_131796150.1\|623654_624074_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197713	smart00418, HTH_ARSR, helix_turn_helix, Arsenical Resistance Operon Repressor.	2.99004e-20
NC_015656.1\|WP_013872045.1\|600261_601062_+\|N-acetylmuramoyl-L-alanine-amidase	gnl\|CDD\|376556	pfam01510, Amidase_2, N-acetylmuramoyl-L-alanine amidase. This family includes zinc amidases that have N-acetylmuramoyl-L-alanine amidase activity EC:3.5.1.28. This enzyme domain cleaves the amide bond between N-acetylmuramoyl and L-amino acids in bacterial cell walls (preferentially: D-lactyl-L-Ala). The structure is known for the bacteriophage T7 structure and shows that two of the conserved histidines are zinc binding.	9.52339e-06
NC_015656.1\|WP_043604572.1\|624181_624736_+\|VOC-family-protein	gnl\|CDD\|319917	cd07254, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	6.95281e-45
NC_015656.1\|WP_083828123.1\|617777_621632_+\|HAMP-domain-containing-protein	gnl\|CDD\|274362	TIGR02956, sensor_protein_TorS, TMAO reductase sytem sensor TorS. This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems].	8.89782e-69
NC_015656.1\|WP_131772070.1\|615245_617489_-\|SpoIIE-family-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	8.98009e-37
NC_015656.1\|WP_013872055.1\|611325_613521_+\|protein-kinase	gnl\|CDD\|238121	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.	4.02661e-88

>NC_015656.1|WP_013872053.1|607736_608387_+|phosphoribosyltransferase
MHPLFADRPAAGRALAGQLAVYAGRDDVVVLALPRGGVPVAFEVARRLGAGLDVFPVRKLGAPGHAELAMGALAGGGTLVRNDQVIYSLGIGEETIAEVVAAERRELARREDAYRLGRDALDVTGRVVLLIDDGMATGATMYAAVDAVRQRGPAQVVVAVPVASEQACRQMRFVADGVLCLRTPSTFFSVGQYYADFSQTTDDEVRELLRRAVTAG
>NC_015656.1|WP_013872052.1|606833_607637_+|DUF1918-domain-containing-protein
MANVLSVTSVPPVTVRRYRTIGEAAHEMDLHGVGALLVTDDRDHLVGIVTDRDIVLRGVARGVPMETSVDRLMTTEVFTLPVDAELDRAYEVFRDHALRRLPVLDGDRIVGVLSIDDLLIRDARRIEDVVRPLAREVIARHRRTPVGTGGAVRAGDGAVRADNGGTYAGSGAGSGGTYADSGVIASRRLVRAHPGDTLVIHGRTLGRPERSGEILEVRSPSGDPPFLVSWSDSDHVSFTYPGPDAEVRPRAEAATAATGERAGNGSR
>NC_015656.1|WP_013872051.1|605553_605976_-|DUF2795-domain-containing-protein
MSMQRGSTKHGPAKDDNLAQEVDGIVRARRDTRTEEWRSAEPPGEDQPQVAVIPERPASEAAANTDPTAAVEARSELARWFDRHDFPARAAQLTYVLRGRNAPEQLVERLAARPKREQYDSFGHLWRALHGGEDVETVRF
>NC_015656.1|WP_013872050.1|605107_605350_+|acyl-carrier-protein
MATGGTGFSDVVHDLISVQYHALKGGREYEQYIRDANEEGQPEIADFFRTVLEQDAERAVACHRYLSRLSGHAPAGSIVR
>NC_015656.1|WP_043604566.1|603720_604662_-|dihydroorotate-oxidase
MAALCGVELEHPLMNAAGTCKSLDEVSALARSAVSAVVVGSITLRARTGNGGNVYYPGDFFSLNALGLPNPGLAYYREHLPAMISMAHAAGKPLVVSIAGFSEAEYAIAAHDVALAGADIIELNLACPNVWDDGRQKRIACFDNDRTEAICAQVGQALAAAASTATGGGEDRQPPPFGIKISPFSDPAGLAALADLVARLSGTPRGPRFVCAVNTFPNAFALDEANRPVIDVELAGLAGAALRPVALGQVRQLRRLLPETVELIGVGGVSRGRDIADFLRAGATTVQAATAFWNRNGDAGVFGDILTDYVDLF
>NC_015656.1|WP_013872048.1|601734_603513_-|NAD-binding-protein
MTGIPDERAGGGRALWLMFAVLFLVAAFLGAWGLTQLDQPDSRCPPPDTRACRYPAADIAYFDAQLFLLASEPLQDGGPFPLPLEVARFLAPFATAYGVTASVWNILVDRRHRRAARRAQEHAVVVGDDPFALTITTALRAAGTTVIRVTGDADQHAQGLVVVGDAWKPATLRAAGVPRATTVYACLADNAANAAVVAAVAALTGEEGDHPEPLACYARISDGELALALKARRLGLSAGSGFRLDFFTPEEIAARKLATHILEPHLGTGDPLPSVAVVGLGPFGRALIVALARLWRVRSGAPPLPLVLVDTHASAQLAELRTRYPPVAAHCAPRVRDEPATTVDLGTVLPEPPSAGASGDAGTLGIRHLVLCDQNEDTVLPRALNTTRNTVDVGQIVTVCTGQRTALGDLLNPRLLDSAPGEVRIFAITDEAAEPDELRNDTLTVLARAIHEQYLIDEQAKGRTIGSAEPMDLWDDLRDDLRAANYRQAEDIGVKLGKISAVVVPMTDPPTDFSFTPAEIDLLARHEHERWCAERRGQGWTFAPVRDDSRRRHNLLVDWLDLPDDQRAKAIATVRHLPALLADHGLQILRLG
>NC_015656.1|WP_013872046.1|601046_601550_-|hypothetical-protein
MSVIGWRQWAVDGAGRLRPAWTPWSPFPTDLLLWYPDGLTRALCLRGVRDDFGGQPSSASLAASLTPHPRMPGEACACGLYGWLSARELAAAATPRWTSRPIVVGAARLGGRLVVSERGYRAQLGYPVAVVDPDGVVSSAYSVARYRTWDALVTEWDQSADWDQPVK
>NC_015656.1|WP_013872045.1|600261_601062_+|N-acetylmuramoyl-L-alanine-amidase
MAHIVQGFQYRPVRNTAGDTIRPIGLVLHVAQGNGSQFNWFNDPRSQVSSNLWAGKAGQREQYVPSDVRAWAQLAGNGTYNSIETEGFDTEALTPEQIESVAVAYADGVHAFGWALAVTDTPGQSGLITHGAGNLAWGNHPGCPGAIRAGQRQQIVVRAAQIVGGSASPTQPKVVALQHAVHVAADGVWGPATDAALAAVRANQHTRAEQAAVGATVDGAWGPRSQAAYVATVRTIQSILEVGVDGVWGPVTDRAFVAARNSYFTG
>NC_015656.1|WP_013872044.1|599821_600148_-|cupin-domain-containing-protein
MHVSVTAGTALPHDVEATLVRQGLRPYRWSAGPGEIFDEHTHAQHKVLFCVNGKIIFRVGGTDWPMRPGDRLDLPANTRHEAIAGPAGATCVEAFLPATGPQPGDVSV
>NC_015656.1|WP_013872043.1|599498_599714_-|FXSXX-COOH-protein
MSDALHAEPGPVDPPRTDLSRLTTLDDSALRHALRRVLRETTDPHTAIAGFNSFSSDPTRRHSNRGPLPHL
>NC_015656.1|WP_013872055.1|611325_613521_+|protein-kinase
MTVDRARVAAALPGYELGDELGAGTFGVVLAGWHRSLQRDVAIKMMLGKHGRAAAGFATEARVLAALDHPHVVRVYDYVETGELRLLVMEMLAGGTLTCCHQAGMLQEGACAVGLAIAAALACAHSRGVLHRDIKPDNILFDTTGLLKVVDFGLAKQVGGLPVTASAVAGTPLYMAPEQIDGGRLGPATDLYALGVLLYLLLTGVTPFAPAPSILRQRLEQVPPPPPDVPVRVADAIMWALANDPVARPPSAQAFALYLARAAAEAYGAGWLARSGLVLHLDDDVRAAAERPSVSAPPPLPPIAKSNILSPKSDTAPSPSAGDAPADSLLSQGIASATQVGDRPTGRVRRVRPHHRSAVPPAHRRPGGAPRHRGASRCRIAVIAFLLAGAVALVAATRSGDPSDISIRPLSPPLTGHTHWVLSVLFSPNQRVLASSSRDGTVRLWDVTDRSQPRLLGRPLTGPTDGVTSVAFSPDGHTLAGSSWDRTIWLWDVTDPSAPRLSAGPVSGHRDAVTSVAFSPDGKVLASGSNDGTVRLWDVADRSGPRPLGKPLISHADAVTSVVFSPDGRTLASASYDKTVRLWDLTDRSRPRLFGAPLVGHTMFVFSVAFSPDGHVLASGSYDGTIRLWDVTNRSDPHPAGDHLRVSSTTVRSVAFSPDGRTLASGSFDGTVRLWNVTDLSSPYPRNDSLTVHGDWVMSVVFSADGRTLATGSNDKTVRLWELRQPASAGS
>NC_015656.1|WP_050803300.1|614779_614989_-|toll/interleukin-1-receptor-domain-containing-protein
MVDERPAGLPVIFISYTQVDRAWAEWIAWQLTETGYDVHLQAWHLMPGTNWAAWMQRMTDEADHTLVVL
>NC_015656.1|WP_131772070.1|615245_617489_-|SpoIIE-family-protein-phosphatase
MIVRQQGELEAVRAQAATEALVDLAIGVLTERLRCSPGEAARQLTHLAARSGMPLAELAADVVGQPAGDALVRGSAQPPRHQPAQLADAPAPRAVDGSRIAVATLEEALAPLGAVAVALWMTEPDGALELAGEAGLSALEASRWQRLPPQMDCPAQRVVQDGCPRWWPAAHHLPRPLPLVGPWRGARAVLPLTDAGALLGAMEICWPQPLEEFAPALRHQLLTLAGVCASSLGVQGERTWGRHGSWLPALLDALLCSALVAHAVRDHDGRIVDFQIDHVSDGFVDPAGRGPRDLVGRRLSHVHPLMTVPDGLFEHAVDVLRTGQPYQADSLPVHVIVGDRIVATEMDVRIGRLFDGIALTWRRADDSNGLTTILQHAQRLGELGGWQQDVLTGDVRWTDHTFTLFRLMPDAPEAPISLQGLDAHVHADDLDAVRRFRDVLFNQVRPAATTFRLLRADGAIRQIRAFAEPVTDAAGTLVAVRGTYQDLSTLYHTQVALAATRGQLADTEQRADDQQRLAIQLQRAITPFSADPVETAGFDIAVRYRPANQDHLVGGDWYDAVVLPSGEVLLTVGDIAGHGIRAVTGMVTLRNSLRGLAMTGAGPAQLLRWLNDVAYHLTDDVTGTAVCGLYDPATRVLRWACAGHLPPVLVRDGDAGTLPLPAGVLLGADPHSAYEETATALRPDDGVLLFTDGLIERRGSALDEALDTLVLVAGRPIADLQRYADHLLRHTTPDTDDDTCLIAVHLR
>NC_015656.1|WP_083828123.1|617777_621632_+|HAMP-domain-containing-protein
MRVRWLVGICPRRLRATIPRPFEKTLGHQETGSSALSVSPWFANRPTLYRGARGPAGCSGSAADERGVPVGEATKSERVKSEGATTGGRDEPALRQLLAGLTAVRGGDFRVRLPYGEDPLMNEIADVFNGMTDQLSAIASEVAGAAREVGIEGRLGRHLRVPDAPGAWRELIESTNMAVGSLGGQVRDISQVAAAVARGDLSRKITVEAHGEVLELKNTINTMVDQLSSFAGEVTRVAREVGTEGRLGGQAFPGVGGTWRDLTDSVNFMAGNLTVQVRSISQVAAAVARGDLSQKITVDARGEVLELKNTINTMVDQLSSFAGEVTRVAREVGTEGRLGGQADVKGVSGTWKDLTESVNVMAANLTVQVRSIAEVTTSVAKGDLTQKIRVDARGEVLELKETINTMVDRLSSFADEVIRVAGEVGTQGNLGGQAVARGVSGTWRDLTDNVNSMASNLTSQVRNIAQVTTAVARGDLSKKIDVDARGEILELKTTINTMVDQLSSFAAEVTRVAREVGTEGMLGGQAEVEGVSGTWKRLTENVNELAGNLTRQVRAIAAVTSAVAAGDLTGSVSVEARGEVAELKDNINAMVRSLYETTRANQEQDWLKTNLARISGLMQKHRDLNTVTELVMDELTPLVGTQYGTFFLAGSGAGTPAPALRLIASFGYQAHPDVPREFDLGQSLVGQVARTKKSIFIDRTPVHYVKISSSLGHAEPVNLIVLPVLFEDHVLGVIELASFTPFTQVHRDFLDRLMEIIGVNINIIVANSRTDALLAESQRLAAELRARSEELQSRQDELQRSNAELAEKAALLARQNHDIEIKNFEIEQTRQEIEERARQLALSSRYKSEFLANMSHELRTPLNSLLILARLLAQNPANNLSPKEVEYANVIHSAGSDLLQLINDILDLSKVEAGKIDIHLERFALSALLDDVQGIFCPIIEEKGLRFTVEVAPDVPDALVSDQQRLLQVLRNLLSNAVKFTQLGGVELRIRVVSDRVLDDERRPAVAFAVIDTGIGIAEENLDRLFGAFQQGDGSTSRRFGGTGLGLSIAREVAALLGGVIRAQSEFGQGSTFTLYLPLSSPGAIGEQAHGATRPAVSGPPTPAALPLPPGSSGSSGSSGLSGPQVSAAAPVSAPTPGDNGIPAHATTDDVLRGRRILVIDDDVRNVFAITSILELYGLTVIHAPDGRMGIDILLATDGIELVLVDVMMPEMDGYATMTAIREMPRFGALPIIAVTAKAMPGDRQKCLAAGADDYVTKPVDTDKLLACIRQRLTRQKPDDRNTR
>NC_015656.1|WP_013872058.1|622040_623558_+|substrate-binding-domain-containing-protein
MGWLSTENIVAVLTAVLGIVASFAVVWYERRVPHRRRIGYRVQMDTPIGSDNRGGQSQVDTRLGLFNDLPDMSDGTLVLLRIENDGAEGITDTDYTSNGLTVVFTERTVRGVAVTQSDAEHLMDHFAPPGAMRHSGSMIHLPRVPLNRGQHYKLLVLLTGGRVGLGVRVTGGIRDGKVEPNRSTTVDDTPPLFSGPARWITILLTLCVTALAVIVVRRDVPPPIGCATGKLTIIGSTAFAPVVREIAEKYESECPETRITVSPRGSNEGIQELAEAATETADGPPAVISVYDGSKPAGYPQMMGERIGISAFALVVNDSVSTVDLTVDQIRMIYRGDILNWSQVGGPDLPVLLVSRDANSGTRDLFRRRILDGLGEPALTSLDCEHRNSPQDRVVRCELDSTERVLRTVAKLPGAIGYSELQAAVAAGGLHALRINGQTPSIEAIGDDSYPFTEIEYAYTYGQPPTGSLTASFLNYLTRGGGQDVMKAHGHLPCYSPEGFRRCQQ
>NC_015656.1|WP_131796150.1|623654_624074_-|helix-turn-helix-transcriptional-regulator
MATAPLPTPLPARAAPTGPGTRADSDASGLAGLPVVCCTPLTRAPLPAEEAERLVTVLRAIAVPARLRLLSMIYARENGEACVCELTEPLGLSQPTVSHHLKVLVDAGLITRDKRGVWAYYRAVPDALAALATVFAPPR
>NC_015656.1|WP_043604572.1|624181_624736_+|VOC-family-protein
MPRVQLALNVSDVDAAVDFYTKLFGAGPAKRRPGYANFAIDVPPLKLVLIENPRARGAGVAGALNHLGVEVTTSEEVTAATTRLAGAGLDTATEENSTCCYAVQDKVWVDDPDGAPWEIYTVLADVPDRTDAATGVGPALRTVEPGGGPGSACACGPGGDCAPTADTGTAVPLATAGRAGHAGC
>NC_015656.1|WP_013872061.1|624735_625566_+|aquaporin-family-protein
MAQVRPGPPPLARRLVAEAIGSMLLAALVIGSGIAATQLSPGQTGLQLVENAAATAAGLFAIILMVGPVSGGHFNPVVSGVDAAFGGLPWRDAAAYVPAQVTGCVGGAVLANLMFEEPAVSISTRHRASGAHLLAEVVATAGLILLIFALTRSGRGDRAPAAVGAYIGAAYWFTSSTSFANPAISVGRMLSNTFAGIAPTSVPAFVGMQAIGGMIGYGLVRLLYPPPPTAPDHATRVLSPRNQPTTASRDVASDATTSGGRTSNSTAPGLARGISL
>NC_015656.1|WP_013872062.1|625590_626001_+|arsenate-reductase-ArsC
MSGKPSVLFVCVHNAGRSQMAAGWLTWLSGGAVDVRSAGSLPAERVNPVAVAAMAEMGIDLGAQTPKVFTSEAVEASDVVVTMGCGDVCPVFPGKRYEDWKLDDPAGQGIDAVRLIRDEIRARVEKLLQDLLPPVS
>NC_015656.1|WP_050803301.1|626188_627337_+|helix-turn-helix-transcriptional-regulator
MAVDRELLLDRVGELAERVRAVLEGPAVEDAGESSELAQALAAAGAEIRAVLCARPTPDARTAGELCLGLVELRRLRGELREYAVSVRFAAVARIHRGLAKLRACETVAELLPAAAAELGACCDFDRAVISRRRGSTWRAEAVWLAPGLDPSVSRATEVYLRGTWIPLGPGVLETELIRRRTAEVIAADDPRTNKELMAVSDSVGYVASPVMPAGRVIGFLQADCYGSRRELTTLDRDNLWTFAQGFGLLFERTVLLERLAQQRAQAREAFELAERQLRQLAEDEILLARSDRELGAVASRAADLFRPVTAADDPVASLLTARERRIVELMVTGARNSEIADRLVLSEDTVKSHVRSVLRKLRSANRAEAVSRYLKIAMSQS

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_015656_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015656_3

851605-851688

Orphan

Consensus_repeat	Method
CCCGCCTCCCCGGGGCGCTGGTGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015656_3

>merge|NC_015656|3|851605-851688|CRISPRCasFinder
CCCGCCTCCCCGGGGCGCTGGTGGGTGTCGCTGGGCGGCACCGCGCCGACAGGCGGTCGGCCCGCGTCCCCGGGGCGCTGGTGG

>NC_015656|3|3|851605-851688|CRISPRCasFinder
CCCGCCTCCCCGGGGCGCTGGTGG	GTGTCGCTGGGCGGCACCGCGCCGACAGGCGGTCGG
CCCGCGTCCCCGGGGCGCTGGTGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_015656.1\|WP_013872235.1\|861898_862858_+\|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA	unknown	unknown	gnl\|CDD\|234708
NC_015656.1\|WP_043604699.1\|835460_835871_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|340413
NC_015656.1\|WP_131772115.1\|855858_857421_-\|phospholipid-carrier-dependent-glycosyltransferase	unknown	unknown	gnl\|CDD\|374423
NC_015656.1\|WP_193353101.1\|843369_844062_+\|response-regulator	unknown	unknown	gnl\|CDD\|381147
NC_015656.1\|WP_013872233.1\|859563_860667_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380561
NC_015656.1\|WP_013872228.1\|852775_854050_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|275035
NC_015656.1\|WP_083828421.1\|836081_837521_-\|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272
NC_015656.1\|WP_165440835.1\|854411_855926_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224720
NC_015656.1\|WP_043604710.1\|858757_859228_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|99750
NC_015656.1\|WP_131772113.1\|845681_846497_-\|DUF305-domain-containing-protein	unknown	unknown	gnl\|CDD\|367619
NC_015656.1\|WP_131772112.1\|838997_842978_+\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|236848
NC_015656.1\|WP_050803318.1\|857571_858480_+\|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase	unknown	unknown	gnl\|CDD\|223390
NC_015656.1\|WP_013872217.1\|832077_833457_-\|cystathionine-beta-synthase	unknown	unknown	gnl\|CDD\|273464
NC_015656.1\|WP_131772111.1\|833760_835383_-\|alanine-racemase	unknown	unknown	gnl\|CDD\|143510
NC_015656.1\|WP_013872234.1\|860960_861785_+\|TatD-family-hydrolase	unknown	unknown	gnl\|CDD\|238635
NC_015656.1\|WP_013872236.1\|863193_863919_-\|alkaline-shock-response-membrane-anchor-protein-AmaP	unknown	unknown	gnl\|CDD\|380217
NC_015656.1\|WP_013872216.1\|830747_832061_-\|cystathionine-gamma-synthase	unknown	unknown	gnl\|CDD\|236104
NC_015656.1\|WP_013872226.1\|851758_851962_-\|hypothetical-protein	unknown	unknown	unknown
NC_015656.1\|WP_013872224.1\|848312_850100_-\|glycoside-hydrolase-family-15-protein	unknown	unknown	gnl\|CDD\|225922
NC_015656.1\|WP_043602884.1\|850746_851292_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_015656.1\|WP_013872235.1\|861898_862858_+\|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA	gnl\|CDD\|234708	PRK00274, ksgA, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase RsmA.	4.04447e-112
NC_015656.1\|WP_043604699.1\|835460_835871_-\|ATP-binding-protein	gnl\|CDD\|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	1.47517e-13
NC_015656.1\|WP_193353101.1\|843369_844062_+\|response-regulator	gnl\|CDD\|381147	cd19920, REC_PA4781-like, phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains. Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	2.06475e-34
NC_015656.1\|WP_165440835.1\|854411_855926_+\|hypothetical-protein	gnl\|CDD\|224720	COG1807, ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane].	5.17231e-05
NC_015656.1\|WP_013872228.1\|852775_854050_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|275035	TIGR04182, glyco_TIGR04182, glycosyltransferase, TIGR04182 family. Members of this family are glycosyltransferases restricted to the archaea. All but two members are from species with the PGF-CTERM/archaeosortase A system, a proposed maturation system for exported, glycosylated proteins as are found often in S-layers.	1.56152e-39
NC_015656.1\|WP_131772113.1\|845681_846497_-\|DUF305-domain-containing-protein	gnl\|CDD\|367619	pfam03713, DUF305, Domain of unknown function (DUF305). Domain found in small family of bacterial secreted proteins with no known function. Also found in Paramecium bursaria chlorella virus 1. This domain is short and found in one or two copies. The domain has a conserved HH motif that may be functionally important. This domain belongs to the ferritin superfamily. It contains two sequence similar repeats each of which is composed of two alpha helices.	1.27252e-41
NC_015656.1\|WP_043604710.1\|858757_859228_-\|hypothetical-protein	gnl\|CDD\|99750	cd06259, YdcF-like, YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been idenitified. The family also includes Escherichia coli sanA and Salmonella typhimurium sfiX, which are involved in vancomycin resistance; sfiX may also be involved in murein synthesis.	6.98746e-08
NC_015656.1\|WP_013872224.1\|848312_850100_-\|glycoside-hydrolase-family-15-protein	gnl\|CDD\|225922	COG3387, SGA1, Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism].	2.75207e-112
NC_015656.1\|WP_131772112.1\|838997_842978_+\|HAMP-domain-containing-protein	gnl\|CDD\|236848	PRK11107, PRK11107, hybrid sensory histidine kinase BarA; Provisional.	8.50784e-85
NC_015656.1\|WP_050803318.1\|857571_858480_+\|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase	gnl\|CDD\|223390	COG0313, COG0313, Predicted methyltransferases [General function prediction only].	4.54155e-105
NC_015656.1\|WP_013872217.1\|832077_833457_-\|cystathionine-beta-synthase	gnl\|CDD\|273464	TIGR01137, Cystathionine_beta-synthase, cystathionine beta-synthase. Members of this family closely resemble cysteine synthase but contain an additional C-terminal CBS domain. The function of any bacterial member included in this family is proposed but not proven. [Amino acid biosynthesis, Serine family].	0
NC_015656.1\|WP_131772111.1\|833760_835383_-\|alanine-racemase	gnl\|CDD\|143510	cd06843, PLPDE_III_PvsE_like, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE. This subfamily is composed of PvsE from Vibrio parahaemolyticus and similar proteins. PvsE is a vibrioferrin biosynthesis protein which is homologous to eukaryotic ornithine decarboxylase (ODC) and diaminopimelate decarboxylase (DapDC). ODC and DapDC are fold type III PLP-dependent enzymes that contain an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain, similar to bacterial alanine racemases. It has been suggested that PvsE may be involved in the biosynthesis of the polycarboxylate siderophore vibrioferrin. It may catalyze the decarboxylation of serine to yield ethanolamine. PvsE may require homodimer formation and the presence of the PLP cofactor for activity.	2.73953e-154
NC_015656.1\|WP_013872234.1\|860960_861785_+\|TatD-family-hydrolase	gnl\|CDD\|238635	cd01310, TatD_DNAse, TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.	1.38503e-93
NC_015656.1\|WP_013872236.1\|863193_863919_-\|alkaline-shock-response-membrane-anchor-protein-AmaP	gnl\|CDD\|380217	NF033218, anchor_AmaP, alkaline shock response membrane anchor protein AmaP. The founding member of this family, AmaP (Asp23 membrane anchoring protein), is related to Asp23 through part of its length, but includes a highly hydrophobic N-terminal region that should make it an integral membrane protein. Asp23 (alkaline shock protein of 23 kDa), described in PMID:7864904, is a cytosolic protein in Staphylococcus aureus, strongly induced by a pH shift from 7 to 10, and also recruited to the membrane. AmaP appears to be the partner protein with an integral membrane segment and the ability to anchor Asp23 to the membrane. This model was built to identify full-length homologs of AmaP, while excluding Asp23. Some but not all members of this family score above the cutoffs of Pfam model version PF03780.11, but full-length homologs of Asp23 score considerably higher. Asp23 family members previously were known as DUF322.	1.02788e-10
NC_015656.1\|WP_013872216.1\|830747_832061_-\|cystathionine-gamma-synthase	gnl\|CDD\|236104	PRK07811, PRK07811, cystathionine gamma-synthase; Provisional.	0
NC_015656.1\|WP_083828421.1\|836081_837521_-\|SpoIIE-family-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	1.02358e-38
NC_015656.1\|WP_013872233.1\|859563_860667_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|380561	cd06338, PBP1_ABC_ligand_binding-like, type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions. This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT); however, their ligand specificity has not been determined experimentally.	1.13108e-33
NC_015656.1\|WP_131772115.1\|855858_857421_-\|phospholipid-carrier-dependent-glycosyltransferase	gnl\|CDD\|374423	pfam16192, PMT_4TMC, C-terminal four TMM region of protein-O-mannosyltransferase. PMT_4TMC is the C-terminal four membrane-pass region of protein-O-mannosyltransferases and similar enzymes.	1.81039e-22

>NC_015656.1|WP_043602884.1|850746_851292_+|hypothetical-protein
MPAQGPTAQNGQGGLVMFAKGDRVSPVDDLGGGVWSRCGTVLAVHAAPHREPTPGEERVRVEAAGWLPFEAPRATVLWDDGTAEIIAEDRLLLVYDRVEPLGIRVVTMAMAAPVDVVEHGGHVVLLLREGLLPPPAVQHLREKLRSVRASFVPAGVDGRSPAEIRRRDLDLLRALIAQLTG
>NC_015656.1|WP_013872224.1|848312_850100_-|glycoside-hydrolase-family-15-protein
MRMTGYPPIEEHAVIGDLRTVALVATDGTIDWYCPQRFDGASVFASLLDAERGGSFRIHCPDSRAKQLYLPDSNVLMTRFLAPQAVGEVVDFMVPVDSDVTESPHAVVRQARAVRGRAEFSLRCHPRFDYGRVSHTVTIVDGQGAVFNSPVGSLTLRTAIPLASDGTGVTATFALDMGQSADVVLEWNTPIRPLVDGEAEQLFNRTLTYWQNWLRRSRYHGRWREMVNRSALVLKLLVYRPTGALVAAPTTSLPEELGGIRNWDYRYTWIRDAAFTIYALMTLGFTDEAAAFMDWLEQRCQEAPGDKGLHVLYSVDGNADLDEIVLEHLRGYRDSKPVRIGNGAAGQLQLDIYGELMDSVYLYNKLAAPISFQLWEALSRQLDWLAKHWEEPDEGIWETRGGRQRFTYSALMTWVAFERACRISRQRGLPGPTNEWKEYAGRAYRFVQTAAWDPVRGAYMEHPGSSRLDASLLCMPLVKFSGPTDPRFLSTLDRFGEKLVSDSLVRRYAADGSDGLHGDEGTFNLCSFWYVEALTRAGRVAEARLVFEKMLTYANHVGLYAEEIGPSGEALGNFPQAFTHLALISAALHLDRALG
>NC_015656.1|WP_131772113.1|845681_846497_-|DUF305-domain-containing-protein
MTAVADDSTDGATAERATDAATPAGGRADGPVGGPAGRIRPRARASWVALLAVVAFALVAAGAGLRGLVDRPPGADSVDAGFAYDMSAHHAQAVQMAMVEFRAGADATQRSVAQDIALTQQREIGIMSAWLTSWGLPQVSTAPPMRWMRDSGGHAGHDAGHDAGHDAAGGGSPADTASTAGTAPAGSSRMPGMATDAELAQLSTTQGRELDVLFLTLMIRHHRGGIAMAQYAAAQAQEANVRALARAMVINQAVEIDQMQADLRALGAPPA
>NC_015656.1|WP_193353101.1|843369_844062_+|response-regulator
MRRGRGGGQVTERKGSLVGAVDAEDAHGTERPRSKILLVDDRPDNLMALEAILASLDQDLVTASSGEDALKRLLVDDFAVILLDVQMSGMDGFETAHRIKQRGRTRDTPIIFLTAIDREPHHAFRGYAVGAVDYIAKPFDPWLLRAKVTVFVELFEKNERLAELARARVRDFDLMAEIAERLSALEVLLEGASPSIPEETIAAAAAEVRGLVTRLQPFSRAGGGPPATTS
>NC_015656.1|WP_131772112.1|838997_842978_+|HAMP-domain-containing-protein
MCAGDFSARLGERSGRDALIAQRFDELAALQQRHSGELERVSKVIRRDGRLTERMADLGFEGGWSLSSQAVNSLIDDLARPTHEVARVIAAVAEGDLSQHMALEIAGQPVRGEFLTIGTTVNTMVDQLSSFADEVTRVAREVGTEGNLGGQARVKGVSGVWRDLTESVNSMAGNLTSQVRNIAQVTTAVAQGDLSQKITVDARGEIYELKSTVNTMVDQLSAFADEVTRVAKEVGTEGRLGGQAQVKGVSGVWRDLTDSVNVMAGNLTTQVRSIAEVAAGVARGDLTRQITVDARGEVAALAHTVNTMVEQLSSFAAEVTRVAWEVGTEGNLGGQAHVRGVSGVWRDLTESVNSMAGNLTSQVRNIALVTTAVARGDLSQKITVPAQGEIAELKDTVNTMVEQLSSFAAEVTRVAWEVGTEGNLGGQAHVRGVSGVWRDLTESVNSMAGNLTSQVRNIALVTTAVARGDLSQKITVPAQGEIAELKDTVNTMVEQLSSFADEVTRVAKEVGTEGKLGGQATVDGVAGTWKALTDNVNQLASTLTTQLRAIAEVSTAVTRGDLTRSITVEAEGEVAELKDNINQMIANLRETTEKNAQQDWLKSNIARIGSKMQGQRDLYAVCQMIISEMTPAVGAQLGTVYLLDFIEGDKLRHVAGYGSAPRKRSDGTFLFGEGLIGHAAVEKKGIRVEQVPNGYLYIRSGLGEAPPSDLVVVPVLFEEQVLGVIELASFTRFSELHLHLVDQLVGTIGVVLNTIMANARTEELLAQSQRLTQELRSQSVELQRTNNELEEKAALLEEKNREIEMARIGLEEKAEQLALSSQYKTEFLANMSHELRTPLNSLLLLAKLLADNPEANLTPKQIDFAETIHSAGSELLELINDILDLSKVEAGKMDVEATTVRTTTLCDAVAQIFGPLAEERGLSFEVTVASDVPAEFVTDEQRIQQVLKNLLSNAVKFTDSGEVRLDVTVASDEIAFTAPSLSAAPVALAFSVSDTGIGVAADKLRMIFEAFQQADGTTSRRYGGTGLGLSISKELVRLLGGAIGVASAVGQGSTFTLYVPSVMPSEVLPSTTPGDNEGTIMLSGEPRAAASRRPAGAQGRHPLEGSRLAGRPVGSAGVPGEDADPEPAATTWSSQAGSGKDGPARNGSAAEGPGALSVPAARRSSRSVPGVTGLVTTGMSFLTEAPEEFARPEPVNGLDETDPLVGATVLVVDDDVRNVFALTSALEMHGMRVLYADNGHDAIRLLQQEGSMIDLVLMDVMLPGLDGNETTSTIRQMPAFAALPIVVLTANAMPGDREKSFEAGATDYITKPVDLRHLLSAMRSQL
>NC_015656.1|WP_083828421.1|836081_837521_-|SpoIIE-family-protein-phosphatase
MDGAVHGDLEERIQLVARWMALALGGAHLRRVEERRIGMLSFLAEASDLLAGSLDTDRSLALLARLPVPRLARWCTVHLLRDDGAIKLAAVGHVDEAAAGALSAWADDPVGTLVAHVQAALTDTVRVATVDGAPTVIAAMRARRRVLGVLTLGRAAGNNFEADEIELLTDLARRAAFTVDNARLFRQQVEVAGELQAGLLPPELPHIDGIELGSSYRSARAGLEVGGDFFDLVPDPDGGWTIIIGDVCGKGAEAANVTGVARAVLRLLAGQRHNLPDIMMDLNRALRDTSSYPNPAGQGRFCTLAAAQLRPAGELGPPSEPGPPADEPGWSGGPRPSGARGPTGLARPAARSEARSVERVVSICMAGHPLPVLVRADGTAVFVAQPGTLLGVLDDEDAIFPEVRVSLRAGDALVLYTDGVVEARRGRELFGEERLLATLRGCAGMSAQGIAERLRAAAERFAGGRLRDDVAVLAARIPT
>NC_015656.1|WP_043604699.1|835460_835871_-|ATP-binding-protein
MMTRASSLRPSATHMLVELPYVPAAVPQARRALREQLARTNLSEEAVGTAELLVSELVTNAVKYGKPPVWLLLELRPGLVHASVSDTSVVLPQRQQVDLGSEGGRGLLVLDALAGSWGAVAVDSGKYLWFDLPVQS
>NC_015656.1|WP_131772111.1|833760_835383_-|alanine-racemase
MHWLRGALGARGGAPGRSAHPPDAPTASAAFTGAFTGVQPFAGAYADPISAYIYDLDVAAGNAARLKAALPPWAAIFYAVKANGYPPVLDALAAGHGHGHGAQQAHSAQHTGSTGRSLPTGQGVDGFEVASSHEIQLALDSAQRIGRPARIVVSGPGKSVPLLATLVEAARAGAEMTVNVESPGELRRLNHVAGRAGRQIPVTLRVNPSRVALAGSLRMGGEASAFGIPEADVPDVLAIARSLPWVDVAGFHVHAVSGNLDAAAHLDYVRWCLGYAADTAAAHGVDLRVVDVGGGLGVPFEPDRRGECPFDLDAFAAGLRATPVPAGVRVLFEPGRWLVADCGAYAAEVTDVKHAHGTDFVVLRGGIHHFQLPASWEIVHNFGVVAVDDWPYDFPRPDVAGRPVTVVGELCTPEDTLARDITVDAVRAGDIVVFPMAGAYGYEFAMQGFLGHPPPVRVAVSRDSGGGFTHVHTSSTHHTGSTRHGPAHGGSTYTVSSTHTSSTSTGSAHTSSTHTSSTHTSSTHTGGSHSTWTTRRDERT
>NC_015656.1|WP_013872217.1|832077_833457_-|cystathionine-beta-synthase
MRVYENLAAVVGGTPLIRLNAVTAGIAAPVFAKLEYVNPGGSVKDRIALAMIDAAEAAGQLRPGGTIVEPTSGNTGVGLAIVAAARGYRCVFTMPDKISEEKQAVLRAYGAEVLVCPTAVAPDDPRSYYSVARRVVAETPGAWSPDQYSNPHNPAAHHASTGPEIWADTDGRVTHFVAGIGTGGTISGTGRYLKEVSGRRVQVVGADPEGSVYSGGSGRPYLVEGVGEDIWPTTYDKTVVDRVEAVSDRDSFLMTRELARREGMLVGGSCGLAVVAALRVARELDADGCVVVLLPDSGRGYLSKIFNDEWMYDYGFLDRPSDEPTVAEVLARKSSDATSPPDLVHVHPDETVGAAISYLREYNVSQMPVVRQEPPLRSAEVAGAVIELELLGAVFADRTAVDAPVAAHMSPPLPTVGAGEPLSVLVSALGAAPAVLVLEDGNPVGILTRSDLLSFLATP
>NC_015656.1|WP_013872216.1|830747_832061_-|cystathionine-gamma-synthase
MTSADDPVTSDPVANDPVADNAVTGVDGSAARADGPRRPAPVGAWPAGAEAWAGTGFETVAIHAGQDPDPVTGAVVVPIHPSSTFAQDAVGVPRGAYEYARSSNPTRTALETSLAALEAGAVGLAFASGMAAVDAVLRTVCRPGDHAVIPLDAYGGTYRLFSRVLAEWGVEYTPAPLNDLDAVRAAIRPGRTRLLWSETPTNPTLGVSDIAALADIAHSADALLVVDNTFATPYLQQPLALGADVTVHSTTKYLGGHSDVVGGAAVVADPGLGERLRFIQNATGAVPSPFDAWLVLRGAKTLAVRMDRHCTNARRVAELLAGHPAVAAVHYPGLPDDPGHQVAAKQMRDFGGMVSFALRGGEEAAVEVCRRTRVFTLAESLGGVESLIEHPGRMTHVSVAGSPLEVPANLIRLSVGIESIDDLLEDLTEALPDRRDP
>NC_015656.1|WP_013872226.1|851758_851962_-|hypothetical-protein
MADVSVRFAMTDDSEIVLNLSLTQAIRLTEAIASKVSQAMTEQPPRGSLNGSSYGGPSVRPGPYSTS
>NC_015656.1|WP_013872228.1|852775_854050_+|glycosyltransferase-family-2-protein
MPCLDEEASVGICVARAFAGIADTGLTGEVIVVDNGSTDMSIPVARAAGARVLTESRQGYGNACLVGFAVARGCYLAMGDADSSYDFRELAALVEPLRAGRADHVRGSRFSGKIMPGAMPWSHRYRGNPLLSGMLNRLFGAASSDAHSGMRAFTRAAYERMRPRCAGMEFASELVILAARSGLRVAEVPITDHRRVGVSKLRSLRDGWRHVRFMLPLAPRSLFVIPGLLLLVAGMAGQLVLPLLLPDAGPRRFDVHFWVLSAMVAVLGWQVVLLGVFTDIHNRVSGRAGYSRPPLARGYRYFTLERGLAAGGVLFVVGCAVEAAVLGRWIVTGAGALEQARPGLLAMTVAVLGAGTGFVSFFLHLLTTEGVAAAHGGTGSPRPGEPASGRAPSSRPEDQSPEPGLPSDGAGAPRSGVGTPGDGR
>NC_015656.1|WP_165440835.1|854411_855926_+|hypothetical-protein
MFVVLLAGGALLRATALFACWPALEFYGDSYSYLWYAKELRPGQVRPFGYSAFLKLFSWSPSIAVVPVVQHLLGLGIGAALYGLSVHRGLSRRLAAAAAAPVLLDAYQVNIEQMVMAETLFAALLTAAVLALLWRERPSGSMCAGADALLAAATLTRSVALVLPVLAAVYLLARSVGVRRLVAFGAGVTLPLAAYAAWFAAVYGNFALQNADGFFLWGRVAEFADCSRIQVTPRELPLCSPHPPGERPGPNYYDWDANSPRAAFGPFGAETNTVFRRFALKVIVAQPREYTRLVAHDVTHCFEPVRRVGSRDWYLATWQFRAGHPDPRWQIHRSLRDFDGAVTPRRHDAVLGGLLRGYQSVGFTPGPLLAGCVLMGVLAAMAAAGYGLLRIRQDCLLLVGMGLVLLVVPCATAVFDYRYLLPVLVCLPPAGAFAVAQLRLVRARTRPAGRRAGPDLPTRPEPPPGPPPDLVGRAGRTGWRRRVRSSRGTTSSPATPRSGSPAPP
>NC_015656.1|WP_131772115.1|855858_857421_-|phospholipid-carrier-dependent-glycosyltransferase
MPTDRLAGWLASLAIAAVAGVLRFWQLTEPRGIYFDEVYYTHDAYGLLTHGYELSDIKSGCDGPGFVVHPPLGKWLMAVSEWLFGYTDCAGIRHGSPELGWRFASAVAGTLAVLVLARIARRMFRSTLLGCFAGLLLAFDGLAFVQSRIGILDIFLMTGLVLALACLVLDRDHGRARLAAGLVDASNIPLGGQASKDVSEAGNDNQESLSSLYKTDSNKLRFGARLGARPWRLACGLCLGASLGVKWSAVYTLVGFAALAIAWDAGARRTAGARRPVLAAVRRDGPQWFVSFIPLPVIVFFATWTGWFVTDGGYNRHRFGDGVWAALHGWWYYQQQIFHFHEHLDASHPYASKPLSWLVLGRPVAYFYSTPKAGEPGCTSPAGCSREILAIGNPAIWWVGVLALVGVLALWVSRRDWRAGLVLVGFTTSFLPWLAFPNRTMFLFYALPLLPFLILGLTALAGVALGPRTASDLRRLVGSLTVGIYAIVVVLLFVYFYPIMAAQVIPTSAWRVRMWFPGWI
>NC_015656.1|WP_050803318.1|857571_858480_+|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase
MSGTLVLCGAPIGDVRDASPRLGEVLARADIVAAEDTRRLRRLTAALGVTITGRVVSCFDANESSRADFLLSHLRAGATVALITDAGMPAVSDPGFRVVAAAVTAGVAVTVVPGPSAVTAALAVSGLPTDRWVFEGFLPRRPGERRSRLAELAGERRTLVILEAPHRLPATLDDLTAAFGPDRAAVMCRELTKTWEEIVRDDLGALAAWAREREIRGEITLVVAGRPGTSSQPQPQPGTPAAAVLSAALAAEVAAREAAGIPRKTALVAVAAEHGVPRRFVYDAVLAAKNDRSRTDRGHQRG
>NC_015656.1|WP_043604710.1|858757_859228_-|hypothetical-protein
MFLTATGRLFVWPVRDAPEPVDAIVMYAGSPGRLARAIELVRAGYAPVLAVSTPPGADDPCPAALPGIQVICFRPDPVTTQGEARMTAELATRYGWRSVMIVVGTPQDTRARLRVKRCYEGRALFVTVSPRLRGWPYAISYEWAAMIKALTIQRNC
>NC_015656.1|WP_013872233.1|859563_860667_-|ABC-transporter-substrate-binding-protein
MSSSLAVALVTPLTGPAAVHGLTTLRAVTLWARDEQLPPPWDDINVTAYDAHPHPAAAMRAAAAARPDVIFGPYGQRSALAACAATDRVVFNIGAPSTRFVRQAFPNVVNLLSPHSTWTRGLLAAVRAADRQARRVTVLLASDDRALEVVSVVRAAAARLGFEVASSVFRPGRVMIAARRLPPADVLIVQGDPDDENAAAEVLLRRPWRAAAFSTAGHDGALTALRDRRDGLLGPRAWSPRLPADAGTGPSVSEFVACYQRMYDQLPAATAAVAYAAGLVLGRCVWASGRADDPHVLAAARTLDTSTLLGRFRLDEATGLQVGHHSHLVQWRDDVAHVVWPADRAQSPLAYPRSRIGVARQHAMTAS
>NC_015656.1|WP_013872234.1|860960_861785_+|TatD-family-hydrolase
MARDGGRRGDPPPEPPPLSVEVIDSHCHLDIMGGDVAVAVAAAQAVGVRRLVTVGVDLPTSRWQAQVAAGHPDVYAAVAIHPNEAASGVDEETFTEIAELAAAPKVRAVGETGLDYYRTPAERHTAQQDSFRRHIVIAKQTDRTLMIHDREAHEDTLRILAEEGAPERVVFHAFSGDEAMAKVCADAGYVMSFAGNVTFNNAQRLRDAAAVAPRDLLLVETDAPFLTPVPWRGRPNGPYLIPLTLRVLAAARGEDVDALASAIAATSERMFGPW
>NC_015656.1|WP_013872235.1|861898_862858_+|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA
MDSSSTGSSAPLSSGGSSSGSGLPDGLLTPADVRSISAAVGIRPTKRRGQNFLVDPNTVRRLVRLAGVEPDETVLEIGPGLGSLTLGLLPAARRVVAVELDEALATALPATVTARLGPAVAARLTVLAADGLRLEPADISGDPPSVLAANLPYNVAVPLLLGVLERFPSVRRGLVMVQAEVADRLTASPGGRVYGVPSVKMAWYASARPAGPVPRAVFWPQPNVDSSLVAFSRHDRQGSPRLRRAVFAAVDAAFAQRRKTLRAALSGWAGSADQAERLALAAGIDPSARGEILDVAAFTRLALARLDPESRIGIETEAE
>NC_015656.1|WP_013872236.1|863193_863919_-|alkaline-shock-response-membrane-anchor-protein-AmaP
MSGTAISVSDDPWADSPIPRLGALTKPSEVENVANVEEPVRSGPARSRRHPATHRVDRFNRVILTLLGLTLLGAGVVILLAGNGVFGTEATDQPIPTPGNRSFANSHSWFWPVVGVATTVVVLLALIWLSAQFSSSRLSRLHVTDDRFGHVQVDGQDFAAAVENELAGADGVRQVHARLLGSEKQPLLQVVVTVRPDADVHRIRSAIEEVALPYVRGTVARPRLAVELKLVPDAHHDSRVR

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_015656_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015656_4

1161340-1161423

Orphan

Consensus_repeat	Method
GCCGCGTGGGGAAGGAAAGGGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015656_4

>merge|NC_015656|4|1161340-1161423|CRISPRCasFinder
GCCGCGTGGGGAAGGAAAGGGGCGCCTGGGCGATCGGCATCAGCGCGGGCTGTGCCGTGGTGCCGCGTGGGGAAGGGAAGGGGC

>NC_015656|4|4|1161340-1161423|CRISPRCasFinder
GCCGCGTGGGGAAGGAAAGGGGC	GCCTGGGCGATCGGCATCAGCGCGGGCTGTGCCGTGGT
GCCGCGTGGGGAAGGGAAGGGGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015656.1\|WP_013872478.1\|1163804_1165559_-\|succinate-dehydrogenase-flavoprotein-subunit	unknown	unknown	gnl\|CDD\|236185
NC_015656.1\|WP_083828147.1\|1173842_1174436_+\|cytidine-deaminase	unknown	unknown	gnl\|CDD\|180142
NC_015656.1\|WP_013872468.1\|1147916_1149185_+\|NADP-dependent-malic-enzyme	unknown	unknown	gnl\|CDD\|223358
NC_015656.1\|WP_131796168.1\|1161428_1162358_-\|hypothetical-protein	unknown	unknown	unknown
NC_015656.1\|WP_013872465.1\|1146095_1146491_-\|superoxide-dismutase,-Ni	unknown	unknown	gnl\|CDD\|378114
NC_015656.1\|WP_043604912.1\|1159869_1161129_-\|IS4-family-transposase	unknown	unknown	gnl\|CDD\|379017
NC_015656.1\|WP_013872472.1\|1151192_1154948_-\|multifunctional-oxoglutarate-decarboxylase/oxoglutarate-dehydrogenase-thiamine-pyrophosphate-binding-subunit/dihydrolipoyllysine-residue-succinyltransferase-subunit	unknown	unknown	gnl\|CDD\|237030
NC_015656.1\|WP_013872480.1\|1166025_1166421_-\|succinate-dehydrogenase,-cytochrome-b556-subunit	unknown	unknown	gnl\|CDD\|239581
NC_015656.1\|WP_193353104.1\|1146690_1146966_+\|S24/S26-family-peptidase	unknown	unknown	gnl\|CDD\|119396
NC_015656.1\|WP_013872477.1\|1162657_1163422_-\|succinate-dehydrogenase-iron-sulfur-subunit	unknown	unknown	gnl\|CDD\|235652
NC_015656.1\|WP_013872471.1\|1150962_1151139_-\|hypothetical-protein	unknown	unknown	unknown
NC_015656.1\|WP_013872485.1\|1174432_1175716_+\|thymidine-phosphorylase	unknown	unknown	gnl\|CDD\|180276
NC_015656.1\|WP_013872481.1\|1166822_1168808_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_015656.1\|WP_013872482.1\|1168915_1171351_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_015656.1\|WP_013872470.1\|1149801_1150776_+\|zinc-binding-dehydrogenase	unknown	unknown	gnl\|CDD\|176227
NC_015656.1\|WP_043604908.1\|1146926_1147544_-\|dTDP-4-dehydrorhamnose-3,5-epimerase	unknown	unknown	gnl\|CDD\|376414
NC_015656.1\|WP_043602982.1\|1171573_1173466_-\|hypothetical-protein	unknown	unknown	unknown
NC_015656.1\|WP_013872479.1\|1165588_1166026_-\|succinate-dehydrogenase-hydrophobic-membrane-anchor-subunit	unknown	unknown	gnl\|CDD\|239580
NC_015656.1\|WP_131773848.1\|1158076_1159573_+\|acetamidase/formamidase-family-protein	unknown	unknown	gnl\|CDD\|225279
NC_015656.1\|WP_083828146.1\|1155160_1157395_+\|hydantoinase/oxoprolinase-family-protein	unknown	unknown	gnl\|CDD\|223223

Protein	Function_ID	Function_description	E-value
NC_015656.1\|WP_013872478.1\|1163804_1165559_-\|succinate-dehydrogenase-flavoprotein-subunit	gnl\|CDD\|236185	PRK08205, sdhA, succinate dehydrogenase flavoprotein subunit; Reviewed.	0
NC_015656.1\|WP_083828147.1\|1173842_1174436_+\|cytidine-deaminase	gnl\|CDD\|180142	PRK05578, PRK05578, cytidine deaminase; Validated.	2.28555e-59
NC_015656.1\|WP_013872468.1\|1147916_1149185_+\|NADP-dependent-malic-enzyme	gnl\|CDD\|223358	COG0281, SfcA, Malic enzyme [Energy production and conversion].	6.7034e-179
NC_015656.1\|WP_083828146.1\|1155160_1157395_+\|hydantoinase/oxoprolinase-family-protein	gnl\|CDD\|223223	COG0145, HyuA, N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	0
NC_015656.1\|WP_013872465.1\|1146095_1146491_-\|superoxide-dismutase,-Ni	gnl\|CDD\|378114	pfam09055, Sod_Ni, Nickel-containing superoxide dismutase. Nickel containing superoxide dismutase (NiSOD) is a metalloenzyme containing a hexameric assembly of right-handed 4-helix bundles of up-down-up-down topology with an N-terminal His-Cys-X-X-Pro-Cys-Gly-X-Tyr motif that chelates the active site Ni ions. NiSOD catalyzes the disproportionation of superoxide to peroxide and molecular oxygen through alternate oxidation and reduction of Ni, protecting cells from the toxic products of aerobic metabolism.	1.97044e-61
NC_015656.1\|WP_013872477.1\|1162657_1163422_-\|succinate-dehydrogenase-iron-sulfur-subunit	gnl\|CDD\|235652	PRK05950, sdhB, succinate dehydrogenase iron-sulfur subunit; Reviewed.	5.36783e-145
NC_015656.1\|WP_013872472.1\|1151192_1154948_-\|multifunctional-oxoglutarate-decarboxylase/oxoglutarate-dehydrogenase-thiamine-pyrophosphate-binding-subunit/dihydrolipoyllysine-residue-succinyltransferase-subunit	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	0
NC_015656.1\|WP_193353104.1\|1146690_1146966_+\|S24/S26-family-peptidase	gnl\|CDD\|119396	cd06462, Peptidase_S24_S26, The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the repressor of genes in the cellular SOS response to DNA damage; MucA and the related UmuD proteins, which are lesion-bypass DNA polymerases, induced in response to mitogenic DNA damage; RulA, a component of the rulAB locus that confers resistance to UV, and RuvA, which is a component of the RuvABC resolvasome that catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. The S26 type I signal peptidase (SPase) family also includes mitochondrial inner membrane protease (IMP)-like members. SPases are essential membrane-bound proteases which function to cleave away the amino-terminal signal peptide from the translocated pre-protein, thus playing a crucial role in the transport of proteins across membranes in all living organisms. All members in this superfamily are unique serine proteases that carry out catalysis using a serine/lysine dyad instead of the prototypical serine/histidine/aspartic acid triad found in most serine proteases.	3.57612e-12
NC_015656.1\|WP_043604912.1\|1159869_1161129_-\|IS4-family-transposase	gnl\|CDD\|379017	pfam13006, Nterm_IS4, Insertion element 4 transposase N-terminal. This family represents the N-terminal region of proteins carrying the transposase enzyme, DDE_Tnp_1 (that was Transposase_11), pfam01609, at the C-terminus. The full-length members are Insertion Element 4, IS4. Within the collection of E.coli strains, ECOR, the number of IS4 elements varies from zero to 14, with an average of 5 copies/strain.	3.58579e-39
NC_015656.1\|WP_013872481.1\|1166822_1168808_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	4.17797e-99
NC_015656.1\|WP_013872485.1\|1174432_1175716_+\|thymidine-phosphorylase	gnl\|CDD\|180276	PRK05820, deoA, thymidine phosphorylase; Reviewed.	0
NC_015656.1\|WP_013872482.1\|1168915_1171351_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.12258e-98
NC_015656.1\|WP_013872470.1\|1149801_1150776_+\|zinc-binding-dehydrogenase	gnl\|CDD\|176227	cd08266, Zn_ADH_like1, Alcohol dehydrogenases of the MDR family. This group contains proteins related to the zinc-dependent alcohol dehydrogenases. However, while the group has structural zinc site characteristic of these enzymes, it lacks the consensus site for a catalytic zinc. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site, and a structural zinc in a lobe of the catalytic domain. NAD(H)-binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	1.36885e-91
NC_015656.1\|WP_043604908.1\|1146926_1147544_-\|dTDP-4-dehydrorhamnose-3,5-epimerase	gnl\|CDD\|376414	pfam00908, dTDP_sugar_isom, dTDP-4-dehydrorhamnose 3,5-epimerase. This family catalyze the isomerisation of dTDP-4-dehydro-6-deoxy -D-glucose with dTDP-4-dehydro-6-deoxy-L-mannose. The EC number of this enzyme is 5.1.3.13.	5.05574e-83
NC_015656.1\|WP_013872479.1\|1165588_1166026_-\|succinate-dehydrogenase-hydrophobic-membrane-anchor-subunit	gnl\|CDD\|239580	cd03500, SQR_TypeA_SdhD_like, Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential quinones such as menaquinone and thermoplasmaquinone. SQR is also called succinate dehydrogenase or Complex II, and is part of the citric acid cycle and the aerobic respiratory chain. SQR is composed of a flavoprotein catalytic subunit, an iron-sulfur protein and one or two hydrophobic transmembrane subunits. Members of this subfamily are similar to the Thermoplasma acidophilum SQR and are classified as Type A because they contain two transmembrane subunits as well as two heme groups. Although there are no structures available for this subfamily, the presence of two hemes has been proven spectroscopically for T. acidophilum. The two membrane anchor subunits are similar to the SdhD and SdhC subunits of bacterial SQRs, which contain heme and quinone binding sites. The two-electron oxidation of succinate in the flavoprotein active site is coupled to the two-electron reduction of quinone in the membrane anchor subunits via electron transport through FAD and three iron-sulfur centers. The reversible reduction of quinone is an essential feature of respiration, allowing transfer of electrons between respiratory complexes.	6.73474e-39
NC_015656.1\|WP_131773848.1\|1158076_1159573_+\|acetamidase/formamidase-family-protein	gnl\|CDD\|225279	COG2421, COG2421, Predicted acetamidase/formamidase [Energy production and conversion].	9.60748e-47
NC_015656.1\|WP_013872480.1\|1166025_1166421_-\|succinate-dehydrogenase,-cytochrome-b556-subunit	gnl\|CDD\|239581	cd03501, SQR_TypeA_SdhC_like, Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential quinones such as menaquinone and thermoplasmaquinone. SQR is also called succinate dehydrogenase or Complex II, and is part of the citric acid cycle and the aerobic respiratory chain. SQR is composed of a flavoprotein catalytic subunit, an iron-sulfur protein and one or two hydrophobic transmembrane subunits. Members of this subfamily are similar to the Thermoplasma acidophilum SQR and are classified as Type A because they contain two transmembrane subunits as well as two heme groups. Although there are no structures available for this subfamily, the presence of two hemes has been proven spectroscopically for T. acidophilum. The two membrane anchor subunits are similar to the SdhD and SdhC subunits of bacterial SQRs, which contain heme and quinone binding sites. The two-electron oxidation of succinate in the flavoprotein active site is coupled to the two-electron reduction of quinone in the membrane anchor subunits via electron transport through FAD and three iron-sulfur centers. The reversible reduction of quinone is an essential feature of respiration, allowing transfer of electrons between respiratory complexes.	6.63155e-42

>NC_015656.1|WP_043604912.1|1159869_1161129_-|IS4-family-transposase
MVRLRQVVELPAVENERLTDRISIGVLARIVPRDLIDEVLVETKRQERRTRLLPARVMVYFTMAMCLFFDDDYEEVMRKLAGGLMWLGNWKGDWKVPTTGAISQARTRLGAAPLKLLFERVAVPVAGLGTKGAWLRSRRLMAIDGFFLDVADTPENATAFGRSTNGYKASALPQVHVVALAECGTHAIVSAAVGPRASDEHALAAALFDACEHGMLLTADRYFYSFDLWRQALDTGADLLWRVSSNLTLPVIQPLPDSSYLSIIVNPKIREKKRNQLIADARAGHDLPEDSAIPVRVIEYTVPDRTGSGTGELICLVTTIIDHADIPAVELATAYHERWEIENIFDEVKTHQRGEARVLRSKLPDLVEQEIWALLLSHYAIRSLMREAADEADVDPDRLSFMRSLRVVRQVTDQADFSP
>NC_015656.1|WP_131773848.1|1158076_1159573_+|acetamidase/formamidase-family-protein
MALQPGKGKMDGRHYLPSTPETILWGRLPTADTRPVLSVESGATATVDTVSQEGILDDQGRDPDAFFGRFGVPASEVLDDARMIASSGIPHRFGVDSPHLVTGPVFVRGAEPGDVLRVDVVSLHPRARYGVVSTRHGAGLLAGEFPENDPPGPDANARNWAAFRTTSSFCAVERRRGRLFGALEVSKGRKVRFPLSPFMGIMSVAVDSPGPVRSTSVGIHGGALDCGELGIGSRLFLPVRVSGALFAVGDPHYSLGDGKVAAGGLEGPLRATFRLTVLKEPAARAALGTLRAPFAETDTHWVPLGAQADLTDAARQTTRSAVLFLSSRLGMDRADALAYLSAAAVFGIGRSGSDLQTVYCRIRRADFGEPAAAKPRLVRPGFGRAAPTPAPDSSAPSNSVPDSSVLGTPAPGSSTAGSSPPASVAGPVSADERSEEPLAAGTAHEPPDTPRPASDASGPAVPDPAAASPAASRSAADTSAPPNAPIAEPDNAGPAPQP
>NC_015656.1|WP_083828146.1|1155160_1157395_+|hydantoinase/oxoprolinase-family-protein
MVFDAVTVGLHPGRCRRRSVPDGWERAAATCQDRHVAVWLGVDVGGTFTDLVAVGDDGRMIFGKVPSVPADPSEAVLDAVRGAGLAGPLAGSGPGRGGAAGVVERFAHGTTVATNALLERRGARTALVTTHGFADIIEIGRQNRPALYDLTRDRPPPLVPRELRYTVVERTGPDGVIVPLDAHSLRDVVAALTALSAVAMAGGTPAVADADGAVRPLAAVAVCLLFSFAHPEHEHQVADALRAALPGVTVVASHEVLPRFREYERFATTVADAYLTPTLSTYLGALARRCAAAGLPSPLVMRSSGGVVELAAAAEHAAACVLSGPAGGVVGAAYVAARSGLADLLTFDMGGTSTDVAPVIGGRVQTTAEAVLAGIPVTLPTVDVHSVSAGGGSVAWVDSGGALRAGPRSAGADPGPACYGRGGVEPTVTDADLVLGYLVDGASLGGEVTLSRAAASKALAALGAMLGSGPHGLSVEETAAGVVAVADAEMIRALRVVSVERGLDPRELTLVAFGGAGGTHACALAEELGMRRVLVPLACGVLSALGLAIGDVRRDYLRPLHGPLATADLDAALAELARAAHADTLAADIPALVIEHQVDCRYVGQSHELTVVATADGDGDSAGGGFSVARIRAAFEAEHLRRYGHTAPDRDVEVVAVRLVATVPGRRPELRAPAADPTAARTRRPIYLDGSWREVDVVPRAALGPGDTVTGPAVVEFPEATCLIRPTWHAQVDPAGSLLLTRVH
>NC_015656.1|WP_013872472.1|1151192_1154948_-|multifunctional-oxoglutarate-decarboxylase/oxoglutarate-dehydrogenase-thiamine-pyrophosphate-binding-subunit/dihydrolipoyllysine-residue-succinyltransferase-subunit
MAAPTVPESGPDFGPNEWLVFEIYQQYLADPESVSPQWREFLSDYRPEGVNGQPGVAGPVPPAVADGAVPAAGGVPDAVPAGQPATAPTAATPVTPAAPVASAAPVASAPAATAVPAATAVPTAGQSAPAADGGVPTSPLRGAAARVVANMETSLHVPTATSVRAVPAKLLADNRIVINRHLARSRGGKVSFTHLIGYAMVRALQATPVMNHSYTEVGGKPALVTPEHVNLGIAIDLVKGSSRQLVVVAIKQAETMDFSQFWLTYEDLIRRARTNKITADDFANVTITLTNPGGIGTVHSVPRLMQGQGTIIGVGAMEYPAEFQGASQETLSRLAVSKIITLTSTYDHRIIQGAQSGEYLRRIHQLLLGADDFYEEVFRSLRVPYEPVQWVADITSSHEGDLDHGTRVLELIHAYRVRGHLMADTNPLEFAIRSHPDLDIISHGLTLWDLDREFPVDGFAGQRTMTLRDILGVLRDSYCRRVGIEYMHIQEPDERVWIQQRVERSAERPDPAEQLHVLERLGAAEAFESFLQTKYVGQRRFSLEGGESAIPLLDEVLQRASEAGMDEVAFGMAHRGRLNVLANIIGKSYRQIFAEFEGYVDPQTAHGSGDVKYHLGAEGVYTTPDGREVAVSLVSNPSHLEAVDPVLEGVVRAKQDLLNKGPEGFTVLPVLIHGDAAFAGQGVVAETLNLSQLRGYRTGGTVHLVINNQVGFTTSPVSSRSSVYATDVARMVQAPIFHVNGDDPEACVRVARLAVEFRQAFHKDVVIDMVCYRRRGHNEMDEPSFTQPLMYDTIATKRSVRKLYTEALIGRGDITPAEAEQAMKDYSAQLEKAFAETRDTTSRPASQPRLVTTPAEAAAAAAVSTAVSLDVVKKIIDTQTTLPEGFTVHPRLRPQLERRAQMVATGAIDWACAETIAFGSILLDGRPIRLAGQDSRRGTFGQRHAVLVDRHTGEEYSPLKSLEVESGAGTFYVHDSLLSEFAAMGFEYGYSVARPDALVLWEAQFGDFANGAQSIIDEFIAAGEAKWGQRSAVGLLLPHGYEGQGPDHSSARVERFLSLCAENNMLVSAPSSPASYFHLLRRQALSPVRRPLVVFTPKSMLRLKAATSTVEELTGGSWLPVIDDASVGDHAGIRRVLLSSGKVYYDLLATRAKKEITGTALVRVEQLYPTPVAELRAVLATYPNLTEVTWVQEEPANQGAYPHMAIHLPEALPAGLVLRRASRNASAAPASGSSSRHEKEQAELLGQAFAG
>NC_015656.1|WP_013872471.1|1150962_1151139_-|hypothetical-protein
MYFTDRGVEELSQRRGEESVTLDWLADQLRTFVDLHPQYEDAVEELATYLARLDDLDD
>NC_015656.1|WP_013872470.1|1149801_1150776_+|zinc-binding-dehydrogenase
MLAVAAVSQNADDPLSGLDVGEQPAPDVPDGWTTVSIRAATLNHHDLFSLRGVGLPADRLPMILGCDAAGVSADGDEVIVHAVIGDPAAGGGDETLDPRRTLLSELYPGTLAEAVAVPRRNLVPKPPALSFEEAACLPTAWLTAYRMVVHRSALPAAGGGTLLVQGAGGGVSTAAIILGKAAGHTVLVTSRDAAKRERALKIGADEAFEPGARLPVRVDAVIETVGAATWGHSLRSLRPGGRIVCSGTTTGANPPAELNRLFFLQLSVVGSTMGTRDELAELAAFIDRTGVRPLVNDVRPLADARASFAKLVRGDVFGKLVLTV
>NC_015656.1|WP_013872468.1|1147916_1149185_+|NADP-dependent-malic-enzyme
MTATTDHSVNQAVPDALGDLPPAVPRPAVASDGPGSLARDIDPVFTLHRGGKIGIALTVPLNDREDLSLAYTPGVARVCTAIADEPGLADDFTWRSNVVAVVTDGTAVLGLGNIGPAAALPVMEGKAALFKQFAGVDAIPICLDCTDTEQIVETVARLAPSFGGINLEDISAPRCFAVERLLQDRLDIPVFHDDQHGTAIVALAALENAARLTGRRLDDLRAVVSGAGAAGLAVTRILLAAGIGDIAVGDSRGILHPDRADLTPVKAEIAATTNRAGISGSINAALAGADVFLGLSSGTVPEAAVASMAPDSIVFAMANPDPEVDPEVARRHARVVATGRSDYPNQINNVLAFPGVFRGALDVRASRITESMKLAAADALAAVIADELTEEHIIPSVFDDRVAPAVAAAVARQAHADGVARR
>NC_015656.1|WP_043604908.1|1146926_1147544_-|dTDP-4-dehydrorhamnose-3,5-epimerase
MEVHELEIAGAWVFTPRQHTDDRGTFLEWFRSETVVEAVGHPLHLAQANHSVSRRGTLRGIHYAAVPPSQAKYVTCVHGRVLDCVVDIRLGSPTYGTHQAVLLDDVDRKGLYLAEGLGHSFMALTDNAAISYICSTPYSPAREYGIDPLDPDLTLPWPRDVAPLLSEKDARAPSLKEAEAAGLLPSYSACTAYYETLRIQAGHGQ
>NC_015656.1|WP_193353104.1|1146690_1146966_+|S24/S26-family-peptidase
MTPTLRDGDACVVLWGMSPRVGDVVVARLPGRGLGVKRAAFVEPDGSWWLRSDNVAAGTDSATFGSVPAEDVLGRVIARYWPWPAWIRRVS
>NC_015656.1|WP_013872465.1|1146095_1146491_-|superoxide-dismutase,-Ni
MSLLRPKTTVSAHCDLPCGVYDPAQAKIEAQSVKAIQEKYQSNDDPAFRARALTIKEERADLVKQHLWVLWTDYFKPNHLEKYPELHDLFWQATKAAGAAGAKGSVDPADGQKLLDLIERISTIFWETKAA
>NC_015656.1|WP_131796168.1|1161428_1162358_-|hypothetical-protein
MFGRLGFFGFSHSDFSHSDFSRAARVTASALALLAPGLLLAAAGCSSDDSPAPPPAIPTNVAPTEINGVPAPLTDAYQATINRGTARIRFSDQANFVSSSGRRQISITGTGTVDFVNSASQTVRDVAGGGRSELLVVGSDLYQRSVPPADVPNPPRWTRVIPGASGSRPATPAPTPTTQPTTGDAVALRLGFLSGASAPVTTVGQETIDGATTTHYTLSVNLDTAATRGNISATTVEYYKNTLGTAIQPTEAWIDTDGLIRQLRVTVATSSTGADTSAGRSEIVRTVTYSDFGVPPHITAPSPDQIAPG
>NC_015656.1|WP_013872477.1|1162657_1163422_-|succinate-dehydrogenase-iron-sulfur-subunit
MTVTDDLSTTVPAGASPSTSDGRTITLKIRRYNPEESDKAYWQSFAVPFVPSDRLLDALHYVKWNLDGSLSFRRSCAHGVCGSDAMRINGANRLACKVLVKDLGSEISIEPIKGLPVEKDLIVNMEPFFDAFRAVKPYLIPEGHEPTKERLQSAADRERFDDTTKCILCAACTTSCPVFWNDGDYFGPAAIVAAHRFIFDSRDAASDERLEILNEREGVWRCRTTFNCSNACPRGIQVTKAIAEVKRALIFRRI
>NC_015656.1|WP_013872478.1|1163804_1165559_-|succinate-dehydrogenase-flavoprotein-subunit
MQIHKFDTVIVGAGGAGMRAALESGKRCRTAVLTKLYPTRSHTGAAQGGMCAALANVEEDNWEWHTFDTIKGGDYLVDQDAAEVMCKEAIDAVLDLEKMGLPFNRTPEGRIDQRRFGGHTRDHGKAPVRRSCYAADRTGHMILQTLYQQCVKHDIEFYNEFYVLDLLLNGGVAAGVVAYELATGEVHVFQAKSVVFATGGFGKVFKVTSNAHTLTGDGMGIIFRRGLPLEDLEFYQFHPTGIWKMGILLTEGARGEGGILRNKDGERFMERYAPTIKDLAPRDMVARAIYTEIRAGRGCGVDGDHVYLDLTHLPPEQLDAKLPDITEFARTYLGIEPYTDPIPIQPTAHYAMGGVPTNINAEVLRNNTDIVPGLYAAGEVACVSVHGANRLGTNSLLDINVFGRRAGIAAAAHANEVPTHAELPDDPAAFVEGLLSRLRDGSGTQNVAAIRRELQETMDVNASVYRTEATLKQAVGDIAGLKARYQNVGVTDRGHRYNTELLEAVELGFLLDLAECLVTSALARNESRGGHSREDYPNRDDVNFLRHTMAYRSGPLAAASPDSEIRLDYKPVAMTRYQPMERKY
>NC_015656.1|WP_013872479.1|1165588_1166026_-|succinate-dehydrogenase-hydrophobic-membrane-anchor-subunit
MATTIDGAAAPAIEAPRSPQRRPVRTKARTNFELYAWLFMRVSGILLVFLVLGHLFIMNILDGGVQRIGFGFVAGRWASPFWRTWDLLMLVLAELHGTNGLRTVINDYAERPQTRFWLKMLLYVSAFLVISLGSLVIFTFDPNIS
>NC_015656.1|WP_013872480.1|1166025_1166421_-|succinate-dehydrogenase,-cytochrome-b556-subunit
MPKAPAGTLYRGREGMWSWVAHRITGVLIFFFLFAHVLDTALVRVSPSSYDTVIATYKNPVVNLLEVGLVAAVLFHALNGIRIVLIDFWASGPRFQRQMLYTEIVLWVILVVPGTFYMLKHTVETLFGSAS
>NC_015656.1|WP_013872481.1|1166822_1168808_-|serine/threonine-protein-kinase
MARSAPPPGDPARHNTPRYVSQRYRLDTPIGRGGAGVVWCGEDELLQRPVAVKEILIPHTGSQVERDGLRARVLREARALARLNSPAIVSVYDVVEEAERHWIVMELVDADSLGEVIRAEGPLPPDQVAAIGLTLIEALAAAHSAGVLHRDIKPGNVLLGRDGHVRLTDFGIAATDGDSTLTGTGALVGSPAYIAPERVRGSSGTPASDLWGLGATLYAAVEGQPPFEGPETYAVLTAVVEGRRRPFQLAGPLHGLLGDLLDRPAESRPDVAEVRRRLRPIAGGVVPVPASVTGSDAEPVTEAVADAARKSGPGPAVGAVEHASGDPASGGDARVRGPRATPPVTGAPTAGPATVDRSVGGPAEDGGPMAGGAAEDPTEAGTLVARRAAAAATAGTDAPSTGRAASAPATSARRDRAGSPEEPATAVAVRTRVGGAPLLDTSAATTLAGNRFTPPPFDFGGYGVGSQDDPDDGLLPVTSSAVGGPPGNSTIHDHLESGRTSTGWWRDRTPLRRGALAAVAASVVICVALVIGTVLRSGPETDVQLQPGGDTSPSVSGVAGQHSVNPSALTSSLKAPVGVDRIPTSRPSSPPVASTPAEPPPTATEPPPVTPSPTQVGASPTAPASPTSPPSRTPTQEPSTPPTEPPPPPPSGGAPPPAGGV
>NC_015656.1|WP_013872482.1|1168915_1171351_-|serine/threonine-protein-kinase
MPLERHPTSKTGQEPDSGQLVAGRYRLGAELGRGGFGVVYAATDELLRRDVAVKEIRLPPSISADERAILRQRVLREARSAGRVQHPGLVPVFDVLEADGRPWIVMELVEGRSLAEIIYDEGPLPRERVARIGISLAYALEAAHRTGIVHRDVKPANVLISADRRARLTDFGIALSAGDPTLTRTGILLGSPSYIAPERARGEAGGPGSDIWALGATLFTAVEGGTPYERDSAIATLTAIVEGRRHPFRLAGALAPILADLLAVQPADRPSLSLTRRRLRKVSEWEASRRLPGTRAGRTDRERPPRAPAGHSGAAPGTIPAGTVPAGEDPAHTTGADDPVGATPTSTSGPTAGSPTAGGPTAGSPAAGGSTPPAGGTAPAGDATPDSTEAGHQRAGRPVDTPALDIPTLDAPAPDIQAAVSAAAAARQPAAPPAEELATSPAGEPATSPAGKTEEPATPPAHTRQQAPPARSGPAKTAAEPTGTATPPADLQDQPPTARPGPAKTSEPAEPAGTVSSAATPGTAAAAATTGAAQTPGSVRTARTTTAAEPGEPGVAGLTGAAAADRPNRRRLGMIAAVLAAVLAGTVIVLAAALTSDPDRLGAGRLPAAAATGQGASGGTTTGQATPTITGPPTSAQASPGASITAATVTADPGVAPLDSTPAPPPPGWRTYSGPSGWSIAYPDGWEERPAPGNEGRNFTNPQTGAYLHIDVTQQANPSALADWTAHEDGLSAQVPDYRRVKIAPSDGGDGAIQADWEFTHASGGKTVHVLNRGFVRNGHGYALYWRTADSRWETDLPLMWQLFSTFRPGP
>NC_015656.1|WP_043602982.1|1171573_1173466_-|hypothetical-protein
MAALTRCRPQEDALDPADTDTPAAGEKATPLTVRRAAPAPEPGATPVTEPAATGGTAVRGRRRGRLRTHTLIGSSYLLLALLLTARVWSDPTRNIISGNPNDTSLYCWWLAHTAHAVTHLSNPFVTHLANAPEGINALWNTSVLVPGLLLTPVTRAAGPVASYNLLVMLAFSLSAFSAYLLARKLRVRTAAAYVAGLVYGFSPALVAAGTGHLSLALAPAVPLLLGLVVDAVRGTHRPARTGVPLGVGVGLQLLTGEEVLFITAVTAAVGIVLLLVSRPEYLRLAGGPLRTFAIAFLTCLALTAVPLSIQFLGSLRAHGSPFLANFFKSDLTGLYVPSEHQWLATSAQSTRAAEFPGGASEYMNFLGWPLLIVCVCTVVLGFHDLRIRIAGLTGTVLAVLSLGETLLVNNVETGLRLPWGLVAGLPVFEAALPNRFSLGTALMAGLVLACALDRLPARLAAAGVPAAVALSVVCVLPLIPRPYTVERSPDVPAFFTTDAVKTLPAGSNVLLLPYPTGLRATAMSWQTVADFHFSMPGGYFIGPGHDGKAYMGGKKPTVTAQLLEDIESGSFTGPVTPAQIARSRADFAELGMRAVVLGPARHRDGLRDTVTSLTGQPPEFTGGVYVWRLP
>NC_015656.1|WP_083828147.1|1173842_1174436_+|cytidine-deaminase
MAAGSAPGGGPEGGTGAGPVIGSVDGITAGPAGASAVDAVDWRWLRAEAARVAACAYAPYSRLHVGAAAVVDDGRLVVGCNVENASYGLTLCAECVLVGALHTAGGGRLVAFVCVTGTGAPVLPCGRCRQLLYEHGGPDLLVATAGGPRRLADLLPDAFGPADLPSADLPPPAARATSTGADTGRDAGAGQDDGDFR
>NC_015656.1|WP_013872485.1|1174432_1175716_+|thymidine-phosphorylase
MTFHVVDLIRTKRDGGRLPDAAVDWLISSYTAGAVPDEQMASYLMAVVWRGMRPAELSRWTAAMVASGERLDLSGLGRPTVDKHSTGGVGDKVSLVLVPLVVACGAAVPQLAGRGLGHTGGTLDKMAAIPGWRASLAPERMRSVLTDVGGVIAAAGAGLAPADRKLYALRDVTGTVESIPLIASSIMSKKIAEGTSALVLDVKVGSGAFMTAQAPARELAETMVALGDVAGVRTEALLTGMDTPLGRTAGNALEVDEAVAALRGGGPADLVEVTVALARRMLTLAGLAGGPDPADVLAAGRAHDVWQRMVTAQGGDPDAPLPVAPHVETLPAPATGFLRRLDARAVGLVAWRLGAGRARQDDEVSAVAGVRWFAGLGERVVAGAPLLELHTDDPARLATARAALADAVEIADTPPSVQRLVLDHVHL

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_015656_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015656_5

1556731-1556819

Orphan

Consensus_repeat	Method
GCCGGTTCGGACCGCCCGAGCAGGGAGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015656_5

>merge|NC_015656|5|1556731-1556819|CRISPRCasFinder
GCCGGTTCGGACCGCCCGAGCAGGGAGCATCACGGCGGAGAAGGACGAGCGTCAGGAGTGCGCCGGCTCGGACCGCCCGAGCAGGGAGC

>NC_015656|5|5|1556731-1556819|CRISPRCasFinder
GCCGGTTCGGACCGCCCGAGCAGGGAGC	ATCACGGCGGAGAAGGACGAGCGTCAGGAGTGC
GCCGGCTCGGACCGCCCGAGCAGGGAGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015656.1\|WP_013872776.1\|1546509_1547739_+\|glycosyltransferase-family-1-protein	unknown	unknown	gnl\|CDD\|340817
NC_015656.1\|WP_043605174.1\|1570336_1572400_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_015656.1\|WP_083828167.1\|1539040_1542337_+\|type-I-polyketide-synthase	unknown	unknown	gnl\|CDD\|238429
NC_015656.1\|WP_083828450.1\|1550470_1551040_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225408
NC_015656.1\|WP_043605171.1\|1565734_1566865_+\|DUF2993-domain-containing-protein	unknown	unknown	gnl\|CDD\|378597
NC_015656.1\|WP_131773884.1\|1537773_1539054_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|187656
NC_015656.1\|WP_013872786.1\|1561340_1563053_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223651
NC_015656.1\|WP_013872781.1\|1553315_1554242_-\|acyl-ACP-desaturase	unknown	unknown	gnl\|CDD\|153109
NC_015656.1\|WP_013872785.1\|1559982_1561140_+\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|132247
NC_015656.1\|WP_050803364.1\|1548646_1550374_+\|phosphomethylpyrimidine-synthase-ThiC	unknown	unknown	gnl\|CDD\|236451
NC_015656.1\|WP_013872784.1\|1558802_1559972_+\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173841
NC_015656.1\|WP_043603113.1\|1563070_1564801_+\|FAD-binding-protein	unknown	unknown	gnl\|CDD\|223354
NC_015656.1\|WP_013872790.1\|1567582_1570030_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224054
NC_015656.1\|WP_013872780.1\|1551641_1552661_-\|decarboxylating-6-phosphogluconate-dehydrogenase	unknown	unknown	gnl\|CDD\|236582
NC_015656.1\|WP_013872782.1\|1554499_1555813_-\|hypothetical-protein	unknown	unknown	unknown
NC_015656.1\|WP_131772283.1\|1572766_1573876_+\|hypothetical-protein	unknown	unknown	unknown
NC_015656.1\|WP_013872774.1\|1544963_1545449_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|180033
NC_015656.1\|WP_083828168.1\|1542792_1544967_+\|polyketide-synthase-dehydratase-domain-containing-protein	unknown	unknown	gnl\|CDD\|379688
NC_015656.1\|WP_013872793.1\|1573975_1575025_-\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274646
NC_015656.1\|WP_013872788.1\|1564953_1565685_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|187631

Protein	Function_ID	Function_description	E-value
NC_015656.1\|WP_013872776.1\|1546509_1547739_+\|glycosyltransferase-family-1-protein	gnl\|CDD\|340817	cd03784, GT1_Gtf-like, UDP-glycosyltransferases and similar proteins. This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the oxidatively cross-linked heptapeptide core of vancomycin group antibiotics. The core structure is important for the bioactivity of the antibiotics.	1.22168e-41
NC_015656.1\|WP_043605174.1\|1570336_1572400_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.10936e-81
NC_015656.1\|WP_083828167.1\|1539040_1542337_+\|type-I-polyketide-synthase	gnl\|CDD\|238429	cd00833, PKS, polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or more large multifunctional proteins and iterative type II PKSs, complexes of several monofunctional subunits.	5.33766e-148
NC_015656.1\|WP_083828450.1\|1550470_1551040_-\|hypothetical-protein	gnl\|CDD\|225408	COG2852, COG2852, Very-short-patch-repair endonuclease [Replication, recombination, and repair].	0.000139429
NC_015656.1\|WP_043605171.1\|1565734_1566865_+\|DUF2993-domain-containing-protein	gnl\|CDD\|378597	pfam11209, DUF2993, Protein of unknown function (DUF2993). This family of proteins with unknown function appears to be restricted to Cyanobacteria.	3.86157e-25
NC_015656.1\|WP_131773884.1\|1537773_1539054_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|187656	cd08953, KR_2_SDR_x, ketoreductase (KR), subgroup 2, complex (x) SDRs. Ketoreductase, a module of the multidomain polyketide synthase (PKS), has 2 subdomains, each corresponding to a SDR family monomer. The C-terminal subdomain catalyzes the NADPH-dependent reduction of the beta-carbonyl of a polyketide to a hydroxyl group, a step in the biosynthesis of polyketides, such as erythromycin. The N-terminal subdomain, an interdomain linker, is a truncated Rossmann fold which acts to stabilizes the catalytic subdomain. Unlike typical SDRs, the isolated domain does not oligomerize but is composed of 2 subdomains, each resembling an SDR monomer. The active site resembles that of typical SDRs, except that the usual positions of the catalytic Asn and Tyr are swapped, so that the canonical YXXXK motif changes to YXXXN. Modular PKSs are multifunctional structures in which the makeup recapitulates that found in (and may have evolved from) FAS. Polyketide synthesis also proceeds via the addition of 2-carbon units as in fatty acid synthesis. The complex SDR NADP-binding motif, GGXGXXG, is often present, but is not strictly conserved in each instance of the module. This subfamily includes both KR domains of the Bacillus subtilis Pks J,-L, and PksM, and all three KR domains of PksN, components of the megacomplex bacillaene synthase, which synthesizes the antibiotic bacillaene. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type KRs have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	5.03574e-49
NC_015656.1\|WP_013872786.1\|1561340_1563053_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|223651	COG0578, GlpA, Glycerol-3-phosphate dehydrogenase [Energy production and conversion].	6.54057e-126
NC_015656.1\|WP_013872781.1\|1553315_1554242_-\|acyl-ACP-desaturase	gnl\|CDD\|153109	cd01050, Acyl_ACP_Desat, Acyl ACP desaturase, ferritin-like diiron-binding domain. Acyl-Acyl Carrier Protein Desaturase (Acyl_ACP_Desat) is a mu-oxo-bridged diiron-carboxylate enzyme, which belongs to a broad superfamily of ferritin-like proteins and catalyzes the NADPH and O2-dependent formation of a cis-double bond in acyl-ACPs. Acyl-ACP desaturases are found in higher plants and a few bacterial species (Mycobacterium tuberculosis, M. leprae, M. avium and Streptomyces avermitilis, S. coelicolor). In plants, Acyl-ACP desaturase is a plastid-localized, covalently ACP linked, soluble desaturase that introduces the first double bound into saturated fatty acids, resulting in the corresponding monounsaturated fatty acid. Members of this class of soluble desaturases are specific for a particular substrate chain length and introduce the double bond between specific carbon atoms. For example, delta 9 stearoyl-ACP is specific for stearic acid and introduces a double bond between carbon 9 and 10 to yield oleic acid in the ACP-bound form. The enzymatic reaction requires molecular oxygen, NAD(P)H, NAD(P)H ferredoxin oxido-reductase and ferredoxin. The enzyme is active in the homodimeric form; the monomer consists mainly of alpha-helices with the catalytic diiron center buried within a four-helix bundle. Integral membrane fatty acid desaturases that introduce double bonds into fatty acid chains, acyl-CoA desaturases of animals, yeasts, and fungi, and acyl-lipid desaturases of cyanobacteria and higher plants, are distinct from soluble acyl-ACP desaturases, lack diiron centers, and are not included in this CD.	1.65101e-120
NC_015656.1\|WP_013872785.1\|1559982_1561140_+\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|132247	TIGR03203, pimD_small, pimeloyl-CoA dehydrogenase, small subunit. Members of this protein family are the PimD proteins of species such as Rhodopseudomonas palustris, Bradyrhizobium japonicum. The pimFABCDE operon encodes proteins for the metabolism of straight chain dicarboxylates of seven to fourteen carbons. Especially relevant is pimeloyl-CoA, basis of the gene symbol, as it is a catabolite of benzoyl-CoA degradation, which occurs in Rhodopseudomonas palustris.	2.05286e-49
NC_015656.1\|WP_050803364.1\|1548646_1550374_+\|phosphomethylpyrimidine-synthase-ThiC	gnl\|CDD\|236451	PRK09284, PRK09284, thiamine biosynthesis protein ThiC; Provisional.	0
NC_015656.1\|WP_013872784.1\|1558802_1559972_+\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173841	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26. Putative acyl-CoA dehydrogenases (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	3.54155e-130
NC_015656.1\|WP_043603113.1\|1563070_1564801_+\|FAD-binding-protein	gnl\|CDD\|223354	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion].	2.45026e-55
NC_015656.1\|WP_013872790.1\|1567582_1570030_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	2.16383e-61
NC_015656.1\|WP_013872780.1\|1551641_1552661_-\|decarboxylating-6-phosphogluconate-dehydrogenase	gnl\|CDD\|236582	PRK09599, PRK09599, NADP-dependent phosphogluconate dehydrogenase.	0
NC_015656.1\|WP_013872774.1\|1544963_1545449_+\|hypothetical-protein	gnl\|CDD\|180033	PRK05350, PRK05350, acyl carrier protein; Provisional.	0.00061388
NC_015656.1\|WP_083828168.1\|1542792_1544967_+\|polyketide-synthase-dehydratase-domain-containing-protein	gnl\|CDD\|379688	pfam14765, PS-DH, Polyketide synthase dehydratase. This is the dehydratase domain of polyketide synthases. Structural analysis shows these DH domains are double hotdogs in which the active site contains a histidine from the N-terminal hotdog and an aspartate from the C-terminal hotdog. Studies have uncovered that a substrate tunnel formed between the DH domains may be essential for loading substrates and unloading products.	7.55398e-22
NC_015656.1\|WP_013872793.1\|1573975_1575025_-\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|274646	TIGR03558, oxido_grp_1, luciferase family oxidoreductase, group 1. The Pfam domain family pfam00296 is named for luciferase-like monooxygenases, but the family also contains several coenzyme F420-dependent enzymes. This protein family represents a well-resolved clade within family pfam00296 and shows no restriction to coenzyme F420-positive species, unlike some other clades within pfam00296. [Unknown function, Enzymes of unknown specificity].	8.25955e-172
NC_015656.1\|WP_013872788.1\|1564953_1565685_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|187631	cd05373, SDR_c10, classical (c) SDR, subgroup 10. This subgroup resembles the classical SDRs, but has an incomplete match to the canonical glycine rich NAD-binding motif and lacks the typical active site tetrad (instead of the critical active site Tyr, it has Phe, but contains the nearby Lys). SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	3.88815e-21

>NC_015656.1|WP_013872782.1|1554499_1555813_-|hypothetical-protein
MTTQAHPGWDPGGLRRRPETAGRTRNPVDARNTAGHPDTAGHRQPDHRPVSQQPAGQPVHEQIAPANTGLDLLWTHDGLTRELMAMTRARRPHRFLPVSGPSLDSAAQRWLAARTHHEGVVPTGQLVDDPLVCGFEDRVDALRRMSDVLGGNDVYALSRTELSITVRLLRVGTHSDAHQARLYAVAAELARLAGWAMYDIGQYGTAQRCWLIALRAAHEANAPALGANILRCMAEQVTWYGQPADAVSLLHRAQAGARYLLSAIERAVIAADLAVAHSRAGSSEDAAAETELAYTLIDKVRPEDSPPYMYWARRKDVAFSAGEALLSSGSPEAAIPHFEAALDDLDELDEEVPRDRVEFLTRLGIANIRTGDADRAVALGHQAVSCATMIDSGMTRRDIARLCQELEQAGATAQTAGLVDHVRDALGPAGLSSPTLS
>NC_015656.1|WP_013872781.1|1553315_1554242_-|acyl-ACP-desaturase
MTSTPDINLLHELEPVAAANLNRHLDLATEWMPHEYVPWSQGRDFDTLPWDPEQSRLSDVAQIAFEVNLLTEDNLPSYHREIATIFGRDSAWGAWVHRWTAEEGRHSIVMRDYLMVTRGVDPVGLERGRMHQMQKGFDSGDKTPLRTIAYVSFQELATRISHRNTGRFTQDPIAEKLLTRVAADENLHMIFYRNLVAAALELTPSATVQAIAEELMTFQMPGTGIENFETKAKQIAKAGIYNLRNHHDDVVTPLLRHWKFFELTGLDAPAEQARENVGHYLTALDGLARRYEEKYAAAGQGTLAATSA
>NC_015656.1|WP_013872780.1|1551641_1552661_-|decarboxylating-6-phosphogluconate-dehydrogenase
MQLGMIGLGRMGANLVRRLIRHGHDCVVYDVNADAIRQLEAEGATGATTLAEFAAKLSTPRAAWVMVPAGITGQSVFALAEHFTAGDIIIDGGNSYYRDDVDRAKELTGRGIHYVDVGTSGGVFGLERGFCLMIGGENEVVSHLDPIFAAIAPGFDQAPRTPGRVGEPSRAEKGYLHCGPNGAGHFVKMVHNGIEYGMMAAFAEGMAILEKAGIGRDHTGEHDAETTPLAHPEYYQYDIDTAAVTEVWRRGSVVSSWLLDLTAAALVEDPKLESFSGRVSDSGEGRWTVLAAVEEGVPAHVLTASLYERFSSRGEALFADKLLSAMRKQFGGHAEKPAT
>NC_015656.1|WP_083828450.1|1550470_1551040_-|hypothetical-protein
MAESQDGVISVRTALRAGMTETEIRWKLRSGRWQRPMRGVLVTHSGPITDVQMMRAAVERRGPLRRNTLITDTLSDLGDGAHSVAEILYRKIENRYGLPAARRQERIDAGGSRYHLDVWYETWRVWVEIDGGYHREVRQWWDDLARQNAGVLQDRLILRFPVHVLRTEPRLVAEQVATALRQRGWEPNL
>NC_015656.1|WP_050803364.1|1548646_1550374_+|phosphomethylpyrimidine-synthase-ThiC
MSTPGGSPAPVTSGPLPGSRKTYLVGSADGLRVPMREVLLSTGDSVILYDTSGPYTDTEQVTDVRQGLPPLRDAWITARGDTETYQNASPQVRHGERLRRPSPRRALPGRAVTQLAYARRGEITPEMEFVALREGLPVETVRAEIAAGRAVLPANVNHPESEPMAIGSALLVKINANIGNSAVTSSIEEEVDKMVWATRWGADTVMDLSTGRDIHTTREWIIRNSPVPIGTVPIYQALEKVGGKAEELSWEVYRDTVIEQCEQGVDYMTVHAGVLLRYVPLTARRKTGIVSRGGSILAAWCLAHHQENFLYTHFAELCEILRAYDVTFSLGDGLRPGSIADANDAAQLAELATLGELTSVAWEHDVQVMIEGPGHVPMNKIKENVDLQRELCHDAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWYGTAMLCYVTPKEHLGLPDRDDVKAGVIAYKIAAHAADLAKGHPGAQAWDDALSDARFDFRWTDQFHLALDPETAKAFHDETLPAAPAKSAHFCSMCGPHFCSMRITQDVRKYAEEHGIAETDAVEAGLREKSAEFAARGSHVYLPIAES
>NC_015656.1|WP_013872776.1|1546509_1547739_+|glycosyltransferase-family-1-protein
MSRFLFVVPPLTGHVNPAVGIAGELAGRGHKVAVAGHPDVVGPLLTPGLTLLPFAGTFTGPSRAAVEERSRQLRGAASLKFLWEDFLIPLAASMVVDQQAVGAALVARRRALPWATLAATSAELDDPYELLPGVGRWVRDTLRDFQRSQGVSEDKARVGDLRFSEHLTLVCSVPRMLRTDSFPSYYGFVGIPLGRRPAVAFPWEWLDPEREHVLVSLGTVTREAGGRFLRVAVDALRPLGHRLQAIVVAPPGILGPPRVNPAPDGAAVADGAPADGAPVGAAQVGVSRGGGAEEHILVLPHVPQLDLMPRLSAVVSHGGNNTVCEALAHGVPLVVAPVRDDQPVIGEQVVRTGAGLRVRFGRVSAPALRESIVSVLDEPSFRVAARRLRGDFAAAGGAVAAADRLLAMI
>NC_015656.1|WP_013872774.1|1544963_1545449_+|hypothetical-protein
MTAKPLTTGHPTIGHPATSGPAVSGSAASGEAASGEAASGEAGSGAVEVTASGVERAAVEERILREVVALLHDVIGDEYVIDCEIDLSTSFNTDLELESIEFVALADRMRQHYGDTVDFVGFLADRNVDEVINMRVGEVVSFIADCLTPPQPSEPSQPPRS
>NC_015656.1|WP_083828168.1|1542792_1544967_+|polyketide-synthase-dehydratase-domain-containing-protein
MLAEFDALVAETNAMVSAVLAHWTASASAAGSGARGAGSGAPVARTSASAAGTSAAGSIAPTVRGGASDARARVSAAVQKAPAGPATAARTGHGGRPTPPAPAVPDAPAVPAGSSAGPPGRPAGAAGPAVPPGGRDVRQTRRTLSIETMPYIIDHCFYRQPPGWPHLADRFPVVPMTTVLEMMIGQARAAVPGRVVVGVTDVRALRWLAIEPAVEVTITTTVLPAVAGQDATGANASAVRVSIDGYAHGTVILADAFPPGPAPSAEPLPEPRDDTPLDGPSIYRAGRLFHGPGYQGLVTVGPVSPGGVHGELVVTSAPGPLLDAAGQLFGYWPREHLAADWLLLPSALRGVRFFGPHPAVGERLTCTVWIRDVRDSAVTADLEVRAADGTVWACVEGWTDRRFSQDELMWAMLLRPARNAIAERAAGGWVLAREHWADTASRELVTRYHLDTDERTILAAKHPRAAREWLLGRIAVKDAVRHWLWDSGVTDVWGIEIGVSDEDSGRPVIDRLPARAGVPATPPRVALAHTALLAVAVVHPDGAVGIDIERVTPLPAGVRAGTEMEAMALTDAERALLAELAGADAGLRALWLARFRAARQAAARADDTGQASWPRRFVVEGVTPGHLRVRTDDQEPSRARWVAHQSISALGEPLDDHGHPLGHTLGDPLGDRRSVAGSAAGRHSVDGPETGHYSVGGTDVDRYVVAWTSPEVEQAARENEGAWR
>NC_015656.1|WP_083828167.1|1539040_1542337_+|type-I-polyketide-synthase
MPGSRAGGPGGPPDPGAGIAIVGMAAVFPGAGDLDTYWRNILTGVDAIRDIPPQRFDPEFFHPDPGPGSGSGPDLGPDLGSGPDPGSDGGSEAAGERIRCRRGGFIEEFATFDPTQFGIMPLAVDWAEPDQLMALRVAAEAIADAGGVDALGDRGRTGVVLGRGGYFASGMARLDQRIKVSTQLVTSLSELVPTLTAEQLAGVHAAFTETLGPRRPEAAIGLVPNLAASRIANRLDLRGPAYTLDAACASSLIAVETAVRELVAGRADTMIVGGVHLAQEVTFWSVFSLLRALSPSSRIRPFDRRADGILIGEGVGMVVLRRLADAERAGDRIYAVIRGCGSASDGRTSTLLAPASDGQVLAVERAWADAGLDPRAPGALGLVEAHGTATPAGDAAELATLRQVFGADAGAGAGAWGGARPIGVGSVKSMIGHTMPAAGAAGLIKAALALHHRVLPPTLHCEQPHPAFAGTRLRPVAEAEAWDVDDGVPRRAGVNAFGFGGINAHVVVEEAPAPSNAPSLAFPATVPVPVPVMLPVPPPGAAAAAPLAVTTAAVPPGAGALPATVPLPVLAPVAAAPTTGPSTRSGERPGGERVLLFAGTSPAEIARALAVPDQELLARDDTAAPPEGGPYRLAIVAPDRRRLALARTVVERGRPWRGRNDLWFTGSPLLGATAAPDRTAFLFCGLEDNFHPRVDDVSAHFALTRPRHLSAGNLGPAAAGTGGWGEALGEHGVASVEVGRVLDTALRRLEIFPDLVGGHSIGEWNAMISAGMIDDEDVDRFIASFEPYSLEVPGVAFGALGCGADMAAATIADLPDVVVSHDNCPHQSIVCGEERSVETALQRLRGQGVLGRILPFRSGFHSPFLSPFLAKVRADVASIPIRTPTVPVWSATTVAPYPDDQNGIRELTVRHLLEPVRFRQLVERLYAEGVRVFVQVGVGSIAGFVQDTLPGREHLTVVTNTPKRPGMDQLRRVVAAFWVEGATPRMDRLSAMSTPATIPLPIPGPQRPSSSPSSPVPSPLSPLSSPLSPSAAYGGQEEAVDDGQRSSQQTHRGQPMLLNLGPHWFASASGRRRCCPRPCSRAQPRSHPRPWIRTRTRL
>NC_015656.1|WP_131773884.1|1537773_1539054_+|SDR-family-NAD(P)-dependent-oxidoreductase
MAGFTRTLAREVPDVVVRAVDLDPKEAPTRLAGYLLTEFLTPDAPSVTGYRHGVRSTLRVVPAEIPGAGAPPAASVAPVGPAGPVSLAALTLPAAGPSWGWRWHDDVASVPPPQAAGVLGELGPSSVVLLTGGARGITAKVALGLAQATGCGIELIGRTPLPAAAEDPATASAVDAPQLRRALIAAGLRRLTEVEARVTHLLAEREVRATVAALRASASFVRYHAVDVRDPDALRAVVETIYADRGRLDGVVHGAGVREDKLLREKTARSFERVFSTKVDAARTLVDALRPDLGFLVLFGSVSGVFGNRGQIDYAAANDALDTCAHAWARRLRGRVVSLDWGPWASPGSAGLAGGDREAAVAVAAGAGAGGGMVSAELARAYARRAIGLIDPDAGVAAVLRELAADVDDPQVVYLSGSLDAFDAGI
>NC_015656.1|WP_013872784.1|1558802_1559972_+|acyl-CoA-dehydrogenase-family-protein
MDLSFTPDEERFRAQLRAWLADNVPPRWRSPSFWAGVPEADAFELRRNWERLRHSAGFAGISLPREYGGRGGTPGMQAIHDEESARARVPHSVNQIGLTFLVPTVMAVGTDEQKREIIPLLLRNDVIWCQGFSEPGAGSDLAALRTTGVLDGDEFVVTGQKVWTTNAAHGDKIFMLVRTEPGSQRHHGLSMLLVDMRQDGVEARPLRQMSGVSEFGEVFFTDARVKVTDCLGGVGNGWATAMLLLSFERGASGLAQYTAFRRQFDEIVAAAPPGRLDDPVLRQRLAQRIVDLECLRYHAMHVLTQVEQGEELGAGSSLTKLQWSQTHQQLWETFDDLLGPEATLARPDPDTDLRAMHREAMWSRSVTIWGGSSQVQRNIVAERVLGLPR
>NC_015656.1|WP_013872785.1|1559982_1561140_+|acyl-CoA-dehydrogenase-family-protein
MYFALTEEQRALGDTVRDYLADRFDLTAVRAVFEDTGGDGHPAELWKTAGEQGWLAVLVPPEHDGLGLGLVDAQVVARAFGAGVVPGPWLPTVLAGEAIRLAGSPEQRRALLPRIATGDLVATVALRGPAGRYDPTGVRVTADAAGRLTGTALPVEYAEVARTVVVAATEPSGQTGLYLVDPRSPGVTVDGLDSYDGTVRAASLTLDGVDARRLPESSAAVLTELLDRAALLTAADLVGLARQALGRTVAYDRDRVQFGRPVGSFQALKHHLADLHLAVTMAEHAVLYAAHALDTGLADRRLAAAVAKSKAGDAAREVTGTMIQYHGGIGYTWEHEAHFFYKRAKREIYSYGDPDHHRERIASLTIGTSARPAPAPPVASPEPTS
>NC_015656.1|WP_013872786.1|1561340_1563053_-|FAD-dependent-oxidoreductase
MSSQRHRDNHHDTLDAPPRRRSAAGRTATPSRLPPPSHQATASHQATAPRRPTARPASSTASLNRRQRERDLAELADGAVVDVLVIGGGVTGAGVALDAASRGLSVALVEAHDLAFGTSRWSSKLVHGGLRYLASGDLALAHESARERAVLLGTTAPHLVRPLPMLLPLAAGFPISTALAANAGLRVADILRRAAGTPRTVLPGPRRLTAVEARHMVPALRAPGLRGGLLTWDGQLVDDARLVVAIARTAARHGTRVITRCRVREADGSGATAVDTVSNSPVILRSRSVVNATGVWAGDLCADARLRPSRGTHLVVAGSALDGLRTAIIIPVPGERNRYVFALPQPGGHVYVGITDEPVDTVVDVPVPTAAELDFLLGVLSSVLTVPVGRADVLGAFAGLRPLLASAAGRTADLSRRHAVITSSDGMVTVVGGKLTTYRRMAADAVDTLVRAGGLDAGPCRTRRLPLVGAASWSQLATVDAPPRLVARYGAEAPAVVAGTHGDPGLLLPLCDGVEVTGAELLFALRHEGALDADDLLDRRTRIGLVPADRQAALPAAEALVRQTLTMIDT
>NC_015656.1|WP_043603113.1|1563070_1564801_+|FAD-binding-protein
MTASTTNRSGTVWWGWGAPDAHTPLAEDIRSLLEAAFAVARQDTPPVGLDELHLPASSLSVEASEALAGVVGPAWVRVDAGSRVRRCRGRSTADLLRLRAGDALDAPDAVVLPAGHDEVLAVLRVCARLRLAVVPFGGGTSVVGGLAPARGGFAGVVALDLARLDRLTAVDAESQVVTCEPGLRGPALEAALAAHGFTLGHRPQSWEYASVGGFAATRSSGQASAGYGRFDSLVVGLRIATPAGTWELGRAPASAAGPDLRQLALGSEGAFGVITQLRLRVRPLPAATHYEGWRLAGFAAGTAALRELAQRDLLPTVARLSDETETAAGLAGGGIGADAGGCRLIAGYEGEADWVAARQAAVAEVLGAAGGVPLGAEAGTQWVRGRFHGPYLRDALLDAGMFAETLETAGFWSALPGLYTRVRDTLVAALTAEQAAGQTVRQAAGPPAGATAGPAGEAAAGPAGAGAGEAAAGGAPGLVMCHVSHVYPTGASLYFTVVCPGRDDPVARWRRVKAAASRAIVETGGTITHHHAVGVDHQPWLTAEIGDLGVAVLRAVKHTLDPDGILNPGVLVPRAT
>NC_015656.1|WP_013872788.1|1564953_1565685_+|SDR-family-NAD(P)-dependent-oxidoreductase
MQQERADPRRERALVIVGPGQAFGVQLLRRFAREGFGLGVIARSADTVHRVTADLARDQITVSGEVADVTAPGAVATALDKLADELGGLTAVVYNAKLSIRGTALSVSADTVNQTLAVNVTGALTVVQAAVALLAERPGACVLLTAAGPRTEPAAGRFALAIGKAGLLALGTSLAPVLRTRGIRLRTVVLDARVAPDGRLSPDVVAEHFWNAYTAARGSVFRLGPPSVTERAPHLFGDGHFPG
>NC_015656.1|WP_043605171.1|1565734_1566865_+|DUF2993-domain-containing-protein
MSTGHDNDPDVGSDPEESTRRLPPSAAAAGAGAQTQRARVGPVSPPPPADSFRPAAQPGWPGPDAPPGSPAQPGTPAAPIPPTSALPPPEGSPYGSPPYTGAQYGGAQYGGPPYGGQPPLAPTDVTPGPVARRRRRRWPIITLVALIILLVVADRAAVPIAESQMKAKAEASVAQSSTDPGVRPARVTDVSIGGFPFLTQVLFGKYDDLRVTVTDIPTPGPRITEVKARLQGVHVPFWDAIRDQVKDVPVDKVTADVQITYDDLNAYLATQDVKITPVDDGREVRISGEIDTGILGTQELSGTTRFGVQDNTLTLIPTEILGFRLPGVALPGIPLPISNLPFNLQIEKAATGKNGISVTATATNVVLPAAEPTSAS
>NC_015656.1|WP_013872790.1|1567582_1570030_+|ATP-binding-cassette-domain-containing-protein
MQTTLRVVSGANVATVPAGQPFVVGRARTADFVMPDSRVSRRHLLIEPVGAGWAVRDISSNGTWLDGQRVQSVDVNGEVRFRLGTPTGPEVVVLLEVPVGYADPPRYQDSHFEMPTMLRGSVSYEPGPQLPRQPAGNQAETSSHDLEREHERQTSYRLRPGRMSIGRSRDNDIVVGDLLASRQHAEIYLGPGGDVEIADLESANGTFVNGKRIIREPVPQGAVIAVGHHVFQRVEDELVEYVDSGDVSFEADGLNVWAGQKQLMHDMTFRLPGRALLAVVGPSGAGKSTLLNALTGFRPADKGTVRYAGRDMYSEYDELRRRIGYVPQEDLLHTTLSVRRALEYGAELRFPPDTTKQERGARVDEVLAELGLTQHADTQVSRLSGGQRKRTSVALELLTKPTLLYLDEPTSGLDPGMDKNVMESLRKLADDGRTVVVVTHSVAQLDLCDYVLVLAPGGYVAYFGPPRDALSFFNKRDYPDVFLMLEATPGAESADRFRQSRYYVPASITAPSARPAPEDLPSIRQQSVLSQLVTLSRRTLSVVASDRSYLRLIIAFPFLLGLIPRAIPGGFGLPEDGSPNSDAGTILLVMVLCACFMGMANSVREIVKERAIYRRERAIGLSRTAYIGSKILVLALITTLQAIPFTLIGLLGREPDEALVLGNPLVECLLAVIVVSLSSAMLGLLISALVDNADKTMPLLVLLTMAQLVFSGGILPVHSKPGLEQVSLIAPARWGYAALSSVGDLNRISLAGQLRPDGKLLNSKVVDDPFFDHTAQAYAVDIAGGVAIGVICVIITAILIRRMDPKTAKRKPSSS
>NC_015656.1|WP_043605174.1|1570336_1572400_-|serine/threonine-protein-kinase
MTPPDAATDVQTTALGPDDPVQLGSYTLLGKLGEGGMGTVYLGRSETGRLVAIKVIRADVAGDAEFRSRFRLEAETARRVARVCTAEVLDAAPDAARPYLVTEFIEGRTLARFVTESGPLSAANLEQLAVGVAAALTAIHSAGIVHRDLKPSNVVLSPFGPRVIDFGIARALDSASNLTGNLQQLGTPAFMAPEQIQGETITPAVDIFSWGGLVTFAATGRYPFGDASAQVLLYRAVNEAPRLDGLDPPLREIVADAMAKSPSARPTAQQLMLRLLGEPSSVAEIDPEATVIQVLDGWKLPTADGTGSTGGAGGDGTTVAAGREQRPAATVRGSGRAPRSARRMALVAAGAAVAVLATVGGVLALASGGSGADGEGVKVVDILPKSDVGLDDDTLVYSSEQEGRRAIYSLRVGPDGRPGQPQRLTVDDTKPAALPVIVGPQRKTVLYTVIDSSPSLVAIAADGSGAPMPLFTSGPAAELVIAPDARASVDPTGRFVVIRAVRGPNDGLTGLYVAAVDGSSVRRLNVPAGATDPSWSPTGDRIVFFVGSGGVDGGALFTIDADPAAAGAKPVQLTPGTEGFDADPTWSPDGKKVAFRRAFDPNLAETDVFVMDASPGATPLRLTEAPGRDQDPTFVAGDGKLIAFTSQRDGPTNREIYVTSATAPDDANARKLTSFRGDDATPRWTSG
>NC_015656.1|WP_131772283.1|1572766_1573876_+|hypothetical-protein
MPTADPTTPVWGFLRSDEAAPTIGAPRTPAAEVQAGSWQSAADTRQAKATVIRRGTGRYSAIFPGIGVPAGRGAAVVTAVGDAPVHCHAEDWAPSGPDEQVTLACRSLTGAYVDSRFTALFTFAPASHRPTPSEPYAYFRDDAPSQQQIRPDNSYSFAGPGTIEINWRGIGHYSIDLIGKLYARTGNNLQVNSVGSTTVGCSALGREVHEDRQTIFVGCANGQTWTDSPFVVVYGNQHTVIPVENAAFGHSFTGLEEAGTGRILQPPLGRTVDVWPRYSANSAKRTNTIRHVETGVYEIAYPGVGRAPEHVQVTPYGEPTRRCAIAEWTSPPTGAVGDVRTKVVCFDPDGSRADSQFSLAYVSAAGLTP
>NC_015656.1|WP_013872793.1|1573975_1575025_-|LLM-class-flavin-dependent-oxidoreductase
MALSRSLPLSVLDVVPVVSGSTPAQAVRNTLDLARRAEELNYHRYWLAEHHSMPGIASSATSILIGQVGAATTSIRVGSGGIMLPNHAPLIIAEQFGTLGALFPGRVDLGIGRAPGTDSATAQALRRSSGPVSADDFPAQLAELVAFLGNSFPASHPLRTVTAVPHGETPPVWLLGSSGYSAQLAGYLGLPFAFAHHFSAVNTLPALALYRSAFRPAPGREQPYAMVAAAVICADTDETAQWLAGPTQLTMLRLRQGRPDVFPTPEQAAAYPWTPAERAAADGAAASHIVGSPDTVRASLDALIDATEADEIMIVTNVHPHDARIRSYELIAEFAGLPGLPAPREPLSA

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_015656_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015656_6

2008918-2009004

Orphan

Consensus_repeat	Method
TGTCGCGTGCTCGGAGGCCGCTTCCCAGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015656_6

>merge|NC_015656|6|2008918-2009004|CRISPRCasFinder
TGTCGCGTGCTCGGAGGCCGCTTCCCAGTACTCCGGCCGAAGGGTATGCGATCATGCCTGTCGCGTGCTCGGAGGCCGCTTCCCAGT

>NC_015656|6|6|2008918-2009004|CRISPRCasFinder
TGTCGCGTGCTCGGAGGCCGCTTCCCAGT	ACTCCGGCCGAAGGGTATGCGATCATGCC
TGTCGCGTGCTCGGAGGCCGCTTCCCAGT

Protein	Signature genes	Signature genes Name	Protein_function
NC_015656.1\|WP_013873102.1\|1998941_1999574_-\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|240039
NC_015656.1\|WP_083828459.1\|2015317_2016304_+\|protoheme-IX-farnesyltransferase	unknown	unknown	gnl\|CDD\|235293
NC_015656.1\|WP_013873107.1\|2006757_2006988_+\|preprotein-translocase-subunit-SecG	unknown	unknown	gnl\|CDD\|235881
NC_015656.1\|WP_013873115.1\|2016617_2017670_-\|heme-A-synthase	unknown	unknown	gnl\|CDD\|224528
NC_015656.1\|WP_013873117.1\|2018582_2019524_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NC_015656.1\|WP_131772376.1\|1997797_1999036_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340840
NC_015656.1\|WP_013873111.1\|2010632_2011784_-\|glucose-6-phosphate-dehydrogenase-assembly-protein-OpcA	unknown	unknown	gnl\|CDD\|378404
NC_015656.1\|WP_131772378.1\|2004614_2006387_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173871
NC_015656.1\|WP_013873100.1\|1997399_1997621_+\|hypothetical-protein	unknown	unknown	unknown
NC_015656.1\|WP_013873105.1\|2003589_2004417_+\|triose-phosphate-isomerase	unknown	unknown	gnl\|CDD\|234589
NC_015656.1\|WP_131773919.1\|1996542_1996935_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237871
NC_015656.1\|WP_013873103.1\|2001087_2002095_+\|type-I-glyceraldehyde-3-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|223135
NC_015656.1\|WP_013873116.1\|2017737_2018586_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|272861
NC_015656.1\|WP_013873108.1\|2007008_2008763_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173871
NC_015656.1\|WP_013873104.1\|2002322_2003588_+\|phosphoglycerate-kinase	unknown	unknown	gnl\|CDD\|234613
NC_015656.1\|WP_013873112.1\|2011780_2013313_-\|glucose-6-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|235579
NC_015656.1\|WP_013873118.1\|2019755_2020436_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|319351
NC_015656.1\|WP_013873110.1\|2009784_2010633_-\|6-phosphogluconolactonase	unknown	unknown	gnl\|CDD\|376480
NC_015656.1\|WP_013873113.1\|2013452_2014583_-\|transaldolase	unknown	unknown	gnl\|CDD\|235117
NC_015656.1\|WP_013873109.1\|2009216_2009552_+\|RNA-polymerase-binding-protein-RbpA	unknown	unknown	gnl\|CDD\|379162

Protein	Function_ID	Function_description	E-value
NC_015656.1\|WP_013873102.1\|1998941_1999574_-\|NUDIX-domain-containing-protein	gnl\|CDD\|240039	cd04683, Nudix_Hydrolase_24, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	1.46661e-14
NC_015656.1\|WP_013873107.1\|2006757_2006988_+\|preprotein-translocase-subunit-SecG	gnl\|CDD\|235881	PRK06870, secG, preprotein translocase subunit SecG; Reviewed.	2.67841e-11
NC_015656.1\|WP_013873115.1\|2016617_2017670_-\|heme-A-synthase	gnl\|CDD\|224528	COG1612, CtaA, Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones].	3.14538e-34
NC_015656.1\|WP_013873117.1\|2018582_2019524_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	2.18031e-87
NC_015656.1\|WP_131772376.1\|1997797_1999036_+\|glycosyltransferase	gnl\|CDD\|340840	cd03812, GT4_CapH-like, capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1).	1.74095e-44
NC_015656.1\|WP_013873111.1\|2010632_2011784_-\|glucose-6-phosphate-dehydrogenase-assembly-protein-OpcA	gnl\|CDD\|378404	pfam10128, OpcA_G6PD_assem, Glucose-6-phosphate dehydrogenase subunit. Members of this family are found in various prokaryotic OpcA and glucose-6-phosphate dehydrogenase proteins. The exact function of the domain is, as yet, unknown.	2.80595e-86
NC_015656.1\|WP_131772378.1\|2004614_2006387_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|173871	cd08506, PBP2_clavulanate_OppA2, The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold. Clavulanic acid (CA), a clinically important beta-lactamase inhibitor, is one of a family of clavams produced as secondary metabolites by fermentation of Streptomyces clavuligeru. The biosynthesis of CA proceeds via multiple steps from the precursors, glyceraldehyde-3-phosphate and arginine. CA possesses a characteristic (3R,5R) stereochemistry essential for reaction with penicillin-binding proteins and beta-lactamases. Two genes (oppA1 and oppA2) in the clavulanic acid gene cluster encode oligopeptide-binding proteins that are required for CA biosynthesis. OppA1/2 is involved in the binding and transport of peptides across the cell membrane of Streptomyces clavuligerus. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	2.336e-147
NC_015656.1\|WP_013873110.1\|2009784_2010633_-\|6-phosphogluconolactonase	gnl\|CDD\|376480	pfam01182, Glucosamine_iso, Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase.	7.23892e-73
NC_015656.1\|WP_013873105.1\|2003589_2004417_+\|triose-phosphate-isomerase	gnl\|CDD\|234589	PRK00042, tpiA, triosephosphate isomerase; Provisional.	7.07511e-136
NC_015656.1\|WP_131773919.1\|1996542_1996935_+\|hypothetical-protein	gnl\|CDD\|237871	PRK14965, PRK14965, DNA polymerase III subunits gamma and tau; Provisional.	0.00404083
NC_015656.1\|WP_013873103.1\|2001087_2002095_+\|type-I-glyceraldehyde-3-phosphate-dehydrogenase	gnl\|CDD\|223135	COG0057, GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism].	7.20296e-174
NC_015656.1\|WP_013873116.1\|2017737_2018586_-\|ABC-transporter-permease	gnl\|CDD\|272861	TIGR00025, Mtu_efflux, ABC transporter efflux protein, DrrB family. The seed members for this model are a paralogous family of Mycobacterium tuberculosis. Nearly all proteins scoring above the noise cutoff are from high-GC Gram-positive organisms. The members of this paralogous family of efflux proteins are all found in operons with ATP-binding chain partners. They are related to a putative daunorubicin resistance efflux protein of Streptomyces peucetius. This model represents a branch of a larger superfamily that also includes NodJ, a part of the NodIJ pair of nodulation-triggering signal efflux proteins. The members of this branch may all act in antibiotic resistance.	1.4033e-27
NC_015656.1\|WP_013873108.1\|2007008_2008763_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|173871	cd08506, PBP2_clavulanate_OppA2, The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold. Clavulanic acid (CA), a clinically important beta-lactamase inhibitor, is one of a family of clavams produced as secondary metabolites by fermentation of Streptomyces clavuligeru. The biosynthesis of CA proceeds via multiple steps from the precursors, glyceraldehyde-3-phosphate and arginine. CA possesses a characteristic (3R,5R) stereochemistry essential for reaction with penicillin-binding proteins and beta-lactamases. Two genes (oppA1 and oppA2) in the clavulanic acid gene cluster encode oligopeptide-binding proteins that are required for CA biosynthesis. OppA1/2 is involved in the binding and transport of peptides across the cell membrane of Streptomyces clavuligerus. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	3.02822e-101
NC_015656.1\|WP_013873104.1\|2002322_2003588_+\|phosphoglycerate-kinase	gnl\|CDD\|234613	PRK00073, pgk, phosphoglycerate kinase; Provisional.	0
NC_015656.1\|WP_013873112.1\|2011780_2013313_-\|glucose-6-phosphate-dehydrogenase	gnl\|CDD\|235579	PRK05722, PRK05722, glucose-6-phosphate 1-dehydrogenase; Validated.	0
NC_015656.1\|WP_013873118.1\|2019755_2020436_-\|transcriptional-regulator	gnl\|CDD\|319351	cd16837, BldD_C_like, C-terminal domain of BldD and similar transcription factors. The Streptomyces transcription factor BldD dimerizes via an unusual mechanism that inolves a tetrameric c-di-GMP assembly. BdlD is involved in controlling multicellular differentiation in sporulating actinomycetes.	3.54428e-16
NC_015656.1\|WP_083828459.1\|2015317_2016304_+\|protoheme-IX-farnesyltransferase	gnl\|CDD\|235293	PRK04375, PRK04375, protoheme IX farnesyltransferase; Provisional.	2.35897e-141
NC_015656.1\|WP_013873113.1\|2013452_2014583_-\|transaldolase	gnl\|CDD\|235117	PRK03343, PRK03343, transaldolase; Validated.	0
NC_015656.1\|WP_013873109.1\|2009216_2009552_+\|RNA-polymerase-binding-protein-RbpA	gnl\|CDD\|379162	pfam13397, RbpA, RNA polymerase-binding protein. RbpA is a family bacterial RNA polymerase-binding proteins. RbpA acts as a transcription factor by binding to the sigma subunit of RNA polymerase.	7.56818e-56

>NC_015656.1|WP_013873108.1|2007008_2008763_+|ABC-transporter-substrate-binding-protein
MPARLLCLVVLATVVACGGGGQPAPAPVTSITPTVTSDPTDKPGGTLRLVTGAMPSGDPGWATDAGSRMLLRLVSRQLYSYRASPDPVFTAAPLPDLAVGPPVVSEDGKTHTVTLRPSARWDTPGVRRVTATDVARGIKRLCTPPNPSPMRGYFAATVVGFATYCDELMKTPPEGVRDFIERRGIDGVQVIGDDSIEFHLLAPAADFTDVLALPAASPVPLEALVYAPNSPEYLENLISDGPYHFGNTLGDESYRLSRNPAWVASSDGIRPALADHVTVRTGVDAATAQAEIDADRADMAMDSTVPAADVTALDAQADGRLSTDGPGSTVLLTVGLHGPASAALGGGGVRQALVYCVDRAAVAAALGGPVLATTTAQMLQPAMTGFQSRDPFPTLGSTGDPARCREGTRTAADGGPLTTLVLLTTDSAEDAAVASALRDAFARAGVTLRVEAVPAADYPGVAVPSSTVGWDLALTRVTPQWFGNAGRSVFQPLLEPQWSGSRPADGGYRNDRIAQLLRDALGERDPAALSTRWGDLERELLTDAAIIPLAVTVTPRFHSANVRGFLRVPSLDAADPTAISLGIA
>NC_015656.1|WP_013873107.1|2006757_2006988_+|preprotein-translocase-subunit-SecG
MTVGLSIVLIITSVLLMLLVLLHRAKGGGLSSLFGGGVSSSLGGSSVVEKNLDRLTVMIGLIWLTCIIGLGLLLKE
>NC_015656.1|WP_131772378.1|2004614_2006387_+|ABC-transporter-substrate-binding-protein
MPRCRAIIRAGTVMVVLGLLLAACTGGGGRRQAPSDPSGPPTAISDRVIAASPRDGGTLRVLATVDCDSWDPQRTASLHCWNQQRWISRQLVTYAPSPGVVKLAGDLATEVPSSKDLRTWTYTLREGLAFEDGTPITSRDVKYGIERAFAPELAGGGSDASSGAGEVVRLLQDEKNPYRGPYTDPTPDRLGLASVTTPDEKTITFRLNRPFADWNLLMASPVSTPVPRAHDTGAGYGSRPVASGPYKIENYRPGESLTLARNPRWDRQTDPNRPAHPDRVVERMGLAAADIDSRILTDQADIAADQSGVGAEAAARISANPGLRAARTTSEATGGLRYLAVVTKVAPLDNLACRNAVAWAVDKSAQQTARGGPLVGGDIAATMLTPPVHSFSWFDLFPSPDGSGDLAKAKTELNSCGRPDGFATTLVTRSDPLSLAQAEAVRVALARVGITITVAKFDDAGYTAAVDSPDQVHTMKYGLVLAAGAATRPTPYAFLAPLAASGSIRPQHNTNVAELALPAVDQGLEQGIGTADSEDTASRWTQMDRAIVGSAAYVPLLYDRALNVYSSRLTNIHYSPGFMMTDFASLGVVP
>NC_015656.1|WP_013873105.1|2003589_2004417_+|triose-phosphate-isomerase
MAGDKNEKNKNEKKPRGTGRRTLVAGNWKMNLNHLEAIALVQKIAFDLKPVELDNAEVVVLPPFTDLRSVQTLVDGDRLAIGYGAQDLSPHSSGAHTGDISGPLLARLGCSYVVVGHSERRANHHEDDALVAAKARAAYAHGITPILCVGEPEPVRVAGDHATYVLAQLDGSLDGITLEQARTLVVAYEPVWAIGTGRTASAHDAQEMCAAIRGRLAARFDAGVAAVIRILYGGSVKGSNAAELFTQPDVDGGLVGGASLDAVDFAAIVRSAPPS
>NC_015656.1|WP_013873104.1|2002322_2003588_+|phosphoglycerate-kinase
MTTIDDLQVGGRRVIVRSDLNVPLDRSGDTPRITDDGRVRASVPTIRALLDRGARVVVSSHLGRPRGTPDPAYSLAPVAGRLAQLLGQPVAFTGDGTGDIAGTHAQKIVAGLGDGEIALLDNLRFHPGETSKDAAVRAAFADQLAGLADYYVGDAFGAVHRAHASVVDLPERLPHVAGQLVLRELEVLRTLASGPARPYVVVLGGSKVSDKLGVIRALLPKVDALLIGGGMCFTFLAAKGHGVGGSLLEAELIDTTKELLAEGGDRIVLPTDVVVADEISVDAPTAVVAAGAIPAGRKGLDIGPASVALFADRLRTARTVFWNGPMGVFELPPFAAGTRGVAETIAGLDGLTVVGGGDSAAAVRTLGIGEEAFTHISTGGGASLEYLEGKTLPGLAALDDRRPRDDVSFTRPEARLPGSEV
>NC_015656.1|WP_013873103.1|2001087_2002095_+|type-I-glyceraldehyde-3-phosphate-dehydrogenase
MVTRVGVNGFGRIGRNFWRALQASKRNDIEIVAVNDLTDNRTLAHLLKYDTTLGTLSESVSPADGGIKVGDGFLKVVSERDPAALPWGDLGVEVVVESTGRFTKAEDARKHLEAGAKKVIISAPAKGEDLTVVIGVNDDVYDPAKHTILSNASCTTNCVAPLAKVLEDAFGIERGLMTTVHAYTNDQVILDFPHSDLRRARAAAQNIIPTTTGAAKATSLVLPQLKGKLDGLAMRVPVLDGSVTDLVATLKREVTIEEVNAAYRAAAEGALKGILVYTEDPIVSSDIVGTAASCTFDSLLTMASGNQVKVIGWYDNEWGYSNRLVDLTALVGGRL
>NC_015656.1|WP_013873102.1|1998941_1999574_-|NUDIX-domain-containing-protein
MSGRTGYGHDDVPEHSPRKAHREMSRSALPVRVHLLVRTEDRILLATGDETSPACWRLPAGNLQGQAAGDAAVRLAREQAALLTTVEDVRLEHVAHHWADDREQLGLFFHVTRTYGATGAHDPAAPGVPRRPRRLAWHPLDALPERFAQPDHDVVTRWASGEFFSHGGWTARRSTTIRPSTGAVQAAPQTVSAQTVSTRPPSAPAASSRA
>NC_015656.1|WP_131772376.1|1997797_1999036_+|glycosyltransferase
MNRGGAQLRTVELMRRLDPNEFRLVFCSLSGRRGDLDDEIRSLGGEVYYRRLGPAFPLTFYLLLRRVRPQVVHAYASDATGLVFGIARMAGVPRRVAHFRVRDDGPGDTAGRPGGRTGRPAAGTGWAAAGTGWPGGSTHRRGRNAGALLRHEAGRVALDANATDLLAVCEAVMRELWRPEWRVDPRCRVIYNGLEVEPFGVAIAARRRALESVPEGTRTPVVMIHIGRPGANKNRARAMDILVALCARGVDARLQIVGRQDAAETADLLARASAGGVRDRVELLGERDDVPRLLVAASLLLVTSYHEGLPSVVLEACAVATPVLATDLPGIAEVARLLPGITMLPLSATDEIWADTARVLTAVPPLLEDRRAALRHFVRSPFTLENWQRELTAVWSRPSEPRPSEVLPERRR
>NC_015656.1|WP_013873100.1|1997399_1997621_+|hypothetical-protein
MGVVVATDVRLRRPPEGGVGMGGHAGVGGSVGVGGSVGLSGSATRDHDRWDILATGGCVGVGGSAAGEAVRRS
>NC_015656.1|WP_131773919.1|1996542_1996935_+|hypothetical-protein
MPMLVREAGRMFPGALPALDTWTAPWSSRPSARAPAADASTAGARADGADASRAARPAAGPVADLLVAHPATTDAVAALLSLAPAWPATATQGQPTPTGRGDDEISWDEIARLLDRHPATATAVTGLLEH
>NC_015656.1|WP_013873109.1|2009216_2009552_+|RNA-polymerase-binding-protein-RbpA
MAGGNAIRGSRVGAGPMGEAERGETAPRQRISFWCANNHETRPSFAADATIPETWDCPNCGFPAGRDRDNAPAPPKTEPYKTHLAYVRERRNEKDGEAILAEALAKLRGTA
>NC_015656.1|WP_013873110.1|2009784_2010633_-|6-phosphogluconolactonase
MSTSPEVIVHRDPELLATATAARLVISLLDAQATRGSASVVLTGGGIGVATLRAVRDSPLVETVDWSRVDVWWGDERFVPAGSADRNDRQARQALLDALPLDPARVFPMGSADAADGTGAATGTSAVTGTDAAESAATAYARLLAEYAPTGAAAAAGTVAVPSFDVLLLGVGPDGHVASLFPGSSAVHARTATVAVHHSPKPPPTRISLTLPTIQAAHEVWLLAAGEAKADAVARAFSGAAPADIPAVGARGRQRTLWLVDRAAAARPVSAGASPARRVSAG
>NC_015656.1|WP_013873111.1|2010632_2011784_-|glucose-6-phosphate-dehydrogenase-assembly-protein-OpcA
MTTLWDTTGTDVVRALAAERRSAGALAFGLALTLVVVVDEKHVSAAESAATTAAAAHPCRLLIIVRRQLDAPNSRLDAEVSIGGRLGPGEAVVMRMYGRLGLHAESVVLPLLAPDAPVVTWWDGEPPDRIAYDPLGVFADRRVSDAAAAPDPVAALRRRAVDFAPGDTDLAWTRLTGWRTLTAAAFDSITEQPRSVTIAGSPTDPSVCLLSGWLADRLHVPVTVSETVSRGGPTEIRVDFDHDDELTLARQDSHTALLRRPGRPDRALPLPERGLGDLLAEELRRLDDDEPYADALSAWSGIAGLASRPAVREHVWRDPMAPENTGATDNSGGGADGVDGADGNGAAGSAGGAGATATAGPADPAVTTTPGTNPAGNGARASG
>NC_015656.1|WP_013873112.1|2011780_2013313_-|glucose-6-phosphate-dehydrogenase
MTPTVRANPLRDPRDRRLPRLPDPCALVVFGVTGDLARKKLIPAVYDLANRGLLPPGFVLLGFARRDWDDDSFAEVLREAAQKGARTPFREEVWDRLASSVKFVQGSFNDDQAFDTLAKTLLDLEHSHGIPGNAAFYLSIPPSAFPVVLKQMQRTGMASNEASGGWRRVVVEKPFGHDQESARALNELVDDVFTAPDVFRIDHYLGKETVQNLLALRFANTLFEPIWNSHFVDSVQITMAEDVGIGTRAGFYDETGAARDVLQNHLLQLLALTAMEEPVSFNAEAIRYEKLKILRAVSLPDDLASYAVRGQYEQGWLAGQRVRGYLEEDGVPAGSRTETFAAVRLGIETRRWAGVPFYLRTGKRLPRRVTEIAISFKPAPHLPFDATDTSELGHNQLVVRVQPDEGVTLKFGSKVPGSAMEVRNVAMDFLFGEAFTESLPEAYERLILDVLLGDATLFPNNAEVIESWRVIDPMEDFWAGSAPHLYRAGTWGPAAADEMLARDGRCWRRP
>NC_015656.1|WP_013873113.1|2013452_2014583_-|transaldolase
MTDPLALLSAADVAVWLDDISRDRLRTGNLAELVRTRSVVGVTSNPTIFQKAISTGSAYDEQLRDLAVRGVDIGEAVRAITTADVRAACDVLRPAYEASGGVDGRVSIEVDPRLAHDTERTVAEARALWWLVDRPNLFIKIPATLAGLPAITATLAAGISVNVTLIFGLDRYDAVMDAFMTGIERAVAAGREPAGIVSVASFFVSRVDTEVDRRLEKIGTAEAKALRGKAAVANARLAYQRYEQAFATERWSALAKAGARPQRPLWASTSAKDPSLPDTIYVAELVAPGTVNTMPEATLHAFADHGVVRGDTIRPYYDDAHAVLAALADLGISFPDVVEVLEREGVEKFVDSWNQLLTAIGEQLATAGSRPEALAG
>NC_015656.1|WP_083828459.1|2015317_2016304_+|protoheme-IX-farnesyltransferase
MPAQPAAGGRGGPTGPTGPSGSPDPGEPGRSTRSRRPVGALARSYVALTKPRIIEQLLITTIPVMLLAEHGLPSPWLILATLVGGTFAAGSANTFNCYIDRDIDQVMARTRTRPLVRANVTPAEALRFGFLLGVAATLLFGFAVNWPSALLADAAIAFYVFVYTLGLKRRSPSNIVIGGAAGCFPVLIGWSAVTGTIGWPAVLLFAVIFFWTPPHFWALAIKYRDDYAAAGIPMLPVVASPTVVARRILGYSYVMVATSLLLVPVADTGWPYLVVAALLGGWFLVEAHRLVHSVRRGGQIRPMRLFHLSITYLTLLFAAVALAALWHP
>NC_015656.1|WP_013873115.1|2016617_2017670_-|heme-A-synthase
MRQPLRLPTVSPVVFQRLTRVSVVLLALIVVTGGAVRLTGSGLGCPTWPRCGEDSFVTQSEYSVHGWIEFGNRLLTTVVGAVMLLLPLVSLRLRERRRDLVLLAFGLWLGFLGQVVLGGLTVLFKLHPALVAGHFLLSMLLLLDVVALDRRARAGPGPARPAGGRELRWLSRLLVGVAGAVLVLGTVVTGTGPHSGDSAEAKRFGFDITNVAQLHADAAMLLVGLVIATVLTVRVGGASWEAVRASNALAVITVAQAGVGFVQYFTGVPVALVELHIAGATALWIAALHVWLAMVNRPAPVDLPASPPGPRRPPPTGHPADPTAGAPAADDPTSGDAAGTADQHRSKAPL
>NC_015656.1|WP_013873116.1|2017737_2018586_-|ABC-transporter-permease
MTDTEVPIGGRSGKPARPVGSGSAAGVRQPLDLRPAPGAARRWNMLRAQTTIELKLTLRRGESLLLTLVIPVGLLLFFTAVDVLPTDGARSVDFLVPGILALAVMSTAFTGQAIATGFERSYGVLRRFGASPLPRSLLLAGKTLAVVAVELIQVAVLVAVGFALGWHPHGRPWWVALLLLVATVAFCGLGLLMAGTLRAEATLAAANGVYLLLLLVGGVIVPLSRLPGWLEAVGQALPTAAASDGLRAVLQDGAGLPVGDLLVLCAWAVGSLALAARTFRWE
>NC_015656.1|WP_013873117.1|2018582_2019524_-|ABC-transporter-ATP-binding-protein
MADDLAVEVSSLVKTYWPRSNRAIHAVNDLSLTVVAGSVTALLGPNGAGKTTTIEICEGFRRPDAGHVRVLGLDPARDGPALRPRVGVMLQSGGVYPGARAGEMLALIAAHHRDPLDVTALLERVGITEVAGMPYRRLSGGQQQRLSLAMALVGRPELVFLDEPTAGMDVQARRATWELIEQLRIAGVTVVLTTHAMDEAERLADHVVIVDHGKVLAAGSPAELTSGGAKGELRFRALAGLDIDRLELALPSGTVAREGPPGRYVIQGKVDPQMLAAVTAWCAGNGVMAEDLQVEQRSLEDVFVELTGSALRP
>NC_015656.1|WP_013873118.1|2019755_2020436_-|transcriptional-regulator
MRLRLDATRTETVTEADHSARKPDADLAGISGSAPDAAGTGKAGSGKTGTSPQRDDYAAELGRRLRAARHRRGMSLVDVQERTNGRWTAGTLGAYERGRRSLRVHRLMELAELYDVTAVVLIPSQTDRSELAGLPPLAIDLQRLRKLPPTRTGPLRRWIAIVQVLRSESSRDVLRLRRTDLLSLARLYSTTPPLLYERLRAWGTLVEPGSGQRPALPRGRRGQPRS

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_015656_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015656_7

2068379-2068476

Orphan

Consensus_repeat	Method
CCTCGTCCGGTCGAGCCGCCGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015656_7

>merge|NC_015656|7|2068379-2068476|CRISPRCasFinder
CCTCGTCCGGTCGAGCCGCCGCGTGCCTCGCCAGCTCCAGCGGCCGGAGCGCCGTCGGGTTCTCGATCAGGTGATCCTCGTCCGGTCGAGCCGCCGCG

>NC_015656|7|7|2068379-2068476|CRISPRCasFinder
CCTCGTCCGGTCGAGCCGCCGCG	TGCCTCGCCAGCTCCAGCGGCCGGAGCGCCGTCGGGTTCTCGATCAGGTGAT
CCTCGTCCGGTCGAGCCGCCGCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_015656.1\|WP_193353107.1\|2081027_2082257_+\|Na+/H+-antiporter-NhaA	unknown	unknown	gnl\|CDD\|377746
NC_015656.1\|WP_050803415.1\|2058142_2059645_-\|hypothetical-protein	unknown	unknown	unknown
NC_015656.1\|WP_131773925.1\|2071562_2072258_+\|hypothetical-protein	unknown	unknown	unknown
NC_015656.1\|WP_013871712.1\|2075982_2077071_+\|IS630-family-transposase	unknown	unknown	gnl\|CDD\|315923
NC_015656.1\|WP_013873163.1\|2079500_2080700_+\|cation:proton-antiporter	unknown	unknown	gnl\|CDD\|223551
NC_015656.1\|WP_013873145.1\|2053165_2054878_-\|circularly-permuted-type-2-ATP-grasp-protein	unknown	unknown	gnl\|CDD\|225190
NC_015656.1\|WP_013873155.1\|2070109_2070571_+\|hypothetical-protein	unknown	unknown	unknown
NC_015656.1\|WP_013873153.1\|2065346_2066762_+\|pyruvate-kinase	unknown	unknown	gnl\|CDD\|180487
NC_015656.1\|WP_013873146.1\|2055189_2056803_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NC_015656.1\|WP_013873144.1\|2052227_2053172_-\|alpha-E-domain-containing-protein	unknown	unknown	gnl\|CDD\|377234
NC_015656.1\|WP_013873159.1\|2073883_2075716_-\|glycoside-hydrolase-family-15-protein	unknown	unknown	gnl\|CDD\|225922
NC_015656.1\|WP_013873162.1\|2078950_2079433_+\|cation:proton-antiporter-regulatory-subunit	unknown	unknown	gnl\|CDD\|223564
NC_015656.1\|WP_013871712.1\|2064104_2065193_-\|IS630-family-transposase	unknown	unknown	gnl\|CDD\|315923
NC_015656.1\|WP_013873158.1\|2072298_2073582_-\|L-2-hydroxyglutarate-oxidase	unknown	unknown	gnl\|CDD\|183292
NC_015656.1\|WP_013873147.1\|2057074_2058049_+\|cation-diffusion-facilitator-family-transporter	unknown	unknown	gnl\|CDD\|223131
NC_015656.1\|WP_131772387.1\|2077364_2077688_+\|hypothetical-protein	unknown	unknown	unknown
NC_015656.1\|WP_013873161.1\|2078016_2078550_-\|PGPGW-domain-containing-protein	unknown	unknown	gnl\|CDD\|370603
NC_015656.1\|WP_013873150.1\|2060317_2060536_+\|hypothetical-protein	unknown	unknown	unknown
NC_015656.1\|WP_165001410.1\|2060685_2061528_+\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|119339
NC_015656.1\|WP_013873152.1\|2061621_2063619_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224055

Protein	Function_ID	Function_description	E-value
NC_015656.1\|WP_013873145.1\|2053165_2054878_-\|circularly-permuted-type-2-ATP-grasp-protein	gnl\|CDD\|225190	COG2308, COG2308, Uncharacterized conserved protein [Function unknown].	0
NC_015656.1\|WP_013873161.1\|2078016_2078550_-\|PGPGW-domain-containing-protein	gnl\|CDD\|370603	pfam09656, PGPGW, Putative transmembrane protein (PGPGW). Proteins in this entry are putative Actinobacterial proteins of about 150 amino acids in length, with three predicted transmembrane helices and an unusual motif with consensus sequence PGPGW.	6.65192e-14
NC_015656.1\|WP_013871712.1\|2075982_2077071_+\|IS630-family-transposase	gnl\|CDD\|315923	pfam13358, DDE_3, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	8.1237e-13
NC_015656.1\|WP_013873163.1\|2079500_2080700_+\|cation:proton-antiporter	gnl\|CDD\|223551	COG0475, KefB, Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism].	7.08043e-49
NC_015656.1\|WP_165001410.1\|2060685_2061528_+\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|119339	cd06558, crotonase-like, Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.	7.75386e-22
NC_015656.1\|WP_013873153.1\|2065346_2066762_+\|pyruvate-kinase	gnl\|CDD\|180487	PRK06247, PRK06247, pyruvate kinase; Provisional.	0
NC_015656.1\|WP_013873146.1\|2055189_2056803_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	6.46181e-168
NC_015656.1\|WP_013873144.1\|2052227_2053172_-\|alpha-E-domain-containing-protein	gnl\|CDD\|377234	pfam04168, Alpha-E, A predicted alpha-helical domain with a conserved ER motif. An uncharacterized alpha helical domain containing a highly conserved ER motif and typically found as a tandem duplication. Contextual analysis suggests that it functions in a distinct peptide synthesis/modification system comprising of a transglutaminase, a peptidase of the NTN-hydrolase superfamily, an active and inactive circularly permuted ATP-grasp domains and a transglutaminase fused N-terminal to a circularly permuted COOH-NH2 ligase domain.	5.16439e-103
NC_015656.1\|WP_013873159.1\|2073883_2075716_-\|glycoside-hydrolase-family-15-protein	gnl\|CDD\|225922	COG3387, SGA1, Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism].	2.60316e-136
NC_015656.1\|WP_013873162.1\|2078950_2079433_+\|cation:proton-antiporter-regulatory-subunit	gnl\|CDD\|223564	COG0490, COG0490, Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism].	3.23341e-50
NC_015656.1\|WP_013871712.1\|2064104_2065193_-\|IS630-family-transposase	gnl\|CDD\|315923	pfam13358, DDE_3, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	8.1237e-13
NC_015656.1\|WP_013873158.1\|2072298_2073582_-\|L-2-hydroxyglutarate-oxidase	gnl\|CDD\|183292	PRK11728, PRK11728, L-2-hydroxyglutarate oxidase.	0
NC_015656.1\|WP_013873147.1\|2057074_2058049_+\|cation-diffusion-facilitator-family-transporter	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	1.83915e-40
NC_015656.1\|WP_193353107.1\|2081027_2082257_+\|Na+/H+-antiporter-NhaA	gnl\|CDD\|377746	pfam06965, Na_H_antiport_1, Na+/H+ antiporter 1. This family contains a number of bacterial Na+/H+ antiporter 1 proteins. These are integral membrane proteins that catalyze the exchange of H+ for Na+ in a manner that is highly dependent on the pH.	1.15319e-148
NC_015656.1\|WP_013873152.1\|2061621_2063619_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	5.15818e-165

>NC_015656.1|WP_013873153.1|2065346_2066762_+|pyruvate-kinase
MSRRAKIVCTLGPATSSPERIRELVEAGMDIARLNLSHGSHEQHAQTYLQIRAASDAVGRSVGILIDLQGPKIRLGKFASGPVTLAPGDRFTITTDDILGDQHRVGTTFSGLTSDVTAGDRILVDDGRLVLEVVDVTGSDVHTTVIVGGPVSNHKGMNIPGAALGVPALTDKDAEDLRFGLGLPADMIALSFVRSAADVEKVRAVMDEVGVRLPVLAKIEKPQAVDQLEEIVEAFDGLMIARGDLGVELPLQVVPLVQKRGVSWARERAKPVIVATQVLESMVHAPRPTRAEASDCANAVLDGADAIMLSAETSVGEYPVEAVATMARIIETAETDLGRLPPLRTRPRTVGGALAEAAANVGSAMGARYLVAFSQSGDTARRLARYRSPIPLLAFTPVPAVRSQLALLWGVETFLVPFAHSTDEMVRQVDSALLQLERCKPGELVVVVAGTPPGVAGMTNTIRVHRIGEEV
>NC_015656.1|WP_013871712.1|2064104_2065193_-|IS630-family-transposase
MPGPSADPIELSSAERAVLEGWARRRKTAQALALRSRIVLACADGGTNSGVAAELGITRGTVAKWRERFAVDRLEGLSDEARPGAPRKVTDAQVEAVIARTLEEKPPNGDTHWTSRSMARASGLSQSTVSRMWRAFGLKPHLVETWKLSTDPLFVDKVRDVVGVYLDPPEKAIVLCVDEKSQVQALDRTAPVLPLMPGTPQRMTHDYVRHGTTSLFAALDPTSGSVIAQTFRRHRHQEFLRFLKLIDSSVPKGYDLHLVLDNYATHKTPAVKNWLLRHPRFHLHFTPTSASWMNLVERWFAELTTRKLRRSTHRSVVELEADIRRWINAWNKDPKPFVWAKTADEILETLAAYCQRINDSGH
>NC_015656.1|WP_013873152.1|2061621_2063619_+|ATP-binding-cassette-domain-containing-protein
MRFAEDGPRVSARAFQRDRSVVRQKLRPGTLRRIAGFARPYRRMLVGFLVLIVISAALGATTPLIYKAIIDEGIIPGRVGVVEALAVLVGLIAVVDALLALAQRWFSARIGEGLIFDMRAKLFDHVQRQPLAFFTRTQTGALISRLNNDVLGAQSAFTGTLSSVLSNIVSVGFVLAAMIALSWQTTVVSLLLLPVFVVPARLLGPKLAELTRESYGLNAAMNTVMTERFNVSGAMLAKLYGHPARENDGFTAKAARVRDIGITQAMYGRIFFVSLTLVASLATAIVYGVGGRFAAEGTLQVGTVVALTSYLARLYGPLTQLSNVNVDVMTALVSFERVFEVLDLTPAISDRPGAVDLPPGAATIEFDDVGFRYPAAGEVSLASLESVAVLDHRPSETVLHQVSFRVAPGEMVALVGPSGAGKTTISQLVPRMYDAVSGTVRVGGHDVREITLRSLRDAVGVVTQDAHLFHDTIRANLTYARPAATPEQMWTAMDAAQIGHVVRALPDGLDTVVGDRGYRLSGGEKQRLAIARLLLKEPSIVVLDEATAHLDSESEAAVQQALATALAGRTSLVIAHRLSTVRDADRILVVENGRLVDSGRHTELLARGGLYAELYRTQFAAQNAAHHGGAGSGEASSGEAGSGEAQGSESRDAESREGASAATVG
>NC_015656.1|WP_165001410.1|2060685_2061528_+|enoyl-CoA-hydratase/isomerase-family-protein
MHEPGADEPGAHVSGPSAALPAVLAGIGRSLPGSVRLVILRITGVSSPPTGGRRVAAGERLTGDQPIDGRPLAERPADGGLAGRQSDGGTAARWPAAGDVAFQAPHEASHEALHDMGTAAGWQSALGWLSRPDLFSVAVVSGYAVDALHLALACDLRVVRDDAYLSFGDVRHGRIPALGVSRALVDLVGYSRALDLCVTGRVLSGAQAQAVGLVDRLVAPAELDRVVEELAAALLAAPRETAVEVKALLLRSRELSVADQLRAERDAQARCSSAPAGAAG
>NC_015656.1|WP_013873150.1|2060317_2060536_+|hypothetical-protein
MAELRKGTRITGAERDKLASELRKKYEAGQSIRLLAESSGRSYGFVHRILSESGTTLRGRGGATRGSKKKSA
>NC_015656.1|WP_050803415.1|2058142_2059645_-|hypothetical-protein
MADVPITTAPSGSGMGESGRPGIRERMRDRPSPGTDSAQPAEIALWIAAIAGCLGLAALARAAAGQGWDPLPAAFGGLPFTADRRPDVSPASLLAPAVAAVIVLAAWRGVHTRLRWIPLLVAGYVAALGWAVALAAGNAHLEALTAGNARSGPADVLAVGASTASDGHLPDLGAADADLAALLRTFTEHTGADSYGARARPPGPTLLVWALAQLGITAPAALGAVLTALGAVTVPLVAIAVRSLCHEAAARRLLPVLVLAPWALWTAASVDAVTAAVGAAFVTLGVVGSEPGRRLWWAVACGLFFGVATLFDYAMPWLGATVVATYFVRRRPLLNVITGGCFLVPLSLLSLWGFSWPDGLAAAREGAAHTAARAGLAGAATLPESLTQLPVGLAVVLVACGPLIIRAVRRIRLTPGWPFLVGAVPAVLFGVLTGLAATALEWSWLPFYCWLVVPALAPDPRPSDPGDTARAGTLPLALTIAGALTALIAQTLLNTAPPLP
>NC_015656.1|WP_013873147.1|2057074_2058049_+|cation-diffusion-facilitator-family-transporter
MSAEGGTRAVVAALVANLGIALAKFVAFLITRSSSMLAESIHSLADSGNQGLLLLGRRRATRPADEEHPFGYGRSRYIAGFLVGIVLFSVGGLFSVYEGVEKLRHPHHLDNGVVAVVVLLLAIGLEAFSFRTAIHETRQVKGDASWWGFIRTARAPELPVVLLEDLAALVGLLLALGGVGLTLLTDDPIWDGAGTLAIGILLLVVAVIVAAETQAMLVGEAATPATVAVIRDVLGRSPHITDVIHIRTLHLGPDELLVAAKIVLDVELTVPAVAAVINDAETRLRAAVPIAHRIYLEPDLLHPPVDPPAVNEPTAARISTPPGH
>NC_015656.1|WP_013873146.1|2055189_2056803_+|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MITASDLELRAGARTLIEAVSFRIQPGDRIGLVGRNGAGKTTLLKTLARETLPFAGKIDVRGELGYLPQDPRSGDPSGTVRDRVLSARGLDALLREMEKLHVEMAELVDETARDTAIRRYGRLEERFGTLGGYAAEAEAARICSALGLQDRVLAQRLETLSGGQRRRVELARILFAGAGDNQATLLLDEPTNHLDADSIVWLREFLRSHDSGLVVVSHDVDLLDRCVNKVFYLDATRAALDVYNVNWKTYLSQRELDERRRRRERANAEKKIDALKAQADKMRAKATKARAAHQMDRRAERLAAGLAEVRVADRVAKLRFPDPAPCGRTPLTATGLSKSYGSLEVFAGVDLAIDRGARVVVLGLNGAGKTTLLRILAGAESPDTGAVHPGHGLRLGYYAQEHETLDTDRSVLDNMRAAAPGTSDVELRRILGAFLFSGDSVDQLAGTLSGGEKTRLALAGLVCSAANVLLLDEPTNNLDPASRDEVLAALATFRGAVVLVTHDPGAVEALAPEKVLMLPDGVEDSWSADLAELITLA
>NC_015656.1|WP_013873145.1|2053165_2054878_-|circularly-permuted-type-2-ATP-grasp-protein
MADLFEGYAAQATQAWDEVFEAPDTPRPLYASLYDALRPLSSSDLAARKAALDRAFRDAGITFNLFGEERPFPLDLVPRLLDNSEWDVIERGVTQRVRALEAFLTDIYGRAEVLADGIVPRRLVLSSAHFHRAAHGIDPPNGVRAHVSGIDLIRDEQGGFRVLEDNVRVPSGVSYVVENRRAMTRVFPELFATHRVRPVADYATHLLHALRAAAPPDVADPTVVVLTPGVYNPAYFEHALLARQMGVELVEGRDLTVHNNNVTMRTTEGDRPVHVVYRRIDDDWLDPLHFRPESVVGCAGLLNAARAGRVTIANAVGNGVADDKLMYTYVPDLIRYYLGEEPVLANVDTYRLEDPDQRDHVLGHLDELVLKPVDGSGGKGIVIGEQASAAELDALRLKIEADPRGWIAQRVVRLSTSPTLAGDRLGPRHVDLRPFAVNDGRRVWVLPGGLTRVALPRGSLVVNSSQGGGSKDTWVLASPESSRESISPRSRPPGNVPQVADGPDVGPFPSCDQQQQQQQQREGPQPRPSQDAGPGQGQRQEPRQGQSEHGQSRSETIGEQARRLNGPAAC
>NC_015656.1|WP_013873144.1|2052227_2053172_-|alpha-E-domain-containing-protein
MLSRIAESLFWIGRYSERAEHTARILDVHVQRVLEDPWLDETSAGRELLAVMGMPAPGTAADSRQVTELLAFDPGNPSSITGAVGAARENARGARDVISSEVWECLNATWNDLPHSEQLARRLGPHVFFRYIRERTAMLAGLVDATLARDDGWRFLILGRSLERVDMTARLLSSSISEDPASQSWVSLLRSCGAHEAYLRTYRRAVDAARVAEFLLLDRLFPRSVYWSLSMAEQILAELDGTRREARFTVDDMARRIVGRARTELEFRSVDELVDDMPDLLVSLQRTCSTVSEAVTHRYFARNAPRSWATEVPA
>NC_015656.1|WP_013873155.1|2070109_2070571_+|hypothetical-protein
MEPEPGVGAEPGVGGRFAGVLLTVAGGLGGIAATLPWSTISDGEETRTFTGLTVGDGRITLMVAVVLLVIGAAHVSGRRPGGTEAAVATLLGAGVAVFAVMDLVAGPASLSSFRTLAADQISVAPASGLVLTLVAGLLALVGGWLLRRGRHGG
>NC_015656.1|WP_131773925.1|2071562_2072258_+|hypothetical-protein
MAGTPVAGSLSWAHPAAGNAANGPGKAGPPDGGAEPGFLWGAPVGARPGETGGGPAGYTGGTGTTAGDPAHAGERLVGLLGGLLVLVAGATAIVGSVMTWATITAFDIMELPLRGTEAGRYYGGTTALLGVLAVVLGGMLTGRDRNGWRWILTAAIGLTIILVAVIDMIRLLRVDQLGGIELDLSVELGPGLWITLLSGLFTVTGALLARFLPVRPREGRGGPGGPGGRDS
>NC_015656.1|WP_013873158.1|2072298_2073582_-|L-2-hydroxyglutarate-oxidase
MAGRVAVIGGGILGLAVARRIQQVDPAATVTLFEKEHDVARHQSGHNSGVVHAGLYYQPGSLKATLCRRGVVLLKEYCATHGIRYDECGKVVVAVDHSELGRLTDIARRAQANGVPDTTMLDGHDLRRYEPHARGVAALHSPTTAIVDYRAVARRLRDSVQDTGGTVRTGSEVVAVEERPDGVHLGLRVRGNIRVPPNGTHATASRAGGTVAAVSTVAGPFDLLVACAGLQSDQVAALTDEDPSPQIVPFRGDYWLLRPERRGLVRGLIYPVPDPRYPFLGIHLTRRVDGNVLVGPNAVLATAREGYTGLTVRGSELRQTLAWPGFRTMARRHWRTGAREILRTASRHAFIAEARRYVPQLQAADVVRGPSGVRAQAVARDGALVDDFVLSIRGKIVHVRNAPSPAATASLAIAEHIVDRIVAEPAA
>NC_015656.1|WP_013873159.1|2073883_2075716_-|glycoside-hydrolase-family-15-protein
MPSRIEDYALIGDTHSAALVSRDGSIDWLCLPRFDSPACFAALLGDENSGRWRIAPVDPVLAVSRRYRGDTLVLETDMTTTSGTVRIVDAMYPRSGEHLVLRLVEGIEGTVRMRSETRIRFDYGSIVPWVRRFDDHTVVAVAGPDAVTLRTTAPMEGHDMATYSQFTVSAGQSVPFSLTWCPSHRPTHAHIDVRRAIDLTESWWADWMAGCTYDGQWQDAVRRSLITLKALTYAPTGGIVAAVTTSLPEMIGGVRNWDYRYCWLRDATITLLALLDAGFTSEATAWREWLLRAVAGDPSQVQIMYGVGGERRLPEYEVPWLPGYEGSAPVRVGNGAVDQFQLDVYGEVLDALHVARVATDVDGQDDSWALQSKLMEFLETGWRKPDEGIWEVRGPRRDFVHSKVMAWVAVDRAVKGITEWGLPGPLDRWTALRTEIHNEVCARGFDPARNTFTQFYGSTELDAALLNIPLVGFLPATDPRAVGTVAAVERELVQDGFVLRYPTAQDGAVDGLPAGEGAFLACTFWLADNYALSGRVREAQELFERLLALRNDVGLLAEEYDPALGRLVGNFPQAFSHVPLVNTARTLTDALRGRPRSRTDRAYPPGHFFG
>NC_015656.1|WP_013871712.1|2075982_2077071_+|IS630-family-transposase
MPGPSADPIELSSAERAVLEGWARRRKTAQALALRSRIVLACADGGTNSGVAAELGITRGTVAKWRERFAVDRLEGLSDEARPGAPRKVTDAQVEAVIARTLEEKPPNGDTHWTSRSMARASGLSQSTVSRMWRAFGLKPHLVETWKLSTDPLFVDKVRDVVGVYLDPPEKAIVLCVDEKSQVQALDRTAPVLPLMPGTPQRMTHDYVRHGTTSLFAALDPTSGSVIAQTFRRHRHQEFLRFLKLIDSSVPKGYDLHLVLDNYATHKTPAVKNWLLRHPRFHLHFTPTSASWMNLVERWFAELTTRKLRRSTHRSVVELEADIRRWINAWNKDPKPFVWAKTADEILETLAAYCQRINDSGH
>NC_015656.1|WP_131772387.1|2077364_2077688_+|hypothetical-protein
MLGALALAGLIAFGIYATVVGPSPRVEAVVYFTPTATDAQKDAVRAACPTAGEAVQEPPDHNTAQSSRVYPLRYNITFASPADKAAVYRCVHAQSNVIGISEFTQGQ
>NC_015656.1|WP_013873161.1|2078016_2078550_-|PGPGW-domain-containing-protein
MLNRSARIIRRIVVSAVGVAVLGLGVALLALPGPGFLVIALGFFVLSLEYEWARRQFEQARRRAADLADQAAASVWSSAFTILFGLGMIAVGILWIVVETLPFSSPWTGGSVVFGGLVILSTILFSLWQAKQARDAGEPTPAELLDLKEEEHHRRVSATSSSTSAPPGAPPTSSTDE
>NC_015656.1|WP_013873162.1|2078950_2079433_+|cation:proton-antiporter-regulatory-subunit
MDVEETMLPGIGLRHDFRTRSGRRVGVVSHHGGRRELVIYDTDDMDTCSESIPLTAEESDALAELLGAPHIVERLNNLGKAFAGIVGEQIKITPGSPYDGQPLGETHARTRTGASIVAVVRDQQVIASPRPDFGFVAGDVVVVVGTPENTAAVAELFRVG
>NC_015656.1|WP_013873163.1|2079500_2080700_+|cation:proton-antiporter
MDIAATFLELGAVLFTLGLLGHCATIVGISPIPFYLLGGLAFGHGGLFPLGASEEFIEVGAEIGVVLLLLTLGLEYTAQELIDGLRRQAPTGALDLTLNALPGVAAAFLLGWGPLAAVVLGGVTAISSSGIIAKVLTDLGRIGNRETPVVLSVLVLEDLAMAVYLPILTALLAHQTLAQGSVTLLVALAALVCVLVLALRYGRQVSRLVHNPNADPNSEILLLRLMGLALLVAGAAQQVRVSAAVGAFLVGIAVSGPVAEGAREVLTPLRDLFAAVFFVFFGLQTEPSEIPPVFLPALLLALAGVATKVFTGWWAARKAGIGTMGRYRAGAALVARGEFSIVIAGLAVVADVEPKLGAFAACYVLIMAIVGPLAARVVEPIVRKITRRSRRKTVTSLSA
>NC_015656.1|WP_193353107.1|2081027_2082257_+|Na+/H+-antiporter-NhaA
MVDGQSAVTGRVSQTLAARGAFAEFLRRETTGGFLLLAATALALLWANLAGGSYHDVWRADLGFGPSWLHLTHLTAGAWVADGLLAVFFFVAGLELKRELVVGELADRRAAVLPVAAAAGGMIVPALVFLAVSWGAPGAVDGWAIPIATDIAFALGVLSLAGANVPASLRVLLLSLAVVDDLGAIALIAVLFTRGLVPVWLVAAVVLLVGYAFAQRRRWRSPALYVPLALALWMCVHASGVHATVAGIGLALLTRVRPDPGEQAAPALRLEHRLHPFSAGLVVPLFALAATGVPVTASALGAVAEDPVSQGVIAGLVVGKTAGIVGGAWLAVRAGVARLPADLGWRAVMPIGVLGGIGFTVSLLMSRLALDDADAQQRAATAVLVASTLASVLAMIALRLSGAGRARAE

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_015656_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015656_8

2189089-2189171

Orphan

Consensus_repeat	Method
CCGCGTTCCCCGCGGGCGGGCACG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015656_8

>merge|NC_015656|8|2189089-2189171|CRISPRCasFinder
CCGCGTTCCCCGCGGGCGGGCACGCCCCCATTCCCGCTGTCCCACGTTTCGCGTAGGTGCCGCGTGCCCCGCGGGCGGGCACG

>NC_015656|8|8|2189089-2189171|CRISPRCasFinder
CCGCGTTCCCCGCGGGCGGGCACG	CCCCCATTCCCGCTGTCCCACGTTTCGCGTAGGTG
CCGCGTGCCCCGCGGGCGGGCACG

Protein	Signature genes	Signature genes Name	Protein_function
NC_015656.1\|WP_013873237.1\|2187831_2188965_+\|cell-division-protein-ZapE	unknown	unknown	gnl\|CDD\|224402
NC_015656.1\|WP_085948546.1\|2183111_2184080_+\|3'(2'),5'-bisphosphate-nucleotidase-CysQ	unknown	unknown	gnl\|CDD\|238816
NC_015656.1\|WP_043603312.1\|2189766_2191518_-\|malto-oligosyltrehalose-trehalohydrolase	unknown	unknown	gnl\|CDD\|274114
NC_015656.1\|WP_083828470.1\|2181168_2182569_-\|adenylyl-sulfate-kinase	unknown	unknown	gnl\|CDD\|180124
NC_015656.1\|WP_083828211.1\|2200250_2201492_-\|ATP-grasp-domain-containing-protein	unknown	unknown	gnl\|CDD\|180883
NC_015656.1\|WP_013873231.1\|2179979_2180759_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|212491
NC_015656.1\|WP_131773931.1\|2193497_2194268_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|183100
NC_015656.1\|WP_013873244.1\|2195708_2196491_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224041
NC_015656.1\|WP_157490996.1\|2178702_2179350_-\|DUF222-domain-containing-protein	unknown	unknown	gnl\|CDD\|367155
NC_015656.1\|WP_043605827.1\|2184381_2185296_+\|sulfate-adenylyltransferase-subunit-CysD	unknown	unknown	gnl\|CDD\|235375
NC_015656.1\|WP_013872077.1\|2175207_2176470_-\|IS4-family-transposase	unknown	unknown	gnl\|CDD\|379017
NC_015656.1\|WP_013873246.1\|2197607_2198828_-\|hypothetical-protein	unknown	unknown	unknown
NC_015656.1\|WP_013873243.1\|2194516_2195575_+\|aliphatic-sulfonate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270229
NC_015656.1\|WP_050803435.1\|2176629_2177139_+\|DUF2278-family-protein	unknown	unknown	gnl\|CDD\|378365
NC_015656.1\|WP_013873240.1\|2191803_2192598_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
NC_015656.1\|WP_013873235.1\|2185468_2186713_+\|50S-ribosome-binding-GTPase	unknown	unknown	gnl\|CDD\|180120
NC_015656.1\|WP_013873245.1\|2196578_2197562_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381312
NC_015656.1\|WP_131772405.1\|2186744_2187548_-\|pyrimidine-reductase-family-protein	unknown	unknown	gnl\|CDD\|184482
NC_015656.1\|WP_013873247.1\|2198824_2200162_-\|diaminopimelate-decarboxylase	unknown	unknown	gnl\|CDD\|143501
NC_015656.1\|WP_013873241.1\|2193288_2193519_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_015656.1\|WP_013873237.1\|2187831_2188965_+\|cell-division-protein-ZapE	gnl\|CDD\|224402	COG1485, COG1485, Predicted ATPase [General function prediction only].	2.17979e-57
NC_015656.1\|WP_085948546.1\|2183111_2184080_+\|3'(2'),5'-bisphosphate-nucleotidase-CysQ	gnl\|CDD\|238816	cd01638, CysQ, CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine biosynthesis (a principal route of sulfur assimilation).	5.97083e-65
NC_015656.1\|WP_043603312.1\|2189766_2191518_-\|malto-oligosyltrehalose-trehalohydrolase	gnl\|CDD\|274114	TIGR02402, Malto-oligosyltrehalose_trehalohydrolase, malto-oligosyltrehalose trehalohydrolase. Members of this family are the trehalose biosynthetic enzyme malto-oligosyltrehalose trehalohydrolase, formally known as 4-alpha-D-{(1->4)-alpha-D-glucano}trehalose trehalohydrolase (EC 3.2.1.141). It is the TreZ protein of the TreYZ pathway for trehalose biosynthesis, and alternative to the OtsAB system. [Energy metabolism, Biosynthesis and degradation of polysaccharides].	0
NC_015656.1\|WP_083828470.1\|2181168_2182569_-\|adenylyl-sulfate-kinase	gnl\|CDD\|180124	PRK05537, PRK05537, bifunctional sulfate adenylyltransferase/adenylylsulfate kinase.	2.0555e-93
NC_015656.1\|WP_083828211.1\|2200250_2201492_-\|ATP-grasp-domain-containing-protein	gnl\|CDD\|180883	PRK07206, PRK07206, hypothetical protein; Provisional.	9.54768e-113
NC_015656.1\|WP_013873231.1\|2179979_2180759_-\|SDR-family-oxidoreductase	gnl\|CDD\|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	1.95606e-61
NC_015656.1\|WP_131773931.1\|2193497_2194268_+\|ABC-transporter-permease-subunit	gnl\|CDD\|183100	PRK11365, ssuC, aliphatic sulfonate ABC transporter permease SsuC.	2.49325e-78
NC_015656.1\|WP_013873244.1\|2195708_2196491_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224041	COG1116, TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism].	9.68396e-96
NC_015656.1\|WP_157490996.1\|2178702_2179350_-\|DUF222-domain-containing-protein	gnl\|CDD\|367155	pfam02720, DUF222, Domain of unknown function (DUF222). This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.	4.08039e-05
NC_015656.1\|WP_043605827.1\|2184381_2185296_+\|sulfate-adenylyltransferase-subunit-CysD	gnl\|CDD\|235375	PRK05253, PRK05253, sulfate adenylyltransferase subunit CysD.	0
NC_015656.1\|WP_013872077.1\|2175207_2176470_-\|IS4-family-transposase	gnl\|CDD\|379017	pfam13006, Nterm_IS4, Insertion element 4 transposase N-terminal. This family represents the N-terminal region of proteins carrying the transposase enzyme, DDE_Tnp_1 (that was Transposase_11), pfam01609, at the C-terminus. The full-length members are Insertion Element 4, IS4. Within the collection of E.coli strains, ECOR, the number of IS4 elements varies from zero to 14, with an average of 5 copies/strain.	8.49559e-38
NC_015656.1\|WP_013873243.1\|2194516_2195575_+\|aliphatic-sulfonate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270229	cd01008, PBP2_NrtA_SsuA_CpmA_like, Substrate binding domain of ABC-type nitrate/sulfonate/bicarbonate transporters, a member of the type 2 periplasmic binding fold superfamily. This family represents the periplasmic binding proteins involved in nitrate, alkanesulfonate, and bicarbonate transport. These domains are found in eubacterial perisplamic-binding proteins that serve as initial receptors in the ABC transport of bicarbonate, nitrate, taurine, or a wide range of aliphatic sulfonates. Other closest homologs involved in thiamine (vitamin B1) biosynthetic pathway and desulfurization (DszB) are also included in this family. After binding their ligand with high affinity, they interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. These binding proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	9.26852e-57
NC_015656.1\|WP_050803435.1\|2176629_2177139_+\|DUF2278-family-protein	gnl\|CDD\|378365	pfam10042, DUF2278, Uncharacterized conserved protein (DUF2278). Members of this family of hypothetical bacterial proteins have no known function.	4.02213e-18
NC_015656.1\|WP_013873240.1\|2191803_2192598_+\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	2.82723e-36
NC_015656.1\|WP_013873235.1\|2185468_2186713_+\|50S-ribosome-binding-GTPase	gnl\|CDD\|180120	PRK05506, PRK05506, bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional.	0
NC_015656.1\|WP_013873245.1\|2196578_2197562_-\|aldo/keto-reductase	gnl\|CDD\|381312	cd19086, AKR_AKR11C1, AKR11C family of aldo-keto reductase (AKR). Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.	1.2661e-100
NC_015656.1\|WP_131772405.1\|2186744_2187548_-\|pyrimidine-reductase-family-protein	gnl\|CDD\|184482	PRK14059, PRK14059, pyrimidine reductase family protein.	2.20646e-86
NC_015656.1\|WP_013873247.1\|2198824_2200162_-\|diaminopimelate-decarboxylase	gnl\|CDD\|143501	cd06828, PLPDE_III_DapDC, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase. Diaminopimelate decarboxylase (DapDC, EC 4.1.1.20) participates in the last step of lysine biosynthesis. It converts meso-2,6-diaminoheptanedioate to L-lysine. It is a fold type III PLP-dependent enzyme that contains an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain, similar to bacterial alanine racemases. DapDC exists as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. Homodimer formation and the presence of the PLP cofactor are required for catalytic activity.	2.30031e-159

>NC_015656.1|WP_013873237.1|2187831_2188965_+|cell-division-protein-ZapE
MPERLVDRHPEVLPDDLVAALLPPPRFNDVRFDTYRPDPAEPSQAAAVVALGQFASRVAGGGRAGESAGGRGLLRFGRRNSSGRSTRHGGPVAATGAGPTRPGVYLDGGFGVGKTHLLASLWHAVPGPKAYGTFVEITSLVGALGFARTVDALAGLRLLAIDEFELDDPGDTVLVSTLLTRLVEAGVRLAATSNTQPEDLGAGRFGADDFLREIQGLSAQFHVLRVEGEDFRHRGLPKPPVPLGDQEVSRRAAATPTASEDDFASLCAHLGELHPSRYGALVDDVGLVCLHGVAQVVDQAVALRLVVLADRLYDRSVPVAVSGRPFDELFSPEMFAGPHRKKFQRAVSRLSALARDGGADEMVVREGSASSGGRPAA
>NC_015656.1|WP_131772405.1|2186744_2187548_-|pyrimidine-reductase-family-protein
MGSADAADSTDLASTADLADGTGVATSAGAGAADAVDLDVCYRLPPLATGQVHVRSNFVSSIDGATEVDGRSGALGGSADRRVFRLLRWLADVVLVGAGTAVAEDYGPVVVPPDRRERRVAAGQNAVPPIAVVSAALRLEPSARLFAAPVRPLVLTCEAAPPARRGALAEVADVLICGERTVDPAVALRALGERGLGRVLCEGGPSLHADLADAGLLDELCLTFAPLLAGPDHLRMVRGRRWRAPLTMTLGHVLEEDGNLFLRYLRR
>NC_015656.1|WP_013873235.1|2185468_2186713_+|50S-ribosome-binding-GTPase
MRELLRVATAGSVDDGKSTLIGRLLFDTKSLFSDQLAAVERTSRERGDGYVDLALLTDGLRAEREQGITIDVAYRYFATPKRSFILADTPGHVQYTRNMVTGASTADLALLLVDARRGVLQQTRRHAFLASLLRVPHLVLCVNKMDLVGFDEAVFEKIKDEFRAFAAKLEIVDVATIPISALGGDNLVSRSPSTPWYEGTSLLHHLEELHIASDRNLIDVRFPVQWVVRPRTDELHDYRGYAGQVAGGVLRPGDEVIVLPSGLTSRIAAIDTYDGPVAEAFPPMSVTIRLEDDLDVSRGDMIARPANQPTVGQDVDLMVCWMVDAPLRPRARLAIKHTTRSVRSVIKNIAYRVDVDTLHRDESAAELRLNDIGRVTVRTTTPLCFDPYRRNRATGSVILIDEATGATVGAGMLL
>NC_015656.1|WP_043605827.1|2184381_2185296_+|sulfate-adenylyltransferase-subunit-CysD
MPAIGYELTHLQTLESEAIHIFREVAAEFERPALLFSGGKDSIVMLRVAEKAFWPAKLPFPLVHIDTGHNFPEVMEFRDARAAQLSARLVVGSVQDAIDAGTITEDTRPGASRNQLQTPVLLDTIEENRFDAVFGGARRDEEKARAKERVYSFRDEFGQWDPKNQRPELWSLYNGRHRPGEHIRVFPLSNWTELDIWRYIAQENLEIPSIYYAHTREVVERDGMLLAVTALTPPLAGERVLSRQVRYRTVGDMSCTGAIESSAVAIDEVIAEVAATRITERGATRADDRVSEAAMEDRKREGYF
>NC_015656.1|WP_085948546.1|2183111_2184080_+|3'(2'),5'-bisphosphate-nucleotidase-CysQ
MSSQRPAGAGGEVPGISADAATGGPAPGDSPSDDPVSAAPVSGGPVSGGPASGGPAVRDLPADVPVLDDAALAARLATDAGALLLRIRVELGFADPAALRDAGDARSQALLAAALARHRGQDAVLSEEAIDDPARLTARRVWIIDPLDGTREFSEPGRSDWAVHVALWQDGELAAGAVALPAQGITLATGGPSAVPARSAAPVAPAPPAGGGGPRLVASRTRAPALVTTVAEALGGTVVPLGSAGAKVAAVVRGTADAYLHAGGQYEWDSAAPVAVARAVGLHTSRLDGSALVYNRPDPYQPDLLVCRPELAAGILALVARG
>NC_015656.1|WP_083828470.1|2181168_2182569_-|adenylyl-sulfate-kinase
MLAALHLTEVVGSALSGTVEGLRLPEHPDYPELRFTPAALRAELLRRGWTAPNEPAPVAVWADGLLHTADLDRIEALGAAGGAVVVLAPVGGADPADARHHLRIRCLKAALATLSDVRALLALVPVQPVTRLTESVAFGPDTVIRFETVTDGGRPTAAGHAVSGRAATAGRQPAGRPGTGQERSTGRGAGGRDGSSGGGGGDGQYQRNAGQETDDRDSEPALAGEVAYRTQVCLAYGFSAMTVGPAPSAPGAAALSMLLDRGTRLPPALTPPAVAAELVRAQPPRSERGLTVLFTGLSGSGKSTLAKLLVCRLLERGDRRVTLLDGDVVRLHLSKGLGFSREDRNANVLRIGFVAASVTAVGGTAVCAPIAPYDDVRHQVRTMVEDSGGGFVLVHVATPLQVCEARDRKGLYAKARAGIIPTFTGVSDPYEEPTDADIVIDTVDASPHDAVQTVLSHLRTDGWLAP
>NC_015656.1|WP_013873231.1|2179979_2180759_-|SDR-family-oxidoreductase
MDLALGGKIALVTGGSRGIGRAVAHRLAAEGCGVGICARTRDDLAAVEGELGRLGVPTFTHTADVTAAGGVEEFVDGAAGALGGVDLLVANVGATVGGGLLESTPRDWADTFELNVGHVVRAVRAAVPHMRHRSGGAIVVIASISGWKPAPRAQYGAAKAAEIYLAGAFACELAADNIRVNTVSPGSILIPGGGWEAYRQRNPASFAEFEGRNFPAGRLGTAEEVADVVTFLLSDRARWINGAHIPVDGAQGRPTANGY
>NC_015656.1|WP_157490996.1|2178702_2179350_-|DUF222-domain-containing-protein
MRCAGCAGCAGLPAGEGDDAAGARRRHAHAREDRQVHLRPAEDGMAELWALLPAVDAQAAYQRLDALARQAVDSPDETRGMGARRADAFVDLLLGRDRGSDVTIEVGVLVSAAALAGDGHSTSSEQGTRRISISRPRNNRLKDGRPRNGRLHNRKIRNSNISDSRHGDRWERCEKKEQQPRSGHEQNRTGQRSRYRPAALLRSSCRRFPEAAWKP
>NC_015656.1|WP_050803435.1|2176629_2177139_+|DUF2278-family-protein
MSGIGVWQDGGLLFRFPDTGGWAAVFLAFQSQGWHTDDSSGHVVPDLPEVGPAPRPAPGEPDQRVRIVAALANPAGPAPETESVTLVNTSPFHIDLAGWALADQQKHRHVLRDLVIAAGDALRVTVSPPMRLGNGGGLITLLDRRGLKVDGVSYTGTQAAREGWTITFR
>NC_015656.1|WP_013872077.1|2175207_2176470_-|IS4-family-transposase
MVRLRQVVELPAVDNDRLTDRISIGVLARIVPRDLVEEVLVETKRQERRTRLLPARVMVYFTMTMCLFFDDDYEEVMRKLAGALRWLGNWQGDWKVPTTGAISQARIRLGAAPLKVLFERVAVPVAGLGTKGTWLRSRRLMAIDGFFLDAADTPENVARFGRSTNGHKASALPQVHVVALAECGTHAIVSAAVGPRASDERALAATLLDACEPGMLLTADRYFYSFDLWQQALDTGADLLWRVKSDLTLPVIRSLPDSSYLSIIVNPKIRGKQRNQIIADARAGRDFPEDSATPVRVIEYTVPDRTGSGTGELICLITNILNQTDIPAVELATAYHERWEIENIFDEIKTHQRGEARVLRSKLPDLVEQEIWALLLSHYAIRCLMCEAADEADVDPDRLSFMRSLRVVRRQVTDQADFSP
>NC_015656.1|WP_043603312.1|2189766_2191518_-|malto-oligosyltrehalose-trehalohydrolase
MSTFRVWVPDAKTVSVTTSTDGRETVHEMMTDEGGWWWVNVPAAGHGTDYAFLVDGDVDELPDPRSAWQPDGVHGRSRLVDHSLFSWSDNAWRGITLAGSVLYELHIGTFTPQGTFDAAIARLDHLVALGVDAVELLPVNAFAGRHGWGYDGVDLFAVHEPYGGPDGLKRFVDAAHNRGIGVIMDVVHNHLGPDGNYLSRFGPYFTDSHVTPWGPAVNLDAPGSDEVRAFIVDNALGWLRHYHCDGLRLDAVHAFADNRAVHLLEEITTAVHGLAAQQRRPLFVIAESDLNDPRVVTTREAGGHGLDAQWCDDVHHALWAALSGERQGYYSDFGGLATLAKAMEHAFVHDGTYSTFRGRSHGRPVPNHLPAHRFIVFLQDHDQVGNRAIGDRASATLSAGLLRVGAALLLTSPFTPMLFMGEEWGATTPWQFFSDHDAPGLADAIRKGRRGEFAAHGWGPDEIPDPQDEATFVRSRLDWSQLTAPRHAGLLQWYRRLTALRRTLPDLTDPALPSVHCTFDEDARWFVLRRGQVAVVCNLSDRRQPVPVEGVPFDIPAASATGFTFMPGRIELDAESVVIARLL
>NC_015656.1|WP_013873240.1|2191803_2192598_+|histidine-phosphatase-family-protein
MHIATTDDAIAWGVPAELVVVRHGQSTGNAALAAADAAGSQDAGITERNPDIPLSPLGREQAGDLGRWFASLPPERIPQIIESSPYVRARDTADIVRDELARAGRAVPPPVLDERLRDRETGVLSGLPAAARQARFPDEVRRRAHLGELYYRPPGGESLTDVALRLRSFLRDVCREQAGRRVLVAAHDAVVIILRFVLEGLTESELVALSGSVANASVTRWVADTGRLRLADYNRTGHLRPGRIRSDQPHGGHPLGGHPGAGSG
>NC_015656.1|WP_013873241.1|2193288_2193519_+|hypothetical-protein
MADQTIVQTHPVARGPRDSTDVGPDVAVRAETDAGVEAGATPEAGAGVDAGGPAEGPPPAGAPRRGAAGASGCPTG
>NC_015656.1|WP_131773931.1|2193497_2194268_+|ABC-transporter-permease-subunit
MGVPYRLISWLSPLVLLVIWEAFARSGVISTQVLPAPTKVLSTARELTASGQLPKDALISLRRAATGFVIGGGIGLALGVAVGFSRLADAVLDRPIQMIRAVPFLAILPLVIVWFGVGESGKVFLVALGVATPIYLNTVLGIRQVDPKLLELGRVIGLPQRQLIRRIVLPGALPSILNGIRLAITTAWLALVVAETVGADSGIGFMAMDAREFLRTDVIVLAILIYAAIGILSDLAARVLERRLLSWHPNYANARS
>NC_015656.1|WP_013873243.1|2194516_2195575_+|aliphatic-sulfonate-ABC-transporter-substrate-binding-protein
MSPANSLWTPTVARGAGAGTGRHVVIGRRGLSRRTFLSTVAAAGLAVPLAACGSDDSSSGGGNTSTVRLTFGTGSPEKERGELEKNLRAQGIAVQWLGPFPNHAPTMQAVTGGSADFSFGGSSTPADAAILAGSPLVYVGFGESSPRTSAILVLPKSGIRSVKDLAGKSVAVNKAGLGEFLLVAALEKYGVPKDQVKFVYLNPPDAGPAFSTGKVDAWSIWSGPREQAEVTYGAVPIFVDQDELPRQLDFRTYLVRREYAEKNPDLVRKVINAYVAEYEWQANHIEETVRIQTAAANYPDGVLQKLTANRVVTKLKLIDDDAIEKLQYGADWMTDHKVLSGKLVVADHAVKL
>NC_015656.1|WP_013873244.1|2195708_2196491_+|ABC-transporter-ATP-binding-protein
MTSQPATVPRETADAASAGGASLVRVRGLRRAYQDKVVIDGLDVDIAAGEFVALLGKSGCGKTTLLRTLAGLDQPDAGTVDVPAQRAVVFQEHRLLPWERVWRNVAIGLPRGEGQQKAAAALAEVGLSSHLEAWPITLSGGEAQRVALARALVREPKLLLLDEPFAALDALTRIKMHELVRELVARHRPAVLLVTHDVDEAITLADRVLVMRTGEIAAEHRIQLTGARGRADGDFLALRETLLAELGVLPGPGALAAVAT
>NC_015656.1|WP_013873245.1|2196578_2197562_-|aldo/keto-reductase
MRYRRFGRLGWQVSEVGMGMWGMGGGVQGWTGALDDEKIDALQRAVDLGCTFFDTAWIYGRGHSEQLLGQLVRANPDRRLYVATKVPPKDLAWPSTRKSRLEDVFPADHIEEYVGRSLDNLGLGSIDLLQMHVWEDSWAMDERWQRPLLSLKEQGVVKAVGISVNRWEPWNVLRTLETGLADAVQVIFNIFDQSPRDALFPAAAEHDIAIIARVPFDEGTLTGRLTRDTRWPEGDWRNSYFVPENLEASVERAERLRQDIPSGMSMAQAALRFILADPAVSTVIPGMRRIRHVEENIAVSDAPPPTPELLDRWRRHRWDRTPTWWSQ
>NC_015656.1|WP_013873246.1|2197607_2198828_-|hypothetical-protein
MTHQVGTYQVGMVRGIAEIGEETWARLAAGRSFYLSYPWLRWAETAAGVDTVYLAAYSRDARVVGAVPCYLWDGGTVPSMNAAYDVVAELLTPNGVALSPPERRRWLPALLVGSRAGYHGGVLVDPALAPPERERVLIRLFRAVTEHAAGSGAGSVAMLYVPETHAAECAAAWRVALDGTPGPYAAPLSAEATVRPVTREPFATPTLSARSRREWYREERRFTEAAEAIGSAPLSACVAEIGPLLGHTQRKYGASDSDEAMTRYLAGQVPFLDSHSHVLLEYDGGAVVGFALTYSWGDALAVRAAGFSDRCAPFAYFNLAVYGPVRLAMDRGLGSVELGAGSYRGKFLRGADLSPTWSLVVPPAGAPPEWLTALTGPGGDYLAARAVDGALGIRPDSTLTDPPRIR
>NC_015656.1|WP_013873247.1|2198824_2200162_-|diaminopimelate-decarboxylase
MDRFTYRDGVLYVEDVAVEDIAARFGTPVYVYSHGTLVTHLRQVADAFADLAPLICFSVKALSNIHLLRGLAAAGAGVDVVSGGELYRALLAGVPAQRIVFAGVGKSDEELRYAVRSGIRCVNVESEGEMRALARAAAECRMPAGAAVRVNPDVAVGSRTPAKTTTGRRGGKFGIDLDRVHEVYRLAVDDEWLRPEGLHFHLGSPVFHPRAYGDAVDKVLTVTEKLTADGAPVPTINIGGGFPADYEGSGVPGWSDFAAVIAPKLRSFVAAGGTVVMEPGRSIAANAGVLLASVRYLKTSGSRNVVITDTGMSHLIRTAFYDTFHFLWPARPRNGLSPVGRTGEHDQPDLARYDVAGPLCESSDYLAKDRLLPSLRPGDVLAIFTAGAYGMTMASHYNSLPRPAEVLVDGGDVRLIRRRETYEDLVSAEVDAEAGPAAAGTTKPA
>NC_015656.1|WP_083828211.1|2200250_2201492_-|ATP-grasp-domain-containing-protein
MAAHRIAIVAPFSTGSQLAPEFARHGWESVAVVEGEPPASYAASFRPDDFVEVVQAATDPAATAALLRRLGTHQVLAGSEWGVDLADQLTTLLGLPGNAHLPGRPRRDKYAMMRRLRSAGLRTPASLVTDDEEQMLTWAAHGRHWPVVVKPRDSAGSDGVVFCAGPAQARSALATLDRAYNALGLRNDGVLVQERLTGQQYFVNSVSIEGRHHVHEIWRDDRLFVREKPVYDRQRLLPARGDVQDVAVPYVLRVLDALGIREGPAHTELFVDDDGPVIIECGARLEGGVTPRGPVAATGDSQVSLTVLRYVDPAGFATRLGTPYDLRRQLHVVCLTAPYDGIMAAAGLDEIARMPGILCGSALNLRPGSRVRRTVDLFTSPGHLYLLADDERELERAYRRIRELEVQGLYLPA

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_015656_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015656_9

3036316-3036397

Orphan

Consensus_repeat	Method
GGTCATCCGCGCGCGGGACACCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015656_9

>merge|NC_015656|9|3036316-3036397|CRISPRCasFinder
GGTCATCCGCGCGCGGGACACCCAGGGCTCGGCTCCCAACCACGTCACCAACCAATCATGGTCATTCGCGCGCGGGACACCC

>NC_015656|9|9|3036316-3036397|CRISPRCasFinder
GGTCATCCGCGCGCGGGACACCC	AGGGCTCGGCTCCCAACCACGTCACCAACCAATCAT
GGTCATTCGCGCGCGGGACACCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015656.1\|WP_013873840.1\|3036407_3037094_-\|CDP-alcohol-phosphatidyltransferase-family-protein	unknown	unknown	gnl\|CDD\|223632
NC_015656.1\|WP_013873844.1\|3044060_3044492_+\|SsgA-family-sporulation/cell-division-regulator	unknown	unknown	gnl\|CDD\|377399
NC_015656.1\|WP_050803509.1\|3047690_3048311_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_015656.1\|WP_131773981.1\|3023716_3025576_-\|protein-translocase-subunit-SecD	unknown	unknown	gnl\|CDD\|235615
NC_015656.1\|WP_013873847.1\|3048720_3049581_-\|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl\|CDD\|119407
NC_015656.1\|WP_013873834.1\|3030701_3031457_-\|YebC/PmpR-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|234640
NC_015656.1\|WP_013873830.1\|3025995_3026553_-\|preprotein-translocase-subunit-YajC	unknown	unknown	gnl\|CDD\|376903
NC_015656.1\|WP_085948597.1\|3040017_3040479_-\|HIT-domain-containing-protein	unknown	unknown	gnl\|CDD\|238606
NC_015656.1\|WP_013873831.1\|3026724_3027777_-\|Holliday-junction-branch-migration-DNA-helicase-RuvB	unknown	unknown	gnl\|CDD\|234619
NC_015656.1\|WP_013873848.1\|3049631_3050531_-\|DUF3097-domain-containing-protein	unknown	unknown	gnl\|CDD\|378628
NC_015656.1\|WP_013873832.1\|3027787_3028582_-\|Holliday-junction-branch-migration-protein-RuvA	unknown	unknown	gnl\|CDD\|234645
NC_015656.1\|WP_013873838.1\|3034198_3035332_-\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340831
NC_015656.1\|WP_013873843.1\|3041366_3043007_+\|cytochrome-P450	unknown	unknown	gnl\|CDD\|365848
NC_015656.1\|WP_013873835.1\|3031467_3032202_-\|pyridoxal-5'-phosphate-synthase-glutaminase-subunit-PdxT	unknown	unknown	gnl\|CDD\|237411
NC_015656.1\|WP_043606273.1\|3050816_3051419_+\|isochorismatase-family-protein	unknown	unknown	gnl\|CDD\|238493
NC_015656.1\|WP_131772530.1\|3044837_3045884_-\|chorismate-binding-protein	unknown	unknown	gnl\|CDD\|130883
NC_015656.1\|WP_013873828.1\|3022465_3023713_-\|protein-translocase-subunit-SecF	unknown	unknown	gnl\|CDD\|237275
NC_015656.1\|WP_013873841.1\|3037543_3039760_+\|elongation-factor-G-like-protein-EF-G2	unknown	unknown	gnl\|CDD\|237186
NC_015656.1\|WP_013873833.1\|3028578_3029112_-\|crossover-junction-endodeoxyribonuclease-RuvC	unknown	unknown	gnl\|CDD\|234587
NC_015656.1\|WP_013873836.1\|3032195_3033185_-\|pyridoxal-5'-phosphate-synthase-lyase-subunit-PdxS	unknown	unknown	gnl\|CDD\|179769

Protein	Function_ID	Function_description	E-value
NC_015656.1\|WP_013873840.1\|3036407_3037094_-\|CDP-alcohol-phosphatidyltransferase-family-protein	gnl\|CDD\|223632	COG0558, PgsA, Phosphatidylglycerophosphate synthase [Lipid metabolism].	6.51394e-22
NC_015656.1\|WP_013873844.1\|3044060_3044492_+\|SsgA-family-sporulation/cell-division-regulator	gnl\|CDD\|377399	pfam04686, SsgA, Streptomyces sporulation and cell division protein, SsgA. The precise function of SsgA is unknown. It has been found to be essential for spore formation, and to stimulate cell division.	2.51806e-43
NC_015656.1\|WP_050803509.1\|3047690_3048311_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.01294e-11
NC_015656.1\|WP_131773981.1\|3023716_3025576_-\|protein-translocase-subunit-SecD	gnl\|CDD\|235615	PRK05812, secD, preprotein translocase subunit SecD; Reviewed.	5.14743e-108
NC_015656.1\|WP_013873847.1\|3048720_3049581_-\|N-acetylmuramoyl-L-alanine-amidase	gnl\|CDD\|119407	cd02696, MurNAc-LAA, N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino acids in certain cell wall glycopeptides. These proteins are Zn-dependent peptidases with highly conserved residues involved in cation co-ordination. MurNAc-LAA in this family is one of several peptidoglycan hydrolases (PGHs) found in bacterial and bacteriophage or prophage genomes that are involved in the degradation of the peptidoglycan. In Escherichia coli, there are five MurNAc-LAAs present: AmiA, AmiB, AmiC and AmiD that are periplasmic, and AmpD that is cytoplasmic. Three of these (AmiA, AmiB and AmiC) belong to this family, the other two (AmiD and AmpD) do not. E. coli AmiA, AmiB and AmiC play an important role in cleaving the septum to release daughter cells after cell division. In general, bacterial MurNAc-LAAs are members of the bacterial autolytic system and carry a signal peptide in their N-termini that allows their transport across the cytoplasmic membrane. However, the bacteriophage MurNAc-LAAs are endolysins since these phage-encoded enzymes break down bacterial peptidoglycan at the terminal stage of the phage reproduction cycle. As opposed to autolysins, almost all endolysins have no signal peptides and their translocation through the cytoplasmic membrane is thought to proceed with the help of phage-encoded holin proteins. The amidase catalytic module is fused to another functional module (cell wall binding module or CWBM) either at the N- or C-terminus, which is responsible for high affinity binding of the protein to the cell wall.	7.78785e-37
NC_015656.1\|WP_013873834.1\|3030701_3031457_-\|YebC/PmpR-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|234640	PRK00110, PRK00110, YebC/PmpR family DNA-binding transcriptional regulator.	1.60317e-140
NC_015656.1\|WP_013873830.1\|3025995_3026553_-\|preprotein-translocase-subunit-YajC	gnl\|CDD\|376903	pfam02699, YajC, Preprotein translocase subunit. See.	6.24688e-21
NC_015656.1\|WP_085948597.1\|3040017_3040479_-\|HIT-domain-containing-protein	gnl\|CDD\|238606	cd01275, FHIT, FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into three branches: the Hint branch, which consists of adenosine 5' -monophosphoramide hydrolases, the Fhit branch, that consists of diadenosine polyphosphate hydrolases, and the GalT branch consisting of specific nucloside monophosphate transferases. Fhit plays a very important role in the development of tumours. Infact, Fhit deletions are among the earliest and most frequent genetic alterations in the development of tumours.	1.5997e-64
NC_015656.1\|WP_013873831.1\|3026724_3027777_-\|Holliday-junction-branch-migration-DNA-helicase-RuvB	gnl\|CDD\|234619	PRK00080, ruvB, Holliday junction branch migration DNA helicase RuvB.	0
NC_015656.1\|WP_013873848.1\|3049631_3050531_-\|DUF3097-domain-containing-protein	gnl\|CDD\|378628	pfam11296, DUF3097, Protein of unknown function (DUF3097). This family of proteins with unknown function appears to be restricted to Actinobacteria.	2.40297e-159
NC_015656.1\|WP_013873832.1\|3027787_3028582_-\|Holliday-junction-branch-migration-protein-RuvA	gnl\|CDD\|234645	PRK00116, ruvA, Holliday junction branch migration protein RuvA.	5.87319e-66
NC_015656.1\|WP_013873838.1\|3034198_3035332_-\|glycosyltransferase-family-4-protein	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	4.81956e-75
NC_015656.1\|WP_013873843.1\|3041366_3043007_+\|cytochrome-P450	gnl\|CDD\|365848	pfam00067, p450, Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyze regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.	6.18841e-78
NC_015656.1\|WP_013873835.1\|3031467_3032202_-\|pyridoxal-5'-phosphate-synthase-glutaminase-subunit-PdxT	gnl\|CDD\|237411	PRK13525, PRK13525, pyridoxal 5'-phosphate synthase glutaminase subunit PdxT.	1.30626e-110
NC_015656.1\|WP_043606273.1\|3050816_3051419_+\|isochorismatase-family-protein	gnl\|CDD\|238493	cd01011, nicotinamidase, Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is also called pyrazinamidase, because in converts the tuberculosis drug pyrazinamide (PZA) into its active form pyrazinoic acid (POA).	1.14405e-56
NC_015656.1\|WP_131772530.1\|3044837_3045884_-\|chorismate-binding-protein	gnl\|CDD\|130883	TIGR01824, Anthranilate_synthase_component_I-like_protein, aminodeoxychorismate synthase, component I, clade 2. This clade of sequences is more closely related to TrpE (anthranilate synthase, TIGR00564/TIGR01820/TIGR00565) than to the better characterized group of PabB enzymes (TIGR00553/TIGR01823). This clade includes one characterized enzyme from Lactococcus and the conserved function across the clade is supported by these pieces of evidence: 1) all genomes with a member in this clade also have a separate TrpE gene, 2) none of these genomes contain an aparrent PabB from any of the other PabB clades, 3) none of these sequences are found in a region of the genome in association with other Trp biosynthesis genes, 4) all of these genomes aparrently contain most if not all of the steps of the folate biosynthetic pathway (for which PABA is a precursor). Many of the sequences hit by this model are annotated as TrpE enzymes, however, we believe that all members of this clade are, in fact, PabB. The sequences from Bacillus halodurans and subtilus which score below the trusted cutoff for this model are also likely to be PabB enzymes, but are too closely related to TrpE to be separated at this time.	9.18482e-99
NC_015656.1\|WP_013873828.1\|3022465_3023713_-\|protein-translocase-subunit-SecF	gnl\|CDD\|237275	PRK13022, secF, protein translocase subunit SecF.	1.66613e-117
NC_015656.1\|WP_013873841.1\|3037543_3039760_+\|elongation-factor-G-like-protein-EF-G2	gnl\|CDD\|237186	PRK12740, PRK12740, elongation factor G-like protein EF-G2.	0
NC_015656.1\|WP_013873833.1\|3028578_3029112_-\|crossover-junction-endodeoxyribonuclease-RuvC	gnl\|CDD\|234587	PRK00039, ruvC, Holliday junction resolvase; Reviewed.	1.34478e-75
NC_015656.1\|WP_013873836.1\|3032195_3033185_-\|pyridoxal-5'-phosphate-synthase-lyase-subunit-PdxS	gnl\|CDD\|179769	PRK04180, PRK04180, pyridoxal 5'-phosphate synthase lyase subunit PdxS.	0

>NC_015656.1|WP_013873838.1|3034198_3035332_-|glycosyltransferase-family-4-protein
MKIGLACPYTWDVPGGVQVHVRDLAEALVALGHEVSVITPVGDDSALPPYGVDAGHAVPVPYNGSVARLLMGPVSAARVRRWLREHDFDVLHVHEPTAPSVSLLACMLADGPIVATFHTSNPRSKILTAAHGALQPSMEKVRARIAVSEAARRTLVEHLGVDAILIPNGVSILTFERAAPLPEPVSNGSTVVFLGRIDEPRKGLDVLLAALPALVERRPEARLLVAGPGDGEAVLERVEPGLRDRVHLLGLVSDADKPRVFHSGEVYCAPNTGQESFGIVLLEAMAAGVPVVASDIDAFRRVLDDGQAGRLFPVADATALAHTLADLLADPARRGRLAERGRAVVAAYDWTVIAKRIVGVYEMVAGDRPVSLAANSV
>NC_015656.1|WP_013873836.1|3032195_3033185_-|pyridoxal-5'-phosphate-synthase-lyase-subunit-PdxS
MSEGLTAAEPASRGHGPDHGSVPTATLPGAAGAGDGAHVGTARVKRGMAEMLKGGVIMDVVTAEQARIAEEAGAVAVMALERVPADIRAQGGVSRMSDPEMIESIIEAVSIPVMAKARIGHFVEAQVLQELGVDYVDESEVLTPADPHHHIDKWRFTVPFVCGATNLGEALRRIGEGAAMIRSKGEAGTGEVSNAVVHMRTIRAEIARLSALPGDELFAAAKELRAPYELVAEVARLGALPVVLFTAGGIATPADAALMMQLGADGVFVGSGIFKSGDPARRARAIVEATTMYAHPDVIAKVSRGLGEAMVGINVSDLAPADRFADRGW
>NC_015656.1|WP_013873835.1|3031467_3032202_-|pyridoxal-5'-phosphate-synthase-glutaminase-subunit-PdxT
MVSGPWTPPAQARTGAARLGVLALQGDVREHSRALAALGVQVVEVRRPSDLGALDGLVLPGGESTTIGRLLRVFELLEPLRDAIAAGLPVFGSCAGMILLARDVLDGRPGQPLLGGLDVVVRRNAFGRQVDSFEAEIDITGVAGGPVRAVFIRAPWVEKIGDEVEVLGRVSDRIVAVRQAGVLATAFHPELTGDGRIHELFVGMVEDVRGMRAVRGTQGVQGVRGISARAYLCRAQVADGSGDR
>NC_015656.1|WP_013873834.1|3030701_3031457_-|YebC/PmpR-family-DNA-binding-transcriptional-regulator
MSGHSKWATTKHKKAVIDARRGKLFAKLIKTVEVAAKTGGGDPAGNPTLADAIAKAKSQSVPNDNIDRAVKRGSGELAGGASYEEITYEAYAPNGVAVLVECLTDNRNRAASDVRVAITRNGGSVADPGSVSYLFNRKGVVLVTKTPELGEDDVLTAVLDVGAEEVNDLGDAFEVVSEATDLNAVRVAATDAGLTVASADLSWLPSVSVPLDEEAARKVLKLVEALEDLDDVQNVWFNADISDEIMELVSA
>NC_015656.1|WP_013873833.1|3028578_3029112_-|crossover-junction-endodeoxyribonuclease-RuvC
MLVLGVDPGLTRCGLGVVDGGPGQQTSLVEVGVLRTPAADDVAARLWALERGVGEWLDRHHPDAVAVERVFSQANVRTVMGTAQAGAVAIVSAARRGLPVALYTPSEVKASVSGSGRADKTQVTFMVSRLLGLSDPPRPADAADALALALCHLSRGPALARMRAARQAAAAAGRSLR
>NC_015656.1|WP_013873832.1|3027787_3028582_-|Holliday-junction-branch-migration-protein-RuvA
MIASVAGTVAALSPDAAVVEVGGVGLLVQCAPATLAGLRVGQQARLVTTLVVRETELTLYGFADADERDVFETLQSASGVGPRLAQAVLGVHSPDSVRRAVAAEDLAALTKVPGIGRKGAQRIVLDLRDRLGPPVPAPAAGDDGVGVGGAGGDGAAPAAGTGVTAGEQVRLALLGLGYTAREADDALAAALADSLAITGADALAAVPAGNGHGNAGPGSRAGRAGPGDPRATATGTGRAGSGRAETPDPVGVLLRRALAALRPR
>NC_015656.1|WP_013873831.1|3026724_3027777_-|Holliday-junction-branch-migration-DNA-helicase-RuvB
MDVEGLVSPVAEPQERAFEAGLRPGTLAEFIGQQKVREQLMIMLEGARARARPPDHVLLSGPPGLGKTSLAMIIAREMAVPLRMTSGPAVERAGDLVAILTALAPGEVLFLDEIHRIARPAEELLYAAMEDFRVDVVLGKGPGATAIPLEIAPFTLVGATTRSGLLTGPLRDRFGFTAHMDFYDTNELIDVLVRSAALLGVHITGDGAAEVAGRSRGTPRIANRLLRRVRDYAEVRADGVVTHEVAQAALRVYDVDALGLDRLDRAVLEALVRRFNGGPVGLATLAVAVGEEPDTVEEVAEPFLVRAGLLARTPRGRIATPAAFTHLGLDPVEGLLGRSQVPLPLIDSDD
>NC_015656.1|WP_013873830.1|3025995_3026553_-|preprotein-translocase-subunit-YajC
MQVIVVAQDVAQGGGGGGFGGLFPLILLLALVVFFVVSQRRRQRTQQQVLTSLVPGALVVTTAGLYATVVEVEGSDVLLEVAPDVVCRFTRSAVVRVVSPVGDDVAHHDDHDIDHDGGPDGGHDSDEEGGHRDEDAGAADDHGTGRGPIDTTKKVDTTGSEEATGGQRRPDASGSEDPGEGTPER
>NC_015656.1|WP_131773981.1|3023716_3025576_-|protein-translocase-subunit-SecD
MALTSTWTPKLGLDLQGGTSVILTPRSTEPGKGVDGGAVNKAVDIIRERVNGLGVAEAEVKRNNTQIEISVPGRGRNDVVELVGQTAELRFREVYTSGAAVPAAPTTPPAAPEAPTATPTVPVPGATPRAPGTVSAPPAATAASPSTTTRPDVVGSGLLAQAAPTAPAGSAAPAPAASASPALGTPPAAVPPAASGQPAQPAADTPPADVVARFESLTCAPSDVRSQAAATDRPTDWVAACDRSGAVKYLLMPATVIGTDVKSATAGLASSGGAASVSTGEWVVNVSFTGTGQAKFTSLTEKTLGKQVAIVLDGVVQSAPTTNDRIAGDAQISGSFTQSSAQDLANVLRYGALPLAFEQSSAESISPTLGQDSLNAGLLAGVIGLALVTLYSFVYYRTLGIVVLSSLAVSGVLVYASVVLLGEWIGFTLTLAGIAGLILSIGVTADSFVVYFERIKDEVRENRTARVATERAWPSARRTMLSADTVSFLAAAVLYVLSVGSVRGFAFTLGLSTLIDVLIMFIFTRPVVTLLVRRPFFATSRFSGLTVAAVRGQPAAAGPAPARLAKRERAPATPAQAAAGRGTARADAAGGPEQGSRDLRSARGSRPSRPGSSGTAQGE
>NC_015656.1|WP_013873828.1|3022465_3023713_-|protein-translocase-subunit-SecF
MSWASRLYRNQSHVDFVGRRRIWYAFSALLLIVCVASMLIRGFSLGIDFKGGALFQFPSGGRSVAVAEEALSSAGVNPADSVIQELDTSQQLRVQTPTLSAEQASALQNTIEKRFEVAPTDIDISTVGASWGSTITSKALQGLAVFLVLVVVYLSVRFEWKMAVAAMTALVHDLVITMGVYSLVGFQVTPSTVIALLAILGFSLYDTVVVFDRVRENTAGMSTTNRRTYAEATNDALNETLVRSLNTSFIALVPVASLLFVGAGLLGAGTLEDLALAQFVGIASGAYSSLFFATPLLVDLKKNEPAVRALDQRVARARAAAAREPARQPKAAAAAAVGGRASDSGAAAAGQGSGSGFSDTATTPSDADERERGEPASGREPAVAGVRPPRPAAGRRPTPARRSGRKGRPSGKKRR
>NC_015656.1|WP_013873840.1|3036407_3037094_-|CDP-alcohol-phosphatidyltransferase-family-protein
MLASKARPQIQRVLDPLGERLARSSVSPDAVTIVGTIGVSGAALGFFTRGVFFVGTLVITLFVFSDLLDGLIARARGISSPWGAFLDSASDRVGDGAIFSSLILWYAGDGDSLPLCVAALISLVAGSITSYVKARAEGLGLRCDVGFAERGERLLIVLVAAGLYGLGVPYLLPAALWFLAGATVLTVTQRVVHVRRQYLRGAGAAGAAGASAAAGAPPAEPTAGPRAR
>NC_015656.1|WP_013873841.1|3037543_3039760_+|elongation-factor-G-like-protein-EF-G2
MKTTACNDRPDLEHLADVRNVILVGHTGAGKTTLAESLLAAADEGEAAQGRPAPPRHTDHDDAEHRQRTINLTVLSTTHRGMRINLLDTPGLADFIGDLRAGLRGGDAALFVVSALDGVDGFTRLLWDECAAAGTPRAIVLTKLEHPRADFAATVATCQKLFGPGVLPLYLPVRLPAADGPAPGHGGYQLIDLLSAGSAIPGAVSAAGNGTTRPTVAAARNALIEGIIAESEDESLLEQYLAGEPLAPELLLRDLETAVARGRFHPVLPVLGPAGAVGGSGDMLGAAELLDLFTRAFPSPAEHRLPVSTRPDGSSGPSLSADPDGPLAAEVIRTTTDPYVGRISLVRVFSGTLRTDTTVHVCGHGRAERGHPDHDDDGRIAGISRPAGRSGQRPAQVVRAGDLCVVAKLATAETGDTLSSPDDPILLQAWSIPRPQLPVAIRARTKSSEDKLSTALARLAAEDPSLTVEYGTESGQLVLWCMGEAHSDVVIERLRTRYGVDVDRVAPRVPLRETLRGPARGTGRHVKQSGGHGQYAICHVEVEPLPAGSGREFVDEVVGGAVPRQFIPSVEKGVLRQLDLGVAAGYPLVDIRVRLVDGKAHSVDSSDIAFQAAGALAVKNAARAAGIVLLEPVLAVCVLTPDEHVGPVTSDLAARRSRVVGIEPVGGGQSNGQAVHGSTTGRTLVRAEVPEKEMLRYAVDIRSLTQGTGTFTRDNLRYEPVPDHLAADHLGDRPGETG
>NC_015656.1|WP_085948597.1|3040017_3040479_-|HIT-domain-containing-protein
MAYIKGERPAGQQCPFCEIPSLSDEDGLVVARGETVYAVLNLYPYNSGHLMIVPYRHIPDYAALVDAETIEMALFTQHALRALRRASGAHGFNIGMNLGVVAGAGIAEHVHQHVVPRWGGDTNFMPVVGGTKVLPALLGQTRELTAAAWKETE
>NC_015656.1|WP_013873843.1|3041366_3043007_+|cytochrome-P450
MTSSQARAVDDPAESTDEAENAGDAGHTGKAHSTNADSANRAESAGGAGSASGAQPADAPGGAVGGAAIRPGPHPPGPSGQSLRTAYSFLTNPLDLLIRLRHEHGPIVRGSLGRGTVYLVNDPAAVQEILVSSQRVFAKGFRRKRMPLDEGIQPLALLLGSGLLTSSGELHRARRRLIQPLFHRQRIATYGGTFARLAEETISGWSDGQRLNIHEEMTELTLGIVTRTVFDLPMNSDLVLTIRRAIAANMGVSRRAILPGSRYLEKIPLPTTLRARNSRADLDRLIREIIADRRREGADGNDLLSLLLTTRDAETGAPLDDDAVRDEALTILLAGHETTANALSWAFHLLGNAPQAREALHAELDEVLGDRLPTLDDLPRLPYTRAVFTESIRLYPPVWIMFRRTVADHSLGGYDIPAGSTVLVSQWVMHRDPDYWPDPDGFVPQRWLEPSPTSSPTDETQPSATGPASEPRSTATRPKYAFFPFGGGSRQCIGNTFAELEAAIVLATVCRRWHLEPTPGHSVTPLPRVTLRPRSGVPVIAHRRNP
>NC_015656.1|WP_013873844.1|3044060_3044492_+|SsgA-family-sporulation/cell-division-regulator
MTIRHDSITAELALRLVVPGGAPVPVAATMRYEPADPYAVSIGFRTGADEVVEWTFARQLLSDGVRRPAGDGDVQVWPAAQSGGRIVCLSLSSPSGHALFEMPRSEVLSFLRRTYSVVPLGGESEVVDLDAELALLIWGGPQT
>NC_015656.1|WP_131772530.1|3044837_3045884_-|chorismate-binding-protein
MEVRRRPPWRTGSFMVAGGRLATGVIDITDDLAALDRGGFWAVVVDFEGAARCVRFADVRAAPSLTAIAGRPWHGPLRDVWTSSLDRDGYVAGVRRIRAEIAAGEVYQVNLCRVLSVPMAAVSGEAIAALGGALARGNPAPYAAVMYVPEADIRVISASPELFLSRRGDVVRSGPIKGTGRVAADLLEKDIAENIMIVDLVRNDLGRVACPGGVSVPALCALEAHPGLVHLVSTVEARLRPHVGWPELFAASFPPGSVSGAPKLSALRVIRDLEPAARGPYCGAVGWVDADRGLGELAVGIRTFWFAAGRLCFGSGAGITWGSDPEGEWRETELKAERLLRICSSVPT
>NC_015656.1|WP_050803509.1|3047690_3048311_-|TetR/AcrR-family-transcriptional-regulator
MDEGTAATTRRDAALGRRAARTRDAILEGARRLFLDRGYAGTRIGNITDACGISRAGFYTYFHDKREVFNALGENAYRDILKIVSCWEAMPRPCGLPDVIGWVHAYFAFMDAHGAFIFASGHSAPADEQFRNSSRRMQMRVASLLGTNLRGRQTEPTSAPEALGLSIMGMLERAWYYCRAQELPVGDDDIIRTVARLILGDLNPIH
>NC_015656.1|WP_013873847.1|3048720_3049581_-|N-acetylmuramoyl-L-alanine-amidase
MPPRWRALRPGLVVALVAVVAIVAFAVHAVRSDPPPPPLGMSGAAASPSEPTTAGAGAAARPDLMRGRTVLLDPGHNGGNAKAPAAINRKVLAGGIAKECDTVGSQTTAGYPEHAFTFDVVTRVAALLRDRGATVVLTRADGNGVGPCIDERARISNDAHADAAVSVHADGGPASGTGFHVIAPSLSPDGGNAAILAPSARLADAVGAAFERNTGETRADYIAHDGLSFRTDLGGLNLSRVPKVFIECANMRNPADAARVSDPAWRGRAAQGITDGIIAFLTAPPS
>NC_015656.1|WP_013873848.1|3049631_3050531_-|DUF3097-domain-containing-protein
MRSRDYGPDVLARSGRVRPAAPPSVEAVPGLVVEDAATGFCGAVIEVEAGGVVLEDRHGRRRAFPLAAGAFLLDGRTVTLTRPVRSAPAAPARTASGSVAVPGQPARVARASRIYVEGLHDAALVERVWGDDLRVEGVVVESLDGVDDLPALVAAFQPGPRRRLGVLVDHLVAGSKESRIAASVTSPYVLVTGHPYVDIWQAVKPSSVGIAAWPQVPRGQPWKEGVCRALGVAEPADMWRRVLGSVRSYTDVEAGLLGAVERLIDFVTVPAGDVDDEHGAKHGAEYGEGHDRGHESGRA
>NC_015656.1|WP_043606273.1|3050816_3051419_+|isochorismatase-family-protein
MTDEYGPGVALLVIDVQNDFAAPTGSLYVAGGEEIIPPVNDEIERAVAAGSPVVYTQDWHPPTTPHFVTGGGIWPPHCVRETEGAQLHPALRVDGTIVRKGTGGEDGYSGFTVRNPLTDADQATELVDVLTAREVRRIVVVGLAGDHCVKATALDGRALGFDVVVPLALTRFVGLRPGDEKQAVSQMREAGVRVLTRPSK

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_015656_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015656_10

3841895-3842167

Orphan

Consensus_repeat	Method
CGGCAGTCCCGCGCGCACGCGCGGCATGCAGCACG	PILER-CR
TCCCGCGCGCACGCGCGGCATGC	CRISPRCasFinder
CCCGCGCGCANGCGCGGCATGC	CRT

4 spacers

The CRISPR arrays of NC_015656_10

>merge|NC_015656|10|3841895-3842167|PILER-CR,CRISPRCasFinder,CRT
GGCAATCCCGCGCGCACGCGCGGCATGCTGGAGGAGTGGGCGTGGCGTACCAACCGCAAGCGGCAGTCCCGCGCGCACGCGCAGCATGCGCCAGCATCACCTACACCGCCGTCACCGGCCTCGGCAGTCCCGCGCGCACGCGCGGCATGCAGCGCGCACAGCCACGGATCCCACGGTTCCCGGGGCAGTCCCCGCGCGCATGCGTGGCATGCGTCACCGTGGGCCGGCTCGCCGCCGCCAAGGCGCCGTCCCCTGCGCGCATGCGCGGCAAGC

>NC_015656|10|1|3841895-3842050|PILER-CR
GGCAATCCCGCGCGCACGCGCGGCATGCTGGAGGA	GTGGGCGTGGCGTACCAACCGCAAGC
GGCAGTCCCGCGCGCACGCGCAGCATGCGCCAGCA	TCACCTACACCGCCGTCACCGGCCTCGGCAGT
CCCGCGCGCACGCGCGGCATGCAGCGCG

>NC_015656|10|10|3841900-3842167|CRISPRCasFinder
TCCCGCGCGCACGCGCGGCATGC	TGGAGGAGTGGGCGTGGCGTACCAACCGCAAGCGGCAG
TCCCGCGCGCACGCGCAGCATGC	GCCAGCATCACCTACACCGCCGTCACCGGCCTCGGCAG
TCCCGCGCGCACGCGCGGCATGC	AGCGCGCACAGCCACGGATCCCACGGTTCCCGGGGCAGT
CCCCGCGCGCATGCGTGGCATGC	GTCACCGTGGGCCGGCTCGCCGCCGCCAAGGCGCCGTC
CCCTGCGCGCATGCGCGGCAAGC

>NC_015656|10|1|3841901-3842167|CRT
CCCGCGCGCACGCGCGGCATGC	TGGAGGAGTGGGCGTGGCGTACCAACCGCAAGCGGCAGT
CCCGCGCGCACGCGCAGCATGC	GCCAGCATCACCTACACCGCCGTCACCGGCCTCGGCAGT
CCCGCGCGCACGCGCGGCATGC	AGCGCGCACAGCCACGGATCCCACGGTTCCCGGGGCAGTC
CCCGCGCGCATGCGTGGCATGC	GTCACCGTGGGCCGGCTCGCCGCCGCCAAGGCGCCGTCC
CCTGCGCGCATGCGCGGCAAGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015656.1\|WP_013874442.1\|3844663_3844882_+\|hypothetical-protein	unknown	unknown	unknown
NC_015656.1\|WP_013874436.1\|3833293_3835144_+\|NAD+-synthase	unknown	unknown	gnl\|CDD\|237577
NC_015656.1\|WP_013874433.1\|3829181_3830831_-\|hypothetical-protein	unknown	unknown	unknown
NC_015656.1\|WP_043603806.1\|3852368_3852584_-\|hypothetical-protein	unknown	unknown	unknown
NC_015656.1\|WP_013874435.1\|3831669_3833028_-\|type-I-glutamate--ammonia-ligase	unknown	unknown	gnl\|CDD\|223252
NC_015656.1\|WP_013874440.1\|3842465_3843266_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238564
NC_015656.1\|WP_131772698.1\|3846688_3848047_+\|PKD-domain-containing-protein	unknown	unknown	gnl\|CDD\|238084
NC_015656.1\|WP_131774046.1\|3835361_3836084_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379883
NC_015656.1\|WP_013874448.1\|3851230_3851848_-\|malonic-semialdehyde-reductase	unknown	unknown	gnl\|CDD\|180040
NC_015656.1\|WP_165001443.1\|3848992_3850747_-\|CTP-synthase	unknown	unknown	gnl\|CDD\|235437
NC_015656.1\|WP_193353072.1\|3837916_3838489_-\|hypothetical-protein	unknown	unknown	unknown
NC_015656.1\|WP_013874446.1\|3848135_3849011_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|239516
NC_015656.1\|WP_013874431.1\|3824804_3825866_+\|glutamine-synthetase-beta-grasp-domain-containing-protein	unknown	unknown	gnl\|CDD\|177922
NC_015656.1\|WP_013874434.1\|3830923_3831106_-\|hypothetical-protein	unknown	unknown	unknown
NC_015656.1\|WP_013874441.1\|3843393_3844077_-\|NADPH-dependent-F420-reductase	unknown	unknown	gnl\|CDD\|273873
NC_015656.1\|WP_050803563.1\|3845014_3846019_-\|site-specific-tyrosine-recombinase-XerD	unknown	unknown	gnl\|CDD\|234713
NC_015656.1\|WP_157491033.1\|3846021_3846159_-\|hypothetical-protein	unknown	unknown	unknown
NC_015656.1\|WP_131774045.1\|3825940_3829021_-\|bifunctional-[glutamine-synthetase]-adenylyltransferase/[glutamine-synthetase]-adenylyl-L-tyrosine-phosphorylase	unknown	unknown	gnl\|CDD\|237613
NC_015656.1\|WP_085948540.1\|3840427_3841605_+\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|222853
NC_015656.1\|WP_013874438.1\|3836613_3837552_+\|3-methyl-2-oxobutanoate-hydroxymethyltransferase	unknown	unknown	gnl\|CDD\|234723

Protein	Function_ID	Function_description	E-value
NC_015656.1\|WP_013874436.1\|3833293_3835144_+\|NAD+-synthase	gnl\|CDD\|237577	PRK13981, PRK13981, NAD synthetase; Provisional.	0
NC_015656.1\|WP_013874435.1\|3831669_3833028_-\|type-I-glutamate--ammonia-ligase	gnl\|CDD\|223252	COG0174, GlnA, Glutamine synthetase [Amino acid transport and metabolism].	0
NC_015656.1\|WP_013874440.1\|3842465_3843266_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|238564	cd01144, BtuF, Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind the metal ion in the cleft between these domains. In addition, these proteins sometimes have a low complexity region containing a metal-binding histidine-rich motif (repetitive HDH sequence).	3.25751e-44
NC_015656.1\|WP_131772698.1\|3846688_3848047_+\|PKD-domain-containing-protein	gnl\|CDD\|238084	cd00146, PKD, polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.	1.94403e-05
NC_015656.1\|WP_131774046.1\|3835361_3836084_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|379883	pfam16859, TetR_C_11, Bacterial transcriptional repressor C-terminal. This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. Another target protein is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli.	1.19091e-19
NC_015656.1\|WP_013874448.1\|3851230_3851848_-\|malonic-semialdehyde-reductase	gnl\|CDD\|180040	PRK05365, PRK05365, malonic semialdehyde reductase; Provisional.	1.93365e-97
NC_015656.1\|WP_165001443.1\|3848992_3850747_-\|CTP-synthase	gnl\|CDD\|235437	PRK05380, pyrG, CTP synthetase; Validated.	0
NC_015656.1\|WP_013874446.1\|3848135_3849011_-\|NUDIX-hydrolase	gnl\|CDD\|239516	cd03424, ADPRase_NUDT5, ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+, for its activity. It also contains a highly conserved 23-residue Nudix motif (GX5EX7REUXEEXGU, where U = I, L or V) which functions as a metal binding site/catalytic site. In addition to the Nudix motif, there are additional conserved amino acid residues, distal from the signature sequence, that correlate with substrate specificity. In humans, there are four distinct ADPRase activities, three putative cytosolic enzymes (ADPRase-I, -II, and -Mn) and a single mitochondrial enzyme (ADPRase-m). Human ADPRase-II is also referred to as NUDT5. It lacks the N-terminal target sequence unique to mitochondrial ADPRase. The different cytosolic types are distinguished by their specificities for substrate and specific requirement for metal ions. NUDT5 forms a homodimer.	3.18253e-43
NC_015656.1\|WP_013874431.1\|3824804_3825866_+\|glutamine-synthetase-beta-grasp-domain-containing-protein	gnl\|CDD\|177922	PLN02284, PLN02284, glutamine synthetase.	3.34233e-155
NC_015656.1\|WP_013874441.1\|3843393_3844077_-\|NADPH-dependent-F420-reductase	gnl\|CDD\|273873	TIGR01915, F420-dependent_NADP_reductase, NADPH-dependent F420 reductase. This model represents a subset of a parent family described by pfam03807. Unlike the parent family, members of this family are found only in species with evidence of coenzyme F420. All members of this family are believed to act as NADPH-dependent F420 reductase. [Energy metabolism, Electron transport].	1.16733e-70
NC_015656.1\|WP_050803563.1\|3845014_3846019_-\|site-specific-tyrosine-recombinase-XerD	gnl\|CDD\|234713	PRK00283, xerD, tyrosine recombinase.	5.05135e-136
NC_015656.1\|WP_131774045.1\|3825940_3829021_-\|bifunctional-[glutamine-synthetase]-adenylyltransferase/[glutamine-synthetase]-adenylyl-L-tyrosine-phosphorylase	gnl\|CDD\|237613	PRK14109, PRK14109, bifunctional [glutamine synthetase] adenylyltransferase/[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase.	0
NC_015656.1\|WP_085948540.1\|3840427_3841605_+\|IS3-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	5.13982e-69
NC_015656.1\|WP_013874438.1\|3836613_3837552_+\|3-methyl-2-oxobutanoate-hydroxymethyltransferase	gnl\|CDD\|234723	PRK00311, panB, 3-methyl-2-oxobutanoate hydroxymethyltransferase; Reviewed.	9.38008e-157

>NC_015656.1|WP_085948540.1|3840427_3841605_+|IS3-family-transposase
MTESRRRFTPEYKDEAVKLVIDSGRPVSAIAKDLGINEGTLGSWVATWRRAHQGEEEPLSMSERARLRELEKENRELRMEREFLSKAGSLLRATPSVIDKFELIAAEKDNYPIRKMCQWLVVSTSGFYDWYQRPVSSRTRRHTTLDTQVRALFAASRQTYGARRIAAALTASGQPTSVRLARRIMRRAGLKACQPRAYRRTTIPGQAPVPTDHVRRDFTATRPGAKLVGDITYVRTGEGWLYLATVIDCYSRKVLGWSMASHMRTELVVDAFTMAASRTTLAPNAVFHSDRGTQYTSDAYHRTLARHGVRPSVGATGVCWDNSAAESFFGTLKNELVYREIYLTRRAARSAIAEYIEVFYNRQRLHSTLGYHTPEHVERLYLTSRTSIPEAA
>NC_015656.1|WP_193353072.1|3837916_3838489_-|hypothetical-protein
MDAASWAARDDDARAVLAASVQQRLVTVSDLWDVAHRRGRIWRRRLIIDTLADLDVGAESVAEMLYRRIECRYGLPSSHCQFKVDLGGRRYLDVWYEPWRVWVEIDGAAHQEVRQWWDDLARQNLGVLQDRLILRFPTWRLRERPDLVAAQVTDALRQRGWDGDRRQRTPASHIGPGGDNTGPNDVNAVL
>NC_015656.1|WP_013874438.1|3836613_3837552_+|3-methyl-2-oxobutanoate-hydroxymethyltransferase
MNRTAEVCSASPAAAAGEATTLYGASTAPGTPAAGSGPAAAARGGAARRGRTTVRELQAAKDRGEKWAMLTAYDATTARIFDDVGVPVLLVGDSAANVVYGYETTVPVTVEEMLPLVRAVVRGTTHALVVADLPFGSYQRSVEQAIDNAARFMKDGGAQAVKLEGGARVVPQVAALVAAGIPVMAHLGLTPQSVNVLGGYRVQGRGHAGDALLADALALEAAGAFAVVLEVVPSDLAARVSKELTIPVVGIGAGPDCDAQVLVWQDMAGLSDAHARFVKHYADLRSTLADAALRFTEEVRGGTFPTVEHSYH
>NC_015656.1|WP_131774046.1|3835361_3836084_-|TetR/AcrR-family-transcriptional-regulator
MSSGRASGPARSAASEQHHPPADRRGPGPARPAQPPMRTPGRPRDTRRDEAIISATLHTLADYGFAGLSMEAVAARAGVGKATVYRRWPTKDALVVEALGTLADLSGGAQTGSLRDDLVAWLNTVRKHSIQTLAGRIMPRLLAEKEEHPDLFEAYRRRVMAPARDRVAALLRGGIVSGELSPDIDIEMIIDMLIGSVAYWQYAGHSRDVTGSRITGVVDTVLRGILQCSGSDTAGMPAAG
>NC_015656.1|WP_013874436.1|3833293_3835144_+|NAD+-synthase
MTQLRVALAQVDTTVGDLAANADLVSAWAGRAVRAGAHLVAFPEMTLTGYPAEDLVLRRSFAQASRAAVDRLARRLADEGAGELAVVVGYLDSSRNPTPRLGRPAGEPQNAAAVLWRGEVAARYAKHHLPNYGVFDEFRYFVPGYDFPVLRLHGVDVGLTICEDLWQDGGPVAVARAAAVGLLVCINGSPYERGKAFQRDELAAARAREAGAALAYVNLVGGQDELVFDGGSLVVDADGRTLARAEQFTETLLTVDLDLPAGALVAGAPVAGPVVTGPVDAGDGTTIAVSRVVLADEPVSPFEAREPTVAQRLDSAAELYAAVVTGTRDYVRKNGFASVVLGLSGGIDSALVATIAVDALGAARVHTVAMPSVHSSAGSVADAAELARRTGVTHTVVPIQPVVDAFHDALAGTGGLAGLAAENLQARVRGTLLMALSNAHGHLVLTTGNKSELATGFSTLYGDSAGGFAPIKDVPKTLVWELARWRNAQAPRDGEAPPIPEEIIVKPPSAELAPGQLDSDRLPDYSTLDAVLDDYVERDQGRTELITAGHDPDTVERVIRLADLAEYKRRQNPPGPKVTSKAFGRDRRLPITSHWRERTGSPPAVEPSPRPDSVTP
>NC_015656.1|WP_013874435.1|3831669_3833028_-|type-I-glutamate--ammonia-ligase
MDKQQEFVLRTLEERDIRFIRLWFTDVLGVLKSVEIAPAELEGALAEGIGFDGSSIEGFARVHEADMLVKPDPSTFQVLPWRGDSPVTARMFCDLVMPGGAPSPADSRWVLRRTLATAAEAGFTFYTHPEIEFFLLRQPPQRGAPVPPPVDDSGYFDLTPNDISHDFRQQAIGVLERLGISVEFSHHEVAPGQQEIDLRYADALTIADNIMTFRQVVKEVALRQGVYATFMPKPYSDQAGSGMHTHLSLFEGDRNAFYDPTDPYHLSKVAQAFIAGLLVHAAEITAVTNQWVNSYKRIVGDQRAGEVLEAPAYVCWGHNNRSALVRIPLHKPNKPNATRIEFRSPDSACNPYLAFALILAAGLRGIQEGYELPPPAADDVWTLTEPQRNERGIRALPGTLEEAIATMERSEMVRDTLGADLFEFFLRNKRAEWAEYRRQVTPFEIDRYLPIL
>NC_015656.1|WP_013874434.1|3830923_3831106_-|hypothetical-protein
MTTTTGLDAAELAAEHAELLPERSAMAVWDYTDLGWSGGFFGGLFAVTADFVGGAFFVQL
>NC_015656.1|WP_013874433.1|3829181_3830831_-|hypothetical-protein
MTAQPAAADAPAVADTLVATAETAAADTLVATAVSAVAGAAVATTAPAVAVPQRPVAAGGLRMLGEFTGSGLRGQVFLARRRDGQVITLTGLLRHIVDAADGSRDIPAIARRVRAVSGRAVSADDVVYLLATKLIPLGVIADGHGATATPRATPLLGLAGRRTLVPEPAVDTLARLLAPLFRPVVVTGVLAALVIVDAWLFTSLFTSAGAGTGIGADSGVDARIHHVLASPALILTVLGGTLASMIFHECGHAAACHYGGGRPGVIGCGIYLLWPALYTDVTDAYRLDRAGRLRTDLGGVYFNAIVIVGLGTAYAISGADTLAVIVLLVHLEAFQQLVPVVRLDGYYILSDLAGVPDLFARIGPVLSTRLYQARERCRRWAHTEGGRHRRRGRHHDRIRSLTRGRARSQSRQRGSGQAPDPRVAALTHRAQRTITVWVLVVAPLLATNLVLIIMIAPSVVARCVDAVRDRAGLVAHAAGAGQPAAMIADALGVVVLVLPAVGIVFLLSRLAGAGVRAAVAIGRGGPGRALAAGLGMIVVIGAVLTSWLR
>NC_015656.1|WP_131774045.1|3825940_3829021_-|bifunctional-[glutamine-synthetase]-adenylyltransferase/[glutamine-synthetase]-adenylyl-L-tyrosine-phosphorylase
MGFTNVDRFAVTVRRLGLVDHDDERPSGAAGAAGAATPSGDLYDNALLAELARAANPDLALAALERIVETAPADVGRDLLTVLGTRPGLRTRLVAVLGASAALGDHLVRHPTDWRVLADDDLMRTPPDADLTRARLLRAVGAGPDMPLPRAAGDSTEVLDALRVAYRRSLMILAARDLTGAVSLDDATAELADLAAAALDAALAVARSALSPSAPPARLAVVGMGKCGGRELNYVSDVDVLFVAEPGDDGRPATTSAARTAALGTATSLAVGMVRACGAVTGEGTLFQVDVGLRPEGRDGPLVRTLASHDAYYRRWARTWEFQALLKARPIAGDREVGEQLCAAVRPLVWSAASRPGFVADVRAMRRRVERSLPRADADRDLKLGPGGLRDVEFAVQLLQLVHGRADPTLRAVSTLPALDALARGGYVGRRDAAGLADAYRFLRGTEHRLQLQRLRRVHTLPRDPAEMRWLARSLGFATAERMEAEHARVARFVRRLHERLFYQPLLEAVARLSAEEVRLTPAEARDRLAALGFADTGRALRHIEALTSGVSRTATIQRRLLPAMLHWFADAADPDAGLLAYRRVSEALGHTPWYLRLLRDEGGAAERLARLLAASTYVADLMQHAPESVRLLRTIDDLRPSGREQLVRVLIAIARRNPAREQAVGRARAVRRVELVRVACADLLGLLDVAAVGQALSDAAAATIEAALFVAQRRFEQETGRPLPVRIAVIAMGRLGGEELSYGSDADVVFVHEPVDDSRGSLTDSEVAAAAGSVVAELLRLLALPAGADPPLVLDAQLRPEGRAGPMTRTLASYAAYFNRWSQGWEAQALLRARPVAGDAALGERFCAWVDGIRYPPALRPGVVAELVRLRGRMEAERIPSGVDHTLHLKLGPGGLADVEWAVQVLQLRHAHRVPALRTTSTLAGLRAAVSAGLLDPAEAATLTQAWTTASRIRNAIMLARGRPGDVLPRQPRALAQVAGALGRPADQTETLMGDYRRGGAHARAVVEAVFARELDNGYPAGADG
>NC_015656.1|WP_013874431.1|3824804_3825866_+|glutamine-synthetase-beta-grasp-domain-containing-protein
MSYQAEYIWIDGTRPEPLMRSKTRIVADGKEPDIWGFDGSSTNQAPGSNSDCVLRPVFTCPDPLRGGKNVLVLCEVELTDFTPHPTNTRAFCRQAYEKYADQQPLFGIEQEYTFFQQGRPLGWPEVGYPAPQGPYYCGVGGEKMVGRAIVERHTQACLDAGLAIEGTNAEVMMAQWEFQIGVLPPPAIGDQIWVGRWLLHRIAEDFDVTVSFAAKPIPGDWNGAGAHTNFSTRATMESWDAIVTVCEALGTRVLEHVKNYGDGIEQRLTGQHETAPYDRFSWGASDRGASVRIPWAVEKAKKGWIEDRRPNANMDPYLVTGLIVDTCCSALAGTRPSLAIPGQKESLNAVVTV
>NC_015656.1|WP_013874440.1|3842465_3843266_-|ABC-transporter-substrate-binding-protein
MTAASGRDDPGIDDLGNGVTVPRQVTRVVSLVPSLTEAIAHTAPGLLVGATAWCSRPVDLDVARVRGTKNPDITTIVSLAPDVVCANAEENREVDLDQLRAAGIPVWVTAPATVDAALVSLERMLRDACRLDRPEWLTAARATWAAPYRGPRRSALVPVWRRPWMAVGRETFTGDVLRRLGIDNVLADHAQRYPRIRLDEVQPVDLVVLPDEPYPFSPADGPEAFGDTPVVCVSGRHLTWYGPSLVSARAVLDAQLSHPVTTPART
>NC_015656.1|WP_013874441.1|3843393_3844077_-|NADPH-dependent-F420-reductase
MGSPGDLPDVSLLTISILGGTGPQGRGLGRRLAIAGNRVVLGSRSAERAGKAAAKLGAAGWAVTGADNATAAAAGDIVIVAVPWDGHGELLTGLRAELAGKIVVDCVNPLGFDRGGAFVLPVPEGSAAQQAAALLPESTVVAAFHHVSAVLLEDETVNEIDTDVLVLGDDRQATDTVTALAGRIAGIRGIYAGKLRNAASVEGLTANLISVNRRYKSHAGLRVTDVQ
>NC_015656.1|WP_013874442.1|3844663_3844882_+|hypothetical-protein
MADVSVRFAMTNDSEVVLNLSLPQALRLMEAIARKVGETLAERSTQGVGGVGGVPTPAPSNGMPSLGPYTPS
>NC_015656.1|WP_050803563.1|3845014_3846019_-|site-specific-tyrosine-recombinase-XerD
MPADPEPEPEPVAGDPAVVVERFLDHLAGERGLARNSVLAYRRDLRRYLEHLSLRGVRSLADVDESEVAEFAATLREGAGEHPPLAASSVARMLVSVRSLHRFAAREGEVTSDVSRPVRPPTPPRRLPRALTVDQVVAVLRAASTSAAGGPGGDPAEGSRQLRAVALLELLYGTGARISEAVGLDVDDLDLDAASVRLLGKGGRARVVPLGRYAGEALAAYLVRARPVLASRRASPAVFLSRRGTRLSRQSAWTVLRTAAVAAGVEGVSPHVLRHSFATHLLDGGADVRVVQELLGHASVSTTQIYTLVTVDRLREVYATSHPRALGTSRPAQG
>NC_015656.1|WP_157491033.1|3846021_3846159_-|hypothetical-protein
MAGESVVASGGDRAVPGGDRRPPAAAAAHRARAVRTVRTVRTVRT
>NC_015656.1|WP_131772698.1|3846688_3848047_+|PKD-domain-containing-protein
MPDVHARRRRHPRFPRPGWARRRGSARRRPGRHGSARGSDRHRADDRGDQSRPAARRRRQHRPDLSRPAGARRHCDAGAELGGLAHPERPVRHGVVVTRAAPSPHAHPRPRSRRPEGPGGHDQPGRGHAGGRNLLGRLGRDRHGWLRGRWTRRRHGTGQSYDTGQSYGHGAGAGRPLAIVLLVVTASLLGLLPPVVSPAAAAPDGRTGGACTALWGYCDTRATDSGYIYTFVGGRLHRTPATGAARRAGGGCGDCVVPLNYCNVGDETTDFEELLWATAPEAAADTNALCDPQPGAAPTLAQVQAALTNYLREQALPKPTLVVAPSGRSFANLPTVVYTPVPPAFVFNVDQPVLATITAVPHYRWDFGDGAIGPDSPGRPFDPAISPREHPDAYVSHPYRQPGTYTITLTVTWQGTFAVPGVGQAFPLDPVVLAANAPVVVDEAGSVLTGND
>NC_015656.1|WP_013874446.1|3848135_3849011_-|NUDIX-hydrolase
MATRNVTTGNAAGGAQAGGATAGGVGEPDARGPDGARADSAPAAGPQTDNTPPAESSAAPTNGAPVDGGPAAGTPAAEAGYRSDSGHRYEVVESDVVFTGRIIRLRRDIVRMPDGGVSQRDVIMHPGAVGVVALDESGRVVMVNQYRHPVRRPLWELPAGILDIPGEPLATAAARELAEEAHLTAARWDLLVDVLASPGMTDEAYRVFLARELAVIPPSQRHVGVHEEADMRTRRVDLDEAVADVLSGTITNAMAVIGILAAATARAGGFTSLRAADTPWPDRPTPGAPVS
>NC_015656.1|WP_165001443.1|3848992_3850747_-|CTP-synthase
MTRHIFVTGGVASSLGKGLTASSLGRLLKARGLRVTMQKLDPYLNVDPGTMNPFQHGEVFVTDDGAETDLDIGHYERFLDVDLDSSANVTTGQVYSQVIARERRGGYLGQTVQVVPHITDEIKDRIRRLATDAWDVVITEVGGTVGDIESLPYLEAIRQVRHEVGRDNVLTVHVSLVPYLAPSGELKTKPTQHSVAALRSIGLQPDALVCRSDRPLPAALKSKIALMCDVDDEAVVGAPDAASIYDIPKVLHREGLDAYAVRRLGLPFRDVDWTEWDTLLRRVHRPANLVTVAIVGKYVDLPDAYLSVTEALRAGGFAVDARVEIRWVPADTCSSPQATAVALGGVDGVLVPGGFGIRGIEGKIEALRHARANGIPALGLCLGLQCMVIEAARNMAGLTDANSTEFDPQTPHPVISTMADQQAVVAGERDMGGTMRLGLYACTLAPGTVARRVYGAAEVDERHRHRYEVNNDYRDRLTAAGLVISGTSPDSRLVEVVELPVEVHPFYVGTQAHPEFRSRPTRAHPLFRALAAAAVTHSERRTGVLPVELPDGIADVDGQEMVDSQGIPGEVQCEELVPSWPPAT
>NC_015656.1|WP_013874448.1|3851230_3851848_-|malonic-semialdehyde-reductase
MTVTDASAGAALALDAAAADLLFHTAQTANTFSDEPVSDEQIRAIYDLVKWAPTSMNSQPLQIVLVRSPEARERLVAHLSPGNQAKTRSAPLAAIVAADVDFHDNLPQIFPHLPTARDIFAEPAFREHSARFNAALQIGYFILGIRAAGLAAGPMTGLDADAIDREFFADKPLRTLAVINIGRPGENAFRPRHPRLDYDQVISAL
>NC_015656.1|WP_043603806.1|3852368_3852584_-|hypothetical-protein
MIKHGDSVPEDLVPRADARTGPRRFSDAAARAGARRVHARQLREIIEEYERERGPLDIDGVQDALTEWPDI

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_015656_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015656_11

4510511-4510601

Orphan

Consensus_repeat	Method
CAGTTTCACTTGTGCCCTGAAGTCACCGGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015656_11

>merge|NC_015656|11|4510511-4510601|CRISPRCasFinder
CAGTTTCACTTGTGCCCTGAAGTCACCGGCCGCTACCTGAAGGATGCCGGTGGCTTCGGGCAGTTTCACTTGTGCCCTGAAGCCACCGGCC

>NC_015656|11|11|4510511-4510601|CRISPRCasFinder
CAGTTTCACTTGTGCCCTGAAGTCACCGGCC	GCTACCTGAAGGATGCCGGTGGCTTCGGG
CAGTTTCACTTGTGCCCTGAAGCCACCGGCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015656.1\|WP_013874993.1\|4504337_4504955_-\|hypothetical-protein	unknown	unknown	unknown
NC_015656.1\|WP_131772836.1\|4516531_4516702_-\|F0F1-ATPase-subunit-family-protein	unknown	unknown	unknown
NC_015656.1\|WP_013875002.1\|4513374_4514217_-\|F0F1-ATP-synthase-subunit-delta	unknown	unknown	gnl\|CDD\|237387
NC_015656.1\|WP_043603997.1\|4515136_4516018_-\|F0F1-ATP-synthase-subunit-A	unknown	unknown	gnl\|CDD\|235617
NC_015656.1\|WP_013874994.1\|4505103_4505448_-\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132914
NC_015656.1\|WP_013875009.1\|4518452_4519709_-\|serine-hydroxymethyltransferase	unknown	unknown	gnl\|CDD\|234571
NC_015656.1\|WP_013874992.1\|4502242_4504279_-\|protein-meaA	unknown	unknown	gnl\|CDD\|239653
NC_015656.1\|WP_013875003.1\|4514220_4514811_-\|F0F1-ATP-synthase-subunit-B	unknown	unknown	gnl\|CDD\|180240
NC_015656.1\|WP_043603998.1\|4517234_4518344_-\|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	unknown	unknown	gnl\|CDD\|133463
NC_015656.1\|WP_193353077.1\|4500631_4501132_-\|hypothetical-protein	unknown	unknown	unknown
NC_015656.1\|WP_013874998.1\|4508748_4509018_-\|F0F1-ATP-synthase-subunit-epsilon	unknown	unknown	gnl\|CDD\|184055
NC_015656.1\|WP_013875000.1\|4510744_4511641_-\|F0F1-ATP-synthase-subunit-gamma	unknown	unknown	gnl\|CDD\|235535
NC_015656.1\|WP_013874999.1\|4509059_4510502_-\|F0F1-ATP-synthase-subunit-beta	unknown	unknown	gnl\|CDD\|236447
NC_015656.1\|WP_013875007.1\|4516797_4517238_-\|hypothetical-protein	unknown	unknown	unknown
NC_015656.1\|WP_013875004.1\|4514826_4515072_-\|ATP-synthase-subunit-C	unknown	unknown	gnl\|CDD\|169138
NC_015656.1\|WP_083828354.1\|4506435_4507902_-\|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	unknown	unknown	gnl\|CDD\|236486
NC_015656.1\|WP_013874997.1\|4508082_4508655_+\|cob(I)yrinic-acid-a,c-diamide-adenosyltransferase	unknown	unknown	gnl\|CDD\|376665
NC_015656.1\|WP_013875001.1\|4511644_4513297_-\|F0F1-ATP-synthase-subunit-alpha	unknown	unknown	gnl\|CDD\|236448
NC_015656.1\|WP_131772835.1\|4506094_4506331_+\|hypothetical-protein	unknown	unknown	unknown
NC_015656.1\|WP_131792737.1\|4501409_4502090_-\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|213552

Protein	Function_ID	Function_description	E-value
NC_015656.1\|WP_043603998.1\|4517234_4518344_-\|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	gnl\|CDD\|133463	cd06853, GT_WecA_like, This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate molecule and N-acetylglucosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylglucosamine precursor. WecA participates in the biosynthesis of O antigen LPS in many enteric bacteria and is also involved in the biosynthesis of enterobacterial common antigen. A conserved short sequence motif and a conserved arginine at a cytosolic loop of this integral membrane protein were shown to be critical in recognition of substrate UDP-N-acetylglucosamine.	1.2093e-80
NC_015656.1\|WP_013875002.1\|4513374_4514217_-\|F0F1-ATP-synthase-subunit-delta	gnl\|CDD\|237387	PRK13430, PRK13430, F0F1 ATP synthase subunit delta; Provisional.	7.35634e-92
NC_015656.1\|WP_043603997.1\|4515136_4516018_-\|F0F1-ATP-synthase-subunit-A	gnl\|CDD\|235617	PRK05815, PRK05815, F0F1 ATP synthase subunit A; Validated.	2.45942e-57
NC_015656.1\|WP_013874994.1\|4505103_4505448_-\|STAS-domain-containing-protein	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	4.92507e-14
NC_015656.1\|WP_013874992.1\|4502242_4504279_-\|protein-meaA	gnl\|CDD\|239653	cd03681, MM_CoA_mutase_MeaA, Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, MeaA-like subfamily; contains various methylmalonyl coenzyme A (CoA) mutase (MCM)-like proteins similar to the Streptomyces cinnamonensis MeaA, Methylobacterium extorquens MeaA and Streptomyces collinus B12-dependent mutase. Members of this subfamily contain an N-terminal MCM domain and a C-terminal coenzyme B12 binding domain. S. cinnamonensis MeaA is a putative B12-dependent mutase which provides methylmalonyl-CoA precursors for the biosynthesis of the monensin polyketide via an unknown pathway. S. collinus B12-dependent mutase may be involved in a pathway for acetate assimilation.	0
NC_015656.1\|WP_013875003.1\|4514220_4514811_-\|F0F1-ATP-synthase-subunit-B	gnl\|CDD\|180240	PRK05759, PRK05759, F0F1 ATP synthase subunit B; Validated.	2.73787e-40
NC_015656.1\|WP_013874998.1\|4508748_4509018_-\|F0F1-ATP-synthase-subunit-epsilon	gnl\|CDD\|184055	PRK13442, atpC, F0F1 ATP synthase subunit epsilon; Provisional.	3.16119e-33
NC_015656.1\|WP_013875000.1\|4510744_4511641_-\|F0F1-ATP-synthase-subunit-gamma	gnl\|CDD\|235535	PRK05621, PRK05621, F0F1 ATP synthase subunit gamma; Validated.	2.75024e-148
NC_015656.1\|WP_013874999.1\|4509059_4510502_-\|F0F1-ATP-synthase-subunit-beta	gnl\|CDD\|236447	PRK09280, PRK09280, F0F1 ATP synthase subunit beta; Validated.	0
NC_015656.1\|WP_013875004.1\|4514826_4515072_-\|ATP-synthase-subunit-C	gnl\|CDD\|169138	PRK07874, PRK07874, ATP synthase F0 subunit C.	1.67149e-14
NC_015656.1\|WP_083828354.1\|4506435_4507902_-\|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	gnl\|CDD\|236486	PRK09369, PRK09369, UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated.	0
NC_015656.1\|WP_013874997.1\|4508082_4508655_+\|cob(I)yrinic-acid-a,c-diamide-adenosyltransferase	gnl\|CDD\|376665	pfam01923, Cob_adeno_trans, Cobalamin adenosyltransferase. Cobalamin adenosyltransferase This family contains the gene products of PduO and EutT which are both cobalamin adenosyltransferases. PduO is a protein with ATP:cob(I)alamin adenosyltransferase activity. The main role of this protein is the conversion of inactive cobalamins to AdoCbl for 1,2-propanediol degradation.The EutT enzyme appears to be an adenosyl transferase, converting CNB12 to AdoB12.	8.70944e-86
NC_015656.1\|WP_013875001.1\|4511644_4513297_-\|F0F1-ATP-synthase-subunit-alpha	gnl\|CDD\|236448	PRK09281, PRK09281, F0F1 ATP synthase subunit alpha; Validated.	0
NC_015656.1\|WP_013875009.1\|4518452_4519709_-\|serine-hydroxymethyltransferase	gnl\|CDD\|234571	PRK00011, glyA, serine hydroxymethyltransferase; Reviewed.	0
NC_015656.1\|WP_131792737.1\|4501409_4502090_-\|HD-domain-containing-protein	gnl\|CDD\|213552	TIGR00691, PppGpp_synthetase., (p)ppGpp synthetase, RelA/SpoT family. The functions of E. coli RelA and SpoT differ somewhat. RelA (EC 2.7.6.5) produces pppGpp (or ppGpp) from ATP and GTP (or GDP). SpoT (EC 3.1.7.2) degrades ppGpp, but may also act as a secondary ppGpp synthetase. The two proteins are strongly similar. In many species, a single homolog to SpoT and RelA appears reponsible for both ppGpp synthesis and ppGpp degradation. (p)ppGpp is a regulatory metabolite of the stringent response, but appears also to be involved in antibiotic biosynthesis in some species. [Cellular processes, Adaptations to atypical conditions].	4.53445e-11

>NC_015656.1|WP_013874999.1|4509059_4510502_-|F0F1-ATP-synthase-subunit-beta
MTVTTTSPAAAEGKAPGIGRVARVIGPVVDVEFAPEEIPEIYRALRVDRTINGQTATLTLEVAQHIGENTVRTISMQQTDGLVRGAPVQDTGSPITVPVGNATRGHVFNVLGEPLDVPSVDTDVRRSIHATAPAFDQLESKTEMFPTGIKVIDLLAPYVRGGKIGLFGGAGVGKTVVIQEMINRVAKQFSGVSVFAGVGERTREGNDLFLEMTEAGVINDTALVFGQMDEPPGTRLRIALAALTMAEYFRDVQKQDVLLFIDNIFRFTQAGSEVSTLLGRMPSAVGYQPTLADEMGVLQERITSTRGHSITSLQAIYVPADDITDPAPHTTFTHLDATTVLSRAISDLGIYPAVDPLDSSSRILDARYLGQEHYDVAREVQRILQRYKDLQDIIAILGIDELSEEDKILVNRARRIQRFLSQPFFVAEQFTGIPGTFVPLEETIKSFKKLTEGDYDHLPEQAFFMCGGIEDAEKKAKELL
>NC_015656.1|WP_013874998.1|4508748_4509018_-|F0F1-ATP-synthase-subunit-epsilon
MPIRVAIVSPEREVWSGDADMVIARTTEGEIGVLPRHVPLLGVLVQGGEVRIKIGSETLTVAVDGGFLSVTDQGVSILAEHATLSTPTT
>NC_015656.1|WP_013874997.1|4508082_4508655_+|cob(I)yrinic-acid-a,c-diamide-adenosyltransferase
MAIHLTRIYTRTGDDGTTALGDTSRVRKTDPRLAAYADVDETNATIGVALALGALSEDVRALLAQVQNDLFDLGADLCTPIVDSPSFPPLRVSQAYIDRLEEACDRYNERLPKLNSFILPGGSPGAALLHVSRTVARRAERSAWALLEDDPDRTSPLPVRYLNRLSDLLFILSRVANPGGDVLWQPGAGR
>NC_015656.1|WP_083828354.1|4506435_4507902_-|UDP-N-acetylglucosamine-1-carboxyvinyltransferase
MAVTGFSRWAETDGAFLASRPVGPAGDGRGGPAGCRSGLAVPVGRPRTAADKALPSTSVERFVATGGCQLVGGVDVPGAKNSVLKLMAASLLACGRTTLRSVPDILDVNVMADVLRALGASVERDVAEGSLSIDVPERPTAAADSDLVRRIRASVVVLGPLVARCGEARVALPGGDAIGARALDMHVSGLAKLGAVVDVESGILVARSSGRLQGASIWLDFPSVGATENLLMAGVLAKGTTVIDNAAREPEIADLCAMLVSMGARLDGAGTSTLVIEGVDELRPTTHDTVADRIVAGTFAIGALMTGGDVLVRGGRADHLEIVLDKLTTAGATVDTRPDGFRVRAERPPRSIDVVTLPYPGFPTDLLPQTIALEAVSEGVSLITENVFDSRFVFCRELSKLGADLRTDGHHVVVRRSDRLVGTHVAASDVRAGAGLVLAGLVAEGITSVSEVHHIDRGYAAFAEQLRLLGADIRREPRGGPDARRDDR
>NC_015656.1|WP_131772835.1|4506094_4506331_+|hypothetical-protein
MLVPVATLRTSSDADRLRQLLRQHGIRSTSGTAALGPIQVNADGKLRRHHTAAWHVMVFPEDSMRARAVVAGTERDWA
>NC_015656.1|WP_013874994.1|4505103_4505448_-|STAS-domain-containing-protein
MGKNVTFRNDGGRELQTVRLHGRVDVRTVGDLRLRLHTAIDCGRGRLRVNVAGLELADQAALGVLLGGVRRARRSGRSMVLVDVPDDLGRLLSANRLGRFLQVEDADLFHVGHA
>NC_015656.1|WP_013874993.1|4504337_4504955_-|hypothetical-protein
MLDVDAQRLNPADGPAYRAGGGQPTDPRRPLVIAGAFAAAIGLGAAIGLATAPTKTPAPRPAPTVAPPAEAQPPLEPSAWEGSRQPGAAHQMRVRLVDRRAFSASLAYALREGGIAGVATDDVVIPQGKLFYGAVEGVDSPADEYWAVGLAQVAGVTPAPPNPQVWKRTGNGPWQRIAQGPGACDGLPTGLFTVWQGRPPLCSGG
>NC_015656.1|WP_013874992.1|4502242_4504279_-|protein-meaA
MADAARQDLTEQARPQRDRPWIIRTYAGHSSPAETNALYRRNLAKGQTGLSVAFDLPTQTGYDPDHELARGEVGKVGVPIAHVGDMRALFHDIPLNRMNTSMTINATAMWLLALYQVVAQEQGADVAALTGTTQNDIIKEYLSRGTYVFPPAPSLRLITDMIAYTVTEIPRWNPINICSYHLQEAGATPVQEIAYSMCTAIAVLDAVVASGQVPAERTGEVCARISFFVNAGVRFVEELCKMRAFTRLWDTLLRTRYGVEDPRHRRFRYGVQVNSLGLTEAQPENNVIRIVLEALGVTLSKDARCRALQLPAWNEALGLPRPWDQQWSLRIQQILAHETDLLEYPDLFEGSVVVERRVAELAEAAQAEIDRVQAMGGAVAAVESGYMKSELVRSHATRRVRIESGEDVVVGVNAFTTTEPNPLLADLTTAIQTVDPAVEEAARTDIAAWRAGRDARAVDEALQNLRDTAKTDANLMPATLACARVGVTTGEWAGALREVFGEYRAPTGVSAASSVHAGGRQLSDVRERVVATGKELGRRLKFLVGKPGLDGHSNGAEQIAVRARDAGFEVVYQGIRLTPAQIVAAAVEEDVHVVGLSVLSGSHMELVPLVLDGLRAAGVGEVPVVVGGIIPPADAERLKALGVAEVYTPKDYGLTEIMDSVVDVIRVANGLGRSQPAS
>NC_015656.1|WP_131792737.1|4501409_4502090_-|HD-domain-containing-protein
MVSDTPSLDDAVALATRAHTGQLDKIGEGYIGHPLRVMRAVAAIADGVGADHEHAQMAAVLHDVVEDSAITLDDLVALGYPPAVVAAVDALSHRPGEPVEDYLARVAADDLAVAVKRADMADNGDPARLIRLPAERADRYRQRYADRTRLLDDLVAARRAAGKAAGTGEAAEAADADAHRKPAEEAGEASGTEGVGGTEGVGGGDAKRAGGRAAARGSGPPVASTP
>NC_015656.1|WP_193353077.1|4500631_4501132_-|hypothetical-protein
MAQAGVQILFAFLLTLPFTQRWNQVTDFQRALYLATLLLVAAASALLIGPVAYHRIMFRRGARARLVAAANTMALAGLVMLGAGINGAVLLVVDVLMGPLATVLICSATAAFFVALWWALPQLTRWELTAIHEDAQDSRPPAPGAPDAGAPDAGPPHPGPPGAGTR
>NC_015656.1|WP_013875000.1|4510744_4511641_-|F0F1-ATP-synthase-subunit-gamma
MAGQLREYRRRIRSVQSTKKITRAMELIAASRIVKAKARVAASRPYADEITRVISAVASQTTVRHPLTTEHPEARRAAVLVITSDRGLAGGYNANVLRRTGELLELLRAEGKEPVLYAVGRKAVTYYRFRGRELAGEFTGFSEQPGYDNAKEVADALIARFVESSEAAGVDEIHLVFTEYVNTLTQRPVAHRILPLVLEKTTEPPPGGPLPQYEFEPSAEGVLDALLPRYVESRLYASLLESAASESAARQRAMKSATDNAGELIKTYTRRANAARQDAITQEISEIVGGANALAQAS
>NC_015656.1|WP_013875001.1|4511644_4513297_-|F0F1-ATP-synthase-subunit-alpha
MTELSIRPEEIRAALRDYVDSYQASAGEREEVGRVVVAGDGIARVEGLPHAMTNELLEFHGGVLGLALNLDVGEIGCVLLGESEHIEEGQEVRRTGEILSVPVGDGFLGRVVDPLGRPIDGLGEIVSTESRALELQAPTVVQRQPVKEPLQTGIKAIDAMTAIGRGQRQLIIGDRQTGKSSVALDTIINQRENWATGDPKLQVKCVYVAIGQKKSTIRDVLNTLEETGALAYTTIVAAPADQPAGFKYLAPYTGSAIGQHWMYNGQHGLIVFDDLSKQAEAYRAISLLLRRPPGREAYPGDVFYLHSRLLERCAKLSDELGGGSLTGLPIIETKGNDISAYIPTNVISITDGQIFLETDLFNQGVRPAINVGTSVSRVGGSAQVKAMKSVAGRLRLDLAQYRELEAFSAFGSDLDKASRAQLDRGARLVELLKQPQFQPFSVEREVVSIWAGTTGHLDEVPIGDIRRFESEFLEFVERTQPGLFKTIRETGKLDDDTLAALEHLIAKFKTEFALSGGQPLINEPVPDTLDPAEVEQESIKVHQPKPRDED
>NC_015656.1|WP_013875002.1|4513374_4514217_-|F0F1-ATP-synthase-subunit-delta
MDGSSRRSLAVARARLDELTALPPPGTTTPRPAANLARLADDLDGVVDLLDRELVVRRALTDPGVPGSARSELAARLFGSKISPTALEIVQVAVTGRWARPLDLQQALAELAVEVLLAQAQRNNVLDDVEDELFRFGRLLNRTPELSLALSAPAAPVSAKQALVARLLDGKAHPVTVRLVQRAVTERYHGDLERRLEQLTTIAAARRNRLVAVVLSAVPLAGDQIYRLRTAISRYFGRDVQLQVDVDPAVLGGVVVRVGDEVVDGSVLRRLTDARRRLLR
>NC_015656.1|WP_013875003.1|4514220_4514811_-|F0F1-ATP-synthase-subunit-B
MAISTLLLAAEEGGGHSDENVLVPPVSELLIGILAFGLLVAFFFWKVYPQIRRTYAERSDRIEGNLARAERTQREAEDLLVSYRRQLAEAQDEAGRIRQDAREQGQQILDSLRAQAGEEVAEIKARGEAQLAAERAQVVAQIRREIGEIALELATKIVGHELQRDDRQRQLIDDFIAGLDRPADGTTVPAPAGPGG
>NC_015656.1|WP_013875004.1|4514826_4515072_-|ATP-synthase-subunit-C
MADTSLVLAAADQVSGSLGAVAYGLAAIGPGIGIGLIFGLGVQAIARQPEAEQVAFRYMIIGFALAEALALIGFVVPFVFP
>NC_015656.1|WP_043603997.1|4515136_4516018_-|F0F1-ATP-synthase-subunit-A
MEVYVVPVPPVLADEGFHGPTKEVFQTPHWFDVELGSVDFYLNKATALGIFAALVVGVVFWLGFRRATVVPRGVQNVCESIYDFIDTSIARDVIGEQGRKYTPYLVVLFTFVLVSNVLAIIPGAQFPPTSRIAIPIVLSAITYVLFNRAGIRAVGARAYFGHMVNPAPTAPFPVKLLLGPIELLSTLIVRPFTLAVRLFANMFAGHILLLVFSLGADYLLPKPPFVFGVASLLMTIVLTGFELVIDFLQAYIITILTAAFIGGALEEHGDEHDSSHSVDQVPAVSGASAAAHA
>NC_015656.1|WP_131772836.1|4516531_4516702_-|F0F1-ATPase-subunit-family-protein
MWSAFGTLLAGTGFWGLVGYGIDRVTGIGTVFLPVGVVVGMGAALYLVIYRAMRRQ
>NC_015656.1|WP_013875007.1|4516797_4517238_-|hypothetical-protein
MITAAGRTVRTGLLVLAAVAVPALPIAGFARGADGLAAVAAGLVLVALFFTASKVAVSVVARRMRAMVLPAALGTYLMKTIILGVLLVTLEGSDSVDLIAFSWAVLVGVLGWVGAELWVATHTRVPFYDPDAFRARGDSPHDTLNT
>NC_015656.1|WP_043603998.1|4517234_4518344_-|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase
MREYLLVFAVSAAITFLCTPVARCFAVRVGAVAGVRDRDVHAVPTPRLGGLAMLAGLAAGLLVADQLPFLSAVSEDWAEPHAVLIAGALICLLGVVDDRWPLDAVTKLAGQVVAAGVMVLLGIQWSFAVNPDSDTTFSLGPETAVPLSILATVILVNAMNFIDGLDGLAAGVAAIAAGSTFYFAYEVAVINHFSRAAPAALLAAVTAGVCVGFLPHNFNPARLFMGDSGSMLVGLLSAASMISVTGQVAYGGYAGPSRSLPSLIPLAIPLAVLAVPFIDLGLAVVRRTRAGRSPFAPDKMHLHHRMLEIGKSHVRAVLIMYFWAALLGFGGVAASFSRQPLPILAGVVGLGLAGLLVLLLAGQRSVRRA
>NC_015656.1|WP_013875009.1|4518452_4519709_-|serine-hydroxymethyltransferase
MSTPFWGPDFDQLHAEDPEIAGVLLDELDRLRGGLQLIASENFTSPAVLAALGSTLSNKYAEGYPGRRYYGGCQVVDRAEEIGIARAKELFGAEHANLQPHSGAQANFAVYAALLVPGDTVLAMSLPHGGHLTHGSRVNFSGKWFNVAAYGVREDNELIDYDEVRDLARQHQPKMIICGATAYPRLIDFAAFRSIADEVGAWLMVDAAHFIGLVAGGAIPSPVPYADVVSFTTHKVLRGPRGGMILCREELAQRIDKAVFPFSQGGPLMHAVAAKAVALREAATPAYQDYAQQVIRNAQALADALAAEGVRPVAGGTDTHLALLDLRALGVTGKEAEARCDAARITLNKNAIPYDPQPPAVSSGIRVGTPAVTTQGMKEGEMKDIAALIARVVSDPDAAADVAASVAALTARHPAYPR

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_015656_11	11.1\|4510542\|29\|NC_015656\|CRISPRCasFinder	4510542-4510570	29	NZ_CP050099	Rhizobium leguminosarum bv. trifolii strain 9B plasmid pRL9b5, complete sequence	331190-331218	5	0.828
NC_015656_11	11.1\|4510542\|29\|NC_015656\|CRISPRCasFinder	4510542-4510570	29	NZ_CP053441	Rhizobium leguminosarum bv. trifolii strain CC275e plasmid pRltCC275eE, complete sequence	357365-357393	5	0.828
NC_015656_11	11.1\|4510542\|29\|NC_015656\|CRISPRCasFinder	4510542-4510570	29	NZ_CP020909	Rhizobium etli strain NXC12 plasmid pRetNXC12c, complete sequence	431679-431707	5	0.828
NC_015656_11	11.1\|4510542\|29\|NC_015656\|CRISPRCasFinder	4510542-4510570	29	NZ_CP016289	Rhizobium leguminosarum strain Vaf10 plasmid unnamed2, complete sequence	532679-532707	6	0.793
NC_015656_11	11.1\|4510542\|29\|NC_015656\|CRISPRCasFinder	4510542-4510570	29	NZ_CP050093	Rhizobium leguminosarum bv. trifolii strain 22B plasmid pRL22b5, complete sequence	386318-386346	6	0.793
NC_015656_11	11.1\|4510542\|29\|NC_015656\|CRISPRCasFinder	4510542-4510570	29	NZ_CP050082	Rhizobium leguminosarum bv. trifolii strain 31B plasmid pRL31b4, complete sequence	582635-582663	6	0.793
NC_015656_11	11.1\|4510542\|29\|NC_015656\|CRISPRCasFinder	4510542-4510570	29	NZ_CP048282	Rhizobium leguminosarum bv. viciae 248 plasmid pRle248d, complete sequence	431536-431564	6	0.793
NC_015656_11	11.1\|4510542\|29\|NC_015656\|CRISPRCasFinder	4510542-4510570	29	NZ_CP054023	Rhizobium sp. JKLM12A2 plasmid pPR12A202, complete sequence	137816-137844	6	0.793
NC_015656_11	11.1\|4510542\|29\|NC_015656\|CRISPRCasFinder	4510542-4510570	29	NZ_CP054033	Rhizobium sp. JKLM13E plasmid pPR13E02, complete sequence	295100-295128	6	0.793
NC_015656_11	11.1\|4510542\|29\|NC_015656\|CRISPRCasFinder	4510542-4510570	29	NZ_CP053208	Rhizobium leguminosarum bv. trifolii TA1 plasmid pRltTA1B, complete sequence	480651-480679	6	0.793
NC_015656_11	11.1\|4510542\|29\|NC_015656\|CRISPRCasFinder	4510542-4510570	29	NC_011366	Rhizobium leguminosarum bv. trifolii WSM2304 plasmid pRLG202, complete sequence	66153-66181	6	0.793
NC_015656_11	11.1\|4510542\|29\|NC_015656\|CRISPRCasFinder	4510542-4510570	29	NZ_CP035001	Rhizobium acidisoli strain FH23 plasmid pRapFH23c, complete sequence	46778-46806	6	0.793
NC_015656_11	11.1\|4510542\|29\|NC_015656\|CRISPRCasFinder	4510542-4510570	29	MT708550	Achromobacter phage Mano, complete genome	7485-7513	6	0.793
NC_015656_11	11.1\|4510542\|29\|NC_015656\|CRISPRCasFinder	4510542-4510570	29	NZ_CP021028	Rhizobium sp. TAL182 plasmid pRetTAL182d, complete sequence	441785-441813	6	0.793
NC_015656_11	11.1\|4510542\|29\|NC_015656\|CRISPRCasFinder	4510542-4510570	29	NZ_CP013634	Rhizobium sp. N324 plasmid pRspN324d, complete sequence	373877-373905	6	0.793
NC_015656_11	11.1\|4510542\|29\|NC_015656\|CRISPRCasFinder	4510542-4510570	29	NZ_CP013577	Rhizobium phaseoli strain N671 plasmid pRphaN671c, complete sequence	333341-333369	6	0.793
NC_015656_11	11.1\|4510542\|29\|NC_015656\|CRISPRCasFinder	4510542-4510570	29	NZ_CP013549	Rhizobium phaseoli strain R611 plasmid pRetR611b, complete sequence	333711-333739	6	0.793
NC_015656_11	11.1\|4510542\|29\|NC_015656\|CRISPRCasFinder	4510542-4510570	29	NZ_CP013534	Rhizobium phaseoli strain R650 plasmid pRphaR650b, complete sequence	333711-333739	6	0.793
NC_015656_11	11.1\|4510542\|29\|NC_015656\|CRISPRCasFinder	4510542-4510570	29	NZ_CP013545	Rhizobium phaseoli strain R620 plasmid pRphaR620c, complete sequence	333703-333731	6	0.793
NC_015656_11	11.1\|4510542\|29\|NC_015656\|CRISPRCasFinder	4510542-4510570	29	NC_021908	Rhizobium etli bv. mimosae str. Mim1 plasmid pRetMIM1d, complete sequence	437723-437751	6	0.793
NC_015656_11	11.1\|4510542\|29\|NC_015656\|CRISPRCasFinder	4510542-4510570	29	NZ_CP013571	Rhizobium phaseoli strain N771 plasmid pRphaN771c, complete sequence	333341-333369	6	0.793
NC_015656_11	11.1\|4510542\|29\|NC_015656\|CRISPRCasFinder	4510542-4510570	29	NZ_CP013516	Rhizobium sp. N1314 plasmid pRspN1314e, complete sequence	443128-443156	6	0.793
NC_015656_11	11.1\|4510542\|29\|NC_015656\|CRISPRCasFinder	4510542-4510570	29	NZ_CP054029	Rhizobium sp. JKLM19E plasmid pPR19E02, complete sequence	195177-195205	6	0.793
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP010625	Phaeobacter inhibens strain P51 plasmid pP51_b, complete sequence	52543-52574	7	0.781
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP010670	Phaeobacter inhibens strain P57 plasmid pP57_b, complete sequence	52543-52574	7	0.781
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP010743	Phaeobacter inhibens strain P59 plasmid pP59_b, complete sequence	52529-52560	7	0.781
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP010620	Phaeobacter inhibens strain P30 isolate M4-3.1A plasmid pP30_c, complete sequence	56207-56238	7	0.781
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP010701	Phaeobacter inhibens strain P24 plasmid pP24_e, complete sequence	52543-52574	7	0.781
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP010747	Phaeobacter inhibens strain P48 isolate M21-2.3 plasmid pP48_b, complete sequence	52535-52566	7	0.781
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP032322	Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence	1641183-1641214	7	0.781
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP016083	Streptomyces sp. SAT1 plasmid unnamed3, complete sequence	490241-490272	7	0.781
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP050082	Rhizobium leguminosarum bv. trifolii strain 31B plasmid pRL31b4, complete sequence	55009-55040	7	0.781
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP050099	Rhizobium leguminosarum bv. trifolii strain 9B plasmid pRL9b5, complete sequence	39281-39312	7	0.781
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP025014	Rhizobium leguminosarum strain Norway plasmid pRLN2, complete sequence	38187-38218	7	0.781
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP049732	Rhizobium leguminosarum strain A1 plasmid pRL11, complete sequence	56180-56211	7	0.781
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP053441	Rhizobium leguminosarum bv. trifolii strain CC275e plasmid pRltCC275eE, complete sequence	39276-39307	7	0.781
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP048642	Streptomyces aureoverticillatus strain HN6 plasmid unnamed, complete sequence	78822-78853	7	0.781
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP025508	Rhizobium leguminosarum bv. viciae strain UPM791 plasmid pRlvB, complete sequence	41316-41347	7	0.781
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP007794	Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence	1406223-1406254	7	0.781
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NC_012858	Rhizobium leguminosarum bv. trifolii WSM1325 plasmid pR132502, complete sequence	553488-553519	7	0.781
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP030764	Rhizobium leguminosarum strain ATCC 14479 plasmid unnamed4, complete sequence	578064-578095	7	0.781
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NC_011892	Methylobacterium nodulans ORS 2060 plasmid pMNOD01, complete sequence	178489-178520	7	0.781
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP022667	Rhizobium leguminosarum bv. viciae strain BIHB 1217 plasmid pPR2, complete sequence	596337-596368	7	0.781
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP053208	Rhizobium leguminosarum bv. trifolii TA1 plasmid pRltTA1B, complete sequence	55283-55314	7	0.781
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP050087	Rhizobium leguminosarum bv. trifolii strain 23B plasmid pRL23b5, complete sequence	41315-41346	7	0.781
NC_015656_10	10.4\|3841984\|38\|NC_015656\|CRISPRCasFinder	3841984-3842021	38	NZ_CP010625	Phaeobacter inhibens strain P51 plasmid pP51_b, complete sequence	52543-52580	7	0.816
NC_015656_10	10.4\|3841984\|38\|NC_015656\|CRISPRCasFinder	3841984-3842021	38	NZ_CP010670	Phaeobacter inhibens strain P57 plasmid pP57_b, complete sequence	52543-52580	7	0.816
NC_015656_10	10.4\|3841984\|38\|NC_015656\|CRISPRCasFinder	3841984-3842021	38	NZ_CP010743	Phaeobacter inhibens strain P59 plasmid pP59_b, complete sequence	52529-52566	7	0.816
NC_015656_10	10.4\|3841984\|38\|NC_015656\|CRISPRCasFinder	3841984-3842021	38	NZ_CP010620	Phaeobacter inhibens strain P30 isolate M4-3.1A plasmid pP30_c, complete sequence	56207-56244	7	0.816
NC_015656_10	10.4\|3841984\|38\|NC_015656\|CRISPRCasFinder	3841984-3842021	38	NZ_CP010701	Phaeobacter inhibens strain P24 plasmid pP24_e, complete sequence	52543-52580	7	0.816
NC_015656_10	10.4\|3841984\|38\|NC_015656\|CRISPRCasFinder	3841984-3842021	38	NZ_CP010747	Phaeobacter inhibens strain P48 isolate M21-2.3 plasmid pP48_b, complete sequence	52535-52572	7	0.816
NC_015656_11	11.1\|4510542\|29\|NC_015656\|CRISPRCasFinder	4510542-4510570	29	NZ_CP007130	Gemmatirosa kalamazoonesis strain KBS708 plasmid 2, complete sequence	530998-531026	7	0.759
NC_015656_11	11.1\|4510542\|29\|NC_015656\|CRISPRCasFinder	4510542-4510570	29	NZ_CP006989	Rhizobium sp. IE4771 plasmid pRetIE4771c, complete sequence	401455-401483	7	0.759
NC_015656_11	11.1\|4510542\|29\|NC_015656\|CRISPRCasFinder	4510542-4510570	29	NZ_CP021126	Rhizobium sp. Kim5 plasmid pRetKim5b, complete sequence	412923-412951	7	0.759
NC_015656_11	11.1\|4510542\|29\|NC_015656\|CRISPRCasFinder	4510542-4510570	29	CP007642	Rhizobium etli bv. phaseoli str. IE4803 plasmid pRetIE4803a, complete sequence	378071-378099	7	0.759
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NC_022001	Streptomyces collinus Tu 365 plasmid pSCO1, complete sequence	62657-62688	8	0.75
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP015006	Aminobacter aminovorans strain KCTC 2477 plasmid pAA01, complete sequence	122961-122992	8	0.75
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NC_041973	Erwinia phage vB_EamM_RAY, complete genome	211846-211877	8	0.75
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	KU886223	Erwinia phage vB_EamM_Simmy50, complete genome	211723-211754	8	0.75
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP030074	Streptomyces sp. ZFG47 plasmid unnamed1, complete sequence	757607-757638	9	0.719
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP010898	Pandoraea vervacti strain NS15 plasmid pPV15, complete sequence	26133-26164	9	0.719
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NC_019848	Sinorhizobium meliloti GR4 plasmid pRmeGR4c, complete sequence	591154-591185	9	0.719
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NC_003037	Sinorhizobium meliloti 1021 plasmid pSymA, complete sequence	808697-808728	9	0.719
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP019585	Sinorhizobium meliloti strain CCMM B554 (FSM-MA) plasmid pSymA, complete sequence	847782-847813	9	0.719
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NC_017327	Sinorhizobium meliloti SM11 plasmid pSmeSM11c, complete sequence	772245-772276	9	0.719
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP021798	Sinorhizobium meliloti strain USDA1106 plasmid psymA, complete sequence	1272098-1272129	9	0.719
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NC_017324	Sinorhizobium meliloti BL225C plasmid pSINMEB01, complete sequence	1223283-1223314	9	0.719
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP009145	Sinorhizobium meliloti strain RMO17 plasmid pSymA, complete sequence	787805-787836	9	0.719
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP021827	Sinorhizobium meliloti strain KH35c plasmid psymA, complete sequence	887647-887678	9	0.719
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP021801	Sinorhizobium meliloti strain USDA1021 plasmid psymA, complete sequence	715748-715779	9	0.719
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP021830	Sinorhizobium meliloti strain HM006 plasmid psymA, complete sequence	208579-208610	9	0.719
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP021824	Sinorhizobium meliloti strain KH46 plasmid psymA, complete sequence	667166-667197	9	0.719
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP021813	Sinorhizobium meliloti strain M270 plasmid psymA, complete sequence	1197672-1197703	9	0.719
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NC_018683	Sinorhizobium meliloti Rm41 plasmid pSYMA, complete sequence	1017548-1017579	9	0.719
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP021794	Sinorhizobium meliloti strain USDA1157 plasmid psymA, complete sequence	1283047-1283078	9	0.719
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP021809	Sinorhizobium meliloti strain Rm41 plasmid psymA, complete sequence	1169630-1169661	9	0.719
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP021805	Sinorhizobium meliloti strain T073 plasmid psymA, complete sequence	1132829-1132860	9	0.719
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP010729	Phaeobacter inhibens strain P88 plasmid pP88_d, complete sequence	38907-38938	9	0.719
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP021217	Sinorhizobium meliloti RU11/001 plasmid pSymA, complete sequence	361974-362005	9	0.719
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP026526	Sinorhizobium meliloti strain AK21 plasmid pSymA, complete sequence	1098059-1098090	9	0.719
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP045361	Roseivivax sp. THAF40 plasmid pTHAF40_a, complete sequence	39830-39861	9	0.719
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP019483	Sinorhizobium meliloti strain B401 plasmid pSymA, complete sequence	687606-687637	9	0.719
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP045319	Roseivivax sp. THAF197b plasmid pTHAF197b_a, complete sequence	157930-157961	9	0.719
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP019486	Sinorhizobium meliloti strain B399 plasmid pSymA, complete sequence	655375-655406	9	0.719
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NC_020527	Sinorhizobium meliloti 2011 plasmid pSymA, complete sequence	808364-808395	9	0.719
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	KT160311	Vibrio phage H188, complete genome	19821-19852	9	0.719
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NC_007765	Rhizobium etli CFN 42 plasmid p42e, complete sequence	36012-36043	10	0.688
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP006989	Rhizobium sp. IE4771 plasmid pRetIE4771c, complete sequence	36103-36134	10	0.688
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP020909	Rhizobium etli strain NXC12 plasmid pRetNXC12c, complete sequence	36005-36036	10	0.688
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NC_021908	Rhizobium etli bv. mimosae str. Mim1 plasmid pRetMIM1d, complete sequence	35991-36022	10	0.688
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	NZ_CP021126	Rhizobium sp. Kim5 plasmid pRetKim5b, complete sequence	37246-37277	10	0.688
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	CP007642	Rhizobium etli bv. phaseoli str. IE4803 plasmid pRetIE4803a, complete sequence	36144-36175	10	0.688
NC_015656_10	10.2\|3841991\|32\|NC_015656\|PILER-CR	3841991-3842022	32	MG820641	Propionibacterium phage pa615, complete genome	17287-17318	10	0.688

1. spacer 11.1|4510542|29|NC_015656|CRISPRCasFinder matches to NZ_CP050099 (Rhizobium leguminosarum bv. trifolii strain 9B plasmid pRL9b5, complete sequence) position: , mismatch: 5, identity: 0.828

gctacctgaaggatgccggtggcttcggg	CRISPR spacer
ttgccctgaaggatgccggcggcttcggg	Protospacer
 .  ***************.*********

2. spacer 11.1|4510542|29|NC_015656|CRISPRCasFinder matches to NZ_CP053441 (Rhizobium leguminosarum bv. trifolii strain CC275e plasmid pRltCC275eE, complete sequence) position: , mismatch: 5, identity: 0.828

gctacctgaaggatgccggtggcttcggg	CRISPR spacer
ttgccctgaaggatgccggcggcttcggg	Protospacer
 .  ***************.*********

3. spacer 11.1|4510542|29|NC_015656|CRISPRCasFinder matches to NZ_CP020909 (Rhizobium etli strain NXC12 plasmid pRetNXC12c, complete sequence) position: , mismatch: 5, identity: 0.828

gctacctgaaggatgccggtggcttcggg	CRISPR spacer
tcatcctgaaggatgccggcggcttcggc	Protospacer
 *  ***************.********

4. spacer 11.1|4510542|29|NC_015656|CRISPRCasFinder matches to NZ_CP016289 (Rhizobium leguminosarum strain Vaf10 plasmid unnamed2, complete sequence) position: , mismatch: 6, identity: 0.793

gctacctgaaggatgccggtggcttcggg	CRISPR spacer
ttgccctgaaggatgccgccggcttcggg	Protospacer
 .  ************** .*********

5. spacer 11.1|4510542|29|NC_015656|CRISPRCasFinder matches to NZ_CP050093 (Rhizobium leguminosarum bv. trifolii strain 22B plasmid pRL22b5, complete sequence) position: , mismatch: 6, identity: 0.793

gctacctgaaggatgccggtggcttcggg	CRISPR spacer
ttgccctgaaggatgccgccggcttcggg	Protospacer
 .  ************** .*********

6. spacer 11.1|4510542|29|NC_015656|CRISPRCasFinder matches to NZ_CP050082 (Rhizobium leguminosarum bv. trifolii strain 31B plasmid pRL31b4, complete sequence) position: , mismatch: 6, identity: 0.793

gctacctgaaggatgccggtggcttcggg	CRISPR spacer
ttgccctgaaggatgccgccggcttcggg	Protospacer
 .  ************** .*********

7. spacer 11.1|4510542|29|NC_015656|CRISPRCasFinder matches to NZ_CP048282 (Rhizobium leguminosarum bv. viciae 248 plasmid pRle248d, complete sequence) position: , mismatch: 6, identity: 0.793

gctacctgaaggatgccggtggcttcggg	CRISPR spacer
ttgccctgaaggatgccgccggcttcggg	Protospacer
 .  ************** .*********

8. spacer 11.1|4510542|29|NC_015656|CRISPRCasFinder matches to NZ_CP054023 (Rhizobium sp. JKLM12A2 plasmid pPR12A202, complete sequence) position: , mismatch: 6, identity: 0.793

gctacctgaaggatgccggtggcttcggg	CRISPR spacer
ttgccctgaaggatgccgccggcttcggg	Protospacer
 .  ************** .*********

9. spacer 11.1|4510542|29|NC_015656|CRISPRCasFinder matches to NZ_CP054033 (Rhizobium sp. JKLM13E plasmid pPR13E02, complete sequence) position: , mismatch: 6, identity: 0.793

gctacctgaaggatgccggtggcttcggg	CRISPR spacer
ttgccctgaaggatgccgccggcttcggg	Protospacer
 .  ************** .*********

10. spacer 11.1|4510542|29|NC_015656|CRISPRCasFinder matches to NZ_CP053208 (Rhizobium leguminosarum bv. trifolii TA1 plasmid pRltTA1B, complete sequence) position: , mismatch: 6, identity: 0.793

gctacctgaaggatgccggtggcttcggg	CRISPR spacer
ttgtcctgaaggatgccgccggcttcggg	Protospacer
 .  ************** .*********

11. spacer 11.1|4510542|29|NC_015656|CRISPRCasFinder matches to NC_011366 (Rhizobium leguminosarum bv. trifolii WSM2304 plasmid pRLG202, complete sequence) position: , mismatch: 6, identity: 0.793

gctacctgaaggatgccggtggcttcggg	CRISPR spacer
tcgccctgaaggatgccgccggcttcggc	Protospacer
 *  ************** .********

12. spacer 11.1|4510542|29|NC_015656|CRISPRCasFinder matches to NZ_CP035001 (Rhizobium acidisoli strain FH23 plasmid pRapFH23c, complete sequence) position: , mismatch: 6, identity: 0.793

gctacctgaaggatgccggtggcttcggg	CRISPR spacer
tcaccctgaaggatgccgccggcttcggc	Protospacer
 *  ************** .********

13. spacer 11.1|4510542|29|NC_015656|CRISPRCasFinder matches to MT708550 (Achromobacter phage Mano, complete genome) position: , mismatch: 6, identity: 0.793

gctacctgaaggatgccggtggcttcggg	CRISPR spacer
tgcagctggatgatgccggtggcttcggg	Protospacer
  .* ***.* ******************

14. spacer 11.1|4510542|29|NC_015656|CRISPRCasFinder matches to NZ_CP021028 (Rhizobium sp. TAL182 plasmid pRetTAL182d, complete sequence) position: , mismatch: 6, identity: 0.793

gctacctgaaggatgccggtggcttcggg	CRISPR spacer
tcatcctgaaggatgccgccggcttcggc	Protospacer
 *  ************** .********

15. spacer 11.1|4510542|29|NC_015656|CRISPRCasFinder matches to NZ_CP013634 (Rhizobium sp. N324 plasmid pRspN324d, complete sequence) position: , mismatch: 6, identity: 0.793

gctacctgaaggatgccggtggcttcggg	CRISPR spacer
tcatcctgaaggatgccgccggcttcggt	Protospacer
 *  ************** .********

16. spacer 11.1|4510542|29|NC_015656|CRISPRCasFinder matches to NZ_CP013577 (Rhizobium phaseoli strain N671 plasmid pRphaN671c, complete sequence) position: , mismatch: 6, identity: 0.793

gctacctgaaggatgccggtggcttcggg	CRISPR spacer
tcatcctgaaggatgccgccggcttcggc	Protospacer
 *  ************** .********

17. spacer 11.1|4510542|29|NC_015656|CRISPRCasFinder matches to NZ_CP013549 (Rhizobium phaseoli strain R611 plasmid pRetR611b, complete sequence) position: , mismatch: 6, identity: 0.793

gctacctgaaggatgccggtggcttcggg	CRISPR spacer
tcatcctgaaggatgccgccggcttcggc	Protospacer
 *  ************** .********

18. spacer 11.1|4510542|29|NC_015656|CRISPRCasFinder matches to NZ_CP013534 (Rhizobium phaseoli strain R650 plasmid pRphaR650b, complete sequence) position: , mismatch: 6, identity: 0.793

gctacctgaaggatgccggtggcttcggg	CRISPR spacer
tcatcctgaaggatgccgccggcttcggc	Protospacer
 *  ************** .********

19. spacer 11.1|4510542|29|NC_015656|CRISPRCasFinder matches to NZ_CP013545 (Rhizobium phaseoli strain R620 plasmid pRphaR620c, complete sequence) position: , mismatch: 6, identity: 0.793

gctacctgaaggatgccggtggcttcggg	CRISPR spacer
tcatcctgaaggatgccgccggcttcggc	Protospacer
 *  ************** .********

20. spacer 11.1|4510542|29|NC_015656|CRISPRCasFinder matches to NC_021908 (Rhizobium etli bv. mimosae str. Mim1 plasmid pRetMIM1d, complete sequence) position: , mismatch: 6, identity: 0.793

gctacctgaaggatgccggtggcttcggg	CRISPR spacer
tcatcctgaaggatgccgccggcttcggc	Protospacer
 *  ************** .********

21. spacer 11.1|4510542|29|NC_015656|CRISPRCasFinder matches to NZ_CP013571 (Rhizobium phaseoli strain N771 plasmid pRphaN771c, complete sequence) position: , mismatch: 6, identity: 0.793

gctacctgaaggatgccggtggcttcggg	CRISPR spacer
tcatcctgaaggatgccgccggcttcggc	Protospacer
 *  ************** .********

22. spacer 11.1|4510542|29|NC_015656|CRISPRCasFinder matches to NZ_CP013516 (Rhizobium sp. N1314 plasmid pRspN1314e, complete sequence) position: , mismatch: 6, identity: 0.793

gctacctgaaggatgccggtggcttcggg	CRISPR spacer
tcctcctgaaggatgccgccggcttcggt	Protospacer
 *. ************** .********

23. spacer 11.1|4510542|29|NC_015656|CRISPRCasFinder matches to NZ_CP054029 (Rhizobium sp. JKLM19E plasmid pPR19E02, complete sequence) position: , mismatch: 6, identity: 0.793

gctacctgaaggatgccggtggcttcggg	CRISPR spacer
tcgtcctgaaggatgccgcgggcttcggt	Protospacer
 *  **************  ********

24. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP010625 (Phaeobacter inhibens strain P51 plasmid pP51_b, complete sequence) position: , mismatch: 7, identity: 0.781

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
cccagcatcaccaacaccgccatcaccgcagg	Protospacer
 *********** ********.******

25. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP010670 (Phaeobacter inhibens strain P57 plasmid pP57_b, complete sequence) position: , mismatch: 7, identity: 0.781

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
cccagcatcaccaacaccgccatcaccgcagg	Protospacer
 *********** ********.******

26. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP010743 (Phaeobacter inhibens strain P59 plasmid pP59_b, complete sequence) position: , mismatch: 7, identity: 0.781

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
cccagcatcaccaacaccgccatcaccgcagg	Protospacer
 *********** ********.******

27. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP010620 (Phaeobacter inhibens strain P30 isolate M4-3.1A plasmid pP30_c, complete sequence) position: , mismatch: 7, identity: 0.781

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
cccagcatcaccaacaccgccatcaccgcagg	Protospacer
 *********** ********.******

28. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP010701 (Phaeobacter inhibens strain P24 plasmid pP24_e, complete sequence) position: , mismatch: 7, identity: 0.781

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
cccagcatcaccaacaccgccatcaccgcagg	Protospacer
 *********** ********.******

29. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP010747 (Phaeobacter inhibens strain P48 isolate M21-2.3 plasmid pP48_b, complete sequence) position: , mismatch: 7, identity: 0.781

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
cccagcatcaccaacaccgccatcaccgcagg	Protospacer
 *********** ********.******

30. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP032322 (Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence) position: , mismatch: 7, identity: 0.781

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
gtgaccatcaccgacaccgccggcaccgtctt	Protospacer
*. * ******* ********* ***** *.*

31. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP016083 (Streptomyces sp. SAT1 plasmid unnamed3, complete sequence) position: , mismatch: 7, identity: 0.781

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
gcgcccatcaccaacaccgccgtctccgggat	Protospacer
**   ******* *********** ****  *

32. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP050082 (Rhizobium leguminosarum bv. trifolii strain 31B plasmid pRL31b4, complete sequence) position: , mismatch: 7, identity: 0.781

--gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
aggcc--catcaccagcaccgccgtcaccgccgg	Protospacer
  ***  ******* .************** *

33. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP050099 (Rhizobium leguminosarum bv. trifolii strain 9B plasmid pRL9b5, complete sequence) position: , mismatch: 7, identity: 0.781

--gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
aggcc--catcaccagcaccgccgtcaccgccgg	Protospacer
  ***  ******* .************** *

34. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP025014 (Rhizobium leguminosarum strain Norway plasmid pRLN2, complete sequence) position: , mismatch: 7, identity: 0.781

--gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
aggcc--catcaccagcaccgccgtcaccgccgg	Protospacer
  ***  ******* .************** *

35. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP049732 (Rhizobium leguminosarum strain A1 plasmid pRL11, complete sequence) position: , mismatch: 7, identity: 0.781

--gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
aggcc--catcaccagcaccgccgtcaccgccgg	Protospacer
  ***  ******* .************** *

36. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP053441 (Rhizobium leguminosarum bv. trifolii strain CC275e plasmid pRltCC275eE, complete sequence) position: , mismatch: 7, identity: 0.781

--gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
aggcc--catcaccagcaccgccgtcaccgccgg	Protospacer
  ***  ******* .************** *

37. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP048642 (Streptomyces aureoverticillatus strain HN6 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.781

-gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
gggcag-atcaccttcactgccgtcaccggggc	Protospacer
 * *** ******* ***.***********  .

38. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP025508 (Rhizobium leguminosarum bv. viciae strain UPM791 plasmid pRlvB, complete sequence) position: , mismatch: 7, identity: 0.781

--gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
aggcc--catcaccagcaccgccgtcaccgccgg	Protospacer
  ***  ******* .************** *

39. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP007794 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence) position: , mismatch: 7, identity: 0.781

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
gtgaccatcaccgacaccgccggcaccgtctt	Protospacer
*. * ******* ********* ***** *.*

40. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NC_012858 (Rhizobium leguminosarum bv. trifolii WSM1325 plasmid pR132502, complete sequence) position: , mismatch: 7, identity: 0.781

--gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
aggcc--catcaccagcaccgccgtcaccgccgg	Protospacer
  ***  ******* .************** *

41. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP030764 (Rhizobium leguminosarum strain ATCC 14479 plasmid unnamed4, complete sequence) position: , mismatch: 7, identity: 0.781

--gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
aggcc--catcaccagcaccgccgtcaccgccgg	Protospacer
  ***  ******* .************** *

42. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NC_011892 (Methylobacterium nodulans ORS 2060 plasmid pMNOD01, complete sequence) position: , mismatch: 7, identity: 0.781

gccagca-tcacctacaccgccgtcaccggcct	CRISPR spacer
-tcaccgctcacctacacctcggtcaccggcgt	Protospacer
 .** *. *********** * ********* *

43. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP022667 (Rhizobium leguminosarum bv. viciae strain BIHB 1217 plasmid pPR2, complete sequence) position: , mismatch: 7, identity: 0.781

--gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
aggcc--catcaccagcaccgccgtcaccgccgg	Protospacer
  ***  ******* .************** *

44. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP053208 (Rhizobium leguminosarum bv. trifolii TA1 plasmid pRltTA1B, complete sequence) position: , mismatch: 7, identity: 0.781

--gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
aggcc--catcaccagcaccgccgtcaccgccgg	Protospacer
  ***  ******* .************** *

45. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP050087 (Rhizobium leguminosarum bv. trifolii strain 23B plasmid pRL23b5, complete sequence) position: , mismatch: 7, identity: 0.781

--gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
aggcc--catcaccagcaccgccgtcaccgccgg	Protospacer
  ***  ******* .************** *

46. spacer 10.4|3841984|38|NC_015656|CRISPRCasFinder matches to NZ_CP010625 (Phaeobacter inhibens strain P51 plasmid pP51_b, complete sequence) position: , mismatch: 7, identity: 0.816

gccagcatcacctacaccgccgtcaccg--gcctcggcag	CRISPR spacer
cccagcatcaccaacaccgccatcaccgcaggcgcggc--	Protospacer
 *********** ********.******  * * ****

47. spacer 10.4|3841984|38|NC_015656|CRISPRCasFinder matches to NZ_CP010670 (Phaeobacter inhibens strain P57 plasmid pP57_b, complete sequence) position: , mismatch: 7, identity: 0.816

gccagcatcacctacaccgccgtcaccg--gcctcggcag	CRISPR spacer
cccagcatcaccaacaccgccatcaccgcaggcgcggc--	Protospacer
 *********** ********.******  * * ****

48. spacer 10.4|3841984|38|NC_015656|CRISPRCasFinder matches to NZ_CP010743 (Phaeobacter inhibens strain P59 plasmid pP59_b, complete sequence) position: , mismatch: 7, identity: 0.816

gccagcatcacctacaccgccgtcaccg--gcctcggcag	CRISPR spacer
cccagcatcaccaacaccgccatcaccgcaggcgcggc--	Protospacer
 *********** ********.******  * * ****

49. spacer 10.4|3841984|38|NC_015656|CRISPRCasFinder matches to NZ_CP010620 (Phaeobacter inhibens strain P30 isolate M4-3.1A plasmid pP30_c, complete sequence) position: , mismatch: 7, identity: 0.816

gccagcatcacctacaccgccgtcaccg--gcctcggcag	CRISPR spacer
cccagcatcaccaacaccgccatcaccgcaggcgcggc--	Protospacer
 *********** ********.******  * * ****

50. spacer 10.4|3841984|38|NC_015656|CRISPRCasFinder matches to NZ_CP010701 (Phaeobacter inhibens strain P24 plasmid pP24_e, complete sequence) position: , mismatch: 7, identity: 0.816

gccagcatcacctacaccgccgtcaccg--gcctcggcag	CRISPR spacer
cccagcatcaccaacaccgccatcaccgcaggcgcggc--	Protospacer
 *********** ********.******  * * ****

51. spacer 10.4|3841984|38|NC_015656|CRISPRCasFinder matches to NZ_CP010747 (Phaeobacter inhibens strain P48 isolate M21-2.3 plasmid pP48_b, complete sequence) position: , mismatch: 7, identity: 0.816

gccagcatcacctacaccgccgtcaccg--gcctcggcag	CRISPR spacer
cccagcatcaccaacaccgccatcaccgcaggcgcggc--	Protospacer
 *********** ********.******  * * ****

52. spacer 11.1|4510542|29|NC_015656|CRISPRCasFinder matches to NZ_CP007130 (Gemmatirosa kalamazoonesis strain KBS708 plasmid 2, complete sequence) position: , mismatch: 7, identity: 0.759

gctacctgaaggatgccggtggcttcggg	CRISPR spacer
tccgcctgaaggatcccggcggcttcgcc	Protospacer
 *..********** ****.*******

53. spacer 11.1|4510542|29|NC_015656|CRISPRCasFinder matches to NZ_CP006989 (Rhizobium sp. IE4771 plasmid pRetIE4771c, complete sequence) position: , mismatch: 7, identity: 0.759

gctacctgaaggatgccggtggcttcggg	CRISPR spacer
tcatgctgaaggatgccgccggcttcggc	Protospacer
 *   ************* .********

54. spacer 11.1|4510542|29|NC_015656|CRISPRCasFinder matches to NZ_CP021126 (Rhizobium sp. Kim5 plasmid pRetKim5b, complete sequence) position: , mismatch: 7, identity: 0.759

gctacctgaaggatgccggtggcttcggg	CRISPR spacer
tcatgctgaaggatgccgccggcttcggc	Protospacer
 *   ************* .********

55. spacer 11.1|4510542|29|NC_015656|CRISPRCasFinder matches to CP007642 (Rhizobium etli bv. phaseoli str. IE4803 plasmid pRetIE4803a, complete sequence) position: , mismatch: 7, identity: 0.759

gctacctgaaggatgccggtggcttcggg	CRISPR spacer
tcgtgctgaaggatgccgccggcttcggc	Protospacer
 *   ************* .********

56. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NC_022001 (Streptomyces collinus Tu 365 plasmid pSCO1, complete sequence) position: , mismatch: 8, identity: 0.75

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
acgtacggcaccggcaccgccgtcaccggcct	Protospacer
.*  .*. **** .******************

57. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP015006 (Aminobacter aminovorans strain KCTC 2477 plasmid pAA01, complete sequence) position: , mismatch: 8, identity: 0.75

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
atcgacttcacctcctccgccgtcaccggccg	Protospacer
..*..* ****** * ***************

58. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NC_041973 (Erwinia phage vB_EamM_RAY, complete genome) position: , mismatch: 8, identity: 0.75

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
gcctgcatcacctgcaccgccgtgcgcgcctg	Protospacer
*** *********.*********   ** *.

59. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to KU886223 (Erwinia phage vB_EamM_Simmy50, complete genome) position: , mismatch: 8, identity: 0.75

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
gcctgcatcacctgcaccgccgtgtgcgcctg	Protospacer
*** *********.*********   ** *.

60. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP030074 (Streptomyces sp. ZFG47 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.719

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
caggggtccacctacaccgccgtcgccggccg	Protospacer
   .*  .****************.******

61. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP010898 (Pandoraea vervacti strain NS15 plasmid pPV15, complete sequence) position: , mismatch: 9, identity: 0.719

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
cgtacattcaccgacagcgccgtcaccggcca	Protospacer
  .*   ***** *** **************

62. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NC_019848 (Sinorhizobium meliloti GR4 plasmid pRmeGR4c, complete sequence) position: , mismatch: 9, identity: 0.719

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
atccgcaacacctacaccgccatcaccaatgt	Protospacer
..* *** *************.*****... *

63. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NC_003037 (Sinorhizobium meliloti 1021 plasmid pSymA, complete sequence) position: , mismatch: 9, identity: 0.719

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
atccgcaacacctacaccgccatcaccaatgt	Protospacer
..* *** *************.*****... *

64. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP019585 (Sinorhizobium meliloti strain CCMM B554 (FSM-MA) plasmid pSymA, complete sequence) position: , mismatch: 9, identity: 0.719

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
atccgcaacacctacaccgccatcaccaatgt	Protospacer
..* *** *************.*****... *

65. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NC_017327 (Sinorhizobium meliloti SM11 plasmid pSmeSM11c, complete sequence) position: , mismatch: 9, identity: 0.719

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
atccgcaacacctacaccgccatcaccaatgt	Protospacer
..* *** *************.*****... *

66. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP021798 (Sinorhizobium meliloti strain USDA1106 plasmid psymA, complete sequence) position: , mismatch: 9, identity: 0.719

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
atccgcaacacctacaccgccatcaccaatgt	Protospacer
..* *** *************.*****... *

67. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NC_017324 (Sinorhizobium meliloti BL225C plasmid pSINMEB01, complete sequence) position: , mismatch: 9, identity: 0.719

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
atccgcaacacctacaccgccatcaccaatgt	Protospacer
..* *** *************.*****... *

68. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP009145 (Sinorhizobium meliloti strain RMO17 plasmid pSymA, complete sequence) position: , mismatch: 9, identity: 0.719

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
atccgcaacacctacaccgccatcaccaatgt	Protospacer
..* *** *************.*****... *

69. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP021827 (Sinorhizobium meliloti strain KH35c plasmid psymA, complete sequence) position: , mismatch: 9, identity: 0.719

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
atccgcaacacctacaccgccatcaccaatgt	Protospacer
..* *** *************.*****... *

70. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP021801 (Sinorhizobium meliloti strain USDA1021 plasmid psymA, complete sequence) position: , mismatch: 9, identity: 0.719

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
atccgcaacacctacaccgccatcaccaatgt	Protospacer
..* *** *************.*****... *

71. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP021830 (Sinorhizobium meliloti strain HM006 plasmid psymA, complete sequence) position: , mismatch: 9, identity: 0.719

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
atccgcaacacctacaccgccatcaccaatgt	Protospacer
..* *** *************.*****... *

72. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP021824 (Sinorhizobium meliloti strain KH46 plasmid psymA, complete sequence) position: , mismatch: 9, identity: 0.719

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
atccgcaacacctacaccgccatcaccaatgt	Protospacer
..* *** *************.*****... *

73. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP021813 (Sinorhizobium meliloti strain M270 plasmid psymA, complete sequence) position: , mismatch: 9, identity: 0.719

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
atccgcaacacctacaccgccatcaccaatgt	Protospacer
..* *** *************.*****... *

74. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NC_018683 (Sinorhizobium meliloti Rm41 plasmid pSYMA, complete sequence) position: , mismatch: 9, identity: 0.719

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
atccgcaacacctacaccgccatcaccaatgt	Protospacer
..* *** *************.*****... *

75. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP021794 (Sinorhizobium meliloti strain USDA1157 plasmid psymA, complete sequence) position: , mismatch: 9, identity: 0.719

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
atccgcaacacctacaccgccatcaccaatgt	Protospacer
..* *** *************.*****... *

76. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP021809 (Sinorhizobium meliloti strain Rm41 plasmid psymA, complete sequence) position: , mismatch: 9, identity: 0.719

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
atccgcaacacctacaccgccatcaccaatgt	Protospacer
..* *** *************.*****... *

77. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP021805 (Sinorhizobium meliloti strain T073 plasmid psymA, complete sequence) position: , mismatch: 9, identity: 0.719

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
atccgcaacacctacaccgccatcaccaatgt	Protospacer
..* *** *************.*****... *

78. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP010729 (Phaeobacter inhibens strain P88 plasmid pP88_d, complete sequence) position: , mismatch: 9, identity: 0.719

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
cgcggcatcaccgccaccgccgtcacctcggt	Protospacer
  *.********  *************    *

79. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP021217 (Sinorhizobium meliloti RU11/001 plasmid pSymA, complete sequence) position: , mismatch: 9, identity: 0.719

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
atccgcaacacctacaccgccatcaccaatgt	Protospacer
..* *** *************.*****... *

80. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP026526 (Sinorhizobium meliloti strain AK21 plasmid pSymA, complete sequence) position: , mismatch: 9, identity: 0.719

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
atccgcaacacctacaccgccatcaccaatgt	Protospacer
..* *** *************.*****... *

81. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP045361 (Roseivivax sp. THAF40 plasmid pTHAF40_a, complete sequence) position: , mismatch: 9, identity: 0.719

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
gacagcatcacctacacctacgtcatcacgaa	Protospacer
* ****************  *****.*.

82. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP019483 (Sinorhizobium meliloti strain B401 plasmid pSymA, complete sequence) position: , mismatch: 9, identity: 0.719

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
atccgcaacacctacaccgccatcaccaatgt	Protospacer
..* *** *************.*****... *

83. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP045319 (Roseivivax sp. THAF197b plasmid pTHAF197b_a, complete sequence) position: , mismatch: 9, identity: 0.719

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
gacagcatcacctacacctacgtcatcacgaa	Protospacer
* ****************  *****.*.

84. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP019486 (Sinorhizobium meliloti strain B399 plasmid pSymA, complete sequence) position: , mismatch: 9, identity: 0.719

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
atccgcaacacctacaccgccatcaccaatgt	Protospacer
..* *** *************.*****... *

85. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NC_020527 (Sinorhizobium meliloti 2011 plasmid pSymA, complete sequence) position: , mismatch: 9, identity: 0.719

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
atccgcaacacctacaccgccatcaccaatgt	Protospacer
..* *** *************.*****... *

86. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to KT160311 (Vibrio phage H188, complete genome) position: , mismatch: 9, identity: 0.719

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
atgaccatcagccacaccgccgtcaccgtcta	Protospacer
.. * ***** *.*************** *.

87. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NC_007765 (Rhizobium etli CFN 42 plasmid p42e, complete sequence) position: , mismatch: 10, identity: 0.688

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
atggccatcaccagcaccgccgtcaccgccgg	Protospacer
.. . ******* .************** *

88. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP006989 (Rhizobium sp. IE4771 plasmid pRetIE4771c, complete sequence) position: , mismatch: 10, identity: 0.688

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
atggccatcaccagcaccgccgtcaccgccgc	Protospacer
.. . ******* .************** * .

89. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP020909 (Rhizobium etli strain NXC12 plasmid pRetNXC12c, complete sequence) position: , mismatch: 10, identity: 0.688

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
atggccatcaccagcaccgccgtcaccgccgg	Protospacer
.. . ******* .************** *

90. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NC_021908 (Rhizobium etli bv. mimosae str. Mim1 plasmid pRetMIM1d, complete sequence) position: , mismatch: 10, identity: 0.688

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
atggccatcaccagcaccgccgtcaccgccgg	Protospacer
.. . ******* .************** *

91. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to NZ_CP021126 (Rhizobium sp. Kim5 plasmid pRetKim5b, complete sequence) position: , mismatch: 10, identity: 0.688

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
atggccatcaccagcaccgccgtcaccgccgc	Protospacer
.. . ******* .************** * .

92. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to CP007642 (Rhizobium etli bv. phaseoli str. IE4803 plasmid pRetIE4803a, complete sequence) position: , mismatch: 10, identity: 0.688

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
atggccatcaccagcaccgccgtcaccgccgg	Protospacer
.. . ******* .************** *

93. spacer 10.2|3841991|32|NC_015656|PILER-CR matches to MG820641 (Propionibacterium phage pa615, complete genome) position: , mismatch: 10, identity: 0.688

gccagcatcacctacaccgccgtcaccggcct	CRISPR spacer
cacaacatcacctacaccgccctcaacacagc	Protospacer
  **.**************** *** *.   .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

103390 : 171899

Bacillus_phage(18.18%)

transposase,integrase

attL 141352:141394|attR 163391:163433

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013871651.1\|103390_104827_+\|transposase	IS66 family transposase	NA	NA	NA	NA
WP_131771970.1\|105463_105829_-	hypothetical protein	NA	NA	NA	NA
WP_013871652.1\|105839_106817_-	bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase	NA	NA	NA	NA
WP_083828063.1\|106813_108487_-	peptide deformylase	A0A067XQZ3	Caulobacter_phage	4.9e-10	38.5
WP_131771971.1\|108813_109230_+	hypothetical protein	NA	NA	NA	NA
WP_043604302.1\|109286_109706_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_013871656.1\|109849_110938_-\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_013871657.1\|111078_111489_+	hypothetical protein	NA	NA	NA	NA
WP_013871658.1\|111485_111776_+	hypothetical protein	NA	NA	NA	NA
WP_083828065.1\|113397_113991_-	YfcE family phosphodiesterase	NA	NA	NA	NA
WP_013871659.1\|114136_115828_+	MFS transporter	NA	NA	NA	NA
WP_013871660.1\|115951_118072_+	serine/threonine protein kinase	S4VV57	Pandoravirus	1.1e-14	31.7
WP_131773782.1\|118227_118992_-	hypothetical protein	NA	NA	NA	NA
WP_013871663.1\|122216_122519_+	WXG100 family type VII secretion target	NA	NA	NA	NA
WP_013871664.1\|122867_123191_+	hypothetical protein	NA	NA	NA	NA
WP_013871665.1\|123217_123838_+	hypothetical protein	NA	NA	NA	NA
WP_013871666.1\|123916_125101_-	APC family permease	NA	NA	NA	NA
WP_131771975.1\|125814_130599_-	cell division protein FtsK	A0A0K2D129	Bacillus_phage	2.2e-18	33.8
WP_013871668.1\|131129_131861_-	DUF308 domain-containing protein	NA	NA	NA	NA
WP_013871669.1\|132632_134930_-	[protein-PII] uridylyltransferase	NA	NA	NA	NA
WP_043602660.1\|135149_135488_-	P-II family nitrogen regulator	NA	NA	NA	NA
WP_013871671.1\|135490_136786_-	ammonium transporter	H8ZJB2	Ostreococcus_tauri_virus	6.3e-45	32.5
WP_131773784.1\|137181_138369_+	C40 family peptidase	A0A0A8WF62	Clostridium_phage	1.4e-19	43.4
WP_013871673.1\|138419_139181_-	metal-dependent transcriptional regulator	NA	NA	NA	NA
WP_043602667.1\|140767_140977_+	DUF3039 domain-containing protein	NA	NA	NA	NA
141352:141394	attL	NA	NA	NA	NA
WP_013871675.1\|141586_142126_-	cysteine hydrolase	NA	NA	NA	NA
WP_013871676.1\|142122_143328_-	hypothetical protein	NA	NA	NA	NA
WP_013871677.1\|143440_143833_-	GntR family transcriptional regulator	NA	NA	NA	NA
WP_013871679.1\|144108_144318_+	hypothetical protein	NA	NA	NA	NA
WP_013871682.1\|145289_146567_+	group II intron reverse transcriptase/maturase	NA	NA	NA	NA
WP_013871683.1\|147119_148913_+	reverse transcriptase/maturase family protein	D4HTV9	Vibrio_phage	6.7e-13	25.4
WP_131772939.1\|150176_150374_+	hypothetical protein	NA	NA	NA	NA
WP_013871685.1\|150370_150844_+	hypothetical protein	NA	NA	NA	NA
WP_013871686.1\|150843_151596_+	DUF2637 domain-containing protein	NA	NA	NA	NA
WP_013871687.1\|151592_151832_+	hypothetical protein	NA	NA	NA	NA
WP_131796142.1\|151867_153742_+	cell division protein FtsK	A0A2P1JUP2	Bacillus_phage	3.7e-06	37.1
WP_013871689.1\|153730_154819_-\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_043602675.1\|154913_155141_+	hypothetical protein	NA	NA	NA	NA
WP_013871690.1\|155321_155528_+	hypothetical protein	NA	NA	NA	NA
WP_013871692.1\|155702_155909_+	hypothetical protein	NA	NA	NA	NA
WP_013871693.1\|156045_156222_+	hypothetical protein	NA	NA	NA	NA
WP_013871694.1\|156272_156494_+	hypothetical protein	NA	NA	NA	NA
WP_013871695.1\|156571_156913_+	hypothetical protein	NA	NA	NA	NA
WP_013871696.1\|156951_157398_+	NUDIX hydrolase	I4AZJ3	Saccharomonospora_phage	6.5e-26	57.4
WP_013871697.1\|157399_157663_+	hypothetical protein	NA	NA	NA	NA
WP_013871698.1\|157643_157799_+	hypothetical protein	NA	NA	NA	NA
WP_013871699.1\|157867_158254_+	hypothetical protein	NA	NA	NA	NA
WP_013871700.1\|158375_158846_+	single-stranded DNA-binding protein	A0A2H4JEL4	uncultured_Caudovirales_phage	6.8e-42	58.2
WP_013871703.1\|159727_161017_+\|transposase	IS256 family transposase	NA	NA	NA	NA
WP_043602683.1\|162388_163291_+\|integrase	site-specific integrase	G1D5R6	Mycobacterium_phage	1.3e-33	33.6
WP_013871704.1\|164056_165163_+	NDMA-dependent alcohol dehydrogenase	E3SJ82	Synechococcus_phage	2.3e-32	28.8
163391:163433	attR	NA	NA	NA	NA
WP_043602684.1\|165509_166772_+	cytochrome P450	NA	NA	NA	NA
WP_013871706.1\|167072_168221_+	acyl-CoA dehydrogenase family protein	NA	NA	NA	NA
WP_013871707.1\|168648_169914_+	LuxR family transcriptional regulator	NA	NA	NA	NA
WP_013871708.1\|170305_170446_+	hypothetical protein	NA	NA	NA	NA
WP_013872077.1\|170636_171899_-\|transposase	IS4 family transposase	NA	NA	NA	NA

DBSCAN-SWA_2

1921481 : 1956611

Orpheovirus(14.29%)

transposase,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013873050.1\|1921481_1922867_+\|tRNA	glycine--tRNA ligase	A0A2I2L3K8	Orpheovirus	3.7e-43	30.2
WP_131772367.1\|1922939_1923656_-	hypothetical protein	NA	NA	NA	NA
WP_050803403.1\|1925459_1926650_-	toxic anion resistance protein	NA	NA	NA	NA
WP_013873054.1\|1926681_1927782_-	hypothetical protein	NA	NA	NA	NA
WP_013873055.1\|1928292_1930992_+	pyruvate, phosphate dikinase	A0A2D2W2B1	Stenotrophomonas_phage	1.3e-81	40.4
WP_131772368.1\|1931195_1931768_+	YdcF family protein	NA	NA	NA	NA
WP_013873057.1\|1931996_1933874_+	transketolase	NA	NA	NA	NA
WP_013873058.1\|1934045_1934585_-	PH domain-containing protein	NA	NA	NA	NA
WP_013873059.1\|1934626_1934782_-	hypothetical protein	NA	NA	NA	NA
WP_043603239.1\|1934877_1936128_+	deoxyguanosinetriphosphate triphosphohydrolase	NA	NA	NA	NA
WP_013873061.1\|1936606_1938544_+	DNA primase	A0A1S5RFR1	Helicobacter_phage	2.2e-38	31.4
WP_013873062.1\|1938584_1939763_+	RNA polymerase sigma factor	F4YCU2	Synechococcus_phage	1.5e-42	37.6
WP_131772369.1\|1939990_1940905_+	class E sortase	NA	NA	NA	NA
WP_131772370.1\|1941232_1942573_+	hypothetical protein	NA	NA	NA	NA
WP_131773915.1\|1943018_1944224_+\|transposase	transposase	NA	NA	NA	NA
WP_013873067.1\|1944614_1946714_-\|transposase	ISAzo13 family transposase	NA	NA	NA	NA
WP_085948540.1\|1949036_1950214_-\|transposase	IS3 family transposase	U5P429	Shigella_phage	3.1e-43	40.2
WP_013873070.1\|1950356_1951331_+	daunorubicin resistance protein DrrA family ABC transporter ATP-binding protein	A0A2R8FG22	Brazilian_cedratvirus	9.6e-14	32.7
WP_013873071.1\|1951327_1952263_+	ABC transporter permease	NA	NA	NA	NA
WP_013871791.1\|1952391_1952733_+	hypothetical protein	NA	NA	NA	NA
WP_013873072.1\|1952729_1953812_+\|transposase	IS66 family transposase	NA	NA	NA	NA
WP_013873074.1\|1954808_1955987_+\|transposase	ISAzo13 family transposase	NA	NA	NA	NA
WP_013873075.1\|1956233_1956611_+\|transposase	transposase	A0A1B3AZF8	Gordonia_phage	2.8e-22	56.6

DBSCAN-SWA_3

2432202 : 2508096

Staphylococcus_phage(25.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013871712.1\|2432202_2433291_+\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_013873411.1\|2433369_2434173_+	enoyl-CoA hydratase/isomerase family protein	NA	NA	NA	NA
WP_013873412.1\|2434332_2434971_+	TetR family transcriptional regulator	NA	NA	NA	NA
WP_083828226.1\|2435082_2435475_-	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_013873413.1\|2435572_2437207_+	acyl-CoA synthetase	NA	NA	NA	NA
WP_013873414.1\|2437554_2438517_-	hypothetical protein	NA	NA	NA	NA
WP_013873415.1\|2438566_2439349_-	hypothetical protein	NA	NA	NA	NA
WP_013873416.1\|2440228_2441089_+	ABC transporter permease	NA	NA	NA	NA
WP_131772442.1\|2441114_2441963_+	ABC transporter permease	NA	NA	NA	NA
WP_131773950.1\|2442931_2444119_+	MCE family protein	NA	NA	NA	NA
WP_013873419.1\|2444115_2445375_+	MCE family protein	NA	NA	NA	NA
WP_013873420.1\|2445510_2446800_+	MCE family protein	NA	NA	NA	NA
WP_013873421.1\|2446796_2448272_+	MCE family protein	NA	NA	NA	NA
WP_013873422.1\|2448268_2449564_+	MCE family protein	NA	NA	NA	NA
WP_013873423.1\|2449560_2450850_+	MCE family protein	NA	NA	NA	NA
WP_013873424.1\|2451009_2453373_+	RND transporter	NA	NA	NA	NA
WP_013873425.1\|2453369_2454545_+	peptidyl-prolyl cis-trans isomerase	NA	NA	NA	NA
WP_043603387.1\|2454553_2454760_+	hypothetical protein	NA	NA	NA	NA
WP_013873427.1\|2454867_2455905_-	TIGR03617 family F420-dependent LLM class oxidoreductase	NA	NA	NA	NA
WP_013873428.1\|2456390_2457581_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_131772443.1\|2458103_2459015_+	GAF domain-containing protein	NA	NA	NA	NA
WP_013873430.1\|2459011_2460235_+	GAF domain-containing protein	NA	NA	NA	NA
WP_013873431.1\|2460507_2461719_-	acyl-CoA/acyl-ACP dehydrogenase	NA	NA	NA	NA
WP_013873432.1\|2462346_2462736_+	hypothetical protein	NA	NA	NA	NA
WP_050803755.1\|2462840_2463761_+	nitronate monooxygenase	NA	NA	NA	NA
WP_013873434.1\|2463768_2465343_+	AMP-binding protein	A0A2H4PQM9	Staphylococcus_phage	3.7e-31	25.0
WP_085948550.1\|2465435_2465972_+	flavin reductase family protein	NA	NA	NA	NA
WP_013873436.1\|2466019_2467531_+	aldehyde dehydrogenase	NA	NA	NA	NA
WP_043605993.1\|2467675_2468887_+	acetyl-CoA C-acetyltransferase	NA	NA	NA	NA
WP_013873438.1\|2468916_2471085_+	enoyl-CoA hydratase/isomerase family protein	NA	NA	NA	NA
WP_043603389.1\|2471428_2471839_+\|transposase	transposase	NA	NA	NA	NA
WP_013873441.1\|2472069_2473224_+	acyl-CoA/acyl-ACP dehydrogenase	NA	NA	NA	NA
WP_013873442.1\|2473234_2474869_+	acetyl-CoA carboxylase	NA	NA	NA	NA
WP_013873443.1\|2474874_2476863_+	ATP-grasp domain-containing protein	NA	NA	NA	NA
WP_013873444.1\|2476927_2477725_+	TIGR03084 family protein	NA	NA	NA	NA
WP_050803757.1\|2477780_2479580_+	DUF1446 domain-containing protein	NA	NA	NA	NA
WP_131773949.1\|2483389_2484052_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_013873448.1\|2484436_2484643_-	hypothetical protein	NA	NA	NA	NA
WP_013872683.1\|2484748_2486185_-\|transposase	IS66 family transposase	NA	NA	NA	NA
WP_131772445.1\|2487911_2488121_+	hypothetical protein	NA	NA	NA	NA
WP_013873450.1\|2488618_2489200_-	NodA family N-acyltransferase	NA	NA	NA	NA
WP_083828229.1\|2489358_2490072_-	chitooligosaccharide deacetylase NodB	NA	NA	NA	NA
WP_013873453.1\|2490462_2491737_-	DegT/DnrJ/EryC1/StrS family aminotransferase	A0A2K9L0G1	Tupanvirus	6.6e-55	35.2
WP_013873454.1\|2491807_2493226_-	FAD-binding protein	NA	NA	NA	NA
WP_013873455.1\|2493924_2494791_+\|transposase	IS5 family transposase	A0A0N9SHJ4	Paenibacillus_phage	2.1e-12	42.4
WP_157491004.1\|2494718_2494916_-\|transposase	IS3 family transposase	U5P429	Shigella_phage	8.1e-05	37.9
WP_013871682.1\|2495511_2496789_+	group II intron reverse transcriptase/maturase	NA	NA	NA	NA
WP_193353109.1\|2499512_2499872_+	hypothetical protein	NA	NA	NA	NA
WP_050803466.1\|2500272_2500563_+	hypothetical protein	NA	NA	NA	NA
WP_083828231.1\|2505033_2505699_+	MFS transporter	NA	NA	NA	NA
WP_013871712.1\|2507007_2508096_-\|transposase	IS630 family transposase	NA	NA	NA	NA

DBSCAN-SWA_4

2808726 : 2880097

Bacillus_phage(27.27%)

transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_085948540.1\|2808726_2809904_-\|transposase	IS3 family transposase	U5P429	Shigella_phage	3.1e-43	40.2
WP_043603512.1\|2810020_2810239_+	hypothetical protein	NA	NA	NA	NA
WP_013873677.1\|2810334_2810556_+	type II toxin-antitoxin system RelE/ParE family toxin	NA	NA	NA	NA
WP_050803771.1\|2810576_2810759_-	hypothetical protein	NA	NA	NA	NA
WP_083828480.1\|2811080_2812142_-	1-acyl-sn-glycerol-3-phosphate acyltransferase	NA	NA	NA	NA
WP_013873680.1\|2812189_2813749_-	DUF2088 domain-containing protein	NA	NA	NA	NA
WP_013873681.1\|2813908_2815210_-	zinc-binding dehydrogenase	NA	NA	NA	NA
WP_013873682.1\|2815206_2817582_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_050803489.1\|2817854_2818769_-	5'-3' exonuclease	F8WQ40	Bacillus_phage	7.1e-11	30.6
WP_043606139.1\|2818916_2819360_+	Lrp/AsnC family transcriptional regulator	NA	NA	NA	NA
WP_083828242.1\|2819526_2821317_+	amidohydrolase family protein	NA	NA	NA	NA
WP_043603525.1\|2822354_2822729_+	multidrug efflux SMR transporter	NA	NA	NA	NA
WP_013873688.1\|2824266_2826951_+	apolipoprotein N-acyltransferase	A0A0N7A8R9	Sulfolobus_monocaudavirus	3.5e-26	41.4
WP_013873689.1\|2827028_2827379_-	RNA polymerase-binding protein RbpA	NA	NA	NA	NA
WP_043606146.1\|2828039_2828477_+	peptide-methionine (R)-S-oxide reductase MsrB	NA	NA	NA	NA
WP_013873691.1\|2829320_2830886_+	AMP-binding protein	NA	NA	NA	NA
WP_013873692.1\|2831134_2831758_+	cyclodeaminase/cyclohydrolase family protein	NA	NA	NA	NA
WP_013873693.1\|2831754_2832582_+	bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-methenyltetrahydrofolate cyclohydrolase	A0A249XZQ2	Enterococcus_phage	2.1e-25	34.4
WP_013873694.1\|2832694_2834062_-	GGDEF domain-containing protein	A0A127AWB9	Bacillus_phage	3.5e-14	38.1
WP_013873695.1\|2834637_2835972_-	adenosylmethionine--8-amino-7-oxononanoate transaminase	NA	NA	NA	NA
WP_013873696.1\|2836389_2836686_+	GlsB/YeaQ/YmgE family stress response membrane protein	NA	NA	NA	NA
WP_085948595.1\|2836900_2837686_+	phytanoyl-CoA dioxygenase family protein	NA	NA	NA	NA
WP_013873698.1\|2837835_2838678_+\|protease	rhomboid family intramembrane serine protease	NA	NA	NA	NA
WP_013873699.1\|2838912_2839506_-	hypothetical protein	NA	NA	NA	NA
WP_013873700.1\|2839850_2840027_+	hypothetical protein	NA	NA	NA	NA
WP_013873701.1\|2841264_2841759_-	hypothetical protein	NA	NA	NA	NA
WP_043606153.1\|2842106_2845499_+	pyruvate carboxylase	NA	NA	NA	NA
WP_131772495.1\|2845729_2846530_+	AfsR/SARP family transcriptional regulator	NA	NA	NA	NA
WP_157491007.1\|2846724_2846880_+	lasso RiPP family leader peptide-containing protein	NA	NA	NA	NA
WP_013873705.1\|2847255_2849163_+	lasso peptide isopeptide bond-forming cyclase	NA	NA	NA	NA
WP_013873706.1\|2849159_2849429_+	lasso peptide biosynthesis PqqD family chaperone	NA	NA	NA	NA
WP_013873707.1\|2849464_2849926_+	lasso peptide biosynthesis B2 protein	NA	NA	NA	NA
WP_013873708.1\|2849922_2851923_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	2.3e-46	26.7
WP_013873709.1\|2852089_2852686_-	LppP/LprE family lipoprotein	NA	NA	NA	NA
WP_013871712.1\|2853208_2854297_-\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_013873710.1\|2854337_2855723_-	M20/M25/M40 family metallo-hydrolase	NA	NA	NA	NA
WP_013873711.1\|2855926_2856781_+	hypothetical protein	NA	NA	NA	NA
WP_050803491.1\|2857040_2857676_-	hypothetical protein	E5ERA2	Bathycoccus_sp._RCC1105_virus	3.4e-12	28.5
WP_157491009.1\|2857588_2858122_-	hypothetical protein	E5ERA2	Bathycoccus_sp._RCC1105_virus	2.8e-07	36.5
WP_013873712.1\|2858491_2858947_-	redox-sensitive transcriptional activator SoxR	NA	NA	NA	NA
WP_043606159.1\|2859076_2859370_+	NAD(P)H-dependent oxidoreductase	NA	NA	NA	NA
WP_083828246.1\|2860592_2860904_+	NAD(P)H-dependent oxidoreductase	NA	NA	NA	NA
WP_131772499.1\|2861401_2861863_+	hypothetical protein	NA	NA	NA	NA
WP_013871712.1\|2861903_2862992_+\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_131772501.1\|2864790_2866368_+	MFS transporter	A0A0M3UL24	Mycobacterium_phage	2.8e-39	30.8
WP_083828248.1\|2866787_2867309_+	hypothetical protein	NA	NA	NA	NA
WP_013873715.1\|2867372_2868170_-	ABC transporter permease	NA	NA	NA	NA
WP_131772500.1\|2868166_2869303_-	ATP-binding cassette domain-containing protein	A0A2H4PQG7	Staphylococcus_phage	4.8e-33	38.6
WP_013873717.1\|2869478_2870129_-	response regulator transcription factor	NA	NA	NA	NA
WP_013873718.1\|2870125_2870884_-	putative signal transduction histidine kinase	NA	NA	NA	NA
WP_013873719.1\|2871047_2871530_+	hypothetical protein	NA	NA	NA	NA
WP_013873720.1\|2872037_2872328_+	metal-sensitive transcriptional regulator	NA	NA	NA	NA
WP_013873721.1\|2872510_2872732_+	heavy-metal-associated domain-containing protein	NA	NA	NA	NA
WP_013873722.1\|2872888_2875396_+	copper-translocating P-type ATPase	A0A218MNH6	uncultured_virus	7.0e-93	34.0
WP_013873724.1\|2876318_2876693_-	hypothetical protein	NA	NA	NA	NA
WP_013873725.1\|2876696_2876918_-	hypothetical protein	NA	NA	NA	NA
WP_013871712.1\|2877505_2878594_-\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_013871651.1\|2878660_2880097_-\|transposase	IS66 family transposase	NA	NA	NA	NA

DBSCAN-SWA_5

4148747 : 4156689

Mycobacterium_phage(50.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_085948540.1\|4148747_4149925_-\|transposase	IS3 family transposase	U5P429	Shigella_phage	3.1e-43	40.2
WP_013874693.1\|4149945_4151031_-	ADP-ribosylglycohydrolase family protein	A0A1I9SA26	Rhodococcus_phage	2.9e-11	29.7
WP_013874694.1\|4151206_4151662_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_013874695.1\|4151672_4152146_+	VOC family protein	NA	NA	NA	NA
WP_131774070.1\|4152093_4153431_-	adenylosuccinate synthetase	C9DBY1	Mycobacterium_phage	3.2e-76	43.5
WP_013874697.1\|4153514_4154507_-	hypothetical protein	G1JVU5	Mycobacterium_phage	1.5e-62	41.1
WP_013874698.1\|4154572_4155784_-	molecular chaperone DnaJ	C9DB41	Mycobacterium_phage	5.5e-51	35.5
WP_013874699.1\|4155780_4156689_-	NUDIX hydrolase	A0A0E3JJF3	Streptomyces_phage	2.6e-13	36.5

DBSCAN-SWA_6

4948462 : 5025622

Mycobacterium_phage(22.22%)

holin,transposase,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013871651.1\|4948462_4949899_-\|transposase	IS66 family transposase	NA	NA	NA	NA
WP_013875361.1\|4950329_4951289_-	5'/3'-nucleotidase SurE	NA	NA	NA	NA
WP_131772904.1\|4951474_4952632_-	YncE family protein	NA	NA	NA	NA
WP_013875364.1\|4952988_4954503_-	MFS transporter	A0A0M3UL24	Mycobacterium_phage	1.1e-51	36.2
WP_013875365.1\|4954573_4955008_+	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_013875366.1\|4955249_4956725_+	MFS transporter	A0A0M3UL24	Mycobacterium_phage	6.9e-24	28.3
WP_083828380.1\|4956763_4957447_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_157491048.1\|4957550_4959269_-	DHA2 family efflux MFS transporter permease subunit	NA	NA	NA	NA
WP_131772905.1\|4959403_4960273_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_013875370.1\|4960301_4960943_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_013875371.1\|4961058_4961841_+	NmrA family NAD(P)-binding protein	NA	NA	NA	NA
WP_013871712.1\|4961950_4963039_-\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_013875372.1\|4963079_4963967_-	acid phosphatase	NA	NA	NA	NA
WP_193353124.1\|4964611_4965340_+	amino acid ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	5.3e-33	38.2
WP_083828382.1\|4965391_4966321_+	glutamate ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_013875375.1\|4966427_4967078_+	amino acid ABC transporter permease	NA	NA	NA	NA
WP_013875376.1\|4967074_4967932_+	amino acid ABC transporter permease	NA	NA	NA	NA
WP_013875377.1\|4967974_4968901_-	TauD/TfdA family dioxygenase	NA	NA	NA	NA
WP_131772907.1\|4969343_4970639_-	ROK family transcriptional regulator	NA	NA	NA	NA
WP_131772908.1\|4971032_4971212_+	hypothetical protein	NA	NA	NA	NA
WP_013875382.1\|4972187_4972379_-	hypothetical protein	NA	NA	NA	NA
WP_013875383.1\|4972804_4973704_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	4.1e-35	37.9
WP_013875384.1\|4973700_4974933_+	ABC transporter permease	NA	NA	NA	NA
WP_013875386.1\|4975092_4977300_+	biotin/lipoyl-binding protein	NA	NA	NA	NA
WP_083828555.1\|4977382_4979539_-\|holin	choline/carnitine O-acyltransferase	NA	NA	NA	NA
WP_013875388.1\|4980353_4981223_-	hypothetical protein	NA	NA	NA	NA
WP_013875389.1\|4981929_4982850_+	NADP-dependent oxidoreductase	NA	NA	NA	NA
WP_013875390.1\|4983064_4983631_+	hypothetical protein	NA	NA	NA	NA
WP_131772912.1\|4983934_4984783_+	hypothetical protein	NA	NA	NA	NA
WP_013875392.1\|4984965_4985280_-	SHOCT domain-containing protein	NA	NA	NA	NA
WP_013875393.1\|4985579_4986371_-	lactate utilization protein C	NA	NA	NA	NA
WP_083828384.1\|4987924_4988770_-	(Fe-S)-binding protein	NA	NA	NA	NA
WP_013875395.1\|4989684_4991154_+	hypothetical protein	NA	NA	NA	NA
WP_131774116.1\|4991458_4992460_+	protein phosphatase 2C domain-containing protein	NA	NA	NA	NA
WP_013875397.1\|4992456_4993737_+	VWA domain-containing protein	NA	NA	NA	NA
WP_013875398.1\|4993741_4994983_+	FHA domain-containing protein	NA	NA	NA	NA
WP_013875400.1\|4995273_4996860_-\|tRNA	cysteine--tRNA ligase	A0A1V0SAQ2	Catovirus	1.8e-38	29.7
WP_013875401.1\|4997181_4997577_-	PPOX class F420-dependent oxidoreductase	NA	NA	NA	NA
WP_043607315.1\|4997708_4998185_-	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	NA	NA	NA	NA
WP_043604166.1\|4998536_4999220_-	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	NA	NA	NA	NA
WP_006545253.1\|4999281_4999764_-	CarD family transcriptional regulator	NA	NA	NA	NA
WP_013875405.1\|5000218_5001112_+	hypothetical protein	NA	NA	NA	NA
WP_013875406.1\|5001511_5002069_+	hypothetical protein	NA	NA	NA	NA
WP_013875407.1\|5002292_5003744_+	DNA repair protein RadA	NA	NA	NA	NA
WP_043604169.1\|5003852_5004932_+	DNA integrity scanning protein DisA	NA	NA	NA	NA
WP_131772916.1\|5005134_5006217_+	A/G-specific adenine glycosylase	NA	NA	NA	NA
WP_013875410.1\|5006460_5006745_+	hypothetical protein	NA	NA	NA	NA
WP_013875411.1\|5006946_5008350_+\|tRNA	proline--tRNA ligase	A0A2K9L0T2	Tupanvirus	1.3e-85	39.8
WP_013875412.1\|5008564_5009068_+	DUF3618 domain-containing protein	NA	NA	NA	NA
WP_050803612.1\|5009300_5010527_-	GGDEF domain-containing protein	A0A127AWB9	Bacillus_phage	6.8e-17	33.9
WP_050803613.1\|5010492_5010852_-	hypothetical protein	NA	NA	NA	NA
WP_013875414.1\|5012395_5014018_+	serine/threonine protein kinase	T2AWK4	Cannes_8_virus	1.8e-12	27.6
WP_013875415.1\|5014302_5014650_+	hypothetical protein	NA	NA	NA	NA
WP_131772921.1\|5015053_5015551_+	two pore domain potassium channel family protein	NA	NA	NA	NA
WP_013873771.1\|5016158_5017247_-\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_043604171.1\|5017258_5017954_+	hypothetical protein	A0A1J0MBX1	Streptomyces_phage	4.7e-15	36.7
WP_013875417.1\|5018246_5019386_+\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_013871651.1\|5024185_5025622_+\|transposase	IS66 family transposase	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_015656

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection