CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_021003	Streptococcus pneumoniae SPN032672, complete genome	2 crisprs	cas3,RT,DEDDh,DinG	0	0	8	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_021003_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021003_1

465271-465407

Orphan

Consensus_repeat	Method
ACTTCTGGTGTCGGTACATTTGGTGTTGG	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_021003_1

>merge|NC_021003|1|465271-465407|CRISPRCasFinder
ACTGGTTTAACCGGTACTTCTGGTGTTGGAACAGCTGGAGTTGGTTGTACTGGCACTTCTGGTGTCGGTACATTTGGTGTTGGTTGCGCTGGCACAGGTTTAACCGGTACTTCTGGTGTCGGCACATTTGGTGTTGG

>NC_021003|1|1|465271-465407|CRISPRCasFinder
ACTGGTTTAACCGGTACTTCTGGTGTTGG	AACAGCTGGAGTTGGTTGTACTGGC
ACTTCTGGTGTCGGTACATTTGGTGTTGG	TTGCGCTGGCACAGGTTTAACCGGT
ACTTCTGGTGTCGGCACATTTGGTGTTGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_021003.1\|WP_001151785.1\|460124_460415_-\|30S-ribosomal-protein-S6	unknown	unknown	gnl\|CDD\|179034
NC_021003.1\|WP_000813919.1\|480739_481924_+\|CDF-family-manganese-efflux-transporter-MntE	unknown	unknown	gnl\|CDD\|223131
NC_021003.1\|WP_001138808.1\|483934_485119_-\|CCA-tRNA-nucleotidyltransferase	unknown	unknown	gnl\|CDD\|237339
NC_021003.1\|WP_000689596.1\|457315_457675_-\|S1-RNA-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|180908
NC_021003.1\|WP_001279136.1\|482066_483938_-\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NC_021003.1\|WP_161801414.1\|460567_461914_-\|asparagine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235176
NC_021003.1\|WP_000565218.1\|461929_462295_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319923
NC_021003.1\|WP_001245196.1\|472129_473614_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|285470
NC_021003.1\|WP_000508269.1\|474471_474636_-\|YczI-family-protein	unknown	unknown	gnl\|CDD\|315732
NC_021003.1\|WP_000032458.1\|477739_480436_-\|cation-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319781
NC_021003.1\|WP_000609607.1\|459642_460113_-\|single-stranded-DNA-binding-protein-SsbA	unknown	unknown	gnl\|CDD\|180915
NC_021003.1\|WP_000068664.1\|459371_459611_-\|30S-ribosomal-protein-S18	unknown	unknown	gnl\|CDD\|178997
NC_021003.1\|WP_000777779.1\|462287_463475_-\|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl\|CDD\|235596
NC_021003.1\|WP_000412213.1\|476409_476820_-\|peptide-deformylase	unknown	unknown	gnl\|CDD\|181704
NC_021003.1\|WP_000039618.1\|464280_464829_+\|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223508
NC_021003.1\|WP_000339028.1\|457676_459077_-\|bifunctional-Cof-type-HAD-IIB-family-hydrolase/peptidylprolyl-isomerase	unknown	unknown	gnl\|CDD\|223725
NC_021003.1\|WP_000697775.1\|473664_474393_-\|peroxide-stress-protein-YaaA	unknown	unknown	gnl\|CDD\|234999
NC_021003.1\|WP_000822864.1\|474802_476398_-\|hypothetical-protein	unknown	unknown	unknown
NC_021003.1\|WP_001277403.1\|476935_477727_-\|glutathione-dependent-disulfide-bond-oxidoreductase	unknown	unknown	gnl\|CDD\|183298
NC_021003.1\|WP_000747253.1\|463471_463960_-\|DUF5590-domain-containg-protein	unknown	unknown	gnl\|CDD\|227656

Protein	Function_ID	Function_description	E-value
NC_021003.1\|WP_001151785.1\|460124_460415_-\|30S-ribosomal-protein-S6	gnl\|CDD\|179034	PRK00453, rpsF, 30S ribosomal protein S6; Reviewed.	1.40041e-37
NC_021003.1\|WP_000813919.1\|480739_481924_+\|CDF-family-manganese-efflux-transporter-MntE	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	9.07128e-101
NC_021003.1\|WP_001138808.1\|483934_485119_-\|CCA-tRNA-nucleotidyltransferase	gnl\|CDD\|237339	PRK13299, PRK13299, tRNA CCA-pyrophosphorylase; Provisional.	0
NC_021003.1\|WP_000689596.1\|457315_457675_-\|S1-RNA-binding-domain-containing-protein	gnl\|CDD\|180908	PRK07252, PRK07252, S1 RNA-binding domain-containing protein.	7.1116e-79
NC_021003.1\|WP_001279136.1\|482066_483938_-\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	0
NC_021003.1\|WP_161801414.1\|460567_461914_-\|asparagine--tRNA-ligase	gnl\|CDD\|235176	PRK03932, asnC, asparaginyl-tRNA synthetase; Validated.	0
NC_021003.1\|WP_000565218.1\|461929_462295_-\|VOC-family-protein	gnl\|CDD\|319923	cd07262, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	2.44563e-33
NC_021003.1\|WP_001245196.1\|472129_473614_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|285470	pfam08270, PRD_Mga, M protein trans-acting positive regulator (MGA) PRD domain. Mga is a DNA-binding protein that activates the expression of several important virulence genes in group A streptococcus in response to changing environmental conditions. This corresponds to the PRD like region.	9.24091e-77
NC_021003.1\|WP_000508269.1\|474471_474636_-\|YczI-family-protein	gnl\|CDD\|315732	pfam13129, DUF3953, Protein of unknown function (DUF3953). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 47 and 76 amino acids in length.	0.000993842
NC_021003.1\|WP_000032458.1\|477739_480436_-\|cation-translocating-P-type-ATPase	gnl\|CDD\|319781	cd02089, P-type_ATPase_Ca_prok, prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL and Listeria monocytogenes LMCA1. Ca(2+) transport ATPase is a plasma membrane protein which pumps Ca(2+) ion out of the cytoplasm. This prokaryotic subfamily includes the Ca(2+)-ATPase Synechococcus elongatus PacL, Listeria monocytogenes Ca(2+)-ATPase 1 (LMCA1) which has a low Ca(2+) affinity and a high pH optimum (pH about 9) and may remove Ca(2+) from the microorganism in environmental conditions when e.g. stressed by high Ca(2+) and alkaline pH, and the Bacillus subtilis putative P-type Ca(2+)-transport ATPase encoded by the yloB gene, which is expressed during sporulation. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NC_021003.1\|WP_000609607.1\|459642_460113_-\|single-stranded-DNA-binding-protein-SsbA	gnl\|CDD\|180915	PRK07275, PRK07275, single-stranded DNA-binding protein; Provisional.	1.66017e-101
NC_021003.1\|WP_000068664.1\|459371_459611_-\|30S-ribosomal-protein-S18	gnl\|CDD\|178997	PRK00391, rpsR, 30S ribosomal protein S18; Reviewed.	3.32721e-37
NC_021003.1\|WP_000777779.1\|462287_463475_-\|pyridoxal-phosphate-dependent-aminotransferase	gnl\|CDD\|235596	PRK05764, PRK05764, aspartate aminotransferase; Provisional.	0
NC_021003.1\|WP_000412213.1\|476409_476820_-\|peptide-deformylase	gnl\|CDD\|181704	PRK09218, PRK09218, peptide deformylase; Validated.	6.64917e-89
NC_021003.1\|WP_000039618.1\|464280_464829_+\|NAD(P)H-dependent-oxidoreductase	gnl\|CDD\|223508	COG0431, COG0431, Predicted flavoprotein [General function prediction only].	1.06789e-32
NC_021003.1\|WP_000339028.1\|457676_459077_-\|bifunctional-Cof-type-HAD-IIB-family-hydrolase/peptidylprolyl-isomerase	gnl\|CDD\|223725	COG0652, PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones].	1.96309e-61
NC_021003.1\|WP_000697775.1\|473664_474393_-\|peroxide-stress-protein-YaaA	gnl\|CDD\|234999	PRK02101, PRK02101, peroxide stress protein YaaA.	5.15942e-96
NC_021003.1\|WP_001277403.1\|476935_477727_-\|glutathione-dependent-disulfide-bond-oxidoreductase	gnl\|CDD\|183298	PRK11752, PRK11752, putative S-transferase; Provisional.	0
NC_021003.1\|WP_000747253.1\|463471_463960_-\|DUF5590-domain-containg-protein	gnl\|CDD\|227656	COG5353, COG5353, Uncharacterized protein conserved in bacteria [Function unknown].	3.22216e-58

>NC_021003.1|WP_000039618.1|464280_464829_+|NAD(P)H-dependent-oxidoreductase
MSKKVLFIVGSLRQGSFNHQMALEAEKALAGKAEVSYLDYSALPLFSQDLEVPTHPAVAAAREAVLVADAIWIFSPVYNFSIPGTVKNLLDWLSRALDLSDTRGVSALQDKFVTVSSVANAGHDQLFAIYKDLLPFIRTQGVGDFTAARVNDSAWADGKLVLEETVLNSLEKQAQDLVEAIQ
>NC_021003.1|WP_000747253.1|463471_463960_-|DUF5590-domain-containg-protein
MKKRQNKAKNNLLWQYGLGMTILFVVISASFLYMVSLSMKPYQTAKSEGEKLAQQYAGLEQADQVDLYNGLESYYSVLGRNKQQEALAVLIGKDDHKIYVYQLNQGVSQEKAETVSKEKGAGEIDKIIFGRYQDKPIWEVKSGSDFYLVDFETGALVNKEGL
>NC_021003.1|WP_000777779.1|462287_463475_-|pyridoxal-phosphate-dependent-aminotransferase
MKLSNRVLEMEESVTLAAGARAKALKAEGRDILSLTLGEPDFTTPKNIQDAAIASIRDGRASFYTVTSGLPELKAAVNSYFERFYGYSVASNQVTVAAGAKYSLYTFFMAVVNPGDEVIIPTPYWVSYGDQVKMAEGVPVFVSAKEDNHFKVTVEQLEAARTDKTKVLVLNSPSNPTGMIYTREELLAIGNWAVENDILILADDIYGRLVYNGHEFTPISSLSEAIRKQTVVINGVSKTYAMTGWRIGYAVGEADIIAAMSKIAGQTTSNPSAVAQYAAVEALSGEQDTVESMRQAFEERLNTIYPLLAEVPGFEVVKPQGAFYLFPNVKKAMEMKGYTDVTDFTTVILEEAEVALVTGAGFGAPENVRLSYATDLDTLKEAVERLKAFMGSEND
>NC_021003.1|WP_000565218.1|461929_462295_-|VOC-family-protein
MIDHFEIKVKDLQISEGFYRSFLAPLDYKLAFKTSSLISFLSPNSPHPGGDFWLTQGTQDPVHFAFLAENKEEVQACYEAGLEAGGRDNGAPGYRSEHPIYYAAFMIDLDGNNIEVVCHKE
>NC_021003.1|WP_161801414.1|460567_461914_-|asparagine--tRNA-ligase
MMTKRVTIIDVKDYVGQEVTIGAWVANKSGKGKIAFLQLRDGTAFFQGVAFKPNFVEKFGEEVGLEKFDVIKRLSQETSVYVTGIVKEDERSKFGYELDITDIEVIGESQDYPITPKEHGTDFLMDNRHLWLRSRKQVAVLQIRNAIIYATYEFFDKNGFMKFDSPILSGNAAEDSTELFETDYFGTPAYLSQSGQLYLEAGAMALGRVFDFGPVFRAEKSKTRRHLTEFWMMDAEYSYLTHDESLDLQEAYVKALLQGVLDRAPQALETLERDTELLKRYIAEPFKRITYDQAIDLLQEHENDEDADYEHLEHGDDFGSPHETWISNHFGVPTFVMNYPAAIKAFYMKPVPGNPERVLCADLLAPEGYGEIIGGSMREEDYDALVAKMDELGMDRTEYEFYLDLRKYGTVPHGGFGIGIERMVTFAAGTKHIREAIPFPRMLHRIKP
>NC_021003.1|WP_001151785.1|460124_460415_-|30S-ribosomal-protein-S6
MAKYEILYIIRPNIEEEAKNALVARFDSILTDNGATVVESKTWEKRRLAYEIQDFREGLYHIVNVEANDDAALKEFDRLSKINADILRHMIVKIDA
>NC_021003.1|WP_000609607.1|459642_460113_-|single-stranded-DNA-binding-protein-SsbA
MINNVVLVGRMTRDAELRYTPSNVAVATFTLAVNRTFKSQNGEREADFINVVMWRQQAENLANWAKKGSLIGVTGRIQTRSYDNQQGQRVYVTEVVAENFQMLESRSVREGHTGGAYSAPTANYSAPTNSVPDFSRNENPFGATNPLDISDDDLPF
>NC_021003.1|WP_000068664.1|459371_459611_-|30S-ribosomal-protein-S18
MAQQRRGGFKRRKKVDYIAANKIEYVDYKDTELLSRFVSERGKILPRRVTGTSAKNQRKVTTAIKRARVMALMPFVNED
>NC_021003.1|WP_000339028.1|457676_459077_-|bifunctional-Cof-type-HAD-IIB-family-hydrolase/peptidylprolyl-isomerase
MDAKLRYKAKKIKIVFFDIDDTLRNSKTGFIPTTIPTVFKQLREKGILTGIASGRGIFGVVPEIRDLKPDFFVTLNGAYIEDKKGQVIYQHQIEKSYVEEYISWAKQEGIEYGLVGSHDAKLSTRTDMMSEAINPIYPDLDVDPDFHEKEDIYQMWTFEDKGDDLHLPDSLSDKLRMVRWHQHSSDIVPISGSKATGVEKVVEHLGLKPEKVMVFGDGLNDLELFDYAGISVAMGISHDKIKEKADYITKTLEEDGIFDALEVFGMVEKELHFPQVDIETVEGPLATIKTNHGDLRIKLFPEHAPKTVANFVSLSKDGYYDGVIFHRIIKDFMIQGGDPTGTGMGGESIYGESFEDEFSEELYNIRGALSMANAGPNTNGSQFFIVQNQHLPYSKKEITRGGWPEPIAEIYANQGGTPHLDRRHTVFGQLADEASYAVLDVIAAVETGAMDKPVEDVVIETIEIED
>NC_021003.1|WP_000689596.1|457315_457675_-|S1-RNA-binding-domain-containing-protein
MKIGDKLKGRITGIQPYGAFVELETGDTGLIHISEIRTGFIENIHETLKVDEEVQVQVVDLDEFTGKASLSIRTLEEEKYQFPRRRRFSSDRFNYGFAPFRRMLPIWTGEALHHLKKKK
>NC_021003.1|WP_001245196.1|472129_473614_+|helix-turn-helix-domain-containing-protein
MRNLLSTKVQRQLRLMETLIQNRNWMKLHELAEKLGCTERILKSDLNELRIAFPSINIQSSVNGIMIDLEVNTSVEDIYQYFLANSQSFQLLEYMFFNEGLPIYRTIENLYFSSANLYRLGRNITKVLSSQFQIELSFTPSEIRGNEIDIRYFFAQYFSERYYFLDWPFPDLPEEDLTEFADFFYKITNYPMRFSIYRMYKLMIAISIHRVKNGHFIDLPNHFYKEYYPLLKSIPNFQETLAYFSKHFGLEMTPDTIAQIFISFLQNDIFLDPQEFFNSLEDNSQARYSYQLLSQILERLSKQYKITFTNHDELIWHLHNTAFFERQEIFSTPILFEQKALTIKKFEGYFPDFMGSARQELAQYRQAIGQHDHPEQLEHLMYTILTHAENLSTQLLENRPPIKVLIISNFDHAISLTFVDMLSYYCNNRFTFDIWDELKTSPEILNQTDYDIIVSNFYISGITKKFICRNHLSIMNLVNHLNTLSNEIHLSNTL
>NC_021003.1|WP_000697775.1|473664_474393_-|peroxide-stress-protein-YaaA
MKILIPTAKEMNTDLPSIEAIPLKPESQTVLDALALYSASQLESFYKVSAEKAAEEFQNIQALKRQTAQHYPALKLFDGLMYRNIKRDKLTEAEQDYLENHVFITSALYGVVPALSPMAPHRLDFLMKLKVAGKTLKSHWKAVYDEALKKEEVIFSLLSSEFETVFSKEIRAKMVTFKFMEDRGGQLKIHSTISKKARGAFLTALIENQVQTVGEARRLNFAGFVYREDLSQPQGLVFVKEV
>NC_021003.1|WP_000508269.1|474471_474636_-|YczI-family-protein
MGFYLMVASMLLGLLALKIGFSQFKEKKDKFLSILTSLAGTALVLVAVWLGWPK
>NC_021003.1|WP_000822864.1|474802_476398_-|hypothetical-protein
MKRIVFELIFIATTWYIFLPPLNLTSWEFLFFLCGHLLVVAILFGFGKGINLVKTVHVRHGKAEAALNLEGFKINRLGKILLASIGGILLLAALVSLVTSSMFQAKNYANVVTVTEKDFTEFPKSDTSKVPILDRSTAEKIGDRYLGSLTDKVSQYVAADTYTQLTIDGKPYRVTPLEYADPIKWFNNQAKGIGEYIKVDMVTGNADLVDLKTPIKYSDSEYFNRDVKRHLRLKYPTKIFKTPSFEVDDEGNPFYVATVYQKQFGLAVPRPASVIILDATNGETKEYSLSDVPEWVDRIYPAEETIEQINYNGKYKDGFLNAMISKKNVTQTTNGYNYLSIGNDIYLYTGVTSANADESNLGFILENMRTGEITKYSLASATEESARESAEGAVQEKSYKATFPILINLNDKPLYIMGLKDNAGLVKEYALVDAVEYQNVIVATTVEEMLSKYANKNDLEIDNATTESIKGVVADLKSAVIKGDTVYFFKVDGKIYKVKASVSDDLPYLENGKTFEGQVGKDNYLKTFKVQ
>NC_021003.1|WP_000412213.1|476409_476820_-|peptide-deformylase
MEKKIVKDILFLSQVSHPASQEDLYLARDLQDTLLANRDTCVGLAANMIGMQKRVIIFNLGLVPVVMFNPVLLSFEGSYEAEEGCLSLVGVRSTKRYETIRLAYRDSKWQEQTITLTGFPAQICQHELDHLEGRII
>NC_021003.1|WP_001277403.1|476935_477727_-|glutathione-dependent-disulfide-bond-oxidoreductase
MSAYQLPTVWQDEASNQGAFTGLNRPTAGARFEQNLPKGEQAFQLYSLGTPNGVKVTILLEELLEAGFKEAAYDLYKIAIMDGDQFGSDFVKLNPNSKIPALLDQSGTENVRVFESAHILLYLAEKFGAFLPSNPVEKVEVLNWLFWQAGAAPFLGGGFGHFFNYAPEKLEYPINRFTMEVKRQLDLLDKELAQKPYIAGNDYTIADIAIWSWYGQLVQGNLYQGSAKFLDASSYQNLVKWAEKIANRPAVKRGLEVTYTEIK
>NC_021003.1|WP_000032458.1|477739_480436_-|cation-translocating-P-type-ATPase
MSKEQKRQAFYTQSPEEVLQAVDATEQGLSSSEAEKRLAEFGHNELEEGEKRSILVKFIEQFKDLMIIILVAAAILSVVTSGGEDIADAIIILAVVIINAAFGVYQEGKAEEAIEALKSMSSPVARVLRDGHMAEIDSKELVPGDIVALEAGDVVPADLRLIEANSLKIEEAALTGESVPVEKDLSVELATDAGIGDRVNMAFQNSNVTYGRGMGVVVNTGMYTEVGHIAGMLQDADETDTPLKQNLNNLSKVLTYAILVIALVTFVVGVFIQGKNPLGELLTSVALAVAAIPEGLPAIVTIVLSLGTQVLAKRHSIVRKLPAVETLGSTEIIASDKTGTLTMNKMTVEKVFYDAVLHDSADDIELGLEMPLLRSVVLANDTKIDVEGNLIGDPTETAFIQYALDKGYDVKGFLEKYPRVAELPFDSDRKLMSTVHPLPDGRFLVAVKGAPDQLLKRCLLRDKAGDIAPIDEKVTNLIHTNNSEMAHQALRVLAGAYKIIDSIPENLTSEELENDLIFTGLIGMIDPERPEAAEAVRVAKEAGIRPIMITGDHQDTAEAIAKRLGIIDANDTEGHVLTGAELNELSDEEFEKVVGQYSVYARVSPEHKVRIVKAWQKQGKVVAMTGDGVNDAPALKTADIGIGMGITGTEVSKGASDMILADDNFATIIVAVEEGRKVFSNIQKTIQYLLSANTAEVLTIFLSTLFGWDVLQPVHLLWINLVTDTFPAIALGVEPAEPGVMNHKPRGRKASFFSGGVLSSIIYQGVLQAALVMSVYGLAIAYPVHVGDNHAIHADALTMAFATLGLIQLFHAYNVKSVYQSILTVGPFKSKTFNWSILVSFILLMATIVVEPLEGIFHVTKLDLSQWGIVMAGSFSMIIIVEIVKFIQRKLGFDKNAI
>NC_021003.1|WP_000813919.1|480739_481924_+|CDF-family-manganese-efflux-transporter-MntE
MKQSISNLKLAERGAIISISTYLILSAAKLAAGHLLHSSSLVADGFNNVSDIIGNVALLIGIRMARQPADRDHRFGHWKIEDLASLITSIIMFYVGFDVLRDTIQKILSREETVIDPLGATLGIISAAIMFVVYLYNTRLSKKSNSKALKAAAKDNLSDAVTSLGTAIAILASSFNYPIVDKLVAIIITFFILKTAYDIFIESSFSLSDGFDDRLLEDYQKAIMEIPKISKVKSQRGRTYGSNIYLDITLEMNPDLSVFESHEIADQVESMLEERFGVFDTDVHIEPAPISEDEILDNVYKKLLMREQLIDQGNQLEELLTDDFVYIRQDGEQMDKEAYKTKKELNSAIKDIQITSISQKTKLICYELDGIIHTSIWRRHETWQNIFHQETKKE
>NC_021003.1|WP_001279136.1|482066_483938_-|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MSDFIVEKLSKSVGDKTVFRDISFIIHDLDRIGLIGVNGTGKTTLLDVLSGVSGFDGDVSPFSAKNDYQIGYLTQDPDFDDRKTVLDTVLSSELKEIQLIREYELIMLDYSEDKQARLERVMAEMDSLQAWEIESQVKTVLSKLGIQDLSTPVGELSGGLRRRVQLAQVLLGNHDLLLLDEPTNHLDIAIIEWLTLFLKNSKKTVLFITHDRYFLDALSTRIFELDRAGLTEYQGNYQDYVRLKAEQDERDAALLHKKEQLYKQELAWMRRQPQARATKQQARINRFHDLKKEVSGSSAETDLTMNFETSRIGKKVIEFQAVSFAYENKPILQDFNLLVQAKDRIGIVGDNGVGKSTLLNLIAGSLEPTKGQVVIGETVRIAYFSQQIEGLDESKRVINYLQEVAEEVKTSGGSTTSIAELLEQFLFPRSTHGTLIEKLSGGEKKRLYLLKLLLEKPNVLLLDEPTNDLDIATLTVLENFLQGFAGPVLTVSHDRYFLDKVATKILAFEDSKIRPFFGHYTDYLDEKAFETDMANQVQKVEKEKVVKVREDKKRMTYQEKQEWASIEGDIETLEKRIAAIEEEMQANGSDFGKLATLQKELDEKNEALLEKYERYEYLSEFDS
>NC_021003.1|WP_001138808.1|483934_485119_-|CCA-tRNA-nucleotidyltransferase
MPSEFQKALPVLEKIKEAGFEAYFVGGSVRDALLHSPIHDVDIATSSYPEETKQIFPRTADIGIEHGTVLVLDGDEEYEVTTFRTEDVYVDYRRPSAVSFVRSLEEDLKRRDFTVNAFALDETGEIVDLFHGLEDLEKQVLRAVGVASERFNEDALRIMRGFRFQASLGFALEPETFKAMKTLTPLLEKISVERTFVEFDKLLLAPFWRRGLASMIESQAYDYLPDMASSQDKLNRLFDLETDFTFESSEQAWAALLWALEIENAQSFLKSWKTSRQFAKQVQDLLIILALRENGELSKRDCYRFDIDLLLQAENLRQAQGKEVNPQAITEKYQSLTIHDKKEIQINGDILIKEYGYQPGPDLGEILTEIEFAIVDGELENNREAIHAYLREKK

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Crispr_ID: NC_021003_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021003_2

1259970-1260065

Orphan

Consensus_repeat	Method
AATGTGTAAGATTTTTATATATAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021003_2

>merge|NC_021003|2|1259970-1260065|CRISPRCasFinder
AATGTGTAAGATTTTTATATATAATTTTTCTACACATACATTGTACATCTAAAAGAAAGCCCTGTCAAGAGAAATGTGTAAAATTTTTATATATAA

>NC_021003|2|2|1259970-1260065|CRISPRCasFinder
AATGTGTAAGATTTTTATATATAA	TTTTTCTACACATACATTGTACATCTAAAAGAAAGCCCTGTCAAGAGA
AATGTGTAAAATTTTTATATATAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_021003.1\|WP_000744903.1\|1260090_1261257_-\|CynX/NimT-family-MFS-transporter	unknown	unknown	gnl\|CDD\|340897
NC_021003.1\|WP_000200890.1\|1264764_1265397_-\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|319798
NC_021003.1\|WP_000800407.1\|1253227_1254703_+\|DUF3502-domain-containing-protein	unknown	unknown	gnl\|CDD\|378792
NC_021003.1\|WP_000273864.1\|1259625_1259952_-\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NC_021003.1\|WP_001233696.1\|1258141_1259053_-\|DUF4097-domain-containing-protein	unknown	unknown	gnl\|CDD\|372574
NC_021003.1\|WP_000148252.1\|1250588_1250939_+\|hypothetical-protein	unknown	unknown	unknown
NC_021003.1\|WP_000714582.1\|1251257_1252187_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226666
NC_021003.1\|WP_000096213.1\|1261314_1262454_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133016
NC_021003.1\|WP_000915346.1\|1269165_1269504_+\|peptidase-C39	unknown	unknown	gnl\|CDD\|239099
NC_021003.1\|WP_000836451.1\|1267212_1267785_+\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|212030
NC_021003.1\|WP_000838912.1\|1266299_1266971_-\|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-beta	unknown	unknown	gnl\|CDD\|224674
NC_021003.1\|WP_001140336.1\|1256082_1256943_+\|DUF4299-domain-containing-protein	unknown	unknown	gnl\|CDD\|339103
NC_021003.1\|WP_000500040.1\|1265418_1266291_-\|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-alpha	unknown	unknown	gnl\|CDD\|129801
NC_021003.1\|WP_000424431.1\|1269481_1269841_+\|hypothetical-protein	unknown	unknown	unknown
NC_021003.1\|WP_001075102.1\|1252200_1253124_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_021003.1\|WP_001035707.1\|1262521_1264372_+\|polysaccharide-biosynthesis-protein	unknown	unknown	gnl\|CDD\|224011
NC_021003.1\|WP_001268172.1\|1267836_1268700_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NC_021003.1\|WP_001030031.1\|1254974_1255961_+\|rhodanese-related-sulfurtransferase	unknown	unknown	gnl\|CDD\|234663
NC_021003.1\|WP_000198697.1\|1259045_1259639_-\|DUF1700-domain-containing-protein	unknown	unknown	gnl\|CDD\|227053
NC_021003.1\|WP_000808456.1\|1257014_1258079_-\|membrane-protein	unknown	unknown	gnl\|CDD\|370966

Protein	Function_ID	Function_description	E-value
NC_021003.1\|WP_000744903.1\|1260090_1261257_-\|CynX/NimT-family-MFS-transporter	gnl\|CDD\|340897	cd17339, MFS_NIMT_CynX_like, 2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.00309e-125
NC_021003.1\|WP_000200890.1\|1264764_1265397_-\|HAD-family-hydrolase	gnl\|CDD\|319798	cd04302, HAD_5NT, haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to the Pseudomonas aeruginosa PA0065. 5'-nucleotidases dephosphorylate nucleoside 5'-monophosphates to nucleosides and inorganic phosphate. Purified Pseudomonas aeruginosa PA0065 displayed high activity toward 5'-UMP and 5'-IMP, significant activity against 5'-XMP and 5'-TMP, and low activity against 5'-CMP. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	8.29103e-98
NC_021003.1\|WP_000800407.1\|1253227_1254703_+\|DUF3502-domain-containing-protein	gnl\|CDD\|378792	pfam12010, DUF3502, Domain of unknown function (DUF3502). This presumed domain is functionally uncharacterized. This domain is found in bacteria. This domain is about 140 amino acids in length. This domain is found associated with pfam01547.	4.24398e-44
NC_021003.1\|WP_000273864.1\|1259625_1259952_-\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	3.12912e-19
NC_021003.1\|WP_001233696.1\|1258141_1259053_-\|DUF4097-domain-containing-protein	gnl\|CDD\|372574	pfam13349, DUF4097, Putative adhesin. This has a putative all-beta structure with a twenty-residue repeat with a highly conserved repeating GD, gly-asp, motif. It may form part of a bacterial adhesin.	9.9455e-40
NC_021003.1\|WP_000714582.1\|1251257_1252187_+\|sugar-ABC-transporter-permease	gnl\|CDD\|226666	COG4209, LplB, ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism].	3.01638e-143
NC_021003.1\|WP_000096213.1\|1261314_1262454_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|133016	cd02525, Succinoglycan_BP_ExoA, ExoA is involved in the biosynthesis of succinoglycan. Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.	9.65723e-108
NC_021003.1\|WP_000915346.1\|1269165_1269504_+\|peptidase-C39	gnl\|CDD\|239099	cd02418, Peptidase_C39B, A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage is mediated by the transporter as part of the secretion process. Bacteriocins are antibiotic proteins secreted by some species of bacteria that inhibit the growth of other bacterial species. The bacteriocin is synthesized as a precursor with an N-terminal leader peptide, and processing involves removal of the leader peptide by cleavage at a Gly-Gly bond, followed by translocation of the mature bacteriocin across the cytoplasmic membrane. Most endopeptidases of family C39 are N-terminal domains in larger proteins (ABC transporters) that serve both functions. The proposed protease active site is conserved in this sub-family.	5.05637e-28
NC_021003.1\|WP_000836451.1\|1267212_1267785_+\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|212030	cd00118, LysM, Lysin Motif is a small domain involved in binding peptidoglycan. LysM, a small globular domain with approximately 40 amino acids, is a widespread protein module involved in binding peptidoglycan in bacteria and chitin in eukaryotes. The domain was originally identified in enzymes that degrade bacterial cell walls, but proteins involved in many other biological functions also contain this domain. It has been reported that the LysM domain functions as a signal for specific plant-bacteria recognition in bacterial pathogenesis. Many of these enzymes are modular and are composed of catalytic units linked to one or several repeats of LysM domains. LysM domains are found in bacteria and eukaryotes.	5.58739e-13
NC_021003.1\|WP_000838912.1\|1266299_1266971_-\|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-beta	gnl\|CDD\|224674	COG1760, SdaA, L-serine deaminase [Amino acid transport and metabolism].	1.1908e-89
NC_021003.1\|WP_001140336.1\|1256082_1256943_+\|DUF4299-domain-containing-protein	gnl\|CDD\|339103	pfam14132, DUF4299, Domain of unknown function (DUF4299). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 275 and 313 amino acids in length. There are two conserved sequence motifs: RGF and DAY. There are two completely conserved residues (P and D) that may be functionally important.	1.22402e-120
NC_021003.1\|WP_000500040.1\|1265418_1266291_-\|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-alpha	gnl\|CDD\|129801	TIGR00718, Probable_L-serine_dehydratase_alpha_chain, L-serine dehydratase, iron-sulfur-dependent, alpha subunit. This enzyme is also called serine deaminase. L-serine dehydratase converts serine into pyruvate in the gluconeogenesis pathway from serine. This model describes the alpha chain of an iron-sulfur-dependent L-serine dehydratase, found in Bacillus subtilis. A fairly deep split in a UPGMA tree separates members of this family of alpha chains from the homologous region of single chain forms such as found in Escherichia coli. This family of enzymes is not homologous to the pyridoxal phosphate-dependent threonine deaminases and eukaryotic serine deaminases. [Energy metabolism, Amino acids and amines, Energy metabolism, Glycolysis/gluconeogenesis].	1.44295e-105
NC_021003.1\|WP_001075102.1\|1252200_1253124_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	5.04007e-69
NC_021003.1\|WP_001035707.1\|1262521_1264372_+\|polysaccharide-biosynthesis-protein	gnl\|CDD\|224011	COG1086, COG1086, Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism].	0
NC_021003.1\|WP_001268172.1\|1267836_1268700_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	7.85625e-10
NC_021003.1\|WP_001030031.1\|1254974_1255961_+\|rhodanese-related-sulfurtransferase	gnl\|CDD\|234663	PRK00142, PRK00142, rhodanese-related sulfurtransferase.	0
NC_021003.1\|WP_000198697.1\|1259045_1259639_-\|DUF1700-domain-containing-protein	gnl\|CDD\|227053	COG4709, COG4709, Predicted membrane protein [Function unknown].	7.13921e-64
NC_021003.1\|WP_000808456.1\|1257014_1258079_-\|membrane-protein	gnl\|CDD\|370966	pfam10310, DUF5427, Family of unknown function (DUF5427). This is a domain of unknown function. Family members found in Saccharomyces cerevisiae, are synthetic lethal with genes involved in maintenance of telomere capping. However, experimental evidence is yet to verify the exact function of family members and the domain.	5.27948e-06

>NC_021003.1|WP_000273864.1|1259625_1259952_-|PadR-family-transcriptional-regulator
MYFPTSSALIEFLILAVLEQGDSYGYEISQTIKLIANIKESTLYPILKKLEGNSFLTTYSREFQGRMRKYYSLTNGGIEQLLTLKDEWTLYTDTINGIIEGSIRHDKN
>NC_021003.1|WP_000198697.1|1259045_1259639_-|DUF1700-domain-containing-protein
MTRTEYLTQLELYLKKLPEADRIEAMDYFRELFDDAGVEGEEELIASLGTPKEVAHEVLSNLLDKKINEAPAQKNNRQILHIALLALLAAPIGIPLGIAILVTLFAILVAALTVILAFFAVSILGIIGGFLFLVESFTVLAQAKSAFILIFGSGLLAIGASSLVLLGISYVARFFGLLIVRLVQFVLKKGKRGNQHA
>NC_021003.1|WP_001233696.1|1258141_1259053_-|DUF4097-domain-containing-protein
MRKWTKGFLIFGVVTTVIGFILLFVGIQSDGIKSLLSMSKEPVYDSRTEKLTFGKEVENLEITLHQHTLTITDSFDDQIHISYHPSLSAHHDLITNQNDRTLSLTDKKLSETPFLSSGIGGILHIASSYSSRFEEVILRLPKGRTLKGINISANRGQTTIINASLENATLNTNSYILRIEGSRIKNSKLTTPNIVNIFDTVLTDSQLESTENHFHAENIQVHGKVELTAKDYLRIILDQKESQRINWDISSNYGSIFQFTREKPESRGTELSNPYKTEKTDVKDQLIARSDDNIDLISTPSRR
>NC_021003.1|WP_000808456.1|1257014_1258079_-|membrane-protein
MKQEWFESNDFVKTTSKNKPEEQAQEVADKAEETIADLDTPIGKNTQVEEEVSQAEVELESQQEEKIETPEGGEARTEIEEKKASNSTEEEPDLSKETEKVTIAEESQEALPQQKATTKEPLLISKSLESPYIPDQAPKSRDKWKEQVLDFWSWLVEAIKSPTSKLETSITHSYTAFLLLILFSASSFFFSIYHIKHAYYGHIASINSRFPEQLAPLTLFSIISILVATTLFFFSFLLGSFVVRRFIHQEKDWTLDKVLQQYSQLLAIPIFLTAIASFFAFFDSLRFTALLCVISIGIILLASLHIITRPSQASETDSFYQLFLSVLVNGVIILLFFVAEVALIGDYLRILAFL
>NC_021003.1|WP_001140336.1|1256082_1256943_+|DUF4299-domain-containing-protein
MAKTFFIPNKQSILGEQEILNAKSILALLDGLESHIYDVVYLRQPLNRLEYIECAIVGQSQFLFKVSYADGQKAYRVDLPDLLTETDWQIIKSFLDALLAYTGTDIEGLDGFDFEAYFQASIQAYLADPVARFTICQGIFNPIFFSRENLKSFLEADGLAQFEARVRAVQETDAYFARVSFYQDGEGKVHGVYHLAQGVKTVLPREPFVPAAYIEQLVDKEVQWEIDLVQITGDGSKPEDYEAIARLDYAKFLEVLPPSFYHQLDANQIEVQPILDKDFKTLAQEK
>NC_021003.1|WP_001030031.1|1254974_1255961_+|rhodanese-related-sulfurtransferase
MAKDIRVLLYYLYTPIENAEQFAADHLAFCKSIGLKGRILVADEGINGTVSGDYETTQKYMDYVHSLPGMEELWFKIDEENEQAFKKMFVRYKKEIVHLGLEDNDFDNDINPLETTGAYLSPKEFKEALLDKDTVVLDTRNDYEYDLGHFRGAIRPDIRNFRELPQWVRDNKEKFMDKRVVVYCTGGVRCEKFSGWMVREGYKDVGQLHGGIATYGKDPEVQGELWDGKMYVFDERIAVDVNHVNPTIVGKDWFDGTPCERYVNCGNPFCNRRILTSEENEDKYLRGCSHECRVHPRNRYVSKNELTQAEVIERLAAIGESLDQAATV
>NC_021003.1|WP_000800407.1|1253227_1254703_+|DUF3502-domain-containing-protein
MKNWKKYAFASASVVALAAGLAACGNLTGNSKKAADSGDKPVIKMYQIGDKPDNLDELLANANKIIEEKVGAKLDIQYLGWGDYGKKMSVITSSGENYDIAFADNYIVNAQKGAYADLTELYKKEGKDLYKALDPAYIKGNTVNGKIYAVPVAANVASSQNFAFNGTLLAKYGIDISGVTSYETLEPVLKQIKEKAPDVVPFAIGKVFIPSDNFDYPVANGLPFVIDLEGDTTKVVNRYEVPRFKEHLKTLHKFYEAGYIPKDVATSDTSFDLQQDTWFVREETVGPADYGNSLLSRVANKDIQIKPITNFIKKNQTTQVANFVISNNSKNKEKSMEILNLLNTNPELLNGLVYGPEGKNWEKIEGKENRVRVLDGYKGNTHMGGWNTGNNWILYINENVTDQQIENSKKELAEAKESPALGFIFNTDNVKSEISAIANTMQQFDTAINTGTVDPDKAIPELMEKLKSEGAYEKVLNEMQKQYDEFLKNKK
>NC_021003.1|WP_001075102.1|1252200_1253124_+|carbohydrate-ABC-transporter-permease
MAKKKIKKEKIDNVGIHSFSKKADIFFSIISGLIALSCILPFVFVIIISVTDEKSLLQYGYSFFPSQFGLDGFEFLAQFKDKILQALFISVFVTVVGTLTNVFITTTYAYAISRTTFKYRRFFTIFVLLSMLFNAGLVPGYIMVTRVLQLGDTVWALIVPMLLSPFNIILMRSFFKKTIPEAILESARIDGASEARIFFQICLPLSLPGIATITLLTALGFWNDWFNALLYIKSDNLYPLQYLLMQIQQNMDYIAKAVGLTGQLGVALPKETGRMAMVVVATLPIAILYPFFQRYFVKGLTIGGVKE
>NC_021003.1|WP_000714582.1|1251257_1252187_+|sugar-ABC-transporter-permease
MKKFSKTLRDNWIFLLMVLPGALWLILFFYIPVFGNVVAFKDYHMTSNGFIDSIINSKWVGLDNFRFLFSSRDAFIITRNTVLYNLGFIFLGLVVSVGIAIILSELRSKRMVKIFQTSMLFPYFLSWVIISFFTDAFLNIDKGVFNHLLESLGLKEVNFYADLGIWPYLLLFLGIWKGFGYSSVMYYATIMGIDPTYYEAATVDGASKWQRIRNVTIPQLTPLVTVLTILAVGNIFRADFGLFYQIPHNAGQLYNVTNVLDVYVFNGLTQTADIGMAAAAGLYQSVVGLILVILSNLLARRVDPNSALF
>NC_021003.1|WP_000148252.1|1250588_1250939_+|hypothetical-protein
MTGVSNPTTDSARLVLAEAKKAFADDSLTEQGLRDILQTVKDAIASLESIKESQSATKDGGQTAGKETADKDVLENSQEELQKAVLFLADEKGSEHTEAELIDNLKEVIAKLKANA
>NC_021003.1|WP_000744903.1|1260090_1261257_-|CynX/NimT-family-MFS-transporter
MKKQSLFFVPGIILIGVSLRTPFTVLPIILGNISQGLEVEVSSLGVLTSLPLLMFTLFSPFSTRLAQKIGLEHLFTYSLFFLTIGSLIRLINLPLLYLGTLMVGASVAVINVLLPSLIQANQPKKIGFLTTLYVTSMGIATALASYLAVPITQASSWKGLILLLTLLCLATFLVWLPNHRYNHRLAPQTKQKSQIKVMRNKQVWAIIIFSGFQSLIFYTAMTWLPTMSIHAGLSSHEAGLLTSILSLISIPFSMTIPSLTTSLSTRNRQLMLTLVSLAGVVGISMLFFPINNFIYWLAIHLLIGTATSALFPYLMVNFSLKTSAPEKTAQLSGLSQTGGYILAAFGPTLFGYSFDLFHSWVPAVAALLLIDILMTVALFTVDRADKIL
>NC_021003.1|WP_000096213.1|1261314_1262454_+|glycosyltransferase-family-2-protein
MSSKVSGFQDKNGKVLKIMIEWWKGKFRRVVVTQNVESLLVSIVISAYNEEKYLPGLIEDLKNQTYPKENIEILFINAMSTDGTTAIIQQFIKEDAEFNSIRLYNNPKKNQASGFNLGVKHSVGGLILKIDAHSKVTESFVMNNVAVIQQGEFVCGGPRPTIVKGKGKWAETLHLVEENMFGSSIANYRNSSEDRYVSSIFHGMYKREVFQKVGLVNEQLGRTEDNDIHYRIREHGYKIRYSPSILSYQYIRPTFKKMLHQKYSNGLWIGLTSHVQFKCLSLFHYVPCLFVLSLVFSLALLPITFVFITLLLGAYFLLLSLLSLLTLLTLLKHKNGFLIVMPFLLFSIHFAYGLGTIVGLIRGFKWKKEYKGTVIYLEK
>NC_021003.1|WP_001035707.1|1262521_1264372_+|polysaccharide-biosynthesis-protein
MNKKLTDYVIDLVEILNKQQKQVFWGIFDIFSMVVSIIVSYILFYGLINPAPVDYIIYTSLAFLFYQLMVDFWGLSASISRYSKITDFMKIFFGVTASSVLSYSICYAFLPLFSIRFIILFILLSTFLILLPRITWQLIYSRRKKGSGDGEHRRTFLIGAGDGGALFMDSYQHPTSELELVGILDKDSKKKGQKLGGIPVLGSYDNLPELAKRHQIERVIVAIPSLDPSEYERILQMCNKLGVKCYKMPKVETVVQGLHQAGTGFQKIDITDLLGRQEIRLDESRLGAELTGKTILVTGAGGSIGSEICRQVSRFNPERIVLLGHGENSIYLVYHELIRKFQGIDYVPVIADIQDYDRLLQVFEQYKPAIVYHAAAHKHVPMMERNPKEAFKNNIRGTYNVARAVDEAKVPKMVMISTDKAVNPPNVMGATKRVAELIVTGFNQRSQSTYCAVRFGNVLGSRGSVIPVFERQIAEGGPVTVTDFRMTRYFMTIPEASRLVIHAGAYAKDGEVFILDMGKPVKIYDLAKKMVLLSGHTESEIPIVEVGIRPGEKLYEELLVSTELVDNQVMDKIFVGKVNVMPLESINQKIGEFRTLSGDELKQAIIAFANQTTHIE
>NC_021003.1|WP_000200890.1|1264764_1265397_-|HAD-family-hydrolase
MTSITAIFFDLDGTLVDSSIGIHNAFTYTFKELGVPSPDAKTIRGFMGPPLESSFATCLSKDQISEAMQIYRSYYKAKGIYEAQLFPQIIDLLEELSSSYPLYITTTKNTSTAQDMAKNLEIHHFFDGIYGSSPEAPHKADVIHQALQTHQLAPEQAIIIGDTKFDMLGARETGIQKLAVTWGFGEQADLLNYQPDYIAHKPLEVLAYFQ
>NC_021003.1|WP_000500040.1|1265418_1266291_-|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-alpha
MFYSIKELVEQADLDFQGNVAELMITTEFELTGREREEVFLLMERNLEVMKASVQLGLNENKSRSGLTGGDAAKLDHYIKNEKTLSDYTILSAARNAIAVNEHNAKMGLVCATPTAGSAGCLPSVLTAAIEKLDLSHEQQLDFLFAAGAFGLVIANNASISGAEGGCQAEVGSASAMSAAALTLAAGGTPYQASQAIAFVIKNMLGLICDPVAGLVEVPCVKRNAMGASFAFIAADMALAGIESKIPVDEVIDAMYQVGASMPTAFRETAEGGLATTPTGRRLQKEIFGE
>NC_021003.1|WP_000838912.1|1266299_1266971_-|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-beta
MKSLRFQSVFDIIGPVMIGPSSSHTAGAVRIGKIVSSIFDDTPTEVEFQLFNSFAKTYRGHGTDLALVAGILGMDTDDPEIPNSLEIAHKRGIKIVWTIQKDSNAPHPNTTKITVKNAHKTISVTGISIGGGNIQVTELNGFAVSLNMNTPTIIIVHQDIPGMIALVTEALSRYGINIAQMNVTREKAGEKAIMIIEVDSRNCDEAIEEIRKIPHLHNVNFFK
>NC_021003.1|WP_000836451.1|1267212_1267785_+|LysM-peptidoglycan-binding-domain-containing-protein
MKSITKKIKATLAGVAALFAVFSPSFVSAQESSTYTVKEGDTLSEIAETHNTTVEKLAENNHIDNIHLIYVDQELVIDGPVAPVATPAPATYAAPAAQDETVSAPVVSETVVSTVSGSEAEAKEWIAQKESGGSYTATNGRYIGRYQLTDSYLNGDYSAENQERVADAYVAGRYGSWTAAKNFWLNNGWY
>NC_021003.1|WP_001268172.1|1267836_1268700_-|helix-turn-helix-transcriptional-regulator
MRYDFGKVYKEIRESKGLTQEEVCGGVLSRTSLSKIESGKTTPKYENMEFLLRQINMSFEEFEYICQLYQPSQRTEIMQTYLNMRSIIGTSDLVNLFQKCQDYLKTHHDLPIEEIRDMLEVVIYLRQHGAGELSKHAEQVVKKLWKKIEKQDTWYESDLKILNTILFSFPIEYLHLITGKILQRLEVYKNYQHLYDLRMTILLNLSTLYLYNQDKNMCKQICYTLLEDAKNKKSYDRLAICYVRIGICTDDSKLIQKGFSLLELTEETSMLSHLKKEVEIYYQAKER
>NC_021003.1|WP_000915346.1|1269165_1269504_+|peptidase-C39
MLKKYPCTMQHDQSDCAAAVVSTVLLSYKKELSIMKIREIIGTDMYGTTVSGIVSGLNKLNFTVKAVRVALEDLTPKLTFPAILQVKNDLGQNHFVVLHSIKEKINGTRITK
>NC_021003.1|WP_000424431.1|1269481_1269841_+|hypothetical-protein
MELVLPNNYVVIDEEEMMYLDGGAIYIPRWAITGAITGAAYAALAAAGGGGLQLVLASYGLRSALVAGIVKGLGVLGIHIGNAFANTVIRSIASAGIGAGADWILPILLMAGMGDVIIN

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

229729 : 278604

Indivirus(20.0%)

protease,holin,transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000411210.1\|229729_230599_-\|holin	choline kinase LicA	NA	NA	NA	NA
WP_000609887.1\|230615_231638_-	alcohol dehydrogenase catalytic domain-containing protein	NA	NA	NA	NA
WP_000638507.1\|231642_232350_-	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	NA	NA	NA	NA
WP_000835913.1\|232685_234173_+	type IV teichoic acid flippase TacF	NA	NA	NA	NA
WP_000812001.1\|234182_234986_+\|holin	phosphorylcholine transferase LicD	A0A1V0SD50	Indivirus	9.0e-10	27.1
WP_001199647.1\|234987_235797_+\|holin	phosphorylcholine transferase LicD	A0A1V0SD50	Indivirus	3.5e-09	29.5
WP_001126426.1\|236071_239248_-	carbamoyl-phosphate synthase large subunit	NA	NA	NA	NA
WP_000166701.1\|239559_240639_-	glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit	R4TGJ8	Halovirus	6.3e-59	35.9
WP_001293836.1\|240688_241612_-	aspartate carbamoyltransferase catalytic subunit	M1HGA5	Paramecium_bursaria_Chlorella_virus	3.0e-25	31.7
WP_000850024.1\|241630_242152_-	bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR	NA	NA	NA	NA
WP_000244451.1\|242362_242992_-	endonuclease III	NA	NA	NA	NA
WP_000773234.1\|242991_243534_-	DUF177 domain-containing protein	NA	NA	NA	NA
WP_001818871.1\|243712_244030_+	hypothetical protein	NA	NA	NA	NA
WP_001818872.1\|244268_245828_+	ABC-F family ATP-binding cassette domain-containing protein	A0A1B0RXA0	Streptococcus_phage	9.3e-11	27.5
WP_000895734.1\|245871_246771_-\|protease	zinc metalloprotease HtpX	NA	NA	NA	NA
WP_000219824.1\|246772_247333_-	LemA family protein	NA	NA	NA	NA
WP_000802934.1\|247426_248140_+	16S rRNA (guanine(527)-N(7))-methyltransferase RsmG	NA	NA	NA	NA
WP_001813450.1\|248442_249726_+	uracil transporter	Q9KX94	Enterobacteria_phage	3.1e-60	35.3
WP_000863628.1\|249920_251492_-	signal recognition particle protein	NA	NA	NA	NA
WP_000402066.1\|251503_251836_-	putative DNA-binding protein	NA	NA	NA	NA
WP_000702355.1\|251926_252304_-	DUF1934 domain-containing protein	NA	NA	NA	NA
WP_001003509.1\|252375_253680_+	HD domain-containing protein	E3T4P8	Cafeteria_roenbergensis_virus	2.3e-26	29.8
WP_000023522.1\|253692_254499_+	sugar-phosphatase	NA	NA	NA	NA
WP_001009000.1\|254541_255540_+	SAP domain-containing protein	NA	NA	NA	NA
WP_001068669.1\|255820_256168_-	50S ribosomal protein L19	NA	NA	NA	NA
WP_000237416.1\|256286_256616_-	fluoride efflux transporter CrcB	A0A2H4PQR0	Staphylococcus_phage	6.3e-10	37.8
WP_000712094.1\|256609_256984_-	fluoride efflux transporter CrcB	NA	NA	NA	NA
WP_000362441.1\|256980_257247_-	chorismate mutase	NA	NA	NA	NA
WP_001162128.1\|257362_257806_-	flavodoxin	NA	NA	NA	NA
WP_000401798.1\|257909_258845_+	bifunctional oligoribonuclease/PAP phosphatase NrnA	NA	NA	NA	NA
WP_001808393.1\|258898_259183_+	type B 50S ribosomal protein L31	NA	NA	NA	NA
WP_001818873.1\|259239_259458_-	hypothetical protein	NA	NA	NA	NA
WP_000199560.1\|260527_261874_+	NADP-specific glutamate dehydrogenase	NA	NA	NA	NA
WP_000711939.1\|262379_262550_-	hypothetical protein	NA	NA	NA	NA
WP_000424223.1\|264902_265352_-	YhcH/YjgK/YiaL family protein	NA	NA	NA	NA
WP_001000318.1\|265856_266312_-	HIT domain-containing protein	NA	NA	NA	NA
WP_000272434.1\|266333_267794_-	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_000239901.1\|267853_269431_-	extracellular solute-binding protein	NA	NA	NA	NA
WP_001180441.1\|269499_270939_-	hypothetical protein	NA	NA	NA	NA
WP_001155321.1\|271294_272248_+\|transposase	IS30-like element ISSpn8 family transposase	H7BWC8	unidentified_phage	1.6e-34	35.2
WP_001071049.1\|273137_274070_-	sugar ABC transporter permease	NA	NA	NA	NA
WP_000448315.1\|274070_274757_-	N-acetylmannosamine-6-phosphate 2-epimerase	NA	NA	NA	NA
WP_078101602.1\|275473_276232_-	MurR/RpiR family transcriptional regulator	NA	NA	NA	NA
WP_001165928.1\|276409_277018_+	DUF624 domain-containing protein	NA	NA	NA	NA
WP_088782213.1\|277252_278604_-\|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	5.9e-62	50.9

DBSCAN-SWA_2

373963 : 418003

Streptococcus_phage(20.0%)

holin,tRNA,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_171800965.1\|373963_374365_-\|transposase	transposase	A0A218MNE7	uncultured_virus	6.7e-06	25.6
WP_000484480.1\|374372_374678_-\|transposase	IS66 family transposase zinc-finger binding domain-containing protein	NA	NA	NA	NA
WP_000691852.1\|374664_374859_-\|transposase	transposase	NA	NA	NA	NA
WP_001136122.1\|375255_375441_-	hypothetical protein	NA	NA	NA	NA
WP_000065723.1\|375744_377307_-	glutamine-hydrolyzing GMP synthase	A0A1V0SH76	Hokovirus	1.4e-19	32.8
WP_000936188.1\|377448_378147_+	GntR family transcriptional regulator	NA	NA	NA	NA
WP_000071668.1\|378189_379086_-	EamA family transporter	NA	NA	NA	NA
WP_000872215.1\|379094_380030_-	serine hydrolase	NA	NA	NA	NA
WP_001102216.1\|380026_380752_-	proteinase	NA	NA	NA	NA
WP_000290649.1\|380835_381471_-\|holin	1-alkyl-2-acetylglycerophosphocholine esterase	A0A2K9L661	Tupanvirus	4.3e-07	28.2
WP_000972923.1\|381472_382300_-	Cof-type HAD-IIB family hydrolase	NA	NA	NA	NA
WP_001843873.1\|382658_383375_-	CapA family protein	A0A0N9SJ77	Staphylococcus_phage	3.2e-27	32.0
WP_001272942.1\|383897_384509_+	peptide deformylase	E3SLL2	Synechococcus_phage	3.8e-16	42.4
WP_000855749.1\|384553_385282_+	23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB	NA	NA	NA	NA
WP_000272302.1\|385320_386232_-	thioredoxin-disulfide reductase	G3MA85	Bacillus_virus	4.5e-90	51.8
WP_000926600.1\|386297_386522_-	DUF4059 family protein	NA	NA	NA	NA
WP_000590987.1\|386599_387343_-	amino acid ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.6e-29	41.0
WP_001103449.1\|387342_388143_-	amino acid ABC transporter permease	NA	NA	NA	NA
WP_000889093.1\|388300_388657_-	arsenate reductase family protein	M1PLC0	Streptococcus_phage	1.2e-33	57.3
WP_001170346.1\|388669_389182_-	methylated-DNA--[protein]-cysteine S-methyltransferase	M1PFU9	Streptococcus_phage	1.3e-46	55.6
WP_000405832.1\|389181_389676_-	GNAT family N-acetyltransferase	M1PSC3	Streptococcus_phage	1.9e-42	52.1
WP_000858730.1\|389810_390257_+	DUF1836 domain-containing protein	NA	NA	NA	NA
WP_001097986.1\|390253_390901_+	hemolysin III family protein	NA	NA	NA	NA
WP_000689945.1\|390921_391503_-	pyridoxal 5'-phosphate synthase glutaminase subunit PdxT	NA	NA	NA	NA
WP_000138517.1\|391503_392379_-	pyridoxal 5'-phosphate synthase lyase subunit PdxS	NA	NA	NA	NA
WP_000036769.1\|392530_393910_-	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_000175413.1\|394204_395128_+	FAD:protein FMN transferase	NA	NA	NA	NA
WP_000915946.1\|395187_395793_+	NAD(P)H-dependent oxidoreductase	A0A2P0ZL77	Lactobacillus_phage	7.7e-54	54.2
WP_000673678.1\|395810_397055_+	NAD(P)H-dependent oxidoreductase	A0A2P0ZL82	Lactobacillus_phage	3.8e-55	52.7
WP_000371287.1\|398044_398302_-	DUF896 family protein	NA	NA	NA	NA
WP_000164759.1\|398343_400380_-\|tRNA	glycine--tRNA ligase subunit beta	NA	NA	NA	NA
WP_000038738.1\|400639_401557_-\|tRNA	glycine--tRNA ligase subunit alpha	NA	NA	NA	NA
WP_000369578.1\|401926_402688_-	hypothetical protein	NA	NA	NA	NA
WP_001099681.1\|402960_403803_-	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	1.7e-51	40.2
WP_001844203.1\|403916_405308_-	polysaccharide deacetylase family protein	NA	NA	NA	NA
WP_001813436.1\|405542_405920_-\|transposase	PD-(D/E)XK nuclease family transposase	NA	NA	NA	NA
WP_000915888.1\|407377_408355_+	Gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
WP_000850564.1\|408351_409434_+	DEAD/DEAH box helicase	Q5GF26	Diachasmimorpha_longicaudata_entomopoxvirus	4.4e-36	31.0
WP_001040724.1\|410930_412127_-	elongation factor Tu	A0A076FFS6	Aureococcus_anophage	7.3e-32	29.6
WP_000348122.1\|413037_413907_-	aquaporin family protein	NA	NA	NA	NA
WP_000248972.1\|414129_414810_-	LPXTG cell wall anchor domain-containing protein	NA	NA	NA	NA
WP_001844237.1\|416045_416747_-	hypothetical protein	NA	NA	NA	NA
WP_000935665.1\|416857_417112_-	hypothetical protein	NA	NA	NA	NA
WP_000151786.1\|417469_418003_-\|transposase	IS630 family transposase	NA	NA	NA	NA

DBSCAN-SWA_3

490607 : 497361

Streptococcus_phage(50.0%)

protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000081006.1\|490607_491576_+	NAD(P)/FAD-dependent oxidoreductase	Q9JRK7	Streptococcus_phage	2.8e-66	100.0
WP_000011276.1\|491609_492521_-	DNA-binding protein WhiA	Q7AWZ3	Streptococcus_phage	2.3e-155	100.0
WP_001231086.1\|492517_493495_-	YvcK family protein	A1IMD5	Streptococcus_phage	1.2e-184	100.0
WP_000163033.1\|493491_494382_-	RNase adapter RapZ	A0A0R8VB27	Thermobifida_phage	3.9e-06	29.8
WP_001140412.1\|494433_494814_-	RidA family protein	NA	NA	NA	NA
WP_000422599.1\|494824_495412_-	YihA family ribosome biogenesis GTP-binding protein	NA	NA	NA	NA
WP_000106346.1\|495420_496653_-\|protease	ATP-dependent Clp protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	4.2e-131	59.0
WP_000442275.1\|496684_496855_-	hypothetical protein	NA	NA	NA	NA
WP_000162484.1\|496854_497361_-	dihydrofolate reductase	G3MBI7	Bacillus_virus	6.7e-27	42.5

DBSCAN-SWA_4

780091 : 787423

uncultured_Mediterranean_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000167830.1\|780091_780793_+	UDP-glucose 4-epimerase GalE	A0A2K9L1R4	Tupanvirus	1.2e-34	36.5
WP_000777242.1\|781215_782175_+	ABC transporter permease	A0A2H4IY97	uncultured_Caudovirales_phage	1.2e-56	40.8
WP_001193676.1\|782164_783121_+	iron chelate uptake ABC transporter family permease subunit	NA	NA	NA	NA
WP_000764306.1\|783117_783870_+	ABC transporter ATP-binding protein	W6JKT0	Anomala_cuprea_entomopoxvirus	5.6e-14	27.9
WP_000858258.1\|783965_784931_+	siderophore ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_000821640.1\|785155_785398_-	membrane protein insertion efficiency factor YidD	A0A2H4PQM5	Staphylococcus_phage	1.3e-17	59.4
WP_001222228.1\|785397_786120_-	rRNA pseudouridine synthase	NA	NA	NA	NA
WP_000105314.1\|786106_786676_-	segregation/condensation protein B	A0A1B1IVT7	uncultured_Mediterranean_phage	6.6e-15	34.9
WP_000351907.1\|786694_787423_-	segregation/condensation protein A	A0A1B1IVW1	uncultured_Mediterranean_phage	5.3e-09	22.3

DBSCAN-SWA_5

1274707 : 1321491

Streptococcus_phage(20.0%)

bacteriocin,protease,tRNA,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000424474.1\|1274707_1275082_+\|bacteriocin	SPH_0224 family bacteriocin-like peptide	NA	NA	NA	NA
WP_000619779.1\|1275289_1276192_+	hypothetical protein	NA	NA	NA	NA
WP_000424457.1\|1276247_1276487_+	hypothetical protein	NA	NA	NA	NA
WP_000072926.1\|1276483_1277212_+	hypothetical protein	NA	NA	NA	NA
WP_000770313.1\|1278346_1278586_+	hypothetical protein	NA	NA	NA	NA
WP_000058766.1\|1278604_1278850_+	hypothetical protein	M1Q0Z8	Streptococcus_phage	1.7e-15	57.6
WP_001035356.1\|1279135_1280974_+	pneumococcal surface protein A	NA	NA	NA	NA
WP_001282984.1\|1281374_1282496_+\|tRNA	tRNA 2-thiouridine(34) synthase MnmA	NA	NA	NA	NA
WP_000193625.1\|1282636_1283092_+	NUDIX hydrolase	NA	NA	NA	NA
WP_000220964.1\|1283101_1285015_+\|tRNA	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG	NA	NA	NA	NA
WP_000331983.1\|1285438_1287118_-	ribonuclease J	NA	NA	NA	NA
WP_000639577.1\|1287119_1287353_-	DNA-dependent RNA polymerase auxiliary subunit epsilon family protein	NA	NA	NA	NA
WP_000184676.1\|1287734_1287956_+	hypothetical protein	NA	NA	NA	NA
WP_000974043.1\|1288168_1288321_-\|bacteriocin	fratricide two-peptide bacteriocin subunit CibB	NA	NA	NA	NA
WP_000180803.1\|1288322_1288508_-\|bacteriocin	fratricide two-peptide bacteriocin subunit CibA	NA	NA	NA	NA
WP_000865727.1\|1288685_1289369_+\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB	NA	NA	NA	NA
WP_000569825.1\|1289365_1289803_+	ribosomal protein S18-alanine N-acetyltransferase	NA	NA	NA	NA
WP_000655053.1\|1289792_1290803_+\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD	NA	NA	NA	NA
WP_000288032.1\|1295274_1296891_+	ABC transporter ATP-binding protein	A0A1V0SE00	Indivirus	1.7e-28	36.0
WP_001818694.1\|1296910_1297588_+	hypothetical protein	NA	NA	NA	NA
WP_000432158.1\|1297783_1298110_+	hypothetical protein	NA	NA	NA	NA
WP_000777225.1\|1298129_1298633_+	asparagine synthase	NA	NA	NA	NA
WP_000399185.1\|1298613_1299324_+	hypothetical protein	NA	NA	NA	NA
WP_001283046.1\|1299335_1300085_+	PIG-L family deacetylase	NA	NA	NA	NA
WP_001017607.1\|1300097_1301270_+	nucleotide sugar dehydrogenase	M1IJ73	Paramecium_bursaria_Chlorella_virus	1.6e-79	42.9
WP_000570712.1\|1301664_1302528_+	MutR family transcriptional regulator	NA	NA	NA	NA
WP_000933479.1\|1302813_1303047_+	hypothetical protein	NA	NA	NA	NA
WP_000738306.1\|1303068_1303746_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_000720787.1\|1303757_1304423_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_000862427.1\|1304494_1305721_+	MFS transporter	NA	NA	NA	NA
WP_001141657.1\|1306219_1306876_+	AzlC family ABC transporter permease	NA	NA	NA	NA
WP_000253914.1\|1306865_1307189_+	AzlD domain-containing protein	NA	NA	NA	NA
WP_000724961.1\|1307292_1308123_+	amino acid ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_000724935.1\|1308344_1309175_+	amino acid ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_000694501.1\|1309328_1310183_+	MetQ/NlpA family ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_000231827.1\|1310282_1311656_+	M20/M25/M40 family metallo-hydrolase	NA	NA	NA	NA
WP_000085676.1\|1311648_1312710_+	methionine ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	6.7e-29	35.7
WP_000444642.1\|1312711_1313404_+	ABC transporter permease	NA	NA	NA	NA
WP_000748394.1\|1313433_1314003_-	MptD family putative ECF transporter S component	NA	NA	NA	NA
WP_000532354.1\|1314137_1314752_+	YesL family protein	NA	NA	NA	NA
WP_171800966.1\|1314753_1316400_+	sensor histidine kinase	NA	NA	NA	NA
WP_000278866.1\|1316411_1317698_+	response regulator transcription factor	NA	NA	NA	NA
WP_000729036.1\|1317758_1318292_+	hypothetical protein	NA	NA	NA	NA
WP_000692018.1\|1318369_1318840_+	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	NA	NA	NA	NA
WP_000075791.1\|1319132_1320395_-	divalent metal cation transporter	NA	NA	NA	NA
WP_041179081.1\|1320537_1321491_-\|transposase	IS30 family transposase	H7BWC8	unidentified_phage	1.3e-34	35.4

DBSCAN-SWA_6

1472209 : 1542466

Streptococcus_phage(25.0%)

protease,holin,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001063397.1\|1472209_1474315_+\|protease	ATP-dependent Clp protease ATP-binding subunit	H6X3M6	Enterobacteria_phage	5.8e-117	37.7
WP_001818716.1\|1475037_1476057_+	hypothetical protein	NA	NA	NA	NA
WP_000386786.1\|1478074_1478983_+	hypothetical protein	NA	NA	NA	NA
WP_001220022.1\|1478984_1480883_+	YcaO-like family protein	NA	NA	NA	NA
WP_001155321.1\|1481407_1482361_-\|transposase	IS30-like element ISSpn8 family transposase	H7BWC8	unidentified_phage	1.6e-34	35.2
WP_000378912.1\|1482730_1483030_+	hypothetical protein	NA	NA	NA	NA
WP_000417117.1\|1483031_1483802_+	SagB/ThcOx family dehydrogenase	NA	NA	NA	NA
WP_001818718.1\|1483821_1483986_+	hypothetical protein	NA	NA	NA	NA
WP_000032550.1\|1487805_1488288_-	S-ribosylhomocysteine lyase	NA	NA	NA	NA
WP_000743578.1\|1488382_1489867_-	DUF1846 domain-containing protein	NA	NA	NA	NA
WP_001156799.1\|1490019_1491627_+	alpha-glucosidase	NA	NA	NA	NA
WP_001022232.1\|1491784_1491958_+	hypothetical protein	NA	NA	NA	NA
WP_000091069.1\|1494524_1495970_+	LCP family protein	A0A1X9I5X1	Streptococcus_phage	3.1e-133	59.9
WP_000565348.1\|1495971_1496703_+	tyrosine-protein phosphatase CpsB	NA	NA	NA	NA
WP_000664172.1\|1496711_1497404_+	capsular polysaccharide biosynthesis protein CpsC	A0A1X9I5E1	Streptococcus_phage	6.1e-63	56.3
WP_001142515.1\|1497413_1498079_+	polysaccharide biosynthesis tyrosine autokinase CpsD	A0A1X9I5D6	Streptococcus_phage	1.1e-72	60.7
WP_001053205.1\|1498219_1499356_+	glycosyltransferase family 4 protein	NA	NA	NA	NA
WP_001079795.1\|1499348_1499900_+	acyltransferase	NA	NA	NA	NA
WP_000862350.1\|1499896_1501051_+	glycosyltransferase family 4 protein	NA	NA	NA	NA
WP_000672721.1\|1501167_1502472_+	oligosaccharide repeat unit polymerase	NA	NA	NA	NA
WP_001818726.1\|1502657_1503827_+	oligosaccharide flippase family protein	NA	NA	NA	NA
WP_001214397.1\|1503894_1504965_+	UDP-glucuronate 4-epimerase Gla	A0A291LAD7	Escherichia_phage	7.3e-23	27.6
WP_000685088.1\|1504993_1506226_+	nucleotide sugar dehydrogenase	M1I6D5	Acanthocystis_turfacea_Chlorella_virus	6.3e-103	49.9
WP_000268343.1\|1506441_1506624_+	hypothetical protein	NA	NA	NA	NA
WP_000676139.1\|1508431_1509289_+	glucose-1-phosphate thymidylyltransferase RfbA	K7QKA7	Escherichia_phage	7.4e-95	61.1
WP_000131462.1\|1509289_1509886_+	dTDP-4-dehydrorhamnose 3,5-epimerase family protein	H9NC63	Sphingomonas_phage	5.1e-10	33.1
WP_000141505.1\|1509895_1510945_+	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	8.3e-72	45.1
WP_001869275.1\|1511937_1512372_+\|transposase	transposase	NA	NA	NA	NA
WP_000842605.1\|1513289_1515272_+	peptide ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_001032517.1\|1515572_1520876_+	YSIRK signal domain/LPXTG anchor domain surface protein	NA	NA	NA	NA
WP_001040002.1\|1521042_1523202_-	penicillin-binding protein 1A	NA	NA	NA	NA
WP_000611596.1\|1523198_1523795_-	Holliday junction resolvase RecU	A0A1L2JY30	Aeribacillus_phage	8.7e-18	33.9
WP_000179549.1\|1523860_1524388_+	DUF1273 domain-containing protein	NA	NA	NA	NA
WP_000146522.1\|1524457_1524787_+	cell division regulator GpsB	NA	NA	NA	NA
WP_000711408.1\|1525272_1526430_+	class I SAM-dependent RNA methyltransferase	NA	NA	NA	NA
WP_000039278.1\|1526442_1527837_+	mid-cell-anchored protein MapZ	NA	NA	NA	NA
WP_000158793.1\|1527912_1529337_+	NADP-dependent phosphogluconate dehydrogenase	M4QQM4	Ostreococcus_lucimarinus_virus	2.1e-41	29.6
WP_000518008.1\|1529348_1530038_+	response regulator transcription factor	NA	NA	NA	NA
WP_000771100.1\|1530135_1531092_+\|holin	choline-binding protein CbpC	NA	NA	NA	NA
WP_000765667.1\|1531209_1532442_-	MFS transporter	NA	NA	NA	NA
WP_001818729.1\|1532484_1533072_-	lanthionine synthetase	NA	NA	NA	NA
WP_000196971.1\|1533969_1534299_+\|transposase	transposase	NA	NA	NA	NA
WP_000163315.1\|1534420_1535299_+	mevalonate kinase	NA	NA	NA	NA
WP_000373452.1\|1535280_1536234_+	diphosphomevalonate decarboxylase	NA	NA	NA	NA
WP_000562440.1\|1536220_1537228_+	phosphomevalonate kinase	NA	NA	NA	NA
WP_000210618.1\|1537211_1538222_+	type 2 isopentenyl-diphosphate Delta-isomerase	NA	NA	NA	NA
WP_001224637.1\|1538299_1538998_+	cell wall-active antibiotics response protein	NA	NA	NA	NA
WP_000743686.1\|1538994_1539990_+	sensor histidine kinase	NA	NA	NA	NA
WP_000698434.1\|1540003_1540636_+	response regulator transcription factor	NA	NA	NA	NA
WP_001854757.1\|1540636_1540879_+	DNA alkylation repair protein	NA	NA	NA	NA
WP_078157354.1\|1540803_1541112_+	DNA alkylation repair protein	NA	NA	NA	NA
WP_000754502.1\|1541552_1541792_+	hypothetical protein	NA	NA	NA	NA
WP_078157356.1\|1541836_1542466_+\|protease	serine protease	NA	NA	NA	NA

DBSCAN-SWA_7

1600015 : 1713416

104

Klosneuvirus(20.0%)

bacteriocin,protease,tRNA,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001809505.1\|1600015_1600186_-\|transposase	transposase	NA	NA	NA	NA
WP_000628994.1\|1600835_1602059_-	ROK family transcriptional regulator	NA	NA	NA	NA
WP_001059636.1\|1602226_1603549_+	PTS sugar transporter subunit IIC	NA	NA	NA	NA
WP_000236903.1\|1603550_1605437_+	DUF4838 domain-containing protein	NA	NA	NA	NA
WP_000836780.1\|1605604_1605949_+	PTS lactose/cellobiose transporter subunit IIA	NA	NA	NA	NA
WP_000429427.1\|1605958_1607371_+	6-phospho-beta-galactosidase	NA	NA	NA	NA
WP_000359731.1\|1607440_1609120_+	PTS transporter subunit EIIC	NA	NA	NA	NA
WP_001809506.1\|1609245_1610685_-	TrkH family potassium uptake protein	NA	NA	NA	NA
WP_000691685.1\|1610688_1612038_-	Trk system potassium transporter TrkA	NA	NA	NA	NA
WP_001063601.1\|1612225_1613074_+	S-adenosyl-l-methionine hydroxide adenosyltransferase family protein	NA	NA	NA	NA
WP_000403169.1\|1613088_1613637_+	ECF-type riboflavin transporter substrate-binding protein	NA	NA	NA	NA
WP_000693288.1\|1613643_1613946_+	hypothetical protein	NA	NA	NA	NA
WP_000656538.1\|1614047_1615730_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	4.5e-19	34.4
WP_001148102.1\|1615714_1616545_+	energy-coupling factor transporter transmembrane protein EcfT	NA	NA	NA	NA
WP_000181374.1\|1616737_1617241_+\|tRNA	tRNA (cytidine(34)-2'-O)-methyltransferase	NA	NA	NA	NA
WP_000185833.1\|1617693_1618257_+	ECF transporter S component	NA	NA	NA	NA
WP_000678692.1\|1618270_1618897_+	phosphatase PAP2 family protein	NA	NA	NA	NA
WP_000525617.1\|1619008_1619881_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_153232345.1\|1620009_1620147_+	hypothetical protein	NA	NA	NA	NA
WP_000781144.1\|1620570_1621485_+	ThiF family adenylyltransferase	NA	NA	NA	NA
WP_000170500.1\|1621477_1622491_+	hypothetical protein	NA	NA	NA	NA
WP_001236730.1\|1622474_1624067_+	ABC transporter ATP-binding protein	A0A1V0SJ29	Klosneuvirus	9.2e-14	25.1
WP_000867291.1\|1625344_1625686_+	hypothetical protein	NA	NA	NA	NA
WP_000418402.1\|1626097_1626685_+	DNA-directed RNA polymerase subunit delta	NA	NA	NA	NA
WP_000105242.1\|1627074_1628682_+	CTP synthase	A0A1J0FA14	Only_Syngen_Nebraska_virus	8.9e-142	47.0
WP_000026639.1\|1629240_1630872_-	Na/Pi cotransporter family protein	NA	NA	NA	NA
WP_000795174.1\|1631164_1636144_+	bacterial Ig-like domain-containing protein	NA	NA	NA	NA
WP_001096743.1\|1636233_1637430_+	phosphoglycerate kinase	NA	NA	NA	NA
WP_000119900.1\|1637565_1638093_+	aromatic acid exporter family protein	NA	NA	NA	NA
WP_000659547.1\|1638169_1638526_+	transcriptional repressor GlnR	NA	NA	NA	NA
WP_001122900.1\|1638562_1639909_+	type I glutamate--ammonia ligase	NA	NA	NA	NA
WP_001808898.1\|1640004_1640124_-	hypothetical protein	NA	NA	NA	NA
WP_000410533.1\|1640088_1640238_+	hypothetical protein	NA	NA	NA	NA
WP_001220744.1\|1640689_1641967_+	restriction endonuclease subunit S	A0A1V0SKS6	Klosneuvirus	5.3e-12	29.8
WP_000229456.1\|1641914_1643198_-	restriction endonuclease subunit S	A0A1V0SLK8	Klosneuvirus	8.2e-13	25.6
WP_001088689.1\|1645724_1646234_+	DUF2812 domain-containing protein	NA	NA	NA	NA
WP_000255782.1\|1646397_1647432_+	heat-inducible transcriptional repressor HrcA	NA	NA	NA	NA
WP_000046031.1\|1647458_1647983_+	nucleotide exchange factor GrpE	NA	NA	NA	NA
WP_000034662.1\|1648462_1650286_+	molecular chaperone DnaK	A0A0N9QXN8	Chrysochromulina_ericina_virus	1.3e-133	47.2
WP_000115729.1\|1650298_1650652_+	hypothetical protein	NA	NA	NA	NA
WP_001066295.1\|1650856_1651993_+	molecular chaperone DnaJ	E3T4P7	Cafeteria_roenbergensis_virus	2.4e-24	31.3
WP_001813906.1\|1652342_1652582_-	hypothetical protein	NA	NA	NA	NA
WP_000777753.1\|1652743_1653031_-	hypothetical protein	NA	NA	NA	NA
WP_001278304.1\|1653040_1653451_-	HIT family protein	B5LJ12	Mycobacterium_phage	4.4e-05	31.6
WP_000889923.1\|1653518_1654250_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	9.0e-25	28.6
WP_000653751.1\|1654246_1655296_+	ABC transporter permease	NA	NA	NA	NA
WP_000132572.1\|1655463_1655793_-	hypothetical protein	NA	NA	NA	NA
WP_000682133.1\|1656069_1656408_+	response regulator transcription factor	NA	NA	NA	NA
WP_001219141.1\|1656412_1657150_+	response regulator transcription factor	NA	NA	NA	NA
WP_001099892.1\|1657163_1658504_+	sensor histidine kinase	NA	NA	NA	NA
WP_000358811.1\|1658547_1658703_-	quorum-sensing system pheromone BlpC	NA	NA	NA	NA
WP_001069071.1\|1658759_1660121_-\|bacteriocin	bacteriocin secretion accessory protein	NA	NA	NA	NA
WP_000205166.1\|1661713_1662301_-	peptidase C39	NA	NA	NA	NA
WP_001093259.1\|1662582_1662780_+\|bacteriocin	bacteriocin-like peptide BlpI	NA	NA	NA	NA
WP_001093248.1\|1663246_1663516_+\|bacteriocin	bacteriocin-like peptide BlpJ	NA	NA	NA	NA
WP_000379964.1\|1663584_1663815_+\|bacteriocin	bacteriocin-like peptide BlpU	NA	NA	NA	NA
WP_001844187.1\|1663817_1663937_+	hypothetical protein	NA	NA	NA	NA
WP_000727118.1\|1664235_1664400_+	hypothetical protein	NA	NA	NA	NA
WP_000846569.1\|1664396_1664792_+	hypothetical protein	NA	NA	NA	NA
WP_128887636.1\|1665876_1666680_+\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_000379879.1\|1666830_1667085_+\|bacteriocin	two-peptide bacteriocin subunit BlpM	NA	NA	NA	NA
WP_001099492.1\|1667100_1667304_+\|bacteriocin	two-peptide bacteriocin subunit BlpN	NA	NA	NA	NA
WP_001818346.1\|1667547_1667697_+\|bacteriocin	bacteriocin-like peptide BlpO	NA	NA	NA	NA
WP_000346296.1\|1667800_1667920_+	hypothetical protein	NA	NA	NA	NA
WP_000877383.1\|1668705_1669104_+	hypothetical protein	NA	NA	NA	NA
WP_000760515.1\|1669141_1669831_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_000276500.1\|1669872_1670121_+	hypothetical protein	NA	NA	NA	NA
WP_000394044.1\|1670150_1670762_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_000363002.1\|1670922_1671717_+	phosphotransferase family protein	NA	NA	NA	NA
WP_001266083.1\|1671713_1672349_+\|tRNA	tRNA (guanosine(46)-N7)-methyltransferase TrmB	NA	NA	NA	NA
WP_001808691.1\|1672474_1672954_+	ribosome maturation factor RimP	NA	NA	NA	NA
WP_000032273.1\|1672997_1674134_+	transcription termination/antitermination protein NusA	NA	NA	NA	NA
WP_000857562.1\|1674155_1674449_+	YlxR family protein	NA	NA	NA	NA
WP_001041390.1\|1674441_1674741_+	YlxQ-related RNA-binding protein	NA	NA	NA	NA
WP_000039210.1\|1674757_1677550_+	translation initiation factor IF-2	A0A2H4UTS4	Bodo_saltans_virus	3.3e-19	22.9
WP_001273601.1\|1677800_1678151_+	30S ribosome-binding factor RbfA	NA	NA	NA	NA
WP_001155321.1\|1679703_1680657_+\|transposase	IS30-like element ISSpn8 family transposase	H7BWC8	unidentified_phage	1.6e-34	35.2
WP_001068160.1\|1681932_1682115_+	hypothetical protein	NA	NA	NA	NA
WP_000668209.1\|1682111_1682252_+	hypothetical protein	NA	NA	NA	NA
WP_000368741.1\|1682519_1682753_+	DUF1858 domain-containing protein	NA	NA	NA	NA
WP_000129106.1\|1682752_1684087_+	DUF438 domain-containing protein	NA	NA	NA	NA
WP_000119708.1\|1684095_1684350_+	DUF1912 family protein	NA	NA	NA	NA
WP_000038619.1\|1684445_1684841_+	helicase	NA	NA	NA	NA
WP_033621729.1\|1685123_1685702_+	flavin reductase family protein	NA	NA	NA	NA
WP_000124556.1\|1685688_1686159_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_000550030.1\|1686158_1686737_+	AAA family ATPase	NA	NA	NA	NA
WP_000032238.1\|1686729_1689381_+\|tRNA	valine--tRNA ligase	A0A1V0S951	Catovirus	1.7e-150	41.1
WP_000033780.1\|1689450_1690206_+	DUF3883 domain-containing protein	NA	NA	NA	NA
WP_001192126.1\|1690484_1691288_+	Fic family protein	NA	NA	NA	NA
WP_001818356.1\|1692721_1692904_+	hypothetical protein	NA	NA	NA	NA
WP_000584535.1\|1693203_1694043_+	PRD domain-containing protein	NA	NA	NA	NA
WP_000120571.1\|1694060_1695899_+	PTS glucose transporter subunit IIA	NA	NA	NA	NA
WP_000151831.1\|1695911_1697327_+	glycoside hydrolase family 1 protein	A0A0B5JD41	Pandoravirus	3.3e-23	23.7
WP_001818763.1\|1697918_1698965_+\|tRNA	phenylalanine--tRNA ligase subunit alpha	A0A2I2L4E3	Orpheovirus	1.6e-27	32.8
WP_000619941.1\|1698964_1699474_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_000961596.1\|1699550_1701956_+\|tRNA	phenylalanine--tRNA ligase subunit beta	NA	NA	NA	NA
WP_000597994.1\|1702128_1703130_-	endonuclease/exonuclease/phosphatase family protein	NA	NA	NA	NA
WP_001818764.1\|1703857_1704124_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_000108203.1\|1704384_1706634_+	5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase	NA	NA	NA	NA
WP_000089976.1\|1706697_1707564_+	methylenetetrahydrofolate reductase [NAD(P)H]	NA	NA	NA	NA
WP_001118972.1\|1708248_1710462_+	polyribonucleotide nucleotidyltransferase	NA	NA	NA	NA
WP_000539972.1\|1710477_1711095_+	serine O-acetyltransferase	NA	NA	NA	NA
WP_000616911.1\|1711106_1711991_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_000591087.1\|1712072_1713416_+\|tRNA	cysteine--tRNA ligase	M1PG92	Moumouvirus	1.2e-46	35.8

DBSCAN-SWA_8

2049353 : 2058995

Streptococcus_phage(88.89%)

holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000728271.1\|2049353_2051234_+\|holin	phosphorylcholine esterase CbpE	Q332B9	Clostridium_botulinum_C_phage	1.2e-09	22.9
WP_001844069.1\|2051316_2052447_+	glutamate 5-kinase	A0A1X9I5D0	Streptococcus_phage	4.2e-114	58.4
WP_000254690.1\|2052456_2053719_+	glutamate-5-semialdehyde dehydrogenase	A0A1X9I5D4	Streptococcus_phage	1.0e-140	65.0
WP_000689717.1\|2053722_2054520_+	pyrroline-5-carboxylate reductase	A0A1X9I6T5	Streptococcus_phage	3.2e-60	50.2
WP_000033388.1\|2054739_2055378_+	dTMP kinase	M1PSC7	Streptococcus_phage	2.9e-75	67.6
WP_000806714.1\|2055374_2056265_+	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	4.9e-73	51.7
WP_000358228.1\|2056304_2056622_+	DNA replication initiation control protein YabA	M1PFV3	Streptococcus_phage	2.9e-28	60.0
WP_001166883.1\|2056624_2057494_+	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	4.5e-116	75.7
WP_001261452.1\|2057720_2058239_+	ClbS/DfsB family four-helix bundle protein	NA	NA	NA	NA
WP_000345254.1\|2058347_2058995_+	replication initiator protein A	A0A2P0VK56	Streptococcus_phage	7.0e-13	33.7

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_021003

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection