CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_014931	Variovorax paradoxus EPS, complete sequence	2 crisprs	RT,Cas9_archaeal,WYL,csa3,DinG,DEDDh,cas3	0	0	4	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_014931_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014931_1

609111-609224

Orphan

Consensus_repeat	Method
GCCCTGAGCTTGTCGAAGGGCTGGGCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014931_1

>merge|NC_014931|1|609111-609224|CRISPRCasFinder
GCCCTGAGCTTGTCGAAGGGCTGGGCACCGCGCGCAAGGTTTCGAAAAGCTCAGCCCGAACGGCTGTTGCAGTTTTCCACCCCGGTGGCCCTGAGCTTGTCGAAGGGCTGGGCA

>NC_014931|1|1|609111-609224|CRISPRCasFinder
GCCCTGAGCTTGTCGAAGGGCTGGGCA	CCGCGCGCAAGGTTTCGAAAAGCTCAGCCCGAACGGCTGTTGCAGTTTTCCACCCCGGTG
GCCCTGAGCTTGTCGAAGGGCTGGGCA

Protein	Signature genes	Signature genes Name	Protein_function
NC_014931.1\|WP_013539015.1\|603417_605310_-\|hybrid-sensor-histidine-kinase/response-regulator	unknown	unknown	gnl\|CDD\|223715
NC_014931.1\|WP_013539023.1\|615745_617689_+\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_014931.1\|WP_013539018.1\|607751_609083_+\|type-VI-secretion-system-baseplate-subunit-TssK	unknown	unknown	gnl\|CDD\|377569
NC_014931.1\|WP_144299075.1\|621456_623403_+\|caspase-family-protein	unknown	unknown	gnl\|CDD\|334197
NC_014931.1\|WP_013539019.1\|609311_610676_+\|DotU-family-type-VI-secretion-system-protein	unknown	unknown	gnl\|CDD\|180801
NC_014931.1\|WP_013539029.1\|624021_624876_+\|virulence-protein-SciE-type	unknown	unknown	gnl\|CDD\|226862
NC_014931.1\|WP_013539017.1\|606582_607608_+\|phosphate/phosphite/phosphonate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270293
NC_014931.1\|WP_013539020.1\|610672_614272_+\|type-VI-secretion-system-membrane-subunit-TssM	unknown	unknown	gnl\|CDD\|274531
NC_014931.1\|WP_144298940.1\|614274_614913_+\|type-VI-secretion-system-associated-protein-TagF	unknown	unknown	gnl\|CDD\|370730
NC_014931.1\|WP_013539024.1\|617749_619342_+\|murein-transglycosylase-A	unknown	unknown	gnl\|CDD\|377065
NC_014931.1\|WP_013539028.1\|623462_624020_+\|hypothetical-protein	unknown	unknown	unknown
NC_014931.1\|WP_041943216.1\|600234_602139_-\|response-regulator	unknown	unknown	gnl\|CDD\|223715
NC_014931.1\|WP_013539012.1\|599086_600073_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|181818
NC_014931.1\|WP_013539016.1\|605456_606515_+\|phosphate/phosphite/phosphonate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270293
NC_014931.1\|WP_013539010.1\|597446_598232_-\|hypothetical-protein	unknown	unknown	unknown
NC_014931.1\|WP_041943218.1\|602186_603152_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380548
NC_014931.1\|WP_013539011.1\|598342_598975_-\|cysteine-hydrolase	unknown	unknown	gnl\|CDD\|238496
NC_014931.1\|WP_013539026.1\|620149_621304_+\|hypothetical-protein	unknown	unknown	unknown
NC_014931.1\|WP_041943214.1\|596571_597441_-\|FkbM-family-methyltransferase	unknown	unknown	gnl\|CDD\|377448
NC_014931.1\|WP_013539025.1\|619371_620121_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_014931.1\|WP_013539015.1\|603417_605310_-\|hybrid-sensor-histidine-kinase/response-regulator	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	8.0208e-46
NC_014931.1\|WP_013539023.1\|615745_617689_+\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.40453e-55
NC_014931.1\|WP_013539018.1\|607751_609083_+\|type-VI-secretion-system-baseplate-subunit-TssK	gnl\|CDD\|377569	pfam05936, T6SS_VasE, Bacterial Type VI secretion, VC_A0110, EvfL, ImpJ, VasE. T6SS_VasE is a family of of bacterial proteins that are essential for the type VI pathogenic secretion system, although the exact function of this particular component of the system is still not known.	1.03528e-174
NC_014931.1\|WP_144299075.1\|621456_623403_+\|caspase-family-protein	gnl\|CDD\|334197	pfam00656, Peptidase_C14, Caspase domain.	3.67839e-07
NC_014931.1\|WP_013539019.1\|609311_610676_+\|DotU-family-type-VI-secretion-system-protein	gnl\|CDD\|180801	PRK07033, PRK07033, DotU family type VI secretion system protein.	5.05563e-170
NC_014931.1\|WP_013539029.1\|624021_624876_+\|virulence-protein-SciE-type	gnl\|CDD\|226862	COG4455, ImpE, Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only].	5.1521e-76
NC_014931.1\|WP_013539017.1\|606582_607608_+\|phosphate/phosphite/phosphonate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270293	cd13575, PBP2_PnhD, Substrate binding domain of ABC-type phosphonate uptake system; contains the type 2 periplasmic binding fold. This subfamily includes the Escherichia coli PhnD (EcPhnD) which exhibits high affinity for the environmentally abundant 2-aminoethylphosphonate (2-AEP), a precursor in the biosynthesis of phosphonolipids, phosphonoproteins, and phosphonoglycans. The Escherichia coli phn operon encodes 14 genes involved in binding, uptake and metabolism of phosphonate, and is activated under phophophate-limiting conditions. PhnD belongs to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. The PBP2 have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. PhnD is the periplasmic binding component of an ABC-type phosphonate uptake system (PhnCDE) that recognizes and binds phosphonate.	4.01998e-58
NC_014931.1\|WP_013539020.1\|610672_614272_+\|type-VI-secretion-system-membrane-subunit-TssM	gnl\|CDD\|274531	TIGR03348, VI_IcmF, type VI secretion protein IcmF. Members of this protein family are IcmF homologs and tend to be associated with type VI secretion systems. [Cellular processes, Pathogenesis].	0
NC_014931.1\|WP_144298940.1\|614274_614913_+\|type-VI-secretion-system-associated-protein-TagF	gnl\|CDD\|370730	pfam09867, DUF2094, Uncharacterized protein conserved in bacteria (DUF2094). This domain, found in various hypothetical prokaryotic proteins, has no known function.	1.94072e-40
NC_014931.1\|WP_013539024.1\|617749_619342_+\|murein-transglycosylase-A	gnl\|CDD\|377065	pfam03562, MltA, MltA specific insert domain. This beta barrel domain is found inserted in the MltA a murein degrading transglycosylase enzyme. This domain may be involved in peptidoglycan binding.	4.79241e-57
NC_014931.1\|WP_041943216.1\|600234_602139_-\|response-regulator	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.98429e-45
NC_014931.1\|WP_013539012.1\|599086_600073_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|181818	PRK09393, ftrA, transcriptional activator FtrA; Provisional.	1.84249e-130
NC_014931.1\|WP_013539016.1\|605456_606515_+\|phosphate/phosphite/phosphonate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270293	cd13575, PBP2_PnhD, Substrate binding domain of ABC-type phosphonate uptake system; contains the type 2 periplasmic binding fold. This subfamily includes the Escherichia coli PhnD (EcPhnD) which exhibits high affinity for the environmentally abundant 2-aminoethylphosphonate (2-AEP), a precursor in the biosynthesis of phosphonolipids, phosphonoproteins, and phosphonoglycans. The Escherichia coli phn operon encodes 14 genes involved in binding, uptake and metabolism of phosphonate, and is activated under phophophate-limiting conditions. PhnD belongs to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. The PBP2 have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. PhnD is the periplasmic binding component of an ABC-type phosphonate uptake system (PhnCDE) that recognizes and binds phosphonate.	2.43867e-59
NC_014931.1\|WP_041943218.1\|602186_603152_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|380548	cd06325, PBP1_ABC_unchar_transporter, type 1 periplasmic ligand-binding domain of uncharacterized ABC-type transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This group includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); its ligand specificity has not been determined experimentally.	1.17713e-11
NC_014931.1\|WP_013539011.1\|598342_598975_-\|cysteine-hydrolase	gnl\|CDD\|238496	cd01014, nicotinamidase_related, Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia.	8.95082e-44
NC_014931.1\|WP_041943214.1\|596571_597441_-\|FkbM-family-methyltransferase	gnl\|CDD\|377448	pfam05050, Methyltransf_21, Methyltransferase FkbM domain. This family has members from bacteria to human, and appears to be a methyltransferase.	1.87728e-25

>NC_014931.1|WP_013539018.1|607751_609083_+|type-VI-secretion-system-baseplate-subunit-TssK
MSWRTKVVWSEGMLLQPQHLQQSERHADHARHVLLRSTTPYAWGFAELEIDQAALTLGKLALVRAVGIFGDGTVFDMPAVDPLPEPIDIPSSMRDEAVVLALPLRRAGAREADAEEYEELVRHRVLESDVPDSNTAGERTAMLQLGQLHTRLMRASEATDAWTTMGVARVVERRTDNQVQLDRGMLPPLLDVAGHAVIRAWLDELLGLLRQRGEALAGRMTQGGTGGVAEIADFMLLQAVNRNEAIFAHLAKSAMLHPQHFFEHALGLAGDLSSFRDTRRVARFGPYIHDDLALSFRPVMDDLRRSLSMVFEQSAIRIELHDRKHGVRVAMVTDVELQRKATFVLAVNANMPSEALRARFPTQVKIGPVERIRDLVNLALPGVTLTPMPVAPRQIPFHTGANYFELETRNSDLWRQLEQSGGIAMHIAGDFPGLDLAFWAIRS
>NC_014931.1|WP_013539017.1|606582_607608_+|phosphate/phosphite/phosphonate-ABC-transporter-substrate-binding-protein
MPPALKHLLAAAFIAASGLLPPSLALAQAVNEKPVQTIRFGVLPLGGTVESRALWTPFMADMSRSLGIPVNAYSVPSYEELDRAIGKDEIDMAFLSAKMALDAVMQRRMKVVAQIARRPGMPEHRAVLLARKAGPLNTLEGMLAQPERWRLARGDSRSVTGFVVPQSQLFLPNNIEMETRFLSEFVGTHQATALAVANGDADVATNNTTDLERFRQQFPIEAERLQVIWESTPPPGAPMVVRRNYPPEFQAKLQNFLITYGQGKGPHADGEREVLKNLRAAYGYVAADDSALLPEARLEYELGKQRAMAAAWVNEAARAQRLQRIEKAYAEQVQTLRAGGR
>NC_014931.1|WP_013539016.1|605456_606515_+|phosphate/phosphite/phosphonate-ABC-transporter-substrate-binding-protein
MLAFLRHFAAVPAVFSAAFRAAALAFFVGLPVVAAAQTAQAAPPDKTAVRFGILPLGGAFESRSDWDPLLAELSRAIHRPVSVLSVNSYEALEQAIQRDEVDMAFLSGKMALDAVTQRRMKVVAQVVRHDGLPGYRALLLARKTPPLNTLKDLMDQPERWRLARGEKQSVSGFIVPQLQLFLPNHIVMETRFLSEVVGTHQTNALAVANSEADVATNNSADFERFKLRFPAEAQRLQVLWESELIPHAQIVVRREYPAELRSRVQAFLTAYGRGKGPRGDAERLVLKSLHDLAGFVVADNSSLQPAAKLAYQLAKQNAVTAQFVNDAAKQARLQRIENGYAEQVSVLRDIAP
>NC_014931.1|WP_013539015.1|603417_605310_-|hybrid-sensor-histidine-kinase/response-regulator
MNWNFRVLRGLARLTFAQQLILLALVPATAATLTAIAVLTRQHLGNLTELMRANAQTVALQVATVAQAPLARMDKRALQRTAQSGTYQPHVQQVQIWTEDGEIVANSETVDRARGEGLQVVVPIVADDGRHNGKVMVEISLSAVQNARRSVWLNVAVVLAISLLGVGLAGWWAARRISEPIRALGKAVDRLGAGEDASVAIEGTSEVKHLQLGFNHAARALAESRRLLQSRINEATAELARKNALLEVASQAKTRLLAAASHDLRQPLHALTLFSDGLANGETDPVKLQRIGHIRECVESLDRLFSELLNLSQLDAGVLQPQWADFPLDRLFDEISRNFRPVAEQQGLRLVARKTELWVRCDYVMLSRILNNLVSNSLRHTLEGGVLIGARRRGKGVRIDVVDTGVGIAAQHQTRVFEEFYQVEPAGRPSARGARGMGLGLATVQRLTELLNTRVELSSRLHKGTCVRVLVRSAPAALPSPTPSPVAAGMEDGEPSLANLRILVIDDERTILEGLSVVLANWGAEVLVAQTRAEALALADTWAEPPDVVVSDLLLQGGDNGLDVIAALERHPRGIGPGTARLLVTGETKPDRLREVASAGIAVLYKPVSPRVLRQSIHAQRAAALLNLDA
>NC_014931.1|WP_041943218.1|602186_603152_-|ABC-transporter-substrate-binding-protein
MSMASRAAAAPSLTVLMSDDNPAHSEFVQQLRAGQEPGGRFELVRLSPTGEMPQGVETASAETEPRANAGVRTRSMRPSAADANLTMAVGAAAARAAVERPGQEPLVLAMLSRLDYEALKAASPALKRGDRRVGVLLRDPAMADQLALIHAVLPQKHRIGVVATPESEPLVRELQRAAQGANPAWEVRVEYAPDARSLAAALRTVVPMSDALMVLPDLIGDNQAATLSVLRAGASAGLAVFGASEGLVRSGGLAAAVSTPSQLAQQARLLGQKVAVAGSSNSPLVEAATPATVRVNATVARGLGLRLPEERELTDRLAAPR
>NC_014931.1|WP_041943216.1|600234_602139_-|response-regulator
MQPRAASALVVRGNLQGDLFRLGVVPCAAVALALTGWFTHNRLQTLEAQFDAEGEAVARQVAAMSDLSLYAGDVPALQNVANAALRGGQVMRVEISNSAGVYVTAGPKNESLAQLRMFTSPVTLREASRASAFAPAGSTAAGDTPIGLVQTFRDTTAYARERSRSLMAGIGIALVALLAAWASVRHMARTVARPLRRVSRTVAALEAGHFDMRCEVVEGGTRGSHELAVLAHDIDRLAERLQHNRQVSEERVREATAVALQRMAEAEQAALSRARFLAAASHDLRQPLHAMGLFIDGLLPTASAAQRPAVLRLQESTEFMGVLLDDLLEISRLDAQVLTPTITRISLAALFDQLDAQHAAAAIEARVRLRWSDRGLAVRTDAAMLQRIVNNLVANALRHAPEGGTVLVAARRIASGVRIEVRDNGVGIAPIHQGRIFEEFYQVANTERDRRRGFGLGLAICARIATLLGTRITVRSALQAGSTFAFTLPAARAADVVLPEPAPVAPAPLAGLRCLVVDDDPAILDGSRALLEQWGCEVECVATGAEAIARMGTGDIHFDAVLCDLQLAGDGDGVDVIEAAKRLQPDALAVLVSGATGPEVLQRLRHGGVMLLTKPVPPAKLRALLTTRRHAHAA
>NC_014931.1|WP_013539012.1|599086_600073_+|helix-turn-helix-domain-containing-protein
MARTTTTTTETIAVVAFDGISPFHLSVPCMVFGEDRTEAGAPRFRMRVCAPEPGPLRTNAGFDLVVPHGLEAIRRAQIVVVPSWRDDGRPAPPALIRALQAAHRRGATVVGLCLGAFVLAEAGLLDGRPATTHWNLAAAFAKQYPKVSLQPEVLYVDDGDVLTSAGTAAGIDCCLHLLRVRYGAETANRAARRMVVAPHRQGGQAQYIQQPMPATAERDRLAPLLEWLGKHLDVPHELDELARRALMSRRTFTRRFRESTGTTVGQWIQNQRLALAQRLLETTDHPVERVATGAGFGSAVSLRKHFTSAFKVSPTVYRRQFSRTEEAA
>NC_014931.1|WP_013539011.1|598342_598975_-|cysteine-hydrolase
MSNTAAPRRVLVVIDVQNEYFEGGGLPIEYPPILDTLPNVTKAMDAAHAAGVPVVVVRHHAPKGAPVFQADTHNGQLHPEVANRPRDHLITKTFPSVFTGTDFADWLALHEIDTLSVAGYMTQNCDASTVFEAMHRGLNVEFLADASGALPYANDAGKVTAEEIHRVFSVVFHSNFAAVTSTAAWITAMQEGQAIAKDNVVMSNRRARGV
>NC_014931.1|WP_013539010.1|597446_598232_-|hypothetical-protein
MPDLSALKDIRPFVATPSYGGTMTSLYVRSLLGLVNLAWEHRFPMQTRFLDGDSLITRARNRLVAEFMADTRWTHLFWIDADIGFEPEAALRLLCAGRDVVAGIYPHKTDGWPAGGLREPLPAGATREDFEALHASFPANAFDTRLSVDAEGFTEVLDAPTGFMLIARSVFERLAAAYPQLRYTPERAADPATRDLPHYRFFDVLAEPDNGAYLAEDFAFCRRWQSIGGQVFIDARSNLSHQGTRTYTGHFGRALAVREGR
>NC_014931.1|WP_041943214.1|596571_597441_-|FkbM-family-methyltransferase
MTQTTRAAVDLRDILAPRRLTEVVDVGANPIDGDPPYLAMLQAGLCRVTGFEPQLSALHELTQAQGPLERYLPWALGDGGMHTLHVCAAPGMTSLLAPDAQSLALFEALQPLAEVRERIAVQTRRLDDIAEIAHLDFLKIDVQGSELAVFRAGRAKLAQAVMVQTEVSFVTLYKDQPTQGEIDQELRGQGFVPHCFAAVKQWPIAPCVVDGDPRRPLRQLLEADLVYMRDIRRPEAMDDEQLRHLALVAHHCHGSFDLALRCLLLLEERRAVEAGAQQRYLQLLAARGA
>NC_014931.1|WP_013539019.1|609311_610676_+|DotU-family-type-VI-secretion-system-protein
MSTPPDPFAAFESERTVIKPKPRTPAGTPPAATPAPFFGGADPTPAVEVGEIGLLNPLVSAAGKLLVLIGKLRNLAQPPNVPALRASTADAVNQFDASARRSGVSNESVLAARYVLCTALDEAVANTPWGVQAGWNKQSLLVQFHNETWGGEKVFQLLAKLAQDVPTHRQLLELIYSVLALGFEGRYRVVDNGRAQLDSVRQRLADLIAKDRPAVEPELSPHWRGQGAGTVRLRESLPLWVFAAGFAFLLALAWVGMQIMLNQRSDTTYAAVSGLRVPNIQIAPPAPPAKTPRLARFLEPEVKQGLVTVTDEADRSVVRLRGDSFFGSGSAEPMAASLPVLRRIGQALAEVKGDVLITGHSDNQPIRSLRYPSNWHLSAARADAVKGALTTLVDPARMRSDGKADAEPVAANDTPANRARNRRVDIVLLTEPERIASAAPVAPAPAAPVPGATK
>NC_014931.1|WP_013539020.1|610672_614272_+|type-VI-secretion-system-membrane-subunit-TssM
MIKKIFGFLFSPLLLTLLALIVVGLLIWWIGPLVKIGSLAPLESELARWLLIGAIVLIVVLRMAWRRWRARRASQHLTDGLMKAPTVKTDAPANGEQKILDTRFSEAVATLKQMRLHAAGKKPGWRDWMSISGGSYLYDLPWYVFIGAPGAGKTTALVNSGLSFPLAEKFGPGAIRGVGGTRNCDWWFTDEAVLIDTAGRYTTQDSHQTEDKNAWEGFLGLLKKARPRRPLNGVFLTVSVADLLSQGPEQRTQLAASIRARLLELDSKLTTRLPVYVLVTKSDLLYGFTDYFDDLGKEQRAQVFGFTLPADENVQTEEKGLSTAFHREFALLHNRVNDGLIPRMQRETDGGRRAAIFGFPAQFGSIGSLLSDLLDQVFTGSRFAQPPWVRGVYFTSGTQEGSPIDRVMGSLSRSFGIERAMLAPQKSSGRSYFLTSLLRDVVFPEQRLAGADVKLERRRHLLRMTGVAAMTLVTVGLIAGWGYSTWQNTNYLKSVEARAVPAQKSLANLPVQLQNLVEVAPVMQGIRDIWKTPENRQGDEPLSMTLGLYQGNKLDAAARLAHQRALNDVFLPQIAKRIEDQLRTAQKDNLEYTYEALKSYLMLYQPEHFDPEALKAWITLDWARSLDRGIPEEQRMALEEQLDVLIAQGPPRSPLKMDENLVRSVRAVLASYPLEQRVFSRLKRQRATKDIPGFSVATAAGPSAPLVFERISGKPLTEGVPGMFTYDGYHKRFQNEVTVLTGLLAAEDPWVLGQDKGAADRLRDVAALGALTDRVRRLYLAEYVKQWEALLGDVRLIRATGLDKNIEAARILSGVSSPLANFLRAVVKETTLIPADQPKDVVSKATATVASTRKGLEDLFGGDPNKPVATGKRIESIVDDRFEPLRRLVTAAAPGQPAPIDDALKLFNEVYVYLNAVDTAVKGRTSPPPGDVAGKLKADAGRLPEPVRSMVENLSQSGAAQAQVAERGNLSQDLRPVTEFCARAIAGRYPFSPTSKRDVLPEDFGQMFGAGGLMDDFFQKRLAALVDTSTRPWRYKPVAERGAITTQALAQFERAARIKDIFFRAGGRGPSMRLDFKPVEMDAGITQFILDVDGQLVKYAHGPVVPMAVQWPGPKGSNQVRIQVSPPSTTGSSGSAVDGPWALFRALDDGQLEAGDAPEKFFITFQIGARKTRFEVTTNSVQHPIRLRELREFSCPEGL
>NC_014931.1|WP_144298940.1|614274_614913_+|type-VI-secretion-system-associated-protein-TagF
MATSSSSSSSLFTSTELPGWFGKLPGMGDFAHRRLPESFRTVWDQWLQRGLARLRDRHADWTAHYLEAPIWCFALGPQVAGERGWIGVLMPSVDGVGRYFPFTLAVELAGDVSDALQGEALVAALQWWALATQAALEGLDGDLDALRFDAVLGRLFVAAAAGSVDGVELLEMPAAGASLWLGDPAVEGGVRMLATGLPRDAQFEALFLGGGE
>NC_014931.1|WP_013539023.1|615745_617689_+|protein-kinase
MTDSPSNSSPPEDDRTRVVSRPAPQQQTTGTGDTAATVISAGVTSLSNVPVTSPASATHEAGLLPVGSRLAEFEITRVIGQGGFGVVYEAWDHDLERVVAIKEYLPTSLSTRQNDGTVVPLSERHRETFDLGMRSFINEARLLAQFDHPSLLKVYRFWQERGTTYMVMPFYRGDTLREALVAIPAGVDESWLIRIMDGVTQALGVMHNANCYHRDIAPDNIILLEGSGRPVVLDFGAARRVITDKTQAITVILKPGYAPIEQYAEMPDMSQGAWTDVYALAAVMHVAVCGRAPPPSVARLLSDSYVPLAGNDILRQRYSLKLLQAIDAGLGVRPEQRPQSMADLRAALDLEVGHSIAPTPRTQPPSGARTGGGNNNTGSNANAATVIAGKKAPPPPAPAPGSGNSGAGKGKAVAAIASIAVVAAVAGGGWWWYQGRAGGTDKQDVAIATPPPPLENVTKLDPPPPPPPPPPPPPPAAPRTPLESLQSLAAGAAPGFEVTATAKKPEVAIGKDKLAFEVRSKRDGFVYVFLLSSGGEMFLLFPNLLDKYNKINANSALALPRASWPMDAGGPAGTNQFAVLVSEHERDFSASGVQNDGVFPQFPLPVLSALEATRGTGPSPLLGKPTCAPGAPCNDVYGVANFKIVEK
>NC_014931.1|WP_013539024.1|617749_619342_+|murein-transglycosylase-A
MHTSSQSPRFTGSTLIRWAAFAAVASLAGCVNPPPAATTADTTAATDTSSTTSSRPASTGASVAGQARTFSTQLATYTAVSFDAMPGWSRDDFSETWPAFLGSCKVLTGRGAEWKEVCDRAGKVDGKNRNAIRGFFESEFSAYQIRDDDRKPDGVVTGYFEPEIAGSRTYGAPFIYPVYGQPEDMLFADARKLPAGSGTVAAKVEGRNVVVQTGLSTRDMGAPGLYALDLSAITRDTLDRKVRMRIEGKQLLPYYTREEIETKGAPNAKVLAFVSSATALYEMQIQGSGRIKLANGDTIRVAYAEQNGQPFRPTIAQAANGKPRSAVKVRGSSIELQLDDGDDDDVGSVDSSVIRTRGFTLARPTASGAVVVPGRRTAGAVAGSGIKDPSYVFFKEATSPAGGPVGAFGVPLSAGRSIAVDPRSTPLGYPVFVSTRTPGSGAPMQRLTIAQDTGGAIRGAVRADYFFGNGQAAATNARRMKERGQLWILLPRGLAVAQAAVSSAIRTRGAAVGAGLPQCLVPTEGQCVDD
>NC_014931.1|WP_013539025.1|619371_620121_+|hypothetical-protein
MQETLSSAESTELVRLWRRRQTLSSNDMGTMYRIVGDALVACNPPELQILGEGRQELVAQFIYVKVLRLDADPDEADERASHSAPSTAFALCAYFRRYLIDCTRASSFRRKLSIGDQITEAQLEDEIGAGDDLEGCLAEHGLSAQAVQLAARAFIAELPEPERILLCEGFGKEAEGGLSGIASRHAIASYHYRAGRLGLVHKREGLTADYAKTRLGGWIQQTLGIAIEAENMAAILQVFKILGAEASYA
>NC_014931.1|WP_013539026.1|620149_621304_+|hypothetical-protein
MNTELWPPLSVIRNAFETGHAAVPDAAAAGVATVAMPGTTSQATPQAAPAAAPVLQDLLLPLTELARRREAVAQRGFTARWAPGRLLSVLHEGRLLGVLLDRCIHGDLWQGWMAAGEADWASAFDVLLEPDDEPFEPAFGLIQAWNVLTLEPSPQLCARVLGEVSATRLAAIRAVHDEWAAQKVLPIAPEPGHIALRTVGGVFSVLSGTPLGARDPRADYQALYRTVGLQLGSALTPSAKAAPAAPVPPRARPQERPEGGWWGSIRRWFGADGWMRPAFAVLALCVVVQNVGLLGGRGSEEDEVRFRNVPTAPAAASANLVVRWKDGVRVDEADRLLRTMSAEVVGGPGTNGVWRLRVDDPVGGLSMLAASPLVESAGPASERP
>NC_014931.1|WP_144299075.1|621456_623403_+|caspase-family-protein
MSLALLVSGSTAFATQRALLVGVSELVNQPQALWLQAPRNDVMLMRDALLKQGFAPADITVLADGVSGSVLPESQAIHEALGRLLAQSKSGDFVLLYFSGHGTRLRDSNKRYQEPDGLSENFLARDVRGTLGADSALTGDLRDADFDAWIQAFLARNVFVASVFDTCSANSMTRSTTDAPAIADGPPGDEVRWRGLRTAQLVGAPGPAARVAMTRPTVTDPVPRARYVALFASESHQITPELRLPRKNRNARPQGLLTWAVVEALSRKPATWRDLFDGVLAVYPPVIDELAQRFPTRELPSPVAEGNLDAPIFANRAQAVTTRPVWRAQRSGDTLTLQAGQLDGLVVQQPLRVLATMDDGTVRSAEGTLAQAFNDKARMAVPAALRELSGAALWNITPLGEPATVALRVRAEQGLPPGLSLEYPASVIAVNETDGADARWSAGRLEVLSPMLGAGAKSAPADAAVARRRLEVLARLKWLNQLYTIARDAQFDGFDAVFEIWNGDRLVRSGSAQQVDAKLLPLRSGERAVLNVRNTSARSVDLVIVGIDPQGAARQVYPEDPGETNRFKRGTREAPAVKRFELPWFNAEGGRLLVLATPAAPYSAPRLFGTGAGDAVAEVRVRGALQPESERQTFAAMVHWAGEVSAAK
>NC_014931.1|WP_013539028.1|623462_624020_+|hypothetical-protein
MSWTYDGKLDPDEALRLLDYLSGESGNDFSMMIESKGTPIEGESVRTYEDGKQRMDIGGYSYKSDVVIPPGSSKGKLRNYSFIVIRDCDAATASIASLMKSQDADLKVTVSVFKAGGDSSKDLQSHLEFVLEGARVNCHAIVTGGTPKRPCDIIFFDYTKLEIRSAPQQKTGARGAVRTCTFTGN
>NC_014931.1|WP_013539029.1|624021_624876_+|virulence-protein-SciE-type
MATSSAELIKSADPVAALKALSDEVRAKPSDSKHRVFMAQLLCVLGQWERALNQLTVAAELDALAVPMKQVYGDAVRCEGLRAEVFAGTRTPMIFGQPDEWLALLIESLLRQGRGESELAEDLRQRAFDGAPAIAGTIDGTPFEWLADADMRLGPVLEAFVNGKYYWIPYARLAHIKIEPPEDLRDCVWMPAHLQFENGGETLALIPTRYEGSEKSEDGELQLARKTEWRELRPEVWAGTGQRVLGSDAGEYALMDVREILFNPVASAEAEAAPSQEGTESAGG

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Crispr_ID: NC_014931_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014931_2

4445180-4445275

Orphan

Consensus_repeat	Method
TTTGATCGACTTGTCGTAGTCACACTACGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014931_2

>merge|NC_014931|2|4445180-4445275|CRISPRCasFinder
TTTGATCGACTTGTCGTAGTCACACTACGATTATTCAGATAATTTCAAATCGCCGCAAGATTTTGATTTGATCGACTTGTCGTAGTCTCACTACGA

>NC_014931|2|2|4445180-4445275|CRISPRCasFinder
TTTGATCGACTTGTCGTAGTCACACTACGA	TTATTCAGATAATTTCAAATCGCCGCAAGATTTTGA
TTTGATCGACTTGTCGTAGTCTCACTACGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_014931.1\|WP_013542492.1\|4435932_4436478_+\|peroxidase-related-enzyme	unknown	unknown	gnl\|CDD\|130981
NC_014931.1\|WP_013542496.1\|4438669_4439446_+\|DUF1275-domain-containing-protein	unknown	unknown	gnl\|CDD\|377734
NC_014931.1\|WP_013542503.1\|4445406_4445796_+\|DUF2946-family-protein	unknown	unknown	unknown
NC_014931.1\|WP_049794541.1\|4449855_4450833_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NC_014931.1\|WP_041942974.1\|4443535_4444468_-\|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein	unknown	unknown	gnl\|CDD\|378065
NC_014931.1\|WP_013542498.1\|4440119_4441121_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270234
NC_014931.1\|WP_013542509.1\|4453685_4455080_-\|hypothetical-protein	unknown	unknown	unknown
NC_014931.1\|WP_013542493.1\|4436542_4437112_+\|redoxin-family-protein	unknown	unknown	gnl\|CDD\|239310
NC_014931.1\|WP_013542497.1\|4439478_4440027_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NC_014931.1\|WP_013542504.1\|4445897_4448102_+\|TonB-dependent-siderophore-receptor	unknown	unknown	gnl\|CDD\|273805
NC_014931.1\|WP_013542511.1\|4456678_4456978_-\|hypothetical-protein	unknown	unknown	unknown
NC_014931.1\|WP_041943891.1\|4441255_4442179_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270297
NC_014931.1\|WP_013542507.1\|4450829_4451672_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NC_014931.1\|WP_013542508.1\|4451668_4453078_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224048
NC_014931.1\|WP_013542500.1\|4442195_4443515_+\|sulfatase-like-hydrolase/transferase	unknown	unknown	gnl\|CDD\|293763
NC_014931.1\|WP_144299019.1\|4455634_4456561_+\|hypothetical-protein	unknown	unknown	unknown
NC_014931.1\|WP_013542494.1\|4437126_4437834_+\|MOSC-domain-containing-protein	unknown	unknown	gnl\|CDD\|225167
NC_014931.1\|WP_013542512.1\|4457734_4458367_+\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NC_014931.1\|WP_013542505.1\|4448266_4449829_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173855
NC_014931.1\|WP_013542495.1\|4437885_4438548_-\|suppressor-of-fused-domain-protein	unknown	unknown	gnl\|CDD\|377450

Protein	Function_ID	Function_description	E-value
NC_014931.1\|WP_013542492.1\|4435932_4436478_+\|peroxidase-related-enzyme	gnl\|CDD\|130981	TIGR01926, peroxid_rel, uncharacterized peroxidase-related enzyme. This protein family with length of about 200 amino acids. One member, from Myxococcus xanthus, is a selenoprotein, with an otherwise conserved Cys replaced by Sec. This family is drawn narrowly enough to suggest that These proteins contain a domain described by TIGR00778, with a CxxCxxxHxxxxxxxG motif. Some members of that family are known to act as peroxidases or correlate with resistance to oxidative stress.	6.63332e-22
NC_014931.1\|WP_013542496.1\|4438669_4439446_+\|DUF1275-domain-containing-protein	gnl\|CDD\|377734	pfam06912, DUF1275, Protein of unknown function (DUF1275). This family consists of several hypothetical bacterial proteins of around 200 residues in length. The function of this family is unknown although most members have 6 TM regions, and may be putative permeases.	6.00104e-37
NC_014931.1\|WP_049794541.1\|4449855_4450833_+\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	5.32002e-85
NC_014931.1\|WP_041942974.1\|4443535_4444468_-\|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein	gnl\|CDD\|378065	pfam08843, AbiEii, Nucleotidyl transferase AbiEii toxin, Type IV TA system. This family was recently identified as belonging to the nucleotidyltransferase superfamily. AbiEii is the cognate toxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.	3.39749e-28
NC_014931.1\|WP_013542498.1\|4440119_4441121_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	9.84783e-113
NC_014931.1\|WP_013542504.1\|4445897_4448102_+\|TonB-dependent-siderophore-receptor	gnl\|CDD\|273805	TIGR01783, Ferrienterobactin_receptor, TonB-dependent siderophore receptor. This subfamily model encompasses a wide variety of TonB-dependent outer membrane siderophore receptors. It has no overlap with TonB receptors known to transport other substances, but is likely incomplete due to lack of characterizations. It is likely that genuine siderophore receptors will be identified which score below the noise cutoff to this model at which point the model should be updated. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins].	4.37821e-101
NC_014931.1\|WP_013542497.1\|4439478_4440027_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	4.4475e-14
NC_014931.1\|WP_041943891.1\|4441255_4442179_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270297	cd13579, PBP2_Bug_NagM, Uncharacterized NagM-like protein of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	1.17048e-118
NC_014931.1\|WP_013542493.1\|4436542_4437112_+\|redoxin-family-protein	gnl\|CDD\|239310	cd03012, TlpA_like_DipZ_like, TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA family belong to this subfamily. TlpA is a disulfide reductase known to have a crucial role in the biogenesis of cytochrome aa3.	1.47506e-23
NC_014931.1\|WP_013542507.1\|4450829_4451672_+\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.00034e-56
NC_014931.1\|WP_013542508.1\|4451668_4453078_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224048	COG1123, COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only].	1.7821e-115
NC_014931.1\|WP_013542500.1\|4442195_4443515_+\|sulfatase-like-hydrolase/transferase	gnl\|CDD\|293763	cd16144, ARS_like, uncharacterized arylsulfatase subfamily. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.	1.29317e-125
NC_014931.1\|WP_013542512.1\|4457734_4458367_+\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	1.19265e-22
NC_014931.1\|WP_013542494.1\|4437126_4437834_+\|MOSC-domain-containing-protein	gnl\|CDD\|225167	COG2258, COG2258, Uncharacterized protein conserved in bacteria [Function unknown].	1.2778e-80
NC_014931.1\|WP_013542505.1\|4448266_4449829_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|173855	cd08490, PBP2_NikA_DppA_OppA_like_3, The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold. This CD represents the substrate-binding domain of an uncharacterized ATP-binding cassette (ABC) type nickel/dipeptide/oligopeptide-like transporter. The oligopeptide-binding protein OppA and the dipeptide-binding protein DppA show significant sequence similarity to NikA, the initial nickel receptor. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	1.00752e-160
NC_014931.1\|WP_013542495.1\|4437885_4438548_-\|suppressor-of-fused-domain-protein	gnl\|CDD\|377450	pfam05076, SUFU, Suppressor of fused protein (SUFU). SUFU, encoding the human orthologue of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signaling. SUFU exerts its repressor role by physically interacting with GLI proteins in both the cytoplasm and the nucleus. SUFU has been found to be a tumor-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signaling pathway. Genomic contextual analysis of bacterial SUFU versions revealed that they are immunity proteins against diverse nuclease toxins in polymorphic toxin systems.	1.90066e-22

>NC_014931.1|WP_041942974.1|4443535_4444468_-|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein
MNDLYLKTARLLTQVAPFVFADETFALKGGTAINLFVRDMPRLSVDLDLVLPDHTLSRDAALRKIKDSLGKAADALKAKGFRTHLSGVPAADETKLFVKRDDAEVKVEVNYVMRGTVKPVSVMGLAPRAQEVLQAELDIPVVSLDDVYGGKLVAAMDRQHPRDLFDVMQLLENEGITSGIRRAFVVYLASHKRPIHEVLFPRLRDVSTEFQANFQGMTTEPVELDALLAARDQMIATLHKELDAEERAFLVTLANAAPEWHRMGIAHLGAMPAIQWKLQNLAKLKELNPAKFEEQSRELAEKISGLGEAR
>NC_014931.1|WP_013542500.1|4442195_4443515_+|sulfatase-like-hydrolase/transferase
MTSRPNIIFIVADDLGYADLGCYGGRDAAFGPVSPVLDGLAANGLKLTQGYANSPVCSPTRFAMITARYQYRLRGAAEEPIRSSSRGSTTLGLPTDHPTLPSLLKASGYQTALIGKWHLGYPPHFGPLRSGYDEFFGPMSGGVDYFTHCDSAGQHDLWFGEEDKKEDGYLTDMLSKRAVDYVERMAKQEQPFFLSLHYTAPHWPWETRDDAEKAPAIKDNLFDLAGGNIHVYRRMIHHMDEGIGWIMAALQKHGMSDNTLVVFTSDNGGERFSDNWPLVGGKMDLTEGGIRVPWIAHWPAVIAKGGESAQLCMTMDWSATMLEAAGVKADANYPLDGVSLMPVLKDAKQSFRRPLHWRMNHRGQQAMRDGDWKYLKVDGNEYLFNIPADERERANLGKKEPERLAAMREDWLAWNATMPAIPEDATVSLGYSVKDMPQR
>NC_014931.1|WP_041943891.1|4441255_4442179_+|ABC-transporter-substrate-binding-protein
MATIAIGANAQTLDSPLHIVVGYAPGGATDRVARIVGEKLGAKLGVPVIVDNKPGAGGRLAAQQVKLTPAHQNVLMLANPAVMVVAPLVFKDNNYDAERDFVPVSYVNAYDFALAVSPTLPVRELPHLLAWMRANPQQANVGVPATGSLPHFFGLMVGEKARVQTQVIGYRGSAPLLNDLIGGQVPIAVDTEDVVIPQHNAGKLRILALSGEKRSPFAPNIPTFKEAGLDLAATGWNTFFAPATMPKDKVERLAATIRDVMQDPDTQRKFKDSGMTPVVSSQAQTIAMLKAYKTQWAPVVQKSGYQP
>NC_014931.1|WP_013542498.1|4440119_4441121_+|tripartite-tricarboxylate-transporter-substrate-binding-protein
MPSSSLAFDRRHALAALGGLALAPLADLAHAQPAFVPGQPIKVLIGVPAGGTQDVLTRAIAQQVRDSLGPLIIDNRSGAAGRIAVEAVKTAPPDGHTLLLGTASMMTMFPSAYRNLSYDPVKDFIPLLNAARFELALTVHKDVPANTLPEFITWAKAQGDKLSFGSYGAGTPSHFLGEMLNRAAGLKMVHVPYRGSTPARQDLMGGTVPVYFDTVGGAQQMLPSGRVKVLATSGEKRSPLMPNLPCFVEAGYKDVVATAWFAYYAPLKTPPAIVDKLRAELTRAVNTREVRQLLLQNGMYPIADGSDALLKTMREDTTRWAGIMKAVNFQAND
>NC_014931.1|WP_013542497.1|4439478_4440027_-|MarR-family-transcriptional-regulator
MPAAATVDAAAPRRPLDDLLLYRMSRLLSVAGSMVIRLCEGRFGITRREWRLIAVLASRGELSSSQLAEHAQLDRARTSKAVGSLVAKQLISRVAKAGDRRQVQLGLTEAGQSLYDALFPLVTKINGDLMKALDADDAARFDASLNLLQAKAERMVQEAVLPKADRGRRGASSSSPSSSRSP
>NC_014931.1|WP_013542496.1|4438669_4439446_+|DUF1275-domain-containing-protein
MRRLRFLTSRHRTPSTNRALGLLLAFNAGAVNAGGFLVLHMYTSHMTGFASQLADGLVLGNTRLLLNALGAVLAFLSGAAVCAVLVNWGRQQRLHSVYALPLLLEAALMLPFGLMGAVTLTWATPFAVPLTVLLLSFIMGLQNAVASKTSGGSIRTTHMTGNITDLGMEIGKLLYWNRKPDSTSTTTHAVRHDRSRMRRAAGLIAMFVLGGVVGALGFTHVGFVCVVPLAALLLALSVPPFMRDLPRSGLRVRFGKTP
>NC_014931.1|WP_013542495.1|4437885_4438548_-|suppressor-of-fused-domain-protein
MSSMEEVWAYREETLYPQLFGDKRSGIYVLDFDVFSSLGAEDIDPAWLHLGVFEFEPTPARNSWLYVTSGGSTPWETEPDEYDPEDYSWLGSELVIEVHSQPEDQWTIKLLRRVLAFNVLLAHGRFGEDKPLLDYGDRIPMGDVIRAKGSVGLRNIVLAEPKHYPATAQLASGKFDFLHVVGITDSEKDWAKAHSSEALVRLLEVHGGFPVTDPGRKAVA
>NC_014931.1|WP_013542494.1|4437126_4437834_+|MOSC-domain-containing-protein
MRLSACPIDALLVGAVAPLPDGRSPSGIRKSATDRALWLSPTGLQGDAQADLRVHGGPEKAVHHYPREHYAHWASRSGRADLLANAGAFGENVSTRGWDESNVCIGDVVRLGEALVQVSQGRQPCWKLDVHFSEPGTAREMQASGRTGWYYRTLEPGWVRSGAEATLVERPHPQWPLSRLIALLFSRDARFAPEWALAAELPALAERWRRTFGKRVASSSVEDWEPRLRTPPPEA
>NC_014931.1|WP_013542493.1|4436542_4437112_+|redoxin-family-protein
MFTTLAEAPALQVSRWLNTEVPLTLESLRGRVVVLHAFQMLCPACVSHALPQAKKTRQLFAASDVAVIGLHTVFEHHDVMTAAALDAFVHEYRYTFPIGIDTPSQGSIPATMREYQLQGTPSTVLIDRRGRIRLSHFGLLDDMALGGAIGQLAAEDAPTALAADPSNQAPSALQAAGRCDDDGCPTGAT
>NC_014931.1|WP_013542492.1|4435932_4436478_+|peroxidase-related-enzyme
MSRIELVSDTAATGEAKALLSQIHGAFGATPNMFRAVANSPAALKSMWGAFGALGGGVIPAQLGEQIAVAVADRNACHYCLAAHTALGRKAGASAADMAAAQAGESADPRTAAALRFALKLVDARGQVDAADVQALRAAGFDDAHIVEIVAHVALNLFTNYVNVALEVPVDFPGVKLRTAA
>NC_014931.1|WP_013542503.1|4445406_4445796_+|DUF2946-family-protein
MPLRPLPLQRLLRLLLLAVFFNAAIGMPLHEAGHMREAVESMAQAAGLDTIADDAASEADAPAHGDQENHRVCECCLAHVHFAAAPARLPAALEVVQTTALPRAPPGMAFEPFAGRWPFASRAPPNAST
>NC_014931.1|WP_013542504.1|4445897_4448102_+|TonB-dependent-siderophore-receptor
MTSFDLARANSRVFLFRRLPLALAASALFSGQAMAQSADAPPAPAALPAPSAAAQGQLTTVEVVGRTESGAYHADEAAGAKSDLPLRELPQSVRIVTRQAIDDLGATKLDDVLDYVGGVSRQNNFGGLWDNIAIRGLPGNENTGMATLFNGFSSNRGFNAPRDLAGVERIEFLKGTAAALYGSSEPGGTLNIVSKRPLWTSANAVEVYAGSQGLKRGALDLTGPIGGNFAYRLNVAAEDRDSFRDHVGARREVVAPAFTWKLGRDTVLEYSGEYLRHATPLDRGVVAVNNRLGAVPRSRFFGEPADGDVTVKNQTHQFILSHEWNSTWRSRVGLSYRETSLDGFSTEPTALLANGNLTRQRRYRDYSSKDIALQAELQGNVKTGGIEHELLFGVESFRFDMDTLMLRANPTAARPYAINIYNPVYGQRQPIPTANTDTLEHQKNTALYVQDAIRLSPEWRLVAGVRADNYSQSLLNRRNATTARQEPSSTSPRIGLSWLPTPQWTVYANAGRSFRPNTGSDVSANGFAPETGRSLELGTKWESADQRMGATAALFDIRKRNVLTSDPANAGYSVAAGEIRSRGLEFDFSGQISKHWRLTASLVLNDVEITQDNTLEAGGRLLNVPRVNGSVLAVYEDGLANGQRYGIGGGVTHVGRRLGEARTQAEAKAGKPAFDLPAYTTAKLVAYWRINPTLRLTLDVDNLFDKTYYASSYSRVWVTPGTPRTVTLGLQAKF
>NC_014931.1|WP_013542505.1|4448266_4449829_+|ABC-transporter-substrate-binding-protein
MTMPPDFTRRRALQFLAVGPAAAATTPLLAQPSATRAPLQIVGPWEIAGLSPASSGHVFTRMQITETLMNASDDGLPLPGLAERWRVSGDGLAWHFTLRAAARFHDGAAVTAAAVVRCLQAARVAPALLSQAPIRSVETEGVGMVVIRLTQPYGALPALLAHSSTMLLAPASYAADGAVRSIVGSGPYRVVSMAPPQHVEAAVFDGYDGPRPAIERVRYLAAGRSETRALMAEGGQADLAYGLDPASLVRLRKRGQVRVDTVTLPRTVILKVNAGLPALNDVRVRQALSLAIDRAGIAKALLRDPELAATQLFPPTMAAWHNNALPALKQDPDAAARLLAEAGWRRAPDGLRDASGQPLRLSLRTFPDRPELPLIASALQEQWRQAGIAVQVSIGNSGDIPLGHRDGSLQLGLAARNYATVPDPTGTLMQDFGTSGGDWGAMGWRSDAVARALAELSRGTSSAERAAALRTQVTAVLHAELPVIPITWYRQQVAVGRRLEGVSLDPLERSYRLTAMRWRA
>NC_014931.1|WP_049794541.1|4449855_4450833_+|ABC-transporter-permease
MTPDITRTHTAWTAMLLRRAIQIFALGLLVGTVCFFMARSLPGDMATRIAAGRYGYDLVSNAAADAVRLELGLDRPLWLALLHWWGDIARLDLGTSLVSGHAVWREVAHQLAATIELAVASVFVAAVVGLPLGIWSGLHAGGWVDRFTLALAVVLRALPPFLLAVLLMVVVAVQLGAVPVAGDDHGGSLLLPALTLGLGLAAGLARVARSAMGEAAASASFEFARTKGLSDRQALVRHGLRQAATPVVAYLGVHAVFLVEGAVVVEALFAWPGIGHALVHAVFGRDVPMIQGAALCMGLLFVVFNLLVDAACLALDPRRRMGAVA
>NC_014931.1|WP_013542507.1|4450829_4451672_+|ABC-transporter-permease
MNGSVIDMPALDLAGHGARRTAIRRRAGLVILALVSAFSLFGPSLIGIDPARQTLANTLLPPGAAHWLGTDVLGRSVLARLAHAARLSLGLALLAALTAAVPGVLLGVAASWRGGRIERALVMLADAVLSVPGLLLVLLFAALAPGQHWALYIGLSLSLWVEYFRVCRAASRQVLASDAVQASRLLGFGTGYVLRRHLLPALAPVLGTLLAFSAAQAVLALAALGFIGVGLQPPTPELGLMMTEFLPHYEEAPWLIAAPVALLMAVVLGMMLVAGDGETT
>NC_014931.1|WP_013542508.1|4451668_4453078_+|ABC-transporter-ATP-binding-protein
MTASVLLAADNLGVHVGTRALLRDVSFSLRAGEVLTLLGESGAGKSLLAQAVMGNLPAALRASGSVTLDGATSRADDARARRPRWGRTVTLLPQEPSLALDPLMRIAPQLSETHELVRGAAFDQAEAAALHDLEAEGLAASARQYPWQLSGGMAQRAAAAVACAGGARILLADEPTKGLDAHWRDHTVAMLQGVQRRGGCVVVITHDLRVAEALGGQLIVLCAGQVVERGDARTVLADPQHAFTRRLVAADPARWPRRAAAPASAGAPVLSAQGLSKRFGGKPLFDGVDLQIRAGDRFVVQGPSGTGKSTLGNVLLGLMPADRGVVRRAEGLHATAFQKLYQDPVASFAPHVTLGQSLRDVAARHRCAWPAVLQHLSRMGVPHDLLARRPSQVSGGELQRVALARVLTVQPALVFADEPTSRLDPVSQQEAMAVLLDALDERGAALMLVTHDDDIADAVATQRWRLAAG
>NC_014931.1|WP_013542509.1|4453685_4455080_-|hypothetical-protein
MIRKSIPLNTARLLWAQCGGFCQNPECNEYLFRLIDEDMVSLANVAHIIGHGSSGPRSDHELAEHINKDGVENLVMLCLGCHKVIDELEQKFSVEEIISWKFSHANKIAGLFEIPSIRDENTLLKDINDLLDENAAIFREYGPYSENVLSGMGGDGLRVWRSRCLNTILPNNQRIIQIIEKNKRNFPYPWDIYSQMLLYKMHVDAFQDNCLSNNKINDYKLFPRSFDYLVKTKLNIPSEPPQIVAREELEYRFNQVNTFIERFLSNHDRIARLQELNRGTMLVDLKDGNALKVFVTNTYYFTDYTLDRVLEVDPAINAIICSSPAGQYSESAKTCCIEKGIGLFMLGEFMGAIRHNGENYLNFLLRADSEARSVGLKRILKNIQPPARICVYAFGSFLRRRVYRDVDLLIVYEGVANIAAVKNFESLLFSEVQKQFGQPDITVASTEEFSNLKLKYNNLTQVYP
>NC_014931.1|WP_144299019.1|4455634_4456561_+|hypothetical-protein
MTYVKLVWPHLRAPASQRSQDAATEFEVPYTRELWPLINSILTLAAKGDPAGILDPQIGRYVKRRQEFSPNFGCKTAFKAVASFFDDIFHPAIGRLRHPLRYFAQAQIQIYSAEMKRFGDFYRNEIEQPNIERYLATLNDYFKHFDQFRQMLVHARVGDNEVDDFVVGSKSFNEIKLYYGQAYETLTSSYLTLACINNVAQGRPYDEFQSMTLSKYTKDLEKSKRSNPFKETPELAAFIRFEDSSLRNGSHHASIWRDGEIVKYKSGGTGAERDISYSRYLHQCNEITIALAALLLVELQMFSRLRPS
>NC_014931.1|WP_013542511.1|4456678_4456978_-|hypothetical-protein
MAKQIIAGRSTPKSPSRRSGARSSTTTPSGAPPSPPTGNDARDLLEEKLTQLHSLLWCAYGDGNGWFEEAGEMHRGNMMWIAADLARAADELLQASVKG
>NC_014931.1|WP_013542512.1|4457734_4458367_+|PadR-family-transcriptional-regulator
MRHPHFGHHHHNHHCHAPRGEHGDGFSGGRGRHGHGEGDLGDDQRMPGGRGGRGGGRVFGHGGLRFVLLQLIADKPSHGYELIKAIEDRLGGSYAPSPGVVYPTLTLLEEMGHLSVETADTGGRKRYSITPGGQEFLAANRETADAMMARMTGGVDGAGPRGGRPPQVTRAIENLKLAMRMRLSGTPLTEQQAHDFAAVLDSAAQQLERI

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

700982 : 709559

Acinetobacter_phage(42.86%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013539095.1\|700982_702485_+	anthranilate synthase component I	A0A0B5J984	Pandoravirus	2.3e-35	29.1
WP_013539096.1\|702546_702939_+	GxxExxY protein	A9YW17	Ostreococcus_tauri_virus	2.3e-06	32.0
WP_013539097.1\|702935_703520_+	aminodeoxychorismate/anthranilate synthase component II	A0A0P0IKJ1	Acinetobacter_phage	1.1e-57	57.4
WP_013539098.1\|703526_704585_+	low-specificity L-threonine aldolase	NA	NA	NA	NA
WP_013539099.1\|704601_705261_+	LysE family translocator	NA	NA	NA	NA
WP_013539100.1\|705288_706311_+	anthranilate phosphoribosyltransferase	A0A0N7IRD9	Acinetobacter_phage	3.9e-74	45.3
WP_013539101.1\|706340_707141_+	indole-3-glycerol phosphate synthase TrpC	A0A0P0IR83	Acinetobacter_phage	7.5e-57	50.2
WP_013539102.1\|707137_707845_+	uracil-DNA glycosylase	A0A0B5IW78	Pandoravirus	7.3e-48	46.2
WP_013539103.1\|708365_709559_+	elongation factor Tu	A0A1V0SLW6	Klosneuvirus	2.6e-13	29.2

DBSCAN-SWA_2

1555155 : 1564399

Streptococcus_phage(16.67%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013539856.1\|1555155_1556058_+	cysteine synthase CysM	A0A1X9I5F1	Streptococcus_phage	3.2e-56	43.1
WP_013539857.1\|1556123_1556702_+	NUDIX domain-containing protein	NA	NA	NA	NA
WP_013539858.1\|1556691_1556919_+	sulfurtransferase TusA family protein	NA	NA	NA	NA
WP_013539859.1\|1556987_1557878_-	UTP--glucose-1-phosphate uridylyltransferase GalU	A0A127AW70	Bacillus_phage	1.4e-67	49.0
WP_013539860.1\|1557978_1560858_-\|tRNA	valine--tRNA ligase	A0A1V0SK04	Klosneuvirus	2.4e-145	39.6
WP_013539861.1\|1560974_1561757_+	peroxide stress protein YaaA	NA	NA	NA	NA
WP_013539862.1\|1561756_1562599_+	hypothetical protein	A0A1J0F982	Only_Syngen_Nebraska_virus	1.5e-18	34.2
WP_013539863.1\|1562612_1563527_+	alpha/beta hydrolase	A0A2D1GCA0	Mycobacterium_phage	1.0e-09	27.1
WP_013539864.1\|1563523_1564399_+	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	A0A2I7SAX1	Vibrio_phage	2.6e-42	38.2

DBSCAN-SWA_3

2174636 : 2182263

Pseudomonas_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013540426.1\|2174636_2175566_-	yqaj viral recombinase family	A0A0U2BXF3	Paracoccus_phage	1.6e-18	36.6
WP_080559441.1\|2175562_2176288_-	ERF family protein	Q9MC70	Pseudomonas_phage	8.7e-20	38.8
WP_013540428.1\|2176374_2176611_-	hypothetical protein	NA	NA	NA	NA
WP_013540430.1\|2176723_2176915_-	hypothetical protein	NA	NA	NA	NA
WP_144298960.1\|2176911_2177667_-	methyltransferase	A0A1Y0T2N3	Pseudomonas_phage	1.4e-09	35.4
WP_013540432.1\|2177782_2177980_-	hypothetical protein	NA	NA	NA	NA
WP_013540433.1\|2178156_2178888_-	helix-turn-helix transcriptional regulator	Q8W6P8	Burkholderia_virus	5.9e-24	68.6
WP_080559442.1\|2178974_2179262_+	hypothetical protein	NA	NA	NA	NA
WP_013540434.1\|2179373_2179634_-	hypothetical protein	NA	NA	NA	NA
WP_013540435.1\|2179733_2179913_+	hypothetical protein	NA	NA	NA	NA
WP_013540436.1\|2179940_2180255_+	hypothetical protein	NA	NA	NA	NA
WP_013540437.1\|2180254_2181421_+	site-specific DNA-methyltransferase	Q8W6P4	Burkholderia_virus	9.1e-112	55.8
WP_013540438.1\|2181417_2182263_+	hypothetical protein	A0A291LAU4	Bordetella_phage	5.7e-31	33.1

DBSCAN-SWA_4

2213192 : 2230021

Pseudomonas_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013540472.1\|2213192_2222513_+	PLxRFG domain-containing protein	A0A0U1T6E4	Pseudomonas_phage	0.0e+00	61.6
WP_013540473.1\|2223620_2223977_+	hypothetical protein	A0A218M354	Acidovorax_phage	1.0e-21	54.7
WP_013540474.1\|2223973_2226487_+	hypothetical protein	Q5ZGD1	Flavobacterium_phage	7.2e-29	62.4
WP_013540475.1\|2226483_2226657_+	hypothetical protein	NA	NA	NA	NA
WP_013540476.1\|2226697_2226967_+	hypothetical protein	NA	NA	NA	NA
WP_013540477.1\|2226966_2227518_+	lysozyme	L7TJR2	Pseudomonas_virus	2.5e-59	62.6
WP_080559445.1\|2227550_2228051_+	DUF2514 family protein	Q3HQV1	Burkholderia_phage	6.9e-08	38.0
WP_013540479.1\|2228051_2228303_-	hypothetical protein	NA	NA	NA	NA
WP_049794385.1\|2228332_2228596_-	hypothetical protein	NA	NA	NA	NA
WP_013540481.1\|2228995_2230021_-	hypothetical protein	I6NRL3	Burkholderia_virus	1.2e-62	44.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_014931

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CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection