CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_006958	Corynebacterium glutamicum ATCC 13032, complete genome	3 crisprs	DEDDh,csa3,cas3,cas9,WYL,PrimPol,DinG	0	2	0	0

Cas Category Instructions

Results visualization

1. NC_006958

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CRISPR-Cas detection and classification

Crispr_ID: NC_006958_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_006958_1

311659-311754

Orphan

Consensus_repeat	Method
TGAAACCAGACACACGTGACAAAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_006958_1

>merge|NC_006958|1|311659-311754|CRISPRCasFinder
TGAAACCAGACACACGTGACAAAAATTGCTAAAACATCTAAGTTTTGGCACGCCTGTTTGGTTTCGAGTCGCTCAAACCAGACACACGTGACAAAA

>NC_006958|1|1|311659-311754|CRISPRCasFinder
TGAAACCAGACACACGTGACAAAA	ATTGCTAAAACATCTAAGTTTTGGCACGCCTGTTTGGTTTCGAGTCGC
TCAAACCAGACACACGTGACAAAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_006958.1\|WP_011013539.1\|307954_308737_+\|endonuclease-III	unknown	unknown	gnl\|CDD\|223255
NC_006958.1\|WP_003863309.1\|305287_305761_+\|MaoC-family-dehydratase	unknown	unknown	gnl\|CDD\|239534
NC_006958.1\|WP_011013544.1\|312905_313457_-\|phage-holin-family-protein	unknown	unknown	gnl\|CDD\|377816
NC_006958.1\|WP_003855827.1\|318491_318692_+\|DUF4244-domain-containing-protein	unknown	unknown	gnl\|CDD\|379429
NC_006958.1\|WP_011013541.1\|309297_310041_+\|CoA-pyrophosphatase	unknown	unknown	gnl\|CDD\|239518
NC_006958.1\|WP_003855829.1\|319038_319338_+\|flp-pilus-assembly-TadE/G-like-family-protein	unknown	unknown	gnl\|CDD\|274799
NC_006958.1\|WP_011013542.1\|310131_311328_+\|MarP-family-serine-protease	unknown	unknown	gnl\|CDD\|367140
NC_006958.1\|WP_011013548.1\|317119_317896_+\|type-II-secretion-system-F-family-protein	unknown	unknown	gnl\|CDD\|227300
NC_006958.1\|WP_011013546.1\|314943_316005_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274798
NC_006958.1\|WP_011013536.1\|304069_305266_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173840
NC_006958.1\|WP_011013545.1\|313621_314464_-\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|319796
NC_006958.1\|WP_011013543.1\|311895_312891_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NC_006958.1\|WP_011013535.1\|303132_304077_+\|4-hydroxyphenyl-beta-ketoacyl-CoA-hydrolase	unknown	unknown	gnl\|CDD\|225070
NC_006958.1\|WP_020948499.1\|305875_306703_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293836
NC_006958.1\|WP_011013540.1\|308744_309305_+\|TlpA-family-protein-disulfide-reductase	unknown	unknown	gnl\|CDD\|239264
NC_006958.1\|WP_011013538.1\|307723_307909_-\|hypothetical-protein	unknown	unknown	unknown
NC_006958.1\|WP_011013547.1\|316001_317135_+\|TadA-family-conjugal-transfer-associated-ATPase	unknown	unknown	gnl\|CDD\|200328
NC_006958.1\|WP_003855810.1\|306778_307462_-\|Crp/Fnr-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223736
NC_006958.1\|WP_003863285.1\|318695_319016_+\|hypothetical-protein	unknown	unknown	unknown
NC_006958.1\|WP_011013549.1\|317892_318468_+\|type-II-secretion-system-F-family-protein	unknown	unknown	gnl\|CDD\|224975

Protein	Function_ID	Function_description	E-value
NC_006958.1\|WP_011013539.1\|307954_308737_+\|endonuclease-III	gnl\|CDD\|223255	COG0177, Nth, Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair].	3.20732e-106
NC_006958.1\|WP_011013548.1\|317119_317896_+\|type-II-secretion-system-F-family-protein	gnl\|CDD\|227300	COG4965, TadB, Flp pilus assembly protein TadB [Intracellular trafficking and secretion].	4.49256e-67
NC_006958.1\|WP_011013544.1\|312905_313457_-\|phage-holin-family-protein	gnl\|CDD\|377816	pfam07332, Phage_holin_3_6, Putative Actinobacterial Holin-X, holin superfamily III. Phage_holin_3_6 is a family of small hydrophobic proteins with two or three transmembrane domains of the Hol-X family. Holin proteins are produced by double-stranded DNA bacteriophages that use an endolysin-holin strategy to achieve lysis of their hosts. The endolysins are peptidoglycan-degrading enzymes that are usually accumulated in the cytosol until access to the cell wall substrate is provided by the holin membrane lesion.	6.93881e-32
NC_006958.1\|WP_003855827.1\|318491_318692_+\|DUF4244-domain-containing-protein	gnl\|CDD\|379429	pfam14029, DUF4244, Protein of unknown function (DUF4244). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 66 and 95 amino acids in length. There is a conserved EYA sequence motif.	1.21917e-15
NC_006958.1\|WP_011013541.1\|309297_310041_+\|CoA-pyrophosphatase	gnl\|CDD\|239518	cd03426, CoAse, Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative stress. CoAse has a conserved Nudix fold and requires a single divalent cation for catalysis. In addition to a signature Nudix motif G[X5]E[X7]REUXEEXGU, where U is Ile, Leu, or Val, CoAse contains an additional motif upstream called the NuCoA motif (LLTXT(SA)X3RX3GX3FPGG) which is postulated to be involved in CoA recognition. CoA plays a central role in lipid metabolism. It is involved in the initial steps of fatty acid sythesis in the cytosol, in the oxidation of fatty acids and the citric acid cycle in the mitochondria, and in the oxidation of long-chain fatty acids in peroxisomes. CoA has the important role of activating fatty acids for further modification into key biological signalling molecules.	6.21532e-53
NC_006958.1\|WP_011013540.1\|308744_309305_+\|TlpA-family-protein-disulfide-reductase	gnl\|CDD\|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	4.94736e-22
NC_006958.1\|WP_003863309.1\|305287_305761_+\|MaoC-family-dehydratase	gnl\|CDD\|239534	cd03450, NodN, NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their legume hosts, a symbiotic process that requires production of Nod factors, which are signal molecules involved in root hair deformation and meristematic cell division. The nodulation gene products, including NodN, are involved in producing the Nod factors, however the role played by NodN is unclear.	1.47997e-80
NC_006958.1\|WP_011013546.1\|314943_316005_+\|hypothetical-protein	gnl\|CDD\|274798	TIGR03815, CpaE_hom_Actino, helicase/secretion neighborhood CpaE-like protein. Members of this protein family belong to the MinD/ParA family of P-loop NTPases, and in particular show homology to the CpaE family of pilus assembly proteins (see ). Nearly all members are found, not only in a gene context consistent with pilus biogenesis or a pilus-like secretion apparatus, but also near a DEAD/DEAH-box helicase, suggesting an involvement in DNA transfer activity. The model describes a clade restricted to the Actinobacteria.	2.11979e-92
NC_006958.1\|WP_011013536.1\|304069_305266_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|173840	cd01151, GCD, Glutaryl-CoA dehydrogenase. Glutaryl-CoA dehydrogenase (GCD). GCD is an acyl-CoA dehydrogenase, which catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and carbon dioxide in the catabolism of lysine, hydroxylysine, and tryptophan. It uses electron transfer flavoprotein (ETF) as an electron acceptor. GCD is a homotetramer. GCD deficiency leads to a severe neurological disorder in humans.	6.49897e-107
NC_006958.1\|WP_011013545.1\|313621_314464_-\|HAD-family-hydrolase	gnl\|CDD\|319796	cd02612, HAD_PGPPase, phosphatidylglycerol-phosphate phosphatase, similar to Escherichia coli K-12 phosphatidylglycerol-phosphate phosphatase C. This family includes Escherichia coli K-12 phosphatidylglycerol-phosphate phosphatase C, PgpC (previously named yfhB) which catalyzes the dephosphorylation of phosphatidylglycerol-phosphate (PGP) to phosphatidylglycerol (PG). This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	2.04883e-74
NC_006958.1\|WP_011013543.1\|311895_312891_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	7.03659e-22
NC_006958.1\|WP_011013535.1\|303132_304077_+\|4-hydroxyphenyl-beta-ketoacyl-CoA-hydrolase	gnl\|CDD\|225070	COG2159, COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only].	2.74268e-86
NC_006958.1\|WP_020948499.1\|305875_306703_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293836	cd16278, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily.Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	5.85899e-64
NC_006958.1\|WP_011013542.1\|310131_311328_+\|MarP-family-serine-protease	gnl\|CDD\|367140	pfam02674, Colicin_V, Colicin V production protein. Colicin V production protein is required in E. Coli for colicin V production from plasmid pColV-K30. This protein is coded for in the purF operon.	1.69959e-18
NC_006958.1\|WP_011013547.1\|316001_317135_+\|TadA-family-conjugal-transfer-associated-ATPase	gnl\|CDD\|200328	TIGR03819, heli_sec_ATPase, helicase/secretion neighborhood ATPase. Members of this protein family comprise a distinct clade of putative ATPase associated with an integral membrane complex likely to act in pilus formation, secretion, or conjugal transfer. The association of most members with a nearby gene for a DEAH-box helicase suggests a role in conjugal transfer.	2.31214e-154
NC_006958.1\|WP_003855810.1\|306778_307462_-\|Crp/Fnr-family-transcriptional-regulator	gnl\|CDD\|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	1.34158e-55
NC_006958.1\|WP_003855829.1\|319038_319338_+\|flp-pilus-assembly-TadE/G-like-family-protein	gnl\|CDD\|274799	TIGR03816, tadE_like_DECH, helicase/secretion neighborhood TadE-like protein. Members of this small, highly hydrophobic protein family occur in a pilus/secretion-like region that usually is next to an uncharacterized DEAH-box helicase, in Actinobacteria. Members show sequence similarity to the TadE-like family described by pfam07811. The function is unknown. [Unknown function, General].	9.82352e-08
NC_006958.1\|WP_011013549.1\|317892_318468_+\|type-II-secretion-system-F-family-protein	gnl\|CDD\|224975	COG2064, TadC, Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion].	1.403e-14

>NC_006958.1|WP_011013542.1|310131_311328_+|MarP-family-serine-protease
MLSPSLVVDAVIVLVMAFALWGGWRQGAFTSLLSTVGVVSGLVVGAAAAPFVMGLTDSTALRFLLAIGTVVLLVGLGNLIGAHLGAAIRDNIKFRSSRTLDSGLGAIFQVLATLIVVWLVAIPLATGLPGTVASGIRDSRILGFVDKYTPQGLDTLPSKIAAMLSESGLPPLISPFTGGSSVEVDAPEINVTNVDLVEAMRPSVIHVMGDAQECSRRLMGSGFVASPDYVVTNAHVVAGTSTVSLDTMIGTRSAEVVFYDPNLDIAVLYSPDLGLDPLPWASTPLDTGDEAIVMGFPQSGPFNASPARVRERIMITGSNIYANGQHEREAYSVRGSIQSGNSGGPMTNEMGEVVGVVFGAAIDGSDTGYVLTAEEVQERIGDITALTQPVDTMQCAVS
>NC_006958.1|WP_011013541.1|309297_310041_+|CoA-pyrophosphatase
MRNYPDLPHDFPGQNTELTPAKAPVWMHRLLDRIHTGRMANPLDGAETLGDTDSEKRAAVLMLFSGSETSFDLPNDASVLLTHRTPTMRSHAGQIAFPGGRIDPTDTNAVDCAFREAWEETGLDRRTATPLAQLNEVHIRATGYPVYPILGHWHTPSPVAVASPHETDEVFDAPLYDLIDPKNRLMVGWREWHGPAFRINDYIIWGFTGGLLSAILDTAGWATEWDTDRIFDLENTLSTSRNNERMR
>NC_006958.1|WP_011013540.1|308744_309305_+|TlpA-family-protein-disulfide-reductase
MTSSAKWSIVGVVAILAVIVALIPQLVGGESAEEAQGETSTSKITTRPDCVASGAAGVDLPCLGGANGVGNELATVVNLWAWWCEPCRAELPIFDEFATTHPELNVIGVHADQNAANGAALLEDLGVNLASYQDDSNLFAGTLGLPGVVPITIVVSPDGNVVDTFPQPFETIDDLETAVAGALQNA
>NC_006958.1|WP_011013539.1|307954_308737_+|endonuclease-III
MGSITPQKRPRVGSHIANKGQETDIGRKRRARRINRTLTVAYPDAHCELDFTNPLELTVATILSAQCTDVRVNQVTPALFKRYPTATDYANADRTELEEFIRPTGFYRNKATSLIGLGEALISLHDGQVPGTLEQLVELPGVGRKTANVVLGNAFGVPGITVDTHFGRLVRRLKLTDEEDPVKVEKVMNELIEKPEWTMFSHRLIFHGRRICHSRRAACGACMLAADCPSFGLEGPSDPFEAQKLIKSDDREHLLKMAGM
>NC_006958.1|WP_011013538.1|307723_307909_-|hypothetical-protein
MTGLLVVIIPLLLMLFAFAMERIESSFLHSNAPQNTEVKLAKDAIGAENLNDGDVQEASAA
>NC_006958.1|WP_003855810.1|306778_307462_-|Crp/Fnr-family-transcriptional-regulator
MEGVQEILSRAGIFQGVDPTAVNNLIQDMETVRFPRGATIFDEGEPGDRLYIITSGKVKLARHAPDGRENLLTIMGPSDMFGELSIFDPGPRTSSAVCVTEVHAATMNSDMLRNWVADHPAIAEQLLRVLARRLRRTNASLADLIFTDVPGRVAKTLLQLANRFGTQEAGALRVNHDLTQEEIAQLVGASRETVNKALATFAHRGWIRLEGKSVLIVDTEHLARRAR
>NC_006958.1|WP_020948499.1|305875_306703_+|MBL-fold-metallo-hydrolase
MEHPAYSQLRPVTPSASVVLCPNPGYSSLEGTNSWVIRAPEDPRSIVIDPGPEDEGHLNVLHSKAEEVGLILLTHRHYDHADGAQRFRQLTNAPVRAMDPSYCAGAEEIHDGEIITIDGVTPQIEVVATPGHTRDSVSYFIWSGVPHESTLEGIVSGDTIAGRHTTMISETDGDLGEYLNSLAILEERGKDIPLLPGHGPDGQDVSSFARKYIERRELRLNQIREVWETRGRDVSMKDLIDAIYDDVDPVLRGAAEQSTHVAIRYLQAQEASASN
>NC_006958.1|WP_003863309.1|305287_305761_+|MaoC-family-dehydratase
MTTSTTPNTIVSFEDAPTLTGQDLGFSQWRTVTQEMVNTFADATDDQQWIHTDPERAKDGPFGGAIAHGFLTLSMIIPFWGELLDVTGVTTKVNYGLDKVRFTSPVKVGSRIRMGAVVREISEVKGNGLHLVADGTIEIEGQERPAVVATFLTRFYA
>NC_006958.1|WP_011013536.1|304069_305266_+|acyl-CoA-dehydrogenase
MRDPIQGAVIPSDLFGFAEVLTEAERAVLLETRRVLEEEVKPYINEAWDKAVFPDEIVQPLQDLQLLDPPALREAGESVRDIFTGFRNFELARCDINVGTYYNASAGLFRTACMVGGSPEQAQRLDAQIKSGEVKGVFALTEPDHGSDIAGGLATTATKDADTGEWIINGEKRWIGGASTADLIATFARDTADNQVKCFLVAPQAEGVSMEIIDRKASLRIMQNAHITYNNVRVSGDARLHNINSFKDVSECLRRMRSDVAWMAVGAQAGAYEAAVKYVRSREQFGRPIAGFQLIQEKLALMLGNLTASLGMMVKLTDQQQAGIFKEENSALAKMFTSLKLRETASWAREICGGNGIILDNDVARFHADAEAVYSYEGTHEINALIVGRAITGVSAFI
>NC_006958.1|WP_011013535.1|303132_304077_+|4-hydroxyphenyl-beta-ketoacyl-CoA-hydrolase
MSNNVVKYECAVDADNIVAVDMHVHLEVDSCGHKSMPADIMAASSKYFKTAERTPSADAIADIYREHKMAAVVFTIDARTQMGHLPNSIDDLVASCARNNDVLIPFGSVDPRTGEDALVEARRQVEELGVRGFKFHPSVQGFDPSAPEFYPLWELLESFGLPCVFHTGQNGMGAGLPGGRGIKLRFSNPMLLDDVAADFPNLTIIMAHPSVPWQDEANSIATHKANVFIDLSGWSPKYFPESLVRQSNNVLSKKVLFGTDFPLITPEKWLAAFANLPLKDEVRPGILKDNAVKVLGLAASTERGSQAEKVVQHA
>NC_006958.1|WP_011013543.1|311895_312891_-|alpha/beta-hydrolase
MAFFSFSTSPLTRLIPGSRSKATGAKRRLSSTIASIERSPGIIALDGPFTHDHVSVRGIRLHLAEAGSPTKPLVLLIHGAFGGWYDYREVIGPLADAGFHVAAIDLRGYGMSDKPPTGYDLRHAAGELSSVIAALGHDDALLVGSDTGASIAWAIASMYPERVRGLISLGAIHPLDMRRAIRRKPHLHVSDLSRLAPFRLPSFLHNLFHFGITSEARREIVNNTSSSYQRSNAFTETVLLRKKALSIDHTITPIIRTNRYLVGSIPSKTVSAPVWLLRTNTRRWEHLANTARTRTTGPFTTIAIPGGYELPYLENPSEFAATIAEFARTTF
>NC_006958.1|WP_011013544.1|312905_313457_-|phage-holin-family-protein
MSNKDGLFTDGNSTFAPKVDSIPLSDVDTSVSGEASIGTLISNATSQMSSLFRAEVELAKTELAGEAKKAAIGGGAFSVAGVIALYSSFFFFFFVAALLSEWIKPWAAFLIVFLFMLVIAAALALFGWRKVKKMGAPKNTIQSVNQLKNLVPGQASEKLEKANKRGLYTSASFHSPGAITGDH
>NC_006958.1|WP_011013545.1|313621_314464_-|HAD-family-hydrolase
MKHPDPAQKVEGTTATTPTKVAAFFDLDKTIIAMSSTYAYGREFMNSGLISPVEALQLSLAQATYMFAGHTSEQMDNTRDQLTAMIRGWEVQQVRSIAEETMHSVVTPTIYAEARELIEHHQELGHDVIIISASVKELVEPIARELGVHKTVTTVLEAHDGMYTGEVLFYCKGDAKAQSILDLAEANNYDLSLSFAYSDSFTDLPMLEAVGNPAAVNPDRALKKIALEQGWKILSFKNPEPLFQMPSTRDVGIGTGVVAGIAAVTAGSIWWMKRARRGSA
>NC_006958.1|WP_011013546.1|314943_316005_+|hypothetical-protein
MNTITHQAILIAVEDPVLHPEAMHVAAATGRPVIETTNLMDISRHFHRTSAVLIDASMASQLSPGKRRDRVFLLDSDPGPSDWKTAMKIHAEQAMLLPAQAGELLSALGRDDKQLPVASGHVIGVAGVVGGTGASTFAAALAKRRAESVTTVLIDADPSSGGIDLLLGIEDVPGARWPDVGLRRGTVQAADVLKALPSTPDEVVVLSTARSNILDPFALSESDVSAAIDCFLSADRSVDVVVDLPHARVHPDIAERLSHLVLVIPAEVRAVAAARARCLELQQLHVSITCVLRHRGWSGLDVAEVEEILGADITAEVGSIQRLAKSVEMHGLTGSLPRVLSSACDAVLGEVAA
>NC_006958.1|WP_011013547.1|316001_317135_+|TadA-family-conjugal-transfer-associated-ATPase
MTDIDLVVENVQRIIATKETPPTSAEIASLIREQAGVISNEDIVMVLRRLRSDSVGVGPLESLLALPGVTDVLVNAHDSVWIDRGQGVEKVDMDLGSEEAVRRLATRLALTCGRRLDDAQPFADGRITRDDGSVLRIHAVLAPLAESGTCISVRVLRQARLSLDDLIQSGTVPEDIAPALRNIINQRRSFLVVGGTGTGKTTLLSAMLTEVPADQRIICIEDTAELHPGHPSTINLVSRQANVEGAGAVSMADLLKQSLRMRPDRIVVGEIRGAEVVDLLAAMNTGHDGGAGTIHANSISEVPARMEALAATGGLDRMALHSQLAAAVDIVLVMKHTPFGRRLAQLGVLRGNPVTTQVVWDLDHGMHEGSEEAWFMP
>NC_006958.1|WP_011013548.1|317119_317896_+|type-II-secretion-system-F-family-protein
MVYALGLLSVAVLISGSRGPGARTRPPTPGNGVHLFALIALFCLATVLFIVVDAYTMIAGIIIATTLFWYLRQTHAAAQRTKQSLQLASFLSLCAGNLRAGVTMVDAMDYALDNTTPDKFLSPTLQTAARQARSGGSGPRVLIDASLPDLQRLGHLWETSERHGIPLVALIDQMRSRISSKQRHGESTRAALQGPQATAVILTVLPLAGMLMGTAMGANPLGLLTGGGIGGFLLVIGVGLDAAGFVLTHKILQSASPS
>NC_006958.1|WP_011013549.1|317892_318468_+|type-II-secretion-system-F-family-protein
MITALVLAAVAMFLGSPNPGVRGGLISPKSGKSLRIRAGPKKLGNADPVDVSADIELFSACLDAGLNTRDAAQVVAHVAAITHRELWTHVVALLSIGVSAPQAFALMAGVDGLDELANLATVSHRSGSALSDGCRNISTSLLASAGDKRTAAAERAGVFIALPLALCFLPAFMIVGLAPVVLSLGTQLINF
>NC_006958.1|WP_003855827.1|318491_318692_+|DUF4244-domain-containing-protein
MSNNLELLRLRTRAILAQDDGLTTVEYALGTLAAAALAAVLYMVVNSDAVSSAFESIISDALSARP
>NC_006958.1|WP_003863285.1|318695_319016_+|hypothetical-protein
MRTKQQREPPELCSDDGSVSIEAALALSSLVIVCGLIIAAMATLAAYLAAVDAAGAAARAHAIGESFEPARGHVDMHEAGGMLTATATIPAPIGQVSASAVFPVEN
>NC_006958.1|WP_003855829.1|319038_319338_+|flp-pilus-assembly-TadE/G-like-family-protein
MTIASAGVASILISLLVVLAWQAGNLVAREQAQVAADVSAVAGAYAFARGELPDAACATAKHTAEANNAQLENCATEGEDLTLTVTVRGQEAHAKAGPL

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Crispr_ID: NC_006958_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_006958_2

2066245-2066454

Orphan

Consensus_repeat	Method
CTGGCTTAGCTGCTGCTGCAGGCTTTG	CRISPRCasFinder

3 spacers

The CRISPR arrays of NC_006958_2

>merge|NC_006958|2|2066245-2066454|CRISPRCasFinder
CTGGCTTAGCTGCTGGCTCTGCCTTCTTAGCTGCATCGCCTGGAGTTGGGCCAGAAAATGCTGGCTTAGCTGCTGCTGCAGGCTTTGGAGCTGAACCTGACTTAGCGGCAGAAGGAGCTGCAGGTGCTGCTGGCTTTGCTGGAGCGCCTGGCTTAGCGGCTGCTGCAGGCTTTGCCTGAACGCCTGGCTTAGGTGCTGCGCCTGGCTTTG

>NC_006958|2|2|2066245-2066454|CRISPRCasFinder
CTGGCTTAGCTGCTGGCTCTGCCTTCT	TAGCTGCATCGCCTGGAGTTGGGCCAGAAAATG
CTGGCTTAGCTGCTGCTGCAGGCTTTG	GAGCTGAACCTGACTTAGCGGCAGAAGGAGCTGCAGGTGCTG
CTGGCTTTGCTGGAGCGCCTGGCTTAG	CGGCTGCTGCAGGCTTTGCCTGAACGC
CTGGCTTAGGTGCTGCGCCTGGCTTTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_006958.1\|WP_003857500.1\|2075847_2077614_-\|proline--tRNA-ligase	unknown	unknown	gnl\|CDD\|236405
NC_006958.1\|WP_011014808.1\|2077701_2078439_+\|peroxide-stress-protein-YaaA	unknown	unknown	gnl\|CDD\|225566
NC_006958.1\|WP_003857486.1\|2059264_2059918_-\|4'-phosphopantetheinyl-transferase-superfamily-protein	unknown	unknown	gnl\|CDD\|225524
NC_006958.1\|WP_006284211.1\|2072991_2074026_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NC_006958.1\|WP_003857497.1\|2072072_2072999_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NC_006958.1\|WP_011014803.1\|2066890_2067229_-\|YlxR-family-protein	unknown	unknown	gnl\|CDD\|225350
NC_006958.1\|WP_011014804.1\|2068458_2068995_-\|ribosome-maturation-factor-RimP	unknown	unknown	gnl\|CDD\|234627
NC_006958.1\|WP_003861694.1\|2063101_2063551_-\|30S-ribosome-binding-factor-RbfA	unknown	unknown	gnl\|CDD\|234787
NC_006958.1\|WP_003861701.1\|2067426_2068425_-\|transcription-termination/antitermination-protein-NusA	unknown	unknown	gnl\|CDD\|237061
NC_006958.1\|WP_011014807.1\|2074022_2075756_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224048
NC_006958.1\|WP_011014797.1\|2055925_2056876_-\|nucleoside-hydrolase	unknown	unknown	gnl\|CDD\|239116
NC_006958.1\|WP_011014796.1\|2052978_2055240_-\|polyribonucleotide-nucleotidyltransferase	unknown	unknown	gnl\|CDD\|131743
NC_006958.1\|WP_011014801.1\|2062097_2063096_-\|bifunctional-oligoribonuclease/PAP-phosphatase-NrnA	unknown	unknown	gnl\|CDD\|223691
NC_006958.1\|WP_011014798.1\|2056965_2057991_-\|bifunctional-riboflavin-kinase/FAD-synthetase	unknown	unknown	gnl\|CDD\|235536
NC_006958.1\|WP_011265853.1\|2055482_2055752_-\|30S-ribosomal-protein-S15	unknown	unknown	gnl\|CDD\|180170
NC_006958.1\|WP_003857487.1\|2059907_2060714_-\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|224327
NC_006958.1\|WP_011014799.1\|2058022_2058916_+\|tRNA-pseudouridine(55)-synthase-TruB	unknown	unknown	gnl\|CDD\|235113
NC_006958.1\|WP_011265854.1\|2060797_2062111_-\|MATE-family-efflux-transporter	unknown	unknown	gnl\|CDD\|240541
NC_006958.1\|WP_011014806.1\|2070289_2071894_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173853
NC_006958.1\|WP_011265856.1\|2069049_2069919_+\|DUF4439-domain-containing-protein	unknown	unknown	gnl\|CDD\|373114

Protein	Function_ID	Function_description	E-value
NC_006958.1\|WP_003857500.1\|2075847_2077614_-\|proline--tRNA-ligase	gnl\|CDD\|236405	PRK09194, PRK09194, prolyl-tRNA synthetase; Provisional.	0
NC_006958.1\|WP_011014808.1\|2077701_2078439_+\|peroxide-stress-protein-YaaA	gnl\|CDD\|225566	COG3022, COG3022, Uncharacterized protein conserved in bacteria [Function unknown].	2.20746e-84
NC_006958.1\|WP_003857486.1\|2059264_2059918_-\|4'-phosphopantetheinyl-transferase-superfamily-protein	gnl\|CDD\|225524	COG2977, EntD, Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism].	1.11116e-85
NC_006958.1\|WP_006284211.1\|2072991_2074026_+\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	5.84446e-93
NC_006958.1\|WP_003857497.1\|2072072_2072999_+\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.37708e-103
NC_006958.1\|WP_011014803.1\|2066890_2067229_-\|YlxR-family-protein	gnl\|CDD\|225350	COG2740, COG2740, Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription].	1.53569e-31
NC_006958.1\|WP_011014804.1\|2068458_2068995_-\|ribosome-maturation-factor-RimP	gnl\|CDD\|234627	PRK00092, PRK00092, ribosome maturation protein RimP; Reviewed.	2.35156e-39
NC_006958.1\|WP_003861694.1\|2063101_2063551_-\|30S-ribosome-binding-factor-RbfA	gnl\|CDD\|234787	PRK00521, rbfA, 30S ribosome-binding factor RbfA.	2.59312e-44
NC_006958.1\|WP_003861701.1\|2067426_2068425_-\|transcription-termination/antitermination-protein-NusA	gnl\|CDD\|237061	PRK12327, nusA, transcription elongation factor NusA; Provisional.	1.55342e-169
NC_006958.1\|WP_011014807.1\|2074022_2075756_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224048	COG1123, COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only].	0
NC_006958.1\|WP_011014797.1\|2055925_2056876_-\|nucleoside-hydrolase	gnl\|CDD\|239116	cd02650, nuc_hydro_CaPnhB, NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. .	1.79416e-140
NC_006958.1\|WP_011014796.1\|2052978_2055240_-\|polyribonucleotide-nucleotidyltransferase	gnl\|CDD\|131743	TIGR02696, polyribonucleotide_nucleotidyltransferase, guanosine pentaphosphate synthetase I/polynucleotide phosphorylase. Sohlberg, et al. present characterization of two proteins from Streptomyces coelicolor. The protein in this family was shown to have poly(A) polymerase activity and may be responsible for polyadenylating RNA in this species. Reference 2 showed that a nearly identical plasmid-encoded protein from Streptomyces antibioticus is a bifunctional enzyme that acts also as a guanosine pentaphosphate synthetase.	0
NC_006958.1\|WP_011014801.1\|2062097_2063096_-\|bifunctional-oligoribonuclease/PAP-phosphatase-NrnA	gnl\|CDD\|223691	COG0618, COG0618, Exopolyphosphatase-related proteins [General function prediction only].	1.3565e-71
NC_006958.1\|WP_011014798.1\|2056965_2057991_-\|bifunctional-riboflavin-kinase/FAD-synthetase	gnl\|CDD\|235536	PRK05627, PRK05627, bifunctional riboflavin kinase/FAD synthetase.	3.39608e-145
NC_006958.1\|WP_011265853.1\|2055482_2055752_-\|30S-ribosomal-protein-S15	gnl\|CDD\|180170	PRK05626, rpsO, 30S ribosomal protein S15; Reviewed.	4.95041e-52
NC_006958.1\|WP_003857487.1\|2059907_2060714_-\|metallophosphoesterase	gnl\|CDD\|224327	COG1409, Icc, Predicted phosphohydrolases [General function prediction only].	8.08372e-32
NC_006958.1\|WP_011014799.1\|2058022_2058916_+\|tRNA-pseudouridine(55)-synthase-TruB	gnl\|CDD\|235113	PRK03287, truB, tRNA pseudouridine synthase B; Provisional.	8.35587e-180
NC_006958.1\|WP_011265854.1\|2060797_2062111_-\|MATE-family-efflux-transporter	gnl\|CDD\|240541	cd13136, MATE_DinF_like, DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	6.94835e-102
NC_006958.1\|WP_011014806.1\|2070289_2071894_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|173853	cd00995, PBP2_NikA_DppA_OppA_like, The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold. This family represents the periplasmic substrate-binding domain of nickel/dipeptide/oligopeptide transport systems, which function in the import of nickel and peptides, and other closely related proteins. The oligopeptide-binding protein OppA is a periplasmic component of an ATP-binding cassette (ABC) transport system OppABCDEF consisting of five subunits: two homologous integral membrane proteins OppB and OppF that form the translocation pore; two homologous nucleotide-binding domains OppD and OppF that drive the transport process through binding and hydrolysis of ATP; and the substrate-binding protein or receptor OppA that determines the substrate specificity of the transport system. The dipeptide (DppA) and oligopeptide (OppA) binding proteins differ in several ways. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Similar to the ABC-type dipeptide and oligopeptide import systems, nickel transporter is comprised of five subunits NikABCDE: the two pore-forming integral inner membrane proteins NikB and NikC; the two inner membrane-associated proteins with ATPase activity NikD and NikE; and the periplasmic nickel binding NikA, which is the initial nickel receptor that controls the chemotactic response away from nickel. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand binding domains of ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	1.04467e-140
NC_006958.1\|WP_011265856.1\|2069049_2069919_+\|DUF4439-domain-containing-protein	gnl\|CDD\|373114	pfam14530, DUF4439, Domain of unknown function (DUF4439). This domain has a ferritin-like fold.	0.000291497

>NC_006958.1|WP_003861694.1|2063101_2063551_-|30S-ribosome-binding-factor-RbfA
MADNARAARMAKRIQTIVASAIERDIKDRRLEFVTITDVTMTGDLHDAKVFYTVRGASIEEEPDLEAAAEALHRARGQLRKIVGQQLGVRFTPTLTYSIDTVPEASAHMEALLDRARKRDEELAKLREGAAPAGDADPYKTSSKSESEE
>NC_006958.1|WP_011014801.1|2062097_2063096_-|bifunctional-oligoribonuclease/PAP-phosphatase-NrnA
MTDNSQFHAASALVQAAHTVSVVGHLRPDADAIGSVAATVAALQQLGKDAVGAIGQLDSMPENLYTIPGASNIKFGDSLPESDLIIVVDCGSIERTGAFESIIVNNPDKVLVVDHHATNPGFGAVNLIDVEAESTTTILYDWFDAMSVQITPDIAHGLYAGLLTDTGCFRWGRPVMHDMAKELMEFGLDIRAISSALLDQTSVDDLRLVGQIVSRIELREAGPYTLAVLVADFDTINGRSRAVVEGLIEMVRAVEGADFGAVFKEYERGVYTVSLRSSNLSVASLAVHLGGGGHIPAAGYTARGTEIEALDTLIEATVTLGESLRSSAHVDV
>NC_006958.1|WP_011265854.1|2060797_2062111_-|MATE-family-efflux-transporter
MSMSNNDFEHESHDVSAKQIFGLAFPALGVLAAMPLYLLLDTAVVGTLGGFELAALGAATTIQAQVTTQLTFLSYGTTARSSRIFGMGDRRGAIAEGVQATWVALFVGLGILTLMLIGAPTFALWLSGDEALAQEAGHWLRVAAFAVPLILMIMAGNGWLRGIQNTKLPLYFTLAGVIPGAILIPIFVAKFGLVGSAWANLIAEAITASLFLGALIKHHEGSWKPSWTVMKNQLVLGRDLIMRSMSFQVAFLSAAAVAARFGTASLAAHQVLLQLWNFITLVLDSLAIAAQTLTGAALGAGTAKVARRVGNQVIKYSLIFAGGLGLVFVVLHSWIPRIFTQDADVLDAIASPWWIMVAMIILGGIVFAIDGVLLGAADAVFLRNASILAVVVGFLPGVWISYALDAGLTGVWCGLLAFILIRLFAVIWRFKSMKWAR
>NC_006958.1|WP_003857487.1|2059907_2060714_-|metallophosphoesterase
MTTTLWAVSDLHAAVKANADPIENIQPKDPSDWLIVAGDVAERTELVLEILARLRRRFAKVIWVPGNHELFSRSADRYQGRDKYSELVEGCRKIDVLTPEDPYLTFGGVTIVPLFTLYDYSFRRPGFTVEQAVQAARDRQVMMTDEFSIAPFVDIRAWCWDRLAYSIKRLSKINGPTILINHWPLVVEPTYQMRWQELALWCGTRHTRGWAERYNAEAVIYGHLHMPGITNVNGVKHIEVSLGYPREWEHWSGQHVWPYPVMEVDNAG
>NC_006958.1|WP_003857486.1|2059264_2059918_-|4'-phosphopantetheinyl-transferase-superfamily-protein
MLDESLFPNSAKFSFIKTGDAVNLDHFHQLHPLEKALVAHSVDIRKAEFGDARWCAHQALQALGRDSGDPILRGERGMPLWPSSVSGSLTHTDGFRAAVVAPRLLVRSMGLDAEPAEPLPKDVLGSIARVGEIPQLKRLEEQGVHCADRLLFCAKEATYKAWFPLTHRWLGFEQAEIDLRDDGTFVSYLLVRPTPVPFISGKWVLRDGYVIAATAVT
>NC_006958.1|WP_011014799.1|2058022_2058916_+|tRNA-pseudouridine(55)-synthase-TruB
MNAPAPKPGLVIVDKPAGMTSHDVVSKLRRAFSTRKVGHAGTLDPMATGVLVVGIERGTRFLAHMVASTKAYDATIRLGAATSTDDAEGEVISTTDASGLDHSTILAEIVNLTGDIMQKPTKVSAIKIDGKRAHERVRDGEEVDIPARPVTVSVFDVLDYHVDGEFYDLDVRVHCSSGTYIRALARDLGNALQVGGHLTALRRTEVGPFTLNDATPLSKLQENPELSLNLDQALTRSYPVLDITEDEGVDLSMGKWLEPRGLKGVHAAVTPSGKAVALIEEKGKRLATVFVAHPNTL
>NC_006958.1|WP_011014798.1|2056965_2057991_-|bifunctional-riboflavin-kinase/FAD-synthetase
MDIWSGLDSVPADLQGSVVTIGVFDGLHRGHQSLIGEAKKQAEELGVPCVMVTFDPHPIAVFLPGKEPTRLAPLDYRLNLAAECGVDAALVIDFTKELAGLSAEEYFTTMIVDTLHARSVVVGENFTFGVNGAGTESTMRELGQKFGVNVTIAPLLHDDDQRICSTLVRDYLDQGEVERANWALGRRYAVRGEVVRGAGRGGKELGYPTANLYLPTSVALPADGVYAGWFTITDDREIDKEISRDIDGTMVPGVRYQTAISVGTNPTFGDERRSVEAFILDQEADLYGHHVMVEFVGHLRDMVKFNGVDELLDAMARDVTNARDILAKDKLLLDADTQPSA
>NC_006958.1|WP_011014797.1|2055925_2056876_-|nucleoside-hydrolase
MSKKAILDIDTGIDDALALAYALGSPELELIGVTTTYGNVLLETGAVNDLALLDLFGAPEVPVYLGEPHAQTKDGFEVLEISAFIHGQNGIGEVELPASESKALPGAVDFLIDSVNTHGDDLVIIATGPMTNLSAAIAKDPSFASKAHVVIMGGALTVPGNVSTWAEANINQDPDAANDLFRSGADVTMIGLDVTLQTLLTKKHTAQWRELGTPAAIALADMTDYYIKAYETTAPHLGGCGLHDPLAVGVAVDPSLVTLLPINLKVDIEGETRGRTIGDEVRLNDPVRTSRAAVAVDVDRFLSEFMTRIGRVAAQQ
>NC_006958.1|WP_011265853.1|2055482_2055752_-|30S-ribosomal-protein-S15
MALTSEQKKSILSEFGLHETDTGSPEAQIAVLTNRINNLTEHLKFHKHDHHSRRGLLLLVGRRRGLLKYLADNNVDRYRDLIARLGLRR
>NC_006958.1|WP_011014796.1|2052978_2055240_-|polyribonucleotide-nucleotidyltransferase
MSDVKYFEDTEFGLIEAVATIDNGDFGTRTIRFETGQLARQADGAVTTYLDDDTMLLATTTASNQPREGFDFFPLTVDVEERMYAAGRIPGSFFRREGRPSTEAILACRLIDRPLRPTFVKGLRNEVQIVVTVMSMNPEDYYDVVAINGASAATRISGLPVSGAVGGVRMALVVDEKHPEGQWVAFPTHAQHEQSVFEIVVAGRLVERKRGNKTFSDVAVMMVEAGASENVVNRVKDGAPAPTEKIVSDGLEAAKPFIDILCRAQEGLAQRVGNAAKEFPLFPPYTDEVYSAVERKVSKKLASLLTLKAKQERDDATNAYMEEIEAELLPKFEASYSSAAEASKEIRAGYNAVMKAIVRRMILTDHFRIDGRGVTDIRDLAVEVELIPRAHGSSLFERGETQILGVTTLDMLKMEQQIDSLAPGDAKRYMHHYNFPPYSTGETGRVGSPKRREIGHGALAERAVLPVIPSREEFPYAIRQVSEALGSNGSTSMGSVCASTLSLYNAGVPLKAPVAGIAMGLVSGEIDGKTEYVALTDILGAEDAFGDMDFKVAGTADFITALQLDTKLDGIPSKVLSDALEQARDARLTILNTMADVINGPDEMSKFAPRITTVKIPVAKIGELIGPKGKNINALTEETGANISIEDDGTVFISAADGASAEAAIEKINALANPQLPKVGERFLGTVVKTTAFGAFVSLLPGRDGLVHISKLGNGKRVEKVDDVVKVGEKIQVEIADIDNRGKISLVPVVEED
>NC_006958.1|WP_011014803.1|2066890_2067229_-|YlxR-family-protein
MFHDDALKASSGQLSRFNPIRIRTCIATRERKPDSELLRVVQSPELPGVILPDPKRRMPGRGAWLTPSIDALDLAEQRRAFGRALRVSTTVDTGHVRTYLAENAGPDFCKED
>NC_006958.1|WP_003861701.1|2067426_2068425_-|transcription-termination/antitermination-protein-NusA
MNIDVQALKAIESEKGIPVPDLLRTIASALLHSYMDNRETVASANLKPRVDIDSTTGTVNVIVSEFDENGELASEYDDTPSNFGRVSARAVRDAIVKSLREAEASRAFDAYADYEGTVVSGIVQADARAAERGIIIVQLGTEADNQDGVLLPAEQIPGEKLKHGDRVKCFVVGVGKGNTDIQINLSRTHPELVRRLFELEIPEVADGSVEIVAISREAGHRSKVAVQAKVKNLNAKGACIGPRGQRVSNIMRELGGEKIDIIDYSEDPATFVGNALAPSKVVNVEVTDLEAQTARVTVPDYQLSLAIGKEGQNARLAARLTGWKIDIHSDID
>NC_006958.1|WP_011014804.1|2068458_2068995_-|ribosome-maturation-factor-RimP
MAFPTTEILSALIEPLAASHKFDLEGLKVTKAGPKSAVAIKVDSDSRPDLDQLEVFSQEIGELFDAAEQRGELNFGAGYTLEVSTPGVDNPLTLPRHWRRNRGRLVALDQDGKKRVARIGALNDAETHVVLIERNKKLLEVTTLELAHSPRAVVEIEFAKPAQDETALAESTFDEATA
>NC_006958.1|WP_011265856.1|2069049_2069919_+|DUF4439-domain-containing-protein
MRRRIPSVLGVSLLAAFLVACTPSPNPNAALAQMYQDALFDSQAMSEAEPELATLRSQHADELLAEIRRICGFDEGQVPESCQVTVPAIAILPTDDPEKYVNDSQALILDNLDDIPEDSVALVVEQYIAQAEFAEGSEVSVPVDLELTEAELAAAKDLADREFSAAWSLGVALAQLPETDREEVETAISNHHDRASQLQIITSGTTPAPGYVSELPDPTDETSARSNIETVENNVTQAWHAAASAATTDAWRVFCAHIAGDTARELTLIDVSLQFHCQFFKPNPLHNFL
>NC_006958.1|WP_011014806.1|2070289_2071894_+|ABC-transporter-substrate-binding-protein
MTLKKSLAVTTAAALALSLAACSSDSSSDSSSSSSGSEGGDNYVLVNGTEPQNPLVPGNTNEVGGGRIVDSIFSGLVYYDVDGSPVNDVAESIELEGDKTYRITIKDGQTFTDGTPVTAESFVNAWNYNVANSTLSSYFFESILGYEEGVESMEGLQVVDDTTFTVELTQPESDFPLRLGYSAFFPLPESAFDDMDAFGENPIGNGPYKLQEWNHNQDATIVPNADYTGGRQAQNDGVKFIFYPTFDSAYADLLSDNLDVLDAIPDSAFSSFEDELSGRSINQPSAVFQSFTIPESLEHFSGEEGVLRRQAISLAVNRDEITQTIFEGTRTPATDFTSPVIDGHSDSLQGADVLTYDPERAQELWAQADEISPWSGEFSISYNADGGHQAWVDATANSIRNTLGIDAIGNPYPDFKSLRDDVTNRTINGAFRTGWQADYPSLGNFLGPLYGTGAGSNDGDYSNPDFDAKLAEAANAADVDASTPLYNEAQEILLQDLPAIPTWYSNAVGGYSTNVDNVEFQWNSQPAYYQITKN
>NC_006958.1|WP_003857497.1|2072072_2072999_+|ABC-transporter-permease
MLRYVGRRLLQMIPVFFGATLLIYALVFLMPGDPVQALGGDRGLTEAAAEKIRQEYNLDKPFIVQYLLYIKGIFVLDFGTTFSGQPVIDVMARAFPVTIKLAIMALLFESILGIIFGVIAGIRRGGIFDSTVLVLSLIVIAVPTFVIGFVLQFLVGVKWGLLPVTVGSNTSITALIMPAVVLGAVSFAYVLRLTRQSVSENLRADYVRTARAKGMSGFNVMNRHVLRNSLIPVATFLGADLGALMGGAIVTEGIFGINGVGGTLYQAILKGEPTTVVSIVTVLVIVYIIANLLVDLIYAVLDPRIRYA
>NC_006958.1|WP_006284211.1|2072991_2074026_+|ABC-transporter-permease
MPNNEFHTNHSLGQDDQTPDQAHFFPQGRGEALVRPGQEHFIAATDETGLGAVDAVADDSAPTSMWGEAWRDLRRRPLFWVSAVLIILALLLAAVPQLFTSTDPQFCVLANSLDGPQSGHPFGFDRQGCDIFARTVYGARASVAVGVLTTLLVALIGTVFGALAGFFGGIMDTILSRITDMFFAIPLVLAAIVVMQMFKEHRTIVTVVLVLGLFGWTNIARITRGAVMTAKNEEYVTSARALGASKAKILLSHIMPNAAAPIIVYATVALGTFIVAEATLSFLGIGLPPSIVSWGADIAKAQTSLRTQPMVLFYPAMALALTVLSFIMMGDVVRDALDPKSRKR
>NC_006958.1|WP_011014807.1|2074022_2075756_+|ABC-transporter-ATP-binding-protein
MTTNIPQTPNHEGEQPLLELKDLKISFTSSTGVVDAVRGANLTIYPGQSVAIVGESGSGKSTTAMSIIGLLPGTGKVTEGSIMFDGQDITGLSNKQMEKYRGSEIGLVPQDPMTNLNPVWRIGTQVKESLRANHVVPGSEMDKRVAEVLAEAGLPDAERRAKQYPHEFSGGMRQRALIAIGLAARPKLLIADEPTSALDVTVQRQILDHLETLTKDLGTAVLFITHDLGLAAERAEHLVVMHRGRIVESGPSLKILRNPQHPYTQRLVKAAPSLASARIQSAQEQGIESAELLSATAVAEGTIPEMEEKVIEVKNLTREFDIRGARGDKKKLKAVDDVSFFVRKGTTTALVGESGSGKSTVANMVLNLLEPTSGEVLYNGTDLTSLSHKEIFQMRRKLQVVFQNPYGSLDPMYSIYRCIEEPLTIHKVGGDRKAREARVAELLDMVSMPRSTMRRYPNELSGGQRQRIAIARALALNPEVIVLDEAVSALDVLVQNQILTLLAELQQELKLTYLFITHDLAVVRQTADDVVVMQKGRIVEKGRTDDIFNDPQQHYTRDLINAVPGLGIELGTGENLV
>NC_006958.1|WP_003857500.1|2075847_2077614_-|proline--tRNA-ligase
MITRLSTLFLRTLREDPADAEVPSHKLLVRAGYIRRVAPGIYSWLPLGLRAVRNIEAVVREEMDAIGGQELLFPALLPREPYETTQRWTEYGDSLFRLKDRKGADYLLGPTHEEMFAATVKDLYNSYKDFPVTLYQIQTKYRDEERPRAGVLRGREFVMKDSYSFDISDAGLDESYAKHRAAYQRIFDRLGLEYAICQATSGAMGGSASEEFLAVSENGEDTFVRSTSGNYAANVEAVVTQPGVERDIEGLPEAVTYETPVSETIDALVDWANSIDVQIEGREVTAADTLKCIVVKVREPGAEEAELTGILLPGDREVDMKRLEASLEPAEVELAVESDFADNPFLVKGYVGPVGLAKNGVKVLADPRVVTGTSWITGADEKERHVVGLVAGRDFTPDGFIEAAEIKEGDPAPAGEGTLTLARGIEIGHIFQLGRKYTEAFDVQILDENGKRAIPTMGSYGLGVTRLLAVLAEQRHDDAGLNWSVEVAPYQVHVVAANKDAAAIEAAERFAAELSAAGLDVLFDDRPKVSPGVKFKDAELLGMPFALILGRGYAEGKVELRVRGGEKSELDADQAVAQIVEMVAQARN
>NC_006958.1|WP_011014808.1|2077701_2078439_+|peroxide-stress-protein-YaaA
MLIVLPPSETKTHGGSGKPLDFHHLSFPSLTKARQTILADLQALEVDEALKVLGISEKLRPEAESNRALETSPTMPAIFRYSGVLYDALDAATLPEKALERLAIGSALFGVIHATDPIPHYRLSGGTKLPTKSGELPTMKARWGTSISEALIDVNQLVIDLRSGTYQQLGRVKDAVTVRVESVMEDGSRKVVSHFNKHYKGELARVLALSEKEAHNAEDVMSIAQAAGLVVEENPNHKETLTLVV

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Crispr_ID: NC_006958_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_006958_3

2897014-2897112

Orphan

Consensus_repeat	Method
TGGTCGGGCCACGCGTTTGTGGTGGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_006958_3

>merge|NC_006958|3|2897014-2897112|CRISPRCasFinder
TGGTCGGGCCACGCGTTTGTGGTGGATTTTTGCACCTTGCAGCCAGTTTGATGCGAAAATTCGTTCGGTTTAATGGTCGGGCCACGCGTTTGTGGTGGA

>NC_006958|3|3|2897014-2897112|CRISPRCasFinder
TGGTCGGGCCACGCGTTTGTGGTGGA	TTTTTGCACCTTGCAGCCAGTTTGATGCGAAAATTCGTTCGGTTTAA
TGGTCGGGCCACGCGTTTGTGGTGGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_006958.1\|WP_011015341.1\|2893593_2894601_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NC_006958.1\|WP_003862899.1\|2889236_2889512_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|181179
NC_006958.1\|WP_003853677.1\|2900855_2901614_-\|multidrug-ABC-transporter-permease	unknown	unknown	unknown
NC_006958.1\|WP_011015348.1\|2904647_2905682_+\|glutamate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270408
NC_006958.1\|WP_003853692.1\|2894627_2895419_+\|exodeoxyribonuclease-III	unknown	unknown	gnl\|CDD\|197320
NC_006958.1\|WP_003853711.1\|2889512_2889893_+\|monovalent-cation/H(+)-antiporter-subunit-G	unknown	unknown	gnl\|CDD\|183613
NC_006958.1\|WP_011015345.1\|2901606_2902539_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213235
NC_006958.1\|WP_003862874.1\|2908619_2909813_-\|acetate-kinase	unknown	unknown	gnl\|CDD\|234680
NC_006958.1\|WP_003853699.1\|2892794_2893007_-\|DUF3263-domain-containing-protein	unknown	unknown	gnl\|CDD\|378688
NC_006958.1\|WP_011266002.1\|2903174_2904647_+\|hypothetical-protein	unknown	unknown	unknown
NC_006958.1\|WP_011266001.1\|2902560_2903055_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|239217
NC_006958.1\|WP_011015349.1\|2905671_2908140_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|319004
NC_006958.1\|WP_003853704.1\|2890934_2892065_-\|glutamate--cysteine-ligase	unknown	unknown	gnl\|CDD\|237408
NC_006958.1\|WP_003853689.1\|2895425_2896928_+\|PLDc-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|234967
NC_006958.1\|WP_003862894.1\|2893022_2893604_+\|peptide-deformylase	unknown	unknown	gnl\|CDD\|237227
NC_006958.1\|WP_003862889.1\|2897258_2898455_-\|multidrug-effflux-MFS-transporter	unknown	unknown	gnl\|CDD\|340878
NC_006958.1\|WP_011015340.1\|2892123_2892789_-\|LytR-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|379163
NC_006958.1\|WP_172820770.1\|2898875_2900015_+\|Na/Pi-symporter	unknown	unknown	gnl\|CDD\|224202
NC_006958.1\|WP_011015343.1\|2900011_2900854_-\|PhzF-family-phenazine-biosynthesis-protein	unknown	unknown	gnl\|CDD\|223461
NC_006958.1\|WP_003853708.1\|2890328_2890928_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669

Protein	Function_ID	Function_description	E-value
NC_006958.1\|WP_011015341.1\|2893593_2894601_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	2.65547e-10
NC_006958.1\|WP_003862899.1\|2889236_2889512_+\|hypothetical-protein	gnl\|CDD\|181179	PRK07948, PRK07948, putative monovalent cation/H+ antiporter subunit F; Reviewed.	4.78942e-38
NC_006958.1\|WP_011015348.1\|2904647_2905682_+\|glutamate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270408	cd13690, PBP2_GluB, Substrate binding domain of ABC glutamate transporter; the type 2 periplasmic binding protein fold. This group includes periplasmic glutamate-binding domain GluB from Corynebacterium efficiens and its related proteins. The GluB domain belongs to the type 2 periplasmic binding protein fold superfamily (PBP2), whose many members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.54629e-75
NC_006958.1\|WP_003853692.1\|2894627_2895419_+\|exodeoxyribonuclease-III	gnl\|CDD\|197320	cd09086, ExoIII-like_AP-endo, Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases. This subfamily includes Escherichia coli ExoIII, Neisseria meningitides NExo,and related proteins. These are ExoIII family AP endonucleases and they belong to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds. AP endonucleases participate in the DNA base excision repair (BER) pathway. AP sites are one of the most common lesions in cellular DNA. During BER, the damaged DNA is first recognized by DNA glycosylase. AP endonucleases then catalyze the hydrolytic cleavage of the phosphodiester bond 5' to the AP site, and this is followed by the coordinated actions of DNA polymerase, deoxyribose phosphatase, and DNA ligase. If left unrepaired, AP sites block DNA replication, and have both mutagenic and cytotoxic effects. AP endonucleases can carry out a variety of excision and incision reactions on DNA, including 3'-5' exonuclease, 3'-deoxyribose phosphodiesterase, 3'-phosphatase, and occasionally, nonspecific DNase activities. Different AP endonuclease enzymes catalyze the different reactions with different efficiencies. Many organisms have two AP endonucleases, usually one is the dominant AP endonuclease, the other has weak AP endonuclease activity. For example, Neisseria meningitides Nape and NExo, and exonuclease III (ExoIII) and endonuclease IV (EndoIV) in Escherichia coli. NExo and ExoIII are found in this subfamily. NExo is the non-dominant AP endonuclease. It exhibits strong 3'-5' exonuclease and 3'-deoxyribose phosphodiesterase activities. Escherichia coli ExoIII is an active AP endonuclease, and in addition, it exhibits double strand (ds)-specific 3'-5' exonuclease, exonucleolytic RNase H, 3'-phosphomonoesterase and 3'-phosphodiesterase activities, all catalyzed by a single active site. Class II AP endonucleases have been classified into two families, designated ExoIII and EndoIV, based on their homology to the Escherichia coli enzymes ExoIII and endonuclease IV (EndoIV). This subfamily belongs to the ExoIII family; the EndoIV family belongs to a different superfamily.	1.12558e-104
NC_006958.1\|WP_003853711.1\|2889512_2889893_+\|monovalent-cation/H(+)-antiporter-subunit-G	gnl\|CDD\|183613	PRK12592, PRK12592, putative monovalent cation/H+ antiporter subunit G; Reviewed.	2.61795e-74
NC_006958.1\|WP_011015345.1\|2901606_2902539_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213235	cd03268, ABC_BcrA_bacitracin_resist, ATP-binding cassette domain of the bacitracin-resistance transporter. The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multi-enzyme complex BcrABC. Bacitracin has potent antibiotic activity against gram-positive bacteria. The inhibition of peptidoglycan biosynthesis is the best characterized bacterial effect of bacitracin. The bacitracin resistance of B. licheniformis is mediated by the ABC transporter Bcr which is composed of two identical BcrA ATP-binding subunits and one each of the integral membrane proteins, BcrB and BcrC. B. subtilis cells carrying bcr genes on high-copy number plasmids develop collateral detergent sensitivity, a similar phenomenon in human cells with overexpressed multi-drug resistance P-glycoprotein.	1.37782e-94
NC_006958.1\|WP_003853699.1\|2892794_2893007_-\|DUF3263-domain-containing-protein	gnl\|CDD\|378688	pfam11662, DUF3263, Protein of unknown function (DUF3263). This family of proteins with unknown function appears to be restricted to Actinobacteria.	3.49121e-25
NC_006958.1\|WP_003862874.1\|2908619_2909813_-\|acetate-kinase	gnl\|CDD\|234680	PRK00180, PRK00180, acetate kinase A/propionate kinase 2; Reviewed.	0
NC_006958.1\|WP_011266001.1\|2902560_2903055_-\|NUDIX-hydrolase	gnl\|CDD\|239217	cd02883, Nudix_Hydrolase, Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ for their activity. Members of this family are recognized by a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolase include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance and "house-cleaning" enzymes. Substrate specificity is used to define child families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required. This superfamily consists of at least nine families: IPP (isopentenyl diphosphate) isomerase, ADP ribose pyrophosphatase, mutT pyrophosphohydrolase, coenzyme-A pyrophosphatase, MTH1-7,8-dihydro-8-oxoguanine-triphosphatase, diadenosine tetraphosphate hydrolase, NADH pyrophosphatase, GDP-mannose hydrolase and the c-terminal portion of the mutY adenine glycosylase.	5.79279e-16
NC_006958.1\|WP_011015349.1\|2905671_2908140_+\|serine/threonine-protein-kinase	gnl\|CDD\|319004	pfam16918, PknG_TPR, Protein kinase G tetratricopeptide repeat. This domain is found at the C-terminus of protein kinase G and contains a tetratricopeptide repeat (TPR).	3.85826e-95
NC_006958.1\|WP_003853704.1\|2890934_2892065_-\|glutamate--cysteine-ligase	gnl\|CDD\|237408	PRK13517, PRK13517, glutamate--cysteine ligase.	0
NC_006958.1\|WP_003853689.1\|2895425_2896928_+\|PLDc-N-terminal-domain-containing-protein	gnl\|CDD\|234967	PRK01642, cls, cardiolipin synthetase; Reviewed.	2.53007e-117
NC_006958.1\|WP_003862894.1\|2893022_2893604_+\|peptide-deformylase	gnl\|CDD\|237227	PRK12846, PRK12846, peptide deformylase; Reviewed.	6.52209e-77
NC_006958.1\|WP_003862889.1\|2897258_2898455_-\|multidrug-effflux-MFS-transporter	gnl\|CDD\|340878	cd17320, MFS_MdfA_MDR_like, Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	5.09638e-100
NC_006958.1\|WP_011015340.1\|2892123_2892789_-\|LytR-C-terminal-domain-containing-protein	gnl\|CDD\|379163	pfam13399, LytR_C, LytR cell envelope-related transcriptional attenuator. This family appears at the C-terminus of members of the LytR_cpsA_psr, pfam03816, family.	0.00157384
NC_006958.1\|WP_172820770.1\|2898875_2900015_+\|Na/Pi-symporter	gnl\|CDD\|224202	COG1283, NptA, Na+/phosphate symporter [Inorganic ion transport and metabolism].	3.2277e-94
NC_006958.1\|WP_011015343.1\|2900011_2900854_-\|PhzF-family-phenazine-biosynthesis-protein	gnl\|CDD\|223461	COG0384, COG0384, Predicted epimerase, PhzC/PhzF homolog [General function prediction only].	2.05094e-100
NC_006958.1\|WP_003853708.1\|2890328_2890928_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.28371e-06

>NC_006958.1|WP_003853689.1|2895425_2896928_+|PLDc-N-terminal-domain-containing-protein
MIFQINLESWQTVGLIIDYTIKIIAIGYVPEGRRPSSSTAWLLAILLLPYVGLPLFLLMGSPYINRRRHRIQQEINDLIEDVHDDVPDIPTGMDVSAEVESVIKLNRRLTRMPAVTGGNNGFYSDYRESLKRMTAAIDEAEEYIYVEIYIMAWDSYTQPFFAALERAHNRGVKVRLLFDHVGSWKYPGYHRLKKELNRMGFAWYLMLPLQPWRRRFRRPDLRNHRKMLIIDGHTAFMGSQNLIAPSYLQKKNIKLGREWKDLMVELTGPIVSSMEMIFAGDWYVESNEALDIRDHAEAHGYIGNTQKDSATNLVQLIPSGPGYTTEPNLRMFNSIVHHAKERLILCSPYFIPDESLLEAVTSACYRGVTVELFVSEQADQFAIDHAQSSYYQALLEAGVKIYQFPKPDVLHTKYMIADPDDTTGNEALGVLGSSNLDIRSFGLNYEISLMIAKGNLIHELNALTDRYRTVSFKLTLDKWNQRSWRRRYVDNVMRLTSALQ
>NC_006958.1|WP_003853692.1|2894627_2895419_+|exodeoxyribonuclease-III
MRIVNWNVNSARTRVDRMVDFLLRHDVDVLAVQETKCKDEQFPTERFTEIGYEVAHFGLNQWNGVAIISRVGIENVETHFPAQPGFNKDITKEQSIEARAIGARCGGVQVWSLYVPNGREIADPHYDYKLRWLFSLRNYVIDTLEYRPEEKLVLLGDFNIAPTDIDVWDIAAFEGKTHVTEPERAAFDGLIEAGLKETTPGPGTYTYWDYKGARFLKGEGMRIDFQLASPALAATAGETFVDVEERSGTGASDHAPVIVDYKV
>NC_006958.1|WP_011015341.1|2893593_2894601_+|GNAT-family-N-acetyltransferase
MTPSLPRFRSQKPAVGDRVVARRRIPGANVHWTDVIGHVIGVDPLVVRPQSVGGMPSDAEEIVIPDDQLEVIKILSPRTIRNSDIRAVEVATAKAFPGLVNEWHDGWLLRAGDGIAERSNSASPLGPSVGFEPVPMEDISRFYARHDLPVKLHIPERIGRPAQKVIDADPQKWVMGPEILVMTKSLDHVESHELPGGLEFSVDKQPDQEWLGMYHFRGQALPAHALELLRTQIEGRMGFGRLTTPAGQTVAITRATITAAEERIFLGYSAVEVDPAFRRQGLGTALGSRIQEWGAEQHAQEAYLQVVAHNEAGIGLYQKLGFSEHHRHRYAERKF
>NC_006958.1|WP_003862894.1|2893022_2893604_+|peptide-deformylase
MTVRPIVIHGDPVLHNPTQLVTEDVSELQELIADMYETMDVANGVGLAANQIGVSKRIFVYDCPDDEGVMHKGCFINPVLETSEIPETMPADDGSDEEGCLSVPGEGFPTGRAHWAKVTGLNEKGEEVSVEAEGFLARCFQHEVGHLDGFLYTDVLIGRWKRMAKKAIKANGWTEPGLTWMPGEDEDPFGHDA
>NC_006958.1|WP_003853699.1|2892794_2893007_-|DUF3263-domain-containing-protein
MLSADDLTLLEFEAHAPHAIGAKEEAIRATFGISPVRYYQRLNVIIDTPEAMKVNPTLVSRLRRRAGKID
>NC_006958.1|WP_011015340.1|2892123_2892789_-|LytR-C-terminal-domain-containing-protein
MTSDMQNSPQHSATPSEEKQGGLPMRGLAMILIAVAVLLAAWALWSMQGKDDTSTTSAGQTQSTETNAGTIAESSGSSDSEQASAEPGTSEETSAEQPAADGEAANAAGAAAAGGASSANGNSTPVNTLYVLNNSTVPQLAARVADSLSGDYQKVESGNLPDTIIPQNTVYFTAGNTEAEKAARELADRVSGVAMERSDALPTETEGKDALVLVLVQDVAL
>NC_006958.1|WP_003853704.1|2890934_2892065_-|glutamate--cysteine-ligase
MGIEFKRSPRPTLGVEWEIALVDPETRDLAPRAAEILEIVAKNHPEVHLEREFLQNTVELVTGVCDTVPEAVAELSHDLDALKEAADSLGLRLWTSGSHPFSDFRENPVSEKGSYDEIIARTQYWGNQMLIWGIHVHVGISHEDRVWPIINALLTNYPHLLALSASSPAWDGLDTGYASNRTMLYQQLPTAGLPYQFQSWDEWCSYMADQDKSGVINHTGSMHFDIRPASKWGTIEVRVADSTSNLRELSAIVALTHCLVVHYDRMIDAGEELPSLQQWHVSENKWRAARYGLDAEIIISRDTDEAMVQDELRRLVAQLMPLANELGCARELELVLEILERGGGYERQRRVFKETGSWKAAVDLACDELNDLKALD
>NC_006958.1|WP_003853708.1|2890328_2890928_-|alpha/beta-hydrolase
MVESQHIIFIPESQQTPDEFTEVVNEIPAGIKPRIVPWSGSVSAGVQAVESILDREEIRRVILVGAGTGAGVALEIAKNQPRRVERLVLDSPLVTFDEKQLKGMSTALKMMPGFFFRKKNKKDLLQQVEEARTAVPMGFSEITMPTLIIRGSAAKAGIDSDLEKQIPSARATTIIGANWLTYTTHGRQTGAAIAEFLAQ
>NC_006958.1|WP_003853711.1|2889512_2889893_+|monovalent-cation/H(+)-antiporter-subunit-G
MTLQLFTDIVSLVFILSGAFLSFSASIGLIRFKDTMSRVHAMTKPQTTGLILTVVGAIIRILGHEHFDQSQRSDLGVLVLLVLFALLTSPVTAQRVGRVSRREGLYGAKDDMSDNQAPAELKPKKS
>NC_006958.1|WP_003862899.1|2889236_2889512_+|hypothetical-protein
MDNTLYTAGLTIAAAFFMLSFIFTIYRIIVGPNSIDRLLGLDGTVSMIQCSMATYICWTLDTTVTNFMMVIALLGFISSVSVARFRKRDGA
>NC_006958.1|WP_003862889.1|2897258_2898455_-|multidrug-effflux-MFS-transporter
MQKKQQLSTALIMGLALLSASSALATDMYLPAMPGIAEDLGTTAPMVQLTLSSFMAGMAIGQLIIGPLSDQLGRKGLLVAGAVAALVASVVCALAPSISVLVIARLVQGLGGGACVVIARAIVPDLERGQKAAHAFALLMIIQGIAPVVAPLIGGVLVGPFGWRGIFWALALVNFAQLLVALLQIKESKPVEERTAAGLGGMLSNYVFVLKNPQFLAYVFTLGLSFGAMFSYISASPFVLQNQMGIPVLLYSIIFGVNAFGLIVGGMVNRRLLQRIHPHRIMQTVLASFTVLCALLLIEVLFINWIPLFLLLLFLIVSHIPMVMANATALGTEVVRSRAGSGSAILGFVQFTMGALVSSLVGLGSDKALTMGIAMTACALLACGCAYLAGRKGIPEMK
>NC_006958.1|WP_172820770.1|2898875_2900015_+|Na/Pi-symporter
MRWLLVLLSILVIIIGINLILDGVYGFGTFSTTQMYQVAKDPLIGVLIGILATALVQSSTTTTTLTVTAVGTGIVSVPVAIPIILGANIGTTITAMLVAFSYVGERREFKRAFTVAAMHVWFNVLVILVLFVVELLFHPFRTISGAIATEITLTTGGSLPTSGVMTKIFDPPTQLLGMNGLIGSIGNPSISAIVCLVVGTILILISVRAMSSQIRTITAATVTSIMDKVINPENSPKATILSNFWSFILGVLFTLMVTASSVTVASMQPVAASGVVKQKPLLGVILGANVGTTVTAMFATFAIVSDQGEFAIQAALIHLIVNFTGALLVLCIPQLANVIIHLAEKTANLTARSYSITLATIVTAYVLVPSAVLMIYFFI
>NC_006958.1|WP_011015343.1|2900011_2900854_-|PhzF-family-phenazine-biosynthesis-protein
MPSKISRPYYQVDVFSSEPFMGNPLAVIADADDLSAEQMARIARWTNLSETTFLLKPTQEGADYRVRIFTPTGELPFAGHPTLGTAHVFRELHGEQGTQLVQECVAGLVAVRAIDGPASGLAFQAPPTLKDGPLDASDLDAACEALGISPDFIRAHQWVDNGPGWAVVELPSAQHVLDLEPDFSAHPTLKLGVIGAYPEGAPHAFEVRAFAQGIGEDPVTGSLNASIAQWLHRDGRAGEGYLASQGTAIGRAGEIHISIESHAIWVGGSVTTIFQGTAEF
>NC_006958.1|WP_003853677.1|2900855_2901614_-|multidrug-ABC-transporter-permease
MINTIRSEWTKLVTTKSFWWTTALILVFSLGYAALTGSLATGESFASLFLLAGSTVTGLYLLGFVVIMIQSIMMFTTEFRFGYQTQTFLATPKRWVVAVSKWLLYLVFAVVLTFITVILCFYLAKALASDTASSTLVVWEDTQARRIMWQYPLAAALLVTFCSGIALLLRQTAGAVALVLMWHFAIENLLSFLPRIGEYVGKYGPFTNLYAFITDYQSIDPGWSTTMGAVYFGAWAFVLFALGIVVLEKKDA
>NC_006958.1|WP_011015345.1|2901606_2902539_-|ABC-transporter-ATP-binding-protein
MINVEGLTKQYGQVRAVDDLSFEVKPGIVTGFLGPNGAGKSTTMRLILGLDNPTAGHATIEGQPYRSLKNPLTKVGALLDAKATHPNRTAENHLKWIARANGLSTKRVDEVLTLVGLTGVASKKTGGFSLGMGQRLGLAAALLGDPEYLILDEPVNGLDPEGIHWVRTLLQNIAKQGRTVLVSSHLLSEMAQTAEHLIVIGRGKLVADMPMHEFVRSHSASTVVVRAAVPGALENALKEAGVAFNTAPDESGRMTYRIDGSTTDDIGRLAFERGIALLELSETRASLEEAFLETTGEAVQYQAGSVDNND
>NC_006958.1|WP_011266001.1|2902560_2903055_-|NUDIX-hydrolase
MKGDGDGWAAAPNGGAVWGKNGAAGLLLVADKQMLMQHRAAWTNNGDTWALPGGARDSHETAAESALREAFEETGILPDDVEVLDSIVTAGPFPADPERPELAGNWTYTTVIARTKTGETLDTTANEESLELRWVDIAAVDSLALMPAFAKAWPSLRKLLNTTE
>NC_006958.1|WP_011266002.1|2903174_2904647_+|hypothetical-protein
MPNPLDDSAVQNSAPHSAPHSARTRLEFLDTDDSPDHWLDPLTEKDTSKRTLVNSIVQETFGQPIFVARKIWAFVNTSPGRMTLMTIIISIAIFAAGYAMSVSSDTRQSNLDDLITNAEPVSYNAHVLYTSLSVADTTATTGFVQAGVEGPVNRVKYHTAIDRAAVAATHTAASADSSNEHLMELVLEIQRQLPVYTGLVETARTNNRAGNPVGVAYMSEASAMMRNEILPMASELYNLTSRAVSDQQRSVTGPQWFPLSGLLAALAMLIVAQWWLMRITRRRINKGFALATVMMMTATLWVSAANWATWQAGTKGFEEASGPLNSMTTARIYAQQTRTTETLSLVRRQSIQGSGTGFTATINQIKRALDEYETTAQSQTPEHQQLITAIRNAIAAWTADHDEFTVLLASGDYNGAVNAVLNKDEEGQTSFDELDTALAELIADSRSSMRSYIQSGLQATELVSVMVMILSVVSVLALWVGIRPRLQEYL
>NC_006958.1|WP_011015348.1|2904647_2905682_+|glutamate-ABC-transporter-substrate-binding-protein
MHAFRRPPPLTTRVGAALLAATLLASCTPTPVEPAETLTALDPDAGPPLPPDSSIEAPGEKEPIVEVIENWPGSLRPDDLTPEERVPGIVNRGRIIVGVDQSQNLLSFRDPVTGELRGFEVELAREISRDIFGDPNKVDFRFVGSSDRLRSLDQGDVDIVIRSVTITDERAKLVEFSTPYLRTQTRMLTMESSGITSIADLPGHTICVTDGSTSLQRARTIAPEASILKTRNWSDCLMALQQHQAQVILGDDVILSGIAAQDPYTEILDTSLDSHSYGVAAASTTAETDSSGLIRQVNYTIERIRTDRMWWTMFDDWFGPYLWSYGPPQLQYMPEEEGTENDEG
>NC_006958.1|WP_011015349.1|2905671_2908140_+|serine/threonine-protein-kinase
MKDNEDFDPDSPATEAVAFNPFDDDDEDDSPATSAVAFNPFEDDDDDDEFQGEGLEFLLRDLDNLRATQGQMVVEQPAVEDSLGSASAHTETTAASLRPRPEVDPSERSRRQAISLFRERRRVRRQSRPVADGMVELPFITPKPEDELLIDPEKKRKPGVAAPQLVAGDIVAEQYEVLGVIAHGGMGWIYLANDRNVSGRIVVLKGMMAQSSVQDQGTAEAEREFLADITHPGIVKAYNFIDDPRVPGGFIVMEYVNGPSLKDRCKAQPDGVLRVDLAIGYILELLPAMDYLHQRGVVYNDLKPENVIATEDQVKLIDLGAVTGIGAFGYIYGTKGFQAPEVATHGPSISSDIFTIGRTLAALTMPLPVEDGVLAPGIPSPKNSPLLRRHLSFYRLLQRATADDPQHRFRNVSELRTQLYGVLREILAVRDGKQYPPQHSLFSPQRSTFGTKHLVFRTDRIIDGIERQARITAPEIVSALPVPLIDRTDPGARMLSGSSYAEPSETLETLRNSMEDEQYRQSIEIPLGVVRALLDLGFTTEARQWLETLEGRIGDDWRHKWFSGITYLLLDDYATAQVFFNHVLTILPGEAAPKLALAAVDELILQQIGAESTAYLTPDIVSATATLSKDFEDLDASAFESLSDTWSHISSDPHVVRFHSLRLYALVWATNPTTVSSAFGLARQLMAENQIELAVQALDKLPQSSTHYRMATLTTILLLVSSNLSESRIRRAARRLTEIPTNEPRFNQIKIAIMSAGLSWLRERKLKASASANPLFEYPFSQKGLRTGISEALRIQARSAPFPHHRYALVDMANAVRPLSWF
>NC_006958.1|WP_003862874.1|2908619_2909813_-|acetate-kinase
MALALVLNSGSSSIKFQLVNPENSAIDEPYVSGLVEQIGEPNGRIVLKIEGEKYTLETPIADHSEGLNLAFDLMDQHNCGPSQLEITAVGHRVVHGGILFSAPELITDEIVEMIRDLIPLAPLHNPANVDGIDVARKILPDVPHVAVFDTGFFHSLPPAAALYAINKDVAAEHGIRRYGFHGTSHEFVSKRVVEILEKPTEDINTITFHLGNGASMAAVQGGRAVDTSMGMTPLAGLVMGTRSGDIDPGIVFHLSRTAGMSIDEIDNLLNKKSGVKGLSGVNDFRELREMIDNNDQDAWSAYNIYIHQLRRYLGSYMVALGRVDTIVFTAGVGENAQFVREDALAGLEMYGIEIDPERNALPNDGPRLISTDASKVKVFVIPTNEELAIARYAVKFA

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_006958_2	2.3\|2066401\|27\|NC_006958\|CRISPRCasFinder	2066401-2066427	27	MF668280	Mycobacterium phage Phabba, complete genome	18926-18952	5	0.815
NC_006958_2	2.1\|2066272\|33\|NC_006958\|CRISPRCasFinder	2066272-2066304	33	MT330372	Cronobacter phage JC01, complete genome	60750-60782	7	0.788

1. spacer 2.3|2066401|27|NC_006958|CRISPRCasFinder matches to MF668280 (Mycobacterium phage Phabba, complete genome) position: , mismatch: 5, identity: 0.815

cggctgctgcaggctttgcctgaacgc	CRISPR spacer
ctcgtactgcaggctttgcatgaacgc	Protospacer
*   *.************* *******

2. spacer 2.1|2066272|33|NC_006958|CRISPRCasFinder matches to MT330372 (Cronobacter phage JC01, complete genome) position: , mismatch: 7, identity: 0.788

tagctgcatcgcctggagttgggccagaaaatg	CRISPR spacer
cgcccgcatcgcctggagccgggccagaaaatc	Protospacer
.. *.*************..************

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage