CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_015690	Paenibacillus mucilaginosus KNP414, complete sequence	25 crisprs	WYL,csa3,cas3,DEDDh,DinG,RT	5	12	4	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_015690_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015690_1

583611-583887

Orphan

Consensus_repeat	Method
TTATTATGCGGAAGTGGCTCAGCGGTAGAGCATCGCCTTGCCAAGGCGAGGGT	PILER-CR

2 spacers

The CRISPR arrays of NC_015690_1

>merge|NC_015690|1|583611-583887|PILER-CR
TGCGGAAGTGGCTCAGCGGTAGAGCATCGCCTTGCCAAGGCGAGGGTCGCGGGTTCGATTCCCGTCTTCCGCTCCATCATTTTCATCTGGCGCAGTACAAGATTTTATGTTATTATGCGGAAGTGGCTCAGCGGTAGAGCATCGCCTTGCCAAGGCGAGGGTCGCGGGTTCGATTCCCGTCTTCCGCTCCATCATTTTCATCTGGCGCAGTACAAGATTTTATGTTATTATGCGGAAGTGGCTCAGCGGTAGAGCATCGCCTTGCCAAGGCGAGGGT

>NC_015690|1|1|583611-583887|PILER-CR
TGCGGAAGTGGCTCAGCGGTAGAGCATCGCCTTGCCAAGGCGAGGGTCGCGGGTT	CGATTCCCGTCTTCCGCTCCATCATTTTCATCTGGCGCAGTACAAGATTTTATGTTATTATG
CGGAAGTGGCTCAGCGGTAGAGCATCGCCTTGCCAAGGCGAGGGTCGCGGGTTCG	ATTCCCGTCTTCCGCTCCATCATTTTCATCTGGCGCAGTACAAGATTTTATGTTATTATG
CGGAAGTGGCTCAGCGGTAGAGCATCGCCTTGCCAAGGCGAGGGT

Protein	Signature genes	Signature genes Name	Protein_function
NC_015690.1\|WP_013914350.1\|589956_590940_+\|sugar-kinase	unknown	unknown	gnl\|CDD\|238571
NC_015690.1\|WP_014368329.1\|572585_573734_+\|D-alanine--D-alanine-ligase	unknown	unknown	gnl\|CDD\|234993
NC_015690.1\|WP_013914349.1\|589201_589957_+\|2-dehydro-3-deoxy-D-gluconate-5-dehydrogenase-KduD	unknown	unknown	gnl\|CDD\|180761
NC_015690.1\|WP_041616485.1\|574361_575354_+\|UV-DNA-damage-repair-endonuclease-UvsE	unknown	unknown	gnl\|CDD\|235029
NC_015690.1\|WP_013914333.1\|564531_565809_-\|DUF2935-domain-containing-protein	unknown	unknown	gnl\|CDD\|223678
NC_015690.1\|WP_013914348.1\|588233_589091_+\|malonyl-ACP-O-methyltransferase-BioC	unknown	unknown	gnl\|CDD\|273953
NC_015690.1\|WP_013914344.1\|584462_585218_+\|dethiobiotin-synthase	unknown	unknown	gnl\|CDD\|234625
NC_015690.1\|WP_081473132.1\|587431_588256_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NC_015690.1\|WP_013914338.1\|571441_572467_+\|amidase-domain-containing-protein	unknown	unknown	gnl\|CDD\|378910
NC_015690.1\|WP_187296758.1\|593143_597682_-\|glutamate-synthase	unknown	unknown	gnl\|CDD\|239202
NC_015690.1\|WP_041617701.1\|586292_587435_+\|8-amino-7-oxononanoate-synthase	unknown	unknown	gnl\|CDD\|235655
NC_015690.1\|WP_013914342.1\|575472_576240_+\|enoyl-ACP-reductase-FabI	unknown	unknown	gnl\|CDD\|236308
NC_015690.1\|WP_013914337.1\|568491_571197_-\|aconitate-hydratase-AcnA	unknown	unknown	gnl\|CDD\|236445
NC_015690.1\|WP_013914343.1\|576409_577270_+\|inositol-monophosphatase	unknown	unknown	gnl\|CDD\|238817
NC_015690.1\|WP_013914340.1\|573836_574154_+\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013914351.1\|590956_591619_+\|bifunctional-2-keto-4-hydroxyglutarate-aldolase/2-keto-3-deoxy-6-phosphogluconate-aldolase	unknown	unknown	gnl\|CDD\|180618
NC_015690.1\|WP_013914334.1\|565907_566936_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|366166
NC_015690.1\|WP_013914353.1\|598307_599648_-\|glutamate-1-semialdehyde-2,1-aminomutase	unknown	unknown	gnl\|CDD\|183493
NC_015690.1\|WP_013914336.1\|567552_568296_+\|IclR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224332
NC_015690.1\|WP_013914345.1\|585258_586251_+\|biotin-synthase-BioB	unknown	unknown	gnl\|CDD\|235755

Protein	Function_ID	Function_description	E-value
NC_015690.1\|WP_013914350.1\|589956_590940_+\|sugar-kinase	gnl\|CDD\|238571	cd01166, KdgK, 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the glycolysis and therefore use polymers, like pectin and xylan as carbon sources.	8.01471e-110
NC_015690.1\|WP_014368329.1\|572585_573734_+\|D-alanine--D-alanine-ligase	gnl\|CDD\|234993	PRK01966, ddl, D-alanine--D-alanine ligase.	7.67438e-179
NC_015690.1\|WP_013914351.1\|590956_591619_+\|bifunctional-2-keto-4-hydroxyglutarate-aldolase/2-keto-3-deoxy-6-phosphogluconate-aldolase	gnl\|CDD\|180618	PRK06552, PRK06552, keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase; Provisional.	2.21056e-102
NC_015690.1\|WP_041616485.1\|574361_575354_+\|UV-DNA-damage-repair-endonuclease-UvsE	gnl\|CDD\|235029	PRK02308, uvsE, putative UV damage endonuclease; Provisional.	6.28528e-134
NC_015690.1\|WP_013914333.1\|564531_565809_-\|DUF2935-domain-containing-protein	gnl\|CDD\|223678	COG0605, SodA, Superoxide dismutase [Inorganic ion transport and metabolism].	6.73325e-86
NC_015690.1\|WP_013914348.1\|588233_589091_+\|malonyl-ACP-O-methyltransferase-BioC	gnl\|CDD\|273953	TIGR02072, Malonyl-_O-methyltransferase, malonyl-acyl carrier protein O-methyltransferase BioC. This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin].	6.3192e-66
NC_015690.1\|WP_013914344.1\|584462_585218_+\|dethiobiotin-synthase	gnl\|CDD\|234625	PRK00090, bioD, ATP-dependent dethiobiotin synthetase BioD.	6.78282e-77
NC_015690.1\|WP_013914349.1\|589201_589957_+\|2-dehydro-3-deoxy-D-gluconate-5-dehydrogenase-KduD	gnl\|CDD\|180761	PRK06935, PRK06935, 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase KduD.	2.02443e-129
NC_015690.1\|WP_013914338.1\|571441_572467_+\|amidase-domain-containing-protein	gnl\|CDD\|378910	pfam12671, Amidase_6, Putative amidase domain.	1.1166e-45
NC_015690.1\|WP_187296758.1\|593143_597682_-\|glutamate-synthase	gnl\|CDD\|239202	cd02808, GltS_FMN, Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast and bacterial pathway for ammonia assimilation. It is a multifunctional enzyme that functions through three distinct active centers, carrying out L-glutamine hydrolysis, conversion of 2-oxoglutarate into L-glutamate, and electron uptake from an electron donor.	6.57333e-122
NC_015690.1\|WP_041617701.1\|586292_587435_+\|8-amino-7-oxononanoate-synthase	gnl\|CDD\|235655	PRK05958, PRK05958, 8-amino-7-oxononanoate synthase; Reviewed.	8.23044e-165
NC_015690.1\|WP_013914342.1\|575472_576240_+\|enoyl-ACP-reductase-FabI	gnl\|CDD\|236308	PRK08594, PRK08594, enoyl-[acyl-carrier-protein] reductase FabI.	4.56529e-143
NC_015690.1\|WP_013914337.1\|568491_571197_-\|aconitate-hydratase-AcnA	gnl\|CDD\|236445	PRK09277, PRK09277, aconitate hydratase AcnA.	0
NC_015690.1\|WP_013914343.1\|576409_577270_+\|inositol-monophosphatase	gnl\|CDD\|238817	cd01639, IMPase, IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be recycled into inositol lipids; in eukaryotes IMPase plays a vital role in intracellular signaling. IMPase is one of the proposed targets of Li+ therapy in manic-depressive illness. This family contains some bacterial members of the inositol monophosphatase family classified as SuhB-like. E. coli SuhB has been suggested to participate in posstranscriptional control of gene expression, and its inositol monophosphatase activity doesn't appear to be sufficient for its cellular function. It has been proposed, that SuhB plays a role in the biosynthesis of phosphatidylinositol in mycobacteria.	8.84388e-108
NC_015690.1\|WP_081473132.1\|587431_588256_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	2.61289e-09
NC_015690.1\|WP_013914334.1\|565907_566936_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	1.28015e-11
NC_015690.1\|WP_013914353.1\|598307_599648_-\|glutamate-1-semialdehyde-2,1-aminomutase	gnl\|CDD\|183493	PRK12389, PRK12389, glutamate-1-semialdehyde aminotransferase; Provisional.	0
NC_015690.1\|WP_013914336.1\|567552_568296_+\|IclR-family-transcriptional-regulator	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	2.13333e-65
NC_015690.1\|WP_013914345.1\|585258_586251_+\|biotin-synthase-BioB	gnl\|CDD\|235755	PRK06256, PRK06256, biotin synthase; Validated.	0

>NC_015690.1|WP_013914343.1|576409_577270_+|inositol-monophosphatase
MSTSNIPAFAVGSKSFTAVAINTASKAGEWIQSKVGDFSSLHTKYSAQDLVTEVDKGAEKMIRNLILTHFPGHSILGEEGVEPGPEASQRALEEASSAEYLWIVDPLDGTTNFVHGFPFFSVSIALAYKGEVIVGVVYNPIHNELYVAEKGKGAYLKGRKMEVSPEKTLGESLIATGFPADRDGTLPANLRGVQALSPKVRNMRVAGSAALHMAYVAAGRLSGFYEIGLNSWDMAAGALLIEESGGKVTDTLGNPYHLGVRHVVASNGHIHDELQKELAAASATGY
>NC_015690.1|WP_013914342.1|575472_576240_+|enoyl-ACP-reductase-FabI
MSLVAGKNIVVMGVANDRSIAWAIAQSLAAQGARLVFTYENERVEERVRKLAGTIEGASILPCNVTDDADIDRLAENLREQFGVLHGIVHSIAFARTEELEGMFVNTSRDGFALAHDISAYSLVAVAQKLYPLMTEGGSVMTMTYLGAERALKNYNVMGVAKAALEASVRYLANDLGQFNIRVNAISAGPIRTLAAKGIKDFNSILKTVEEKAPLRRTTEAAEVGDTALFLMSNLSRGITGEVIYVDSGYHIIGV
>NC_015690.1|WP_041616485.1|574361_575354_+|UV-DNA-damage-repair-endonuclease-UvsE
MIVRLGYVAMSVMVKNASPSKTMTYTHFEKLGDREAAIRKLERIASENIRNTLRLLKHNRAYDIEMYRISSKLIPLLGHEGLGDWDPIERLSGDFAELGQYAKDNRMRLSFHPDHFTVFSTPREDVLRSSRTDLDRHVRMLEAMGLDASAKCNIHVGGTYGNKDSARARFLEQFGALPERIRERMTLENDDKTFNALETLEICEEAGVPMVLDIHHDAVNPGEVPAAELWPRILQTWKGQKEQEDGSGSPRDLPPKIHVSSPKSESDPRGHADYIETGVFMDFVRAVAPLTPRLDVMLEAKMKDGSLIQLAEDLKKEPNITMLSQASFEI
>NC_015690.1|WP_013914340.1|573836_574154_+|hypothetical-protein
MGFQTEFNSVCKFKSEQELYELLEYGRGKMVKSGFRVFPAGQKVIAYTPGNQAIAIVKILASIAEINFQGEEVTQVEMELVRRLTEEEARIQTALAHEMFFGEQE
>NC_015690.1|WP_014368329.1|572585_573734_+|D-alanine--D-alanine-ligase
MSKIRVGLIYGGKSGEHEVSLQTALAVTKALDLSKYEVQPFYITKEGDWRSGPQLTAPADSVDALTFGSASSSNETGTFALQPLFGSSAAAKASGNPAVSGSESGAAAGPLDVVLPLLHGTFGEDGTVQGLLEMANIAYVGTGVLASAVGMDKVMMKKVFAQEGLPQCVFRHFTKSQWEKDNAFFIMEIEVAIGYPCFVKPANLGSSVGINKARNRDELLSAIAEAFRYDRKVIVEEFIDARELEVAVLGNDEPQASVVGEIVSSGEFYDYKAKYIDGKSSMIIPAEIDSEQASRIRDLAVRAFQSIDGTGLSRVDFFLRKDNGEIYINEINTMPGFTPFSMYPLLWRESGKPYSELLDDLVRLAIQRHEEKQRLQYSFDLT
>NC_015690.1|WP_013914338.1|571441_572467_+|amidase-domain-containing-protein
MSWRTTLYDYVHHRNRMDIEHSVEPMLPFVSDEAYLSAERSRLARRLDSDRERGLLPVKTETRLSIRQTVPYKNGIAADCVLKRIAVGQIGLEAYEEQRVEQERICLAPSPDGEAWTIQRVEPLLGEQRLRLKTAHPGALLEADDEFEHVGLMRAPSVPLLGPGVAPLAGTASRRSYNRGEAVRYADKWWDGNNPAYIAFEVDCTSYISQCLFAGGAPMNYTDRRDAGWWYKGRLGGQELWSFSWAVAESLQFYLRTSRSGLRGQEVVSAGELEPGDVIAYDWDGDGRFQHSTIVTAKDANGMPLVNAHTVSSRRRYWDYRDSHAWTTRTQYRFIHISDAL
>NC_015690.1|WP_013914337.1|568491_571197_-|aconitate-hydratase-AcnA
MSNQDQFSVRKQLEVGGKTYNYYSLQAFQEQGSDISNLPFSIKVLLEAALRQFDGKAITEEHVKQIASWASDRDPNKEIPFIPARIVLQDFTGVPVVVDLAAMRDTMKRAGGDPKRINPLVPVDLVIDHSVMVDAFGSKDALEFNEKIEFERNEERYRFLRWAQTAFDNFRAVPPDTGIVHQVNLEYLASVAATRTINGEEFVFPDSLVGTDSHTTMINGLGIVGWGVGGIEAEAGMLGQPLYFVTPEVIGFKLTGTLSEGATATDLALTVTQMLRKKGVVGKFVEFYGPGLSNISLADRATVANMAPEYGATIGFFPVDQESLYFLRNTGRSEEQIALVEAYYKEQGLFRTNDTPDPVFSDVLELDLGSVVPSLAGPKRPQDRVELTNMKESFNSIIRTPIDKGGYGLSDEKIAEVVDVPHVNGEVSKMGTGAVVIAAITSCTNTSNPSVMLGAGLVAKKAVARGLRKPGYVKSSLTPGSLVVTEYLRKAGLLESLEALGFHVAGYGCATCIGNSGPLPEEVSRAIADNDMTVAAVLSGNRNFEGRVHAQVKANYLASPPLVVAYALAGTVNIDLANDPIGYDQKNEPVYLKDIWPTAQEIAEAFTQGMSADLYREKYANVFRSNERFNAINVPEGELYEWDDNSTYIANPPFFENLGAELNDIADIRGAKTLLLLGDSVTTDHISPAGNIKPDSPAGKFLMEHGVKKEDFNSYGSRRGNHDVMMRGTFANIRIRNQVAPGTEGGVTTYLPTGEVMSVYDASMKYQEQGTNLVVIAGKEYGTGSSRDWAAKGTFLLGVKAVIAESFERIHRSNLVGMGVLPLQFQEGQGWSTLGLTGTETFDIVGLSNDVQPGQKVTVNVTREDGTSFSFEVIARLDSYVDVDYYRNGGILQTVLRQIMA
>NC_015690.1|WP_013914336.1|567552_568296_+|IclR-family-transcriptional-regulator
MEDGKLTVRAVERALDILLCFTEAEDLSLTEISARVGLHKSTVHRLLASLEGKGFIIRHPATERYRLGFRIWELSANLTHSDDPAVILLPELERLRDQLGETVSLYVRDGLERVRVQAVQSNQAIRRVAPIGARLPLYVGASSKVLVAFADPAEQQALLADPAWPPASDPAAYEQQLAEVRSLGYATSVEEREPGAAAVSVPVFDRAEKLVAALAVSGPSNRLTVELMKEHAPLLMDAARRMGKMLR
>NC_015690.1|WP_013914334.1|565907_566936_-|alpha/beta-fold-hydrolase
METNSSSSYSSVPINPTTVETAVRRTFVRRHKGLLIGLLSVLLLLFSLLMAFHAYIAWTLARPHIDPLRSNPALSIGTAYEDITFPSLNGSSTLSGWYIPSEMESANSRKTVVFSHGYGGNREEIWVPIYDLAKAAHKMGFNVVMFDYGYVQPDWNVTGGLRESQELLGAVQYAKDRGADRVYVWGFSMGAGTALQAALLTKDIDGMILDSTFVLEPETLYHNMKQVANLPKFSQGLVHMFFPLLNGVSLNQVPYQTVKETKYDIPIFFIHGKEDLKAPWNMVESIYQLQKDQSGSQLWLLEKDGHELIYRAHKKTYLQMTTGFLQTLSTGSPEVVKHGQSR
>NC_015690.1|WP_013914333.1|564531_565809_-|DUF2935-domain-containing-protein
MQYAYGALTPLRLLEETRFWKGQEREHTVVIRELAPALEPDYKRLLQEWEVVLARAETSAGRWIEALLRRPAPASPALRQEVRRFLEASAVQSQAFVRQLHLLMERSRTIRTQPPLRAILLHLIRESEYFLGVLQAAAGGPGAYEEGLSGGSFAPDDAQTGQEGQGGSDGHPLSAHDTGGDPSEAQPPEEPYDSSGATATQEGVWTMGIRPVPAYAKPVPIGGHRLPPLPYPYDALEPHIDKETMRLHHTKHHLSYVEGLNKAELALARAREIGDYALVKHWERETAFHGAGHYLHTLFWQVMKPGGGGPPTGTIAADLKKSFGGFSPFRKQFSAAAEKVEGGGWALLVWSPRSHRLEILQAEKHQNLSQWDVIPLLVLDVWEHAYYVRYRNDRARYIEAWWNTIHWEHVNERLEAARGLKWPPF
>NC_015690.1|WP_013914344.1|584462_585218_+|dethiobiotin-synthase
MGKGLFVTGTDTEVGKTWVTSLLAAAAARRISLHNAGQGTVLSNPLHLWKPIQSGSQPGDPRADSFRLLRGSGIEQTEEETVTYSLKAPLAPWMAARRAGTLIPWEELLAEGERKLASYPRLLVEGAGGLLVPLTERYTVADLAAAMGLPLLIVARTRLGTVNHTLLTIEAARQRGLRIAGVLLNGYPGDDDLALSETIEMIEQLGSVPVLGVFPQLEEEPVSMEEWEAWRDQWIEIVESRIRMDEIMSFF
>NC_015690.1|WP_013914345.1|585258_586251_+|biotin-synthase-BioB
MVTTYTNWSELAKKAIQGERLTMRESLELLEAPDDELLRIMDAAFQVRRHYYGKKVKLNLIINAKSGLCPEDCGYCSQSIVSKAAITKYPLLEKDTLVDGARKAMELKVGTYCIVASGRGPTGRELDQVVEAVKEIKSTMPMKICACLGILSEEQAVKLKEAGVDRYNHNLNTSKANFGNITTTHTYDDRVETVEKAKAAGMSPCSGCIIGMGETNEEIVEMAYALRELDADSIPVNFLNSIPGTPLENRRDLDPRHCLKVLALIRLICPTKEIRVAGGREVNLRSMQALALYAANSVFVGDYLTTEGQEATADHQMIEDMGFEIELCAL
>NC_015690.1|WP_041617701.1|586292_587435_+|8-amino-7-oxononanoate-synthase
MHKELESLRERQQFRSITDSEPQPDGWVIRSGQRMLNLASNQYLGMDWAWAAPGLETASAGMGAGASRLVTGNHPLCTRLEQEFARFKGTESCLLLSSGYMANIGVIPALVGRSDCIFSDRLNHASIMDGIVLSRAECRRYPHRDLDRLEAQLKKTSAGARKLIVTDSIFSMDGSIAPLRELVELKDRYGAMLMVDEAHSGGLYSEEGQGLIHSLGLTDRVEIQMGTFSKAYGAYGAYIAGDALLKEYLTNKVRSLIFTTALPPAVISAVYRSWQSVKGHHLRRAELQRKAALFRQRLQEAGFDTGESECHIVPLVLGSNEKALKVSEKLQQEGIAAVAIRPPTVPEGKARIRFSLMATHSDEDLQWAIERIIRIGREEG
>NC_015690.1|WP_081473132.1|587431_588256_+|alpha/beta-hydrolase
MTLPQIMPSILWVHGWGMSPNIWPHAIGTDIAEPIGQPEALLPGWRHSYFTYEGCSTGEQMVRHLHSRLSEEKPDAVVGWSLGGMLLLRCLADELRSGRQLPMGVRGRMPLVILAGSTLRFIHPDRNCGWPRRIVERMRAKAEAEPWAVGDQFASAMLTGRMHETRLVDQVKASWGATDFSREGLYAGLSYLIEEDLRTAWLEILTPALKSGALHLLWLQGEEDGICPIGAVPDTGEGWQKAVFPRTGHLPFLERTPEFYQRIKEFLHEYLEYR
>NC_015690.1|WP_013914348.1|588233_589091_+|malonyl-ACP-O-methyltransferase-BioC
MNTWSIDKKRVRRHFDRHAHEYDLYAEVQRRMTDELMSRLLERRRGPHVGRIVEIGCGTGQLTQKLLQAYPEAEVTAIDLSPKMAEVTRLRCAPWAGERLTVLAADAETLLMSPFCTPDRLSGFDLVVSSAAFQWFTDTQKTLTSWLGRIRQEGLLAFATFGPETFRELHGAFRQAEIRLGIPHQASGQQFADREEWQRLLLPCGESAWELDWDEERVIQRFDNVRSFLDSVKRVGAANSVQDGRAGFSMARKRIELMTEAYSRAYGGEGIPATYHIYYGMFGKR
>NC_015690.1|WP_013914349.1|589201_589957_+|2-dehydro-3-deoxy-D-gluconate-5-dehydrogenase-KduD
MNLFDLTGKVALVTGGAVGLGGGISLGLAKAGADIVIVTSNDRSREVQQEIEAMGRKVHTIVANLMDEQALKGVVEEALSVFGKIDILVNNSGIIRRTPAAEHGAQDWHDVLNLNLNSAFFLCQLVGREMIKQGSGKIINIASLLSFQGGINVPGYTASKHAIAGVTKALANEWASKGVQVNAIAPGYMSTDNTAALRADEERSSQILVRIPAARWGTTEDLQGPVIFLASAASDYMNGHVLAVDGGWMAR
>NC_015690.1|WP_013914350.1|589956_590940_+|sugar-kinase
MAESGQTQEHQMFRPEIITFGETMALIMPEGSKGIEYSSSFQGLFGGAESNVAIGVSRLGHRAGWFSRLGKDPFGRMILKKIRGEGVDVSRTELTTEAPTGLMLREVVSGKTSVYYYRKGSAASLLRPEHLDEEYIAQAKYLHVTGITAALSESCRATLREAIRLAKKHGVKICFDPNLRLKLWSIEEARGVLLELAQEADYFLPGLDELKLLYQTESFDEIVAKLSELKAISIVKGGEDETYVVENGEVSAVPYFKAERVVDTVGAGDGFCAGFFVGLLKGYTHVEAVRLGNLIGCMVVQMEGDWEGIPTWEQVEAFLNNVKHVER
>NC_015690.1|WP_013914351.1|590956_591619_+|bifunctional-2-keto-4-hydroxyglutarate-aldolase/2-keto-3-deoxy-6-phosphogluconate-aldolase
MKKLQLVQKIVNEGVVAVLRGDTPDEVVEMAEQAIEGGIKVIEVTMTVPFALQAIEKLAKKYSSTTDDPSRYAIIGVGTVLDPETARAAILSGSEFVVGPSLNPDTITLCNRYRVPVMPGVMTIQEIQRALELGVDVVKLFPGNLYSPSMIKAIKGPLPQANVMPTGGVSLDNLGEWIKAGAVAVGIGSDLTTEAVKQRDYSLVAKKAAQYVAAYRAAKA
>NC_015690.1|WP_187296758.1|593143_597682_-|glutamate-synthase
MRDEGRFQNLLATEHDSCGIICIVEKDGFPSRDNIQKTIEALVKMEHRSGFINGEGDGCGILTDIPRALWEKKLQENGLDGKLAYDERFSVAHIFVPRKLDLTVAQMQEGIRALFAKFGVSILMEQENQVDSSVLGPNGRNDEPTFWQIAGLCEKQEVKVADHLFELHVAIEDQYTVHVATLSNVTAAYKVMGAASILPKYFNDTRDPLFAAQVTIGHNRYSTNTQSSFFRVQPFSLLGHNGEINTVKKLRIEADMVGVPLVDGGSDSQDMNRTIETFIHRSGMSLFEAMEVVFPPIHNEMKLFRPELQDLYVYYRQTWGHFAQGPAGIVSRYGNECIFSVDALGLRPVWMVESETSLYFSSEQGVITVGEMVADPKPIAPGEKIGVVLTPGEHIQVIPYYEVQNLVLKRAAARVGLDGLRKHLVQEVAVSEAAPSADIVPTDAVYSAFGWDRDGITMIESTAETGAEPIRSLGHDSPHAALAWERQNIPDFIKESVAVVTNPAIDRDREMEHFSTRVVVGPRPKVYGEPDARPRVEILYPVVLEGSNGIDSLAELKQPSLEQLVNLFGGPNGANVAVLSTTFPRGGSLEAALNELAAEAVRAVKNGAMLVVLDDSEAHQNDRLWMDPHLAVSKVDIALRAEKLGFGDNLRRQTTIVLRSAAIRNLHDIAVACGLGADVLSPYIMFATAASKDGAPAARKVFTALMKGLEKVISTIGTHELRGYTRFFSSIGLKPELADVLDIVNYLGSDKAGTGYAELEAEAEARYNDFSNPKAKAAKNFRFFQRMWKALGDAASGAAPYTDYRDKLREEEKKNAISIRHVAGFDFEKAHSEGRKPLEPSQVEIGIGGHSLPMLISSMSFGSQNETAFRAYAEAGERLNMVTMNGEGGEIKDMLGKYKRTRGAQVASGRFGVNVELANAVAFLEIKIGQGAKPGEGGHLPGSKVTAKIAAARNATIGSDLISPSNNHDIYSIEDLAQIISELKEASGRKAQIIVKIPVVPGVGTIAVGVAKAGADVITLSGFDGGTGAARIHSITHVGLPTEIGTKLAHLALIDAGLRHRVELWSDGGMKSGQDVVKMVMLGANRVGFGSIAMQSIGCTTCRGCHLDTCHVGIATQIDSMEEAEEKGLRRFVPRVYDLAVDGLVRIFSGIGEEIRETVAQLGFKNLQELVGRSDLLQQISHLERIDLSDLLRPAPLSFAAAQEAHAEVAAAVSSDIRIAAGAEGQEFFPDAVSFHAPVERTWSKVDAESRILGARYASHRVRDRFDGSYDSLPAVNITMTEGSVPGNGLAAFNARGVDITVHGGAEDGVGKMSLGGKVAILKAHSKHKQFINGSVGKSFGYGAQKGLFLIQGNADTRACIRFSGADVVFGGEITTPLRDDLGGLASRANLKGFAFEYMTNGRAVVLGDPGPWICAGMTGGVIYQRLVPEMGLDQAAIERRIAKGAKVKIEQIGVQSVKDLNELLGAYREELAKSGQMEAAATIDGLLANLQANFVRIAPVNLQADQSVATE
>NC_015690.1|WP_013914353.1|598307_599648_-|glutamate-1-semialdehyde-2,1-aminomutase
MSQHSSAGDARPRSSSLYQEALQHIVGGVNSPSRSFKAVGGGAPVFMKRGQGAYFWDEDGNRYIDYLAAYGPVILGHAHPHVTAAIVRAAENGTLYGTPTELEIRFARMLKEAIPSLDKVRFVNSGTEAVMTTIRVARAYTGRSKIIKFAGCYHGHSDLVLVAAGSGPSTLGIPDSAGIPVSIAHEVITVPFNDPKALDEALARWGDDVAAVMVEPIVGNFGMVMPQPGFLEALCGAARRNGSLVIYDEVITAFRFHYGAASTFAGLPAGTDYAAIEPDLTALGKIIGGGLPIGAYGGRAEIMSQVAPLGPAYQAGTMAGNPASISAGIACLEALSEPGTYERLDRLGAMLEEGLAAAAAQHGIPLTINRIRGALSTHFCSHPVTNYEQAQDTDGESFASFFCHMLAEGVCLAPSKYEAWFTTTAHTEADIAYTIEAANRAFARMK

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Crispr_ID: NC_015690_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015690_2

861338-861526

Orphan

Consensus_repeat	Method
ATAGCGAACCTCAGTTCCGCTATTT	CRISPRCasFinder

3 spacers

The CRISPR arrays of NC_015690_2

>merge|NC_015690|2|861338-861526|CRISPRCasFinder
ATAGCGGAACTCCGATGCTTTATTTGATTATTTCCCAACATTTCCCGAACAATAGCGGAACTCAGGTATCTTATTCGTCATTATCTCTACCTCAAGCGGCCTTGGCCATGAAAATAGCGAACCTCAGTTCCGCTATTTCCAAAATGGTCCTGCTTGAAAGGGAGATAGCGAACCTGAGTTCCGCTATTT

>NC_015690|2|1|861338-861526|CRISPRCasFinder
ATAGCGGAACTCCGATGCTTTATTT	GATTATTTCCCAACATTTCCCGAACA
ATAGCGGAACTCAGGTATCTTATTC	GTCATTATCTCTACCTCAAGCGGCCTTGGCCATGAAA
ATAGCGAACCTCAGTTCCGCTATTT	CCAAAATGGTCCTGCTTGAAAGGGAG
ATAGCGAACCTGAGTTCCGCTATTT

Protein	Signature genes	Signature genes Name	Protein_function
NC_015690.1\|WP_041616507.1\|876648_878793_+\|molybdopterin-oxidoreductase-family-protein	unknown	unknown	gnl\|CDD\|239155
NC_015690.1\|WP_013914589.1\|852872_854510_+\|alkaline-phosphatase-D-family-protein	unknown	unknown	gnl\|CDD\|226070
NC_015690.1\|WP_013914599.1\|865260_865911_+\|DUF1989-domain-containing-protein	unknown	unknown	gnl\|CDD\|132465
NC_015690.1\|WP_013914597.1\|862565_863933_-\|APC-family-permease	unknown	unknown	gnl\|CDD\|223605
NC_015690.1\|WP_013914587.1\|852494_852641_-\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013914605.1\|874249_876643_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224171
NC_015690.1\|WP_013914598.1\|864457_865174_+\|urea-carboxylase-associated-family-protein	unknown	unknown	gnl\|CDD\|163257
NC_015690.1\|WP_013914590.1\|854632_855424_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235546
NC_015690.1\|WP_143768184.1\|855752_856514_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NC_015690.1\|WP_013914584.1\|849429_850428_+\|aromatic-ring-hydroxylating-dioxygenase-subunit-alpha	unknown	unknown	gnl\|CDD\|226985
NC_015690.1\|WP_013914600.1\|865940_869573_+\|urea-carboxylase	unknown	unknown	gnl\|CDD\|274264
NC_015690.1\|WP_013914601.1\|869572_871387_+\|allophanate-hydrolase	unknown	unknown	gnl\|CDD\|236177
NC_015690.1\|WP_013914603.1\|871851_872397_+\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013914592.1\|856618_858064_-\|PLP-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|224089
NC_015690.1\|WP_013914595.1\|858982_861031_+\|molybdopterin-oxidoreductase-family-protein	unknown	unknown	gnl\|CDD\|239167
NC_015690.1\|WP_013914596.1\|861913_862420_-\|chemotaxis-protein	unknown	unknown	gnl\|CDD\|206779
NC_015690.1\|WP_013914593.1\|858189_858831_+\|LysE-family-transporter	unknown	unknown	gnl\|CDD\|224198
NC_015690.1\|WP_014368496.1\|872992_874174_+\|NarK/NasA-family-nitrate-transporter	unknown	unknown	gnl\|CDD\|225133
NC_015690.1\|WP_013914586.1\|851200_852289_+\|DUF418-domain-containing-protein	unknown	unknown	gnl\|CDD\|225193
NC_015690.1\|WP_013914585.1\|850626_851190_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102

Protein	Function_ID	Function_description	E-value
NC_015690.1\|WP_013914589.1\|852872_854510_+\|alkaline-phosphatase-D-family-protein	gnl\|CDD\|226070	COG3540, PhoD, Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism].	0
NC_015690.1\|WP_013914599.1\|865260_865911_+\|DUF1989-domain-containing-protein	gnl\|CDD\|132465	TIGR03424, urea_degr_1, urea carboxylase-associated protein 1. A number of bacteria degrade urea as a nitrogen source by the urea carboxylase/allophanate hydrolase pathway, which uses biotin and consumes ATP, rather than my means of the nickel-dependent enzyme urease. This model represents one of a pair of homologous, tandem uncharacterized genes found together with the urea carboxylase and allophanate hydrolase genes.	1.03599e-121
NC_015690.1\|WP_013914601.1\|869572_871387_+\|allophanate-hydrolase	gnl\|CDD\|236177	PRK08186, PRK08186, allophanate hydrolase; Provisional.	0
NC_015690.1\|WP_013914592.1\|856618_858064_-\|PLP-dependent-aminotransferase-family-protein	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	1.54425e-136
NC_015690.1\|WP_013914605.1\|874249_876643_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224171	COG1251, NirB, NAD(P)H-nitrite reductase [Energy production and conversion].	0
NC_015690.1\|WP_013914598.1\|864457_865174_+\|urea-carboxylase-associated-family-protein	gnl\|CDD\|163257	TIGR03425, urea_degr_2, urea carboxylase-associated protein 2. A number of bacteria degrade urea as a nitrogen source by the urea carboxylase/allophanate hydrolase pathway, which uses biotin and consumes ATP, rather than my means of the nickel-dependent enzyme urease. This model represents one of a pair of homologous, tandem uncharacterized genes found together with the urea carboxylase and allophanate hydrolase genes.	6.69346e-115
NC_015690.1\|WP_013914590.1\|854632_855424_+\|SDR-family-oxidoreductase	gnl\|CDD\|235546	PRK05653, fabG, 3-oxoacyl-ACP reductase FabG.	3.08143e-96
NC_015690.1\|WP_143768184.1\|855752_856514_+\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	4.2516e-09
NC_015690.1\|WP_013914597.1\|862565_863933_-\|APC-family-permease	gnl\|CDD\|223605	COG0531, PotE, Amino acid transporters [Amino acid transport and metabolism].	9.6919e-42
NC_015690.1\|WP_013914600.1\|865940_869573_+\|urea-carboxylase	gnl\|CDD\|274264	TIGR02712, Includes:_Allophanate_hydrolase, urea carboxylase. Members of this family are ATP-dependent urea carboxylase, including characterized members from Oleomonas sagaranensis (alpha class Proteobacterium) and yeasts such as Saccharomyces cerevisiae. The allophanate hydrolase domain of the yeast enzyme is not included in this model and is represented by an adjacent gene in Oleomonas sagaranensis. The fusion of urea carboxylase and allophanate hydrolase is designated urea amidolyase. The enzyme from Oleomonas sagaranensis was shown to be highly active on acetamide and formamide as well as urea. [Central intermediary metabolism, Nitrogen metabolism].	0
NC_015690.1\|WP_014368496.1\|872992_874174_+\|NarK/NasA-family-nitrate-transporter	gnl\|CDD\|225133	COG2223, NarK, Nitrate/nitrite transporter [Inorganic ion transport and metabolism].	2.42159e-94
NC_015690.1\|WP_041616507.1\|876648_878793_+\|molybdopterin-oxidoreductase-family-protein	gnl\|CDD\|239155	cd02754, MopB_Nitrate-R-NapA-like, Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored tetraheme cytochrome. Members of the MopB_Nitrate-R-NapA CD belong to the molybdopterin_binding (MopB) superfamily of proteins.	0
NC_015690.1\|WP_013914596.1\|861913_862420_-\|chemotaxis-protein	gnl\|CDD\|206779	cd11386, MCP_signal, Methyl-accepting chemotaxis protein (MCP), signaling domain. Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.	3.50821e-19
NC_015690.1\|WP_013914595.1\|858982_861031_+\|molybdopterin-oxidoreductase-family-protein	gnl\|CDD\|239167	cd02766, MopB_3, The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins.	0
NC_015690.1\|WP_013914593.1\|858189_858831_+\|LysE-family-transporter	gnl\|CDD\|224198	COG1279, COG1279, Lysine efflux permease [General function prediction only].	1.7783e-49
NC_015690.1\|WP_013914584.1\|849429_850428_+\|aromatic-ring-hydroxylating-dioxygenase-subunit-alpha	gnl\|CDD\|226985	COG4638, HcaE, Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only].	1.31625e-48
NC_015690.1\|WP_013914586.1\|851200_852289_+\|DUF418-domain-containing-protein	gnl\|CDD\|225193	COG2311, COG2311, Predicted membrane protein [Function unknown].	2.54493e-14
NC_015690.1\|WP_013914585.1\|850626_851190_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	1.32082e-17

>NC_015690.1|WP_013914595.1|858982_861031_+|molybdopterin-oxidoreductase-family-protein
MNSYTLQPDGVFPSVCSLDCPDQCGLLVHKKEGRIVKIEGDPSHPVTQGAICNKVRHMAHRIYDEKRLQYPLKRVGRKGEGRFERITWDEAIDTIVARWNKIIAEQGAEAILPYSFYGNMGRLGTEGMDRRFFHRLGASRLQYTICQAAGTEGYNYTMGGGFGIDPEDTVHAELIIMWGINAVSTNMHQVVLAEKARKRGAKIVVIDVHKNQTGRWADWFIPVRPGTDAALALGLMHILFAEGLTDEAFLERYTVGHAELREHVRSYDPDSVAEITGVPVEDLYRLARMYGGTKASFLRIGNGPQHHDNGGMCIRTIACLPALTGAWLYPGGGAIKGNGSYLEHNAQALQRPDLLPKQTRRINMNLLGSALLELDPPVASLFVYNSNPAVVAPHANKVREGLAREDLFTVVHELFLTETAAYADLVLPATSAFENTDFYRSYWHHYVQIQEPVIEAYGESKSNVEVFRLLAAAMGFEDEALRDTEADMIRQALDYPRNEVLEGMTYEKLAEQQFLKGKVKPLFPGRLHTPSGKIELYSKTMERRGFPPLPTYIPLPVEDEGDLPFLFIPAPNHNFLNSTFAHNDKHVRMEREPKLHINEADAAALGIANGDRVRVWNARGECELTAAVGTDVLPGVAVSQGLWADGKDGKALVNALTPDRVADMGGGAVFFSGRVRIEKCAG
>NC_015690.1|WP_013914593.1|858189_858831_+|LysE-family-transporter
MAFVHGVLLAFGLILPLGVQNVFIFNQGAVQPRFVRALPAVLTAALCDMLLILAAVLGVSLLILTVSWIKTVLVLAGILFLLYMGLVTWRTPAAAAPAGTEGDPAQPEGDGAGSAAVMGPRRQMLFAASVSLFNPHAILDTIGVIGTSSLRYAGADKVLFAAAAIGVSLVWFLFLAGAGRLAGRLHSPLRLYLNKASALIMWGSALYLGWSFS
>NC_015690.1|WP_013914592.1|856618_858064_-|PLP-dependent-aminotransferase-family-protein
MKGSLHWKPDPTSKIPVFKQIAGHLKERILSGEWTAGSRIPVQRQLAGQFGVNRSTIVTALEELKAEGLLEGITGSGTRVRSTPAAGPDSSRSLDWDAYIRRGIHMPNLPAVQAINRAEADPAVVRLGTGELAPELIPSGMLQRMLGRLARQPLPGGYEEPLGSPALRSEVSRHLAGYGITASPSSILIVSGALQALHLISMGILRQGATVFLENPSYLHSIHAMPAVHTRMAGIPMDGEGLRVDRLSEHAEDMNGAVLYTIPSFHNPSGIVMSGPRRAEVLRFCTEHGLPLLEDDVYRDLWLDAPPPPPIKSMDAGGITLYIGSLSKTLSPGLRVGWVVGPQPVVERLADIKMQTDYGTSSISQALARECLAGGLYEKHLHRVREQLRVRRSAMLESLEQYCRGLLEWSTPQGGFYIWAKVPARSGAKPLFQRMLKKGFLLNPGYVYGPSCGAYLRLSYAYAPVPDMQRGIRELGALLRQ
>NC_015690.1|WP_143768184.1|855752_856514_+|CPBP-family-intramembrane-metalloprotease
MACLFVGAVIGVQVLPLGYTAAGAAGLLLLSLFRPHASYRGAAAATAAYMAGYVIYTCLVPLFHALPGDREAVISLSRLSLIGFLVPFYFANRMDPPRVNYLKRGSFRETIYFPFIFSGFLRDPIWRFLLIFAAVTLTAFVWAMDWKQENLGRMLLYALLFAVINAPLEEVLWRGYVLSRFTDRLGETRGLLAMALGFGFYHYSLGFPWSICALFSFFGLLMGGVAVRSRGLLPVILLHFWMNVLFVLGGIVF
>NC_015690.1|WP_013914590.1|854632_855424_+|SDR-family-oxidoreductase
MSGQRVKGRAAVVTGGASGIGRASALRLAEHGAKVCLLDRSVEEAEEVRQAIERAGGEAMVVECDVSRPEQIQAGIEQAAARWGRLDIVFANAGVNGTVAPIETMETGDWDETIAINLRGTFAAVKYAIPHLKEGGGSIVITSSINGNRVFSGFGFGAYSTTKAGQVAFMKMAALELAQFKIRVNAVCPGAIETNIGRNTHPVPELEEIRIPVEFPEGGQPLEGGPGRPEQVADLVLFLASDESSHITGTAVYIDGAESLLHG
>NC_015690.1|WP_013914589.1|852872_854510_+|alkaline-phosphatase-D-family-protein
MEQDKLGLLQQMMEKLGASSMDRRGFLRATGKVAAVSFGLTLASALQSPPKIGAEAFFKSYPFTLGIASGDPLPDGVVLWTRLAPDPLNGGGMPSHDVPVRWEVALDKEFRRIVKHGVEFARTALAHSVHVEVEGLEPNQVYYYRFHAGHVESPVGRTKTLPPYGSAVAGMTFAFASCQNWQDGYYTAYKHMSKENLDLVFHLGDYIYEGGVGTDKVRYHNSPEIVTLEDYRNRYALYKSDADLRAAHEAFPWVVTTDDHEVENNYAGPIPEKDQPVEPFVQRRAAAYQAYYEHMPLRRSSLPYGTEMQLYRRVTYGNLAEFSVLDTRQYRDDQANGDGSKEPNEASMDPNRTLMGAAQERWLLEGLGASAARWNVIPQQVFFAKRDFKQGDAELVSMDAWDGYSANRDRIVNFIKERGVRNVVVLTGDVHANYANEIKADYHDPASPVIGVEFVGTSISSGGDGADTAANTATILAENPHIRFHNTQRGYVRCTLTPDRFQADYLVLPYVSRPDAPIETRVSFEVEDGRPGLKKIYDSALVVTG
>NC_015690.1|WP_013914587.1|852494_852641_-|hypothetical-protein
MITSNSNSEAFFTSIDDIINFYSSQHQSADSKETDLDSHTEAGANRPD
>NC_015690.1|WP_013914586.1|851200_852289_+|DUF418-domain-containing-protein
MVKDEAKGAAERLTGLDLARSLAVFGMILVNYRIAMGAEAGGPPWLAAAAGLLEGRSSAVFVMLAGIGLSLMTRRARQGEAGELRRSRTVIRKRALYLLLLGIGLLLAGWSADILHYYALYLFLGSFLIRAPSGALLVWTAGLLVCAQGQLLLLDYRTGWDPAFHQYLDFWTPEGFLRNLWFNGYHPMLPWFAFFVFGMWLGRLSLRDEAVRRRGLLVSLGVGFLSEATAFAARSASIPYLDEEGAAYLFGTKPMPPGLFYMLSAGGTAAAVILLCLYAADRLQESALAARLIPAGQMALTHYVLHVIAGLGLLELLGALENGSLPFALLYGTGYYAAALLLSGRWLNRFGRGPFEALMRRL
>NC_015690.1|WP_013914585.1|850626_851190_+|TetR/AcrR-family-transcriptional-regulator
MSTQELILESAYRLFARHGFEKTSLSMIAKEVGISKPAVYYYFPSKEALFGALLEAVCSEIRFGKYFPLASFTVDNYKEQLTGCGLRMIGEQRSDPHYSLLMKEFMIQSTRDESILSAMMAVIQAYVEGFHELLRHGADLGIVQGEDLRAKAEQLTMIVDGIDNYMGLGVAFDYERLWSYTVEQVLR
>NC_015690.1|WP_013914584.1|849429_850428_+|aromatic-ring-hydroxylating-dioxygenase-subunit-alpha
MNTAEMLRDTVLENEWHPVCIAGELNDKPLSVTVLGERVAVFRTKRGVHALRDLCVHRGAMLSKGWVEGETLVCPYHGWKYEGNGACVCIPAQSKEDKIPARARAEQYRCMEKYGLVWVCIGEPSAPLPDFEEFENPGYRPLPCGPYQVKAAGTRVIENFTDFAHLMFVHGGLLGHPDYAELPDFKVYKEKDRVYTGDVPIFQPVAHSGSEAKEGTTYVYVKEVFRPLAARLSKRDAATGQTLWILLTVLPVTEKECTVYMAVSRNYGFDVDDRQFIEFQNTVFEQDAWIIETQKPELLPLDLQAELNHKADVLSVAYRRWLIELGVKIGTA
>NC_015690.1|WP_013914596.1|861913_862420_-|chemotaxis-protein
MTNKNELMTIVGQMADTLAQATERLSSVAQDSDSLARISQQLLAQSQTSNEDAKKTDEVLAFIRHVAGQTNLLGLNASIESARAGEMGRGFAVVASEIRKLSLDTISSAEKIQDILSNIRQTTDSISSTVREIHTIGQRQVTSAAGIEASMREIEAMSRQLSTFVSRL
>NC_015690.1|WP_013914597.1|862565_863933_-|APC-family-permease
MMNQEVTLKKSLTLFGVVYLGLAWMTPMIYFSVYGIAYDTSQGMLTQAYLVAFLAIFFTASSYGIMARTFPASGSAYTYVKKSIHPYPGFLVGWALLLDYLFSPLIACLTFGIYLNAQFPSVPAGVWIVLLNIVLAVIASLGVNFSAQLSKVFVWIQMAFIGVFCLFLLKNLSGAAVHPLQPLLQTDVPPSVIFAGASIICFCFLGFDSVTTMSEETHHAQTTIPRAIRIIILMAGTLYLAPSYLTQLAFPQAMTFENADSAGFEVVKLVGGAALSSLFITVLVLAIFTQGLSSLTTVSRLLFVMGRDTTLPRRFFGSLHPRFQTPVANIVLVSLVSLLALVISLETAVKFVSFGALTAFIFVNLSVIAQKYVREKLRSPLETCRYLLFPLIGAGFIGWLLSLLDASALLMGGAWVAFGAVYHYLRGPSLHRSEDKNTPAAAHPSPTRIGADRLG
>NC_015690.1|WP_013914598.1|864457_865174_+|urea-carboxylase-associated-family-protein
MNGVWQITIPAGGKWSGVVGRGRLVRFTALEEGANLTVLLYNAKDPSERYNMPDTLKAQHTSHLTRGHVLMSDNGRVLASLTEDTLGWHDPIGGYSTRAGTDARYGLTNYQELRNNWLRSGEENLTVELVRAGLGRRDLVPPVNLFSKISCDEQGDMHFVPRHCPKGAQVTLRTEMDILVLLSNTPNPLDPSPSYPSVPVLVEVLEAEPVNEDDYCLNFRPENTRAFENTWAYYALLG
>NC_015690.1|WP_013914599.1|865260_865911_+|DUF1989-domain-containing-protein
MAVFNRLESPRKIEDAVYDVIVPAGDGWMKELEPGQVLRIVDLEGNQAADTLFYDAENPEDHYSAIATMTGQGNIYLTAGSVLRTESGKALLTIVADTCGRHDTLGGACSAQSNTVRYSHDTLPMHNCRDTFLLQMAKFDKGYLKRDLAPNINFFMNVPVTPEGGLKFDDGVSSPGAYVEMQAHGRTTALVSNCPQLNNPCNAYNPTPIRILIWDN
>NC_015690.1|WP_013914600.1|865940_869573_+|urea-carboxylase
MFSKVLIANRGAIAVRIERTLRRLGIASVAVYTQADQDSLHVDGADEAVYIGEGAAKDSYLNTELILETAIRTGAQAIHPGYGFLSENADFARACRERGIAFIGPTPEQMEAFGLKHSAREIAGRAGVPMLPGTELITELGEALVQAAAIGYPVILKSTAGGGGIGMRVCADEEALRSAYDGVRHLAETNFKNGGLFLEKYIAKARHVEVQIFGNAFGEVVTLGERDCSIQRRNQKVVEESPAPNFPEEVRAAMLGAAGRLAAEVGYRSAGTVEFLYDPETCEFYFLEVNTRLQVEHGVTEEVLGIDLVEWMVREAADELTGLQALVPEPQGHSIQARIYAEDCLHDFRPSAGQLDRAVFPEGARVETWVRDGLTVTTLYDPMLAKIIVHAATREEALAKLAAALEEARLYGLTTNLQYLQALLQEPDCREGRVFTRMLNGFAPEERAVEVLDGGVQTTVQDYPGRTGHWDVGVPPCGPMDPLSFRIGNKLLGNPDDASGLELTLRGGSYTFRSEVWFCITGADMEAKLDDKHVPRYQAVCAGRGQVLSFGEAKEGMRAYLLVAGGFDMPKVLGSSATFTLGGFGGHGGRALRAGDVLGVNASAVPAVPEGLPPVQQPQLSREWTIGVVPGPHCTEEFLRPEYLPQLTSTSWEVHFNSSRTGVRLIGPAPLWTREDGGEAGLHPSNIHDNAYAVGTLDLTGDMPILLGPDGPSLGGFVCPVTTASAEFWKIGQLHAGDKVRFRLLTLEEAEALREAQEEDLASIGAAERIGRAPAVLPEPVEFAPSYPVLIRQEEGRIFPITIRCSGDRNLLVEYGALELDLLLRFQVHALMQAIRDDGGIPVLDLTPGIRSLQVHIDPSRMTVREAARRILAIDAALPPLESIRVPSRIVRLPLSWDDPATRLAIERYQQNVRPDAPWCPSNLEFIRRVNGLDSIEEVQRIVFDANYLVLGLGDVYLGAPVATPTDPRHRLVTTKYNPARTWTPENAVGIGGAYMCVYGMEGPGGYQFVGRTIQMWNKLRETESFKPGHPWLLRFFDQIRFYPVEADELLRLREDFLRGRYEADITETTFDLGEYLTFLDSIKESADVFRAGQQAAFQAERESWKRLGLAEYVSEHEAAEPQEEEVLPPGAVGVRCMMPGSVWKVLVEPGQYVKKGDVIIIEESMKMEFPQQAPCDGYVLSVYVSPGDEVHAGQLIAGLQTELESEGVA
>NC_015690.1|WP_013914601.1|869572_871387_+|allophanate-hydrolase
MAHLEIPEVLTAAWLREKYRARELTPESVIAEVLKRSAADALMNIWITPPALETLRPYLERLAELDPELYPLWGIPFAVKDNIDVAGVPTTAACAEFAYTPDAHAAVVERLVAAGAIPLGKTNLDQFATGLVGTRSPYGETRNALRPELISGGSSSGSAVAVARGQAVFALGTDTAGSGRVPAALHGLVGWKPSLGAWPTLGVVPACASLDCVTVFAHSLDDALLVDRAVRGVHDADPWSRELPDPLPKLPARLLLPKGELGFYGPFAEGYRAAWGAARERALSLGLVVEEVETELFAQAAAILYEGPWVAERWADLGGFVESHPGAAFPVTEKILRTGASAEYDAASVFRAMHRLQSYKLEARRLLQDAVLLMPTAGGTWTRDAVREDPVGANRDMGRYTNHCNLLDLCAIAVPAGEAEERTPFGVTLFALAENEGLIGAAAEAFLAGSAGGERDAARDAASSAAGTAASTGEPRPGTTLVAVCGLHMRGFPLEKQMLECGAVFIREALSAPKYQLVKLPTVPAKPGMIKRPAGGAAIQLEVWEMPLVSFGSFTAGIPAPLGIGKVELEDGTEVPGFVCEAYAAADAEDITASGGWRFVTAAG
>NC_015690.1|WP_013914603.1|871851_872397_+|hypothetical-protein
MNSTPQDRAVLEEQARRTLALNPDVVFGEVMTMEIAPEDAPLWLRFTSEWGGALYLLDETNAKRHERGMIGDEAFEYNRRTYRLGLITLSGLYDRLKGWQEGEGKVRPFAFAMNSLDCYFVPAYLADYSRVHEAGKEVCDAFIAEVMHRLDGGDEVRKEFEALDVLVGEYVRGIHLYARGQ
>NC_015690.1|WP_014368496.1|872992_874174_+|NarK/NasA-family-nitrate-transporter
MKQRRPALALGLSTLAMASSFMVWNVFSPIAGSLREAFGLTALQQSVLVAAPVLLGSVMRFPMGIFTDRFGGRRVFTSLLLFLVLPLLLTPFVSSYATLLLSAFLLGMAGTAFSVSMTYVSKWYPPQKQGLVLGLAGLGNLGVAMSSFLVPLVYRQYGLPGVFYGLAGLILVTAALFRWGAGELPLPEKKQTVQESLKVLRFRSTWLLSLFYFLTFGGFVAFSVYLPTLLKELFGMAAADAGLATAGFVAAATFIRPLGGYLADRIGSRQVLLGVFIGIAGAALLLAFSLKDFRIFAAGCLLAGLCFGLGNGAVFKMVPEIAPGHTGAVTGVVGAAGGVGGFFPPIVLGLLRDSGGTYMPGFVLLALFACICLWLNGAGRRMKEREPAKVSAA
>NC_015690.1|WP_013914605.1|874249_876643_+|NAD(P)/FAD-dependent-oxidoreductase
MDQREAMKMSKPRIVLVGGGMAGVRCLEEILKLAPGRFDMTVIGSEIHPNYNRILLSKVLQGDTRVEDITLNSREWFEANGIRLITGETVVQADTKRRRILTDKGRTAEYDYLILATGSLPFMLPIPGAAKQGVTAFRDIEDCRRMIEAAKTCRKAVVIGGGLLGLEAARGLLNLGMEVDVVHLNPYLMERQLDPTASRMLKKELEGQGMRFLLEKSSQEILGSERVTGLKFTDGTQTAADLIVMAVGVRPNVGLAKDSGIETGRGILVNDYMETGTPGVYAVGECAEHRGIVYGLVAPLYEQGKVLAQRICGTASEEEGYQGSILATQLKVSGVEVFSAGDIADTDETESLQHYDGIRGVYRKIWVRGRRITGAVLYGDASEGTKLLGYIKQGADVSVLEEKPAGAAEGAQDAYLCAMADSETVCSCNGVTKGSIVRAVREQGLETFEEVRSCTKASSSCGGCKPLVSALLAYTLANAEGPGAEAESVCGCTDLSREALREAVTAQTWTSAAEAMQALGWRTPDGCADCRPAVRYYAGLGQPAAAEVPAAGRLADGTYAVIPRLYGGQAGAKELRRIAEAMERHGIPRAKLSGDGQLQLLGVPAAKVREVASDLKLPTVVSASGLAVGSVTSCTGLGYDPSAMQDSAGMAAGLEEAVEGLQLPARVRIAVSGSPLHRAETLTRDLGLAGTPDGWEIYVGGSAQAQVKGGQLLCTESSGERAVEIAAAFLQWYREEAYYGETAGEWVDRVGLLPLREGLFHPERRGELVQRLLEERLRAAAAEARHSNKRNEAAVGR
>NC_015690.1|WP_041616507.1|876648_878793_+|molybdopterin-oxidoreductase-family-protein
MKPIGPVLEAGRSTSPLVMDTQCPFCSVQCKMRITGEFDGKRMNYTVEGQPNAASEGRLCVKGMNAYQHALSSERILHPMRRLPDGTFERITWKEAYQEIARRFYEIQRGFGSDAVGVYGGGSLTNESAYLLGKFARVALRTKYIDYNGRFCMSAAASAGNKALGMDRGLTNPLSDIPLAKCIILAGTNIAECQPTLMPYFTRAKEQGAFIIAIDPRETATTQMADLHLQVKPGTDAALANGLLKVILDEGLTDPAFVEGRTRGFTELAAHLEAMDLGVIAGMTGVSAELIRRAASAYGRASTGMVFTARGVEQQTDGYMAVRNFLNLVLVTGKIGRPGCGYGAVTGQGNGQGGREHGQKADQLPGYRLIENEADRAYVAGIWGIDPSELPGKGVSAYEMMEKVHDREIRALFLMGSNPIVSNPNAVFVEEGLKKLDFLVVADMLMSETAKMADILLPASAYLENEGTLTNLEGRVLLREAAREVPGEVQHDWQILCGVASVLGRGRYFGFRSAEEIFDELRHASRGGAADYYGITYDRLRREGGVYWPCPSPDEANSGRLFEETFAHGDGLAELLPVDSRFPVETACSEYPLYLTTGRVLSHYLTGVQTRRSPSLAAREIETFAELHPRTARRFKIGEGALIVLETRRGTMTARTRLHTGIREDTVFVPMHWGDGQYVNRLTHPALDPVCRMPGFKVCAVRVEPLVTARADDL

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Crispr_ID: NC_015690_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015690_4

1005040-1005185

Orphan

Consensus_repeat	Method
TCGGTGGCGCCGGAACACGGAAAATCCGTGT	PILER-CR

2 spacers

The CRISPR arrays of NC_015690_4

>merge|NC_015690|4|1005040-1005185|PILER-CR
TCGGTGGCTCCGGAACACGGATAATCCGTGTAAGATGAGCGGGAGTGCGCCCCGAGGAGTGCAGCAGCGACGGGTTAACACGGAAAATCCGTGTTGGGTAGTGAGCAGCCGGACCTCGGTGGCGCTGGAACACGGAAAAACCGTGA

>NC_015690|4|3|1005040-1005185|PILER-CR
TCGGTGGCTCCGGAACACGGATAATCCGTGT	AAGATGAGCGGGAGTGCGCCCCGAGGAGTGCAGCAGCGACGGGTT
AACACGGAAAATCCGTGTTGGGTAGTGAGCA	GCCGGACCTCGGTGGCGCTGG
AACACGGAAAAACCGTGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_015690.1\|WP_013914727.1\|1011196_1011580_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319898
NC_015690.1\|WP_013914729.1\|1012538_1013210_+\|NAD(P)H-binding-protein	unknown	unknown	gnl\|CDD\|187560
NC_015690.1\|WP_013914730.1\|1013333_1013648_-\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013914721.1\|1006979_1007537_+\|spore-protease-YyaC	unknown	unknown	gnl\|CDD\|115518
NC_015690.1\|WP_013914710.1\|998523_999318_+\|thymidylate-synthase	unknown	unknown	gnl\|CDD\|234984
NC_015690.1\|WP_013914722.1\|1007536_1009360_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_015690.1\|WP_013914716.1\|1003839_1004340_+\|copper-amine-oxidase-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|377924
NC_015690.1\|WP_013914708.1\|996386_997709_+\|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|223936
NC_015690.1\|WP_013914728.1\|1011727_1012351_+\|DUF3298-and-DUF4163-domain-containing-protein	unknown	unknown	gnl\|CDD\|378702
NC_015690.1\|WP_013914731.1\|1013720_1014839_-\|GerAB/ArcD/ProY-family-transporter	unknown	unknown	gnl\|CDD\|281794
NC_015690.1\|WP_013914711.1\|999380_999890_+\|dihydrofolate-reductase	unknown	unknown	gnl\|CDD\|365932
NC_015690.1\|WP_013914713.1\|1000420_1001272_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NC_015690.1\|WP_013914714.1\|1001437_1002829_+\|glycoside-hydrolase-family-4	unknown	unknown	gnl\|CDD\|133433
NC_015690.1\|WP_013914720.1\|1005558_1006803_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|213815
NC_015690.1\|WP_013914715.1\|1003076_1003607_+\|DUF1572-family-protein	unknown	unknown	gnl\|CDD\|311521
NC_015690.1\|WP_013914726.1\|1010210_1010978_-\|TSUP-family-transporter	unknown	unknown	gnl\|CDD\|182593
NC_015690.1\|WP_013914724.1\|1009660_1009951_+\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013914709.1\|997730_998375_+\|LPS-biosynthesis-protein	unknown	unknown	gnl\|CDD\|226453
NC_015690.1\|WP_187296720.1\|1004429_1004603_-\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013914712.1\|999984_1000302_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_015690.1\|WP_013914727.1\|1011196_1011580_+\|VOC-family-protein	gnl\|CDD\|319898	cd06587, VOC, vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). Type I extradiol dioxygenases catalyze the incorporation of both atoms of molecular oxygen into aromatic substrates, which results in the cleavage of aromatic rings. They are key enzymes in the degradation of aromatic compounds. Type I extradiol dioxygenases include class I and class II enzymes. Class I and II enzymes show sequence similarity; the two-domain class II enzymes evolved from a class I enzyme through gene duplication. Glyoxylase I catalyzes the glutathione-dependent inactivation of toxic methylglyoxal, requiring zinc or nickel ions for activity. The antibiotic resistance proteins in this family use a variety of mechanisms to block the function of antibiotics. Bleomycin resistance protein (BLMA) sequesters bleomycin's activity by directly binding to it. Whereas, three types of fosfomycin resistance proteins employ different mechanisms to render fosfomycin inactive by modifying the fosfomycin molecule. Although the proteins in this superfamily are functionally distinct, their structures are similar. The difference among the three dimensional structures of the three types of proteins in this superfamily is interesting from an evolutionary perspective. Both glyoxalase I and BLMA show domain swapping between subunits. However, there is no domain swapping for type 1 extradiol dioxygenases.	7.15408e-20
NC_015690.1\|WP_013914729.1\|1012538_1013210_+\|NAD(P)H-binding-protein	gnl\|CDD\|187560	cd05250, CC3_like_SDR_a, CC3(TIP30)-like, atypical (a) SDRs. Atypical SDRs in this subgroup include CC3 (also known as TIP30) which is implicated in tumor suppression. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine rich NAD(P)-binding motif that resembles the extended SDRs, and have an active site triad of the SDRs (YXXXK and upstream Ser), although the upstream Asn of the usual SDR active site is substituted with Asp. For CC3, the Tyr of the triad is displaced compared to the usual SDRs and the protein is monomeric, both these observations suggest that the usual SDR catalytic activity is not present. NADP appears to serve an important role as a ligand, and may be important in the interaction with other macromolecules. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	3.89311e-69
NC_015690.1\|WP_013914722.1\|1007536_1009360_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	1.86299e-178
NC_015690.1\|WP_013914710.1\|998523_999318_+\|thymidylate-synthase	gnl\|CDD\|234984	PRK01827, thyA, thymidylate synthase; Reviewed.	0
NC_015690.1\|WP_013914716.1\|1003839_1004340_+\|copper-amine-oxidase-N-terminal-domain-containing-protein	gnl\|CDD\|377924	pfam07833, Cu_amine_oxidN1, Copper amine oxidase N-terminal domain. Copper amine oxidases catalyze the oxidative deamination of primary amines to the corresponding aldehydes, while reducing molecular oxygen to hydrogen peroxide. These enzymes are dimers of identical subunits, each comprising four domains. The N-terminal domain, which is absent in some amine oxidases, consists of a five-stranded antiparallel beta sheet twisted around an alpha helix. The D1 domains from the two subunits comprise the 'stalk' of the mushroom-shaped dimer, and interact with each other but do not pack tightly against each other.	1.04985e-23
NC_015690.1\|WP_013914708.1\|996386_997709_+\|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	gnl\|CDD\|223936	COG1004, Ugd, Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane].	0
NC_015690.1\|WP_013914728.1\|1011727_1012351_+\|DUF3298-and-DUF4163-domain-containing-protein	gnl\|CDD\|378702	pfam11738, DUF3298, Protein of unknown function (DUF3298). This family of bacterial protein C-terminal regions is highly conserved but the function is not known. Several members are annotated as being endo-1,4-beta-xylanase-like, but this could not be confirmed, and the structure can be defined as a heat-shock cognate 70kd protein 44kd ATPase.	1.23315e-15
NC_015690.1\|WP_013914731.1\|1013720_1014839_-\|GerAB/ArcD/ProY-family-transporter	gnl\|CDD\|281794	pfam03845, Spore_permease, Spore germination protein.	3.09674e-48
NC_015690.1\|WP_013914711.1\|999380_999890_+\|dihydrofolate-reductase	gnl\|CDD\|365932	pfam00186, DHFR_1, Dihydrofolate reductase.	2.26785e-83
NC_015690.1\|WP_013914714.1\|1001437_1002829_+\|glycoside-hydrolase-family-4	gnl\|CDD\|133433	cd05297, GH4_alpha_glucosidase_galactosidase, Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases. Glucosidases cleave glycosidic bonds to release glucose from oligosaccharides. Alpha-glucosidases and alpha-galactosidases release alpha-D-glucose and alpha-D-galactose, respectively, via the hydrolysis of alpha-glycopyranoside bonds. Some bacteria simultaneously translocate and phosphorylate disaccharides via the phosphoenolpyruvate-dependent phosphotransferase system (PEP-PTS). After translocation, these phospho-disaccharides may be hydrolyzed by the GH4 glycoside hydrolases such as the alpha-glucosidases. Other organsisms (such as archaea and Thermotoga maritima) lack the PEP-PTS system, but have several enzymes normally associated with the PEP-PTS operon. Alpha-glucosidases and alpha-galactosidases are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.	8.90846e-96
NC_015690.1\|WP_013914720.1\|1005558_1006803_-\|glycosyltransferase	gnl\|CDD\|213815	TIGR03469, HpnB, hopene-associated glycosyltransferase HpnB. This family of genes include a glycosyl transferase, group 2 domain (pfam00535) which are responsible, generally for the transfer of nucleotide-diphosphate sugars to substrates such as polysaccharides and lipids. The genes of this family are often found in the same genetic locus with squalene-hopene cyclase genes, and are never associated with genes for the metabolism of phytoene. Indeed, the members of this family appear to never be found in a genome lacking squalene-hopene cyclase (SHC), although not all genomes encoding SHC have this glycosyl transferase. In the organism Zymomonas mobilis the linkage of this gene to hopanoid biosynthesis has been noted and the gene named HpnB. Hopanoids are known to feature polar glycosyl head groups in many organisms.	1.51989e-30
NC_015690.1\|WP_013914715.1\|1003076_1003607_+\|DUF1572-family-protein	gnl\|CDD\|311521	pfam07609, DUF1572, Protein of unknown function (DUF1572). These proteins, from several diverse bacteria, share a short conserved sequence towards their N termini.	1.20524e-85
NC_015690.1\|WP_013914726.1\|1010210_1010978_-\|TSUP-family-transporter	gnl\|CDD\|182593	PRK10621, PRK10621, hypothetical protein; Provisional.	1.79122e-40
NC_015690.1\|WP_013914709.1\|997730_998375_+\|LPS-biosynthesis-protein	gnl\|CDD\|226453	COG3944, COG3944, Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane].	9.79244e-37
NC_015690.1\|WP_013914713.1\|1000420_1001272_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	1.3079e-25
NC_015690.1\|WP_013914721.1\|1006979_1007537_+\|spore-protease-YyaC	gnl\|CDD\|115518	pfam06866, DUF1256, Protein of unknown function (DUF1256). This family consists of several uncharacterized bacterial proteins which seem to be specific to the orders Clostridia and Bacillales. Family members are typically around 180 residues in length. The function of this family is unknown. These proteins are related to peptidase family M63 and so may be peptidases.	5.47611e-51

>NC_015690.1|WP_187296720.1|1004429_1004603_-|hypothetical-protein
MLENRGGNASRLALLSLPQTKKPGIGLPGSASSGKGPALDLAAARFAEVASGWTAAD
>NC_015690.1|WP_013914716.1|1003839_1004340_+|copper-amine-oxidase-N-terminal-domain-containing-protein
MKRKMLGIWAGLLLFAAPVHAREEAPVVRVFVDGEQVIFEHPPILEQGTTLVPFRAISEKLGFEVAYRVENGEQSVTAVKGGETVTMYIGNRIANSAEGRVLLEQAPRIEHDLAYVPLRFLAEAMHVEVEWDGEQTAVRLHTQAPADGGAPPEEKAADPEPEAAGA
>NC_015690.1|WP_013914715.1|1003076_1003607_+|DUF1572-family-protein
MGEAQELGKVMLEESIQAFRSMKALGDRTLAQLEDVQFGEALDPESNSMEVLIRHMHGNMVSRWTDFLTTDGEKPDRDRDGEFEGAGAGREELLALWEAGWAVVFGTLESLQPADLLRTVTIRGEAHTVVKAIQRQVSHYGYHVGQMVFLGKHLRSESWQTLSIARGQSRAFRPGT
>NC_015690.1|WP_013914714.1|1001437_1002829_+|glycoside-hydrolase-family-4
MEETGISKPKVVVIGAGSLFFGRQSIWQMVQSQYLNQGTLALVDTDEERLSKMVTLAKMVAKENGVPLQVEGSTNRREVLQGADFVVLSFAKDSVKYRGIDCEVSLQYGIRMCSGDTIGPGGIFRAMRELPVIMECAKDIEEICPDAWVINYINPSTVHGIALSRYAPKLKSFALCDSHHMPHKKAHYAIRAGIIQHPSEFTEEIDRRFDLRIAGVNHFTWLLKAEYDGKDVMALIAEALRRSAGTENDGGDKGAKALHNDAITYELYDIFGSIPTCTAHTKEYVRYWQGLGKTEDAIPPLSIWETEDRYKRHEEMWRQVDDFISGPIPVADYMKIMGPDHATDIIESMVGNLGKRFFINTLNNGAVTNMNDDAFLELLSEVSLSDGIKPLPVGDMPRGIRGMQELVLDTHELTAEAVVERSFTKLRRAFMTDPLVNSIHDADLIIKELLEREKDIIPSYWYE
>NC_015690.1|WP_013914713.1|1000420_1001272_-|AraC-family-transcriptional-regulator
MNSTMPVMDIFNELSEFITLRMKSCKELTHDRDWHEHKAHSDYDLWFIQSGTVQIHIGETEHTANPGDVVFFYPGVPYRAASTDKGCRFIYAHFDFGMGTQQRILNDFRLSGIITRELIRDEAILFDNSFRQVERFGGTSGNRLHLKACMTALIAKIIELYGKGHYHGTFPKERMRGHSQGKLDLLQPVFQYIHNHLHQSIRMSELASLVGISEKYFISYFKKALGLTPGQYIYQIKMNRARDYLYEKKYTVHQIAGFLGYPDPFTFSKAFKKYYDVPPSKFV
>NC_015690.1|WP_013914712.1|999984_1000302_+|hypothetical-protein
MTEVNQHQMPNRHVIDNVEKAIQVAKDAEMAVRHAQLESNPQKLRTALAQLETAQHALGNAQAQLNSRDREHHGQEFVQVQNELTQSEQSLDITSQNTELPKQVR
>NC_015690.1|WP_013914711.1|999380_999890_+|dihydrofolate-reductase
MTVSYMFAMDEARGLGYQNRMPWYLPADFAYFKQTTLEHTVLMGRKTFDSLGGKSLPRRRNVILTRDKSFEAPGCETVTSPEDAVKPYRPGGEQADEELFVIGGAEIFSLLMPYADRMYITEIHHTFEVDTYFPELDRTEWKEVSRTKGPKDERNPYDYEFVIYERAAN
>NC_015690.1|WP_013914710.1|998523_999318_+|thymidylate-synthase
MKAYLELLEDILEHGVSKEDRTGTGTLSVFGRQLRFNLAEGFPLLTTKKMHIKSILHELLWFLSGDTNINYLKENGVTIWDEWADENGDLGPVYGSQWRSWPAPDGRSIDQITAVVEALKKNPDSRRHLVSAWNPAEVDEMALPPCHYAFQFYVAGGKLSCMFQMRSVDTFLGLPFNIASYAFLTHMVAQQCDLEVGELIWTGGDVHIYSNHLEQVKLQLTREPYPQPQLVIKRKPDSILGYRYEDFEITGYQSHPAIKAPIAV
>NC_015690.1|WP_013914709.1|997730_998375_+|LPS-biosynthesis-protein
MELSELISIILRRIWILLIAVLVCVGAAAYVSYFHMEKEYEASASMYVLKSNKTPSNNLYQELLAGSSLVKDYKELIKSKTVLKQVKDQLERSHTWAAQMTVEQLSQKLEISNKNDTHILVAAAKDTSPERAAVIANQVAVVFIEYSRQITVDESVQLIDAAEAADAPSQPKPLINMAVAAVVGVLVGLLAIFLQVQSQRSTTARRGKKPLEFS
>NC_015690.1|WP_013914708.1|996386_997709_+|UDP-glucose/GDP-mannose-dehydrogenase-family-protein
MQKIAVVGTGYVGLVTGTCLSDFGLETICVDIDETKIKRLKEGHIPIYEPGLEEMVTRNIQYRRLEFTTDIQSAVEQAEVIFIAVGTPAREDGSADLKYVLTVAEQIARSMNGYKVIVNKSTVPVGTGQKVKEVVQQVLDETGKSFEFDVVSNPEFLREGNALHDFTHPDKVVVGTESQRAKDIMKQVYRVLYLNETPFIFTNIETAEMIKYANNAFLAVKISFINEIANLCEKVGANVQQLAQAIGKDGRIGSKFLHAGPGYGGSCFPKDTLALAHIGQAYDSPMRLVETTIEVNERQKLNMVEKIETAYEGGLAGRKLAILGLTFKPKTDDMRDAPSLTIIRELEKRGVSFRVYDPAGMEEGRWRLEGVRGLEFCTDEYSAMEGCDGVVIVTEWHQFRNLDLKRVQELLVSPNFFDLRNIYDKAEMANQGFAYYGVGV
>NC_015690.1|WP_013914720.1|1005558_1006803_-|glycosyltransferase
MRFLLLWALAALGYWLVLLWDTLRAKKWMFTLPPSAGNTRINHQSNIQGSPDSSTRRASLTDAPLVSVIIAAKEEESSITETVRHLLSQNYPRLEIIAVNDRSRDATGRKLDELRRWSESKADITVPLRVIHITTLPQGWLGKNHALYQGYLQARGKLLLFTDADVRFHPDTVADAVRYLQEEQADHLTLSPDMMVKGLWLKAFVDYFFFTLCLYLRPWRANDDFQFKAGMGIGAFNLMTRYGYEKIGTHRAIAMRPDDDLQLGRHVKQARLRQRLASGHHHIGVEWYKSLGGAVEGLEKNIFSGFGYRTGLAILAVLGQLALFLYPVLGMLLIPGGTAWICALAVVTMAAVYLLLIRSLTGKAGWTVLLLPLTTGLLCYVVVRSVWLTLKQGGIYWRGTFYSLKELRRMQEEN
>NC_015690.1|WP_013914721.1|1006979_1007537_+|spore-protease-YyaC
MTGEQAKPLFRKKIRAAELPEFLRMIRSEGVSAENLQFLCIGTDRSTGDALGPLVGTMLEEAGFRGVIGTLARPFDASNMRERLAEIPPGRKVIAIDACLGQPASLGWYQVSNRPIEPGKSVGKQLPHVGDYSIAAIVNVDAGQKYAILQSTSLHRVMNMAREITAGILGTFLPGPLPAGPQEEE
>NC_015690.1|WP_013914722.1|1007536_1009360_+|ABC-transporter-ATP-binding-protein
MRQGGGFGEGGPMHRVQNRGRAKLEDVSTARIYRLFRGYRWQLAAILVMALGGAVLGLIPPLVMKEIIDHALPDGDRRQLVLLTVLMVLLPLLSGLLGVWQNHENTKVGQGVMRDLRQSLFGNLQRQAMSFFTDAKSGEIIQRLTGDVQAVQNVVTTLVVSAVTQSVIVLTTVVILFALDWQLAILSVAVLPLFLLPVRRVSAVRKKLRGEAQRVRGDMSARLGELFGVSGAMLTRIFQGERRQQEQFAVLNEKVMDLELRLNLVGRWYGMVIGVLGPLGTALIYLYGGWKVIDGSMTIGSIVAFAAYLGRLYGPVGTLLNLRVEVGTALGVFQRLFEYQDLVPEVREAENAKVLPPVRGHIAYRSVSYAYQPVQYALRGVSFEAAPGEVVAIVGPSGAGKSTLIGMLARLYDPTEGEVTVDGQDIRSVTLESLRSQVAFVTQESFLFHASVRDNLLFARADASPEELEEACRQAYIHEVIASLPAGYDTEVGERGHRLSGGERQRLAIARAILKNPRILILDEATSHLDSASEAYVQAALDELMRGRTTLVIAHRLSTILSADRIVVLEGGRVAESGRHEELLEKRGLYAKLFHTQFAAGGTPLSS
>NC_015690.1|WP_013914724.1|1009660_1009951_+|hypothetical-protein
MRQINHINITDTNGKIYCCLRNKIVTLDDHQKQKFCGGCKMFAGDAGGRGVECVWDDIRPVANPHIVNNPFTEMLSNQARRVNLTDHLSTVAVFGV
>NC_015690.1|WP_013914726.1|1010210_1010978_-|TSUP-family-transporter
MEWPSTDMLLFLIAAGFVASFIDSVVGGGGLVSVPALMLTGLPPSMVLGTNKLGGTLSSLTSTASFLASGKVSGRLVLLLFPLAFIGSAFGTYTVHLVPSSFMRPLVVVMLIAVLVYTLFKKNWDGTGVQLKWTGPRRLVIGLAALVIGFYDGFFGPGTGSFLLFVFLLFGFDFVGASANAKVLNFASNIASLAAFFLLDSVHLGYGIPMGLSMIAGALVGSQLAIRKGSTYVKPLFIIVTGILIGKQLWDLAAG
>NC_015690.1|WP_013914727.1|1011196_1011580_+|VOC-family-protein
MIHKLEHIGIMVSNMDASIRFYTEVLGLQLARREQIDNGPELGFLSFPGSEHIEIELIGRGTEGLSGSGIVNHVAFTVSDIEGEMARLQDLGVRFEEGSPKVILNGVRIAFFQGPDGERLELFQPAP
>NC_015690.1|WP_013914728.1|1011727_1012351_+|DUF3298-and-DUF4163-domain-containing-protein
MEWISGEDRAPRERIMTRRLVKPRLDVKYPQVAGLRNGFVQRMVNHAILDAVYDLIRIQGYVQDKTKTITGTYHVKLHQKELLSLLYENYGYAEKAAHGITYQSSQTFDLEDGRLYALADLFKPGSDYIGRLSKIIAREFKERDIPMIAEFKTITPEQPYYLTDKAIGIYFQLYEYTPYVYGFPTFEIPFAEVKDIIDPQGPIGRLM
>NC_015690.1|WP_013914729.1|1012538_1013210_+|NAD(P)H-binding-protein
MNKTAIVAGATGLIGRELVRQLTQDAAYGRVIALVRSRTDWEGGQPEELVTDWSEAQLEPLLRDKLPGADVYCALGTTIRKAGSKEQFRRVDLEYPLTLGRLARAHGASRLLVVSSTGADSSSRFFYSRVKGEMEEALRALGLPELHFFRPSLLLGQRKNDHRPGEKFAEAVSGAMPFLFRGPLQRYKPIQAAAVARGMIRAALREHGGEQVWESERIAELSR
>NC_015690.1|WP_013914730.1|1013333_1013648_-|hypothetical-protein
MNPGNKMKHSQPLPSARQIRRTCSRELYRARKKLGGWIPPEKVSQAEELYYKKVLLNLPYIAENGSNRKLLADWFDENVCGEIAELWSVEPEALGRAFRESFGG
>NC_015690.1|WP_013914731.1|1013720_1014839_-|GerAB/ArcD/ProY-family-transporter
MKAPILNARQLYCLVFLFELGSAVIVGLGMQAERDAWLAILIGMSAGLLLAVVFLYVYRRHEGHSLIGILQLRLGPAAGRLVGGIYVAYFLYIAARVLRDFGEVLVTTILNQTPLLSVNALMVVIICWSLSLGMEVIGRSAEIIIRLVSFMAIVTVPAILASDILEPRRFLPVLEKGLMPVLQTAFPLTLTFPFGETIVFLMVLPHLCSSRKAARPFLLAMLTAGLTLTAVVSLDIAVLGPGRAAAEQFPLLAALGKIQVGEVIQRLDAVALSTLILGGYFKITIFTYAGVRGLSELTRTSGRKAELAQLAAIGLLILAASVGMSASFPEHIDVGLKKVPYQMHLPLQVGVPVLLALLALVFSRRKRPYPSA

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Crispr_ID: NC_015690_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015690_3

1004713-1004907

Orphan

Consensus_repeat	Method
AACACGGAAAATCCGTGTAA	PILER-CR

3 spacers

The CRISPR arrays of NC_015690_3

>merge|NC_015690|3|1004713-1004907|PILER-CR
AACACGGATAATCCGTGTAAGATGAGCGGGAGTGCGCCCTGAAGCGCAGCAGCGATGGGTTAACACGGAAAATCCGTGTTAGGTAGTGAGCAGCCGTTCTTCGGTGGCCCCGGAACACGGAAAAACCGTGTAAAACGAGCGGGAGTGCGCCCCGAGGAGCAGCAGCGGCTGGGTTAACACGGAAAATCCGTGTTG

>NC_015690|3|2|1004713-1004907|PILER-CR
AACACGGATAATCCGTGTAA	GATGAGCGGGAGTGCGCCCTGAAGCGCAGCAGCGATGGGTT
AACACGGAAAATCCGTGTTA	GGTAGTGAGCAGCCGTTCTTCGGTGGCCCCGG
AACACGGAAAAACCGTGTAA	AACGAGCGGGAGTGCGCCCCGAGGAGCAGCAGCGGCTGGGTT
AACACGGAAAATCCGTGTTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_015690.1\|WP_013914727.1\|1011196_1011580_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319898
NC_015690.1\|WP_013914729.1\|1012538_1013210_+\|NAD(P)H-binding-protein	unknown	unknown	gnl\|CDD\|187560
NC_015690.1\|WP_013914730.1\|1013333_1013648_-\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013914721.1\|1006979_1007537_+\|spore-protease-YyaC	unknown	unknown	gnl\|CDD\|115518
NC_015690.1\|WP_013914710.1\|998523_999318_+\|thymidylate-synthase	unknown	unknown	gnl\|CDD\|234984
NC_015690.1\|WP_013914722.1\|1007536_1009360_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_015690.1\|WP_013914716.1\|1003839_1004340_+\|copper-amine-oxidase-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|377924
NC_015690.1\|WP_013914708.1\|996386_997709_+\|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|223936
NC_015690.1\|WP_013914728.1\|1011727_1012351_+\|DUF3298-and-DUF4163-domain-containing-protein	unknown	unknown	gnl\|CDD\|378702
NC_015690.1\|WP_013914731.1\|1013720_1014839_-\|GerAB/ArcD/ProY-family-transporter	unknown	unknown	gnl\|CDD\|281794
NC_015690.1\|WP_013914711.1\|999380_999890_+\|dihydrofolate-reductase	unknown	unknown	gnl\|CDD\|365932
NC_015690.1\|WP_013914713.1\|1000420_1001272_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NC_015690.1\|WP_013914714.1\|1001437_1002829_+\|glycoside-hydrolase-family-4	unknown	unknown	gnl\|CDD\|133433
NC_015690.1\|WP_013914720.1\|1005558_1006803_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|213815
NC_015690.1\|WP_013914715.1\|1003076_1003607_+\|DUF1572-family-protein	unknown	unknown	gnl\|CDD\|311521
NC_015690.1\|WP_013914726.1\|1010210_1010978_-\|TSUP-family-transporter	unknown	unknown	gnl\|CDD\|182593
NC_015690.1\|WP_013914724.1\|1009660_1009951_+\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013914709.1\|997730_998375_+\|LPS-biosynthesis-protein	unknown	unknown	gnl\|CDD\|226453
NC_015690.1\|WP_187296720.1\|1004429_1004603_-\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013914712.1\|999984_1000302_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_015690.1\|WP_013914727.1\|1011196_1011580_+\|VOC-family-protein	gnl\|CDD\|319898	cd06587, VOC, vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). Type I extradiol dioxygenases catalyze the incorporation of both atoms of molecular oxygen into aromatic substrates, which results in the cleavage of aromatic rings. They are key enzymes in the degradation of aromatic compounds. Type I extradiol dioxygenases include class I and class II enzymes. Class I and II enzymes show sequence similarity; the two-domain class II enzymes evolved from a class I enzyme through gene duplication. Glyoxylase I catalyzes the glutathione-dependent inactivation of toxic methylglyoxal, requiring zinc or nickel ions for activity. The antibiotic resistance proteins in this family use a variety of mechanisms to block the function of antibiotics. Bleomycin resistance protein (BLMA) sequesters bleomycin's activity by directly binding to it. Whereas, three types of fosfomycin resistance proteins employ different mechanisms to render fosfomycin inactive by modifying the fosfomycin molecule. Although the proteins in this superfamily are functionally distinct, their structures are similar. The difference among the three dimensional structures of the three types of proteins in this superfamily is interesting from an evolutionary perspective. Both glyoxalase I and BLMA show domain swapping between subunits. However, there is no domain swapping for type 1 extradiol dioxygenases.	7.15408e-20
NC_015690.1\|WP_013914729.1\|1012538_1013210_+\|NAD(P)H-binding-protein	gnl\|CDD\|187560	cd05250, CC3_like_SDR_a, CC3(TIP30)-like, atypical (a) SDRs. Atypical SDRs in this subgroup include CC3 (also known as TIP30) which is implicated in tumor suppression. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine rich NAD(P)-binding motif that resembles the extended SDRs, and have an active site triad of the SDRs (YXXXK and upstream Ser), although the upstream Asn of the usual SDR active site is substituted with Asp. For CC3, the Tyr of the triad is displaced compared to the usual SDRs and the protein is monomeric, both these observations suggest that the usual SDR catalytic activity is not present. NADP appears to serve an important role as a ligand, and may be important in the interaction with other macromolecules. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	3.89311e-69
NC_015690.1\|WP_013914722.1\|1007536_1009360_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	1.86299e-178
NC_015690.1\|WP_013914710.1\|998523_999318_+\|thymidylate-synthase	gnl\|CDD\|234984	PRK01827, thyA, thymidylate synthase; Reviewed.	0
NC_015690.1\|WP_013914716.1\|1003839_1004340_+\|copper-amine-oxidase-N-terminal-domain-containing-protein	gnl\|CDD\|377924	pfam07833, Cu_amine_oxidN1, Copper amine oxidase N-terminal domain. Copper amine oxidases catalyze the oxidative deamination of primary amines to the corresponding aldehydes, while reducing molecular oxygen to hydrogen peroxide. These enzymes are dimers of identical subunits, each comprising four domains. The N-terminal domain, which is absent in some amine oxidases, consists of a five-stranded antiparallel beta sheet twisted around an alpha helix. The D1 domains from the two subunits comprise the 'stalk' of the mushroom-shaped dimer, and interact with each other but do not pack tightly against each other.	1.04985e-23
NC_015690.1\|WP_013914708.1\|996386_997709_+\|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	gnl\|CDD\|223936	COG1004, Ugd, Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane].	0
NC_015690.1\|WP_013914728.1\|1011727_1012351_+\|DUF3298-and-DUF4163-domain-containing-protein	gnl\|CDD\|378702	pfam11738, DUF3298, Protein of unknown function (DUF3298). This family of bacterial protein C-terminal regions is highly conserved but the function is not known. Several members are annotated as being endo-1,4-beta-xylanase-like, but this could not be confirmed, and the structure can be defined as a heat-shock cognate 70kd protein 44kd ATPase.	1.23315e-15
NC_015690.1\|WP_013914731.1\|1013720_1014839_-\|GerAB/ArcD/ProY-family-transporter	gnl\|CDD\|281794	pfam03845, Spore_permease, Spore germination protein.	3.09674e-48
NC_015690.1\|WP_013914711.1\|999380_999890_+\|dihydrofolate-reductase	gnl\|CDD\|365932	pfam00186, DHFR_1, Dihydrofolate reductase.	2.26785e-83
NC_015690.1\|WP_013914714.1\|1001437_1002829_+\|glycoside-hydrolase-family-4	gnl\|CDD\|133433	cd05297, GH4_alpha_glucosidase_galactosidase, Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases. Glucosidases cleave glycosidic bonds to release glucose from oligosaccharides. Alpha-glucosidases and alpha-galactosidases release alpha-D-glucose and alpha-D-galactose, respectively, via the hydrolysis of alpha-glycopyranoside bonds. Some bacteria simultaneously translocate and phosphorylate disaccharides via the phosphoenolpyruvate-dependent phosphotransferase system (PEP-PTS). After translocation, these phospho-disaccharides may be hydrolyzed by the GH4 glycoside hydrolases such as the alpha-glucosidases. Other organsisms (such as archaea and Thermotoga maritima) lack the PEP-PTS system, but have several enzymes normally associated with the PEP-PTS operon. Alpha-glucosidases and alpha-galactosidases are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.	8.90846e-96
NC_015690.1\|WP_013914720.1\|1005558_1006803_-\|glycosyltransferase	gnl\|CDD\|213815	TIGR03469, HpnB, hopene-associated glycosyltransferase HpnB. This family of genes include a glycosyl transferase, group 2 domain (pfam00535) which are responsible, generally for the transfer of nucleotide-diphosphate sugars to substrates such as polysaccharides and lipids. The genes of this family are often found in the same genetic locus with squalene-hopene cyclase genes, and are never associated with genes for the metabolism of phytoene. Indeed, the members of this family appear to never be found in a genome lacking squalene-hopene cyclase (SHC), although not all genomes encoding SHC have this glycosyl transferase. In the organism Zymomonas mobilis the linkage of this gene to hopanoid biosynthesis has been noted and the gene named HpnB. Hopanoids are known to feature polar glycosyl head groups in many organisms.	1.51989e-30
NC_015690.1\|WP_013914715.1\|1003076_1003607_+\|DUF1572-family-protein	gnl\|CDD\|311521	pfam07609, DUF1572, Protein of unknown function (DUF1572). These proteins, from several diverse bacteria, share a short conserved sequence towards their N termini.	1.20524e-85
NC_015690.1\|WP_013914726.1\|1010210_1010978_-\|TSUP-family-transporter	gnl\|CDD\|182593	PRK10621, PRK10621, hypothetical protein; Provisional.	1.79122e-40
NC_015690.1\|WP_013914709.1\|997730_998375_+\|LPS-biosynthesis-protein	gnl\|CDD\|226453	COG3944, COG3944, Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane].	9.79244e-37
NC_015690.1\|WP_013914713.1\|1000420_1001272_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	1.3079e-25
NC_015690.1\|WP_013914721.1\|1006979_1007537_+\|spore-protease-YyaC	gnl\|CDD\|115518	pfam06866, DUF1256, Protein of unknown function (DUF1256). This family consists of several uncharacterized bacterial proteins which seem to be specific to the orders Clostridia and Bacillales. Family members are typically around 180 residues in length. The function of this family is unknown. These proteins are related to peptidase family M63 and so may be peptidases.	5.47611e-51

>NC_015690.1|WP_187296720.1|1004429_1004603_-|hypothetical-protein
MLENRGGNASRLALLSLPQTKKPGIGLPGSASSGKGPALDLAAARFAEVASGWTAAD
>NC_015690.1|WP_013914716.1|1003839_1004340_+|copper-amine-oxidase-N-terminal-domain-containing-protein
MKRKMLGIWAGLLLFAAPVHAREEAPVVRVFVDGEQVIFEHPPILEQGTTLVPFRAISEKLGFEVAYRVENGEQSVTAVKGGETVTMYIGNRIANSAEGRVLLEQAPRIEHDLAYVPLRFLAEAMHVEVEWDGEQTAVRLHTQAPADGGAPPEEKAADPEPEAAGA
>NC_015690.1|WP_013914715.1|1003076_1003607_+|DUF1572-family-protein
MGEAQELGKVMLEESIQAFRSMKALGDRTLAQLEDVQFGEALDPESNSMEVLIRHMHGNMVSRWTDFLTTDGEKPDRDRDGEFEGAGAGREELLALWEAGWAVVFGTLESLQPADLLRTVTIRGEAHTVVKAIQRQVSHYGYHVGQMVFLGKHLRSESWQTLSIARGQSRAFRPGT
>NC_015690.1|WP_013914714.1|1001437_1002829_+|glycoside-hydrolase-family-4
MEETGISKPKVVVIGAGSLFFGRQSIWQMVQSQYLNQGTLALVDTDEERLSKMVTLAKMVAKENGVPLQVEGSTNRREVLQGADFVVLSFAKDSVKYRGIDCEVSLQYGIRMCSGDTIGPGGIFRAMRELPVIMECAKDIEEICPDAWVINYINPSTVHGIALSRYAPKLKSFALCDSHHMPHKKAHYAIRAGIIQHPSEFTEEIDRRFDLRIAGVNHFTWLLKAEYDGKDVMALIAEALRRSAGTENDGGDKGAKALHNDAITYELYDIFGSIPTCTAHTKEYVRYWQGLGKTEDAIPPLSIWETEDRYKRHEEMWRQVDDFISGPIPVADYMKIMGPDHATDIIESMVGNLGKRFFINTLNNGAVTNMNDDAFLELLSEVSLSDGIKPLPVGDMPRGIRGMQELVLDTHELTAEAVVERSFTKLRRAFMTDPLVNSIHDADLIIKELLEREKDIIPSYWYE
>NC_015690.1|WP_013914713.1|1000420_1001272_-|AraC-family-transcriptional-regulator
MNSTMPVMDIFNELSEFITLRMKSCKELTHDRDWHEHKAHSDYDLWFIQSGTVQIHIGETEHTANPGDVVFFYPGVPYRAASTDKGCRFIYAHFDFGMGTQQRILNDFRLSGIITRELIRDEAILFDNSFRQVERFGGTSGNRLHLKACMTALIAKIIELYGKGHYHGTFPKERMRGHSQGKLDLLQPVFQYIHNHLHQSIRMSELASLVGISEKYFISYFKKALGLTPGQYIYQIKMNRARDYLYEKKYTVHQIAGFLGYPDPFTFSKAFKKYYDVPPSKFV
>NC_015690.1|WP_013914712.1|999984_1000302_+|hypothetical-protein
MTEVNQHQMPNRHVIDNVEKAIQVAKDAEMAVRHAQLESNPQKLRTALAQLETAQHALGNAQAQLNSRDREHHGQEFVQVQNELTQSEQSLDITSQNTELPKQVR
>NC_015690.1|WP_013914711.1|999380_999890_+|dihydrofolate-reductase
MTVSYMFAMDEARGLGYQNRMPWYLPADFAYFKQTTLEHTVLMGRKTFDSLGGKSLPRRRNVILTRDKSFEAPGCETVTSPEDAVKPYRPGGEQADEELFVIGGAEIFSLLMPYADRMYITEIHHTFEVDTYFPELDRTEWKEVSRTKGPKDERNPYDYEFVIYERAAN
>NC_015690.1|WP_013914710.1|998523_999318_+|thymidylate-synthase
MKAYLELLEDILEHGVSKEDRTGTGTLSVFGRQLRFNLAEGFPLLTTKKMHIKSILHELLWFLSGDTNINYLKENGVTIWDEWADENGDLGPVYGSQWRSWPAPDGRSIDQITAVVEALKKNPDSRRHLVSAWNPAEVDEMALPPCHYAFQFYVAGGKLSCMFQMRSVDTFLGLPFNIASYAFLTHMVAQQCDLEVGELIWTGGDVHIYSNHLEQVKLQLTREPYPQPQLVIKRKPDSILGYRYEDFEITGYQSHPAIKAPIAV
>NC_015690.1|WP_013914709.1|997730_998375_+|LPS-biosynthesis-protein
MELSELISIILRRIWILLIAVLVCVGAAAYVSYFHMEKEYEASASMYVLKSNKTPSNNLYQELLAGSSLVKDYKELIKSKTVLKQVKDQLERSHTWAAQMTVEQLSQKLEISNKNDTHILVAAAKDTSPERAAVIANQVAVVFIEYSRQITVDESVQLIDAAEAADAPSQPKPLINMAVAAVVGVLVGLLAIFLQVQSQRSTTARRGKKPLEFS
>NC_015690.1|WP_013914708.1|996386_997709_+|UDP-glucose/GDP-mannose-dehydrogenase-family-protein
MQKIAVVGTGYVGLVTGTCLSDFGLETICVDIDETKIKRLKEGHIPIYEPGLEEMVTRNIQYRRLEFTTDIQSAVEQAEVIFIAVGTPAREDGSADLKYVLTVAEQIARSMNGYKVIVNKSTVPVGTGQKVKEVVQQVLDETGKSFEFDVVSNPEFLREGNALHDFTHPDKVVVGTESQRAKDIMKQVYRVLYLNETPFIFTNIETAEMIKYANNAFLAVKISFINEIANLCEKVGANVQQLAQAIGKDGRIGSKFLHAGPGYGGSCFPKDTLALAHIGQAYDSPMRLVETTIEVNERQKLNMVEKIETAYEGGLAGRKLAILGLTFKPKTDDMRDAPSLTIIRELEKRGVSFRVYDPAGMEEGRWRLEGVRGLEFCTDEYSAMEGCDGVVIVTEWHQFRNLDLKRVQELLVSPNFFDLRNIYDKAEMANQGFAYYGVGV
>NC_015690.1|WP_013914720.1|1005558_1006803_-|glycosyltransferase
MRFLLLWALAALGYWLVLLWDTLRAKKWMFTLPPSAGNTRINHQSNIQGSPDSSTRRASLTDAPLVSVIIAAKEEESSITETVRHLLSQNYPRLEIIAVNDRSRDATGRKLDELRRWSESKADITVPLRVIHITTLPQGWLGKNHALYQGYLQARGKLLLFTDADVRFHPDTVADAVRYLQEEQADHLTLSPDMMVKGLWLKAFVDYFFFTLCLYLRPWRANDDFQFKAGMGIGAFNLMTRYGYEKIGTHRAIAMRPDDDLQLGRHVKQARLRQRLASGHHHIGVEWYKSLGGAVEGLEKNIFSGFGYRTGLAILAVLGQLALFLYPVLGMLLIPGGTAWICALAVVTMAAVYLLLIRSLTGKAGWTVLLLPLTTGLLCYVVVRSVWLTLKQGGIYWRGTFYSLKELRRMQEEN
>NC_015690.1|WP_013914721.1|1006979_1007537_+|spore-protease-YyaC
MTGEQAKPLFRKKIRAAELPEFLRMIRSEGVSAENLQFLCIGTDRSTGDALGPLVGTMLEEAGFRGVIGTLARPFDASNMRERLAEIPPGRKVIAIDACLGQPASLGWYQVSNRPIEPGKSVGKQLPHVGDYSIAAIVNVDAGQKYAILQSTSLHRVMNMAREITAGILGTFLPGPLPAGPQEEE
>NC_015690.1|WP_013914722.1|1007536_1009360_+|ABC-transporter-ATP-binding-protein
MRQGGGFGEGGPMHRVQNRGRAKLEDVSTARIYRLFRGYRWQLAAILVMALGGAVLGLIPPLVMKEIIDHALPDGDRRQLVLLTVLMVLLPLLSGLLGVWQNHENTKVGQGVMRDLRQSLFGNLQRQAMSFFTDAKSGEIIQRLTGDVQAVQNVVTTLVVSAVTQSVIVLTTVVILFALDWQLAILSVAVLPLFLLPVRRVSAVRKKLRGEAQRVRGDMSARLGELFGVSGAMLTRIFQGERRQQEQFAVLNEKVMDLELRLNLVGRWYGMVIGVLGPLGTALIYLYGGWKVIDGSMTIGSIVAFAAYLGRLYGPVGTLLNLRVEVGTALGVFQRLFEYQDLVPEVREAENAKVLPPVRGHIAYRSVSYAYQPVQYALRGVSFEAAPGEVVAIVGPSGAGKSTLIGMLARLYDPTEGEVTVDGQDIRSVTLESLRSQVAFVTQESFLFHASVRDNLLFARADASPEELEEACRQAYIHEVIASLPAGYDTEVGERGHRLSGGERQRLAIARAILKNPRILILDEATSHLDSASEAYVQAALDELMRGRTTLVIAHRLSTILSADRIVVLEGGRVAESGRHEELLEKRGLYAKLFHTQFAAGGTPLSS
>NC_015690.1|WP_013914724.1|1009660_1009951_+|hypothetical-protein
MRQINHINITDTNGKIYCCLRNKIVTLDDHQKQKFCGGCKMFAGDAGGRGVECVWDDIRPVANPHIVNNPFTEMLSNQARRVNLTDHLSTVAVFGV
>NC_015690.1|WP_013914726.1|1010210_1010978_-|TSUP-family-transporter
MEWPSTDMLLFLIAAGFVASFIDSVVGGGGLVSVPALMLTGLPPSMVLGTNKLGGTLSSLTSTASFLASGKVSGRLVLLLFPLAFIGSAFGTYTVHLVPSSFMRPLVVVMLIAVLVYTLFKKNWDGTGVQLKWTGPRRLVIGLAALVIGFYDGFFGPGTGSFLLFVFLLFGFDFVGASANAKVLNFASNIASLAAFFLLDSVHLGYGIPMGLSMIAGALVGSQLAIRKGSTYVKPLFIIVTGILIGKQLWDLAAG
>NC_015690.1|WP_013914727.1|1011196_1011580_+|VOC-family-protein
MIHKLEHIGIMVSNMDASIRFYTEVLGLQLARREQIDNGPELGFLSFPGSEHIEIELIGRGTEGLSGSGIVNHVAFTVSDIEGEMARLQDLGVRFEEGSPKVILNGVRIAFFQGPDGERLELFQPAP
>NC_015690.1|WP_013914728.1|1011727_1012351_+|DUF3298-and-DUF4163-domain-containing-protein
MEWISGEDRAPRERIMTRRLVKPRLDVKYPQVAGLRNGFVQRMVNHAILDAVYDLIRIQGYVQDKTKTITGTYHVKLHQKELLSLLYENYGYAEKAAHGITYQSSQTFDLEDGRLYALADLFKPGSDYIGRLSKIIAREFKERDIPMIAEFKTITPEQPYYLTDKAIGIYFQLYEYTPYVYGFPTFEIPFAEVKDIIDPQGPIGRLM
>NC_015690.1|WP_013914729.1|1012538_1013210_+|NAD(P)H-binding-protein
MNKTAIVAGATGLIGRELVRQLTQDAAYGRVIALVRSRTDWEGGQPEELVTDWSEAQLEPLLRDKLPGADVYCALGTTIRKAGSKEQFRRVDLEYPLTLGRLARAHGASRLLVVSSTGADSSSRFFYSRVKGEMEEALRALGLPELHFFRPSLLLGQRKNDHRPGEKFAEAVSGAMPFLFRGPLQRYKPIQAAAVARGMIRAALREHGGEQVWESERIAELSR
>NC_015690.1|WP_013914730.1|1013333_1013648_-|hypothetical-protein
MNPGNKMKHSQPLPSARQIRRTCSRELYRARKKLGGWIPPEKVSQAEELYYKKVLLNLPYIAENGSNRKLLADWFDENVCGEIAELWSVEPEALGRAFRESFGG
>NC_015690.1|WP_013914731.1|1013720_1014839_-|GerAB/ArcD/ProY-family-transporter
MKAPILNARQLYCLVFLFELGSAVIVGLGMQAERDAWLAILIGMSAGLLLAVVFLYVYRRHEGHSLIGILQLRLGPAAGRLVGGIYVAYFLYIAARVLRDFGEVLVTTILNQTPLLSVNALMVVIICWSLSLGMEVIGRSAEIIIRLVSFMAIVTVPAILASDILEPRRFLPVLEKGLMPVLQTAFPLTLTFPFGETIVFLMVLPHLCSSRKAARPFLLAMLTAGLTLTAVVSLDIAVLGPGRAAAEQFPLLAALGKIQVGEVIQRLDAVALSTLILGGYFKITIFTYAGVRGLSELTRTSGRKAELAQLAAIGLLILAASVGMSASFPEHIDVGLKKVPYQMHLPLQVGVPVLLALLALVFSRRKRPYPSA

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Crispr_ID: NC_015690_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015690_5

1257608-1257795

Orphan

Consensus_repeat	Method
AATAGCGGAACTCAGATGCGCTAT	CRISPRCasFinder

3 spacers

The CRISPR arrays of NC_015690_5

>merge|NC_015690|5|1257608-1257795|CRISPRCasFinder
AATAGCGGAACTCAGATGCGCTATCGCGGTATTTCCCGTCATTTCCCGGAGAATAGCGGAACTCAGATGCGTTATTGGCCGGAAAGGCCTCGATAAGGAGCCCGGAGTGATGGAATAAGGCATCACAGTTCCGCTATTTCGCTGGACGGTTCGTTTAGGCTGAGAATAGCGAATCAGAGTTCCGCTAT

>NC_015690|5|2|1257608-1257795|CRISPRCasFinder
AATAGCGGAACTCAGATGCGCTAT	CGCGGTATTTCCCGTCATTTCCCGGAG
AATAGCGGAACTCAGATGCGTTAT	TGGCCGGAAAGGCCTCGATAAGGAGCCCGGAGTGATGG
AATAAGGCATCACAGTTCCGCTAT	TTCGCTGGACGGTTCGTTTAGGCTGAG
AATAGCGAATCAGAGTTCCGCTAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_015690.1\|WP_013914981.1\|1255358_1256726_-\|YheC/YheD-family-protein	unknown	unknown	gnl\|CDD\|373047
NC_015690.1\|WP_013914991.1\|1267630_1268407_-\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NC_015690.1\|WP_013914979.1\|1253039_1254146_-\|YheC/YheD-family-protein	unknown	unknown	gnl\|CDD\|373047
NC_015690.1\|WP_013914978.1\|1252266_1252947_+\|HAD-hydrolase-like-protein	unknown	unknown	gnl\|CDD\|136007
NC_015690.1\|WP_013914989.1\|1265633_1266092_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NC_015690.1\|WP_081473149.1\|1261071_1261476_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|199890
NC_015690.1\|WP_013914974.1\|1248336_1248933_+\|DUF975-family-protein	unknown	unknown	gnl\|CDD\|283754
NC_015690.1\|WP_013914980.1\|1254152_1255358_-\|YheC/YheD-family-protein	unknown	unknown	gnl\|CDD\|373047
NC_015690.1\|WP_013914971.1\|1245522_1246359_-\|SHOCT-domain-containing-protein	unknown	unknown	gnl\|CDD\|378276
NC_015690.1\|WP_013914988.1\|1264257_1265637_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340879
NC_015690.1\|WP_013914994.1\|1269516_1269843_-\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013914986.1\|1261985_1262594_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379534
NC_015690.1\|WP_013914995.1\|1270207_1271554_+\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|226594
NC_015690.1\|WP_013914993.1\|1269046_1269328_+\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013914990.1\|1266806_1267634_-\|HAD-family-phosphatase	unknown	unknown	gnl\|CDD\|223635
NC_015690.1\|WP_041616569.1\|1244275_1244773_+\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_041616570.1\|1244964_1245177_+\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_014369072.1\|1251646_1252213_+\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013914983.1\|1259324_1260692_-\|YheC/YheD-family-protein	unknown	unknown	gnl\|CDD\|373047
NC_015690.1\|WP_013914972.1\|1247144_1247588_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_015690.1\|WP_013914981.1\|1255358_1256726_-\|YheC/YheD-family-protein	gnl\|CDD\|373047	pfam14398, ATPgrasp_YheCD, YheC/D like ATP-grasp. A member of the ATP-grasp fold predicted to be involved in the modification/biosynthesis of spore-wall and capsular proteins.	5.71481e-107
NC_015690.1\|WP_013914991.1\|1267630_1268407_-\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	1.05818e-81
NC_015690.1\|WP_013914979.1\|1253039_1254146_-\|YheC/YheD-family-protein	gnl\|CDD\|373047	pfam14398, ATPgrasp_YheCD, YheC/D like ATP-grasp. A member of the ATP-grasp fold predicted to be involved in the modification/biosynthesis of spore-wall and capsular proteins.	2.43971e-104
NC_015690.1\|WP_013914978.1\|1252266_1252947_+\|HAD-hydrolase-like-protein	gnl\|CDD\|136007	PRK06698, PRK06698, bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Validated.	1.99014e-41
NC_015690.1\|WP_013914989.1\|1265633_1266092_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	3.71064e-20
NC_015690.1\|WP_081473149.1\|1261071_1261476_+\|hypothetical-protein	gnl\|CDD\|199890	cd02860, E_set_Pullulanase, Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase). E or "early" set domains are associated with the catalytic domain of pullulanase at either the N-terminal or C-terminal end, and in a few instances at both ends. Pullulanase is an enzyme with activity similar to that of isoamylase; it cleaves 1,6-alpha-glucosidic linkages in pullulan, amylopectin, and glycogen, and in alpha-and beta-amylase limit-dextrins of amylopectin and glycogen. The E set domain of pullulanase may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end and may be involved in homodimeric/tetrameric/dodecameric interactions. Members of this family include members of the alpha amylase family, sialidase, galactose oxidase, cellulase, cellulose, hyaluronate lyase, chitobiase, and chitinase. This domain is also a member of the CBM48 (Carbohydrate Binding Module 48) family whose members include maltooligosyl trehalose synthase, starch branching enzyme, glycogen branching enzyme, glycogen debranching enzyme, isoamylase, and the beta subunit of AMP-activated protein kinase.	7.68946e-28
NC_015690.1\|WP_013914974.1\|1248336_1248933_+\|DUF975-family-protein	gnl\|CDD\|283754	pfam06161, DUF975, Protein of unknown function (DUF975). Family of uncharacterized bacterial proteins.	8.72575e-34
NC_015690.1\|WP_013914980.1\|1254152_1255358_-\|YheC/YheD-family-protein	gnl\|CDD\|373047	pfam14398, ATPgrasp_YheCD, YheC/D like ATP-grasp. A member of the ATP-grasp fold predicted to be involved in the modification/biosynthesis of spore-wall and capsular proteins.	3.30362e-102
NC_015690.1\|WP_013914983.1\|1259324_1260692_-\|YheC/YheD-family-protein	gnl\|CDD\|373047	pfam14398, ATPgrasp_YheCD, YheC/D like ATP-grasp. A member of the ATP-grasp fold predicted to be involved in the modification/biosynthesis of spore-wall and capsular proteins.	5.22778e-102
NC_015690.1\|WP_013914988.1\|1264257_1265637_-\|MFS-transporter	gnl\|CDD\|340879	cd17321, MFS_MMR_MDR_like, Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	6.66518e-46
NC_015690.1\|WP_013914995.1\|1270207_1271554_+\|CBS-domain-containing-protein	gnl\|CDD\|226594	COG4109, COG4109, Predicted transcriptional regulator containing CBS domains [Transcription].	0
NC_015690.1\|WP_013914990.1\|1266806_1267634_-\|HAD-family-phosphatase	gnl\|CDD\|223635	COG0561, Cof, Predicted hydrolases of the HAD superfamily [General function prediction only].	5.00082e-45
NC_015690.1\|WP_013914986.1\|1261985_1262594_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|379534	pfam14278, TetR_C_8, Transcriptional regulator C-terminal region. This domain is a tetracycline repressor, domain 2, or C-terminus.	4.08692e-18
NC_015690.1\|WP_013914971.1\|1245522_1246359_-\|SHOCT-domain-containing-protein	gnl\|CDD\|378276	pfam09851, SHOCT, Short C-terminal domain.	2.47323e-06

>NC_015690.1|WP_013914981.1|1255358_1256726_-|YheC/YheD-family-protein
MSLTTCTIHVTQRQERAVYLSGDLAKALKLSKTRTVTLKLGSKSVSLSLKLLKKSGNHLYLTPTVYTQLKFPRNGTTMVTTSSGRDIRLGPLIGILTNVVKSTTSPFGSRTEFIREFMRAGSDKAFYFGFSPSDVNWTQETVSAIVPRSEGGWVRKVLPLPDVVYNRLPSRRAEKLASMNAFKQRFIRRGIPLFNWSFFDKWDVYHLLEGTDAFRYVPESKINPNSTQVKEMLEKHKFIYLKPTAGSLGIGIYRLTYNPKRGYYARFRKGSRNVLLRFSRFESLIAHVNRHSNNMQGYVIQQGIRLIEIDSCPIDFRFHMTKNSSNQWVVAAIGAKKAGKGSVTTHVRTGGMLMTPEQVLRQIFGSRADTVLTNAKESAIKLAEDIETKHRHTLGELGFDIGIDQNERIWMFEANSKPGRSIFKHPALKEQGKASLQYIYDYCLYLSRFRSRRES
>NC_015690.1|WP_013914980.1|1254152_1255358_-|YheC/YheD-family-protein
MDLHAQQKKTGRPTMAILTYVDEKRIFRGNQDNFIDLIRKGEEHGVLVYVMTTADFKLSGDTAVGYTYAASSKKWKRQVFPLPHVIYNRIPYRKFELLPEVQQILQTCLRHRQIHFFNPSFFNKWTLFEWLSKSKETRSVIPATQRLSPGGEEIETLLGSYPFLYLKPIRGKAGKGIMKVSRVENSSKSRMFELSIQDKTKSHISRYPSTRQLWTELGPLVGSQDYIVQQGITLSLYKQRPFDLRVLVQKNGKGAWSVAGIGARLAGKMSITTHVPRGGSIDDPAKLLAYSFGTTTAKKILIRAKKTALTVARRIESASGHILGEMSMDLGVDSDGRIWFFEANSKPMKFDEPPIRQKSLENLIQYCIHLSKLKRSAAAGDSAVSLQQLTGVRRPTPRRRG
>NC_015690.1|WP_013914979.1|1253039_1254146_-|YheC/YheD-family-protein
MSRQLGVLAMYLPGRKLEELSFFRKLCVSGRKLGLEVLVFTPDDVNEDGTRIQAMTYDPEKGSWVRRSCGFPPLIYDRCRYHGVENYRKLTRFRSRYAKLRYLSRPLANKWTVHQALAEHDEILPHLPATVRYHSVKDVEDLLKSHGVIYMKPKSGTGGRGIVRLQRLQGGDAVLLQGRDPGRRILPVQKLAVRHLPSKLAGWKLEEKYIIQQGIPLTLKDGRVHDFRMLVQKDGEGQWQVTGCAGRIGPRRSVTSNLHGGGTAIPMETLLKNRFGSEEKVASIKKKAYSLGLLVVEHLEKRFGMQCEVGIDLAVDPKGGIWLLEVNPKPSREVFSRIGQRETYRQAVARPMEFAAWLYKQKISGVTR
>NC_015690.1|WP_013914978.1|1252266_1252947_+|HAD-hydrolase-like-protein
MTARTMPEAMIFDVDGTLFQTETLLLPAYHATFDRLRSEGLYVGETPPEQYILGSLGMLLEHIWQQVIPESDVAVHRRADELLLHYQVEGMARGEGLLYEGVAETLKELRARGIRLFTASNGLEGYVKGVIRAQGLEPLFESGGLFSAGEHSTRSKVDLVRKLLDQYGIRSAWMVGDRSSDVEAGHANGLFVVGCDYAGFRKEGELDEADVRIRDFREIVGLLPER
>NC_015690.1|WP_014369072.1|1251646_1252213_+|hypothetical-protein
MVTLACFLRVKGWKDLDRFHSTVLYMISANVLYFVFTTNYLLWAFVPDVPLYPILNELLYTLIVFPCSVVLFLKGCPEEKGLPVWHYLKWVAFFAVPEALYAYTGHIAYGHGWSWGWSAAFDLMMFPMLWLHSRRPVLAYVLSVGITTLLLLLFRVPLAGLMEFDGATSGGPDWFTLTSPLSAWFYEG
>NC_015690.1|WP_013914974.1|1248336_1248933_+|DUF975-family-protein
MEGIASITELKTRALEQLRGNWFKAAVVTLIVVGLSLLVSEIPKVGSLISLLISGPISWGSAYFFLRLRRGEGASIEDILQGFVRFVPALVLYLLTTLFVLLWMLLLIVPGIVAALSYSMAYYIRIDEPELSAMEALRRSKEMMKGHRWRFFVLGLSFIGWILLAVVTAGIGFLWVGPYMSVTSANFYTNLKASQIHG
>NC_015690.1|WP_013914972.1|1247144_1247588_-|hypothetical-protein
MNFKKIAVTLAAVSMLTIGTQSAFAANYDERENNDSPYNIQYQDKLNYQTYMKGYLSSSNDQDWFLFTPDSIPGGRAIITLVSPEGYNYGIYLTTSNGSRVSKTWLIDDGRTQQFMIYTQPGESYHINVTNSGLDVNPNMPYNLSVI
>NC_015690.1|WP_013914971.1|1245522_1246359_-|SHOCT-domain-containing-protein
MGTLFSGNWFVALIILVSTLWGASYFFNKQKEIDEEENYRKELATRDKLNELPNFKVSQRYISPDGTTTLAIDEHSKQFSIAKYDRIPKSYKYSELLKSEIVTDGMSITSTNRGSQIGGALLGGLLTGGVGAIIGGLSASKSTEEKIKKIELVVVVNDSTVPVHRIAFLDSSSPYAKSSTEYKEAYDKAYHCHQLMSVLIRQADEDDRNTELPAIESSDQTNHIEDTKENRRNSTPEEAISLNISIADEIKKLAELRDEGILTSEEFENQKKKLLIYG
>NC_015690.1|WP_041616570.1|1244964_1245177_+|hypothetical-protein
MITGNVDLATLEPGDHIEVKYETDEDPEQVMGPFSGLRSRRGQKAAFYWPGIRGWQAKNVDPPGRHDLGK
>NC_015690.1|WP_041616569.1|1244275_1244773_+|hypothetical-protein
MENNMKSRVLIMTFIILSLTLVWVIQNYQKASQKALLDRSDPITLKIKWGASNNNYNSVGNSWDYQAAINGEKVPWESPAEYVVTSDAMIPIIARAEERDNYPDVGISRGQIDVSKLNLASITHVHLNVEVREGHGRYAGRVTHPHFIYTVERIITIRDILNHFF
>NC_015690.1|WP_013914983.1|1259324_1260692_-|YheC/YheD-family-protein
MKRTKVKIQIQSSGLSSDGSVVMLSEAVAKKWKIPFQQTLQLRFGSSRQDVRVVPLSQAGALRISGALASRWGLFKDDQLCLQYKSSSRTLVLGPLIGVMVSRVHPGSLDKMFGVNTAFCRELTDACRLYGASVFFSTPDDLQGQGDTVKGWRYTGTWERMTFPVPNVLYNRLTSRKLENLENVQQFVGHAKTRYNAVMFNEKYLNKTEVFDALRKETGLGTYLPESHLLRSFTMLKSMCTKHPTVFLKPITGSLGKGIIRVRRQPEGSYLCHFTSLNGARKQSFSTLTQLFNTIAGKVKTQKYQIQQGLNLLTVGGRPVDFRALVQRGDTGQWGITSIVARIAGSQHFVSNLARGGSLSTVKDALARSGSAASSGGLPKLRRAALSIAKGIESQVPGHFAELGIDLAIDTAGRVWLLEVNSKPSKEDNTPLDTERKIRPSVKGLVQYARFAAKF
>NC_015690.1|WP_081473149.1|1261071_1261476_+|hypothetical-protein
MAVQKENGRTISYGDARASGGLSVFSKKFDEAFFYDGDDLGVSLRGRETGFRLWAPTAWDAQVVLYPGGEGAADRYLPMKRGLRELTVPENLDGWCYTYRIRIGSQWDEAPDSYAKAVGINGERSVTGGNGRAA
>NC_015690.1|WP_013914986.1|1261985_1262594_-|TetR/AcrR-family-transcriptional-regulator
MNPIKEDRRVRKTRRAILDALLSLTREQGLHAVTVGGITDRADINRATFYAHYRDKQDLIEQAVSEVLSEWGTVEEHRWAGSGSEVDFDRLLPIFTHMFEKIGKHAEFYRIMLGPGGYPGFSENLRDVMCRLIRHSHHRVLELKRARPLVDPDIYLSYVTSAQLGVIIHWLHQETPHSPEYMAEQLMLLYRLGAVQAADYEG
>NC_015690.1|WP_013914988.1|1264257_1265637_-|MFS-transporter
MNPSQAGEKLIKVLAFTLVLSVMNATMFNVALPTLSKEFQLTASQVSWVVTAYIIVYAIGSVTYGKLADKYRLKDLLTIGLSFFALGSILGFVATEYWMIILARVLQSVGASVIPAAAMIIPVRYFPPETRGRALGTTSAGLALGTAIGPIIAGFVTSTLSWRYLFFLSVLSLLTLPFYRKYLDDNRGESGKTDLLGGGLLALTIAFLLLSITNSAWIYLGVAAIFFALFLVRIRRSANPFIQPALLNNRKYAAGLIVSFIASGLSFGIPFLTPQMLTQLNGLNPAVIGFVMFPGAIIASMLGKTGGRLADQKGNVYLIFLAIAAQFLSFFLLSVTAGIGPWVLWIFLIFGNIGQMFMQIGLSNTVSRTLAREQTGVGMGLFMMVNFIAGAIATSVIGKVLDAGRASVPHALNPLLIVSDGGVYSNIFLVLSVLVLVNTLLFYVFFGERAARRRGESLG
>NC_015690.1|WP_013914989.1|1265633_1266092_-|MarR-family-transcriptional-regulator
MDNKEYQLSDSLGYLLGNAYRLMSCRLGARFRERQYDVTIEQWPLLAQLWNQDGLTQAQLSALTRKDQPSVSRLVDNMIKKNLVVRVSHPEDRRKNRIHLTPKGAELQQKLIVEALANNADAIAGVSPEEYAVFRSVLERITANMKQMKEEL
>NC_015690.1|WP_013914990.1|1266806_1267634_-|HAD-family-phosphatase
MIKLIVSDLDGTMLLHEERQARTEDIDALKEAAAAGIAVAFASGRMHPEIQAVMEIFGMRTHSISQNGAYVHTQDGQLVQSSAFDTGLIKELAGAAAGTSLLTVLAAPESYVVQEWSEAAEALKPRLMAPLVEMPDLLEKLGDELVCGKLSYMGELAELKRLQEKLLARYGEIVDAYISDIDCLDVMPRTTSKGTGLKALLAVLGLTQEEAVCFGDSFNDLPMFAATPHSFAMGSAHPDVQAKAARTVPFVADALKWVRAYNAAGAQHPDAASSV
>NC_015690.1|WP_013914991.1|1267630_1268407_-|DeoR/GlpR-transcriptional-regulator
MYQEERLLAILQHMRHHHRISVEEICELFQVSRDTARRDIVKLEEQGHILRTRGGAILPSLNKDVPRFDDRLEAEKAVKEDIGRAAASLLQNGDYLFMDSSTTVLQAANHLTTADHVIVTNSFDIAGVLSHRPSTTVHLLGGVVHPRHRFIYGARTLEMLRDYQVDKLLIGTSGITESGLTNPYEEEGYVMKEMMRRADQIIVLADHTKFGQRQFFRLAGLEAIDILITDREPEAPMKQALLEHDIHIIITSEGEKES
>NC_015690.1|WP_013914993.1|1269046_1269328_+|hypothetical-protein
MGKGTRSVIYLGLSLGMLLFAVPRLDLAGGWSLPAVFGVVWCAFALLLVAAHLHELLGVEEETKRELLKVKRMKRWQLEQAVRGRRKMLQVRK
>NC_015690.1|WP_013914994.1|1269516_1269843_-|hypothetical-protein
MSTDAREPQAIYEADSSFIDTLNKYRERILNVCTEHLHKPVRVHTTHGQHHEGIIVHIDAYHIYLQLPPGHSRAFIPGPYGYPPYNPYYNNVILPLALFDLLAISLLL
>NC_015690.1|WP_013914995.1|1270207_1271554_+|CBS-domain-containing-protein
MTGQEGNWQEAATKHEQILKYIESLKIGSKISVRKIAEKLGVSEGTAYRAIKEADTLGLVATKERVGTVRVEKKLRDHMDRLTFAEVVNMVDGELLGGRGGLEKTLHKFVIGAMQQDAMLRYIDPGSLLIVGNRAKAHMCALEQGAGVLITGGFGTSEEVKELADRLELPIISSSYDTFTVASLINRAIYDRLIKKKILLIEDIVPSPMQVYVLKAHHTLRDWQRLHEETGHSRFPVVDEWNRAIGMITSKDLIGAEPGQTVDKFMTRNPVTAQPSTSVAAAAHMMVWEGIELLPIVDAGRKVTAVISRKDVLKAMQHIQRQPQHGETFEDLIWSGFSEERDRSGQILFRGTITPQMTNRLGTVSEGVLAVLMSQAAYHAVQDVKKGDLVLDNMSSYFVRPVQIDSQVELRPRIIEVSRKFGKIDVEMYHAGVLVAKAMLTAQVFDPS

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Crispr_ID: NC_015690_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015690_6

1290577-1290695

Orphan

Consensus_repeat	Method
GGCGGCTTTGCCGACCCGGGAAGAGCAGAACGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015690_6

>merge|NC_015690|6|1290577-1290695|CRISPRCasFinder
GGCGGCTTTGCCGACCCGGGAAGAGCAGAACGAAAAGCGGGAACAACGGGAAGAGCGGGGAAACGGAAGAAGAGCGGAATACACAGGCGGCTTCGCGGACCTGGAAAGCAAAGAACAGA

>NC_015690|6|3|1290577-1290695|CRISPRCasFinder
GGCGGCTTTGCCGACCCGGGAAGAGCAGAACGAA	AAGCGGGAACAACGGGAAGAGCGGGGAAACGGAAGAAGAGCGGAATACACA
GGCGGCTTCGCGGACCTGGAAAGCAAAGAACAGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_015690.1\|WP_013915002.1\|1278670_1279597_+\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta	unknown	unknown	gnl\|CDD\|235547
NC_015690.1\|WP_041616572.1\|1282595_1283039_+\|acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|223894
NC_015690.1\|WP_013915011.1\|1291882_1292680_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|315383
NC_015690.1\|WP_049819028.1\|1299746_1300820_+\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NC_015690.1\|WP_013915015.1\|1296011_1296989_+\|bile-acid:sodium-symporter-family-protein	unknown	unknown	gnl\|CDD\|223462
NC_015690.1\|WP_013915010.1\|1290723_1291665_+\|malate-dehydrogenase	unknown	unknown	gnl\|CDD\|180477
NC_015690.1\|WP_013915000.1\|1277699_1278194_+\|phosphatidylglycerophosphatase-A	unknown	unknown	gnl\|CDD\|224186
NC_015690.1\|WP_013915016.1\|1297075_1298878_+\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|380161
NC_015690.1\|WP_014369091.1\|1293614_1294199_-\|5'-deoxynucleotidase	unknown	unknown	gnl\|CDD\|378993
NC_015690.1\|WP_013915001.1\|1278426_1278618_+\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013915008.1\|1288787_1290083_+\|NADP-dependent-isocitrate-dehydrogenase	unknown	unknown	gnl\|CDD\|180792
NC_015690.1\|WP_014369094.1\|1298987_1299710_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_015690.1\|WP_014369090.1\|1293002_1293431_+\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013915004.1\|1280559_1282317_+\|pyruvate-kinase	unknown	unknown	gnl\|CDD\|235784
NC_015690.1\|WP_013915006.1\|1283175_1285275_+\|RNA-degradosome-polyphosphate-kinase	unknown	unknown	gnl\|CDD\|235469
NC_015690.1\|WP_013915007.1\|1287420_1288533_+\|citrate-synthase	unknown	unknown	gnl\|CDD\|184467
NC_015690.1\|WP_014649940.1\|1285240_1286782_-\|Ppx/GppA-family-phosphatase	unknown	unknown	gnl\|CDD\|223326
NC_015690.1\|WP_013915014.1\|1294445_1295984_+\|fumarate-hydratase	unknown	unknown	gnl\|CDD\|377546
NC_015690.1\|WP_013915003.1\|1279586_1280567_+\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha	unknown	unknown	gnl\|CDD\|235580
NC_015690.1\|WP_013915019.1\|1301046_1302129_+\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745

Protein	Function_ID	Function_description	E-value
NC_015690.1\|WP_013915002.1\|1278670_1279597_+\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta	gnl\|CDD\|235547	PRK05654, PRK05654, acetyl-CoA carboxylase carboxyltransferase subunit beta.	9.77981e-164
NC_015690.1\|WP_041616572.1\|1282595_1283039_+\|acyl-CoA-thioesterase	gnl\|CDD\|223894	COG0824, FcbC, Predicted thioesterase [General function prediction only].	4.93588e-44
NC_015690.1\|WP_013915011.1\|1291882_1292680_+\|alpha/beta-hydrolase	gnl\|CDD\|315383	pfam12695, Abhydrolase_5, Alpha/beta hydrolase family. This family contains a diverse range of alpha/beta hydrolase enzymes.	2.10633e-65
NC_015690.1\|WP_049819028.1\|1299746_1300820_+\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	1.0298e-57
NC_015690.1\|WP_013915015.1\|1296011_1296989_+\|bile-acid:sodium-symporter-family-protein	gnl\|CDD\|223462	COG0385, COG0385, Predicted Na+-dependent transporter [General function prediction only].	4.38394e-32
NC_015690.1\|WP_013915010.1\|1290723_1291665_+\|malate-dehydrogenase	gnl\|CDD\|180477	PRK06223, PRK06223, malate dehydrogenase; Reviewed.	0
NC_015690.1\|WP_013915000.1\|1277699_1278194_+\|phosphatidylglycerophosphatase-A	gnl\|CDD\|224186	COG1267, PgpA, Phosphatidylglycerophosphatase A and related proteins [Lipid metabolism].	1.11805e-38
NC_015690.1\|WP_013915016.1\|1297075_1298878_+\|PAS-domain-S-box-protein	gnl\|CDD\|380161	NF033092, HK_WalK, cell wall metabolism sensor histidine kinase WalK. This model describes WalK as found in Staphylococcus aureus (sp\|Q2G2U4.1\|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.	4.12565e-119
NC_015690.1\|WP_014369091.1\|1293614_1294199_-\|5'-deoxynucleotidase	gnl\|CDD\|378993	pfam12917, HD_2, HD containing hydrolase-like enzyme. This is a family of bacterial and archaeal hydrolases.	1.62245e-96
NC_015690.1\|WP_013915014.1\|1294445_1295984_+\|fumarate-hydratase	gnl\|CDD\|377546	pfam05681, Fumerase, Fumarate hydratase (Fumerase). This family consists of several bacterial fumarate hydratase proteins FumA and FumB. Fumarase, or fumarate hydratase (EC 4.2.1.2), is a component of the citric acid cycle. In facultative anaerobes such as Escherichia coli, fumarase also engages in the reductive pathway from oxaloacetate to succinate during anaerobic growth. Three fumarases, FumA, FumB, and FumC, have been reported in E. coli. fumA and fumB genes are homologous and encode products of identical sizes which form thermolabile dimers of Mr 120,000. FumA and FumB are class I enzymes and are members of the iron-dependent hydrolases, which include aconitase and malate hydratase. The active FumA contains a 4Fe-4S centre, and it can be inactivated upon oxidation to give a 3Fe-4S centre.	4.53657e-94
NC_015690.1\|WP_013915008.1\|1288787_1290083_+\|NADP-dependent-isocitrate-dehydrogenase	gnl\|CDD\|180792	PRK07006, PRK07006, isocitrate dehydrogenase; Reviewed.	0
NC_015690.1\|WP_014369094.1\|1298987_1299710_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	7.17047e-89
NC_015690.1\|WP_013915004.1\|1280559_1282317_+\|pyruvate-kinase	gnl\|CDD\|235784	PRK06354, PRK06354, pyruvate kinase; Provisional.	0
NC_015690.1\|WP_013915006.1\|1283175_1285275_+\|RNA-degradosome-polyphosphate-kinase	gnl\|CDD\|235469	PRK05443, PRK05443, polyphosphate kinase; Provisional.	0
NC_015690.1\|WP_013915007.1\|1287420_1288533_+\|citrate-synthase	gnl\|CDD\|184467	PRK14034, PRK14034, citrate synthase; Provisional.	0
NC_015690.1\|WP_014649940.1\|1285240_1286782_-\|Ppx/GppA-family-phosphatase	gnl\|CDD\|223326	COG0248, GppA, Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism].	1.18322e-102
NC_015690.1\|WP_013915003.1\|1279586_1280567_+\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha	gnl\|CDD\|235580	PRK05724, PRK05724, acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated.	0
NC_015690.1\|WP_013915019.1\|1301046_1302129_+\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	1.10658e-84

>NC_015690.1|WP_013915008.1|1288787_1290083_+|NADP-dependent-isocitrate-dehydrogenase
MAQFEQYALPTEGERITITNGVLNVPNNPIIPFIEGDGTGPDIWAASKRVLDAAVEKAYNGEKKIAWYEVFAGEKAFNKYNNWLPADTLTAIREYIVAIKGPLTTPIGGGIRSLNVALRQELDLYVCSRPVRYFKGVPSPVKRPELVDMVIFRENTEDIYAGIEWAAGSEEVKKVLAFLQNEMGVKKIRFPETSGIGVKPVSSEGSKRLVRAAIEYAIKHNRKTVTLVHKGNIMKFTEGAFKNWGYELAEEEFGDKTFTWAQYDRIKEESGADAANAAQKAAEAEGKIIVKDAIADIALQQVLTRPTDFDVIATLNLNGDYLSDALAAQVGGIGIAPGANINYVTGHAIFEATHGTAPKYAGLDVVNPGSVILSGVMMLEHLGWLEAAELIYKGMETAINNKTVTYDFARLMEGATEVKCSAFADQIIANF
>NC_015690.1|WP_013915007.1|1287420_1288533_+|citrate-synthase
MTATKGLEGIVATTSSISSIIDGVLTYRGINIDDLAENATFEEVVYLLWYGKLPNRSELNQLIQDLSSSAAVPAEVLDGIKLFPKNVNTMAALRTAVSSLALYDAEANDMTPESNLRKAIKLQAQLPTIVAAFARIRQGQEPIAPKSGVSIAENFLYMLTGRNPEKIAIEALDKALVLHADHELNASTFAARVTVATLSDIYSGVTSAIGALKGPLHGGANEAVMAMLEEIGTASNVTAYINEKLANKEKIMGFGHRVYKNGDPRAKHLMKMSEELGKITNNMNWYDMSIQIEELVTGQKGLKPNVDFYSASVYTSLEIPRDLFTPIFAISRTSGWTAHILEQYENNRLIRPRAEYTGPSHQAFIPIEQR
>NC_015690.1|WP_014649940.1|1285240_1286782_-|Ppx/GppA-family-phosphatase
MKDSKRIGIIDIGSNSIRLAIYELDSGGAYRVISEFKESARLSQKIGPDGALPPEEIQDLVRMLSHFKRICRSHEVTECRVAATAAVRNATNTEQIQETLSRETGWDIEILSGQDEARLGFLGMIQTMDIEDGFLVDIGGGSTEISLFRQRKLVHSVSFPFGAVNTTRKFAPDGEFGEGPLKAIREMVEEALAREPWIASSPGLPLVGLGGGVRTLCKINQRRRRYSLPQTHNYHLPAADVDELAAWLPGLPAEKRKKIDGLSKDRFDIIVPGMIILQTVFQTVKGSHYIVSGAGLRDGLFFEAFYPAVSSEKPIAEQSSDNLLALHSTAPAAHIQRVCRTALKLYDALAEGGTHRYSPRLRMCLHIAAKLYRIGASLLYYQYPKHSFHMIAHTRIDGLSHREMLLCALIASYKAKNRTQQAVQPFKDILKESDVDLIARLGTLLQLAVALDVSETQAIDVTAAFSENTSLHLRLLTLHDPSAEYREVEALQKDFRKIWGLQLKIHEPSFSTN
>NC_015690.1|WP_013915006.1|1283175_1285275_+|RNA-degradosome-polyphosphate-kinase
MKETAPREAAAANHYLNRDLSWVEFNWRVLEEAQDPTTPLLERVKFLSIVSSNLDEFMSVRVAGIVDQIKAGYTKKDFTGYTPAGLFKRVMKRAAKMVAEQYRTSREITRALAREGIILTSYDELNATQRKAMDEYYHEIVFPVLTPMAVDQARPFPLVHTQSLYLAVVLMKEGEDPEVEPYFAILQVPSNLNRFIEVPCRTNSKKHEYILLETLIEHHIHTLFSGYTPVSVHGFRLTRNADLTLNEEGAEDLLEEIEIQLRRRRWGAPVRLEVQRGIHPYALQQLIEEFEISDNIFEIDGPIDLTFFMKLSGSLQGYDHLRYPPIKPVYPAELENEDDLFLKLRQQDVLVYHPYESFDAVTDFVTQAAHDPHVLAIKMTLYRVSGNSPLIQGLAQAAESGKQVTVVVELKARFDEERNIAWARKLEQSGCHVVYGLVGLKTHAKITLVVRQEPDGLRRYVHVGTGNYNDNTAKLYTDVGLFTTDKIIGEDASALFNEVTGYSAPHNWKAFGVAPTDLMDKLIEKIRREARNASEGKPARIIAKFNSLSNQQMVDELYAASQAGVKIDLIIRGVCCLRPGVPGLSENITVRSIVDRFLEHSRIFYFENGGSEEIYLASADWMTRNLTRRVELMCPAFNKGIQQSLTRILQLNLDDNVKARQLQSNGMYERMTPAAGEPPLRSQFEAMRISSWKTKAREF
>NC_015690.1|WP_041616572.1|1282595_1283039_+|acyl-CoA-thioesterase
MKVERDQAQAARWFTHEVRVRYEETDQMGVVYHANYLTWFEIGRTEMIRSLGMPYQTLEARGLLLPLTEAEMKFRLPARYDDWVTIRVRVSEFSNLRLTFDCEILRGEDLLVTGRTKHVWLNRDWRPTRIDKEAPDLYALIKASSDC
>NC_015690.1|WP_013915004.1|1280559_1282317_+|pyruvate-kinase
MRKTKIVCTIGPVSESLEMFKKLINAGMNVARLNFSHGDFEEHGNRIKNVRQACQELGKSVAILLDTKGPEIRTGKLKDDQKVELVQDNLITLTTEEIVGDAERVYITYKDLYKDVRVGSTILIDDGLIGLTVEDIRGTDIVCRIKNGGLLGGKKGVNVPGVKINLPGITEKDANDIIFGIQQGVDFIAASFVRKASDVIEIREILERHNANHIQIISKIENQEGVENLDEILEVSDGLMVARGDLGVEIPAEDVPIVQKAMIKKCNQAGKPVITATMMLDSMQRNPRPTRAEASDVANAIFDGTDAVMLSGETAAGKYPVESVQTMARIAERAEAALEHREIFIRQSNAQQTTVTEAISQAVANSALDLDAKAILTATESGYTARMVSKYRPKAPIIAVTPDEKVLRRLSLVWGVVPIKGEMCTSTDQLFEHAVDTSLKAGLVSLGDLVVITAGVPVGRSGTTNLIKVHQIGEMIAKGQGIGTQIATGKVVTARTAEEAVAKTSEGCILVTVTTDKDYMPAFEKAAAVITETGGITSHAAVVGISLGKPVIVGVEKALEILKDDAEVTLYPEVGVIYSGRARVL
>NC_015690.1|WP_013915003.1|1279586_1280567_+|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha
MASEMPFEQPLVELRAKIEELRKFSSDKQIDFSDEIARLEQRLQQLESELYAGMSTKHKMQVARHPQRPTTLDYIQHLFTDFMELHGDRLYGDDLAIVGGIARFNGIPVTVVGHQKGKDTKDNIARHFGCPHPEGFRKALRLMKQADKFRRPIITFIDTKGAFPGNAAEERGQGEAIARNLMEMAAMRVPILCVVIGEGGSGGALALGVGNRVFMLENAIYSVISPEGAASILYKDASKSMEAAEAMKITADEILKLGVIDGIIPEPKGGAHRDPAAQAESIKDALWNALQELMAMSEQELIEDRYNKFRNIGRFTTIQEGNPNHA
>NC_015690.1|WP_013915002.1|1278670_1279597_+|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta
MQFKDLFQKKRKYATVPSTDRPAQSRVIDGAIDIPEERPRREIPEGLMNKCPKCGTIQYNKELDKNLKVCTSCDYHYKLNAVERIQMTMDEGMFVEYNADLASEDPLGFPDYGKKYAKAVESTGMQDAVITGEGTIGGYPVVVAVMSFDFMGGSLGSVVGEKVAIAVEKAIEKKCPMIIFSTSGGARMQESILSLMQMAKTSAALAKLSEQGGLYVSVITDPTFGGVSASFAMLGDYIIAEPGAAFGFTGRRVIEQTIKQKLPDNFQTSEFNLQHGQVDMVSHRKELRSTLSRLLGMHTIKEEIVHGK
>NC_015690.1|WP_013915001.1|1278426_1278618_+|hypothetical-protein
MWTVIYIAPTAKIADKIKQRLTEEGFLVQVRAINMTKNQFEIVVPEGELEEVQEVLNSILHRS
>NC_015690.1|WP_013915000.1|1277699_1278194_+|phosphatidylglycerophosphatase-A
MTKDPIIECLEKRGVTIDSIAEIVHQLQLPYNPALSKQACVDSVLTVLQKREVQYVLYTGIALDELAEKKLLPQPLQGLMETDASLYGVDETLALGIVHVYGMIGLTSFGYLDKKKIGIIRELNDHSTGIHVFLDDLVAGLAAAASARIAHRHQDELDGQDEGA
>NC_015690.1|WP_013915010.1|1290723_1291665_+|malate-dehydrogenase
MAIQRKKITVVGAGFTGATTALMLAQKELGDVVLLDIPQLENPTKGKALDMLEASPVQGFDAKIIGTSSYDDSASSDIVIITAGIARKPGMSRDDLVNTNAGIVKSVCENIKRTSPQSIVIILSNPVDAMTYVAFETLGFPKNRVIGQSGVLDTARYCTFIAQELNVSVEDVRGFVLGGHGDDMVPLVRYSNVGGIPIEKLIPADRIDAIVKRTRTGGGEIVNLLGNGSAYYAPAASLVQMTEAILKDKKRIIPAIALLQGEYGYDNLFMGVPTLLGGDGIEKVFELELLPEEKAALDKSAESVRNVTKVVTG
>NC_015690.1|WP_013915011.1|1291882_1292680_+|alpha/beta-hydrolase
MEPRSQSRARAKRSVWRLIASWMILLLLGLAAAGFVYLRPYEADDAARLAMMGSAGVEVAKEAHWLRFEPGSGETGGAAKPLPGVILYPGGLVQPESYAPLASRLAEEGYPVYIARMPLSLAVFGQNRAEELLQREPQGDFVIGGHSLGGSMAARFAAAHPDRLRGVFFLAAYADEGGSLRDAGLPVLSLVGTNDGVLNRERMEAGRAYVPGDASYLSMEGGNHAGFGSYGPQRGDGEAAILPEEQWERTVEALKNWAPLRKEAP
>NC_015690.1|WP_014369090.1|1293002_1293431_+|hypothetical-protein
MSQVFLYLHVLGAALMGFYLALPFLAARVEALPNGSAQHGFLSVLFSLNRAGQLALIIAFISGGYLVGKGGYPAIWWILAIVLLLAIGAVSGILGGKMRKALSDANGSSIKAQIGAIRTLSSVAGILYFLVITLMLFPNVFA
>NC_015690.1|WP_014369091.1|1293614_1294199_-|5'-deoxynucleotidase
MESHFFAYLYRLRFIERWSLMRNTMKENVAEHSFHVSLLTHVLCTIANEVYGRQVPTDKVVSMALFHDSTEVFTGDIPTPVKHHNPKILSNFREIEHLAAERLLDMVPEPLRRVYEPLIDPKKTTEDAELKKYIKAADSLDAYLKCVTELSAGNREFAVAKKQIEDTLQEMAMPEVDYFLKHLAPSLEKTLDEL
>NC_015690.1|WP_013915014.1|1294445_1295984_+|fumarate-hydratase
MQHFQESMYKLIVETSTNLPADVRQAIQAAREQEDAGTRSALSLSTIADNIQMAECNVSPICQDTGMPTFIVHCPVGANQIEMKKAIIAAVAQATKDSKLRTNSVDSLTGANSGDNIGPGTPVIHFEQWERDEIEAKLILKGGGCENKNIQYSLPAELEGLGKAGRDLDGIRKCILHAVYQAQGQGCSAGFIGVGIGGDRTTGYELAKHQLFRAADDVNPHPELRKLEEYVMENANKLGIGTMGFGGQVSLLGCKVGVMNRLPASFFVSVAYNCWAFRRQGVLIDANSGEITEWVYTKGETVPMQKDEPTAAAAAPSERREVVLQTPVSEEQIRQLKVGDVVIINGPMHTGRDALHKHLMDHDSPIDLNGAVIYHCGPVMAKDEQGGWVVKAAGPTTSIREEPYQGDIIKKFGIRAVIGKGGMGAKTLKALQEHGAVYLNAIGGAAQYYAQCFKKVEGVDFMEFGIPEAMWHLQTEGFAAIVTMDSHGNSLHADVEQESREKLAQFKEPVFS
>NC_015690.1|WP_013915015.1|1296011_1296989_+|bile-acid:sodium-symporter-family-protein
MRLNAVIEKYLSLIVPVSLILGFLLSRSFNGSAALVPYLFGYLTFVMATGCSWKQIREAFRMPVPMLLTFGLCHVLAPMIGYLIGTAAFGEGSPYVVGFVMFSVIPLGVSSVIWVGLSKGHVPLTLAMIVIDSALSPLVIPAAIEAFFGTTIAFDHTKVMMDLVQIIVVPTILGVLVNELSKGRFKGWSAPVCGPTSKLAMVIVVMINAAVIQPYVMEMKADMLTVVPLVFLLVAVSYALGFFGSLWLRKTDIIISVTYSSGMRNISLGLVLALAYFEPLTAVPVVLSILIQQPMASVNRWCMKLYGQSRLYKKITGAPQSGPLR
>NC_015690.1|WP_013915016.1|1297075_1298878_+|PAS-domain-S-box-protein
MKKFRARLTLIFIILIGSSVLTAGIFMARMLQQSYIESLTASMERELRVIKATTDWRQSGSEPELFRFYSDRAAMLRASADARLTFIRSDGKVLGDSDHDPALMENHLEREEIREASASKLYGSAIRYSSTVQRNLLYVAVPLLEGENVTGYLRMAMSLEDVEGSIRQVWFVLTGMLLAVFVIAGLISYRVAYSVTRPIELITSVARQITDMNYKYRVQVNKRDEIGQLGHAINRMADSLELQMNRISEDENRLKSVLESMTSGVIMIDREGKIALLNRSAEEILGFSAKELLGKSFNQAKQQYEFTQLIQECIDVRDHIRDEVIFYYPKERILEINLNPIAEAGGEWEGLLIVLHDITAVRRLERMRSEFVANVSHELKTPIAAVKGFAETLLAGALNDKETARSFLQIIFDESERLNRLIGDILELSKIESKRIPLQFSPVHLEPFIGNCVHVMNTEAKKKGIELELNVDGDFYMEADEDRLRQILINLLSNGISYTPEGGRVRLKVEQLVSGKEVTEHDKVRFTIADTGIGIPKKDLPRIFERFYRVDKARSRSSGGTGLGLSIVKHLVELHKGTIRVESEVGVGTKFIIEMPLIHN
>NC_015690.1|WP_014369094.1|1298987_1299710_+|response-regulator-transcription-factor
MPQKILVIEDEPTLARLLSYNLTQEGYETKVVDHGSDGLQAALQQYFDLIILDIMLPGMNGFEILSKLRQKGNKTPVIILTARNAEEEVVQGLKYGADDYITKPFGVAELLARVSAVLRRTMTEDGTQEKAGTGEKVISAGDLFIYPEKYEVLLGGESIPLRPKEFEVLLYLVQRPGVVVTRDDLMNIVWGFDYIGGQRTVDVHVSSLRKKLEMNQQSVQIESIRGVGYKLVTSMGALKK
>NC_015690.1|WP_049819028.1|1299746_1300820_+|Gfo/Idh/MocA-family-oxidoreductase
MLCPGSPVPGGAHVQFPGKSVEGRMRKNMEKIRWGVLGTGWIVNKAGQGILSSDNGVWLGAAGREPGRGQALAEKYGVPRAYDSYKELLADPEIDAVYIALLNHLHREWAVKACEAGKHVLLEKPFALNAVEASAIAEAAGRNGVRVREAFIWPFYPGIGEILQRLEQGAVGEWVRFRGHFSFRAFEDSTRWHRDWGGGALYDIGCYLVHWARSFTREEPQAAEAVWTIDERHGVDRRFCGTLHFAGGRTAQFDAALDMPHGSSFELLGTEGRLSAAFKAGPEKLRIECRIGEEEYIWETDRVTPFRRQAEAFAEEVLRMRTGEVISSDGGGEALRQAKAMDALREAARTGKRIVIG
>NC_015690.1|WP_013915019.1|1301046_1302129_+|Gfo/Idh/MocA-family-oxidoreductase
MSKVYRIGIIGCGGIANGKHMPALKNQPNAEMVAFCDIVEERAQEAKNAFGTPDAKVYTDYKELLADGALDIVHVCTPNDSHADISIFALESGKHVMCEKPMAKTAADARRMVEAAKRTGKKLTIGYQNRFRSDSQYLKRVCADGELGEIYYGKAHAIRRRAVPTWGVFLDEEKQGGGPLIDIGTHALDLTLWMMDNYKPKAVLGTAFHKLAKKADAANAWGSWDPEKFTVEDSAVGMITMQNGATIMLESSWAINLVKTGEAKTTLCGTEGGADMEDGLRINGEKHSKLFTNHIELDGRGVDFYEGSKDNPADLEAKLWLQAIENDTEPVVTPEQACVVSEILEAIYESSKTGKAVYFD

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Crispr_ID: NC_015690_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015690_7

1421715-1421789

Orphan

Consensus_repeat	Method
ATAGCGGAACTACGATTCGCTAATG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015690_7

>merge|NC_015690|7|1421715-1421789|CRISPRCasFinder
ATAGCGGAACTACGATTCGCTAATGTTAACCTGCCCTGGGCAGATAGGTGATAGCGGAACTACGATTCGCTATTG

>NC_015690|7|4|1421715-1421789|CRISPRCasFinder
ATAGCGGAACTACGATTCGCTAATG	TTAACCTGCCCTGGGCAGATAGGTG
ATAGCGGAACTACGATTCGCTATTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_015690.1\|WP_013915146.1\|1429050_1429548_+\|SRPBCC-domain-containing-protein	unknown	unknown	gnl\|CDD\|176856
NC_015690.1\|WP_014369170.1\|1414645_1415647_-\|DUF3231-family-protein	unknown	unknown	gnl\|CDD\|371599
NC_015690.1\|WP_013915138.1\|1425823_1426387_+\|ferredoxin	unknown	unknown	gnl\|CDD\|319891
NC_015690.1\|WP_013915135.1\|1421110_1421611_+\|hemerythrin-domain-containing-protein	unknown	unknown	gnl\|CDD\|376622
NC_015690.1\|WP_041616601.1\|1428481_1428988_+\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|176903
NC_015690.1\|WP_013915126.1\|1411081_1412395_+\|HupE/UreJ-family-protein	unknown	unknown	gnl\|CDD\|379373
NC_015690.1\|WP_013915136.1\|1422595_1423636_+\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013915125.1\|1409804_1411085_+\|DUF3500-domain-containing-protein	unknown	unknown	gnl\|CDD\|378789
NC_015690.1\|WP_013915131.1\|1418344_1419100_+\|pyruvate-formate-lyase-activating-protein	unknown	unknown	gnl\|CDD\|131546
NC_015690.1\|WP_013915133.1\|1420282_1420645_+\|DUF3147-family-protein	unknown	unknown	gnl\|CDD\|288237
NC_015690.1\|WP_041616599.1\|1426950_1427139_+\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013915127.1\|1412596_1413838_+\|NO-inducible-flavohemoprotein	unknown	unknown	gnl\|CDD\|237337
NC_015690.1\|WP_013915141.1\|1427157_1427505_+\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013915142.1\|1427491_1427818_+\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013915130.1\|1416007_1418272_+\|formate-C-acetyltransferase	unknown	unknown	gnl\|CDD\|153087
NC_015690.1\|WP_014369169.1\|1413961_1414486_-\|Crp/Fnr-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223736
NC_015690.1\|WP_013915137.1\|1423622_1425827_+\|molybdopterin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|239155
NC_015690.1\|WP_013915134.1\|1420661_1421030_+\|DUF3147-family-protein	unknown	unknown	gnl\|CDD\|288237
NC_015690.1\|WP_013915143.1\|1428064_1428322_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|373762
NC_015690.1\|WP_013915139.1\|1426424_1426961_+\|Rieske-2Fe-2S-domain-containing-protein	unknown	unknown	gnl\|CDD\|239558

Protein	Function_ID	Function_description	E-value
NC_015690.1\|WP_013915146.1\|1429050_1429548_+\|SRPBCC-domain-containing-protein	gnl\|CDD\|176856	cd07814, SRPBCC_CalC_Aha1-like, Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins. This family includes the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of Micromonospora echinospora CalC, human Aha1, and related proteins. Proteins in this group belong to the SRPBCC domain superfamily of proteins, which bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. MeCalC confers resistance to the enediyne, calicheamicin gamma 1 (CLM), by a self sacrificing mechanism which results in inactivation of both CalC and the highly reactive diradical enediyne species. MeCalC can also inactivate two other enediynes, shishijimicin and namenamicin. A crucial Gly of the MeCalC CLM resistance mechanism is not conserved in this subgroup. This family also includes the C-terminal, Bet v1-like domain of Aha1, one of several co-chaperones, which regulate the dimeric chaperone Hsp90. Aha1 promotes dimerization of the N-terminal domains of Hsp90, and stimulates its low intrinsic ATPase activity, and may regulate the dwell time of Hsp90 with client proteins. Aha1 can act as either a positive or negative regulator of chaperone-dependent activation, depending on the client protein, but the mechanisms by which these opposing functions are achieved are unclear. Aha1 is upregulated in a number of tumor lines co-incident with the activation of several signaling kinases.	8.53636e-30
NC_015690.1\|WP_014369170.1\|1414645_1415647_-\|DUF3231-family-protein	gnl\|CDD\|371599	pfam11553, DUF3231, Protein of unknown function (DUF3231). This bacterial family of proteins has no known function.	9.1823e-51
NC_015690.1\|WP_013915138.1\|1425823_1426387_+\|ferredoxin	gnl\|CDD\|319891	cd16369, DMSOR_beta_like, uncharacterized subfamily of DMSO Reductase beta subunit family. This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.	2.83993e-84
NC_015690.1\|WP_013915135.1\|1421110_1421611_+\|hemerythrin-domain-containing-protein	gnl\|CDD\|376622	pfam01814, Hemerythrin, Hemerythrin HHE cation binding domain. Iteration of the HHE family found it to be related to Hemerythrin. It also demonstrated that what has been described as a single domain in fact consists of two cation binding domains. Members of this family occur all across nature and are involved in a variety of processes. For instance, in Nereis diversicolor hemerythrin binds Cadmium so as to protect the organism from toxicity. However Hemerythrin is classically described as Oxygen-binding through two attached Fe2+ ions. And the bacterial NorA is a regulator of response to NO, which suggests yet another set-up for its metal ligands. In Staphylococcus aureus the iron-sulfur cluster repair protein ScdA has been noted to be important when the organism switches to living in environments with low oxygen concentrations; perhaps this protein acts as an oxygen store or scavenger.	0.000208048
NC_015690.1\|WP_041616601.1\|1428481_1428988_+\|SRPBCC-family-protein	gnl\|CDD\|176903	cd08894, SRPBCC_CalC_Aha1-like_1, Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins. SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.	5.64504e-69
NC_015690.1\|WP_013915126.1\|1411081_1412395_+\|HupE/UreJ-family-protein	gnl\|CDD\|379373	pfam13795, HupE_UreJ_2, HupE / UreJ protein. These proteins contain many conserved histidines that may be involved in nickel binding.	6.14967e-43
NC_015690.1\|WP_013915125.1\|1409804_1411085_+\|DUF3500-domain-containing-protein	gnl\|CDD\|378789	pfam12006, DUF3500, Protein of unknown function (DUF3500). This family of proteins is functionally uncharacterized. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 335 to 438 amino acids in length. This protein has a conserved GHH sequence motif. This protein has two completely conserved G residues that may be functionally important.	6.43794e-105
NC_015690.1\|WP_013915131.1\|1418344_1419100_+\|pyruvate-formate-lyase-activating-protein	gnl\|CDD\|131546	TIGR02493, PFLA, pyruvate formate-lyase 1-activating enzyme. An iron-sulfur protein with a radical-SAM domain (pfam04055). A single glycine residue in EC 2.3.1.54, formate C-acetyltransferase (formate-pyruvate lyase), is oxidized to the corresponding radical by transfer of H from its CH2 to AdoMet with concomitant cleavage of the latter. The reaction requires Fe2+. The first stage is reduction of the AdoMet to give methionine and the 5'-deoxyadenosin-5-yl radical, which then abstracts a hydrogen radical from the glycine residue. [Energy metabolism, Anaerobic, Protein fate, Protein modification and repair].	1.27286e-118
NC_015690.1\|WP_013915133.1\|1420282_1420645_+\|DUF3147-family-protein	gnl\|CDD\|288237	pfam11345, DUF3147, Protein of unknown function (DUF3147). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.	2.0056e-22
NC_015690.1\|WP_013915127.1\|1412596_1413838_+\|NO-inducible-flavohemoprotein	gnl\|CDD\|237337	PRK13289, PRK13289, NO-inducible flavohemoprotein.	0
NC_015690.1\|WP_013915130.1\|1416007_1418272_+\|formate-C-acetyltransferase	gnl\|CDD\|153087	cd01678, PFL1, Pyruvate formate lyase 1. Pyruvate formate lyase catalyzes a key step in anaerobic glycolysis, the conversion of pyruvate and CoenzymeA to formate and acetylCoA. The PFL mechanism involves an unusual radical cleavage of pyruvate in which two cysteines and one glycine form radicals that are required for catalysis. PFL has a ten-stranded alpha/beta barrel domain that is structurally similar to those of all three ribonucleotide reductase (RNR) classes as well as benzylsuccinate synthase and B12-independent glycerol dehydratase.	0
NC_015690.1\|WP_014369169.1\|1413961_1414486_-\|Crp/Fnr-family-transcriptional-regulator	gnl\|CDD\|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	1.26057e-22
NC_015690.1\|WP_013915137.1\|1423622_1425827_+\|molybdopterin-dependent-oxidoreductase	gnl\|CDD\|239155	cd02754, MopB_Nitrate-R-NapA-like, Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored tetraheme cytochrome. Members of the MopB_Nitrate-R-NapA CD belong to the molybdopterin_binding (MopB) superfamily of proteins.	0
NC_015690.1\|WP_013915134.1\|1420661_1421030_+\|DUF3147-family-protein	gnl\|CDD\|288237	pfam11345, DUF3147, Protein of unknown function (DUF3147). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.	3.59732e-21
NC_015690.1\|WP_013915143.1\|1428064_1428322_+\|hypothetical-protein	gnl\|CDD\|373762	pfam15336, Auts2, Autism susceptibility gene 2 protein. Auts2, or FBRSL2, Fibrosin-1-like protein 2, is a family of eukaryotic proteins associated both with a susceptibility to autism and with influencing the number of corpora lutea produced by breeding sows.	0.000977667
NC_015690.1\|WP_013915139.1\|1426424_1426961_+\|Rieske-2Fe-2S-domain-containing-protein	gnl\|CDD\|239558	cd03476, Rieske_ArOX_small, Small subunit of Arsenite oxidase (ArOX) family, Rieske domain; ArOX is a molybdenum/iron protein involved in the detoxification of arsenic, oxidizing it to arsenate. It consists of two subunits, a large subunit similar to members of the DMSO reductase family of molybdenum enzymes and a small subunit with a Rieske-type [2Fe-2S] cluster. The large subunit of ArOX contains the molybdenum site at which the oxidation of arsenite occurs. The small subunit contains a domain homologous to the Rieske domains of the cytochrome bc(1) and cytochrome b6f complexes as well as naphthalene 1,2-dioxygenase. The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer.	4.42785e-25

>NC_015690.1|WP_013915135.1|1421110_1421611_+|hemerythrin-domain-containing-protein
MTAYLGPAWRRLTEEHRSLGDMVYTLEAKVRTAGMDRGGRRSFPEWVLDDLHRSAAALRAELDLHSLWETKDLFPRLMELFPTPEGHIIVTSLWMLEKEHELADEYFDSFFREVGDLKAGRRGAALTRVLEDLMQAVRLVREHLEAEEDLLLPLMQESLQLAGEQG
>NC_015690.1|WP_013915134.1|1420661_1421030_+|DUF3147-family-protein
MTMSTNWKDLLLRFLLGGSAVVLSYAASVLLPWKALGGIFATFPAVMIVAVLMVGWAQGSARASEIARGSVYGMAGCAVCVVAVLYFMKTTGLWWLSLGLGLVCWYLSAFLIYKVRRSIKSS
>NC_015690.1|WP_013915133.1|1420282_1420645_+|DUF3147-family-protein
MVRLSLAALLLRFLFGGGAVVLASVLSKKLGGSVGGIFAAFPAVYLAALVAIRLDHTGNELVARSISLSQGALIGMGINILCAAAVGYLCAKRGWKRGLSLSIGGWFAVSLGVSYLLFSI
>NC_015690.1|WP_013915131.1|1418344_1419100_+|pyruvate-formate-lyase-activating-protein
MKGRIHSIDTFGTVDGPGIRFVLFMQGCALQCGFCHNPDTWDPNRGRCVTVDEVLAEIEPYLEYYRRSGGGITVTGGEPTLQAPFVAELFKECKRRWGLHTTLDSSGYCQPDHVEELMSVTDLVLLDLKQMDDAKHRALTSQSNERILRFAAWLSEREQPVWIRHVLVPGITDDYADLTALGRFIGGLSRVEKVEILPYHRMGVYKWQQLGRDYPLEGVPTPDDREVQRTYRLLEEGRAQRARESGQAVSL
>NC_015690.1|WP_013915130.1|1416007_1418272_+|formate-C-acetyltransferase
MAMKEAEVSQGRAAGWREFRGGAWQQEINVKDFIDLNLTPYHGDHSFLAGPTDATNALWAKVRELMVQERANGGVLDVDVNTVSTITSHAPGYIDQAKEQIVGLQTDAPLKRSVQPFGGIRMVQDACEAYGYKLPEEIVRLFTDIRKTHNQGVFDAYTTAMKTARKAGIITGLPDAYGRGRIIGDYRRVALYGVDRLIEDKKNELQRLEAGAMIEEVIRDREELSEQILSLRQLKAMAASYGYDISAPASSAKEAVQWLYFAYLAAIKEQNGAAMSLGRVSSFLDIYIERDLRSGELTEEAAQELMDHFVMKLRLVKFLRTPDYNELFSGDPTWVTESVGGMGENGQTKVTRSSFRILHTLYNLGPAPEPNLTVLWSTELPQGFKSYCAKVSIETSSIQYENDDLMRPHFGDDYGIACCVSAMRIGKQMQFFGARANLAKALLYAINGGVDEKLGIQVAPAAAPITSEVLGYEEVRARFDATMDWLAELYMNTLNVIHYMHDKYSYERLEMALHDREILRTMACGIAGLSVVADSLSAIKHAKVKPIRNEWGTAVDFEIEGEYPQYGNNDERVDAIAVELAETFMNKLRKHRTYRNALPTMSVLTITSNVVYGKKTGTTPDGRKAGEPFAPGANPMHGRDRKGALASLASVAKIPYDSCLDGISNTFSIIPKALGKEEEARVSNMVSLLDGYAATRGHHLNVNVFDREQLLDAMEHPENYPQLTIRVSGYAVNFIKLTREQQLDVINRTFHGRV
>NC_015690.1|WP_014369170.1|1414645_1415647_-|DUF3231-family-protein
MQKHPIKLTSGEIAPLWTGYLGDSMANCVLHYFLRKVEDEEVRPILEYALSLTNEHMAFKDKLFRNEDFPIPRAFTGEDVNPDAPRLFSDTFTLLYLRQMGTGGMTAYGLALASSTREDIRAFFNHNLKTAAELYNKATTLLLEKGLLPRVPHITYPRTAEFVQKEGWLNGLLGDRRTLNAAEITHLHLNILTNRIGQTLMQAFAQCVRSKDVIPHIVRGMRIATKHIEVFSSLLRDDHLPAPETWEAEVTDSVESPFSDKLMLHHTLSLSALGLSNYGAAVAGSMRRDLATVYIRLAAEVGTYADDGAELMIRKEWLEKMPGAIERDALIQA
>NC_015690.1|WP_014369169.1|1413961_1414486_-|Crp/Fnr-family-transcriptional-regulator
MILHKGETLFRQGEQGPLYHLKSGLLKIIRVHEDGHALLVNIIVPGEIIPHHSLISPNPYYGTAVALVTCEIEVLPAADWYGGLESDPAKYRSTAKLLQDKLRMMQQRIDQLTETAPAAKLQKLQTWFERYLGPGKLTDVLTQDEIGQFIGLRRETVNRLLRAQAAEAAGGPKD
>NC_015690.1|WP_013915127.1|1412596_1413838_+|NO-inducible-flavohemoprotein
MLSQPTIDIIKSTVPVLEVHGTAITRRFYERMFSRHPELLHIFNHANQKQGRQQTALANAVYAAAQNIDKLETILPVVKGIAHKHRSLGVRPEHYGIVGENLLAAIAEVLGDAATEEILEAWKEAYGVIADVFIGVEANMYAAAEAGEGGWAGFRAFRVQRKVRESEVISSFYLVPEDGRKLAEFEPGQYVSVRLDIPGEAHTHIRQYSLSDAPGRPYYRISVKREDAAGDRPAGKVSLYLHEQVTEGSVLWLSAPAGDFELNRHSDEPVVLISGGVGLTPMVSMLHTLAEKQPHRQVTFIHAAQNGDVHALREEVEGLAAGHEQISVHWCYEKPTERDRAGNRFHQEGYIDLAWLRSVVPGAGADFYFCGPVPFMSAVNGILEAWGVPASRIHYEFFGPAGSLKGAAAPVHP
>NC_015690.1|WP_013915126.1|1411081_1412395_+|HupE/UreJ-family-protein
MRAGRNLILLCLSLVVMTVLTVLPAGPASAHAMPSSAVYLDVHEDGVEAELQLPLDRLEVAFGQTLTANPEDVPASYGRELSAYAADRIQPQTPEGEAWTVEVRSLEVQAEEQGSELIVKVWLQPPAGASVEKFTLNYDVIIRELLTHTILVSVRSDWKSGITAADPELIGTIQGKVQSLDVDRSGGSLWTGFQSVVASGMHHIAEGFDHLLFLLVLLLPAPLAVRGGRWDGFAGARHSVMGLLKVVTAFTFGHSFTLIAGALGWIPFPERTVEILIAVSILVSAIHALRPLFPGREVLVAGSFGLVHGMAFAALITELSMTSWQKALSILGFNLGIELMQLFVIAITVPWLILLSLTRAYHPVRTAGAVFAGIAALGWMAERALGTSNKAAALADAAGGHALWLVAALACIAVMGFTWSWFRKNGELKRGAVPSLK
>NC_015690.1|WP_013915125.1|1409804_1411085_+|DUF3500-domain-containing-protein
MKRKKETKTILMAVAMSLVMSACANGAISTTAGSGSTTADTTAAASTAEGTTAAPANAGPGGGPPPDGQGGPGGGPGGPGGEAVDTTTGRVTDVAAAVKADAVTGSTACSSSTETDAAVACLADAFLKTLTDEQKEAVQFDLTAENGAVWSNLPAGNVKRNGLMFGTLSTESLEAVKALAAEALSGTGYSTLRSIILADEYLTTDTGNTMWDADLYYIAFLGTPSATEPWVLQISGHHYAANLSFNMKTDSVTPMFVGVEPQTFTMDGVTYEPLAARRDAMYNMLGSLSAEQQKTATISGKFDDVLVGPGQDGNFPAKEEGILYTELDDSQKALVKASIEAWVKDANEELSQELLSAYLSEEALSQTYIGWSGSTSYADHGSYIRISGPRVWIEFVCQTGVAYKDQIHFHTIWRDKLADYGGSFSS
>NC_015690.1|WP_013915136.1|1422595_1423636_+|hypothetical-protein
MNRAFASRWARNVFITICGLIILMYLGSRLFTHIDLALYGYMVGTVVFIGGFFYRFMAWADRPPTRLILTKGLRLLFRRSTPQTAADHLVVYKFIWNRGWYRWAQHILLGWGCILSAFVTFPLVFGWMYFTMENNGYYTVVGFGIDLMKVKADGILAFLFYNALNFTAMMVIAGVCMALYRRLKNMQARAEQSFVYDFLPLYLLLFISVTGLLLTFSNVFLHGWGHPVMSMIHQWSVIVTLIYLPFGKLAHIPFRPMSVLARNYREHYGQQAPKACRVCAANYVSAEQAQDVMNVLKSNGMEFTTPEGYQLAELCLPCRRKYRMSRFSGVPTHEIRVKEANQNAKG
>NC_015690.1|WP_013915137.1|1423622_1425827_+|molybdopterin-dependent-oxidoreductase
MPKDKFFKVIENRTHPGEKLVDTHCSYCGMQCGMKLRVDTSTNRIIGVEPRYDWPVTLGKMCPKGVTAYQQTNHDDRLLKPLIRDDRSLRGTKMGFREATWEEAYELIVRKFQELQSGFGKDSLSVFSGVSMTNEKCYLTGKFARVALQTRYIDYNGRFCMSSAAAGFMRTFGVDRGSTLPWTDLHETDCLFIAGSNTAECHPTSMFRVWEVQNRGGYLIVADPRETPIARRADVHLDLRPGTDLALANCMVNLLIQGGYADREFVEKHTNGFDAMLEVVKQFTPEYTSEITGVATEKLIRAAEIYGKAPNAVVMFARGIEQQHKGVDNVSAYTNMSLVTGKIGRPKSGVATFTGQGNGQGGREHGQKADALPGYRKIANPKHVEEVCKVWGITPEEMPQPGVSAYEMFGLMQDKTIRGLYLLCSNPAVSAPNLNEVRAALMNLDFMVCCDMFLSESAEFADVVLPTVTWSEDEGTVTNLEGRIIKINKAQEPLGESKPDWEIQVELAERLGRGQYFRHLKTARDINDEFRLASKGGYADYYGATWEKIEEQQGVFWPCRDEADPGTPHMFLDKKFYHPDGKALLCALPYRPPAEEPCGDYPLRMTTGRVVYHYLSGNQTRRIPFLRDMCPEPFVEVHPETAKRYGIAHEEMVRVRTRRGEAEFKVKITEAIRRDTVFVPYHFGHEKSVNLLTIAALDPTSKMPEFKACAAEIEKLTAAPAAQAQEPIKEVIQT
>NC_015690.1|WP_013915138.1|1425823_1426387_+|ferredoxin
MKQHLYIEMDNCIGCRSCLAACTQCGGHDERNRNYVYDVNPLVNRQTIPLMCLHCVNPACARSCPAQAIQVTPEGAVLSALVEKCIGCQNCTIACPYGIPKFDEEQNLMYKCDLCYDRTKDGIPPMCASVCPTNTLQWLTEDELKAKRESHELGRWTASCLPDDPLVGETNVKISLPGILQGKVKLF
>NC_015690.1|WP_013915139.1|1426424_1426961_+|Rieske-2Fe-2S-domain-containing-protein
MNGDQTRGNGAVPPHEDNYTHNIRKDNERRLDRRSFMKTMVGAAGVFAVSTLPWGAIAAKELSSPAKKAFPKTRITALSDLKVGEAVEFAYPGEHDSALLVRLGEGEFKAYQNACTHLKCPVFWSGEKGELVCPCHHGLFDVRTGAPVAGPPKRPLPEIELKLEQGTVYAVGVKRYET
>NC_015690.1|WP_041616599.1|1426950_1427139_+|hypothetical-protein
MKRSWLGVILLSLVLLLSIVFTQQVVNAFFYEKYARVLLFAGGNVLLFPLSLWIYKREKDRA
>NC_015690.1|WP_013915141.1|1427157_1427505_+|hypothetical-protein
MPSEYDAALCFVRTPDREGRPLQEELAADLHGIFPGASLDLEPKSEDGFEIVVARMNGLGPWGSEEELLGRMEREMPESWWTWLAGYRLLVTPKEDAGPCRLKNNRKEARTHECQ
>NC_015690.1|WP_013915142.1|1427491_1427818_+|hypothetical-protein
MNASKDKLSEVIRDLEQAVKGLCGRQVEIRIEDTMEGDTQAPPRTFELVRAVMVPEGTHLKCYLNLTQHISIPVFADGRTCLEVEGPGGTRLISVDLQSGLRYRLRWL
>NC_015690.1|WP_013915143.1|1428064_1428322_+|hypothetical-protein
MREREREREREREREDGPLDPEELKQVLTEALEQENELLRTYVIASERIEDNEELRVRLQNFAEGNAKRSRQLIEELGAMKDADE
>NC_015690.1|WP_041616601.1|1428481_1428988_+|SRPBCC-family-protein
MVHIGANGCTETSVNGREIVVNRTLAAPRELVFQTWTDPAHLPHWWGPKGFTITVQEIDVRPGGEWRYIMHGPDGTDYENRILYREVVHPEKLVYSHGDGGEEESFRVTVTFAEQGEETRLTMRMLFNSAEELKQAVEEYGAVEGAGSTLDRLEERLADVISEQAKQA
>NC_015690.1|WP_013915146.1|1429050_1429548_+|SRPBCC-domain-containing-protein
MSHIVDLIITRTIQAPREIVFQAFTQAEHLKHWWGPKGWVMDVSQIEVRPGGICHYRLQSAEGHVMWAKFVYSEISTPEKLVYISSFSDEDGRTVRAPFSPAFPLEVRNTLTLTELDGRTTFTLHGEPVSATEEEHEFFRSMHESMQMGFGGTFDQLAEYLASKR

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Crispr_ID: NC_015690_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015690_8

1475347-1475443

Orphan

Consensus_repeat	Method
TCATTTTGTAAGCGACCTTTGTGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015690_8

>merge|NC_015690|8|1475347-1475443|CRISPRCasFinder
TCATTTTGTAAGCGACCTTTGTGCGGAGTGCAAAGAGTAGCAGTCTAATAATTAAATACCAGCGAGGATCTATCATTTTGAAAGCGACCTTTGTGCG

>NC_015690|8|5|1475347-1475443|CRISPRCasFinder
TCATTTTGTAAGCGACCTTTGTGCG	GAGTGCAAAGAGTAGCAGTCTAATAATTAAATACCAGCGAGGATCTA
TCATTTTGAAAGCGACCTTTGTGCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_015690.1\|WP_013915184.1\|1473171_1474677_+\|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl\|CDD\|214599
NC_015690.1\|WP_013915191.1\|1483292_1483970_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_015690.1\|WP_013915175.1\|1462288_1464115_-\|APC-family-permease	unknown	unknown	gnl\|CDD\|372624
NC_015690.1\|WP_013915187.1\|1477727_1478345_+\|DedA-family-protein	unknown	unknown	gnl\|CDD\|223659
NC_015690.1\|WP_013915177.1\|1464683_1466336_-\|family-14-glycosylhydrolase	unknown	unknown	gnl\|CDD\|366599
NC_015690.1\|WP_013915190.1\|1480777_1482436_+\|right-handed-parallel-beta-helix-repeat-containing-protein	unknown	unknown	gnl\|CDD\|378931
NC_015690.1\|WP_013915188.1\|1478645_1479779_+\|acyltransferase-family-protein	unknown	unknown	gnl\|CDD\|226446
NC_015690.1\|WP_013915181.1\|1470343_1471465_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226962
NC_015690.1\|WP_013915180.1\|1468799_1470347_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226364
NC_015690.1\|WP_013915192.1\|1483966_1485349_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|274368
NC_015690.1\|WP_013915174.1\|1461118_1462063_-\|EamA-family-transporter	unknown	unknown	gnl\|CDD\|273359
NC_015690.1\|WP_013915183.1\|1472478_1472964_+\|nucleoside-deaminase	unknown	unknown	gnl\|CDD\|238612
NC_015690.1\|WP_143768107.1\|1476545_1477520_+\|carbohydrate-kinase	unknown	unknown	gnl\|CDD\|238572
NC_015690.1\|WP_041616610.1\|1466584_1466746_+\|XapX-domain-containing-protein	unknown	unknown	gnl\|CDD\|274620
NC_015690.1\|WP_013915193.1\|1485470_1489268_+\|S-layer-homology-domain-containing-protein	unknown	unknown	gnl\|CDD\|336728
NC_015690.1\|WP_013915197.1\|1491521_1494107_+\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|236645
NC_015690.1\|WP_013915182.1\|1471481_1472411_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224005
NC_015690.1\|WP_013915185.1\|1475523_1476507_+\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_015690.1\|WP_013915189.1\|1480029_1480419_-\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_041616611.1\|1467505_1468657_+\|BMP-family-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380618

Protein	Function_ID	Function_description	E-value
NC_015690.1\|WP_013915184.1\|1473171_1474677_+\|methyl-accepting-chemotaxis-protein	gnl\|CDD\|214599	smart00283, MA, Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.	1.7257e-49
NC_015690.1\|WP_013915191.1\|1483292_1483970_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	3.16891e-83
NC_015690.1\|WP_013915175.1\|1462288_1464115_-\|APC-family-permease	gnl\|CDD\|372624	pfam13520, AA_permease_2, Amino acid permease.	4.56969e-29
NC_015690.1\|WP_013915187.1\|1477727_1478345_+\|DedA-family-protein	gnl\|CDD\|223659	COG0586, DedA, Uncharacterized membrane-associated protein [Function unknown].	1.86883e-29
NC_015690.1\|WP_013915177.1\|1464683_1466336_-\|family-14-glycosylhydrolase	gnl\|CDD\|366599	pfam01373, Glyco_hydro_14, Glycosyl hydrolase family 14. This family are beta amylases.	0
NC_015690.1\|WP_013915190.1\|1480777_1482436_+\|right-handed-parallel-beta-helix-repeat-containing-protein	gnl\|CDD\|378931	pfam12708, Pectate_lyase_3, Pectate lyase superfamily protein. This family of proteins possesses a beta helical structure like Pectate lyase. This family is most closely related to glycosyl hydrolase family 28.	6.24125e-06
NC_015690.1\|WP_013915188.1\|1478645_1479779_+\|acyltransferase-family-protein	gnl\|CDD\|226446	COG3936, COG3936, Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism].	1.02645e-40
NC_015690.1\|WP_013915181.1\|1470343_1471465_+\|ABC-transporter-permease	gnl\|CDD\|226962	COG4603, COG4603, ABC-type uncharacterized transport system, permease component [General function prediction only].	1.94763e-105
NC_015690.1\|WP_013915180.1\|1468799_1470347_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|226364	COG3845, COG3845, ABC-type uncharacterized transport systems, ATPase components [General function prediction only].	0
NC_015690.1\|WP_013915192.1\|1483966_1485349_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|274368	TIGR02966, Phosphate_regulon_sensor_protein_PhoR, phosphate regulon sensor kinase PhoR. Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems].	7.8518e-70
NC_015690.1\|WP_013915174.1\|1461118_1462063_-\|EamA-family-transporter	gnl\|CDD\|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	2.23701e-17
NC_015690.1\|WP_013915183.1\|1472478_1472964_+\|nucleoside-deaminase	gnl\|CDD\|238612	cd01285, nucleoside_deaminase, Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on the substrate. The functional enzyme is a homodimer. Cytosine deaminase catalyzes the deamination of cytosine to uracil and ammonia and is a member of the pyrimidine salvage pathway. Cytosine deaminase is found in bacteria and fungi but is not present in mammals; for this reason, the enzyme is currently of interest for antimicrobial drug design and gene therapy applications against tumors. Some members of this family are tRNA-specific adenosine deaminases that generate inosine at the first position of their anticodon (position 34) of specific tRNAs; this modification is thought to enlarge the codon recognition capacity during protein synthesis. Other members of the family are guanine deaminases which deaminate guanine to xanthine as part of the utilization of guanine as a nitrogen source.	3.34725e-33
NC_015690.1\|WP_143768107.1\|1476545_1477520_+\|carbohydrate-kinase	gnl\|CDD\|238572	cd01167, bac_FRK, Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into glucose-6-phosphate. This is in contrast to FRKs [or ketohexokinases (KHKs)] from mammalia and halophilic archaebacteria, which phosphorylate fructose to fructose-1-phosphate.	2.2786e-106
NC_015690.1\|WP_041616610.1\|1466584_1466746_+\|XapX-domain-containing-protein	gnl\|CDD\|274620	TIGR03510, conserved_hypothetical_protein, XapX domain. This model describes an uncharacterized small, hydrophobic protein of about 50 amino acids, found between the xapB and xapR genes of the E. coli xanthosine utilization system, and homologous regions in other small proteins, such as the N-terminal region of DUF1427 (pfam07235). We name this domain XapX, as it comprises the full length of the protein encoded between the genes for the well-studied XapB and XapR proteins. [Unknown function, General].	6.71793e-06
NC_015690.1\|WP_013915193.1\|1485470_1489268_+\|S-layer-homology-domain-containing-protein	gnl\|CDD\|336728	pfam07532, Big_4, Bacterial Ig-like domain (group 4). This family consists of bacterial domains with an Ig-like fold. Members of this family are found in a variety of bacterial surface proteins.	7.33119e-11
NC_015690.1\|WP_013915197.1\|1491521_1494107_+\|EAL-domain-containing-protein	gnl\|CDD\|236645	PRK10060, PRK10060, cyclic di-GMP phosphodiesterase.	4.42524e-114
NC_015690.1\|WP_013915182.1\|1471481_1472411_+\|ABC-transporter-permease	gnl\|CDD\|224005	COG1079, COG1079, Uncharacterized ABC-type transport system, permease component [General function prediction only].	7.85145e-93
NC_015690.1\|WP_013915185.1\|1475523_1476507_+\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	8.59934e-123
NC_015690.1\|WP_041616611.1\|1467505_1468657_+\|BMP-family-ABC-transporter-substrate-binding-protein	gnl\|CDD\|380618	cd19963, PBP1_BMP-like, periplasmic binding component of a basic membrane lipoprotein (BMP) from Brucella abortus and its close homologs in other bacteria. Periplasmic binding component of a family of basic membrane lipoproteins from Borrelia and various putative lipoproteins from other bacteria. These outer membrane proteins include Med, a cell-surface localized protein regulating the competence transcription factor gene comK in Bacillus subtilis, and PnrA, a periplasmic purine nucleoside binding protein of an ATP-binding cassette (ABC) transport system in Treponema pallidum. All contain the type 1 periplasmic sugar-binding protein-like fold.	1.6767e-154

>NC_015690.1|WP_013915184.1|1473171_1474677_+|methyl-accepting-chemotaxis-protein
MGVTSQQIPEPTAAPRVLNEIEGVYLTRNKIMAWLFAGLFALNAVTVLITRGWGFLPLTLLLGATSGILFYAVNKRAGLTKVPFVVVACFLLLHLILLGIEFSAVNTLILAIFLCLFPSYRYVLTFSVLALVEMNVLSAVTGKLPVGDNLVLHNILLVIALVPLVIMALLSQRLLRSMLVQMKEAEQASLQVSTMFDKVKQAVGILGEFSKELQENSTTTGQITREVSIGFSEIMKGVETQAASVSDISEQLGGSHADIAAVAGSANEMKEISRQTASVTAGGTEQVHDMAVRIQEVERIMDTIVDSMEKLNAQNAAIGTILSSITEIANQTNLLSLNASIEAARAGEQGRGFAVVANEVKKLAESSQKSAEEISGILGSIQGSFTSLTEQVGRGKQALGTSKESAKQSETIFSQIADFTQQVVAQASEVEQKTLKIKTSSDHIVQEVSSIAAVTEESTAAFEEISASVENQKQMVERTVASFRQLEELIVDLNKMVSGQE
>NC_015690.1|WP_013915183.1|1472478_1472964_+|nucleoside-deaminase
MTDREKHIPYLRRCVELSLLARESGNTPFGALLAGPDGTILLEQGNIEITGRNCTGHAERTLMEAASKRFSRQELWNCTLYTSAEPCAMCAGSIYWGNVGRVVYGISEKHLAELTGEDEQNPTLDLPCREVFSRGRKPIEVIGPFPEVEEETAAAHAGYWK
>NC_015690.1|WP_013915182.1|1471481_1472411_+|ABC-transporter-permease
MELMTQIIAAAMASGTPLLIAALGGILIERSGITQLGAEGLMLMGAVTSCIVFIQTGSLTLALLAVLAVSAVLGLVHGVLCVTLRANQVVSGLAMTLFGTGLSAYLGKPVSGQPLPGAVPKLDLPSLQGIPVIGPLFGHLDLFTYLSFALVLALHLFIHRTSWGLSLRAVGDNPATADVMGIPVLGLRYACIVIGTMMIGLAGADLLLVYTPAWNEGMTAGRGWIAVALIIFARWNPVRALVCAYFFGALDTLGLRIQLTGIEIPSYFLKMIPYLVTVAVLMFLGWRSRGKPSGAPEALGLPYIREQRF
>NC_015690.1|WP_013915181.1|1470343_1471465_+|ABC-transporter-permease
MNERHTAPSLQLEQGRGARRSRFRLPYRIEIDPAGGQGPWWVPVVSIVLALAVCGIFIAWNGMNPLTVYAKMVKGAFGTSFGFTETLVKAIPLMLCGLGVSIAYRISVWNIGAEGQFIAGAMAATAVTVYYPELPMVLSIPFMLLASLAAGGLWGLLTAIPRTYFGVNELITSLMLNYVALLALNYVVFGPWKDPKGFNFPGTPMFTEAQSLPVLGATRLHMGLVFALAGVLLYWLVIRYTRWGYELRLIGANAEAARNAGIPISRHILAVMLVSGALAGLAGMSEVAGVTHRLMYGISPGYGYTAVIVAWLAKLNPAGLVISSVLFGGLIVGGYSVQTIGLPSSISSMLQGAILFFLIAGAMAGKFRLRRSR
>NC_015690.1|WP_013915180.1|1468799_1470347_+|ABC-transporter-ATP-binding-protein
MGSSVFSVEMKGIVKQFGSVTANDHVDFRAKPGEIHALLGENGAGKSTMMCMLSGVYRPTSGEIYIRGKAAGIRSPKDAMRLGVGMVFQNFRLVQTLTAAENIVLGERSGFWRGPGWIRRKQEEIEAISERFGLPFPADRPVWQLSVGEQQRVEIVKTLYRGADLIILDEPTSVLTPGEVDQLFETLARMKSEGKTVIMTTHKLKEVMFASDRISVMRKGRMIAEMEKRETSEGELAQLMVGSRTAPQPAAKLQGSPKAGGPLLVVRGLDVYGDHGRKALGGLGFEVREGEIVGVAGVSGNGQKELAEVLTGLRMWKGGSVEFAGRPLKNGSVRAAIESGIAHVPENRMKSGLAGSLGSVDNLLFKTYRSPKRSRLGILRSGSNRSWAAELVERYDVKTPGIDAPVQMMSGGNQQKLLFAREIEQDPKLMVAVHPTQGLDVGASQGVHRLLGELRSRGRGVLLISEDLDEVLQLSDRVLVLYGGRNVGTVDRAEADRERIGRLMAGLTEREGEAG
>NC_015690.1|WP_041616611.1|1467505_1468657_+|BMP-family-ABC-transporter-substrate-binding-protein
MNRRRRSGVIGLVLTMVMAWALAGCSGGGASTGAGGTADPKSTEPAPTTDTGSKTPRVAFVYIGPPGDGGWTFQHDEGRKQMEKELGIKADTVENVPESADAERVITELAQNHDIVFTTSFGYMDYTLNVAKKFQNVKFEHTAGYKTHANMSTYFGKNFEASYLSGIAAGKMTKKNLIGYVGAFPIPEVIYNINAFTLGIQSVNPDAKVQVVWTNTWYDPTTERQAAVSLLDKGADVLLAYQDSPATLQAAAERGAMAGGNDSDMSRFAPKAYLTNPIWNWGPYYTKTVKSVMDGTWKSQQYMGSMADGMVGLAPLGESVPDDVKKLVEDAKAKILSGELKVYQGPIKDAGGTVKVEAGKELPLSDILQMNWFVQGVEGTIPK
>NC_015690.1|WP_041616610.1|1466584_1466746_+|XapX-domain-containing-protein
MMEAVLSLLAGMVVGVLFTFIRLPLPAPVTIAGVLGVAGVYLGGKLVSLFIRS
>NC_015690.1|WP_013915177.1|1464683_1466336_-|family-14-glycosylhydrolase
MAITTVSTSVLLRKSSAALLSLVVGAGLLAPIPSAEASSISSDYKTYVMAPLTKITDWNAFRNQLITLKNNNVYAVTTDVWWGDVEGAGDNVFDWSYYKTYADTVRAAGLKWVPILSTHQCGGNVGDDCDIKLPNWLWSKGTQDQLTIRSETGFYNKETLSPWWSGTAAQYDELYASFASNFSGYKDIIAKIYLSGGPAGELRFPSYNTADGWSYPSRGKLQAYTDSAKADFRTAMQTKYGTVGALNTAWGTSLASFSDVSPPSDGDNFFTNGYKSNYGKDFLTWYQGVLEKHVKAIGAKAHSRFDSVFGVPVGAKISGVHWQMNNPTMPHSAEYGAGYYNYSTLLDAFKSANLDLTFTCLEMTDAQANTAPYYSAPKSLVIQVSNLANQKGIRLNGENALAIGDAGQYQNVAEMLFNYNFSGFTLLRMSSLVNASGTATSLMSSFRDALAMTPTAVTFVVKGAPTASGDTVYVTGSRWEMGNWTTGVYPLKLTYNSTTADWRGTAYIGSGRNYEFKAIVKNSAGAVTWEPGSNNTLTVPSAASTYTITW
>NC_015690.1|WP_013915175.1|1462288_1464115_-|APC-family-permease
MFASIKRFLIGRPLKSNELGEQKLNKLKALAILSSDALSSVAYGPEQILLVLMTVGAVAFWYSIPIAVGVLILLTALILSYRQIIFAYPHGGGAYVVSKQNLGIYPGLIAGGSLLVDYILTVAVSVSAGTDAITSAFPALHDHTVLIAVAFVIFITLLNLRGVTESASVLAYPVYLFVLALFILIGAGLYNIISGRGPSGVHAPLGTPVAGVGLFLLLRAFASGSSALTGVEAISNAIPNFEDPAPKNAAKTLTAMGLLLGLLFSGIVFLAYYYGITPRPEVTVVSEIAEATFGRNFMYYFIQGTTALILILAANTGYSAFPLLAVNLAQDKFIPRMFTVRGDRLGYSNGIIILGVLSILLIIVFKGQTEHLIPLYAVGVFIPFTLSQTGMMMKWIREKPQGWALKLTINSAGALISLLVTIMFFLTKFSQVWTVLVFLPLIILLFHRIRKHYEAVGDQLRLTTCEPALTIEGNVMILPVAGMTHVVENSLNYVKSLAPQQIIAVHVPFEREDEAEFEAKWKKWQPDIRLVTLHSPYRSIIQPLTKFIDTVQRKAGESNYQVTVVIPQFIPKKGWHNILHNQSSLLIRAHLLYRRNVIVTTVPYHLKK
>NC_015690.1|WP_013915174.1|1461118_1462063_-|EamA-family-transporter
MPHQTNSSADSHPSPASLASSKGALYHMIAAMAIFGSVGFAAGRTGLQSFELVFVRCICAVPILGTGWLLSGQFRREAWPVREVLLVLLSGLCLVGNWVFLFRAFEAMPVTVAVSVYYLAPVFVLLLGSLLFRERLKVSSAVSVAVCAAGTALVSGIGSGAPGEVLSGGLLWALLAALLYALVTLLGKGIRRMSPYALAMLQTAVGVLLLPPLVHFAAFGGLGSSQSLWIALIGAVHTGLVYYLFFGSLRHLPARTISLLAFLDPGIAMLLDMLITGFRPGLLQIVGIVLLFGGMTVPLWDRKDRAAQPSALTE
>NC_015690.1|WP_013915185.1|1475523_1476507_+|LacI-family-DNA-binding-transcriptional-regulator
MAERAGVSTATVSHVINGTRFVSEEAKAKVNRAMEELEYRPNTLARGLRSQKSMTVGLIVPILPSDTSNFFFLTVAQGIQKVLREHGYQLLLSSNMSGTPEEEREQIRLLQSKWIDGLIIAPAAGGTGFPLEPGEDGLSVVFIDRQPQGVSGDCVLGDSFGGAYEAVSLLLEQGHRRIGYIAGEEGITTSSERYEGYRQALADRGLTPDPLLEKSAASSFESGYACAKELLGAGGVTALFVANNVQTMGAMKYIQERGFRVPGELAIIGFDDYDWTRVTTPPLTVIRQPAFELGCRAAEVLLERIGQPDRPPQEYRLKAELIRRDSC
>NC_015690.1|WP_143768107.1|1476545_1477520_+|carbohydrate-kinase
MIMNWDVTALGEVLIDMTPAGTSDKGYPLYESNPGGAPANVLAALSKLGKRTAFIGKVGADGFGTYLRDTLQECEIDTSGLIFTEEANTTMAFVHLSADGDRSFSFFRKPGADRLLEAGEVRGELLAQSRIFHFGSISMTHEPSAEATRFAVSGAKAAGALISYDPNLRMPLWSDAAHAKAMMEYGLGCADVVKISEEELEFLTGLTDLADGSQQLAERFGIPLILVTLAEKGSFYRFGGATGLVPGYAVNTVDTTGAGDAFLGGVLYGLLEKDRRLSELQEEEVRQVVTFANAVGALATTVKGAIPAMPDLAAIRRLMDSVVS
>NC_015690.1|WP_013915187.1|1477727_1478345_+|DedA-family-protein
MTVDTLVAWIEQFGYAALFFSLWLGIVGAPIPDEAIVMTGGAVTAGGLLQPVPAFLLTYLGVVSGLSLGYVLGRYAGGWAVDKLRSKPKLQKHILFSERLVERYGSLALVISYFVPVVRHVMPYLLGMNRMPFSRYAALSYSTGLLWTMLFFLLGRYAGDHADEAVSYLYGYGIKLLWLPCVLAAGLWAVRSVMRRRRLQREDSL
>NC_015690.1|WP_013915188.1|1478645_1479779_+|acyltransferase-family-protein
MSGKKLSYEILLLRCIGCLFVAAVHAVIMTYRIHDPIPNELYRLALNSIRTICSVGTPIFIFITEFLIAKNYKEDLPKQFISKRLKVLIPPYIAMGIIGSLYKVQESGQPFTAYNLGMQSLKNIFLADYNGYFIVIIIQFILIHYLFHYKLKLWPAKIVLPASFLVNFVYLAFFNFVPPFGFSESTGNYIWYYLSWMPFFGWAFYFALGYYCGKHYDKFIETLNRRKWLILAAPLFFGAVLLGTKMLGIPKVNTSKTIWYLFFMPSVTFVIFYLSSKLKSVPNFVVSISDHSFGIYLTHAVIMRVFVLLYKPHFADAPAIVTFVLIYVTCVGLAMAVTNVLNKVPFGKYLVGPVRDNAKAVRKQQGLDAPSVATAAK
>NC_015690.1|WP_013915189.1|1480029_1480419_-|hypothetical-protein
MNLTPTQQLLMEALGRSTDGKIHNGAEYLLKTGLLFEINRRILHPLGLAMRVVIEKHEDGTSEYSFAPYLFDNRDNEVGELFDEDTLRGGEQCLLEFMEDFGVGKMQERLRHLGFIIQRSQEPVRYEHI
>NC_015690.1|WP_013915190.1|1480777_1482436_+|right-handed-parallel-beta-helix-repeat-containing-protein
MLDVRELGAVEGGKADCTAVFQEAVDRAKATGDKIFVPIGTYRIEGQLRGLDNVFIEGVASNKQYWSQEDDFATGASVLVGGGANVLFAEDVQRATIDNLCFTDFAKIAERTSPRSMRFRNCSFKNMVVLDAPSGEKGAYHNFRFFGCDFTNYGIDVTFKGRIIDSVWKDCTFVGAAAFDLVQAKANLIAHNRFEWIDRSFAIAMYACEYKQIIENFFDRVMGNAIVLRQGNRHIHVSENLFNRCGSGLTSGGKPADPPLTETAHAFIQLYGEFENVSIQNNVFCRGSSGDRGGEETPKYVLSKERNIPGCLFTFRGNLTESACTDRLLYVDGEQYGKMSADTDAVFSALTEDVVDLARISRGPVTVYNSAAVKVTEIPLHLIVHNAGGRIKLAPGGIQAGLVYGGRVNGRPRYSRDEILFESVEPSRAEGKAGGSRLVYEVPVPRSMSGAPHTLNLLYRTGGKPDGSVELCGEDGRVLLKLPPLPPLAGAEEQGAYTETFVVSEGYLGQMMHLHIYASRDQPDAAGAWVEVEAVSVGYGRSVSKTFTDRMR
>NC_015690.1|WP_013915191.1|1483292_1483970_+|response-regulator-transcription-factor
MITILLVDDDNHIRELMKLSLREEGYRLIEAGDGQAALHCLEEVQVHLVVLDVMMPRMDGFELCRQIRRKYNDLPVLMVTAKGETGDKVEGFQLGADDYLVKPFDPRELIMRVKSLLRRYKLAGSDRIQLGRVELDKKGYEVIRGQEHLTLPLKEFELLHMLASHPNQILTRNQLIEGIWGLDYEGDDRTVDVHIKRLRERFKGEEEGFVIKTIRGLGYKLEVKA
>NC_015690.1|WP_013915192.1|1483966_1485349_+|HAMP-domain-containing-histidine-kinase
MRGSLYTRIVLAFLVSVILGLFIAFYATGLLFAERIWNNMKEDLHFVALDLIDTYQMTNGMDINQYLEARVLTRPFYVSLIDAEGGFREFGYRNVKNKRSVDQEAVKQVLAGGVHYSVLEEGGDEGALLGYPMEIDGRQYALFVQPAAPKMALNIRNAMITALAIELVAGSFFILIGARYLVNPLKLMTRASRRIAKGDFNISLDWKRRRDELGELAVSFTEMAGELKQMERMRQDFVSNVSHEIQSPLTSIAGFSKVLQQRQMPEEERKEYLRIIEAEAQRLSRLSENLLKLASLESEHHPFHPQTYDLDEQLRNVILTMEPIWSAKDIELDLDLPSVKVQGDPDQLSQVWLNLIGNALKFTPESGTVRIAIKTGVDKVQVKVSDTGIGISEEDLAHIFRRFYKADRSRTSANGGSGLGLSIVKKIIELHGGTIAVESRPGEGTEFTVTLPYVLLKRRD
>NC_015690.1|WP_013915193.1|1485470_1489268_+|S-layer-homology-domain-containing-protein
MNSTASSRVKRFTYMIKLLLCTAIVLAGAVPLSLSASAQPLPDLVFFGENPNTSHWGVEVQKENDLLPFDASVAFNGHPAHRVTNVSGGWWGIGMTLQWTTRDISGYIPYGALEFELKGSRGGELLQFSLSDGRSPAAETGSVPAEASASWNHVTIPLAQFPQIGSFPASAWNTLLITKVNGEDLNTLWLSDMKFTSRYITGYEPLILTAPQGTVPAMPSVVTAVYSDSTTTEVPVTWSGVPDGSAAGAFTVQGHVAGVSVQPTAEVTVGTEADQGTGSEEPQPAQETPPAVETPSLETVPSSGQQEHVVFEGVRTDQYFGSGGSLKLETDLVSTSSLPVDSTVEGTYNGQPSYKIAVTKLADPNWGYWNGVLAADGWTSYSLEAFREGTLEFYVKGAAGGEDFVIGIMDTNDVKSVLSLSGLAQTVTTDWSLIRIPLSRFTEQAPDLDLSIIDKVVLENASTQGEMSVWLNRIKFTQNPAAELEIASVDPVKAVTVAGLPPELPQEVPVTYENGTTGTANVSWEAGDGYRVRGRYTVRGTILQDTGPVPVTAEVTVVRALSDEPHVIFLDKKKAQWASAEGHFSLGMEQALDDQGMPVTNEQGNPVMTLPIDPQVTFGGLPAYRLQVTRIPGPNWGYWGTGLTMDNWNPVDLEALYERGSLDFMIKGLAGGESFSVVLTDRAGALGTVKLSDVAAVTTGWRQVSIPLKRLVPVSSAHRLKESTAVTLTSDTGTGAAPLTVWLSDMRLASEASREVVRFGTKLTVPASQLPQLPELPATAEAVYNDGTAEQVPVAWDAVTFSSWGYPNPVQGTAQGIDLPATLQFTVEGSRSSGSSGSGSGSGSAGMPEEPEAPIAAPVVPAASSLYPNGAAGTYTLPALKPAVDPADALLAVVNVQPGALKEGYKAAAPGPGQRPVMHIKVPYMSGVTGYAVELPAGTVSGAYPDAELSVTTDLGRVVLPADLLNPDQLNGAAAIRLVIRRSDTADMKKTVREQVGGRTVLDIHLEADGVILPWESREKRVLVSPDYAPTDEELEHPERLVILYLGEDGEAEPVPSGRYDRTGGRMIFSAGHFSRYAVAWGSRTFGDLAGYGWAQEAVELLASRGIVQGTGPTEFAPGRGVTRAEFVSLLVRTLDLAGLPAEADFRDVDPSSPHYQAIAAAARLGIAGGIGGGLFAPDAPVSRQDVIVLTERALERAGRLHAGAADSLPSGVFRDAEDLAGYAVPAVSALYGAGLIEGAGGLLRPEAEMSRAEAAVLLNRIYPY
>NC_015690.1|WP_013915197.1|1491521_1494107_+|EAL-domain-containing-protein
MAVPEAAGSKGSVLIYISFTFLAFLCCFLPVQLVLGTEMVFASFFFLITLRRFGAALTALQVTAVHVAASVFLHEPLLSSLVNTVEIGAVFLLLRTRLRSVLPAAALFWGLLGIPLLLIIYYIRFGTLGAEIGLYTVTLLVSRLFNALMADLIWTYLPHLRKQAKAGGRTGVQLSRLLLHLTLFSVIGSSFLFMVNTGKNAQSNLEAELQEEAAGLTASLSKSYASWSPEQVRALKLHSLIQAGYFRELAVTASQLISDEGVLIGPRGEVVVTYGGSTHGAAADWMRRTEWRPLTPSLFEWRTPARLLDIPGNQWQRMAVVAEVPLPPFKLYMKMSTVQHKEEILGYYLSQSVNVIFTTLVIGVFALFIHRFVLGPTIRLAELTRDVPGRLKENRSIAWMPPSRISEIQTLLGNFQELTEQLSVMLRESKAQAYYDALTGLPNRRHFNEHLQELLGPEAETAGTTAVLFIDLDRFKQINDTLGHAVGDGLLQEVAARLTGMVGSRAFIARLGGDEFVIVVQDTNNAEVCEMSKKVLRGLAEAFQVGEHELFVAGSIGAALSPQDGSDPETVVKNADAAMYLAKEEGGNAYRFFSGQIAGSISENMRIEFDLRRAIERGELHLHYQPIVDAADDKVVGAEALLRWDHPELGPIPPLQFIGIAESSGLIGTLGEWVLREACGQGARWLAQGLPLFGIGVNLSPTQLTHNNVVDYIGKVLEETGFPPEYLNLEITEEVFSKKTERVIHDLTLLREMGVRVWVDDFGTGYSSLAMLSKLPVVGFKIDRAFIREMGQDLAIVKTILSLAKDKEWIVVAEGIEEEEQKGALLELECRFQQGFHYSRPMPPEELARLLESQQKKGGTA

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Crispr_ID: NC_015690_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015690_9

1678344-1678446

Orphan

Consensus_repeat	Method
CGTGGAGGTTCGAGTCCTCTTGACCGCAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015690_9

>merge|NC_015690|9|1678344-1678446|CRISPRCasFinder
CGTGGAGGTTCGAGTCCTCTTGACCGCATTGCTTATTTATCCGATGTATTGGGAATAAGCAGTGCAGCACGACACGTGGAGGTTCGAGTCCTCTCGACCGCAT

>NC_015690|9|6|1678344-1678446|CRISPRCasFinder
CGTGGAGGTTCGAGTCCTCTTGACCGCAT	TGCTTATTTATCCGATGTATTGGGAATAAGCAGTGCAGCACGACA
CGTGGAGGTTCGAGTCCTCTCGACCGCAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_015690.1\|WP_013915387.1\|1674257_1674581_+\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013915396.1\|1678760_1679897_+\|DUF2264-domain-containing-protein	unknown	unknown	gnl\|CDD\|378358
NC_015690.1\|WP_013915408.1\|1689818_1690661_+\|lipoate--protein-ligase-family-protein	unknown	unknown	gnl\|CDD\|223173
NC_015690.1\|WP_013915395.1\|1677104_1678103_-\|LCP-family-protein	unknown	unknown	gnl\|CDD\|224235
NC_015690.1\|WP_013915386.1\|1673432_1674002_+\|xanthine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|181705
NC_015690.1\|WP_014369339.1\|1687765_1689568_-\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|350769
NC_015690.1\|WP_013915392.1\|1676370_1676598_-\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013915402.1\|1683429_1683657_+\|YqzE-family-protein	unknown	unknown	gnl\|CDD\|372887
NC_015690.1\|WP_013915405.1\|1685566_1686502_-\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013915391.1\|1676090_1676312_+\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013915397.1\|1680002_1680488_+\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|224168
NC_015690.1\|WP_013915399.1\|1680756_1682466_+\|arginine--tRNA-ligase	unknown	unknown	gnl\|CDD\|183534
NC_015690.1\|WP_013915390.1\|1675297_1676017_+\|adenosylcobinamide-amidohydrolase	unknown	unknown	gnl\|CDD\|376682
NC_015690.1\|WP_041617771.1\|1675070_1675301_+\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013915385.1\|1672359_1673079_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NC_015690.1\|WP_013915403.1\|1683875_1684037_+\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013915388.1\|1674650_1674974_-\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013915384.1\|1671521_1672145_+\|DedA-family-protein	unknown	unknown	gnl\|CDD\|223659
NC_015690.1\|WP_013915404.1\|1684078_1685443_+\|arsenic-transporter	unknown	unknown	gnl\|CDD\|238538
NC_015690.1\|WP_013915400.1\|1682761_1683178_-\|YjdF-family-protein	unknown	unknown	gnl\|CDD\|378596

Protein	Function_ID	Function_description	E-value
NC_015690.1\|WP_013915396.1\|1678760_1679897_+\|DUF2264-domain-containing-protein	gnl\|CDD\|378358	pfam10022, DUF2264, Uncharacterized protein conserved in bacteria (DUF2264). Members of this family of hypothetical bacterial proteins have no known function.	7.03071e-160
NC_015690.1\|WP_013915408.1\|1689818_1690661_+\|lipoate--protein-ligase-family-protein	gnl\|CDD\|223173	COG0095, LplA, Lipoate-protein ligase A [Coenzyme metabolism].	7.53925e-62
NC_015690.1\|WP_013915395.1\|1677104_1678103_-\|LCP-family-protein	gnl\|CDD\|224235	COG1316, LytR, Transcriptional regulator [Transcription].	4.7397e-57
NC_015690.1\|WP_013915386.1\|1673432_1674002_+\|xanthine-phosphoribosyltransferase	gnl\|CDD\|181705	PRK09219, PRK09219, xanthine phosphoribosyltransferase; Validated.	1.28909e-89
NC_015690.1\|WP_014369339.1\|1687765_1689568_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|350769	cd18011, DEXDc_RapA, DEXH-box helicase domain of RapA. In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	2.73657e-59
NC_015690.1\|WP_013915402.1\|1683429_1683657_+\|YqzE-family-protein	gnl\|CDD\|372887	pfam14038, YqzE, YqzE-like protein. The YqzE-like protein family includes the B. subtilis YqzE protein, which is functionally uncharacterized. It is a part of the ComG operon, which is regulated by the competence transcription factor ComK. This family of proteins is found in bacteria. Proteins in this family are typically between 49 and 66 amino acids in length.	7.69239e-20
NC_015690.1\|WP_013915384.1\|1671521_1672145_+\|DedA-family-protein	gnl\|CDD\|223659	COG0586, DedA, Uncharacterized membrane-associated protein [Function unknown].	5.59132e-42
NC_015690.1\|WP_013915397.1\|1680002_1680488_+\|N-acetyltransferase	gnl\|CDD\|224168	COG1247, COG1247, Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane].	4.65038e-56
NC_015690.1\|WP_013915399.1\|1680756_1682466_+\|arginine--tRNA-ligase	gnl\|CDD\|183534	PRK12451, PRK12451, arginyl-tRNA synthetase; Reviewed.	0
NC_015690.1\|WP_013915390.1\|1675297_1676017_+\|adenosylcobinamide-amidohydrolase	gnl\|CDD\|376682	pfam01955, CbiZ, Adenosylcobinamide amidohydrolase. This prokaryotic protein family includes CbiZ which converts adenosylcobinamide (AdoCbi) to adenosylcobyric acid (AdoCby), an intermediate of the de novo coenzyme B12 biosynthetic route.	9.2697e-69
NC_015690.1\|WP_013915385.1\|1672359_1673079_-\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	0.000905719
NC_015690.1\|WP_013915404.1\|1684078_1685443_+\|arsenic-transporter	gnl\|CDD\|238538	cd01118, ArsB_permease, Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.	3.57341e-104
NC_015690.1\|WP_013915400.1\|1682761_1683178_-\|YjdF-family-protein	gnl\|CDD\|378596	pfam11208, DUF2992, Protein of unknown function (DUF2992). This bacterial family of proteins has no known function. However, the cis-regulatory yjdF motif, just upstream from the gene encoding the proteins for this family, is a small non-coding RNA, Rfam:RF01764. The yjdF motif is found in many Firmicutes, including Bacillus subtilis. In most cases, it resides in potential 5' UTRs of homologs of the yjdF gene whose function is unknown. However, in Streptococcus thermophilus, a yjdF RNA motif is associated with an operon whose protein products synthesize nicotinamide adenine dinucleotide (NAD+). Also, the S. thermophilus yjdF RNA lacks typical yjdF motif consensus features downstream of and including the P4 stem. Thus, if yjdF RNAs are riboswitch aptamers, the S. thermophilus RNAs might sense a distinct compound that structurally resembles the ligand bound by other yjdF RNAs. On the ohter hand, perhaps these RNAs have an alternative solution forming a similar binding site, as is observed with some SAM riboswitches.	2.33487e-46

>NC_015690.1|WP_013915395.1|1677104_1678103_-|LCP-family-protein
MRKWVKYVIVGIIVAGGAAGWVYRELLPSRHFEEKEHPVVAVPAADLPASAEVSAAAGQPEAAAEKPQTGTQEKADPGAFNVLVLGLDTLGQQSSRSDVIMLSRVKPQERKVNLVSIPRDTRVPLPGIGLTKVNHAHFMAELKGGGEAGTEASIQAVSNLLQVPVHYYVKMNFKGFVDFIDEIGGVDIDIPADVFLTAIQQNLPAGRQHLDGWKALAFVRERYSLDNGDFGRQADQSALIRAVVHKLLSPERLPELPGLIQKIKKDVIDTNLTDSDILSLTLMYKDLMPEDMVYVQLPGAALTAQDPLVGQPLWYWEPDLPAVRSIGSQYLR
>NC_015690.1|WP_013915392.1|1676370_1676598_-|hypothetical-protein
MVVLQILAGILLAVLFWKLVQLTVHILLTAVSLFFLLSLVFPGVLLLLGSLLLVMVSLIATLALLCIGASFRTKT
>NC_015690.1|WP_013915391.1|1676090_1676312_+|hypothetical-protein
MERRREEPCRSMELEKDYILQLYTVGSGVEGEVVMRNRNAPGTGTHLFHVPLQGSEEEAASWAHTALRAIREG
>NC_015690.1|WP_013915390.1|1675297_1676017_+|adenosylcobinamide-amidohydrolase
MRGAQYEPLPIEGLRFGYVDSGYESVMIVESGTPMRVLNSSMWGEGFTASRRLVNRQVSKHYLADDPLEEMRAYFEGQGMPWEETAALLTAAELHDRGTRYVELGLGGGVYTWVTAGLRNKIRGGKDCEESALYPGTINTIVVVDGHLTDAAFVNAVITATEAKTAALQDLDVRLEDCGLTATGTSTDAVIIAALQRGERFRYAGISTTLGYAISRTVYESTVESAARYLNRQTLSPGE
>NC_015690.1|WP_041617771.1|1675070_1675301_+|hypothetical-protein
MITDEELDRYRVDGTLLRVVRDADRANDVRGYVVAWDDHTVMIRKRTRRVVKLDRSYVYQPYTETRAELFAEEAES
>NC_015690.1|WP_013915388.1|1674650_1674974_-|hypothetical-protein
MDKKTYYIAVGSGEILEPADTTGNFEFEIQATPEEIDQLAELFEDQDDAEGDTAARAIIPYRLYHKDKENDAYDANLQEIYRILHQLGTPETRSHIESMNILDGLRP
>NC_015690.1|WP_013915387.1|1674257_1674581_+|hypothetical-protein
MGKEIPVDFFVTKLNEAKIHFERALDCKHTDFDDLYPYMIEHPQFFWYKRYVAWSELLTIVKLCKELEVSWEEQFTEQQIEYINKRVMSSKVLDYWFETNDSREHVG
>NC_015690.1|WP_013915386.1|1673432_1674002_+|xanthine-phosphoribosyltransferase
MELLKEKIREVGVVVSDEVIKLDAILNHAVDPVLTTEMGREFARRYREQRVTKVLTIESSGIPIAFAAAQELGVPMVFARRKKTLNTDTETYCERVPSFTKGFVTDIMVGKEFLSENDRVVLIDDFIANGDAARGLIRIIRRSGAELLGLGIAVEKSFQAGGRTIRESGVRVESLVRISSLAGGRIEFE
>NC_015690.1|WP_013915385.1|1672359_1673079_-|hypothetical-protein
MTRERALTGFLSVLTITSLLTAAGCQSGGPGAAPPQSPSGSAVEQQKPAAVLDVPAGPPTPAPQPAPASPEDQVSLASNAEKSGGTVLPPQPKDTKGKTAAADKPKIEIQSPYTEANPTLLGLTLKTAASEITGKFGKPKEQFVMEDDADPVTVYDYTDFLVGFNSRNELHFVDVRSADVNPGLNGLKLGDPVSSVYEALGKPDSNTSYVLTYKATGAILKLDIDPKTQKVNSIKLFAE
>NC_015690.1|WP_013915384.1|1671521_1672145_+|DedA-family-protein
MEHLLQYINQYGYIALYGLLALGIVGVPVPDEILMTTVGTLTTSHNPVLHFGTTLLVSFLGAMTGMVVSYALGRTVGKPFLYKYGRWIKLTPERLAVAEGWFKKYGMWAVFFGYYVPGVRHFTCYLAGVSNVRIWRYLLYAGSGALVWVTTFLTLGHVIGANALRLLHSLHHHMALPIVLILILVVGAFLFLRYRRRKKSAFGSSSE
>NC_015690.1|WP_013915396.1|1678760_1679897_+|DUF2264-domain-containing-protein
MHEHRTYWIESLSRIAGPVLNALAGRRLKELMPVEAHSEDRAQCSHLEALGRTLAGIAPWLESGGREGEEGRLRETFAGLAREAVDAATDPASPDYMNFSEGTQPLVDAAFLAHALMRAPGELWERLDERVKRQVIGALKAARTIRPWFSNWLLFSGMIEAFLDRAGEGGDPMRIDYALRQHEQWYLGDGMYGDGPEFHWDYYNSFVIQPMLIDIVEQAGRRYPEWEAMREPVLRRAGRHAAVLERLISPEGTFPPIGRSLAYRFGAFQLLAQMALRRELPESLEPAAVRCAFTAVMRRMLEAPGTFDADGWLTIGFCGHQKNLGEGYISTGSLYLCTAVFLPLGLPADDPFWTGEAEWTSRRLWSGGEAPIDGALYG
>NC_015690.1|WP_013915397.1|1680002_1680488_+|N-acetyltransferase
MIIRKAQAGDLPAIVDIYNEAVLNTVATFDTVPRTLEQQEAWFKQHGDAYPVIVAEQDGTVVGWASLNQYSDRLAYARTSELSLYIHAGHRGQGTGKKLLEAVLAAGREAGLHTVLSRIVEGNDSSIHIHHVYGFETVGTMRQVGFKFGRMLDVILLQKML
>NC_015690.1|WP_013915399.1|1680756_1682466_+|arginine--tRNA-ligase
MNYKQWLAQQLAGKFEGLDRETLADLIEYPPNPQMGDLSLPCFKLAKQLRKAPQAIAEELKAGWTGDESVERVDAVAGYFNVYLNPAKFAAQVVGEVREKGDRYGSQNIGQGRNIVIDFSSPNIAKTFHIGHLRSTVIGNALYKIFEFLGYNSVGINHLGDWGTQFGKLIVAYKLWGDKDAVEADGIAELQRIYVKFHDEADKNPALDDEARAWFVKLEQGDAEATELWRWFVDISLKEFHKMYDLLGVTFDSYAGESFYNDKMAAVVEELKAKNLLEEDQGALLVRLDDYNMPPALMIKKDGGTLYHTRDVTAAIYRKNTYDFDKAIIVTDAGQSLHFNQWFKVVELMGYEWAKQLQHVPFGKVSLENAKLSTRKGNVINLEDLLTKAIEKTRSIIEEKNPSMENKDEVARQIGVGAIIFNDLSNNRIKDIVFSWDDALNFEGESGPYVQYAHARACRVLGKADPAEVTAAASLNPEHLTNPEAQAVLRQLYLFKERVEQAMHKLEPSIVSRYLIDLAQSFNHFYHQCKIVTADEAEVRIARLALTDCFRTTIRNGLALIGLEAPEEV
>NC_015690.1|WP_013915400.1|1682761_1683178_-|YjdF-family-protein
MKLTVYFEGEFWVGVVEDESGGLYKACRHVFGSEPHDAEVLEFVQREMMPLLGRTQTGIDLGSALPDRGRVSPKRLAREAAREMQRTGVRSLAQEALARDLEHRRKTRRIVTKAQKEAEQARRREIAVRKAKARHRGR
>NC_015690.1|WP_013915402.1|1683429_1683657_+|YqzE-family-protein
MAKGDELVKYLTVQVIKYFETPKEERKLKRAGKREAREQWQYRWFGMLPLALSMWLEPLRRRFERLREARERNKL
>NC_015690.1|WP_013915403.1|1683875_1684037_+|hypothetical-protein
MITLLIVMAAGCSLYFVLKPPHPQGAVEAEPVAYAAALPEAHLSELPPALARE
>NC_015690.1|WP_013915404.1|1684078_1685443_+|arsenic-transporter
MMTEPAMISLTVFSFLMTMLLILLRPRGLNEAVPAVFGAVLVLFSGSVTLADLGQIGTTISGAAITIMATIVMAIVLESFGFFQWAAEGLAARARGSGIRLFWYVNLICFLMTLFFNNDGSILITTPILLILLKRLGLKNHHKIPYLLSGALIATASSAPIGVSNIVNLIALKIVGMDLYMHTLMMFVPSMLGLLFLVALLFLYYRERLPVKLPHRAPYFHGPGHHPLQHPADVTALRDRDRFMQRILLFVFLVRCSLFLASYLAIPIDLVAVLGSVLLLLWRWWALKIPPKDMLRKTPWHIFVFAFGMYVIIYGLNNIGLTQLLVTTFEPWVQDSLLSASFVMGGLTTLMSLMFNNHPALMIGTMTLTGMELDPLTLKTAYLAAVIGSDLGALLLPIGTLASLIWLGILKEHKVNLPWKEYVKVTFATIPPAMLFTLFLLAYWIEWVYGSVVP
>NC_015690.1|WP_013915405.1|1685566_1686502_-|hypothetical-protein
MVKILKKLTLALAALLLAGGLQAAGPLEYAPALAVEQPPRETGQTSETAAPAQKHQTAGSLEEAVQALIRELSAQEGFESWAKAEWTSYPLGPGTHGWVVLLKTDGVEAGYLVIQDAGAGRYLLSEYGRGEYPLFSLQTLHHSLVRLDLIPSDTHAERLYYNPLEALWQITAPGGPVRYLDAKTGEELPLHPGEIPHKELPAGEGISYQTGSPAPKPERLIGGSPFDAYERLPWVTSPPASPPSPAQLGEWLKQGSRPIYAAEVYGGRHLIPLAVTGLAVWSGGTAYVRALQDDDRYLPLGALHHLGGFYP
>NC_015690.1|WP_014369339.1|1687765_1689568_-|DEAD/DEAH-box-helicase
MQPTDRKVHLRQLNEHVQVHFERDWFEELHERALRNGPWDDFTMFKLAHEAEHAGLIHSFDELQCLTHLPNLVPMDHQVETAKKVLTGMRGRAILADEVGLGKTIEAGLILKEYMIRGLIRKVLILVPASLVLQWVRELNQKFGIPAVAQKKEYMWAQNDIVVASMDTAKRDPHREIVLGLEYDMLIVDEAHKLKNKKTTSYQFINELRKKYCLLLTATPVQNDLSELYNLITLLKPGQLGGKTSFQANFVVDKRIPKNEEQLQAELSKVMIRNRRSDGNVNFTKRIVRNIPLQLSPEEQALYDGVTNFVKGRFEEAGGDLSSVLSLVTLQREVCSSRDAVFITLVNMFKKTDESSPLRPRIWELVELIRSIKANTKAEKVMELIREINDKVIIFTEYRASQEYLLQYLKDHKISAVPYRGGMNRGKKDWMMDLFRNRAQVLIATEAGGEGINLQFCHNMINFDLPWNPMRVEQRIGRVHRLGQKEDVKIYNLSTTGTIEEHILSLLHEKINMFELVIGELDTILERFEKKTSLESHLAKLILASRSQDEIRRQLDDLGHTFTQVRSEVQQEAEGGSRLHSMLNAVGQTVADGGLEEVQP
>NC_015690.1|WP_013915408.1|1689818_1690661_+|lipoate--protein-ligase-family-protein
MNEWRWIRSGLSAPDYNMAVDEAILTAHSEGRVPPTVRFYGWNPPTLSVGYFQKAQTEVDFGALERQGIGFVRRATGGRAVLHDRELTYSMIVSEQYEGIPRSVTEAYRVLSQGLLLGFRRLGLAADMVQLESEEDKSQYASMGSAACFDSPSWYELVVEGRKIAGSAQTRQKGVVLQHGSILLDLDADQLFGLLKFASERVGERMKAQFLRKAVAINDLRQAAGLPDVTPAEVEEAFAHGIAEGLGIRLVPGELTPWEAELAERLVAEKYGNPEWNLRR

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Crispr_ID: NC_015690_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015690_10

2220840-2220996

Orphan

Consensus_repeat	Method
AAGCGACCTTTATGCAAAGCATAACGGAGCGCAAAAAGATATGCCCGAGCGCCGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015690_10

>merge|NC_015690|10|2220840-2220996|CRISPRCasFinder
AAGCGACCTTTATGCAAAGCATAACGGAGCGCAAAAAGATATGCCCGAGCGCCGAGGGGAAAACGATGCATGAGACTGGAAAGCGAGGAGATATCTTTTTGGAAGCGACCTTTATGCGAAGCATAACGGAGCGCAAAAAGATATGCCCGAGCGCCGA

>NC_015690|10|7|2220840-2220996|CRISPRCasFinder
AAGCGACCTTTATGCAAAGCATAACGGAGCGCAAAAAGATATGCCCGAGCGCCGA	GGGGAAAACGATGCATGAGACTGGAAAGCGAGGAGATATCTTTTTGG
AAGCGACCTTTATGCGAAGCATAACGGAGCGCAAAAAGATATGCCCGAGCGCCGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_015690.1\|WP_013915823.1\|2212742_2213837_+\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NC_015690.1\|WP_014369658.1\|2230554_2232066_-\|mannan-endo-1,4-beta-mannosidase	unknown	unknown	gnl\|CDD\|366944
NC_015690.1\|WP_013915821.1\|2208422_2210399_+\|YjhG/YagF-family-D-xylonate-dehydratase	unknown	unknown	gnl\|CDD\|236189
NC_015690.1\|WP_013915824.1\|2214062_2216393_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|225117
NC_015690.1\|WP_014369643.1\|2206042_2206918_+\|fumarylacetoacetate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|226479
NC_015690.1\|WP_013915829.1\|2221016_2222015_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NC_015690.1\|WP_041616747.1\|2219460_2220480_+\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|378890
NC_015690.1\|WP_013915831.1\|2225149_2226559_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|225121
NC_015690.1\|WP_013915838.1\|2233534_2234368_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_015690.1\|WP_013915832.1\|2226608_2227256_+\|beta-phosphoglucomutase	unknown	unknown	gnl\|CDD\|213672
NC_015690.1\|WP_013915826.1\|2217568_2218570_+\|2-keto-3-deoxygluconate-transporter	unknown	unknown	gnl\|CDD\|235384
NC_015690.1\|WP_013915833.1\|2227310_2229029_+\|beta-N-acetylglucosaminidase	unknown	unknown	gnl\|CDD\|366376
NC_015690.1\|WP_013915834.1\|2229089_2229371_+\|HPr-family-phosphocarrier-protein	unknown	unknown	gnl\|CDD\|376329
NC_015690.1\|WP_013915825.1\|2216517_2217525_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270234
NC_015690.1\|WP_013915827.1\|2218770_2219352_-\|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|225158
NC_015690.1\|WP_013915820.1\|2206939_2208406_+\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|143415
NC_015690.1\|WP_081473172.1\|2210761_2212282_-\|malate:quinone-oxidoreductase	unknown	unknown	gnl\|CDD\|377591
NC_015690.1\|WP_013915835.1\|2229384_2230491_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|369561
NC_015690.1\|WP_013915837.1\|2232661_2233534_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NC_015690.1\|WP_013915830.1\|2222209_2225143_+\|alpha-L-rhamnosidase	unknown	unknown	gnl\|CDD\|379971

Protein	Function_ID	Function_description	E-value
NC_015690.1\|WP_013915823.1\|2212742_2213837_+\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	7.29923e-22
NC_015690.1\|WP_014369658.1\|2230554_2232066_-\|mannan-endo-1,4-beta-mannosidase	gnl\|CDD\|366944	pfam02156, Glyco_hydro_26, Glycosyl hydrolase family 26.	6.4861e-70
NC_015690.1\|WP_013915821.1\|2208422_2210399_+\|YjhG/YagF-family-D-xylonate-dehydratase	gnl\|CDD\|236189	PRK08211, PRK08211, YjhG/YagF family D-xylonate dehydratase.	0
NC_015690.1\|WP_013915824.1\|2214062_2216393_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	2.60166e-27
NC_015690.1\|WP_014369643.1\|2206042_2206918_+\|fumarylacetoacetate-hydrolase-family-protein	gnl\|CDD\|226479	COG3970, COG3970, Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only].	7.94292e-55
NC_015690.1\|WP_013915829.1\|2221016_2222015_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	7.71419e-20
NC_015690.1\|WP_041616747.1\|2219460_2220480_+\|AraC-family-transcriptional-regulator	gnl\|CDD\|378890	pfam12625, Arabinose_bd, Arabinose-binding domain of AraC transcription regulator, N-term. AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].	4.11194e-35
NC_015690.1\|WP_013915831.1\|2225149_2226559_+\|MFS-transporter	gnl\|CDD\|225121	COG2211, MelB, Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism].	2.34796e-128
NC_015690.1\|WP_013915838.1\|2233534_2234368_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	1.14521e-52
NC_015690.1\|WP_013915832.1\|2226608_2227256_+\|beta-phosphoglucomutase	gnl\|CDD\|213672	TIGR01990, bPGM, beta-phosphoglucomutase. This model represents the beta-phosphoglucomutase enzyme which catalyzes the interconverison of beta-D-glucose-1-phosphate and beta-D-glucose-6-phosphate. The 6-phosphate is capable of non-enzymatic anomerization (alpha <-> beta) while the 1-phosphate is not. A separate enzyme is responsible for the isomerization of the alpha anomers. Beta-D-glucose-1-phosphate results from the phosphorylysis of maltose (2.4.1.8), trehalose (2.4.1.64) or trehalose-6-phosphate (2.4.1.216). Alternatively, these reactions can be run in the synthetic direction to create the disaccharides. All sequenced genomes which contain a member of this family also appear to contain at least one putative maltose or trehalose phosphorylase. Three species, Lactococcus, Enterococcus and Neisseria appear to contain a pair of paralogous beta-PGM's. Beta-phosphoglucomutase is a member of the haloacid dehalogenase superfamily of hydrolase enzymes. These enzymes are characterized by a series of three catalytic motifs positioned within an alpha-beta (Rossman) fold. beta-PGM contains an inserted alpha helical domain in between the first and second conserved motifs and thus is a member of subfamily IA of the superfamily. The third catalytic motif comes in three variants, the third of which, containing a conserved DD or ED, is the only one found here as well as in several other related enzymes (TIGR01509). The enzyme from L. lactis has been extensively characterized including a remarkable crystal structure which traps the pentacoordinate transition state. [Energy metabolism, Biosynthesis and degradation of polysaccharides].	1.84155e-97
NC_015690.1\|WP_013915826.1\|2217568_2218570_+\|2-keto-3-deoxygluconate-transporter	gnl\|CDD\|235384	PRK05274, PRK05274, 2-keto-3-deoxygluconate permease; Provisional.	1.18431e-156
NC_015690.1\|WP_013915833.1\|2227310_2229029_+\|beta-N-acetylglucosaminidase	gnl\|CDD\|366376	pfam00933, Glyco_hydro_3, Glycosyl hydrolase family 3 N terminal domain.	6.44232e-66
NC_015690.1\|WP_013915834.1\|2229089_2229371_+\|HPr-family-phosphocarrier-protein	gnl\|CDD\|376329	pfam00381, PTS-HPr, PTS HPr component phosphorylation site.	4.5965e-20
NC_015690.1\|WP_013915825.1\|2216517_2217525_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	2.45329e-102
NC_015690.1\|WP_013915827.1\|2218770_2219352_-\|NAD(P)H-dependent-oxidoreductase	gnl\|CDD\|225158	COG2249, MdaB, Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only].	1.86782e-50
NC_015690.1\|WP_013915820.1\|2206939_2208406_+\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|143415	cd07097, ALDH_KGSADH-YcbD, Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like. Kinetic studies of the Bacillus subtilis ALDH-like ycbD protein, which is involved in d-glucarate/d-galactarate utilization, reveal that it is a NADP+-dependent, alpha-ketoglutaric semialdehyde dehydrogenase (KGSADH). KGSADHs (EC 1.2.1.26) catalyze the NAD(P)+-dependent conversion of KGSA to alpha-ketoglutarate. Interestingly, the NADP+-dependent, tetrameric, 2,5-dioxopentanoate dehydrogenase (EC=1.2.1.26), an enzyme involved in the catabolic pathway for D-arabinose in Sulfolobus solfataricus, also clusters in this group. This CD shows a distant phylogenetic relationship to the Azospirillum brasilense KGSADH-II (-III) group.	0
NC_015690.1\|WP_081473172.1\|2210761_2212282_-\|malate:quinone-oxidoreductase	gnl\|CDD\|377591	pfam06039, Mqo, Malate:quinone oxidoreductase (Mqo). This family consists of several bacterial Malate:quinone oxidoreductase (Mqo) proteins (EC:1.1.99.16). Mqo takes part in the citric acid cycle. It oxidizes L-malate to oxaloacetate and donates electrons to ubiquinone-1 and other artificial acceptors or, via the electron transfer chain, to oxygen. NAD is not an acceptor and the natural direct acceptor for the enzyme is most likely a quinone. The enzyme is therefore called malate:quinone oxidoreductase, abbreviated to Mqo. Mqo is a peripheral membrane protein and can be released from the membrane by addition of chelators.	0
NC_015690.1\|WP_013915835.1\|2229384_2230491_+\|alpha/beta-hydrolase	gnl\|CDD\|369561	pfam07859, Abhydrolase_3, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	8.4987e-83
NC_015690.1\|WP_013915837.1\|2232661_2233534_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	5.9889e-68
NC_015690.1\|WP_013915830.1\|2222209_2225143_+\|alpha-L-rhamnosidase	gnl\|CDD\|379971	pfam17389, Bac_rhamnosid6H, Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain. This family consists of bacterial rhamnosidase A and B enzymes. L-Rhamnose is abundant in biomass as a common constituent of glycolipids and glycosides, such as plant pigments, pectic polysaccharides, gums or biosurfactants. Some rhamnosides are important bioactive compounds. For example, terpenyl glycosides, the glycosidic precursor of aromatic terpenoids, act as important flavouring substances in grapes. Other rhamnosides act as cytotoxic rhamnosylated terpenoids, as signal substances in plants or play a role in the antigenicity of pathogenic bacteria.	3.45748e-135

>NC_015690.1|WP_041616747.1|2219460_2220480_+|AraC-family-transcriptional-regulator
MDVSSQTMAISMVYPVMKAIVHKGFDTEPFCRYASFDSSLLKDVEARIPAEELERLMYAAVEYTQDDHFGLHQGQLMDMMDMGILGYVMMHSGKVADALSAYRRYNIILCSGFNLDWKEEGEEVHLRLFSEAPNGRISRHCMEDMASSIYHLIGRLSHRRVPLAGVEFMHEAPADTAPYLPVFGVEPRFGRAETVLRMSREVMDYPILYSDPKLRGMFEAIAEETRSRLAQGKLFSDRVYHWMMKCMPVQFPTLQETAKSFEMSARTLQSKLKEENTSYNELSAVVRKELAISYLKQPGYSVGDIAYLLHFSEPSAFQNAFKKWTGVTPGQYRAKGTAS
>NC_015690.1|WP_013915827.1|2218770_2219352_-|NAD(P)H-dependent-oxidoreductase
MTTKILVITGHSDPQSFCSALSRAYIEGASGSKAEVREIDLSRIAFNPVLKYGYNQRTELEPELKEAQELIRWAEHLVFVYPTWWGGMPAVLKGFIDRIFLPGFAFKYRENSVLWDKLLTGKTARLIVTMDTPSWYNRWIYGHAGHNVMKRNILHFCGIKPVRITEITPIKSTTPQQRAGYLERVKRLGAKLA
>NC_015690.1|WP_013915826.1|2217568_2218570_+|2-keto-3-deoxygluconate-transporter
MAIKKTLDRIPGGMMLVPLFIGAIVHTFWPDSGKYFGSFTNGLMTGTVPILAVWFFCMGAGIDIRATGTVLRKSGTLVLTKIAVAWIVAIIAGQFLPEGGIQTGFFAGLSVLALIAAMDMTNGGLYASIMQQYGTKEEAGAFVLMSLESGPLVTMLILGTTGLAAFEPHHFVGAVLPFMIGFILGNLDHDLREFFGKATHTLIPFFGFALGNSIDLGVILQTGLLGILLGIAVIIVTGIPLILADKWIGGGNGTAGLAASSTAGAAVANPMIIANMKPEFMSAAQSATALVAACVIVTSILVPILTAYWADWMKKRRGSVPVQGVGPGQERTV
>NC_015690.1|WP_013915825.1|2216517_2217525_+|tripartite-tricarboxylate-transporter-substrate-binding-protein
MTRRWSRRFAGALPLLLLLTACTGEWLPAKGTESRETEAFPRKSITLIVPYAAGGGTDLTARALAKAAEKHLPQPIAVVNRTGGGGSIGLMEGAGTKADGYTVTYLVAELTTLPHLGLLPVTYEDFKPIAQTNLDPSAITVRAEAPWTTAAEFLDFAKAHPGKVKMGNAGTGSIWHLAAATLEKGTGVKFSHIPFEGAGPAVSALTSGFVDAVPVSPAEVKTQVEQGTLRTLAVNAEQRSEALPGVPTLKEATGLSVQFTGTWRGLAVPKDTPDEVTAVLAEAFTKAAGEEGFRAFMKENGLGLMIRDGEGFRGQMKASHDAFARLIPELGLSRK
>NC_015690.1|WP_013915824.1|2214062_2216393_+|helix-turn-helix-domain-containing-protein
MLRIRFKYIAGNKRTKLILVLALCISLCIGTVGLYSYSQYRRALDTELNTPNVELLQINLDVSNRAFREADGRAVDVSFHEAALGFISSQSSDRESRSASLQAYLQTMAEKPDIHSIEVLALEGRSRVSSLGGYPSGWSGGAPLEGWMAELNDKPLLVKRRSAGGVQGAGTTELLSLVRPVRQNGQVTGAVIVNLDYDRLFSKLYTSSANYLYVYNLDGELIYPKLNLPIPLSGMEEVTGGLDVRPFAYVRAEGQEYMANQTFSDVTGWRLISLVPVEKLLKNAKLARDMMLLLSLLSIAVGCAAVYSYNYAAFRPLKRIQRLLRPLQRDAAAQGDLYDLEPVIGKLVEEWHRESLVARQSLPELRSKFLEDLLARSLGAREAQAKWEQYFQDWKPGDLTVFVVSIDRYGEWASRFPEEDRRLLKYALNNILLEALEPAWRAVSMGDPPDGAALLLQPKDPDRAAPEREALSREAARIREMLSQYLSLSVSAGIGPAVPSVTQAARSLAEAREALSYRLYAGYGSIHARPTAVLPAEKDEPSGRGDAGTAEWLSALAAGGSEACAEWARSWTEAFRTGGVRPSSVYREVDALMEELLRTATALGAVPPAELADYTPGQGATLELGDVAALLERCLTAMARELASRRQRREYQIVQAMKDYMEDHLDGNIGLQEIADSVQMSISSVSSMFKEETGSTIYDYLTHLRIGRACRLLEETPMKIAEIAQRVGYQNENSFIRAFRKVKTVTPGRYREGIKSSGGYADRPNPRSSGISEDLP
>NC_015690.1|WP_013915823.1|2212742_2213837_+|Gfo/Idh/MocA-family-oxidoreductase
MSRPAVFGIIGGGGFRAQYFLRIAQALPDEFRVGGMVVRDESKGREMEQQWRVPTYRTLEQLLESESLDFVVVSVSASAGYEYLLQLAERGIPALAETPPAPDLEGLHLLHEKLTCRGARVQVAEQYPLHPMNQARLAVIAEGRLGKVTEATVSISHFYHGIGLLRKMLGIRFEDAHIRAMRFQSEWVAGPSRSGPPTEEQIIPSQRDLAWLNFGGKLGIYDFTKDQHRSWIRSNHLSVRGVRGEIFDDRLTVLEDFRTPLHLNFKRVNKGELENQEGYFLKGILAGERWVYENPFAPARLYDDEIAIAGCLRKMAAYASGGPSFYSLPEASQDCYLGMLLEQAIHTGTDVVSERQPWAMEETR
>NC_015690.1|WP_081473172.1|2210761_2212282_-|malate:quinone-oxidoreductase
MSNRQTRTDVILIGAGIMSATLGTLLKELVPDWNITVLEKLPKAGEESSNEWNNAGTGHAALCELNYTAEKPDGSIDISKAIKVNEEFQVSMQFWSYLVKSSLIRNPQEFIMPLPHMSFVHGAQDVAYLKKRFEAMSANPLFQGMEFSDDPSKLAEWMPLMMKDRTSNEPIAATKVDSGTDVNFGALTRILFDHLKKKNVDIKYKQHVDDIKRTGDGAWELKVRHVDTGTVERHTAKFVFIGGGGGSLHLLQKSGIPEGKSIGGFPVSGLFMSCNNPEIVEKHHAKVYGKAKVGAPPMSVPHLDTRFIDNKKSLLFGPFAGFSPKFLKTGSMLDLITSVKPHNLTTMLAAGAKNMPLTKYLIQQVMLSKEQRMEELREFVPNARIEDWDLVVAGQRVQVIKDTAAGGKGTLQFGTEVINAADGSIAALLGASPGASTAVSVMLEVIKKCFPQQLKAWEPKIKEMIPSYGVSLVKNPELVQELHTSTARTLGLSEKGAVKVAHRTVS
>NC_015690.1|WP_013915821.1|2208422_2210399_+|YjhG/YagF-family-D-xylonate-dehydratase
MSERITSIMGSDNPGDAEIQTHAPGVQGRLPLTDELLRHAPSGDLFGLSQNVGMGWKPGRLNGRQFLILSTQGGLRGEDGSPVALGYHTGHWEVGLLMKAAAEEISSQGGIPFAGYVSDPCDGRSQGTTGMFDSLPYRNDAALVFRRLIRSLPTRRGVIGIATCDKGLPAMLLALAGMPQLPGIIVPGGVTLPPTEGEDAGKIQTIGARYSTGELTLEAAAELGCRACATPGGGCQFLGTAATAQVVAEAMGLTVPHAALAPSGQPIWEEMARQSSRALMAMEADGLRMGDLLTDAAVHNAMAVHAAFGGSTNLLLHIPAIAHAAGLRMPTVQDWIRINRDVPRLVSVLPNGPVFHPTIRVFLAGGVPEVMLHLRRLGVLEESVRTAAGTTLGQVLDWWETSERRHRLRGQLLEKDGIDPDSVIMSPERARQLGITSTVTFPTGNLAPEGSVIKSTSIDPSVLDAEGVYRHKGRAKVFTTEREAMRAIKNGGIQAGDVLVLIGRGPSGTGMEETYQLTSALKHLSFGKQVALLTDARFSGVSTGACIGHIGPEALAGGPIGKLRDGDLIDIVIDRSRLEGRIHFVGEGEREVTPEEGAVILARRPLHPDMRPDEALPDDTKLWAALQSVSGGTWSGNVYDVDRIVTALEAGKKALGWS
>NC_015690.1|WP_013915820.1|2206939_2208406_+|aldehyde-dehydrogenase-family-protein
MTAFQGEQVYRNYIQGEWTAASTGRTVPSLNPANRQEVVGYVPDSASEDVDRAVAAAQAASRAWRRLSGAERGSVLHRAANVLERRADEIAETMTREMGKTLSEAKGETLRGVAILRYYAGEGMRSIGEVIPSTDSEALLFTTRVPLGVVGVISPWNFPVAIPLWKTAPALVYGNTVVLKPAQETAVTAAKVTECFAEAGIPAGVLNLVCGSGSVIGPALAEHPGVNGITFTGSNAVGKQVGRAALARGAKYQLEMGGKNPIIIAADANLDLAVEATISGGLKSTGQKCTATSRVIIVREVYEAFKAKLLSQIASIRLGDGMSADSWMGPCANERQMDTVLQYIQQGLDEGAVLLAGGARADGPGLSDGFYVQPTVFDGVTPQMSVAREEIFGPVLALIAVDSLQEAIDTANDSDYGLSASIYTQNIGAVLSFIRDMDAGLVRVNAETAGVELQAPFGGMKMSSSHSREQGQAAIEFFTSIKTVFVKP
>NC_015690.1|WP_014369643.1|2206042_2206918_+|fumarylacetoacetate-hydrolase-family-protein
MRVIRFRDGGQVKLAAVTDEERAYLLPQEDVMALIHEAGERGLTPLRLVESAVKPENELPEAWTALELLTPLDAPEVWAAGVTYQRSREARNYEATGGRLDAQTFYDKVYDAVRPEIFFKSTAARTVGPNQPVTLRRDSSWQIPEPELGLVLARDGSIVGYTAGNDMSCRDIEGENPLYLPQAKIWRRSCSLGPAVRLAETVADPYDLRIACRIYREDRLVVEGTASTGQLNRRLDELVSFLAADNELFDGTVLLTGTCIVPPDEFTLAPGDRIEISIDGIGTLVNGVTAN
>NC_015690.1|WP_013915829.1|2221016_2222015_-|AraC-family-transcriptional-regulator
MNLSELEALLRRRNQTSDWTAVRDKFQPDYTMIDGMEAYHFYSAVDVASELVEGSIAISQQPYESYIPLHIHNYLELTYVYEGSCTVQIQHKEIPLGKGSFIFVDKEVPHRVLETKPTDIVINIILRMDYLSPAFLSRLSHQSIISSFLVDSLVDSRRRNRYLLFQADSRDERIPHVMEQIMCEYYDRKAYSQQIIDSYLVILFTEMIRLNEQLLKVKGDKEDKPAHSLIDFLKYIEDHYRDCTLTQMAAHFNFHPNYLTALLKQGTGKSFKELLQLQKISKATLLLQHSDLPIEQIVGEIGYSSISFFYRKFSEIYGMTPVQYRKRREAML
>NC_015690.1|WP_013915830.1|2222209_2225143_+|alpha-L-rhamnosidase
MAAGHQANQLQAINLRCDYRKNPIGTGEKQPRFSWQLISEDRGTTQTAYRVQVGRESGDFGEPFWDSGKIPSEDSLHVKYEGPQLASRTRYYYRVKVWDQAGNESAWSEPAWWETGLLDESEWKAQWITPHPDAVDPRTEAVFLLRKRIHVRPGLQRAVAYASALGLYELYVNGERAGDAELTPGWTSYHHRIQYQAYDVTRHLQEGGGGIGILLADGWYKGGMGDAHNRFRYGERRAAFLQLHLRYEDGNEEAVVTDASWLASTGPILSSSLYDGEVYDARLERSGWCGASAEELGWHPVTAVEPPAAQLIAQENEPVRVTQVIRPVRSFLTPAGAAVLDMGQNMVGRIRLKPDVPAGTVLTLRHAEVLDRDGEVYFGNLRTAKQTVVYTAKGEPGETYAPHFSFQGFRYVQVEVLPIRENGPESHSGPLPLDCFAGEVMHTDMEPAGSFECSHEGINQLQRNIVWGQRGNFVDVPTDCPQRDERLGWTADAQVFMRTALFNYNGGAFFTKWLRDLKADQLPDGGVPFVVPDTKVGSSSAGWGDAAVICPWIFYQVYGDRQLLEEQYDSMKGWVEYIRAQGPSEYAWTTGFHFGDWLALDAKENSFTGATPKELIATAYYAYSTRLLRDAAAVLGRTEDVREYTELYEKVVAQFRGEYVTPFGRIASPTQTAHVIALAFDLVEAPMKARIAQSLNELIAEHNGHLSTGFIGTPLLCFALSDHGYHDTALKLLLQEDYPGWLYAVSKGATTIWEHWDGIKADGSFWSDHMNSFNHYAYGSIGDWLYRRVAGIDLDPAAPAYKRIRIAPGIGGRRLTSARASHESMYGMITCSWQVVNREEVHVTLRIPANTTASVILPGCTLAGLAESGLPAASADGLSSFEEGADSLAFEAGSGEYRFVYRAPALFANRFTVENKVRELQDDPEVKEVLERHLPELLAPPLMYFAKNWTLQQLANDPQLPVTDERIAALLQELQEA
>NC_015690.1|WP_013915831.1|2225149_2226559_+|MFS-transporter
MNAKHEAAPGTASGAEGAYVKISLKEKLGYALGDFSTNIIWTAISTFLAFFYTDVAGISAAAVGTILFVTRFLDGVADLGVGVLVDKTKSRHGKARPWLLWMGIPFGLSVMLLFTAPDLGPTGSIIYAFVTYLIVNLLYSAINIPYGVLNSLMTQEPYERSLINIFRMVLAISGGVMISVATMPVVQMFGGGRQGWIITFVIIGLIAPFLYLITFKTTKERVRPTVVQKEVPLKRGVAALFRNKYWLLIVGYSALIFIAQGLGSALNIYYAQYVLKNAGLVGLLALASLLPIVVGIILSAPLVKKFGKRNTSLIGLAVSLIGALLLFVDPTNLQLVLASIVIKNLGLAPSVAIGNALFADTVEYGEWKTGIRTEGLIFSGGSLASKIGSGLGGAVVGWALAWGGYVSKLEVQPDSAVTAIKILFMYVPIAILAVQILLMLLYKLDQKYPQIVEDLKAIASERDLEAGRN
>NC_015690.1|WP_013915832.1|2226608_2227256_+|beta-phosphoglucomutase
MSKKAVIFDLDGVIVSTDEYHYRAWKRLCEEEGIPFSREINERLRGVSRMESLDLILKGAAQVYSPEAKEELAARKNRYYVQLLQLLTPADILPGVTALLQELKDRGVGCAIGSSSKNTPFILEKIGLGGFFDAVADGNQIRRSKPDPEVFLLAAEKLGLRAEQCVVVEDAEAGIEAALAAGMKAAAVSAAANYPGAHVRGADLREIGVGQLLQD
>NC_015690.1|WP_013915833.1|2227310_2229029_+|beta-N-acetylglucosaminidase
MKELQTRLQAKPFYLNEEQIRWVEATLSGMTMEEKIGQLFCLIGYTSNEGYLKNLAQNVKIGGLMCRQMPAAEVIDTVRILQENAQIPLLISANLESGGSGIAKEGTVFGSPLQVAATDDDGMAYRLGVVCGREGAAVGANWAFSPIVDIDYNFRNPITNTRTFGSDPERVRRMGVQFVKGLQENGVAASIKHFPGDGLDERDQHLVTTVNDMDCEAWDATYGAVFRDCIEAGAMSVMIGHIMQPAYSRKLSPGIRDEDILPASLSYEITTKLLKEELGFNGLVITDSTTMAGMVIPMPRSQSVPRTIAAGCDMFLFTRNFEEDYGYMKQGVADGIITEERLNDAVTKILAMKAALHLPQKKAEGTIVPSPERAGEILGAEEHRQWADACADRSVTLVKEEAGVLPISPAKYRKVLLYGIETTGGFFEAKESAAGIIKAKLEKEGFTVDLFNPNRGMEGMMVPYSEVKDNYDLILYIVNLATKSNQTVVRIEWAFPMGANVPIYMSSVPTVFVSVENPYHLLDVPRVRTYINTYNSAEHTLDALIDKLTGRSGFHGKSPVDPFCGKWDARLS
>NC_015690.1|WP_013915834.1|2229089_2229371_+|HPr-family-phosphocarrier-protein
MIRQSFIITDQDGFHARSANDLVYTANRFLDCALFAEHGGKRVTLHSILGVLSLSVRPGDELLLSADGGHEAEAMEALQGVMIRERIGRSNEE
>NC_015690.1|WP_013915835.1|2229384_2230491_+|alpha/beta-hydrolase
MRQYDKKLLTLLKERVTIRTTEHLTYMEKKIPDSEGAGELDPRVLQLMMEGAAKSGGGAAGFPDLSEVRPETFPIGAIRTGMGFPNKDLTETKVSVELLKIEGEGGEIPIRIYRPAVTGLLPAVVFFHGGGFIGGSPDVVENPCRSLAEKAGALVVNVDYRLAPEHPFPAGVLDCYDAVQWVYRHADELGVDPSRIAVAGDSAGGNLAAGCAQMDRDSGSGMIRMQALIYPVLLIGESAAYPWRLEEYEIHRHQEYILPGLEALRGAGQLFQALYLQGHDPANPLVSPLLQESVEKLPETLIVTAEYDMLRLEGEAYAGRLAEAGVRTRLIRYKGMDHAFLDKYGIYPQAEDCIDEIASMMGRLSSSL
>NC_015690.1|WP_014369658.1|2230554_2232066_-|mannan-endo-1,4-beta-mannosidase
MKKTLMLFTLASLLVSGMPAAYAHTAAPVDTSASQKTKDTYNWLTHLPNRTDNKVVSGFFGGYSNNGFSTTQLEELKTAAGQYPGIFGCDYGAGWASASDPTALIDYTCNSTLKSYSTSGGLITVNVHYPSPGYSTGGNLNTKLTNFSDLTNPSTVTGQRWRSYLDKTAAGLKDLQDAGVTVLWRPFHEMNGDWFWWGNQDAAAFKAAWIDMYNYFTNTKGLHNLIWIYAPDFSRDNRTAYYPGGSYVDIVGLDAYDDNPETAVTGYDELVALGKPFAFTEIGPDTFGTFDYTKWLNAIKTKFPKTVYFFAWNDNWAPHRNQNASALFNDSWIVNRGEITLSSITEGGTTTPGTATTLYNFEGSTESWTGTNVTGGPWTTTEWKASGSSSLKADVNLGAAVKNYTLSRATAQNLSSKSTLKASVSRASWGTGTLTAKLFIKTGSTYQWYDGGAVTVPATGTTLSLSLAGLANLSDVREIGVQFTAASGSSGTSAIYVDNVTVE
>NC_015690.1|WP_013915837.1|2232661_2233534_+|sugar-ABC-transporter-permease
MNVSYNTQRTIILVSFLTVPLLLLLTFSYYPLLSLFYYSFLEWDGLTEKAFVGFQNYREIFGNAEYFGVLKNNAYYFIGGLLQTGLALYFAVLLNSKLKGRNGFRVILFLPYIMHSVAIVFMFQALYNNQYGTLNAFLDLVGLSGWKQNWLGDPSIVNFSLAFVSMWKYMGLSMVIFLGTLQSIPQDIYEAARIDGASSTQQFLHVTLPSIRKVMELLLLLTLTGALEAFEIPYIMMLGANNTETFIIKTVDVAFKFQQVGLGSALAVVMLLIVLVFVGLQRLLLKGGDE
>NC_015690.1|WP_013915838.1|2233534_2234368_+|carbohydrate-ABC-transporter-permease
MREQSVFVRTIQYLSLFIGVFVVLFPPYTVFITSLKTKQEYLQNRFALPANWLHWENYEFIFTKTKILTTAFPNTLYIIGLSVAGNIILGTMVAYALGRFDFKLKKVIIGMYLLASVTPLVTTQVATYGLMNSLGLINNIHAPILLYLGADVISIIIYLQFIRNISYSLDESAMLEGASLFRIYWNIIFPLLMPATVTVMILRTIYIYNDFYIPFLYMTKTNLQVVSTSIFQFVGPNAASWNYIAAMIIVIFIPAIILFLFLQKFIYAGVTSGSVKE

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Crispr_ID: NC_015690_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015690_11

2363426-2363515

Orphan

Consensus_repeat	Method
CCGATCAGGTCGCTGGATAAGCC	CRISPRCasFinder

1 spacers

WYL

The CRISPR arrays of NC_015690_11

>merge|NC_015690|11|2363426-2363515|CRISPRCasFinder
CCGATCAGGTCGCTGGATAAGCCACGGGCCGGGTCACCGTTCAACTGATAAGCCACTGGCCCTGTTACCGGTCAGGTCGCTGGATAAGCC

>NC_015690|11|8|2363426-2363515|CRISPRCasFinder
CCGATCAGGTCGCTGGATAAGCC	ACGGGCCGGGTCACCGTTCAACTGATAAGCCACTGGCCCTGTTA
CCGGTCAGGTCGCTGGATAAGCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015690.1\|WP_013915948.1\|2370327_2372577_-\|glycoside-hydrolase-family-127-protein	unknown	unknown	gnl\|CDD\|369609
NC_015690.1\|WP_013915940.1\|2360954_2361860_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226666
NC_015690.1\|WP_013915947.1\|2369509_2370193_+\|epimerase	unknown	unknown	gnl\|CDD\|187560
NC_015690.1\|WP_013915950.1\|2372750_2373644_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NC_015690.1\|WP_013915939.1\|2360277_2360709_-\|PilZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|377796
NC_015690.1\|WP_081473175.1\|2376354_2377032_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340879
NC_015690.1\|WP_013915941.1\|2361881_2362775_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_015690.1\|WP_013915946.1\|2367628_2369284_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270298
NC_015690.1\|WP_013915931.1\|2354534_2355158_+\|carboxypeptidase-regulatory-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|379297
NC_015690.1\|WP_013915944.1\|2364044_2365811_+\|histidine-kinase	unknown	unknown	gnl\|CDD\|225519
NC_015690.1\|WP_013915954.1\|2379025_2380258_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340883
NC_015690.1\|WP_041616786.1\|2377418_2378873_+\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NC_015690.1\|WP_013915945.1\|2365795_2367457_+\|response-regulator	unknown	unknown	gnl\|CDD\|381091
NC_015690.1\|WP_013915934.1\|2357467_2357746_+\|DUF2277-domain-containing-protein	unknown	unknown	gnl\|CDD\|378364
NC_015690.1\|WP_013915938.1\|2359480_2360260_-\|exodeoxyribonuclease-III	unknown	unknown	gnl\|CDD\|197321
NC_015690.1\|WP_013915933.1\|2356488_2357445_+\|YafY-family-transcriptional-regulator	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|225253
NC_015690.1\|WP_013915951.1\|2373728_2375282_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NC_015690.1\|WP_143768121.1\|2357908_2358853_+\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013915937.1\|2359067_2359319_+\|DUF1272-domain-containing-protein	unknown	unknown	gnl\|CDD\|377732
NC_015690.1\|WP_013915932.1\|2355556_2356375_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669

Protein	Function_ID	Function_description	E-value
NC_015690.1\|WP_013915948.1\|2370327_2372577_-\|glycoside-hydrolase-family-127-protein	gnl\|CDD\|369609	pfam07944, Glyco_hydro_127, Beta-L-arabinofuranosidase, GH127. One member of this family, from Bidobacterium longicum, UniProtKB:E8MGH8, has been characterized as an unusual beta-L-arabinofuranosidase enzyme, EC:3.2.1.185. It rleases l-arabinose from the l-arabinofuranose (Araf)-beta1,2-Araf disaccharide and also transglycosylates 1-alkanols with retention of the anomeric configuration. Terminal beta-l-arabinofuranosyl residues have been found in arabinogalactan proteins from a mumber of different plantt species. beta-l-Arabinofuranosyl linkages with 1-4 arabinofuranosides are also found in the sugar chains of extensin and solanaceous lectins, hydroxyproline (Hyp)2-rich glycoproteins that are widely observed in plant cell wall fractions. The critical residue for catalytic activity is Glu-338, in a ET/SCAS sequence context.	0
NC_015690.1\|WP_013915940.1\|2360954_2361860_+\|sugar-ABC-transporter-permease	gnl\|CDD\|226666	COG4209, LplB, ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism].	3.13002e-120
NC_015690.1\|WP_013915947.1\|2369509_2370193_+\|epimerase	gnl\|CDD\|187560	cd05250, CC3_like_SDR_a, CC3(TIP30)-like, atypical (a) SDRs. Atypical SDRs in this subgroup include CC3 (also known as TIP30) which is implicated in tumor suppression. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine rich NAD(P)-binding motif that resembles the extended SDRs, and have an active site triad of the SDRs (YXXXK and upstream Ser), although the upstream Asn of the usual SDR active site is substituted with Asp. For CC3, the Tyr of the triad is displaced compared to the usual SDRs and the protein is monomeric, both these observations suggest that the usual SDR catalytic activity is not present. NADP appears to serve an important role as a ligand, and may be important in the interaction with other macromolecules. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.64718e-25
NC_015690.1\|WP_013915939.1\|2360277_2360709_-\|PilZ-domain-containing-protein	gnl\|CDD\|377796	pfam07238, PilZ, PilZ domain. PilZ is a c-di-GMP binding domain which is found C terminal to pfam07317. Proteins which contain PilZ are known to interact with the flagellar switch-complex proteins FliG and FliM. This interaction results in a reduction of torque generation and induces CCW motor bias. This domain forms a beta barrel structure.	9.12774e-07
NC_015690.1\|WP_081473175.1\|2376354_2377032_-\|MFS-transporter	gnl\|CDD\|340879	cd17321, MFS_MMR_MDR_like, Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.66659e-23
NC_015690.1\|WP_013915941.1\|2361881_2362775_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	1.86554e-62
NC_015690.1\|WP_013915946.1\|2367628_2369284_+\|extracellular-solute-binding-protein	gnl\|CDD\|270298	cd13580, PBP2_AlgQ_like_1, Periplasmic-binding component of alginate-specific ABC uptake system-like; contains the type 2 periplasmic binding fold. This subgroup includes uncharacterized periplasmic-binding proteins that are closely related to high molecular weight (HMW) alginate bining proteins (AlgQ1 and AlgQ2) found in gram-negative soil bacteria. The HMW alginate uptake system is composed of a novel pit formed on the cell surface and a pit-dependent ATP-binding cassette (ABC) transporter in the inner membrane. The transportation of HMW alginate from the pit to the ABC transporter is mediated by periplasmic HMW alginate-binding proteins (AlgQ1 and AlgQ2). Alginate is an anionic polysaccharide that is made up of alpha-L-mannuronate and its 5'-epimer, alpha-L-guluronate. Alginate is present in the cell walls of brown seaweeds, where it forms a viscous gum by binding water. Alginate is also produced by two bacteria genera Pseudomonas and Azotobacter. AlgQ1 and AlgQ2 belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. However, unlike other bacterial periplasmic-binding proteins that deliver small solutes to ABC transporters, AlgQ1/2 can bind a macromolecule and may have specificity for either sugar or a certain type of polysaccharide.	1.10168e-113
NC_015690.1\|WP_013915931.1\|2354534_2355158_+\|carboxypeptidase-regulatory-like-domain-containing-protein	gnl\|CDD\|379297	pfam13620, CarboxypepD_reg, Carboxypeptidase regulatory-like domain.	0.0088218
NC_015690.1\|WP_013915944.1\|2364044_2365811_+\|histidine-kinase	gnl\|CDD\|225519	COG2972, COG2972, Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms].	2.03859e-42
NC_015690.1\|WP_013915954.1\|2379025_2380258_+\|MFS-transporter	gnl\|CDD\|340883	cd17325, MFS_MdtG_SLC18_like, bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters. This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	8.10436e-25
NC_015690.1\|WP_041616786.1\|2377418_2378873_+\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	2.97335e-59
NC_015690.1\|WP_013915945.1\|2365795_2367457_+\|response-regulator	gnl\|CDD\|381091	cd17536, REC_YesN-like, phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators. This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	7.62462e-36
NC_015690.1\|WP_013915934.1\|2357467_2357746_+\|DUF2277-domain-containing-protein	gnl\|CDD\|378364	pfam10041, DUF2277, Uncharacterized conserved protein (DUF2277). Members of this family of hypothetical bacterial proteins have no known function.	3.01344e-35
NC_015690.1\|WP_013915938.1\|2359480_2360260_-\|exodeoxyribonuclease-III	gnl\|CDD\|197321	cd09087, Ape1-like_AP-endo, Human Ape1-like subfamily of the ExoIII family apurinic/apyrimidinic (AP) endonucleases. This subfamily includes human Ape1 (also known as Apex, Hap1, or Ref-1) and related proteins. These are Escherichia coli exonuclease III (ExoIII)-like AP endonucleases and they belong to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds. AP endonucleases participate in the DNA base excision repair (BER) pathway. AP sites are one of the most common lesions in cellular DNA. During BER, the damaged DNA is first recognized by DNA glycosylase. AP endonucleases then catalyze the hydrolytic cleavage of the phosphodiester bond 5' to the AP site, and this is followed by the coordinated actions of DNA polymerase, deoxyribose phosphatase, and DNA ligase. If left unrepaired, AP sites block DNA replication, and have both mutagenic and cytotoxic effects. AP endonucleases can carry out a variety of excision and incision reactions on DNA, including 3'-5' exonuclease, 3'-deoxyribose phosphodiesterase, 3'-phosphatase, and occasionally, nonspecific DNase activities. Different AP endonuclease enzymes catalyze the different reactions with different efficiences. Many organisms have two AP endonucleases, usually one is the dominant AP endonuclease, the other has weak AP endonuclease activity; for example, Ape1 and Ape2 in humans. Ape1 is found in this subfamily, it exhibits strong AP-endonuclease activity but shows weak 3'-5' exonuclease and 3'-phosphodiesterase activities. Class II AP endonucleases have been classified into two families, designated ExoIII and EndoIV, based on their homology to the Escherichia coli enzymes exonuclease III (ExoIII) and endonuclease IV (EndoIV). This subfamily belongs to the ExoIII family; the EndoIV family belongs to a different superfamily.	4.84518e-153
NC_015690.1\|WP_013915933.1\|2356488_2357445_+\|YafY-family-transcriptional-regulator	gnl\|CDD\|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	2.03314e-66
NC_015690.1\|WP_013915951.1\|2373728_2375282_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	2.22579e-42
NC_015690.1\|WP_013915950.1\|2372750_2373644_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	1.29272e-27
NC_015690.1\|WP_013915937.1\|2359067_2359319_+\|DUF1272-domain-containing-protein	gnl\|CDD\|377732	pfam06906, DUF1272, Protein of unknown function (DUF1272). This family consists of several hypothetical bacterial proteins of around 80 residues in length. This family contains a number of conserved cysteine residues and its function is unknown.	2.58984e-20
NC_015690.1\|WP_013915932.1\|2355556_2356375_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.76643e-28

>NC_015690.1|WP_013915941.1|2361881_2362775_+|carbohydrate-ABC-transporter-permease
MHHISAPYRWFLRFNYAVLTVLALLCLFPLVNILAISFSSSGAVAAGKVTFWPVDWTLSSYTYMMENRQFTGSFLISLTRVALGTAVNLILTILVAYPLSKDARTFRSRTAYAWIFVFTMLFGGGLIPTYLVVKETGMLNSVWALILPGAVPIFNVLLMLNFFRGLPKELEEAAWMDGAGHFRTLWSVYLPVSLPSIATVTLFTVVGHWNAWFDGMIYMKSPEHYPLATYLQSMLQQQLNVTTTTGMSLEEADRLSRVSDRTTQASQIFLSVVPILVLYPFLQRYFVKGLVVGSVKG
>NC_015690.1|WP_013915940.1|2360954_2361860_+|sugar-ABC-transporter-permease
MNANLKGFVRNIPLHLMLVPGLIVILIYNYIPMAGLIIAFQDFSPIGGFRVMNWVGLDNFKYLFELPGFYQVVWNTVFISVMKIIAGLTVPVLVALLLNEVRSSGFKRSVQTIIYMPHFFSWVVLAGILIDVLSPSGGLVNMALKAAGYPPIQFLASNDWFPYVLVISDQWKEFGFGTIIYLAALTSIDSSLYEAAVMDGAGRWKQTWHITLPGIRPIMILMLTLSLGNVLNGGFDQVFNLYNPLVYESGDILDTMIYRIGLQDAQYSVSTALGLIKSVVSFLFIGLGYYLAYRIANYRIF
>NC_015690.1|WP_013915939.1|2360277_2360709_-|PilZ-domain-containing-protein
MSHENRQHQRSTTALDLSLSIHSIQNKETKTRRTFIELKDISLTGLSFKCSLNFPAHGDYVLKFENALFGEMHGKIVWKEHTETGFLYGVQFLSISNALNRFLTHESLTGEHRLRTQAAVMTKPWSARYEAVPQPVPSNHSQQ
>NC_015690.1|WP_013915938.1|2359480_2360260_-|exodeoxyribonuclease-III
MKLVSWNVNGLRACVNKGFSEYFAQTDADIFCVQETKLQEGQIALDYPDYHQYWNYAEKKGYSGTAVFTKVKPLSVRYGLEEDSEPEGRIITLEFDGFYLVTVYTPNAKRDLSRLDYRLEWEDRFRRYIAGLDAVKPVILCGDLNVAHEEIDLKNAKGNRGNSGFTAEERQKMTDLLGAGFIDTFRHFYPEQTDAYTWWSNMPKVRERNVGWRIDYFLASARLAPSLQDAQIHAHVLGSDHCPVVLTLAEVPQAAAARV
>NC_015690.1|WP_013915937.1|2359067_2359319_+|DUF1272-domain-containing-protein
MGLEMRDRCETCTKALDRTSTAYICTHECTFCPECTEAVHHVCPNCGGELVKRPRSGPAVTSCPFRSQSVHSAAGHAGYRIPD
>NC_015690.1|WP_143768121.1|2357908_2358853_+|hypothetical-protein
MRKKERGVNKLKLFSIILIVWIVAGCSGAEASKESAGQENALPTPTQQPKPVNLQPEEERKKEAVRSFGYVVMDGYYYRVTGETVDDAVIGKVIGEIKRVGDWEIKRSGDSNEYPPGPLYSIQEKDTKEVIAYRLPKKKGDPGPYRYSVLERSEQVEQHDPKQIMGAKNDPEEVGIALQNIRKAVPYLYEFDSNLKSAVVNQAGYSSNTGVTLYYRVSEADDKEIQGFLFIFEYPQEKAALIMNSAFSANIGGEPRSPAKASETFEMNGIQWSYYGTHLLRGEKDGHYYELQTQGKFTRDRLVGLLKHFNNNEQ
>NC_015690.1|WP_013915934.1|2357467_2357746_+|DUF2277-domain-containing-protein
MCRNIKTLFNFEPPATEEEIQAAALQFVRKISGFQTPSKANADAFHLAVEEVTAAARKLMGTLVTQAEPRSREAEAERARARNAKRFGTGEE
>NC_015690.1|WP_013915933.1|2356488_2357445_+|YafY-family-transcriptional-regulator
MSKSKRLMELMMAVNRKRKFTVKELAGEFGVSPRTILRDLQELSELGVPLYSEVGPHGGYQVLKQRILPPIAFSEDEAVAVFFAVHALRHYASLPFETESSSALNKFYYYMPQDTRERIDQMKQRVDFVTPARQASSPYLSLLLEAAIRQQVLLVDYESRGQRSRRELQPVGIYTRDGLWYCPAYCFRSGELRMFRCDRMHAVEPSDTEPVELRHVHLENRLHEQRAPVEQEAVTILAELTPAGVQACEAAPWPDPRLHLREDGSGWLEGEIAKRDLPYFAQFFIGLGLDITVKQPPELLEAIRTKLAELTAKYKPCK
>NC_015690.1|WP_013915932.1|2355556_2356375_-|alpha/beta-hydrolase
MLSVQTYHPCGVRKCFPSGSLRLSYLDYGGESDNVLLLLHGHMGNARTFSEVAAKFADWRVISLDQRGHGWSEHPEDRDYSRESYNGDILAFIRTVLGGRPVTLLGHSLGGLNAYQFAARYPELVKAVIVEDIGAEIQADLSFAGKLPERTGSLRELREALKQAGLKSIDYFIEGSFEDERGWGLRCDLPGMRISQENCNGEWWDDWLSSACPILLIHGRHSFVMDEAQAERMVSRRPGARLAVFDTGHGVHTDDLGGYCRAVREFLEGLPV
>NC_015690.1|WP_013915931.1|2354534_2355158_+|carboxypeptidase-regulatory-like-domain-containing-protein
MTAFTFLKQTTCVVLGVFLLSGTSVLAASEKSVPEQLASMVAQIQELSKKIDLFEHTLVKKSDFEALKQTVAAQQKAIDELRNNNHPTPPSQAPVVKFKLKVTDNVWELTPLPNIRVIVNDATGTKRYTAISGADGKVAFDLPPGQYWYTYEVLDANGDVIETTAVRNMLEGNVYVDQAAMLEWNNMEKLLSVPMIFYTDPQYVKQD
>NC_015690.1|WP_013915944.1|2364044_2365811_+|histidine-kinase
MIQLKRLLHILGSRSIVAKLMAAFLLVVLPLCICSIWITYNSSKQMQQEIERANESKLHFYYSHLEFELNRITALVTEYAFDETLSTFSTRIPIMSPYEKAANLNWIHTKLKQIRETSPYIGDVVYYVPRIGKRVSAQEGITDVPAEQWQGLIYSMGNLKGALSQYGGELYMLRSNPFNIDRETPPDFLLGVRLSSAELERRLKEFAVSGESDITLLFGRGSDYVVSSSSDYQSLGLGEERAQEPAVKVQQRRTEEYLHYTIFDRDNHFRLTASIPNDVVMRPIQVYSQWLLLLSAGSVVIVIFFSFWIYRTLHRPLTVLVKGFKKAEQGDMKVKLNPSRQDEFGYLYARFNEMMEHLHALIEENYIQRIRTGEAELKHLQSQITPHFLYNSLFSIKQMAELENVELIKEFSDYLGQYFRYMTRDAAAEVSLGQEVDHALVYLAIQRIRFGSRLRAEVEELPAEYRSIRVPRVLLQPLIENVFEHGLRQKHSDGLLRLSYAREESGLVIRVEDNGDGLGGDMIEELSRRLGGTGPAEGERTGLLNVNERLRIRFGPGYGIRVERSRLGGLSVCLHLPAEGEMESCAAC
>NC_015690.1|WP_013915945.1|2365795_2367457_+|response-regulator
MRRMLIVDDEPLIADGLHAYFGKAELEDLEVIKVYSASEAIEWLNLVKIDIVLSDICMPGMDGMALIQEIGDRWPRCKIILLTGHNEFDYAHRAIRNPCVVDYLLKTEGMDRIRSVVEQTLELLASEQDFHTQAQWFRDKLPRALPQLQKQLLFDIVRRSEWKDRLSLQEEFEAVHLPFRAELAVLPLLLRIEEWRSYESDSDRSLIRYAAANIAEELLGDKSVAKAFELDRQTVACFVQPQADPLRPGGESERWARTVRFVHGTMESVQQACGECLHLSVSLIAGESPVGWSELYGALSRLGLSVVGSPGLGMEKLVRVDLTPASAPPSRSEAYPAMSELLLDNLKQELLQGREDWAPALRRWMEAAGAEGPQDPFVKLRLIGGIGECLLQTLQELGLSPEQDGEMDLTPMLRFGVHTGWAELLAFYEAAFRWIVSRRSDTYKSSELQVLSAIHSYIKSHLKEDLSLTRIAQEVSLNPSYLSRWYKRVTGKGLSDYILEKKIERSKELLLGSSAKMYEISEEVGFSDQHYFFRFFKKAVGCTPQEFRDGRKL
>NC_015690.1|WP_013915946.1|2367628_2369284_+|extracellular-solute-binding-protein
MRENGRRLKRLALAMVLPLAVTACSQSGEPKTAGETPPNEAGSAEKQGGPLTKYDPPITIRATMNETGKDTLAQGDTHENNVWTRGYEKELGIKVKYDWIVADANYNDKMNVTLASGDLPDLLKVSPVQFEQLQQAGMLEDLTEVYNTYASDLVKEFYAAENGAALKPVTKDGKIYAMVSYPGALDSSDMIWVRQDWLDKLGLGAPKSMQDVIKIAEAFTNNDPDGNGQKDTYGIQLNKDLPINAFLLGYHAYLETWFKDGSGKLVNGTVQPEVKKGLAELQRLYKAGAIDPEFGVKDFAKSMEAINAGKAGMFFLPQWAPFPVKEMIKKDKNVNWVPYPVQSIDDKPAKTQNHQTLAGVFAVRKGYEHPEALIKLLNFQAEKMFGESAKTERAGYLNGLTGTGWQNAVVSNLPANKNVKAMEEVVQALDSGDTSKLGLEAKLFYEDIQAYRKGDLDKWHMERIFGPLSSQAVIKHYRDNNLVVMNEFIYAPTKTMSSKQATLDKLRAETFLKIIYGDLPVDDFDKFVENWKKLGGDQITEEVNKTVQANK
>NC_015690.1|WP_013915947.1|2369509_2370193_+|epimerase
MKIIIFGATGMVGQSALRECLLNDEVQEVLTVGRKPAPQQHKKLKQRVLENLTDLAGIKEEVTGWDACLFCLGVSSAGMKEEEYRRITYDLTLSAAETLAGLNPQMTFIYVSGSGTDNSESGRSMWARVKGETENALLRLPFKAAYMFRPGVILPVYGVTSKTKWYQTLYDVMRPLNPMLIRLKSVITSEQLGQAMIHVSLQGYDRPIIESYELKEISMKAQQRSET
>NC_015690.1|WP_013915948.1|2370327_2372577_-|glycoside-hydrolase-family-127-protein
MNTQAFDLHKVRIESGPLKHAMELNASYLLNLEADRLLSRFREYAGLAPKAPHYEGWESRGISGHTLGHYLSGCALMYASTGREELLSRVNYVVEELQQCQRADGSGFISGIPRGKELFQEVKAGDIRSQGFDLNGGWVPLYTMHKLFAGLRDAYLLAGSRKALEIEIKLGLWLDDVFSGLSHEQVQRVLHCEFGGMNEVLTDLAVHSGDDRFLKLAERFWHGEVLGDIAERKDTLGGRHANTQIPKIIGAARQYEVTGEERYAGISRFFWDRVVNHHSYVIGGNSYNEHFGEPDKLNDRLGEGTCETCNTYNMLKLTRHLFQWDALAAYADYYERAMFNHILGSQQPVDGRVCYFVSLEMGGHKSFNSQYEDFTCCVGSGMESHSLYGSAIYFHNGSALFVNQFVPSTVEWEEQGVRLTQETAFPENGRGVLRIRTAKPGTFAVKVRYPSWAEPGISVKVNGQAVSADARPGGYVTVEREWQDGDTLEYDFPMTLRIESMPDNPDRIALLYGPLVLAGDLGAIDAPQDGERALASVLIGEREELLAGLRPVEGKPNTFLLQGIAYAGDLELRPFYRMYDRRYTVYWDLFTREAWAAAESGYRAAVEYNVQLEARTVDFVQPAEMQPERDHDFQGEHVGLGSIHNRKYRDTWPSGWFSFAMKVLPEEPVELAVTYLKTSQPAGGFDLLADGRVLGGGRLESEELGKLETLVYELPQELTAGKTSITIKFAAHQGRKVAQVAGLRIVKRL
>NC_015690.1|WP_013915950.1|2372750_2373644_+|helix-turn-helix-transcriptional-regulator
MSCLKISIDTPVRFLAAGEFISETPWTHAARSMGCYELIIGVSETVYLREEDMRFEVGPGDALLLRPGLAHGGYRASPPGVKFYWFHFDCPQGAQWLTAPAMKRTAEEIQARAHRAWSVGEVYLPQHLHIEQKERIGILVSQILHVANANYLTAHSVNYLLTSLFIEISEQVLAPTPARGARMQGDAQFIKMAEWTRIHAEEPLTVSALAAKFNYNKDYLTRLFKQHTGMGPLDFIHSVRIAKAKELLSRTALSVREIAAEAGYPDDKYFMRLFRQHTNMTPTQYRNAYHKTFMNNV
>NC_015690.1|WP_013915951.1|2373728_2375282_+|HAMP-domain-containing-histidine-kinase
MLSWNRTRLMAAAMIGLSFLNLIFVLYVLSGIRTDIHEAINDRRHKIAMNNRFWSGFLLHDKTLEYYIAYPHKTELGGRIRELREQETEQLDRLDAILKYQPSREALMQLRAQHTHYLEIEEAILKRTAEGETGQASQLFHEQLHPLTYEMQLSIETLGTYQENLMDSVLEEIRSTRLSMVILVTISLLLSLAFVLVLRVFRRKEADLQQLTALLKKLPQEGQELSYVNLDHDSADEFKVIARTFNELSNRLEEKNQLLTLSSQQKKNILGVLSHELRTPLNSIIGLSDMLAQDESNADREFAHLIHRSGTELLGTINDLLDLSAAVQGTLEAEAGPVNLRAFAETLDGYFRPFALQKGLDFTVRVEAGVPEIFYTDERMLQRILVHLLSNAGKFTERGGVSLTIRGMEQEDREAAFPVSAASAVSISVSDTGAGIAEDQRSRIFQLFHAPDQYMTRQQGGIGVGLSLCAEFVKILGGELRLASREKEGSTFTLLIPTLAEESLAIDAPASQEAGVD
>NC_015690.1|WP_081473175.1|2376354_2377032_-|MFS-transporter
MGTARNPFVRPVLFKNKFYVNSVVVAFLSAFAYFAVLVYVPLLNLEVNQLTPGEAGLTLLPGGAAVALLSPWVGRISDRVGTKSLIVTGLIVMGISTFFLSRFASGASPIMSSVGVMGAGIAFALVNSPATNSAVGVLQKDMVGVGMGFFQGALYLGAGTGASLIGAFLHARRDANFPLNPMYSLDAVNYSDSFLVVTIAVIIALIASIGLKNDKQGSRIVKPSK
>NC_015690.1|WP_041616786.1|2377418_2378873_+|serine-hydrolase
MNTAKNKIMICISSVLLLVSILVTPVTAIEAREKAEIVQEIDDYVKRNMKVNKINASALAIVSKNEIFYTNGYGVYPDGRQITSSTPFPIASLSKAFTALAVLQLVEKGRIHLDTPYAAYFPELSPMDERVHKITVRNLLNHTSGLTDKVNPDMTRDLQYQSLREINQSLNTVKLVNEPGTAHFYHNPNYQYLALLVEKVSGQSFSSYMKQYIFEHLGMRSTFSISTTQQINENSAIPGGNYLLLGFPVRQAEPHWFIDGPAGIISSAEDMAKWMLAQCSGVLLTSELAEEYHTAGQRGPYGMGWVVEEDEHMGRTISHSGTFWTYKSEEKIYLDQQIGVTMMFNSGINTFVDYRAFIEGIVRILRGEMAEVPNFNSRNMDTVMILLLIVTVLWGIYTYFRICKSSKSITIGKLFFLSVWRLLPILILLLLSPILTFMAAGRVLPWFGLWITMSSLMIWLVVLSIINIIHAICHIRRKSHAGNH
>NC_015690.1|WP_013915954.1|2379025_2380258_+|MFS-transporter
MFGFSRLPQNARGCLLYEPLFLIPYSMFSTYATIYMFEMGMSETAIGWVTTLTLLVQVFSSFISGYLTDRLGRKGALLYFDLLSWTVGTLLWAVSQNIWFFIAAAVVNGFQRVPHTAFYCLLVEDTESKDRTFVFSILQFVAMLGGLFAPLGGLLVAQYGLVPGMRVMYVLACVCMTIQFVGRHFATRETQIGLRKMAETRSVSLMAGLREYKGVFRSMAGNKPLMMIFGVYILFQFQLTMKGTYLSLYLVDDLKLDSGLVSIFPAVTSMIMLLSMWLLRRQSDQGLHTVMLWGFFISLVSNLILILPLPGMMFWLILSTVLAAAGTMMTYPYLEAAVANAIDDENRASIFAMLSVLILLVVSPSGIIGGGAYRLDPSLPFLLIVLSFAASIALLVLYKRSVGREEPSSA

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Crispr_ID: NC_015690_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015690_12

2453138-2453230

Orphan

Consensus_repeat	Method
TGCCGCTGTAGGCGGTGCCGTACTTCG	CRISPRCasFinder

1 spacers

WYL

The CRISPR arrays of NC_015690_12

>merge|NC_015690|12|2453138-2453230|CRISPRCasFinder
TGCCGCTGTAGGCGGTGCCGTACTTCGCCTGGAGCACCCCAACGCCGGGCGAGGTGACGGTGCTTCTGCCGCTGCAGGCGGTGCCGTACTTCG

>NC_015690|12|9|2453138-2453230|CRISPRCasFinder
TGCCGCTGTAGGCGGTGCCGTACTTCG	CCTGGAGCACCCCAACGCCGGGCGAGGTGACGGTGCTTC
TGCCGCTGCAGGCGGTGCCGTACTTCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_015690.1\|WP_013916016.1\|2447467_2448799_+\|sugar-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270303
NC_015690.1\|WP_014650547.1\|2456981_2457425_-\|ribonuclease	unknown	unknown	gnl\|CDD\|238471
NC_015690.1\|WP_013916022.1\|2453909_2454560_-\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013916030.1\|2458784_2459480_+\|LysE-family-transporter	unknown	unknown	gnl\|CDD\|280058
NC_015690.1\|WP_041616793.1\|2454692_2455637_+\|YafY-family-transcriptional-regulator	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|225253
NC_015690.1\|WP_013916019.1\|2450768_2452751_+\|glycoside-hydrolase-family-127-protein	unknown	unknown	gnl\|CDD\|226063
NC_015690.1\|WP_013916014.1\|2446303_2447194_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NC_015690.1\|WP_013916017.1\|2448855_2449815_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NC_015690.1\|WP_013916021.1\|2452939_2453086_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226063
NC_015690.1\|WP_013916029.1\|2458383_2458758_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319909
NC_015690.1\|WP_187296742.1\|2452732_2452888_+\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013916031.1\|2459514_2460372_+\|phosphotransferase	unknown	unknown	gnl\|CDD\|366736
NC_015690.1\|WP_013916028.1\|2457620_2458115_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|128898
NC_015690.1\|WP_013916018.1\|2449819_2450647_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_015690.1\|WP_013916024.1\|2455650_2455968_+\|TfoX/Sxy-family-protein	unknown	unknown	gnl\|CDD\|377439
NC_015690.1\|WP_013916011.1\|2444182_2444386_+\|cold-shock-protein	unknown	unknown	gnl\|CDD\|224197
NC_015690.1\|WP_013916013.1\|2444874_2445984_-\|GAI-protein	unknown	unknown	gnl\|CDD\|335361
NC_015690.1\|WP_013916032.1\|2460396_2460897_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379228
NC_015690.1\|WP_013916012.1\|2444478_2444715_+\|cold-shock-protein	unknown	unknown	gnl\|CDD\|372943
NC_015690.1\|WP_014369765.1\|2456205_2456871_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377924

Protein	Function_ID	Function_description	E-value
NC_015690.1\|WP_013916016.1\|2447467_2448799_+\|sugar-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270303	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold. This family includes the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.881e-92
NC_015690.1\|WP_014650547.1\|2456981_2457425_-\|ribonuclease	gnl\|CDD\|238471	cd00933, barnase, Barnase, a member of the family of homologous microbial ribonucleases, catalyses the cleavage of single-stranded RNA via a two-step mechanism thought to be similar to that of pancreatic ribonuclease. The mechanism involves a transesterification to give a 2', 3'-cyclic phosphate intermediate, followed by hydrolysis to yield a 3' nucleotide. The active site residues His and Glu act as general acid-base groups during catalysis, while the Arg and Lys residues are important in binding the reactive phosphate, the latter probably binding the phosphate in the transition state. Barstar, a small 89 residue intracellular protein is a natural inhibitor of Barnase.	2.09999e-46
NC_015690.1\|WP_013916030.1\|2458784_2459480_+\|LysE-family-transporter	gnl\|CDD\|280058	pfam01810, LysE, LysE type translocator. This family consists of various hypothetical proteins and an l-lysine exporter LysE from Corynebacterium glutamicum which is proposed to be the first of a novel family of translocators. LysE exports l-lysine from the cell into the surrounding medium and is predicted to span the membrane six times. The physiological function of the exporter is to excrete excess l-Lysine as a result of natural flux imbalances or peptide hydrolysis; and also after artificial deregulation of l-Lysine biosynthesis as used by the biotechnology. industry for the production of l-lysine.	9.2881e-17
NC_015690.1\|WP_041616793.1\|2454692_2455637_+\|YafY-family-transcriptional-regulator	gnl\|CDD\|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	2.83101e-56
NC_015690.1\|WP_013916019.1\|2450768_2452751_+\|glycoside-hydrolase-family-127-protein	gnl\|CDD\|226063	COG3533, COG3533, Uncharacterized protein conserved in bacteria [Function unknown].	0
NC_015690.1\|WP_013916014.1\|2446303_2447194_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	6.29298e-24
NC_015690.1\|WP_013916017.1\|2448855_2449815_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	1.23408e-99
NC_015690.1\|WP_013916024.1\|2455650_2455968_+\|TfoX/Sxy-family-protein	gnl\|CDD\|377439	pfam04994, TfoX_C, TfoX C-terminal domain. TfoX may play a key role in the development of genetic competence by regulating the expression of late competence-specific genes. This family corresponds to the C-terminal presumed domain of TfoX. The domain is found associated with pfam00383 in Neisseria meningitidis TadA. It is also found as an isolated domain in some proteins suggesting this is an autonomous domain.	1.1992e-22
NC_015690.1\|WP_013916029.1\|2458383_2458758_+\|VOC-family-protein	gnl\|CDD\|319909	cd07245, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	6.356e-28
NC_015690.1\|WP_013916031.1\|2459514_2460372_+\|phosphotransferase	gnl\|CDD\|366736	pfam01636, APH, Phosphotransferase enzyme family. This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.	1.71558e-05
NC_015690.1\|WP_013916028.1\|2457620_2458115_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|128898	smart00650, rADc, Ribosomal RNA adenine dimethylases.	1.18242e-11
NC_015690.1\|WP_013916018.1\|2449819_2450647_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	1.1677e-87
NC_015690.1\|WP_013916021.1\|2452939_2453086_+\|hypothetical-protein	gnl\|CDD\|226063	COG3533, COG3533, Uncharacterized protein conserved in bacteria [Function unknown].	8.68235e-05
NC_015690.1\|WP_013916011.1\|2444182_2444386_+\|cold-shock-protein	gnl\|CDD\|224197	COG1278, CspC, Cold shock proteins [Transcription].	1.01896e-33
NC_015690.1\|WP_013916013.1\|2444874_2445984_-\|GAI-protein	gnl\|CDD\|335361	pfam03514, GRAS, GRAS domain family. Proteins in the GRAS (GAI, RGA, SCR) family are known as major players in gibberellin (GA) signaling, which regulates various aspects of plant growth and development. Mutation of the SCARECROW (SCR) gene results in a radial pattern defect, loss of a ground tissue layer, in the root. The PAT1 protein is involved in phytochrome A signal transduction. A sequence, structure and evolutionary analysis showed that the GRAS family emerged in bacteria and belongs to the Rossmann-fold, AdoMET (SAM)-dependent methyltransferase superfamily. All bacterial, and a subset of plant GRAS proteins, are predicted to be active and function as small-molecule methylases. Several plant GRAS proteins lack one or more AdoMet (SAM)-binding residues while preserving their substrate-binding residues. Although GRAS proteins are implicated to function as transcriptional factors, the above analysis suggests that they instead might either modify or bind small molecules.	2.30433e-32
NC_015690.1\|WP_013916032.1\|2460396_2460897_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	2.48041e-12
NC_015690.1\|WP_013916012.1\|2444478_2444715_+\|cold-shock-protein	gnl\|CDD\|372943	pfam14169, YdjO, Cold-inducible protein YdjO. This family includes the B. subtilis YdjO protein, which is functionally uncharacterized. This is not a homolog of E. coli YdjO. B. subtilis YdjO is cold-inducible. Its expression is induced by the extracytoplasmic function sigma factor sigma-W. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.	1.67292e-29
NC_015690.1\|WP_014369765.1\|2456205_2456871_+\|hypothetical-protein	gnl\|CDD\|377924	pfam07833, Cu_amine_oxidN1, Copper amine oxidase N-terminal domain. Copper amine oxidases catalyze the oxidative deamination of primary amines to the corresponding aldehydes, while reducing molecular oxygen to hydrogen peroxide. These enzymes are dimers of identical subunits, each comprising four domains. The N-terminal domain, which is absent in some amine oxidases, consists of a five-stranded antiparallel beta sheet twisted around an alpha helix. The D1 domains from the two subunits comprise the 'stalk' of the mushroom-shaped dimer, and interact with each other but do not pack tightly against each other.	1.51965e-07

>NC_015690.1|WP_013916021.1|2452939_2453086_+|hypothetical-protein
MLPPVALYFVRSKSDDGRGAVLLPLQAVPYFAWSNRTPGEMTVWIRSS
>NC_015690.1|WP_187296742.1|2452732_2452888_+|hypothetical-protein
MDPQQLSGGKAVASGGAGVRADAVLPPLQAVPYSDRGNRTTGEVTVWIRSS
>NC_015690.1|WP_013916019.1|2450768_2452751_+|glycoside-hydrolase-family-127-protein
MSTIENRLGKTLTPVPLRQVTIQDPFWSARERNVIDTVIPYQWDALNDAIPGAEPSHTIENFRLAAGEAAGDYYGMVFQDSDLGKWLETVGFALSKERSPELEKIADDVIDLLERAQGPDGYLNTYYTVKEPGARWTNLRDNHELYCAGHLMEAAVAYYDATGKRKLLDIMCRYADYIGEVFGREPGQKRGYDGHPEVELALVKLYQASGNRAYLELSRYFVEERGQLPHFFDTEDQERAAAQGDGGAARKRKRGYDYFQAHLPVRDQKTAEGHSVRAVYLYSAMADLAMQYRDAGLREACRELWNDVVERKMYVTGGIGSSAYEERFTVPYDLPNDRAYTETCAAIGLMFWAQRMLQMEQDRRYADVMELALYNGVLSGISLDGKSYFYVNPLEVWPDTANFRDDMRTVKGTRQPWFGCACCPPNIARLIASLGQYIYSVNEEQRELHVHLYAGSRAEVVLGGQPVTLTQTTEYPWNGQAALEIGLAQPAEFTVCVRIPGWCRKAAVTVNGAGTDTGQLEKGYVRITRTWSDGDRIELSFDMPVEIVRAHPNVRAAAGRIALQRGPVVYCLEEADNGPNLQDIVVERDAEFEAEFDAGLLGGVTVLRGMGTRSVVPPEGAGVLYTTQEYDRTAVPLQAVPYFAWSNRTPGEMTVWIRSS
>NC_015690.1|WP_013916018.1|2449819_2450647_+|carbohydrate-ABC-transporter-permease
MKNHAALRAAAHLVLLAGAVTMILPFLWTVSTSLKQLSEVFVFPPKPFGAELQWGNYLRISERFPFDTYFFNSVKITLIVVAAQLVTSSMAGFVFARLRFRGRDLLFGLYLATMMVPAQVTMIPNFIVMRSYNLVDTHWALILPALVSAFGTFLLRQFFVTIPESLEDAAKIDGCTPFGIYWRIFIPLSKPAMATLGVFVFMGTWNDFIAPLVYINSVDLMTLPLGLASMQGMYSTDWPVLMAGTVICILPLIVIFLLAQDFFIKGVTLSGLKGE
>NC_015690.1|WP_013916017.1|2448855_2449815_+|sugar-ABC-transporter-permease
MNAEGRLGKSGAASLHTEKPGGAVSAVKRWFHKDGTWAILLLLPNIIGFLAFTLIPVIASFLLSFTSWDMLSPIRWVGFENYAALLKDETFIKVFWNTIYFAGVSVPVGIVCSLFLAVALDQGIAFKKFYRAAYFLPVVSSMVAVAVVWQFIYNPEYGLLNYALSLIGIKGPNWLTSTVWAMPAVILTSVWKNVGFNMLIFLAGLQGIADSYYEAAELDGARWHQKFWYVTVPLLSPTTFFVTVMSFIGSFQVFDTVFLMTQGGPARSTSVIVHYLYENAFKYFNMGYASAMAYVLFFIVFLITLFQLWRQKKWGAYGG
>NC_015690.1|WP_013916016.1|2447467_2448799_+|sugar-ABC-transporter-substrate-binding-protein
MRKLHTVSTVLLCSVFTAACSGGGSPAGDPGSAGDKGGGTAGGVVTLKFMGWEASPLETKSVKKGLEAFMAKHPNIKVEYQPVPNTQYSQKLLTMLAGGAAPDVFFLGSTDYRAFQKRDVLLDLTSMFKADMSLDDFIPSSAQIMDIGGKIYGVSSCTVSPVLYYNKAVFDKAKVPYPPSDPAKAWTWEEFLDAAKKLTVKEGDKVVQYGAFGLENFYMTSAQILSNGGQLFSSDVTKMAINTPEAQEVLQSIYDLRVKHGAAPTAKTLESIGMKANQMLQTGKVAMAVDGSWALQELATMGFPVGVAALPKFKEAVTHGQAHVHAAAAKTKHPKEAWELVKFLSSEEYQIDNIKEGLWMPNRKSLYTEEGVKKWYNASVHPEGFQSLVPYFKEARAFPFPLITQNKVNDIITEETDKLWYSGQSVADTLKNIESRSNVELAK
>NC_015690.1|WP_013916014.1|2446303_2447194_-|helix-turn-helix-transcriptional-regulator
MHYFKTGIERPVEFLSCGLFVSDVPWTHANRIVDSFEIIIGVSKRLYIAQGGTRYEVKPGEVLLLPPGQIHEGYRECEEGISFYWFHFLPAGPYELLDESALSEELAHLNDPDFCRTFSQVCFPLYYTNPRIERVNILFQQLQHIASSNYYTRSAAHYLSTSLLIELSEQMISDYYSSSRMTQGDKSISEIIEWIRIHMRENISVTDVADKFAYNKNYLSRFFKKKTGYNLQEYIHLLKISKAKDLLTRSTRSIKVIAEGVGFQDEKYFMRLFKKYENMTPTEYREAYYRLHMNNH
>NC_015690.1|WP_013916013.1|2444874_2445984_-|GAI-protein
MYSPYAAPSAADHFGQLQTFLARTLTPDAAARTQSELVRFAESLRIDEEASHMLPYLFAKALVKRLDPASHEQMNLYLKQYDVPQITLFNLLASKFPLMNDVTRLANAMLLQAIETGQHVRLLEIGIGTGRQIVGLLHQLKELGKSPASFTIHAIEPNLSCLQEAMDNVGKAAEGLDFPVIFHPIHAEIEQLTDADWQRLIPRQPGLLVNASFALHHIRGIRLGLENKDEVLRQIRLLNPSLVVLCEPDSDHHHPQIEQRMRNCWNHFSALFELIDSVQLPVEHSRGLKLFFGREIEDILSAPETLRCERHEATVNWIARLSEAGFQPCQALQPPEAGSLPDVGITSGAWHVGFGSRALNLISVLCAVS
>NC_015690.1|WP_013916012.1|2444478_2444715_+|cold-shock-protein
MYNKRIPIEDLPHAETKVWTCSDAGCKGWTRDNFTFEQAPTCHLCRSAMVSSIRMLPLIPNSNKEMKTRNQGVLINEG
>NC_015690.1|WP_013916011.1|2444182_2444386_+|cold-shock-protein
METGTVKWFNAEKGFGFIEREGGNDVFVHFSAIQGEGFKSLDEGQRVEFNVVQGNRGPQAENVVKVY
>NC_015690.1|WP_013916022.1|2453909_2454560_-|hypothetical-protein
MRISNSTAAAAEFVSCRLKAGVDRVDFLRHVHASQASLKQYPGYVSRELYHDVHQDTWFDLVRWSDLQAAEHAAETFMDDPHAAGLIGCLDPAGLAMHHYNWREELGAVSARNPIDTPSGCVELLQYRLLAGACLPNYEDVLREMSETLRTHAGFIRREVYYIAKTGQWLETIFYRDRASADAMFAEIKDAPCMKACMELLDETTLTMTFAVPVEF
>NC_015690.1|WP_041616793.1|2454692_2455637_+|YafY-family-transcriptional-regulator
MHKAQRLVQLIMLVNERMRFTVQELADECGVSRRTMIRDLMELGELGVPLYSEVGAGGGYRVLREKVLPPISFTEQEAMALFFAAQSLRNYRSLPFGNEVEGALHKFFHYLSSDLKAKIIRMQQRLVFWVPPHELEAPHLGELFEAALEQRVVTLLYESSSLRERNIQPLGIYTMNGLWYCQAYCFSTGEYRVFRVDRVQSCQPAKDQSVRLDAGGEPIDKWIMRPAENADLVLEVELTPEGARRCRTDVWLAKTLRVHDDGSGSIRTPMPDSYVPWAVHFFLGLGVEANVKGPKQVREGIHGKLREMLVQYEE
>NC_015690.1|WP_013916024.1|2455650_2455968_+|TfoX/Sxy-family-protein
MAQERKREAGGGRIKNMGPKGSQWLESIGIKTREDLERVGSVEAYKRLKESIPGVSILALYAMEAALWDLHWNALPEEIKASLQEQVGHTPPNRAARKGTGTGID
>NC_015690.1|WP_014369765.1|2456205_2456871_+|hypothetical-protein
MKKITAAAVLAVTALGSAAVGVYAASDLKLFVNGKPSPSVVENINGSSYVPLRAVAEMLGAEVKWNGDSRTIHIDAKDAHPEEASVPAAPAEAKTFATSIAVSSGPMRMQISKVILDPAYKKEGAPAPMKAVVLEVKVENTSDERLTWQVGNGKVITNTQEQINGSAASDPVGGEFNGKVIKTGKIVFEVENLDGITSLQYFAEGAYKEGYNPAGANITWK
>NC_015690.1|WP_014650547.1|2456981_2457425_-|ribonuclease
MKTALRFIAMFALMLSLVFGSVGSVIPNGGTPTAEAAVSGPTDFAGIINYIKANGWLPSNFITKSQATQRGWVSSQCNLATVAPGYSIGGDVFYNREGKLPSASGRVWYEADAYYTSGCRGAQRVLFSNDGLYYTTSDHYATFKRWY
>NC_015690.1|WP_013916028.1|2457620_2458115_+|methyltransferase-domain-containing-protein
MESKHTFNEVTREYERYRPRYPKELFEEIAASNSVTPTSPILDIGCGTGQATGGLVESGFDRITCIELGEKLAAAVREKFRHSPNVQVVHAHSKSGRRAPRGTIWRCRPRPFTSNSLRSSVTGWCMICFTRVEASGGCGSTHELTEDEKAAGEAVQAAGYRITA
>NC_015690.1|WP_013916029.1|2458383_2458758_+|VOC-family-protein
MPFSFEGIDHIQLAAPEGCEEEARGFYAELLGWQEIPKPEPLKKRGGVWFQCGTHQVHIGVQQDFRPALKAHPAFAVRGLEELRARLVQIGIHVIDDEIRAEEGISRIYVRDPFGNRLEFLERH
>NC_015690.1|WP_013916030.1|2458784_2459480_+|LysE-family-transporter
MSILLLSKGILIGLAIAAPVGPIGLLCIRRSLVHGRIYGLVSGLGAATADTIYGFIAGFGLTAVSGFLTAHAFWLQLLGGIFMCYLGWRTLRSKPPEQSAAVQGGSLLKSYSSIFLLTITNPMTILSFAGIFAGLGLTAGSSDWTASLFLVGGVFVGSALWWLLLSTGVGLLRHRLSPSSLAWINRISGWIIMGFGFAAVSLAVHSAVLRLQRDSWLILILSIAWAGSVIL
>NC_015690.1|WP_013916031.1|2459514_2460372_+|phosphotransferase
MAQRADVQDLLQTLRRTGVVDRRTYTQEQLKGTTDGVVYELAVAGETAYILKLDCPEQIRQVERFYEAYADSSLLPRLLQADPAGGSMVYSYVPGTTHIHRGPKVRWMIRLVQELLNQYQAYPGIGGWGRLEAPRESWRAFQERSAEDASRILAGVLPAEDHARIRGLIGRISDAGEPYLLHGDTGIHNFVFHHRELSGVIDPSPMTGPVLYDFTYAFCSSPDDLNLDTLLAAYDMLDPKPVDRTRLMEETFFQLYCRIAICVRVHPQDLEGYLQVWPYWRDLIS
>NC_015690.1|WP_013916032.1|2460396_2460897_+|GNAT-family-N-acetyltransferase
MEPAKEFEITVRRPTVAEHQMLWQAAGWGTVDSRMAEASLARSVHAVVAEAEGRVVGMGRIVGDGVMYFYIQDVAVLPGYRERGVGRAIMERLLAYIRANRYEQGLAFVGLFASPGKEGFYERFGFRDHSPGMTGMFLVMEDAAPAREDRETGGSGEENSEGRESP

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Crispr_ID: NC_015690_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015690_13

2523591-2524110

Orphan

Consensus_repeat	Method
NCGGAAAATCCGTNTTCG	CRT
CCGAACGCAGCCTCTGTAAGACGGAAAATCCGTCTTCGAGCGGCCAATCCGCC	PILER-CR

9 spacers

The CRISPR arrays of NC_015690_13

>merge|NC_015690|13|2523591-2524110|CRT,PILER-CR
CCGGATTTTCCGTGTACGGTCGACCAATCCGCCCTCGGCAGGCCGGCGAACGCGGAAAATCCGTGTTCGGAGCCGGAAGCCTCGGACATTCGGCCGAACGCAGCCTCTGTAAGACGGAAAATCCGTCTTCGAGCGGCCAATCCGCCCTCGGCAGGCCGGCGAACGCGGAAAATCCGTGTTCGGAGCCGGAAGCCTCGGACATTCGGCCGAACGCAGCCTCTGTAAGACGGAAAATCCGTCTTCGAGCGGCCAATCCGCCCCCAGCAAGCTGGCTAACACGGAAAATCCGTCTTTGGAGCCAGAATCCTTCGGGAATCGGCCGAACGCAGCCTCTGTAAGACGGAAAATCCGTCTTCGAGCGGCCAATCCGCCCTCGGCAGGCCGGCGAACACGGAAAATCCGTGTTCGGAGCCGGAAGCCTCGGACATTCGGCCGAACGCAGCCTCTGTAAGACGGAAAATCCATCTTCGAGCGGCCAATCCGCCCTCGGCAGGCCGGCGAACACGGAAATCCGTGTCCG

>NC_015690|13|1|2523591-2524110|CRT
CCGGATTTTCCGTGTACG	GTCGACCAATCCGCCCTCGGCAGGCCGGCGAAC
GCGGAAAATCCGTGTTCG	GAGCCGGAAGCCTCGGACATTCGGCCGAACGCAGCCTCTGTAAG
ACGGAAAATCCGTCTTCG	AGCGGCCAATCCGCCCTCGGCAGGCCGGCGAAC
GCGGAAAATCCGTGTTCG	GAGCCGGAAGCCTCGGACATTCGGCCGAACGCAGCCTCTGTAAG
ACGGAAAATCCGTCTTCG	AGCGGCCAATCCGCCCCCAGCAAGCTGGCTAAC
ACGGAAAATCCGTCTTTG	GAGCCAGAATCCTTCGGGAATCGGCCGAACGCAGCCTCTGTAAG
ACGGAAAATCCGTCTTCG	AGCGGCCAATCCGCCCTCGGCAGGCCGGCGAAC
ACGGAAAATCCGTGTTCG	GAGCCGGAAGCCTCGGACATTCGGCCGAACGCAGCCTCTGTAAG
ACGGAAAATCCATCTTCG	AGCGGCCAATCCGCCCTCGGCAGGCCGGCGAA
CACGGAAATCCGTGTCCG

>NC_015690|13|4|2523797-2523962|PILER-CR
CCGAACGCAGCCTCTGTAAGACGGAAAATCCGTCTTCGAGCGGCCAATCCGCC	CCCAGCAAGCTGGC
TAACACGGAAAATCCGTCTTTGGAGCCAGAATCCTTCGGGAATCGGCCGAACG	CAGCCTCTGTAAGACGGAAAATCCGT
CTTCGAGCGGCCAATCCGCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015690.1\|WP_013916108.1\|2534188_2535220_+\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|307170
NC_015690.1\|WP_041616806.1\|2520061_2522122_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227511
NC_015690.1\|WP_013916110.1\|2535660_2536074_-\|DUF2203-domain-containing-protein	unknown	unknown	gnl\|CDD\|378330
NC_015690.1\|WP_013916096.1\|2518447_2519668_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|350126
NC_015690.1\|WP_013916105.1\|2528862_2529600_+\|ribonuclease-Z	unknown	unknown	gnl\|CDD\|293830
NC_015690.1\|WP_013916093.1\|2517184_2517433_+\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013916087.1\|2511892_2513860_-\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013916099.1\|2522643_2523495_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NC_015690.1\|WP_187296743.1\|2526099_2526246_+\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013916103.1\|2526240_2527002_-\|response-regulator	unknown	unknown	gnl\|CDD\|333815
NC_015690.1\|WP_014650585.1\|2535303_2535459_+\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013916088.1\|2513991_2514441_+\|acetyltransferase	unknown	unknown	gnl\|CDD\|182510
NC_015690.1\|WP_013916086.1\|2510920_2511769_+\|bifunctional-5,10-methylene-tetrahydrofolate-dehydrogenase/5,10-methylene-tetrahydrofolate-cyclohydrolase	unknown	unknown	gnl\|CDD\|184561
NC_015690.1\|WP_013916104.1\|2527041_2528787_-\|GHKL-domain-containing-protein	unknown	unknown	gnl\|CDD\|225827
NC_015690.1\|WP_013916101.1\|2524483_2525641_+\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NC_015690.1\|WP_013916107.1\|2532679_2534053_-\|PLP-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|224089
NC_015690.1\|WP_013916094.1\|2517422_2518274_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187627
NC_015690.1\|WP_013916092.1\|2516890_2517181_+\|fatty-acid-CoA-ligase	unknown	unknown	gnl\|CDD\|341284
NC_015690.1\|WP_013916090.1\|2514627_2516418_-\|oligoendopeptidase-F	unknown	unknown	gnl\|CDD\|341071
NC_015690.1\|WP_013916106.1\|2529837_2532432_+\|glycoside-hydrolase-family-2-protein	unknown	unknown	gnl\|CDD\|225789

Protein	Function_ID	Function_description	E-value
NC_015690.1\|WP_041616806.1\|2520061_2522122_+\|hypothetical-protein	gnl\|CDD\|227511	COG5184, ATS1, Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton].	2.70258e-49
NC_015690.1\|WP_013916110.1\|2535660_2536074_-\|DUF2203-domain-containing-protein	gnl\|CDD\|378330	pfam09969, DUF2203, Uncharacterized conserved protein (DUF2203). This domain, found in various hypothetical bacterial proteins, has no known function.	1.10111e-44
NC_015690.1\|WP_013916096.1\|2518447_2519668_+\|hypothetical-protein	gnl\|CDD\|350126	cd18614, GH130, Glycosyl hydrolase family 130; uncharacterized. This subfamily contains glycosyl hydrolase family 130 (GH130) proteins, as classified by the carbohydrate-active enzymes database (CAZY), most of which are as yet uncharacterized. GH130 enzymes are phosphorylases and hydrolases for beta-mannosides, and include beta-1,4-mannosylglucose phosphorylase (EC 2.4.1.281), beta-1,4-mannooligosaccharide phosphorylase (EC 2.4.1.319), beta-1,4-mannosyl-N-acetyl-glucosamine phosphorylase (EC 2.4.1.320), beta-1,2-mannobiose phosphorylase (EC 2.4.1.-), beta-1,2-oligomannan phosphorylase (EC 2.4.1.-) and beta-1,2-mannosidase (EC 3.2.1.-). They possess 5-bladed beta-propeller domains similar to families 32, 43, 62, 68, 117 (GH32, GH43, GH62, GH68, GH117). GH130 enzymes are involved in the bacterial utilization of mannans or N-linked glycans. Beta-1,4-mannosylglucose phosphorylase is involved in degradation of beta-1,4-D-mannosyl-N-acetyl-D-glucosamine linkages in the core of N-glycans; it produces alpha-mannose 1-phosphate and glucose from 4-O-beta-D-mannosyl-D-glucose and inorganic phosphate, using a critical catalytic Asp as a proton donor.	1.53815e-29
NC_015690.1\|WP_013916105.1\|2528862_2529600_+\|ribonuclease-Z	gnl\|CDD\|293830	cd16272, RNaseZ_MBL-fold, Ribonuclease Z; MBL-fold metallo-hydrolase domain. The tRNA maturase RNase Z (also known as tRNase Z or 3' tRNase) catalyzes the endonucleolytic removal of the 3' extension of the majority of tRNA precursors. Two forms of RNase Z exist in eukaryotes, one long (ELAC2) and one short form (ELAC1), the former may have resulted from a duplication of the shorter enzyme. Only the short form exists in bacteria. It includes the C-terminus of human ELAC2 and Escherichia coli zinc phosphodiesterase (ZiPD, also known as ecoZ, tRNase Z, or RNase BN) is a 3' tRNA-processing endonuclease, encoded by the elaC gene. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	3.34217e-18
NC_015690.1\|WP_013916108.1\|2534188_2535220_+\|DMT-family-transporter	gnl\|CDD\|307170	pfam00892, EamA, EamA-like transporter family. This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.	3.97454e-17
NC_015690.1\|WP_013916099.1\|2522643_2523495_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	2.30539e-26
NC_015690.1\|WP_013916103.1\|2526240_2527002_-\|response-regulator	gnl\|CDD\|333815	pfam00072, Response_reg, Response regulator receiver domain. This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.	8.8916e-22
NC_015690.1\|WP_013916088.1\|2513991_2514441_+\|acetyltransferase	gnl\|CDD\|182510	PRK10514, PRK10514, putative acetyltransferase; Provisional.	1.33532e-43
NC_015690.1\|WP_013916086.1\|2510920_2511769_+\|bifunctional-5,10-methylene-tetrahydrofolate-dehydrogenase/5,10-methylene-tetrahydrofolate-cyclohydrolase	gnl\|CDD\|184561	PRK14192, PRK14192, bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD.	6.06265e-132
NC_015690.1\|WP_013916104.1\|2527041_2528787_-\|GHKL-domain-containing-protein	gnl\|CDD\|225827	COG3290, CitA, Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms].	1.71149e-23
NC_015690.1\|WP_013916101.1\|2524483_2525641_+\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	1.12148e-74
NC_015690.1\|WP_013916107.1\|2532679_2534053_-\|PLP-dependent-aminotransferase-family-protein	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	5.0964e-117
NC_015690.1\|WP_013916094.1\|2517422_2518274_+\|SDR-family-oxidoreductase	gnl\|CDD\|187627	cd05369, TER_DECR_SDR_a, Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR. TTER is a peroxisomal protein with a proposed role in fatty acid elongation. Fatty acid synthesis is known to occur in the both endoplasmic reticulum and mitochondria; peroxisomal TER has been proposed as an additional fatty acid elongation system, it reduces the double bond at C-2 as the last step of elongation. This system resembles the mitochondrial system in that acetyl-CoA is used as a carbon donor. TER may also function in phytol metabolism, reducting phytenoyl-CoA to phytanoyl-CoA in peroxisomes. DECR processes double bonds in fatty acids to increase their utility in fatty acid metabolism; it reduces 2,4-dienoyl-CoA to an enoyl-CoA. DECR is active in mitochondria and peroxisomes. This subgroup has the Gly-rich NAD-binding motif of the classical SDR family, but does not display strong identity to the canonical active site tetrad, and lacks the characteristic Tyr at the usual position. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	1.0063e-120
NC_015690.1\|WP_013916092.1\|2516890_2517181_+\|fatty-acid-CoA-ligase	gnl\|CDD\|341284	cd12119, ttLC_FACS_AlkK_like, Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles. This family includes fatty acyl-CoA synthetases that can activate medium-chain to long-chain fatty acids. They catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family catalyzes the long-chain fatty acid, myristoyl acid, while another member in this family, the AlkK protein identified from Pseudomonas oleovorans, targets medium chain fatty acids. This family also includes uncharacterized FACS proteins.	1.04237e-31
NC_015690.1\|WP_013916090.1\|2514627_2516418_-\|oligoendopeptidase-F	gnl\|CDD\|341071	cd09608, M3B_PepF, Peptidase family M3B, oligopeptidase F (PepF). Peptidase family M3B oligopeptidase F (PepF; Pz-peptidase B; EC 3.4.24.-) is mostly bacterial and includes oligoendopeptidase F from Lactococcus lactis. This enzyme hydrolyzes peptides containing between 7 and 17 amino acids with fairly broad specificity. The PepF gene is duplicated in L. lactis on the plasmid that bears it, while a shortened second copy is found in Bacillus subtilis. Most bacterial PepFs are cytoplasmic endopeptidases; however, the Bacillus amyloliquefaciens PepF oligopeptidase is a secreted protein and may facilitate the process of sporulation. Specifically, the yjbG gene encoding the homolog of the PepF1 and PepF2 oligoendopeptidases of Lactococcus lactis has been identified in Bacillus subtilis as an inhibitor of sporulation initiation when over-expressed from a multicopy plasmid. This PepF family includes Streptococcus agalactiae PepB, a group B streptococcal oligopeptidase which has been shown to degrade a variety of bioactive peptides as well as the synthetic collagen-like substrate N-(3-[2-furyl]acryloyl)-Leu-Gly- Pro-Ala in vitro.	0
NC_015690.1\|WP_013916106.1\|2529837_2532432_+\|glycoside-hydrolase-family-2-protein	gnl\|CDD\|225789	COG3250, LacZ, Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism].	2.2684e-111

>NC_015690.1|WP_013916099.1|2522643_2523495_-|AraC-family-transcriptional-regulator
MMIPPMAEPYLFDYRRTSLHDFKEVFHAHPEMEFTYVHEGEGNLILEGRTYAISPGTLLMFHPFQLHRIRMDVAPGRPFVRTLLIFDPAVLQPYWSQFPALKEFFQSLKLSQPVSPPLSLAPGDPAVSLLTQFHDTLPQLAPHETQEEYAFLLLSFLRQLRRFRQPAAGPSAPASRCSHRAEEIMQWIERHYADPFELERLARELHISRYHAAHLFKEATGTTILSYVHATRVRHACVLLRQTLLAIPEIGIRTGYPNPSYFCRVFREAMGTTPHQYRLRVQK
>NC_015690.1|WP_041616806.1|2520061_2522122_+|hypothetical-protein
MFWVCGFLLMSLLLPFQAAAAEVGSAVAAESSKSGVTMVAAGRFHSLALKEDGTVWAWGKDSLGNGTPYSSATPVQVKDLEEVVTVAAGGNHSLALKSDGTVWAWGQNEYGVLGEDPYKTSWRLTPVQVQGLSSVVAISANFSHNLALKSDGTVWAWGMNNAGQLGNGTTSDMYTSFYTPSQVQGLDSVIAVAAGPGTSLALKSDGTLWAWGGLVGDGTTESRSTPVQAQGLSSVVSFDAGDSRFVVKSDGTVWAWGWNGYGQLGDGTTTTRYTPVPLQELSSVAAFAADEWHSLALKSDGTVWEWGCNSKGEMCYESDIRTTPVQVQDLSSAVDIAAGFEHSLAVKSDGTVWAWGNNGYGQMGDAARTYHSTPIQVLGLGEPSPNTPEAPQWPAGNILSVTEATYNSVILNWVQAVDDTGIAGYRLYQDDLFLGNVTGTTYKVTGLKASTSYLFHLTAFDKSGNVSLPSPSLSVTTDTYTPQPEKAPLALNVKSGFYEVGSEVEVYVHAKDQQDLYAFLLKIGYDPAKLRLNQILLSKEFGVEGQSAVFSKNTSKAGLAGVSGSLLGSTTGRNGDVKSAVLKFTLLAKGSSEIVLNPGSSTADSKNQIRQLTEPVKLVISTSSIDFNGDGLVGLEDLVLISRKSGEVSGQTAGFDARYDINHDGVINVPDVQYVANKVASVAIVN
>NC_015690.1|WP_013916096.1|2518447_2519668_+|hypothetical-protein
MKPQFSYSPEPVLVPQPGCDWASKMVLNPAIVQDPEEADTLHMLFRATGPWPQKQREGKYPPYPIFLGYAVSHDRGQTWDADFSRPALAPELGWEEEELKVTDAVGRQVWNYANGCIEDPRIFPVEGQLYLSAACRLFPPGPYWLVDGDPPIETRYDYVPEWTQEGEGPFYETCRTNVTVTVLYRLDLDKLKARRYEEAFAYVGPLTEGHVSDNRDVFLFPERMKIHGRLQYVMLHRPMTPAAFPDGADLGPSIYLAAAEEIGDFASPKAEHRLLAAGRFDWEENRIGASWPPLRISEDEWLVAYHGKKDAHFGYTQSFLIVLEQEDDFPVVTHRCSERMMYAQQEWEMPTDYPTPCLFTTAGILVGDDLVMAYGAADQKVGLSWVNWAELVAYVRLFDADGVKKG
>NC_015690.1|WP_013916094.1|2517422_2518274_+|SDR-family-oxidoreductase
MFDKELLRDKVVLITGGGTGLGRAMGERFLELGAKLAITSRREEVLALTASELRAAGGEVFHTPCDVRDAAQVQMMIDAVEGHYGHIDVLVNNAAGNFASPTESLSPRAVDAVLNIVLHGTFYTTLELGRRWIAAGRGGTMLNIVTTYASTGSAFVVPSAAAKAGVLALTRSLAVEWARYGIRQAAIAPGLFPTDGAWSRLAPTPELAEKLVQGVPLKRVGEKAELANLAAYLISDYAGYINGEVVTIDGGEWLQGAGQFNDLLEVTPEEWSELAGLTRKGKS
>NC_015690.1|WP_013916093.1|2517184_2517433_+|hypothetical-protein
MNHTLIGLNLRMNAVQGRLKQVEPAVLTADEHERSSEAEAAAAEHPAKWLVRGLFGGYRRLREKGSAVPGSRQAGRGRRHVR
>NC_015690.1|WP_013916092.1|2516890_2517181_+|fatty-acid-CoA-ligase
MTVSRLAHPAVFEACVIGVPHVKWDERPLAFVSWKEGAEGTAGKEELAFLGERFVKWWIPDDVVVLKEIPRTSVGKFMKRELRGQYKDHYQSGDGA
>NC_015690.1|WP_013916090.1|2514627_2516418_-|oligoendopeptidase-F
MPNQLQRQDVPAHEKWNLADIYPSPAAWDEDYAKIETLITTVKAFENQLTASGSLLAFLRSQEEMYRLYEKVYVYASLQLAQDTRETSSQALLDKASQLGVRVSASTAFFSPFLMSLDPEVLEGYIKEEEGLRYYERDLYEEYKYKKHVLSQEKEEVLSQLGEVIGAPRTIFNMLNNADIRFGKVHNEEGGEVPLTRGMYAKIMEHQDRSKREEAFHAFNKPYLELKNTIAATLGSSVKNNVLFSRMRGYESPLQRSLFKDDVPVSVYDNLLEATKANLAPLHHYLQVRKKALGVEDLRVYDLSVPLVTDVEMTIPYEEAYDTMLAALAPLGDEYVSVLAGARTSGWIDVRETEGKRSGAFCSGPYGTHPYVLLNHNNTFDSMFTLAHEMGHAMHSYYSDKHQPAISAQYTIFVAEVASTVNEVLLMKHYLKQNPSASLKKYLLNHFIDEFRGTYFTQVMFAEFEKRVHEKAMRGETLNSDSLSEVYEDLYKTYYGDVLELNPEVKYGWARIPHFYNAFYVYKYATGYASAFHLASRIFDGDSDTVRTYLEFLKSGRSEYPLELLRRTGVDLLQPEPIQGAMEAFAGIVKEFESTF
>NC_015690.1|WP_013916088.1|2513991_2514441_+|acetyltransferase
MTIDIIAYQEKFHDQLVDIWYRAVRQTHTFLTEEDMEFYHGIVRGGALREAEIWIALRDHREPVGFIGLDGSKIEMLFIDPSYHGQGIGSGLIRHVESMHGGSLQVDVNEQNDGACAFYKRYGFVQSGRSELDGAGRPFPLLHMELRRI
>NC_015690.1|WP_013916087.1|2511892_2513860_-|hypothetical-protein
MWKKPTLAVLLGISLTLLATAPGSASEYADTPTLPADGDHIPKTVTLLKETPYYAIPNVLLNQPEGAFSPQTVEIVEAEAHWAAFPNWWKIRTVFGDRWIKTEPGTFEVPLPSKLTLLQETPIYAKADERLKPSAVLSPQEVTVAGAEKRWFYSALNDENEQKWIQIETSWLGRQWIRLPMKQIGSLKRHSQIKFYGLTQLSTLPPMLETPGTSVPAYEGRNRILTETVEFITPLGSFYEVETTEGRRWTRTPGQVITASQETLTRSKPAALYPLPSLDSGEPVLVDPQILKVSEKIEGDPVNDYDGGWYHVKAAEGEGWFNARFSEPEDAKPVTAEVDLRADMTPLYLYPDSSLLLHNGILSPQKVQATAYWDAPKGERWFRIQTFLGDAWMVLNPLHDRIRPAGREQDQQIYGEKRYQGYYYMNNGVLPYGEEKAGYERQNELYFRSSFLAKMYHFSVSGPDADNGWTFTHESGYAFRLKAGEKKAELFWKGRNAGTALLSAVPAVSVDKEAPDLRLDSMRALFGASTETAPDHSWVSLSSSEYTLGDFKPPVRIEGNVLRLSALLYDVERPETNETPNRLKLYVIDRDADRSMAFTAQNPAAQDKLFSMNMNMALYDLTAQKTLKPGLNRLTAVFKVGERIIHEQDFDVTAQ
>NC_015690.1|WP_013916086.1|2510920_2511769_+|bifunctional-5,10-methylene-tetrahydrofolate-dehydrogenase/5,10-methylene-tetrahydrofolate-cyclohydrolase
MREPIVLDGSRVAAEIKANLAGRVERLKELGIVPCLATILVGGDPASATYVKMKANACRRLGIESVRVELPETTTTEELLEAIGRLNEDPAVHGILLQHPVPGPIDERAAFDAIAIGKDVDGVTMLGFALNTFGAAAYPSCTPAAILTILDHYGIGIEGRHAVVVGRSPILGKPVSAMLLNRNATVTICHSKTTDLAEMVALGDIVVAAVGKPRFIQGEWIKPGAVVLDAGYNPGNVGDVDYEAACRNASAITPVPAGVGPVTISMLLKHTVEAAERAAGLR
>NC_015690.1|WP_013916101.1|2524483_2525641_+|Gfo/Idh/MocA-family-oxidoreductase
MLKIAIIGTGAISRAHIEAYLQFPDRCRIVAVSDIYQDKAEARIAEFGLEGARAVADYQELLQEDIDLVSVCTPPYTHAPISIDFLRAGKHVLVEKPMASSLQECDEMNAAARESGRILSVVAQNRFTAPLWKLKSVLDSGLMGPVVHAQVDSFWWRGHCYYDLWWRGTWEKEGGGCTLNHAVHHIDAFLWMMGRPAELQAFMSNTSHDNAEVEDLSIAMLRFPDGALAQITSSVVHHGEEQQLIFQGKRARVSAPWKVKASRSRPNGFPAADEELEAQIRELYDSLPGPEYAGHAGQVDNVLAAIETGAPVLVDGISGRSTLELILGIYKSASTGEKVTFPLQPDDPFYTREGIQANATHFYEKSASVENFQDLRIPTGAGESQ
>NC_015690.1|WP_187296743.1|2526099_2526246_+|hypothetical-protein
MNEAYVSRKLPVPPVRGMRPGHRLLPMPIPPDSSKPLPAGKVRMRWSS
>NC_015690.1|WP_013916103.1|2526240_2527002_-|response-regulator
MTYTVIIAEDDPLQARLLEQFCTEEGLQVFGAVSSGRRLIEEVTAGRPDLVIADITLKRQDGISAIREMIGDGLSPVVILVSGSVDPEHLLAGYDIAAVDYVRKPILRARFKQAVDRAKARVDARRRAAALPDQVNFITCKVRYRDLQFAEPQLLYAERTMLRKTKVVLSDGTHFLTSTPLHDIQAQCSERIVFSHRSYLVNTARIAAIETVPGGSRRNYEITLIGCPVKVPLTPTYYGECRQQMESFTGGPL
>NC_015690.1|WP_013916104.1|2527041_2528787_-|GHKL-domain-containing-protein
MLRRLFPSRPERRRWKPSLSMLLISLIIVLLTNSVFYYYTKNRMTRELEERLQLISDVLAVSIEHARAGEKHVEDLIGLNLRSVSIAAQSQLPADIEQVSNEELQTLSRQLMVDHITLMKRQGDDIVGYRSSDPKEIGMSTKDWRGDWFKAFNQLLDRKETQVPSGQALPNYWSGPINTSMTNPSSVDKWGYYHDGSTNYITDPFVHDTHLRSYQRDTGVDAFIREMTREDRLNAASEITVYNPPTFLKEQEQYRKDAFTWFSDREILFGSYTLKDSRDASSVREVMRTGQKQEFTTVLDGHTYLKMFIPLGLEYPAVIGLTADYEPILDWVREQQTQLTLLIGSTIFIGLLTLFLSARVMSRSRERTAESVQEVYTDKIDDLFRSMKEQQHDFNNHVAALSALVQLKQYEELTRYTEQLTEETHALNDIIQINVPALCAIVQAKLIESAQRKIRFTHDVENLSGANLGALKATDLVKVVSNLLDNAFDAVSASPRSDKHVGLTGRLADGRLQFVVANNGEPIPVAVRERLFEAGFTTKTESGDHEGLGLSIVQSILSRYKGQIEVHSSEAETRFVLSIPV
>NC_015690.1|WP_013916105.1|2528862_2529600_+|ribonuclease-Z
MKLTFLGAGDGFSVGQGHNSALLKFGGTNLCIDFPESNHAALHKLGLELNRVENVFVTHLHEDHINGLQKLAFYHGVYPLKGKPRLYVHEELLGDLWDALRHGLAYSTRGPKELSDFFEVVPVQEAFEIEGQRFELVRTVHIPGMISFGLLCAPYFYFSGDTRFDLGQIEEAASKAKVLFYECHMQPYNLPSHTSLDELLTLPEELQRRTVLMHYIDDYLDAEKREAFHNAHALRLAELLQAYEF
>NC_015690.1|WP_013916106.1|2529837_2532432_+|glycoside-hydrolase-family-2-protein
MTITKPAYMTLSGWEFKACKDEQWLPAAVPGCVHTDLLRNGKIEDPFYGTNEKRLQWIDKEDWEYRTSFAASSEQLSQANVELVFDGLDTYADVTLNGQPILSADNMFRSWRADVKELLQEENTLRIRFRSPIQEDLPKLRALGYALPAANDQSEAGGLGDEKVSVFARKAPYHYGWDWGPRFVTSGIWKDVRLESWSGIRIRDFHIRQDQVTAEAARLTALVEVESDEAWSGELRVSAEGRQWSRDVRLEAGSHTVELAAELESPRLWWSRGLGAQELTDFRAELVSGGDVHAQETVTTGLRSAKLVREKDAHGTSFYIELNGVPVFCKGANHIPNDSFVTEVTYERYRHEVASAAEANMNMLRVWGGGIYEHDDFYRLCDEYGILVWQDFMFACSMYPGDEAFLASVRAEAEENVKRLRRHPSVVLWCGNNEMDTAWSHYDENAGWGWKKKYSPELREKIWRDYEAIFHEILPQTIRALSPETDYWPSSPMREVTGDANQHATSSSPDGDIHYWGVWHNVEPFSNYKVHIGRFMSEYGFQSFPEEKTVETYAAEEDMALVSEVMLSHQKNGRGNMLIKEYMDQYLSEPKDFRSFLYMSQVLQGEAMKTAIEAHRRRMGFTMGSLYWQMNDCWPVASWAGMDYLGRWKALQYYAKRSFRDVMLSLDENDGKVEIHGVSDLQVPLTGTLELRLLDFQGNVLRQWSASVTLAANAAGHLKSLAREEVLEGADPASVVLTARFEGSEGATDLKEHYFVPVKDLRLEEPGVRVTRRTEGEQVLITLEADRLAKQVWLSSEAEGHFSDNFFDLLPGSPVTVAFRKRSDGGEPFAAGDPGSVQVRSMYDFIKSSAGAQEADRQAEEQAL
>NC_015690.1|WP_013916107.1|2532679_2534053_-|PLP-dependent-aminotransferase-family-protein
MLKYMELANEIEELIETLPLREGGKLPSIRTLAQRYECSKSTIIRTLQELERQHRIYAVPKSGYYVVRSRAASEDARTGVLDFIAAAPDPELFPYLDFQHCINKAIETYKNDLFVYGTPQGLPSLLRVVRSLLASSQIFTETDRLFVTSGVQQALSLLAAMPFPGGRRTVLIEQPGYHLMVRYLQTYGVPARGIRRTAEGIDMEELERLFRGGEIKFFYTMPRFHNPLGCSYTEDQKKQIVRLAAKHDVYLVEDDYMADFEENRRADPLFAHDPSGRVIYLKSFAKILFPGLRLGIAVLPRALAEVFSRHKKLQDIDTSMLSQAALEIYLKSGMFGRHKQRLSRSYAKKARLLQDSLQRAAGQLGDRAAFRPAPTPMIHTHLELHPGIDVPRLAARLARRSVLIGPMDQHYLEGFPRDPLLKLNVSQVKADEIERGVELIAEEISGSPLHTAKGLST
>NC_015690.1|WP_013916108.1|2534188_2535220_+|DMT-family-transporter
MLHMENKGRTREEGARKADGTRLQNNNEASRDRGQTAAYLAAVGNAVIIGFSFLFVKIALDTAHPLDTLAHRFTASFAVLALAAAFGWIRVKLRPREMAALLPLALLYPSLFFAFQAFGLAYSSSSEAGIIHATVPIFTALLAAAVLKEYAGVRQILFILLSAAGVVYIFVMKGAAIGSGALLGTVLILVSAGCMAAYSVLARRMTRRFTVMEMTFAMTLIGFVFFNGMSVIRHLLAGTLPAYFEPLGSLPFLGSVLYLGILSSMVTAMLNNYALSKLEASKAGVFTHLSTLVTMAAGALLLGEQLFYYHFVGAALIVLGVVGTNLPGSRKKPVSSAGRSMIR
>NC_015690.1|WP_014650585.1|2535303_2535459_+|hypothetical-protein
MANQRNQVSKADVQSTELNKLPVEGENDTEFSAEEAAEVFSENQNANNNQQ
>NC_015690.1|WP_013916110.1|2535660_2536074_-|DUF2203-domain-containing-protein
MNNRRFTLEEANAMLPRLREDLAKLQELVKQFEGLYQELKQAKAEYLLQPAGQEGGDPFFEMEGRLDFLRMEAELFIENFTRQGVLLKMIKPGLIDFPAVVDGEEVLICWKEGEERITHYHGWHDGFAGRKPFPGAY

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Crispr_ID: NC_015690_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015690_14

2686602-2686817

Orphan

Consensus_repeat	Method
AATCTGTTGGCTAGTACAACCT	CRT

4 spacers

The CRISPR arrays of NC_015690_14

>merge|NC_015690|14|2686602-2686817|CRT
CATCTGTTGGCTAGTACAACCTGTGCCGTTTCAATCCTTCCCTTTAATCTGTTGGCTAGTACAACCGCTTTCGGGGAGGACGCTCGCTGCGAATCTGTTGGCTAGTACAACCTTTATTGGATGTATTCTCTCCGTGCGAATCTGTCCGCCAGTACAACCTGGTTGTCCCTGGATGCCGCTGGAAAAAAAGCCCGAATCTGTTGGCTAGTACAACCT

>NC_015690|14|2|2686602-2686817|CRT
CATCTGTTGGCTAGTACAACCT	GTGCCGTTTCAATCCTTCCCTTT
AATCTGTTGGCTAGTACAACCG	CTTTCGGGGAGGACGCTCGCTGCG
AATCTGTTGGCTAGTACAACCT	TTATTGGATGTATTCTCTCCGTGCG
AATCTGTCCGCCAGTACAACCT	GGTTGTCCCTGGATGCCGCTGGAAAAAAAGCCCG
AATCTGTTGGCTAGTACAACCT

Protein	Signature genes	Signature genes Name	Protein_function
NC_015690.1\|WP_013916248.1\|2679020_2679374_+\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_041616835.1\|2696373_2698023_+\|alginate-lyase-family-protein	unknown	unknown	gnl\|CDD\|377511
NC_015690.1\|WP_013916255.1\|2682601_2683480_-\|NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224995
NC_015690.1\|WP_013916257.1\|2684474_2685818_+\|replication-initiation-protein	unknown	unknown	gnl\|CDD\|376444
NC_015690.1\|WP_013916266.1\|2695842_2696001_+\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013916263.1\|2692769_2693747_+\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380509
NC_015690.1\|WP_013916269.1\|2698263_2699268_+\|C40-family-peptidase	unknown	unknown	gnl\|CDD\|366353
NC_015690.1\|WP_013916247.1\|2676801_2678856_+\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|223910
NC_015690.1\|WP_013916250.1\|2680045_2680648_-\|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP	unknown	unknown	gnl\|CDD\|178955
NC_015690.1\|WP_013916262.1\|2691240_2692683_+\|glycoside-hydrolase-family-1-protein	unknown	unknown	gnl\|CDD\|225343
NC_015690.1\|WP_013916265.1\|2694700_2695708_-\|DUF3231-family-protein	unknown	unknown	gnl\|CDD\|371599
NC_015690.1\|WP_013916252.1\|2681022_2681688_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|378968
NC_015690.1\|WP_013916256.1\|2683680_2684250_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_015690.1\|WP_013916261.1\|2690621_2691014_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376293
NC_015690.1\|WP_013916260.1\|2689369_2690434_+\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NC_015690.1\|WP_013916264.1\|2694038_2694572_+\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|225168
NC_015690.1\|WP_013916259.1\|2687396_2688800_+\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_081473178.1\|2674147_2676676_+\|glycoside-hydrolase-family-2-protein	unknown	unknown	gnl\|CDD\|225789
NC_015690.1\|WP_013916251.1\|2680700_2681039_-\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_041617829.1\|2679528_2679744_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_015690.1\|WP_041616835.1\|2696373_2698023_+\|alginate-lyase-family-protein	gnl\|CDD\|377511	pfam05426, Alginate_lyase, Alginate lyase. This family contains several bacterial alginate lyase proteins. Alginate is a family of 1-4-linked copolymers of beta -D-mannuronic acid (M) and alpha -L-guluronic acid (G). It is produced by brown algae and by some bacteria belonging to the genera Azotobacter and Pseudomonas. Alginate lyases catalyze the depolymerization of alginates by beta -elimination, generating a molecule containing 4-deoxy-L-erythro-hex-4-enepyranosyluronate at the nonreducing end. This family adopts an all alpha fold.	1.27386e-35
NC_015690.1\|WP_013916255.1\|2682601_2683480_-\|NAD(P)-dependent-oxidoreductase	gnl\|CDD\|224995	COG2084, MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism].	3.39341e-30
NC_015690.1\|WP_013916257.1\|2684474_2685818_+\|replication-initiation-protein	gnl\|CDD\|376444	pfam01051, Rep_3, Initiator Replication protein. This protein is an initiator of plasmid replication. RepB possesses nicking-closing (topoisomerase I) like activity. It is also able to perform a strand transfer reaction on ssDNA that contains its target. This family also includes RepA which is an E.coli protein involved in plasmid replication. The RepA protein binds to DNA repeats that flank the repA gene.	4.2356e-05
NC_015690.1\|WP_013916269.1\|2698263_2699268_+\|C40-family-peptidase	gnl\|CDD\|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	2.37391e-23
NC_015690.1\|WP_013916263.1\|2692769_2693747_+\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|380509	cd06286, PBP1_CcpB-like, ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species. This group includes the ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species. Catabolite control protein B (CcpB) is 30% identical in sequence to CcpA which functions as the major transcriptional regulator of carbon catabolite repression/regulation (CCR), a process in which enzymes necessary for the metabolism of alternative sugars are inhibited in the presence of glucose. Like CcpA, the DNA-binding protein CcpB exerts its catabolite-repressing effect by a mechanism dependent on the presence of HPr(Ser-P), the small phosphocarrier proteins of the phosphoenolpyruvate-sugar phosphotransferase system, but with a less significant degree.	3.75335e-118
NC_015690.1\|WP_013916262.1\|2691240_2692683_+\|glycoside-hydrolase-family-1-protein	gnl\|CDD\|225343	COG2723, BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase [Carbohydrate transport and metabolism].	0
NC_015690.1\|WP_013916265.1\|2694700_2695708_-\|DUF3231-family-protein	gnl\|CDD\|371599	pfam11553, DUF3231, Protein of unknown function (DUF3231). This bacterial family of proteins has no known function.	3.90844e-53
NC_015690.1\|WP_013916252.1\|2681022_2681688_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|378968	pfam12840, HTH_20, Helix-turn-helix domain. This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.	1.77769e-08
NC_015690.1\|WP_013916256.1\|2683680_2684250_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.76819e-16
NC_015690.1\|WP_013916261.1\|2690621_2691014_+\|hypothetical-protein	gnl\|CDD\|376293	pfam00115, COX1, Cytochrome C and Quinol oxidase polypeptide I.	1.7121e-05
NC_015690.1\|WP_013916264.1\|2694038_2694572_+\|DoxX-family-protein	gnl\|CDD\|225168	COG2259, COG2259, Predicted membrane protein [Function unknown].	1.08808e-06
NC_015690.1\|WP_013916260.1\|2689369_2690434_+\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	6.65632e-40
NC_015690.1\|WP_081473178.1\|2674147_2676676_+\|glycoside-hydrolase-family-2-protein	gnl\|CDD\|225789	COG3250, LacZ, Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism].	1.25365e-96
NC_015690.1\|WP_013916247.1\|2676801_2678856_+\|HAMP-domain-containing-protein	gnl\|CDD\|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	1.52233e-53
NC_015690.1\|WP_013916250.1\|2680045_2680648_-\|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP	gnl\|CDD\|178955	PRK00277, clpP, ATP-dependent Clp protease proteolytic subunit; Reviewed.	3.74909e-140

>NC_015690.1|WP_013916257.1|2684474_2685818_+|replication-initiation-protein
MPRGKKTQDAGKAGTQQKSLAGKLIRELEMKGEETEAASSIDEQDTKPRSNTKPKVKSSIIRLADKAEAMAEKLIRQIEQSTNPDDVTSVEDLLKESASKLDSTKSYLTKDITEASVYLLQKLSQIVSETSSVVDNLSLTKNQYARQIIKLAKEMRERKKTQPMELNLMASNPFFTGIPNSYKEKVKETGLAEVVKNGTKTLEYQNSEGLYLSEFDKRVFTALTSIWVDQNCKQIFKFTEFELLRRLEMNPKGGMQHKRVRDSLRALTTTQIVIKEFYEKKNANRIVTSKFHLVASETTIEEYSKDDGKLQSREYQFQFADQIRQSFQDGYTTLISLGILDTLNTKTSRELYQLLCTIRDMAPQEQFKYTVEAGAFDVSLTEISEYMHLANNEYDNRRNILKACEELKEVYVLQDYVKLGTGRSCSAIRFYPGTLLKKEEVKVLTQG
>NC_015690.1|WP_013916256.1|2683680_2684250_-|TetR/AcrR-family-transcriptional-regulator
MSTAPTSSRQRLLDVASDLFYREGIRAISMDTIVERSGVSKATLYRHFPTKDELISAYLKAHDHHIWEHFDEAVAKHEGSPKDQLLALIDAIAELFQPEYYRGCPFLNAFAEFSDPHHPAHRLAMEYNHALRSRLSDLSRKAGVTDESWPDQLLLVINGAYSSVPVLGLTGSAAQLKKLTAQMIHQYVH
>NC_015690.1|WP_013916255.1|2682601_2683480_-|NAD(P)-dependent-oxidoreductase
MSEVSIIGLGPMGTALAQTFLKNDKRITIWNRTASKAESLVRQGAVLASSAASAINASPITIICVANYGSSASLLDTQEAASALAGRTLIQLSTGTPQEARNSEFWARERGAYYLDGAIQAWPSHIGAPETVILFSGSSTAFQTSEPLLRILAGNSIYLGEPVGSASAQALAVISYLLGTWLGFAHGAHILESEHLPVDSFGSMIAAIAPLLGEEAKHQGKVIQTGKFGNPESSLQTSADSVERLLQQATEAGINSDFPRFALPLFAKAAAAGYGDEEVSAIIKILRGGPAS
>NC_015690.1|WP_013916252.1|2681022_2681688_-|helix-turn-helix-domain-containing-protein
MTPHEPILESVLIDSPEQAMVLLNPLRAEIAARLSEPGSAAEVARAIGEAPQRINYHLKALEKAGLVRRVGSRQVRNLVEVLYQSIARTFVLSERLGMKPETVRKLKDQGSLAHLIGTADRIKQDALLLMEHSDEGEEVPSATLQFQVELATPERRQAFVEEYARLVQELTEKYGGDAAEGAYQVVVAVYPEASGRAAAPEGAQEKPAPKKRRKRIDGTQA
>NC_015690.1|WP_013916251.1|2680700_2681039_-|hypothetical-protein
MEHKPKKEFAAGTEEQRPGNAPQPAVVWESKSTAETAPPDRGQVSDLSAYRERKEAAAPDREATVTRWALPGRQKGDPAQWLIMVSSGFGAAPAVIHSGRGGAGDVKACLAA
>NC_015690.1|WP_013916250.1|2680045_2680648_-|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP
MNYIPMVVEQTGRGERSYDIYSRLLKDRIIFLGSAIDDTVANSIIAQLLLLSAEDPDKDIHLYINSPGGSTTAGLGILDTMQYIKPDVSTICVGMAASMAAVLLVSGAPGKRFALPHAEVMIHQPHGGSQGQASDIHIHAQRIVQTRELLNRIIAERSGQPFEKIERDTDRDYFMTAPAALEYGIIDKVLHSVQGTGAAS
>NC_015690.1|WP_041617829.1|2679528_2679744_-|hypothetical-protein
MESMCMNMMMTMCMEDMMGKMNCMKTMMNTMNEMNMTDCMDMNSMMMKMQQCDEMMTSMMETMRKMEQVSK
>NC_015690.1|WP_013916248.1|2679020_2679374_+|hypothetical-protein
MSLTARKDWEQAWVDDYLDLLNMAKRLQDTQWEQELLQTLQEYKRHTAAEIHYRFTQELWRRFDEINRRMLELYEKLKANRDQQENRLLQEQVWDLKLERIEVMRRIHSGENGIPAQ
>NC_015690.1|WP_013916247.1|2676801_2678856_+|HAMP-domain-containing-protein
MKHTAKGIISRVRNASLRVKLPILISLLVIAALLATSITTYIYSSNLVLRKSKDEINAMADRLGEGLWTSLQLQEQSTFLVSNHGTYRDLLKLREAGTLADADFFSARNPYFEKSNEILKTSLAGAKDTSSYLVVDPKGIIVSATTIENIGQSRADREYFTEALQGKSFVSDAIESKSTGKILLAFSVPIKDSDGRILGVFVTTVDSQFFVGKLGNVTINGEGGIEILSRGGTFLYSSKDPSIIGTKLQAEEFLKDRAAGEIKVISMDLDNQYLRINKIPGADLTITVLDTYADIERPINDMFKVIALITLVIILASIGFGLLLSRYMSKPLVEMAGLFKQLAQGDLTIKAEDKYDGEFKVLADSFNSMVSQNKDLITRMNQSIEVLHTSTNELEASSKQTASSINETSVTSVEIAKAMESQSHDTEHIVDKFYGFGEKFASMSAKARSVGERADEIIGVFHKSSEVVNELSHINQQNEEQVQKISAITAKLQESSDHISSITGAISDIANQTNLLALNASIEAARAGEHGRGFSVVASEIRRLAEQSSQQSNEIYAIIQQNLAFVAENNQSVSEIRTIALQQDEFVGQTQLAFQAILEKITEIADQIKGMTEEVARMERDKDEVLESAQSLSASGEEVSASVEEVTATMVEQSATVQQLADMVQTIDRLTRELAEAASRFKVE
>NC_015690.1|WP_081473178.1|2674147_2676676_+|glycoside-hydrolase-family-2-protein
MSLRRSKGLPLDGMGELGMKKIRDFSGTWQMRRRNEDTWMEAQVPGSVFADLMRSGRMGDPFFRDGVEQAKELARHEYEYKRSFTADEELLASDKILLVCDGLDTLAQIRLNGQPLAETDNMHRSYTFDVTAMLCPGLNTLHISFGSALLHAEQRHAEHPIWCTTVGATGGFNQIRKASYMFGWDWAPVLPDMGIWRNIRLEGYSAGRLSDVFVTQQHEPEGEVGLAVRIRSSLWTAEGVFAEVTLNGPDGEVLHRTAHACSGEDLTVDVLVAEPELWWPNGYGEQPLYELAVVLLGRAGQTLDERKLRIGLRTITWRREPDAWGESFECVVNGVPVFAKGANYVPQDSLLSRCTPERTERLIRDCTEAHFNMLRVWGGAFFPGDEFYDLCDRYGLLVWQDLLFACAAYEMTEAFTENIARETADNVIRIRHHACLALWCGNNEMEWAWVEWSLPKTGKLRSDYIKQFEMVLPAVVKTHDPQTFYWLASPSSGGGFDHPNDPSRGDVHYWDVWHGTKPFTDYRKSLFRFCTEFGFQSYPDLKTVESFTLPEDRNVFSYVMERHQTHPEANGKIMNYLAQLFKFPKDLDSLIYVSQLVQAEAIRYGVEYWRQNRGICMGSLYWQLNDCWPAASWSSIDYYGRWKALHYAAKRFYSPLCVSASERDLKVEIHVTNDMPEPAEGLLEWQLRDHRSRVLQEGGVWTTAAELASCCPLQLDFRGELTDSERRRCYLEYRWRNAEGEVLSRGTVLFVPSKHFELLPPQVDAEVEETADSFLVRVQSAAFARYVELTLRQTDGVASDNYIDLSAGEPREIFFPKDRLSVPLSLEAFRGQLRLRSLYDIE
>NC_015690.1|WP_013916259.1|2687396_2688800_+|hypothetical-protein
MIYKDTYHLMMNSLSSTEIDACLAMLLHVDWENRLRIEPEHLARQIGTTSKYMGDILRKFLREKKVLSKDRKDDTYAFRYGQSSLQYDERTTKYGKKFSLYYTPQFRSLSLNAKRLLIMALFRISETRDTEFHIPRLRLIRRSGQEGRLPLTGTQLLDVLQELRDAQIPGLSSAEIVQFQGEANVVIRFSDDIQQAYLENHTEMNLVKRELFRLGLHRLVPSDELCHALLSVGYHLFKSMLETDFAMNRREGEAEERRQGILRTARHMYNTALVRLAASFPAKRMELTNKDKLAAYFSAIVHEVMTQEMASCSYQVLQQESLLDYYMDKTKQEGITYGGPEVKALVLHIDGMKRMAAVLETVCQQWLLSRVATLSKDLSEAARSTQDQERILDRRGWTSIEEGKAQLRKLLKHEEELLAAMRAHVGSGVRVPARVLEEAMERYFVEIQTRAADLAAKNSRMNTEKTA
>NC_015690.1|WP_013916260.1|2689369_2690434_+|serine-hydrolase
MDHVIEEVMSDPKVLRWANRPAHQLTVGVLHPSGRKIWSSGGESGETNGTGRAYEIGSITKTMTGLMLAAGEQQALWSRSDRLSDVNLDLAASPFAKQTTLLDLVTHTSGLPDVPGNFKASITDRLNPYANYDEARLIEAVLAEKPKSGSRHRYSNYGFGLLGWLLSRRLGTTLDDALTRQVFHPLGMPDTYAGGRTPAPAQLLPVYNSKGKVLPPWDFHEAMGGAGAVRSTAADMLNYLEAHVHPDSHSLSPAVEEGLKEHYAIMPSRGIGIGYGWMRYREKDGTVTHWHNGGTYGSSSFIAFNRSKGAGVVILSNNGSTMWSQLAPMLGLRLLSVDALATRLTKKLFAASAG
>NC_015690.1|WP_013916261.1|2690621_2691014_+|hypothetical-protein
MGKTFIKIAAVYFGVGVSLGLMMGILHNFSLTSVHAHINLLGWVSMALFGLIYHVYPKAAQTRIAKLHFWLYNIAFPMMQVAIALQITIPTVPVFLPVTIVSSMAVVISVLLFGWNLFRQLTDTSAPRAR
>NC_015690.1|WP_013916262.1|2691240_2692683_+|glycoside-hydrolase-family-1-protein
MIHTQVRPFPQDFLWGSASAAYQIEGAWNEDGKGPSVWDVFTKIEGTTYKGSNGDVAMDHYHRYREDIALMAEMGLKAYRFSVSWPRIYPSGHGEVNEAGLQFYDNLIDELLAHGIEPVLTLYHWDVPQALMDEYGAWESRRIIEDFDNYCITLFKRYGDRVKYWVSLNEQNYNTNHGFITAMHPPGVKDRKRFYQANHHAFLANAKVIDSFRHYVPHGKIGPSFAYSPAYPASSKPEDLLAFENAEEFTNYWWLDVYCLGQYPQIPLRYLEEQGLAPVFEEGDLELLRRGRPDFVGVNYYQTITYETNPLDGVAEGRMNTTGQKGSNQSTGMPGLFKTAANPNLETSNWDWAIDPIGLRIGMRRITSRYGLPVFITENGLGEFDKLEADDTVHDDYRIAYLRSHLLQCQQAISDGVELIGYCSWSFTDVLSWLNGYQKRYGFVYIDRDETDARSLRRIKKLSFHWYREVIRTGGEHLLK
>NC_015690.1|WP_013916263.1|2692769_2693747_+|LacI-family-DNA-binding-transcriptional-regulator
MANIREIAKAAGVSVATVSRVLNGHPYVSAEKRRRVEEAMRRAGYSPNSNAVHLSTGRTGMVGVILPFSHHPYFHALLGGLMEEALKHQYTALLCQTNYEAGEERRYLQMLRTKQVDGLILCSHELPWAEIAAYAADGLLVACEPVRQEGISCVYTHHYEAFLTGMRYLIRRGHRNIGFCIGRRDSESSRQRYAAYADAMQEIGRPVQPEWIFEGCTDLRDGMRVMDRIAAMESRPSALLVTGDEAAAGVLARSRQLGIAIPGELAIVGFDNQPISEALQLTTIDQHLQEIGRQAFGAFYHGIVQPGAAPRRMEVPFELVERTSV
>NC_015690.1|WP_013916264.1|2694038_2694572_+|DoxX-family-protein
MLTRFLRDNVYAAGLLLILRLYVGYQWFTAGFHKLTGGFDAAGFLKGAIAKPVLDKATGELVYPTFTAFLQNFALPNVKVINFLIPAGETLVGLGLILGALTTAAAFFGLLMNFMFLFAGTVSTNPWLVLLGVIVLMAGTNAGRFGVDRYLMPLLRKLRRQGGGDEAGRRKGIPAKA
>NC_015690.1|WP_013916265.1|2694700_2695708_-|DUF3231-family-protein
METAHNIPLTAPEISNLWSGYQGDTLSRCVLTHFAAHVEDTEVRELIAYALELCDKHITRQLSYFETEKIPVPQGFGDEDVDPKAPRLFSDIFYLGYLLNMGKQGMTLYAYSVPVSSRQDIREYLSECLASSSALYNRTLDLMLAKGVYVRPPRIPVPEAREYVHKESYFYALIEDKRPVNGPEIAHLYANIVTNLMGKALTLGFAQTAVSKDIRAYLLRGHEISGKHVEVFRSLLRDDGLPAPNYWDDGVTASTTPPYSDRLMMYHIGALSATGAVNYGVAAPNSTRRDITSVYVRLIGEIAKYGEDGAELMLKHQWMEKIPGAVERGSLVRRS
>NC_015690.1|WP_013916266.1|2695842_2696001_+|hypothetical-protein
MLNQLILWSLLIIPWFSLLFMDTTKLRRFFPVALLVTVINTLFYQAASTKWS
>NC_015690.1|WP_041616835.1|2696373_2698023_+|alginate-lyase-family-protein
MRNQGRRKLPVLAAAGLAAGLVFSSAAAAYPHPGGMHSEAQLASAKRNIAGGLQPWADAMKELIPRADFYLLEPPSASADFHVPGYYEDPAGHTGASEVLHTDVRAAYASALAYRLTGRTAYAEKAKAILNDWAFRNTAVSGTDGPLVMTYSGVGFIHAAELLRDYSGWSEADKTAFSNWLTNVYLARAANPIKTRSNNWGDWGIYGAMAAYYYKDDPVLLNAEITRLKNKIDSSIAADGSMPHEAGRGASGLWYTYFALAPMTAAAQIAKEAAGIDLFQWTSPGGRTIKQALDYLLFYMNRPDQWPYGANPRMPVSDEEWGYNLFEAMSDYYDEPAYKSFASVKGPIMYLASHFAWNFPSVTKGGLRLVDEKFDALTSTAAPRGWTVSKAANTSAVVWNTPTAADKSLKIWDTSTSGTASAVKVFPDQYGIIEAEWKFMYMALFPNARFGLKHAAVYAAELLTTASRLIYRSGTGSDIALQTLSPDAWYTVKLIANPASDKTDVYVNGQLKASGVPFRSTVSALDRIEFAGGSGETGTFYIDQVKIMN
>NC_015690.1|WP_013916269.1|2698263_2699268_+|C40-family-peptidase
MKRIITAASAALIAGVFALPQGQAQAATTSTIVSDVSFRKAPDTDAARIRYLQEDEKVTVVSKVNDYWYKVTDKNGVTGYVSSSSKYISAPRTTSTGTAAASNTGKIVSGVSFRKAADTDAARIRYLQEGETVTILDKVNSYWYKVKDKNGVTGYVSTSSKYISASYKGTASAAPAGTTSGGTSSSTTSTQKVEKVIAAGMKYLGTPYEYGSDRSTVATFDCSDFVRQAFKDALGVTLPSNSRTQADYVREHSSRIVTDIDNLKRGDLVFFMSYRGSSLSAYSGMDKSAQRITHVGIYLGDGKMLNTWGTGGVKVDTITGRHWEGRFIFGGSAL

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Crispr_ID: NC_015690_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015690_15

2739666-2739861

Orphan

Consensus_repeat	Method
AACACGGAAAATCCGTGTTAG	PILER-CR

3 spacers

The CRISPR arrays of NC_015690_15

>merge|NC_015690|15|2739666-2739861|PILER-CR
AACGCGGAAAATCCGTGTTAGCGGCGCCGCATTGAGGCTTCAGCCGCTGCTTTGCTCCCTCGAACACGGAAAATCCGTGTTGGGAGCGGCAAATGCAGCGAATAAACCGGTTTAACACGGAAAATCTGTGTTAGCGGCACCGCATCGAGCCGTCAGCCGCTGCTTTACTCCTTCGAACACGGAAAATCCGTGTTGG

>NC_015690|15|5|2739666-2739861|PILER-CR
AACGCGGAAAATCCGTGTTAG	CGGCGCCGCATTGAGGCTTCAGCCGCTGCTTTGCTCCCTCG
AACACGGAAAATCCGTGTTGG	GAGCGGCAAATGCAGCGAATAAACCGGTTT
AACACGGAAAATCTGTGTTAG	CGGCACCGCATCGAGCCGTCAGCCGCTGCTTTACTCCTTCG
AACACGGAAAATCCGTGTTGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_015690.1\|WP_041616849.1\|2728312_2729200_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|225117
NC_015690.1\|WP_013916304.1\|2736034_2736715_+\|CoA-transferase-subunit-B	unknown	unknown	gnl\|CDD\|188219
NC_015690.1\|WP_013916300.1\|2731867_2732758_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176129
NC_015690.1\|WP_013916301.1\|2732948_2734328_+\|GntP-family-permease	unknown	unknown	gnl\|CDD\|225330
NC_015690.1\|WP_013916312.1\|2745708_2746974_+\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013916315.1\|2748219_2749167_+\|phosphate/phosphite/phosphonate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270290
NC_015690.1\|WP_013916299.1\|2730740_2731553_+\|AbrB-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|377472
NC_015690.1\|WP_187296768.1\|2734404_2735181_+\|3-hydroxybutyrate-dehydrogenase	unknown	unknown	gnl\|CDD\|237100
NC_015690.1\|WP_013916313.1\|2747345_2747576_+\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013916308.1\|2740365_2741658_-\|NCS2-family-permease	unknown	unknown	gnl\|CDD\|225161
NC_015690.1\|WP_013916316.1\|2749202_2749949_+\|phosphonate-ABC-transporter,-permease-protein-PhnE	unknown	unknown	gnl\|CDD\|273441
NC_015690.1\|WP_013916309.1\|2741980_2742949_-\|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	unknown	unknown	gnl\|CDD\|133463
NC_015690.1\|WP_013916314.1\|2747735_2748026_+\|DUF3817-domain-containing-protein	unknown	unknown	gnl\|CDD\|378962
NC_015690.1\|WP_013916303.1\|2735223_2735931_+\|CoA-transferase-subunit-A	unknown	unknown	gnl\|CDD\|224702
NC_015690.1\|WP_013916298.1\|2729355_2730645_+\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NC_015690.1\|WP_013916317.1\|2749950_2750760_+\|phosphonate-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213223
NC_015690.1\|WP_013916296.1\|2726347_2727463_+\|aminopeptidase	unknown	unknown	gnl\|CDD\|225191
NC_015690.1\|WP_014369965.1\|2744166_2745669_+\|tagaturonate-epimerase-family-protein	unknown	unknown	gnl\|CDD\|379807
NC_015690.1\|WP_014369964.1\|2743157_2744012_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NC_015690.1\|WP_013916307.1\|2738173_2739385_+\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035

Protein	Function_ID	Function_description	E-value
NC_015690.1\|WP_041616849.1\|2728312_2729200_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	1.33164e-30
NC_015690.1\|WP_013916304.1\|2736034_2736715_+\|CoA-transferase-subunit-B	gnl\|CDD\|188219	TIGR02428, 3-oxoadipate_CoA-transferase_subunit_B, 3-oxoacid CoA-transferase, B subunit. Various members of this family are characterized as the B subunits of succinyl-CoA:3-ketoacid-CoA transferase (EC 2.8.3.5), beta-ketoadipate:succinyl-CoA transferase (EC 2.8.3.6), acetyl-CoA:acetoacetate CoA transferase (EC 2.8.3.8), and butyrate-acetoacetate CoA-transferase (EC 2.8.3.9). This represents a very distinct clade with strong sequence conservation within the larger family defined by pfam01144. The A subunit represents a different clade in pfam01144.	2.61138e-118
NC_015690.1\|WP_013916300.1\|2731867_2732758_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176129	cd08438, PBP2_CidR, The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold. This CD includes the substrate binding domain of CidR which positively up-regulates the expression of cidABC operon in the presence of acetic acid produced by the metabolism of excess glucose. The CidR affects the control of murein hydrolase activity by enhancing cidABC expression in the presence of acetic acid. Thus, up-regulation of cidABC expression results in increased murein hydrolase activity. This substrate binding domain has significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.09127e-83
NC_015690.1\|WP_013916301.1\|2732948_2734328_+\|GntP-family-permease	gnl\|CDD\|225330	COG2610, GntT, H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism].	1.39785e-82
NC_015690.1\|WP_013916315.1\|2748219_2749167_+\|phosphate/phosphite/phosphonate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270290	cd13572, PBP2_PnhD_2, Substrate binding domain of uncharacterized ABC-type phosphonate-like transporter; contains the type 2 periplasmic binding fold. This subfamily includes putative periplasmic binding component of an ABC transport system similar to alkylphosphonate binding domain PnhD. These domains are found in PnhD-like proteins that are predicted to function as initial receptors in hypophosphite, phosphonate, or phosphate ABC transport in archaea and eubacteria. They belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.83649e-87
NC_015690.1\|WP_013916299.1\|2730740_2731553_+\|AbrB-family-transcriptional-regulator	gnl\|CDD\|377472	pfam05145, AbrB, Transition state regulatory protein AbrB. Bacillus subtilis respond to a multitude of environmental stimuli by using transcription factors called transition state regulators (TSRs). They play an essential role in cell survival by regulating spore formation, competence, and biofilm development. AbrB is one of the most known TSRs, acting as a pleotropic regulator for over 60 different genes where it directly binds to their promoter or regulatory regions. Many other genes are indirectly controlled by AbrB since it is a regulator of other regulatory proteins, including ScoC, Abh, SinR and SigH. Hence, AbrB is considered a global regulatory protein controlling processes such as Bacillus subtilis growth and cell division as well as production of extracellular degradative enzymes, nitrogen utilization and amino acid metabolism, motility, synthesis of antibiotics and their resistant determinants, development of competence, transport systems, oxidative stress response, phosphate metabolism, cell surface components and sporulation. AbrB is a tetramer consisting of identical 94 residue monomers. Its DNA-binding function resides solely in the N-terminal domain (AbrBN) of 53 residues. Although it does not recognize a well-defined DNA base-pairing sequence, instead, it appears to target a very weak pseudo consensus nucleotide sequence, TGGNA-5bp-TGGNA, which allows it to be rather promiscuous in binding. The N-terminal domains of very similar sequences are present in two more Bacillus subtilis proteins, Abh and SpoVT. Mutagenesis studies suggest that the role of the C-terminal domain is in forming multimers.	1.36208e-34
NC_015690.1\|WP_187296768.1\|2734404_2735181_+\|3-hydroxybutyrate-dehydrogenase	gnl\|CDD\|237100	PRK12429, PRK12429, 3-hydroxybutyrate dehydrogenase; Provisional.	2.30436e-148
NC_015690.1\|WP_013916308.1\|2740365_2741658_-\|NCS2-family-permease	gnl\|CDD\|225161	COG2252, COG2252, Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism].	1.93346e-140
NC_015690.1\|WP_013916316.1\|2749202_2749949_+\|phosphonate-ABC-transporter,-permease-protein-PhnE	gnl\|CDD\|273441	TIGR01097, PhnE, phosphonate ABC transporter, permease protein PhnE. Phosphonates are a class of compound analogous to organic phosphates, but in which the C-O-P linkage is replaced by a direct, stable C-P bond. Some bacteria can utilize phosphonates as a source of phosphorus. This family consists of permease proteins of known or predicted phosphonate ABC transporters. Often this protein is found as a duplicated pair, occasionally as a fused pair. Certain "second" copies score in between the trusted and noise cutoff and should be considered true hits (by context). [Transport and binding proteins, Anions].	1.17287e-72
NC_015690.1\|WP_013916309.1\|2741980_2742949_-\|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	gnl\|CDD\|133463	cd06853, GT_WecA_like, This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate molecule and N-acetylglucosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylglucosamine precursor. WecA participates in the biosynthesis of O antigen LPS in many enteric bacteria and is also involved in the biosynthesis of enterobacterial common antigen. A conserved short sequence motif and a conserved arginine at a cytosolic loop of this integral membrane protein were shown to be critical in recognition of substrate UDP-N-acetylglucosamine.	1.87562e-81
NC_015690.1\|WP_013916314.1\|2747735_2748026_+\|DUF3817-domain-containing-protein	gnl\|CDD\|378962	pfam12823, DUF3817, Domain of unknown function (DUF3817). This domain is of unknown function. It is sometimes found adjacent to pfam07690 and pfam03176 which are both transporter domains.	2.91066e-28
NC_015690.1\|WP_013916303.1\|2735223_2735931_+\|CoA-transferase-subunit-A	gnl\|CDD\|224702	COG1788, AtoD, Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism].	4.52126e-108
NC_015690.1\|WP_013916298.1\|2729355_2730645_+\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	1.07118e-38
NC_015690.1\|WP_013916317.1\|2749950_2750760_+\|phosphonate-ABC-transporter-ATP-binding-protein	gnl\|CDD\|213223	cd03256, ABC_PhnC_transporter, ATP-binding cassette domain of the binding protein-dependent phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all kingdoms of wildlife, but only prokaryotic microorganisms are able to cleave this bond. Certain bacteria such as E. coli can use alkylphosphonates as a phosphorus source. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	8.1933e-111
NC_015690.1\|WP_013916296.1\|2726347_2727463_+\|aminopeptidase	gnl\|CDD\|225191	COG2309, AmpS, Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism].	1.38489e-113
NC_015690.1\|WP_014369965.1\|2744166_2745669_+\|tagaturonate-epimerase-family-protein	gnl\|CDD\|379807	pfam16257, UxaE, tagaturonate epimerase. This family consists of uncharacterized proteins around 500 residues in length and is mainly found in various Bacteria species, such as Thermotoga, Paenibacillus and Rhodothermus. A newly recognized enzyme from the galacturonate utilization pathway in T. maritima with tagaturonate epimerase activity.	0
NC_015690.1\|WP_014369964.1\|2743157_2744012_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	9.9318e-28
NC_015690.1\|WP_013916307.1\|2738173_2739385_+\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	3.62842e-101

>NC_015690.1|WP_013916307.1|2738173_2739385_+|cytochrome-P450
MSLDVGLDMSSPEFKNRAYALYDRWRVEEPVHSMGTTGGQQAWLITRYDDAVEALKNEERFTKNNRSLQAPGEPGLLPDKVFGLINNNLLGSDPPDHTRLRSIVSKAFTPGVAESLRGQIEEITGRLIGELRQKGGGDLIDEFAFPLPIYVICQMLGIPPEDHALFRKWSDDFIAAATDIEKIRGVQSSLEAFASYVNGLIEERKAKPQADLITELIRVQENGDRLTREELSSTIFLLIVAGHETTVNLIGNGTLALLEHPDQLALWRGIPDLDSTAVEELLRFYGPVEISTNRWVREPFEWHGKQLQRGDLLFVSLASANRDPSQFEDPARLDLTRKKNRHIAFGSGIHFCLGAPLARLEGSIAISTLIRELPNLRFAVPREEIHWRRGRLMRGLQSLPVLV
>NC_015690.1|WP_013916304.1|2736034_2736715_+|CoA-transferase-subunit-B
MKGQREIIVARAVREVRDGMYVNLGIGMPTLVAGAIPEGMNVMLQSENGLLGIGPYPYEGEEDPDLINAGKETVTAVRGASFFDSAESFAMIRGGHIDLAILGGMEVAENGDLANWMIPGLMVKGMGGAMDLVSGAKRIVVIMEHVNKHGQSKVRKACTLPLTGSGVVDRLITDLAVFDFTPEGMRLIELQPGVTLDEVRQRTEAAYTVAPELLGGEAAVKGGAVG
>NC_015690.1|WP_013916303.1|2735223_2735931_+|CoA-transferase-subunit-A
MDKRVASMEEAVRDIADGSLLVVGGFGLCGIPEGLIRALQTQGTKGLTVVSNNCGVDDAGLGLLLAGRQIRRMVSSYVGENKTFERQVLSGELELELVPQGTLAERIRAGGAGIPGFYTPTGVGTVVAEGKEHKSFDGRTFVLERGIVGDFALVKAWKADTLGNLVYRRTSRNFNPLAAAAGRITIAEAEIIVEAGELDPDEIHTPGIYVQRVVQGTAEGKRIERRTVRAKEGTA
>NC_015690.1|WP_187296768.1|2734404_2735181_+|3-hydroxybutyrate-dehydrogenase
MLRDRTALITGAASGIGLEIARTFAKEGARVVVTDIRTEGALQAASLLQDEGFEALGLRCDVTQEGEYAAALQAADETYGSLDILVNNAGLQHVAPLEDFPVDKFEFMIKVMLTGAFIGIKHAFPLMKRGGYGRIINMASINGVIGFAGKAAYNSAKHGLIGLTKVAALEGASHGITVNALCPGYVDTPLVRGQLEDLARTRGVPLESVLEEVIYPLVPQRRLLTVEEIADYAVLIASDKLRGVTGASLLIDGGYTAQ
>NC_015690.1|WP_013916301.1|2732948_2734328_+|GntP-family-permease
MILQVLAIVLALGLLMFFAYRGYPVIVFAPVFTLLAVVISGNALLPSYTETYMSNAANYVKSFFPIFLLGAIFGKVMELSGAASSIAQTIVRALGSQRAILSVVAACAVLTYGGVSLFVVAFAVYPFAVAIFREADIPKRLIPGTIALGAFTFTMDALPGTPQIQNIIPTTYFGTDAYAAPLLGTIGGLMVLAGGLFWLERRRKEAAQAGEGYGTGHKNEPEVLENQTYPNIWIAVLPLVLVLLFNYLLSRGALTVNNWYSAELLKSFNIANVKTVSSSWALIIALCIGIAAALCINVRAVQGKLAAGLTAAAMGSLLAIFNTASEVGFGNVVKTLPGFKLIQNWILGISDNPLISEAVSVNILAGVTGSASGGLSIALEVMGKTYLTAAQAAGISPELLHRIASMASGGMDTLPHNGAVITLLAITGLTHRQAYKDIFAITVVKTVTVFVLAIVLSMF
>NC_015690.1|WP_013916300.1|2731867_2732758_-|LysR-family-transcriptional-regulator
MDIRQLAYLLEIAKHQNITKAAEALHMTQPTLSKIVKAVEEELGVTLFDRSGKSVRLTDAGEAAVAQIHSVLQAFEGLHTALGDVVQLKKGLIRIGLPPVIGSVFFPRILAGFRAKHPHIDFDLVEEGANKVESLLLEGVLDMGVVVSPVDPESFDTLPFLYQQLALVIHESHPLAAQPSVRLEELRGEPFVLFPRGFAVRRHVMRACRDLGFEPSIVYESSQWDLLAEMVAARVGVSIIPQAICSKITNPDVRTLALTDPVIPWNLEVIWPKSKYVSYAMREFQAYIREVSGPQP
>NC_015690.1|WP_013916299.1|2730740_2731553_+|AbrB-family-transcriptional-regulator
MMTRLLMTLAVTAPGGLLFSWLHLPLSWMLGPLTAAVLWQSLIAGADRPLVWPVAFIFAVPFLAVHGLAGPAAPVSAVPLPAPDAAAAHPFGLTAAVVLIPLAALGAVRLKLPTPWFLGPMLASAGLTIAGLAPPHLPAPLLLAAQWSLGIYLGLGIKLSGLAGWRRLLPYSLLTGAGLVLFSLGLSWVYSLLLPMTTATAFLSTSPGGMTEMGVVASVIGADVSLVVAFQMFRILFILFAVPYLLRWGFRRAAARREEGAPAKPERPGA
>NC_015690.1|WP_013916298.1|2729355_2730645_+|Gfo/Idh/MocA-family-oxidoreductase
MTDQRKTYALVGTGGRAAFFYKAIVSDFKETSQLIAFCDVNQTRMNYANKQITDLGAEPVPTYKAHEFDRMIGETKPDVVIVTSVDRTHHTYIIRAMELGCDVMTEKPMTVDEDKCQEILDAVKRTGRQLRVTFNYRYSPHNTKIRELIEDGVIGDVHSVHFEWLLNTKHGADYFRRWHRDKRNSGGLLVHKSTHHFDLVNFWLNTQPQTVFALGDLMFYGKENAEKRGVTEFYQRATGSKNAENDHFALHLDKNESLKGMYLDAEHEDGYQRDQSVFGEGISIEDTMGVMVQYKNRAILTYNLYAYAPWEGFRVAFNGTKGRIEMEVVESSYVNSGGDQALEGAVVGKKIIVHPIFEAPYEVQVKEGKGGHGGGDPVLLNDLFGTPEPDRFNRAASHVDGAMSILTGIAGNRSLRTGQPVRVSELVRF
>NC_015690.1|WP_041616849.1|2728312_2729200_-|helix-turn-helix-domain-containing-protein
MTPTDTPRVPSVHLTDEPAFILNHTHRSASFNMESNHSHDSYEIYYMQSGSRYYFIKDRSYLVREGDLVLIEPSVLHRTTEAHSSEHERILINFKPEWLGSLLPAMEPDLLEAFGRVPVVRPEPKDRQRIELLLTTMLAEQSHPDEPGAGSALKLYLAELLLWLYRWRLKEQAAENGGRSEHPTSLHRKVSDIVQHINASFHEELSLQVLADRFHISPYYLCRIFKEATGFTLVEYIQRLRVHEARKLLAGTSMRITEVAGEVGFDSSTHFGRVFKAICGLSPLQYRKSIEGGAK
>NC_015690.1|WP_013916296.1|2726347_2727463_+|aminopeptidase
MRDPRLKELAHNLVRYSVNLQPGENILIEAIGLRDQELTKCIIEEVYAAGGHPFVEYRDPAVTRALMLGGSLELYRQMAEIEVERMKKMQAYLGIRSGDNITETSDVPEDKLKLYFKEYQRPVTDQRVNHTKWTIMRYPNASMAQLANTSTEAFEDFYFRVCNLDYSKMSAAMDSLVELMEKTDKVRLVGEGTDLSFSIKGIPAIKCAGEFNIPDGEVFTAPVKDSVNGVISYNAPTIYQGTVFEKVVLRFENGRIVEATANETKKLNDILDSDEGARYIGEFAIGVNPHIQHPMKDILFDEKIDGSIHFTPGNAYESADNGNRSSVHWDMVLIQRPEYGGGEIYFDDRLIRKDGRFVVPELEKLNPENLK
>NC_015690.1|WP_013916308.1|2740365_2741658_-|NCS2-family-permease
MLAQWFQLNERQSNVRTEVTAGLTTFLTMVYIVIVNPAILSASGIPFGQVFTATVCAAVIGTLYMALFANHPIAVAPGMGMNAYFTSVVASQGVTYQAVLGTVFLAGVLFLLLSFTKLRETLIASIPASIKYGITAGIGLFIAFIGLRMSGIVTASPATLVALGDLSRPGTLLTIFGLLLTLVLMARRVKAALFIGMAVTAAAGYALGLLQFKGIAALPAAPVLFDLDVAGVFSSGLYTVVFAFLLVTIFDTTGTMIGVAEQAGLVRGGVFPRAKQALMADAVATVAGSLLGTSPSSAYVESSAGVAAGGRTGLTSLTVAVLFLLSLFFAPVVEALSSLSAITAPVLIIVGCFMMEGLAKIEWDTFDEAFPAFAILIAMPLTSSIATGIAIGFITYPLLKLVTGKGRSVHPLLYVFGVIFLVQMTFFPAH
>NC_015690.1|WP_013916309.1|2741980_2742949_-|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase
MYLYSYAAAFVMSFVIVLALIPPLRRWAFRIDFVDKPRPDQERKIHREPIPMMAALAIFAGFACTYLLFANDDWTQTTAILAGSLLILGIGTLDDWYKTRGKELAAWPKMLVQMAAAVIVYQSGIVFYGFNNPLTGQDFILWEWLQFALTVLWIFGVTTVINFTDGMDGLAGGISAISAGTLFVVAAAKGQEDSAILAIILVGASLAYLRYNKPPARVFMGDAGATLLGFLLGVIALDGAFKQATVLSLLIPILALGVPIFDNLFVVFKRWRSGKPIYMADASQAHYRLLRSGLNQKQVVMVLCLLNVCFGLTSIILLLLRV
>NC_015690.1|WP_014369964.1|2743157_2744012_-|AraC-family-transcriptional-regulator
MSETVTLHYGEEEGDFHIEHVRRTEPFARTNHWHGTYEIYYQLSGQRAYFIKDRTFLISPGDLVFIGKHQVHKTSDVGLPGHERVVINFSDRFIGGDREHPLSHPAMLAAFQSPSRVFSLKLPDQIFVQNILQKMAKEIKERATGYEIYVKLLLLELLLFSGRYSERAETTAIEHQSPVHKKISEIVRHINANYQEPMTLTGLSEQFFMSPYYLSRAFKEVTGFTFVEYVNTTRIREAQRLLKESNKKIIEIAELTGFENIAHFGRTFKKLARMTPLEYRKGER
>NC_015690.1|WP_014369965.1|2744166_2745669_+|tagaturonate-epimerase-family-protein
MSKWGTIAEALRAGTVAGVNAEGVKVYAQSLTENETTKLVMVKDTAAHTKYIAAAGEGALYDELQGEVQDGVKLAPLTHENRLVLNKYFDYTVPRAFGTQIATIGLGDRLGIASPGHIKTVRGRNIRPILAQQSIRELALTGRDYKQVVDAACFAVFQEGYKDGFGADGDHLKVEADIELALGLGFTMLTLDCSEKIDNNVEGTSAEEQAAKYAALPAEVREHYENRFLNQTFQVAGGEITFDRETLIKNVLIYAAAVDFMEHIYNTYITKADREIDFEISIDETMTPTAPESHFFVAKELYSRGLTIYSMAPRFIGEFQKGIDYIGDIAQFEKELAVHAGIADDFGYKLSIHSGSDKFSVFPLIGQYTKGRFHVKTAGTNWLEAVRTVAKVNPSLYRAMHAYALEHFEEATAYYHVTTDLSKIAPLDGVADADLADTYMNEDNARQLIHITYGILLQAKNEQGGSLFRDDFYRTLSEQEEAYEESLRSHIGKHLDLLGK
>NC_015690.1|WP_013916312.1|2745708_2746974_+|hypothetical-protein
MGVRTKEALRELVRKTVRAVPVTDAFTELYPEAFGSLMRWGLDGLLTSRALLEEAVRFHPGLTEEASSLPRPAAAELVWQTLFLDRTPLSPACREVVAVLHALGWDGRRKRLSAWRDCYDDLTAADYLDLVFARSGVTTVCMLSDPLNDAEGQVWERLHALDPRFNPVLSVDLLLRDWKKACACLRAKDYAAAEQLDNGTLEAVRSYLRYSIVRLNPLYLAASLPDGYANGGASDADRLLRECILPVAGEAGIPLGIRLEVPGPLSGGSRRAQDGEGSAEFSVLLELCRRHPGQKFLALVSGAELTLPELKAASCMPNLHLAGCAAAGTPGRGAAVRLQGCLDMLGLTMTPIYSGAEAADLLLPAWEQGRSLLESVLCERYAALADAGWSISAEDVERDAAELLGGAFWRFLGRPNPATGL
>NC_015690.1|WP_013916313.1|2747345_2747576_+|hypothetical-protein
MTQHFAAMPLVAHIPDGQPGWRLVHCPECGAACWERPDIAEAKRVIPDLTECCTECAQKAGLPLDGTQIEGGEGVR
>NC_015690.1|WP_013916314.1|2747735_2748026_+|DUF3817-domain-containing-protein
MTMRTPIGRLRVVGLLEGISFLLLLGIAMPLKYMLDLPQMVSVVGMAHGVLFVAYLLAVAHVTFVHRWSLLKVLFAVIASFLPFGTFVLDARLKRS
>NC_015690.1|WP_013916315.1|2748219_2749167_+|phosphate/phosphite/phosphonate-ABC-transporter-substrate-binding-protein
MFWKRKPFLVLTFLLIAGMLLGACGKKASNEGQQAAEGNGQGTAATEQGEFLIGVIPAQGSNQMKTGADKLAAILSEKLGRKVRAEVYPDYNGVVEAMGAGKAHMAYLGPLTYVEAHERYNVKAVVTQLINGKPFYYAYMIAPSDSPYATLDDVIKDSKNVRFAFGDISSTSGSLIPGIALKKAGVFETQQKHQFKSVTYTGDHLATALAVQNKTQDVGAIDSAYFNRLVKDGKVDGTKIKQIWQSEELFQYPWAVIESTPEKDVKIIQDAMVAITDKDILDAFGGASGFTVAKNEDYAAIRQAAIADGRVKPKQ
>NC_015690.1|WP_013916316.1|2749202_2749949_+|phosphonate-ABC-transporter,-permease-protein-PhnE
MNKILLLALAVLLLIWSGRGVGFDIALFRDLGNTYRFITEQWFPLDPADYEIALQAAVETLQISLFSTMIAIGIALPASFFAARNSTPARWLYDGFRFVFNLFRAIPELVLALLFIPTLGLGPLPAVMALIIHNTGVFGKMISETIEAIDRGPQEAVQSVGGTRLLVSLYGILPQIVPLVISHFFYRLEVAIRTCLILGVVGAGGLGQLLYNDFKQFMYQKVAFEVLLIMILVTGVDYLGAFIRKRVS
>NC_015690.1|WP_013916317.1|2749950_2750760_+|phosphonate-ABC-transporter-ATP-binding-protein
MNGKRTPAENRGGAPAHAGLEIRGLTKQYPGAKEAALQDVTLTVRPGEWVAVLGRSGAGKSSLIRCINRLIEPDSGEIRWAGQPVTGVSGSELRRLRGDIGMIFQHYNLLPRLSVLTNVIAGRFADIPLRQSLLGVFSGAYKAQAMEALRSVGLAHLAGRKVEALSGGQRQRVAIARVLMQDPQLLLGDEPVSSLDPVTAVRVLDFIGTLHRRGMTVVTNLHDVHAARRYATRIIGLAHGGIVFDGPPEELGEAELQRIYPPDDDKLQP

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Crispr_ID: NC_015690_16

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015690_16

3026481-3026568

Orphan

Consensus_repeat	Method
AGTGACCTTTGAACGAAGTTGAACGGAAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015690_16

>merge|NC_015690|16|3026481-3026568|CRISPRCasFinder
AGTGACCTTTGAACGAAGTTGAACGGAACTTAATACAGAGCGAGATATTTCATTTTGAAAGTGACCTTTGAACGAAGTTCAACGGAAC

>NC_015690|16|10|3026481-3026568|CRISPRCasFinder
AGTGACCTTTGAACGAAGTTGAACGGAAC	TTAATACAGAGCGAGATATTTCATTTTGAA
AGTGACCTTTGAACGAAGTTCAACGGAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015690.1\|WP_013916618.1\|3031644_3031887_+\|RNA-chaperone-Hfq	unknown	unknown	gnl\|CDD\|379947
NC_015690.1\|WP_013916610.1\|3020022_3020988_+\|membrane-protein	unknown	unknown	gnl\|CDD\|378698
NC_015690.1\|WP_013916613.1\|3023509_3026287_+\|DNA-mismatch-repair-protein-MutS	unknown	unknown	gnl\|CDD\|235444
NC_015690.1\|WP_013916622.1\|3036506_3036902_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319908
NC_015690.1\|WP_013916614.1\|3026604_3028068_+\|PDZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|223864
NC_015690.1\|WP_016362588.1\|3018579_3019356_+\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013916609.1\|3017602_3018451_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223673
NC_015690.1\|WP_013916612.1\|3021829_3023308_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|373045
NC_015690.1\|WP_014370096.1\|3034927_3035626_+\|peptidylprolyl-isomerase	unknown	unknown	gnl\|CDD\|238194
NC_015690.1\|WP_013916608.1\|3016815_3017610_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213260
NC_015690.1\|WP_013916623.1\|3036892_3037564_+\|YdcF-family-protein	unknown	unknown	gnl\|CDD\|99750
NC_015690.1\|WP_014370090.1\|3019362_3019848_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377263
NC_015690.1\|WP_013916615.1\|3028165_3029884_+\|DNA-mismatch-repair-endonuclease-MutL	unknown	unknown	gnl\|CDD\|234630
NC_015690.1\|WP_013916606.1\|3015283_3015496_+\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013916619.1\|3032043_3034779_+\|PBP1A-family-penicillin-binding-protein	unknown	unknown	gnl\|CDD\|273955
NC_015690.1\|WP_013916621.1\|3035763_3036474_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|224561
NC_015690.1\|WP_013916617.1\|3030654_3031620_+\|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	unknown	unknown	gnl\|CDD\|234626
NC_015690.1\|WP_013916607.1\|3015682_3016705_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|223787
NC_015690.1\|WP_013916611.1\|3021093_3021654_+\|outer-spore-coat-protein-CotE	unknown	unknown	gnl\|CDD\|371168
NC_015690.1\|WP_013916616.1\|3029884_3030658_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|377360

Protein	Function_ID	Function_description	E-value
NC_015690.1\|WP_013916618.1\|3031644_3031887_+\|RNA-chaperone-Hfq	gnl\|CDD\|379947	pfam17209, Hfq, Hfq protein.	4.39731e-40
NC_015690.1\|WP_013916610.1\|3020022_3020988_+\|membrane-protein	gnl\|CDD\|378698	pfam11728, ArAE_1_C, Putative aromatic acid exporter C-terminal domain. This region is a presumed intracellular domain found in a set of bacterial presumed transporter proteins. The region is about 160 amino acids in length.	5.56489e-52
NC_015690.1\|WP_013916613.1\|3023509_3026287_+\|DNA-mismatch-repair-protein-MutS	gnl\|CDD\|235444	PRK05399, PRK05399, DNA mismatch repair protein MutS; Provisional.	0
NC_015690.1\|WP_013916622.1\|3036506_3036902_+\|VOC-family-protein	gnl\|CDD\|319908	cd07244, FosA, fosfomycin resistant protein subfamily FosA. This subfamily family contains FosA, a fosfomycin resistant protein. FosA is a Mn(II) and K(+)-dependent glutathione transferase. Fosfomycin inhibits the enzyme UDP-N-acetylglucosamine-3-enolpyruvyltransferase (MurA), which catalyzes the first committed step in bacterial cell wall biosynthesis. FosA, catalyzes the addition of glutathione to the antibiotic fosfomycin, (1R,2S)-epoxypropylphosphonic acid, making it inactive. FosA is a Mn(II) dependent enzyme. It is evolutionarily related to glyoxalase I and type I extradiol dioxygenases.	1.38854e-33
NC_015690.1\|WP_013916614.1\|3026604_3028068_+\|PDZ-domain-containing-protein	gnl\|CDD\|223864	COG0793, Prc, Periplasmic protease [Cell envelope biogenesis, outer membrane].	6.17384e-91
NC_015690.1\|WP_013916609.1\|3017602_3018451_+\|ABC-transporter-permease	gnl\|CDD\|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	9.91921e-61
NC_015690.1\|WP_013916612.1\|3021829_3023308_+\|hypothetical-protein	gnl\|CDD\|373045	pfam14395, COOH-NH2_lig, Phage phiEco32-like COOH.NH2 ligase-type 2. A family of COOH-NH2 ligases/GCS superfamily found in the neighborhood of YheC/D-like ATP-grasp and the CotE family of proteins in the firmicutes. Contextual analysis suggests that it might be involved in cell wall modification and spore coat biosynthesis.	1.62369e-132
NC_015690.1\|WP_014370096.1\|3034927_3035626_+\|peptidylprolyl-isomerase	gnl\|CDD\|238194	cd00317, cyclophilin, cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug cyclosporin (CsA). Immunosuppression in vertebrates is believed to be the result of the cyclophilin A-cyclosporin protein drug complex binding to and inhibiting the protein-phosphatase calcineurin. PPIase is an enzyme which accelerates protein folding by catalyzing the cis-trans isomerization of the peptide bonds preceding proline residues. Cyclophilins are a diverse family in terms of function and have been implicated in protein folding processes which depend on catalytic /chaperone-like activities. This group contains human cyclophilin 40, a co-chaperone of the hsp90 chaperone system; human cyclophilin A, a chaperone in the HIV-1 infectious process and; human cyclophilin H, a component of the U4/U6 snRNP, whose isomerization or chaperoning activities may play a role in RNA splicing. .	7.08953e-62
NC_015690.1\|WP_013916608.1\|3016815_3017610_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213260	cd03293, ABC_NrtD_SsuB_transporters, ATP-binding cassette domain of the nitrate and sulfonate transporters. NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	2.98342e-108
NC_015690.1\|WP_013916623.1\|3036892_3037564_+\|YdcF-family-protein	gnl\|CDD\|99750	cd06259, YdcF-like, YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been idenitified. The family also includes Escherichia coli sanA and Salmonella typhimurium sfiX, which are involved in vancomycin resistance; sfiX may also be involved in murein synthesis.	7.8465e-45
NC_015690.1\|WP_014370090.1\|3019362_3019848_+\|hypothetical-protein	gnl\|CDD\|377263	pfam04246, RseC_MucC, Positive regulator of sigma(E), RseC/MucC. This bacterial family of integral membrane proteins represents a positive regulator of the sigma(E) transcription factor, namely RseC/MucC. The sigma(E) transcription factor is up-regulated by cell envelope protein misfolding, and regulates the expression of genes that are collectively termed ECF (devoted to Extra-Cellular Functions). In Pseudomonas aeruginosa, de-repression of sigma(E) is associated with the alginate-overproducing phenotype characteristic of chronic respiratory tract colonisation in cystic fibrosis patients. The mechanism by which RseC/MucC positively regulates the sigma(E) transcription factor is unknown. RseC is also thought to have a role in thiamine biosynthesis in Salmonella typhimurium. In addition, this family also includes an N-terminal part of RnfF, a Rhodobacter capsulatus protein, of unknown function, that is essential for nitrogen fixation. This protein also contains an ApbE domain pfam02424, which is itself involved in thiamine biosynthesis.	0.00677132
NC_015690.1\|WP_013916616.1\|3029884_3030658_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|377360	pfam04445, SAM_MT, Putative SAM-dependent methyltransferase. This is a family of putative SAM-dependent methyltransferases.	1.68722e-09
NC_015690.1\|WP_013916619.1\|3032043_3034779_+\|PBP1A-family-penicillin-binding-protein	gnl\|CDD\|273955	TIGR02074, Includes:_Penicillin-insensitive_transglycosylase, penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	0
NC_015690.1\|WP_013916621.1\|3035763_3036474_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|224561	COG1647, COG1647, Esterase/lipase [General function prediction only].	1.64016e-45
NC_015690.1\|WP_013916617.1\|3030654_3031620_+\|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	gnl\|CDD\|234626	PRK00091, miaA, tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed.	1.80471e-157
NC_015690.1\|WP_013916607.1\|3015682_3016705_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|223787	COG0715, TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism].	7.24301e-44
NC_015690.1\|WP_013916615.1\|3028165_3029884_+\|DNA-mismatch-repair-endonuclease-MutL	gnl\|CDD\|234630	PRK00095, mutL, DNA mismatch repair endonuclease MutL.	0
NC_015690.1\|WP_013916611.1\|3021093_3021654_+\|outer-spore-coat-protein-CotE	gnl\|CDD\|371168	pfam10628, CotE, Outer spore coat protein E (CotE). CotE is a morphogenic protein that is required for the assembly of the outer coat of the endospore and spore resistance to lysozyme. CotE also regulates the expression of cotA, cotB, cotC and other genes encoding spore outer coat proteins. The timing of cotE expression has been shown in Bacillus subtilis to affect spore coat morphology but not lysozyme resistance.	8.05431e-81

>NC_015690.1|WP_013916613.1|3023509_3026287_+|DNA-mismatch-repair-protein-MutS
MAKYTPMIEQYLAVKAEVPDAFLFFRLGDFYEMFFEDAVNAARELEITLTGREGGGERIPMCGVPYHSAENYIARLIEKGFKVAICEQVEDPAEAKGVVRREIVRIVTPGTVMDARSLSETANNYIVSVTAAGGGYALAACDISTGEFYVTRTDGSFELLLDELNAYSPSELLGAGALLERIRGAAAAWLTTSVLTPREHRPVNGGLSPEGHFSESQLAALPQGGREAVALLMGYLQETQKRSLGHIKHIRIYEPSQYMVMDPFTRRNLELVETVRDRSKKGTLLWLLDKTVTAMGGRLLRRWIEKPLMNAAAIESRLEAVERLYHQLILRDELKGALREVYDLERLTARIAYGSANARDLAALKLSLQQVPQLRELLAGSGSPALGELGERMDPCSDVMQLIHDAIVDEPPVSIRDGGMIRPGLSPRLDELREAGTNGKQWLAELERQERERTGIRSLKIGYNKVFGYFIEISKANLGSLEEGRYERKQTLANAERFVTPELKEKEALILEAQEGMVDLEYGLFLELRDKVAAHIPRLQALAELIATADVFQSIAQVSAANRYVRPEVGDFYPLEIEEGRHPVVEAVLEDGVFIMNDTVLSKEQGSTMLITGPNMAGKSTYMRQVAMICLMAQIGCFVPAKRAKVPVTDRIFTRIGAADDLIGGQSTFMVEMMDIQVMTEKATPKSLVIIDELGRGTSTGEGMAIAQAVIEYLHDRIGCKTLVSTHFHELAHLEESLKDLRNYCMAVKESGQQVTFLRKLVRGAASTSYGIYCAQIAGLPESIIGRSYELLHVFEERSEGLQERIQSAPETRPAADEGTAVPVGSAGAETLAAAAAETAAGADPAAAEHAPPAAVTVMEAPAAPAYAPQGIEQLSLFAVEEKPSRSAKKDPKQEKVLEQLRTLDLMNMTPMSAMNFLYELKKLV
>NC_015690.1|WP_013916612.1|3021829_3023308_+|hypothetical-protein
MRAFLLHSGEEKLRPLLERLTIAHGTRLEPAEEGGHFIIHWGAYHPDRGSADVLQPVKAVLLAGSSVRAGETLALHGMDSALGEEEAAGGRSRRGKQRGGAAEDEGWTHDFLVPVFHLEALTLLHRGPGVFYGGRVPAGVRLPEGLPDRGYEEVGLEQPTYYGSKALREAVKALYALGLDYGVVRIGVRTGGTLAVRRVEAVPELTPRLAELFAGAMNRYGARLDERRGAPQLDVMLGADPEFLLLNGRGKVRFASAFMDKDGPVGCDAIVLPSRRKIYPLAELRPRPSTEVRELIVQLHRTLQLAARRITDEELVWVAGGMPVKGFPLGGHIHFSRVDLESRLLRVLDNYLALPLTLIEDGSTGQRRPQYGFLGDFRRQRHGGFEYRVLPSWMVSPAVAKGVLALAKLAAEHYPQLRQRPLSDPEVAKAYYRGDKSRIRPLLPALWRDLERLPGYAALEDYLLPLRRMMVQMRPWNEREDIRTKWKIRPYS
>NC_015690.1|WP_013916611.1|3021093_3021654_+|outer-spore-coat-protein-CotE
MSLDKDLQCREIYTKAVCGKGRKFSQVTNTVTPPHAPTSILGAWIINNQYDAVKSGENVEVVGTYDINIWYSYDRNTKTDVAKETVSYAEVVPLHYLDKKHKPGTAEVSAVATQEPNCVEASISSSGSSVVLRVEREYKVEMLAETKVCVVVCGSCDDYDDKHVEFGGDDGDYEDLDPDLLDEELN
>NC_015690.1|WP_013916610.1|3020022_3020988_+|membrane-protein
MGIRVLKSALAVIAAIYLSLAVGLTSPLSAGLLAIMGVDVTIRKGLSTSFQRIAASVIGLFFASGLFWALGFHVWVIGVFVLVLYPVLAQLQLRDGIITCSVVMFHVYGAGALSTDLLLNEIALLVIGLGTATVINMLYMPREHKNLQHYRLKVEELFSRIFVEISRHLRDNEYVWSGAELLQAEDTLRDAIRTAERTEQNSIVSGGPAWSVYFHMRDRQLLSISRMAQLVARVYQTLPHGELLAAVFDELKEDVKVAHYTGRGEKRLEELQEQYRLMPLPVTREEFEIRAALLQLVEELKAYLAVAKREKRPMEKSSGGA
>NC_015690.1|WP_014370090.1|3019362_3019848_+|hypothetical-protein
MYIFATFELCIHTELLLTALEMEGVPRQRVMAVPLDQRREPGALFDSLHKADGFAMMDASAILGTCLMLLGSIYGYMLAWGPIIWGIIGALTGIAIGFGLKWLYLRRIGFGTRNITSEVVLLIDCPEQKCETVEKLLWEHMALGVAKLAQEKPESNAADKR
>NC_015690.1|WP_016362588.1|3018579_3019356_+|hypothetical-protein
MNRTPTYRRYRALLSPFNTSQIHRKNPWISAFFSFSFPGFGNLLQHRYAKGFTLISWEIFINSHAKINTGIMYSLQGHFAKAKETLNPNWLMIYVSIYMFGIWDSYRSTVELNKLYTLADREDAPIKPMAMSVWDINFLNKRVPWVAAAWSLLAPGLGHLYLHKVLPGFFLFGWTIAIMYFSHIPMAMLYTASGDFRQAKEVLDMQWTLYLPSIYCFVFYDAYVSAVEYNKLFEKEQSKHLRTNYQDPGFRMPRSQEG
>NC_015690.1|WP_013916609.1|3017602_3018451_+|ABC-transporter-permease
MAELKGTPAEEGRQQPAELADEVYTAFRRSERRLALSVRLTQLALLVLFFGLWETAAAFKWIDGLLFSSPSRIVQLLYEKLLDGSLLEHTWVTVWETVVGFVLGTLLGTAGAALIWFSPFLSRVLDPYIVVLNSLPKVALGPLFIVALGPGVLSIIATTLSLTVIITILVIYNAFREVDPNLVKVVRIFGGSTGTVFRKVILPASYPAIISTLKVNVGLAWVGVIVGEFLVSKAGLGYLIIYGFQVFNFTLVIGALFVIAAAAALMYQLVASVESRLIGRSR
>NC_015690.1|WP_013916608.1|3016815_3017610_+|ABC-transporter-ATP-binding-protein
MESAVELDHVSHVYVNGRGAYPALLDISLTVRQGEFISLIGPSGCGKTTLLSLISGLLTPTAGNIRVFGEKVEQGGVQRIGYMLQQDYLFPWRTIGANASLGLELLGRLDAASQKLVDGLMEEMGLGGQSQRYPHQLSGGMRQRVALVRTLATEPDVLLLDEPFSALDYQTKLQLEELVSGTLKARGKTAVLVTHDITEAVAMSDRVIVLQPNPGRLLADMEVPELIRAASPLKARETEGFHELFHRLWGLFESMDKGGGRSHG
>NC_015690.1|WP_013916607.1|3015682_3016705_+|ABC-transporter-substrate-binding-protein
MNKRWKQGAAAVLALGLGLAAVLSGCGPAKTEESVKVRIGEVTRSIFYAPQYVAVNQGFFKAEGLDVELTTTFGGDKTMTALLTGGIDVALVGSETSIYVAQQGSGDPVINFAQLTQTDGTFLVSRKPAQGTFDWNSLKGSTFLGQRKGGMPQMAGEFTLKKHGINPQKDLNLIQNVEFANIPTAFASGTGDYVQLFEPQATMFEQQGKGYVIASFGVESGRLPYTVFMTKKSYIDKNPDALQKFTNAVQKAQNWVAASSVDVIADSIASFFPDTDKEIIKGVVKRYKDQGSFASDGIVDAEEWSNLQNVMEAAGELKARVDHGSLVDNRFAEKAKASVK
>NC_015690.1|WP_013916606.1|3015283_3015496_+|hypothetical-protein
MRHLLPFILFTAVLAVDLRRLKRGGKRGAAVYLAFLGGAFLLSELYLFHLEPPSPNRIISQLVRLLIPAA
>NC_015690.1|WP_013916614.1|3026604_3028068_+|PDZ-domain-containing-protein
MKRKKSMNMWRRSAAAVLSMTLLLPAAQPLQAAGTGSSGASRVQEVMELLQKKHVSAPSADALSDAAVKAMVESLEDPYTQYFTPEELQQFEDAVENQYVGIGVRIGLEPEGVYIADVFEGSPAKEAGLAPGDLIVTVGGTSVAGKKTGEVAELIAGEPGTTVVVGVVRGSETKEFTVSRKKVQIPTVVSRVFPSKVGYLEIASFSSDADELLEKELAALKSQGIRSLILDLRDNPGGLLESAKGMIRQFVKEGTLIHTLDSSRVDKPVEFSGGTTQPFPLYVLVNENSASASEVLTGALQDYGAAKVIGAHTYGKGSVQSVYELEGGGALKVTIEEYLTPKNRKVNHVGLDPDVAVEGYLAQLLTALRLAGEKEPVLTADPRITTVGGLMVQDTLDVVREGGQTYVPARALAAYLGGTVQWNEASRSVVLVSADGTTMYTPGEGGFLLKEGTGFVSLNGVSKDAFGSSLQWIDDGRKLTIRTGASK
>NC_015690.1|WP_013916615.1|3028165_3029884_+|DNA-mismatch-repair-endonuclease-MutL
MGKITILDEHIANQIAAGEVVERPSSVVKELVENAVDAGSTRVDVSIEEGGLQLIRVTDNGGGIEEDDVEAAFFRHATSKIATSQDLFSIRTLGFRGEALPSIAAVSKVECLTSAGSTGLGTRLRIEGGTVRLKEDAAAQRGTDLSVRELFYNTPARLKYMKTVQTELGHVTDYMYRLALAYPNIAFTLKHNGHVLLQTLGSGDLLQAVAAVYGSSLAKSMLKIEGETLDYKLEGLISKPELTRANRGGITTVINGRYIRSFPVNQALLQGYHTLLPIGRFPVAVLHLTMDPTLVDVNVHPAKLEVRFSKEPELIALIPQGGAPAAPARVREQLVQEQLELYRPQAASAADARETAAASGALLRALAQTEASAPPALPAFPKLTPIGQLHGTYIVAQNEEGLFLVDQHAAHERINYEHYFDLFGRPAEASQELLVPMTLEYTSVEALRLTEKLPQLEQAGVYLEPFGGTSFLVRAYPHWLPKGEEQAIVEEMIDLLLQDKKGIDIAKFREKAAIMCSCKASIKANQSMGTLEIEVLLDRLAACRNPYTCPHGRPIVVSFSTYELEKMFKRVM
>NC_015690.1|WP_013916616.1|3029884_3030658_+|class-I-SAM-dependent-methyltransferase
MFVTTSYDPNPAQREEARRLAAELGGRAVDRRRMTLAQLRARYGDEDILLISKERIEYHHELRQPLFFHPSTAAVRIKRLIKGEPDSLLELAGVRPGDRIVDCTAGLGSDSLVFSYAAGPEGHVTALESAPIPCFLLKQGLKTYHSDVPGLNESMRRIEVLGADHLTYLRGLPPKSVDLVYFDPMFRKPITESNSIRAIRGLADDRALSEEAVGLALSAARRAVVLKEHRDSAEFDRLGFAEVHRSSTKIAYGVIRT
>NC_015690.1|WP_013916617.1|3030654_3031620_+|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA
MTPSPERKPKLLVLVGPTAVGKTKLSLTLAKEYNAEIISGDSMQVYRGMDIGTAKASPEELAEVPHHMIDIHDPDHPFSVAEFQERSRALIEEISGRGRLPFIVGGTGLYVESVCYDFKFSESGSDEAFREEQQAYADTYGPEALHERLRAVDPASADRLHPNDVRRVIRALEIYHVTGERQSEQLEAQGRKESPYELCIVGLTMDRALLYKRIEERIDIMMRQGLLEEVRGLMERGYDEAVVSMQALGYKEIVGHLQGHYSLEEAVELLKRDTRRFAKRQLSWFRHMKDIAWVDVSNLAEFATHLDKIRGIISAKLTLDR
>NC_015690.1|WP_013916618.1|3031644_3031887_+|RNA-chaperone-Hfq
MNKSINIQDTFLNQLRKENIPVTVYLTNGFQIRGVIRAFDNFTIIIDSEGRQQMVYKHAISTFTPQRSVSLMQQTENTAE
>NC_015690.1|WP_013916619.1|3032043_3034779_+|PBP1A-family-penicillin-binding-protein
MADSGSKTPRKTTVEKKPAAGAAKKKKKQGFSAGKVIFWMLAAAALAAISAMGVYIFVILNGNKILQQNIDKLDFSEASIIYDANKQEIGVLKVENRINVEPNEIPPLMKQAFIATEDKRFEDHTGVDFLGIGRALVKDVVARSMVEGGSTITQQLAKNVFLNADKTFFRKATEMSIAVALEQQKTKDEILTMYLNYILFGNQAYGVKAASKVYFNVDKLEDLKLWQIATLAAIPKAPSRYNPLKDAEKSKERRGVVLKLMQEQGYITEAQRAEAAAVDYEPPTKTAGTAGRNQAFVDYVLKEAQTNFNLTEDEVNRGGLKIYTTLDQNAQQIMEQTYANAKFFQKSPDDQIMQSSMVILDNKDGGIVAMVGGRDYMRGGLNRATSAPRQPGSSFKPLIAYAPAIEAGKYTPYSMLKDEKQTYPGGYSPRNYDGVYRGQVTMTEAVKKSINMPAINTLQEIGVSNATKFVEKLGITLDAQDRNLAIALGGLTKGTTPLQMAQAYSAFANAGTLHTAHAITSIVESDGTELQFKDEAKTVMSAKTAWYMTEMMRTVVEPGGTGAAAKFERPVAGKTGSTQLDLKGLEKYNRDLWFVGYTPEWTGAVWMGFDKTDSKHYVSMSSGSAGVIFKEVMQKALAKRPVTQFKKPSGVPDLKEELPPKGVTDLKAEVNPETGFVNLSWSSVGDGITYQAFRKDSTMADYPAEPLFSTQSTSYKDQSAYTPGMTYTYMIVALKPENGAEGAKSNEASVTIPGKTENGKEEPGKEAGETGKEDPGKEGEDGAVPGTDGDGTAQPGTGTKPGAGGTTQPGTTKPGTSKPGTGTTPGTETDGTTGGTEEDAGSAGGSGDTGTSSGTDTGGETGTKTPGSTTTRPSTGTAPVPSGTSGNGKQPAERSTGGQSGSSISVMPDGT
>NC_015690.1|WP_014370096.1|3034927_3035626_+|peptidylprolyl-isomerase
MNAKQVSGIAKVLCTAALAALLAAGCGTKPAENTQGAAGGSQATAGTDTAKEGTTRKTYTSAPPMTIDATKKYTAAVTTSKGSFTIELFAKEAPKTVNNFVFLAREGFYNDITFHRIIQSFMVQTGDPLGNGMGGPGYKFEDELKSPYKYEPGIVAMANSGKNTNGSQFFICTGEDSKGLNSQPNYTIFGRVVEGMDTVQKIAATPVAAGGESKPSKPTEKVTIMKIDITEK
>NC_015690.1|WP_013916621.1|3035763_3036474_+|alpha/beta-fold-hydrolase
MEQGSGISHRQRRCLLIHGFTGGPYEVQPLADYLAGCGCECHVLRLPGHDDELSGLRSVVWQEWLQGAEEEMARLTGDGEPVDLIGFSMGGLISAYLANRYPVRRLVLLNAAAIYVSPVRFLKDVALRARQKDWDYLKRGKKTPLRAAVQFMKLARYAKREELPKVAVPTLIAQGRRDQIVHPRSADYIYRRLQGERELHFFERSRHLICLEEDAPALFAEVRRFLGVEGEDRDVT
>NC_015690.1|WP_013916622.1|3036506_3036902_+|VOC-family-protein
MQVKGFNHLTIRVRDLSRSLAFYEGVLGMKRVHRGRTDAYLEWGSAWICLLEREPDGEGSTGGRTGIDHAAFTIEEGDFPKAVETLRQAGVRLVRGPVERGGGFSVNFLDPDGTELELFTGSLQERMKTWS
>NC_015690.1|WP_013916623.1|3036892_3037564_+|YdcF-family-protein
MELRQAAAGRYRKKTRVSLLGHLKRIFRFMVLVLLAALLWVGWIQYRIETQADTGQEPKQVGIVLGASLWKDSPSPALKERLDRAVELYQSGRVPYLIVSGGYDVPTSKMTEAEGMRNYLVSKGIPSKRIVLENRARSTYENLLYSKKIMEQHQWTSAVIITHRYHSVRALDIANYLDYEEPAVSPMESRVLMMAWHRGRETLAMTKWQWDKVALVFGVAPKS

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Crispr_ID: NC_015690_17

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015690_17

3117883-3118071

Orphan

Consensus_repeat	Method
AAATAGCGGAACTCAGGTACGCTAT	CRISPRCasFinder

3 spacers

WYL,csa3

The CRISPR arrays of NC_015690_17

>merge|NC_015690|17|3117883-3118071|CRISPRCasFinder
GAATAGCTGAACTGAAGTGTGCTGTCGGGCTGATGTGAAGCGCGATATTCGAAATAGCGGAACTCAGGTACGCTATCGTGCTAATGCGCGAGGTGATAATCCAAATAGCGGAACTCAGGTTCGCTATTCGTGCCGAGCAGGGGGGCTGGCGGTGAATGCCGGGCCAATAAGGCATCTGAGTTCCGCTAT

>NC_015690|17|11|3117883-3118071|CRISPRCasFinder
GAATAGCTGAACTGAAGTGTGCTGT	CGGGCTGATGTGAAGCGCGATATTCG
AAATAGCGGAACTCAGGTACGCTAT	CGTGCTAATGCGCGAGGTGATAATCC
AAATAGCGGAACTCAGGTTCGCTAT	TCGTGCCGAGCAGGGGGGCTGGCGGTGAATGCCGGGC
CAATAAGGCATCTGAGTTCCGCTAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_015690.1\|WP_013916702.1\|3110072_3110900_+\|esterase-family-protein	unknown	unknown	gnl\|CDD\|223700
NC_015690.1\|WP_013916704.1\|3116421_3117324_+\|TIGR01777-family-protein	unknown	unknown	gnl\|CDD\|187553
NC_015690.1\|WP_013916711.1\|3123637_3124579_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381308
NC_015690.1\|WP_041616901.1\|3126799_3127312_-\|GyrI-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|214874
NC_015690.1\|WP_013916709.1\|3121900_3122902_+\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NC_015690.1\|WP_013916705.1\|3117334_3117652_+\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013916698.1\|3108367_3108802_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377503
NC_015690.1\|WP_041616902.1\|3127522_3128536_-\|NAD(P)-dependent-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|176237
NC_015690.1\|WP_013916695.1\|3106976_3107765_+\|TIGR00266-family-protein	unknown	unknown	gnl\|CDD\|376704
NC_015690.1\|WP_013916714.1\|3125837_3126860_+\|YafY-family-transcriptional-regulator	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|225253
NC_015690.1\|WP_013916700.1\|3109125_3109635_+\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|378975
NC_015690.1\|WP_013916694.1\|3105688_3106867_+\|formate-dependent-phosphoribosylglycinamide-formyltransferase	unknown	unknown	gnl\|CDD\|236454
NC_015690.1\|WP_013916696.1\|3107845_3108121_+\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013916716.1\|3128674_3129076_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
NC_015690.1\|WP_013916717.1\|3129271_3130066_+\|helix-turn-helix-domain-containing-protein	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|176902
NC_015690.1\|WP_041616898.1\|3118723_3120847_-\|DNA-topoisomerase-III	unknown	unknown	gnl\|CDD\|236078
NC_015690.1\|WP_081473179.1\|3125205_3125583_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|366361
NC_015690.1\|WP_013916701.1\|3109697_3110039_+\|bacillithiol-system-redox-active-protein-YtxJ	unknown	unknown	gnl\|CDD\|378538
NC_015690.1\|WP_013916708.1\|3120937_3121777_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|197666
NC_015690.1\|WP_013916703.1\|3111053_3116216_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|226415

Protein	Function_ID	Function_description	E-value
NC_015690.1\|WP_013916702.1\|3110072_3110900_+\|esterase-family-protein	gnl\|CDD\|223700	COG0627, COG0627, Predicted esterase [General function prediction only].	1.20812e-38
NC_015690.1\|WP_013916704.1\|3116421_3117324_+\|TIGR01777-family-protein	gnl\|CDD\|187553	cd05242, SDR_a8, atypical (a) SDRs, subgroup 8. This subgroup contains atypical SDRs of unknown function. Proteins in this subgroup have a glycine-rich NAD(P)-binding motif consensus that resembles that of the extended SDRs, (GXXGXXG or GGXGXXG), but lacks the characteristic active site residues of the SDRs. A Cys often replaces the usual Lys of the YXXXK active site motif, while the upstream Ser is generally present and Arg replaces the usual Asn. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	4.10246e-123
NC_015690.1\|WP_013916711.1\|3123637_3124579_+\|aldo/keto-reductase	gnl\|CDD\|381308	cd19082, AKR_AKR10A1_2, AKR10A family of aldo-keto reductase (AKR). Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.	9.65773e-153
NC_015690.1\|WP_013916709.1\|3121900_3122902_+\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	1.76656e-81
NC_015690.1\|WP_013916698.1\|3108367_3108802_+\|hypothetical-protein	gnl\|CDD\|377503	pfam05360, YiaAB, yiaA/B two helix domain. This domain consists of two transmembrane helices and a conserved linking section.	1.64753e-14
NC_015690.1\|WP_041616902.1\|3127522_3128536_-\|NAD(P)-dependent-alcohol-dehydrogenase	gnl\|CDD\|176237	cd08276, MDR7, Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family. This group is a member of the medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, but lacks the zinc-binding sites of the zinc-dependent alcohol dehydrogenases. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P)-binding Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	8.14278e-178
NC_015690.1\|WP_013916695.1\|3106976_3107765_+\|TIGR00266-family-protein	gnl\|CDD\|376704	pfam01987, AIM24, Mitochondrial biogenesis AIM24. In eukaryotes, this domain is involved in mitochondrial biogenesis. Its function in prokaryotes in unknown.	4.78703e-85
NC_015690.1\|WP_013916714.1\|3125837_3126860_+\|YafY-family-transcriptional-regulator	gnl\|CDD\|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	7.29277e-62
NC_015690.1\|WP_013916700.1\|3109125_3109635_+\|metallophosphoesterase	gnl\|CDD\|378975	pfam12850, Metallophos_2, Calcineurin-like phosphoesterase superfamily domain. Members of this family are part of the Calcineurin-like phosphoesterase superfamily.	1.69343e-37
NC_015690.1\|WP_013916694.1\|3105688_3106867_+\|formate-dependent-phosphoribosylglycinamide-formyltransferase	gnl\|CDD\|236454	PRK09288, purT, formate-dependent phosphoribosylglycinamide formyltransferase.	0
NC_015690.1\|WP_013916701.1\|3109697_3110039_+\|bacillithiol-system-redox-active-protein-YtxJ	gnl\|CDD\|378538	pfam11009, DUF2847, Protein of unknown function (DUF2847). Some members in this bacterial family of proteins with unknown function are annotated as YtxJ, a putative general stress protein. This cannot be confirmed.	1.59685e-48
NC_015690.1\|WP_013916716.1\|3128674_3129076_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	1.01621e-40
NC_015690.1\|WP_013916717.1\|3129271_3130066_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|176902	cd08893, SRPBCC_CalC_Aha1-like_GntR-HTH, Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain. SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. Some proteins in this subgroup contain an N-terminal winged helix-turn-helix DNA-binding domain found in the GntR family of proteins which include bacterial transcriptional regulators and their putative homologs from eukaryota and archaea.	5.98335e-17
NC_015690.1\|WP_041616898.1\|3118723_3120847_-\|DNA-topoisomerase-III	gnl\|CDD\|236078	PRK07726, PRK07726, DNA topoisomerase 3.	0
NC_015690.1\|WP_081473179.1\|3125205_3125583_+\|VOC-family-protein	gnl\|CDD\|366361	pfam00903, Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily.	2.21635e-09
NC_015690.1\|WP_041616901.1\|3126799_3127312_-\|GyrI-like-domain-containing-protein	gnl\|CDD\|214874	smart00871, AraC_E_bind, Bacterial transcription activator, effector binding domain. This domain is found in the probable effector binding domain of a number of different bacterial transcription activators.and is also present in some DNA gyrase inhibitors. The absence of a HTH motif in the DNA gyrase inhibitors is thought to indicate the fact that these do not bind DNA.	1.73287e-22
NC_015690.1\|WP_013916708.1\|3120937_3121777_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	1.61285e-25
NC_015690.1\|WP_013916703.1\|3111053_3116216_-\|AAA-family-ATPase	gnl\|CDD\|226415	COG3899, COG3899, Predicted ATPase [General function prediction only].	1.41531e-140

>NC_015690.1|WP_013916705.1|3117334_3117652_+|hypothetical-protein
MLIYGSTDIHELRFEELTARVERRDEQWIDVEVGFRVAGPDAVPEDITELGALLVVTYRGDIAEIAPQDEGRDCEYQFTESEKAQLREFYEREVRPQVLQAAGQE
>NC_015690.1|WP_013916704.1|3116421_3117324_+|TIGR01777-family-protein
MKVAIAGGTGFIGGHLTRYYAERGTEVVLISRSARASDKERVRYVTWSELEKDVSAVEGAEAVINLAGESINQRWSEAAKARILDSRLDSVRRVADIVGRLERKPVLVNASGMSVYGLSDTESFTEESPRRLDHFLAEVVEKWEAEIRRVPAARTVMLRVGVVLGRDGGAYPKMRLPFVFGAGGRIGSGRQWLSWIHVDDIIRLIDYCVTQEEMAGPVNATAPEPVTNDAFGRALAKVMGRPYLFPVPGLVMKLIFGEMSMLLLEGQKVLPQAALSGGFRFTYPTIEEALRSLERRAKGG
>NC_015690.1|WP_013916703.1|3111053_3116216_-|AAA-family-ATPase
MALQLNEGAAERLDDTAAATWFRTEDSGGRRRLVKALKAEYGTPGEVQRLRLELEKGRRLGFPEVLLPLGIVTFRGTPALVTEAAEGVLLSSVLSPVPAAPEVFLPLALSMTDAVRQLHKHKFAHTALSHQAFFIDKDAAGGRVRLTELHSLVSLGSPHDPAAPAESAVPPQPERNPFLAPEQMHDPAAGRVNVRPDHRTDLYALGVLFYRLLTGLFPSLPDIGSDGSAPSPVPPAELAVSVPEVLSAVVMKLLARQPDQRYPSAFALHRDLAKCLEQWSAAGTIEAFALGTVAGSDHFAISETIYGRETELEQLHAAYGRCLSGSLQTAFVSGLSGIGKSYLIHEFQKGLTPGSALYVHGKFDQYKRESPYYAIRQIGRQLMQHLLQQPPEELQLLKERIRDAVGPNGQILLEMNPDLEAVIGKQPPLTKLPPAEMHNRFILTIRQYTSVFASQEHPLVLFLDDLQWADPASLQLVSEFLLEMPFPYLLFIGAYREREVTDSHPLRSLIGKLGRSRTAPVEIRLEPLQEPHVARLLEDTLQPSKQDPRELAGLIMSKTKGNPFFTKQFFRSLYDQHLLRFDDRSCCWAWDTDRIKELHITDNVVDFMISKIRRLSESMQHLLMHAACLGQQFTPEVLSLVTGYDGDRTALLLKQAVDDSLLLRVVGGRRTSSAEAVTSYKFMHDRVYQAVYSLLPDSDKKRIHLHIGRLLQAYYAEEEHDLTVFEVTDQLNLGSDGITSPPEREDLAELNLRAARKAKGNSAFDTAYRYASQGVQLLGEEAWSSRFELAYALRLEMAELEYLCGHFGEAKASFETVLRLSRTKLEKADVYNLMIILHTHIGEHEQAVRLGLEGLKLFGLSLRPKIGKGSILWEMFKSRIHLGLRSQDDLLDHYPMSEPEHEAVMRFLVNLIPSAYFLDADLYVYLMLRMFNYSLMHGHSDGSAYAYSTYGVILSAVFGRLKAGWEYGRLSVQLSDIYPNPAIKSKVYFAYGGFSNNIREHIEANVGHLRKAYQYGVESGDLVYAGYSIAFSFFMQVLKGDTLPEILQESEKYRQFVHQAQDRDVIWIYTVIQRYILSLKETAGAPNAPQEPLLSPEEAQIVRGLSNKAVVHTFYGLQAQSFYLLNHLEEARLICEETEANLGQMFGFPHIELHHFQYGMVLASLYDHAGNALQMKYRKRIRKSLKILGKWAAHSPSNYLHMNLLLQAEYDRITDKRMQAAEKFDLAIQAAARSGFLPREALANERAALFYLRTGRIKIAKAYLLDARSLYERWGAARKVAQLEALYPGLLGWASSADVLPAACGVLKATPPVTYQTVFHHMLDCMMSQMLEYARADKALLMLEQDGQLQIEAEKSLKDPFRSLHSTPVEEGVPAAVTAVDYVKQSGEPLLLKEAPDAGLFGNDPYIREIRPQSLLCLPLTGRGEAAGILYLESRTAAHAFQPDRFGRLKLLAAAAAELVRRARLTASLEVKEDLLPQAHELGRQQSRPQPVVPESRRGTARDGTPSSLQLAQTQFIRRLQGVHALLALNKTETAQESIAVWCEELVQMTLADSVAFPALRSALLSLLPAITAAGIELQVDGRLDCLFERLSLPPSLFAGTLQPLLQHALDAAAARESQRVVRLTLTESESHYGLAVLYSGSPVGEEPRHRPFEKAPPLRAEDSPVVPLVQSLQHMLQPYGGELQCRYEAGRGMIFTLRLPKQAAGDRVPREAAASGLDH
>NC_015690.1|WP_013916702.1|3110072_3110900_+|esterase-family-protein
MAVQSFSFFSGALYARKVCQVYLPPSYDASEDTRYPVIYLLHGLNGDETSWLVKGGAEAQLDRLMGDGTLRESIVVMPSDGGYGHGTFYVNWYDGTGRFEDYFLYDLMPSIDREFRTIADRSSRALCGLSMGGYGAFVLALRNPELFGAAASIAGALMSTGLMTEQFLRSEVSRLVGPVHGPFARELDLHVLAARRLREEQRPELHFNCGFSDYLYPLNSAFKALLDQLNYPHDYAEYEGEHNWDYFGGHLAEALAFIERSFAGAPAGEAPAEIG
>NC_015690.1|WP_013916701.1|3109697_3110039_+|bacillithiol-system-redox-active-protein-YtxJ
MSKWKEITTKEEWEQYYEGSGSKPFVVLKHSTACPVSFNALQEYEAYLGKTPNEQVDYILVKVIESRPVSNQIAEETGVKHASPQVLYIKNKETVWNTSHWSITEEHLTAVLN
>NC_015690.1|WP_013916700.1|3109125_3109635_+|metallophosphoesterase
MRIGVVSDTHMFGRGAALPAALVRGLQGTDLILHAGDWMDERVIALFEAIAPVDGVAGNNDGPEIIRRFGRRKVLELAGYRIGLVHGDGGRSTPETAYAAFRTKEGEVLADVVIFGHSHTPFHEVRGGQLLFNPGSPTDKRRQPLYSYGILTLGESVSAELFTYEDKSP
>NC_015690.1|WP_013916698.1|3108367_3108802_+|hypothetical-protein
MRKRNTSAFTFLAWTSFASALLAMFIGITTLEETLSVKGYYAVSALYLTMASFVLQKTVRDNQEDGAQARRRNTGAFTFLSWTAFSTALLAMFIGIVNLEQPLSVQGYYAVTALFLTMSSFVLQKTVRDNKEDSEMYAEPDTHE
>NC_015690.1|WP_013916696.1|3107845_3108121_+|hypothetical-protein
MAYNPQVTDAKVVSYNPKNGLFEIVANLKDRTVCRLTYESDETGGAKATHISRLLQEPCPICRKDFLCNCMDKFKENIAGQALEHTGVPTA
>NC_015690.1|WP_013916695.1|3106976_3107765_+|TIGR00266-family-protein
MNAHEIDYAIHGSEMQYVEIELDPGESVIAEAGSLMMMDQSIHMETIFGDGSDQGKGLMGKLFGAGKRLLTGESLFMTIFTNRGHGKERASFASPYPGRILPMDLSMLGGKIICQKDSFLCAAKGVSVGIDFQRKLGAGFFGGEGFIMQKIEGDGLAFVHAGGAICERELRPGEMIRVDTGCLVAMTQGVDYDIEFVKGVKTALFGGEGLFFATLRGPGRVWIQSLPFSRLADRVLAAAGPGGRKEEGSILGGLGNLLDGDR
>NC_015690.1|WP_013916694.1|3105688_3106867_+|formate-dependent-phosphoribosylglycinamide-formyltransferase
MYGAPLSAGAHKIMLLGSGELGKEVIIEAQRLGVETVAVDRYANAPAMQVAHRSYVISMLDGEALRELIEKEKPDLIVPEIEAIATQTLVELESEGYRVIPTATAARLTMDREGIRRLASETLGLPTARYAFADTLDELKAAVAEIGTPCVIKPIMSSSGKGQSVCRTPDDIETSWNLAMEGGRAKKARVIVEEFIRFDSEITLLTVRSASGTSFCAPIGHIQKDGDYIESWQPHFMSAAQLEEAQEIAAKITDALGGTGLYGVELFLAPDKVYFSEVSPRPHDTGMVTMASQDLSEFALHVRAILGFPVPTIRLLTPAASYTLKADRDAETFRIGGLPEALALPNTQVRVFGKPETKPGRRMAVALSTGETVEEARRLAKEAAGNLRIEYS
>NC_015690.1|WP_041616898.1|3118723_3120847_-|DNA-topoisomerase-III
MKSLVLAEKPSVAKEIARVLGCQQKHKHYMEGPQYVVTWALGHLVTLAEPEEYDPKYKTWNLEDLPLLPSKMKLKVIRETTPQFKAISQLAQRGDLKELIIATDAGREGELVARWIMELVRWRKPYKRLWISSQTDKAIRDGFAQLKPGPAYDPLYRSAVCRAEADWLIGLNITRALTCKHNAQLAAGRVQTPTLAAMMDREAQIRSFQAKDFWMLRAQLGSFQALWRSQAHPDGRLFDKAAADTLLERLKTARSAKVSALKVSEKSEPHPLAYDLTELQRDANKRLGFTAKQTSNVLQRLYEQHKLVTYPRTDSRYLSSDMVSTLPDRLKALLGTPYGASAKGLLARPLPVTKRIVDDSKVSDHHAIIPTDERPQLQLLGADERRLYDLIVRRFLSLFFPAFRYDETAVTLDIAGESFHAKGRIVKDQGWKAVYDGSSAPSEADDDDAPEEEPSSLQSLPALQLGTELKDLRLSQQKGTTKPPGRYTEAGLLSVMEKQGLGTPATRADIIEKLLSTDTIERRMNTLQPTGKGVQLMELVVPELRSSELTASWERELERIAKGQGDPDAFMAGIRKQTEAIVRDVKNSSAEYKPHNLTHSKCPDCGSPLQDIKGKRGRMLVCSSRECNYKRAAEAQLSNKRCPQCRKKMEIHTGKAGKYAQCRPCNVIEMLNDTGGAGGRGKAGKRQQSQLAEQYSDNAKLPSALEE
>NC_015690.1|WP_013916708.1|3120937_3121777_-|helix-turn-helix-domain-containing-protein
MKRQSMLPTLNRTEFMILPESVGWYTEMPDHEVSRKAGVLNNFSIHIVLGGRGCVEHDRSVYTLQRGDAFLYFPLTEQRYYSSQDDPWEVRWVHFYGSGLREYLIERGFSRSPLWKLRQTKPVEDALDALLVEAEARGFLGLTRLSTLTYAVLAEFVSEAAPWSDPRSAEPGSRVLDLLPAMRAEACLPFDLQEWADRAGVSTYYFCRLFKKATSMTPMTFITLSRLQKGKQLLLEQPDLTVKDIAEQTGYPSVSYFNKRFLEQEGMTPTDYRQLYRKE
>NC_015690.1|WP_013916709.1|3121900_3122902_+|Gfo/Idh/MocA-family-oxidoreductase
MSEKKIRWGILGCANIAVRAVIPGTQKSETGVVAAIASRGIGKAQETAEKMGIPTAYGSYEELLADESIDAVYIPLPNHLHKEWTIKAAEAGKHVLCEKPAALNAEETREMAAACEKAGVIFAEAFMYRYHPRYQMIREIIASGEIGEVRGIHGAFTFNNAKDTGNVRYQQHMGGGSIYDVGVYPISAARFILGQEPEAATVHGFFSPEHDGVDMMASGLLEFPNSVALTFDCGMWAAGRNVLEILGTDGRIEVPSAFVTNGSERDHFIVHAKGESREVQVPYLNQYALQADAIGRSVLYGEPMPFGPQDAVNGMRVVDACLTSARERRRIEL
>NC_015690.1|WP_013916711.1|3123637_3124579_+|aldo/keto-reductase
MRTITIQGLDKPVSCLIKGSDYFREDVYEKAARNLDAYFAIGGNTIDTAYIYCGGESEKTIGRWMAERGNRDQVIILTKGAHHNKDGPRVNPEAIEADLQESLQRLGTDYVDLYALHRDDPSVPVGIIMDALNEHIQAGRIRAIGGSNWTTARLQEANEYAAQHGLVPFTFSSPNLSLAKANEPFWSGCVSADSSDCAWHEQHQLPLLSWSSQARGFFTGRFTPEVRDNADLVRVFYSDANWDRLRRAEQLAAERGVTAIQIALAYVLNQPFPACALIGAQTPEELESCRQGAEIVLTREELEWLEHGTPVRA
>NC_015690.1|WP_081473179.1|3125205_3125583_+|VOC-family-protein
MPIVNRVDTIFVHVTDLERSISWYSRLLGLDVREGRHEGPIYTLDMGQGRPGITLDNHCFDENYVFTPSNQPLFNLSASDIHEAYRHVTELGAEIVNGIVTYPDLAEFSFQDPAGNIIMVCTCFS
>NC_015690.1|WP_013916714.1|3125837_3126860_+|YafY-family-transcriptional-regulator
MTKSKRLMELMIAVNKRRRFTVRELAEEFGVSTRTIMRDLQVLDELGLPLYAEYGPHGGYRVLNERLLPPIMFSEQEALAMFFAYQSLQHYGALPFSEESVTALKKFYYYLPDDTKQKIDRLQERVVFWTPKRQAAVPHLKLLLDASLQGRPLRITYDSREGPGERAVQPIGVYSYNGYWYCPAYCFRKQRYLLFRVDRVLQAEPAGEDHPAVDLSEYTITDWFLPPPQQPAGPGGEAQGLLQLEVRLTKDGVRRCRWESWFQEELVVGEEGEGLLRIRIRHDEMDYYTGYFLSLGADAVVVQPPELVSRLREAVRKLYDAYGAGETDGPPSQAGSVTGM
>NC_015690.1|WP_041616901.1|3126799_3127312_-|GyrI-like-domain-containing-protein
MKPRIERHGEFAAVGTKGQHRLTEGVIPTIAVQWDAFMRRAAEIPGRGPATLGICWGIDAASGEPFDYLTGALVENMPPELPSGMTAVTLEPRLYAVFTHRGPVARLDATYASIQAWLESNGTYRRADAPDFEYYDHRYASAEPESSEFDIYIPVTEPACDGGPSVSPAP
>NC_015690.1|WP_041616902.1|3127522_3128536_-|NAD(P)-dependent-alcohol-dehydrogenase
MRAFEIQGGFGLERITLAERPKPAPGPGEVLLRIRAASLNARDLGVAGGFYVGAETLPLIPVSDGVGIVEELGEGVTRVKPGDRVCPIFVQDWLAGTPTEAMLGSTLGGPRDGVLAEYGVFPQESLVHVPEHLTDEEAASLPIAALTAWQAVVTEGRVRAGDTVVVQGTGGVALSALQFAKLHGARVIVTSSSDVKLERAAALGADLGINYVKSPQWDQEVLRLTDGRGADHIVDLGGAATLNASLAAVRPGGRVSIVGVLSGVTAAGLDLIPAIRKKVTLQGINVGSRGMFEDMNRALALSGVRPVIDRVFPFTEAVQALRYMQEGVHFGKICIRL
>NC_015690.1|WP_013916716.1|3128674_3129076_+|helix-turn-helix-transcriptional-regulator
MRTDGRPEKDISVAVCSYSLALDVIANKWKPLVIYALENGSQRYGDMKRRIEGVSQKMLTETLRGMERDGLVVRKVHPAVPPAVEYTLTPLGRTLIEPLQALHVWAKAHHEDVLSARERYDGQDGQDGQTGGA
>NC_015690.1|WP_013916717.1|3129271_3130066_+|helix-turn-helix-domain-containing-protein
MTTVQSKDSAIFLVLADPRCRELLQRLAASPGLSVSGLSDELELPRAAVLKHLKMLEEAELAASRRIGREKLYSADRERLRGLMERLLGRPEDTRGGRLGELKRMLSEEKQRSVRMLPRQTYGTLIRSSPARIWEEVLSPEQPAGFWRGCRLILGGGELSPYRLERPDGREEARGMVTAAEAQRRLELTWGSPDESEAGTAEGRLALELERLPGRPEVCRVILVLTAEIRTEDSIRAADGGWPGRLAGLKSYVETGEGMWEEKP

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Crispr_ID: NC_015690_18

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015690_18

3596916-3596989

Orphan

Consensus_repeat	Method
ATAAGGCATCTGAGTTCCGCTAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015690_18

>merge|NC_015690|18|3596916-3596989|CRISPRCasFinder
ATAAGGCATCTGAGTTCCGCTATTTGTTGGGAAATGACGGGAAATACCGGGATAAGGCATCTGAGTTCCGTTAT

>NC_015690|18|12|3596916-3596989|CRISPRCasFinder
ATAAGGCATCTGAGTTCCGCTAT	TTGTTGGGAAATGACGGGAAATACCGGG
ATAAGGCATCTGAGTTCCGTTAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_015690.1\|WP_013917174.1\|3597281_3598268_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381302
NC_015690.1\|WP_041616955.1\|3595516_3596506_+\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NC_015690.1\|WP_013917169.1\|3593433_3594381_-\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013917163.1\|3584752_3585418_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224922
NC_015690.1\|WP_013917181.1\|3602593_3603403_-\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013917167.1\|3589139_3589688_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|292911
NC_015690.1\|WP_013917180.1\|3601945_3602449_+\|signal-peptidase-I	unknown	unknown	gnl\|CDD\|274044
NC_015690.1\|WP_143768132.1\|3598598_3598781_-\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013917172.1\|3595119_3595311_-\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013917184.1\|3612363_3613779_-\|SpoVR-family-protein	unknown	unknown	gnl\|CDD\|377285
NC_015690.1\|WP_013917164.1\|3585410_3586430_-\|methionine-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|236863
NC_015690.1\|WP_014368889.1\|3587191_3588100_+\|ribokinase	unknown	unknown	gnl\|CDD\|238579
NC_015690.1\|WP_013917166.1\|3588378_3588801_-\|TIR-domain-containing-protein	unknown	unknown	gnl\|CDD\|378100
NC_015690.1\|WP_013917185.1\|3613775_3614936_-\|sporulation-protein-YhbH	unknown	unknown	gnl\|CDD\|274336
NC_015690.1\|WP_013917183.1\|3611750_3612149_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NC_015690.1\|WP_041616957.1\|3603724_3611560_+\|carbohydrate-binding-protein	unknown	unknown	gnl\|CDD\|224389
NC_015690.1\|WP_013917168.1\|3589922_3593108_+\|cytochrome-P450	unknown	unknown	gnl\|CDD\|223446
NC_015690.1\|WP_013917177.1\|3598993_3600241_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340883
NC_015690.1\|WP_013917162.1\|3583850_3584693_-\|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270315
NC_015690.1\|WP_081473184.1\|3600411_3600936_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_015690.1\|WP_013917174.1\|3597281_3598268_-\|aldo/keto-reductase	gnl\|CDD\|381302	cd19076, AKR_AKR13A_13D, AKR13A and AKR13D families of aldo-keto reductase (AKR). Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.	0
NC_015690.1\|WP_041616955.1\|3595516_3596506_+\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	6.65037e-60
NC_015690.1\|WP_013917163.1\|3584752_3585418_-\|ABC-transporter-permease	gnl\|CDD\|224922	COG2011, AbcD, ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism].	3.45996e-104
NC_015690.1\|WP_013917167.1\|3589139_3589688_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|292911	pfam16295, TetR_C_10, Tetracycline repressor, C-terminal all-alpha domain.	1.14867e-74
NC_015690.1\|WP_013917180.1\|3601945_3602449_+\|signal-peptidase-I	gnl\|CDD\|274044	TIGR02227, Inactive_signal_peptidase_IA., signal peptidase I, bacterial type. This model represents signal peptidase I from most bacteria. Eukaryotic sequences are likely organellar. Several bacteria have multiple paralogs, but these represent isozymes of signal peptidase I. Virtually all known bacteria may be presumed to A related model finds a simlar protein in many archaea and a few bacteria, as well as a microsomal (endoplasmic reticulum) protein in eukaryotes. [Protein fate, Protein and peptide secretion and trafficking].	3.14529e-39
NC_015690.1\|WP_013917184.1\|3612363_3613779_-\|SpoVR-family-protein	gnl\|CDD\|377285	pfam04293, SpoVR, SpoVR like protein. Bacillus subtilis stage V sporulation protein R is involved in spore cortex formation. Little is known about cortex biosynthesis, except that it depends on several sigma E controlled genes, including spoVR.	0
NC_015690.1\|WP_013917164.1\|3585410_3586430_-\|methionine-ABC-transporter-ATP-binding-protein	gnl\|CDD\|236863	PRK11153, metN, DL-methionine transporter ATP-binding subunit; Provisional.	0
NC_015690.1\|WP_014368889.1\|3587191_3588100_+\|ribokinase	gnl\|CDD\|238579	cd01174, ribokinase, Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides and histidine, and for entry into the pentose phosphate pathway. Ribokinase is dimeric in solution.	2.08419e-126
NC_015690.1\|WP_013917166.1\|3588378_3588801_-\|TIR-domain-containing-protein	gnl\|CDD\|378100	pfam08937, DUF1863, MTH538 TIR-like domain (DUF1863). This domain adopts the flavodoxin fold, that is, five parallel beta-strands and four helical segments. The structure is a three-layer sandwich with alpha-1 and alpha-4 on one side of the beta-sheet, and alpha-2 and alpha-3 on the other side. Probable role in signal transduction as a phosphorylation-independent conformational switch protein. This domain is similar to the TIR domain.	9.36507e-07
NC_015690.1\|WP_013917185.1\|3613775_3614936_-\|sporulation-protein-YhbH	gnl\|CDD\|274336	TIGR02877, Stress_response_UPF0229_protein_YhbH, sporulation protein YhbH. This protein family, typified by YhbH in Bacillus subtilis, is found in nearly every endospore-forming bacterium and in no other genome (but note that the trusted cutoff score is set high to exclude a single high-scoring sequence from Nitrosococcus oceani ATCC 19707, which is classified in the Gammaproteobacteria). The gene in Bacillus subtilis was shown to be in the regulon of the sporulation sigma factor, sigma-E, and its mutation was shown to create a sporulation defect. [Cellular processes, Sporulation and germination].	0
NC_015690.1\|WP_013917183.1\|3611750_3612149_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	2.97567e-08
NC_015690.1\|WP_041616957.1\|3603724_3611560_+\|carbohydrate-binding-protein	gnl\|CDD\|224389	COG1472, BglX, Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism].	3.84084e-87
NC_015690.1\|WP_013917168.1\|3589922_3593108_+\|cytochrome-P450	gnl\|CDD\|223446	COG0369, CysJ, Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism].	1.54508e-171
NC_015690.1\|WP_013917177.1\|3598993_3600241_+\|MFS-transporter	gnl\|CDD\|340883	cd17325, MFS_MdtG_SLC18_like, bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters. This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.77971e-24
NC_015690.1\|WP_013917162.1\|3583850_3584693_-\|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270315	cd13597, PBP2_lipoprotein_Tp32, The substrate-binding domain of the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum binds L-methionine; the type 2 periplasmic-binding protein fold. This group includes the lipoprotein Tp32, a periplasmic component of a methionine uptake transporter system, and its closely related homologs. The Tp32 has both structural and sequential homology to the MetQ family of substrate-binding protein, and thus it belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.	1.8307e-130

>NC_015690.1|WP_041616955.1|3595516_3596506_+|Gfo/Idh/MocA-family-oxidoreductase
MIRFGIIGTNWITETLIEAALRTGKVTFTAVYSRTEEKGREFADKFGIPHVYTDLETFGESTEFDAVYIASPNSLHAKYAVQLMNYGKHVLCEKPLASHAREVREMIDAAKSNNVLLMEAVKSTLMPSFRAVQEHLHKIGPVRRYTASYGQYSSRYDAYKQGTVLNAFKPEFSNGSLMDLGVYCIYPMVVLFGRPQRVQAEAFMLESGVDGEGSLLLKYEGMDAVIMHSKIANSYLPAEIQGELGTIVIDRINEPGRVEIRYKDGRVEDLTQPTEHPSMYYEVLEFAALLEAGATESAVNSHGSSLAAMQVMEEARKQIGLVFPADSES
>NC_015690.1|WP_013917172.1|3595119_3595311_-|hypothetical-protein
MRTEDQIRRKANELLLQKKSVEERLTAAEEDRKPGLQSELDRLDDMILLLEWVLNKPVGSYHG
>NC_015690.1|WP_013917169.1|3593433_3594381_-|hypothetical-protein
MKKKPSCAAPLLLLLLAACSSISTPADVGNIESPANGAGGSTASVPTAVGTETAASGPAYVKPEDLKAVPLVFGRIESPALEKTAAPETASPAKVYECSAAPGLPSCSVHLYEERADNGYIGVRVFLRVPDGWYAAGGSIAGDADSLAVRFLPQGSGPAEDGPMELAIGGAPDDSYAGPVRTLFYDAEKRVWRMQDFQGHDVQRLDLNQDGQAEWVSPSAGSVPPSVGIYRWNSSARAYEYTVVENVAAAAFGLALEQVPLHAYLFKESGEWIIETGPSDRYGFFRQEGDQLAPARLTDEHSRLMDLRRTQDHRH
>NC_015690.1|WP_013917168.1|3589922_3593108_+|cytochrome-P450
MTQTSQIPQPKTFGPLGNLPNLNTKEPVQSIVKIADEFGPIFQLDLPRGKSVYISSHELVADACDESRFDKYVWAPLQKVRAFAGDGLFTAETDEPNWQKAHAILLPSFSQRAMQGYHAMMVDLAVQLVQKWARLNPDESVEVGEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMSQLQRLGLQDKLMVISKRQYKHDIQTMFGLVDKIIAERKEHGPKDGEDLLAHMLNGRDPHTGEALDDENIRYQIITFLIAGHETTSGLLTFALYFLLKNPEKLAKAYEEVDRVLTSPLPTYSQVRELKYIRMILNESLRLWPTAPAFALTAKEDTMLGGRYPMKKGDSVSVLIPKLHRDPSVWGDDVESFIPERFEDPSSIPPHAYKPFGNGQRACIGQQFALHEAVLVLGMVLRHFEIIDHTNYQLKIKETLTLKPEGFTMRVRSRIEPQAVVMPGREAAPLEEKREQAAEAAPVPKHNTPLLVLYGSNLGTAEGIARELADAARYQGFSSETAPLDEHVGSLPKEGAVFIVTASYNGSPPDNARAFVQWLEQAEPGSLDGVRYAVFGCGDHNWASTYQQVPRKIDALLADKGAKRLAGLGEGDVSDDFEQQLESWRGGLWPQVMEAFGLSLNENAGQERSSLTVQFVSGLIGTPLAESYDALQTTVAENRELQGEGSDRSTRHIEVVLPEEVSYREGDHLGVLPLNPKDLVGRVLQRFGLQGGDHLVLSATGRSAAHLPLDRPVRLSDLLGSSVELQEPATRAQLRELAAYTVCPPHKRELEALLQEDAYKTEVLRKRVTMLELLEKYPACELPFERFLELLPPLKARYYSISSSPRVLGDRVSITVSVVRGPAWSGRGEYRGIASNYLAERKPGDPVVVFVRSPESGFELPEDPSTPVIMVGPGTGVAPFRGFLQARRVLQAQGAELGEAHLYFGCRNPQHDYLYREELEQAEKDGLVVLHTACSRVDGQEKTYVQDLMKGDASLLIGLLDRGGKLYICGDGSRMAPDVEATLRRAYSEIHGVSGQEAADWLDGLARENRYAKDVWAGTAG
>NC_015690.1|WP_013917167.1|3589139_3589688_+|TetR-family-transcriptional-regulator
MSAALELFAEQGFETTTVPMIADKAVVGAGTIYRYFTNKEALGNALFQDCVRQFSEAIQLGYPAEGNAREQFRHIFCRMVEFAKEQERAFYLLETHRHARYLSEESHELFREMMEFLRAYFRAGREQGTIRSMPSDALIAIVYGAFAALYKAIRAGKIQETPDLIDSVEQACWDAVRVHPHG
>NC_015690.1|WP_013917166.1|3588378_3588801_-|TIR-domain-containing-protein
MTVYDTNRVYTLYLSHTWNDRGTGGELLRMLQSVDSFRFRPASLDRQTSEAADDRILYEAIRGKIRYADVILILCGVYAEYNRWVNKELILAKNELNKPVIGVQPFPAEKTPFIVKQHADRIVQLHPLDIIKAVMELGQG
>NC_015690.1|WP_014368889.1|3587191_3588100_+|ribokinase
MKRPRIAVVGSLNMDLVVSMPRMPQVGETVHGTDIHYIPGGKGANQAVGCARLGAEVSMIGAVGSDHFGREMLERLQEEGIDLGGVHTAEGPTGTAAIFHTAEDNCIAVVPGANAYCTPELVERHRERIESADVLLVQLEVPLDTVHRALEIARQAGVRTVLNPAPAKVLPAPLLSLADILTPNETEFALLSGEQDTSEEVLRRVMIAWQQDYGHTVILTRGRLGSSWLDEGERLRTEPALPVETVDTTGAGDAFNAALCFGLASGWDLQQAADFACRAASVSVTRFGAQAGMPRLEEVPER
>NC_015690.1|WP_013917164.1|3585410_3586430_-|methionine-ABC-transporter-ATP-binding-protein
MIQLQGVSKQYTSGRGTVTALQKIDLTVNKGEIFGIIGHSGAGKSTLIRTINLLEKPTGGTVIIDGVEMTKLSSRRLQEERRSIGMIFQHFHLLSSSTVADNIAFPLRLSKRPEAEIKQRVQELVGLVGLSGHEHKYPSQLSGGQKQRVGIARALATNPKVLLCDEATSALDPQTTNSILSLLLDINRKLQITIVLITHEMHVIRTICDRVAVIDGGHIVEMGPVTDVFLKPQHPTTRDFVAQLAEDPETTLAETGAEASGRIRIRVTFLGEQTYEPVLFETMRETNVPFVILQGTVSRLKDTPYGQLLLELRVNTAEAEAAIAALRRRGLDVEVIQHG
>NC_015690.1|WP_013917163.1|3584752_3585418_-|ABC-transporter-permease
MAEFLKDIVWEDISLATYDTLTMLGLSTLFTVVIGLPLGILLFLTSRGQLLQQNALYALLSFVVNVLRSVPFIILMILVIPLTRVIVGTSIGVPGSIPPLVIASAPFFARLVETALREVDRGVIEAAQSMGATSGQIVTRVLLPEARPGLIAAITITAVTLVSYTAMSGVVGGGGLGDLAIRYGYQRFNTPVMVVTVVILLVLVQILQSLGDRLVRRFQRK
>NC_015690.1|WP_013917162.1|3583850_3584693_-|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein
MKKPLTLALSLVMAFSLAACGTKPAEQAAPAPSNGAAPAKEVTLKVGATAVPHAEILNSVKDKLKAEGVNLEVKEFTDYVQPNVQVFEKQLDANFFQHTPYLDDQNKAKGMNLVKVTGVHIEPFGAYSQKIKKADELQDGATVAIPNDPSNSGRALALLEKNGLIKLKDGAGISGTVKDIVENKKNLKIKELEAAMLPRVLPEVDLALINTNYALEAKLNPTKDALFIEDSNSPYVNNLVSRPDNKDSEAMQKLAKALNSPEVRKFIEDKYQGAVVPAFK
>NC_015690.1|WP_013917174.1|3597281_3598268_-|aldo/keto-reductase
MKTRTLGRSNLEVSSLGLGCMGMSDFYSGRDEEESIRTIHRSLELGVTFLDTADMYGVGRNEELVGRAVKDRRDAVVLATKFGNVRSEDGQFLGVNGRPEYVRSACEASLRRLGVDHIDLYYQHRVDPNTPIEETVGAMAELVREGKVRYIGLSEAAPATMRRAHAVHPVTALQTEYSLWSRDVEDEILPVCRELGIGFVPYSPLGRGFLTGQIRRFEDLAEDDYRRFSPRFQGENFQKNLDLVERIREIAAARNVQPSQLALAWLLAQGDDIVPIPGTKRTVYLEENVGALDIELTPEELGRIDEAAPKGAAAGSRYPEASMSSLNL
>NC_015690.1|WP_143768132.1|3598598_3598781_-|hypothetical-protein
MRNGKEVERMHYFELELHMTERQQIIRQKSRGLLRRSIKQVWRTTHEYTMTLLACISLAG
>NC_015690.1|WP_013917177.1|3598993_3600241_+|MFS-transporter
MGDGEAMDEDRIINFSGLRMSRDTWHNFRWDVAAASVFSLFNVVFNQFYIPIALRHGASDFEVGLLAAAPAVGLLFSPAWAGLMEGRSPKPFFLLPNLIGRLLLIIPALYSTPVMFVLTAFLFHLLMGIQAPAYAALMTRLYPADQRGRLMGNVRVIMGLLMLPLAWVTGLWIDASGSSGPLLVAAVTGALSLIAFQQVREVPRFFAGGKGEALRLSLFGQLRLLRGNRPVLIFLAATSLAGFGNMLASPLYAIYQVNELGLSNAQIGYLRMAYFACMLLAYLIAGWAIDRFSPQAVMACGLTAMTTVPFLYGLVGTFPAVLAASGIQGISDAVWDIGCMAFVFHFARGREAVVFGLHLMLFGIRGTAGPLIGTSLNGAMPFGGMMLFVGALGLAGLLLFLGSRIRSEDGVTAEE
>NC_015690.1|WP_081473184.1|3600411_3600936_+|hypothetical-protein
MQRGLRPMTVISFLLPVLLLGGGSGNRPGKKLGETALRMAGKVDCSAYPPAHGDATMLPEGTAVHEARGYAKTFRLLAGDRVYEVMEERRFDSELTERLTELYLQRERIGEPEILKRGVPKAEYVYNLEFHLRDGSEAGTTYLSGSDYLGSGALLGSELEKALKDITQKEFGRP
>NC_015690.1|WP_013917180.1|3601945_3602449_+|signal-peptidase-I
MLHFILALLLTTGIPGTTPAVKSYQAMGPSMEPAIHQGDRLGVDTEYYQTNAFRRGDLVLFPVGEDKIYFKRIIALGGERVRVDGDDVYINGTKLDEPYLADGLKRAAELGSPYNVRDFAEAVVPKGAVFVMGDNRSNSMDSRDAAVGFVPYASILGRVVTVQHTDE
>NC_015690.1|WP_013917181.1|3602593_3603403_-|hypothetical-protein
MNMNGTYGGARSIDEVLLQLDRVVEEARSSSSRLGYFAALYRMVTRKVKEGIAQGFFEDGPRMERLDVIFANRYLEALNAHLHGGRPTDCWALSFRSAGNSRLLILQHLLLGMNAHINYDLGIAAAQTSPGAEIGSLYADFNKINSILAGLVGRVVDEIQELSPWIRLLDRIDTKAEFAVINFSMMKARDCAWQVAERLALGDDAADTPYLLQLDNDVTYLGGKVADPGFWLNLGLGVIRSRESSDIPRVIDVLSGTGTDAAPPLDQAV
>NC_015690.1|WP_041616957.1|3603724_3611560_+|carbohydrate-binding-protein
MTAAVVLGSTLAAPFTASVSAAESPAELAPYWNPKLPVEERVQDLLGRMTLDEKVGQMVQAERAHATPEDVKMYYLGSMLSGGGYFPGGRQANSTREKWAELYDSYQNGALSTRLGIPLLYGVDAVHGHSNVIGATLIPHNIGLGAARNPELMKKLGALTAKEMRATGVNYAFGPTIADVQNPRWGRTYEGLGDDSVLAGQLGAAYIQGLQGAGGGELSRPDKVVATAKHFMGEGYTDNGTNQGDVSTKTYTEEEIRELLERELAMYKQAVDAGVKSVMASYNSIQGLKMHANKPLLTDKLKGELGFRGFVITDWNGVDQITKDWEGRPVSGLKEQVRAAVNAGVDMFMEAEKWRDIVRYLKENVNEGGIPGERVDDAVKRILRVKFESGVFELPKTNGDLAPSFGSAEHRELARQAVRESLVLLKNDKVNGQPLLSKLPSMKKIFVAGKNADDIGNQAGGWSITWQGQSGPTTPGTTILQGIREAAGDMRTVTYNKHGRGAAGYDVAIAVLGEKPYAETNGDTASLELDVEDLATLENIRTADPDIPILVVLVSGRPMTVTEPMKDWAGLIAAWLPGTEGAGVADVLFGGHDFTGRLPMRWPFYVEAYPIKTADSPYILFPTGYGLTKGEMTPELPPVPEKPGQPAYSPKPVPGRVEAEDFTAQNGLQLENASEGTQNLGFADAGDWSDYTVNVAQAGTYEVDFRYAGEMGSPTSIRIKDEAGRTAGTFSGGATGGWQSWRTGTAVNVVLKQEGVQKLRLEFGGSINLNWLEFRRTGDVPADNSGGGDSGSGAVVKSGAVESWITNERDPGDIRWYYAPRYREGDKKLEAQPKLDLVMPGGGSGTEIKLDPEKTYQSMFGIGSSMEESTVHNLWKMSPAKRTEVLKKLVDPQEGAGMSLIRLTIGSADFTAQTFYSYDDMPAGGTDPELKHFSIQKDREFHIIDTVKEIQRINPDVKFFASPWSPPGWMKTTDSLMKGQVKDEYLPVLAKYYLKYLQAYRAEGIEIEAMTMQNEPLLEIEYPSAKMPWEQQAKLAKLLRAELDANGFSHVKLWTFDHNPGDTMAYPAQLLRDPANREAVDGTAFHDYGGDLGEMTKLHDMYPEEHVYLSERAVWGTKGADRMAQYFRNWARSYNSWVVMLDSDIRTHQWVGTPDPTPLVQDSADRDNYWLAPEYYLLGQYTKFVEPGYVRIDSNYGSADTVTNVAFRSPDGKKIVTVVINQTNEDQLVKLLSDGTQITATVPAKSVVTYRWDRVVAKQAVPGTIRAADFDHAAGSYKADGETGTVGGLNEGTGEPASFDYLVNVAESGTYYADLGYTGVPQDASLRLLKDDAESAAVPLSQEVSGGGPAGYARVSVSLEAGIHKLTLTAQGRGYTLTDLVLSKADPGLHSVPGLIEAEGGTLLPGTLADRSADGVIVGFTPDAEGAEYRFHAEQGGEYRMTYRYAAEGVGAAAELSVGGTVIGTTYLPVTGGRDQWAYAADTVTLPAGDHVLKLAVKDSPVRLDWLAVGPTMIAAAGAPVTEGQENGTPITVELLNDTFRETLHAERWSLEGAEGVSVGSVTRLDDRRAQVVLSGTRTPDYDKDIRGAVTAAVYETVSGSVYASGVLRSRLAFTAVDDAETLVMADGPLPYGVDGRVLELALEGGTFRTGALDGITLAGSAVTQGGVSLKSVRAVDASHLELTLGWNGTAYYGDLQLEVRVPKEAYADGGEAALTAAAVLSGTVNRQEAVPVPGLVPADAFYKVQGAAADAGPDGTRKLTGFDAGDYAEYKIGAAQAGTYLAALRITFESGAAKGIVLKNGAGETLAEYTVPQLYNKNWVTVGSRITLPAGEQILRVYAQAGGFELGSLTLEPVTAQVMDEQGVLRVEAESYTGATVGVIQDNAASGTAPAFRNVGYMSAGNTLDYLVDVLEDGYYRVTYRYSTAQGGVSAAFTVGGQVLGTAQLPATGGWGTYKEASHVVSLRKGVQTITLLDQGDGFNLDWFELQPSDAPEQVVTDQAAVPAASLRAGTYYGSREAALSTVTEGAAVFYTLDGTVPTAAGTPYTGPIKVTGLTVIRAIAVKAGMKDSYVAPYTYVVEAGEQPPEQASAPAASPGPGSYTAPQQVVLTTATEGAVLYYTLDGSTPSAAAGTEYKHAITVPVGTTTVKAIAVKEGMADSPAVEFTYVITAPGNGGGNNGGGNNGGGNNGEGNNGGGSDDDSSGGGSQPGSGGGGTPGGGAGSKPAPADGGPPVLTTPQPALDAETGIASVTVPAAELEKALAGRSFVSVHVPQTAGAKTYGIVLPASVLTAGSEKHTLEVVTEVGRLTLPSGMLASAGGAQQVELRIGSADPSSLSASLRGQLGGRPVIELSLFADGEPLEWSNPDAKAAVSIPYKPDAEELAHPDWITVWHVDAAGAVTAVPSGRYDGESGRVTFATTHFSRFAVAYVTKAFGDLTAHAWAREAVETMAAKGVIEGTAEGTFTPSAPVTRADFLLLLVKALDLSAGFTGNFDDVDPSAYYYQAVGIAKKLGITEGREGKRFDPASPISRQEMMTLAERALKLAGRELPAGDESVLGGFADRADLSAYAAESTAALVKSGLITGDGSRLNPLGTATRAETAVLIHRLYQR
>NC_015690.1|WP_013917183.1|3611750_3612149_+|helix-turn-helix-transcriptional-regulator
MSTWYGQRLRELRELKGMEVTEFAKELGVSPGYLRNLETGRTQTIQLEILSRLEKELYWSVDEELAKEEEAEEEAAREPEDSPRLDRALRELRELTAADPPAGEYLLGMLEQGLRLVRDRRQPDMPPAAASE
>NC_015690.1|WP_013917184.1|3612363_3613779_-|SpoVR-family-protein
MKLDDIKKLEYAIAEITEVATGFGLDFYPMRYEICPAEIIYTFGAYGMPTRFSHWSFGKTFHKMKMQYDFGLSKIYELVINSDPCYAFLLDGNSLIQNKLIVAHVLAHCDFFKNNVRFSKTNRNMVESMSATAERIRQYEIEYGNEEVEKFIDAVLAIQEHVDPLITKPVRGMSGLRTEAAAPPTERTFGYEDLWDLDEKPKPPERKEGPAKFPPRPEKDLMLFIEEYAPYLKDWQRDIMTMLRDEMLYFWPQMETKIMNEGWASYWHQRILRELDLTEDETIEYAKLNSSVVVPSRHSLNPYYLGLKIFEDIEKRWDHPSKEDRERFGYKGGEGRQKIFEVREFDSDSSFIRNYMTKQLVDELDLYVFEKKGPEWKITDKSWENIRDQLIFARVNGGFPYIVVEDGDYERSGELYLRHMFEGTELDLKYVERTIPYIHRLWGKPVYLESVIEGKPVLFSYDGRKHNRKFL
>NC_015690.1|WP_013917185.1|3613775_3614936_-|sporulation-protein-YhbH
MTEPLFTVSREDWSLHRKGYQDQTRHQEKVREAIKQNLPDLVTDESIVMSDGKQIVKVPIRSLDEYRFRYNYNKSKHVGQGDGDSQVGDVLGVDPQPAKGSGKGEGAGDQPGDDYYDAEVQMEELQTMLFEELELPNLQQKEKNNVTTKEIIFNDVRKKGIMSNIDKKRTIMENLRRNSREGTPGIHHISPDDLRFRTWDEIVTPHSNALILAMMDTSGSMGSFEKYIARSFFFWMTRFLRTKYEHVEIVFIAHHTEAKEVTEEEFFTKGESGGTICSSAYQLAVDLIDRKYPPSRYNIYPFHFSDGDNLTSDNERCVKLIGELVKRANLFGYGEVNQYNRSSTLMSAYRNIHDPKFVHYVIREKGEVYKALRTFFPKNVEGRAAR

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Crispr_ID: NC_015690_19

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015690_19

5790623-5790716

Orphan

Consensus_repeat	Method
GGTCACTGTCAAAACCATATATCCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015690_19

>merge|NC_015690|19|5790623-5790716|CRISPRCasFinder
GGTCACTGTCAAAACCATATATCCTCGCTGGGTATAGAAGACCCCATTTCCGCTTGGCTTCGCACAACCGGTCACTGCCAAAACCATATATCCT

>NC_015690|19|13|5790623-5790716|CRISPRCasFinder
GGTCACTGTCAAAACCATATATCCT	CGCTGGGTATAGAAGACCCCATTTCCGCTTGGCTTCGCACAACC
GGTCACTGCCAAAACCATATATCCT

Protein	Signature genes	Signature genes Name	Protein_function
NC_015690.1\|WP_013918881.1\|5787774_5789418_+\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NC_015690.1\|WP_013918879.1\|5786629_5786848_-\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013918889.1\|5796659_5797754_-\|DUF4163-domain-containing-protein	unknown	unknown	gnl\|CDD\|377924
NC_015690.1\|WP_013918877.1\|5783834_5784704_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NC_015690.1\|WP_143768149.1\|5798375_5799473_+\|DUF4850-domain-containing-protein	unknown	unknown	gnl\|CDD\|292760
NC_015690.1\|WP_013918883.1\|5790184_5790484_-\|DUF2325-domain-containing-protein	unknown	unknown	gnl\|CDD\|378383
NC_015690.1\|WP_013918878.1\|5784805_5786530_-\|alpha-keto-acid-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|226470
NC_015690.1\|WP_013918882.1\|5789571_5789946_-\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013918885.1\|5790849_5793150_-\|ATP-dependent-helicase	unknown	unknown	gnl\|CDD\|223288
NC_015690.1\|WP_013918890.1\|5797879_5798185_-\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013918874.1\|5780868_5781057_-\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013918875.1\|5781278_5782652_-\|MATE-family-efflux-transporter	unknown	unknown	gnl\|CDD\|240539
NC_015690.1\|WP_041617275.1\|5796411_5796615_-\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013918892.1\|5799609_5800308_+\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013918893.1\|5800388_5801846_-\|DUF5050-domain-containing-protein	unknown	unknown	gnl\|CDD\|379846
NC_015690.1\|WP_013918887.1\|5794897_5796313_+\|PLP-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|224089
NC_015690.1\|WP_013918876.1\|5782926_5783760_-\|acetyltransferase	unknown	unknown	unknown
NC_015690.1\|WP_041617277.1\|5801869_5802742_-\|DUF4362-domain-containing-protein	unknown	unknown	gnl\|CDD\|372994
NC_015690.1\|WP_013918886.1\|5793296_5794751_-\|amino-acid-permease	unknown	unknown	gnl\|CDD\|236823
NC_015690.1\|WP_013918880.1\|5786929_5787607_-\|SOS-response-associated-peptidase	unknown	unknown	gnl\|CDD\|376837

Protein	Function_ID	Function_description	E-value
NC_015690.1\|WP_013918881.1\|5787774_5789418_+\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	3.72005e-54
NC_015690.1\|WP_013918889.1\|5796659_5797754_-\|DUF4163-domain-containing-protein	gnl\|CDD\|377924	pfam07833, Cu_amine_oxidN1, Copper amine oxidase N-terminal domain. Copper amine oxidases catalyze the oxidative deamination of primary amines to the corresponding aldehydes, while reducing molecular oxygen to hydrogen peroxide. These enzymes are dimers of identical subunits, each comprising four domains. The N-terminal domain, which is absent in some amine oxidases, consists of a five-stranded antiparallel beta sheet twisted around an alpha helix. The D1 domains from the two subunits comprise the 'stalk' of the mushroom-shaped dimer, and interact with each other but do not pack tightly against each other.	1.68896e-18
NC_015690.1\|WP_013918877.1\|5783834_5784704_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	5.37305e-24
NC_015690.1\|WP_013918883.1\|5790184_5790484_-\|DUF2325-domain-containing-protein	gnl\|CDD\|378383	pfam10087, DUF2325, Uncharacterized protein conserved in bacteria (DUF2325). Members of this family of hypothetical bacterial proteins have no known function.	2.04691e-16
NC_015690.1\|WP_013918878.1\|5784805_5786530_-\|alpha-keto-acid-decarboxylase-family-protein	gnl\|CDD\|226470	COG3961, COG3961, Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only].	0
NC_015690.1\|WP_041617277.1\|5801869_5802742_-\|DUF4362-domain-containing-protein	gnl\|CDD\|372994	pfam14275, DUF4362, Domain of unknown function (DUF4362). This family of proteins is found in bacteria. Proteins in this family are typically between 93 and 146 amino acids in length. There is a conserved IRIV sequence motif.	5.69596e-14
NC_015690.1\|WP_013918885.1\|5790849_5793150_-\|ATP-dependent-helicase	gnl\|CDD\|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	1.29927e-115
NC_015690.1\|WP_013918893.1\|5800388_5801846_-\|DUF5050-domain-containing-protein	gnl\|CDD\|379846	pfam16472, DUF5050, Domain of unknown function (DUF5050).	3.64975e-32
NC_015690.1\|WP_013918875.1\|5781278_5782652_-\|MATE-family-efflux-transporter	gnl\|CDD\|240539	cd13134, MATE_like_8, Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.	4.37686e-176
NC_015690.1\|WP_143768149.1\|5798375_5799473_+\|DUF4850-domain-containing-protein	gnl\|CDD\|292760	pfam16142, DUF4850, Domain of unknown function (DUF4850). This family consists of several uncharacterized proteins around 250 residues in length and is mainly found in various Acinetobacter species. The function of this family is unknown.	2.04151e-73
NC_015690.1\|WP_013918887.1\|5794897_5796313_+\|PLP-dependent-aminotransferase-family-protein	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	2.54713e-121
NC_015690.1\|WP_013918886.1\|5793296_5794751_-\|amino-acid-permease	gnl\|CDD\|236823	PRK11021, PRK11021, putative transporter; Provisional.	7.55782e-56
NC_015690.1\|WP_013918880.1\|5786929_5787607_-\|SOS-response-associated-peptidase	gnl\|CDD\|376837	pfam02586, SRAP, SOS response associated peptidase (SRAP). The SRAP family functions as a DNA-associated autoproteolytic switch that recruits diverse repair enzymes onto DNA damage. We propose that the human protein Q96FZ2:UniProtKB, the eukaryotic member of the SRAP family, which has been recently shown to bind specifically to DNA with 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxycytosine, is a sensor for these oxidized bases generated by the TET (tetrahedral aminopeptidase of the M42 family) enzymes from methylcytosine. Hence, its autoproteolytic activity might help it act as a switch that recruits DNA repair enzymes to remove these oxidized methylcytosine species as part of the DNA demethylation pathway downstream of the TET enzymes.	1.25044e-111

>NC_015690.1|WP_013918883.1|5790184_5790484_-|DUF2325-domain-containing-protein
MTMKRVAIIGGSQTGTFKKLGEKRGLLVEHHNGKTGGGPVDEYFQRIINKADVIIVLRGAIKHTSMWAVRELAEKKGKKIDYHDGFGASGALEKALQLV
>NC_015690.1|WP_013918882.1|5789571_5789946_-|hypothetical-protein
MIKTVWLGLLLALNPAADQTAPQPVDVADYYGTNPTLGDTSFAKTVSPHAGVPQFRVQGANPQQQADLTDGRWGDPGDVRVYRPAVANANENQGSHWLGLAGLLGLLGLRRGRAKRPASSTEEG
>NC_015690.1|WP_013918881.1|5787774_5789418_+|GGDEF-domain-containing-protein
MIKLRTLLILTITGIIILLTSLLGVLFTRHSTNEIKKEIGHSLAGTAYQMSDKLDNFMWSRAGEMEILTTLDIFKQGGDIPGVQTALDQLQTSFPSFSWVGFMNTEGQVLAATDGILVGTNIASRPVFKEGIKGRFIGDVHEAVLLAKLLPNPTGEPLQFVDISLPVKDHGGRTIGVLAAHMSWEWSREVQRTILEPQLHRSENLELFIVSRTDHTVLLGPEDTVGKPLEIDSVNRAQAGGSGWELAAWPDGRSYLTGYAYGDGYLSYEGLGWTVLVRQPESDAFARVAGLRSDFALAGTLAAMLFSVIGWFLAARITRPIYSLTEAADRLRTGEAAELPENRGFREMYILSRSLRSLVESLARTENELGDMKNLAHFDPLTGLPNRVALESYLETTLEEVEPRTETLAFLYLDLDGFKKVNDTLGHHTGDILLQKVAKRLTSLQQAGNITVRLGGDEFLHILRFPKESAFEETKRAAEEIIALLNKPFLVDYNRISIGCSIGAAFYPDQDENAGQILKIADECLYRSKRAGKNCVSFSDELTMKLQ
>NC_015690.1|WP_013918880.1|5786929_5787607_-|SOS-response-associated-peptidase
MCGRFTLTVSPEAILEQFDLPGGLEEYHPRYNVAPGQQVWAIVHDGEAKRIRQLHWGLVPFWAKDPKIGYRTFNARSETAAKKAAFREPMKHSRCLIVADGFLEWRVRSGKAKQPVRFRLKSREVYGFAGLWETWRGKDGTELATCTILTTQPNEIVREVHDRMPVILPREAERLWLDPGVEDPGQLQGLLQPYPAEEMYAYEVSPLIGNVRNDSAELLEELNSK
>NC_015690.1|WP_013918879.1|5786629_5786848_-|hypothetical-protein
MRPLVNDIELCTALVYQTEILVFAGREWVHRGKILAFTEHSVQIGERRFDRADCSFWMPQETEEEEVIAVCG
>NC_015690.1|WP_013918878.1|5784805_5786530_-|alpha-keto-acid-decarboxylase-family-protein
MSAKTDKDRSSAGRAEEAAVSLGRFLFDSLKREGVNEIFGVPGDYNFTLLDELERCEGMRFIGGRNELNAGYAADSYARLRGLGAMITTFGVGEMSAANAVAGAYSESVPLMHIVGTPKSAAQRERRLMHHSLLDGDYEVFRRAYGEITAYTAVLTPENAAAEIPKAIRTAKEKKKPVYLAVAIDLVDRPVVQAHGEPEPKLQRRTDHDVLEAASAHAKRLLGAAGRAVILSDLPVQRFGLGEPVQRLAEALNVPAASTMLGKGSFDEGHPSYIGVYGGAFGSEDVRRTVEDAGCLIAVGLVRSDGNLANFTAKLDTARLIEIQPDSVRIGEALYPGIRAEEMLRALEESGFRGGELPRVRHPYDEPAGDPEDAVTAKTYLPRFQRMLKEGDVVVVETGTLAYGMSEVRLPKGAAYIHQGAWQSIGYALPAAFGAAVADPQRRIVLFTGDGALQLTVQEISSMLACGGRLILFVLNNRGYTIEKYLNVRTERQPYNDIPEWSYTRLAEAFGGEAYTARVRTNGELDAAMAEAEAQCGRRLCLIELVPEDPMDAPPYLKRKRSYLEAQEAQRAKG
>NC_015690.1|WP_013918877.1|5783834_5784704_-|alpha/beta-hydrolase
MSLGGIIDMDGFPLAYRIEGEGPPVLIVGSETYYPRLFSQELRKKLQLIFVDHRAFVKPSRSIKPEDYTLERIVQDMEVIRTTLKLGRVTVLGHSGSAFIALEYARTYPGHTATAVLLNSAPTNSAERQQGSLRHFDETASPERKAKFERDIALLPGDIEREPERRFAHACIRMAAHSFYDPGVDAAPMWEGVYTNMEIIDHLWGRVFAEIDMLERLHEVKAPVWIGLGRYDYLVSPVSLWDGIEERCSHVKVTVFEHSGHNPMWEEPEVFDRMLTEWVDGKESNSSLI
>NC_015690.1|WP_013918876.1|5782926_5783760_-|acetyltransferase
MQAVFHERAVRVEEAEIRAVASRLTAIGEQEGNPHGVQVRRFGRVHAFLVKGIPDLYFNSVRGLGLEEGSEERIDEILDFYAEHGASCRFDIVPFGAQPELLRKLAERGYGQYGFHTALYGVVPELGLPTDPRDGQVIVRPLREDEFDLYAEIYAASFGMPAFLQPAVAANNRVLHGRAGWRFYLALYGDEPAAIGALHLEDGIGSLAAAATLPAFRRLGCQSALLLERLEEAARSACGLLVGQAAFGSASQANMERIGMKVAFTKSLWRKIDTGRG
>NC_015690.1|WP_013918875.1|5781278_5782652_-|MATE-family-efflux-transporter
MNTESLPTWKKLSLFAVTWPIFVDSVLRMMLGTADVYMLSRISDGVTGAVGLANEIIVFCILMFGFVGIGTSVAVAQFLGAGRAREASRISALAITVNFIFGLIVSLTLVVFGEGIMRLMNLPPEQTAIAKQYLTIIGSFIWIEALSYAISSIIRSNGQTRDVMFVTLGVNLIHVAGNYLLIFGHFGFPELGVTGAAVSTAASRLIGLVVLIVILYRRIPYPIRLKDYITWNSTYLKQILSIGLPSAGEHLSWQSQHMMIVSFINIIGTAALSTHVYVMNVSNYFMALGMAIGMGTEIIIGHMIGAGETKAAYHKLLRSLRFCFLLTAAVVGFASLFREQLMGMFTTNADIIAMGSGILLLSVILEPGRTFNLVVINSLRAAGDARFPVMMGVLSMWGVAVPLAYLLGIKLGMGLLGVWIAFTADEWLRGLIMLLRWRSRAWESKALTAPAAAGQGA
>NC_015690.1|WP_013918874.1|5780868_5781057_-|hypothetical-protein
MRIQVELSVAGQPVKTEELVIEETKLGELTDEEIEQAIEIKIRSWADRMISIAWEVVDEEGE
>NC_015690.1|WP_013918885.1|5790849_5793150_-|ATP-dependent-helicase
MHQRKDFFASKKEELGVSLNEVQKQAVRETEGPLLLLASPGSGKTTTIIMRIGYLIERMGVEPSRIKAVTFSRASAADMKERFARFFPGLEPVKFSTIHSLAFQVLREHFYKTRTPYHLIEGQVELEEETEGDGGQPADHPPLHKKFILRHLFKTIAGENITDEQMEELTTYISLVKNKMIPPERWDSVKTDVPQAHRVLIAYEEYKRAGSGKGLLVDFDDMLTIGNEILERDRELLRRYQRRYDYVLTDESQDTSLVQHAIIEKLVREHGNLCVVADDDQSIYSWRGADPSYLLNFKDAYPAALTLFMEQNYRSSRDIVDVANRFIKRNKNRYEKNMFTRNPRSAPAQIRSFADYKSQAKYLVEEIRGIAELGEVAVLYRNNSSSIALINEFDRAGIPFFMKDTDNRFFSHWVVEDVLNFMRMSFTDKRADLLETIHTKCAGYITKGQMTQLLGIGNQESVFDNLLKHVPLKEYQVKQIELLRDNFRRMHGMAPKDAIRHIRGKLGYEKALDRLCERLGFRKEHLLGILNTLEEIADTLATMEEFAARLKHLEGVLKSSKHKKGQNVVTFSTLHSAKGLEFERVYMIDLIDGIIPSSDDKQGATAEEAALSMEEAVRLFYVGMTRAKRHLELLTYKMRDGEKVQESPFVTDVRQLLNPGKPAVRPEPGRPAAAVTSGRVPAAAQAGAGLAAASGKSASPARKKNPNAVRQAADLAAGRDVLHPVFGSGTIVKLAGERIHIRFGTTDKVLSVATCLEMGLLELEKS
>NC_015690.1|WP_013918886.1|5793296_5794751_-|amino-acid-permease
MNHARKRGSGAAAQITPQGKQAGAEAFRTEALPGPGKPIAPDNGSNQGTHAAPGADGRPGETVVDGRSGMRPSLGLPQIVALYLGSVIGSGILLIPGLAAEQAGPASILAWLAMSILVVPMAVTMGWLAARHPGPGGVSHFVRLAYGAPYGNLTGWFFLLSVPLGGPVLAVTGARYLAVLLHWNAEQVYLTAAVIVLLPLLLNVYGLHLAGRLQTVVVAVILGVLVLSVTAAVPHVDTARLTPFMPHGPLSVVQAAGLMFWCFIGWEAVTHLSGEFVDPRRNAVRGILWSAGIVALVYLAVAFTTVATGSYGGENSAASLSLMVQRSLGAAGGWAVAVAALFICLAAHNAYSSAASRTAYALAQEGAAPKWLGALHPRYGTPVGGLLFIAAGSMAALLLLYSEAVSLAELIALPNAAFIATYIGGCMAGVRLLRDGRWGRRCAGLSLAAVLALYPFLGWPALFPAGAAAILFLRQVRRRNANQV
>NC_015690.1|WP_013918887.1|5794897_5796313_+|PLP-dependent-aminotransferase-family-protein
MFDLSLTNQEELPLYRQLYEQLREGIRDGRIADGSRLPSLRSLRAQLNISKVTVETAYGMLVAEGYAVSRPRSGLYAVRPKGIPPRSSAADPAAPAVAPAPPAAALQEHRIDFRPSAVDPHSFPLRIWRRMLHQASETAAGQLGRYGDPQGEEGLRRVLADYLRTSRGVVCLPEQIVIGSGIGYSMGILARLFTAKSPIAVEAPGYAPVREQWRHCGYEVIPLPAGRQGWALDELGNTGAQVAYLTPSHHFPTGMVMPYAAREQLLSWAHSRDAYIIEDDYDGEFRYEGRPLPSLQSLDRDGRVIYIGTFSKVFSPALRMNYMVLPIRLASLLRSRPDLLHAPSRMEQWAMHAFIAEGHWYRHIRRMRRAYRRKHETLVRGIRSRWDGRIEVTGHSAGLHLEITVHTPHPAGSLTALAAEQGADVYDLRESWLEPAPDGPPRLYLGFGGLTEAEIDQGLTRLERAWEGLWA
>NC_015690.1|WP_041617275.1|5796411_5796615_-|hypothetical-protein
MSYNREVAEMAAGSKNELVRKDAGASEDMRAFLQSTASAGGRGDQKPDQNRKPDEQNKLTDQHNLRK
>NC_015690.1|WP_013918889.1|5796659_5797754_-|DUF4163-domain-containing-protein
MTNIHAHRKIRKTAVSLALAAVLAAGGSLSLAGASAETHEAAARYAITPQPVTVDGSSAVIPVIYSEGSTYIGLRALTEHLGLAIDWDAGERAASVTGRGRTLKVYPDTGVYTLNVNRLYGELPILQDGSLYVPLRFLLERLGYGVSYDQASRTIEVETIQENPLQIVTVTTDGGHPLVDAQYPQIEGFADTAVMGKINETLKKENEARIAEGIRQLGEAEKWNSELKTDNPEIETPQSAYSASYVVTYNENGRLSLYSDYYFYGGGAHGSTVRQGYTFDLKTGELLTLQEAAGSKDYVGIINREVQKQIGDTGLYLIAPFESVEPDRDYFLTHEGLVIYFQQYEYTAYAEGMPEFIIPYASFK
>NC_015690.1|WP_013918890.1|5797879_5798185_-|hypothetical-protein
MMGILFEVVGVLQENKVGFLFKQHTPMIDNQVFSILRLPTGNVKTIHKSMLGHPVRNMKLESGRIQICHGYCQEAQIGTMQERIERILMPKPQAEPAAQAK
>NC_015690.1|WP_143768149.1|5798375_5799473_+|DUF4850-domain-containing-protein
MPTSRLPSGPFRAAWALVCACTLLLASCEPGGGPSADPKAANPSAAASVEPARTPQARQPAEAPVQLSPGGESADTPAPSASPAAAPPSPASSQDNAPPPADANGQSSAAPGSAAHNPAAASAPPVPEPPPPAGAGQRPPGKQPRTEKNGKAAFEPAGAAKFEVPVVCVQANYGADPEGVTLCPPAPLSFKNYKLTAREASRMAVYWMSTGYGRGISVLAPGSWAVHDAAMGANGSVSFMLQHPNDPEQRIVYSDNGACQGCVIPNIGEFFPGMEAWAEEQGFPVEPVRDFARRIPIGLDLISYSLKRTKAGYETHGVASREQPYFYQFRLLEVTVKNGSRPLATAALNFFADTERQRIPQPMSP
>NC_015690.1|WP_013918892.1|5799609_5800308_+|hypothetical-protein
MLLDAIKDKVRQESYEDLKLPLDELERLTAFRPLVIQTPKEPAYVLFQAHPESYTAPVQKDGARKVVDCSLLRPAGKLETDLMLEMYRHRIYTLYAFAFMFTYEDKGLILLWSQQLEQPPTFNRTQTNALLEEALGPEGDSSYFTLSRIFHPAQLIELTYENQTISTAVGGHSFVMIIPVEKKWTLSLRRSKKVPDDDFDILRRKLALYKEEAILLQNYFHRNGLWSEKASL
>NC_015690.1|WP_013918893.1|5800388_5801846_-|DUF5050-domain-containing-protein
MLRKLNLWTAAAAAGLLMLGPITNAEAAATEAVEVAFPAFPVTVNETALDGVHSLYPLLLHKGVTYFPMTWNYTSALGLSVSWNAEDGLSLTKTEGICGPVPQTLSAELKNSGRAADAVPVPFPVTVNGKAVDSPNETYPLLLYRNITYFPMTWRFTKEEFGWQAAWDPVSGYSIQSCPVEAAAGKRLQTALNLSNGGQLAADEKWIYKNPVRNSEGPHSLVRTELNGEHPLKLSDDLAMYINASGEWLHYIAYDQSGTILKIRKDGTNRTILPATGVGELWADGEWLYYTKRTQQPESRENASSSPPGIYRMKTDGTGGVQLNPSGEVKSLYVYSDRIFYLKGEQGKEGLYSMKLDGSDDRKVQERVTDFIITEDWIYYVRDGKDLRKISLDGSIDIPLLEQEKPYMGRLSYKDGWIYFAAGATGIHGSLPLERVRLDGTGRETVFEARPTAIYWAGEAMYFAQWSLGSHVLYEHQLKEPAPKP
>NC_015690.1|WP_041617277.1|5801869_5802742_-|DUF4362-domain-containing-protein
MNRLVACFAGAAILLWGCESSEMPGKTKNVSAEVTNQHGNVENLTALDQYVQHSLEGQRGAVRIVHMTIEGDPIYNDLSFSGAGHKLRIDTTQDKFGSPKITDLTCRSMEKVESSVSMKYVLRGCSGEADERTVLHIAFDLAKQDRFEFALRYGPSAFDSQNEISTIDSRLSRDLINGSVHVAQGFEIPFEAKQRIYRALVLANYLGTKELSEGCEAAADETSAGSSSEQRNFSLKVLINGGSREFRWANCGNDSSGNTLGLTTVAEEIIREAEQTEAFRSLPPVQGARL

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_015690_20

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015690_20

6768473-6768547

Orphan

Consensus_repeat	Method
AATAGCGGAACTCCAGTGCCTTAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015690_20

>merge|NC_015690|20|6768473-6768547|CRISPRCasFinder
AATAGCGGAACTCCAGTGCCTTATCCGGTTATTTCCCGTTATTTCCCGGAGAATAACGGAACTCCAGTGCCTTAT

>NC_015690|20|14|6768473-6768547|CRISPRCasFinder
AATAGCGGAACTCCAGTGCCTTAT	CCGGTTATTTCCCGTTATTTCCCGGAG
AATAACGGAACTCCAGTGCCTTAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_015690.1\|WP_013919810.1\|6761907_6762747_+\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197666
NC_015690.1\|WP_013919820.1\|6774270_6774702_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379228
NC_015690.1\|WP_013919824.1\|6776529_6776718_-\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013919823.1\|6776110_6776506_-\|DUF5071-domain-containing-protein	unknown	unknown	gnl\|CDD\|213039
NC_015690.1\|WP_013919807.1\|6757989_6758715_+\|DUF1361-domain-containing-protein	unknown	unknown	gnl\|CDD\|369208
NC_015690.1\|WP_049819072.1\|6756209_6757823_-\|S-layer-homology-domain-containing-protein	unknown	unknown	gnl\|CDD\|119353
NC_015690.1\|WP_041617417.1\|6768797_6770534_-\|cellulase-family-glycosylhydrolase	unknown	unknown	gnl\|CDD\|365907
NC_015690.1\|WP_013919812.1\|6763648_6764242_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NC_015690.1\|WP_013919828.1\|6779176_6779848_-\|thiaminase-II	unknown	unknown	gnl\|CDD\|381701
NC_015690.1\|WP_013919813.1\|6764402_6765116_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NC_015690.1\|WP_013919815.1\|6766949_6767966_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_015690.1\|WP_013919822.1\|6775200_6776079_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293840
NC_015690.1\|WP_013919817.1\|6770653_6773083_-\|glycoside-hydrolase-family-6-protein	unknown	unknown	gnl\|CDD\|227616
NC_015690.1\|WP_041617413.1\|6762987_6763587_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
NC_015690.1\|WP_013919826.1\|6777486_6778353_-\|family-43-glycosylhydrolase	unknown	unknown	gnl\|CDD\|350095
NC_015690.1\|WP_013919808.1\|6758818_6760114_-\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|372371
NC_015690.1\|WP_013919814.1\|6765179_6766772_-\|glycoside-hydrolase-family-28-protein	unknown	unknown	gnl\|CDD\|227721
NC_015690.1\|WP_013919819.1\|6773664_6774081_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319899
NC_015690.1\|WP_013919809.1\|6760208_6761294_-\|aspartate-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|236329
NC_015690.1\|WP_013919827.1\|6778661_6779123_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181

Protein	Function_ID	Function_description	E-value
NC_015690.1\|WP_013919810.1\|6761907_6762747_+\|AraC-family-transcriptional-regulator	gnl\|CDD\|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	1.12942e-25
NC_015690.1\|WP_013919820.1\|6774270_6774702_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	2.39547e-13
NC_015690.1\|WP_013919828.1\|6779176_6779848_-\|thiaminase-II	gnl\|CDD\|381701	cd19366, TenA_C_BhTenA-like, TenA_C proteins similar to Bacillus halodurans TenA. This family of TenA proteins belongs to the TenA_C class as it has a conserved active site Cys residue; the double Glu residues identified in the active site of TenA_E from the archaeon Pyrococcus furiosus is conserved in this family. TenA_C proteins (EC 3.5.99.2) catalyze the hydrolysis of the thiamin breakdown product 4-amino-5-amino-methyl-2-methylpyrimidine (amino-HMP) to 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP) in a thiamin salvage pathway. This family includes Bacillus halodurans TenA which participates in a salvage pathway where the thiamine degradation product 2-methyl-4-formylamino-5-aminomethylpyrimidine (formylamino-HMP) is hydrolyzed first to amino-HMP by the YlmB protein, and the amino-HMP is then hydrolyzed by TenA to produce HMP. It has also been suggested that TenA proteins act as transcriptional regulators based on changes in gene-expression patterns when TenA is overexpressed in Bacillus subtilis, however this effect may be indirect.	3.9998e-133
NC_015690.1\|WP_013919823.1\|6776110_6776506_-\|DUF5071-domain-containing-protein	gnl\|CDD\|213039	cd11743, Cthe_2751_like, Uncharacterized protein domain similar to Clostridium thermocellum 2751. Cthe_2751 has been found to form homodimers. Based on structural similarity to other families, a role in processing nucleic acids was suggested, though interactions with DNA could not be demonstrated.	2.20927e-49
NC_015690.1\|WP_013919807.1\|6757989_6758715_+\|DUF1361-domain-containing-protein	gnl\|CDD\|369208	pfam07099, DUF1361, Protein of unknown function (DUF1361). This family consists of several hypothetical bacterial proteins of around 200 residues in length. The function of this family is unknown although some members are annotated as being putative integral membrane proteins.	3.5491e-30
NC_015690.1\|WP_049819072.1\|6756209_6757823_-\|S-layer-homology-domain-containing-protein	gnl\|CDD\|119353	cd02874, GH18_CFLE_spore_hydrolase, Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the forespore inner membrane and is deposited as a mature enzyme in the cortex layer of the spore. As part of a sensory mechanism capable of initiating germination, CFLE degrades a spore-specific peptidoglycan constituent called muramic-acid delta-lactam that comprises the outer cortex. CFLE has a C-terminal glycosyl hydrolase family 18 (GH18) catalytic domain as well as two N-terminal LysM peptidoglycan-binding domains. In addition to SleB, this family includes YaaH, YdhD, and YvbX from Bacillus subtilis.	5.47935e-33
NC_015690.1\|WP_041617417.1\|6768797_6770534_-\|cellulase-family-glycosylhydrolase	gnl\|CDD\|365907	pfam00150, Cellulase, Cellulase (glycosyl hydrolase family 5).	8.76149e-76
NC_015690.1\|WP_013919812.1\|6763648_6764242_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	1.68093e-15
NC_015690.1\|WP_013919813.1\|6764402_6765116_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	4.88232e-28
NC_015690.1\|WP_013919815.1\|6766949_6767966_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.51965e-112
NC_015690.1\|WP_013919822.1\|6775200_6776079_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293840	cd16282, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily.Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	2.65724e-36
NC_015690.1\|WP_013919817.1\|6770653_6773083_-\|glycoside-hydrolase-family-6-protein	gnl\|CDD\|227616	COG5297, CelA, Cellobiohydrolase A (1,4-beta-cellobiosidase A) [Carbohydrate transport and metabolism].	0
NC_015690.1\|WP_041617413.1\|6762987_6763587_+\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	9.33791e-38
NC_015690.1\|WP_013919826.1\|6777486_6778353_-\|family-43-glycosylhydrolase	gnl\|CDD\|350095	cd08981, GH43_Bt1873-like, Glycosyl hydrolase family 43 protein such as Bacteroides thetaiotaomicron BT_1873. This glycosyl hydrolase family 43 (GH43) subfamily includes Bacteroides thetaiotaomicron VPI-5482 endo-arabinase (Bt1873;BT_1873), as well as uncharacterized enzymes similar to those with beta-1,4-xylosidase (xylan 1,4-beta-xylosidase; EC 3.2.1.37), beta-1,3-xylosidase (EC 3.2.1.-), alpha-L-arabinofuranosidase (EC 3.2.1.55), arabinanase (EC 3.2.1.99), xylanase (EC 3.2.1.8), endo-alpha-L-arabinanase and galactan 1,3-beta-galactosidase (EC 3.2.1.145) activities. These are inverting enzymes (i.e. they invert the stereochemistry of the anomeric carbon atom of the substrate) that have an aspartate as the catalytic general base, a glutamate as the catalytic general acid and another aspartate that is responsible for pKa modulation and orienting the catalytic acid. Many of the GH43 enzymes in this family may display both alpha-L-arabinofuranosidase and beta-D-xylosidase activity using aryl-glycosides as substrates. A common structural feature of GH43 enzymes is a 5-bladed beta-propeller domain that contains the catalytic acid and catalytic base. A long V-shaped groove, partially enclosed at one end, forms a single extended substrate-binding surface across the face of the propeller.	5.78718e-178
NC_015690.1\|WP_013919808.1\|6758818_6760114_-\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|372371	pfam12897, Aminotran_MocR, Alanine-glyoxylate amino-transferase. These proteins catalyze the reversible transfer of an amino group from the amino acid substrate to an acceptor alpha-keto acid. They require pyridoxal 5'-phosphate (PLP) as a cofactor to catalyze this reaction. Trans-amination reactions are of central importance in amino acid metabolism and in links to carbohydrate and fat metabolism. This class of aminotransferases acts as dimers in a head-to-tail configuration.	0
NC_015690.1\|WP_013919814.1\|6765179_6766772_-\|glycoside-hydrolase-family-28-protein	gnl\|CDD\|227721	COG5434, PGU1, Endopygalactorunase [Cell envelope biogenesis, outer membrane].	7.3258e-86
NC_015690.1\|WP_013919819.1\|6773664_6774081_-\|VOC-family-protein	gnl\|CDD\|319899	cd06588, PhnB_like, Escherichia coli PhnB and similar proteins. The Escherichia coli phnB gene is found next to an operon of fourteen genes (phnC-to-phnP) related to the cleavage of carbon-phosphorus (C-P) bonds in unactivated alkylphosphonates, supporting bacterial growth on alkylphosphonates as the sole phosphorus source. It was originally considered part of that operon. PhnB appears to play no direct catalytic role in the usage of alkylphosphonate. Although many of the proteins in this family have been annotated as 3-demethylubiquinone-9 3-methyltransferase enzymes by automatic annotation programs, the experimental evidence for this assignment is lacking. In Escherichia coli, the gene coding 3-demethylubiquinone-9 3-methyltransferase enzyme is ubiG, which belongs to the AdoMet-MTase protein family. PhnB-like proteins adopt a structural fold similar to bleomycin resistance proteins, glyoxalase I, and type I extradiol dioxygenases.	5.31191e-31
NC_015690.1\|WP_013919809.1\|6760208_6761294_-\|aspartate-semialdehyde-dehydrogenase	gnl\|CDD\|236329	PRK08664, PRK08664, aspartate-semialdehyde dehydrogenase; Reviewed.	0
NC_015690.1\|WP_013919827.1\|6778661_6779123_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	8.11701e-10

>NC_015690.1|WP_013919815.1|6766949_6767966_-|LacI-family-DNA-binding-transcriptional-regulator
MKATIYDVAREAGVSIATVSNAIRGKGKISPKKREEILEIVERLQYQPSMIASALTGKRTYTLGLLVPDISNPFFGEIARAVEERGQQLGYSVIICSTDNKDERVERYISLLEQKSVDGIIIGTGISDASLLERLSSRSVPVAMIARDLPSADVHKVVIDDYLGGVLAARHLLELGHRRFGVISEKHNRERIRGFCETVERSGQALSPCGIRIFGDDDQIQDGGRAAAELLELEARPTALFCCNDMSATGALRAAKARGLAVPRDISIVSFDNTILSEVCDPPMTTIAQPMEEMGRLVVDALLQELGDGGAKQRFVLQPELLVRGSTAAFVPEEQKNA
>NC_015690.1|WP_013919814.1|6765179_6766772_-|glycoside-hydrolase-family-28-protein
MSSIEPIVSGSSWTLSEVRQPSIPDRSFSVTDYGAVGDGVTDNTEAFHKAIAACSQAGGGRVVIPAGVWLTGPLSLASRLDLHAQAGALVLFSRRFEDYPMIFSQYEGQPSIRCQSPLDGEGLEHVAITGAGVFDGGGDAWRPVKDWKMTEKHWAKLIASGGVVDEAAGMWWPSEAAMNGPAKVAQLKREGSTDPKDYEAARDYLRPNLLSLRRCKYVLLEGATFQNSPAWNLHPWACEHVTLRGVTVRNPWYGQNGDGLDLDSCRYGLVEDCSFDVGDDAICIKSGKDEAGRELGIPCEDILIRNCRVYHGHGGFVIGSEMSGGVRRLRVEDCTFMGTDIGLRFKSTRGRGGLVEDIEIERIRMNSIVGEAISFHLFYEGKEGSGVAGENIVPVSVETPIFRGITIRDVQCAGAETALLINGLPEMPLDGLVVENFTASAKRGVVCTNAQNLTLKDVTLHVEQGPVVSLRHAQHVKIEVLGGSAPEGSDMLQVSGRGSKEIAYGGIRLPEELRGVKIAVEVEDKNSIRG
>NC_015690.1|WP_013919813.1|6764402_6765116_+|alpha/beta-hydrolase
MQMQMQTQVKQVELNGLLFQYRETGKISSPPIIALHAMGMTAETWDEAAAVLGETHRVLALDQRGHGGSARTGSYTFELMCEDVLAFADRMGLERFILLGHSMGGTVSYLFSQTYPSRVERLLVEDTPPPFAGKRFDIPPEPSEPLPFDWAVVPSIIGQLNEPDPQWWARLPAIQAPTLIIGGGVSSPIPQDKLKEVSGLIPICKLVTVDGGGHHVHSTRLPAFLAAVQSFLKDEPV
>NC_015690.1|WP_013919812.1|6763648_6764242_-|TetR/AcrR-family-transcriptional-regulator
MPRTPQENERIRGMAKEKIRAAAIEVFIEKGFHKASIDDVAKKAGISKGLLYNYFKGKTDLLAELVHTRKEEIVQVMEEAVRQASPKEQLLYIAEHALRSVERQPHVYRFYLHLQTHPEADEVVSAYSQTLKDEMARQAEVQAEIFRNLNAARPELESLQFSTMLHGIMLMYSSYPNGFPLEELKHDMVTSFINRYA
>NC_015690.1|WP_041617413.1|6762987_6763587_+|histidine-phosphatase-family-protein
MAAELYLVRHAKKEKGIGDAAISSEGMRQAQATARHFRGLPITQILCSPLQRAKMTAAIIAKGTGTVLTEDHRLRERANWGDIPGQTFEDFVEMWDRCTLDRDFSPPAGDSARQAGERLASCLLDLSATHPQGPLLVVTHGGLITDFLVQVIPEAELNKLHPRFIAEQSRLVAECSITTVRCEDGRFSLVDFAAVEHLL
>NC_015690.1|WP_013919810.1|6761907_6762747_+|AraC-family-transcriptional-regulator
MTERTGFKYTIGDTAFAIQQLQQTGVTSMPRPHSHEFYELYYLFHGERVYFIGGKVYTARKGDLMVVVPNDLHSTASSAVAEFERMLVHFSPSFLGEEGPGLMELPPFRESTLLSIPMKEQPELEHLLLQLHTECREQQPLYEACVRHLLGELLVRIHRRGLIEQEPPESVHPMHQKVTEIASYIHGHYQEDLTLGGVAKQFFISPAYLSRVFLKLTGFHFSEYIRVVRVREAQKLLRTTREKVQSISEQVGFEHISHFNKTFKRIAGLSPLQYRDQHR
>NC_015690.1|WP_013919809.1|6760208_6761294_-|aspartate-semialdehyde-dehydrogenase
MSAKLKVGIVGGTGMVGQRFMQLLDQHPWFEVTAIAASAGSAGKTYEESVQGRWKMDGPIPEEVKSIVVQDASKVEEVASGVDFIFCAVDMKKAEIQALEEAYAKTGTPVISNNSAHRWTPDIPMVIPEVNPGHIEIIEAQRKRLGTSTGFIAVKPNCSIQSYVPALNALLDYQPKVVVASTYQAISGAGKNFTDWPDMLDNVIPYIGGEEEKSEQEPLRIWGSIQGGEIVKASAPLITTQCIRVPVTDGHMATVFASFEKKPAKDEILDRWRTFKGRPQELGLPSAPEQFITYFEEDNRPQTKLDRDIYGGMGVSVGRLREDTVYDYKFVGLSHNTLRGAAGGAVLIAELLKAEGYIQAK
>NC_015690.1|WP_013919808.1|6758818_6760114_-|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme
MESQPAFVHWESEELRDHHRRLTQRYEACRSQKMALDMSRGKPCPEQLELSREMLGIVAADDPLRAADGSDCLNYGGIDGIPEAQSLFARMLGVESKEILIGGNSSLTMMHDALTRAMLHGVYGSERPWGRLPKVKFLCPSPGYDRHFAICELLQIEMIVVDMLPSGPDMDQVERLVREDDSIKGIWCVPKYSNPDGITYSDAVVDRLSQMKTAAADFRIFWDDAYTVHHLTPEPDVLKNILAACRAAGNPDRVFLFCSTSKITFPGAGVAVLASSENNLGLIRRQLAVQTIGPDKINQLRHVRFLRDMDHLKTHMERHAAIIKPKFDLVLRKLEEELADKQIASWHKPNGGYFISLNTLDGCADEVVRMAAEAGVTLTKAGATFPYGKDPRNRNIRIAPTYPSLTELETAIDILCLCVQIVSVRKMLSER
>NC_015690.1|WP_013919807.1|6757989_6758715_+|DUF1361-domain-containing-protein
MEGTIMNLNRLLPWVPLLTLLSLVTAACLLLSSRLGEAYDFLRWDVTLAWIPVPLALLFLSLDGLASRWVRYGLRAVVGPLWLAFFPNSAYLVTELLHAFRFFEMQPGFWTGIDYWYRVMPIFGVACLGLALSTSSLYLLHRWTSARLGALTGWFFAAAALALASFGVYIGRILRWNSWDLAARPRMIVTELAALYQDTSRWSHAVSFVELFFAVLFLSYGIFYTAIVLGAKGSPAPASLQ
>NC_015690.1|WP_049819072.1|6756209_6757823_-|S-layer-homology-domain-containing-protein
MTLLSLIQKTIPAAALLLLAATGSALAYDVSLKPFTDVSNGDWFQEEVYSLSAIGLIDGYPDATFQPDGMLTREAFLKLLVQSKRFDPAVPPGDAPADVGPSRWSYPYIAAAYERKWIDVLLDSRRALDPQRTITRGEVAAVAGRALLDAQPQEARERWMSQGWQEERERRKYTDGDTIGEGLRPYAYYAVNRGIMEGDETGFHPQQPLTRKEAAAIFYRLIDAETAGAKLEHTGFYAIRSYPAIGRIPLLSQVTFGWSHLEYPSPGTARLNTEKTEYRIPSGWEEALGAAGSAKAGKELMVYYGDKNLKDFLKDEGAQNAFIDSLKAVLTDKKYGFSGVCMDLEGLLEPASAADYVQFLHRVKKSIPDYKLTVAVQPDYYYKGYDLKEIGGLADTVILMAYNFTHDESRLPSAPLPLVNDSVKRALALVPKEKLVLGISKQANQWVTAPDGGTDSFNPEIAEVEKRLGAPGVSQSMSYPYFLKRMAFQDERGSHEMYYEDTESIEKKLWLAKYYGLKGVSLWYMGNYTDSDWKLFE
>NC_015690.1|WP_041617417.1|6768797_6770534_-|cellulase-family-glycosylhydrolase
MKPFRLWGAWLSTAVAVLGLMLPFGAAYSQAAAAVPYGQLKVQGADLLGESGQRVQLRGMSSHGIHWYGDLVNPGSLKWLKEDWNSNLFRVAMYTAEKGYITDPSVKEKVKEAVQAAIDLGLYVIIDWHILTDGDPNTYKTQAKAFFQEMAALYGQYPNVIYELCNEPNGNVTWAGQIKPYAQELTQAIRAIDPDNIIIVGTPNWSQDVNQAADSPLPYGNIMYAAHFYAGTHGQWLRDKIDYARSKGAAVFVTEWGASDASGDGGPFLREAQEWIDFMNSRGISWANWSLADKEETSAALLPGANPSGGWPASQLSASGQFVRSKLRESLVSVPAAPAGLQAAPGSGQAALSWNAVNGATGYIVNRAAVSGGPYTTVAELTGTSYTDTGLANGTTCYYVVSAKNAAGTGPASAQVSVQPAAGQGGGTPVPGSLVLQYRAADTNAGDNAIKPHFNIRNTGASPVDLSGVKLRYYFTKDGTQPLSFTVDWAQVGSPNVKGTFGSASGAGADTYLEVSFTGGSIPAGGQTGEIQTRIHKSDWSSFQESGDYSYDPGKTSYADWSKVTLYRDGTRVWGVEP
>NC_015690.1|WP_013919817.1|6770653_6773083_-|glycoside-hydrolase-family-6-protein
MRNSVWRKMSSVLAAAALLGGLLPAGAATSYAAEAHVDNPFAGATAYVNPDYAAQIDTSIAKVSDPALQAKMETLKSYPTAVWLDRIAAIGGGASNGGRRSLEGHLDAALAQKKGTAPITATFVIYDLPGRDCHALASNGELPLTQEGLQRYKTEYIDAIASIFANPKYRDIRIVTVIEPDGLPNLVTNLSDPKCAAANSSGIYIAGFQYALNKLHAIPNVYNYLDIGHSGWLGWDDNRRGAVTLYTNAVKGTTAGLASVDGFITNTANTTPLVEPYLTNPNLSINGQPIRSSKYYEWNPNFDETDFTAALYADFTAAGWPSTLGFLVDTGRNGWGGVNRPAGASGSDIDTYVNSGRIDRRAHRGLWCNNNGAGIGLPPQNAPAGYAASHIDALVWVKPPGESDGASKFIPNDEGKLADPNCDPTYTNADGVLTGAMPDAPLAGHWFHDQFVMLVQNAYPAIPGSGGGTPAVPAAPVGVKAAEGNAQVTLTWDASAGAASYTVKRASVSGGPYTTVAAGLTATSFTNTGLTNGTVYYYIVTASNAAGESAASVQVSAVPSSGVSVPAAPAGLTAAAGNAQVTLTWSASAGATSYTVKRATVSGGPYTTVATGLAATSYTNTGLTNGTAYYYVVSAVNSAGESANSAPVSAVPEGSVTPPAGSLAVQYRAGNTNAADNAISPHFNIKNNGTAAVNLSDLKIRYYFTKDGSAGLDSWVDWAQVGGANVQRVFSSASGTGADTYVEISFTAAAGSIPAGGQTGDIQLRMAKTDWSNFNETGDYSFDGTKTAYANWDKVTLYQGGKLVWGIEP
>NC_015690.1|WP_013919819.1|6773664_6774081_-|VOC-family-protein
MAKHNTYFFSEDARAQADFYVQALGGEIQAVMTNGQLPEAAEGTKDKVIHLSMVAAGVNFCLADAEYGPVSSGNAVSQCLTFATEAEAREAFEKLSEGGTVSQPLEPAFWGALFGQLEDKFGVQWMITTESQECQTPA
>NC_015690.1|WP_013919820.1|6774270_6774702_+|GNAT-family-N-acetyltransferase
METTYKQYVISDDPSKIQVETVVEFLAGSYWANLRQPERIRASIRSSVCYGVYDGDRMVGFARVVTDGAAVYYVCDVFVLEAYRGQGISKKLVELITNAPEFEWMTGILGTRDAHGLYEQFGFQRDAQAYMKRLPQARRGEGE
>NC_015690.1|WP_013919822.1|6775200_6776079_-|MBL-fold-metallo-hydrolase
MQTIEKVGERFWYQTPVSETDRPILGMVVGRERRLMIDAGNSEAHARYFLEELEERGIGAPDLAVLTHWHWDHIFGLEWLHQHAVSIASSGTREAMEKLMPLSWSDEALDRRVEEGTEIEFCASAIKKEFPLHRDIRIALPVMTFENRMELDLGGITCVLQHVGGDHAGDSVVVYIPEEKILFLGDCIYADIFSAKRNYTPGKTLALLEVLETFDAETYVLSHWKPVSKAEFREEAALLRTMAQLTDEFAGDSARMREAYEKRKGRGLTEEELETLEYFVNGVALQKKTSMT
>NC_015690.1|WP_013919823.1|6776110_6776506_-|DUF5071-domain-containing-protein
MDHLREYLPKDKHDFESVAVLKGLEREKITELIPNLLEWLRDMNWPIAAEIARLLLRYPEEVIPHLWMVLRSGDEIWKYWCLEYLVGELPRIHFLVFKEELERIANQPTRGEELEEVHSAARRVLEFFGTN
>NC_015690.1|WP_013919824.1|6776529_6776718_-|hypothetical-protein
MFLIDLFPLMIGLYCVTLALWELREGHDRKRFVTLMFSGLVLVFVVPRLLGVGAGLFLTGFH
>NC_015690.1|WP_013919826.1|6777486_6778353_-|family-43-glycosylhydrolase
MLRRDEIRIRDPFVVPVQNEGLYYLYGTTDENVWQGPGVGFDVFRSRDLESWEGPFPAFRPEPGFWADRHFWAPEVHLYEGRYYMFASFKSEERSRGTQILASDSPLGPFVPLTGGPVTPAGWECLDGTLYLDEEGAPWMIFCREWLQVHDGEMYAVRLTRDLRGTEGEPLLLFRASEAPWTRHAREETDYVTDGPFLHRTESGELVMLWSSIGDKGYAIGLARSASGRIEGPWVHDADRLLEEDGGHGMLFRAFGGEWMLTIHAPNRTPNERPVFYPVKELRASGLQ
>NC_015690.1|WP_013919827.1|6778661_6779123_+|GNAT-family-N-acetyltransferase
MIVRLDLTDPETARNLLKVQIPSYLVEAELIGFHGIPALNDTVESLAQSGETFYGYFAGGELAGAAAYELDGGTMEITRLVVHPKFFRRGIGGSLIRFLLELNLGVKGYRVSTGAKNGPAKRLYTNCGFKEAGELEVAPEVFLTLLERGGAGQ
>NC_015690.1|WP_013919828.1|6779176_6779848_-|thiaminase-II
MTFTQRLLGKLEGVWRQNHSHPFVREMGAGTLDRDKFRFYMIQDYLYLIDYAKLFALGAVKANDLATMEKFAALLHSTLHEEMALHRAYAARFGISEEELETAEPSPITLAYSHYMLHAAQNGSLAELVAALLPCMWSYWEIGKELSRIPGAADHEDYGEWIRMYSSEEFGALAQWCIGLLDELAEGRSEAELARLEEIFLNTTRYEYMFWDMAYHGQMWPAG

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Crispr_ID: NC_015690_21

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015690_21

6823541-6823615

Orphan

Consensus_repeat	Method
AATAGCGAACCTCAGTTCCGCTAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015690_21

>merge|NC_015690|21|6823541-6823615|CRISPRCasFinder
AATAGCGAACCTCAGTTCCGCTATCTCCTGAATAGGTCCTTCGAGCGGCAGAATAGCGAACCTCAGTTCCGCTAT

>NC_015690|21|15|6823541-6823615|CRISPRCasFinder
AATAGCGAACCTCAGTTCCGCTAT	CTCCTGAATAGGTCCTTCGAGCGGCAG
AATAGCGAACCTCAGTTCCGCTAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_015690.1\|WP_013919879.1\|6836753_6837722_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|369561
NC_015690.1\|WP_013919876.1\|6834373_6835156_+\|amino-acid-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270217
NC_015690.1\|WP_013919862.1\|6817553_6818000_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NC_015690.1\|WP_014371816.1\|6819434_6819626_+\|YqaE/Pmp3-family-membrane-protein	unknown	unknown	gnl\|CDD\|376592
NC_015690.1\|WP_013919859.1\|6815626_6816328_-\|rhamnogalacturonan-acetylesterase	unknown	unknown	gnl\|CDD\|238859
NC_015690.1\|WP_041617423.1\|6837830_6838544_-\|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|336781
NC_015690.1\|WP_013919860.1\|6816514_6817393_+\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NC_015690.1\|WP_013919874.1\|6829789_6833629_+\|family-43-glycosylhydrolase	unknown	unknown	gnl\|CDD\|350138
NC_015690.1\|WP_041617422.1\|6818821_6819325_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372952
NC_015690.1\|WP_014371818.1\|6823711_6825427_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_015690.1\|WP_013919866.1\|6819703_6820594_-\|aminoglycoside-6-adenylyltransferase	unknown	unknown	gnl\|CDD\|377357
NC_015690.1\|WP_013919868.1\|6821055_6822027_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235571
NC_015690.1\|WP_013919867.1\|6820629_6821022_-\|immunity-22-family-protein	unknown	unknown	gnl\|CDD\|379476
NC_015690.1\|WP_013919863.1\|6818026_6818584_-\|DUF1700-domain-containing-protein	unknown	unknown	gnl\|CDD\|227053
NC_015690.1\|WP_013919873.1\|6827006_6829793_+\|family-43-glycosylhydrolase	unknown	unknown	gnl\|CDD\|350130
NC_015690.1\|WP_013919877.1\|6835232_6835892_+\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836
NC_015690.1\|WP_013919872.1\|6825635_6826718_-\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NC_015690.1\|WP_187296796.1\|6835912_6836653_+\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
NC_015690.1\|WP_013919869.1\|6822244_6823204_-\|D-2-hydroxyacid-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|240646
NC_015690.1\|WP_014371821.1\|6833770_6833962_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_015690.1\|WP_013919876.1\|6834373_6835156_+\|amino-acid-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270217	cd00996, PBP2_AatB_like, Polar amino acids-binding domain of ATP-binding cassette transporter-like systems that belong to the type 2 periplasmic binding fold protein superfamily. This subfamily includes periplasmic binding domain of ATP-binding cassette transporter-like systems that serve as initial receptors in the ABC transport of amino acids and their derivatives in eubacteria. After binding their ligand with high affinity, they interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically-located ATPase. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The Abp proteins belong to the PBPI superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	3.38609e-118
NC_015690.1\|WP_013919862.1\|6817553_6818000_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	6.67972e-08
NC_015690.1\|WP_014371816.1\|6819434_6819626_+\|YqaE/Pmp3-family-membrane-protein	gnl\|CDD\|376592	pfam01679, Pmp3, Proteolipid membrane potential modulator. Pmp3 is an evolutionarily conserved proteolipid in the plasma membrane which, in S. pombe, is transcriptionally regulated by the Spc1 stress MAPK (mitogen-activated protein kinases) pathway. It functions to modulate the membrane potential, particularly to resist high cellular cation concentration. In eukaryotic organisms, stress-activated mitogen-activated protein kinases play crucial roles in transmitting environmental signals that will regulate gene expression for allowing the cell to adapt to cellular stress. Pmp3-like proteins are highly conserved in bacteria, yeast, nematode and plants.	7.66444e-12
NC_015690.1\|WP_013919859.1\|6815626_6816328_-\|rhamnogalacturonan-acetylesterase	gnl\|CDD\|238859	cd01821, Rhamnogalacturan_acetylesterase_like, Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are highly branched regions in pectic polysaccharides, consisting of repeating -(1,2)-L-Rha-(1,4)-D-GalUA disaccharide units, with many rhamnose residues substituted by neutral oligosaccharides such as arabinans, galactans and arabinogalactans. Extracellular enzymes participating in the degradation of plant cell wall polymers, such as Rhamnogalacturonan acetylesterase, would typically be found in saprophytic and plant pathogenic fungi and bacteria.	4.99502e-90
NC_015690.1\|WP_041617423.1\|6837830_6838544_-\|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein	gnl\|CDD\|336781	pfam07722, Peptidase_C26, Peptidase C26. These peptidases have gamma-glutamyl hydrolase activity; that is they catalyze the cleavage of the gamma-glutamyl bond in poly-gamma-glutamyl substrates. They are structurally related to pfam00117, but contain extensions in four loops and at the C-terminus.	1.09996e-79
NC_015690.1\|WP_013919860.1\|6816514_6817393_+\|AraC-family-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	2.08143e-27
NC_015690.1\|WP_013919874.1\|6829789_6833629_+\|family-43-glycosylhydrolase	gnl\|CDD\|350138	cd18817, GH43f_LbAraf43-like, Glycosyl hydrolase family 43 such as Lactobacillus brevis alpha-L-arabinofuranosidase LbAraf43. This glycosyl hydrolase family 43 (GH43) subgroup includes characterized enzymes with alpha-L-arabinofuranosidase (EC 3.2.1.55) activity. It belongs to the glycosyl hydrolase clan F (according to carbohydrate-active enzymes database (CAZY)) which includes family 43 (GH43) and 62 (GH62) families. GH43 are inverting enzymes (i.e. they invert the stereochemistry of the anomeric carbon atom of the substrate) that have an aspartate as the catalytic general base, a glutamate as the catalytic general acid and another aspartate that is responsible for pKa modulation and orienting the catalytic acid. Many GH43 enzymes display both alpha-L-arabinofuranosidase and beta-D-xylosidase activity using aryl-glycosides as substrates. Characterized enzymes belonging to this subgroup include Lactobacillus brevis (LbAraf43) and Weissella sp (WAraf43) which show activity with similar catalytic efficiency on 1,5-alpha-L-arabinooligosaccharides with a degree of polymerization (DP) of 2-3; size is limited by an extended loop at the entrance to the active site. A common structural feature of GH43 enzymes is a 5-bladed beta-propeller domain that contains the catalytic acid and catalytic base. A long V-shaped groove, partially enclosed at one end, forms a single extended substrate-binding surface across the face of the propeller.	2.76697e-168
NC_015690.1\|WP_041617422.1\|6818821_6819325_+\|hypothetical-protein	gnl\|CDD\|372952	pfam14184, YrvL, Regulatory protein YrvL. YrvL prevents expression and activity of the YrvI sigma factor. It may function as an anti-sigma factor.	2.29913e-25
NC_015690.1\|WP_014371818.1\|6823711_6825427_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	0
NC_015690.1\|WP_013919866.1\|6819703_6820594_-\|aminoglycoside-6-adenylyltransferase	gnl\|CDD\|377357	pfam04439, Adenyl_transf, Streptomycin adenylyltransferase. Also known as Aminoglycoside 6- adenylyltransferase (EC:2.7.7.-), this protein confers resistance to aminoglycoside antibiotics.	1.54184e-167
NC_015690.1\|WP_013919868.1\|6821055_6822027_-\|hypothetical-protein	gnl\|CDD\|235571	PRK05704, PRK05704, 2-oxoglutarate dehydrogenase complex dihydrolipoyllysine-residue succinyltransferase.	0.00202153
NC_015690.1\|WP_013919867.1\|6820629_6821022_-\|immunity-22-family-protein	gnl\|CDD\|379476	pfam14112, DUF4284, Immunity protein 22. A predicted immunity protein with an alpha+beta fold and conserved tryptophan,tyrosine and an acidic residues. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, which usually contains toxin domains of the ColD/E5, Tox-REase-4, Ntox49 or Ntox14 families. The domain is also found in heterogeneous polyimmunity loci.	1.76904e-35
NC_015690.1\|WP_013919863.1\|6818026_6818584_-\|DUF1700-domain-containing-protein	gnl\|CDD\|227053	COG4709, COG4709, Predicted membrane protein [Function unknown].	3.13158e-08
NC_015690.1\|WP_013919873.1\|6827006_6829793_+\|family-43-glycosylhydrolase	gnl\|CDD\|350130	cd18618, GH43_Xsa43E-like, Glycosyl hydrolase family 43, including Butyrivibrio proteoclasticus arabinofuranosidase Xsa43E. This glycosyl hydrolase family 43 (GH43) subgroup belongs to the GH43_AXH-like subgroup which includes enzymes that have been characterized with beta-xylosidase (EC 3.2.1.37), alpha-L-arabinofuranosidase (EC 3.2.1.55), alpha-1,2-L-arabinofuranosidase 43A (arabinan-specific; EC 3.2.1.-), endo-alpha-L-arabinanase as well as arabinoxylan arabinofuranohydrolase (AXH) activities. GH43 are inverting enzymes (i.e. they invert the stereochemistry of the anomeric carbon atom of the substrate) that have an aspartate as the catalytic general base, a glutamate as the catalytic general acid and another aspartate that is responsible for pKa modulation and orienting the catalytic acid. Many GH43 enzymes display both alpha-L-arabinofuranosidase and beta-D-xylosidase activity using aryl-glycosides as substrates. AXHs specifically hydrolyze the glycosidic bond between arabinofuranosyl substituents and xylopyranosyl backbone residues of arabinoxylan. This subgroup includes Cellvibrio japonicus arabinan-specific alpha-1,2-arabinofuranosidase, CjAbf43A, which confers its specificity by a surface cleft that is complementary to the helical backbone of the polysaccharide, and Butyrivibrio proteoclasticus GH43 enzyme Xsa43E, also an arabinofuranosidase, which has been shown to cleave arabinose side chains from short segments of xylan. Several of these enzymes also contain carbohydrate binding modules (CBMs) that bind cellulose or xylan. A common structural feature of GH43 enzymes is a 5-bladed beta-propeller domain that contains the catalytic acid and catalytic base. A long V-shaped groove, partially enclosed at one end, forms a single extended substrate-binding surface across the face of the propeller.	2.09862e-150
NC_015690.1\|WP_013919877.1\|6835232_6835892_+\|amino-acid-ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	4.00872e-68
NC_015690.1\|WP_013919872.1\|6825635_6826718_-\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	4.07822e-51
NC_015690.1\|WP_013919879.1\|6836753_6837722_-\|alpha/beta-hydrolase	gnl\|CDD\|369561	pfam07859, Abhydrolase_3, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	1.67384e-90
NC_015690.1\|WP_013919869.1\|6822244_6823204_-\|D-2-hydroxyacid-dehydrogenase-family-protein	gnl\|CDD\|240646	cd12169, PGDH_like_1, Putative D-3-Phosphoglycerate Dehydrogenases. Phosphoglycerate dehydrogenases (PGDHs) catalyze the initial step in the biosynthesis of L-serine from D-3-phosphoglycerate. PGDHs come in 3 distinct structural forms, with this first group being related to 2-hydroxy acid dehydrogenases, sharing structural similarity to formate and glycerate dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily, which also include groups such as L-alanine dehydrogenase and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. Many, not all, members of this family are dimeric.	0
NC_015690.1\|WP_187296796.1\|6835912_6836653_+\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	8.00655e-141

>NC_015690.1|WP_013919869.1|6822244_6823204_-|D-2-hydroxyacid-dehydrogenase-family-protein
MKLRCAVLDDYQRAAASLADWSSLEDRVEVEFFHEHEDDEDKLAAALERFEIIVIMRERTPFRASLLGRLPRLKLLVTTGMRNASVDLAAAAGQGVAVCGTRGNPEPTPELTWALILGLARRLVPEHQALRSNGPWQSTLGIDLYGKRLGLLGLGTVGSRVARVGLAFGMEVAAWSPNLTAERAAEVGVQLAASKEELLESSDFVSVHLVLGDRSRGLLGREELKRMRPTAYLINTSRAPIVDREALVEALQEGWIAGAGVDVYDREPLPADDVFRTLPNVLTTPHLGYVTERNYRTFYGDAVEDIRAFLAGEPVRKLN
>NC_015690.1|WP_013919868.1|6821055_6822027_-|hypothetical-protein
MHRTWIIVLVGGIAAAAGLSLLGSAREELAPTPGSASPALGTEAHSPEHDGGPASKPGLVITQIAEGQTVVLDTAGGRPTRETGGEAGPSEPAGPSQEAVPPETAVPGQEALSSEPAAAGHEALPLLEPAAPGIAAGTVVGEGKADADGDGRTDTVRIRMTEGEERTDPNPGAFEGTHLHGTFEAVAETSDGRELSRFPLNGAFGGGEMIFRKGEPFRLLFDDYNDDGRPDFTVGQWGGSNGNFYVLLTIGPEGFQVLAKEIYSADHRESIRYRRTGKLAFRNIYYDQTRGAYMEVIRRWKDGAFAAEAPREIQDVGSAGVDP
>NC_015690.1|WP_013919867.1|6820629_6821022_-|immunity-22-family-protein
MDKDLTDGSRVSLWLGSWSSEEAAKAYVEGSYTEDGDYVPSPFERDFAFRYDPDFIELNFKETPAADWESLLQGHSYDEEIIPAFMEEIGPLSRSFNTVILVYNLAYDAEHLRSGTAAGELEYIGQAAYD
>NC_015690.1|WP_013919866.1|6819703_6820594_-|aminoglycoside-6-adenylyltransferase
MRSEREMMDTILSFANEEEGIRAVIMNGSRVNPKARRDPFQDYDIVFFVRQVGPFVRDRSWIRRFGGMMIMQTPDEMETEPDVTGEYSRFAFLMQFADGNRIDLTLIPYERRDKLPGDSLSVLLLDKDGTLEPYPPPSDRDYLTQPPAPQSFAACCNEFWWVSTYVAKGLWRRELPYAKTMMEGPVRSMLVRMLEWHVGIHSGFTAATGKAGKHLEKHLAPKLWEAYVGTYADGDYDRIWEAMFVMGGLFRETAQDVASHFGYAYPEEDDRRVTAHLHYVRALPEDAVELYGEADG
>NC_015690.1|WP_014371816.1|6819434_6819626_+|YqaE/Pmp3-family-membrane-protein
MMYLLAILLPPVAVLLSGKPFQAFLNLILTLCFWLPGAIHACMVVHEKKQDRRMERLQRGLYK
>NC_015690.1|WP_041617422.1|6818821_6819325_+|hypothetical-protein
MSDSGKTPGTPPEEPMSFKDKTLAVSVFALFLVFVLIFVLAAVFFLFTGTFHLLGIEYDSWRSVFVFIGAGLVSDLVLGLLLLFPKVLCTLYFARSPRWQLFLFLLLLQFTFDLISVHYIDEWMDGVTIGSGAEAAFVLIMLALDKLIPDRKKEKGKWAQGPPQGRF
>NC_015690.1|WP_013919863.1|6818026_6818584_-|DUF1700-domain-containing-protein
MSPERKQFLSLVSQHLSGLPEGERSEAVRKADRQIDHAVRSGLTEQAALIRLGDPKVIAEEYRGQARKSKRGARSFKGVLRLIGFCCTTGLLTAIVVPFLAALAYGFGISSILIFAAGLLRTFGVPWIPLNLGPGLAIPAEYSMAATLIGGVVTGWIGYASGGVLKKYLAFLSASYRRVQPGQSC
>NC_015690.1|WP_013919862.1|6817553_6818000_+|GNAT-family-N-acetyltransferase
MSLLIRCAEHQDLLPLSGLMHDYIVGFYRNPWPGDDRIHNLIRSLLERQAGVQFVAEREGALIGFATLYFTYSTMKANPITIMNDFFLLEPYRGTEAQTRLFAHCRSFSLDNGFSYMSWITGTGNERAQHFFDEAGALRGSWVNYSIV
>NC_015690.1|WP_013919860.1|6816514_6817393_+|AraC-family-transcriptional-regulator
MNDVYSQKYTLENEAFAIQYMNYRGYFKMPRDHLHSYYEIFYLLEGERVYFINDTVYTAQKGDLVIVNPYDLHHTSSSDVPGFERMLINFTPEFALPLFAGSPPKLLPFAQGSKLLRLPLKEQTAAEGLIRQMYSECAEAHPGYETCVKAALAQLLVRIHREFLRESRSPAPTEYTHPMHEKISEIAAYLTRHYAEELTLEGVAAQFFISPSYLSRVFKKITGYHFREYLLQIRVKEAQRRLRETRDKTISIAEQTGFRHISHFNTTFKKIVGLPPLQYRKQQQELHQKRLP
>NC_015690.1|WP_013919859.1|6815626_6816328_-|rhamnogalacturonan-acetylesterase
MREDKRVTVYIAGDSTAANYPEDKRPMSGWGEWIASYLAEEVRVSNRARNGRSSKSFIAEGHFDLIASSIGEGDYLLVQFGHNDEKPDEKRHTDPGSTYEENLTRYIEMARSKGAHPLLLTSVERRKFNEAGELVPSHGDYPAAVQRLAEKLEVPLLDLCSRTQEAYRKLGAEASKAWFVWLEPGEHPNYPEGERDDTHFNELGAQKVAGLVAEALAASGSPLAGYLKAGAVG
>NC_015690.1|WP_014371818.1|6823711_6825427_-|ABC-transporter-ATP-binding-protein
MLRRFFSYYRPYRGLFLLDFGCAVVAGLLELGFPLAVNQFVDKLLPGQNWPLILWACAALLFIYVLNTALQYVVTYWGHMLGINIETDMRRKLFDHIQKLSFRFFDNNKTGHLMTRITNDLNEIGEIAHHGPEDIFIAVMTLLGAFGLMLTINWKLAVLTFVIIPLMAWFALHFSSRMTRTYERLFGDVGEFNTRVENNIGGIRVVQAFANEEYEKELFKVNNQQYRLTKLLAYKLMAKSMSITYMMMRLVSVFVMIAGTWFVIRGELSYGEFVGFLLLSNVFFRPIEKINAVIESYPKGIAGFKRYCAILDTEPDVADAPDAVAAGPLNGDIVFRSVSFGYDGSKQILKGLNLSIRAGETVAFVGPSGAGKTTICSLLPRFYECSEGSITIDGMDIRRMTLQSLRSQIGIVQQEVYLFEGTIRQNIAYGKLDAGDEEIWEAARRAQLEEFIRKQPDGMQTQIGERGVKLSGGQKQRLAIARMFLKNPPILILDEATSALDTATELAIQQSLAELSAGRTTLVIAHRLATIKNADRIIVVTEDGVAEEGAHQELVAAGGMYSRLHQAQFGT
>NC_015690.1|WP_013919872.1|6825635_6826718_-|GGDEF-domain-containing-protein
MPQDVFLNLSMNFLTMFVFFQLYFRYKVYVRSETVRHIILGVGFGLAQFLYRSFPIFIEGYREPIIIGGATFITAAVFGGGIAAFIAGCFPDLIGLAVRLIDPEGRPFMPGFLVFIWVTVAVVVLAFRFLKWRRWQIWLLLNFVFYVLLHFLTPNSASTSFAVYRMAIELGCGALIYYFVSYMHQAHVTQKQLERYALTDGLTGISNVRFFQEVFPKLFSAAQRGKIGLSLLVTDIDFFKKINDTLGHPAGDQVLVEYAGLLRDNFRGTEIITRNGGEEFSVMFANVNREQALEASKRFHELVRAHVFLEGHEKGPLKLTVSAGLAAYSGAYAEPGELYAAADEQLYKAKRDGRDRLYSV
>NC_015690.1|WP_013919873.1|6827006_6829793_+|family-43-glycosylhydrolase
MKKWASTLVLAVLLSSAGTPAAYADNPVIKDVFTGDPAAFVHGDKVYLYTGHDEAAPNGNFFVMKDWLIFSSSDLVNWTREGSLDLSTFAWAQPNSAWASQLTERDGTFYWYVTVLNQDGTGYSIGVATSDNPISGFKDALGKPLVSSPMTQAPESMGTAPWDDIDPSVFIDDDGQAYLYWGNTHCYYAKLKPNMTELDGEIHRVTINNMEGTYTEAPWIHKHNGTYYLSFAHNYPEELAYATSSSPAGPWEYQGLLLDALTKDGSDPAASNTSHQSIIEFKGKSYLVYHNSALPTGGQYRRSVAIDRLHYNEDGTIRKVIPTSTGLDGTAHKLESYTNPAKYVRHLDGDVRLDPVDSSVFDSKWHIVPGLADSGAGYVSLQSVDRPGYYLRYSGSDASLGKHDGTPAFAESATFKVNPGLADASLSSFEAYSQPGHYLRHAGSQLKVEAVSGEAAEADATFRTTEADVRGLTLDQQSLLLQKGTQSVLTASVQPASALNPKVIFTSSNPNVAAVGAPAVHPENGTVTVTVQAKSPGTATLTARTEEGQYTASADVTVEAAGTAGAITNVKIGVSAEAKKVTIEGQSTYGTGNEIAVRVRKPDGTVDFLDQTTSGDGGSFTLGIPLANPVKGEYQVSLGAADVSEPYTAKFEYTPAAAGGNPGGGHSGSDSGGGSDSGSGNSSDDDDDDDNGSGGGTGGGSAPAAESDTASPGQSGGSAHSGSHASGPKPGSAKPAAPVFRDVQEGYSWAQEAIEALAAQGIIQGTSESTFEPGRLVSRADFITLLVRAFGLKGTLQGGSFADVQPGDYYYEAVSLARSLGLTDGVDGSRFDPQAEISRQDMMVLIARALKLTNKAELGGSPDGLKAFADAADVADYAAESTAALIQAGVIQGDGGALHPRSSATRAETAVMLHRIWNTFLKEGGPSQ
>NC_015690.1|WP_013919874.1|6829789_6833629_+|family-43-glycosylhydrolase
MRLAKPIVSCITALTLLAAPFTSLPLQRVSAASVDDGLLLRYAFDDGTDSRTAADSSGGGHTGELVGDATITDTDKGGAVDLSGSGAYVRMPAGILDGLTDLTVSAWVYMDTAKPWASLYSFGNYKDSTNEAFSGLNFAPVNDASKSSLELFKTGFGSNQFLNLDPVPAKSWKHVTTVISGTRKTNSLYVDGVLQGTLTGMNALPGDIASTYNYIGYAQFPWEQGTGKGLDGRVADFRLYGRALGWQEIRTLAGAQAEVVSVETAEVSTTAGVAPALPSTVNLRFGDGSTEPAAVTWDSIPAGAYATEGKFIVNGTAEGSPLPAAANVTVLAELQIVSAEPVEVITAAGSAPSLPSVVTAVYNNGTKSEVPVTWAEIDPSLYAEPESRFTVKGSIAGTAAQAEAVVTVSGGIPEGLVTWYRFDALNGTTVPDASGHGRNATAVNGPLIMNVKEKTAIDFDNTKKQYVQLPAGIMSSLDDFTLATWIYIDSKTGDWTRIFDFGTGVSAGKMFLTTNLRYDMEGSIADATPSAPKVEQWTHVAVTKSGTVYTIYVNGKQAAVGTSTKKPSDYGETAYNFIAKSNWTADPYLDGKLRDFRIYSKALPQQEVAGIVTSSYSDREAVAAAKEVLTLGDTTQVVSDLELPVQGGNGVSITWTSDKPAVVSSTGKVTRPAKEEQDAAVTLTAELSRGEYKETRAFQVTVLADSIVSVDEVRVTTGRDFPPALPDNVTVRHYDGHTAEVPVTWERLPLEKLSAPGTFTLNGTVFSTALPAAAQISVAELVSIDEVKAETAAGQAPELPDTVNARYSDGTVKALPVTWSEVPVSAYDKPGTFAVQGSAATESYGNPLIERRADPHIMKHTDGYYYFTASVPEYDRIILRRAKSIQGLAEAEEVTVWQKHASGEMGAHIWAPEIHFIDGKWYIYFAAGTKEDIWKIRPYVLESADANPLTGTWTEKGMIGKPAGNTASFSDFSLDTTTFEHNGQRYLVWAQKENGPSNLYIAPMSDPWTISGDQVLISTPDYAWERQTYWVNEAPSVLKRGGQIFISFSASATDHSYALGLLTASDTADLLDPKSWTKSPEPVLVSSEEAGQYGPGHNSFTVAEDGTTDLLVYHARLYKKIEGDPLYDPNRHTRVKRLTWNADGTPNFGPLVSGRQPGPAAAVTAAVTVTRDAAYTAETVFSSERPGTGGKLEAAVTLSNRKQAAGQLVVVMVRYDSTGAMAESRYVTVDMTGKAQETAKLSLTFPAAAAGHKVKVFVWEGGSPDASNLKPAAPPAVFE
>NC_015690.1|WP_014371821.1|6833770_6833962_-|hypothetical-protein
MTVHDLRQRIQYMQYLGFDEAKKMWVYTYREKYKHRGVFGLVSGKEKVVVLPSLHGLNLKKAF
>NC_015690.1|WP_013919876.1|6834373_6835156_+|amino-acid-ABC-transporter-substrate-binding-protein
MKKRLAAIGLVLTAAFTILTGCSGDTGAAGGDKKLVVGIDDKFAPMGFRDEKNEIVGFDIDYAKAAAEKMGTEVEFQPIDWKTKESELNSGRIDLIWNGYTITEERKGKVLFTKPYLKNAQVVVTLAKSNLSKLDELEGKTVGLQSLSSAADALNASPVKSKIKTVTEYADNVLALSDLKIGRVDAVVIDEVVVKYYMAKEKDTFKLMSESLAPEEYGVGVKKGNEELLQKLQKALDELNQDGTAAKISQKWFGEDKVLK
>NC_015690.1|WP_013919877.1|6835232_6835892_+|amino-acid-ABC-transporter-permease
MSAGDYISMIKPMLEGAQMTVLLFLIAIAASIPLGFVLTLAVKSSIKPISWLAHSYIYVMRGTPLLLQLLFICFGLPMIPGIGEFLVLDRFAAACLGFILNYAAYFAEIFRGGLLAIDKGQYEASQVLGLSKWQTTTRIILPQMFRVALPSVSNESITLVKDTALLYAVAVPELLHYAQTVVNRDFTIVPFFFAGVIYLIMTLALTAFFKWLEQRFKFE
>NC_015690.1|WP_187296796.1|6835912_6836653_+|amino-acid-ABC-transporter-ATP-binding-protein
MIEVSGLKKSYGTLDVLKRITFDVSKNDVVAVIGPSGSGKSTMLRSLVHLEEVNGGTIRVAGEDLVRDGVYSKPQEIKRITAKMGMVFQHFNLFPHLTVQENLELAPRLVKGESSEALRRRSSELLEKVGLTGRAAAYPAKLSGGQKQRVAIARALMMNPEILLFDEPTSALDPELTGEVLQVMKSLAEEHMTMIVVTHEMGFAREVASRVLFMDNGEIIESGPPEQLFGSPQHERTKAFLGRSYQ
>NC_015690.1|WP_013919879.1|6836753_6837722_-|alpha/beta-hydrolase
MAKHVRLEPKAQKFAEDTAKPPYLFDLGPEKGRAKVDEVQSGEVTKLPVDIEERTIEGGPGGTVSVNILRPVNAPEQLPVIVYNHGAGWVFGNAHTHDRLIRELAVGAQAAVVFPNYSLSPEAKYPTAIEEVYAVVDWVAKNGRDLGLDPNRLAVAGDSVGGNMTAAVTLMAKERGGPAIRQQLLFYPVTDASFDTESYREFAEGYFLRRDAMQWFWDQYTESEAQRAEITASPLRATTEQLEGLPPALVITAEADVLRDEGEAYANKLREAGVRVTAARFQGTIHDFVMLNALADTAAARGAIALATAWLREGLGEKMGEQ
>NC_015690.1|WP_041617423.1|6837830_6838544_-|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein
MKRPMIGVLPLYDKEKESYWMLPGYMKGIEAAGGIPVMLPLTADPEVITAMADTFDGFLFTGGHDVHPELYGERIEPVCGEPCTERDEMERVLFREVTAMDKPAFGICRGLQLFNVLLGGTLYQDIPTQFGSDIQVNHQQQPPYDQPVHRVYIEKGDPLHEMLQTDSMEVNSYHHQGIKQLSSQLVAAAKAEDGMIEAVRMPDKKFVLAVQWHPEFSYTSDPYNFRLFEEFVSSCKS

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Crispr_ID: NC_015690_22

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015690_22

6921642-6921777

Orphan

Consensus_repeat	Method
AATAGCGGAACTGCGATGCCTTAT	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_015690_22

>merge|NC_015690|22|6921642-6921777|CRISPRCasFinder
AATAGCGGAACTGCGATGCCTTATTCGACTATTTCCCATCATTTCCCGAAGAATAGCGGAACTCCGATGCCTTATAAGGGGAAAATGGCCTGGAAACGGTGCTCATCCCTACAATAGCGCATCTGAGTTCCTTTAT

>NC_015690|22|16|6921642-6921777|CRISPRCasFinder
AATAGCGGAACTGCGATGCCTTAT	TCGACTATTTCCCATCATTTCCCGAAG
AATAGCGGAACTCCGATGCCTTAT	AAGGGGAAAATGGCCTGGAAACGGTGCTCATCCCTAC
AATAGCGCATCTGAGTTCCTTTAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_015690.1\|WP_014652445.1\|6917143_6918037_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223472
NC_015690.1\|WP_013919948.1\|6918063_6919035_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226666
NC_015690.1\|WP_013919959.1\|6933183_6935460_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|225117
NC_015690.1\|WP_013919957.1\|6930300_6931791_-\|sugar-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224053
NC_015690.1\|WP_013919953.1\|6924678_6926487_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|225519
NC_015690.1\|WP_049819073.1\|6903556_6904549_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226666
NC_015690.1\|WP_013919949.1\|6919470_6921066_-\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NC_015690.1\|WP_013919943.1\|6909551_6910619_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380629
NC_015690.1\|WP_013919951.1\|6922945_6923581_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_015690.1\|WP_013919956.1\|6929298_6930288_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224093
NC_015690.1\|WP_013919958.1\|6931982_6933098_-\|glycoside-hydrolase-family-88-protein	unknown	unknown	gnl\|CDD\|226678
NC_015690.1\|WP_013919940.1\|6904760_6908411_-\|discoidin-domain-containing-protein	unknown	unknown	gnl\|CDD\|227785
NC_015690.1\|WP_143768165.1\|6912565_6915418_-\|beta-galactosidase	unknown	unknown	gnl\|CDD\|366567
NC_015690.1\|WP_013919950.1\|6921960_6922773_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187632
NC_015690.1\|WP_041617441.1\|6923665_6924682_-\|substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|380661
NC_015690.1\|WP_013919942.1\|6908737_6909415_+\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|380440
NC_015690.1\|WP_013919954.1\|6926483_6928112_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|381091
NC_015690.1\|WP_013919955.1\|6928240_6929263_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380660
NC_015690.1\|WP_013919944.1\|6910839_6911325_+\|heme-degrading-domain-containing-protein	unknown	unknown	gnl\|CDD\|179430
NC_015690.1\|WP_041617440.1\|6915516_6917097_-\|DUF3502-domain-containing-protein	unknown	unknown	gnl\|CDD\|270298

Protein	Function_ID	Function_description	E-value
NC_015690.1\|WP_014652445.1\|6917143_6918037_-\|ABC-transporter-permease-subunit	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	2.7361e-57
NC_015690.1\|WP_013919948.1\|6918063_6919035_-\|sugar-ABC-transporter-permease	gnl\|CDD\|226666	COG4209, LplB, ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism].	9.28749e-98
NC_015690.1\|WP_013919959.1\|6933183_6935460_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	1.24027e-27
NC_015690.1\|WP_013919957.1\|6930300_6931791_-\|sugar-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224053	COG1129, MglA, ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism].	0
NC_015690.1\|WP_013919953.1\|6924678_6926487_-\|sensor-histidine-kinase	gnl\|CDD\|225519	COG2972, COG2972, Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms].	1.25927e-70
NC_015690.1\|WP_049819073.1\|6903556_6904549_-\|sugar-ABC-transporter-permease	gnl\|CDD\|226666	COG4209, LplB, ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism].	1.25209e-122
NC_015690.1\|WP_013919949.1\|6919470_6921066_-\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	6.00343e-59
NC_015690.1\|WP_013919943.1\|6909551_6910619_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|380629	cd19974, PBP1_LacI-like, ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors. This group includes the ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type 1 periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.	1.49994e-91
NC_015690.1\|WP_013919951.1\|6922945_6923581_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	7.2094e-08
NC_015690.1\|WP_013919956.1\|6929298_6930288_-\|ABC-transporter-permease	gnl\|CDD\|224093	COG1172, AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism].	3.58813e-81
NC_015690.1\|WP_013919958.1\|6931982_6933098_-\|glycoside-hydrolase-family-88-protein	gnl\|CDD\|226678	COG4225, COG4225, Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only].	4.05093e-85
NC_015690.1\|WP_013919940.1\|6904760_6908411_-\|discoidin-domain-containing-protein	gnl\|CDD\|227785	COG5498, ACF2, Predicted glycosyl hydrolase [Cell envelope biogenesis, outer membrane].	1.07842e-51
NC_015690.1\|WP_143768165.1\|6912565_6915418_-\|beta-galactosidase	gnl\|CDD\|366567	pfam01301, Glyco_hydro_35, Glycosyl hydrolases family 35.	2.24784e-67
NC_015690.1\|WP_013919950.1\|6921960_6922773_-\|SDR-family-oxidoreductase	gnl\|CDD\|187632	cd05374, 17beta-HSD-like_SDR_c, 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs. 17beta-hydroxysteroid dehydrogenases are a group of isozymes that catalyze activation and inactivation of estrogen and androgens. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	9.32142e-88
NC_015690.1\|WP_041617441.1\|6923665_6924682_-\|substrate-binding-domain-containing-protein	gnl\|CDD\|380661	cd20006, PBP1_ABC_sugar_binding-like, monosaccharide ABC transporter substrate-binding protein such as CUT2. Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems that share homology with a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein superfamily, which consists of two domains connected by a three-stranded hinge. The substrate specificity of this group is not known, but it is predicted to be involved in the transport of sugar-containing molecules and chemotaxis.	9.74172e-110
NC_015690.1\|WP_013919942.1\|6908737_6909415_+\|cupin-domain-containing-protein	gnl\|CDD\|380440	cd20306, cupin_OxDC-like, Oxalate decarboxylase (OxDC)-like cupin domain. This subfamily contains bacterial and eukaryotic cupin domains of proteins homologous to oxalate decarboxylase (OxDC; EC 4.1.1.2) such as MSMEG_2254, a putative OxDC from Mycobacterium smegmatis. OxDC is a manganese-dependent bicupin that catalyzes the conversion of oxalate to formate and carbon dioxide, utilizing dioxygen as a cofactor. It is evolutionarily related to oxalate oxidase (OxOx or germin; EC 1.2.3.4) which, in contrast, converts oxalate and dioxygen to carbon dioxide and hydrogen peroxide. OxDC is classified as a bicupin because it contains two cupin folds with each domain containing one manganese binding site, with four manganese binding residues (three histidines and one glutamate) conserved as well as a number of hydrophobic residues.	3.40685e-50
NC_015690.1\|WP_013919954.1\|6926483_6928112_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|381091	cd17536, REC_YesN-like, phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators. This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	2.83515e-51
NC_015690.1\|WP_013919955.1\|6928240_6929263_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|380660	cd20005, PBP1_ABC_sugar_binding-like, monosaccharide ABC transporter substrate-binding protein such as CUT2. Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems that share homology with a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein superfamily, which consists of two domains connected by a three-stranded hinge. The substrate specificity of this group is not known, but it is predicted to be involved in the transport of sugar-containing molecules and chemotaxis.	2.06299e-139
NC_015690.1\|WP_013919944.1\|6910839_6911325_+\|heme-degrading-domain-containing-protein	gnl\|CDD\|179430	PRK02487, PRK02487, heme-degrading domain-containing protein.	3.66253e-60
NC_015690.1\|WP_041617440.1\|6915516_6917097_-\|DUF3502-domain-containing-protein	gnl\|CDD\|270298	cd13580, PBP2_AlgQ_like_1, Periplasmic-binding component of alginate-specific ABC uptake system-like; contains the type 2 periplasmic binding fold. This subgroup includes uncharacterized periplasmic-binding proteins that are closely related to high molecular weight (HMW) alginate bining proteins (AlgQ1 and AlgQ2) found in gram-negative soil bacteria. The HMW alginate uptake system is composed of a novel pit formed on the cell surface and a pit-dependent ATP-binding cassette (ABC) transporter in the inner membrane. The transportation of HMW alginate from the pit to the ABC transporter is mediated by periplasmic HMW alginate-binding proteins (AlgQ1 and AlgQ2). Alginate is an anionic polysaccharide that is made up of alpha-L-mannuronate and its 5'-epimer, alpha-L-guluronate. Alginate is present in the cell walls of brown seaweeds, where it forms a viscous gum by binding water. Alginate is also produced by two bacteria genera Pseudomonas and Azotobacter. AlgQ1 and AlgQ2 belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. However, unlike other bacterial periplasmic-binding proteins that deliver small solutes to ABC transporters, AlgQ1/2 can bind a macromolecule and may have specificity for either sugar or a certain type of polysaccharide.	1.18425e-28

>NC_015690.1|WP_013919949.1|6919470_6921066_-|GGDEF-domain-containing-protein
MPGWIPKRLGLIKFQVLLTGLLAFSLAGTTAVLTGVALTKQNDSMTDSILQSNFEGARNLNVSMNKLLDLMMRELGAAAKFIGGQEGPLEQQAGYVNEMLGGRRFFAGAVLLDAKGVVRASTPGLPMQAGEALDEQVVEMALALPRPFVSGAFIAPNGHCAVLVSHPVMNRDGQRLGIVAGIIDLDERNVFSDFFEHASRSKNGTYAYLVNERGQVMLNPDDRRSGELIAPEVLRQTFPNEDIRYAAVRNTEGREVLAGYLTIPKIGWGIVFQSPAEVVDEALGVLIKAQLAWILPLFVLMLLVSLGIARKLAAPFAALTAAARQISAGERMVDPPFTRHWNYEAHHLAKAMMWAVGALQHQADRMSEQARTDGLTGLANRVCLEERVADMETGNQPYALLVLDIDHFKSVNDVYGHQTGDEALVHLARMISLEAGGESFAFRFGGEEFVVLLPGGGLEDGLDLAERIRSRMEHTVSPTGRPITVSIGAAACPRHGETFGEVFERADQALYQAKRSGRNRTAAAEELLPVG
>NC_015690.1|WP_013919948.1|6918063_6919035_-|sugar-ABC-transporter-permease
MNRAFAEPSVPSALTKQNQFTFWRKLRNNRTLLMMCLPAVLFFILFSYLPMPGLYLAFINYNYTDGIFGSEFIGLDNFRFLVESGDLWRLTFNTVAYNLAFILLGNALQIFVAIMLNELRSKFFKKVSQTLMFLPHFISAVLIGLIAYNILSFDYGLLNSILKSMGMEPVKTYSNPGIWPYIIILTYLWQSTGYGSIVYFAAIMGLDSEIVEAAEIDGANGFQRIRYIILPWLKPTFIILLLFSLGGVLRGNFGLFYNLVGANNTMLYSTTDIIETFVFRSLMNNFNFSMGSAVSLYQSLFGFAFVLTANWLVKKFSPDNSLF
>NC_015690.1|WP_014652445.1|6917143_6918037_-|ABC-transporter-permease-subunit
MNVRHTDRSSLIIRIVSYVFIALLAVSCLLPFVLIVATSLTSEASILKNGFNLWPKEFSTYAYRIVFENPELIIGSYIVTLGITLVGTAVGLFLVAMTGYALQRPDFHFRNKISFFIYFTTLFSGGIVPFYLLITQYLHLKDNYLAVLLPGLLSPFLIIMMKSFTQSIPHAITESAKIDGAGDFTIFMRLILPMSTPALATIGLFIALGYWNEWYNSMLFLSPDMKYRPLQLFLYNVVTSADFIRNSAAASNVPLRDVPLESMKMATAVVATGPVILFYPFVQRYFIQGITVGAVKG
>NC_015690.1|WP_041617440.1|6915516_6917097_-|DUF3502-domain-containing-protein
MVTRKIGMTLLSAVMAVSLTACSGGGNSESGKAAPGPAGTADSGQADTSKFETITYVMLGDKPKNGQVEKVLEKINVIMKEKINAKLELKWVEWADWQTKYNLLLASGEPVDLITTATDWLDAWPNAQKGAFLPLDQLLPKYAPETWKEIKPEEWDQTKYKDKIYMIPENSYTQWVNHGFFYRGDWAKEFGITEPIKDFETMGKYFQGIKDKKPDVIPWDSNGTNGEHAKGFIQSKTDAIELAVPTGYLPVVWGKSYDERYTAHSPIFDDTFVDFAKMMKAWADRGYWREDVLNYKGNVRDELKAGQTGADQHHTQTFSGLRTEMDAKQPGSELQMFAWSDTRGNLISQPITHGATAVGAKSKHPERALMAYELIRQNKEVYYLMNYGIEGVQYVIKDGKRAQPEGYDATRDGFSSNFWGGRVDRFEIPSATTWDGIKDIYKKYDGIKKPYPYGRFVLDKSKIDPQLTAMSQVTSQMGPAIAYGKAGDPVKAVEDLRSKLKAAGYDKVMAEVQRQLDEYKKLVESK
>NC_015690.1|WP_143768165.1|6912565_6915418_-|beta-galactosidase
MNEMNTVNERNVTHEAGQKGSVNPNVRFERDAVYIGGTPVILLCSSLFYFRIPRGLWKDRLHKVREAGYNAIDVYFPWNHHEREPGVWDFGGERDVEAFLKLAAEEGLWVVARPGPYICSEWDGGALPAHLLTDRSMRLRDNDPNFLRATDRWFSRILPILSRFELGKDGTVIAVQLDNELDFYDCQDPSGYISALRDMALAYGVSVPLFACAGQGDLYRATGHAEGVMPTCNFYPNDREPAFEDKVVRYAQTLGGRGYPLCVTETNRSHFLLRRLLAGGAKLLGPYLQASGTDFGFTNAINNWGKPLAFLTSDYDFHGMITPGGAKREEFYEGRLLGGFLRSMGSSLAKAATVPSFFSVQTDLTVSAGMRYVLALDGGGYVIALPNVDGKDGSAALHGDGQVIPQYTSLRLAPDRCPLLLYEFPLQHWGLEGRLRYSTAEPAAVRSSEQKLILVLTAEKDAESEIALSVPDAAVVADGGAEVYRNEQELVLCYRPGAEGCTEIRLGDGSLLEIRLLERHRASRLLEILPGGELRFEEETAGEGEASESVAEAETLNWRKVTLPLGGAALPQRWLELGDQAVHLEEAGIYRGMAWYEAKRREPAKQPVVGVLLQDAGDILSVYTDGTYAGTVIPGGGHAYIPLDPPAVVSDLLIRAEIWGHTNFDDSILPGLRLNALKGLSRAVMVTRQVSPMSNWNFQTCSPKQAGEPLAAGELDPGFCSIQSWGGWMTTRLPESGIYWKTFTASADADRWVLHVPGAACVVRVYVNRQYAGEIVQSLPFVDLTPYIDRDGEIEIALYLERRDHQAAGRVMLYEGSDAVHWRVAGCQEEQLWQASEEAAGQAAACELPVPLLPGEWAWLQTELPAGLAAKCRKLRCEGRSMKITAFFNGHLVGRVWLEGAGVRPHMTGGGQDVIYLPEPWYREGSSRLSLLVEGAGDDAELRRVAFMPV
>NC_015690.1|WP_013919944.1|6910839_6911325_+|heme-degrading-domain-containing-protein
MLELERKVKEMEEQERVFQFEEFTHETALELGLLLVQEAKRSGVRVTVDITRSGQRLFLHAMEGTTVGNEDWIRRKNNLTGRFGRSSWHTAMRLRLQGEELERDYGLPVKDYAAAGGSFPLHVKGEGILGTITVSGLPDQEDHDLVIGALQKYFDGLRQPE
>NC_015690.1|WP_013919943.1|6909551_6910619_-|LacI-family-DNA-binding-transcriptional-regulator
MAKKVTMQQIADYMGVSKFVVSKALSGKGGVSEATKEKVIKAASQLGYFSKMNPYLPPKPAESTQDGGTKQSVLVLMPNVRFQTKESVYWGRILDGISARLEAAGLGMMIVMEQSADHFLQALNPSGILGLIGVGEISSSVLLEVHRLGVPFILVDHEDGLIPSDTVFVNNYDSMHRLTNYLIGIGHKHLLFVGDPRYSRSFYDRWTGFRSAVEEQGLAPDSPASLLIRLEGYEGFTTQIQEVVEALRRKALPTALVCANDTIALDTIEVLQRMGIKVPQEVSVTGFDNIERSYQTSPSLTTVNVPKELMGSRAVEKLLERVSKDQDATEKLLIAGEVMYRESSAGAAKTAEAEV
>NC_015690.1|WP_013919942.1|6908737_6909415_+|cupin-domain-containing-protein
MPMTPDPDFSSPSAQFFFDLSQDLYFRKDARNFINRLSVKDLNTLGGVSLLDIYLDTGNVVEPHIHQNASELVYVITGSAVISLINPFTNELLNYTAGPGQVVNIPQGWWHYEVASADGTHLLAIFDSKVPEAIFGSDILRLTPSGVWAHTYGLDQAQVAAAFAPITGTTIIGPPLPGQQTTKPMPYVPYGSPRQPVYAEQAAHYQRPAYPAPYLAQGYGWPYPY
>NC_015690.1|WP_013919940.1|6904760_6908411_-|discoidin-domain-containing-protein
MKKHRMTLRGAKRSVLSTLALLTALSPLSLSHPQSARAAEPYLLSQNRTVYASSVEGANTPDLAVDGSTSSRWSSQWGADPQWIYTDLGAQAAISRVVIRWEGAFAKSYKIQVSNDESTWTDVYSTATGDGGVDEVTLSGSGRYVRVLGTERALSNYGYSILEFEVYGTGGVNPPPVNLGPNVALNRPVKVSSYEQSDYLPPGSTLPENGVDGSRQTRWSSNPTDNEYYQVDLGSQRTIGRIILDWEAAAGRAFDLQVSADGNQWTTIYREMKGQGGVQNIPVFATGRYVRMQGISRATSFGYSLFEFQVYDYVNGDPKPVYPITPLPAKSVVTEGSGSYLRNDITMPQPKYPLYKSDSLQKPLPSNDWWQSLFINKLGNGIITLPLKSKFQSQGLGIMTPGSGWITSDGKAVETGTNFDLTLMASNINTSSMSNRVVSYGDYSVDTVLSDSQTEDKMKVTFVKGSPYIYAQFSDPNSAEIYAPAVTRLFNDANAAVLAADGATLTADHIGIEVTNTDGAPNPAQVKRYYALNAPAGTVFKRIGPKIKITLPSGQNYLSLAALPSADKLNYFYQHGYAFVTDTKVGYTFNESTSAVETTFNTTTTLRRSGFPNTTLMTLAPHQWKIASTPLTDMTYPSIRGTLKVSEGNSFKTNDKFYGIVPQFTEPNDGGYSRQQLIQQLGILDQSTDTTEELMKADAYWQGKTLHPLAMGVLIADQIGDAAYKSKFLARLKTALTDWYTYTEGEPSYFLYYNDDWGTMYYKNSEFGANVGITDHHFTYGYFVFASAVLATYDKDFETRYGGMVEQLIRDYANPSRTDAQYPFFRSFDPYAGHSWAGGYADQDNGNNQEAAGESLFGWVGQYMWSILKGNKTYRDAAIWGFTTELKAVEQYWFNYDNDNWIPEYKHKSVGQIYGSSQFFGTFFNGNPVYVYGIHWLPTSEYLTSYGFDPAKAASLYQGFVTDNGGPETDWQHIVWPIQALSDPQAVLAKWNPAVLQQNEAFNTYYFVHALASLGHRTKDVWATGWSSATVYKKGTTYTAQVWNPTDAPVTVTFRNASGVTGTATVAPKSLVSVNPMTSSGGTQQPANVALNKTAAASSSEAGYAASQATDGNASTRWASEWNDAEWIYVDLGASYNVSRIKLNWEAAYAKGYKLQISDDPNSWTGKDVFVTAAGDGGVDDVNVTGRGRYVRLLGTARALPFGYSLFDFEVYGTQS
>NC_015690.1|WP_049819073.1|6903556_6904549_-|sugar-ABC-transporter-permease
MKTARSTRIPGAAVHAPKRAERREPGVWQRFAQQWDYQSMILPSILFLIIFSYIPMWGVLLAFKEYDLFAGFAASPWVGTLHFRMFFESPEFWLIMRNTICISLLKLAVGFPAPIVLALMLNEVANMAFKRVVQTITYIPHFISWVVVSGLVFSMLAVDGGAVNGLLLQLSLIDRPVNWLSVPEYFWAILVSAGVWKEIGFGSIVYLAAIAGIDPALYEAASLDGASRFKQIFLITIPSIAPVIIIFLILGVGNILHAGFEDILLLTQNLNNGILMPYAEVIDTYVYQMGIINQRYSYATAAGLFKSVISVLLLLIANYTARKLGKASLW
>NC_015690.1|WP_013919950.1|6921960_6922773_-|SDR-family-oxidoreductase
MKTILITGASSGIGRAAALYFQEQGWNVIATMRSPEKETELGRLDRVLVSRLDVVREETIQEALSQGIARFGTIDVLLNNAGYAAFGAFEGASEEQIHRQFDVNVFGVFRMTQAILPHFRANQEGTIINVSSIGGRVAFPLLTLYHASKWALEGFSESLYYELAGLKIRVKVVEPGNVHTDFTGRSLDLIRSDSLEAYKDYTETVLQKQVESFQANGSSPELIARTIYRAASDGTDQFRYLAGEDAEFVMNMRRERTDAEFMSWIAGSFR
>NC_015690.1|WP_013919951.1|6922945_6923581_+|TetR/AcrR-family-transcriptional-regulator
MRKPGSVDQYIERIKPVVRKTRFSQLKIDEVAKVMDISKATLYKYFSSGEDIISTIVDHYTDYVLQADTLVQEDSVPYPERFQRLYGHSLRCVIYGSNLFMQDLQENYPPLYDKLAAAQQVRNKNLTAFYESGMEKKIFNPMNPILFMIQDEAVLRSIVEPLFCVQYDLTLKQALLDFYTLKKFQLLTPEHLQAVDDSIIENEIVQLLQSL
>NC_015690.1|WP_041617441.1|6923665_6924682_-|substrate-binding-domain-containing-protein
MNKGWGMVLAVLLLLAAGLGYYGWTSGAEAKSRPILLIPKTTDPRISFWQAMRQGAEAAAREYGVEVQMAGMAAETEIEGQIRLLEEAILRKPRAIILAAADSNRLLPVCTRIKEAGIPLITVDSGLSAEAAASLIATDNYAAGRQVGDAMGALLKPGAKVAVISFVKGSTPAVERERGVRDSLEEKGITVAQTLYTNAEEELAYRLTMELLQSAAARELDGFIGLNEPSTVGAARALKEGQPEGGRVPMVGFDSSMREIAFLEEGVLQAIVVQKPFNMGYLAVKTAVEASSGVAAAPWVDTGAVTVTRSTMFSKANQKLLFPFGSEAYGGLVGESRD
>NC_015690.1|WP_013919953.1|6924678_6926487_-|sensor-histidine-kinase
MRGVRLFQYQSIHTQIALAFSALILCTTIILSYTAYRLSSDAVTGTSLEYTKELVRQVHTNVENYIYSMESIASLALSSGELKRYASLPRQNSEEGEELGRRLGDYFRSVLASRKDMASILFVGGHGGMVGGRSGESLKPSSEVRQQEWYLNAHQLEGGTAITSSHVQQLYRGEYPWVVSISKALPSTAAKPSGEGADGGVLLVDLNYSVIDNLCKQIQLGRRGYVFILAPSGDLVYHPQQQILNTQLKTERIPDILESRDGTMTFGRGAEQKIYTVSTTRFGWKVVGVVYPEDLARNKRAMQGSAALWGSLCLAVALSISVILSFRLTRPIKALEGHMKLAEKGDFGQRVEIESTNEIGKLARTFNVMIGRIQDLMEQIVQEQEQKRISELKALQAQIKPHFLYNTLDSIIWMAETRKVDEVVTMTSALAKLLRSSINQGEEWVPLAVELEQIRHYLTIQQIRYRRKFTYSIEVPEELYPYPIVKLVLQPIVENAIYHGIKHKAEPGHIRISGRRGAGGIELAVSDDGVGMTPEKLQTILGGTPRTKEAPGGSGVGVHNVHQRIALAFGPGYGLGFESELEEGTTVTIRLPELEDKGGAAG
>NC_015690.1|WP_013919954.1|6926483_6928112_-|helix-turn-helix-domain-containing-protein
MYSLMLVDDEDEVREGIMEKTDWAACGFRLAGAYENGRDAAEALEALRPDVLITDICMPFMDGLELSRYAAEISRDTKIVIITGYEEFDYAKEAIKLRVNEYLLKPINAREFMAFLGRLKTELDEQRASRENLSVIRQQLNQSLPLLKERFLERLSASVMKKEELHRKLEYFGLTLPGPAFVSMVADIDPRQNPQAAGGAADAGSDLELLHFAVFNIFQEIFEKENGGAVFRTRDDRIGVLLCGLPESIGPLAQNLAAHAAHSVEKYLKLTLTIGIGRHCTALTQVPRSFREAGSALDYRLLLGSNRILCISDLEQGTSLHSMEYLEWEKKLLSALKMGKGSQVSSVLSAWLEEWRSAGLPVEKCYGMLYKFVVALMNWVAETGCGEAEVFGEDPFREMRALRTLDQLKQWLEGLCHRVICTLGERRSLATQSQMHLAEAYIKEHYVSESLSLQQVCDHIYMSASYFSACFKQHTGLTFVEYLTRLRIDKAKELLAATALKAYDIASRVGYPDPQYFSVIFKRHTGRTPKEFRLLAAAGETV
>NC_015690.1|WP_013919955.1|6928240_6929263_-|ABC-transporter-substrate-binding-protein
MAKKKSWFALAGVTVMAAALLGACGGNGGGSQQANAPASSEASKAGDSQAAGKVYIPVISKGFQHQFWQAVKQGAEKAAKEYQVEITFEGPESETQVDKQIEMLQAALGKKPQAVALAALDSKAVAPLLQKAKAQNIPVVGFDSGVESDVPVTTAATDNKAAAALAADKMAELIGQEGEIALIVHDQTSRTGVDRRDGFVNRIKEKYPKIRIVDVQYGGGDHLKSTDLAKAILQAHPGVKGFFGANEGSAIGVLNAAAELKKEKLVIIGFDSGKQQIEAIRSGRMAGAITQDPIGIGYWSVKAAAMAVKGESVPKTIDTGFHWYDKSNMDSDTIKPLLYN
>NC_015690.1|WP_013919956.1|6929298_6930288_-|ABC-transporter-permease
MKVVSLNRQPSIRTGAMQKVLAFASLILLVVVFSLASSNFFRFDNLVAIILSTAVIGVLALGSTFVIITSGIDLSVGTVMTFASVMTGVIITTWQLPMPLGIIGGILTGAVCGLLSGLAVAKLKIPPFIATLAMMMITKGLSLVISGTKPIYFNDAPLFMDIAMGSVIGAVVPGFDIPNAVLIFFGLAVIASIILSKTIIGRFTFALGSNEEATRLSGVNVDKWKIIIYTITGAFSGIAGILMASRLNSAQPALGAGYELEAIAAVVIGGTSLSGGQGSILGTVIGALIMSVLTNGLRILSVPQEWQTVIVGLVVILAVYADMLRRRKK
>NC_015690.1|WP_013919957.1|6930300_6931791_-|sugar-ABC-transporter-ATP-binding-protein
MGEPLISMEGIVKRFPGVLALDGCRFELHAGEVHALVGENGAGKSTLMKILTGVYAKDEGRIRYEGREVEIPNTKAAQEMGISIIHQELNMMPHLTVAQNIFIGREPRRGWLLDEKALHRRTQELFGRLHLQLDPGTPVSELTVAKQQMVEIAKALSFDSRVLIMDEPTAALTQSEIEELFRIIEQLRSQGVGIVYISHRMEELKRITDRITVMRDGCYIDTVRTESITIDQIIAMMVGRQIRHLSRPSAAENRNPVVLEVRDLSRGTQLRNISFHLRQGEILGFAGLMGAGRTEAARAIFGADPVDRGEIRIHGRPVSIKQPHDAVAQGLGYLSEDRKQFGLLTEMDVKTNIAVASYAGCARWGWMDDKRIAQTAERYVQSLKIKTPGTGQLVKFLSGGNQQKVVISKWLTRDCDILIFDEPTRGIDVGAKSEIYALLEQLAEEGKSIIMISSELPEILRLSHRILVMCEGRITGELSSGEATQERIMRLATMRT
>NC_015690.1|WP_013919958.1|6931982_6933098_-|glycoside-hydrolase-family-88-protein
MEYGLVDKMKAQYRAEPKWYSVRWHYIEGCILKAYLDSWAQTGSEEDYQFVKGFIDRLYDEEGNIPAVNPAYYNIDQIRMATVLFPLYERERDPKYKRVMDLLYGQLSHYPRTNSGAFWHKSNYPHQVWLDGLYMGQPFYVQYTKQFAEPKEYSDTLAQFRNVRKNIYNEKKRLYSHAYDESRQMFWSDPVTGQSPNVWGRAVGWYVMALVDVLELLEGEEADARFLQQDLQDTIDDMLRHQHSEGMWYQVVDRADHPDNYLESSGTLMMAYAILKGVRLGFLPGEYAGHGKKAFDGTVSRYVREEEGEVLLGGICRSAGLGTHPDTGAVRDGSVDYYLHGEKIVDNNGHGAAPLLMAYNEIKRLLNQAAS
>NC_015690.1|WP_013919959.1|6933183_6935460_-|helix-turn-helix-domain-containing-protein
MPRYLYRLLVFTLLLVAAPVVSIGMISYYIASKDTEQKVNEGNTHMLLQNQMRIEQVLKHVEMGAVQYVSSSLVTDHLYDDLTPDDFVTITDLAKGLYNLHSLSGVADTHLVNLEHDWMISNLGFTKVRDYLEPDLLSEYSGNPKNLFWLAGGTGKKRGGSTEEEAPARETVRMVVKLPMIAPSSEPKALLIIDMDEQKLESDMTPNEQWGNMYVVSREGLPFLTNPGSVDLTDSILLHLKTLTNSSGYFEADGMAVNYRVSPYNHWTYASVNSIESMTKESKKIAVITLNACLIIFVIIAAGAYYGSRRMYSPFRRLFLMMERYGGEAAVSRQQDEFAYIEDRFNSLFRTRKQLQTQLQGQRGQMREFFVLKLLMGQITESEFTYKSETYGFAGKGRSMGVLTLQIDALHETRFTENDKELLLFAINNMVGELIPSSGLLGNVLLDQSQISILISDSNDPDACKAFLHQTAAWIKTRVYELLQLKVSIGISRSFTRYTDANHAYTEALEALKRRISLGNDIILHYDDMKLGSGQRSSACVSLEHFEDDVIHALKVGDAVSTAGHYDRYVEAIMEKEIGFNDFQMVMLQLVNRVYRLVNEQEGSLHSLVRNQSILNRFVKLHTASEMTAWFKQEFLPPILEYMRERVDRQYINIAHEMVQLIHEQYGRDLTLDTCAERLKYHPVYLSRVFKKEIGVTFIDYLTDYRMKMAKSWLENTDLKITEIAGRLNYTNATGFIRTFRKLTGMTPGQYRDSHSSG

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Crispr_ID: NC_015690_23

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015690_23

7247602-7247676

Orphan

Consensus_repeat	Method
TAGAGGAACTCAGGTGCGCTATTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015690_23

>merge|NC_015690|23|7247602-7247676|CRISPRCasFinder
TAGAGGAACTCAGGTGCGCTATTTTGTTCGTGGAGAGGTACGCTTCCGAGATAGCGGAACTCAGGTGCGCTATTT

>NC_015690|23|17|7247602-7247676|CRISPRCasFinder
TAGAGGAACTCAGGTGCGCTATTT	TGTTCGTGGAGAGGTACGCTTCCGAGA
TAGCGGAACTCAGGTGCGCTATTT

Protein	Signature genes	Signature genes Name	Protein_function
NC_015690.1\|WP_013920239.1\|7246941_7247418_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NC_015690.1\|WP_013920244.1\|7250457_7251402_+\|glutaminase-A	unknown	unknown	gnl\|CDD\|274797
NC_015690.1\|WP_013920234.1\|7240982_7241237_+\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_014652572.1\|7253314_7254844_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224053
NC_015690.1\|WP_013920241.1\|7248445_7249060_+\|pyridoxamine-5'-phosphate-oxidase-family-protein	unknown	unknown	gnl\|CDD\|377290
NC_015690.1\|WP_013920242.1\|7249252_7250131_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NC_015690.1\|WP_013920235.1\|7241462_7242254_+\|phosphatidylserine-decarboxylase	unknown	unknown	gnl\|CDD\|179544
NC_015690.1\|WP_013920250.1\|7257397_7258621_-\|response-regulator	unknown	unknown	gnl\|CDD\|381091
NC_015690.1\|WP_013920237.1\|7243816_7245217_-\|HD-GYP-domain-containing-protein	unknown	unknown	gnl\|CDD\|225116
NC_015690.1\|WP_013920238.1\|7245368_7246739_-\|PLP-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|224089
NC_015690.1\|WP_049819075.1\|7260503_7261514_-\|sugar-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380624
NC_015690.1\|WP_041617506.1\|7258627_7260445_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|225519
NC_015690.1\|WP_014372020.1\|7239913_7240507_-\|ECF-transporter-S-component	unknown	unknown	gnl\|CDD\|227065
NC_015690.1\|WP_013920230.1\|7237560_7238355_-\|energy-coupling-factor-transporter-transmembrane-protein-EcfT	unknown	unknown	gnl\|CDD\|223692
NC_015690.1\|WP_013920236.1\|7242400_7243663_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341031
NC_015690.1\|WP_013920247.1\|7254944_7256069_-\|sugar-binding-protein	unknown	unknown	gnl\|CDD\|380649
NC_015690.1\|WP_013920249.1\|7256408_7257278_+\|DUF1963-domain-containing-protein	unknown	unknown	gnl\|CDD\|370378
NC_015690.1\|WP_013920229.1\|7236811_7237474_-\|thiaminase-II	unknown	unknown	gnl\|CDD\|381699
NC_015690.1\|WP_013920231.1\|7238345_7239914_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213192
NC_015690.1\|WP_013920245.1\|7252147_7253311_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226669

Protein	Function_ID	Function_description	E-value
NC_015690.1\|WP_013920239.1\|7246941_7247418_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	5.59517e-17
NC_015690.1\|WP_013920244.1\|7250457_7251402_+\|glutaminase-A	gnl\|CDD\|274797	TIGR03814, Glutaminase_1, glutaminase A. This family describes the enzyme glutaminase, from a larger family that includes serine-dependent beta-lactamases and penicillin-binding proteins. Many bacteria have two isozymes. This model is based on selected known glutaminases and their homologs within prokaryotes, with the exclusion of highly-derived (long branch) and architecturally varied homologs, so as to achieve conservative assignments. A sharp drop in scores occurs below 250, and cutoffs are set accordingly. The enzyme converts glutamine to glutamate, with the release of ammonia. Members tend to be described as glutaminase A (glsA), where B (glsB) is unknown and may not be homologous (as in Rhizobium etli). Some species have two isozymes that may both be designated A (GlsA1 and GlsA2). [Energy metabolism, Amino acids and amines].	1.62584e-165
NC_015690.1\|WP_014652572.1\|7253314_7254844_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224053	COG1129, MglA, ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism].	0
NC_015690.1\|WP_013920241.1\|7248445_7249060_+\|pyridoxamine-5'-phosphate-oxidase-family-protein	gnl\|CDD\|377290	pfam04299, FMN_bind_2, Putative FMN-binding domain. In Bacillus subtilis, family member PAI 2/ORF-2 was found to be essential for growth. The SUPERFAMILY database finds that this domain is related to FMN-binding domains, suggesting this protein is also FMN-binding.	9.38014e-25
NC_015690.1\|WP_013920242.1\|7249252_7250131_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	9.63969e-27
NC_015690.1\|WP_013920235.1\|7241462_7242254_+\|phosphatidylserine-decarboxylase	gnl\|CDD\|179544	PRK03140, PRK03140, phosphatidylserine decarboxylase; Provisional.	4.87501e-101
NC_015690.1\|WP_013920250.1\|7257397_7258621_-\|response-regulator	gnl\|CDD\|381091	cd17536, REC_YesN-like, phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators. This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	1.81094e-56
NC_015690.1\|WP_013920237.1\|7243816_7245217_-\|HD-GYP-domain-containing-protein	gnl\|CDD\|225116	COG2206, COG2206, c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms].	2.11358e-71
NC_015690.1\|WP_013920230.1\|7237560_7238355_-\|energy-coupling-factor-transporter-transmembrane-protein-EcfT	gnl\|CDD\|223692	COG0619, CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism].	2.36797e-23
NC_015690.1\|WP_049819075.1\|7260503_7261514_-\|sugar-ABC-transporter-substrate-binding-protein	gnl\|CDD\|380624	cd19969, PBP1_ABC_sugar_binding-like, monosaccharide ABC transporter substrate binding protein. Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems that share homology with a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein superfamily, which consists of two domains connected by a three-stranded hinge. The substrate specificity of this group is not known, but it is predicted to be involved in the transport of sugar-containing molecules and chemotaxis.	2.59685e-117
NC_015690.1\|WP_041617506.1\|7258627_7260445_-\|sensor-histidine-kinase	gnl\|CDD\|225519	COG2972, COG2972, Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms].	8.19979e-79
NC_015690.1\|WP_014372020.1\|7239913_7240507_-\|ECF-transporter-S-component	gnl\|CDD\|227065	COG4721, COG4721, ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism].	1.00811e-39
NC_015690.1\|WP_013920238.1\|7245368_7246739_-\|PLP-dependent-aminotransferase-family-protein	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	8.31821e-105
NC_015690.1\|WP_013920236.1\|7242400_7243663_+\|MFS-transporter	gnl\|CDD\|341031	cd17478, MFS_FsR, Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters. Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	7.49874e-106
NC_015690.1\|WP_013920247.1\|7254944_7256069_-\|sugar-binding-protein	gnl\|CDD\|380649	cd19994, PBP1_ChvE, periplasmic sugar binding protein ChvE that interacts with a bacterial two-component signaling system. Periplasmic aldose-monosaccharides binding protein ChvE that belongs to a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein (PBP1) superfamily, which consists of two alpha/beta globular domains connected by a three-stranded hinge. This Venus flytrap-like domain undergoes a transition from an open to a closed conformational state upon ligand binding. Moreover, the periplasmic xylose-binding protein is homologous to the ligand-binding domain of eukaryotic receptors such as glutamate receptor (GluR) and DNA-binding transcriptional repressors such as LacI and GalR.	2.815e-167
NC_015690.1\|WP_013920249.1\|7256408_7257278_+\|DUF1963-domain-containing-protein	gnl\|CDD\|370378	pfam09234, DUF1963, Domain of unknown function (DUF1963). This domain is found in a set of hypothetical bacterial proteins. Its exact function has not, as yet, been described.	1.2754e-50
NC_015690.1\|WP_013920229.1\|7236811_7237474_-\|thiaminase-II	gnl\|CDD\|381699	cd19364, TenA_C_BsTenA-like, TenA_C proteins similar to Bacillus subtilis TenA. This family of TenA proteins belongs to the TenA_C class as it has a conserved active site Cys residue; the double Glu residues identified in the active site of TenA_E from the archaeon Pyrococcus furiosus is conserved in this family. TenA_C proteins (EC 3.5.99.2) catalyze the hydrolysis of the thiamin breakdown product 4-amino-5-amino-methyl-2-methylpyrimidine (amino-HMP) to 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP) in a thiamin salvage pathway. This family includes Bacillus subtilis TenA which has been shown to be a thiaminase II, catalyzing the hydrolysis of thiamine into HMP and 5-(2-hydroxyethyl)-4-methylthiazole (THZ), within thiamine metabolism. It has also been suggested that TenA proteins act as transcriptional regulators based on changes in gene-expression patterns when TenA is overexpressed in Bacillus subtilis, however this effect may be indirect.	7.52694e-111
NC_015690.1\|WP_013920231.1\|7238345_7239914_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213192	cd03225, ABC_cobalt_CbiO_domain1, First domain of the ATP-binding cassette component of cobalt transport system. Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC transport system of the CbiMNQO family is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most of cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems.	5.29805e-75
NC_015690.1\|WP_013920245.1\|7252147_7253311_-\|sugar-ABC-transporter-permease	gnl\|CDD\|226669	COG4214, XylH, ABC-type xylose transport system, permease component [Carbohydrate transport and metabolism].	2.88817e-155

>NC_015690.1|WP_013920239.1|7246941_7247418_+|GNAT-family-N-acetyltransferase
MTLPSSSIRIITAGRAELSAVVPLFDAYRRFYGQPSDPEGAERFLEGLMAHGDSVILLARQEGSAEALGFTQLYPGYSSVSMKRLWTLNDLYVRPEARGRGVAALLLEAAEGLARESGAKGLQLETAPDNRTAQRLYERMGYVRDEEYLHYFRSTMEN
>NC_015690.1|WP_013920238.1|7245368_7246739_-|PLP-dependent-aminotransferase-family-protein
MHFHIPYHSNLERYPTKLLALYHALRDSIVEGVLERGTRLPSTRELASAYGLSRGTVNQVYEMLAAEGYVDCRTGSGTYVAFRRSTRTSGAGAAAARPEEAPAYPLSPWSRRLGPPPGEPVHGGGEARLMDEPAQGWEPLREAIAQYLRRARGLAAEPGQIAITGGSVQAIALLAQLLIGPGEAAVVETPSYGGFRRAVRAAGGRCIDAPIDGEGIIPAAWDARVLFVTPTRQFPTGAVLSLERRQRLLEWADAKGAVIIEDDYDSEFRHRGKSLEPLRVLGGEERVVYVGSFTKSLLPPTRLGYAVLPPPLVEPFTRAQALFEPFPVNLLEQKALAAFMAGGAYERHLRRMKRSYGRKFHLLSELVKRELGSLVDWTESDAGLHLFGWWRGGEAEYRAFRSAGEAEGVRWSETEAELGGQRRFGLYLNFPHLTEEQIREGVRRMVRGGERSGQRS
>NC_015690.1|WP_013920237.1|7243816_7245217_-|HD-GYP-domain-containing-protein
MGNIASIALSPYRRFTWTLGLSVGFIGVLLSAVTLWACSTFVTRDTVELTTAAVVKHFAKVPQLAAIFPESSGEEGSTSPVGEPHTPHSQTPADLLQSYDRVLPLVRMHFDLYSILDANFYDTEGRIVFSYDKEAIGQEVDASLAGSLERAATNAQVVHQRLSGHILHLWMPVQREDGQVAGVVEVKRDISEQDRQIGWLEGILMTIIVLGMLGLFLTLHHVFRNSAGTIDRQNRELEAMVFRIERTYDESLQALSSALDSRDNETHGHSFRVTSYALRLGMEMNLTDRELGDLARGALLHDVGKIGVPDAILLKPAELTEEEWVVMKSHVEIGYRMLKHIAFLSPSLDVVRYHHERWDGGGYPHGLREEEIPLFARIFALCDSYDAMTSDRPYRKGWGYNEARAEIERCTGTQFCPEVVRAFLRIPKERWLEIEEASREGEPRELLGQMLEETMSMKAASMKGGR
>NC_015690.1|WP_013920236.1|7242400_7243663_+|MFS-transporter
MQLQTGAAAGPAAKPAPQPDVRPTLFRILFAISLVHLFNDTIQSVIPAILPIIKDSMQLSYMQAGIIVFALNMTASVMQPVVGLYSDRKPMPYMLPLGMGLTFFGVLGLALAPNYALVLVSVLLIGLGSAVFHPEGSRVAYMAGGSRRGLAQSIFQVGGNTGQSLASIMTALVFVPLGQFGAIWFTAVAGLAIVVQMYISRWYAGYLKAHPRPAKSAAARRIDPLRSRQIKFAVGMLIFLVFARSWYHAGITIYYPFYLMDKFTITLERAQLFIFLFTAAGVLSTFLGGPISDKIGRRNVIFFSMLGSAPLALVLPYANEFWTYVILLVNGFIILSSFSVTVVYAQELIPGKVGTVSGLITGLAFGLGALGAVALGGLIDVIKLRPVMELVSYLPLIGLLTFFLPRDRTLKEWSSESGNA
>NC_015690.1|WP_013920235.1|7241462_7242254_+|phosphatidylserine-decarboxylase
MKISFFRLLTELSSRKSVSQLTGAFAKSRASRSLIPRFAKTYGIPLEDAEKAVHEYVSLNDFFTRRLKSGLRPIDASPETMVSPVDALITGMGPIKEGSILNVKGQDYTIEELLNHSPRMINYKNGFYYVLYLSPTDYHRIHSPVDGTIIEKEHVPGKVYPVNDFGLKHMRRVLSRNERLITYVEHEGGEVAVVKVGALNVASIQYVAPLPDLLERGGELAYFEFGSTVVLLTETGTFESRSDLQVGSKVRMGEKLGSFKRRG
>NC_015690.1|WP_013920234.1|7240982_7241237_+|hypothetical-protein
MNETVTVPIESTPILLGLTAEMVSNCTYCTMISSDPGYRTPVSCTKLSGSCCPILVNLATCLTCGEYKNACGNGGASAEGTDAF
>NC_015690.1|WP_014372020.1|7239913_7240507_-|ECF-transporter-S-component
MSKGLKLTDILVTVVIAVVFAVIYRLWGDVYNVLKIPGLQLEQLGYGMWFIAGTVAFLILRKPGVAFLAEAAAASGEMIMGSQYGVEAFTYGLVQGLLAELVFAAAGYKRHTALIAGLAGAASGVGSIVYDYFKLYLAELQSWNLMLYIVFRLVGAFVITGPLAYVIVKALEKTGVTQLVRPASSLDYQALDRKKTL
>NC_015690.1|WP_013920231.1|7238345_7239914_-|ATP-binding-cassette-domain-containing-protein
MNAADTHTAHGSGGPSAQEQEPAVSVTGLRLKFPGSAPLLFDDLTLEVPRGQKVLLLGPSGCGKSTLLQVFSGLIPKSIEVPMKADALQLPDAWGYLFQDPDTQFCMPFVDEELAFVLENLQVPREEMGERIRLCLEQVGLRLPDLHTPIASLSGGMKQRLAIASLLALNPDVWFLDEPTSLLDPEGTGEVWETVKRVTEGRTVLIVEHKIEEIAGFVDRVVLFGHDARILADGPPQRVFREHRQELQEYGIWYPGVWEDYDRRPDLMPERGQSAARSAQVAQPLLRLEAFCGFHGREKKIEIPSADIFGDDWIAVVGPNGAGKSTLLQALMQLIPTQGRYNLGPRAVKGFDDVIGDASYVFQNPELQFVTHSVFDEVAWDFRQEGLPEAEVRTRSGEVLEWYGLAGHRELHPYQLSLGQKRRLSVASATGKARRLLLLDEPTFGQDAANTFALLEKLEEWRRGGSAIVMVTHDPEIVARFATRVWEVRGGRLAADLPPEAYRKLQAAGEAAAGKEAEAPCR
>NC_015690.1|WP_013920230.1|7237560_7238355_-|energy-coupling-factor-transporter-transmembrane-protein-EcfT
MPLTWTFRETWLHRANPAFKIGLSVLLFLAVLLTHNINVLLHVTWMHLLLFYTATGLPLRRLLLLSLPFVLMLVSSSTSMLFFGKGETTWLHWGLIHITEESFYRSLHIGLKTVNMAVLGLLFGLTTSPVRLFYSLMQQTRLPARYAYSFMAALRLLPMIVTEYQALQMALKVRGVKRARGIRGWTDSIQRHAIPLLAQSIRRAQRIAVAMEAKRFSSDAGRTYYYVIGWSASDLVLAAAALLIWTAGLLLGGHLPFLSVTDVR
>NC_015690.1|WP_013920229.1|7236811_7237474_-|thiaminase-II
MKFSQELREAADASWQASFNHPFVRGIGDGSLPLDAFRHYVLNDAYYLSQFARVQALGAAKANDLFTVNRMAVHAQGTYGAELSLHEKFAGLLGITEEERAAFEPAPTSYAYTSHMLRAAYAGGLGDIIAAILPCYWLYYEIGERLAGCTPEEPIYREWIAAYGGDWFRELVEEQIARLDELAETASSQDRERMKRHFVTSSRYEYMFWDMAYRKETWPV
>NC_015690.1|WP_013920241.1|7248445_7249060_+|pyridoxamine-5'-phosphate-oxidase-family-protein
MRRKEFSVEEQNEIDAFLNEMSYGYLATEGADGWPHLTPLNYAYWNGNIYFHGSRAGSKMKEIAQSDKVSFAVSKEYAIIPSYYSDPRQACPATAFFKSVHIRGIAEPVEDLDEKAGALSSMMEKLQPEGGYAPITAEDPEYRGELRGVSVVRITVSELTAKFKFGQNMSEERRAHIAESLAERGRPDDAETAELMRRFCPHHQ
>NC_015690.1|WP_013920242.1|7249252_7250131_-|AraC-family-transcriptional-regulator
MDQASLYHPRYLEEECHLRTVAYYSKQWNGFQMPFHTHRAAEIMYVISGECTVEFAEDRVHLGKGDFILIDALVAHRLFVEESTVCRMLNVEFVLGPRQGAFPSFRQLAEENEVLRAMLGRVRPYLVLSDTTDVYHTLKSLVLELSDRSRGGFMVQLLLSQLLLRVARLAAEAEEHQANPGDLYVKKVIAYLHHHYDCDLRVKELAEAVNLHPSYLHRIFRLHTGSSIVEYLTALRIEKAKMLLAQTDIPVIEIPGYIGMNSRQYFSAVFKKQTGLTPLQYRLGIEAWQRDE
>NC_015690.1|WP_013920244.1|7250457_7251402_+|glutaminase-A
MNPKNDLDLIAEKLPEWLEESRKYTVLGRPASYIPELAYAPAEALGVTVMGADGTEITAGDCGLTFTMQSISKVFTLLLALMDHGEDGVFQKVGMEPTGDDFNSMLKLELVPPGIPFNPLINAGAIAISSLIHGVSPSDKLSRILAFFREVSGDPDLTYNEAVYASESAHAHRNRSLAYFLKDNHVLDGDVEEVLDLYFKHCSIEVTCRHLARMALLLALNGKDPVSGRELIPKRYVAIAKTFMITCGMYNASGEFAIKVGMPAKSGVAGGILALVPGRFGVGVIGPALNHKGNSTAGVHLLQTMSEAMDWSIF
>NC_015690.1|WP_013920245.1|7252147_7253311_-|sugar-ABC-transporter-permease
MNTVKELFRGNIRQYGMVIALLFIMVFFQILTDGILLKPLNITNLILQNSYILVLAIGMLLVIITGHIDLSVGSVAAFVGAISAILMVDMQMHFVPAMLISLLIGALVGAWQGFWVAYVRIPSFIVTLAGMLLFRGLTMIVLDGKSIAPFPKTFQKISSGFLPDAFGGKIHMLTIIIGIVLSLILVFSEWRKRSTQQKYGFEVGSGALFALKLAAMVAVLNIFTYVLATYEGIPNILILLFVLIVIYTFVMNRTIVGRHIYALGGNEKAAKLSGVKTQRITFWVFVNMGVLSALSGLIFAARLNSATPKAGVNFELDAIAACFIGGASASGGIGTVIGAIVGGLVMGVMNNGMSLVGLGIDWQQGIKGLVLLLAVGFDIYNKNKGVS
>NC_015690.1|WP_014652572.1|7253314_7254844_-|ATP-binding-cassette-domain-containing-protein
MTDIILEMKNITKEFPGVKALERVNLQVKEGEIHALMGENGAGKSTLMKVLSGVYPHGTYTGDILFKGQVCEFKDIKMSENLGIVIIHQELALIPYLSIAENIFLGNERAKGGVVDWNETFVRTKELLDKVGLHESPNTQIAQLGVGKQQLVEIAKALAKRVQLLILDEPTAALNEDDSENLLQLLLELKRQGISSILISHKLNEISKVADSITILRDGRTIETLDMRRDNITEDRIIKGMVGRDLTQRYPEREPKIGETIFEIKNWNVFHPQQADRQVLHNINLGIRRGEIVGIAGLMGAGRTELAMSIFGRSYGQKISGTMIKDGRPLELRSIPEAIDSGIAYVTEDRKHYGLVLMDNIKQNITLANLGKISKRGVVDENREVVEAESYRKKMNIKSPSILQKTGNLSGGNQQKVVLSKWMFAEPDLLILDEPTRGIDVGAKYEIYTIIHQLAAEGKGVLIISSELPEVLGMCDRIYVMSEGRITGEFPRAEASQEKLMKFMTKTRG
>NC_015690.1|WP_013920247.1|7254944_7256069_-|sugar-binding-protein
MKKAVSMMMLLVLLFSLAACGGGGGAAETTGGAAQTEGGSGGDGKAGKVGISMPTKSSERWVSDGANMVKEFEKLGYQTDLQYAEDVVENQVSQIENMITKGVKVLVVAAVDGESLTDALDKANAAGIKVIAYDRLIKKSEHVAYYATFDNFKVGVQQASYIEKKLGLKEGKGPFNIELFAGSPDDNNAYFFFDGAMSILKPYIDSGKLVVRSKQTEMKQVATLRWDGAAAQARMDNLLSANYATEKVDAVLSPYDGISIGILSSLKGVGYGSGSKPLPVITGQDAELASVKSIIAGEQTQTVFKDTRELAKKAVAMADAVLKGKEAEVNDTKTYNNGVKVVPSFLLEPVSVDVTNYEQVLVGSGYYTKDQLAK
>NC_015690.1|WP_013920249.1|7256408_7257278_+|DUF1963-domain-containing-protein
MNKETILQALDAAGLGPYRDAISRLIYPSHRLLLHGTVENSMPPGASKIGGCPDLPPDLEWPTWRGYPQSFIAQLNLADLPPISPLPAAGVLYFFYAAQAMYGVRGFYEDPRTCSVFYLGADRIPSLQRRPHPETLDAGSTLYASRIEARPTLCVPSADSAYLESLGLGWDSNSEDYDTYWEMFLPQLEDRPSGIIHRLLGHPDQIQADMQMECEMLRRGWTWEDIGRPDQRQNLLPSAADWRLLLQIDSDERMTGMTWGDAGKIYFWIREEDLASLHFDGVTCIMQCT
>NC_015690.1|WP_013920250.1|7257397_7258621_-|response-regulator
MEKRWKVLIADDEPWIREGIRDAVDWTSLGMEVVAEAEDGEEALELALEHSAEVLLVDLNMPIMNGIELMKRVREELPGSRIVVITGHDEFVFAQEAIRLEVDDYILKPADPKQLHTVLGNVRRKLELAEKQNGYLAMASKQISKNFPLLRERFCLEWVEGTMTEGEILEQLQFLELPASAPQRLGIIRWPESSAPQRLMKESDRQLLLFAIENIAAELLEPYRHAMFRDTMGLLVVCLWEAVPESVYAEIERAVQTYLKLTVHLCFEHVEGSVTGIASVYRHCRTKVYEEQQISPIVRRARQYIRDRFTDSGLTLESAAAELQMSPVYLSRVLKQELGMPFVSLVTQMRIQLAVQLLGGTDLPVGEIAERAGYESQHYFSTAFKKVMGVSPNQYRRGVVSAGEQME
>NC_015690.1|WP_041617506.1|7258627_7260445_-|sensor-histidine-kinase
MNDLPIRDKLIIHFLLIIILPSVLLGGSILWTVDRIIEKQVSENTLQLIGKVNKTLESYAGNMQNITYFLSFQPEVKRFLERGPGTAQRGAAAEEYEIRQFMQGFTTLYPEVAGVLVVNAQGDYISNEMYARSSRSLTEEEWYKQAVASKGIFTMVGHPQGRNVTTHVSYKDSEVVSAVRAILDPQTQAVKGVVLIDLKLRVIAETAKDVRLGKSGYLTIIDGQGDVIYAPPRPLVSRIPAEWLGDHGSGTFAQEVGGEKLQFIYRASPFTNWTTVGVFSMEESALEAQEIGFYVVCFVFIVCLFGIAASYYLSHSISRPIVQLMSFMRIAESGDLTVRYWGDRRDEVGNLGRSFNTMIAQIDKLLTLTERQERQKREAELRSLQAHIKPHFLYNTLDTIHWMARKKGAEDVAEVVQSLSRLFRIGLSKGSDRIMLAHEIEHICSYLTIQKSRYKDKLNYTIDVPEHLMNVSVLKIVLQPIVENAIYHGIKERRGPGHISVEAEERWGMLLLRVRDDGAGMDAEKLRELQERLAAAAASEDEQGEPREPASYGMMNVQARIQLAFGTSYGLTIESEAGQGTTVTIIHPLLRDGLPPVKRTSEGGT
>NC_015690.1|WP_049819075.1|7260503_7261514_-|sugar-ABC-transporter-substrate-binding-protein
MKKLLWIYAILIATFILYVVQYHTREVSSRAGGAHDGLRGEIGEKYVMVTFQSGMEYWKSSLKGFEDAAQALNVSVEYRGATQYDVHEQITVLEQVIAKKPEGIALSAIDPVRLTAAINKAVDAGIPVVLFDSGAPESRALSFLSTDNYNAGVTAARKMAELLGGQGEAAVVTLPGQLNHDERKQGFIDTLHKEYPQIRLQSVKDGRGDRIYSKLAAADILKEFPEVDGIFATEANGGVGVGEAVQEAEAAGKVKIIGFDTDKDTLDMVKKGAISATLAQGTWNMGYWSLQFLFHQHHGLAGPGGGTKAAASSLPRNVDTGITVVTGDNVEQFYAK

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Crispr_ID: NC_015690_24

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015690_24

7360041-7360166

Orphan

Consensus_repeat	Method
CGTTCCGTTGTGCTTCGCACAAAGGTCACTTTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015690_24

>merge|NC_015690|24|7360041-7360166|CRISPRCasFinder
CGTTCCGTTGTGCTTCGCACAAAGGTCACTTTCAAAATCATATATCCTCGCTTGTATCAAATGCATATCCGGGCGCTCGGGTATATGGTTTCTCGTTCCGTTGTGCTTCGCACAAAGGTCACTTTC

>NC_015690|24|18|7360041-7360166|CRISPRCasFinder
CGTTCCGTTGTGCTTCGCACAAAGGTCACTTTC	AAAATCATATATCCTCGCTTGTATCAAATGCATATCCGGGCGCTCGGGTATATGGTTTCT
CGTTCCGTTGTGCTTCGCACAAAGGTCACTTTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015690.1\|WP_013920343.1\|7358567_7358750_-\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013920339.1\|7355640_7355829_+\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013920336.1\|7350989_7351697_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_015690.1\|WP_013920347.1\|7362807_7363011_-\|YbdD/YjiX-family-protein	unknown	unknown	gnl\|CDD\|377308
NC_015690.1\|WP_013920342.1\|7356866_7358426_+\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|236901
NC_015690.1\|WP_013920352.1\|7369284_7370028_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227769
NC_015690.1\|WP_013920335.1\|7349480_7350803_-\|globin-coupled-sensor-protein	unknown	unknown	gnl\|CDD\|381256
NC_015690.1\|WP_013920349.1\|7365206_7365941_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225818
NC_015690.1\|WP_049819081.1\|7363003_7365124_-\|carbon-starvation-protein-A	unknown	unknown	gnl\|CDD\|184976
NC_015690.1\|WP_013920351.1\|7367732_7369172_-\|sn-glycerol-1-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|341454
NC_015690.1\|WP_013920355.1\|7372359_7373685_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NC_015690.1\|WP_013920350.1\|7366084_7367728_-\|histidine-kinase	unknown	unknown	gnl\|CDD\|225814
NC_015690.1\|WP_013920340.1\|7355818_7356598_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NC_015690.1\|WP_013920337.1\|7351729_7353862_-\|histidine-kinase	unknown	unknown	gnl\|CDD\|380161
NC_015690.1\|WP_013920334.1\|7348524_7349058_+\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013920346.1\|7360431_7362327_-\|PrkA-family-serine-protein-kinase	unknown	unknown	gnl\|CDD\|225357
NC_015690.1\|WP_013920353.1\|7370264_7371029_+\|polysaccharide-deacetylase-family-protein	unknown	unknown	gnl\|CDD\|213023
NC_015690.1\|WP_013920354.1\|7371193_7372123_-\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223566
NC_015690.1\|WP_013920344.1\|7358961_7359969_+\|UDP-glucose-4-epimerase-GalE	unknown	unknown	gnl\|CDD\|177883
NC_015690.1\|WP_013920338.1\|7354043_7355414_-\|MATE-family-efflux-transporter	unknown	unknown	gnl\|CDD\|240542

Protein	Function_ID	Function_description	E-value
NC_015690.1\|WP_013920336.1\|7350989_7351697_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.61883e-87
NC_015690.1\|WP_013920347.1\|7362807_7363011_-\|YbdD/YjiX-family-protein	gnl\|CDD\|377308	pfam04328, Sel_put, Selenoprotein, putative. This entry includes a group of putative selenoproteins from Proteobacteria, Actinobacteria and Firmicutes. The invariant cysteine at the C-terminus is encoded by a TGA Sec codon in some Epsilonproteobacteria, suggesting a redox activity for the protein.	1.69598e-23
NC_015690.1\|WP_013920342.1\|7356866_7358426_+\|PAS-domain-S-box-protein	gnl\|CDD\|236901	PRK11360, PRK11360, two-component system sensor histidine kinase AtoS.	1.73687e-71
NC_015690.1\|WP_013920352.1\|7369284_7370028_+\|hypothetical-protein	gnl\|CDD\|227769	COG5482, COG5482, Uncharacterized conserved protein [Function unknown].	1.84618e-55
NC_015690.1\|WP_013920335.1\|7349480_7350803_-\|globin-coupled-sensor-protein	gnl\|CDD\|381256	cd01068, globin_sensor, Globin sensor domain of globin-coupled-sensors (GCSs), protoglobins (Pgbs), and sensor single-domain globins (SSDgbs); S family. This family includes sensor domains which binds porphyrins, and other non-heme cofactors. GCSs have an N-terminal sensor domain coupled to a functional domain. For heme-bound oxygen sensing/binding globin domains, O2 binds to/dissociates from the heme iron complex inducing a structural change in the sensor domain, which is then transduced to the functional domain, switching on (or off) the function of the latter. Functional domains include DGC/GGDEF, EAL, histidine kinase, MCP, PAS, and GAF domains. Characterized members include Bacillus subtilis heme-based aerotaxis transducer (HemAT-Bs) which has a sensor domain coupled to an MCP domain. HemAT-Bs mediates an aerophilic response, and may control the movement direction of bacteria and archaea. Its MCP domain interacts with the CheA histidine kinase, a component of the CheA/CheY signal transduction system that regulates the rotational direction of flagellar motors. Another GCS having the sensor domain coupled to an MCP domain is Caulobacter crescentus McpB. McpB is encoded by a gene which lies adjacent to the major chemotaxis operon. Like McpA (encoded on this operon), McpB has three potential methylation sites, a C-terminal CheBR docking motif, and a motif needed for proteolysis via a ClpX-dependent pathway during the swarmer-to-stalked cell transition. Also included is Geobacter sulfurreducens GCS, a GCS of unknown function, in which the sensor domain is coupled to a transmembrane signal-transduction domain. Pgbs are single-domain globins of unknown function. Methanosarcina acetivorans Pgbs is dimeric and has an N-terminal extension, which together with other Pgb-specific loops, buries the heme within the protein; small ligand molecules gain access to the heme via two orthogonal apolar tunnels. Pgbs and other single-domain globins can function as sensors, when coupled to an appropriate regulator domain.	1.62721e-47
NC_015690.1\|WP_013920349.1\|7365206_7365941_-\|response-regulator-transcription-factor	gnl\|CDD\|225818	COG3279, LytT, Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms].	1.36419e-60
NC_015690.1\|WP_049819081.1\|7363003_7365124_-\|carbon-starvation-protein-A	gnl\|CDD\|184976	PRK15015, PRK15015, carbon starvation protein CstA.	0
NC_015690.1\|WP_013920351.1\|7367732_7369172_-\|sn-glycerol-1-phosphate-dehydrogenase	gnl\|CDD\|341454	cd08175, G1PDH, Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner. Glycerol-1-phosphate dehydrogenase (G1PDH) plays a role in the synthesis of phosphoglycerolipids in Gram-positive bacterial species. It catalyzes the reversibly reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in a NADH-dependent manner. Its activity requires a Ni++ ion. In Bacillus subtilis, it has been described as AraM gene in L-arabinose (ara) operon. AraM protein forms homodimer.	1.68435e-140
NC_015690.1\|WP_013920355.1\|7372359_7373685_-\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	4.17471e-17
NC_015690.1\|WP_013920350.1\|7366084_7367728_-\|histidine-kinase	gnl\|CDD\|225814	COG3275, LytS, Putative regulator of cell autolysis [Signal transduction mechanisms].	1.72399e-137
NC_015690.1\|WP_013920340.1\|7355818_7356598_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	4.21424e-19
NC_015690.1\|WP_013920337.1\|7351729_7353862_-\|histidine-kinase	gnl\|CDD\|380161	NF033092, HK_WalK, cell wall metabolism sensor histidine kinase WalK. This model describes WalK as found in Staphylococcus aureus (sp\|Q2G2U4.1\|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.	3.32754e-48
NC_015690.1\|WP_013920346.1\|7360431_7362327_-\|PrkA-family-serine-protein-kinase	gnl\|CDD\|225357	COG2766, PrkA, Putative Ser protein kinase [Signal transduction mechanisms].	0
NC_015690.1\|WP_013920353.1\|7370264_7371029_+\|polysaccharide-deacetylase-family-protein	gnl\|CDD\|213023	cd10918, CE4_NodB_like_5s_6s, Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands. This family belongs to the large and functionally diverse carbohydrate esterase 4 (CE4) superfamily, whose members show strong sequence similarity with some variability due to their distinct carbohydrate substrates. It includes bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, hemin storage system HmsF protein in gram-negative species, intercellular adhesion proteins IcaB, and many uncharacterized prokaryotic polysaccharide deacetylases. It also includes a putative polysaccharide deacetylase YxkH encoded by the Bacillus subtilis yxkH gene, which is one of six polysaccharide deacetylase gene homologs present in the Bacillus subtilis genome. Sequence comparison shows all family members contain a conserved domain similar to the catalytic NodB homology domain of rhizobial NodB-like proteins, which consists of a deformed (beta/alpha)8 barrel fold with 6 or 7 strands. However, in this family, most proteins have 5 strands and some have 6 strands. Moreover, long insertions are found in many family members, whose function remains unknown.	9.09629e-68
NC_015690.1\|WP_013920354.1\|7371193_7372123_-\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|223566	COG0492, TrxB, Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones].	1.01114e-60
NC_015690.1\|WP_013920344.1\|7358961_7359969_+\|UDP-glucose-4-epimerase-GalE	gnl\|CDD\|177883	PLN02240, PLN02240, UDP-glucose 4-epimerase.	0
NC_015690.1\|WP_013920338.1\|7354043_7355414_-\|MATE-family-efflux-transporter	gnl\|CDD\|240542	cd13137, MATE_NorM_like, Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.	1.86895e-83

>NC_015690.1|WP_013920344.1|7358961_7359969_+|UDP-glucose-4-epimerase-GalE
MSILVTGGAGYIGSHTCVELLNAGQSIVVVDNLSNSKMESLERVRELTGRDFRFYEIDLLDKDKLGSVFAENEIEAVIHFAGLKAVGESVAQPLRYYENNITGTLNLCEQMQKHDVKKLVFSSSATVYGMSEQVPITETSPLSATNPYGRSKLIIEEILRDLHVSDPSWSIALLRYFNPIGAHASGRIGEDPNGIPNNLLPYISQVAVGKLQELRVFGSDYPTVDGTGVRDYIHVCDLAAGHLKAVDKVRSTTGVEAYNLGTGKGYSVLEVIRAFEEASGQKVPYAIVDRRPGDVAVCYADPAKAREELQWTAQRGIEEMCADAWRWQTGNPKGY
>NC_015690.1|WP_013920343.1|7358567_7358750_-|hypothetical-protein
MRRPPYGVFHGWGPKYGYPHYGYPKFGPWGGVPLVLPLSIPAPVPYYPYPPYPYGPYPYY
>NC_015690.1|WP_013920342.1|7356866_7358426_+|PAS-domain-S-box-protein
MQKIPVIRDKKSSDITIISSDDVVKIECIRDKEFIIHTVSDKYYWAASLEVFEEWLYEEGFRLIDQMNVVNMNHVTGYEPRKGVVTLRTGSSPRYKTASAAWIHGEHIMNVRSLLAKMKELDQGIPPSHEGDELFETVLAQEEDHRFARSYAMIKALYEKKKAELLLEESELRYKSLFEHNPDPICSLNLNGMLTSINPAMFQVIGYSEQELSGGTIEPLILPEHYPRWFQHFQETLNGSTPHYELTFIHKEGYPVEASVLNFPIFVGKQIAGVYMIGQDISDRKRAEEMLIRSEKLSVVGQLAAGVAHEIRNPLTSLKGFVQLLQGKINGYDNYFDIMLEELDRINFIVSEFLVIAKPQSVRFQKKDAGAILQNTLMLMGSQALIHNVDIHTHIDPDLPPILCDENQIKQVFINILNNSVDSMPAEGGQIHIDFVRADHDQVLMRFTDQGCGIPEDRLPRLGEPFYTTKEKGTGLGLMVTFRIIENHGGTLKFHSSLGQGTTVEIFIPAVVPGGTLAV
>NC_015690.1|WP_013920340.1|7355818_7356598_-|class-I-SAM-dependent-methyltransferase
MNKKAANIWNAGHYDEKIRYVSRLGQSLIGMLQPAAGERILDIGCGTGDLAWEIAKSGAHVTGVDSSEAMIVQAAAKYPALQFRCDDAQTFRLQAGEAPYDALFSNAALHWIRRPAEAAEAMALALRPGGRLVVEFGGCGNIAAIYRGIRTALAAAGIDAEERNPWYFPGIGEYASLLEAQGFNVRTAELYDRPTPLGDGERGLRNWLDAFAGMFFSGLSEPQKEAAYARCEEAVREELYRGGEYIADYRRLRITAVKR
>NC_015690.1|WP_013920339.1|7355640_7355829_+|hypothetical-protein
MSNPLQELTREMNEIERRYAGLGARMERLERRLSEMEERLDHLEDQAALLPERTANKAPVTV
>NC_015690.1|WP_013920338.1|7354043_7355414_-|MATE-family-efflux-transporter
MIRQLAAWTQNWKLILTLALPSIISFASGTVTGTINLMMVGGMGALVIAVVGVSNIIAYNAWALCSGFGHSVNYLVAQNYGAGQMDQAVRRTYIALYVGLAAAVLAVLTGWLAPGLILRAMGGSPELVAAGGSYLMYRLYAVACFTLSFILHGFFRGIGDTRTPMVMTIAANVAMIFFTYTLTYGRWGFPELGLSGAGLAVLIGEALGLLGSAYVYFVRLNGRYGTRRRVTVDRGEASLILAESGKLGMQELAMSLAMFVFTMFVTRLGTEALAANEIALNVMGLGFMPAFGFGATATILVGQEIGRGNPLGARRMAGDVAVLGSLFLLVLGTAELVFSTEVARLYTQDQAVYELAGRLIMASAYLQLFDGLLNYYAGGLRGLGDTTFLLRVSLILNWLLFVPLAYGLTFTAGLGSMGAWFSLYAFLAAFAVVLCIRFYRTDWYSITVKQSPGHGG
>NC_015690.1|WP_013920337.1|7351729_7353862_-|histidine-kinase
MFSRTLWPYGAVLIISMCLFALVLAGGLAVLRQDGPPAAARQGVLTLDNPEQLRRGVLLEGEWEMFWGELLTPDDLAAAAPPRQGRPVVLPGTWTGLPSPEGKLPGLGYATYRLRVLLPPGTDDSSLLAVRIPPVNSAYRLWVGGTPVASAGEVGTTREASVPQYTKATAMFHSRNAELDIVLQIANFSHAKGGLRQSIELGGVEAVHRSADLAAGFDALLIGSLLIMGLYHLGLFSARPQSWSMFYFGMFCLLFSLRITLLGEVLLVKVLPGLDGELQLTLEYLTAVLSLPLFTRFFSNSFPQESSERYTRLFTLLPGAYALLVIVLPPVLFTRTLILLQLLISFCAVYIITIAARAARRRRTGARFLLVSCLLFFATVISDMLYAHELAVSRDTLSAFGLLFFVFSQSVMLSVKLSRTYVQEEQLTAALTALNSGLHSKVLERTAELEAANGELVRKNEELSRLESSRRRLISNISHDLGTPLTTIRCYLEAIMDGMVDTDEERERYVRLIHGKVLGMDRLIEDLFQLSQLEAGRVVFKFRPVPVDRLAGLLFGRYELDTRNSGIAYDLTVKRTGDAAGRAEFAVVEADMERLHQVFGNLIFNAMSFMSRGGRIEVTVTEDGSEMRCSVRDNGRGIEPKDLPYVFERHYSGRASPGKTSGGLGLSISKEIVEAHGGRIWIEWSEPGQGTLIMFTIPVHESAAPVEAVK
>NC_015690.1|WP_013920336.1|7350989_7351697_-|response-regulator-transcription-factor
MLGQTILLVEDDREIGEMIRKYLEKNEFRVVWSPNGGEAVALAARERPDLAILDVMLPDASGFEVCRELRGMTSAPILFLSCRKEEEDKINGLNLGGDDYITKPFSPNELVARVKANLRRPRLVAEGEPNGMKVQVGPIAIDRLSRTVTVEGRTVVLSRKEFDLLSFLALSPEKTFTHEELFREIWGQECFNDSRTIIVHISNLRKKIEPDPANPRYVINVHGVGYKFVRGISET
>NC_015690.1|WP_013920335.1|7349480_7350803_-|globin-coupled-sensor-protein
MSKCPFSTVAGWFGWKRDAKPAHHELFLKQEQMNQVAVSYTIDDSELDEQLRMIRFTEQDLRVIKMIQPLMVSQIDWIVEQFYDAVLKVGKLEKIIHDHSSVERLRRTLKVHLTELFSGQIDRKFVEKRIGIALIHQRIGLEPKWYMGAFQNLQNAFLQVVQTHVQDREESVVISGIVTKLLNFEQQLVLEAYEKENLRQRELEHERYRSDLRSISEELSLLTDVSSRSVDGLISSSGGVKEALEMTVQQSKTSQSLAGTGQERLNSLETRIHAIHDRADHMQTAIGQLSELMGQIKEIVTIVQDIAEQTNLLSLNAAIEAARAGEHGRGFSIVADQVRKLSEDTKTTLTRIGDIVSQSDKYNTNVIRSIAEVQQVVETSRKEAAEARRVFTGIMDSMQSNIDRTVDMESEMDTLQQVVREIGGAVSKVAASADTLRSRA
>NC_015690.1|WP_013920334.1|7348524_7349058_+|hypothetical-protein
MQEYITMAEALSVRAAITRRLHHLMQERMQNSTTVIEKGEQAEYPSRTVDLITEEIEKTSADYRTLDVLIAKANITHTIRWNDRDLTVLEAIELAKQTRSEIQMLNMLGAVKKMDRQVSRGGSSDGGKPLFTVALYDPEAYSRAAQKKEREAVRLSSLIEQSNHTHKLPFDASAYMG
>NC_015690.1|WP_013920346.1|7360431_7362327_-|PrkA-family-serine-protein-kinase
MSLFKKIADHRTETERLAWVGSFAEYVEKLRENPRLAMTAHARVYEMIASQGITEENGRRRYNFFDKEIFGLDSAVEKLVEEYFHSAARRLEVRKRILLLMGPVSGGKSTLVTMLKRGLEQFSRTDAGAVYAIQGCPMHEEPLHLIPHELRPEVEKELGVKIEGNLCPSCQIRLRDEYHGRIEDVLVERVLISEDNRVGIGTFSPSDPKSQDIADLTGSIDFSTITQFGSESDPRAYRFDGELNKANRGIMEFQEMLKCDEKFLWNLLSLTQEGNFKAGRFALISADELIIAHTNESEYKSFIANKKNEALQSRMIVMPIPYNLKVSEEEKIYSKLIQQSDMKHVHIAPHSFRAAAIFSILTRLKESKKQGMDLVKKMRMYDGEEVEGYKEADLKEMQNEYLEEGMSGIDPRYVINRISSALIRHDLEFINALDVLRALKDGLDQHPSITKEERERYLNFISIARKEYDELAKKEVQKAFVYSFDESAKTLFNNYLDNIEAYCNWAKIKDPLTGEEMDPDERLMRSIEEQIGISENAKKAFREEILIRMSSYSRKNRRFDYSSHERLREAIEKKLFADLKDIVKITTSTKTPDGNQLKRINEVIKRLVEEHGYTTASANELLRYVGSLLNR
>NC_015690.1|WP_013920347.1|7362807_7363011_-|YbdD/YjiX-family-protein
MFERVRTVLQYRQQFLDLLVGVPNYETYVKHMQECHPELPVQTREEFFREAQDARYNAKGGKVSRCC
>NC_015690.1|WP_049819081.1|7363003_7365124_-|carbon-starvation-protein-A
MQALSYPLEGNAVARSFKSILLWGIVSVLGAFAFATIALNRGESVNAMWLIIAAVSCYAVAYRFYSRFLAHKVFGLDDNRKTPAELKNDGKDYVPTNKWVLFGHHFAAIAGAGPLVGPVLAAQMGYLPGTLWIVIGVILGGAVQDFVILFASTRRNGKSLGEMIKEELGPVAGAIAMVGILGIMVILLAVLALVVVKALIGSPWGMFTIAATIPIALLMGMYMRYIRPGRVVEASLIGLVLLLGSLIAGKYVAESEYLSAMFTFSGEAIALMMIAYGFIASALPVWLLLAPRDYLSTFLKIGTIVGLALGIFVVMPELAMPATTKFIDGTGPVFAGNLFPFLFITIACGAVSGFHSLISSGTTPKMLERESHARPIGYGAMLMESFVAIMALIAACVITPGAYFAINSPAAAIGTDAVQAAAKLTSWGFTITPDDLTGLAKDVGETTILSRTGGAPTFAIGMAHILSGVIGGKALMAFWYHFAILFEALFILTTIDAGTRVGRFMIQEILGSFSKRLGNTESTLGNVVATALCVAGWGYFLYQGVVDPLGGINSLWALFGIANQMLAGMALILGSTILLKMGRKKYAWVTLVPTAWLLVVTMTAGWQKLFHPEAKIGFLKHAAQYKEAMASGKLIAPAKNMAQMQQIITNDYVDAALCGLFMIIVLLVFLSALRTWYRVLAKGQLEVNEAPYVARGQDGREATTYV
>NC_015690.1|WP_013920349.1|7365206_7365941_-|response-regulator-transcription-factor
MGYKVVIADDEAPAREELAYLTGQIPDVLSVVTASGGMEAVRRVQEEQPDLLFLDMDMPDLSGRQVAQLLAELQPGLKIVFSTAYDQYAVDAFKLRAFHYLLKPYDEEEVAEVFRELRKAAVPVTPKPAAAGGGCVKLALEVEGGIKYVFPAEVQYISKEGKHVLVHTGGRAYPVGYTLQELEQKLAPYGFFRCHKSYLVRLAAITELKSWINGAYDVRIDDEAGTTVPVSRNYVKELRLKLEI
>NC_015690.1|WP_013920350.1|7366084_7367728_-|histidine-kinase
MFHLLVDMLERVGFLIALAFVFSRSRWMRGYMSYGGDGTYPWRFVLFFSLYAMLGTYSGVTVTDYSYRPAPWIGEISPASAIANSRSVGVVIAGLLGGPWIGLLVGGLAGLHRYSLGGFVAVACMIAPLLQGLLGGLCRRPLRKRLRRASSSAIRLAFLAGLLAELLQMGLILLIARPWHDALTLVSLIGGPQTLANSIGVALFFVLYQTIESEEDRIGTEHARKALHIADLTMPLWRLPFDRAVEEVARTLNEETKAVGASFLKGSSELAHQGRKTAYFIDLPLETQNRTTLGAFRLFYERVRELSPSRRLMLRTLAGLMSQQYAFVEAERQAQLLADAEIRSLQAQMNPHFLFNVLNTVKSFIRTKPDEARTLVTQLSRFLRTNMKNSSRTLITIREELELVTSYLSLTQARLGDQLQLVTEIDERAVERLLPPFTIQPLVENAILHGTRNSGRPGLIRIRIREQGGEVEVSVEDNGSGMPLHGERSGGEEHAGMALDNIAQRLGYHYGTEEPLEIRSEPGRGTLVRFRIPAPAEPSKPAARRLG
>NC_015690.1|WP_013920351.1|7367732_7369172_-|sn-glycerol-1-phosphate-dehydrogenase
MMDMELGWKLERAEGLGLEQAGEIDPWLGRSFYCESCGKDHAVPIRRVIIERGALAALPDYAQERELRSLLLVCDRHTAKAAGEELLGRCREAQLDARLVVLTEDEHGELAADERAIVQLLLHVDAASQAIVAVGSGTLHDIVRFAAFKTGRVFLSVPTASSVDGFASVGAPLILGGFKQTVPACAPEAVFADLALLAHAPQTLTAAGFGDMLGKYTSLADWELGRLLLDEHVCELSAEMTRQALARCVDHVDEIAAGTEEGQRRLMEGLILSGISMLIVGHSRPASGAEHHLSHFWEMRFLQLRRRALLHGAKVGVAAVRMAGLYAQTAQLSAEAVRAAAAQRLADPAFLSPAQAEAAIAAGYGTIADQVRAENAAELDPAGREALLRGIGERLASRWEAVQAVCRSVPGPEQMAQWLSRAGGPVAEAQLGVEPELVEQSLRYAKYVRSRYTILRLQEWLAGTAAQPEVAAGVQAQTE
>NC_015690.1|WP_013920352.1|7369284_7370028_+|hypothetical-protein
MAIKSETELYAPVKAYLEELGYSVRGEVRHCDVVAVRGEEPPLIIELKRSFSIPLLLQGIDRLRLTRSVYVAFERPAKGKAPHSATWPELRKLCGMLGLGMITVQFYKTRKPRVEVECHPLEGQALYPLASPPRHSKYAAGKLLQEFQERRADYNVGGSSKRKLVTAYREKSLQLASLLGSHGPMSPKQLRDLTGQAQAASMLQKNYYLWFRRVERGVYTLSPQGEEALKTYAHVVDGLPSLDMAQG
>NC_015690.1|WP_013920353.1|7370264_7371029_+|polysaccharide-deacetylase-family-protein
MSLTARRCARLFLLVCCLLLPVSASAVSAPQPVRIPVLNYHSITVDPGNRATITPVKFEEQMSHLAENGYTTLTLRQFTDIMEGRETAPEKPVLLTFDDGYADNYTEALPVLSRLGLNATLFVSPGVSATDPYFLTWDQIREMHEAGWDIQPHGMTHPHLPRLSAAKQEAELTEAKRLIEEQLGTTADVFCYPYGEYNRTTLRLLKKAGYRYAFTIKQGVTLPTQDPYRLTRIFVNGEESFETWRNRLEKAYQP
>NC_015690.1|WP_013920354.1|7371193_7372123_-|NAD(P)/FAD-dependent-oxidoreductase
MYDCIIVGGGIAGLQAAIQLGRYRHKVLVIDKQKGRSALCGSYHNLLGWPEGVSGPELRERGRRHAERLGVEFLEDEVIAAAKSDDQFQVALAGDGGSFKSQTLLIATGVMDRFPPLPGLEERLGESIYICPDCDGYEVMDRRAVVMGAGEAGSGMAMAISYWTDRIIYVNHDRSAVSTSKREALEARGIEYIEEEIEEVLGGEDKSFRGVRLKDGRVIEGERAFIAFGGNRVITDWAMPLGIERLENKHIVTDPRTKMTGVPGVWAAGDVGIHAEQTSIAMGEGALAAIWIHKELVKRLRQKNVEHSG
>NC_015690.1|WP_013920355.1|7372359_7373685_-|MFS-transporter
MGSLGQWAKEQWSLRREAVPEERRLSKEAGVSLFIHFCFQFGASMSGVFLTLYLWRLTHSLAINGIYYAVTYAVAPFAFALGGWLIKRKDRMVTYRIGIAMTAAFYLGVVFAGEKVAEYYLVFAVLNGISSAFYWAGYLTLMYDVSTDSNRIRFLAINMVLFTLGGLIGPALAGFMITQSEGLQGYTLVFGTACFMFLIATIVSMKIPLKPSHHKAYYLKFTGLLMHRSRAWLHSLLAFGLMGLFQGMMLFLPNILLFQLVGREDLVGYLGVLYAGLSIGTNLFLSRFGSEEKAVKFIVISTAGFLFATFFLIWKMTLFTVIAFMIIYSVCAPLQGNTITSTYFRIIGRLPLKGQLRVESVVMREVFLNGGRVVSIFSLLGLMEYAGDQVLPWVLAAASLLQIGLAGLISSREEGEGRQAHRLLARTGKDNAPGGTAGTRL

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Crispr_ID: NC_015690_25

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015690_25

8017861-8017936

Orphan

Consensus_repeat	Method
AATAGCGCATCGGAGTTCCGCTAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015690_25

>merge|NC_015690|25|8017861-8017936|CRISPRCasFinder
AATAGCGCATCGGAGTTCCGCTATTTCGGCCAACACACTCGCCAATTGAGCGAATAGCGAATCGGAGTTCCGCTAT

>NC_015690|25|19|8017861-8017936|CRISPRCasFinder
AATAGCGCATCGGAGTTCCGCTAT	TTCGGCCAACACACTCGCCAATTGAGCG
AATAGCGAATCGGAGTTCCGCTAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_015690.1\|WP_013920975.1\|8022082_8022778_-\|phosphoribosylformylglycinamidine-synthase-subunit-PurQ	unknown	unknown	gnl\|CDD\|235140
NC_015690.1\|WP_013920978.1\|8024112_8025408_-\|adenylosuccinate-lyase	unknown	unknown	gnl\|CDD\|176464
NC_015690.1\|WP_128759009.1\|8005634_8006633_-\|iron-siderophore-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238566
NC_015690.1\|WP_013920971.1\|8015419_8016049_-\|phosphoribosylglycinamide-formyltransferase	unknown	unknown	gnl\|CDD\|235544
NC_015690.1\|WP_013920981.1\|8027556_8028249_-\|hypothetical-protein	unknown	unknown	unknown
NC_015690.1\|WP_013920969.1\|8013440_8014169_-\|IMP-cyclohydrolase	unknown	unknown	gnl\|CDD\|377923
NC_015690.1\|WP_013920974.1\|8019858_8022105_-\|phosphoribosylformylglycinamidine-synthase-subunit-PurL	unknown	unknown	gnl\|CDD\|234921
NC_015690.1\|WP_013920976.1\|8022824_8023070_-\|phosphoribosylformylglycinamidine-synthase-subunit-PurS	unknown	unknown	gnl\|CDD\|376904
NC_015690.1\|WP_013920980.1\|8026650_8027136_-\|5-(carboxyamino)imidazole-ribonucleotide-mutase	unknown	unknown	gnl\|CDD\|376377
NC_015690.1\|WP_014372470.1\|8016045_8017089_-\|phosphoribosylformylglycinamidine-cyclo-ligase	unknown	unknown	gnl\|CDD\|235439
NC_015690.1\|WP_013920964.1\|8007946_8008993_+\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376439
NC_015690.1\|WP_013920968.1\|8012168_8013428_-\|phosphoribosylamine--glycine-ligase	unknown	unknown	gnl\|CDD\|234856
NC_015690.1\|WP_013920970.1\|8014235_8015423_-\|phosphoribosylaminoimidazolecarboxamide-formyltransferase	unknown	unknown	gnl\|CDD\|180841
NC_015690.1\|WP_013920977.1\|8023185_8024079_-\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	unknown	unknown	gnl\|CDD\|133469
NC_015690.1\|WP_013920966.1\|8010172_8011408_-\|glycosyl-transferase	unknown	unknown	gnl\|CDD\|273616
NC_015690.1\|WP_013920979.1\|8025457_8026654_-\|5-(carboxyamino)imidazole-ribonucleotide-synthase	unknown	unknown	gnl\|CDD\|235674
NC_015690.1\|WP_013920982.1\|8028657_8029500_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|270620
NC_015690.1\|WP_014652928.1\|8006942_8007950_+\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376439
NC_015690.1\|WP_013920965.1\|8009040_8009868_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224045
NC_015690.1\|WP_049819122.1\|8018293_8019802_-\|amidophosphoribosyltransferase	unknown	unknown	gnl\|CDD\|223112

Protein	Function_ID	Function_description	E-value
NC_015690.1\|WP_013920975.1\|8022082_8022778_-\|phosphoribosylformylglycinamidine-synthase-subunit-PurQ	gnl\|CDD\|235140	PRK03619, PRK03619, phosphoribosylformylglycinamidine synthase subunit PurQ.	7.44847e-155
NC_015690.1\|WP_013920978.1\|8024112_8025408_-\|adenylosuccinate-lyase	gnl\|CDD\|176464	cd01360, Adenylsuccinate_lyase_1, Adenylsuccinate lyase (ASL)_subgroup 1. This subgroup contains bacterial and archeal proteins similar to ASL, a member of the Lyase class I family. Members of this family for the most part catalyze similar beta-elimination reactions in which a C-N or C-O bond is cleaved with the release of fumarate as one of the products. These proteins are active as tetramers. The four active sites of the homotetrameric enzyme are each formed by residues from three different subunits. ASL catalyzes two steps in the de novo purine biosynthesis: the conversion of 5-aminoimidazole-(N-succinylocarboxamide) ribotide (SAICAR) into 5-aminoimidazole-4-carboxamide ribotide (AICAR) and, the conversion of adenylsuccinate (SAMP) into adenosine monophosphate (AMP).	0
NC_015690.1\|WP_128759009.1\|8005634_8006633_-\|iron-siderophore-ABC-transporter-substrate-binding-protein	gnl\|CDD\|238566	cd01146, FhuD, Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA-like protein is comprised of two globular subdomains connected by a long alpha helix and binds its specific ligands in the cleft between these domains.	1.39125e-96
NC_015690.1\|WP_013920971.1\|8015419_8016049_-\|phosphoribosylglycinamide-formyltransferase	gnl\|CDD\|235544	PRK05647, purN, phosphoribosylglycinamide formyltransferase; Reviewed.	1.01667e-103
NC_015690.1\|WP_013920969.1\|8013440_8014169_-\|IMP-cyclohydrolase	gnl\|CDD\|377923	pfam07826, IMP_cyclohyd, IMP cyclohydrolase-like protein. This enzyme may catalyze the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to inosine monophosphate (IMP), a reaction which is important in de novo purine biosynthesis in archaeal species. This single domain protein is arranged to form an overall fold that consists of a four-layered alpha-beta-beta-alpha core structure. The two antiparallel beta-sheets pack against each other and are covered by alpha-helices on one face of the molecule. The protein is structurally similar to members of the N-terminal nucleophile (NTN) hydrolase superfamily. A deep pocket was in fact found on the surface of IMP cyclohydrolase in a position equivalent to that of active sites of NTN-hydrolases, but an N-terminal nucleophile could not be found. Therefore, it is thought that this enzyme is structurally but not functionally similar to members of the NTN-hydrolase family.	1.4088e-75
NC_015690.1\|WP_013920974.1\|8019858_8022105_-\|phosphoribosylformylglycinamidine-synthase-subunit-PurL	gnl\|CDD\|234921	PRK01213, PRK01213, phosphoribosylformylglycinamidine synthase subunit PurL.	0
NC_015690.1\|WP_013920976.1\|8022824_8023070_-\|phosphoribosylformylglycinamidine-synthase-subunit-PurS	gnl\|CDD\|376904	pfam02700, PurS, Phosphoribosylformylglycinamidine (FGAM) synthase. This family forms a component of the de novo purine biosynthesis pathway.	1.50974e-38
NC_015690.1\|WP_013920980.1\|8026650_8027136_-\|5-(carboxyamino)imidazole-ribonucleotide-mutase	gnl\|CDD\|376377	pfam00731, AIRC, AIR carboxylase. Members of this family catalyze the decarboxylation of 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR). This family catalyze the sixth step of de novo purine biosynthesis. Some members of this family contain two copies of this domain.	2.93203e-90
NC_015690.1\|WP_014372470.1\|8016045_8017089_-\|phosphoribosylformylglycinamidine-cyclo-ligase	gnl\|CDD\|235439	PRK05385, PRK05385, phosphoribosylaminoimidazole synthetase; Provisional.	0
NC_015690.1\|WP_013920964.1\|8007946_8008993_+\|iron-ABC-transporter-permease	gnl\|CDD\|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	6.48878e-83
NC_015690.1\|WP_013920968.1\|8012168_8013428_-\|phosphoribosylamine--glycine-ligase	gnl\|CDD\|234856	PRK00885, PRK00885, phosphoribosylamine--glycine ligase; Provisional.	0
NC_015690.1\|WP_013920970.1\|8014235_8015423_-\|phosphoribosylaminoimidazolecarboxamide-formyltransferase	gnl\|CDD\|180841	PRK07106, PRK07106, phosphoribosylaminoimidazolecarboxamide formyltransferase.	0
NC_015690.1\|WP_013920977.1\|8023185_8024079_-\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	gnl\|CDD\|133469	cd01414, SAICAR_synt_Sc, non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase. Eukaryotic, bacterial, and archaeal group of SAICAR synthetases represented by the Saccharomyces cerevisiae (Sc) enzyme, mostly absent in metazoans. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.	6.62936e-139
NC_015690.1\|WP_013920966.1\|8010172_8011408_-\|glycosyl-transferase	gnl\|CDD\|273616	TIGR01426, Glycosyl_transferase, glycosyltransferase, MGT family. This model describes the MGT (macroside glycosyltransferase) subfamily of the UDP-glucuronosyltransferase family. Members include a number of glucosyl transferases for macrolide antibiotic inactivation, but also include transferases of glucose-related sugars for macrolide antibiotic production. [Cellular processes, Toxin production and resistance].	3.57147e-116
NC_015690.1\|WP_013920979.1\|8025457_8026654_-\|5-(carboxyamino)imidazole-ribonucleotide-synthase	gnl\|CDD\|235674	PRK06019, PRK06019, phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed.	0
NC_015690.1\|WP_013920982.1\|8028657_8029500_+\|hypothetical-protein	gnl\|CDD\|270620	cd14667, 3D_containing_proteins, Non-mltA associated 3D domain containing proteins, named for 3 conserved aspartate residues. This family contains the 3D domain, named for its 3 conserved aspartates, including similar uncharacterized proteins. These proteins contain the critical active site aspartate of mltA-like lytic transglycosylases where the 3D domain forms a larger domain with the N-terminal region. This domain is also found in conjunction with numerous other domains such as the Escherichia coli MltA, a membrane-bound lytic transglycosylase comprised of 2 domains separated by a large groove, where the peptidoglycan strand binds. Domain A is made up of an N-terminal and a C-terminal portion, corresponding to the 3D domain and Domain B is inserted within the linear sequence of domain A. MltA is distinct from other bacterial LTs, which are similar to each other. Escherichia coli peptidoglycan lytic transglycosylase (LT) initiates cell wall recycling in response to damage, during bacterial fission, and cleaves peptidoglycan (PG) to create functional spaces in its wall. PG chains (also known as murein), the major components of the bacterial cell wall, are comprised of alternating beta-1-4-linked N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), and lytic transglycosylases cleave this beta-1-4 bond.	1.40426e-27
NC_015690.1\|WP_014652928.1\|8006942_8007950_+\|iron-ABC-transporter-permease	gnl\|CDD\|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	1.81859e-81
NC_015690.1\|WP_013920965.1\|8009040_8009868_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	1.80024e-128
NC_015690.1\|WP_049819122.1\|8018293_8019802_-\|amidophosphoribosyltransferase	gnl\|CDD\|223112	COG0034, PurF, Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism].	0

>NC_015690.1|WP_014372470.1|8016045_8017089_-|phosphoribosylformylglycinamidine-cyclo-ligase
MSDAYKQAGVDIAAGNEAVERMKKHVKTTFRPEVLTELGGFGGLFGLNKDKYEEPVLVSGTDGVGTKLKLAFAMDKHDTIGIDAVAMCVNDIIVQGAEPLFFLDYLACDKVIPEKIEAIVKGISDGCVQAGCALIGGETAEMPGMYSEGEYDIAGFTVGIVDKKKIIDGSTIRPGDVVLGLPSSGIHSNGFSLVRRLLLEQKGYKLDQALEALEGKKLGDVLIEPTRIYVKTILSLLEKVQIKGMAHITGGGFLENIPRVLPKNVNAHIQYGSWPILPIFHLMQQDGSISNNDMFRTFNMGIGMVIVVSAEEAEATLAAARELGESIYRLGEITTGEGIVTFEGAEV
>NC_015690.1|WP_013920971.1|8015419_8016049_-|phosphoribosylglycinamide-formyltransferase
MIERLRIAVFASGSGSNFQALTDAVQSGKLDADIELLVCDKPEAPVVQRAEAAGVETFLFRPKDYPSREAYEAEILERLRDKKIGLVVLAGYMRILTHVLVDAYWGRMINVHPSLLPSFPGLHAVRQALNHGVKITGVTVHIVDGGLDSGPILAQRALVIGPEDTEETLVERIHEIEHELYPQVVQAIADGSIKLDDIATSKEKDGMKS
>NC_015690.1|WP_013920970.1|8014235_8015423_-|phosphoribosylaminoimidazolecarboxamide-formyltransferase
MSQTTNQKHEIELRYGMNPHQKQAKLISEGNLPITVVNGDPGFINLLDALNGFQLARELRRATGLPAAASFKHVSPAGAAVAAPLTPELAKAYFVEGLELSPLATAYARARGADRMSSFGDAVALSDVVDASTALLLKREVSDLVVAPGYTPEALEILKAKKNGGYLMLQIDPEYVPNPVETRTLFGLTLQQERNDAVIDASALERIVTENKDLPDNAKRDLLIALVTLKYTQSNSICYTLDGQTIGIGAGQQSRIHCTRLAGDKADRWYLRQHPTALNMKFRQGLSRAEQNNAIDLWLEEELTPVEQAAWEAAFEEVPARLTREEKREWLKGLQGVSYGSDAFLPFRDNLDRASRSGVKYVVQAGSSMRDEEVVKAANDYGMVMCYSGVRLFHH
>NC_015690.1|WP_013920969.1|8013440_8014169_-|IMP-cyclohydrolase
MTTRAAQAERYLNSLKENVYPGRGIVIGQTPDGSKLVQVYWIMGRSENSRNRVFIQEDNGFLRTEAKDPAKLTDPSLIIYYPVKHLGGAHIVTNGDQTDTIHEALQQGGTFESALASRTYEPDAPNFTPRISGLVDLADEQFAYKLSILKSSGNTEDQTLRYTFTYEKALPGYGHCIHTYAGDGNPLPSFQGEPQLVPLANDAQTIAETYWNALNEENRISLLVKTISLETAEAELLVINKE
>NC_015690.1|WP_013920968.1|8012168_8013428_-|phosphoribosylamine--glycine-ligase
MRVLVVGGGGREHAICWALKKSPKVQELYCAPGNGGIASVAECVPIGVHQFEEIGQFALDKNIDLVVIGPDDPLAAGIVDHLERKNLKVFGPRENAAIIEGSKVFTKQLLKKYSIPTAAYESFEQYDAAAAYLDQLKAPYVIKADGLAAGKGVIIAQSKEEAETALREIMVDKIFGESGNQVVIEEFLTGQEMSILAFVDGETVKPMTPAQDHKPVFDGDKGPNTGGMGTYTPLPHIPQSIIDEAIETIVKPTAKAMVSEGRPFRGVLFAGLMITPDGPKTIEFNARFGDPETQVVLPRLQTDLLEIFLATVEGRLEEIDIQWSDEAAVCVILASEGYPGSYPKGLPIEGLESVQDAIVFHAGTAIQDGAVVTNGGRVLGVTALGRDIAEARSKAYAAADGIRFAGKHNRTDIAKKALV
>NC_015690.1|WP_013920966.1|8010172_8011408_-|glycosyl-transferase
MAHVLMINLPAEGHVNPTVGLVKELTARGERVTYYCTEDFKERLEGAGAVVRTYKNYHQELMGAGRPGAEGFDARQMMNFMLHGAELMVKGILPEVRQESYDYVIYDSMCVAGWIIADILGLPKVCSSTTFMIGEEMQERMPALMKERFQPDRDSELYLKSQEPVKRMEQEYGLDLSSLQSVPGIVSHPGDLSVVFTSRMFQIAGERFDDTHRFVGPSIAKRADSGDFPFDELEGHTVIYISLGTVFNEMKGFYQACFDAFRDAEAKVVLSVGRKINLEELPEPPANFIVRPYVPQLEVLQHADVFFTHGGMNSTSEGLYYGVPLAVLPVSADQPMVAGRVAEFGAGIALDHSKVTPELLRETAEKLLGEASYKGKAEQIAASFREAGGASRAAEDILSWSRTLQPQVPQG
>NC_015690.1|WP_013920965.1|8009040_8009868_+|ABC-transporter-ATP-binding-protein
MTAIQSKDLCLCYGETCIFQELSIRIPKGKVTVFIGSNGCGKSTLLRSLARLLKPQKGSIVLDGNEISRMSTKEIARRMAMLPQGPAAPDGLTVLQLVKQGRYPYQNWLQQWSKEDETMVQRALELTNMAPLAERTVDSLSGGQRQRAWIAMTLAQGTPTILLDEPTTYLDLAHQIEVLDLLYELNEREQRTIVMVLHDINLACRYADNIVAIKDRKVWAEGRPEDIVNEKLIKDVFDLESKVIEDPLFGTPMIVPVGKGKRPAAGKLPVRPVAL
>NC_015690.1|WP_013920964.1|8007946_8008993_+|iron-ABC-transporter-permease
MNRKSRYMTLRGSAYSFLISRRAVLITVLLLIALLAAVVLCTGIGSVFIPPAEVIRAILGTGTDASETIVRSLRLPRIVIGVLIGAALAVSGAILQGVVRNPLASPDTIGVTGGATLGAVSFFFFLTERVSIAWLPVAAIAGAFLAMVLVYGLSWKNGVTPLRLVLIGIGFSAAMSSLSHMMMLTGPVVVANKALTFMTGSIYGVSWEKDVLILLPYVVVLLPLVLLYSRHINIQELGEEIALSVGSAVQRQRLLLLLFSVALAGAAGAFGGAITFIGLMAPHMARKLVGPSFGALLPVSALLGALILLGADLVGRTAFSPLDIPAGVFTAAIGAPFFVYLLYRSRNR
>NC_015690.1|WP_014652928.1|8006942_8007950_+|iron-ABC-transporter-permease
MHNERSLAFKVTWLLVSAIVLSLVMLSSVMFGIQTYSWEQIVAAYSRFDGSNEHLIITTARMPRALIAAAVGASLAVAGALMQAITRNPLASPSVFGVNAGAAFAIVLSVTVWNASSLSEFVWIAFAGAAISSLAVYVLGSIGRDGLTPMKITLAGSAISAFFASLTQGLLLGSGKAFDQVLFWLVGSVAGRTMEMLHSVLPYMAAAMVGALLLASHINVLSMGEDVAKGLGQRTILIKALTALVIVLLAGGSVAVAGPIVFVGIIVPHIVRFVVGIDHRWVLPYCAVFGALLLTGADVGARFIAMPKEVHVGVTTAIIGVPFFVYIARKGGQLR
>NC_015690.1|WP_128759009.1|8005634_8006633_-|iron-siderophore-ABC-transporter-substrate-binding-protein
MQRFTGMIGKKSSLLLALVMMLSVFLTACGSKPAEQAAPSTAGGTENKTAAEGPRKIKHVMGETEVPAAPKRVVILTNEGTEALLSLGIKPVGAVKSWTGSPWYDHIESEMEGVTVVGEESQPNLELIASLKPDLIIGNKMRQEKVYDQLKAIAPTVFSETLRGEWKNNYRLYAETVGKKDEGEKVIADFDKRIADIKAKAGDKLNQKVSVVRFMAGKTRIYLQDTFTGIIFNQLGIKRPENKYKDTFVEEITKERLPEVDADMLFYFTYETGDNKASQQEQDWLNDPLWKNLNVVKAGKVHKVNDAIWNTAGGVKAANLMLDDLAKIYEIK
>NC_015690.1|WP_049819122.1|8018293_8019802_-|amidophosphoribosyltransferase
MRQGGNGQGQHDGAFPLWTGAYYNEGMGAGPNGLSDKLGEECGVFGVFGHPEAANLSYYGLHALQHRGQESSGICVAGEDAFNYHRGMGLVKEVFNNDNLGPMVGSYAIGHVRYSTAGESKLANAQPLVFKYREGDLAIATNGNLTNAPDIKKRLEREGSIFQTTSDTEVVAHLIARSKHDDIVEAVRDALLQIEGAYAFLFLTRDKLIAARDPHGLRPFVMGRLGDAYLFASESCAFDTVGGLYERDIQPGELLILNQRTGELTHDRFAEGKQRAVCAMEYIYFARPDSDIDEVNIHSARKRMGRQLAIESFVDADIVTGVPDSSISAAIGYAEQTGIPYELGLIKNRYTGRTFIQPSQELREQGVKMKLSAVRSIVQGKRVVMIDDSIVRGTTSLRIVNMLREAGATEVHVRISSPPFQNPCFYGIDTPNRGELIAAVKSVEEIRKAINADSLHFLSQEGLVNSIGGPAGEINRGHCTACFDNRYPTAIPDDAKIGCGCD
>NC_015690.1|WP_013920974.1|8019858_8022105_-|phosphoribosylformylglycinamidine-synthase-subunit-PurL
MAQQLSAKEPTAEQIQEQKIYKQFGVSDAEYDLICGFLGRKPNYVEIGVFSVMWSEHCSYKNSKAVLRKFPTTGERVLMGPGEGAGIVDIGDNQAVVFKIESHNHPSAVEPYQGAATGVGGIIRDIFSMGARPVAVLNSLRFGRLTNDRVKYLFEHVVSGIAGYGNCIGIPTVGGEVMFDESYEGNPLVNAMCVGIIDHDKIQKGVAKGVGNPVFYVGPATGRDGIHGATFASEDLTAESEAKRSAVQVGDPFMEKLVLEACLELIDSGIVVGIQDMGAAGLTCSSSEMASKAGNGMELYLDEVPQREEGMTPYEMMLSESQERMLFVVKPEHEEQAKAIFERWGLHCAKVGKVTDDGNLKLYHKGELVGDMPVTALVDECPMYNKPSSVPAYYEANASVDTTAYPEVTDLNGALKQVLASPTVASKEWVYNQYDYMVRTSTAVQPGSDAAVVTIRGSRKALSMSTDCNGRYVYLDPEVGGKIAVAEAARNNVCSGAEPLAITDNLNFGSPEKPEIFWQLEKSVDGMAEACRKLNTPVIGGNVSLYNENARGAIYPTPVVGMVGLVHDTDHITTQGFKNEGDIVLLLGETKAELGGSEFQYVVHGVTEGRPPQIDLDVEKTLLDTVLGAIQKGLVASAHDLSDGGLAVALAESCISGRLGANVNLTTDLRADIALFSESQSRLLLSAAPEKASELEAVLKAAGVPVQVIGKVEGTSLQVQVNGSAAIDAAVAELQQVWKDAIPCLMNA
>NC_015690.1|WP_013920975.1|8022082_8022778_-|phosphoribosylformylglycinamidine-synthase-subunit-PurQ
MNFAVLVFPGSNCDIDCYKAVEDTVGQPVDYVWHTETDLSKYDCIIIPGGFSYGDYLRCGAIAQFAPVMKALREAAEQGKYILGICNGFQILLESGLLPGAMLRNESLKFRCHAAMLSVVNTDTPFTKEYKQDELINIPIAHGEGNYYCDEAALAELKANNQIVFRYEAGNNPNGSVDDIAGICSKGGNVLGMMPHPERAVSALLGSEDGKRMFTSILSTWREKHGAAAIG
>NC_015690.1|WP_013920976.1|8022824_8023070_-|phosphoribosylformylglycinamidine-synthase-subunit-PurS
MLKATVYVTIKQSVLDVQGTAVQGALHSMGFDEVDKVRIGKYLEVELNTDNRAAAEERLKAMCEKLLANTVIEDYRYELSE
>NC_015690.1|WP_013920977.1|8023185_8024079_-|phosphoribosylaminoimidazolesuccinocarboxamide-synthase
MKEASTIAISSAQEYIKAPLLYKGKVREIYGLGDHYLIAVSDRISAFDWVLSPAVPDKGNVLNTLSKFWFDQTTEIIDNHVVHTDVDLLGDIITDREIMKDRFMVTKKAERIDIECVVRGYITGGGWRQYQQTGEINGHKLPAGLRKNQRFEQPIFTPAAKNDVGHDEDISIERMKELVGAELTEQLQAKSLQLYNYAHAFCQDRGIILADTKFEFGLIDGEIILIDEIFTPDSSRFWAKDKYELDTEIDSMDKEPVRSYLASTDWDKNSEPAPLPAEVVEETSRRYREIYNRLVLG
>NC_015690.1|WP_013920978.1|8024112_8025408_-|adenylosuccinate-lyase
MIDRYTRPEMGSIWTEENKFKAWLEVEILSCEAWAELGVIPKEDVAELRKNASFDIDRIYEIEQETRHDVIAFTRAVSEKVGPERKWVHYGLTSTDVVDTALGYLLRQANEIIERDIVNFIEILKDKAVAYKDTPMMGRTHGVHAEPTTFGLKMALWYEEMKRNLERFRFAADGVQFGKISGAVGTYANIDPFIEEYVCGKLGTKPAPISTQTLQRDRHAEYMATLALIATSLDKFATEIRALQKSEFREVEEPFAKGQKGSSAMPHKRNPIGCESISGLARVIRGHMVSAYENVTLWHERDISHSSVERIILPDSTILLNYMLNRLGNIIKNLTVFPENMKRNMQSTYGVPFSGRVMTKLIDKGLSREQAYDTVQPRAMQAWEEQRSFRDIVENTPAIREYLSLEEIEDAFNPSWHLKHVDTIFKRLGLS
>NC_015690.1|WP_013920979.1|8025457_8026654_-|5-(carboxyamino)imidazole-ribonucleotide-synthase
MTMNEANKNRPYDPLKVTPPGSVIGVLGGGQLGRMLALAGKAMGYRFVTLDPTPDAPCGQVADRQIVAAYDDAAAARTLAEEADVITYEFENVDAGVTELLMRESYVPQGSELLYTTQHRLREKRAIEAAGVKVAPYAEVASAAELREAVERFGTPCVLKTATGGYDGKGQWVIRSLDEVEEAFETLSRAKTELVLEQFIRFEREISVIAARSPRGEVKAFPPAENIHVNNILHLSIVPARAPEGVLKRAEEMALQIAEKLDVIGLIAVEMFLTSDGELFVNELAPRPHNSGHYTMEACRTSQFEQHLRAVCNLPLGDPSLLVPVVMVNVLGEHVAPLLEWIQNPESQSAVPGVTAKLHLYGKEEAKAGRKMGHVNLLADRAEDAFRWIELSGVWESK
>NC_015690.1|WP_013920980.1|8026650_8027136_-|5-(carboxyamino)imidazole-ribonucleotide-mutase
MSVLVGVIMGSQSDWETMKKACDVLDELGVAYEKKVVSAHRTPDLMFEYAETAAERGLKVIIAGAGGAAHLPGMVASKTVLPVIGVPVKTSTLNGLDSLLSIVQMPGGIPVATVAIGQAGATNAGLLAAQILGAFDGGIQQRVAERRERIAKSVMESSVLE
>NC_015690.1|WP_013920981.1|8027556_8028249_-|hypothetical-protein
MYQRDYILRMIEQAGVMVGRVMHLARNKRMQEAVELLQQAMKEMLGLGSKLIGALSVKDLIALLSKDGELDSAKVLALGDLMKAQSELQREGGEEAAAQRTAKKSLELLLIGREYDARGELREEFNRRIEEALDITGRAGLNEGILSRIVGYYEEQGSYAWAEDALFYRLEVLQGAGRELERRAVVEEGIRMYERWVLLEDATLQAGGLSAEEAEEGLRTLRQLKITQSQ
>NC_015690.1|WP_013920982.1|8028657_8029500_+|hypothetical-protein
MNSRITSMLKACLLTLPAAAILVFASPAQAETVRLAEDIKVQVNSSLVHFPDAQPFLDENHKLQVPARVMADKLGYQLQWEHAGAQMKVTLSSSTTTVVFTTGDPNITVNGQPSVQEAAAKLVDGRAYVPFRMLADSFSIQTQWDNLNRIAILGVDGQYHAPAWYRPTKIAPLYTKTIEARASAYTAAAAENGTFAARDYMGNPLKLGTIAVDPAVIPLGSKVFIEGYTHDGLPVGGMYAVATDIGGSVKGNKIDIFMPQGRHAALQFGIQNVKVHVLGS

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_015690_15	15.1\|2739687\|41\|NC_015690\|PILER-CR	2739687-2739727	41	NC_015690.1	2739574-2739614	0	1.0
NC_015690_22	22.1\|6921666\|27\|NC_015690\|CRISPRCasFinder	6921666-6921692	27	NC_015690.1	2472434-2472460	1	0.963
NC_015690_22	22.1\|6921666\|27\|NC_015690\|CRISPRCasFinder	6921666-6921692	27	NC_015690.1	2540841-2540867	1	0.963
NC_015690_3	3.1\|1004733\|41\|NC_015690\|PILER-CR	1004733-1004773	41	NC_015690.1	1004960-1005000	2	0.951
NC_015690_3	3.2\|1004794\|32\|NC_015690\|PILER-CR	1004794-1004825	32	NC_015690.1	1004681-1004712	2	0.938
NC_015690_3	3.2\|1004794\|32\|NC_015690\|PILER-CR	1004794-1004825	32	NC_015690.1	1005021-1005052	2	0.938
NC_015690_15	15.3\|2739800\|41\|NC_015690\|PILER-CR	2739800-2739840	41	NC_015690.1	2739461-2739501	2	0.951

1. spacer 15.1|2739687|41|NC_015690|PILER-CR matches to position: 2739574-2739614, mismatch: 0, identity: 1.0

cggcgccgcattgaggcttcagccgctgctttgctccctcg	CRISPR spacer
cggcgccgcattgaggcttcagccgctgctttgctccctcg	Protospacer
*****************************************

2. spacer 22.1|6921666|27|NC_015690|CRISPRCasFinder matches to position: 2472434-2472460, mismatch: 1, identity: 0.963

tcgactatttcccatcatttcccgaag	CRISPR spacer
tcggctatttcccatcatttcccgaag	Protospacer
***.***********************

3. spacer 22.1|6921666|27|NC_015690|CRISPRCasFinder matches to position: 2540841-2540867, mismatch: 1, identity: 0.963

tcgactatttcccatcatttcccgaag	CRISPR spacer
tcgagtatttcccatcatttcccgaag	Protospacer
**** **********************

4. spacer 3.1|1004733|41|NC_015690|PILER-CR matches to position: 1004960-1005000, mismatch: 2, identity: 0.951

gatgagcgggagtgcgccctgaagcgcagcagcgatgggtt	CRISPR spacer
gatgagcgggagtgcgccctgaagcgcagcagcgacggatt	Protospacer
***********************************.**.**

5. spacer 3.2|1004794|32|NC_015690|PILER-CR matches to position: 1004681-1004712, mismatch: 2, identity: 0.938

ggtagtgagcagccgttcttcggtggccccgg	CRISPR spacer
ggtagtgagcagccggtcttcggtggctccgg	Protospacer
*************** ***********.****

6. spacer 3.2|1004794|32|NC_015690|PILER-CR matches to position: 1005021-1005052, mismatch: 2, identity: 0.938

ggtagtgagcagccgttcttcggtggccccgg	CRISPR spacer
ggtagtgagcagccggtcttcggtggctccgg	Protospacer
*************** ***********.****

7. spacer 15.3|2739800|41|NC_015690|PILER-CR matches to position: 2739461-2739501, mismatch: 2, identity: 0.951

cggcaccgcatcgagccgtcagccgctgctttactccttcg	CRISPR spacer
cggcaacgcatcgagccttcagccgctgctttactccttcg	Protospacer
***** *********** ***********************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_015690_7	7.1\|1421740\|25\|NC_015690\|CRISPRCasFinder	1421740-1421764	25	NZ_CP016453	Sphingobium sp. RAC03 plasmid pBSY17_1, complete sequence	696812-696836	4	0.84
NC_015690_17	17.1\|3117908\|26\|NC_015690\|CRISPRCasFinder	3117908-3117933	26	MK733259	Yersinia phage YeP1, complete genome	13094-13119	4	0.846
NC_015690_17	17.1\|3117908\|26\|NC_015690\|CRISPRCasFinder	3117908-3117933	26	MK733261	Yersinia phage YeP3, complete genome	13105-13130	4	0.846
NC_015690_17	17.1\|3117908\|26\|NC_015690\|CRISPRCasFinder	3117908-3117933	26	MK733260	Yersinia phage YeP2, complete genome	13105-13130	4	0.846
NC_015690_16	16.1\|3026510\|30\|NC_015690\|CRISPRCasFinder	3026510-3026539	30	NC_015708	Pseudoalteromonas sp. SANK 73390 plasmid pTML1 carrying thiomarinol biosynthesis cluster	75021-75050	5	0.833
NC_015690_20	20.1\|6768497\|27\|NC_015690\|CRISPRCasFinder	6768497-6768523	27	NZ_CP031696	Erwinia billingiae strain TH88 plasmid unnamed1, complete sequence	18250-18276	6	0.778
NC_015690_22	22.1\|6921666\|27\|NC_015690\|CRISPRCasFinder	6921666-6921692	27	NZ_CP032306	Salmonella enterica subsp. enterica serovar Braenderup strain FORC93 plasmid unnamed2, complete sequence	21493-21519	6	0.778
NC_015690_13	13.5\|2523835\|33\|NC_015690\|CRT	2523835-2523867	33	MN103401	Bordetella phage vB_BbrS_PHB09, complete genome	7149-7181	7	0.788
NC_015690_15	15.2\|2739749\|30\|NC_015690\|PILER-CR	2739749-2739778	30	JQ768459	Pseudomonas phage Lu11, complete genome	230676-230705	7	0.767
NC_015690_15	15.2\|2739749\|30\|NC_015690\|PILER-CR	2739749-2739778	30	MN694663	Marine virus AFVG_250M439, complete genome	42895-42924	7	0.767
NC_015690_18	18.1\|3596939\|28\|NC_015690\|CRISPRCasFinder	3596939-3596966	28	NZ_CP028099	Synechocystis sp. IPPAS B-1465 plasmid pSYSM, complete sequence	47461-47488	7	0.75
NC_015690_18	18.1\|3596939\|28\|NC_015690\|CRISPRCasFinder	3596939-3596966	28	NC_005229	Synechocystis sp. PCC 6803 plasmid pSYSM, complete sequence	47461-47488	7	0.75
NC_015690_18	18.1\|3596939\|28\|NC_015690\|CRISPRCasFinder	3596939-3596966	28	MG962376	Mycobacterium phage Thumb, complete genome	34432-34459	7	0.75
NC_015690_18	18.1\|3596939\|28\|NC_015690\|CRISPRCasFinder	3596939-3596966	28	KJ567046	Mycobacterium phage Damien, complete genome	34435-34462	7	0.75
NC_015690_18	18.1\|3596939\|28\|NC_015690\|CRISPRCasFinder	3596939-3596966	28	MN010756	Mycobacterium phage Phreeze, complete genome	34435-34462	7	0.75
NC_015690_18	18.1\|3596939\|28\|NC_015690\|CRISPRCasFinder	3596939-3596966	28	NC_023578	Mycobacterium phage Oaker, complete genome	34692-34719	7	0.75
NC_015690_18	18.1\|3596939\|28\|NC_015690\|CRISPRCasFinder	3596939-3596966	28	MT521996	Mycobacterium phage Beckerton, complete genome	34969-34996	7	0.75
NC_015690_18	18.1\|3596939\|28\|NC_015690\|CRISPRCasFinder	3596939-3596966	28	MH509445	Mycobacterium phage Cborch11, complete genome	34434-34461	7	0.75
NC_015690_18	18.1\|3596939\|28\|NC_015690\|CRISPRCasFinder	3596939-3596966	28	NC_011292	Mycobacterium phage Konstantine, complete genome	35636-35663	7	0.75
NC_015690_15	15.2\|2739749\|30\|NC_015690\|PILER-CR	2739749-2739778	30	NZ_CP049158	Caballeronia sp. SBC1 plasmid pSBC1_2, complete sequence	1134762-1134791	8	0.733
NC_015690_15	15.2\|2739749\|30\|NC_015690\|PILER-CR	2739749-2739778	30	NZ_CP049318	Caballeronia sp. SBC2 plasmid pSBC2-2, complete sequence	1139442-1139471	8	0.733
NC_015690_3	3.2\|1004794\|32\|NC_015690\|PILER-CR	1004794-1004825	32	KT591491	Mycobacterium phage Bricole, complete genome	21887-21918	9	0.719
NC_015690_3	3.2\|1004794\|32\|NC_015690\|PILER-CR	1004794-1004825	32	NC_021299	Mycobacterium phage PegLeg, complete genome	21900-21931	9	0.719
NC_015690_3	3.2\|1004794\|32\|NC_015690\|PILER-CR	1004794-1004825	32	MN586024	Mycobacterium phage TyDawg, complete genome	21901-21932	9	0.719
NC_015690_3	3.2\|1004794\|32\|NC_015690\|PILER-CR	1004794-1004825	32	MK937612	Mycobacterium phage LilhomieP, complete genome	21901-21932	9	0.719
NC_015690_3	3.2\|1004794\|32\|NC_015690\|PILER-CR	1004794-1004825	32	MH697587	Mycobacterium phage IPhane7, complete genome	21901-21932	9	0.719
NC_015690_3	3.2\|1004794\|32\|NC_015690\|PILER-CR	1004794-1004825	32	NC_041970	Mycobacterium phage Bongo, complete genome	21901-21932	9	0.719
NC_015690_13	13.9\|2524061\|32\|NC_015690\|CRT	2524061-2524092	32	NZ_CP034185	Deinococcus sp. S14-83 strain S14-83T plasmid unnamed1, complete sequence	225596-225627	9	0.719
NC_015690_13	13.3\|2523722\|33\|NC_015690\|CRT	2523722-2523754	33	NZ_CP034185	Deinococcus sp. S14-83 strain S14-83T plasmid unnamed1, complete sequence	225596-225628	10	0.697
NC_015690_13	13.7\|2523948\|33\|NC_015690\|CRT	2523948-2523980	33	NZ_CP034185	Deinococcus sp. S14-83 strain S14-83T plasmid unnamed1, complete sequence	225596-225628	10	0.697

1. spacer 7.1|1421740|25|NC_015690|CRISPRCasFinder matches to NZ_CP016453 (Sphingobium sp. RAC03 plasmid pBSY17_1, complete sequence) position: , mismatch: 4, identity: 0.84

ttaacctgccctgggcagataggtg	CRISPR spacer
gcaaccggcgctgggcagataggtg	Protospacer
 .**** ** ***************

2. spacer 17.1|3117908|26|NC_015690|CRISPRCasFinder matches to MK733259 (Yersinia phage YeP1, complete genome) position: , mismatch: 4, identity: 0.846

cgggctgatgtgaagcgcgatattcg	CRISPR spacer
cgtgctgatgtgaatcgcgatatcag	Protospacer
** *********** ********. *

3. spacer 17.1|3117908|26|NC_015690|CRISPRCasFinder matches to MK733261 (Yersinia phage YeP3, complete genome) position: , mismatch: 4, identity: 0.846

cgggctgatgtgaagcgcgatattcg	CRISPR spacer
cgtgctgatgtgaatcgcgatatcag	Protospacer
** *********** ********. *

4. spacer 17.1|3117908|26|NC_015690|CRISPRCasFinder matches to MK733260 (Yersinia phage YeP2, complete genome) position: , mismatch: 4, identity: 0.846

cgggctgatgtgaagcgcgatattcg	CRISPR spacer
cgtgctgatgtgaatcgcgatatcag	Protospacer
** *********** ********. *

5. spacer 16.1|3026510|30|NC_015690|CRISPRCasFinder matches to NC_015708 (Pseudoalteromonas sp. SANK 73390 plasmid pTML1 carrying thiomarinol biosynthesis cluster) position: , mismatch: 5, identity: 0.833

ttaatacagagcgagatatttcattttgaa	CRISPR spacer
ttctttcagctcgagatatttcattttgaa	Protospacer
**  * ***  *******************

6. spacer 20.1|6768497|27|NC_015690|CRISPRCasFinder matches to NZ_CP031696 (Erwinia billingiae strain TH88 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.778

ccggttatttcccgttatttcccggag	CRISPR spacer
tacattattgcccgctatttcccggag	Protospacer
.  .***** ****.************

7. spacer 22.1|6921666|27|NC_015690|CRISPRCasFinder matches to NZ_CP032306 (Salmonella enterica subsp. enterica serovar Braenderup strain FORC93 plasmid unnamed2, complete sequence) position: , mismatch: 6, identity: 0.778

tcgactatttcccatcatttcccgaag	CRISPR spacer
tattgtatttcccatgatttcccgaat	Protospacer
*    ********** **********

8. spacer 13.5|2523835|33|NC_015690|CRT matches to MN103401 (Bordetella phage vB_BbrS_PHB09, complete genome) position: , mismatch: 7, identity: 0.788

agcggccaatccgcccccagcaagctggctaac	CRISPR spacer
aaagcccaatccaccgccagcaagctggccgac	Protospacer
*. * *******.** *************..**

9. spacer 15.2|2739749|30|NC_015690|PILER-CR matches to JQ768459 (Pseudomonas phage Lu11, complete genome) position: , mismatch: 7, identity: 0.767

gagcggcaaatgcagcgaataaaccggttt	CRISPR spacer
tggcagaaaatgcagcgaataaaccgcgta	Protospacer
 .**.* *******************  *

10. spacer 15.2|2739749|30|NC_015690|PILER-CR matches to MN694663 (Marine virus AFVG_250M439, complete genome) position: , mismatch: 7, identity: 0.767

gagcggcaaatgcagcgaataaaccggttt-	CRISPR spacer
tagcggcaaatgcagctaat-aattggtcaa	Protospacer
 *************** *** **..***.

11. spacer 18.1|3596939|28|NC_015690|CRISPRCasFinder matches to NZ_CP028099 (Synechocystis sp. IPPAS B-1465 plasmid pSYSM, complete sequence) position: , mismatch: 7, identity: 0.75

ttgttgggaaatgacgggaaataccggg	CRISPR spacer
ttgttgggaaattacgggaaacatgacc	Protospacer
************ ********.*. .

12. spacer 18.1|3596939|28|NC_015690|CRISPRCasFinder matches to NC_005229 (Synechocystis sp. PCC 6803 plasmid pSYSM, complete sequence) position: , mismatch: 7, identity: 0.75

ttgttgggaaatgacgggaaataccggg	CRISPR spacer
ttgttgggaaattacgggaaacatgacc	Protospacer
************ ********.*. .

13. spacer 18.1|3596939|28|NC_015690|CRISPRCasFinder matches to MG962376 (Mycobacterium phage Thumb, complete genome) position: , mismatch: 7, identity: 0.75

ttgttgggaaatgacgggaaataccggg	CRISPR spacer
ctgttcggaaacgacgggaaatacatcc	Protospacer
.**** *****.************

14. spacer 18.1|3596939|28|NC_015690|CRISPRCasFinder matches to KJ567046 (Mycobacterium phage Damien, complete genome) position: , mismatch: 7, identity: 0.75

ttgttgggaaatgacgggaaataccggg	CRISPR spacer
ctgttcggaaacgacgggaaatacatcc	Protospacer
.**** *****.************

15. spacer 18.1|3596939|28|NC_015690|CRISPRCasFinder matches to MN010756 (Mycobacterium phage Phreeze, complete genome) position: , mismatch: 7, identity: 0.75

ttgttgggaaatgacgggaaataccggg	CRISPR spacer
ctgttcggaaacgacgggaaatacatcc	Protospacer
.**** *****.************

16. spacer 18.1|3596939|28|NC_015690|CRISPRCasFinder matches to NC_023578 (Mycobacterium phage Oaker, complete genome) position: , mismatch: 7, identity: 0.75

ttgttgggaaatgacgggaaataccggg	CRISPR spacer
ctgttcggaaacgacgggaaatacatcc	Protospacer
.**** *****.************

17. spacer 18.1|3596939|28|NC_015690|CRISPRCasFinder matches to MT521996 (Mycobacterium phage Beckerton, complete genome) position: , mismatch: 7, identity: 0.75

ttgttgggaaatgacgggaaataccggg	CRISPR spacer
ctgttcggaaacgacgggaaatacatcc	Protospacer
.**** *****.************

18. spacer 18.1|3596939|28|NC_015690|CRISPRCasFinder matches to MH509445 (Mycobacterium phage Cborch11, complete genome) position: , mismatch: 7, identity: 0.75

ttgttgggaaatgacgggaaataccggg	CRISPR spacer
ctgttcggaaacgacgggaaatacatcc	Protospacer
.**** *****.************

19. spacer 18.1|3596939|28|NC_015690|CRISPRCasFinder matches to NC_011292 (Mycobacterium phage Konstantine, complete genome) position: , mismatch: 7, identity: 0.75

ttgttgggaaatgacgggaaataccggg	CRISPR spacer
ctgttcggaaacgacgggaaatacatcc	Protospacer
.**** *****.************

20. spacer 15.2|2739749|30|NC_015690|PILER-CR matches to NZ_CP049158 (Caballeronia sp. SBC1 plasmid pSBC1_2, complete sequence) position: , mismatch: 8, identity: 0.733

gagcggcaaatgcagcgaataaaccggttt	CRISPR spacer
catccacaaatgcagcgaatacaccggcgc	Protospacer
 * * .*************** *****. .

21. spacer 15.2|2739749|30|NC_015690|PILER-CR matches to NZ_CP049318 (Caballeronia sp. SBC2 plasmid pSBC2-2, complete sequence) position: , mismatch: 8, identity: 0.733

gagcggcaaatgcagcgaataaaccggttt	CRISPR spacer
catccacaaatgcagcgaatacaccggcgc	Protospacer
 * * .*************** *****. .

22. spacer 3.2|1004794|32|NC_015690|PILER-CR matches to KT591491 (Mycobacterium phage Bricole, complete genome) position: , mismatch: 9, identity: 0.719

ggtagtgagcagccgttcttcggtggccccgg	CRISPR spacer
gcggctgagctgccgttcttcgttggcccttc	Protospacer
*  . ***** *********** ******.

23. spacer 3.2|1004794|32|NC_015690|PILER-CR matches to NC_021299 (Mycobacterium phage PegLeg, complete genome) position: , mismatch: 9, identity: 0.719

ggtagtgagcagccgttcttcggtggccccgg	CRISPR spacer
gcggctgagctgccgttcttcgttggcccttc	Protospacer
*  . ***** *********** ******.

24. spacer 3.2|1004794|32|NC_015690|PILER-CR matches to MN586024 (Mycobacterium phage TyDawg, complete genome) position: , mismatch: 9, identity: 0.719

ggtagtgagcagccgttcttcggtggccccgg	CRISPR spacer
gcggctgagctgccgttcttcgttggcccttc	Protospacer
*  . ***** *********** ******.

25. spacer 3.2|1004794|32|NC_015690|PILER-CR matches to MK937612 (Mycobacterium phage LilhomieP, complete genome) position: , mismatch: 9, identity: 0.719

ggtagtgagcagccgttcttcggtggccccgg	CRISPR spacer
gcggctgagctgccgttcttcgttggcccttc	Protospacer
*  . ***** *********** ******.

26. spacer 3.2|1004794|32|NC_015690|PILER-CR matches to MH697587 (Mycobacterium phage IPhane7, complete genome) position: , mismatch: 9, identity: 0.719

ggtagtgagcagccgttcttcggtggccccgg	CRISPR spacer
gcggctgagctgccgttcttcgttggcccttc	Protospacer
*  . ***** *********** ******.

27. spacer 3.2|1004794|32|NC_015690|PILER-CR matches to NC_041970 (Mycobacterium phage Bongo, complete genome) position: , mismatch: 9, identity: 0.719

ggtagtgagcagccgttcttcggtggccccgg	CRISPR spacer
gcggctgagctgccgttcttcgttggcccttc	Protospacer
*  . ***** *********** ******.

28. spacer 13.9|2524061|32|NC_015690|CRT matches to NZ_CP034185 (Deinococcus sp. S14-83 strain S14-83T plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.719

agcggccaatccgccctcggcaggccggcgaa	CRISPR spacer
cgcggccaattcgcgctcggcaggcagagcgc	Protospacer
 *********.*** ********** *.  .

29. spacer 13.3|2523722|33|NC_015690|CRT matches to NZ_CP034185 (Deinococcus sp. S14-83 strain S14-83T plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.697

agcggccaatccgccctcggcaggccggcgaac	CRISPR spacer
cgcggccaattcgcgctcggcaggcagagcgct	Protospacer
 *********.*** ********** *.  . .

30. spacer 13.7|2523948|33|NC_015690|CRT matches to NZ_CP034185 (Deinococcus sp. S14-83 strain S14-83T plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.697

agcggccaatccgccctcggcaggccggcgaac	CRISPR spacer
cgcggccaattcgcgctcggcaggcagagcgct	Protospacer
 *********.*** ********** *.  . .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1193674 : 1234291

Bacillus_phage(40.91%)

portal,tail,terminase,capsid,coat,transposase,head,integrase,protease

attL 1185896:1185911|attR 1209439:1209454

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1185896:1185911	attL	NA	NA	NA	NA
WP_013914915.1\|1193674_1193878_+\|coat	spore coat associated protein CotJA	NA	NA	NA	NA
WP_013914916.1\|1193898_1194165_+\|coat	spore coat protein CotJB	NA	NA	NA	NA
WP_013914917.1\|1194201_1194426_+	manganese catalase family protein	NA	NA	NA	NA
WP_013914918.1\|1194525_1196112_-	recombinase family protein	R9W007	Paenibacillus_phage	9.1e-131	48.4
WP_013914919.1\|1196280_1197699_+	TIR domain-containing protein	NA	NA	NA	NA
WP_187296722.1\|1197785_1197962_+	hypothetical protein	NA	NA	NA	NA
WP_041616549.1\|1197943_1198318_-	helix-turn-helix domain-containing protein	S6C481	Thermus_phage	1.9e-18	50.0
WP_013914923.1\|1198472_1198721_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_041616551.1\|1198742_1199072_+	hypothetical protein	NA	NA	NA	NA
WP_013914925.1\|1199226_1199724_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_041616552.1\|1199713_1199989_+	hypothetical protein	NA	NA	NA	NA
WP_013914926.1\|1199966_1200350_+	DUF2538 family protein	NA	NA	NA	NA
WP_013914927.1\|1200572_1201604_+	DnaD domain protein	A0A0K2CY85	Paenibacillus_phage	2.7e-30	57.5
WP_013914928.1\|1201584_1201923_+	hypothetical protein	NA	NA	NA	NA
WP_013914929.1\|1201934_1202162_+	hypothetical protein	NA	NA	NA	NA
WP_041616553.1\|1202176_1202629_+	hypothetical protein	NA	NA	NA	NA
WP_013914930.1\|1202644_1202896_+	hypothetical protein	NA	NA	NA	NA
WP_013914931.1\|1202885_1203116_+	preprotein translocase subunit YajC	NA	NA	NA	NA
WP_143768101.1\|1204847_1205168_-	hypothetical protein	NA	NA	NA	NA
WP_013914933.1\|1205704_1206082_+	hypothetical protein	NA	NA	NA	NA
WP_013914935.1\|1206811_1207384_+\|integrase	tyrosine-type recombinase/integrase	D2XR58	Bacillus_phage	9.2e-41	47.3
WP_013914936.1\|1207559_1208951_+	hypothetical protein	NA	NA	NA	NA
WP_041616556.1\|1209442_1209793_+	HNH endonuclease	A0A0K2CYS9	Paenibacillus_phage	7.9e-19	48.9
1209439:1209454	attR	NA	NA	NA	NA
WP_041616557.1\|1210498_1210840_+	hypothetical protein	NA	NA	NA	NA
WP_013914939.1\|1210848_1211388_+	hypothetical protein	NA	NA	NA	NA
WP_143768191.1\|1211627_1212164_+\|terminase	phage terminase small subunit P27 family	Q9ZXG2	Bacillus_phage	1.1e-51	63.0
WP_013914941.1\|1212163_1213888_+\|terminase	terminase large subunit	A6M948	Geobacillus_virus	4.5e-176	53.7
WP_013914942.1\|1213920_1215186_+\|portal	phage portal protein	A0A0U3SQF0	Bacillus_phage	5.3e-81	46.7
WP_041616560.1\|1215142_1215847_+\|head,protease	HK97 family phage prohead protease	E2ELI4	Clostridium_phage	4.2e-35	50.9
WP_013914943.1\|1215848_1217015_+\|capsid	phage major capsid protein	A0A1B1P7R4	Bacillus_phage	1.6e-100	49.6
WP_013914944.1\|1217031_1217343_+\|head,tail	phage gp6-like head-tail connector protein	NA	NA	NA	NA
WP_041616563.1\|1217519_1217879_+\|head	phage head closure protein	A6M954	Geobacillus_virus	9.9e-17	35.9
WP_041616564.1\|1217838_1218231_+	HK97 gp10 family phage protein	W8CZ44	Bacillus_phage	4.2e-21	42.5
WP_013914947.1\|1218227_1218587_+	DUF3168 domain-containing protein	A0A2H4JAR3	uncultured_Caudovirales_phage	1.6e-27	52.2
WP_013914948.1\|1218589_1219219_+\|tail	tail protein	A0A0K2CZP8	Paenibacillus_phage	2.8e-30	38.0
WP_041616566.1\|1219245_1219647_+	hypothetical protein	A0A0S2SXM1	Bacillus_phage	4.8e-20	43.6
WP_013914950.1\|1219633_1221244_+	fibronectin type III domain-containing protein	A0A2D1GD28	Mycobacterium_phage	8.4e-07	34.6
WP_013914951.1\|1221300_1221603_+	hypothetical protein	A0A288WFU2	Bacillus_phage	8.3e-09	35.5
WP_013914952.1\|1221798_1226235_+\|tail	phage tail tape measure protein	A0A0S2SXL7	Bacillus_phage	7.6e-74	34.6
WP_013914953.1\|1226227_1227079_+\|tail	phage tail family protein	A0A0K2CZA8	Paenibacillus_phage	2.1e-41	33.3
WP_013914954.1\|1227081_1228209_+	siphovirus ReqiPepy6 Gp37-like family protein	A0A0K2CZQ1	Paenibacillus_phage	2.1e-52	33.9
WP_013914955.1\|1228210_1229920_+	hypothetical protein	NA	NA	NA	NA
WP_041616568.1\|1229932_1230211_+	hypothetical protein	NA	NA	NA	NA
WP_013914957.1\|1230230_1230374_+	hypothetical protein	NA	NA	NA	NA
WP_013914958.1\|1230496_1230766_+	hypothetical protein	NA	NA	NA	NA
WP_013914959.1\|1230776_1232168_+	phosphodiester glycosidase family protein	Q9ZXD7	Bacillus_phage	1.2e-17	36.9
WP_013914960.1\|1232170_1232566_+	hypothetical protein	NA	NA	NA	NA
WP_013914961.1\|1232777_1232918_+	hypothetical protein	NA	NA	NA	NA
WP_013914962.1\|1233067_1234291_-\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	5.7e-56	51.6

DBSCAN-SWA_2

2857563 : 2867999

Staphylococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013916445.1\|2857563_2857995_+	peptidylprolyl isomerase	A0A1B1IVS0	uncultured_Mediterranean_phage	4.2e-22	43.7
WP_041616865.1\|2858594_2859707_+	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	6.3e-54	40.3
WP_013916447.1\|2859745_2860414_+	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	7.0e-40	44.4
WP_013916448.1\|2860478_2861717_+	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	9.3e-115	53.0
WP_013916449.1\|2861753_2862224_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	5.8e-41	57.4
WP_013916450.1\|2862266_2863052_+	segregation/condensation protein A	A0A1B1IVW1	uncultured_Mediterranean_phage	6.3e-08	35.6
WP_013916451.1\|2863020_2863638_+	SMC-Scp complex subunit ScpB	A0A1B1IVT7	uncultured_Mediterranean_phage	1.4e-15	35.6
WP_013916452.1\|2863760_2864444_+	DUF2953 domain-containing protein	NA	NA	NA	NA
WP_013916453.1\|2864592_2865099_+	GerW family sporulation protein	NA	NA	NA	NA
WP_013916454.1\|2865533_2867999_+	EAL domain-containing protein	G3MA91	Bacillus_virus	9.8e-23	35.6

DBSCAN-SWA_3

4343462 : 4427785

Feldmannia_irregularis_virus(25.0%)

transposase,coat

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013917876.1\|4343462_4343735_-\|coat	spore coat protein CotJB	NA	NA	NA	NA
WP_013917877.1\|4343739_4343979_-\|coat	spore coat associated protein CotJA	NA	NA	NA	NA
WP_013917878.1\|4344205_4346440_-	transglutaminase domain-containing protein	NA	NA	NA	NA
WP_013917879.1\|4346436_4347681_-	DUF58 domain-containing protein	NA	NA	NA	NA
WP_013917880.1\|4347685_4348645_-	MoxR family ATPase	NA	NA	NA	NA
WP_041617897.1\|4348960_4349326_-	stage V sporulation protein AE	NA	NA	NA	NA
WP_013917882.1\|4349330_4350353_-	stage V sporulation protein AD	NA	NA	NA	NA
WP_013917883.1\|4350356_4350836_-	stage V sporulation protein AC	NA	NA	NA	NA
WP_013917884.1\|4350862_4351729_-	DUF421 domain-containing protein	NA	NA	NA	NA
WP_013917885.1\|4352196_4352361_+	DUF1328 domain-containing protein	NA	NA	NA	NA
WP_013917886.1\|4352593_4352830_-	hypothetical protein	NA	NA	NA	NA
WP_041617898.1\|4353251_4353770_-	L,D-transpeptidase	NA	NA	NA	NA
WP_041617072.1\|4353948_4354506_-	1-acyl-sn-glycerol-3-phosphate acyltransferase	NA	NA	NA	NA
WP_013917890.1\|4354781_4355507_-	Crp/Fnr family transcriptional regulator	NA	NA	NA	NA
WP_013917891.1\|4355796_4356183_+	response regulator	Q6XM27	Feldmannia_irregularis_virus	1.0e-06	29.9
WP_013917892.1\|4356182_4357097_+	hypothetical protein	NA	NA	NA	NA
WP_041617073.1\|4359588_4359798_-	hypothetical protein	NA	NA	NA	NA
WP_013917896.1\|4359882_4360806_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_041617074.1\|4360765_4361344_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_013917897.1\|4361343_4362126_-	DUF3891 family protein	NA	NA	NA	NA
WP_013917898.1\|4362145_4362520_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_013917899.1\|4363015_4364035_+	LacI family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_013915803.1\|4364703_4366134_+\|transposase	transposase	NA	NA	NA	NA
WP_013914962.1\|4366387_4367611_+\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	5.7e-56	51.6
WP_013917900.1\|4367876_4368098_-	hypothetical protein	NA	NA	NA	NA
WP_013917901.1\|4368593_4370516_-	hypothetical protein	NA	NA	NA	NA
WP_187296683.1\|4370512_4370881_-	hypothetical protein	NA	NA	NA	NA
WP_013917902.1\|4371017_4374611_-	glycoside hydrolase family 2	NA	NA	NA	NA
WP_013917903.1\|4375087_4376602_+	alpha-L-fucosidase	NA	NA	NA	NA
WP_014370426.1\|4376716_4378420_-	hypothetical protein	NA	NA	NA	NA
WP_013917905.1\|4379000_4379810_-	polysaccharide deacetylase family protein	NA	NA	NA	NA
WP_049819053.1\|4379928_4384569_-	cellulase family glycosylhydrolase	NA	NA	NA	NA
WP_013917907.1\|4384919_4386455_-	glycoside hydrolase family 43 protein	NA	NA	NA	NA
WP_013917908.1\|4387114_4388782_-	cellulase family glycosylhydrolase	NA	NA	NA	NA
WP_013917909.1\|4389100_4392022_-	glycoside hydrolase family 3 C-terminal domain-containing protein	NA	NA	NA	NA
WP_013917910.1\|4392439_4394182_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_013917911.1\|4394213_4395107_-	carbohydrate ABC transporter permease	NA	NA	NA	NA
WP_013917912.1\|4395120_4396080_-	sugar ABC transporter permease	NA	NA	NA	NA
WP_013917913.1\|4396367_4398056_-	extracellular solute-binding protein	NA	NA	NA	NA
WP_013917914.1\|4398095_4399673_-	response regulator	NA	NA	NA	NA
WP_013917915.1\|4399665_4401474_-	sensor histidine kinase	Q9EYF3	Enterobacteria_phage	2.0e-20	27.3
WP_013917916.1\|4401985_4403851_-	polysaccharide deacetylase family protein	NA	NA	NA	NA
WP_013917917.1\|4404082_4407292_-	Ig-like domain-containing protein	NA	NA	NA	NA
WP_013917918.1\|4407527_4408472_-	carbohydrate ABC transporter permease	NA	NA	NA	NA
WP_041617080.1\|4408485_4409397_-	sugar ABC transporter permease	NA	NA	NA	NA
WP_013917921.1\|4409393_4411964_-	hypothetical protein	NA	NA	NA	NA
WP_014370438.1\|4411984_4412620_-	YIP1 family protein	NA	NA	NA	NA
WP_013917923.1\|4412600_4414067_-	SMP-30/gluconolactonase/LRE family protein	NA	NA	NA	NA
WP_014370440.1\|4414082_4414952_-	carbohydrate ABC transporter permease	NA	NA	NA	NA
WP_041617082.1\|4414960_4415917_-	sugar ABC transporter permease	NA	NA	NA	NA
WP_013917926.1\|4415934_4418769_-	extracellular solute-binding protein	NA	NA	NA	NA
WP_013917927.1\|4418914_4420327_-	extracellular solute-binding protein	NA	NA	NA	NA
WP_013917929.1\|4420892_4421756_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_081473233.1\|4422112_4422448_-	Ger(x)C family spore germination C-terminal domain-containing protein	NA	NA	NA	NA
WP_013917931.1\|4422425_4422710_-	erythromycin esterase family protein	NA	NA	NA	NA
WP_128758928.1\|4422837_4422969_-	erythromycin esterase family protein	NA	NA	NA	NA
WP_013917933.1\|4423457_4424813_+	erythromycin esterase family protein	NA	NA	NA	NA
WP_013917934.1\|4424843_4425995_+	serine hydrolase	A0A1D8EXR7	Mycobacterium_phage	3.5e-23	30.2
WP_041617084.1\|4426864_4427296_-\|transposase	transposase	NA	NA	NA	NA
WP_013917938.1\|4427353_4427785_-\|transposase	transposase	NA	NA	NA	NA

DBSCAN-SWA_4

8016045 : 8025408

Mollivirus(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014372470.1\|8016045_8017089_-	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	1.3e-72	46.8
WP_049819122.1\|8018293_8019802_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	3.1e-51	32.6
WP_013920974.1\|8019858_8022105_-	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	5.6e-166	42.5
WP_013920975.1\|8022082_8022778_-	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_013920976.1\|8022824_8023070_-	phosphoribosylformylglycinamidine synthase subunit PurS	A0A0E3FJ99	Synechococcus_phage	1.5e-08	39.2
WP_013920977.1\|8023185_8024079_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A0M4JBD3	Mollivirus	4.5e-42	32.8
WP_013920978.1\|8024112_8025408_-	adenylosuccinate lyase	A0A2H4UUU6	Bodo_saltans_virus	3.1e-20	25.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_015690

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection