CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_017592	Streptococcus pneumoniae OXC141, complete genome	1 crisprs	DEDDh,cas3,DinG,RT	0	0	9	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_017592_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017592_1

128351-128446

Orphan

Consensus_repeat	Method
AATGTGTAAGATTTTTATATATAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017592_1

>merge|NC_017592|1|128351-128446|CRISPRCasFinder
AATGTGTAAGATTTTTATATATAATTTTTCTACACATACATTGTACATCTAAAAGAAAGCCCTGTCAAGAGAAATGTGTAAAATTTTTATATATAA

>NC_017592|1|1|128351-128446|CRISPRCasFinder
AATGTGTAAGATTTTTATATATAA	TTTTTCTACACATACATTGTACATCTAAAAGAAAGCCCTGTCAAGAGA
AATGTGTAAAATTTTTATATATAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_017592.1\|WP_000096195.1\|129695_130853_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133016
NC_017592.1\|WP_000714576.1\|119400_120330_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226666
NC_017592.1\|WP_000808448.1\|125395_126460_-\|membrane-protein	unknown	unknown	gnl\|CDD\|370966
NC_017592.1\|WP_000200899.1\|133094_133727_-\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|319798
NC_017592.1\|WP_001030031.1\|123097_124084_+\|rhodanese-related-sulfurtransferase	unknown	unknown	gnl\|CDD\|234663
NC_017592.1\|WP_000058099.1\|118860_119082_+\|hypothetical-protein	unknown	unknown	unknown
NC_017592.1\|WP_001075102.1\|120343_121267_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_017592.1\|WP_000800407.1\|121350_122826_+\|DUF3502-domain-containing-protein	unknown	unknown	gnl\|CDD\|378792
NC_017592.1\|WP_001108795.1\|137367_137955_+\|hypothetical-protein	unknown	unknown	unknown
NC_017592.1\|WP_000836442.1\|135542_136130_+\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|212030
NC_017592.1\|WP_000693202.1\|132769_133045_-\|hypothetical-protein	unknown	unknown	unknown
NC_017592.1\|WP_000198688.1\|127426_128020_-\|DUF1700-domain-containing-protein	unknown	unknown	gnl\|CDD\|227053
NC_017592.1\|WP_000500038.1\|133748_134621_-\|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-alpha	unknown	unknown	gnl\|CDD\|129801
NC_017592.1\|WP_001233685.1\|126522_127434_-\|DUF4097-domain-containing-protein	unknown	unknown	gnl\|CDD\|372574
NC_017592.1\|WP_000744889.1\|128471_129638_-\|CynX/NimT-family-MFS-transporter	unknown	unknown	gnl\|CDD\|225365
NC_017592.1\|WP_000838912.1\|134629_135301_-\|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-beta	unknown	unknown	gnl\|CDD\|224674
NC_017592.1\|WP_000273863.1\|128006_128333_-\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NC_017592.1\|WP_001268179.1\|136181_137045_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NC_017592.1\|WP_001140364.1\|124358_125219_+\|DUF4299-domain-containing-protein	unknown	unknown	gnl\|CDD\|339103
NC_017592.1\|WP_001035700.1\|130894_132745_+\|polysaccharide-biosynthesis-protein	unknown	unknown	gnl\|CDD\|224011

Protein	Function_ID	Function_description	E-value
NC_017592.1\|WP_000096195.1\|129695_130853_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|133016	cd02525, Succinoglycan_BP_ExoA, ExoA is involved in the biosynthesis of succinoglycan. Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.	3.11332e-108
NC_017592.1\|WP_000714576.1\|119400_120330_+\|sugar-ABC-transporter-permease	gnl\|CDD\|226666	COG4209, LplB, ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism].	1.16109e-142
NC_017592.1\|WP_000808448.1\|125395_126460_-\|membrane-protein	gnl\|CDD\|370966	pfam10310, DUF5427, Family of unknown function (DUF5427). This is a domain of unknown function. Family members found in Saccharomyces cerevisiae, are synthetic lethal with genes involved in maintenance of telomere capping. However, experimental evidence is yet to verify the exact function of family members and the domain.	5.6483e-05
NC_017592.1\|WP_000200899.1\|133094_133727_-\|HAD-family-hydrolase	gnl\|CDD\|319798	cd04302, HAD_5NT, haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to the Pseudomonas aeruginosa PA0065. 5'-nucleotidases dephosphorylate nucleoside 5'-monophosphates to nucleosides and inorganic phosphate. Purified Pseudomonas aeruginosa PA0065 displayed high activity toward 5'-UMP and 5'-IMP, significant activity against 5'-XMP and 5'-TMP, and low activity against 5'-CMP. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	4.47172e-97
NC_017592.1\|WP_001030031.1\|123097_124084_+\|rhodanese-related-sulfurtransferase	gnl\|CDD\|234663	PRK00142, PRK00142, rhodanese-related sulfurtransferase.	0
NC_017592.1\|WP_000838912.1\|134629_135301_-\|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-beta	gnl\|CDD\|224674	COG1760, SdaA, L-serine deaminase [Amino acid transport and metabolism].	1.1908e-89
NC_017592.1\|WP_001075102.1\|120343_121267_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	5.04007e-69
NC_017592.1\|WP_000800407.1\|121350_122826_+\|DUF3502-domain-containing-protein	gnl\|CDD\|378792	pfam12010, DUF3502, Domain of unknown function (DUF3502). This presumed domain is functionally uncharacterized. This domain is found in bacteria. This domain is about 140 amino acids in length. This domain is found associated with pfam01547.	4.24398e-44
NC_017592.1\|WP_000836442.1\|135542_136130_+\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|212030	cd00118, LysM, Lysin Motif is a small domain involved in binding peptidoglycan. LysM, a small globular domain with approximately 40 amino acids, is a widespread protein module involved in binding peptidoglycan in bacteria and chitin in eukaryotes. The domain was originally identified in enzymes that degrade bacterial cell walls, but proteins involved in many other biological functions also contain this domain. It has been reported that the LysM domain functions as a signal for specific plant-bacteria recognition in bacterial pathogenesis. Many of these enzymes are modular and are composed of catalytic units linked to one or several repeats of LysM domains. LysM domains are found in bacteria and eukaryotes.	5.22512e-13
NC_017592.1\|WP_000198688.1\|127426_128020_-\|DUF1700-domain-containing-protein	gnl\|CDD\|227053	COG4709, COG4709, Predicted membrane protein [Function unknown].	1.19707e-63
NC_017592.1\|WP_000500038.1\|133748_134621_-\|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-alpha	gnl\|CDD\|129801	TIGR00718, Probable_L-serine_dehydratase_alpha_chain, L-serine dehydratase, iron-sulfur-dependent, alpha subunit. This enzyme is also called serine deaminase. L-serine dehydratase converts serine into pyruvate in the gluconeogenesis pathway from serine. This model describes the alpha chain of an iron-sulfur-dependent L-serine dehydratase, found in Bacillus subtilis. A fairly deep split in a UPGMA tree separates members of this family of alpha chains from the homologous region of single chain forms such as found in Escherichia coli. This family of enzymes is not homologous to the pyridoxal phosphate-dependent threonine deaminases and eukaryotic serine deaminases. [Energy metabolism, Amino acids and amines, Energy metabolism, Glycolysis/gluconeogenesis].	2.65225e-106
NC_017592.1\|WP_001233685.1\|126522_127434_-\|DUF4097-domain-containing-protein	gnl\|CDD\|372574	pfam13349, DUF4097, Putative adhesin. This has a putative all-beta structure with a twenty-residue repeat with a highly conserved repeating GD, gly-asp, motif. It may form part of a bacterial adhesin.	1.5652e-38
NC_017592.1\|WP_000744889.1\|128471_129638_-\|CynX/NimT-family-MFS-transporter	gnl\|CDD\|225365	COG2807, CynX, Cyanate permease [Inorganic ion transport and metabolism].	6.17153e-126
NC_017592.1\|WP_000273863.1\|128006_128333_-\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	8.86871e-19
NC_017592.1\|WP_001268179.1\|136181_137045_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	1.6379e-10
NC_017592.1\|WP_001140364.1\|124358_125219_+\|DUF4299-domain-containing-protein	gnl\|CDD\|339103	pfam14132, DUF4299, Domain of unknown function (DUF4299). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 275 and 313 amino acids in length. There are two conserved sequence motifs: RGF and DAY. There are two completely conserved residues (P and D) that may be functionally important.	4.77123e-120
NC_017592.1\|WP_001035700.1\|130894_132745_+\|polysaccharide-biosynthesis-protein	gnl\|CDD\|224011	COG1086, COG1086, Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism].	0

>NC_017592.1|WP_000273863.1|128006_128333_-|PadR-family-transcriptional-regulator
MYFPTSSALIEFLILAVLEQGDSYGYEISQTIKLIANIKESTLYPILKKLEGNSFLTTYSREFQGRMRKYYSLTNGGIEQLLTLKDEWALYTDTINGIIEGSIRHDKN
>NC_017592.1|WP_000198688.1|127426_128020_-|DUF1700-domain-containing-protein
MTRTEYLTQLELYLKKLPEADRIEAMDYFRELFDDAGVEGEEELIASLGTPKEAAHEVLSNLLDKKINEAPAQKNNRQILHIALLALLAAPIGIPLGIAILVTLFAILVAALTVILAFFAVSILGIIGGFLFLVESFTILAQAKSAFILIFGSGLLAIGASSLVLLGISYVTRFFGLLIVRLVQFVLKKGKRGNQHA
>NC_017592.1|WP_001233685.1|126522_127434_-|DUF4097-domain-containing-protein
MRKWTKGFLIFGVVTTVIGFILLFVGIQSDGIKSLLSMSKEPIYDSRTEKLTFGKEVENLEITLHQHALTITDSFDDQIHISYHPSLSAHHDLITNQNDRTLSLTDKKLSETPFLSSGIGGILHIASSYSSRFEEVILQLPKGRTLKGINISANRGQTTIINASLENATLNTNSYILRIEGSRIKNSKLTTPNIVNIFDTVLTDSQLESTENHFHAENIQVHGKVELTAKDYLRIILNQKESQRINWDISSNYGSIFQFTREKPESRGTELSNPYKTEKTDVKDQLIARSDDNIDLISTPSRR
>NC_017592.1|WP_000808448.1|125395_126460_-|membrane-protein
MKQEWFESNDFVKTTSKNKPEEQAQEVADKAEETIADLDTPIEKNTQLEEEVSQAEVELESQQEEKIEAPEDSEARTKIEEKKASNSTEEEPDLSKETEKVTIAEESQEALPQQKATTKEPLLISKSLESPYIPYQAPKSRDKWKEQVLDFWSWLVEAIKSPTSKFETSITHSYTAFLLLILFSASSFFFSIYHIKHAYYGHIASINSRFPEQLAPLTLFSIISILVATTLFFFSFLLGSFVVRRFIHQEKDWTLDKVLQQYSQLLAIPIFLTAIASFFAFFDSLRFTALLCVISIGIILLASLHIITRPSQASETDSFYQLFLSVLVNGVIILLFFVAEVALIGDYLRILAFL
>NC_017592.1|WP_001140364.1|124358_125219_+|DUF4299-domain-containing-protein
MAKTFFIPNKQSILGEQEILNAKSILALLDGLESHSYDVVYLRQPLNRLEYIECAIVGQSQFLFKVSYADGQKAYRVDVPDLLTKTDWQIIKSFLDALLAYTGTDIEGLDGFDFEAYFQASIQAYLADPVARFTICQGIFNPIFFSRENLKSFLEVDGLAQFEARVRAVQETDAYFARVSFYQDGEGKVHGVYHLAQGVKTVLPREPFVPAAYIEQLVDKEVQWEIDLVQITGDGSKPEDYEAIARLDYAKFLEVLPLSFYHQLDANQIEVQPILDKDFKALAQEE
>NC_017592.1|WP_001030031.1|123097_124084_+|rhodanese-related-sulfurtransferase
MAKDIRVLLYYLYTPIENAEQFAADHLAFCKSIGLKGRILVADEGINGTVSGDYETTQKYMDYVHSLPGMEELWFKIDEENEQAFKKMFVRYKKEIVHLGLEDNDFDNDINPLETTGAYLSPKEFKEALLDKDTVVLDTRNDYEYDLGHFRGAIRPDIRNFRELPQWVRDNKEKFMDKRVVVYCTGGVRCEKFSGWMVREGYKDVGQLHGGIATYGKDPEVQGELWDGKMYVFDERIAVDVNHVNPTIVGKDWFDGTPCERYVNCGNPFCNRRILTSEENEDKYLRGCSHECRVHPRNRYVSKNELTQAEVIERLAAIGESLDQAATV
>NC_017592.1|WP_000800407.1|121350_122826_+|DUF3502-domain-containing-protein
MKNWKKYAFASASVVALAAGLAACGNLTGNSKKAADSGDKPVIKMYQIGDKPDNLDELLANANKIIEEKVGAKLDIQYLGWGDYGKKMSVITSSGENYDIAFADNYIVNAQKGAYADLTELYKKEGKDLYKALDPAYIKGNTVNGKIYAVPVAANVASSQNFAFNGTLLAKYGIDISGVTSYETLEPVLKQIKEKAPDVVPFAIGKVFIPSDNFDYPVANGLPFVIDLEGDTTKVVNRYEVPRFKEHLKTLHKFYEAGYIPKDVATSDTSFDLQQDTWFVREETVGPADYGNSLLSRVANKDIQIKPITNFIKKNQTTQVANFVISNNSKNKEKSMEILNLLNTNPELLNGLVYGPEGKNWEKIEGKENRVRVLDGYKGNTHMGGWNTGNNWILYINENVTDQQIENSKKELAEAKESPALGFIFNTDNVKSEISAIANTMQQFDTAINTGTVDPDKAIPELMEKLKSEGAYEKVLNEMQKQYDEFLKNKK
>NC_017592.1|WP_001075102.1|120343_121267_+|carbohydrate-ABC-transporter-permease
MAKKKIKKEKIDNVGIHSFSKKADIFFSIISGLIALSCILPFVFVIIISVTDEKSLLQYGYSFFPSQFGLDGFEFLAQFKDKILQALFISVFVTVVGTLTNVFITTTYAYAISRTTFKYRRFFTIFVLLSMLFNAGLVPGYIMVTRVLQLGDTVWALIVPMLLSPFNIILMRSFFKKTIPEAILESARIDGASEARIFFQICLPLSLPGIATITLLTALGFWNDWFNALLYIKSDNLYPLQYLLMQIQQNMDYIAKAVGLTGQLGVALPKETGRMAMVVVATLPIAILYPFFQRYFVKGLTIGGVKE
>NC_017592.1|WP_000714576.1|119400_120330_+|sugar-ABC-transporter-permease
MKKFSKTLRDNWIFLLMVLPGALWLILFFYIPVFGNVVAFKDYHMTSNGFIDSIINSKWVGLDNFRFLFSSRDAFIITRNTVLYNLGFIFLGLVVSVGIAIILSELRSKRMVKIFQTSMLFPYFLSWVIISFFTDAFLNIDKGVFNHLLESLGLKEVNFYADLGIWPYLLLFLGIWKGFGYSSVMYYATIMGIDPTYYEAATVDGASKWQRIRNVTIPQLTPLVTVLSILAVGNIFRADFGLFYQIPHNAGQLYNVTNVLDVYVFNGLTQTADIGMAAAAGLYQSVVGLILVILSNLLARRVDPNSALF
>NC_017592.1|WP_000058099.1|118860_119082_+|hypothetical-protein
MSLQIKLKKLAKELSKLLKDSNLETVDKDVLENSQEELQKAVLFLADEKGSEHTAAELIDNLKEVIAKLKANA
>NC_017592.1|WP_000744889.1|128471_129638_-|CynX/NimT-family-MFS-transporter
MKKQSLFFVPGIILIGVSLRTPFTVLPIILGNISQGLEVEVSSLGVLTSLPLLMFTFFSPFSTQLAQKIGLEHLFTYSLFFLTIGSLIRLINLPLLYLGTLMVGASVAVINVLLPSLIQANQPKKIGFLTTLYVTSMGIATALASYLAVPITQASSWKGLILLLTLLCLATFLVWLPNHHYNHRLAPQTKQKSQIKVMRNKQVWAIIIFSGFQSLIFYTVMTWLPTMSIHAGLSSHEAGLLTSILSLISIPFSMTIPSLTTSLSTRNRQLMLTLVSLAGVVGISMLFFPINNFIYWLAIHLLIGTATSALFPYLMVNFSLKTSAPEKTAQLSGLSQTGGYILAAFGPTLFGYSFDLFHSWVPSVAALLLIDILMTVALFTVDRADKIL
>NC_017592.1|WP_000096195.1|129695_130853_+|glycosyltransferase-family-2-protein
MSSKVSGFQDKNGKVLKIMIEWWKEKFRRVVVTQNVESLLVSIVISAYNEEKYLPGLIEDLKNQTYPKENIEILFINAMSTDGTTAIIQQFIKEDTEFNSIRLYNNPKKNQASGFNLGVKHSVGDLILKIDAHSKVTESFVMNNVAIIQQGEFVCGGPRPTIVEGKGKWAETLHLVEENMFGSSIANYRNSSEDRYVSSIFHGMYKREVFQKVGLVNEQLGRTEDNDIHYRIREYGYKIRYSPSILSYQYIRPTFKKMLHQKYLNGLWIGLTSHVQFKCLSLFHYVPCLFVLSLVFSLALLPITFVFITLLLGAYFLLLSLLTLLTLLKHKNGFLIVMPFLLFSIHFAYGFGTIIGLIRGFKWKKEYKRTIIYLDKISQINKNML
>NC_017592.1|WP_001035700.1|130894_132745_+|polysaccharide-biosynthesis-protein
MNKKLTDYVIDLVEILNKQQKQVFWGIFDIFSMVVSIIVSYILFYGLINPAPVDYIIYTSLAFLFYQLMIGFWGLNASISRYSKITDFMKIFFGVTASSVLSYSICYAFLPLFSIRFIILFILLSTFLILLPRITWQLIYSRRKKGSGDGEHRRTFLIGAGDGGALFMDSYQHPTSELELVGILDKDSKKKGQKLGGIPVLGSYDNLPELAKRHQIERVIVAIPSLDPSEYERILQMCNKLGVKCYKMPKVETVVQGLHQAGTGFQKIDITDLLGRQEIRLDESRLGAELTGKTILVTGAGGSIGSEICRQVSRFNPERIVLLGHGENSIYLVYHELIRKFQGIDYVPVIADIQDYDRLLQVFEQYKPAIVYHAAAHKHVPMMERNPKEAFKNNIRGTYNVAKAVDEAKVSKMVMISTDKAVNPPNVMGATKRVAELIVTGFNQRSQSTYCAVRFGNVLGSRGSVIPVFERQIAEGGPVTVTDFRMTRYFMTIPEASRLVIHAGAYAKDGEVFILDMGKPVKIYDLAKKMVLLSGHTESEIPIVEVGIRPGEKLYEELLVSTELVDNQVMDKIFVGKVNVMPLESINQKIGEFRTLSGDELKQAIIAFANQTTHIE
>NC_017592.1|WP_000693202.1|132769_133045_-|hypothetical-protein
MKIKEQTRKLAAGCSKHCFKVVNGTDEVSSKHCFEVVDGTDEVSSKHCFEVVDRTDEVSNHIYGKATLTWFEEIFEEYKSLHNKTHITKVV
>NC_017592.1|WP_000200899.1|133094_133727_-|HAD-family-hydrolase
MTSITAIFFDLDGTLVDSSIGIHNAFTYTFKELGVPSPDAKTIRGFMGPPLESSFATCLSKDQISEAVQIYRSYYKTKGIYEAQLFPQIIDLLEELSSSYPLYITTTKNTSTAQDMAKNLEIHHFFDGIYGSSPEAPHKADVIHQALQTHQLAPEQAIIIGDTKFDMLGARETGIQKLAITWGFGEQADLLNYQPDYIAHKPLEVLAYFQ
>NC_017592.1|WP_000500038.1|133748_134621_-|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-alpha
MFYSIKELVEQADLDFQGNVAELMITTEFELTGREREEVFLLMERNLEVMKASVQLGLNENKSRSGLTGGDAAKLDHYIENGKTLSDYTILSAARNAIAVNEHNAKMGLVCATPTAGSAGCLPSVLTAAIEKLDLSHEQQLDFLFAAGAFGLVIANNASISGAEGGCQAEVGSASAMSAAALTLAAGGTPYQASQAIAFVIKNMLGLICDPVAGLVEVPCVKRNAMGASFAFIAADMALAGIESKIPVDEVIDAMYQVGASMPTAFRETAEGGLATTPTGRRLQKEIFGE
>NC_017592.1|WP_000838912.1|134629_135301_-|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-beta
MKSLRFQSVFDIIGPVMIGPSSSHTAGAVRIGKIVSSIFDDTPTEVEFQLFNSFAKTYRGHGTDLALVAGILGMDTDDPEIPNSLEIAHKRGIKIVWTIQKDSNAPHPNTTKITVKNAHKTISVTGISIGGGNIQVTELNGFAVSLNMNTPTIIIVHQDIPGMIALVTEALSRYGINIAQMNVTREKAGEKAIMIIEVDSRNCDEAIEEIRKIPHLHNVNFFK
>NC_017592.1|WP_000836442.1|135542_136130_+|LysM-peptidoglycan-binding-domain-containing-protein
MKSITKKIKATLAGVAALFAVFAPSFVSAQESSTYTVKEGDTLSEIAETHNTTVEKLAENNHIDNIHLIYVDQELVIDGPVAPVATPAPATYAAPAAQDETVSAPVAETPVVSETVVSTVSGSEAEAKEWIAQKESGGSYTATNGRYIGRYQLTDSYLNGDYSAENQERVADAYVAGRYGSWTAAKNFWLNNGWY
>NC_017592.1|WP_001268179.1|136181_137045_-|helix-turn-helix-transcriptional-regulator
MRYDFGKVYKEIRESKGLTQEEVCGNVISRTSLSKIESGKATPKYENMEFLLRQINMSFEEFDYICHLYQPSQRTEIMQTYLNMTSIIGSNSLVHFFETCQDYLKTHHDLPIEEIRDMLEVVIYIRQHGAGELSDHAEQVVKKLWRKIEKQDTWYESDLKILNTILFSFPIEYLHLITGKILQRLEVYKNYQHLYDLRIAILLNLSTLYLYNQDKNMCKQICYTLLEDAKNKKSYDRLAICYVRIGICTDDSKLIQKGFSLLELTEETSMLSHLKKEVEIYYQAKER
>NC_017592.1|WP_001108795.1|137367_137955_+|hypothetical-protein
MNYNLKYLLSGIFVLVFIGFLVWMRYFNQRKEEEHSDVSFEARLDSEVKTLYKQLGLGEEPHYFLAYRYLHPWFDLAILPPTVEIFLTKIALVMVTPDELLIRNLGNGLTFTSEHHRDLRQGLIRIPKSEMKEFEIRNWKKFFVFGDFLTIKTSQHSYYLQVRDDGLQKGSLSTKHFSDLKSQDFLGLLTDKRTF

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

4370 : 58926

Streptococcus_phage(92.0%)

tRNA,integrase,holin,tail,terminase,capsid,portal,head,protease

attL 23623:23643|attR 57724:57744

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000163932.1\|4370_4940_+\|tRNA	aminoacyl-tRNA hydrolase	NA	NA	NA	NA
WP_000258091.1\|4940_8450_+	transcription-repair coupling factor	NA	NA	NA	NA
WP_001234978.1\|8507_8774_+	RNA-binding S4 domain-containing protein	NA	NA	NA	NA
WP_000041909.1\|8766_9135_+	septum formation initiator family protein	NA	NA	NA	NA
WP_001224760.1\|9254_10523_+	serine hydrolase	NA	NA	NA	NA
WP_001208986.1\|10519_11797_+\|tRNA	tRNA lysidine(34) synthetase TilS	NA	NA	NA	NA
WP_000892185.1\|11800_12343_+	hypoxanthine phosphoribosyltransferase	A0A1V0SEQ1	Hokovirus	4.4e-08	26.2
WP_000744554.1\|12358_14317_+	ATP-dependent metallopeptidase FtsH/Yme1/Tma family protein	H8ZJI5	Ostreococcus_tauri_virus	3.2e-109	45.8
WP_000588866.1\|14438_14918_+	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_000939546.1\|21774_22011_+	hypothetical protein	NA	NA	NA	NA
WP_000205044.1\|22241_23528_+	adenylosuccinate synthase	L7Y4J5	Megavirus	2.7e-72	37.1
23623:23643	attL	NA	NA	NA	NA
WP_000876732.1\|23769_24918_-\|integrase	site-specific integrase	A0A1S5SEH2	Streptococcus_phage	1.6e-217	100.0
WP_000122591.1\|25103_26027_-	3'-5' exoribonuclease	A0A1S5SEW3	Streptococcus_phage	3.5e-175	100.0
WP_000136459.1\|26039_26423_-	hypothetical protein	A0A1S5SEU6	Streptococcus_phage	1.9e-66	100.0
WP_000492031.1\|26435_26801_-	helix-turn-helix transcriptional regulator	A0A1S5SEP7	Streptococcus_phage	3.2e-63	100.0
WP_000041097.1\|27177_27399_-	hypothetical protein	A0A1S5SEP1	Streptococcus_phage	2.1e-30	100.0
WP_000389576.1\|27517_27664_+	hypothetical protein	A0A1S5SEU4	Streptococcus_phage	3.6e-18	100.0
WP_000032097.1\|27675_27879_+	helix-turn-helix transcriptional regulator	A0A1S5SEI7	Streptococcus_phage	7.7e-27	100.0
WP_001057654.1\|27895_28093_+	hypothetical protein	A0A1S5SEL5	Streptococcus_phage	3.6e-29	100.0
WP_001002946.1\|28103_28265_+	hypothetical protein	A0A1S5SEJ3	Streptococcus_phage	1.3e-21	100.0
WP_000386249.1\|28259_28685_-	hypothetical protein	A0A1S5SEI2	Streptococcus_phage	4.4e-40	100.0
WP_001002359.1\|28738_29449_+	ORF6C domain-containing protein	A0A1S5SEX2	Streptococcus_phage	1.1e-133	100.0
WP_000370959.1\|29462_29720_+	hypothetical protein	A0A1S5SEV6	Streptococcus_phage	1.2e-43	100.0
WP_000462824.1\|29805_30126_+	hypothetical protein	A0A1S5SEQ7	Streptococcus_phage	4.3e-48	100.0
WP_000391805.1\|30141_30438_+	hypothetical protein	A0A1S5SEL7	Streptococcus_phage	5.2e-48	100.0
WP_001289771.1\|30430_31237_+	phage replisome organizer N-terminal domain-containing protein	A0A1S5SEQ1	Streptococcus_phage	6.5e-125	100.0
WP_000228219.1\|31376_32147_+	ATP-binding protein	A0A1S5SEJ8	Streptococcus_phage	6.8e-140	100.0
WP_000470307.1\|32161_32356_+	hypothetical protein	A0A1S5SEM5	Streptococcus_phage	1.8e-28	100.0
WP_000891962.1\|32355_32574_+	hypothetical protein	A0A1S5SEK3	Streptococcus_phage	1.6e-38	100.0
WP_000233203.1\|33067_33235_+	hypothetical protein	A0A1S5SEY3	Streptococcus_phage	5.0e-24	100.0
WP_000872740.1\|33221_33431_+	hypothetical protein	A0A1S5SEW2	Streptococcus_phage	3.2e-28	100.0
WP_000969665.1\|33402_33720_+	hypothetical protein	A0A1S5SER7	Streptococcus_phage	3.5e-58	100.0
WP_000736390.1\|33972_34374_+	transcriptional activator	A0A1S5SER4	Streptococcus_phage	4.7e-68	100.0
WP_000397549.1\|34561_35104_+\|integrase	site-specific integrase	A0A1S5SEW4	Streptococcus_phage	1.4e-99	100.0
WP_000282427.1\|35480_35801_+	HNH endonuclease	A0A141E0N9	Streptococcus_phage	2.7e-58	100.0
WP_001118283.1\|35937_36330_+\|terminase	P27 family phage terminase small subunit	A0A1S5SEN5	Streptococcus_phage	1.6e-65	100.0
WP_000527299.1\|36322_38053_+\|terminase	terminase large subunit	A0A1S5SEL3	Streptococcus_phage	0.0e+00	100.0
WP_001002923.1\|38060_38279_+	hypothetical protein	A0A1S5SEK2	Streptococcus_phage	1.3e-32	100.0
WP_000510803.1\|38296_39499_+\|portal	phage portal protein	A0A1S5SF08	Streptococcus_phage	5.2e-227	100.0
WP_001172115.1\|39482_40058_+\|head,protease	HK97 family phage prohead protease	A0A1S5SEX0	Streptococcus_phage	2.2e-103	100.0
WP_001030357.1\|40054_41221_+\|capsid	phage major capsid protein	A0A1S5SES9	Streptococcus_phage	6.0e-188	100.0
WP_000262606.1\|41232_41502_+	hypothetical protein	A0A1S5SEN8	Streptococcus_phage	2.7e-43	100.0
WP_000370976.1\|41504_41786_+	hypothetical protein	A0A1S5SES4	Streptococcus_phage	2.5e-44	100.0
WP_000267055.1\|41772_42072_+\|head	phage head closure protein	A0A1S5SEX5	Streptococcus_phage	3.7e-49	100.0
WP_000063886.1\|42068_42416_+	HK97 gp10 family phage protein	A0A1S5SEL8	Streptococcus_phage	8.8e-47	100.0
WP_000777003.1\|42412_42736_+	hypothetical protein	A0A1S5SEP5	Streptococcus_phage	3.5e-53	100.0
WP_000191279.1\|42747_43326_+	hypothetical protein	A0A1S5SEM2	Streptococcus_phage	2.6e-107	100.0
WP_001227146.1\|43337_43757_+	hypothetical protein	A0A1S5SEL1	Streptococcus_phage	1.1e-72	100.0
WP_000918318.1\|44034_47130_+	hypothetical protein	A0A1S5SF15	Streptococcus_phage	0.0e+00	100.0
WP_000589856.1\|47126_47849_+	hypothetical protein	A0A1S5SEY1	Streptococcus_phage	1.1e-134	100.0
WP_000966215.1\|47849_54482_+\|tail	tail fiber domain-containing protein	A0A1S5SEN7	Streptococcus_phage	0.0e+00	100.0
WP_001091113.1\|54575_54779_+	hypothetical protein	A0A1S5SET3	Streptococcus_phage	5.0e-26	100.0
WP_000852241.1\|54781_55132_+	hypothetical protein	A0A1S5SEY6	Streptococcus_phage	2.8e-64	100.0
WP_001165344.1\|55140_55557_+\|holin	phage holin family protein	A0A1S5SCE8	Streptococcus_phage	1.9e-67	100.0
WP_001186219.1\|55560_55893_+\|holin	phage holin	A0A1S5SEQ5	Streptococcus_phage	7.7e-40	100.0
WP_000350505.1\|55896_56853_+	N-acetylmuramoyl-L-alanine amidase family protein	A0A1S5SEN2	Streptococcus_phage	6.7e-145	100.0
WP_000109850.1\|57073_57262_-	hypothetical protein	A0A0A0YQQ9	Streptococcus_phage	8.2e-23	83.9
WP_000291870.1\|57829_58297_+	nucleoside deaminase	NA	NA	NA	NA
57724:57744	attR	NA	NA	NA	NA
WP_000701992.1\|58482_58926_+	dUTP diphosphatase	Q2WG49	Clostridium_botulinum_D_phage	2.1e-29	47.3

DBSCAN-SWA_2

74411 : 85867

Cyanophage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000668304.1\|74411_76565_+	peptide cleavage/export ABC transporter	W8CYL7	Bacillus_phage	4.0e-44	27.8
WP_000801618.1\|76577_77927_+	HlyD family secretion protein	NA	NA	NA	NA
WP_000043304.1\|78096_78804_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A1D7SE76	Cyanophage	2.7e-42	40.1
WP_000361178.1\|79005_82731_+	phosphoribosylformylglycinamidine synthase	A6N228	Microbacterium_phage	1.6e-37	25.7
WP_000220633.1\|82823_84266_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	5.7e-55	35.1
WP_000182558.1\|84302_85325_+	phosphoribosylformylglycinamidine cyclo-ligase	A0A1D7SE90	Cyanophage	7.3e-65	43.9
WP_000717506.1\|85321_85867_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	7.4e-24	35.0

DBSCAN-SWA_3

138338 : 170046

Streptococcus_phage(40.0%)

tRNA,bacteriocin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001230165.1\|138338_138626_+\|bacteriocin	lactococcin 972 family bacteriocin	NA	NA	NA	NA
WP_000724266.1\|138677_140786_+\|bacteriocin	bacteriocin-associated integral membrane family protein	NA	NA	NA	NA
WP_000571038.1\|140782_141424_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.1e-23	35.8
WP_001038476.1\|141630_142437_+	transporter substrate-binding domain-containing protein	NA	NA	NA	NA
WP_096001214.1\|142402_142873_+	argininosuccinate synthase	NA	NA	NA	NA
WP_001189277.1\|144652_144973_-	hypothetical protein	NA	NA	NA	NA
WP_000424422.1\|145731_146112_+\|bacteriocin	SP_0115 family bacteriocin-like peptide	NA	NA	NA	NA
WP_001268150.1\|146513_147377_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_001838391.1\|147842_150062_+	peptidase domain-containing ABC transporter	W8CYL7	Bacillus_phage	2.3e-39	25.5
WP_001096141.1\|150054_150522_+	hypothetical protein	NA	NA	NA	NA
WP_000781024.1\|150518_151871_+	HlyD family efflux transporter periplasmic adaptor subunit	NA	NA	NA	NA
WP_000424429.1\|152015_152387_+\|bacteriocin	SPH_0218 family bacteriocin-like peptide	NA	NA	NA	NA
WP_000909532.1\|152394_152607_+	hypothetical protein	NA	NA	NA	NA
WP_000201420.1\|152980_153208_+	hypothetical protein	NA	NA	NA	NA
WP_001808813.1\|153364_154423_+	hypothetical protein	NA	NA	NA	NA
WP_001838392.1\|154738_155716_+	hypothetical protein	NA	NA	NA	NA
WP_000424406.1\|156092_156467_+\|bacteriocin	SPH_0224 family bacteriocin-like peptide	NA	NA	NA	NA
WP_000619811.1\|156674_157577_+	hypothetical protein	NA	NA	NA	NA
WP_000424445.1\|157632_157986_+	hypothetical protein	NA	NA	NA	NA
WP_000072927.1\|157982_158711_+	hypothetical protein	NA	NA	NA	NA
WP_000770314.1\|159454_159694_+	hypothetical protein	M1Q0Z8	Streptococcus_phage	7.2e-16	54.1
WP_001808816.1\|159678_159957_+	hypothetical protein	M1Q0Z8	Streptococcus_phage	6.0e-22	52.7
WP_001035317.1\|160252_162799_+	hypothetical protein	NA	NA	NA	NA
WP_001282967.1\|163199_164321_+\|tRNA	tRNA 2-thiouridine(34) synthase MnmA	NA	NA	NA	NA
WP_000193606.1\|164461_164917_+	NUDIX hydrolase	NA	NA	NA	NA
WP_000220964.1\|164926_166840_+\|tRNA	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG	NA	NA	NA	NA
WP_000331961.1\|167173_168853_-	ribonuclease J	S0A5H7	Cellulophaga_phage	8.8e-07	30.6
WP_000639580.1\|168854_169088_-	DNA-dependent RNA polymerase auxiliary subunit epsilon family protein	NA	NA	NA	NA
WP_000977347.1\|169893_170046_-\|bacteriocin	fratricide two-peptide bacteriocin subunit CibB	NA	NA	NA	NA

DBSCAN-SWA_4

338489 : 385503

Streptococcus_phage(27.27%)

protease,transposase,integrase,holin

attL 383361:383374|attR 386942:386955

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001063431.1\|338489_340595_+\|protease	ATP-dependent Clp protease ATP-binding subunit	H6X3M6	Enterobacteria_phage	1.7e-116	37.4
WP_000032550.1\|340890_341373_-	S-ribosylhomocysteine lyase	NA	NA	NA	NA
WP_000743630.1\|341467_342952_-	DUF1846 domain-containing protein	NA	NA	NA	NA
WP_001156820.1\|343103_344711_+	alpha-glucosidase	NA	NA	NA	NA
WP_001022221.1\|344869_345043_+	hypothetical protein	NA	NA	NA	NA
WP_000664175.1\|347689_348382_+	capsular polysaccharide biosynthesis protein CpsC	A0A1X9I5E1	Streptococcus_phage	3.2e-64	56.8
WP_000684066.1\|349950_351135_+	nucleotide sugar dehydrogenase	O41091	Paramecium_bursaria_Chlorella_virus	2.1e-103	52.2
WP_000287927.1\|351150_352404_+	glycosyltransferase	Q84419	Paramecium_bursaria_Chlorella_virus	6.1e-13	25.6
WP_000756065.1\|352701_353622_+	UTP--glucose-1-phosphate uridylyltransferase GalU	A0A127AW70	Bacillus_phage	5.9e-74	50.2
WP_001808869.1\|353618_354836_+	phospho-sugar mutase	A0A1X9I671	Streptococcus_phage	1.5e-194	86.2
WP_024266168.1\|354762_355320_-\|transposase	ISL3 family transposase	A0A1S5SBP9	Streptococcus_phage	2.4e-38	45.4
WP_001032501.1\|356708_362012_+	YSIRK-type signal peptide-containing protein	NA	NA	NA	NA
WP_001040010.1\|362177_364337_-	PBP1A family penicillin-binding protein	NA	NA	NA	NA
WP_000248781.1\|364333_364930_-	Holliday junction resolvase RecU	R9TMF8	Paenibacillus_phage	9.6e-25	37.2
WP_000179549.1\|364995_365523_+	DUF1273 domain-containing protein	NA	NA	NA	NA
WP_000146522.1\|365592_365922_+	cell division regulator GpsB	NA	NA	NA	NA
WP_000711393.1\|366407_367565_+	class I SAM-dependent RNA methyltransferase	NA	NA	NA	NA
WP_000039274.1\|367577_368972_+	mid-cell-anchored protein MapZ	NA	NA	NA	NA
WP_000158781.1\|369047_370472_+	NADP-dependent phosphogluconate dehydrogenase	M4QQM4	Ostreococcus_lucimarinus_virus	1.6e-41	29.6
WP_000518011.1\|370483_371173_+	response regulator transcription factor	W8CYM9	Bacillus_phage	2.2e-12	26.1
WP_000771085.1\|371271_372294_+\|holin	choline-binding protein CbpC	NA	NA	NA	NA
WP_000771140.1\|372312_373434_+	N-acetylmuramoyl-L-alanine amidase family protein	NA	NA	NA	NA
WP_000765691.1\|373551_374784_-	MFS transporter	NA	NA	NA	NA
WP_074017684.1\|374826_375789_-	lanthionine synthetase	NA	NA	NA	NA
WP_000197317.1\|376312_376642_+\|transposase	transposase	NA	NA	NA	NA
WP_000163328.1\|376763_377642_+	mevalonate kinase	NA	NA	NA	NA
WP_000373456.1\|377623_378577_+	diphosphomevalonate decarboxylase	NA	NA	NA	NA
WP_000562427.1\|378563_379571_+	phosphomevalonate kinase	NA	NA	NA	NA
WP_000210616.1\|379554_380565_+	type 2 isopentenyl-diphosphate Delta-isomerase	NA	NA	NA	NA
WP_001224635.1\|380642_381341_+	cell wall-active antibiotics response protein	NA	NA	NA	NA
WP_000743662.1\|381337_382333_+	sensor histidine kinase	NA	NA	NA	NA
WP_000698438.1\|382346_382979_+	response regulator transcription factor	NA	NA	NA	NA
WP_001808881.1\|382979_383222_+	DNA alkylation repair protein	NA	NA	NA	NA
WP_075588398.1\|383146_383458_+	DNA alkylation repair protein	NA	NA	NA	NA
383361:383374	attL	NA	NA	NA	NA
WP_000754501.1\|383898_384138_+	hypothetical protein	NA	NA	NA	NA
WP_074186952.1\|384182_384812_+\|protease	serine protease	NA	NA	NA	NA
WP_000378125.1\|385110_385503_+\|integrase	tyrosine-type recombinase/integrase	C9E2L6	Enterococcus_phage	3.6e-20	41.4
386942:386955	attR	NA	NA	NA	NA

DBSCAN-SWA_5

798517 : 858499

Streptococcus_phage(42.86%)

tRNA,bacteriocin,integrase,holin,protease,transposase

attL 802865:802909|attR 854119:854163

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001200080.1\|798517_799732_+\|tRNA	tRNA 4-thiouridine(8) synthase ThiI	NA	NA	NA	NA
WP_001076714.1\|799868_800693_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_000546755.1\|800714_801410_+	esterase family protein	NA	NA	NA	NA
WP_001809081.1\|801467_801875_+	hypothetical protein	NA	NA	NA	NA
WP_074017630.1\|801892_802612_+	ATP-grasp domain-containing protein	NA	NA	NA	NA
802865:802909	attL	NA	NA	NA	NA
WP_000627748.1\|803119_804613_+	SAM-dependent DNA methyltransferase	J7I0U9	Acinetobacter_phage	4.0e-35	31.7
WP_000756149.1\|804625_805027_+	restriction endonuclease subunit S	NA	NA	NA	NA
WP_000260605.1\|805086_805323_+	AbrB family transcriptional regulator	NA	NA	NA	NA
WP_000158366.1\|805319_805733_+	type II toxin-antitoxin system death-on-curing family toxin	A0A0N9SKD8	Staphylococcus_phage	3.1e-14	38.5
WP_000444455.1\|805850_806816_+\|integrase	tyrosine-type recombinase/integrase	A0A2H4JAA2	uncultured_Caudovirales_phage	1.4e-33	29.6
WP_000756121.1\|806849_807956_+	restriction endonuclease subunit S	NA	NA	NA	NA
WP_000693053.1\|811607_811808_+	hypothetical protein	NA	NA	NA	NA
WP_001042995.1\|811901_812372_-	arginine repressor	NA	NA	NA	NA
WP_001212037.1\|812388_814662_-	Xaa-Pro dipeptidyl-peptidase	NA	NA	NA	NA
WP_000561512.1\|815008_818110_+	DNA polymerase III subunit alpha	A0A291AWR1	Streptomyces_phage	2.9e-112	32.4
WP_000820852.1\|818192_819200_+	6-phosphofructokinase	NA	NA	NA	NA
WP_001042809.1\|819258_820764_+	pyruvate kinase	NA	NA	NA	NA
WP_001167984.1\|821027_821276_-\|integrase	tyrosine-type recombinase/integrase	A0A1S5S8R9	Streptococcus_phage	1.7e-12	52.1
WP_000749599.1\|822515_823388_+	DUF4300 family protein	NA	NA	NA	NA
WP_000759775.1\|824336_825053_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_000617843.1\|825182_825998_-	TIGR03943 family protein	NA	NA	NA	NA
WP_000123607.1\|825994_826900_-	permease	NA	NA	NA	NA
WP_000359141.1\|827491_829621_+	RNA-binding transcriptional accessory protein	NA	NA	NA	NA
WP_000778589.1\|829607_830057_+	SprT family protein	NA	NA	NA	NA
WP_001085044.1\|830115_830388_+	PspC domain-containing protein	NA	NA	NA	NA
WP_000680760.1\|830746_830938_-	hypothetical protein	NA	NA	NA	NA
WP_000173358.1\|831367_832126_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	7.7e-27	36.3
WP_000489400.1\|832127_834116_+	ABC transporter permease	NA	NA	NA	NA
WP_164848155.1\|834157_834802_-	VIT1/CCC1 transporter family protein	NA	NA	NA	NA
WP_001153887.1\|834773_835823_-\|transposase	IS30 family transposase	H7BVY4	unidentified_phage	6.6e-37	36.0
WP_000661000.1\|836529_838005_+	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_074189415.1\|837970_838561_-\|transposase	transposase	NA	NA	NA	NA
WP_001270407.1\|838771_838909_+	hypothetical protein	NA	NA	NA	NA
WP_000366707.1\|838939_839800_+	polyamine aminopropyltransferase	A0A1C9C533	Heterosigma_akashiwo_virus	6.0e-12	30.6
WP_000088774.1\|839796_841056_+	saccharopine dehydrogenase family protein	NA	NA	NA	NA
WP_000764379.1\|841055_842183_+	carboxynorspermidine decarboxylase	NA	NA	NA	NA
WP_000969449.1\|842179_843265_+	agmatine deiminase	M1HES8	Acanthocystis_turfacea_Chlorella_virus	2.0e-89	47.5
WP_001246755.1\|843274_844150_+	N-carbamoylputrescine amidase	M1H5W0	Paramecium_bursaria_Chlorella_virus	1.1e-77	50.0
WP_000593608.1\|844330_845140_-	Cof-type HAD-IIB family hydrolase	NA	NA	NA	NA
WP_000602451.1\|845411_845633_+\|bacteriocin	SP_0924 family bacteriocin-like peptide	NA	NA	NA	NA
WP_000745371.1\|845686_846358_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_001025710.1\|846599_847508_+	LysR family transcriptional regulator	A0A2P0ZL89	Lactobacillus_phage	3.1e-06	27.7
WP_000745389.1\|847504_847966_+	signal peptidase II	NA	NA	NA	NA
WP_000403195.1\|847955_848843_+	RluA family pseudouridine synthase	A0A2H4UV25	Bodo_saltans_virus	1.3e-09	28.0
WP_000728261.1\|848845_850741_+\|holin	phosphorylcholine esterase CbpE	I2E8W4	Clostridium_phage	1.6e-12	24.8
WP_074186894.1\|850820_851951_+	glutamate 5-kinase	A0A1X9I5D0	Streptococcus_phage	1.5e-114	58.4
WP_000254695.1\|851960_853223_+	glutamate-5-semialdehyde dehydrogenase	A0A1X9I5D4	Streptococcus_phage	3.8e-140	64.5
WP_000689706.1\|853226_854024_+	pyrroline-5-carboxylate reductase	A0A1X9I6T5	Streptococcus_phage	8.0e-59	50.2
WP_000033362.1\|854243_854882_+	dTMP kinase	M1PSC7	Streptococcus_phage	9.8e-76	68.1
854119:854163	attR	NA	NA	NA	NA
WP_000806714.1\|854878_855769_+	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	4.9e-73	51.7
WP_000358228.1\|855808_856126_+	DNA replication initiation control protein YabA	M1PFV3	Streptococcus_phage	2.9e-28	60.0
WP_001166894.1\|856128_856998_+	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	2.5e-114	75.4
WP_001261453.1\|857224_857743_+	ClbS/DfsB family four-helix bundle protein	NA	NA	NA	NA
WP_000345254.1\|857851_858499_+	replication initiator protein A	A0A2P0VK56	Streptococcus_phage	7.0e-13	33.7

DBSCAN-SWA_6

1114330 : 1127227

Bacillus_phage(22.22%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001152997.1\|1114330_1116799_-	DNA gyrase subunit A	G3M9Z5	Bacillus_virus	1.2e-105	35.5
WP_000204733.1\|1116992_1117979_+	L-lactate dehydrogenase	NA	NA	NA	NA
WP_000731127.1\|1118327_1119023_-	potassium channel family protein	A0A1B0Y2S3	Lactobacillus_phage	4.7e-23	47.7
WP_001812387.1\|1119069_1119324_-	type II toxin-antitoxin system RelE/ParE family toxin	A0A1S5S8E8	Streptococcus_phage	7.0e-17	51.2
WP_000208080.1\|1119325_1119568_-	hypothetical protein	NA	NA	NA	NA
WP_001289493.1\|1119658_1120468_-	MBL fold metallo-hydrolase	A0A0C5AFC1	Paenibacillus_phage	1.8e-34	39.0
WP_000886210.1\|1120469_1121819_-	cell wall metabolism sensor histidine kinase VicK	W8CYF6	Bacillus_phage	1.8e-34	34.6
WP_000722076.1\|1121811_1122516_-	response regulator transcription factor	W8CYM9	Bacillus_phage	2.8e-39	39.8
WP_000886147.1\|1122570_1123746_-	A/G-specific adenine glycosylase	G3CB03	Aeropyrum_pernix_spindle-shaped_virus	8.8e-22	29.8
WP_000845287.1\|1124074_1125745_-	formate--tetrahydrofolate ligase	NA	NA	NA	NA
WP_000699489.1\|1125974_1126664_+	phosphopantothenate--cysteine ligase	Q9HH70	Methanothermobacter_phage	2.9e-17	31.6
WP_001284130.1\|1126675_1127227_+	phosphopantothenoylcysteine decarboxylase	A0A1V0S7W6	Shearwaterpox_virus	5.2e-25	36.1

DBSCAN-SWA_7

1162958 : 1222635

Bacillus_phage(21.43%)

protease,holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000411215.1\|1162958_1163828_-\|holin	choline kinase LicA	NA	NA	NA	NA
WP_000609890.1\|1163844_1164867_-	alcohol dehydrogenase catalytic domain-containing protein	NA	NA	NA	NA
WP_000638502.1\|1164871_1165579_-	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	NA	NA	NA	NA
WP_000835915.1\|1165914_1167402_+	type IV teichoic acid flippase TacF	NA	NA	NA	NA
WP_000811874.1\|1167411_1168215_+\|holin	phosphorylcholine transferase LicD	A0A1V0SD50	Indivirus	5.3e-10	27.1
WP_001199652.1\|1168216_1169026_+\|holin	phosphorylcholine transferase LicD	A0A1V0SD50	Indivirus	9.1e-10	30.3
WP_001126438.1\|1169300_1172477_-	carbamoyl-phosphate synthase large subunit	NA	NA	NA	NA
WP_000166701.1\|1172789_1173869_-	glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit	R4TGJ8	Halovirus	6.3e-59	35.9
WP_001293820.1\|1173918_1174842_-	aspartate carbamoyltransferase catalytic subunit	M1HGA5	Paramecium_bursaria_Chlorella_virus	6.7e-25	31.7
WP_000850024.1\|1174860_1175382_-	bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR	NA	NA	NA	NA
WP_000603771.1\|1175592_1176222_-	endonuclease III	NA	NA	NA	NA
WP_000773233.1\|1176221_1176764_-	DUF177 domain-containing protein	NA	NA	NA	NA
WP_000389608.1\|1176933_1177251_+	hypothetical protein	NA	NA	NA	NA
WP_000558894.1\|1177489_1179049_+	ABC-F family ATP-binding cassette domain-containing protein	A0A1B0RXA0	Streptococcus_phage	7.1e-27	25.5
WP_000895724.1\|1179197_1180097_-\|protease	zinc metalloprotease HtpX	NA	NA	NA	NA
WP_000219827.1\|1180098_1180659_-	LemA family protein	A0A1X9IGG1	Lactococcus_phage	8.8e-12	32.5
WP_000801941.1\|1180752_1181466_+	16S rRNA (guanine(527)-N(7))-methyltransferase RsmG	NA	NA	NA	NA
WP_001809228.1\|1181719_1183003_+	uracil transporter	Q9KX94	Enterobacteria_phage	1.8e-60	35.3
WP_000863637.1\|1183197_1184769_-	signal recognition particle protein	NA	NA	NA	NA
WP_000402059.1\|1184780_1185113_-	putative DNA-binding protein	NA	NA	NA	NA
WP_000702356.1\|1185202_1185580_-	DUF1934 domain-containing protein	NA	NA	NA	NA
WP_001003495.1\|1185651_1186956_+	HD domain-containing protein	A0A1B1ISR1	uncultured_Mediterranean_phage	7.5e-30	35.1
WP_000023531.1\|1186968_1187775_+	sugar-phosphatase	NA	NA	NA	NA
WP_001068669.1\|1187942_1188290_-	50S ribosomal protein L19	NA	NA	NA	NA
WP_000237416.1\|1188408_1188738_-	fluoride efflux transporter CrcB	A0A2H4PQR0	Staphylococcus_phage	6.3e-10	37.8
WP_000712092.1\|1188731_1189106_-	fluoride efflux transporter CrcB	NA	NA	NA	NA
WP_000362440.1\|1189102_1189369_-	chorismate mutase	NA	NA	NA	NA
WP_001162128.1\|1189484_1189928_-	flavodoxin	A7KUZ7	Bacillus_phage	1.6e-08	37.4
WP_000401770.1\|1190031_1190967_+	bifunctional oligoribonuclease/PAP phosphatase NrnA	NA	NA	NA	NA
WP_001808393.1\|1191020_1191305_+	type B 50S ribosomal protein L31	NA	NA	NA	NA
WP_000028151.1\|1191361_1191580_-	hypothetical protein	NA	NA	NA	NA
WP_000199536.1\|1192688_1194035_+	NADP-specific glutamate dehydrogenase	NA	NA	NA	NA
WP_000711943.1\|1194530_1194701_-	hypothetical protein	NA	NA	NA	NA
WP_000941987.1\|1197652_1197949_-	hypothetical protein	NA	NA	NA	NA
WP_000093669.1\|1197961_1198105_-	hypothetical protein	NA	NA	NA	NA
WP_000869751.1\|1198106_1198394_-	hypothetical protein	NA	NA	NA	NA
WP_000807141.1\|1199187_1199325_-	hypothetical protein	NA	NA	NA	NA
WP_000945309.1\|1199457_1200777_-	FtsX-like permease family protein	NA	NA	NA	NA
WP_000356590.1\|1200779_1201520_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.0e-23	34.8
WP_000656069.1\|1201534_1202155_-	ATP-binding cassette domain-containing protein	G9BWD6	Planktothrix_phage	2.0e-12	34.2
WP_001058017.1\|1202338_1203742_-	phosphotransferase	NA	NA	NA	NA
WP_000821274.1\|1204370_1204958_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_000840776.1\|1204960_1205194_-	hypothetical protein	NA	NA	NA	NA
WP_000566553.1\|1205206_1205587_-	hypothetical protein	NA	NA	NA	NA
WP_001814249.1\|1205579_1205903_-	hypothetical protein	NA	NA	NA	NA
WP_001168347.1\|1206164_1206335_-	hypothetical protein	NA	NA	NA	NA
WP_001196960.1\|1206521_1206890_-	50S ribosomal protein L7/L12	NA	NA	NA	NA
WP_001287278.1\|1206965_1207466_-	50S ribosomal protein L10	NA	NA	NA	NA
WP_000862484.1\|1207715_1208975_-	TRZ/ATZ family protein	NA	NA	NA	NA
WP_000828831.1\|1209231_1210980_-	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	3.7e-48	29.3
WP_000681689.1\|1210981_1212706_-	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	3.0e-42	27.0
WP_000818203.1\|1212763_1213702_-	peptide-methionine (R)-S-oxide reductase MsrB	NA	NA	NA	NA
WP_000692438.1\|1213951_1214821_-	homoserine kinase	NA	NA	NA	NA
WP_000216376.1\|1214822_1216109_-	homoserine dehydrogenase	NA	NA	NA	NA
WP_000782676.1\|1216259_1216997_-	adaptor protein MecA	NA	NA	NA	NA
WP_000461498.1\|1217196_1218231_-	hypothetical protein	NA	NA	NA	NA
WP_000565097.1\|1218259_1219693_-	O-antigen polysaccharide polymerase Wzy family protein	NA	NA	NA	NA
WP_000446977.1\|1219708_1220695_-	glycosyltransferase family 2 protein	NA	NA	NA	NA
WP_000225903.1\|1220696_1221800_-	glycosyltransferase	NA	NA	NA	NA
WP_001061988.1\|1221789_1222635_-\|holin	phosphorylcholine transferase LicD	NA	NA	NA	NA

DBSCAN-SWA_8

1266355 : 1320736

Bacillus_virus(16.67%)

tRNA,transposase,holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001090165.1\|1266355_1267384_+\|tRNA	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	NA	NA	NA	NA
WP_074017658.1\|1268044_1269172_-	G5 domain-containing protein	NA	NA	NA	NA
WP_000835659.1\|1269886_1270438_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_000058033.1\|1270787_1271612_-	ammonia-dependent NAD(+) synthetase	G3MA24	Bacillus_virus	1.8e-74	57.5
WP_000283157.1\|1271608_1273069_-	nicotinate phosphoribosyltransferase	G3MA18	Bacillus_virus	3.0e-104	43.5
WP_000797184.1\|1273184_1273673_-	hypothetical protein	NA	NA	NA	NA
WP_001107505.1\|1273662_1273872_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_000640911.1\|1274256_1274709_-	hypothetical protein	NA	NA	NA	NA
WP_000773444.1\|1274772_1274985_-	hypothetical protein	NA	NA	NA	NA
WP_001809119.1\|1276849_1277161_-	hypothetical protein	NA	NA	NA	NA
WP_000169080.1\|1277175_1278462_-	U32 family peptidase	Q6DW11	Phage_TP	1.6e-40	31.3
WP_001262531.1\|1279085_1279268_+	ApaLI family restriction endonuclease	NA	NA	NA	NA
WP_078131890.1\|1279277_1279631_+	ApaLI family restriction endonuclease	NA	NA	NA	NA
WP_000217307.1\|1279638_1280829_+	site-specific DNA-methyltransferase	A0A0H3UZ66	Geobacillus_virus	7.0e-43	37.4
WP_000122904.1\|1281343_1282336_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_000708373.1\|1282495_1284250_+	ABC transporter ATP-binding protein	F2Y352	Organic_Lake_phycodnavirus	1.3e-24	32.6
WP_000657836.1\|1284233_1285955_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	6.4e-29	26.9
WP_000368971.1\|1285965_1286550_+	MptD family putative ECF transporter S component	NA	NA	NA	NA
WP_001141942.1\|1286549_1287245_+	energy-coupling factor transporter transmembrane protein EcfT	NA	NA	NA	NA
WP_000229369.1\|1287232_1288597_+	ABC transporter ATP-binding protein	A0A1V0SE00	Indivirus	3.3e-20	35.5
WP_001809122.1\|1289051_1289210_-\|transposase	transposase domain-containing protein	NA	NA	NA	NA
WP_001809123.1\|1289802_1290015_-\|transposase	transposase	NA	NA	NA	NA
WP_000484475.1\|1290023_1290329_-\|transposase	IS66 family transposase zinc-finger binding domain-containing protein	NA	NA	NA	NA
WP_000691853.1\|1290315_1290510_-\|transposase	transposase	NA	NA	NA	NA
WP_014632422.1\|1290706_1291030_-	IS66 family insertion sequence element accessory protein TnpB	NA	NA	NA	NA
WP_001136125.1\|1290935_1291196_-	hypothetical protein	NA	NA	NA	NA
WP_000065723.1\|1291499_1293062_-	glutamine-hydrolyzing GMP synthase	A0A1V0SH76	Hokovirus	1.4e-19	32.8
WP_000936189.1\|1293203_1293902_+	GntR family transcriptional regulator	NA	NA	NA	NA
WP_000071669.1\|1293944_1294841_-	EamA family transporter	NA	NA	NA	NA
WP_000872215.1\|1294849_1295785_-	serine hydrolase	NA	NA	NA	NA
WP_001102214.1\|1295781_1296507_-	proteinase	NA	NA	NA	NA
WP_000290648.1\|1296590_1297226_-\|holin	1-alkyl-2-acetylglycerophosphocholine esterase	A0A2K9L661	Tupanvirus	4.3e-07	28.2
WP_000972925.1\|1297227_1298055_-	Cof-type HAD-IIB family hydrolase	NA	NA	NA	NA
WP_001272961.1\|1299654_1300266_+	peptide deformylase	E3SLL2	Synechococcus_phage	4.9e-16	42.4
WP_000855734.1\|1300310_1301039_+	23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB	NA	NA	NA	NA
WP_000272311.1\|1301076_1301988_-	thioredoxin-disulfide reductase	G3MA85	Bacillus_virus	2.9e-89	51.5
WP_000926599.1\|1302053_1302278_-	DUF4059 family protein	NA	NA	NA	NA
WP_000590985.1\|1302355_1303099_-	amino acid ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.6e-29	41.0
WP_001103449.1\|1303098_1303899_-	amino acid ABC transporter permease	NA	NA	NA	NA
WP_000889093.1\|1304056_1304413_-	arsenate reductase family protein	M1PLC0	Streptococcus_phage	1.2e-33	57.3
WP_001170344.1\|1304406_1304937_-	methylated-DNA--[protein]-cysteine S-methyltransferase	M1PFU9	Streptococcus_phage	1.4e-46	54.3
WP_000405832.1\|1304936_1305431_-	GNAT family N-acetyltransferase	M1PSC3	Streptococcus_phage	1.9e-42	52.1
WP_000858730.1\|1305565_1306012_+	DUF1836 domain-containing protein	NA	NA	NA	NA
WP_001097984.1\|1306008_1306656_+	hemolysin III family protein	NA	NA	NA	NA
WP_000689948.1\|1306676_1307258_-	pyridoxal 5'-phosphate synthase glutaminase subunit PdxT	NA	NA	NA	NA
WP_000138517.1\|1307258_1308134_-	pyridoxal 5'-phosphate synthase lyase subunit PdxS	NA	NA	NA	NA
WP_000036789.1\|1308285_1309665_-	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_000175416.1\|1309958_1310882_+	FAD:protein FMN transferase	NA	NA	NA	NA
WP_000915924.1\|1310941_1311547_+	NAD(P)H-dependent oxidoreductase	A0A2P0ZL77	Lactobacillus_phage	7.7e-54	54.2
WP_000673687.1\|1311565_1312810_+	NAD(P)H-dependent oxidoreductase	A0A2P0ZL82	Lactobacillus_phage	2.2e-55	52.1
WP_000371287.1\|1313032_1313290_-	DUF896 family protein	NA	NA	NA	NA
WP_000164753.1\|1313331_1315368_-\|tRNA	glycine--tRNA ligase subunit beta	NA	NA	NA	NA
WP_000038744.1\|1315627_1316545_-\|tRNA	glycine--tRNA ligase subunit alpha	NA	NA	NA	NA
WP_000429564.1\|1316739_1317501_-	hypothetical protein	NA	NA	NA	NA
WP_001099678.1\|1317773_1318616_-	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	1.3e-51	40.2
WP_042672207.1\|1318729_1320121_-	polysaccharide deacetylase family protein	NA	NA	NA	NA
WP_001809132.1\|1320355_1320736_-\|transposase	PD-(D/E)XK nuclease family transposase	NA	NA	NA	NA

DBSCAN-SWA_9

2014710 : 2023464

Streptococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000510408.1\|2014710_2015550_-	energy-coupling factor transporter ATPase	A0A2K9L3Z8	Tupanvirus	3.0e-16	29.8
WP_000835715.1\|2015534_2016362_-	energy-coupling factor transporter ATPase	G9BWD6	Planktothrix_phage	2.8e-22	32.9
WP_000712141.1\|2016358_2016904_-	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase	NA	NA	NA	NA
WP_001227958.1\|2016914_2017736_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_000170216.1\|2017777_2019061_-	insulinase family protein	A0A167R9K4	Powai_lake_megavirus	1.2e-16	30.5
WP_000424281.1\|2019057_2020308_-	insulinase family protein	A0A1X9I714	Streptococcus_phage	9.2e-94	42.5
WP_000455903.1\|2020466_2020835_+	S4 domain-containing protein YaaA	A0A1X9I5V8	Streptococcus_phage	7.0e-18	57.3
WP_000266660.1\|2020837_2021935_+	DNA replication/repair protein RecF	NA	NA	NA	NA
WP_000073423.1\|2021985_2023464_-	IMP dehydrogenase	A0A1V0SHK8	Klosneuvirus	2.2e-94	40.5

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage