CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_015501	Porphyromonas asaccharolytica DSM 20707, complete sequence	7 crisprs	RT,DEDDh,cas3,cas5,cas8c,cas7,cas4,cas1,cas2,csa3	2	3	0	1

1. NC_015501

CRISPR-Cas detection and classification

Crispr_ID: NC_015501_1

• CRISPR_ID: NC_015501_1
• CRISPR_location: 306551-306633
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_015501_1

Consensus_repeat	Method
ACGGACGCACGAACCGTGCGTCCCTACA	CRISPRCasFinder

spacers of NC_015501_1

>1.1|306579|27|NC_015501|CRISPRCasFinder
TTTCGCTATACGTCTCGCTTGGACACA

CRISPR arrays and Neighbor proteins around NC_015501_1

CRISPR arrays

The CRISPR arrays of NC_015501_1

>merge|NC_015501|1|306551-306633|CRISPRCasFinder
ACGGACGCACGAACCGTGCGTCCCTACATTTCGCTATACGTCTCGCTTGGACACAACGGACGCACGAGCCGTGCGTCCCTACA

>NC_015501|1|1|306551-306633|CRISPRCasFinder
ACGGACGCACGAACCGTGCGTCCCTACA	TTTCGCTATACGTCTCGCTTGGACACA
ACGGACGCACGAGCCGTGCGTCCCTACA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015501.1|WP_013759887.1|320421_322734_-|carboxypeptidase-like-regulatory-domain-containing-protein	unknown	unknown	gnl|CDD|372685
NC_015501.1|WP_013759885.1|312360_313539_+|hypothetical-protein	unknown	unknown	unknown
NC_015501.1|WP_044211490.1|316056_316512_-|50S-ribosomal-protein-L13	unknown	unknown	gnl|CDD|181703
NC_015501.1|WP_052306458.1|297802_299287_-|tRNA-lysidine(34)-synthetase-TilS	unknown	unknown	gnl|CDD|238950
NC_015501.1|WP_004330535.1|315655_316042_-|30S-ribosomal-protein-S9	unknown	unknown	gnl|CDD|178888
NC_015501.1|WP_013759884.1|311641_312340_+|ribonuclease-H-family-protein	unknown	unknown	gnl|CDD|260015
NC_015501.1|WP_013759880.1|304231_305158_-|magnesium-transporter-CorA-family-protein	unknown	unknown	gnl|CDD|213361
NC_015501.1|WP_004330515.1|314526_315417_-|30S-ribosomal-protein-S2	unknown	unknown	gnl|CDD|235396
NC_015501.1|WP_174258531.1|308513_310589_+|transketolase	unknown	unknown	gnl|CDD|223100
NC_015501.1|WP_004330451.1|303370_304210_-|zinc-transporter-ZupT	unknown	unknown	gnl|CDD|235253
NC_015501.1|WP_013759878.1|300259_301372_-|Nif3-like-dinuclear-metal-center-hexameric-protein	unknown	unknown	gnl|CDD|376614
NC_015501.1|WP_013759876.1|296286_297759_-|RNA-methyltransferase	unknown	unknown	gnl|CDD|236981
NC_015501.1|WP_004330471.1|310601_311627_+|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|274350
NC_015501.1|WP_013759879.1|301390_303133_-|aspartate--tRNA-ligase	unknown	unknown	gnl|CDD|234775
NC_015501.1|WP_004330477.1|292671_294045_-|phosphoribosylamine--glycine-ligase	unknown	unknown	gnl|CDD|234856
NC_015501.1|WP_013759875.1|294041_296258_-|S9-family-peptidase	unknown	unknown	gnl|CDD|366374
NC_015501.1|WP_004330500.1|299365_300247_-|hypothetical-protein	unknown	unknown	gnl|CDD|224495
NC_015501.1|WP_044211148.1|316982_319712_-|pyruvate,-phosphate-dikinase	unknown	unknown	gnl|CDD|236446
NC_015501.1|WP_004330560.1|290070_291831_+|T9SS-type-A-sorting-domain-containing-protein	unknown	unknown	gnl|CDD|275036
NC_015501.1|WP_004330453.1|313690_314515_-|elongation-factor-Ts	unknown	unknown	gnl|CDD|236491

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015501.1|WP_013759887.1|320421_322734_-|carboxypeptidase-like-regulatory-domain-containing-protein	gnl|CDD|372685	pfam13715, CarbopepD_reg_2, CarboxypepD_reg-like domain. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 90 amino acids in length. The family is found in association with pfam07715 and pfam00593.	5.19428e-11
NC_015501.1|WP_044211490.1|316056_316512_-|50S-ribosomal-protein-L13	gnl|CDD|181703	PRK09216, rplM, 50S ribosomal protein L13; Reviewed.	2.14502e-71
NC_015501.1|WP_052306458.1|297802_299287_-|tRNA-lysidine(34)-synthetase-TilS	gnl|CDD|238950	cd01992, PP-ATPase, N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This domain has a strongly conserved motif SGGXD at the N terminus.	2.1978e-54
NC_015501.1|WP_004330535.1|315655_316042_-|30S-ribosomal-protein-S9	gnl|CDD|178888	PRK00132, rpsI, 30S ribosomal protein S9; Reviewed.	1.43309e-69
NC_015501.1|WP_013759884.1|311641_312340_+|ribonuclease-H-family-protein	gnl|CDD|260015	cd13935, RNase_H_bacteria_like, RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner. This family includes bacterial ribonuclease H (RNase H) enzymes. RNases are divided into two major families, Type 1 and Type 2, based on amino acid sequence similarities and biochemical properties. RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner in the presence of divalent cations. RNase H is widely present in various organisms, including bacteria, archaea and eukaryotes. Most prokaryotic and eukaryotic genomes contain multiple RNase H genes. Despite the lack of amino acid sequence homology, type 1 and type 2 RNase H share a main-chain fold and steric configurations of the four acidic active-site residues and have the same catalytic mechanism and functions in cells. RNase H is involved in DNA replication, repair and transcription. One of the important functions of RNase H is to remove Okazaki fragments during DNA replication. RNase H inhibitors have been explored as an anti-HIV drug target because RNase H inactivation inhibits reverse transcription.	7.63026e-50
NC_015501.1|WP_013759880.1|304231_305158_-|magnesium-transporter-CorA-family-protein	gnl|CDD|213361	cd12827, EcCorA_ZntB-like_u2, uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family. A uncharacterized subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB (EcCorA-ZntB_like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes.The EcCorA-ZntB-like family includes the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs, which can also transport Co2+, and Ni2+. Structures of the intracellular domain of EcCorA-ZntB-like family members, Vibrio parahaemolyticus and Salmonella typhimurium ZntB, form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.	4.3748e-112
NC_015501.1|WP_004330515.1|314526_315417_-|30S-ribosomal-protein-S2	gnl|CDD|235396	PRK05299, rpsB, 30S ribosomal protein S2; Provisional.	6.68661e-143
NC_015501.1|WP_174258531.1|308513_310589_+|transketolase	gnl|CDD|223100	COG0021, TktA, Transketolase [Carbohydrate transport and metabolism].	0
NC_015501.1|WP_004330451.1|303370_304210_-|zinc-transporter-ZupT	gnl|CDD|235253	PRK04201, PRK04201, zinc transporter ZupT; Provisional.	4.1872e-128
NC_015501.1|WP_013759878.1|300259_301372_-|Nif3-like-dinuclear-metal-center-hexameric-protein	gnl|CDD|376614	pfam01784, NIF3, NIF3 (NGG1p interacting factor 3). This family contains several NIF3 (NGG1p interacting factor 3) protein homologs. NIF3 interacts with the yeast transcriptional coactivator NGG1p which is part of the ADA complex, the exact function of this interaction is unknown.	4.51947e-41
NC_015501.1|WP_013759876.1|296286_297759_-|RNA-methyltransferase	gnl|CDD|236981	PRK11783, rlmL, bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2))-methyltransferase RlmL.	5.63603e-121
NC_015501.1|WP_004330471.1|310601_311627_+|tetratricopeptide-repeat-protein	gnl|CDD|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	5.64136e-10
NC_015501.1|WP_013759879.1|301390_303133_-|aspartate--tRNA-ligase	gnl|CDD|234775	PRK00476, aspS, aspartyl-tRNA synthetase; Validated.	0
NC_015501.1|WP_004330477.1|292671_294045_-|phosphoribosylamine--glycine-ligase	gnl|CDD|234856	PRK00885, PRK00885, phosphoribosylamine--glycine ligase; Provisional.	0
NC_015501.1|WP_013759875.1|294041_296258_-|S9-family-peptidase	gnl|CDD|366374	pfam00930, DPPIV_N, Dipeptidyl peptidase IV (DPP IV) N-terminal region. This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.	4.38797e-70
NC_015501.1|WP_004330500.1|299365_300247_-|hypothetical-protein	gnl|CDD|224495	COG1579, COG1579, Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only].	2.09028e-24
NC_015501.1|WP_044211148.1|316982_319712_-|pyruvate,-phosphate-dikinase	gnl|CDD|236446	PRK09279, PRK09279, pyruvate phosphate dikinase; Provisional.	0
NC_015501.1|WP_004330560.1|290070_291831_+|T9SS-type-A-sorting-domain-containing-protein	gnl|CDD|275036	TIGR04183, hypothetical_protein, Por secretion system C-terminal sorting domain. Species that include Porphyromonas gingivalis, Fibrobacter succinogenes, Flavobacterium johnsoniae, Cytophaga hutchinsonii, Gramella forsetii, Prevotella intermedia, and Salinibacter ruber average twenty or more copies of a C-terminal domain, represented by this model, associated with sorting to the outer membrane and covalent modification.	6.56841e-08
NC_015501.1|WP_004330453.1|313690_314515_-|elongation-factor-Ts	gnl|CDD|236491	PRK09377, tsf, elongation factor Ts; Provisional.	8.55352e-108

Protein sequences

>NC_015501.1|WP_013759880.1|304231_305158_-|magnesium-transporter-CorA-family-protein
MRKFYLPKQQFTQVDTLEPHTWVKVVQPTSEDIDYLCDELGIPDGFIGDTADSDERPRTEEEDGWRLTIIRIPIETPEGTTPYNTVPVGIISHLEKQLIVTICYHRTDLMPDFIQHNQRKGISVDTDIDFILRLIMSSAVWFLKYLKQISFLILETEEALEKSIRNEDLLQMMRLQKCFVYFNTSIRGNESVIGRFKVSHYEQYDTDLAEDVTIELNQAYNMVNVYSDVMNGTMDAFGGIINNNINTIMRRMTSISMILMLPTLVASLYGMNVDLPWAEHPLAFIGIMVVCLIFSAIAFWLFKRIHWF
>NC_015501.1|WP_004330451.1|303370_304210_-|zinc-transporter-ZupT
MLLDTSNTQVFYAFLITLWAGLSTGIGSALIFFTKRTNRIFLSVSLGFSAGVMVYVSFVELFRSAETTMTPFYGERLATLYATLAFFAGVALIGIIDRLIPEAENPHELPDQSAVRNLQNESVQTTTVHQQSLLRTGMVTAIVLAIHNFPEGMVTFMSALTDLSLALPIAIAIALHNIPEGISVAIPIYHATGNKRKAFFLSLASGLAEPIGGLLGFLLLRPFLTPTVLGCCFAIIAGIMVYISFDELLPAAERFGHHHTALYGLIGGMAFMALSLLLL
>NC_015501.1|WP_013759879.1|301390_303133_-|aspartate--tRNA-ligase
MYRTHTCGALRASDEGQQVTLAGWVAKIRRMGAMTFLDLRDRYGITQIFFDESHQGLLSEVGREWVLAVTGTVRLRSSVNEKIPTGQIEILADRMEVLNRADTPPFTIEDVSDGGDDLRMKYRYLDLRRRPVLSNIELRHRMTMETRRYLDGLHFLEIETPMLIGSTPEGARDFVVPSRMNPGQFYALPQSPQTFKQLLMVAGMDRYFQIVKCFRDEDLRADRQPEFTQIDCEMSFVEQDDILSTFEGLAKHLFKEIRGIDLPTPLRRMTWYEAMDRYGSDKPDLRFGMEIEEVTETIQGHGFGVVDSAAYIGAIVVTGKADYTRKQIDQLTDFVKRPQVGAKGLLWLRYQPDGTMKSSFDKFLTADQLKALADKLSMQPGDIAFLISGDKRPAQKQLGTLRLHIASELGLMKPGQYECLWVVDFPLLEWDEETQRYYAMHHPFTAPKPEDQDRLESDPGSVRADAYDMVINGVEVGGGSIRIHDAELQARVFATLGFTKERAEEQFGFLMNAFKYGAPPHGGIAFGLDRWVSLMAELDSIRDCIAFPKNNSGRDVMIDAPARLDPEQLDELHLTVRETL
>NC_015501.1|WP_013759878.1|300259_301372_-|Nif3-like-dinuclear-metal-center-hexameric-protein
MVTIGDVVRTVETCYPLSYQESYDNSGLQVGDVTQPLRGIMLAVETTEAVLEECLQRGCNLLISHHPILFRGLKRVTSATYQERCVAFALRNNIAIYACHTSADNETTQGVNHYLANLIGLKREGRRPMMPQRGRFYKLQTFIPHSHADALRSAYEEAGIGSLGGYTGCSYSCSGVGRFRPGSETHPTIGTHGAMEAVEEEMISVLVPQERLSQAVTTLVATHPYEVPAYEVIPIVMDHPTSGLGVIGELPSALTPQELLELLATLPAVERIAYSNPPTQPIRRIALCGGSGGGHEFIGEAMRSGAEVYITGEAKYNDYLDVQGRLWLITLGHFESEHCTRTMLYDALSDKYRNFVIHMSDADTNPIHYF
>NC_015501.1|WP_004330500.1|299365_300247_-|hypothetical-protein
MSTNTTTHEVAERSIREKLIALKRLQETLTSIDKIKLLRGELPQAIEDLADEIEGLKTRLEKYNAAAKKLSQSVSGENQKISTANDKLETLKEQLNAVSNNREYEHLSREIEFQELEIQLAQKHIREFNAELQGRKDDIAKLQERIKEREEDHQAKSEELEQIIAETRIEEEELRDRANELEAQIDERILKAFQRLRKGATNGLAVVPVEREACGGCFNHIPPQRQLEVKLHNKVIVCEYCGRVLIDPDIEEEPVELTNEQSDTKKDAKKTTTKKAASKSTKKATTSKDQADK
>NC_015501.1|WP_052306458.1|297802_299287_-|tRNA-lysidine(34)-synthetase-TilS
MSQRRTLLNHALVHQMRRTIEQYDLLDRQSQRVVIIALSGGADSTALLWGLLLLGYRCVAAHCNFHLRGEESDRDEIFVTELCDQLGVPLERASFDTYGYVAAHKGVSVEMAARKLRYDFFDKLYERYDAQSIALGHHLEDNVEQLLINLSQGAGVRGLRGMLPIREEGKYIRPLIDTPPRLIYDFLQIAEQPFVTDSTNADTSIRRNFVRHTLRPLFDELNPSFDQAVASTIHILRDLEQLQDHYIRSTLPADASQPLEVAWLRQQIAPLALLYSYFAAIDCDRLVLQQLLMDCTKSERDNSYARYEGRGGIIERYRGYLIGTTSDTLARLEQAANVCLELPTIESWQAGAVLDHPLGSIEIAVHDSSETPPPAIRTLTPYSYLVDYDQLRAAMPQLQFTASTDGEQWVVPLGMKGRKPLAKLLRDAKVLPSRRAATAQLIDNHTGATLWLVGVCRSADYQITPQTRRWAQITFTPTLSDPLARHMEPHTVAR
>NC_015501.1|WP_013759876.1|296286_297759_-|RNA-methyltransferase
MTKTFPIIAKTLPGLEPVLEQELTALGADNIQIGRRMVSYEGDLKMLYKSNLYLRTALKVLRPIYEFDAEDIDILYTTLLNFDWSQWLTADMTFAVDAVVYSSTFKHSRYVVYKTKDAIVDYFREQTGGTKRPSVKLSNPQLIFHLHIAEQHVTLCLDSSGESLHKRGYRMEQDRAPINEVLAAGILLKAGWHGQCDLMDPFCGSGTFLVEAALIATGTPPGIYRESYPFERWPDFDSELCCEVYNDDSSERSFDYHIYGSDLSPQAIAKAKRNVTRSGMSRYIDLSVGDFADQHLPHPEAETDPKCLLVMNPPYGERLSDYDLEQLYSMIGRTLKFQFAGAQAWIIAHQVEHFHAIGLKHDLREELYNGSLPCELRGYTLFEGKHKEYKEQIAQREETPQRREHGEAFHRGKEQEPRRPRAAYDKPAYSKGRGNGKPYEKPYGKSAHRGAQRTKGPHPAGSSSSGYKANIQTFGSDETFVHEAEANDNE
>NC_015501.1|WP_013759875.1|294041_296258_-|S9-family-peptidase
MTSTLRHYALWLFGALMLTLTSVLQGQTKQPLDLETVTYGGKTFRSAFYPQPVYGLAWLQSGYTYTVDGGDYRSLRVYTPTREQEQTVLTQDELVQLLKPYDNTDELYPLISYDFTPQCHYLEVELSKGLYLIDVEQKQIVGYFATGKIEKRASLLSPNERNLAVKSEEGTLLIYTIQPAGSAPQAPMLVATDEAEAAVVYGESVHQNEFGIDGGLFWSPDSRQLAFYRMDQSMVAPYPIVDMTPHKAVVQPVRYPMAGTPSHHVTLGVFHVESQQITYLATGGDPEHYLTNVAWHPNSKKVYIAELNRGQDHLFLNGYDAQTGAHVETLFEETDAHYVEPQRPMMFVPGSRGEQFVWESRREGYRQLYLYSSTGKLIRKLTDMEGEVTDIYGFDPKGERIYYQAAYPSPLERHIFASDLKRGRTIQLSKVAGTHDAIFSPDKQYYIDQLQSATIARSVMLHDNNGLQLRQIHQAPDPWVKLDMPNITVGTLLAADGKTELYYRLITPSNFDEMKEYPAIVYVYGGPHAQLVTNTPQWGASGWDLYMAQQGYIIFTVDNRGSAQRGAAFEQVIHRQVGTAEMADQMKGVEYLQSLPYVDRNRIGVYGWSFGGFMTTNLMLTHPETFKVGVAGGPVMDWSRYEIMYGERYNDAPQDNAEGYQQNNLIERAKDLKGRLLLIHGTSDNVVVWQHAQAFVKACVDAQTYPDLYYYPGHKHNVIGPDRVHLNYVITRYFLEHL
>NC_015501.1|WP_004330477.1|292671_294045_-|phosphoribosylamine--glycine-ligase
MSLIYPNTKQDKKKSTDAEFMKYAKIEMVKAPQTVLLLGSGGRECAMAAAIAESKLLKKLYIAPGNAGTAAYGTNVPDLNPAKHEAVSQFIATHGVTLLVCGPEAPLVDGLVDYLQEDARHPDLLIVGPDKAGAHLEGSKEYSKEFMRRHSIPTASYETFGPQDIEEAEEFLDQLSAPFVLKADGLAAGKGVLICQDREEAEQGLGQLFSGLYGSRGQRIVIEEFLEGIECSVFVATDGTDYCVLPVAKDYKRVGDGDTGPNTGGMGAVSPVPFADETFMQRVEERIIRPTLEGLQEEGIQYVGFLFIGLMNVAGDPYVIEYNCRLGDPETEVVLPRIESDFLELLIAMATGQVARYDLKVSPEVAMTLVLVSKGYPGHYDKGFPIQLPDPAEGIRIYHSGTATSEDGHLVTNGGRVLAITARGTTIQEAQEVCYRTATQILYEGKNYRHDIGNDLL
>NC_015501.1|WP_004330560.1|290070_291831_+|T9SS-type-A-sorting-domain-containing-protein
MNKLITRLALSITLAGGMLLPATQATAQKQLVASDLQLVEAPALREASQLRAGRAGDLVNLKTSKYVAKDINGKEHDIDAILKSGKAIMIDFSAVWCGPCWMLHTSGVLERLYSKFGPEGTNQIELFWVGADSRSTISAIKGKGGGTQGDWTKDSKGNLVPYPLFSDPKMASTLGIDVTGFPTLVLVGPGNKWIACRGEVETSDSDFKQFTGLLALFMKEEDKPQGVTFAGVTDLYVGETHKLKVSYSTVAPVTKIEWKAPEGITLKKVSDEEYQVTANKLGTYEIEATVTNKNGSATGKVTVTVSDPISSYPFFSAMDVKDKLDKGWRSIDHDGDGFGFDSFMGKGLLDRLGLKFNDPNYKPGAESSADYLISWGTFFPTETQPGKNGGVSFSGSTIEPDNELLSAPLVIPADAAKPTFSCYISSFFQANKSDELKVMVSELNGTPVELLAPQAPIGGDWKLISADLSAYKGKTILLSLIPVVNGESGIGVDQIRVTMDGTTDVEAPTLNVQTTLYPNPASDYVTVKTRVGSSIEIFATDGALLSTTQAKGEETTVALAQLPAGRYLVRITSLEGEIVLRPLIIK
>NC_015501.1|WP_174258531.1|308513_310589_+|transketolase
MTDQTLSTQEQPMSIAERAADNIRALAISMVERAKSGHPGGAMGGADFIQVLFSEQLRYDPRHPEHPARDRFFMDPGHMSPMLYAQLALAGFFTMDELAAFRSWGSPTPGHPELSRSRMIENTSGPLGQGHTYAVGAAIAAKFLQHRLGDTLMPQRIYAFISDGGIQEEISQGAGRIAGDLGLDNLIMYYDCNDIQLSTRVEDITAEDVAAKYDAWGWNVFEVPGNDPAALSQVLQDAIETSEETGAPTLIIGYTNMAYKAVDEEGNPLANLIATHGQPLSKAGASYAKTMEALGADPDNPFTIYEDVAAFYADRREELIAYWDGQYKIQEKYKKEHPDQAKLYDRWFAAEPTYDVAWLEIAQKANQATRAASATVLGELAKRVDNLIVASADLSNSDKTDGYLKGTKALEAGDFSGKFLQAGVSELTMAAICVGITLHGGMRAACGTFFVFSDYMKPVIRMAGLMEQPVIFIWSHDSFRVGEDGPTHEPVEQEAQIRLLEHLHNHSGRRALQALRPADVHEATVAWQMAMENLHTPTALILSRQNIQDLPNPTYERACQLKRGAYVVSDTTPAGETPDLTLIASGSEVSTLVQAAELLKGKGHKLRIVSVPSEGLFFDQPEAYRESVIPAGGARFGLTAGLPVTLLRLVGDMEHIHGLESFGFSAPYTVLDEKLGFTAEAVAQRIEELCR
>NC_015501.1|WP_004330471.1|310601_311627_+|tetratricopeptide-repeat-protein
MGLFSRFKKSNKKSPVSTEEVEQETTDTTQEVGQVAEQATESKADTLKANTLKFDALRALKIGEVDFAIRALRTSLEEIDDPECRLYLAQALQRKPDLAGSMAELTTILEAYPDYPVALYEATKVSNGLDQHSETIAYAERALATELETAQQAELHRMKAQAQLALSESEQALATIDQALQLTDEVPLYWLIKVKVLIALERWEEALAVALETAEKFPEEERAYLYEGLITYHEGDKERAERAFRQVVETDPFNVEGYMHLTHLVEELRGKEAAADEMEQALDMIPQPTRALLEYAASLYKACDRTEQYEGVQQLLADLPEGAETQTGEVNFANLYAGGFY
>NC_015501.1|WP_013759884.1|311641_312340_+|ribonuclease-H-family-protein
MSAKQRKWYVVWEGYRPGVYDDWQDCKMQIEGFQGAKYKSYLTAEQAQEAFELGYDEGRKLGQQHRVAKPQSNKLQVQNSVAQAPDQLIGDKVAPKGFLNHSIAVDGACSSNPGVTEYRGVYTFSHAELFRAVIPWGTNNIGEYLAIVHALALMEQGKLPPLPIYSDSKVALGWVAQARCRTRLDSTDPRSAKTYELIRRATHWLKTHTFRVPLLKWDTVAWGEIPADFGRK
>NC_015501.1|WP_013759885.1|312360_313539_+|hypothetical-protein
MRTPLLVCNIGHEAALEAGDPLHYTPPRLIRQMRSALWSLPLWASPAWLDGASWWVHPFSESLSPYLTEHELSHIAKGDVGDSELILWGYERSLARSLAKRYGLSGGETCSELPQELKPCWTRAASALFFEKYSSVPWRSRVAMITQIEELAKLLTQGACLVKLPYSSSGRGLWRINRLDSQLEETLCKLLRRHRTLLVEPLLDKLQDYGAEYYIDEAGEVQFVGLCAFETDDQGRYLDSLCQAPEKTLQQITESLSDPNELTQALAQHRAYLSREVAPYYQGAVGIDLLTYRPYGVSSRIALHPWVEINLRYTMGHYALDLYRERIPQGSPDQYRFGILSAQRAKALLSTADAPTLDDAGRLRSGLLPLTGSDLTGISHFAYLRDGEGKRK
>NC_015501.1|WP_004330453.1|313690_314515_-|elongation-factor-Ts
MSVTIEDIKKLRKMTGAGLSDCKNALNETAGDFEKAIEIIRAKGKAVAAKRSDREAAEGCVLAAHSEGFAAIVSLQCETDFVAKNEGHIALTQQILDVAMKEQPATKEDLLKLPLADGRAVAEHITDRVGSTGEKMELGSYEYLKAPYTTSYIHFGNKLAAIVAFNEAISDEMAREVAMQVASMNPVAVCEKDVPAHVLEEERKVAMDRARESGKPEAICERIVEGSIQKFYKESTLLHQPFVRDSKMDVQGYLHTASKTLTATGFKRVNLNED
>NC_015501.1|WP_004330515.1|314526_315417_-|30S-ribosomal-protein-S2
MSQVSFDQLLEAGAHFGHMPRKWNPAMAPYIFMERNGIHIIDLHKTVAKIDECAEIIKNMASSGKKILFVGTKRQAKDAVAELAKSVGMPYVTERWPGGMLTNFPTIRKAVKKMAQIDKMREDGTYNNLSKRERLQLDRQQAKLDKNLGSIRDMNRLPNALFVVDVMREHIAVREAQRLGIPVFAIVDTNANPKDIDYVIPANDDSTQAIELIISAMCQAINEGQVEYKAIKAEKEAEEAAELAPSGRRQRTGARRERIRPANAEAEREEDAEEATPETVEAEETAPANEEAANQQ
>NC_015501.1|WP_004330535.1|315655_316042_-|30S-ribosomal-protein-S9
MEQINAIGRRKAAVARVYLTEGSGKITINKKDIANYFPSSILQYIVKQPLLKLEVADKYDVMINLAGGGFKGQSEAARLGIARALIKINPEDKATLRAAGFVTRDPRVVERKKPGRPKARKKFQFSKR
>NC_015501.1|WP_044211490.1|316056_316512_-|50S-ribosomal-protein-L13
MNTLSYKTQSATKESAQKEWLVVDAEGQRLGRLCSVVAKILRGKYKPCFTPHADCGDNVIIINADKIELTGNKWDTPSYLTFSGYPGGQRTFSPRDFQKKSSRKLFEKVLKGMLPKNKLGAELLTHVRVFDGPDHTMEGVQPRKIDINTLK
>NC_015501.1|WP_044211148.1|316982_319712_-|pyruvate,-phosphate-dikinase
MKNKKRIYTFGNGSAEGNAQMRDLLGGKGANLAEMNRIGVPVPPGFTISTEVCTEYYERGREAVVADLKDDLMAAVKHIENIMGFKFGDVENPLLVSVRSGSRASMPGMMDTILNLGLNDTVVDGLARKSGNERFAWDSYRRFVQMYGDVVLGMKPVNKDDIDPFEAIIEEVKKEAGVKLDNELTTDHLKDLVKRFKKAVMKATGHDFPTDPYEQLWGAIMAVFGSWMNDRAILYRKMEGIPDDWGTAVNVQAMVFGNMGDTSATGVAFTRDAATGENLFNGEYLVNAQGEDVVAGIRTPQEITIEGSRRWAERAGIDEATRKAQYPSMEETFPEIYAELNAIQHKLEQHYHDMQDLEFTVQEGKLWLLQTRNGKRTGQAMVKIAMDQLRDNLISEEEALLRVEPAKLDELLHPVFDKKALKSAKVLSKGLPASPGAATGQIVFFADDAANWHEQGKNVIMVRIETSPEDLAGMSVAQGILTARGGMTSHAAVVARGMGKCCITGAGGIIVDYKARTVTIDDKVLHEGDFISINGSTGEIYEGQVETKAAEMDADFRQLMELANKHSKLSVRTNADTPHDAATARTFGAVGIGLCRTEHMFFEDNKIKAMREMILATDTEGRRKALAKLLPIQTEDFKGIFRAMEGLPVTVRLLDPPLHEFVPQTESGQIELAKAMGVEPKVVHDRVEQLHELNPMLGHRGCRLGNTYPEITEMQTRAILGACLELKKEGVETHPEIMVPLVGVVEEFKQQASVIRETAETLFKEQGDRIDYHVGTMIEVPRAALTADEIAKEADFFSFGTNDLTQMTFGYSRDDVNTFLPIYLDKKILKVDPFQQLDQRGVGQLVQMGAEKGRSVKPTIKLGICGEHGGDPSSVAFCHRVGLNYVSCSPFRVPIARLAAARAAVEDKK
>NC_015501.1|WP_013759887.1|320421_322734_-|carboxypeptidase-like-regulatory-domain-containing-protein
MSSKNYLRLWGVIALLLITSGALRAQAITIQGQVLASSDSTALVGASVGLFDDKGQLTTGVSTESEGQFVLQADLQVARELRISSVGYTSITIQIAGDAQGVIALGTLYMSEDSQLLDQVVVQGARSRVDKMLLFPKQAELARSQDFLSLLQTMHLRGLTIDLMNKQATIRGGAVQWQIDGVPRTIEDVQSIDPERILRIEYSDMVSARYTDRGIGGIVNVILKERLHGGSVWAQVESALTTGFVNGALGARYDRGHHSFTLDYNNGFRNYRKRFAYLETKYIAPHEELTRTEMPEASPFGYMVQNLNLSYLYKPSERQQFSATLRNEFVNYHNTSRSEIAQSGSDPFHRESSVKERSYTPALDLYYANMLSNGGKLEVNLVGSYSGGHRNFLLQDQMPTQLREVQNSVDVSRTALIGEVVYNHPFSSYFTLATGLQHTTAYSLNKYVEVTDNLLENNSYLFANAQGQLGKVQYSIGTGAKLFVVQDATDRKSFVRNQSTLSLFYSPVNHLTLVLKSTYLPTLPSLSMLSRVRQRVDDLMVTSGNPDLKAAQSLYNRFGIYYQTQLFTSNLDFSIDNTWSPILWDATYDATNGYFLMRATNGRYNRQYSISWQGGLNNLWTFLTLQGTVRYDMFRTHTGVAAYKLNSLYWDASVMMSYKGCTLGYSYVHPQWTLSGHTKSLGENSSRLMLLYKYRDWSFYASCIFPFTPRGSEYRSESLSPVIPSTSHVYILDNRNMVTVGVSWRLNFGKQLQLIDRTLQNRDSNESVVK

Crispr_ID: NC_015501_2

• CRISPR_ID: NC_015501_2
• CRISPR_location: 438606-438719
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_015501_2

Consensus_repeat	Method
TGTAGGGACGCACGGCTCATGCGTCCGTTGTGTCAA	CRISPRCasFinder

spacers of NC_015501_2

>2.1|438642|42|NC_015501|CRISPRCasFinder
AGGAGACAACCTCCGTTGTGTCACAGCGACACGTGTAACCGG

CRISPR arrays and Neighbor proteins around NC_015501_2

CRISPR arrays

The CRISPR arrays of NC_015501_2

>merge|NC_015501|2|438606-438719|CRISPRCasFinder
TGTAGGGACGCACGGCTCATGCGTCCGTTGTGTCAAAGGAGACAACCTCCGTTGTGTCACAGCGACACGTGTAACCGGTGTAGGGACGCACGGCTCGTGCGTCCGTTGTGTCAA

>NC_015501|2|2|438606-438719|CRISPRCasFinder
TGTAGGGACGCACGGCTCATGCGTCCGTTGTGTCAA	AGGAGACAACCTCCGTTGTGTCACAGCGACACGTGTAACCGG
TGTAGGGACGCACGGCTCGTGCGTCCGTTGTGTCAA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015501.1|WP_004331543.1|431540_431954_-|50S-ribosomal-protein-L22	unknown	unknown	gnl|CDD|234793
NC_015501.1|WP_155811456.1|453064_454207_+|T9SS-type-A-sorting-domain-containing-protein	unknown	unknown	gnl|CDD|275036
NC_015501.1|WP_013759960.1|455228_455933_+|PorT-family-protein	unknown	unknown	gnl|CDD|372635
NC_015501.1|WP_013759949.1|432290_433124_-|50S-ribosomal-protein-L2	unknown	unknown	gnl|CDD|236488
NC_015501.1|WP_044211177.1|445140_446199_+|leucine-rich-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|275378
NC_015501.1|WP_004331549.1|434071_434689_-|50S-ribosomal-protein-L3	unknown	unknown	gnl|CDD|234564
NC_015501.1|WP_013759954.1|443523_445137_+|leucine-rich-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|380191
NC_015501.1|WP_013759951.1|435034_437158_-|elongation-factor-G	unknown	unknown	gnl|CDD|237185
NC_015501.1|WP_004331526.1|440026_440653_-|HAD-family-phosphatase	unknown	unknown	gnl|CDD|319790
NC_015501.1|WP_004331548.1|437179_437656_-|30S-ribosomal-protein-S7	unknown	unknown	gnl|CDD|235398
NC_015501.1|WP_044211179.1|446424_450501_+|T9SS-type-A-sorting-domain-containing-protein	unknown	unknown	gnl|CDD|275036
NC_015501.1|WP_013759959.1|454446_455130_+|PorT-family-protein	unknown	unknown	gnl|CDD|372635
NC_015501.1|WP_004331537.1|438027_438405_-|30S-ribosomal-protein-S12	unknown	unknown	gnl|CDD|235355
NC_015501.1|WP_013759953.1|440659_442657_-|S9-family-peptidase	unknown	unknown	gnl|CDD|224423
NC_015501.1|WP_004331538.1|433127_433421_-|50S-ribosomal-protein-L23	unknown	unknown	gnl|CDD|235586
NC_015501.1|WP_013759950.1|433448_434072_-|50S-ribosomal-protein-L4	unknown	unknown	gnl|CDD|235404
NC_015501.1|WP_004331535.1|458585_459428_+|fumarate-hydratase	unknown	unknown	gnl|CDD|180486
NC_015501.1|WP_004331517.1|434710_435016_-|30S-ribosomal-protein-S10	unknown	unknown	gnl|CDD|179076
NC_015501.1|WP_013759957.1|450792_452940_+|hypothetical-protein	unknown	unknown	gnl|CDD|275380
NC_015501.1|WP_004331550.1|431995_432259_-|30S-ribosomal-protein-S19	unknown	unknown	gnl|CDD|178985

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015501.1|WP_004331543.1|431540_431954_-|50S-ribosomal-protein-L22	gnl|CDD|234793	PRK00565, rplV, 50S ribosomal protein L22; Reviewed.	2.9476e-49
NC_015501.1|WP_155811456.1|453064_454207_+|T9SS-type-A-sorting-domain-containing-protein	gnl|CDD|275036	TIGR04183, hypothetical_protein, Por secretion system C-terminal sorting domain. Species that include Porphyromonas gingivalis, Fibrobacter succinogenes, Flavobacterium johnsoniae, Cytophaga hutchinsonii, Gramella forsetii, Prevotella intermedia, and Salinibacter ruber average twenty or more copies of a C-terminal domain, represented by this model, associated with sorting to the outer membrane and covalent modification.	1.02942e-05
NC_015501.1|WP_013759960.1|455228_455933_+|PorT-family-protein	gnl|CDD|372635	pfam13568, OMP_b-brl_2, Outer membrane protein beta-barrel domain. This domain is found in a wide range of outer membrane proteins. This domain assumes a membrane bound beta-barrel fold.	3.11048e-12
NC_015501.1|WP_013759949.1|432290_433124_-|50S-ribosomal-protein-L2	gnl|CDD|236488	PRK09374, rplB, 50S ribosomal protein L2; Validated.	6.74902e-177
NC_015501.1|WP_044211177.1|445140_446199_+|leucine-rich-repeat-domain-containing-protein	gnl|CDD|275378	sd00031, LRR_1, leucine-rich repeats. A leucine-rich repeat (LRR) is a structural protein motif of 20-30 amino acids that is unusually rich in the hydrophobic amino acid leucine. The conserved eleven-residue sequence motif (LxxLxLxxN/CxL) within the LRRs corresponds to the beta-strand and adjacent loop regions, whereas the remaining parts of the repeats are variable. LRRs fold together to form a solenoid protein domain, termed leucine-rich repeat domain. Leucine-rich repeats are usually involved in protein-protein interactions.	4.32066e-09
NC_015501.1|WP_004331549.1|434071_434689_-|50S-ribosomal-protein-L3	gnl|CDD|234564	PRK00001, rplC, 50S ribosomal protein L3; Validated.	1.50054e-112
NC_015501.1|WP_013759954.1|443523_445137_+|leucine-rich-repeat-domain-containing-protein	gnl|CDD|380191	NF033187, internalin_J, class 1 internalin InlJ. Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface-anchored proteins with an N-terminal signal peptide, leucine-rich repeats, and a C-terminal LPXTG processing and cell surface anchoring site. See PMID:17764999 for a general discussion of internalins. Members of this family are internalin J (InlJ).	1.11643e-17
NC_015501.1|WP_013759951.1|435034_437158_-|elongation-factor-G	gnl|CDD|237185	PRK12739, PRK12739, elongation factor G; Reviewed.	0
NC_015501.1|WP_004331526.1|440026_440653_-|HAD-family-phosphatase	gnl|CDD|319790	cd02603, HAD_sEH-N_like, N-terminal lipase phosphatase domain of human soluble epoxide hydrolase, Escherichia coli YihX/HAD4 alpha-D-glucose 1-phosphate phosphatase, and related domains, may be inactive. This family includes the N-terminal phosphatase domain of human soluble epoxide hydrolase (sEH). sEH is a bifunctional enzyme with two distinct enzyme activities, the C-terminal domain has epoxide hydrolysis activity and the N-terminal domain (Ntermphos), which belongs to this family, has lipid phosphatase activity. The latter prefers mono-phosphate esters, and lysophosphatidic acids (LPAs) are the best natural substrates found to date. In addition this family includes Gallus gallus sEH and Xenopus sEH which appears to lack phosphatase activity, and Escherichia coli YihX/HAD4 which selectively hydrolyzes alpha-Glucose-1-P, phosphatase, has significant phosphatase activity against pyridoxal phosphate, and has low beta phosphoglucomutase activity. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.95142e-47
NC_015501.1|WP_004331548.1|437179_437656_-|30S-ribosomal-protein-S7	gnl|CDD|235398	PRK05302, PRK05302, 30S ribosomal protein S7; Validated.	2.93461e-96
NC_015501.1|WP_044211179.1|446424_450501_+|T9SS-type-A-sorting-domain-containing-protein	gnl|CDD|275036	TIGR04183, hypothetical_protein, Por secretion system C-terminal sorting domain. Species that include Porphyromonas gingivalis, Fibrobacter succinogenes, Flavobacterium johnsoniae, Cytophaga hutchinsonii, Gramella forsetii, Prevotella intermedia, and Salinibacter ruber average twenty or more copies of a C-terminal domain, represented by this model, associated with sorting to the outer membrane and covalent modification.	9.84352e-05
NC_015501.1|WP_013759959.1|454446_455130_+|PorT-family-protein	gnl|CDD|372635	pfam13568, OMP_b-brl_2, Outer membrane protein beta-barrel domain. This domain is found in a wide range of outer membrane proteins. This domain assumes a membrane bound beta-barrel fold.	4.09824e-10
NC_015501.1|WP_004331537.1|438027_438405_-|30S-ribosomal-protein-S12	gnl|CDD|235355	PRK05163, rpsL, 30S ribosomal protein S12; Validated.	3.97634e-88
NC_015501.1|WP_013759953.1|440659_442657_-|S9-family-peptidase	gnl|CDD|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	2.66317e-86
NC_015501.1|WP_004331538.1|433127_433421_-|50S-ribosomal-protein-L23	gnl|CDD|235586	PRK05738, rplW, 50S ribosomal protein L23; Reviewed.	1.48845e-33
NC_015501.1|WP_013759950.1|433448_434072_-|50S-ribosomal-protein-L4	gnl|CDD|235404	PRK05319, rplD, 50S ribosomal protein L4; Provisional.	4.7637e-102
NC_015501.1|WP_004331535.1|458585_459428_+|fumarate-hydratase	gnl|CDD|180486	PRK06246, PRK06246, fumarate hydratase; Provisional.	7.21566e-174
NC_015501.1|WP_004331517.1|434710_435016_-|30S-ribosomal-protein-S10	gnl|CDD|179076	PRK00596, rpsJ, 30S ribosomal protein S10; Reviewed.	6.60044e-60
NC_015501.1|WP_013759957.1|450792_452940_+|hypothetical-protein	gnl|CDD|275380	sd00033, LRR_RI, leucine-rich repeats, ribonuclease inhibitor (RI)-like subfamily. A leucine-rich repeat (LRR) is a structural protein motif of 20-30 amino acids that is unusually rich in the hydrophobic amino acid leucine. The conserved eleven-residue sequence motif (LxxLxLxxN/CxL) within the LRRs corresponds to the beta-strand and adjacent loop regions, whereas the remaining parts of the repeats are variable. LRRs fold together to form a solenoid protein domain, termed leucine-rich repeat domain. Leucine-rich repeats are usually involved in protein-protein interactions.	3.58235e-23
NC_015501.1|WP_004331550.1|431995_432259_-|30S-ribosomal-protein-S19	gnl|CDD|178985	PRK00357, rpsS, 30S ribosomal protein S19; Reviewed.	3.4077e-59

Protein sequences

>NC_015501.1|WP_004331537.1|438027_438405_-|30S-ribosomal-protein-S12
MPTIQQLVRKGRETFEEKGKSPALGSCPQRRGVCVRVYTTTPKKPNSAMRKVARVRLTNGKEVNAYIPGEGHNLQEHSIVLVRGGRVKDLPGVRYHIVRGALDTAGVDGRRQRRSKYGAKRPKAK
>NC_015501.1|WP_004331548.1|437179_437656_-|30S-ribosomal-protein-S7
MRKAKPKKRQVLPDPVFGDRQVTKFVNHLMYDGKKSLAYSIFYRALDIVKDKMSQEEKSALEIWKAALDNVTPHVEVKSRRIGGATFQVPTEIRPERRESISMKNLIIFARKRGGKTMADKLAAEIMDAYNSQGGAFKRKEDVHRMAEANRAFAHFRF
>NC_015501.1|WP_013759951.1|435034_437158_-|elongation-factor-G
MSAIHSKLEQTRNIGIMAHIDAGKTTTSERILFYTGLTHKIGEVHDGAATMDWMAQEQERGITITSAATTTFWTYGDKKYKINLIDTPGHVDFTVEVERSLRILDGAVATFCAVGGVQPQSETVWRQADKYKVPRIAYINKMDRSGANFYEVQRQMVDMLGAKACPIQIPVGEEDSFKGVIDLITMKAIIWHDETMGAEYEIDEIPDDLRADAEEWRDKLLETLAETDETLMEKYFDDPSTITEDEIRTAIRTATLAMEIFPMLCGSSFKNKGVQTLLDAVCAYLPSPVDTPEVVGHALDSDKEEVREVDPDAPMSALAFKIATDPFVGRLCFFRVYSGHIDAGSYVFNSRSGKKERISRLFQMHSNHQNPMETIGTGDIGAGVGFKDIRTGDTLCDENAPLVLESIDFPDPVIGIAVEPKTQKDMDRLGVGLAKLAEEDPTFVVKTNEETGQTVISGMGELHLDIIIDRLKREFKVECNQGQPQVAYKEAVTQTVDLREVYKKQSGGRGKFADIIIKFGPADEDFDGTLQFVDEVKGGNIPKEFIPSVQKGFEKAMKSGVLAGYPLDRLKVTLVDGSFHPVDSDQLSFEVAAMMAFKEASEKASPVLMEPIMQLEVVTPEENMGDVIGDLNKRRGQVEGSEVNRSGAQVIKAKVPLSEMFGYVTALRTITSGRASSTMSFSHYAEVSSSIAKKILEELNGRVDLIK
>NC_015501.1|WP_004331517.1|434710_435016_-|30S-ribosomal-protein-S10
MSQKIRIKLRSYDHMLVDKSAEKIVTAVQNTNALVSGPIPLPTHKRIFTVNRSTFVNKKSREQFELNAHKRLIDIYNASAPTIDALMKLEMPSGVDIEIKY
>NC_015501.1|WP_004331549.1|434071_434689_-|50S-ribosomal-protein-L3
MPGLLGKKIGMTSVFSAEGVNVPCTVIEVGPCVVTQVKTADRDGYEAIQLGFQDAKDKHTTRPLQGHFKAAGVTNKRHLAEFMGFGSDYKLGDEITVELFNDTHYVDVHGTSKGKGFQGVVKRHGFGGVGQSTHGQDDRLRAPGSVGACSYPAKVFKGTRMAGQLGNKRVTVQNLEVIKVMPEHNILVLKGSVPGAKGSIIAIEK
>NC_015501.1|WP_013759950.1|433448_434072_-|50S-ribosomal-protein-L4
MELSIYNIQGEDTGRKIALESSVFGIEPNDHAIYLTVKQYRANQRQGTHKTKERSEMSGSTRKLFRQKGTGGARRGDINSNILRGGARVFGPRPRSYSFKLNKKLRQLARRSALTYKAQDNQIMVLDQLSFEAPKTKSFVSMAKALNVDGQKTLYVVSQIEDTVALSARNIPGVSIVRAQDLNTYCVLDCRKIVFTEDALAQVNEMF
>NC_015501.1|WP_004331538.1|433127_433421_-|50S-ribosomal-protein-L23
MGIIIKPIISEKMTAITESNPQRYAFLVAPTANKIEIRNAVEKMYNVKVDSVNTCRYDGKRSSRYTKSGVITGRKPAFKKAFITLQGEDTIDFFSNI
>NC_015501.1|WP_013759949.1|432290_433124_-|50S-ribosomal-protein-L2
MGIRKLKPATPGQRHKTIGAFDAITASAPEKSLVVGARKSGGRNNTGKMTIRNVGGGHKRKYRIIDFKRTKDGIPATVKSIEYDPNRSSRIALLYYADGAKNYIIAPNGLTVGQQVMSGENATPEVGNALPLAKVPVGMIVHNIELRPGQGGKLVRSAGAFAQLVAREDNYVVLRMPSGETRRILAACKATIGSVGNSDHALERSGKAGRTRWLGRRPRVRGVAMNPVDHPMGGGEGRASGGHPRSRTGLYSKGLKTRAPKKHSSKYIIERAAKRKK
>NC_015501.1|WP_004331550.1|431995_432259_-|30S-ribosomal-protein-S19
MSRSLKKGPFISVKLEKKVLAMNESGKKSVIKTWSRASMISPDFVGHTIAVHNGKSFIPVFITENMVGHKLGEFAPTRTFRGHSGNR
>NC_015501.1|WP_004331543.1|431540_431954_-|50S-ribosomal-protein-L22
MSANNQDTIETTAQETVTQPAVAKLRNVPTSPRKMRLVVDNIRGMEVERAMATLRFSSRRVAAQRVEQLIRSAVSNWEQLNGRKADEGELYVSKIYVDEGVTLKRLRPAPQGRGYRIRKRSNHITVWVDQIVNNVAK
>NC_015501.1|WP_004331526.1|440026_440653_-|HAD-family-phosphatase
MIDTLVFDFGGVLVDLQPEVSLRRFRELGVQDIDEMLNPYRQLGVFHDLEMGLVGREEFVARLNEHAGTDLTDEQINEAILLFLKGVPQYKFDCLEQLRKKYKIYILSNTNPYIMAYAHSPHFLPATGRTLSDYVDKVYASCEMQTMKPDRAIYEQMIADSGMVPERTLFIDDSTANLEAAAALGLQTLLAVNATDWRPALAARLQHD
>NC_015501.1|WP_013759953.1|440659_442657_-|S9-family-peptidase
MTAQQGSKQMTPEMLLTMPRVGSYALAPDGKQVIYNVSQPSIKDNNSRTSIYLINSDGSGRTELTAPSAGSEYTPRWSRDGKQIYFMRGTDQGMQLFARTLSDGVERQLTAIDGGIVDYLFSPDETTLLYVQDIKARPVVTDVYPDLDKADARIIEDLMYKHWDEWVSTMPHPFIAKVTAQPITKGLDLLEGEPYEAPMRPFNGIEDIAFSPDGNLIAYACRKKTGLEYSLSTNSDIYLYNVSTGETTNVSEGIMGYDTHPVFSPDGRSLIWIGMEHDGYESDLQVMYLYDLAKKQYRPLTADFEYNIANPTWSADSKTIYFITCREALTHLYSYQLANGKIKQITDGQYDYTGFDMNAEGVCVASRQSMTYPTELYMVNLKNGKATALTEEDKPIMSQLGDLTCEKRWMPTTDGGKMLTWVLYPPHFDKSKQYPSILYCQGGPQSTISQFWSYRWNPRIMAEQGYIVILPNRHGVPGFGKAWNEQISGDYSGQNIRDYLTAADLMKQEPFIAPDRMGAVGASYGGYSVYYLAGVHEGRFAAFIAHAGIFNLEAQYLETEEKWFANWDMGGAPWEKDNATAQRTFANSPHKLVDKWDTPILIIHGEYDFRILASQGMMAFDAAKMRGIPTKMLLFPEETHWVLKPQNALLWQRTFFDWLDRWLKK
>NC_015501.1|WP_013759954.1|443523_445137_+|leucine-rich-repeat-domain-containing-protein
MKKLLPTLLCLLALFSLPMYGQESVIKLTTHMKPTDRFNISIKCDGTPKVEGASGMESGGSPMWDGSVNYQLSVKQPELTITGTNITLCTIGQDSIYSLDVTGCPTLEELTCPGNYLTEIDLSKSVKLKTFICYNNDITSIDLSNCPELYQFDCNANPITAIDLKANSELTFLTCGSTKVQKLDLSGCTKLEELIAPNTSVEEIDLSGLSYLTEVNCNQNSNLRKLTLAGNTALRNLEAGNCAIEQIDLSEATALTYLILSNNQLSTFTASNPSVETIDLRNNKLQEITLPECKNLQSVTLYNNFIKGAAMTAFMNSLPEAKKSSYFRAPKIELITTDNAQERNICLVSDVKIATDKGWEVFGNSESTSTVSPYAGAALYPVTLEVAKHGKAQLTGADDLTAIPERTELKLTMTPDEGYVVDRVYCNHELLEVDGNEMTIVVREETLVEVFFKDPLSINPIEDSAQVKLFPTVADQLLTVTGLMPQEQISIYTLSGVRLATIEADLQGTVSVDLSTYSEGGYLLQHQGGAARFVVKH
>NC_015501.1|WP_044211177.1|445140_446199_+|leucine-rich-repeat-domain-containing-protein
MRQLKDMKRLPLLLSTFLLCSALSGAAQTQTAPYAGNAQIVIATDAAVGDKLKVLIESPAGAENVWIDLNNNGVCDPGERYEYVQYRYNSFTISSREQITIHGEISYLDLSSNKLTKLDLTAASKALAALYAHHNQITELDIAGMSSLNLLSLDFNQLTQLDVSSNEKLLMLSATDNALESVTLPSGTSALINRVYLYNNRLSSETIHKLIERLPQRQVTNKARIYLLDSTSPTEQNKCAPEDVALANQRAWDIYDWLGGENEGRNPYAGSHVGTTPTYSSVAPRPHIVVTEQGIELSELAPGIHIELCSMSGISVASAESDGTGYAEIPTSLLPQGVYLLLSADWCERLLL
>NC_015501.1|WP_044211179.1|446424_450501_+|T9SS-type-A-sorting-domain-containing-protein
MPTLRKKLIYTLNLVQAMKRLLPILLCFLAFAVPRVYGQKTYPVTFSAMEGGTIRATVVSPWETITSGQNVSAGLDVNFYAEANEGYQLDYWEVNGERNDLTDYTLPTENLQAPLNVVAHFKTAPADGYAVHFSVVGEGSIKASYLATSGWGNTDVKDGDMVPAGTRVSFEVSPKGDKDVGHWTINGKKDNDSYGKKEVVYTVIAETTLSVEVIDPVYDQLTYEATEGATLEAYFNWSPINSGDSVKRGSAVTFTPRFEDAYKLDHWEINGSLYPQSANGSSIEYKIMDKTHVKLFARMKDQLTINFSAEANGEVVGFKKESSSYNATFAEVASGEKLYEESQVILLAKPSEGYHLVGWTLAGDTIGKESPLIYKVKEGDNTIVAHFAAGADTETIPVHFSSSDGGKVTGKMSLYSPYYTQVPVKDGYPIAKGSSIDFTAVPDSLYMVKSWSVNGKSDEFYNGKKEFSHSFYSEDTLYVEFNQFTPRVVTFEASPAEGGRVDVKDSYWENVTSGGIVPDGSKISIYAYKEDGYAFDYWEIDGVRSTAYETSKIYDYVVTADVAFKAIFKKLAVLPVTFSATGAGSVTGKIGYWGDQINSGDSIQEDTSLRFTATADAGAKLLNWTINSVDTLAGQTDISYYVRPDKANTIVANFVSTTAPKAVVTFTYDGEGALACTDKLDNTPIASGDSIAIGNTLQFVATPSTGYSVSGWTINGEELFPGQTTIEYTVVEGTNDIKAHFKEGAATEGHLVTFFATPNEGGVVTATYFGEGYTLVPFNSGDRVKESSWLTFTAKANEGYELEKWIVDGEEQPLDDSTPNQYIHTIHADLTVEAVFKQNTPAPSKVTLTYGVATEGGKLSVLAYPATGDPYTVNSGDEVDYATNLFFQAEADPGYTVEKWTVNGKEDTFAGNDNMLSMAIQKNSDVQVYFKKADDTNDGYTVTFAADPFECGIVTATYAEGFSNVDIVSGNKVPEGKYVTFKAEAYAGYEFEKFTVNGLDAPVDFTNPEQYATELTGDLNVVAIFKGSTPVEEHTVTFAADPTEGGTVTATYYDNDKEEEVPFETGAKFTGDETYLTFTAKANDGYKIVSWIANDEDVTPSNPTVYEHQLKADLDLKVVFKKVYPLTLTATKGGSLAAKVGDKELKSGDNVTEGTKVTIEATPETGYELTALTAGSEDILATKSFEMKGATEVKATFTKLQKNYVVTLQSNEHGTISIQEKVDLKAVPEGTKLTVVAKGANDKCELTKLTANGKDILKDMTFTVTEDMTVVAEFVDHTGLEAATTATLSLYPNPAKEYAIVAGLAPEATVALYTLEGQLITRLRADRSGSLQIDLTALSDGTYLVVTESASQRLVIKH
>NC_015501.1|WP_013759957.1|450792_452940_+|hypothetical-protein
MRKRITPLLLLLLILCCPSMSHALERQPAPISTLRDASEPTIRLTTSGEIGTNYSFTIIGGTTPIQIDWGDGTLVSPTATMVKGQKAGEEIKIYGDCLSFLATGAKITAITIDAPSMGMLSLADNELTTLDLSKTPAIESLNLQNNHLTSLNVHGLTSISTLNVKLNQLATLDLSGLNTLRTLIVSDNPALTSLEVSTLTSLSSIRADNCALEQIALPASITEFYAKGNKLTTLGEETLSLAKLKRLRVPNNQIAQVTLGECPLLNDLELDGNQLTSLTLGSLPALRTLYLQSNQLDAEALNKIYTALPTAEGTIKVSGNAGAEAAAGYIAIDKGWKIDIPGQKSQTTDPCITIRVKPDKDVYLGLAGFASDSKVKVETDEGVILEKVIPSGVPSIEKYQSKRGMIRIIGLVHTIDSSENGGRVYDIDASQSPKLVRLFALHNTMTSINVKGCSELTFINCAGSELPALDLSDCTELETAWLPGNHMTTVDLTGLTKLKEVSLERNSLSEIKGLSDCTQITELDVAENQLTTLSLEGLSRLETLDCRENLLTALDLNPCPALKEIFCYKNAINAQAMKQLFESLPARSAGERGELYAINSADNGEENQVNSADVKIANNKSWLVYDYKGYENSGKNPLANERIATAKSYQLQLTRDYIEIIYAAPHAEVALYTAGGMLLQRARTDLMGSLQLSVAELPAGSYLLTIGGEVTKVMR
>NC_015501.1|WP_155811456.1|453064_454207_+|T9SS-type-A-sorting-domain-containing-protein
MTAQWSHILTKPIYHTMKRLLPIWLCLLALAVTQLYGQQRSLQQAVESDMYTVTFFATPTEGGTLTAVYFDENSRLVTLQSGEQIVEYTGLYITAKPSDGYKLEKWIVNGDELPLNADRPLDYSCRVEEDLIVEAVFKDLNPEPKTFELTLTPSEGGKIIAKADGSEITDLTHVAQGTIVTIEATPEIGYELTALTAGSEDILATKSFEMKEDTEVKATFTKLQKNYVVTLQSNEHGTISIQEKVDLKAVPEGTKLTVVAKGANDKCELTKLTANGKDILKDMTFTVTEDVTVVAEFVDHTGLDAATAATLSVYPNPAKEYAIVAGLVPKATVALYTLEGQLITRLRADRSGSLQIDLTALSDGTYLVVTESASQRLVVK
>NC_015501.1|WP_013759959.1|454446_455130_+|PorT-family-protein
MKKVILSLVTLLAATTLATAQMRPTIKVEAGANFANQTTKVNDKSTDGKMMIGYRVGVGAEFGFAEGFYVNPGLYFLSRGAKSEGIELLGAKADATLWLHNVEVPVHVGYRAGIAPDMAVSIQAGPWFSYGFLGKRVYKATGEGLAADAAKKIVDELNKGDNNPYKDGKAVKQSLKPFDLGVGMQAAFEYRQFGVNLGFEYGLLNTSNVENVKVNNMNFYVGLGYRF
>NC_015501.1|WP_013759960.1|455228_455933_+|PorT-family-protein
MKKVILSLITLLAATTLATAQMRPTIKVEAGANFSNMTGKANGETNDGDILTGYRVGAGVEFAISDGFYINPGLYFLSRGTKATVELPKMTDYAMKVVSSTWLHNVEVPVHVGYRVAVAPDMAVSIQAGPWFSYGFLGKVSQKTSVTGEGKIADAAREMAKAADDAVNKGENNPYKTDPKVLKPFDLGLGLQAAFEYRQFGVNLGFEYGLLNTSAFDEVKVNNMNFYVGLGYRF
>NC_015501.1|WP_004331535.1|458585_459428_+|fumarate-hydratase
MRTISSTAITDLVEKLCIEACVNLSPDIEAAMQQGAERDRSPLARNVLSTIIENVHIARSERAPMCQDTGMTVIFVDMGQDLHVEGDLIEDAINEGVRRGYTHGYLRKSVVSDPIHRHNTGDNTPAVIHYRIVPGDQMHITVAPKGFGSENKSALSMLTPSQGVAGIKQFILDTISHAGGNPCPPIIVGIGIGGTMERSAELAKRALLRPIGERHPDPAVAEIEEELLQEINKMGIGPAGFGGDTTALAVAINTGATHIAGLPVAVNISCHATRHAEGVL

Crispr_ID: NC_015501_3

• CRISPR_ID: NC_015501_3
• CRISPR_location: 632317-632455
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_015501_3

Consensus_repeat	Method
CCCACGTGGATATTTTTTATTCTCCACGTGG	CRISPRCasFinder

spacers of NC_015501_3

>3.1|632348|77|NC_015501|CRISPRCasFinder
ATATTTTTTATTCTCCACGTGGAGGCGAAACGATTCCTCCGAAGTTTCATTTGATTCCTCCGAAGAATTTTTTCTCG

CRISPR arrays and Neighbor proteins around NC_015501_3

CRISPR arrays

The CRISPR arrays of NC_015501_3

>merge|NC_015501|3|632317-632455|CRISPRCasFinder
TCCACGTGGAGAATTTCAAATCCCCACGTGGATATTTTTTATTCTCCACGTGGAGGCGAAACGATTCCTCCGAAGTTTCATTTGATTCCTCCGAAGAATTTTTTCTCGCCCACGTGGATATTTTTTATTTTCCACGTGG

>NC_015501|3|3|632317-632455|CRISPRCasFinder
TCCACGTGGAGAATTTCAAATCCCCACGTGG	ATATTTTTTATTCTCCACGTGGAGGCGAAACGATTCCTCCGAAGTTTCATTTGATTCCTCCGAAGAATTTTTTCTCG
CCCACGTGGATATTTTTTATTTTCCACGTGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015501.1|WP_013760079.1|650747_651404_+|orotate-phosphoribosyltransferase	unknown	unknown	gnl|CDD|234771
NC_015501.1|WP_013760063.1|620498_622061_-|DUF4301-family-protein	unknown	unknown	gnl|CDD|372920
NC_015501.1|WP_004330652.1|640459_642616_+|methylmalonyl-CoA-mutase	unknown	unknown	gnl|CDD|236508
NC_015501.1|WP_013760074.1|638563_640435_+|methylmalonyl-CoA-mutase-small-subunit	unknown	unknown	gnl|CDD|273191
NC_015501.1|WP_013760066.1|623727_625593_+|2-oxoacid:acceptor-oxidoreductase-subunit-alpha	unknown	unknown	gnl|CDD|274738
NC_015501.1|WP_004330658.1|629779_630757_+|YitT-family-protein	unknown	unknown	gnl|CDD|224203
NC_015501.1|WP_013760062.1|618668_620459_-|aminopeptidase-P-family-protein	unknown	unknown	gnl|CDD|238518
NC_015501.1|WP_013760076.1|644400_645510_+|hypothetical-protein	unknown	unknown	unknown
NC_015501.1|WP_179943720.1|637602_638394_+|LPS-export-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|213185
NC_015501.1|WP_044211216.1|646831_650473_+|hypothetical-protein	unknown	unknown	unknown
NC_015501.1|WP_013760067.1|625608_626652_+|2-oxoacid:ferredoxin-oxidoreductase-subunit-beta	unknown	unknown	gnl|CDD|237006
NC_015501.1|WP_013760068.1|626882_629699_+|leucine--tRNA-ligase	unknown	unknown	gnl|CDD|178177
NC_015501.1|WP_013760070.1|631179_632256_+|phosphatase-PAP2-family-protein	unknown	unknown	gnl|CDD|239488
NC_015501.1|WP_013760075.1|642862_644215_+|hypothetical-protein	unknown	unknown	unknown
NC_015501.1|WP_013760064.1|622528_623350_+|glycogen/starch-synthase	unknown	unknown	gnl|CDD|377972
NC_015501.1|WP_004330670.1|618099_618663_-|gamma-carbonic-anhydrase-family-protein	unknown	unknown	gnl|CDD|100051
NC_015501.1|WP_013760072.1|632849_635363_+|TonB-dependent-receptor	unknown	unknown	gnl|CDD|379720
NC_015501.1|WP_013760073.1|635907_637587_+|putative-transporter	unknown	unknown	gnl|CDD|179654
NC_015501.1|WP_013760077.1|645715_646618_+|FimB/Mfa2-family-fimbrial-subunit	unknown	unknown	gnl|CDD|370149
NC_015501.1|WP_013760069.1|630775_631162_+|DUF2752-domain-containing-protein	unknown	unknown	gnl|CDD|378499

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015501.1|WP_013760079.1|650747_651404_+|orotate-phosphoribosyltransferase	gnl|CDD|234771	PRK00455, pyrE, orotate phosphoribosyltransferase; Validated.	6.154e-69
NC_015501.1|WP_013760063.1|620498_622061_-|DUF4301-family-protein	gnl|CDD|372920	pfam14134, DUF4301, Domain of unknown function (DUF4301). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 505 and 516 amino acids in length.	0
NC_015501.1|WP_004330652.1|640459_642616_+|methylmalonyl-CoA-mutase	gnl|CDD|236508	PRK09426, PRK09426, methylmalonyl-CoA mutase; Reviewed.	0
NC_015501.1|WP_013760074.1|638563_640435_+|methylmalonyl-CoA-mutase-small-subunit	gnl|CDD|273191	TIGR00642, mmCoA_mut_beta, methylmalonyl-CoA mutase, heterodimeric type, beta chain. The adenosylcobalamin-binding, catalytic chain of methylmalonyl-CoA mutase may form homodimers, as in mitochondrion and E. coli, or heterodimers with a shorter, homologous chain that does not bind adenosylcobalamin. This model describes this non-catalytic beta chain, as found in the enzyme from Propionibacterium freudenreichii, for which the 3-dimensional structure has been solved. [Central intermediary metabolism, Other].	0
NC_015501.1|WP_013760066.1|623727_625593_+|2-oxoacid:acceptor-oxidoreductase-subunit-alpha	gnl|CDD|274738	TIGR03710, OAFO_sf, 2-oxoacid:acceptor oxidoreductase, alpha subunit. This family of proteins contains a C-terminal thiamine diphosphate (TPP) binding domain typical of flavodoxin/ferredoxin oxidoreductases (pfam01855) as well as an N-terminal domain similar to the gamma subunit of the same group of oxidoreductases (pfam01558). The genes represented by this model are always found in association with a neighboring gene for a beta subunit (TIGR02177) which also occurs in a 4-subunit (alpha/beta/gamma/ferredoxin) version of the system. This alpha/gamma plus beta structure was used to define the set of sequences to include in this model. This pair of genes is not consistantly observed in proximity to any electron acceptor genes, but is found next to putative ferredoxins or ferredoxin-domain proteins in Azoarcus sp. EbN1, Bradyrhizobium japonicum USDA 110, Frankia sp. CcI3, Rhodoferax ferrireducens DSM 15236, Rhodopseudomonas palustris BisB5, Os, Sphingomonas wittichii RW1 and Streptomyces clavuligerus. Other potential acceptors are also sporadically observed in close proximity including ferritin-like proteins, reberythrin, peroxiredoxin and a variety of other flavin and iron-sulfur cluster-containing proteins. The phylogenetic distribution of this family encompasses archaea, a number of deeply-branching bacterial clades and only a small number of firmicutes and proteobacteria. The enzyme from Sulfolobus has been characterized with respect to its substrate specificity, which is described as wide, encompassing various 2-oxoacids such as 2-oxoglutarate, 2-oxobutyrate and pyruvate. The enzyme from Hydrogenobacter thermophilus has been shown to have a high specificity towards 2-oxoglutarate and is one of the key enzymes in the reverse TCA cycle in this organism. Furthermore, considering its binding of coenzyme A, it can be reasonably inferred that the product of the reaction is succinyl-CoA. The genes for this enzyme in Prevotella intermedia 17, Persephonella marina EX-H1 and Picrophilus torridus DSM 9790 are in close proximity to a variety of TCA cycle genes. Persephonella marina and P. torridus are believed to encode complete TCA cycles, and none of these contains the lipoate-based 2-oxoglutarate dehydrogenase (E1/E2/E3) system. That system is presumed to be replaced by this one. In fact, the lipoate system is absent in most organisms possessing a member of this family, providing additional circumstantial evidence that many of these enzymes are capable of acting as 2-oxoglutarate dehydrogenases and.	0
NC_015501.1|WP_004330658.1|629779_630757_+|YitT-family-protein	gnl|CDD|224203	COG1284, COG1284, Uncharacterized conserved protein [Function unknown].	2.70633e-45
NC_015501.1|WP_013760062.1|618668_620459_-|aminopeptidase-P-family-protein	gnl|CDD|238518	cd01085, APP, X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide.	1.24995e-125
NC_015501.1|WP_179943720.1|637602_638394_+|LPS-export-ABC-transporter-ATP-binding-protein	gnl|CDD|213185	cd03218, ABC_YhbG, ATP-binding cassette component of YhbG transport system. The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in cell envelope during biogenesis. YhbG is the putative ATP-binding cassette component and YhbN is the putative periplasmic-binding protein. Depletion of each gene product leads to growth arrest, irreversible cell damage and loss of viability in E. coli. The YhbG homolog (NtrA) is essential in Rhizobium meliloti, a symbiotic nitrogen-fixing bacterium.	1.95915e-151
NC_015501.1|WP_013760067.1|625608_626652_+|2-oxoacid:ferredoxin-oxidoreductase-subunit-beta	gnl|CDD|237006	PRK11867, PRK11867, 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed.	6.44873e-143
NC_015501.1|WP_013760068.1|626882_629699_+|leucine--tRNA-ligase	gnl|CDD|178177	PLN02563, PLN02563, aminoacyl-tRNA ligase.	0
NC_015501.1|WP_013760070.1|631179_632256_+|phosphatase-PAP2-family-protein	gnl|CDD|239488	cd03394, PAP2_like_5, PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.	3.39087e-23
NC_015501.1|WP_013760064.1|622528_623350_+|glycogen/starch-synthase	gnl|CDD|377972	pfam08323, Glyco_transf_5, Starch synthase catalytic domain.	4.65963e-51
NC_015501.1|WP_004330670.1|618099_618663_-|gamma-carbonic-anhydrase-family-protein	gnl|CDD|100051	cd04645, LbH_gamma_CA_like, Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Gamma CAs are trimeric enzymes with left-handed parallel beta helix (LbH) structural domain.	2.56884e-69
NC_015501.1|WP_013760072.1|632849_635363_+|TonB-dependent-receptor	gnl|CDD|379720	pfam14905, OMP_b-brl_3, Outer membrane protein beta-barrel family. This family includes proteins annotated as TonB dependent receptors. But it is also likely to contain other membrane beta barrel proteins of other functions.	2.08942e-72
NC_015501.1|WP_013760073.1|635907_637587_+|putative-transporter	gnl|CDD|179654	PRK03818, PRK03818, putative transporter; Validated.	0
NC_015501.1|WP_013760077.1|645715_646618_+|FimB/Mfa2-family-fimbrial-subunit	gnl|CDD|370149	pfam08842, Mfa2, Fimbrillin-A associated anchor proteins Mfa1 and Mfa2. This family of proteins may be lipoproteins principally from bacilli. They are between 300 and 400 residues. Many Bacteroides-like bacterial species, including Porphyromonas gingivalis, the causal agent of periodontal infection, carry at least two types of fimbriae, namely FimA and Mfa1 fimbriae, following the names of their major subunit proteins. Normally, FimA fimbriae are long filaments that are easily detached from cells, whereas Mfa1 fimbriae are short filaments that are tightly bound to cells; however, in the absence of Mfa2 protein, the Mfa1 fimbriae are also very long and are not attached. Mfa2 and Mfa1 are associated with each other in whole P. gingivalis cells to the extent that Mfa2 is located on the cell surface and probably associated with Mfa1 fimbriae in such a way that it anchors the Mfa1 fimbriae to the cell surface and regulates Mfa1 filament length.	3.61709e-39
NC_015501.1|WP_013760069.1|630775_631162_+|DUF2752-domain-containing-protein	gnl|CDD|378499	pfam10825, DUF2752, Protein of unknown function (DUF2752). This family is conserved in bacteria. Many members are annotated as being putative membrane proteins.	2.22785e-13

Protein sequences

>NC_015501.1|WP_013760070.1|631179_632256_+|phosphatase-PAP2-family-protein
MRLFTLFTLALLLLLSPYSRTLAQSSSSDTLAPSPDPLSVLLPGGIFAAYPLHHSDVAIRTTRHSLLGARWRNPYDDHMQFASYGLQLAMRCGGATGRSRTWGEMLTADGIAALGTAAIVLSVKKGVHRMRPDGSTANSFPSGHTATAFLGAELFNLEYGADYPLLARLQYIFATSVAFGRMANNRHWYSDVLWGGLIGVSMAHVGYLVSDLIFGRYIPAVSPEIPDNYFYLSLLCSRHLSGGFGCIGAQIGWQTSSLNYAAEVSLRPDKEHPTLHGDLLVGMPLYQWRYLELRHSYGIGIGYDKATREHSYTHLQAGLEAHPRLHYLDKLGLFLRLHCEPYRQSYLTLGVLLRHRGW
>NC_015501.1|WP_013760069.1|630775_631162_+|DUF2752-domain-containing-protein
MLATSRHNKALLALLCCMLVGGVVLYLYSPESLQIPRCPFLQLTGWQCPGCGSLRGIHALLHGDLGRVLQLNVMLIPALLYLALLVLLELTRPQSMRAERLYHRFSGRTASWIIFALIIVWGVGRNFL
>NC_015501.1|WP_004330658.1|629779_630757_+|YitT-family-protein
MTQALAAPNSKQAKAWYFVHDFFFIVLGVCLYVLGWAGFILSQEIATGGLAGVTTIIQIATSIPAFIPYNIINVGLLLVSIIFLGWRYSVKTLIGVILMGIAIPIGQALFGDPNTEVYHNLSHWLTDNIPNVGPLLREERFMAVIIGGILCGSGLFLVFHVNGSTGGTDVIVSIFNKYTTLSLGRAMILIDATIVITSYFVNVYVSGKDPQLGAELLTFSIVEVVFCAMTLDYWTNSNKHSIQLFIFSKKYKEINEAITQRLHRGCTLVHADGGYSQEEMRILMVVTRKAQLQSINRIIKEIDPDAFVSEGTVHGVYGRGFDNLK
>NC_015501.1|WP_013760068.1|626882_629699_+|leucine--tRNA-ligase
MDYNHHDIEQSAQRIWQDADIYRVEIDRDKPSYYVLDMFPYPSGAGLHVGHPLGYIASDIYARYKRLQGYNVLHPMGYDAFGLPAEQYAIQTNRHPEETTRVNIARYREQLDNIGFGFDWSRQVVTCDPEYYKWTQWTFVQLFHHYYDTATDRAESIDKLVKHLEAHGTEGCTAYSSTPLELTAEEWRAASEAEQSEWLMHYRLAFLGESVVNWCPELGTVLANDEVSDGVSERGGYPVVQRKMKQWSLRVSAYAERLLAGLDQLDWSDALKEMQRNWIGKSVGASVTFKASTAHGELPIEIFTTRPDTLYGVTFMVLAPESSLVAELTTEEQRAAVEAYLDRTKRRTERERQADHSVTGVFTGSYAQHPLTGEQIPIWISDYVLAGYGTGAIMAVPAHDSRDFAFARHFDLPIRQVVLPKGGEASDPSTWSESLDSKEGELINSPLLDGKPVAEAIDYMCHYLDERGLGKKRINYRLRDAIFSRQRYWGEPIPIYYKEGVPHTLPLDKLPLTLPEVDKYLPTESGEPPLGRAKHWCTEEGYPYELCTMPGFAGSSAYYLRYMDPQDKSALVSPEANSYWRQVDLYIGGTEHATGHLIYSRFWNKFLYDLGVVCEDEPFKRLVNQGMIQGRSNYVYRIKGTNQFVTYSQREQYDVTQMHVDIHLVQNDILDQEAFRQWRDDLHDATFITEADGSYLCGFAVEKMSKSMFNVINPDEIIEQYGADTLRMYEMFLGPLEQSKPWDTNGIDGVYRFLKRVWSLYHDGEGQLTVSASAQASREELRTIHKLIQKITQDIERLSFNTSVSAFMIAVGELQKAQTTSLEVLRPLVILLSPFAPHIAEMLWQEMRSVCSSETLSSESIVTAAWPQCDESLIAEDSVRYPVSFNGKVRFNLELPAGLSKEQIQEQVLAHADTIKWIDGKPLKKVIVVPGRIVNIVL
>NC_015501.1|WP_013760067.1|625608_626652_+|2-oxoacid:ferredoxin-oxidoreductase-subunit-beta
MIETNSNLEKGTLRFAPKDFKNASPVKWCPGCGDHGVLAAVHKAMAELDIAPDETVVVSGIGCSSRLPYYMSTFGFHTVHGRGAAVATGVKVARPDLTVWLMSGDGDSLAIGGNHFIHAVRRNVDINEVLFNNRIYGLTKGQYSPTSPRGLVTKSSPYGTVEDPFEPAELVMGARGNFFARSLDVDQPTLTACLIAGAKHKGFAVTEVLVNCMIFNNGAHAAISDRAVRADKTIVLQHGEKMLFGEDKQRGLVLDGFKLRAVTIGEDGYTLDDVLTHDAHEPNPFLHMMLAAMNGADGLPVAMGVIRDVEGPTYDWAVHDQIDQQKAKNKVRTLRELLMTEDTWEIK
>NC_015501.1|WP_013760066.1|623727_625593_+|2-oxoacid:acceptor-oxidoreductase-subunit-alpha
MTDKPNKRIIEEVVVRFSGDSGDGMQLTGSIFSDMSAMYGNSVSTFPDYPAEIRAPQGTLGGVSGFQVRIGHDQVHTPGDYADVLVAMNAAALKVNVKNLRHDSIVIIDSDSCGEKDLKKALYQTDDPIKELGLNPDRVLACPISTMVQEVLKDIDMDARGRLRCKNMFALGIVSWLFDRPLEQAEHFISKKFAKKEIIRQANIAALHGGYSYAANTHASVGTPFVIEGAPQEAGVYLDVTGNKATAFGLIAGAERAGLKLFLGSYPITPATDILHFLAKYKSLDVITMQAEDEIAGICTAIGASYAGRLGVTSTSGPGVALKSEALNLAVIAELPLVLVDVQRGGPSTGMPTKSEQTDLLQAMYGRNGESPMVVIAPTSPSKCFDAAYYAAKIAVEHMTPVVLLSDAYLGNGSVAWRIPDYEQYPEIKPHYVDQYKGEEPWLPYMRDPETLVRYWSVPGAGSLPYRTGGLEKDNKTGAISTDGPNHELMVLQRHNKIQHIAEVIPPLTVEGDVEDAELLIVGWGSTYGHLSDACRTLQKKGHKVAHTQFTFINPMPKNTEEILRRYPRVVVAEQNLGQMAMLLRNKVSDANIYQYNQVQGQPLKVGNLVTAFEEILAEQL
>NC_015501.1|WP_013760064.1|622528_623350_+|glycogen/starch-synthase
MAAKDKKVLYISQEIYPYLPESDLAHVARYLPEHIQNAGHDVRIFMPRYGLVNERRNQLHEVIRLSGINVIVDDYDHPLVIKVASIPSTRIQVYFIDNSDLFGRKSLFGPASEGAPSDNADRSIFFIRGVFEAIKNLRWIPDLIHCLGWFSALAPVYLKTAYKDDPYFERAKVIFSVDGNEEEGVIGDDLIKKLEFDKITGDMLAPLQGEVTPDALRRMAIHYSDGVILGQEKVSPELIEYLRSEPDHKVLEYPGPAAEHPEAYVDFYRSFTE
>NC_015501.1|WP_013760063.1|620498_622061_-|DUF4301-family-protein
MSDTTAFTPEDLSYLAERGISSSEAERQLKLLVDGTPYLVIVDSAKIERGIVRLATDEMVQYLDLWHDYLQKPGADVIKFVPASGAASRMFKSLYGLPKEQQISHDDLTPEQQTFVDHLESFAFYEKLSETCLRNNWRTMSKLVESEQYGTIIDNLLDTHGMSYGSLPKGMLLFHDYPNGTKRTPIEEHMVEGALYAQDIHGRVRLHFTVSPEHLEAFRSLVDRRIQSFEDLFGCRYQVTYSVQERSTDTIALDIERGTPFRRADGTLLLRPGGHGTLIGNLSRLDASVVFIKNIDNVTPDHLKSNTVLYKKLLGGILLAVRDRIFGYLQQLKRSKVNKALTEEILTFLDETLCIQIPHAELLSEEELIPKLMSKLNRPIRVCGMVRNEGEPGGGPYLVREADGTTSLQILESVQVDKNNPEALEMMREGTHFNPVDLCCYIRDYEGNPFDLHKYVNPQTAFISEKSVEGRPLKALEHPGLWNGAMHDWNTIFVEVPSDTFTPVKTVLDLLRPEHQPLAD
>NC_015501.1|WP_013760062.1|618668_620459_-|aminopeptidase-P-family-protein
MPTNSPINQRIEALRQAMRTHHIDAYIIPSGDAHLSEYTPERWKSRTWISGFTGSAGTALVTLDKSFMWTDSRYYLQATNELQGSEMTLQRGDDPDTPTIQQYLSTHLSEGAVVGVDGACYSMAEYAPLAQSLANHGIKLVSQYDLIEEVWSDRPSVPTNTFYLQDVKFSGERTRDRLQRIREAYQSYGAEAVAITMVDELCWSFNIRGNDVSYNPVGIAFGFIDNERAYLFALPEKTVPELRQILNGEGVEIRDYDTFYDFLSKLPQDLKVMVDPKRTSQRVREELGERPVITGDSVISHLKSIKNETEIAGIHRAMHRDGVALTRFFIWLEQALKKGEHVDEYSAGETLQQFRAKQEFYVSDSFGVICGYQAHGAIVHYSATPESAYKLEPKGMLLLDSGGQYIDGTTDITRTIALGPVTDQQRTDFTLVLKGHIAIATARFPKGTRGNQLDILARKALWDRGLSYGHGTGHGVGVFMNVHEGPQNIRTDNNPTPMHLHTFTSNEPGLYRADQYGIRIENLILTVEKEQTEFGTFYGFETMTLCYLDNALVDKSLLTDQEIAWYNDYQEHVYQELSPLLTPEEAEWLRNKTLPL
>NC_015501.1|WP_004330670.1|618099_618663_-|gamma-carbonic-anhydrase-family-protein
MAYQYPAGSLIPVRGFTPQLGEGTFVAEGARIIGDVVMGAGCSVWFNAVVRGDVNSIHIGNHVNIQDGCTLHTLHGRSVCEVGDYASLGHNVILHGAKVGAYALIGMGAVVMDNAVVGEGAIVAAGAVVLANTIIPPYTMYAGTPAKYIKDVPPEQSQSLNKRTAHDYGMYADWFMNPEKYSEGSHE
>NC_015501.1|WP_013760072.1|632849_635363_+|TonB-dependent-receptor
MVITHSMTTFAQQKSIEMQQVSGSVLMATNRSPVPFANVHAITQRGEQLDTLSQVSDHIGRFIFTLEEGREYRFVATFIGMECQEVTILPEEYGTDRPVVILMQESTTELDEVRVVAARPLFKVDIDRIAYSVKDDPSAQSSTLLDMLRKVPLVTVDGQDNIQVKGSSSFKIYMNGKPSKMMDQDPSTVLRSIPASLVQNIEVITDPGVKYDAEGVGAILNIVTESKEEMEGLAGSVTVGTHYTNKKVGGNGSLSLTGKKGKFGFSGSYNFNYMPHTTQTVLTTRTSDVALSHSDASTGNNAKVHMGNLSASYDISPRDLLSANLSLMRVNSLSLSKVTSHDYAPQDLTMAAPISTTTYDSSTKSLYSTIETSVDYQHSTDLQGELLTLSYRYAGNPTEADELMSINYLIPTERLLQQQTINRGNLHEHTGQIDYVRPFGQMHTLETGVKYIARLGNTDPTYLFRVGSEGEWNSGGAFDQKIASAGAMRYRQQVIGAYASYALHVGVFGFKTGVRGEYGLNNIYYPNNPSDNFKNQFLDWVPEVNLSYNFSPTQQIGFAYRFNVARPNIMQLNPTRNQGSPYEIQYGNPNLENEHRHSGTLSFSTFSNRFMLQASLIGQLCNNAIGVYNFADPSNPKLIHFTWGNIGRNWSTILTLYSSYMPTLWLRIMGGGMYGYHSFESFGKINSTANIYAWKNGGWGGQLWFQAMFTLPKSWSATLSGGYVQQGVALNMDNYNLWWNNVNISKKFLKDLLTVGAYVQNPFTPVMRLNIHGHGPGNNVTTIVSRSNFSVGINLTYNFGQMKQNVSKARHTIVNDDLSTGSNNTNGQGGGITESVK
>NC_015501.1|WP_013760073.1|635907_637587_+|putative-transporter
MDSLRAFLNELFVIPSVPQSIIVISLVSLVGLLLARIRIARISLGVTFVFFVGILLSYWGITLEARTLDFGMNFGLILFIYALGLQVGPAFFPSLKKGGIRDNLDSLLIVVVDLALVVALFFVSELPISQWVGIMSGATTNTPALAAAQSSLPSVGTEGQSMLAEMALACAITYPFGVVGVILALYVLAPLAKKRAKGQSDEEERAAFFSEYEVMNMGVVGKTISEVSRIAGTPFVISRIWRDGKAMSPDSSTQLQEGDRLLIVSDEREVPRLELFFGKKMARDWNRSDIDWDSVDQSLVSRRLVLTRKEYNGVRLSALHLRNDYRVNVTRIDRAGIELLTSPDLHLQLGDRMTVVGTKEATDAVAAKIGNEIKDLDAPNLLGLFIGLFISVFVGMIPFYIPGVSMPIRLGLAGGGIIIGILMGAFGPRMHVTTYITNSASLLVRQLGLILYLGCLGLSSGAGFFDILFSTQGLVWLGYGALLTVLPILLVGWYMLRRKRGDYATMCGVVCGSMANPMALEVVGDRLKGSRHTVAYATVYPLGMFVRIITAQLLILLFV
>NC_015501.1|WP_179943720.1|637602_638394_+|LPS-export-ABC-transporter-ATP-binding-protein
MDTAEALSPDRHKGETGLLRTEHLVKRYRSRTVVNDVSIELRQGEIVGLLGPNGAGKTTTFYMTVGLVVPNGGKIYLNEQDITKLPVYQRARLGIGYLAQEASVFRKLSVEDNIKAVLEMTPLTPDQQRERLEMLIEEFGLHKVRTNQGNRLSGGERRRVEIARCLAIDPKFIMLDEPFAGVDPIAVQDIQSIVAKLKQRNIGILITDHNVNETLSITDRAYLLFEGKVLFQGTAEQLAENALVREKYLGRDFVLRRKSFADL
>NC_015501.1|WP_013760074.1|638563_640435_+|methylmalonyl-CoA-mutase-small-subunit
MANKRERLFGDFPPVSKEQWLEKVTVDLKGASFDKRLVWRTPEGFNLQPMYRREDIAQYASRLALPGEYPYVRSTKLNNEWLVRQDIKVKDPAEANAKALDILNKGVTSLGFNISKTILSAETLETLLKGIDLTAVEINLSTCISRTVELAELFAAYVQKHQIDGAAVRGAIEYNPFKRELMKGVVDDKRYDTLEQLYNIAKPIPQMRLYIVEASMLSNAGAGIVKELAYALAWGAEVLDQMVARGHKVEEIARRIKFHFGISSSYFMEMAKFRAARWLWAEIIGAHGDQYKGDVAKICQHATTSQWNMTIYDAYVNLLRSQTETMSAALGGVDSITVLPFNIAYEESTDFSERIARNQQLLLSEESHFDKVVDPAAGSYYIETLTNVIAEQAWQLFGEISASEGGFESFVTTGALQRDLQETNTERHAAVAKRKETLLGTNEFPNFTETAHEKLATPAVITTGCGCTAGEQQEGLQPLNFDRGANQFETLRLTTERGKQPVVFMLTIGNLAMRLARSQFSGNFFGCAGYKLIDNLGFETVQEGIDAAVAAKADIVVLCSSDDEYETYAPEAFRLLDGRAQFVVAGNPACTEQLQALGIEHFIHVRSNVLETLQHFNELFGLA
>NC_015501.1|WP_004330652.1|640459_642616_+|methylmalonyl-CoA-mutase
MTKPLYKEIDLSHSQFGRTDAAKWGKEHALEANWTTPEQIKVKPVYTADDIEELEHLDYVSGLPPFLRGPYSLMYPFRPWTIRQYAGFSTAEESNAFYRRNLASGQKGLSVAFDLPTHRGYDADHPRVVGDVGKAGVSICSLEDMKVLFDGIPLAKMSVSMTMNGAVLPILAFYINAGLEQGAKLEEMAGTIQNDILKEFMVRNTYIYPPEFSMKIIADIFEYTSQKMPKFNSISISGYHMQEAGATADIEIAFTIADGIEYLRAGINAGIPVDKFAPRLSFFWGIGVNHFMEIAKMRAARMLWAKVVKSFGAENPKSLMLRTHCQTSGWSLTEQDPYNNVGRTCIEAMAAALGHTQSLHTNALDEAIALPTDFSARIARNTQIYIQKETQVCRSIDPWGGSYYIETLTDEIAHRAWEHIQEVEKIGGMAKAIETGLPKMRIEEAAARTQARIDSNQQVIIGINKYRLEHEDPIEILEIDNTSVRQSQVARLEDLRAHRDEQAVQAALKEITECVRTKQGNLLELAVKAAGLRASLGEISDACEEVVGRYSAVIRTISGVYSKESGHDKQLEYAKQLAAEFAQREGRQPRIMIAKMGQDGHDRGAKVVATGYADCGFDVDMGPLFQTPEESARQAVENDVNILGVSSLAAGHKTLIPQVIEELRKLGRPDIIVTAGGVIPAQDYDFLYKAGVAAIFGPGTPVAYSAAKCLEILLGKEA
>NC_015501.1|WP_013760075.1|642862_644215_+|hypothetical-protein
MRSRIHPNNILLLLVGMLFVVVATTSCGRSPLEGSDEELTLLIRFSPIHPFRTIEDRAQQDAYEVGAYNPITLFFYNAAGDPTEPYRVELKSAEDLAKAMGAGYEIKVRQAVSQVSAVAGRSGVLNPTALDGITIDQLQELGGADDATKSFLHSVPYVAPKTPVKALSSNKLTVELKPVPNVARLEISGNITIPTESQQTIADEIVAQRMKTYPGEGYSYVASPCELPIRYITDFTIRGIYINNYKKTPNAANKDRDSLTADKYDLIHKVWTGHNAAMHTFFVATNPYASQIAAGKVDAYQIYPGSATDPEALDHIIVEVEYKLHTRVGYFDAMVYNKDKGDYVYACSRVETKPDQKLRRFITIRKFLVTESGTDQSLVAFDPGKIYRIDLNYLSPLFSMNTKPGVTTIDESAIIIPRRERTDERPEEASAAVHVDVSGWTHINIDTELE
>NC_015501.1|WP_013760076.1|644400_645510_+|hypothetical-protein
MKYMKMAAIALMALALFSCKNKSNEPSAEASALSLRINDSQLRAIEGEVAGGTETNITENVTIKLFPSGREINLTPTQIEEAKNLTKGTRITVGEVVKQVSIVKANAEITNDTEITAWQGKADKFTTEIPLTAPETTVTPGVEGKNTVYTVELQPVPAFSRVEVAGDIEAGNSGKFPENASGKSAYKSIKVEQVYINNYLPTRAGDRVYCAGKDGKFETDPHANMCDVIADQASFKAKSKVAGYQLFPIKKGEAAGDKFYDHIILRLTVEYNTDVAKGYPATAQTRYVTMVKFQDTDNSKITSFEAGKIYKLDLQELTKDFTTDDEGNPTGPDTPDPEQEGQHILVVKVKSWTWTAVNIKPDVNGGYKK
>NC_015501.1|WP_013760077.1|645715_646618_+|FimB/Mfa2-family-fimbrial-subunit
MAKKVLLLPLTVLLMALLSSCVYEDLSKCPEPRLRFVYNADGSENVVPNYIRDGQLYIYDESGAVCYTQRLTRRDLAEGIQLPVLTFAQYRVIAWGNVSDHSQIAHSDRLAEADITALPDDKGIYRGTDSLYRAELLLDLRNTLQGEYTVPFSSAHIGLDVVIKGYDTFHPGAGAPQVEILSGGTHYTFVEHPAGIPLPDAHKPFVPYMGHSERDDMYRARFDLFRFTDAEAPVLRLTDSQTGKEIRRIALTDYLKSQGISFDKLQEANLPLLITFTGALDITINPFVWGSINIRPDKYK
>NC_015501.1|WP_044211216.1|646831_650473_+|hypothetical-protein
MTRLTTYTIHIISGLLLALLTAGCVADRNVSDCITEGDEVELEFALKVPALETSLRQLTLQQESEVKSVRVLVFNTKDASDNDLAEDQETFAYEAQVTTTNLTPDAEGVTRIVCKLLATEKPMRIVCIANHNVPDGILTVGTAKKTILENNDGMKKPFTQQGWKTDGSQPIPMWGESDKQPVKPTTKFNSCTKLAYGNATQNRNNDGVIHLVRALARVDVGVNFEADPSSEKPVAGGTDFKIMSVRVYRYATSMYVAGTQETAFNFDNGRRNALPHTPADVATAADANPLVFTAAAKDAKSYVRNIYIPEIENKTKTKAQRICLVIGGDYNKSGKQTYYRVDFIRTEEDASGKKTTEQLDILRNYRYRFNITKVAGPGTNSPEEALITEPVNIAYDCLVWDDADIDKIVYDGQYYLAVSKDKFDFGRSEGNEPFTVRTNWPEGYKIVDKDGKEWPKAATDLQGTDKWAYISPTGSQKLVNEDMTSTVNVLANPGAPRTIAPTELFVQAGRIKWPLKINQSNEIAVYIRLYEQVGGKRVPTNLLEIKKGETKIVEVEYTPGANLERRVTDAGSQFLWERTDDGSVSGKAVYKITPDESRIDEETFNLIAAARFIADLDGRAANADLTVMLQVYNAIPYRFGDLHLNMINSTENGYVLDNREQSFYIKANAPYQLIITSIQTSPNDIQSFQDKVVKGWNARSNKLVHESVGHLSGDRISFTPYDYTFGETGITPGDVTIAKITFNIVPTDPQKTFETKQFTILLASSIIQPTANCYIIKRGAKLPILIPVSEQILKAAEWYEQFEDVMEATVKQRANGASGDVNGFDKNVINKYLADEASRLTRLEATDDNWEIDCLWSTIDHTGGGPGLTFKKVQIEGFGKRNYMSVAVDPNSDDIGSAVLVVRRPGNDGEILWSWHIWVVDNYPWEPLQGSKSPLPFMNRNLGARYQKTDKSPIYDPNQAGMYYQFGRKDPFHPYNKASGEGVKLYQNTNLIFDNPAMQKSTISYQKRIKRLPQHNMQTLFEMSDLKRFWRMKDFVRDPSGMGFFDSSFSNSMEWGPWEFRNEAGNTAWQGTTAVTTYMEVSRRICKNKTIKTPFDPSPYGWKVPAVGLESNYADSRGFYPAASGCFPQGDSRKLEWIKDTDKYSAYSVSTRINVRDINPGIQYDYSTRIMNYNMLRGTSTNPSAAIPVRCRVNENELDYKAFTEEGFFQRRR
>NC_015501.1|WP_013760079.1|650747_651404_+|orotate-phosphoribosyltransferase
MTSKVSDQQCTIAQSVAHRLLAIQAVELRPDAPFTWASGWLSPIYCDNRKTLSYPEHRSYIKQAFALQVSDRYPDAEVVAGVATGAISWGALVADELGLPFVYVRSSAKDHGKQNLIEGYLPEGARVVVIEDLISTGGSSMKAVEALQAAGAQVEGLMAVYTHGFAEAEDLFAKAGVEMRTLTDYNEVIRQAVSAGYVSEHDLEMLAQWRENPSQWGR

Crispr_ID: NC_015501_4

• CRISPR_ID: NC_015501_4
• CRISPR_location: 980764-980895
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers
• Cas_protein_info: RT

Consensus repeat of NC_015501_4

Consensus_repeat	Method
AGAATAAAAAATCTCCACGTGGA	CRISPRCasFinder

spacers of NC_015501_4

>4.1|980787|21|NC_015501|CRISPRCasFinder
AATTCTCAAATCTCCACGTGA
>4.2|980831|42|NC_015501|CRISPRCasFinder
GATGAAATGAAACTTCGGAGGAATCGTTTCGTCCCTACGTGG

CRISPR arrays and Neighbor proteins around NC_015501_4

CRISPR arrays

The CRISPR arrays of NC_015501_4

>merge|NC_015501|4|980764-980895|CRISPRCasFinder
GAATTCTCAAATCTCCACGTGGAAATTCTCAAATCTCCACGTGAAGAATAAAAAATCTCCACGTGGAGATGAAATGAAACTTCGGAGGAATCGTTTCGTCCCTACGTGGAGAATAAAAAATATCCACGTGGA

>NC_015501|4|4|980764-980895|CRISPRCasFinder
GAATTCTCAAATCTCCACGTGGA	AATTCTCAAATCTCCACGTGA
AGAATAAAAAATCTCCACGTGGA	GATGAAATGAAACTTCGGAGGAATCGTTTCGTCCCTACGTGG
AGAATAAAAAATATCCACGTGGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015501.1|WP_044211292.1|988906_990490_-|polysaccharide-biosynthesis-protein	unknown	unknown	gnl|CDD|225153
NC_015501.1|WP_100084249.1|981314_983351_-|polysaccharide-biosynthesis-protein	unknown	unknown	gnl|CDD|224011
NC_015501.1|WP_013759989.1|992419_993700_+|group-II-intron-reverse-transcriptase/maturase	RT	pfam00078_RT_CAS-I:CAS-III	gnl|CDD|275209
NC_015501.1|WP_013759745.1|975077_976958_-|IS1634-family-transposase	unknown	unknown	gnl|CDD|227708
NC_015501.1|WP_013760249.1|984227_986732_-|polysaccharide-biosynthesis-tyrosine-autokinase	unknown	unknown	gnl|CDD|349772
NC_015501.1|WP_013760243.1|970473_971463_-|D-alanine--D-alanine-ligase	unknown	unknown	gnl|CDD|234993
NC_015501.1|WP_013760245.1|972601_973255_-|PASTA-domain-containing-protein	unknown	unknown	gnl|CDD|275384
NC_015501.1|WP_013760247.1|978658_979564_+|hypothetical-protein	unknown	unknown	unknown
NC_015501.1|WP_004331356.1|971493_972618_-|RluA-family-pseudouridine-synthase	unknown	unknown	gnl|CDD|223638
NC_015501.1|WP_044211294.1|990682_991390_+|hypothetical-protein	unknown	unknown	unknown
NC_015501.1|WP_013760246.1|978065_978662_+|hypothetical-protein	unknown	unknown	unknown
NC_015501.1|WP_013760250.1|986775_987597_-|polysaccharide-biosynthesis/export-family-protein	unknown	unknown	gnl|CDD|224512
NC_015501.1|WP_013759848.1|973468_973861_+|hypothetical-protein	unknown	unknown	unknown
NC_015501.1|WP_013760251.1|987782_988892_-|polysaccharide-pyruvyl-transferase-family-protein	unknown	unknown	gnl|CDD|377253
NC_015501.1|WP_013760242.1|969298_970477_-|hypothetical-protein	unknown	unknown	unknown
NC_015501.1|WP_081460329.1|993845_995948_-|M3-family-metallopeptidase	unknown	unknown	gnl|CDD|341051
NC_015501.1|WP_004331354.1|980160_980526_-|50S-ribosomal-protein-L19	unknown	unknown	gnl|CDD|235418
NC_015501.1|WP_013760256.1|996075_996309_+|exodeoxyribonuclease-VII-small-subunit	unknown	unknown	gnl|CDD|376855
NC_015501.1|WP_013759847.1|973892_974951_+|transposase	unknown	unknown	gnl|CDD|376574
NC_015501.1|WP_004331338.1|983455_984199_-|hypothetical-protein	unknown	unknown	gnl|CDD|226870

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_015501.1|WP_013759989.1|992419_993700_+|group-II-intron-reverse-transcriptase/maturase	RT	pfam00078_RT_CAS-I:CAS-III	7.9e-53	173.9	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015501.1|WP_044211292.1|988906_990490_-|polysaccharide-biosynthesis-protein	gnl|CDD|225153	COG2244, RfbX, Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only].	3.49849e-15
NC_015501.1|WP_100084249.1|981314_983351_-|polysaccharide-biosynthesis-protein	gnl|CDD|224011	COG1086, COG1086, Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism].	4.00368e-163
NC_015501.1|WP_013759989.1|992419_993700_+|group-II-intron-reverse-transcriptase/maturase	gnl|CDD|275209	TIGR04416, hypothetical_protein, group II intron reverse transcriptase/maturase. Members of this protein family are multifunctional proteins encoded in most examples of bacterial group II introns. These group II introns are mobile selfish genetic elements, often with multiple highly identical copies per genome. Member proteins have an N-terminal reverse transcriptase (RNA-directed DNA polymerase) domain (pfam00078) followed by an RNA-binding maturase domain (pfam08388). Some members of this family may have an additional C-terminal DNA endonuclease domain that this model does not cover. A region of the group II intron ribozyme structure should be detectable nearby on the genome by Rfam model RF00029. [Mobile and extrachromosomal element functions, Other].	1.45781e-175
NC_015501.1|WP_013759745.1|975077_976958_-|IS1634-family-transposase	gnl|CDD|227708	COG5421, COG5421, Transposase [DNA replication, recombination, and repair].	1.03871e-07
NC_015501.1|WP_013760249.1|984227_986732_-|polysaccharide-biosynthesis-tyrosine-autokinase	gnl|CDD|349772	cd05387, BY-kinase, bacterial tyrosine-kinase. Bacterial tyrosine (BY)-kinases catalyze the autophosphorylation on a C-terminal tyrosine cluster and also phosphorylate endogenous protein substrates by using ATP as phosphoryl donor. Besides their capacity to function as tyrosine kinase, most of these proteins are also involved in the production and transport of exopolysaccharides. BY-kinases are involved in a number of physiological processes ranging from stress resistance to pathogenicity.	7.55704e-48
NC_015501.1|WP_013760243.1|970473_971463_-|D-alanine--D-alanine-ligase	gnl|CDD|234993	PRK01966, ddl, D-alanine--D-alanine ligase.	3.2738e-116
NC_015501.1|WP_004331356.1|971493_972618_-|RluA-family-pseudouridine-synthase	gnl|CDD|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	1.07449e-107
NC_015501.1|WP_013760256.1|996075_996309_+|exodeoxyribonuclease-VII-small-subunit	gnl|CDD|376855	pfam02609, Exonuc_VII_S, Exonuclease VII small subunit. This family consist of exonuclease VII, small subunit EC:3.1.11.6 This enzyme catalyzes exonucleolytic cleavage in either 5'->3' or 3'->5' direction to yield 5'-phosphomononucleotides. This exonuclease VII enzyme is composed of one large subunit and 4 small ones.	8.38662e-09
NC_015501.1|WP_013760250.1|986775_987597_-|polysaccharide-biosynthesis/export-family-protein	gnl|CDD|224512	COG1596, Wza, Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis].	7.21642e-19
NC_015501.1|WP_013760245.1|972601_973255_-|PASTA-domain-containing-protein	gnl|CDD|275384	sd00037, PASTA, PASTA domain. PASTA domain is found at the C-termini of several penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular domain consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.	5.93306e-19
NC_015501.1|WP_013760251.1|987782_988892_-|polysaccharide-pyruvyl-transferase-family-protein	gnl|CDD|377253	pfam04230, PS_pyruv_trans, Polysaccharide pyruvyl transferase. Pyruvyl-transferases involved in peptidoglycan-associated polymer biosynthesis. CsaB in Bacillus anthracis is necessary for the non-covalent anchoring of proteins containing an SLH (S-layer homology) domain to peptidoglycan-associated pyruvylated polysaccharides. WcaK and AmsJ are involved in the biosynthesis of colanic acid in Escherichia coli and of amylovoran in Erwinia amylovora.	6.98079e-23
NC_015501.1|WP_081460329.1|993845_995948_-|M3-family-metallopeptidase	gnl|CDD|341051	cd06456, M3A_DCP, Peptidase family M3, dipeptidyl carboxypeptidase (DCP). Peptidase family M3 dipeptidyl carboxypeptidase (DCP; Dcp II; peptidyl dipeptidase; EC 3.4.15.5). This metal-binding M3A family also includes oligopeptidase A (OpdA; EC 3.4.24.70). DCP cleaves dipeptides off the C-termini of various peptides and proteins, the smallest substrate being N-blocked tripeptides and unblocked tetrapeptides. DCP from Escherichia coli is inhibited by the anti-hypertensive drug captopril, an inhibitor of the mammalian angiotensin converting enzyme (ACE, also called peptidyl dipeptidase A). OpdA may play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. It can also cleave N-acetyl-L-Ala. This family also includes Arabidopsis thaliana organellar oligopeptidase OOP (At5g65620), which plays a role in targeting peptide degradation in mitochondria and chloroplasts; it degrades peptide substrates that are between 8 to 23 amino acid residues, and shows a weak preference for hydrophobic residues (F/L) at the P1 position.	0
NC_015501.1|WP_004331354.1|980160_980526_-|50S-ribosomal-protein-L19	gnl|CDD|235418	PRK05338, rplS, 50S ribosomal protein L19; Provisional.	1.07913e-57
NC_015501.1|WP_013759847.1|973892_974951_+|transposase	gnl|CDD|376574	pfam01610, DDE_Tnp_ISL3, Transposase. Transposase proteins are necessary for efficient DNA transposition. Contains transposases for IS204, IS1001, IS1096 and IS1165.	4.51514e-31
NC_015501.1|WP_004331338.1|983455_984199_-|hypothetical-protein	gnl|CDD|226870	COG4464, CapC, Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane].	3.49516e-36

Protein sequences

>NC_015501.1|WP_004331354.1|980160_980526_-|50S-ribosomal-protein-L19
MDFIKLVEEDFQSGKQLPKFAPGDTIVVDYRIKEGNKERIQKFRGTVIRISGHGDQRRFTVRKISDGVGVERIFPFNSPFIEEIHVERHGKVRRAKLYYLRNLRGKAARIRERRTLSASVK
>NC_015501.1|WP_013760247.1|978658_979564_+|hypothetical-protein
MNRILYRILIGAATSLLLCTGVSAQKTSTYKRLPNGRYVSEKPRKAHRAVSQEDEMPVGLALGVSVPDGVTAQCAVRIIPQLTIRAGVGFFPKLQVYKRTFDLGDAAQMQSYRDALGYTPQVYTNAAYSNLNGQLMLDWHPMENGFRVSGGIYLGAPKVHAHGMMIDAKTKESIMKQESSLDPNNMPSITISDDNDASQSVTIQPSSEAALDATATLGRTVRPYIGIGYGQMAPSDKPVSFFIDLGVLLAGKARIASPNVIAGDPNVLVDFDASVQDVVYKAQFLPVLNVGVAIRLGEPIQ
>NC_015501.1|WP_013760246.1|978065_978662_+|hypothetical-protein
MTNKHFYAVLVLAFTLFALQSCDPKTPVRKPVVEATVPSVKVFEIPLDVSSALDVSQKTTLDLRDAQEKVLYEDCLSWDMSDVINSSGFSQAEIKSIRLDKMTIECIKPEGVDLTLFAPMRLYAGQNYKLIAETNAENAHPNLLDLVLHEKDLAQYITADQLPIRISTTRDKISEWPYGDTNVYVKITLSITSTVRAK
>NC_015501.1|WP_013759745.1|975077_976958_-|IS1634-family-transposase
MHANVQTRFNPTIGEKAPYYRLKESYRDVRGNVHSLILLNVGFDPSIDALQAKKIARALTNRFENRHATTLFSERLNGLTEHEQAKADEWWNRMVQEGGIDRFDKREQAARKEAEHYIDLDSAKHTDARNVGAEWLCKQTIDKLELESFLKRQGWSEQAIHTALSALIVRTVYATSEHASYFTMRDNSAATELYSGRPDWLPGRNALYTITDQLFALKEQLEHHLCMMTDHLFNIDNKLMLFDLTNFYFEGSKRNSQKSKFGRSKEKRSDCKLLVLALCINKEGFIRYSSILEGNTADPKSLPDMIESLAQKSPARKEKTLIVMDAGIATEENLTKIKAKGYNYLCVSRTRLKEYTLRENHKCIVVQDSSKREIKLREVHTAPDEDYFLEITSPSKAMTEASMNRQWRSRFEAELIKINEAIKKKGGTKKYERVVERTGRAIERYPSIARYYEINYIRSEEKPLEMQEVAWKIKDLSKVEGGHGGYFLRTNVRTLDERTTWDYYNLIREIECTNRQLKTDLHLRPLFHQTDQRSDAHLFFGLLAYWVVNTIRCGLKAQGENCYWREIVRRMSTQKLVTTEGVNPLGEKVEMRQCSKPSKQATEIYQKLGLREAPFRKIKICRTQSP
>NC_015501.1|WP_013759847.1|973892_974951_+|transposase
MGMSSKKLFRWYKDVLSGYKSPGHQRHLQKTGASRSLGSSAKSPVSSDLKIPILNEKNMGSIICIDEKNINGDCYTIVSNPETNKIVLMVNTLRASQIVYLMRSNISQEALFAVSCVTRDMAPNYDWVARELFPNAYQVADKFHVVKNIIDQVQSVRIRYRQELLRKQRELEEASRKRSKLQPAPKIQQELKEFKKELSNGDTQLQLLQRSKGLLHKLHNEQTASQKLRARLLFRLFPDIKEAYKFSVALRKWYQRPMRNGTSITPSRHLLECKKKALLEIITNHLSSPCEEVKNIAHFMVKHIGEICNYFLGYKTNASAEALNQNLQRFIAINYGTRNSDFFLYRIAVHFS
>NC_015501.1|WP_013759848.1|973468_973861_+|hypothetical-protein
MTKELDWIELFAPQEILRDFNFEKLVEENGIYRIFMVEKDDAAHIPAELKKEVNGDLSNIVLDGYTNYIELQTFPAMGKEVFLYLKRRRWKVKQDQRQEEKSYSNSYSYNEKGMKATKAFGNFLKEIDWV
>NC_015501.1|WP_013760245.1|972601_973255_-|PASTA-domain-containing-protein
MRRPSLLIHIGLMILASVIIVVLALVWMNLFTRHGSSVEIPNIYGLPASEAVQLLDKADLRYEVIDSVYTTEVPKGAVYDLSPKAGSRVKAGRIIFLTLNASSPRNGIIPSLVDVSERQARARLVSLGFENITPSYVAGSFDDLVMGVQLPSGQTLAPGTRIPLATPLILLVSVATSDSIPHGAFGPYDSITGTGGQVLPTDSTKHILEPDEDESWM
>NC_015501.1|WP_004331356.1|971493_972618_-|RluA-family-pseudouridine-synthase
MSPGCNPDRESLPLEEQELEADLIATDEEDQWVAGAHGEELYEHYRVQVDPGQTPLRIDRFLVDRMPHTSRHRIQLAAKAGLIWVDGEPVKSNYKVKPLETITMMLAHPKQDWSITPEDIPLDIVYEDDQLLVVNKPAGMVVHPGHGNYSGTLVHALAYYLRNDPLYDPNDASVGLVHRIDKDTSGLLLVAKRTEAKIRLARQFFLKTTGRRYQALVWGKLDQPQGTIEGNIARDPRDRTRMTVYPPTSEIGKPAVTHYTQLERLGFVTLIACELETGRTHQIRAHMKSIDHPLFGDERYGGDQILWGQRTSSYQQFVNNCLKICPRQALHAETLAFDHPTTGERMHFSAPLPDDMRQLIDKWRRYVAPLELSN
>NC_015501.1|WP_013760243.1|970473_971463_-|D-alanine--D-alanine-ligase
MDKPNIAIICGGYSGEAEVSQRSAQTILKQIDQTLFTPYLVTITRDAWSVTDAEGKAGTIDHALVARFGTAEVTFALAYITIHGTPGENGLLQGYLDMLGIPYTTGGVLCEALTFNKEACNAYLAHHGLRIARSHCLRNHTREFSSEEQELIQSRLRLPLFVKPNTGGSSIATTRIDQWEQLSTAVADAYTAAPDVLIEECIVGTEVTCGCVVLPDDSFALPVTEVVAHDTFFDYDAKYYGKSDEITPARISPEQTQRVQETSLTIAHLLDCYGFVRIDYIIEADGIPTLLEVNTTPGMTEASFIPQQVRAAGLQLSDLITRIIKSKLS
>NC_015501.1|WP_013760242.1|969298_970477_-|hypothetical-protein
MTTHTAPQPYEYDSIRPYLDEEVPAVVAQLANQPELHYVLSALLSEDETTALLQHLKSIQSVDAFKELISYPLVVKLAKQTTFSVSLSGASRLGGDLPTTFVTNHRDIILDSAFLNLVMRERNYLMPRIAIGDNLFGRPWIEAVVKLNDSFVVRRSLPIRQMLLAAQALSAFIDQSIQQDHKSVWIAQREGRAKDNSDQTQPSVLKMIASSQSNDPLTQLMRVNIAPTTISYEYDPCDILKACELLWRKHHPNEQYVKGGEEDLINMKTGLLGYKGRVHFAIGTRLNELITPELEAELRALPKQQLYPHLATIIDTELHSNYRFYPINYIAYDLLHPDKAHPKELYSEADKEKTLRYLEEQIAKAPTDAYSADELRTQLLQMYAQPLLNAQH
>NC_015501.1|WP_100084249.1|981314_983351_-|polysaccharide-biosynthesis-protein
MVTVKTKEFLRKCLGSRYVNYRIIALIDLLLSIIASLSAIFITSYTLLTLTGVYFHETIIEYTGLTHPTLSFLGLSGVVSLIVLLIFPVYKGIIRIRTFSNGFNYLWLSLSKAFVLGLISGILSRGWLFGVLYFALDTFFTLFFLTGFRIVVQFVWRFVNGVPSTISRTPALIFGVNDRSSQLAEKLSNSYQDKGLYVIGYVETEQPAKSMTVGGKPIFYAPDTDSFSALLEKHHVSVLLFAGYDVLHENAPFASICIDRKIRLLVDQEPRRILNVDSRPPIEEIQIEDILGRESIFLNMKPISDALHDKTILVTGATGSIGSEIVRQLARLEPQLIVLFDIAETPMHELRLELQRCCPNGRFAYVMGDIRNPQRLDFVMRKFHPDKVFHAAAYKHVPLMEENPCEAVATNIVGTFNIASKCLEYGVDQMVMLSTDKAVNPSSVMGATKRFCEMIVQSLDLAIKRGEVQTTMTTRFATTRFGNVLNSAGSVIPTFKRQLQRGGPLTVTDPRIERYFMTIPEASQLVLEASMLSHGGEVFVFDMGDLVKIADLAERMIRLAGYEPDKDIKIVYTGLRPGEKLYEETIHDKEKDLPTAHNKIHIVQTREESFERIHRMVLLFRQLAHQGNVDGVVYLLKQAIPEYKSLNSETFASFERGEHIPFDLEEELGKVAAELPHN
>NC_015501.1|WP_004331338.1|983455_984199_-|hypothetical-protein
MWWTRNRTVDIIAAGWLEGMTDIHCHLVPAVDDGSRSLDETRQLIETMHSIGIQRIITTPHIYRRYPHNDSNTLQQEVERLLPDLSDLGVPLTLGAEYMMDEGFEAQLSKPLLTLGSSKFLLVETSFIGAPLDLYRLIQLVISAGAIPMLAHPERYLYMSDGAYSRLRGAGCAFQLNLFSLTGMYGEQVQKRAQQLLERGFYDFVGTDTHRIDFFRKTISSAKTYARYEEPIRALMSNNQTLVATRE
>NC_015501.1|WP_013760249.1|984227_986732_-|polysaccharide-biosynthesis-tyrosine-autokinase
MEYQTASTQQEPIRSSEEVSTFSLRDILMILKANWLFILLSFLVCLALGFLYIKSSSHQYSRSASLLIKSETSINSAIERLAQFTGDKHSYSDDVSNQIIILGTERVVSETVRRLGLDVQYHYDAGLREKDLYKQSPVSIRFVNADPDEKISLRIKSDKEAHNQVILYDIKSSLIGKVQEPIAATLGDTIATPIGKVVVEATPYYSNFPNYEVLKVQKDNFNAVVRNYMKALQVSLQQKDASVIKLTIQAGNPLLAEDFLSTLILVYTELERSDKVKIAESTQRFVDDRLAIISSELGQVDAEIEDFKQSQQIADIQAEAQEYIKGSSEVKTRLVELNNSISIAQFVRGHLKDKNQMESLIPANVGIASPSIEAAIAKYNEFLLKRDQLQANSSSQNPLVQELNTQLAAQRLSIITSIDNLISTLEVERQGILSEQSSYKGRITSVPMQERIVGSIYRQQKIKEELYLFLLNVREQNALSIEAAESNARLIQTPTGPTEPVSPRAPIIMLAAGLLGLLIPMGILYIRGIANNKIRGKADIERYTSIPVLGEIPHYKASKKHIKQVEEQIKDQLVGLSSKERNEIIDQAARMFIVGHHRRSVVSEAFTVVRSNISFLTPNSTQQVKRIMITSAILGSGKTFSSSNLALSLAQAGSRVLLIDCDLRKNTLSKAIGMHRSGLDGLSTYLSDSKVDPQKIICPTTVADSLFFTPSGPIPPNPTELFMSPRFEALLDYADKQFDYIVLDTIPVLNLADTRVISPLADITIMIARENHLPRRLLPELETLYRERLLKGLSIVVNDAGVGASSYGYGYGYGYGYGYGYGYGSESEHDSKSN
>NC_015501.1|WP_013760250.1|986775_987597_-|polysaccharide-biosynthesis/export-family-protein
MKSLVRLNTPFFGVLLVATLCLITTSCASRKDVVYLQDASIGSQSQYSVPVLHIAKGDMLGITVNSKNRELSDPFNLPMVGYYSAFGISAANTQQGYLVDDEGYVTFPTLGRIKAEGLTRNELNNKIATALRDQGLLNDATVTVSLLNAQISVLGEVARPGRFPMVSDQVSILDAIAMAGDLTIQGRRDNVLVIREINGERYIIAHDLRSNNIFESPCYFLRQGDIVYVEPNNAKAQTASINPNNNVGTWLSVVSTATSLTTFVFTIIASQKK
>NC_015501.1|WP_013760251.1|987782_988892_-|polysaccharide-pyruvyl-transferase-family-protein
MTTKRIHILTHPLGANYGGIMQAYALQQALRQLGYDPVTLDIPFDQRSPLRRWAKSRLLTLKQIPYDQSRKAERIIQQHTSRFVQQHITLSPRLRSAKELREYYRQQPAHAYIVGSDQVWRQAFVPMLDDYFFRFIPESDPVRRIAYAASFGVDPIDIAPERTARYSDLLSRFVAISVRELSAVPILKQQFGASAQWVLDPTMLLTREEYIDLFGLRVEPSSGVFAYMLTDTPHKEALAQQIAQSQHTTYQLFSPWRHWTARGESLEECILPPVEAWLEGILNAQYVVTDSFHGVAFSLIFGKPFVAIVNNHGGCSRFDTLIKTFGLESQQEGAYELVSSPERYDVQAIAQKMSQHRTDSMDFIKNALR
>NC_015501.1|WP_044211292.1|988906_990490_-|polysaccharide-biosynthesis-protein
MAQDLHNKTTDERSMQSSRSQRIARNTLFLFVRMAVVTLLSLYISRVLLAALGAEDFGIYQVVGSLVTAFGFINGAMVSATQRFYSYELGRGNLSGVGRIYSVSIVVQLLLVLLVCAIAIPFGLWYVPNKLVAPPERMTVALWIYFISLGTFVVNMMLTPFQSLIVSHERMNLFALLSIVDIALRLGAVLLLKSYAGDQLLLYPILLLAVSGVMALCYVGSTRRLFRQVHFRWVRDRPAYREILSYSGWNLFGNLAAVAQTQGINIVYNYFFGPLLNAAFGIVNSVRSTLLIFANNYQMAANPQIIKSYAAEEYGYLHKLICASAKISYLLMLCVVIPFALDLDLLLRLWLVKPPEYASLLLQLTLIVLLIESLSGALMTGIQATGRVRTYQVLVGGMIIMILPLSMLAFWLGAPPEYSVYINIVVSIACLAVRLVLSYKYHALGVGYYLKRVVLPILPPTIVMLLGAYLYRRWLPYVGSIWGLLVASILLGGLCAVVILTLSLTGEEKRLVKGYLHLSKRRQAPND
>NC_015501.1|WP_044211294.1|990682_991390_+|hypothetical-protein
MMKYIAYMICAASLLGLLLLATSCSKSVPPTPQEPQENTFKAKFMATPNSFSGYGGYGKVHGVLQELSPSGELLHETPLGNSEFTLHFEKYSSEIEPCAYRPNEFFVREGINAKTFKIEAEVISGKGKGCKQTILIMRGGWRFSFKAEPSQFTSKGGSGKVIGTMYITDFDGNVVKESDLGDCNFGLNVVGNPKGITIDDLEKTFTVAAGGPTTFELQACTGYGQPYLIEIKREG
>NC_015501.1|WP_013759989.1|992419_993700_+|group-II-intron-reverse-transcriptase/maturase
MKLIEQILAKNNVREALNRVVSNKGASGIDGMKVEELRDYMNANWTSIKQSILERRYKPAPVRRVEIPKPNGGVRKLGIPTVVDRTLQQSIVQVLTPIFEAEFQENSYGFRPGRSCEQAVQKLLEYLNEGAEWIVDIDLEKFFDNVPQDKLMSYVGRVIHDPDTESLIRKYLKSGVMENGLYEATELGTPQGGNLSPLLSNVMLNELDKEMVRRGLRYVRYADDCVIAVRSEASAKRVMHSVTQWIERVLGLKVNATKTHVCRPSKLKYLGFGFYKSPQTKQWTARPHEDSVAKFVRKLKKLCKRSWSISMTARITMLNRVIRGWINYFAIGAMKGKMVGIDEHLRTMLRKVIWKQWKTPRKRAWGLRKLGICNDLAKLTSCSGDRYEWVVRRTCVVRAISKDVLARRGLVSCLDYYAIRHSLKTN
>NC_015501.1|WP_081460329.1|993845_995948_-|M3-family-metallopeptidase
MLLAIAMMLTACNKQKQQQTDLADNPFVHPSETYMNAPDFTKIKAEHFAPAFDEGMRQHNEEIAAIVDNAEAPTFTNTIEALERAGQVLQRTSAVFFALTSADTNDELRAIEEEYVPKLTAHSDEIMLNDKLFARIKTVYETGLEGLQPDQVRLTKQYYDNYVKAGANLSAEDKEKLKKLNGEEAELTAKFGNMLTDATNVPVFFTDKAQLDGLSDSELQEAADLAKEEGKEGQWAIRLVNTTQQPVMAKLNNRDTRKAILEASINRCNNGDKYDTQEIIKRLATLRAEKAQLLGFKTFADWTLQDALAKNGETARNFLDRLAKLYQPKAAEDAKMLEEFAQKSEGPDFKLEAYDWAYYAEKMRKEQYDIDETQLSEYFVLDNVLHDGVFYAANKLYGLTFEQRTDVSVYNPDVTVYDVKNEQGEVIALYYFDPYARPSKSGGAWMSNFVEQSTLLGNKPVIYNVCNNKKPAAGQPCLMTWDEVTTLFHEFGHALHGMLSTQTYPSISGTNVSRDFVEFPSQFNEHWASEPTVFANYAKHYKTGEQMPAELRDKMIAAGNFNQAYSIGENIAASLIDQCWHALAVGDKVDDVQAFEQEALTKYGMLNAQIPPRYRSPYFRHIWSNDYSAGYYSYLWSEAVDNEVYAWIEAHGGMTRENGQRLADILLSRGNSEDLMVLFEQFTGHKEVDIEPLLRFRGLR
>NC_015501.1|WP_013760256.1|996075_996309_+|exodeoxyribonuclease-VII-small-subunit
MTDASNAQTEQPQQTYQEAITRIQEIVRLLETGDIEVDELTKLIEEATGLIQFCSTRLTSIDKEVSQLLQQLDESSE

Crispr_ID: NC_015501_5

• CRISPR_ID: NC_015501_5
• CRISPR_location: 1151851-1153837
• CRISPR_type: TypeI
• Repeat_type: NA
• Spacer_info: 29 spacers
• Cas_protein_info: cas2,cas1,cas4,cas7,cas8c,cas5,cas3

Consensus repeat of NC_015501_5

Consensus_repeat	Method
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	PILER-CR
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	CRISPRCasFinder
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	CRT

spacers of NC_015501_5

>5.1|1151884|35|NC_015501|PILER-CR,CRISPRCasFinder,CRT
TGTTGGTGAGAGTTACGGTAAGTCAGTATCAGTTA
>5.2|1151952|34|NC_015501|PILER-CR,CRISPRCasFinder,CRT
ATTACTCAAAGAAAACTGAGAGGATAAAGCATCA
>5.3|1152019|35|NC_015501|PILER-CR,CRISPRCasFinder,CRT
ACTAATAGAAGATCTATAAGCTATGCCTAATCTAA
>5.4|1152087|34|NC_015501|PILER-CR,CRISPRCasFinder,CRT
ACTGGCTGGACTTTAGCAAGCAAGTTATCCACAT
>5.5|1152154|35|NC_015501|PILER-CR,CRISPRCasFinder,CRT
CATCACGAAACTCATTAATGATTAACTTAACTAAT
>5.6|1152222|36|NC_015501|PILER-CR,CRISPRCasFinder,CRT
ATTCTGAGGTGCCTTATGATACTGCTAAGCCTATGG
>5.7|1152291|35|NC_015501|PILER-CR,CRISPRCasFinder,CRT
GTTGGTCGTTGTATTGGGTTGTATATACTTGGTAT
>5.8|1152359|33|NC_015501|PILER-CR,CRISPRCasFinder,CRT
TGCAGGTATACGGACTATCCAACAACAACCACA
>5.9|1152425|34|NC_015501|PILER-CR,CRISPRCasFinder,CRT
ACCCATAAATAAAAACTTAGGATCCTTAACCTGA
>5.10|1152492|34|NC_015501|PILER-CR,CRISPRCasFinder,CRT
TCAGGCGTTGCGAGTGCCGTCTCTTGCTCCTCTT
>5.11|1152559|34|NC_015501|PILER-CR,CRISPRCasFinder,CRT
GTGCCGAGGAAGTTTAGCAAGACAACCAGCGTGG
>5.12|1152626|35|NC_015501|PILER-CR,CRISPRCasFinder,CRT
CCTCCTCGTCTATAACTATCGTAATTTGCACGATG
>5.13|1152694|33|NC_015501|PILER-CR,CRISPRCasFinder,CRT
TTGTAGGTGCTTGTGTTGCCACCGCTTACGAAG
>5.14|1152760|34|NC_015501|PILER-CR,CRISPRCasFinder,CRT
TCTATTTGTCTTGCTCATCACTGCTGGTTGTTTT
>5.15|1152827|35|NC_015501|PILER-CR,CRISPRCasFinder,CRT
GCAAAAAAGTACCTCGCAAAGTGGTTGAAACAAGT
>5.16|1152895|35|NC_015501|PILER-CR,CRISPRCasFinder,CRT
GAATGAAAGATTCTCAGAAATTCTTTGCGAAAACG
>5.17|1152963|33|NC_015501|PILER-CR,CRISPRCasFinder,CRT
TTGAGGCTGTTGAGGTCTATTGTATATACCTCG
>5.18|1153029|35|NC_015501|PILER-CR,CRISPRCasFinder,CRT
ATCTTAAGAAGCTTGTGCCTGATATATGGCGTGAA
>5.19|1153097|33|NC_015501|PILER-CR,CRISPRCasFinder,CRT
ACAGGACCAAAAACAGCATCCCAATAAACAGAC
>5.20|1153163|35|NC_015501|PILER-CR,CRISPRCasFinder,CRT
ATGTAATTAACGTACTTTCCACCAACACGGAGTAA
>5.21|1153231|35|NC_015501|PILER-CR,CRISPRCasFinder,CRT
CAAAACTAAGGCCGAAGAGCTTACGAAGATGCACA
>5.22|1153299|35|NC_015501|PILER-CR,CRISPRCasFinder,CRT
ATTATCAGGACGAGGCAAACCTGCACTTTCGAAAA
>5.23|1153367|33|NC_015501|PILER-CR,CRISPRCasFinder,CRT
GGTTATGTGCCTCGCTACGATGAATATAGATAC
>5.24|1153433|35|NC_015501|PILER-CR,CRISPRCasFinder,CRT
GGTCAACATCTGACACATTAAGCACATAAGAGTCA
>5.25|1153501|35|NC_015501|PILER-CR,CRISPRCasFinder,CRT
AGACTTACGGTCTTGTATGTAGCGCGCATTCTCGT
>5.26|1153569|35|NC_015501|PILER-CR,CRISPRCasFinder,CRT
ATTTAAACAAGTGTGGGGGGGGTACACGGCTGTGA
>5.27|1153637|33|NC_015501|PILER-CR,CRISPRCasFinder,CRT
CAGATGGTACAGACGATTGTCGGTGCGATGCTG
>5.28|1153703|35|NC_015501|PILER-CR,CRISPRCasFinder,CRT
AGTGGAAAGCTTTATATTTGCACTACAGCAACATA
>5.29|1153771|34|NC_015501|CRISPRCasFinder,CRT
CCGTCTGAGAGGTCGGTGCGTCTTGTGGTCTCGC

CRISPR arrays and Neighbor proteins around NC_015501_5

CRISPR arrays

The CRISPR arrays of NC_015501_5

>merge|NC_015501|5|1151851-1153837|PILER-CR,CRISPRCasFinder,CRT
GTCGCACCCCGCACGGGGTGCGTGAATTGAAACTGTTGGTGAGAGTTACGGTAAGTCAGTATCAGTTAGTCGCACCCCGCACGGGGTGCGTGAATTGAAACATTACTCAAAGAAAACTGAGAGGATAAAGCATCAGTCGCACCCCGCACGGGGTGCGTGAATTGAAACACTAATAGAAGATCTATAAGCTATGCCTAATCTAAGTCGCACCCCGCACGGGGTGCGTGAATTGAAACACTGGCTGGACTTTAGCAAGCAAGTTATCCACATGTCGCACCCCGCACGGGGTGCGTGAATTGAAACCATCACGAAACTCATTAATGATTAACTTAACTAATGTCGCACCCCGCACGGGGTGCGTGAATTGAAACATTCTGAGGTGCCTTATGATACTGCTAAGCCTATGGGTCGCACCCCGCACGGGGTGCGTGAATTGAAACGTTGGTCGTTGTATTGGGTTGTATATACTTGGTATGTCGCACCCCGCACGGGGTGCGTGAATTGAAACTGCAGGTATACGGACTATCCAACAACAACCACAGTCGCACCCCGCACGGGGTGCGTGAATTGAAACACCCATAAATAAAAACTTAGGATCCTTAACCTGAGTCGCACCCCGCACGGGGTGCGTGAATTGAAACTCAGGCGTTGCGAGTGCCGTCTCTTGCTCCTCTTGTCGCACCCCGCACGGGGTGCGTGAATTGAAACGTGCCGAGGAAGTTTAGCAAGACAACCAGCGTGGGTCGCACCCCGCACGGGGTGCGTGAATTGAAACCCTCCTCGTCTATAACTATCGTAATTTGCACGATGGTCGCACCCCGCACGGGGTGCGTGAATTGAAACTTGTAGGTGCTTGTGTTGCCACCGCTTACGAAGGTCGCACCCCGCACGGGGTGCGTGAATTGAAACTCTATTTGTCTTGCTCATCACTGCTGGTTGTTTTGTCGCACCCCGCACGGGGTGCGTGAATTGAAACGCAAAAAAGTACCTCGCAAAGTGGTTGAAACAAGTGTCGCACCCCGCACGGGGTGCGTGAATTGAAACGAATGAAAGATTCTCAGAAATTCTTTGCGAAAACGGTCGCACCCCGCACGGGGTGCGTGAATTGAAACTTGAGGCTGTTGAGGTCTATTGTATATACCTCGGTCGCACCCCGCACGGGGTGCGTGAATTGAAACATCTTAAGAAGCTTGTGCCTGATATATGGCGTGAAGTCGCACCCCGCACGGGGTGCGTGAATTGAAACACAGGACCAAAAACAGCATCCCAATAAACAGACGTCGCACCCCGCACGGGGTGCGTGAATTGAAACATGTAATTAACGTACTTTCCACCAACACGGAGTAAGTCGCACCCCGCACGGGGTGCGTGAATTGAAACCAAAACTAAGGCCGAAGAGCTTACGAAGATGCACAGTCGCACCCCGCACGGGGTGCGTGAATTGAAACATTATCAGGACGAGGCAAACCTGCACTTTCGAAAAGTCGCACCCCGCACGGGGTGCGTGAATTGAAACGGTTATGTGCCTCGCTACGATGAATATAGATACGTCGCACCCCGCACGGGGTGCGTGAATTGAAACGGTCAACATCTGACACATTAAGCACATAAGAGTCAGTCGCACCCCGCACGGGGTGCGTGAATTGAAACAGACTTACGGTCTTGTATGTAGCGCGCATTCTCGTGTCGCACCCCGCACGGGGTGCGTGAATTGAAACATTTAAACAAGTGTGGGGGGGGTACACGGCTGTGAGTCGCACCCCGCACGGGGTGCGTGAATTGAAACCAGATGGTACAGACGATTGTCGGTGCGATGCTGGTCGCACCCCGCACGGGGTGCGTGAATTGAAACAGTGGAAAGCTTTATATTTGCACTACAGCAACATAGTCGCACCCCGCACGGGGTGCGTGAATTGAAACCCGTCTGAGAGGTCGGTGCGTCTTGTGGTCTCGCGTCGCACCCCGCACGGGGTGCGTGAATTGACGA

>NC_015501|5|1|1151851-1153770|PILER-CR
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	TGTTGGTGAGAGTTACGGTAAGTCAGTATCAGTTA
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	ATTACTCAAAGAAAACTGAGAGGATAAAGCATCA
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	ACTAATAGAAGATCTATAAGCTATGCCTAATCTAA
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	ACTGGCTGGACTTTAGCAAGCAAGTTATCCACAT
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	CATCACGAAACTCATTAATGATTAACTTAACTAAT
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	ATTCTGAGGTGCCTTATGATACTGCTAAGCCTATGG
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	GTTGGTCGTTGTATTGGGTTGTATATACTTGGTAT
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	TGCAGGTATACGGACTATCCAACAACAACCACA
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	ACCCATAAATAAAAACTTAGGATCCTTAACCTGA
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	TCAGGCGTTGCGAGTGCCGTCTCTTGCTCCTCTT
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	GTGCCGAGGAAGTTTAGCAAGACAACCAGCGTGG
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	CCTCCTCGTCTATAACTATCGTAATTTGCACGATG
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	TTGTAGGTGCTTGTGTTGCCACCGCTTACGAAG
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	TCTATTTGTCTTGCTCATCACTGCTGGTTGTTTT
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	GCAAAAAAGTACCTCGCAAAGTGGTTGAAACAAGT
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	GAATGAAAGATTCTCAGAAATTCTTTGCGAAAACG
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	TTGAGGCTGTTGAGGTCTATTGTATATACCTCG
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	ATCTTAAGAAGCTTGTGCCTGATATATGGCGTGAA
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	ACAGGACCAAAAACAGCATCCCAATAAACAGAC
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	ATGTAATTAACGTACTTTCCACCAACACGGAGTAA
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	CAAAACTAAGGCCGAAGAGCTTACGAAGATGCACA
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	ATTATCAGGACGAGGCAAACCTGCACTTTCGAAAA
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	GGTTATGTGCCTCGCTACGATGAATATAGATAC
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	GGTCAACATCTGACACATTAAGCACATAAGAGTCA
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	AGACTTACGGTCTTGTATGTAGCGCGCATTCTCGT
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	ATTTAAACAAGTGTGGGGGGGGTACACGGCTGTGA
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	CAGATGGTACAGACGATTGTCGGTGCGATGCTG
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	AGTGGAAAGCTTTATATTTGCACTACAGCAACATA
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC

>NC_015501|5|5|1151851-1153837|CRISPRCasFinder
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	TGTTGGTGAGAGTTACGGTAAGTCAGTATCAGTTA
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	ATTACTCAAAGAAAACTGAGAGGATAAAGCATCA
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	ACTAATAGAAGATCTATAAGCTATGCCTAATCTAA
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	ACTGGCTGGACTTTAGCAAGCAAGTTATCCACAT
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	CATCACGAAACTCATTAATGATTAACTTAACTAAT
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	ATTCTGAGGTGCCTTATGATACTGCTAAGCCTATGG
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	GTTGGTCGTTGTATTGGGTTGTATATACTTGGTAT
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	TGCAGGTATACGGACTATCCAACAACAACCACA
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	ACCCATAAATAAAAACTTAGGATCCTTAACCTGA
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	TCAGGCGTTGCGAGTGCCGTCTCTTGCTCCTCTT
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	GTGCCGAGGAAGTTTAGCAAGACAACCAGCGTGG
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	CCTCCTCGTCTATAACTATCGTAATTTGCACGATG
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	TTGTAGGTGCTTGTGTTGCCACCGCTTACGAAG
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	TCTATTTGTCTTGCTCATCACTGCTGGTTGTTTT
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	GCAAAAAAGTACCTCGCAAAGTGGTTGAAACAAGT
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	GAATGAAAGATTCTCAGAAATTCTTTGCGAAAACG
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	TTGAGGCTGTTGAGGTCTATTGTATATACCTCG
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	ATCTTAAGAAGCTTGTGCCTGATATATGGCGTGAA
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	ACAGGACCAAAAACAGCATCCCAATAAACAGAC
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	ATGTAATTAACGTACTTTCCACCAACACGGAGTAA
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	CAAAACTAAGGCCGAAGAGCTTACGAAGATGCACA
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	ATTATCAGGACGAGGCAAACCTGCACTTTCGAAAA
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	GGTTATGTGCCTCGCTACGATGAATATAGATAC
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	GGTCAACATCTGACACATTAAGCACATAAGAGTCA
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	AGACTTACGGTCTTGTATGTAGCGCGCATTCTCGT
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	ATTTAAACAAGTGTGGGGGGGGTACACGGCTGTGA
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	CAGATGGTACAGACGATTGTCGGTGCGATGCTG
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	AGTGGAAAGCTTTATATTTGCACTACAGCAACATA
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	CCGTCTGAGAGGTCGGTGCGTCTTGTGGTCTCGC
GTCGCACCCCGCACGGGGTGCGTGAATTGACGA

>NC_015501|5|1|1151851-1153837|CRT
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	TGTTGGTGAGAGTTACGGTAAGTCAGTATCAGTTA
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	ATTACTCAAAGAAAACTGAGAGGATAAAGCATCA
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	ACTAATAGAAGATCTATAAGCTATGCCTAATCTAA
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	ACTGGCTGGACTTTAGCAAGCAAGTTATCCACAT
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	CATCACGAAACTCATTAATGATTAACTTAACTAAT
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	ATTCTGAGGTGCCTTATGATACTGCTAAGCCTATGG
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	GTTGGTCGTTGTATTGGGTTGTATATACTTGGTAT
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	TGCAGGTATACGGACTATCCAACAACAACCACA
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	ACCCATAAATAAAAACTTAGGATCCTTAACCTGA
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	TCAGGCGTTGCGAGTGCCGTCTCTTGCTCCTCTT
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	GTGCCGAGGAAGTTTAGCAAGACAACCAGCGTGG
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	CCTCCTCGTCTATAACTATCGTAATTTGCACGATG
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	TTGTAGGTGCTTGTGTTGCCACCGCTTACGAAG
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	TCTATTTGTCTTGCTCATCACTGCTGGTTGTTTT
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	GCAAAAAAGTACCTCGCAAAGTGGTTGAAACAAGT
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	GAATGAAAGATTCTCAGAAATTCTTTGCGAAAACG
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	TTGAGGCTGTTGAGGTCTATTGTATATACCTCG
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	ATCTTAAGAAGCTTGTGCCTGATATATGGCGTGAA
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	ACAGGACCAAAAACAGCATCCCAATAAACAGAC
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	ATGTAATTAACGTACTTTCCACCAACACGGAGTAA
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	CAAAACTAAGGCCGAAGAGCTTACGAAGATGCACA
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	ATTATCAGGACGAGGCAAACCTGCACTTTCGAAAA
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	GGTTATGTGCCTCGCTACGATGAATATAGATAC
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	GGTCAACATCTGACACATTAAGCACATAAGAGTCA
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	AGACTTACGGTCTTGTATGTAGCGCGCATTCTCGT
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	ATTTAAACAAGTGTGGGGGGGGTACACGGCTGTGA
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	CAGATGGTACAGACGATTGTCGGTGCGATGCTG
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	AGTGGAAAGCTTTATATTTGCACTACAGCAACATA
GTCGCACCCCGCACGGGGTGCGTGAATTGAAAC	CCGTCTGAGAGGTCGGTGCGTCTTGTGGTCTCGC
GTCGCACCCCGCACGGGGTGCGTGAATTGACGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015501.1|WP_013760354.1|1159413_1161906_+|YfhO-family-protein	unknown	unknown	gnl|CDD|370572
NC_015501.1|WP_013760349.1|1149656_1150334_+|CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	gnl|CDD|273040
NC_015501.1|WP_013760342.1|1141274_1141730_+|NfeD-family-protein	unknown	unknown	gnl|CDD|224501
NC_015501.1|WP_013760348.1|1148709_1149579_+|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7	cd09689_cas7_CAS-I-C	gnl|CDD|377458
NC_015501.1|WP_013760344.1|1142820_1143696_+|Fic-family-protein	unknown	unknown	gnl|CDD|225095
NC_015501.1|WP_013760347.1|1146850_1148698_+|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	cas8c	cd09757_cas8c_CAS-I-C	gnl|CDD|378245
NC_015501.1|WP_013760355.1|1163938_1165054_-|AMP-binding-protein	unknown	unknown	gnl|CDD|341285
NC_015501.1|WP_013760353.1|1158419_1159385_+|glycosyltransferase	unknown	unknown	gnl|CDD|133016
NC_015501.1|WP_013760350.1|1150330_1151362_+|type-I-C-CRISPR-associated-endonuclease-Cas1	cas1	cd09721_cas1_CAS-I-C	gnl|CDD|188360
NC_015501.1|WP_174258535.1|1156911_1158393_+|cysteine--tRNA-ligase	unknown	unknown	gnl|CDD|234705
NC_015501.1|WP_007364789.1|1151361_1151652_+|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|187856
NC_015501.1|WP_013760358.1|1167058_1168786_-|2-succinyl-5-enolpyruvyl-6-hydroxy-3--cyclohexene-1-carboxylic-acid-synthase	unknown	unknown	gnl|CDD|272941
NC_015501.1|WP_013760351.1|1154151_1155465_-|oligosaccharide-flippase-family-protein	unknown	unknown	gnl|CDD|240533
NC_015501.1|WP_044211331.1|1168801_1169941_-|isochorismate-synthase	unknown	unknown	gnl|CDD|273127
NC_015501.1|WP_013760357.1|1166231_1167062_-|1,4-dihydroxy-2-naphthoyl-CoA-synthase	unknown	unknown	gnl|CDD|180958
NC_015501.1|WP_013760356.1|1165127_1166225_-|o-succinylbenzoate-synthase	unknown	unknown	gnl|CDD|239436
NC_015501.1|WP_004330414.1|1161930_1163619_+|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|276809
NC_015501.1|WP_013760346.1|1146137_1146854_+|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09752_cas5_CAS-I-C	gnl|CDD|187534
NC_015501.1|WP_013760343.1|1141751_1142768_+|SPFH/Band-7/PHB-domain-protein	unknown	unknown	gnl|CDD|223407
NC_015501.1|WP_013760345.1|1143829_1146133_+|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl|CDD|224124

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_015501.1|WP_013760349.1|1149656_1150334_+|CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	3.6e-32	106.7	0.5
NC_015501.1|WP_013760348.1|1148709_1149579_+|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7	cd09689_cas7_CAS-I-C	2.5e-112	369.4	0.0
NC_015501.1|WP_013760347.1|1146850_1148698_+|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	cas8c	cd09757_cas8c_CAS-I-C	3.1e-138	456.4	0.0
NC_015501.1|WP_013760346.1|1146137_1146854_+|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09752_cas5_CAS-I-C	8.5e-75	245.7	0.2
NC_015501.1|WP_013760350.1|1150330_1151362_+|type-I-C-CRISPR-associated-endonuclease-Cas1	cas1	cd09721_cas1_CAS-I-C	1.6e-132	436.4	0.0
NC_015501.1|WP_013760345.1|1143829_1146133_+|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	2.5e-62	205.9	0.0
NC_015501.1|WP_007364789.1|1151361_1151652_+|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	1.9e-27	90.0	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015501.1|WP_013760354.1|1159413_1161906_+|YfhO-family-protein	gnl|CDD|370572	pfam09586, YfhO, Bacterial membrane protein YfhO. This protein is a conserved membrane protein. The yfhO gene is transcribed in Difco sporulation medium and the transcription is affected by the YvrGHb two-component system. Some members of this family have been annotated as glycosyl transferases of the PMT family.	7.83271e-07
NC_015501.1|WP_013760349.1|1149656_1150334_+|CRISPR-associated-protein-Cas4	gnl|CDD|273040	TIGR00372, conserved_hypothetical_protein, CRISPR-associated protein Cas4. This model represents a family of proteins associated with CRISPR repeats in a wide set of prokaryotic genomes. This scope of this model has been broadened since it was first built to describe an archaeal subset only. The function of the protein is undefined. Distantly related proteins, excluded from this model, include ORFs from Mycobacteriophage D29 and Sulfolobus islandicus filamentous virus and a region of the Schizosaccharomyces pombe DNA replication helicase Dna2p.	9.35111e-30
NC_015501.1|WP_013760342.1|1141274_1141730_+|NfeD-family-protein	gnl|CDD|224501	COG1585, COG1585, Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion].	2.09518e-25
NC_015501.1|WP_013760348.1|1148709_1149579_+|type-I-C-CRISPR-associated-protein-Cas7/Csd2	gnl|CDD|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	6.15916e-141
NC_015501.1|WP_013760344.1|1142820_1143696_+|Fic-family-protein	gnl|CDD|225095	COG2184, Fic, Protein involved in cell division [Cell division and chromosome partitioning].	5.45374e-48
NC_015501.1|WP_013760347.1|1146850_1148698_+|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	gnl|CDD|378245	pfam09709, Cas_Csd1, CRISPR-associated protein (Cas_Csd1). CRISPR loci appear to be mobile elements with a wide host range. This entry represents proteins that tend to be found near CRISPR repeats. The species range, so far, is exclusively bacterial and mesophilic, although CRISPR loci are particularly common among the archaea and thermophilic bacteria. Clusters of short DNA repeats with nonhomologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins.	0
NC_015501.1|WP_013760355.1|1163938_1165054_-|AMP-binding-protein	gnl|CDD|341285	cd17630, OSB_MenE-like, O-succinylbenzoic acid-CoA ligase. This family contains O-succinylbenzoyl-CoA (OSB-CoA) synthetase (also known as O-succinylbenzoic acid CoA ligase) that belongs to the ANL superfamily and catalyzes the ligation of CoA to o-succinylbenzoate (OSB). It includes MenE in the bacterial menaquinone biosynthesis pathway which is a promising target for the development of novel antibacterial agents. MenE catalyzes CoA ligation via an acyl-adenylate intermediate; tight-binding inhibitors of MenE based on stable acyl-sulfonyladenosine analogs of this intermediate provide a pathway toward the development of optimized MenE inhibitors.	6.10097e-63
NC_015501.1|WP_013760353.1|1158419_1159385_+|glycosyltransferase	gnl|CDD|133016	cd02525, Succinoglycan_BP_ExoA, ExoA is involved in the biosynthesis of succinoglycan. Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.	7.37776e-54
NC_015501.1|WP_013760350.1|1150330_1151362_+|type-I-C-CRISPR-associated-endonuclease-Cas1	gnl|CDD|188360	TIGR03640, cas1_DVULG, CRISPR-associated endonuclease Cas1, subtype I-C/DVULG. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the DVULG subtype of CRISPR/Cas system.	1.48494e-156
NC_015501.1|WP_174258535.1|1156911_1158393_+|cysteine--tRNA-ligase	gnl|CDD|234705	PRK00260, cysS, cysteinyl-tRNA synthetase; Validated.	0
NC_015501.1|WP_007364789.1|1151361_1151652_+|CRISPR-associated-endonuclease-Cas2	gnl|CDD|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	2.48304e-30
NC_015501.1|WP_013760358.1|1167058_1168786_-|2-succinyl-5-enolpyruvyl-6-hydroxy-3--cyclohexene-1-carboxylic-acid-synthase	gnl|CDD|272941	TIGR00173, menD, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase. MenD was thought until recently to act as SHCHC synthase, but has recently been shown to act instead as SEPHCHC synthase. Conversion of SEPHCHC into SHCHC and pyruvate may occur spontaneously but is catalyzed efficiently, at least in some organisms, by MenH (see TIGR03695). 2-oxoglutarate decarboxylase/SHCHC synthase (menD) is a thiamine pyrophosphate enzyme involved in menaquinone biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone].	7.51124e-127
NC_015501.1|WP_013760351.1|1154151_1155465_-|oligosaccharide-flippase-family-protein	gnl|CDD|240533	cd13128, MATE_Wzx_like, Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	1.8867e-18
NC_015501.1|WP_044211331.1|1168801_1169941_-|isochorismate-synthase	gnl|CDD|273127	TIGR00543, Salicylate_biosynthesis_isochorismate_synthase, isochorismate synthases. This enzyme interconverts chorismate and isochorismate. In E. coli, different loci encode isochorismate synthases for the pathways of menaquinone biosynthesis and enterobactin biosynthesis (via salicilate) and fail to complement each other. Among isochorismate synthases, the N-terminal domain is poorly conserved. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone].	3.21452e-62
NC_015501.1|WP_013760357.1|1166231_1167062_-|1,4-dihydroxy-2-naphthoyl-CoA-synthase	gnl|CDD|180958	PRK07396, PRK07396, dihydroxynaphthoic acid synthetase; Validated.	0
NC_015501.1|WP_013760356.1|1165127_1166225_-|o-succinylbenzoate-synthase	gnl|CDD|239436	cd03320, OSBS, o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway. Menaquinone is an essential cofactor for anaerobic growth in eubacteria and some archaea. OSBS belongs to the enolase superfamily of enzymes, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion.	4.63201e-66
NC_015501.1|WP_004330414.1|1161930_1163619_+|tetratricopeptide-repeat-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	1.16533e-10
NC_015501.1|WP_013760346.1|1146137_1146854_+|type-I-C-CRISPR-associated-protein-Cas5	gnl|CDD|187534	cd09752, Cas5_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex; in subtype I-C this protein might be the endoribonuclease that generates crRNAs; also known as DevS family.	2.42749e-82
NC_015501.1|WP_013760343.1|1141751_1142768_+|SPFH/Band-7/PHB-domain-protein	gnl|CDD|223407	COG0330, HflC, Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones].	2.62468e-60
NC_015501.1|WP_013760345.1|1143829_1146133_+|CRISPR-associated-helicase/endonuclease-Cas3	gnl|CDD|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	2.09864e-53

Protein sequences

>NC_015501.1|WP_007364789.1|1151361_1151652_+|CRISPR-associated-endonuclease-Cas2
MYLLVTYDVNTASPDGAKRLRQVAKICQNYGQRVQNSVFECLVSPAQRVELEAALTDTINLSSDSLRIYHLGTNYQSKITTIGKTKGVDPEGVLLI
>NC_015501.1|WP_013760350.1|1150330_1151362_+|type-I-C-CRISPR-associated-endonuclease-Cas1
MRKLLNTLYILTPNVYLLKDGTNVVARIDGEETFRIPIHNLEGIITFSYMGASPGLMQLCVQEGVKLTFLTPTGRYIGSLEGPTRGNVLLRRTQFRIADDEPAAAHFAALFISAKIANQRSVLGRYLRDYHPTESVEVSFQEALSQLKSLQKSLVYKRDRMTVMGVEGLAAQQYFALFHHLIRRPEFTFEGRSRRPPRDETNALLSFFYTILAHEVTAALETVGLDPYVGFLHTDRPGRASLALDLMEELRAYLVDRFVLTVINKRQVAPSDFIAQGENGYILRDEPRKELLAAWQQRKREEIMHPFLQERIPIGLLPYAQALLLARCLRGDLDDYPVFLIQS
>NC_015501.1|WP_013760349.1|1149656_1150334_+|CRISPR-associated-protein-Cas4
MRHYSDEELLTISEIQHYCFCPRQWQLITLEQLWHDNHLTALGQILHKRVDQPELSARVGDTITMRRVPLVSYSLGLYGLSDAVELTPLRDHSLRPFRHPKYPGAWQATPVEYKRGKPKTHLADKLQLCAQVIALEEMYQVTIPYGALYYGETRHRLQVEMDDTLRAACYEVARKMHEAFAQRTPIPAHYTRQCRSCSLIDECMPRIASHRSAKSYLKHHDILTL
>NC_015501.1|WP_013760348.1|1148709_1149579_+|type-I-C-CRISPR-associated-protein-Cas7/Csd2
MLQNRYDFILLFDVKDGNPNGDPDSDNLPRVDPETGEGLVTDVCIKRKVRNYIQMATDQGIFVRENSVLNDSINAAVEEATGKDAKTKNATDRDKARALMCQKYYDIRAFGAVLSTGNNAGQVRGPIQLTFARSIDPIFPHEHTITRMAATDTKEQKANEEADDKGGNRTMGRKATVPYGLYKMYGFVTPHFAEDTGFTEDDLQLFWEALKNMFDLDHSAARGLMSLQKLIVFKHDSPLGNAPAHKLFERVTIARREGLTSPARDFSDYTVQIDRDGLQGVQVDDIELV
>NC_015501.1|WP_013760347.1|1146850_1148698_+|type-I-C-CRISPR-associated-protein-Cas8c/Csd1
MILQALYNYYEAMRKAHRIATPGLEVKPIRWVIVIREDGSFVRLKNLKDPSDKKSKGQDYLVPAGLKRSGKCPPAQPFWDNRKYILGYEESAEGVSPCTDRLEDFKRLMAEIAELYPDNASFQAVCRFYEHYLGDEMPLPEDAHTERILASDWMTFQLQGDTELLATQDDAHDYTAQAYNTEENLGTCLITGEKKSLASFHARIVAPGSQAGATIASFNDPAYLSYGKKQGENAPISKYASFAHTTALNDLLRNEQTRYTLGDISYVFWNSNLDDPSINETFRTVIFEGVKDDDAQEPSDTDDEQPKRKGKSKKKAPNPTRETYKVLEQFKAIRGNRGQGQHWEDERQFYVLGLTAGGRITIKYWQQGTVSEIFDRVYQHLVDMNIIRRDGNVDEENPPLRSLYGIVKSVSSPSKSSTFAMNLVQSIVESVLNGTPYPMTLQQACINRITKERAVSELRAAILKGCINRKARIYKHLKELDMALDKQNDNIAYLAGRLFAVLEQIQQASLGKGVNATIRDRFYTSASTRPNMVMGRLIALSNHHLSKLRKEKPGLAVNLEKLLGEIFALIPAEVPTFPATFSLDEQSLFAVGYYHQKVDTYKKEDTNNSTEETEQ
>NC_015501.1|WP_013760346.1|1146137_1146854_+|type-I-C-CRISPR-associated-protein-Cas5
MEEYIDKEYCLRVRGPFACFTRPEMKVERVSYDVITPSAARAIFQAIYWKPAIRWEITKIEVLAPIKRFTIKRNEVASIMSKGSTGINISEDRRQRASYILRDVDYRIYAKMVYIPVRNRSASCQKHYNEEYSEAERKAENPRKYQEIFERRAKAGQCFTMPYLGCREFTCSFEYVDLEHGETSLEPKPIPESRDLSIMLYDMDFERDRKNPPAMFYHAQMTEGVILVPPMDSNEILR
>NC_015501.1|WP_013760345.1|1143829_1146133_+|CRISPR-associated-helicase/endonuclease-Cas3
MSNTKQIAHVRALEDGSYETQPLLDHLHGVAELAQSYAERITDDPELGEIGYLLGLLHDLGKYQEGFQRYIRQQSGLDPTLNGWRTPHSPAGARYAYNLKQVGGNQQLLKILSLCIGAHHRGLYDDSEWRGQVVDSSDTKRAVANLVKGLRPEASQLEELLHKASLDKATKAWNKIEEDDYQLLVRMLFSCLVDADFLDTERFMTPDKSLVRQSAKASLEQMRAQLEEYVSHFNREGRINEARAAFLDQCRNHGRTAQRKIYSLTLPTGAGKTVSSMMWALEHAIAQGCERIIYVIPYTSIITQTAQTFRDIFGADQVLEHHSDVDAKERPDEAMEYTKLMTENWDVPLVVTTNVQFFESLYAHRVSRCRKLHNICNSVVVFDEVQMFPPRLLNPILRVVESLHFAFRVEPLFCTATLPVFDKDILSDSKRIGHEFFFLEEPIQEVVPYDAERFAPFDKVRYHWDLLKLSTEELAERLAQHESFLCIVNSRKDAARLYTALQAQDKSGEGLIHLSRRMCSAHIQERIEEIRRRLKAGEPVRVVSTQLVEAGVDLDFPVVYRAMAGLDSVMQAAGRCNREGRMAEPGEVYIFRLDETVSLGEMSWAQGALEDLLDRLAEQGAPQREEIERYYKAFYNDVDCFDNKRDKEVSKLLWNVNDDRCEGLRFDYETASENFRYIENQDIPIVIPYTDEGKAIIKKLQNNLPLTRQEYRQMNRLTVGLKRKDCLTLEGSVSVSDSGIAYLTDDKLYSTETGIQIIDRTLIFTTA
>NC_015501.1|WP_013760344.1|1142820_1143696_+|Fic-family-protein
MSKISIRFFNDREVRAVWDETESKWWFSVLDIIGVLNDQDDYNKNRNYWKYLKTKLKRKESEVVSATNQLKLLAPDGKKRLTDTLDDKGVVALAQSFPNDRAMRFVKWFVGGEETIDGRSRSKAYALFESNLLDSIEVGTVQGLQQIHAYLFGGLYDFAGQIRQVNIAKGGFQFAMAQYLPDTLTSIEQMPEQTWEQIIDKYVEMNIAHPFREGNGRATRIWLDLMLKKQLGLCVDWSQVDKYTYLEAMRASVADATSLKCLLHAALTDKVNDRETFMKGIDYSYYYEQED
>NC_015501.1|WP_013760343.1|1141751_1142768_+|SPFH/Band-7/PHB-domain-protein
MEASLIVLGVLVLLVIYIIAKGLVIVQQSETMIIERLGRYLKTLPSGINLIIPFIDKPRPMVWRITASSSKGGTLVRFINTDRIDLRENVYDFARQSVITRDNVVTEINAVLYFQIVEPLKAVYEISNLPVAIEMLTQTSLRNVIGEMDLDETLTSRDTINNKLRDILDEATNKWGVKVNRVELQDINPPRDIRDAMEKQMRAERDKRAQVLTAEGQKEAMIRESEGRMTESVNHAEGEKKAQILAAEADARATILRAEAEAEAIERITTAVASTGSNPTQYLIAMRYLDTLEKIGRNSSDKTLFLPYEATGILSALGGIKEVSASEVGNLLTKVGKH
>NC_015501.1|WP_013760342.1|1141274_1141730_+|NfeD-family-protein
MFNSPIYFWLIAGLLLLLVELLTPGFVVACFGIGALLAILPAALGASITWQVITFCIGSILALLLLRPMVCRLSRNKETARTGIEALYGRTARVTECIDASRETGRVAVDGDNWRARTVAPDMVIPRGEMVRIVSNDSIVMIVEPITETAE
>NC_015501.1|WP_013760351.1|1154151_1155465_-|oligosaccharide-flippase-family-protein
MSLSLPYQMNRPPLPAPKRLLQRLSSMVRGNRLVLENFLSLGLINVLNSSFHLIIYPILIHRVGAEAYGAYVYAFSIITYFTTLVTYGLDMIGTRYLAHYDKERDLAGKSHITSLIISSRLYLLLLSFLLFLPIVLWVGALAPYRTLLWASFLSVVGCVFMPNWYFIGIQRTRIYLYIQIATKVLLAVAIILWVLTPHHMARYVLLASVSNILAAGIAFGYILWREKLSLHLVALRKCFALLREATPLFLSYLVMTVKSAGLNLVIGSLFGMTSLTGYDFSMKIVSVVMYITKQLNVALFPSVSTSYTTERIRKILRGELLMGIACMAALMLAAKPIIWIMGNGPIEDLILPVFLLMTALIPIWLISGFFIELVLTANGRNREVFVNQLLSLAVIALGAWVAVLLQVELTAFVVIVILSGLIEIAFLYATGRCRALI
>NC_015501.1|WP_174258535.1|1156911_1158393_+|cysteine--tRNA-ligase
MMSQLYIYNTLERAKVPFEPIAPPHVGLYVCGPTVYGDPHLGHARSAITFDILFRYLKHLGYKVRYVRNVTDVGHLEHDADDGEDKIAKKAKLEQLEPMEVAYYYLTRYHDSLRLLNVLPPSIEPLASGHIIEQIALVQQILDAGYAYVSQGSVYFDVLKYHADHPYGILSGRNVEDMISNTRELDGQDEKHNPLDFALWKKAQPNHIMRWPSPWSEGFPGWHCECTAMGRKYLGAHFDIHGGGLDLTFPHHECEIAQAVASQGEPMVKYWMHNNMITVDGKKMAKSAGNFITLEEFFTGDHPALEQAYAPMTIRFFVLSAHYRGTVDFSNSALQAAEKGYQRLMDADAKLQSLKPSATSTIEKIDLAERCKEAMDDDINTPMVIAALFDAARLINSIHDGHEQITSEQLEELRRAYDLYLHDILGMQSATETADLSGSQQEAFAGAMDLLLEIRAKAKASKDWETSDLIRDKLTALGFEIQDTKSGAEWKVL
>NC_015501.1|WP_013760353.1|1158419_1159385_+|glycosyltransferase
MLSLIIPVYNRPDEVEELLHSLAQQQTPPSYEVVIVEDGSTEPCAAVVDRYRDLMSIQYEVVPNGGPSRARNIGARHATGDWIIILDSDVVLPPDYLYNVSQAIAADGCDAWGGPDAAPSLQDGSFGMWQRAINYAMTSPLTTGGIRGGRKRLTKRFYPRTFNLGCRRALFESLGGFDETMRYGEDIDFSMRLYEAGSRVVLLPEAVLYHKRRVDLRKFYRQVWHSGTARVELSRRHPGSMRLTYLLPSLFVVTTLVVTLLALWCPWFWLYHLLFIVSIFADALYRTHSMAVAWRAVVASFVQLSGYGIGYLSQRVKRCKA
>NC_015501.1|WP_013760354.1|1159413_1161906_+|YfhO-family-protein
MKQIPWQRILLIFGFFIIVALGYFTPAHFEGRTLFQADVAGVSGNGSDVQASDETSYWTNSLFGGMPMYQISPSYPSTKPLQYLQDVLTLRKPLSILGTYPWLIFALLVGFYIFMRSLKVDPLPSVLGAVMWALSSYFIILIQAGHIWKLTALCFVPPTIAGLIWCYRGERLWGGALFAFFMALQLLANHVQMTYYFALLMAVLVMTFLVQAIRERQVVDFLKSTGVLILAGLLAIAVNGTNLYHTYQYAQETMRGGSELTIALPHAPEQTGAEVNSKGLSKEYITQWSYGIGETWTLLVPNTKGGATESLAQGHAKQLAKAPYEYQQMLGQMNAYWGDQPFTSGPVYVGAFVCILFIIGCVIVKGPIKWGLLVATILSILLAWGKNFMPLTDLFIDWMPMYDKFRAVSSILVIAELTIPTLAVLALVQLIKEPRLLRSKRVWIAGGVPVLLLLLFALLPDLFFGFLSQQEKGMFAELATQDPRYLMLQDQLETMRMGIFRADVWRSLLFIVLSVVPLWLFAKGYLKAPWLCCILVGLTLVDLWQVDKRYLSDDDFISSRLVQQQAAPMTEADRAILQDKSLGYRVFNQTVNSFNDATTSRWHHSVGGYHAAKLQRYQDLITYQLSTGNMQVYDMLNTKYFIVPNPETKAPMAVTNPDAFGAAWFVDSLRWVANANEEMEALSTADLRHVGIVDRRFGEELPQPLMLPDSTAQRSITVSKYTPRQVVYDVSAEAPGVAILSDIYYPHGWHATIDGQEIPIARANYVLRAVSLPAGNYQLALTFAPRSITVTESIAFTALALILLALIGSIVWRIRPWGKGKKASTDSQTN
>NC_015501.1|WP_004330414.1|1161930_1163619_+|tetratricopeptide-repeat-protein
MTYRNLLKITTALLLAVLVSSCACRLKPLNGSAAQVDPNPLTLVGTQIPGQVRLTLPAKWCHKRAIVNITPQLRYAGTSVTGQTVTIQGENVRDNYQTISYERGGSVIVPFAFEYKPGMEQSDLYLTFTATIKGKKVNLPAIKVARGTIMTAGLASISDVTPALARDAFQRVIKEQYTADLKFLINRAEVRAAELNKREVKDWQDVVDNAYQVPNQEVDIEIQAYASPDGAQDFNERLSAQRERNTSSVVARQLGKKKIEVNAHYTAEDWDGFQKLLEASNIQDKELVLRVLSMYPDPEDREREIRNLSHVFTQLADEILPELRRSRLNANVRIIGKSDDELKMFMAQRPGRLTIEEILYTATLYDNAKDQMNAYQQATQLYPKDYRAYNNIGTLYLAQGNYEQAANYFAKAQKIQPNAASNMNEALLALNRGDLAEAQRLMGSAVEVPEAGQGIGLLQMHEGKYADAIRSFGNTPSNTLAIAQIMQGQYADATRTLAAVAQPNGETAYLKAVVAARTNDLQALISNLRSAIAQDRSYALRAQRDLEFAAFSQTPEFVALVK
>NC_015501.1|WP_013760355.1|1163938_1165054_-|AMP-binding-protein
MSEHLYIDSVRVDAESLELFAQGLTSERRAVLQPLLAFLREWWSSEECVVVQTSGSTGTPKHIRLTKCAMRRSALRSNRYFHIEAGTRLLLAMNLRYIGAKMMVVRTLLAGAELMVVPPSSHPLATLSVAPQFVSLVPLQLHHTLEVPAERELLSQAEQLIIGGGAIHPAVEAQLSTLPVAAYATYGMTETISHIALRRLNGPHASPLFYPLEGVHLSQGSDGELIIADRLLYPEGPSLTTHDLVELHPDGGFTIEGRADNIINSGGVKISPEPIERQLSATLAIPLAISWVADAALGQKLVLVLEGDSLPEALAKRLDEACEQLLPPYHRPKEIRCVAQLPHNDNGKLDRRVLQQLLGATTTPPLPSPSR
>NC_015501.1|WP_013760356.1|1165127_1166225_-|o-succinylbenzoate-synthase
MSPEESILHLPTLLSQIAERVTISVEPYTLRFRRPAKTSRGEYETKRVYYLRLQSLKQASHVGYGECAPMPQLSCDDLPDYQAVLEQLAGQLAQAPDQFDVVSLRPYPSIAFGLATAINSFLAACHRGEAETTPPFCDTPFTHGEMGIPINGLIWMGDKAYMYEQIQAKLAQGFRCLKLKIGGIDFSEELELLRYVRQHFSPEEMELRVDANGAFAPEVALERLKQLSDFHLHSIEQPIPASNQWDDLAKLTAASPLPIALDEELIGIHTRERKAQLLDEGKPHYIILKPSLHSGVDEWIELAEERGIGWWATSALESNVGLSAIAQWVSQYPIARPQGLGTGALYLNNKPSTLRLVGDQMFFRD
>NC_015501.1|WP_013760357.1|1166231_1167062_-|1,4-dihydroxy-2-naphthoyl-CoA-synthase
MSEKNQRAWKPLKAYEDILFDYYNGIARITINRERYRNAFTPTTTAEMSDALRICREDQSINVVVLTGAGDKAFCSGGDQNVKGRGGYIGKDGVPRLSVLDVQKQIRSIPKPVIAAVNGYAIGGGHVLHVVCDLSIASENAIFGQTGPRVGSFDAGFGSSYLARVVGQKKAREIWFLCRQYSAQEALDMGLVNKVVPLDQLEDEYVQWAEEMMLLSPLALRMIKAGLNAELDGQAGIQELAGDATLLYYLTDEAQEGKNAFLEKRKPNFEQYPKFP
>NC_015501.1|WP_013760358.1|1167058_1168786_-|2-succinyl-5-enolpyruvyl-6-hydroxy-3--cyclohexene-1-carboxylic-acid-synthase
MIPMEDPVISELVALLQAHGVCDVVLCPGSRNAPLVHALSHQLAGATCHSIIDERSAGFYALGLALATHRAVVVCCTSGTAVANLHPAVAEAYYQGVPLIILSADRPERWIGQWAGQTLPQPGLFGSLVRKAVHLPEPHTEEERWYCNRLINEALLAALAPLPGPVQINVPISDPGVSLLPPTLAEHTPGSSDRRPIGMQPGRCIQQLYPCRIDAQAVEPLLQRLVTFERKMILVGQESWSAATSTRKTFPQSLREQFLCIGESLSNSPVSICSLDALLASLSEADRRALQPDLLITLGGHIVSNKMKQYLRTYPPRETWHLSPDSTVVDLFCSLTEQIIAPIGPFLDTLAHGLAGLASSPYARHWRERIDQLPSPTPRYSSLAVVGSLLSHLPEELCVLHLANSSSVRYAELFRKPRRLLTLCNRGTSGIDGSLSTALGFARQRAEERHFIVIGDLSFFYDLNALGLPEVGSNVRVLLLNNQRGSIFQSLPTLEMDRLAQRYITAEHQLQAQGWAESCGWEYLSVHEASELEETITYFVGPAERPRLLEAFVSSEDEIAELQTYFKQLQPREEL
>NC_015501.1|WP_044211331.1|1168801_1169941_-|isochorismate-synthase
MRSITSHKEQRGRSCNGDELTTLVEERMNGCSPFACFRLPGEGRTVREIGLDHPARVVATTAEKLREQEHLAGFLMAPFAVTAETPMLWIEEEQEARVLQLTECDEKALEGFPPVAPIPQALPDSYRTTFDRFMKHLEDGTAEKLVLAHRVELPSIATAQVVTAFDTALTHYPNAFVSLCYTPQAGLWLCATPEMLLRGDGTRWQTVALAGTMPRQRDGEPPLWSEKNRREHRYVQRFIGELLEREGIPYHALAVETTTTGALQHLQARFALQLPDGYAPITLAERLHPTPAICGTPQRVAQRLILEEEPAERSYYAGFLGWYEPERCVDLFVQIRCLQLLPEEALRLYAGGGIVRGSSLESEWQEVLHKLSAIYSLIK

Crispr_ID: NC_015501_6

• CRISPR_ID: NC_015501_6
• CRISPR_location: 1174024-1174097
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_015501_6

Consensus_repeat	Method
GGGACGTACGGTCTGTGCGTCCGT	CRISPRCasFinder

spacers of NC_015501_6

>6.1|1174048|26|NC_015501|CRISPRCasFinder
TGTAGTACAGCGAGACGACTCCTGTA

CRISPR arrays and Neighbor proteins around NC_015501_6

CRISPR arrays

The CRISPR arrays of NC_015501_6

>merge|NC_015501|6|1174024-1174097|CRISPRCasFinder
GGGACGTACGGTCTGTGCGTCCGTTGTAGTACAGCGAGACGACTCCTGTAGGGACGTACGGTCTGTGCGTCCGT

>NC_015501|6|6|1174024-1174097|CRISPRCasFinder
GGGACGTACGGTCTGTGCGTCCGT	TGTAGTACAGCGAGACGACTCCTGTA
GGGACGTACGGTCTGTGCGTCCGT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015501.1|WP_013760355.1|1163938_1165054_-|AMP-binding-protein	unknown	unknown	gnl|CDD|341285
NC_015501.1|WP_013760366.1|1180028_1181381_+|TolC-family-protein	unknown	unknown	gnl|CDD|224455
NC_015501.1|WP_013760368.1|1182538_1183414_+|hypothetical-protein	unknown	unknown	unknown
NC_015501.1|WP_013760361.1|1172403_1172784_-|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	unknown	unknown	gnl|CDD|238269
NC_015501.1|WP_013760363.1|1176047_1177328_+|ABC-transporter-permease	unknown	unknown	gnl|CDD|223650
NC_015501.1|WP_013760364.1|1177356_1178616_+|ABC-transporter-permease	unknown	unknown	gnl|CDD|223650
NC_015501.1|WP_025883318.1|1183433_1183823_+|GntR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224639
NC_015501.1|WP_013760354.1|1159413_1161906_+|YfhO-family-protein	unknown	unknown	gnl|CDD|370572
NC_015501.1|WP_013760360.1|1170076_1172275_-|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	unknown	unknown	gnl|CDD|223394
NC_015501.1|WP_044211331.1|1168801_1169941_-|isochorismate-synthase	unknown	unknown	gnl|CDD|273127
NC_015501.1|WP_013760370.1|1184002_1186576_-|NAD(P)(+)-transhydrogenase-(Re/Si-specific)-subunit-beta	unknown	unknown	gnl|CDD|376743
NC_015501.1|WP_013760358.1|1167058_1168786_-|2-succinyl-5-enolpyruvyl-6-hydroxy-3--cyclohexene-1-carboxylic-acid-synthase	unknown	unknown	gnl|CDD|272941
NC_015501.1|WP_013760356.1|1165127_1166225_-|o-succinylbenzoate-synthase	unknown	unknown	gnl|CDD|239436
NC_015501.1|WP_013760357.1|1166231_1167062_-|1,4-dihydroxy-2-naphthoyl-CoA-synthase	unknown	unknown	gnl|CDD|180958
NC_015501.1|WP_013760367.1|1181624_1182542_+|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|224054
NC_015501.1|WP_004330419.1|1175312_1176032_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|213222
NC_015501.1|WP_013760365.1|1178661_1179774_+|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl|CDD|273776
NC_015501.1|WP_004331037.1|1186572_1186881_-|NAD(P)-transhydrogenase-subunit-alpha	unknown	unknown	gnl|CDD|378941
NC_015501.1|WP_013760362.1|1172808_1173906_-|bifunctional-3-deoxy-7-phosphoheptulonate-synthase/chorismate-mutase-type-II	unknown	unknown	gnl|CDD|225431
NC_015501.1|WP_004330414.1|1161930_1163619_+|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|276809

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015501.1|WP_013760355.1|1163938_1165054_-|AMP-binding-protein	gnl|CDD|341285	cd17630, OSB_MenE-like, O-succinylbenzoic acid-CoA ligase. This family contains O-succinylbenzoyl-CoA (OSB-CoA) synthetase (also known as O-succinylbenzoic acid CoA ligase) that belongs to the ANL superfamily and catalyzes the ligation of CoA to o-succinylbenzoate (OSB). It includes MenE in the bacterial menaquinone biosynthesis pathway which is a promising target for the development of novel antibacterial agents. MenE catalyzes CoA ligation via an acyl-adenylate intermediate; tight-binding inhibitors of MenE based on stable acyl-sulfonyladenosine analogs of this intermediate provide a pathway toward the development of optimized MenE inhibitors.	6.10097e-63
NC_015501.1|WP_013760366.1|1180028_1181381_+|TolC-family-protein	gnl|CDD|224455	COG1538, TolC, Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion].	2.99176e-37
NC_015501.1|WP_013760361.1|1172403_1172784_-|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	gnl|CDD|238269	cd00483, HPPK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a carrier-mediated active transport system. Most microbes and plants lack this system and must synthesize folates de novo from guanosine triphosphate. One enzyme from this pathway is HPPK which catalyzes pyrophosphoryl transfer from ATP to 6-hydroxymethyl-7,8-dihydropterin (HP). The functional enzyme is a monomer. Mammals lack many of the enzymes in the folate pathway including, HPPK.	4.87739e-12
NC_015501.1|WP_013760363.1|1176047_1177328_+|ABC-transporter-permease	gnl|CDD|223650	COG0577, SalY, ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms].	4.021e-27
NC_015501.1|WP_013760364.1|1177356_1178616_+|ABC-transporter-permease	gnl|CDD|223650	COG0577, SalY, ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms].	6.16e-31
NC_015501.1|WP_025883318.1|1183433_1183823_+|GntR-family-transcriptional-regulator	gnl|CDD|224639	COG1725, COG1725, Predicted transcriptional regulators [Transcription].	1.64768e-26
NC_015501.1|WP_013760354.1|1159413_1161906_+|YfhO-family-protein	gnl|CDD|370572	pfam09586, YfhO, Bacterial membrane protein YfhO. This protein is a conserved membrane protein. The yfhO gene is transcribed in Difco sporulation medium and the transcription is affected by the YvrGHb two-component system. Some members of this family have been annotated as glycosyl transferases of the PMT family.	7.83271e-07
NC_015501.1|WP_013760360.1|1170076_1172275_-|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	gnl|CDD|223394	COG0317, SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription].	1.45011e-136
NC_015501.1|WP_044211331.1|1168801_1169941_-|isochorismate-synthase	gnl|CDD|273127	TIGR00543, Salicylate_biosynthesis_isochorismate_synthase, isochorismate synthases. This enzyme interconverts chorismate and isochorismate. In E. coli, different loci encode isochorismate synthases for the pathways of menaquinone biosynthesis and enterobactin biosynthesis (via salicilate) and fail to complement each other. Among isochorismate synthases, the N-terminal domain is poorly conserved. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone].	3.21452e-62
NC_015501.1|WP_013760370.1|1184002_1186576_-|NAD(P)(+)-transhydrogenase-(Re/Si-specific)-subunit-beta	gnl|CDD|376743	pfam02233, PNTB, NAD(P) transhydrogenase beta subunit. This family corresponds to the beta subunit of NADP transhydrogenase in prokaryotes, and either the protein N- or C terminal in eukaryotes. The domain is often found in conjunction with pfam01262. Pyridine nucleotide transhydrogenase catalyzes the reduction of NAD+ to NADPH. A complete loss of activity occurs upon mutation of Gly314 in E. coli.	0
NC_015501.1|WP_013760358.1|1167058_1168786_-|2-succinyl-5-enolpyruvyl-6-hydroxy-3--cyclohexene-1-carboxylic-acid-synthase	gnl|CDD|272941	TIGR00173, menD, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase. MenD was thought until recently to act as SHCHC synthase, but has recently been shown to act instead as SEPHCHC synthase. Conversion of SEPHCHC into SHCHC and pyruvate may occur spontaneously but is catalyzed efficiently, at least in some organisms, by MenH (see TIGR03695). 2-oxoglutarate decarboxylase/SHCHC synthase (menD) is a thiamine pyrophosphate enzyme involved in menaquinone biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone].	7.51124e-127
NC_015501.1|WP_013760356.1|1165127_1166225_-|o-succinylbenzoate-synthase	gnl|CDD|239436	cd03320, OSBS, o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway. Menaquinone is an essential cofactor for anaerobic growth in eubacteria and some archaea. OSBS belongs to the enolase superfamily of enzymes, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion.	4.63201e-66
NC_015501.1|WP_013760357.1|1166231_1167062_-|1,4-dihydroxy-2-naphthoyl-CoA-synthase	gnl|CDD|180958	PRK07396, PRK07396, dihydroxynaphthoic acid synthetase; Validated.	0
NC_015501.1|WP_013760367.1|1181624_1182542_+|ATP-binding-cassette-domain-containing-protein	gnl|CDD|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	5.67556e-55
NC_015501.1|WP_004330419.1|1175312_1176032_+|ABC-transporter-ATP-binding-protein	gnl|CDD|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	1.80876e-109
NC_015501.1|WP_013760365.1|1178661_1179774_+|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl|CDD|273776	TIGR01730, COG0845:_Membrane-fusion_protein, RND family efflux transporter, MFP subunit. This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate].	4.19083e-43
NC_015501.1|WP_004331037.1|1186572_1186881_-|NAD(P)-transhydrogenase-subunit-alpha	gnl|CDD|378941	pfam12769, PNTB_4TM, 4TM region of pyridine nucleotide transhydrogenase, mitoch. PNTB_4TM is the region upstream of family PNTB, pfam02233, that carries four of this transporters transmembrane regions. PNTB is the beta-subunit of pyridine nucleotide transhydrogenase. This family forms part of the Proton-translocating Transhydrogenase (PTH) Family.	8.02198e-31
NC_015501.1|WP_013760362.1|1172808_1173906_-|bifunctional-3-deoxy-7-phosphoheptulonate-synthase/chorismate-mutase-type-II	gnl|CDD|225431	COG2876, AroA, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism].	3.44367e-53
NC_015501.1|WP_004330414.1|1161930_1163619_+|tetratricopeptide-repeat-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	1.16533e-10

Protein sequences

>NC_015501.1|WP_013760362.1|1172808_1173906_-|bifunctional-3-deoxy-7-phosphoheptulonate-synthase/chorismate-mutase-type-II
MDDSSAHSTLEEPPASQMLVAGPCSAESREQLLEVAQGLKAQGVTHFRAALWKPRTRPGSFEGVGVEGLAWLQEVQTSTGLKVGTEVCLPEQVEAVRTAGVDFVWIGARTVSNPFMVEAIAEQLEGATQTVLVKNPISPDAPLWMGALERIKSRGVAQVMAILRGCTPVYTKQLRNSPHWEMIAQLRTLYQKRYGTGEHLPILLDPSHIAGRADLLEAVCRTGLLYPIDGFMIECHCDPEHAWTDARQQITPEQLHQLLESLQHPSDDHEAMLRPMRYQLRDLDAALVELLAERYKLTQTIGRYKTANHLGLYQAEQRAAVEAHYIELATQYGLDPHWAAQLYNLIHDYSLRGQEAVDPEEDNNF
>NC_015501.1|WP_013760361.1|1172403_1172784_-|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase
MKNKAIISIGSNEHRTANVKEVMEILTKHFPTIRFSTPQLTEPMDMPEDAKAFLNLIALFETDLDRETLEAKLKKLETKLGRDHDDDEEGIIPMDLDIIEWNDEVYKPQDMVRPYVVAGLEELDEL
>NC_015501.1|WP_013760360.1|1170076_1172275_-|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase
MPTHHRDDQELMRYLLRTADQLGVASYVAPYRELLERLIREGQYGANAGEDDRETFMEQAEMAQLLCDEIGLGVVSISAVLLEPPYIRGSVTAQEVEELCPPGTLPLIERLAQTHELYHRYDLRQANQGEEFLLTIAEDIRVVLILLVECLNKLVYAKERMDESRRVLLAQVAQVLFVPTAHRLGLYKIKSQMEDLIFKYTDPKHYYEIKELMGQTIVARQEYMEAFVAPIQAKLEELPLRWPYTIKSRSKTFTSIMNKMRNKGVSFEEIHDLSAMRIIIDAPPEEEYEACWLVYSIVTDLYTPNTKRLRDWISQPKANGYESLQITVQGPEGKSVEIQIRTTRMDRIAESGMAAHWRYKGVSGEASLDSQLTSMRQVIEDLAGDKEKASTLASLRVESRDIFVFTPAGQMIRLPKGATVLDFAFAIHSNVGLMAQSAQVNGKRAKLRDKLKNGDVINITTAKNQRPSVDWLQSVTTRKAKNKIRQAIRDQQESGLQAGKELLERRFKNRHLVYQESIFTTLLRKMGYKGNMDFFIDLSEERINVPNFLDQYAELCADAEARAAESRRVAPTPTAIKSTEAPDGREIVVSTADFKGLEYTLASCCNPKMGDEIFAYPSKSGLKIHTRNCPNAIDILGRHGDRVLPARWRGMESSTVVATLYVTALHDAVAIGRVISTLHQADECVLLNEEQQLDGGLWHGTFTFREGERQALFALQAQLQSIKGVQQVRLEQ
>NC_015501.1|WP_044211331.1|1168801_1169941_-|isochorismate-synthase
MRSITSHKEQRGRSCNGDELTTLVEERMNGCSPFACFRLPGEGRTVREIGLDHPARVVATTAEKLREQEHLAGFLMAPFAVTAETPMLWIEEEQEARVLQLTECDEKALEGFPPVAPIPQALPDSYRTTFDRFMKHLEDGTAEKLVLAHRVELPSIATAQVVTAFDTALTHYPNAFVSLCYTPQAGLWLCATPEMLLRGDGTRWQTVALAGTMPRQRDGEPPLWSEKNRREHRYVQRFIGELLEREGIPYHALAVETTTTGALQHLQARFALQLPDGYAPITLAERLHPTPAICGTPQRVAQRLILEEEPAERSYYAGFLGWYEPERCVDLFVQIRCLQLLPEEALRLYAGGGIVRGSSLESEWQEVLHKLSAIYSLIK
>NC_015501.1|WP_013760358.1|1167058_1168786_-|2-succinyl-5-enolpyruvyl-6-hydroxy-3--cyclohexene-1-carboxylic-acid-synthase
MIPMEDPVISELVALLQAHGVCDVVLCPGSRNAPLVHALSHQLAGATCHSIIDERSAGFYALGLALATHRAVVVCCTSGTAVANLHPAVAEAYYQGVPLIILSADRPERWIGQWAGQTLPQPGLFGSLVRKAVHLPEPHTEEERWYCNRLINEALLAALAPLPGPVQINVPISDPGVSLLPPTLAEHTPGSSDRRPIGMQPGRCIQQLYPCRIDAQAVEPLLQRLVTFERKMILVGQESWSAATSTRKTFPQSLREQFLCIGESLSNSPVSICSLDALLASLSEADRRALQPDLLITLGGHIVSNKMKQYLRTYPPRETWHLSPDSTVVDLFCSLTEQIIAPIGPFLDTLAHGLAGLASSPYARHWRERIDQLPSPTPRYSSLAVVGSLLSHLPEELCVLHLANSSSVRYAELFRKPRRLLTLCNRGTSGIDGSLSTALGFARQRAEERHFIVIGDLSFFYDLNALGLPEVGSNVRVLLLNNQRGSIFQSLPTLEMDRLAQRYITAEHQLQAQGWAESCGWEYLSVHEASELEETITYFVGPAERPRLLEAFVSSEDEIAELQTYFKQLQPREEL
>NC_015501.1|WP_013760357.1|1166231_1167062_-|1,4-dihydroxy-2-naphthoyl-CoA-synthase
MSEKNQRAWKPLKAYEDILFDYYNGIARITINRERYRNAFTPTTTAEMSDALRICREDQSINVVVLTGAGDKAFCSGGDQNVKGRGGYIGKDGVPRLSVLDVQKQIRSIPKPVIAAVNGYAIGGGHVLHVVCDLSIASENAIFGQTGPRVGSFDAGFGSSYLARVVGQKKAREIWFLCRQYSAQEALDMGLVNKVVPLDQLEDEYVQWAEEMMLLSPLALRMIKAGLNAELDGQAGIQELAGDATLLYYLTDEAQEGKNAFLEKRKPNFEQYPKFP
>NC_015501.1|WP_013760356.1|1165127_1166225_-|o-succinylbenzoate-synthase
MSPEESILHLPTLLSQIAERVTISVEPYTLRFRRPAKTSRGEYETKRVYYLRLQSLKQASHVGYGECAPMPQLSCDDLPDYQAVLEQLAGQLAQAPDQFDVVSLRPYPSIAFGLATAINSFLAACHRGEAETTPPFCDTPFTHGEMGIPINGLIWMGDKAYMYEQIQAKLAQGFRCLKLKIGGIDFSEELELLRYVRQHFSPEEMELRVDANGAFAPEVALERLKQLSDFHLHSIEQPIPASNQWDDLAKLTAASPLPIALDEELIGIHTRERKAQLLDEGKPHYIILKPSLHSGVDEWIELAEERGIGWWATSALESNVGLSAIAQWVSQYPIARPQGLGTGALYLNNKPSTLRLVGDQMFFRD
>NC_015501.1|WP_013760355.1|1163938_1165054_-|AMP-binding-protein
MSEHLYIDSVRVDAESLELFAQGLTSERRAVLQPLLAFLREWWSSEECVVVQTSGSTGTPKHIRLTKCAMRRSALRSNRYFHIEAGTRLLLAMNLRYIGAKMMVVRTLLAGAELMVVPPSSHPLATLSVAPQFVSLVPLQLHHTLEVPAERELLSQAEQLIIGGGAIHPAVEAQLSTLPVAAYATYGMTETISHIALRRLNGPHASPLFYPLEGVHLSQGSDGELIIADRLLYPEGPSLTTHDLVELHPDGGFTIEGRADNIINSGGVKISPEPIERQLSATLAIPLAISWVADAALGQKLVLVLEGDSLPEALAKRLDEACEQLLPPYHRPKEIRCVAQLPHNDNGKLDRRVLQQLLGATTTPPLPSPSR
>NC_015501.1|WP_004330414.1|1161930_1163619_+|tetratricopeptide-repeat-protein
MTYRNLLKITTALLLAVLVSSCACRLKPLNGSAAQVDPNPLTLVGTQIPGQVRLTLPAKWCHKRAIVNITPQLRYAGTSVTGQTVTIQGENVRDNYQTISYERGGSVIVPFAFEYKPGMEQSDLYLTFTATIKGKKVNLPAIKVARGTIMTAGLASISDVTPALARDAFQRVIKEQYTADLKFLINRAEVRAAELNKREVKDWQDVVDNAYQVPNQEVDIEIQAYASPDGAQDFNERLSAQRERNTSSVVARQLGKKKIEVNAHYTAEDWDGFQKLLEASNIQDKELVLRVLSMYPDPEDREREIRNLSHVFTQLADEILPELRRSRLNANVRIIGKSDDELKMFMAQRPGRLTIEEILYTATLYDNAKDQMNAYQQATQLYPKDYRAYNNIGTLYLAQGNYEQAANYFAKAQKIQPNAASNMNEALLALNRGDLAEAQRLMGSAVEVPEAGQGIGLLQMHEGKYADAIRSFGNTPSNTLAIAQIMQGQYADATRTLAAVAQPNGETAYLKAVVAARTNDLQALISNLRSAIAQDRSYALRAQRDLEFAAFSQTPEFVALVK
>NC_015501.1|WP_013760354.1|1159413_1161906_+|YfhO-family-protein
MKQIPWQRILLIFGFFIIVALGYFTPAHFEGRTLFQADVAGVSGNGSDVQASDETSYWTNSLFGGMPMYQISPSYPSTKPLQYLQDVLTLRKPLSILGTYPWLIFALLVGFYIFMRSLKVDPLPSVLGAVMWALSSYFIILIQAGHIWKLTALCFVPPTIAGLIWCYRGERLWGGALFAFFMALQLLANHVQMTYYFALLMAVLVMTFLVQAIRERQVVDFLKSTGVLILAGLLAIAVNGTNLYHTYQYAQETMRGGSELTIALPHAPEQTGAEVNSKGLSKEYITQWSYGIGETWTLLVPNTKGGATESLAQGHAKQLAKAPYEYQQMLGQMNAYWGDQPFTSGPVYVGAFVCILFIIGCVIVKGPIKWGLLVATILSILLAWGKNFMPLTDLFIDWMPMYDKFRAVSSILVIAELTIPTLAVLALVQLIKEPRLLRSKRVWIAGGVPVLLLLLFALLPDLFFGFLSQQEKGMFAELATQDPRYLMLQDQLETMRMGIFRADVWRSLLFIVLSVVPLWLFAKGYLKAPWLCCILVGLTLVDLWQVDKRYLSDDDFISSRLVQQQAAPMTEADRAILQDKSLGYRVFNQTVNSFNDATTSRWHHSVGGYHAAKLQRYQDLITYQLSTGNMQVYDMLNTKYFIVPNPETKAPMAVTNPDAFGAAWFVDSLRWVANANEEMEALSTADLRHVGIVDRRFGEELPQPLMLPDSTAQRSITVSKYTPRQVVYDVSAEAPGVAILSDIYYPHGWHATIDGQEIPIARANYVLRAVSLPAGNYQLALTFAPRSITVTESIAFTALALILLALIGSIVWRIRPWGKGKKASTDSQTN
>NC_015501.1|WP_004330419.1|1175312_1176032_+|ABC-transporter-ATP-binding-protein
MNAKPVISLRNLHKTYQGAQPLHVLKGINLDIFPGEMVAIMGASGSGKSTLLNILGLLDSYDEGSYHLGEELLSNSLSENRAAEIRSRQIGFVFQSFNLIPFKNALDNIALPLFYQGVGRKERTKRAAELLARMGLADWAEHLPSEMSGGQKQRIAIARALITTPSVILADEPTGALDSKTTIEVMELLREINRESHLTMIIVTHEPGVAEMCDRTIHIKDGLIEGGGLTSSLPEEVFE
>NC_015501.1|WP_013760363.1|1176047_1177328_+|ABC-transporter-permease
MRIGHEYFSEIIDNLKRNRLRTFLTGFAVAWGIIFLVILLSIGVGLNRGISKSANAGDTEPNYGIYFGVWMTNLPYQGYPAGRWLFLAESQFAQLQEMVPAIEDITPRFRSWNKITYASQVTEGSVKGIGANYFGHFETRVKMLAGRSINGNDVYNREKTLLISSSDALKLFGTDQYGEALGKIVSVDNVSFTVVGVYEAQQNQSASYMPSSTFTMIDSNDQRIDGGYIYAPTIRSKKDFEAFDKELLKALSSILSFSPDDDQAMYSYSNYVNNEQYNKVVNYFYLFLWIVGLSTLLIGIVGVSNIMLVTVRERYKEIGIRKALGAKPRDILAMIMVESLLITAVAGAIGLVIAVGLVALGDYLVTAYHIGEFSIMGETIHLFDTPVLSPQMALGILVVMIIAGIVAGYTPARRAIRISAIEAMRD
>NC_015501.1|WP_013760364.1|1177356_1178616_+|ABC-transporter-permease
MRLFDRDIWGEAFHSLRTNRKRSIATAFGIFWGILMLVILMSLSQGFSNGMRKQLGGISSNTTMLYCSTTSKPYKGYPTDRWWSLSVSDIDNLQKRFPEIETISPIQQGAWDTAVSYGTKSTTAPLYSAWTSYDQIVYSTLLAGRRLNESDEQQRRRNCTIGEEVSQKFFASHEEALGKVINIDGSYYTVVGVLKGKSKGMNINGSEEQKVRIPYTILSASLGQSNEVYHFLYSLHGDGKDSKAINDRIKAYIRSTHDIAPDDESAIGEFNISEIFTAQNSMLWGVNVFVWFIGIGTLLSGIIGISNIMLVSVKERTREIGIRRALGAQRKDIIRLILLESGMLSLLAGLLGLLLGVGIMSIVSQITASMENEMLVNPLIPFGTAIGALLFIVIGGVVGGLLPLKKALEIRSIEAIREE
>NC_015501.1|WP_013760365.1|1178661_1179774_+|efflux-RND-transporter-periplasmic-adaptor-subunit
MKAKRIFKLSLWVIFGLLVVMTFVFLYKKAQPQATIYSVETVTRVPSIQRSIILTGKIAPRNEVMIVPQLNGIIAEIMKKPGDLVKAGDIIARIKVVPEMGSVNQAESQVEIAKIALDEAEQKYKIATELHQQGIVAEEEYATTKANYLQAKERLASAKDAYNIVLTGMSQRNAQGSTTLVRSTVDGTILDIPVKEGNSVIQANSFNAGTTIATIADMTEMIFIGKVDEVDIARVATGLPVTVRIGAIEGSAFSGVVEYISPKTIQQQQGTQYELKAAITIDDYSRIRSDMSANAELITDQVSNVLAVPEGALQFEGDKVYVEVVTSDADPKHLETERREIKTGISNGSLIEVKSGLKEGEKVKGTPVAA
>NC_015501.1|WP_013760366.1|1180028_1181381_+|TolC-family-protein
MLTLRHIFPLALLVAGSFTLAAQQSWTLQQCIDHAVAHSITVEEARLRLAGSEQQLSTAQHSYLPSLSASASQSVSLGRSADKTGVIGDQSSSSTSFGANLSWDVFSGMARPKATEIARLNLDAATAGLSYAKEQIGLQVAEGYYNLLFRQELIHVADEQLKLTRETLTKTAAMVQAGKWSRDKLAEVEAQLAKDSVNYLRACSDTELARHQLALIIELPDYTELQITLPDVKSLSATPAPELALADDALLEQARTMRPEMEQARLQLQVAERQIGLEQTGYIPKVSFGAGYNTGYYYILNKELRQYNQPFGDQMRNNGRYFVGLSLSVPIFDAMRTADNVAQARLRYSDQQIALRKVDKELTQQLYTAQINARAAYSQIAAAERATESAETALHYAQISYEAGRASSYELAEAQNRHFVAQSEELRARYDYLYRVLVLHSYISPAEETK
>NC_015501.1|WP_013760367.1|1181624_1182542_+|ATP-binding-cassette-domain-containing-protein
MYSNSDTHLTAEPLVQAQEVCFSYGRHPLFRSVSFTLPAGSITGLLGKNGEGKTTLLKLLSGLLLAKGGELSVLGHSSRKRSVPLLRELYYLPEEVQLPATSAVQYLDGAGQFYPNYDATLARQLLQDFDVPPTNNLRRLSMGQKKKVALVLALSLRVPLLLLDEPTNGLDIPSKSKFRQLLVQHISDEQTVLISTHQVRDLEQMIDRLVVLHQNQIICNETIARLESTFYCGTAAEAPHVAPLYSEPSVWGEVVMTPRTPETAETGGFSMELFFNALMYNTQAVLQHLSQPANDTLTPQAPLSL
>NC_015501.1|WP_013760368.1|1182538_1183414_+|hypothetical-protein
MNQSANLTTAAPKTGVSSFSFKRLGQLLRLDFAFHHRQWLQILIGGFLAASIPVIVSALSGLLFGMGWSANEARSLYLACLYCSFLAVSLGAMISYNQRVNASLSPLYLQIPASATEKYISLLLLTLALQIITPFLGAVAWTVYMLIWALVDGSQVLALYSEALTDPLNYDNTLLQYGWSLSLMIAMQLAGYATYLYCIISARKPLRAVLRFMGIGFVIFIVSVLGVSMLMHLLDIGSIRPDDTLRYLVFYLGNGDELSISLLALTIPIYLYAFAMVWLGLRSLRRKQVTA
>NC_015501.1|WP_025883318.1|1183433_1183823_+|GntR-family-transcriptional-regulator
MITPRFNPQVVIYAQIEQRIKEKILSGEYPAGTQIPSVRQLAAELETNANTIFRAYENLQNEGLIYPKKGLGLYVSETAEMLLRDEAYRVLTEEELPELFAQLKVLNMDILEVVRRHADWVKQQGDPDA
>NC_015501.1|WP_013760370.1|1184002_1186576_-|NAD(P)(+)-transhydrogenase-(Re/Si-specific)-subunit-beta
MNTLIEISNPVYYVICAVLSILVLVGIAMMSKVKTAARGNALSATAMGLGVLVTLLKLQVVTFPWLIGGILIGGIIGVLLYTRVKMIQMPQMVALLNGIGGGASALVGALTLFQLPVSNVYFTLVTAFLAIIIGMLTLVGSLVAAGKLHRVLPQKSVVWPFHNVATSLTLVVAVFFLLIGTLNYVVPSALIYAMIGTMLFSALFGLYFSIRVGGADMPITISLLNSLSGVAGAIAGMAIGDIFLVAVGGVVGASGLLLTQIMCRAMNRSLINILIPHGKAKAPAKATAPAKAAAPAPKAPAAPQPKQESSPIDQAVAMLRGAKRVIIVPGYGMALAQAQQEVKQLADKLARGGADVKYAIHPVAGRMPGHMNVLLAEANVDYDSLYEMEAINDQFANTDAVIVIGANDVLNPAARNAEGTPIYGMPVLNVDQAKQVIICNFDLKPGYAGVENPLYSRGEGVALCLGDAKATIDQILSGLESSAATAQPASSSSASDPISQAADMLRGAKRVIIVPGYGMALAQAQQEVKQLADKLAKSGADVKYAIHPVAGRMPGHMNVLLAEANVDYDSLYEMEAINDQFANTDAVIVIGANDVLNPAARNAEGTPIYGMPVLNVDQAKQVIICNFDLKPGYAGVENPLYSRGEGVALCLGDAKATLSNLMDRLDHAESTPVAPAASSASSATSSATPLQSATEVLHNAKSVIIVPGYGMALAQAQQEVKQLADKLAKGGADVKYAIHPVAGRMPGHMNVLLAEANVDYDSLYEMEAINDQFANTDAVIVIGANDVLNPAARNAEGTPIYGMPVLNVDQAKQVIICNYDLKPGYAGVENPLYSRGEGVTLLIGDAKKTLSDLIDTL
>NC_015501.1|WP_004331037.1|1186572_1186881_-|NAD(P)-transhydrogenase-subunit-alpha
MNPLILVAIFLVATFVGYKLISNVPSLLHTPLMSGMNALSGVTITGALAATATAIIAPDGSLFQQIFGVIAVILATINVVGGFGVTNRMLRMFTKNKKGGKA

Crispr_ID: NC_015501_7

• CRISPR_ID: NC_015501_7
• CRISPR_location: 1870857-1870995
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_015501_7

Consensus_repeat	Method
TCTCCACGTGGATATTTTTTATTCTCCACGT	CRISPRCasFinder

spacers of NC_015501_7

>7.1|1870888|77|NC_015501|CRISPRCasFinder
GGATATTTTTTATTCTCCACGTAGGTACGAAACGATTCCTCCGAAGTTTCATTTGATTCCTCCGAAGTTTCATTTCA

CRISPR arrays and Neighbor proteins around NC_015501_7

CRISPR arrays

The CRISPR arrays of NC_015501_7

>merge|NC_015501|7|1870857-1870995|CRISPRCasFinder
TATCCACGTGGGAATTCTCAATTCTCCACGTGGATATTTTTTATTCTCCACGTAGGTACGAAACGATTCCTCCGAAGTTTCATTTGATTCCTCCGAAGTTTCATTTCATCTCCACGTGGAGATTTTTTATTCTCCACGT

>NC_015501|7|7|1870857-1870995|CRISPRCasFinder
TATCCACGTGGGAATTCTCAATTCTCCACGT	GGATATTTTTTATTCTCCACGTAGGTACGAAACGATTCCTCCGAAGTTTCATTTGATTCCTCCGAAGTTTCATTTCA
TCTCCACGTGGAGATTTTTTATTCTCCACGT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015501.1|WP_004331214.1|1866502_1867687_+|universal-stress-protein	unknown	unknown	gnl|CDD|238182
NC_015501.1|WP_013760755.1|1873359_1874145_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl|CDD|153251
NC_015501.1|WP_013760752.1|1868425_1868998_-|DUF4252-domain-containing-protein	unknown	unknown	gnl|CDD|379445
NC_015501.1|WP_013760760.1|1880054_1881245_+|hypothetical-protein	unknown	unknown	unknown
NC_015501.1|WP_013760757.1|1876470_1878138_+|sulfatase-like-hydrolase/transferase	unknown	unknown	gnl|CDD|293741
NC_015501.1|WP_004331209.1|1864013_1865963_+|glycoside-hydrolase-family-92-protein	unknown	unknown	gnl|CDD|226067
NC_015501.1|WP_044211435.1|1878318_1879110_+|nucleoside-triphosphate-pyrophosphohydrolase	unknown	unknown	gnl|CDD|236569
NC_015501.1|WP_004331238.1|1861586_1863125_+|AMP-binding-protein	unknown	unknown	gnl|CDD|236097
NC_015501.1|WP_013760750.1|1859109_1860516_+|C1-family-peptidase	unknown	unknown	gnl|CDD|238328
NC_015501.1|WP_013760753.1|1869477_1870707_-|SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|380115
NC_015501.1|WP_004331221.1|1871252_1871846_+|30S-ribosomal-protein-S16	unknown	unknown	gnl|CDD|237744
NC_015501.1|WP_004331226.1|1863108_1863462_+|hypothetical-protein	unknown	unknown	unknown
NC_015501.1|WP_013760754.1|1872005_1873250_+|insulinase-family-protein	unknown	unknown	gnl|CDD|223685
NC_015501.1|WP_004331232.1|1863726_1864017_+|DUF721-domain-containing-protein	unknown	unknown	gnl|CDD|377496
NC_015501.1|WP_004331215.1|1874125_1874635_+|low-molecular-weight-phosphotyrosine-protein-phosphatase	unknown	unknown	gnl|CDD|319971
NC_015501.1|WP_004331210.1|1866123_1866384_+|hypothetical-protein	unknown	unknown	unknown
NC_015501.1|WP_013760756.1|1874710_1876474_+|phosphoethanolamine-transferase	unknown	unknown	gnl|CDD|293741
NC_015501.1|WP_155811510.1|1860822_1861590_+|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|235631
NC_015501.1|WP_013760761.1|1881344_1883621_+|NADP-dependent-malic-enzyme	unknown	unknown	gnl|CDD|235976
NC_015501.1|WP_013760759.1|1879122_1880055_+|methyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|372616

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015501.1|WP_004331214.1|1866502_1867687_+|universal-stress-protein	gnl|CDD|238182	cd00293, USP_Like, Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, athough Usp lacks ATP-binding activity.	1.33067e-19
NC_015501.1|WP_013760755.1|1873359_1874145_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl|CDD|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	4.02125e-54
NC_015501.1|WP_013760752.1|1868425_1868998_-|DUF4252-domain-containing-protein	gnl|CDD|379445	pfam14060, DUF4252, Domain of unknown function (DUF4252). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 154 and 182 amino acids in length.	1.3629e-17
NC_015501.1|WP_013760757.1|1876470_1878138_+|sulfatase-like-hydrolase/transferase	gnl|CDD|293741	cd16017, LptA, Lipooligosaccharide Phosphoethanolamine Transferase A (LptA) or Lipid A Phosphoethanolamine Transferase. Lipooligosaccharide Phosphoethanolamine Transferase A (LptA) or Lipid A Phosphoethanolamine Transferase catalyzes the modification of the lipid A headgroups by phosphoethanolamine (PEA) or 4-amino-arabinose residues. Lipopolysaccharides, also called endotoxins, protect bacterial pathogens from antimicrobial peptides and have roles in virulence. The PEA modified lipid A increases resistance to the cationic cyclic polypeptide antibiotic, polymyxin. Lipid A PEA transferases usually consist of a transmembrane domain anchoring the enzyme to the periplasmic face of the cytoplasmic membrane.	2.3533e-29
NC_015501.1|WP_004331209.1|1864013_1865963_+|glycoside-hydrolase-family-92-protein	gnl|CDD|226067	COG3537, COG3537, Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism].	9.33255e-44
NC_015501.1|WP_044211435.1|1878318_1879110_+|nucleoside-triphosphate-pyrophosphohydrolase	gnl|CDD|236569	PRK09562, mazG, nucleoside triphosphate pyrophosphohydrolase; Reviewed.	1.55277e-128
NC_015501.1|WP_004331238.1|1861586_1863125_+|AMP-binding-protein	gnl|CDD|236097	PRK07788, PRK07788, acyl-CoA synthetase; Validated.	3.92715e-89
NC_015501.1|WP_013760750.1|1859109_1860516_+|C1-family-peptidase	gnl|CDD|238328	cd00585, Peptidase_C1B, Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is a cysteine peptidase that detoxifies bleomycin by hydrolysis of an amide group. It acts as a carboxypeptidase on its C-terminus to convert itself into an aminopeptidase and peptide ligase. BH is found in all tissues in mammals as well as in many other eukaryotes. Bleomycin, a glycopeptide derived from the fungus Streptomyces verticullus, is an effective anticancer drug due to its ability to induce DNA strand breaks. Human BH is the major cause of tumor cell resistance to bleomycin chemotherapy, and is also genetically linked to Alzheimer's disease. In addition to its peptidase activity, the yeast BH (Gal6) binds DNA and acts as a repressor in the Gal4 regulatory system. BH forms a hexameric ring barrel structure with the active sites imbedded in the central channel. The bacterial homolog of BH, called pepC, is a cysteine aminopeptidase possessing broad specificity. Although its crystal structure has not been solved, biochemical analysis shows that pepC also forms a hexamer. .	0
NC_015501.1|WP_013760753.1|1869477_1870707_-|SAM-dependent-methyltransferase	gnl|CDD|380115	pfam18096, Thump_like, THUMP domain-like. This is a domain of unknown function found in bacteria.	1.3065e-08
NC_015501.1|WP_004331221.1|1871252_1871846_+|30S-ribosomal-protein-S16	gnl|CDD|237744	PRK14521, rpsP, 30S ribosomal protein S16; Provisional.	1.72118e-68
NC_015501.1|WP_004331232.1|1863726_1864017_+|DUF721-domain-containing-protein	gnl|CDD|377496	pfam05258, DUF721, Protein of unknown function (DUF721). This family contains several actinomycete proteins of unknown function.	5.95003e-07
NC_015501.1|WP_004331215.1|1874125_1874635_+|low-molecular-weight-phosphotyrosine-protein-phosphatase	gnl|CDD|319971	cd16343, LMWPTP, Low molecular weight protein tyrosine phosphatase. Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.	1.1531e-69
NC_015501.1|WP_013760754.1|1872005_1873250_+|insulinase-family-protein	gnl|CDD|223685	COG0612, PqqL, Predicted Zn-dependent peptidases [General function prediction only].	1.21771e-78
NC_015501.1|WP_013760756.1|1874710_1876474_+|phosphoethanolamine-transferase	gnl|CDD|293741	cd16017, LptA, Lipooligosaccharide Phosphoethanolamine Transferase A (LptA) or Lipid A Phosphoethanolamine Transferase. Lipooligosaccharide Phosphoethanolamine Transferase A (LptA) or Lipid A Phosphoethanolamine Transferase catalyzes the modification of the lipid A headgroups by phosphoethanolamine (PEA) or 4-amino-arabinose residues. Lipopolysaccharides, also called endotoxins, protect bacterial pathogens from antimicrobial peptides and have roles in virulence. The PEA modified lipid A increases resistance to the cationic cyclic polypeptide antibiotic, polymyxin. Lipid A PEA transferases usually consist of a transmembrane domain anchoring the enzyme to the periplasmic face of the cytoplasmic membrane.	1.02914e-78
NC_015501.1|WP_155811510.1|1860822_1861590_+|SDR-family-NAD(P)-dependent-oxidoreductase	gnl|CDD|235631	PRK05866, PRK05866, SDR family oxidoreductase.	8.51841e-56
NC_015501.1|WP_013760761.1|1881344_1883621_+|NADP-dependent-malic-enzyme	gnl|CDD|235976	PRK07232, PRK07232, bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed.	0
NC_015501.1|WP_013760759.1|1879122_1880055_+|methyltransferase-domain-containing-protein	gnl|CDD|372616	pfam13489, Methyltransf_23, Methyltransferase domain. This family appears to be a methyltransferase domain.	1.48959e-16

Protein sequences

>NC_015501.1|WP_013760753.1|1869477_1870707_-|SAM-dependent-methyltransferase
MLSQQQMEQVVALSRQWADRSPDRILFERSELEPELKRQIALQVSLLPKMQRKMPRFAESGGYIPHRVNFEQSSSELTARYKQQLIAPQEHILDMTGGLGIDALAMASVSEQSVIYEIDQTMAEALTYNMHKILQQDHVTVHCGDALAAMERATLEGVTLVYADPARRDMEDPNRRLISMDEYSPSPLQIMSRLQELGYQGRLLLKLSPMLDIQWILEQLPQVCAVHIVQVQDEVKELLVAVSMQRQETDPEIYLAVVDRLGQVSRWSFPYQHLSSVRTAYATKVEEYIHIPQPLLMKSGAFHLIAEEQSLTLLGPNSHIYTSAKASPSPLYKSYKLIEEIDYSKSVLRGKELQALRQHYPALTIMSRHFPLTAQQLKQTLKTDESDTYYLLATTMGERARKLLILTSC
>NC_015501.1|WP_013760752.1|1868425_1868998_-|DUF4252-domain-containing-protein
MKRISLPLLSKLVAMLLVLTVTLGAMAQTSPFKYVDAKALPTAADGVQVFSLNENMLDMIPMESIMKTIKEDSNSSVMANIKTLFKKLKSLDVYIASTPETIDKLQKAFAPMLTPGLHRSIKPLLTVNQSEDNLKVQIVSRESGIWCWRKCPELLISVLDEDEYYIVGLTGDFTPKDIQKLVSSAFPSDK
>NC_015501.1|WP_004331214.1|1866502_1867687_+|universal-stress-protein
MPQDKDQSKLVTVAIHTYEKAQILQSLLQSQGIPATLHNVNTVQPIFSTGVRVRIAERDLPRALAYIEDLKWDLDEAYDDLQEKTELANESPDSAHVAAYKGYVLIPVDFSVYTDKIVKLGFHFAARRQLHVLLMHVYTGTLPQMNFPYGDFTALLPQIQAASNQEAKKAEQQMNELTKEIDAKMSEGTLPEVTYRTTIRDGIPADEILRYAKRNLPAIIIMGTRGKTEDSDYIVGSVAAEIIDRAQAPVLVVPERVAIDDLMQVKHVGVATSFDQRDLVLFNQMMQLMAPLEPEYRLFNVSRSEGKWGDVQLQAIQEYNKQQYPNAHIEWTKLDEGELYAALENFVTEHQVELIVVNTYKRRVLAKLFNPTMARRMLFHAGTPILVMHSNSSQ
>NC_015501.1|WP_004331210.1|1866123_1866384_+|hypothetical-protein
MAKETISFNELRRIKDSLPDGSIHQIAEKLGLRVDTVRNYFGGANYEEGRGAGVHIEAGPEGGIVVIDDNTILNQARAIIGEEPVL
>NC_015501.1|WP_004331209.1|1864013_1865963_+|glycoside-hydrolase-family-92-protein
MKQRPSYLLFHTSKYTLLTMLLLLPLLLSTGCSKVGESVFSSAPLLVDYVDVHQGTWDAEHSEEIFPIVQLPHSLLRIIPFKESLRSARIKGLPLYTPDIDGRPLFYLIPESAHPSQDPSGRLSFDFQEITPYSYHLYLDELQVNVDFSLTSMSGLYDLSSRDYNGRDTRQLSLYIDRRDSTTWEQVGDDAIAAEVAYGGTTPTRIYLYLQLNTNIAQMTSSISPSDTTYEHLTLQLQKPNKRIVAKYAISLISCEQAKRNLTTQIQSFEYSPLVKSARNEWQKILRRVEVSGGTEVNMRKFYTALYRSHLWPVSISEDGQYYSPIDDSVHSDEGITQYSQDDLRYTYETNYPLLMLHAPDMMEEIIVSYLRAIRDSGGQLLETLDLGSVVYTEESPLLFLLTDALAKGLLDQDIKQAFEVLRIAIDAEPERRTGYKLWCLSQLANSIGYTALAREYAELSDTYRPSPGRLSAQQVASILEHPSDATPILLPEGQVNIDSLFSSSLHSLNVDPDLFAFLFTYNLMGRPHDAQKFVRHTIDYFFGVGSFGYPGPDDYGSLSASLVFAMMGLYPVAPGINGYSIVAPSFNEININMGGGRHLTIKAQGASQVNKYISDLTIGGRPRTVYWVKHSQIASGGTISMFLSDAEN
>NC_015501.1|WP_004331232.1|1863726_1864017_+|DUF721-domain-containing-protein
MQRKDPKPLGEIISDWLSESPEVDQGLLELKALQYLRTRFYPLRRQIRELSISDHTLQMRITSASLRQEIRLTQQQLIEQINAQLQYDLIDEIIIR
>NC_015501.1|WP_004331226.1|1863108_1863462_+|hypothetical-protein
MKIVRNRWIPFKGFWAINLFGVIFVRKDLPEEHLSDPLWLETIVRHERIHTRQMVELLVIPFYLLYIVEWLVRLAICRDTESAYRSISFEQEAYAHQDDPEYIQQRRLYAFFNYWRR
>NC_015501.1|WP_004331238.1|1861586_1863125_+|AMP-binding-protein
MSRSLLHKLYRLHLLSPSGVARLLHALWCEGVNLMAVTRFAAHYYPSVLAVADEQHHYTYTALYAKARAWAAVLYEQGWRQGMRCALLGRNSSEIVVASLALSRLGVHIYYMSTDLSKEQVRQLCQERQIETALVQEEYADRMPSDLDVKLLDDLNKSDESPGPRRIPKGRGGRIIVLTGGSSGHYKVAARKPSVTAFLHPFLALLREIRLDECRSVYIAPPLYHGFGLASLIVALVMGRSVYLRKRFDAQSATRLLSEHSIEVLIAVPLMLRRLINESPSEIRSLRRILSGGAPLDTPLVRAVEQHWGAVLYNLYGTSEAGFFILATPEILYDAPLALGKPIRGVRCNIVRPDSQGVGVLAVRSGWAMDERKGSWQETGDLVWMDESGVLFLRGRDDSMILSGGENAYPEVLREALAALDAVMDVAVIAYPDLEFGTRLAAFVVLKADHDSTSEEDLRLLLSAKLPRYQMPGRIIRLAVLPRLENGKVAEGTLREMMEVTAQAEERYEDRA
>NC_015501.1|WP_155811510.1|1860822_1861590_+|SDR-family-NAD(P)-dependent-oxidoreductase
MLVEAVQGKTILITGASYGIGEALAHRLAEAGTHLILVARTAERLEALADDLATTAASVQWRSVDLRDEEEVADLITWVRANYSQLDALILNAGKSIHRAFYDSLDRYHDVTRTITTNYTSSVQLIMGLASLLPHGSQIIASNAASTLMPPAPGWSAYQASKSALDSYLRAIRPELRQRGVVVSLLYLPLVRTRMIAPTEMYRSAPALTPEEAAERIACLLCSRRTSFIPWWVRLARPFMSLLRPVFQSIAMRHL
>NC_015501.1|WP_013760750.1|1859109_1860516_+|C1-family-peptidase
MKKLLLPLLLLLSSIMLLAQSESTSRTDGAITPELLQKLQQATPKAPAERALYNSIAQNGMVLANAELMTPPDDHFTYRVPTKGITDQKKSGRCWLFTGFNVLRAQFIKDNNLGEFYFSHCYSFFWDQLEKANLFLEGILETRTLPITDRKVEWLFQHPINDGGQFTGISDNLLKYGVVPSDVMPETYSSNNTARLSSLIAKLLRQGGMELRSKAEQGATLAELRKNKETTLQAIYRLLCLNLGTPPTTFEYTLRDADGKVLSTREYTPLSFYQEHVGVNLKDDYVMIMNDPSQPYYETYAIEYDRHAWDGKDWTYLNLPMEEIKEMAIASLKDGNMMYYSCDVGKELNKESGLLTLGYDDYEAITGVPMTMTKGERIASFDSGSTHAMTLVAVDLDKSGKPTKWMVENSWGATAGHQGYLIMTDEWFDAYTFRLVVHKKYLTPRAKALQGKTPKLLPPWSPMFRAEE
>NC_015501.1|WP_004331221.1|1871252_1871846_+|30S-ribosomal-protein-S16
MATKIRLQRFGRRGYPFYRIVIADSRAPRDGKFIERIGSYNPNTNPATIDLKFDRALYWLKVGAQPSDTVRRILSREGVLLKKHLDGGVAKGAFTQEVADQRFEAWLTNKQQLLKGVAERDQQKAQDIAQKQHEAEEEQNKERSKALEEKKAAIEREKAEAEAAAKAEAEANEEANATEEAPAAEEAPATEEAPAAE
>NC_015501.1|WP_013760754.1|1872005_1873250_+|insulinase-family-protein
MTSPQLQYHTTAQGLRIVYYPIPSQVTYIGYMVQTGSAQDPQPYHGLAHCTEHMLFKGTHKRHALHLVNRVEAVGADLNAFTTKEDTTLHITIPSRYALRAVHLLTDIVLNSYIPTEELSKEQEVIIEEIASYLDAPSERIYDEFEELLFSGTPLAHNILGSEQSVRRISSTVVRRFMDQYYRPDNMVLGIWGKIDFDKAVEMIEHLYSEPRVAAGDPFKVPKVKPTTTPERLIAKTHHYRTNQCHCIIGTHAPSLHNRERYAMTLFNNFIGGPAISSQLNLHLREELGLVYSVEANYTPYLNDGVWNVYLGTGGDTLQQAVEAVHRILDRYVTTPMSMEQLAISKQQIVGQLLLANDQHDSELITMLKSYLYFGRVSSVAEVAERIQAITPEEITETVGRYLTRAQRHTLIYK
>NC_015501.1|WP_013760755.1|1873359_1874145_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MASVCETTPYSSMLLRILYIIYIVLFAAPIYAVITIILALIMTVGCLLGFGKFFSYYPGLIWSWLGLILSLCPVTVRGRKNYDKKSGPYVVMANHQGAYDIFLLYGFLGIPFKWVMKESLRRVPFVGKACEVAGFIFVNGHSIQNIRNSLDEAKRSLGDGYSIFIFPEGSRTRTGRMQPLKKGGFVIADELDIPIIPVSISGSYGVMRAGSFLPHWRRLYLDIHPPIHPRDYRSSDQPMQDLREGVYHTIQQGIHDGTEQL
>NC_015501.1|WP_004331215.1|1874125_1874635_+|low-molecular-weight-phosphotyrosine-protein-phosphatase
MAQSNSSSKAPYRILFVCLGNICRSPLAEAIMRQLLAEDPASSSQIEVDSAGIGGWHQGELADPRMRAHAARRGIEMTHRARQIKDGDFETFDQIIAMDDGNYEALRELAPTLEQQKKVVRMADYLEQMPWDHIPDPYYGGASGFELVLDLLTEGCTNLYHRYETQSDK
>NC_015501.1|WP_013760756.1|1874710_1876474_+|phosphoethanolamine-transferase
MFLKIKRLLSICGGYLKQLLGRMCSMPTLFTFLTLLQVLMGSLMILHLRMEMPLLLWLGGYIAGTAILMTLPAILPKRWWRITWTSLIVLLSAVLFIYEYYLLTEHGTLLTQTVLLQYYTPWADEVCRSLLPWSMPMHTLLEAIGLLCGISLVTWLTNKGWGLLFMILLLLISGIPHATQLSPIVAGGISNEEAYTLAHEYNMMSRYVATTLGVFTNQKRYDEMGQNLWKNTPTNVRLMPQRQPHNVVVIIGESLRRLDMHCYGYPLENTPRLDSLVQAGSLVLYDDVVCPQPNTLTSLRRVLTIRGEDEQAPWDATTTLPITFSSAGYKTYWCSNQEMAGDWIEEVSLIASTADSSYYTDGSTSSALHWKAGRVKHDELILPHLIVYRQTSSPNGSLLVVAHLMGSHASFADRYPNDRFSRFTAKDVKQIEPRLSSGEAQNSAEYMNSILYNDSIVSEIIKYYSQSSSIVIYFSDHAISRYDNPKAPTQAAHGVCESALQIPFMVYMSDQFAAENPDVLLAVQRARYKPFMTDLFTSSLMGLMGIESNYTIPRLQLWSLSYDATRPRCIKGFGSEVTFSPKHPDQL
>NC_015501.1|WP_013760757.1|1876470_1878138_+|sulfatase-like-hydrolase/transferase
MRKALLHYLQGVKARIPQLVWLLIAMLAILTLNNLVIRGLLSRSATYLSRENLPLLWDTLWMATLLYIIPTLIPHRITRRVVLIIELVLISAIHIMDLYLVSTYQMPYCDAIAIPIFATNPGEASGFFKSLRLEMPFMLIEGVKLLVAIFLPLGISWLISRTKRTKEQPTPWDKRIQRYSSTLLFIVVLVGAHILGINYLRQTRIATSAGVIQYNAHAPLARLYLSHRVLRHDAKRCALDYRPRQATPQEVTVDSLLPPHNVVLVVAENIYPHLMHCYNPIVNDNTPVIDSLLQMGSFIRLDSVYSASDNAALAAAWTFSLCPKDSPNSWDTYPSIYSIFRAAGYDTYWLDNTPRIARGLDVYPQLAADCDDHFFTNLRADDQDWTSRIPYDDAVLDQLKQLESQSRLTTIHLLGARSNIWWRIPEEFCKYNRLSANIDIDLSGDALDHLAQYYNVVYYQDDLLKQLIAHYQDTPTILIYCSPVGAYSEWHPYSGDQVAPETRGQVPMLLYLSPAMQRISPTLRDQLLQLNAERHNLSDLPQLLMRLSGIKVSLS
>NC_015501.1|WP_044211435.1|1878318_1879110_+|nucleoside-triphosphate-pyrophosphohydrolase
MIHSKDERLEAFSRLLDVLDNLRTHCPWDRKQTNESLRANTIEEVYELSEALEQGDTNAISKELGDVLLHVLFYARIGDEQGNFDIVDVCNKLCNKLIFRHPHIYATEEVEDAGQVVQLWEQVKQKEKDGNKSVLSGVPSALPALIKAYRIQDKARAVGFDWQEREEVWAKVREELQEVEQEMTSGSADDLEAEIGDLLFSIVNAARLYGVNPDNALERTNRKFIDRFEYIERTAKTRGQSITDLSLEEMETLWKEAKKSTSK
>NC_015501.1|WP_013760759.1|1879122_1880055_+|methyltransferase-domain-containing-protein
MIACSLSDQTCPHCHNSSYTELWECEDHLVSHEHYAIGRCNECGLLQTLTPPPAEELGHYYDSSDYLSHQTEGRGGMARIYRAVKRYRVGRRVRTARKLCATAPQMMLEVGAGVGAFAHAMQEHGCKAYVVEQSKAARQLCAQQIPSEQLFATTQEFVAHHSELFGQLDLICLWHSLEHLPDLADQLEIYQQLLKPGGTLCIAVPNAQSFDASYYRALWAAYDVPRHLWHFTPHSMRQTVEAHHFTLKKIRPQRLDVYYIALLSESYKQGGRINFITWLKAFGVGFSYHIRSLFTPMRASALLYHFVRQA
>NC_015501.1|WP_013760760.1|1880054_1881245_+|hypothetical-protein
MKARQLLGTILLLLAPIPVLCASNVAELSADSLRLSVGVEATTFFRNNEYHADYQLGYTLPGWQLAPTVALEHRQVRLVGGVYNLTLLGAQRYPRGGWYDHLPHWSGDPKKQGRGVHLRPILSLQYRPNDHITVSMGTLLGAQTVALRGVASSTVDQDGSLSLVSPLYDPEYSFTRDPAQGAMIQLRYPRFALEALVDWQGFIFPGETHQEAFSALLSTVYRLHSSDSWKTQLELQATAHHRAGEIQQMSPPDTLHTYLAGATGVTTQYKYAAQGTVEGSLHILGSSLRDGKSEPPLGYGFYGRLAWRHKMLRLATDATYGHRYYAPYGGPLLASARTAEEQWRLGLYPALEVPIPSFGALRLEGALWWSQRTATRSQLSHMISLTLTFCNNWTIL
>NC_015501.1|WP_013760761.1|1881344_1883621_+|NADP-dependent-malic-enzyme
MDKKLEAAARAYHALPQPGKIEVRPTKSHNTQQDLTLAYSPGVAVPCKDIEADPERAYDYTSKGNLVAVISNGTAVLGLGNIGAMAGKPVMEGKGLLFKIYAGIDVFDLEVDEKDPKKFVEIVRSLAPTFGGINLEDIKAPECFEIEEELKATLDIPVMHDDQHGTAIISAAGMLNALKIVGKKIEETKIVVSGAGASAQSCTKLYIALGAKRENIVMIDSKGVIRTDRPNLDERKAFFATSREGIYTLADAIEGADLFLGLSQPGVLTPEMVQKMAPNPIVFALANPEPEIRYEDAKAARPDVLMATGRSDYPNQINNVIGFPYIFRGALDVRATAINEEMKMAATIAIADLAQEPVPDEVSSAYGHMPLHFGPDYFIPKPVDPRLITRVSMAVARAAIRTGVARREITDWEAYEQSLLMRTGGMSHLLRRIHEAAQKSPKRMVYAAGENPLVLRAAAEVAQLGIAHPIVLGDPVVIRELAKEHDLDLSTIEIINQHDEQWKAKREEYARRYTEQNWRKGGILSEAKDKMFGPNYFGMMMVQCGDADSLITGIYSNYAYLSNVARDTVGIAPGHQHFATMHLVMMKSGPLFLADTLINQNLKAETLVDIALLAAEKVRCFGIKPVIAMVSFSDFGSTDAESSVEARKAVEILHRDYPHIVVDGEMQLQTALNYQRRDEEFPNNRIKGEPANVLIFPRLSAANACYQLLKHLDIAEDVIGPIQIGLAKPIYFADHDADVKDIVNITAMASLDSNSCFV

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_015501_4	4.1|980787|21|NC_015501|CRISPRCasFinder	980787-980807	21	NC_015501.1	233609-233629	0	1.0
NC_015501_4	4.1|980787|21|NC_015501|CRISPRCasFinder	980787-980807	21	NC_015501.1	1445842-1445862	0	1.0
NC_015501_4	4.1|980787|21|NC_015501|CRISPRCasFinder	980787-980807	21	NC_015501.1	1513292-1513312	0	1.0
NC_015501_4	4.1|980787|21|NC_015501|CRISPRCasFinder	980787-980807	21	NC_015501.1	1622613-1622633	1	0.952
NC_015501_4	4.1|980787|21|NC_015501|CRISPRCasFinder	980787-980807	21	NC_015501.1	406877-406897	2	0.905
NC_015501_7	7.1|1870888|77|NC_015501|CRISPRCasFinder	1870888-1870964	77	NC_015501.1	1188434-1188510	18	0.766
NC_015501_7	7.1|1870888|77|NC_015501|CRISPRCasFinder	1870888-1870964	77	NC_015501.1	1493703-1493779	18	0.766
NC_015501_7	7.1|1870888|77|NC_015501|CRISPRCasFinder	1870888-1870964	77	NC_015501.1	233507-233583	18	0.766
NC_015501_7	7.1|1870888|77|NC_015501|CRISPRCasFinder	1870888-1870964	77	NC_015501.1	829151-829227	18	0.766
NC_015501_7	7.1|1870888|77|NC_015501|CRISPRCasFinder	1870888-1870964	77	NC_015501.1	599044-599120	18	0.766
NC_015501_7	7.1|1870888|77|NC_015501|CRISPRCasFinder	1870888-1870964	77	NC_015501.1	1848497-1848573	18	0.766
NC_015501_7	7.1|1870888|77|NC_015501|CRISPRCasFinder	1870888-1870964	77	NC_015501.1	105557-105633	19	0.753
NC_015501_7	7.1|1870888|77|NC_015501|CRISPRCasFinder	1870888-1870964	77	NC_015501.1	1513338-1513414	19	0.753
NC_015501_7	7.1|1870888|77|NC_015501|CRISPRCasFinder	1870888-1870964	77	NC_015501.1	201990-202066	19	0.753
NC_015501_7	7.1|1870888|77|NC_015501|CRISPRCasFinder	1870888-1870964	77	NC_015501.1	1466205-1466281	19	0.753

1. spacer 4.1|980787|21|NC_015501|CRISPRCasFinder matches to position: 233609-233629, mismatch: 0, identity: 1.0

aattctcaaatctccacgtga	CRISPR spacer
aattctcaaatctccacgtga	Protospacer
*********************

2. spacer 4.1|980787|21|NC_015501|CRISPRCasFinder matches to position: 1445842-1445862, mismatch: 0, identity: 1.0

aattctcaaatctccacgtga	CRISPR spacer
aattctcaaatctccacgtga	Protospacer
*********************

3. spacer 4.1|980787|21|NC_015501|CRISPRCasFinder matches to position: 1513292-1513312, mismatch: 0, identity: 1.0

aattctcaaatctccacgtga	CRISPR spacer
aattctcaaatctccacgtga	Protospacer
*********************

4. spacer 4.1|980787|21|NC_015501|CRISPRCasFinder matches to position: 1622613-1622633, mismatch: 1, identity: 0.952

aattctcaaatctccacgtga	CRISPR spacer
aattctcaaatccccacgtga	Protospacer
************.********

5. spacer 4.1|980787|21|NC_015501|CRISPRCasFinder matches to position: 406877-406897, mismatch: 2, identity: 0.905

aattctcaaatctccacgtga	CRISPR spacer
aaatcccaaatctccacgtga	Protospacer
** **.***************

6. spacer 7.1|1870888|77|NC_015501|CRISPRCasFinder matches to position: 1188434-1188510, mismatch: 18, identity: 0.766

ggatattttttattctccacgtaggtacgaaacgattcctccgaagtttcatttgattcc	CRISPR spacer
ggatattttttattctccacgtagggacgaaacgattcctccgaagtttcatttgattcc	Protospacer
************************* **********************************

7. spacer 7.1|1870888|77|NC_015501|CRISPRCasFinder matches to position: 1493703-1493779, mismatch: 18, identity: 0.766

ggatattttttattctccacgtaggtacgaaacgattcctccgaagtttcatttgattcc	CRISPR spacer
ggatattttttattctccacgtagggacgaaacgattcctccgaagtttcatttgattcc	Protospacer
************************* **********************************

8. spacer 7.1|1870888|77|NC_015501|CRISPRCasFinder matches to position: 233507-233583, mismatch: 18, identity: 0.766

ggatattttttattctccacgtaggtacgaaacgattcctccgaagtttcatttgattcc	CRISPR spacer
ggatatttttgattctccacgtaggtacgaaacgattcctccgaagtttcatttgattcc	Protospacer
********** *************************************************

9. spacer 7.1|1870888|77|NC_015501|CRISPRCasFinder matches to position: 829151-829227, mismatch: 18, identity: 0.766

ggatattttttattctccacgtaggtacgaaacgattcctccgaagtttcatttgattcc	CRISPR spacer
ggatattttttattctccacgtagggacgaaacgattcctccgaagtttcatttgattcc	Protospacer
************************* **********************************

10. spacer 7.1|1870888|77|NC_015501|CRISPRCasFinder matches to position: 599044-599120, mismatch: 18, identity: 0.766

ggatattttttattctccacgtaggtacgaaacgattcctccgaagtttcatttgattcc	CRISPR spacer
ggatattttttattctccacgtagggacgaaacgattcctccgaagtttcatttgattcc	Protospacer
************************* **********************************

11. spacer 7.1|1870888|77|NC_015501|CRISPRCasFinder matches to position: 1848497-1848573, mismatch: 18, identity: 0.766

ggatattttttattctccacgtaggtacgaaacgattcctccgaagtttcatttgattcc	CRISPR spacer
ggatattttttattctccacgtagggacgaaacgattcctccgaagtttcatttgattcc	Protospacer
************************* **********************************

12. spacer 7.1|1870888|77|NC_015501|CRISPRCasFinder matches to position: 105557-105633, mismatch: 19, identity: 0.753

ggatattttttattctccacgtaggtacgaaacgattcctccgaagtttcatttgattcc	CRISPR spacer
ggatattttttattctccacggagggacgaaacgattcctccgaagtttcatttgattcc	Protospacer
********************* *** **********************************

13. spacer 7.1|1870888|77|NC_015501|CRISPRCasFinder matches to position: 1513338-1513414, mismatch: 19, identity: 0.753

ggatattttttattctccacgtaggtacgaaacgattcctccgaagtttcatttgattcc	CRISPR spacer
ggatattttttattctccacgtagggacgaaacgattcctccgaagtttcgtttgattcc	Protospacer
************************* ************************.*********

14. spacer 7.1|1870888|77|NC_015501|CRISPRCasFinder matches to position: 201990-202066, mismatch: 19, identity: 0.753

ggatattttttattctccacgtaggtacgaaacgattcctccgaagtttcatttgattcc	CRISPR spacer
ggatatttttcattctccacgtagggacgaaacgattcctccgaagtttcatttgattcc	Protospacer
**********.************** **********************************

15. spacer 7.1|1870888|77|NC_015501|CRISPRCasFinder matches to position: 1466205-1466281, mismatch: 19, identity: 0.753

ggatattttttattctccacgtaggtacgaaacgattcctccgaagtttcatttgattcc	CRISPR spacer
ggatattttttattctccacgtagggacgaaacgattcctccgaagtttcatttcattcc	Protospacer
************************* **************************** *****

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_015501_1	1.1|306579|27|NC_015501|CRISPRCasFinder	306579-306605	27	NZ_KX348146	Klebsiella pneumoniae strain Kp46 plasmid pKPC_Kp46, complete sequence	29030-29056	6	0.778
NC_015501_1	1.1|306579|27|NC_015501|CRISPRCasFinder	306579-306605	27	NZ_CP036437	Citrobacter sp. ABFQG plasmid pKPC-e4b7, complete sequence	21807-21833	6	0.778
NC_015501_1	1.1|306579|27|NC_015501|CRISPRCasFinder	306579-306605	27	NZ_CP036440	Klebsiella pneumoniae strain ABFQB plasmid pKPC-e4b7, complete sequence	28001-28027	6	0.778
NC_015501_1	1.1|306579|27|NC_015501|CRISPRCasFinder	306579-306605	27	NZ_CP027143	Enterobacter hormaechei subsp. hoffmannii strain AR_0365 plasmid unnamed3	13679-13705	6	0.778
NC_015501_1	1.1|306579|27|NC_015501|CRISPRCasFinder	306579-306605	27	NZ_CP019010	Escherichia coli strain Ecol_AZ161 plasmid pECAZ161_KPC, complete sequence	6343-6369	6	0.778
NC_015501_1	1.1|306579|27|NC_015501|CRISPRCasFinder	306579-306605	27	NZ_CP018436	Klebsiella pneumoniae strain MNCRE53 plasmid pMNCRE53_3, complete sequence	36437-36463	6	0.778
NC_015501_1	1.1|306579|27|NC_015501|CRISPRCasFinder	306579-306605	27	NZ_CP012686	Serratia marcescens strain SmUNAM836 plasmid pSmUNAM836, complete sequence	3016-3042	6	0.778
NC_015501_1	1.1|306579|27|NC_015501|CRISPRCasFinder	306579-306605	27	NZ_CP018426	Klebsiella pneumoniae strain MNCRE69 plasmid pMNCRE69_3, complete sequence	36437-36463	6	0.778
NC_015501_1	1.1|306579|27|NC_015501|CRISPRCasFinder	306579-306605	27	NZ_CP010387	Enterobacter hormaechei subsp. xiangfangensis strain 34399 plasmid p34399-43.500kb, complete sequence	35033-35059	6	0.778
NC_015501_1	1.1|306579|27|NC_015501|CRISPRCasFinder	306579-306605	27	NZ_CP012163	Enterobacter roggenkampii strain 35734 plasmid p35734-109.753kb, complete sequence	109615-109641	6	0.778
NC_015501_1	1.1|306579|27|NC_015501|CRISPRCasFinder	306579-306605	27	NZ_CP036448	Klebsiella pneumoniae strain KPNIH45 plasmid pKPC-e4b7, complete sequence	23016-23042	6	0.778
NC_015501_1	1.1|306579|27|NC_015501|CRISPRCasFinder	306579-306605	27	NZ_CP021716	Klebsiella pneumoniae strain AR_0129 plasmid tig00000003, complete sequence	26221-26247	6	0.778
NC_015501_1	1.1|306579|27|NC_015501|CRISPRCasFinder	306579-306605	27	NZ_CP018432	Klebsiella pneumoniae strain MNCRE78 plasmid pMNCRE78_3, complete sequence	36436-36462	6	0.778
NC_015501_1	1.1|306579|27|NC_015501|CRISPRCasFinder	306579-306605	27	NZ_MK036884	Leclercia adecarboxylata strain 16005813 plasmid p16005813B, complete sequence	144-170	6	0.778
NC_015501_5	5.19|1153097|33|NC_015501|PILER-CR,CRISPRCasFinder,CRT	1153097-1153129	33	MK416015	Klebsiella phage ST16-OXA48phi5.4, complete genome	9938-9970	8	0.758
NC_015501_5	5.20|1153163|35|NC_015501|PILER-CR,CRISPRCasFinder,CRT	1153163-1153197	35	KF620435	Shigella phage pSb-1, complete genome	39637-39671	9	0.743

1. spacer 1.1|306579|27|NC_015501|CRISPRCasFinder matches to NZ_KX348146 (Klebsiella pneumoniae strain Kp46 plasmid pKPC_Kp46, complete sequence) position: , mismatch: 6, identity: 0.778

tttcgctatacgtctcgcttggacaca	CRISPR spacer
caacgcgatacgtcgcgcttggacacc	Protospacer
.  *** ******* *********** 

2. spacer 1.1|306579|27|NC_015501|CRISPRCasFinder matches to NZ_CP036437 (Citrobacter sp. ABFQG plasmid pKPC-e4b7, complete sequence) position: , mismatch: 6, identity: 0.778

tttcgctatacgtctcgcttggacaca	CRISPR spacer
caacgcgatacgtcgcgcttggacacc	Protospacer
.  *** ******* *********** 

3. spacer 1.1|306579|27|NC_015501|CRISPRCasFinder matches to NZ_CP036440 (Klebsiella pneumoniae strain ABFQB plasmid pKPC-e4b7, complete sequence) position: , mismatch: 6, identity: 0.778

tttcgctatacgtctcgcttggacaca	CRISPR spacer
caacgcgatacgtcgcgcttggacacc	Protospacer
.  *** ******* *********** 

4. spacer 1.1|306579|27|NC_015501|CRISPRCasFinder matches to NZ_CP027143 (Enterobacter hormaechei subsp. hoffmannii strain AR_0365 plasmid unnamed3) position: , mismatch: 6, identity: 0.778

tttcgctatacgtctcgcttggacaca	CRISPR spacer
caacgcgatacgtcgcgcttggacacc	Protospacer
.  *** ******* *********** 

5. spacer 1.1|306579|27|NC_015501|CRISPRCasFinder matches to NZ_CP019010 (Escherichia coli strain Ecol_AZ161 plasmid pECAZ161_KPC, complete sequence) position: , mismatch: 6, identity: 0.778

tttcgctatacgtctcgcttggacaca	CRISPR spacer
caacgcgatacgtcgcgcttggacacc	Protospacer
.  *** ******* *********** 

6. spacer 1.1|306579|27|NC_015501|CRISPRCasFinder matches to NZ_CP018436 (Klebsiella pneumoniae strain MNCRE53 plasmid pMNCRE53_3, complete sequence) position: , mismatch: 6, identity: 0.778

tttcgctatacgtctcgcttggacaca	CRISPR spacer
caacgcgatacgtcgcgcttggacacc	Protospacer
.  *** ******* *********** 

7. spacer 1.1|306579|27|NC_015501|CRISPRCasFinder matches to NZ_CP012686 (Serratia marcescens strain SmUNAM836 plasmid pSmUNAM836, complete sequence) position: , mismatch: 6, identity: 0.778

tttcgctatacgtctcgcttggacaca	CRISPR spacer
caacgcgatacgtcgcgcttggacacc	Protospacer
.  *** ******* *********** 

8. spacer 1.1|306579|27|NC_015501|CRISPRCasFinder matches to NZ_CP018426 (Klebsiella pneumoniae strain MNCRE69 plasmid pMNCRE69_3, complete sequence) position: , mismatch: 6, identity: 0.778

tttcgctatacgtctcgcttggacaca	CRISPR spacer
caacgcgatacgtcgcgcttggacacc	Protospacer
.  *** ******* *********** 

9. spacer 1.1|306579|27|NC_015501|CRISPRCasFinder matches to NZ_CP010387 (Enterobacter hormaechei subsp. xiangfangensis strain 34399 plasmid p34399-43.500kb, complete sequence) position: , mismatch: 6, identity: 0.778

tttcgctatacgtctcgcttggacaca	CRISPR spacer
caacgcgatacgtcgcgcttggacacc	Protospacer
.  *** ******* *********** 

10. spacer 1.1|306579|27|NC_015501|CRISPRCasFinder matches to NZ_CP012163 (Enterobacter roggenkampii strain 35734 plasmid p35734-109.753kb, complete sequence) position: , mismatch: 6, identity: 0.778

tttcgctatacgtctcgcttggacaca	CRISPR spacer
caacgcgatacgtcgcgcttggacacc	Protospacer
.  *** ******* *********** 

11. spacer 1.1|306579|27|NC_015501|CRISPRCasFinder matches to NZ_CP036448 (Klebsiella pneumoniae strain KPNIH45 plasmid pKPC-e4b7, complete sequence) position: , mismatch: 6, identity: 0.778

tttcgctatacgtctcgcttggacaca	CRISPR spacer
caacgcgatacgtcgcgcttggacacc	Protospacer
.  *** ******* *********** 

12. spacer 1.1|306579|27|NC_015501|CRISPRCasFinder matches to NZ_CP021716 (Klebsiella pneumoniae strain AR_0129 plasmid tig00000003, complete sequence) position: , mismatch: 6, identity: 0.778

tttcgctatacgtctcgcttggacaca	CRISPR spacer
caacgcgatacgtcgcgcttggacacc	Protospacer
.  *** ******* *********** 

13. spacer 1.1|306579|27|NC_015501|CRISPRCasFinder matches to NZ_CP018432 (Klebsiella pneumoniae strain MNCRE78 plasmid pMNCRE78_3, complete sequence) position: , mismatch: 6, identity: 0.778

tttcgctatacgtctcgcttggacaca	CRISPR spacer
caacgcgatacgtcgcgcttggacacc	Protospacer
.  *** ******* *********** 

14. spacer 1.1|306579|27|NC_015501|CRISPRCasFinder matches to NZ_MK036884 (Leclercia adecarboxylata strain 16005813 plasmid p16005813B, complete sequence) position: , mismatch: 6, identity: 0.778

tttcgctatacgtctcgcttggacaca	CRISPR spacer
caacgcgatacgtcgcgcttggacacc	Protospacer
.  *** ******* *********** 

15. spacer 5.19|1153097|33|NC_015501|PILER-CR,CRISPRCasFinder,CRT matches to MK416015 (Klebsiella phage ST16-OXA48phi5.4, complete genome) position: , mismatch: 8, identity: 0.758

acaggaccaaaaacagcatcccaataaacagac	CRISPR spacer
ccaggaccaaaaatatcatcccaatagagaacg	Protospacer
 ************.* **********.* *.  

16. spacer 5.20|1153163|35|NC_015501|PILER-CR,CRISPRCasFinder,CRT matches to KF620435 (Shigella phage pSb-1, complete genome) position: , mismatch: 9, identity: 0.743

atgtaattaacgtactttccaccaa----cacggagtaa	CRISPR spacer
atgttattaacgtacttttcaccaaggttcatagg----	Protospacer
**** *************.******    **..*.    

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage
NC_015501.1|WP_013760818.1|1975943_1976360_-|PcfK-like-family-protein	1975943_1976360_-	138 aa aa	40	NA	NA	No	NA

Protein sequences of NC_015501.1|WP_013760818.1|1975943_1976360_-|PcfK-like-family-protein

>NC_015501.1|WP_013760818.1|1975943_1976360_-|PcfK-like-family-protein
MKGTEQFTRTIAEYLNGRAMTDPLFAPNLQKPHKNIEECILYILSEVQRSGCNGFADEEIYSMAVHYYDEDDIEVDKVSGCNVVVNHVVELSEEEKKQARQEAIKQYPQLTKRAKAQQSNKQKQSPFRRHSLTYETKN

gnl|BL_ORD_ID|40 information

• hit_Aca_id: gnl|BL_ORD_ID|40
• identity: 0.5447154471544715
• query_coverage: 0.8985507246376812
• hit_coverage: 0.8723404255319149