CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_015756	Weissella koreensis KACC 15510 plasmid WKp2903, complete sequence	0 crisprs	csa3	0	0	0	0
NC_015759	Weissella koreensis KACC 15510, complete sequence	3 crisprs	cas3,DEDDh,WYL,csa3,DinG	2	1	2	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_015759_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015759_1

35840-36050

Orphan

Consensus_repeat	Method
AATCACTTAATGAATTACTGTCAGATAATGAATCCGACGTTGAATCGCTTGTTGATTCGCTAT	PILER-CR

2 spacers

The CRISPR arrays of NC_015759_1

>merge|NC_015759|1|35840-36050|PILER-CR
AATGAATTACTGTCGGACAATGAATCTGACGTTGAATCACTTGTTGATTCGCTATCTGAAATATTATCTGAATCACTTAATGAATTACTGTCAGATAATGAATCCGACGTTGAATCGCTTGTTGATTCGCTATCTGAAATATTATCTGAATCACTTAATGAATTACTGTCAGATAATGAATCCGACGTTGAATCGCTTGTTGATTCGCTAT

>NC_015759|1|1|35840-36050|PILER-CR
AATGAATTACTGTCGGACAATGAATCTGACGTTGAATCACTTGTTGATTCGCTATCTGAAATA	TTATCTGAATCACTT
AATGAATTACTGTCAGATAATGAATCCGACGTTGAATCGCTTGTTGATTCGCTATCTGAAATA	TTATCTGAATCACTTAATGAATTACTG
TCAGATAATGAATCCGACGTTGAATCGCTTGTTGATTCGCTAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_015759.1\|WP_013989079.1\|44524_46888_-\|preprotein-translocase-subunit-SecA	unknown	unknown	gnl\|CDD\|236408
NC_015759.1\|WP_013989077.1\|41677_43267_-\|accessory-Sec-system-protein-Asp1	unknown	unknown	gnl\|CDD\|274740
NC_015759.1\|WP_006845421.1\|38246_39323_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236626
NC_015759.1\|WP_006845428.1\|46900_47101_-\|hypothetical-protein	unknown	unknown	unknown
NC_015759.1\|WP_006845416.1\|32337_32874_-\|phenolic-acid-decarboxylase	unknown	unknown	gnl\|CDD\|368644
NC_015759.1\|WP_013989075.1\|39341_40106_-\|accessory-Sec-system-protein-Asp3	unknown	unknown	gnl\|CDD\|379726
NC_015759.1\|WP_006845411.1\|26326_27424_-\|alcohol-dehydrogenase-catalytic-domain-containing-protein	unknown	unknown	gnl\|CDD\|176188
NC_015759.1\|WP_013989080.1\|47129_48449_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274351
NC_015759.1\|WP_013989070.1\|28837_29668_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|225117
NC_015759.1\|WP_013989081.1\|48438_49920_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|131964
NC_015759.1\|WP_006845420.1\|37185_38250_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236626
NC_015759.1\|WP_013989073.1\|33120_33819_-\|Crp/Fnr-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223736
NC_015759.1\|WP_013989076.1\|40098_41685_-\|accessory-Sec-system-protein-Asp2	unknown	unknown	gnl\|CDD\|379903
NC_015759.1\|WP_006845408.1\|23765_24014_-\|hypothetical-protein	unknown	unknown	unknown
NC_015759.1\|WP_006845415.1\|31787_32336_-\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|378427
NC_015759.1\|WP_013989071.1\|29771_31571_-\|pyruvate-oxidase	unknown	unknown	gnl\|CDD\|213733
NC_015759.1\|WP_081461287.1\|43269_44496_-\|preprotein-translocase-subunit-SecY	unknown	unknown	gnl\|CDD\|237095
NC_015759.1\|WP_006845409.1\|25181_25880_-\|D-lyxose/D-mannose-family-sugar-isomerase	unknown	unknown	gnl\|CDD\|377827
NC_015759.1\|WP_013989069.1\|27425_28724_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340877
NC_015759.1\|WP_013989068.1\|25876_26323_-\|HIT-family-protein	unknown	unknown	gnl\|CDD\|223611

Protein	Function_ID	Function_description	E-value
NC_015759.1\|WP_013989079.1\|44524_46888_-\|preprotein-translocase-subunit-SecA	gnl\|CDD\|236408	PRK09200, PRK09200, preprotein translocase subunit SecA; Reviewed.	0
NC_015759.1\|WP_013989077.1\|41677_43267_-\|accessory-Sec-system-protein-Asp1	gnl\|CDD\|274740	TIGR03713, acc_sec_asp1, accessory Sec system protein Asp1. This protein is designated Asp1 because, along with SecY2, SecA2, and other proteins it is part of the accessory secretory protein system. The system is involved in the export of serine-rich glycoproteins important for virulence in a number of Gram-positive species, including Streptococcus gordonii and Staphylococcus aureus. This protein family is assigned to transport rather than glycosylation function, but the specific molecular role is unknown. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis].	1.1443e-38
NC_015759.1\|WP_006845421.1\|38246_39323_-\|hypothetical-protein	gnl\|CDD\|236626	PRK09814, PRK09814, sugar transferase.	1.52814e-62
NC_015759.1\|WP_013989081.1\|48438_49920_-\|glycosyltransferase	gnl\|CDD\|131964	TIGR02918, lipopolysaccharide_biosynthesis_protein, accessory Sec system glycosylation protein GtfA. Members of this protein family are found only in Gram-positive bacteria of the Firmicutes lineage, including several species of Staphylococcus, Streptococcus, and Lactobacillus. Members are associated with glycosylation of serine-rich glycoproteins exported by the accessory Sec system. [Protein fate, Protein modification and repair].	8.74603e-129
NC_015759.1\|WP_006845416.1\|32337_32874_-\|phenolic-acid-decarboxylase	gnl\|CDD\|368644	pfam05870, PA_decarbox, Phenolic acid decarboxylase (PAD). This family consists of several bacterial phenolic acid decarboxylase proteins. Phenolic acids, also called substituted cinnamic acids, are important lignin-related aromatic acids and natural constituents of plant cell walls. These acids (particularly ferulic, p-coumaric, and caffeic acids) bind the complex lignin polymer to the hemicellulose and cellulose in plants. The Phenolic acid decarboxylase (PAD) gene (pad) is transcriptionally regulated by p-coumaric, ferulic, or caffeic acid; these three acids are the three substrates of PAD.	2.5948e-100
NC_015759.1\|WP_013989075.1\|39341_40106_-\|accessory-Sec-system-protein-Asp3	gnl\|CDD\|379726	pfam15432, Sec-ASP3, Accessory Sec secretory system ASP3. Sec-ASP3 is family of bacterial proteins involved in the Sec secretory system. The family forms part of the accessory SecA2/SecY2 system specifically required to export GspB, a serine-rich repeat cell-wall glycoprotein adhesin encoded upstream in the same operon.	1.93893e-52
NC_015759.1\|WP_006845411.1\|26326_27424_-\|alcohol-dehydrogenase-catalytic-domain-containing-protein	gnl\|CDD\|176188	cd05285, sorbitol_DH, Sorbitol dehydrogenase. Sorbitol and aldose reductase are NAD(+) binding proteins of the polyol pathway, which interconverts glucose and fructose. Sorbitol dehydrogenase is tetrameric and has a single catalytic zinc per subunit. Aldose reductase catalyzes the NADP(H)-dependent conversion of glucose to sorbital, and SDH uses NAD(H) in the conversion of sorbitol to fructose. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. The medium chain alcohol dehydrogenase family (MDR) have a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit.	3.82721e-53
NC_015759.1\|WP_013989080.1\|47129_48449_-\|hypothetical-protein	gnl\|CDD\|274351	TIGR02919, conserved_hypothetical_protein, accessory Sec system glycosyltransferase GtfB. Members of this protein family are found only in Gram-positive bacteria of the Firmicutes lineage, including several species of Staphylococcus, Streptococcus, and Lactobacillus. [Protein fate, Protein modification and repair].	5.5851e-75
NC_015759.1\|WP_013989070.1\|28837_29668_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	2.31029e-17
NC_015759.1\|WP_006845420.1\|37185_38250_-\|hypothetical-protein	gnl\|CDD\|236626	PRK09814, PRK09814, sugar transferase.	1.82497e-65
NC_015759.1\|WP_013989073.1\|33120_33819_-\|Crp/Fnr-family-transcriptional-regulator	gnl\|CDD\|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	1.1848e-10
NC_015759.1\|WP_013989076.1\|40098_41685_-\|accessory-Sec-system-protein-Asp2	gnl\|CDD\|379903	pfam16929, Asp2, Accessory Sec system GspB-transporter. Asp2 is a family of the SecA2/Y2 accessory Sec secretory system of Gram-positive bacteria. It is specific for large serine-rich repeat, cell-wall-anchored, glycoproteins such as GspB. Export of GspB requires the three Asp1-Asp3 proteins. Asp2, in conjunction with Asp3, probably acts as a chaperone in the early stage of GspB transport.	0
NC_015759.1\|WP_013989068.1\|25876_26323_-\|HIT-family-protein	gnl\|CDD\|223611	COG0537, Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only].	8.92424e-14
NC_015759.1\|WP_006845415.1\|31787_32336_-\|PadR-family-transcriptional-regulator	gnl\|CDD\|378427	pfam10400, Vir_act_alpha_C, Virulence activator alpha C-term. This structure is homo-dimeric, and the domain here is the C-terminal half of the structure, often associated with PadR upstream, (pfam03551), which is a transcriptional regulator.	1.06489e-10
NC_015759.1\|WP_013989071.1\|29771_31571_-\|pyruvate-oxidase	gnl\|CDD\|213733	TIGR02720, Pyruvate_oxidase, pyruvate oxidase. Members of this family are examples of pyruvate oxidase (EC 1.2.3.3), an enzyme with FAD and TPP as cofactors that catalyzes the reaction pyruvate + phosphate + O2 + H2O = acetyl phosphate + CO2 + H2O2. It should not be confused with pyruvate dehydrogenase [cytochrome] (EC 1.2.2.2) as in E. coli PoxB, although the E. coli enzyme is closely homologous and has pyruvate oxidase as an alternate name. [Energy metabolism, Aerobic].	0
NC_015759.1\|WP_081461287.1\|43269_44496_-\|preprotein-translocase-subunit-SecY	gnl\|CDD\|237095	PRK12417, secY, preprotein translocase subunit SecY; Reviewed.	2.80509e-53
NC_015759.1\|WP_006845409.1\|25181_25880_-\|D-lyxose/D-mannose-family-sugar-isomerase	gnl\|CDD\|377827	pfam07385, Lyx_isomer, D-lyxose isomerase. Members of this family of sugar isomerases belong to the cupin superfamily. The enzyme from Cohnella laevoribosii has been shown to be specific for D-lyxose, L-ribose, and D-mannose. E. coli sugar isomerase (EcSI) has been structurally and functionally characterized and shows a preference for D-lyxose and D-mannose.	2.91467e-125
NC_015759.1\|WP_013989069.1\|27425_28724_-\|MFS-transporter	gnl\|CDD\|340877	cd17319, MFS_ExuT_GudP_like, Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily. This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.8049e-79

>NC_015759.1|WP_013989073.1|33120_33819_-|Crp/Fnr-family-transcriptional-regulator
MLKYLDENSYIEYLMDKLSQNRYANLILKHNGYQLDDSDGISENIYILKSGIVKHSILNEDGNEININFQNNPGIVNLFINDRNELANSSHLVTVKSYQAWFYKINIKNFSKIVNDNYRLKKYIDIHHENELRTFINMLEYGMTYSKLGSVCAFFSQCSEQSGLEMILRDGTKVILINLELLHDDIGKFCGINNRSSVSRIIAKLKKMNILDSFHHYYIIKDLDKLNMLKLK
>NC_015759.1|WP_006845416.1|32337_32874_-|phenolic-acid-decarboxylase
MTKKFKTLDDFLGTHFIYTYDNGWEYEWYAKNDHTVDYRIHGGMVAGRWVTDQEAIIVMLTEGIYKISWTEPTGTDVALDFVPNEKKLNGTIFFPKWVEEHPEITVTYQNEHIDLMEESREKYETYPKLVVPEFANITYMGDAGQNNEDVISEAPYADMPDDIRNGKYFDENYHRLNK
>NC_015759.1|WP_006845415.1|31787_32336_-|PadR-family-transcriptional-regulator
MPRPRILPNIVLGMLSNQQLMTGKDMLQEFDYEIGEFWKSSHSQLYPELQKMVQEGTIKILPNDDGEDAKIIKYTATKLGQATLDAWLREPINEKNQHLTSLKLYFIKDSQQALLIEILEQDITIHQQKLIHLKERLTVLFGSELQVNQRYGHYLILTRAIERETNYIKWSTKVIETHAKHL
>NC_015759.1|WP_013989071.1|29771_31571_-|pyruvate-oxidase
MSKETNTINAGTAMIKVLESWGVDHLYGIPGGSINSTMDALLKEKDNIKYIQVRHEEVGAMAAAADAKLTGKIGVAFGSAGPGGTHLLNGLYDAREDHVPVLALVGQFGTSGMNMDTFQEMNENPIYADVAVYNVTVVTAESLPHIIDEAIRRDYANKGVAVVQIPVDLPWKDIPSESWYSSANSHQDFVYEHVDVQQAQSIADILSAAKRPLIYYGIGTRGAGQELEELSNKLKIPLMSTYPAKGILPDRHPHYLGSANRVAHKPANDALAQADVILFVGSNYPFAEVSNAFKNVEKFLQIDLDPSKLGKRHHTDVAMLADAKLALKKITELSSEKEETPWWQANLENIKNWNSYLDKIEHKTDGDLQAYQVYNAINSITNEKTIFSLDVGDVNQLANRHLLLKESNIHFTSNLFASMGVGIPGSIAAKLNYPDRQVFSLSGDGGAAMVMQDLVTQVQYNLPIINVVFSNNQFGFIKDEQEDTNNGYLGTTFNDIDFSKVADSMGMAGFRVDKISDLDLVFKKAQEIAKNEPVLIDVLISGDRPIPVENMKLDPAKFSDEQISSFKKRYDADELIPFSTYLKKFGVETLNDEINEGGF
>NC_015759.1|WP_013989070.1|28837_29668_+|helix-turn-helix-domain-containing-protein
MNIYWATIKKYKNKMTIPEHSHKFHQILFIKNGVYEFLINEETFIINKTTLIGIPSNFRHSYRCIEQGSILDFKININNQDDIDFNKFFIEALENSFDLMILDQLYVNMLNNLYNKNQEVILIKALDLVLTLLREKNNDVPILSVNVLTDNDMLTNVIHYFELNFLNNPKIIDIANYFNLSIHEMDKLFMTEVGVSPKKLLLNIRLEYAREKLTTDKSITYIANEIDMSLQHFSRIFKYTYGLSPKQYQKNYKNNNSQIVFNSEFDISVEPKIMIK
>NC_015759.1|WP_013989069.1|27425_28724_-|MFS-transporter
MDTLDPGVERKVKFRLLPFLFIIYFVAFLDRSSITYASLGGMDAELGLTSTFYGFIAGIFFIGYFLFGVPGNMLLEKIGARKWIGIILLLWGTVTVATGFVHSAIALVILRFLLGVFEAALFPGMTLITTYWFVSAHRAAAVAMFMVAPPLANAIGAPVAMTIIDYVHNFIGLSGWRWLFIIVGLPAVILGLITFKYLDDNPTKAKWLTSEERINLVNALDADKLKTSSNHGVVESSFKSAFKNRKVWIVTLMNVFYVVGLYGITFFLPKIISSLITSASDIQVGMLTAIPYLLGAVSLVVTAKLSDKLQKRKIFLISATLLAGVSLIAVSVFQSIPIVAFLFIILGTIGVYAWSGPYWAISTQLDPRIAAVGLGIINALGNLGGFVGPYVVGSLKDITGTQMAGVVFLAVSLILAGLITMFLKEQDTNGGL
>NC_015759.1|WP_006845411.1|26326_27424_-|alcohol-dehydrogenase-catalytic-domain-containing-protein
MVRKMVVPDMKWVDEKSENTQQVAVMENIGKIDIKYAEIPHADDYQVRVDVKWVGICGSDLEVYRGVRSPEFLTYPTRLGHEVAGIIDEVGEHVVGLKVGDKVALRYVWGAFAEYVTVDPFSAVKLPDEFDLMHGSLVEITPTILTGMERGEISQSKNVLITGQGVSGLQLTQFAKLYSPKNLVVTDLFDEKLEIAKEFGATHTYKIPTKDTPTMDIVGKDFPDGFDVVIPALLEGDAVIDALDATAQNGRIVMYGGIGKTTKPMDFFKMHRRRVDIYTTEPKRDVDNHRLFREGRDMVVNGLINTERTVTNIFPLSQIDKAFALRNQTRGDVIHIMIDSDSSHDDGRYDEANKHALETMSQYED
>NC_015759.1|WP_013989068.1|25876_26323_-|HIT-family-protein
MSNIHFEENCFYCEHNEIQKDKMSEVRKLDISTLYLNHDQTHRGRAIVALNGHVNEIFELTETERKRFFDDVSIVASILKNTFLADKVNYGIYGDMVSHLHVHLVPKYKDDIDFGDAFINNPKDLIPINEMQRAKLIENFNDALEKIK
>NC_015759.1|WP_006845409.1|25181_25880_-|D-lyxose/D-mannose-family-sugar-isomerase
MKRSDISTVITNAKKFADELRLPLPPFADWDKLTMEKLHESGVIDEIIDNKLGWDVTDFDLGNFEEYGLTALTIRNGNYNNQDKYPKPYAEKMLLVEDNQILPLHFHWYKTEDIINRGGGVLKMTMYNSTSSEDIDRTSDVEVVMDGVKKTFKAGTTIEINPGQSITLTPRIYHMWQAKKGLGKIMLFEVSSTNDDSTDNRFYENIPRMSQVEEDIDSDVLLVSDYENYLNK
>NC_015759.1|WP_006845408.1|23765_24014_-|hypothetical-protein
MAVKARIQGNAVTITLPKKLNVEAGQKFDVDMDEKGIIRLTPEKKSQISMEELFSDWDVSNEYPGENLWGNDADSKVGQEIW
>NC_015759.1|WP_006845420.1|37185_38250_-|hypothetical-protein
MTNWITRFNVSNHSQKHDAIQIVSKNVSHSAQELGFQEINFGNYYQLDDRNRRKNIIDTVLGPVQPGDLIVIQFPLWTYLNFQSEFIDQAKSIDRVRVVALVHDIPTWMFDDGTAQYDRENDFWLKQLRKFDLLLVANEKGAKRLREDGVMVPMIAMHIWDYYYDGPLKDKKFKKQLFYVGGRDVNGIDYHASTPLMIYNRHVEEKVLWNPSVDWLGRLPSDDIVASVDGGFGLVVSDNIKEKSNMNFVDYTQYNNPTKLSLYLAAGLPVIISSKTAHAKWIEERGIGLVVDNLNEIDNVLSSVTDVDYQLMLKKIEPWQKAVSEGFFIKRTLIAMLRYMELGFEDILIDNNNY
>NC_015759.1|WP_006845421.1|38246_39323_-|hypothetical-protein
MTYWITQVDDNEYVSNRASGIIANQMAADSISQIGFRRLHYPRMYASELQEMGEAARKDRLEALLSLVLPGDVVIVQYPMWTNYTQFELEYIDYLKNTRKAKIVALVWDIVSWIHDNRKRDYTVDASLWMLNRYDLVISANEKMAKRLATEGGVKTPMIAMYLSDFVYQGPLQEKKRIDQIYYVATGIDSAMIEEYQSEIPIKFIGPNWNKEKLPNYIQLLGAMNSNDIPSQLEGGFGLLYYPKTGGLKGMNHYGEYNNPMKLSLYLASGLPVITMPNTAHAQWVKDQGLGFVVDSISDIDDLIHNLSDDDYQKMVENIKPWQRAVTSGFFAKEAAIEAIRYLELGFTDRQVDVEVKK
>NC_015759.1|WP_013989075.1|39341_40106_-|accessory-Sec-system-protein-Asp3
MNNIYFTRWPDNLSDVAVTGTDIRYLEDGKVYFSNETFSPGKVLCTWRSKTNYIEQGIKPTLPLLESGQKYKLTAQLESDNGLSVQLQIIFYDINQEKIDGIILKGLSDKFTYPDDAVSYEISLLNLNNKWLKFDYLEINNVKDQRIVTAHLGKHGSFIFTTPAINGAVGKRLGITFSRGPSTITEVPELIDKSVLGGIIHVYTDGNNLKELLNEIKNKFEFKNLSVLEHQKNCFYHLTDSEIKQIKYFLSKNN
>NC_015759.1|WP_013989076.1|40098_41685_-|accessory-Sec-system-protein-Asp2
MAKAKLLIQIGGEKIKGVSNLDQQFEFHYVDVSLHKLEECFEKLSAIPLKSPNNSGNVFLFGSNEIEKLSLEILRYLPSYQIFYEDIGNTSVKNRKVLALKGAMQVNLLDQGYNFVEYLNVNYAVKPWGTSIDNSMVELSKNFSGEIQKKGSGKFIFDGDFGDDFSEIILWKNKWGPTGRTQLHAEIKVHGENIKYFYRAYYEKDGEIILWDFDGENLNLGEVYRNIGFPNFPLNIALFAKGRGKLEIGDIHLRYYLSSDNFLAIGGKRLVDPDRGNEELGYYFNVGDLKPPLNIYFSGFRPSEGYEGRWMMGSLGSPFMLVYDPRIVGGAFYRGENLEKQLVEIIKEKLDYLGFTNNQLNLSGLSMGTYASFYYGAMLEPHGILVGKPLAGIGNLALNSRLYSPYEWDLAMDTIIHTQGELNKDSALEMDKDFWNLFLSADFSKTTFAIAYMLQDTDRPFNKIFKHLKENYPTAKVLHKGLEGRHNDDTNGINTWFFKQYQDLLAADFKRNFHKNELETEIKEVSDE
>NC_015759.1|WP_013989077.1|41677_43267_-|accessory-Sec-system-protein-Asp1
MMYFIADLPEDVKSFEKIPLLNMIKNIRNNGLEYKVLLPTLVPFLRYLNSEYKLFDIEQSELIFHHIQNIQLNSGTPLTMNDLDLPNDVEKIYTRNDVLLYKNNEKFGNVKFNRFGFIDQVKYFWKNGSRIDIYSDYGFIISSKLYDESGNLERRIFYDEQENSIFEIKDEQVNIVDTISENFNKRTYSNIEEIINEFLRKALKDFNLKTDYLVIDISNDYLITLSKNFPFPEKIIFVFYGNFTTRILNKIKQISELTQAKALITDSTLLKRTLDQEHINGLNINTHLISTFSTQLSLGQSNTFRERVIYWQIDNVDKDFKKIFHKMLRYRLKFDDLRLILNVINQNDIEILKKEVVEFVNNELEINTTSDEFKMIETYFAAELEGQMSIDLKEAFETAKKNIYGFENMITAYSFIHHVEYRFKSLTKINQQDLSISRIYVNFRKTNDAFKESIVLSNGIPFISFQSSIYFKDGKNGNIIKSNNELFDVLSTYLDSNEIWNKALVESVEMINKNSSDQIMSDWGDVIDG
>NC_015759.1|WP_081461287.1|43269_44496_-|preprotein-translocase-subunit-SecY
MKKYGDLIKKSLFTILMLSIYLVGQSIPIPLHGISFQIGSEFSMQNLLSLTTGGVFSSATLFSLGMGPYMTVSILISIILFANRDRASQFSHEQRGMIQVRGIFVLSFLQSIPLAYNLQTTVTSQAIKMNYFLVFSMTIICLVAGGLLISWIASINSKYGLGGPFIMILPGIITGVTRSISANYTSVIMIASRLVILIIVTIIFVFITTGLYTTEYHVDIQRIGIDRRSKDAYYAFRILIAGTMPLMFATSFMYLPSYIMQLLDWKNDFILSFFQLTSLRGIIVYGIIIYILGIIFSFVNIMPEQIAQDLKESSDYIVGVNPGHDSQRYITRRVFVFAILGSLYLATVVITPLLIGYWTGNEIYTNFSNYFAMLFVLISILDTVRQDIDFLYYKDNYSLFNIKLKGGR
>NC_015759.1|WP_013989079.1|44524_46888_-|preprotein-translocase-subunit-SecA
MFKLKKYEKIVQKVYQVLPKYKRMVDIELQSQTNVFRSLLANGQNLEKILPDIFAVIMEADRRVLGLEPFKVQVLGGLALFFGNIAEMKTGEGKTLVATLPLYARALQGNKGNFLITSNEYLAERDGESMGKVFKWLGLTVGIGVNVDDDKKIELYDSDIIYTTHSSLGFDYLFDNLGSDLDQQAVKRFNFAIIDEIDAVLLDGAQTSLIISGAPKVQSSLFEISNWFVNSLDEEDYELSEDRKKVWFSPLGIKKFQEYFNTPETVFSARNFDIYRHIVLALQANMLKKRDQDYVVDDGKVVLLDEVNGRKMNGVKLNGGIHQAIEAKESLKITPESKTLGMVSYQSLFKKFKSLSGMTGTAKTDEKEFIDTYHLEVIEIPTNLPLIRIDKKDQIYLTNQAKIEKSLELVKKGINEKRPILIETGSVSMSQLYSLILLQNRIPHNLLNASTAPQEKQIISEVGGVNSITLATSMAGRGTDIKLTPEAKENGGLLVIGTERMTSKRIDNQLRGRAGRQGEPGESQFLVSLEDKIVVENTSNRVRKYHDINVEKGEIGEFDLYQPIDKRIVKHAIDSAQRKVGNLEAQGRERTMAFDTILSNQREKIYRTRNEVLTDDPDFIDELINSCLNEVITNFVDNYRSIELHDVADFIFNNVESAYELADIEDQLAGNMKKKNIHLFLFNVASEALDKSLDRFKNGLQLAYFKKITVLKAIDNGWIDQLDYLQQLKSIVDGRSSAQHKPINEFALEARRSFFNMEKEMWLNMFRNLLLTEIEKNIDGSIELSFP
>NC_015759.1|WP_006845428.1|46900_47101_-|hypothetical-protein
MKKDELSNVIDTKFNDEQKRHQYGKKQKIPKLQYIRPLFFTVIMSVTLIALVSKIYEVVRFLLVSK
>NC_015759.1|WP_013989080.1|47129_48449_-|hypothetical-protein
MKINIFDYYDGKTQRLLNSLRTAGISRNNLFVHYAGDLPENAISPFSFFMEIDHQKREGLFFDQVEVPEFYDIRHVNGSNANIENMGHVVGSVNYSKKGYRLVDTVDWYLNGDPKKIIKKDFYNISGKHYATSFFSEGKPYLTEYYKDGEAVVIENLVTHKIQLIIKERKIIFNNLTEFFIFFLEKAEINPDDIFINSLNYPLFIAKIVAVKPNTTLFWQEALGEKIPGNMESELNSPKALKQIIFNNEDHLKQAESQYVSTKVNLNYLSDIGEFTRKNTFIKKAFILTNSDRLYGLEDILNTFNELDITVAAYTNMSTKLEHLGDKYNNLHLIPSLAPKKLAAEMNKADIYLDINDGMKVDNVLKKAYRQNMIILSMDQVKSSNYKSLNFYDVRSLCNDLASIMSSENTWRSSLNKMIQQNGPSSKVSDYKQFLSIKN
>NC_015759.1|WP_013989081.1|48438_49920_-|glycosyltransferase
MRIFSVNKGIGFASSGVEYAQKYRRELLEELKADDYYIYLNYISKNIVIYTDLMEFPKNKILSIYNYLSERRNNESTYRVEDFLTTILDEYEIIHKNNESIRIKLKNKNTEYKIWLLKSGMIDRIDYVENSVLIRVYHYDDSLNNFEEYQKGVLVRRVFFKNDGKQAFEQYYEKGQISMTFIDGKILYGKYEFYQELFDKLQLKTDDVILIDRGLDVVEGLLPKLANKARLMSVVHAEHYNEPLSDSHHILWNNNYQYVFDHAEYFDSIIVSTERQNQVLRGQLKHKTNVVTIPVGYVDNIINNRKYDPYRMVTASRLAREKHIDVIVKAVVKAKSILPDLSLDIYGEGGERNLIQNIIDDLDANNYVHLLGHKKMNGIYGQYGAYISASTSEGFGLSLLEAISESLPIIGVDVDYGNREFIMNDQNGVLYPRTEIEELDINLEQAILDFYSNKLEISGRSVARKKAKQYLKNNVSEQWGALLGLKREVGDEN

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Crispr_ID: NC_015759_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015759_2

468788-468993

Orphan

Consensus_repeat	Method
AATTGACTTACACCTGAAGTCAATGCTGGTACTTGTGA	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_015759_2

>merge|NC_015759|2|468788-468993|CRISPRCasFinder
AATTGATCAACTCCTGAACTCAACGTTGGAATTTGAGCTTGTAATTGGCTTAATCCACCATACAAGATATTTGATCCATCAGCTAATTGACTTACACCTGAAGTCAATGCTGGTACTTGTGAGTTCAATTGACTTGTTCCAGTTGCCAATTGTTGTGATCCGGCAGCCAATTGACTTACACCTGAAGTCAAAGCTGGTACTTGTGA

>NC_015759|2|1|468788-468993|CRISPRCasFinder
AATTGATCAACTCCTGAACTCAACGTTGGAATTTGAGC	TTGTAATTGGCTTAATCCACCATACAAGATATTTGATCCATCAGCT
AATTGACTTACACCTGAAGTCAATGCTGGTACTTGTGA	GTTCAATTGACTTGTTCCAGTTGCCAATTGTTGTGATCCGGCAGCC
AATTGACTTACACCTGAAGTCAAAGCTGGTACTTGTGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_015759.1\|WP_013989326.1\|466031_466832_-\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	unknown	unknown	gnl\|CDD\|223428
NC_015759.1\|WP_013989329.1\|472001_472955_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|214988
NC_015759.1\|WP_013989331.1\|475848_476871_-\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223566
NC_015759.1\|WP_013989328.1\|471167_471920_+\|hypothetical-protein	unknown	unknown	unknown
NC_015759.1\|WP_013989332.1\|476906_477719_-\|SseB-family-protein	unknown	unknown	gnl\|CDD\|377787
NC_015759.1\|WP_013989324.1\|464756_465398_-\|TenA-family-protein	unknown	unknown	gnl\|CDD\|381691
NC_015759.1\|WP_006845882.1\|460214_461195_-\|rod-shape-determining-protein	unknown	unknown	gnl\|CDD\|237564
NC_015759.1\|WP_013989321.1\|458708_459902_-\|rod-shape-determining-protein-RodA	unknown	unknown	gnl\|CDD\|274033
NC_015759.1\|WP_013989333.1\|479604_479931_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
NC_015759.1\|WP_013989323.1\|462927_464490_-\|bifunctional-metallophosphatase/5'-nucleotidase	unknown	unknown	gnl\|CDD\|223808
NC_015759.1\|WP_006845893.1\|475042_475762_-\|2,3-diphosphoglycerate-dependent-phosphoglycerate-mutase	unknown	unknown	gnl\|CDD\|184516
NC_015759.1\|WP_006845888.1\|466828_467608_-\|hydroxyethylthiazole-kinase	unknown	unknown	gnl\|CDD\|236477
NC_015759.1\|WP_013989322.1\|461401_462769_+\|UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D--alanine-ligase	unknown	unknown	gnl\|CDD\|223841
NC_015759.1\|WP_006845897.1\|478607_479432_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|235628
NC_015759.1\|WP_013989320.1\|457911_458709_-\|NAD(P)-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|237008
NC_015759.1\|WP_013989330.1\|472935_474828_-\|beta-galactosidase	unknown	unknown	gnl\|CDD\|236548
NC_015759.1\|WP_006845899.1\|479966_480470_-\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|224336
NC_015759.1\|WP_013989325.1\|465387_466035_-\|thiamine-phosphate-synthase	unknown	unknown	gnl\|CDD\|234590
NC_015759.1\|WP_006845881.1\|459968_460181_-\|DUF2969-domain-containing-protein	unknown	unknown	gnl\|CDD\|371411
NC_015759.1\|WP_006845896.1\|477986_478520_+\|TetR/AcrR-family-transcriptional-regulator-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|274100

Protein	Function_ID	Function_description	E-value
NC_015759.1\|WP_013989326.1\|466031_466832_-\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	gnl\|CDD\|223428	COG0351, ThiD, Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [Coenzyme metabolism].	2.13971e-108
NC_015759.1\|WP_013989329.1\|472001_472955_-\|hypothetical-protein	gnl\|CDD\|214988	smart01038, Bgal_small_N, Beta galactosidase small chain. This domain comprises the small chain of dimeric beta-galactosidases EC:3.2.1.23. This domain is also found in single chain beta-galactosidase.	4.33223e-82
NC_015759.1\|WP_013989331.1\|475848_476871_-\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|223566	COG0492, TrxB, Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones].	9.68722e-66
NC_015759.1\|WP_006845896.1\|477986_478520_+\|TetR/AcrR-family-transcriptional-regulator-C-terminal-domain-containing-protein	gnl\|CDD\|274100	TIGR02366, conserved_hypothetical_protein, probable dihydroxyacetone kinase regulator. The seed alignment for this family was built from a set of closely related uncharacterized proteins associated with operons for the type of bacterial dihydroxyacetone kinase that transfers PEP-derived phosphate from a phosphoprotein, as in phosphotransferase system transport, rather than from ATP. Members have a TetR transcriptional regulator domain (pfam00440) at the N-terminus and sequence homology throughout.	1.83322e-15
NC_015759.1\|WP_013989332.1\|476906_477719_-\|SseB-family-protein	gnl\|CDD\|377787	pfam07179, SseB, SseB protein N-terminal domain. This family consists of several SseB proteins which appear to be found exclusively in Enterobacteria. SseB is known to enhance serine-sensitivity in Escherichia coli and is part of the Salmonella pathogenicity island 2 (SPI-2) translocon. This entry contains the presumed N-terminal domain of SseB.	1.98077e-16
NC_015759.1\|WP_013989324.1\|464756_465398_-\|TenA-family-protein	gnl\|CDD\|381691	cd16099, TenA_PqqC-like, TenA-like proteins including TenA_C and TenA_E proteins, as well as pyrroloquinoline quinone (PQQ) synthesis protein C. TenA proteins participate in thiamin metabolism and can be classified into two classes: TenA_C which has an active site Cys, and TenA_E which does not; TenA_E proteins often have a pair of structurally conserved Glu residues in the active site. TenA_C proteins (EC 3.5.99.2) catalyze the hydrolysis of the thiamin breakdown product amino-HMP (4-amino-5-amino-methyl-2-methylpyrimidine) to 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP) in a thiamin salvage pathway; the role of TenA_E proteins is less clear. Arabidopsis thaliana TenA_E hydrolyzes amino-HMP to AMP, and the N-formyl derivative of amino-HMP to amino-HMP, but does not hydrolyze thiamin. Bacillus subtilis TenA_C can hydrolyze amino-HMP to AMP and can catalyze the hydrolysis of thiamin. Saccharomyces cerevisiae THI20 includes a C-terminal tetrameric TenA-like domain fused to an N-terminal ThiD domain, and participates in thiamin biosynthesis, degradation and salvage; the TenA-like domain catalyzes the production of HMP from thiamin degradation products (salvage). Bacillus halodurans TenA_C participates in a salvage pathway where the thiamine degradation product 2-methyl-4-formylamino-5-aminomethylpyrimidine (formylamino-HMP) is hydrolyzed first to amino-HMP by the YlmB protein, and the amino-HMP is then hydrolyzed by TenA to produce HMP. Helicobacter pylori TenA_C is also thought to catalyze a salvage reaction but the pyrimidine substrate has not yet been identified. It has also been suggested that TenA proteins act as transcriptional regulators based on changes in gene-expression patterns when TenA is overexpressed in Bacillus subtilis, however this effect may be indirect; Pyrococcus furiosus TenA_E lacks appropriate surface charges for DNA interactions. This family also includes bacterial coenzyme pyrroloquinoline quinone (PQQ) synthesis protein C (PQQC), an oxidase involved in the final step of PQQ biosynthesis, and CADD, a Chlamydia protein that interacts with death receptors.	2.94339e-45
NC_015759.1\|WP_006845882.1\|460214_461195_-\|rod-shape-determining-protein	gnl\|CDD\|237564	PRK13930, PRK13930, rod shape-determining protein MreB; Provisional.	0
NC_015759.1\|WP_013989321.1\|458708_459902_-\|rod-shape-determining-protein-RodA	gnl\|CDD\|274033	TIGR02210, Rod_shape-determining_protein_RodA, rod shape-determining protein RodA. This protein is a member of the FtsW/RodA/SpoVE family (pfam01098). It is found only in species with rod (or spiral) shapes. In many species, mutation of rodA has been shown to correlate with loss of the normal rod shape. Note that RodA homologs are found, scoring below the cutoffs for this model, in a number of both rod-shaped and coccoid bacteria, including four proteins in Bacillus anthracis, for example. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Cell division].	6.30207e-91
NC_015759.1\|WP_013989333.1\|479604_479931_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	1.44689e-23
NC_015759.1\|WP_013989323.1\|462927_464490_-\|bifunctional-metallophosphatase/5'-nucleotidase	gnl\|CDD\|223808	COG0737, UshA, 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism].	1.01968e-85
NC_015759.1\|WP_006845893.1\|475042_475762_-\|2,3-diphosphoglycerate-dependent-phosphoglycerate-mutase	gnl\|CDD\|184516	PRK14115, gpmA, 2,3-diphosphoglycerate-dependent phosphoglycerate mutase.	2.06269e-136
NC_015759.1\|WP_006845888.1\|466828_467608_-\|hydroxyethylthiazole-kinase	gnl\|CDD\|236477	PRK09355, PRK09355, hydroxyethylthiazole kinase; Validated.	2.23056e-100
NC_015759.1\|WP_013989322.1\|461401_462769_+\|UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D--alanine-ligase	gnl\|CDD\|223841	COG0770, MurF, UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane].	5.17476e-143
NC_015759.1\|WP_006845897.1\|478607_479432_+\|alpha/beta-hydrolase	gnl\|CDD\|235628	PRK05855, PRK05855, SDR family oxidoreductase.	2.65081e-26
NC_015759.1\|WP_013989320.1\|457911_458709_-\|NAD(P)-binding-domain-containing-protein	gnl\|CDD\|237008	PRK11880, PRK11880, pyrroline-5-carboxylate reductase; Reviewed.	8.84483e-61
NC_015759.1\|WP_013989330.1\|472935_474828_-\|beta-galactosidase	gnl\|CDD\|236548	PRK09525, lacZ, beta-galactosidase.	5.25352e-151
NC_015759.1\|WP_006845899.1\|479966_480470_-\|HD-domain-containing-protein	gnl\|CDD\|224336	COG1418, COG1418, Predicted HD superfamily hydrolase [General function prediction only].	4.81892e-09
NC_015759.1\|WP_013989325.1\|465387_466035_-\|thiamine-phosphate-synthase	gnl\|CDD\|234590	PRK00043, thiE, thiamine phosphate synthase.	6.73591e-62
NC_015759.1\|WP_006845881.1\|459968_460181_-\|DUF2969-domain-containing-protein	gnl\|CDD\|371411	pfam11184, DUF2969, Protein of unknown function (DUF2969). This family of proteins with unknown function appears to be restricted to Lactobacillales.	1.83634e-17

>NC_015759.1|WP_006845888.1|466828_467608_-|hydroxyethylthiazole-kinase
MLLEVIRKKHPLILNHANTVTQQHVADGISMLGASPLMSQEQLEIPEMVKISQAVVINIGTLQETTLPELILMGQIANQAEIPVILDPVAVAMPYRSDFVKRLMKEVKFDVIRGNAAEIAWFAGMSSQGQGIDADTRIEVQTSIPKRSAQLTEAVIVQTGATDVITDGKRSWRVKNDNPLLAVNVGSGDLLSGIIGSFAAVTKDYLQAGLEATMLMGAAGQLASAKVHNQPGQLMPALMDQLYAITEKQIEQISEVNEE
>NC_015759.1|WP_013989326.1|466031_466832_-|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase
MIEVPQVLTIAGIDSSGGAGINADLKTFHNQKVYAATVITGITAQNTLGVQAIEPTRPEMIMAQFESIFTDLKITAAKTGALFDEVWVQTVIDGLKKFPVKHLVLDPVMVAKGGAQLLEPAAIELFKNELLPLAEVITPNLGEAEVLLQRSIEGDLEMIEAAQELQRLGAENVLIKGGHRQGMVVRDLMLFKNGQTSWYEAPRIDTSRTHGTGDTLAALIVAGLARNEELAAIMPAAKEFMNQAIQTTINVGHGHGPLNHWVTGVK
>NC_015759.1|WP_013989325.1|465387_466035_-|thiamine-phosphate-synthase
MKIEQLQCYLVAGPQDYPELSLTEFIVQIEVLMQSGITAYQFRDKGTHYQNCEERLDLVLKLQFLAKKWQVLFIINDDVDLAQQIHADGLHVGQGDQIQAALKVPQALPMVIGLSVSNASELAAAQDSGADYLGIGPIFATQSKTDAAPALGLAKLAEILPQNHLPIVGIGGITESVLSDLAELGLNGVAVISMLTRSDNPIETVQKIKEAWHGI
>NC_015759.1|WP_013989324.1|464756_465398_-|TenA-family-protein
MEFNQYLLAQSKDERKIIAKTQFVQALVNGSLPQEARNYYVAQDHFYVDKFDEFFQAVFQKLPIQLQIKKPQANGLEAEAHEALKPSPDLSNIAVGEHNVAYLQHIEHAVKTSDPIAGILALLPCTESYHLLARDFTDQADPKFKAWFDYYTSSDYLAFTNWLWQSLNILVPEYQQISSAQLAEWEAIYHLAYQDEIKFWQAVPMDLDQVEFN
>NC_015759.1|WP_013989323.1|462927_464490_-|bifunctional-metallophosphatase/5'-nucleotidase
MQVKVLSTSDVHGYFNADDFRRPLNNTEMGLARAVSVMQIETDKLTDEDLVLKIENGDFIQGSPLTNYIEKIDQKDLPLYDDLAALAGYDVRIIGNHEFNYGRIYLEKALQSQNVLNANILDQKSQTPFLGRPYRIFQKNDLKVGVIGLTTKFIPKWEPEKNIKGLYFADPVMIAKKYIKILRPQVDLLILAYHGGFECDLKTGQPLGRINGENQGYELSQLEGVDALITGHQHRLLAEKFNGLVMTQPGYRGEAVGVMDFTFDEKQKLINSEVKLISTKTTPENFEIITRLSPLKVKVDQWMDQLIGQVGHQMEIIDHQLARIQSHPFVELINRAQMDAGQTQIASTTIFNDEVRGLKNNVTRRDIMTNYVYPNTVVVESLTGQEIIDAIEVSARYFKLTANDNLSINPHFLFPKVQHYNYDLWTGIDYTIDMQKPMNQRVKTVMFQGKQLKLNQSYEVAVNSYRSNGTGNFKMYQASKIVREVQIETADLIADYIQKHQPLNFDQPHNLKIIGYQQIS
>NC_015759.1|WP_013989322.1|461401_462769_+|UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D--alanine-ligase
MKYSLATIAQLVDGELLNSTSEPITEITFDGRTAKPGSLFIPITWGNDGHNFIQGAIDNGASATLWAADHGENQPSDFPIIIVQDTLKAFQQLAQAYLKEIEPKVIAVSGSNGKTTTKDFIATIASTMYRTVKTPKNFNNELGVPLTILSMPADTEVLVIELGMDHPHDLDSLSKLVTPDIAVLTMIGEAHIEFFKTRARIADGKMEIINGLKPNGILVYNGDEPLLIERAANLNFQTKTFGLSTDNQLFASQITLTDQKANFTTNQMKEAFQIPLTGNYNVSNALAAISVGQLLKVPAILMKTALQGTIITENRTEWIAGNFGGQILNDVYNSNPTAVREVLKSFSAIKKLNRKFVVLGDMLELGTAGPELHASLATDVIDAKPDAIFLVGQLMQNLADKITNQDPQLTVHSFLEPEIDTLIKTLQAQLQTNDQILIKASHGLHLERIVQALTK
>NC_015759.1|WP_006845882.1|460214_461195_-|rod-shape-determining-protein
MAKEIGIDLGTANVLIFVEGEGIVLNEPSVVAVDMKTDRVLAVGTEAYQMVGRTPGNIRAVRPLKDGVISDFDMTEAMLSYFIKKLNVKGVMSRPNIMVAAPTNITEIEKKAIMQAAEKVGGAKVYLEYEPKVAAIGAGLDIFSPISSMVIDMGGGTSDIAVLSLGDIVSARSIRVAGDKLNNEITSFAKRQHGLQVGERTAEQIKIQLGNALQSEDPETMIIRGRDIYDGMPKSVEINSNEVEVALHDSFQQIVKAAHDVLAEIQPELAADVIDRGIVLTGGGALLRNMDKLISAELGVPVFIADHPLDNVARGAGELLEHMHDN
>NC_015759.1|WP_006845881.1|459968_460181_-|DUF2969-domain-containing-protein
MSNRKNKAIDVEIKAVTDQLSEVKINKNTLGQIDESGTQIQVQLGPNHKQIVNSFDEGVEVLIAEYNLHH
>NC_015759.1|WP_013989321.1|458708_459902_-|rod-shape-determining-protein-RodA
MFKRILDGKGEVDWSIIFVVLMLALIGLGSIYVAVTHDSSGANPVRIITMQGIWYILGICAVIFIMQFDSERLWRISPYIFAVGVFLMVAVLIFYSRAYAMTTGGKSWFALGPLTFQPSEVMKPAFVLMLARVIAMHNIEYSEHTLKNDLLLLRRIITWSLPIVILVLLQHDFGTMLVFLAIIFGMTLVSGISWRILGSVIGVAGVLGGGAITLVASDAGRQILGKFGFQAYQFARIDAWLKPQGDTSNSAYQLWHSMTAIGSGGLTGTGFNVSHVNVPVRESDMIFSVIGENAGFVGSLIVLLLYFLLIYRIFQVVMETSNQFYAYIGAGIIMMLVFHIFENIGMSIGLVPLTGIPLPFISQGGSALVGNMIGIGLIMSMSFHNQKYTLSEREGFA
>NC_015759.1|WP_013989320.1|457911_458709_-|NAD(P)-binding-domain-containing-protein
MFKIGFIGAGNMAQAMMQGWSKLDSGQVSQGAYTRHHLPETTQAWQVEEFDSAIEIAMVSDMLVLATPPTALEKISADLKPLLEMMPQKIVVSVLGGISLDALQAALGKQAKIVRALPNVNVAVGQGYTAMHAGTQITAEEKGAVFAILAELGRVDEMPEADFGAVSAVAGSGPAFVAGFIESLAAAGQAAGLDEERAVKLSLQTFRGTLDKMVQSDLSAPELAQLVMTPGGSTAAGWETMQKGNLNGLVSDVIQATMQKNAEFE
>NC_015759.1|WP_013989328.1|471167_471920_+|hypothetical-protein
MTDEQFQQLKRYKELLDVGVLAPNEYKRLKDRFLQVEMIALDVEQSQKPQPITETRNKSQARQKRSWKWLKPILYVLLLLIILSGGYAYLQWHHQNSQKIIQKNEQNAIVQSDLSSTKQQTKQSSSSSEKNTRTNSESSEKAANSTNLTSTVDASSVPVDDTDTASTSTAVDASSAESALTQNDSTGVAWTYQNATANGFVFVGPTNEDGSYAKALVTDRSDGQNVEIRTGTVDTDSSWSVNDDVTVPWQ
>NC_015759.1|WP_013989329.1|472001_472955_-|hypothetical-protein
MENTQNKLNLIFGDVGLGVHGPDHEYLFSYDKKGLESIRIAGREWLLEPVKPIFWRATTDNDRGAGFPQKVASWLGADLFQTGSVKTIWVDQQILELPLPPVNNKYNGDESAQEVAILYEYQLPVQPQTKVEILYQVNAIGQLKVKAHYFGQKGLPELPVFGVRFMIPTLTNRFIYTGLSGETYPDRKQGGQFGTYHVQGIPVTPYLIPQDNGVHMETQTVTLERTSTKNNVEPVVHPFELTVRKTKQPFAFSCLPYTAAELENATHQEELPLPRKTVLSILGSVRGVGGIDSWGAEVLPDYRISGEIDHEFEFMLE
>NC_015759.1|WP_013989330.1|472935_474828_-|beta-galactosidase
MLPQLAWLDDPKIFRVNQLPAHSDHQVYRNLIEAHQKQSSLEKSLNGTWDFYYTDQMETFNSELEVPDFEKNTAVTTIEVPKHIELANFAPIQYVNTQYPWDARTYRRPPFTNQDEQIPGVFSRADDNAVGTYRKIFKLDPDWQDQKVHINFAGVERAFYLWLNGQFVGYAEDSFSPSEFDLTPYLKNNGENELIVQVFKHSTASFIEDQDFFRFFGIFRDVTLLLQPGVHVTDIALKPQVSADYQMGKLTGEFKLTGEFSQYELEIKIINPQGEIIFQGQPNLNHEIRLPEIKFYDMQLWSHKNPQLYHIELIVKNQEHQLIEVATTTFGFRKIELDHQVLKLNGERLKILGVNRHEWNPENGRVITRDDMLTDLKIFQEHHINAVRTSHYADQLSWYQLCDEHGIYMMAETNLESHGSWQKMGQLEPSYNVPGSLPGWKDAVLDRAKTNYETFKNHPSVLFWSLGNESYAGTNLSEMQEYFHKVDSTRLVHYEGVVWDRQFEDQISDFESRMYASPAEVRKYLEQNPKKPFMLCEYMHDMGNSLGGLAEYMQLFDDFDNYAGGFIWDYIDQALWVNDEISGQKVLRYGGDFDDRPSDYGFSADGLLFANRLVKPAMQEVAYQYGKYTE
>NC_015759.1|WP_006845893.1|475042_475762_-|2,3-diphosphoglycerate-dependent-phosphoglycerate-mutase
MAKLVLIRHGQSEWNALNLFNGWVDTKLSDKGIAQAKAAGEMLAKEGIEFDQAYTSVLTRAITTLHYALEEAGQMFIPETKSWRLNERHYGALQGLNKADAAAKYGDEQVHQWRRSYDVLPPLLTEQAKTVEVLGKTYPAFDRRYADVPEGQLPFGENLKVTLERVLPFWESNISKDLAAGKNVVIAAHGNSLRALVKHIENISDDDILGVEIANGQPLVYDFDQDLKVLSKNVLTSEN
>NC_015759.1|WP_013989331.1|475848_476871_-|NAD(P)/FAD-dependent-oxidoreductase
MVTTKKVDLVIIGAGPVGLFAAFYARLRELNVVLIESLSIPGGQPQNLYPQKQILDVPGWLGLNGVELTGNLVEQLQQLQPEIYLDTTVIDVKNTDEAVLVETDRAINFEADAILVATGKGAFEPRRLDNELEQDFENHGLYYFVPDLQQFKDKRVTILGGGDSAVDLANQLVTVAKDVQLVHRRNNFRALEHTLLTLEQSNVKKLTPYVVQAINKNSDQTFNLELKATRGEEIEHLTTDAIIVSYGFKSENKIVEGWSIKPAMSRQKIAVDQNMRTSVPRVFAIGDAAEFEHKAELIVTGFGDAPVAINTIIDQYIQNHQGVLHSSSVKIKDGQVQSEK
>NC_015759.1|WP_013989332.1|476906_477719_-|SseB-family-protein
MTVINIDNTVLKEALANFKAVQNEELQTKFELALLNANFLVPVQVPEDLVPDAEGNLNVSAGQQLAFVTLIGPDESNFLPIFTDNENYQSNPEDWSQNIMVVEFPFVQFIEMFKQDENLQNLIMNPFIPEETLQIGRDNVEYLMQNYDYQGEPQKVEGNETENETDQSIEIRVPDEIPTKLQANLMGLADDTNGAVSEMYLLWMQGAGGQQGRFLLILDGDDEQLNSQIDNFRAIFPETMGEEMMGEVVLKQEIAGLDLSEFQAFYQYQM
>NC_015759.1|WP_006845896.1|477986_478520_+|TetR/AcrR-family-transcriptional-regulator-C-terminal-domain-containing-protein
MNTREQIKIEFLKLIASSSFDKVRISTICKNVNIQRKLFYYYFEDKYALLNDIYQDDLSLNFNISETNKINWKNGAKLLLETYKSRGAFYKNSITVDNNQWHNIFLTHMRALFIRLFNELSANDDKNFYFNATFFSNGWTGIIENWIINDFDIDIAVLIDQFYALIHFTKFNISKWE
>NC_015759.1|WP_006845897.1|478607_479432_+|alpha/beta-hydrolase
MQRLEVQLSNVKLSYFDEGTGAVIFLLHGFPDSADVWRNIIPGLVSAGYRVIAPDLRGFGQSELKPNKDDYKIKFIMQDILELKASLNLTQPVKLVAHDWGANIGWMLISFFPDQFSSYFPISVGHPYAYALDGGFEQKKKGWYTMAFQFEEMAEKMFSQNDWAAFRIFTENNSELDTNWLPDLKRAGRFTAALNLYRANLVPSDNDSKLAPTPVPVHGLYGKNDLYLSQSQMEQSGKYTSGPFNFSLIDGGHWLQIEAPELVLNSILNFYKTL
>NC_015759.1|WP_013989333.1|479604_479931_-|helix-turn-helix-transcriptional-regulator
MASTEIKTAASLSPKFIATFEILGRKWNGLIVEALLIDGPKRFKDLAATIETCSDRVLVERLKELEEANIIERTPVSDSSRRAYQLTERGEAMRPMMSAIHTWADQYN
>NC_015759.1|WP_006845899.1|479966_480470_-|HD-domain-containing-protein
MQKDAWKNDRAYRDIVDDLLQQPAVQELANYTQHHHSDRLTHSIMVSYWSYRLGLRLGLNATALARAGILHDLFYYDWRDTKFELGTHAFIHPRVSLRNAEKITSLSEMEKDIILKHMWGSTWAMPHYWESLLLNLVDDETAVMDFFNPVLDSFKALKTLHWINRES

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Crispr_ID: NC_015759_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015759_3

1144622-1144718

Orphan

Consensus_repeat	Method
AAAAATTTAAATTAAATTTATTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015759_3

>merge|NC_015759|3|1144622-1144718|CRISPRCasFinder
AAAAATTTAAATTAAATTTATTTTCAAAGAGGTTGGGGGATTTTCATCTCAGCCTCTTTTTTGTATTATGAATAAAGAATTTAAATTAAATTTATTT

>NC_015759|3|2|1144622-1144718|CRISPRCasFinder
AAAAATTTAAATTAAATTTATTT	TCAAAGAGGTTGGGGGATTTTCATCTCAGCCTCTTTTTTGTATTATGAATA
AAGAATTTAAATTAAATTTATTT

Protein	Signature genes	Signature genes Name	Protein_function
NC_015759.1\|WP_006845122.1\|1142668_1142944_+\|co-chaperone-GroES	unknown	unknown	gnl\|CDD\|178988
NC_015759.1\|WP_013989722.1\|1137596_1138787_+\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|235985
NC_015759.1\|WP_013989727.1\|1144878_1145373_+\|hypothetical-protein	unknown	unknown	unknown
NC_015759.1\|WP_013989732.1\|1149332_1151282_+\|threonine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234752
NC_015759.1\|WP_013989728.1\|1145384_1145930_+\|ECF-type-riboflavin-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|184218
NC_015759.1\|WP_013989726.1\|1141905_1142544_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|224336
NC_015759.1\|WP_013989730.1\|1147999_1148494_+\|DUF1456-family-protein	unknown	unknown	gnl\|CDD\|227144
NC_015759.1\|WP_013989723.1\|1138826_1139444_+\|ECF-transporter-S-component	unknown	unknown	gnl\|CDD\|225814
NC_015759.1\|WP_013989735.1\|1153402_1153966_-\|ECF-transporter-S-component	unknown	unknown	gnl\|CDD\|227065
NC_015759.1\|WP_013989721.1\|1134623_1135805_+\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271189
NC_015759.1\|WP_013989729.1\|1145946_1147971_+\|DNA-mismatch-repair-endonuclease-MutL	unknown	unknown	gnl\|CDD\|234630
NC_015759.1\|WP_006845123.1\|1142998_1144621_+\|chaperonin-GroEL	unknown	unknown	gnl\|CDD\|234573
NC_015759.1\|WP_013989731.1\|1148530_1148986_+\|flavodoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|180922
NC_015759.1\|WP_173677192.1\|1136001_1136562_+\|DUF402-domain-containing-protein	unknown	unknown	gnl\|CDD\|184219
NC_015759.1\|WP_013989736.1\|1154283_1155258_+\|ribose-phosphate-pyrophosphokinase	unknown	unknown	gnl\|CDD\|223538
NC_015759.1\|WP_013989734.1\|1152019_1153399_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213192
NC_015759.1\|WP_013989724.1\|1139521_1139905_-\|large-conductance-mechanosensitive-channel-protein-MscL	unknown	unknown	gnl\|CDD\|376605
NC_015759.1\|WP_006845116.1\|1136742_1137486_-\|M15-family-metallopeptidase	unknown	unknown	gnl\|CDD\|350618
NC_015759.1\|WP_013989733.1\|1151342_1152017_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223692
NC_015759.1\|WP_013989725.1\|1140117_1141779_+\|formate--tetrahydrofolate-ligase	unknown	unknown	gnl\|CDD\|376511

Protein	Function_ID	Function_description	E-value
NC_015759.1\|WP_006845122.1\|1142668_1142944_+\|co-chaperone-GroES	gnl\|CDD\|178988	PRK00364, groES, co-chaperonin GroES; Reviewed.	3.4679e-34
NC_015759.1\|WP_013989728.1\|1145384_1145930_+\|ECF-type-riboflavin-transporter-substrate-binding-protein	gnl\|CDD\|184218	PRK13661, PRK13661, ECF-type riboflavin transporter substrate-binding protein.	8.63014e-44
NC_015759.1\|WP_013989733.1\|1151342_1152017_-\|ABC-transporter-permease	gnl\|CDD\|223692	COG0619, CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism].	0.000366867
NC_015759.1\|WP_013989732.1\|1149332_1151282_+\|threonine--tRNA-ligase	gnl\|CDD\|234752	PRK00413, thrS, threonyl-tRNA synthetase; Reviewed.	0
NC_015759.1\|WP_013989722.1\|1137596_1138787_+\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|235985	PRK07309, PRK07309, pyridoxal phosphate-dependent aminotransferase.	2.16477e-138
NC_015759.1\|WP_013989726.1\|1141905_1142544_+\|HD-domain-containing-protein	gnl\|CDD\|224336	COG1418, COG1418, Predicted HD superfamily hydrolase [General function prediction only].	1.28293e-20
NC_015759.1\|WP_013989730.1\|1147999_1148494_+\|DUF1456-family-protein	gnl\|CDD\|227144	COG4807, COG4807, Uncharacterized protein conserved in bacteria [Function unknown].	1.72339e-37
NC_015759.1\|WP_013989723.1\|1138826_1139444_+\|ECF-transporter-S-component	gnl\|CDD\|225814	COG3275, LytS, Putative regulator of cell autolysis [Signal transduction mechanisms].	0.000362449
NC_015759.1\|WP_013989735.1\|1153402_1153966_-\|ECF-transporter-S-component	gnl\|CDD\|227065	COG4721, COG4721, ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism].	1.9243e-43
NC_015759.1\|WP_013989721.1\|1134623_1135805_+\|site-specific-integrase	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	8.40422e-41
NC_015759.1\|WP_013989729.1\|1145946_1147971_+\|DNA-mismatch-repair-endonuclease-MutL	gnl\|CDD\|234630	PRK00095, mutL, DNA mismatch repair endonuclease MutL.	0
NC_015759.1\|WP_006845123.1\|1142998_1144621_+\|chaperonin-GroEL	gnl\|CDD\|234573	PRK00013, groEL, chaperonin GroEL; Reviewed.	0
NC_015759.1\|WP_013989731.1\|1148530_1148986_+\|flavodoxin-domain-containing-protein	gnl\|CDD\|180922	PRK07308, PRK07308, flavodoxin; Validated.	3.92396e-30
NC_015759.1\|WP_173677192.1\|1136001_1136562_+\|DUF402-domain-containing-protein	gnl\|CDD\|184219	PRK13662, PRK13662, hypothetical protein; Provisional.	2.5164e-123
NC_015759.1\|WP_013989736.1\|1154283_1155258_+\|ribose-phosphate-pyrophosphokinase	gnl\|CDD\|223538	COG0462, PrsA, Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism].	2.91775e-126
NC_015759.1\|WP_013989734.1\|1152019_1153399_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213192	cd03225, ABC_cobalt_CbiO_domain1, First domain of the ATP-binding cassette component of cobalt transport system. Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC transport system of the CbiMNQO family is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most of cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems.	3.77069e-76
NC_015759.1\|WP_013989724.1\|1139521_1139905_-\|large-conductance-mechanosensitive-channel-protein-MscL	gnl\|CDD\|376605	pfam01741, MscL, Large-conductance mechanosensitive channel, MscL.	7.50368e-50
NC_015759.1\|WP_006845116.1\|1136742_1137486_-\|M15-family-metallopeptidase	gnl\|CDD\|350618	cd14843, D-Ala-D-Ala_dipeptidase_like, D-Ala-D-Ala dipeptidase, includes uncharacterized enzymes. This subfamily of D-Ala-D-Ala dipeptidase (also known as D-alanyl-D-alanine dipeptidase vanX; VanX; EC 3.4.13.22) also includes several uncharacterized proteins. This is a Zn2+-dependent enzyme that mediates resistance to the antibiotic vancomycin in Enterococci and other bacteria (both Gram-positive and Gram-negative). It is part of a gene cluster that affects cell-wall biosynthesis. The operon triggers the termination of peptidoglycan precursors by D-Ala-(R)-lactate instead of D-Ala-D-Ala dipeptides. The enzyme is stereospecific, as L-Ala-L-Ala, D-Ala-L-Ala and L-Ala-D-Ala are not substrates. It belongs in the MEROPS peptidase family M15, subfamily D.	4.09364e-68
NC_015759.1\|WP_013989725.1\|1140117_1141779_+\|formate--tetrahydrofolate-ligase	gnl\|CDD\|376511	pfam01268, FTHFS, Formate--tetrahydrofolate ligase.	0

>NC_015759.1|WP_006845123.1|1142998_1144621_+|chaperonin-GroEL
MAKELKFSEDARAKMKAGVDQLADTVKTTIGPKGRNVVIEQSYGAPTITNDGVTIAKSIELEDHFEDMGAKLVAEVASKTNDIAGDGTTTATVLAQAIINEGLKNVTAGANPVGVRRGIELATNAAVQSLHDMSKTVSTKEEIAQIASISAANEEVGALIAEAMDKVGHDGVITIEESKGIETTLDVVEGMQFDRGYMSQYMVTDNEKMEANLDNPFIMITDKKIGNIQDILPVLQQVVEQGRSLLIVADDITGEALPTLVLNKMRGTFNVVAVKAPGFGDRRKAMLEDLAVLTGGTVITDELGLNLKDVTIENLGQAAKVTVTKDSTTVVEGAGDKQLLSERVALIKGQIEETTSDFDREKLQERLAKLAGGVAVINVGAATETELKERKYRIEDALNATRAAVEEGFVAGGGTALVNAIPAVSALTAEGDVQTGINIVERALEAPVRQIAENAGLEGSVIVNKLKEQTLGTGYNAADDTWVDMIDAGIVDPTKVTRSALQNAASVSALLLTTEAVVAEQPKDETVMPAAPQGGMNGMM
>NC_015759.1|WP_006845122.1|1142668_1142944_+|co-chaperone-GroES
MLKPLGDRVLLQVNDEKEQTVGSIVIASNAQEKSATGTVVAVSETTVGDLEAPKSVKIGDEVIYDQYAGKEIKNDGETYLVLHERDIMAIL
>NC_015759.1|WP_013989726.1|1141905_1142544_+|HD-domain-containing-protein
MKVEAIKDYVREITSQEFSGHDYLHLERVLQNAELLMQSEEGFKRDVIVTAVLLHDLIDEKLTNNINEMIDEIRIKMREWGLADDERAEVLDIITHMSFAKNLEQHHVLNLDGEIVQDADRLDALGAIGIGRAFTYGGHANNLMYNPNEAVRENMTSAEYRQHSTVINHFHEKLLKLEGEMNTATAKKLAARRTAFMRFYLDEFTAEINGDK
>NC_015759.1|WP_013989725.1|1140117_1141779_+|formate--tetrahydrofolate-ligase
MTTDIEIAQQAEIWPIQKVAEKVGLSEDDLEMYGPYKAKITLNEKQKKQELGKLILVTAISPTPAGEGKSTVTIGLADALNLTDHQTMVALREPSMGPVMGMKGGATGGGYSQVIPMADINLHFTGDFHALTIANNTLAALIDNSLQKGNPLQIDSRKIIWKRVLDVNDRALRHITIGLGGPTSGVPREDGFDITAASELMAILTLSTSLMDLKARIKRIVVAYDINNKPVTVDDLGVAGALTVMLKDAIKPNLVQSLGHTPTLIHGGPFANIAQGTNSLLATKTALRLSDYVVTEAGFGSDLGGEKFLDVKVPLLGKTPDTIVIVATVRALKYNGGQSLDTLTQPNLEMLEAGLANLGQHLKAMQRYQTPVIVAINRFTDDTEAELDLIKNFVQNHQAQAVVADVWGQGGSGAIELAQTVAAATETESAFKPLYASEDTFEEKIEKLVTEIYGGVDYELSDQAQKQLQQFKQLGWDKMPIVMAKTQYSLSDNPKALGAPKNFKIHVRELVPKLGAGFIVALTGSILTMPGLPKVPAANRIDIDENGVITGLD
>NC_015759.1|WP_013989724.1|1139521_1139905_-|large-conductance-mechanosensitive-channel-protein-MscL
MLKEFKEFISRGSVLDLAVGVIIGGAFTGLVKSLTNNLINPIIGLFTGQVSSLDNLKLTITDNLVLKYGAFLGDVINFLITAFVVFLIIKFLNKALRRDKSKDEPEVVNPEVEMLAEIRDLLADQKK
>NC_015759.1|WP_013989723.1|1138826_1139444_+|ECF-transporter-S-component
MTNKKRSTRQLVLTAMFMAIILLQCMVPWMGFIPINPMVRVTIIPFTVALGGMLLGPKVGGLLGAVMGLYSFYHAWTLPVGIGSLMLRDPITALLPRMLVGIIIGLIYLKWINNSKHKTSPFLMFMLGALAAIINTGLVITLTWIHFRIFNTTVAGLPNHVGIIWMFTSIAGVNVLIEIVVDGLLGMLVGWPVLRYMEKARLANH
>NC_015759.1|WP_013989722.1|1137596_1138787_+|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme
MSQEFVQPINQTVQAMTIDGLTGFQKKIAGIEDLVYLTFGEPGFNIEDSIKDAVIDGVKNNHSHYAVAEGDLVLRQAAVDNYNEKFDLNFQGPENVVVTSGVTEAIYALFQTLLNPGDGVLIPTPAYPPYYAAINIIGGKMLKVDTSQSEFKITPQMVDDAIASADFPVKVILFNYPSNPTGATYTETELRALAETFKKHHIWVISDEIYAELTYDIKHVSMMKLLPEQTVMITGLSKSHAMTGYRIGFVIGSAEIIAEVSKVHDTLTFALPQVTQDGAIAALTQAKDAPAKMRKVYQRRRDFVVEKMTAMGFKVGNPQGAFYIFARIPEDFSAGVDGLDFAWALATEGGVGVAPGIAFSDQTAEYIRISYAANDDDLASGMERMAAWIDQKRASR
>NC_015759.1|WP_006845116.1|1136742_1137486_-|M15-family-metallopeptidase
MGKNIQNKIPTDLSEWDWSTALDPDIKDNNEPLVPLGLLPEKIIVQPAYFIQNLSGAMSELYARQTVQSKLVQAANLLPAGYKLVIFDAWRSVSTQAALFHSLKRKIARTNPSWTKNQMIEKTLETVAQPSRDPKKPSPHNTGGSIDLTIVDDQGVMLDMASPFDDFNDSSKTNYLELKAELNQSELKARDNRRLLYHIMTEVGFTNLSNEWWHYDYGNQNWASCSQQEHALYGATKPFFPWVTILD
>NC_015759.1|WP_173677192.1|1136001_1136562_+|DUF402-domain-containing-protein
MKVMRNSRLPREGDYITIKSYKHDGSLHRTWRETMVLKTSENEIIGINDHTVVIEDDGRRWVTREPAIVYFHRKYWFNIVAMIRDNGVSYYCNLASPFVLDKEALKYIDYDLDIKVYPDGEKRLLDADEYQAHREKWNYSNEVDFILSEHVKILVDWIQQQEGPFSKGYVDLWYRRYQEIKNRAHR
>NC_015759.1|WP_013989721.1|1134623_1135805_+|site-specific-integrase
MSIRKLKNGKYQVRVYVGTDEVTGHTTYKYRNTDSKTSAIMIEKQLNEAIERGEIVIKELEHLQPQPYTFEEAYKEWWKFYESQNFAQSTKDKVARHFKNHLLKPKLFGNLRLDRIIRIDIQNKVNKFIPQYTQSKEMLGYAKRVFKYAVDSEHIICDSNPLEHIQMVRVKKAPRREVRFYNEIQAKMFEHGINEYYQRGDKFLALFTVLLRTGMRGGELCGLKWNNVDFERCELLLNGRMSLDGHGKDHYLKGLKNGDDFRYIDIDDVVIDKLKAWHYVQAQQSMLKGQPINDESFVFDVLRNQMYSQFASFLEWYNCNNTQKLPYLNIHGLRHTHASLLISSGMDLKKVSDRLGHKDIAVTANIYAELTPKARREVADVFSNIMGDVKENY
>NC_015759.1|WP_013989727.1|1144878_1145373_+|hypothetical-protein
MQLTGNEVIEALKNEEIEHKVWTAEDQTLINLDPLFLFLEQKINENKLVSGEIIISGDEPIHLSVETNVINLPLRYVNQISKIIINDPETDVNVYMFVDHPDVTRSGMRIELAASVQSFLDDRESVMSKISLFFDREIQNISKNQAEKDEQAEVEGSAKIEKKD
>NC_015759.1|WP_013989728.1|1145384_1145930_+|ECF-type-riboflavin-transporter-substrate-binding-protein
MRLKKLKWILALVVSVIFFALIMPIFNLPVGVRNTQITFGMAWLSLVTAVFGPIFGLLMGLLGHALQDYSLLGNAWWSWVIADGLFGLLLGLVTQRLQLIFSPLSWHKVITFNIWQGLANLIAWVIIAPLGDILIYGSKAKLVFKQGLYAGIANFFVIAVFGTILIIITNYLIKLFKISRK
>NC_015759.1|WP_013989729.1|1145946_1147971_+|DNA-mismatch-repair-endonuclease-MutL
MQEIIELSETLANQIAAGEVIERPASVVKELVENAIDSGAHKIDILIEAAGVQSIEVIDDGQGIPTDQLERAFLRHATSKIQTKQDLFQIHSLGFRGEALPSIASVADVFLETAVVDATSGAMIHIKGNKIIEKKGSGARRGTKIKVSDLFFNTPARLKYLKSQSTELAKIVDIINRLAFSYPAIAFNLVHNQKQLTQTVGNGNLQQVISSVYGLSVARDMVTIDDHDADFKVQGWISKPELTRSNRSYISLLINGRYVHNFNLAKALIKGYGTRLMVGRFPMAVLKIELDPSLVDVNVHPQKFEVRISKEDKLLALIEKMVAEAFDNVNLIPNATENLIESSVKKNYDGQPEKSFIQQLNTVSKNKQVQNQNQRVNLSVDGLLDSQKANGLSENQDIQSFHEERQITPIVVEHLGDLNEATVEAFEQKYQQESKANPFGLDSSTVIAGEQTQLTLDHETESTSELAGFPKLEYLSQLHGTFLFAQGSDGLYLIDQHAAQERVKYEYYQATLAKHDLEQQKMLVPLVFEFTTVEMLELESQAETLRELGLHLENFGPNTLILREHPGWFPAGQEADTVHEMVDWLLREGGLTLQQFREKTAIMMACKRSIKANWKLNAIEAQNLIDQLAQTKNPYNCPHGRPVVINFKETDLEKMFKRIQDSHENWVEYDNHPF
>NC_015759.1|WP_013989730.1|1147999_1148494_+|DUF1456-family-protein
MNNNDIVIRLRYALAISNADMLKIFKLGGLELTNEKLVKILKRQDKETPRDQNLTMEELERFMNGLIISQRGIKKDANGQTSEPTFDMKKEDDINNVVLKKLKIAMQYTSEDYQSFFKSAGIEVSNAELSAVLRRPDHRNYRPAGNRYLRNILKGMALEYRKEQ
>NC_015759.1|WP_013989731.1|1148530_1148986_+|flavodoxin-domain-containing-protein
MRARVLYATLTGNNEDVADVIIAEFERLGVQTIKEDISDVEALDLNPTTQDILVTVVYTFDLGTLADEAIDFYEDLPDVDLEGVIYGVAGSGDVYYGKDYGTAVDILEKQFSKTAGIHGASGVKVNLRPDAKATDELQKFTQALVQKASNN
>NC_015759.1|WP_013989732.1|1149332_1151282_+|threonine--tRNA-ligase
MADIEIKFPDGAVKNFASGVTPLEIANGISKSLAKKAVSGRLNGEYVGMHDQMMVGGDFELITKDSEEALRLLRHSASHLMAQALKRLHPDMNFGVGPAIDNGFYYDTDNAEGQVSVEEFPAIEKIMHKIVEENLPIVSRVISREEALDMFKDDPYKVELINDLPIDEKISIAVQGDHVELDKGGLVPSTGWIKNFKLTSVAGAYWRGKSSNPMLQRIYGTAFWNADDLQAELKRRDEAKERDHRRIGAQQDLFFTSQEVGSGLPVWMPNGAAIRRTLERYIVDRELEAGYEHVYTPILSNLDLYKTSGHWDHYHDDMFPPMDMGDGEFLELRPMNCPSHIQVYNHHPRSYKELPLRIAELGMMHRYEKSGALTGLSRVREMTLNDGHTFVTLDQIEDEFKNILNLMIDVYHDFNISDYRFRLSYRDPKNTEKYFDDDEMWANSQRMLKAAMDDLGLDYFEAEGEAAFYGPKLDVQIKTALGGEETLSTIQLDFLLPEKFDLGYVGSDGEQHRPVMIHRGVISTMERFTAYLIEMYKGAFPTWLAPHQVRVIPVNRGAHSEYAEKIVEQLKHQGIRAEYEDRNEKLGYLIRDAQSLKIPYTLVIGDDEKNNESVTIRRFGSRDTETMPLAEFEKTLLADIANYSRTDQK
>NC_015759.1|WP_013989733.1|1151342_1152017_-|ABC-transporter-permease
MAGHFKFEPALLLSTVLLASIEISFVRSIPGNLFLVLIGLFYLFLNQINYRKIGLLLLISIPLAFGTWTSFWFFGTGDHLTNARLYTSRLYAYLILGGLVTLTSTPRDLLINLHARFKLSNTFVYGILAALNLLDQVKQQIKTIQYAAKLRGIKYHLWSPQLYFKTILSANYWATDLTNAMHSHGFSEGQSRTEALPMPWPIVQIIILILILVLFNGILWFCKN
>NC_015759.1|WP_013989734.1|1152019_1153399_-|ATP-binding-cassette-domain-containing-protein
MTLLKINDLTFTYPNDAKPVLNQVNWSLDPHSFNLLSGPSGVGKSTLLRLMAGLERPQSGTITIDQYPIHTVVPFERAKHVALLFQNPSRQFTMQTAQEELQFALENLQTPQAQIEPRIEKVLTALNLTDIADRPLLHLSGGEQQKAALAIILAMDTNIIVLDEPFANVDPDARLSLLKTLKQIQLEQDKTIIITDHDLNNYQQIIDHHYQLTSAGELIISKSNQLMTAPPVIFKKRTNLINGSLSWTDLSITQAKKTLLKPNSFTLPAASIGLLSGQNGSGKSTLLQTISRQRPLNGTLTWDGQSHLKDWSSFVGYGFQTASNQFITMTPAEEFSISLKISQQAEYWTPTLINSCIEQLQLTEVLNHSVYQLSGGQQKKVQTLALLILGLPVLLLDEPLAGLDLQSIKIVMNIMQKYIKSTQTSILMISHQRHGLETFIDYERNLTQQTLINPAERGL
>NC_015759.1|WP_013989735.1|1153402_1153966_-|ECF-transporter-S-component
MQTIPDNSSHWQLKDVIFLALIALFFGVIYQIWGFSYTFIAATPLKPFANDATLGVWLMAGPLAGRLIPKPGSATLGEFLAATIEMFLFSQWGAMNLVSGLIQGLGAEIGFASTKYRPRPKTNLFISALMMTILTFIWDLFQSGYLAYHLPMLALLFIIRFISTGFFAGILVNLIEKMVTKTGAIRK
>NC_015759.1|WP_013989736.1|1154283_1155258_+|ribose-phosphate-pyrophosphokinase
MEHELKLIGLSTNHELAQKIADEMGADLMPMTINQFADGEIYERILESVRGADVYILAPISGEVNDSFMEIMIVVDALRRASAHGINVVMPYFGYVRQDRKTKSREPITAKMVSSLLEMNGVQRILAIDLHADQVQGFFDIPVDQLLAAPLLSDYFLERNFTGEDTVVFAPDHNGAGRARQFASILEANWGVINDRAVQEDIKSPNGIVGEVAGKRVIVIDDIIDTGRRMVTSAKAVKYAGAIDVSVVATHGVLSDGAAERLKNCDEISQVVITDTVEVPAEKQFDKLKIITVAPLIADAINRVRQDKDLSGLLRSRIKPDIKI

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Identity
NC_015759_1	1.1\|35903\|15\|NC_015759\|PILER-CR	35903-35917	15	NC_015759.1	35817-35831	1.0
NC_015759_1	1.1\|35903\|15\|NC_015759\|PILER-CR	35903-35917	15	NC_015759.1	36051-36065	1.0
NC_015759_1	1.2\|35981\|27\|NC_015759\|PILER-CR	35981-36007	27	NC_015759.1	35805-35831	1.0
NC_015759_1	1.2\|35981\|27\|NC_015759\|PILER-CR	35981-36007	27	NC_015759.1	36039-36065	1.0

1. spacer 1.1|35903|15|NC_015759|PILER-CR matches to position: 35817-35831, mismatch: 0, identity: 1.0

ctgaaatattatctg	CRISPR spacer
ctgaaatattatctg	Protospacer
***************

2. spacer 1.1|35903|15|NC_015759|PILER-CR matches to position: 36051-36065, mismatch: 0, identity: 1.0

ctgaaatattatctg	CRISPR spacer
ctgaaatattatctg	Protospacer
***************

3. spacer 1.2|35981|27|NC_015759|PILER-CR matches to position: 35805-35831, mismatch: 0, identity: 1.0

ttgattcgctatctgaaatattatctg	CRISPR spacer
ttgattcgctatctgaaatattatctg	Protospacer
***************************

4. spacer 1.2|35981|27|NC_015759|PILER-CR matches to position: 36039-36065, mismatch: 0, identity: 1.0

ttgattcgctatctgaaatattatctg	CRISPR spacer
ttgattcgctatctgaaatattatctg	Protospacer
***************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_015759_1	1.2\|35981\|27\|NC_015759\|PILER-CR	35981-36007	27	CP024685	Bacillus wiedmannii bv. thuringiensis strain FCC41 plasmid pFCC41-1-490K, complete sequence	489608-489634	6	0.778
NC_015759_1	1.2\|35981\|27\|NC_015759\|PILER-CR	35981-36007	27	MK448581	Streptococcus satellite phage Javan620, complete genome	10075-10101	6	0.778
NC_015759_1	1.2\|35981\|27\|NC_015759\|PILER-CR	35981-36007	27	NZ_LR215005	Mycoplasma conjunctivae strain NCTC10147 plasmid 9	49098-49124	6	0.778
NC_015759_1	1.2\|35981\|27\|NC_015759\|PILER-CR	35981-36007	27	MN693374	Marine virus AFVG_25M38, complete genome	8945-8971	6	0.778

1. spacer 1.2|35981|27|NC_015759|PILER-CR matches to CP024685 (Bacillus wiedmannii bv. thuringiensis strain FCC41 plasmid pFCC41-1-490K, complete sequence) position: , mismatch: 6, identity: 0.778

ttgattcgctatctgaaatattatctg	CRISPR spacer
atgattcactatgtgaaatattattat	Protospacer
 ******.**** ***********.

2. spacer 1.2|35981|27|NC_015759|PILER-CR matches to MK448581 (Streptococcus satellite phage Javan620, complete genome) position: , mismatch: 6, identity: 0.778

ttgattcgctatctgaaatattatctg	CRISPR spacer
ttaattcactatctgaaatattagagc	Protospacer
**.****.***************

3. spacer 1.2|35981|27|NC_015759|PILER-CR matches to NZ_LR215005 (Mycoplasma conjunctivae strain NCTC10147 plasmid 9) position: , mismatch: 6, identity: 0.778

ttgattcgctatctgaaatattatctg	CRISPR spacer
ctaattcgctatctgaaataatattaa	Protospacer
.*.***************** ***. .

4. spacer 1.2|35981|27|NC_015759|PILER-CR matches to MN693374 (Marine virus AFVG_25M38, complete genome) position: , mismatch: 6, identity: 0.778

ttgattcgctatctgaaatattatctg	CRISPR spacer
taataccgctatctgaaatatgatctg	Protospacer
* .  .*************** *****

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

496102 : 504656

Escherichia_phage(33.33%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_006845911.1\|496102_497704_-	CTP synthase	A0A1J0FA14	Only_Syngen_Nebraska_virus	8.3e-140	47.6
WP_006845912.1\|497889_498483_-	DNA-directed RNA polymerase subunit delta	NA	NA	NA	NA
WP_013989340.1\|498598_499435_-	dTDP-4-dehydrorhamnose reductase	A0A291LA50	Escherichia_phage	1.8e-32	36.6
WP_006845914.1\|499477_500515_-	dTDP-glucose 4,6-dehydratase	A0A1D7XFE8	Escherichia_phage	1.1e-73	46.0
WP_013989341.1\|500528_501122_-	dTDP-4-dehydrorhamnose 3,5-epimerase family protein	A0A218MN57	uncultured_virus	2.5e-09	32.4
WP_013989342.1\|501128_502001_-	glucose-1-phosphate thymidylyltransferase RfbA	I7I009	Enterobacteria_phage	2.5e-98	61.5
WP_081461279.1\|502541_502955_-	glycosyltransferase	NA	NA	NA	NA
WP_148235962.1\|502954_503632_-	glycosyltransferase	NA	NA	NA	NA
WP_013989345.1\|503666_504656_-	glycosyltransferase family 2 protein	A0A1V0SAH6	Catovirus	8.0e-08	34.3

DBSCAN-SWA_2

1199999 : 1209274

Catovirus(16.67%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013989759.1\|1199999_1202396_+	endonuclease MutS2	A0A1V0SC35	Catovirus	1.7e-16	24.8
WP_013989760.1\|1202532_1203372_+	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	3.5e-65	46.1
WP_006845175.1\|1203813_1205022_+	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC	Q9HH70	Methanothermobacter_phage	1.2e-42	34.6
WP_013989761.1\|1205022_1206186_+	hydroxymethylglutaryl-CoA synthase	NA	NA	NA	NA
WP_006845177.1\|1206296_1206737_+	nucleoside 2-deoxyribosyltransferase	A0A1D3SPR3	Enterococcus_phage	5.3e-20	35.6
WP_013989762.1\|1206765_1207665_+	N-acetylmuramoyl-L-alanine amidase	Q9FZW0	Bacillus_phage	4.7e-15	31.9
WP_006845179.1\|1207945_1209274_+\|tRNA	histidine--tRNA ligase	A0A2K9L0H9	Tupanvirus	3.1e-23	26.1

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_015759

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection