CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_003210	Listeria monocytogenes EGD-e chromosome, complete genome	5 crisprs	DinG,cas3,WYL,casR,csa3,DEDDh	0	2	5	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_003210_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_003210_1

210313-210464

Unclear

Consensus_repeat	Method
CCAATGCTTCTTGGTTTTAATGCTCCTGCTACATCAGAACCGAGCTC	CRISPRCasFinder

1 spacers

cas3

The CRISPR arrays of NC_003210_1

>merge|NC_003210|1|210313-210464|CRISPRCasFinder
CCAATGCTTCTTGGTTTTAATGCTCCTGCTACATCAGAACCGAGCTCATTCGAATTTCCACCACCACCTACGGATGAAGAGTTAAGACTTGCTTTGCCAGAGACGCCAATGCTTCTTGGTTTTAATGCTCCTGCTACATCGGAACCGAGCTC

>NC_003210|1|1|210313-210464|CRISPRCasFinder
CCAATGCTTCTTGGTTTTAATGCTCCTGCTACATCAGAACCGAGCTC	ATTCGAATTTCCACCACCACCTACGGATGAAGAGTTAAGACTTGCTTTGCCAGAGACG
CCAATGCTTCTTGGTTTTAATGCTCCTGCTACATCGGAACCGAGCTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_003210.1\|NP_463730.1\|202640_203597_+\|ribose-phosphate-pyrophosphokinase	unknown	unknown	gnl\|CDD\|234929
NC_003210.1\|NP_463744.1\|217124_217685_+\|peptidyl-tRNA-hydrolase	unknown	unknown	gnl\|CDD\|235457
NC_003210.1\|NP_463743.1\|216433_217018_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379228
NC_003210.1\|NP_463731.1\|203639_204353_-\|listeriolysin-positive-regulatory-protein	unknown	unknown	gnl\|CDD\|223736
NC_003210.1\|NP_463738.1\|212823_213285_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227145
NC_003210.1\|NP_463739.1\|213335_213668_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|179228
NC_003210.1\|NP_463727.1\|200093_200402_+\|regulatory-protein-SpoVG	unknown	unknown	gnl\|CDD\|237321
NC_003210.1\|NP_463745.1\|217799_221339_+\|transcription-repair-coupling-factor	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|224118
NC_003210.1\|NP_463742.1\|215720_216344_+\|50S-ribosomal-protein-L25	unknown	unknown	gnl\|CDD\|235534
NC_003210.1\|NP_463733.1\|205818_207408_+\|listeriolysin-O-precursor	unknown	unknown	gnl\|CDD\|366559
NC_003210.1\|NP_463736.1\|211424_212294_+\|phospholipase-C	unknown	unknown	gnl\|CDD\|214813
NC_003210.1\|NP_463725.1\|197511_198204_+\|ABC-transporter,-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NC_003210.1\|NP_463741.1\|214485_215427_-\|L-lactate-dehydrogenase	unknown	unknown	gnl\|CDD\|178836
NC_003210.1\|NP_463728.1\|200521_200830_+\|regulatory-protein-SpoVG	unknown	unknown	gnl\|CDD\|237321
NC_003210.1\|NP_463734.1\|207738_209271_+\|Zinc-metalloproteinase-precursor	unknown	unknown	gnl\|CDD\|225768
NC_003210.1\|NP_463729.1\|201216_202590_+\|bifunctional-N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase	unknown	unknown	gnl\|CDD\|184643
NC_003210.1\|NP_463740.1\|213734_214409_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378033
NC_003210.1\|NP_463732.1\|204623_205577_-\|phosphatidylinositol-specific-phospholipase-c	unknown	unknown	gnl\|CDD\|176497
NC_003210.1\|NP_463726.1\|198200_199409_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|182528
NC_003210.1\|NP_463737.1\|212365_212689_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|340321

Protein	Function_ID	Function_description	E-value
NC_003210.1\|NP_463730.1\|202640_203597_+\|ribose-phosphate-pyrophosphokinase	gnl\|CDD\|234929	PRK01259, PRK01259, ribose-phosphate diphosphokinase.	0
NC_003210.1\|NP_463744.1\|217124_217685_+\|peptidyl-tRNA-hydrolase	gnl\|CDD\|235457	PRK05426, PRK05426, peptidyl-tRNA hydrolase; Provisional.	4.98809e-109
NC_003210.1\|NP_463743.1\|216433_217018_+\|hypothetical-protein	gnl\|CDD\|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	7.52035e-10
NC_003210.1\|NP_463731.1\|203639_204353_-\|listeriolysin-positive-regulatory-protein	gnl\|CDD\|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	9.59942e-12
NC_003210.1\|NP_463738.1\|212823_213285_+\|hypothetical-protein	gnl\|CDD\|227145	COG4808, COG4808, Uncharacterized protein conserved in bacteria [Function unknown].	5.22035e-59
NC_003210.1\|NP_463739.1\|213335_213668_-\|hypothetical-protein	gnl\|CDD\|179228	PRK01119, PRK01119, putative heavy metal-binding protein.	8.98192e-61
NC_003210.1\|NP_463727.1\|200093_200402_+\|regulatory-protein-SpoVG	gnl\|CDD\|237321	PRK13259, PRK13259, septation regulator SpoVG.	2.92652e-53
NC_003210.1\|NP_463745.1\|217799_221339_+\|transcription-repair-coupling-factor	gnl\|CDD\|224118	COG1197, Mfd, Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription].	0
NC_003210.1\|NP_463742.1\|215720_216344_+\|50S-ribosomal-protein-L25	gnl\|CDD\|235534	PRK05618, PRK05618, 50S ribosomal protein L25/general stress protein Ctc; Reviewed.	2.38585e-63
NC_003210.1\|NP_463733.1\|205818_207408_+\|listeriolysin-O-precursor	gnl\|CDD\|366559	pfam01289, Thiol_cytolysin, Thiol-activated cytolysin.	1.50399e-178
NC_003210.1\|NP_463736.1\|211424_212294_+\|phospholipase-C	gnl\|CDD\|214813	smart00770, Zn_dep_PLPC, Zinc dependent phospholipase C (alpha toxin). This domain conveys a zinc dependent phospholipase C activity (EC 3.1.4.3). It is found in a monomeric phospholipase C of Bacillus cereus as well as in the alpha toxin of Clostridium perfringens and Clostridium bifermentans, which is involved in haemolysis and cell rupture. It is also found in a lecithinase of Listeria monocytogenes, which is involved in breaking the 2-membrane vacuoles that surround the bacterium. Structure information: PDB 1ca1.	4.70099e-87
NC_003210.1\|NP_463725.1\|197511_198204_+\|ABC-transporter,-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	7.27113e-121
NC_003210.1\|NP_463741.1\|214485_215427_-\|L-lactate-dehydrogenase	gnl\|CDD\|178836	PRK00066, ldh, L-lactate dehydrogenase; Reviewed.	0
NC_003210.1\|NP_463728.1\|200521_200830_+\|regulatory-protein-SpoVG	gnl\|CDD\|237321	PRK13259, PRK13259, septation regulator SpoVG.	5.03804e-54
NC_003210.1\|NP_463734.1\|207738_209271_+\|Zinc-metalloproteinase-precursor	gnl\|CDD\|225768	COG3227, LasB, Zinc metalloprotease (elastase) [Amino acid transport and metabolism].	7.98048e-139
NC_003210.1\|NP_463729.1\|201216_202590_+\|bifunctional-N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase	gnl\|CDD\|184643	PRK14354, glmU, bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU.	0
NC_003210.1\|NP_463740.1\|213734_214409_-\|hypothetical-protein	gnl\|CDD\|378033	pfam08713, DNA_alkylation, DNA alkylation repair enzyme. Proteins in this family are predicted to be DNA alkylation repair enzymes. The structure of a hypothetical protein in this family shows it to adopt a supercoiled alpha helical structure.	1.81561e-21
NC_003210.1\|NP_463732.1\|204623_205577_-\|phosphatidylinositol-specific-phospholipase-c	gnl\|CDD\|176497	cd00137, PI-PLCc, Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C. This subfamily corresponds to the catalytic domain present in prokaryotic and eukaryotic phosphoinositide-specific phospholipase C (PI-PLC), which is a ubiquitous enzyme catalyzing the cleavage of the sn3-phosphodiester bond in the membrane phosphoinositides (phosphatidylinositol, PI; Phosphatidylinositol-4-phosphate, PIP; phosphatidylinositol 4,5-bisphosphate, PIP2) to yield inositol phosphates (inositol monosphosphate, InsP; inositol diphosphate, InsP2; inositol trisphosphate, InsP3) and diacylglycerol (DAG). The higher eukaryotic PI-PLCs (EC 3.1.4.11) have a multidomain organization that consists of a PLC catalytic core domain, and various regulatory domains. They play a critical role in most signal transduction pathways, controlling numerous cellular events, such as cell growth, proliferation, excitation and secretion. These PI-PLCs strictly require Ca2+ for their catalytic activity. They display a clear preference towards the hydrolysis of the more highly phosphorylated PI-analogues, PIP2 and PIP, to generate two important second messengers, InsP3 and DAG. InsP3 triggers inflow of calcium from intracellular stores, while DAG, together with calcium, activates protein kinase C, which then phosphorylates other molecules, leading to altered cellular activity. In contrast, bacterial PI-PLCs contain a single catalytic domain. Although their precise physiological function remains unclear, bacterial PI-PLCs may function as virulence factors in some pathogenic bacteria. They participate in Ca2+-independent PI metabolism. They are characterized as phosphatidylinositol-specific phospholipase C (EC 4.6.1.13) that selectively hydrolyze PI, not PIP or PIP2. The TIM-barrel type catalytic domain in bacterial PI-PLCs is very similar to the one in eukaryotic PI-PLCs, in which the catalytic domain is assembled from two highly conserved X- and Y-regions split by a divergent linker sequence. The catalytic mechanism of both prokaryotic and eukaryotic PI-PLCs is based on general base and acid catalysis utilizing two well conserved histidines, and consists of two steps, a phosphotransfer and a phosphodiesterase reaction. This superfamily also includes a distinctly different type of eukaryotic PLC, glycosylphosphatidylinositol-specific phospholipase C (GPI-PLC), an integral membrane protein characterized in the protozoan parasite Trypanosoma brucei. T. brucei GPI-PLC hydrolyzes the GPI-anchor on the variant specific glycoprotein (VSG), releasing dimyristyl glycerol (DMG), which may facilitate the evasion of the protozoan to the host#s immune system. It does not require Ca2+ for its activity and is more closely related to bacterial PI-PLCs, but not mammalian PI-PLCs.	8.10719e-115
NC_003210.1\|NP_463726.1\|198200_199409_+\|ABC-transporter-permease	gnl\|CDD\|182528	PRK10535, PRK10535, macrolide ABC transporter ATP-binding protein/permease MacB.	2.47504e-62
NC_003210.1\|NP_463737.1\|212365_212689_+\|hypothetical-protein	gnl\|CDD\|340321	pfam17606, DUF5502, Family of unknown function (DUF5502). This is a family of unknown function found in Listeria.	9.06348e-49

>NC_003210.1|NP_463734.1|207738_209271_+|Zinc-metalloproteinase-precursor
MKSKLICIIMVIAFQAHFTMTVKADSVGEEKLQNNTQAKKTPADLKALPDSCEAKDFYKNFKILDMTKDKLGVTHYTLALSSGGYLTDNDEIKVHVTPDNKITFINGDLQQGQLRITNQIKITEKNAIEKAFEAIGQSEAHVKSYVGNPVKEKEIILNSRTKRLVYNIKLIFAEPEVASWIVQVDVETGAILKKQNMLSEVERADTHKDFQALGKGANRLLQRPLHVMKINDLFYLVDRTHKGLIRTFDLKHNTDTSFGKVVSNKTNMFTDPEFSSAVDAHFYASEVYEYYKNVHQLESLDGKGGEIDSFVHYGLNCNNAFWDGQEILYGDGDKKNFKPFSCAKTIVGHELTHAVIQYSAGLEYEGQSGALNESFADVFGYFIAPNHWLIGEDVCVRGSRDGRIRSIKDPDKYNQAAHMKDYESLPLTEEGDWGGVHYNSGIPNKAAYNTITKLGKEKTEQLYFRALKYYLTKKSQFTDAKKALQQAAKDLYGEDASKKVAEAWEAVGVN
>NC_003210.1|NP_463733.1|205818_207408_+|listeriolysin-O-precursor
MKKIMLVFITLILVSLPIAQQTEAKDASAFNKENSISSMAPPASPPASPKTPIEKKHADEIDKYIQGLDYNKNNVLVYHGDAVTNVPPRKGYKDGNEYIVVEKKKKSINQNNADIQVVNAISSLTYPGALVKANSELVENQPDVLPVKRDSLTLSIDLPGMTNQDNKIVVKNATKSNVNNAVNTLVERWNEKYAQAYPNVSAKIDYDDEMAYSESQLIAKFGTAFKAVNNSLNVNFGAISEGKMQEEVISFKQIYYNVNVNEPTRPSRFFGKAVTKEQLQALGVNAENPPAYISSVAYGRQVYLKLSTNSHSTKVKAAFDAAVSGKSVSGDVELTNIIKNSSFKAVIYGGSAKDEVQIIDGNLGDLRDILKKGATFNRETPGVPIAYTTNFLKDNELAVIKNNSEYIETTSKAYTDGKINIDHSGGYVAQFNISWDEVNYDPEGNEIVQHKNWSENNKSKLAHFTSSIYLPGNARNINVYAKECTGLAWEWWRTVIDDRNLPLVKNRNISIWGTTLYPKYSNKVDNPIE
>NC_003210.1|NP_463732.1|204623_205577_-|phosphatidylinositol-specific-phospholipase-c
MYKNYLQRTLVLLLCFILYFFTFPLGGKAYSLNNWNKPIKNSVTTKQWMSALPDTTNLAALSIPGTHDTMSYNGDITWTLTKPLAQTQTMSLYQQLEAGIRYIDIRAKDNLNIYHGPIFLNASLSGVLETITQFLKKNPKETIIMRLKDEQNSNDSFDYRIQPLINIYKDYFYTTPRTDTSNKIPTLKDVRGKILLLSENHTKKPLVINSRKFGMQFGAPNQVIQDDYNGPSVKTKFKEIVQTAYQASKADNKLFLNHISATSLTFTPRQYAAALNNKVEQFVLNLTSEKVRGLGILIMDFPEKQTIKNIIKNNKFN
>NC_003210.1|NP_463731.1|203639_204353_-|listeriolysin-positive-regulatory-protein
MNAQAEEFKKYLETNGIKPKQFHKKELIFNQWDPQEYCIFLYDGITKLTSISENGTIMNLQYYKGAFVIMSGFIDTETSVGYYNLEVISEQATAYVIKINELKELLSKNLTHFFYVFQTLQKQVSYSLAKFNDFSINGKLGSICGQLLILTYVYGKETPDGIKITLDNLTMQELGYSSGIAHSSAVSRIISKLKQEKVIVYKNSCFYVQNLDYLKRYAPKLDEWFYLACPATWGKLN
>NC_003210.1|NP_463730.1|202640_203597_+|ribose-phosphate-pyrophosphokinase
MSNEYFDPKLKIFSLNSNRELAEEIAKEVGIELGKSSVTHFSDGEIQINIEESIRGCHVYVIQSTSNPVNQNLMELLIMIDALKRASAATINIVMPYYGYARQDRKARSREPITAKLVANLIETAGATRMITLDMHAPQIQGFFDIPIDHLNAVRLLSDYFSERHLGDDLVVVSPDHGGVTRARKMADRLKAPIAIIDKRRPRPNVAEVMNIVGNVEGKVCIIIDDIIDTAGTITLAAKALREAGATKVYACCSHPVLSGPAMKRIEESPIEKLVVTNSIALPEEKWIDKMEQLSVAALLGEAIVRVHENASVSSLFE
>NC_003210.1|NP_463729.1|201216_202590_+|bifunctional-N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase
MSKRYAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDQISTLNVDKVVTIVGHGAEKVQEHLAGKSEFVKQDEQLGTAHAVLQAKAELAGKDGVTLVVCGDTPLIEASTMEALLKYHHEKRAKATILTTVIEDPTGYGRIIRDDLGIVEKIVEHKDATEKEQRISEINTGTYCFDNKALFEALENVSNDNVQGEYYLPDVIKILKDSDEVVAAYRMESFEESLGVNDRIALAEASKLMQRRINENHMRNGVTLVNPESTYIDIDVKIGQDTVIEPGVMLRGKTVIGDDCVVTSGSEIVNSVIGERVHVRTSSIFESKVGDDVQIGPYAHLRPESDIHDHVKIGNYVETKKAVVGEGTKLPHFIYMGDAEIGKNVNVGCGSIAVNYDGKNKAKTIIGDNVFVGCNSNLIAPVKVGDRAFIAAGSTITKDVPEDALGIARAKQDNKLGYAKHLNHSK
>NC_003210.1|NP_463728.1|200521_200830_+|regulatory-protein-SpoVG
MQVTDVRLRRVETDGRMRAIASITLDEEFVVHDIRVIDGNNGLFVAMPSKRGVDGEFRDIAHPINSDTRAKIQEVVLAEYERVGEEEATAVTEEESESVSAE
>NC_003210.1|NP_463727.1|200093_200402_+|regulatory-protein-SpoVG
MEITDVRLRRVETDGRMKAISSITIDGEFVIHDIRVIDGNEGLFVAMPSKRTPDGEFRDIAHPINSGTRAKIQEAVLAAYEVADEPAVNEESSADESIVEEN
>NC_003210.1|NP_463726.1|198200_199409_+|ABC-transporter-permease
MNVLQSMKMAWKQLKASKLRSFLTMLGIIIGVASVILLVSLGNGVTQEVDDQMGDLGSNLITVVNSSVNPNDKYTYDEVMKYQNIDGVKSVSPELSGQVNATFDYKNSSNKVIGTNDQYKAARSLEMKEGRFLLPIDTEYGQKVAVIGSTVASDLFGFGDPIGETIRLNGMPYKVVGVLKEKGASMMGSSDDQIFIPISSAQRLLKDTNVRTIYVETKSAEDVDFVVNTLESRLAIKFGDEKEQEKNASSAQMGPSYQVINQQEILNAFNTISTTLTTALGAIAAISLVVGGIGIMNIMLVSVSERTREIGIRKALGAKKRAILLQFLIESIVISVCGGVIGIIIGVSGALIFGSVAGISSGITAGTIIFSFVFSLCIGVIFGIAPANKASKLRPIDALRSE
>NC_003210.1|NP_463725.1|197511_198204_+|ABC-transporter,-ATP-binding-protein
MPKPLIDMKNLTKTYTLGGETFKALDDVTFTVEQGEFLSIVGPSGSGKSTLMNMIGCLDVPDEGSYHLDDVDVFKLSDNKLSEIRNKKIGFIFQQFNLLPKLSAFENVELPLIYAGLSVSAREKAAIECLEKVGLLEKRRNLPTQLSGGQQQRVAIARALAGKPQILLADEPTGALDSKTGKEVMGILQELNRAGNTIVMITHDPTIASYGTRSIRIQDGKLFHEEATQA
>NC_003210.1|NP_463736.1|211424_212294_+|phospholipase-C
MKFKKVVLGMCLIASVLVFPVTIKANACCDEYLQTPAAPHDIDSKLPHKLSWSADNPTNTDVNTHYWLFKQAEKILAKDVNHMRANLMNELKKFDKQIAQGIYDADHKNPYYDTSTFLSHFYNPDRDNTYLPGFANAKITGAKYFNQSVTDYREGKFDTAFYKLGLAIHYYTDISQPMHANNFTAISYPPGYHCAYENYVDTIKHNYQATEDMVAKRFCSDDVKDWLYENAKRAKADYPKIVNAKTKKSYLVGNSEWKKDTVEPTGARLRDSQQTLAGFLEFWSKKTNE
>NC_003210.1|NP_463737.1|212365_212689_+|hypothetical-protein
MYIKGRLIFFFVVLVIALCSVLILLIIKISVWKDEPFHLSDAKEIECLGSCEIKNTNQKIHFFSIKENLFEEKGDIAGILNEDEQKVADKSIFIVILDDEKGIANEE
>NC_003210.1|NP_463738.1|212823_213285_+|hypothetical-protein
MKMLKKGTAVLFVMIMAVMLVACGDKEETKTYTLSQNGVDSKLTYTYKGDKVTKQTAENTMSYASLGVASKEDAEKMLKATSDKFQGIDGLKEKIEYKDDKAIETLEVDYTKISSEDMNKIPGMSSNGDTSKGISMEESAKMLESQGYKEVSK
>NC_003210.1|NP_463739.1|213335_213668_-|hypothetical-protein
MIVTTSPNIEGKQIIEYKKIVFGEVITGVNFMKDIGAGLRNFFGGRSQGYEDELINAREEAIREMEQRAKDIGANAVIGVDIDYEVLGADNGMLMVTASGTAVVIEAQDY
>NC_003210.1|NP_463740.1|213734_214409_-|hypothetical-protein
MITFDQLDTELQALENPNTIKIFRNHGCPDSLDLYGLKIGDLKKIIRREKLTKNHELAVKLIESNNSDLIYLGLLAINPNKITTEQIEKWNIAFRETWSQLTFGLASIVSKRDDALLFAKTWIESDYDLTKSMGWQIYSEHINNLPEAETLLQRAKETLQTETNRTRYSMNGFIITCGIYKDDLHEKAMEAAKSVGKVHVNLGNTACKVPDAISYIEKARNRTK
>NC_003210.1|NP_463741.1|214485_215427_-|L-lactate-dehydrogenase
MKDHQKIILVGDGAVGSSYAFACVNLSIGQEFGIIDIDKDRTIGDAMDLSHAVPFSTPKKIYSANYSDCHDADLVVVTAGTAQKPGETRLDLVNRNIKIMKGIVDEVMASGFDGIFLIASNPVDILTYATWKFSGLPKERVIGSGTSLDTARFRMSIADYLKVDARNVHGYILGEHGDTEFPAWSHTTVGGLPITEWISEDEQGAMDTIFVSVRDAAYEIINKKGATFYGVAAALARITKAILNNENAILPLSVYLDGHYGMNDIYIGAPAVVNRQGVRHIVEMNLNDKEKEQMKNSADTLKKVLDDAMKQID
>NC_003210.1|NP_463742.1|215720_216344_+|50S-ribosomal-protein-L25
MATTLEVQKRETTQHSEVTRLRSEGKVPGIIYGYKSENVPVSVDSLELIKAVRDNGRNAVFSVTVDGKKLNVLLHEYQVDPLKDVLVHVDLLAVDMNEEVETDVRVVLVGDAPGVKAGGVLQQIIHDVKVSATPEKLPETIELDISSLEIGDVLTTNDLPENKDYVVQAEEEETVVTVSAPRAEEEPTTTEAPEPEAVHGKDEEPVE
>NC_003210.1|NP_463743.1|216433_217018_+|hypothetical-protein
MLDKSVPHISVIMVNHDATNYPEFHLPAGYSFCFYKDGLEEDWCRLQLETGQVLSMDSIRARFETEFGNEKEKLTKRCIFVKAPNGEIIGTAMLWDGNTFGKIESRIHWVAVLDSHGGKGIAKALLSKILGLNKSKFVYLTTQTGSYQAIYLYRKFGFEKYVGKTPENWKTVNFQEEKETAWQIIENKIAEHQA
>NC_003210.1|NP_463744.1|217124_217685_+|peptidyl-tRNA-hydrolase
MKLIAGLGNPGKKYERTRHNVGFMVVDELSFRHQTPWKKSKFNGMTSEIIVGGEKMILVKPLTFMNASGECIRPLMDYYNIPIEDVVIVYDDLDLPVGKIRLRQKGSAGGHNGMKSIIQHVKTQEFNRIRVGVSRPLKGEVINYVLGDFPKAEQPDIIAAIQKSADAIEDFAQTPFIEVMNKYNQK
>NC_003210.1|NP_463745.1|217799_221339_+|transcription-repair-coupling-factor
MKGLQQLIYEQKDIRAVLNALDEKEKAQLVTGLTGSSRALFASVVEGASKRPVVFVTHNLYHAQKLYDDLLSLMDVDRLFLYPADELISSELSISSPELRGQRVEALDFLLSGKPGIVIVPVAGLRKMLPPVSLWKHFNISIVEGEEIDPDVLRQKLVTMGYTMSGMVNTPGEFSVRGGIIDIYPITEEFPIRIELFDTEVDSLRFFDVETQRSTTRVEEFRLLPATEIILDQSYYPDIVKRLEKKMMLTLNELKEQEDKQALIENLEEDLEMLRSGVKPDMFFKYIGLAYPDPASLFDYLPKNTAILLDEFGRILETEESLEREEAEWQTETLSRMETVRDVQVSHSFKKLLEGNHSPKIYLSLFQKQMASMRVSKTTNIVYKQMQQFHGQMNVLKTELESWHKNNYAVVILAPNLERAEKMQQTLTDYDMESTILKKESDVPKYGMVQFVIGTFQNGFELPLAKVAIISETELFNKKIKKVKKRQKLSNAERIQSYSELKVGDYVVHVNHGIARYVGMETLDINGVHKDYLLLVYQGEDKLFIPVDQLDLVQKYVGAEGKSPRLNKLGGAEWKRVKKKVQASVQDIADDLIKLYAEREAEKGYAFSADDEMQREFEEAFPYQETEDQLRSISEIKKDMERPRPMDRLLVGDVGYGKTEVALRAAFKAIMDGKQVAFLVPTTILAQQHFETMKERFQGFPIEIGLLSRFRTKKQQTETLKGMKNGTVDVVVGTHRLLSKDVEYQDLGLLIVDEEQRFGVTHKEKIKQMRSKIDVLTLTATPIPRTLHMSMLGVRDLSVIETPPANRFPVQTYVAEQNNVLVREAIERELARDGQVYYLYNRVESITQKADEISAMVPDARVATAHGQMGESELESVILSFLEGEFDVLVTTTIIETGVDIPNVNTLFVQDADRMGLSQLYQLRGRVGRWNRIAYAYFMYQKDKILREEAEKRLSAIKEFTELGSGFKIAMRDLSIRGAGNILGAQQHGFIDSVGFDLYSQMLKEAIEAKKPKEEQKQIVPVEIDIQADAYIPEYYITDGRQKIEMYKRFRNIETLSELEDLQSDMIDRFGEYPEEVEYLFTMTELKVRALEVGIESVKQEQNKITMLFSESGTAGIRGDIVMQIIGEFGRMVGVGMEGTQLKITINVQNKPLKEWLYQVKSLAEKLRGAMKEKASTEN

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Crispr_ID: NC_003210_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_003210_2

498828-499412

Orphan

Consensus_repeat	Method
GATGTAAGTNATTTTGATACNAGTTCAGTAACTNATATG	CRT

7 spacers

The CRISPR arrays of NC_003210_2

>merge|NC_003210|2|498828-499412|CRT
GATTTGAGTGGTCTTGATACTAGTGCGGTAACTACTATGTGGGATATGTTTAACAGCTGTAGGGCACTTGAGGAACTGGATGTAAGTCATTTTGATACAAGTTCAGTAACTAATATGTCTTACATGTTTTATGATAATAGAAATCTTGAGGTGCTGGATGTAAGCAACCTTGATACCAGTTCAGTAACTAATATGTATGCCATGTTTGAAGATTGTACTAGTCTTGAAGAGCTGGATGTAAGTCATTTTGATACGAGTTCAGTAACTGATATGTATAGAGTGTTTAATGGCTGTGAAAAACTGAAGAAACTAGATGTAAGTAATTTCGATACCAGTTCCGCTACTGCAATGGTTCAAATGTTTAGAAATTGTAGCGCCCTTGAGAAGTTGGATGTAAGTAATTTTAATACGAGCTTAGTAACTGATATGCGTGCCATGTTTGCTGGTTGTACTAGTCTTGAAGCGTTAGATGTAAGTAATTTTGATACGAGTTCAGTAACTAATATGGCTGCCATGTTTTCTGATAATGAAAAAGTGGAGAAGCTTGATTTAAGTACCTTTGATACCAGTTCAGTGACTAACATG

>NC_003210|2|1|498828-499412|CRT
GATTTGAGTGGTCTTGATACTAGTGCGGTAACTACTATG	TGGGATATGTTTAACAGCTGTAGGGCACTTGAGGAACTG
GATGTAAGTCATTTTGATACAAGTTCAGTAACTAATATG	TCTTACATGTTTTATGATAATAGAAATCTTGAGGTGCTG
GATGTAAGCAACCTTGATACCAGTTCAGTAACTAATATG	TATGCCATGTTTGAAGATTGTACTAGTCTTGAAGAGCTG
GATGTAAGTCATTTTGATACGAGTTCAGTAACTGATATG	TATAGAGTGTTTAATGGCTGTGAAAAACTGAAGAAACTA
GATGTAAGTAATTTCGATACCAGTTCCGCTACTGCAATG	GTTCAAATGTTTAGAAATTGTAGCGCCCTTGAGAAGTTG
GATGTAAGTAATTTTAATACGAGCTTAGTAACTGATATG	CGTGCCATGTTTGCTGGTTGTACTAGTCTTGAAGCGTTA
GATGTAAGTAATTTTGATACGAGTTCAGTAACTAATATG	GCTGCCATGTTTTCTGATAATGAAAAAGTGGAGAAGCTT
GATTTAAGTACCTTTGATACCAGTTCAGTGACTAACATG

Protein	Signature genes	Signature genes Name	Protein_function
NC_003210.1\|NP_463985.1\|491633_492917_+\|permease	unknown	unknown	gnl\|CDD\|271377
NC_003210.1\|NP_463981.1\|485492_487652_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376628
NC_003210.1\|NP_463996.1\|504673_504997_+\|hypothetical-protein	unknown	unknown	unknown
NC_003210.1\|NP_463993.1\|501692_501959_+\|transposase	unknown	unknown	unknown
NC_003210.1\|NP_463986.1\|492917_494018_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226065
NC_003210.1\|NP_463988.1\|496380_497919_+\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|368260
NC_003210.1\|NP_463992.1\|501311_501617_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|273478
NC_003210.1\|NP_463997.1\|504971_505277_+\|hypothetical-protein	unknown	unknown	unknown
NC_003210.1\|NP_463994.1\|502423_502660_-\|hypothetical-protein	unknown	unknown	unknown
NC_003210.1\|NP_463979.1\|483933_484599_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226146
NC_003210.1\|NP_463991.1\|500798_501284_+\|hypothetical-protein	unknown	unknown	unknown
NC_003210.1\|NP_463983.1\|488801_489749_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223786
NC_003210.1\|YP_008475629.1\|502197_502362_+\|hypothetical-protein	unknown	unknown	unknown
NC_003210.1\|NP_463995.1\|502898_504629_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379535
NC_003210.1\|NP_463987.1\|494010_495561_+\|hydantoinase	unknown	unknown	gnl\|CDD\|223223
NC_003210.1\|NP_463980.1\|484619_485375_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379782
NC_003210.1\|NP_463998.1\|505350_506223_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379523
NC_003210.1\|NP_463984.1\|489904_491500_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225306
NC_003210.1\|NP_463982.1\|487648_488797_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224635
NC_003210.1\|NP_463990.1\|500305_500779_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_003210.1\|NP_463985.1\|491633_492917_+\|permease	gnl\|CDD\|271377	cd11484, SLC-NCS1sbd_CobB-like, nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain. This NCS1 subfamily includes Escherichia coli CodB (cytosine permease), and the Saccharomyces cerevisiae transporters: Fcy21p (Purine-cytosine permease), and vitamin B6 transporter Tpn1. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. NCS1s belong to a superfamily which also contains the solute carrier 5 family sodium/glucose transporters (SLC5s), and solute carrier 6 family neurotransmitter transporters (SLC6s).	6.12636e-95
NC_003210.1\|NP_463981.1\|485492_487652_-\|hypothetical-protein	gnl\|CDD\|376628	pfam01841, Transglut_core, Transglutaminase-like superfamily. This family includes animal transglutaminases and other bacterial proteins of unknown function. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that form the catalytic triad in the structurally characterized transglutaminase, the human blood clotting factor XIIIa'. On the basis of the experimentally demonstrated activity of the Methanobacterium phage pseudomurein endoisopeptidase, it is proposed that many, if not all, microbial homologs of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease.	5.42265e-28
NC_003210.1\|NP_463986.1\|492917_494018_+\|hypothetical-protein	gnl\|CDD\|226065	COG3535, COG3535, Uncharacterized conserved protein [Function unknown].	0
NC_003210.1\|NP_463988.1\|496380_497919_+\|transcriptional-regulator	gnl\|CDD\|368260	pfam05043, Mga, Mga helix-turn-helix domain. M regulator protein trans-acting positive regulator (Mga) is a DNA-binding protein that activates the expression of several important virulence genes in group A streptococcus in response to changing environmental conditions. This domain is found in the centre of the Mga proteins. This family also contains a number of bacterial RofA transcriptional regulators that seem to be largely restricted to streptococci. These proteins have been shown to regulate the expression of important bacterial adhesins. This is presumably a DNA-binding domain.	1.17153e-19
NC_003210.1\|NP_463992.1\|501311_501617_+\|hypothetical-protein	gnl\|CDD\|273478	TIGR01167, Zinc_metalloprotease_ZmpB, LPXTG-motif cell wall anchor domain. This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region. [Cell envelope, Other].	4.04229e-05
NC_003210.1\|NP_463979.1\|483933_484599_-\|hypothetical-protein	gnl\|CDD\|226146	COG3619, COG3619, Predicted membrane protein [Function unknown].	6.55182e-68
NC_003210.1\|NP_463983.1\|488801_489749_-\|hypothetical-protein	gnl\|CDD\|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	1.51988e-102
NC_003210.1\|NP_463995.1\|502898_504629_+\|hypothetical-protein	gnl\|CDD\|379535	pfam14280, DUF4365, Domain of unknown function (DUF4365). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria, eukaryotes and viruses. Proteins in this family are typically between 182 and 530 amino acids in length. There is a single completely conserved residue D that may be functionally important.	5.7395e-10
NC_003210.1\|NP_463987.1\|494010_495561_+\|hydantoinase	gnl\|CDD\|223223	COG0145, HyuA, N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	1.31898e-105
NC_003210.1\|NP_463980.1\|484619_485375_-\|hypothetical-protein	gnl\|CDD\|379782	pfam16160, DUF4866, Domain of unknown function (DUF4866). This family consists of uncharacterized proteins around 250 residues in length and is mainly found in various human gut Firmicute species and abundant in human gut metagenomic datasets. The function of this family is unknown.	3.03926e-122
NC_003210.1\|NP_463998.1\|505350_506223_+\|hypothetical-protein	gnl\|CDD\|379523	pfam14253, AbiH, Bacteriophage abortive infection AbiH. This family of proteins confers resistance to bacteriophage.	0.00907293
NC_003210.1\|NP_463984.1\|489904_491500_+\|hypothetical-protein	gnl\|CDD\|225306	COG2508, COG2508, Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism].	1.08474e-59
NC_003210.1\|NP_463982.1\|487648_488797_-\|hypothetical-protein	gnl\|CDD\|224635	COG1721, COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only].	2.48336e-53

>NC_003210.1|NP_463988.1|496380_497919_+|transcriptional-regulator
MREYLDSKSQKKVALLEKIFYAENHTSTQEELLNDLNITYPTLISTIKTINFDIERFGYKAFSIVHSAPNLSYTLKISDNCSIQLIINAYIRESPKFQILETLLLASFPNLQALAKKVHVSYSGIKKEIKELNEELRERNLSISTGNQVEITGDEFSLRIFYAFLFLVTYSGDRWPFSFVQYDEITDLLESCPKEIYRANSIDKGMMIHYYVAMHLLRDRMNCQIDTTRQFKVALYKACTEESKKSESAFIKKVAKQLPNRNYKEITYTTQIILSTIVAFGSYSSIEKMPSFFYMDEQLEEMGFMKLVDFASERVNDNLSIPFSEKEMELLRYSFASINYRYFLLDNLINKFNNIVPGYTDLDRNIRKIHKVNHLEPLISQLVNLKEMRLLKPFEEKLASDYLIILDKRIDFSIHTLPIKVTILSTISNETAVFDFMRYFSSYYNLEIINQVDPVVDLYISDFSVSPEVLTSLRINQPIVYVNTRWLESDYVKINDNLAKIARKKFIANKKD
>NC_003210.1|NP_463987.1|494010_495561_+|hydantoinase
MYKIGIDVGGTNTDAVILDENQQLIHSVKMPTSEDIETGITESLHRVLSETGIDRSKVTHAMLGTTQCTNAIVERKKLAKVGVLRLGYPATASVLPYTAWPEDMVGFLSGKYKLTGGGYEYDGQVLSEINEAEIRETLASWKGEVESVAVVGVFSSLKNDQELAVQKIIEEELGADIPVSISSSVGSVGLIERENATILNAALFKVIAATSDGFEKALEQEGIEHAEIYLCQNDGTLMSLNYARQFPILTIACGPTNSIRGASYLAGLKDAMVLDVGGTTSDIGVLTDGFPRESSLAVDVGGVRTNFRMPDIISIGLGGGSIVREKDGDITIGPDSVGYRISEEALVFGGKTMTTTDIAVRLGMAEIGNPELVAHIPTDFAEKAYKKIADMTEDAIDKMKTSSGSVSLVLVGGGSVIIPDEISGVAQIFRDKNGPVANAIGASISQISGQYEQIYIYSQIEREEALQDAEQKAREQATLAGAVTDSIEVVEVEEIPLAYHPGNATRLRVKVVGNLV
>NC_003210.1|NP_463986.1|492917_494018_+|hypothetical-protein
MRYLDEQAIENIAIGAAFLGTGGGGDPYIGKMMALTAIKKHGPIKLLSPEEIADDDYFIPAAMMGAPSVLIEKFPKGDEFVRVFEKLGRYVGKEVKGTFPMEAGGVNSMIPIVVAAQLGLPMVDCDGMGRAFPELQMVTFHLDGISATPMAITDEKGNIGIMETIDNKWTERLARVTTVEMGASSLVSLYPCNGAQIKQSSIKNIVTLSEEIGKVIRETSMDEAEKLQKLLDVTHGYHLFEGKITDVVRETRAGFNFGRVKIDGLNKDTNSEVIVHFQNENLVAEKNGEPIAITPDLICMVDLETLMPVTTEALKYGKRVRVMALPADDAWRTDKGIETVGPRYFGYDVDFEPLEELVKKEERRHV
>NC_003210.1|NP_463985.1|491633_492917_+|permease
MTEKKTVEQAQSWQSLAFVWTGAMICVPSLLVGGTLISGMPLWEAILIALLGYGVIVVFMIYQGMQSSDLGIPAVSVASQVFGEQGSKKIISILLAIACLGWFGIQANVCGAAFSQFLGIYGINLPVPVSSLIWGVIMLLSAIYGIRILSILNYIAVPILLFVCIYGLVVSLNNGGLAVVENYKPAGSMSFMTGLAITIGSFALGAVIAGDYSQYTKSRKDVVKAAIVGILPSGVLMIAVGAILALTAGTADISVVFTNLGLPVLGIIGLILAAWTTNAVNAFSGGIAIINVFNISEKYHKVAVAIAGGLGTVLAVIGILNHFVPIMSVLSAMVPPVAGVMIASYWIVQKGDKSKWAPVPGVNWLGVTSWLVGAVIAGIPVILTFFPALPQLPNQPLIGIILSLAVYLVGAKVLSGKTNNVENLEGK
>NC_003210.1|NP_463984.1|489904_491500_+|hypothetical-protein
MSVKLADLMKLPSLKEAKVVSGKSGLSKLVSSISVLEYTEVALLEDDLFDNDEFYGSEIVVSAFVNIRDDVEAQCRTIERLHKVGEVALILYYVGIFVPKMDQKLIDFANELDFTIIVMPENEMSLRYSEVIYEVVEAIVKQEMTDTNFVTESLEQISSVRPPQRNIDTTLKILSDRTHSSLVLTDNSFQVINSITWPRTRHWDFERVIETSKQIDEHELVQLHLDERDFYTARKPIFQDGMQAMHLFMMKEKGALTADVVMQITEVVQVFMNLWGRNYVEISTAELMKAILNDESVKMRRLGKILNVDVSSIKWMWLVKTEEIRNNEQVLAELKSFVASHFQVSLIDLFEDNIVVLLDNSVGQRDRTHTANEFAMMMKEHGIDLKITVCQGMEQTSDVQSAYSLVNEYKNAANAIYANKSIYSLQEIDFAAKCVEIVDRGELAIAEQMRPLKSLEDNDELIETLSVFLLEGESNYNQAAELLFLHKNTIKYRIQRINELLQYPATKIPESYNLYLAVAIRRLLGGNNNNK
>NC_003210.1|NP_463983.1|488801_489749_-|hypothetical-protein
MSIEPSIKINEIINEVEKVIVGKRHVVKLSLTALLAGGHVLLEDVPGVGKTMMVRTLSKTIGVSFKRIQFTPDLLPADVTGVSIFNPETRDFEFRPGPVMGNIVLADEINRTAPRTQAALLEGMAENSVTVDGITRKLANPFFVMATQNPIEYEGTYALPEAQLDRFLLKINIGYPTVEEEMQLLTLKQYQDPLDQTKQVVTLSELLDLKNKAKQVFIDDVLKNYIIRLVDATRKHPSVALGISPRGSLAFMQAAQAFALIEGRDYVIPDDIQYLAPYIFTHRLILKSEAYYNEETAESIIASILKNTSVPVEKR
>NC_003210.1|NP_463982.1|487648_488797_-|hypothetical-protein
MLKKRLLLASRWIIMLIIYAGLWTYTLFQGDTASWFLTYFFSFILLLLFLSSIYPLKAWKVNRSFVKNTYHDGDLIDMQVSFTRKSRYPVGYLLFQQKIPATFGKVRARQQVVYPLFKKQFTVTLAGFVGVRGIHSFPPVDVETSDAFGLLERSRQLSSEKSLTIYPTYFPNVLEKISEASPENERNAAYWTLKKNSNLHSLREFSSGDRISLIDWKSSAKSDQLMTREFENSATSRLSVIFYGASHPNFELSLRAAYSFIRKISEENGEIRVTLLGDQTSKFAPAKGTSRLQDISTAFAEIAPVDSLTLQESLDSNLHSGEKILLFTPCMDTMLMQKVTRLTDNKQLQIITFQSEHSKAMDAPAIFLEQASLLSRWERETK
>NC_003210.1|NP_463981.1|485492_487652_-|hypothetical-protein
MKRYLTLVMLFILSVLLISEWIYPFAELTELSTATWIILFITLSLGSFFLRLKYYWTIPLHVVMIIIVSGIYYAKGGILAGNWLGSFFQITFNGFRDMVQFRSSDISMDFILIVFLIALWLLSYITTYSILRKQRIMSVLVLTVAYLAVINTFTDYNSNWAIVRTVLEGFLLLHLALASRIATPNRISADSLKRNGLFYHGFVILLLAVFVFSSLMLPKKAPIFPDPIPTIKNALGINTTRTVGYSEDDTTLGGALKKDNATVFTAQAEKGHYWRVESKTVYTGTGWANANSGDVISFSSGDNFPIQLTEQTTGATNTAEISFASSSDYMPYPYGTQAVNGAVDSFSANLTIERVGPVDTIKNYTVQLKTPVYNIEKMQNADFSTLSNAFVSQYTQTPKDLPDRVTKLANKVTKDADSIYDKTKAIESYLSTSGTFTYSTDDAKETPMGADYVDQFLFETQIGYCDNFSTSMVVMLRSLGIPARWAKGYTPGEGEKKENDAKTTYTITNNNAHSWPEVFFPGTGWVPFEPTATFSNPENFQEPTTETANKPETPNDSTSTPETPNTPDKTPEQDNGSSSTGETPKKEEPKTETATSNVEIPSWVWWIPAGLVVALLALAIVFRRRIRGYLLLRSLRNSPEFGKTYHRLMKLLASYGYVRESSETLRHFSARVDADLTTSEFSRLTKMYETQLYSKNLTEKVIAAKETQLVQQIIARLTK
>NC_003210.1|NP_463980.1|484619_485375_-|hypothetical-protein
MTTIFPKEQNVTPLFEQILANPTACRRFKDVFLDNLESYQETRGFEKDDTLFAKIILSAYRQSDVSALLLGVCGRTLFELLRQAFLIPKKLTVDNPFFLTDKEGNFIAKKDDISNREQEKFQEIYQSDLHHSETTIFLVDDDDIVHSYEPDFSISTKRINKKRGILVLYSLPDTLKSGMTESEVYAFIWKTFLHIQEIIPSSRIFYGQETSENADELGVFLPIHHFEKKMLQNIEQVNELVDALREQMVNK
>NC_003210.1|NP_463979.1|483933_484599_-|hypothetical-protein
MARTRQISESIGLGLLLALAGGFMDAYSYIERGQVFANAQTGNILLFGINISEGNWAIAIQYFWPVVSFTVGIALSEVIHRRDIRRLHWRQLSVLIEAVILIGVAFIPLDHNLIANSLISFVCGIQVESFRKMHGRGVATTMCIGNLRSATQNLCDYFEYKEKQYLHNSFLYFSVILSFIIGAVVGNFFIQLFAQYAILVCAFLQLIAFMMMFIDRESKII
>NC_003210.1|NP_463990.1|500305_500779_+|hypothetical-protein
MKKKKVVVISLLLLLVSVIGISSYFLFKDKINLLDVDPSAVEWNGKKQKDTSGEENTIAIPGFEKVTLYANETKQAVNFHNPEINDCYFKISLIHPDGSVLWRSDLIEPGKGMYSIELEKTLAVGEYENAVLKYECFSLNDQSPLNGSEINLKLVVV
>NC_003210.1|NP_463991.1|500798_501284_+|hypothetical-protein
MNKLVLSTLSVAAMGMVIFSGGTAYAADKEGNTVVEYSVEGDYTLVVPEKVNLSNDNATEMSVKTINRNLEPGKEVEVTLSSGLSADGEIELERVGATSDVITSSFKSNNSTVTMANPVIGSFSGYAIEETEVSKIQIGSPQGDKKAGAYQTTLTFTAAFK
>NC_003210.1|NP_463992.1|501311_501617_+|hypothetical-protein
MKRKLVLAMVLISFCGMFLLSPERVQASQTVVEVFISEDDLDVSEENIQEIPKKELAASSDKDNKQHMLPKAGDTVTNYTLLGLVLVLIWLIMQRKRKKKE
>NC_003210.1|NP_463993.1|501692_501959_+|transposase
MARIEYGEEIQKSLLVLYSRGSTIDSICKEYGIPRYEFHKWMKLHDADKLETKEVKTLLQIRELKQQKNKLEEEILFLNEAINLLESP
>NC_003210.1|YP_008475629.1|502197_502362_+|hypothetical-protein
MYVESKEELEKIIYQQLINNINVKPDPWKWEERNALIVEIEVKAVLEKYGSTPI
>NC_003210.1|NP_463994.1|502423_502660_-|hypothetical-protein
MSLKKILESDESIEKKEQQIDSYYQSELITRVEACELLDVSTKSLDRYIKQNKLSFQLNSLLIPHFCLIVLLMPLAIL
>NC_003210.1|NP_463995.1|502898_504629_+|hypothetical-protein
MVKYTNPKIEKLGVNAVSNYIVESDYLSDFLAQQSTEPATDGTIRIYNGPGERKRDLIGIVPVQVKGTTTKNIIKYNRHEIDIVDLTYYYKVGGVVYFVVYVTNKVPKIYYRDLLRIDIKEILKKNEKLRGKKEKGTITIDFREVPVNVEDFRTVLLNFHKDQDYQTKDYVELGSINEISRDLTFTIIAPNSNIVEALKYVSPVLYKNEGDLKIPVRRFKIGELSVFTKSEFSIGIKGANSYIATVMEGEEETEIQIGSLQQLIVKFKEGRFKVDFEAKGKIQETIELLEILLGIVTGVNLYIDNKPVTEFFIEEVNEDFISRVNHALESFKKTQEALNHCKVPSNFHYEELTENDIDVINSIMELYQTSIDNTWGKFEFNNRLVYLLKHKGTIYNLLDSNVALEINFWSKREDGIQYTTTPLILIDDFSKMNDTEICNIKGPIEKLIPIHEKACSDINLICVRLIDAYDQTNNNQFLLVAFELLELIIPFTTNNEIHLIYLNKYQIKKRWDNLVMEDINHLVSIQKEFEEDKRIHLATLILLSAKNDAAQLLSELKNNEGFSLEDMPILNLLEKN
>NC_003210.1|NP_463996.1|504673_504997_+|hypothetical-protein
MYQKASEKMKETMKANIALVESIRISSISNKKLQSDNKSGHTVVTFKDNKWVARICVSGVEHQLGSFVTKEEAIDARIEGEKYFQPLINKYNNRLDVFYSERRPFWT
>NC_003210.1|NP_463997.1|504971_505277_+|hypothetical-protein
MNVDPFGRKVELMIIGNGLDVKANLASTFVDYYKHRCKLMRLEYNEDDFYRLKSKNYFPMKVKMQQFPSIRRCNIEILSIDAETAINENITFWDLVLFFCL
>NC_003210.1|NP_463998.1|505350_506223_+|hypothetical-protein
MSDPINIILNNCGFGENLEDEQENDLYNLMEERLEEKDKYVLSVAFIHKLNSYSNCSLEEFLMLELNKYEKYFSDYIKTEVTNKYEEYHKTRNNILTKLSGGLGATHSISVMNFNFTPNQFSDSVKLNEKIGLAHVNVHGSYLANSIFGIDTKSLEDIDTIGSGYRFTKTYRKLTLKTKRSTEILYHDITDIIFYGHSLGQADYAYFQSIFDYLDIYNNTIVLTFYYSDYKENVREEQTIAVRNLIEEYGKTFDNKHKGKNLLHKLLLEERISVTDLEIYEEDYSSKDMK

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Click the colored protein region to show detailed information

Crispr_ID: NC_003210_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_003210_3

544375-544663

Orphan

I-A

Consensus_repeat	Method
GTTTTAGTTACTTATTGTGAAATGTAAAT	PILER-CR
GTTTTAGTTACTTATTGTGAAATGTAAAT	CRISPRCasFinder
GTTTTAGTTACTTATTGTGAAATGTAAAT	CRT

4 spacers

The CRISPR arrays of NC_003210_3

>merge|NC_003210|3|544375-544663|PILER-CR,CRISPRCasFinder,CRT
GTTTTAGTTACTTATTGTGAAATGTAAATCGATAAAAAAGATATTAGTAATTTATTTGCAATTTAGTTTTAGTTACTTATTGTGAAATGTAAATTGCTCTCTTTTGTGTAAAGCACATCAAGCATGTAGCGTTTTAGTTACTTATTGTGAAATGTAAATGCGATTTTTGTCAAAGGGACAGCGATGGGTTACAAGTTTTAGTTACTTATTGTGAAATGTAAATTTACCACCAAAGTCCCTACACTCAATACCACCAAAGCGTTTTAGTTACTTATTGTGAAATATAAAT

>NC_003210|3|1|544375-544663|PILER-CR
GTTTTAGTTACTTATTGTGAAATGTAAAT	CGATAAAAAAGATATTAGTAATTTATTTGCAATTTA
GTTTTAGTTACTTATTGTGAAATGTAAAT	TGCTCTCTTTTGTGTAAAGCACATCAAGCATGTAGC
GTTTTAGTTACTTATTGTGAAATGTAAAT	GCGATTTTTGTCAAAGGGACAGCGATGGGTTACAA
GTTTTAGTTACTTATTGTGAAATGTAAAT	TTACCACCAAAGTCCCTACACTCAATACCACCAAAGC
GTTTTAGTTACTTATTGTGAAATATAAAT

>NC_003210|3|2|544375-544663|CRISPRCasFinder
GTTTTAGTTACTTATTGTGAAATGTAAAT	CGATAAAAAAGATATTAGTAATTTATTTGCAATTTA
GTTTTAGTTACTTATTGTGAAATGTAAAT	TGCTCTCTTTTGTGTAAAGCACATCAAGCATGTAGC
GTTTTAGTTACTTATTGTGAAATGTAAAT	GCGATTTTTGTCAAAGGGACAGCGATGGGTTACAA
GTTTTAGTTACTTATTGTGAAATGTAAAT	TTACCACCAAAGTCCCTACACTCAATACCACCAAAGC
GTTTTAGTTACTTATTGTGAAATATAAAT

>NC_003210|3|2|544375-544663|CRT
GTTTTAGTTACTTATTGTGAAATGTAAAT	CGATAAAAAAGATATTAGTAATTTATTTGCAATTTA
GTTTTAGTTACTTATTGTGAAATGTAAAT	TGCTCTCTTTTGTGTAAAGCACATCAAGCATGTAGC
GTTTTAGTTACTTATTGTGAAATGTAAAT	GCGATTTTTGTCAAAGGGACAGCGATGGGTTACAA
GTTTTAGTTACTTATTGTGAAATGTAAAT	TTACCACCAAAGTCCCTACACTCAATACCACCAAAGC
GTTTTAGTTACTTATTGTGAAATATAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_003210.1\|NP_464046.1\|552562_552931_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226282
NC_003210.1\|NP_464039.1\|545608_546289_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|153212
NC_003210.1\|NP_464041.1\|546679_547138_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378956
NC_003210.1\|NP_464029.1\|536186_538247_+\|transcriptional-antiterminator-BglG	unknown	unknown	gnl\|CDD\|226234
NC_003210.1\|NP_464047.1\|553077_554493_+\|multidrug-resistance-protein	unknown	unknown	gnl\|CDD\|129794
NC_003210.1\|NP_464034.1\|540420_541467_+\|sorbitol-dehydrogenase	unknown	unknown	gnl\|CDD\|176198
NC_003210.1\|NP_464044.1\|549915_551346_-\|encapsulation-protein-CapA	unknown	unknown	gnl\|CDD\|225399
NC_003210.1\|NP_464038.1\|544922_545501_+\|hypothetical-protein	unknown	unknown	unknown
NC_003210.1\|NP_464030.1\|538250_538853_+\|sugar-phosphate-isomerase	unknown	unknown	gnl\|CDD\|223865
NC_003210.1\|NP_464045.1\|551466_552282_-\|phosphoglycerate-mutase	unknown	unknown	gnl\|CDD\|223483
NC_003210.1\|NP_464042.1\|547519_549337_+\|internalin	unknown	unknown	gnl\|CDD\|380190
NC_003210.1\|NP_464033.1\|539773_540424_+\|ribulose-5-phosphate-3-epimerase	unknown	unknown	gnl\|CDD\|223114
NC_003210.1\|NP_464032.1\|539364_539763_+\|hypothetical-protein	unknown	unknown	unknown
NC_003210.1\|NP_464037.1\|543201_544137_+\|phosphoribosyl-pyrophosphate-synthetase	unknown	unknown	gnl\|CDD\|234929
NC_003210.1\|NP_464040.1\|546313_546673_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|131113
NC_003210.1\|NP_464031.1\|538880_539348_+\|PTS-fructose-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|238129
NC_003210.1\|NP_464028.1\|535427_536078_+\|transaldolase	unknown	unknown	gnl\|CDD\|223254
NC_003210.1\|NP_464043.1\|549437_549869_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366180
NC_003210.1\|NP_464035.1\|541482_541776_+\|PTS-galactitol-transporter-subunit-IIB	unknown	unknown	gnl\|CDD\|99908
NC_003210.1\|NP_464036.1\|541790_543062_+\|PTS-galactitol-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|226298

Protein	Function_ID	Function_description	E-value
NC_003210.1\|NP_464046.1\|552562_552931_-\|hypothetical-protein	gnl\|CDD\|226282	COG3759, COG3759, Predicted membrane protein [Function unknown].	2.33548e-41
NC_003210.1\|NP_464041.1\|546679_547138_-\|hypothetical-protein	gnl\|CDD\|378956	pfam12802, MarR_2, MarR family. The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.	9.15558e-13
NC_003210.1\|NP_464029.1\|536186_538247_+\|transcriptional-antiterminator-BglG	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	5.36772e-80
NC_003210.1\|NP_464047.1\|553077_554493_+\|multidrug-resistance-protein	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	3.18163e-80
NC_003210.1\|NP_464034.1\|540420_541467_+\|sorbitol-dehydrogenase	gnl\|CDD\|176198	cd08236, sugar_DH, NAD(P)-dependent sugar dehydrogenases. This group contains proteins identified as sorbitol dehydrogenases and other sugar dehydrogenases of the medium-chain dehydrogenase/reductase family (MDR), which includes zinc-dependent alcohol dehydrogenase and related proteins. Sorbitol and aldose reductase are NAD(+) binding proteins of the polyol pathway, which interconverts glucose and fructose. Sorbitol dehydrogenase is tetrameric and has a single catalytic zinc per subunit. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Related proteins include threonine dehydrogenase, formaldehyde dehydrogenase, and butanediol dehydrogenase. The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit. Horse liver alcohol dehydrogenase is a dimeric enzyme and each subunit has two domains. The NAD binding domain is in a Rossmann fold and the catalytic domain contains a zinc ion to which substrates bind. There is a cleft between the domains that closes upon formation of the ternary complex.	0
NC_003210.1\|NP_464044.1\|549915_551346_-\|encapsulation-protein-CapA	gnl\|CDD\|225399	COG2843, PgsA, Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane].	2.95496e-100
NC_003210.1\|NP_464030.1\|538250_538853_+\|sugar-phosphate-isomerase	gnl\|CDD\|223865	COG0794, GutQ, Predicted sugar phosphate isomerase involved in capsule formation [Cell envelope biogenesis, outer membrane].	1.15952e-75
NC_003210.1\|NP_464045.1\|551466_552282_-\|phosphoglycerate-mutase	gnl\|CDD\|223483	COG0406, phoE, Broad specificity phosphatase PhoE and related phosphatases [General function prediction only].	5.01016e-50
NC_003210.1\|NP_464042.1\|547519_549337_+\|internalin	gnl\|CDD\|380190	NF033186, internalin_K, class 1 internalin InlK. Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface-anchored proteins with an N-terminal signal peptide, leucine-rich repeats, and a C-terminal LPXTG processing and cell surface anchoring site. Members of this family are internalin K (InlK), a virulence factor. See articles PMID:17764999. for a general discussion of internalins, and PMID:21829365, PMID:22082958, and PMID:23958637 for more information about internalin K.	1.81836e-118
NC_003210.1\|NP_464033.1\|539773_540424_+\|ribulose-5-phosphate-3-epimerase	gnl\|CDD\|223114	COG0036, Rpe, Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism].	4.74405e-108
NC_003210.1\|NP_464039.1\|545608_546289_+\|hypothetical-protein	gnl\|CDD\|153212	cd01741, GATase1_1, Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain. This group contains a subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain. GATase activity catalyses the transfer of ammonia from the amide side chain of glutamine to an acceptor substrate. Glutamine amidotransferases (GATase) includes the triad family of amidotransferases which have a conserved Cys-His-Glu catalytic triad in the glutaminase active site. In this subgroup this triad is conserved. GATase activity can be found in a range of biosynthetic enzymes, including: glutamine amidotransferase, formylglycinamide ribonucleotide, GMP synthetase , anthranilate synthase component II, glutamine-dependent carbamoyl phosphate synthase, cytidine triphosphate synthetase, gamma-glutamyl hydrolase, imidazole glycerol phosphate synthase and, cobyric acid synthase. Glutamine amidotransferase (GATase) domains can occur either as single polypeptides, as in glutamine amidotransferases, or as domains in a much larger multifunctional synthase protein, such as CPSase.	9.06055e-60
NC_003210.1\|NP_464037.1\|543201_544137_+\|phosphoribosyl-pyrophosphate-synthetase	gnl\|CDD\|234929	PRK01259, PRK01259, ribose-phosphate diphosphokinase.	1.26262e-153
NC_003210.1\|NP_464040.1\|546313_546673_-\|hypothetical-protein	gnl\|CDD\|131113	TIGR02058, lin0512_fam, conserved hypothetical protein. This family consists of few members, broadly distributed. It occurs so far in several Firmicutes (twice in Oceanobacillus), one Cyanobacterium, one alpha Proteobacterium, and (with a long prefix) in plants. The function is unknown. The alignment includes a perfectly conserved motif GxGxDxHG near the N-terminus. [Hypothetical proteins, Conserved].	5.62162e-67
NC_003210.1\|NP_464031.1\|538880_539348_+\|PTS-fructose-transporter-subunit-IIA	gnl\|CDD\|238129	cd00211, PTS_IIA_fru, PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.	2.76446e-37
NC_003210.1\|NP_464028.1\|535427_536078_+\|transaldolase	gnl\|CDD\|223254	COG0176, MipB, Transaldolase [Carbohydrate transport and metabolism].	5.85703e-62
NC_003210.1\|NP_464043.1\|549437_549869_+\|hypothetical-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	4.03126e-27
NC_003210.1\|NP_464035.1\|541482_541776_+\|PTS-galactitol-transporter-subunit-IIB	gnl\|CDD\|99908	cd05566, PTS_IIB_galactitol, PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain that are expressed on three distinct polypeptide chains, in contrast to other PTS sugar transporters. The three genes encoding these subunits (gatA, gatB, and gatC) comprise the gatCBA operon. Galactitol PTS permease takes up exogenous galactitol, releasing the phosphate ester into the cytoplasm in preparation for oxidation and further metabolism via a modified glycolytic pathway called the tagatose-6-phosphate glycolytic pathway. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include galactitol, chitobiose/lichenan, ascorbate, lactose, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.	3.06007e-27
NC_003210.1\|NP_464036.1\|541790_543062_+\|PTS-galactitol-transporter-subunit-IIC	gnl\|CDD\|226298	COG3775, GatC, Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism].	7.01085e-178

>NC_003210.1|NP_464037.1|543201_544137_+|phosphoribosyl-pyrophosphate-synthetase
MAGKMKLFSVTSERPLATKIADYLDIPLCEVELQKFSDGEVKINIEESIRGTNAYVVQSMNSNVNERLMELLIMVDALKRASVHSINIIMPYYGYARQDRKARSREPITAKLMANLIQRAGANRLITVDLHAAQIQGFFNIPIDHLSAIPLIGDYLIENYGEKDVVVVAPDHSGVVRARRIADRLNAPIAILNRKPRPHEDEIMSVIGDVKGKVAIVVDDIIDTGVRATTSADILLEKGAVEVIACATHSVMAGNATERLQNSNIKEVITSDSIDLPEDKQFDKLTTISIGRILGRAIEGVQENRSLHPLF
>NC_003210.1|NP_464036.1|541790_543062_+|PTS-galactitol-transporter-subunit-IIC
MDIILDFFKYIIGLGVTVMMPIIITILGVIFRKKISVAFKAGLTVGVGFVGLGVITSLMLTTITPVTKALVENYNFKLTATDIGWGVGSSLAWGTEVVPFVFVAIIATNILMIAFKWTKTMDVDIWNYWQPLFIASALYLTTGSMIIAVLSSIINMAIIFKIADWTQKDVEDVLGLEGISLPQIQTTGWALVGYPMNWLLGKIPGVRKINWSTEKVQSRLGIFGEPMLMGLIIGGGLAAIAQMPLSQVLQTGVTIAASLVLIPRMVSLLMDGLTVISEAAHEFMEKRFPGRELFIGLDSAVGIGHPFVLSLGLLMIPITLILAFILPGNKVLPLADLTALPFYMIFAIVPSKGNLFRGIFTGIVIVIITLYLSGAAAPLMTELAGQIGYNIPKDAVEVTSLAVGTQWYTWIVYYGLHWFGGIL
>NC_003210.1|NP_464035.1|541482_541776_+|PTS-galactitol-transporter-subunit-IIB
MKKKRIYVCCGTGIATSTVISKKVRAVLDEKRIPYEISQCTVQEVASKVSTSKPDIIVSSTTVTGDVGDVPVVIGRSFLTGLKKQETIDEILAILQD
>NC_003210.1|NP_464034.1|540420_541467_+|sorbitol-dehydrogenase
MKALKLYGKRDLRYEEADMPTIEEPDDVILKVKTVGICGSDISRYSKLGPYVPGMVWGHEFSGEVIEVGSEVTDIEIGDRAAGCPALYCGECEYCKKGEFARCRKLTVIGARHPGAYAEYIKLPAENVVKIPNELDYEAAALVEPSAVVVHGFYHTKLQAGDDVVVVGSGNIGLLAIQWAKVFGARRVIAIDVDDKKLALAKEVGADVVINSLKEDPLEVVAAHTDGLNADLVVEAAGSPITSAQVFAYAKKGGGVVFLGIPYADVTIERFYFEKIVRSELTVWGSWNAISAPFPGKEWQTTIHFLANKQINIEPMITHRLSLAEGPEVFERIYERNEFFGKVLFFPE
>NC_003210.1|NP_464033.1|539773_540424_+|ribulose-5-phosphate-3-epimerase
MAKIVPSVFGADIGRINEQLQVLEKNDIDLLHVDMMDGSFVPNIAFGPDQIKMMKKGTKLQFDVHMMVYEPDRYIPRLVEAGAHMITVHQEATTHLHRTIQLIKSYGVRAGVVLNPGTPPSTLEYVLDDIDCILLMTVNPGLGGQKFFQSSLEKIRKTKAYIGNRPIQIEVDGGVNDELAKECTLAGADLIVVGSYLFEGDIEANLEKLAKGVLTE
>NC_003210.1|NP_464032.1|539364_539763_+|hypothetical-protein
MGSFFASFVDWLIGSPGRFVVNLIEDNMLIFMVVVMIYATTILYAKWTLAYYLPKKMSQLAEMKTWELDELYAAWQTEKKALPWYILVPSRNEFWVKSARNAPESTKLLHFSQQKLKLSDKEKLQKIIEIQS
>NC_003210.1|NP_464031.1|538880_539348_+|PTS-fructose-transporter-subunit-IIA
MDVLEYFKEEMVRFSNEQNKEKLLAEMAEQLCEVGAVKPSYKDAVIKREKVFPTGLLTAHAGVAIPHTDSEHVIRPVVAVRILKKPVSFIEMASDNEAIDVRIVFMMALRSADEQLDMLQTLIQLIQDEEVMTTLLKAQETGDVLSAIEHFSKNN
>NC_003210.1|NP_464030.1|538250_538853_+|sugar-phosphate-isomerase
MDKQAILNNIHQTWQEEANAISRLPEVTSEEALVKTVEKIAECTGKIVVAGCGTSGVAAKKLVHSFNCIERPAVFLTPSDAVHGTLGVLQKEDILILISKGGNTGELLNLIPACKTKGSTLIGVTENPDSVIAKEADIFFPVSVSKEPDPFNMLATASTMAVIASFDAVIVCLMTYMNYTKEQFSVIHPGGAVGNKLLNK
>NC_003210.1|NP_464029.1|536186_538247_+|transcriptional-antiterminator-BglG
MYLDNRSKTLFQEVIKNPNITNKQLEVKYKLSRYQISYSFQKVNEWLKWKNYPEVKRSKNGRFILEPELTALFSEKETRDPSVEYLPSENERANLILLMLLTSKEELSLAHFTTKIQVSKNTILRDLKVAQKLLPKETTVTYSRASGYQLAGSEWELRKVLTQVVSSVKEMFRGEHYFLSYSGIEKVQLMEIRRTLEEAEAMMQIKFTYEQIELLPYLLSVMFLRIRDRRLIDTAFHIDEKSLSDTREYHITDILLEKTGPVPEQERLFITLQLLTTNIFSGEILTEKLTEDLEKVVLTCLDLFEKKALVSLKNKHILIEKLLLHLKPAYYRIKYQMNLEDTLYEKFNQEFEALNFIVKEAFDPLAKFIGREIPAGEIFFISLFIGSDMIPQNDIYHKQKRAIVLCPSGVTFSKIMENILVKLFPEIHFYPTISVREYAFFKAEVDIVFSSIPLKDGENVFVVQPFMNDIEKTQLRQHVLQNLFGMGNQLTSIDKIMEVVERNADIKDPNAIRDGIIDILSANIATDENKRVKKVYLHDLITEDNIMICEDVKNYQEAIRLASQPLLLQQAITANYVKTMIDNHKFHDPYIIIGEDIAIPHAMPNAGVNRLAMSLLVVKNGVYFSETEQVHFVIVIAPVDKEQHIEALYQIVHLAENHQILDDLLENVTKEKIMQTINQLVIREDE
>NC_003210.1|NP_464028.1|535427_536078_+|transaldolase
MHLDSANLDDVKKIQASSIFKGITTNPTILVKEKCNRQTAINRILELTDKQVFVQTVGFTYEEILADARMLLTMFGKDKIAIKIPAHEAGTNVIDTLKKEDKTIQILGTAIYSADQAITAALAGADFVAPYVNRMSAANIDPFKEITQMRHFFDKKALKTQIMAASFKHSGQVMQAYESGADTVTIPYEIYSQMTNKVLAVEAIRVFNEDAVLYEK
>NC_003210.1|NP_464038.1|544922_545501_+|hypothetical-protein
MKKILVPILLLATILASCSSPNEKITKDTKISKTITIRADYKVPKDIKELEDDSANIVKVKFLQNKTIGKDGSTISEIEILTSYKGNLEKGSKVDISEPWYLSDGKYVAVENYIALDKEQEYTIFLGEKDKDTYPLSSLGYGKFGGSLKEDQAVLADFNILGEVQKFDFISENTEEVKNYQLIKEQVAGKYK
>NC_003210.1|NP_464039.1|545608_546289_+|hypothetical-protein
MIIDVLQHVPHEGPGLIANWARENQHQLKIHSLFEENAHVPNDSDFLIVLGGPMGINDTAEFPWLKDERKLIKRLSEQHKPVFGVCLGAQQIAATFGSEITVNKEKEVGWFPVKRTSDKLLFFPKSLNVFHWHQDTFALPTGSTRLFASEGCLNQAFLYGENIIGLQFHFEMEKAGIETILRIDEAFITPGKYVQSVEVMREKDVPEDNKQMLEAILDYLINPKTI
>NC_003210.1|NP_464040.1|546313_546673_-|hypothetical-protein
MEQILFIQTGFGVDVHGQNITKAAERAVRNAIFTNSMPGIQGLLPDGDLQNMVVNIKLALPCDADQLDEDTIRAIIPYGTVTIEKMAGGMMTTSGIFLEDKEDKNDLMYIVNASVETGY
>NC_003210.1|NP_464041.1|546679_547138_-|hypothetical-protein
MNNEQNMNQQIALFYFGYKAFTETADLIIAKHSLKRLHHRILFFTARMPGLTINELLTFLEISKQALHQPLAELKERELLTIEQGRRDKRQRCIFLTSAGKELENELGAAQRKQMSEIFTNSADTDGMHFTEVMEGYAKNRPGAAFIKDFKE
>NC_003210.1|NP_464042.1|547519_549337_+|internalin
MKKALKLFLATICMFIMIYPSTAAHAEETNIVNIPDANLKTYLNGLLKQASDAPITKTQMNTIQTVTLSGSTYTDLTGLEEAGNLVTLSLNNTNIQTLEPIKNQTSLTYLTVGGDNVKDSLFVDLNGLVNLQSLSINGSEVTHNVFKTFNKLPKLTYLYAQNSMKITDISALASLPALTTLFLQFDGIDDFRPLNDFESFKNGNLKALAAFGQNTGRTNPRITLKSGKLDYNETNQTLYLPFSMMPKPLTSFDGTVAPFSKSTSASNTYLGFNDVALPSSRLSITDDGITVSGVTKEEFDNLDEIEYNARYDFPTGSYPTPPSMTSYTISSGTYDQYFDISHTLDLTADESFDYNQYDTTSEEQFLKDVHAETDDGTAVKSDFDQVVKLDVPGEYTVTLNAENAAGLKATPVTVKVTVHEKPVITSDSQISYKKETTKSVDEFLKEIHGSVTGNAVLTSDFDKVVDLNTPGEYTVTLNAINDRGQKADPVTVVVTVTTSDSGHVDPVPPTPQEETDQTIIPEPQSETTEDSVKEDQAKDGQAKSEEKADKTSLTTKENKVEKSEKTNQPKTKALPQTGDTNKTALPIAGVMLSLAALLIFRKSKS
>NC_003210.1|NP_464043.1|549437_549869_+|hypothetical-protein
MEKYHRILVAVDGSEPAKLAFEKGLELALKLDGVLGIASIVDLRAFSPNVSYDGSLEEKAELELKTSVNEYAEKARTAGVKQVETFVAKGNPKILLSTDIPAEFQADLIICGATGMNRVEKLVLGSVSSYIMAHAICDTLIAR
>NC_003210.1|NP_464044.1|549915_551346_-|encapsulation-protein-CapA
MKKLTYVIITGLVLVFIAGAFWITNSTNQSDQKATQTEPIKKISPANVKTISSEAKKTLNSLASSGADKASISDLKQLIKELKSYPTEKNDSGVYLQNLTACLEAVKSYTTGKADEKTLGKVYPAFLASEQKLSAIEKTNQYDWFYAAAATNQQGLKEKGVVTLTMVGDNSFGTYPETPEHLKFDNVFQKNNGNNTYVYKNCLPWFKSDDYTIINAESAFTNATKAENKMWRIKSDPAHVAFLPASGVDAANLANNHTMDYFQVGYDDTLKAFKENNIPVFNADAPLETTIKGMKTVLLGYDCRMSQQSPAYLERIVKDVKKYKKEDTLVIVNMHWGVEYRETPTDYQTQFGHAILDAGADIIMGSHPHRLESVEKYKDKYIVYSMGDFAFGADPTLLSRMTSMFQLRFTKEDNKIVLKDISIVPTYENSDGSTTENNYQPLPVFGDDAKKIVDELNRISKPIEGGVTEYTYFDPF
>NC_003210.1|NP_464045.1|551466_552282_-|phosphoglycerate-mutase
MKKNIFKLLMALCAVLLIAGCGNSTSADKKETKETKEDGTVTFYVVRHGKTMLNTTDRVQGWSDAVLTPAGEEVVKSAGKGLKDVDFSAAYSSDSGRAIQTANLILKESDKSADKEVQTDPRFREFNFGSYEGDLNENMWTDIAKSQGKTLEEWQKAGLSPKDFANSVAALDKTRVKEGENWPAEDYATIQARLKEGLTDVAKKESKNGDSNVLLVSHGLSIGALLDTIEPGYKLPAEGIKNASVTKITYKDGKFTIGDVNDLSYVEKGSK
>NC_003210.1|NP_464046.1|552562_552931_-|hypothetical-protein
MAILAFILTFIVMIEHIYIMILEMFFANTKLAAKTFGVEKELLANKKVQTLFANQGLYNGFLAAGLVWGLFFAGAGFAETVQIFFLSCVVVAALFGGATSSKGILVKQGLPAVLALVAVLLV
>NC_003210.1|NP_464047.1|553077_554493_+|multidrug-resistance-protein
MQQEATGGQKIRPIPIIASFLMAGFIGLFSETALNMALSDLIQVFDISSATVQWLTTGYLLTLGILVPISGLLLQWFTTRGLFFTAVSFSIAGTLIAALSPTFAMLMIGRVVQAVGTALLLPLMFNTILLIFPEHKRGSAMGMIGLVIMFAPAVGPTISGLILENLTWNWIFWISLPFLIIALLFGMKFMQNVSVVTKPKIDILSIILSTLGFGGVVFAFSSAGESGWGSATVLVSIIVGGIALGLFVWRQLTMEKPLMDLKVFKYPMFTLGLILVFISFMMILSTMILLPLYLQNSLALAAFSAGLVLLPGGVLNGLMSPFTGRLFDAYGPRALVIPGFIVAVVALFFLTRIEVGTSALTIIVLHSVLMIGISMVMMPAQTNGLNQLPPKLYPDGTAIMNTLQQVSGAIGTAVAITIMSAGQKAYMETAQGVGPEQMVASLTAGIQNAFVFGLIMACIGLLCSLFIRKAK

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Crispr_ID: NC_003210_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_003210_4

1136613-1136692

Orphan

Consensus_repeat	Method
AAACATTCAAGTGTTTGTTTGAATA	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NC_003210_4

>merge|NC_003210|4|1136613-1136692|CRISPRCasFinder
AAACATTCAAGTGTTTGTTTGAATATTTACAAATACATAATATCAGATTATATAAAAACATTCAAGCGTTTGTTTGAATA

>NC_003210|4|3|1136613-1136692|CRISPRCasFinder
AAACATTCAAGTGTTTGTTTGAATA	TTTACAAATACATAATATCAGATTATATAA
AAACATTCAAGCGTTTGTTTGAATA

Protein	Signature genes	Signature genes Name	Protein_function
NC_003210.1\|NP_464632.1\|1144532_1144928_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372239
NC_003210.1\|NP_464617.1\|1126703_1128194_+\|nicotinate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|236426
NC_003210.1\|NP_464634.1\|1145722_1145944_-\|hypothetical-protein	unknown	unknown	unknown
NC_003210.1\|NP_464630.1\|1139939_1142099_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|279788
NC_003210.1\|NP_464620.1\|1129411_1129816_+\|PTS-cellbiose-transporter-subunit-IIB	unknown	unknown	gnl\|CDD\|224357
NC_003210.1\|NP_464623.1\|1133465_1133696_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378900
NC_003210.1\|NP_464631.1\|1142098_1144549_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|315512
NC_003210.1\|NP_464628.1\|1137996_1138914_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372237
NC_003210.1\|NP_464635.1\|1145940_1146231_-\|hypothetical-protein	unknown	unknown	unknown
NC_003210.1\|NP_464624.1\|1133697_1134117_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274376
NC_003210.1\|YP_008475635.1\|1132786_1132987_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|371495
NC_003210.1\|NP_464625.1\|1134471_1136595_-\|cadmium-resistance-protein	unknown	unknown	gnl\|CDD\|319845
NC_003210.1\|NP_464622.1\|1131557_1132760_-\|integrase	unknown	unknown	gnl\|CDD\|271189
NC_003210.1\|NP_464621.1\|1129944_1131501_+\|GMP-synthase	unknown	unknown	gnl\|CDD\|234614
NC_003210.1\|NP_464629.1\|1138929_1139940_-\|P60-protein	unknown	unknown	gnl\|CDD\|372680
NC_003210.1\|NP_464619.1\|1129042_1129351_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224278
NC_003210.1\|NP_464618.1\|1128205_1129030_+\|NAD-synthetase	unknown	unknown	gnl\|CDD\|234831
NC_003210.1\|NP_464627.1\|1137532_1137868_-\|cadmium-efflux-system-accessory-protein	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NC_003210.1\|NP_464633.1\|1145210_1145711_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377800
NC_003210.1\|NP_464626.1\|1136899_1137400_+\|lipoprotein-signal-peptidase	unknown	unknown	gnl\|CDD\|184825

Protein	Function_ID	Function_description	E-value
NC_003210.1\|NP_464632.1\|1144532_1144928_-\|hypothetical-protein	gnl\|CDD\|372239	pfam12648, TcpE, TcpE family. This family of proteins includes TcpE a conjugative transposon membrane protein.This family of proteins is found in bacteria. Proteins in this family are typically between 122 and 168 amino acids in length.	2.37762e-35
NC_003210.1\|NP_464617.1\|1126703_1128194_+\|nicotinate-phosphoribosyltransferase	gnl\|CDD\|236426	PRK09243, PRK09243, nicotinate phosphoribosyltransferase; Validated.	0
NC_003210.1\|NP_464630.1\|1139939_1142099_-\|hypothetical-protein	gnl\|CDD\|279788	pfam01490, Aa_trans, Transmembrane amino acid transporter protein. This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.	1.31075e-05
NC_003210.1\|NP_464620.1\|1129411_1129816_+\|PTS-cellbiose-transporter-subunit-IIB	gnl\|CDD\|224357	COG1440, CelA, Phosphotransferase system cellobiose-specific component IIB [Carbohydrate transport and metabolism].	1.61024e-31
NC_003210.1\|NP_464623.1\|1133465_1133696_-\|hypothetical-protein	gnl\|CDD\|378900	pfam12645, HTH_16, Helix-turn-helix domain. This domain appears to be a helix-turn-helix domain suggesting that this might be a transcriptional regulatory protein. Some members of this family are annotated as conjugative transposon domains.	4.63875e-23
NC_003210.1\|NP_464631.1\|1142098_1144549_-\|hypothetical-protein	gnl\|CDD\|315512	pfam12846, AAA_10, AAA-like domain. This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.	0
NC_003210.1\|NP_464628.1\|1137996_1138914_-\|hypothetical-protein	gnl\|CDD\|372237	pfam12642, TpcC, Conjugative transposon protein TcpC. This family of proteins are annotated as conjugative transposon protein TcpC. The transfer clostridial plasmid (tcp) locus is part of some conjugative antibiotic resistance and virulence plasmids. TcpC was one of five genes whose products had low-level sequence identity to Tn916 proteins, having similarity to ORF13 homologs from Tn916, Tn5397, and CW459tet. This family of proteins is found in bacteria. Proteins in this family are typically between 302 and 351 amino acids in length.	5.01302e-67
NC_003210.1\|NP_464624.1\|1133697_1134117_-\|hypothetical-protein	gnl\|CDD\|274376	TIGR02985, Sig70_bacteroi1, RNA polymerase sigma-70 factor, Bacteroides expansion family 1. This group of sigma factors are members of the sigma-70 family (TIGR02937) and are found primarily in the genus Bacteroides. This family appears to have resulted from a lineage-specific expansion as B. thetaiotaomicron VPI-5482, Bacteroides forsythus ATCC 43037, Bacteroides fragilis YCH46 and Bacteroides fragilis NCTC 9343 contain 25, 12, 24 and 23 members, respectively. There are currentlyonly two known members of this family outside of the Bacteroides, in Rhodopseudomonas and Bradyrhizobium.	3.64454e-10
NC_003210.1\|YP_008475635.1\|1132786_1132987_-\|hypothetical-protein	gnl\|CDD\|371495	pfam11372, DUF3173, Domain of unknown function (DUF3173). This family of proteins with unknown function appears to be restricted to Firmicutes. These proteins appear to be distantly related to HHH domains and are therefore likely to be DNA-binding. Genomic environment-visualisation confirms the likely function as being DNA-binding, as this short protein lies very closely between an integrase and a replication protein (http://www.microbesonline.org/).	2.31059e-24
NC_003210.1\|NP_464625.1\|1134471_1136595_-\|cadmium-resistance-protein	gnl\|CDD\|319845	cd07545, P-type_ATPase_Cd-like, P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase. CadA from gram-positive Staphylococcus aureus plasmid pI258 is required for full Cd(2+) and Zn(2+) resistance. This subfamily also includes CadA, from the gram-negative bacilli, Stenotrophomonas maltophilia D457R, which is a cadmium efflux pump acquired as part of a cluster of antibiotic and heavy metal resistance genes from gram-positive bacteria. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NC_003210.1\|NP_464622.1\|1131557_1132760_-\|integrase	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	2.43662e-48
NC_003210.1\|NP_464621.1\|1129944_1131501_+\|GMP-synthase	gnl\|CDD\|234614	PRK00074, guaA, GMP synthase; Reviewed.	0
NC_003210.1\|NP_464629.1\|1138929_1139940_-\|P60-protein	gnl\|CDD\|372680	pfam13702, Lysozyme_like, Lysozyme-like.	5.42115e-80
NC_003210.1\|NP_464619.1\|1129042_1129351_+\|hypothetical-protein	gnl\|CDD\|224278	COG1359, COG1359, Uncharacterized conserved protein [Function unknown].	4.57341e-18
NC_003210.1\|NP_464618.1\|1128205_1129030_+\|NAD-synthetase	gnl\|CDD\|234831	PRK00768, nadE, ammonia-dependent NAD(+) synthetase.	0
NC_003210.1\|NP_464627.1\|1137532_1137868_-\|cadmium-efflux-system-accessory-protein	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	5.56384e-15
NC_003210.1\|NP_464633.1\|1145210_1145711_-\|hypothetical-protein	gnl\|CDD\|377800	pfam07275, ArdA, Antirestriction protein (ArdA). This family consists of several bacterial antirestriction (ArdA) proteins. ArdA functions in bacterial conjugation to allow an unmodified plasmid to evade restriction in the recipient bacterium and yet acquire cognate modification.	1.71285e-37
NC_003210.1\|NP_464626.1\|1136899_1137400_+\|lipoprotein-signal-peptidase	gnl\|CDD\|184825	PRK14797, PRK14797, lipoprotein signal peptidase; Provisional.	1.24117e-42

>NC_003210.1|NP_464625.1|1134471_1136595_-|cadmium-resistance-protein
MSKASKQTTYRVDGMSCTNCAGKFEKNVKNLEGVTDAKVNFGAGKISVYGETSISQIEKAGAFENLRVTDEKDYSSKPAKKESFLKKNWHLVVSIIFIILAFISQNISGEDSTTTIILYVIAIVVGGFNLFKEGFANLIKLDFTMESLMTIAIIGASIIGEWAEGSIVVILFAFSEVLERYSMDKARQSIRSLMDIAPKEALIRRDDVEQMIAVSDIQIGDIMIIKPGQKIAMDGVVIKGYSAINQSAITGESIPVEKKVDDEVFAGTLNEEGLLEVKVTKHVEDTTISKIIHLVEEAQGERAPAQAFVDKFAKYYTPTIMLIALLVVVVPPLFFGGDWDTWVYQGLSLLVVGCPCSLVISTPVSIVSAIGNSAKNGVLVKGGIYLEEIGGLQAIAFDKTGTLTKGKPVVTDFIPYSEHMDEQNSLSIITALETMSQHPLASAIISKAMIDNVDYKSIEIDNFSSITGKGVKGEVNGITYYIGSSKLFESSLEKSQSISQTYQSLQKQGKTAMLFGTESNILAIIAVADEVRESSKEVIAQLHKLGIAHTIMLTGDNNDTAQFIGKEIGVSDIKAELMPEDKLTYIKELKQTYGKVAMIGDGVNDAPALAASTVGIAMGGAGTDTALETADVALMGDDLKKLPFIVNLSRKTLKIIKQNITFSLGIKLLALLLVLPGWLTLWIAIVADMGATLLVTLNGLRLMKVKK
>NC_003210.1|NP_464624.1|1133697_1134117_-|hypothetical-protein
MTTTSNYEKTIEHQFDSFCKTVVRNFARDIYDENKRRNERLISLEALSMAELSQLSIFDDYDSNYIIMASYDYDIRIEDVLIAQAIGKLTKRKQDIILLSFFLSMTNADIATLMDLAESTVHYHKTNALKELKKLMEEH
>NC_003210.1|NP_464623.1|1133465_1133696_-|hypothetical-protein
MKSTKEVLPFVVILQAVNGDVNAINQILKHFEHYIIRLSQKTLFDEYGNAYIHVEEEIKRMLETKLITAVLKFELS
>NC_003210.1|YP_008475635.1|1132786_1132987_-|hypothetical-protein
MVTVTKQDLIKLGYGNSFSADIIKKAKELMISRGHTYYQSRKLDRVPREAVEELLGIKFSNENRSD
>NC_003210.1|NP_464622.1|1131557_1132760_-|integrase
MTNDQIKKAKNGTYYFRANLGYDVKGKKIQKYRSGFKTKKEAREEYSRLLLMNPDDLNENKDKMMFEYYINEIFLPWYKTQVKLRTYENRIPTIQKHFPYFYKMAVSDIEPINVQDWQLKMTKNLKPSYVRAVQGLFSVAMDRAIVLGITTTNPSKIIGNVKKVKPKVEFWTKEEFEKVLSLIYKEDYYQNFLFISLWFLFMTGMRIGEATAIQWEDIDFETGVVSITKTLYYKSQIDYKFVEPKTKASVRHIVLDKVTLSYLADWREVQQNVVKTNFVMSYNGIPTQKHTIAHAIDRFSKMAGIHRIKIHALRHSHASLLISMGENPLIIKERLGHEDIETTLGTYGHLYPNSNFEVASKLNGIISFQPAEQNLDSSPKNQFTVNYRQNKQPNSAIKVQ
>NC_003210.1|NP_464621.1|1129944_1131501_+|GMP-synthase
MFKIMKDFTEQEKIIVLDFGSQYNQLITRRIREFGVYSELHPHTITVEEMKALNPTGIIFSGGPNSVYDEDAFRADERIFDMGIPILGICYGMQLMTTHFGGKVERAKDREYGKADIHVEKPNRLFAGLPTDQVVWMSHGDLVVEEPAGFEVTVTSKSCPIAGIADEERSLYGVQFHPEVRHSVYGNELLKNFALNVCGCKGDWTMENFSEVEIAKIQEIVGDKKVLLALSGGVDSSVVGVLIHKAIGDQLTCIFVDHGLLRKGEADQVMETLQGEFNMNIIKVDAKKRFMDKLAGVSDPEQKRKIIGNEFIYVFDDEANKLDGVEFLAQGTLYTDIIESGTATAQTIKSHHNVGGLPEDMQFKLIEPLNTLFKDEVRALGTELGMPDAIVWRQPFPGPGLGIRVLGEITEEKLEIVRDSDYILREEIKNAGLEREIWQYFTALPNIRSVGVMGDGRTYDHTVVVRAVTSIDGMTADWARIPWDVLEKISVRIVNEVDHVNRVVYDITSKPPATVEWE
>NC_003210.1|NP_464620.1|1129411_1129816_+|PTS-cellbiose-transporter-subunit-IIB
MQTLMIVCAGGATSSLMAQNVVKSATSEGMDAVLLFPDDVKYKDSFREKYSTRDLVVVMGPVGAITAGKFRDYKEQVDAVLVAPQVKYMYKTVEEVLGELNIPCANINSLDFGRMRGDKILTQGLALMNAKNSK
>NC_003210.1|NP_464619.1|1129042_1129351_+|hypothetical-protein
MKVGYGLLTAFYTHPGERDHLVKILLEAAESLEEYNTCIQYIVSESENEADTVFVSEIWVDKGHHEASLDNPAVKATIERAKPLIKEVKRIQELDILGGKGV
>NC_003210.1|NP_464618.1|1128205_1129030_+|NAD-synthetase
MEIRERILADMQVAETIDAHEEIRKSVEFLKAYLKKNTFLKSFVLGISGGQDSTLTGKLAQMAISEMRAETGDDEYRFFAVSLPYGTQLDESDRQDALNFMEPDNRLTVNIKASVDASVAALAEAGVELSDFAKGNEKARERMKVQYAIAAMHKGVVVGTDHSAEAVTGFYTKYGDGGTDINPLFRLNKRQGKALLKELGCPEHLYLKKPTADLEDNKPALPDEVALGVTYDQIDDYLEGKEVPADAAAKIENWFIKTEHKRHMAITIFDDFWK
>NC_003210.1|NP_464617.1|1126703_1128194_+|nicotinate-phosphoribosyltransferase
MTNLFQDDSLTLHTDLYQLNMMKAYFDDGLHERRSVFEVFFRDMPFDSGFVVFAGLERIIHYMQNLRFTETDIAYLHDELGFDGPFLEYLRNFKFKGNILAAKEGEFVFKTEPILQVEASLAEAQLIETALLNIVNFQTLIATKAARIRSVIDDETFAEFGTRRAQEMDAAIWGTRAAYIGGCDSTSNVRAGKIFGIPVSGTMAHAMVQAYRDELEAFRSYAKTHFDSIFLVDTYDTLKSGVPNAIKVAKEMGDKINFIGIRLDSGDMAFLSKKARQMLDEAGFTEAKIFASSDLDEHTILSLKAQKAKIDSWGVGTKLITAYDQPALGAVYKMAAIADENDILQDSIKLSSNTEKVSTPGKKKVYRIITNEDGLKAEGDYIALADESLENVDKLTMFHPVHTYIMKTVENFTARELLVPIFQNGELVYDMPSLDEIKAYKEENLALLWDEYKRTVRPEQYPVDLSVKCWKNKMRNIEKVRKSVQLHSPVELDMPF
>NC_003210.1|NP_464626.1|1136899_1137400_+|lipoprotein-signal-peptidase
MKNKTIISKQNLVLIVIMVGATLTDQLSKIWITSNLQLGESIEIIPSFFKITYAQNTGAAWSILEGQMTFFYVITLVALILLGWYFYRLKDYQIIQKIGVALMVSGTLGNFIDRLLFQYVRDSLDFHILGYNFPIFNVADVLLICGVLFIIIDEVLKSFGVSYKKM
>NC_003210.1|NP_464627.1|1137532_1137868_-|cadmium-efflux-system-accessory-protein
MNDICEITCFDEEKVQKIQTSLEDKKISDISQIFKALSEETRLTIAYALTLEKELCVCDISIIVKSTVATTSHHLKILSKAGVVQNKKIGKMVYYSLNNSLVETLIKDIVL
>NC_003210.1|NP_464628.1|1137996_1138914_-|hypothetical-protein
MKIKIERKEKPDKPKKQKKIPTIKVGTHKKLTIALWVLLIGSMSFGIYKNFTAIDMHTVHEKEIIEKQVVDTNSIESFVESFSKEYFSWQQSQDSQSNRIERLKNYLTENLQQLNTEMVRSDIPTSSIVNSFQVWSVEQSSDTEYDVLFSVGQQITESENKKNITSTYSVTVYVDEASNMVIIKNPTIDSKPQKASYEPVLSDSDGTVDANTTEEINSFLDTFFKLYPTATEKELSYYVSNQALDVINKDYVFVELVNPVYTQADNQVTAIVTVKYLDKETKVTQLSQFKIILQKNENWIIIKNN
>NC_003210.1|NP_464629.1|1138929_1139940_-|P60-protein
MKLVKYFAIFGVVFSMFFSLLLFVTIVFAEEDDTRSSREEMIQQGGLNVSAEVLAHRPMVEKYCKEFGIEEYVNYILAIMQVESGGTAEDVMQSSESLGLPPNSLSTEESIKQGCKYFSELLASAESNGCDINTVIQSYNYGGGFINYVASNGKKYSYELAESFSKDKAGGVKVDYPNPIAIPVNGGWRYNYGNQFYVLLVSQYLTPVQFDDETVQAIMNEALKYEGYPYVFGGSSPSTSFDCSGLTQWSYAVAGIQLPRVAQAQYDATQHIPLSEAKAGDLVFFHSTYDAGSYVTHVGIYVGNNQMYHAGDPIGYTNLTDSYWQAHLIGAGRIIK
>NC_003210.1|NP_464630.1|1139939_1142099_-|hypothetical-protein
MRTKEERKARKIEKKQRIKQLPIYKKIIRYVLIAIIFFVILIIMLASVGTVAHAAGLVDETINTSNEYSKYGLGNYQLDFYVNNDWGWLPWNWSDGIGKSVSYGLYAITNFVWTISLYLSNATGYLVQEAYSLDFISKTVDSIGKNIQTIAGVTKNGFSTSGFYVGFLLILIFILGIYVTYTGLIKRETTKAVRAVLNFIVVFILSASFIAYAPDYIGNINDFSKDISTSALDVGTKIVMPDTDSKGKDSVDMIRDSLFSVQVKQPWLLLQYGTTDVDSLGADRVESLLSTSPDTNNGEDREDIVITEIETFNNANLSISKTVSRLGTVFFLFIFNIGISVFVFLLTGMMIFSQVLFIIFAMFLPISFLLSMIPSFDGMGKKAIMKLFNVIMTRAGLTLVITVAFSISTMLYSLAGSSPFFMIMFLQIVTFAGIYFKLGDIMNMFSLQSNDSQSMGRQMFRKPRMFLNRQSRRLQRNVSRAIGKNSRSGKEKEAPTPTKTTKANHERQNENGNESTANRPTSTKQNRSAGTRAGEKMGDLMEAKNRMVDKAGDMKDTIKNAPTNAKYAVHKGKRDLVRNVSEFSQSFADTRNLQQQERATKRNEKKATVAQRRQEMDKAKAEKSNLEPYASMQKRQRDYEERKQPVPRTAPTPAPQASTPKATPERTASTNQQHERPLQKQKNTTKEQVKANKRENTSTTSKNSKTENKITKTTTKRRK
>NC_003210.1|NP_464631.1|1142098_1144549_-|hypothetical-protein
MAYPIKYIENNLVFNNDGECFAYYELIPYNYSFLSPDEKYQVHDNFRQLVAQSRDGKIHALQLATESSIRATQERSKLEVKGRLKEVAHRKIDEQTEALVSMIGDNQVDYRFFIGFKLLLNEQELSIQSVSQEIKKAVQEFLNGVNHKLMGDFVSMSNAEIDRFSKMENLLESKISRRFKIRKLDKNDFGYIIEHIYGQTGTPYEEYEYHLPKKYQDKEVLVKKYDILKPTRCLIDESQRYLKIIHEDETTYVAYFTINSIVGELDFPSSEIFYYQQQQFTFPIDTSMNVEIVANKKALTTVRNKKKELKDLDSHAWESDNETSNNVIDALDSVNELETTLDQSKESMYKLSYVVRVSAKDLDELKRRCDEVKDFYDDLSIKLVRPFGDMLGLHGEFIPASKRYINDYIQYVTSDFLAGLGFGATQTLGEHEGIYVGYNLDTGKNVYLKPALASQGVKGSVTNALASAFIGSLGGGKSFSNNMLVYYAVLFGGQAVIVDPKAERGKWKETLPEIAHEINIVNLTSDDENKGLLDPYVILSRKKDSESLAIDILTFLTGISSRDSDKFPVLRKAIRNVTQSEQRGLLLVIDELRKEDTSISNSIADHIESFVDYDFAHLLFSDGNVTQSISLEKQLNIIQVADLVLPDADTSFEEYTTMELLSVAMLIVISTFALDFIHTDRSIFKIVDLDEAWSFLQVAQGKTLSMKLVRAGRAMNAGVYFVTQNADDLLDEKMKNNIGLKFAFRSTDLVEIKKTLTFFGVDPEDENNQKRLRELENGQCLISDLYGRVGVMQFHPIFEELLQAFDTRPPIRNEVE
>NC_003210.1|NP_464632.1|1144532_1144928_-|hypothetical-protein
MKKIRSYTSIWNVEKVIYAINDLQLPFPITFTQMTWFIVSLLVIVMFGSLPPLSLIDGALLKYIGIPVGLAWFMSQKTFDGKKPYGFLKSILTYFIRAKTTYAGKAVKLQKQQFNEAITTVRSELYYGISN
>NC_003210.1|NP_464633.1|1145210_1145711_-|hypothetical-protein
MEEMRIYVANLGKYNEGELVGAWFTPPIDYEEMEEKIGLNGEYEEYAIHDYELPFDIDEYTPISEINRLCEMIMELDGSPIYDELKDIQGMWFSSLEELLESKDDIICYSDCDSMEDIAYYYVEDGLMGEIPERLQMYLNYQAIGRDLEINGNFLVTSHGVFEYCN
>NC_003210.1|NP_464634.1|1145722_1145944_-|hypothetical-protein
MNFGQNLYNWFLSNAQSLVLLAIVVIGLYLGFKREFSKLIGFLIIALIAVGLVFNAGGVKDVLLNLFNRIIGA
>NC_003210.1|NP_464635.1|1145940_1146231_-|hypothetical-protein
MSGLTAELYELGFNCGIELEIYIQDTGIYTSLIIEGFRKGVDEPYQYDFYKQTFYPHYPNKVTVYGEHLRPSQLIERVERYFINRKKYMSERRNNT

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Crispr_ID: NC_003210_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_003210_5

2779697-2779807

Orphan

Consensus_repeat	Method
AGCGATGATTTAATCCTTCCCAGAACTTTCAAAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_003210_5

>merge|NC_003210|5|2779697-2779807|CRISPRCasFinder
AGCGATGATTTAATCCTTCCCAGAACTTTCAAAATGTACTTTATTTTGATTTAGTTCTTCAATATAAATCTGAGCAAAGCGATGATTTAATCCTTCCCAGAACTTTCAAAA

>NC_003210|5|4|2779697-2779807|CRISPRCasFinder
AGCGATGATTTAATCCTTCCCAGAACTTTCAAAA	TGTACTTTATTTTGATTTAGTTCTTCAATATAAATCTGAGCAA
AGCGATGATTTAATCCTTCCCAGAACTTTCAAAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_003210.1\|NP_466221.1\|2774683_2775523_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|319818
NC_003210.1\|NP_466229.1\|2780576_2780798_-\|hypothetical-protein	unknown	unknown	unknown
NC_003210.1\|NP_466225.1\|2777496_2777814_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|234669
NC_003210.1\|NP_466217.1\|2771622_2772612_+\|dihydroxyacetone-kinase-subunit-DhaK	unknown	unknown	gnl\|CDD\|237724
NC_003210.1\|NP_466231.1\|2782738_2782894_+\|hypothetical-protein	unknown	unknown	unknown
NC_003210.1\|NP_466235.1\|2786434_2787373_-\|internalin	unknown	unknown	gnl\|CDD\|226309
NC_003210.1\|NP_466232.1\|2783465_2784107_-\|hypothetical-protein	unknown	unknown	unknown
NC_003210.1\|NP_466219.1\|2773233_2773608_+\|PTS-mannose-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|184702
NC_003210.1\|NP_466228.1\|2780391_2780574_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|371501
NC_003210.1\|NP_466233.1\|2784353_2784674_+\|hypothetical-protein	unknown	unknown	unknown
NC_003210.1\|NP_466234.1\|2784804_2786319_-\|gluconate-kinase	unknown	unknown	gnl\|CDD\|212659
NC_003210.1\|NP_466226.1\|2777843_2779583_-\|DNA-polymerase-III-subunit-gamma/tau	unknown	unknown	gnl\|CDD\|235505
NC_003210.1\|NP_466222.1\|2775643_2776486_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|223729
NC_003210.1\|NP_466236.1\|2787415_2788363_-\|pepdidoglycan-bound-protein	unknown	unknown	gnl\|CDD\|273478
NC_003210.1\|NP_466227.1\|2779909_2780374_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378692
NC_003210.1\|NP_466230.1\|2780932_2782297_-\|PTS-cellbiose-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|224372
NC_003210.1\|NP_466224.1\|2776791_2777388_-\|recombination-protein-RecR	unknown	unknown	gnl\|CDD\|234616
NC_003210.1\|NP_466223.1\|2776531_2776777_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378478
NC_003210.1\|NP_466220.1\|2773713_2774565_+\|RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224651
NC_003210.1\|NP_466218.1\|2772633_2773230_+\|dihydroxyacetone-kinase	unknown	unknown	gnl\|CDD\|274099

Protein	Function_ID	Function_description	E-value
NC_003210.1\|NP_466221.1\|2774683_2775523_+\|hypothetical-protein	gnl\|CDD\|319818	cd07516, HAD_Pase, phosphatase, similar to Escherichia coli Cof and Thermotoga maritima TM0651; belongs to the haloacid dehalogenase-like superfamily. Escherichia coli Cof is involved in the hydrolysis of HMP-PP (4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate, an intermediate in thiamin biosynthesis), Cof also has phosphatase activity against the coenzymes pyridoxal phosphate (PLP) and FMN. Thermotoga maritima TM0651 acts as a phosphatase with a phosphorylated carbohydrate molecule as a possible substrate. Escherichia coli YbhA is also a member of this family and catalyzes the dephosphorylation of PLP, YbhA can also hydrolyze erythrose-4-phosphate and fructose-1,6-bis-phosphate. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.49073e-86
NC_003210.1\|NP_466225.1\|2777496_2777814_-\|hypothetical-protein	gnl\|CDD\|234669	PRK00153, PRK00153, YbaB/EbfC family nucleoid-associated protein.	3.53269e-41
NC_003210.1\|NP_466217.1\|2771622_2772612_+\|dihydroxyacetone-kinase-subunit-DhaK	gnl\|CDD\|237724	PRK14481, PRK14481, dihydroxyacetone kinase subunit DhaK; Provisional.	0
NC_003210.1\|NP_466235.1\|2786434_2787373_-\|internalin	gnl\|CDD\|226309	COG3786, COG3786, Uncharacterized protein conserved in bacteria [Function unknown].	3.04876e-98
NC_003210.1\|NP_466219.1\|2773233_2773608_+\|PTS-mannose-transporter-subunit-IIA	gnl\|CDD\|184702	PRK14484, PRK14484, phosphotransferase mannnose-specific family component IIA; Provisional.	1.1917e-48
NC_003210.1\|NP_466228.1\|2780391_2780574_-\|hypothetical-protein	gnl\|CDD\|371501	pfam11384, DUF3188, Protein of unknown function (DUF3188). This bacterial family of proteins has no known function.	1.21027e-11
NC_003210.1\|NP_466234.1\|2784804_2786319_-\|gluconate-kinase	gnl\|CDD\|212659	cd07770, FGGY_GntK, Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases. This subfamily is composed of a group of gluconate kinases (GntK, also known as gluconokinase; EC 2.7.1.12) encoded by the gntK gene, which catalyzes the ATP-dependent phosphorylation of D-gluconate and produce 6-phospho-D-gluconate and ADP. The presence of Mg2+ might be required for catalytic activity. The prototypical member of this subfamily is GntK from Lactobacillus acidophilus. Unlike Escherichia coli GntK, which belongs to the superfamily of P-loop containing nucleoside triphosphate hydrolases, members in this subfamily are homologous to glycerol kinase, xylulose kinase, and rhamnulokinase from Escherichia coli. They have been classified as members of the FGGY family of carbohydrate kinases, which contain two large domains separated by a deep cleft that forms the active site. This model spans both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. Some uncharacterized homologous sequences are also included in this subfamily. The Lactobacillus gnt operon contains a single gntK gene. The gnt operons of some bacteria, such as Corynebacterium glutamicum, have two gntK genes. For example, the C. glutamicum gnt operon has both a gluconate kinase gntV gene (also known as gntK) and a second hypothetical gntK gene (also known as gntK2). Both gluconate kinases encoded by these genes belong to this family, however the protein encoded by C. glutamicum gntV is not included in this model as it is truncated in the C-terminal domain.	0
NC_003210.1\|NP_466226.1\|2777843_2779583_-\|DNA-polymerase-III-subunit-gamma/tau	gnl\|CDD\|235505	PRK05563, PRK05563, DNA polymerase III subunits gamma and tau; Validated.	0
NC_003210.1\|NP_466222.1\|2775643_2776486_+\|aldo/keto-reductase	gnl\|CDD\|223729	COG0656, ARA1, Aldo/keto reductases, related to diketogulonate reductase [General function prediction only].	6.97706e-130
NC_003210.1\|NP_466236.1\|2787415_2788363_-\|pepdidoglycan-bound-protein	gnl\|CDD\|273478	TIGR01167, Zinc_metalloprotease_ZmpB, LPXTG-motif cell wall anchor domain. This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region. [Cell envelope, Other].	1.13667e-05
NC_003210.1\|NP_466227.1\|2779909_2780374_-\|hypothetical-protein	gnl\|CDD\|378692	pfam11687, DUF3284, Domain of unknown function (DUF3284). This family of proteins with unknown function appears to be restricted to Firmicutes.	5.35099e-31
NC_003210.1\|NP_466230.1\|2780932_2782297_-\|PTS-cellbiose-transporter-subunit-IIC	gnl\|CDD\|224372	COG1455, CelB, Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism].	3.47828e-162
NC_003210.1\|NP_466224.1\|2776791_2777388_-\|recombination-protein-RecR	gnl\|CDD\|234616	PRK00076, recR, recombination protein RecR; Reviewed.	7.77001e-132
NC_003210.1\|NP_466223.1\|2776531_2776777_-\|hypothetical-protein	gnl\|CDD\|378478	pfam10704, DUF2508, Protein of unknown function (DUF2508). This family is conserved in Firmicutes. Several members are annotated as being the protein YaaL. The function is not known.	2.68189e-15
NC_003210.1\|NP_466220.1\|2773713_2774565_+\|RpiR-family-transcriptional-regulator	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	6.1079e-63
NC_003210.1\|NP_466218.1\|2772633_2773230_+\|dihydroxyacetone-kinase	gnl\|CDD\|274099	TIGR02365, dha_L_ycgS, dihydroxyacetone kinase, phosphoprotein-dependent, L subunit. Two types of dihydroxyacetone kinase (glycerone kinase) are described. In yeast and a few bacteria, e.g. Citrobacter freundii, the enzyme is a single chain that uses ATP as phosphoryl donor and is designated EC 2.7.1.29. By contract, E. coli and many other bacterial species have a multisubunit form (EC 2.7.1.-) with a phosphoprotein donor related to PTS transport proteins. This family represents the subunit homologous to the E. coli YcgS subunit.	3.29756e-82

>NC_003210.1|NP_466226.1|2777843_2779583_-|DNA-polymerase-III-subunit-gamma/tau
MAYQALYRVFRPQSFQDVVGQEHVTKTLKNAIVQNKTSHAYLFSGPRGTGKTSAAKIFAKAINCEHGHDGEPCNECEICKGTTDGSIPDVLEIDAASNNGVEEIRDIREKVKYAPTVAKYKVYIIDEVHMLSTGAFNALLKTLEEPPKHVIFILATTEPHKLPLTIISRVQRFDFKRITTQDIIGRLKFILEEEKIPYDEKALMIVARAAEGGMRDALSLLDQVISYGSEEVTVEDALEITGSVAQNLLTKLVSAAFDGDAAEAISTLTALLAEGKDPVRLVEDLLVFFRDVLLYQKAPNLEETMERALIDDDFVALAKRADSLKVYEFVKILNTAQQQMRFSNHPGIYVEVALVQLTQAGQSVAGGGNVPADAASGSDVSDLKRQMEQMHQEIQTLKKQIASGAGAAPADKPTQNRGGSKKAINNGKQFKAPIGKINHVLGEAKKENLQLIRGCWGELLSMLMASQAALLNDAEPVAASQDTFVLKFKHEIHCQMAMDNPNFVETITSSIARLTQVNYTFIGIPEDQWADVRENFLHSHGSDADAEDGANPEAKKPAEDPFVAEAAKLVGEDLLEIKD
>NC_003210.1|NP_466225.1|2777496_2777814_-|hypothetical-protein
MRGMGNMQGMMKQMQKMQKEMAKAQADLEAQEFTGTAGGGMVTVKATGKRVITDVVINEEVVDPEDIEMLQDLVLAATNDVLKQIEDTTSQTMGKFTQGLNIPGM
>NC_003210.1|NP_466224.1|2776791_2777388_-|recombination-protein-RecR
MHYPEPITKLIDSFMKLPGIGPKSAARLAFYVLDMKEDDVLDFAKALVDAKRNLSFCSVCGHITDKDPCYICADTSRDRSVICVVQESKDVIAMEKMRDFHGLYHVLHGTISPMDGIGPEDINIPDLLKRLQDDTIEEVILATNPNVEGEATAMYISRLLKPSGIKVTRIAHGLPVGGDLEYADEVTLSKAMEGRREV
>NC_003210.1|NP_466223.1|2776531_2776777_-|hypothetical-protein
MESRSNKFGRKKNKKIGKLHKSYDAYLMELIEVTQENWHKQKVLMRKSFEYDPNLEYEEKKAEARYFYLFKEARTRQLKNK
>NC_003210.1|NP_466222.1|2775643_2776486_+|aldo/keto-reductase
MTLSFSDTYRLNNGIEMPRHGFGVYKLTDEARMRTALETAVDVGYRLFDTASFYHNEKELGDFFASSGLKRDEFFVTTKMWNTEQGYDETLRAFEKSQKKLQLDQIDLYLVHWPKQDTFFDTWRAVEKLYDEGLVRAIGVSNFEAHHLDRLRTSANVLPVVDQLETHPHFPNHLLHRYLEELHIVHQAWSPLGRGGVLQEQILIDLAEKHGKSPAQIVLRWHLQNNISIIPKSETPSRIRENAAIYDFELSEADMRQVERLNTGERVSHAPDVMYVRSEI
>NC_003210.1|NP_466221.1|2774683_2775523_+|hypothetical-protein
MTTQAIILDIDGTLLNDDKQISPETKKALITAQENGVKLILASGRPTTGMHVYAEQLEMEKHHGLLVSYNGAKVVDCATNEELFNQALTVEEGKAVLEHMKQFEVKVMIDKEDYMYTNDVYDCYVPYRGEEINIIQYESRGGNFKLCEKDDLAAFLDYRLSKILTAGDPAYMQKNYQAMMAPFKDTLNCVFTADFYFEFTAQGIDKAKALDTVLTPMGIHAENVIAFGDGHNDITMVEYAGTGIAMQNAVPELKAAASSVTLSNNEDGIAHVLNSLIPS
>NC_003210.1|NP_466220.1|2773713_2774565_+|RpiR-family-transcriptional-regulator
MNILIKIRELTNLTNSEKELANYILANPKKTLQFKPKELATAAFVSAATIYRLINKLGLNGIGELKIEIASSLRETSEEKDLNYDYPILESDTPYQIMTNLHQIYKGTIDETLNNADPEELVKIGEKLIQAKTIDVYAASANLFFAQNFKFQMQEIGVLVNVPEEDYIQSLSAANSDENHIAIVVSYGGRSRTLQRVVKILSENNVDIILITSMQDNPLVEFATHKIYMASAENHYNKVSSFSTRQSLLSIFDTLYSIYFNQNYEKNIQYKTTNYQKMNTELE
>NC_003210.1|NP_466219.1|2773233_2773608_+|PTS-mannose-transporter-subunit-IIA
MAKPYGVVIISHSKDVAKGVHDIIKEIAPDVSITHAGGTEDGRIGTSFDAVNEAIENNEANKVYTFYDLGSAKMNIETVEEISEKEIILFNAPILEGAYATAAQVQMDEKPEVIAANLKTIEIK
>NC_003210.1|NP_466218.1|2772633_2773230_+|dihydroxyacetone-kinase
MTYDKDWALRWLNDFGERVQENKQLLSDLDQAIGDGDHGINMARGLGELKKAFTEKEPADLKDVFKTAGMTMVSKVGGASGPLYGTAFLNMSKAVDADTIDAVGLTKVIEAGLEGIEKRGKSHAGEKTMIDVWEPVVHALHQEDLTDDVVDAALQKTKDLKATKGRASYLGERSIGHLDPGAYSSALLFHAMLQTEVS
>NC_003210.1|NP_466217.1|2771622_2772612_+|dihydroxyacetone-kinase-subunit-DhaK
MKKILNGTDQVVEQMVEGLVKSHADVVHRVEGTRVIARNDKRPGKVGLVSGGGSGHEPAHAGYVGRGMLSAAVCGDVFTSPTPDQIYEGIKAADQGAGVLLIVKNYTGDVMNFEMAADLADADDIKVEQIVVDDDIAVEDSTFTTGRRGVAGTVLVHKIIGAAAEAGASLDELKALGEKVIASVKTLGVALSPCTVPEVGHPGFELGDDEIELGIGIHGEPGFTREKIMPSASLAKQLYERISNESKLLAGDKVVVLVNGMGATPLMEQYVFANDVHELLKNAGVQVEKTLVGDYMTSLEMAGLSLTILKLEDEKWVDMLKLPVDTIAW
>NC_003210.1|NP_466227.1|2779909_2780374_-|hypothetical-protein
MNVTQKLYISQKECFDTLVSSAIYDVKNATGKTLQVRKLEGYKYQRTMSNGALATTKIVKVQPNELYQFETSSRVNTHTTTYTIKSTSETTCEVTYNELIETEKALNKMNNIIVGFMFGFFRKKRVKNLLKSIELSVINESKQKQEKLAAKSEQ
>NC_003210.1|NP_466228.1|2780391_2780574_-|hypothetical-protein
MKIVNALFLISIGLIIIMFSPSYGKDGMASVPLLVTGLAVVLIGCVFIVLKIRKDKKEKN
>NC_003210.1|NP_466229.1|2780576_2780798_-|hypothetical-protein
MIILNCPMKRDYITELLETYDKDGVTFKKIDEKGMKLTFETNIEDEEKAAKIAKETIKATEIGSVLYFQVSVG
>NC_003210.1|NP_466230.1|2780932_2782297_-|PTS-cellbiose-transporter-subunit-IIC
MNGLTAFLEKYFVPVAAKIGSQKHLVALRDAFISTMPITMAGSIAVLLNAFFRDFPTDWGWTGFVEAMQPLIGINGYVYNGTLAIVSIIFAFSLGYNLSKAYEVDRLAGGLVSLAAFVMNLTVTVSLDAVKAAIAASNANFDVATLPKEFAGIYGFFSLSQVNGTGLFTAMIFGFISTIIYAKLMRRNIIIKMPDSVPPAVSKAFAAIIPALVALYVVGIIDWAFFKITNMDVITWISKTIQEPLLSLSQGYGAVLLVTFLVQLLWFFGIHGPNVLAPVLESLWGTAQLQNISAAQEGAKLPFEWVRGSFDAYVWMGGSGGTLVLIIALLMFSKRADARTVAKLSLAPGIFNINEPIMFGLPIVLNTIYLIPFLIAPMVMVTIAYFATTLGIVGPVKIAVVWVMPPLLNSFLATGGDWMAPVISLINMVVAFLIWVPFVITANRVGVPEEEMKA
>NC_003210.1|NP_466231.1|2782738_2782894_+|hypothetical-protein
MAVKRDMPEESKNSKVVKKEHFSIVFPDDIKEPATVEEKKKQDAEKKTDDN
>NC_003210.1|NP_466232.1|2783465_2784107_-|hypothetical-protein
MQQLKSKKKWLPALIVAVFVGIIVILAIMFGFFQRQEVFDKYEVAYEIDGKLYEVFPISATDIGVDKKSKDKNLYFRVNSYYNIDYLFRLAYKQYEINEPSTNKYYSGLIDYSVADNAYVTQKDVYITNNESYATYDFFDKNGKKIYTYNPEETSNDDYIVRIKPTILQGYEKSDIGSYDDYLNITALFKDKLGMDVNVRIDEDKEMVIFSIK
>NC_003210.1|NP_466233.1|2784353_2784674_+|hypothetical-protein
MLLPSGPDMVHRFPLRKTQPSTPLVKGRPNNYDASNEEFNPARADCGLQGAATSPSSTTNLLPIIKCQIKNYLAQTLKRAQLLVYLFHLKSASGNTEIFFNVSKHS
>NC_003210.1|NP_466234.1|2784804_2786319_-|gluconate-kinase
MTSKPYIMGVDIGTSSTKAVLFNQRGEVIFRQATHYELITDETGKAEESPTEIFDAVLTSIQAVMKNINTEELAGISFSSAMHSLIMVGSNGELLTECITWADGRSSETLEKVKRDNYLFQLYEATGTPIHPMSPFAKICWLKEEKPTLFKRTEKFVDIKSYILYRLFGVWVMDESLASGTGLYNIMEHDWEFEAMEIVKLTPDFLPKVVPETYQLAGVKKEYAELMGIPENLPFIIGGSDGALANIGIQATGQNDVTITVGTSGAVRKLTDQFQIDSRGRTFCYGAGDGYFIAGGAVNNGGKVVEWGLQQFGSEAEISRRDFASFIAKIEEVPPGAAGLLFQPYLLGERAPFWTNDIRGGFVGLTINHTKAHFIRAILEGVAFNLAEVYEAVSAPDDIIYVTGGISAHDAWCKLLADILNREIRVPHTIEGSSLGAAIIGMRSLGILKDLNLKHTLPIKAVYHPSENVLKYAELRLIFKQVTTQLMSSYSQLNSWQKKFDINS
>NC_003210.1|NP_466235.1|2786434_2787373_-|internalin
MKKLLSGLIVVLMVSLLGHSFNAEAASYEKIIYDKAVNLKGVVNQSKRNDGINSKMYKTSSSVKYLGSAKKYDKKTLIITREGKTARAKWYYCKLGNTTIGWIDSRAFTNIGKPTIADAVPALWNSKKAIITTKPKSTTATTYFFQKNSAGNWYEVRHFTSHIGKWGFDPKFSEKSSGTPVGVYRTGIAFGQKGNPGTKLTFRAITNRSYWISNSNDKAYNTWQERNSSSSADEKMKIPQYKYGMEVKYNAKRVKGKGSAVFYHVDSPKYNYTLGCVAQSEANTKEVLKFADKNTLIVLGEESRIKTFYGIN
>NC_003210.1|NP_466236.1|2787415_2788363_-|pepdidoglycan-bound-protein
MKKFHGLILTALVTCLIIPFSLAASAETNENGNNSTPTEEKTTDTTENIITEEKTEPAEPTKDTTVTPPQKSKVQTTIDITDSQEVYSYEQNSKIDLKDFTATLTDYTDTKLTNYRLAANSKLSTAQTGIQEVTLLGDNEDGKTTAVKLNYLVKEKTAQLTITDMNFDLETKIFTGKTKPFASVYMSSPADENFGEGTTTADKDGYFYAEWATTPKQITAYAFDESGNYSEEVTYQVPAKKQNEAVVTAPDKVKKIETKNAVKSATTKPTDVTKVTKDDKTDLPSTGDKGTEWIFVVAGVIVILVAVLLLRKRKK

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_003210_3	3.3\|544534\|35\|NC_003210\|PILER-CR,CRISPRCasFinder,CRT	544534-544568	35	MH341453	Listeria phage PSU-VKH-LP041, complete genome	10139-10173	1	0.971
NC_003210_3	3.3\|544534\|35\|NC_003210\|PILER-CR,CRISPRCasFinder,CRT	544534-544568	35	NC_009813	Listeria phage B054, complete genome	10139-10173	2	0.943
NC_003210_4	4.1\|1136638\|30\|NC_003210\|CRISPRCasFinder	1136638-1136667	30	LC492751	Staphylococcus phage KSAP7 genomic DNA, compelete genome	2378-2407	7	0.767
NC_003210_4	4.1\|1136638\|30\|NC_003210\|CRISPRCasFinder	1136638-1136667	30	LC492752	Staphylococcus phage KSAP11 genomic DNA, compelete genome	2378-2407	7	0.767

1. spacer 3.3|544534|35|NC_003210|PILER-CR,CRISPRCasFinder,CRT matches to MH341453 (Listeria phage PSU-VKH-LP041, complete genome) position: , mismatch: 1, identity: 0.971

gcgatttttgtcaaagggacagcgatgggttacaa	CRISPR spacer
gcgatttttgtcaaaggaacagcgatgggttacaa	Protospacer
*****************.*****************

2. spacer 3.3|544534|35|NC_003210|PILER-CR,CRISPRCasFinder,CRT matches to NC_009813 (Listeria phage B054, complete genome) position: , mismatch: 2, identity: 0.943

gcgatttttgtcaaagggacagcgatgggttacaa	CRISPR spacer
gcgatttttgtcaaaggaacggcgatgggttacaa	Protospacer
*****************.**.**************

3. spacer 4.1|1136638|30|NC_003210|CRISPRCasFinder matches to LC492751 (Staphylococcus phage KSAP7 genomic DNA, compelete genome) position: , mismatch: 7, identity: 0.767

tttacaaatacataatatcagattatataa	CRISPR spacer
cttacaaatacattatatcatattcttttt	Protospacer
.************ ****** *** * *

4. spacer 4.1|1136638|30|NC_003210|CRISPRCasFinder matches to LC492752 (Staphylococcus phage KSAP11 genomic DNA, compelete genome) position: , mismatch: 7, identity: 0.767

tttacaaatacataatatcagattatataa	CRISPR spacer
cttacaaatacattatatcatattcttttt	Protospacer
.************ ****** *** * *

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

120653 : 127178

Listeria_phage(33.33%)

tail

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
NP_463646.1\|120653_121106_-	hypothetical protein	A0A059T7S0	Listeria_phage	4.0e-31	47.9
NP_463647.1\|121111_121447_-	repressor C1	A0A2H4JAR9	uncultured_Caudovirales_phage	4.0e-20	52.5
NP_463648.1\|121663_122092_+	hypothetical protein	NA	NA	NA	NA
NP_463649.1\|122103_122520_+	hypothetical protein	A8ASQ1	Listeria_phage	1.3e-20	39.3
NP_463650.1\|122797_123187_+	antigen B	NA	NA	NA	NA
NP_463651.1\|123199_123712_+	antigen A	A0A097PBF4	Streptococcus_pyogenes_phage	1.2e-47	62.7
NP_463652.1\|123759_124062_+	hypothetical protein	NA	NA	NA	NA
NP_463653.1\|124103_124508_+	hypothetical protein	NA	NA	NA	NA
NP_463654.1\|124494_126363_+\|tail	phage tail protein	A0A097PAU2	Streptococcus_pyogenes_phage	3.5e-20	45.8
NP_463655.1\|126359_127178_+	hypothetical protein	A0A060AFE1	Staphylococcus_phage	7.2e-39	35.0

DBSCAN-SWA_2

1124078 : 1149720

Streptococcus_phage(66.67%)

integrase

attL 1129850:1129865|attR 1153642:1153657

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
NP_464614.1\|1124078_1124462_+	glycerol-3-phosphate cytidylyltransferase	A0A1V0SGE7	Hokovirus	1.4e-16	40.7
NP_464615.1\|1124483_1125467_+	glycosyltransferase	A0A1V0SAH6	Catovirus	4.1e-12	34.6
NP_464616.1\|1125481_1126495_+	glysosyltransferase	A0A1V0SAH6	Catovirus	7.9e-11	32.0
NP_464617.1\|1126703_1128194_+	nicotinate phosphoribosyltransferase	G3MA18	Bacillus_virus	9.5e-114	49.7
NP_464618.1\|1128205_1129030_+	NAD synthetase	G3MA24	Bacillus_virus	7.4e-68	52.6
NP_464619.1\|1129042_1129351_+	hypothetical protein	NA	NA	NA	NA
NP_464620.1\|1129411_1129816_+	PTS cellbiose transporter subunit IIB	NA	NA	NA	NA
1129850:1129865	attL	NA	NA	NA	NA
NP_464621.1\|1129944_1131501_+	GMP synthase	A0A1V0SH76	Hokovirus	2.3e-17	28.1
NP_464622.1\|1131557_1132760_-\|integrase	integrase	A0A0S2MV79	Bacillus_phage	2.7e-42	32.8
YP_008475635.1\|1132786_1132987_-	hypothetical protein	NA	NA	NA	NA
NP_464623.1\|1133465_1133696_-	hypothetical protein	NA	NA	NA	NA
NP_464624.1\|1133697_1134117_-	hypothetical protein	A0A1S5SEW0	Streptococcus_phage	2.9e-12	31.3
NP_464625.1\|1134471_1136595_-	cadmium resistance protein	E4ZFI9	Streptococcus_phage	2.9e-241	63.3
NP_464626.1\|1136899_1137400_+	lipoprotein signal peptidase	NA	NA	NA	NA
NP_464627.1\|1137532_1137868_-	cadmium efflux system accessory protein	E4ZFI8	Streptococcus_phage	3.4e-19	47.1
NP_464628.1\|1137996_1138914_-	hypothetical protein	A0A1S5SF22	Streptococcus_phage	5.7e-85	58.0
NP_464629.1\|1138929_1139940_-	P60 protein	A0A1S5SEZ8	Streptococcus_phage	2.4e-140	74.8
NP_464630.1\|1139939_1142099_-	hypothetical protein	A0A1S5SF30	Streptococcus_phage	3.2e-195	64.9
NP_464631.1\|1142098_1144549_-	hypothetical protein	A0A1S5SF64	Streptococcus_phage	0.0e+00	82.1
NP_464632.1\|1144532_1144928_-	hypothetical protein	A0A1S5SEX7	Streptococcus_phage	7.0e-48	71.0
NP_464633.1\|1145210_1145711_-	hypothetical protein	A0A1S5SF25	Streptococcus_phage	2.4e-53	61.6
NP_464634.1\|1145722_1145944_-	hypothetical protein	A0A1S5SEY0	Streptococcus_phage	8.1e-30	94.5
NP_464635.1\|1145940_1146231_-	hypothetical protein	NA	NA	NA	NA
NP_464636.1\|1146227_1147412_-	hypothetical protein	A0A1S5SEX3	Streptococcus_phage	5.2e-155	65.7
NP_464637.1\|1147602_1149003_-	hypothetical protein	A0A1S5SFB5	Streptococcus_phage	2.1e-179	67.4
NP_464638.1\|1149010_1149385_-	hypothetical protein	A0A1S5SF96	Streptococcus_phage	9.6e-39	65.4
NP_464639.1\|1149405_1149720_-	hypothetical protein	A0A1S5SF38	Streptococcus_phage	1.1e-43	81.6
1153642:1153657	attR	NA	NA	NA	NA

DBSCAN-SWA_3

1838050 : 1846336

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
NP_465291.1\|1838050_1838617_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	7.0e-25	35.9
NP_465292.1\|1838613_1839663_-	phosphoribosylaminoimidazole synthetase	Q58MH8	Prochlorococcus_phage	1.0e-61	43.2
NP_465293.1\|1839681_1841109_-	amidophosphoribosyltransferase	A0A1B1ISH6	uncultured_Mediterranean_phage	8.1e-54	31.9
NP_465294.1\|1841093_1843313_-	phosphoribosylformylglycinamidine synthase II	A6N228	Microbacterium_phage	2.0e-160	41.2
NP_465295.1\|1843305_1843989_-	phosphoribosylformylglycinamidine synthase I	NA	NA	NA	NA
NP_465296.1\|1843992_1844238_-	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
NP_465297.1\|1844249_1844963_-	phosphoribosylaminoimidazole-succinocarboxamide synthase	A0A0E3F9V5	Synechococcus_phage	2.3e-41	38.3
NP_465298.1\|1845043_1846336_-	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	7.2e-17	32.6

DBSCAN-SWA_4

2360907 : 2403235

Listeria_phage(96.61%)

coat,integrase,terminase,holin,tail,portal

attL 2357501:2357516|attR 2411019:2411034

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2357501:2357516	attL	NA	NA	NA	NA
NP_465795.1\|2360907_2361141_-	hypothetical protein	A0A059T6E1	Listeria_phage	8.9e-35	93.5
NP_465796.1\|2361581_2361791_+	hypothetical protein	A0A059T7Z0	Listeria_phage	1.9e-28	98.6
NP_465797.1\|2361896_2362274_+	hypothetical protein	Q9T194	Listeria_phage	2.6e-60	89.6
NP_465798.1\|2362305_2362656_+	protein gp29	Q9T195	Listeria_phage	7.5e-54	93.1
NP_465799.1\|2362660_2363110_+	protein gp28	A8ATW7	Listeria_phage	6.5e-74	97.3
NP_465800.1\|2363134_2363632_+	hypothetical protein	A8ATW6	Listeria_phage	1.8e-88	97.6
NP_465801.1\|2363708_2364260_-	hypothetical protein	A8ASL6	Listeria_phage	7.4e-96	95.6
NP_465802.1\|2364753_2365599_-	L-alanoyl-D-glutamate peptidase	A0A059T7Y8	Listeria_phage	1.2e-140	96.1
NP_465803.1\|2365598_2365880_-\|holin	holin	A8ASL4	Listeria_phage	1.3e-40	93.5
NP_465804.1\|2365892_2366258_-	protein gp23	Q9T1A0	Listeria_phage	7.4e-12	100.0
NP_465805.1\|2366287_2366446_-	protein gp22	Q9T1A1	Listeria_phage	3.0e-18	98.1
NP_465806.1\|2366450_2366768_-	protein gp21	Q9T1A2	Listeria_phage	1.3e-49	92.4
NP_465807.1\|2366779_2367853_-	protein gp20	Q9T1A3	Listeria_phage	1.4e-188	95.0
NP_465808.1\|2367852_2368881_-	protein gp19	Q9T1A4	Listeria_phage	4.6e-192	100.0
NP_465809.1\|2368881_2369907_-	protein gp18	Q9T1A5	Listeria_phage	1.9e-193	95.3
NP_465810.1\|2369915_2370734_-	protein gp17	Q9T1A6	Listeria_phage	2.2e-149	93.8
NP_465811.1\|2370735_2376099_-	tape-measure	A0A0B5CU25	Listeria_phage	0.0e+00	84.6
NP_465812.1\|2376109_2376715_-	protein gp15	Q9T1A8	Listeria_phage	1.3e-109	100.0
NP_465813.1\|2376720_2377143_-	protein gp14	Q9T1A9	Listeria_phage	4.1e-70	100.0
NP_465814.1\|2377197_2377530_-	protein gp13	Q9T1B0	Listeria_phage	1.8e-49	99.1
NP_465815.1\|2377459_2377894_-\|tail	major tail shaft protein	Q9T1B1	Listeria_phage	3.0e-76	97.9
NP_465816.1\|2377896_2378304_-	protein gp11	A8ASK1	Listeria_phage	2.0e-66	99.3
NP_465817.1\|2378303_2378642_-	protein gp10	A8ASK0	Listeria_phage	7.0e-57	98.2
NP_465818.1\|2378641_2379004_-	protein gp9	Q9T1B4	Listeria_phage	1.7e-61	95.0
NP_465819.1\|2379003_2379399_-	protein gp8	A0A059T5E3	Listeria_phage	4.8e-65	97.7
NP_465820.1\|2379417_2380419_-\|coat	phage coat protein	A0A059T6D4	Listeria_phage	4.1e-185	98.8
NP_465821.1\|2380418_2381009_-	scaffolding protein	Q9T1B8	Listeria_phage	7.7e-75	89.2
NP_465822.1\|2381087_2382227_-	protein gp4	Q9T1B9	Listeria_phage	1.5e-199	93.9
NP_465823.1\|2382227_2383988_-\|portal	portal protein	Q9T1C0	Listeria_phage	6.3e-266	92.9
NP_465824.1\|2384000_2385332_-\|terminase	terminase large subunit from bacteriophage A118	Q9T1C1	Listeria_phage	1.1e-259	98.0
NP_465825.1\|2385300_2386095_-\|terminase	terminase	A8ASJ1	Listeria_phage	1.6e-11	70.4
NP_465826.1\|2386140_2386680_-	hypothetical protein	NA	NA	NA	NA
NP_465827.1\|2387045_2387480_-	hypothetical protein	A8ASQ1	Listeria_phage	4.3e-75	99.3
NP_465828.1\|2387498_2387663_-	hypothetical protein	A8ASQ0	Listeria_phage	2.5e-20	92.6
NP_465829.1\|2387791_2388175_-	hypothetical protein	A0A0B5CYS3	Listeria_phage	2.0e-63	97.6
NP_465830.1\|2388178_2388583_-	hypothetical protein	A8ASP7	Listeria_phage	1.2e-58	85.8
NP_465831.1\|2388527_2388710_-	hypothetical protein	A8ASP6	Listeria_phage	1.4e-16	77.8
NP_465832.1\|2388728_2389211_-	single-stranded DNA-binding protein	A8ATZ7	Listeria_phage	2.0e-81	98.8
NP_465833.1\|2389207_2389387_-	hypothetical protein	A0A076G7F4	Listeria_phage	8.1e-20	87.3
NP_465834.1\|2389490_2389658_-	hypothetical protein	NA	NA	NA	NA
NP_465835.1\|2389654_2390116_-	hypothetical protein	D9J0I6	Brochothrix_phage	6.7e-18	35.9
NP_465836.1\|2390112_2390583_-	hypothetical protein	A0A060AFJ6	Listeria_phage	2.9e-40	89.7
NP_465837.1\|2390579_2391023_-	hypothetical protein	A8ASP1	Listeria_phage	2.1e-45	87.1
NP_465838.1\|2391019_2391217_-	hypothetical protein	A0A0B5CU49	Listeria_phage	2.0e-27	95.4
NP_465839.1\|2391219_2391816_-	hypothetical protein	Q8W5X2	Listeria_phage	5.8e-54	52.5
NP_465840.1\|2391812_2392625_-	site-specific DNA-methyltransferase	Q8W5X3	Listeria_phage	4.8e-152	95.6
NP_465841.1\|2392621_2393596_-	hypothetical protein	A8ASN4	Listeria_phage	1.3e-164	92.0
NP_465842.1\|2393612_2394311_-	hypothetical protein	A0A059T676	Listeria_phage	1.1e-109	100.0
NP_465843.1\|2394316_2394793_-	hypothetical protein	A0A059T5F1	Listeria_phage	3.4e-57	80.4
NP_465844.1\|2394789_2394984_-	hypothetical protein	A0A059T6E8	Listeria_phage	1.6e-29	100.0
NP_465845.1\|2395289_2395478_-	hypothetical protein	Q9T175	Listeria_phage	2.0e-21	79.0
NP_465846.1\|2395585_2395801_-	gp44	Q9T176	Listeria_phage	1.1e-28	94.4
NP_465847.1\|2395797_2396331_-	hypothetical protein	A8ATY1	Listeria_phage	7.4e-77	86.7
NP_465848.1\|2396453_2397230_-	anti-repressor	A0A0B5D0I2	Listeria_phage	1.6e-141	98.8
NP_465849.1\|2397211_2397487_-	hypothetical protein	NA	NA	NA	NA
YP_008475639.1\|2397293_2397491_+	hypothetical protein	Q9T179	Listeria_phage	4.0e-20	96.0
NP_465850.1\|2397492_2397774_-	hypothetical protein	A8ATX8	Listeria_phage	1.8e-37	95.7
NP_465851.1\|2397799_2398084_-	hypothetical protein	A0A0B5D168	Listeria_phage	4.5e-41	85.1
NP_465852.1\|2398286_2398529_-	XRE family transcriptional regulator	NA	NA	NA	NA
NP_465853.1\|2398684_2399161_+	hypothetical protein	A8ASM2	Listeria_phage	9.0e-42	62.0
YP_008475640.1\|2399319_2399487_+	hypothetical protein	NA	NA	NA	NA
NP_465854.1\|2399541_2400243_+	hypothetical protein	A0A0B5D125	Listeria_phage	4.7e-87	86.3
NP_465855.1\|2400263_2400944_+	hypothetical protein	NA	NA	NA	NA
NP_465856.1\|2401007_2402366_+\|integrase	integrase	Q8LTD8	Listeria_phage	2.3e-255	98.9
YP_008475641.1\|2402356_2402833_+	hypothetical protein	NA	NA	NA	NA
NP_465857.1\|2402887_2403235_-	transcriptional regulator	A0A0A7RTK4	Clostridium_phage	9.9e-06	40.7
2411019:2411034	attR	NA	NA	NA	NA

DBSCAN-SWA_5

2546529 : 2554373

Streptococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
NP_465995.1\|2546529_2547501_-	hypothetical protein	Q7AWZ3	Streptococcus_phage	5.2e-52	39.4
NP_465996.1\|2547508_2548477_-	hypothetical protein	A1IMD5	Streptococcus_phage	6.7e-68	43.3
NP_465997.1\|2548478_2549354_-	hypothetical protein	A0A0R8VB27	Thermobifida_phage	3.2e-08	29.7
NP_465998.1\|2549461_2551192_-	phosphoglucomutase	A0A1X9I671	Streptococcus_phage	1.3e-175	54.0
NP_465999.1\|2551233_2552295_-	aldose 1-epimerase	NA	NA	NA	NA
NP_466000.1\|2552311_2553295_-	UDP-glucose 4-epimerase	A0A2K9L1R4	Tupanvirus	2.6e-51	37.2
NP_466001.1\|2553413_2554373_-	thioredoxin reductase	G3MA85	Bacillus_virus	2.0e-88	53.7

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_003210

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection