CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_005027	Rhodopirellula baltica SH 1, complete genome	2 crisprs	WYL,csa3,RT,Cas9_archaeal,cas3,DinG,DEDDh	0	0	3	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_005027_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_005027_1

450475-450584

Orphan

Consensus_repeat	Method
CAAGTTCCCGTGACGACGGAAGTCGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_005027_1

>merge|NC_005027|1|450475-450584|CRISPRCasFinder
CAAGTTCCCGTGACGACGGAAGTCGAACAGACTTACACCGTCATGGTTCCAAAGAAGAGCACCGTCGAAGAAACCTACACGGTTCAAGTTCCCGTCACGACGGAAGTCGA

>NC_005027|1|1|450475-450584|CRISPRCasFinder
CAAGTTCCCGTGACGACGGAAGTCGA	ACAGACTTACACCGTCATGGTTCCAAAGAAGAGCACCGTCGAAGAAACCTACACGGTT
CAAGTTCCCGTCACGACGGAAGTCGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_005027.1\|WP_007338375.1\|458118_458598_+\|hypothetical-protein	unknown	unknown	unknown
NC_005027.1\|WP_164921354.1\|464119_465733_+\|VCBS-repeat-containing-protein	unknown	unknown	gnl\|CDD\|379232
NC_005027.1\|WP_011118098.1\|445095_449727_+\|tandem-95-repeat-protein	unknown	unknown	gnl\|CDD\|380078
NC_005027.1\|WP_011118101.1\|454220_456329_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|374041
NC_005027.1\|WP_011118090.1\|434674_435073_+\|hypothetical-protein	unknown	unknown	unknown
NC_005027.1\|WP_007324689.1\|458730_460359_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|378935
NC_005027.1\|WP_007331285.1\|460892_461063_+\|hypothetical-protein	unknown	unknown	unknown
NC_005027.1\|WP_011118097.1\|442146_444654_-\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173803
NC_005027.1\|WP_011118084.1\|431573_432953_+\|group-II-intron-reverse-transcriptase/maturase	RT	pfam00078_RT_CAS-I:CAS-III	gnl\|CDD\|275209
NC_005027.1\|WP_164921350.1\|433663_433918_+\|hypothetical-protein	unknown	unknown	unknown
NC_005027.1\|WP_164921353.1\|461220_462450_+\|DUF1559-domain-containing-protein	unknown	unknown	gnl\|CDD\|284919
NC_005027.1\|WP_164922663.1\|438955_440815_-\|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|224482
NC_005027.1\|WP_007324693.1\|453153_454224_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224117
NC_005027.1\|WP_164921351.1\|434156_434627_+\|hypothetical-protein	unknown	unknown	unknown
NC_005027.1\|WP_011118092.1\|435505_438748_-\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223911
NC_005027.1\|WP_011118102.1\|456325_457825_-\|MotA/TolQ/ExbB-proton-channel-family-protein	unknown	unknown	gnl\|CDD\|376576
NC_005027.1\|WP_164922662.1\|435128_435359_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377558
NC_005027.1\|WP_007331288.1\|462533_463790_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|274350
NC_005027.1\|WP_011118095.1\|440831_441593_-\|CerR-family-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|378136
NC_005027.1\|WP_007324694.1\|452223_453138_+\|lactate/malate-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|133418

Protein	Function_ID	Function_description	E-value
NC_005027.1\|WP_011118098.1\|445095_449727_+\|tandem-95-repeat-protein	gnl\|CDD\|380078	pfam17963, Big_9, Bacterial Ig domain. This entry represents a wide variety of bacterial Ig domains.	4.51221e-17
NC_005027.1\|WP_011118101.1\|454220_456329_-\|hypothetical-protein	gnl\|CDD\|374041	pfam15710, DUF4671, Domain of unknown function (DUF4671). This family of proteins is found in eukaryotes. Proteins in this family are typically between 385 and 652 amino acids in length.	0.000803654
NC_005027.1\|WP_007324689.1\|458730_460359_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	2.0167e-08
NC_005027.1\|WP_164921354.1\|464119_465733_+\|VCBS-repeat-containing-protein	gnl\|CDD\|379232	pfam13517, VCBS, Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella. This domain of about 100 residues is found in multiple (up to 35) copies in long proteins from several species of Vibrio, Colwellia, Bradyrhizobium, and Shewanella (hence the name VCBS) and in smaller copy numbers in proteins from several other bacteria. The large protein size and repeat copy numbers, species distribution, and suggested activities of several member proteins suggests a role for this domain in adhesion (TIGR).	1.09837e-06
NC_005027.1\|WP_011118097.1\|442146_444654_-\|S8-family-serine-peptidase	gnl\|CDD\|173803	cd07477, Peptidases_S8_Subtilisin_subset, Peptidase S8 family domain in Subtilisin proteins. This group is composed of many different subtilisins: Pro-TK-subtilisin, subtilisin Carlsberg, serine protease Pb92 subtilisin, and BPN subtilisins just to name a few. Pro-TK-subtilisin is a serine protease from the hyperthermophilic archaeon Thermococcus kodakaraensis and consists of a signal peptide, a propeptide, and a mature domain. TK-subtilisin is matured from pro-TK-subtilisin upon autoprocessing and degradation of the propeptide. Unlike other subtilisins though, the folding of the unprocessed form of pro-TK-subtilisin is induced by Ca2+ binding which is almost completed prior to autoprocessing. Ca2+ is required for activity unlike the bacterial subtilisins. The propeptide is not required for folding of the mature domain unlike the bacterial subtilases because of the stability produced from Ca2+ binding. Subtilisin Carlsberg is extremely similar in structure to subtilisin BPN'/Novo thought it has a 30% difference in amino acid sequence. The substrate binding regions are also similar and 2 possible Ca2+ binding sites have been identified recently. Subtilisin Carlsberg possesses the highest commercial importance as a proteolytic additive for detergents. Serine protease Pb92, the serine protease from the alkalophilic Bacillus strain PB92, also contains two calcium ions and the overall folding of the polypeptide chain closely resembles that of the subtilisins. Members of the peptidases S8 and S35 clan include endopeptidases, exopeptidases and also a tripeptidyl-peptidase. The S8 family has an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The S53 family contains a catalytic triad Glu/Asp/Ser. The stability of these enzymes may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	2.80603e-49
NC_005027.1\|WP_011118084.1\|431573_432953_+\|group-II-intron-reverse-transcriptase/maturase	gnl\|CDD\|275209	TIGR04416, hypothetical_protein, group II intron reverse transcriptase/maturase. Members of this protein family are multifunctional proteins encoded in most examples of bacterial group II introns. These group II introns are mobile selfish genetic elements, often with multiple highly identical copies per genome. Member proteins have an N-terminal reverse transcriptase (RNA-directed DNA polymerase) domain (pfam00078) followed by an RNA-binding maturase domain (pfam08388). Some members of this family may have an additional C-terminal DNA endonuclease domain that this model does not cover. A region of the group II intron ribozyme structure should be detectable nearby on the genome by Rfam model RF00029. [Mobile and extrachromosomal element functions, Other].	1.94747e-158
NC_005027.1\|WP_164921353.1\|461220_462450_+\|DUF1559-domain-containing-protein	gnl\|CDD\|284919	pfam07596, SBP_bac_10, Protein of unknown function (DUF1559). A large family of paralogous proteins apparently unique to planctomycetes.	9.58546e-55
NC_005027.1\|WP_164922663.1\|438955_440815_-\|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|224482	COG1566, EmrA, Multidrug resistance efflux pump [Defense mechanisms].	1.77709e-23
NC_005027.1\|WP_007324693.1\|453153_454224_-\|hypothetical-protein	gnl\|CDD\|224117	COG1196, Smc, Chromosome segregation ATPases [Cell division and chromosome partitioning].	0.00599422
NC_005027.1\|WP_007331288.1\|462533_463790_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	6.81858e-09
NC_005027.1\|WP_011118092.1\|435505_438748_-\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|223911	COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms].	0
NC_005027.1\|WP_011118102.1\|456325_457825_-\|MotA/TolQ/ExbB-proton-channel-family-protein	gnl\|CDD\|376576	pfam01618, MotA_ExbB, MotA/TolQ/ExbB proton channel family. This family groups together integral membrane proteins that appear to be involved translocation of proteins across a membrane. These proteins are probably proton channels. MotA is an essential component of the flageller motor that uses a proton gradient to generate rotational motion in the flageller. ExbB is part of the TonB-dependent transduction complex. The TonB complex uses the proton gradient across the inner bacterial membrane to transport large molecules across the outer bacterial membrane.	1.73535e-09
NC_005027.1\|WP_164922662.1\|435128_435359_+\|hypothetical-protein	gnl\|CDD\|377558	pfam05818, TraT, Enterobacterial TraT complement resistance protein. The traT gene is one of the F factor transfer genes and encodes an outer membrane protein which is involved in interactions between an Escherichia coli and its surroundings.	0.00217667
NC_005027.1\|WP_011118095.1\|440831_441593_-\|CerR-family-C-terminal-domain-containing-protein	gnl\|CDD\|378136	pfam09209, DUF1956, Domain of unknown function (DUF1956). Members of this family are found in various prokaryotic transcriptional regulator proteins. Their exact function has not, as yet, been identified.	4.06978e-30
NC_005027.1\|WP_007324694.1\|452223_453138_+\|lactate/malate-dehydrogenase-family-protein	gnl\|CDD\|133418	cd00300, LDH_like, L-lactate dehydrogenase-like enzymes. Members of this subfamily are tetrameric NAD-dependent 2-hydroxycarboxylate dehydrogenases including LDHs, L-2-hydroxyisocaproate dehydrogenases (L-HicDH), and LDH-like malate dehydrogenases (MDH). Dehydrogenases catalyze the conversion of carbonyl compounds to alcohols or amino acids. LDHs catalyze the last step of glycolysis in which pyruvate is converted to L-lactate. Vertebrate LDHs are non-allosteric, but some bacterial LDHs are activated by an allosteric effector such as fructose-1,6-bisphosphate. L-HicDH catalyzes the conversion of a variety of 2-oxo carboxylic acids with medium-sized aliphatic or aromatic side chains. MDH is one of the key enzymes in the citric acid cycle, facilitating both the conversion of malate to oxaloacetate and replenishing levels of oxalacetate by reductive carboxylation of pyruvate. The LDH-like subfamily is part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.	2.6786e-135

>NC_005027.1|WP_011118098.1|445095_449727_+|tandem-95-repeat-protein
MTNAKTHHIDPAQPFELPRKQMKNLRQLLRSVSPSSSRKRSEDRSRSNRSNKRRLLSESLETRQLLAGDVPSVVDAAPEGEATYAVAHNYWRAYDVDNNKYVTALDALMVINHLNSHGEGEPLSGSDEFTGFVDVTGDNRVTALDALSVINALNRGEGEADMPLVEFVLAARNLDDTLVDNTTGATDVLPDDNVELTYNVDVNEVFKLEVGVKDLRGFSATGVFRAVTDIIIDQSDVLEPAVGEVQSIVFDNTVLNSPLEGNITFSFADNPSVTVTRSLNDFIGGSLGNGSNNLEEIIAQLSPLVGSADDVDVQSSINTSAGGPSGGGSYTMEINYSGPDLINVNMPQLQAVLEVNGTAQPVNLSQINVQNPDGSFNSTPILRALELNTRNAGNAGVYGQTRSFGSFELGEDLGSGLVDLFDEIGVLGPGDKSLAQELGSEYNPNLAYDAFSIPVRAVVPATGVSVSLDAPDEGDKVLIYGTEVGKESVPDNMIQLDASSRFILNVSGVSTGLTAANSTLSLTEDDSATTIDLATLNSGNPAGTTYAISSTTENLGDFALNGSVVTYTPDADAFGNGDQLVYTATDGTDTVTGTIAVTIAGVNDPPTLVDDTATVEQGETAQIDVLANDSAGPGENNADLVLQSPATAITTANGGSAIIANGQISYTAPAGFSGSDSFTYTVADGALTATANVVVTVTNSQTGINAANKTVTIDEDNGGGVTSEVLVADLSDDNLITINTGGTTITLDDAVITSGNGSVRIDGDQIFFTPAQDDFGTTTITYTASNDGTEGGSDTGVITVNITADNTDLTATADDFSVNEGATVTLDVLANDFDGPGESGVLTITAVGTPNFGTATITQNGTRISYTSTGSAADGDDSFTYTISDGQGGTSTAVVNIDIQDVLDAPIAGNGSETIDEDSGTFTFNLNDLVTLEGTDSVTFSKVSGTDAIGTSTVAANGTLTFNPVLNANGTATIVYRATSTQGSQLSDEGTLTISVTPVNDAPTATNRTVTVLEDNSIDIDLNGNVADIDSTGLVITVASNPGNGTATAIGNGQIRYTPVADFNGQDSFTYQVTDGNLTATATVTVNVTDVVSPPVANNGSLSATEDAGAVTLDLSTLINLDSGDSATVTITTAPTNGTANVSGTSGDLTNSTLSYTPSADYFGSDSLVYTVTNSQGATDTGTISISVAGVNDAPVAGNDTATTVRNRAVTIDVLSNDSLGPANENQTATVTVPTQPANGTVTVNANNELVFTPATDFVGTATITYQLSDGDLTDTATVEVTVNDFSPSVISGQLFVDGIMNIRDVIDNGADPVRNGVRDPGETALGGVAVRLVSAASQNELGVDIDQVVLTNLDGEYTFEDVAPGSYQVIYNLPNNAVAAGEAADGIIPIEIGSDGGASPVGSFAFATLGDAGQGNSSILSTNTNGGNGLPSGVDPGEGGFINLVDGAQTMFLAGSGFDGVAYAELAMNRNNDAALLTIIEEDGDVRTAQVDGDHLRVNRSGTSVQLLGGVDDFDFDASLEDLIESEYPAFRDAIDMILGNS
>NC_005027.1|WP_011118097.1|442146_444654_-|S8-family-serine-peptidase
MSNSSHSPSNPNLTDSDALELPSPAIQPCEERLALSASLMGAWLAEWADPTQPLPACPADVLPIPATGTAAPASIPVAPAITPLPGATAADAFPVGPLFPGTSNGGLPSHSDTDTSVDGPSGLNFDSIVDGQSSGSLFDQAQSLRQEGGALAGDAETGALDGSGQTIAVIDSGIAYDHVALGGGYGPGYRVVGGYDFAENDDNPYDDAPAGYHGSHVAGIIGGDGYLDSGQAFQGLAPGADLVGLRVFDDAGNGNLQWIESALQWVIENHDTFENPITTVNMSLGTELTDANRFDAMAMLEDELQTLYENNIMVFAAAGNSYATMDHQNADALMYPASSQYVVGVGSVDPNNMLSDFSQREDGILTTGGQAVRSSVPEHVYGADGFANDYALLSGTSMASPQIAGASVLVRQAMTDAGMSPTVDSILARLNETADQHTDPVTGIQYKTLNLEAALAFSVSEPDPVPTPDPTPPTNPSPTPTPEPTPDPSPNPTPDPAPPANSLVSEYQGTSGSDEVVLDLRGLTSSVGGGINGETLLSDASGSYTLDTTEPIVINGGEGGDVLRIMGSAEAESLLLRPPSSGDGVSRLTFLGGVIEIRGFENISFVGGGGLDHATMYDSTGDDVLTASSQTARMSGVGFEFRVDNVPKLFAHATSGGEDSAHLNDSAGDDRLVIRPQFSSLRSDTQTQAVFGFERVYAYAEAGGHDSADLGDSAADDVMSISQTQATISSSGYRATAVGFDDVTAKASAGGEDTVRIYVTQPGGTWHTTDSLTQWNGSDGTSRIARGFEHSETFERFETSGQSIETKSTDSPQPLANPFDEEAHRDALRRMFEAL
>NC_005027.1|WP_011118095.1|440831_441593_-|CerR-family-C-terminal-domain-containing-protein
MQGKSRPSARFDPFMADPPETSVTDPTQRLLAAAGPVFAERGFDRATVREIANIADVNVAAVSYYFGDKMGLYRAVITAIREKRERAYPTPVVGKETPQQDLELLIRTLLSRMLAADETGWEAMLMMREMQHPTPAFEGMIRGYFRPLYDALCKTIESLLPPLDAKSSWQTDALVPQLALGVVGQCLHYRIGRPVMAHLISPEVIETHYGLDSLCRQITASTLAACGDQNVIDQHKLLKPSPLNEPQDVSCQQ
>NC_005027.1|WP_164922663.1|438955_440815_-|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit
MTEDEQSAEAKASPVSTTTAPSSAEPTRSPYEHGIEVDSPATETNTVQLIDSSNVFSWLMFNIGVPLLLLCAATALVVYLGAVQPSTRPAADTSLAGRLQALPAVDVVPTQSLADSGKTLHLNTDGTVVPFREVVLATEVAGRIIEKSPQCEAGQYVTAGTVLMRIDPTDYELTVRRLEQTQQSEYESINEIDQELINASRLLEIADADIELQSREVKRLDSLPEDFAARRDVDAARRAVLQAEQQKVTYQNQIDLLKKRRARLELAEQLAATQLKQARIDLERTEIRAPIDGVIASEQAELNTFVARGNPVVTMEDTSKVEVATSLRTDQLYWVLNQKTSQSPIEELNAPANGAHRGYKLPPTEVKVQYQLSGRDDVTYVWDGQLVGYDGIGLDEQTRTVPVRVVVDHPQMFEIQRRGDEESTKRPTDESVISTGPTALVRGMFVRLQLQLQPAVPLVILPSEALKPGNRVWEFIPDDSVLDVAEEDAKAEDSDAVAKTDTDDSVAKEDDAQSTDNESDTEAEAEPEVAFVPDEWSPGRLVIRQDIRPIDLLSSIGGSSDFWICEVPDQSINGDSFVVVSPLGSIEADTFPVRAKKSNLTDPIEINLDSPSPEAITDL
>NC_005027.1|WP_011118092.1|435505_438748_-|efflux-RND-transporter-permease-subunit
MKRVLAWAIENAPGMNVVMLALVIIGAAAFVGMRREVFPEFELEVVMVSVPYPGATPQDAEEAICQKIEEAIRSIDGIKKVTSIAMEGRGYVLAEMQSDIQDVQKVMSEIDREVNRIPSFPDLAEDPEIEQITFRDTAIRLGIIGPDDRTRRGELKLREVAESVRDDLLMLPSVTVAELMGTRNYQIDVEIPEATLRSYGMTLDQVASEIRQHNVELPGGQLKSSGQEILLRAKNKGRVGPEIERIPLITRQDGVVLTVGDLGNVRDEFEDVTATAEINGEPAMVINVQRTKSEDLLNLVDDVRGYVARTEAPPGYRFVLWGDTSVDVRDRMALLLRNGVQGLGLVFLVLALFLEVRLAFWVALGIPISIMGAGAALAWGDQTLNMLSLFSFLIALGIVVDDAIVIGENVYAHRQMGKSLHDAAVDGATEVLPSVAASITTTVIAFAPMFFVSGVMGKFMAVIPFAVIAMLLVSLWESTFVLPCHLAHSHSGFFRVATIVTYPLRPFMLLLFWLNSKASIAMEWFAEKVYVPSLHFCLLNPVLPIAVAIALFVGTAGMIRGGVVTTVLFPKSDNNYLQASVVFPNGTPASATEAATKRMERALQKVSREIALERAAETRQPVESLYPPPEADYLGPVRFAYREVGSITNTAGPMGGQGSSGSNAGQIFAELHGTEIREVHSDQLIARWRREVGEIAGVERIIYGSIGTGPAGTPIEFKLLASSEHVDELLAATEVMKQKVGTFAGVFDISDDNTPGKWEFQFRVKDKALATGVTPTDLGQTVRNTYFGAEVMRLQRGRHEVKLMVRYPPEERTSLVNFREIRVGGADGTQRPINELAEINLERGFSEINRVDQQRSITISADLDETTANADLIIASLQKQMDGFIAQFPNVSIRWEGQQEQSRESVGSLMVGFAVAILCMFVLLVLQFRSYMQPLLILAIIPFGMIGAVWGHAFLDLPLTLFSMFGLVALAGVVVNDSIVLIDFINSRVRAGDEPIQALLESGRRRFRPIMLTSMTTIAGLIPLLTEKSFQAQLLIPMASSLAFGLMLATALVLLLIPVLYMLYLLTLQSLNIPFVEVEE
>NC_005027.1|WP_164922662.1|435128_435359_+|hypothetical-protein
MEERANDAIVNLIAGGLLGAVGGAGLGFSVSLAFTGWAVVAFFAGGVLGGVLGMTIGYVRGDSFTEWLKENLWRFW
>NC_005027.1|WP_011118090.1|434674_435073_+|hypothetical-protein
MRRKHGNRLQWFGIGVFMLGSLLLLMNAWQGQQSRNARDSVQDRIDVLEAFVARAESDTMTAQEIRQLGNRLDSVSSDLMALKRESDSPWSALNVSFMSSVACSLIGSVLTIVGSSRLRRGGIPAVEGAQDD
>NC_005027.1|WP_164921351.1|434156_434627_+|hypothetical-protein
MVVKRFRISTLLIFTALCAGAFVVLRPFDPQVRIYDPVDLDRYHGYYHGAKIYEVSVVNAGGHAIWLPDNSEPFASSAIGHFVGGVRTNRVFVWAEDRGFKQVQPGEGLVYQICMSESDADFEVVIEVQDWRGSSQRIDDRVYVLKPSEARESSAS
>NC_005027.1|WP_164921350.1|433663_433918_+|hypothetical-protein
MANLKDPRWIWFKGGLFVVTGVLASLVLIANSPSVQTIVLLAVAIWSFCRAYYFAFYVIERCVDPKSVDARVRGCCRPSVCCGQ
>NC_005027.1|WP_011118084.1|431573_432953_+|group-II-intron-reverse-transcriptase/maturase
MPAKRKSKDYIPVTVPFSAESPSAKASRAGEPEKKSAIEISSWANRVVWTDRMLNALSVGVRGGKWHALIDKVYRELNLFVSARKVVGKKGAAGVDRQSTEDFSEKEIAEIKQLYEQLRTGTYRPQAVRRVQIPKPGSKQTRPLGIPTVRDRVVQTALVNVIEPIFDNEFHERSFGFRHGRSCHDALRVVEELLETDHVFVVDADLQGYFDTIPKDRLLALVSEKISDRRVLDLVKRFLDQSILEELREWTPESGVPQGAVLSPLLSNLYLNELDHRMADLGYEMVRYADDFVILCRSQEQAELALEEVKRFVCEAGLTLHPEKTHIVDSRVNSFDFLGYSFRGKLRFPRAKSHQKMVDTIRRLTPRKSGQSLEATIVQINRVTVGWFSYFRHCTWNIFDKYDGMVRKRLRRQLLKRHRRNPQRLCRTHRWPNAYFSERGYRSLRLAHSAYVQSLDGTH
>NC_005027.1|WP_007324694.1|452223_453138_+|lactate/malate-dehydrogenase-family-protein
MKITLVGTGRVGSAIAFALTINPLASELLLLNRSREKAEGDALDLTHAAALVDSNIKISSGEIADSKDSDVIIFTASVPFRYPNQTRLEMGIDNMPILRDWMPGLAKASPNAIVVMVSNPVDALAYETIRLTGFDPKRVIGTGTLVDSIRYRALLSTELKIHAQDIRAYILGEHGDTQFAASSIAMTGGERFYPSDTSRRMFEETKAMGYEVFRLKGHTSYGIAMATITILDSIAYDLRHTMPVSVLVDGYLGVEDVCLSLPAVIGREGVTRILHPTLSEDEEAAFRNSAEVVKQTLVEMEAGQ
>NC_005027.1|WP_007324693.1|453153_454224_-|hypothetical-protein
MSRRRRTTLELGHDAFLDIVANLVGILIILVVVLGTQTQRITRALTSPDEIAQKPGELVSPEGLPTPEPKLATDSQLSELAQTAMRAAAAQRESMRLENMVKRYDMELEQAKRERGALLDLLTLAEEAWEQKQKQLDQDKVRAAKLGSEMREVSAELATLAGTKERLESQESPVVAVEHLPTPMAKTVFGDEIHLRLKSDRLSVVPIEPLLKAIKEDFGRVIRGSRDGRSSSAVGPIRGYVAHYAMDKSTGRVSQGGKTSMGTRVQLAGMVIEPLEEPHGQPIDQVLTTSRLLDVELAGRDPSKTTITVWVYPESFAAFRMLKEHLYKRGFATAARPLPFDRPISGGPGGSRSQAQ
>NC_005027.1|WP_011118101.1|454220_456329_-|hypothetical-protein
MSRRRASLSPSLFPFLAVLVCTLGTLILLLALVAEKAQDTSVPQVAQHSEAVAPTPDSSDDEAPSTDNPADTLVDTDVPPAMTAASAIQLLEEEQFRVEQLVLHREKQTSKVECRRDELTLVQTATKKLRDRLKQLSDEVDAAIAPEDATKIDEQAIVMMREEMETLRREIAELEEVKSGDKPRVVIVPHRGPNGTARRPVYVECTENGVTIWPEDTRITHTQLLAGVQSGSPSRNPLDAALRVFRQHAVQNYGDGAPPYPLLIVRPDGIETFVTARAAMQDWDDQYGYELVPAEVDLAFPKPDRVLKPKMELAVHEAASRNIQQYIGDARGGAGGNGSGTRNMGGTMLGGAASLPSGNGFANADAFSAKPSSETLASGGTGNNGGPTDNPYTGQAGGATSQLGGATGSPMQPAEKPLPVLSARSLDRQARANGFMPSRDMGPPLPAGGLAEPIPGSSQSSFGAVETRSEALNDYLAQKDNPLLADSQSDTNQTPSANSNWMNDPSADGTDGESDADQTDPNFRGASSKVNGEQIAGMQQASGGQSASASVSQSSAAPPSSSQAPDSANQPPPSTNMQAPQQPTKTVRREGRDWALPRSMAGINGTQVVRPIAMVCHHDRYELVQNNVVVETFPFENNSIYNATMELATAVRDRVDGWGATLPGGRWQPRLDVLVAPHADQRFHELQTLMNGSGVEITRRIR
>NC_005027.1|WP_011118102.1|456325_457825_-|MotA/TolQ/ExbB-proton-channel-family-protein
MKPHDFNANDTVSPADHWGEPVEPLTKLQATTPASTGEPSASTSANQPTDLVDSPSMLSKIVASVGPIGLGLVLSAVFYGVVFGVNWGPLNRYFLGHPVAVAAAILFCVAIAILAVRAVQVARDRHQLELLRDEDLMAHATGATSDSPAQRWLQQNDAGAIARTWRKSLRSLPSSTRNSLLVRRLNEVLGRQSHRTGTGDLPQDLREMSERDADAAHDSFGLIRIIVWAIPMLGFLGTVIGITQTLGGLDFTDGTAAVDRLKSGLYVAFDTTALGLVLSVLAIFLQFPVERSQQSLLASVDQRVRDLVSEALPSDDAGDSQTALVTQLCDGIRVAVQESLATQAKLWRETIEEAQASWRTQHNEGSEQFRKLMQASLQPALTSHADRIEATVSRLDMIGSGVSQTLQDQTKAWNDAMHTTAVEVQTHRRTLMTHTEAMTELAAQQSMRNQTEAPVVELDPVMGEAMRTLARAVDTLSQRLPAAKTTGGRDDSTSKRRAA
>NC_005027.1|WP_007338375.1|458118_458598_+|hypothetical-protein
MPRRFACFRLFSGEITMRTNLVASMVCVGFGVLIGLCLSLDSADHVFAQDSPAIRQPESLAGVPHSLDGTPTLIQARPGRDVGASGEIIGFSHVDESGTQVISLVNTGKLWMAVYHVGPDGEIRLVSSRAIDADFSLELNATAPLPDDIRRMQGKTKPR
>NC_005027.1|WP_007324689.1|458730_460359_+|helix-turn-helix-domain-containing-protein
MASYLSLEDAAKQLGIPADKLIDLRSQGQVRGFRDGSSWKFPEAEIERLKDELPNMSGLGSGILAADGGGSKIGSVIGGDNPASDDSGLDLDIDSLTGGSDVNLIASDSGDGSDVTIVPGAKADSDAPLKIDLDDLNLSGSAISHDSGDLELESPTPGPQSNSDSDEFNLGSSLGLDSDSDDLTLEPVKGTAPVEGAKSQSDLSGLGGEDSDGQLDLGDISSDEQASSLELMGDLDLDSSPSAIESKSHAGSDVLSELDLLAGDAAGSGLLSGSGDLLGSSLMSAESGGSSGVDDALADDDDLIIADDDDDLVVSGAGSDISIAGDSGINLMSPSDSGLSLESEPLDLAGSSISALDLGAELNEGSGTGSGHDGSGLVPASEMGSGIDFKGDDEFQLSASGIQIDGNEESASQVIEVVDSESVDIEEVDFDGADQVDAFDEAGDSGFAMDDDVAEVDALDDPMDGDGLIDENAAVASAGAGVRGGYEVPFTLLQTIGLLLILSVMSLGGMLMTDLVRNMWSYAEPSAPVSALTDMLISVAGW
>NC_005027.1|WP_007331285.1|460892_461063_+|hypothetical-protein
MKHLFSLTLLFACLTLAFSGCDKAEVVEPTAAEEPVELTPEEQAEYDKEMAQQMGN
>NC_005027.1|WP_164921353.1|461220_462450_+|DUF1559-domain-containing-protein
MSNRSKSRTGFTLVELLVVIAIIGVLVGLLLPAVQAAREAARRMSCSNNFKQLGLAVHNYHSAYNQLPTNYGGTTPVAPLNAGPGGVTNWWENSNFGNHELLSMLIGLTPFVEAQGTWEQISNPFPADTNNDGTIDITFPAMGPTPTPGGADRNYYSPWMTDLPFLRCPSDPGRGAPTMGRTNYAPCVGDNMNRWNGGKNGDLTVNNWAMGVQSRNRGFFIPRDVSKFRDILDGLSNTIAMAEIATDLNDGDKRTSLAVTTGGTYLSNPNHCEQNFLDPERPQFWIDPDSPGSGQSPGDEPRGLGAATSRGARWANARPIFATVNTILAPNKGVCADSWPENGAIAPPSSRHQGGVHILMGDGAVKFITDSIEAGNASAPMPNPGQKSPYGVWGALGTRASREVIDTEF
>NC_005027.1|WP_007331288.1|462533_463790_-|tetratricopeptide-repeat-protein
MVVLLSFPLTVTTGCGKQDPPEARQTPERPLGELRLAMRKQKWAEAWQYSDAVLKAHPDDADAIASVAMVAQHLEKPNEVADLLTKACSVESFSNDGRVRQAMIALVGAGRLYDAIDLLEETIEAVPSRHATRRWLYDLYINSGNRAEAIPHGRTLVRQRQFDTKLLLSLGIPPSAKDDLGSTLEMVRRNPDDKRPLLRQANKLLNSGEVDEATKLLQQITGQHPEFQPAQLLYAMALAESGDIDAYEQWLSKQDTSSLDTKAEYWIAKATIAAAKKDPQNALRFYWNASQRNPDLTKPWSSILKLANDLKIDSPDQISSITDRLESLQQIRSSMERFDQMGSISRRLATDIAVELEKLGRLWEAEAWASIAMTLPRDDTVDVESVRAKIVGQLTGQTPWQVSEGRPDLQSELPIEFQ
>NC_005027.1|WP_164921354.1|464119_465733_+|VCBS-repeat-containing-protein
MQNLRTHAVFVTLVMMFASIGGCRERANEPVASTPSPPTDVQTASTQRSKEWHERVDREVKAFCADCHVLPLATSSERDHWPGEVDQGLNLYEVSGRTDLKVPARDDVIAFFEMQAPEKFDWSPWTKSFPQCRIDFNTQAVGLASDESTRPRPPGITNVRWLDIGMNDGPALVYCDIGSGAVVAHWPNRDGGTSKHLATLFQPVHAEACDLDGDGYKDIVVADIGEFDANDSDLGRIIWLRRHPSQEEFEQVVLMEGLGRVADARPADFDNDGDLDLIVAEFGWRQSGRIVLLENQISEATVEVADGKQLAKSFVAHEVDNRHGSIHVPPVDLNEDGLMDFVAAISQGYETVEAFLNDGEGGFDREVIFAAPDPAFGLSGIQLVDLDQDDDLDVLMTNGDSFDRGVKPYHSICWLENEGAFPYTVHELCKMPGVLSAKAGDFDGDGDLDVVAGSLMAGPIQKQFEQFEMASILMLVQTEPGVFQPTSVQQRAHQHASIEVDDFDGDGKIDFAISNLLRTAKGNEPDVVIWWNQSSGP

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Crispr_ID: NC_005027_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_005027_2

5807840-5807978

Orphan

Consensus_repeat	Method
GTCGTGCTCGTGCTCAGGTCGTAGACCGGTGCTCGTGCTCGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_005027_2

>merge|NC_005027|2|5807840-5807978|CRISPRCasFinder
GTCGTGCTCGTGCTCAGGTCGTAGACCGGTGCTCGTGCTCGTCATCGAAACAAGCGAGTGGCGAACGACGTTTGATCCCGTCGCGATTGTGCTTCCCGTCGTGCTCGTGCTCAGGTCGTAGACCGGTGCTCGTACTCGT

>NC_005027|2|2|5807840-5807978|CRISPRCasFinder
GTCGTGCTCGTGCTCAGGTCGTAGACCGGTGCTCGTGCTCGT	CATCGAAACAAGCGAGTGGCGAACGACGTTTGATCCCGTCGCGATTGTGCTTCCC
GTCGTGCTCGTGCTCAGGTCGTAGACCGGTGCTCGTACTCGT

Protein	Signature genes	Signature genes Name	Protein_function
NC_005027.1\|WP_007324221.1\|5813101_5813809_+\|MotA/TolQ/ExbB-proton-channel-family-protein	unknown	unknown	gnl\|CDD\|223881
NC_005027.1\|WP_007324223.1\|5814416_5815151_+\|biopolymer-transporter-ExbD	unknown	unknown	gnl\|CDD\|376792
NC_005027.1\|WP_011122879.1\|5804627_5806019_-\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340831
NC_005027.1\|WP_011122893.1\|5821021_5822908_+\|hypothetical-protein	unknown	unknown	unknown
NC_005027.1\|WP_164922996.1\|5798530_5799862_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225153
NC_005027.1\|WP_011122876.1\|5800167_5802507_-\|membrane-protein	unknown	unknown	unknown
NC_005027.1\|WP_011122894.1\|5822908_5825029_-\|NAD-dependent-DNA-ligase-LigA	unknown	unknown	gnl\|CDD\|236137
NC_005027.1\|WP_007324222.1\|5813808_5814297_+\|biopolymer-transporter-ExbD	unknown	unknown	gnl\|CDD\|376792
NC_005027.1\|WP_007324135.1\|5789965_5790514_+\|hypothetical-protein	unknown	unknown	unknown
NC_005027.1\|WP_011122868.1\|5788592_5789888_-\|DNA-repair-exonuclease	unknown	unknown	gnl\|CDD\|277319
NC_005027.1\|WP_011122892.1\|5818658_5821040_+\|peptide-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173853
NC_005027.1\|WP_011122885.1\|5809697_5811395_+\|alanine:cation-symporter-family-protein	unknown	unknown	gnl\|CDD\|376500
NC_005027.1\|WP_164922995.1\|5790484_5796322_-\|DUF11-domain-containing-protein	unknown	unknown	gnl\|CDD\|307488
NC_005027.1\|WP_011122891.1\|5815263_5818653_+\|PQQ-binding-like-beta-propeller-repeat-protein	unknown	unknown	gnl\|CDD\|199834
NC_005027.1\|WP_011122884.1\|5808254_5809544_-\|alkaline-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366747
NC_005027.1\|WP_081585041.1\|5807428_5807791_+\|four-helix-bundle-protein	unknown	unknown	gnl\|CDD\|377534
NC_005027.1\|WP_011122872.1\|5796490_5798362_-\|sulfatase-like-hydrolase/transferase	unknown	unknown	gnl\|CDD\|293767
NC_005027.1\|WP_011122878.1\|5802929_5804603_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238362
NC_005027.1\|WP_007334998.1\|5806078_5807173_+\|tRNA-dihydrouridine-synthase-DusB	unknown	unknown	gnl\|CDD\|223120
NC_005027.1\|WP_011122886.1\|5811855_5812854_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_005027.1\|WP_007324221.1\|5813101_5813809_+\|MotA/TolQ/ExbB-proton-channel-family-protein	gnl\|CDD\|223881	COG0811, TolQ, Biopolymer transport proteins [Intracellular trafficking and secretion].	6.80884e-20
NC_005027.1\|WP_164922996.1\|5798530_5799862_-\|hypothetical-protein	gnl\|CDD\|225153	COG2244, RfbX, Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only].	3.52412e-05
NC_005027.1\|WP_011122891.1\|5815263_5818653_+\|PQQ-binding-like-beta-propeller-repeat-protein	gnl\|CDD\|199834	cd10276, BamB_YfgL, Beta-barrel assembly machinery (Bam) complex component B and related proteins. BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.	3.80354e-09
NC_005027.1\|WP_011122894.1\|5822908_5825029_-\|NAD-dependent-DNA-ligase-LigA	gnl\|CDD\|236137	PRK07956, ligA, NAD-dependent DNA ligase LigA; Validated.	0
NC_005027.1\|WP_007324222.1\|5813808_5814297_+\|biopolymer-transporter-ExbD	gnl\|CDD\|376792	pfam02472, ExbD, Biopolymer transport protein ExbD/TolR. This group of proteins are membrane bound transport proteins essential for ferric ion uptake in bacteria. The Pfam family consists of ExbD, and TolR which are involved in TonB-dependent transport of various receptor bound substrates including colicins.	2.31244e-11
NC_005027.1\|WP_011122879.1\|5804627_5806019_-\|glycosyltransferase-family-4-protein	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	1.07428e-22
NC_005027.1\|WP_011122868.1\|5788592_5789888_-\|DNA-repair-exonuclease	gnl\|CDD\|277319	cd00840, MPP_Mre11_N, Mre11 nuclease, N-terminal metallophosphatase domain. Mre11 (also known as SbcD in Escherichia coli) is a subunit of the MRX protein complex. This complex includes: Mre11, Rad50, and Xrs2/Nbs1, and plays a vital role in several nuclear processes including DNA double-strand break repair, telomere length maintenance, cell cycle checkpoint control, and meiotic recombination, in eukaryotes. During double-strand break repair, the MRX complex is required to hold the two ends of a broken chromosome together. In vitro studies show that Mre11 has 3'-5' exonuclease activity on dsDNA templates and endonuclease activity on dsDNA and ssDNA templates. In addition to the N-terminal phosphatase domain, the eukaryotic MRE11 members of this family have a C-terminal DNA binding domain (not included in this alignment model). MRE11-like proteins are found in prokaryotes and archaea was well as in eukaryotes. Mre11 belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	1.14708e-52
NC_005027.1\|WP_011122892.1\|5818658_5821040_+\|peptide-ABC-transporter-substrate-binding-protein	gnl\|CDD\|173853	cd00995, PBP2_NikA_DppA_OppA_like, The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold. This family represents the periplasmic substrate-binding domain of nickel/dipeptide/oligopeptide transport systems, which function in the import of nickel and peptides, and other closely related proteins. The oligopeptide-binding protein OppA is a periplasmic component of an ATP-binding cassette (ABC) transport system OppABCDEF consisting of five subunits: two homologous integral membrane proteins OppB and OppF that form the translocation pore; two homologous nucleotide-binding domains OppD and OppF that drive the transport process through binding and hydrolysis of ATP; and the substrate-binding protein or receptor OppA that determines the substrate specificity of the transport system. The dipeptide (DppA) and oligopeptide (OppA) binding proteins differ in several ways. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Similar to the ABC-type dipeptide and oligopeptide import systems, nickel transporter is comprised of five subunits NikABCDE: the two pore-forming integral inner membrane proteins NikB and NikC; the two inner membrane-associated proteins with ATPase activity NikD and NikE; and the periplasmic nickel binding NikA, which is the initial nickel receptor that controls the chemotactic response away from nickel. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand binding domains of ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	3.57305e-16
NC_005027.1\|WP_011122885.1\|5809697_5811395_+\|alanine:cation-symporter-family-protein	gnl\|CDD\|376500	pfam01235, Na_Ala_symp, Sodium:alanine symporter family.	6.53194e-157
NC_005027.1\|WP_164922995.1\|5790484_5796322_-\|DUF11-domain-containing-protein	gnl\|CDD\|307488	pfam01345, DUF11, Domain of unknown function DUF11. A domain of unknown function found in multiple copies in several archaebacterial proteins. Conserved N-terminal lysine and C-terminal asparagine with central asp/glu suggests that many of these domain may contain an isopeptide bond.	1.34688e-17
NC_005027.1\|WP_011122884.1\|5808254_5809544_-\|alkaline-phosphatase-family-protein	gnl\|CDD\|366747	pfam01663, Phosphodiest, Type I phosphodiesterase / nucleotide pyrophosphatase. This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1 / alkaline phosphodiesterase i / nucleotide pyrophosphatase (nppase). These enzymes catalyze the cleavage of phosphodiester and phosphosulfate bonds in NAD, deoxynucleotides and nucleotide sugars. Also in this family is ATX an autotaxin, tumor cell motility-stimulating protein which exhibits type I phosphodiesterases activity. The alignment encompasses the active site. Also present with in this family is 60-kDa Ca2+-ATPase form F. odoratum.	4.28183e-60
NC_005027.1\|WP_081585041.1\|5807428_5807791_+\|four-helix-bundle-protein	gnl\|CDD\|377534	pfam05635, 23S_rRNA_IVP, 23S rRNA-intervening sequence protein. This family consists of bacterial proteins encoded within an intervening sequence present within some 23S rRNA genes. It folds into an anti-parallel four-helix bundle and forms homopentamers.	1.98114e-19
NC_005027.1\|WP_011122872.1\|5796490_5798362_-\|sulfatase-like-hydrolase/transferase	gnl\|CDD\|293767	cd16148, sulfatase_like, uncharacterized sulfatase subfamily. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.	1.86119e-34
NC_005027.1\|WP_011122878.1\|5802929_5804603_+\|hypothetical-protein	gnl\|CDD\|238362	cd00688, ISOPREN_C2_like, This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.	4.89669e-11
NC_005027.1\|WP_007334998.1\|5806078_5807173_+\|tRNA-dihydrouridine-synthase-DusB	gnl\|CDD\|223120	COG0042, COG0042, tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis].	2.35882e-104
NC_005027.1\|WP_007324223.1\|5814416_5815151_+\|biopolymer-transporter-ExbD	gnl\|CDD\|376792	pfam02472, ExbD, Biopolymer transport protein ExbD/TolR. This group of proteins are membrane bound transport proteins essential for ferric ion uptake in bacteria. The Pfam family consists of ExbD, and TolR which are involved in TonB-dependent transport of various receptor bound substrates including colicins.	1.61812e-20

>NC_005027.1|WP_081585041.1|5807428_5807791_+|four-helix-bundle-protein
MDVYRVAVDYVSSAFVVSDSLSGLHRHARDQWLRAAQSIPLNIAEGNGKRSLRDRARFLDIARGSALECSAIQDVLVATGGITSIRSEELKLPLVRVVAMLTRMAMKFGEVSEDGADYDI
>NC_005027.1|WP_007334998.1|5806078_5807173_+|tRNA-dihydrouridine-synthase-DusB
MIEKDATPVSAPTRTVPPLRIGDLVIDPPILQAPMAGFTNAAFRHIVRQFGGAGLLATEMVNARGFVWLDENEAEHPDRLWGVADEPRPLAVQIWDNDPETMAKVGRRLAEEYRVSVVDINFGCPVRQVTEKAHSGSYLLREPNRMHAIISRLVQVCAPTPVTAKIRLGCSRENINCNEIARVVEEAGAAALTVHGRTAADMFRGNADWERISEIKSHLRNIPLIGNGDLDSAEKVVAAFDQYDVDAVMIARACLGRPWLFAQAAAALRGEPIPPEPTLPEQRDVMLKHYQLVVDRFGDEKGTVLMRKYACCYAQGKHGARYFRTHVAKVSTPEEFHSVVEEYFPLHDPKAAKDTESVSSAAGS
>NC_005027.1|WP_011122879.1|5804627_5806019_-|glycosyltransferase-family-4-protein
MANRPFMNPKPFRVGLVAWHALPAIVPPTTFPHAVGDVAETATTERPSLKRYGETFGGLETAMWTLAQHLARQPDIQPVCFLEADRPRNGTMDWPTEVEGVKLEISVNRFRAIRHAVGECIDTESKRIKRFSPHLLWQIPFLAMTRPFRSRDPIDSHPDPRLTDRSIDAWISFGVNSSSSRVVATAAIEQTPSFVCIRSNAGLEDGLATDSEYRNECGEPSSARRYALMRSDQVVCQSQWQLNRLRQMFHREGLLARNPIVRKDWQPPFTNPAPKSFRNPFDVLWIGRYDDFHKRPLLMLEAANKLPHVSFKMIVNPFDPDIEKCVRREAPRNVELIDRVPFAQMPMVFAAAKLFVSTGSLEHEGFPNVLLQSAASHTPIVALSDHDNFLSRSGAGVDCNDFVELLAQRITEQLKSDAINWEKVDDYLDQHHSADLIASNFANWIRCSIANEPIVPATTGKNT
>NC_005027.1|WP_011122878.1|5802929_5804603_+|hypothetical-protein
MILKTLLWAFASLAAICIHTNTALAYTPFDTKVVNMVDRGLVYLENADPKDYHYGTSGFAGGLGERALVAYTHFKVKHDPNARVVQQGIAAVKTMVGVIRSGKRNVPGISFEVYSTAVAVMLLAEVDKEKYKSELKTLQGFLYELQYPNGAFSYIGHKTGDISQTQYGVLAIWTLDHAGIPLDYKRVAACAKWLIRVQDPSGGWPYQAEDPGAGRPNIRQKDVYPAMAYAGGSSILIAGDALRLWGDTSRSDMSAFPGAPKAIKLYVPDANSERRKGATVNSEKVIGAIKASDRYLANTEYKRAAKDYYYYQLYTQERYESFKEIALGLKPDESPSWYNQGVDELIGYQDPKSGGWGVEDHDHSGSVAGTCFAILFLIRSTQRSIAAASSGTLAGGQGLPKDTTKIRREGSQIKGEPVGASVLDLLSALEDDGNEALEGKSLPENMQLATDPKELRAQLDRLERLVRGSQSYQARRVAARLLGKSDDMRVVPALIYALSDPDLAVRRYARDGLRFISRRFEGFEMPDKPTEGELRKAERAWMDWYLTVNPKHIFVDQ
>NC_005027.1|WP_011122876.1|5800167_5802507_-|membrane-protein
MTESKGHGILCNKQRGDGPSSFPWLSLAIGFLAIASGILWLVPAELVEKAVTIGDGETARVLAAKLRELLLPFCAIGLIASAASWILGARAKSFYDLRLHSWLAATIDDQPRPQPYASLSVPEHLFWAGCAVIAVLTYDWRTLFWGFFESDDYSMVEVARDGDFPGSLLSTHNDHVLPLLRLEFSVLYEMFGTNPFAYNLGVIASFSLMLYAGCILARECSINRIGTLAFLFLCINWSLWGEFTAGSYILQKYMQITTCGLLSCWCWIRWEKTQRPGYFAGCVFAVLIACLMNPSGYWVPCAVLVFAALRLYSRRSTHPVRDTVRDGRSLTFAVIGVVALSMAVYRYAYSLPGNNEFLTLTDNPLTLGGFVQQLFVFVSTLIATVLVPLPHHFDKVGLLVPSLLLFLVAAGTIFAFGIHGLKRELKATAVALVLVLLGITAMVCLGRPIPGINYIVASKYLGPAYVWLCLIASFCIQGLWNATSTNSRSHWRLVRMVFSILAIALLTHGAIELGARAELPFLDRDVCRNSKLREQIRERNAIGRLRSEVIAVLEQNSTENLRLPNFSGDAIAHALPELAFPWGERPSLRMLMPMLESKPRTIRCLPLNGRYDEDASDATLRESISPSFFKQLQVNELLREIAFAPVDVEILDKTPSAKDGDFQHDQNSPPNSHLSLTTAKAGGSLQLRTLTGPWNPTSYPILRLKIAERQTVKLNLVVNGEFDIRVPHSVAINSEVGTEAHLNLAPLFEYSCSGDVRHIEFVGEELAKLSIESAELGNR
>NC_005027.1|WP_164922996.1|5798530_5799862_-|hypothetical-protein
MVNRLEVDRATFYAVATRYWQFVSGPVTLWLVVQFFTPEVQGFYVTFWSVIGLQMFFELAFPQTIVTMTSHLWSQLDLDNSNRLVGKPDAVSRLTHLMRISVVVQVILATLFAAIASFFGLWFFADDPSAQTITWRGPWLTLVGLSSIAFALIPFLAVLEGCDQVREIHKLNLVRGIAGSLVVWIAIPLGAALWIPAIATAVRLLCEIGWMLGKYPRFFATFAKRPTGERVAWRKEVWPFQSKLMLKGFFNYFNADVMLPVLFRYQDAVIAGQFGLTWNILQSMRMACSSWVRTRVPRFGVLIAERNYKELDRIYFRVGKIAASLLALLGCVFVLGVAGLDYFDFRYAHRFLPVLPTTLLIIGLWTALVFEFQWLYLHAHGKSPYLTLSLIACCISGLLIWWAGIYYGAIGVSLAFLFMQGIVYLPLSTVGWFHLRRQWHREE
>NC_005027.1|WP_011122872.1|5796490_5798362_-|sulfatase-like-hydrolase/transferase
MTRTRSFSSREPSTEWRWRSLLWAQFVGLAISMTLCWHSFDEVLQAEKPVGFLVATWRLFQAFLPLAVLFTVGNVLRCERWACAMMTGWWYWIMVDLIVHQWTGMHVASFEVLRLLYEKSLSLLPYVHLGMVIRFGIGFATLLLLTQVGRIATRRIARRCSDAGNSLSSLGASLAWLGAITLLAAPAWMFWATVQSEMRAEPSRHALSVIGWPASKRSDRPTLLAKESTSLKLTNASIRRRTQAFRLNVATNEPKQRPDILFIVVESLRPELIDSDVMPNVNAAAENGLWMQRHFSGGNASSLGLFSLFNGLDAIWFYRSDVRYAPAMNRLFHQSGYECGFFGAANDWAAFQMDAFVRKDVYDAFEVSSYDGLRSDRRAIQASEEFLADHADRRPRLAVLYLYATHAPFEINPLLQQDQPAASSNYSIPFGPANRELIWNRYRNSARTVDHLIAPLLKHPNRIVAIVGDHGESFLDDGTIGHGTRLSASQTQTPAIIVGRNVPTKKVREATSHADLLPTLLELCDIQTSSPMSFDGRDVSNPIFRPRVIAIADYLREQAILIPNEADLDPTFFGLQVGISLLKPHFQIIGTRSRQGDPRQFSHEELITHRQIARKYLDQTFPD
>NC_005027.1|WP_164922995.1|5790484_5796322_-|DUF11-domain-containing-protein
MNDSAPKCTRRGRRRLLLESLESRRLLAVASDLVTIRGQVTDSFIGGDFEDVALDLFRDDGDGVFEPDTGDVEVNMAMADPSGNYQFTGVTAGSYFVFQPAQTVNGRTLQQQISPLITVNSTQVAGQAFQTIDSFQTTQSVEDTVTDGTPVTSSQAAAEAIGGSRDLIVDKTQGGTGDIGTVAIGVNQAVSPNLLSFDANGFADGSRSVIWDGADDDAATVDDDGLGAIDLTSGGSATGLRFVIGSVTSGTAVIRLYSDDGIAGSRTLVSQATLTIPALPTQPTSVEYIPFSDFQAVSGSGADLTQIGAIELEVSGGPDYDAIADLLGTVGPTIIIQNIDNAGEADLELTKTLITTEPTLNQNVVFDVVVTNNGPDPATGIVVTDRIPAGIINTTGTTSTGTFTPGTGLWTIPNLAVGATATLRLTGQLDSLDPQTNVAEITAAEQLDADSPRDNNVLADDDQDAATVTATRVDLQLSKAVSDSQPNVGDEITFTLTLQNSSLDTATDATLSTATGILIEDRLPAGLSLVSNTPSAGTSFNTTTNRWSIPSLDVGGLATLQLVARVDQAGDFTNVAEVLAVAQTDRDSTPNNDLIDEDDQDEVLIQTPVADLSLTKTVSNESPTVGENVTFTITVDNEGPNNATGVRVQDSLPSGLTYISDVTSSGTYDPDTGLWTVGDVTAPNPGNPIPAMPTLQIIARVDSLGIKTNSATITASDQSDPDSTPGAGPSTEDDTDAATLTPNAIDLQLTKTVTPSRPEPGDSITYTITLSNAETSAAIPITTATNIQVTDLLPAGLILQDAQVTAGTHVDATGTWTVDSLAAGASETLTLTAILDPGRSDLFASITNTAEITQAAQFDPDSTPDNQDASEDDQASSVITPAQADLSLTKTVDNANADVGENVTFTITARHDSGDPSGQFIVLDTLPAGLEFVEATASIGDYDETTGRWTVPELDADSGTAAPSFATLEIVATTLSRGTLTNSAEIIQATLPDPDSTPGNGLIDEDDQADASVQAEQIDLELFKTVDNPTPRLGETIQYEIVVRNEGLDTATGVIVEENLPAGLTFIDATPTTGSFNSSSGRWTVGELAPSGSATLTINARVNNNVTADSPTITNRTEVIAAGQVDSDSTPDNNEPDEDDQASVTARVEFIDLSLEKTVDNPAPNVGDRVAFTITLTNDGETATTRDTATNIVVRDLLPAGMTYESNSLSDGSYDSDTGEWTIDSLADDATATLTLFAIVDQVGTQTNTAEVASVDQDDIDSTPDNNVAAEDDQASASITTPVIDLSLTQTASPQRPAINGEVTFTLTLRNDGPDDATGIIVRDSLPDGYTFTSSSPAGAFNSANGLWTVGNLASGEETTLELTGTIGDVETLENRAEVIAADQADRDSVPDSGLDDGEDDTAAAIVTLANADLSLTKTVDNASPNFGDEVTFTITVRNSGPDPATGIRVRDFLPAGMDLTDQTTSDGTYSPVTEIWMIDELESGQTATLTLTANVNSESLQTNVAEIMASDQRDPDSTPGNGDTDPAEDDRASVDVQAQLIDLALSKTVDGTRFDLDDPVEFELTVSNTGPTTATNVEIADSLPAGLIFVSSSTANGGYNPQSGTWSIPSIPSNESVTLTLNASVNRDAVTDDILRDGITNFAEVISADQPDRNSVFGNGDVNEDDADSAILMIARADLSLTKSVDIFNPNRGDTIQYLVTITNANNDPATNVVVRDILPRTLNFQDATPTQGTFDALTGLWTLARLEPNQSATLQINAIVEQSGSVTNVAEIIQSDQIDPDSTPGNANGDEDDLASVEVTPQVVDISVTAAVDNLEPEVDDIITITLTAANADGVSDATGVVVESLLPDGLTLVPPASPQQGSYDPATGQWNIGPLASGASVQLVLTARVDTRGLKTLNAEVTQTDQFDVDSVPGNGDPDEDDQVALEIRAPRVLSKRLFLSR
>NC_005027.1|WP_007324135.1|5789965_5790514_+|hypothetical-protein
MITHHVRIGFAGEIYLARAERRIERGRRVLVRTPRGVELAEVLSVCDDDGTPTTLEILRPTTHNDDLLIERLQRHKVRAVRECQAILAESESSAVLLDVDQLFDGGTLVLHFLGEPDALGRELTDAIVRRYESEVKSIELSDLMQTGCGPGCGTADAGGCGGGCSSCSGCGIASARQKQPLG
>NC_005027.1|WP_011122868.1|5788592_5789888_-|DNA-repair-exonuclease
MSHRRILHAADIHLDSPLQKLDAYEDAPVDEIREASRRALENMTDLAIEEQVDLVVIAGDLYDGDWPDQNTGLFFVKQATRLVNEKIHVAVIRGNHDAANKMTSNLPLPKNPDGSDILLSEKKVDQRVLEDLGIVIHGRSYAKRAETGDMAAEYPSPIGGMFNLGILHTGLSGLDGHDPYAPCSPQQLADKGYDYWALGHIHLRGEHQIKGTAPVVFSGNIQGRHIRESGPKGCILVDVDARNQTQRRFVPLDVVRFETFDANAGEWSHTDELMDAYEDWMNDQLQLAEDRLLVTRVILSGESRLHHQWMREQSNLEASLRATSVTHGHGQVWLERLKIKTSAEADRSNTEQHDANQEGPLQSILSVVEELKSSGGDSEWMANELSPLLKKLPTEFSGDQAPIRLDNTEERHEWIEAATTELLARLQGGKR
>NC_005027.1|WP_011122884.1|5808254_5809544_-|alkaline-phosphatase-family-protein
MTKLCILNVVGLTPKLLRHAPNLAAMGNHRAWTSPVPAVTCTSQATMLTGLSPRDHGIVGNGWLYRDTQEIRFWQQTRTLVQGDVFYDRYETAKMFWWFNQSTTAKYGATPKPHYGCDGSKVFDILDWSGCNLTEKLGPFPFFGFWGPAAGIASSDWIAKATALVMREKQPQLTLCYLPHLDYDFQRLPDHDPARVAEVDAAAAKVIEAAGEIGARVVVVSEYGLVPVDTPIGINQVLRRNDWLKVRRGPFGEIMLPGESDAFAVADHQLAHVYVRHPELIPTVRKTLEETPGIASVVSPGDLQLDHPRSGELIALAEPNAWFTYYYWLDDANAPDFARTVDIHRKPGYDPCELFMTSKLRAAARLAQKKAGLRYKMDVIPLDPKLVRGSHGVLIANHSDGPLVIGPGEPPETMQGFPNYVEQLLASSF
>NC_005027.1|WP_011122885.1|5809697_5811395_+|alanine:cation-symporter-family-protein
MLLSKLARFSLLRIATLVVVLFGTGGVAAFAQEEVTSEEVAEESVVEPALGLDQQVDHFFRPIADTWGSVVFFSVELPGVGPLPLVLILLVGGALFFTIVFGFINLRLFPLAIEVVSGKFDEIEKQGQDIPKGVEVMEVDGDLVDTIRDEGEGEVSHFQALATAVSGTVGLGNIAGVAVAVAAGGPGATFWMVVCGLLGMSTKFVECTLGVKYRDVDANGVVHGGPMYYLKKGLAERGMAPVGKVLGVLFAVFCVGGSFGGGNAFQSNQAAQQIKSLLGLPDTGSSGTIIGLVMAVLVAIVIIGGIKRIAKVTEKVVPLMALMYVIAALGIILMHIQSVPWAIGQVISGAFSLEAGFGGLLGVMVQGFRRAAFSNEAGAGSAAIAHSAVKTRFPASEGIVALLEPFIDTVVICTMTAIVIVLFNADNSFAWGQVDSATSTVLIDGARMGGVDLTSAAFDSVLPGFRYLLTIAIILFAFSTMISWSYYGLQSWKYLFGRSTAADLSYKLLFCLVVVIGAAVSLGSVIEFSDAMIFAMVFPNMIGLFLLFPKVREELSAYLEAIGRK
>NC_005027.1|WP_011122886.1|5811855_5812854_+|hypothetical-protein
MASSDQNVIDEPQIDENSNSTSNGGASQGVGSAGTDGMTEIQKQRLEERERLRTSKFDVVTSLFMSLILFIGAFVLMLFIVWLTMRMPERVKSFPPIEENAAGRADNAEGFERDFEPPGAEEVEELMEPTLQDTIEAVTDAVSSVAGALDTMNTSATASTAGTGKGDSRPPGPEGEGEDIIPRFERWQLNFSAKGLKPYASQLDYYKIELGAIGGSVQGVDYASNLASKPKSRHVDDSESEKRLYFMWTTPSPLMQFDRTLLTQAGINVTGRQMLKFIPEQLENELAHIELEYAREKGHPSVVSIAKTIFQSTASGSGYQFEVVDQRYRKGK
>NC_005027.1|WP_007324221.1|5813101_5813809_+|MotA/TolQ/ExbB-proton-channel-family-protein
MLLAETSLYEIISNSTYLALAAVALWGLYQIVIVWTRVGQKRFKTEEQQDAFMDDVEQMLRAGDYEGVHEYCDGDVRAIPQMIDMAVVNRDEGFKRAKQIMMDRFQRDVMSDLEYRLSWVSTVIKSAPMIGLFGTVFGMMGAFKTLATAEQVEPSALAGDIQVALVTTASGLAIAIPLMLLVATVMIRIAKMEDLLGSGLQRFFEAFKVGLAKSQGAATKNGASSNAEAIAAGVR
>NC_005027.1|WP_007324222.1|5813808_5814297_+|biopolymer-transporter-ExbD
MSQGFIDDDDDDDEPAMPRKKRPEEEMDITPMIDITFLLLIFFVVASKMDPTQTGKIPEATNGLAISAKDSAVIFIEPAGGDSPAILRRYDGSEFSKDEETATSEIVEYVTGELEKSIGTNKNQVMLLGDAEVKVSEVTRVQKIIGDAFQDLEFTYIAVKEQ
>NC_005027.1|WP_007324223.1|5814416_5815151_+|biopolymer-transporter-ExbD
MNERLGGRKIRCPGCDSPITIPEAPAVVEAEPVEVEPIEAEPVAVEAIPAEPVVDAEPELVAVGSAASKAHAAMGDVAAAADSVEPAAFSLDDDDDDALPPRKKRDDGELDMTPMVDVTFLLLIFFMVTASFSLQKSIQMPRQQSELPSTNNDPEETDEKDPVELEIDENGGFLVLAPEWEKETPGKQNLISALKEAVGDNRDGMQLNIKVHENAKLQFLVDGMDAGTIAGFAALQVTEVDGFD
>NC_005027.1|WP_011122891.1|5815263_5818653_+|PQQ-binding-like-beta-propeller-repeat-protein
MVGGFTFINMLANELIDQLERRGLLDQEIIEALREQMSQGGSRVTPEAVAKLLVDNGQLTRFQATKLIGELRSESYDSEAAEVIEGEEDLTAQLIDDEEVAEAVIEDDDPFGDNPVEVEAIEAEPVEVVAEAEVMGDAMDGAPSRGRPSARVKKPETKSTWDSFKIYGYLGIIGFLIIAGGVLWFVLSKGNADEFIALANKQYDSQSYQPAQDAYIAYLDQFGENSQYSSLARTRITMCELFRAEQMTDPVAGLEMAKEKLPTIINEEAMNDERGNLAGFLVDVAENIAREAEAAKETEEKRRLLERLDEQQTLIDNPNYMLSTMKTTLSGRLLQLSEARNRVKREIDRNVRLDATEAAMQSALAEKKTKEAYDERDSLLRDFPELAKDPRLVTLIEEASDIQQTLVKPSAKTPKITNEPASDAAVKSIVLTTRQGDSIPGVEEEVFFLRAGGSVLAFAVDDGRLLWRDYTGQGEDYTPLRLDDGTAVLLSDMANDEIRRCRGEDGEVEWRAKFGEPFVEPVSGRDSILVTMDSGTLVSLDSDSGDVKWSTDLSQELSTPAGLDDTLNRIYIPGSHSNLYVLNARDGKCIESLYLEHDEGTIAVAPVSLLGHVFVIENAGSDYAQVHVLKVDENGENIKIAQSPFRLDGNVVVPPIVQNRRLIVLTDRGQVAVYDIEPTSEKEQVSLIAQQVAAYDKPTLTRMAVGRSQMWITGTRIGRYELQINTGRVVYDWGKNEGDTFIGQPLSLEDVLVHARVLKGTSAIRVTAAEPKTGRELWRTDVGTPIAMITRAPESGFHAVTSQGALFELTAESLSEGSTQGPIENPGANGISMSFQNPIVVDDVRRMLLNQSQKGEALIYDPTRRSEKLRKVTFQLTGPKPTGVATFSGGGLFLPLDTGRAVLMDWQTGSVKGAPFQPASDPTATVQWTNPIKSAADPDQVLIADSRKKLYRLRVGDQIRELSSVDLESPFLGTVAGIESSLLGSVSGPASDYLVGHDQTGLEQTFKKVLDGRIVWGPIAAPSDSNGEIALLITDDQVLRGFSASGEPLFQTQMPEGGLLVDQVVSTGGRWVLTGKDGWLTAVDPASGNVVGTTLLGQPLSAGPLPVGDKLLVPGTEGVVYITNIPGDA
>NC_005027.1|WP_011122892.1|5818658_5821040_+|peptide-ABC-transporter-substrate-binding-protein
MQFQSLMNSNVLHFRRPRCIPRVAQIAFLAVVLFVVCTSSAHAQLLNYAESGRPEAPGLELLQEEPHDLIYFTQKSGGGWVKTRLLDLPRREIPASPTGSLKFSIVGVEQQEFVAKWTDIENIDFWEKRLERETAERIKAGDFVGAYPFLSVLIRDYPARPGLRQLRTEFLWRDAGRRAKNGEYGASLAMLEELRRYAPEYKTQTVLTAIGALTDQLMEQLVSDGKLELGQQLLTRLEKEYRGQDLSSIKKWNARFLSMAEDKRDQALAALEAKKYREARKFSRESIFLKPDIEGGTELVRKVDQIYPLVNVGVLQTATVLDPTRLDNWAARRAGRLLYRVLFEMQGAGPEGGEYEFIFGDTEQSPDRQRFSMFLEPERLPEPLNQVDGFYLADVLADRVKSESPTYFSPWAAAVQAIGLDGPKRIDCILRRPNVLPSALIQVTVDGSWFGGEPGSPTGDYRRDVVEGDVVRYVLKGEPRTELQPREIVEIRTESAADGVSKLLQGEVDVLDQLFPADAVRLSSNRKVRVVKYPLPSVHMLVPCSDHEYLADKTFRRALVYGTNREDILNGELLESLEVPGCRVLSGPFPAGLEDNDPLGYAYDQSIAPRNYEPRLAKLLMTMTAKQMESEASRKKEKPPELKPIRLAFPPENLSRIACEAIRSQWQLLGLEIELVELPVGRAFPDPGTADIAYVSAAVWEPIIDARRVLGPEGMAGSTDQLVGLGLRRLEESKNWRDARDRLLDLHAIAHHELPVLPLWQLVDSYAYSRDLLGVGSDIVSLYQNAEKWRLSQ
>NC_005027.1|WP_011122893.1|5821021_5822908_+|hypothetical-protein
MAVESMSIATSFSNSGPLLRYATTLIALFIALGPSARGQEPNGDAAVQTDPASETDPGAEVETKEVQPFDFDPYRTLIWVASDSPRVCADTLRDDLQKVLDRDFHAVWRTKIEDAPMSVASMAMRVLSEVNFDTLAATDPVIAVKRSHGDAVRIRFAGDVGRYASSILTTTGRMEEINARLAGDPDSPKNAWLRILHAIEGDAVALKDAWAKEDTEAILVSRGMAETLTEPEAKIIVPPITGQVIDAAEAYDKIFIVRIRTATSPMKVESVEFDTLMRYFGDTSRATVSSFNLLPEVVGATLRDVFAPVARIDDAGKSNAVGLVRASGLVTDKNSPALVDVGDVLVPMVRKDDRNGNPISIGPLDWAYLLAKELDGRRVKMDFHAGRAGGLQGRKNARTHRVGLRIRPRKDQTLLRLHAKGDPNQPLIGYEIYEKELEGKSMTFIGRTDWNGRLDVEPTDEQPLRLLYVKNGGAVLARLPMVPGHHEKMVADLGGDDMRLQAESYIRGVQNSIIDLLAIRELFKARIMMRLERGDLEPAEELLEVLRNQPTNERLANDMGKRQSEFIKAIGKNANQQRKVDEMFSVTREMLTKHINPKLVRDLEEAVIVAKENGGKLPPKSDEETDGA
>NC_005027.1|WP_011122894.1|5822908_5825029_-|NAD-dependent-DNA-ligase-LigA
MPQDRFVASDSIASRVQQLVDEINRHNRLYYDDAAPEITDLQYDQLLAELTQLENDHPDLRRPDSPTQLVGGDVVDQLVQVPHRVPMLSIDNTYSREELAAAMERIEKSLEGESVAWTMEYKIDGVAGSIRYENGELTLALTRGNGQVGDDITHNVRTIRELPRSIADAALAHPEVAGGNVPEVLEVRGELYMTDADLADLNVRQTDAGHEPFKNTRNVTAGTIRLLDPKIAASRNIRFFCHGSGELVGVRASDHMTFLQHVQALGIPIAPDVVRFENKEDALQAIAKLELEMPDLPFEIDGIVFKVDSFEQREKLGVRSKSPRWVIAYKFERYEAITTLEAIDVQVGKTGTITPVAYLTPVDIADTTVSRASLHNADEIERLDVRVGDTVVVEKAGKIIPKVVRVEKHARTKPLPKFEFPTHCPQCDEVLTRDEGGVYIRCTNPACPAQLRQRLVYFGSRTGMDIDGLGEEVVDLLLQKELVENYADLYRLNVDELAELTWPRLRKGKGDEMIEVQFGRKNAESLVAGINESRTRGLARVLSSISIRHIGPRVAKLITAKFWNLDLLRSAKAEDLAAIHEIGDRIAESLVKFIHSESGSQTLSDLDAVGVTMSETEPVATPDEEANLPLAGKNIVATGTLQHYTRDEIKARIEELGGRAASSVSKKTDFLIAGEKAGSKLTKAESLGVEVLSEDDFRLRYETEAT

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

370407 : 431110

Acinetobacter_phage(66.67%)

transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_164921338.1\|370407_371088_-\|transposase	transposase	NA	NA	NA	NA
WP_011118029.1\|371238_373908_-	sulfatase-like hydrolase/transferase	NA	NA	NA	NA
WP_164921339.1\|374014_377449_-	family 78 glycoside hydrolase catalytic domain	NA	NA	NA	NA
WP_164921341.1\|377955_378138_-	hypothetical protein	NA	NA	NA	NA
WP_164921275.1\|378136_379307_+\|transposase	IS3-like element ISRba6 family transposase	A0A0P0I4A4	Acinetobacter_phage	5.5e-40	36.7
WP_164921342.1\|380765_381515_-	SGNH/GDSL hydrolase family protein	NA	NA	NA	NA
WP_011118036.1\|381936_384627_+	DUF1553 domain-containing protein	NA	NA	NA	NA
WP_164921343.1\|384632_386105_+	DUF1501 domain-containing protein	NA	NA	NA	NA
WP_011118039.1\|386205_386481_+	hypothetical protein	NA	NA	NA	NA
WP_164921345.1\|386467_387790_-	sulfatase-like hydrolase/transferase	NA	NA	NA	NA
WP_011118042.1\|388251_389658_-	sulfatase	NA	NA	NA	NA
WP_011118043.1\|389660_393461_-	DUF1080 domain-containing protein	NA	NA	NA	NA
WP_011118046.1\|393733_396208_-	family 78 glycoside hydrolase catalytic domain	NA	NA	NA	NA
WP_164922656.1\|396253_396442_-	hypothetical protein	NA	NA	NA	NA
WP_011118048.1\|396868_397759_-	dienelactone hydrolase family protein	NA	NA	NA	NA
WP_164921346.1\|397938_399504_-	PQQ-binding-like beta-propeller repeat protein	NA	NA	NA	NA
WP_164922657.1\|400025_403046_+	AsmA family protein	NA	NA	NA	NA
WP_011118052.1\|403210_404305_+	SLBB domain-containing protein	NA	NA	NA	NA
WP_164922658.1\|404654_406805_-	transcriptional regulator	NA	NA	NA	NA
WP_011118054.1\|406809_407223_-	BlaI/MecI/CopY family transcriptional regulator	NA	NA	NA	NA
WP_011118056.1\|407597_409022_+	sulfatase-like hydrolase/transferase	NA	NA	NA	NA
WP_011118057.1\|409111_411349_+	sulfatase-like hydrolase/transferase	A0A1B3AZ08	Gordonia_phage	7.6e-06	28.0
WP_011118058.1\|411419_412355_+	hypothetical protein	NA	NA	NA	NA
WP_164922659.1\|412504_413953_+	sulfatase-like hydrolase/transferase	NA	NA	NA	NA
WP_164921348.1\|414005_415415_+	sulfatase-like hydrolase/transferase	NA	NA	NA	NA
WP_164922660.1\|415501_416224_+	DUF1080 domain-containing protein	NA	NA	NA	NA
WP_011118063.1\|416394_417333_+	membrane protein	NA	NA	NA	NA
WP_011118064.1\|417531_418773_-	DUF1559 domain-containing protein	NA	NA	NA	NA
WP_007325079.1\|419049_419298_-	hypothetical protein	NA	NA	NA	NA
WP_011118066.1\|419310_420540_-	ACR3 family arsenite efflux transporter	NA	NA	NA	NA
WP_011118068.1\|421116_422328_-\|transposase	IS4-like element ISRba2 family transposase	NA	NA	NA	NA
WP_164921349.1\|422976_424260_+	cation:proton antiporter	NA	NA	NA	NA
WP_011118072.1\|424500_424962_+	hypothetical protein	NA	NA	NA	NA
WP_165447201.1\|425293_425467_-	hypothetical protein	NA	NA	NA	NA
WP_164921247.1\|425823_425976_-	hypothetical protein	NA	NA	NA	NA
WP_011118077.1\|427857_429036_-\|transposase	ISAs1-like element ISRba7 family transposase	NA	NA	NA	NA
WP_164921248.1\|429044_429299_+	hypothetical protein	NA	NA	NA	NA
WP_164922661.1\|430019_430241_+\|transposase	transposase	NA	NA	NA	NA
WP_011118082.1\|430237_431110_+\|transposase	IS3 family transposase	A0A0P0I4A4	Acinetobacter_phage	1.4e-32	34.1

DBSCAN-SWA_2

5210289 : 5284438

uncultured_Caudovirales_phage(25.0%)

transposase,plate

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_164922255.1\|5210289_5210982_-\|transposase	transposase	NA	NA	NA	NA
WP_164922256.1\|5211333_5213163_+	Xaa-Pro dipeptidyl-peptidase	NA	NA	NA	NA
WP_011122425.1\|5213214_5214558_-	hypothetical protein	NA	NA	NA	NA
WP_007328770.1\|5214694_5216233_+\|plate	type VI secretion system baseplate subunit TssK	NA	NA	NA	NA
WP_164922257.1\|5216232_5216877_+	DotU family type IV/VI secretion system protein	NA	NA	NA	NA
WP_011122427.1\|5216910_5218644_+	type VI secretion system protein ImpL	NA	NA	NA	NA
WP_007340532.1\|5218794_5219868_+	type VI secretion system protein TssA	NA	NA	NA	NA
WP_007328775.1\|5219936_5220461_+	type VI secretion system contractile sheath small subunit	NA	NA	NA	NA
WP_007328776.1\|5220508_5222011_+	type VI secretion system contractile sheath large subunit	NA	NA	NA	NA
WP_007328777.1\|5222064_5222544_+	type VI secretion system tube protein Hcp	NA	NA	NA	NA
WP_011122429.1\|5222555_5223110_+\|plate	type VI secretion system baseplate subunit TssE	NA	NA	NA	NA
WP_011122430.1\|5223289_5225191_+\|plate	type VI secretion system baseplate subunit TssF	NA	NA	NA	NA
WP_011122431.1\|5225278_5226328_+\|plate	type VI secretion system baseplate subunit TssG	NA	NA	NA	NA
WP_164922258.1\|5226350_5228345_+	type VI secretion system tip protein VgrG	A0A2H4JCD4	uncultured_Caudovirales_phage	5.7e-21	37.1
WP_011122433.1\|5228427_5229342_+	hypothetical protein	NA	NA	NA	NA
WP_007340539.1\|5229341_5229632_+	PAAR domain-containing protein	NA	NA	NA	NA
WP_011122434.1\|5229635_5234027_+	carboxypeptidase regulatory-like domain-containing protein	NA	NA	NA	NA
WP_011122435.1\|5234043_5234844_+	hypothetical protein	NA	NA	NA	NA
WP_164922956.1\|5235131_5239655_-	VWA domain-containing protein	NA	NA	NA	NA
WP_164922259.1\|5240048_5243330_-	c-type cytochrome	NA	NA	NA	NA
WP_007340546.1\|5243887_5244346_+	hypothetical protein	NA	NA	NA	NA
WP_011122439.1\|5244320_5246186_-	YHYH protein	NA	NA	NA	NA
WP_011122440.1\|5246182_5246920_-	hypothetical protein	NA	NA	NA	NA
WP_011122441.1\|5246920_5247988_-	hypothetical protein	NA	NA	NA	NA
WP_011122442.1\|5247984_5248503_-	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_011122444.1\|5248699_5250529_+	SMP-30/gluconolactonase/LRE family protein	NA	NA	NA	NA
WP_011122446.1\|5250929_5251292_+	hypothetical protein	NA	NA	NA	NA
WP_011122449.1\|5251547_5252279_-	hypothetical protein	NA	NA	NA	NA
WP_164922260.1\|5252585_5254412_+	protein kinase	A0A2H4UVE2	Bodo_saltans_virus	1.4e-21	30.4
WP_011122453.1\|5254744_5255845_+	quinone-dependent dihydroorotate dehydrogenase	NA	NA	NA	NA
WP_164922957.1\|5256072_5256858_+	ThuA domain-containing protein	NA	NA	NA	NA
WP_011122456.1\|5257622_5259401_-	arylsulfatase	NA	NA	NA	NA
WP_164922262.1\|5259535_5259802_-	hypothetical protein	NA	NA	NA	NA
WP_164922263.1\|5260109_5260406_-	hypothetical protein	NA	NA	NA	NA
WP_164922264.1\|5260844_5263304_-	S8 family serine peptidase	NA	NA	NA	NA
WP_164922265.1\|5263360_5264365_-	AAA family ATPase	A0A0U3CC34	Pseudomonas_phage	1.2e-16	32.5
WP_011122463.1\|5264969_5265335_-	phosphotyrosine protein phosphatase	NA	NA	NA	NA
WP_164922266.1\|5265331_5265895_-	exonuclease domain-containing protein	A0A1L3KJF4	Beihai_hepe-like_virus	2.5e-06	27.2
WP_164922267.1\|5265933_5266926_+	hypothetical protein	NA	NA	NA	NA
WP_011122467.1\|5267552_5268920_+	hypothetical protein	NA	NA	NA	NA
WP_051058126.1\|5268913_5269558_-	hypothetical protein	NA	NA	NA	NA
WP_011122473.1\|5271137_5271476_-	histidine triad nucleotide-binding protein	NA	NA	NA	NA
WP_164922268.1\|5271597_5272542_+	DNA repair protein RadC	NA	NA	NA	NA
WP_007327966.1\|5273273_5273591_-	P-II family nitrogen regulator	NA	NA	NA	NA
WP_011122477.1\|5273622_5274642_-	aspartate-semialdehyde dehydrogenase	NA	NA	NA	NA
WP_007327931.1\|5275171_5276314_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_164922270.1\|5276964_5280519_+	circumsporozoite protein- membrane associated protein	NA	NA	NA	NA
WP_007340468.1\|5280589_5281087_+	hypothetical protein	NA	NA	NA	NA
WP_007334446.1\|5281207_5282749_+	YifB family Mg chelatase-like AAA ATPase	NA	NA	NA	NA
WP_011120113.1\|5283121_5284438_+\|transposase	IS4 family transposase	NA	NA	NA	NA

DBSCAN-SWA_3

5580901 : 5593398

uncultured_Caudovirales_phage(14.29%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_164922321.1\|5580901_5582599_+	SulP family inorganic anion transporter	A0A2H4J153	uncultured_Caudovirales_phage	2.4e-20	24.0
WP_007326321.1\|5582626_5583010_+	translation initiation factor	NA	NA	NA	NA
WP_007334317.1\|5582991_5583675_-	SAM-dependent methyltransferase	NA	NA	NA	NA
WP_007334318.1\|5583681_5584935_-	protein kinase	A0A2R8FF19	Brazilian_cedratvirus	3.2e-14	27.2
WP_007334319.1\|5584931_5587514_-	response regulator	A0A1V0SGX0	Hokovirus	2.7e-47	31.7
WP_011122719.1\|5587517_5587892_-	hypothetical protein	NA	NA	NA	NA
WP_007328290.1\|5587905_5589567_-	serine/threonine protein kinase	H2ECD5	Megavirus	9.3e-09	23.0
WP_007328291.1\|5589647_5590382_-	di-trans,poly-cis-decaprenylcistransferase	R9W0U9	Flavobacterium_phage	6.1e-21	43.2
WP_011122720.1\|5590378_5591839_-	glycosyltransferase family protein	F2Y1J7	Organic_Lake_phycodnavirus	6.2e-17	33.6
WP_007328293.1\|5591838_5593398_-	sigma-70 family RNA polymerase sigma factor	A0A2I7SAT0	Vibrio_phage	5.1e-33	33.6

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_005027

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection