CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_015578	Treponema primitia ZAS-2, complete sequence	13 crisprs	DEDDh,PD-DExK,cas3,csa3,DinG,WYL,csx1,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	0	2	6	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_015578_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015578_1

234325-234435

Orphan

Consensus_repeat	Method
GGGCAGCGGCGGCGGAATTCTGGTGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015578_1

>merge|NC_015578|1|234325-234435|CRISPRCasFinder
GGGCAGCGGCGGCGGAATTCTGGTGGGCGGCTATAACGCTTCGGTCACCATGAACGGCGGCGCGGTGAGCAATAATACGGCGATGGGCAGCGGCGGCGGAATCCTGGTGGG

>NC_015578|1|1|234325-234435|CRISPRCasFinder
GGGCAGCGGCGGCGGAATTCTGGTGGG	CGGCTATAACGCTTCGGTCACCATGAACGGCGGCGCGGTGAGCAATAATACGGCGAT
GGGCAGCGGCGGCGGAATCCTGGTGGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_015578.1\|WP_041610961.1\|222832_223498_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015706404.1\|223547_225371_-\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|214599
NC_015578.1\|WP_015706411.1\|234968_238925_+\|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme	unknown	unknown	gnl\|CDD\|335469
NC_015578.1\|WP_015706406.1\|226518_226872_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NC_015578.1\|WP_015706417.1\|245957_247148_+\|DNA-polymerase-IV	unknown	unknown	gnl\|CDD\|176459
NC_015578.1\|WP_015706407.1\|226880_228842_-\|ATP-dependent-zinc-metalloprotease-FtsH	unknown	unknown	gnl\|CDD\|273520
NC_015578.1\|WP_041611340.1\|250816_251935_+\|S-methyl-5-thioribose-1-phosphate-isomerase	unknown	unknown	gnl\|CDD\|235578
NC_015578.1\|WP_174269880.1\|243465_244494_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237865
NC_015578.1\|WP_015706416.1\|244554_245904_+\|galactokinase	unknown	unknown	gnl\|CDD\|223231
NC_015578.1\|WP_015706412.1\|238937_239774_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015706414.1\|241758_243375_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015706403.1\|221644_222757_+\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|379234
NC_015578.1\|WP_041611338.1\|239854_241756_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|276809
NC_015578.1\|WP_041610960.1\|220758_221574_-\|phosphohydrolase	unknown	unknown	gnl\|CDD\|225831
NC_015578.1\|WP_041611337.1\|225620_226424_+\|M15-family-metallopeptidase	unknown	unknown	gnl\|CDD\|379247
NC_015578.1\|WP_015706418.1\|247265_248966_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_052299682.1\|218540_220751_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224225
NC_015578.1\|WP_015706419.1\|248978_250403_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_041611335.1\|217864_218503_-\|CatB-related-O-acetyltransferase	unknown	unknown	gnl\|CDD\|100040
NC_015578.1\|WP_015706409.1\|229041_231918_+\|bacterial-Ig-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|369401

Protein	Function_ID	Function_description	E-value
NC_015578.1\|WP_015706404.1\|223547_225371_-\|HAMP-domain-containing-protein	gnl\|CDD\|214599	smart00283, MA, Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.	1.36853e-44
NC_015578.1\|WP_015706411.1\|234968_238925_+\|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme	gnl\|CDD\|335469	pfam03781, FGE-sulfatase, Sulfatase-modifying factor enzyme 1. This domain is found in eukaryotic proteins required for post-translational sulfatase modification (SUMF1). These proteins are associated with the rare disorder multiple sulfatase deficiency (MSD). The protein product of the SUMF1 gene is FGE, formylglycine (FGly),-generating enzyme, which is a sulfatase. Sulfatases are enzymes essential for degradation and remodelling of sulfate esters, and formylglycine (FGly), the key catalytic in the active site, is unique to sulfatases. FGE is localized to the endoplasmic reticulum (ER) and interacts with and modifies the unfolded form of newly synthesized sulfatases. FGE is a single-domain monomer with a surprising paucity of secondary structure that adopts a unique fold which is stabilized by two Ca2+ ions. The effect of all mutations found in MSD patients is explained by the FGE structure, providing a molecular basis for MSD. A redox-active disulfide bond is present in the active site of FGE. An oxidized cysteine residue, possibly cysteine sulfenic acid, has been detected that may allow formulation of a structure-based mechanism for FGly formation from cysteine residues in all sulfatases. In Mycobacteria and Treponema denticola this enzyme functions as an iron(II)-dependent oxidoreductase.	5.50806e-31
NC_015578.1\|WP_015706406.1\|226518_226872_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	1.2674e-08
NC_015578.1\|WP_015706417.1\|245957_247148_+\|DNA-polymerase-IV	gnl\|CDD\|176459	cd03586, PolY_Pol_IV_kappa, DNA Polymerase IV/Kappa. Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.	3.60034e-147
NC_015578.1\|WP_015706407.1\|226880_228842_-\|ATP-dependent-zinc-metalloprotease-FtsH	gnl\|CDD\|273520	TIGR01241, ATP-dependent_zinc_metalloprotease_FtsH, ATP-dependent metalloprotease FtsH. HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides].	0
NC_015578.1\|WP_041611340.1\|250816_251935_+\|S-methyl-5-thioribose-1-phosphate-isomerase	gnl\|CDD\|235578	PRK05720, mtnA, methylthioribose-1-phosphate isomerase; Reviewed.	2.04238e-165
NC_015578.1\|WP_174269880.1\|243465_244494_+\|hypothetical-protein	gnl\|CDD\|237865	PRK14951, PRK14951, DNA polymerase III subunits gamma and tau; Provisional.	5.22315e-05
NC_015578.1\|WP_015706416.1\|244554_245904_+\|galactokinase	gnl\|CDD\|223231	COG0153, GalK, Galactokinase [Carbohydrate transport and metabolism].	8.45312e-38
NC_015578.1\|WP_015706403.1\|221644_222757_+\|VWA-domain-containing-protein	gnl\|CDD\|379234	pfam13519, VWA_2, von Willebrand factor type A domain.	4.84153e-09
NC_015578.1\|WP_041611338.1\|239854_241756_+\|hypothetical-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	2.48812e-07
NC_015578.1\|WP_041610960.1\|220758_221574_-\|phosphohydrolase	gnl\|CDD\|225831	COG3294, COG3294, HD supefamily hydrolase [General function prediction only].	3.21199e-68
NC_015578.1\|WP_041611337.1\|225620_226424_+\|M15-family-metallopeptidase	gnl\|CDD\|379247	pfam13539, Peptidase_M15_4, D-alanyl-D-alanine carboxypeptidase. This family resembles VanY, pfam02557, which is part of the peptidase M15 family.	2.77727e-15
NC_015578.1\|WP_052299682.1\|218540_220751_-\|hypothetical-protein	gnl\|CDD\|224225	COG1306, COG1306, Uncharacterized conserved protein [Function unknown].	4.29302e-100
NC_015578.1\|WP_041611335.1\|217864_218503_-\|CatB-related-O-acetyltransferase	gnl\|CDD\|100040	cd03349, LbH_XAT, Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and streptogramin, among others. Members of this class of enzymes include Enterococcus faecium streptogramin A acetyltransferase and Pseudomonas aeruginosa chloramphenicol acetyltransferase. They contain repeated copies of a six-residue hexapeptide repeat sequence motif (X-[STAV]-X-[LIV]-[GAED]-X) and adopt a left-handed parallel beta helix (LbH) structure. The active enzyme is a trimer with CoA and substrate binding sites at the interface of two separate LbH subunits. XATs are implicated in inactivating xenobiotics leading to xenobiotic resistance in patients.	2.36122e-70
NC_015578.1\|WP_015706409.1\|229041_231918_+\|bacterial-Ig-like-domain-containing-protein	gnl\|CDD\|369401	pfam07523, Big_3, Bacterial Ig-like domain (group 3). This family consists of bacterial domains with an Ig-like fold. Members of this family are found in a variety of bacterial surface proteins.	3.77787e-06

>NC_015578.1|WP_015706409.1|229041_231918_+|bacterial-Ig-like-domain-containing-protein
MAFLVASCDLFMNKPERNIRDDIKTTVEIANAPIISVTVEAVPAAAGRTNPEGAHTEKQRVPFTVSFIISDEYSFITWQAWQQVNGVETLLSGDQVQFSATGNENFETQVTIINTGSAISVRPLVIARPRMVFNNLPGGEYPRTVTNYPVRIWFAEPLSRESLLDPANSINYKNISVTGKGRFGADPEIDLKGYFNLGLNDDGTLLTLKVNTDKGYIGLPGNTNVTITLETGILTGGEHGVSLLNPVVLHYGVGDKPDRDPPVVEILRGFFQSGGSDKMIDDGDSFRFVYDGSYTFSVEAPTRLAPLDANGKATAIYLVFKAYDELGEIQGVTVSENRIYDLEGGNPVYETDTENVTVYQDYDQFHESLPLDQMATYQSLLSPGESPPLVVRHVIKSAEDGILDLIILPEDSVGNRADPMAAYEPFQAPQRIRVALDFPPDPVKSLTGEYKEPNLEISWANPQAKDLAEIRLSYRNNSAGTPEETIVLPPVSVDYPIGVVKGNNYTIRLTAVDHGDKESSPEEITMTASAPPVATYRIRATASAGGRVSANPIRSAEGGLVTLTATPDRGYRFRGGSLSAKLAEDGASIPLSGNTFTMPAGDVEVSAGFEADEYAITGFNANGGTISAVPAGTRITAGKTVTLTVTPDPGNVLKTLAVKRTDTNGAVMVSGYNNVYTFTMPAGNVELSALFEPLPSNAYLINMAPWINGGFISSPLNYGIAGSLITLTVKPVSGFQIKPNARPTVTRTDTNVKLPVYGATGATAYTFTMPAAAVELSAEFEGLPITIQSPPNKTAFNLGHTLTEADLEGLVVAAVNTNGSSQPLPIALNNISGFNSNVSGVQTLTVTVNGKTASFTVTIRDQGNISIDLDDPNLGLPKDIVISKTSAAPNPKTVTVSVYGTYTAYNWYVNNTEISDSKDRPILILDASKYPLGRNYLRVEVRKGNVYYSREIDFKVEG
>NC_015578.1|WP_015706407.1|226880_228842_-|ATP-dependent-zinc-metalloprotease-FtsH
MSDYQNDGSGNDKKKPKNSGPQFPFGGPKLPDPKKFGGWRFSIVYILILVVGMSLFNYVFLNKVNPTIDFSEFKNKIVSGEIKRVEMTDSYFTGYTAAQKTVAPTPGLRNPYGSSPDAIFRTVPLNDPDIIKLMDEKGVSYYAVSREGSTVLNLIFSWVLPIAFFFFIWRFLMKRLGNMGGNVLSVGQNRAVIVAEGDIVTRFPDVAGVDEAKDELVEVVDFLKNPKKYTDIGGKIPKGVLLVGPPGTGKTLLARAVAGEAGVSFFRMSGADFVEMFVGVGAARVRDLFKQAREKAPCIVFIDELDAIGKSRLNNIAGGNDEREQTLNQLLVEMDGFDATSGLIILAATNRPDVLDPALLRPGRFDRQVLVDRPDLKGREAILRIHAKAVKLDPQVDLAAVARGTPGFVGADLANIVNEAALLAVRGGRQVVSQKDFEEAIEKTVAGLEQKNRIISDDERRIVAFHETGHALVAAFTPGSDPVQKISIVPRGFGALGYTLQMPVEDRYLMTEDELLGKIDVLLGGRAAEELVFSRISTGAANDLTKATDIARKMITDYGMSARFKNVALTQRGAGMMGGAAQEPMFHREYSEATQQYIDEEIARMVETRYAGVKDTLKQRRDLLDLVGAQLLEKETLDEKEFKGLIGQPVAAV
>NC_015578.1|WP_015706406.1|226518_226872_+|helix-turn-helix-transcriptional-regulator
MLSNNEETKIRGLLSKNIKRLRAKNSLSQMNLAIQAGLTHNFINDIESGKKWLSPKTLAKLSMALQAEPHEFFAPEITIPEADSGTLSEYLDDVTETFQRMVEDIKERYFQDTDSKD
>NC_015578.1|WP_041611337.1|225620_226424_+|M15-family-metallopeptidase
MKALAAAYPGRVGAAVFRKGTPADTGDWAVQIRETWFYYAQGRLLPEELRNRYAEYDPQPFYNYPAELPAWKDPSPEETERFRNSAQMRQANPPKRSQFFFDALWRSSTREEAYERVKTMRFLGKSVTVHYSIMEELALVEERILWEANNSTLVRQWVNRLDTLAGWNWRSIADTQSRSFHAYGAAVDLLPASQGGLQSYWLWTSQNYPAWWAVPYEKRLHPPAAVIRAFEEYGFIWGGKWLFFDTMHFEYRPEILLLNNMPVKAAY
>NC_015578.1|WP_015706404.1|223547_225371_-|HAMP-domain-containing-protein
MKKVVSLKTQFMVFFTAFILVLSTAITVLALRESLEVATTIFIREGIAVINKAVDMVDGDAFERLSASLDENDPFYEDTRLELLFLKENSVTLYLYTMAPVQGSVYKYIIDGSAPPDDEENFSPLGAEEDTSSYDKAFQRTWKTGTQQSGGMVKQGGWGWLVSVYSPIKNSRGQMVGIVGCDFEAQSLFDMIQTQTIRQVALGVILSLIGIVITWFFLRALFSRLGTVSSILKSVSEGEGDLTKRITIKRMDEIGTLASFFNQTLDKIRNMVVTIKEQTVSLSDIGSELSSNMTETAAAINQITSNIQSIKGQALNQSASVSETSSVMEKVTVNIEKLNSQVEKQTSSVSQSSSAIEEMLANIQSVTQTLVRNAENVEELIAASEVGRTGLQGVSADIQEIARESEGLLEINSVMQNIASQTNLLSMNAAIEAAHAGEAGRGFAVVADEIRKLAENSGQQSKIISDTLKKIKESIDKITKSTNTVLNRFEAIDTGVKTVSDQETHIRNAMEEQGQGSQQILEAIAKLNDITQQVKQGSLEMLEGSKEVINESKNLELVTQEITNGMNEMATGAEQINSAVNRVNTISGDNQEHINTLATEVARFKVE
>NC_015578.1|WP_041610961.1|222832_223498_+|hypothetical-protein
MRVFKVALMAGIFFAFFLLPLLPAEEPDTGTLLDTIQELATPIPETLKNEAEAEEYEDFDDFDEETILDFEGPEITIFYNERNEADYIEVKTDEKIEEYHYLSHIKYSDLIFVLSDLLRRITREGYQWARAPAISYEKSDEIVLLYRKDLVNDMVYGIVQFPDFKVWLSAIRQQDREHRYNAGSGRDMLMLVYAFAQCLAQAEQTLGISQVEYTMRFFKPE
>NC_015578.1|WP_015706403.1|221644_222757_+|VWA-domain-containing-protein
MRRTCSILAGIFFFLAPLFIFSQDLSIQTEDLRIEQRVDGGFHLFIRKKPGINSVLLTESTRDPSLNEDNYAYRAAEWNPINGDEIRLLDGVPIARESGIWSLIDSTPEPDSQFGQAFRIYIPWILYYGYSDTRHGEIYVVDGTYLNIRAFTLPYGDYQGSFRDNPFAVLVTQQPLAGPPEGNYMKDTVDSFTEIVAGKGDLIYSTGADDLVTKIGEILEEEKGKKVDIVLCLDTTGSMRDDIDSVRRLLIPLLEGMIADFNGFRIGMVLYKDYYETYLTRVVGFTADFSKFRTTLNNIQVGGGRDIPEAVHEALYEGATKFPWNAESRLLLLIGDAPPHPRQRGKISKEMVDKAVEDKGLKLSAIILPQ
>NC_015578.1|WP_041610960.1|220758_221574_-|phosphohydrolase
MRSQKGNVLDGKIIEMITGFGLSGKAVEAAKLVLEDAEVQAMQEYANTVSIMRLNYNDHGPVHMRTVALNALIMMGLLRDAGIKTNLEKEDCGTFEDSLIAVLLASVLHDLGMTIGRQDHELHSVYLAYPILDRLLRKVYAADLQKLVTVRSLALEGISGHMGTRTIHSLEAGLIQIADGCDMTKGRARIPLIVAGGPRPGDIHQLSANSIEDVRISRGTEQPIRIDIRMSGEIGLFQIEEVLLGKIAKSTAKIYTELYALMDKGELKRYL
>NC_015578.1|WP_052299682.1|218540_220751_-|hypothetical-protein
MVLKSPRPFNSMAVTFLLSCSLLILLSPGAGTQTSLPAQNTWPTVIGTDKGLYGMDRLGIVRPLWTGGAVRKILKTANYWAILGDQGILVSTDLLRWETRNRGLPVKTIKNYDDGQKTFTYMVQELKDLEALPEDPETLVCATKDTVFLSRDAGKTWESLGAPPYRTNGIKAVAATLLPAPGSAQPALTVFLSHSTYGIYYRALDSRNAGWVEMNQGLERLETTTNPDEVSDIAVAVPTGSAGNGSPRIYVSQTFRRRIYQLNWEQKRFTPIWSDSADFGTVDSLDIGAQGIRFVQEGAVMELNYPPAVISAVSSTSLVTRDRPDLNSFIRQIPSAWGIKPSSLISWGSAARIDEDPVTLSELWLLDTGTGKEAARGKQGLYLPVNHAMESRTLAPYLKVIEESALDMVVIDMKDDYGRLRFSPNNPAIPEKGRVFRPVDIDAFLKTMQDRGIYTVARIVVFKDPELARKEGGKFAVWDSHNRKPWVGYYDQRQPKGTGADKDSSYETAILSADDPTYEILRTYYDERWVDPYSEEVWEYTAAIAGELIDRGFDEIQFDYIRFPTDGANLGDAQYRWRENGMDMDSAILSFLRHIRSRITAPISIDIYGANGWYRTGARTGQEVELLAPYVDVICPMYYPSHFEQDFLAQSPAEQRPYRIYFQGSQRTERIGRGQIIVRPYVQAFFLNVSYDRQYYNPDYVRRQVEGVRDAGANGLTYWNNSGRYDDIPLRGAPGL
>NC_015578.1|WP_041611335.1|217864_218503_-|CatB-related-O-acetyltransferase
MENNELPDPDMIFPIPNLNMLINIKPTIKNKNIIVGDFTYFSGDDFEKQVTHHYEWLNDKLIIGKFCQIAAGVEFIMNGANHQMNCVSTFPFNIFKKWNEIVSPDEIQTKGDTIIGNDVWIGQNSTILPGIKIGDGAIIGTRSVVGRDVEPYTIMAGNPAKIIRKRFGNELIEIMLKLKWWDLPVSEIRKLIPILHNKDIEYVKEELKKALK
>NC_015578.1|WP_015706411.1|234968_238925_+|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme
MATKKRVPIITVLFAALLAAMLISCQNSLLEAPDSPENPGTVIIQIGYPAVRTAVPDISSAAGLGLNYKIVIADATGSGKIYGKAEGPGNTITVILDELPAAGNYAQVSAEGYQGETLMFRGISESLPGANLKSRPVSITLTPVMEGTGSVNLTVQFPGSAAYSVARVEAALYLPGIGYPDDAPFSSQSFTPGDSLDLISEGGGLEGNKIFQISFTAQDVPAGNAILSLRFYNGEGILIKTFEDLGIQICKNLETKTWIIAGREEAILMLSKDDFLSSDTDLAKVSIQYNGAFLLANVDDLVPGDPPASLPLTFESDQYYYSIADYIYTSSTSFNLYVTLKNPGQTLKVSLNGLPQAPASSIPSEYYRFYFPPKDRKLNQILLTVTTMDGLHSRSYTIDCIQAGPGTEQQTMFFVSQGGLDTNGGTSREDGFASVQHALEVIHAVSTSSWPQMLSPGTGPEPALIIVSGMISYTAGTVGNKGMIDTKGIIYTDEYLNLPPIILQGNPQYPGTIDAGGNKRVLYIDGSTSVNITLKENLTLTNGNAVSDNGIGGGVYVAGGGLYTHRFTMDGGIIGRSGDVKNTAANGGGVAVDSGSFFIMNGGTISGNTAGTGCGVYTMGSFTMNGGTISGNTAGIGLGSGTGGGVSVVGGSFAMSGGTISGNKATGVSNNTGGGVYVGSGSFTMSGGTVSGNTADKGGGVFLANASSFILYGGTVSGNTAATGLGSGGGVYNYQGNFTMSGGNISGNKATGASNNTGGGIYNDQGNFTMSGGTISGNEAGSGGGIYSTGIGSISTMTGGEISGNTASGLGGGVVLYDAFNLSGGKIAGNTALHGGGLAVETGAFTMEGGSVSGNTAGGEGGGVRSSTAGTFTLKRGTVSGNTADKGGGVDVNDTGIFNMDGGSVSGNTATGGEGGGVRYTGSGTFTLKGGTISENTATTGSGVYHNGNTFYLSDKGIVAENNDVYLATGKTITINDYLSTYFRWSAVVARLTPANYENFTNPLLSSSLTFFQAYTALFTITPPPGDENTDKYYIGDLGNLSKIRKAPLNQFVRINGGTVTANIGEAQGPFANASPTTPVTVKTFMMGTTEVSYELWWTVMQRSDPGYNFGTNYQEGSRSGASKRDPTSRRYEPVTNISWADALVWCNAYSELTGRMPAYRYSETYSVDIRKRGQTVQSSSTVSSPSDVVLNAYYNGYRLPTEAEWEYAARGGLGAASWNYDWPGASLVADLAWYAANAGYTHPVAQKTANSLGLYDMAGNVAEWCWDGYTGSSDDNRVLRGGYYNSTADGLKVSARDSDHFKTTPPTNTGLRVVYTP
>NC_015578.1|WP_015706412.1|238937_239774_+|hypothetical-protein
MMRHFFSHKTTLPGLGLAGIALMGLALLSGCDTLFGEPEENVLTKIEDAVWQATAPDIGVIVGVRANAEGRTNPAGPAQAKQKVPFAVRFTVNDEYQFIRWQAFQGGVLLAADQAVFENPAAAETWLSIQGTGNSFTVQPLTLARPRVDTTNLPQGGSLRVALNYPVRIYFAGPLAPDSLILEETGKPNFTNISITGKLSYGQGADVDLTDRFSAALGENDSFLVLTPLPDNPLPGNCNVTVTLGADIQSIHTIDGETYRIPLLKPVTLNYGVHDRAD
>NC_015578.1|WP_041611338.1|239854_241756_+|hypothetical-protein
MTFLGILGNLSALDLSLRGRGLGFFPLGDGAADYSFGGGGEFLFDVDLSRLFPSSLGLGFTLDAEAGINSSPLSSGEGEDLRLYSLGAGAGIHFFPLSRLMVRGEGAGGYYQGYFQDATSGSWWLRAGGEAGFRITPRLISSLSAGYRYYNDKYGGTMNSGIYLGITLQINLGTGSGGGADATLIQDEPIFPLFLSLYQQNAGGTLRITNHESAELRNVRVSFRAQGYSSSEFLCGTLAQIPRGRTMELPLLADFSPELLNMTENGRILGEVVVRYELLGAERSALTGISVRVNNRNSFRWVDPGALAAFVSPTSPEILELSRYLSGIARVHQQTALNPKMQFGIYFFEGLREAGVRLSLNPATPYAGYHTGTDSPIQKDSIDSIQFPLQTLAFRGGDVDDLGLLYAALLESAGIRAALIPMNNDFITALSLGISSAQAASLFNGTDKLLIINDEVWLPLSFSYFNNGFFDSWTAAADQLTRAFSNGEWVDIIILENAWPSYPPVNLPPQQVRFTPPVETATIREAEAVLGRYISAEILPKIEALNASLRSGATGALYNQLGLLYTRAGMQREARTAYQQGADMNYVSSMLNLGNMAILDNDTALAERWFRQALSLAPDNAAAKRMLDQMAAD
>NC_015578.1|WP_015706414.1|241758_243375_+|hypothetical-protein
MKTRPLTIVLLLVLPVFPLLAEEGSRPREDSRLDFHLVPGTSLPLDSRGLFQPGLAASIALDWSFLPFLGISGQAGFSSIPTNAEDAVTLIEGSLGPLLRWRLLDRLSLGLRGQVGLYQFQWREYSDFRLRLGGNLSASFHISPLISLTAFAGYTSYLYQPDPFLDSINLGLGVSFNLFEITRKRTRIQGEQIMRNMVFPVSYAWYENNPVINMRITNLEPNSISNARVSFFLERYMSQPTIAADIPRLAPGESADITVTALFNETMLDLTENISANARILINYQSLGSLKEAAIPVQLPIYHRNAMTWDDDRRAASFVSPRDPIALLFSRHVGSLVESRMQGDYNRNIQYALGLFEALNLYGIYYIIDPASSYAELSDDAGQLDSLNYPFETLFYHGGDCDDLSILFCSLMEVQGIDTAFITIPGHIYMAFDSGLSEDEGRLSSFAPDLISYEGRAWVPLEITIPGSGFSQAWRVGSREWQNAAGEREIFPLKEAWSLYPPVNVPGAGSHNILLPDAAAINAAFEASLAKVKSLPKN
>NC_015578.1|WP_174269880.1|243465_244494_+|hypothetical-protein
MTYKRTAVLVTLGILLAGFIAGCATPPEPEPAPAPAPRRDPPPVRIAQPAPPPPPEIPIRPITREILDLINKSTYEMGDLQYYISAPITLEHGKGLQYDIEIYPGGEGIIQETNAQEKIIIPKDTGGVLIPDWATRPMGAPRALKICFDDNDAHTLTFRENPADNRFYLAFREDRVYGEFTDYGEESYKLSLSSEIPYLYVRVDEISNTQPRTKELRGRYLGPREAPAESTELPSYLMEDAELPSYLQEPVSEPAPEMLPEQVPAAVQTPVVETAPVAEPVPAAQSARRTPENQNASNRPPRPPTAVSAPAPAPPRTPASVAPVPEPADEDEELDLEALLGM
>NC_015578.1|WP_015706416.1|244554_245904_+|galactokinase
MTGRELLEAIQAAKARGIFEGLYGPGTAETAQCRYASLIKGILDDAPQGFPEADFPETKDGLRVFTAAGRTELGGNHTDHNRGKVFAASIQMDAVAIVAPRSDKRVLFRSGGFPDVQVDLTDLSPRPEEKGTTEALVRGIAAELTRRGTAVGGFTANAASTVLPGSGLSSSAAVEVLFGRIFDNLYGGGKRASLEIAQIGQIAENSYFGKPSGLMDQTACASGGAVAIDFEDPAKPKVKGVNFDLESLGYALAVTDTRGSHADLTPDYAAIPGEMKAVAAFFGKQVLREVDPREVLAHAPEIRKAAGDRALLRAFHYFNENRKVDAMLAALEKAVSSSGPEKQAAFAAYLDLVNQSGDSSWELLQNVYSPKNPAVQGVSVALAVTRDFLAESASIGACRVHGGGFAGTIQSYIPLDRLGAYKAVMEGIFGEGSVTVLRIRPVGAAELYF
>NC_015578.1|WP_015706417.1|245957_247148_+|DNA-polymerase-IV
MTYFIHADLDAFYASVEQLDHPEYCGKPVIVGGLPGDRRSVVSTASYEARKFGVHSAMPVAQAYKLCPQGIYLRGNMKRYREKSDEVMAVFSDFTPDVKQISIDEAFLDITGTEKLFGPPGLMAKKLKEAVRSRTGLTVSLGLASNKYVAKIASGLSKPDGVSIVAPGEEERFMSALPVSKIWGAGSKTQEQFKKRGLKTCDDILRLSLDQLKSQFGAAFGLFLHRAVRGQAAAAFEDERGTHSMSAERTFPYDLYDEFTIETTLFEICETLMFRLLDLNWQSRTIFIKIRYEDFSTESAQETLPRPVSTINELFDHLSALFRRKRQDGRGVRLIGAGLSNLETDHTPLQRELFDTGNEKEQALEKYILEINKKFPGAALRKGRSLMERASKPADE
>NC_015578.1|WP_015706418.1|247265_248966_+|hypothetical-protein
MRNKLYIILIGILCFGVMTNCEIPESVDIKGQPGLYINLGSPFGSDNLVKEYLSPEGIAEQMGNSGSDSDIYQYTASDFLFNGATIDINNTQTYLIQFPIANQDLDFSEYLKELNTDLDFTVYQAGIVPEPVSIPLEMKDMASWVETIDINDIPGGKISKIILKDKDGAPDLVKSLEKTIKLRVKNLGISTAGDYKFGRPDKDPVDGKYILVFDAEVPVTEYSPKDKTDPIKIDTQFVGASTKTGTFSIDVDLQWKRAVVNPGEVGDEGTQKGEFTGLKFSDLTEFLGGVEFKNVPGYLYVSGLDNANATIELKAEILGTSKKTETLIPLKEIKQSHKLELNSDVPEKKIYSGAIPPVEFSFPLEDVFNAKGDVTLKYEIKIVQMTMDNDGTPKDPIKIDLVIVLPLDFTVPPAPAGVNYNFPDPKTENLISYYPLNLSALPDPDSNDDMLNREEGEDNLFESLKEAKIIINQVQNDVIDGLILAVKTKDPDHKKAEVIPLNDGNFQIITFTPSDLAIPFNPGFLLLVKSSDPNLTVKRVASDADPKFDFNLALQARTDLNISQKF
>NC_015578.1|WP_015706419.1|248978_250403_+|hypothetical-protein
MKKLTLFFIISSLAWGLYAQEAPLEEVVAESEDTGIVLDDSQSEYSQLEEIAAKAAAEAEASALEAETEFAQDEPVQEKNQSALAKFGGQVLDYFNKPATTRHNEPLRGVEFGYDFTGGFGNSLIGTGDIFKKNIVINLNTWSDQIQDRGVDFGFDFDFHTFINVNIGKGAWGLGEFINSDSRFDINLPKDLFELLSKGNWDNHNQSGNFSVSGATFAEAGLKWYGTFLDKKLRVGVAPAWYLPLVYIPKSSLSYVLQADPSLRVAVSGDMAVYMPFSLDPFELKDLGGADISLSGEYALFPIIDVGTTISHIPFVPATLSNGQTLTFSNDIIPETTNLLSDFPDIGDIDPDTSSFTDANKIVLRPLRVDFYVLYRPLRRDLLTIKPNIGFTAINPSEETYFNGAIELQLNLARIFFVHLNTGIEEGYWRHKLGFALNLHAFELDLEGVLKSQDYLKSYQASGLGVTLGMKVGF
>NC_015578.1|WP_041611340.1|250816_251935_+|S-methyl-5-thioribose-1-phosphate-isomerase
MNVNGKHYRTIWLKEEDKRVVQIINQLVLPHKFEILDLHRVEDVRRAIKDMYVRGAGLIGAAAAYGMYLAALEASDSAFERDLLASAQILKATRPTASNLAWAVDAMLAKLTGPSGDMEQKRVEARSLAGEIADQDAEYCRNIGLHGAEIIAGIAEKKKGETVNILTHCNAGWLAFVDYGSALSPVYTAFDRGIKVHVWVDETRPRNQGASLTAWELAQHGVSHDLIPDNAGGHLMQHGMVDMVITGADRVTRCGDAANKIGTYLKAVAAKENGVPFYVALPSSTFDFTMRDGLREIPIEERDAAEVRYVSGKTSGGIIETVQICPDATPARNWGFDVTPGRYIRALISERGVCEASERGILSLYPERAANG

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Crispr_ID: NC_015578_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015578_2

237160-237280

Orphan

Consensus_repeat	Method
TATACAACTACCAGGGTAACTTTACCATGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015578_2

>merge|NC_015578|2|237160-237280|CRISPRCasFinder
TATACAACTACCAGGGTAACTTTACCATGAGCGGGGGAAATATCAGCGGGAATAAAGCCACCGGCGCTAGTAACAATACTGGCGGCGGGATATACAACGACCAGGGTAACTTTACCATGAG

>NC_015578|2|2|237160-237280|CRISPRCasFinder
TATACAACTACCAGGGTAACTTTACCATGAG	CGGGGGAAATATCAGCGGGAATAAAGCCACCGGCGCTAGTAACAATACTGGCGGCGGGA
TATACAACGACCAGGGTAACTTTACCATGAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_015578.1\|WP_041610961.1\|222832_223498_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015706404.1\|223547_225371_-\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|214599
NC_015578.1\|WP_015706414.1\|241758_243375_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015706406.1\|226518_226872_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NC_015578.1\|WP_015706417.1\|245957_247148_+\|DNA-polymerase-IV	unknown	unknown	gnl\|CDD\|176459
NC_015578.1\|WP_015706407.1\|226880_228842_-\|ATP-dependent-zinc-metalloprotease-FtsH	unknown	unknown	gnl\|CDD\|273520
NC_015578.1\|WP_041611340.1\|250816_251935_+\|S-methyl-5-thioribose-1-phosphate-isomerase	unknown	unknown	gnl\|CDD\|235578
NC_015578.1\|WP_148257205.1\|231925_234967_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|182059
NC_015578.1\|WP_015706416.1\|244554_245904_+\|galactokinase	unknown	unknown	gnl\|CDD\|223231
NC_015578.1\|WP_015706412.1\|238937_239774_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015706418.1\|247265_248966_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015706403.1\|221644_222757_+\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|379234
NC_015578.1\|WP_041611338.1\|239854_241756_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|276809
NC_015578.1\|WP_041610960.1\|220758_221574_-\|phosphohydrolase	unknown	unknown	gnl\|CDD\|225831
NC_015578.1\|WP_041611337.1\|225620_226424_+\|M15-family-metallopeptidase	unknown	unknown	gnl\|CDD\|379247
NC_015578.1\|WP_052299682.1\|218540_220751_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224225
NC_015578.1\|WP_174269880.1\|243465_244494_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237865
NC_015578.1\|WP_015706421.1\|251927_252545_+\|class-II-aldolase/adducin-family-protein	unknown	unknown	gnl\|CDD\|376358
NC_015578.1\|WP_015706419.1\|248978_250403_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015706409.1\|229041_231918_+\|bacterial-Ig-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|369401

Protein	Function_ID	Function_description	E-value
NC_015578.1\|WP_015706404.1\|223547_225371_-\|HAMP-domain-containing-protein	gnl\|CDD\|214599	smart00283, MA, Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.	1.36853e-44
NC_015578.1\|WP_015706406.1\|226518_226872_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	1.2674e-08
NC_015578.1\|WP_015706417.1\|245957_247148_+\|DNA-polymerase-IV	gnl\|CDD\|176459	cd03586, PolY_Pol_IV_kappa, DNA Polymerase IV/Kappa. Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.	3.60034e-147
NC_015578.1\|WP_015706407.1\|226880_228842_-\|ATP-dependent-zinc-metalloprotease-FtsH	gnl\|CDD\|273520	TIGR01241, ATP-dependent_zinc_metalloprotease_FtsH, ATP-dependent metalloprotease FtsH. HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides].	0
NC_015578.1\|WP_041611340.1\|250816_251935_+\|S-methyl-5-thioribose-1-phosphate-isomerase	gnl\|CDD\|235578	PRK05720, mtnA, methylthioribose-1-phosphate isomerase; Reviewed.	2.04238e-165
NC_015578.1\|WP_174269880.1\|243465_244494_+\|hypothetical-protein	gnl\|CDD\|237865	PRK14951, PRK14951, DNA polymerase III subunits gamma and tau; Provisional.	5.22315e-05
NC_015578.1\|WP_015706416.1\|244554_245904_+\|galactokinase	gnl\|CDD\|223231	COG0153, GalK, Galactokinase [Carbohydrate transport and metabolism].	8.45312e-38
NC_015578.1\|WP_015706403.1\|221644_222757_+\|VWA-domain-containing-protein	gnl\|CDD\|379234	pfam13519, VWA_2, von Willebrand factor type A domain.	4.84153e-09
NC_015578.1\|WP_041611338.1\|239854_241756_+\|hypothetical-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	2.48812e-07
NC_015578.1\|WP_041610960.1\|220758_221574_-\|phosphohydrolase	gnl\|CDD\|225831	COG3294, COG3294, HD supefamily hydrolase [General function prediction only].	3.21199e-68
NC_015578.1\|WP_041611337.1\|225620_226424_+\|M15-family-metallopeptidase	gnl\|CDD\|379247	pfam13539, Peptidase_M15_4, D-alanyl-D-alanine carboxypeptidase. This family resembles VanY, pfam02557, which is part of the peptidase M15 family.	2.77727e-15
NC_015578.1\|WP_052299682.1\|218540_220751_-\|hypothetical-protein	gnl\|CDD\|224225	COG1306, COG1306, Uncharacterized conserved protein [Function unknown].	4.29302e-100
NC_015578.1\|WP_148257205.1\|231925_234967_+\|hypothetical-protein	gnl\|CDD\|182059	PRK09752, PRK09752, AIDA-I family autotransporter YfaL.	0.000637979
NC_015578.1\|WP_015706421.1\|251927_252545_+\|class-II-aldolase/adducin-family-protein	gnl\|CDD\|376358	pfam00596, Aldolase_II, Class II Aldolase and Adducin N-terminal domain. This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.	1.00257e-20
NC_015578.1\|WP_015706409.1\|229041_231918_+\|bacterial-Ig-like-domain-containing-protein	gnl\|CDD\|369401	pfam07523, Big_3, Bacterial Ig-like domain (group 3). This family consists of bacterial domains with an Ig-like fold. Members of this family are found in a variety of bacterial surface proteins.	3.77787e-06

>NC_015578.1|WP_148257205.1|231925_234967_+|hypothetical-protein
MKTRMLPIAFIALILAGCSNPLTSPRKENPWTPGAGPGTGQVRVIIDNRNSTAPRTIVPQDPDFVYTLSFTKGGVTEEFPVENPGGQIVDLELGAWTLRVQGTKDGEKVAESDDISVNLGAAGSSQEIRALIHPATGAGTSGGSFKYDIIFSDISSITNAKLTLTRLSDLTVTTISNLATNGAGTLSALESGYYRLKVELTRDRQTAVRGDIVHIYPKIETFQSYIFTADDFAPGIFLAGRVIHSFIGYTAEEIQFFNNDSHNLIGSATIDSQGNWAGVISGTPNWVWYKVRFSGTGGESYYSSEQRYPQTGDLDLAGVENIQLYPEFEGMINIEGVISSGPLGLSFSGELRTADSGGDVEISISNPRNDTVTWSGAITDAWGSRQALTLSDGISGKSYRRFTAPTQAGLYTVTMAAALNDRVYSGSFPLYVWGQGELGPEEVYDWAGLSNAIVSMAGASKIVIIKNSFPFSGKITITGGTFTIIAAKPIVLIRASDNGPFFELSNGGELILGLPGSGGTLTLDGYSASAINYPIINVNGGHFTLNANAALQGNTNTYTSGFGENGGGAVIVEGGIFTMNGGSISGNAANETTDGSSGGGGVLVVNTGSFIMNGGVISGNTTNQSGGGVLVDSGSFTMNGGLINGNAAISKNTATGENSGSGGGVSALRGSFTINDGAISGNAVRKKGGGAYIFSNTFIMNGGSISGNTASGGIYGSLGGGIYVRESRFTLNDGFIDENQAERGGGIVIEGISNVPTIFTMNNGSIRRNRAEKHGGGIEILGTRISVTINGGAVEENTAEGSGGGILVGGYNASVTMNGGAVSNNTAMGSGGGILVGESNVDAESRSQSGTFTLKNGSITNNRASIGSAVYLGGVPWGALHIPSTANGFIATGGVISGNKNTSTSSLEDTPRFGVYIQYGNYFSMEGGFLFGKDNYFYLSNGANLSLTGTSALAAEKISIEPEISAPGTVLVDGPKALLDLDKFAYFSPGANKELEVINTVNVYGAIVIKGGE
>NC_015578.1|WP_015706409.1|229041_231918_+|bacterial-Ig-like-domain-containing-protein
MAFLVASCDLFMNKPERNIRDDIKTTVEIANAPIISVTVEAVPAAAGRTNPEGAHTEKQRVPFTVSFIISDEYSFITWQAWQQVNGVETLLSGDQVQFSATGNENFETQVTIINTGSAISVRPLVIARPRMVFNNLPGGEYPRTVTNYPVRIWFAEPLSRESLLDPANSINYKNISVTGKGRFGADPEIDLKGYFNLGLNDDGTLLTLKVNTDKGYIGLPGNTNVTITLETGILTGGEHGVSLLNPVVLHYGVGDKPDRDPPVVEILRGFFQSGGSDKMIDDGDSFRFVYDGSYTFSVEAPTRLAPLDANGKATAIYLVFKAYDELGEIQGVTVSENRIYDLEGGNPVYETDTENVTVYQDYDQFHESLPLDQMATYQSLLSPGESPPLVVRHVIKSAEDGILDLIILPEDSVGNRADPMAAYEPFQAPQRIRVALDFPPDPVKSLTGEYKEPNLEISWANPQAKDLAEIRLSYRNNSAGTPEETIVLPPVSVDYPIGVVKGNNYTIRLTAVDHGDKESSPEEITMTASAPPVATYRIRATASAGGRVSANPIRSAEGGLVTLTATPDRGYRFRGGSLSAKLAEDGASIPLSGNTFTMPAGDVEVSAGFEADEYAITGFNANGGTISAVPAGTRITAGKTVTLTVTPDPGNVLKTLAVKRTDTNGAVMVSGYNNVYTFTMPAGNVELSALFEPLPSNAYLINMAPWINGGFISSPLNYGIAGSLITLTVKPVSGFQIKPNARPTVTRTDTNVKLPVYGATGATAYTFTMPAAAVELSAEFEGLPITIQSPPNKTAFNLGHTLTEADLEGLVVAAVNTNGSSQPLPIALNNISGFNSNVSGVQTLTVTVNGKTASFTVTIRDQGNISIDLDDPNLGLPKDIVISKTSAAPNPKTVTVSVYGTYTAYNWYVNNTEISDSKDRPILILDASKYPLGRNYLRVEVRKGNVYYSREIDFKVEG
>NC_015578.1|WP_015706407.1|226880_228842_-|ATP-dependent-zinc-metalloprotease-FtsH
MSDYQNDGSGNDKKKPKNSGPQFPFGGPKLPDPKKFGGWRFSIVYILILVVGMSLFNYVFLNKVNPTIDFSEFKNKIVSGEIKRVEMTDSYFTGYTAAQKTVAPTPGLRNPYGSSPDAIFRTVPLNDPDIIKLMDEKGVSYYAVSREGSTVLNLIFSWVLPIAFFFFIWRFLMKRLGNMGGNVLSVGQNRAVIVAEGDIVTRFPDVAGVDEAKDELVEVVDFLKNPKKYTDIGGKIPKGVLLVGPPGTGKTLLARAVAGEAGVSFFRMSGADFVEMFVGVGAARVRDLFKQAREKAPCIVFIDELDAIGKSRLNNIAGGNDEREQTLNQLLVEMDGFDATSGLIILAATNRPDVLDPALLRPGRFDRQVLVDRPDLKGREAILRIHAKAVKLDPQVDLAAVARGTPGFVGADLANIVNEAALLAVRGGRQVVSQKDFEEAIEKTVAGLEQKNRIISDDERRIVAFHETGHALVAAFTPGSDPVQKISIVPRGFGALGYTLQMPVEDRYLMTEDELLGKIDVLLGGRAAEELVFSRISTGAANDLTKATDIARKMITDYGMSARFKNVALTQRGAGMMGGAAQEPMFHREYSEATQQYIDEEIARMVETRYAGVKDTLKQRRDLLDLVGAQLLEKETLDEKEFKGLIGQPVAAV
>NC_015578.1|WP_015706406.1|226518_226872_+|helix-turn-helix-transcriptional-regulator
MLSNNEETKIRGLLSKNIKRLRAKNSLSQMNLAIQAGLTHNFINDIESGKKWLSPKTLAKLSMALQAEPHEFFAPEITIPEADSGTLSEYLDDVTETFQRMVEDIKERYFQDTDSKD
>NC_015578.1|WP_041611337.1|225620_226424_+|M15-family-metallopeptidase
MKALAAAYPGRVGAAVFRKGTPADTGDWAVQIRETWFYYAQGRLLPEELRNRYAEYDPQPFYNYPAELPAWKDPSPEETERFRNSAQMRQANPPKRSQFFFDALWRSSTREEAYERVKTMRFLGKSVTVHYSIMEELALVEERILWEANNSTLVRQWVNRLDTLAGWNWRSIADTQSRSFHAYGAAVDLLPASQGGLQSYWLWTSQNYPAWWAVPYEKRLHPPAAVIRAFEEYGFIWGGKWLFFDTMHFEYRPEILLLNNMPVKAAY
>NC_015578.1|WP_015706404.1|223547_225371_-|HAMP-domain-containing-protein
MKKVVSLKTQFMVFFTAFILVLSTAITVLALRESLEVATTIFIREGIAVINKAVDMVDGDAFERLSASLDENDPFYEDTRLELLFLKENSVTLYLYTMAPVQGSVYKYIIDGSAPPDDEENFSPLGAEEDTSSYDKAFQRTWKTGTQQSGGMVKQGGWGWLVSVYSPIKNSRGQMVGIVGCDFEAQSLFDMIQTQTIRQVALGVILSLIGIVITWFFLRALFSRLGTVSSILKSVSEGEGDLTKRITIKRMDEIGTLASFFNQTLDKIRNMVVTIKEQTVSLSDIGSELSSNMTETAAAINQITSNIQSIKGQALNQSASVSETSSVMEKVTVNIEKLNSQVEKQTSSVSQSSSAIEEMLANIQSVTQTLVRNAENVEELIAASEVGRTGLQGVSADIQEIARESEGLLEINSVMQNIASQTNLLSMNAAIEAAHAGEAGRGFAVVADEIRKLAENSGQQSKIISDTLKKIKESIDKITKSTNTVLNRFEAIDTGVKTVSDQETHIRNAMEEQGQGSQQILEAIAKLNDITQQVKQGSLEMLEGSKEVINESKNLELVTQEITNGMNEMATGAEQINSAVNRVNTISGDNQEHINTLATEVARFKVE
>NC_015578.1|WP_041610961.1|222832_223498_+|hypothetical-protein
MRVFKVALMAGIFFAFFLLPLLPAEEPDTGTLLDTIQELATPIPETLKNEAEAEEYEDFDDFDEETILDFEGPEITIFYNERNEADYIEVKTDEKIEEYHYLSHIKYSDLIFVLSDLLRRITREGYQWARAPAISYEKSDEIVLLYRKDLVNDMVYGIVQFPDFKVWLSAIRQQDREHRYNAGSGRDMLMLVYAFAQCLAQAEQTLGISQVEYTMRFFKPE
>NC_015578.1|WP_015706403.1|221644_222757_+|VWA-domain-containing-protein
MRRTCSILAGIFFFLAPLFIFSQDLSIQTEDLRIEQRVDGGFHLFIRKKPGINSVLLTESTRDPSLNEDNYAYRAAEWNPINGDEIRLLDGVPIARESGIWSLIDSTPEPDSQFGQAFRIYIPWILYYGYSDTRHGEIYVVDGTYLNIRAFTLPYGDYQGSFRDNPFAVLVTQQPLAGPPEGNYMKDTVDSFTEIVAGKGDLIYSTGADDLVTKIGEILEEEKGKKVDIVLCLDTTGSMRDDIDSVRRLLIPLLEGMIADFNGFRIGMVLYKDYYETYLTRVVGFTADFSKFRTTLNNIQVGGGRDIPEAVHEALYEGATKFPWNAESRLLLLIGDAPPHPRQRGKISKEMVDKAVEDKGLKLSAIILPQ
>NC_015578.1|WP_041610960.1|220758_221574_-|phosphohydrolase
MRSQKGNVLDGKIIEMITGFGLSGKAVEAAKLVLEDAEVQAMQEYANTVSIMRLNYNDHGPVHMRTVALNALIMMGLLRDAGIKTNLEKEDCGTFEDSLIAVLLASVLHDLGMTIGRQDHELHSVYLAYPILDRLLRKVYAADLQKLVTVRSLALEGISGHMGTRTIHSLEAGLIQIADGCDMTKGRARIPLIVAGGPRPGDIHQLSANSIEDVRISRGTEQPIRIDIRMSGEIGLFQIEEVLLGKIAKSTAKIYTELYALMDKGELKRYL
>NC_015578.1|WP_052299682.1|218540_220751_-|hypothetical-protein
MVLKSPRPFNSMAVTFLLSCSLLILLSPGAGTQTSLPAQNTWPTVIGTDKGLYGMDRLGIVRPLWTGGAVRKILKTANYWAILGDQGILVSTDLLRWETRNRGLPVKTIKNYDDGQKTFTYMVQELKDLEALPEDPETLVCATKDTVFLSRDAGKTWESLGAPPYRTNGIKAVAATLLPAPGSAQPALTVFLSHSTYGIYYRALDSRNAGWVEMNQGLERLETTTNPDEVSDIAVAVPTGSAGNGSPRIYVSQTFRRRIYQLNWEQKRFTPIWSDSADFGTVDSLDIGAQGIRFVQEGAVMELNYPPAVISAVSSTSLVTRDRPDLNSFIRQIPSAWGIKPSSLISWGSAARIDEDPVTLSELWLLDTGTGKEAARGKQGLYLPVNHAMESRTLAPYLKVIEESALDMVVIDMKDDYGRLRFSPNNPAIPEKGRVFRPVDIDAFLKTMQDRGIYTVARIVVFKDPELARKEGGKFAVWDSHNRKPWVGYYDQRQPKGTGADKDSSYETAILSADDPTYEILRTYYDERWVDPYSEEVWEYTAAIAGELIDRGFDEIQFDYIRFPTDGANLGDAQYRWRENGMDMDSAILSFLRHIRSRITAPISIDIYGANGWYRTGARTGQEVELLAPYVDVICPMYYPSHFEQDFLAQSPAEQRPYRIYFQGSQRTERIGRGQIIVRPYVQAFFLNVSYDRQYYNPDYVRRQVEGVRDAGANGLTYWNNSGRYDDIPLRGAPGL
>NC_015578.1|WP_015706412.1|238937_239774_+|hypothetical-protein
MMRHFFSHKTTLPGLGLAGIALMGLALLSGCDTLFGEPEENVLTKIEDAVWQATAPDIGVIVGVRANAEGRTNPAGPAQAKQKVPFAVRFTVNDEYQFIRWQAFQGGVLLAADQAVFENPAAAETWLSIQGTGNSFTVQPLTLARPRVDTTNLPQGGSLRVALNYPVRIYFAGPLAPDSLILEETGKPNFTNISITGKLSYGQGADVDLTDRFSAALGENDSFLVLTPLPDNPLPGNCNVTVTLGADIQSIHTIDGETYRIPLLKPVTLNYGVHDRAD
>NC_015578.1|WP_041611338.1|239854_241756_+|hypothetical-protein
MTFLGILGNLSALDLSLRGRGLGFFPLGDGAADYSFGGGGEFLFDVDLSRLFPSSLGLGFTLDAEAGINSSPLSSGEGEDLRLYSLGAGAGIHFFPLSRLMVRGEGAGGYYQGYFQDATSGSWWLRAGGEAGFRITPRLISSLSAGYRYYNDKYGGTMNSGIYLGITLQINLGTGSGGGADATLIQDEPIFPLFLSLYQQNAGGTLRITNHESAELRNVRVSFRAQGYSSSEFLCGTLAQIPRGRTMELPLLADFSPELLNMTENGRILGEVVVRYELLGAERSALTGISVRVNNRNSFRWVDPGALAAFVSPTSPEILELSRYLSGIARVHQQTALNPKMQFGIYFFEGLREAGVRLSLNPATPYAGYHTGTDSPIQKDSIDSIQFPLQTLAFRGGDVDDLGLLYAALLESAGIRAALIPMNNDFITALSLGISSAQAASLFNGTDKLLIINDEVWLPLSFSYFNNGFFDSWTAAADQLTRAFSNGEWVDIIILENAWPSYPPVNLPPQQVRFTPPVETATIREAEAVLGRYISAEILPKIEALNASLRSGATGALYNQLGLLYTRAGMQREARTAYQQGADMNYVSSMLNLGNMAILDNDTALAERWFRQALSLAPDNAAAKRMLDQMAAD
>NC_015578.1|WP_015706414.1|241758_243375_+|hypothetical-protein
MKTRPLTIVLLLVLPVFPLLAEEGSRPREDSRLDFHLVPGTSLPLDSRGLFQPGLAASIALDWSFLPFLGISGQAGFSSIPTNAEDAVTLIEGSLGPLLRWRLLDRLSLGLRGQVGLYQFQWREYSDFRLRLGGNLSASFHISPLISLTAFAGYTSYLYQPDPFLDSINLGLGVSFNLFEITRKRTRIQGEQIMRNMVFPVSYAWYENNPVINMRITNLEPNSISNARVSFFLERYMSQPTIAADIPRLAPGESADITVTALFNETMLDLTENISANARILINYQSLGSLKEAAIPVQLPIYHRNAMTWDDDRRAASFVSPRDPIALLFSRHVGSLVESRMQGDYNRNIQYALGLFEALNLYGIYYIIDPASSYAELSDDAGQLDSLNYPFETLFYHGGDCDDLSILFCSLMEVQGIDTAFITIPGHIYMAFDSGLSEDEGRLSSFAPDLISYEGRAWVPLEITIPGSGFSQAWRVGSREWQNAAGEREIFPLKEAWSLYPPVNVPGAGSHNILLPDAAAINAAFEASLAKVKSLPKN
>NC_015578.1|WP_174269880.1|243465_244494_+|hypothetical-protein
MTYKRTAVLVTLGILLAGFIAGCATPPEPEPAPAPAPRRDPPPVRIAQPAPPPPPEIPIRPITREILDLINKSTYEMGDLQYYISAPITLEHGKGLQYDIEIYPGGEGIIQETNAQEKIIIPKDTGGVLIPDWATRPMGAPRALKICFDDNDAHTLTFRENPADNRFYLAFREDRVYGEFTDYGEESYKLSLSSEIPYLYVRVDEISNTQPRTKELRGRYLGPREAPAESTELPSYLMEDAELPSYLQEPVSEPAPEMLPEQVPAAVQTPVVETAPVAEPVPAAQSARRTPENQNASNRPPRPPTAVSAPAPAPPRTPASVAPVPEPADEDEELDLEALLGM
>NC_015578.1|WP_015706416.1|244554_245904_+|galactokinase
MTGRELLEAIQAAKARGIFEGLYGPGTAETAQCRYASLIKGILDDAPQGFPEADFPETKDGLRVFTAAGRTELGGNHTDHNRGKVFAASIQMDAVAIVAPRSDKRVLFRSGGFPDVQVDLTDLSPRPEEKGTTEALVRGIAAELTRRGTAVGGFTANAASTVLPGSGLSSSAAVEVLFGRIFDNLYGGGKRASLEIAQIGQIAENSYFGKPSGLMDQTACASGGAVAIDFEDPAKPKVKGVNFDLESLGYALAVTDTRGSHADLTPDYAAIPGEMKAVAAFFGKQVLREVDPREVLAHAPEIRKAAGDRALLRAFHYFNENRKVDAMLAALEKAVSSSGPEKQAAFAAYLDLVNQSGDSSWELLQNVYSPKNPAVQGVSVALAVTRDFLAESASIGACRVHGGGFAGTIQSYIPLDRLGAYKAVMEGIFGEGSVTVLRIRPVGAAELYF
>NC_015578.1|WP_015706417.1|245957_247148_+|DNA-polymerase-IV
MTYFIHADLDAFYASVEQLDHPEYCGKPVIVGGLPGDRRSVVSTASYEARKFGVHSAMPVAQAYKLCPQGIYLRGNMKRYREKSDEVMAVFSDFTPDVKQISIDEAFLDITGTEKLFGPPGLMAKKLKEAVRSRTGLTVSLGLASNKYVAKIASGLSKPDGVSIVAPGEEERFMSALPVSKIWGAGSKTQEQFKKRGLKTCDDILRLSLDQLKSQFGAAFGLFLHRAVRGQAAAAFEDERGTHSMSAERTFPYDLYDEFTIETTLFEICETLMFRLLDLNWQSRTIFIKIRYEDFSTESAQETLPRPVSTINELFDHLSALFRRKRQDGRGVRLIGAGLSNLETDHTPLQRELFDTGNEKEQALEKYILEINKKFPGAALRKGRSLMERASKPADE
>NC_015578.1|WP_015706418.1|247265_248966_+|hypothetical-protein
MRNKLYIILIGILCFGVMTNCEIPESVDIKGQPGLYINLGSPFGSDNLVKEYLSPEGIAEQMGNSGSDSDIYQYTASDFLFNGATIDINNTQTYLIQFPIANQDLDFSEYLKELNTDLDFTVYQAGIVPEPVSIPLEMKDMASWVETIDINDIPGGKISKIILKDKDGAPDLVKSLEKTIKLRVKNLGISTAGDYKFGRPDKDPVDGKYILVFDAEVPVTEYSPKDKTDPIKIDTQFVGASTKTGTFSIDVDLQWKRAVVNPGEVGDEGTQKGEFTGLKFSDLTEFLGGVEFKNVPGYLYVSGLDNANATIELKAEILGTSKKTETLIPLKEIKQSHKLELNSDVPEKKIYSGAIPPVEFSFPLEDVFNAKGDVTLKYEIKIVQMTMDNDGTPKDPIKIDLVIVLPLDFTVPPAPAGVNYNFPDPKTENLISYYPLNLSALPDPDSNDDMLNREEGEDNLFESLKEAKIIINQVQNDVIDGLILAVKTKDPDHKKAEVIPLNDGNFQIITFTPSDLAIPFNPGFLLLVKSSDPNLTVKRVASDADPKFDFNLALQARTDLNISQKF
>NC_015578.1|WP_015706419.1|248978_250403_+|hypothetical-protein
MKKLTLFFIISSLAWGLYAQEAPLEEVVAESEDTGIVLDDSQSEYSQLEEIAAKAAAEAEASALEAETEFAQDEPVQEKNQSALAKFGGQVLDYFNKPATTRHNEPLRGVEFGYDFTGGFGNSLIGTGDIFKKNIVINLNTWSDQIQDRGVDFGFDFDFHTFINVNIGKGAWGLGEFINSDSRFDINLPKDLFELLSKGNWDNHNQSGNFSVSGATFAEAGLKWYGTFLDKKLRVGVAPAWYLPLVYIPKSSLSYVLQADPSLRVAVSGDMAVYMPFSLDPFELKDLGGADISLSGEYALFPIIDVGTTISHIPFVPATLSNGQTLTFSNDIIPETTNLLSDFPDIGDIDPDTSSFTDANKIVLRPLRVDFYVLYRPLRRDLLTIKPNIGFTAINPSEETYFNGAIELQLNLARIFFVHLNTGIEEGYWRHKLGFALNLHAFELDLEGVLKSQDYLKSYQASGLGVTLGMKVGF
>NC_015578.1|WP_041611340.1|250816_251935_+|S-methyl-5-thioribose-1-phosphate-isomerase
MNVNGKHYRTIWLKEEDKRVVQIINQLVLPHKFEILDLHRVEDVRRAIKDMYVRGAGLIGAAAAYGMYLAALEASDSAFERDLLASAQILKATRPTASNLAWAVDAMLAKLTGPSGDMEQKRVEARSLAGEIADQDAEYCRNIGLHGAEIIAGIAEKKKGETVNILTHCNAGWLAFVDYGSALSPVYTAFDRGIKVHVWVDETRPRNQGASLTAWELAQHGVSHDLIPDNAGGHLMQHGMVDMVITGADRVTRCGDAANKIGTYLKAVAAKENGVPFYVALPSSTFDFTMRDGLREIPIEERDAAEVRYVSGKTSGGIIETVQICPDATPARNWGFDVTPGRYIRALISERGVCEASERGILSLYPERAANG
>NC_015578.1|WP_015706421.1|251927_252545_+|class-II-aldolase/adducin-family-protein
MVKDGYVKYRAIHTPAGATESPLWAQLNEARTRLHDLGLVGEYPGGPGYGNVSVRLGENDFLISGTATGEKRVLTINEYSWVSSFDIEKNTVTTKGPVQASSESMTHGAVYRAFPGAVSVLHIHSRKIFDGMLRDGYPSTPAGAAYGTPEIALAISDCVARLGKPSGVIVMAGHDEGVIAWGPGIDKALDLVLELCTKYKLDAKN

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Crispr_ID: NC_015578_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015578_3

695370-695453

Orphan

Consensus_repeat	Method
AAGGTAAAAACTCCATTGTAAAAAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015578_3

>merge|NC_015578|3|695370-695453|CRISPRCasFinder
AAGGTAAAAACTCCATTGTAAAAATAAACGTAGTTCAATAAATCTTCTGGAATTTTTTTAAGGTAAAAACTCCATTATAAAAAT

>NC_015578|3|3|695370-695453|CRISPRCasFinder
AAGGTAAAAACTCCATTGTAAAAAT	AAACGTAGTTCAATAAATCTTCTGGAATTTTTTT
AAGGTAAAAACTCCATTATAAAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_015578.1\|WP_015706831.1\|704192_705353_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|224370
NC_015578.1\|WP_015706825.1\|693866_695330_-\|glutamate-synthase-subunit-beta	unknown	unknown	gnl\|CDD\|237213
NC_015578.1\|WP_015706827.1\|700783_702349_-\|hydroxylamine-reductase	unknown	unknown	gnl\|CDD\|235391
NC_015578.1\|WP_015706830.1\|703843_704167_-\|nucleotidyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|143393
NC_015578.1\|WP_015706824.1\|692148_693768_-\|murein-biosynthesis-integral-membrane-protein-MurJ	unknown	unknown	gnl\|CDD\|240528
NC_015578.1\|WP_148257395.1\|687877_690157_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015706816.1\|685196_685454_+\|type-II-toxin-antitoxin-system-MqsA-family-antitoxin	unknown	unknown	gnl\|CDD\|240606
NC_015578.1\|WP_015706835.1\|709136_709496_-\|ribosome-silencing-factor	unknown	unknown	gnl\|CDD\|376779
NC_015578.1\|WP_015706819.1\|686214_687849_+\|Ig-like-domain-containing-protein	unknown	unknown	unknown
NC_015578.1\|WP_015706829.1\|703410_703854_-\|HEPN-domain-containing-protein	unknown	unknown	gnl\|CDD\|368314
NC_015578.1\|WP_015706822.1\|690425_690602_-\|type-II-toxin-antitoxin-system-HicB-family-antitoxin	unknown	unknown	gnl\|CDD\|224514
NC_015578.1\|WP_015706834.1\|708811_709105_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368199
NC_015578.1\|WP_169313402.1\|685479_685806_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|376540
NC_015578.1\|WP_015706826.1\|695470_700210_-\|glutamate-synthase-large-subunit	unknown	unknown	gnl\|CDD\|236968
NC_015578.1\|WP_015706818.1\|685936_686149_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015706823.1\|690793_692044_+\|tyrosine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235645
NC_015578.1\|WP_015706832.1\|705392_706082_-\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015706828.1\|702581_703439_-\|DNA-adenine-methylase	unknown	unknown	gnl\|CDD\|273146
NC_015578.1\|WP_015706821.1\|690255_690429_-\|type-II-toxin-antitoxin-system-HicA-family-toxin	unknown	unknown	gnl\|CDD\|377942
NC_015578.1\|WP_015706833.1\|706160_707738_-\|sodium/proline-symporter-PutP	unknown	unknown	gnl\|CDD\|271369

Protein	Function_ID	Function_description	E-value
NC_015578.1\|WP_015706831.1\|704192_705353_-\|aldo/keto-reductase	gnl\|CDD\|224370	COG1453, COG1453, Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only].	4.98454e-135
NC_015578.1\|WP_015706825.1\|693866_695330_-\|glutamate-synthase-subunit-beta	gnl\|CDD\|237213	PRK12810, gltD, glutamate synthase subunit beta; Reviewed.	0
NC_015578.1\|WP_015706830.1\|703843_704167_-\|nucleotidyltransferase-domain-containing-protein	gnl\|CDD\|143393	cd05403, NT_KNTase_like, Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins. S. aureus KNTase is a plasmid encoded enzyme which confers resistance to a wide range of aminoglycoside antibiotics which have a 4'- or 4''-hydroxyl group in the equatorial position, such as kanamycin A. This enzyme transfers a nucleoside monophosphate group from a nucleotide (ATP,GTP, or UTP) to the 4'-hydroxyl group of kanamycin A. This enzyme is a homodimer, having two NT active sites. The nucleotide and antibiotic binding sites of each active site include residues from each monomer. Included in this subgroup is Escherichia coli AadA5 which confers resistance to the antibiotic spectinomycin and is a putative aminoglycoside-3'-adenylyltransferase. It is part of the aadA5 cassette of a class 1 integron. This subgroup also includes Haemophilus influenzae HI0073 which forms a 2:2 heterotetramer with an unrelated protein HI0074. Structurally HI0074 is related to the substrate-binding domain of S. aureus KNTase. The genes encoding HI0073 and HI0074 form an operon. Little is known about the substrate specificity or function of two-component NTs. The characterized members of this subgroup may not be representive of the function of this subgroup. This subgroup belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, co-ordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are conserved in this subgroup.	7.26969e-09
NC_015578.1\|WP_015706824.1\|692148_693768_-\|murein-biosynthesis-integral-membrane-protein-MurJ	gnl\|CDD\|240528	cd13123, MATE_MurJ_like, MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	1.33429e-119
NC_015578.1\|WP_015706816.1\|685196_685454_+\|type-II-toxin-antitoxin-system-MqsA-family-antitoxin	gnl\|CDD\|240606	cd12870, MqsA, antitoxin MqsA for MqsR toxin. This family includes domains similar to the antitoxin MqsA that binds motility quorum-sensing regulator MqsR, a toxin that is highly upregulated in persisters (dormant cells found in biofilms that are a source of antibiotic resistance), thus forming a unique toxin:antitoxin (TA) pair. MqsA neutralizes MsqR toxicity. It binds its own promoter as well as those of genes important for E. coli physiology, such as mcbR and spy. It also binds zinc and has been shown to coordinate DNA via its C-terminal domain. This family also includes the B. subtilis YokU protein, which is functionally uncharacterized.	2.3873e-11
NC_015578.1\|WP_015706835.1\|709136_709496_-\|ribosome-silencing-factor	gnl\|CDD\|376779	pfam02410, RsfS, Ribosomal silencing factor during starvation. This family is expressed by almost all bacterial and eukaryotic genomes but not by archaea. Its function is to down-regulate protein synthesis under conditions of nutrient shortage, and it does this by binding to protein L14 of the large ribosomal subunit, thus acting as a ribosomal silencing factor (RsfS) by blocking the joining of the ribosomal subunits. This family is structurally homologous to nucleotidyltransferases.	2.90471e-32
NC_015578.1\|WP_015706829.1\|703410_703854_-\|HEPN-domain-containing-protein	gnl\|CDD\|368314	pfam05168, HEPN, HEPN domain.	6.63434e-13
NC_015578.1\|WP_015706822.1\|690425_690602_-\|type-II-toxin-antitoxin-system-HicB-family-antitoxin	gnl\|CDD\|224514	COG1598, COG1598, Predicted nuclease of the RNAse H fold, HicB family [General function prediction only].	9.54344e-06
NC_015578.1\|WP_015706834.1\|708811_709105_+\|hypothetical-protein	gnl\|CDD\|368199	pfam04931, DNA_pol_phi, DNA polymerase phi. This family includes the fifth essential DNA polymerase in yeast EC:2.7.7.7. Pol5p is localized exclusively to the nucleolus and binds near or at the enhancer region of rRNA-encoding DNA repeating units.	8.52314e-11
NC_015578.1\|WP_169313402.1\|685479_685806_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|376540	pfam01381, HTH_3, Helix-turn-helix. This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within Neisseria gonorrhoeae NGO_0477, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteristic of the whole family.	4.79455e-06
NC_015578.1\|WP_015706826.1\|695470_700210_-\|glutamate-synthase-large-subunit	gnl\|CDD\|236968	PRK11750, gltB, glutamate synthase subunit alpha; Provisional.	0
NC_015578.1\|WP_015706827.1\|700783_702349_-\|hydroxylamine-reductase	gnl\|CDD\|235391	PRK05290, PRK05290, hybrid cluster protein; Provisional.	0
NC_015578.1\|WP_015706823.1\|690793_692044_+\|tyrosine--tRNA-ligase	gnl\|CDD\|235645	PRK05912, PRK05912, tyrosyl-tRNA synthetase; Validated.	0
NC_015578.1\|WP_015706828.1\|702581_703439_-\|DNA-adenine-methylase	gnl\|CDD\|273146	TIGR00571, DNA_adenine_methylase, DNA adenine methylase (dam). All proteins in this family for which functions are known are DNA-adenine methyltransferases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). The DNA adenine methylase (dam) of E. coli and related species is instrumental in distinguishing the newly synthesized strand during DNA replication for methylation-directed mismatch repair. This family includes several phage methylases and a number of different restriction enzyme chromosomal site-specific modification systems. [DNA metabolism, DNA replication, recombination, and repair].	1.7985e-87
NC_015578.1\|WP_015706821.1\|690255_690429_-\|type-II-toxin-antitoxin-system-HicA-family-toxin	gnl\|CDD\|377942	pfam07927, HicA_toxin, HicA toxin of bacterial toxin-antitoxin,. HicA_toxin is a bacterial family of toxins that act as mRNA interferases. The antitoxin that neutralizes this is family HicB, pfam15919.	2.33259e-07
NC_015578.1\|WP_015706833.1\|706160_707738_-\|sodium/proline-symporter-PutP	gnl\|CDD\|271369	cd11475, SLC5sbd_PutP, Na(+)/proline cotransporter PutP and related proteins; solute binding domain. Escherichia coli PutP catalyzes the Na+-coupled uptake of proline with a stoichiometry of 1:1. The putP gene is part of the put operon; this operon in addition encodes a proline dehydrogenase, allowing the use of proline as a source of nitrogen and/or carbon. This subfamily also includes the Bacillus subtilis Na+/proline cotransporter (OpuE) which has an osmoprotective instead of catabolic role. Expression of the opuE gene is under osmotic control and different sigma factors contribute to its regulation; it is also a putative CcpA-activated gene. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.	2.0988e-177

>NC_015578.1|WP_015706825.1|693866_695330_-|glutamate-synthase-subunit-beta
MGDPKGFLKIKRKVSGYRPVEERVNDYSEVEILLSDDERRQQAARCMDCGVPFCHWACPVSNVMPEWQDRLYRNDWAGAWAALEYINPFPEFTGRVCPALCEASCVLGANDEPVTIRQNELAIIEKAYDLGLVVPRPPRMRNGKKVAVVGAGPAGLSAAYFLNRAGFSVTVYEGAQKLGGYLRYGIPDFKLDKSFIDRRVSIMEAEGVEFRTGARIGSARYGFGAKGADGEGGEGKLISAKELESSYDLVLLTIGAREPRDVKLPGRENSGIVQALDFLSLQNRILGGENTGLEPITAYGKRVVVIGGGDTGSDCVGTANRQGAMRVTQIEVLPKPPEHRSDAEPWPLWPKVLKTSSSHLEGGERLWSVNTKAFVGRNNKVEAIQACRVDWAEKDGRQVMTEVPGSDFEIGADLVLLAMGFTHVVQNGAVADFELELDERGNIRTKGSFHTSNPKVWAAGDSRNGASLVVRAIDDGKAAAEAIIKTL
>NC_015578.1|WP_015706824.1|692148_693768_-|murein-biosynthesis-integral-membrane-protein-MurJ
MPMPSSARSLLRHGSALSLLTLGSRILGLLREMAKASLLGTSALSDAFSVAFMIPNLFRRLFAEGSIAVAFIPTFKEYLLASGNGDGGVEAAGHAQIREFLSCIFTFLTFFVTLAVIAGILVTPLVVSVFGMEEYNETVFLTRLMFPFLAFISLAAFFQGILNSVRIFAPSGLAPILLNLVTILCAYGLSRFTANPARAMAIGILAGGVLEAAIQLPFVLQKGFRFFFTGLKRAFKHPGTRKVLKLIGPTIIGMAAYQLNDLVSTALAGNAGAGVVSSLQYSLRLQELILGVFAVSLGTVLLPDLAEYAKSAQWALYNDRLISAMNIIALITIPITFFSLAQGETLIRLLFQSRSFNEQSVALTMSAFSFHMPGLFFIALNRILAPAFYAQSDSKSPTLAGIISFGVNIALATLLVGPFRGAGIALALSLASAVNTVLLLVFLRRNPYITLGKTLRSALLYAAKLILFSCIAALPVLALSPQLPSFTGHGRILAYGAPLAINAALFGAVGLLLLTLTGDPHLGAVVALLRQKRGKKDEG
>NC_015578.1|WP_015706823.1|690793_692044_+|tyrosine--tRNA-ligase
MNQALENLKTRGLFQQCTDPDALSRLMDAGPVTFYVGCDPTGPSLHIGHMVPFFAFRHLMAAGHKGIALIGGGTARIGDPSGKTEMRKMLSYEQLDANAACIAAQLDKFLGFDGDRARTANNKDWLADLNYIDFLREIGSHFSVNRMLSFEAYKMRMETGLSFIEFNYQLLQSYDFLELYRRHGNRLQIGGDDQWGNIVAGADLIRRIEGAEVFGMTFPLVTTADGKKMGKTEKGAIFLDPAITSPYEFFQYWRNVQDADLRRFLLMFTFLPVGEIDTITAPGKNPNEGKERLAWEVTALIHGNDEADKALSGAKAAFGGEGGDKSAMPSAALSLAKFQAGYNVVDLFTDAGLTPTKSEARRLVQQGGAFVSASGDTASLAAITDVAALIGADALDGDGELVLRAGKKRFCRVTTR
>NC_015578.1|WP_015706822.1|690425_690602_-|type-II-toxin-antitoxin-system-HicB-family-antitoxin
MEKQYTYWQEDGWYIGYFDDFPDHPTQGQTLEELEDMLKDLYDCLELSKYHKAKLFIA
>NC_015578.1|WP_015706821.1|690255_690429_-|type-II-toxin-antitoxin-system-HicA-family-toxin
MKRVDLISAISKNGAQFVRHGGGHDVYRQPKTGKQSAVPRHNEIKEYVARSIIRNLS
>NC_015578.1|WP_148257395.1|687877_690157_+|hypothetical-protein
MMNIWTLKHRVGAFAALALAISLVLGCESPVNAPVVVSQGVLVQIDQGILARTLLPNGDGLYYTLVFTADGKTPVNAVLDSGVSKPISLSAGPWALTVKGYLSKADAELIPAVTPVVSGNVPTVEVKPGEIVPVIVKLRPTQTSGKKGTLNYKVTFPNSPAVTIADLTVQKFGASSTSVTVDLLSNTTAPNTIIGAVSSASRTASGVIELDSGYYEVLITLNNGTVFQDGDIAHIYDNLETPAIFTYTDTGTGSRFAKADYSAEGVYVGIISFAGTATDLFDGNLIFLDAAGTTTLTNALKYQYNIASQSGTALFYSVHKAIANLKSNEALYPTNLESVNLITFTDGLDNGSFLQSNSAPLEGQKQMESGPYAAYIGNQITSRTIRGKPITAYSAGVKGGDVEDIGKFTSDLSALASPGKSFKLANYEQLTDQFKKIAEGLNITNTDTTFTMVTTGNDPDTKIRMTFDSIGIDSSAASGSTKYFEGTLTYTAGDPYLTNITYADGFGSTEGDGPIPGTINGSEINFVLTNFQGYNRANAINVKQWTKKKADTLWQRNSEYSVGSAVAYTFDRRSAIIYLVLDASTSLASNTSDYIPDIRNAAIRFIEDIYSQYHEGEISDIYSPKTPTSITEPWILQADGRYKSPAILDDEKTIMRIDFSTIGATTVQIQLDVSSELDGDYALVSGLYLIASGPRESNYSWSSLSALSITEYQYRISGNASQTIAIPVTSAGHYFIDIGYEKNSSGTAGEDRAWFKIEN
>NC_015578.1|WP_015706819.1|686214_687849_+|Ig-like-domain-containing-protein
MKKRFGAAILGKAALAAMLIFVMAFVSCGDLFGPDDDDNNNNFNPYNPTYSSPPINDIDASLVGTWRDNVQDGAILNVSFQSSGTAVIWGGSTGSWLNDPTLVYQGGTWGAKDGKISYQYTSTLQTVDVYSYSINNIGQLVLTASGMTIVLNKSSFVGVSYINYLPTSVVMGTPLTLSGTVSPYNATDRTIVWSISDADGTGAVITNGNILTASKMGNVSITATITNGKEDSYSYGYGYTYYYSIGSYTQSFTITITSDFVPVTSISDVPSSAVEGVPLVLTGTVYPDNATNQTIEWSVDSYYGTIIDGIFTPTISGNNAYITATITNGGWSASSDYSTSIYIYVSSMTPVTAITGVPTSATAGTPLTLSGTVSPAEATWQTIVWSVANAGTTGAAIINGNSLTTTAGGTAIVRATITDGTKGYFSGSYSITDYTQDFTITVIPTNSISLSFTDESGAAFTQGGFTISKGNAMNYTKTIILVGDWDSQKWRVDSGDSIIVGSSTSDKVTVNAADYALGAHTLSVRVVKNNVPWTKNITFTVVTD
>NC_015578.1|WP_015706818.1|685936_686149_+|hypothetical-protein
METGEISDFPLETYRQLPYESKQFLKSIYRNLVLLQNSIAPKEPGQKKGVAARGTCRLKSVQAASGHREE
>NC_015578.1|WP_169313402.1|685479_685806_-|helix-turn-helix-domain-containing-protein
MRKKLNLSQLDFGKEISVSRSQVALLEKSRRTVNDRHIRLISSTFSVNPVWLRAGEGNMFITQEDVETRQKDEKEIIDFYNQLIPEVRVFARNVLKNLADLNGKILKK
>NC_015578.1|WP_015706816.1|685196_685454_+|type-II-toxin-antitoxin-system-MqsA-family-antitoxin
MTCGICKAETEQKLVTYTEDVNNSVIVIRNVPATVCTECGNVWYSGTVAAQLEAIVDHCLKGIVARGTLLQVADVAVVNYAEQVA
>NC_015578.1|WP_015706826.1|695470_700210_-|glutamate-synthase-large-subunit
MGQHEEEVDQRLQKGLYREEDEHDSCGIGFVADIKGRPSHEILKRGLEVLERMEHRGAESADNKTGDGSGVLIQIPHDFYKKFVPALPEAGNYGTGLVFLPGPAGDKKAEEKGAKILGLIDETAATAGLSVLGWRDVPTDTGVLGAIAQAAEPLTRQIFLGSQDQGAKRDGEGVSDLEFRLYIFRKSLEKRIREDPALENAGARGYMPSLSSRTIVYKGMLMSSQLQNYFPELKDEGLKTAVALVHSRFSTNTFPNWPLAQPFRIVSHNGEINTVKGNRFWMAAREALFAHPRFGAALKDLFPLIEPDQSDSASFDNVLELLIMSGRTLPHALMMLIPESWNDKNPIPQELKAFYEYHAAIMEPWDGPASMVFCDGRFVGGTLDRNGLRPSRYTITKDDLIVMASETGVQDFSPKEVVYKGRLRPGKLLMVDLLEGRIIPDDEVKRQVYQSKPYGDWVKRQIITLQQELTGEGQGVKFVDPQLKSDAKRLYMERVAGYSREDREKLLLVMAETSQEPTGSMGTDTPTAVFSDRSQRIYTYFKQVFAQVTNPPIDSIREDLVMTLTSFIGPQKNLLEETESHCRRIKVLNPIMTPADLETLKQVHPVDFKSRILDATFEVKNSELETGKVSRQLLKPALDNLIAEAIKAVKDGVSLLILSDRGALSPEAVPSGAAKTGRCAIPALLAVGAVHHGLIRAGQRMHLSIISESMEPREPMHFALLFGYGADLVVPYGALASLAAISAGPDGKRAGSFPEAKKHYIKGLNKAMLKVMSKMGTSTLRSYRGSQIFEAIGLGPEVIDTCFRGTPSRIGGAGFAELEGEVLDHYREARKAFIKTGDWPQGVDYLLNGDGQYRWRKFGEKHAWNPESIYLLQWATRTGDYKKFKEFSTLTNKLNQSPHVIRGLLDFAAPGTVKDGPAAPVPLEEVESVETLMRRFTTGAMSFGSISREAHETVARAMNSIHGRSNSGEGGESPERFAVRSDGSWLRSAIKQVASARFGVTSEYLANAEEIQIKIAQGAKPGEGGQLPGHKVDAMIAKVRHSTAGVTLISPPPHHDIYSIEDLAELIFDLKNANPQARISVKLVSESGVGTVAAGVAKAHADNILISGYDGGTGASPQSSIRHAGLPWELGLSETNQVLVKNGLRGRVRLMTDGQLKTGRDVVIAGMLGAEEFGFGTSTLINMGCVMMRKCHENTCPMGVATQDPELRKRFTGKPEYLINFFRFIAEEVREIMASVGIRKFDDLVGRADLLVERKSGKAKSAGVDLSALLYKPEGPAFIPGGQERRCVQDQVHNIGKVLDRQLIEKCFSALDKKIPAALSLPVRNTDRAVGAMLSYEVSKRFGGQGLPENFVTVDFTGSAGQSFGAFLAKGITFRLAGDSNDYLGKGLSGGRIVVAPPPGSTFETSENIIIGNTVLYGATSGELYAAGVAGERFCVRNSGATAVVEGAGDHAAEYMTGGRLIVLGTVGRNFGAGMSGGIAYVLDRKGDFEYFLNKGMVELSGLDNEEDESFVKQHIEQHIYWTGSAYAKNILDNWAEYKPKFVKVLPVEYKMALQQMKLAELDRKLYDIREREEISERV
>NC_015578.1|WP_015706827.1|700783_702349_-|hydroxylamine-reductase
MFCFQCEQTAAGKGCAGKAGVCGKKDDTALLQDQLTGALIILAKVASRKGKTKNTDRIIVEGLFTTMTNVDFDNAAIAKKIEIARAERAAIFAEAAQCEDFDMEKIWQAHEDIRSLKSLLLFGVRGIAAYAYHGMVLGYTDQTVTDFFYTALNALSEEQYGMDELLPLVMETGKINLKCMEILDKANTESYGHPAPAKVSLTVEKGPFIVISGHDLRDLKLLLDQTRDKGINIYTHGEMLPAHAYPALRAYPQLKGNFGTAWQNQQQEFDGLPGPILFTTNCLMPVKDSYSDRVFTTGEVAYPGMVYIGEPKDFSAVINKALELGGYKEDHPMTGINGGKEVTTGFARNTVLAAAETVVNAVKAGAIKHFFLVGGCDGAKTGRNYYTDFVKQSPKDSIILTLACGKYRFNDLDIGEIGGLPRIMDMGQCNDAYSAIQVAIALADAFKCGVNDLPLTMVLSWYEQKAVSILLTLLYLGIQNIYLGPSLPAFVSPTVLNFLVEKFAITPISTPEADLAKILAK
>NC_015578.1|WP_015706828.1|702581_703439_-|DNA-adenine-methylase
MNKDEKITLKPYLKWAGGKRQLLAEIKNHLPGNIDKYTYYEPFIGAGALFFELQPKRAIINDFNAQLILTYRAIKENIEQLIELLRTHRENNDKEYYYKIRNLDRNTDEFNKLTDTEKAARLIFLNKTCFNGLYRVNSQGLFNVPHGKNKNPAIYDETLLRQIGNYLNSNDITILNTDFEQAVTNADTNSFIYFDPPYHRLDKTSFTGYQADGFLETEQERLRNVMITMAERGVKCLLSNSDTEFIRGLYAHGYFEIIPVSARRLINADSGGRGAVNEVLIKNWK
>NC_015578.1|WP_015706829.1|703410_703854_-|HEPN-domain-containing-protein
MNLKDTIQWFYKAAEDYDAAKILNSALKKHNEIICYLCSQATEKYLKGYLVYNDHEIENTHNLPYLNNLCLQYDNCFNDIKDECSLLNKFNNNIRYPDGIEANSNDVNLSFKALENIINLEALKKLEQIIQNQNTEKVFEQRRKNNP
>NC_015578.1|WP_015706830.1|703843_704167_-|nucleotidyltransferase-domain-containing-protein
MKINFDKDIQLIKETILNNIDAKSIYLFGSYAYGKPNEDSDIDIYTVLPDKYKNTTEIYAKIIRELSDKNIFFIDLLLVNENIFNSRKNDYILENTIYNKGKIIYES
>NC_015578.1|WP_015706831.1|704192_705353_-|aldo/keto-reductase
MQYREDKVSGNKLSILGLGCMRFSRNMAETERMILAAIDGGVNYFDTAYIYPNSEETLGTILGKHKKRTSVFIATKLPLIVCKGPDDFDKFFNKELERLQTDYIDYYLMHMITDSAQWEQFREWGIEQWIAEKKRAGKIRQAGFSFHGSSVEFLKILNAYPWDFCQIQYNYSNENYQAGKEGLKAAAAKGIPVMIMEPLLGGKLAAGLPKEAAALFSKTDPTLSPAAWGFRWLWNQSEVSCVLSGMNTTAQMEDNLRSAENARPLTDAELAVYTEVIGLFNRAYKIHCTGCNYCMPCPKGINIPGCFAAYNASFAQNFTIGMQQFLTSTAAVSKKPHSPRLCVECGKCESHCPQHLPIRKALKQVARRMEPLPVRLGLSIARQFLG
>NC_015578.1|WP_015706832.1|705392_706082_-|hypothetical-protein
MTRGILIAGNESTLSAAIASETGRRVDRFVAAIIPNRLPYPLENRPASAKAPEGTGPIPLDWNPGSPVSARTMVLGAENRLGQLSEAILVCTPPAVRKSAENLNPANLEIIINDYIKGWFFLVKELATVFKAHGAGALALVLADIGSGGGRDDPVDLIGPPVAASFRAFAQGLMDSSRNEPYQVYGFSASEAGEDNALGTFIFNIIEEGNKRDSGKWHKFGGKLSFLGR
>NC_015578.1|WP_015706833.1|706160_707738_-|sodium/proline-symporter-PutP
MSASNIQTLIGMGAYLVVMIVIGLWYAQRSNSNPEEFFLGKRGLGPWVAAMSAEASDMSGWLLMGLPGVAYFTGMGEAFWTALGLFIGTWINWQLVAKRLRAYSQVADNAITLPTFFSNRFHDKKRILMSIAALVILVFFSIYAGSQFVTFGKLFGYVFGAEDYYTAMVILGAALVMVYTLLGGFLAESTTDFIQGLMMILVLILVLGFGVSHAGGLAGVSENLKNFPRFTDIFGIATPLDASGKAAGVQALVNGKPSFGPGANYSLLNIVSCMAWGLGYFGMPQVLLRFMAIRKSSKIAQSRLIAVTWCFVSLFAAVAIGLIGRAYMPALLNTAGNSETIFIHLAVDFFPPLLAGLVISGVLAASMSSSDSYMLIASSALANDIFKGLVKKDASESLVMWVARITMLLVTIFGVAIALSGNQSIFRIVSYAWAGLGAAFGPLILFSLFWKRTTLQGAIAGMLTGGGMVIIWKEFISKIGGAFGVYELLPAFILSCLAIFLVSLATPKPSEEIEKEFIAAKTAEF
>NC_015578.1|WP_015706834.1|708811_709105_+|hypothetical-protein
MVLFETMYTEELMLIPLVNEHNAGYPPFLALDDDDDDDEDDEMEEEEEFDDIEEEFDDDFDDDFDDDDDDFDDDDDDDDDNFDDYEEDMDFDDDFDD
>NC_015578.1|WP_015706835.1|709136_709496_-|ribosome-silencing-factor
MEDTFQVDKTAALELAALIRDHRGEDVIVMDLREINHWTDFFVVATVSSSAHVQGLQRHIKDYARDKGIEILRQHRKASSDDEWNLIDLGNIVVHLMSSGSRSFYELERLWSAAVIVSP

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Crispr_ID: NC_015578_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015578_4

745131-745228

Orphan

Consensus_repeat	Method
GGGACCTTCACCATGAGCGGGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015578_4

>merge|NC_015578|4|745131-745228|CRISPRCasFinder
GGGACCTTCACCATGAGCGGGGGAACCATTAGCGGGAATATCGCCTACTGGGGCAGTGGGGTGTCTCTTGATAGCGGGACCTTCACCATGACCGGGGG

>NC_015578|4|4|745131-745228|CRISPRCasFinder
GGGACCTTCACCATGAGCGGGGG	AACCATTAGCGGGAATATCGCCTACTGGGGCAGTGGGGTGTCTCTTGATAGC
GGGACCTTCACCATGACCGGGGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_015578.1\|WP_041610991.1\|748479_751584_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377406
NC_015578.1\|WP_015706873.1\|746630_748520_+\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|143636
NC_015578.1\|WP_041610990.1\|739602_743517_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015706877.1\|753508_756088_+\|LuxR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225461
NC_015578.1\|WP_015706867.1\|735516_735852_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|225495
NC_015578.1\|WP_015706878.1\|756144_758619_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225461
NC_015578.1\|WP_015706883.1\|765755_767576_+\|elongation-factor-4	unknown	unknown	gnl\|CDD\|235462
NC_015578.1\|WP_015706881.1\|761942_762581_+\|cobalamin-binding-protein	unknown	unknown	gnl\|CDD\|239021
NC_015578.1\|WP_015706876.1\|752751_753087_-\|MGMT-family-protein	unknown	unknown	gnl\|CDD\|226219
NC_015578.1\|WP_015706875.1\|751573_752755_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015706866.1\|734930_735464_+\|2-oxoacid:acceptor-oxidoreductase-family-protein	unknown	unknown	gnl\|CDD\|376567
NC_015578.1\|WP_015706870.1\|737245_738193_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015706863.1\|732797_733028_+\|ferredoxin-family-protein	unknown	unknown	gnl\|CDD\|224069
NC_015578.1\|WP_015706868.1\|735848_736199_-\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl\|CDD\|368831
NC_015578.1\|WP_015706879.1\|758819_760298_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|225117
NC_015578.1\|WP_015706865.1\|734151_734931_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|239470
NC_015578.1\|WP_015706869.1\|736397_737135_-\|deoxyribose-phosphate-aldolase	unknown	unknown	gnl\|CDD\|234784
NC_015578.1\|WP_015706882.1\|762652_765697_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015706864.1\|733024_734155_+\|3-methyl-2-oxobutanoate-dehydrogenase-subunit-VorB	unknown	unknown	gnl\|CDD\|235942
NC_015578.1\|WP_015706871.1\|738320_739589_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_015578.1\|WP_041610991.1\|748479_751584_+\|hypothetical-protein	gnl\|CDD\|377406	pfam04773, FecR, FecR protein. FecR is involved in regulation of iron dicitrate transport. In the absence of citrate FecR inactivates FecI. FecR is probably a sensor that recognizes iron dicitrate in the periplasm.	0.00216359
NC_015578.1\|WP_015706873.1\|746630_748520_+\|HAMP-domain-containing-protein	gnl\|CDD\|143636	cd07302, CHD, cyclase homology domain. Catalytic domains of the mononucleotidyl cyclases (MNC's), also called cyclase homology domains (CHDs), are part of the class III nucleotidyl cyclases. This class includes eukaryotic and prokaryotic adenylate cyclases (AC's) and guanylate cyclases (GC's). They seem to share a common catalytic mechanism in their requirement for two magnesium ions to bind the polyphosphate moiety of the nucleotide.	4.86262e-56
NC_015578.1\|WP_015706883.1\|765755_767576_+\|elongation-factor-4	gnl\|CDD\|235462	PRK05433, PRK05433, GTP-binding protein LepA; Provisional.	0
NC_015578.1\|WP_015706877.1\|753508_756088_+\|LuxR-family-transcriptional-regulator	gnl\|CDD\|225461	COG2909, MalT, ATP-dependent transcriptional regulator [Transcription].	5.79938e-38
NC_015578.1\|WP_015706867.1\|735516_735852_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|225495	COG2944, COG2944, Predicted transcriptional regulator [Transcription].	3.01918e-11
NC_015578.1\|WP_015706878.1\|756144_758619_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|225461	COG2909, MalT, ATP-dependent transcriptional regulator [Transcription].	2.03062e-24
NC_015578.1\|WP_015706876.1\|752751_753087_-\|MGMT-family-protein	gnl\|CDD\|226219	COG3695, COG3695, Predicted methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair].	1.17197e-30
NC_015578.1\|WP_015706866.1\|734930_735464_+\|2-oxoacid:acceptor-oxidoreductase-family-protein	gnl\|CDD\|376567	pfam01558, POR, Pyruvate ferredoxin/flavodoxin oxidoreductase. This family includes a region of the large protein pyruvate-flavodoxin oxidoreductase and the whole pyruvate ferredoxin oxidoreductase gamma subunit protein. It is not known whether the gamma subunit has a catalytic or regulatory role. Pyruvate oxidoreductase (POR) catalyzes the final step in the fermentation of carbohydrates in anaerobic microorganisms. This involves the oxidative decarboxylation of pyruvate with the participation of thiamine followed by the transfer of an acetyl moiety to coenzyme A for the synthesis of acetyl-CoA. The family also includes pyruvate flavodoxin oxidoreductase as encoded by the nifJ gene in cyanobacterium which is required for growth on molecular nitrogen when iron is limited.	1.40381e-39
NC_015578.1\|WP_015706863.1\|732797_733028_+\|ferredoxin-family-protein	gnl\|CDD\|224069	COG1146, COG1146, Ferredoxin [Energy production and conversion].	7.02144e-10
NC_015578.1\|WP_015706868.1\|735848_736199_-\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl\|CDD\|368831	pfam06296, RelE, RelE toxin of RelE / RelB toxin-antitoxin system. RelE is a family of Gram-negative bacterial antitoxins of the RelE/RelB toxin-antitoxin system. Its cognate antitoxin is family RelB, pfam04221.	1.40539e-10
NC_015578.1\|WP_015706879.1\|758819_760298_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	8.35329e-27
NC_015578.1\|WP_015706865.1\|734151_734931_+\|MFS-transporter	gnl\|CDD\|239470	cd03375, TPP_OGFOR, Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA. In the reductive tricarboxylic acid cycle found in the anaerobic autotroph Hydrogenobacter thermophilus, OGFOR catalyzes the reductive carboxylation of succinyl-CoA to produce 2-oxoglutarate. Thauera aromatica OGFOR has been shown to provide reduced ferredoxin to benzoyl-CoA reductase, a key enzyme in the anaerobic metabolism of aromatic compounds. OGFOR is dependent on TPP and a divalent metal cation for activity.	1.90961e-73
NC_015578.1\|WP_015706869.1\|736397_737135_-\|deoxyribose-phosphate-aldolase	gnl\|CDD\|234784	PRK00507, PRK00507, deoxyribose-phosphate aldolase; Provisional.	9.91786e-118
NC_015578.1\|WP_015706864.1\|733024_734155_+\|3-methyl-2-oxobutanoate-dehydrogenase-subunit-VorB	gnl\|CDD\|235942	PRK07119, PRK07119, 2-ketoisovalerate ferredoxin reductase; Validated.	0
NC_015578.1\|WP_015706881.1\|761942_762581_+\|cobalamin-binding-protein	gnl\|CDD\|239021	cd02070, corrinoid_protein_B12-BD, B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or monomethylamine, which is initiated by a series of corrinoid-dependent methyltransferases.	3.90651e-58

>NC_015578.1|WP_041610990.1|739602_743517_+|hypothetical-protein
MIGHTGLKKTSAALFLGCLIFSACSNMLESSNSPNSPNFSGYPGTYNPIPPGKGRVMVKIGDSSGARTLIPEDLPVFSKYELEFTAPGKDSFSLSISAPLDMAGLTGSGYPVDLDSAIWSLTVTAFVSYEGAYLQAANNTITLDVVDGALTLQTITVDSLPISQGGDGLFYWNLAVSDVSYTGTLTLAREGEGAALSKTFPGDTLTGTAAVAAGYYVMILELTNDANKTARRAEVVHIYPGLTTNGDFSFSGGDFVAQKYLEGTLSLSDFSGPVSAITVHAYSGAGFTQMLDSVLAVDTDGTWAWKAKVPVTHRDINFLAAITAGGKTYTLIVGTESSVGDAGRSGISLSAVYKTITAWAEIKEAIDRIPPAAAGFVPGGESVLVIGASFDIADSIVLNKPITLEADSSPRSITRGTGMTGAFFDIQSGGSLTLGETSTAVLTLDGNKGSVTAAAAMVTVNGGSLVMNDNALITNNSNNGVSVNTGSFTMSGSAQVAQNNPVYLAAGRTITLGGNLTQTTAAVIDLPASTALGAQVLEGSAYLIGNHSKFTIAGYDSDVRWVNSAGQLEFVKLLEGTLSLSAFSGGTASAITVKAYSAGFTELLYTDTAVNTGGTWTWEAKVPLTQNTIDFLATITAGGKTYTLIAGTATSSGDQAGISLAGVYTSITGWQDIKAVLDRIPPASTEGFTPADESVLVIGASFTATATSGTIVLNKAITLKADTTSDRSITRGTGMTGAFFDIQSGGSLTLGETSAVKLLTLDGNKGSVTAAAALITVNGGILIMNNNALITNNTNYGVSVNTGSFTMSGSALVAQNNPVYLAAGRTITLGGNLTQTTAAAIALPASTALGAQVLEGSAYLSGNHDKFTIDGYDSDVRWVNTAGQLEQLSLVLDGTLSLTDFSGGTVSAITVKAYSDSAFTSALDSVSAVNAGTWTWKVKVPVTQTSVDFLAIITADSKTYTLIVRTAFSVGGASQSGISLSAVYKPITTWMGLKEAIDRIPPGFTQGEESVLIVGGDVTTTTAPGTIVINKPITLKADSSNRTITRGTGMTGAFFDIQSGGSLTLSEASAVNLLTLDGNKGSVTATAALVAVNDGSLVMKDNALITNNTNNGVSVNTGSFTMSGSALVNQNNPVYLAVNQKITLGGDLTQTFAAAIALPTSTALGAQVLEGSSYLIGNHSKFTIAGYDPAVRYVDTNGQLAQREPSITCVIGYSQLSFSGAAVAVDRGATVSVTAQNATGLTLSGWTASGRDYRGARITLSNVTGATEGLTFTAPSAAGEYDITITVIVNGKIHSGNFRLRVRA
>NC_015578.1|WP_015706871.1|738320_739589_+|hypothetical-protein
MDIGNHGLRKMKQALALLPRGIALLWALLPLSGCEILNLSTEAFIELQTGRAESQSWEFISGGSISPSGTPIIAPGESYIEVNLQNYLNYDLMLNVVNQNALAQGRTLEAKSLGYNKVRIRIDGATLGDEFNFTLKMGTSDGLRNFNDFKLPMVVCNTPLWVSIPGAVDEAVKGTEIGTPPVAHWKMQAPDEHRGMQKLILEFQHENDGILTEEYDLIWDETAGEETAGDETTSDETTNDETTNDETTGIETTGAWALVGADASRNFGLRDGFYHINFPLSIRRNRLPVERHYFFRLRVRDVYGFIETASTPGFGEITEGPDTNQPIQVSFSGLPADESGVLSVPGTSGVLSWEKPLTLTITGYPAGAAFLWYIDGVPVTAGGTDASLSIPAGNFSLASHQVMVKMTLSGVVYSKSVSFRVE
>NC_015578.1|WP_015706870.1|737245_738193_+|hypothetical-protein
MIDKRFRSLFIPLLFFAALPLWGDSGIEHSAGLSLQTSTRPEAKLGFTWNLSVPLLQGEGPLTEGNNLNLALGADVSPISLNGSAEAVFTPIAFLQAVAGGRIGSGWNINLFGGDVYGMGINRRRAADLKPEVSGSAFNGLLWSAWGGGVFQFDLAALVPGDWSHVVFRTYHEARYKGDTAASSSDSWYYESDDGQNRNGFNYYGNYLLGYQMPIFLNTVGLMAEMDLYLYDTPKRGSWGDELPRWTFGPLFNFTVTEKFSAALIVQFRTRRNYTAGDEDDLGATVFYQDRRLKDSDPLYLTFYRAAAILSYKLW
>NC_015578.1|WP_015706869.1|736397_737135_-|deoxyribose-phosphate-aldolase
MGNETDKKNGGAGITTAGLAKFIDHTLLKPEADTAGIDKLCAEAKQYGFYSVCINSAYVARCAKTLAGSEVKVCVVVGFPLGAMGAEAKAFEAEYAVKNGADEIDMVMNIGAMKSGDLSLVEGDIAQVRKACAGNCVASSGKKALLKVIIETCLLTEAEIVSACTIALKAGADFVKTSTGFSTHGATVEHVALMRKTVGAAAGVKAAGGVRTYEDALAMIKAGATRLGTSGGIKIISGQTIDSGY
>NC_015578.1|WP_015706868.1|735848_736199_-|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MTRVFVSTVDFDKYWAALGLADDDLYALQNELLNDPASGDLIQQSGGARKIRVAARGHGKRGGARVIYVDILFHEKIYFLTAYPKDKKDDLTPAEKKAISILIKTLKTELKTGRNR
>NC_015578.1|WP_015706867.1|735516_735852_-|helix-turn-helix-domain-containing-protein
MNTDASVFDNFEAGKALIHSLEQAIAFERGDKTKARVSVREIPTPKYEAGDVIQIRQRYQLTQRALALALNVSPRTVEAWEAGKNKPSGSSSKLLYLLERDTTIINQLVSR
>NC_015578.1|WP_015706866.1|734930_735464_+|2-oxoacid:acceptor-oxidoreductase-family-protein
MTEKSFFAGFGGQGIISLGQIWAYCALKEGKNVTFFPFYGAEKRGGIARAGVVVSDEEIDSPLVTTPDSVLVMNADSLPLCEGNLKPGGLMLINSSLVKDAPKRSDIRLFTADLQALAEKIGHSRYTNMVALGAMAKLTGILNVEGIEPILKKFFPEDKHKFLPMNIAAIQAGFGAV
>NC_015578.1|WP_015706865.1|734151_734931_+|MFS-transporter
MKQLYGHPKSLYNVATKYCGGCGHGVIHRIITELIDEMGLRDRSIITNPVGCAIWSDLYFDFDSVQPPHGRTPAAATGIKRVLPDHLVICYQGDGDMAAIGTAEMIHAANRGEKFTTIFVNNAIYGMTGGQMAPTTLIGQKAATAPLGRDPDAAGMGYPIRVSELLAQLDGTRYIARGSVHSPGQVRKTKQYIRKALEAQLAGVGFTMVEVLSPCPTNWGMEPVPAMDWLEREMIPVFPLGEIKNTLDQVTPIRKEGVA
>NC_015578.1|WP_015706864.1|733024_734155_+|3-methyl-2-oxobutanoate-dehydrogenase-subunit-VorB
MSSEEVLMKGNEAIAEAAIRAGCTAYFGYPITPQSEITAYMAKNMLERDRIFIQAESEVAAINMVYGASCAGARAMTSSSSPGVSLKQEGMSYAAGADVPLVLVNVVRGGPGLGSIAPAQSDYFQSTRGGGHGDYRNIVLAPKSVQECADFTYQAFDLADKYRIPVIVLADGLIGQMMEGVLLPPERSLKDLPKRDWTAGHLPERTGKAGGDAVHITSIFLVPEELEARNKVRFARYAEIEKKELRFEAVGYKTACNEFTGEGPDLTLVAYGSSARIAQGAKKLAEKEGIKLGLFRPITLWPFPYQALGKVAATGKPLLTVEMSEGQLVQDVKLSVLEAPEGSKRAAVHLLGHSGGVIPTEEEVFARVKKILEGKA
>NC_015578.1|WP_015706863.1|732797_733028_+|ferredoxin-family-protein
MARKGKVVIDRELCKGCYLCIRACPSKVLEKDNKINSGGSYPSVPVRPEDCIACGNCYEMCPDVCIQVFELGEASA
>NC_015578.1|WP_015706873.1|746630_748520_+|HAMP-domain-containing-protein
MPRDAKKPGAARVKYPIGFKLVGIITILLLVSLGAITALVSVMVSSDLRVTAEENNFSVNKRSASEAETTLSTVRSSVLVLLDTLNAVGSSQAALSRQAAAFFFERNQDIAAIVITGDRELVNNRFFLANELESDLVGEFMTRQREAVDRSRSGETLLLNAAPIFHIPLLALLFPWQETGAEEVVLILFSSDSLNDNFGQGVNSSYMINDAGDILVHPDYELVRAGANVANQPFVETLRESQERNLQTLYTDRDGGRYFGAFQKLSVANAVVITNVEYDVVFEGIAATTRRNIYLTGAVLFVSIVLIWLFSKTISRPLKGLTVVAGQIEEGLFEQNLVSKSRDELGVLTQSFSRMSKALGIFGRFTNREIALGAMRGEIKPGGQPKHGTVFFSDIRNFTSISEEFARNYGDESSDRIVAWLNEYLTRMVECVEKTNGVVDKFIGDSVMAHWGTAYTSGSPEADALNGVRAALMMREALYQMNKNRGENDPANPRIRIGCGINSGVVTAGQIGSEQRMEYTVIGDAVNLASRTEALNKPLGTDILITEDTWNLAGEHLITEEMPSVEVKGKSQPVRMFAVVNFKADMAIEGQLQPQTLAELRDLLGIIPPDLSKVNTNAEEKKYKIGSGE
>NC_015578.1|WP_041610991.1|748479_751584_+|hypothetical-protein
MRKRKSIKSAPVNKAPGSRVFGAPDYAVFLICIAGAIFCLWFFQRDLNQSLTRLNEAPMGTITFKYKAAQRRFSDRVLWDRLAKESPVYNGDMIRTADLSEATVTFHSGGIINLQENSIIQLFEENAIPRIDFTLGSVSVNVHSGGGIILSSGNSRLEVLSGGVVSAGAGEDGFTASIVEGRAIVSGETLEAGSVFSGDPGGISLSRTVSLQPRPATRLLVNERRPSTVQFKWNKVNYTETTRFEVAEDRGFTRPAAQLDLDGDEALVELAPGTWWWRVYPSGMAEGLEGGAAENSIEKLAISYAPPPEQITPAEGYVYRYRTKQPSVRFQWTETAEAAFYIVTAADNPQLLNPALQIQEQGTSFIYSKLPPGRWYWQVQPVFSGDYEGTSAGSGLSYFSIEQSGDLSPPVLSNPQNGSSFNISAERQDFYFSWANNLEADSYTLRISRNRDLSGPIITRMVRDNYYVYRADDRTISDGQYYWGVYQTDMEGNASPVSSVNGFFALEGEVIQRTLFPPDNYTTAESLLPDTRFTWRSNLPFQTRFQISSTPDFSNPAIDEVTGGETIRGRQLAAGTWYWRIAVESPEVTLQTAPKVLKVAPPLGRPVMETPRDNALVAIPEQGDVPFQWAAVPDADYYQFRLYREADPTRPVYEDNLNAAESRVINWSNYAEGNYVWTVQALAEETPLRSRQNGLISSAAFSLRKLRPVTLESPEPGAVLNGLAAYRQGETIRWSAPETLGNSRFILSRNSDLLAGRPVMDITNPNPSIPLSQLREGTYYWTILGETPEGYDVSAPTPASFRVLPIEITPVSLNQPGNNTEFEGLEALRRPGRVRWSSDEIPQTSRFALSRNSDPLKDPLMDIRNPGAEIPLVRLEAGDYYWTIRAETPDSLDISAPAPFSFRVLPIPPLPSPEGVSPENGALLGPDQLAAMNSITFSWGTVPGANAYIFSLYREDETGLPEIARTEAQPVVSYTLPDLSALDVGTYIWQVEAVSLAEDGYIEQRGMIASNRLTIDIPLPSNPRRADMGILYGQ
>NC_015578.1|WP_015706875.1|751573_752755_+|hypothetical-protein
MGNKLIFAALLLLTLLPRFIAAQEKGEDETYSYVVLENGGAKIIQHLFWAAEPYVRQYEIIIGLKNVDESYTEILREFTKETFIDVSLGPGNYRYTIQVYDLLNRPQGIGEWEYFEIMLALKPGIQSFSPEAFYLDEDTSWNIVITGLNLVDGAEVLLRQTDRPRDIVPQTTVIDSAGRTVRISFAMSSLVTGNFTIFIKNPGGLETETGTFRVAFRKPVDFNVSAGYGAVIPLYGSFFSFFDQGAFPLGAHTKLSLVPFKRVWGYLGVELDPFWNYMDTKNPSEGYDVVSHLTGLNVNLLYQKWLSNRTMAFNLRLGAGVVSILDFHFAYSSGNSESFTGLYFSAGAGASFQWLIRKPFFVEAGVSFNHVFAANDQIQPGFIRPLIGAGWQF
>NC_015578.1|WP_015706876.1|752751_753087_-|MGMT-family-protein
MKKPLHDSTIRILAAIKAVPRGRVSCYRDIAFAAGMPNGARQVARILHSMSEGEKLPWHRIIRADGHIALPEGGGREIQISLLRAEGVKVSKAGVVDLGRYGTGASGQKAT
>NC_015578.1|WP_015706877.1|753508_756088_+|LuxR-family-transcriptional-regulator
MPDQLFYSNVPINSGNQIYLDRPQVHDLLEKAARSPIVTVTAGAGYGKTQAVYSFARKYNAVTAWIQFSERDNLGGRFWENYTRAVGFIDKETELKLRALEFPDTDQKFERYMRIPRNDIKPAQKYLFVYDDFHLIRDPGVLHFIERSITTPFSNITSILISRTEPRINSIPLLSKGYLAQINEDDLRFTAEETQEYFYLQQVDAPPDAAATVCRDTEGWAFAIHLAALAIKNEPSGKRYAPSSVKANIFKLIESEVVAVISEDLRKFLIKISLIEHLARDILLDIAGDAGILEELEGLGSFVRYDPYLNAWRVHHLFLEYLSGRQGELSEEEKQDVYSKAARWCVENNLKMDAFSYYEKAGSYDAFLEASYTLPPILPSPMAAFLLEILDRAPDSLFQENPLAYLLQTRILFTLKQFDRASAGLREIITQLEIEAPSFFNNRVLTGCYNNLGLIGLITSMHTCDYSYVSFFERAYHYSQLSGHKLTGPATVAPLSSYLCRVSSPEKGEAERYNEAIAAMAPYMSDANGGLGYGMGDMAWAELAFFRVDMANAEQMAYQALFKAQKKNQYEIASRAFFYLIRINLFYGNPEKIEELLKLMEAQLEEKGYLNRYTDYDVQTGWFYAHIGQISRMASWLKNDFEESDLNPMLLGQETLVRVKYYITQKQHLKALRLIENDKDEYGMGAFLFGKIGNKLIEAMCFYDMKDIPWAINSLEEAYYLAAPNGLDMIFIEQGKRTRALFSAVLKHQCSIPREWLEKILRSASAYAKKLYITVEKFQDPDYEDAAGPVILSRRELLVLRGLSRGLTREELADDGDISLNTVKSVIRSVYNKLGAVNRADAVRIATSLGILKSDDLRN
>NC_015578.1|WP_015706878.1|756144_758619_+|helix-turn-helix-transcriptional-regulator
MYLERKRINRLLEKALQNPVVTVVAGAGFGKTRAVLSFLRGEAGLSRWLPVSEWNTHAPVSLRDFRPENPKARCVLVLDDLQFARGPDLSGLLEEFLGAPYPNMRVILISRQELALSKGKVGRITWEDLRFREAEIRDYLLLRNISVPPGMVEEIYQRTEGWAFAVHLAARALEQGRLRAERSLSSIRANIFRFIETEIFNPLPENLKKFLIKLSLIEPWPAALVQELSGDTGLIPLMEGVNSLIVYDPAEKRYRVHGLFLKFLVEKQGELGEGEQQDIYARSAHWYLEHGMKQEALACYGKAGDYRGIIKLVFSLPQIIPQDTARALLELSENLLGEGKDPDFLRRAVRPRLLFILGRFDDAVAASRETIDLYEGRPVSPEDNLILYFAYIILGFASLLSCVHTKRRDFCVFFEQAWVYYRRNPVRLDGPISSANAGPYVCRVGYPPEKNEIPDFINALAEAIPPLADSMGGAFYGMEDLAWAEFALYQGDLLRGEIYSHRALRKAREKGQFEIETQALFFLLRINLAEGRLEQTAELLKQLEAGIRVEFPDQRIRYDIHSGWFFIHIGLPRRLAPWLKNDFDRGALPSLLNGTAALVKAKYFYAQKRYPLALASLEEQKGEYGLGAFLFGKIEMKVLEALCLYRGKRKDAALAALEEAWRMAEGDALEMPFIEMGRDMRTLVSTAIKYEKPGAPREWLERILRKSSAYAKKTYAAAEQYRELYKKASVTAPLSPGVTLTSGTTLTSGVTLTPGTTLTSREMQVLTGLSQGLTREEIARDGGISINTVKSVIRTVYRKLSAVNRADAVRIAIARKILTKNEET
>NC_015578.1|WP_015706879.1|758819_760298_+|helix-turn-helix-domain-containing-protein
MTLNNSNIILRREIEPMLLKARSALQSYEKATGVNVSVLDQAGHSISEEMAQPPEEGRVVAALLATKSPAQETLRLKSALQAADQVGDPSFFCALCRKYSRQDDRVWDDDEYPCTAIHIHSISQAQHAGGVYIYTCEMGFAYWTCPLSTGGRLAGALIAGRVLGVKRQEAVEKIFTMSRGLISREESAGYLEYVPEKSQDEIKSLAQLLLTCAEQISRSPETYHEILKRRAQQQTKLLDQIETLKNQYPSGELVPCYPIEKERLLMASLRRGDNESSRKVLDELLALLFFSNPDNFKFMQYRAIELVVLLSRAAVTSGNTEDALLEMNNQFLLDIQEAQNMEELIDMLYQVVDSMTGQIFSFRGVRHASALRKAERYIWENYTRKLSLQEVATASGLSAPYFSTVFKEEMGENLSGYLNRLRVERAAAMLSGSDFPLSEIAGACGFEDQSWFSKIFKNYTGMSPGKYRIQNCGSGPALSTDNLPVNHHTIGG
>NC_015578.1|WP_015706881.1|761942_762581_+|cobalamin-binding-protein
MVNLSDISNSLQSGKAKETSDLIARAIKENYSVESILRQGLIPGMYAMTNRYKRREIFRPELLIAARAMNIGIGVLRPAIASSAGEPKGAVIIGAVKGDIHDIEKTLAAVTLEGAGFRVIDLGVSVSPERFVEAAVRESAQIILCFSSLPATMPQLKSVVHAASSAGIRSRVKIMITGAPVTEKYCQDIGADFYARDTVGVVEMARAACSNG
>NC_015578.1|WP_015706882.1|762652_765697_+|hypothetical-protein
MSSIKASFLFFLLSVTLIGMNRARFLFVLLLATSLEMPGAQTLKPFTGLRVIRTEHFDIIYPRESEPTARALAGMADGIYDRVSGLLGISLKRRTPVTITPHTEKFNGYMNPLPYPHIVLYDTSMSIEWTVFENSLESLFLHELTHAVSLSSRDPSVEILSAIFGGWVYPTGLTAPMFMVEGVTVNFESLSGFGRANDPLIQQRLRQAIHEDAFLSPFQTAGVYKYPHTTSAHYEYGGLFSAWLCRTYGMEKYAALWKAIGREYHFSFFFYNNGFFNSFKNVYGLTFLEAWGTFKESLRLTTIEENPISPVYTGYTSGPLPFPRQGAIINAVSSGEGKVFFLDNLAQGAFAYDTESGKTRRVIALDSIAYGLDAREDGESFLVSTYRYKGSLARAMVIEYGRKGLQTGHAWPGLYSGRYFRDGVIGLSSELHNNKLVFRSELSGKLFNRKTGEQVLLEGNEELLFGSPVALDDTWIAFIAARKGKRELCLYNFDTRQVYTLGSDLPDDEERWRYIRSLQVSQGKLFFTFNHDRGMYKLGAVDISRIQDGGFPETLDAVFTERNLSGAVAYPVMAGDSIYYAGTFAQWDALMRYPDPAPALSGLRTTLALKPWPAEASIPLTELWPADIPTEVLQAEAKLPPSRGYLGISYLNPLKLWLPLPLIRPEEGSNLSVDGVGIFSFMSDPTDTNLVFLTAFYDIRSPMAAGELQWISYALGFPLIFNLSDDLNKTLTSNYRETRTGISAALSTGLGNERLRFEISPNLDLLFAAPRYTRDSWGQKIDGGDNPYSWDYDQFYYSAGLRMRISNLTLHNWELFGQGLSLTAYGRLQLDRPLDIPRLDGLLTAALEPILPLRLHLYGAWDRDGFNLRGESRYYQNTPFASIALSEYPVQNQIVLEWLAGAEAEMKLFSFDIQRNLSHAYFNRVYGTLAWRGGFYDDQGKAGAEGNYVYDAGTGSYRLAQSLVMRLGFTISTILVTALPVSIDPSVWGAWKISNVNDNINNDFVMGMGFSFSY
>NC_015578.1|WP_015706883.1|765755_767576_+|elongation-factor-4
MAKPEYIRNFCIIAHIDHGKSTLADRLIQKAHLVTDRDFQDQILDNMDIERERGITIKSQAVCLPYIAKDGQEYELNLVDTPGHVDFTYEVSRAINSCEGALLLVDATQGVQAQTLSNMYLAMEHNLEIVPVINKIDMIAADIPATKQQIEHDLGLSAEDALLVSARQGTGVDELFEAIVERFPAPTGDPTAILQALIFDCHYDPYRGVVVHLRIFDGTIKRGMKIRFMHNNSEYEVENLGVFKLALVETDELSAGNVGYIIAGVKTVSDVRVGDTVTNAENPCEKPLPGFREIKPVVFSSIYPVDSNDYEELKTSLEKLKLNDASLIYEKDSSAALGFGFRCGFLGLLHLEVIQERLEREFDQSVIFTAPSVKYKVRLRGNPGHPAEELLVDNPTEYPDEGRIEGADEPYIRAAIITPTTYLGNIMTLCMDKRGVQTNMTYLDEKRVEMVYDMPLSEVLFDFYDRLKSISRGYASFDYDVTEYKPTELVKLDILLNGKGVDALSQLVFKGNAYDRAKIVCERLRDEITRQQFKIAIQGSIGSQIIARETVNALRKDVLAKCYGGDISRKRKLLEKQKEGKKRMKMVGDVELPQSAFLAVLKSKDE

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Crispr_ID: NC_015578_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015578_5

988679-988903

Orphan

Consensus_repeat	Method
AATCAAGCCACATCTAGCGGCGGCGGGGTGTCTGTGACA	PILER-CR

2 spacers

The CRISPR arrays of NC_015578_5

>merge|NC_015578|5|988679-988903|PILER-CR
AATCAAGCCGCCTCTAGCGGCGGCGGGGTGTCTGTGCCAGGTGGCGTGTTTACCCTGGATGGAGGGACTATCAGCGCCAATACTGTCGACGATGGCTTGAGTGGCGGCTTGGGCGGCGGGGTGTCTGTGACAACGGGGCTGACGACGTGGGGTAAGTTTGTCATGAAGACAGGAAGCATCGGCGGTAATCAAGCCACATCTAGCGGCGGCGGGGTGTATGTGAAG

>NC_015578|5|1|988679-988903|PILER-CR
AATCAAGCCGCCTCTAGCGGCGGCGGGGTGTCTGTGCCA	GGTGGCGTGTTTACCCTGGATGGAGGGACTATCAGCGCCAATACTGTCGACGATGGCTTGAGTGGCGGCTTG
GGCGGCGGGGTGTCTGTGACAACGGGGCTGACGACGTGG	GGTAAGTTTGTCATGAAGACAGGAAGCATCGGCGGTAATCAAGCCACATCTAGC
GGCGGCGGGGTGTATGTGAAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_015578.1\|WP_015707100.1\|1003660_1004272_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NC_015578.1\|WP_015707083.1\|973955_975326_-\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_148257403.1\|976327_977710_-\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340831
NC_015578.1\|WP_015707092.1\|990977_992747_+\|cadherin-like-beta-sandwich-domain-containing-protein	unknown	unknown	gnl\|CDD\|378939
NC_015578.1\|WP_015707086.1\|978988_982519_+\|adenosylcobalamin-dependent-ribonucleoside-diphosphate-reductase	unknown	unknown	gnl\|CDD\|236049
NC_015578.1\|WP_015707081.1\|972110_972980_-\|metal-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224046
NC_015578.1\|WP_015707089.1\|984246_986280_+\|cadherin-like-beta-sandwich-domain-containing-protein	unknown	unknown	gnl\|CDD\|378939
NC_015578.1\|WP_015707093.1\|992759_996047_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|185219
NC_015578.1\|WP_015707085.1\|977924_978812_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|273806
NC_015578.1\|WP_052299695.1\|975377_976325_-\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|319852
NC_015578.1\|WP_015707082.1\|972976_973954_-\|zinc-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238500
NC_015578.1\|WP_015707091.1\|989492_990779_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015707099.1\|1002450_1003638_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|226951
NC_015578.1\|WP_015707088.1\|983546_984023_-\|S-ribosylhomocysteine-lyase	unknown	unknown	gnl\|CDD\|376888
NC_015578.1\|WP_015707095.1\|997338_999288_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NC_015578.1\|WP_015707087.1\|982627_983527_+\|alpha-hydroxy-acid-oxidizing-protein	unknown	unknown	gnl\|CDD\|376451
NC_015578.1\|WP_015707096.1\|999289_1000927_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015707098.1\|1001628_1002339_-\|5'-methylthioadenosine/S-adenosylhomocysteine-nucleosidase	unknown	unknown	gnl\|CDD\|350159
NC_015578.1\|WP_015707097.1\|1000975_1001629_-\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015707094.1\|996040_997330_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_015578.1\|WP_148257403.1\|976327_977710_-\|glycosyltransferase-family-4-protein	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	0.000296603
NC_015578.1\|WP_052299695.1\|975377_976325_-\|HAD-family-hydrolase	gnl\|CDD\|319852	cd16415, HAD_dREG-2_like, uncharacterized family of the haloacid dehalogenase-like superfamily, similar to uncharacterized Drosophila melanogaster rhythmically expressed gene 2 protein and human haloacid dehalogenase-like hydrolase domain-containing protein 3. The haloacid dehalogenase-like (HAD) hydrolases are a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members include 2-L-haloalkanoic acid dehalogenase (C-Cl bond hydrolysis), azetidine hydrolase (C-N bond hydrolysis); phosphonoacetaldehyde hydrolase (C-P bond hydrolysis), phosphoserine phosphatase and phosphomannomutase (CO-P bond hydrolysis), P-type ATPases (PO-P bond hydrolysis) and many others. Members are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	3.91969e-16
NC_015578.1\|WP_015707086.1\|978988_982519_+\|adenosylcobalamin-dependent-ribonucleoside-diphosphate-reductase	gnl\|CDD\|236049	PRK07562, PRK07562, vitamin B12-dependent ribonucleotide reductase.	0
NC_015578.1\|WP_015707081.1\|972110_972980_-\|metal-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224046	COG1121, ZnuC, ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism].	6.192e-76
NC_015578.1\|WP_015707089.1\|984246_986280_+\|cadherin-like-beta-sandwich-domain-containing-protein	gnl\|CDD\|378939	pfam12733, Cadherin-like, Cadherin-like beta sandwich domain. This domain is found in several bacterial, metazoan and chlorophyte algal proteins. A profile-profile comparison recovered the cadherin domain and a comparison of the predicted structure of this domain with the crystal structure of the cadherin showed a congruent seven stranded secondary structure. The domain is widespread in bacteria and seen in the firmicutes, actinobacteria, certain proteobacteria, bacteroides and chlamydiae with an expansion in Clostridium. In contrast, it is limited in its distribution in eukaryotes suggesting that it was derived through lateral transfer from bacteria. In prokaryotes, this domain is widely fused to other domains such as FNIII (Fibronectin Type III), TIG, SLH (S-layer homology), discoidin, cell-wall-binding repeat domain and alpha-amylase-like glycohydrolases. These associations are suggestive of a carbohydrate-binding function for this cadherin-like domain. In animal proteins it is associated with an ATP-grasp domain.	1.76806e-07
NC_015578.1\|WP_015707093.1\|992759_996047_+\|hypothetical-protein	gnl\|CDD\|185219	PRK15319, PRK15319, fibronectin-binding autotransporter adhesin ShdA.	7.88715e-08
NC_015578.1\|WP_015707085.1\|977924_978812_+\|hypothetical-protein	gnl\|CDD\|273806	TIGR01784, Uncharacterized_protein_pSLT051, conserved hypothetical protein (putative transposase or invertase). Several lines of evidence suggest that members of this family (loaded as a fragment mode model to find part-length matches) are associated with transposition, inversion, or recombination. Members are found in small numbers of genomes, but in large copy numbers in many of those species, including over 30 full length and fragmentary members in Treponema denticola. The strongest similarities are usually within rather than between species. PSI-BLAST shows similarity to proteins designated as possible transposases, DNA invertases (resolvases), and recombinases. In the oral pathogenic spirochete Treponema denticola, full-length members are often found near transporters or other membrane proteins. This family includes members of the putative transposase family pfam04754.	0.00404218
NC_015578.1\|WP_015707092.1\|990977_992747_+\|cadherin-like-beta-sandwich-domain-containing-protein	gnl\|CDD\|378939	pfam12733, Cadherin-like, Cadherin-like beta sandwich domain. This domain is found in several bacterial, metazoan and chlorophyte algal proteins. A profile-profile comparison recovered the cadherin domain and a comparison of the predicted structure of this domain with the crystal structure of the cadherin showed a congruent seven stranded secondary structure. The domain is widespread in bacteria and seen in the firmicutes, actinobacteria, certain proteobacteria, bacteroides and chlamydiae with an expansion in Clostridium. In contrast, it is limited in its distribution in eukaryotes suggesting that it was derived through lateral transfer from bacteria. In prokaryotes, this domain is widely fused to other domains such as FNIII (Fibronectin Type III), TIG, SLH (S-layer homology), discoidin, cell-wall-binding repeat domain and alpha-amylase-like glycohydrolases. These associations are suggestive of a carbohydrate-binding function for this cadherin-like domain. In animal proteins it is associated with an ATP-grasp domain.	0.000124644
NC_015578.1\|WP_015707082.1\|972976_973954_-\|zinc-ABC-transporter-substrate-binding-protein	gnl\|CDD\|238500	cd01018, ZntC, Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. They are comprised of two globular subdomains connected by a long alpha helix and bind their specific ligands in the cleft between these domains. In addition, many of these proteins possess a metal-binding histidine-rich motif (repetitive HDH sequence).	5.18172e-77
NC_015578.1\|WP_015707100.1\|1003660_1004272_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	4.48542e-44
NC_015578.1\|WP_015707099.1\|1002450_1003638_+\|ATP-binding-protein	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	2.33631e-34
NC_015578.1\|WP_015707088.1\|983546_984023_-\|S-ribosylhomocysteine-lyase	gnl\|CDD\|376888	pfam02664, LuxS, S-Ribosylhomocysteinase (LuxS). This family consists of the LuxS protein involved in autoinducer AI2 synthesis and its hypothetical relatives. S-ribosylhomocysteinase (LuxS) catalyzes the cleavage of the thioether bond in S-ribosylhomocysteine (SRH) to produce homocysteine and 4,5-dihydroxy-2,3-pentanedione (DPD), the precursor of type II bacterial quorum sensing molecule.	1.62658e-78
NC_015578.1\|WP_015707095.1\|997338_999288_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	2.19991e-05
NC_015578.1\|WP_015707087.1\|982627_983527_+\|alpha-hydroxy-acid-oxidizing-protein	gnl\|CDD\|376451	pfam01070, FMN_dh, FMN-dependent dehydrogenase.	3.29537e-67
NC_015578.1\|WP_015707098.1\|1001628_1002339_-\|5'-methylthioadenosine/S-adenosylhomocysteine-nucleosidase	gnl\|CDD\|350159	cd09008, MTAN, 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidases. This subfamily includes both bacterial and plant 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidases (MTANs): bacterial MTANs show comparable efficiency in hydrolyzing MTA and SAH, while plant enzymes are highly specific for MTA and are unable to metabolize SAH or show significantly reduced activity towards SAH. MTAN is involved in methionine and S-adenosyl-methionine recycling, polyamine biosynthesis, and bacterial quorum sensing. This subfamily belongs to the nucleoside phosphorylase-I (NP-I) family, whose members accept a range of purine nucleosides as well as the pyrimidine nucleoside uridine. The NP-1 family includes phosphorolytic nucleosidases, such as purine nucleoside phosphorylase (PNPs, EC. 2.4.2.1), uridine phosphorylase (UP, EC 2.4.2.3), and 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP, EC 2.4.2.28), and hydrolytic nucleosidases, such as AMP nucleosidase (AMN, EC 3.2.2.4), and 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase (MTAN, EC 3.2.2.16). The NP-I family is distinct from nucleoside phosphorylase-II, which belongs to a different structural family.	4.0985e-99

>NC_015578.1|WP_015707089.1|984246_986280_+|cadherin-like-beta-sandwich-domain-containing-protein
MNIRVKCFFAGLRLLAALVLTALFSACPQVEGVKASDNRLLSITASRGDLSPLFNPDYTDYELLVPFDAESVRLEAVPGDGGARVSPGRVVEKPLGPVDTVVVFTVYPQDWSAVRDYTVTVRRKSPVSKNTNLASVWVADKDGNKWPFSDYHNDNDEPLAFSPGLTAYTVKVPNSMERIALICTPTNENAAVSDTGHYKKTAEYTYTELAVGIPEEINVTVTSEDRTETKTYTFTVTRAAPDPGNNRLRRLWINGKLAADFKGSDAAYTANVSWADSVTLKAEAEELGARIYDSTDTAINPEGSAVTAVQDLPFSGAGVITYTLRVASVDGSDMAYTITLTRLSKDASLGSITVTATAAGSLETWTPALIDFLPTDDRSWAYGTEETPLITTQSANITVTGTLPTGSLAQISSPLENTLSEGVHCLTLTVTAQDTTVRHTYSIWLERLPVDSNADLSNLQVQAGGMTHTLISSSPSPETNYSLSIPAATAGVTITATPASSLAKTLTVKGSNVSFGASRNVTEISPGITTIPVVVTAQDGTTKTYVITLYKPGTAGLSITLLLSDGGDFITIDRDLPDSNIFIYQNGIASGAGHQDLPRTVEFSFTGETGYWWYVDGKKKGNNNESLLIDALNYSLTKHRVTLMVQQGDIIISREIFFTVTMNVVEDGFDDLPSYSY
>NC_015578.1|WP_015707088.1|983546_984023_-|S-ribosylhomocysteine-lyase
MEKIASFQVDHLRLKPGLYVSRKDKFGSTILTTFDLRFKEPNKEPVIDVPALHTIEHLGATFLRSHKEWAPKTVYFGPMGCRTGCYVILEGDWDSQKVLPLIRELLDWIIAFEGDIPGAAPAECGNYSEQNLNIAKWEARRYAAVLKNPGKENLNYPD
>NC_015578.1|WP_015707087.1|982627_983527_+|alpha-hydroxy-acid-oxidizing-protein
MGEGDKVQTSVETLRDYFDSLLVELRVIDSVEASTGMTLYGHSFATPVMEAALSGLDKVRPNGTVEAAKGVAAAGAVMWTGIGSEEELESIIAAGAKTIKIIKPYADKDLIFKKIEHAEKAGAIAVGMDIDFVFGGKSKKGFAMEYPVSPKTLDDVKSFVKATKLPFILKGILSERDAEKALEAGAGGIVVSHHGGIVDCAVPPLQILPRITKLIKRRIPIFVDCGITRGTDVFKALALGATAVSVGKVIMPALKNDGAPGVQKVFEEITAGLNWVMSLTGSRDLEHIDPAVLWNKLTQ
>NC_015578.1|WP_015707086.1|978988_982519_+|adenosylcobalamin-dependent-ribonucleoside-diphosphate-reductase
MNYQRLFTEPRSGPYKDIQWEKRRSEIRNPDGKAIFEEDTVIVPSFWSQIATDIIAQKYFRKAGVPADKASAWKDWAGDSPGFPLPEDGAEHDSRQVFHRLAYTWMDWGKKNRYFDSDEDARTFYDETCYMLAHQLAAPNSPQWFNTGLYAVYGIDGPAQGHYYFDPEDQKLKKSDSAYKRPQPHACFILSIEDDLVNEGGIMDLVTTEARLFKYGSGTGSNFSRLRAAEEKLSGGGVSSGLLSFLKIGDRSASAIKSGGTTRRAAKMVILDADHPDVEKYVEWKAGEEHKVASMVTGSAVVKKRLEGIKKALSDFRGPDADAFNAEKNHELAAAIRNALNDKIPPTYLYQLLGQLEQGDQGVNPKLFTTAWDDEAYNTVSGQSSNNSLRVSDGFMQAVTEDDDWNLVSRTSRKPVKTIKARQLWDQVARSAWQCADPGLQYHTTINDWHTCPAGGEIRGSNPCSEYMFLDDTACNLASINLAALYNRETREFNVEGYLHAIRIWTSILEISVVMAQFPAPKIAQLSYEYRTLGLGYANLGTLLMLMGLAYDSAEGRALAGAFSALLSGEAYAQSARMAANLGPFLHYADNKDAMLRVIRNHRRAAYNAPAADYEVIHTPPMGIDPAACPVYLLEAAKAAWDRALELGSAHGFRNAQVSAIAPTGTIGLLMDCDTTGVEPDFALVKFKKLAGGGYFKIINQSVPPALEALGYSPEQIDGIIAYATGRKTLSGAPAISPEALTEKGFTPEALAAAEDAVKTALGLDGVFNPWILGKDFVEKTLKVPESTWSLLGFSLLKHLGFSDEDIAGAELYACGTMGLEGAPHLKQEHLSVFDTATPSGKNGRRSIPWTAHIGMMAAAQPFISGAISKTINMPNNSGYEDVKGAYMLSWKSALKAVALYRDGSKLSQPLSSFAPGTDPLADTILAVERGLENPALAEERKFPAAGEGASGSRSKRKPLPNRRVGYTQKAKLGGHSIFIRTGEYDDGALGEIFLDMHKEGAAFRSLLNSFAIAVSLGLQYGVPLEEYVDAFTFSRFEPNGMVQGHDYVKMATSVIDYIFRDLAISYLKRTDLGQIKPEDIDDNNSPKNEAPANSAGRHINSKIMRGASSQAAHRDSPAKAVVPGPSLQDTGAIKIAQARIKGYEGDPCPTCGSFTLVRNGTCMKCDTCGGTTGCS
>NC_015578.1|WP_015707085.1|977924_978812_+|hypothetical-protein
MPRPRNSKKEKSSGRNPGSRVSGSKLNWHSAFFQAIQRELADYKDALEFRHEYQLTAEPLRIDMVIIKKPPALAISKNIARIFRAENLVEYKSPGDYLSVRDFHKVYAYANLYAAITPGIRFSDLTITFVEKRHPRELIRYLTNERHYTIEEPWPGIHLVQGDYLPIQIIESKKLSPRENLWLKSLSDDLETEEAHAILREDVTQDIGLDAYLQILYQANSKSFWEATEMPKKETFEEFFTKVGLIPEWLERGREQGAIKIAQNLLKEGMSVEKTAKIAELPVEKVRSLKLPAKV
>NC_015578.1|WP_148257403.1|976327_977710_-|glycosyltransferase-family-4-protein
MILNQARALIEGGDDALIITGVLNPDAPDLNQVLVEELRYDREQPLPPPEGQEQWLKDRGVVLAAAITRAMQAHWGREADIIHVHNPLLRKNTALLPALALLQERYGGLLLQNHDLAEDFRPDVYVGKEEYPANCHYAVINSRDYSFLHRSGLKTEGLHLLPNEVHPIKATPGLERKRYLYPVRGIQRKNLGEALLLSLFIPKGKTVAITLPPTMEKDFQIYNAWVNFARELGLPVEFNAGQDSSLEDLYGSAEGVISCSVKEGFGFSFLEPWTAGRAVLGRRIDYVCKDFESSGVRFNSLYSALNIPMVYISPSILREKMEYAMSSVYKSFGIVPPRHTINMLGNDLLSRDLVDFSRLDEKTQEGIIRVLDANKSVFRDIADVNPFLGELESWRPDEDLIEANRLHILDSYGRQTILELLRETYRSVLDTQVTHKISKSILLELYLDPLRLSLVGVGHD
>NC_015578.1|WP_052299695.1|975377_976325_-|HAD-family-hydrolase
MADPGLLRLIRESPVPPALPPPTLPADLEALLFPPRAGGAFPFKGIHTVIFDVYGTLFSSAAGDISGAGDRAASNERLEALARELGCTAQELGDHFHREVQRLHGELGEKTPYPEVRVEEIWADFLNRCNGPAGGPAGDRAAGGLAGAEKLPLSARELALRYELAVNPVSPMPGAGETLKMLKARGIRLGLISNAQFFTPLLFEAFFGALPEKLGFDPDLLIYSYELGEAKPSPALFTPPVRCLESLGLDTRHALYIGNDMLNDVYAAARAGFTALLFAGDARSLRLREGHPLAGNTRPAAVIRNLGDIGGLLGF
>NC_015578.1|WP_015707083.1|973955_975326_-|hypothetical-protein
MYKPYTMPVIQAFPDIKVSEPNFSKLITFLMKILMRPYLFLFFGVARVFLGGKKHFFGAFERALRGDTRCIMAFRHPNGGEPQLLTWFILFRLGALAKKEGIAFAKRPRALFIYGYEVLRWGGWVARLVMPGLGAMPIYHAKIDSQGLGRIYQDLLSGPYPLAMAPEGQVTYNVERVLNLEQGTMRIGFSVAERLIQAGKSFPVEILPVSIHFRYGIWGKICLKWLMKRIEKFTGFSALYKKEEVPDFTTRLRNCRDYLIAKNESRYGIARDENRTVPDRITLIIEAGLRRAEQILGIKPTSGETISRLYLIRQICWDRIFLPGRDTLKGLPRLERAQLDLAAGEAWHACRHTEVVDFIWYFHSALPEENAPLHEKIEFAQNLWDFANRTMGGSYATRNINIYPRRVIIQAAAPINLTERLPAYQKDRKATIQTAMDDLLQSYLNCIKEVNETEKE
>NC_015578.1|WP_015707082.1|972976_973954_-|zinc-ABC-transporter-substrate-binding-protein
MNLPLLAVRGRTTIVTRFSLFCFLIILTLNGCGENTTKGAQKKAPAPDTPVLAVSTIPQEWFARRVSGTCNEVSSTDRLRILTLVGPGQNPHSYEPGPKQMADLAAARAWVLSGTEFELSLKPKIEALFPNLRIINGTAGVRFRTLEAHDDGDVDHVDEGSLDRHTWLGQEPAKIMAGHILEACIAIDGDGTAYYQKNYEELIADIDQEFAELGIKLAPLRGRTVFVYHPAFGYFLDEFGITQEAVETGGKEPTPRVLNALIEKARREGAAAIFVQAQFPVASARTVAAAAGAVIAALDPLAPDWLANIRDMGDLLLKSLEEAKK
>NC_015578.1|WP_015707081.1|972110_972980_-|metal-ABC-transporter-ATP-binding-protein
MNSHLTHPRDRQISLRFDRVSFSYGGASDSRKASSGRKEPSSRKVLENASFHIHQGEFIALVGPNGSGKTTVLKLLLGLEQPQGGRIELFGARFTPGARNRVGYVPQQAANDQSFPITVREAVKMGRLSPLSRKFGAVDQAAVEEALEQAEIADLAERSYTALSGGQRRRVLVARALAAKPEILILDEPTANMDRESEERLFATLGKLKAGEGGRITTILIVTHDTGFVSSLTDRVLCMGSREAGAEYGIVQHRTEVAGEGHDAGALGARIVHGESLPGDICDEEEIHK
>NC_015578.1|WP_015707091.1|989492_990779_+|hypothetical-protein
MSCLKNKSPGLFTAALALSALLSVSCEQPETDILALVDQKVWEANAPRIQVSYEVDSDKGLTIPSVSSEAKQRLPFTVSYTPINQEWAFAQWTAYHDSTPLTSGDIYFENSSNTVTQVIILTDKYDRITLKPQLEERLRVWDWRPNGGTDTPLVKNTSIVVRFTQNIAGESFIIRNEQGRLQYDENYEPVYRAAGEFRNITILGSSYGNEPVNFARYFNDPVIQGDTLRLEPNPLDAIPSYSYITVILGQGINSSGTQVTLSAPFLFQYAVSNKFDDEGPHILFFGVSGDDGETLSFAAVGEEDAPVGDFTLHPGVPLYFMVSANDTISGMNIGQIRITEIAEGVSYPPQAHWYTGDYNDPLRQNLIKNAEKIYDSSGTNKLEGIHIFSYTPLARTETYDYTGPMELQVDVLDPQGNSTTRSYPVYRE
>NC_015578.1|WP_015707092.1|990977_992747_+|cadherin-like-beta-sandwich-domain-containing-protein
MKKRGKVFFSGLLLAAGILVSACNQAVGSENSGDLLQTILVYGGTEVLQLQGVHREWPGFDPRETEYTLAVPAHIESITLEAAPRDISVRISPQKQIEKHFSYGESAEITFTVYSADWGSVQTYTITASRESPVSRNAALAEVWVRDQNGNQWPFSDYTGEDGKNLNFFPSVTSYFLKAPSTMSQIALVCTPADTKAEISGTETYPLSFDGPREIPIRVTAQDGTGETYTFTVTRTAPDPENNTLRHLWVNGLVIDESDDKVSVSTGPEGNLVYTIKVPYNEKATLRAEAAEYGATIADGAGAGLTSGDSAVTEERELSFDGTDTLSYTMKVQSEGGSQEYTVNLVRMSIDAELSGISINGAPLSGFDRTIMSYGSSTTPKITTTAETINVSGTLSDPNGAVNALDNHPLALGSNRLTLTVNAEDPGYRNTYTIWVRRNSIPGTGSEPGGGTDPGGGTDPGGGTDPGGGTDPGGGTDSGSGGAAPAFTLSLPTEITGITGSPADGTALIYKQGTVGDSDKPRSFTVSVPTGQGLTVYGWYVDGLQRGSEYSFNVDAVSYPLGTHRVSVIILKNGKHYSYEKTFTVHYDK
>NC_015578.1|WP_015707093.1|992759_996047_+|hypothetical-protein
MKKANRIIILWALVCIFLLWGCSDILKESVNFELPENKGLVLVIINGSDGAGRTLLPKAPDFVRYDLVFTKGAAEESYPDWKTTDVISLNVGEWALELTAYVAGAALPLAAAKGNATVTVSPSAPATVNVSLYALTGGQGTLSYNITLPTDLSSAQMIVSPFAGGSDQTVDLLLSGASGSLPLASGDYRLTLTLNKDGLPAGKTVALQIYDNLVTEATYEFKDADFSSAVTISGPVPTKTGYTVTEIYIYSSAGQKIDAAVGGINTAKTAWSFTVPSGYESVYFKVEVCKDGTLAPKFLSKPIALDQLQSHDGEGAIALDFTYAITIPTSLSGGSVTAVPVEAFEGQTVTLTMHPDSGKQFKGGSLKYKGITQEKGVILETQTVSGDETASFVMPAEDVGIAAEFKTPLTAGLFKKNAAESLEEITGDYTTHSLANALSYIKTSASVSPGDRFVIILGETTNATLSPASSTGDSTGYLSKAVTVTLQGSGAAREVSLDNSGSLFVVGNNAELILGDKIILQGRNSNGYSLVRVEGTGKLTMQSGSEIKGNKTSASVSGGGVSVTSGGTFTMDGGTISGNYAASNGGGVYVTSGGTFTMNGGTISDNTHNASSSFSGGGVFVETAGETTSKFFMNGGAINRNTSSSRGGGVSVLSGTFTMTGGTISGNISATAAISASSGGGVSVSGGTFIMDGGTISGNTASATDSSATTSGGGVSVSGGTFTMNDGTISGNTTTTTTYSTSSGGGVSVSSGAFVMTGGTISGNTATSPNDNNPAAYGGGVNISGGAFEMTGGAIIGNATTSSPTSPSIKINGGGVYVSGGTFTMKDGLISANTAPFGGGVYVSGGTTKFVEKASLSANIAEEGGGVYVSGGSFTLAGGAINGNIANGGSYSRGGGVYVKTGIFTISDGTLDNNSAIASVASYGGGVYVGGGTVNMTKGTITANISSCESYSYGGGVYLDGGKFTISGGTFSNNTASSLTPSYSRGGGVYVYTGTFEMAELGRIDTNNLVCIEPGKWITLTKPFTGAGPIALIDLSGSSSSWLPPIKVLKKETSFGTQDIPLDRFLLGDFVIGPQRKSIEAMGYFLNTDGTLQSW
>NC_015578.1|WP_015707094.1|996040_997330_+|hypothetical-protein
MVAKLTLPVYGRPLVLGFLAALLAASCDLSGETDILAVVDQKVWEASAPRIAVSYSVENDKGFTIPAVSGEAKQKIPFTVTYTPLNQDWAFTGWTALDPSGKVLASRDIYFEEPNNSSTQVIILTDTYSRITLKPVLAERPLVWDWHPNGGTDNPVNINTPVVVRFTKPMRVESFVFRYDAKGDPVWRNESGEFRNITILGSPEFGTREPVNYAPWFLDPQLNGDTLKLEVNLAYAREHSLAYSYISVTLGQEISSADYVTLSAPVRFQYAVNDGFDTEGPVIRRFSAALPAEEGEDPVELPYGNPDHPQRHLAPGAQLDLIISALDQISLADIRQIEISEKKADGSAVSGPITFWYTEDYQKPEWQTLIADVEKNYGNLSGLHIFRYEFKGAPEYQGYIDLQADVYDPLGNFSTALYRIYQEGPEITE
>NC_015578.1|WP_015707095.1|997338_999288_+|tetratricopeptide-repeat-protein
MKTRLILTVFILAITASAFSVEFTLRPRFFALFPLGDKTVERFDTGFGGDLLFDVNISSLLTNPWGIGYSAGLEGGAGFTPLKTDAADSISFLSGGLGLGVFYYPISRLNLRLDGALGLYQGSLSSGGNSAEGSESSLWWRAGAEAGFRFSPLITLSANVGYRYYNNRFSESTGPAFYSGLYTGLTLQLNFETRSSYRGIDVRLDQDDGIYPLYHSLYRNNPVGSLILTNRESAEIRNVRVSFQAGSYTSSELFCGSVPLLVRGRSTEIPLLADFSRALMDFTADGRIIGEVLVRYTLLGAERTALLSVPVQVHGRNSFLWADPWGLGAFVSPTSADTLEFSKQITGLARGSLRPELNRNMQLGIWLFEGLKAAGLGYGGPLETPYVEYRQSPEKIDDIQYPFQTLAFRTGDLDDLGLLFAAILEAAGISSAYIPLDDEFIVAWPLNISEAQAGNFFKDTEKLLVVNGEIWLPLALSGFNDGFIAAWDKAGERLNRAEASGEGFEFIPSADAWTVYPPAAAPPLRNRNTRPDENAAAAAVERALKSYIDQELAPAIVRLQEQIRGGATPALYNQLGLLQLRAGSHRDAQRTFEQAAGMGSLPAMLNLGNLFLMDDDWNNAESWFNRALDTDPEYEPAKRGLERVRAGRG
>NC_015578.1|WP_015707096.1|999289_1000927_+|hypothetical-protein
MKKRNSPVLFALLFFLPILSIHAEQGLEFRLAPGGAFPLSENRFEPGFGLSAALDWTFLPLGRLFKTGPLQDRLNAGLSGQGGLGSLGVKDGSSLSLLDLGLGPLVRLDLGERFSLEITGNLGIYQLSYDQLKQSALRWGGTLSGAFRLAPYLSVFLNGGYHRYEYNREPLAQTLSIGAGLSINLLELIRPQTRIKAEKTLDNPVFPVSFAWYEDNPLATVRVTNNERNTLRDLRLSFFLEQYMNEPFLLPGIPQLKPGESVDIPVTALFNGTMLDLEENTNANARIILSYRNLGSRREADFPLEIPVYHRNAMNWDDDRRAASFVSPRDSAAQLFARYTASVVDRRLRPDTPRNIQYALGLLAALQEYGIHYIIDPSSSYLELSENASALDNLNYPYQTLLYHGGDCDDLSILFCSLLEVLRVDTAFITIPGHIYAAFDTGLEAPAEDQESDGGFIVYDDRLWMPVEITIPEKGLYRAWQTGIEQWRSAGEEGKFYPMGDSWAVYPPVSVGEAGRDPPALPGEDALIGAFEKEMEGNFSKKTGK
>NC_015578.1|WP_015707097.1|1000975_1001629_-|hypothetical-protein
MPASCNAVPRARKLTPGKIVKLIILCAFATGCNFLLNTLICEVFLLPLFLDTLFTCAVCFAAGPIPGILTGILTAVLIVLRTEQVTTYYYILCSIAEVLLIWSFCRSWAENTEPESASPISKIAILLLVFITDSGMLSVLGGIIDFVIHVVLLQKNILFSPEDAFKLGLLRNNVPLLAADVLSRIPINIVDRFIVIFGGYFLAQPVKKFLRGKRPVR
>NC_015578.1|WP_015707098.1|1001628_1002339_-|5'-methylthioadenosine/S-adenosylhomocysteine-nucleosidase
MIGIIGAMEEEISLLRSALEDSRLETIGGYKFYIGKLENKPVALLLCGIGKVSAAVGCALLIDHYHPELVINTGSAGGIDPALSFGDAIISDGLVYYDADVTAFNYALGQIPGMPPIFPVTEDLIRRAEAAVDSLKREGILPENFNHCRGLIGSADIFMHEPEMINELRKRFPTLRAVEMEGAAIAQACYIFKVPGLIIRALSDIAGTESPVTHDQFLPIASKHSGEIVRRIVREW
>NC_015578.1|WP_015707099.1|1002450_1003638_+|ATP-binding-protein
MALLCRCIVIALPIFGTEYSSITGVFADWMEVEKALSGNPAENGALLSSLMKFRLTLEAYTESPLFMQYEGAVLFSLEQKQQMMELIETFAESAARGNMAEAAENAVAIRSTLVFWQHFEVTVSNTVFAKTFSLFVFFILIIAALIYFLWHQQSALQYSRRQNQEAADLSRRIILAQEAERSRISMEIHDTVLQDLGRLMQLTEEYGAKTGQGSEAILAMEDRLITQLRMVCRVIMPPNFSRLLLADSLMQLCFDFEKRTRVKCQASISEDISAEGLQPDMQLQCFRIVQEALTNIEKHAHATEVSLTVRNSQKGERPTLLIILSDDGCGIEDDSLIGPYPLSAANRAGEDVFGIRGMYERTSILKGDLAFINEIGQGLTVRIEIPLGISKSFSF
>NC_015578.1|WP_015707100.1|1003660_1004272_+|response-regulator-transcription-factor
MKTLVLIEDHDMMRRGLASYFSQQKRWEVVGEAATLDEASALFETLVKTGVPLPDIVLLDIDLNGAWGLDLVPKLREWYGKKPPVLVYSVFDDYAHVKAATRAGVAGYVCKSQREAELETAMDTILQGDIYFTPYLFPKISAVSDITIFLTKRERQIFELVQRLYSNDRIAGELGINIRTVENKLSIIYDKIGVKSRGELEKL

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Crispr_ID: NC_015578_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015578_6

1386570-1386687

Orphan

Consensus_repeat	Method
GGCGGCGGGGTGTATCTGTCCGGCGCCGGCGCAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015578_6

>merge|NC_015578|6|1386570-1386687|CRISPRCasFinder
GGCGGCGGGGTGTATCTGTCCGGCGCCGGCGCAGATCTGACCGTAACTCAGTATGGAAGCATCAGCGGCAATGCGGCGGAGACCGGCGGCGGGGTGTATCTGTCCGGCGCCGGCGCAG

>NC_015578|6|5|1386570-1386687|CRISPRCasFinder
GGCGGCGGGGTGTATCTGTCCGGCGCCGGCGCAG	ATCTGACCGTAACTCAGTATGGAAGCATCAGCGGCAATGCGGCGGAGACC
GGCGGCGGGGTGTATCTGTCCGGCGCCGGCGCAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_015578.1\|WP_015707439.1\|1374709_1375864_-\|aminotransferase-class-V-fold-PLP-dependent-enzyme	unknown	unknown	gnl\|CDD\|224029
NC_015578.1\|WP_041611490.1\|1401777_1402614_-\|epoxyqueuosine-reductase	unknown	unknown	gnl\|CDD\|224516
NC_015578.1\|WP_169313407.1\|1380243_1380408_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015707437.1\|1373154_1373445_+\|antitoxin	unknown	unknown	gnl\|CDD\|227620
NC_015578.1\|WP_015707444.1\|1380424_1380676_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015707454.1\|1403062_1403377_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|373040
NC_015578.1\|WP_015707446.1\|1381368_1384683_+\|cadherin-like-beta-sandwich-domain-containing-protein	unknown	unknown	gnl\|CDD\|238020
NC_015578.1\|WP_015707445.1\|1380685_1380934_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015707448.1\|1389913_1393204_+\|cadherin-like-beta-sandwich-domain-containing-protein	unknown	unknown	gnl\|CDD\|378939
NC_015578.1\|WP_015707449.1\|1393219_1396744_+\|nuclease	unknown	unknown	gnl\|CDD\|379528
NC_015578.1\|WP_015707438.1\|1373528_1374710_-\|tRNA-4-thiouridine(8)-synthase-ThiI	unknown	unknown	gnl\|CDD\|234960
NC_015578.1\|WP_015707450.1\|1396873_1397287_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_148257420.1\|1399362_1401744_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NC_015578.1\|WP_041611047.1\|1403450_1404536_-\|DUF362-domain-containing-protein	unknown	unknown	gnl\|CDD\|377193
NC_015578.1\|WP_041611044.1\|1376003_1376321_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223713
NC_015578.1\|WP_041611489.1\|1377656_1380140_+\|bifunctional-aspartate-kinase/homoserine-dehydrogenase-I	unknown	unknown	gnl\|CDD\|181856
NC_015578.1\|WP_015707453.1\|1402806_1403109_+\|BrnT-family-toxin	unknown	unknown	gnl\|CDD\|367913
NC_015578.1\|WP_015707441.1\|1376325_1377411_-\|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	unknown	unknown	gnl\|CDD\|133463
NC_015578.1\|WP_015707456.1\|1404661_1407202_+\|alpha-glucan-family-phosphorylase	unknown	unknown	gnl\|CDD\|340852
NC_015578.1\|WP_041611046.1\|1397339_1399262_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809

Protein	Function_ID	Function_description	E-value
NC_015578.1\|WP_015707439.1\|1374709_1375864_-\|aminotransferase-class-V-fold-PLP-dependent-enzyme	gnl\|CDD\|224029	COG1104, NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism].	8.22539e-104
NC_015578.1\|WP_041611490.1\|1401777_1402614_-\|epoxyqueuosine-reductase	gnl\|CDD\|224516	COG1600, COG1600, Uncharacterized Fe-S protein [Energy production and conversion].	2.33755e-19
NC_015578.1\|WP_015707438.1\|1373528_1374710_-\|tRNA-4-thiouridine(8)-synthase-ThiI	gnl\|CDD\|234960	PRK01565, PRK01565, thiamine biosynthesis protein ThiI; Provisional.	1.83233e-155
NC_015578.1\|WP_015707446.1\|1381368_1384683_+\|cadherin-like-beta-sandwich-domain-containing-protein	gnl\|CDD\|238020	cd00063, FN3, Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.	0.00667472
NC_015578.1\|WP_015707454.1\|1403062_1403377_+\|hypothetical-protein	gnl\|CDD\|373040	pfam14384, BrnA_antitoxin, BrnA antitoxin of type II toxin-antitoxin system. BrnA is family of antitoxins that neutralizes the toxin BrnT, pfam04365. It consists of 3 alpha-helices and a C-terminal ribbon-helix-helix DNA binding domain. As in other toxin-antitoxin systems, BrnA negatively autoregulates the brnTA operon and has higher affinity for the DNA operator when complexed with BrnT. It dimerizes with two molecules of its toxin BrnT.	0.00181035
NC_015578.1\|WP_015707448.1\|1389913_1393204_+\|cadherin-like-beta-sandwich-domain-containing-protein	gnl\|CDD\|378939	pfam12733, Cadherin-like, Cadherin-like beta sandwich domain. This domain is found in several bacterial, metazoan and chlorophyte algal proteins. A profile-profile comparison recovered the cadherin domain and a comparison of the predicted structure of this domain with the crystal structure of the cadherin showed a congruent seven stranded secondary structure. The domain is widespread in bacteria and seen in the firmicutes, actinobacteria, certain proteobacteria, bacteroides and chlamydiae with an expansion in Clostridium. In contrast, it is limited in its distribution in eukaryotes suggesting that it was derived through lateral transfer from bacteria. In prokaryotes, this domain is widely fused to other domains such as FNIII (Fibronectin Type III), TIG, SLH (S-layer homology), discoidin, cell-wall-binding repeat domain and alpha-amylase-like glycohydrolases. These associations are suggestive of a carbohydrate-binding function for this cadherin-like domain. In animal proteins it is associated with an ATP-grasp domain.	4.02797e-09
NC_015578.1\|WP_015707449.1\|1393219_1396744_+\|nuclease	gnl\|CDD\|379528	pfam14262, Cthe_2159, Carbohydrate-binding domain-containing protein Cthe_2159. Cthe_2159 from Clostridium thermocellum is the first representative of a novel family of cellulose and/or acid-sugar binding beta-helix proteins that share structural similarities with polysaccharide lyases.	5.34293e-08
NC_015578.1\|WP_015707437.1\|1373154_1373445_+\|antitoxin	gnl\|CDD\|227620	COG5304, COG5304, Uncharacterized protein conserved in bacteria [Function unknown].	4.60014e-14
NC_015578.1\|WP_041611047.1\|1403450_1404536_-\|DUF362-domain-containing-protein	gnl\|CDD\|377193	pfam04015, DUF362, Domain of unknown function (DUF362). Domain that is sometimes present in iron-sulphur proteins.	2.13334e-58
NC_015578.1\|WP_148257420.1\|1399362_1401744_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	4.65014e-11
NC_015578.1\|WP_041611044.1\|1376003_1376321_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|223713	COG0640, ArsR, Predicted transcriptional regulators [Transcription].	3.18012e-12
NC_015578.1\|WP_041611489.1\|1377656_1380140_+\|bifunctional-aspartate-kinase/homoserine-dehydrogenase-I	gnl\|CDD\|181856	PRK09436, thrA, bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional.	0
NC_015578.1\|WP_015707453.1\|1402806_1403109_+\|BrnT-family-toxin	gnl\|CDD\|367913	pfam04365, BrnT_toxin, Ribonuclease toxin, BrnT, of type II toxin-antitoxin system. BrnT is a ribonuclease toxin of a type II toxin-antitoxin system that exhibits a RelE-like fold. The antitoxin that neutralizes this toxin is pfam14384. BrnT is found in bacteria, archaea, bacteriophage, and plasmids. BrnT-BrnA forms a 2:2 tetrameric complex and autoregulates its own expression, which is induced by a number of different environmental stresses. Expression of BrnT alone results in cessation of bacterial growth which can be rescued after subsequent expression of BrnA.	6.74078e-27
NC_015578.1\|WP_015707441.1\|1376325_1377411_-\|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	gnl\|CDD\|133463	cd06853, GT_WecA_like, This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate molecule and N-acetylglucosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylglucosamine precursor. WecA participates in the biosynthesis of O antigen LPS in many enteric bacteria and is also involved in the biosynthesis of enterobacterial common antigen. A conserved short sequence motif and a conserved arginine at a cytosolic loop of this integral membrane protein were shown to be critical in recognition of substrate UDP-N-acetylglucosamine.	4.6436e-69
NC_015578.1\|WP_015707456.1\|1404661_1407202_+\|alpha-glucan-family-phosphorylase	gnl\|CDD\|340852	cd04299, GT35_Glycogen_Phosphorylase-like, proteins similar to glycogen phosphorylase. This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important allosteric enzymes in carbohydrate metabolism.	0
NC_015578.1\|WP_041611046.1\|1397339_1399262_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	9.60245e-08

>NC_015578.1|WP_015707446.1|1381368_1384683_+|cadherin-like-beta-sandwich-domain-containing-protein
MKAMRFFTLVCGVALIFAGCELFLNKPEKDALSGAEYEVWLAKAPHLSVRMELVPGSGSANPPTGLIVLPENRPKLEVPFNASFTVNPGFGFVEWQAYRAAAPGVKLGTEVQFRSLNASGTEVEVTALINEELIITPFCAALPGVTDHNLPNATFERLPTNYPVEIRFNAPIDPESLAFLNADNPQGTIAITGKADQGMNPTARDLTGQYDLQKDPAGLWIRLEPVRNGLSLSNNNITIELGTGIRRKDYPLFMVESRAFSYGAGDGPDLNFPVVDSNLIKGTLGLEEEDVFFPGKTISYDSAGRTWPEGYALKSDEEGTRTVYLLFDAYKSSAMIKEISITEERIMDIVGRAVTAEILPSPAYPNENLRNADSPLAWKYAQEFQKTPFVIPHTVQTAKEGVIRFYIQPRDSFGIGYSYVDAQTRGLYVEALLDLPPDPVTGIGGVYNRAAGTITLAWADPAQADLDYIDISWAGGTAKANAGEQKAVLTGIDSGLYNFTLSAVDRGGNRTTAEFAFNADSTIPSPVSDLQGSYNQASESMVLSWNNPVGDTEAETIRISWGGTAGGSATVALSGPSQGYAIPGIAPANGAAYTVTVKTANALKESGGVSVNIYPDITPPGPLTVGASYNQVSRTIAASWTDPADADLQEILLEWGINGEGIAGSQRIGRGQESYVITGVVSDSRGYTVRAYAIDRAGNQSAGKTLQVETDTTPPGAVWSLAGSYNREAQQITVTWTDPADPDLKEIRLAWQAGTGALTEITLEPGIKTYTIGQVGYNSGQYAITVTAADRAGNAGNAETVNVRTDSRPERLPAPTGVQVLPTGSADSKTLTIEWNAVSGATGYEVVYSIYNDSSTALPGGGTITDAASGKKTTTITGLSRASYYVWVRAKNALDAGEYNIAPAIGTPKYNVASLSNLVMSPVSISGFSPGTYTGYSVTIPSTSSSFTATGYPNFFGTVQYKFSGAFDSLNTWNISPGASGTVTVRVTAEDGSAQQDYTVAVSAAWSNPGGIVLPGEKITLSPTGPVNLSWAAAATQEFTVSSVSGATLTGIEWFVDGKKKTGAADKFTVTAKEYSLERPHTLTVRAKVDGLPYSLDAQFTVIR
>NC_015578.1|WP_015707445.1|1380685_1380934_+|hypothetical-protein
MARMTEEEAHALDEAITNADITLKPGKGGMFIRQRELLDALDRPSADYIMTRAMATNKMPLQILGELVHEQIIQNKEALAQG
>NC_015578.1|WP_015707444.1|1380424_1380676_+|hypothetical-protein
MFPNIEYNEAAFKHGVTETAIRYALWHPLHEQLLEAYKNKWLVIGYDTTGNLIEVAYNIIDDETVNVFHAMPCRKKFFGELTL
>NC_015578.1|WP_169313407.1|1380243_1380408_+|hypothetical-protein
MNKAGAGTFTLSAGTISANTERQRKKTGAVGRNAPGKKKALATRTPPKTCTTDN
>NC_015578.1|WP_041611489.1|1377656_1380140_+|bifunctional-aspartate-kinase/homoserine-dehydrogenase-I
MVVLKFGGTSVGSPEAIRKLIGILGDSEHAGKVRVVVVSALSGVTDSLIGLARQAAEGEVARAALKTLEERHRKISHAFLAGTERQETDAAIKASFAELSRTLDGIGILRELSPRSFDYVMSFGERLSAALLAHICTAQGVQAEYLDARPLVLTDGNYGSARYQGDESYSRIRSYLKKHPALQIATGFIGSNAEGHTTTLGRGGSDLSAAIFGAAMGAKCVEIWTDVDGILTADPKLVKTAFKIDSLSYNEAMELSHFGAKVLHPPTVRPALEKGIPIVIRNTFNPPGGGTRIADDADPGNYPIRGISSMGNVTLVRVQGSGMVGMTGFSARLFGALARKGISIILITQASSEYSICVVVAPQDGPLAAAVIGEEFEREIASGAIEAPAVMEDLAIIAVVGSNMEHTTGISGKVFHALGRNGINVVAIAQGSSEINISAVIGAQDVAKALNAIHEAFFLAGVRTVNLFLIGIGNIGGTLLDQITSHKETLADQYKIRINLVGVANSSRMIFNPAGLEPKKIRGVLSSGDIKQGSAGTELLPLTLPEFIRKMKSFNLPTTAFCDCTANPDVAAVYAEILQAAIPVVTPNKRANSGSLDYYKTITGYSRDRGIPYLYETTVCAGLPVISVLRDLALSGDKVRRIEAVLSGTLSFIFNNFDGSKTFSALVREAKAKGYTEPDPRDDLNAMDAARKALILARECGMSLEFPAVAIEPILPPSCFKANGVEAFFTELEKADADFEKRRLEAAKEGKVLRYVSIIEEGSARLSLRAESPGSPFLSLVDSDNIVVITTDRYSKLPMVIKGPGAGAQVTAGGVFADILRIARTLV
>NC_015578.1|WP_015707441.1|1376325_1377411_-|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase
MALGIITTTFVLSCTFVAIVLRLSRKKAWFDPIDERKIHTGEVPRLGGLGFATAFILVVFGIIFLVPALGIKLPNALLGPSFIFPLISIIIIFISGVFDDFHPMAPRYKLFIQFIAGILVLIPNYTFNRIFPFNIGSLGELIWLRYPITFLWIVGLTNAVNFIDGVDGLAGGVSALAALFYALIFMHSPNGGPTSLLALCLVAALGGFLVFNLPFPRARIFMGDGGSQFLGFTLALLPLSNGTGTGIPVFYAAALLSIPIFDTIAAIWRRLRDGRRIDSPDRLHIHHKLMNMGLSSRKVDAVLYGLQILLGVLVFESLRFKGGLSILLLGAAYAATAGFFTFIHFANRAIQKQLKTHTSET
>NC_015578.1|WP_041611044.1|1376003_1376321_+|helix-turn-helix-transcriptional-regulator
MDSQLACTEMAVVNEYSRKMKVCGHPVRLKLLCHIYRQGDPCVTNLWTSLGESQPVISQHLAILKENRVVDSVVQGNRRIYSICDDFIREVIAKMVAEVGEQGPC
>NC_015578.1|WP_015707439.1|1374709_1375864_-|aminotransferase-class-V-fold-PLP-dependent-enzyme
MRHYFDWAATALPLDLPSPSGSVPFGNPSSRHLEGRQARETLEAARSRCAAVLGVPPKQLYFSSGGTESNAIPLQSLLLRKNAAALVSSVEHPSVRENALVLKRLGATIMPIGVEKDGRVTESTLEAALAKIPTLRFAAIMGVNNETGAVMDLGALVKYIRQSSRQGPPVHVHSDLVQALGKIPLDISGWDLDSAAFSAHKIGGPRGVGLLWLRGTKGPQPLEVLGVGGGQEGGIRPGTENTAGALALAECMEAFATREAVEAGYAAATKRWKPLIQALRSMDRCTLIPEDRSDEDPRFSPWILQAGFRGIPGEVMARALDDAGFAVSTGSACSSREQKRPVLEAMGIGRDQSLEGVRFSQGWSTTIEEIEMLTRAIQKILEAL
>NC_015578.1|WP_015707438.1|1373528_1374710_-|tRNA-4-thiouridine(8)-synthase-ThiI
MAASESSLYLLKLGELTLKGGNRAGFEDILERNLRDLLRGTGAKILTTAGRFYVRTPQEGEARVEETLDRLMGISGWAKTRICEKSPQAVFAVCVAEGKALAAQGIESFKIEARRTDKSFPLDSYGIARGAGDAVSEAVPELRVDVRKPQGVITVEIRERAYIYGFSRQGRRGLPVGTAGRGLLLLSGGIDSPVAGYMMASRGMKIDAVYFHAYPYTSEEARQKVVKLAEIVGRFSLGIRLFTVGFTSLQMRIKEQAPEEWTTVLLRMAMMECAEKLAKHRRSKCLITGESLSQVASQTIENINCTGSRVKLPILRPLIGMDKESIIRAAVELGTYETSILPYPDCCVLFSPPHPVLRGDIGEANRLYEGLELGEMIDTAIRESVMERCSFPG
>NC_015578.1|WP_015707437.1|1373154_1373445_+|antitoxin
MKNINNKFLDDEEKDLAKSIANDEWQSIGNLDQMKRLLQEAARTTMTKDQRMNIRLTKKDLDGIKTRALAEGMPYQTLVSSIIHKYISGQLTEKEA
>NC_015578.1|WP_015707448.1|1389913_1393204_+|cadherin-like-beta-sandwich-domain-containing-protein
MKAARFFALACGAALIFAGCDLFLNKPEKDAISGAEYEVWLAKAPHLSVRMELVPGSGSANPPAGVIVLPDNRPKLEVPFNASFTVNPGFGFVEWQAYRAAAPGVKLGAEVQFRSLNASGTEVEVAAFINEELIIIPFCATLPGVTDHNLPNATFERLPTNYPVEIRFNTPIDPESLSFLTADNPQGTIAITGKADQGMTPTARDLTGQYDMQKDPSGLWIRLEPVRYGLALSNNNITIELGTGIRSRDYPIYMVESRALSYGAGDGPDLNFPVVDSRLIKGALGLEEDDVFFSGKTISYDNIGRVWPAGFLLKSDQAGQRTVYLFFDAYKTSAMIKDITITEERVMDIVGRAVTAEILPAPAYPNENLRNADSPLAWKYAQEFQKTPFVVAHTVQTVKEGVIRFYIQPRDSFGIGYSYADAQSRSLYVEALLDLPPDPVTGIGGVYNRIDGTITLTWADPANVDLDYIDISWAGGTAKAKAGEQRAVLADMVSGSYGFTIAAVDRGGNRSPAEEFAFNADSTIPSPVTGLSGYYNKDTQSMVLSWTNPQDPEVETIEISWAGMAAGATSIAKSGLSQGYAIPNILPANGAAYTVTVKTANTLKKSGGASVNIYPDITPPGPLTVGAFYDKGSRTIMLSWADPADTDLQEILLEWGISGAGIAGTERVGRGQGSYVITEAVSDSRGYTVRAYAFDRAGNQSAGKTLQVETDTTPPGAVWGLAGSYDREAQQITVAWTDPVDADLKEIRLGWQAENGALTTLTLGKGVGAYTINSVGYNSGEYSITVTAADQAGNAGKSETVNVRTDNRPATPGSIAAVNTLNSKELLVSWNKASGATGYDLRYGLSSSGSGAVVVGIDGGTTLSKTLSGLSDGAAYYVWVRAKDGTVLGDYNTTPVTGTPKNNNAALGSLSIKGAALSPAFAADTTKYTAILPAGSSEVTVDAAAEDSNAAVSYGFDGGFLSSAANFKTINPGAVVQARVSVTAQNGATTKTYTITVTRLQQADIVIGGPQNPISVSPETAKISWRGGAKAFTVKGTGPRDAIQWYVDGVPKRDATGDSVTIVASDYLATEHTLMVKVITAAGVLYTRELKFTVTQ
>NC_015578.1|WP_015707449.1|1393219_1396744_+|nuclease
MNIYGKNGTKIAIVLAALLAAGLILGSCANALGPENTPVLESATQFPAQGMGRLQISLELPSDTDLPSRTIFPENQFTRYELSFAETGGPGAYTHGDEELTSARASVDLPPGTWTITVKAYAGAERDILSGTGTATNVVVSAGSAASAPITLGRYTESAVSGKLSWNITLPSGGTYADNTLTALAKDGNNLTAGLFADPINLSDQSSLLDLDGKEIAPGEYLVKLSIKSAAGPVATWLESVHIYPGQTTHISPIFSAEAFSVQVPVYGVVTSTGSLSFTSKTVEAFSEADYTARNFNAPLDVSVVDAQGYVLFIPATVPKVYLRLTALVDSKIIYKVYPDALLVGAAAGPRNKPLPAAAYGITTNTPENGTITAPSAAFEGEPVAVTVEPDPNYLLQGGSLTYNSTAFTDTFTMPGEAITITATFLSSSGMAASVNGAAYDTLSKAFDAVNRAETGSLLAGTQSKPVVITLLKNADIGAAANCITLDTGRYVQLISNNSSGLTIKLTTNDVGSIFTVATGAGLTLGDGINPLTLDGGAASTPICTNTDALVTVTGSLTIKAGAIVQNNRNTTATTSAYGGGVRVNGTGTMLLEGTIKQNSSDSGGGIYLDAGSALTIQGSAQVFSNNEVYLAATSAKISMGDSLTQAAVAVIKPAVYADWETTPLITGDVNLFADHYTQFTVSPEPSHNWKISPNATPVGALMDAQFIVTYNTRLIGYYKTLATALSGITAAGSAGSINEPIIITMYTNTSLASDGDAMTISGDSFIQLIPGNQDGVTISRAYSSSTKPVFTVAAGSRLTLGVDGGTIPLIIDGTSKTTTAALIGVVGTLIMNGGTIRGNTGSTTANGGGVYMTNGTFTMNGGTISGNRFNNGGGVYMTSGTFTMNGGTITDNSSNSKGGGVYVAGGIFTMTGGIISGNRSSSDGGGVYVDGGTFTMGVGGETITGNTAYKGGGGVYVTGDKTFTMNGGTITVNNGSDGGGVYASTDFAMNGGIITANDGVSGGGVYTSKSFTLNTGAITGNNGFDGAGVYVNAGDFNIKGGTINRNRADNNGGGVYMSGGNSEMRLGEIRDNTCNNDGGGVFISYGARFSMVTGTFNRNRAGNDGGGVYVAGVFAWDVGQGSGTIAADQIAGRFGKVMYKTQYGTAKYSQVLDIPLEGINTPDKYRDFVLPPV
>NC_015578.1|WP_015707450.1|1396873_1397287_+|hypothetical-protein
MKRALFLSTVLIFTLAGLAFGADTFTVKSFSGKVDQLEPSGQWVSVSVGGTLSASTTVKLGLNSILVVVQGDQESTIRAARQGTLESLLSAGTGGGKISVGGTVTNSTVEGNAQGVSNIPTATSRAGDTAADLDWVK
>NC_015578.1|WP_041611046.1|1397339_1399262_+|tetratricopeptide-repeat-protein
MISRQYKAIFFLLFLAFGRFARLPALDFTLRPRPFLLIPQGEVADLYAMGYGGDLLFDLDVSSILTNPWGLGYSLGLEGAFIYADLAQGAEGDIQIYSAGAGARLFGYPLSRLALSLDGAFGLSQAIQHYGHQEDGSAASWYWRAGAEAGFRFAPFFTFALNGGYRYYHNERRDGALYQGLYAGLTFQFTLSTKKAAGLRLELIQEEPVYPLFLSLYQRNGAGTLRISNYETAEIRNVRVSFRAGQYTSSEISCGNIGFIGRGRHAELPLYADFSPALLNFTEDGRILGEVVIRYTFLGSERTAVISSTVRVVNRNAYRWGDNASLAAFVSPTAPAPLEYAKYVVGLARSKRRTGLNQNMQFSLWLYEGLLTAGLRQSAGSNRVTDIDSIQFPSETLAFRSGNAVDIGLLYANTLESSGIPAAIIPLEDDFMVLYSLGISQAAADSLFTNIENLLVINDEMWMPLSMANFNNGFMNSWEGGSKRLNQAFEAGEALDFIRFADAWAAYPPVVPPVEAQSARPEEGALNRRVDTAFGIYIATELEPKIGALEAQLGANPGAASFNQLGLLLLRANRPEDAKPVFEQAASYGSAAGMVNRGNLSLLDKDFTGAEAWFTQALGLNPENAAAKNGLAQMALQRGE
>NC_015578.1|WP_148257420.1|1399362_1401744_+|tetratricopeptide-repeat-protein
MFPVLIAFLLLSAAAAYGENSIALRLSPGAAIPLGDSVFVPGFGAAGLAEWAFSLKPQSRFFSGLRLGGGFFQIAVETGSPIVFTQGKLGLFFQWRALDRLSLWVEGNGGIFTYNYSWDDTADTRLRLGGSLGADFHLTPAIALYAAADYNWHSITPDSSLTTLGINLGVRLDLLELLRKETRVAGEKKTQESVFPVSYAWYENNPLASVRVTNQEPTAINDVQLSFYLERYMGQPTLFYTIPLLKPGESVEVPVTALFNEAMMDLTENITANASLRIDYRALSQVKQAELPLQMPIYHRNAMSWDDDRRAASFVSSQDPAAKFFARHVQSITDTRLRPFKGSPERIPRNIQYALGLFEALKVYGINYVIDPSSSYIELSENASSLDTLNYPYQTLYYRGGDCDDLSILFCSMLEVLGIDTAFITIPGHIYMAFDSGLTEEEGREQFFLPDDLIYQGGKAWVPLEITQTAAPFYQAWRTGAQEWRDAGSEGSFFPMQESWARYKPVSVSDAADKMPELPDEDSLIDAIEESLNIYAGFLIRPRTRELEGQIAASSSGIAMVRRNDLGGLYGKTGMLLNAETELSRIPSNAPVALNLGNIAFVRGHYDDAESLYRESLEREPENILARLGLARTCYEQGDYAGAEREYRYLQEANPELAEQYPYLGIWRETLGQPLSYSDRLVTTLWMDAQWQLETNRIAAEAAETEWLTEAEQTAVEQEEESPALAAFYRVVYGDSLVRIAQRGYIYGDWKQWRRIYEANKAAFPRRGDPDFILPGMILRIPSINGEKRSGTW
>NC_015578.1|WP_041611490.1|1401777_1402614_-|epoxyqueuosine-reductase
MENGDFIALIRDQVKTSSGNRLKPEAALRPELAGMPFFEEPVLGFAAADDPYFGELKKPGVIGDHFLLPREWLSGARTVVSVFFPHSEAVKKANRQTMEWPADEWLQARIEGQAFIEELCRYTAAFLKDSGFSCAIPCFDPRFKTGNPAIRDNTRQDFYTSNWSERHVAHVCGLGTFGLSRGLITPKGISGRLASFISDAQFAPTVRPYSGISDYCTRCGACVRNCPAGAITLEEGKNHPLCSAFLDRTKEKHRPRYGCGKCQSAVPCESGIPAMGHS
>NC_015578.1|WP_015707453.1|1402806_1403109_+|BrnT-family-toxin
MNFEWDSEKDVKNVKIHKLSFSTAKLVFNDPERMERFDRNHSDHEARYQTLGMVDEVLFVVYTERDDITRIISARLADKDERRIYYGNSKGDFAGWTKAD
>NC_015578.1|WP_015707454.1|1403062_1403377_+|hypothetical-protein
MAIVRETLQGGQKPTKEQIDEIRNAAKYPVVYNEVSPKLTAGELAEFRRVSEINAAERERVMCSIRLQKRTLDWWKSLGEGYTAVMARLLDEARNYPDLIKKCL
>NC_015578.1|WP_041611047.1|1403450_1404536_-|DUF362-domain-containing-protein
MEKNEILVIYGKKIEEMAFSLAEAADLADLIRDRDRRIGLKPNLVVARPAADGATTHPEIARGLIRYLQKNGFQNLVILEGSWVGARTGEAFPCCGYTKLAQETGVELIDTQLDSSKPYDCKGMKIEICDSAMGVDFMINLPVMKGHCQTLMTCALKNNKGIMPDKEKRRFHTLGLDKPIAHLNTVAKNDFILVDGICGDLDFEEGGNPVYSGKLYAARDPVLCDAWTASQMGYRPEEIPYIGLAEGLGVGCGDPAKAVIRELSPPSSAIETTPSGKARQYASFIEEDQACSACYANLIFALSRMNHNELNRIKGKICIGQGFKGKPGKLGIGRCTLSCDASLKGCPPGGADIIAFLQKQV
>NC_015578.1|WP_015707456.1|1404661_1407202_+|alpha-glucan-family-phosphorylase
MNISTYTIKPKLPNSLKPLEELARNLWLSWNFDAVQLYIRLDYDVWLQSQQSPVRTLGMVSQERLAEVAKDDSYLSALNEVYGRFLKYKKGETWYRGSRKDVVAYFSMEYGMDVSLPIYSGGLGMLSGDHMKTSSDMGLPLVGIGLLYRQGYFKQYLNADGFQQETYPENDWYNMPVERKNDKNGNPLKISVDLAGRVAVAQIWEVKVGRSFLYLLDTNIEENAQDFRNITSALYGGDKETRIQQEILLGIGGIRALRALGINPAATHMNEGHAAFLGLERVREIMVEKHFNFDEAREVVWPTNIFTTHTPVPAGNERFDIGLIEKYFRPWTQTLGISWKDFLGLGRERVYDDHEPFCMTVLALKMAAYANGVSKLHGEVSRIMWKGLWPNLPLEEIPISHVTNGVHPRTWVSNNMTDLLDRYFGTHFNDEPTDLAIWDRMDRISDEELWRTHERRRERLVAFARDRIRQNLKRNGAVERRIQKAEDALSPYVLTLAFARRFATYKRGNLLLRDPDRLLRLLRDKDRPIQLIFAGKAHPMDMPGKELIKEIIHFAEHHDVESRIIFLENYDMTMGHYLTAGADVWLNTPRRPLEASGTSGMKASMNGVLNCSILDGWWDEAYNPEVGWAIGRGEEYEDTKLQDEVESKALYDLLEREIIPLFYQRGRDGLPREWIKMMKTCMKEIGHSMSSHRMLMDYSNKFYFPALKNYRRLVKDDYTEAKSLAAYMTKLHQSWDSLKINKVESNSKPVMQRGDSLTVSATIELGALKPEDVLVELYHGTVSNQGNDITNARRTEMKPLGQQGNSYQYQVRIECADTGQQGHTVRILPKHEALVHPYRTGLIKWA

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Crispr_ID: NC_015578_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015578_7

1395991-1396549

Orphan

Consensus_repeat	Method
CGGCGGCGGGGTGTAT	PILER-CR

7 spacers

The CRISPR arrays of NC_015578_7

>merge|NC_015578|7|1395991-1396549|PILER-CR
CGGCGGCGGGGTGTATGTGGACGGCGGGACCTTCACCATGGGCGTGGGAGGGGAAACTATCACCGGCAACACCGCCTACAAGGGCGGCGGCGGGGTGTATGTGACCGGCGATAAGACCTTCACCATGAACGGGGGAACCATCACCGTCAACAACGGCTCCGACGGCGGCGGGGTGTATGCGAGTACGGACTTCGCCATGAACGGGGGAATTATCACCGCCAACGATGGCGTCAGCGGCGGCGGAGTGTATACGAGCAAGAGCTTCACCTTGAATACGGGAGCCATCACCGGCAACAACGGCTTCGACGGCGCCGGGGTGTATGTGAACGCCGGGGACTTCAACATAAAAGGGGGAACCATCAACCGCAATAGAGCAGACAACAACGGCGGCGGGGTGTATATGAGCGGAGGGAACTCCGAAATGAGATTGGGAGAAATCCGCGACAATACCTGCAACAACGACGGCGGCGGGGTGTTTATTAGTTACGGTGCACGCTTCAGCATGGTCACTGGAACCTTCAACCGCAATAGAGCAGGCAACGACGGCGGCGGGGTGTAT

>NC_015578|7|2|1395991-1396549|PILER-CR
CGGCGGCGGGGTGTAT	GTGGACGGCGGGACCTTCACCATGGGCGTGGGAGGGGAAACTATCACCGGCAACACCGCCTACAAGGG
CGGCGGCGGGGTGTAT	GTGACCGGCGATAAGACCTTCACCATGAACGGGGGAACCATCACCGTCAACAACGGCTCCGA
CGGCGGCGGGGTGTAT	GCGAGTACGGACTTCGCCATGAACGGGGGAATTATCACCGCCAACGATGGCGTCAG
CGGCGGCGGAGTGTAT	ACGAGCAAGAGCTTCACCTTGAATACGGGAGCCATCACCGGCAACAACGGCTTCGA
CGGCGCCGGGGTGTAT	GTGAACGCCGGGGACTTCAACATAAAAGGGGGAACCATCAACCGCAATAGAGCAGACAACAA
CGGCGGCGGGGTGTAT	ATGAGCGGAGGGAACTCCGAAATGAGATTGGGAGAAATCCGCGACAATACCTGCAACAACGA
CGGCGGCGGGGTGTTT	ATTAGTTACGGTGCACGCTTCAGCATGGTCACTGGAACCTTCAACCGCAATAGAGCAGGCAACGA
CGGCGGCGGGGTGTAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_015578.1\|WP_015707439.1\|1374709_1375864_-\|aminotransferase-class-V-fold-PLP-dependent-enzyme	unknown	unknown	gnl\|CDD\|224029
NC_015578.1\|WP_015707447.1\|1384697_1389701_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380183
NC_015578.1\|WP_041611490.1\|1401777_1402614_-\|epoxyqueuosine-reductase	unknown	unknown	gnl\|CDD\|224516
NC_015578.1\|WP_169313407.1\|1380243_1380408_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_041611049.1\|1408430_1408838_-\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350259
NC_015578.1\|WP_015707444.1\|1380424_1380676_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015707454.1\|1403062_1403377_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|373040
NC_015578.1\|WP_015707446.1\|1381368_1384683_+\|cadherin-like-beta-sandwich-domain-containing-protein	unknown	unknown	gnl\|CDD\|238020
NC_015578.1\|WP_015707445.1\|1380685_1380934_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015707448.1\|1389913_1393204_+\|cadherin-like-beta-sandwich-domain-containing-protein	unknown	unknown	gnl\|CDD\|378939
NC_015578.1\|WP_041611491.1\|1407719_1408364_+\|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223728
NC_015578.1\|WP_015707450.1\|1396873_1397287_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_148257420.1\|1399362_1401744_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NC_015578.1\|WP_041611047.1\|1403450_1404536_-\|DUF362-domain-containing-protein	unknown	unknown	gnl\|CDD\|377193
NC_015578.1\|WP_041611044.1\|1376003_1376321_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223713
NC_015578.1\|WP_041611489.1\|1377656_1380140_+\|bifunctional-aspartate-kinase/homoserine-dehydrogenase-I	unknown	unknown	gnl\|CDD\|181856
NC_015578.1\|WP_015707453.1\|1402806_1403109_+\|BrnT-family-toxin	unknown	unknown	gnl\|CDD\|367913
NC_015578.1\|WP_015707441.1\|1376325_1377411_-\|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	unknown	unknown	gnl\|CDD\|133463
NC_015578.1\|WP_015707456.1\|1404661_1407202_+\|alpha-glucan-family-phosphorylase	unknown	unknown	gnl\|CDD\|340852
NC_015578.1\|WP_041611046.1\|1397339_1399262_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809

Protein	Function_ID	Function_description	E-value
NC_015578.1\|WP_015707439.1\|1374709_1375864_-\|aminotransferase-class-V-fold-PLP-dependent-enzyme	gnl\|CDD\|224029	COG1104, NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism].	8.22539e-104
NC_015578.1\|WP_015707447.1\|1384697_1389701_+\|hypothetical-protein	gnl\|CDD\|380183	NF033176, auto_AIDA-I, autotransporter adhesin AIDA-I.	9.00136e-09
NC_015578.1\|WP_041611490.1\|1401777_1402614_-\|epoxyqueuosine-reductase	gnl\|CDD\|224516	COG1600, COG1600, Uncharacterized Fe-S protein [Energy production and conversion].	2.33755e-19
NC_015578.1\|WP_041611049.1\|1408430_1408838_-\|PIN-domain-containing-protein	gnl\|CDD\|350259	cd18692, PIN_VapC-like, uncharacterized subfamily of the VapC-like nuclease family of the PIN domain superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include FitB toxin of the FitAB TA system, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	2.78261e-53
NC_015578.1\|WP_015707446.1\|1381368_1384683_+\|cadherin-like-beta-sandwich-domain-containing-protein	gnl\|CDD\|238020	cd00063, FN3, Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.	0.00667472
NC_015578.1\|WP_015707454.1\|1403062_1403377_+\|hypothetical-protein	gnl\|CDD\|373040	pfam14384, BrnA_antitoxin, BrnA antitoxin of type II toxin-antitoxin system. BrnA is family of antitoxins that neutralizes the toxin BrnT, pfam04365. It consists of 3 alpha-helices and a C-terminal ribbon-helix-helix DNA binding domain. As in other toxin-antitoxin systems, BrnA negatively autoregulates the brnTA operon and has higher affinity for the DNA operator when complexed with BrnT. It dimerizes with two molecules of its toxin BrnT.	0.00181035
NC_015578.1\|WP_015707448.1\|1389913_1393204_+\|cadherin-like-beta-sandwich-domain-containing-protein	gnl\|CDD\|378939	pfam12733, Cadherin-like, Cadherin-like beta sandwich domain. This domain is found in several bacterial, metazoan and chlorophyte algal proteins. A profile-profile comparison recovered the cadherin domain and a comparison of the predicted structure of this domain with the crystal structure of the cadherin showed a congruent seven stranded secondary structure. The domain is widespread in bacteria and seen in the firmicutes, actinobacteria, certain proteobacteria, bacteroides and chlamydiae with an expansion in Clostridium. In contrast, it is limited in its distribution in eukaryotes suggesting that it was derived through lateral transfer from bacteria. In prokaryotes, this domain is widely fused to other domains such as FNIII (Fibronectin Type III), TIG, SLH (S-layer homology), discoidin, cell-wall-binding repeat domain and alpha-amylase-like glycohydrolases. These associations are suggestive of a carbohydrate-binding function for this cadherin-like domain. In animal proteins it is associated with an ATP-grasp domain.	4.02797e-09
NC_015578.1\|WP_041611491.1\|1407719_1408364_+\|NAD(P)H-dependent-oxidoreductase	gnl\|CDD\|223728	COG0655, WrbA, Multimeric flavodoxin WrbA [General function prediction only].	8.38253e-17
NC_015578.1\|WP_041611047.1\|1403450_1404536_-\|DUF362-domain-containing-protein	gnl\|CDD\|377193	pfam04015, DUF362, Domain of unknown function (DUF362). Domain that is sometimes present in iron-sulphur proteins.	2.13334e-58
NC_015578.1\|WP_148257420.1\|1399362_1401744_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	4.65014e-11
NC_015578.1\|WP_041611044.1\|1376003_1376321_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|223713	COG0640, ArsR, Predicted transcriptional regulators [Transcription].	3.18012e-12
NC_015578.1\|WP_041611489.1\|1377656_1380140_+\|bifunctional-aspartate-kinase/homoserine-dehydrogenase-I	gnl\|CDD\|181856	PRK09436, thrA, bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional.	0
NC_015578.1\|WP_015707453.1\|1402806_1403109_+\|BrnT-family-toxin	gnl\|CDD\|367913	pfam04365, BrnT_toxin, Ribonuclease toxin, BrnT, of type II toxin-antitoxin system. BrnT is a ribonuclease toxin of a type II toxin-antitoxin system that exhibits a RelE-like fold. The antitoxin that neutralizes this toxin is pfam14384. BrnT is found in bacteria, archaea, bacteriophage, and plasmids. BrnT-BrnA forms a 2:2 tetrameric complex and autoregulates its own expression, which is induced by a number of different environmental stresses. Expression of BrnT alone results in cessation of bacterial growth which can be rescued after subsequent expression of BrnA.	6.74078e-27
NC_015578.1\|WP_015707441.1\|1376325_1377411_-\|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	gnl\|CDD\|133463	cd06853, GT_WecA_like, This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate molecule and N-acetylglucosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylglucosamine precursor. WecA participates in the biosynthesis of O antigen LPS in many enteric bacteria and is also involved in the biosynthesis of enterobacterial common antigen. A conserved short sequence motif and a conserved arginine at a cytosolic loop of this integral membrane protein were shown to be critical in recognition of substrate UDP-N-acetylglucosamine.	4.6436e-69
NC_015578.1\|WP_015707456.1\|1404661_1407202_+\|alpha-glucan-family-phosphorylase	gnl\|CDD\|340852	cd04299, GT35_Glycogen_Phosphorylase-like, proteins similar to glycogen phosphorylase. This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important allosteric enzymes in carbohydrate metabolism.	0
NC_015578.1\|WP_041611046.1\|1397339_1399262_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	9.60245e-08

>NC_015578.1|WP_015707448.1|1389913_1393204_+|cadherin-like-beta-sandwich-domain-containing-protein
MKAARFFALACGAALIFAGCDLFLNKPEKDAISGAEYEVWLAKAPHLSVRMELVPGSGSANPPAGVIVLPDNRPKLEVPFNASFTVNPGFGFVEWQAYRAAAPGVKLGAEVQFRSLNASGTEVEVAAFINEELIIIPFCATLPGVTDHNLPNATFERLPTNYPVEIRFNTPIDPESLSFLTADNPQGTIAITGKADQGMTPTARDLTGQYDMQKDPSGLWIRLEPVRYGLALSNNNITIELGTGIRSRDYPIYMVESRALSYGAGDGPDLNFPVVDSRLIKGALGLEEDDVFFSGKTISYDNIGRVWPAGFLLKSDQAGQRTVYLFFDAYKTSAMIKDITITEERVMDIVGRAVTAEILPAPAYPNENLRNADSPLAWKYAQEFQKTPFVVAHTVQTVKEGVIRFYIQPRDSFGIGYSYADAQSRSLYVEALLDLPPDPVTGIGGVYNRIDGTITLTWADPANVDLDYIDISWAGGTAKAKAGEQRAVLADMVSGSYGFTIAAVDRGGNRSPAEEFAFNADSTIPSPVTGLSGYYNKDTQSMVLSWTNPQDPEVETIEISWAGMAAGATSIAKSGLSQGYAIPNILPANGAAYTVTVKTANTLKKSGGASVNIYPDITPPGPLTVGAFYDKGSRTIMLSWADPADTDLQEILLEWGISGAGIAGTERVGRGQGSYVITEAVSDSRGYTVRAYAFDRAGNQSAGKTLQVETDTTPPGAVWGLAGSYDREAQQITVAWTDPVDADLKEIRLGWQAENGALTTLTLGKGVGAYTINSVGYNSGEYSITVTAADQAGNAGKSETVNVRTDNRPATPGSIAAVNTLNSKELLVSWNKASGATGYDLRYGLSSSGSGAVVVGIDGGTTLSKTLSGLSDGAAYYVWVRAKDGTVLGDYNTTPVTGTPKNNNAALGSLSIKGAALSPAFAADTTKYTAILPAGSSEVTVDAAAEDSNAAVSYGFDGGFLSSAANFKTINPGAVVQARVSVTAQNGATTKTYTITVTRLQQADIVIGGPQNPISVSPETAKISWRGGAKAFTVKGTGPRDAIQWYVDGVPKRDATGDSVTIVASDYLATEHTLMVKVITAAGVLYTRELKFTVTQ
>NC_015578.1|WP_015707447.1|1384697_1389701_+|hypothetical-protein
MKNIRKTMQTVSLLSALAAALLLGSCANPFAPDKPNPEYKPSPDTTIPQGYGRLLVSLGLEEPAELAVAQQEAPEAALQAARTLIPGAFTRYEVTFTNKDDPPVVVTKTWTTPTGNVVDLIPGTWTIAVTAYAGTGTGAVASGTGQLTNVAVTAAAAAEISIPLSMKAGGSGTLSYTITFPGTLSSYTTRKLTIYNDNGEPISSLPAENPSTTNPITFTTSPATGTVSLNAGGYYLVAELENSQGRFARWTTAFHIYNGQTTPAAHSFGDGDFEESIPVSGTATLTVGMGITLSEVTVSAYGTAACDGLPVAGPVALASVTTGGTYTLFIPNRYAAVWLRLGAKDSADQPVSGAEASVTEVPINEDPVTQNLSAGIYAITPYAADGGKVTAPSAAFKGSTVAVTVSPAPGYFQSGKSQYTDSASITMSFDGGTFTMPALNVTLSANFALIATGGETDVAIVNNVGYDNLNAAFAAVPAGTGTAASPVVITVLKSTVTVTETITVDGGRYVQLVGAGYTTATITFNENTFLEVKAGAGLILGDGTLPIALDGDARWTNFDTGEHAGVSRGGALVRTAGAFTIKGSARVQNNYGGTTGEGGGVYVAEATGNLVVDGGAIENNWASKGGGVYLSGAGADLTVTQYGSISGNAAETGGGVYLSGAGAALTVTQYGSISGNAAETGGGVYAAGGNSTLQDGGSVEGNLAQDGGGVYLVAVETGIGPRLNIRVGGAVKANQASRNGGGVYVGKKANLTMTETSVIGNSPTETDAGNSATVGGGGLYLAVDATASLEGKARITGNTAPTGKGPDAALAATLNLNGGALVSDAYLINATGAIGVPGILTATVSAKITPHDYDRNQPVLTGVNVAANYTRFTLANPTADGNNYMIRRTGSLVNARYTRYRNATTVDYYTTLGDLLYDDGFPSESSSEDPPDEIRIASGTSSITLGAGEGFTIPAGVHVKLVPPSEGFTISRNAASSTPVFTVNTGTSLAIGGTTYALTLDGGSSTHTSPLVQVNGGTFTMGNIATLKNNKRSGDGGAVSVASGTFTMSGGTIGGTSSTKNTATYGGAVSVSSGGSFTMSGGSITGNTATANGGAVSVSGGTFTLSGGTITANTATANGGAVSVTAGLFTLSGGTIGGSSSDKNTATYGGGVYVSSSGEFKLSTGTISYNTATYGGGVSVSGGSFTLSGGTITANTATANGGGVSVSGGSFTLNTPSSQVSITANSADNGGAVSVTGGTFALNGGIIGGSSSNRNTAVNGGGVYVYGGAFNLTSGSISYNTATTNGGGVYMNISNPLTLSNGSIHDNTATNGGGVYKTGSGTFTMNGGTLSITNNTATGSETNGGGVYVANGKFELIAGSIGGNTATNGGGVSVASEGTFTMTGGTIGSTRNTATDKGGGVYARGPFTMSAGTISSNTAKDGGGVYATTSPFTMSNTASISSNTATNDGGGVYASNFTLNAGTISNNTATNNGGGVFKAGYDTFTMNGGTIGGSSSSANNTAAMGAGVYVDAAEFELKAGTISYNTATTRGGGVYVKTFATLTMSGSGGTISNNSVSGIGSGGGVFVDASATFTMSAGAISNNAMTHTSVGPCYGGGVAVTGIFYMSGGTISNNTNSSITGLGNNLFKGPDAIAMYGTADTPSSTWIAGSSGNAGYTNDTLPVPGAL
>NC_015578.1|WP_015707446.1|1381368_1384683_+|cadherin-like-beta-sandwich-domain-containing-protein
MKAMRFFTLVCGVALIFAGCELFLNKPEKDALSGAEYEVWLAKAPHLSVRMELVPGSGSANPPTGLIVLPENRPKLEVPFNASFTVNPGFGFVEWQAYRAAAPGVKLGTEVQFRSLNASGTEVEVTALINEELIITPFCAALPGVTDHNLPNATFERLPTNYPVEIRFNAPIDPESLAFLNADNPQGTIAITGKADQGMNPTARDLTGQYDLQKDPAGLWIRLEPVRNGLSLSNNNITIELGTGIRRKDYPLFMVESRAFSYGAGDGPDLNFPVVDSNLIKGTLGLEEEDVFFPGKTISYDSAGRTWPEGYALKSDEEGTRTVYLLFDAYKSSAMIKEISITEERIMDIVGRAVTAEILPSPAYPNENLRNADSPLAWKYAQEFQKTPFVIPHTVQTAKEGVIRFYIQPRDSFGIGYSYVDAQTRGLYVEALLDLPPDPVTGIGGVYNRAAGTITLAWADPAQADLDYIDISWAGGTAKANAGEQKAVLTGIDSGLYNFTLSAVDRGGNRTTAEFAFNADSTIPSPVSDLQGSYNQASESMVLSWNNPVGDTEAETIRISWGGTAGGSATVALSGPSQGYAIPGIAPANGAAYTVTVKTANALKESGGVSVNIYPDITPPGPLTVGASYNQVSRTIAASWTDPADADLQEILLEWGINGEGIAGSQRIGRGQESYVITGVVSDSRGYTVRAYAIDRAGNQSAGKTLQVETDTTPPGAVWSLAGSYNREAQQITVTWTDPADPDLKEIRLAWQAGTGALTEITLEPGIKTYTIGQVGYNSGQYAITVTAADRAGNAGNAETVNVRTDSRPERLPAPTGVQVLPTGSADSKTLTIEWNAVSGATGYEVVYSIYNDSSTALPGGGTITDAASGKKTTTITGLSRASYYVWVRAKNALDAGEYNIAPAIGTPKYNVASLSNLVMSPVSISGFSPGTYTGYSVTIPSTSSSFTATGYPNFFGTVQYKFSGAFDSLNTWNISPGASGTVTVRVTAEDGSAQQDYTVAVSAAWSNPGGIVLPGEKITLSPTGPVNLSWAAAATQEFTVSSVSGATLTGIEWFVDGKKKTGAADKFTVTAKEYSLERPHTLTVRAKVDGLPYSLDAQFTVIR
>NC_015578.1|WP_015707445.1|1380685_1380934_+|hypothetical-protein
MARMTEEEAHALDEAITNADITLKPGKGGMFIRQRELLDALDRPSADYIMTRAMATNKMPLQILGELVHEQIIQNKEALAQG
>NC_015578.1|WP_015707444.1|1380424_1380676_+|hypothetical-protein
MFPNIEYNEAAFKHGVTETAIRYALWHPLHEQLLEAYKNKWLVIGYDTTGNLIEVAYNIIDDETVNVFHAMPCRKKFFGELTL
>NC_015578.1|WP_169313407.1|1380243_1380408_+|hypothetical-protein
MNKAGAGTFTLSAGTISANTERQRKKTGAVGRNAPGKKKALATRTPPKTCTTDN
>NC_015578.1|WP_041611489.1|1377656_1380140_+|bifunctional-aspartate-kinase/homoserine-dehydrogenase-I
MVVLKFGGTSVGSPEAIRKLIGILGDSEHAGKVRVVVVSALSGVTDSLIGLARQAAEGEVARAALKTLEERHRKISHAFLAGTERQETDAAIKASFAELSRTLDGIGILRELSPRSFDYVMSFGERLSAALLAHICTAQGVQAEYLDARPLVLTDGNYGSARYQGDESYSRIRSYLKKHPALQIATGFIGSNAEGHTTTLGRGGSDLSAAIFGAAMGAKCVEIWTDVDGILTADPKLVKTAFKIDSLSYNEAMELSHFGAKVLHPPTVRPALEKGIPIVIRNTFNPPGGGTRIADDADPGNYPIRGISSMGNVTLVRVQGSGMVGMTGFSARLFGALARKGISIILITQASSEYSICVVVAPQDGPLAAAVIGEEFEREIASGAIEAPAVMEDLAIIAVVGSNMEHTTGISGKVFHALGRNGINVVAIAQGSSEINISAVIGAQDVAKALNAIHEAFFLAGVRTVNLFLIGIGNIGGTLLDQITSHKETLADQYKIRINLVGVANSSRMIFNPAGLEPKKIRGVLSSGDIKQGSAGTELLPLTLPEFIRKMKSFNLPTTAFCDCTANPDVAAVYAEILQAAIPVVTPNKRANSGSLDYYKTITGYSRDRGIPYLYETTVCAGLPVISVLRDLALSGDKVRRIEAVLSGTLSFIFNNFDGSKTFSALVREAKAKGYTEPDPRDDLNAMDAARKALILARECGMSLEFPAVAIEPILPPSCFKANGVEAFFTELEKADADFEKRRLEAAKEGKVLRYVSIIEEGSARLSLRAESPGSPFLSLVDSDNIVVITTDRYSKLPMVIKGPGAGAQVTAGGVFADILRIARTLV
>NC_015578.1|WP_015707441.1|1376325_1377411_-|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase
MALGIITTTFVLSCTFVAIVLRLSRKKAWFDPIDERKIHTGEVPRLGGLGFATAFILVVFGIIFLVPALGIKLPNALLGPSFIFPLISIIIIFISGVFDDFHPMAPRYKLFIQFIAGILVLIPNYTFNRIFPFNIGSLGELIWLRYPITFLWIVGLTNAVNFIDGVDGLAGGVSALAALFYALIFMHSPNGGPTSLLALCLVAALGGFLVFNLPFPRARIFMGDGGSQFLGFTLALLPLSNGTGTGIPVFYAAALLSIPIFDTIAAIWRRLRDGRRIDSPDRLHIHHKLMNMGLSSRKVDAVLYGLQILLGVLVFESLRFKGGLSILLLGAAYAATAGFFTFIHFANRAIQKQLKTHTSET
>NC_015578.1|WP_041611044.1|1376003_1376321_+|helix-turn-helix-transcriptional-regulator
MDSQLACTEMAVVNEYSRKMKVCGHPVRLKLLCHIYRQGDPCVTNLWTSLGESQPVISQHLAILKENRVVDSVVQGNRRIYSICDDFIREVIAKMVAEVGEQGPC
>NC_015578.1|WP_015707439.1|1374709_1375864_-|aminotransferase-class-V-fold-PLP-dependent-enzyme
MRHYFDWAATALPLDLPSPSGSVPFGNPSSRHLEGRQARETLEAARSRCAAVLGVPPKQLYFSSGGTESNAIPLQSLLLRKNAAALVSSVEHPSVRENALVLKRLGATIMPIGVEKDGRVTESTLEAALAKIPTLRFAAIMGVNNETGAVMDLGALVKYIRQSSRQGPPVHVHSDLVQALGKIPLDISGWDLDSAAFSAHKIGGPRGVGLLWLRGTKGPQPLEVLGVGGGQEGGIRPGTENTAGALALAECMEAFATREAVEAGYAAATKRWKPLIQALRSMDRCTLIPEDRSDEDPRFSPWILQAGFRGIPGEVMARALDDAGFAVSTGSACSSREQKRPVLEAMGIGRDQSLEGVRFSQGWSTTIEEIEMLTRAIQKILEAL
>NC_015578.1|WP_015707450.1|1396873_1397287_+|hypothetical-protein
MKRALFLSTVLIFTLAGLAFGADTFTVKSFSGKVDQLEPSGQWVSVSVGGTLSASTTVKLGLNSILVVVQGDQESTIRAARQGTLESLLSAGTGGGKISVGGTVTNSTVEGNAQGVSNIPTATSRAGDTAADLDWVK
>NC_015578.1|WP_041611046.1|1397339_1399262_+|tetratricopeptide-repeat-protein
MISRQYKAIFFLLFLAFGRFARLPALDFTLRPRPFLLIPQGEVADLYAMGYGGDLLFDLDVSSILTNPWGLGYSLGLEGAFIYADLAQGAEGDIQIYSAGAGARLFGYPLSRLALSLDGAFGLSQAIQHYGHQEDGSAASWYWRAGAEAGFRFAPFFTFALNGGYRYYHNERRDGALYQGLYAGLTFQFTLSTKKAAGLRLELIQEEPVYPLFLSLYQRNGAGTLRISNYETAEIRNVRVSFRAGQYTSSEISCGNIGFIGRGRHAELPLYADFSPALLNFTEDGRILGEVVIRYTFLGSERTAVISSTVRVVNRNAYRWGDNASLAAFVSPTAPAPLEYAKYVVGLARSKRRTGLNQNMQFSLWLYEGLLTAGLRQSAGSNRVTDIDSIQFPSETLAFRSGNAVDIGLLYANTLESSGIPAAIIPLEDDFMVLYSLGISQAAADSLFTNIENLLVINDEMWMPLSMANFNNGFMNSWEGGSKRLNQAFEAGEALDFIRFADAWAAYPPVVPPVEAQSARPEEGALNRRVDTAFGIYIATELEPKIGALEAQLGANPGAASFNQLGLLLLRANRPEDAKPVFEQAASYGSAAGMVNRGNLSLLDKDFTGAEAWFTQALGLNPENAAAKNGLAQMALQRGE
>NC_015578.1|WP_148257420.1|1399362_1401744_+|tetratricopeptide-repeat-protein
MFPVLIAFLLLSAAAAYGENSIALRLSPGAAIPLGDSVFVPGFGAAGLAEWAFSLKPQSRFFSGLRLGGGFFQIAVETGSPIVFTQGKLGLFFQWRALDRLSLWVEGNGGIFTYNYSWDDTADTRLRLGGSLGADFHLTPAIALYAAADYNWHSITPDSSLTTLGINLGVRLDLLELLRKETRVAGEKKTQESVFPVSYAWYENNPLASVRVTNQEPTAINDVQLSFYLERYMGQPTLFYTIPLLKPGESVEVPVTALFNEAMMDLTENITANASLRIDYRALSQVKQAELPLQMPIYHRNAMSWDDDRRAASFVSSQDPAAKFFARHVQSITDTRLRPFKGSPERIPRNIQYALGLFEALKVYGINYVIDPSSSYIELSENASSLDTLNYPYQTLYYRGGDCDDLSILFCSMLEVLGIDTAFITIPGHIYMAFDSGLTEEEGREQFFLPDDLIYQGGKAWVPLEITQTAAPFYQAWRTGAQEWRDAGSEGSFFPMQESWARYKPVSVSDAADKMPELPDEDSLIDAIEESLNIYAGFLIRPRTRELEGQIAASSSGIAMVRRNDLGGLYGKTGMLLNAETELSRIPSNAPVALNLGNIAFVRGHYDDAESLYRESLEREPENILARLGLARTCYEQGDYAGAEREYRYLQEANPELAEQYPYLGIWRETLGQPLSYSDRLVTTLWMDAQWQLETNRIAAEAAETEWLTEAEQTAVEQEEESPALAAFYRVVYGDSLVRIAQRGYIYGDWKQWRRIYEANKAAFPRRGDPDFILPGMILRIPSINGEKRSGTW
>NC_015578.1|WP_041611490.1|1401777_1402614_-|epoxyqueuosine-reductase
MENGDFIALIRDQVKTSSGNRLKPEAALRPELAGMPFFEEPVLGFAAADDPYFGELKKPGVIGDHFLLPREWLSGARTVVSVFFPHSEAVKKANRQTMEWPADEWLQARIEGQAFIEELCRYTAAFLKDSGFSCAIPCFDPRFKTGNPAIRDNTRQDFYTSNWSERHVAHVCGLGTFGLSRGLITPKGISGRLASFISDAQFAPTVRPYSGISDYCTRCGACVRNCPAGAITLEEGKNHPLCSAFLDRTKEKHRPRYGCGKCQSAVPCESGIPAMGHS
>NC_015578.1|WP_015707453.1|1402806_1403109_+|BrnT-family-toxin
MNFEWDSEKDVKNVKIHKLSFSTAKLVFNDPERMERFDRNHSDHEARYQTLGMVDEVLFVVYTERDDITRIISARLADKDERRIYYGNSKGDFAGWTKAD
>NC_015578.1|WP_015707454.1|1403062_1403377_+|hypothetical-protein
MAIVRETLQGGQKPTKEQIDEIRNAAKYPVVYNEVSPKLTAGELAEFRRVSEINAAERERVMCSIRLQKRTLDWWKSLGEGYTAVMARLLDEARNYPDLIKKCL
>NC_015578.1|WP_041611047.1|1403450_1404536_-|DUF362-domain-containing-protein
MEKNEILVIYGKKIEEMAFSLAEAADLADLIRDRDRRIGLKPNLVVARPAADGATTHPEIARGLIRYLQKNGFQNLVILEGSWVGARTGEAFPCCGYTKLAQETGVELIDTQLDSSKPYDCKGMKIEICDSAMGVDFMINLPVMKGHCQTLMTCALKNNKGIMPDKEKRRFHTLGLDKPIAHLNTVAKNDFILVDGICGDLDFEEGGNPVYSGKLYAARDPVLCDAWTASQMGYRPEEIPYIGLAEGLGVGCGDPAKAVIRELSPPSSAIETTPSGKARQYASFIEEDQACSACYANLIFALSRMNHNELNRIKGKICIGQGFKGKPGKLGIGRCTLSCDASLKGCPPGGADIIAFLQKQV
>NC_015578.1|WP_015707456.1|1404661_1407202_+|alpha-glucan-family-phosphorylase
MNISTYTIKPKLPNSLKPLEELARNLWLSWNFDAVQLYIRLDYDVWLQSQQSPVRTLGMVSQERLAEVAKDDSYLSALNEVYGRFLKYKKGETWYRGSRKDVVAYFSMEYGMDVSLPIYSGGLGMLSGDHMKTSSDMGLPLVGIGLLYRQGYFKQYLNADGFQQETYPENDWYNMPVERKNDKNGNPLKISVDLAGRVAVAQIWEVKVGRSFLYLLDTNIEENAQDFRNITSALYGGDKETRIQQEILLGIGGIRALRALGINPAATHMNEGHAAFLGLERVREIMVEKHFNFDEAREVVWPTNIFTTHTPVPAGNERFDIGLIEKYFRPWTQTLGISWKDFLGLGRERVYDDHEPFCMTVLALKMAAYANGVSKLHGEVSRIMWKGLWPNLPLEEIPISHVTNGVHPRTWVSNNMTDLLDRYFGTHFNDEPTDLAIWDRMDRISDEELWRTHERRRERLVAFARDRIRQNLKRNGAVERRIQKAEDALSPYVLTLAFARRFATYKRGNLLLRDPDRLLRLLRDKDRPIQLIFAGKAHPMDMPGKELIKEIIHFAEHHDVESRIIFLENYDMTMGHYLTAGADVWLNTPRRPLEASGTSGMKASMNGVLNCSILDGWWDEAYNPEVGWAIGRGEEYEDTKLQDEVESKALYDLLEREIIPLFYQRGRDGLPREWIKMMKTCMKEIGHSMSSHRMLMDYSNKFYFPALKNYRRLVKDDYTEAKSLAAYMTKLHQSWDSLKINKVESNSKPVMQRGDSLTVSATIELGALKPEDVLVELYHGTVSNQGNDITNARRTEMKPLGQQGNSYQYQVRIECADTGQQGHTVRILPKHEALVHPYRTGLIKWA
>NC_015578.1|WP_041611491.1|1407719_1408364_+|NAD(P)H-dependent-oxidoreductase
MPKIIGISGSPIPDSNTDRLIKHILEESVIENEWEAEFVKLSSITVAPCRACKRCVEDNICKVADDFPALAEKLRLADAVVIGGYIPYGMLDAFTKAFLERLWSMRHVHNLNKDKVFITVISGLSKQGRETALRLMAVELKMERVRHIAELQIEGNVPCLTCGHGDNCWGSGVPRHYPGAKASADLCVAVENQAVWGEASKIAEMVRGLGNRSS
>NC_015578.1|WP_041611049.1|1408430_1408838_-|PIN-domain-containing-protein
MSDDVAFLDTNVLIYAYSEDDLRKQNIAVNAIDTHKCIVSTHILNEFCNVCIKKLHYPIDQILESINEILHACALFMVNENTIKEALVIQDRYKYSYYDSLVIASALKCECTLLLSEDLQDSQKINNTTIKNIFI

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Crispr_ID: NC_015578_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015578_8

1526418-1526560

Orphan

Consensus_repeat	Method
TTGCGCGGGGAACTGCGTTGCAAGTTGCGCAGCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015578_8

>merge|NC_015578|8|1526418-1526560|CRISPRCasFinder
CTGCGCGGGGAACTGCGTTGCAAGTTGCGCGGGGAACTGCGTTGCAAGTTGCGCAGCTTATGTTGCGTGAAACAGGAGTTATGCCAGGCCGAGCTTGGCTTCCATAGAATTGCGCGGGAAACTGCGTTGCAAGTTGCGCAGCT

>NC_015578|8|6|1526418-1526560|CRISPRCasFinder
CTGCGCGGGGAACTGCGTTGCAAGTTGCGCGGGG	AACTGCGTTGCAAGTTGCGCAGCTTATGTTGCGTGAAACAGGAGTTATGCCAGGCCGAGCTTGGCTTCCATAGAA
TTGCGCGGGAAACTGCGTTGCAAGTTGCGCAGCT

Protein	Signature genes	Signature genes Name	Protein_function
NC_015578.1\|WP_015707577.1\|1531120_1532191_+\|uracil-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|223113
NC_015578.1\|WP_041611059.1\|1527107_1528247_+\|(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate-synthase	unknown	unknown	gnl\|CDD\|377382
NC_015578.1\|WP_148257250.1\|1534208_1536278_-\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015707569.1\|1522488_1523787_+\|V-type-ATP-synthase-subunit-B	unknown	unknown	gnl\|CDD\|179373
NC_015578.1\|WP_015707570.1\|1523798_1524401_+\|V-type-ATP-synthase-subunit-D	unknown	unknown	gnl\|CDD\|179382
NC_015578.1\|WP_015707568.1\|1520658_1522419_+\|V-type-ATP-synthase-subunit-A	unknown	unknown	gnl\|CDD\|235248
NC_015578.1\|WP_052299795.1\|1529341_1530457_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015707566.1\|1519441_1520056_+\|ATP-synthase-subunit-E	unknown	unknown	gnl\|CDD\|179302
NC_015578.1\|WP_148257429.1\|1520122_1520662_+\|DUF2764-family-protein	unknown	unknown	gnl\|CDD\|314007
NC_015578.1\|WP_015707578.1\|1532187_1533213_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NC_015578.1\|WP_015707574.1\|1528563_1529124_+\|DUF3996-domain-containing-protein	unknown	unknown	unknown
NC_015578.1\|WP_041611058.1\|1514910_1516935_+\|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme	unknown	unknown	gnl\|CDD\|335469
NC_015578.1\|WP_015707572.1\|1526648_1527089_+\|ATP-synthase-subunit-K	unknown	unknown	gnl\|CDD\|180645
NC_015578.1\|WP_015707562.1\|1513302_1514667_+\|bacterial-Ig-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|369401
NC_015578.1\|WP_015707565.1\|1518267_1519320_+\|galactose-mutarotase	unknown	unknown	gnl\|CDD\|185696
NC_015578.1\|WP_015707576.1\|1530517_1531096_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015707564.1\|1516944_1518144_-\|NADP-dependent-isocitrate-dehydrogenase	unknown	unknown	gnl\|CDD\|236226
NC_015578.1\|WP_015707579.1\|1533227_1533515_+\|DUF503-domain-containing-protein	unknown	unknown	gnl\|CDD\|377364
NC_015578.1\|WP_148257430.1\|1533593_1534217_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015707571.1\|1524426_1526364_+\|ATP-synthase-subunit-I	unknown	unknown	gnl\|CDD\|235600

Protein	Function_ID	Function_description	E-value
NC_015578.1\|WP_015707577.1\|1531120_1532191_+\|uracil-phosphoribosyltransferase	gnl\|CDD\|223113	COG0035, Upp, Uracil phosphoribosyltransferase [Nucleotide transport and metabolism].	8.16932e-48
NC_015578.1\|WP_041611059.1\|1527107_1528247_+\|(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate-synthase	gnl\|CDD\|377382	pfam04551, GcpE, GcpE protein. In a variety of organisms, including plants and several eubacteria, isoprenoids are synthesized by the mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway. Although different enzymes of this pathway have been described, the terminal biosynthetic steps of the MEP pathway have not been fully elucidated. GcpE gene of Escherichia coli is involved in this pathway.	6.7383e-163
NC_015578.1\|WP_015707569.1\|1522488_1523787_+\|V-type-ATP-synthase-subunit-B	gnl\|CDD\|179373	PRK02118, PRK02118, V-type ATP synthase subunit B; Provisional.	0
NC_015578.1\|WP_015707570.1\|1523798_1524401_+\|V-type-ATP-synthase-subunit-D	gnl\|CDD\|179382	PRK02195, PRK02195, V-type ATP synthase subunit D; Provisional.	3.14737e-78
NC_015578.1\|WP_015707568.1\|1520658_1522419_+\|V-type-ATP-synthase-subunit-A	gnl\|CDD\|235248	PRK04192, PRK04192, V-type ATP synthase subunit A; Provisional.	0
NC_015578.1\|WP_015707566.1\|1519441_1520056_+\|ATP-synthase-subunit-E	gnl\|CDD\|179302	PRK01558, PRK01558, V-type ATP synthase subunit E; Provisional.	2.64192e-49
NC_015578.1\|WP_148257429.1\|1520122_1520662_+\|DUF2764-family-protein	gnl\|CDD\|314007	pfam10962, DUF2764, Protein of unknown function (DUF2764). This bacterial family of proteins has no known function.	1.16038e-05
NC_015578.1\|WP_015707578.1\|1532187_1533213_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	1.04988e-13
NC_015578.1\|WP_041611058.1\|1514910_1516935_+\|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme	gnl\|CDD\|335469	pfam03781, FGE-sulfatase, Sulfatase-modifying factor enzyme 1. This domain is found in eukaryotic proteins required for post-translational sulfatase modification (SUMF1). These proteins are associated with the rare disorder multiple sulfatase deficiency (MSD). The protein product of the SUMF1 gene is FGE, formylglycine (FGly),-generating enzyme, which is a sulfatase. Sulfatases are enzymes essential for degradation and remodelling of sulfate esters, and formylglycine (FGly), the key catalytic in the active site, is unique to sulfatases. FGE is localized to the endoplasmic reticulum (ER) and interacts with and modifies the unfolded form of newly synthesized sulfatases. FGE is a single-domain monomer with a surprising paucity of secondary structure that adopts a unique fold which is stabilized by two Ca2+ ions. The effect of all mutations found in MSD patients is explained by the FGE structure, providing a molecular basis for MSD. A redox-active disulfide bond is present in the active site of FGE. An oxidized cysteine residue, possibly cysteine sulfenic acid, has been detected that may allow formulation of a structure-based mechanism for FGly formation from cysteine residues in all sulfatases. In Mycobacteria and Treponema denticola this enzyme functions as an iron(II)-dependent oxidoreductase.	2.46037e-14
NC_015578.1\|WP_015707572.1\|1526648_1527089_+\|ATP-synthase-subunit-K	gnl\|CDD\|180645	PRK06649, PRK06649, V-type ATP synthase subunit K; Validated.	1.27038e-42
NC_015578.1\|WP_015707562.1\|1513302_1514667_+\|bacterial-Ig-like-domain-containing-protein	gnl\|CDD\|369401	pfam07523, Big_3, Bacterial Ig-like domain (group 3). This family consists of bacterial domains with an Ig-like fold. Members of this family are found in a variety of bacterial surface proteins.	4.00956e-06
NC_015578.1\|WP_015707565.1\|1518267_1519320_+\|galactose-mutarotase	gnl\|CDD\|185696	cd09019, galactose_mutarotase_like, galactose mutarotase_like. Galactose mutarotase catalyzes the conversion of beta-D-galactose to alpha-D-galactose. Beta-D-galactose is produced by the degradation of lactose, a disaccharide composed of beta-D-glucose and beta-D-galactose. This epimerization reaction is the first step in the four-step Leloir pathway, which converts galactose into metabolically important glucose. This epimerization step is followed by the phosophorylation of alpha-D-galactose by galactokinase, an enzyme which can only act on the alpha anomer. A glutamate and a histidine residue of the galactose mutarotase have been shown to be critical for catalysis, the glutamate serves as the active site base to initiate the reaction by removing the proton from the C-1 hydroxyl group of the sugar substrate, and the histidine as the active site acid to protonate the C-5 ring oxygen. Galactose mutarotase is a member of the aldose-1-epimerase superfamily.	1.59406e-161
NC_015578.1\|WP_015707564.1\|1516944_1518144_-\|NADP-dependent-isocitrate-dehydrogenase	gnl\|CDD\|236226	PRK08299, PRK08299, NADP-dependent isocitrate dehydrogenase.	0
NC_015578.1\|WP_015707579.1\|1533227_1533515_+\|DUF503-domain-containing-protein	gnl\|CDD\|377364	pfam04456, DUF503, Protein of unknown function (DUF503). Family of hypothetical bacterial proteins.	2.43792e-27
NC_015578.1\|WP_015707571.1\|1524426_1526364_+\|ATP-synthase-subunit-I	gnl\|CDD\|235600	PRK05771, PRK05771, V-type ATP synthase subunit I; Validated.	3.97075e-96

>NC_015578.1|WP_015707571.1|1524426_1526364_+|ATP-synthase-subunit-I
MIVPMKKVSLVVRDRTQVEALTTLRGLGVLHLEKRDASSDALSKALEQKASAENALGILQLLEQPKKGAAKNRNQADQTRRSSDAGNEETEPYSADAVNAPARPDLVDLILNLGKDQKACEDQKIVLDREQQRLEKWGDFKPGLIQELAEQGIKLHLYELSPNALANIPEEIRYIISGQDKATVRLVVLDQEIPGLQSFRLPEKSLSELGQEQAELSAKLQGIKERLNKLADRKSSLIHEIAQLQEQVDLEFARASLEQIDEVPPEYAVSWISGYAPQEDVGAIKRAAAEHGWAMIADDPGPDDDVPTKLKNNKLVSLIYPLTDFLEVVPGYQETDISGWFLFFFTIFFGMIFGDAVYGLLFIIIALIGIAKTAKKGVPAIFKLVLLLGFSNFVWGILTCTWGGMDADKLPLFLQNISLPLISNVTAGKSEYYSGIVQQNLMIFCFSLAVLQLSIGHIIKIFKSRTLKLLGDLGSAAMLGGMYFIVLSLIASNASRQIPFYMSAVYAFAAGFVLNFLFANYDGSIGRSIMESLKNMVSVILNIANVFSDIMSYIRLWAVGLAGGAIALTVNSMAGPMLGHMVFFIFGIALLIFGHGLNMVLNVLSVLVHGVRLNTLEFSGHVGLTWSGHAYRPFAKRVKDEAQSA
>NC_015578.1|WP_015707570.1|1523798_1524401_+|V-type-ATP-synthase-subunit-D
MAKIKLTKNELKKQRDSLKMYQRYLPTLMLKKQQLQGEIRTTEMRIKELREERDLLDETFKDWVGVFGEKGIFTTAILSIVRIKTSEGNIAGVAIPIFQGAEFETANYDLARTPLWLDLAVEKMKQVILLDLEAQVLEEQRKRLDHELRITTQRVNLFEKIKIPETKGSIKKIGVYLGDQQTSAVVRGKIAKSGLEKAAK
>NC_015578.1|WP_015707569.1|1522488_1523787_+|V-type-ATP-synthase-subunit-B
MNKVYSKIESITGSVITVKAEGIRYGDLAEVDTVFGTSLAEVNRLAGDLVSLQVFAGGRGISTGDTVRFLGRPMQVAFSENLMGRVFSGSGTPRDNGPALTDNPIPIGGPSVNPANRIIPRNMIRTGIPMIDLFNTLVVSQKLPIFSVSGEPYNDLLARIAMQAEVDVIILGGMGLKYDDYLFFKDTLEEGGALSRTVMFVHTASDPTVECLMIPDMSLAVAEQFALQGKDVLVLLTDMTNFADAMKEISIIQEQVPSNRGYPGDLYSQLASRYEKAVDFESAGSITILGVTTMPGDDVTHPVPDNTGYITEGQYYLKNGRIEPFGSLSRLKQQVNGKTRADHRALMDGMIKLYSAFRDTLEKKAMGFIMTAWDDKLLKYGDLFEKKMMDLTVNIPLEKALDLGWEILSDCFSPEETGLRTELINQFWPKKD
>NC_015578.1|WP_015707568.1|1520658_1522419_+|V-type-ATP-synthase-subunit-A
MIGTKGTVVAVNGNMVSVRFDGAVSMNEVGFVKLGDKKLKSEVIRIRGDISQLQVFEVTKGISVGDSVEYSGDMLAVEVGPGLLGQVYDGLQNPLPKLAAVAGNFLERGVYLDPLSVDISWAFTPVAKVGDTVERADTLGTVPEGAFTHRIMVPFNLYGTYTIASIKGAGSYTIRDTIAELKDEKGNTIPVTMSFRWPVKRPIDCFVERYKPTEPMVTRVRLIDTFFPVARGGTYCIPGPFGAGKTVLQQITSRYADIDIVILAACGERAGEVVETLKEFPELTDPKTGKSLMERTIIICNTSSMPVASREASVYTAVTLAEYYRQMGLNVLLLADSTSRWAQAMREMSGRLEEIPGEEAFPAYLESTIASFYERAGTVRLRDGSIGSVTIGGTVSPAGGNFEEPVTQATLKVVGAFHGLSRERSDARKFPAIHPLDSWSKYKGIIAAEKVGYAHGFMRRGSEVEQMMKVVGEEGTSIEDYVIYLKGDLIDSVYFQQNSFDAVDAAVSPDRQKHIFAILLHILASQFTFPDKNEARSWFNRLRQKFLDFNGSEWQSERFVSLQKEIESTVSAQSTGLDKAAEKVLA
>NC_015578.1|WP_148257429.1|1520122_1520662_+|DUF2764-family-protein
MNFGYFEELAEKFLDATDKAFFDMISLAPDSLGPEGDGTPSYAELPRSTGCEFIDKWREWERALRLNLARYRSQRLKRDNVVSVEPPLLPVEASAAAARAVAVSDSPLEAEEILDKARWDLIGSIQGLDSFSQDIIFAYKLKLLILERRLSFKTEEGFKEYKSLYAAILDSAQSVGEAK
>NC_015578.1|WP_015707566.1|1519441_1520056_+|ATP-synthase-subunit-E
MEIQLQELIDKIKKDGITSASEEASKLKSQAEADAGRITESARKEAAEIVSKAKADAERLEKAGTAALEQASRNLVLAFKGEIDALLSKIVAAKTGSSYGDDTLKAILPELVKSWASKGSDSLDLILSEDNLTKLRGYFNEQLASEISKGVELKSDRNLGAGFRIASKDGAAYYDFSAESVAELLSAYLNPRLSEILKSSAKGN
>NC_015578.1|WP_015707565.1|1518267_1519320_+|galactose-mutarotase
MKITEKTFGILSTGKKATLFTLKAGELTLSLSSFGAIWTSLLVPSGKEGTADILLGYSTLDGYTHNKPHIGATIGRFGNRIRDGRFALNGKTYTLPKNDGEHCLHGGLRGFDKLLWKGEAYKERDGVFVRFELRSPDGDQGFPGNLKAVVSYGITKSHEIIADYRAKVDTPCPINLTNHAYFNLAGEGSGDILDHELELYASSYLAVDSSLIPTGELTPTAGSPFDFSSRKPIGRDFQGTLGKNGSSGPGYDHCFVVDGENGKLRPCADVLEPRSGRSMRVFTTQPGVQFYTGNFLDDLPGKAGSVYTRHSGFCLETQYLPDSPNRGEFPSCIFGPQREYHEKAIFSLNW
>NC_015578.1|WP_015707564.1|1516944_1518144_-|NADP-dependent-isocitrate-dehydrogenase
MARRISMKNPIVEIDGDEMTRVLWALVKEKLILPRVDLKTEYYDLGLANRDATADSVSAESARAIQRLGVGVKCATITANAARQTEYKLQALYPSPNATIRAILDGTVFRKPISVSCIKPSIASWTKPIVIGRHAYGDIYKAAEMRIPGPGKVELVYTGANGAEQRVLVADMKSSGIAQGMHNLDDSIRSFARSCFLYAIGEKLPVWFATKDTISKTYDGRFKELFAEIYETEFKEKCAAAGVQYFYTLIDDAVARTVKGDGGFLWACKNYDGDVMSDMVASAAGSLAMMTSVLVSPSGAVEYEAAHGTVQQHYYRWQKGEKTSTNPVALIFAWTGALAKRAELDSLPDLAAFARNLEKAALAAIEAGEMTADLARLAVPAPPRPLDSWEFIDAVAARL
>NC_015578.1|WP_041611058.1|1514910_1516935_+|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme
MIPALAIAWGLIAACTPALSAPSLTGEEESAWVRVILGDREESPGARTVVPADPLFSYTLTFTSDDYTEVKKECTDTDILVKLGKGDWELKVEGKKAGITVAESDTMHLSMLTKEAAPKTLRVVLHPLTTFTLADGSFRYDIQFDSGLTITEAGLTLSPIDSGTATAPIDLLLQGSGDISLAPGYYRLRVTARQNQQVAARGDIVHIYSDTQTAKEYTFTENDFAESVFLAGTANSAGYTPRWVYVYQGEDCTNQLADAEASGGKWELFVPSSYGKVYIKTELEKEGAIFFSKPELYPADGSSIPAGGDAHVSLAVNRYDITKNAMPYGNISMLSAAFENEQVSITVNPNNVYHLRPDSLRYTPEGAAAVVIPWTANPASFAMPARTVAMDAVFDSDIALLHVPSQGITFPTGDSDTGRNTLGYNFSLGETEVTYELWYRVRMWAKDHGYIFDNPGTVQGTDYAPGITPASLGNRRLQPITKVNWYDALVWCNAMTEWYNAETGSSFEPVYVRGNNVVRNSTVNTTTLGIKPGAKGFRLPSIVEWEFAARWQGEERDFTAAIGISSNGTQYYFTPGNYASGAMNPVTNNNETSRVAVFSGTAALTIKQRAPNQLGFYDMSGNVQEWCIETAISHWEIRGGSFEDDLSAMALGRSISYGPLRADRDTGFRVAQTE
>NC_015578.1|WP_015707562.1|1513302_1514667_+|bacterial-Ig-like-domain-containing-protein
MKQFYWLLISFAAVIVSGCSNPFFPKKPEIPPEPKAVLESLRISQEPNKSFYIIGEDFDHQGLEVIGLYSDNTEKIEPIDRENLSGYDEETPGPQDITVSVEEETATFTVIVCDLDHIAVSATPQKLNYAKGEALDITGLEIIGYYAYEDSPFLSQNEPVFPENLSGYNMEIPSPQSVTVTIKEKTAGFAIKVFPLEWLEITGKGKEYYVLGEELDLDSMEVTGHYVDPNDPYTEVTRIETLEPGMISGYDPDAMGSQTVTITIDGKTEVFTIKVWEFIDLVISSLPLKKIYTKGDELDLKGLVVIGTYTDDGSNTVEREETITLDNIIGYDKDLQDVQIITVKVRHLEVSFTITVEGQVQVLIYLDAPPGGVPEHITLSKTGVNFPSEVELTLSLEYEEYGWFINNSDSAASLSETFVLNAHGLPLSDNLLRIEVKTFEGIYYGKELVFTIVK
>NC_015578.1|WP_015707572.1|1526648_1527089_+|ATP-synthase-subunit-K
MNLGLLSAGLVLGISAVGSGLGISIAGRAVIGAWKKCYLNNKPAPMTLIAFGGAPLTQTFYGFILGLLFMKPAALAHPENGALYLGIGIASAFAIAGSAIAQGQAGAAGADATGETGKGFVNYMMIVGICETVAIFAMVLSMISLN
>NC_015578.1|WP_041611059.1|1527107_1528247_+|(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate-synthase
MSERVSRTVTVGGLKSPGGSMQTVSIGGGLPVVIQTMWKDRLSFSDLEGPSGEKTVERIRRLQAMGCALLRFAVPDLEAAEVLGNLAAMVSMPLVADIHFDYKIALRCLDFPIAKIRINPGNIGGRDRVEKVLSKAAAQGVPIRIGVNAGSLPRDLGLRVDAGELSRAEALVGAAERELGIFDEFGFSNTLVSMKASSVAETIRANRLLAERTDAPLHIGVTEAGPLIAGVTRNAIALHALLSEGLGDTIRVSLSDTMENEVIAGREILNTAVEGSEAARERQGKRGGVTIISCPRCGRNSFDTHGFTQRWLDTFYAMDKTITVAVMGCAVNGPGEGRHADLGITGAGNKALIFRHGEVIRTIDAADADTAFREELDRV
>NC_015578.1|WP_015707574.1|1528563_1529124_+|DUF3996-domain-containing-protein
MKKVLAIFIVGLCLSTAAVFAQHPEGTGIGIVGQYGLVGGGIGPALSLKLAPVPVYWSVNLKIDDDIFGIGLAGDYYFFDESLTGSSDFNLGWYLGAGIGAGISFGSWDGYMGDYNHFGFNAAARLPIGLSAVFVKKVEVFLGFVPALGFDYASVTYKPKVGSNSTDSDFDIDFDIGGEIGIRIWL
>NC_015578.1|WP_052299795.1|1529341_1530457_+|hypothetical-protein
MRKKSVLSFLILVLGCTAVFAQTRVQRPYWYTLERGKLHFRNGEYGDALVAFEDARNQRRVMYTRMEEDLIALLSLPEVRRMNNSLELIEPYIVERGYIDAAAALTECYYRFPKESLADNALNALAAIGRYKDFPDAEYWIGETYRVEGELGIALKQYEKAYEQRLLLETPGFDLEILYKIVDVHRLRQEYVAMEERLLEILKRDTLWSEDASSFVRTAMMRTLENDGVNRFLTLYRYSNQDVEPAHRLLGLYYHASGRHNRAVEHLLFAFLIQNTAMVDEIQRNQFDFVFTTLDAFSALITRRPALQAYIEDVEYYKTIYYLGTALNGSGRLPPARELWAFLSRRQAGEWTTRSVAQLRSPFLERAIEMP
>NC_015578.1|WP_015707576.1|1530517_1531096_+|hypothetical-protein
MKKFLSAIFLCSVISGVSIFAFEAEDLKTYPDVTPAGSFAINGGIGINALGSKYGELTVPPLSVSADYALPLGGLPFFVGGIFGFYASRDSWKEWTTSYEYTGLFFDIGARFGYHFNWTVPNLDTYAVATLGVGIESSNLKIAGKNHPDTDPAVLFGVAIGGRYFFTPNLGAFLELGYSSLSIVTLGVSFKF
>NC_015578.1|WP_015707577.1|1531120_1532191_+|uracil-phosphoribosyltransferase
MSKIVLKAEDLDGYLTEADKAYLVQMDEIYKEVLNCFNILTLTRSVSERKQAEDKLIAFYNRMGTLMQDICRNSPGIQVYSFLTPNESHAEASRLIAKLRDVRTENQEFVYYIQRAYEMLFKLAYGGQSGENKNYLIVKTPVTVPVQNYAVHKITNIDSRIENTVMCVMLRGALLPSMIMSKEIQEYSSHGYVSPFALFRIRRDDSKHENDMEYILDLDKSYFSLESLDGKDLVFADPMNATGGSLVTVVKYLLDQGIKPRSVQFFNVIAALKGALRVVRALDNCQVYTLWMDPVLNDAAYIMPGLGDAGDRINGRDMEEYPRNIIQLIADYGSNIAKLYRAQLREIEHTVLGFQK
>NC_015578.1|WP_015707578.1|1532187_1533213_+|tetratricopeptide-repeat-protein
MKRPALLLFFSIFCFFSCASGGVTTAEEYYSLGMAYFDMGKYAEAEKWLNRARMMDKTKVASEYNLGRIAFETGRYQDAVRHFDRILAKDKDNVMALKAAAYTRIKTSEFVLAEGLYSRVLTLEPESVDQGYNYALVLMALEKPEQAEDVLLKYQVAMADNKDTLLLLARARKALNKVEAVDDYNEWLQTNSDNTVRYEYAQVLESAQFYARALEEYRTVVNALPQGQSASPPVPGTLDRASVRFTIARLLLIADPEKTDGITELETAITDGFSDTEKLEILLTEPGISAASKDEIHRVIENLEKAKLDAEKAEAEKAEAEAKEPPEDDGQDSIDDAAMEG
>NC_015578.1|WP_015707579.1|1533227_1533515_+|DUF503-domain-containing-protein
MIVSMIQMIFQIPDVDSIKAKRQIVRSVKDKLQHRFHMSAAEVDLQDSLSFAQIGGALVSNSKVFGESVLHKAFEMIENEVPVRIQDVSIHSEEF
>NC_015578.1|WP_148257430.1|1533593_1534217_+|hypothetical-protein
MLFFTLFFASCVGVHSDITIRKDGSGTIALEYRLSRELESLGKLDGNQGWLPLPVGKADFERTVARVQGLSLGSFNTKITGQDSITQVKLNFTNLDALARFLDSTGQGVSLVREGEKTRMTLGFSGAAGAQNRELMTLVSEAMESYTLDFGLTLPNEAELRILGENGQVLSAPPAGTLMVQGSRIVYSSPMAELLSSPGRVVLDILW
>NC_015578.1|WP_148257250.1|1534208_1536278_-|hypothetical-protein
MSSIRRGMLILLFFVPGMILPAEERVQNIPALETSRRVMLAGILRERKIPFEERSLFAGYGGFGFSIHVSLPASTNEGGEKKPGTFILAVPLSGAENTGDTKNPEDFPFGFDLALGFIEKVLAEGTETDILVAFLGDEWTALPHPAEDPHRGLEDLYSRIAVPESTGLVYLDMNLPSGEIVIHHGAQKALAPLHILKPLGSLCESRGIPYTLAIRFNELYKLGLAEGPSPLEFAYARSIPAIYISGNNAVPANPAGSTLDAPALGELILDYVRALDLGAENHDYHYLVFQYFGKTLFVPEYATVLFFLAIAALFVFAVLIYSVVFRFRLAVQWKIFLKQSWILLLFYLLLVLSLSGASLLFRLLIQDTGTLTGLRGNAPALFYAAAGIQLLGIALFTLISPALNLIYVPRRANFYGSSAVILSALEILLAAFLDITFIPIFIWVFFFTFLASCFTQPLLIWLCAIFSFLRGAEALRALYLTGNTQFETLILSGNIPVILYVALISLPFFIILKRGRVIQGREKNQPWLFKGVPGFTVLVCAAASLGTGIFFLNRIPASLPIPPREAPGSLDMKVTSRVWLERRTLGITLEAPGHPLKFELYLDGSAETPGQEIPIIYSAPMPFRYIEDENLNSMEFVLGEGPPNPFTTEIVLPVNFNGYLRAEAVYLEGKDGDYQPRLSRRLPVGGISP

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Crispr_ID: NC_015578_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015578_9

1777064-1777170

Orphan

Consensus_repeat	Method
ATGGGAGGCAACAGTGCCATCACCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015578_9

>merge|NC_015578|9|1777064-1777170|CRISPRCasFinder
ATGGGAGGCAACAGTGCCATCACCGGGAATACTGCCTCCACCAATGGCGGCGGGGTGTATGTGGATGCGGGGTCGTTTACCATGGAAGGCAACAGTGCCATCACCGG

>NC_015578|9|7|1777064-1777170|CRISPRCasFinder
ATGGGAGGCAACAGTGCCATCACCGG	GAATACTGCCTCCACCAATGGCGGCGGGGTGTATGTGGATGCGGGGTCGTTTACC
ATGGAAGGCAACAGTGCCATCACCGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_015578.1\|WP_015707778.1\|1787213_1788230_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223521
NC_015578.1\|WP_148257437.1\|1761839_1763690_+\|type-IIA-DNA-topoisomerase-subunit-B	unknown	unknown	gnl\|CDD\|235501
NC_015578.1\|WP_015707774.1\|1782154_1783702_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173853
NC_015578.1\|WP_148257261.1\|1770279_1770753_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_148257262.1\|1770758_1771997_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372583
NC_015578.1\|WP_015707775.1\|1783745_1785296_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173853
NC_015578.1\|WP_015707766.1\|1769419_1770199_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|379312
NC_015578.1\|WP_015707763.1\|1763764_1765882_+\|sodium-translocating-pyrophosphatase	unknown	unknown	gnl\|CDD\|376979
NC_015578.1\|WP_015707781.1\|1790292_1791318_+\|M42-family-peptidase	unknown	unknown	gnl\|CDD\|349906
NC_015578.1\|WP_148257260.1\|1760425_1761556_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224117
NC_015578.1\|WP_015707773.1\|1780315_1781971_+\|2,3-bisphosphoglycerate-independent-phosphoglycerate-mutase	unknown	unknown	gnl\|CDD\|293734
NC_015578.1\|WP_015707770.1\|1772724_1773690_+\|putative-lipoprotein	unknown	unknown	gnl\|CDD\|293019
NC_015578.1\|WP_015707765.1\|1767502_1769419_+\|DNA-topoisomerase-IV-subunit-A	unknown	unknown	gnl\|CDD\|236598
NC_015578.1\|WP_015707764.1\|1765961_1767353_-\|GntP-family-permease	unknown	unknown	gnl\|CDD\|225330
NC_015578.1\|WP_015707769.1\|1772024_1772750_+\|FecR-domain-containing-protein	unknown	unknown	gnl\|CDD\|377406
NC_015578.1\|WP_041611545.1\|1789259_1790291_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|349906
NC_015578.1\|WP_015707776.1\|1785387_1786329_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NC_015578.1\|WP_015707777.1\|1786339_1787212_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NC_015578.1\|WP_041611081.1\|1777523_1780277_+\|CHASE2-domain-containing-protein	unknown	unknown	gnl\|CDD\|143636
NC_015578.1\|WP_015707779.1\|1788226_1789246_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|236898

Protein	Function_ID	Function_description	E-value
NC_015578.1\|WP_015707778.1\|1787213_1788230_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	3.68206e-164
NC_015578.1\|WP_148257437.1\|1761839_1763690_+\|type-IIA-DNA-topoisomerase-subunit-B	gnl\|CDD\|235501	PRK05559, PRK05559, DNA topoisomerase IV subunit B; Reviewed.	0
NC_015578.1\|WP_015707774.1\|1782154_1783702_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|173853	cd00995, PBP2_NikA_DppA_OppA_like, The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold. This family represents the periplasmic substrate-binding domain of nickel/dipeptide/oligopeptide transport systems, which function in the import of nickel and peptides, and other closely related proteins. The oligopeptide-binding protein OppA is a periplasmic component of an ATP-binding cassette (ABC) transport system OppABCDEF consisting of five subunits: two homologous integral membrane proteins OppB and OppF that form the translocation pore; two homologous nucleotide-binding domains OppD and OppF that drive the transport process through binding and hydrolysis of ATP; and the substrate-binding protein or receptor OppA that determines the substrate specificity of the transport system. The dipeptide (DppA) and oligopeptide (OppA) binding proteins differ in several ways. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Similar to the ABC-type dipeptide and oligopeptide import systems, nickel transporter is comprised of five subunits NikABCDE: the two pore-forming integral inner membrane proteins NikB and NikC; the two inner membrane-associated proteins with ATPase activity NikD and NikE; and the periplasmic nickel binding NikA, which is the initial nickel receptor that controls the chemotactic response away from nickel. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand binding domains of ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	8.32455e-124
NC_015578.1\|WP_148257262.1\|1770758_1771997_+\|hypothetical-protein	gnl\|CDD\|372583	pfam13372, Alginate_exp, Alginate export. This domain forms an 18-stranded beta-barrel pore which is likely to act as an alginate export channel.	0.00355166
NC_015578.1\|WP_015707775.1\|1783745_1785296_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|173853	cd00995, PBP2_NikA_DppA_OppA_like, The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold. This family represents the periplasmic substrate-binding domain of nickel/dipeptide/oligopeptide transport systems, which function in the import of nickel and peptides, and other closely related proteins. The oligopeptide-binding protein OppA is a periplasmic component of an ATP-binding cassette (ABC) transport system OppABCDEF consisting of five subunits: two homologous integral membrane proteins OppB and OppF that form the translocation pore; two homologous nucleotide-binding domains OppD and OppF that drive the transport process through binding and hydrolysis of ATP; and the substrate-binding protein or receptor OppA that determines the substrate specificity of the transport system. The dipeptide (DppA) and oligopeptide (OppA) binding proteins differ in several ways. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Similar to the ABC-type dipeptide and oligopeptide import systems, nickel transporter is comprised of five subunits NikABCDE: the two pore-forming integral inner membrane proteins NikB and NikC; the two inner membrane-associated proteins with ATPase activity NikD and NikE; and the periplasmic nickel binding NikA, which is the initial nickel receptor that controls the chemotactic response away from nickel. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand binding domains of ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	2.50362e-130
NC_015578.1\|WP_015707766.1\|1769419_1770199_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	4.29605e-20
NC_015578.1\|WP_015707763.1\|1763764_1765882_+\|sodium-translocating-pyrophosphatase	gnl\|CDD\|376979	pfam03030, H_PPase, Inorganic H+ pyrophosphatase. The H+ pyrophosphatase is an transmembrane proton pump involved in establishing the H+ electrochemical potential difference between the vacuole lumen and the cell cytosol. Vacuolar-type H(+)-translocating inorganic pyrophosphatases have long been considered to be restricted to plants and to a few species of photo-trophic bacteria. However, in recent investigations, these pyrophosphatases have been found in organisms as disparate as thermophilic Archaea and parasitic protists.	0
NC_015578.1\|WP_015707781.1\|1790292_1791318_+\|M42-family-peptidase	gnl\|CDD\|349906	cd05656, M42_Frv, M42 Peptidase, endoglucanases. Peptidase M42 family, Frv (Frv Operon Protein; Endo-1 4-Beta-Glucanase; Cellulase Protein; Endoglucanase; Endo-1 4-Beta-Glucanase Homolog; Glucanase; EC. 3.2.1.4) subfamily. Frv is a co-catalytic metallopeptidase, found in archaea and bacteria, including Pyrococcus horikoshii tetrahedral shaped phTET1 (DAPPh1; FrvX; PhDAP aminopeptidase; PhTET aminopeptidase; deblocking aminopeptidase), phTET2 (DAPPh2) and phTET3 (DAPPh3), Haloarcula marismortui TET (HmTET) as well as Bacillus subtilis YsdC. All of these exhibit aminopeptidase and deblocking activities. The HmTET is a broad substrate aminopeptidase capable of degrading large peptides. PhTET2, which shares 24% identity with HmTET, is a cobalt-activated peptidase and possibly a deblocking aminopeptidase, assembled as a 12-subunit tetrahedral dodecamer, while PhTET1 can be alternatively assembled as a tetrahedral dodecamer or as an octahedral tetracosameric structure. The active site in such a self-compartmentalized complex is located on the inside such that substrate sizes are limited, indicating function as possible peptide scavengers. PhTET2 cleaves polypeptides by a nonprocessive mechanism, preferring N-terminal hydrophobic or uncharged polar amino acids. Streptococcus pneumoniae PepA (SpPepA) also forms dodecamer with tetrahedral architecture, and exhibits selective substrate specificity to acidic amino acids with the preference to glutamic acid, with the substrate binding S1 pocket containing an Arg allows electrostatic interactions with the N-terminal acidic residue in the substrate. The YsdC gene is conserved in a number of thermophiles, archaea and pathogenic bacterial species; the closest structural homolog is Thermotoga maritima FrwX (34% identity), which is annotated as either a cellulase or an endoglucanase, and is possibly involved in polysaccharide biosynthesis or degradation.	5.87356e-117
NC_015578.1\|WP_041611081.1\|1777523_1780277_+\|CHASE2-domain-containing-protein	gnl\|CDD\|143636	cd07302, CHD, cyclase homology domain. Catalytic domains of the mononucleotidyl cyclases (MNC's), also called cyclase homology domains (CHDs), are part of the class III nucleotidyl cyclases. This class includes eukaryotic and prokaryotic adenylate cyclases (AC's) and guanylate cyclases (GC's). They seem to share a common catalytic mechanism in their requirement for two magnesium ions to bind the polyphosphate moiety of the nucleotide.	1.19174e-52
NC_015578.1\|WP_015707773.1\|1780315_1781971_+\|2,3-bisphosphoglycerate-independent-phosphoglycerate-mutase	gnl\|CDD\|293734	cd16010, iPGM, 2 3 bisphosphoglycerate independent phosphoglycerate mutase iPGM. The 2,3-diphosphoglycerate- independent phosphoglycerate mutase (iPGM) catalyzes the interconversion of 3-phosphoglycerate (3PGA) and 2-phosphoglycerate (2PGA). They are the predominant PGM in plants and some other bacteria, including endospore forming Gram-positive bacteria and their close relatives. The two steps catalysis is a phosphatase reaction removing the phosphate from 2- or 3-phosphoglycerate, generating an enzyme-bound phosphoserine intermediate, followed by a phosphotransferase reaction as the phosphate is transferred from the enzyme back to the glycerate moiety. The iPGM exists as a dimer, each monomer binding 2 magnesium atoms, which are essential for enzymatic activity.	0
NC_015578.1\|WP_015707770.1\|1772724_1773690_+\|putative-lipoprotein	gnl\|CDD\|293019	pfam16410, DUF5018, Domain of unknown function (DUF5018). This family of proteins is functionally uncharacterized. This family is found in various Bacteroides and Alistipes species. Proteins in this family are around 600 amino acids in length.	0.000946375
NC_015578.1\|WP_015707765.1\|1767502_1769419_+\|DNA-topoisomerase-IV-subunit-A	gnl\|CDD\|236598	PRK09631, PRK09631, DNA topoisomerase IV subunit A; Provisional.	0
NC_015578.1\|WP_015707764.1\|1765961_1767353_-\|GntP-family-permease	gnl\|CDD\|225330	COG2610, GntT, H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism].	7.8434e-87
NC_015578.1\|WP_015707769.1\|1772024_1772750_+\|FecR-domain-containing-protein	gnl\|CDD\|377406	pfam04773, FecR, FecR protein. FecR is involved in regulation of iron dicitrate transport. In the absence of citrate FecR inactivates FecI. FecR is probably a sensor that recognizes iron dicitrate in the periplasm.	3.0662e-09
NC_015578.1\|WP_041611545.1\|1789259_1790291_+\|hypothetical-protein	gnl\|CDD\|349906	cd05656, M42_Frv, M42 Peptidase, endoglucanases. Peptidase M42 family, Frv (Frv Operon Protein; Endo-1 4-Beta-Glucanase; Cellulase Protein; Endoglucanase; Endo-1 4-Beta-Glucanase Homolog; Glucanase; EC. 3.2.1.4) subfamily. Frv is a co-catalytic metallopeptidase, found in archaea and bacteria, including Pyrococcus horikoshii tetrahedral shaped phTET1 (DAPPh1; FrvX; PhDAP aminopeptidase; PhTET aminopeptidase; deblocking aminopeptidase), phTET2 (DAPPh2) and phTET3 (DAPPh3), Haloarcula marismortui TET (HmTET) as well as Bacillus subtilis YsdC. All of these exhibit aminopeptidase and deblocking activities. The HmTET is a broad substrate aminopeptidase capable of degrading large peptides. PhTET2, which shares 24% identity with HmTET, is a cobalt-activated peptidase and possibly a deblocking aminopeptidase, assembled as a 12-subunit tetrahedral dodecamer, while PhTET1 can be alternatively assembled as a tetrahedral dodecamer or as an octahedral tetracosameric structure. The active site in such a self-compartmentalized complex is located on the inside such that substrate sizes are limited, indicating function as possible peptide scavengers. PhTET2 cleaves polypeptides by a nonprocessive mechanism, preferring N-terminal hydrophobic or uncharged polar amino acids. Streptococcus pneumoniae PepA (SpPepA) also forms dodecamer with tetrahedral architecture, and exhibits selective substrate specificity to acidic amino acids with the preference to glutamic acid, with the substrate binding S1 pocket containing an Arg allows electrostatic interactions with the N-terminal acidic residue in the substrate. The YsdC gene is conserved in a number of thermophiles, archaea and pathogenic bacterial species; the closest structural homolog is Thermotoga maritima FrwX (34% identity), which is annotated as either a cellulase or an endoglucanase, and is possibly involved in polysaccharide biosynthesis or degradation.	4.48568e-110
NC_015578.1\|WP_015707776.1\|1785387_1786329_+\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	5.78691e-114
NC_015578.1\|WP_015707777.1\|1786339_1787212_+\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	6.35478e-90
NC_015578.1\|WP_148257260.1\|1760425_1761556_+\|hypothetical-protein	gnl\|CDD\|224117	COG1196, Smc, Chromosome segregation ATPases [Cell division and chromosome partitioning].	0.00575378
NC_015578.1\|WP_015707779.1\|1788226_1789246_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|236898	PRK11308, dppF, dipeptide transporter ATP-binding subunit; Provisional.	6.31115e-125

>NC_015578.1|WP_015707770.1|1772724_1773690_+|putative-lipoprotein
MSVRNGLNELKKAIMGLAVLLFLASCDFLMGPPVEQGNVTIHTGRNGRAALTHDITDQFQYTFIFTGPEQHFEWTPAPGVSSRTLALDMGEWLVEVSAFNGNIVVGEGKERFTVVRGDNPVEVLMRETSRSIKIFNITSPVSAVGIVDEAAHTVAINVPYGTDVMNMVTSITHTGASIRPESGTEQDFTDAVLYTVTAANGSTQEYEVRVVILDRQEISITFTDPMDTNVGLTVSGMGLTYDDPTDTYTLLWLPPSVLRLTAAGGLEYQWHVDGIDSTGWVATASYDRQGNSFALGQHQIMVKIRTSAGAVYSETVNFIVD
>NC_015578.1|WP_015707769.1|1772024_1772750_+|FecR-domain-containing-protein
MKKYPASLLFIWVLAVPSMGLWAQNGAVSKARETTSQAAFIQEISGKVETKAPGSDWVSAVEGQMIENGTMISTGFKGVALIALGNSVLTVRPLTRLTLREIRENAGNEQVRLDMETGRIRADVSPPAGGRTDFMVRSPITTASVRGTSFEFDGTILIVAQGQVRFTGGDSTSVYVSAGHRVTINSMSGEPILVAEMIREEMKPDLPAGMSAAARGKEINPWKGTDLSAEGTVYVGTKWVE
>NC_015578.1|WP_148257262.1|1770758_1771997_+|hypothetical-protein
MGRRKTAVFWELILIFCASGGFGADFGVVVKTEPEYGSGSENFTLTGSVNPWVSALFSPAFNLYVSAGAYAEYTEQSLPFSREGFPLLIELERLELNWRPVPTVSFQLGRQQYGDPAGLIMAGLFDGLHGSWGFERLRFSLGALYTGLLYKKTANIAMTAHDLESYAAGTDYRDMTSYFASKRILVPVMVEFSDLSPRSSLALSVIAQFDMNRSDIEDDEAPLHSQYLEIQYLIEPREPLHITFAASAGLVEYGKPQMGFAAMVGADYEPPQAVKDLLSFQMRWSSGRMDSFFAPFFPVSNIAVGEIFTPRLTGLMQLKAAYSIRPHTNFSAEAGAGYFIRTDLETLQDANLDPALDSRFLGGELYCSLIWAPQSTLRLTAGGGAFFPGLGGAFASDTGIRWKASLGLMVSL
>NC_015578.1|WP_148257261.1|1770279_1770753_+|hypothetical-protein
MLKQTAPEPRICFLLATLFVLFISGGKIYAQTAAEIDRILESPEISSAQAAGFVQMAAGLLPDSDFLSIAGSRTPIKLGELCFLIMKSFNLKGSFLYTLFPGPRYSYRELRYMRLLPEPSDPAMRVSGLQLMQIVERVLNYLESDEKAALALNRGAK
>NC_015578.1|WP_015707766.1|1769419_1770199_+|methyltransferase-domain-containing-protein
MPEWFEDGHFWEHYGPIMFDRKRWDEVPLVADGLTRMARLDLYHRDTTGSSNTEQGPRVLDLCCGFGRIALELARRGFSVTGVDITETYLNTGREDASYEKLDVEFVKGDVRDFKRSGFFDLALNLYISFGYFENPADDLLFARNACEALKPGGSFIIETLGKEIAVRDFVEAEWFERAGYTVLTEYAPADSWAGLKNRWILIKGGERIEKVFTQRLYAGSEIRRLLFDAGFSSVELYGSWDEAPYDHRAEVLIAVGRK
>NC_015578.1|WP_015707765.1|1767502_1769419_+|DNA-topoisomerase-IV-subunit-A
MAYVKNLFDRNFLEYASYVIKDRAIPDLEDGLKPVQRRILHSLFEMDDGKYHKVANVVGHCMQYHPHGDASIGSALVVLANKDFFIDRQGNFGNILTGDDASAPRYIECRNTPLAKDIFYNPKLTPMADSYDGRKKEPILFPAKIPVVLVMGAEGIAVGMSTKILPHNIIEVLEAEKACLSGKKFELFPDFPSGGMVDVSEYRDGNGKVLVRAKLDTSDPKRIVIRELPFGSTTESLINSVETAAKAGRIKIQSINDFTTSAVEIEVKLARGVYSEETVNALFAFTECEQSISINLLVIKDNYPVVMTVTEVIKHHAKQLVKVLTRELELEKKELQDKLHLRTLERIFIEERIYKGIEKMKTAEGVTKAVIDGFKPFLKEIGSRGVSPEDVEHLLRIPIRRISLYDINKARAEMSEIQARIKEINNHLKNITAYALGFLDSIIAKVKANEELGKGARKTRVGKFDKVDVKEIVKKDLELKYDKGSGYLGTAVTGEVAAEVSPFDRILTLKNNGSWSVTDLPEKAFVGPGAWWIGVAEKEILSAIVFTVIYKDTDGHPCIKRCVIEGWIMNKDYSLVPEGAQVLHIDTREKFVFTLHYVPRPRLKILTEVFKAQNYAVRGLKAGGIRLSSKEVKKAEVK
>NC_015578.1|WP_015707764.1|1765961_1767353_-|GntP-family-permease
MTGIGLIIVFIIAIIVMILAISKLKIHPFLAIMAISLLFGLIGGIPLVNVTREDKSVVQGIANVIGAGFSGTFTSIGIVIILGALVGTVLEATGAAFKLADMVIKVVGPKHPVLAMQLMGWVVSIPVFCDSGFVILDPIRKALVKRTKVSSVAMSVALSTGLYASHVFIPPTPGPIAAANTLGVGNNLLLVMGLGVLVSIPALIGSTVFAQYIGKKVKSKEDIDIGGVTKTYEEIVAGYGKLPNGAISLAPIIVPIILMALGSIASMAKWAGSAFQISTFLGTPIIALAVGVLFAVWQLITANKLDKFYDITNETLKVVGPILFITAAGGVLGRVIASTDIVRFITTNSQALAAVGIFFPFLLSAILKTAQGSSTVALTTTAGIVAPLLGVLNLDSPARAALTVIAIGAGAMTVSHANDSYFWVVTNFGGMTPEQGYKTQTTATLIEGLCGMAGVFILSLILH
>NC_015578.1|WP_015707763.1|1763764_1765882_+|sodium-translocating-pyrophosphatase
MDERFFILVPIGSVIALIFAFIQGRKVLGFSEGSELMQKISRSIRQGANAYLKRQYTGVLLFFVVMFVVLGIMAFAGFLTPFVPFAFVTGGFFSGLSGFVGMKIATAANSRTTQASSESLDRGLRVAFSSGTVMGFTVVGLGLLDLSIWFFLLKYVFYANLAADPAEQVRAISAAMLTFGMGASSMALFARVGGGIFTKAADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDVAGMGADLYESYVGSIVATIALAVAAGYDYGGAAVPMIIASVGIVASLIGTFFVRCKENTDQKVLLAALRKGTYVSSAIIILAAYPIIYYFLDCAKHPERIGVYFAILSGLIAGVLIGFFTEYFTSQTYKPTKELAGSSLTGSATIIIGGISLGMMSTVLPAIIVGVSVLVSFFCSNGAQSFAQGLYGVGISAVGMLSTLGITLATDAYGPVADNAGGIAEMAHLPAEVRERTDALDSLGNTTAATGKGFAIGSAALTALALIVAYTDEVAIKAPDFIFNLNITNPPVLIGLFVGAMLPFLFSAMTMRAVGRAAQNIVVEVRRQFREIKGLMEGTADADYATCVDICTKGAQKEMIAPALTGIISPIAVGLILGVNGVVGMLAGATTTGFVLAVMMANSGGAWDNAKKYIEEGNYGGKGSDAHKAAVVGDTVGDPFKDTSGPSINILIKLLSMVSIVFAGLIIRFALFK
>NC_015578.1|WP_148257437.1|1761839_1763690_+|type-IIA-DNA-topoisomerase-subunit-B
MAPAKPAASKSSGSAVYDESKIKTLSSLEHIRLRTGMYIGRLGDGSNPDDGIYVLLKEIIDNGIDEFIMGNGKHIEIAVKDGTAKVRDFGRGIPLGKLVECVSVINTGAKYNDDVFQFSVGLNGVGTKAVNALSSHFRVLAFRNGEYAEAVFTRGGLVSQKKGKLKEKMKDGTYVEFTPDADIFGEYQFNLEFIEKRIQNYAYLNTGLNLHFNGKSYVSQHGLFDLLSEEIGEDGIYPTGYYKGEHLEFAFTHTSGDKHYGEEYFSFVNGQFTSDGGTHLSAYKEGFLKGVQTFFKKDYRSEDIREGITAAVAVKLKNPVFESQTKNKLGNSDIRTWIVQEVKDAVEDWLHKNQEAAKKLEIKIISNEKLRTELNAVKKEAREAAKKIALKIPKLKDCKYHLEDGIFGDKSTIFITEGDSASGSMVSSRDVMTQALFSLRGKIENMYGKKRAAIYKNEELYNMMMALGIENDTQGLRYARIVIATDADFDGFHIRNLLLTFFLSYFEELVTSGRVFILETPLFRVRTKKDTLYCYNEKERDQAVTNLGNQSEVTRFKGLGEISPKEFGQFIGEDIRLVPVSISVLKAVPQVLTFYMGKNTPERRDYIMKNLIDDAG
>NC_015578.1|WP_148257260.1|1760425_1761556_+|hypothetical-protein
MDERKKTIRELEEKRREVQSSIDGILQALGKNLLVRLDGENSGAFAQELGEYRRILGDIKESEESIREIEADTLHVKDLEGEINRKEQGNLEKNKELSELYTHLGGILLEKGEFASFDAPYRHQAEALVQKIQSLDERIGELDGAKNANIFAWIGKSTQGMVLRSLLTKSQAGLSKLYTAAGEKFASLNNQVLDNPALQDIMETVLRVRAEAAELGEALAKLRSEHREIGEALGQDGSPAKKTQELERHISHARGQLAALFLRVGGLMAAKKPGGEISEGESLSLSVDDMGALDKVGTLRGEIAEYEGCIEKLKASLAIDAAREEIEKMEKSITGHRQRIRASEEAIADLEKRIDESNQHIQKLMNMEYNKTPSGF
>NC_015578.1|WP_041611081.1|1777523_1780277_+|CHASE2-domain-containing-protein
MTIHKTSALVALGSSVIFFLLSLTPFFQQGENKVYDSFLRFRPKRERIDNVVFLDVDDLSVAHIGVFPWPRSIMADGLLRLKEYGADAAIFDIEYIDKSPTQVDEVYLRDGLRADYNRRFSQIGANVAELLNAVGAGYIPVKEAPAYIGDMMDLIADERDGLYRDTLAITRDNDEYLAQAAALFGKAWGTLNLQDEFPLTGEQAERRPLAEQRFSYPLTADEDVPVGNNIDILAAIPSFMSAVRGAGFTNVEIDSDGIRRRIFLTRKVGDHWYLQLAFAPLMEYLGYPSIELHPRKLIIKGAEAGDRVIPLDSAGAMLLDWPTASYRDSYSHISFLRFSLLTEYEAHIEQYLDALLFADRHLFPHIVENSGTLAAILNNANDERSRAVEGTDEASFAKYMVLRDQGLVQLEEFLDGAGDYLETETLGFLENPGGLDPEYIRQEAEYCQNLLEYLQTELKALEETRGYLRENLAGKLCIIGRVDTGTTDIGVNPFHGEYVNVGTHAVVLDTILSSSFITPLPSFWSILILFLLGPLVIISISNVTPGLRFLLGISADLLFFIFSFCLFYFKGIFLAPLNPALALITALVLRETLAYVGTEKEKKFIRSAFSRYLAPKVIEQIIADPSKLQLGGQKREMTAMFTDIRSFSTISEALGDPAMLVQLLNFYLTRMSNIVMEHQGTIDKYEGDAIIAFFGAPLELPNHAVMACRSAVEMKKAELAINRDAISEGLVTEAAIEALLKKGIITESGRSEPVFTRIGLNTGDMVVGNMGTPNKMDYTIMGDAVNLAARLEGVNKQYNTRGILISEYTRAQIGEEFLLRRLDRVRVVGKNEPIRLYEIVDMADAASAEDAKRVGLFNAALDFFENRDWAAADEGFQAVLEMAPLDGPGLIYRKRCAAFRKKTADDNWDGVFNLDEK
>NC_015578.1|WP_015707773.1|1780315_1781971_+|2,3-bisphosphoglycerate-independent-phosphoglycerate-mutase
MVEALKKNPAWKGRKGPVVLVIMDGVGYGKYKEGDAVADSKMYHLDAIRAKSPNTKLKAHGKAVGLPSDEDMGNSEVGHNAMGCGRVFNQGAALVSTSIETGALFQGHAWKEVAATKGTLHFIGLFSDGNVHSHLDHLKAMIKQAKADGVKKVRVHTLFDGRDVGETSALEYIDPFEAFLKEQSTGGFDARIASGGGRMWITMDRYGADWSMVERGWKVHVHGEGRQFASAREAVESYRKEIPGIIDQDLKEFVIADGGKPIGAIQDGDSVVYFNFRGDRSLEITAAFEDDKFDKFDRGRRPAVTYAGMMEYDGDLHAPKRYLVSPPSIDRTMGEYLAATGVRTLAISETQKYGHVTYFFNGNRTGKFDDKLEDFVEIKSDVLPFEQRPWMKCAEITDRILEAIPSGKYDFIRLNFPNGDMVGHTGVYQAVICSMEAMDLQLGRIAKAVDEAGAVLVITADHGNSDDMFEHDKKTGAVSRKADGSPKAKTSHSLNPVPCIIYDPGYQGEYKREPHEGSLVEGLGISSIAATCIELLGYTPPEDYDKPVITR
>NC_015578.1|WP_015707774.1|1782154_1783702_+|ABC-transporter-substrate-binding-protein
MKKGFLLVLVIALGLQGLYAGGSKQGGTASSAKTVTIGCNVNTPYGTLDPVHEDGTILWIIELAFEGLVDTVETAGGGVALAPALADSWEISADGLFYTFHLKPGVKFADGTPVTTADWIWSFERARDTPESPWASYAEPIKAITAPNANTLVIELKRLNAPFLSMLAVHNFSVQSKARFDKLGADEYFKHPLGTGPFYFTDWGLHEYYRLEKNPYYYGGVSKVDVLQFNVVEDDNTRIMQLQAGDIDVCLNPPANRIAELQADKNIDVEIVNSTEQRYVNFNTTKPNLNNATVRRALRMATNKNEIIKMAVFGYGEPTYIVYPRIIGEFFNTDIVDEGYDPVKAKALLTQAGFPNGFTTEISYSNGNSVVEGIATLLKAQWAQIGVTLNLTPMEGAALSEQFDTLNHTITMLRWSEDTNDPAGLTDFIAVYDQSHGFHTGFKNSRMTELAEIAAGTVDTAKRAAAYKEIQKILYDEAPLFPVYQASYFLATRKNISGFKQLSLGQYDLSELVKN
>NC_015578.1|WP_015707775.1|1783745_1785296_+|ABC-transporter-substrate-binding-protein
MKRYFGLLALILVIGLQGLYAGGNSQSSRNAANAANTITIGCNIDSSTLDPVLEGGTILWIIELGFETLVNIEETSDGGMELVPVLADSWEISDDGLFYTFHLKPGVKFADGSPVTIADWIWTLERARDTPESPWASYAEPIKNISSPGANTLVIELKRLYAPFLNMLAVHNFSVQSKTLYDKVGPEAYFKKPLGTGPFYFTDWDMHESYRLQKNPYYHGKAPKVDTLQFNVVQDDNTRIMQLQAGDIDVCLGIPSNRVTQLQSDPNLKVDIVDSSEQRYVNFNVTKAPLNNVKVRQALRMATNKDEIVKMVLFGFGEPTYLVYPRIIGQYFNTAIKDDGFDPVKAKALLAEAGFPNGFTTEISYSNGNTILENISTLLKAHWAQIGVTLNLVPLESAALSEQFNSLNHTITMLRWAEDTNDPAGFTDFIAIYNQSHGFHTGFRNTRLTELAGIAAGTVDTSKRAAAYKEIQQILYDEVPMFPVFQTAYFVVTRKNVSGFKLNSLGNYDLSELTKN
>NC_015578.1|WP_015707776.1|1785387_1786329_+|ABC-transporter-permease
MNRLNYILKRLLQMIPVLFVITVVVFLLIHFIPGDPARLLLGERAPISSVEAMREKLGLNQPLIVQYGIFMHNLAHFDLGVSIKYHTPVMELLGRRLSLTVALTLLSCLFAALVSLPLGYIAAVNKDKLPDQIIRGGALIALSVPTFWIALLLLIVFALRIRIFPIGGWGSTPLEHLRGLILPAFTLSLSTSALIMRNARNNIVDTARSDFVDFARSKGLKNNTVRMRHIIRNGLVSSVTLLSMQVAAMIGGSAITETVFNLPGIGKLMVESIFGRDYPVVQGTLLVTSFLIMSVNLLTDILYSALDPRVTLD
>NC_015578.1|WP_015707777.1|1786339_1787212_+|ABC-transporter-permease
MGITLADIREAGLRRKKPLSPALRNTNIVIGGVIVLVMVFIALFPGLVASHDPLAYSADLMLRPPSAEHIFGTDHLGRDIFSRVIWGARIDLMMGVVAVITPFILGTLIGLLAGYYGGFMDSLMMRACDIFMAFPFTLIVIVVVTVTGPSITNLFIAMWLVSWMHYARLVRGEVLVAKNAEYIQAARVLGYTNIRLLLRHLLPNVISGCVVYAASDIVMCMLAGASMSFLGLGIQPPTPEWGAIIEGGRAYISNAWWIAAFPGLFLAVTGTGFSLIGDGLSDLLRTRGRA
>NC_015578.1|WP_015707778.1|1787213_1788230_+|ABC-transporter-ATP-binding-protein
MEELLRVQNLCTSFFSGGAVIKAVNDVSFTVMQGETFGLVGESGCGKSAICRSISRLIRDPGKIMGGQIIYRGTDIMGLQSEAMRLLRGREISMIFQEPMTALNPVIPIKTQIYETLDPALSGNEKRDRTIELLRLVGIPHPEKRMHEYIHQFSGGMRQRVMIAIALASNPKLLLADEPTTALDVTIQNQIMELINSLREKLGMSLILVTHDLSVVSQMCDFVAVMYAGRIMELCDTVTLFTAPRHPYTYGLLNSIPSNASVRLEPIAGSPPNLADPPPGCPFAPRCKFKEDICDTTVPELLEIESRHSVRCHFSQKLEGLSGLIETEKSAEQEGPEA
>NC_015578.1|WP_015707779.1|1788226_1789246_+|ATP-binding-cassette-domain-containing-protein
MNSNTLISVRGLKKYFPLKRQILDALAGKPLESLRAVDGVDLDIQEGETLGLVGESGCGKSTLARTIIRLYKPDEGDIIFRGVNLARLGERSLRPHRKNLQMIFQDPYSSLNPRMSVHDTLAEAILFHKICAKDQMEAKIREVMDMVGLTQDAAERLPSEFSGGQRQRIGIARAVILNPQMIIADEPVSALDVSIQAQVINLLSDLQSRLNLTMLFISHDLRVVRHITGKVAVMYMGRIVELSSTKGLFEKPLHPYSDVLLRAEPGLDPRLRTREIVIKGEPPSPINLPRGCRFHPRCKFRQKECQEREPSLAEAAPGRMVACHYPLNIQGSFPYQHVY
>NC_015578.1|WP_041611545.1|1789259_1790291_+|hypothetical-protein
MDIQKTLFELCRLWGPSGFEEKVSAHCAAILGEYTRDVKTDRLGNVLASIPCGKTGARKVLVDAHVDEIGMIVSGIEEGFLKFETIGGVDPRMLPGREVVILTEDPLFGVVSCLPPHVLTAEQMEKPIPVKDMFIDAGFSDEEARKRIPIGTPVVYRDEPRALENRILSGKAMDDRAGFVALVQTLELLKGRALGVDLLVAAGAQEEVGMRGAGPLAYAVSPDYAVIVDVSHAHTPDSKGQTSCKFGGGPSIGIGPNTDRRFTQYIRDTAVSRDIPHQLTVHTRNSGTNAFPVQVARAGVITAMVEIPTRYMHSPVECLMIDDIENTAKLIAAVLEGMDGEGF
>NC_015578.1|WP_015707781.1|1790292_1791318_+|M42-family-peptidase
MSIIALLRELCTLDGVSGMEAEVRDYIIKKAKPHAEELQVDPLGNVLVLRKGKKRPEKRVMLCAHMDEVGFIIKDISPEGLLKFSALGGIDRRVILGKRLKVGPKKLPGVLSIKAYHLVDKEEEKVSPKIDDLFIDIGAQSREEAEKLVSIGDICSFDSDFVEFGNGFVKAKAIDDRIGCAVMLRLIEEEPAVDTWFAFVTQEELGLRGSPGAAFAIHPEIALILESTTAADLPSVEGHRKSCSPGKGAVLPFMDNSAIYDHAMFDDLRRIAIEKGILWQYKTIVAGGTDAGSIQRSHEGVQVAVIAAAVRCIHSPICIAYAPDFEEILKLARAYLEYLGE

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Crispr_ID: NC_015578_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015578_10

2103399-2103665

Orphan

Consensus_repeat	Method
AATGTCGGCGGCGTGGTGGGG	PILER-CR

3 spacers

The CRISPR arrays of NC_015578_10

>merge|NC_015578|10|2103399-2103665|PILER-CR
CCCCGCCACGCCGCCGACATTATCTCTGCCAGTAACGGGGCCGATGTTGGAGCAAGCGGTGACGCTGCCGCCTTCGATGTACCCCACCACGCCGCCGACATTTTCGCCAGTGCCGGAAACGGGGCCGGTGTTGGAGCAGGCGGTGACGCTGCTGGAGGAGTAGTTGTGCCCCACCACGCCGCCGACATAGTTGCTGCCGGAAACAGAGCCGGTGTTAGTACATGCGGTGATGGTGCCTTGATTATACCCCGCCACGCCGCCAACATT

>NC_015578|10|3|2103399-2103665|PILER-CR
CCCCGCCACGCCGCCGACATT	ATCTCTGCCAGTAACGGGGCCGATGTTGGAGCAAGCGGTGACGCTGCCGCCTTCGATGTA
CCCCACCACGCCGCCGACATT	TTCGCCAGTGCCGGAAACGGGGCCGGTGTTGGAGCAGGCGGTGACGCTGCTGGAGGAGTAGTTGTG
CCCCACCACGCCGCCGACATA	GTTGCTGCCGGAAACAGAGCCGGTGTTAGTACATGCGGTGATGGTGCCTTGATTATA
CCCCGCCACGCCGCCAACATT

Protein	Signature genes	Signature genes Name	Protein_function
NC_015578.1\|WP_015708066.1\|2114668_2116156_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015708053.1\|2098162_2099140_-\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015708065.1\|2113813_2114665_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015708060.1\|2105925_2108499_-\|GLUG-domain-containing-protein	unknown	unknown	gnl\|CDD\|223021
NC_015578.1\|WP_015708064.1\|2113360_2113807_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_041611111.1\|2101845_2102703_-\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015708050.1\|2095891_2097373_+\|glycogen-synthase	unknown	unknown	gnl\|CDD\|234809
NC_015578.1\|WP_015708067.1\|2116165_2116393_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_169313414.1\|2100859_2101591_-\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_148257275.1\|2100131_2100428_-\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_148257445.1\|2099450_2099774_-\|SARP-family-transcriptional-regulator	unknown	unknown	unknown
NC_015578.1\|WP_015708055.1\|2099858_2100074_-\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015708051.1\|2097428_2097848_+\|nucleotidyltransferase-substrate-binding-protein	unknown	unknown	gnl\|CDD\|378048
NC_015578.1\|WP_015708052.1\|2097838_2098141_+\|nucleotidyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|143393
NC_015578.1\|WP_148257276.1\|2108508_2110230_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380138
NC_015578.1\|WP_174269882.1\|2116910_2117312_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_148257277.1\|2110233_2111613_-\|OmpA-family-protein	unknown	unknown	gnl\|CDD\|143586
NC_015578.1\|WP_015708068.1\|2116392_2116914_+\|C40-family-peptidase	unknown	unknown	gnl\|CDD\|223862
NC_015578.1\|WP_015708049.1\|2095398_2095815_+\|ACT-domain-containing-protein	unknown	unknown	gnl\|CDD\|227090
NC_015578.1\|WP_015708063.1\|2112720_2113329_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274035

Protein	Function_ID	Function_description	E-value
NC_015578.1\|WP_015708060.1\|2105925_2108499_-\|GLUG-domain-containing-protein	gnl\|CDD\|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	0.00272922
NC_015578.1\|WP_015708049.1\|2095398_2095815_+\|ACT-domain-containing-protein	gnl\|CDD\|227090	COG4747, COG4747, ACT domain-containing protein [General function prediction only].	2.96891e-44
NC_015578.1\|WP_015708052.1\|2097838_2098141_+\|nucleotidyltransferase-domain-containing-protein	gnl\|CDD\|143393	cd05403, NT_KNTase_like, Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins. S. aureus KNTase is a plasmid encoded enzyme which confers resistance to a wide range of aminoglycoside antibiotics which have a 4'- or 4''-hydroxyl group in the equatorial position, such as kanamycin A. This enzyme transfers a nucleoside monophosphate group from a nucleotide (ATP,GTP, or UTP) to the 4'-hydroxyl group of kanamycin A. This enzyme is a homodimer, having two NT active sites. The nucleotide and antibiotic binding sites of each active site include residues from each monomer. Included in this subgroup is Escherichia coli AadA5 which confers resistance to the antibiotic spectinomycin and is a putative aminoglycoside-3'-adenylyltransferase. It is part of the aadA5 cassette of a class 1 integron. This subgroup also includes Haemophilus influenzae HI0073 which forms a 2:2 heterotetramer with an unrelated protein HI0074. Structurally HI0074 is related to the substrate-binding domain of S. aureus KNTase. The genes encoding HI0073 and HI0074 form an operon. Little is known about the substrate specificity or function of two-component NTs. The characterized members of this subgroup may not be representive of the function of this subgroup. This subgroup belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, co-ordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are conserved in this subgroup.	6.87976e-08
NC_015578.1\|WP_148257276.1\|2108508_2110230_-\|hypothetical-protein	gnl\|CDD\|380138	pfam18657, YDG, YDG domain. This presumed domain is found in a wide variety of bacterial cell surface proteins. This domain has a highly conserved YDG motif near its N-terminus. This domain is likely related to the pfam17883 domain.	6.89502e-08
NC_015578.1\|WP_015708050.1\|2095891_2097373_+\|glycogen-synthase	gnl\|CDD\|234809	PRK00654, glgA, glycogen synthase GlgA.	0
NC_015578.1\|WP_015708068.1\|2116392_2116914_+\|C40-family-peptidase	gnl\|CDD\|223862	COG0791, Spr, Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane].	0.000732902
NC_015578.1\|WP_148257277.1\|2110233_2111613_-\|OmpA-family-protein	gnl\|CDD\|143586	cd07185, OmpA_C-like, Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA. OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.	1.39656e-21
NC_015578.1\|WP_015708051.1\|2097428_2097848_+\|nucleotidyltransferase-substrate-binding-protein	gnl\|CDD\|378048	pfam08780, NTase_sub_bind, Nucleotidyltransferase substrate binding protein like. Nucleotidyltransferases (EC 2.7.7) comprise a large enzyme family with diverse roles in polynucleotide synthesis and modification. This domain is structurally related to kanamycin nucleotidyltransferase (KNTase) and forms a complex with HI0073, a sequence homolog of the nucleotide-binding domain of this nucleotidyltransferase superfamily.	1.33956e-18
NC_015578.1\|WP_015708063.1\|2112720_2113329_+\|hypothetical-protein	gnl\|CDD\|274035	TIGR02215, conserved_hypothetical_protein, phage conserved hypothetical protein, phiE125 gp8 family. This model describes a family of proteins found exclusively in phage or in prophage regions of bacterial genomes, including the phage-like Rhodobacter capsulatus gene transfer agent, which packages DNA. Members of this family show some similarity to members of pfam05135, a putative DNA packaging protein family. [Mobile and extrachromosomal element functions, Prophage functions].	4.2136e-05

>NC_015578.1|WP_041611111.1|2101845_2102703_-|hypothetical-protein
MMNGKRKAIGVRYLFCGIGFALVGKFLRNLLGVSAVPKLQLWALGFVLALAGCAAPVGGPEGGRLGTVRVEVSGFEVSGPQRTAYPTPPLPSGLTYTYTWMAIEGSPTPVKADRDSSGNFILAAGSYTLDVKAYVGYEDDANLVGTGVGNVSGSTTITVTNDTTVTVTVTLKPVDGRIETSDGTLKYTIKYPAGTTVLSLTLQNFEGGDEVNLTPSAIPSSTLTGTKTGLAAGEYLLRAELKNSANGTAGMSETVHIYGNMTTTVPPTSPAPSAASFVFTAGDFI
>NC_015578.1|WP_169313414.1|2100859_2101591_-|hypothetical-protein
MKVIESNRNHVLSNMHDRKVFCHKGCNLCCHSLSLTVDTLSSYILSKVFEAIPYNELFPFYKKCIDKRIKARAYIDSLPVDTNRNDTLEEYATFGFTVFTCPFVDEQNGCLIYTFSPQICFSYFSSVQCKISYNPVIDENQKLLYEQLGSKAETIDFSGLDNDSKEFHFDDTTFKTYDKFDNLSKTIKQDPNLEYFLSHSMKLEILTIISMALEKTHPGKYKSDMQGIEVDLLAIIDGEMKSL
>NC_015578.1|WP_148257275.1|2100131_2100428_-|hypothetical-protein
MPDYRHLLYAGDSAPAIHTPKQYYCASVLVFPCHHSRVHCCPFVSPVRAQALPPPSLSSYGNYYTLKRYFHRRTTAQQWASQVVATHAIGPGGQLSMF
>NC_015578.1|WP_015708055.1|2099858_2100074_-|hypothetical-protein
MLQLEDDPFFDGFEQGRIEGYEDGVISVYDEFELKFQEIARQFHRCGLDIDQIMSITGLEEEEVEEALEAV
>NC_015578.1|WP_148257445.1|2099450_2099774_-|SARP-family-transcriptional-regulator
MDDNQNLTQAGVNARRSVPAATKAQGKTFTAYKPYTPQFSAAATVTVRRLAWALGCSMPAAVSRLVELLPSLYAAETVCSHCQDKEKCSLCSFKTAAPTPPKDLIYL
>NC_015578.1|WP_015708053.1|2098162_2099140_-|hypothetical-protein
MRNFPQKKPGSGKSLLSRGLSRRFRLGAALAFLALAGILFFALTRPTMTWYVEEELESPWRQVLAAGTPPRGFKGIQSLKPGEAPPAKAKGFLITRKRAELAEPVMVYPRLSFDLEYQGALVLALDPWMVFRNNNFPGLTRQRVESAGEGTLLIPGSDPAAVQAWTARFLERPEGEFPRDGDIWQSTGEALFRRAPFPRGAATFNWPDIWQVLLGKETSWVYAPLSRVRDLPANRSSILEASVFPGPGDNRFGLQAEILWAIPLGKPGKLEKAATWLKSGPAQTLIADTLRWLAASPDAKPFNPVVMSARNAWLTCSYVWECGEW
>NC_015578.1|WP_015708052.1|2097838_2098141_+|nucleotidyltransferase-domain-containing-protein
MDLKDVAMQQKDRDLLSALVGEFLPHTAVWVFGSRIKGTSLPYSDLDLVVFTNPEQQQQVSLLKEALEESNLPFRVDVLEWNAIPESFKETIKTKYAVIA
>NC_015578.1|WP_015708051.1|2097428_2097848_+|nucleotidyltransferase-substrate-binding-protein
MIDYGKLKKSLTHLILQYRNYTSLAERAGLLEIDREAVAESVIQRFEVCYDCLWKLLKRYLGEQLGIAELPNSPKPLLRIAFENRLFPSIEQWLRYADARTGTAHDYSGDKAGETLKLAGPFINDAIALYQIMAGEPWT
>NC_015578.1|WP_015708050.1|2095891_2097373_+|glycogen-synthase
MKILMASSEAVPYAKTGGLADAVSALSITLAKLGHEVKLVIPRYYGIDRGALTLIPEAMGVPVGGGEEWCAVYTTDLEGSPKKNPVTVYFIDHEKFFGRDGIYGTPSEPDFLDNPRRFTFFSRSVFQLCRKIDWYPEVLHAHDWPAAMVPVFLKFGERREGFAKTVSVLTIHNLGYQGIYSKDNYWYTRLGWNEFYTAGFEDWSMMNLLKAGIYSADKLNTVSPNYAEETKTSAQGFRLDGALRYRAADYTGILNGIDSQLWNPKTDTLLPAKYNPKDMSGKAKNKEALQKEYGLHPDPKLPIIGMITRLTGQKGVGALFGPAYGSAFSICRDMNLQFVLLGSGEAWCENELQSLSGRLSNFKARIGYSEDISHLIEAGADFFLMPSQYEPCGLNQMYSLAYGTVPIVRSTGGLADTVSNFHEETGEGTGFMFNDLTPSAIYNTVGWAVWAYYNRRPQIEAMRLRGMQQDFSWEKSAKKYLDMYESALTPSTK
>NC_015578.1|WP_015708049.1|2095398_2095815_+|ACT-domain-containing-protein
MQIKQISVFLENNAGRLADVTKVLAEAAINIRAISIADTADFGILRLIVDKSDAAISALNKAAFTTRLTDVVAVEIGDTPGCLAKVMELFQKSKVNIEYLYASLEGKVGKAVVIFKLENLEQGLKIITDNGLSMVDKF
>NC_015578.1|WP_015708060.1|2105925_2108499_-|GLUG-domain-containing-protein
MSKIVKGFMPVFPAFGALLAALALSCANPASPPPQAPGGTAQVRFAPGFGSSAQASPALRSSPALQAGPGRTVFPSAPAPAGLFPAYTFTKGGESKTPAADGDGVYTLETGDWAVTAKAYLDADHEQLVGESIATPFTVSAEAGVQNIPILLRPIADSGQGAIDYAISYPATATLVALTLAKAGGGTAPDLSPYTDDGAGQRTHGAPNLPAPAGYYDLTVRLVDSLGRTAGKNDVVHVYQNMKTTIPAADWTFTDADFTALLVETAAVTNLVAPVTGKAPAILSSLSVAGGAHYTVTGLTWKLRSGSSPTYTWTDFSGNFVLATYRAAITLKADSGYKFSATPTVNTTSGGTVGDVTLSGDTAENTLTFTVSFPATSGDIAKVEPEWDIPKPQTLAINKSRDTDWISAAGTLTLTLTGSGYSDIQWTVNGSPVAADDPAYIFKGAGRSLGTYTVGVQAKTTDGRWYENWVTITVFVIEAKLVLEGDYLGGITAVVEDGLLKSITPTGKDPILIGRKADEPVTLNLGADGKLQFRTAVSGSIPIGSYGEFQLIRTASGGLSGKYKQEADLDLMGIPPASKGSAWSGQQWTAIGASSSAAQFKGTFDGGGKAISNLFISNTSADDQGLFGYVGQNGTVQNVHIASGSVTGRNRVGGVAGENRGAIIDCSNSGDVTGTNSNNGVGGVVGTGLEFSTITACSNTGNVTGTGTYYSISVGGVVGYLDQGVTVTACYNTGDVICTTPSPNVGGVVGRNWNTNVTACYNIGAVVASGSNVGAVVGNKNSGSTTACYWIERTDVTGSTSSDGGGTKFGEGDAWPSNDASAQWAIGNHDGTSGNYWKSLGGWNSGRPVYPKLWWEK
>NC_015578.1|WP_148257276.1|2108508_2110230_-|hypothetical-protein
MKTKQIAQWRPKWRQAPFLALVLLGVAGCGNPILRDIWSTEPKPGAQGPLVDPVTDTTAPGLPSGRAIDQASAAGTTATIKFSADEGGTFYYIVLPEADSAPSPQTIQADGASGTAVVGINAILLEGLAAGAGYTVYIVVADAAGNLSAILDIPVSPRHTGANPAKDRSEQNEAALIAAGEITLTAPRAGGGSAQVGITLGEDGRITIVIDGVPREYPYTITGDTIIVAGGGSGGGDAELGFAIGDDGTLTLVGLDKLADGGLAPGAVVSDPNPLLIPPPASILGVAAPSFDGAVYGGERPGAKTITITNSGTADAAISSVALSGDGKDAFVLGGSGDAVSAGGSIATRTVQPAAGLAAGTYAATITVSYDGGAAATAALTVTVVPRPLTATATATDRVYNDTKTVTVTITPTNKVGSDDVTITATGTMADTAPGNDKDVAISNIALTGAAAGNYTAPGSIANTTVTIYPAGKPGITAWVANHAIVTDLPGNTAALSRAGAGGTAKTLPVTVTGGGSGDSYQWSIGGVVQEGETGASYTFDSAGRDTGIYRLTLRVVQGGVPYTTTISITVEE
>NC_015578.1|WP_148257277.1|2110233_2111613_-|OmpA-family-protein
MAFGPGLAGEYRFSPALAAGVSLGFFYDFTDYSTFEPGAFLRWYPLAKTAGPLSGLFAQGMGGAAFMWGSDDMKTMLMGGLELGLRLNLGKGGWYVEPRIRGGYPFIAGAGVAAGWRPKKNEELKAARQEAKAKRQAEIVQRQEAAQEAAQQEAEAKRQAEAQRQEAARQETARQEAARQEAARQEAETKRQTEAQRQETARQEAETKRQAEIVQQTEAQRQEAARQEAQRQETARQEAARQEAQRQETTRQEAARQEAARQIAARQEAARQEAERQQAEAERQVETQRQAEAQRQAEAQRQAEAQRQAEAQRQEAARREAARHVAGVPSEDIAESVALADGRRGFALRITVPFVADLSSLGPGAAGRLREIGETLKGFPDSRVVIQGHTALAGTPGARAQLSRERAEAAADFLIAGEYVRRDQIELQALGAEQPLDSNMTYAGREKNRRVTIIILQGE
>NC_015578.1|WP_015708063.1|2112720_2113329_+|hypothetical-protein
MGITPKQERLFSLVPLGDFKALLGIDDREDALARYCLVTASYTIEEYCRRRLLCRKRTEFLHYSGDPVIPLGDYPVRKILAVYKIGRQGEEPILPGLYRTVPECGPEDIPFCLSVDPAAGLERRVVAIRALYLAGYRQGEVPADLASACLELAAWNMSRFRGKRIGMAGAAVRGKAGVGEYLEASMPENVKALLEPYRRRML
>NC_015578.1|WP_015708064.1|2113360_2113807_+|hypothetical-protein
MDYTEDTILRGVKRVLAGAVNELLDEEQDNIPRIEFPGPVDGYLALSRLSGSVCPDISLLGGERTEKDRIIGLEVFDLAITFFVPELDGEQNCYAYAAAVTGALEDDPTLGGVADRAVVVKKKYTPPRTGIFVDGWEAVLTVRVFVEK
>NC_015578.1|WP_015708065.1|2113813_2114665_+|hypothetical-protein
MVNGRDCVIAIGTVPVPYAEETIREAVAALIEQASIEGDGVCRGIQKNCGVTGCIVTPLTIGTAPLLLGLALGEAGIPVFVSETRNLYRRELRLVPYEDGERFELCQERGERGKRFEACGVSGFELRIHQGEAVKLRLDIAGEHGGAPYPSEGGREFATGERFKENGVSYTVNGRELREIYGLTIAAKKIGGTKTEVWIHRVLEESADIPQAIEKLEVTARLYRDRYEQGNQGSGNLGLFRLRLSRLVMMSDETAVDAADAVIGPLRYYCAGDFTAEVFSEGN
>NC_015578.1|WP_015708066.1|2114668_2116156_+|hypothetical-protein
MRFYAIDDSLKEAIDKGTAAVKVRVEIERGGHFEAVFERDIIEASFYGLKEVAGGTSARGEVLLDNPKGMYSAENGAGREVRVSFSIGEGLPWFQRFTFFVDGKGFQDIRGPGRVRRVLLGLRDRSAFLRRTDESRDWTQPAVFTYSVICDKTQPEKSLVHRIAKRAGLAVQDIDCATIPVTLPYVKLTKNTWAELSALATAYRCHLECPVEKPLVFAHSPYQDEPLSADDENPSYTFTGVDIFYLRVTERADQYRNTVRLKINIPVALEKQEIWRYEDPPVLYDSSLAPVYPFRGSALRDIEQYDYEALYTVKDSKGAERRVIFADQIDTIEEAQERLSYEGGPFVYSAYDTTTHHDKAIITLGSDNDGDLFKASIFGRPIVLDVNRSAFLRDSNAVTLHGTCALNVTGSYFSEDVFNGRPQYEDWTAQELAERLQERREITVKTHRALFHGRVGARVKIETRDGTAKGTVNAFSLRYKRDAAFVAAFKVTVTT
>NC_015578.1|WP_015708067.1|2116165_2116393_+|hypothetical-protein
MGEELQRLLVDTIAEMRELKGELREFKKHVMGRVEKLEKKEGERRGDLKATVSVLIAAAALAVSIIVNFFRHGGK
>NC_015578.1|WP_015708068.1|2116392_2116914_+|C40-family-peptidase
MGIKWDKVFENEQRQFEKMTEAEKFIYFLLLQFNSPYGWGKENPELSDCSGAVCLALFAATGHFIRTTADDLYKRVFTAQRPSPDGIKAAFFVDGKTGAASHVAGLVGDGVVLNSQEGGARVRSLDFLSAWFWNRGSSTAIRGLDRAALVRLSHEGSRYDVDPELRRYMEIAL
>NC_015578.1|WP_174269882.1|2116910_2117312_+|hypothetical-protein
MSDSDGIQISDKASWEHSEKELLVILGKRLIALPSKMLGFKPFCLYLATWLLVKGLIRDWIWFAVMVMVLFGIVGLKVIARSGIRNEEGGSRNGGFLAGGGCRGGGGSAGGGDGVCGDSAPGTGPGDYRTMGG

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Crispr_ID: NC_015578_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015578_11

2111927-2112091

Orphan

Consensus_repeat	Method
CAAAAAGGAAAAAGGTGACTGTCACC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_015578_11

>merge|NC_015578|11|2111927-2112091|CRISPRCasFinder
AAAACGGCAAAAAGGTGACTGTCACCACTTTTGCCTAGTGTCGCCGGTGCCCAAAAAAAAGGTGACAAAAAGGAAAAAGGTGACTGTCACCATAAAGCAAAAAACAGGGCTGCCCCATATAGCTATCAAACGGTGTCATCAAAAAGCAAAAAGGTGACTGTCACC

>NC_015578|11|8|2111927-2112091|CRISPRCasFinder
AAAACGGCAAAAAGGTGACTGTCACC	ACTTTTGCCTAGTGTCGCCGGTGCCCAAAAAAAAGGTGA
CAAAAAGGAAAAAGGTGACTGTCACC	ATAAAGCAAAAAACAGGGCTGCCCCATATAGCTATCAAACGGTGTCAT
CAAAAAGCAAAAAGGTGACTGTCACC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015578.1\|WP_015708066.1\|2114668_2116156_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015708053.1\|2098162_2099140_-\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015708065.1\|2113813_2114665_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015708060.1\|2105925_2108499_-\|GLUG-domain-containing-protein	unknown	unknown	gnl\|CDD\|223021
NC_015578.1\|WP_015708064.1\|2113360_2113807_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_041611111.1\|2101845_2102703_-\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_174269888.1\|2117350_2117737_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|235334
NC_015578.1\|WP_015708067.1\|2116165_2116393_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_169313414.1\|2100859_2101591_-\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_148257275.1\|2100131_2100428_-\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_148257445.1\|2099450_2099774_-\|SARP-family-transcriptional-regulator	unknown	unknown	unknown
NC_015578.1\|WP_015708059.1\|2102792_2105747_-\|peptidase-A26	unknown	unknown	unknown
NC_015578.1\|WP_015708055.1\|2099858_2100074_-\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015708063.1\|2112720_2113329_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274035
NC_015578.1\|WP_148257446.1\|2118431_2120354_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_148257276.1\|2108508_2110230_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380138
NC_015578.1\|WP_174269882.1\|2116910_2117312_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_148257277.1\|2110233_2111613_-\|OmpA-family-protein	unknown	unknown	gnl\|CDD\|143586
NC_015578.1\|WP_041611113.1\|2117733_2118285_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015708068.1\|2116392_2116914_+\|C40-family-peptidase	unknown	unknown	gnl\|CDD\|223862

Protein	Function_ID	Function_description	E-value
NC_015578.1\|WP_015708060.1\|2105925_2108499_-\|GLUG-domain-containing-protein	gnl\|CDD\|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	0.00272922
NC_015578.1\|WP_015708063.1\|2112720_2113329_+\|hypothetical-protein	gnl\|CDD\|274035	TIGR02215, conserved_hypothetical_protein, phage conserved hypothetical protein, phiE125 gp8 family. This model describes a family of proteins found exclusively in phage or in prophage regions of bacterial genomes, including the phage-like Rhodobacter capsulatus gene transfer agent, which packages DNA. Members of this family show some similarity to members of pfam05135, a putative DNA packaging protein family. [Mobile and extrachromosomal element functions, Prophage functions].	4.2136e-05
NC_015578.1\|WP_148257276.1\|2108508_2110230_-\|hypothetical-protein	gnl\|CDD\|380138	pfam18657, YDG, YDG domain. This presumed domain is found in a wide variety of bacterial cell surface proteins. This domain has a highly conserved YDG motif near its N-terminus. This domain is likely related to the pfam17883 domain.	6.89502e-08
NC_015578.1\|WP_174269888.1\|2117350_2117737_+\|ABC-transporter-permease	gnl\|CDD\|235334	PRK05035, PRK05035, electron transport complex protein RnfC; Provisional.	0.00548632
NC_015578.1\|WP_148257277.1\|2110233_2111613_-\|OmpA-family-protein	gnl\|CDD\|143586	cd07185, OmpA_C-like, Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA. OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.	1.39656e-21
NC_015578.1\|WP_015708068.1\|2116392_2116914_+\|C40-family-peptidase	gnl\|CDD\|223862	COG0791, Spr, Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane].	0.000732902

>NC_015578.1|WP_148257277.1|2110233_2111613_-|OmpA-family-protein
MAFGPGLAGEYRFSPALAAGVSLGFFYDFTDYSTFEPGAFLRWYPLAKTAGPLSGLFAQGMGGAAFMWGSDDMKTMLMGGLELGLRLNLGKGGWYVEPRIRGGYPFIAGAGVAAGWRPKKNEELKAARQEAKAKRQAEIVQRQEAAQEAAQQEAEAKRQAEAQRQEAARQETARQEAARQEAARQEAETKRQTEAQRQETARQEAETKRQAEIVQQTEAQRQEAARQEAQRQETARQEAARQEAQRQETTRQEAARQEAARQIAARQEAARQEAERQQAEAERQVETQRQAEAQRQAEAQRQAEAQRQAEAQRQEAARREAARHVAGVPSEDIAESVALADGRRGFALRITVPFVADLSSLGPGAAGRLREIGETLKGFPDSRVVIQGHTALAGTPGARAQLSRERAEAAADFLIAGEYVRRDQIELQALGAEQPLDSNMTYAGREKNRRVTIIILQGE
>NC_015578.1|WP_148257276.1|2108508_2110230_-|hypothetical-protein
MKTKQIAQWRPKWRQAPFLALVLLGVAGCGNPILRDIWSTEPKPGAQGPLVDPVTDTTAPGLPSGRAIDQASAAGTTATIKFSADEGGTFYYIVLPEADSAPSPQTIQADGASGTAVVGINAILLEGLAAGAGYTVYIVVADAAGNLSAILDIPVSPRHTGANPAKDRSEQNEAALIAAGEITLTAPRAGGGSAQVGITLGEDGRITIVIDGVPREYPYTITGDTIIVAGGGSGGGDAELGFAIGDDGTLTLVGLDKLADGGLAPGAVVSDPNPLLIPPPASILGVAAPSFDGAVYGGERPGAKTITITNSGTADAAISSVALSGDGKDAFVLGGSGDAVSAGGSIATRTVQPAAGLAAGTYAATITVSYDGGAAATAALTVTVVPRPLTATATATDRVYNDTKTVTVTITPTNKVGSDDVTITATGTMADTAPGNDKDVAISNIALTGAAAGNYTAPGSIANTTVTIYPAGKPGITAWVANHAIVTDLPGNTAALSRAGAGGTAKTLPVTVTGGGSGDSYQWSIGGVVQEGETGASYTFDSAGRDTGIYRLTLRVVQGGVPYTTTISITVEE
>NC_015578.1|WP_015708060.1|2105925_2108499_-|GLUG-domain-containing-protein
MSKIVKGFMPVFPAFGALLAALALSCANPASPPPQAPGGTAQVRFAPGFGSSAQASPALRSSPALQAGPGRTVFPSAPAPAGLFPAYTFTKGGESKTPAADGDGVYTLETGDWAVTAKAYLDADHEQLVGESIATPFTVSAEAGVQNIPILLRPIADSGQGAIDYAISYPATATLVALTLAKAGGGTAPDLSPYTDDGAGQRTHGAPNLPAPAGYYDLTVRLVDSLGRTAGKNDVVHVYQNMKTTIPAADWTFTDADFTALLVETAAVTNLVAPVTGKAPAILSSLSVAGGAHYTVTGLTWKLRSGSSPTYTWTDFSGNFVLATYRAAITLKADSGYKFSATPTVNTTSGGTVGDVTLSGDTAENTLTFTVSFPATSGDIAKVEPEWDIPKPQTLAINKSRDTDWISAAGTLTLTLTGSGYSDIQWTVNGSPVAADDPAYIFKGAGRSLGTYTVGVQAKTTDGRWYENWVTITVFVIEAKLVLEGDYLGGITAVVEDGLLKSITPTGKDPILIGRKADEPVTLNLGADGKLQFRTAVSGSIPIGSYGEFQLIRTASGGLSGKYKQEADLDLMGIPPASKGSAWSGQQWTAIGASSSAAQFKGTFDGGGKAISNLFISNTSADDQGLFGYVGQNGTVQNVHIASGSVTGRNRVGGVAGENRGAIIDCSNSGDVTGTNSNNGVGGVVGTGLEFSTITACSNTGNVTGTGTYYSISVGGVVGYLDQGVTVTACYNTGDVICTTPSPNVGGVVGRNWNTNVTACYNIGAVVASGSNVGAVVGNKNSGSTTACYWIERTDVTGSTSSDGGGTKFGEGDAWPSNDASAQWAIGNHDGTSGNYWKSLGGWNSGRPVYPKLWWEK
>NC_015578.1|WP_015708059.1|2102792_2105747_-|peptidase-A26
MINSKKKAGKGAGKFLRNRDEKGAPTLVGRLLFRLGVSAMPKLQLWALGFVLALAGCAVPVSAPVGGPQGAPAGGGLGTVRVEVSGLGPGPGVSAAPKLQADPQGPQRTVYPTPPDTGDLTYTYTWTDITGSGSTVVKVDQDSFGNFILAVGSYTLDVKAYVGDEDDAKLVGTGVGKIDDDTTAIEVGDGDDLTVTVALKPVDGTGAETGTGTLDYTISYPATTTDLTLTLRNLGGETAPALSVGTDTDGTVTYAGTGVTVPAGYYDLTVRLADATGRTAGKNDVVHVYSNMKTTIPPADWTFTDDDFAALLVEAAAVTGLVAPATGEATGEARLPVGAHYGFAATAGFTWQVQTGPGIWADFSDAAFKPRATYRAVITLTAESGYKFSGDITPTVNEGSFPVDWAVSAGTIGGGNTAMNTLRFTVIFPATSGGMAKPDPKWDIPEPHTFAITSDSTTTPLIVKPSKNLTLTLTGSGYGDNIQWTVNGSPVEADASTGRAVYTFKSTGRSLGIYTVGVRAKKNDHWYENRVKVSVTNANLAFLGDYTGGITAVVEGDLLKSITTDAGIILIGRKATDTVTLKLNSSGNLQFRDGVDSSIPIPIGSYAEFQLIRTRVGIGNNYKQEVDLDLMGQEWTPVGDNGNRFEGTFDGDSKTISNLDINKSDSDYQGLFGFVYSGTVKNVRIASGSVTGRENVGGVAGYNQGTITACTNTGSVSGSNYVGGVVGHNYSSSSVTACSNTGPVSGTGENVGGVVGYIEGGSVTACSNIGPVTGRDNVGGVAGVNTYRSVMGTKVAGSVTACYSTGSVTGTGENAGGVVGRNREPLTACYSTGSVSGNKNVGGVAGYNASGTITACYSTGVVKGTTDYVGGVVGYNDVGTITACYSTGSVSGNTYVGGVAGYNYGRAFIIACYWATYTGDGVGGSGGPYDTSGTETGGTTKFGTGWPTIGTNTEWGTGDGSGSGKYWKNLGNSGTLLYPKLYWE
>NC_015578.1|WP_041611111.1|2101845_2102703_-|hypothetical-protein
MMNGKRKAIGVRYLFCGIGFALVGKFLRNLLGVSAVPKLQLWALGFVLALAGCAAPVGGPEGGRLGTVRVEVSGFEVSGPQRTAYPTPPLPSGLTYTYTWMAIEGSPTPVKADRDSSGNFILAAGSYTLDVKAYVGYEDDANLVGTGVGNVSGSTTITVTNDTTVTVTVTLKPVDGRIETSDGTLKYTIKYPAGTTVLSLTLQNFEGGDEVNLTPSAIPSSTLTGTKTGLAAGEYLLRAELKNSANGTAGMSETVHIYGNMTTTVPPTSPAPSAASFVFTAGDFI
>NC_015578.1|WP_169313414.1|2100859_2101591_-|hypothetical-protein
MKVIESNRNHVLSNMHDRKVFCHKGCNLCCHSLSLTVDTLSSYILSKVFEAIPYNELFPFYKKCIDKRIKARAYIDSLPVDTNRNDTLEEYATFGFTVFTCPFVDEQNGCLIYTFSPQICFSYFSSVQCKISYNPVIDENQKLLYEQLGSKAETIDFSGLDNDSKEFHFDDTTFKTYDKFDNLSKTIKQDPNLEYFLSHSMKLEILTIISMALEKTHPGKYKSDMQGIEVDLLAIIDGEMKSL
>NC_015578.1|WP_148257275.1|2100131_2100428_-|hypothetical-protein
MPDYRHLLYAGDSAPAIHTPKQYYCASVLVFPCHHSRVHCCPFVSPVRAQALPPPSLSSYGNYYTLKRYFHRRTTAQQWASQVVATHAIGPGGQLSMF
>NC_015578.1|WP_015708055.1|2099858_2100074_-|hypothetical-protein
MLQLEDDPFFDGFEQGRIEGYEDGVISVYDEFELKFQEIARQFHRCGLDIDQIMSITGLEEEEVEEALEAV
>NC_015578.1|WP_148257445.1|2099450_2099774_-|SARP-family-transcriptional-regulator
MDDNQNLTQAGVNARRSVPAATKAQGKTFTAYKPYTPQFSAAATVTVRRLAWALGCSMPAAVSRLVELLPSLYAAETVCSHCQDKEKCSLCSFKTAAPTPPKDLIYL
>NC_015578.1|WP_015708053.1|2098162_2099140_-|hypothetical-protein
MRNFPQKKPGSGKSLLSRGLSRRFRLGAALAFLALAGILFFALTRPTMTWYVEEELESPWRQVLAAGTPPRGFKGIQSLKPGEAPPAKAKGFLITRKRAELAEPVMVYPRLSFDLEYQGALVLALDPWMVFRNNNFPGLTRQRVESAGEGTLLIPGSDPAAVQAWTARFLERPEGEFPRDGDIWQSTGEALFRRAPFPRGAATFNWPDIWQVLLGKETSWVYAPLSRVRDLPANRSSILEASVFPGPGDNRFGLQAEILWAIPLGKPGKLEKAATWLKSGPAQTLIADTLRWLAASPDAKPFNPVVMSARNAWLTCSYVWECGEW
>NC_015578.1|WP_015708063.1|2112720_2113329_+|hypothetical-protein
MGITPKQERLFSLVPLGDFKALLGIDDREDALARYCLVTASYTIEEYCRRRLLCRKRTEFLHYSGDPVIPLGDYPVRKILAVYKIGRQGEEPILPGLYRTVPECGPEDIPFCLSVDPAAGLERRVVAIRALYLAGYRQGEVPADLASACLELAAWNMSRFRGKRIGMAGAAVRGKAGVGEYLEASMPENVKALLEPYRRRML
>NC_015578.1|WP_015708064.1|2113360_2113807_+|hypothetical-protein
MDYTEDTILRGVKRVLAGAVNELLDEEQDNIPRIEFPGPVDGYLALSRLSGSVCPDISLLGGERTEKDRIIGLEVFDLAITFFVPELDGEQNCYAYAAAVTGALEDDPTLGGVADRAVVVKKKYTPPRTGIFVDGWEAVLTVRVFVEK
>NC_015578.1|WP_015708065.1|2113813_2114665_+|hypothetical-protein
MVNGRDCVIAIGTVPVPYAEETIREAVAALIEQASIEGDGVCRGIQKNCGVTGCIVTPLTIGTAPLLLGLALGEAGIPVFVSETRNLYRRELRLVPYEDGERFELCQERGERGKRFEACGVSGFELRIHQGEAVKLRLDIAGEHGGAPYPSEGGREFATGERFKENGVSYTVNGRELREIYGLTIAAKKIGGTKTEVWIHRVLEESADIPQAIEKLEVTARLYRDRYEQGNQGSGNLGLFRLRLSRLVMMSDETAVDAADAVIGPLRYYCAGDFTAEVFSEGN
>NC_015578.1|WP_015708066.1|2114668_2116156_+|hypothetical-protein
MRFYAIDDSLKEAIDKGTAAVKVRVEIERGGHFEAVFERDIIEASFYGLKEVAGGTSARGEVLLDNPKGMYSAENGAGREVRVSFSIGEGLPWFQRFTFFVDGKGFQDIRGPGRVRRVLLGLRDRSAFLRRTDESRDWTQPAVFTYSVICDKTQPEKSLVHRIAKRAGLAVQDIDCATIPVTLPYVKLTKNTWAELSALATAYRCHLECPVEKPLVFAHSPYQDEPLSADDENPSYTFTGVDIFYLRVTERADQYRNTVRLKINIPVALEKQEIWRYEDPPVLYDSSLAPVYPFRGSALRDIEQYDYEALYTVKDSKGAERRVIFADQIDTIEEAQERLSYEGGPFVYSAYDTTTHHDKAIITLGSDNDGDLFKASIFGRPIVLDVNRSAFLRDSNAVTLHGTCALNVTGSYFSEDVFNGRPQYEDWTAQELAERLQERREITVKTHRALFHGRVGARVKIETRDGTAKGTVNAFSLRYKRDAAFVAAFKVTVTT
>NC_015578.1|WP_015708067.1|2116165_2116393_+|hypothetical-protein
MGEELQRLLVDTIAEMRELKGELREFKKHVMGRVEKLEKKEGERRGDLKATVSVLIAAAALAVSIIVNFFRHGGK
>NC_015578.1|WP_015708068.1|2116392_2116914_+|C40-family-peptidase
MGIKWDKVFENEQRQFEKMTEAEKFIYFLLLQFNSPYGWGKENPELSDCSGAVCLALFAATGHFIRTTADDLYKRVFTAQRPSPDGIKAAFFVDGKTGAASHVAGLVGDGVVLNSQEGGARVRSLDFLSAWFWNRGSSTAIRGLDRAALVRLSHEGSRYDVDPELRRYMEIAL
>NC_015578.1|WP_174269882.1|2116910_2117312_+|hypothetical-protein
MSDSDGIQISDKASWEHSEKELLVILGKRLIALPSKMLGFKPFCLYLATWLLVKGLIRDWIWFAVMVMVLFGIVGLKVIARSGIRNEEGGSRNGGFLAGGGCRGGGGSAGGGDGVCGDSAPGTGPGDYRTMGG
>NC_015578.1|WP_174269888.1|2117350_2117737_+|ABC-transporter-permease
MILMNFLNFPVSGEAPTVMLSDSGSGGMRFYSDTEMTALVAELSEVAEEAIEGAAAEAAKAASLAALDREGAARREAAAALAEARKWEGQYRDEKDGGMKKMVITGVICFLSGLALGAGSILIFGGSL
>NC_015578.1|WP_041611113.1|2117733_2118285_+|hypothetical-protein
MKDRIRVKGMVTVQVLDRDGNIKRRAPSWFGRLFRVPGRPMLYHHHNIVTREGDALIADALLVTPTKTKVSSSAGFIQVGTGWTGNSVKTNVRCNTPTGAMKALDSGYPALKAAWGNTGDTTLVYRASFAAGSLNVNGINEACLLNGNAGGSNCLAYAQITPVVNVTVSDTLQVQWEITILGQ
>NC_015578.1|WP_148257446.1|2118431_2120354_+|hypothetical-protein
MVHLGRKAPSWELNRWGRDALRFSPAVGGSYSLRGDKRTLHYSGDRESHRFTILDGSHFEYDIILNREPEGNRVYLAIEGWEQFDFFRQPDTYGPEILRGSYAVYKKEMVINSPAYHVGTGKICHIHRPKIIDARGRDVWGDVWIDKGLMAITIPEGWLGEAAYPVVVDPMVGSNTVGAYSQFEYLPEWLYWDYLQDLANDPATDMYDYYYDEKTFYDDDIILNRYTTPAAISGTYNTYVYVNKTDNWMRNGQYGIECCASPLLYSEYTNKPKNLLCTNFTIADIRVDSGKPAKWNKATFTVNSIPSGTDVWFGFSCRSIGLQFDYGVPLFRVFNNSIPKDWNYGNKTLTQYLSEYHLLDLSGTIDVFADDDGKNMLPGSRYDMKFSMYLELPPQAYTRTLTQGVKLGDSRKLAAAYKKTLAMNGRNTAALGHGSSYVRKQNETVRGMDLISRIAGICRNLAQQINVGELIGASRGLLRKATDTIKTVTEENRFVGNERSITETGNAADGDINTKRGLFRNMPMTVKGNDDLGRAALLLRVLSGKAAVSDAAGHWGDYVRGLYVAAGSCAGTARQGEYHREAFDTAEVSGMPLRSLGVFIRLVTVGFVRDFLLRRFLKSNEELVLKSAVCRELVLESKIH

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Crispr_ID: NC_015578_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015578_12

2391207-2391302

Orphan

Consensus_repeat	Method
TGCCCTTAAAAGCGTACCGGAAAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015578_12

>merge|NC_015578|12|2391207-2391302|CRISPRCasFinder
TGCCCTTAAAAGCGTACCGGAAAAGTTTAAAACGCCGGAACTCTGCCTTACCGCAGTACAGAATAACAGCTCTGCTCTTAAAAGCGTACCGGAAAA

>NC_015578|12|9|2391207-2391302|CRISPRCasFinder
TGCCCTTAAAAGCGTACCGGAAAA	GTTTAAAACGCCGGAACTCTGCCTTACCGCAGTACAGAATAACAGCTC
TGCTCTTAAAAGCGTACCGGAAAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_015578.1\|WP_015708276.1\|2385489_2385831_+\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	unknown	unknown	gnl\|CDD\|367091
NC_015578.1\|WP_041611142.1\|2385883_2386612_-\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015708285.1\|2394373_2395033_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NC_015578.1\|WP_015708290.1\|2398750_2399452_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_169313422.1\|2389302_2390109_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|381680
NC_015578.1\|WP_041611143.1\|2390101_2390344_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_148257455.1\|2397259_2398123_+\|protein-phosphatase-2C-domain-containing-protein	unknown	unknown	gnl\|CDD\|379325
NC_015578.1\|WP_041611140.1\|2384552_2385032_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015708291.1\|2399455_2401438_+\|ATP-dependent-DNA-ligase	unknown	unknown	gnl\|CDD\|224706
NC_015578.1\|WP_015708275.1\|2384011_2384203_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_148257454.1\|2392145_2393177_+\|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme	unknown	unknown	gnl\|CDD\|335469
NC_015578.1\|WP_015708292.1\|2401559_2402393_-\|formate/nitrite-transporter-family-protein	unknown	unknown	gnl\|CDD\|376497
NC_015578.1\|WP_015708289.1\|2398133_2398739_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015708280.1\|2388500_2389160_+\|tyrosine-protein-phosphatase	unknown	unknown	gnl\|CDD\|350378
NC_015578.1\|WP_015708284.1\|2393166_2394330_+\|formylglycine-generating-enzyme-family-protein	unknown	unknown	gnl\|CDD\|335469
NC_015578.1\|WP_015708278.1\|2386658_2387867_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|226951
NC_015578.1\|WP_015708287.1\|2396379_2397186_+\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|238741
NC_015578.1\|WP_015708279.1\|2387863_2388469_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NC_015578.1\|WP_041611141.1\|2385296_2385503_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015708286.1\|2395046_2396366_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|223589

Protein	Function_ID	Function_description	E-value
NC_015578.1\|WP_015708276.1\|2385489_2385831_+\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	gnl\|CDD\|367091	pfam02452, PemK_toxin, PemK-like, MazF-like toxin of type II toxin-antitoxin system. PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.	6.5787e-19
NC_015578.1\|WP_169313422.1\|2389302_2390109_+\|hypothetical-protein	gnl\|CDD\|381680	cd10030, UDG-F4_TTUDGA_SPO1dp_like, Uracil DNA glycosylase family 4, includes Thermotoga maritima TTUDGA, Bacillus phage SPO1 DNA polymerase, and similar proteins. Uracil DNA glycosylase family 4 includes Thermotoga maritima TTUDGA, a robust uracil DNA glycosylase that shares narrow substrate specificity and high catalytic efficiency with family 1, acting on double-stranded and single-stranded uracil-containing DNA. Members of this family possess four conserved cysteine residues required to coordinate the [4Fe-4S] iron-sulfur cluster. This family also includes the N-terminal domain of Bacillus phage SPO1 DNA polymerase. Bacteriophage SPO1 is one of a group of large, lytic, tailed bacteriophages of Bacillus subtilis, and contains hydroxymethyluracil (hmUra) in place of thymine in their DNA. It has been speculated that this UDG domain may help discriminate between hmUra containing SPO1 DNA and thymine-containing host DNA. Uracil-DNA glycosylases (UDGs) initiate repair of uracils in DNA. Uracil in DNA can arise as a result of mis-incorporation of dUMP residues by DNA polymerase or via deamination of cytosine. Uracil in DNA mispaired with guanine is one of the major pro-mutagenic events, causing G:C->A:T mutations. Thus, UDG is an essential enzyme for maintaining the integrity of genetic information. UDGs have been classified into various families on the basis of their substrate specificity, conserved motifs, and structural similarities. Although these families demonstrate different substrate specificities, often the function of one enzyme can be complemented by the other.	0.00730832
NC_015578.1\|WP_148257455.1\|2397259_2398123_+\|protein-phosphatase-2C-domain-containing-protein	gnl\|CDD\|379325	pfam13672, PP2C_2, Protein phosphatase 2C. Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine/threonine phosphatase.	5.97594e-34
NC_015578.1\|WP_015708285.1\|2394373_2395033_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.71419e-21
NC_015578.1\|WP_015708291.1\|2399455_2401438_+\|ATP-dependent-DNA-ligase	gnl\|CDD\|224706	COG1793, CDC9, ATP-dependent DNA ligase [DNA replication, recombination, and repair].	1.58379e-13
NC_015578.1\|WP_015708292.1\|2401559_2402393_-\|formate/nitrite-transporter-family-protein	gnl\|CDD\|376497	pfam01226, Form_Nir_trans, Formate/nitrite transporter.	4.81796e-85
NC_015578.1\|WP_148257454.1\|2392145_2393177_+\|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme	gnl\|CDD\|335469	pfam03781, FGE-sulfatase, Sulfatase-modifying factor enzyme 1. This domain is found in eukaryotic proteins required for post-translational sulfatase modification (SUMF1). These proteins are associated with the rare disorder multiple sulfatase deficiency (MSD). The protein product of the SUMF1 gene is FGE, formylglycine (FGly),-generating enzyme, which is a sulfatase. Sulfatases are enzymes essential for degradation and remodelling of sulfate esters, and formylglycine (FGly), the key catalytic in the active site, is unique to sulfatases. FGE is localized to the endoplasmic reticulum (ER) and interacts with and modifies the unfolded form of newly synthesized sulfatases. FGE is a single-domain monomer with a surprising paucity of secondary structure that adopts a unique fold which is stabilized by two Ca2+ ions. The effect of all mutations found in MSD patients is explained by the FGE structure, providing a molecular basis for MSD. A redox-active disulfide bond is present in the active site of FGE. An oxidized cysteine residue, possibly cysteine sulfenic acid, has been detected that may allow formulation of a structure-based mechanism for FGly formation from cysteine residues in all sulfatases. In Mycobacteria and Treponema denticola this enzyme functions as an iron(II)-dependent oxidoreductase.	1.00463e-12
NC_015578.1\|WP_015708280.1\|2388500_2389160_+\|tyrosine-protein-phosphatase	gnl\|CDD\|350378	cd14529, TpbA-like, bacterial protein tyrosine and dual-specificity phosphatases related to Pseudomonas aeruginosa TpbA. This subfamily contains bacterial protein tyrosine phosphatases (PTPs) and dual-specificity phosphatases (DUSPs) related to Pseudomonas aeruginosa TpbA, a DUSP that negatively regulates biofilm formation by converting extracellular quorum sensing signals and to Mycobacterium tuberculosis PtpB, a PTP virulence factor that attenuates host immune defenses by interfering with signal transduction pathways in macrophages. PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides, while DUSPs function as protein-serine/threonine phosphatases (EC 3.1.3.16) and PTPs.	5.14238e-12
NC_015578.1\|WP_015708284.1\|2393166_2394330_+\|formylglycine-generating-enzyme-family-protein	gnl\|CDD\|335469	pfam03781, FGE-sulfatase, Sulfatase-modifying factor enzyme 1. This domain is found in eukaryotic proteins required for post-translational sulfatase modification (SUMF1). These proteins are associated with the rare disorder multiple sulfatase deficiency (MSD). The protein product of the SUMF1 gene is FGE, formylglycine (FGly),-generating enzyme, which is a sulfatase. Sulfatases are enzymes essential for degradation and remodelling of sulfate esters, and formylglycine (FGly), the key catalytic in the active site, is unique to sulfatases. FGE is localized to the endoplasmic reticulum (ER) and interacts with and modifies the unfolded form of newly synthesized sulfatases. FGE is a single-domain monomer with a surprising paucity of secondary structure that adopts a unique fold which is stabilized by two Ca2+ ions. The effect of all mutations found in MSD patients is explained by the FGE structure, providing a molecular basis for MSD. A redox-active disulfide bond is present in the active site of FGE. An oxidized cysteine residue, possibly cysteine sulfenic acid, has been detected that may allow formulation of a structure-based mechanism for FGly formation from cysteine residues in all sulfatases. In Mycobacteria and Treponema denticola this enzyme functions as an iron(II)-dependent oxidoreductase.	1.204e-29
NC_015578.1\|WP_015708278.1\|2386658_2387867_+\|ATP-binding-protein	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	3.24004e-35
NC_015578.1\|WP_015708287.1\|2396379_2397186_+\|VWA-domain-containing-protein	gnl\|CDD\|238741	cd01464, vWA_subfamily, VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Members of this subgroup have no assigned function. This subfamily is typified by the presence of a conserved MIDAS motif.	3.19313e-16
NC_015578.1\|WP_015708279.1\|2387863_2388469_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.5219e-41
NC_015578.1\|WP_015708286.1\|2395046_2396366_+\|serine/threonine-protein-kinase	gnl\|CDD\|223589	COG0515, SPS1, Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair].	3.24843e-14

>NC_015578.1|WP_041611143.1|2390101_2390344_+|hypothetical-protein
MPDKPTLKNTGRLCSVYCPQCKRVTDKISFNLLREAGKVSVQCPVCENTTLLEYDGKQAAVWHRSQALDGVIAKVKESKQ
>NC_015578.1|WP_169313422.1|2389302_2390109_+|hypothetical-protein
MPDATQIRDKLKSLYTDLSLMKNDQDLVLYKNCKCKDDCWKGHPVNSKNPENNKITLPYIGKSYIKSGLVCVGLNQHDDGGLDSHYNIIGDKKDGVIKILKDGGKVDKNGSLLWHRTAVYANIILKKIKCKNNNILSVNDEVLEDDKKALSGIFNDIIYMEAIKCSPKVDRSKPFPAMKWQCIPNIFVEELKIIKPKIILLLSKGTSTVLRQCLKNEVAEEEKSKQRHMSRYKMDFNGKTVQVFAVPHPARYNSKDLYSELIDLVTHA
>NC_015578.1|WP_015708280.1|2388500_2389160_+|tyrosine-protein-phosphatase
MKGERARVSTNFHEFRMGSIAPKTLYRSSHPITDADIKDAKAIAKYATKAKIAAVLNLNNTKAELKALAVFAPWYHDLYKADCIIALDMNFDYLSSRFCTKFRRGIQFMLTQSGPYLVHCYAGVDRTGFVCAVLGSLMGAKLREIVADYVASYNDSTMTRNEYKEYSQIIVDLFREMNGGGKISDKNLQSVAEDFLLHKVKLTRKELAGLKMILSINRK
>NC_015578.1|WP_015708279.1|2387863_2388469_+|response-regulator-transcription-factor
MNTLVLIDDHTMMRRGLASYFTQTGRWQVLGEAGSQEEALALFETLSPGPLPGIILLDIDLHGSWGLDLIPRLRNYYEQKPPALIYSVYEDYAHVKAAIRAEAAGYVCKSQGEAELEMAMDAVLQGRIFFAPHLIVKMDAVSDILLCLTKRERQIFGMVQRSYSNRQIAEELVVSVRTIENNLSIIYDKTGVPGRKELEKL
>NC_015578.1|WP_015708278.1|2386658_2387867_+|ATP-binding-protein
MFTLKHPRRLPCKLPAFFLLVFSPTLCAAAVPREQASAGIIPLIEQWMDVERAFYSGDTALPSIFAAFRENMENYMDSPLFRQYAGLPSGDQKETMGSLITAFAEATAAGRQVDAEAAAKGISAALVLWQYFESSVSDAVFARTYFLFALFMLIIGALILALWRIHRDLQHSRIQEQGAAAFSRAVIIAQETERSRISVELHDTVLQDLGRLKQLTEECGGERRGPLLAMEGNIMKTLRSVCQTIMPPDFSRLALADALYSITAEFRERTGIPCRVGISEGLTMEGLTAELQLQCYRLVQEAFTNIEKHAHAETAFLTLQNGRLGDRASLLICVADDGVGMEDTGHPLDYSRMGIRGMYERIGILKGTLSFNGDPGHGLTVRIEIPLGVPSKSSLLLPAEEP
>NC_015578.1|WP_041611142.1|2385883_2386612_-|hypothetical-protein
MKRTILGGVMVTAILCLAGTAGNYGLWRFADFLGQGLYLDTVLTISVTFSGGLAAGLLTAVLSQAAYGIGFYPFWGYYLFAICGAASALVTAFFMRHFPRECSGLRLFSGAPAPARETPLQVEESPLLATKFPAQTSGASFLSVVIMLSILSLFMCILMSVLGGLIAVFIDQALQSPISDAHPETYFKVGLLRQGLSLPAMEILARLPVNIVDRFVSVFGAYGISALLKRAAQLFPVGRRGK
>NC_015578.1|WP_015708276.1|2385489_2385831_+|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin
MKRGEIWTLRDEEYASKARPVIIVQSDPGEFFNSVILCLFTTFESSHIPTRVHIIPDKTNGLQKDSFVMTEKLITIDKKELGEKIGVLTDEQMRQISRGLAKLLEIRKEDISD
>NC_015578.1|WP_041611141.1|2385296_2385503_+|hypothetical-protein
MTIEQTVEIPASRRIYIDLPSQIPIGTARIAINILECPCANEIEAFSDENEATKFTTRLAKRMMHEAW
>NC_015578.1|WP_041611140.1|2384552_2385032_+|hypothetical-protein
MRKKFLAGILFFLISVFVFAEGRSFLLLIFQGRRNIVASNYLVDLSRKQEYLARFKFRISGLLTEWVKLQPSYTGGTITVKEYIGNGADFYYRVYVDNIEYYYVDLSWENSPTITSRIGPFEEILPLVFVDQGKTFLGVDVIRFAIPGQIPIPTDYEEF
>NC_015578.1|WP_015708275.1|2384011_2384203_+|hypothetical-protein
MATQELKDANGRLIGTIRNGSNGGLEIFDESGWLKGTYDPQSDQTKDSSERLVGTGNLLTTLL
>NC_015578.1|WP_148257454.1|2392145_2393177_+|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme
MPCFAYTVIPKNKDKAVADNSFSITLANSINEQGADFLETGAFWDMLEKDANISVSTARLLRFCVETGFHHRVSAAGSSTDILLIARELQKDFFIAPDPAEAILTLLVSLLRPNNPELLPDTGPVYAAGIEDLHRLPPPGNAAPEDAFLFVKGKSFTMGKPGGSGYDHLKPHKVTVGSFYICEFPVRQNEYYQIAQYNPSYRIGAALPVTGVSWYNAVDYCNKRSIIEELQPAYRIDTMPDPQNILAFDAIKWTVSCNAEADGYRLPTDAEWECAYSLFQTDEYTREWCGDLWPVKINSYPQFARTWHKPLNSWDKGSEYPAGNDGPYIGSLSFRLARTAYEQ
>NC_015578.1|WP_015708284.1|2393166_2394330_+|formylglycine-generating-enzyme-family-protein
MSSNIPAIDTFAAILGDLIRDKGAGVLHSPQLKPLLADYTRREYKNEVALFLRIQDSPCAEKIMAASPSDLDGVALALVQFLQDEYALSGSAACLMIGTLSSSLRGVIPASITATPSNLKSWAAAPQLATQFPAHSSVNGGFIQIAPGSFIMGGDLPDVPKHSVAVGAFAIAQHPVTQAEFFTVMGYNPSYSYGADLPVEGLSWYEAVEYCNSRSVYDGLTPVYIIDKTKEAPPLRVLSWGEDPFNWIISADSSADGYRLPSEAEWEYTCRAGTLTDYNTGTRILSLGAACMKSCCPSPVGSFPPNNWGLYDMHGNINEWCSNRTYDGRCYYRGGSYRDNPNSMRSWKRGDPQRPWRTGCPAFIWSADYTDPHGGFIGPYGIRLVKN
>NC_015578.1|WP_015708285.1|2394373_2395033_+|response-regulator-transcription-factor
MEQKDKDEYKRYRDALKRIGQKKTLVLIDSHTMFRELFVSWLIKTGERLWQTYDFSSGSEKLAALFEKKPPDYILLRMDFDMKEALDFLSLIEKQNTKARTVVYSDNTDYTHVRAAYYGSSGGFLSTNETTKDILHCFSAVEYGNKYIDVHNAQKMADAAEKVKSLLKKEQEVFTLVQQGFSNAEMAAQLGIGKHSVENYLSALYTKFGVENRKNLETL
>NC_015578.1|WP_015708286.1|2395046_2396366_+|serine/threonine-protein-kinase
MKKSGINEKEYPSGKTLKTCALKTVKVGEKLGEGGQGAVYRVSYDGKPKALKWYFSGRISSPKKFYENLENNIKKGAPNAAFLWPLDITEPGAGAVNSGTFGYIMDLRPEGYKDFSRFLLAKEKFASLTALTNTALQIVEAFRELHNSGYSYQDLNDGNFFVNPKTGDVLICDNDNVAEYGKNLGIAGKCRYIAPEIVLGKALPSVHTDKFSLAVVLFLLLMYNHPLEGKKAFPPCMTEALERKIYGEEPVFIFDSEDDSNAPLPEINNNAIKRWPLYPAYIREKFCEAFSKKALGDPSFRVIEKDWLKVFIRLRSEIYKCDICGNVFFADPVKSTYCPDCRTEHLFQRHIELPKWDIAVHKRTRLYACHTELDSDDFKTLTAEITVNESGGFELKNLSKKTWLVIDAKGKQVSRGMNKTVPMEKGTQIVFGNVTAAIL
>NC_015578.1|WP_015708287.1|2396379_2397186_+|VWA-domain-containing-protein
MGLNDAVEAIPRKTMVLFFLIDTSGSMSGSKIGAVNAAIEEVLPELRDLSASNADAEVKIAALEFNNTALWITKDNPVKVDDFRWTYLDAAGSTYLGDACLQLNDKLSTKSFMREASGSFAPAIFLLSDGEPTDNFDGGLAELQKNNWFKAAIKVAVAIGDDANKLELAKFTGSMESVLEVHNAVMLRKMIRFVSVRSSQVASKSVQIKTPAATPMPTAAQTAASNVPSAPVSPAPQAPAETGAKQQDLNEQLKEIAAEAANAGDEEW
>NC_015578.1|WP_148257455.1|2397259_2398123_+|protein-phosphatase-2C-domain-containing-protein
MMYQAFSCSVIGASHAKSGKPCQDYSLHYADKNVVIAVVADGHGSAAHFRSDRGARIACECAVKFIAAFAEKYGGNLGESELPELARNIASEWDKRVAGDWEKDPPVGLSEEQAAGDSEEPEKSKNPKDILNPRDPPDSRNPREAYGSTLIAAGVSRSGWFGLQIGDGKCAVRYADGDFLQPIPWDEKCFLNVTTSLCDTDPGSEFRYYASRKIPAALFIGTDGVDNSYPVHENEKHLNGLYSIIEDNFSKEGFKKGLMELCDFLPVLTQKGSGDDVSIAGIVRVNP
>NC_015578.1|WP_015708289.1|2398133_2398739_+|hypothetical-protein
MARGLTFLIQGISYSAAPEKIDRKKLYGRQETQAIARDDSVCSLVSMDESSGLILPKGGIGMGNLSSMGEWVERSTLKTVALDGSELGLHKSSYDGSITIEQAVTPEVFLNHTIKTIYKLPVPPECIAAVGKSIYTFPYNYRDSYEQETAFLLVSNNTLFMLTGYEASFAMLTLEQNAMLGDMETEDIDEESDSEIDFSFR
>NC_015578.1|WP_015708290.1|2398750_2399452_+|hypothetical-protein
MRLINITNEKQRDAKVALEPFPYRQRTKLVMADGTEKQSVQFIKTTTSFEALISQHGSLDAVGEALISGDREIDFEQVGRFLHKTVKLYVHTNGDMAYMFNLVQTLFNKEGEEIERRNLSKQAANIASEIPIRWTGKQIPKDEAIRRFVFTRNYQLRHTSGLSYDFLFDMARQLHTQNTLLLVGGGKSGAEPIVLSLGGTPYRGFLEGRIEGEPAGTAYCLILHLSNMELKDI
>NC_015578.1|WP_015708291.1|2399455_2401438_+|ATP-dependent-DNA-ligase
MSLLNLAEALPRKSTVIFLIIDTCMPDLKRNTLETAITQLQSCLQDLSETSSETCLETDLLYYEGERGFSAMCDTLGGKLSTKTFLKNPQGYYPPVIVLFSAGSSDSGNFAETESALVKLHANNWWKAADISAVAIGKACNRDFLGHWASNAELVLDANTPSCLERIVKSINAPRFSRVYNSVEDLTPPEMDKDRQVPSEYSQQAVDYKKNISKNFVPLNPSQIEDRLYGNEFFVTRKYDGLLTLLFWENNGGTGDGKLTIVNSSGKTLDSSLPCAAAAASCFSRSKIQSAIIAAELYADESGGRTRVTDALSALAEKGDHNHLRLAPFDIVSLDDVQWQGENYGQTHVQLGYIFTDTQFVYPVRHTVCHNKFEVQSIFTEWVEGEGSEGLVVRSGKTGLYKIKPRQTIDAAVVGFSEADGGGAVRSLLYALMKKEDGEADQYQIIGRTGNGLTTEQKKSLYSRLMAQKIPSNYVEVDSNHAAFHLVKPELVVELSVNDVLTENAAGLIRNPLLALQKSGLNKIGAAPGYSFVSAVIERFRDDKKVNPVDLRLSQIPVQTALSPTVMSLPTETAPSKVLFRRVYKKESSSMMVQKYVVWRTNKGGTPDYPSFVFSYTNFSAGRAEPLSIEVRISESEEQIMALCRRCIEKEVKTGWMQIG
>NC_015578.1|WP_015708292.1|2401559_2402393_-|formate/nitrite-transporter-family-protein
MEARSPAEILAYTSDAGVTKVRRNLFQELILAFLAGVFIAFASEGSNMAAFNLFADPNTYGLGKVLAGAVFGTGLMLVVLAGGELFTGNTLIAVAALDRKIKVRELLCNWLVVYIGNLIGSLFIAYMMKESGLFNSGANVLGGQTIKIAAYKTALPFHSAFFLGIMCNWLVCLAVWVSYGSKDLTGKILAIFFIICLFITSGFEHSVANMYYIPAGIWAKANPAWVEASHVAADALANLNWGTFFYKNLLPVTLGNIVGGAGMVGLLYWLSLKKKAA

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Crispr_ID: NC_015578_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015578_13

3225033-3225502

TypeIII

Consensus_repeat	Method
GTCGCAATCCCTTTTAATTCAGGTCATTGGTTAAAAT	CRT
GTCGCAATCCCTTTTAATTCAGGTCATTGGTTAAAAT	PILER-CR
GTCGCAATCCCTTTTAATTCAGGTCATTGGTTAAAAT	CRISPRCasFinder

6 spacers

cas6,cas10,csm2gr11,csm3gr7,csm4gr5,csm5gr7,csx1

The CRISPR arrays of NC_015578_13

>merge|NC_015578|13|3225033-3225502|CRT,PILER-CR,CRISPRCasFinder
GGCAGTTTAATCCCTTAAACAGGTCAGTGGTTAAAATACGGGAAACTCAAATTGTATATTACCGTGTAAACAGTCGCAATCCCTTTTAATTCAGGTCATTGGTTAAAATCACAAAAACTAGACAAGCGTGTCAGATTGCACAAGTCGCAATCCCTTTTAATTCAGGTCATTGGTTAAAATTGAAGGCACCGTTGAACATAACAACGTGGGGTTCAAGTCGCAATCCCTTTTAATTCAGGTCATTGGTTAAAATAAGTATAACCATTCAACGTTGACGGATATCATGAAGTCGCAATCCCTTTTAATTCAGGTCATTGGTTAAAATCCATAAAAATGTAAAATATATATTATCACGTAAACGTCGCAATCCCTTTTAATTCAGGTCATTGGTTAAAATTGGCCGAAAAATTACCAGTAAAAAAGGCTTACTTAAGTCGCAATCCCTTTTAATTCAGGTCATTGGTTAAAAT

>NC_015578|13|1|3225033-3225502|CRT
GGCAGTTTAATCCCTTAAACAGGTCAGTGGTTAAAAT	ACGGGAAACTCAAATTGTATATTACCGTGTAAACA
GTCGCAATCCCTTTTAATTCAGGTCATTGGTTAAAAT	CACAAAAACTAGACAAGCGTGTCAGATTGCACAA
GTCGCAATCCCTTTTAATTCAGGTCATTGGTTAAAAT	TGAAGGCACCGTTGAACATAACAACGTGGGGTTCAA
GTCGCAATCCCTTTTAATTCAGGTCATTGGTTAAAAT	AAGTATAACCATTCAACGTTGACGGATATCATGAA
GTCGCAATCCCTTTTAATTCAGGTCATTGGTTAAAAT	CCATAAAAATGTAAAATATATATTATCACGTAAAC
GTCGCAATCCCTTTTAATTCAGGTCATTGGTTAAAAT	TGGCCGAAAAATTACCAGTAAAAAAGGCTTACTTAA
GTCGCAATCCCTTTTAATTCAGGTCATTGGTTAAAAT

>NC_015578|13|4|3225105-3225502|PILER-CR
GTCGCAATCCCTTTTAATTCAGGTCATTGGTTAAAAT	CACAAAAACTAGACAAGCGTGTCAGATTGCACAA
GTCGCAATCCCTTTTAATTCAGGTCATTGGTTAAAAT	TGAAGGCACCGTTGAACATAACAACGTGGGGTTCAA
GTCGCAATCCCTTTTAATTCAGGTCATTGGTTAAAAT	AAGTATAACCATTCAACGTTGACGGATATCATGAA
GTCGCAATCCCTTTTAATTCAGGTCATTGGTTAAAAT	CCATAAAAATGTAAAATATATATTATCACGTAAAC
GTCGCAATCCCTTTTAATTCAGGTCATTGGTTAAAAT	TGGCCGAAAAATTACCAGTAAAAAAGGCTTACTTAA
GTCGCAATCCCTTTTAATTCAGGTCATTGGTTAAAAT

>NC_015578|13|10|3225105-3225502|CRISPRCasFinder
GTCGCAATCCCTTTTAATTCAGGTCATTGGTTAAAAT	CACAAAAACTAGACAAGCGTGTCAGATTGCACAA
GTCGCAATCCCTTTTAATTCAGGTCATTGGTTAAAAT	TGAAGGCACCGTTGAACATAACAACGTGGGGTTCAA
GTCGCAATCCCTTTTAATTCAGGTCATTGGTTAAAAT	AAGTATAACCATTCAACGTTGACGGATATCATGAA
GTCGCAATCCCTTTTAATTCAGGTCATTGGTTAAAAT	CCATAAAAATGTAAAATATATATTATCACGTAAAC
GTCGCAATCCCTTTTAATTCAGGTCATTGGTTAAAAT	TGGCCGAAAAATTACCAGTAAAAAAGGCTTACTTAA
GTCGCAATCCCTTTTAATTCAGGTCATTGGTTAAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_015578.1\|WP_015708985.1\|3230676_3231675_+\|class-II-fructose-1,6-bisphosphate-aldolase	unknown	unknown	gnl\|CDD\|180829
NC_015578.1\|WP_015708982.1\|3227979_3228702_-\|flagellar-filament-protein-FlaA	unknown	unknown	gnl\|CDD\|309664
NC_015578.1\|WP_148257320.1\|3223986_3224910_-\|CRISPR-system-precrRNA-processing-endoribonuclease-RAMP-protein-Cas6	cas6	mkCas0066_cas6_CAS-I:CAS-III	gnl\|CDD\|337605
NC_015578.1\|WP_015708987.1\|3234116_3234803_+\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015708973.1\|3217181_3218513_-\|TIGR02221-family-CRISPR-associated-protein	csx1	cd09732_csx1_CAS-III	gnl\|CDD\|378186
NC_015578.1\|WP_015708976.1\|3220574_3221249_-\|type-III-A-CRISPR-associated-RAMP-protein-Csm3	csm3gr7	cd09684_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|187815
NC_015578.1\|WP_015708970.1\|3214450_3216496_+\|excinuclease-ABC-subunit-C	unknown	unknown	gnl\|CDD\|234792
NC_015578.1\|WP_041611215.1\|3234943_3236032_+\|phosphatase-PAP2-family-protein	unknown	unknown	gnl\|CDD\|239486
NC_015578.1\|WP_148257318.1\|3212664_3214341_-\|fibronectin-type-III-domain-containing-protein	unknown	unknown	gnl\|CDD\|214495
NC_015578.1\|WP_015708986.1\|3231798_3234069_+\|lipoprotein	unknown	unknown	gnl\|CDD\|223039
NC_015578.1\|WP_015708975.1\|3219686_3220565_-\|hypothetical-protein	csm4gr5	mkCas0089_csm4gr5_CAS-III-A:CAS-III-D	unknown
NC_015578.1\|WP_015708974.1\|3218509_3219670_-\|hypothetical-protein	csm5gr7	mkCas0182_csm5gr7_CAS-III-A	gnl\|CDD\|273863
NC_015578.1\|WP_015708984.1\|3229588_3230515_-\|hypothetical-protein	unknown	unknown	unknown
NC_015578.1\|WP_015708978.1\|3221775_3223977_-\|type-III-A-CRISPR-associated-protein-Cas10/Csm1	cas10	cd09680_cas10_CAS-III	gnl\|CDD\|187811
NC_015578.1\|WP_015708977.1\|3221278_3221770_-\|type-III-A-CRISPR-associated-protein-Csm2	csm2gr11	pfam03750_csm2gr11_CAS-III-A	gnl\|CDD\|367635
NC_015578.1\|WP_015708981.1\|3227267_3227846_-\|Uma2-family-endonuclease	unknown	unknown	gnl\|CDD\|99749
NC_015578.1\|WP_015708980.1\|3226011_3227220_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380413
NC_015578.1\|WP_081468672.1\|3225859_3226027_+\|BrnT-family-toxin	unknown	unknown	gnl\|CDD\|367913
NC_015578.1\|WP_015708983.1\|3228714_3229446_-\|membrane-protein	unknown	unknown	gnl\|CDD\|309664
NC_015578.1\|WP_015708968.1\|3211102_3212668_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|274350

Protein	Function_ID	Function_description	E-value
NC_015578.1\|WP_015708985.1\|3230676_3231675_+\|class-II-fructose-1,6-bisphosphate-aldolase	gnl\|CDD\|180829	PRK07084, PRK07084, class II fructose-1,6-bisphosphate aldolase.	0
NC_015578.1\|WP_015708982.1\|3227979_3228702_-\|flagellar-filament-protein-FlaA	gnl\|CDD\|309664	pfam04620, FlaA, Flagellar filament outer layer protein Flaa. Periplasmic flagella are the organelles of spirochete mobility, and are structurally different from the flagella of other motile bacteria. They reside inside the cell within the periplasmic space, and confer mobility in viscous gel-like media such connective tissue. The flagella are composed of an outer sheath of FlaA proteins and a core filament of FlaB proteins. Each species usually has several FlaA protein species.	2.5199e-52
NC_015578.1\|WP_148257320.1\|3223986_3224910_-\|CRISPR-system-precrRNA-processing-endoribonuclease-RAMP-protein-Cas6	gnl\|CDD\|337605	pfam10040, CRISPR_Cas6, CRISPR-associated endoribonuclease Cas6. Cas6 is a member of the RAMP (repeat-associated mysterious protein) superfamily. It is among the most widely distributed Cas proteins and is found in both bacteria and archaea. Cas6 functions in the generation of CRISPR-derived guide RNAs for invader defense in prokaryotes.	0.00200464
NC_015578.1\|WP_015708973.1\|3217181_3218513_-\|TIGR02221-family-CRISPR-associated-protein	gnl\|CDD\|378186	pfam09455, Cas_DxTHG, CRISPR-associated (Cas) DxTHG family. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. The family describes Cas proteins of about 400 residues that include the motif [VIL]-D-x-[ST]-H-[GS]. The CRISPR and associated proteins are thought to be involved in the evolution of host resistance. The exact molecular function of this family is currently unknown.	4.88076e-29
NC_015578.1\|WP_015708976.1\|3220574_3221249_-\|type-III-A-CRISPR-associated-RAMP-protein-Csm3	gnl\|CDD\|187815	cd09684, Csm3_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein.	2.74765e-82
NC_015578.1\|WP_015708970.1\|3214450_3216496_+\|excinuclease-ABC-subunit-C	gnl\|CDD\|234792	PRK00558, uvrC, excinuclease ABC subunit UvrC.	0
NC_015578.1\|WP_041611215.1\|3234943_3236032_+\|phosphatase-PAP2-family-protein	gnl\|CDD\|239486	cd03392, PAP2_like_2, PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.	9.48718e-25
NC_015578.1\|WP_148257318.1\|3212664_3214341_-\|fibronectin-type-III-domain-containing-protein	gnl\|CDD\|214495	smart00060, FN3, Fibronectin type 3 domain. One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.	2.11038e-09
NC_015578.1\|WP_015708986.1\|3231798_3234069_+\|lipoprotein	gnl\|CDD\|223039	PHA03307, PHA03307, transcriptional regulator ICP4; Provisional.	0.000434544
NC_015578.1\|WP_015708974.1\|3218509_3219670_-\|hypothetical-protein	gnl\|CDD\|273863	TIGR01899, cas_TM1807_csm5, CRISPR type III-A/MTUBE-associated RAMP protein Csm5. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. Members of this cas gene family are found in the mtube subtype of CRISPR/cas locus and designated Csm5, for CRISPR/cas Subtype Mtube, protein 5.	6.98999e-07
NC_015578.1\|WP_015708980.1\|3226011_3227220_+\|hypothetical-protein	gnl\|CDD\|380413	cd07010, cupin_PMI_type_I_N_bac, Phosphomannose isomerase in bacteria and archaea, N-terminal cupin domain. This subfamily contains type I phosphomannose isomerase (PMI; E.C. 5.3.1.8; also known as mannose-6-phosphate isomerase) found in many bacteria (e.g. Bacillus subtilis) and archaea. PMI catalyzes the reversible isomerization of fructose-6-phosphate (F6P) and mannose-6-phosphate (M6P), the first committed step in the synthesis of mannosylated glycoproteins. The active site, located within the N-terminal jelly roll-like beta-barrel cupin fold, contains a single essential zinc atom and forms a deep, open cavity large enough to contain M6P or F6P. PMI type I also has a C-terminal beta-barrel fold which has diverged considerably from the N-terminal domain and is not included here. This subfamily does not contain an alpha helical domain that exists in eukaryotic and some prokaryotic PMIs. F6P is a substrate for glycolysis and gluconeogenesis, while M6P is a substrate for production of activated mannose donor guanosine 5'-diphosphate D-mannose, an important precursor of mannosylated biomolecules such as glycoproteins, bacterial exopolysaccharides and fungal cell wall components. PMI is also essential for survival, virulence and possibly pathogenicity of some bacteria and protozoan parasites, as well as for cell wall integrity of certain yeasts. Thus, PMI is a potential target against fungal infections causing serious illness or death.	0.00050623
NC_015578.1\|WP_015708977.1\|3221278_3221770_-\|type-III-A-CRISPR-associated-protein-Csm2	gnl\|CDD\|367635	pfam03750, Csm2_III-A, Csm2 Type III-A. Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-associated) proteins. This entry represents Csm2 Type III-A, a family of Cas proteins also known as TM1810/Csm2.	3.14086e-10
NC_015578.1\|WP_015708981.1\|3227267_3227846_-\|Uma2-family-endonuclease	gnl\|CDD\|99749	cd06260, DUF820, Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of nucleases.	6.48741e-48
NC_015578.1\|WP_015708978.1\|3221775_3223977_-\|type-III-A-CRISPR-associated-protein-Cas10/Csm1	gnl\|CDD\|187811	cd09680, Cas10_III, CRISPR/Cas system-associated protein Cas10. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Multidomain protein with permuted HD nuclease domain, palm domain and Zn-ribbon; signature gene for type III; also known as Csm1 family.	2.21043e-87
NC_015578.1\|WP_081468672.1\|3225859_3226027_+\|BrnT-family-toxin	gnl\|CDD\|367913	pfam04365, BrnT_toxin, Ribonuclease toxin, BrnT, of type II toxin-antitoxin system. BrnT is a ribonuclease toxin of a type II toxin-antitoxin system that exhibits a RelE-like fold. The antitoxin that neutralizes this toxin is pfam14384. BrnT is found in bacteria, archaea, bacteriophage, and plasmids. BrnT-BrnA forms a 2:2 tetrameric complex and autoregulates its own expression, which is induced by a number of different environmental stresses. Expression of BrnT alone results in cessation of bacterial growth which can be rescued after subsequent expression of BrnA.	9.50371e-08
NC_015578.1\|WP_015708983.1\|3228714_3229446_-\|membrane-protein	gnl\|CDD\|309664	pfam04620, FlaA, Flagellar filament outer layer protein Flaa. Periplasmic flagella are the organelles of spirochete mobility, and are structurally different from the flagella of other motile bacteria. They reside inside the cell within the periplasmic space, and confer mobility in viscous gel-like media such connective tissue. The flagella are composed of an outer sheath of FlaA proteins and a core filament of FlaB proteins. Each species usually has several FlaA protein species.	1.08691e-24
NC_015578.1\|WP_015708968.1\|3211102_3212668_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	3.24346e-18

>NC_015578.1|WP_148257320.1|3223986_3224910_-|CRISPR-system-precrRNA-processing-endoribonuclease-RAMP-protein-Cas6
MKLFYKKIRFTLAFAGELRFPVPPAFVFRSIIGAQLHRICCIAHGVKCPDCMFSGTCAYGFAFESILPRDNPVLSGRDRISHPVIIETESFLEKPGDSLGLYLIFLGPAIKYLPYFFYALKKGGEAGILRERVPFRVTGVFDDGHELLEDEETLNTRFEPDVWEYVPGDGAVKQRRLMVQMLSPLRFKVQGHYDDSFSAADFALCLHRRTRTLCSQYGVVHDNDVEGGYYFSEAWAIKERNLVWRDFAHYSARQRKTMQFGGLTGSMVLEGAFSAYEYACLGFAEIFHAGKNTNFGLGRVTVWAKEG
>NC_015578.1|WP_015708978.1|3221775_3223977_-|type-III-A-CRISPR-associated-protein-Cas10/Csm1
MDDIHASYNEVVLAAWLHGVDGLYGDGFLQSLKPYFPADVRPDEVIRLASAYRNPSGYDEGIIAHACGLGCGVPGKTERAPSPFEKPLVHMVSALNIDNRKSVHSYYVPGPMDGSISFSAENQKTGKEPYREIMRGFEKDFQALSGKGWVEFMPALDTLFEHYLWCVPSGTDPLVSFYQYSKSTAAFAGALYRYHQAAGTESLEALSSGKEAGFLFINGDMSGIQRYIFDLKDTKQSAKMLRARSFQVWALSEVIAEYLALCFKGSRESIISSAGGKFLLMVANTQENRNAIPGLRLELERYFAGEFAGKLMFILSDGVSAGDDDLGKGLVQDLLNRIGTDAEWAKQRKMQTFLDAEGPVLESFYSSLLENGECACCGVLPGKLPYGDGGDKKICPNCSDLIALGGKLLRANRVVLKTEKLLPLGSMIAIQQKNESPSGYTINEYKAGSPLMFLPYVAPWMDEKRGILKTFEDIAGCSKGSNKLAMFKADIDNLGLVFSSSLGDRVSFAAYAALSRQLHYFFSAYYARFVNGHPEYSEKIYTVFSGGDDLCVLGAWDAVMRFAGDFRKELEKFTNRNPSVTLSGGIAMANPALPVRNIAEEADAALEMAKGRQTNGGIVKNGICVFGVTVSWEEYDKLLDEGEKFFKYLNEGKLSAGLVYKMIDFANRAKNFRIKGNLRDMVWASNFRYMAARNIPDEKLRNWFLKFGTTENIEKSRIAVSYALYARRHAKEE
>NC_015578.1|WP_015708977.1|3221278_3221770_-|type-III-A-CRISPR-associated-protein-Csm2
MDRNGGYRGNQDRGGQRNDLPPSPPPVKIDSFYADGKLLVDLFDETAEKIADSFLVKNTRTAVSKTQLRRLFDEVKRFEQIIDVSPEQFSSQLPYIRMIRSKVTYLTARAIKDNFAAKVVYQNLSAFISDCIKLIKEAKDYHVFVSLFEAVYGFYWEKNHNKD
>NC_015578.1|WP_015708976.1|3220574_3221249_-|type-III-A-CRISPR-associated-RAMP-protein-Csm3
MKQIGNKKITGTIVVKTGLHVGAGTDKVEIGGMDNPIIRNPLNREPYIPGSSLKGKMRSLLEWKFDLVEKNAGRVCSCGEPDCKICRVFGAGNTAKTSESAKKRGPSRLIVRDAALTEDWSRQFKEGKTLVEEKSENSLNRITAEANPRPIERVVPGVEFSFEMIYRILDTGDGGKTDGEYFDLVVLEGLRLLQNDYLGGGGTRGNGRIGFKDLKDESNKEIKL
>NC_015578.1|WP_015708975.1|3219686_3220565_-|hypothetical-protein
MTLYRITLRLCSPLATPLKGDTIWGHIAWGIANHEGDEGIGEFLSREKSGDPSLVVSSAFPTGMLCRPIPEPQERTKSGLSAEEYAKIKLNKKLKYLAAADYVSGVAEMSGDEAGSFKAVPVLHNTIDRSSNAVLEGGLYMVQEEWAGTADWDIYVLSSDPAERVQELCEWAFENGYGADASTGKGKILVKNSPEPVEARKTGSVYMALGPFVKESNTIITDLRGDIFIRSGRLGGDFASIVVPYKKTVLLYDAGAVFTSEKRLGYVGKILPNVHMDPRICQSAFTPVIPIA
>NC_015578.1|WP_015708974.1|3218509_3219670_-|hypothetical-protein
MAKKTYSLVVTPLTGVHIGTGEKLNPLDYKLVKSSSGAANAKVVKDMYWKFSSDHILRRLIAGGANLTDFERASVDGNMGELRHFFHENCTVEDIDYLCDITEEFKRQYSRNLQNDPGENAAEVHQMYHPGGSKKPVIPGSSIKGSIRTGILNFRLASLEDNEYNALPHEKKDAALQKKLLRYSDEKSDPFRCISLEDCAFQAKDTQLVGVLKNIRYNRHHQTLDGLEKLQIQAEVIRGKFLGGVYSAETAISIDADLQDVQFPESAQRRGSPANITPISMQDLMEACNYFYLREFKKEYEHFYSESIEGTDLIVKLKQDLEEAVQGKNQFIIRVGRWSQVEFVTFEEEFRIPYNTKGSGGTRTVFDYNGQYVPMGWCSITAKENV
>NC_015578.1|WP_015708973.1|3217181_3218513_-|TIGR02221-family-CRISPR-associated-protein
MKHYTLISFVGTGAFKKDGGKEGYSEASYQFPNGTTYTTNIFLEALLKSGYRSIKKVILLGTRTSSWDVLLADIRSDSSSPDYGSLWSKIIDECESAGISDESAALLEEALSKKLCLPVAIKVHTPVIDAETIPEIFPIYNTLVSELAPETDILLDITHSFRSLPILVYQALQFGLTGLPPRNVELIYGEIRNNGLSPARDLSQYWQLSQITEAKNLFARRLDGKRLAQLLHDEWPQGEELISRFSTIVECNLALDIPKWLKDANRDLGRPLKGTEPEWVLEIRKIVQSEIVEKISPAKGNRSLKTSEVLRSFSALLEQHGLFIQAIITLQVALETRTIEAFGSPDDIGDYSAWHDIDGPNYQKNYQQKREALNVVHPLRDIESIRNAIAHGGYKKRWGSKASKGLSFTAQEIRDALKKSKEAVQIFFDNVRPKDSVVEGQVP
>NC_015578.1|WP_015708970.1|3214450_3216496_+|excinuclease-ABC-subunit-C
MPSAANTVFDTLKAAAHDAPQEPGVYIMRDEESRIIYVGKARVLRNRLSSYFSGAKDIKTHTLIHNARSIETIIVANEYEALLLENTLIKQHSPRYNINLKDGKTYPVIRVSADPFPRVFRTRHIIEDGSRYYGPFPNVQAVDTMLELVDKLFPLRKCRSLKKRKAPCMYFHIGRCAAPCCGKITEGDYHLHVDRVQKLLAGETGSLIIDLTEQMHGAAKQLFFERAAQIRNTIDAIGNLSEGPTVVDFDPEGRDYIAWASESLLTTWSVFSMRGGKMTGRELFRTRSAADETESLETFLASYYSPDRPPPSRIFIRGEGVNAPPLEQTASAPEQAAPSEPATAQSVTFNEVSRTLLLSWFREQFGCEPELLFPEEKRHQAVLAMARQNALEDLRQQLKERGAGPALDELRQALNLRSRPERIEGFDIAQLDGKHPVASLISFKNGIPDKKNYRYFKLRSVVGVVDDFAAMREAVHRRYSRLIKEGTELPDLILIDGGIGQVNAAKGVLKELGADPDLVGLAKRDEELWLPAAREPIRLSKRSEALKLLQHVRDETHRFATGLNQKLRSKDLLFPTLESVEGIGPKRAAAIMKAYGNLPAIAAADPADLAETCGLSEAAARAVHAAALLALQDQAAAKARLTKGVHSRSRAATAAGQAAYPADEAISFLAAEAAEDEFGGE
>NC_015578.1|WP_148257318.1|3212664_3214341_-|fibronectin-type-III-domain-containing-protein
MRKATVLTLITGIFLQITAGLYGVGESTLILGAGSSWNAVVNRSGIAEVSAIRPNPVLTLSSVRPGNDPYLDMALSFDEDRPESFTDLTGHYQVSVSAALSAVNYRWSRAGTGAALFSGDSPLGAQDQSLPFARDSTGASRGFSDLSEGPLVITPRGQNALLSSGRHFRDFSIEFWLYPLNMENGEQIISWTSTRQTAQGAKTFQRILCGAAKNRLSWTFLDFFSSPDDSRQMTLSLSGSPVLPRVWSHHLIRFDSDTGLLEYLVDGRLEGVVYATSSGREGGELFCPVSGDGGTLVLGKRFAGLMDEFRLYGRYNEAPQLSKYSLQGGRIETRPLDLGERNSRVLKIETLGGNFSPGGKNPRAAAIMQNEYAGSGRFRFANDSMVQFFIRAADSPYQWAAADTGWIPFEPGLEFSENMRGRYIQLAAAFYPSGDGEAAPYLDEIRILYQRDDPPLPPSLVTAIADDGAVELSWKASPDQDLSGYLVYFGTAHGEYFGESAILGVSPINVGKRTSFRIEGLKNGTLYYFTVAAYDRNSTANAGMFSREVSARPLRMVE
>NC_015578.1|WP_015708968.1|3211102_3212668_-|tetratricopeptide-repeat-protein
MSTQDVQDLTKRARMFIRDGRYKEATETLNTALETDPEFIAAHNLRGIAYGKLREWKKSLAAFRKGLTLDRNSPTLHLNYGIALEARGQPQRAPSHYRSAIRNNPEWIDALNALGIVQFKQEVYNSANRTFSRVLKVDPDNAEALNNKGVVLADQGRHKEAIKKYRAALEKDSRYIKAALNLARALEDTGNFPGALEELERLADMAPTDWDVRTRLAGLYQKLERYDDAMDQASAVLEKDPENIQAMRIAGSVQGIQGNDEEAKNIFEKITTLDPAAETGDTYTKFMLEDPESRYCLDLIPATPAPPKPAPGKRGSGKAAKASASKSPAAKAGSAEPVSKTVPVEPSPPAAEIEAVAEVEPVAETETVEEVEAAAEAELVIEVEPAVEAETIAEIEAVEEVEAVAEAEIVAETETAAEVEAVAEIEPVEEVEAAAGAEIVAETEAVAEIEPIEEVEPVEENETAAVSLSFAGSPEPDLLGLMRYLMVLTESLPESALNEFMHSDAHMELKFIIDTLENPNG
>NC_015578.1|WP_081468672.1|3225859_3226027_+|BrnT-family-toxin
MYGKILFTVYTERGENKRIISARLADKAIHNIDIDKSPTPYLYYPHTGGPSWTKL
>NC_015578.1|WP_015708980.1|3226011_3227220_+|hypothetical-protein
MDKALIEKTLQRGEGIFRLNPAFIPRPFGKAGHRLRLHPDDYYAYGLERGSIKERWMTSTNVAQNGPLAGPEEGLSFVAVDFGSDEKFSLKEAIQVLGADLVGEELMKKYGGWPVFSKFYDLTTPLFHHLHLGFEDAARVGKLGKPECYYFPRQFASHSGEMDATYFGYDPDTKPEQVKQRLLDYNKGDNRITELSRAYRIELGSGWYSPPGVIHAPGSVLTFELNWNGDVNSVHENVVSGEIFPRNFLNGECPEDKKDDIEYIFSLLDWEKNIDPHYKKHFGRPPIVISSNADYEEKWVSYANDGYFSAKELTIFPGKTVTLKEPVVHGIILTQGHGKLGPHICESPTMLRFGQQSADEFYVSEPAAKKGVVISNQSPVEPLVLIKSFGPNHPEAPKSVGN
>NC_015578.1|WP_015708981.1|3227267_3227846_-|Uma2-family-endonuclease
MSGPVSVEAEKTHYTYADYLEWETDKRYELMDGEAYMMASPSVIHQRISMSLTVQFGSFLLGKPCEVFAAPLDVRLFPREDHSDDTVLQPDLFVVCDKTKLSKGSCDGAPDLVIEIVSPSNTVKEILKKFNYYLDAGVREYWIVDPDNKTVQVHILKDGHYVSGIYKTGAIPVSILPGLEIAITSFWEENPA
>NC_015578.1|WP_015708982.1|3227979_3228702_-|flagellar-filament-protein-FlaA
MKRYIIIALLISIGGLAFAQQEEVGGTNTERLGIDAAQQKLKEVSVEKFEHDGFWRSSMSPDQGYTTTRLFEGGPLGKKPIPEEEGLNIPDRYVLGTRVDYLHRGYSSFIMYPVRPIPIEGITKTISLWVAGRNFDHELHILIQDFFGRNFELYVGKLNFQGWKQLTVAIPPQAMNGWSGIVQRNYHYNNQMGIKIVGFRVDVDPMEAQGSYYVYLDDVRAVTDLFAEDSRDPDDMVDSW
>NC_015578.1|WP_015708983.1|3228714_3229446_-|membrane-protein
MKQGSFKAVCFVLLALIAINAAFGDENTINSTSVILESFDGDSEYDWKVMGSKFATKTDDASWPQSTVISAWPQALFGINREGKDLKSLGLWGRFDRQGFNWVDVYPVTKGGDEPAEIPIPGRIQYFDLWVWGSNLDYTIEAYFRDYQGVIHTLEMGHLNYQGWKDLQVRVPERIPQHKRVLPRLAALTFVKFRIWTPPWEQVADFRIYFDQFKIVTDTFESLFDGDELALPERVQELWNGNN
>NC_015578.1|WP_015708984.1|3229588_3230515_-|hypothetical-protein
MGFKGLIKGLVIAVLALVVVLGLGTGMFFLRSPVLMVIGDEFTGLYGLKRTRVAQIESSLKLFRRVKIVRIVDGSAPDMVAFAVEAAASKPYAALFAYSYYQGAGRYAEQFPEVPVGVLGGIKRPDTASERLVFVETDREGDFYRAGLCAARIALSEQPEGGGNSGSGGRILFITGDLITRAHRESFSRGLKDQGYDEMPRFADAGGNFTGLSGISCAVMTAPAEFYLDKDLTIPVILFSWLDPAATAREVKVIFDDSPWALGVETVKMLVRGETVPLPSKILALKDRFANTRVWRDIKKTALAKDIH
>NC_015578.1|WP_015708985.1|3230676_3231675_+|class-II-fructose-1,6-bisphosphate-aldolase
MTSYKELGLVNTVELFKKAVKGGYALPAYNFNNMEQMQAIIQASVETKSPVILQVSAGARKYANQNLLRNMAKGAVEYAHELGYDIPIVLHLDHGDSFELCKDCIETGFSSVMIDGSHLPYDENVALTKKVCEFAHSQKDYVTVEGELGVLAGVEDDVSSEHSNYTQPEEVQDFVGKTKVDSLAISIGTSHGRTKFKPEQCTRGPNGILIPPPLRFDILAEIEKRLPGFPIVLHGSSSVPQEYVEIVEKFGGKLTDSVGIPEEQLRQAAKSAVCKINVDSDGRLAMTAIIRKVFAEKPDEFDPRKYLGPARDELKKLYAHKNVNVLGSAGQA
>NC_015578.1|WP_015708986.1|3231798_3234069_+|lipoprotein
MRRFLLFIITTGLAVLFAGCGELDAVFPSQGTYRVNARVDNDHTLDEYSIVHHSSSIRPFFENSVTNDPDIRGLIVFVQNSGGTTVSRKVQYLISNDSKDQQDPAQETPAKLLVEVPPPDSTMEVLAPVLDDNLPAEVPAPDSAGEFPTETDVQNPLDPETPSESPPSKVSDSGGLKDPPPAVLSAPVSIEEPPAKLSAPASTGKLPAETDISHGAQGGGTSSEASPGKTQPVQAAGENRNNAGDPLTVQAAGQSGTSSGENPTVPDTAQAAGENRDKPGDSIMVQAAGQSGTSSEASPDSVSAAEAKVQDPPPKSDANPPRTEEQSTGSREYKDEIILVKTLEQYLPAFQILEELDIGQYNIVFQVMGDQEVLYRSFKPIYFLADADFTLGEIQSYLPATNVGKSLIPPGINVVLETEISADKRLDPYIIWQYGKKIIAQGRKSAGANYILWKTPEQPGLLNIRAEVFPLLPGDRLPANMLGKFKSLSLPVSTKVRGLKYFDEKAGTFTNWYQLWGNLEDTKAPGDTAKQLQTLADKKPRWIPHNGIYGLSTGPQDVYTLPGKPFTVSAGELGKGRILLRLAPLDGTILHAAFAAGGGLPGNAELNLSAQGETLVLELSSYGVPKDWSPENSAADTPTEDEPLRQSLTLNLNEADAYISLFIYFEIAPNRFSAKLSLENPDSETALISLPLANPLTGDSTVLLGARKKPESRSFDTNDDSSNEAAILNELALAFTQTRYEGDAFGGSAEETVSPP
>NC_015578.1|WP_015708987.1|3234116_3234803_+|hypothetical-protein
MKTSSAVISGACIIIGLVLLTTGCSTEPPRLAELGPIPKYIENNPPFELIDHENGDEDPPDWVSLYIDQGVQGIENLPEYADSYVFVSKQQGNNLEALYLWRSGFSITRDFPRLVSARIQARFIKDAPENPNGAFGRYFETVIRASSDASFSNVEQKDSYWVQKRLYAEDGVSPEEDVFESYILVSAERDTLKQQINTILRMARPEIPPTREQSAAGMRLRINFFDGF
>NC_015578.1|WP_041611215.1|3234943_3236032_+|phosphatase-PAP2-family-protein
MNGAVIISSAERLPVFFAIYRWGLAFIQGIQGIKSPGLTALMKGITALGSEYFYIPLILFIFWCVNEKKGLRLGLIILVSAFINGFFKDLLKQPRPFNLEASVGLVFEPSYGFPSGHAQLSLCFWLPLAFWLSRSRRTATCNTDFSRQVPRATCNEVPRAGKMFRAAVWGGAIFFVLLIAFTRLYLGVHFPTDILGGWFLGGLILLLWYFFRKPVTALLNAGKLRAQMIAAALIALGMNALYPADSSLGGLFLGFAAGHGLTLHYFPRSNSDEQKPSPLILAARYALGLGGAALIYLGFKTILPGENSLFSGLPLWGAGSPYFQLGRFVRYGLLGLWAAAGAPLVFLRLHLTEVSQNDGERD

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_015578_13	13.4\|3225286\|35\|NC_015578\|CRT,PILER-CR,CRISPRCasFinder	3225286-3225320	35	NZ_CP032695	Rhizobium jaguaris strain CCGE525 plasmid pRCCGE525c, complete sequence	884288-884322	7	0.8
NC_015578_3	3.1\|695395\|34\|NC_015578\|CRISPRCasFinder	695395-695428	34	NZ_CP054613	Paenibacillus cellulosilyticus strain KACC 14175 plasmid unnamed4, complete sequence	304535-304568	11	0.676

1. spacer 13.4|3225286|35|NC_015578|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP032695 (Rhizobium jaguaris strain CCGE525 plasmid pRCCGE525c, complete sequence) position: , mismatch: 7, identity: 0.8

aagtataa-ccattcaacgttgacggatatcatgaa	CRISPR spacer
-aggatagtccattcaacgtagagggatatcatgtt	Protospacer
 ** ***. *********** ** **********

2. spacer 3.1|695395|34|NC_015578|CRISPRCasFinder matches to NZ_CP054613 (Paenibacillus cellulosilyticus strain KACC 14175 plasmid unnamed4, complete sequence) position: , mismatch: 11, identity: 0.676

aaacgtagttcaataaatcttctggaattttttt	CRISPR spacer
ctggcttcttcaatacatctgctggaatttttga	Protospacer
  .  *  ******* **** ***********

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

226880 : 287352

Catovirus(22.22%)

protease,transposase,integrase

attL 230743:230759|attR 285106:285122

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015706407.1\|226880_228842_-\|protease	ATP-dependent zinc metalloprotease FtsH	C7U047	Ostreococcus_tauri_virus	1.9e-109	46.6
WP_015706409.1\|229041_231918_+	bacterial Ig-like domain-containing protein	NA	NA	NA	NA
230743:230759	attL	NA	NA	NA	NA
WP_148257205.1\|231925_234967_+	hypothetical protein	NA	NA	NA	NA
WP_015706411.1\|234968_238925_+	SUMF1/EgtB/PvdO family nonheme iron enzyme	A0A075BUR2	Microcystis_phage	2.4e-15	31.4
WP_015706412.1\|238937_239774_+	hypothetical protein	NA	NA	NA	NA
WP_041611338.1\|239854_241756_+	hypothetical protein	NA	NA	NA	NA
WP_015706414.1\|241758_243375_+	hypothetical protein	NA	NA	NA	NA
WP_174269880.1\|243465_244494_+	hypothetical protein	NA	NA	NA	NA
WP_015706416.1\|244554_245904_+	galactokinase	NA	NA	NA	NA
WP_015706417.1\|245957_247148_+	DNA polymerase IV	I6RSM4	Salmonella_phage	8.6e-17	26.7
WP_015706418.1\|247265_248966_+	hypothetical protein	NA	NA	NA	NA
WP_015706419.1\|248978_250403_+	hypothetical protein	NA	NA	NA	NA
WP_041611340.1\|250816_251935_+	S-methyl-5-thioribose-1-phosphate isomerase	NA	NA	NA	NA
WP_015706421.1\|251927_252545_+	class II aldolase/adducin family protein	NA	NA	NA	NA
WP_015706422.1\|252587_253334_+	S-methyl-5'-thioadenosine phosphorylase	NA	NA	NA	NA
WP_015706424.1\|253909_254401_+	hypothetical protein	NA	NA	NA	NA
WP_015706425.1\|254524_255451_+	FkbM family methyltransferase	NA	NA	NA	NA
WP_148257383.1\|255599_255803_+	hypothetical protein	NA	NA	NA	NA
WP_015706427.1\|256791_258108_+	hypothetical protein	NA	NA	NA	NA
WP_015706428.1\|258380_259094_+	hypothetical protein	A0A1V0S9B9	Catovirus	3.9e-41	44.2
WP_015706429.1\|259141_259918_+	glycosyl transferase	A0A2K9L639	Tupanvirus	4.6e-11	24.5
WP_015706430.1\|259941_260937_+	glycosyltransferase family 2 protein	A0A1V0SAH6	Catovirus	2.0e-14	40.7
WP_015706431.1\|260933_261893_+	UbiA prenyltransferase family protein	NA	NA	NA	NA
WP_015706432.1\|261889_262258_+	EamA family transporter	NA	NA	NA	NA
WP_015706433.1\|262263_262938_+	HAD-IA family hydrolase	NA	NA	NA	NA
WP_041610964.1\|262990_263563_+	hypothetical protein	NA	NA	NA	NA
WP_015706436.1\|263559_264981_+	hypothetical protein	NA	NA	NA	NA
WP_015706437.1\|264980_266288_+	oligosaccharide repeat unit polymerase	NA	NA	NA	NA
WP_015706438.1\|266357_267467_+	glycosyltransferase family 1 protein	NA	NA	NA	NA
WP_148257384.1\|267652_268276_+	methyltransferase	NA	NA	NA	NA
WP_015706440.1\|268297_269365_+	glycosyltransferase family 4 protein	NA	NA	NA	NA
WP_015706441.1\|269678_270644_+	glycosyltransferase	NA	NA	NA	NA
WP_015706442.1\|270686_271607_+	NAD-dependent epimerase/dehydratase family protein	NA	NA	NA	NA
WP_015706443.1\|271603_272269_+	sugar transferase	NA	NA	NA	NA
WP_015706444.1\|272285_273476_+	UDP-N-acetylglucosamine 4,6-dehydratase	NA	NA	NA	NA
WP_015706445.1\|273487_274492_+	LPS biosynthesis protein	NA	NA	NA	NA
WP_015706446.1\|274488_275949_+	SLBB domain-containing protein	NA	NA	NA	NA
WP_015706447.1\|275984_277424_+	MBOAT family protein	A0A125RNP0	Pseudomonas_phage	7.8e-89	43.3
WP_148257206.1\|277501_278572_+	hypothetical protein	NA	NA	NA	NA
WP_015706449.1\|278653_279871_+	acyltransferase	A0A2H4JA46	uncultured_Caudovirales_phage	7.0e-06	24.2
WP_015706450.1\|279936_280194_+	hypothetical protein	NA	NA	NA	NA
WP_169313397.1\|280501_281728_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_169313398.1\|281909_283148_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_015706455.1\|283285_284350_+	acyltransferase	A9YX16	Burkholderia_phage	1.5e-15	24.6
WP_052299683.1\|284521_285469_-\|transposase	transposase	NA	NA	NA	NA
285106:285122	attR	NA	NA	NA	NA
WP_052299684.1\|285432_286065_-\|transposase	transposase	NA	NA	NA	NA
WP_015706456.1\|286260_287352_-\|transposase	IS110 family transposase	NA	NA	NA	NA

DBSCAN-SWA_2

1585323 : 1623665

Bacillus_virus(12.5%)

protease,integrase

attL 1589043:1589102|attR 1597005:1597077

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015707621.1\|1585323_1586577_-\|protease	ATP-dependent Clp protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	6.1e-122	56.9
WP_015707622.1\|1586560_1587175_-\|protease	ATP-dependent Clp protease proteolytic subunit	A0A223W000	Agrobacterium_phage	2.5e-52	53.1
WP_015707623.1\|1587187_1588549_-	trigger factor	NA	NA	NA	NA
1589043:1589102	attL	NA	NA	NA	NA
WP_041611065.1\|1589572_1590019_+	hypothetical protein	NA	NA	NA	NA
WP_015707624.1\|1590343_1592476_+	AAA family ATPase	G9E4I7	Emiliania_huxleyi_virus	1.6e-05	32.4
WP_015707625.1\|1592673_1592817_+	hypothetical protein	NA	NA	NA	NA
WP_015707626.1\|1592931_1593168_+	hypothetical protein	NA	NA	NA	NA
WP_015707627.1\|1593160_1593586_+	hypothetical protein	NA	NA	NA	NA
WP_015707628.1\|1593848_1594610_-	hypothetical protein	NA	NA	NA	NA
WP_015707629.1\|1594623_1596099_-\|integrase	site-specific recombinase, phage integrase family	NA	NA	NA	NA
WP_015707630.1\|1597813_1598227_-\|protease	aspartyl protease family protein	NA	NA	NA	NA
1597005:1597077	attR	NA	NA	NA	NA
WP_015707632.1\|1598550_1601478_+	excinuclease ABC subunit UvrA	A0A1B1IVR3	uncultured_Mediterranean_phage	1.6e-311	55.8
WP_052299706.1\|1601474_1604993_+	hypothetical protein	NA	NA	NA	NA
WP_015707633.1\|1605224_1607132_+	transcription termination factor Rho	NA	NA	NA	NA
WP_015707634.1\|1607188_1607392_+	50S ribosomal protein L31	NA	NA	NA	NA
WP_052299707.1\|1607422_1608097_-	hypothetical protein	NA	NA	NA	NA
WP_015707636.1\|1608283_1608748_+	MraZ family transcriptional regulator	NA	NA	NA	NA
WP_015707637.1\|1608755_1609706_+	16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH	NA	NA	NA	NA
WP_015707638.1\|1609702_1609996_+	cell division protein FtsL	NA	NA	NA	NA
WP_015707639.1\|1610141_1611221_+	phospho-N-acetylmuramoyl-pentapeptide- transferase	NA	NA	NA	NA
WP_041611068.1\|1611217_1612354_+	putative lipid II flippase FtsW	NA	NA	NA	NA
WP_015707641.1\|1612346_1613168_+	FtsQ-type POTRA domain-containing protein	NA	NA	NA	NA
WP_015707642.1\|1613160_1614429_+	cell division protein FtsA	NA	NA	NA	NA
WP_041611069.1\|1614496_1615741_+	cell division protein FtsZ	NA	NA	NA	NA
WP_041611070.1\|1615741_1616656_+	tyrosine recombinase	G1JX48	Mycobacterium_phage	3.6e-15	29.1
WP_015707645.1\|1616663_1617410_+	hypothetical protein	NA	NA	NA	NA
WP_015707646.1\|1617402_1618383_+	DNA-protecting protein DprA	NA	NA	NA	NA
WP_015707647.1\|1618389_1620558_+	type I DNA topoisomerase	A0A1V0SCS0	Indivirus	4.3e-91	35.0
WP_015707648.1\|1620547_1621516_+	tyrosine recombinase	A0A0K2CP59	Brevibacillus_phage	4.4e-27	28.1
WP_015707649.1\|1621512_1622085_+\|protease	ATP-dependent protease subunit HslV	NA	NA	NA	NA
WP_015707650.1\|1622084_1623665_+\|protease	ATP-dependent protease ATPase subunit HslU	A0A191ZC11	Erwinia_phage	3.4e-37	27.9

DBSCAN-SWA_3

1833067 : 1844398

Enterobacteria_phage(27.27%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015707812.1\|1833067_1834282_-\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	1.8e-49	47.0
WP_015707813.1\|1834293_1835361_-	glycosyltransferase family 2 protein	A0A1V0SAH6	Catovirus	8.9e-13	33.9
WP_015707814.1\|1835373_1836393_-	hypothetical protein	E3SJ78	Synechococcus_phage	5.0e-21	33.2
WP_015707815.1\|1836404_1837325_-	glycosyltransferase	NA	NA	NA	NA
WP_041611084.1\|1837330_1838290_-	GDP-L-fucose synthase	M4R1H4	Synechococcus_phage	3.2e-94	54.4
WP_015707817.1\|1838282_1839368_-	GDP-mannose 4,6-dehydratase	M1IBC3	Acanthocystis_turfacea_Chlorella_virus	1.3e-133	65.5
WP_015707818.1\|1839384_1840347_-	SDR family oxidoreductase	A0A2K9KZK0	Tupanvirus	3.8e-87	49.8
WP_041611085.1\|1840374_1841463_-	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	1.7e-75	44.8
WP_015707820.1\|1841450_1842338_-	dTDP-4-dehydrorhamnose reductase	A0A291LA50	Escherichia_phage	6.9e-35	34.1
WP_015707821.1\|1842334_1842868_-	dTDP-4-dehydrorhamnose 3,5-epimerase	I7HJC4	Enterobacteria_phage	1.1e-48	55.0
WP_015707822.1\|1842867_1843743_-	glucose-1-phosphate thymidylyltransferase RfbA	I7I009	Enterobacteria_phage	2.5e-98	59.3
WP_081468708.1\|1843750_1844398_-	CatB-related O-acetyltransferase	A0A285PXQ2	Cedratvirus	4.3e-10	47.1

DBSCAN-SWA_4

2125574 : 2182868

Hokovirus(28.57%)

protease,terminase,portal,capsid,transposase,integrase,head

attL 2122428:2122451|attR 2186528:2186551

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2122428:2122451	attL	NA	NA	NA	NA
WP_015708082.1\|2125574_2126795_+\|terminase	terminase	S5VY04	Leptospira_phage	2.5e-43	33.6
WP_015708083.1\|2126791_2128021_+\|portal	phage portal protein	NA	NA	NA	NA
WP_015708084.1\|2128024_2128726_+	response regulator transcription factor	NA	NA	NA	NA
WP_015708085.1\|2128719_2129388_+\|head,protease	HK97 family phage prohead protease	H9YSG6	environmental_Halophage	3.9e-06	27.9
WP_015708086.1\|2129456_2130758_+\|capsid	phage major capsid protein	NA	NA	NA	NA
WP_015708087.1\|2130882_2132121_-\|integrase	site-specific integrase	S6C485	Thermus_phage	4.6e-05	21.2
WP_015708088.1\|2132375_2150243_-	Ig-like domain repeat protein	NA	NA	NA	NA
WP_015708089.1\|2150351_2152667_-	hypothetical protein	NA	NA	NA	NA
WP_015708091.1\|2152838_2153969_-	hypothetical protein	NA	NA	NA	NA
WP_015708092.1\|2154053_2169251_-	lipoprotein	NA	NA	NA	NA
WP_015708093.1\|2169491_2170757_+	HlyC/CorC family transporter	NA	NA	NA	NA
WP_015708094.1\|2170753_2171158_+	(deoxy)nucleoside triphosphate pyrophosphohydrolase	NA	NA	NA	NA
WP_015708095.1\|2171347_2171605_+	hypothetical protein	NA	NA	NA	NA
WP_015708097.1\|2171965_2176516_+	response regulator	A0A1V0SGX0	Hokovirus	4.6e-42	27.9
WP_015708098.1\|2176505_2179028_+	response regulator	A0A1V0SGX0	Hokovirus	1.4e-40	32.0
WP_015708099.1\|2179031_2180321_+	response regulator	A0A2H4N7Z5	Lake_Baikal_phage	7.4e-38	38.4
WP_148257279.1\|2180560_2181121_+	hypothetical protein	NA	NA	NA	NA
WP_041611118.1\|2181117_2181528_+	(deoxy)nucleoside triphosphate pyrophosphohydrolase	NA	NA	NA	NA
WP_015707812.1\|2181653_2182868_-\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	1.8e-49	47.0
2186528:2186551	attR	NA	NA	NA	NA

DBSCAN-SWA_5

2217486 : 2301294

Bacillus_virus(27.27%)

protease,terminase,portal,capsid,transposase,tRNA,integrase,head

attL 2219948:2219963|attR 2231553:2231568

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015708140.1\|2217486_2218791_-\|capsid	phage major capsid protein	NA	NA	NA	NA
WP_015708141.1\|2218859_2219555_-\|head,protease	HK97 family phage prohead protease	NA	NA	NA	NA
WP_015708142.1\|2219535_2220258_-	response regulator transcription factor	NA	NA	NA	NA
2219948:2219963	attL	NA	NA	NA	NA
WP_041611127.1\|2220247_2221498_-\|portal	phage portal protein	NA	NA	NA	NA
WP_015708144.1\|2221494_2222730_-\|terminase	terminase	S5VY04	Leptospira_phage	1.4e-38	31.5
WP_015708145.1\|2222732_2223269_-	hypothetical protein	NA	NA	NA	NA
WP_015708146.1\|2223252_2223579_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_148257284.1\|2223708_2225148_-\|integrase	tyrosine-type recombinase/integrase	A0A1B0T6A8	Bacillus_phage	4.0e-08	24.3
WP_015708148.1\|2225886_2244411_+	hypothetical protein	NA	NA	NA	NA
2231553:2231568	attR	NA	NA	NA	NA
WP_015708149.1\|2244492_2245524_+	hypothetical protein	NA	NA	NA	NA
WP_015708150.1\|2245501_2249899_+	Ig-like domain-containing protein	NA	NA	NA	NA
WP_015708151.1\|2249917_2251879_+	hypothetical protein	NA	NA	NA	NA
WP_015708152.1\|2251875_2253201_+	extracellular solute-binding protein	NA	NA	NA	NA
WP_015708153.1\|2253206_2253875_-	hypothetical protein	NA	NA	NA	NA
WP_015708154.1\|2253876_2255142_-	hypothetical protein	NA	NA	NA	NA
WP_174269883.1\|2255151_2256075_-	alpha/beta hydrolase fold domain-containing protein	NA	NA	NA	NA
WP_169313444.1\|2256409_2256856_-	DUF192 domain-containing protein	A0A1B1IUW8	uncultured_Mediterranean_phage	1.6e-11	41.8
WP_015708157.1\|2256887_2257595_-	hypothetical protein	NA	NA	NA	NA
WP_041611128.1\|2257729_2258962_-	cyclic nucleotide-binding domain-containing protein	NA	NA	NA	NA
WP_148257285.1\|2259057_2260056_-	UDP-N-acetylmuramate dehydrogenase	NA	NA	NA	NA
WP_081468655.1\|2260024_2262274_-	hypothetical protein	NA	NA	NA	NA
WP_015708162.1\|2262384_2262966_+	DUF4398 domain-containing protein	NA	NA	NA	NA
WP_015708164.1\|2263639_2267203_+	pyruvate:ferredoxin (flavodoxin) oxidoreductase	NA	NA	NA	NA
WP_015708165.1\|2267514_2269047_+	hypothetical protein	NA	NA	NA	NA
WP_015708166.1\|2269056_2270355_+	glycosyltransferase family 4 protein	NA	NA	NA	NA
WP_041611595.1\|2270424_2271033_+	HAD-IA family hydrolase	NA	NA	NA	NA
WP_015708168.1\|2271057_2273616_+	response regulator	A0A1V0SGX0	Hokovirus	1.2e-42	31.4
WP_052299714.1\|2273677_2277232_+	response regulator	A0A1V0SGX0	Hokovirus	1.3e-39	26.8
WP_015708170.1\|2277253_2277958_+	PHP domain-containing protein	NA	NA	NA	NA
WP_015708171.1\|2278309_2279359_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_148257448.1\|2279521_2281234_+	ABC transporter permease subunit	NA	NA	NA	NA
WP_015708173.1\|2281226_2282366_+	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	7.7e-31	36.0
WP_015708174.1\|2282652_2283735_+	hypothetical protein	NA	NA	NA	NA
WP_015708175.1\|2283731_2284499_+	HAD family hydrolase	M1HXP3	Paramecium_bursaria_Chlorella_virus	3.7e-05	25.3
WP_015708176.1\|2284491_2285262_+	HAD-IA family hydrolase	NA	NA	NA	NA
WP_015708177.1\|2285308_2287174_+	iron ABC transporter permease	NA	NA	NA	NA
WP_015708178.1\|2287238_2288360_+	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	1.6e-28	33.8
WP_015708179.1\|2288381_2289578_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_015708181.1\|2290210_2291275_+	LacI family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_015708182.1\|2291258_2292152_+	ribokinase	NA	NA	NA	NA
WP_015708183.1\|2292179_2292881_+	MgtC/SapB family protein	G3MA03	Bacillus_virus	4.4e-21	45.5
WP_041611604.1\|2292942_2293788_+	nucleoside triphosphate pyrophosphohydrolase	NA	NA	NA	NA
WP_015708185.1\|2293810_2294785_-	hydroxyacid dehydrogenase	M1I636	Acanthocystis_turfacea_Chlorella_virus	7.6e-19	30.6
WP_015708186.1\|2294800_2295424_-\|tRNA	aminoacyl-tRNA hydrolase	NA	NA	NA	NA
WP_015708187.1\|2295495_2297352_+	alpha-galactosidase	NA	NA	NA	NA
WP_015708188.1\|2297352_2299005_+	putative manganese-dependent inorganic diphosphatase	NA	NA	NA	NA
WP_015708189.1\|2299263_2300076_+	MerR family transcriptional regulator	NA	NA	NA	NA
WP_015708190.1\|2300238_2301294_+\|transposase	IS481 family transposase	E9P643	Wolbachia_endosymbiont_wVitB_of_Nasonia_vitripennis_phage	1.1e-132	65.1

DBSCAN-SWA_6

3433879 : 3440428

uncultured_Mediterranean_phage(28.57%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_041611237.1\|3433879_3434833_+	DUF932 domain-containing protein	A0A1B1INH0	uncultured_Mediterranean_phage	6.9e-33	34.3
WP_041611238.1\|3434920_3435469_+	hypothetical protein	A0MN47	Thermus_phage	1.5e-27	40.4
WP_015709155.1\|3435541_3435766_+	hypothetical protein	A0A2I7S8R6	Vibrio_phage	1.5e-07	47.1
WP_015709156.1\|3435755_3436004_+	hypothetical protein	NA	NA	NA	NA
WP_015709157.1\|3436005_3436485_+	hypothetical protein	A0A1L7N1D2	Ralstonia_phage	2.5e-07	42.9
WP_015709158.1\|3436484_3437363_+	PD-(D/E)XK nuclease family protein	A0A1B1ITH1	uncultured_Mediterranean_phage	1.2e-28	29.7
WP_015709159.1\|3437377_3437587_+	hypothetical protein	NA	NA	NA	NA
WP_015709160.1\|3437586_3437784_+	hypothetical protein	NA	NA	NA	NA
WP_015709161.1\|3438063_3439125_+	ATP-binding protein	A0A2P1CHM4	Mycobacterium_phage	4.3e-44	41.6
WP_015709162.1\|3439197_3439968_+	hypothetical protein	NA	NA	NA	NA
WP_015709163.1\|3440032_3440428_+	single-stranded DNA-binding protein	A0A2H4J1H8	uncultured_Caudovirales_phage	6.4e-09	30.3

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_015578

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection