CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_014759	Marivirga tractuosa DSM 4126, complete sequence	3 crisprs	Cas9_archaeal,DEDDh,DinG,cas3,csa3,cas6	0	0	0	0
NC_014750	Marivirga tractuosa DSM 4126 plasmid pFTRAC01, complete sequence	0 crisprs	NA	0	0	0	0

1. NC_014759

CRISPR-Cas detection and classification

Crispr_ID: NC_014759_2

• CRISPR_ID: NC_014759_2
• CRISPR_location: 2482963-2483057
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_014759_2

Consensus_repeat	Method
TCCATCATTTTCTCCATCATTTG	CRISPRCasFinder

spacers of NC_014759_2

>2.1|2482986|49|NC_014759|CRISPRCasFinder
ACTATCATTCATAATAGTAGTGAATACCTCTTGCTGCTTATTCTCTTTT

CRISPR arrays and Neighbor proteins around NC_014759_2

CRISPR arrays

The CRISPR arrays of NC_014759_2

>merge|NC_014759|2|2482963-2483057|CRISPRCasFinder
TGCATGAATTTGTTCATCATCTCACTATCATTCATAATAGTAGTGAATACCTCTTGCTGCTTATTCTCTTTTTTCATCATTTTTTCCACGTTTTG

>NC_014759|2|2|2482963-2483057|CRISPRCasFinder
TGCATGAATTTGTTCATCATCTC	ACTATCATTCATAATAGTAGTGAATACCTCTTGCTGCTTATTCTCTTTT
TTCATCATTTTTTCCACGTTTTG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_014759.1|WP_013454219.1|2474229_2474889_-|hypothetical-protein	unknown	unknown	unknown
NC_014759.1|WP_041650609.1|2474984_2475287_-|hypothetical-protein	unknown	unknown	unknown
NC_014759.1|WP_013454226.1|2481035_2481722_-|rhodanese-like-domain-containing-protein	unknown	unknown	gnl|CDD|238089
NC_014759.1|WP_148230154.1|2488362_2488851_-|DUF3347-domain-containing-protein	unknown	unknown	gnl|CDD|378730
NC_014759.1|WP_013454222.1|2477005_2477524_-|hypothetical-protein	unknown	unknown	unknown
NC_014759.1|WP_041649737.1|2483431_2483674_-|DUF302-domain-containing-protein	unknown	unknown	gnl|CDD|269820
NC_014759.1|WP_013454232.1|2486838_2487408_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|225117
NC_014759.1|WP_049784106.1|2475333_2476494_-|permease	unknown	unknown	gnl|CDD|281730
NC_014759.1|WP_013454236.1|2489037_2490828_-|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl|CDD|379862
NC_014759.1|WP_041649740.1|2483706_2483895_-|hypothetical-protein	unknown	unknown	unknown
NC_014759.1|WP_148230070.1|2476748_2476970_-|hypothetical-protein	unknown	unknown	unknown
NC_014759.1|WP_013454231.1|2484383_2486684_-|multicopper-oxidase-domain-containing-protein	unknown	unknown	gnl|CDD|273649
NC_014759.1|WP_013454233.1|2487397_2487799_-|hypothetical-protein	unknown	unknown	unknown
NC_014759.1|WP_013454230.1|2483904_2484291_-|DUF302-domain-containing-protein	unknown	unknown	gnl|CDD|269820
NC_014759.1|WP_013454223.1|2477527_2479222_-|multicopper-oxidase-domain-containing-protein	unknown	unknown	gnl|CDD|259946
NC_014759.1|WP_081457048.1|2482113_2482362_-|YHS-domain-containing-protein	unknown	unknown	gnl|CDD|225886
NC_014759.1|WP_013454225.1|2480693_2480906_-|SHOCT-domain-containing-protein	unknown	unknown	gnl|CDD|225993
NC_014759.1|WP_013454224.1|2479373_2480690_-|APC-family-permease	unknown	unknown	gnl|CDD|223605
NC_014759.1|WP_013454234.1|2487928_2488351_-|hypothetical-protein	unknown	unknown	unknown
NC_014759.1|WP_148230153.1|2483195_2483393_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_014759.1|WP_049784106.1|2475333_2476494_-|permease	gnl|CDD|281730	pfam03773, ArsP_1, Predicted permease. This family of integral membrane proteins are predicted to be permeases of unknown specificity.	1.41704e-46
NC_014759.1|WP_148230154.1|2488362_2488851_-|DUF3347-domain-containing-protein	gnl|CDD|378730	pfam11827, DUF3347, Protein of unknown function (DUF3347). This family of proteins are functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 169 to 570 amino acids in length.	5.28331e-48
NC_014759.1|WP_041649737.1|2483431_2483674_-|DUF302-domain-containing-protein	gnl|CDD|269820	cd14797, DUF302, Uncharacterized domain family DUF302. These domains are mostly found in bacterial single-domain proteins and have been shown to form homodimers; they may also bind zinc. Also characterized as COG3439.	5.86822e-12
NC_014759.1|WP_013454232.1|2486838_2487408_-|helix-turn-helix-domain-containing-protein	gnl|CDD|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	1.08812e-16
NC_014759.1|WP_013454231.1|2484383_2486684_-|multicopper-oxidase-domain-containing-protein	gnl|CDD|273649	TIGR01480, unnamed_protein_product, copper-resistance protein, CopA family. This model represents the CopA copper resistance protein family. CopA is related to laccase (benzenediol:oxygen oxidoreductase) and L-ascorbate oxidase, both copper-containing enzymes. Most members have a typical TAT (twin-arginine translocation) signal sequence with an Arg-Arg pair. Twin-arginine translocation is observed for a large number of periplasmic proteins that cross the inner membrane with metal-containing cofactors already bound. The combination of copper-binding sites and TAT translocation motif suggests a mechansism of resistance by packaging and export. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds].	1.96429e-119
NC_014759.1|WP_013454236.1|2489037_2490828_-|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl|CDD|379862	pfam16576, HlyD_D23, Barrel-sandwich domain of CusB or HlyD membrane-fusion. HlyD_D23 is the combined domains 2 and 3 of the membrane-fusion proteins CusB and HlyD, which forms a barrel-sandwich. CusB and HlyD proteins are membrane fusion proteins of the CusCFBA copper efflux system in E.coli and related bacteria. The whole molecule hinges between D2 and D3. Efflux systems of this resistance-nodulation-division group - RND - have been developed to excrete poisonous metal ions, and in E.coli the only one that deals with silver and copper is the CusA transporter. The transporter CusA works in conjunction with a periplasmic component that is a membrane fusion protein, eg CusB, and an outer-membrane channel component CusC in a CusABC complex driven by import of protons.	1.4926e-91
NC_014759.1|WP_013454223.1|2477527_2479222_-|multicopper-oxidase-domain-containing-protein	gnl|CDD|259946	cd13879, CuRO_2_McoP_like, The second cupredoxin domain of multicopper oxidase McoP and similar proteins. This family includes archaeal and bacterial multicopper oxidases (MCOs), represented by the extremely thermostable McoP from the hyperthermophilic archaeon Pyrobaculum aerophilum. McoP is an efficient metallo-oxidase that catalyzes the oxidation of cuprous and ferrous ions. It is noteworthy that McoP has three-fold higher catalytic efficiency when using nitrous oxide as electron acceptor than when using dioxygen, the typical oxidizing substrate of multicopper oxidases. McoP may function as a novel archaeal nitrous oxide reductase that is probably involved in the denitrification pathway in archaea. Although MCOs have diverse functions, majority of them have three cupredoxin domain repeats that include one mononuclear and one trinuclear copper center. The copper ions are bound in several sites: Type 1, Type 2, and/or Type 3. The ensemble of types 2 and 3 copper is called a trinuclear cluster. MCOs oxidize their substrate by accepting electrons at a mononuclear copper center and transferring them to the active site trinuclear copper center. The cupredoxin domain 2 of 3-domain MCOs has lost the ability to bind copper.	7.92461e-81
NC_014759.1|WP_081457048.1|2482113_2482362_-|YHS-domain-containing-protein	gnl|CDD|225886	COG3350, COG3350, Uncharacterized conserved protein [Function unknown].	3.52808e-11
NC_014759.1|WP_013454225.1|2480693_2480906_-|SHOCT-domain-containing-protein	gnl|CDD|225993	COG3462, COG3462, Predicted membrane protein [Function unknown].	8.38678e-08
NC_014759.1|WP_013454224.1|2479373_2480690_-|APC-family-permease	gnl|CDD|223605	COG0531, PotE, Amino acid transporters [Amino acid transport and metabolism].	1.20472e-27
NC_014759.1|WP_013454226.1|2481035_2481722_-|rhodanese-like-domain-containing-protein	gnl|CDD|238089	cd00158, RHOD, Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and certain stress proteins such as senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions (no active site cysteine) are also seen in dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases, where they are believed to play a regulatory role in multidomain proteins.	8.35784e-11
NC_014759.1|WP_013454230.1|2483904_2484291_-|DUF302-domain-containing-protein	gnl|CDD|269820	cd14797, DUF302, Uncharacterized domain family DUF302. These domains are mostly found in bacterial single-domain proteins and have been shown to form homodimers; they may also bind zinc. Also characterized as COG3439.	4.68721e-43

Protein sequences

>NC_014759.1|WP_081457048.1|2482113_2482362_-|YHS-domain-containing-protein
MDPTCGIVVNEHTAISYSYQGTIYYFDTEECLSVFKKNPNKFIKDSRGNWNVNASHMGWWLPATGGIMVVGMTLAMILGLNH
>NC_014759.1|WP_013454226.1|2481035_2481722_-|rhodanese-like-domain-containing-protein
MEISIAATKTCPHRPILENELKHARLPFKVIYFDEHPELLEKYQLKHSPLLIVDEQVESIGMPGMEKIEELKTRNVDLSQIRIPKRDNNHMIPNRVKAEPGLVEVDTTWGSIQPMQVAHGVLTVEELKVHYHQKMNLPIIDARKPDTNDAISIAGSKNIPFDEVVKRIDEIDKNHPSIFFCNGPQCPQSSTAIKNLLKAGYPADKILYYRGGMHDWITLGLPVEEISV
>NC_014759.1|WP_013454225.1|2480693_2480906_-|SHOCT-domain-containing-protein
MMYGWIIGVILIVVLIVALGRGGIFQKNSGETADSHHDDSAMETLKNRYARGEIDKAEFEEKKAELKKTK
>NC_014759.1|WP_013454224.1|2479373_2480690_-|APC-family-permease
MGKYKKNSLSLTGAISLGTGVMIGAAIFALLGQVAELSGSLFPIAFLVGAIIAGFSAYAYIKMSNAYPSAGGIAMYLKKAYGKGITTAVAALLMAFAMVINQSLVARTFGSYTMQLFDGNQNDFWIPLLGVILLVITFLINLAGNKVIDRVSFFMAIIKVGGIAIFAIGGLWAAGFSFGEAIPSEISGDYSVGSYLGALALAILAYAGFTTITNSGEEIVEPHKNVGRAIWISLIICTIVYLLVAFAVSVNLSVPKIIEAKDYSLAEAARPAFGKYGLWFTVGIAIIATVSSVLANVFAISRMTTMLTEMKLIPHKHFGMPGNLQQHMLTYTIVIAIALTIFFDLSRIASLGAIFYLIMDIIIQWGVFKHLRKEIKANGAILLATIVLDVVVLAAFIWMKAQSDMLLIIVSAVLLTLIIAGEKWFLKMRKFKVESSNN
>NC_014759.1|WP_013454223.1|2477527_2479222_-|multicopper-oxidase-domain-containing-protein
MKEPFRINRRKFLAKAGAGAAVTMIWPFFSSCDSQSSTTAKPKLSKDFQPDIDLELKAVQRDLSILPGSKTKVWVYEGKLIKGNKEALLPLQGSYLGPIIKVRKGQKVRIRFQNDLPEESIVHWHGMHVPERYDGHPQDVIDSGETYIYEYEVMNRAGTYWFHPHPHGRTGPQVYNGLAGLLLVTDEEEQQLNLPQGEFDLPVVIQDRTFDDNNQLVYLENGQMGRMTGFLGNRILINGRPEQRLNLKAGCKYRLRLLNGSNSRIYKLAWEDGSPVTVFGMDGSLLNAPKELSYLMLGPAKRADVWLDLTNKPEGTELTMKNTSFPLELMSGGMMGNGGMMEGAKSVLPQGSEYPVFTVLANASGSNDYTLPRQLAQPDYIDPSTAGNLNAPRQFTFAMGHMEWTINGRTWETTEVADEEIVKLGSIEVWELINGGGMMDNDDDGGGMMDGHGTMDNGGMMRGDDGMMSGGGMMGNMMQMPHPIHIHQVQFNILERNVTDVDPQLWDAVKDGFVDEGWHDTVLLMPGMSAKVIMQFKDFKGLFVYHCHNLEHEDMGMMRNFKIV
>NC_014759.1|WP_013454222.1|2477005_2477524_-|hypothetical-protein
MDNLSFGIFVVPIITLTLIIMLYIHFFRKAADKRNYQYFVARTSVVAFVLNFGWEVAHGFLYENFQYDLEHVSFCALASIADVLMVLVLLFLFGLIYNNVYWIRRLKFTRTLLLVLVGFLGAILGEFWHTWRGDWSYADTMPMLPLIEVGLSPVLQFSILPLIIFLISRRKI
>NC_014759.1|WP_148230070.1|2476748_2476970_-|hypothetical-protein
MKHEKQAKLNKVKGQIGYAMMWFFLAGLIETLMYLGKIEMFIYHIVALALSAVGCFKVFKGFENYKHYKNEGK
>NC_014759.1|WP_049784106.1|2475333_2476494_-|permease
MGFFWKSGWAFVLGYIISSMIQAFVPKKKLTQQMGKGNVKSISLSTLFGSISSSCSFAALAAARSLFQKGAHFISTVAFMFASTNLVIELGILIFIFLGWQFIVAEVIGGLILITISGLIIKLTSPKKWIKAAREKVEDESAEEEDFDWKERIKSKEGWFLVGKKFVMEWKMAWEDILIGFTIAGFVSVLVPQSFWEAIFLNGMQGELPDFVIRLENALVAPFVAAATFIGSMGNIPLATVLNENGILFAGLMGFIYSDLMVPPLVNMNRKYYGTRIALYIAGVMYVSIVITALILNYSFDLLGVLPEGSRKVKEVTQFKIDYTFYFNIVFAAFTALMLYFNFRTKKMETDGGHDHEHGGGGISFKRVVVYTFVLIVGIGLVIFLL
>NC_014759.1|WP_041650609.1|2474984_2475287_-|hypothetical-protein
MKTYETLSEALKDLKERGYSNDFNLKPHCIECPADKLELHPEQFEVKEVYRFEGMSNPDDNSILYAIKSTDGLKGVLVDAYGVYSEALSEAMINKLVVNR
>NC_014759.1|WP_013454219.1|2474229_2474889_-|hypothetical-protein
MKKLGLLLYFMLSCIVLSAHEGEKHEKSTKEDSTHLEQPQVDYSHIQAQQEHEHDEHETKKVTADLDDFPNLHPLMVHFPIVLLLIGAVLAIVNVILLKKEVDWVITGMVLVGALGAYLSGRTFHPHTHDLTEHAKQVLAQHDLWADWTIYLSIAGFVAQAVSQFIFRQKRWAVAVVALLLIASGYVVSRTGHYGAQLVHIEAVGPQGKFLESEEGHAH
>NC_014759.1|WP_148230153.1|2483195_2483393_-|hypothetical-protein
MLVGVFATACNNPGGNGNQDHGDVMEDNQTEMMEGDNDHMHEDGQSDEHIMSDTTSMDMNDEMER
>NC_014759.1|WP_041649737.1|2483431_2483674_-|DUF302-domain-containing-protein
MCNAALAIDALSVENKVGIMLPCNIIIQETGEEGVLEVAVTDPLAALEIADNGKLKSLGKRAKDQLQKALNEVEHQNNKL
>NC_014759.1|WP_041649740.1|2483706_2483895_-|hypothetical-protein
MSDKNKIAKENYKESMETSYCISKRFGSMTFQEAIDYSKKAFENNGFEVVMHFDLQNHIKKN
>NC_014759.1|WP_013454230.1|2483904_2484291_-|DUF302-domain-containing-protein
MKYYHEKTLKGVSFEEAIQKVTDALKEEGFGILTEIDVKETLKKKLDEDFRPYKILGACNPPFAHKALLAEDKIGAMLPCNVIVQQVDDGVEVAAVDPLASMQAVDNKDLAVIAEEIQSKLESVIEGL
>NC_014759.1|WP_013454231.1|2484383_2486684_-|multicopper-oxidase-domain-containing-protein
MQIKNSLTIIILFILTGFTASAQIDTTVYNLTIRQETVNKAGKEVVGMTVNGDIPGPTMRFKEGDYAIIYVKNEMEEETSVHWHGLLLPNFYDGVPYLTTPPIHPGETQKYEFPLIQSGTYWYHSHTMLQEQSGVYGSIVIDPKEGETLEYDKELVMVLSDWTNQKPMNVLRNLKRGNEWYNIKKGTATPLNRVIARGAFGAQLNFWRQRMESADIADIYYPAFLTNGEQAQEYPQFEPGEKVRLRIINGSASSQYWMTFGGKAPLLVAADGLNVVPVKHNKTFIGIAETYDFIVTIPEKGKIEFRATAQDGSGYTSAFLGKGEVIVAPEVERPDKIGMMKQMAQMDMRMGAPAMKFNPAEEEPHELMKNWGMQMDDEMNMEMNQDMKSDKVDSRMEEMDHSQMELENDKNMKKASSKNQIRGMDMFSEYNYDYLKAPSSTVIDEDKPVRDVLLNLTGNMWRYIWSMNGVPLSEADMIKISKGEKVRITFNNLTMMHHPMHFHGHFFRVINKHGEYSPLKHTVNVPPMQKTVIEFDAIEDSDWFLHCHVLYHMIGGMARAVSYDTERDPRMAKYPAKNLFKEGNRFYNWGMVDVASHMTELNLVSSNIRNQFNLNTEVGYNENMEAEFTYERYLYDYFRVFAGVNLENETENSLDEISATAIAGIRFFTPYMFNLDVRVDNKLRPEIRISREIMIFPRTAIFGNYEYQADFGWVNTLTDEGTNEPIDYKGETTWSAGVEYFLSRNFSLMGSYDNRFGAGGGLSIRF
>NC_014759.1|WP_013454232.1|2486838_2487408_-|helix-turn-helix-domain-containing-protein
MKTKLHIKNMVCPRCIMVVENELKTLGAKVRDVKLGYADVIIPATLTLEQIDLQMKKFGFELIHDPEGILTEQIKIVILDYLKHVHSKGKGAKKLSEYISLQIGRNYNYLSKVFSKQTGDTLEKYYINLRVEKVKELLDYNELNVSEIAVNLGYSSVHYLSNQFKNVTGFSISDYKKKSGTDRTFLDGL
>NC_014759.1|WP_013454233.1|2487397_2487799_-|hypothetical-protein
MDRQSILILSIFGAIIIAALFRSFSFNFSQIPVDISEEEQIPNELVCMVNDAFMGIEQIPVEADGKTYYGCCQMCVSKILENTGNVRYTTDPYSGEKVDKAVAFITLKPGQGKEVLYFISKNNMEAYLKKDEN
>NC_014759.1|WP_013454234.1|2487928_2488351_-|hypothetical-protein
MKTTKIILTAVMGLSISLYSCNDDDMQNKLSEDDIVALEGFREAYTRASDANLELKGSIQQGDFDGIHFHDSVFHHYEGLFEEHHEDYSHSNDHDDHHHDADGMHMGSNAMNGHDQGDGHHDDDHQSMDDLMDDHETSTH
>NC_014759.1|WP_148230154.1|2488362_2488851_-|DUF3347-domain-containing-protein
MALVSYGAFAQHDHGNHDDQKGMGQKMEPMFKDKDLGIAYGHYIHLKEALVASQMNEVRKAATKLEASLVSVDSGQEAKAEAANVVSAATLDGQRKAFASLSNEMSTLVKGGELSMGEIYLEYCPMANENTGAYWLSSEKEIKNPYFGDKMLKCGSVKETIN
>NC_014759.1|WP_013454236.1|2489037_2490828_-|efflux-RND-transporter-periplasmic-adaptor-subunit
MNTNKKIIIIALSTLAIGLLLGWLIFGGSSSESKMDDEHQHTTEIAGETVWTCSMHPQIRQGEPGDCPICGMDLIPLDNDDGEELDPMAVSMSPTAMQLADIRTAAVGTMDPVKSVRLNGKVQEDERLVFSQSSHIPGRIEKLMVNFTGEFVRKGQAIAYIYSPDLVTAQEELFEAQKIKDTQPQLFNSAKEKLKNWKLSDSQVEQILKVGTPKEEFAVQADVSGYVTEKMVNLGDYIRKGEAIYEIADLSKVWVLFDVYESDMPWIKKGDKVNFTVASLPGETFEGKITFLDPVIDPKTRVAKARVEVPNKDNQLKPEMFASGTVEATLPKKSNNIVVPKTAVMWTGKRSVVYVKNTTSSGVSFMMRDVTLGPGLGDSFIVESGLEEGEEIAVNGTFSIDAAAQLAGKPSMMNPEGGPAMTGHNHGGMDTPASSGQVNKKETKPVSISQKAKEALRPLYTEYLKFKDALTADEFDQAQKAASDLKTTLDKVNMAAFTGESHNAWMSHSSDLKNALQHVQHLKTIAELRTTFQQVSEGMIAMTKAFKPMDQTLYVQFCPMADDNKGANWLSTEEEIRNPYFGESMLTCGEVQENIK

Crispr_ID: NC_014759_1

• CRISPR_ID: NC_014759_1
• CRISPR_location: 2482558-2482806
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 4 spacers

Consensus repeat of NC_014759_1

Consensus_repeat	Method
TCCATCATTTTCTCCATCATTTG	CRISPRCasFinder

spacers of NC_014759_1

>1.1|2482581|40|NC_014759|CRISPRCasFinder
ATTCCCCTTCATCATTGAACTTTTGTCCATCATGCCTTTG
>1.2|2482644|19|NC_014759|CRISPRCasFinder
CTTCATCATTTCGGGATTA
>1.3|2482686|55|NC_014759|CRISPRCasFinder
GTCGTGGTGTTTTTCCATCAACTGTTGCATCATCATGTCTTTCATGGATTTATCT
>1.4|2482764|19|NC_014759|CRISPRCasFinder
TTTTCTACCCTCTTTGTCA

CRISPR arrays and Neighbor proteins around NC_014759_1

CRISPR arrays

The CRISPR arrays of NC_014759_1

>merge|NC_014759|1|2482558-2482806|CRISPRCasFinder
TCTTTCATTTTATCCATCATTTCATTCCCCTTCATCATTGAACTTTTGTCCATCATGCCTTTGTCATGCATTTTTTGCATCATCTTCTTCATCATTTCGGGATTATCCATCATTTTCTCCATCATTTGGTCGTGGTGTTTTTCCATCAACTGTTGCATCATCATGTCTTTCATGGATTTATCTCCCATCATTTTCTCCATCATTTGTTTTCTACCCTCTTTGTCACCCATCATGTTTTCCATCATCATC

>NC_014759|1|1|2482558-2482806|CRISPRCasFinder
TCTTTCATTTTATCCATCATTTC	ATTCCCCTTCATCATTGAACTTTTGTCCATCATGCCTTTG
TCATGCATTTTTTGCATCATCTT	CTTCATCATTTCGGGATTA
TCCATCATTTTCTCCATCATTTG	GTCGTGGTGTTTTTCCATCAACTGTTGCATCATCATGTCTTTCATGGATTTATCT
CCCATCATTTTCTCCATCATTTG	TTTTCTACCCTCTTTGTCA
CCCATCATGTTTTCCATCATCATC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_014759.1|WP_013454219.1|2474229_2474889_-|hypothetical-protein	unknown	unknown	unknown
NC_014759.1|WP_041650609.1|2474984_2475287_-|hypothetical-protein	unknown	unknown	unknown
NC_014759.1|WP_013454226.1|2481035_2481722_-|rhodanese-like-domain-containing-protein	unknown	unknown	gnl|CDD|238089
NC_014759.1|WP_148230154.1|2488362_2488851_-|DUF3347-domain-containing-protein	unknown	unknown	gnl|CDD|378730
NC_014759.1|WP_013454222.1|2477005_2477524_-|hypothetical-protein	unknown	unknown	unknown
NC_014759.1|WP_041649737.1|2483431_2483674_-|DUF302-domain-containing-protein	unknown	unknown	gnl|CDD|269820
NC_014759.1|WP_013454232.1|2486838_2487408_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|225117
NC_014759.1|WP_049784106.1|2475333_2476494_-|permease	unknown	unknown	gnl|CDD|281730
NC_014759.1|WP_013454236.1|2489037_2490828_-|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl|CDD|379862
NC_014759.1|WP_041649740.1|2483706_2483895_-|hypothetical-protein	unknown	unknown	unknown
NC_014759.1|WP_148230070.1|2476748_2476970_-|hypothetical-protein	unknown	unknown	unknown
NC_014759.1|WP_013454231.1|2484383_2486684_-|multicopper-oxidase-domain-containing-protein	unknown	unknown	gnl|CDD|273649
NC_014759.1|WP_013454233.1|2487397_2487799_-|hypothetical-protein	unknown	unknown	unknown
NC_014759.1|WP_013454230.1|2483904_2484291_-|DUF302-domain-containing-protein	unknown	unknown	gnl|CDD|269820
NC_014759.1|WP_013454223.1|2477527_2479222_-|multicopper-oxidase-domain-containing-protein	unknown	unknown	gnl|CDD|259946
NC_014759.1|WP_081457048.1|2482113_2482362_-|YHS-domain-containing-protein	unknown	unknown	gnl|CDD|225886
NC_014759.1|WP_013454225.1|2480693_2480906_-|SHOCT-domain-containing-protein	unknown	unknown	gnl|CDD|225993
NC_014759.1|WP_013454224.1|2479373_2480690_-|APC-family-permease	unknown	unknown	gnl|CDD|223605
NC_014759.1|WP_013454234.1|2487928_2488351_-|hypothetical-protein	unknown	unknown	unknown
NC_014759.1|WP_148230153.1|2483195_2483393_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_014759.1|WP_049784106.1|2475333_2476494_-|permease	gnl|CDD|281730	pfam03773, ArsP_1, Predicted permease. This family of integral membrane proteins are predicted to be permeases of unknown specificity.	1.41704e-46
NC_014759.1|WP_148230154.1|2488362_2488851_-|DUF3347-domain-containing-protein	gnl|CDD|378730	pfam11827, DUF3347, Protein of unknown function (DUF3347). This family of proteins are functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 169 to 570 amino acids in length.	5.28331e-48
NC_014759.1|WP_041649737.1|2483431_2483674_-|DUF302-domain-containing-protein	gnl|CDD|269820	cd14797, DUF302, Uncharacterized domain family DUF302. These domains are mostly found in bacterial single-domain proteins and have been shown to form homodimers; they may also bind zinc. Also characterized as COG3439.	5.86822e-12
NC_014759.1|WP_013454232.1|2486838_2487408_-|helix-turn-helix-domain-containing-protein	gnl|CDD|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	1.08812e-16
NC_014759.1|WP_013454231.1|2484383_2486684_-|multicopper-oxidase-domain-containing-protein	gnl|CDD|273649	TIGR01480, unnamed_protein_product, copper-resistance protein, CopA family. This model represents the CopA copper resistance protein family. CopA is related to laccase (benzenediol:oxygen oxidoreductase) and L-ascorbate oxidase, both copper-containing enzymes. Most members have a typical TAT (twin-arginine translocation) signal sequence with an Arg-Arg pair. Twin-arginine translocation is observed for a large number of periplasmic proteins that cross the inner membrane with metal-containing cofactors already bound. The combination of copper-binding sites and TAT translocation motif suggests a mechansism of resistance by packaging and export. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds].	1.96429e-119
NC_014759.1|WP_013454236.1|2489037_2490828_-|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl|CDD|379862	pfam16576, HlyD_D23, Barrel-sandwich domain of CusB or HlyD membrane-fusion. HlyD_D23 is the combined domains 2 and 3 of the membrane-fusion proteins CusB and HlyD, which forms a barrel-sandwich. CusB and HlyD proteins are membrane fusion proteins of the CusCFBA copper efflux system in E.coli and related bacteria. The whole molecule hinges between D2 and D3. Efflux systems of this resistance-nodulation-division group - RND - have been developed to excrete poisonous metal ions, and in E.coli the only one that deals with silver and copper is the CusA transporter. The transporter CusA works in conjunction with a periplasmic component that is a membrane fusion protein, eg CusB, and an outer-membrane channel component CusC in a CusABC complex driven by import of protons.	1.4926e-91
NC_014759.1|WP_013454223.1|2477527_2479222_-|multicopper-oxidase-domain-containing-protein	gnl|CDD|259946	cd13879, CuRO_2_McoP_like, The second cupredoxin domain of multicopper oxidase McoP and similar proteins. This family includes archaeal and bacterial multicopper oxidases (MCOs), represented by the extremely thermostable McoP from the hyperthermophilic archaeon Pyrobaculum aerophilum. McoP is an efficient metallo-oxidase that catalyzes the oxidation of cuprous and ferrous ions. It is noteworthy that McoP has three-fold higher catalytic efficiency when using nitrous oxide as electron acceptor than when using dioxygen, the typical oxidizing substrate of multicopper oxidases. McoP may function as a novel archaeal nitrous oxide reductase that is probably involved in the denitrification pathway in archaea. Although MCOs have diverse functions, majority of them have three cupredoxin domain repeats that include one mononuclear and one trinuclear copper center. The copper ions are bound in several sites: Type 1, Type 2, and/or Type 3. The ensemble of types 2 and 3 copper is called a trinuclear cluster. MCOs oxidize their substrate by accepting electrons at a mononuclear copper center and transferring them to the active site trinuclear copper center. The cupredoxin domain 2 of 3-domain MCOs has lost the ability to bind copper.	7.92461e-81
NC_014759.1|WP_081457048.1|2482113_2482362_-|YHS-domain-containing-protein	gnl|CDD|225886	COG3350, COG3350, Uncharacterized conserved protein [Function unknown].	3.52808e-11
NC_014759.1|WP_013454225.1|2480693_2480906_-|SHOCT-domain-containing-protein	gnl|CDD|225993	COG3462, COG3462, Predicted membrane protein [Function unknown].	8.38678e-08
NC_014759.1|WP_013454224.1|2479373_2480690_-|APC-family-permease	gnl|CDD|223605	COG0531, PotE, Amino acid transporters [Amino acid transport and metabolism].	1.20472e-27
NC_014759.1|WP_013454226.1|2481035_2481722_-|rhodanese-like-domain-containing-protein	gnl|CDD|238089	cd00158, RHOD, Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and certain stress proteins such as senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions (no active site cysteine) are also seen in dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases, where they are believed to play a regulatory role in multidomain proteins.	8.35784e-11
NC_014759.1|WP_013454230.1|2483904_2484291_-|DUF302-domain-containing-protein	gnl|CDD|269820	cd14797, DUF302, Uncharacterized domain family DUF302. These domains are mostly found in bacterial single-domain proteins and have been shown to form homodimers; they may also bind zinc. Also characterized as COG3439.	4.68721e-43

Protein sequences

>NC_014759.1|WP_081457048.1|2482113_2482362_-|YHS-domain-containing-protein
MDPTCGIVVNEHTAISYSYQGTIYYFDTEECLSVFKKNPNKFIKDSRGNWNVNASHMGWWLPATGGIMVVGMTLAMILGLNH
>NC_014759.1|WP_013454226.1|2481035_2481722_-|rhodanese-like-domain-containing-protein
MEISIAATKTCPHRPILENELKHARLPFKVIYFDEHPELLEKYQLKHSPLLIVDEQVESIGMPGMEKIEELKTRNVDLSQIRIPKRDNNHMIPNRVKAEPGLVEVDTTWGSIQPMQVAHGVLTVEELKVHYHQKMNLPIIDARKPDTNDAISIAGSKNIPFDEVVKRIDEIDKNHPSIFFCNGPQCPQSSTAIKNLLKAGYPADKILYYRGGMHDWITLGLPVEEISV
>NC_014759.1|WP_013454225.1|2480693_2480906_-|SHOCT-domain-containing-protein
MMYGWIIGVILIVVLIVALGRGGIFQKNSGETADSHHDDSAMETLKNRYARGEIDKAEFEEKKAELKKTK
>NC_014759.1|WP_013454224.1|2479373_2480690_-|APC-family-permease
MGKYKKNSLSLTGAISLGTGVMIGAAIFALLGQVAELSGSLFPIAFLVGAIIAGFSAYAYIKMSNAYPSAGGIAMYLKKAYGKGITTAVAALLMAFAMVINQSLVARTFGSYTMQLFDGNQNDFWIPLLGVILLVITFLINLAGNKVIDRVSFFMAIIKVGGIAIFAIGGLWAAGFSFGEAIPSEISGDYSVGSYLGALALAILAYAGFTTITNSGEEIVEPHKNVGRAIWISLIICTIVYLLVAFAVSVNLSVPKIIEAKDYSLAEAARPAFGKYGLWFTVGIAIIATVSSVLANVFAISRMTTMLTEMKLIPHKHFGMPGNLQQHMLTYTIVIAIALTIFFDLSRIASLGAIFYLIMDIIIQWGVFKHLRKEIKANGAILLATIVLDVVVLAAFIWMKAQSDMLLIIVSAVLLTLIIAGEKWFLKMRKFKVESSNN
>NC_014759.1|WP_013454223.1|2477527_2479222_-|multicopper-oxidase-domain-containing-protein
MKEPFRINRRKFLAKAGAGAAVTMIWPFFSSCDSQSSTTAKPKLSKDFQPDIDLELKAVQRDLSILPGSKTKVWVYEGKLIKGNKEALLPLQGSYLGPIIKVRKGQKVRIRFQNDLPEESIVHWHGMHVPERYDGHPQDVIDSGETYIYEYEVMNRAGTYWFHPHPHGRTGPQVYNGLAGLLLVTDEEEQQLNLPQGEFDLPVVIQDRTFDDNNQLVYLENGQMGRMTGFLGNRILINGRPEQRLNLKAGCKYRLRLLNGSNSRIYKLAWEDGSPVTVFGMDGSLLNAPKELSYLMLGPAKRADVWLDLTNKPEGTELTMKNTSFPLELMSGGMMGNGGMMEGAKSVLPQGSEYPVFTVLANASGSNDYTLPRQLAQPDYIDPSTAGNLNAPRQFTFAMGHMEWTINGRTWETTEVADEEIVKLGSIEVWELINGGGMMDNDDDGGGMMDGHGTMDNGGMMRGDDGMMSGGGMMGNMMQMPHPIHIHQVQFNILERNVTDVDPQLWDAVKDGFVDEGWHDTVLLMPGMSAKVIMQFKDFKGLFVYHCHNLEHEDMGMMRNFKIV
>NC_014759.1|WP_013454222.1|2477005_2477524_-|hypothetical-protein
MDNLSFGIFVVPIITLTLIIMLYIHFFRKAADKRNYQYFVARTSVVAFVLNFGWEVAHGFLYENFQYDLEHVSFCALASIADVLMVLVLLFLFGLIYNNVYWIRRLKFTRTLLLVLVGFLGAILGEFWHTWRGDWSYADTMPMLPLIEVGLSPVLQFSILPLIIFLISRRKI
>NC_014759.1|WP_148230070.1|2476748_2476970_-|hypothetical-protein
MKHEKQAKLNKVKGQIGYAMMWFFLAGLIETLMYLGKIEMFIYHIVALALSAVGCFKVFKGFENYKHYKNEGK
>NC_014759.1|WP_049784106.1|2475333_2476494_-|permease
MGFFWKSGWAFVLGYIISSMIQAFVPKKKLTQQMGKGNVKSISLSTLFGSISSSCSFAALAAARSLFQKGAHFISTVAFMFASTNLVIELGILIFIFLGWQFIVAEVIGGLILITISGLIIKLTSPKKWIKAAREKVEDESAEEEDFDWKERIKSKEGWFLVGKKFVMEWKMAWEDILIGFTIAGFVSVLVPQSFWEAIFLNGMQGELPDFVIRLENALVAPFVAAATFIGSMGNIPLATVLNENGILFAGLMGFIYSDLMVPPLVNMNRKYYGTRIALYIAGVMYVSIVITALILNYSFDLLGVLPEGSRKVKEVTQFKIDYTFYFNIVFAAFTALMLYFNFRTKKMETDGGHDHEHGGGGISFKRVVVYTFVLIVGIGLVIFLL
>NC_014759.1|WP_041650609.1|2474984_2475287_-|hypothetical-protein
MKTYETLSEALKDLKERGYSNDFNLKPHCIECPADKLELHPEQFEVKEVYRFEGMSNPDDNSILYAIKSTDGLKGVLVDAYGVYSEALSEAMINKLVVNR
>NC_014759.1|WP_013454219.1|2474229_2474889_-|hypothetical-protein
MKKLGLLLYFMLSCIVLSAHEGEKHEKSTKEDSTHLEQPQVDYSHIQAQQEHEHDEHETKKVTADLDDFPNLHPLMVHFPIVLLLIGAVLAIVNVILLKKEVDWVITGMVLVGALGAYLSGRTFHPHTHDLTEHAKQVLAQHDLWADWTIYLSIAGFVAQAVSQFIFRQKRWAVAVVALLLIASGYVVSRTGHYGAQLVHIEAVGPQGKFLESEEGHAH
>NC_014759.1|WP_148230153.1|2483195_2483393_-|hypothetical-protein
MLVGVFATACNNPGGNGNQDHGDVMEDNQTEMMEGDNDHMHEDGQSDEHIMSDTTSMDMNDEMER
>NC_014759.1|WP_041649737.1|2483431_2483674_-|DUF302-domain-containing-protein
MCNAALAIDALSVENKVGIMLPCNIIIQETGEEGVLEVAVTDPLAALEIADNGKLKSLGKRAKDQLQKALNEVEHQNNKL
>NC_014759.1|WP_041649740.1|2483706_2483895_-|hypothetical-protein
MSDKNKIAKENYKESMETSYCISKRFGSMTFQEAIDYSKKAFENNGFEVVMHFDLQNHIKKN
>NC_014759.1|WP_013454230.1|2483904_2484291_-|DUF302-domain-containing-protein
MKYYHEKTLKGVSFEEAIQKVTDALKEEGFGILTEIDVKETLKKKLDEDFRPYKILGACNPPFAHKALLAEDKIGAMLPCNVIVQQVDDGVEVAAVDPLASMQAVDNKDLAVIAEEIQSKLESVIEGL
>NC_014759.1|WP_013454231.1|2484383_2486684_-|multicopper-oxidase-domain-containing-protein
MQIKNSLTIIILFILTGFTASAQIDTTVYNLTIRQETVNKAGKEVVGMTVNGDIPGPTMRFKEGDYAIIYVKNEMEEETSVHWHGLLLPNFYDGVPYLTTPPIHPGETQKYEFPLIQSGTYWYHSHTMLQEQSGVYGSIVIDPKEGETLEYDKELVMVLSDWTNQKPMNVLRNLKRGNEWYNIKKGTATPLNRVIARGAFGAQLNFWRQRMESADIADIYYPAFLTNGEQAQEYPQFEPGEKVRLRIINGSASSQYWMTFGGKAPLLVAADGLNVVPVKHNKTFIGIAETYDFIVTIPEKGKIEFRATAQDGSGYTSAFLGKGEVIVAPEVERPDKIGMMKQMAQMDMRMGAPAMKFNPAEEEPHELMKNWGMQMDDEMNMEMNQDMKSDKVDSRMEEMDHSQMELENDKNMKKASSKNQIRGMDMFSEYNYDYLKAPSSTVIDEDKPVRDVLLNLTGNMWRYIWSMNGVPLSEADMIKISKGEKVRITFNNLTMMHHPMHFHGHFFRVINKHGEYSPLKHTVNVPPMQKTVIEFDAIEDSDWFLHCHVLYHMIGGMARAVSYDTERDPRMAKYPAKNLFKEGNRFYNWGMVDVASHMTELNLVSSNIRNQFNLNTEVGYNENMEAEFTYERYLYDYFRVFAGVNLENETENSLDEISATAIAGIRFFTPYMFNLDVRVDNKLRPEIRISREIMIFPRTAIFGNYEYQADFGWVNTLTDEGTNEPIDYKGETTWSAGVEYFLSRNFSLMGSYDNRFGAGGGLSIRF
>NC_014759.1|WP_013454232.1|2486838_2487408_-|helix-turn-helix-domain-containing-protein
MKTKLHIKNMVCPRCIMVVENELKTLGAKVRDVKLGYADVIIPATLTLEQIDLQMKKFGFELIHDPEGILTEQIKIVILDYLKHVHSKGKGAKKLSEYISLQIGRNYNYLSKVFSKQTGDTLEKYYINLRVEKVKELLDYNELNVSEIAVNLGYSSVHYLSNQFKNVTGFSISDYKKKSGTDRTFLDGL
>NC_014759.1|WP_013454233.1|2487397_2487799_-|hypothetical-protein
MDRQSILILSIFGAIIIAALFRSFSFNFSQIPVDISEEEQIPNELVCMVNDAFMGIEQIPVEADGKTYYGCCQMCVSKILENTGNVRYTTDPYSGEKVDKAVAFITLKPGQGKEVLYFISKNNMEAYLKKDEN
>NC_014759.1|WP_013454234.1|2487928_2488351_-|hypothetical-protein
MKTTKIILTAVMGLSISLYSCNDDDMQNKLSEDDIVALEGFREAYTRASDANLELKGSIQQGDFDGIHFHDSVFHHYEGLFEEHHEDYSHSNDHDDHHHDADGMHMGSNAMNGHDQGDGHHDDDHQSMDDLMDDHETSTH
>NC_014759.1|WP_148230154.1|2488362_2488851_-|DUF3347-domain-containing-protein
MALVSYGAFAQHDHGNHDDQKGMGQKMEPMFKDKDLGIAYGHYIHLKEALVASQMNEVRKAATKLEASLVSVDSGQEAKAEAANVVSAATLDGQRKAFASLSNEMSTLVKGGELSMGEIYLEYCPMANENTGAYWLSSEKEIKNPYFGDKMLKCGSVKETIN
>NC_014759.1|WP_013454236.1|2489037_2490828_-|efflux-RND-transporter-periplasmic-adaptor-subunit
MNTNKKIIIIALSTLAIGLLLGWLIFGGSSSESKMDDEHQHTTEIAGETVWTCSMHPQIRQGEPGDCPICGMDLIPLDNDDGEELDPMAVSMSPTAMQLADIRTAAVGTMDPVKSVRLNGKVQEDERLVFSQSSHIPGRIEKLMVNFTGEFVRKGQAIAYIYSPDLVTAQEELFEAQKIKDTQPQLFNSAKEKLKNWKLSDSQVEQILKVGTPKEEFAVQADVSGYVTEKMVNLGDYIRKGEAIYEIADLSKVWVLFDVYESDMPWIKKGDKVNFTVASLPGETFEGKITFLDPVIDPKTRVAKARVEVPNKDNQLKPEMFASGTVEATLPKKSNNIVVPKTAVMWTGKRSVVYVKNTTSSGVSFMMRDVTLGPGLGDSFIVESGLEEGEEIAVNGTFSIDAAAQLAGKPSMMNPEGGPAMTGHNHGGMDTPASSGQVNKKETKPVSISQKAKEALRPLYTEYLKFKDALTADEFDQAQKAASDLKTTLDKVNMAAFTGESHNAWMSHSSDLKNALQHVQHLKTIAELRTTFQQVSEGMIAMTKAFKPMDQTLYVQFCPMADDNKGANWLSTEEEIRNPYFGESMLTCGEVQENIK

Crispr_ID: NC_014759_3

• CRISPR_ID: NC_014759_3
• CRISPR_location: 4191408-4191507
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_014759_3

Consensus_repeat	Method
AAACATATAGCTCATATTGGTAACA	CRISPRCasFinder

spacers of NC_014759_3

>3.1|4191433|50|NC_014759|CRISPRCasFinder
TTAGAGATATCCCAATTAGTTAAATCCTGATTAAAAGAAGTAGCACTAGA

CRISPR arrays and Neighbor proteins around NC_014759_3

CRISPR arrays

The CRISPR arrays of NC_014759_3

>merge|NC_014759|3|4191408-4191507|CRISPRCasFinder
AAACATATAGCTCATATTGGTAACATTAGAGATATCCCAATTAGTTAAATCCTGATTAAAAGAAGTAGCACTAGAAAACATATAGCTCATATCGGTAACA

>NC_014759|3|3|4191408-4191507|CRISPRCasFinder
AAACATATAGCTCATATTGGTAACA	TTAGAGATATCCCAATTAGTTAAATCCTGATTAAAAGAAGTAGCACTAGA
AAACATATAGCTCATATCGGTAACA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_014759.1|WP_013455656.1|4185135_4185840_-|hypothetical-protein	unknown	unknown	unknown
NC_014759.1|WP_013455654.1|4183039_4183834_+|glutamate-5-kinase	unknown	unknown	gnl|CDD|239775
NC_014759.1|WP_013455664.1|4200350_4200632_-|N-acetyltransferase	unknown	unknown	gnl|CDD|379642
NC_014759.1|WP_041650890.1|4182217_4183024_+|pyrroline-5-carboxylate-reductase	unknown	unknown	gnl|CDD|237008
NC_014759.1|WP_013455662.1|4197234_4197732_-|histidine-phosphatase-family-protein	unknown	unknown	gnl|CDD|224973
NC_014759.1|WP_013455659.1|4187354_4189346_+|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|276809
NC_014759.1|WP_013455655.1|4183881_4185081_+|glutamate-5-semialdehyde-dehydrogenase	unknown	unknown	gnl|CDD|234685
NC_014759.1|WP_013455650.1|4176369_4177599_+|alanine-dehydrogenase	unknown	unknown	gnl|CDD|240630
NC_014759.1|WP_013455669.1|4207127_4208891_+|DUF1800-domain-containing-protein	unknown	unknown	gnl|CDD|378055
NC_014759.1|WP_013455651.1|4177595_4179659_-|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|225118
NC_014759.1|WP_041650896.1|4200750_4201572_+|DMT-family-transporter	unknown	unknown	gnl|CDD|223769
NC_014759.1|WP_013455667.1|4203282_4204101_+|3-methyl-2-oxobutanoate-hydroxymethyltransferase	unknown	unknown	gnl|CDD|234723
NC_014759.1|WP_013455668.1|4204701_4206933_+|NADP-dependent-isocitrate-dehydrogenase	unknown	unknown	gnl|CDD|377178
NC_014759.1|WP_013455661.1|4196154_4197228_-|agmatinase-family-protein	unknown	unknown	gnl|CDD|212539
NC_014759.1|WP_013455658.1|4186630_4187170_-|lvivd-repeat-containing-protein	unknown	unknown	gnl|CDD|293789
NC_014759.1|WP_013455652.1|4179795_4181829_-|copper-translocating-P-type-ATPase	unknown	unknown	gnl|CDD|319850
NC_014759.1|WP_013455666.1|4201741_4203274_+|PAS-domain-containing-protein	unknown	unknown	gnl|CDD|223715
NC_014759.1|WP_013455663.1|4197868_4200226_+|type-I-DNA-topoisomerase	unknown	unknown	gnl|CDD|236048
NC_014759.1|WP_013455657.1|4185832_4186606_-|hypothetical-protein	unknown	unknown	gnl|CDD|293789
NC_014759.1|WP_013455670.1|4208893_4210594_+|DUF1501-domain-containing-protein	unknown	unknown	gnl|CDD|226587

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_014759.1|WP_013455654.1|4183039_4183834_+|glutamate-5-kinase	gnl|CDD|239775	cd04242, AAK_G5K_ProB, AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine) biosynthesis. G5K is subject to feedback allosteric inhibition by proline or ornithine. In microorganisms and plants, proline plays an important role as an osmoprotectant and, in mammals, ornithine biosynthesis is crucial for proper ammonia detoxification, since a G5K mutation has been shown to cause human hyperammonaemia. Microbial G5K generally consists of two domains: a catalytic G5K domain and one PUA (pseudo uridine synthases and archaeosine-specific transglycosylases) domain, and some lack the PUA domain. G5K requires free Mg for activity, it is tetrameric, and it aggregates to higher forms in a proline-dependent way. G5K lacking the PUA domain remains tetrameric, active, and proline-inhibitable, but the Mg requirement and the proline-triggered aggregation are greatly diminished and abolished, respectively, and more proline is needed for inhibition. Although plant and animal G5Ks are part of a bifunctional polypeptide, delta 1-pyrroline-5-carboxylate synthetase (P5CS), composed of an N-terminal G5K (ProB) and a C-terminal glutamyl 5- phosphate reductase (G5PR; ProA); bacterial and yeast G5Ks are monofunctional single-polypeptide enzymes. In this CD, all three domain architectures are present: G5K, G5K+PUA, and G5K+G5PR.	3.92865e-87
NC_014759.1|WP_013455664.1|4200350_4200632_-|N-acetyltransferase	gnl|CDD|379642	pfam14542, Acetyltransf_CG, GCN5-related N-acetyl-transferase. This family of GCN5-related N-acetyl-transferases bind both CoA and acetyl-CoA. They are characterized by highly conserved glycine, a cysteine residue in the acetyl-CoA binding site near the acetyl group, their small size compared with other GNATs and a lack of of an obvious substrate-binding site. It is proposed that they transfer an acetyl group from acetyl-CoA to one or more unidentified aliphatic amines via an acetyl (cysteine) enzyme intermediate. The substrate might be another macromolecule.	1.29391e-20
NC_014759.1|WP_041650890.1|4182217_4183024_+|pyrroline-5-carboxylate-reductase	gnl|CDD|237008	PRK11880, PRK11880, pyrroline-5-carboxylate reductase; Reviewed.	9.0214e-81
NC_014759.1|WP_013455662.1|4197234_4197732_-|histidine-phosphatase-family-protein	gnl|CDD|224973	COG2062, SixA, Phosphohistidine phosphatase SixA [Signal transduction mechanisms].	3.19837e-27
NC_014759.1|WP_013455659.1|4187354_4189346_+|tetratricopeptide-repeat-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	2.42808e-14
NC_014759.1|WP_013455655.1|4183881_4185081_+|glutamate-5-semialdehyde-dehydrogenase	gnl|CDD|234685	PRK00197, proA, gamma-glutamyl phosphate reductase; Provisional.	2.86795e-158
NC_014759.1|WP_013455650.1|4176369_4177599_+|alanine-dehydrogenase	gnl|CDD|240630	cd05305, L-AlaDH, Alanine dehydrogenase NAD-binding and catalytic domains. Alanine dehydrogenase (L-AlaDH) catalyzes the NAD-dependent conversion of pyruvate to L-alanine via reductive amination. Like formate dehydrogenase and related enzymes, L-AlaDH is comprised of 2 domains connected by a long alpha helical stretch, each resembling a Rossmann fold NAD-binding domain. The NAD-binding domain is inserted within the linear sequence of the more divergent catalytic domain. Ligand binding and active site residues are found in the cleft between the subdomains. L-AlaDH is typically hexameric and is critical in carbon and nitrogen metabolism in micro-organisms.	0
NC_014759.1|WP_013455669.1|4207127_4208891_+|DUF1800-domain-containing-protein	gnl|CDD|378055	pfam08811, DUF1800, Protein of unknown function (DUF1800). This is a family of large bacterial proteins of unknown function.	2.43558e-95
NC_014759.1|WP_013455651.1|4177595_4179659_-|tetratricopeptide-repeat-protein	gnl|CDD|225118	COG2208, RsbU, Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription].	2.61751e-15
NC_014759.1|WP_041650896.1|4200750_4201572_+|DMT-family-transporter	gnl|CDD|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	4.06885e-11
NC_014759.1|WP_013455667.1|4203282_4204101_+|3-methyl-2-oxobutanoate-hydroxymethyltransferase	gnl|CDD|234723	PRK00311, panB, 3-methyl-2-oxobutanoate hydroxymethyltransferase; Reviewed.	2.48755e-164
NC_014759.1|WP_013455668.1|4204701_4206933_+|NADP-dependent-isocitrate-dehydrogenase	gnl|CDD|377178	pfam03971, IDH, Monomeric isocitrate dehydrogenase. NADP(+)-dependent isocitrate dehydrogenase (ICD) is an important enzyme of the intermediary metabolism, as it controls the carbon flux within the citric acid cycle and supplies the cell with 2-oxoglutarate EC:1.1.1.42 and NADPH for biosynthetic purposes.	0
NC_014759.1|WP_013455661.1|4196154_4197228_-|agmatinase-family-protein	gnl|CDD|212539	cd11593, Agmatinase-like_2, Agmatinase and related proteins. This family includes known and predicted bacterial and archaeal agmatinase (agmatine ureohydrolase; AUH; SpeB; EC=3.5.3.11), a binuclear manganese metalloenzyme that belongs to the ureohydrolase superfamily. It is a key enzyme in the synthesis of polyamine putrescine; it catalyzes hydrolysis of agmatine to yield urea and putrescine, the precursor for biosynthesis of higher polyamines, spermidine, and spermine. As compared to E. coli where two paths to putrescine exist, via decarboxylation of an amino acid, ornithine or arginine, a single path is found in Bacillus subtilis, where polyamine synthesis starts with agmatine; the speE and speB encode spermidine synthase and agmatinase, respectively. The level of agmatinase synthesis is very low, allowing strict control on the synthesis of putrescine and therefore, of all polyamines, consistent with polyamine levels in the cell. This subfamily belongs to the ureohydrolase superfamily, which includes arginase, agmatinase, proclavaminate amidinohydrolase, and formiminoglutamase.	3.36211e-100
NC_014759.1|WP_013455658.1|4186630_4187170_-|lvivd-repeat-containing-protein	gnl|CDD|293789	sd00042, LVIVD, LVIVD repeat. LVIVD repeats are mainly found in bacterial and archaeal cell surface proteins, many of them hypothetical. Structurally, LVIVD repeats have been predicted to form a beta-propeller, with each repeat forming one four-stranded anti-parallel beta-sheet blade.	7.84971e-14
NC_014759.1|WP_013455652.1|4179795_4181829_-|copper-translocating-P-type-ATPase	gnl|CDD|319850	cd07552, P-type_ATPase_Cu-like, P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+)-ATPase. Archaeoglobus fulgidus CopB transports Cu(2+) from the cytoplasm to the exterior of the cell using ATP as energy source, it transports preferentially Cu(2+) over Cu(+), it is activated by Cu(2+) with high affinity and partially by Cu(+) and Ag(+). This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NC_014759.1|WP_013455666.1|4201741_4203274_+|PAS-domain-containing-protein	gnl|CDD|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	4.44577e-42
NC_014759.1|WP_013455663.1|4197868_4200226_+|type-I-DNA-topoisomerase	gnl|CDD|236048	PRK07561, PRK07561, DNA topoisomerase I subunit omega; Validated.	0
NC_014759.1|WP_013455657.1|4185832_4186606_-|hypothetical-protein	gnl|CDD|293789	sd00042, LVIVD, LVIVD repeat. LVIVD repeats are mainly found in bacterial and archaeal cell surface proteins, many of them hypothetical. Structurally, LVIVD repeats have been predicted to form a beta-propeller, with each repeat forming one four-stranded anti-parallel beta-sheet blade.	7.21504e-23
NC_014759.1|WP_013455670.1|4208893_4210594_+|DUF1501-domain-containing-protein	gnl|CDD|226587	COG4102, COG4102, Uncharacterized protein conserved in bacteria [Function unknown].	8.16515e-45

Protein sequences

>NC_014759.1|WP_013455659.1|4187354_4189346_+|tetratricopeptide-repeat-protein
MFKAATKYIIYTLFFSCFFVNSLDLYAQRKGNKKDSTEVIRLNNLFKIKYASEPSKSFTYATSALEISRKISFLKGEATANNNLGVYHKQKGDYDQALRYFKEALNLYDSLREKSGAAKALSNIGNIYSINQDFERALDYYSDAKIIFEELNDSSRLLRILNNIGNIYLDNGQEKEAIDYYRRVLEIYQVSDDKTNLFDPFSNIGKIYFNQQQYDSALYYFNKSLKKEEAADNKFGISGSLVKISRLHNARGNHLAARDAALDAVEIAQNINAKPILLDAYSTLAEVYLHLNDLENSYVYMNQFHIMNDSLFNEKSRRSIAELEKSIELEQKEKEIALLKKESEIKDLQYQNSRLYIYGSIGFSILLLALAIISFLKFKQNRKAKSLLEYQNREILKSKKAIEIQKMKLESWNQNITDSIEYAKSIQEGIMNKNNFKENLTASFVFYKPKDIVSGDFYWYSRQKGCDILALIDCTGHGVAGAFMTVIANATMNQIVNEEKEIEPNKILTKLDIKVMEILKQKEVTKTNHSMDVALCKIDYENKVVTFSGAKRPLYVVEHNKLREFKGNNFTVGEYFNTPEKKFTYQEIDFEENQTYYLSSDGFADQFGFNTQKKYLRKRFKTLLESISNKSLPEQRKSLEMEMKRWQGEMEQTDDMLVIGFRV
>NC_014759.1|WP_013455658.1|4186630_4187170_-|lvivd-repeat-containing-protein
MSYTTKLLTLGFILLAMSSCDNWERVPDFDVEQVEGYRPIYATESEQKVKNLPARKIENPGKIYTINDFLLVVDQLKGIHVFDNNNPENPQNVGFIQITGSNDVAVRDNILYADQATDLLAIDISNPENVQIASRVKNVFPFGSQYPQQQGVYFECPDPDKGLVIGWEYTTLNSPKCYR
>NC_014759.1|WP_013455657.1|4185832_4186606_-|hypothetical-protein
MKITKLSIIPILTFLAVLITFSSCDSDTEFDSSGEGKGGSMARFTFLKGYLYIVDESTLKTFDISNPENPTLLGTEEVGAGVETIFPYENYLFLGTQWGMKIYSVENGPTPNFMSDFEHSFSCDPVVVSNSIAYVTLRSGTTCQTGQDRMEVVDVSDLRNPELLTTIPMENPHGLSVSDTVLFVCEGDFGFKVFNIKDRSNPELISHYDSIPSYDVITNYGRKELIITGKKGIFQYDYKNPYELKELSQILSFPENE
>NC_014759.1|WP_013455656.1|4185135_4185840_-|hypothetical-protein
MNRLLTITIFFFFIFHNLTAQNQESDSLKRSNLNKITPYISLTSAFEKYSSFDIGFSKPTKNGNSIGMDLGYIYDISAFNTEIPDSWYQNTYGVKAYFYYRIFINESDPYPLNSKIFIDIEPQIFWASFESERIAGYSCNEDWGDCEYYRFFDSRVDRLIPGLNFKLGKIYKYDPLQFTLFMGFGIRHVIEFSDLMNDPAPDKIFNKRGEMSNLGTGTLLNLRLGFQVGYNFWN
>NC_014759.1|WP_013455655.1|4183881_4185081_+|glutamate-5-semialdehyde-dehydrogenase
MKLLNTEIKNAVLQSMIDNLDKNRDAIIAANKRDLDAFDRDDQALYDRLVVDSAKVDDMIRAVKEVKDQDDPVGTVISEDKLENGLHITNKAAPFGTIMIIYESRPDVTIEAAVLAFKANNKILLKGGKEAHHSNEELVKCWHQSLQDNGLAESWIQYLKMDRPTTQEFLRNPDQPLDLIVPRGGEKLIGFVKEHAKCAVLVSGRGNNFAYIAPDADMEKVIPVLINAKTDKISGCNALDKILVDENHPKFEETLRAIEKALTDKGVQIVASGKVIGQLETNEKIDNEDVWYEEFLAMKAAMTSVNGLDDAIDFINKYSGGHSNIILTETQADAEKFMEQIDSAAVYHNASTRFTDGGQMGVGAELAISTDKLHHRGPLGLKQLVTNKYYVLGNGQVRK
>NC_014759.1|WP_013455654.1|4183039_4183834_+|glutamate-5-kinase
MKTHSKRIVVKIGTNVMTNKDNRIVVPILKRIVDQVARLYEEDVMTVLISSGSVIAGKEVLDDNEIDTIDNAAQRRQVYSAVGQPRMMRHYYSIFHDYGMRCAQVLATKRDFDFGRHRDNMINCYEGLLGQGIIPIANEDDAVSLSMSMFSDNDELASLVAELVDADALILLTDTDGIFDGHPDHDDSNVIKSVSTDQEVEQFIQESDKKEGEGRGGMESKINVAKGAASKDIVTYIANGKREDVIIDIVHGKDVGTRIYKEDE
>NC_014759.1|WP_041650890.1|4182217_4183024_+|pyrroline-5-carboxylate-reductase
MKVLVIGAGNMGLAYAKALVKSEFLSNHNLMISDTSAEKTEELKKISRFDVFTNLSDCLPKADIIFIAVKPYHTDELFEELKPMMSPDQIVISIMAGVTIQSMKDGLGITKVVRAMPNLPAQVGKGLTSFTASDEVSRLELSTVENLLDTTGRSVRLDTENDVDASTGISGSGPAYVFYFMHSMMEAAKKMGFSVHDSKVLVGTTFEGAVELFNKSDLSPEGWMKRVASKGGTTRAALDSMEDNNIKQLIEDAAYAAFNRAVELGKES
>NC_014759.1|WP_013455652.1|4179795_4181829_-|copper-translocating-P-type-ATPase
MSSNHQDAQHHHDHNDQNGHNHNEHDHHQHHAQMIEDFKKRFWISIIITIPIMVLAPMIQELLGYELRFQFDRYVQFALSTIVFFYCGYPFLKGLKDEIEDRKPGMMTLIALAISVAYFYSSAVVFGLEGKIFFWELTSLITIMLLGHWIEMKSIMGASGAVEELAKLLPSTALKVDEKGDTHEVKISELEAGDLVLVKPGEKIPADGIIEKGKSDINESMITGESKPASKKEGDEVIGGSVNGSSSIQFKIKEDSEGSYLNKVVEMVKSAQETKSKTQNLANKAAAWLFYIALFSGFTTLGVWLWQGKEFDYALERMVTVMIIACPHALGLAMPLVVAISTSVSAQNGLLIRNRTAFENARNITTIIFDKTGTLTKGNFVVNQFKSTSSEYENKGILKMAASLERESEHPIATGIVKKHEEEKLDFHDISDFENLTGEGIQAKINGESIKVVSPGYLEENSIELPEDTKNEKAETIVYILKDKNLIGYISLADEIRDESYEAVKILKENGLKVIMATGDNKEVAKSVSKELGLDDYYAEVLPEDKQKIIEDLQEKGEIVAMTGDGVNDAPALAKADVGIAIGSGTDVAAETADIILVNSNPMDIVHLLAFGKSTYQKMMQNLFWAAGYNIVAIPMAAGALAFAGIILSPAVGAGLMSLSTIIVALNAQLLKRKMKN
>NC_014759.1|WP_013455651.1|4177595_4179659_-|tetratricopeptide-repeat-protein
MYKVFFIFLIFFNLTCVGQSIQELKEDLKNAKSDSQRMSLYYELSSEYQFNDNEKAISYAEQLLELAKKKKDTTNIVYGKAMIAYSYYNLGALDKSLKINLEAHEIAKTSKNEKLIDYIITHLALIYDEMGNYGKALEYYRYNIHYAKENDLPQDQMIGLLNIADMYVRMEEYDSAEYYAEKAIKFEEESEEYVRSIAYINYGVALEKNNKFDKALIYLLRGLEIQYTSSPDFAAISEAYVTISNIYVKKKQLINALQFADSSINSAKKSESNYYLRKGYELRSSIHKSLGDNAKAYNDLKKYVETNDKIYNEETTEKFLELQELYEAKQREAEINLLKQESELSKESITQKNIVIIGSLIILLLLALFLALYISRNRLKQKALTLLDAQKREIEERNFQLGEMTEELKSQKEEIETHRDQLSEAYGILEKRNQDVTDSINYAQKIQNSLLPDLKTIKKALPQSFIFYKARDIVSGDFYWFHQKSINGKDIKFIASIDCTGHGVPGAFMSMIADALLSQVIIELDYNEPAKILTEMDRRLRIMLKQDESYGNDGMEIGLCTIYDGKMEFSGAGHKLIYFENGDINILKDNRYSIGESFISHQKMNFTNHTISIDSPKMFYLFSDGIQDQFGGPKDKKLGIKHLRRNLTSIHQDSIHLQERHIKAMVENWKGTEEQVDDMLLIGFRLT
>NC_014759.1|WP_013455650.1|4176369_4177599_+|alanine-dehydrogenase
MAKEISRKGFDVLARKGALYPQEELLAVERGKNAMQIGIPNEISLQEKRVPLTPGAVALLSNNGHEVIVESGMGLSSNFTDNEYSDAGAKIVYSSKEAFEAQLVVKIEPPVKKEIEMFKPGSFLISALQVGQLNKEYFQLINEKRITAIGIELIEDKVGGMPMVRAMSEIAGISAIQIATELLSNLNNGKGIILGGITGVRPTKVVILGAGTVGEYAARAALGLGANIEIYDNHLYKLRRIKHAIGQPIHTSSMDTVMLSDSLTEADVLICAVRAEKGRSGCIVTEEMVMNMRKNAVIIDVSIDQGGCVETSEVTSHDNPTFKKYDVIHYCVPNIASRVSRTASNAVSNILTPMLLQAGDVGGIEEMIFTHSWFMKGVYTYKGSLTNMHIAKKFDLKYKELSLLMAARF
>NC_014759.1|WP_013455661.1|4196154_4197228_-|agmatinase-family-protein
MTKKQEIINAFDPNGIGNVDNIFALPFDEKTADLILIPVPWEVTVSYEAGTAQGPQHILEASTQVDLYQKDIIDAWKMGIQMLPINQDLLTKSNKHRIMAEEYIGLLESGEENSDKGKNLLKEVNSVCSEMVEWVKTESLKQLDKHKLLGLVGGDHSTPLGAVQALATNHETFGVLQIDAHMDFRKAYENFQYSHASISYNMLQTVPQIEKMVQVGIRDFCEEEIKFAEKQGERVSVFYDDDIKVGMFEGESWTIICDRIIKELPNEVYITFDIDGLRPELCPNTGTPVPGGISYSEIIYLLTRLVKNGKKIIGFDLNEVAPGENTDWNGNVGARILYRLCNLMGVSQGKLEWDESF
>NC_014759.1|WP_013455662.1|4197234_4197732_-|histidine-phosphatase-family-protein
MVKDLYLIRHGEAEEPTAGLKDVERQLTAKGLQDASKVGMYLKQKEFHPDLMLHSIAERTTQTMYRINEQLGVKTDHIEASEDVYEASARIMLRVISEIPAEMRSAIIICHNPSITYISEYITGSEVGYVEPAGMVHIQIPYSSWSEVSEKNCDLIEYIRPEDIQ
>NC_014759.1|WP_013455663.1|4197868_4200226_+|type-I-DNA-topoisomerase
MSKNLVIVESPAKAKTIEGYLGKDYKVLSSYGHVRDLPKGNNAIDIENGFKPTYEVSKDKKEVIKALIKEAKLAEMIYLATDDDREGEAISWHLKEALNLDDARTKRIVFREITKSAIQNAINSPKGIDIDLVNAQQARRILDRLVGFELSPILWKKIKTGLSAGRVQSVAVRIVVEREREIEKFKAESFFKIQAFFNVEGKELKAELPGRFKTEEEAMAFLEKCLDAEFSIGKLEKKPAKKTPAPPFTTSTLQQEASRKLGFSVSQTMTLAQRLYESGKISYMRTDSLNLSDEAKEGAAKEIKSEYGADYAHTRTFKTKSAGAQEAHEAIRPTNFATKEASSDYNEQRLYDLIWKRAIASQMSDAQIEKTNVSIDISNTDQTLSASGEVVKFEGFLKVYIESTDEEEEGETNVTKGMLPPLQVGQTLDLKRMQSREGFTRPPARYNEATLVKKLEEMGIGRPSTYAPTISTIQKRGYVNKEFRDGKDRKYVEMVLENGKINRSEKTEITGAEKNKLFPSNLAMVVNDFLVEHFPNVTDYNFTAKVEQEFDEIAKGEKIWNNMIKKFYGEFHQKVDDAESIERKDVNTGRELGVDPKTGKKVIVRLGKYGPLVQLGETPDSEDENAEKPKFASLRKGQFIESITLDDAMELFKLPRELGDYEDQKMVAAIGRFGPYIRHDGKFVSIPKGEDPLDITADRAIELIEEKRKADREKFIKSFDEDPDVQVLNGRWGPYIKFGKKNVKIPKDKEPAELTYQECVELAEKTPDKKGGRKAAPKKKATKKK
>NC_014759.1|WP_013455664.1|4200350_4200632_-|N-acetyltransferase
MKIEIKEKQHTGKLFVGDENDPKAEMKFTKESGNILNVKHTEVSEELKGQSVGRKLLDHLAEKARNENFKLKADCSYVQHVFNKYDDYKDVQL
>NC_014759.1|WP_041650896.1|4200750_4201572_+|DMT-family-transporter
MIIAGFLFATMNVFVKMLPNIPAIEIVFFRSLISFVMSFVYLRAIRVPVMGNNKKLLVARGAVGAVALTMYFYTLQNIPLGSAVTMQFLSPIFTSILGVFIVKERVHPKQWIFYIMAFAGLIIIQGFDPRISIEMFAIGIGSSIMAGLAYNIIRKINKTEHPLVIVFYFPLVTTPLTGLYSAFNWTMPVGEEWLILLAIGVLTQFAQYFMTMSYQSEDLSKVASLKYLTIVYALAYGYVFFDETYNWIVFSGIALILAGVILNVWFKNKIGKA
>NC_014759.1|WP_013455666.1|4201741_4203274_+|PAS-domain-containing-protein
MNISKENISLEKENLQLKNELAGVKKKLAQYQYAAAGANEGLWDRNLITGEVFISPPWITMLGFQKDDSIEKSQLWENLLHPEDKENAVNSLEEFISGKRQEYNIQFRLKHQKGHYIWVQSTAQLTLDKDGQPIRVSGSHRDITEKKRSEEIIKTSEQKYKHFFQNSLIGIMRVRKSDLEVTEINQKGLNILALSEKKRHMKMTDPFKDKEDVNKFLEQLTDRESIEEFEAKFERWDESETWVSISALEIESEETAYYDIIFRDISEFKENLVELQRLNFELDNFVYHASHDIRSPLRSLMGLIDILKTETRTGEIRKIIEMITGSINRLDKFVVDLLAMSRDNRLEEPDTVPINFMVEVNNSITNFHHVYTTKNLEIRTKIIQWYPFYSDLTKIRIILNNLISNSIKYRKVLENEKEFSYINITIETSEKEAEIIIEDNGEGIPKDKLQKIFDMFYRASENSEGSGLGMYIVKNVIKKLNAKIDVDSKEGVGTKFTIKVPNSFKLENSK
>NC_014759.1|WP_013455667.1|4203282_4204101_+|3-methyl-2-oxobutanoate-hydroxymethyltransferase
MSVHKKPIKKITTHQLQEMKNRGEKISMLTAYDFSMAKLVDASGVDVILVGDSASNVMAGHETTLPITLDQMIYHASAVVRAVERALVVVDIPFGSYQGNSSEALRSSIRIMKESGGHAVKMEGGAEIQESIKRILSAGIPVMGHLGLTPQSIYKFGTYTVRAKEEEEAEKLIADAKILEECGCFSIVLEKIPAELAKRVAKEVNIPIIGIGAGPYVDGQVLVLHDVLGITTEFKPRFLRHYARLDTVITEAIGKYVEDVKNIEFPNEDEMY
>NC_014759.1|WP_013455668.1|4204701_4206933_+|NADP-dependent-isocitrate-dehydrogenase
MSKTAKILYTKTDEAPALATYSFLPIIKAFTDSAGVVVETRDISLAGRIISQFPERLKPEQQINDDLAELGEIAKTPEANIVKLPNISASIPQLKAAIRELQSLGYDLPDYPDEPENDDEKKVKAKYDNVKGSAVNPVLREGNSDRRAPKAVKEFAQKHPHSMGEWSKDSKSHVASMSEGDFYGSEKSLTLPSATEVKIELKTKSGDVKELKSGLKLQEGEIIDAAVMSASALRAFLKEQKEEAKKAGVLFSIHMKATMMKVSDPIIFGHAVKAFFEPVFEKHQATLDDLGVDVNNGFASLLSQIEELPEDKRSEIEADIEACYNDGPDLAMVNSDKGITNLHVPSDVIIDASMPAMIRTSGQMWNKDNKTQDTKAIIPDRSYAGVYQETIDFCKKNGALNPATMGSVSNVGLMAQKAEEYGSHDKTFEIPEAGTVEVKDSNGNVLLSHEVAEGDIWRMCQVKDAPIRDWVKLGVNRAKDTGNPAVFWLDSNRSHDSELIKKVNEYLKDHDTNGLDIRIMNPVEATRFSFERIVEGKDTISVTGNVLRDYLTDLFPILEVGTSAKMLSIVPLMNGGGLFETGAGGSAPKHVQQFMEEGHLRWDSLGEFLALAVSLDHLGKTFNNEKAKILGAALDNATSKFLDENKSPSRKVNEIDNRGSHFYLAMYWAEALANQDEDADLKKIFSRVAESMSLKEAIINEELIAAQGKAVDMGGYYKPEESVLIKQMRPSETLNQILESIVN
>NC_014759.1|WP_013455669.1|4207127_4208891_+|DUF1800-domain-containing-protein
MPLTPLNESLGRQRASHLLRRTTFGATPNLVEEFAQLNPQQAIERLFINGIPFPQPPIDPATGQEWMSTGTIDANSEGFELEQYFLSWQIGQFLGPNATDDQKLSYIFRERLVYFLHTHFTTKKSIVGSSRALYFQNQLFRQFAFDQFIEVEETEEQLNFKDLVVKISLDNAMLRFLDGRLNVKGSPNENYARELLELYSIGRGLEGTDKGDNEVGDYGTFTEQDVQEGAKILSGFNVDADFANIDEQTGLPTGIAKGNGITAGQHDNTSKQLSFRFSNAVISPDPELMLNGQATYESAVDEIRQLIDAIFEQEETAIHICRKIYRFFVYHEITEDIQNGVIKDMASVFREQNFSLQAVLEALFASQEFYEGADGISDDNFGSIIKSPLDLIIGHARSVELQLPDYLTQAEQFYEITDGWLRKMGDMGLNFYEPFEVAGYLAYHQFPIYHRGWITTSYLTQRYAYVQSVSNANMEEMAVQMKTPIEYVEQYVDNNVAANAKDLVVVIANQFLAFTDNLGFENPDNSPLTEERLNYFLDAFLKTFQIDENPEEAWTFRWTQGVDRETVERQLQDLFNAILQSPEYQLM
>NC_014759.1|WP_013455670.1|4208893_4210594_+|DUF1501-domain-containing-protein
MDRRKFLKRLGFAAGGSIAFQGIPMRLLSSHQPLKNLLHKSDNEKVLVILQLHGGNDSINSFIPIENYDLYYNRRANIAIPYKSGNRTLIPLDSTLEAPDQVGLHPDMIDFKSMYDRGQAAVYQGVSYPKNNGSHFRGRDIWFMGGDYDDYYSSGWIGRYLNQVYAPADYPDDFPNAGMPDPLALEMGNDTSLLFHQEGNIPTSISLGNSPGALLNQIENLEGFADQGIDPRGLPPEHLNGSPYKKEMDWILGLEDKSETYIKRLQEIYLASNESSVEYPEIYPFNAPSGSLRNPLSGQLKLVSRLLGGGIKTKVFLVKMGGFDTHAGQVESTNTTMGVHATKMYHISAAMKAFHADLKARGLEDKVLTISMSEFGRRIPSNGSYGTDHGKGGAVMVFGNRVNPGVFGTNPDLNKSNIDLQFDYRQLYGSILHEWLGVDKASINNDIFFKDFFNASDENGNPLPDVQMISNSITGTNAWLGKHFNVDNPFPNPAGDFTNIRIQSNEEDKVRIEIITINGQSIGVEHKLLRQGSNDIKLDIAGLKSGIYQIRVNTKYINDTKKLIKK