CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_014251	Streptococcus pneumoniae TCH8431/19A, complete sequence	3 crisprs	DEDDh,cas3,DinG	0	1	14	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_014251_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014251_1

1279965-1280068

Orphan

Consensus_repeat	Method
CTCTATAATATTTGTAGTGGGTAAATCCACTAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014251_1

>merge|NC_014251|1|1279965-1280068|CRISPRCasFinder
CTCTATAATATTTGTAGTGGGTAAATCCACTATAGATATTATGGAGCCTATTTTATTGTAGAAAAAAAGGGCTCTATAATATTTGTAGTGGGTAAATCCCCTAT

>NC_014251|1|1|1279965-1280068|CRISPRCasFinder
CTCTATAATATTTGTAGTGGGTAAATCCACTAT	AGATATTATGGAGCCTATTTTATTGTAGAAAAAAAGGG
CTCTATAATATTTGTAGTGGGTAAATCCCCTAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_014251.1\|WP_001284639.1\|1273264_1273540_-\|HU-family-DNA-binding-protein	unknown	unknown	gnl\|CDD\|259853
NC_014251.1\|WP_000451584.1\|1281797_1282772_-\|phosphate-acetyltransferase	unknown	unknown	gnl\|CDD\|236609
NC_014251.1\|WP_001283813.1\|1285991_1286951_+\|ribose-phosphate-diphosphokinase	unknown	unknown	gnl\|CDD\|235039
NC_014251.1\|WP_000592056.1\|1274627_1275476_+\|YitT-family-protein	unknown	unknown	gnl\|CDD\|224203
NC_014251.1\|WP_000109141.1\|1278003_1278318_-\|50S-ribosomal-protein-L21	unknown	unknown	gnl\|CDD\|235510
NC_014251.1\|WP_000161392.1\|1273646_1274486_-\|DegV-family-protein	unknown	unknown	gnl\|CDD\|273257
NC_014251.1\|WP_000613700.1\|1277643_1277988_-\|ribosomal-processing-cysteine-protease-Prp	unknown	unknown	gnl\|CDD\|225423
NC_014251.1\|WP_000584888.1\|1270936_1272838_-\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NC_014251.1\|WP_000916509.1\|1277333_1277627_-\|50S-ribosomal-protein-L27	unknown	unknown	gnl\|CDD\|235464
NC_014251.1\|WP_000509041.1\|1278505_1279204_-\|DUF1275-domain-containing-protein	unknown	unknown	gnl\|CDD\|226146
NC_014251.1\|WP_000171676.1\|1284510_1285182_-\|GTP-pyrophosphokinase-family-protein	unknown	unknown	gnl\|CDD\|225232
NC_014251.1\|WP_000681293.1\|1285309_1285879_+\|CYTH-domain-containing-protein	unknown	unknown	gnl\|CDD\|226601
NC_014251.1\|WP_000981526.1\|1279605_1279905_+\|YbaB/EbfC-family-nucleoid-associated-protein	unknown	unknown	gnl\|CDD\|234669
NC_014251.1\|WP_000799053.1\|1283708_1284527_-\|NAD-kinase	unknown	unknown	gnl\|CDD\|235317
NC_014251.1\|WP_000462487.1\|1288435_1288651_+\|DUF4649-family-protein	unknown	unknown	gnl\|CDD\|339492
NC_014251.1\|WP_000653403.1\|1288733_1289375_+\|redox-sensing-transcriptional-repressor-Rex	unknown	unknown	gnl\|CDD\|225221
NC_014251.1\|WP_001210006.1\|1282815_1283712_-\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638
NC_014251.1\|WP_000639664.1\|1286960_1288076_+\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|224029
NC_014251.1\|WP_000587444.1\|1275568_1276486_-\|bifunctional-riboflavin-kinase/FAD-synthetase	unknown	unknown	gnl\|CDD\|235536
NC_014251.1\|WP_000863509.1\|1288080_1288428_+\|DUF1831-domain-containing-protein	unknown	unknown	gnl\|CDD\|370163

Protein	Function_ID	Function_description	E-value
NC_014251.1\|WP_001284639.1\|1273264_1273540_-\|HU-family-DNA-binding-protein	gnl\|CDD\|259853	cd13831, HU, histone-like DNA-binding protein HU. This subfamily includes HU and HU-like domains. HU is a conserved nucleoid-associated protein (NAP) which binds non-specifically to duplex DNA with a particular preference for targeting nicked and bent DNA. It is highly basic and contributes to chromosomal compaction and maintenance of negative supercoiling, thus often referred to as histone-like protein. HU can induce DNA bends, condense DNA in a fiber and also interact with single stranded DNA. It contains two homologous subunits, alpha and beta, typically forming homodimers (alpha-alpha and beta-beta), except in E. coli and other enterobacteria, which form heterodimers (alpha-beta). In E. coli, HU binds uniformly to the chromosome, with a preference for damaged or distorted DNA structures and can introduce negative supercoils into closed circular DNA in the presence of topoisomerase I. Anabaena HU (AHU) shows preference for A/T-rich region in the center of its DNA binding site.	4.4762e-40
NC_014251.1\|WP_000451584.1\|1281797_1282772_-\|phosphate-acetyltransferase	gnl\|CDD\|236609	PRK09653, eutD, phosphotransacetylase.	0
NC_014251.1\|WP_001283813.1\|1285991_1286951_+\|ribose-phosphate-diphosphokinase	gnl\|CDD\|235039	PRK02458, PRK02458, ribose-phosphate pyrophosphokinase; Provisional.	0
NC_014251.1\|WP_000592056.1\|1274627_1275476_+\|YitT-family-protein	gnl\|CDD\|224203	COG1284, COG1284, Uncharacterized conserved protein [Function unknown].	4.30505e-85
NC_014251.1\|WP_000109141.1\|1278003_1278318_-\|50S-ribosomal-protein-L21	gnl\|CDD\|235510	PRK05573, rplU, 50S ribosomal protein L21; Validated.	6.1021e-45
NC_014251.1\|WP_000161392.1\|1273646_1274486_-\|DegV-family-protein	gnl\|CDD\|273257	TIGR00762, DegV, EDD domain protein, DegV family. This family of proteins is related to DegV of Bacillus subtilis and includes paralogous sets in several species (B. subtilis, Deinococcus radiodurans, Mycoplasma pneumoniae) that are closer in percent identity to each than to most homologs from other species. This suggests both recent paralogy and diversity of function. DegV itself is encoded immediately downstream of DegU, a transcriptional regulator of degradation, but is itself uncharacterized. Crystallography suggested a lipid-binding site, while comparison of the crystal structure to dihydroxyacetone kinase and to a mannose transporter EIIA domain suggests a conserved domain, EDD, with phosphotransferase activity. [Unknown function, General].	3.43566e-110
NC_014251.1\|WP_000613700.1\|1277643_1277988_-\|ribosomal-processing-cysteine-protease-Prp	gnl\|CDD\|225423	COG2868, COG2868, Predicted ribosomal protein [Translation, ribosomal structure and biogenesis].	4.93617e-39
NC_014251.1\|WP_000584888.1\|1270936_1272838_-\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	0
NC_014251.1\|WP_000916509.1\|1277333_1277627_-\|50S-ribosomal-protein-L27	gnl\|CDD\|235464	PRK05435, rpmA, 50S ribosomal protein L27; Validated.	6.08512e-51
NC_014251.1\|WP_000509041.1\|1278505_1279204_-\|DUF1275-domain-containing-protein	gnl\|CDD\|226146	COG3619, COG3619, Predicted membrane protein [Function unknown].	8.49808e-63
NC_014251.1\|WP_000171676.1\|1284510_1285182_-\|GTP-pyrophosphokinase-family-protein	gnl\|CDD\|225232	COG2357, COG2357, PpGpp synthetase catalytic domain [General function prediction only].	7.7772e-102
NC_014251.1\|WP_000681293.1\|1285309_1285879_+\|CYTH-domain-containing-protein	gnl\|CDD\|226601	COG4116, COG4116, Uncharacterized protein conserved in bacteria [Function unknown].	1.98141e-96
NC_014251.1\|WP_000981526.1\|1279605_1279905_+\|YbaB/EbfC-family-nucleoid-associated-protein	gnl\|CDD\|234669	PRK00153, PRK00153, YbaB/EbfC family nucleoid-associated protein.	1.2452e-33
NC_014251.1\|WP_000799053.1\|1283708_1284527_-\|NAD-kinase	gnl\|CDD\|235317	PRK04885, ppnK, inorganic polyphosphate/ATP-NAD kinase; Provisional.	9.83191e-171
NC_014251.1\|WP_000462487.1\|1288435_1288651_+\|DUF4649-family-protein	gnl\|CDD\|339492	pfam15507, DUF4649, Domain of unknown function (DUF4649). This family of Firmicute sequences has members that are annotated as ribose-phosphate pyrophosphokinase; however there is no evidence for this attribution. Member proteins are all shorter than 100 residues in length.	1.64583e-27
NC_014251.1\|WP_000653403.1\|1288733_1289375_+\|redox-sensing-transcriptional-repressor-Rex	gnl\|CDD\|225221	COG2344, COG2344, AT-rich DNA-binding protein [General function prediction only].	1.79308e-117
NC_014251.1\|WP_001210006.1\|1282815_1283712_-\|RluA-family-pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	8.56983e-100
NC_014251.1\|WP_000639664.1\|1286960_1288076_+\|cysteine-desulfurase	gnl\|CDD\|224029	COG1104, NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism].	4.06104e-174
NC_014251.1\|WP_000587444.1\|1275568_1276486_-\|bifunctional-riboflavin-kinase/FAD-synthetase	gnl\|CDD\|235536	PRK05627, PRK05627, bifunctional riboflavin kinase/FAD synthetase.	8.98101e-130
NC_014251.1\|WP_000863509.1\|1288080_1288428_+\|DUF1831-domain-containing-protein	gnl\|CDD\|370163	pfam08866, DUF1831, Putative amino acid metabolism. Solution of the structure of the Lactobacillus plantarum protein from this family has indicated a potential new fold with remote similarities to TBP-like (TATA-binding protein) structures. This similarity, in combination with genomic context analysis, leads us to propose an involvement in amino-acid metabolism. The potentially novel fold is an alpha + beta fold comprising two beta sheets packed against a single helix. The enzyme is present in the cytosol.	7.32693e-51

>NC_014251.1|WP_000981526.1|1279605_1279905_+|YbaB/EbfC-family-nucleoid-associated-protein
MMNMQNMMRQAQKLQKQMEQSQAELAAMQFVGKSAQDLVQATLTGDKKVVSIDFNPAVVDPEDLETLSDMTVQAINSALEQIDETTKKKLGAFAGKLPF
>NC_014251.1|WP_000509041.1|1278505_1279204_-|DUF1275-domain-containing-protein
MGGKMRLLPIRKISRQSKRLALFLTFCAGYVDAYTFIVRGNTLVAGQTGNVVFLSVELIKNNVSDVRDKVLTLLAFMMGVFLLTIYKEKLRIVKKPILSLIPLAILSIIIAFVPQTVDNIYLVPPLAFCMGLVTTAFGEVSGIAYNNAFMTGNIKRTMLAFGDYFRTKHTPFLREGFIFVSLLSSFVLGVVFSAYLTIFYHEKTILGVPIMMSVFYLSMLFASWQKKVKEKA
>NC_014251.1|WP_000109141.1|1278003_1278318_-|50S-ribosomal-protein-L21
MSTYAIIKTGGKQVKVEVGQAVYVEKLNVEAGQEVTFNEVVLVGGENTVVGTPLVAGATVVGTVEKQGKQKKVVTYKYKPKKGSHRKQGHRQPYTKVVINAINA
>NC_014251.1|WP_000613700.1|1277643_1277988_-|ribosomal-processing-cysteine-protease-Prp
MIQAVFERAEDGELRSAEITGHAESGEYGLDVVCASVSTLAINFINSIEKFAGYEPILELNEDEGGYLMVEIPKDLPSHQREMTQLFFESFFLGMANLSENYSEFVQTRVITEN
>NC_014251.1|WP_000916509.1|1277333_1277627_-|50S-ribosomal-protein-L27
MLKMTLNNLQLFAHKKGGGSTSNGRDSQAKRLGAKAADGQTVTGGSILYRQRGTHIYPGVNVGRGGDDTLFAKVEGVVRFERKGRDKKQVSVYPIAK
>NC_014251.1|WP_000587444.1|1275568_1276486_-|bifunctional-riboflavin-kinase/FAD-synthetase
MIITIPIKNQKDIGTPSDSVVVLGYFDGIHKGHQELFRVANKAARKDLLPIVVMTFNESPKIALEPYHPDLFLHILNPAERERKLKREGVEELYLLDFSSQFASLTAQEFFATYIKAMNAKIIVAGFDYTFGSDKKTAEDLKDYFDGEVIIVPPVEDEKGKISSTRIRQAILDGNVKEAGKLLGAPLPSRGMVVHGNARGRTIGYPTANLVLLDRTYMPADGVYVVDVEIQRQKYRAMASVGKNVTFDGEEARFEVNIFDFNQDIYGETVMVYWLDRIRDMTKFDSVDQLVDQLKADEEVTRNWS
>NC_014251.1|WP_000592056.1|1274627_1275476_+|YitT-family-protein
MIKKIYPIFTILLGAAIYAFGLTYFVVPHHLFEGGATGITLITFYLFKIPVSLMNLLINIPLFILAWKIFGAKSLYSSLLGTLALSAWLAFFEHIPLHIDLQGDLLITALIAGILLGIGLGIIFNAGGTTGGTDILARILNKYTHISIGKLLFILDFCILMLILLIFKDLRLVSYTLLFDFIVSRVIDLIGEGGYAGKGFMIITKRPDQLAKAINDDLGRGVTFISGQGYYSKENLKIIYCIVGRNEIVKTKEMIHRIDPQAFITITEAHEILGEGFTFEKE
>NC_014251.1|WP_000161392.1|1273646_1274486_-|DegV-family-protein
MTKIKIVTDSSVTIEPELVKQLDITIVPLSVMIDNVVYSDADLKEEGKFLQLMQESKNLPKTSQPPVGVFAEIFEDLCKDGGQILAIHMSHALSGTVEAARQGASLSTADVTVVDSSFTDQALKFQVVEAAKLAQEGKDMEAILCHVEEVKNHTELYIGVSTLENLVKGGRISRVTGLLSSLLNIRVVMQMKDHELQPMVKGRGTKTFKKWLDELITSLSERAVAEIGISYSGSDDWAKEMKESLQAYVEKPISVLETGSIIQTHTGENAWAILIRYHS
>NC_014251.1|WP_001284639.1|1273264_1273540_-|HU-family-DNA-binding-protein
MANKQDLIAKVAEATELTKKDSAAAVEAVFAAVADYLAAGEKVQLIGFGNFEVRERAERKGRNPQTGKEMTIAASKVPAFKAGKALKDAVK
>NC_014251.1|WP_000584888.1|1270936_1272838_-|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MIILQANKIERSFAGEVLFDNINLQVDERDRIALVGKNGAGKSTLLKILVGEEEPTSGEINKKKDISLSYLAQDSRFESENTIYDEMLHVFNNLRRTERQLRQMELEMGEKSGEDLDKLMSDYDRLSENFRQAGGFTYEADIRAILNGFKFDESMWQMKIAELSGGQNTRLALAKMLLEKPNLLVLDEPTNHLDIETIAWLENYLVNYSGALLIVSHDRYFLDKVATITLDLTKHSLDRYVGNYSRFVELKEQKLATEAKNYEKQQKEIAALEDFVNRNLVRASTTKRAQSRRKQLEKMERLDKPEAGKKAANMTFQSEKTSGNVVLTVENTAIGYDGEVLSQPINLDLRKMNAVAIVGPNGIGKSTFIKSIVDQIPFIKGEKRFGANVEVGYYDQTQSKLTPSNTVLDELWNDFKLTPEVEIRNRLGAFLFSGDDVKKSVGMLSGGEKARLLLAKLSMENNNFLILDEPTNHLDIDSKEVLENALIDFDGTLLFVSHDRYFINRVATHVLELSENGSTLYLGDYDYYVEKKATAEMSQTEEASTSNQAKEASPVNDYQAQKESQKEVRKLMRQIESLEAEIEELESQSQAISEQMLETNDADKLMELQAELDKISHRQEEAMLEWEELSDQV
>NC_014251.1|WP_000451584.1|1281797_1282772_-|phosphate-acetyltransferase
MEVFESLKANLVGKNARIVLPEGEEPRILQATKRLVKETEVIPVLLGNPEKIKIYLEIEGIMDGYEVIDPQHYPQFEEMVSALVERRKGKMTEEDVRKVLVEDVNYFGVMLVYLGLVDGMVSGAIHSTASTVRPALQIIKTRPNVTRTSGAFLMVRGTERYLFGDCAININPDAEALAEIAINSAITAKMFGIEPKIAMLSYSTKGSGFGESVDKVVEATKIAHDLRPDLEIDGELQFDAAFVPETAALKAPGSTVAGQANVFIFPGIEAGNIGYKMAERLGGFAAVGPVLQGLNKPVNDLSRGCNADDVYKLTLITAAQAVHQ
>NC_014251.1|WP_001210006.1|1282815_1283712_-|RluA-family-pseudouridine-synthase
MRFEFIADEHVKVKTFLKKHEVSKGLLAKIKFRGGAILVNNQPQNATYLLDVGDYVTIDIPAEKGFETLEAIELPLDILYEDDHFLVLNKPYGVASIPSVNHSNTIANFIKGYYVKQNYENQQVHIVTRLDRDTSGLMLFAKHGYAHARLDKQLQKKSIEKRYFALVKGDGHLEPEGEIIAPIARDEDSIITRRVAKGGKYAHTSYKIVASYGNIHLVDIRLHTGRTHQIRVHFSHIGFPLLGDDLYGGSLDDGIQRQALHCHYLSFYHPFLEQDLQLESPLPDDFSNLITQLSTNTL
>NC_014251.1|WP_000799053.1|1283708_1284527_-|NAD-kinase
MKNTGKRIDLIANRKPQSQRVLYELRDRLKRNQFILNDTNPDIVISIGGDGMLLSAFHKYENQLDKVRFIGLHTGHLGFYTDYRDFELDKLVTNLQLDTGARVSYPVLNVKVFLENGEVKIFRALNEASIRRSDRTMVADIVINGVPFERFRGDGLTVSTPTGSTAYNKSLGGAVLHPTIEALQLTEIASLNNRVYRTLGSSIIVPKKDKIELIPTRNDYHTISVDNSVYSFRNIERIEYQIDHHKIHFVATPSHTSFWNRVKDAFIGEVDE
>NC_014251.1|WP_000171676.1|1284510_1285182_-|GTP-pyrophosphokinase-family-protein
MTLEWEEFLDPYIQAVGELKIKLRGIRKQYRKQNKHSPIEFVTGRVKPIESIKEKMARRGITYATLEHDLQDIAGLRVMVQFVDDVKEVVDILHKRQDMRIIQERDYITHRKASGYRSYHVVVEYTVDTINGAKTILAEIQIRTLAMNFWATIEHSLNYKYQGDFPDEIKKRLEITARIAHQLDEEMGEIRDDIQEAQALFDPLSRKLNDGVGNSDDTDEEYR
>NC_014251.1|WP_000681293.1|1285309_1285879_+|CYTH-domain-containing-protein
MKHLEIELKTLLKKDEYNRLKDQFTGVTPVLQTNYYIDTPDFELREKKVAMRIRTFEDWAELTLKVPQSVGNMEYNQKLQLKDAENYLSKEELPQGLVLDELAKHGIQSKNWQVLGCLTTLRYEMKTAIGLMALDQSRYFDMTDYELELEVENHEQGKQDFRQFLEKNQISYQKAPSKLVRFVKSMKNS
>NC_014251.1|WP_001283813.1|1285991_1286951_+|ribose-phosphate-diphosphokinase
MSDRKNMKLFALNSNQEIAQKIAQAVGVPLGKLSSRQFSDGEIQVNIEESVRGYDVYIIQSTSFPVNNHLMELLIMVDACVRASAHSINVVLPYFGYARQDRIACPREPLTAKLVANMLVKAGVDRILTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYCDKGLLGSDVVVVSPKNSGVKRARSLAEYLDAPIAIIDYPQDDATRNEGYIIGDVEGKKAILIDDILNTGRTFSEASKIVEREGATEIYAVSSHGLFVEGAAELLDNTNIKEILVTDSVATKEKTPKNVCYITASELIGDAIVRIHERKPVSPLFAYNKKK
>NC_014251.1|WP_000639664.1|1286960_1288076_+|cysteine-desulfurase
MIYLDNAATTPMSAVAISAMTKVMQETHGNPSSIHGHGRQAGKLLREARQELAQLLRTKPQHIFFTSGGTEGNNTTIIGYCLRHQEQGKHIITTAIEHHAVLETIDYLVQHFGFEATIIQPENQEITAQQIQKALRDDTILVSTMFANNETGNLLPIAEIGQILKQHPAAYHVDAVQAIGKIPIHSEELGIDFLTASAHKFHGPKGIGFLYASSMDFDSYLHGGDQEQKKRAGTENLPAIVGMVAALKEDLEKQEEHFQHVQNLETAFLAELEGIQYYLNRGKHHLPYVLNIGFPGQKNDLLLLRLDLAGISISTGSACTAGVVQSSHVLKAMYGANSERLKESLRISLSPQNTVEDLQTLAKTLKEIIGG
>NC_014251.1|WP_000863509.1|1288080_1288428_+|DUF1831-domain-containing-protein
MAFEKIIQLKNCRYDYTLSPSVKKFTLKDNTFFETKVGNYELTRLLEKVPNSGEGFQLKIIINKELTGAKINITDKFGLRLVDIFKSEDHHIHQEKFYFLMDSLVERGVFTKSER
>NC_014251.1|WP_000462487.1|1288435_1288651_+|DUF4649-family-protein
MFELTYKDCYHVERTLKYEDHEALMLTLSGCVTLPDTLYVTSLTFRGKKVYQGLVGDLYRFLSHADFLHQN
>NC_014251.1|WP_000653403.1|1288733_1289375_+|redox-sensing-transcriptional-repressor-Rex
MKDKQFAIPKATAKRLSLYYRIFKRFHAEKIERANSKQIAEAIGIDSATVRRDFSYFGELGRRGFGYDVKKLMTFFADLLNDNSITNVMLVGIGNMGHALLHYRFHERNKMKIIMAFDLDDHPEVGTQTPDGIPIYGISQIKDKIKDADVKTAILTVPSVKSQEVANLLVDAGVKGILSFSPVHLHLPKDVVVQYVDLTSELQTLLYFMRKED

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Crispr_ID: NC_014251_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014251_2

1632601-1632733

Orphan

Consensus_repeat	Method
ACTTCTGGTGTCGGTACATTTGGTG	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_014251_2

>merge|NC_014251|2|1632601-1632733|CRISPRCasFinder
TGTTCTGGAACCGGTACTTCTGGTGTTGGAACAGCTGGAGTTGGTTGTACTGGCACTTCTGGTGTCGGTACATTTGGTGTTGGTTGCGCTGGCACAGGTTTAACCAGTACTTCTGGTGTCGGCACATTTGGTG

>NC_014251|2|2|1632601-1632733|CRISPRCasFinder
TGTTCTGGAACCGGTACTTCTGGTG	TTGGAACAGCTGGAGTTGGTTGTACTGGC
ACTTCTGGTGTCGGTACATTTGGTG	TTGGTTGCGCTGGCACAGGTTTAACCAGT
ACTTCTGGTGTCGGCACATTTGGTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_014251.1\|WP_000032458.1\|1643759_1646456_-\|cation-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319781
NC_014251.1\|WP_001245190.1\|1638250_1639735_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|285470
NC_014251.1\|WP_000777792.1\|1629635_1630823_-\|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl\|CDD\|235596
NC_014251.1\|WP_000822863.1\|1640822_1642418_-\|hypothetical-protein	unknown	unknown	unknown
NC_014251.1\|WP_000068664.1\|1626719_1626959_-\|30S-ribosomal-protein-S18	unknown	unknown	gnl\|CDD\|178997
NC_014251.1\|WP_000689600.1\|1624663_1625023_-\|S1-RNA-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|180908
NC_014251.1\|WP_000813916.1\|1646759_1647944_+\|CDF-family-manganese-efflux-transporter-MntE	unknown	unknown	gnl\|CDD\|223131
NC_014251.1\|WP_000339034.1\|1625024_1626425_-\|bifunctional-Cof-type-HAD-IIB-family-hydrolase/peptidylprolyl-isomerase	unknown	unknown	gnl\|CDD\|223725
NC_014251.1\|WP_000412220.1\|1642429_1642840_-\|peptide-deformylase	unknown	unknown	gnl\|CDD\|181704
NC_014251.1\|WP_001138814.1\|1649954_1651139_-\|CCA-tRNA-nucleotidyltransferase	unknown	unknown	gnl\|CDD\|237339
NC_014251.1\|WP_001279133.1\|1648086_1649958_-\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NC_014251.1\|WP_000697775.1\|1639785_1640514_-\|peroxide-stress-protein-YaaA	unknown	unknown	gnl\|CDD\|234999
NC_014251.1\|WP_000508269.1\|1640592_1640757_-\|YczI-family-protein	unknown	unknown	gnl\|CDD\|315732
NC_014251.1\|WP_001277403.1\|1642955_1643747_-\|glutathione-dependent-disulfide-bond-oxidoreductase	unknown	unknown	gnl\|CDD\|183298
NC_014251.1\|WP_000039614.1\|1631628_1632177_+\|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223508
NC_014251.1\|WP_000609607.1\|1626990_1627461_-\|single-stranded-DNA-binding-protein-SsbA	unknown	unknown	gnl\|CDD\|180915
NC_014251.1\|WP_000747253.1\|1630819_1631308_-\|DUF5590-domain-containing-protein	unknown	unknown	gnl\|CDD\|227656
NC_014251.1\|WP_001151785.1\|1627472_1627763_-\|30S-ribosomal-protein-S6	unknown	unknown	gnl\|CDD\|179034
NC_014251.1\|WP_161801414.1\|1627915_1629262_-\|asparagine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235176
NC_014251.1\|WP_000565216.1\|1629418_1629643_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|319923

Protein	Function_ID	Function_description	E-value
NC_014251.1\|WP_000032458.1\|1643759_1646456_-\|cation-translocating-P-type-ATPase	gnl\|CDD\|319781	cd02089, P-type_ATPase_Ca_prok, prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL and Listeria monocytogenes LMCA1. Ca(2+) transport ATPase is a plasma membrane protein which pumps Ca(2+) ion out of the cytoplasm. This prokaryotic subfamily includes the Ca(2+)-ATPase Synechococcus elongatus PacL, Listeria monocytogenes Ca(2+)-ATPase 1 (LMCA1) which has a low Ca(2+) affinity and a high pH optimum (pH about 9) and may remove Ca(2+) from the microorganism in environmental conditions when e.g. stressed by high Ca(2+) and alkaline pH, and the Bacillus subtilis putative P-type Ca(2+)-transport ATPase encoded by the yloB gene, which is expressed during sporulation. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NC_014251.1\|WP_001245190.1\|1638250_1639735_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|285470	pfam08270, PRD_Mga, M protein trans-acting positive regulator (MGA) PRD domain. Mga is a DNA-binding protein that activates the expression of several important virulence genes in group A streptococcus in response to changing environmental conditions. This corresponds to the PRD like region.	2.08116e-76
NC_014251.1\|WP_000777792.1\|1629635_1630823_-\|pyridoxal-phosphate-dependent-aminotransferase	gnl\|CDD\|235596	PRK05764, PRK05764, aspartate aminotransferase; Provisional.	0
NC_014251.1\|WP_001279133.1\|1648086_1649958_-\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	0
NC_014251.1\|WP_000068664.1\|1626719_1626959_-\|30S-ribosomal-protein-S18	gnl\|CDD\|178997	PRK00391, rpsR, 30S ribosomal protein S18; Reviewed.	3.32721e-37
NC_014251.1\|WP_000689600.1\|1624663_1625023_-\|S1-RNA-binding-domain-containing-protein	gnl\|CDD\|180908	PRK07252, PRK07252, S1 RNA-binding domain-containing protein.	1.98721e-79
NC_014251.1\|WP_000813916.1\|1646759_1647944_+\|CDF-family-manganese-efflux-transporter-MntE	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	3.68565e-101
NC_014251.1\|WP_000339034.1\|1625024_1626425_-\|bifunctional-Cof-type-HAD-IIB-family-hydrolase/peptidylprolyl-isomerase	gnl\|CDD\|223725	COG0652, PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones].	5.47265e-62
NC_014251.1\|WP_000412220.1\|1642429_1642840_-\|peptide-deformylase	gnl\|CDD\|181704	PRK09218, PRK09218, peptide deformylase; Validated.	5.2801e-91
NC_014251.1\|WP_001138814.1\|1649954_1651139_-\|CCA-tRNA-nucleotidyltransferase	gnl\|CDD\|237339	PRK13299, PRK13299, tRNA CCA-pyrophosphorylase; Provisional.	0
NC_014251.1\|WP_000697775.1\|1639785_1640514_-\|peroxide-stress-protein-YaaA	gnl\|CDD\|234999	PRK02101, PRK02101, peroxide stress protein YaaA.	5.15942e-96
NC_014251.1\|WP_000508269.1\|1640592_1640757_-\|YczI-family-protein	gnl\|CDD\|315732	pfam13129, DUF3953, Protein of unknown function (DUF3953). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 47 and 76 amino acids in length.	0.000993842
NC_014251.1\|WP_001277403.1\|1642955_1643747_-\|glutathione-dependent-disulfide-bond-oxidoreductase	gnl\|CDD\|183298	PRK11752, PRK11752, putative S-transferase; Provisional.	0
NC_014251.1\|WP_000039614.1\|1631628_1632177_+\|NAD(P)H-dependent-oxidoreductase	gnl\|CDD\|223508	COG0431, COG0431, Predicted flavoprotein [General function prediction only].	1.09403e-32
NC_014251.1\|WP_000609607.1\|1626990_1627461_-\|single-stranded-DNA-binding-protein-SsbA	gnl\|CDD\|180915	PRK07275, PRK07275, single-stranded DNA-binding protein; Provisional.	1.66017e-101
NC_014251.1\|WP_000747253.1\|1630819_1631308_-\|DUF5590-domain-containing-protein	gnl\|CDD\|227656	COG5353, COG5353, Uncharacterized protein conserved in bacteria [Function unknown].	3.22216e-58
NC_014251.1\|WP_001151785.1\|1627472_1627763_-\|30S-ribosomal-protein-S6	gnl\|CDD\|179034	PRK00453, rpsF, 30S ribosomal protein S6; Reviewed.	1.40041e-37
NC_014251.1\|WP_161801414.1\|1627915_1629262_-\|asparagine--tRNA-ligase	gnl\|CDD\|235176	PRK03932, asnC, asparaginyl-tRNA synthetase; Validated.	0
NC_014251.1\|WP_000565216.1\|1629418_1629643_-\|hypothetical-protein	gnl\|CDD\|319923	cd07262, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	1.22811e-09

>NC_014251.1|WP_000039614.1|1631628_1632177_+|NAD(P)H-dependent-oxidoreductase
MSKKVLFIVGSLRQGSFNHQMALEAEKALAGKAEVSYLDYSALPLFSQDLEVPTHPAVAAAREAVLVADAIWIFSPVYNFSIPGTVKNLLDWLSRALDLSDTRGASALQDKFVTVSSVANAGHDQLFAIYKDLLPFIRTQGVGDFTAARVNDSAWADGKLVLEETVLNSLEKQAQDLVEAIQ
>NC_014251.1|WP_000747253.1|1630819_1631308_-|DUF5590-domain-containing-protein
MKKRQNKAKNNLLWQYGLGMTILFVVISASFLYMVSLSMKPYQTAKSEGEKLAQQYAGLEQADQVDLYNGLESYYSVLGRNKQQEALAVLIGKDDHKIYVYQLNQGVSQEKAETVSKEKGAGEIDKIIFGRYQDKPIWEVKSGSDFYLVDFETGALVNKEGL
>NC_014251.1|WP_000777792.1|1629635_1630823_-|pyridoxal-phosphate-dependent-aminotransferase
MKLSNRVLEMEESVTLAAGARAKALKAEGRDILSLTLGEPDFTTPKNIQDAAIASIRDGRASFYTVTSGLPELKAVVNSYFERFYGYSVASNQVTVAAGAKYSLYTFFMAVVNPGDEVIIPTPYWVSYGDQVKMAEGVPVFVSAKEDNHFKVTVEQLEVARTDKTKVLVLNSPSNPTGMIYTREELLAIGNWAVENDILILADDIYGRLVYNGHEFTPISSLSEAIRKQTVVINGVSKTYAMTGWRIGYAVGEADIIAAMSKIAGQTTSNPSAVAQYAAVEALSGEQDTVESMRQAFEERLNTIYPLLAEVPGFEVVKPQGAFYLFPNVKKAMEMKGYTDVTDFTTAILEESEVALVTGAGFGAPENVRLSYATDLDTLKEAVERLKAFMGSEND
>NC_014251.1|WP_000565216.1|1629418_1629643_-|hypothetical-protein
MIDHFEIKVKDLQISEGFYRSFLAPLDYKLAFKTSSLISFLSPNSPHPGGDFWLTQGTQDPVHFAFLAENKEEV
>NC_014251.1|WP_161801414.1|1627915_1629262_-|asparagine--tRNA-ligase
MMTKRVTIIDVKDYVGQEVTIGAWVANKSGKGKIAFLQLRDGTAFFQGVAFKPNFVEKFGEEVGLEKFDVIKRLSQETSVYVTGIVKEDERSKFGYELDITDIEVIGESQDYPITPKEHGTDFLMDNRHLWLRSRKQVAVLQIRNAIIYATYEFFDKNGFMKFDSPILSGNAAEDSTELFETDYFGTPAYLSQSGQLYLEAGAMALGRVFDFGPVFRAEKSKTRRHLTEFWMMDAEYSYLTHDESLDLQEAYVKALLQGVLDRAPQALETLERDTELLKRYIAEPFKRITYDQAIDLLQEHENDEDADYEHLEHGDDFGSPHETWISNHFGVPTFVMNYPAAIKAFYMKPVPGNPERVLCADLLAPEGYGEIIGGSMREEDYDALVAKMDELGMDRTEYEFYLDLRKYGTVPHGGFGIGIERMVTFAAGTKHIREAIPFPRMLHRIKP
>NC_014251.1|WP_001151785.1|1627472_1627763_-|30S-ribosomal-protein-S6
MAKYEILYIIRPNIEEEAKNALVARFDSILTDNGATVVESKTWEKRRLAYEIQDFREGLYHIVNVEANDDAALKEFDRLSKINADILRHMIVKIDA
>NC_014251.1|WP_000609607.1|1626990_1627461_-|single-stranded-DNA-binding-protein-SsbA
MINNVVLVGRMTRDAELRYTPSNVAVATFTLAVNRTFKSQNGEREADFINVVMWRQQAENLANWAKKGSLIGVTGRIQTRSYDNQQGQRVYVTEVVAENFQMLESRSVREGHTGGAYSAPTANYSAPTNSVPDFSRNENPFGATNPLDISDDDLPF
>NC_014251.1|WP_000068664.1|1626719_1626959_-|30S-ribosomal-protein-S18
MAQQRRGGFKRRKKVDYIAANKIEYVDYKDTELLSRFVSERGKILPRRVTGTSAKNQRKVTTAIKRARVMALMPFVNED
>NC_014251.1|WP_000339034.1|1625024_1626425_-|bifunctional-Cof-type-HAD-IIB-family-hydrolase/peptidylprolyl-isomerase
MDAKLRYKAKKIKIVFFDIDDTLRNSKTGFIPTTIPTVFKQLREKGILTGIASGRGIFGVVPEIRDLKPDFFVTLNGAYIEDKKGQVIYQHQIGKSDVEEYISWAKQEGIEYGLVGSHDAKLSTRTDMMSEAINPIYPDLDVDPDFHEKEDIYQMWTFEDKGDDLHLPDSLSDKLRMVRWHQHSSDIVPISGSKATGVEKVVEHLGLKPEKVMVFGDGLNDLELFDYAGISVAMGISHDKIKEKADYITKTLEEDGIFDALEVFGMVEKELHFPQVDIETVEGPLATIKTNHGDLRIKLFPEHAPKTVANFVSLSKDGYYDGVIFHRIIKDFMIQGGDPTGTGMGGESIYGESFEDEFSEELYNIRGALSMANAGPNTNGSQFFIVQNQHLPYSKKEITRGGWPEPIAEIYANQGGTPHLDRRHTVFGQLADEASYAVLDAIAAVETGAMDKPVEDVVIETIEIED
>NC_014251.1|WP_000689600.1|1624663_1625023_-|S1-RNA-binding-domain-containing-protein
MKIGDKLKGRITGIQPYGAFVELETGDTGLIHISEIRTGFIENIHETLKVDEEVQVQVVDLDEFTGKASLSIRTLEEEKYQFPRRRRFSSDRFNYGFAPFRRMLPIWTGEALHYLKKKK
>NC_014251.1|WP_001245190.1|1638250_1639735_+|helix-turn-helix-domain-containing-protein
MRNLLSTKVQRQLRLMENLIQNRNWMKLHELAEKLGCTERILKSDLNELRIAFPSINIQSSVNGIMIDLEVNTSVEDIYQYFLANSQSFQLLEYMFFNEGLPIYRTIENLYFSSANLYRLGRNITKVLSSQFQIELSFTPSEIRGNEIDIRYFFAQYFSERYYFLDWPFPDLPEEDLTEFADFFYKITNYPMRFSIYRMYKLMIAISIHRVKNGHFIDLPNHFYKEYYPLLKSIPNFQETLAYFSKHFGLEMTPDTIAQIFISFLQNDIFLDPQEFFNSLEDNSQARYSYQLLSQILERLSKQYKITFTNHDELIWHLHNTAFFERQEIFSTPILFEQKALTIKKFEVYFPDFMGSARQELAQYRQAIGQHDHPEQLEHLMYTILTHAENLSTQLLENRPPIKVLIISNFDHAISLTFVDMLSYYCNNRFTFDIWDELKTSPEILNQTDYDIIVSNFYIPGITKKFICRNHLSIINLVNHLNTLSNEIHLSNTL
>NC_014251.1|WP_000697775.1|1639785_1640514_-|peroxide-stress-protein-YaaA
MKILIPTAKEMNTDLPSIEAIPLKPESQTVLDALALYSASQLESFYKVSAEKAAEEFQNIQALKRQTAQHYPALKLFDGLMYRNIKRDKLTEAEQDYLENHVFITSALYGVVPALSPMAPHRLDFLMKLKVAGKTLKSHWKAVYDEALKKEEVIFSLLSSEFETVFSKEIRAKMVTFKFMEDRGGQLKIHSTISKKARGAFLTALIENQVQTVGEARRLNFAGFVYREDLSQPQGLVFVKEV
>NC_014251.1|WP_000508269.1|1640592_1640757_-|YczI-family-protein
MGFYLMVASMLLGLLALKIGFSQFKEKKDKFLSILTSLAGTALVLVAVWLGWPK
>NC_014251.1|WP_000822863.1|1640822_1642418_-|hypothetical-protein
MKRIVFELIFIATTWYIFLPPLNLTSWEFLFFLCGHLLVVAILFGFGKGINLVKTVHVRHGKAEAALNLEGFKINRLGKILLASIGGILLLAALVSLVTSSMFQAKNYANVVTVTEKDFTEFPKSDTSKVPILDRSTAEKIGDRYLGSLTDKVSQYVAADTYTQLTIDGKPYRVTPLEYADPIKWFNNQAKGIGEYIKVDMVTGNADLVDLKTPIKYSDSEYFNRDVKRHLRLKYPTKIFKTPSFEVDDEGNPFYVATVYQKQFGLAVPRPASVIILDATNGETKEYSLSDVPEWVDRIYPAEETIEQINYNGKYKDGFLNAMISKKNVTQTTNGYNYLSIGNDIYLYTGVTSANADESNLGFILENMRTGEITKYSLASATEESARESAEGAVQEKSYKATFPILINLNDKPLYIMGLKDNAGLVKEYALVDAVEYQNVIVATTVEEMLSKYANKNDLEIDNATTESIKGVVADLKSAVIKGDTVYFFKVDGKIYKVKASVSDDLPYLENGKTFEGQVGKDNYLKTFKLR
>NC_014251.1|WP_000412220.1|1642429_1642840_-|peptide-deformylase
MEKKIVKDILFLSQVSQPASQEDLYLARDLQDTLLANRDTCVGLAANMIGVQKRVIIFNLGLVPVVMFNPVLLSFEGSYEAEEGCLSLVGVRSTKRYETIRLAYRDSKWQEQTITLTGFPAQICQHELDHLEGRII
>NC_014251.1|WP_001277403.1|1642955_1643747_-|glutathione-dependent-disulfide-bond-oxidoreductase
MSAYQLPTVWQDEASNQGAFTGLNRPTAGARFEQNLPKGEQAFQLYSLGTPNGVKVTILLEELLEAGFKEAAYDLYKIAIMDGDQFGSDFVKLNPNSKIPALLDQSGTENVRVFESAHILLYLAEKFGAFLPSNPVEKVEVLNWLFWQAGAAPFLGGGFGHFFNYAPEKLEYPINRFTMEVKRQLDLLDKELAQKPYIAGNDYTIADIAIWSWYGQLVQGNLYQGSAKFLDASSYQNLVKWAEKIANRPAVKRGLEVTYTEIK
>NC_014251.1|WP_000032458.1|1643759_1646456_-|cation-translocating-P-type-ATPase
MSKEQKRQAFYTQSPEEVLQAVDATEQGLSSSEAEKRLAEFGHNELEEGEKRSILVKFIEQFKDLMIIILVAAAILSVVTSGGEDIADAIIILAVVIINAAFGVYQEGKAEEAIEALKSMSSPVARVLRDGHMAEIDSKELVPGDIVALEAGDVVPADLRLIEANSLKIEEAALTGESVPVEKDLSVELATDAGIGDRVNMAFQNSNVTYGRGMGVVVNTGMYTEVGHIAGMLQDADETDTPLKQNLNNLSKVLTYAILVIALVTFVVGVFIQGKNPLGELLTSVALAVAAIPEGLPAIVTIVLSLGTQVLAKRHSIVRKLPAVETLGSTEIIASDKTGTLTMNKMTVEKVFYDAVLHDSADDIELGLEMPLLRSVVLANDTKIDVEGNLIGDPTETAFIQYALDKGYDVKGFLEKYPRVAELPFDSDRKLMSTVHPLPDGRFLVAVKGAPDQLLKRCLLRDKAGDIAPIDEKVTNLIHTNNSEMAHQALRVLAGAYKIIDSIPENLTSEELENDLIFTGLIGMIDPERPEAAEAVRVAKEAGIRPIMITGDHQDTAEAIAKRLGIIDANDTEGHVLTGAELNELSDEEFEKVVGQYSVYARVSPEHKVRIVKAWQKQGKVVAMTGDGVNDAPALKTADIGIGMGITGTEVSKGASDMILADDNFATIIVAVEEGRKVFSNIQKTIQYLLSANTAEVLTIFLSTLFGWDVLQPVHLLWINLVTDTFPAIALGVEPAEPGVMNHKPRGRKASFFSGGVLSSIIYQGVLQAALVMSVYGLAIAYPVHVGDNHAIHADALTMAFATLGLIQLFHAYNVKSVYQSILTVGPFKSKTFNWSILVSFILLMATIVVEPLEGIFHVTKLDLSQWGIVMAGSFSMIIIVEIVKFIQRKLGFDKNAI
>NC_014251.1|WP_000813916.1|1646759_1647944_+|CDF-family-manganese-efflux-transporter-MntE
MKQSISNLKLAERGAIISISTYLILSAAKLAAGHLLHSSSLVADGFNNVSDIIGNVALLIGIRMARQPADRDHRFGHWKIEDLASLITSIIMFYVGFDVLRDTIQKILSREETVIDPLGATLGIISAAIMFVVYLYNTRLSKKSNSKALKAAAKDNLSDAVTSLGTAIAILASSFNYPIVDKLVAIIITFFILKTAYDIFIESSFSLSDGFDDRLLEDYQKAIMEIPKISKVKSQRGRTYGSNIYLDITLEMNPDLSVFESHEIADQVESMLEERFGVFDTDVHIEPAPIPEDEILDNVYKKLLMREQLIDQGNQLEELLTDDFVYIRQDGEQMDKEAYKTKKELNSAIKDIQITSISQKTKLICYELDGIIHTSIWRRHETWQNIFHQETKKE
>NC_014251.1|WP_001279133.1|1648086_1649958_-|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MSDFIVEKLSKSVGDKTVFRDISFIIHDLDRIGLIGVNGTGKTTLLDVLSGVSGFDGDVSPFSAKNDYQIGYLTQDPDFDDRKTVLDTVLSSELKEIQLIREYELIMLDYSEDKQARLERVMAEMDSLQAWEIESQVKTVLSKLGIQDLSTPVGELSGGLRRRVQLAQVLLGNHDLLLLDEPTNHLDIAIIEWLTLFLKNSKKTVLFITHDRYFLDALSTRIFELDRAGLTEYQGNYQDYVRLKAEQDERDAALLHKKEQLYKQELAWMRRQPQARATKQQARINRFHDLKKEVSGSSAETDLTMNFETSRIGKKVIEFQAVSFAYENKPILQDFNLLVQAKDRIGIVGDNGVGKSTLLNLIAGSLEPTKGQVVIGETVRIAYFSQQIEGLDESKRVINYLQEVAEEVKTSGGSTTSIAELLEQFLFPRSTHGTLIEKLSGGEKKRLYLLKLLLEKPNVLLLDEPTNDLDIATLTVLENFLQGFAGPVLTVSHDRYFLDKVATKILAFEDGKIRPFFGHYTDYLDEKAFETDMANQVQKVEKEKVVKVREDKKRMTYQEKQEWASIEGDIETLEKRIAAIEEEMQANGSDFGKLATLQKELDEKNEALLEKYERYEYLSEFDS
>NC_014251.1|WP_001138814.1|1649954_1651139_-|CCA-tRNA-nucleotidyltransferase
MPSEFQKALPVLEKIKEAGFEAYFVGGSVRDALLHSPIHDVDIATSSYPEETKQIFPRTADIGIEHGTVLVLDGDEEYEVTTFRTEDVYVDYRRPSAVSFVRSLEEDLKRRDFTVNAFALDETGEIVDLFHGLEDLEKQVLRAVGVASERFNEDALRIMRGFRFQASLGFALEPETFKAMKTLTPLLEKISVERTFVEFDKLLLAPFWRRGLASMIESQAYDYLPDMASSQDKLNRLFDLETDFTFESSEQAWAALLWALEIENAQSLLKSWKTSRQFAKQVQDLLIILALRENGELSKRDCYRFDIDLLLQAENLRQAQGKEVNPQAITEKYQSLTIHDKKEIQINGGILIKEYGYQPGPDLGEILTEIEFAIVDGELENNREAIHAYLREKK

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Crispr_ID: NC_014251_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_014251_3

1858578-1858662

Orphan

Consensus_repeat	Method
CTTTTTTTGAAACGTTTCATTTTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_014251_3

>merge|NC_014251|3|1858578-1858662|CRISPRCasFinder
CTTTTTTTGAAACGTTTCATTTTTTCTATAAAAGATAGCGCTTGGCGCTGTCTTTTTATTTCTTTTTTTGAAACGTTTCATTTTT

>NC_014251|3|3|1858578-1858662|CRISPRCasFinder
CTTTTTTTGAAACGTTTCATTTTT	TCTATAAAAGATAGCGCTTGGCGCTGTCTTTTTATTT
CTTTTTTTGAAACGTTTCATTTTT

Protein	Signature genes	Signature genes Name	Protein_function
NC_014251.1\|WP_000818079.1\|1851448_1851688_-\|hypothetical-protein	unknown	unknown	unknown
NC_014251.1\|WP_000961810.1\|1850299_1850752_-\|type-II-toxin-antitoxin-system-HicB-family-antitoxin	unknown	unknown	gnl\|CDD\|224514
NC_014251.1\|WP_001113206.1\|1851957_1853229_+\|replication-associated-recombination-protein-A	unknown	unknown	gnl\|CDD\|237355
NC_014251.1\|WP_001205280.1\|1860081_1861563_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|285470
NC_014251.1\|WP_000257114.1\|1849538_1850009_-\|DUF3013-family-protein	unknown	unknown	gnl\|CDD\|337951
NC_014251.1\|WP_000109957.1\|1863679_1863883_+\|CsbD-family-protein	unknown	unknown	gnl\|CDD\|225777
NC_014251.1\|WP_000481747.1\|1865636_1866788_-\|XRE-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225412
NC_014251.1\|WP_001048906.1\|1851104_1851284_-\|hypothetical-protein	unknown	unknown	unknown
NC_014251.1\|WP_000030213.1\|1862253_1862820_+\|alkaline-shock-response-membrane-anchor-protein-AmaP	unknown	unknown	gnl\|CDD\|380217
NC_014251.1\|WP_000064115.1\|1863040_1863649_+\|Asp23/Gls24-family-envelope-stress-response-protein	unknown	unknown	gnl\|CDD\|224221
NC_014251.1\|WP_000155421.1\|1864409_1864856_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|224584
NC_014251.1\|WP_000502563.1\|1853775_1855095_-\|glycoside-hydrolase-family-32-protein	unknown	unknown	gnl\|CDD\|224536
NC_014251.1\|WP_001084979.1\|1857650_1858568_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226666
NC_014251.1\|WP_000230204.1\|1858718_1859720_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_014251.1\|WP_001132282.1\|1850788_1850968_-\|type-II-toxin-antitoxin-system-HicA-family-toxin	unknown	unknown	gnl\|CDD\|377942
NC_014251.1\|WP_000565017.1\|1864925_1865585_+\|prepilin-peptidase	unknown	unknown	gnl\|CDD\|377700
NC_014251.1\|WP_000669748.1\|1855104_1856721_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270299
NC_014251.1\|WP_000797961.1\|1856749_1857640_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_014251.1\|WP_000455066.1\|1862831_1863002_+\|DUF2273-domain-containing-protein	unknown	unknown	gnl\|CDD\|227834
NC_014251.1\|WP_001809002.1\|1862005_1862170_+\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	unknown	unknown	gnl\|CDD\|225170

Protein	Function_ID	Function_description	E-value
NC_014251.1\|WP_000257114.1\|1849538_1850009_-\|DUF3013-family-protein	gnl\|CDD\|337951	pfam11217, DUF3013, Protein of unknown function (DUF3013). This bacterial family of proteins with unknown function appear to be restricted to Firmicutes.	1.48214e-64
NC_014251.1\|WP_000961810.1\|1850299_1850752_-\|type-II-toxin-antitoxin-system-HicB-family-antitoxin	gnl\|CDD\|224514	COG1598, COG1598, Predicted nuclease of the RNAse H fold, HicB family [General function prediction only].	1.2282e-11
NC_014251.1\|WP_001113206.1\|1851957_1853229_+\|replication-associated-recombination-protein-A	gnl\|CDD\|237355	PRK13342, PRK13342, recombination factor protein RarA; Reviewed.	0
NC_014251.1\|WP_001205280.1\|1860081_1861563_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|285470	pfam08270, PRD_Mga, M protein trans-acting positive regulator (MGA) PRD domain. Mga is a DNA-binding protein that activates the expression of several important virulence genes in group A streptococcus in response to changing environmental conditions. This corresponds to the PRD like region.	1.09342e-73
NC_014251.1\|WP_000109957.1\|1863679_1863883_+\|CsbD-family-protein	gnl\|CDD\|225777	COG3237, COG3237, Uncharacterized protein conserved in bacteria [Function unknown].	1.20386e-07
NC_014251.1\|WP_000481747.1\|1865636_1866788_-\|XRE-family-transcriptional-regulator	gnl\|CDD\|225412	COG2856, COG2856, Predicted Zn peptidase [Amino acid transport and metabolism].	3.34794e-47
NC_014251.1\|WP_000030213.1\|1862253_1862820_+\|alkaline-shock-response-membrane-anchor-protein-AmaP	gnl\|CDD\|380217	NF033218, anchor_AmaP, alkaline shock response membrane anchor protein AmaP. The founding member of this family, AmaP (Asp23 membrane anchoring protein), is related to Asp23 through part of its length, but includes a highly hydrophobic N-terminal region that should make it an integral membrane protein. Asp23 (alkaline shock protein of 23 kDa), described in PMID:7864904, is a cytosolic protein in Staphylococcus aureus, strongly induced by a pH shift from 7 to 10, and also recruited to the membrane. AmaP appears to be the partner protein with an integral membrane segment and the ability to anchor Asp23 to the membrane. This model was built to identify full-length homologs of AmaP, while excluding Asp23. Some but not all members of this family score above the cutoffs of Pfam model version PF03780.11, but full-length homologs of Asp23 score considerably higher. Asp23 family members previously were known as DUF322.	7.65552e-46
NC_014251.1\|WP_000064115.1\|1863040_1863649_+\|Asp23/Gls24-family-envelope-stress-response-protein	gnl\|CDD\|224221	COG1302, COG1302, Uncharacterized protein conserved in bacteria [Function unknown].	1.35166e-33
NC_014251.1\|WP_000155421.1\|1864409_1864856_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	3.17507e-08
NC_014251.1\|WP_000502563.1\|1853775_1855095_-\|glycoside-hydrolase-family-32-protein	gnl\|CDD\|224536	COG1621, SacC, Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism].	1.78522e-177
NC_014251.1\|WP_001084979.1\|1857650_1858568_-\|sugar-ABC-transporter-permease	gnl\|CDD\|226666	COG4209, LplB, ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism].	1.73729e-138
NC_014251.1\|WP_000230204.1\|1858718_1859720_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	2.86275e-99
NC_014251.1\|WP_001132282.1\|1850788_1850968_-\|type-II-toxin-antitoxin-system-HicA-family-toxin	gnl\|CDD\|377942	pfam07927, HicA_toxin, HicA toxin of bacterial toxin-antitoxin,. HicA_toxin is a bacterial family of toxins that act as mRNA interferases. The antitoxin that neutralizes this is family HicB, pfam15919.	1.54972e-09
NC_014251.1\|WP_000565017.1\|1864925_1865585_+\|prepilin-peptidase	gnl\|CDD\|377700	pfam06750, DiS_P_DiS, Bacterial Peptidase A24 N-terminal domain. This family is found at the N-terminus of the pre-pilin peptidases (pfam01478). It's function has not been specifically determined; however some of the family have been characterized as bifunctional, and this domain may contain the N-methylation activity (EC:2.1.1.-). It consists of an intracellular region between a pair of transmembrane. This region contains an invariant proline and two almost fully conserved disulphide bridges - hence the name DiS-P-DiS. The cysteines have been shown to be essential to the overall function of the enzyme in, but their role was incorrectly ascribed.	1.48288e-26
NC_014251.1\|WP_000669748.1\|1855104_1856721_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270299	cd13581, PBP2_AlgQ_like_2, Periplasmic-binding component of alginate-specific ABC uptake system-like; contains the type 2 periplasmic binding fold. This subgroup includes uncharacterized periplasmic-binding proteins that are closely related to high molecular weight (HMW) alginate bining proteins (AlgQ1 and AlgQ2) found in gram-negative soil bacteria. The HMW alginate uptake system is composed of a novel pit formed on the cell surface and a pit-dependent ATP-binding cassette (ABC) transporter in the inner membrane. The transportation of HMW alginate from the pit to the ABC transporter is mediated by periplasmic HMW alginate-binding proteins (AlgQ1 and AlgQ2). Alginate is an anionic polysaccharide that is made up of alpha-L-mannuronate and its 5'-epimer, alpha-L-guluronate. Alginate is present in the cell walls of brown seaweeds, where it forms a viscous gum by binding water. Alginate is also produced by two bacteria genera Pseudomonas and Azotobacter. AlgQ1 and AlgQ2 belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. However, unlike other bacterial periplasmic-binding proteins that deliver small solutes to ABC transporters, AlgQ1/2 can bind a macromolecule and may have specificity for either sugar or a certain type of polysaccharide.	0
NC_014251.1\|WP_000797961.1\|1856749_1857640_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	4.20755e-67
NC_014251.1\|WP_000455066.1\|1862831_1863002_+\|DUF2273-domain-containing-protein	gnl\|CDD\|227834	COG5547, COG5547, Small integral membrane protein [Function unknown].	9.45975e-16
NC_014251.1\|WP_001809002.1\|1862005_1862170_+\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	gnl\|CDD\|225170	COG2261, COG2261, Predicted membrane protein [Function unknown].	6.92661e-06

>NC_014251.1|WP_001084979.1|1857650_1858568_-|sugar-ABC-transporter-permease
MNSKAKQVSLWERIKKQKLLLLMTVPGLVLTFIFKYIPMYGVLIAFKDYNPLKGILGSDWIGFSEFTKFISSPNFGILLANTLKLSIYGLLLGFLPPIILAIMLNQLLSEKVKKRIQLILYAPNFISVVVIVGMIFLFFSVGGPINNFLSMFGMKADFLTNPDFFRPLYIFSGIWQGMGWASTLYTATLVNVDPALVEAARLDGANIFQRIWHIDIPALKPIMVIQFVLAAGGIMNVGYEKAFLMQTSLNLPTSEIISTYVYKVGLVSGDYSYSTAVGLFNAVINVVLLVAVNQIVKRMNNGEGI
>NC_014251.1|WP_000797961.1|1856749_1857640_-|carbohydrate-ABC-transporter-permease
MKNSIMDTKFDRRILLLNKIIIVFIVLMTLLPLLYIVVASFMDPKVLVSRGISFNPADWTVEGYQRVFSDQSILRGFINSLLYSFGFAALTVLLSVFTAYPLSKKDLVGRRWINYFLIVTMFFGGGLVPTYLLVKELGMLNTPWAIIVPGAVNVWNIILARAYFQGLPEELVEAAVIDGANDLQIFFKIMLPLAKPIMFVLFLYAFVGQWNSYFDAMIYIKDPNLEPLQLVLRKILIQSQPGQDMIGAQAAMNEMKRLAELIKYATIVISSLPLIVMYPFFQKYFDKGIMAGSLKG
>NC_014251.1|WP_000669748.1|1855104_1856721_-|ABC-transporter-substrate-binding-protein
MKFKTFSKSAVLLTASLAVLAACGSKNTASSPDYKLEGVTFPLQEKKTLKFMTASSPLSPKDPNEKLILQRLEKETGVHIDWTNYQSDFAEKRNLDISSGDLPDAIHNDGASDVDLMNWAKKGVIIPVEDLIDKYMPNLKKILDEKPEYKALMTAPDGHIYSFPWIEELGDGKESIHSVNDMAWINKDWLKKLGLEMPKTTDDLIKVLEAFKNGDPNGNGEADEIPFTFISGNGNEDFKFLFAAFDIGDNDDHLVVGNDGKVDFTADNDNYKEGVKFIRQLQEKGLIDKEAFEHDWNSYIAKGHDQKFGVYFTWDKNNVTGSNESYDVLPVLAGPSGQKHVARTNGMGFARDKMVITSVNKNLELTAKWIDAQYAPLQSVQNNWGTYGDDKQQNIFELDQASNSLKHLPLNGTAPAELRQKTEVGGPLAILDSYYGKVTTMPDDAKWRLDLIKEYYVPYMSNDNNYPRVFMTQEDLDKIAHIEADMNDYIYRKRAEWIVNGNIDTEWDDYKKELEKYGLSDYLAIKQKYYDQYQANKN
>NC_014251.1|WP_000502563.1|1853775_1855095_-|glycoside-hydrolase-family-32-protein
MGDKKYTVEKANRFIAENKHLVNTQYKPEEHFSAEIGWINDPNGFVYFRGEYHLFYQFYPYDSVWGPMHWGHAKSKDLVTWEHLPVALAPDQDYDRNGCFSGSAIVKDDRLWLMYTGHIEEKTGVRQVQNMAFSDDGIHFEKISQNPVVTGTDLPDELIAADFRDPKLFEKDGRYYSVVAVKHMDNVGCIVLLGSDNLVEWQFESIFLKGGEHQGFMWECPDYFELDGKDCLIMSPMRYQREGDSYHNINSSLLFTGKVDWREKRFIPESVQEIDHGQDFYAPQTLLDDQNRRILIAWMQTWGRTLPTHDQEHKWACAMTLPRILRLEDGKLRQFPVKKGQYQIQIDKDCHYHLGNDIDYLEFGYDSNAQQVYIDRSHLIQKILGEEEQDTSRRYVDIEAKELEVVLDKNSIEIFVNQGEASLTATYYLTVPAELSRID
>NC_014251.1|WP_001113206.1|1851957_1853229_+|replication-associated-recombination-protein-A
MPDNLALRMRPKTIDQVIGQEHLVGPGKIIRRMVEANRLSSMILYGPPGIGKTSIASAIAGTTKYAFRTFNATVDSKKRLQEISEEAKFSGGLVLLLDEIHRLDKTKQDFLLPLLESGLVIMIGATTENPFFSVTPAIRSRVQIFELEPLSNQDVKEALQIALSNPERGFDFPIELDEDALDFIATSTNGDLRSAFNSLDLAVLSTPENDEGIRHITLDIMENSLQRSYITMDKDGDGHYDVLSALQKSIRGSDVDASLHYAARLIEAGDLPSLARRLTVIAYEDIGLANPEAQIHTVTALDAAQKIGFPEARILIANVVIDLALSPKSNSAYVAMDKALTDLKTSGHLPIPRHLRDGHYSGSKELGNAQDYLYPHNYPGNWVKQDYLPEKIRNHHYFQAEDTGKYERALAQRKEAIDRLRKI
>NC_014251.1|WP_000818079.1|1851448_1851688_-|hypothetical-protein
MKREVISNGNDGPSQEILIFTKQIRHWILSDQVISGKRKLFFREDTPKEILDLYENIKSKLDFAYQEVYSNNGLKKYEK
>NC_014251.1|WP_001048906.1|1851104_1851284_-|hypothetical-protein
MNLIFEEYQFVKIGDKKYRVRSVPMIHSTPPQSVLDRDTFTIDYTDDELLDKEAVFTTH
>NC_014251.1|WP_001132282.1|1850788_1850968_-|type-II-toxin-antitoxin-system-HicA-family-toxin
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERLITIPHGELNKYTERGIRKQAGL
>NC_014251.1|WP_000961810.1|1850299_1850752_-|type-II-toxin-antitoxin-system-HicB-family-antitoxin
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPFKDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA
>NC_014251.1|WP_000257114.1|1849538_1850009_-|DUF3013-family-protein
MATYGFLDVLEEELDKNFPFDFEISWDKRNYAVEVSFLLEAQNAAGVEMVDEDGEVSSDDILFEEAVLFYNPAKSTVNEEDYLTVIPYLPKKGFSREFLAYFALFLKDTAEVGLDALMDFLEDPEAEEFVMEWNQEVFEEGKVGLEEGEFYPYPKY
>NC_014251.1|WP_000230204.1|1858718_1859720_-|LacI-family-DNA-binding-transcriptional-regulator
MVEQRKSITMKDVALEAGVSVGTVSRVINKEKGIKEVTLKKVEQAIKTLNYIPDYYARGMKKNRTETIAIIVPSIWHPFFSEFAMHVENEVYKRNNKLLLCSINGTNREQDYLEMLRHNKVDGVVAITYSPIEHYLTSGIPFVSIDRTYSDIAIPCVSSDNDAGGREAAKQLISKGCQHLAFVGGHNTTINETKRRRISFEKYVQEHKIPLSIFDLDETVTDYYGKLESFLEENSSIDGIFTINDFTALDVIEILKKNGKRIPHDVQIIGYDGIKMAGDRDYLLSTIEQPLEEMAKEAVRILFDIIDGKTVNLQTILPVKFVEGKTTKNENKS
>NC_014251.1|WP_001205280.1|1860081_1861563_-|helix-turn-helix-domain-containing-protein
MRDLLSKKSHRQLELLELLFEHKRWFHRSELAELLNCTERAVKDDLSHVKSAFPDLIFHSSTNGIRIINTDDSDIEMVYHHFFKHSTHFSILEFIFFNEGCQAESICKEFYISSSSLYRIISQINKVIKRQFQFEVSLTPVQIIGNERDIRYFFAQYFSEKYYFLEWPFENFSSEPLSQLLELVYKETSFPMNLSTHRMLKLLLVTNLYRIKFGHFMEVDKDSFNDQSLDFLMQAEGIEGVAQSFESEYNISLDEEVVCQLFVSYFQKMFFIDESLFMKCVKKDSYVEKSYHLLSDFIDQISVKYQIEMENKDNLIWHLHNTAHLYRQELFTEFILFDQKGNTIRNFQNIFPKFVSDIKKELSHYLETLEVCSSSMMVNHLSYTFITHTKHLVINLLQNQPKLKVLVMSNFDQYHAKFVAETLSYYCSNNFELEVWTELELSKESLEDSPYDIIISNFIIPPIENKRLIYSNNINTVSLIYLLNAMMFIRLDE
>NC_014251.1|WP_001809002.1|1862005_1862170_+|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein
MGIIANVFAGLVGAYAGQSLLGSWGPSIAGMALLPSIVGAAIVITVVSFFTGRK
>NC_014251.1|WP_000030213.1|1862253_1862820_+|alkaline-shock-response-membrane-anchor-protein-AmaP
MSKAKKICFIIFCILILTIFLPVLIDYHQVSDLGIHLLSWRQNSVVEFYLARYVFWGTVVLSTLVLLSILVVMFYPKRYLEIQLETKNDTLKLKNSAIEGFVRSLVSDHRLIKNPTVHVNLRKNKCFVHVEGKILPSDNIADRCQIIQNEITNGLKQFFGIERQVKLEVAVKNYQPKPQNKKTVSRVK
>NC_014251.1|WP_000455066.1|1862831_1863002_+|DUF2273-domain-containing-protein
MEWLKQYRYPIIAGLIGVFLACLIVSFGFFKTIFVLILGALGVAAGLYIEKNYIDK
>NC_014251.1|WP_000064115.1|1863040_1863649_+|Asp23/Gls24-family-envelope-stress-response-protein
MSNEKNTNTNVEKKDATVVAHEIKGELTYEDKVIQKIIGLSLENVSGLLGIDGGFFSNLKEKIVNSDDVTSGVNVEVGKTQVAVDLNVIVEYQKNVPALYSEIREIVSSEVAKMTDLEIVEINVNVVDIKTKEQHEADSVSLQDRVSDVAESTGEFTSEQFEKAKSGLGSGFSTVQEKVSEGVEAVKGAANGVVSHENTRVN
>NC_014251.1|WP_000109957.1|1863679_1863883_+|CsbD-family-protein
MSVEEKLNQAKGSIKEGVGKAIGDEKMEKEGAAEKVVSKVKEVAEDAKDAVEGAVEGVKNMLSGDDK
>NC_014251.1|WP_000155421.1|1864409_1864856_-|GNAT-family-N-acetyltransferase
MTIRFEEKVSIENAQLVCQWSNSLGKVFQEQWMGPRIPFPLTLQALEGVFSIFDEQEFVGLIQKIRLEDSNLHIGRFFINPQKQEQDLGSQALRKFVSLAFENEDIDSISLNVFEANQRAQNLYQKEGFEIVQMVEAPVRKYSRLKLE
>NC_014251.1|WP_000565017.1|1864925_1865585_+|prepilin-peptidase
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLGLLFLLYSWELLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILIASSGWNLVMVSFLALGILAHFIDIRMGAGDFLFLASCALVFSVTELLILIQFASATGILAFILQKKKERLPFVPFLLLATCLIIFGKLLLV
>NC_014251.1|WP_000481747.1|1865636_1866788_-|XRE-family-transcriptional-regulator
MFNGRVLKELRLLNGLSRAELAQRINLTEQAIWQFESNETKPKLSTKMHLANQFHVDLTYFEQEEESIRFDSSVIAFRNADLATRKTIDIQTMYLHKVDSLIDYFESFIIIPNIIIHDLSNVVSESYHKGESIEELALYAREKLGISKDNHDLLYKLERSGIYIVERLINGQADAYSAWSKLGRPYIVLGTNKSSVRRNFDLAHELGHILLHKYKDMNEDGDRLEQEANYFASCFLLPKEEFLVKFEERVGKRVSNPDSYILLKSDLNVSIQALEYRAFKLGLLTPKQHSYFYRQIAQKGYKMIEPLDDQIFVKKPSKVKSILDVVLSNHLVSLATIMSKQSIRLQFISEIFSVEMKFFDQYQEDRRTDRFDNIIPLYKRNNL

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_014251_1	1.1\|1279998\|38\|NC_014251\|CRISPRCasFinder	1279998-1280035	38	KY065475	Streptococcus phage IPP35, complete genome	23044-23081	4	0.895
NC_014251_1	1.1\|1279998\|38\|NC_014251\|CRISPRCasFinder	1279998-1280035	38	MK448453	Streptococcus satellite phage Javan360, complete genome	13985-14022	5	0.868

1. spacer 1.1|1279998|38|NC_014251|CRISPRCasFinder matches to KY065475 (Streptococcus phage IPP35, complete genome) position: , mismatch: 4, identity: 0.895

agatattatggagcctattttattgtagaaaaaaaggg	CRISPR spacer
agatattatggagcctatttttgtgtagaaaaaaagtc	Protospacer
*********************  *************

2. spacer 1.1|1279998|38|NC_014251|CRISPRCasFinder matches to MK448453 (Streptococcus satellite phage Javan360, complete genome) position: , mismatch: 5, identity: 0.868

agatattatggagcctattttattgtagaaaaaaaggg	CRISPR spacer
gaatattatggagcctattttgttgtagaaaaaaagtc	Protospacer
..*******************.**************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

224105 : 232859

Streptococcus_phage(33.33%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000510412.1\|224105_224945_-	energy-coupling factor transporter ATPase	W8CYL7	Bacillus_phage	1.1e-15	32.6
WP_000835715.1\|224929_225757_-	energy-coupling factor transporter ATPase	G9BWD6	Planktothrix_phage	2.8e-22	32.9
WP_000712136.1\|225753_226299_-	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase	NA	NA	NA	NA
WP_001227958.1\|226309_227131_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_000170193.1\|227172_228456_-	insulinase family protein	A0A1E1EST3	Acanthamoeba_castellanii_mimivirus	7.1e-17	29.5
WP_000424257.1\|228452_229703_-	insulinase family protein	A0A1X9I714	Streptococcus_phage	6.0e-93	42.1
WP_000455903.1\|229861_230230_+	S4 domain-containing protein YaaA	A0A1X9I5V8	Streptococcus_phage	7.0e-18	57.3
WP_000266662.1\|230232_231330_+	DNA replication/repair protein RecF	NA	NA	NA	NA
WP_000073428.1\|231380_232859_-	IMP dehydrogenase	A0A1V0SHK8	Klosneuvirus	2.2e-94	40.5

DBSCAN-SWA_2

258772 : 267373

Streptococcus_phage(57.14%)

integrase

attL 259003:259017|attR 273845:273859

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000424684.1\|258772_259378_-	Rha family transcriptional regulator	A0A192Y918	Salmonella_phage	6.8e-18	34.1
259003:259017	attL	NA	NA	NA	NA
WP_013193355.1\|259399_259777_-	hypothetical protein	NA	NA	NA	NA
WP_001241280.1\|259851_260043_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_001814778.1\|260246_260963_+	helix-turn-helix domain-containing protein	A0A1S5SFG5	Streptococcus_phage	2.6e-77	63.0
WP_000666926.1\|260981_261650_+	zinc ribbon domain-containing protein	A0A141DZS3	Streptococcus_phage	8.4e-78	74.1
WP_000222518.1\|261788_262457_+	Fic family protein	D7RWK9	Brochothrix_phage	9.2e-08	24.6
WP_000255647.1\|262919_263378_-	hypothetical protein	A0A1X9I5V5	Streptococcus_phage	5.6e-25	46.0
WP_000417039.1\|264800_265106_+	protein rep	NA	NA	NA	NA
WP_000422980.1\|265210_265771_+	multidrug DMT transporter	A0A1W6JPJ7	Morganella_phage	4.6e-21	56.1
WP_000704676.1\|266206_267373_+\|integrase	site-specific integrase	A0A1X9I5Y5	Streptococcus_phage	2.0e-103	51.5
273845:273859	attR	NA	NA	NA	NA

DBSCAN-SWA_3

304488 : 315799

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000668291.1\|304488_306642_+	peptide cleavage/export ABC transporter	W8CYL7	Bacillus_phage	1.0e-44	28.0
WP_000801611.1\|306654_308004_+	HlyD family secretion protein	NA	NA	NA	NA
WP_000043310.1\|308173_308881_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A1D8KNF0	Synechococcus_phage	1.3e-41	39.2
WP_000361217.1\|308937_312663_+	phosphoribosylformylglycinamidine synthase	A6N228	Microbacterium_phage	1.6e-37	25.8
WP_000220632.1\|312755_314198_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	5.7e-55	35.1
WP_000182580.1\|314234_315257_+	phosphoribosylformylglycinamidine cyclo-ligase	A0A1D7SE90	Cyanophage	7.3e-65	44.2
WP_000717501.1\|315253_315799_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	9.7e-24	35.0

DBSCAN-SWA_4

357160 : 398595

Streptococcus_phage(40.0%)

bacteriocin,transposase,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001814919.1\|357160_358507_+\|transposase	IS1380-like element ISSpn5 family transposase	A0A1X9I6F6	Streptococcus_phage	4.5e-78	40.0
WP_001257240.1\|359578_359776_+	hypothetical protein	NA	NA	NA	NA
WP_000808434.1\|360012_361077_-	membrane protein	NA	NA	NA	NA
WP_001229057.1\|361139_362051_-	DUF4097 family beta strand repeat protein	NA	NA	NA	NA
WP_000198675.1\|362043_362637_-	DUF1700 domain-containing protein	NA	NA	NA	NA
WP_000273854.1\|362623_362950_-	PadR family transcriptional regulator	NA	NA	NA	NA
WP_000744897.1\|363088_364255_-	CynX/NimT family MFS transporter	NA	NA	NA	NA
WP_000096202.1\|364312_365470_+	glycosyltransferase family 2 protein	NA	NA	NA	NA
WP_001035700.1\|365511_367362_+	polysaccharide biosynthesis protein	A0A2P1ELS8	Moumouvirus	7.6e-28	30.5
WP_025168890.1\|367257_367662_-	hypothetical protein	NA	NA	NA	NA
WP_000200898.1\|367711_368344_-	HAD family hydrolase	NA	NA	NA	NA
WP_000500038.1\|368365_369238_-	L-serine ammonia-lyase, iron-sulfur-dependent, subunit alpha	NA	NA	NA	NA
WP_000838912.1\|369246_369918_-	L-serine ammonia-lyase, iron-sulfur-dependent, subunit beta	NA	NA	NA	NA
WP_000836450.1\|370159_370747_+	LysM peptidoglycan-binding domain-containing protein	A0A288TY55	Enterococcus_phage	1.6e-27	56.7
WP_001189285.1\|370798_371119_-	hypothetical protein	NA	NA	NA	NA
WP_073077611.1\|371525_371819_+\|bacteriocin	lactococcin 972 family bacteriocin	NA	NA	NA	NA
WP_000723961.1\|371873_373982_+\|bacteriocin	bacteriocin-associated integral membrane family protein	NA	NA	NA	NA
WP_000571330.1\|373978_374620_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	4.3e-23	34.8
WP_001038474.1\|374826_375633_+	transporter substrate-binding domain-containing protein	NA	NA	NA	NA
WP_099516442.1\|375598_376069_+	argininosuccinate synthase	NA	NA	NA	NA
WP_001189278.1\|376358_376679_-	hypothetical protein	NA	NA	NA	NA
WP_000424418.1\|377437_377806_+\|bacteriocin	SP_0115 family bacteriocin-like peptide	NA	NA	NA	NA
WP_001268157.1\|378204_379068_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_000915345.1\|379533_379872_+	peptidase C39	NA	NA	NA	NA
WP_000973716.1\|380499_380712_+	hypothetical protein	NA	NA	NA	NA
WP_000424467.1\|381127_381490_+	hypothetical protein	NA	NA	NA	NA
WP_000356083.1\|381470_381716_+	hypothetical protein	NA	NA	NA	NA
WP_001814711.1\|381872_382931_+	hypothetical protein	NA	NA	NA	NA
WP_000792250.1\|383246_384224_+	hypothetical protein	NA	NA	NA	NA
WP_000424474.1\|384600_384975_+\|bacteriocin	SPH_0224 family bacteriocin-like peptide	NA	NA	NA	NA
WP_000619753.1\|385182_386085_+	hypothetical protein	NA	NA	NA	NA
WP_000424439.1\|386140_386494_+	hypothetical protein	NA	NA	NA	NA
WP_000072924.1\|386490_387219_+	hypothetical protein	NA	NA	NA	NA
WP_000770314.1\|388353_388593_+	hypothetical protein	M1Q0Z8	Streptococcus_phage	7.2e-16	54.1
WP_001035384.1\|389142_391317_+	pneumococcal surface protein A	NA	NA	NA	NA
WP_001282969.1\|391717_392839_+\|tRNA	tRNA 2-thiouridine(34) synthase MnmA	NA	NA	NA	NA
WP_000193634.1\|392979_393435_+	NUDIX hydrolase	NA	NA	NA	NA
WP_000220964.1\|393444_395358_+\|tRNA	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG	NA	NA	NA	NA
WP_000331983.1\|395710_397390_-	ribonuclease J	NA	NA	NA	NA
WP_000639589.1\|397391_397625_-	DNA-dependent RNA polymerase auxiliary subunit epsilon family protein	NA	NA	NA	NA
WP_000282479.1\|397904_398120_+	hypothetical protein	NA	NA	NA	NA
WP_000974047.1\|398442_398595_-\|bacteriocin	fratricide two-peptide bacteriocin subunit CibB	NA	NA	NA	NA

DBSCAN-SWA_5

443233 : 451059

Streptococcus_phage(75.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001107589.1\|443233_443947_-	helix-turn-helix domain-containing protein	Q708R9	Streptococcus_phage	2.0e-16	51.9
WP_000090006.1\|444099_444330_+	helix-turn-helix transcriptional regulator	X2KUC2	Streptococcus_phage	3.7e-09	47.0
WP_000424665.1\|444345_444972_+	Rha family transcriptional regulator	R9QNB1	Lactococcus_phage	2.1e-30	40.8
WP_000141100.1\|445343_445796_+	hypothetical protein	NA	NA	NA	NA
WP_000174331.1\|445792_445993_+	hypothetical protein	NA	NA	NA	NA
WP_001003774.1\|445994_446210_+	hypothetical protein	NA	NA	NA	NA
WP_000058832.1\|446206_446548_+	hypothetical protein	NA	NA	NA	NA
WP_000492137.1\|446540_446822_+	hypothetical protein	A0A1X9I5U9	Streptococcus_phage	7.9e-30	67.8
WP_000158192.1\|446956_447823_+	primase alpha helix C-terminal domain-containing protein	A0A1X9I6L2	Streptococcus_phage	8.2e-126	75.0
WP_000434359.1\|447875_449345_+	DNA primase family protein	Q9AZI5	Lactococcus_phage	2.3e-64	35.0
WP_000865230.1\|449697_449865_+	hypothetical protein	NA	NA	NA	NA
WP_000173130.1\|449948_450479_+	hypothetical protein	A0A1X9I5U4	Streptococcus_phage	2.8e-36	48.7
WP_000811078.1\|450549_451059_+	hypothetical protein	A0A1X9I5V2	Streptococcus_phage	5.8e-47	53.9

DBSCAN-SWA_6

574254 : 628873

Streptococcus_phage(23.08%)

transposase,integrase,holin,protease

attL 577102:577115|attR 630255:630268

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001063386.1\|574254_576360_+\|protease	ATP-dependent Clp protease ATP-binding subunit	H6X3M6	Enterobacteria_phage	1.0e-116	37.5
WP_000032550.1\|576655_577138_-	S-ribosylhomocysteine lyase	NA	NA	NA	NA
577102:577115	attL	NA	NA	NA	NA
WP_000743611.1\|577232_578717_-	DUF1846 domain-containing protein	NA	NA	NA	NA
WP_001156827.1\|578869_580477_+	alpha-glucosidase	NA	NA	NA	NA
WP_033607364.1\|580641_580809_+	S-ribosylhomocysteinase	NA	NA	NA	NA
WP_000091091.1\|581545_582991_+	LCP family protein	A0A1X9I5X1	Streptococcus_phage	2.8e-134	60.3
WP_000565355.1\|582992_583724_+	capsular polysaccharide biosynthesis protein Cps4B	NA	NA	NA	NA
WP_000664155.1\|583732_584425_+	capsular polysaccharide biosynthesis protein CpsC	A0A1X9I5E1	Streptococcus_phage	3.2e-64	58.5
WP_001142556.1\|584434_585124_+	tyrosine-protein kinase	A0A1X9I5D6	Streptococcus_phage	1.1e-72	63.7
WP_001291065.1\|585138_586500_+	sugar transferase	NA	NA	NA	NA
WP_001005725.1\|586505_587249_+	WecB/TagA/CpsF family glycosyltransferase	NA	NA	NA	NA
WP_001076780.1\|587245_588070_+	LicD family protein	A0A1V0SD50	Indivirus	4.0e-05	38.2
WP_000458862.1\|588071_588950_+	glycosyltransferase family 2 protein	NA	NA	NA	NA
WP_000221687.1\|588950_590285_+	oligosaccharide repeat unit polymerase	NA	NA	NA	NA
WP_001085099.1\|590312_591737_+	hypothetical protein	NA	NA	NA	NA
WP_000723325.1\|591801_592890_+	UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing)	A0A1V0SAG5	Catovirus	1.6e-25	30.2
WP_000676130.1\|593052_593922_+	glucose-1-phosphate thymidylyltransferase RfbA	K7QKA7	Escherichia_phage	2.0e-100	63.2
WP_001282454.1\|593922_594516_+	dTDP-4-dehydrorhamnose 3,5-epimerase family protein	H9NC63	Sphingomonas_phage	3.3e-09	32.3
WP_000141493.1\|594527_595577_+	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	1.4e-71	44.5
WP_000600909.1\|595642_596494_+	dTDP-4-dehydrorhamnose reductase	A0A291LA50	Escherichia_phage	8.6e-27	35.8
WP_000842782.1\|597979_599962_+	peptide ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_001032472.1\|600262_605566_+	YSIRK-type signal peptide-containing protein	NA	NA	NA	NA
WP_001041857.1\|605731_607891_-	PBP1A family penicillin-binding protein	NA	NA	NA	NA
WP_000248773.1\|607887_608484_-	Holliday junction resolvase RecU	A0A1L2JY30	Aeribacillus_phage	1.5e-17	33.9
WP_000179553.1\|608550_609078_+	DUF1273 domain-containing protein	NA	NA	NA	NA
WP_000200644.1\|609147_609489_+	cell division regulator GpsB	NA	NA	NA	NA
WP_000711398.1\|609974_611132_+	class I SAM-dependent RNA methyltransferase	NA	NA	NA	NA
WP_000039290.1\|611144_612539_+	mid-cell-anchored protein MapZ	NA	NA	NA	NA
WP_000158792.1\|612614_614039_+	NADP-dependent phosphogluconate dehydrogenase	M4QQM4	Ostreococcus_lucimarinus_virus	2.7e-41	29.6
WP_000518011.1\|614050_614740_+	response regulator transcription factor	NA	NA	NA	NA
WP_000698035.1\|614837_615800_+\|holin	choline-binding protein CbpC	NA	NA	NA	NA
WP_000771129.1\|615818_616817_+\|holin	choline-binding protein CbpJ	NA	NA	NA	NA
WP_000765684.1\|616934_618167_-	MFS transporter	NA	NA	NA	NA
WP_001809487.1\|618325_618796_-	lanthionine synthetase	NA	NA	NA	NA
WP_000619581.1\|619716_620046_+\|transposase	transposase	NA	NA	NA	NA
WP_000163315.1\|620167_621046_+	mevalonate kinase	NA	NA	NA	NA
WP_000373457.1\|621027_621981_+	diphosphomevalonate decarboxylase	NA	NA	NA	NA
WP_000562413.1\|621967_622975_+	phosphomevalonate kinase	NA	NA	NA	NA
WP_000210618.1\|622958_623969_+	type 2 isopentenyl-diphosphate Delta-isomerase	NA	NA	NA	NA
WP_001224637.1\|624045_624744_+	cell wall-active antibiotics response protein	NA	NA	NA	NA
WP_000743674.1\|624740_625736_+	sensor histidine kinase	NA	NA	NA	NA
WP_000698434.1\|625749_626382_+	response regulator transcription factor	NA	NA	NA	NA
WP_001808881.1\|626382_626625_+	DNA alkylation repair protein	NA	NA	NA	NA
WP_075218974.1\|626549_626861_+	DNA alkylation repair protein	NA	NA	NA	NA
WP_000754501.1\|627301_627541_+	hypothetical protein	NA	NA	NA	NA
WP_073078456.1\|627585_628215_+\|protease	serine protease	NA	NA	NA	NA
WP_000378123.1\|628513_628873_+\|integrase	tyrosine-type recombinase/integrase	C9E2L6	Enterococcus_phage	1.4e-18	41.0
630255:630268	attR	NA	NA	NA	NA

DBSCAN-SWA_7

700432 : 763326

Klosneuvirus(18.18%)

bacteriocin,transposase,tRNA,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001810089.1\|700432_700603_-\|transposase	transposase	NA	NA	NA	NA
WP_000628994.1\|701256_702480_-	ROK family transcriptional regulator	NA	NA	NA	NA
WP_001059636.1\|702646_703969_+	PTS sugar transporter subunit IIC	NA	NA	NA	NA
WP_000236908.1\|703970_705857_+	DUF4838 domain-containing protein	NA	NA	NA	NA
WP_000836781.1\|706024_706369_+	PTS lactose/cellobiose transporter subunit IIA	NA	NA	NA	NA
WP_000429402.1\|706378_707791_+	6-phospho-beta-galactosidase	NA	NA	NA	NA
WP_000359753.1\|707859_709539_+	PTS transporter subunit EIIC	NA	NA	NA	NA
WP_001809506.1\|709664_711104_-	TrkH family potassium uptake protein	NA	NA	NA	NA
WP_000691685.1\|711107_712457_-	Trk system potassium transporter TrkA	NA	NA	NA	NA
WP_001063601.1\|712644_713493_+	S-adenosyl-l-methionine hydroxide adenosyltransferase family protein	NA	NA	NA	NA
WP_000403169.1\|713507_714056_+	ECF-type riboflavin transporter substrate-binding protein	NA	NA	NA	NA
WP_000693286.1\|714062_714320_+	hypothetical protein	NA	NA	NA	NA
WP_000656522.1\|714421_716104_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	3.4e-19	34.4
WP_001148103.1\|716088_716919_+	energy-coupling factor transporter transmembrane protein EcfT	NA	NA	NA	NA
WP_000181373.1\|717111_717615_+\|tRNA	tRNA (cytidine(34)-2'-O)-methyltransferase	NA	NA	NA	NA
WP_000185835.1\|718067_718631_+	ECF transporter S component	NA	NA	NA	NA
WP_000678704.1\|718644_719271_+	phosphatase PAP2 family protein	NA	NA	NA	NA
WP_000867296.1\|719297_719687_+	hypothetical protein	NA	NA	NA	NA
WP_000333653.1\|719691_720141_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_000418402.1\|720268_720856_+	DNA-directed RNA polymerase subunit delta	NA	NA	NA	NA
WP_000105242.1\|721245_722853_+	CTP synthase	A0A1J0FA14	Only_Syngen_Nebraska_virus	8.9e-142	47.0
WP_000026631.1\|723411_725043_-	Na/Pi cotransporter family protein	NA	NA	NA	NA
WP_000795202.1\|725331_730272_+	bacterial Ig-like domain-containing protein	NA	NA	NA	NA
WP_001096743.1\|730361_731558_+	phosphoglycerate kinase	NA	NA	NA	NA
WP_000119900.1\|731693_732221_+	aromatic acid exporter family protein	NA	NA	NA	NA
WP_000659547.1\|732297_732654_+	transcriptional repressor GlnR	NA	NA	NA	NA
WP_001122904.1\|732690_734037_+	type I glutamate--ammonia ligase	NA	NA	NA	NA
WP_001808898.1\|734132_734252_-	hypothetical protein	NA	NA	NA	NA
WP_001220743.1\|734818_736099_+	restriction endonuclease subunit S	A0A1V0SKS6	Klosneuvirus	5.3e-12	29.8
WP_000651177.1\|736155_736953_+	tyrosine-type DNA invertase PsrA	A0A0H4TI16	Erysipelothrix_phage	1.3e-21	28.7
WP_061087362.1\|736963_737569_+	restriction endonuclease subunit S	NA	NA	NA	NA
WP_000187226.1\|737516_739085_-	restriction endonuclease subunit S	A0A1V0SLK8	Klosneuvirus	1.0e-12	25.6
WP_000029054.1\|739084_740548_-	SAM-dependent DNA methyltransferase	NA	NA	NA	NA
WP_000229085.1\|740560_742894_-	DEAD/DEAH box helicase family protein	A0A097BY72	Enterococcus_phage	2.0e-25	28.9
WP_001088687.1\|743501_744011_+	DUF2812 domain-containing protein	NA	NA	NA	NA
WP_000255769.1\|744174_745209_+	heat-inducible transcriptional repressor HrcA	NA	NA	NA	NA
WP_000046031.1\|745235_745760_+	nucleotide exchange factor GrpE	NA	NA	NA	NA
WP_000034662.1\|746239_748063_+	molecular chaperone DnaK	A0A0N9QXN8	Chrysochromulina_ericina_virus	1.3e-133	47.2
WP_000115730.1\|748075_748429_+	hypothetical protein	NA	NA	NA	NA
WP_001066299.1\|748633_749770_+	molecular chaperone DnaJ	E3T4P7	Cafeteria_roenbergensis_virus	1.2e-23	31.0
WP_001808905.1\|750091_750286_-	hypothetical protein	NA	NA	NA	NA
WP_000777760.1\|750447_750735_-	hypothetical protein	NA	NA	NA	NA
WP_001278301.1\|750744_751155_-	HIT family protein	B5LJ12	Mycobacterium_phage	3.4e-05	31.6
WP_000889923.1\|751222_751954_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	9.0e-25	28.6
WP_000653752.1\|751950_753000_+	ABC transporter permease	NA	NA	NA	NA
WP_000132575.1\|753167_753497_-	hypothetical protein	NA	NA	NA	NA
WP_000682122.1\|753772_754111_+	response regulator transcription factor	NA	NA	NA	NA
WP_001219126.1\|754115_754853_+	response regulator transcription factor	NA	NA	NA	NA
WP_000275284.1\|754865_756206_+	sensor histidine kinase	NA	NA	NA	NA
WP_001821303.1\|756445_757792_-\|transposase	IS1380-like element ISSpn5 family transposase	A0A1X9I6F6	Streptococcus_phage	4.5e-78	40.0
WP_000358814.1\|757958_758114_-	quorum-sensing system pheromone BlpC	NA	NA	NA	NA
WP_001069099.1\|758170_759532_-\|bacteriocin	bacteriocin secretion accessory protein	NA	NA	NA	NA
WP_001093269.1\|761075_761324_+\|bacteriocin	Blp family class II bacteriocin	NA	NA	NA	NA
WP_000483697.1\|761339_761549_+\|bacteriocin	Blp family class II bacteriocin	NA	NA	NA	NA
WP_000497530.1\|762750_763326_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA

DBSCAN-SWA_8

993637 : 1000643

Streptococcus_phage(42.86%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000405832.1\|993637_994132_+	GNAT family N-acetyltransferase	M1PSC3	Streptococcus_phage	1.9e-42	52.1
WP_001170347.1\|994131_994662_+	methylated-DNA--[protein]-cysteine S-methyltransferase	M1PFU9	Streptococcus_phage	1.4e-46	54.3
WP_000889093.1\|994655_995012_+	arsenate reductase family protein	M1PLC0	Streptococcus_phage	1.2e-33	57.3
WP_001103449.1\|995169_995970_+	amino acid ABC transporter permease	NA	NA	NA	NA
WP_000590990.1\|995969_996713_+	amino acid ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	2.8e-29	41.0
WP_000926600.1\|996790_997015_+	DUF4059 family protein	NA	NA	NA	NA
WP_000272311.1\|997080_997992_+	thioredoxin-disulfide reductase	G3MA85	Bacillus_virus	2.9e-89	51.5
WP_000855734.1\|998029_998758_-	23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB	NA	NA	NA	NA
WP_001272941.1\|998802_999414_-	peptide deformylase	E3SLL2	Synechococcus_phage	4.9e-16	42.4
WP_000930003.1\|999926_1000643_+	CapA family protein	A0A0N9SJ77	Staphylococcus_phage	2.1e-26	30.9

DBSCAN-SWA_9

1114336 : 1177410

Indivirus(15.79%)

transposase,holin,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000895725.1\|1114336_1115236_+\|protease	zinc metalloprotease HtpX	NA	NA	NA	NA
WP_001814694.1\|1115279_1116806_-	ABC-F family ATP-binding cassette domain-containing protein	F2Y2R6	Organic_Lake_phycodnavirus	1.3e-09	31.9
WP_000773235.1\|1117564_1118107_+	DUF177 domain-containing protein	NA	NA	NA	NA
WP_000244451.1\|1118106_1118736_+	endonuclease III	NA	NA	NA	NA
WP_000850024.1\|1118946_1119468_+	bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR	NA	NA	NA	NA
WP_001293845.1\|1119486_1120410_+	aspartate carbamoyltransferase catalytic subunit	M1HGA5	Paramecium_bursaria_Chlorella_virus	8.7e-25	31.7
WP_000166701.1\|1120459_1121539_+	glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit	R4TGJ8	Halovirus	6.3e-59	35.9
WP_001126406.1\|1121851_1125028_+	carbamoyl-phosphate synthase large subunit	NA	NA	NA	NA
WP_001199645.1\|1125302_1126112_-\|holin	phosphorylcholine transferase LicD	A0A1V0SD50	Indivirus	4.5e-09	30.3
WP_000811992.1\|1126113_1126917_-\|holin	phosphorylcholine transferase LicD	A0A1V0SD50	Indivirus	5.3e-10	27.1
WP_000835917.1\|1126926_1128414_-	type IV teichoic acid flippase TacF	NA	NA	NA	NA
WP_000638502.1\|1128749_1129457_+	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	NA	NA	NA	NA
WP_000609885.1\|1129461_1130484_+	alcohol dehydrogenase catalytic domain-containing protein	NA	NA	NA	NA
WP_000411215.1\|1130500_1131370_+\|holin	choline kinase LicA	NA	NA	NA	NA
WP_000837618.1\|1131359_1132238_+	DMT family transporter	NA	NA	NA	NA
WP_000643970.1\|1132249_1132939_+	NTP transferase domain-containing protein	A0A127AW70	Bacillus_phage	3.4e-05	45.0
WP_000705301.1\|1133034_1133883_+	DNA-protecting protein DprA	S6BFL3	Thermus_phage	1.2e-33	39.1
WP_001812883.1\|1134764_1135808_+	TIGR00341 family protein	NA	NA	NA	NA
WP_000179644.1\|1135974_1138062_+	type I DNA topoisomerase	A0A1V0SCS0	Indivirus	1.0e-105	37.6
WP_001237223.1\|1138167_1138527_+	YbaN family protein	NA	NA	NA	NA
WP_000638786.1\|1138619_1139252_+	copper homeostasis protein CutC	NA	NA	NA	NA
WP_000461600.1\|1139295_1139952_+	MmcQ/YjbR family DNA-binding protein	NA	NA	NA	NA
WP_001010953.1\|1139970_1140603_+	2-isopropylmalate synthase	NA	NA	NA	NA
WP_000225489.1\|1140630_1141065_+	DNA topoisomerase I	NA	NA	NA	NA
WP_001074730.1\|1141076_1142114_+	3-isopropylmalate dehydrogenase	NA	NA	NA	NA
WP_000762426.1\|1142110_1142380_+	DUF1294 domain-containing protein	NA	NA	NA	NA
WP_000929149.1\|1142383_1142743_+	3-isopropylmalate dehydratase small subunit	NA	NA	NA	NA
WP_001042415.1\|1143693_1145625_+	McrB family protein	K4I1H4	Acidithiobacillus_phage	1.8e-16	33.7
WP_001816429.1\|1145611_1146928_+	McrC family protein	NA	NA	NA	NA
WP_000931158.1\|1147102_1148089_+	GMP reductase	G3MBI2	Bacillus_virus	1.4e-137	72.2
WP_000661503.1\|1148406_1149105_+	ribonuclease III	J2YAN1	Acanthamoeba_polyphaga_lentillevirus	1.1e-24	33.3
WP_000280942.1\|1149095_1152635_+	chromosome segregation protein SMC	NA	NA	NA	NA
WP_000153016.1\|1152631_1153426_+	Cof-type HAD-IIB family hydrolase	NA	NA	NA	NA
WP_000763457.1\|1153425_1154244_+	Cof-type HAD-IIB family hydrolase	NA	NA	NA	NA
WP_000522312.1\|1154247_1155537_+	signal recognition particle-docking protein FtsY	NA	NA	NA	NA
WP_000096139.1\|1155580_1157068_-	glucose-6-phosphate dehydrogenase	H6WFS4	Cyanophage	4.9e-70	33.0
WP_001096313.1\|1157216_1157957_-	amino acid ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	2.0e-32	40.1
WP_000726258.1\|1157956_1160122_-	ABC transporter substrate-binding protein/permease	NA	NA	NA	NA
WP_000792112.1\|1160291_1161245_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_000610410.1\|1161321_1163310_+	excinuclease ABC subunit B	NA	NA	NA	NA
WP_000639833.1\|1163319_1163883_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_000237188.1\|1163848_1164337_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_000091545.1\|1164409_1164877_+	8-oxo-dGTP diphosphatase	NA	NA	NA	NA
WP_000159178.1\|1164873_1165389_-	transcription repressor NadR	NA	NA	NA	NA
WP_001097402.1\|1165400_1165928_-	ECF transporter S component	NA	NA	NA	NA
WP_000747408.1\|1166223_1166787_-	ECF transporter S component	NA	NA	NA	NA
WP_001284130.1\|1166770_1167322_-	phosphopantothenoylcysteine decarboxylase	A0A068EHP1	Penguinpox_virus	5.2e-25	37.6
WP_000699489.1\|1167333_1168023_-	phosphopantothenate--cysteine ligase	NA	NA	NA	NA
WP_000845287.1\|1168252_1169923_+	formate--tetrahydrofolate ligase	NA	NA	NA	NA
WP_000886147.1\|1170251_1171427_+	A/G-specific adenine glycosylase	NA	NA	NA	NA
WP_000722076.1\|1171481_1172186_+	response regulator transcription factor	W8CYM9	Bacillus_phage	2.8e-39	39.8
WP_000886210.1\|1172178_1173528_+	cell wall metabolism sensor histidine kinase VicK	W8CYF6	Bacillus_phage	1.8e-34	34.6
WP_001289493.1\|1173529_1174339_+	MBL fold metallo-hydrolase	A0A0C5AFC1	Paenibacillus_phage	1.8e-34	39.0
WP_000208080.1\|1174429_1174672_+	hypothetical protein	NA	NA	NA	NA
WP_001812387.1\|1174673_1174928_+	type II toxin-antitoxin system RelE/ParE family toxin	NA	NA	NA	NA
WP_000731129.1\|1174974_1175748_+	ion transporter	A0A1B0Y2S3	Lactobacillus_phage	8.9e-23	48.6
WP_001814919.1\|1176063_1177410_-\|transposase	IS1380-like element ISSpn5 family transposase	A0A1X9I6F6	Streptococcus_phage	4.5e-78	40.0

DBSCAN-SWA_10

1422020 : 1475335

Streptococcus_phage(44.44%)

holin,protease,tRNA,bacteriocin,transposase,integrase

attL 1473824:1473883|attR 1476229:1476771

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000083731.1\|1422020_1423355_-\|tRNA	methylenetetrahydrofolate--tRNA-(uracil(54)- C(5))-methyltransferase (FADH(2)-oxidizing) TrmFO	NA	NA	NA	NA
WP_001166874.1\|1423541_1424420_-	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	1.7e-115	75.7
WP_000358228.1\|1424422_1424740_-	DNA replication initiation control protein YabA	M1PFV3	Streptococcus_phage	2.9e-28	60.0
WP_000806706.1\|1424779_1425670_-	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	1.4e-72	51.4
WP_000033363.1\|1425666_1426305_-	dTMP kinase	M1PSC7	Streptococcus_phage	2.2e-75	67.6
WP_000689706.1\|1426524_1427322_-	pyrroline-5-carboxylate reductase	A0A1X9I6T5	Streptococcus_phage	8.0e-59	50.2
WP_000254684.1\|1427325_1428588_-	glutamate-5-semialdehyde dehydrogenase	A0A1X9I5D4	Streptococcus_phage	4.2e-139	64.3
WP_001844793.1\|1428597_1429728_-	glutamate 5-kinase	A0A1X9I5D0	Streptococcus_phage	1.1e-114	58.4
WP_000728257.1\|1429807_1431691_-\|holin	phosphorylcholine esterase CbpE	Q332B9	Clostridium_botulinum_C_phage	9.5e-10	23.7
WP_000403195.1\|1431693_1432581_-	RluA family pseudouridine synthase	A0A2H4UV25	Bodo_saltans_virus	1.3e-09	28.0
WP_000745389.1\|1432570_1433032_-	signal peptidase II	NA	NA	NA	NA
WP_001025704.1\|1433028_1433937_-	LysR family transcriptional regulator	A0A2P0ZL89	Lactobacillus_phage	3.1e-06	27.7
WP_001809535.1\|1433929_1434127_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_000745372.1\|1434178_1434850_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_000602451.1\|1434903_1435125_-\|bacteriocin	SP_0924 family bacteriocin-like peptide	NA	NA	NA	NA
WP_000593571.1\|1435396_1436206_+	Cof-type HAD-IIB family hydrolase	NA	NA	NA	NA
WP_001246755.1\|1436386_1437262_-	N-carbamoylputrescine amidase	M1H5W0	Paramecium_bursaria_Chlorella_virus	1.1e-77	50.0
WP_000969458.1\|1437271_1438357_-	agmatine deiminase	M1HES8	Acanthocystis_turfacea_Chlorella_virus	2.8e-91	48.1
WP_000764377.1\|1438353_1439481_-	carboxynorspermidine decarboxylase	NA	NA	NA	NA
WP_000088782.1\|1439480_1440740_-	saccharopine dehydrogenase family protein	NA	NA	NA	NA
WP_000366713.1\|1440736_1441597_-	polyamine aminopropyltransferase	NA	NA	NA	NA
WP_001270407.1\|1441627_1441765_-	hypothetical protein	NA	NA	NA	NA
WP_000661006.1\|1442532_1444008_-	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_001153814.1\|1444714_1445590_+\|transposase	IS30 family transposase	H7BWC8	unidentified_phage	8.0e-28	31.3
WP_029645384.1\|1445585_1446164_+	VIT1/CCC1 transporter family protein	NA	NA	NA	NA
WP_000489404.1\|1446206_1448195_-	ABC transporter permease	NA	NA	NA	NA
WP_000173358.1\|1448196_1448955_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	7.7e-27	36.3
WP_000680766.1\|1449382_1449574_+	hypothetical protein	NA	NA	NA	NA
WP_001085044.1\|1449927_1450200_-	PspC domain-containing protein	NA	NA	NA	NA
WP_000778595.1\|1450258_1450708_-	SprT family protein	NA	NA	NA	NA
WP_000359141.1\|1450694_1452824_-	RNA-binding transcriptional accessory protein	NA	NA	NA	NA
WP_000123613.1\|1453235_1454141_+	permease	NA	NA	NA	NA
WP_000617843.1\|1454137_1454953_+	TIGR03943 family protein	NA	NA	NA	NA
WP_000759775.1\|1455082_1455799_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_000749599.1\|1456747_1457620_-	DUF4300 family protein	NA	NA	NA	NA
WP_001821303.1\|1459131_1460478_+\|transposase	IS1380-like element ISSpn5 family transposase	A0A1X9I6F6	Streptococcus_phage	4.5e-78	40.0
WP_001042807.1\|1460980_1462486_-	pyruvate kinase	NA	NA	NA	NA
WP_000820836.1\|1462544_1463552_-	6-phosphofructokinase	NA	NA	NA	NA
WP_000561516.1\|1463634_1466736_-	DNA polymerase III subunit alpha	A0A291AWR1	Streptomyces_phage	6.8e-114	32.8
WP_001212037.1\|1467082_1469356_+	Xaa-Pro dipeptidyl-peptidase	NA	NA	NA	NA
WP_001042996.1\|1469372_1469843_+	arginine repressor	NA	NA	NA	NA
WP_000692989.1\|1469959_1470115_-	hypothetical protein	NA	NA	NA	NA
WP_000526343.1\|1470385_1473736_-	DEAD/DEAH box helicase family protein	A0A2H4P9W3	Gordonia_phage	1.4e-11	24.8
WP_000466655.1\|1473765_1474347_-	restriction endonuclease subunit S	NA	NA	NA	NA
1473824:1473883	attL	NA	NA	NA	NA
WP_000444456.1\|1474369_1475335_-\|integrase	tyrosine-type recombinase/integrase	A0A2H4JAA2	uncultured_Caudovirales_phage	1.8e-33	29.6
WP_000444456.1\|1474369_1475335_-\|integrase	tyrosine-type recombinase/integrase	A0A2H4JAA2	uncultured_Caudovirales_phage	1.8e-33	29.6
1476229:1476771	attR	NA	NA	NA	NA

DBSCAN-SWA_11

1537658 : 1601740

Streptococcus_phage(20.0%)

transposase,tRNA,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000882517.1\|1537658_1539917_+\|protease	ATP-dependent Clp protease ATP-binding subunit	K4FB40	Cronobacter_phage	4.6e-128	40.4
WP_000767193.1\|1541689_1541989_+	DUF1827 family protein	NA	NA	NA	NA
WP_000064821.1\|1545761_1547489_-	septation ring formation regulator EzrA	NA	NA	NA	NA
WP_000134044.1\|1547570_1549517_-	DNA topoisomerase (ATP-hydrolyzing) subunit B	G3M9Z3	Bacillus_virus	6.1e-145	45.3
WP_001809365.1\|1549531_1550095_-	HAD family hydrolase	NA	NA	NA	NA
WP_000241397.1\|1550179_1550734_-	DJ-1/PfpI family protein	A0A0N7KVR4	Yellowstone_lake_phycodnavirus	6.4e-07	27.2
WP_000830659.1\|1550744_1551968_-	FtsW/RodA/SpoVE family cell cycle protein	NA	NA	NA	NA
WP_000848713.1\|1552004_1554455_-	bifunctional DnaQ family exonuclease/ATP-dependent helicase	A0A1X9I5C8	Streptococcus_phage	8.4e-200	47.5
WP_000411851.1\|1554654_1555584_-	U32 family peptidase	NA	NA	NA	NA
WP_001145226.1\|1555723_1556011_+	DUF3270 domain-containing protein	NA	NA	NA	NA
WP_000491790.1\|1556044_1557379_-	two-component system sensor histidine kinase CiaH	Q8QNA2	Ectocarpus_siliculosus_virus	1.2e-06	34.0
WP_000590640.1\|1557368_1558043_-	two-component system response regulator CiaR	W8CYM9	Bacillus_phage	3.1e-27	33.6
WP_001149107.1\|1558151_1560698_-	M1 family metallopeptidase	A0A0P0IY26	Acinetobacter_phage	7.4e-74	27.2
WP_000188827.1\|1560820_1561261_-	ASCH domain-containing protein	NA	NA	NA	NA
WP_001245817.1\|1561235_1562105_-	hypothetical protein	NA	NA	NA	NA
WP_000403351.1\|1562082_1562583_-	NUDIX hydrolase	NA	NA	NA	NA
WP_000167112.1\|1562593_1563292_-	3-oxoacyl-ACP reductase	A0A0K0KVL6	Prochlorococcus_phage	2.8e-07	30.9
WP_001808490.1\|1563284_1563551_-	DUF2829 domain-containing protein	NA	NA	NA	NA
WP_001269466.1\|1563616_1564543_-	aldo/keto reductase family oxidoreductase	NA	NA	NA	NA
WP_000738401.1\|1564617_1565433_-	membrane protein	NA	NA	NA	NA
WP_000665420.1\|1565436_1565757_-	PadR family transcriptional regulator	NA	NA	NA	NA
WP_001291375.1\|1566312_1568310_-\|tRNA	methionine--tRNA ligase	A0A1V0SEZ7	Hokovirus	4.7e-84	30.8
WP_001180425.1\|1568433_1569693_-	ABC transporter permease	NA	NA	NA	NA
WP_000811482.1\|1569694_1570396_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	4.0e-38	43.9
WP_000728653.1\|1570379_1571579_-	efflux RND transporter periplasmic adaptor subunit	NA	NA	NA	NA
WP_001209571.1\|1571864_1573211_+	glutathione-disulfide reductase	NA	NA	NA	NA
WP_000709032.1\|1573407_1573944_+	biotin transporter BioY	NA	NA	NA	NA
WP_000807422.1\|1574149_1574365_-	hypothetical protein	NA	NA	NA	NA
WP_001216108.1\|1574462_1574783_+	hypothetical protein	NA	NA	NA	NA
WP_001196049.1\|1574812_1575151_-	hypothetical protein	NA	NA	NA	NA
WP_000686921.1\|1575162_1575882_-\|tRNA	tRNA (guanosine(37)-N1)-methyltransferase TrmD	NA	NA	NA	NA
WP_001105899.1\|1575871_1576390_-	ribosome maturation factor RimM	NA	NA	NA	NA
WP_000819181.1\|1576420_1577209_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_001816270.1\|1577755_1579102_+\|transposase	IS1380-like element ISSpn5 family transposase	A0A1X9I6F6	Streptococcus_phage	3.4e-78	40.0
WP_001040724.1\|1579562_1580759_-	elongation factor Tu	A0A076FFS6	Aureococcus_anophage	7.3e-32	29.6
WP_000348122.1\|1581669_1582539_-	aquaporin family protein	NA	NA	NA	NA
WP_000248982.1\|1582761_1583283_-	LPXTG cell wall anchor domain-containing protein	NA	NA	NA	NA
WP_001821371.1\|1583254_1584346_-	MucBP domain-containing protein	NA	NA	NA	NA
WP_000935666.1\|1584456_1584711_-	hypothetical protein	NA	NA	NA	NA
WP_000200308.1\|1585050_1585584_-\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_001811210.1\|1585570_1585786_-\|transposase	transposase	NA	NA	NA	NA
WP_001811209.1\|1585752_1585896_-\|transposase	transposase	NA	NA	NA	NA
WP_000121714.1\|1586129_1587848_+	phospho-sugar mutase	A0A1X9I671	Streptococcus_phage	3.4e-272	83.2
WP_000434649.1\|1587958_1588306_+	thioredoxin	NA	NA	NA	NA
WP_000759189.1\|1588584_1589421_-	amino acid ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_000891765.1\|1589433_1590063_-	amino acid ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	6.8e-29	36.7
WP_000120830.1\|1590072_1590714_-	amino acid ABC transporter permease	NA	NA	NA	NA
WP_001065958.1\|1590859_1592089_-	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_000435455.1\|1592078_1593245_-	AI-2E family transporter	NA	NA	NA	NA
WP_000665621.1\|1593388_1594402_+	lactonase family protein	NA	NA	NA	NA
WP_000068050.1\|1594446_1594866_-	F0F1 ATP synthase subunit epsilon	NA	NA	NA	NA
WP_000094364.1\|1594876_1596283_-	F0F1 ATP synthase subunit beta	NA	NA	NA	NA
WP_000301210.1\|1596368_1597247_-	F0F1 ATP synthase subunit gamma	NA	NA	NA	NA
WP_000996639.1\|1597262_1598768_-	F0F1 ATP synthase subunit alpha	NA	NA	NA	NA
WP_000359036.1\|1598782_1599319_-	F0F1 ATP synthase subunit delta	NA	NA	NA	NA
WP_000558554.1\|1599318_1599813_-	F0F1 ATP synthase subunit B	NA	NA	NA	NA
WP_000392851.1\|1599826_1600543_-	F0F1 ATP synthase subunit A	NA	NA	NA	NA
WP_001054562.1\|1600577_1600778_-	F0F1 ATP synthase subunit C	NA	NA	NA	NA
WP_001153892.1\|1600852_1601740_-\|transposase	IS30 family transposase	H7BWC8	unidentified_phage	6.2e-28	31.3

DBSCAN-SWA_12

1656627 : 1663386

Streptococcus_phage(50.0%)

protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000081004.1\|1656627_1657596_+	NAD(P)/FAD-dependent oxidoreductase	Q9JRK7	Streptococcus_phage	1.8e-65	99.2
WP_000011306.1\|1657629_1658541_-	DNA-binding protein WhiA	Q7AWZ3	Streptococcus_phage	1.5e-154	99.7
WP_001231086.1\|1658537_1659515_-	YvcK family protein	A1IMD5	Streptococcus_phage	1.2e-184	100.0
WP_000163033.1\|1659511_1660402_-	RNase adapter RapZ	A0A0R8VB27	Thermobifida_phage	3.9e-06	29.8
WP_001140412.1\|1660453_1660834_-	RidA family protein	NA	NA	NA	NA
WP_000422599.1\|1660844_1661432_-	YihA family ribosome biogenesis GTP-binding protein	NA	NA	NA	NA
WP_001814787.1\|1661440_1662673_-\|protease	ATP-dependent Clp protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	4.2e-131	58.7
WP_000442260.1\|1662709_1662880_-	hypothetical protein	NA	NA	NA	NA
WP_000162475.1\|1662879_1663386_-	dihydrofolate reductase	A0A1B2IAU3	Erwinia_phage	7.4e-18	31.1

DBSCAN-SWA_13

1916453 : 1923868

uncultured_Mediterranean_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001814725.1\|1916453_1917173_+	UDP-glucose 4-epimerase GalE	A0A2K9L1R4	Tupanvirus	4.7e-34	36.2
WP_001838026.1\|1917169_1917364_+	hypothetical protein	NA	NA	NA	NA
WP_000778475.1\|1917660_1918620_+	ABC transporter permease	A0A2H4IY97	uncultured_Caudovirales_phage	2.4e-57	40.8
WP_001193665.1\|1918609_1919566_+	iron chelate uptake ABC transporter family permease subunit	NA	NA	NA	NA
WP_000764303.1\|1919562_1920315_+	ATP-binding cassette domain-containing protein	W6JKT0	Anomala_cuprea_entomopoxvirus	5.6e-14	28.1
WP_000858251.1\|1920410_1921376_+	siderophore ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_000821615.1\|1921600_1921843_-	membrane protein insertion efficiency factor YidD	A0A2H4PQM5	Staphylococcus_phage	7.8e-18	59.4
WP_001222228.1\|1921842_1922565_-	rRNA pseudouridine synthase	NA	NA	NA	NA
WP_000105310.1\|1922551_1923121_-	segregation/condensation protein B	A0A1B1IVT7	uncultured_Mediterranean_phage	5.0e-15	34.9
WP_000351913.1\|1923139_1923868_-	segregation/condensation protein A	A0A1B1IVW1	uncultured_Mediterranean_phage	4.1e-09	22.3

DBSCAN-SWA_14

2005333 : 2034754

Streptococcus_phage(89.29%)

bacteriocin,transposase,integrase

attL 1997034:1997049|attR 2037298:2037313

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1997034:1997049	attL	NA	NA	NA	NA
WP_000420682.1\|2005333_2005648_+	YdcP family protein	A0A1S5SF38	Streptococcus_phage	5.2e-54	100.0
WP_000985015.1\|2005663_2006050_+	YdcP family protein	A0A1S5SF96	Streptococcus_phage	3.0e-64	100.0
WP_000813494.1\|2006078_2007464_+	DNA translocase FtsK	A0A1S5SFB5	Streptococcus_phage	1.9e-265	99.8
WP_000879507.1\|2007466_2007619_+	hypothetical protein	NA	NA	NA	NA
WP_001814870.1\|2007641_2008904_+	replication initiation factor domain-containing protein	A0A1S5SEX3	Streptococcus_phage	3.1e-230	99.0
WP_029645760.1\|2008848_2009061_+	peptide-binding protein	A0A1X9I6D5	Streptococcus_phage	1.5e-12	78.7
WP_001814874.1\|2009109_2009193_+	23S rRNA methyltransferase attenuation leader peptide	NA	NA	NA	NA
WP_001038795.1\|2009317_2010055_+	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B)	E4ZFQ0	Streptococcus_phage	3.1e-134	99.2
WP_000019067.1\|2010311_2011559_-\|transposase	ISL3 family transposase	Q6V7R1	Burkholderia_virus	3.9e-12	23.9
WP_001009056.1\|2011738_2011960_+	hypothetical protein	A0A1S5SEY0	Streptococcus_phage	4.3e-31	100.0
WP_000342539.1\|2012076_2012574_+	antirestriction protein ArdA	A0A1S5SF25	Streptococcus_phage	1.7e-91	100.0
WP_000506270.1\|2012548_2013055_+	conjugal transfer protein	A0A1S5SEX7	Streptococcus_phage	8.6e-91	100.0
WP_000331160.1\|2013038_2015486_+	ATP-binding protein	A0A1S5SF64	Streptococcus_phage	0.0e+00	100.0
WP_001814875.1\|2015488_2017666_+	membrane protein	A0A1S5SF30	Streptococcus_phage	0.0e+00	98.6
WP_000769868.1\|2017662_2018664_+	bifunctional lysozyme/C40 family peptidase	A0A1S5SEZ8	Streptococcus_phage	5.0e-191	100.0
WP_001224318.1\|2018660_2019593_+	conjugal transfer protein	A0A1S5SF22	Streptococcus_phage	3.1e-171	99.4
WP_001814923.1\|2019837_2019954_+	tetracycline resistance determinant leader peptide	NA	NA	NA	NA
WP_000691729.1\|2019969_2021889_+	tetracycline resistance ribosomal protection protein Tet(M)	A0A1S5SF82	Streptococcus_phage	0.0e+00	97.3
WP_001813542.1\|2022252_2022498_+	hypothetical protein	A0A1B0RXA7	Streptococcus_phage	2.6e-37	98.8
WP_000806926.1\|2022494_2022830_+	hypothetical protein	NA	NA	NA	NA
WP_000567222.1\|2022842_2023211_+	hypothetical protein	A0A1B0RXA8	Streptococcus_phage	1.1e-58	97.5
WP_001072467.1\|2023197_2023497_+	hypothetical protein	A0A1B0RX98	Streptococcus_phage	1.8e-48	96.0
WP_000420313.1\|2023614_2025078_-	ABC-F type ribosomal protection protein Msr(D)	A0A1B0RXA0	Streptococcus_phage	3.7e-251	97.3
WP_000417519.1\|2025197_2026415_-	macrolide efflux MFS transporter Mef(A)	A0A2K5B2B5	Erysipelothrix_phage	5.1e-198	90.6
WP_000873143.1\|2026800_2026971_-	hypothetical protein	A0A1X9I6E4	Streptococcus_phage	3.7e-22	98.2
WP_001860868.1\|2027492_2027684_+	cysteine-rich KTR domain-containing protein	D0R0F6	Streptococcus_phage	5.4e-14	69.4
WP_001227347.1\|2027743_2028097_-	helix-turn-helix domain-containing protein	A0A1S5SFA6	Streptococcus_phage	1.3e-58	100.0
WP_000804885.1\|2028601_2029024_+	sigma-70 family RNA polymerase sigma factor	A0A1S5SEW0	Streptococcus_phage	2.5e-72	100.0
WP_000857133.1\|2029020_2029251_+	helix-turn-helix domain-containing protein	A0A1S5SEX1	Streptococcus_phage	2.7e-36	100.0
WP_000814511.1\|2029711_2029915_+	excisionase	A0A1S5SF07	Streptococcus_phage	4.0e-31	100.0
WP_001291561.1\|2029996_2031214_+\|integrase	tyrosine-type recombinase/integrase	A0A1S5SEW7	Streptococcus_phage	3.7e-233	100.0
WP_000732395.1\|2032104_2034120_+\|bacteriocin	bacteriocin-associated integral membrane family protein	NA	NA	NA	NA
WP_000571425.1\|2034121_2034754_+	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	2.8e-22	32.9
2037298:2037313	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_014251

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CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection