CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_015576	Mycolicibacter sinensis, complete sequence	10 crisprs	csa3,cas3,DinG,DEDDh,WYL,csb1gr7	3	5	2	0

1. NC_015576

CRISPR-Cas detection and classification

Crispr_ID: NC_015576_2

• CRISPR_ID: NC_015576_2
• CRISPR_location: 69634-69784
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NC_015576_2

Consensus_repeat	Method
TGGGCGTGCTGGTGCCGCCGGGTGT	CRISPRCasFinder

spacers of NC_015576_2

>2.1|69659|23|NC_015576|CRISPRCasFinder
GGTTCCGCTGGTGCCTGCTGTGG
>2.2|69707|53|NC_015576|CRISPRCasFinder
GCTGGCGCTGTTGCCGCTTCCCGCTGCGCCGCCGTCGGTGCCGGTACCAATAC

CRISPR arrays and Neighbor proteins around NC_015576_2

CRISPR arrays

The CRISPR arrays of NC_015576_2

>merge|NC_015576|2|69634-69784|CRISPRCasFinder
TGGGCGTGCTGGTGCCGCCGGGTGTGGTTCCGCTGGTGCCTGCTGTGGTGGGCGTGCTGGTGCCGCCGGGTGTGCTGGCGCTGTTGCCGCTTCCCGCTGCGCCGCCGTCGGTGCCGGTACCAATACTGGGCGTGCTGGTGCCGCCGGGTGT

>NC_015576|2|2|69634-69784|CRISPRCasFinder
TGGGCGTGCTGGTGCCGCCGGGTGT	GGTTCCGCTGGTGCCTGCTGTGG
TGGGCGTGCTGGTGCCGCCGGGTGT	GCTGGCGCTGTTGCCGCTTCCCGCTGCGCCGCCGTCGGTGCCGGTACCAATAC
TGGGCGTGCTGGTGCCGCCGGGTGT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015576.1|WP_013826999.1|56796_57990_-|PPE-family-protein	unknown	unknown	gnl|CDD|366325
NC_015576.1|WP_041316642.1|66989_67952_-|hypothetical-protein	unknown	unknown	gnl|CDD|312941
NC_015576.1|WP_085975742.1|67948_68647_-|DUF5631-domain-containing-protein	unknown	unknown	gnl|CDD|376071
NC_015576.1|WP_013827004.1|65393_65759_+|hypothetical-protein	unknown	unknown	unknown
NC_015576.1|WP_013827006.1|66387_66909_+|hypothetical-protein	unknown	unknown	unknown
NC_015576.1|WP_013827005.1|65905_66391_+|hypothetical-protein	unknown	unknown	unknown
NC_015576.1|WP_013827011.1|73470_73824_-|VOC-family-protein	unknown	unknown	gnl|CDD|319925
NC_015576.1|WP_013827009.1|71151_71637_-|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl|CDD|379639
NC_015576.1|WP_013827012.1|73895_74024_-|membrane-dipeptidase	unknown	unknown	gnl|CDD|366534
NC_015576.1|WP_081465615.1|70490_70967_-|hypothetical-protein	unknown	unknown	unknown
NC_015576.1|WP_013827016.1|77485_78946_-|alkaline-phosphatase-family-protein	unknown	unknown	gnl|CDD|293742
NC_015576.1|WP_041316640.1|57993_58296_-|PE-family-protein	unknown	unknown	gnl|CDD|376422
NC_015576.1|WP_013827015.1|76018_77479_-|alkaline-phosphatase-family-protein	unknown	unknown	gnl|CDD|293742
NC_015576.1|WP_013827014.1|74841_75960_-|nitronate-monooxygenase	unknown	unknown	gnl|CDD|240081
NC_015576.1|WP_013827017.1|79108_80158_-|DUF4185-domain-containing-protein	unknown	unknown	gnl|CDD|379383
NC_015576.1|WP_013827013.1|74226_74838_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|379228
NC_015576.1|WP_158019414.1|64230_65301_+|DUF4226-domain-containing-protein	unknown	unknown	gnl|CDD|371237
NC_015576.1|WP_013827001.1|58400_62612_-|type-VII-secretion-protein-EccC	unknown	unknown	gnl|CDD|274858
NC_015576.1|WP_041316649.1|71682_73359_-|sensor-domain-containing-protein	unknown	unknown	gnl|CDD|270916
NC_015576.1|WP_013827002.1|62616_64116_-|type-VII-secretion-protein-EccB	unknown	unknown	gnl|CDD|368288

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015576.1|WP_013826999.1|56796_57990_-|PPE-family-protein	gnl|CDD|366325	pfam00823, PPE, PPE family. This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	6.29759e-17
NC_015576.1|WP_041316642.1|66989_67952_-|hypothetical-protein	gnl|CDD|312941	pfam09606, Med15, ARC105 or Med15 subunit of Mediator complex non-fungal. The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.	0.00243716
NC_015576.1|WP_085975742.1|67948_68647_-|DUF5631-domain-containing-protein	gnl|CDD|376071	pfam18645, DUF5631, Family of unknown function (DUF5631). This is an alpha helical domain found at the C-terminal region of the hypothetical protein Rv3899c from Mycobacterium tuberculosis which is conserved across mycobacteria.	1.45232e-39
NC_015576.1|WP_041316649.1|71682_73359_-|sensor-domain-containing-protein	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	6.85281e-103
NC_015576.1|WP_013827011.1|73470_73824_-|VOC-family-protein	gnl|CDD|319925	cd07264, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	2.18951e-11
NC_015576.1|WP_013827009.1|71151_71637_-|nuclear-transport-factor-2-family-protein	gnl|CDD|379639	pfam14534, DUF4440, Domain of unknown function (DUF4440).	0.000287486
NC_015576.1|WP_013827012.1|73895_74024_-|membrane-dipeptidase	gnl|CDD|366534	pfam01244, Peptidase_M19, Membrane dipeptidase (Peptidase family M19).	6.20465e-06
NC_015576.1|WP_013827016.1|77485_78946_-|alkaline-phosphatase-family-protein	gnl|CDD|293742	cd16018, Enpp, Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin. Ecto-nucleotide pyrophosphatases/phosphodiesterases (ENPPs) hydrolyze 5'-phosphodiester bonds in nucleotides and their derivatives, resulting in the release of 5'-nucleotide monophosphates. ENPPs have multiple physiological roles, including nucleotide recycling, modulation of purinergic receptor signaling, regulation of extracellular pyrophosphate levels, stimulation of cell motility, and possible roles in regulation of insulin receptor (IR) signaling and activity of ecto-kinases. The eukaryotic ENPP family contains at least five members that have different tissue distribution and physiological roles.	4.47302e-13
NC_015576.1|WP_041316640.1|57993_58296_-|PE-family-protein	gnl|CDD|376422	pfam00934, PE, PE family. This family named after a PE motif near to the amino terminus of the domain. The PE family of proteins all contain an amino-terminal region of about 110 amino acids. The carboxyl terminus of this family are variable and fall into several classes. The largest class of PE proteins is the highly repetitive PGRS class which have a high glycine content. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	5.36519e-05
NC_015576.1|WP_013827015.1|76018_77479_-|alkaline-phosphatase-family-protein	gnl|CDD|293742	cd16018, Enpp, Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin. Ecto-nucleotide pyrophosphatases/phosphodiesterases (ENPPs) hydrolyze 5'-phosphodiester bonds in nucleotides and their derivatives, resulting in the release of 5'-nucleotide monophosphates. ENPPs have multiple physiological roles, including nucleotide recycling, modulation of purinergic receptor signaling, regulation of extracellular pyrophosphate levels, stimulation of cell motility, and possible roles in regulation of insulin receptor (IR) signaling and activity of ecto-kinases. The eukaryotic ENPP family contains at least five members that have different tissue distribution and physiological roles.	1.48709e-14
NC_015576.1|WP_013827014.1|74841_75960_-|nitronate-monooxygenase	gnl|CDD|240081	cd04730, NPD_like, 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase family that reduce a range of alternative electron acceptors. Most use FAD/FMN as a cofactor and NAD(P)H as electron donor. Some contain 4Fe-4S cluster to transfer electron from FAD to FMN.	3.60901e-57
NC_015576.1|WP_013827017.1|79108_80158_-|DUF4185-domain-containing-protein	gnl|CDD|379383	pfam13810, DUF4185, Domain of unknown function (DUF4185).	2.68955e-72
NC_015576.1|WP_013827013.1|74226_74838_+|GNAT-family-N-acetyltransferase	gnl|CDD|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	2.77228e-06
NC_015576.1|WP_158019414.1|64230_65301_+|DUF4226-domain-containing-protein	gnl|CDD|371237	pfam10774, DUF4226, Domain of unknown function (DUF4226). This family of mycobacterial proteins are uncharacterized.	1.17429e-39
NC_015576.1|WP_013827001.1|58400_62612_-|type-VII-secretion-protein-EccC	gnl|CDD|274858	TIGR03924, T7SS_EccC_a, type VII secretion protein EccCa. This model represents the N-terminal domain or EccCa subunit of the type VII secretion protein EccC as found in the Actinobacteria. Type VII secretion is defined more broadly as including secretion systems for ESAT-6-like proteins in the Firmicutes as well as in the Actinobacteria, but this family does not show close homologs in the Firmicutes. [Protein fate, Protein and peptide secretion and trafficking].	0
NC_015576.1|WP_013827002.1|62616_64116_-|type-VII-secretion-protein-EccB	gnl|CDD|368288	pfam05108, T7SS_ESX1_EccB, Type VII secretion system ESX-1, transport TM domain B. EccB is a family of largely Gram-positive bacterial transmembrane componenets of the type VII secretion system characterized in Mycobacterium tuberculosis, systems ESX1-5. Translocation of virulent peptides through the membranes is thought to be mediated via a complex that includes EccB, EccC, EccD, EccE, and MycP. EccB, EccC, EccD, and EccE form a stable complex in the mycobacterial cell envelope.	1.06298e-171

Protein sequences

>NC_015576.1|WP_085975742.1|67948_68647_-|DUF5631-domain-containing-protein
MAAGATAGAGAGTAAKRLAEHQDLQRKVDAVARQAPNLAWAAGLRDDETTTVVVTDLAGGWIPPTVTLPPGVTLLEPAHRRSGTSAVDLLGAVIAAATHEPNTYITEADPHDPPVPGTGERARYGQHVDELGPTLIDVAGSSTRLPRIVQTVAQAMARRSGVADNEVDLFRQVVADTAARVLSAYPEHAPRDVADWMLLAAVDALIDGSEELARYHLAWHETVAVRHGGVLR
>NC_015576.1|WP_041316642.1|66989_67952_-|hypothetical-protein
MTGDKIEVNPMDYWDILRGLPPEPIPTGPAHLGGQSPVDLTAAAFGFTTNTDLPETNTQIATDTTERKAGASDAARKFATNEADAVSKFEGVAGEGDAAMAQQGSQEAMGGAMQGMTGAMQGITGALSGALGAASRLPQGLMQAGQGALSPLMGAAQSLAKGGLGGTTLASDISPDPGLGGGDFGSGGAGGGGLGMGTTPASNLGPPPVPGTSTPTTPASSLANTGVAGPSGGAPATGGAGGGGMMPMMPGAAGAGGKGGKDDKAGEKRIAAPGVPNGQPVKGRTTAPPNVPVTKSVAKDAGQTGLTPLKRIVDKDDSSK
>NC_015576.1|WP_013827006.1|66387_66909_+|hypothetical-protein
MIRRLGALGTLVVALLAGCPAKAPWAPSLPPAFGARVTNGKLQIWTGSPCVGVTRIALYFGPGTAELTLTSPEGVDIERLTLGGPYPVGMTESQPLPADFEWRNEKTMGFSTYGGSSRWGTSTDLTEVIEGSGTHPEDTFWFQDVGWLNPAQVAAQDGRTFLATCTADPAKKS
>NC_015576.1|WP_013827005.1|65905_66391_+|hypothetical-protein
MPEVLGLFADAARAREAENLWSYGAAWASEVSGGSVVTAPNGMLMGLGGKVQDTLSCQGGTTYGDVFMVNIDRSADPADQLRKIVHSGVAWGPDSNGNPVQNVQLDLDRLLHHEERHSQQYAKLGPVGMGIAYGEEAIRTRIFGGDNWFEKNAGLHDGGYE
>NC_015576.1|WP_013827004.1|65393_65759_+|hypothetical-protein
MDIDYNDQRLNEGLANLLHQGKSGRLSDFTSWPWDEVHLFHEYTEREFIEKTVGAPVIRSNFFESKASLLVFEDHGKPVKAVGIAADYLRGQDHRVSWPADVMLQPCCGGYLQLTLPSAGA
>NC_015576.1|WP_158019414.1|64230_65301_+|DUF4226-domain-containing-protein
MPEVMGVFANAARAREAELTRRLATSVELDRSFQEILRGAHQFNAQSRQRLDALEAEIRQAAAAWPALNTPAGARQFQAYLTGKTREIHKVVADAAADSQQRAAQVQALTGRYPLRGDRTIQSVDFPQQGPPPVDPLEQILKTYQVSEDPDGELDWEPPWPLSLATDPVHVTAGEARMLEDLSPFALRDLNQIKEAAATEAKVRFPPQNGPNDTADNHTDAFRHAYWNALMTQRFGENWTRDFATAHERLPNNHATAEAMDLYNNELGREIATANPRATPAQLADLVQQAVDSGDTVVVAPGGEKLAWSNSIAWGEAGTTTNATLPGQTPTPTGAGPGGVYDPGQPGGYGTSAGGY
>NC_015576.1|WP_013827002.1|62616_64116_-|type-VII-secretion-protein-EccB
MPLSLSNRDQNSGHLFYNRRLRAATTKFSVRMKHDDRKQTAAIVLSVVLIFIGMGWMLLLNVLRPAGIVRTSAIVGDRDSGAIYARINGRLYPALNMTSARLAVGNAELPTWVKPPEIAKYPTGPMIGIPGAPASLIANTGAPSAWAVCDTAGSPRRVEPPVVTAIAGTLSPAGRAAPLASDAAVLTRFQDATYVIWGGKRSQVDPADRAITLSLGIDPGTTVPVEMSRALFDALPSTEPLRVPAIPLAGTPSQWVPGSQVGTVLETRTAGGGSQFYVLLPDGVQKITSFVADLIRSANSFGSVAPLVISPDKLVNIPEVGTLPVEYYPNSRLKFVDTAADPTTCVSWEKAPTDRQARITVFNGRGLPVSPAMDNRIVRLVRDDRTPGSVVANQVLVLPGATNLVTSTSALLESDSRETLFWVSPNGVRFGIAAEDETLRGLGLDPASAQQAPWPLLRTFAAGPELSRHAALLARDTLPSTGEVMPVAPNNQQAIPGGH
>NC_015576.1|WP_013827001.1|58400_62612_-|type-VII-secretion-protein-EccC
MSKRAFVPVRLQVPEPKPVRVAPRAPDALPEREPRNLWVMIGLPALVVALIGTIVMLYVSGVRSLGSGMFPMMGMAGLGMLMFSGRFGRARKISWGEQEKNRRSYLRSLDGERDEIQKAVCAQRSAQETVHSNPQGLGAVIGGPQMWERRRSDADFLDVRVGVGVQHAPDSVLSVQWPEIPVDEELEPVTGQALRDFILEQRKIRDIAKVVNLRSRPGFSFVGDDLDKVRSLLRSVLSALAVFHNPLDVKLMVVTRHPELWSWMVWLPHNQHDELFDACGWRRLVFTSPTELESTLGADLHMKGKRGAWRPPSAPSPTTMGSALESGGDGLDLGPHWVIVDDNTGSPEAWESVVGRVGKEGITVLRVASRLGTGVGFARDEIFEVVDHPARHNRTDGPASTHRRNGRGADPSLPPMLRAGGKFFAHADQLSVPRAYRYARAMARWTPTASVDVTDSGSGALELLRALGIDDARELNVDRLWAERRSRGDERWAEIPVGAKPNGELQNIVLRAKDFGGFGFHSVVIGTSGSGKSEFFLSLVYGIALTHSPETFNVIFVDMKFESAAQDILGIPHVSAALSNLGKDDRHLAERMRRAIDGEIARRYRLFNSVGARDANDYEEIRLAGRDLEPVPILLVVIDEYLELFANHGKWIDLIIHIGQEGRGANVFFMLGGQRLDLSSLQKVKSNIAFRVALRAESGDDSREVIGSDAAYHLPSKENGFGLLKVGPRDLDPFRCFYLSAPFIVPKRKASTAKTLDMTLTKPRLYTWQYQPLDEADAQALQDMSATDAEPDEYLLHADGFKKKKIVDVLRESLISADRKAPHLPWLPPLEVSESADSLVALYRGKPWDVDYGRNPGLVWPLAVKDIPEDAQQLVHCVDVLRSNVMVVGAKSRGKTTALMTLMCSAALMYTPARLTFFCVGGATLGYAETLPHVADIVSPADREGVERTVATMAALISARQDTFRRDKIDINEFRERRFGAGSDGLGGTDPGDPYGDVFLVIDDFSDLYAADTVLGDRIIALSGVGPEYGVHLMTSASGWIHGQRQTLLQNSDVRIQLRLQNPGENEMGTASLDARDAAKRTVNRPGFGLTESLHEMLIGMPELTARDGSRIGTRDLGTRVAEVAGVTKHATLKRLPPAVALSEVLAYDVAQRPPAQTAPSIAFMIGEQHDLLPVPLELGEHPGMMILGRALCGKSATLAAIGEAVMARFSPEQAQITIIDPKTGPLRDLQGPGYVNAYAYDQDEIDEVLTTLAQQVLLPRLPAKGLSQEELRALKPWEGPRHFILVDDVQDLRPAQIHPAKPPVGAALWKLMERGRQIGLHVFATRNSSNFGQLEMDPWVKTQRSAKAPTLFMDNDPQNKVSRTVRAQALPAGRGLLVLDDSRVEGVLVGVPSSMIHNFEQQ
>NC_015576.1|WP_041316640.1|57993_58296_-|PE-family-protein
MFSVEPEAVLASSGVEAAITAETAAAASSASPALLGVLPMGNDPDSIAFQAALLASGSEYLGIVAEHSAQRGLYSGAQSTAAGVYSATEALRAATAALSG
>NC_015576.1|WP_013826999.1|56796_57990_-|PPE-family-protein
MADPGWAARPPEVNDTLIKSGMGVATMLANGTAWTTLGAAHHASGIASAVNTALTSVGWIGAGSASSALNATLLNVALHGLAGWVDMKAPIVAAAVEAYQLAYGSMRTTQECEANRIETATDYGINPIVLGALWPRITSLEYEYFGMFWPNNAAVGASYGATLTALTSSLTVPAPVAGMGASPAAPAAAASAVGDAAAQTAAGGAMRAAYTGTSAASNTAGQGASAAQGMGGEMSSLLGPVQSIGSSLMQAPQSLMQMPQSMMSPMQSMMGMFMNPSMFGGALNAAGAGGAPATAMLANATATPGGGVGGGGVGGAGAPVSAFTRPVSAFESGGGRPVGLRPSGALGSVESQQRVTTTSGAGMGGMPIGHAAGAAGRGQSGRSSDRANTVRVVDDRL
>NC_015576.1|WP_081465615.1|70490_70967_-|hypothetical-protein
MTPAPWPAPATAQPGHRSALVLATLAALLAVGALVVAVLALNKSTGTATYTTEQKSAAKNQLCERYKLAAHAMHIETSTPDNATFARISATNGALIIDVAAADPALDARYRDAAHNLTISYLDLTALGTAGMSDATSYQQAVDTLNARDHVMQELCGE
>NC_015576.1|WP_013827009.1|71151_71637_-|nuclear-transport-factor-2-family-protein
MIASRRWYAGIGSLLVTSVLVTSCSSSLTAGTPVTEHSASPAPSAVAPPSPPAPEPPPPPSDDDQIRQTVQAFQDAYNTQNWDAYKEQMCPAMRDQFTDGPVMDLLKKTRADGGLTRATVSAVDIDGDVATVTLDSQNEASGNLAPTLRLERGDGWKICVR
>NC_015576.1|WP_041316649.1|71682_73359_-|sensor-domain-containing-protein
MFTAGQVVDGYRIEQVLGTGGMGTVYLAANPTLPRREALKILSAELSRNSDFRARFIREAEVAAGLDHPHIVSVYNRGQTADGQLWIAMQFVDGTDADAAQRSGTMTPQRAVHIVSDVAKALDYAHARNVIHRDVKPANFLLTGTPGADERALLADFGIARALDDVGLTATGSVLATIAYAAPEVLSGTHLDGRADIYSLGCTLFSLLTGYAPFSSANGMAAVMMAHLHQPPPRPTDFVPSLPPALDVVIATAMAKDPAARFPSASALAQAARAALSNQLPAGLHYATPQSTPVRQPERPSSPRRRTWVLAGGAAAVLMVAGSIAAATMAGRERPPEPTTVVTSNTPAHSTIPLAGAEPGAPQGAASDDVQPEALRPILLPAGQLRSTEHELVLEEDISTLLDDAAAVSAPDCVGTWAPVQERAMGGHGQTGVAVQVLRAMNRKATEEGVVQAVVSYPTHMAAVQSLQQQQRQWQGCAGQSITVAAPGSGPQTWDFDQSQTFAGTVTSAARLRDGTAVCQHGINVRGNVLIDIRQCLPRGGNDVSALVNATGDRVPSR
>NC_015576.1|WP_013827011.1|73470_73824_-|VOC-family-protein
MSDHDIRMIVLSTDDLDESIKFYSETLGMPLKFRDGTHFAALDGGSVTLALATAVDHPIHGQVVVGIKTDDVDGAAKAIEASGGGIVKGPYDDAHERRAVVYDNKGNGLVFYKPLAR
>NC_015576.1|WP_013827012.1|73895_74024_-|membrane-dipeptidase
MPPETWLGLREHLAARGWADADIAAVLGGNFHRVAREAWRAV
>NC_015576.1|WP_013827013.1|74226_74838_+|GNAT-family-N-acetyltransferase
MAIDVRPANKPDIAPLAHTLGRAFYDDPVSMWMLPDDASRTAQLTAFFGTSTRVHHLSGGGVEVAYDGATVGAAALWDPPDRWKQSTWSQLRMVPSLIRSFGFRLSQGRALSDLLDANHPEEPHWYLAVIGSDPSVRGRGFGQAVMQPRLERCDAESCPAYLESSKEENVPYYERFGFRVIGEISLPNGGPTLWKMWREPQNP
>NC_015576.1|WP_013827014.1|74841_75960_-|nitronate-monooxygenase
MKTPICEQYGIDFPLFAFSHCRDVVAAVTNAGGFGVLGGAAYTPEQLDQELSWIDEQVKGKPYGIDIIVPAKFEGKGESLSGRQLSDRIPAEYQTFIANLLAEHDIEPDDKPRLGPAMLAGSAGEQLLEVAVAHPIRLMANALGVPPDYMIKSGQDHGIPVAALVGAKEHALKQVTHGVDLIVAQGTEAGGHCGEVSTLVLVPEVIDAIDDAVPVLAAGGIVTGRQMAACVALGAAGAWTGSVWLTTEEAETAPHTKQKMLAATSRDTIRSTGRTGKPARQLVSEWTDAWRPNEAGHPTLPLPLQSMLAEPALRRVDALAAAGHPGAQALATYFVGQGVGLMNKVKPAREVVFEFAQDYLAAAERLGDSVGE
>NC_015576.1|WP_013827015.1|76018_77479_-|alkaline-phosphatase-family-protein
MTTLKQILCGTAVAGLVAGAGAAVEPQVGLSTVTADWLLAAEHVLLLGTDGTNLDKILEYAYNDDSGFKMLMDRGVTAATTIAGHQTMSTPSWSTILTGVWDDKHGVVSNVYRPEPYTTWPSVFNLIEYHKPEVDTTVISGRGLFTEMASTGGYPADNIIGITGGSTSAEMDALVTDETIARILATTENPDTSTFMFSYQSQVDHAGHSYSGGSEEYKEAVINVGANFKQILDAVAQAEAATGDRWTIIAVTDHGHQQTVTLPGFSLGHGFQTPNETSSFIMFSLAGNDDQAGGQNLSYQTVDITPTILQAFGIQMRSDFDGVPMQTDPEILNGFIMPVDLKQSLTDAINSYGYPDIGTNIMLSIRALAGGAGFFIGSYLLPPISNFLQTIIDQDIFLISGLAQGAQWLLNTVGGVVADVATDLGRAVAYLTGAGVIPPEDAPLPLPGSAEFSDSVAALLAGHTVAVPDLVDADLPLLVDIDALVG
>NC_015576.1|WP_013827016.1|77485_78946_-|alkaline-phosphatase-family-protein
MTTIKQFLCGATVAGMVAATGAAVGAPAGLSAVTADWLLAAEHVLLIGLDGVNLSKVLEYAYDDDSGFKTAMDQGITGAASLTNHTTLSGPSWSTILTGVWDDKHGVFNNLFRPEPYNQWPTVFNLIEYNKPEVDTTIISNWEYLNQLAGAGGYSVDNNIFVPAGDSPADSDALVTALTIAQILGTEDNPDDISSFLFSYQSQADHAGHSFAGGSDEYMQSIINLGANLQQILAAIAHVQAITGDDWSVILTTDHGHQQTVTLPGLSIGHGFQSPNETSTFVIFDQAGDDANDGSQSLGYSTVDITPTILSLFGIPLRSDFDGVSLADDPTVLNGHVTPVDLEQALLAAIAMYGYPNIGNDITLAIRTVIGSVPYFLDKFVTEIDTFLQSIVDQDIFLISGLAEVAQQINEFFGGLTVNVTNTVAHGFAYLLGSGVIAPTDAPLPLPGAAEFTGSLESLLAGDTFTAPDIGDLDLSLLLDVDALLG
>NC_015576.1|WP_013827017.1|79108_80158_-|DUF4185-domain-containing-protein
MSLAARHVPGKLADVTGPGITDQWGVTCADLGASVLAPDGSLVSVFGDTFAGDKVGRGDWRSPVILIGTGDAGHRIRYRRAGGPDGDYARQLWHYRHREPVSRLDRSSISTVIPSDLLRVDQLLYLHAIVNRGFGNVAWTEIWQSADSGTTWHNIGTRFPARRHRGHAQCWSWDYDPDDGWVYVVSTGFQRNKGVILRRVRPADIGNPAKYSGWGYRGGRRAWGRTPVPITPPGETWGELSLRRLAAGTWVLGGFVSSRYALGYRVLDSPASELASVPLQLPVIGCSWDREDHAGSRVAQLYGGYVLPGSRVDRTGGVGLLVSQWNTAAGWPYRVMQFRATLASGEEIR

Crispr_ID: NC_015576_1

• CRISPR_ID: NC_015576_1
• CRISPR_location: 69319-69527
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 3 spacers

Consensus repeat of NC_015576_1

Consensus_repeat	Method
TGGGCGTGCTGGTGCCGCCGGGTGT	CRISPRCasFinder

spacers of NC_015576_1

>1.1|69344|26|NC_015576|CRISPRCasFinder
TACGCCAGCGGGAAGCGGGTTTTTGC
>1.2|69395|41|NC_015576|CRISPRCasFinder
TGTGGTTCCCACTGGGGCGGGGCTGCCTGGGGGCGGGGCGC
>1.3|69461|41|NC_015576|CRISPRCasFinder
TGTGGTTCCCGCTGGGGCGGGGCTGCCTGGGGGCGGGGCGC

CRISPR arrays and Neighbor proteins around NC_015576_1

CRISPR arrays

The CRISPR arrays of NC_015576_1

>merge|NC_015576|1|69319-69527|CRISPRCasFinder
AGCCCGTGTTGCTTCCGGCGGTTGTTACGCCAGCGGGAAGCGGGTTTTTGCTGGCCACTGTGGTGCCGCCCGGAGTTGTGGTTCCCACTGGGGCGGGGCTGCCTGGGGGCGGGGCGCTGCCTGTTGTGGTGCCGCCCGGAGTTGTGGTTCCCGCTGGGGCGGGGCTGCCTGGGGGCGGGGCGCTGCCTGTTGTGGTGCCGCCCGCGGTT

>NC_015576|1|1|69319-69527|CRISPRCasFinder
AGCCCGTGTTGCTTCCGGCGGTTGT	TACGCCAGCGGGAAGCGGGTTTTTGC
TGGCCACTGTGGTGCCGCCCGGAGT	TGTGGTTCCCACTGGGGCGGGGCTGCCTGGGGGCGGGGCGC
TGCCTGTTGTGGTGCCGCCCGGAGT	TGTGGTTCCCGCTGGGGCGGGGCTGCCTGGGGGCGGGGCGC
TGCCTGTTGTGGTGCCGCCCGCGGTT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015576.1|WP_013826999.1|56796_57990_-|PPE-family-protein	unknown	unknown	gnl|CDD|366325
NC_015576.1|WP_041316642.1|66989_67952_-|hypothetical-protein	unknown	unknown	gnl|CDD|312941
NC_015576.1|WP_085975742.1|67948_68647_-|DUF5631-domain-containing-protein	unknown	unknown	gnl|CDD|376071
NC_015576.1|WP_013827004.1|65393_65759_+|hypothetical-protein	unknown	unknown	unknown
NC_015576.1|WP_013827006.1|66387_66909_+|hypothetical-protein	unknown	unknown	unknown
NC_015576.1|WP_013827005.1|65905_66391_+|hypothetical-protein	unknown	unknown	unknown
NC_015576.1|WP_013827011.1|73470_73824_-|VOC-family-protein	unknown	unknown	gnl|CDD|319925
NC_015576.1|WP_013827009.1|71151_71637_-|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl|CDD|379639
NC_015576.1|WP_013827012.1|73895_74024_-|membrane-dipeptidase	unknown	unknown	gnl|CDD|366534
NC_015576.1|WP_158019415.1|69620_69968_+|hypothetical-protein	unknown	unknown	gnl|CDD|237864
NC_015576.1|WP_081465615.1|70490_70967_-|hypothetical-protein	unknown	unknown	unknown
NC_015576.1|WP_013827016.1|77485_78946_-|alkaline-phosphatase-family-protein	unknown	unknown	gnl|CDD|293742
NC_015576.1|WP_041316640.1|57993_58296_-|PE-family-protein	unknown	unknown	gnl|CDD|376422
NC_015576.1|WP_013827015.1|76018_77479_-|alkaline-phosphatase-family-protein	unknown	unknown	gnl|CDD|293742
NC_015576.1|WP_013827014.1|74841_75960_-|nitronate-monooxygenase	unknown	unknown	gnl|CDD|240081
NC_015576.1|WP_013827013.1|74226_74838_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|379228
NC_015576.1|WP_158019414.1|64230_65301_+|DUF4226-domain-containing-protein	unknown	unknown	gnl|CDD|371237
NC_015576.1|WP_013827001.1|58400_62612_-|type-VII-secretion-protein-EccC	unknown	unknown	gnl|CDD|274858
NC_015576.1|WP_041316649.1|71682_73359_-|sensor-domain-containing-protein	unknown	unknown	gnl|CDD|270916
NC_015576.1|WP_013827002.1|62616_64116_-|type-VII-secretion-protein-EccB	unknown	unknown	gnl|CDD|368288

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015576.1|WP_013826999.1|56796_57990_-|PPE-family-protein	gnl|CDD|366325	pfam00823, PPE, PPE family. This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	6.29759e-17
NC_015576.1|WP_041316642.1|66989_67952_-|hypothetical-protein	gnl|CDD|312941	pfam09606, Med15, ARC105 or Med15 subunit of Mediator complex non-fungal. The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.	0.00243716
NC_015576.1|WP_085975742.1|67948_68647_-|DUF5631-domain-containing-protein	gnl|CDD|376071	pfam18645, DUF5631, Family of unknown function (DUF5631). This is an alpha helical domain found at the C-terminal region of the hypothetical protein Rv3899c from Mycobacterium tuberculosis which is conserved across mycobacteria.	1.45232e-39
NC_015576.1|WP_041316649.1|71682_73359_-|sensor-domain-containing-protein	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	6.85281e-103
NC_015576.1|WP_013827011.1|73470_73824_-|VOC-family-protein	gnl|CDD|319925	cd07264, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	2.18951e-11
NC_015576.1|WP_013827009.1|71151_71637_-|nuclear-transport-factor-2-family-protein	gnl|CDD|379639	pfam14534, DUF4440, Domain of unknown function (DUF4440).	0.000287486
NC_015576.1|WP_013827012.1|73895_74024_-|membrane-dipeptidase	gnl|CDD|366534	pfam01244, Peptidase_M19, Membrane dipeptidase (Peptidase family M19).	6.20465e-06
NC_015576.1|WP_158019415.1|69620_69968_+|hypothetical-protein	gnl|CDD|237864	PRK14950, PRK14950, DNA polymerase III subunits gamma and tau; Provisional.	0.00188065
NC_015576.1|WP_013827016.1|77485_78946_-|alkaline-phosphatase-family-protein	gnl|CDD|293742	cd16018, Enpp, Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin. Ecto-nucleotide pyrophosphatases/phosphodiesterases (ENPPs) hydrolyze 5'-phosphodiester bonds in nucleotides and their derivatives, resulting in the release of 5'-nucleotide monophosphates. ENPPs have multiple physiological roles, including nucleotide recycling, modulation of purinergic receptor signaling, regulation of extracellular pyrophosphate levels, stimulation of cell motility, and possible roles in regulation of insulin receptor (IR) signaling and activity of ecto-kinases. The eukaryotic ENPP family contains at least five members that have different tissue distribution and physiological roles.	4.47302e-13
NC_015576.1|WP_041316640.1|57993_58296_-|PE-family-protein	gnl|CDD|376422	pfam00934, PE, PE family. This family named after a PE motif near to the amino terminus of the domain. The PE family of proteins all contain an amino-terminal region of about 110 amino acids. The carboxyl terminus of this family are variable and fall into several classes. The largest class of PE proteins is the highly repetitive PGRS class which have a high glycine content. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	5.36519e-05
NC_015576.1|WP_013827015.1|76018_77479_-|alkaline-phosphatase-family-protein	gnl|CDD|293742	cd16018, Enpp, Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin. Ecto-nucleotide pyrophosphatases/phosphodiesterases (ENPPs) hydrolyze 5'-phosphodiester bonds in nucleotides and their derivatives, resulting in the release of 5'-nucleotide monophosphates. ENPPs have multiple physiological roles, including nucleotide recycling, modulation of purinergic receptor signaling, regulation of extracellular pyrophosphate levels, stimulation of cell motility, and possible roles in regulation of insulin receptor (IR) signaling and activity of ecto-kinases. The eukaryotic ENPP family contains at least five members that have different tissue distribution and physiological roles.	1.48709e-14
NC_015576.1|WP_013827014.1|74841_75960_-|nitronate-monooxygenase	gnl|CDD|240081	cd04730, NPD_like, 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase family that reduce a range of alternative electron acceptors. Most use FAD/FMN as a cofactor and NAD(P)H as electron donor. Some contain 4Fe-4S cluster to transfer electron from FAD to FMN.	3.60901e-57
NC_015576.1|WP_013827013.1|74226_74838_+|GNAT-family-N-acetyltransferase	gnl|CDD|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	2.77228e-06
NC_015576.1|WP_158019414.1|64230_65301_+|DUF4226-domain-containing-protein	gnl|CDD|371237	pfam10774, DUF4226, Domain of unknown function (DUF4226). This family of mycobacterial proteins are uncharacterized.	1.17429e-39
NC_015576.1|WP_013827001.1|58400_62612_-|type-VII-secretion-protein-EccC	gnl|CDD|274858	TIGR03924, T7SS_EccC_a, type VII secretion protein EccCa. This model represents the N-terminal domain or EccCa subunit of the type VII secretion protein EccC as found in the Actinobacteria. Type VII secretion is defined more broadly as including secretion systems for ESAT-6-like proteins in the Firmicutes as well as in the Actinobacteria, but this family does not show close homologs in the Firmicutes. [Protein fate, Protein and peptide secretion and trafficking].	0
NC_015576.1|WP_013827002.1|62616_64116_-|type-VII-secretion-protein-EccB	gnl|CDD|368288	pfam05108, T7SS_ESX1_EccB, Type VII secretion system ESX-1, transport TM domain B. EccB is a family of largely Gram-positive bacterial transmembrane componenets of the type VII secretion system characterized in Mycobacterium tuberculosis, systems ESX1-5. Translocation of virulent peptides through the membranes is thought to be mediated via a complex that includes EccB, EccC, EccD, EccE, and MycP. EccB, EccC, EccD, and EccE form a stable complex in the mycobacterial cell envelope.	1.06298e-171

Protein sequences

>NC_015576.1|WP_085975742.1|67948_68647_-|DUF5631-domain-containing-protein
MAAGATAGAGAGTAAKRLAEHQDLQRKVDAVARQAPNLAWAAGLRDDETTTVVVTDLAGGWIPPTVTLPPGVTLLEPAHRRSGTSAVDLLGAVIAAATHEPNTYITEADPHDPPVPGTGERARYGQHVDELGPTLIDVAGSSTRLPRIVQTVAQAMARRSGVADNEVDLFRQVVADTAARVLSAYPEHAPRDVADWMLLAAVDALIDGSEELARYHLAWHETVAVRHGGVLR
>NC_015576.1|WP_041316642.1|66989_67952_-|hypothetical-protein
MTGDKIEVNPMDYWDILRGLPPEPIPTGPAHLGGQSPVDLTAAAFGFTTNTDLPETNTQIATDTTERKAGASDAARKFATNEADAVSKFEGVAGEGDAAMAQQGSQEAMGGAMQGMTGAMQGITGALSGALGAASRLPQGLMQAGQGALSPLMGAAQSLAKGGLGGTTLASDISPDPGLGGGDFGSGGAGGGGLGMGTTPASNLGPPPVPGTSTPTTPASSLANTGVAGPSGGAPATGGAGGGGMMPMMPGAAGAGGKGGKDDKAGEKRIAAPGVPNGQPVKGRTTAPPNVPVTKSVAKDAGQTGLTPLKRIVDKDDSSK
>NC_015576.1|WP_013827006.1|66387_66909_+|hypothetical-protein
MIRRLGALGTLVVALLAGCPAKAPWAPSLPPAFGARVTNGKLQIWTGSPCVGVTRIALYFGPGTAELTLTSPEGVDIERLTLGGPYPVGMTESQPLPADFEWRNEKTMGFSTYGGSSRWGTSTDLTEVIEGSGTHPEDTFWFQDVGWLNPAQVAAQDGRTFLATCTADPAKKS
>NC_015576.1|WP_013827005.1|65905_66391_+|hypothetical-protein
MPEVLGLFADAARAREAENLWSYGAAWASEVSGGSVVTAPNGMLMGLGGKVQDTLSCQGGTTYGDVFMVNIDRSADPADQLRKIVHSGVAWGPDSNGNPVQNVQLDLDRLLHHEERHSQQYAKLGPVGMGIAYGEEAIRTRIFGGDNWFEKNAGLHDGGYE
>NC_015576.1|WP_013827004.1|65393_65759_+|hypothetical-protein
MDIDYNDQRLNEGLANLLHQGKSGRLSDFTSWPWDEVHLFHEYTEREFIEKTVGAPVIRSNFFESKASLLVFEDHGKPVKAVGIAADYLRGQDHRVSWPADVMLQPCCGGYLQLTLPSAGA
>NC_015576.1|WP_158019414.1|64230_65301_+|DUF4226-domain-containing-protein
MPEVMGVFANAARAREAELTRRLATSVELDRSFQEILRGAHQFNAQSRQRLDALEAEIRQAAAAWPALNTPAGARQFQAYLTGKTREIHKVVADAAADSQQRAAQVQALTGRYPLRGDRTIQSVDFPQQGPPPVDPLEQILKTYQVSEDPDGELDWEPPWPLSLATDPVHVTAGEARMLEDLSPFALRDLNQIKEAAATEAKVRFPPQNGPNDTADNHTDAFRHAYWNALMTQRFGENWTRDFATAHERLPNNHATAEAMDLYNNELGREIATANPRATPAQLADLVQQAVDSGDTVVVAPGGEKLAWSNSIAWGEAGTTTNATLPGQTPTPTGAGPGGVYDPGQPGGYGTSAGGY
>NC_015576.1|WP_013827002.1|62616_64116_-|type-VII-secretion-protein-EccB
MPLSLSNRDQNSGHLFYNRRLRAATTKFSVRMKHDDRKQTAAIVLSVVLIFIGMGWMLLLNVLRPAGIVRTSAIVGDRDSGAIYARINGRLYPALNMTSARLAVGNAELPTWVKPPEIAKYPTGPMIGIPGAPASLIANTGAPSAWAVCDTAGSPRRVEPPVVTAIAGTLSPAGRAAPLASDAAVLTRFQDATYVIWGGKRSQVDPADRAITLSLGIDPGTTVPVEMSRALFDALPSTEPLRVPAIPLAGTPSQWVPGSQVGTVLETRTAGGGSQFYVLLPDGVQKITSFVADLIRSANSFGSVAPLVISPDKLVNIPEVGTLPVEYYPNSRLKFVDTAADPTTCVSWEKAPTDRQARITVFNGRGLPVSPAMDNRIVRLVRDDRTPGSVVANQVLVLPGATNLVTSTSALLESDSRETLFWVSPNGVRFGIAAEDETLRGLGLDPASAQQAPWPLLRTFAAGPELSRHAALLARDTLPSTGEVMPVAPNNQQAIPGGH
>NC_015576.1|WP_013827001.1|58400_62612_-|type-VII-secretion-protein-EccC
MSKRAFVPVRLQVPEPKPVRVAPRAPDALPEREPRNLWVMIGLPALVVALIGTIVMLYVSGVRSLGSGMFPMMGMAGLGMLMFSGRFGRARKISWGEQEKNRRSYLRSLDGERDEIQKAVCAQRSAQETVHSNPQGLGAVIGGPQMWERRRSDADFLDVRVGVGVQHAPDSVLSVQWPEIPVDEELEPVTGQALRDFILEQRKIRDIAKVVNLRSRPGFSFVGDDLDKVRSLLRSVLSALAVFHNPLDVKLMVVTRHPELWSWMVWLPHNQHDELFDACGWRRLVFTSPTELESTLGADLHMKGKRGAWRPPSAPSPTTMGSALESGGDGLDLGPHWVIVDDNTGSPEAWESVVGRVGKEGITVLRVASRLGTGVGFARDEIFEVVDHPARHNRTDGPASTHRRNGRGADPSLPPMLRAGGKFFAHADQLSVPRAYRYARAMARWTPTASVDVTDSGSGALELLRALGIDDARELNVDRLWAERRSRGDERWAEIPVGAKPNGELQNIVLRAKDFGGFGFHSVVIGTSGSGKSEFFLSLVYGIALTHSPETFNVIFVDMKFESAAQDILGIPHVSAALSNLGKDDRHLAERMRRAIDGEIARRYRLFNSVGARDANDYEEIRLAGRDLEPVPILLVVIDEYLELFANHGKWIDLIIHIGQEGRGANVFFMLGGQRLDLSSLQKVKSNIAFRVALRAESGDDSREVIGSDAAYHLPSKENGFGLLKVGPRDLDPFRCFYLSAPFIVPKRKASTAKTLDMTLTKPRLYTWQYQPLDEADAQALQDMSATDAEPDEYLLHADGFKKKKIVDVLRESLISADRKAPHLPWLPPLEVSESADSLVALYRGKPWDVDYGRNPGLVWPLAVKDIPEDAQQLVHCVDVLRSNVMVVGAKSRGKTTALMTLMCSAALMYTPARLTFFCVGGATLGYAETLPHVADIVSPADREGVERTVATMAALISARQDTFRRDKIDINEFRERRFGAGSDGLGGTDPGDPYGDVFLVIDDFSDLYAADTVLGDRIIALSGVGPEYGVHLMTSASGWIHGQRQTLLQNSDVRIQLRLQNPGENEMGTASLDARDAAKRTVNRPGFGLTESLHEMLIGMPELTARDGSRIGTRDLGTRVAEVAGVTKHATLKRLPPAVALSEVLAYDVAQRPPAQTAPSIAFMIGEQHDLLPVPLELGEHPGMMILGRALCGKSATLAAIGEAVMARFSPEQAQITIIDPKTGPLRDLQGPGYVNAYAYDQDEIDEVLTTLAQQVLLPRLPAKGLSQEELRALKPWEGPRHFILVDDVQDLRPAQIHPAKPPVGAALWKLMERGRQIGLHVFATRNSSNFGQLEMDPWVKTQRSAKAPTLFMDNDPQNKVSRTVRAQALPAGRGLLVLDDSRVEGVLVGVPSSMIHNFEQQ
>NC_015576.1|WP_041316640.1|57993_58296_-|PE-family-protein
MFSVEPEAVLASSGVEAAITAETAAAASSASPALLGVLPMGNDPDSIAFQAALLASGSEYLGIVAEHSAQRGLYSGAQSTAAGVYSATEALRAATAALSG
>NC_015576.1|WP_013826999.1|56796_57990_-|PPE-family-protein
MADPGWAARPPEVNDTLIKSGMGVATMLANGTAWTTLGAAHHASGIASAVNTALTSVGWIGAGSASSALNATLLNVALHGLAGWVDMKAPIVAAAVEAYQLAYGSMRTTQECEANRIETATDYGINPIVLGALWPRITSLEYEYFGMFWPNNAAVGASYGATLTALTSSLTVPAPVAGMGASPAAPAAAASAVGDAAAQTAAGGAMRAAYTGTSAASNTAGQGASAAQGMGGEMSSLLGPVQSIGSSLMQAPQSLMQMPQSMMSPMQSMMGMFMNPSMFGGALNAAGAGGAPATAMLANATATPGGGVGGGGVGGAGAPVSAFTRPVSAFESGGGRPVGLRPSGALGSVESQQRVTTTSGAGMGGMPIGHAAGAAGRGQSGRSSDRANTVRVVDDRL
>NC_015576.1|WP_158019415.1|69620_69968_+|hypothetical-protein
MLAVVGVLVPPGVVPLVPAVVGVLVPPGVLALLPLPAAPPSVPVPILGVLVPPGVAPTVPLPPMPASLPVSLVGALGAPLPVAPPPPSTPPPLCAVLSRSSALMCCLGGVPKFAP
>NC_015576.1|WP_081465615.1|70490_70967_-|hypothetical-protein
MTPAPWPAPATAQPGHRSALVLATLAALLAVGALVVAVLALNKSTGTATYTTEQKSAAKNQLCERYKLAAHAMHIETSTPDNATFARISATNGALIIDVAAADPALDARYRDAAHNLTISYLDLTALGTAGMSDATSYQQAVDTLNARDHVMQELCGE
>NC_015576.1|WP_013827009.1|71151_71637_-|nuclear-transport-factor-2-family-protein
MIASRRWYAGIGSLLVTSVLVTSCSSSLTAGTPVTEHSASPAPSAVAPPSPPAPEPPPPPSDDDQIRQTVQAFQDAYNTQNWDAYKEQMCPAMRDQFTDGPVMDLLKKTRADGGLTRATVSAVDIDGDVATVTLDSQNEASGNLAPTLRLERGDGWKICVR
>NC_015576.1|WP_041316649.1|71682_73359_-|sensor-domain-containing-protein
MFTAGQVVDGYRIEQVLGTGGMGTVYLAANPTLPRREALKILSAELSRNSDFRARFIREAEVAAGLDHPHIVSVYNRGQTADGQLWIAMQFVDGTDADAAQRSGTMTPQRAVHIVSDVAKALDYAHARNVIHRDVKPANFLLTGTPGADERALLADFGIARALDDVGLTATGSVLATIAYAAPEVLSGTHLDGRADIYSLGCTLFSLLTGYAPFSSANGMAAVMMAHLHQPPPRPTDFVPSLPPALDVVIATAMAKDPAARFPSASALAQAARAALSNQLPAGLHYATPQSTPVRQPERPSSPRRRTWVLAGGAAAVLMVAGSIAAATMAGRERPPEPTTVVTSNTPAHSTIPLAGAEPGAPQGAASDDVQPEALRPILLPAGQLRSTEHELVLEEDISTLLDDAAAVSAPDCVGTWAPVQERAMGGHGQTGVAVQVLRAMNRKATEEGVVQAVVSYPTHMAAVQSLQQQQRQWQGCAGQSITVAAPGSGPQTWDFDQSQTFAGTVTSAARLRDGTAVCQHGINVRGNVLIDIRQCLPRGGNDVSALVNATGDRVPSR
>NC_015576.1|WP_013827011.1|73470_73824_-|VOC-family-protein
MSDHDIRMIVLSTDDLDESIKFYSETLGMPLKFRDGTHFAALDGGSVTLALATAVDHPIHGQVVVGIKTDDVDGAAKAIEASGGGIVKGPYDDAHERRAVVYDNKGNGLVFYKPLAR
>NC_015576.1|WP_013827012.1|73895_74024_-|membrane-dipeptidase
MPPETWLGLREHLAARGWADADIAAVLGGNFHRVAREAWRAV
>NC_015576.1|WP_013827013.1|74226_74838_+|GNAT-family-N-acetyltransferase
MAIDVRPANKPDIAPLAHTLGRAFYDDPVSMWMLPDDASRTAQLTAFFGTSTRVHHLSGGGVEVAYDGATVGAAALWDPPDRWKQSTWSQLRMVPSLIRSFGFRLSQGRALSDLLDANHPEEPHWYLAVIGSDPSVRGRGFGQAVMQPRLERCDAESCPAYLESSKEENVPYYERFGFRVIGEISLPNGGPTLWKMWREPQNP
>NC_015576.1|WP_013827014.1|74841_75960_-|nitronate-monooxygenase
MKTPICEQYGIDFPLFAFSHCRDVVAAVTNAGGFGVLGGAAYTPEQLDQELSWIDEQVKGKPYGIDIIVPAKFEGKGESLSGRQLSDRIPAEYQTFIANLLAEHDIEPDDKPRLGPAMLAGSAGEQLLEVAVAHPIRLMANALGVPPDYMIKSGQDHGIPVAALVGAKEHALKQVTHGVDLIVAQGTEAGGHCGEVSTLVLVPEVIDAIDDAVPVLAAGGIVTGRQMAACVALGAAGAWTGSVWLTTEEAETAPHTKQKMLAATSRDTIRSTGRTGKPARQLVSEWTDAWRPNEAGHPTLPLPLQSMLAEPALRRVDALAAAGHPGAQALATYFVGQGVGLMNKVKPAREVVFEFAQDYLAAAERLGDSVGE
>NC_015576.1|WP_013827015.1|76018_77479_-|alkaline-phosphatase-family-protein
MTTLKQILCGTAVAGLVAGAGAAVEPQVGLSTVTADWLLAAEHVLLLGTDGTNLDKILEYAYNDDSGFKMLMDRGVTAATTIAGHQTMSTPSWSTILTGVWDDKHGVVSNVYRPEPYTTWPSVFNLIEYHKPEVDTTVISGRGLFTEMASTGGYPADNIIGITGGSTSAEMDALVTDETIARILATTENPDTSTFMFSYQSQVDHAGHSYSGGSEEYKEAVINVGANFKQILDAVAQAEAATGDRWTIIAVTDHGHQQTVTLPGFSLGHGFQTPNETSSFIMFSLAGNDDQAGGQNLSYQTVDITPTILQAFGIQMRSDFDGVPMQTDPEILNGFIMPVDLKQSLTDAINSYGYPDIGTNIMLSIRALAGGAGFFIGSYLLPPISNFLQTIIDQDIFLISGLAQGAQWLLNTVGGVVADVATDLGRAVAYLTGAGVIPPEDAPLPLPGSAEFSDSVAALLAGHTVAVPDLVDADLPLLVDIDALVG
>NC_015576.1|WP_013827016.1|77485_78946_-|alkaline-phosphatase-family-protein
MTTIKQFLCGATVAGMVAATGAAVGAPAGLSAVTADWLLAAEHVLLIGLDGVNLSKVLEYAYDDDSGFKTAMDQGITGAASLTNHTTLSGPSWSTILTGVWDDKHGVFNNLFRPEPYNQWPTVFNLIEYNKPEVDTTIISNWEYLNQLAGAGGYSVDNNIFVPAGDSPADSDALVTALTIAQILGTEDNPDDISSFLFSYQSQADHAGHSFAGGSDEYMQSIINLGANLQQILAAIAHVQAITGDDWSVILTTDHGHQQTVTLPGLSIGHGFQSPNETSTFVIFDQAGDDANDGSQSLGYSTVDITPTILSLFGIPLRSDFDGVSLADDPTVLNGHVTPVDLEQALLAAIAMYGYPNIGNDITLAIRTVIGSVPYFLDKFVTEIDTFLQSIVDQDIFLISGLAEVAQQINEFFGGLTVNVTNTVAHGFAYLLGSGVIAPTDAPLPLPGAAEFTGSLESLLAGDTFTAPDIGDLDLSLLLDVDALLG

Crispr_ID: NC_015576_3

• CRISPR_ID: NC_015576_3
• CRISPR_location: 225027-225107
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_015576_3

Consensus_repeat	Method
TGGCCGCCTGCGCCGCCCGGCTGG	CRISPRCasFinder

spacers of NC_015576_3

>3.1|225051|33|NC_015576|CRISPRCasFinder
GCGCCGGACGCGAACTGGGCGCCGGATCCGTCG

CRISPR arrays and Neighbor proteins around NC_015576_3

CRISPR arrays

The CRISPR arrays of NC_015576_3

>merge|NC_015576|3|225027-225107|CRISPRCasFinder
TGGCCGCCTGCGCCGCCCGGCTGGGCGCCGGACGCGAACTGGGCGCCGGATCCGTCGTGGCCGCCTCCGCCGCCCGGCTGG

>NC_015576|3|3|225027-225107|CRISPRCasFinder
TGGCCGCCTGCGCCGCCCGGCTGG	GCGCCGGACGCGAACTGGGCGCCGGATCCGTCG
TGGCCGCCTCCGCCGCCCGGCTGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015576.1|WP_041319374.1|233975_235340_-|3-oxoacyl-ACP-reductase	unknown	unknown	gnl|CDD|236207
NC_015576.1|WP_013827163.1|230337_230511_-|DUF2613-domain-containing-protein	unknown	unknown	gnl|CDD|378543
NC_015576.1|WP_013827168.1|233131_233974_-|dehydratase	unknown	unknown	gnl|CDD|366711
NC_015576.1|WP_013827155.1|219250_219709_-|MarR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|197670
NC_015576.1|WP_013827157.1|221183_221786_+|NAD(P)H:quinone-oxidoreductase	unknown	unknown	gnl|CDD|179647
NC_015576.1|WP_013827164.1|230699_231887_+|beta-glucosidase	unknown	unknown	gnl|CDD|366376
NC_015576.1|WP_013827171.1|237010_237724_-|DJ-1/PfpI-family-protein	unknown	unknown	gnl|CDD|153233
NC_015576.1|WP_041319370.1|219861_220959_+|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl|CDD|274934
NC_015576.1|WP_049792810.1|217628_218204_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228
NC_015576.1|WP_041319366.1|215600_216158_+|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|366102
NC_015576.1|WP_013827158.1|221876_222560_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228
NC_015576.1|WP_013827159.1|222556_223498_+|R2-like-ligand-binding-oxidase	unknown	unknown	gnl|CDD|236242
NC_015576.1|WP_013827166.1|232656_232797_-|hypothetical-protein	unknown	unknown	unknown
NC_015576.1|WP_041316745.1|231964_232591_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228
NC_015576.1|WP_013827160.1|223510_224890_-|NADP-dependent-succinic-semialdehyde-dehydrogenase	unknown	unknown	gnl|CDD|181826
NC_015576.1|WP_013827154.1|218218_219196_-|phosphotriesterase	unknown	unknown	gnl|CDD|366928
NC_015576.1|WP_013827162.1|226010_230288_-|DUF3367-domain-containing-protein	unknown	unknown	gnl|CDD|378735
NC_015576.1|WP_081465616.1|235365_236838_+|acetyl-CoA-C-acetyltransferase	unknown	unknown	gnl|CDD|236440
NC_015576.1|WP_013827152.1|216204_217533_-|DUF2236-domain-containing-protein	unknown	unknown	gnl|CDD|378343
NC_015576.1|WP_133054404.1|232917_233115_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015576.1|WP_041319374.1|233975_235340_-|3-oxoacyl-ACP-reductase	gnl|CDD|236207	PRK08261, fabG, 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional.	0
NC_015576.1|WP_013827163.1|230337_230511_-|DUF2613-domain-containing-protein	gnl|CDD|378543	pfam11021, DUF2613, Protein of unknown function (DUF2613). This is a family of putative small secreted proteins expressed by Actinobacteria. The function is not known.	4.37114e-15
NC_015576.1|WP_013827168.1|233131_233974_-|dehydratase	gnl|CDD|366711	pfam01575, MaoC_dehydratas, MaoC like domain. The maoC gene is part of a operon with maoA which is involved in the synthesis of monoamine oxidase. The MaoC protein is found to share similarity with a wide variety of enzymes; estradiol 17 beta-dehydrogenase 4, peroxisomal hydratase-dehydrogenase-epimerase, fatty acid synthase beta subunit. Several bacterial proteins that are composed solely of this domain have (R)-specific enoyl-CoA hydratase activity. This domain is also present in the NodN nodulation protein N.	2.64754e-16
NC_015576.1|WP_013827155.1|219250_219709_-|MarR-family-transcriptional-regulator	gnl|CDD|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	4.6717e-14
NC_015576.1|WP_013827157.1|221183_221786_+|NAD(P)H:quinone-oxidoreductase	gnl|CDD|179647	PRK03767, PRK03767, NAD(P)H:quinone oxidoreductase; Provisional.	4.26291e-51
NC_015576.1|WP_013827164.1|230699_231887_+|beta-glucosidase	gnl|CDD|366376	pfam00933, Glyco_hydro_3, Glycosyl hydrolase family 3 N terminal domain.	3.19772e-83
NC_015576.1|WP_013827171.1|237010_237724_-|DJ-1/PfpI-family-protein	gnl|CDD|153233	cd03139, GATase1_PfpI_2, Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus. Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus. PfpI is an ATP-independent intracellular proteases which may hydrolyze small peptides to provide a nutritional source. Only Cys of the catalytic triad typical of GATase1 domains is conserved in this group. This Cys residue is found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow.	1.57025e-76
NC_015576.1|WP_041319370.1|219861_220959_+|LLM-class-flavin-dependent-oxidoreductase	gnl|CDD|274934	TIGR04036, family_protein, putative luciferase-like monooxygenase, FMN-dependent, CE1758 family. This tightly conserved subfamily of the bacterial luciferase-like monooxygenase (LLM) family, with members showing > 60 % pairwise sequence identity, includes proteins from both species with and species without the ability to make coenzyme F420. Therefore, the like cofactor is FMN rather than F420. The presence of three members in Kineococcus radiotolerans SRS30216 and two in Saccharopolyspora erythraea NRRL 2338 suggest closely related (subfamily) rather than exactly conserved (equivalog) function. Gene neighborhoods around members are not conserved. [Unknown function, Enzymes of unknown specificity].	0
NC_015576.1|WP_049792810.1|217628_218204_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	6.077e-06
NC_015576.1|WP_041319366.1|215600_216158_+|helix-turn-helix-transcriptional-regulator	gnl|CDD|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	7.64685e-13
NC_015576.1|WP_013827158.1|221876_222560_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	6.71823e-09
NC_015576.1|WP_013827159.1|222556_223498_+|R2-like-ligand-binding-oxidase	gnl|CDD|236242	PRK08326, PRK08326, R2-like ligand-binding oxidase.	0
NC_015576.1|WP_041316745.1|231964_232591_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	4.89597e-18
NC_015576.1|WP_013827160.1|223510_224890_-|NADP-dependent-succinic-semialdehyde-dehydrogenase	gnl|CDD|181826	PRK09406, gabD1, succinic semialdehyde dehydrogenase; Reviewed.	0
NC_015576.1|WP_013827154.1|218218_219196_-|phosphotriesterase	gnl|CDD|366928	pfam02126, PTE, Phosphotriesterase family.	1.7503e-147
NC_015576.1|WP_013827162.1|226010_230288_-|DUF3367-domain-containing-protein	gnl|CDD|378735	pfam11847, DUF3367, Domain of unknown function (DUF3367). This domain is functionally uncharacterized. This domain is found in bacteria and archaea. This presumed domain is typically between 667 to 694 amino acids in length.	0
NC_015576.1|WP_081465616.1|235365_236838_+|acetyl-CoA-C-acetyltransferase	gnl|CDD|236440	PRK09268, PRK09268, acetyl-CoA C-acetyltransferase.	0
NC_015576.1|WP_013827152.1|216204_217533_-|DUF2236-domain-containing-protein	gnl|CDD|378343	pfam09995, DUF2236, Uncharacterized protein conserved in bacteria (DUF2236). This domain, found in various hypothetical bacterial proteins, has no known function. This family contains a highly conserved arginine and histidine that may be active site residues for an as yet unknown catalytic activity.	2.70258e-06

Protein sequences

>NC_015576.1|WP_013827160.1|223510_224890_-|NADP-dependent-succinic-semialdehyde-dehydrogenase
MPAIATTNPATGETVKTFTAATETQIEAAIARAAARFADYRRTDFAQRARWTHAAADLLEAEADDVAAMMTLEMGKTLTSAKAEALKCVKGFRFYADHSEALLADEPAPDASAVNASKAFARYQPLGVVLAVMPWNFPLWQAVRFAAPALMAGNVGLLKHASNVPQTALYLEDLLSRAGFPDGCFQTLLIGSGAVERVLRDPRVAAATLTGSEPAGRSVAAIAGDEVKHTVLELGGSDPFIVMPSADVDAAVTTAVKARVQNNGQSCIAAKRFIVHTDVYDDFVTEFTAQMSALRVGDPTDPDTDVGPLATEQGRDEVEQQVDTAAAAGAVIQCGGKRLDRPGWFYPPTVITDITRDMALFTEEVFGPVASVYRVADIDEAIEIANATTFGLGSNAWTRDDAEISRFADEIEAGQVFINGMTVSYPELPFGGIKRSGYGRELSGHGIREFCNLKTVWVA
>NC_015576.1|WP_013827159.1|222556_223498_+|R2-like-ligand-binding-oxidase
MTRTHYDSLAAGGLNWDSLPLKLFAGGNAKFWNPADIDFSRDRDDWESLTDRERDYAVRLCAQFIAGEESVTQDIQPFMAAMRAEGRLGDEMYLTQFAYEEAKHTQVFRMWLDAVGITDDLHGYLDALPSYRRIFNEELPESLAGLSVDPSPASQVRAAVTYNHFVEGTLALTGYYAWHKICVQRGVLPGMQALIGHIADDERRHMAWGTFTCRRHVAADDANWEVFETRMNELLPLLVSYNAEGSEIYGEDVPFGLSSDELLQYSMDKGMRRFGTISSARGRPVGEIDLDYSPVQLEDTFADEDRKMLAVSA
>NC_015576.1|WP_013827158.1|221876_222560_+|TetR/AcrR-family-transcriptional-regulator
MPTVTWGRVDPARRAAVLEAAEAEFSARGFSHGSLNVIARRAEVAKGSLFQYFADKADLYAFVADTAGQRVRSYMERRIVDLDPSRPFFEFLTDMLDVWVAYFADHPRERALHAAASMEIDTDARISVRTVVHRHYLEVLRPLVDDAQARGDLRADADTGALLSLLLLIVPHLALAPYLRGIDPVLGLDEHTPEQPALAIRRLVAVLAAAFGGERTRHRHQSEEAVP
>NC_015576.1|WP_013827157.1|221183_221786_+|NAD(P)H:quinone-oxidoreductase
MTKLAVIYYSATGHGTAMAQRVARAGEAAGAEVRLRHVEETRDPATFAQNPAWSANYEATKDLPAATGDDIVWADAVIFGSPTRFGSPAAQFRTFIDGLGGLWAKGELADKVYAGFTSSQTTHGGQESTLLNLYVTLMHFGGILVPPGYTDPVKFADGNPYGVGHITGPENKNELNEATLAALDHLATRVVGVAAKISGA
>NC_015576.1|WP_041319370.1|219861_220959_+|LLM-class-flavin-dependent-oxidoreductase
MQFGIFTVGDVTTDPTTGRTPTEAERIKATVTIAKKAEEVGLDVFATGEHHNPPFVPSSPTTLLGYIAAQTERIQLTTATTLITTNDPVKIAEDYSVLQHLADGRVDLMLGRGNTGPVYPWFGKDIRAALPLTVENYRLLRRLWREKVVDFSGEYRAPLHGFSLAPRPLDGVPPFVWHGSIRTPEIAELAAYYGDGFFANHIFWPPSHTKAMVQLYRQRFEHYGHGSADQAIVGLGGQVFMRPNSQDAVEEFRPYFDNAPVYGHGPSLEEFSAQTPLTVGSPQQVIDKTLGFRDYVGDYQRQLFLIDHAGLPLKTVLQQLDLLGEHVVPVLRKEFAIGRPTHVPGAPTHQSLVEAAAAPEIGRAS
>NC_015576.1|WP_013827155.1|219250_219709_-|MarR-family-transcriptional-regulator
MGTEWLSVEEHRMWRAYLDSTRLLLRALDRQLATDSGITLSDFEALALLSEAPEHRMRMNELADITVTTRSGVTRAVKRLTEAGWVRQVKCDEDKRGLYAELTESGHDKLRQAAPGHVNAVRTNLFDLLSPRQVELFAHSYAQIRDNLLADP
>NC_015576.1|WP_013827154.1|218218_219196_-|phosphotriesterase
MSQCHTARGPIDTADLGVTLMHEHVFIMTTEIAQNYPDAWGDEDVRVTDAITRLGALKAAGVDTIVDLTVIGLGRYIPRIARVAAGTDLNIVVATGVYTYNDVPFFFHYRGPGTMLDGPEIMADMFVRDIESGIADTGVKAAILKCATDEPGVTPGVERVLRAVAQAHRRTGAPISTHTHAGLRRGLEQQRIFEDEGVDLSRVVIGHSGDSTDLGYLEELIAAGSYLGMDRFGIDLILPFEDRVNTVAALCERGHADKMVLSHDANCYFDALPNELSSVAAPNWHYLHIHNDVIPALRQRGVTDEQLRTMLVDNPRKIFEHSGGY
>NC_015576.1|WP_049792810.1|217628_218204_+|TetR/AcrR-family-transcriptional-regulator
MTAEARRGQILDVTHAIVDAEGFHAATPNRIAGEAGINRSLIYQQFGDPAGLFVALIDREAARAGAQFAEVISETTDSAGGGGLVSSFDSVLRAVDAHPATWRLFLFPPQGAPPELHERLARAQAVVRGYLVGELLRVYPDLPDPEYTARMVQAAARELLQLRLSDPDAATHERLHALVRSFAVRADSPSR
>NC_015576.1|WP_013827152.1|216204_217533_-|DUF2236-domain-containing-protein
MPAFYPELAQRVRSQRELHPGLYGAIDFDAQPYRTTTDPADRTALPEWVADRAPYLADARAVELICTATLLGDVVADPYAALMSEYSVTALIDMLRLACREGIDAVPDAPPELVAFIADMEATPPWLDMDLVREGARYARIPAALVAPFVTRGAFIATFVNTYAALPMALTGALSGKRAARRVNETTSFFAVTTLPGALERHGPGFEAAAMVRLMHSMVRYNALKRSEKWDVGVYGIPIPQVDQMPAGMINLYLLALAARRRGRAEFTASERAIVEFTRYRAFLLGLPEELLPTTPTGVIHLIHTRGALLREDFDDATCGEMVRSTMAAYLRPVDTRWERMAEAVEKSYSKVAFLKAFCNGDRSVAEAKGVSVGPADYLRIGVTAPFILGRLLAVRRASRIPALRRITDDYVVRLVKRRLKTYGKPEFTSDARDYTPAGQLA
>NC_015576.1|WP_041319366.1|215600_216158_+|helix-turn-helix-transcriptional-regulator
MTGTAGAILAAARVEFTRHAFRRANIDAVAQRAGVSRRTLYRHFPTKEALFEHLVEADTQALFAELGQAARRQDAAGAIVECFTLAMRRITENPLVTAVIESEPELVIGLNTPNGERAFVRVSNLVASTLRLCGVTMPDESVLATAEILVRLVGSLLTNRAGVLDITDTVAVRKYAETYLARLVW
>NC_015576.1|WP_013827162.1|226010_230288_-|DUF3367-domain-containing-protein
MTMLSRRWLWLVGAVALACSFIQAPGRISPDTKLDLTADPLRFLTRAVNLWSSELPFGQVQNQAYGYLFPHGAFFLLGDFVGLPGWIIQRLWWALLLTVGFWGLLRVAETLRLGTPTARLIGAAAFALSPRVLTTMGSISSETLPMMLAPWVLLPVIRALGAPGSETPGRPVRALAGQAGVAVALMGAVNAVATLAGCLPAIIWWLCHRPNRRWWSFTGWWLLALALAVTWWLVALLLLGRVSPPFLDFIESAGVTTRWTSLTEILRGTHSWTPFVAPNATAGAPLVTRPVLILGTCLVAAAGLAGLTGMLRRRLPGAGRLITMLLIGVTLLAVGYAGGLGSPLAHAVQTFLDADGAPLRNVHKLESVIRLPLVLGVTYLLGRIPLPGSAPAAVWRRAYVHPEHHKAAAVGLVVLTALMVSTSLAWTGRLTPPGTFQDLPQYWRDAAAWLGEHNTGGPTPGRVLVVPGAPFATQTWGTSHDEPLQVLSETAGGPWGVRDSIPLTPPQTIRALDSVQRLFAAGRPSAGLADTLARQGISYLVLRNDLDPDTSRSARPLLVHRAVDGSPGLHRVAQFGNPVGSGTVPGFVSDSGLRPAYPAIEIYRVGDPAAGANPGAPYLADLDAMRRVAGGPEVLLRLDEHRRMRGEPVLGPVLMTADARRAGLGAPRNGGITVTDTPLARETDYGRVDDHSSTLRAAGDARHTHSRVPDYPTPGAATVFGGWIGGRITASSSSSDATALPDVAPSTSPAAAIDGDSGTAWVSNALQSAVGQWLQIDFDHPLTNGTITVTPSATAVGAQVRRIQISTVNGTTTLRFDHAGEPLTAALPYGETPWVRITASGTEDGSPGVQFGITDLSVTQYDASGYAHPVDLRHTALVPAPPAGARVSQWDLGAGLPGRAGCAAASGAVRCAASMMLEPEEPATFSRTLNVPQPISVTPTVWVRPRQGPHLVDLIAEPGAARARGDADVLDVLGSAYAAADGDPGTAWTASQRVVAHRSPPTLTITLPRPVEVAGLRFAASRSPLPARPTLVAIDLGSGPQVRELADSDEQRVGLQPRVTDTVSISLLEWQDVIDRTAIGFDQLKPPGLAEVSVLGADGRPIAPADPARNRARRVTVDCGHGPIVAIAGRFVHTSITTTVGALLDDEPVRAQPCDQRPIALPPGAQELLISPGSAFVVDSATLSGPLATRDGVGTATTPAVVGTWSPARREVTVSDASATRVLVVPESINRGWVARTPDGSRLVPVAVNGWQQGWVVPAGTDGTITLRFGPNRMYRLGMAGGLALLPMLALLACWPARRIRSPGPPARPWQPSRGQLGIAVLTVGTLIAGAAGAVVFGAALIAMFALRHRQRAFDATRLGLSSGGLILAGAVLCRHPWRSVDGYAGHSAGVQLAALVSVAVLAATAAVVSSGGRDPGEPPRRAGM
>NC_015576.1|WP_013827163.1|230337_230511_-|DUF2613-domain-containing-protein
MPRFVVPAAISIVVGVLLGAAAVFGVTLMVQQDTKPQIAGGDPQSSVLNRVEYGNRG
>NC_015576.1|WP_013827164.1|230699_231887_+|beta-glucosidase
MPASLTRHLPGLLLAAALLPALTTACSHRTETPAPSTPAESTDTSTAAAPVDPACKQLAALPVRDKLAQLVMVGVRDAADARAVVTDHHVGGIFIGSWTELSMLTDGSLTEIKEDQAAAGPLPLAVSVDEEGGRVARLSSLIGSSPSAKELAATHSAAQVRELAAERGRKMADLGITIDFAPVVDVVAAGTDDDTVIGDRSFGSDPAKVTEYAGAYAQGLRDAGLLPVLKHFPGHGHGSGDSHTAGAVATPPLAQLQDNDLVPYRTLVTQAPVAVMMGHLEVPGLTEDPASLSPAAVSLLRAGTDYHGPAFSGLVFTDDLSSMAAITEHYGVADAVLRSLQAGVDIALWVTTDEVPAVLDRLEQAVAAGELKREAIDASLARLAAVKKPGTHCHG
>NC_015576.1|WP_041316745.1|231964_232591_+|TetR/AcrR-family-transcriptional-regulator
MAAGSKRLPRAVREQQMLDAAVQMFSINGYHETSMDSIAAAAQISKPMLYLYYGSKEELFGACLDRELARFVETVRTSIDFQQSPKDLLRNTIRSFLHYIDTNRASWIVMYSQATSSQAFAHTVREGRERIVELVGRLLRAGTRNPEPGVDFDMMAVALVGAGEAIASRVSTGDTDVDEAGELMIDLFWRGLKEAPGGRDGAESAAAG
>NC_015576.1|WP_013827166.1|232656_232797_-|hypothetical-protein
MLTTAPAYAANLFAQELGSGDILNALGMPIAGLFGLAASPSDSNSS
>NC_015576.1|WP_133054404.1|232917_233115_+|hypothetical-protein
MVTSAEALAAPTPGFSARAYMDTVMVVVRGLVMSIPVWGIDVVSARWQVSKANLLRAAGLAAEIG
>NC_015576.1|WP_013827168.1|233131_233974_-|dehydratase
MTQPSGAKNMLRAVAGALPFIPRSGALPDRTLRVDDLAIDAGHVAEYAAVTGLRYGNHVPVTYPFALTFPTVMSLVTGFDFPFAAMGSVHTENRITQYRPIAVTDTVDVEVHAENLREHRKGLLVDIVTDLHVGNDLAWHQVTTFLHQQRTSLSDEPKPPPAKQPKLGPPNVVLRVTPGQIRRYASAGGDHNPIHTSSIGAKLFGFPTVIAHGMFSAAAVLANIEGTLPDAVDYTVRFGKPMLLPAGPGLYVDRVEGGWDLSLRNIAKGYPYLTGAVRAL
>NC_015576.1|WP_041319374.1|233975_235340_-|3-oxoacyl-ACP-reductase
MAPKLPTDLLSQILNSAPGSFLSKQLGVPQAETLRRYRVGEPPLAGPLLIGGSGRVVEPLRTALAGDYEVVGDNLGGRWADSFGGLVFDATGINSPAGLTELHDFFTPLLRNVGRCGRLVVVGTTPEATGSVDERIAQRALEGFTRSLGKELQRGATVQLVYLSPEAKPGATGLESTMRFILSGRSAYVDGQVFYVGADDATAPADWDRPLEGKVAIITGAARGIGATIAEVFARDGAKVVAIDVPGAAEALNATAARVDGTALALDVTADDAVDQIAAHLKEHYDGNADILVNNAGITRDKLLANMDDARWNAVLAVNLLAPQRLTEGLVSRGSIGKGGRVIGLSSMAGIAGNRGQTNYAATKAGMIGLTDALAPVLADKGITINAVAPGFIETEMTAAIPLATREVGRRLNSLFQGGQPVDVAELIGYFASPASNAVTGNTIRVCGQAMLGA
>NC_015576.1|WP_081465616.1|235365_236838_+|acetyl-CoA-C-acetyltransferase
MWGRAWCRPRCRQRTYSRVRILGSITPIVPPVRGARPPDGEIVAPGSAAKPTPAEPGARRRVAVLGGNRIPFARSDGAYASASNQDMFTAALGGLVDRFGLAGEKLDAVIGGAVLKHSRDFNLIRESVLGSALSPYTPAFDLQQACGTGLQAAICAADGIAAGRYEVAAAGGVDTTSDAPLEVGNELRRTLLALRRSKSNLARLKLVGKLPATLGVEIPANKEARTGLSMGEHQAVTTKQMGIKRVDQDELAAASHRNMAAAYDRGFFDDLVTPFQGLYRDNNLRPESSPEKLATLKPVFGAKAGDATMTAGNSTPLTDGASVALLASEQWAAAHKLTPLAYFVDSETAAVDYVTGPDGLLMAPTYAVPRLLARNGLTLQDFDFYEIHEAFASTVLCHLAAWESEDYCKQRLGLDAALGAIDRSKLNVNGSSLAAGHPFAATGGRIVAQAAKQIAEAKAAKKGASKNKPVRALISICAAGGQGVAAILEG
>NC_015576.1|WP_013827171.1|237010_237724_-|DJ-1/PfpI-family-protein
MQIAIVLYPGFTALDFIGPYEVLRWLPDARVRFLWHEPGPITADSGVLVVAATHSFDETPSPDVILVPGGMTTTEHARDEKLLAWVRRAHSTATWTASVCSGSIILAAAGLLSGKRATSHWMALPALKAFGVTPIADERIVVSGDIVTCAGVSAGIDLGLWLAGRIGGEHRAKVIQLSLEYDPQPPFDSGHMSKASAKTKAAASALMAKDLATPSQLKAGALLLWDRAIGAARSRRG

Crispr_ID: NC_015576_4

• CRISPR_ID: NC_015576_4
• CRISPR_location: 346527-346651
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_015576_4

Consensus_repeat	Method
CCCGGACGCTTGGCCCCACCGGCCATCCCCAGCCCCTT	CRISPRCasFinder

spacers of NC_015576_4

>4.1|346565|49|NC_015576|CRISPRCasFinder
CACCGGGGCTGCCGGAGCAGCGGGTGCCGGCGCGGCCGCCTTCTTGGCC

CRISPR arrays and Neighbor proteins around NC_015576_4

CRISPR arrays

The CRISPR arrays of NC_015576_4

>merge|NC_015576|4|346527-346651|CRISPRCasFinder
CCCGGACGCTTGGCCCCACCGGCCATCCCCAGCCCCTTCACCGGGGCTGCCGGAGCAGCGGGTGCCGGCGCGGCCGCCTTCTTGGCCCCCGGGCGCTTGGCCCCACCGGCCATCCCCAGCCCCTT

>NC_015576|4|4|346527-346651|CRISPRCasFinder
CCCGGACGCTTGGCCCCACCGGCCATCCCCAGCCCCTT	CACCGGGGCTGCCGGAGCAGCGGGTGCCGGCGCGGCCGCCTTCTTGGCC
CCCGGGCGCTTGGCCCCACCGGCCATCCCCAGCCCCTT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015576.1|WP_158019420.1|337323_338031_-|hypothetical-protein	unknown	unknown	gnl|CDD|240291
NC_015576.1|WP_013827281.1|356793_357423_+|nucleotide-exchange-factor-GrpE	unknown	unknown	gnl|CDD|237623
NC_015576.1|WP_013827268.1|343289_343649_+|nuclear-transport-factor-2-family-protein	unknown	unknown	unknown
NC_015576.1|WP_041316792.1|339271_340678_+|hypothetical-protein	unknown	unknown	gnl|CDD|237030
NC_015576.1|WP_013827269.1|343680_344547_+|glucose-1-phosphate-thymidylyltransferase-RfbA	unknown	unknown	gnl|CDD|130274
NC_015576.1|WP_013827280.1|354949_356797_+|molecular-chaperone-DnaK	unknown	unknown	gnl|CDD|234715
NC_015576.1|WP_013827264.1|338545_339118_+|dCTP-deaminase	unknown	unknown	gnl|CDD|234753
NC_015576.1|WP_013827282.1|357446_358646_+|molecular-chaperone-DnaJ	unknown	unknown	gnl|CDD|237655
NC_015576.1|WP_041316800.1|353499_354801_+|cytochrome-P450	unknown	unknown	gnl|CDD|225035
NC_015576.1|WP_013827266.1|340744_342472_+|hypothetical-protein	unknown	unknown	gnl|CDD|237865
NC_015576.1|WP_013827261.1|335563_336385_+|glycoside-hydrolase-family-16-protein	unknown	unknown	gnl|CDD|185693
NC_015576.1|WP_041316796.1|344802_346107_-|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl|CDD|181738
NC_015576.1|WP_013827273.1|349213_349792_-|hypothetical-protein	unknown	unknown	gnl|CDD|237030
NC_015576.1|WP_013827277.1|351673_351856_-|hypothetical-protein	unknown	unknown	unknown
NC_015576.1|WP_013827278.1|351888_353370_-|amino-acid-permease	unknown	unknown	gnl|CDD|185009
NC_015576.1|WP_013827262.1|336381_337239_-|hypothetical-protein	unknown	unknown	unknown
NC_015576.1|WP_013827274.1|349859_350231_-|DUF3054-domain-containing-protein	unknown	unknown	gnl|CDD|378616
NC_015576.1|WP_049792820.1|350253_350916_-|hypothetical-protein	unknown	unknown	gnl|CDD|237030
NC_015576.1|WP_013827267.1|342501_343260_+|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	unknown	unknown	gnl|CDD|274422
NC_015576.1|WP_193374436.1|350963_351494_-|hypothetical-protein	unknown	unknown	gnl|CDD|237874

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015576.1|WP_158019420.1|337323_338031_-|hypothetical-protein	gnl|CDD|240291	PTZ00146, PTZ00146, fibrillarin; Provisional.	0.00210843
NC_015576.1|WP_013827281.1|356793_357423_+|nucleotide-exchange-factor-GrpE	gnl|CDD|237623	PRK14142, PRK14142, heat shock protein GrpE; Provisional.	1.65225e-75
NC_015576.1|WP_041316792.1|339271_340678_+|hypothetical-protein	gnl|CDD|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	1.41529e-09
NC_015576.1|WP_013827269.1|343680_344547_+|glucose-1-phosphate-thymidylyltransferase-RfbA	gnl|CDD|130274	TIGR01207, Glucose-1-phosphate_thymidylyltransferase_1, glucose-1-phosphate thymidylyltransferase, short form. Alternate name: dTDP-D-glucose synthase homotetramer This model describes a tightly conserved but broadly distributed subfamily (here designated as short form) of known and putative bacterial glucose-1-phosphate thymidylyltransferases. It is well characterized in several species as the first of four enzymes involved in the biosynthesis of dTDP-L-rhamnose, a cell wall constituent and a feedback inhibitor of the enzyme. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides].	1.30049e-177
NC_015576.1|WP_013827264.1|338545_339118_+|dCTP-deaminase	gnl|CDD|234753	PRK00416, dcd, deoxycytidine triphosphate deaminase; Reviewed.	1.21599e-97
NC_015576.1|WP_013827282.1|357446_358646_+|molecular-chaperone-DnaJ	gnl|CDD|237655	PRK14279, PRK14279, molecular chaperone DnaJ.	0
NC_015576.1|WP_013827266.1|340744_342472_+|hypothetical-protein	gnl|CDD|237865	PRK14951, PRK14951, DNA polymerase III subunits gamma and tau; Provisional.	2.2141e-14
NC_015576.1|WP_013827261.1|335563_336385_+|glycoside-hydrolase-family-16-protein	gnl|CDD|185693	cd08023, GH16_laminarinase_like, Laminarinase, member of the glycosyl hydrolase family 16. Laminarinase, also known as glucan endo-1,3-beta-D-glucosidase, is a glycosyl hydrolase family 16 member that hydrolyzes 1,3-beta-D-glucosidic linkages in 1,3-beta-D-glucans such as laminarins, curdlans, paramylons, and pachymans, with very limited action on mixed-link (1,3-1,4-)-beta-D-glucans.	1.77944e-36
NC_015576.1|WP_041316796.1|344802_346107_-|pyridoxal-phosphate-dependent-aminotransferase	gnl|CDD|181738	PRK09265, PRK09265, aminotransferase AlaT; Validated.	0
NC_015576.1|WP_013827273.1|349213_349792_-|hypothetical-protein	gnl|CDD|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	8.42653e-08
NC_015576.1|WP_013827280.1|354949_356797_+|molecular-chaperone-DnaK	gnl|CDD|234715	PRK00290, dnaK, molecular chaperone DnaK; Provisional.	0
NC_015576.1|WP_013827278.1|351888_353370_-|amino-acid-permease	gnl|CDD|185009	PRK15049, PRK15049, L-asparagine permease.	0
NC_015576.1|WP_041316800.1|353499_354801_+|cytochrome-P450	gnl|CDD|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	4.17417e-89
NC_015576.1|WP_013827274.1|349859_350231_-|DUF3054-domain-containing-protein	gnl|CDD|378616	pfam11255, DUF3054, Protein of unknown function (DUF3054). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.	8.17529e-27
NC_015576.1|WP_049792820.1|350253_350916_-|hypothetical-protein	gnl|CDD|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	6.69534e-06
NC_015576.1|WP_013827267.1|342501_343260_+|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	gnl|CDD|274422	TIGR03083, TIGR03083, uncharacterized Actinobacterial protein TIGR03083. This protein family pulls together several groups of proteins, each very different from the others. They share in common three conserved regions. The first is a region of about 38 amino acids, nearly always at the N-terminus of a protein. This region has a bulky hydrophobic residue, usually Trp, at position 29, and a His residue at position 37 that is invariant, so far, in over 150 instances. The second conserved region has a motif [DE]xxxHxxD. The third conserved region contains a hydrophobic patch and a well-conserved Arg residue. Most examples are found in the Actinobacteria, including the genera Mycobacterium, Corynebacterium, Streptomyces, Nocardia, Frankia, etc. The pattern of near-invariant residues against a backdrop of extreme sequence divergence suggests enzymatic activity and conservation of active site residues.	7.70912e-17
NC_015576.1|WP_193374436.1|350963_351494_-|hypothetical-protein	gnl|CDD|237874	PRK14971, PRK14971, DNA polymerase III subunit gamma/tau.	0.00205762

Protein sequences

>NC_015576.1|WP_041316796.1|344802_346107_-|pyridoxal-phosphate-dependent-aminotransferase
MDSYGTIVDVTAHQLPHQMPWPAIGSQLRQRTFAQSTKLQDVLYEIRGPIHAQAARMEAEGHRILKLNIGNPAPFGFEAPDVIMRDMIQALPHAQGYSDSQGILPARRAVVTRYELVEGFPRFDVDDVYLGNGVSELISMVLQALLDNGDQVLIPAPDYPLWTASTSLAGGTPVHYLCDETQGWQPDIADMESKITERTKALVVINPNNPTGAVYGREVLSQIAELARKHQLLLLADEIYDKILYDDAEHTNMAALAPDLLCLTFNGLSKAYRVAGYRAGWVAITGPKEHATSFLEGINLLANMRLCPNVPAQHAIQVALGGHQSIDDLVLPGGRLLEQRDVAWSKLNEIPGVSCVKPSGALYAFPRLDPEVYPIQDDEQLVLDLLLQEKILVTQGTGFNWPAPDHLRIVTLPWARDLSGAIERLGNFLVGYRL
>NC_015576.1|WP_013827269.1|343680_344547_+|glucose-1-phosphate-thymidylyltransferase-RfbA
MRGIILAGGSGTRLYPITMGVSKQLLPVYDKPLVYYPLCTLMLAGIRDIQVITTGHDAAAFHRLLGDGSAFGVDISYAVQDQPDGLARAFVIGADHIGAESVALVLGDNIFYGPGLGTSLRRHQAVSGAVIFAYWMADPSAYGVIEFNADGAAVSVEEKPATPKSHYAIPGLYFYDNDVVEIARGLKPSARGEYEITDINQAYLEQGRLSVQALARGTAWLDTGTFDSLLDAGDYVRTIERRQGLKIGIPEEVAWRMGFIDDDHLAARAETLRKSGYGDYLSQLLQRR
>NC_015576.1|WP_013827268.1|343289_343649_+|nuclear-transport-factor-2-family-protein
MSTSEIATVLAWHDALAAGDLETLEQLSSDGIEVADANGAAQGHQALRRWAAEAEITAGIGRMYVHDGVVVAELVPVGAGSAQAVAFRVVRDQVAAVFRHDGLDAALAATDLTEADRVD
>NC_015576.1|WP_013827267.1|342501_343260_+|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme
MDYAAALLDETRAFGELIRSGDPGLAVPSCPEWNLTQLFRHVGRGHRWAAQIVADRLDHALDPRDVVDGKPPADPDAAIGWLNDGAQRVLDGVAQVGPDNPAWTFLGPRPASWWVRRRLHEATVHRADAALALGGDFALPAELAADGISEFLDLITARVARDGQPPLADGQTVHLHATDDGLGQAGEWTISRSADNAALVWAHEHGKGSVALRGPARDLFLAIMGRVPVADTDIVLFGDAAVWQEWVEHTAF
>NC_015576.1|WP_013827266.1|340744_342472_+|hypothetical-protein
MDIVLGVSTAPPSVRMVLVEGENAGGVTVDEDGFEVDTAGAAFPDQVVSAILGTQESAQQGGYRLASTGVTVADQVQAGQLRDALADRRVENVMLVSAFLAAAALAQTVGGTIGYERTALMFIEPQGATLAVVDSTDGSITEVSRVALPPDDDAALAELTALAAQAGRLESRPDGLFVVGSGVNVGLVKPELDAVSAIPVSVPEEPDTALARGAALASAHAPLFDSSTSALAWARDPGTGVIDPNLVALAYAQQADYDATIGEYALAYSAIPEDADSGYLAFGDAENTANVIAADYHPPSSGVRRADELEPARRRNPFLLAGSGLAAFFVVGVASLLVALAVSIRPTASEHPAPSQHIVVPTQQAQAPVPEVAPKVPPAAPVPAAPAPAAPAPPVAQAPAAPAPMPAAPAPAAPAPAAPAPIPIPVPIQVPAPPVEIPSPAAPAPKQPELPPIFKPPAQSPPKNDNPSWLPGNNGGGNKKDNSSWLPGNNGGGNKGGNPSWLPGDNGGGNKGGNKGGNPSPWLPGVGTNGGGNNPWLPGLGGGGSGARGGGGGSWFPDFGGGGNGGGGGKGGWPF
>NC_015576.1|WP_041316792.1|339271_340678_+|hypothetical-protein
MVLVEGEGADGVTVEHDDFDVGADTQSAPERVVSAILGTREGAREGGYQLSSTGVTWSDPAEATALREALIGHKVENVMLVSAFLAAAALAQAVGSATRYARTALLFVEPDAATLAVVNSDDGEITEVHRQPLSPDDDSAVGELTELVAGAQRLESRPDGLFVVGSGGVNVAMIKPELDKASPLPVSAPEEPDMALARGAALASAHAPLFASSTRAVAWAQDPGTGSLDPAVVSSGYAYVPAEAVDYNATADIEPLAYSAVPDYTDSGYFPSAAERVADQPELVDSRLLDFTTGIQQRERKPMLVTGGVAALFVVGVLALAVALAVGMRAANHHGPDVRANVVKPPPSKAAVPSPAPPPQEAPPPVPAGEQAPPRAPAPAPRAPAPAPAPVAPAPPPALPPPPALPPPMIPDLNIPGLPGGPPILGPPKGGWDGDGGWGRGGPGKGGKGKGKGKGGIKIPIPIPGLHF
>NC_015576.1|WP_013827264.1|338545_339118_+|dCTP-deaminase
MLLSDRDLRAEIAAGRLALDPFDDTLVQPSSVDVRLDNLFRVFNNTRYTHIDPAQQQDELTTLVEPKAGEPFVLHPGEFVLGSTLECCTLPDDLAGRLEGKSSLGRLGLLTHSTAGFIDPGFSGHITLELSNVANLPITLWPGMKIGQLCLLRLTSPAEHPYGSTRVGSKYQGQRGPTPSRSYQNFIQSG
>NC_015576.1|WP_158019420.1|337323_338031_-|hypothetical-protein
MANRGSIGKGAARSRRRDRAVGAAASVGAFLTFGVMPSAPAQADEFDWIADVFDMSAWVDDGGASDAVNWFDPASWSLDGLAGSAAADDFTTWAETWIYQPFHTMMQNWMQTDFGIVFRYVLNESFGNGQILIGNGADGYSGGTLEEAAGQPGGLWFGDGGDGGTTASGVGGAGGAAYFGNGGAGGDGTDGAAGGSGGSVAYIGIGGDGGAGGAGGPGGDGGWLFGSDGNAGSPG
>NC_015576.1|WP_013827262.1|336381_337239_-|hypothetical-protein
MGLFPKPHATLTDAEVADALNRAVAVINPLLDLLAQSDPIGLRQRTRRLLSPPRGLTGRVRRFRLRRRRHEAGRGPSAADRARNAGAQLMNAADLPGTAAWERMSRDERVHWWVHRVGALNTVVVASPRVFGWLARVVPVGELAGFVNHAIVLCALAREYGVTDRREQVRLLAAVLCRRDLPGDLDVPPPPDPEPLPETPPPGWQPLKTITSSTPVVITRTVWQLAGILRATFEEAAKRPHPKKLYQRLSLLPGIGAIAGYFGERGALFRSAREGVAWLDQHTVA
>NC_015576.1|WP_013827261.1|335563_336385_+|glycoside-hydrolase-family-16-protein
MPEINRRSLMLTTGIGMLATAMRIPEAWAQPSPVGPLPAAPAQTYLFSDEFDGPAGSAPDSAKWTVARARESMKDPTFWERPENVGQYRDDRRNVFLDGKSNLVLRAAKDGNTYYSGKVQSRWTGGIGHTWEARIKLNCLTPGAWPAWWMGNEDRGEIDVLEWYGNGNWPSATTVHTKANGAEWATQQIALDSAWHTWRCRWDTDGIRFWRDYVDGAAPYFTVPANSIADWPFNDPGYQVFTVLNLAVAGSGGGDPGPGSYPAEMLVDWIRVF
>NC_015576.1|WP_013827273.1|349213_349792_-|hypothetical-protein
MERTPDDPNDEPTRMADYDYRGADRYDEPAGYYSEYRDPTGSQPGWSEPPEPPPAPWYLRPLALIGWGVLTALLIATLVWSMVRLVNKDSGDTTPATTSVTSTVAPPGESTAPNPVAPAPPGQEDAPPPATTATEPPATTTEPTTTTTTTTTEPTTTTAPTTTAPTTTQPTTTQPPTTTEAPPTTTAGTDGQ
>NC_015576.1|WP_013827274.1|349859_350231_-|DUF3054-domain-containing-protein
MRPQRDPAWLGIDVVAVLVFCALGRRSHDEGLDISGLATTAWPFLSGTVLGWLMSRGWRRPTAVVPTGVIVWISTVLVGMALRAATATGVAWSFVAVASTVTAVFLLGWRAVFELVARRRATR
>NC_015576.1|WP_049792820.1|350253_350916_-|hypothetical-protein
MARFGSSHGSGTPGDDPTRSTQYGQRGPQPPGPQPAPFGPAGPRHHPGDPGYQPGNAPTQYNPAYNPFEQQLPGDPDTEDFAAWAPTPWFRRRSVLTAWFGLILLMLALVIWGIVQLTSRGPGDGGTAPASSSSSTTAGTTSPTSTTSPTSTPPSASSTTAAPPPPRQAPPQQSPPRQPPAPSETHRHRPRLPSLPSVITIPPVPKVPELPTVITIPPYR
>NC_015576.1|WP_193374436.1|350963_351494_-|hypothetical-protein
MVLAAALLVAGCSTTVDGNPTAAPGGSGPPEPSLRTPRPTTAPPSTSTPAAPPSSSTPGKPGDAIALPPDENGYVFIETKSGRTRCQISTRQVDCEAEFTNSPLKGGEHANGVSVSSDGTVQWVLGNLGDIPVVTIDYLTYQAEGWKIDADVEGTRFTNDRTGHGMFVSIDNVETF
>NC_015576.1|WP_013827277.1|351673_351856_-|hypothetical-protein
MPGNRYAAKPPLYGMVLVFCAIAIVAVTAYLHGGWWSVLGYAFAAITAVAGGVLAFRDFS
>NC_015576.1|WP_013827278.1|351888_353370_-|amino-acid-permease
MSTVPDPHLAPPAALAREDEGYHKDLHPRQVQMIAIGGAIGTGLFLGAGRRLHEAGPALFLVYGICGIFVFFILRALGELVVHRPTSGSFVSYAREFFGEKTAFVAGWLYFLNWSMTGIVDTTAIATYFHYWGVFHVVPQWVLALIALVSVVSMNLISVKLFGELEFWAALIKVVALVTFLIVGTVFLGGRFQVDGQSTGLHLWVDNGGFLPTGLLPLVLVTSGVVFSYAAVELVGTAAGETAEPEKIMPRAINSVVARIAIFYVGSVVLLALLLPYTAYKHGESPFVTFFAKIGFNGAGGLMNLVVLTAAFSSLNAGLYSTGRILRSMAVNGSGPKFTAPLSGNGVPYGGILLTGAIGLFGVALNAVVPEHAFEIVLNIAALGVITAWATIVACQLRFFSLTKRSDLQRPAFRMPLAPYSGYVTLAFLAAVVVLMMFDPEYGVWIRTAVLVGGPGLVAGWYLVRNRVTAAAVPPTDTGEQPPAVAAQAEADE
>NC_015576.1|WP_041316800.1|353499_354801_+|cytochrome-P450
MWPGSWLRWALLHGLPRAFLAVQARRDEPLARLLVGPMRGGEPEPLIEQIRAAGSLTRTPFVSVTADHGLCRTILRDDRFGVSNPANMNLPRPVRWLISRTDPRLPNPAEPPSMLMVDPPDHTRYRRAVVRAFTPRAIEKLRTRIVEITDDLLDRLESASQPDLIADFAGPLPARIIAEILGIPEEMRPQLLDRGDRGAPLLDIGVSWKIFRHAMQSLRESDRDFGDHVERLRDQPGDDIFSQVIRDGDLDRRELGVTALLVVGAGFETTVNLIGNAIVLLLRHRDQLAMLREDPELWPGAVEEVLRFDSPVQMTSRNPLCDLELDGHRLAAGETVALLLGGANHDPDVFEDPGRFDITRVNAKDHLSFSSGIHACLGANLARMEAAIALRALFERFPDLALAGAPVPRGLATLHGFRCIPATTGASARPATA
>NC_015576.1|WP_013827280.1|354949_356797_+|molecular-chaperone-DnaK
MARAVGIDLGTTNSCVSVLEGGDPVVVANSEGSRTTPSVVAFARNGEVLVGQPAKNQAVTNVDRTIRSVKRHMGTDWKVEIDGKDYTAQEISARVLMKLKRDAEAYLGEDITDAVITVPAYFNDAQRQSTKEAGQIAGLNVLRIVNEPTAAALAYGLDKGHKEQTILVFDLGGGTFDVSLLEIGEGVVEVRATSGDNHLGGDDWDDRVVEWLVDKFKATSGIDLTKDKMAMQRLREAAEKAKIELSSSQSTSINLPYITVDADKNPLFLDEQLTRSEFQKITQDLLDRARKPFQSVIKDAGISVSEIDHVVLVGGSTRMPAVTDLVKELTGGQEPNKGVNPDEVVAVGAALQAGVLKGEVKDVLLLDVTPLSLGIETKGGVMTKLIERNTTIPTKRSETFTTADDNQPSVQIQVFQGEREIASHNKLLGSFELTGIPPAPRGVPQIEVTFDIDANGIVHVTAKDKGTGKENTIKIQEGSGLSQEEIDRMIKDAEAHADEDRKRREEADVRNQAESLVYQTEKFVTEQRDAEGGSKVPEDTLGKVDAAIGEAKKALEGTDIGAIKSAMEKLGVESQALGQAIYEATQAEQAADAGAASGGDDDVVDAEVVDDGDTK
>NC_015576.1|WP_013827281.1|356793_357423_+|nucleotide-exchange-factor-GrpE
MSEGDSREPAPEKITVTDKRRIDPETGEVRAGSAGPAPSEPAPADPVVDGGEVDQVAELTADLQRVQADFANYRKRALRDQQGVADRAKASVVTELLPILDDLDRARSHGDLEAGPLKALGDKLTSVLDGLGLAAFGVEGDEFDPLLHEAVQHEGDGSHSVIGTVLRQGYKLGEQVLRHAMVGVVDTVPDGDQGSSGADADDEDGGDEN
>NC_015576.1|WP_013827282.1|357446_358646_+|molecular-chaperone-DnaJ
MAQREWVEKDFYKELGVSSDASAEDVKRAARRLLAENHPDRNPGNKAAEDRYKAVSEAKEVLTDPAKRKEYDETRRLFAGGGFGRRFNGGGGFGGGGNFDRFSTGGDGSEFNLNDLFGAAGQTGGANIGDLFGGLFGRGAQQRPSRPRRGNDLETDSELSFLEATKGVEMPLRLTSAAPCTNCHGSGARPGTSPRVCSSCNGSGVINSNQGAFGFSEPCTDCRGSGSIIEHPCSECRGTGRAARTRTINVRIPPGVEDGQRIRLAGQGEAGLRGAPSGDLYVTVRVRPDKVFGRDGDDLTVTIPVSFSELALGTTLSVPTLDGKVGVRVPKGTADGRILRVRGRGVPKRGGGNGDLLVTVKVAVPPNLEGHAQDALEAYAAAERSSGFDPRAGWAGNRS

Crispr_ID: NC_015576_5

• CRISPR_ID: NC_015576_5
• CRISPR_location: 1423320-1423528
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers
• Cas_protein_info: DinG

Consensus repeat of NC_015576_5

Consensus_repeat	Method
CTCGCCTCCGCCAACCCTTCGGGCCAACTCCGGCGAGCCTCGCTGAACCGC	CRISPRCasFinder

spacers of NC_015576_5

>5.1|1423371|107|NC_015576|CRISPRCasFinder
GGTGCCTGTGCGGCGGTCCCAGCTTCGTCTCGCCTCCGCCAACCCTTCGGGCCAACTCCGGCGAGCCTCGCTGAACCGCGGTGCCTGTGCGGCGGTCCCAGCTTCGC

CRISPR arrays and Neighbor proteins around NC_015576_5

CRISPR arrays

The CRISPR arrays of NC_015576_5

>merge|NC_015576|5|1423320-1423528|CRISPRCasFinder
CTCGCCTCCGCCGACCCTTCGGGCCAACTCCGGCGAGCCTCGCTGAACCGCGGTGCCTGTGCGGCGGTCCCAGCTTCGTCTCGCCTCCGCCAACCCTTCGGGCCAACTCCGGCGAGCCTCGCTGAACCGCGGTGCCTGTGCGGCGGTCCCAGCTTCGCCTCGCCTCCGCCGACCCTTCGGGCCAACTCCGGCGAGCCTCGCTGAACCGC

>NC_015576|5|5|1423320-1423528|CRISPRCasFinder
CTCGCCTCCGCCGACCCTTCGGGCCAACTCCGGCGAGCCTCGCTGAACCGC	GGTGCCTGTGCGGCGGTCCCAGCTTCGTCTCGCCTCCGCCAACCCTTCGGGCCAACTCCGGCGAGCCTCGCTGAACCGCGGTGCCTGTGCGGCGGTCCCAGCTTCGC
CTCGCCTCCGCCGACCCTTCGGGCCAACTCCGGCGAGCCTCGCTGAACCGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015576.1|WP_041317480.1|1412295_1413900_-|HAMP-domain-containing-protein	unknown	unknown	gnl|CDD|143636
NC_015576.1|WP_013828276.1|1432473_1433070_+|DUF2017-domain-containing-protein	unknown	unknown	gnl|CDD|378185
NC_015576.1|WP_049793006.1|1430749_1432018_-|nicotinate-phosphoribosyltransferase	unknown	unknown	gnl|CDD|236426
NC_015576.1|WP_013828268.1|1423545_1426125_+|alpha-glucan-family-phosphorylase	unknown	unknown	gnl|CDD|340852
NC_015576.1|WP_013828263.1|1416071_1416566_-|methylmalonyl-CoA-epimerase	unknown	unknown	gnl|CDD|319912
NC_015576.1|WP_013828269.1|1426204_1427644_-|neutral-zinc-metallopeptidase	unknown	unknown	gnl|CDD|225203
NC_015576.1|WP_041317485.1|1429818_1430085_+|YdeI/OmpD-associated-family-protein	unknown	unknown	gnl|CDD|379149
NC_015576.1|WP_041317488.1|1430370_1430748_+|type-II-toxin-antitoxin-system-VapC-family-toxin	unknown	unknown	gnl|CDD|350221
NC_015576.1|WP_013828261.1|1413946_1414618_+|endonuclease-NucS	unknown	unknown	gnl|CDD|235114
NC_015576.1|WP_041317491.1|1432127_1432442_+|ATP-dependent-Clp-protease-adapter-ClpS	unknown	unknown	gnl|CDD|178809
NC_015576.1|WP_013828264.1|1416648_1417830_+|acetyl-CoA-C-acetyltransferase	unknown	unknown	gnl|CDD|180261
NC_015576.1|WP_013828265.1|1417976_1418870_+|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|225660
NC_015576.1|WP_013828262.1|1414672_1415767_+|NADH:flavin-oxidoreductase	unknown	unknown	gnl|CDD|240095
NC_015576.1|WP_013828277.1|1433066_1434155_+|P1-family-peptidase	unknown	unknown	gnl|CDD|239070
NC_015576.1|WP_013828267.1|1421155_1423201_-|DUF3416-domain-containing-protein	unknown	unknown	gnl|CDD|200482
NC_015576.1|WP_013828259.1|1411014_1412289_+|glutaminase-A	unknown	unknown	gnl|CDD|377427
NC_015576.1|WP_041319674.1|1427664_1429758_-|ATP-dependent-DNA-helicase	DinG	COG1199_DinG_CAS-IV-A	gnl|CDD|224120
NC_015576.1|WP_013828272.1|1430131_1430374_+|hypothetical-protein	unknown	unknown	gnl|CDD|226679
NC_015576.1|WP_013828258.1|1409414_1410920_-|DNA-3-methyladenine-glycosylase-2-family-protein	unknown	unknown	gnl|CDD|223200
NC_015576.1|WP_013828266.1|1418927_1421150_-|1,4-alpha-glucan-branching-protein-GlgB	unknown	unknown	gnl|CDD|235445

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_015576.1|WP_041319674.1|1427664_1429758_-|ATP-dependent-DNA-helicase	DinG	COG1199_DinG_CAS-IV-A	6.6e-133	439.0	0.1

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015576.1|WP_041317480.1|1412295_1413900_-|HAMP-domain-containing-protein	gnl|CDD|143636	cd07302, CHD, cyclase homology domain. Catalytic domains of the mononucleotidyl cyclases (MNC's), also called cyclase homology domains (CHDs), are part of the class III nucleotidyl cyclases. This class includes eukaryotic and prokaryotic adenylate cyclases (AC's) and guanylate cyclases (GC's). They seem to share a common catalytic mechanism in their requirement for two magnesium ions to bind the polyphosphate moiety of the nucleotide.	1.49682e-38
NC_015576.1|WP_013828276.1|1432473_1433070_+|DUF2017-domain-containing-protein	gnl|CDD|378185	pfam09438, DUF2017, Domain of unknown function (DUF2017). This is an alpha-helical domain found in gene neighborhoods that contain genes encoding ubiquitin, cysteine synthases and JAB peptidases.	9.4951e-72
NC_015576.1|WP_049793006.1|1430749_1432018_-|nicotinate-phosphoribosyltransferase	gnl|CDD|236426	PRK09243, PRK09243, nicotinate phosphoribosyltransferase; Validated.	0
NC_015576.1|WP_013828268.1|1423545_1426125_+|alpha-glucan-family-phosphorylase	gnl|CDD|340852	cd04299, GT35_Glycogen_Phosphorylase-like, proteins similar to glycogen phosphorylase. This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important allosteric enzymes in carbohydrate metabolism.	0
NC_015576.1|WP_013828263.1|1416071_1416566_-|methylmalonyl-CoA-epimerase	gnl|CDD|319912	cd07249, MMCE, Methylmalonyl-CoA epimerase (MMCE). MMCE, also called methylmalonyl-CoA racemase (EC 5.1.99.1) interconverts (2R)-methylmalonyl-CoA and (2S)-methylmalonyl-CoA. MMCE has been found in bacteria, archaea, and in animals. In eukaryotes, MMCE is an essential enzyme in a pathway that converts propionyl-CoA to succinyl-CoA, and is important in the breakdown of odd-chain length fatty acids, branched-chain amino acids, and other metabolites. In bacteria, MMCE participates in the reverse pathway for propionate fermentation, glyoxylate regeneration, and the biosynthesis of polyketide antibiotics. MMCE is closely related to glyoxalase I and type I extradiol dioxygenases.	4.34367e-54
NC_015576.1|WP_013828269.1|1426204_1427644_-|neutral-zinc-metallopeptidase	gnl|CDD|225203	COG2321, COG2321, Predicted metalloprotease [General function prediction only].	1.19694e-22
NC_015576.1|WP_041317485.1|1429818_1430085_+|YdeI/OmpD-associated-family-protein	gnl|CDD|379149	pfam13376, OmdA, Bacteriocin-protection, YdeI or OmpD-Associated. This is a family of archaeal and bacterial proteins predicted to be periplasmic. YdeI is important for resistance to polymyxin B in broth and for bacterial survival in mice upon oral, but not intraperitoneal inoculation, suggesting a role for YdeI in the gastrointestinal tract of mice. Production of the ydeI gene is regulated by the Rcs (regulator of capsule synthesis) phospho-relay system pathway independently of RcsA, and additionally transcription of the protein is regulated by the stationary-phase sigma factor, RpoS (sigma-S). YdeI confers protection against cationic AMPs (Antimicrobial peptides) or bacteriocins in conjunction with the general porin Omp, thus justifying its name of OmdA, for OmpD-Associated protein.	1.8025e-16
NC_015576.1|WP_041317488.1|1430370_1430748_+|type-II-toxin-antitoxin-system-VapC-family-toxin	gnl|CDD|350221	cd09873, PIN_Pae0151-like, VapC-like PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs. Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of the Pyrobaculum aerophilum proteins, Pae0151 and Pae2754, and homologs are included in this subfamily. They are similar to the PIN domains of the Mycobacterium tuberculosis VapC and Neisseria gonorrhoeae FitB toxins of the prokaryotic toxin/antitoxin operons, VapBC and FitAB, respectively, which are believed to be involved in growth inhibition by regulating translation. These toxins are nearly always co-expressed with an antitoxin, a cognate protein inhibitor, forming an inert protein complex. Disassociation of the protein complex activates the ribonuclease activity of the toxin by an, as yet undefined mechanism. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	7.90466e-22
NC_015576.1|WP_013828261.1|1413946_1414618_+|endonuclease-NucS	gnl|CDD|235114	PRK03298, PRK03298, endonuclease NucS.	8.84531e-178
NC_015576.1|WP_041317491.1|1432127_1432442_+|ATP-dependent-Clp-protease-adapter-ClpS	gnl|CDD|178809	PRK00033, clpS, ATP-dependent Clp protease adaptor protein ClpS; Reviewed.	5.05582e-41
NC_015576.1|WP_013828264.1|1416648_1417830_+|acetyl-CoA-C-acetyltransferase	gnl|CDD|180261	PRK05790, PRK05790, putative acyltransferase; Provisional.	0
NC_015576.1|WP_013828265.1|1417976_1418870_+|tetratricopeptide-repeat-protein	gnl|CDD|225660	COG3118, COG3118, Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones].	2.88799e-77
NC_015576.1|WP_013828262.1|1414672_1415767_+|NADH:flavin-oxidoreductase	gnl|CDD|240095	cd04747, OYE_like_5_FMN, Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as electron acceptors in the catalytic reaction. Other members of OYE family include trimethylamine dehydrogenase, 2,4-dienoyl-CoA reductase, enoate reductase, pentaerythriol tetranitrate reductase, xenobiotic reductase, and morphinone reductase.	0
NC_015576.1|WP_013828277.1|1433066_1434155_+|P1-family-peptidase	gnl|CDD|239070	cd02252, nylC_like, nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of highly-polymerized 6-aminohexanoate oligomers. Together with other nylon degradation enzymes, such as 6-aminohexanoate cyclic dimer hydrolase (EI) and 6-aminohexanoate dimer hydrolase (EII), EIII plays a role in the detoxification and biological removal of the synthetic by-products of nylon manufacture. EIII shows sequence similarity to L-aminopeptidase D-amidase/D-esterase (DmpA), an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. Like DmpA, EIII undergoes autocatalytic cleavage in front of a nucleophile to form a heterodimer. DmpA shows similarity in catalytic mechanism to N-terminal nucleophile (Ntn) hydrolases, which are enzymes that catalyze the cleavage of amide bonds through the nucleophilic attack of the side chain of an N-terminal serine, threonine, or cysteine.	1.34418e-94
NC_015576.1|WP_013828267.1|1421155_1423201_-|DUF3416-domain-containing-protein	gnl|CDD|200482	cd11344, AmyAc_GlgE_like, Alpha amylase catalytic domain found in GlgE-like proteins. GlgE is a (1,4)-a-D-glucan:phosphate a-D-maltosyltransferase, involved in a-glucan biosynthesis in bacteria. It is also an anti-tuberculosis drug target. GlgE isoform I from Streptomyces coelicolor has the same catalytic and very similar kinetic properties to GlgE from Mycobacterium tuberculosis. GlgE from Streptomyces coelicolor forms a homodimer with each subunit comprising five domains (A, B, C, N, and S) and 2 inserts. Domain A is a catalytic alpha-amylase-type domain that along with domain N, which has a beta-sandwich fold and forms the core of the dimer interface, binds cyclodextrins. Domain A, B, and the 2 inserts define a well conserved donor pocket that binds maltose. Cyclodextrins competitively inhibit the binding of maltooligosaccharides to the S. coelicolor enzyme, indicating that the hydrophobic patch overlaps with the acceptor binding site. This is not the case in M. tuberculosis GlgE because cyclodextrins do not inhibit this enzyme, despite acceptor length specificity being conserved. Domain C is hypothesized to help stabilize domain A and could be involved in substrate binding. Domain S is a helix bundle that is inserted within the N domain and it plays a role in the dimer interface and interacts directly with domain B. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	0
NC_015576.1|WP_013828259.1|1411014_1412289_+|glutaminase-A	gnl|CDD|377427	pfam04960, Glutaminase, Glutaminase. This family of enzymes deaminates glutamine to glutamate EC:3.5.1.2.	1.01854e-165
NC_015576.1|WP_041319674.1|1427664_1429758_-|ATP-dependent-DNA-helicase	gnl|CDD|224120	COG1199, DinG, Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair].	1.41141e-143
NC_015576.1|WP_013828272.1|1430131_1430374_+|hypothetical-protein	gnl|CDD|226679	COG4226, HicB, Predicted nuclease of the RNAse H fold, HicB family [General function prediction only].	8.19376e-05
NC_015576.1|WP_013828258.1|1409414_1410920_-|DNA-3-methyladenine-glycosylase-2-family-protein	gnl|CDD|223200	COG0122, AlkA, 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair].	1.37552e-61
NC_015576.1|WP_013828266.1|1418927_1421150_-|1,4-alpha-glucan-branching-protein-GlgB	gnl|CDD|235445	PRK05402, PRK05402, 1,4-alpha-glucan branching protein GlgB.	0

Protein sequences

>NC_015576.1|WP_013828267.1|1421155_1423201_-|DUF3416-domain-containing-protein
MPGRVEIDDVEPVISCGRYPAKAVVGETVPVKATVWREGHDAVAATLVVSYLGRRYPHPGESAGAPPVAGAAPLHIPMHTGFDDYVFHAAFTPDSVGLWAFRVEGWGDPLQSWRNAVTAKLEAGQGETELSNDLLVGADLFDRAAAGIPPAQRRPVQEAAAALRAPGDPVARAAPALSTEVEELLAGHPLRELVTRGENHQVWVDRPLARRGAWYEMFPRSTGGWDTDGNPVHGTFATAAAALPRIAAMGFDVVYLPPIHPIGHVHRKGRNNSTTAEPGDVGSPWAIGSAEGGHDAVHPALGTIDDFDDFVAAAHRLDLEVALDLALQCAPDHPWASQHREWFTELPDGTIAYAENPPKKYQDIYPLNFDNDPAGLYAEVLRVVRFWMVHGVKVFRVDNPHTKPPDFWIWLIAAVKNIDPDVLFLSEAFTPPARQYGLAKLGFTQSYTYFTWRTSKSELTEFGQQIAELADYRRPNLFVNTPDILHASLQSGGPGMFAIRAVLAATLGPTWGVYSGFELFEDRALREGSEEYLDSEKYQLRPRDFAAAVAEGRSLEPFIARLNEIRRMHPALSQLRTVHFHSVDNDALLAYSKFDPDSGDTVLVVVNLNPFVPEHATLRLDMWALGMEDYQRFWVRDQISGEDYHWGRENWVRLDPARAVAHIVNMPPINAQARTALLRRR
>NC_015576.1|WP_013828266.1|1418927_1421150_-|1,4-alpha-glucan-branching-protein-GlgB
MARQLAPAAADLTRLLAGEHHDPHAILGAHEYGEVTVVRVLRPRARRAVVVVGTDRFPMRHLGSGLFAVALPLTGLADYRLELHYPDAAAFAEPTGIHTVADGYRFAPTLGEVDLHLFAEGRHERLWDVLGAHRRTFTTAGGDVSGVSFAVWAPNATGVGLIGDFNGWDSNDAPLRALGSSGVWEVFWPDFPPDGLYKFRIHGADGSVSDRADPFAFATEVPPRTASRVTHSDYRWGDADWMTQRAGRDPVAEPMSIYEVHLGSWRPGLSYRQLAVELTEYVVQHGFTHVELLPVAEHPFGGSWGYQVTSYYAPTARFGTPDDFRALVDALHRAGIGVIVDWVPAHFPKDAWALGRFDGTPLYEHADPRRGEQLDWGTYVFDFGRPEVRNFLVANALYWLTEFHVDGLRVDAVASMLYLDYSRPEGGWTPNIHGGRENLEAVQFLQELNATAHRVAPGIVTIAEESTSWPGVTRDTSLGGLGFSMKWNMGWMHDTLSYLGHDPVHRSYHHHEMTFSMLYAYSENFVLPISHDEVVHGKGTLWTRMPGDDHAKAAGVRTLLAYQWAHPGKQLLFMGQEFGQRGEWCNERGVDWFQLDPHTEPDGYSPGILRLVGDINAHYRALPALWSQDGDPRGYSWIDANDSTNNVLSFLRYGADGSMLACVFNFSGVEHADYHLGLPRAGRWREVLNTDAVGYRGSGAGNLGGVAATDDPWHGRPASAVLLLPALSALWLAPSSPEQT
>NC_015576.1|WP_013828265.1|1417976_1418870_+|tetratricopeptide-repeat-protein
MTRPRPPIGPALAGAVDLSGLKQPPGGAGGDGSAPPGATEITEANFEDEVLVRSNQVPVVVLLWSPRSEACIKLADTLGALATSDGGTWSLATVNVDVAPRVAQVFGVEAVPTVVALAAGQPITSFQGVQPPDQLRRWVDSLLSATAGKLSGGVETEQPEQVDPALARARDQLDAGDFAAARDSYQELLAADPDHVEAKAALRQLTFLERATGRQPDAPALADAAPDDIEAAFAAADVQILNQDVTAAFDRLIALVRRTSGDERSTVRARLVELFELFDPADPEVVAGRRNLANALY
>NC_015576.1|WP_013828264.1|1416648_1417830_+|acetyl-CoA-C-acetyltransferase
MTTSVIVAGARTPIGKLMGSLKDFSGSDLGAIAIAGALEKAGVPASLVEYVIMGQVLTAGAGQMPARQASVGAGIGWDVPALSINKMCLSGIDSIALADQLIRAGEFDVVVAGGQESMTKAPHLLMDSRSGYKYGDVTVLDHLAYDGLHDVFTDQPMGALTEQRNDADKFTRAEQDECAAESHRRAAAAWKDGVFADEVVPVKIPQRKGDPLEFTEDEGIRANTTAESLAGLKPAFRKDGTITAGSSSQISDGAAAVVVMSKAKAQQLGLDWLCEIGAHGVVAGPDSTLQSQPANAIKKAIAREGISVDQLGVVEINEAFAAVSLASTRELGVNPDVVNVHGGAIAVGHPIGMSGARITLHAALELKRRGSGYAVAALCGAGGQGDALILRTG
>NC_015576.1|WP_013828263.1|1416071_1416566_-|methylmalonyl-CoA-epimerase
MTTDSVTDPFEVRSALASALVTAIDHVGIAVPDLEAAKKWYHDQLGMIVLHEEVNDEQGIVEAMLAVRGAPVGSAQLQLMAPIDESSTIAKFLDKRGPGLQQLAYRTSDIDALSQRLRDQGVRLLYDAPRRGTSNSRINFIHPKDAGGVLVELVEPAGDTAAVH
>NC_015576.1|WP_013828262.1|1414672_1415767_+|NADH:flavin-oxidoreductase
MAVEDLFQPLTVRSLTVPNRFAMAPMTRRASPSGVPGTDVAEYYRRRAAGGVGLIITEGIRLPDPAAGYPFSVPTIAGDEVLAGWRRVVDGVHAEGATIAAQLWHQGVERDDSDGVEPVGPSGINGRGEPRGRALRTDELPEVAQLFANSAATARDIGFDAVEIHGAHGYLLDEFLWERTNRRTDGYGGSLAGRTRFPAEVVAAVRAAVGPDYPIIFRFSQWKGTDYTAWIADDPAQLADLLAPLIDAGVDVLHPSTRRHYLPAFPDDDPELSLAGWSKKVSGAPVITVGSVGLETQFRSEKRGEVIQPAPVDRLVEQFDAGEFDVVAIGRALLADPTWVNRLRRGELDRFAGYDAAVALAALA
>NC_015576.1|WP_013828261.1|1413946_1414618_+|endonuclease-NucS
MRLVIAQCTVDYVGRLTAHLPSARRLLLLKADGSVSVHADDRAYKPLNWMSPPCRLTEERAGEFAVWVVTNKTGDQLRITIEEIEHDSSHELGVDPGLVKDGVEAQLQALLAEHVELLGEGYSLVRREYMTAIGPVDLLCRDEQGRSVAVEIKRRGEIDGVEQLTRYLELLNRDSLLAPVSGVFAAQQIKPQARTLATDRGIRCVTLDYDAMRGMNSDEYRLF
>NC_015576.1|WP_041317480.1|1412295_1413900_-|HAMP-domain-containing-protein
MKAPKTTAQRMGRVLELLTRQTDRLPETPEYGSWLLGRVSESQYLRRIRIQFILTVVIVGTNLIGIGVEALLLAVAFPSPSVFFDAPGWLTYGVVPAYIVLALIFGTYWITRRTIKKLRWAIREQQPTRVDERNAFLAPWRVAQVVLALWGVAAMLFTVLYGMADNYFIPIVAFTVGVCGIQVATACYLCTEFALRPVAAQALAAGPPPRRFFSGIMGRTMMVWLLSSGVPVLGIALTAIFALVLKNLSMTQFGVAVLVVAVATAVFGFLLMWILSWLTAAPVRVVRAALRRVEQGNLGADLVVFDGTELGELQSGFNAMVHGLRERERVRDLFGRHVGREVAAAAERDRIQLGGEERHVAVLFVDIIGSTQIVTAKPATEVVTLLNRFFAVVVDEVDRHRGLINKFEGDASLAIFGAPNHLDQPEDEALAAGRAILSRLADEVPEIRAGIGVAAGQVVAGNVGAKERFEYTVIGEPVNEAARLSELAKIRELQLLTTARTLRAASISEQAHWVLGDSVVLRGYDQPTVLAGPL
>NC_015576.1|WP_013828259.1|1411014_1412289_+|glutaminase-A
MAALVQRYLDGILAEHAEVNVGALASYIPELARVDPTGFGLSLSSSDGYVYESGDAEAQFTMQSISKPFTYALALDQLGHADVDARIGVEPSGEGFNRISVDQVTQVPKNPMINAGAIVACSLIPGATADDRFALVREFYSACAGRGLDFDEDVYRSEKASGSRNRGIAYLLDSFGALDADPDDALDVYIRQCSLKVTSTDLARMAATLARGGYNPLTGRQVTDAAVVRRTLSVMVTCGMYDAAGEWVSAVGMPAKSGVGGGIVAVLPGQLGIGVYSPRIDAKGNSVRGVLVCRSLSQQLGLHFLTVSSEAHSAIRGMYTPRPGVRVYEVHGDLLFAGAEQVARTATGDCGDFGVAILDVSRLHAISDPARALLAGLAHELQSLGKRGLLVDPGGALTSDPATRGTLVFATVDDALAASEKWVT
>NC_015576.1|WP_013828258.1|1409414_1410920_-|DNA-3-methyladenine-glycosylase-2-family-protein
MHDDFDRCYRAVQSSDARFDGWFYTAVLTTRIYCRPSCPVRPPLPRNVRFYPTAAAAQRAGFRACKRCRPDAAPGSPEWNVRGDIVGRAMRLVADGTVDREGVTGLAGHLGYSTRQLQRLLHNEVGAGPLALARAQRAQTARILIETTDLPLSDIAFAAGFASIRQFNDTVRAVWATTPTALRQHAAARFKAESDRRPPSPGGLSLRLPVRTPFAFEGVFGHLAACAVPGCEEVRDGAYRRTLRLPHGNGIVSLTPAPDHVRCELVLDDFRDLTAAITRCRRLLDLDADPEAVVEALTDDPELAPLVAKAPGQRIPRTVDEAELAVRAVLSQQVSVKAARTHTRRLLLGHGEPIVDPSGGLTHVFPSVERLADIDADRLALPRARRRTLLALVAGLADGSISLGAGCDWGRARKSLLELPGVGAWTAELIAMRGLGDPDAFPATDLGVRVAVRRLGLPEQPRALTERSLRWRPWRSYATQHLWTALDHAVNDWPRTSKEIA
>NC_015576.1|WP_013828268.1|1423545_1426125_+|alpha-glucan-family-phosphorylase
MKALRRFTVRAHLPDRLRALEQLSMNLRWSWDQPTQELFASIDPELWAGCGRDPVALLGAVSPARLDELAADEAFTGRLDTLSADLDEYLTQPRWYQQQQDAGAALPAAIAYFSMEFGVAEALPNYSGGLGILAGDHLKSASDLGVPLIAVGLYYRSGYFRQSLTADGWQRETYPSLDPQGLPLRLLADAAGNPALIEVALPGAGRLRARIWVAQVGRVPLLLLDSDIGENEHQLRGVTDRLYGGDQEHRIRQEILAGIGGVRAIRAFTELSGTPAPEVFHMNEGHAGFLGIERIRELIAEQHLEFDTALAVVRSATVFTTHTPVPAGIDRFRIDMVRRYFDGNALAGGVPVERILELGAEPDPDTFNMAHMGLRLAQRANGVSRLHGRVSRAMFDGLWPGFDRDEVPIGSITNGVHAPSWAAAPWLQLGRDLATADSFSEPAAWERLQQVDPVALWSIRSQLRSVLVDEVRFRLLRSGLDRGASEAELGWIATAFDPDVLTIGFARRVPTYKRLTLMLRDPDRLEQLLLDEQRPVQLIVAGKSHPADDGGKALIQQVVRFADRPEVRHRIAFLPDYDMSMARRLYAGCDVWLNNPLRPLEACGTSGMKSALNGGLNLSIRDGWWDEWFDGENGWAIPTADGVADENRRDDLEAAALYDLLAQSVVPKFYDRDERGVPPRWIEMVHHTLQTLGPKVLASRMVRDYVEQCYAPAAQSLRRTREPVDGVPYGAARQLADYRTRAERAWPRIEITDVDSTGLPDTPQLGSELTLTATVRLAGLAPDEVTVQAVLGRLDSDDTLLDPATVVMAHERTGADGTDVFSTTTALPVAGAVGYTVRVLPSHPLLSGDAELGLITLAT
>NC_015576.1|WP_013828269.1|1426204_1427644_-|neutral-zinc-metallopeptidase
MRRRHRALATACTLVLLLSGCARMLEGTPVSIFADPFRVGGLQAVDGPTGLRPDAPPPSREVEGTDGGRIDQLAAQSVSDLEAFWTTSFPNTFDGDFEPVRALLSWDPGQLRGTFCKSRTFLLINAAYCYLDDTIGWDRRLLLPALRSIYGDMAITMVLAHEYGHAIARAAGITKRRQTPTLVAEQQADCLAGVYLRWVAHGDSPRFTLSTGDGLNAVLAAMLALRDPLLNPGETVGDNEHGSAFERISAFQFGFTDGAGSCKAIDAQEIEQRRGELPVQLQQNETGEVPVSEDSVRVIVDAMNIAFDPDKPPQLTFDAAAASSCTDARPSPPASYCPATNTIAVDLPALQAMGTPSKDQKLATLSGDNTAYSVLVSRYLQAVQIEHGGLVLDNAAAALRTACLTGVATTRLSQGVTTSNGSTITLTAGDLDEAVAGLLTNGLAAGDINGESVPAGFSRIDAYRTGVLGDFDRCLQRFP
>NC_015576.1|WP_041319674.1|1427664_1429758_-|ATP-dependent-DNA-helicase
MADASVPELLATAVAALGGSQRDGQVRMAEAVAHAFDTGEHLAVQAGTGTGKSLAYLVPAIARAVADDHPVVVSTATIALQRQLVDRDLPRLADALEDVLPRRPTFALLKGRRNYLCLNKIHSGTGDDSGEAPQEELFEPFAASALGRDVQRLTAWADDTATGDRDDLKPGVPERSWAQVSVSARECLGATRCQFGTDCFAEQARAVAGEADIVVTNHALLAIDAISDTTVLPEHELLVVDEAHELVDRVTSVATAELTAAALSVAVRRVTRLVSPGLVQRLDAASLTFGSAIHDGTPGRMDYLDDELATYLAALRDAAGAVRSAIDTAPSDPRAATARKEAVAALAEIADTAARVLTSFEPAIPARTDVVWLSHEDNRGSVRPVLRVAPLSVAGLLHDRLFARTTTVLTSATLTVGGSFDAMAGAWGLTGGSVPGGSARLDGGEPKLGPPHGRRGSARLDEGEPKLGPPHRPDNGWRGLDVGSPFQHAKAGILYVAAHLPPPGRDGTGTDAQLDEIAELIAAAGGRTLGLFSSMRAARAAAEAMRERLDTPLLCQGEDTTGALVEQFAADADTSLFGTLSLWQGVDVPGPSLSLVLIDRIPFPRPDDPLLTARQRAVSARGGNGFMAVAASHAALLLAQGAGRLLRGVDDRGVVAVLDSRMATARYAGYLRASLPPFWATTDTDKVRLALRRLRGG
>NC_015576.1|WP_041317485.1|1429818_1430085_+|YdeI/OmpD-associated-family-protein
MTSQRLPGGAVHELPADLRDGLLVSSTALAAWESITPLARNEFICWVEDAKQQATRERRIRRTREELEEGKRRPCCWPGCKHRERTGS
>NC_015576.1|WP_013828272.1|1430131_1430374_+|hypothetical-protein
MSKVMHIRDVPDEVHAALVEAAAAQGLSLTRYLQRELEHLAKRAQVVRHNAAVIRRTQRAVEGRADRDTILSVLHEGRGE
>NC_015576.1|WP_041317488.1|1430370_1430748_+|type-II-toxin-antitoxin-system-VapC-family-toxin
MKIVDAGVVVELLVGGLDPQRLGHEELAAPHLVDSEVTQVLRGLVRRGVLGAKQGDLAMDGFMRLTLTRFPADWLRPRIWELRDNLSAYDATYVALAELVDATALLTTDARLANAPGPRCRVDLL
>NC_015576.1|WP_049793006.1|1430749_1432018_-|nicotinate-phosphoribosyltransferase
MLAAALRDGTAGRRTGFELFARRLPEGRRYGVVAGTDRFLGALTSFGFDDADLGLLSEFLDPDTVSYLRDFRFRGDVDGYAEGELYFAGSPVLSVRASFAECIVLETLLLSIFNHDTAVASAAARMVSAADGRPLIEMGSRRTHEQAAVAAARAAYLAGFAGTSNLEAHRSFGVPVLGTSAHAFTLLHAGSDVADGDGELAAFRAQVAALGVGTTLLVDTYDVTTGVANAVEAAGSRLGAVRIDSGELAVLAHQVREQLDRLGATATRIVVSGDLDEFAIAALRAAPVDSYGVGTAVVTGSGAPAAGFVYKLVEVDGVAVHKRSADKTSAGGCKQALRTFRPSGTLVEEVVHPAGRPPEVSGPHRLVTVPLVRGGDVVTDTGPAALAAARDRVASGLLSLPWEGLKLARGEPAVSIRLISSR
>NC_015576.1|WP_041317491.1|1432127_1432442_+|ATP-dependent-Clp-protease-adapter-ClpS
MATSAATSAPVKPQGTGQRHADPVEDTASPWVTIVWDDPVNLMTYVTYVFQKLFGYSEPHATKLMLQVHHEGKAVVSAGSRESMEVDVSKLHAAGLWATMQQDR
>NC_015576.1|WP_013828276.1|1432473_1433070_+|DUF2017-domain-containing-protein
MHKWKRVETDGGPRFRSALALHEAALLRNLVGSIIGMLEARESASPPDELEQITGMKTGNTQPPEDATTRRLLPDFYRADGGGAAADGSALDAEGLNAALRSLHEPEIIDAKRGAAQQVLDTLPERGGRFELTEEQANAWIAAVNDIRLALGTMLQIGPNGPDRLPPGDPRAGQLNVYQWLTVLQEYLVVALMGRPGR
>NC_015576.1|WP_013828277.1|1433066_1434155_+|P1-family-peptidase
MTDTGSITDVAGIRVGHHHRLDPDATLGSGWASGVTVVLAPPGTVGAVDSRGGAPGSRETDLLDPANSVRWVDAVVLAGGSAYGLASADGVMTWLEEQGRGVALDGGVVPIVPAAVIFDLPVGGWDRRPTAEFGYAAAAAAAGPDGARPATGCVGAGVGARAGVFKGGVGTASITLELGEHGEHSVTVGALVVVNPSGEVIDATTGLPWSAYLVEEFGLTAPPSEELAVLAGLEPKSRSLNTTIAVVATDAALSPAGCRRMAIAAQDGLSRTIRPSHTPVDGDTVFALATGAVEVPELADTPAAMSPETGLVAEVGAAAADCLARAVLAGVLAADPVAGIPTYGGTLPGAFGSKPAGSTGRS

Crispr_ID: NC_015576_6

• CRISPR_ID: NC_015576_6
• CRISPR_location: 1428375-1428454
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_015576_6

Consensus_repeat	Method
CGTCGAGCCTCGCTGAACCGCGG	CRISPRCasFinder

spacers of NC_015576_6

>6.1|1428398|34|NC_015576|CRISPRCasFinder
CGCCCATGCGGCGGTCCCAGCTTCGGCTCTCCTC

CRISPR arrays and Neighbor proteins around NC_015576_6

CRISPR arrays

The CRISPR arrays of NC_015576_6

>merge|NC_015576|6|1428375-1428454|CRISPRCasFinder
CGTCGAGCCTCGCTGAACCGCGGCGCCCATGCGGCGGTCCCAGCTTCGGCTCTCCTCCGTCGAGCCTCGCTGAACCGCCG

>NC_015576|6|6|1428375-1428454|CRISPRCasFinder
CGTCGAGCCTCGCTGAACCGCGG	CGCCCATGCGGCGGTCCCAGCTTCGGCTCTCCTC
CGTCGAGCCTCGCTGAACCGCCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015576.1|WP_041317480.1|1412295_1413900_-|HAMP-domain-containing-protein	unknown	unknown	gnl|CDD|143636
NC_015576.1|WP_013828276.1|1432473_1433070_+|DUF2017-domain-containing-protein	unknown	unknown	gnl|CDD|378185
NC_015576.1|WP_049793006.1|1430749_1432018_-|nicotinate-phosphoribosyltransferase	unknown	unknown	gnl|CDD|236426
NC_015576.1|WP_013828268.1|1423545_1426125_+|alpha-glucan-family-phosphorylase	unknown	unknown	gnl|CDD|340852
NC_015576.1|WP_013828263.1|1416071_1416566_-|methylmalonyl-CoA-epimerase	unknown	unknown	gnl|CDD|319912
NC_015576.1|WP_041317494.1|1434162_1434816_+|rhomboid-family-intramembrane-serine-protease	unknown	unknown	gnl|CDD|366759
NC_015576.1|WP_041317485.1|1429818_1430085_+|YdeI/OmpD-associated-family-protein	unknown	unknown	gnl|CDD|379149
NC_015576.1|WP_041317488.1|1430370_1430748_+|type-II-toxin-antitoxin-system-VapC-family-toxin	unknown	unknown	gnl|CDD|350221
NC_015576.1|WP_013828261.1|1413946_1414618_+|endonuclease-NucS	unknown	unknown	gnl|CDD|235114
NC_015576.1|WP_041317491.1|1432127_1432442_+|ATP-dependent-Clp-protease-adapter-ClpS	unknown	unknown	gnl|CDD|178809
NC_015576.1|WP_013828264.1|1416648_1417830_+|acetyl-CoA-C-acetyltransferase	unknown	unknown	gnl|CDD|180261
NC_015576.1|WP_013828265.1|1417976_1418870_+|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|225660
NC_015576.1|WP_013828280.1|1435698_1436475_+|MBL-fold-metallo-hydrolase	unknown	unknown	gnl|CDD|293802
NC_015576.1|WP_013828279.1|1434812_1435619_+|glutamate-racemase	unknown	unknown	gnl|CDD|234851
NC_015576.1|WP_013828277.1|1433066_1434155_+|P1-family-peptidase	unknown	unknown	gnl|CDD|239070
NC_015576.1|WP_013828267.1|1421155_1423201_-|DUF3416-domain-containing-protein	unknown	unknown	gnl|CDD|200482
NC_015576.1|WP_013828266.1|1418927_1421150_-|1,4-alpha-glucan-branching-protein-GlgB	unknown	unknown	gnl|CDD|235445
NC_015576.1|WP_013828272.1|1430131_1430374_+|hypothetical-protein	unknown	unknown	gnl|CDD|226679
NC_015576.1|WP_013828262.1|1414672_1415767_+|NADH:flavin-oxidoreductase	unknown	unknown	gnl|CDD|240095
NC_015576.1|WP_013828269.1|1426204_1427644_-|neutral-zinc-metallopeptidase	unknown	unknown	gnl|CDD|225203

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015576.1|WP_041317480.1|1412295_1413900_-|HAMP-domain-containing-protein	gnl|CDD|143636	cd07302, CHD, cyclase homology domain. Catalytic domains of the mononucleotidyl cyclases (MNC's), also called cyclase homology domains (CHDs), are part of the class III nucleotidyl cyclases. This class includes eukaryotic and prokaryotic adenylate cyclases (AC's) and guanylate cyclases (GC's). They seem to share a common catalytic mechanism in their requirement for two magnesium ions to bind the polyphosphate moiety of the nucleotide.	1.49682e-38
NC_015576.1|WP_013828276.1|1432473_1433070_+|DUF2017-domain-containing-protein	gnl|CDD|378185	pfam09438, DUF2017, Domain of unknown function (DUF2017). This is an alpha-helical domain found in gene neighborhoods that contain genes encoding ubiquitin, cysteine synthases and JAB peptidases.	9.4951e-72
NC_015576.1|WP_049793006.1|1430749_1432018_-|nicotinate-phosphoribosyltransferase	gnl|CDD|236426	PRK09243, PRK09243, nicotinate phosphoribosyltransferase; Validated.	0
NC_015576.1|WP_013828268.1|1423545_1426125_+|alpha-glucan-family-phosphorylase	gnl|CDD|340852	cd04299, GT35_Glycogen_Phosphorylase-like, proteins similar to glycogen phosphorylase. This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important allosteric enzymes in carbohydrate metabolism.	0
NC_015576.1|WP_013828263.1|1416071_1416566_-|methylmalonyl-CoA-epimerase	gnl|CDD|319912	cd07249, MMCE, Methylmalonyl-CoA epimerase (MMCE). MMCE, also called methylmalonyl-CoA racemase (EC 5.1.99.1) interconverts (2R)-methylmalonyl-CoA and (2S)-methylmalonyl-CoA. MMCE has been found in bacteria, archaea, and in animals. In eukaryotes, MMCE is an essential enzyme in a pathway that converts propionyl-CoA to succinyl-CoA, and is important in the breakdown of odd-chain length fatty acids, branched-chain amino acids, and other metabolites. In bacteria, MMCE participates in the reverse pathway for propionate fermentation, glyoxylate regeneration, and the biosynthesis of polyketide antibiotics. MMCE is closely related to glyoxalase I and type I extradiol dioxygenases.	4.34367e-54
NC_015576.1|WP_041317494.1|1434162_1434816_+|rhomboid-family-intramembrane-serine-protease	gnl|CDD|366759	pfam01694, Rhomboid, Rhomboid family. This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.	7.76566e-22
NC_015576.1|WP_041317485.1|1429818_1430085_+|YdeI/OmpD-associated-family-protein	gnl|CDD|379149	pfam13376, OmdA, Bacteriocin-protection, YdeI or OmpD-Associated. This is a family of archaeal and bacterial proteins predicted to be periplasmic. YdeI is important for resistance to polymyxin B in broth and for bacterial survival in mice upon oral, but not intraperitoneal inoculation, suggesting a role for YdeI in the gastrointestinal tract of mice. Production of the ydeI gene is regulated by the Rcs (regulator of capsule synthesis) phospho-relay system pathway independently of RcsA, and additionally transcription of the protein is regulated by the stationary-phase sigma factor, RpoS (sigma-S). YdeI confers protection against cationic AMPs (Antimicrobial peptides) or bacteriocins in conjunction with the general porin Omp, thus justifying its name of OmdA, for OmpD-Associated protein.	1.8025e-16
NC_015576.1|WP_041317488.1|1430370_1430748_+|type-II-toxin-antitoxin-system-VapC-family-toxin	gnl|CDD|350221	cd09873, PIN_Pae0151-like, VapC-like PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs. Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of the Pyrobaculum aerophilum proteins, Pae0151 and Pae2754, and homologs are included in this subfamily. They are similar to the PIN domains of the Mycobacterium tuberculosis VapC and Neisseria gonorrhoeae FitB toxins of the prokaryotic toxin/antitoxin operons, VapBC and FitAB, respectively, which are believed to be involved in growth inhibition by regulating translation. These toxins are nearly always co-expressed with an antitoxin, a cognate protein inhibitor, forming an inert protein complex. Disassociation of the protein complex activates the ribonuclease activity of the toxin by an, as yet undefined mechanism. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	7.90466e-22
NC_015576.1|WP_013828261.1|1413946_1414618_+|endonuclease-NucS	gnl|CDD|235114	PRK03298, PRK03298, endonuclease NucS.	8.84531e-178
NC_015576.1|WP_041317491.1|1432127_1432442_+|ATP-dependent-Clp-protease-adapter-ClpS	gnl|CDD|178809	PRK00033, clpS, ATP-dependent Clp protease adaptor protein ClpS; Reviewed.	5.05582e-41
NC_015576.1|WP_013828264.1|1416648_1417830_+|acetyl-CoA-C-acetyltransferase	gnl|CDD|180261	PRK05790, PRK05790, putative acyltransferase; Provisional.	0
NC_015576.1|WP_013828265.1|1417976_1418870_+|tetratricopeptide-repeat-protein	gnl|CDD|225660	COG3118, COG3118, Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones].	2.88799e-77
NC_015576.1|WP_013828280.1|1435698_1436475_+|MBL-fold-metallo-hydrolase	gnl|CDD|293802	cd07716, RNaseZ_short-form-like_MBL-fold, uncharacterized bacterial subgroup of Ribonuclease Z, short form; MBL-fold metallo-hydrolase domain. The tRNA maturase RNase Z (also known as tRNase Z or 3' tRNase) catalyzes the endonucleolytic removal of the 3' extension of the majority of tRNA precursors. Two forms of RNase Z exist in eukaryotes, one long (ELAC2) and one short form (ELAC1), the former may have resulted from a duplication of the shorter enzyme. Only the short form exists in bacteria. Members of this bacterial subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	1.55385e-72
NC_015576.1|WP_013828279.1|1434812_1435619_+|glutamate-racemase	gnl|CDD|234851	PRK00865, PRK00865, glutamate racemase; Provisional.	2.17792e-133
NC_015576.1|WP_013828277.1|1433066_1434155_+|P1-family-peptidase	gnl|CDD|239070	cd02252, nylC_like, nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of highly-polymerized 6-aminohexanoate oligomers. Together with other nylon degradation enzymes, such as 6-aminohexanoate cyclic dimer hydrolase (EI) and 6-aminohexanoate dimer hydrolase (EII), EIII plays a role in the detoxification and biological removal of the synthetic by-products of nylon manufacture. EIII shows sequence similarity to L-aminopeptidase D-amidase/D-esterase (DmpA), an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. Like DmpA, EIII undergoes autocatalytic cleavage in front of a nucleophile to form a heterodimer. DmpA shows similarity in catalytic mechanism to N-terminal nucleophile (Ntn) hydrolases, which are enzymes that catalyze the cleavage of amide bonds through the nucleophilic attack of the side chain of an N-terminal serine, threonine, or cysteine.	1.34418e-94
NC_015576.1|WP_013828267.1|1421155_1423201_-|DUF3416-domain-containing-protein	gnl|CDD|200482	cd11344, AmyAc_GlgE_like, Alpha amylase catalytic domain found in GlgE-like proteins. GlgE is a (1,4)-a-D-glucan:phosphate a-D-maltosyltransferase, involved in a-glucan biosynthesis in bacteria. It is also an anti-tuberculosis drug target. GlgE isoform I from Streptomyces coelicolor has the same catalytic and very similar kinetic properties to GlgE from Mycobacterium tuberculosis. GlgE from Streptomyces coelicolor forms a homodimer with each subunit comprising five domains (A, B, C, N, and S) and 2 inserts. Domain A is a catalytic alpha-amylase-type domain that along with domain N, which has a beta-sandwich fold and forms the core of the dimer interface, binds cyclodextrins. Domain A, B, and the 2 inserts define a well conserved donor pocket that binds maltose. Cyclodextrins competitively inhibit the binding of maltooligosaccharides to the S. coelicolor enzyme, indicating that the hydrophobic patch overlaps with the acceptor binding site. This is not the case in M. tuberculosis GlgE because cyclodextrins do not inhibit this enzyme, despite acceptor length specificity being conserved. Domain C is hypothesized to help stabilize domain A and could be involved in substrate binding. Domain S is a helix bundle that is inserted within the N domain and it plays a role in the dimer interface and interacts directly with domain B. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	0
NC_015576.1|WP_013828266.1|1418927_1421150_-|1,4-alpha-glucan-branching-protein-GlgB	gnl|CDD|235445	PRK05402, PRK05402, 1,4-alpha-glucan branching protein GlgB.	0
NC_015576.1|WP_013828272.1|1430131_1430374_+|hypothetical-protein	gnl|CDD|226679	COG4226, HicB, Predicted nuclease of the RNAse H fold, HicB family [General function prediction only].	8.19376e-05
NC_015576.1|WP_013828262.1|1414672_1415767_+|NADH:flavin-oxidoreductase	gnl|CDD|240095	cd04747, OYE_like_5_FMN, Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as electron acceptors in the catalytic reaction. Other members of OYE family include trimethylamine dehydrogenase, 2,4-dienoyl-CoA reductase, enoate reductase, pentaerythriol tetranitrate reductase, xenobiotic reductase, and morphinone reductase.	0
NC_015576.1|WP_013828269.1|1426204_1427644_-|neutral-zinc-metallopeptidase	gnl|CDD|225203	COG2321, COG2321, Predicted metalloprotease [General function prediction only].	1.19694e-22

Protein sequences

>NC_015576.1|WP_013828269.1|1426204_1427644_-|neutral-zinc-metallopeptidase
MRRRHRALATACTLVLLLSGCARMLEGTPVSIFADPFRVGGLQAVDGPTGLRPDAPPPSREVEGTDGGRIDQLAAQSVSDLEAFWTTSFPNTFDGDFEPVRALLSWDPGQLRGTFCKSRTFLLINAAYCYLDDTIGWDRRLLLPALRSIYGDMAITMVLAHEYGHAIARAAGITKRRQTPTLVAEQQADCLAGVYLRWVAHGDSPRFTLSTGDGLNAVLAAMLALRDPLLNPGETVGDNEHGSAFERISAFQFGFTDGAGSCKAIDAQEIEQRRGELPVQLQQNETGEVPVSEDSVRVIVDAMNIAFDPDKPPQLTFDAAAASSCTDARPSPPASYCPATNTIAVDLPALQAMGTPSKDQKLATLSGDNTAYSVLVSRYLQAVQIEHGGLVLDNAAAALRTACLTGVATTRLSQGVTTSNGSTITLTAGDLDEAVAGLLTNGLAAGDINGESVPAGFSRIDAYRTGVLGDFDRCLQRFP
>NC_015576.1|WP_013828268.1|1423545_1426125_+|alpha-glucan-family-phosphorylase
MKALRRFTVRAHLPDRLRALEQLSMNLRWSWDQPTQELFASIDPELWAGCGRDPVALLGAVSPARLDELAADEAFTGRLDTLSADLDEYLTQPRWYQQQQDAGAALPAAIAYFSMEFGVAEALPNYSGGLGILAGDHLKSASDLGVPLIAVGLYYRSGYFRQSLTADGWQRETYPSLDPQGLPLRLLADAAGNPALIEVALPGAGRLRARIWVAQVGRVPLLLLDSDIGENEHQLRGVTDRLYGGDQEHRIRQEILAGIGGVRAIRAFTELSGTPAPEVFHMNEGHAGFLGIERIRELIAEQHLEFDTALAVVRSATVFTTHTPVPAGIDRFRIDMVRRYFDGNALAGGVPVERILELGAEPDPDTFNMAHMGLRLAQRANGVSRLHGRVSRAMFDGLWPGFDRDEVPIGSITNGVHAPSWAAAPWLQLGRDLATADSFSEPAAWERLQQVDPVALWSIRSQLRSVLVDEVRFRLLRSGLDRGASEAELGWIATAFDPDVLTIGFARRVPTYKRLTLMLRDPDRLEQLLLDEQRPVQLIVAGKSHPADDGGKALIQQVVRFADRPEVRHRIAFLPDYDMSMARRLYAGCDVWLNNPLRPLEACGTSGMKSALNGGLNLSIRDGWWDEWFDGENGWAIPTADGVADENRRDDLEAAALYDLLAQSVVPKFYDRDERGVPPRWIEMVHHTLQTLGPKVLASRMVRDYVEQCYAPAAQSLRRTREPVDGVPYGAARQLADYRTRAERAWPRIEITDVDSTGLPDTPQLGSELTLTATVRLAGLAPDEVTVQAVLGRLDSDDTLLDPATVVMAHERTGADGTDVFSTTTALPVAGAVGYTVRVLPSHPLLSGDAELGLITLAT
>NC_015576.1|WP_013828267.1|1421155_1423201_-|DUF3416-domain-containing-protein
MPGRVEIDDVEPVISCGRYPAKAVVGETVPVKATVWREGHDAVAATLVVSYLGRRYPHPGESAGAPPVAGAAPLHIPMHTGFDDYVFHAAFTPDSVGLWAFRVEGWGDPLQSWRNAVTAKLEAGQGETELSNDLLVGADLFDRAAAGIPPAQRRPVQEAAAALRAPGDPVARAAPALSTEVEELLAGHPLRELVTRGENHQVWVDRPLARRGAWYEMFPRSTGGWDTDGNPVHGTFATAAAALPRIAAMGFDVVYLPPIHPIGHVHRKGRNNSTTAEPGDVGSPWAIGSAEGGHDAVHPALGTIDDFDDFVAAAHRLDLEVALDLALQCAPDHPWASQHREWFTELPDGTIAYAENPPKKYQDIYPLNFDNDPAGLYAEVLRVVRFWMVHGVKVFRVDNPHTKPPDFWIWLIAAVKNIDPDVLFLSEAFTPPARQYGLAKLGFTQSYTYFTWRTSKSELTEFGQQIAELADYRRPNLFVNTPDILHASLQSGGPGMFAIRAVLAATLGPTWGVYSGFELFEDRALREGSEEYLDSEKYQLRPRDFAAAVAEGRSLEPFIARLNEIRRMHPALSQLRTVHFHSVDNDALLAYSKFDPDSGDTVLVVVNLNPFVPEHATLRLDMWALGMEDYQRFWVRDQISGEDYHWGRENWVRLDPARAVAHIVNMPPINAQARTALLRRR
>NC_015576.1|WP_013828266.1|1418927_1421150_-|1,4-alpha-glucan-branching-protein-GlgB
MARQLAPAAADLTRLLAGEHHDPHAILGAHEYGEVTVVRVLRPRARRAVVVVGTDRFPMRHLGSGLFAVALPLTGLADYRLELHYPDAAAFAEPTGIHTVADGYRFAPTLGEVDLHLFAEGRHERLWDVLGAHRRTFTTAGGDVSGVSFAVWAPNATGVGLIGDFNGWDSNDAPLRALGSSGVWEVFWPDFPPDGLYKFRIHGADGSVSDRADPFAFATEVPPRTASRVTHSDYRWGDADWMTQRAGRDPVAEPMSIYEVHLGSWRPGLSYRQLAVELTEYVVQHGFTHVELLPVAEHPFGGSWGYQVTSYYAPTARFGTPDDFRALVDALHRAGIGVIVDWVPAHFPKDAWALGRFDGTPLYEHADPRRGEQLDWGTYVFDFGRPEVRNFLVANALYWLTEFHVDGLRVDAVASMLYLDYSRPEGGWTPNIHGGRENLEAVQFLQELNATAHRVAPGIVTIAEESTSWPGVTRDTSLGGLGFSMKWNMGWMHDTLSYLGHDPVHRSYHHHEMTFSMLYAYSENFVLPISHDEVVHGKGTLWTRMPGDDHAKAAGVRTLLAYQWAHPGKQLLFMGQEFGQRGEWCNERGVDWFQLDPHTEPDGYSPGILRLVGDINAHYRALPALWSQDGDPRGYSWIDANDSTNNVLSFLRYGADGSMLACVFNFSGVEHADYHLGLPRAGRWREVLNTDAVGYRGSGAGNLGGVAATDDPWHGRPASAVLLLPALSALWLAPSSPEQT
>NC_015576.1|WP_013828265.1|1417976_1418870_+|tetratricopeptide-repeat-protein
MTRPRPPIGPALAGAVDLSGLKQPPGGAGGDGSAPPGATEITEANFEDEVLVRSNQVPVVVLLWSPRSEACIKLADTLGALATSDGGTWSLATVNVDVAPRVAQVFGVEAVPTVVALAAGQPITSFQGVQPPDQLRRWVDSLLSATAGKLSGGVETEQPEQVDPALARARDQLDAGDFAAARDSYQELLAADPDHVEAKAALRQLTFLERATGRQPDAPALADAAPDDIEAAFAAADVQILNQDVTAAFDRLIALVRRTSGDERSTVRARLVELFELFDPADPEVVAGRRNLANALY
>NC_015576.1|WP_013828264.1|1416648_1417830_+|acetyl-CoA-C-acetyltransferase
MTTSVIVAGARTPIGKLMGSLKDFSGSDLGAIAIAGALEKAGVPASLVEYVIMGQVLTAGAGQMPARQASVGAGIGWDVPALSINKMCLSGIDSIALADQLIRAGEFDVVVAGGQESMTKAPHLLMDSRSGYKYGDVTVLDHLAYDGLHDVFTDQPMGALTEQRNDADKFTRAEQDECAAESHRRAAAAWKDGVFADEVVPVKIPQRKGDPLEFTEDEGIRANTTAESLAGLKPAFRKDGTITAGSSSQISDGAAAVVVMSKAKAQQLGLDWLCEIGAHGVVAGPDSTLQSQPANAIKKAIAREGISVDQLGVVEINEAFAAVSLASTRELGVNPDVVNVHGGAIAVGHPIGMSGARITLHAALELKRRGSGYAVAALCGAGGQGDALILRTG
>NC_015576.1|WP_013828263.1|1416071_1416566_-|methylmalonyl-CoA-epimerase
MTTDSVTDPFEVRSALASALVTAIDHVGIAVPDLEAAKKWYHDQLGMIVLHEEVNDEQGIVEAMLAVRGAPVGSAQLQLMAPIDESSTIAKFLDKRGPGLQQLAYRTSDIDALSQRLRDQGVRLLYDAPRRGTSNSRINFIHPKDAGGVLVELVEPAGDTAAVH
>NC_015576.1|WP_013828262.1|1414672_1415767_+|NADH:flavin-oxidoreductase
MAVEDLFQPLTVRSLTVPNRFAMAPMTRRASPSGVPGTDVAEYYRRRAAGGVGLIITEGIRLPDPAAGYPFSVPTIAGDEVLAGWRRVVDGVHAEGATIAAQLWHQGVERDDSDGVEPVGPSGINGRGEPRGRALRTDELPEVAQLFANSAATARDIGFDAVEIHGAHGYLLDEFLWERTNRRTDGYGGSLAGRTRFPAEVVAAVRAAVGPDYPIIFRFSQWKGTDYTAWIADDPAQLADLLAPLIDAGVDVLHPSTRRHYLPAFPDDDPELSLAGWSKKVSGAPVITVGSVGLETQFRSEKRGEVIQPAPVDRLVEQFDAGEFDVVAIGRALLADPTWVNRLRRGELDRFAGYDAAVALAALA
>NC_015576.1|WP_013828261.1|1413946_1414618_+|endonuclease-NucS
MRLVIAQCTVDYVGRLTAHLPSARRLLLLKADGSVSVHADDRAYKPLNWMSPPCRLTEERAGEFAVWVVTNKTGDQLRITIEEIEHDSSHELGVDPGLVKDGVEAQLQALLAEHVELLGEGYSLVRREYMTAIGPVDLLCRDEQGRSVAVEIKRRGEIDGVEQLTRYLELLNRDSLLAPVSGVFAAQQIKPQARTLATDRGIRCVTLDYDAMRGMNSDEYRLF
>NC_015576.1|WP_041317480.1|1412295_1413900_-|HAMP-domain-containing-protein
MKAPKTTAQRMGRVLELLTRQTDRLPETPEYGSWLLGRVSESQYLRRIRIQFILTVVIVGTNLIGIGVEALLLAVAFPSPSVFFDAPGWLTYGVVPAYIVLALIFGTYWITRRTIKKLRWAIREQQPTRVDERNAFLAPWRVAQVVLALWGVAAMLFTVLYGMADNYFIPIVAFTVGVCGIQVATACYLCTEFALRPVAAQALAAGPPPRRFFSGIMGRTMMVWLLSSGVPVLGIALTAIFALVLKNLSMTQFGVAVLVVAVATAVFGFLLMWILSWLTAAPVRVVRAALRRVEQGNLGADLVVFDGTELGELQSGFNAMVHGLRERERVRDLFGRHVGREVAAAAERDRIQLGGEERHVAVLFVDIIGSTQIVTAKPATEVVTLLNRFFAVVVDEVDRHRGLINKFEGDASLAIFGAPNHLDQPEDEALAAGRAILSRLADEVPEIRAGIGVAAGQVVAGNVGAKERFEYTVIGEPVNEAARLSELAKIRELQLLTTARTLRAASISEQAHWVLGDSVVLRGYDQPTVLAGPL
>NC_015576.1|WP_041317485.1|1429818_1430085_+|YdeI/OmpD-associated-family-protein
MTSQRLPGGAVHELPADLRDGLLVSSTALAAWESITPLARNEFICWVEDAKQQATRERRIRRTREELEEGKRRPCCWPGCKHRERTGS
>NC_015576.1|WP_013828272.1|1430131_1430374_+|hypothetical-protein
MSKVMHIRDVPDEVHAALVEAAAAQGLSLTRYLQRELEHLAKRAQVVRHNAAVIRRTQRAVEGRADRDTILSVLHEGRGE
>NC_015576.1|WP_041317488.1|1430370_1430748_+|type-II-toxin-antitoxin-system-VapC-family-toxin
MKIVDAGVVVELLVGGLDPQRLGHEELAAPHLVDSEVTQVLRGLVRRGVLGAKQGDLAMDGFMRLTLTRFPADWLRPRIWELRDNLSAYDATYVALAELVDATALLTTDARLANAPGPRCRVDLL
>NC_015576.1|WP_049793006.1|1430749_1432018_-|nicotinate-phosphoribosyltransferase
MLAAALRDGTAGRRTGFELFARRLPEGRRYGVVAGTDRFLGALTSFGFDDADLGLLSEFLDPDTVSYLRDFRFRGDVDGYAEGELYFAGSPVLSVRASFAECIVLETLLLSIFNHDTAVASAAARMVSAADGRPLIEMGSRRTHEQAAVAAARAAYLAGFAGTSNLEAHRSFGVPVLGTSAHAFTLLHAGSDVADGDGELAAFRAQVAALGVGTTLLVDTYDVTTGVANAVEAAGSRLGAVRIDSGELAVLAHQVREQLDRLGATATRIVVSGDLDEFAIAALRAAPVDSYGVGTAVVTGSGAPAAGFVYKLVEVDGVAVHKRSADKTSAGGCKQALRTFRPSGTLVEEVVHPAGRPPEVSGPHRLVTVPLVRGGDVVTDTGPAALAAARDRVASGLLSLPWEGLKLARGEPAVSIRLISSR
>NC_015576.1|WP_041317491.1|1432127_1432442_+|ATP-dependent-Clp-protease-adapter-ClpS
MATSAATSAPVKPQGTGQRHADPVEDTASPWVTIVWDDPVNLMTYVTYVFQKLFGYSEPHATKLMLQVHHEGKAVVSAGSRESMEVDVSKLHAAGLWATMQQDR
>NC_015576.1|WP_013828276.1|1432473_1433070_+|DUF2017-domain-containing-protein
MHKWKRVETDGGPRFRSALALHEAALLRNLVGSIIGMLEARESASPPDELEQITGMKTGNTQPPEDATTRRLLPDFYRADGGGAAADGSALDAEGLNAALRSLHEPEIIDAKRGAAQQVLDTLPERGGRFELTEEQANAWIAAVNDIRLALGTMLQIGPNGPDRLPPGDPRAGQLNVYQWLTVLQEYLVVALMGRPGR
>NC_015576.1|WP_013828277.1|1433066_1434155_+|P1-family-peptidase
MTDTGSITDVAGIRVGHHHRLDPDATLGSGWASGVTVVLAPPGTVGAVDSRGGAPGSRETDLLDPANSVRWVDAVVLAGGSAYGLASADGVMTWLEEQGRGVALDGGVVPIVPAAVIFDLPVGGWDRRPTAEFGYAAAAAAAGPDGARPATGCVGAGVGARAGVFKGGVGTASITLELGEHGEHSVTVGALVVVNPSGEVIDATTGLPWSAYLVEEFGLTAPPSEELAVLAGLEPKSRSLNTTIAVVATDAALSPAGCRRMAIAAQDGLSRTIRPSHTPVDGDTVFALATGAVEVPELADTPAAMSPETGLVAEVGAAAADCLARAVLAGVLAADPVAGIPTYGGTLPGAFGSKPAGSTGRS
>NC_015576.1|WP_041317494.1|1434162_1434816_+|rhomboid-family-intramembrane-serine-protease
MSSRSGASPAPRSDTKPLWRTGGASVVGFVALLYLVEAVDQLGGHGLDRNGIRPLQSDGLWGVLFAPLLHANWAHLLANTGPALVLGFLMTLAGQTRFLLATAIVWLVGGLGTWLIGNVGSACGPTDHIGASGLIFGWLAFLVVFGWFTRRIWQILVGLVVLVLYGGILWGAVPVLNVCGGVSWQGHLCGAIAGVLAAYLLSGPERNARARRRGVSA
>NC_015576.1|WP_013828279.1|1434812_1435619_+|glutamate-racemase
MIGIFDSGVGGLTVARSIIDQLPDEDIVYVGDTANGPYGPLTIPEVRAHALAIGDDLVERGVKALVIACNTASAACLRDARERYDVPVVEVILPAVRRAVATTRNGRIGVIGTQATITSHAYQDAFAAARDTEITGVACPRFVDFVERGITSGRQVLGLAEGYLEPLQRAGVDTLVLGCTHYPLLSGLIQLAMGEQVTLVSSAEETAKELLRVLTERDLLRPHGTPPATRLFEATGDPEAFAALATRFLGPAITGVGAVRRHAPLSRS
>NC_015576.1|WP_013828280.1|1435698_1436475_+|MBL-fold-metallo-hydrolase
MRLTVLGCSGSVVGPDSPASGYLLQAPGTPPLVIDFGGGVLGALQRHVDPGSVYVLLSHLHADHCLDLPGLFVWRRYHPSVAATPFPKGVIYGPSDTWSRMGAASSPYGGEIDDITDIFDVHTWVDGEAVEFGSLSVQPNLVSHPTESFGMRITDATGAILVYSGDTGYCDQVIELARGADVFLCEASWTHEANRPPNLHLSGTEAGRIAAAAGVGQLLLTHIPPWTSREDVIGEAKAEFDGPVHAVVCDESFDIRRS

Crispr_ID: NC_015576_7

• CRISPR_ID: NC_015576_7
• CRISPR_location: 3120343-3120428
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_015576_7

Consensus_repeat	Method
CTCTCCTTCGTCGAGCCTCGCTGAACCGC	CRISPRCasFinder

spacers of NC_015576_7

>7.1|3120372|28|NC_015576|CRISPRCasFinder
GGTGTTGATGCGGCGGTCCCAGCTTCAC

CRISPR arrays and Neighbor proteins around NC_015576_7

CRISPR arrays

The CRISPR arrays of NC_015576_7

>merge|NC_015576|7|3120343-3120428|CRISPRCasFinder
CTCTCCTTCGTCGAGCCTCGCTGAACCGCGGTGTTGATGCGGCGGTCCCAGCTTCACCTCTCCTCCGTCGAGCCTCGCTGAACCGC

>NC_015576|7|7|3120343-3120428|CRISPRCasFinder
CTCTCCTTCGTCGAGCCTCGCTGAACCGC	GGTGTTGATGCGGCGGTCCCAGCTTCAC
CTCTCCTCCGTCGAGCCTCGCTGAACCGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015576.1|WP_158019490.1|3114593_3116726_-|UvrD-helicase-domain-containing-protein	unknown	unknown	gnl|CDD|223288
NC_015576.1|WP_013829848.1|3126552_3126849_+|MGMT-family-protein	unknown	unknown	gnl|CDD|226219
NC_015576.1|WP_013829853.1|3131055_3131313_-|DUF3107-domain-containing-protein	unknown	unknown	gnl|CDD|378634
NC_015576.1|WP_013829843.1|3117136_3118051_-|NAD(+)-diphosphatase	unknown	unknown	gnl|CDD|234699
NC_015576.1|WP_013829835.1|3108077_3109097_-|PDZ-domain-containing-protein	unknown	unknown	gnl|CDD|226011
NC_015576.1|WP_013829846.1|3122561_3125696_-|ATP-dependent-helicase	unknown	unknown	gnl|CDD|223288
NC_015576.1|WP_013829851.1|3129115_3130150_-|DUF3152-domain-containing-protein	unknown	unknown	gnl|CDD|371483
NC_015576.1|WP_041318419.1|3109198_3110542_+|zinc-dependent-metalloprotease	unknown	unknown	gnl|CDD|378392
NC_015576.1|WP_013829838.1|3111709_3112579_+|cyclodehydratase	unknown	unknown	gnl|CDD|274832
NC_015576.1|WP_041318427.1|3116801_3117062_+|mycoredoxin	unknown	unknown	gnl|CDD|131255
NC_015576.1|WP_041318425.1|3114014_3114281_-|WhiB-family-transcriptional-regulator	unknown	unknown	gnl|CDD|376791
NC_015576.1|WP_013829837.1|3110551_3111412_-|acyltransferase-family-protein	unknown	unknown	gnl|CDD|153249
NC_015576.1|WP_013829849.1|3126863_3127718_-|TIGR02569-family-protein	unknown	unknown	gnl|CDD|131620
NC_015576.1|WP_013829850.1|3127826_3129005_-|adenylyltransferase/sulfurtransferase-MoeZ	unknown	unknown	gnl|CDD|181156
NC_015576.1|WP_081465553.1|3125702_3126542_+|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|184875
NC_015576.1|WP_013829844.1|3118047_3119124_-|NAD-binding-protein	unknown	unknown	gnl|CDD|367001
NC_015576.1|WP_013829852.1|3130353_3131040_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228
NC_015576.1|WP_013829855.1|3132353_3133880_+|DEAD/DEAH-box-helicase	unknown	unknown	gnl|CDD|223587
NC_015576.1|WP_041318422.1|3112636_3113998_+|AarF/ABC1/UbiB-kinase-family-protein	unknown	unknown	gnl|CDD|223733
NC_015576.1|WP_041320051.1|3131413_3132109_-|hydroxylase	unknown	unknown	gnl|CDD|205967

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015576.1|WP_158019490.1|3114593_3116726_-|UvrD-helicase-domain-containing-protein	gnl|CDD|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	1.50685e-112
NC_015576.1|WP_013829848.1|3126552_3126849_+|MGMT-family-protein	gnl|CDD|226219	COG3695, COG3695, Predicted methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair].	1.06097e-24
NC_015576.1|WP_013829853.1|3131055_3131313_-|DUF3107-domain-containing-protein	gnl|CDD|378634	pfam11305, DUF3107, Protein of unknown function (DUF3107). Some members in this family of proteins are annotated as ATP-binding proteins however this cannot be confirmed. Currently no function is known.	6.61495e-35
NC_015576.1|WP_013829843.1|3117136_3118051_-|NAD(+)-diphosphatase	gnl|CDD|234699	PRK00241, nudC, NAD(+) diphosphatase.	2.46495e-113
NC_015576.1|WP_013829835.1|3108077_3109097_-|PDZ-domain-containing-protein	gnl|CDD|226011	COG3480, SdrC, Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms].	5.79488e-119
NC_015576.1|WP_013829846.1|3122561_3125696_-|ATP-dependent-helicase	gnl|CDD|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	1.8212e-64
NC_015576.1|WP_013829851.1|3129115_3130150_-|DUF3152-domain-containing-protein	gnl|CDD|371483	pfam11350, DUF3152, Protein of unknown function (DUF3152). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.	5.37027e-123
NC_015576.1|WP_041318419.1|3109198_3110542_+|zinc-dependent-metalloprotease	gnl|CDD|378392	pfam10103, Zincin_2, Zincin-like metallopeptidase. This family of proteins has a conserved HEXXH motif, suggesting they are putative peptidases of zincin fold. The structure of this family has similarity to Peptidase_M1 (pfam01433, Structure 3CMN).	2.28318e-149
NC_015576.1|WP_013829838.1|3111709_3112579_+|cyclodehydratase	gnl|CDD|274832	TIGR03882, hypothetical_protein, bacteriocin biosynthesis cyclodehydratase domain. This model describes a ThiF-like domain of a fusion protein found in clusters associated with the production of TOMMs (thiazole/oxazole-modified microcins), small bacteriocins with characteristic heterocycle modifications. This domain is presumed to act as a cyclodehydratase, as do members of the SagC family modeled by TIGR03603.	4.1489e-05
NC_015576.1|WP_041318427.1|3116801_3117062_+|mycoredoxin	gnl|CDD|131255	TIGR02200, conserved_hypothetical_protein, Glutaredoxin-like protein. This family of glutaredoxin-like proteins is limited to the Actinobacteria and contains the conserved CxxC motif.	1.17974e-32
NC_015576.1|WP_041318425.1|3114014_3114281_-|WhiB-family-transcriptional-regulator	gnl|CDD|376791	pfam02467, Whib, Transcription factor WhiB. WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.	5.12471e-13
NC_015576.1|WP_013829837.1|3110551_3111412_-|acyltransferase-family-protein	gnl|CDD|153249	cd07987, LPLAT_MGAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.	1.68594e-35
NC_015576.1|WP_013829849.1|3126863_3127718_-|TIGR02569-family-protein	gnl|CDD|131620	TIGR02569, conserved_hypothetical_protein, TIGR02569 family protein. This protein family is found, so far, only in Actinobacteria, including as least five species of Mycobacterium, three of Corynebacterium, and Nocardia farcinica, always in a single copy per genome. The function is unknown. [Hypothetical proteins, Conserved].	1.05618e-125
NC_015576.1|WP_013829850.1|3127826_3129005_-|adenylyltransferase/sulfurtransferase-MoeZ	gnl|CDD|181156	PRK07878, PRK07878, molybdopterin biosynthesis-like protein MoeZ; Validated.	0
NC_015576.1|WP_081465553.1|3125702_3126542_+|alpha/beta-hydrolase	gnl|CDD|184875	PRK14875, PRK14875, acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional.	3.8632e-16
NC_015576.1|WP_013829844.1|3118047_3119124_-|NAD-binding-protein	gnl|CDD|367001	pfam02254, TrkA_N, TrkA-N domain. This domain is found in a wide variety of proteins. These protein include potassium channels, phosphoesterases, and various other transporters. This domain binds to NAD.	3.264e-23
NC_015576.1|WP_013829852.1|3130353_3131040_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	9.86876e-18
NC_015576.1|WP_013829855.1|3132353_3133880_+|DEAD/DEAH-box-helicase	gnl|CDD|223587	COG0513, SrmB, Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis].	6.17826e-150
NC_015576.1|WP_041318422.1|3112636_3113998_+|AarF/ABC1/UbiB-kinase-family-protein	gnl|CDD|223733	COG0661, AarF, Predicted unusual protein kinase [General function prediction only].	1.03219e-112
NC_015576.1|WP_041320051.1|3131413_3132109_-|hydroxylase	gnl|CDD|205967	pfam13794, MiaE_2, tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like.	4.86412e-54

Protein sequences

>NC_015576.1|WP_013829844.1|3118047_3119124_-|NAD-binding-protein
MASARWRRLRGLDEPLTAQPSYALVGRMHMPQRQSSPGRTVYRRTAIAFAALLVSTLLVYLDRDGYQDVQGDRLSFLDCLYYSAVTLSTTGYGDITPVTEFSRMINVLVITPLRIAFLILLVGTTVEAFTENSRQAFRIQRWRRRVKDHTIVIGYGTKGKTAIAAMRGDDESPPKDIVVVDNDQAVLDQAEGKGLVTVRGDGTKSDVLRLASAQRAAAIVVATGRDDTAALVTLTAREIAPEATIVAAIREAENQHLLEQSGANSVVVSSETAGRLLGIATTTPSVVEIIEDLLTPDAGYAIAEREVEQQEVGGSAKHLNDIVLAVVRDGQLLRLDAPELDAVEAGDRLLYVRTVNNP
>NC_015576.1|WP_013829843.1|3117136_3118051_-|NAD(+)-diphosphatase
MSFRLRQIPLLSRVGADRADQLRTDTDAAVAGWPHAALLRVDARNQVLVAGGRVVLHDTTELGQTPPTDAVFLGRIEDGRHVWAIRGALQAPPDGDVSVLDLRVTGDVFDDTSAQLVSSAIALLNWHENARFSAVDGTPTKPVRSGWARANPITGAEEFPRIDPAVICLVHDGADRVVLARQHNWPVRMFSLLAGFVEAGESFEACVVREVHEEVGLAVRDVSYLGSQPWPFPRSLMVGFHAVADPGQEFVFSDGEITEAAWFTRDEVRAALSAGAWTGGAADAKLLLPGSISIARTIIESWVD
>NC_015576.1|WP_041318427.1|3116801_3117062_+|mycoredoxin
MTVSDPPLIMYTTQWCGYCRQLKKALEKFEIGYDEINIEQDPTAAKFVESVNGGNRTVPTLRFADGSTMTNPTGREVKAKLDRLSS
>NC_015576.1|WP_158019490.1|3114593_3116726_-|UvrD-helicase-domain-containing-protein
MADPNGVPADGLIAGLDDEQRAAVLAPRGPVCVLAGAGTGKTRTITHRIAHLVAAGHVAPGQVLAVTFTQRAAGEMRSRLRALGSAAGGEGGVGNGVGAVQALTFHAAARRQLRYFWPRVVGETGWELLDRKFGVVARAAGHAGLRLSNDDVRDIAGEIEWAKASLIGPEQYPEAVAAAGRDTPIDAAKLADVYAGYEALKARGEVAMLDFDDLLLHTAAAIENDAAVAAEFRDRYRCFVVDEYQDVTPLQQRVLSAWLGERDDLTVVGDANQTIYSFTGASPRYLLDFTRRFPDAALVRLERDYRSTPEVVSLANRVIAAARGRVAGSKLKLVGQREPGPLPTFREHPDEVAEATAVAKSIARLIDGGVAPAEIAVLYRVNAQSEVYEEALTEAGIAYQVRGGEGFFHRQEIRQALVALRRTAERGDDTGSALPETVRRVLEPLGLTAEPPSGVRARERWEALGALAELVDDEVAQRPDLDLPGLLAELRVRADSRHPPTVQGVTLASLHAAKGLEWDAVFLVGLVDGTLPISHALAHGPDSEAVEEERRLLYVGVTRARVHLALSWALARAPGGRAGRKPSRFLHGIDGAVPQPDPRAPARRRARGAPKHCRVCNKALGTPAAIMLSRCETCAADVDTELLVALKDWRLRTATELKVPAYIVFSDNTLTAIAEMLPADEAALVAIPGIGARKLEQFGSDVLELVRNRS
>NC_015576.1|WP_041318425.1|3114014_3114281_-|WhiB-family-transcriptional-regulator
MSTTTARTRRLPELPCNRDPDLWFADNPADLERAKVLCGDCPIRRQCLALALQRGEPWGVWGGEILDRGTVIGRKRPRGRPRKQPLAA
>NC_015576.1|WP_041318422.1|3112636_3113998_+|AarF/ABC1/UbiB-kinase-family-protein
MDDGHVSEIKRGSAARNAKLASLPVGFAGRAALGFGKRLTGKSKDEVTAELMEKAANQLFTVLGELKGGAMKVGQALSVMEAAIPEEFGEPYREALTKLQKDAPPLPADKVHRVLDAQLGTKWRERFSDFDDTPVASASIGQVHRGVWADGRRVAVKIQYPGADEALRADLKTIRRLTGIFKQLAPGVDVKGVIDELIERTEMELDYRLEADNQRVFAKAYAGHPHFLIPNVVASAPKTVIQEWIDGIGMAEIIRNGTVEQRDLMGTRLAEFTWDAARRLELIHGDAHPGNFMLLPDGRMGVIDFGAVAPMPGGFPPELGAAVRYARDNDYEQVIAVMRQGGFIQKGQNVSVREIDEMLRQYVEPVEVEVFHYTRKWLMRMAGKQLERPVEQLKTARQLDLPPKLAMPMRVLGSTTAIMCQLDAHVPVKRISEELVPGFVTDPDSGATVGPSA
>NC_015576.1|WP_013829838.1|3111709_3112579_+|cyclodehydratase
MTRVESQTHAYTLDPARPVLLRPDGAVQVGWDPGRAVLVQPPRGLTATGLAAVLRTMQTPATAAELRLEAARHGTVDTAELDNLLSALVGAGVAVRDSAPRRPRRTASLRVHGRGPLSDLLVESLRCSGAVVRRSSQPHAAVSTAGTDLVVLSDYLVADPRLVRELHAERVAHLAVRVRDGTGVVGPLVLPGMTSCLGCADLHRRDRDASWPAVAAQLRDTVAHSDRATVLATVALALSQVDRVIAAVRGPAAGSDLGPPPTLNATLEMDLATGSIMTRRWARHPLCGC
>NC_015576.1|WP_013829837.1|3110551_3111412_-|acyltransferase-family-protein
MHVLRDIDAIVNQPPRVQALRRVMAAVADAVTPAVEAYRPYVDGLDNLPPDGRFLLVGNHTQVSAEALLIPFHVRRAIGKRVRPLTDRQFGRMRGPARDLLAAAGALVGAPEPVRELMRRNEPILVFPGGGREIPKFKGEEYTLRWQGRAGFARLAVESRYPIVPVGLVGGDDVYRSLSSRGGTWERISTAVSRRLSGPPDMAIPLQHGIGPTLIPRPQRMYLRFGAPIDTTKPARISVDNWVATVREKSQQSLEEILEDLLAVRADDPFRHLNPLAWRDATAPPA
>NC_015576.1|WP_041318419.1|3109198_3110542_+|zinc-dependent-metalloprotease
MADLPFGFSSGDDPDRERPGGRDPGPSDWGMGAGFNIADLGQIFTQLGQMFSGAVSTSGRPSGPVNYDLARQVAARSIGSVAPVTASTTTAIGDAVHLAETWLNGATSLPAGTTGSAAWTPVDWVEHTMATWQRLCDPMAEQVSSVWASALPEEAKSMAGPLLSVMSQMGGLAFGSQLGQALGRLSGEVLTSTDIGLPLGPKGVAALLPGAIEELAGGLEQPRSEIVTFLAAREAAHHRLFTHVPWLANQLLSAVEAYARGMKIDIRGIEELAQGFDPAAMSDPSAMADLLNQGVFEPKSTPEQLAALERLETLLALIEGWVRTVVTAALGERIPGTAALSEMLRRRRATGGPAEQTFATLVGLELRPRKLSEAAVLWERLTVAVGVDARDQVWQHPDLLPEAADLDDPAAFIDRIIGGDTSGIDSAIDQAIAEFQRDADASGDTDD
>NC_015576.1|WP_013829835.1|3108077_3109097_-|PDZ-domain-containing-protein
MNRRILTLLAALLPVVVFGALLTAVTVPFVSLGPGPTFDTLGMVDGKQVVDIQGTPTRTTSGHLNMTTVSQRDGLTLGEALALWLSGREQLMPRDLVYPPGKSREEVDEDNDAEFRTSEQSAEYAALGYLRYPSAVTLAEVHDPGPSAGALQRGDAVDAVDGEPVYTVEQFTKRLSATKPGDTVAIDYRRKNAAPGTARITLGENKDRPNGFLGVSVLDAPWAPFTVEFNLANIGGPSAGLMFSLAVVDKLGTGTLAGQNFIAGTGVIKPNGQVDSIGGITHKMIAAREAGATVFLVPAENCYEARSDPNGLQLIKVDSLAQAVDALRTLTGGGQPPSC
>NC_015576.1|WP_013829846.1|3122561_3125696_-|ATP-dependent-helicase
MTQHWEPYAGEVAAALDPLRRGVLQVRGGPGTGKTSLLLEVAAAHVAAGADADSLLLLTGSGRLPAAARGALTATLLAAGGPAATRAIREPLVRTVHGYAFAVLQRAARRAEAAPPRLVTGAEQDSVIRELLAGDGARAWPSSLHAALGTDGFATELRDLMARCAERGVDPAELVRLGKRYRRPEWTAAGRFARQYEQVMLLRAAVGTAAPQATTPALGAAELVGAALEAFAADPGLLVEERSRLRLLLVDDAQLLDPQAARLVRVLAAGVQRTVIAGDPDQAVFGFRGAEPAALLSDDPTPGGAPTVHLTASHRCAPAVIRAVNTIAARLPGRSATRRLEAVGPDAGSVTVRTAVSGHAEAALIADTLRRAHLVDGVPWSQMAVIVRSVPRAAARLPRTLTAAGVPVALPIAGGLLAQQPAVAALLTVLQCAAEGVDGPRALALLTGPIGRVDPISLRQLQRVLRRGAAADPESDPGDRLVAVLRGEAGQLPVAHARALRRVRAVLQAAARSHADGRDPHHTLWQAWNRSGLQQRWLSATQRGGPAGAQAGRDLDAVTALFDLTEHYVARTAGATLTGLIEHVTAMQLVMPRTEAAAGVEAVEVLSAHAALGREWDLVVIAGVQEGLWPNTVPRGGVLGTQRLLDSLHGLGDEVSARAPLLAEERRLLVAAMGRARHRLMITAVDGEGDGGATEEQLPSEFHAELAACATPDGVPAPAPPVAAPPVLSAAGVVGRLRAAVCAPDGVVTDSERADAATQLARLVRAGVPGADPADWHGTAPVSTEEPLWRTEGGQVVTLSPSALQSLLDCPLRWLAERHGGTDGRDLRSTIGSLMHALVAESAVSREELLAELDRAWRQLPFESPWHSANEQDRHRAMIETFLAWRAQTRDELTEVGTEIAFDGVIDAGEGVRLRGRIDRIERDAAGRLVVVDVKTAKTPVSKDDAQQHAQLAVYQLAVEAGLVGPDEQPGGARLVYPAKTAAGGATEREQDPLTPESGRDWRERIAAAAAATAGPQFTARVNDGCRHCPIRPICPAHTGGSGA
>NC_015576.1|WP_081465553.1|3125702_3126542_+|alpha/beta-hydrolase
MTPLPSDNPGEGWHHRRVNSDHRLHVHRYGPAGPIQLLAVHGLTGHGARWRHVAGQLPETTVAAPDLIGHGHSSWAAPWTIDANVAALIGLLEDGAGGPVVVVGHSFGGAIALHLAAARPDLVHSVVLLDPAIGLDGHWMAEIAAAMLASPDYPDAAEARAEKANGGWSDVDPALLDAELAEHLVALPGGRFGWRISVPAMMSYWSELARPLVLPRSTPTTLLRATRTSPPYVDARLIEALQTRLCTKFQLVDLDCNHMVDQARPAEVAAVIHDRLARN
>NC_015576.1|WP_013829848.1|3126552_3126849_+|MGMT-family-protein
MATVTDEQVERVRALILGIPAGRVATYGDIASAAGLSSPRIVGWILRVDGADLPWHRVIRASGRPATQLRTEQLARLRAEGVTAVDGRVDLRAARHRF
>NC_015576.1|WP_013829849.1|3126863_3127718_-|TIGR02569-family-protein
MTVEPPPEHVLATFGLRSMEPTPLGAGWEDGWKCGEVVVSMVADHARAAWSAKVRETLFADGIRLARPVRSTDGRYVVSGWRADTFVAGSPEPRHDEVVSAAVRLHEATAKLERPRFLTQAPVAPWADVDVFIAADRAAWEEKPFASLQAGARLAPGSVDGQRSIDLINQLATLRKPTKGSSQLVHGDLYGTVLFSGAAAPGITDITPYWRPPSWAAGVVVVDALSWGDADDGLIERWDSLPEWPQMLLRALMFRLAVHALHPRSTAEAFPGLARTAALVRLAL
>NC_015576.1|WP_013829850.1|3127826_3129005_-|adenylyltransferase/sulfurtransferase-MoeZ
MSRSLPPLVEPAGELTRDEVERYSRHLIIPDVGVQGQKRLKNARVLVIGAGGLGAPTLLYLAAAGVGTIGIIDFDVVDESNLQRQVIHGVADVGRAKAESARDSINAINPLVDVRLHQFRLDASNAVQLFESYDLILDGTDNFATRYLVNDAAALAHRPYVWGSIFRFEGQVSVFWEDAPDGRGLNYRDLYPEPPPPGMVPSCAEGGVLGVLCASVGSVMGTEAIKLITGIGESLLGRLLIYDALEMSYRTIRVRKDPSTPKITELIDYEAFCGVVSADAAEAAAGSTITPAELRELLDSGQQLELIDVREPAEWEINHIEGARLVPQSMLNTGEGLATLPQDRIPVLYCKTGVRSAAALATLKKAGFANAVHLQGGIVAWAKAMQPDMVMY
>NC_015576.1|WP_013829851.1|3129115_3130150_-|DUF3152-domain-containing-protein
MTYDPGQRGGGRAPVLRDRFREPLRAQRDPLAAGTGRLRSDRDVHRQWRKQTWLGSFVSTYGWRAYALPVLMVLTVVVVYQTVTGTGVRAQDSDEPVQGPPTIGSAGTSIIGAPPRGLTEFDVNLPTGVLPDGGPFTEAGAMTWHVVPGTQPVFGRGTEKVFAYTIEVENGIDTTAFGGDEAFARMVDQTLRNPKGWTHTPQIGFVRVDATSGVEPDFRISLTSPLTVREGCGYEIPLEASCYNPSYGARSEPRVFINEARWVRGAVPFQGDIGSYRQYLINHEVGHALGYQHHEPCERQDGLAPVMMQQTFGTSNDDAAKFDPDWVKPDGKTCRFNPWPAPIA
>NC_015576.1|WP_013829852.1|3130353_3131040_+|TetR/AcrR-family-transcriptional-regulator
MSKPIDTAERGGGKSAGRGSGAAKAPAATSRRGSRLPRDERRGQLLIAASEVFVDRGYHAAGMDEIADRAGVSKPILYQHFASKLELYLAVLARHVENLVSGVRQALRTTTDNRQRLRSAVQAFFDFIEHDGQGYRLIFENDNVAEPQVAVQVRVATESCIDAIFDLVSHDSGLDPHRARMVAVGLVAISVDCARYWLDSDRPISKEDAVEGTVAFAWGGLSHVPLTR
>NC_015576.1|WP_013829853.1|3131055_3131313_-|DUF3107-domain-containing-protein
MEVKIGVTDSSRELVINSAQTPDEVEELVVAALGKGTELLALTDDKGRRFLVQAAKIAYVEIGAADSRRVGFGIGSETIARANSS
>NC_015576.1|WP_041320051.1|3131413_3132109_-|hydroxylase
MNSVPSTDAEAQSSPPRLSADHPGVNELFAVLAYGEVAAFYRLTDEARMAPDLRGRISMAAMAAAEMGHFELLRQALDARGVDVVEAMSKYATALDNYHRLTMPSTWLEALVKTYVGDAMAADFYLQIANGLPDEVADVVRAVLAETKHSQFVVDEVRGAVTASAKQRSRLALWSRRLLGEAITQAQYVLADHDELVDLVVAGAAGLAHLAGFFDRIQHTHDERMRELGLA
>NC_015576.1|WP_013829855.1|3132353_3133880_+|DEAD/DEAH-box-helicase
MTPLIATTRPTSPPTFAELGVRDEIVRALAEDGIERAFAIQELTLPLALAGDDLIGQARTGMGKTYGFGVPLLQRVSTSTDRPLTGIPRALVVVPTRELCIQVSGDLADAAKYLTAGDRPLSVQAIYGGRPYEPQIEALQAGADVVVGTPGRLLDLAQQGHLQLGGLTVLVLDEADEMLDLGFLPDIERILARIPDDRQSMLFSATMPGPIITLARSFMNQPTHIRAEAPHSSAVHDATEQFVYRAHALDKAELVARVLQARGRGATMIFTRTKRTAQKVADDLGERGFKVGAVHGDLNQVAREKALKAFRTGDIDVLVATDVAARGIDIDDVTHVVNYQCPDDEKTYVHRIGRTGRAGKTGVAVTLVDWDELARWSMIDKALNLQCPDPAETYSSSPHLFTELNIPTEATGAIGNAGRSPAKRSEGGDGERRESSADRQRAPRNTTRSRRRTRGGRAAGGDTSAPAARTGEPGEARTAGPSDDNGQSAPRRRRRRRPSKTAAAVNGN

Crispr_ID: NC_015576_8

• CRISPR_ID: NC_015576_8
• CRISPR_location: 3522883-3523095
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NC_015576_8

Consensus_repeat	Method
GCCGCCGTTGCCGCCGGTGCCGCCGACCCCGCCGTCGCCACC	PILER-CR

spacers of NC_015576_8

>8.1|3522925|54|NC_015576|PILER-CR
GGCTCCATTGGCACCGGCAGCTCCGCCATCGGCGGTACCGGCGAGGCCGCCGAC
>8.2|3523021|36|NC_015576|PILER-CR
CGGGGTGACAAGGCCCCCGATTGCCAATGTCGCGTT

CRISPR arrays and Neighbor proteins around NC_015576_8

CRISPR arrays

The CRISPR arrays of NC_015576_8

>merge|NC_015576|8|3522883-3523095|PILER-CR
GCCGGCATTGCCGCCCGTGCCGCCGACCCCGCCGTCGCCACCGGCTCCATTGGCACCGGCAGCTCCGCCATCGGCGGTACCGGCGAGGCCGCCGACGCCGCCGGTGCCGCCGGTGCCGCCGGAAGCGCCGTCGCCCGGGGTGACAAGGCCCCCGATTGCCAATGTCGCGTTGCCGCCGTTGCCGCCGGTGCCGCCGTCCCCGCCGACACCACC

>NC_015576|8|1|3522883-3523095|PILER-CR
GCCGGCATTGCCGCCCGTGCCGCCGACCCCGCCGTCGCCACC	GGCTCCATTGGCACCGGCAGCTCCGCCATCGGCGGTACCGGCGAGGCCGCCGAC
GCCGCCGGTGCCGCCGGTGCCGCCGGAAGCGCCGTCGCCCGG	GGTGACAAGGCCCCCGATTGCCAATGTCGCGTTGCC
GCCGTTGCCGCCGGTGCCGCCGTCCCCGCCGACACCACC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015576.1|WP_013830241.1|3530640_3530829_-|50S-ribosomal-protein-L30	unknown	unknown	gnl|CDD|180163
NC_015576.1|WP_013830228.1|3510937_3512269_-|preprotein-translocase-subunit-SecY	unknown	unknown	gnl|CDD|236412
NC_015576.1|WP_013830247.1|3533144_3533708_-|50S-ribosomal-protein-L5	unknown	unknown	gnl|CDD|178791
NC_015576.1|WP_013830226.1|3509600_3510389_-|type-I-methionyl-aminopeptidase	unknown	unknown	gnl|CDD|235576
NC_015576.1|WP_013830234.1|3518002_3519394_-|PPE-domain-containing-protein	unknown	unknown	gnl|CDD|366325
NC_015576.1|WP_013830232.1|3515758_3516064_-|DUF732-domain-containing-protein	unknown	unknown	gnl|CDD|368380
NC_015576.1|WP_041318640.1|3529506_3529716_+|hypothetical-protein	unknown	unknown	unknown
NC_015576.1|WP_013830239.1|3524457_3529305_+|hypothetical-protein	unknown	unknown	gnl|CDD|235906
NC_015576.1|WP_013830244.1|3531983_3532523_-|50S-ribosomal-protein-L6	unknown	unknown	gnl|CDD|235495
NC_015576.1|WP_013830229.1|3512578_3513511_+|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|225852
NC_015576.1|WP_013830231.1|3514475_3515708_+|EstA-family-serine-hydrolase	unknown	unknown	gnl|CDD|365903
NC_015576.1|WP_013830243.1|3531573_3531981_-|50S-ribosomal-protein-L18	unknown	unknown	gnl|CDD|235524
NC_015576.1|WP_041318643.1|3530197_3530641_-|50S-ribosomal-protein-L15	unknown	unknown	gnl|CDD|235523
NC_015576.1|WP_049793053.1|3519785_3520034_-|DUF732-domain-containing-protein	unknown	unknown	gnl|CDD|368380
NC_015576.1|WP_085975778.1|3530831_3531527_-|30S-ribosomal-protein-S5	unknown	unknown	gnl|CDD|234790
NC_015576.1|WP_013830233.1|3516150_3517944_-|signal-peptide-peptidase-SppA	unknown	unknown	gnl|CDD|273226
NC_015576.1|WP_013830245.1|3532536_3532935_-|30S-ribosomal-protein-S8	unknown	unknown	gnl|CDD|234658
NC_015576.1|WP_013830246.1|3532954_3533140_-|type-Z-30S-ribosomal-protein-S14	unknown	unknown	gnl|CDD|181216
NC_015576.1|WP_013830230.1|3513516_3514425_+|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|225852
NC_015576.1|WP_013830227.1|3510389_3510941_-|adenylate-kinase	unknown	unknown	gnl|CDD|234711

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015576.1|WP_013830241.1|3530640_3530829_-|50S-ribosomal-protein-L30	gnl|CDD|180163	PRK05611, rpmD, 50S ribosomal protein L30; Reviewed.	1.4274e-26
NC_015576.1|WP_013830228.1|3510937_3512269_-|preprotein-translocase-subunit-SecY	gnl|CDD|236412	PRK09204, secY, preprotein translocase subunit SecY; Reviewed.	0
NC_015576.1|WP_013830247.1|3533144_3533708_-|50S-ribosomal-protein-L5	gnl|CDD|178791	PRK00010, rplE, 50S ribosomal protein L5; Validated.	1.40238e-125
NC_015576.1|WP_013830226.1|3509600_3510389_-|type-I-methionyl-aminopeptidase	gnl|CDD|235576	PRK05716, PRK05716, methionine aminopeptidase; Validated.	9.9701e-132
NC_015576.1|WP_013830234.1|3518002_3519394_-|PPE-domain-containing-protein	gnl|CDD|366325	pfam00823, PPE, PPE family. This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	2.32119e-56
NC_015576.1|WP_013830232.1|3515758_3516064_-|DUF732-domain-containing-protein	gnl|CDD|368380	pfam05305, DUF732, Protein of unknown function (DUF732). This family consists of several uncharacterized Mycobacterium tuberculosis and leprae proteins of unknown function.	2.14071e-19
NC_015576.1|WP_013830244.1|3531983_3532523_-|50S-ribosomal-protein-L6	gnl|CDD|235495	PRK05498, rplF, 50S ribosomal protein L6; Validated.	2.06242e-109
NC_015576.1|WP_013830239.1|3524457_3529305_+|hypothetical-protein	gnl|CDD|235906	PRK07003, PRK07003, DNA polymerase III subunit gamma/tau.	6.50248e-11
NC_015576.1|WP_013830229.1|3512578_3513511_+|class-I-SAM-dependent-methyltransferase	gnl|CDD|225852	COG3315, COG3315, O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism].	2.68018e-97
NC_015576.1|WP_013830231.1|3514475_3515708_+|EstA-family-serine-hydrolase	gnl|CDD|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	9.43974e-45
NC_015576.1|WP_013830243.1|3531573_3531981_-|50S-ribosomal-protein-L18	gnl|CDD|235524	PRK05593, rplR, 50S ribosomal protein L18; Reviewed.	9.67183e-58
NC_015576.1|WP_041318643.1|3530197_3530641_-|50S-ribosomal-protein-L15	gnl|CDD|235523	PRK05592, rplO, 50S ribosomal protein L15; Reviewed.	2.3678e-67
NC_015576.1|WP_049793053.1|3519785_3520034_-|DUF732-domain-containing-protein	gnl|CDD|368380	pfam05305, DUF732, Protein of unknown function (DUF732). This family consists of several uncharacterized Mycobacterium tuberculosis and leprae proteins of unknown function.	3.34796e-09
NC_015576.1|WP_085975778.1|3530831_3531527_-|30S-ribosomal-protein-S5	gnl|CDD|234790	PRK00550, rpsE, 30S ribosomal protein S5; Validated.	1.13557e-95
NC_015576.1|WP_013830233.1|3516150_3517944_-|signal-peptide-peptidase-SppA	gnl|CDD|273226	TIGR00705, Protease_4, signal peptide peptidase SppA, 67K type. This model represents the signal peptide peptidase A (SppA, protease IV) as found in E. coli, Treponema pallidum, Mycobacterium leprae, and several other species, in which it has a molecular mass around 67 kDa and a duplication such that the N-terminal half shares extensive homology with the C-terminal half. This enzyme was shown in E. coli to form homotetramers. E. coli SohB, which is most closely homologous to the C-terminal duplication of SppA, is predicted to perform a similar function of small peptide degradation, but in the periplasm. Many prokaryotes have a single SppA/SohB homolog that may perform the function of either or both. [Protein fate, Degradation of proteins, peptides, and glycopeptides].	1.25602e-94
NC_015576.1|WP_013830245.1|3532536_3532935_-|30S-ribosomal-protein-S8	gnl|CDD|234658	PRK00136, rpsH, 30S ribosomal protein S8; Validated.	5.25283e-82
NC_015576.1|WP_013830246.1|3532954_3533140_-|type-Z-30S-ribosomal-protein-S14	gnl|CDD|181216	PRK08061, rpsN, type Z 30S ribosomal protein S14.	5.25237e-35
NC_015576.1|WP_013830230.1|3513516_3514425_+|class-I-SAM-dependent-methyltransferase	gnl|CDD|225852	COG3315, COG3315, O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism].	7.70522e-94
NC_015576.1|WP_013830227.1|3510389_3510941_-|adenylate-kinase	gnl|CDD|234711	PRK00279, adk, adenylate kinase; Reviewed.	6.90073e-100

Protein sequences

>NC_015576.1|WP_049793053.1|3519785_3520034_-|DUF732-domain-containing-protein
MKRLLLLAGLSAMIGLAAPALAAPTGVDGQFLATLTGAGLSHTGNDQAAVSAGRAVCQLMDAGLSPMDTVVAVQATNQALPS
>NC_015576.1|WP_013830234.1|3518002_3519394_-|PPE-domain-containing-protein
MDFGLVPPEIQSALMYAGPGPGPISATAAAWDGLAAELDAASASYASLVTDLTSTGWLGSTAALMAAAVSPYLAWMHTTAVQCAETAAQVRAGVAAYEEAFAATVPPPVIATNRAELLTLLATNIFGQNTAAIAANQAEYAEMWAQDAAAMFGYASAASTATQLTPFTAPPKTANSDGSDNTTAAAAQAAGSATATQTQNALAGVPQTLQQLALPMAAPAAADPVVGQATAAGVSGISASSAYHTIIGSANFFQRIYSQFQSSFAASNEPSTTDIMERLNRIGLVTGAVDSDEVGRAADGGPLGTLGLGGFGDWHNWARFFKGFPLLKLSAAGSMGESGLVGGLSVPPTWAEALPDVRLAAAETTGTGVNAAPSAAGGGFGMLGAQAALTGMAGRALAGAVLPARENTRSTAPAQERPSSTAAKEIAEALREYASLRDSGIITEVEFNKHKERLMSLDPLSGR
>NC_015576.1|WP_013830233.1|3516150_3517944_-|signal-peptide-peptidase-SppA
MFSLLPGVPGLDDLRGVARRIDTARHRGVPNGVVLELDLQTMPHETGGFDPLALIRFGAQPPVLRDLVDAIHRAADDPRVAGLIARVQLSAAAAGPVQELRAAIAEFTAVKPSLAWAETYPGTLSYYLASAFGEVWLQPSGMVGLIGFATNATFLRTALGKAGIEAQFVARGEYKSAANLFTQDSYTDAHREADTALVESLHTQVRAAVAESRNLDAGAVDALADRAPLLRDDAVGGGLIDRIGFRDEAYDRIAELVAGGGSPVDADDREAPPRLYLTRYVNATAGNPLVPAPSLPALPGRKNKPAIAVVTVAGAIVSGSGGPQLPPFGNRSVGGDTISAALREAAADDDVAAIVLRVDSSGGSVTGSETIWRAVQQAREAGKPVVASMGAVAASGGYYIATGADTIVANPGTITGSIGVVTGKLVARELKDRLGVGTDTVRTGANADAWSINAPFTAEQQGQVENVADLFYNDFVRRVAQGRNLSTEAVDAVARGRVWTGADAAERGLVDELGGLRTAVRRAKVLAGLDEDAQVRTVSYPGSSLWDFVRPRQSSQPAASLPDAVGGLLMRSLAGILDQAERSVNGAHVLWLGESRW
>NC_015576.1|WP_013830232.1|3515758_3516064_-|DUF732-domain-containing-protein
MKRLLLLAGLSAMVGLAAPAHAAPSGVDGQFLATLSGAGLSHRASDQATVSAGRAVCQLMDAGLSPMDTVVAVQATNPGFTIQTAGQFAAISTAHYCPEHM
>NC_015576.1|WP_013830231.1|3514475_3515708_+|EstA-family-serine-hydrolase
MVLKVDVPQDLIGGDVDEGYGKVADAFRANFAGGHEVGAAVTVYRDGVKVVDLWGGYRDGFTRQPWHRDTMVNVFSSTKGVAALAVALAVSRGMFGYDDKVADHWAEFAQAGKGDVTIRDLLGHRAGLCALKPAPTLADIADPDRLAPILAAQKPLWAPGTRHGYHAITLGWYESELIRRTDPAGRTLGRFFADEIANPLGLDLHIGLPASVPRDRVALLHQWKRAESLRHLGVMPAALVAASFNPFGLLARASSLPRDIKPWDGDYNRDDVRAVEIPSANGIGAASAIARLYGAAATADPLLALGAGVRDALTALPAPPSRGERDKVLGVEVVFSLGLSKPAFGAVFGSTDKAYGTPGFGGSFGFADPDTGVGYSYVMNRLGFHLYSDPRELALRQALFGDVLGARPQT
>NC_015576.1|WP_013830230.1|3513516_3514425_+|class-I-SAM-dependent-methyltransferase
MARTENDSWDLASSVGTTATMVAVARALATAEADPLISDPFAAPLVRAVGIDFFTGMLDGTLEPAVAAEARAAAEPMTAVMAVRTRFFDDFFLQATEAGTRQAVILAAGLDSRAYRLAWPPGSAVYEIDQPDVIEFKTSTLAELGAQPTADRRTVAVDLRDDWPAALRRNGFDETKPTAWSAEGLLIYLPPQAQDRLFDNITALSAPGSRLATEYHPDGAAALGDSNQSLGQRFADQGLDLDMANLVYAGERHPVGPYLNERGWQVNERTRDEVFGCYGRSFPDGDIVARLRSSVAIEALRS
>NC_015576.1|WP_013830229.1|3512578_3513511_+|class-I-SAM-dependent-methyltransferase
MAQTGRFPGDTWDLASSVGVTATGVAAARAMAGRAEHPLIDDPFAEPLVRAVGLDLFTGLASGEIDPADLGDDSPMGMMRMADNMAVRTRFFDDFFLQATEAGIRQAVILASGLDSRAYRLPWPAGTVVYEVDQPEVIEFKTRVLSEHGAAPTAQRRTVSIDLRENWPAALRAAGFEPGRPTAWSAEGLLGYLPPEAQDRLLDTITALSAPGSRVATESMPGLDGDTEEQARRQMREAADRMRSHGLNLDMTELLYFGDRNEAGSYLADHGWQVSSRGVGELFAAHGLPPLQEGDGPGFGGLSYISAIRG
>NC_015576.1|WP_013830228.1|3510937_3512269_-|preprotein-translocase-subunit-SecY
MFSAFISSLRTVDLRRKILFALGIIIIYRLGAAIPSPGVDYQNVQQCIKEVSGGDAAQVYSLINLFSGGALLQLTVFAIGVMPYITASIIVQLLTVVIPRFEELRKEGQSGQNKMTQYTRYLTVALAVLQATSIVALAANGGLLQTCSLRHDIIADHSIFTLVVIVMVMTAGAVLVMWLGELITERGIGNGMSLLIFVGIAARIPIEGKTILDSRGGLVFTMVCLAALVIVVGVVFVEQGQRRIPVQYAKRMVGRRMYGGTSTYLPLKVNQAGVIPVIFASSLIYIPQLVTQLVRSGSGGVGNSWWDKAVSTYLSDPSNLVYIAVYFGLIIFFTYFYVSITFNPDERADEMKKFGGFIPGIRPGRPTADYLRFVLNRITLPGSIYLGVISVLPNLFLQMGNSGTVQNLPFGGTAVLIMIGVGLDTVKQIESQLMQRNYEGFLK
>NC_015576.1|WP_013830227.1|3510389_3510941_-|adenylate-kinase
MRVILLGPPGAGKGTQAVKLAQELGVPQISTGDLFRNNIAQGTELGRKAKAYLDAGDLVPSELTNALVADRIDGEDAAKGFILDGFPRSVEQAQALHDMLEERNTKLDAVLELRVSEDELLARLRERGRADDTAEVIHNRMIVYREETAPLLDFYQHEHELHVVDALGTVDEVFGRLLKALGR
>NC_015576.1|WP_013830226.1|3509600_3510389_-|type-I-methionyl-aminopeptidase
MIGLPKRRVPHRSPGELDAMAAAGAVVAAALAAVREAAVAGTSTLQLDDIAESVIRDAGATPSFLGYHGFPASICSSVNDRVVHGIPSSTEVLELGDLVSIDCGAILDGWHGDAAITLGVGKLAQADEDLSAATRQALGAGIAAMVPGNRLSDVSHAIETGARAASAEFRRSFGIVAGYGGHGIGRQMHMDPFLPNEGSPGRGPLLVAGSVLAIEPMLTLGTDQTVVLDDEWTVVTADSSRAAHWEHTVAVTDDGPRILTVA
>NC_015576.1|WP_013830239.1|3524457_3529305_+|hypothetical-protein
MAGRTPSTPGTTGTTNRTITTRSTRHRTHISRSVIPITTITTTTTGTTGTTIAPSTTYTTNTLGAIGGTMTGRTTIAPSTTITAGTTSLTRAPSTTSSRHRRRRPIDAVLTVGADSTGNPIKPATTHTTIATITASTLNTIKTTSGTRGRQTTRAPSTPITTSTTILTNTTSHPSLRRILTISTRGTIPTPTTSTTRTSDTINTTGRLHATSPDTTGTTGGGITPIATRATGATGLTGVHPINTPSTRRPVTTGTTIATNTTGTQVAGDTISTRTRLTIEATTPGTTVAGRTPSTPGTTGTTNRTITTRSTRHRTHISRSVIPITTITTTTTGTTGTTIAPSTTYTTNTLGAIGGTMTGRTTIAPSTTITAGTTSLTRAPSTTSSRHRRRRPIDAVLTVGADSTGNPIKPATTHTTIATITASTLNTIKTTSGTRGRQTTRAPSTPITTSTTILTNTTSHPSLRRILTISTRGTIPTPTTSTTRTSDTINTTGRLHATSPDTTGTTGGGITPIATRATGATGLTGVHPINTPSTRRPVTTGTTIATNTTGTQVAGDTISTRTRLTIEATTPGTTVAGRTPSTPGTTGTTNRTITTRSTRHRTHISRSVIPITTITTTTTGTTGTTIAPSTTYTTNTLGAIGGTMTGRTTIAPSTTITAGTTSLTRAPSTTSSRHRRRRPIDAVLTVGADSTGNPIKPATTHTTIATITASTLNTIKTTSGTRGRQTTRAPSTPITTSTTILTNTTSHPSLRRILTISTRGTIPTPTTSTTRTSDTINTVTGASGAALPGIAAVPAGSAGLAISTRGHTGLTGCTGGAIATGTAYAAGAQQAAVPAKAAVAAGGARRRVRITGGVVAVAPVTAVALLTGRAVAGRAVRTGCRAGSTATGCAGVTDRTAIAAVAGIGMRGDPVGATAAVGGHPGVAAVAAAATGALAAGGCAVDARAAGTAVAALTAGGAASARATVPAVAGARVVERADRTLHTVTAVAAVAAVGSGTALAAVMTGARAGTAVAAGATRLAGDAVAAGLARLGTRAAVGAAEPCGAVAAIAAVAAADGVTAIAATAAVGASVAAVGAVALHGAAIPAVTAVTAGAGALPGAAVSAGPTVTDLGATVTAGAAVSAVGIVTTASAVAAGPAVADGSAAATGSAGAAGHSGCCRGEAVAAVTAVGFGGCRTGSVGPAAARDSGARGSAGAGCAAGTARSGGAGIAGVTAGAAIHMVRVAVGAITAGTTGCGVASGAAVAAVAIAAGRPGRRGRRASVTPGTTGAAGPPVSSGLSVGARVAGVGAVGSGQSGDPITAPPAIAGITAVSSGRTGTARATAATGTAAAAGRARRRTGGERVISGSAIAADTSGATGAVGCAGGAVGFQSALTAVAAGAAVAPGGSVRVGGGAVDAVDAVAAVAPVAAGPGVAVGAVGGNHPVAAHTTGATAPGIPAVAAADSGGAIRVDSRPVGPGRAVGAITAVLAVSADTAGPGRAVRTRGTGSTEQPRARPASAGLSTGAAVATGAAVTSVAAIAVSAAGEGALGTVEAAAARAAPATGTAGAAVTADAEPRRTGPPSPPLPPAVPVPPSPPATPAAEESAPSAPFRPAPPLPPLPPLPHAPMPKKSWA
>NC_015576.1|WP_041318640.1|3529506_3529716_+|hypothetical-protein
MSEVQPLPPSPNQSPPAWPFTLLSVPSAPLQIIPQKFSVNGAKIWLITPLTCDPKSELIQSCKSACSGM
>NC_015576.1|WP_041318643.1|3530197_3530641_-|50S-ribosomal-protein-L15
MTPIKLHDLRPAPGSKTKRTRVGRGEGSKGKTAGRGTKGTKARKNVPVRFEGGQMPIHMRLPKLKGFRNRFRTEYEVVNVGDINRLFPDGGAIGVDELVAKGAVRKNTLVKVLGDGKLTVKADVTAHKFSGSARDKITAAGGTATEL
>NC_015576.1|WP_013830241.1|3530640_3530829_-|50S-ribosomal-protein-L30
MANLKITQVRGTIGARWNQRESLRTLGLRKIRQSVVREDNPQTRGLIRVVHHLVEVEQAGEE
>NC_015576.1|WP_085975778.1|3530831_3531527_-|30S-ribosomal-protein-S5
MAEQPTGASSAGPDTGSAPRTDGRDNRDNRGGRGGRDGGRGGRDGRDGDKSNYLERVVAINRVSKVVKGGRRFSFTALVIVGDGKGMVGVGYGKAKEVPAAIAKGVEEARKSFFRVPLIRGTITHPVQGEAAAGVVLLRPASPGTGVIAGGAVRAVLECAGVHDILSKSLGSDNAINVVHATVAALKMLQRPEEVAARRGLPIEDVAPAAMLKARRESESLAASAAREGTA
>NC_015576.1|WP_013830243.1|3531573_3531981_-|50S-ribosomal-protein-L18
MAQSEAGTGARKPIGQSVSEARRTHRVRRHARLRKKIAGTPERPRLVVHRSSRHIHVQLVDDLAGHTLAAASSIEADVRGVDGDKKAHSVRVGQLIAERAKAAGVQTVVFDRGGYTYGGRIAALADAAREGGLKF
>NC_015576.1|WP_013830244.1|3531983_3532523_-|50S-ribosomal-protein-L6
MSRIGKQPVPVPAGVDVTIDGQNVSVKGPKGTLELTVAEPINVARNDDGAIVVTRPDDDRRNRSLHGLSRTLVANLITGVSEGYVRKMEIFGVGYRVALKGSDLEFALGYSHPVLIKAPEGITFAVETPTKFSISGIDKQKVGQISANIRRLRRPDPYKGKGVRYEGEQVRRKVGKTGK
>NC_015576.1|WP_013830245.1|3532536_3532935_-|30S-ribosomal-protein-S8
MTMTDPIADFLTRLRNANSAYHDEVTLPHSKIKANIAEILKREGYITDYHVEDARVGKALVVNLKYGPNRERSLAGLRRVSKPGLRVYAKSTNLPRVLGGLGVAIISTSSGLLTDRQAARQGVGGEVLAYVW
>NC_015576.1|WP_013830246.1|3532954_3533140_-|type-Z-30S-ribosomal-protein-S14
MAKKALINKAARKPKFAVRAYTRCNKCGRPRAVLRKFGLCRICLREMAHAGELPGVQKSSW
>NC_015576.1|WP_013830247.1|3533144_3533708_-|50S-ribosomal-protein-L5
MTTAEKIQPRLKVKYREEIRDALNNEFNYANVMQIPGVVKVVVNMGVGEAARDAKLINNAVSDLALITGQRPEIRKARLSIAQFKLREGMPIGARVTLRGDRMWEFLDRLTSIALPRIRDFRGLSPKQFDGSGNYTFGLAEQSMFHEIDVDSIDRPRGMNITVVTSATNDDEGRALLRALGFPFKEK

Crispr_ID: NC_015576_9

• CRISPR_ID: NC_015576_9
• CRISPR_location: 4154868-4154947
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_015576_9

Consensus_repeat	Method
CCGACGAAGGAGAGCCGAAGCTG	CRISPRCasFinder

spacers of NC_015576_9

>9.1|4154891|34|NC_015576|CRISPRCasFinder
GGACCGCCGCATCAACACCGCGGTTCAGCGAGGC

CRISPR arrays and Neighbor proteins around NC_015576_9

CRISPR arrays

The CRISPR arrays of NC_015576_9

>merge|NC_015576|9|4154868-4154947|CRISPRCasFinder
CCGACGAAGGAGAGCCGAAGCTGGGACCGCCGCATCAACACCGCGGTTCAGCGAGGCTCGACGAAGGAGAGCCGAAGCTG

>NC_015576|9|8|4154868-4154947|CRISPRCasFinder
CCGACGAAGGAGAGCCGAAGCTG	GGACCGCCGCATCAACACCGCGGTTCAGCGAGGC
TCGACGAAGGAGAGCCGAAGCTG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015576.1|WP_013830836.1|4151323_4152319_-|TerC/Alx-family-metal-homeostasis-membrane-protein	unknown	unknown	gnl|CDD|274743
NC_015576.1|WP_013830830.1|4146957_4147995_-|zinc-dependent-metalloprotease	unknown	unknown	gnl|CDD|274833
NC_015576.1|WP_013830845.1|4166617_4167973_+|M1-family-metallopeptidase	unknown	unknown	gnl|CDD|341066
NC_015576.1|WP_013830835.1|4150897_4151335_+|hypothetical-protein	unknown	unknown	gnl|CDD|211538
NC_015576.1|WP_013830841.1|4155226_4159744_-|cation-translocating-P-type-ATPase	unknown	unknown	gnl|CDD|319840
NC_015576.1|WP_013830848.1|4169692_4170886_+|PPE-domain-containing-protein	unknown	unknown	gnl|CDD|366325
NC_015576.1|WP_013830847.1|4169375_4169675_+|PE-family-protein	unknown	unknown	gnl|CDD|376422
NC_015576.1|WP_013830829.1|4146007_4146979_-|tRNA-lysidine(34)-synthetase-TilS	unknown	unknown	gnl|CDD|238950
NC_015576.1|WP_041318996.1|4162703_4166621_+|amino-acid-adenylation-domain-containing-protein	unknown	unknown	gnl|CDD|274093
NC_015576.1|WP_013830834.1|4150102_4150789_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|379115
NC_015576.1|WP_013830849.1|4170916_4171678_+|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|223816
NC_015576.1|WP_013830843.1|4160866_4162654_+|hypothetical-protein	unknown	unknown	unknown
NC_015576.1|WP_041318993.1|4145355_4145997_-|hypoxanthine-phosphoribosyltransferase	unknown	unknown	gnl|CDD|223707
NC_015576.1|WP_013830833.1|4149448_4149937_+|inorganic-diphosphatase	unknown	unknown	gnl|CDD|376376
NC_015576.1|WP_013830840.1|4155043_4155214_+|hypothetical-protein	unknown	unknown	unknown
NC_015576.1|WP_013830842.1|4159889_4160834_-|GDP-mannose-4,6-dehydratase	unknown	unknown	gnl|CDD|187566
NC_015576.1|WP_081465679.1|4152411_4153677_+|hypothetical-protein	unknown	unknown	gnl|CDD|240533
NC_015576.1|WP_013830846.1|4168086_4169352_+|PPE-domain-containing-protein	unknown	unknown	gnl|CDD|366325
NC_015576.1|WP_013830831.1|4147991_4149368_-|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase	unknown	unknown	gnl|CDD|200042
NC_015576.1|WP_013830838.1|4153812_4154502_+|glycosyltransferase-family-2-protein	unknown	unknown	gnl|CDD|133022

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015576.1|WP_013830836.1|4151323_4152319_-|TerC/Alx-family-metal-homeostasis-membrane-protein	gnl|CDD|274743	TIGR03718, R_switched_Alx, integral membrane protein, TerC family. Rfam model RF00080 describes a structured RNA element called the yybP-ykoY leader, or SraF, which may precede one or several genes in a genome. Members of this highly hydrophobic protein family often are preceded by a yybP-ykoY leader, which may serve as a riboswitch. From the larger group of TerC homologs (pfam03741), this subfamily contains TerC itself from Alcaligenes sp. plasmid IncHI2 pMER610 and from Proteus mirabilis. It also contains the alkaline-inducible E. coli protein Alx, which unlike the two TerC examples is preceded by a yybP-ykoY leader.	2.31789e-119
NC_015576.1|WP_013830830.1|4146957_4147995_-|zinc-dependent-metalloprotease	gnl|CDD|274833	TIGR03883, DUF2342_F420, uncharacterized protein, coenzyme F420 biosynthesis associated. A phylogenetic tree of the DUF2342 family (TIGR03624) consists of two major branches. One of these branches, modeled here, is observed almost entirely to be found in coenzyme F420 biosynthesizing species of the Actinobacterial, Chloroflexi and Archaeal lineages. The few organisms having genes within this family and lacking F420 biosynthesis may either have an undiscovered F420 transporter, or may represent F420-to-FMN revertants. This family includes a Chloroflexus Aurantiacus protein whose crystal structure has been determined (PDB:3CMN_A). This has been annotated as a putative hydrolase, but the support for that assertion is untraceable. There is no cofactor present in the structure.	5.19567e-143
NC_015576.1|WP_013830845.1|4166617_4167973_+|M1-family-metallopeptidase	gnl|CDD|341066	cd09603, M1_APN_like, Peptidase M1 family similar to aminopeptidase N catalytic domain. This family contains mostly bacterial and some archaeal M1 peptidases with smilarity to the catalytic domain of aminopeptidase N (APN; CD13; alanyl aminopeptidase; EC 3.4.11.2), a type II integral membrane protease belonging to the M1 gluzincin family. APN preferentially cleaves neutral amino acids from the N-terminus of oligopeptides and, in higher eukaryotes, is present in a variety of human tissues and cell types (leukocyte, fibroblast, endothelial and epithelial cells). APN expression is dysregulated in inflammatory diseases such as chronic pain, rheumatoid arthritis, multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, polymyositis/dermatomyosytis and pulmonary sarcoidosis, and is enhanced in tumor cells such as melanoma, renal, prostate, pancreas, colon, gastric and thyroid cancers. It is predominantly expressed on stem cells and on cells of the granulocytic and monocytic lineages at distinct stages of differentiation, thus considered a marker of differentiation. Thus, APN inhibition may lead to the development of anti-cancer and anti-inflammatory drugs. APNs are also present in many pathogenic bacteria and represent potential drug targets. Some APNs have been used commercially, such as one from Lactococcus lactis used in the food industry. APN also serves as a receptor for coronaviruses, although the virus receptor interaction site seems to be distinct from the enzymatic site and aminopeptidase activity is not necessary for viral infection. APNs have also been extensively studied as putative Cry toxin receptors. Cry1 proteins are pore-forming toxins that bind to the midgut epithelial cell membrane of susceptible insect larvae, causing extensive damage. Several different toxins, including Cry1Aa, Cry1Ab, Cry1Ac, Cry1Ba, Cry1Ca and Cry1Fa, have been shown to bind to APNs; however, a direct role of APN in cytotoxicity has been yet to be firmly established.	4.41237e-167
NC_015576.1|WP_013830835.1|4150897_4151335_+|hypothetical-protein	gnl|CDD|211538	TIGR00026, Hypothetical_protein_Rv1261c/MT1299/Mb1292c., deazaflavin-dependent oxidoreductase, nitroreductase family. This model represents a family of proteins found in paralogous families in the genera Mycobacterium and Streptomyces. Seven members are in Mycobacterium tuberculosis. Member protein Rv3547 has been characterized as a deazaflavin-dependent nitroreductase. [Unknown function, Enzymes of unknown specificity].	0.000345362
NC_015576.1|WP_013830841.1|4155226_4159744_-|cation-translocating-P-type-ATPase	gnl|CDD|319840	cd07539, P-type_ATPase, uncharacterized subfamily of P-type ATPase transporters. This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.	0
NC_015576.1|WP_013830848.1|4169692_4170886_+|PPE-domain-containing-protein	gnl|CDD|366325	pfam00823, PPE, PPE family. This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	4.77813e-56
NC_015576.1|WP_013830847.1|4169375_4169675_+|PE-family-protein	gnl|CDD|376422	pfam00934, PE, PE family. This family named after a PE motif near to the amino terminus of the domain. The PE family of proteins all contain an amino-terminal region of about 110 amino acids. The carboxyl terminus of this family are variable and fall into several classes. The largest class of PE proteins is the highly repetitive PGRS class which have a high glycine content. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	2.06162e-13
NC_015576.1|WP_013830829.1|4146007_4146979_-|tRNA-lysidine(34)-synthetase-TilS	gnl|CDD|238950	cd01992, PP-ATPase, N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This domain has a strongly conserved motif SGGXD at the N terminus.	5.41382e-52
NC_015576.1|WP_041318996.1|4162703_4166621_+|amino-acid-adenylation-domain-containing-protein	gnl|CDD|274093	TIGR02353, NON-RIBOSOMAL_PEPTIDE_SYNTHETASE, non-ribosomal peptide synthetase terminal domain of unknown function. This domain is found exclusively in non-ribosomal peptide synthetases and always as the final domain in the polypeptide. This domain is roughly 700 amino acids in size and is found in polypeptides roughly twice that size.	0
NC_015576.1|WP_013830834.1|4150102_4150789_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|379115	pfam13305, WHG, WHG domain. This presumed domain is around 80 amino acids in length. It is found to the C-terminus of a DNA-binding helix-turn-helix domain. This domain may be involved in binding to an as yet unknown ligand that allows a transcriptional regulation response to that molecule. The domain is named WHG after three conserved residues near the C-terminus of the domain.	7.12807e-10
NC_015576.1|WP_013830849.1|4170916_4171678_+|response-regulator-transcription-factor	gnl|CDD|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	6.67157e-87
NC_015576.1|WP_041318993.1|4145355_4145997_-|hypoxanthine-phosphoribosyltransferase	gnl|CDD|223707	COG0634, Hpt, Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism].	4.53011e-89
NC_015576.1|WP_013830833.1|4149448_4149937_+|inorganic-diphosphatase	gnl|CDD|376376	pfam00719, Pyrophosphatase, Inorganic pyrophosphatase.	1.85306e-85
NC_015576.1|WP_013830842.1|4159889_4160834_-|GDP-mannose-4,6-dehydratase	gnl|CDD|187566	cd05256, UDP_AE_SDR_e, UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs. This subgroup contains UDP-N-acetylglucosamine 4-epimerase of Pseudomonas aeruginosa, WbpP, an extended SDR, that catalyzes the NAD+ dependent conversion of UDP-GlcNAc and UDPGalNA to UDP-Glc and UDP-Gal. This subgroup has the characteristic active site tetrad and NAD-binding motif of the extended SDRs. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.51976e-116
NC_015576.1|WP_081465679.1|4152411_4153677_+|hypothetical-protein	gnl|CDD|240533	cd13128, MATE_Wzx_like, Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	0.000766861
NC_015576.1|WP_013830846.1|4168086_4169352_+|PPE-domain-containing-protein	gnl|CDD|366325	pfam00823, PPE, PPE family. This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	8.12383e-56
NC_015576.1|WP_013830831.1|4147991_4149368_-|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase	gnl|CDD|200042	TIGR00666, D-alanyl-D-alanine_carboxypeptidase_DacB, D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family. In E. coli, this protein is known as penicillin binding protein 4 (dacB). A signal sequence is cleaved from a precursor form. The protein is described as periplasmic in E. coli (Gram-negative) and extracellular in Actinomadura R39 (Gram-positive). Unlike some other proteins with similar activity, it does not form transpeptidation. It is not essential for viability. This family is related to class A beta-lactamases. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	9.19088e-94
NC_015576.1|WP_013830838.1|4153812_4154502_+|glycosyltransferase-family-2-protein	gnl|CDD|133022	cd04179, DPM_DPG-synthase_like, DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily. DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.	1.29624e-40

Protein sequences

>NC_015576.1|WP_013830838.1|4153812_4154502_+|glycosyltransferase-family-2-protein
MYPDVWIIVPAFGEAAVIGDVIAGIRSVFDAVVCVDDGSADDTAAIARRAGAHVVRHPVNLGQGAAIQTGVEFARSRPGARLFATFDADGQHRVADVLRMIERLDDDHLDIVIGTRFAAAEAAAAVPPLKRLVLRAAVWLNPRIRRLGLSDAHNGLRVFNRRVADRLDLTMTGMSHAGEIIALIAENRWRVGEEPVEVLYTDYSKSKGQPLLNGVNILFDGLLRKRMSR
>NC_015576.1|WP_081465679.1|4152411_4153677_+|hypothetical-protein
MGGTGPRRSTGGLPAGPVTRASVARVGTATLLSALCGYAVLYLAARDLDPAGFSVFSVFWGAFGLVAGAANGLLQETTREVRFAREVGTGRPSTRHTRPLWVAGLAGVVAAGLVAGTSPLWSGHVFVEARWLSVGLLCFGLANFAVHATLLGMLAGTNRWTQYGALMVTDAGIRVAVATATFAVGWGLVGFLWATVAGAMAWLLLLAASPAARSAARLLTPVGTTDFLRGAAHSITAAGASAILVMGFPVLLQATYGELGAQGGVVILAVTVTRAPLLVPLTALQGNLIAHFVDQRGRRLRALSIPAASVAAVGAAGAVAAGLVGPWLLRTVFGPDYHASGPLLAGLTAGATAIALLTLTGAATVAAALHRAYALGWVGATVVSTLLLMLPLELPTRTVVALLCGPLVGIAAHLTALRAAP
>NC_015576.1|WP_013830836.1|4151323_4152319_-|TerC/Alx-family-metal-homeostasis-membrane-protein
MDPSLLEWLVTVAGLSAVLGFDLFLVARRLHEPTIREVATRLTFYIGLAVAFGVWVWAHHGSKYGMQFFAGWLTEYSLSVDNLFVFVIIMNSFNVPKKYRQEALFVGIVLALSFRSVFIALGGVAAQRLSWTFYLFGAFMAYTAIKLLRHGDHVGDGGEGNNFVVRFARNHFNVTDRWAGVRFFVRDGAGAWAVTPMFLVALALGTTDLVFAMDSIPAIYGLTRQPYLVFAATVFALMGLRQLYFILGKLLNRFVYLSRGLALILGFIGVRMVLHALRTNEVWFINSGRNFNVPEIPTPASLAVVAGVLVLTTVASLYRTRGGAKAGGLPE
>NC_015576.1|WP_013830835.1|4150897_4151335_+|hypothetical-protein
MTTRYDRPSATARFGNALIRRLAEAGISVAGTRALTVRGRKSGELRGVVINLLSVDGVDYLVAPRGETEWVRNARAAGEVLLGPRWRRAPTRVTEVFDDDKPVVLRQYLRRWHWQVKGFMAGVTPDSDDDELRSAAPSIPVFSLG
>NC_015576.1|WP_013830834.1|4150102_4150789_-|TetR/AcrR-family-transcriptional-regulator
MGKRQEARERIEAKIIEVGRRQLLAHGAAGLSLRAVARDLGMVSSAVYRYVAGRDELLTLLVVDAYSDLADTVDRARSPGARWRDEIRVIGHAVRDWALAHPARWALLYGSPVPGYHAPAERTVVPGTRVIAAMLETVAAGIAAGDIPPTSQLATQPLSADSDRIRAEFGFIGDDGVIAKCLLLWAALVGAISLDVFGGYGADTLTRPRAVFDAQLSLLLGMLTQPQD
>NC_015576.1|WP_013830833.1|4149448_4149937_+|inorganic-diphosphatase
MQFDVTIEIPKGQRNKYEIDHATGRVKLDRYLYTPMGYPADYGFIEDTLGEDGDPLDAMVLLPQSVFPGVIVEARPVGMFRMTDEAGGDDKVLCVPAGDHRWDHIADIGDVPEYELDAIKHFFVHYKDLEPGKFVKAADWVGRAEAEAEITRSIERFKTSGH
>NC_015576.1|WP_013830831.1|4147991_4149368_-|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase
MDSTRWRHSSTHLGIAGAVLALAAAVVVVAAVVLPDESGAGAHVVAPAPTATAEPGVVPVVDDAPVPTGSALTAAMSAALADPNLGRLTGRITDALTGKALWTQQEDLPMQPASTNKVLTAAAALLALDLSTRVTTRVTAGDQPGVVVLVGAGDPTLSTAEVGQDTWYRDAARISDLADQVRRSGVTPTEVRVDVSAFSGPSMAPGWDPDDIEGGDIAPIEAVMVDGGRIQPTTVESRRSRTPALDAGEALAAELGLDADKVSIATASVTGRELGAVSSAPLVVRLGEMMNASDNVMAECIGREVAAAMGRPRSFAGAVDAVTNRLATAHIAVSGASLYDSSGLSVDNRLSARNLDAVVQAAAGPDQPELRPLLDMLPVAGGSGTLSDRFLDPRTGRGAAGWLRAKTGSLTRTNALAGIVTDRDRRVLTFAFISNDAGPTGRTSIDALAAVLRTCGCG
>NC_015576.1|WP_013830830.1|4146957_4147995_-|zinc-dependent-metalloprotease
MTEPDIGRAVDWGFAATVGRWLVRPAPPMTDYTRRQVIDDLHRSARAAEPLVREVTGLGADGPVPEARVIDRPQWIAAAADSMRVMTGGTETSVGFFSGRLAGAQTGALLAFVSSGILGQYDPFCAEDGHGTGLLLLVYPNVVAVERQLRVSPADFRLWVCLHEVTHRVQFSVNPWLADYMSTALGVLTGDGSPDLTQVVSRLADYVRGRRDEAGPSGILGLVRAVQSEDQRTALDQLLTLGTLLEGHADHVMDAVGPAAVPSVATIRNRFEERRQRSQPPLQRLLRALMGLDAKLSQYTRGKAFVDTVVGRVGMDRFNAVWSSPQHLPLPAEIEEPQQWIDRVL
>NC_015576.1|WP_013830829.1|4146007_4146979_-|tRNA-lysidine(34)-synthetase-TilS
MDRSGAVAGLRAALLAFAERHLPEVEPWCVALSGGPDSLALTAVAAQLRPTTALIVDHGLQAGSAQVAGRARSQAIELGCVDAQVIPVTVGGKGFRGGPEAAARTARYGALERARDRRPVLLGHTLDDQAETVLLGLGRGSGPRSLAGMRPHDPPWCRPLLGVRRAATREACTELALTPWLDPHNSDKRFTRVRLRLQVLPLLEDVLGGGVAEALARSATALRENTELIDALAEQAAPEVTAGAGLDTAGLAGLAGPVRRAVIRRWLLAGGGRGLTDLQIRAVDRLVTQWRGQGGVAVGSDLRGERLFAVRDDGVLRLRREPV
>NC_015576.1|WP_041318993.1|4145355_4145997_-|hypoxanthine-phosphoribosyltransferase
MVVARRAWHAVLVAVFSPGETPESYAGDIKSVLLTEQQIRARTAELGAQIAADYTDGSRPATQGESGDLLLITVLKGAVLFVTDLARAIPLPTQFEFMAVSSYGSSTSSSGVVRILKDLDRDISDRDVLIVEDVVDSGLTLSWLLRNLAARRPRSLRVCTLLRKPEAVRAGVDIAYVGFDIPNDFVVGYGLDYIERYRDLPYIGTLDPRIYQS
>NC_015576.1|WP_013830840.1|4155043_4155214_+|hypothetical-protein
MKATEVLAEPLAEVTATALTVPIVELYAVLWRAGVLDVEQRRSTRPAAAAPVLRSA
>NC_015576.1|WP_013830841.1|4155226_4159744_-|cation-translocating-P-type-ATPase
MDVFSIGRFGLETVGAAATSVLGASLDLAAIPLREGAKILAGERSDLTSRRSWRGAGRAWIEIRGLDEDGGADIGAEVLDALRARPDVTSVRLNRPLSRVIVEIDDDASLADLCATVGAVEKSAALSVTETAALPGDGLLLAAKGAMVGANAVGLAIATAGSVLRWPAAPKIFDAAASVARYQPLVRNALESRIGPARTDAVLSLASLGSHIITMSPAILAVDLMVEGLKASEARAGALAWNRYEPELARWAEHPEVPRAPRPVPRPHGPAERYLRRTAVAQVLATGVVGAITRNVDMTSSAILATSPKAVRTSCESFAATLGQGLADSHEVLPLRPDSLRRLDKIDTVVIDPRVLTGEQRRVVQIHGATEHELPQAWNNAQRLLDKPGLRPGWHRVRMTARDRAEAVEALILPTHHALASAVVLEGRASGAQLVTVDTDILGELRPGFDDIRPAPGAGDIDGMDAALAAAVTELQQAGRTVAVLSSSAAQALAAADLALGVMPASENDSLPPPFYADLLLADLGAAWQLLRALPAARDATERGVAISIGASTIAGLLLVRGVRATIPGLGAAPGRGPGPVTVGAGAGMLSGYLLARRVLRARAPQPAPAYEWHAMSVEQVRELLGPGAVTPLAERAPVDTGPQGMFWPYFHAVRAELSDPMTPILALCSAATAMLGSPIDAVMVGTVLTGNAMLAAYQRLRAESRLNTLLAQQAPPARIALTGADGSRTYHEIVAEQLLPGDVIEVRSNEVVPADARLIEQCDVEVDESSLTGESLSVGKQLDPTPGAELAERSSMLYAGTTVIAGTALAIVTAVGADTQSRRASELASGELPEVGLQHHLSQLMHRTFPYSAAGGVAVGALGLLRQGGLRVALGNAIAVAIAAVPEGMPLMATLAQHASSQRLSKSGALVRIPRSVEALGRVDVVCFDKTGTLSENRLRVTTVHPVGGYSDDDVLGTAAQAAPAPGGAAYAHATDQAIVEGAAAAAGARPWTEPDAHLPFRSGRAFSASALGSELVVKGAPEVVLEACKNAGAEEERQVAEMAARGLRVIAVAQRKLTAAQLRAVRDDPEGTERITEVAGSGLTLIGFLGLADTPRADAPQLLSDLAARGIDIRMITGDHPITASAIAAEMGVTVAAEQVITGSEWNALNRKEQERVVCERVIFARMSPENKVQIVQTLERAGRVSAMVGDGANDAAAIRAATVGLGVVAHGSDSAHATADVVLTDGKIGALVDAIDEGRRLWRGVQLAISGLLGGNAGEVMFSVIGTAVTGDSPLNTRQLLLMNTLTDALPATAVAVSTPAGPIGDAVPGLDEKKLWRAVAFRGGVTAAAGTAAWAMGRVSGTPQRASTVALISLVTTELGQTVVDSRAPLVLATAAGSFVLFAAMVSTPGVSQLLGCTPVGPIGWAQGVGTAAVATAAVAVAGRRSDVVKEIAAAVPEAPTVAAAPADKAVAAKKVPAKKGPAAKKPPAKKAPAAKKAAAKNASAKKAAAKKPTRKLEVVR
>NC_015576.1|WP_013830842.1|4159889_4160834_-|GDP-mannose-4,6-dehydratase
MRALVTGAAGFIGSSLVDRLRADGHPVVGLDNFATGRATNIEHLAGDADFSFVEADIVTADLADVLAQYRPEVIFHLAAQIDVRHSVADPAFDASVNVVGTIRLAEAARAAGVRKIVHTSSGGSIYGTPPRYPTTEDDPTDPASPYAAGKVAGEIYLNTFRHLYGLQCSAIAPANVYGPRQDPHGEAGVVAIFAQALLQGAPTKVFGDGSNTRDYVFVDDVVDAFVRASGPAGDGQRFNVGTGVETSDRQLHSAVAAAVGAPDDPEFHPPRLGDLKRSCLDVSRAREVLGWQPRVALADGVARTVSYFRQVKSA
>NC_015576.1|WP_013830843.1|4160866_4162654_+|hypothetical-protein
MRTRLASLPWVCWAALALIAAQLAVRAVVAFGGYFYWDDLILIGRAGTHELLSPSYLFDDHDGHVMPGAFLLAGVLSRLWPLQWAAPAASLVVLQLLASLALLRALRVILGWRPVLLVPLVFALFCPLGLPAFAWWAAALNSLPMCAALAWVCADAILLARTGNRRYALTGTVAYAGGLLFFEKAAVIPFVAFTVCALLHHVAGGRGAVAATWRAGARLWAATLAVTGGWIAVYLAVVNQRRWSLDLDMTRDLLWRSVTHGIVPSLAGGPWTWARWAPASPWALPGPAVMALGWLVLAGLLAVSSARKHRLVPVWLAAAGYAAACQVPIYLMRSSAFTALELAQTLRYLADLVVVLAILGAVGMCAPNRDASRWLDASPWRTAVVSCLAVTFTASSLYSTATFLARWRDDPARPYLHNALPALAAARVESDAPLLDQEVDPLVLQRVVYPENLASHLFALVRDRPEFASATPRLRMLTSAGTLTDAQVTWVRSIVAGPVPQCGYLVQPDLPVTLGLDGPLLPADWTAEINYLANVDGAMTLSLSDGPDVRVRVRPGLNRVYVRLPGGGHNVTARADTAALSVCIASGPLGYVAPT
>NC_015576.1|WP_041318996.1|4162703_4166621_+|amino-acid-adenylation-domain-containing-protein
MPTVQVPTQYLRASSAPEPRTLIDVLQETAARHPDAAAIDDGEVVLTYGELIADIEESVAWLAARGLGRGDRIGIRMPSGSYALYVAILAVLAAGAAYVPVDADDPAERAELVFTEAQVAAILTEQGLLRGPGESRGWRASAPSLRDDAWIIFTSGSTGTPKGVAITHRNAAAFVDAEAQLFLQDNPIGPGDRVLAGLSVAFDASCEEMWLAWRYGACLVPAPRSLVRSGMDLGPWLVSRDVTVVSTVPSLAALWPAEALEAVRLLIFGGEACPPELAARLAADGREVWNTYGPTETTVVACAAQLGESGPVRIGLPLAGWDLAVIGADGEPVATGEVGELVIGGVGLGRYLDADRDTEKFAPLPALEWPRAYRSGDLVRLEPDGLVFCGRADDQVKVGGRRIELGEVDSALLGLPGVSGAAAAVRSSAGGTPLLVGYLVSSDPDFDVAAARAMLERRLPAALVPRLVLVDELPTRTSGKVDRDALPWPVGPEPGGRWDADDPDSTLGWLAGLWREVLGTAVDDEQADFFALGGGSLQAAQLVVALRQRYPQTTVAQLYDRPRLGSLAGFLDDTGRSDPAAAAAPRPVQPMPRLTQAAQLLLSVPLATLTGLQWVTWLALLNNTAAAWHPLPWLVRLDWGWVIAAFVLFVTPLGRMGIAALGARALLAGLRPGSYRRGGAEHLRVWFAERLAAASGAENLAGAPWLVYYARALGNKIGKGVDLHSAPPVTGMLTLGHRCSIEPEVDLSGYWIDGEVFHVGPITIGNDATVGARTTLLPGASVGKDADVAPGSGVIGEVKKGQYWTGSPAVKSGKARHPWPDQRPPPRPIWVAVYGLTSILLGGLPLLALGAGLAVVGRAVGEAATLGAAIGPAALWTPAAALTALAGYAAVTIAAVRLLSIGLTEGYHPVRSRQGWQLWATERLMDAARDYLFPVYASLITPWWLRLLGAKVGDGTEISTALVIPKFTTIADGAFLADDTMVASYELGGGWIHVAPATIGKRAFLGNSGITQPGRRVPDKALVAVLSTAPHKAKAGSSWLGSPPVRLRRKMADLDAERTFEPPLRLKLMRAVMETFRLIPVMVTVAIGVTMLGVLQWAATRFGYGWTALGSGVALLAAGAAAGGIAVVAKWVTVGRIRATEHPLWSPFVWRNEVSDTFVETVAAPWFARAATGTPVMNLWLRALGATIGRGVWCETYWLPEADLVTLGPGATVNRGCVVQTHLFHDRIMQLDTVTLEAGATLGPHCVALPAARVGAGTTIGPASLVMRGDEVPPATRWQGNPIAPWPVPRKKRGSSPAPTEESAA
>NC_015576.1|WP_013830845.1|4166617_4167973_+|M1-family-metallopeptidase
MSKPVKPLTEATDSVAPVADPYLPGSGNTGYRVSRYELDLEYKLSSNRLSGTATITAVTLTALRELTLDLADTLSVAKVWVNGRHPARFGTAAAKLRITLAAELPAGAALVITVRYSGSPRPSETLWGEVGFEELSDGALVSGQPNGAPTWFPCDDQPAAKASYLIQISTDSSYRAVANGELVSQRVRSARTTWTYEQPEPTPTYLVTLQIGRYVTRRLPDADVPIHAVLPARLTRQFDRDFARQSQMMDLFVRLFGPYPLTAGYTVLVTDDELEIPLEAQGISVFGANHCDGRRGSERLIAHELAHQWFGNSVTVRHWRDIWLHEGFACYAEWLWSEHSGGPSTDELARRYHRQLSSLPQDLLLADPGPADMFDDRVYKRGALTLHLLRGKLGDDDFFALLREWTTRYRHGNAATEDFTGLAAEYAAAASVEPLEALWQAWLYSAELPAL
>NC_015576.1|WP_013830846.1|4168086_4169352_+|PPE-domain-containing-protein
MNFAALPPEVNSALMYSGAGSGPIRAAATAWKAMAAELETAATSYRSIITGLTDQTWQGPAATAMATAAAPYAAWMSTTATQAAHAGTQASAAAAAYETAFAMTVPPPVITANRTQLATLIATNILGQNTAAIAANEAHYAQMWAQDATAMYGYAGNAATATQLPTFTAPHTTTDAAPAADTSGDYQGAGAPGLVLDILVALLEVDSIAPFEGGGAGLEFGALAIEAASLAPFAGLGFGGDFGSIGGLGLIGGTVSAGGGFPPASLASAAAAPGRVPAACAGTGRAVPLGGLSVPQAWAAATPSVLRETTLVAAQSGVSTAAAAAGAEIPFAEMGLAGMAGRAMAGTVGLGRRTPVTAPNPITPAKPAESADVSRVAPEPVTGVEILAELRGLAELRDAGVLTEDEFTRQRERVIDDFIDE
>NC_015576.1|WP_013830847.1|4169375_4169675_+|PE-family-protein
MSFVVTQPESLSGAAGDLQGIGSAVHAQSAAVAAPTTAMAAPASDAVSMSIAALFNANGALFQDVAAQAAAVHQMFVSTLNGGGMAYASTEAANAIAAG
>NC_015576.1|WP_013830848.1|4169692_4170886_+|PPE-domain-containing-protein
MNFAALPPEVNSALMYAGPGSGPIRAAATAWKTMAAELETAANAYRTVIATLTDQTWQGPAATAMATAATPYLAWMNSTATQAATTGSQAATAAAAYETAFAMTVPPPVITANRTQLATLIATNLLGQNTAAIAANEAHYSAMWTQDATAMYGYAGNAATATQLPAYTAPGPTTTGAAPATPGAAITPGLAFDLAAAVLEVGSVVPFGSIGLGGAFGGMAITLGELALPEEGALGLGALGGLDLIGRTAPSGRGATWAGMGKSVPVGALSVPRTWAAATPAELREITLVTAQSGTSAAAAATAGAEIPFAEMGLAGMAGRNMTCTVVPGRRSAAAPPNPTIAPASPKPADESDDPDQPVRPKSIGVVAELRALVELRDSGVLSQQKFIERKERLLGE
>NC_015576.1|WP_013830849.1|4170916_4171678_+|response-regulator-transcription-factor
MSDNTDHRSPRKAILGQLPRINRPDGSPIRVLLVDDEPALTSLVTMALHYEGWVVDVAHNGRDAVAKFHSGEPDLLVLDIMLPDVDGLQILQRVRESDAYIPTLFLTARDSVTDRVTGLTSGADDYMTKPFSLEELVARLRGLLRRSAQLTPPVDEVLTVGDLTLDGASRQVTFGRTPVSLSTTEFELLRFLMRNPGRALARAEILDRVWNYDFAGRTSIVDLYISYLRKKIDADPPMIHTVRGVGYMLKPQP

Crispr_ID: NC_015576_10

• CRISPR_ID: NC_015576_10
• CRISPR_location: 4193344-4193555
• CRISPR_type: Unclear
• Repeat_type: NA
• Spacer_info: 1 spacers
• Cas_protein_info: cas3

Consensus repeat of NC_015576_10

Consensus_repeat	Method
CCCCCGGGCCGGTGGAGGTGAGGCGAAGCCGGGACCGACGCAGGAACCGGGG	CRISPRCasFinder

spacers of NC_015576_10

>10.1|4193396|108|NC_015576|CRISPRCasFinder
CGGTTCGGCGAGGCTCACTGGAGCCGGCCCCCGGGCCGGTGGAGGTGAGGCGAAGCCGGGACCGACGCAGGAACCGGGGCGGTTCGGCGAGGCTCACTGGAGCCGGCC

CRISPR arrays and Neighbor proteins around NC_015576_10

CRISPR arrays

The CRISPR arrays of NC_015576_10

>merge|NC_015576|10|4193344-4193555|CRISPRCasFinder
CCCCCGGGCCGGTGGAGGTGAGGCGAAGCCGGGACCGACGCAGGAACCGGGGCGGTTCGGCGAGGCTCACTGGAGCCGGCCCCCGGGCCGGTGGAGGTGAGGCGAAGCCGGGACCGACGCAGGAACCGGGGCGGTTCGGCGAGGCTCACTGGAGCCGGCCCCCCCGGGCCGGTGGAGGTGAGGCGAAGCCGGGACCGCCGCAGGAACCGGGG

>NC_015576|10|9|4193344-4193555|CRISPRCasFinder
CCCCCGGGCCGGTGGAGGTGAGGCGAAGCCGGGACCGACGCAGGAACCGGGG	CGGTTCGGCGAGGCTCACTGGAGCCGGCCCCCGGGCCGGTGGAGGTGAGGCGAAGCCGGGACCGACGCAGGAACCGGGGCGGTTCGGCGAGGCTCACTGGAGCCGGCC
CCCCCGGGCCGGTGGAGGTGAGGCGAAGCCGGGACCGCCGCAGGAACCGGGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015576.1|WP_013830869.1|4197022_4197976_+|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223669
NC_015576.1|WP_081465681.1|4189775_4190807_-|CpaE-like-family-protein	unknown	unknown	gnl|CDD|274798
NC_015576.1|WP_013830874.1|4201433_4201574_+|hypothetical-protein	unknown	unknown	unknown
NC_015576.1|WP_013830862.1|4188603_4189779_-|TadA-family-conjugal-transfer-associated-ATPase	unknown	unknown	gnl|CDD|200328
NC_015576.1|WP_013830864.1|4191270_4192128_+|HAD-IB-family-hydrolase	unknown	unknown	gnl|CDD|273654
NC_015576.1|WP_013830856.1|4185210_4186242_+|DUF5593-domain-containing-protein	unknown	unknown	gnl|CDD|376047
NC_015576.1|WP_081465590.1|4186238_4186907_-|hypothetical-protein	unknown	unknown	gnl|CDD|274799
NC_015576.1|WP_049792955.1|4196456_4197023_+|phage-holin-family-protein	unknown	unknown	gnl|CDD|377816
NC_015576.1|WP_085975736.1|4187225_4187810_-|type-II-secretion-system-F-family-protein	unknown	unknown	gnl|CDD|224975
NC_015576.1|WP_041319023.1|4187806_4188607_-|type-II-secretion-system-F-family-protein	unknown	unknown	gnl|CDD|227300
NC_015576.1|WP_041320327.1|4199980_4200598_-|TlpA-family-protein-disulfide-reductase	unknown	unknown	gnl|CDD|239264
NC_015576.1|WP_193374492.1|4200620_4201382_-|endonuclease-III	unknown	unknown	gnl|CDD|223255
NC_015576.1|WP_013830875.1|4201680_4202355_+|cAMP-activated-global-transcriptional-regulator-CRP	unknown	unknown	gnl|CDD|223736
NC_015576.1|WP_013830876.1|4202425_4203205_-|MBL-fold-metallo-hydrolase	unknown	unknown	gnl|CDD|293836
NC_015576.1|WP_013830870.1|4198002_4199196_-|acid-resistance-serine-protease-MarP	unknown	unknown	gnl|CDD|379142
NC_015576.1|WP_081465682.1|4199192_4199876_-|CoA-pyrophosphatase	unknown	unknown	gnl|CDD|239518
NC_015576.1|WP_013830865.1|4192546_4193293_-|hypothetical-protein	unknown	unknown	unknown
NC_015576.1|WP_049793064.1|4195587_4196235_-|peptidase	unknown	unknown	unknown
NC_015576.1|WP_041319019.1|4182555_4184910_+|DEAD/DEAH-box-helicase	cas3	mkCas0139_cas3_CAS-I	gnl|CDD|274800
NC_015576.1|WP_081465680.1|4186941_4187106_-|DUF4244-domain-containing-protein	unknown	unknown	gnl|CDD|379429

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_015576.1|WP_041319019.1|4182555_4184910_+|DEAD/DEAH-box-helicase	cas3	mkCas0139_cas3_CAS-I	1.9e-13	44.0	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015576.1|WP_013830869.1|4197022_4197976_+|alpha/beta-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.65359e-25
NC_015576.1|WP_013830862.1|4188603_4189779_-|TadA-family-conjugal-transfer-associated-ATPase	gnl|CDD|200328	TIGR03819, heli_sec_ATPase, helicase/secretion neighborhood ATPase. Members of this protein family comprise a distinct clade of putative ATPase associated with an integral membrane complex likely to act in pilus formation, secretion, or conjugal transfer. The association of most members with a nearby gene for a DEAH-box helicase suggests a role in conjugal transfer.	5.67089e-161
NC_015576.1|WP_013830870.1|4198002_4199196_-|acid-resistance-serine-protease-MarP	gnl|CDD|379142	pfam13365, Trypsin_2, Trypsin-like peptidase domain. This family includes trypsin-like peptidase domains.	7.94114e-17
NC_015576.1|WP_013830864.1|4191270_4192128_+|HAD-IB-family-hydrolase	gnl|CDD|273654	TIGR01490, Uncharacterized_protein_Rv3661/MT3761, HAD-superfamily subfamily IB hydrolase, TIGR01490. This hypothetical equivalog is a member of the IB subfamily (TIGR01488) of the haloacid dehalogenase (HAD) superfamily of aspartate-nucleophile hydrolases. The sequences modelled here are all bacterial. The IB subfamily includes the enzyme phosphoserine phosphatase (TIGR00338). Due to this relationship, several of these sequences have been annotated as "phosphoserine phosphatase related proteins," or "Phosphoserine phosphatase-family enzymes." There is presently no evidence that any of the enzymes in this model possess PSPase activity. OMNI|NTL01ML1250 is annotated as a "possible transferase," however this is due to the C-terminal domain found on this sequence which is homologous to a group of glycerol-phosphate acyltransferases (between trusted and noise to TIGR00530). A subset of these sequences including OMNI|CC1962, the Caulobacter crescentus CicA protein cluster together and may represent a separate equivalog. [Unknown function, Enzymes of unknown specificity].	4.24663e-77
NC_015576.1|WP_081465681.1|4189775_4190807_-|CpaE-like-family-protein	gnl|CDD|274798	TIGR03815, CpaE_hom_Actino, helicase/secretion neighborhood CpaE-like protein. Members of this protein family belong to the MinD/ParA family of P-loop NTPases, and in particular show homology to the CpaE family of pilus assembly proteins (see ). Nearly all members are found, not only in a gene context consistent with pilus biogenesis or a pilus-like secretion apparatus, but also near a DEAD/DEAH-box helicase, suggesting an involvement in DNA transfer activity. The model describes a clade restricted to the Actinobacteria.	4.2643e-74
NC_015576.1|WP_081465590.1|4186238_4186907_-|hypothetical-protein	gnl|CDD|274799	TIGR03816, tadE_like_DECH, helicase/secretion neighborhood TadE-like protein. Members of this small, highly hydrophobic protein family occur in a pilus/secretion-like region that usually is next to an uncharacterized DEAH-box helicase, in Actinobacteria. Members show sequence similarity to the TadE-like family described by pfam07811. The function is unknown. [Unknown function, General].	9.53481e-20
NC_015576.1|WP_013830856.1|4185210_4186242_+|DUF5593-domain-containing-protein	gnl|CDD|376047	pfam18621, DUF5628, Family of unknown function (DUF5628). This is a domain of unknown function found in Actinobacteria.	1.21457e-63
NC_015576.1|WP_085975736.1|4187225_4187810_-|type-II-secretion-system-F-family-protein	gnl|CDD|224975	COG2064, TadC, Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion].	4.37206e-07
NC_015576.1|WP_041319023.1|4187806_4188607_-|type-II-secretion-system-F-family-protein	gnl|CDD|227300	COG4965, TadB, Flp pilus assembly protein TadB [Intracellular trafficking and secretion].	9.06807e-31
NC_015576.1|WP_041320327.1|4199980_4200598_-|TlpA-family-protein-disulfide-reductase	gnl|CDD|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	1.64179e-24
NC_015576.1|WP_193374492.1|4200620_4201382_-|endonuclease-III	gnl|CDD|223255	COG0177, Nth, Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair].	7.35178e-102
NC_015576.1|WP_013830875.1|4201680_4202355_+|cAMP-activated-global-transcriptional-regulator-CRP	gnl|CDD|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	2.96838e-56
NC_015576.1|WP_013830876.1|4202425_4203205_-|MBL-fold-metallo-hydrolase	gnl|CDD|293836	cd16278, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily.Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	4.13598e-69
NC_015576.1|WP_049792955.1|4196456_4197023_+|phage-holin-family-protein	gnl|CDD|377816	pfam07332, Phage_holin_3_6, Putative Actinobacterial Holin-X, holin superfamily III. Phage_holin_3_6 is a family of small hydrophobic proteins with two or three transmembrane domains of the Hol-X family. Holin proteins are produced by double-stranded DNA bacteriophages that use an endolysin-holin strategy to achieve lysis of their hosts. The endolysins are peptidoglycan-degrading enzymes that are usually accumulated in the cytosol until access to the cell wall substrate is provided by the holin membrane lesion.	2.01394e-32
NC_015576.1|WP_081465682.1|4199192_4199876_-|CoA-pyrophosphatase	gnl|CDD|239518	cd03426, CoAse, Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative stress. CoAse has a conserved Nudix fold and requires a single divalent cation for catalysis. In addition to a signature Nudix motif G[X5]E[X7]REUXEEXGU, where U is Ile, Leu, or Val, CoAse contains an additional motif upstream called the NuCoA motif (LLTXT(SA)X3RX3GX3FPGG) which is postulated to be involved in CoA recognition. CoA plays a central role in lipid metabolism. It is involved in the initial steps of fatty acid sythesis in the cytosol, in the oxidation of fatty acids and the citric acid cycle in the mitochondria, and in the oxidation of long-chain fatty acids in peroxisomes. CoA has the important role of activating fatty acids for further modification into key biological signalling molecules.	3.54016e-49
NC_015576.1|WP_041319019.1|4182555_4184910_+|DEAD/DEAH-box-helicase	gnl|CDD|274800	TIGR03817, DECH_helic, helicase/secretion neighborhood putative DEAH-box helicase. A conserved gene neighborhood widely spread in the Actinobacteria contains this uncharacterized DEAH-box family helicase encoded convergently towards an operon of genes for protein homologous to type II secretion and pilus formation proteins. The context suggests that this helicase may play a role in conjugal transfer of DNA.	0
NC_015576.1|WP_081465680.1|4186941_4187106_-|DUF4244-domain-containing-protein	gnl|CDD|379429	pfam14029, DUF4244, Protein of unknown function (DUF4244). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 66 and 95 amino acids in length. There is a conserved EYA sequence motif.	1.66441e-14

Protein sequences

>NC_015576.1|WP_013830865.1|4192546_4193293_-|hypothetical-protein
MITDPLAPLLELPGVADASEKVRDELARAHRHKTNVRGWAVSAAEASLRAARASSVLDGGPTTVDARSTGDPVFAGALRVAQALEGGENSLVEVWRRAPLQALARLHVLAAADLVDEDHLGRPAGGGEVGRRLELLADLAAGGTRAPAPVFAAVVHGELLTLAPFGSADGVVARGAARLVTIASGLDRHGLGVPEVHWMRKAGAYRRAAQAFAGGSTEGVTEWLLLCCGALHAGALDALGIAEAGAKR
>NC_015576.1|WP_013830864.1|4191270_4192128_+|HAD-IB-family-hydrolase
MTASDPGTRQPQSQGSPRDTDSRTRTAAFLDLDHTIIAKSSALAFSKPFMDQGLINRRTVLKSSYAQFLMLLSGADHDQMERMRTHLTNMCTGWNVEQVKAIVNETMHDIVSPLVFAEAAELIADHKLCGRDVVVVSASGEEIVAPIARALGATHAMATRMVVADGKYTGEIAFYCYGEGKVQAIRELAAREGYPLEHCYAYSDSITDLPMLQAVGHPSAVNPDRALRKEAVANGWPVLTFSRPVSLRDRLPAPSGAAVATTAAVGISAVVAGALTYSLLRRRVF
>NC_015576.1|WP_081465681.1|4189775_4190807_-|CpaE-like-family-protein
MRDELARVAAAVGVRVIQLDATSVPSRKAWTAAAAIVVDEAAAARCSAARLPRRAHVIVVTGAQPGPASWQGAVAVGAQRVLTLPIDGDELVAELAEAAAAVRDGGRRGEVIAVIGARGGAGASLLATALAQRAGEALLVDLDPWGGGIDLLAGTENATGLRWCDLTAQTGRLTWPALRDALPRQRGVSVLSGARRGQQPGDVEAGTVDAVVEAGRRGGITVVCDLPRALTDPVETVLAAADLVVVVSPCDVRSCAAGAAIAPRLRAANPNVGLVVRGPAPGGLRAVEVAEITGLPLLATLRAEPRLAERLEHAALRLHRRSALAAAAGRVLDVLPARTALAA
>NC_015576.1|WP_013830862.1|4188603_4189779_-|TadA-family-conjugal-transfer-associated-ATPase
MRDSLIDRVRERLASESSAFSDLRPEAVAAAIRAESGGVLGDTEMLSNLRTLQTELTGAGILEPLLCAADTTDVLVTAPDAVWVDDGAGLRRTDIRFADEAAVRRLAQRLAAAAGRRLDDAQPWVDGRLGGIGTGEFTVRLHAMLPPVAADGTCLSLRVLRPATQDIAALAAAGGIARAAVALLADIVDARLAFLVSGGTGAGKTTLLSAMLGAVHPRERLVCVEDAPELQPRHPHLVRLVARAANVEGAGEVGLRDLVRQALRMRPDRLVVGEVRGAEVVDLLAALNTGHDGGAGTVHANSPAEVPARLEALAALGGLDRAGLHSQLAAAVQVLLHVGRERGGKRRLTDISVLRRTDTGLVQAAPVWQVDRGLSEHVAEFRALLRERTPA
>NC_015576.1|WP_041319023.1|4187806_4188607_-|type-II-secretion-system-F-family-protein
MTGPGIAALALAAAALLGGSPRGRLRPVDRRGQRGTRWAVLGLPAGCAALLAVVALPASGCLAGALAVGTAALRHHRRRRGRRAAAESRALEAALDVLVGELRIGAHPVRAFAAAAAETGHDSVAAGLRGVVARARLGADVVTGLRDAAGSSAMPSHWERLAAYWQLGGEQGLAVAALMQAAHSDITARQRFSAQAEAGMAGARASATILGCLPVLGVLLGQVIGARPVAFLLGGPGGVLSVVGVSLICAGLLWSDRITGRVGAAL
>NC_015576.1|WP_085975736.1|4187225_4187810_-|type-II-secretion-system-F-family-protein
MSAAAVLLAMAVLAAPSTVRARAGMPRPQQPVRHRLTPGGDALALAAGLEVFALCLTAGMPVSGAAAATARYAPPQLAEVLRRGADLLALGAEPGVAWSASPDRSAGALDPSTTAVLRLARRSGASGAALATGLVALAAQCRAEAAHQATAAAERAGVLIAGPLGLCFLPAFVCLGIVPVVAGLAGDVLRSGLL
>NC_015576.1|WP_081465680.1|4186941_4187106_-|DUF4244-domain-containing-protein
MLLAADESGMSTVEYAIGTIAAAAFGAILYTVVTGDSIVAALNRVIGRALNTKV
>NC_015576.1|WP_081465590.1|4186238_4186907_-|hypothetical-protein
MPAPARSRRRSRWRPWSRCWCCAWRGSARCPHSSAASTPPGRRPGWRRAAIRRRRRRWSGGSLPPVRRSGCTPTAASWSRRSPSGRRCCRAWWSALRRCRPPSRPGEAGAATVAAAAMVAVLLTVTGGGFLLGAAVIARHRAQSVADLAALAGAARIPLGPDAACEAAQRLARKMAVREIACAVDGLDLTVTVAVAVPGWRIGPARASARAGPVGEAPRAIG
>NC_015576.1|WP_013830856.1|4185210_4186242_+|DUF5593-domain-containing-protein
MAHDWLLVETLGGEPAVVAQGRQVKNLVPITQFLRRSPHLAAIRTAIAETMRTGQSLVSITPKHDRVIRTEPVVMSDGRVHGVHVWSGPADVEPPERPTPGPLKWDLTLGVATDTEESLANSGKDPTVEATHGRAFAEELPTRDFNPNENKVLALAIRAEPDKTICSSWDVTDFRGDTIRVGFVARTGWESGLGRREHLVARGMNWRGQLDGTVHRPDFLAQQILHGLAQPGVHRAMVDLIDWRLLKWLDDPCPFYDWRGTVDAPRVHPDDEARVARMTTDFTAGPATGVLRLRQSDGGWAPVHVTVNRIELEAGTYAGLIALRLPTDGELAEAGLDPPADAS
>NC_015576.1|WP_041319019.1|4182555_4184910_+|DEAD/DEAH-box-helicase
MTVNFGGELLAAALAGIEPGEDPLRHVADLPASPGQAGAWPDWAGDDVVGAFTGRGIERPWSHQLAAAELAHTGRHVVIGTGTASGKSLAYQLPVMAALAADPRARALYLSPTKALGHDQLRTAHTLTAAVPRLSEAAAAVAPIAYDGDSSAELRRFARERSRWVFSNPDMIHLSLLRNHARWAVFLRGLRFVIVDECHYYRGVFGSHVAMVLRRLLRLCARYTAPGAPGPTVIFASATTAAPGASAAALIGQPVAEVTQDGSPHGARTVALWEPALRGDMTGENGAPVRRAAGTEAARVMADLIAEGARTLTFVRSRRGAELTALAARTRLESVAPALADKVASYRAGYLAEDRRGLERALADGELYGLATTNALELGVDIAGLDAVVIAGFPGTVTSFWQQAGRSGRRGQTALIVLIARDDPLDSYLVHHPAALLDKPIEQVVIDPANPYVLGPQLLCAATELPLTVAEVAQLGAERVAENLVDDGLLRRRSEKYFPAPGLDPHHEVDIRGAAGGQVVIVEADTGRLLGNVDAGRAPATVHTGAVYLHQGESYLVDSLDTERRIAFVHAEDPGYATFAREITDIAVTGDGERAWFGPVSLGLMPVTVTRQIVGYLRRLPTGEVLDFVELELPPATLPTTAVVYTVTAEALADCGITEARIPGALHAAEHAAIGLLPLVASCDRGDIGGLSMALGPGSLGALPSVFVYDGYPGGAGFAQRGFRSAATWLAATVETIEGCECPHGCPSCVQSPKCGNGNDPLDKDGAVRVLRLVLDRLNGTGRH
>NC_015576.1|WP_049793064.1|4195587_4196235_-|peptidase
MAGLAAPAARVAADNKVVMGGGAGLVVDGDTMCTLTSIGHDNTGALIGFTSAHCGGPGAQVAAEGSESNGTIGLMVAGNDNLDYAVIEFDPEKVTPVSNFGGFIIGGIGPDPSFGQIACKQGRTTGNSCGVTWGPGQDPGTIVMQVCGRPGDSGGPVVVNNMLVGMIHGAFSEALPTCVVKYIPLHTPAVVVSINAVLGDINANNRPGAGFVPIG
>NC_015576.1|WP_049792955.1|4196456_4197023_+|phage-holin-family-protein
MSKADRRRASRASTRSARADRNGVPNTLATIPLTDPHALPADPSLGELVKDATAQMSTLVRAEVELARAEITRDVKKGLTGSVFFIAALVVLFYSTFFFFFFLAEVLNIWLQDWAAYLIVFGVMLTVASGLALFGFLRVRRIRGPRQTIESVRETREALRPDPDRLHSSGPQSLKAHDGKPATDPSGW
>NC_015576.1|WP_013830869.1|4197022_4197976_+|alpha/beta-hydrolase
MPPPDPSITRIDGPWRHQDIHANGIRFHVVEAIPAGEDAADGPPMARPLVMLLHGFGSFWWTWRHQLRGLTGVRVVAVDLRGYGGSDKPPRGYDGWTLAGDTAGLIRALGHSSATLVGHADGGLVCWATALLHPRLVRAIALVSSPHPAALRNSALTRADQGRALLPWLLRYQLPFWPERSLTRRDGAEIERLVRSRAGANWQAGEDFSETIGHLRTAIQIPAAAHSALEYQRWAVRSQLRSEGRRFMKALDLRTLHIPLLHLRGDDDPYVLADPVAKTRRYAPQGRYVSLPGVGHFAHEEAPDQVNEQLMRFLSSS
>NC_015576.1|WP_013830870.1|4198002_4199196_-|acid-resistance-serine-protease-MarP
MTSSQWLDIAVLAIAFVAAVSGWRSGALGSLLSFVGVALGAMAGVLLAPHLIEHVAGARLKLFAALFLILAMVVIGEVAGVVLGRAVRGAIRSPGVRGVDSIVGVVLQLVVVLIAAWLLATPLTASDQPSLAAAVNDSRVLRQVDDLAPGWLKNVPRRLSAVLDDSGLPAVLEPFNRTPIAAVDAPDPGLAASPVVEATAPSVLRIRGVAPNCQKVLEGTGFVISPNRVMTNAHVVAGSDSVSVESGTKSYDATVISFDPKEDISILAVPDLPLPPLPFAPSPAEPDTDALVLGYPGGGVFEATPARVRDTINLEGPDIYRTTTVTRRVYTIRGTVQQGNSGGPMIDMEGRVLGVVFGAAVDDADTGFVMTAEEVSNQLARIGDTAPVSTQTCVGGE
>NC_015576.1|WP_081465682.1|4199192_4199876_-|CoA-pyrophosphatase
MPNAYQRRLPADIRRMVTAANAEADITGHGRDAAVLVLFSGPPSQQAGDIPESADLLVTVRASTLRHHAGQAAFPGGAVDPDDSGPVATALREANEETGIDPHRVHPLAVLQKVFIAPSGFQVVPVLAYSEDPGPVSVVDPAETAVVARVPLRAFINPANRLMVYRDARSRRWAMPAFRLNEMLVWGFTAQVISAMLDVAGWAQPWDDTEVRGLDEAMALVGGEGGI
>NC_015576.1|WP_041320327.1|4199980_4200598_-|TlpA-family-protein-disulfide-reductase
MSRSTWWTLAVLAVATALVAALVIELRREPVRPDRGAPVPAVAQDLTVLRERAGLPPCRDASDGAGPAALRGVTVACAADGAPVDVAAMFAGRRVVLNLWAYWCRPCRDELPAFAEYQRRAGPDVTVVTVHQDDNQAAGLALLAELGVRLPTLQDGRRQVAAALRVPNVMPATVVLAMDGSVARILPQSFATADEIAAAVGGSGR
>NC_015576.1|WP_193374492.1|4200620_4201382_-|endonuclease-III
MSEVTVDKAARAARTETRIGLVRRARRMNRTLAQAFPDAHCELDFTTPLELAVATVLSAQCTDVRVNLTTPALFARYPAALDYAQADRTELEELIRPTGFYRNKATSLIKLGQALVERYDGELPDTMDELVRLPGVGRKTANVILGNAFGVPGITVDTHFGRLVRRWDWTAEEDPVKVEHAVGELIERKEWTLLSHRVIFHGRRVCHSRKPACGVCVLARDCPSFGLGPTDRLEAAALVRGPETEHLLALAGL
>NC_015576.1|WP_013830874.1|4201433_4201574_+|hypothetical-protein
MSWLLITAIPALLMLAAVGLERIETGLSEAEATNPQFPRTRRANRV
>NC_015576.1|WP_013830875.1|4201680_4202355_+|cAMP-activated-global-transcriptional-regulator-CRP
MDEILARAGIFQGVEPSAVAALTKQLQPVDFPRGHTVFAEGEPGDRLYIIVSGKVKIGRRSPDGRENLLTIMGPSDMFGELSIFDPGPRTSSATTITEVRAVSMDRDALRSWISDRPEIAEQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQRFGTQEGGALRVTHDLTQEEIAQLVGASRETVNKALADFAHRGWIRLEGKSVLISDSERLARRAR
>NC_015576.1|WP_013830876.1|4202425_4203205_-|MBL-fold-metallo-hydrolase
MSLSHPAYGRLRPVTETASVLLADNPGLMTLEGTNTWVLRGPRSDEVVIVDPGPDDDEHIGRLAELGKVALVLISHRHFDHTDGIDKLADSLDVPVYSAGSGFQRRLGGGLIDGQVIEAADLRITVLATPGHTADSLSFVLDDAVLTADTVLGRGTTVIDTEDGDLAHYLDSLHRLRGLGQRTVLPGHGPELPNIDAVTAGYLAHREQRLDQVRSALAELGEDATTRQVVEHVYTDVDEELWDAAEWSVQAQLDYLRAT

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_015576_9	9.1|4154891|34|NC_015576|CRISPRCasFinder	4154891-4154924	34	NC_015576.1	1547549-1547582	0	1.0
NC_015576_9	9.1|4154891|34|NC_015576|CRISPRCasFinder	4154891-4154924	34	NC_015576.1	1653934-1653967	0	1.0
NC_015576_9	9.1|4154891|34|NC_015576|CRISPRCasFinder	4154891-4154924	34	NC_015576.1	1653991-1654024	1	0.971
NC_015576_9	9.1|4154891|34|NC_015576|CRISPRCasFinder	4154891-4154924	34	NC_015576.1	3167076-3167109	1	0.971
NC_015576_9	9.1|4154891|34|NC_015576|CRISPRCasFinder	4154891-4154924	34	NC_015576.1	3167133-3167166	1	0.971
NC_015576_2	2.1|69659|23|NC_015576|CRISPRCasFinder	69659-69681	23	NC_015576.1	69611-69633	2	0.913
NC_015576_9	9.1|4154891|34|NC_015576|CRISPRCasFinder	4154891-4154924	34	NC_015576.1	1037488-1037521	2	0.941
NC_015576_9	9.1|4154891|34|NC_015576|CRISPRCasFinder	4154891-4154924	34	NC_015576.1	1826836-1826869	2	0.941
NC_015576_9	9.1|4154891|34|NC_015576|CRISPRCasFinder	4154891-4154924	34	NC_015576.1	2125324-2125357	2	0.941
NC_015576_9	9.1|4154891|34|NC_015576|CRISPRCasFinder	4154891-4154924	34	NC_015576.1	3167019-3167052	2	0.941
NC_015576_10	10.1|4193396|108|NC_015576|CRISPRCasFinder	4193396-4193503	108	NC_015576.1	4193317-4193424	48	0.556

1. spacer 9.1|4154891|34|NC_015576|CRISPRCasFinder matches to position: 1547549-1547582, mismatch: 0, identity: 1.0

ggaccgccgcatcaacaccgcggttcagcgaggc	CRISPR spacer
ggaccgccgcatcaacaccgcggttcagcgaggc	Protospacer
**********************************

2. spacer 9.1|4154891|34|NC_015576|CRISPRCasFinder matches to position: 1653934-1653967, mismatch: 0, identity: 1.0

ggaccgccgcatcaacaccgcggttcagcgaggc	CRISPR spacer
ggaccgccgcatcaacaccgcggttcagcgaggc	Protospacer
**********************************

3. spacer 9.1|4154891|34|NC_015576|CRISPRCasFinder matches to position: 1653991-1654024, mismatch: 1, identity: 0.971

ggaccgccgcatcaacaccgcggttcagcgaggc	CRISPR spacer
ggaccgccgcatcaacacagcggttcagcgaggc	Protospacer
****************** ***************

4. spacer 9.1|4154891|34|NC_015576|CRISPRCasFinder matches to position: 3167076-3167109, mismatch: 1, identity: 0.971

ggaccgccgcatcaacaccgcggttcagcgaggc	CRISPR spacer
ggagcgccgcatcaacaccgcggttcagcgaggc	Protospacer
*** ******************************

5. spacer 9.1|4154891|34|NC_015576|CRISPRCasFinder matches to position: 3167133-3167166, mismatch: 1, identity: 0.971

ggaccgccgcatcaacaccgcggttcagcgaggc	CRISPR spacer
ggagcgccgcatcaacaccgcggttcagcgaggc	Protospacer
*** ******************************

6. spacer 2.1|69659|23|NC_015576|CRISPRCasFinder matches to position: 69611-69633, mismatch: 2, identity: 0.913

ggttccgctggtgcctgctgtgg	CRISPR spacer
ggttccgctggtgctggctgtgg	Protospacer
**************. *******

7. spacer 9.1|4154891|34|NC_015576|CRISPRCasFinder matches to position: 1037488-1037521, mismatch: 2, identity: 0.941

ggaccgccgcatcaacaccgcggttcagcgaggc	CRISPR spacer
ggaccgccgcatgaacacagcggttcagcgaggc	Protospacer
************ ***** ***************

8. spacer 9.1|4154891|34|NC_015576|CRISPRCasFinder matches to position: 1826836-1826869, mismatch: 2, identity: 0.941

ggaccgccgcatcaacaccgcggttcagcgaggc	CRISPR spacer
ggaccgccgcacgaacaccgcggttcagcgaggc	Protospacer
***********. *********************

9. spacer 9.1|4154891|34|NC_015576|CRISPRCasFinder matches to position: 2125324-2125357, mismatch: 2, identity: 0.941

ggaccgccgcatcaacaccgcggttcagcgaggc	CRISPR spacer
ggaccgccgcatcaacacagcggttcagcaaggc	Protospacer
****************** **********.****

10. spacer 9.1|4154891|34|NC_015576|CRISPRCasFinder matches to position: 3167019-3167052, mismatch: 2, identity: 0.941

ggaccgccgcatcaacaccgcggttcagcgaggc	CRISPR spacer
ggagcgccgcatcaacacagcggttcagcgaggc	Protospacer
*** ************** ***************

11. spacer 10.1|4193396|108|NC_015576|CRISPRCasFinder matches to position: 4193317-4193424, mismatch: 48, identity: 0.556

cggttcggcgaggctcactggagccggcccccgggccggtggaggtgaggcgaagccggg	CRISPR spacer
cggttcggcgaggctcactggagccggcccccgggccggtggaggtgaggcgaagccggg	Protospacer
************************************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_015576_2	2.1|69659|23|NC_015576|CRISPRCasFinder	69659-69681	23	AY078382	Pseudomonas aeruginosa phage PaP3, complete genome	38196-38218	2	0.913
NC_015576_2	2.1|69659|23|NC_015576|CRISPRCasFinder	69659-69681	23	MG432151	Pseudomonas phage Delta, complete genome	37454-37476	2	0.913
NC_015576_1	1.1|69344|26|NC_015576|CRISPRCasFinder	69344-69369	26	NZ_CP012748	Paraburkholderia caribensis MBA4 plasmid unnamed, complete sequence	245377-245402	5	0.808
NC_015576_3	3.1|225051|33|NC_015576|CRISPRCasFinder	225051-225083	33	NZ_CP044425	Paracoccus pantotrophus strain DSM 2944 plasmid pPAN2, complete sequence	443056-443088	5	0.848
NC_015576_7	7.1|3120372|28|NC_015576|CRISPRCasFinder	3120372-3120399	28	NZ_AP017296	Nostoc sp. NIES-3756 plasmid pNOS3756_1, complete sequence	197609-197636	5	0.821
NC_015576_3	3.1|225051|33|NC_015576|CRISPRCasFinder	225051-225083	33	ASHF01000034	Streptomyces sp. GBA 94-10 plasmid pGBA1, complete sequence, whole genome shotgun sequence	101336-101368	6	0.818
NC_015576_7	7.1|3120372|28|NC_015576|CRISPRCasFinder	3120372-3120399	28	NZ_CP016452	Sinorhizobium sp. RAC02 plasmid pBSY16_1, complete sequence	1808777-1808804	6	0.786
NC_015576_9	9.1|4154891|34|NC_015576|CRISPRCasFinder	4154891-4154924	34	NC_010474	Synechococcus sp. PCC 7002 plasmid pAQ7, complete sequence	90119-90152	8	0.765
NC_015576_3	3.1|225051|33|NC_015576|CRISPRCasFinder	225051-225083	33	NZ_CP021805	Sinorhizobium meliloti strain T073 plasmid psymA, complete sequence	148369-148401	9	0.727
NC_015576_9	9.1|4154891|34|NC_015576|CRISPRCasFinder	4154891-4154924	34	CP017041	Propionibacterium sp. oral taxon 193 strain F0672 plasmid unnamed1, complete sequence	19600-19633	10	0.706
NC_015576_9	9.1|4154891|34|NC_015576|CRISPRCasFinder	4154891-4154924	34	NZ_CP043437	Enterobacter sp. LU1 plasmid unnamed	235146-235179	10	0.706

1. spacer 2.1|69659|23|NC_015576|CRISPRCasFinder matches to AY078382 (Pseudomonas aeruginosa phage PaP3, complete genome) position: , mismatch: 2, identity: 0.913

ggttccgctggtgcctgctgtgg	CRISPR spacer
ggttcggctggtggctgctgtgg	Protospacer
***** ******* *********

2. spacer 2.1|69659|23|NC_015576|CRISPRCasFinder matches to MG432151 (Pseudomonas phage Delta, complete genome) position: , mismatch: 2, identity: 0.913

ggttccgctggtgcctgctgtgg	CRISPR spacer
ggttcggctggtggctgctgtgg	Protospacer
***** ******* *********

3. spacer 1.1|69344|26|NC_015576|CRISPRCasFinder matches to NZ_CP012748 (Paraburkholderia caribensis MBA4 plasmid unnamed, complete sequence) position: , mismatch: 5, identity: 0.808

tacgccagcgggaagcgggtttttgc	CRISPR spacer
tcgcgcatcgggaagcgggtttttgc	Protospacer
*    ** ******************

4. spacer 3.1|225051|33|NC_015576|CRISPRCasFinder matches to NZ_CP044425 (Paracoccus pantotrophus strain DSM 2944 plasmid pPAN2, complete sequence) position: , mismatch: 5, identity: 0.848

---gcgccggacgcgaactgggcgccggatccgtcg	CRISPR spacer
tttgcgcc---cgcgaactgggcgccgaatgcgtcg	Protospacer
   *****   ****************.** *****

5. spacer 7.1|3120372|28|NC_015576|CRISPRCasFinder matches to NZ_AP017296 (Nostoc sp. NIES-3756 plasmid pNOS3756_1, complete sequence) position: , mismatch: 5, identity: 0.821

ggtgttgatgcggcggtcccagcttcac	CRISPR spacer
gattctgatgcggcggtttcagcttcac	Protospacer
*.* .************..*********

6. spacer 3.1|225051|33|NC_015576|CRISPRCasFinder matches to ASHF01000034 (Streptomyces sp. GBA 94-10 plasmid pGBA1, complete sequence, whole genome shotgun sequence) position: , mismatch: 6, identity: 0.818

gcgccggacgcgaactgggcgccggatccgtcg	CRISPR spacer
gcgccggacgcgaacggggcgccgtccccctcc	Protospacer
*************** ********  .** ** 

7. spacer 7.1|3120372|28|NC_015576|CRISPRCasFinder matches to NZ_CP016452 (Sinorhizobium sp. RAC02 plasmid pBSY16_1, complete sequence) position: , mismatch: 6, identity: 0.786

ggtgttgatgcggcggtcccagcttcac	CRISPR spacer
ggtgttgatgcggcgttcccaggccgag	Protospacer
*************** ****** .. * 

8. spacer 9.1|4154891|34|NC_015576|CRISPRCasFinder matches to NC_010474 (Synechococcus sp. PCC 7002 plasmid pAQ7, complete sequence) position: , mismatch: 8, identity: 0.765

ggaccgccgcatcaacaccgcggttcagcgaggc	CRISPR spacer
ccaccgccgcatcatcaccgaggttcagcaaatt	Protospacer
  ************ ***** ********.*. .

9. spacer 3.1|225051|33|NC_015576|CRISPRCasFinder matches to NZ_CP021805 (Sinorhizobium meliloti strain T073 plasmid psymA, complete sequence) position: , mismatch: 9, identity: 0.727

gcgccggacgcgaactgggcgccggatccgtcg	CRISPR spacer
gaaggcgacgcgaacggggcgccgcatccgcag	Protospacer
* .   ********* ******** *****. *

10. spacer 9.1|4154891|34|NC_015576|CRISPRCasFinder matches to CP017041 (Propionibacterium sp. oral taxon 193 strain F0672 plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.706

ggaccgccgcatcaacaccgcggttcagcgaggc	CRISPR spacer
ggaccgcggcatcaacgccgcggtcagccccgct	Protospacer
******* ********.*******. . *  * .

11. spacer 9.1|4154891|34|NC_015576|CRISPRCasFinder matches to NZ_CP043437 (Enterobacter sp. LU1 plasmid unnamed) position: , mismatch: 10, identity: 0.706

ggaccgccgcatcaacaccgcggttcagcgaggc	CRISPR spacer
gatgaaccacatcaataccgcggttcagcgcgct	Protospacer
*.   .**.******.************** * .

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	2974330 : 2981367	7	Bacillus_phage(33.33%)	NA	NA
DBSCAN-SWA_2	4290854 : 4300487	13	Mycobacterium_phage(57.14%)	NA	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>NC_015576|2974330:2981367|DBSCAN-SWA
GCTACAACATGCAGCTGACGCAGCCCTCCACCTCAGTGCCCTCCAGTGCCATCTGCCGTAGCCGGATGTAGTACAGCGTCTTGATTCCCTTGCGCCAGGCGTAGATCTGCGCGCGGTTCACGTCGCGGGTGGTGGCGGTGTCCTTGAAGAACAGCGTCAGGCTCAGCCCCTGGTCCACGTGCTGGGTGGCCGCGGCGTAGGTGTCGATGATCTTCTCGTAGCCGATCTCGTAGGCGTCGGAGTAGTACTCCAGGTTGTCGTTGGTCATGTACGGCGCCGGGTAGTAGACCCGGCCGATCTTGCCTTCCTTGCGGATCTCGATCTTCGACACGATCGGGTGGATCGACGACGTCGAGTGGTTGATGTAGGAGATCGACCCGGTCGGCGGAACCGCCTGCAGGTTCTGGTTGTAGATCCCGTGGGCGGCCACCGATTCCTTCAGCCGCTGCCAGTCGCTCTGTTCCGGGATCCGGATACCGGCGTCGGCGAAGAGCTGCCGCACCCTGACGGTCTTGGGCTCCCACACCTGGTTGATGTACTTGTCGAAGAACTCCCCGGACGCGTACTTGGACTTCTCGAAACCTACGAAGGACCTACCTCGTTCCAGCGCAAGACGATTCGATGCCCGCAGCGCGTGATACAGCACGGTATAGAAGTAGATGTTGGTGAAGTCGATGCCCTCTTCGGAGCCGTAGTGGATGCTCTCTCGGGCCAGGTAGCCGTGCAGGTTCATCTGGCCCAGCCCGATGGCGTGCGACTCGTTGTTGCCGTGCTCGATCGAGGGCACTGAGTTGATGTGGGTCTGGTCCGACACCGCGGTCAGCGCCCGGATGGCGACCTCGATGGTCTGGCCGAAGTCCGGGGAGTCCATCGCCTTGGCGATGTTGAGCGAGCCCAGGTTGCAGGAGATGTCCTTGCCCACCTTGGCGTAGCTCAAGTCGTCGTTGTACTCCGACGGAGTAGAGACCTGCAGGATCTCCGAGCACAGGTTCGAGTGGGTGATCTTGCCGGCAATGGGATTAGCTCGATTGACCGTATCTTCGAACATCACGTACGGGTAACCGGACTCGAACTGCAGCTCGGCCACAGTCTGGAAGAACTCGCGTGCCTTGATCTTGGTCTTGCGGATGGCCGAGTTGTCGACCATCTCGTAGTACTTCTCGCTGACCGAGATGTCGGCGAACGGGACGCCGTAGACCCGTTCGACGTCATACGGCGAGAACAGGTACATGTCCTCGTTCTTCTTGGCCAGCTCGAAGGTGATGTCGGGAATCACCACGCCCAGGCTCAGCGTCTTGATCCGGATCTTCTCGTCGGCGTTCTCCCGCTTGGTGTCCAGGAACCGGTAGATGTCGGGGTGGTGGGCGTGCAGGTAGACCGCGCCGGCTCCCTGGCGGGCGCCGAGCTGGTTGGCGTAGGAGAACGAGTCCTCCAGCAGCTTCATGATCGGGATGACCCCGGAGGACTGATTCTCGATGTTCTTGATCGGGGCGCCGTGTTCACGAATGTTGGTCAGCAGCAACGCCACTCCGCCGCCACGCTTGGACAGCTGCAGCGCGGAGTTGATCGAGCGGCCGATCGACTCCATGTTGTCCTCGATGCGCAGCAAAAAGCAGCTGACCGCCTCGCCGCGCTGCTTCTTACCGGAGTTCAGGAACGTCGGGGTGGCGGGTTGAAAACGGCCGTCGATGATCTCGTCGACCAGTTGCTCCGCCAGCTTGGTGTCGCCGGCGGCCAGCGTCAGCGCGACCATGCACACCCGGTCCTCGAAGCGTTCCAGATAGCGCTTGCCGTCGAAGGTCTTCAGCGTGTAGGAGGTGTAGTACTTGAACGCGCCCAAAAATGTCGGGAACCGGAACTTCTTGGCGTAGGCGCGATCCAGCAGCGACTTGACGAAGTTGCGCGAGTACTGGTCGAGCACCTCGCGCTCGTAGTAGTCCTTCTGGATCAGGTAGTCGAGCTTCTCGTCCTGATTGTGGAAGAACACCGTGTTCTGGTTGACGTGCTCCAAGAAGTACTGACGGGCCGCCAGCACATCCTTGTCGAACTGGATCTTTCCGTCGCTGTCGTACAGGTTGAGCATCGCGTTGAGCGCGTGGAAGTCCAGCTCGCCCACCGGAGCGCTGCGGGTGGTTGCTGTTACCTGCTCTGCAGTTGCAGCGGTAGGTGGCATGCCTCGTCCTTCCAGAAATCGGCTAAGCCCGCGCGGACGGCTTTCACGTCCTCGTCGGTTCCCATCAATTCGAATCGGTATAGGTACGGCACCCCGCACTTGCGGGCGACCACGTCGCCCGCGTAGCAGAACTCCGCACCGAAGTTGGTGTTGCCGGCGGCGATCACGCCGCGCAGCAGGTTCCGATTGTGTTCGTTGTTCAAAAAGGCGATGACCTGCTTGGGTACGTAGCCACCCGCGGTGTCATCGGTGATGTTGGGTGTGCCGCGGCCCCCGCCGTAGGTCGGCAGCACCAGCACGTAGGGGTGGTCCACCTCGATGCGCCCGTGCAGCGGAATCCGGATGGCCGGCAGCTGCAGCTTCTGCACGAAGCGGTGGGTGTTCTCCGACACCGAGGAGAAATACACCAGGCTGCACTCGACATCCGCAGACACGGCGACCCCCTTCAGCTCTCAGTCAGACTCCACCCGTACCCGATGCGGCGGCCGCTTACGCGCTCAGCGCGGTCTGCGCCAGCGCCTTGATGCGGTCCGGACGGAAACCCGACCAGTGCTCGTCGCCGGCGACGACGACCGGGGCCTGCAGGTAACCCAGCGCCATCACGTAGTCCCGCGCATCGGAGTCGAGGCTGATGTCCACGACCTCGTAGGCGATGCCTTGATTGTCCAGCGCCTTGTAGGTGGCGTTGCACTGCACGCATGCGGGCTTGGTGTAGACGGTGATGCTCATGGGCGCAGACTCCTCAGCGAATCGTCGGCAACGAACAGATGACGGATCAGGTACTACTTTCAGCGGGCCGCCAAGGCCTTGGATCTCCGGCCTCCACCGCAGCTCCGGGCAGTGATTCGATGCCCTTCGCCGCAGTTCGGCCAGCCCGATGATCCGGGGTCTGGCGGTGCTTGAAACACTACACCTAGTGGGTCGCCTTGAGAAGCCATACAAGATGTTCCGAACAACATTCTTGAAATTCGCAGGTTGTAAGCCTGTCGCCGTTGCCGCCTCGGCGTGTCGCACGTCACAAAAATTCCCGCGCTGCCCCATGGCGACAGGTCTACCACCGATCACCGACGACCACGCCCCGACACCGGACCCGCGTCCGGTTTCAGCAAAGACTTCGCCGGTGGCGCTCAGCCCGCCTGGACCGCCAGTTTGGCTACGACATCACGCACGGCGGACACCAGCTGCGCGTGCTCGCGGGGATGCTTTCCCTCCAGCATGCCTATCGGCACCGACAGCTTGATCTCATCGACCACTCGCGGCCCGGCGAGGCCGAAGGACTTGCGGGTCTCGTCGTGGGCCCACACTCCGCCATACCGGCCCAGCGCCGCACCGATCACCGCCAGCGGCTTTCCCTTGAGCGCACTGTCGCCGAACGGGCGCGACAGCCAGTCGATGGCGTTCTTGAGCACGCCGGGGATGGTGCCGTTGTACTCCGGGGTGACCACCAGGGCCGCGTCGGCGGCGGCGGCCGCCGCCCGGAGGGCGGTCACCCCCGCCGGCACGGTCGCTGGCGTGTCGAGGTCCTCGTTGTAGAACGGCAGCTCGCCAAGTCCCTCGCAGACCGCCACGCGGACACCTGCCGGGGCGGCCTCGGCCGCCAACTGCGCGATCTGGCGGTTGACCGATGCCGTGCGCAGGCTGCCGACCAACGCCAATACCGTGATCTCGCGGCTCACCTCGTCACGGATTTTTGCGAGGGCAGCAGGGCCCGGCTGAATACCCGGTTGGCCTGGCGCATCGCCGCGCTGTAGGGCAGCCAGGCCAGCCGCTTGAACGCATACAGCGCCCGGATGTCACCGGAGGTGTAGACCAGGTAGCGGTTGCGGGCCACCCCGGCCAGGATCTTCTCCGCGGCCTTCTCCGGCGACACGGCGTGGCCGGCGAACCGGCCCACCCATTTCTCCACCTGCGGGTCCTCGCGGTCGACGCCGGCGATCTCGACGGTGTTGACCAGCCCGGTCTTGACCGCACCGGGCACCACCACCGACACCCCGATGCGGTGTCGGGCCAGGTCGAAGCGCAGCACTTCCGATACCCCGCGCAGCCCGTACTTGCTGGCGCTGTAGGCGGCATGCCAGGGCAGCGCGACCAGCCCGGCGGCCGAGGAAACGTTGACCAGGTGCCCGCCGCGGCCCGCGGCGACCATCGGCGGCAGGAACGTCTCGATGACGTGGATGGGGCCCATCAGGTTGATGTCGACCATCTTGCGCCACTGCTCGTGGGTCAACCGGTCGACGGTCCCCCAGGCCGACACGCCCGCGATGTTCATCACGACGTCCATCGGCTCGTGCCGGGAATGGATGTCGGCGGCGAACGCGGCGACGTCGTCGTAGTCGGCGATGTCGATCACCCGGTGTTCGGGGACCTGGGCTCCCAGGGCGCGCGCGTCGGCGACGGTTTCGGCCAGTCCTTCGGCGTTGCGGTCGGTCAGATACAGCTCGGCGCCGGCCTCGGCGAGCCGTAACGCGGTGGCCCGGCCGATGCCGCTCGCCGCTCCGGTGATGAAGCACCGCTTGCCCCGGTAGTACTGCGCCACGCCTGTCATGGGTGCAGACCCTACCGTCCGGGTCGCGGCACCGGCGGCCGATGATTCAACCCCGCGCTGCGTCCCCGCCCCACAGCGCGGTGAGCCACAGCGCCTCGAGCACCCGTACCCCGCGCCCCACGTCACCGTCGGTCCCCAGGAATGCGGTGTCCCCGGACAGCATGTAGCCCGTGGTGGCAGCCAGTGTCCGCACCAGGGCGGGGATGTCTTCGCTGATCGGATCCGCAGTGCCCGCGGCGATCTCGTCGTTGACCACGCCGACGATCTGGTGGATCACCGCGTCGATCTGGGCGTCGAGCAGTTCCCGGATCTCGGCGTCGCTGTTGCGTGCCATGTTGCACGCCGACATCACCGGATCGTTGTGGGCAAAGACCGCCGCCGCGCTGCCCACCATGCGTTCGGCGAATGCCGCCGGCGATTCCTCGGCGCCGCGCGGCGCGAAGTACTGGGTCAGTTCTTCGAGCTCCTGGCTCGCCTCGGCGAGGATGTGCGCCAGTACGGCGTATTTGGAATCGAAGTAGAAATAGAAGCCCGACCGTGCCACCCCGGCCCGGTCGCTGATGGTGCTGACGGACAGCTCCGCGAACGGTTTTTCCTCCAGTAACTCCCGCACTGCCTGCACGATCGCCTGGCGTTGCTTGTCCCCCCGCCGCAGCGGCAGATCGTCGGGAGTCGGGCCGGCCGGGTCGTGCTGGGTGCTCACCCTTGCACCTTGCACCACGCCGCGCCGTATTCAAACTTGACACCCGTCAATTTTGATCTGAAGATGTGGTTACGTGACGGTCGCCACAGACCGTCATAGCCGCTGCGCACCTGACGTCCGCGAACGAGAGGTAGTCATCCGATGACCACCATGACCACCCCGCAGTATCTCCTCGACCAGGCCCGGCGCCGGTTCACCCCGACGCTGAACACCATCCCCGGGATGGGCGCCATCGAGAAGCGGCTGCTCACCGTGGACTGGAAGCAAAAGACGCTGGCGGAGCCCCCGGCCGGTAGCGGGCTCAAGCCGATCGTCGGCGACTCCGGGCTGCCGGTGTTGGGCCACATCGTCGAGATGTTCCGGGGCGGCCCGGACTTTGCGATGCACATCTACCGTAAGCACGGTCCGGTGTACTTCGCCGAATCGCCGATCCTGTCCTCGGTCGTCGCGCTGGGTCCCGACGCCACCGAGACCGTCTTCGCCAACCGCAAGAAGGACTACTCCACCACCGGGTGGATCCCGGTGATCGGCCCGTTCTTCAACCGCGGGCTGATGCTGCTGGACTTCGAGGAGCACTTGGCGCACAAGCGGATCATGCAGGGTGCGTTCACCCGCCCGCGGCTGGCCAGCTACGTCGAGGACATGGACCGGGTCGCCAGCGCGCTGGTGGCGAAATGGCCCACCAACGACCCCCGATTCCTGTTCTACCCGGCGGTCAAGGAATTGACGCTGGATGTGGCCTCGGTGGTGTTCATGGGCATGGACCTGCGTGACGACCAGAAGACCGTGGCGAAGGTCAACCACGCATTCGAGCAGACCACCCGGGCCGGCGGCGCGATCATCCGCACGTCGGTGCCACCGTTCAAGTGGTGGCGCGGTCTGCAGGGCCGCAAGGTACTCGAGGACTACTTCACCCAGCGGGTGCGCGAGCGCCGCAACGTCGAGGGCACCGACATGCTGACGGTGTTGTGCCACACCGCCGACGAGGATGGCAACACCTTCAGCGACGCCGACATCGTCAACCACATGATCTTCTTGATGATGGCCGCCCACGACACCACGACCTCGACCCTGACCACCATGGCCTACCACCTGGCGGCCAACCCGGAATGGCAGGAACGGGCGCGCGAAGAGTCGGCGCGGCTCGGCGACAGCCCGCTGGACATCGAGGCGCTGGAAAAGCTGGAGACCCTCGACCTGGTGATGGACGAGTCGCTGCGGCTGGTCACCCCGCTGCCGTTCAACATGCGCCAAGCCGTGCGCGACACCGAGTTGCTCGGGCACTACGTTCCGGCCGGGACGAACGTCACGCTGTGGCCGGGGATGAACCACTGGCTTCCCGAGTTATACACCAACCCGCGCCAGTTCGACCCCGAACGGTTCCTGGAGCCGCGTTCGGAGCACAAGAAGCACCGCTATGCGTTCGCACCGTTCGGCGGCGGAGCGCACAAGTGCATCGGGATGGTTTATGGGCGGCTGGAAGTCAAGACCGTCATGCACCGGCTGCTGCGCCGCTACCGGCTGGAGCTGTCGCGGCCCGGCTACCGACCGAAGTGGGACTACGCCGGCATGCCGCTGCCGATGGACGGCATGCCGATCGTGTTGCGCCCGATCTGA

Protein sequences of DBSCAN-SWA_1

>NC_015576|2974330:2981367|2977629_2978190_-|WP_041318356.1|DBSCAN-SWA
MRDEVSREITVLALVGSLRTASVNRQIAQLAAEAAPAGVRVAVCEGLGELPFYNEDLDTPATVPAGVTALRAAAAAADAALVVTPEYNGTIPGVLKNAIDWLSRPFGDSALKGKPLAVIGAALGRYGGVWAHDETRKSFGLAGPRVVDEIKLSVPIGMLEGKHPREHAQLVSAVRDVVAKLAVQAG
>NC_015576|2974330:2981367|2978174_2979047_-|WP_013829720.1|DBSCAN-SWA
MTGVAQYYRGKRCFITGAASGIGRATALRLAEAGAELYLTDRNAEGLAETVADARALGAQVPEHRVIDIADYDDVAAFAADIHSRHEPMDVVMNIAGVSAWGTVDRLTHEQWRKMVDINLMGPIHVIETFLPPMVAAGRGGHLVNVSSAAGLVALPWHAAYSASKYGLRGVSEVLRFDLARHRIGVSVVVPGAVKTGLVNTVEIAGVDREDPQVEKWVGRFAGHAVSPEKAAEKILAGVARNRYLVYTSGDIRALYAFKRLAWLPYSAAMRQANRVFSRALLPSQKSVTR
>NC_015576|2974330:2981367|2976468_2976936_-|WP_013829717.1|DBSCAN-SWA
MSADVECSLVYFSSVSENTHRFVQKLQLPAIRIPLHGRIEVDHPYVLVLPTYGGGRGTPNITDDTAGGYVPKQVIAFLNNEHNRNLLRGVIAAGNTNFGAEFCYAGDVVARKCGVPYLYRFELMGTDEDVKAVRAGLADFWKDEACHLPLQLQSR
>NC_015576|2974330:2981367|2979093_2979750_-|WP_013829721.1|DBSCAN-SWA
MSTQHDPAGPTPDDLPLRRGDKQRQAIVQAVRELLEEKPFAELSVSTISDRAGVARSGFYFYFDSKYAVLAHILAEASQELEELTQYFAPRGAEESPAAFAERMVGSAAAVFAHNDPVMSACNMARNSDAEIRELLDAQIDAVIHQIVGVVNDEIAAGTADPISEDIPALVRTLAATTGYMLSGDTAFLGTDGDVGRGVRVLEALWLTALWGGDAARG
>NC_015576|2974330:2981367|2979891_2981367_+|WP_013829722.1|DBSCAN-SWA
MTTMTTPQYLLDQARRRFTPTLNTIPGMGAIEKRLLTVDWKQKTLAEPPAGSGLKPIVGDSGLPVLGHIVEMFRGGPDFAMHIYRKHGPVYFAESPILSSVVALGPDATETVFANRKKDYSTTGWIPVIGPFFNRGLMLLDFEEHLAHKRIMQGAFTRPRLASYVEDMDRVASALVAKWPTNDPRFLFYPAVKELTLDVASVVFMGMDLRDDQKTVAKVNHAFEQTTRAGGAIIRTSVPPFKWWRGLQGRKVLEDYFTQRVRERRNVEGTDMLTVLCHTADEDGNTFSDADIVNHMIFLMMAAHDTTTSTLTTMAYHLAANPEWQERAREESARLGDSPLDIEALEKLETLDLVMDESLRLVTPLPFNMRQAVRDTELLGHYVPAGTNVTLWPGMNHWLPELYTNPRQFDPERFLEPRSEHKKHRYAFAPFGGGAHKCIGMVYGRLEVKTVMHRLLRRYRLELSRPGYRPKWDYAGMPLPMDGMPIVLRPI
>NC_015576|2974330:2981367|2974330_2976502_-|WP_041318353.1|DBSCAN-SWA
MPPTAATAEQVTATTRSAPVGELDFHALNAMLNLYDSDGKIQFDKDVLAARQYFLEHVNQNTVFFHNQDEKLDYLIQKDYYEREVLDQYSRNFVKSLLDRAYAKKFRFPTFLGAFKYYTSYTLKTFDGKRYLERFEDRVCMVALTLAAGDTKLAEQLVDEIIDGRFQPATPTFLNSGKKQRGEAVSCFLLRIEDNMESIGRSINSALQLSKRGGGVALLLTNIREHGAPIKNIENQSSGVIPIMKLLEDSFSYANQLGARQGAGAVYLHAHHPDIYRFLDTKRENADEKIRIKTLSLGVVIPDITFELAKKNEDMYLFSPYDVERVYGVPFADISVSEKYYEMVDNSAIRKTKIKAREFFQTVAELQFESGYPYVMFEDTVNRANPIAGKITHSNLCSEILQVSTPSEYNDDLSYAKVGKDISCNLGSLNIAKAMDSPDFGQTIEVAIRALTAVSDQTHINSVPSIEHGNNESHAIGLGQMNLHGYLARESIHYGSEEGIDFTNIYFYTVLYHALRASNRLALERGRSFVGFEKSKYASGEFFDKYINQVWEPKTVRVRQLFADAGIRIPEQSDWQRLKESVAAHGIYNQNLQAVPPTGSISYINHSTSSIHPIVSKIEIRKEGKIGRVYYPAPYMTNDNLEYYSDAYEIGYEKIIDTYAAATQHVDQGLSLTLFFKDTATTRDVNRAQIYAWRKGIKTLYYIRLRQMALEGTEVEGCVSCML
>NC_015576|2974330:2981367|2976991_2977231_-|WP_013829718.1|DBSCAN-SWA
MSITVYTKPACVQCNATYKALDNQGIAYEVVDISLDSDARDYVMALGYLQAPVVVAGDEHWSGFRPDRIKALAQTALSA

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_041318353.1|2974330_2976502_-	class 1b ribonucleoside-diphosphate reductase subunit alpha	V9VI16	Lactococcus_phage	2.2e-207	51.3
WP_013829717.1|2976468_2976936_-	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	J9PTY0	Bacillus_phage	1.1e-10	32.8
WP_013829718.1|2976991_2977231_-	redoxin NrdH	V5UN81	Mycobacterium_phage	3.7e-20	63.0
WP_041318356.1|2977629_2978190_-	NAD(P)H-dependent oxidoreductase	A0A2P0ZL77	Lactobacillus_phage	1.1e-09	36.2
WP_013829720.1|2978174_2979047_-	SDR family oxidoreductase	W8CYX9	Bacillus_phage	1.1e-05	35.9
WP_013829721.1|2979093_2979750_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_013829722.1|2979891_2981367_+	cytochrome P450	H2EFH0	Moumouvirus	4.1e-08	21.8

Sequences of DBSCAN-SWA_2

Nucleotide sequences of DBSCAN-SWA_2

>NC_015576|4290854:4300487|DBSCAN-SWA
TTCAGACGGCCGGCTTGAGGACATACCCGGCGCCGCGCAGCGTGTGGATCATCGGCTCTCGACCGTTGTCGATCTTCTTGCGCAGATAGGAGATGTAGAGCTCGACGATGTTGGCCCGGCCGCCGAAATCGTAGTCCCACACCCGATCGAGGATCTGCGCCTTGGACAGCACCCGCCTGGCGTTGTGCATCAGGTAGCGCAGCAGCTCGAATTCGGTGGACGTCAAGGTGATCGGGTCCCCGCCGCGCGTCACCTCGTGGGAGTCCTCGTCGAGAACCAGGTCGCCGACCACGATCTGCGCCCCGGCCTCGGCGGTGCTGACCCCGGTGCGCCGCAGCAGCGCCCGCAACCGCAACACCACCTCTTCGATGCTGAACGGCTTGGTGACGTAGTCGTCGCCGCCGGCGGTCAGCCCGGCGATGCGGTCCTCCAGCGCGTCCTTGGCGGTCAGGAACAGCACCGGCAACCGCGGGTTGATCTCCCGCAGTTTGCGCAGTACGTCCAGCCCGCTCATGTCCGGCAGCATCACGTCGAGCACCACCACGTCGGGGCGTTCGGCTTTGGCCGCGGCGATCGCCGAGGCGCCGTCGCCCGCGGTCGCGGTGGTCCAGCCCTCGTAGCGCAGTGCCATCGACACCATCTCGGCCAGCACCGTCTCGTCGTCCACCACCAGCACGGTGATGGGCTTGCCGTCGGCGCGCGCCATCACGACACGTTCCACCGATCCCCGTGGCGCAGTCATCGCGTTCCAGTATGTCGCCGGCGATGGGTCTTCCCTGTATCGACACTATGGCGGCGCTGTGAACCGATATCGTCGGTGCATGGCCCGCACCCCGCAGGAGATCTTCGACCACCACCTCCACGCACTGATCGCCCGCGACGTCGACGACTTGCTGGTCGACTACACCGACGACTCGGTGCTGATCACCGCGGCCGGCGTCGCAACAGGCCTCGACGGCATCAGGGCGGCGTTCAGCCAGCTCTCGGATGCGCTGGCCGCCGCGGTGTTCGACATCAAGTCGAAGACCTACCACGACGAGATCCTGCTGCTGGAGTGGACGCTGGACTCGCCGGGGTTCCAGGTCGACGGCGTGGACACCTTCGTGTTCGGCGAGGACTCGATCCGGGTGCAGACCATCTCCCAGCTGGTACGCCCCAAGGGCTGAACACCGCATGGATCTGGAACCGGTAGCGCAGTGGATGTCCGACCGGCAGCTCGGCGAAGGCCCGCTGTCCGACGTCACGGAACTGTCCGGCGGCACCCAGAACGTGATGCTGCGTTTCACCCGCTCGGGCCGCAGCTATGTGCTGCGACGCGGGCCGCTGCATCTGCGCCCGCGCAGCAATGACGTGATGCTGCGGGAGACCCGGGTGCTGGCCGCGCTGGCCGACACCGACGTACCGCACCCGGGATTGATCGCGGTCTGCGATGACCCTGCAGTGCTCGGAGACGCGGTGTTCTACCTGATGGAGCCGATCGACGGGTTCAACGCCAGCGGTGAGCTGCCCGAGTTGCATGCCAACGACCCCGCGGTGCGCTACGAGATGGGGCTGTCGATGGCCGACGCGCTGGCCAAGCTCGGTGCGGTCGACCATGTCGCGGTGGGGCTGGCCGACTACGGAAAGCCGGACGGCTTCCTGGAACGCCAAGTGCCGCGGTGGCTTTCCGAGCTGGACTCCTACCGGCAGTTCGAGAACTACCCCGGGCCCGAGCTGCCCGGCCTGGACGAGGTCGCCGGCTGGCTGCAGCGCAACGTGCCGGCGTCGTGGCAGCCCGGCATCCTGCACGGCGACTACCACGCGGCCAACGTGCTGTTCTCCCCCACCGGGCCGCAGGTCGCGGCGATCGTGGACTGGGAGATGTCGACCATCGGGGATCCGCTGCTGGACCTGGGCTGGCTGCTGGCCACCTGGCGCCAGGACGACGGATCCAGCGTGTTCAGCCACACCCTGACCGGGATGGACGGGCTGGCCTCCACCGACGATCTGGTGCAGCGGTACGCCAACGGCAGCTCCCGCGACCTGTCGCACATCGGCTGGTATGAGGTGATGGCGAGCTTCAAGCTGGCCATCGTGATCGAGGGAACACTGGCGCGGGCGTCGGCGGGCATGGCCCAGCAGGACGTCGGTGACCAACTGCACGAGGCCGCGGTGTGGCTGTTCGAGCGGGCGCAGACCCTGATAGCGAGCAAGACATGACCGGTCACCTCGACGAGATCGACCGGATCGTTGCGGCCGACACCTTCCGACTGGTCGACATCTTCAAGGATCTGCACCGCAACCCCGAGTTGGGCTTCGAAGAGGTGCGCACCGCGCGGATCGTCGCGCAGGCGCTGGGCAACCTCGGATTCACGGTGACCACCGGCATCGGCCGCACCGGTGTGGTGGCCGTGTTGGCCAACGGCCCGGGCCCGGTGGTGATGTATCGAGCGGACATGGACGCGCTGCGGGTGCCGGAGGCCACTGGCCTGGACTACGCCAGCAGCGACCCCTCGCTGGGGCACATGTGCGGCCACGACGCGCATGTGACCTGGATGCTGGGAATGGCCAAGGTGCTCGCCGAGACCACCGCTTCGTGGTCGGGAACCGCGGTGCTGATCGGTCAGCCGGCCGAAGAGCTGATCGCCGGGGCCCGGGCCATGGTCGACGACGGCCTCTACGACGTGGCCCCGCCCCCGGACTCCTTCATCGCCATGCACACCGTGCCGGTCCCGGTGGGCATGGTGGCCGCCGCGGGCGGTGAGCGGATGGCCGGCACCGACCAGCTCGAGATCGTGTTCCACGGCGTCGGCGGACACGGGTCGCTGCCGCAACTGGCCAAGGACCCGGTGCTGATGGCCGCCCAGGCCGTCGTGCAGTTCCAGGGCATCATCAGCCGCAGCATCGCCCCGAGCGAGGGCGCCGTGCTCACCGTGGGCTCGGTACAGGCCGGCACCACCTATAACGTCATCCCGGACCAGGCCCGGCTGTTGGCCAACCTGCGCTGGTACAACCCGGAGGTCCGCGAGCAACTGCTCGCCGGGATCCGAGCGATCAGCGAGGGCATCGCCCACAGCTTCGGCTTGCCCGATGCGCTGATGCCCGTCATCACCATGGGCGGCGGTTCCACCCCGCTGGTCAACGACGCGGATCTGACCGGGCGGCTGGCCGCCACCCTGCGCGATGCGCTCGGGGAGCACAACGTCATCACCGAGCTGCCCGAGGTCTCGGCATCCGAAGACTGCCACCTGCTCAAGGGGCCGCACCGCGACGTGCCGCTGGCCTATTTGATGGTGGGTGTCGCCGATCCGCAGGTGTACGCCGAGGCAGCCGCCCGCGGTCAGCTGTTCCCCTACACCCCGCACTCGCCCGACTACGTCGTCGACCTCGCCGCGATCCCGTTGGGCGCCCGGATCGCAAGCCGAGCGATGCTCGAGCTACTGGCGACCAGTTAGGTTACGAGACTGTTTCCATACTTCCGTTATGATCAAATGGTTGTGCAGTCTACGAATCCGAGCTAAGGTTTATTGCTGTGGACGATCGTCACAAAGACCCAACCGTGGTGCTGCCCTACCTTGTCGGCAGGCCGCTTGGAGCGACCGAGGTCTACGAGGCATTCGGTTATCGCAAGTCGGCCTATTACAAGGCGGCGCATGAGGGCCGGCTTATCAGTGCCGACAATCTGATCCGGGTTGCCAGGTACTTCGGGTTGAACCCCGTTGACCTGCAGGTCCGGTTCGGATTGATCGAGCATGATGCCGTCACCGAATATCTGGAATCGTCGTCGCGGCCGCTGCGCCTCGGTGATCTCAAAGCGGATCTGGACAAACCGCCGGTCTAAGCGGACTCACGGGAAGTACCGTCGACGCATGACGTCGGCCTTCATCGGTGCCACCGTGCTGGTGGCGCTCTACAGCCTGTGGGTGCGCCGCGAAACCTGGTGGTCGCGCTGGGAGATCGGCATCACGCTGGCGATCGCGCTGGAGGTCTGCGCATTGGTGCTGATGTCACCGTGGGCGTCCGCAGTGCTGGGGCCTACGATGCACAGCGTCACCCGGATATGGAACGTCCAGCAGTTGGTCGGTCACATCTGCTTCATCGTGGCGATCGCGGCCAACATCTATCACGTCCTGCCCCGGCTGGCGGATTTCGGCCGGGTCCGGCCGCTGTTCCGCCGACACGTGCAATGGCCCGTGCGGCTCGGTCTGGTGGCGTTGGTGGCGGTTTTCATCACCGCCGACGCCGATTACCGCCCGGACGGTCTGTCGACCGGCAACGACACCGGCGCCTGGGCCGAGATCTACTGGCTGCTGTTCTGCGGAATGCTGATCTACCTCTCCGGCTACGCGACACGGCTGCTGCTGCTGGTGCGATCCGATCCCCGGGCCCGGGAGACCGTGGAGCTCTACACCGCCTCGGCGGCGTTTGCGCTGGCCGGCCTGGTGGCACAGTTGAGCACCACCTGGACCAACGCCGATGCCAGCCAACTGGTCTGGCCGTGCGCATGCATCTCCGTGGTCATCTTCGCCTACGGCTCTGCCCGCTCGTGGCAGGCGAAGGCGGCGTGGTTCGCCGCCCGCACTCGACCGGTCAAGGAGCCCAACCCGCCGCCAGCGCTTTCGTGAGAGCGTGTGATGACGTCGGGATTCATCGCCGCCACGTTGGCGCTCATCGCTTACAGCTCTTGGATACGCCGCGATACCTGGTGGTCGCGGTGGGAGGTTGCCGCCTCGCTCGCGCTGGTGCTGGAAGGTGCTGCACTGCTGTTGATGTCGCCGTGGGGCGCCCCCGTGTTCGGACCGCTGCTGTACCGCGTTCTGGGGGCGTGGAACGTCCAGCAGATGCTCGGCCACTTCTGCCTGATCGTGGCCGTCAGTGCGAACGTGTATCACATGCTGGTGCGACTCGCCGATCCCGATCAGGTGCGCTCGATCATGCGCCGCCACCTGATGCCGCCGGTACTGCTCGGCATCGGGTTGATGGCGCCTTCATACCTACTGGCCGACCAGGAGTACCACCCGGACATGTTCGCCGCCGCAAGCCGTGATCCCTGGCTGACCGTCTACAAACTGGTGGGCTGCGCCCTGGTGATCTACCTCAGTGGCTACGTCAGCCGGCTGATGCTGTTGCTGCGGAAGGATCCGCGGGCCAAGTCCACCATCGACCTCTACCTGGTGTCGATGACCTTCGCCACCGCGGCCTGTCTGATCGTGGTCGGTGCGGCATGGGGCGGCCGTGCCGATGCCGGTCCGGCGATCTGGGCCTGCATCTGCTTGTCGGTGGGAACCTTCGCGTTCGGGTCGGCGCGGTCGTGGCAGGCCAAAAGCGCATGGTTCACCTCGGGGGGCGGCACAGCGATCGGCGCGCAATGACGTCGGTGTTCATCGCCGCCACACTGGCGGTGATCCTGTACAGCCTGTGGGTTCGACGCGACACCTGGTGGTCTCGGTGGGAGGCCGCCGCCACCTTCGCCATCGCGACGGAGGGGTGCGCACTGGTGTTGCTGTCGCCGTGGGCCGGCACCGAACTAGGGCCGCGGCTGTACCACTGGCTGGGGTTGTGGAACGTCCAGCACCTGCTCGGCAGCCTTGTCCTGATCGTGGCGGTGATCGCGAACATTTACCACATGATGGTGCGACTCGCCGATCCCGACCAGGTGCGACCGCTCATGCGTAAACACCTGCAGCTGCCGCTGGGGCTGGGTGTCGCGGTGCTGCTGGTCACCTTCGTCAAGCTCGAGCGGGGCCACGAGCCCGACATGTTCGCCAACCTGACCGGCAACGGCTGGTGGCTGACCGCCTACGAGGTGGCCGCGTGCTGGATCGTGCTCTACTTGAGCGGCTACGTTGGTCGGCTGATGCTGGCGCTACGGCACGATCCCCGCGCGAGGACCACGGTCAACCTGTACCTGGCATCGATGTCGTTCACGGTGCTGGCATGCCTGGTCGCGATCGTCTCGATCTGGGCCGGCGGCTATGCCGGGCCGGCGATCTGGGGCTGCATCTGCCTGTCGGTGATGATCTTCGCCTACGGGCTGGCACGATCCTGGCGGGCCAAGACCGCCTGGTTCTCGCCGGGCGCCTCCGCAGCGGGGTGATCGGGTGGTGCTCGCTTGGTTGAGTCTGCGCTCAGGGCGGCGGCTACCCGCACTTTCTCGCCGTAGCCGCAGTGCCAACGGTAGAAAATGAGTGCGCCCGAAGGGATTCGAACCCCCAACCTTCTGATCCGTAGTCAGATGCTCTATCCGTTGAGCTACGGGCGCCTGTCTTCAATTGTCGGTCGAGCAAGCCCGGCCGTGGCGGAGGCGAGAGGATTTGAACCTCCGGTCCCCCGTTAAGGGGACAACTCATTAGCAGTGAGTCCCATTCGGCCGCTCTGGCACGCCTCCTCGAACTTGTCGAGGGTACCGGATCGATGCCCGAGCTTCGAAACCGCGGTTCATACCGCCCACATATGCTGTGGTCCGTGACCGTCCGCCTGCGCCCCGAGATCGCCGCACTGCCGGCATACGTCGAGGGCAAGACGGTACCGGGATCGATCAAGCTGGCCAGCAACGAGACGGTGCTGGAGCCGCTGCCCAGCGTGGTCAAGGCCGTCGAGGCCGCGCTGGCCGGCATCAACCGCTACCCGGACAACGGCTACGCGACGCTGCGGGCCCGGCTGGCCAGCCATGTCGGGTTCGCCCCCGAGCAGGTGGCGGCCGGCTGCGGGTCGGTGAGCCTGTGCCAGCAACTCATCCAGATCAGCTGCGGCGCCGGTGACGAGGTGATGTTCGGCTGGCGCAGCTTCGAGATCTACCCGCTGCAGGTGCGCACCGCCGGTGCCGTGCCGGTGCAGGTGCCGCTGCGTGATCACGCCTACGACCTGGACGCGATGCTGGCCGCCGTCACCGAGCACACCCGGCTGATCTTCATCTGCAACCCGAACAACCCCACCTCCACCGTGGTCGACCCCGACGCGCTGGCGCGGTTCGTGGCCGCGGTGCCGCCGCACGTCCTGGTCGCCATCGACGAGGCGTACGTGGAGTACATCCGCGAGCCCATGACCCCCGACAGTCTGGGGTTGGCGCGCCGCTACCCGAATGTGGTTGTGCTGCGAACCTTTTCCAAGGCCTACGGGCTGGCGGGCCTGCGGCTGGGCTACGCGGTCGGCGATCCGGAGATCATCACCGCACTGGGCAAGGTCTATGTGCCGTTCACCGTGTCCAGCGTGGCGCAGGTCGCCGGGATCGCGTCGATGGACGCCGGTGACGAACTGCTGGCCCGTACCGACGCGGTGGTCGCCGAGCGGGCCCGGGTCGCCGCGGCGCTGCGTGACGCCGGGTTCGAGCTGCCGGATTCGCAGGCCAACTTCGTGTGGCTGCCGCTGGCGGCGCGCACCGCGGACTTCGTGGCCGCCGCCGCGGACGCCCGCATCGTGGTACGCCCCTACGGGCAGGACGGGGTCCGGGTGACCATCGGCGCGCCGGAGGAGAACGACGCGCTGTTACGGTTCGCTCAGGACTGGATCTGACGAGGAGTTCTATGCACGCCACCGCAACCGCCACCGTCGCCGCGCCCGCATCCCGGGTGTGGGAGGTGCTCTCCGACTACGAGGGCATGTCCTCCTGGGCTCCCGGTCTGAAGATCACCGTGGTCCGGCCCGGGGCCCCCGAGCCCAACGGAGTCGGCGCCCAGCGGCGCATCCAGGCGGTGCCCGGGATGGCGCCCCTGGTGGAGGAGATCACCGTGTTCGATCCCGACCACCGGCTGAGCTACCGGGGTGTGTCGGGCATCCCGTTCCGCAACTACGTCGGCGACGTGGTGCTGGCGCCGGCGGGTTCGGGCACCCAGGTCAGCTACACCGTCAGCGCCGATAACCGGCTGCCCGGGGTGGCCTCGGTGTTGGCCAACGTTTTGCTGTTCGGTCTCAAGCGGGCCGTGAAAAAGGCCGGATGAGGAGTTAGACGATGAATGACGACCTGGCCCGGAAGACGTTCACCGCGTTCAAGGAGCGCACCGACACCATCGCGGATGCCGAGCTGGATGAGTTCTGGGCGGCACTGCCCCCGGCCACCCTCGATCAGCTGATCGGCGAGTGGCGCGGCGGCGAGTTCGTCACCGGCCACAAGATGAACGGGTTGCTGGAGAAGGCCCGCTGGTTCGGCAAGACGTTCAACTCGATCACCGACGTGCAGCCGCTGGTCTGCCTGGATGAGGACGGCAACAAGTTCTCCAACACCAAGCTCGGCAAGGGCGAGGCAAGCCTGTGGGCCGAGGAGTTCCGCGGCGAGGTGGTGGCCACCATGGTCTATGACGGCCAGCCCACCCACGACCACTTCAAGCGCGTCGACGACGACACCGTGTTCGGCATCATGAACGGCAAGGGCGTGCTCGATGACGGCCGCTACTTCTACTTCTACCTCGAGCGGGTCTAAGGCCACGATTGGTCGCCCCGGCGGGCGGGAACCCTCCGAGGCATGTCTACCTACCGAGTACTGAACCCGCACGGCGAGATCGTGGGCACCAAGGACATCGCCAGCGCCGACGACGCGCACGCCTGGTTCGTCGACGTCAAGGCCGACAACACCGAACTGGGGTGGCGGATGGAGGTCGACCTCGACGGCCAGTGGCGGTTCTTCGACAGCACCGAAGGCGACCGCCCGTAAGCACCGCCTGCGCCGAGCAGGCCGTCAGCGGTGTAGCGCCAGTTCGCGATCGTCTTTCGCCGCGGTCTGGGGTTCGCCGCGGCGGCTGAGCAAAGACGCCACGACGGTGAGCGCGAGCACGCCGACAATCACCAGCAGCGACACCCCGGTACCGATCTCGGCGACGCCGACGCCATCTTGGTGCAGGGCGTGCAGTATCAGCTTCACGCCGATGAACCCGAGGATCGCCGAGAGTCCGTAGGACAGGTAGACGAGCCGATCGAGCAGGCCGTCGATGAGGAAATAAAGCTGCCGCAGGCCCAGCAGGGAAAACGCCGTCGCGGTGAACACGATGTAGGTGTTCTGCGTGAGTCCGAAGATCGCCGGGATCGAGTCCACGGCGAAGAGCACGTCGGTACCGGCGATGGCGATCACCACCAACAGCATCGGGGTCATCGCCCGCCGGCCGCCCACCGTCGTGACCAGCTTGTCGCCGTCGTAGTGCTCGCTGGTGTGAATCATTTTCTTCGCCAGCCGGATGACACCGTCATGGGCACGGTGGGGCTCGCCGCCGCGGGCCGTCCTGAACATATTGCGGGCCGTCAGCAACAGCGCGAAGCCAAAGAAGTAGAAGACCCAGGCGAAGGTGTCGATCAGCGCGGCGCCGAGAAAGATGAAGCCGGTCCGGGCGGCCAGCGCGAAGGCGATCCCGAACAGCAGCACCTTCTGCTGGTACTCGCGGGGCACCCGGAAGCTCGTCATGATGATCAAGAAGACGAACAGGTTGTCGACCGACAGCGCCTTCTCGGTCACGTAGCCGGCGAAGTACTCCGAACCCGCGTCCGCTCCGCCGAAGATCAGCATGCCGAACCCGAACAGCACCGCCACGCCGACGTAGCCGGCGGACCAGCCGGCGGCTTCTCTGAGCGTCGGGATATGGGCCCGGCGGACGTGGAACACGTAGTCGAACGTGAGCAATCCGGCGAGGCCGACGATCGTCAGCCCCCATACCCAACCGGGAATGTCCAT

Protein sequences of DBSCAN-SWA_2

>NC_015576|4290854:4300487|4298780_4299248_+|WP_013830973.1|DBSCAN-SWA
MNDDLARKTFTAFKERTDTIADAELDEFWAALPPATLDQLIGEWRGGEFVTGHKMNGLLEKARWFGKTFNSITDVQPLVCLDEDGNKFSNTKLGKGEASLWAEEFRGEVVATMVYDGQPTHDHFKRVDDDTVFGIMNGKGVLDDGRYFYFYLERV
>NC_015576|4290854:4300487|4291674_4292019_+|WP_013830964.1|DBSCAN-SWA
MARTPQEIFDHHLHALIARDVDDLLVDYTDDSVLITAAGVATGLDGIRAAFSQLSDALAAAVFDIKSKTYHDEILLLEWTLDSPGFQVDGVDTFVFGEDSIRVQTISQLVRPKG
>NC_015576|4290854:4300487|4299290_4299479_+|WP_041319087.1|DBSCAN-SWA
MSTYRVLNPHGEIVGTKDIASADDAHAWFVDVKADNTELGWRMEVDLDGQWRFFDSTEGDRP
>NC_015576|4290854:4300487|4294364_4294673_+|WP_013830967.1|DBSCAN-SWA
MDDRHKDPTVVLPYLVGRPLGATEVYEAFGYRKSAYYKAAHEGRLISADNLIRVARYFGLNPVDLQVRFGLIEHDAVTEYLESSSRPLRLGDLKADLDKPPV
>NC_015576|4290854:4300487|4294701_4295457_+|WP_013830968.1|DBSCAN-SWA
MTSAFIGATVLVALYSLWVRRETWWSRWEIGITLAIALEVCALVLMSPWASAVLGPTMHSVTRIWNVQQLVGHICFIVAIAANIYHVLPRLADFGRVRPLFRRHVQWPVRLGLVALVAVFITADADYRPDGLSTGNDTGAWAEIYWLLFCGMLIYLSGYATRLLLLVRSDPRARETVELYTASAAFALAGLVAQLSTTWTNADASQLVWPCACISVVIFAYGSARSWQAKAAWFAARTRPVKEPNPPPALS
>NC_015576|4290854:4300487|4292026_4293052_+|WP_041319083.1|DBSCAN-SWA
MDLEPVAQWMSDRQLGEGPLSDVTELSGGTQNVMLRFTRSGRSYVLRRGPLHLRPRSNDVMLRETRVLAALADTDVPHPGLIAVCDDPAVLGDAVFYLMEPIDGFNASGELPELHANDPAVRYEMGLSMADALAKLGAVDHVAVGLADYGKPDGFLERQVPRWLSELDSYRQFENYPGPELPGLDEVAGWLQRNVPASWQPGILHGDYHAANVLFSPTGPQVAAIVDWEMSTIGDPLLDLGWLLATWRQDDGSSVFSHTLTGMDGLASTDDLVQRYANGSSRDLSHIGWYEVMASFKLAIVIEGTLARASAGMAQQDVGDQLHEAAVWLFERAQTLIASKT
>NC_015576|4290854:4300487|4290854_4291559_-|WP_041319080.1|DBSCAN-SWA
MARADGKPITVLVVDDETVLAEMVSMALRYEGWTTATAGDGASAIAAAKAERPDVVVLDVMLPDMSGLDVLRKLREINPRLPVLFLTAKDALEDRIAGLTAGGDDYVTKPFSIEEVVLRLRALLRRTGVSTAEAGAQIVVGDLVLDEDSHEVTRGGDPITLTSTEFELLRYLMHNARRVLSKAQILDRVWDYDFGGRANIVELYISYLRKKIDNGREPMIHTLRGAGYVLKPAV
>NC_015576|4290854:4300487|4299503_4300487_-|WP_013830975.1|DBSCAN-SWA
MDIPGWVWGLTIVGLAGLLTFDYVFHVRRAHIPTLREAAGWSAGYVGVAVLFGFGMLIFGGADAGSEYFAGYVTEKALSVDNLFVFLIIMTSFRVPREYQQKVLLFGIAFALAARTGFIFLGAALIDTFAWVFYFFGFALLLTARNMFRTARGGEPHRAHDGVIRLAKKMIHTSEHYDGDKLVTTVGGRRAMTPMLLVVIAIAGTDVLFAVDSIPAIFGLTQNTYIVFTATAFSLLGLRQLYFLIDGLLDRLVYLSYGLSAILGFIGVKLILHALHQDGVGVAEIGTGVSLLVIVGVLALTVVASLLSRRGEPQTAAKDDRELALHR
>NC_015576|4290854:4300487|4298355_4298769_+|WP_013830972.1|DBSCAN-SWA
MHATATATVAAPASRVWEVLSDYEGMSSWAPGLKITVVRPGAPEPNGVGAQRRIQAVPGMAPLVEEITVFDPDHRLSYRGVSGIPFRNYVGDVVLAPAGSGTQVSYTVSADNRLPGVASVLANVLLFGLKRAVKKAG
>NC_015576|4290854:4300487|4295466_4296204_+|WP_049792958.1|DBSCAN-SWA
MTSGFIAATLALIAYSSWIRRDTWWSRWEVAASLALVLEGAALLLMSPWGAPVFGPLLYRVLGAWNVQQMLGHFCLIVAVSANVYHMLVRLADPDQVRSIMRRHLMPPVLLGIGLMAPSYLLADQEYHPDMFAAASRDPWLTVYKLVGCALVIYLSGYVSRLMLLLRKDPRAKSTIDLYLVSMTFATAACLIVVGAAWGGRADAGPAIWACICLSVGTFAFGSARSWQAKSAWFTSGGGTAIGAQ
>NC_015576|4290854:4300487|4297297_4298344_+|WP_013830971.1|DBSCAN-SWA
MTVRLRPEIAALPAYVEGKTVPGSIKLASNETVLEPLPSVVKAVEAALAGINRYPDNGYATLRARLASHVGFAPEQVAAGCGSVSLCQQLIQISCGAGDEVMFGWRSFEIYPLQVRTAGAVPVQVPLRDHAYDLDAMLAAVTEHTRLIFICNPNNPTSTVVDPDALARFVAAVPPHVLVAIDEAYVEYIREPMTPDSLGLARRYPNVVVLRTFSKAYGLAGLRLGYAVGDPEIITALGKVYVPFTVSSVAQVAGIASMDAGDELLARTDAVVAERARVAAALRDAGFELPDSQANFVWLPLAARTADFVAAAADARIVVRPYGQDGVRVTIGAPEENDALLRFAQDWI
>NC_015576|4290854:4300487|4293048_4294287_+|WP_013830966.1|DBSCAN-SWA
MTGHLDEIDRIVAADTFRLVDIFKDLHRNPELGFEEVRTARIVAQALGNLGFTVTTGIGRTGVVAVLANGPGPVVMYRADMDALRVPEATGLDYASSDPSLGHMCGHDAHVTWMLGMAKVLAETTASWSGTAVLIGQPAEELIAGARAMVDDGLYDVAPPPDSFIAMHTVPVPVGMVAAAGGERMAGTDQLEIVFHGVGGHGSLPQLAKDPVLMAAQAVVQFQGIISRSIAPSEGAVLTVGSVQAGTTYNVIPDQARLLANLRWYNPEVREQLLAGIRAISEGIAHSFGLPDALMPVITMGGGSTPLVNDADLTGRLAATLRDALGEHNVITELPEVSASEDCHLLKGPHRDVPLAYLMVGVADPQVYAEAAARGQLFPYTPHSPDYVVDLAAIPLGARIASRAMLELLATS
>NC_015576|4290854:4300487|4296200_4296929_+|WP_013830970.1|DBSCAN-SWA
MTSVFIAATLAVILYSLWVRRDTWWSRWEAAATFAIATEGCALVLLSPWAGTELGPRLYHWLGLWNVQHLLGSLVLIVAVIANIYHMMVRLADPDQVRPLMRKHLQLPLGLGVAVLLVTFVKLERGHEPDMFANLTGNGWWLTAYEVAACWIVLYLSGYVGRLMLALRHDPRARTTVNLYLASMSFTVLACLVAIVSIWAGGYAGPAIWGCICLSVMIFAYGLARSWRAKTAWFSPGASAAG

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_041319080.1|4290854_4291559_-	response regulator transcription factor	W8CYM9	Bacillus_phage	2.4e-35	37.8
WP_013830964.1|4291674_4292019_+	nuclear transport factor 2 family protein	NA	NA	NA	NA
WP_041319083.1|4292026_4293052_+	phosphotransferase family protein	NA	NA	NA	NA
WP_013830966.1|4293048_4294287_+	amidohydrolase	NA	NA	NA	NA
WP_013830967.1|4294364_4294673_+	hypothetical protein	A0A222ZM11	Mycobacterium_phage	2.1e-15	43.6
WP_013830968.1|4294701_4295457_+	hypothetical protein	A0A2P0ZZX9	Mycobacterium_phage	4.6e-32	36.4
WP_049792958.1|4295466_4296204_+	hypothetical protein	S5Z9J2	Mycobacterium_phage	5.5e-30	35.9
WP_013830970.1|4296200_4296929_+	hypothetical protein	A0A2D2W392	Mycobacterium_phage	8.1e-26	33.8
WP_013830971.1|4297297_4298344_+	histidinol-phosphate transaminase	A0A1X6WGT4	Pacmanvirus	2.4e-15	25.1
WP_013830972.1|4298355_4298769_+	SRPBCC family protein	NA	NA	NA	NA
WP_013830973.1|4298780_4299248_+	DUF4334 domain-containing protein	NA	NA	NA	NA
WP_041319087.1|4299290_4299479_+	hypothetical protein	NA	NA	NA	NA
WP_013830975.1|4299503_4300487_-	TerC family protein	I7HPH5	Enterobacteria_phage	2.8e-37	35.9