CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_017450	Francisella cf. novicida Fx1, complete genome	2 crisprs	RT,cas3,csa3,cas9,DEDDh,cas2,cas1,cas4,cas12a	0	2	4	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_017450_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017450_1

787360-787745

TypeII

Consensus_repeat	Method
CTAACAGTAGTTTACCAAATAATTCAGCAACTGAAAC	PILER-CR
CTAACAGTAGTTTACCAAATAATTCAGCAACTGAAAC	CRISPRCasFinder
CTAACAGTAGTTTACCAAATAATTCAGCAACTGAAAC	CRT

5 spacers

cas9

The CRISPR arrays of NC_017450_1

>merge|NC_017450|1|787360-787745|PILER-CR,CRISPRCasFinder,CRT
CTAACAGTAGTTTACCAAATAATTCAGCAACTGAAACTCTGGATGTAGTAACCAAGTCTTACGCTCGATAACTAACAAATAATTCAGCAACTGAAACGTTGGATCTGTCTCTCTCATTAATACAAGATTGTATCTAACAGTAGTTTACCAAATAATTCAGCAACTGAAACAATAAAGAAAATGTAGACTTATTCCAAAACGTTACTAACAGTAGTTTACCAAATAATTCAGCAACTGAAACAGCTTCTCATATATGTATTTACTGTCGATTTGATCTAACAGTAGTTTACCAAATAATTCAGCAACTGAAACTTTTAATAGGTGATTTGTGAATTTTGATGAGTTAAAGCTAACAGTAGTTTACCAAATAATTCAGCAACTGAAAC

>NC_017450|1|1|787360-787745|PILER-CR
CTAACAGTAGTTTACCAAATAATTCAGCAACTGAAAC	TCTGGATGTAGTAACCAAGTCTTACGCTCGATAAC
TAACAAATAATTCAGCAACTGAAACGTTGGATCTGTC	TCTCTCATTAATACAAGATTGTATCTAACAGTAGTT
TACCAAATAATTCAGCAACTGAAACAATAAAGAAAAT	GTAGACTTATTCCAAAACGTTACTAACAGTAGTT
TACCAAATAATTCAGCAACTGAAACAGCTTCTCATAT	ATGTATTTACTGTCGATTTGATCTAACAGTAGTT
TACCAAATAATTCAGCAACTGAAACTTTTAATAGGTG	ATTTGTGAATTTTGATGAGTTAAAGCTAACAGTAGTT
TACCAAATAATTCAGCAACTGAAAC

>NC_017450|1|1|787360-787745|CRISPRCasFinder
CTAACAGTAGTTTACCAAATAATTCAGCAACTGAAAC	TCTGGATGTAGTAACCAAGTCTT
ACGCTCGATAACTAACAAATAATTCAGCAACTGAAAC	GTTGGATCTGTCTCTCTCATTAATACAAGATTGTAT
CTAACAGTAGTTTACCAAATAATTCAGCAACTGAAAC	AATAAAGAAAATGTAGACTTATTCCAAAACGTTA
CTAACAGTAGTTTACCAAATAATTCAGCAACTGAAAC	AGCTTCTCATATATGTATTTACTGTCGATTTGAT
CTAACAGTAGTTTACCAAATAATTCAGCAACTGAAAC	TTTTAATAGGTGATTTGTGAATTTTGATGAGTTAAAG
CTAACAGTAGTTTACCAAATAATTCAGCAACTGAAAC

>NC_017450|1|1|787360-787745|CRT
CTAACAGTAGTTTACCAAATAATTCAGCAACTGAAAC	TCTGGATGTAGTAACCAAGTCTT
ACGCTCGATAACTAACAAATAATTCAGCAACTGAAAC	GTTGGATCTGTCTCTCTCATTAATACAAGATTGTAT
CTAACAGTAGTTTACCAAATAATTCAGCAACTGAAAC	AATAAAGAAAATGTAGACTTATTCCAAAACGTTA
CTAACAGTAGTTTACCAAATAATTCAGCAACTGAAAC	AGCTTCTCATATATGTATTTACTGTCGATTTGAT
CTAACAGTAGTTTACCAAATAATTCAGCAACTGAAAC	TTTTAATAGGTGATTTGTGAATTTTGATGAGTTAAAG
CTAACAGTAGTTTACCAAATAATTCAGCAACTGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_017450.1\|WP_014549642.1\|775131_776505_+\|L-serine-ammonia-lyase	unknown	unknown	gnl\|CDD\|273233
NC_017450.1\|WP_014549641.1\|774407_775076_+\|M48-family-metallopeptidase	unknown	unknown	gnl\|CDD\|307807
NC_017450.1\|WP_003033618.1\|791816_792569_-\|RNA-methyltransferase	unknown	unknown	gnl\|CDD\|349968
NC_017450.1\|WP_003016538.1\|777851_778208_+\|iron-sulfur-cluster-assembly-accessory-protein	unknown	unknown	gnl\|CDD\|223393
NC_017450.1\|WP_014549643.1\|776607_777831_+\|SufS-family-cysteine-desulfurase	unknown	unknown	gnl\|CDD\|131034
NC_017450.1\|WP_014549652.1\|795260_796115_+\|bifunctional-methionine-sulfoxide-reductase-B/A-protein	unknown	unknown	gnl\|CDD\|235499
NC_017450.1\|WP_014549648.1\|790236_790590_-\|hypothetical-protein	unknown	unknown	unknown
NC_017450.1\|WP_014549649.1\|790754_791723_-\|linear-amide-C-N-hydrolase	unknown	unknown	gnl\|CDD\|225591
NC_017450.1\|WP_003016533.1\|779277_779523_+\|YfhL-family-4Fe-4S-dicluster-ferredoxin	unknown	unknown	gnl\|CDD\|235941
NC_017450.1\|WP_003036235.1\|779629_780811_+\|OmpA-family-protein	unknown	unknown	gnl\|CDD\|143586
NC_017450.1\|WP_014549650.1\|792710_794663_+\|BCCT-family-transporter	unknown	unknown	gnl\|CDD\|376718
NC_017450.1\|WP_014549647.1\|788451_789537_+\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|275338
NC_017450.1\|WP_014549651.1\|794655_795132_-\|tryptophan-rich-sensory-protein	unknown	unknown	gnl\|CDD\|320706
NC_017450.1\|WP_014549653.1\|796111_797314_-\|multidrug-effflux-MFS-transporter	unknown	unknown	gnl\|CDD\|340878
NC_017450.1\|WP_014549645.1\|781483_786373_+\|type-II-B-CRISPR-associated-RNA-guided-endonuclease-Cas9/Csx12	cas9	cd09704_cas9_CAS-II-B	gnl\|CDD\|274401
NC_017450.1\|WP_003036243.1\|789774_790224_+\|acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|223894
NC_017450.1\|WP_014549640.1\|773539_774382_+\|prephenate-dehydratase	unknown	unknown	gnl\|CDD\|223155
NC_017450.1\|WP_003036232.1\|778784_779273_+\|pantetheine-phosphate-adenylyltransferase	unknown	unknown	gnl\|CDD\|234674
NC_017450.1\|WP_003033610.1\|789529_789778_+\|glutaredoxin	unknown	unknown	gnl\|CDD\|239510
NC_017450.1\|WP_003036229.1\|778221_778773_+\|putative-Fe-S-cluster-assembly-protein-SufT	unknown	unknown	gnl\|CDD\|213809

Protein	Function_ID	Function_description	E-value
NC_017450.1\|WP_014549642.1\|775131_776505_+\|L-serine-ammonia-lyase	gnl\|CDD\|273233	TIGR00720, hypothetical_protein_NEICINOT_00681, L-serine dehydratase, iron-sulfur-dependent, single chain form. This enzyme is also called serine deaminase and L-serine dehydratase 1. L-serine ammonia-lyase converts serine into pyruvate in the gluconeogenesis pathway from serine. This enzyme is comprised of a single chain in Escherichia coli, Mycobacterium tuberculosis, and several other species, but has separate alpha and beta chains in Bacillus subtilis and related species. The beta and alpha chains are homologous to the N-terminal and C-terminal regions, respectively, but are rather deeply branched in a UPGMA tree. This enzyme requires iron and dithiothreitol for activation in vitro, and is a predicted 4Fe-4S protein. Escherichia coli Pseudomonas aeruginosa have two copies of this protein. [Energy metabolism, Amino acids and amines, Energy metabolism, Glycolysis/gluconeogenesis].	0
NC_017450.1\|WP_014549641.1\|774407_775076_+\|M48-family-metallopeptidase	gnl\|CDD\|307807	pfam01863, DUF45, Protein of unknown function DUF45. This protein has no known function. Members are found in some archaebacteria, as well as Helicobacter pylori. The proteins are 190-240 amino acids long, with the C-terminus being the most conserved region, containing three conserved histidines. This motif is similar to that found in Zinc proteases, suggesting that this family may also be proteases.	1.05321e-50
NC_017450.1\|WP_003033618.1\|791816_792569_-\|RNA-methyltransferase	gnl\|CDD\|349968	cd18095, SpoU-like_rRNA-MTase, SAM-dependent rRNA methylase related to SpoU-TrmH. RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.	6.30882e-53
NC_017450.1\|WP_003016538.1\|777851_778208_+\|iron-sulfur-cluster-assembly-accessory-protein	gnl\|CDD\|223393	COG0316, sufA, Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones].	1.01145e-25
NC_017450.1\|WP_014549643.1\|776607_777831_+\|SufS-family-cysteine-desulfurase	gnl\|CDD\|131034	TIGR01979, Probable_cysteine_desulfurase, cysteine desulfurases, SufSfamily. This model represents a subfamily of NifS-related cysteine desulfurases involved in FeS cluster formation needed for nitrogen fixation among other vital functions. Many cysteine desulfurases are also active as selenocysteine lyase and/or cysteine sulfinate desulfinase. This subfamily is associated with the six-gene SUF system described in E. coli and Erwinia as an FeS cluster formation system during oxidative stress. The active site Cys is this subfamily resembles GHHC with one or both His conserved. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	0
NC_017450.1\|WP_014549652.1\|795260_796115_+\|bifunctional-methionine-sulfoxide-reductase-B/A-protein	gnl\|CDD\|235499	PRK05550, PRK05550, bifunctional methionine sulfoxide reductase B/A protein; Provisional.	4.43088e-180
NC_017450.1\|WP_014549649.1\|790754_791723_-\|linear-amide-C-N-hydrolase	gnl\|CDD\|225591	COG3049, COG3049, Penicillin V acylase and related amidases [Cell envelope biogenesis, outer membrane].	2.50174e-68
NC_017450.1\|WP_003016533.1\|779277_779523_+\|YfhL-family-4Fe-4S-dicluster-ferredoxin	gnl\|CDD\|235941	PRK07118, PRK07118, Fe-S cluster domain-containing protein.	1.36021e-07
NC_017450.1\|WP_003036235.1\|779629_780811_+\|OmpA-family-protein	gnl\|CDD\|143586	cd07185, OmpA_C-like, Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA. OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.	6.60546e-21
NC_017450.1\|WP_014549650.1\|792710_794663_+\|BCCT-family-transporter	gnl\|CDD\|376718	pfam02028, BCCT, BCCT, betaine/carnitine/choline family transporter.	0
NC_017450.1\|WP_014549647.1\|788451_789537_+\|radical-SAM-protein	gnl\|CDD\|275338	TIGR04545, rSAM_ahbD_hemeb, heme b synthase. Members of this family are AhbD (alternative heme biosynthetic protein D), a radical SAM enzyme in sulfate-reducing bacteria and methanogens that performs the last decarboxylations to synthesize heme b from Fe-coproporphyrin III. Members include DVU_0855, previously included in error in TIGR04055, the NirJ2 family thought to be involved in heme d1 biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin].	4.74364e-140
NC_017450.1\|WP_014549651.1\|794655_795132_-\|tryptophan-rich-sensory-protein	gnl\|CDD\|320706	cd15904, TSPO_MBR, Translocator protein (TSPO)/peripheral-type benzodiazepine receptor (MBR) family. This family contains tryptophan-rich translocator protein (TSPO), an integral membrane protein that is highly conserved from bacteria to mammals. In eukaryotes, it is mainly found in the outer mitochondrial membranes of steroid-synthesizing cells of the nervous system where it transports cholesterol into mitochondria. It is known to be highly expressed in metastatic cancer, steriodogenic tissues, as well as inflammatory and neurological diseases such as Alzheimer's and Parkinson's. TSPO is also known as the peripheral benzodiazepine receptor (MBR) and its ligands include benzodiazepine drugs, implicated in regulating apoptosis. In human, a single polymorphism A147T is associated with psychiatric disorders; the mutation causes structural changes in a region implicated in cholesterol binding. TSPO is homologous to bacterial tryptophan-rich sensory proteins, and their tryptophan residues are believed to be functionally important. In bacteria, TSPO acts as a negative regulator of expression of specific photosynthesis genes in response to oxygen/light; it catalyzes a photooxidative degradation of Proto porphyrine (PpIX). R. sphaeroides TSPO (RsTSPO) is involved in porphyrin transport, similar to human, while Arabidopsis translocator protein (AtTSPO) is regulated at multiple levels in response to salt stress and perturbations in tetrapyrrole metabolism.	5.73436e-41
NC_017450.1\|WP_014549653.1\|796111_797314_-\|multidrug-effflux-MFS-transporter	gnl\|CDD\|340878	cd17320, MFS_MdfA_MDR_like, Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.32394e-74
NC_017450.1\|WP_014549645.1\|781483_786373_+\|type-II-B-CRISPR-associated-RNA-guided-endonuclease-Cas9/Csx12	gnl\|CDD\|274401	TIGR03031, cas_csx12, CRISPR system subtype II-B RNA-guided endonuclease Cas9/Csx12. Members of this family of CRISPR-associated (cas) protein are found, so far, in CRISPR/cas loci in Wolinella succinogenes DSM 1740, Legionella pneumophila str. Paris, and Francisella tularensis, where the last probably is an example of a degenerate CRISPR locus, having neither repeats nor a functional Cas1. The characteristic repeat length is 37 base pairs and period is about 72. One region of this large protein shows sequence similarity to pfam01844, HNH endonuclease.	0
NC_017450.1\|WP_003036243.1\|789774_790224_+\|acyl-CoA-thioesterase	gnl\|CDD\|223894	COG0824, FcbC, Predicted thioesterase [General function prediction only].	2.54542e-26
NC_017450.1\|WP_014549640.1\|773539_774382_+\|prephenate-dehydratase	gnl\|CDD\|223155	COG0077, PheA, Prephenate dehydratase [Amino acid transport and metabolism].	7.86864e-98
NC_017450.1\|WP_003036232.1\|778784_779273_+\|pantetheine-phosphate-adenylyltransferase	gnl\|CDD\|234674	PRK00168, coaD, phosphopantetheine adenylyltransferase; Provisional.	4.2984e-85
NC_017450.1\|WP_003033610.1\|789529_789778_+\|glutaredoxin	gnl\|CDD\|239510	cd03418, GRX_GRXb_1_3_like, Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide reductase. It contains a redox active CXXC motif in a TRX fold and uses a similar dithiol mechanism employed by TRXs for intramolecular disulfide bond reduction of protein substrates. Unlike TRX, GRX has preference for mixed GSH disulfide substrates, in which it uses a monothiol mechanism where only the N-terminal cysteine is required. The flow of reducing equivalents in the GRX system goes from NADPH -> GSH reductase -> GSH -> GRX -> protein substrates. By altering the redox state of target proteins, GRX is involved in many cellular functions including DNA synthesis, signal transduction and the defense against oxidative stress. Different classes are known including E. coli GRX1 and GRX3, which are members of this subfamily.	1.16836e-12
NC_017450.1\|WP_003036229.1\|778221_778773_+\|putative-Fe-S-cluster-assembly-protein-SufT	gnl\|CDD\|213809	TIGR03406, FeS_long_SufT, probable FeS assembly SUF system protein SufT. The function is unknown for this protein family, but members are found almost always in operons for the the SUF system of iron-sulfur cluster biosynthesis. The SUF system is present elsewhere on the chromosome for those few species where SUF genes are not adjacent. This family shares this property of association with the SUF system with a related family, TIGR02945. TIGR02945 consists largely of a DUF59 domain (see pfam01883), while this protein is about double the length, with a unique N-terminal domain and DUF59 C-terminal domain. A location immediately downstream of the cysteine desulfurase gene sufS in many contexts suggests the gene symbol sufT. Note that some other homologs of this family and of TIGR02945, but no actual members of this family, are found in operons associated with phenylacetic acid (or other ring-hydroxylating) degradation pathways. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	1.74664e-98

>NC_017450.1|WP_014549645.1|781483_786373_+|type-II-B-CRISPR-associated-RNA-guided-endonuclease-Cas9/Csx12
MNFKILPIAIDLGVKNTGVFSAFYQKGTSLERLDNKNGKVYELSKDSYTLLMNNRTARRHQRRGIDRKQLVKRLFKLIWTEQLNLEWDKDTQQAISFLFNRRGFSFITDGYSPEYLNIVPEQVKAILMDIFDDYNGEDDLDSYLKLATEQESKISEIYNKLMQKILEFKLRKLCTDIKDDKVSTKTLKEITSYEFELLADYLANYSEILKTQKFSYTDKQGNLKELSYYHHDKYNIQEFLKRHATINIQILDTLLTDDLDIWNFNFEKFDFDKNEEKLQNQEDKDHIQAHLHHFVFAVNKIKSEMASGGRHRSQYFQEITNVLDENNHQEGYLKNFCENLHNKKYSNLSVKNLVNLIGNLSNLELKPLRKYFNDKIHAKADHWDEQKFTETYCHWILGEWRVGVKDQDKKDGAKYSYKDLCNELKQKVTKAGLVDFLLELDPCRTIPPYLDNNNRKPPKCQSLILNPKFLDNQYPNWQQYLQELKKLQSIQNYLESFETDLKVLKSSKDQPYFVEYRSSNQQIASGQRDYKDLDARILQFIFDRVKASDELLLNEIYFQAKKLKQKASSELEKLESSKKLDEVIANSQLSQILKSQHTNGIFEQGTFLHLVCKYYKQRQRARDSRLYIMPEYRYDKKLHKYNNTGRFDDDNQLLTYCNHKPRQKRYQLLNDLAGVLQVSPNFLKDKIGSDDDLFISKWLVEHIRGFKKACEDSLKIQKDNRGLLNHKINIARNTKGKCEKEIFNLICKIEGSEDKKGNYKHGLAYELGVLLFGEPNEASKPEFDRKIKKFNSIYSFAQIQQIAFAERKGNANTCAVCSADNAHRMQQIKITEPVEDNKDKIILSAKAQRLPAITTRIVDGAVKKMATILAKNIVDDNWQNIKQVLSAKHQLHIPIITESNAFEFEPALADVKGKSLKDRRKKALERISPENIFKDKNNRIKEFAKGISAYSGANLTDGDFDGAKEELDHIIPRSHKKYGTLNDEANLICVTRGDNKNKGNRIFCLRDLANNYKLKQFETTDDLEIEKKIADTIWDANKKDFKFGNYRSFINLTPQEQKAFRHALFLADENPIKQAVIRAINNRNRTFVNGTQRYFAEVLANNIYLRAKKENLNTDKISFDYFGIPTIGNGRGIAEIRQLYEKVDSDIQAYAKGDKPQASYSHLIDAMLAFCIAADEHRNDGSIGLEIDKNYSLYPLDKNTGEVFTKDIFSQIKITDNEFSDKKLVRKKATEGFNTHRQMTRDGIYAENYLPILIHKELDEVRKGYTWKNSEEIKIFKGKKYDIQQLNNLLYCLKFVDKPISIDIQISTLEELRNILTTNNIAATAEYYYINLKTQKLHEYYIENYNTALGYKKYTKEMEFLRSLAYRSERVKIKSIDDVKQVLDKDSNFIIGKITLPFKKEWQRLYREWQNITIKDDYEFLKSFFNVKSITKLHKKVRKDFSLPISTNEGKFLVKRKTWDNNFIYQILNDSDSRVDGTKPFIPAFDISKNEIVEAIIDSFTSKNIFWLPKNIELQKVDNKNIFAIDTSKWFEVETPSDLRDIGVATIQYKIDNNSRPKVRVKLDYVIDDDSKINYFTNHSLLKSRYPDKVLEILKQSTIIEFESSGFNKTIKEMLGMTLAGIYNETSNN
>NC_017450.1|WP_003036235.1|779629_780811_+|OmpA-family-protein
MMRLKSIVIATTVLLGSATASIAAGSDNIDTSANTNSATTQSSGFAANNFIAPFANTYSALTNKDNTWGPQDRTGQWYLGVDANGLAGTPNSPSGAGANFTIGYNINKYFAVQYNQLVGRVFAGLGEGVVNFSNNTMFTPYAAGGAGWANLAGQATGAWDVGGGLKFELSRNVQASVDYRYIQTMAPSNISGANGRAGTNMIGAGLTWFFGGKDTTNNDTGNIQDNGATTAAQTVAMPTIDESKYVLPAGIKQCEGNFNLTEDGVACYTVNGDDVTVYLDTKFAYDKATLNAKGKKAIASFVNFIKDSNIGSVTVKGYASQGQTSSEFDIYNQKLSEKRAQAVADYMKQLGLDSEKIITKGFGYDDTLGGIPKSDPRNQRVEASVSAPLKEAN
>NC_017450.1|WP_003016533.1|779277_779523_+|YfhL-family-4Fe-4S-dicluster-ferredoxin
MALLITDECINCDICEPECPNEAISQGEEYYEIDPNKCTECVGHFEESQCTKVCPIRCIIIDPNNIETHQQLLDKYNSLVS
>NC_017450.1|WP_003036232.1|778784_779273_+|pantetheine-phosphate-adenylyltransferase
MNKIAIYPGTFDPITNGHVDLVERALNIFDEIVVAVSTAYGKNTLFDICIREQMIKEVFKDNQRVKVVSFQGLLVDTAVKHNACAIVRGLRAVSDFDYEFQMSSMNNKLNSDIQTIFLTPSEKFSCISSTLVRAVAIHNYKRVDEFVPECVFREIKLKYSKE
>NC_017450.1|WP_003036229.1|778221_778773_+|putative-Fe-S-cluster-assembly-protein-SufT
MKPTDVTIIRRQVKAIAVPFGNEIELMPGQEVLVTQDKGGSFTLNVNGNLLHLDGKDADAIGKQIVRYPVEEYDIKPGDPINMDAIWDQMRTVYDPEIPVNIVDLGLIYNIVTRKLENGNFHVIIDMTLTAPGCGMGPVLMTDVEKRVAMLPNVDKVDVVMVFDPPWNSEMMTEAAKLELGLF
>NC_017450.1|WP_003016538.1|777851_778208_+|iron-sulfur-cluster-assembly-accessory-protein
MVEVFDPNASSILEVTDAAAKHFKKHLDKHDGCIGIYVGTKVMGCSGLAYDVDFVKQQPQDTQKVQQHGINFFVSNKSMDFLNGLKIDYVKHDFGLYKLEYTNPNESARCGCGESFTV
>NC_017450.1|WP_014549643.1|776607_777831_+|SufS-family-cysteine-desulfurase
MYDVNKIRQDFPFLVQKINNKSVLFFDTGASAQKPQAVIECVAEAYAYNYANVHRGVYSLSQEASEKYENVRQIVQKFLNSKSADEIVITKGTTEAINLVASSMGKGIIRSDDEIVVTEMEHHANFVPWQMLCEDKNLDFKVAAVKDNGELDVDNLLALVTAKTKILAITLCSNVLGTINPVKEIIKQVREINPNIIVLVDGAQAVIHTNVDVQDLDCDFFVFSGHKLYGPTGVGILYGKYELLKQLPPYNYGGDMVDEVTIVKTTFALPPYRFEAGTPNIVEAIGLGRAIEYVDSIGMINIEKHEQKLLEYATTELNKIDGLTIFGQAKHKAGVITFDIQGCNAGDIGELLAIKGICVRTGKHCAHPLMYRMGATSTVRMSFGMYNTFEEIDLFIIALKKVISQLK
>NC_017450.1|WP_014549642.1|775131_776505_+|L-serine-ammonia-lyase
MESTFELFSIGVGPSSSHTIGPMRAGCDFINLYKDKLPQTKRVKIDLFGSLALTGKGHKTDYAVVLGVMGFLPESVDIELAKKLYDECLRNKKLNLGQEFEIDFDYDKDLVFHYNEFLPEHANGMRFSLFNGEELLCEKEYFSIGGGFIVDKKQIKKDTVPTEVSCDKPYKFSTMAELRELCQRDNKTIDEIMFENEKTAYGEQQSLDKLAEIWHVMETSIEKGLTCAEATLPGGLKVRKRAPSMIRKLKEQNIVNTDFNYLNAFAIAVNEQNACGERVVTAPTNGAAGVIPAVLKYYLQTHEIVNQQELKEVVNKYLLVCAAIGILYKSGASISAAEVGCQGEVGVACSMAAAGYCALLGGDLDSIESAAEIGMEHNLGLTCDPIGGLVQIPCIERNAMGAVQAINAAKLAYLDTGEKRFVGLDYVIKVMYETGLDMSSKYKETSLGGLATNVPVC
>NC_017450.1|WP_014549641.1|774407_775076_+|M48-family-metallopeptidase
MSYKVKIIYRDVANLKISLNKDGLVTVVSPQKVTKKEIFKILESKKAWLDKHAKRLSVNQKYDYQNYTLNDGDSVYFLGREYPIKLVESKHNIVSYHDDHIQILLNPSVITNRQFKLQLLEEFYKDQADIILNNLVAKYLKITNQEITRVTIKKTKTRWGSCNYVKKTINLNFNLVLRDIQAIEYVVLHEIAHLTHPNHSKEFYAYVASYMPDWKVREKRLK
>NC_017450.1|WP_014549640.1|773539_774382_+|prephenate-dehydratase
MIKVSFQGEHGAYSEQAITNFLELQNIKDFQTVPCWSFSDAIEHTIIGKSNFVMIPVENSLAGSVVPAYDELIKSNLKVKAEVVLKIKHCLMGLNDVEISEIESVISHPQALSQCANSLKKLKLTPEAFVDTAGAAKYIFEKNKRNHLAIAGELAAKTYGLKIFQHELEDEQFNYTRFLLMGYDDIKVNSADNKYKTTIIFSVEDKSNALVNTLNVFGKYNINLTKIESRPSRNRAWNYLFFIDFEGSDDDLNVQQALLEVLKKSTFLKVLGSYKSYHFS
>NC_017450.1|WP_014549647.1|788451_789537_+|radical-SAM-protein
MKHQLKWMAWETTRRCNLKCVHCRSSSDCEVLGHPDFSTEEGFRIIDSIVAFANPVLVLSGGEPLLRADIFELAEYGANKGLRMALATNGSLVTDEICEKIKNANISIVSLSIDGATAETHDDFRNQKGAFEATINAAKLFRKHDIPFLINSSFTKRNQHEITDVYKLAKSLEATAWYLFMIVPTGRGEELIQELIDIDDYQDILNWHYDIEADEQDMLVRPTCAPHYYRIRFERNKEDNAKVRSRALSFGTGGGKGCIAGQSICLLDVDGNIYPCSYLPVSAGNIKEKSFADIWQNSNVLEDMRNFSAYEGKCGACEFIKICGGCRARAYNIHGNYLAEEPFCNHVPIRMRNIEEKQNNE
>NC_017450.1|WP_003033610.1|789529_789778_+|glutaredoxin
MNNFKSIVLYRMVTPEKICPYGLKAKALFEQKGWSFEDNHLKTRAETDAFKAKYNLQTTPLIFIDGQQIGGYSDLLEFLGEK
>NC_017450.1|WP_003036243.1|789774_790224_+|acyl-CoA-thioesterase
MNQQLKYFVLSTQVLPEHIDPNKHLNNIVYLQWMQDVAIAHVKANGVFELTESQGLTWFARKHTIEYLSQGFLGDDIAVVTWVESITKISTFRKYHIYRKSDKTLLCKADTLWVMVNAHRGKPAKIPTELVEIFDKYNNFEIDDIKNLI
>NC_017450.1|WP_014549648.1|790236_790590_-|hypothetical-protein
MSKCKTHQNHEHKHQDDCGHTKIKHGDHYDYLHDGHLHHEHNGHYDEHTLEVTKKNPDGCHPIKEDCSSHVHGPNCGHEAVPHGDHIDYIVDGRLHHPHGDHCDDHGPVEVIKNDKK
>NC_017450.1|WP_014549649.1|790754_791723_-|linear-amide-C-N-hydrolase
MLKKILITPLIILSFLQFSFGCTWFSFENDKEHYFIGRTMEWPGDLNTKITLVPRGYKFGNFTTHYGFVGMSHNGNFSDGMNEYGLAVSALWLSSSKYPDKKDADYNITMLLPYVLGNTTTVAQAVEFIKKHKFYTSVLPEISDKVEITVHFAISDAQGNSVVVEFINGKTKIYDNKIKVLTNDPAYDEQLKLLKKYQEGKFKEDKFIAFDYSSEGRFAKMAAFNITKANTPDDLTAVNHAWSIINTVDIPQGSLYWRWVSSKPQFTSYSVVGDLSNRVYYFRTWDNYDIRKVDLSKIDFAKAKYQADTIFGQADYQEFKFK
>NC_017450.1|WP_003033618.1|791816_792569_-|RNA-methyltransferase
MKNLSQKLYKEIKKLHSSQGRKKSQYYVIEGLRCSQEALKRLPQQQIIAILVTEKADNPNYPLNKKYIITEKDFEALSQTQNPQGVLILAEKPKLEELSFSDDFILVLDRIQDPGNIGTILRTAIAVGLKEVILINGTVDPFNPKAIRAGMGAQFSLKFSYITNLAELKNIAKLQQRKIWLTTPHQGVSCYAKEFKLANSILVFGEEANGIEDFSVGQKTMIPTLSDIESLNVAQAATIYLFEGLRQRLR
>NC_017450.1|WP_014549650.1|792710_794663_+|BCCT-family-transporter
MQRKKGAYAPVFYPAIVIAAILSLLGVLVPVAFANNIEIIQNLILEKFGWAYILAMSFFVCLCLILMFSRFGDIKLGQDHELPEYTNLSWFAMLFAAGMGIGLMFYGVAEPLNHFLSPPNLSPDSLETVKQAMNTTFFHWGIQAWSVYAVVGLSLAYFAYRHDLPLLPRSVLYPILGDKIYGVIGHAIDIFAILGTLFGVATSLGFGAMQVSSGISFLTGIADTQNMQVLYIIIIVALATISVALGLDKGIKALSNLNIVLAILLLAFILFLGNTAGLIRDYIQNIGYYLSTIVNQTFNLYAYNQDNQQWLKKWTLFYWGWWIAWSPFVGMFIAKVSKGRTIRQFIIGVLFIPVGFTFLWMTVFGNSAIEIVMTGKAQDLINAANNNIPVALFEFLQHFPFATILSILAVCLVVTFFVTSADSGALVIDILATGNAQASITVQRIAWSVLGGFLAISLILAGGLQALQSATIISAFPLLFILFLMAISLIKSLRLDYLRIKSIQTHSTVVQYVKADTSWQKRLSAIAAKPTKTQAIEFLQQVVTPAVLEVATEMQKNAINTEITKDDEHVQLIIRIESGDDFVYSVMLRSYQTKADNDTYNRVEVLLGHGGQYYDIIGYSKEQVIADIINQYDKHLHYLHLAVADKDIVN
>NC_017450.1|WP_014549651.1|794655_795132_-|tryptophan-rich-sensory-protein
MSQFKITNLISLVLFIIVILTIGYFVGMITSINIPSWFIYLESPFFAPPNWVFAPVWTILYIMIAISGWLIFQQHQLKEKTFIVYVIQLGLNFLWSFIFFCWHNIDLALLEMSILWVFVAWNIIIFRQINNLAGYLLVPYLLWISFAWILNFSYAVLN
>NC_017450.1|WP_014549652.1|795260_796115_+|bifunctional-methionine-sulfoxide-reductase-B/A-protein
MLKTKSLTPHEYDIIINKATEKPFTGRYNDLDQKGVYICRNCGTPLFRADSKFISACGWPSYDIHIDNNVKQLPDADGRRTEILCNNCDGHLGHIFHGEGYTKLNTRYCVNSACVDFIPIEDFGTTEEIIVAAGCFWGVEYYMKKLPGVLFAESGYCGGDQPYPDYKKVCQGDTGYLEVVRVIFDTSKVSLQQVIKYFFEIHDFEQVDGQGPDIGEQYKSAIFYYDDKQKQIAEDLKQILAQKGYKVATEIRAMKPYYVAEDYHLDYYMKKGTLPYCHSHKKIF
>NC_017450.1|WP_014549653.1|796111_797314_-|multidrug-effflux-MFS-transporter
MIGIRKGSKYLIFFVVIFVALPPFAIDAYIPAFGNIADFFNVNVNKVAITVSTYVVGFGIGMLFWGALSDRFGRKKILTIGMLIYIASSILCSLTHSFDTLILMRFLQGLGDSPAGVAAMAVLKDCYRGQKLMKMMATMVMVFMLAPIVAPIIGSLIIYTTGSWQDIFHFLTIYGVILLILTLIMPETHPSYKRSKNLVISFKTYLNHFMNIPFIFGGLTGGLCFGALFSFITASSNLIIGYFHLGYTQYCILFGLNICGVVFASNYIRRKVTAHNQRKLILNGYYFAIIITIINILSSYIFDNIYIFIFLNALLTIGLAFVNITTTSKVIDLLKEGFAAGNAVIRLVKFTVAGTAGFFLSFLSISKLMIGIPAQQLGFIVASLCLFLLIKHRLFPNQYH

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Crispr_ID: NC_017450_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017450_2

1468174-1468596

TypeV-A,TypeI-A

V-A

Consensus_repeat	Method
ATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC	CRISPRCasFinder
ATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC	CRT
ATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC	PILER-CR

6 spacers

csa3,cas2,cas1,cas4,cas12a

The CRISPR arrays of NC_017450_2

>merge|NC_017450|2|1468174-1468596|CRISPRCasFinder,CRT,PILER-CR
AATAATATAAAGACAAATTATTTAAAGTTCTTAGACGTAAACACTCCAGTTAAGTAATAATCCATATCTACAACAGTAGAAATTATTTAAAGTTCTTAGACAAATGTTTGAAAAAACGACAGAAGTGTTTATCTACAACAGTAGAAATTATTTAAAGTTCTTAGACAGTAGCTATTTGACCGAACGTACCCTTATATCTACAACAGTAGAAATTATTTAAAGTTCTTAGACCTACTTACTGGTTATTACGCTACGTTAGATCTACAACAGTAGAAATTATTTAAAGTTCTTAGACTTGGAAGAATATGCCAGTCCATATGTTAATCTACAACAGTAGAAATTATTTAAAGTTCTTAGACTTTGGAGTGGTTATTATGAAGAGATGGCATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC

>NC_017450|2|2|1468174-1468596|CRISPRCasFinder
AATAATATAAAGACAAATTATTTAAAGTTCTTAGAC	GTAAACACTCCAGTTAAGTAATAATCCAT
ATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC	AAATGTTTGAAAAAACGACAGAAGTGTTT
ATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC	AGTAGCTATTTGACCGAACGTACCCTTAT
ATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC	CTACTTACTGGTTATTACGCTACGTTAG
ATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC	TTGGAAGAATATGCCAGTCCATATGTTA
ATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC	TTTGGAGTGGTTATTATGAAGAGATGGC
ATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC

>NC_017450|2|2|1468174-1468596|CRT
AATAATATAAAGACAAATTATTTAAAGTTCTTAGAC	GTAAACACTCCAGTTAAGTAATAATCCAT
ATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC	AAATGTTTGAAAAAACGACAGAAGTGTTT
ATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC	AGTAGCTATTTGACCGAACGTACCCTTAT
ATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC	CTACTTACTGGTTATTACGCTACGTTAG
ATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC	TTGGAAGAATATGCCAGTCCATATGTTA
ATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC	TTTGGAGTGGTTATTATGAAGAGATGGC
ATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC

>NC_017450|2|2|1468239-1468596|PILER-CR
ATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC	AAATGTTTGAAAAAACGACAGAAGTGTTT
ATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC	AGTAGCTATTTGACCGAACGTACCCTTAT
ATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC	CTACTTACTGGTTATTACGCTACGTTAG
ATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC	TTGGAAGAATATGCCAGTCCATATGTTA
ATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC	TTTGGAGTGGTTATTATGAAGAGATGGC
ATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_017450.1\|WP_080558946.1\|1465514_1467209_-\|SidA/IucD/PvdA-family-monooxygenase	unknown	unknown	gnl\|CDD\|163244
NC_017450.1\|WP_080558945.1\|1463419_1464040_+\|2OG-Fe(II)-oxygenase	unknown	unknown	gnl\|CDD\|379309
NC_017450.1\|WP_014550096.1\|1474648_1475164_-\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|225695
NC_017450.1\|WP_003034662.1\|1478366_1479311_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133030
NC_017450.1\|WP_014550098.1\|1475894_1476584_-\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	unknown	unknown	gnl\|CDD\|234649
NC_017450.1\|WP_014550097.1\|1475168_1475885_-\|hypothetical-protein	unknown	unknown	unknown
NC_017450.1\|WP_080558969.1\|1469996_1470533_-\|type-V-CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	gnl\|CDD\|213941
NC_017450.1\|WP_003025316.1\|1461782_1462184_+\|hypothetical-protein	unknown	unknown	unknown
NC_017450.1\|WP_043024573.1\|1462933_1463380_+\|YcgN-family-cysteine-cluster-protein	unknown	unknown	gnl\|CDD\|235356
NC_017450.1\|WP_043024574.1\|1476653_1477289_+\|LysE-family-translocator	unknown	unknown	gnl\|CDD\|224199
NC_017450.1\|WP_014550093.1\|1468988_1469993_-\|type-V-CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|213942
NC_017450.1\|WP_003015040.1\|1464783_1465470_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293810
NC_017450.1\|WP_014550092.1\|1468735_1469008_-\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NC_017450.1\|WP_080558968.1\|1462245_1462713_+\|hypothetical-protein	unknown	unknown	unknown
NC_017450.1\|WP_014550090.1\|1464032_1464782_-\|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl\|CDD\|376667
NC_017450.1\|WP_003022248.1\|1467230_1467749_-\|DUF2892-domain-containing-protein	unknown	unknown	gnl\|CDD\|223680
NC_017450.1\|WP_014550086.1\|1461170_1461596_-\|transcription-antitermination-factor-NusB	unknown	unknown	gnl\|CDD\|273891
NC_017450.1\|WP_003018167.1\|1467814_1468114_-\|helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NC_017450.1\|WP_003037275.1\|1477285_1478176_-\|NAD(+)-kinase	unknown	unknown	gnl\|CDD\|179257
NC_017450.1\|WP_014550095.1\|1470658_1474561_-\|type-V-CRISPR-associated-protein-Cas12a/Cpf1	cas12a	cas12a_cpf1_CAS-V-A	gnl\|CDD\|275131

Protein	Function_ID	Function_description	E-value
NC_017450.1\|WP_080558946.1\|1465514_1467209_-\|SidA/IucD/PvdA-family-monooxygenase	gnl\|CDD\|163244	TIGR03385, Coenzyme_A_disulfide_reductase, CoA-disulfide reductase. Members of this protein family are CoA-disulfide reductase (EC 1.8.1.14), as characterized in Staphylococcus aureus, Pyrococcus horikoshii, and Borrelia burgdorferi, and inferred in several other species on the basis of high levels of CoA and an absence of glutathione as a protective thiol. [Cellular processes, Detoxification].	4.75864e-139
NC_017450.1\|WP_080558969.1\|1469996_1470533_-\|type-V-CRISPR-associated-protein-Cas4	gnl\|CDD\|213941	TIGR04328, hypothetical_protein_HMPREF9709_01098, CRISPR-associated protein Cas4, subtype PREFRAN. Members of this family are the Cas4 protein of a novel CRISPR subtype, PREFRAN, found in Prevotella bryantii B14, Prevotella disiens FB035-09AN, Francisella tularensis subsp. novicida, Francisella philomiragia, Butyrivibrio proteoclasticus B316, Helcococcus kunzii ATCC 51366, etc.	1.91061e-102
NC_017450.1\|WP_014550096.1\|1474648_1475164_-\|N-acetyltransferase	gnl\|CDD\|225695	COG3153, COG3153, Predicted acetyltransferase [General function prediction only].	1.21362e-39
NC_017450.1\|WP_014550098.1\|1475894_1476584_-\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	gnl\|CDD\|234649	PRK00121, trmB, tRNA (guanine-N(7)-)-methyltransferase; Reviewed.	1.72049e-87
NC_017450.1\|WP_003037275.1\|1477285_1478176_-\|NAD(+)-kinase	gnl\|CDD\|179257	PRK01231, ppnK, NAD(+) kinase.	2.47435e-91
NC_017450.1\|WP_003034662.1\|1478366_1479311_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|133030	cd04187, DPM1_like_bac, Bacterial DPM1_like enzymes are related to eukaryotic DPM1. A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.	8.89577e-82
NC_017450.1\|WP_043024573.1\|1462933_1463380_+\|YcgN-family-cysteine-cluster-protein	gnl\|CDD\|235356	PRK05170, PRK05170, YcgN family cysteine cluster protein.	3.76024e-69
NC_017450.1\|WP_043024574.1\|1476653_1477289_+\|LysE-family-translocator	gnl\|CDD\|224199	COG1280, RhtB, Putative threonine efflux protein [Amino acid transport and metabolism].	5.64978e-21
NC_017450.1\|WP_014550093.1\|1468988_1469993_-\|type-V-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|213942	TIGR04329, hypothetical_protein_SbacW_07302_partial, CRISPR-associated endonuclease Cas1, subtype PREFRAN. Members of this family are the Cas1 endonuclease of a novel CRISPR subtype, PREFRAN, found in Prevotella bryantii B14, Prevotella disiens FB035-09AN, Francisella tularensis subsp. novicida, Francisella philomiragia, Butyrivibrio proteoclasticus B316, Helcococcus kunzii ATCC 51366, etc.	0
NC_017450.1\|WP_003015040.1\|1464783_1465470_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293810	cd07724, POD-like_MBL-fold, ETHE1 (PDO type I), persulfide dioxygenase A (PDOA, PDO type II) and related proteins; MBL-fold metallo-hydrolase domain. Persulfide dioxygenase (PDO, also known as sulfur dioxygenase, SDO, EC 1.13.11.18) is a non-heme iron-dependent oxygenase which catalyzes the oxidation of glutathione persulfide to glutathione and persulfite in the mitochondria. Mutations in ethe1 (the human PDO gene) are responsible for a rare autosomal recessive metabolic disorder called ethylmalonic encephalopathy. Arabidopsis thaliana ETHE1 is essential for embryo and endosperm development. Bacterial ETHE1-type PDOs are also called Type 1 PDOs. Type II PDOs (also called PDOAs), are mainly proteobacterial. These enzymes belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	3.1463e-85
NC_017450.1\|WP_014550092.1\|1468735_1469008_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	4.95236e-13
NC_017450.1\|WP_014550090.1\|1464032_1464782_-\|sulfite-exporter-TauE/SafE-family-protein	gnl\|CDD\|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	2.79023e-31
NC_017450.1\|WP_003022248.1\|1467230_1467749_-\|DUF2892-domain-containing-protein	gnl\|CDD\|223680	COG0607, PspE, Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism].	3.87907e-19
NC_017450.1\|WP_014550086.1\|1461170_1461596_-\|transcription-antitermination-factor-NusB	gnl\|CDD\|273891	TIGR01951, nusB, transcription antitermination factor NusB. A transcription antitermination complex active in many bacteria was designated N-utilization substance (Nus) in E. coli because of its interaction with phage lambda protein N. This model represents NusB. Other components are NusA and NusG. NusE is, in fact, ribosomal protein S10. [Transcription, Transcription factors].	2.22038e-38
NC_017450.1\|WP_003018167.1\|1467814_1468114_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	3.12712e-19
NC_017450.1\|WP_080558945.1\|1463419_1464040_+\|2OG-Fe(II)-oxygenase	gnl\|CDD\|379309	pfam13640, 2OG-FeII_Oxy_3, 2OG-Fe(II) oxygenase superfamily. This family contains members of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily.	1.29174e-23
NC_017450.1\|WP_014550095.1\|1470658_1474561_-\|type-V-CRISPR-associated-protein-Cas12a/Cpf1	gnl\|CDD\|275131	TIGR04330, conserved_hypothetical_protein, CRISPR-associated protein Cpf1, subtype PREFRAN. This family is the long protein of a novel CRISPR subtype, PREFRAN, which is most common in Prevotella and Francisella, although widely distributed. The PREFRAN type has Cas1, Cas2, and Cas4, but lacks the helicase Cas3 and endonuclease Cas3-HD.	0

>NC_017450.1|WP_003018167.1|1467814_1468114_-|helix-turn-helix-transcriptional-regulator
MDLMQMKDNASKASSLLKAISHESRLLILCLLLRREMTVGELAEYSSLSQSAFSQHLSVLRNNGLVKCRKEAQNVYYSINDPSVTKILEALYSIYCGDK
>NC_017450.1|WP_003022248.1|1467230_1467749_-|DUF2892-domain-containing-protein
MNKVEKISVKQFLDLQKKEKVKLIDIRTPAEHSRECIDCAENILVDDIYDADIKPDEVVVLHCQSGNRTNQAASKVSGLNAKKVYLLDGGINAWKQHKQPTQKNVKEPLPIMRQVQIIVGFLVLLGVVLSFTVSQYFAILSGFFGAGLLFAGLTGTCGLAVMLEFLPYNRKK
>NC_017450.1|WP_080558946.1|1465514_1467209_-|SidA/IucD/PvdA-family-monooxygenase
MMTKKYLIVGGVAAGASAAARLRRLDDSAEIIMFEKGPHVSFSNCGLPYHLGGYIEPAEKLILMTPEKFDKQYNIDARTNSEVIAIDRINKLVTVINHHSGDKYSESYDKLILAVGAKPIVPPFKGLETIEHFILRNVVDVKKIHQAVFDKQKSVKDITVIGAGFIGVEVAENLKERGFNVTIIEMANQIMRPFDYEMAKFLEKELLDNGVNLLLGEKVVGFESDKVLLESGKEIKTDLAILAIGVAPDTNFLKEVGIDLAKTGHILVNDNYQTSDENIYAAGDAILVKNALTAQDFNLPLAGPANKQGRLIADHINGHKVVNKGYIGSSIIQIFNYTGAATGLNEAWIKFHNLDIDYEVAYTAPFDRVSIMPNAVNVFTKILFEKNTGKLLGAQVIGRGIVDKRADVFATAIKAGMTVEDLQDLELCYAPPYSTGKDIVNHTGYVASNLLKGDFKQVAFTKVEELLAQNAQIIDVREIGETRRGMLTNAKNIPLSEIRTRLAEIDKNQPVYVHCQTGQRSYNVVLMLQQHGYDAYNIAGGYIMISHYYDTIVHMTGKKISFTR
>NC_017450.1|WP_003015040.1|1464783_1465470_-|MBL-fold-metallo-hydrolase
MIFRQLIDRDTYTYTYILACEQTRQAVIIDSVRFNVNQYLKLLKELDLKLIYAIDTHVHADHVTAAGILRKETGCDIVIGGESKAECATKKVFDGDILEFGNYQLKALYTPGHTDDSYCFITENMLFTGDTLLIRGSGRTDFQNGDSYAAYDSIMNKLMTLPGSTIIYPGHDYNGITSSSVAEERQNNPRLKVKSPDEYAKLMADLKLPPPNYIDIAVPANLKCGIEE
>NC_017450.1|WP_014550090.1|1464032_1464782_-|sulfite-exporter-TauE/SafE-family-protein
MFLIIFGFICGIALGLTGGGGSILAVPLLTYGVGLEFHSAVMISLLVVGFTAIFGLIVNYKQRDIDYIAAVIMIITGVIFAPIGSYISQGLSDKLLMLSFSILMILIGVWSLVKVKLMSGSEKSIYKNITPRFIVALLISGGIVGTLTGFFGVGGGFLIVPALVFITAMPIKRAINTSLLVIFVVSISGFISHYDKTSMNWYIASMFIVGGAIGMFLATRVKKSLNDKVLQTIFAIMLVILGVVIYLIN
>NC_017450.1|WP_080558945.1|1463419_1464040_+|2OG-Fe(II)-oxygenase
MGIIMSDLIAINPFYEKIINDYLNKDFCIIDNWLTTDETDKLRQQLEELYQANYFKKSAVGNRLNENLERSIRSDFIFWLDETKYAQVFFEKINSFIEYINKTCFAGIVTKEFHYAVYPQGSFYKKHIDTFQNDDRRTISVVCYLNQDWQDCFGGQLKLYFKDQTLEVFPTDGKIVLFDSKSIEHEVLPVLTENKRLSITGWLKTN
>NC_017450.1|WP_043024573.1|1462933_1463380_+|YcgN-family-cysteine-cluster-protein
MSKWWQQIDLKDMSSEQWESICDRCGLCCLNKLQDDETDEVYYTRVSCKLLDIGKCQCSMYQKRKQLVPECVNLTYKQLKNHAHKWLPSSCSYKLLFEGKDLPDWHHLNTGSTEEMHKQKKSAKHFAISEYELDVDEYLEDFIIKIDN
>NC_017450.1|WP_080558968.1|1462245_1462713_+|hypothetical-protein
MSGCASSGPQQPNLTPLQIQLMQTKVFNVDLRTAFDATVTVMQNLGYIIQDANFNSGIITAKSTQTANFWGDSEYTEATAFIQTYRQSNKNSSIRINFVVYNSMPNPNQGGTPINTSSAILDPQAYENAFAKIQQQIFVQTGISPVLTQPIQQVS
>NC_017450.1|WP_003025316.1|1461782_1462184_+|hypothetical-protein
MKFNIICMLGLAFILSSCVSNTNPENVGFVKTPYTSGNVSLTLKKGVTTKDQVINAFGSPNIVTQNADGESVWTYQTNATVENNAARDGFLTLLITGENTEESGFMQSQKTMTIIITFKGNVVSDYKSLSTNF
>NC_017450.1|WP_014550086.1|1461170_1461596_-|transcription-antitermination-factor-NusB
MKTTARARNNARLYAVQALYQKKIADNTFSELKVQYYADNADRHYTDWDLFYRLIDAVKTNQDTIDKYIKENSSNGVESINYVDYAVLQVAIAELIECLENPYQVIIKEYVEICYSMGTEEGYKFINAVLQNLAKSIRGEE
>NC_017450.1|WP_014550092.1|1468735_1469008_-|CRISPR-associated-endonuclease-Cas2
MLIVSYDFSNNKVRAKFAKFLESYGVRLQYSVFELKYSKRMLDLILAEIENHYVPLFTNADSVLIFNAPDKDVIKYGYAIHREQEVVFID
>NC_017450.1|WP_014550093.1|1468988_1469993_-|type-V-CRISPR-associated-endonuclease-Cas1
MFSKNDIESKNIVFINIFDGVKLSLSLGNIVIKDKETDEVKTKLSVHKVLVLFIVGNMTMTSQLLETCKKNAIQLVFMKNSFRPYLCFGDIAEANFLARYKQYSVVEQDISLARIFITSKIRNQHNLVKSLRDKTPEQQEIVKKNKQLIAELENTTSLAELMGIEGNVAKNFFKGFYGHLDSWQGRKPRIKQDPYNVVLDLGYSMLFNFVECFLRLFGFDLYKGFCHQTWYKRKSLVCDFVEPFRCIVDNQVRKSWNLGQFSVEDFGCKNEQFYIKKDKTKDYSKILFAEIISYKLEIFEYVREFYRAFMRGKEIAEYPIFCYETRRVYVDSQL
>NC_017450.1|WP_080558969.1|1469996_1470533_-|type-V-CRISPR-associated-protein-Cas4
MTWLNDFIFCPYSIYLHNIYSNASDTTYYSSSQTKGRDAHKSIDKGIYSTKKDDLIGIDVINHKYGLVGKIDVFHKDKGLLVERKRQIKTIYDGYKYQLYAQYFCLLEMGYDVKAIKFYSMVDNKSYPIAIPTSAELEKFEKHIQTIKQYNPMDNSFRQNIEKCKFCIYANLCDKTDL
>NC_017450.1|WP_014550095.1|1470658_1474561_-|type-V-CRISPR-associated-protein-Cas12a/Cpf1
MSIYQEFVNKYSLSKTLRFELIPQGKTLENIKARGLILDDEKRAKDYKKAKQIIDKYHQFFIEEILSSVCISEDLLQNYSDVYFKLKKSDDDNLQKDFKSAKDTIKKQISEYIKDSEKFKNLFNQNLIDAKKGQESDLILWLKQSKDNGIELFKANSDITDIDEALEIIKSFKGWTTYFKGFHENRKNVYSSNDIPTSIIYRIVDDNLPKFLENKAKYESLKDKAPEAINYEQIKKDLAEELTFDIDYKTSEVNQRVFSLDEVFEIANFNNYLNQSGITKFNTIIGGKFVNGENTKRKGINEYINLYSQQINDKTLKKYKMSVLFKQILSDTESKSFVIDKLEDDSDVVTTMQSFYEQIAAFKTVEEKSIKETLSLLFDDLKAQKLDLSKIYFKNDKSLTDLSQQVFDDYSVIGTAVLEYITQQVAPKNLDNPSKKEQDLIAKKTEKAKYLSLETIKLALEEFNKHRDIDKQCRFEEILANFAAIPMIFDEIAQNKDNLAQISIKYQNQGKKDLLQASAEDDVKAIKDLLDQTNNLLHRLKIFHISQSEDKANILDKDEHFYLVFEECYFELANIVPLYNKIRNYITQKPYSDEKFKLNFENSTLANGWDKNKEPDNTAILFIKDDKYYLGVMNKKNNKIFDDKAIKENKGEGYKKIVYKLLPGANKMLPKVFFSAKSIKFYNPSEDILRIRNHSTHTKNGNPQKGYEKFEFNIEDCRKFIDFYKESISKHPEWKDFGFRFSDTQRYNSIDEFYREVENQGYKLTFENISESYIDSVVNQGKLYLFQIYNKDFSAYSKGRPNLHTLYWKALFDERNLQDVVYKLNGEAELFYRKKSIPKKITHPAKEAIANKNKDNPKKESFFEYDLIKDKRFTEDKFFFHCPITINFKSSGANKFNDEINLLLKEKANDVHILSIDRGERHLAYYTLVDGKGNIIKQDTFNIIGNDRMKTNYHDKLAAIEKDRDSARKDWKKINNIKEMKEGYLSQVVHEIAKLVIEHNAIVVFEDLNFGFKRGRFKVEKQVYQKLEKMLIEKLNYLVFKDNEFDKTGGVLRAYQLTAPFETFKKMGKQTGIIYYVPAGFTSKICPVTGFVNQLYPKYESVSKSQEFFSKFDKICYNLDKGYFEFSFDYKNFGDKAAKGKWTIASFGSRLINFRNSDKNHNWDTREVYPTKELEKLLKDYSIEYGHGECIKAAICGESDKKFFAKLTSILNTILQMRNSKTGTELDYLISPVADVNGNFFDSRQAPKNMPQDADANGAYHIGLKGLMLLDRIKNNQEGKKLNLVIKNEEYFEFVQNRNN
>NC_017450.1|WP_014550096.1|1474648_1475164_-|N-acetyltransferase
MHVKIRYEKLKDQELIYKLISEAFDTGDEEKLVRLLHTDHQSLISLVAETDDSSIIGQAIISKMTAEKDQTLKIYALAPMSVAPKYQHQGIGSKLIEAMIKEAKKNNIDAIFVLGHPSYYPKFGFKPATEYQIKCEYDVPADVFMVLDLSAKLASLKGQTVYYAEEFGKIF
>NC_017450.1|WP_014550097.1|1475168_1475885_-|hypothetical-protein
MKIARYKKGFIKASEYNSKLHFDNIFCPDCGKAKVKIVRKADQEPYFVFVQDQQHDELCPRVAKPIQDQKIKELILSDSKKDMSKLNFLVNKNLEKCINLVTKLENNGELKKADELNLMPQKKQQITEKRIREYAKQDIHTINIVDLSDIDTQQLNNKYCLIYGVAGITLADVGDSKKLFFKADQDSRFSLFVVPSQIKYLDFDKGKRTKFAVFGRFKKVGKFINLEIRSTRDLVIRD
>NC_017450.1|WP_014550098.1|1475894_1476584_-|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB
MCDKSKENLRQIKSYVQRAGRVTKKQQQALDNYAAKYLIEYAKDRKLDFTEIFANTNDVVLEIGFGMGGSLVEMALANPAKNYLGIEVHKAGVGNILYEIEHQNIANLVVMSHDAVEILENMIADKSLASIQVYFPDPWHKKKHNKRRLVNQTNIDLFAKKLKVGGVFHYASDWLPYAEEVLELLENDSKYRNLYSGFAPRPEWRPLTKFEKRGQNLDHPISDILFEKV
>NC_017450.1|WP_043024574.1|1476653_1477289_+|LysE-family-translocator
MLIFLTILALQISCLILPGPDFFVTISNSIKFGHKSGIYTASGVASGIFLNTFIVYWFGSFLLYKQPLLFKMLIIIGAAYLAYIAFSLYKSIFTKQQLNPNANQHIKNLDNFDKPSNIKFFLNGAFTNLANAKVLVFFSSMLSLVDELNSFGKVAIWIAIALTTLVWFCIVATFFGNDKLRQVFFRNIKKIEFISAIFITIFVIVILVELF
>NC_017450.1|WP_003037275.1|1477285_1478176_-|NAD(+)-kinase
MAFKYHKVAIIGKHYKKEVSQMVETLYAYLQQQGLEIIIENDTAADTSLVNVAIASLKEIALRCDVAIVVGGDGNFLKASRLLALYSNIPVIGINKGKLGFLTTLAADDNALKNDLYAILKGDSSVTKMSMLKCRVDNNLRAPLEASIALNEIAITASRGLMFGLKVFIDGRYAFDQRGDGLIVSTPTGSTAHAMSAGGPILNPNQNSVVLVPICSHSLNSRPLVISDESVIDIYITDYNDPEPVLSIDGRHDTILKAHQKVTIQKARKKVTVLHTKDYNYYDTLREKLGWSKVLF
>NC_017450.1|WP_003034662.1|1478366_1479311_+|glycosyltransferase-family-2-protein
MDNKDKLTSIIIPVKDEAEGIEHLFARLMPILKKLPTKYELVFINDGSNDNTLELLLEKQKDIPEIAIVDLSRNFGKEAALFAGFANCNGDAAISIDADLQDPPELILEMVQHWLDGYEVVTAVRENRDTDTSTKKHTAGLFYKVMNKISDTKLTPNAGDYRLLNRAAVNAFLELKEKIRFNKGLLTWIGFKEKIVYHAREERAAGQTKWNYWKLFKFSIDGITSFSRAPLEIWSYIGVVVALISFIYGSIIVLKSLLFGVDVPGYPSLVTFILFFSGLQMIGIGMLGSYIGRIFIETKHRPLYIIRQVHRAKE

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_017450_2	2.6\|1468533\|28\|NC_017450\|CRISPRCasFinder,CRT,PILER-CR	1468533-1468560	28	MG945522	UNVERIFIED: Microviridae sp. isolate 2039-1602, complete genome	4801-4828	6	0.786
NC_017450_2	2.5\|1468469\|28\|NC_017450\|CRISPRCasFinder,CRT,PILER-CR	1468469-1468496	28	NC_014633	Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequence	867162-867189	8	0.714

1. spacer 2.6|1468533|28|NC_017450|CRISPRCasFinder,CRT,PILER-CR matches to MG945522 (UNVERIFIED: Microviridae sp. isolate 2039-1602, complete genome) position: , mismatch: 6, identity: 0.786

tttggagtggttattatgaagagatggc	CRISPR spacer
ttgaaggtggttattatgaagagatgat	Protospacer
** ...********************..

2. spacer 2.5|1468469|28|NC_017450|CRISPRCasFinder,CRT,PILER-CR matches to NC_014633 (Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequence) position: , mismatch: 8, identity: 0.714

ttggaagaatatgccagtccatatgtta	CRISPR spacer
actgaagaatttgccagtccatatcaag	Protospacer
 . ******* *************   .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

95863 : 105322

Staphylococcus_phage(42.86%)

tRNA

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014549197.1\|95863_97648_+	elongation factor 4	A0A2K9L6L3	Tupanvirus	4.2e-23	42.6
WP_080558888.1\|97595_98741_+\|tRNA	tRNA 2-thiouridine(34) synthase MnmA	NA	NA	NA	NA
WP_080558889.1\|98760_99753_-	hypothetical protein	NA	NA	NA	NA
WP_080558890.1\|99836_100361_-	peptide deformylase	A0A067XQZ3	Caulobacter_phage	1.2e-15	37.5
WP_014549201.1\|100357_100801_-	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	2.2e-26	46.4
WP_014549202.1\|100810_102022_-	3,4-dihydroxy-2-butanone-4-phosphate synthase	A0A2H4PQS2	Staphylococcus_phage	6.2e-87	44.3
WP_003022624.1\|102014_102620_-	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	2.7e-27	35.1
WP_014549203.1\|102612_103680_-	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A1V0SE20	Indivirus	1.8e-50	36.0
WP_014549204.1\|104071_105322_+	sodium:proton antiporter	A0A2H4J178	uncultured_Caudovirales_phage	1.6e-29	34.3

DBSCAN-SWA_2

385947 : 395446

Enterococcus_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014549389.1\|385947_386796_+	bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase	A0A249XZQ2	Enterococcus_phage	1.1e-29	38.8
WP_003033096.1\|386958_387249_+	GIY-YIG nuclease family protein	NA	NA	NA	NA
WP_014549390.1\|387365_388409_+	phosphoribosylformylglycinamidine cyclo-ligase	A0A1D7SQF5	Cyanophage	5.4e-55	36.6
WP_014549391.1\|388408_390721_+	phosphoribosylamine--glycine ligase	A0A0M4JBD3	Mollivirus	1.2e-25	30.4
WP_014549392.1\|390724_391300_+	phosphoribosylglycinamide formyltransferase	Q58MV3	Prochlorococcus_phage	1.7e-18	34.7
WP_014549393.1\|391416_391908_+	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	5.9e-20	40.1
WP_014549394.1\|391911_393009_+	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
WP_003026519.1\|393005_393359_-	YraN family protein	NA	NA	NA	NA
WP_014549395.1\|393439_395446_-	M3 family metallopeptidase	A0A1V0SID3	Klosneuvirus	2.4e-51	25.9

DBSCAN-SWA_3

1031627 : 1039947

Alteromonas_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014549835.1\|1031627_1033400_+	ribonucleoside-diphosphate reductase subunit alpha	R4W390	Alteromonas_phage	5.2e-183	57.4
WP_003018894.1\|1033403_1033664_+	glutaredoxin	A0A2L0UZP1	Agrobacterium_phage	6.9e-12	42.7
WP_003033975.1\|1033670_1034903_+	ribonucleotide-diphosphate reductase subunit beta	Q678G9	Lymphocystis_disease_virus	6.9e-102	53.6
WP_014549836.1\|1034899_1036792_-	ATP-binding cassette domain-containing protein	A0A2K9L0W2	Tupanvirus	9.1e-69	33.4
WP_014549837.1\|1036904_1037507_+	DJ-1/PfpI family protein	NA	NA	NA	NA
WP_014549838.1\|1037503_1038556_+	DNA polymerase IV	F1C5A5	Cronobacter_phage	1.3e-08	22.3
WP_014549839.1\|1038895_1039480_-	DUF4145 domain-containing protein	NA	NA	NA	NA
WP_014549840.1\|1039737_1039947_-	hypothetical protein	Q9JMN3	Wolbachia_phage	6.6e-05	45.8

DBSCAN-SWA_4

1051054 : 1114628

Tupanvirus(18.18%)

protease,tRNA,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003015772.1\|1051054_1051606_+\|protease	ATP-dependent protease subunit HslV	NA	NA	NA	NA
WP_014549847.1\|1051613_1052981_+\|protease	ATP-dependent protease ATPase subunit HslU	A0A2H5BJT2	Erwinia_phage	2.1e-46	29.5
WP_003034008.1\|1055872_1057288_+	Si-specific NAD(P)(+) transhydrogenase	NA	NA	NA	NA
WP_014549852.1\|1057291_1058140_+	prepilin peptidase	NA	NA	NA	NA
WP_014549853.1\|1058149_1058995_+	DsbC family protein	NA	NA	NA	NA
WP_003036663.1\|1059003_1059888_+	class A beta-lactamase	A0A1B0VBP7	Salmonella_phage	7.0e-40	35.0
WP_014549854.1\|1059880_1060456_+\|tRNA	aminoacyl-tRNA hydrolase	NA	NA	NA	NA
WP_014549855.1\|1060474_1061566_+	redox-regulated ATPase YchF	NA	NA	NA	NA
WP_003036665.1\|1061580_1061859_+	hypothetical protein	NA	NA	NA	NA
WP_014549856.1\|1061895_1063155_-	DUF21 domain-containing protein	NA	NA	NA	NA
WP_003018840.1\|1063250_1063541_-	50S ribosomal protein L25	NA	NA	NA	NA
WP_003015739.1\|1063640_1064609_-	ribose-phosphate pyrophosphokinase	A0A2K9L8D8	Tupanvirus	9.1e-41	35.3
WP_003039457.1\|1064819_1065827_+	succinylglutamate desuccinylase/aspartoacylase family protein	NA	NA	NA	NA
WP_003036670.1\|1065819_1067103_+	MFS transporter	NA	NA	NA	NA
WP_003036671.1\|1067109_1068396_-	MFS transporter	NA	NA	NA	NA
WP_014549859.1\|1068688_1069522_+	mechanosensitive ion channel	NA	NA	NA	NA
WP_014549860.1\|1069505_1070675_-	cation:proton antiporter	NA	NA	NA	NA
WP_014549861.1\|1070772_1071405_-	nicotinamide mononucleotide transporter	A0A2I7SAC7	Vibrio_phage	1.1e-07	23.3
WP_014549862.1\|1071404_1071908_-	isochorismatase family protein	NA	NA	NA	NA
WP_003036682.1\|1072013_1072517_-	isochorismatase family protein	NA	NA	NA	NA
WP_003018833.1\|1072644_1073226_+	DNA-3-methyladenine glycosylase	NA	NA	NA	NA
WP_014549865.1\|1073316_1074015_+	hypothetical protein	NA	NA	NA	NA
WP_014549866.1\|1074029_1075166_+	histidine decarboxylase	NA	NA	NA	NA
WP_003034054.1\|1075152_1075965_-	amidohydrolase family protein	NA	NA	NA	NA
WP_003034056.1\|1076129_1076591_+	hypothetical protein	M4QRU0	Micromonas_pusilla_virus	2.6e-22	39.9
WP_003015717.1\|1076626_1076923_+	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_003036691.1\|1076944_1077532_-	membrane protein	NA	NA	NA	NA
WP_003039499.1\|1077580_1078996_-	DNA recombination protein RmuC	NA	NA	NA	NA
WP_076730795.1\|1079021_1079675_-	Holliday junction branch migration protein RuvA	NA	NA	NA	NA
WP_014549867.1\|1079684_1080878_-	MFS transporter	NA	NA	NA	NA
WP_003026245.1\|1080959_1081475_-	crossover junction endodeoxyribonuclease RuvC	NA	NA	NA	NA
WP_003034072.1\|1081571_1082318_-	YebC/PmpR family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_014549868.1\|1082333_1082993_-	isoprenoid biosynthesis glyoxalase ElbB	NA	NA	NA	NA
WP_003018819.1\|1083022_1084006_-	lipoyl synthase	NA	NA	NA	NA
WP_003034079.1\|1084212_1084713_+	ferritin	NA	NA	NA	NA
WP_043024554.1\|1086358_1087003_+	glutaredoxin 2	NA	NA	NA	NA
WP_003036701.1\|1087004_1087634_+	RnfABCDGE type electron transport complex subunit B	NA	NA	NA	NA
WP_014549873.1\|1087626_1088265_+	endonuclease III	NA	NA	NA	NA
WP_003020393.1\|1088261_1088693_+	DUF1841 family protein	NA	NA	NA	NA
WP_003039524.1\|1088692_1089952_+	hypothetical protein	NA	NA	NA	NA
WP_003018803.1\|1090067_1090754_+	Bax inhibitor-1/YccA family protein	A0A2H4JFM9	uncultured_Caudovirales_phage	4.6e-31	42.3
WP_014549874.1\|1090798_1094224_+	transcription-repair coupling factor	NA	NA	NA	NA
WP_014549875.1\|1094346_1095390_-	ketol-acid reductoisomerase	NA	NA	NA	NA
WP_003015556.1\|1095417_1095735_-	acetolactate synthase small subunit	NA	NA	NA	NA
WP_014549876.1\|1095739_1097437_-	biosynthetic-type acetolactate synthase large subunit	A0A0P0CDR3	Ostreococcus_lucimarinus_virus	1.0e-58	30.4
WP_014549877.1\|1097628_1098279_+\|transposase	IS1595 family transposase	NA	NA	NA	NA
WP_014549878.1\|1098302_1099985_-	dihydroxy-acid dehydratase	NA	NA	NA	NA
WP_003034109.1\|1100009_1101806_-	threonine synthase	NA	NA	NA	NA
WP_003015672.1\|1101948_1102542_-	YihA family ribosome biogenesis GTP-binding protein	NA	NA	NA	NA
WP_014549880.1\|1102538_1103024_-	low molecular weight phosphotyrosine protein phosphatase	NA	NA	NA	NA
WP_003018795.1\|1103024_1103951_-\|protease	protease modulator HflC	A0A2K9KZA2	Tupanvirus	7.5e-08	21.9
WP_003018791.1\|1103952_1105020_-\|protease	FtsH protease activity modulator HflK	NA	NA	NA	NA
WP_014549881.1\|1105204_1106383_+	FAD-binding domain	NA	NA	NA	NA
WP_003036725.1\|1106393_1107701_-	GTPase HflX	NA	NA	NA	NA
WP_003015654.1\|1107753_1108083_-	RNA chaperone Hfq	NA	NA	NA	NA
WP_003036727.1\|1108193_1109120_-\|tRNA	tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA	NA	NA	NA	NA
WP_014549882.1\|1109120_1110554_-	hypothetical protein	NA	NA	NA	NA
WP_003034128.1\|1110666_1110939_-	HU family DNA-binding protein	Q6QIE5	Burkholderia_phage	6.5e-21	58.9
WP_014549883.1\|1111025_1113350_-	endopeptidase La	A0A0R6PGP8	Moraxella_phage	6.1e-192	47.2
WP_003036795.1\|1113374_1114628_-\|protease	ATP-dependent Clp protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	1.1e-126	56.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_017450

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection