CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_015947	Stenotrophomonas maltophilia JV3, complete genome	13 crisprs	DEDDh,csa3,WYL,cas3,Cas9_archaeal,DinG	0	0	3	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_015947_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015947_1

443581-443672

Orphan

Consensus_repeat	Method
CCCCGGCGGCCGATGCCGCCGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015947_1

>merge|NC_015947|1|443581-443672|CRISPRCasFinder
CCAAGCCGGCCGACACCGCTGCCCCGGCGGCCGATGCCGCCGCCCCGGCCACCACCGAGCAGGCCGCCACCCCGGCTGCCGATGCCGCCGCC

>NC_015947|1|1|443581-443672|CRISPRCasFinder
CCAAGCCGGCCGACACCGCTGCC	CCGGCGGCCGATGCCGCCGCCCCGGCCACCACCGAGCAGGCCGCCA
CCCCGGCTGCCGATGCCGCCGCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015947.1\|WP_042358459.1\|453687_453909_-\|hypothetical-protein	unknown	unknown	unknown
NC_015947.1\|WP_014035776.1\|448166_450854_+\|pyruvate-dehydrogenase-(acetyl-transferring),-homodimeric-type	unknown	unknown	gnl\|CDD\|236500
NC_015947.1\|WP_014035778.1\|452081_452660_+\|hypothetical-protein	unknown	unknown	unknown
NC_015947.1\|WP_014035768.1\|440532_441384_-\|DUF2145-domain-containing-protein	unknown	unknown	gnl\|CDD\|227071
NC_015947.1\|WP_014035765.1\|438828_439389_-\|queuosine-precursor-transporter	unknown	unknown	gnl\|CDD\|224652
NC_015947.1\|WP_014035779.1\|452834_453203_-\|hypothetical-protein	unknown	unknown	unknown
NC_015947.1\|WP_014035772.1\|444465_444867_-\|hypothetical-protein	unknown	unknown	unknown
NC_015947.1\|WP_014035766.1\|439464_439977_-\|hypothetical-protein	unknown	unknown	unknown
NC_015947.1\|WP_014035767.1\|440009_440513_-\|hypothetical-protein	unknown	unknown	unknown
NC_015947.1\|WP_014035770.1\|441767_442727_-\|nucleoside-diphosphate-sugar-epimerase	unknown	unknown	gnl\|CDD\|377637
NC_015947.1\|WP_014035762.1\|432192_433557_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319958
NC_015947.1\|WP_014035781.1\|454116_454716_+\|hypothetical-protein	unknown	unknown	unknown
NC_015947.1\|WP_014035769.1\|441432_441663_-\|hypothetical-protein	unknown	unknown	unknown
NC_015947.1\|WP_014035775.1\|447060_447621_-\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NC_015947.1\|WP_014035773.1\|445074_445908_+\|hypothetical-protein	unknown	unknown	unknown
NC_015947.1\|WP_014035771.1\|442853_443444_+\|malonic-semialdehyde-reductase	unknown	unknown	gnl\|CDD\|180040
NC_015947.1\|WP_014035777.1\|450924_452085_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|379114
NC_015947.1\|WP_014035763.1\|433719_435234_-\|acetyl-CoA-hydrolase/transferase-family-protein	unknown	unknown	gnl\|CDD\|274588
NC_015947.1\|WP_014035764.1\|435608_438404_+\|bifunctional-[glutamate--ammonia-ligase]-adenylyl-L-tyrosine-phosphorylase/[glutamate--ammonia-ligase]-adenylyltransferase	unknown	unknown	gnl\|CDD\|236836
NC_015947.1\|WP_014035774.1\|446202_447000_-\|siderophore-interacting-protein	unknown	unknown	gnl\|CDD\|99790

Protein	Function_ID	Function_description	E-value
NC_015947.1\|WP_014035776.1\|448166_450854_+\|pyruvate-dehydrogenase-(acetyl-transferring),-homodimeric-type	gnl\|CDD\|236500	PRK09405, aceE, pyruvate dehydrogenase subunit E1; Reviewed.	0
NC_015947.1\|WP_014035770.1\|441767_442727_-\|nucleoside-diphosphate-sugar-epimerase	gnl\|CDD\|377637	pfam06258, Mito_fiss_Elm1, Mitochondrial fission ELM1. In plants, this family is involved in mitochondrial fission. It binds to dynamin-related proteins and plays a role in their relocation from the cytosol to mitochondrial fission sites. Its function in bacteria is unknown.	2.97511e-93
NC_015947.1\|WP_014035768.1\|440532_441384_-\|DUF2145-domain-containing-protein	gnl\|CDD\|227071	COG4727, COG4727, Uncharacterized protein conserved in bacteria [Function unknown].	3.74707e-86
NC_015947.1\|WP_014035765.1\|438828_439389_-\|queuosine-precursor-transporter	gnl\|CDD\|224652	COG1738, yhhQ, Uncharacterized member of the PurR regulon [General function prediction only].	2.91388e-32
NC_015947.1\|WP_014035771.1\|442853_443444_+\|malonic-semialdehyde-reductase	gnl\|CDD\|180040	PRK05365, PRK05365, malonic semialdehyde reductase; Provisional.	1.36233e-127
NC_015947.1\|WP_014035777.1\|450924_452085_+\|AAA-family-ATPase	gnl\|CDD\|379114	pfam13304, AAA_21, AAA domain, putative AbiEii toxin, Type IV TA system. Several members are annotated as being of the abortive phage resistance system, in which case the family would be acting as the toxin for a type IV toxin-antitoxin resistance system.	3.98044e-26
NC_015947.1\|WP_014035763.1\|433719_435234_-\|acetyl-CoA-hydrolase/transferase-family-protein	gnl\|CDD\|274588	TIGR03458, Propionyl-CoA:succinate_CoA_transferase, succinate CoA transferase. This family of CoA transferases includes enzymes catalyzing at least two related but distinct activities. The E. coli YgfH protein has been characterized as a propionyl-CoA:succinate CoA transferase where it appears to be involved in a pathway for the decarboxylation of succinate to propionate. The Clostridium kluyveri CAT1 protein has been characterized as a acetyl-CoA:succinate CoA transferase and is believed to be involved in anaerobic succinate degradation. The propionate:succinate transferase activity has been reported in the propionic acid fermentation of propionibacterium species, where it is distinct from the coupled activities of distinct nucleotide-triphosphate dependent succinate and propionate/acetate CoA transferases (as inferred from activity in the absence of NTPs). The family represented by this model includes a member from Propionibacterium acnes KPA171202 which is likely to be responsible for this activity. A closely related clade not included in this family are the Ach1p proteins of fungi which are acetyl-CoA hydrolases. This name has been applied to many of the proteins represented by this model, possibly erroneously.	0
NC_015947.1\|WP_014035775.1\|447060_447621_-\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	1.62987e-17
NC_015947.1\|WP_014035762.1\|432192_433557_+\|VOC-family-protein	gnl\|CDD\|319958	cd16348, VOC_YdcJ_like, uncharacterized metal-dependent enzyme similar to Shigella flexneri YdcJ. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	0
NC_015947.1\|WP_014035764.1\|435608_438404_+\|bifunctional-[glutamate--ammonia-ligase]-adenylyl-L-tyrosine-phosphorylase/[glutamate--ammonia-ligase]-adenylyltransferase	gnl\|CDD\|236836	PRK11072, PRK11072, bifunctional [glutamate--ammonia ligase]-adenylyl-L-tyrosine phosphorylase/[glutamate--ammonia-ligase] adenylyltransferase.	0
NC_015947.1\|WP_014035774.1\|446202_447000_-\|siderophore-interacting-protein	gnl\|CDD\|99790	cd06193, siderophore_interacting, Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from transferrin and lactoferrin for bacterial uptake, contributing to pathogen virulence. Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport mechanism of photosystem I. FNR transfers electrons from reduced ferredoxin to FAD (forming FADH2 via a semiquinone intermediate) and then transfers a hydride ion to convert NADP+ to NADPH. FNR has since been shown to utilize a variety of electron acceptors and donors and has a variety of physiological functions including nitrogen assimilation, dinitrogen fixation, steroid hydroxylation, fatty acid metabolism, oxygenase activity, and methane assimilation in a variety of organisms. FNR has an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) flavin sub-domain which vary in orientation with respect to the NAD(P) binding domain. The N-terminal moeity may contain a flavin prosthetic group (as in flavoenzymes) or use flavin as a substrate. Because flavins such as FAD can exist in oxidized, semiquinone (one-electron reduced), or fully reduced hydroquinone forms, FNR can interact with one and two electron carriers. FNR has a strong preference for NADP(H) vs NAD(H).	1.20402e-88

>NC_015947.1|WP_014035771.1|442853_443444_+|malonic-semialdehyde-reductase
MSHALDAAALDQLFRTARTQNAFLDKPVPASLLQELYDLVKWGPTAANTTPARFVFVTSKEAKEKLAPALSEGNLAKTMAAPVTAIIGFDLDFHEKLPYLFPHTDAKAWFDGPQEGRHEAAIRNGSLQGAYLILAARALGLDAGPMSGFDAAKVDEAFFAGTSIKSNFLVNLGYGDPAGLFPRLPRLSFDEAARIA
>NC_015947.1|WP_014035770.1|441767_442727_-|nucleoside-diphosphate-sugar-epimerase
MVKRSSAPWTVTDGRAGNVRQAVALASALRQGTHRPLLLQPRAPWRWLSPRRLPGDVNGYGEAFATLAAEAPALAIGCGRQAAGALRALRARGSQVVQILDPRIGARHWDVVVVPEHDALRGSNVLTLLGSLNPVDDDWLAWGRAAFAGFSTLPGPRTALLVGGPTPLAPWDETAMVGVFQALAEQIRSEGGSLLATTSRRTPPALAEILRAKFADLPHVIWGDGGDGTNPYGGLLGWANRVVVSPDSVNLLSEACATRMPVMVALANTVQGRLARFQQQLRERGRLQTRWLDWQYDRIEPLRETARIAAEVKARLALR
>NC_015947.1|WP_014035769.1|441432_441663_-|hypothetical-protein
MRTLLLLPLALLAACSTAPTELDPISYQCQQQLDAYREQPALRDPKTGERPPLPIAPISDACDKELKRKGVDRPLR
>NC_015947.1|WP_014035768.1|440532_441384_-|DUF2145-domain-containing-protein
MDRFSRLPRAALLIASLLATAPAWANSTECRERYPSVASQAAMLDVAWTTAERLDALPDVDVVVAARGGQDLSRYGLRHSHLAFLLREDDGRWRAMHLLNRCKTDSSQLYHEGLGNFVGESGGHTDLRIGVPSAPLRAALRAMLVSPSIQPKALHETRYNVVAYPFATDYQNSNQWVLEVLAAAMAQAEGAPAIVKREQAQQWLRQQKYQPSVLHIGLGKRVGARLFVANATTTDHPAGERISGNYSVVTVESVFDFLHQRSQLLQELVIPHVPVAGAAAASP
>NC_015947.1|WP_014035767.1|440009_440513_-|hypothetical-protein
MRLLHNSLVSMLIVTALAWSSAAHAERRIVIIHDPGPQGPSLEMSTQMVASARAAAAEEAKDAADAGQPLARPQQIKLPQMEVSGIATTVDGRREVLLRDANDPQNTASMQYPRGIGDPAVQFTVGQTVNFEPTGADQGWQLKDNQGRPLEYLPEATGPRDIFDNRR
>NC_015947.1|WP_014035766.1|439464_439977_-|hypothetical-protein
MFRCLRVPASALLLSALLVPTVHAGAAPQLNSSEASVLITSLIVVSVPLAASAGLSELSKAPFKASERNARAARTKAVPLPPMEVKKVETTPAGERQVQLQVPDKADQTATLRWPARVHEDQTAAFVVGQQVHFDPTEAGAGWTVKSAQGQALAYVPTAYAAGDVMSEAL
>NC_015947.1|WP_014035765.1|438828_439389_-|queuosine-precursor-transporter
MSVRPAPVFAPLTARALVLAVLAMGAVVLLSNVLVQYPINDWLTWGAFSYPVAFLVSNLINRRFGPGPARRVAWIGFAVAVLLSIWVATPRIAIASCSAFIVAQLLDITVFDRLRRGSWWRAPMVATTCSATVDTTIFWSIAFAGSALPWVSWAAGDLAVKLAIGVCLLAPFRALLWKMAPLRAAS
>NC_015947.1|WP_014035764.1|435608_438404_+|bifunctional-[glutamate--ammonia-ligase]-adenylyl-L-tyrosine-phosphorylase/[glutamate--ammonia-ligase]-adenylyltransferase
MTLAPADLPASLQPLVDRALARLAQVLPEPVPAELLLPLTRLAVASDFALDTLVRQPALLAQLAAPGCPPIPAPVLDPLQPSDWPAQIRRWRTAMSTRLIWRDLTGLDDVAQTLAGATTLAEDCLRLALDALQQEFAQRHGVVRDGEGTPQQLVVFGLGKLGGGELNFSSDVDLVYAYPHGGESDGPRALAAEEYFARLGQRLAKLLDETTVDGFSHRVDLRLRPFGSAGRVALSFAAMDQYFQREGRDWERYAWLKARAVAGDIEAGEAWLQTLRPFVYRRYLDFTALDGLREMKAAITAEVARRELHEDIKRGAGGIREIEFLCQALQLIRGGREPTLRERRLLVALDALVAAGQIAPEDGRALREAYLFLRRLENRLQMLRDAQTHVLPSDALDRERIAVGLGYPDWEVLRAALAVQQQRVSTEFAALLAPRKGQAAPDALANYWRSLPEGSNAPLLAEAGFLDANGADQSLRDFAQGTGVKSLSDAARARLDRVLPALLHAATRSPQPDAALKRVLGLLQAVLRRTSYLALLDEQPSALARLVDVLARSALLAERLAAYPLLLDELLDVRVSGPMPDAAGMLAECQQVLAVEDPESALRWLNETRLALSFRMAMATLDGRQGAVDSTRQLAELAQAVVVTVLAMAEADMRAAHGEIPGGRFAIIGYGSLGGLELGFGSDLDLVFLHDNPAGVDASDGTRPLEPGRWYARLAQKVMALLGAVTAAGRLYDIDVRLRPDGGKGSLVSSLASYTEYQRERAWTWEHQALVRARGVAGDASLLADFEQVRAQTLGRERDAGVLYADVLKMRGRMRTELDRSDAARLDLKQGAGGVVDLEFLLQTGVLARSAQHVALLQPRDTPSLIDALSVAGFLPEDTAQALHGAHATLLEVGLACTLDRRPRLAPTTPAIEEACAAITAACSAVELPFA
>NC_015947.1|WP_014035763.1|433719_435234_-|acetyl-CoA-hydrolase/transferase-family-protein
MSVDRIANARLRDRVVSAEAAAALIQPGETVAMSGFTGSGYPKAVPVELARRIEAVHAQGQPFQIKLMTGASTAPELDGALAKADGIAMRMPFQSDPDARNRINEGKLDYIDIHLSHVAQHVWFGFYGEIDTAVIEVSAIREDGSLVPSTSVGNNKTWLDLAKKVIVEVNEWQPAGVDGMHDIYYGTALPPHRKPIPLVNANDRIGDTALRCDPDKIVAVVRTNGPDRNSPFSPIDATSEQIASHLIEFLKHEVKKGRLPPNLLPLQSGVGNIPNAVLAGLAKSGFRDLAAFTEVIQDGMLDLLRDGVLSYASCTGFALSPQANETFKEHIDFYRERIIMRTQEISNHPELVRRLGCIGMNGMIEVDIYGNVNSTHVMGTRIMNGIGGSGDFARNGFLSAFLSPSTAKNGTISAIVPMASHVDHTEHDVSVIVTEQGLADLRGLTPRKRAQVLIDNCAHPDFRPQLQDYFDRASRESYGKHTPHLLPEALSWHQRWLDTGTMKG
>NC_015947.1|WP_014035762.1|432192_433557_+|VOC-family-protein
MSASFVSPDVIRRLFAQAMSRMYRTEVPLYGTLVELVERINAQVLDQDPALAAQLLRNDERARLDEERHGAIRVGTVQELATLRRLFAVMGMFPVGYYDLSVAGVPVHSTAFRPLTGAALAQNPFRVFTSLLRLELIEDEALRAESARILERRRIFTDGALALIDQAERDGGLSQADAERFVDEALETFRWHGDATVDLPTYHALHNAHRLVADVVSFRGPHINHLTPRTLDIDAAQAAMIEHGMAAKAVIEGPPRRACPILLRQTSFKALEEAVHFPDSEGGDAGTHTARFGEIEQRGLALTPKGRALYDQLLSQARDAGGEGSTGGDYGQRLQAVFASFPDDHDTLRQEGLGYYRYQLTYAGRAAPERVADLPAEVLVAAGLATADPIVYEDFLPVSAAGIFQSNLGGEEQRAYAAHANREAFEQALGVAVNDEFEIYERLQAESLASLRTA
>NC_015947.1|WP_014035772.1|444465_444867_-|hypothetical-protein
MAKLTLASVDALRTRFADDAACDTALAAFADTAALRVPLRELVEAQHRYLQAEFEVAQVADVLRRDQKYAPVGRPSINIVQLRKQQAATKQAALIARQVVAQAAQTFVRVSGLAVKAKQSPSEACGVWLGALR
>NC_015947.1|WP_014035773.1|445074_445908_+|hypothetical-protein
MQDAQYWLNEFWTGLSVLDLLGGSVLGTLLGLVLGIVAWRWLHRRGWLQRRKRWHHWLLASYVVLLPLATAFFGLQLGFTAGAHRALFKQLDHFQPHLQTLVEGWSEGFTDSLDDPRMREALRSQGTVGDVADTIASAYLSEHPLPGLDRLGNGPLARGTGWVIGKVREGLLRGMVEDTLVDKAGTIGLEPKVVREALTMHVDELLHTRGVLRLVKAQINGMMPGVYFGLLLPLLIIALLVALEIWAAQRFGWTRQVASSVVVPAAGLQLQVPAEGS
>NC_015947.1|WP_014035774.1|446202_447000_-|siderophore-interacting-protein
MTEHNNTRLRLDVRFRELTVLRTEDVTPHMRRVVLGGDDLAGFDSPGADDHIKLFFPNASGEMVLPVLTAEGRSYPAGKEPSPSRDYTPRWWDHETGELAIDFVLHDQGIAGPWAEQAQAGDVLVIGGPRGSFVVADSYDAYVLIGDETALPAIARWLDVLPDGAEVQAFIEVSDEAERQDLPQYENVRIHWLERNGFPAASSTLLEDMLTDFEAPDGDVFYWIATESRRARMMRKFIEGHLGVPRDWIRSTGYWKAHPDETDGD
>NC_015947.1|WP_014035775.1|447060_447621_-|PadR-family-transcriptional-regulator
MSRTASPRARSTDPAVPRRNGQPRVLSRGDLRLLVLALIGEQPRHGYELMQLISNQFMQAYTPSAGTMYPLLASFEQAGWIEAEEVDGKRIFRITAAGEFELKVQRTQVRLAQRRAFDRAREITKASLPPPLATALREFKRALVHHHGRWAEGEADEVAALLTRASALLNGTAGSEASPLSTTQPD
>NC_015947.1|WP_014035776.1|448166_450854_+|pyruvate-dehydrogenase-(acetyl-transferring),-homodimeric-type
MNWLNEVLNNDPNPVETQEWIESLKAVIDVEGSERAHQLLEGMVELTRRSGAYLPFSPTTEYVNTIEPQLEAKSPGNAELEWRIRSIIRWNAMATVVRANRKPGDLGGHIASFASGATLYDVGFNHFWRAPSENHPGDLLFIQGHSAPGIYARSFLEGRISEEQLDKFRMEVDGGGLSSYPHPWLMPDYWQTPTVSMGLGPLAAIYQAQFMRYLENRGLIEKSDRKVWCFIGDGESDEPETLGAIALAGREGLDNLIFVVNCNLQRLDGPVRGNGKIIQELEGVFRGGGWNVIKLLWGGYWDALLAKDTNGVLKKLMMETVDGEYQNCKAFGGAYTREHFFGKYPETAAMVAGLSDDDIWRLNRGGHDPHKVYAAYHQAVNTKGMPTVILAKTVKGYGMGSAGEALNPTHQTKKLDDEAVRHFRDRFNIPVTDAQLADGQVPFYHPGPDSPEVQYLQERRAALGGYLPQRRRKADKTFVAPKLEAYERLLKSSGERSYSTTMAFVQSLNITLRDKELGPHIVPIVADEARTFGMEGLFRQIGIYAPFGQKYKPVDADQLMFYREDQSGQVLQQGISEPGAISSWMAAGTSYSVSNVPMLPFYIYYSMFGFQRVGDIAWQAADMRTRGFLLGGTAGRTTLNGEGLQHEDGFSHLVAGGIPNVRSYDPTFGFEVTVVLQHGTKRMMEDQVDEYYYVTLMNENYTHPEMPEGAAEGIVKGMYLLTDAGKPKKGELRVQLLGSGTILREAIAAAELLDKDFGVTADIWSCPSFNELRRDGFDVERANRLHPEGEQRKAYVTELLEGRQGPAIAATDYVRAYADQIRAFVPMSYTVLGTDGFGRSDTRANLRRFFEVDRYYIAHAAIAALAKEGKMTAKDVARAIKQYKIDPEKANPVGV
>NC_015947.1|WP_014035777.1|450924_452085_+|AAA-family-ATPase
MIVTHLKLRNWRNFREVDVPLRERTYLLGANASGKSNFLDVFRFLRDVSKSHGGGLQKAVHDRGGIQKLRCLHARRDPEVRIEIELSENAEDDAPTWKYVLGFRPEGKGAQRTIVSREQVFRNGRPVLDRPDDKDRADEVRLTQTALEQIQANVKFRELAEFFGETTYLHLVPQLLKYADRIGGQLLEDDPFGQGFLERVAKTQPRARDSRLKKIGKALALAVPQFKELRFAPDPVNGRPHLEALYSHYRPNAGWQREEHFSDGTLRLLGLLWVLIEGDSLLLLEEPELSLNDAIVREIPLLLTRIQRDRKRKNRQIIVSTHSEALLSNPGIDARGVLLLEPVVEGTVIRPVNEKEAVALNAGLSVAEVILPKTRPTSIEQLGFWE
>NC_015947.1|WP_014035778.1|452081_452660_+|hypothetical-protein
MTEIAIATEDILTEVVCERIASELGLKVFMRLRKGGCGYLKSRIGSFIEMARQYPVLVVTDLDDKVCAEALVRQWVAGRQVSDKFFLRVAVREVESWIMADRDGFGAFIGARIDFDPEQLPDPKAKLLNLALQAPRTIREELISQRSAIASQGVGYNTKLSEFVVEHWCPRRASVASDSLRRTVERLSSLLS
>NC_015947.1|WP_014035779.1|452834_453203_-|hypothetical-protein
MNTSDFRSLHAQYDPDNAEAEREPSVDPNAFVATLRRIGSGAAADGQPWPERHQLPGRCLQLADADCALAGLRVVAELMLAAERTRQNGAPEEYLGDRMMEGLKMACVALTAQVAERLHVRE
>NC_015947.1|WP_042358459.1|453687_453909_-|hypothetical-protein
MTMTTIDTAWQEAFDKELLYLFAIDHGDAGMDEYQLGCYADLPPREAALAFGSDYDLERDDALWPRPVVAAES
>NC_015947.1|WP_014035781.1|454116_454716_+|hypothetical-protein
MVLLPLLMGGCGTQAPQMYGDGFPVAKPMDLVHAGATVEARFELPPPWEKETKPRTFLIGFRTGGPAKRPDMKPGDVAFLEDARIPLKVQLWKLEGDTETPIALQVLNRDLPAVWQGSRYQPAKGDVYEYRSAVGADSNSLVKAGKYDMALAYREYEVARADSEDLTAGKYRLKVTNLQANPDVAHLNIELLVANYNVK

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Crispr_ID: NC_015947_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015947_2

473572-473694

Orphan

Consensus_repeat	Method
GGCATCCACGCATGGCGTGGATCTACTGTGGGCCGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015947_2

>merge|NC_015947|2|473572-473694|CRISPRCasFinder
GGCATCCACGCATGGCGTGGATCTACTGTGGGCCGGGTGTGGTGGGCCAGGCGTCCGGTAAGTCGAGCATGGCTCGACTCTACAAGGGCATCCACGCATGGCGTGGATCTACTGTGGGCCGGG

>NC_015947|2|2|473572-473694|CRISPRCasFinder
GGCATCCACGCATGGCGTGGATCTACTGTGGGCCGGG	TGTGGTGGGCCAGGCGTCCGGTAAGTCGAGCATGGCTCGACTCTACAAG
GGCATCCACGCATGGCGTGGATCTACTGTGGGCCGGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_015947.1\|WP_014035808.1\|479359_480733_+\|D-serine/D-alanine/glycine-transporter	unknown	unknown	gnl\|CDD\|236830
NC_015947.1\|WP_014035805.1\|474838_476017_+\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NC_015947.1\|WP_005412102.1\|485576_485984_-\|YciI-family-protein	unknown	unknown	gnl\|CDD\|226318
NC_015947.1\|WP_014035802.1\|470358_471684_+\|GTP-binding-protein	unknown	unknown	gnl\|CDD\|223597
NC_015947.1\|WP_014035797.1\|467616_468036_-\|hypothetical-protein	unknown	unknown	unknown
NC_015947.1\|WP_042358465.1\|466259_467102_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225319
NC_015947.1\|WP_014035811.1\|483517_485599_+\|gluconolaconase	unknown	unknown	gnl\|CDD\|271323
NC_015947.1\|WP_157355476.1\|486191_486407_-\|hypothetical-protein	unknown	unknown	unknown
NC_015947.1\|WP_014035796.1\|467166_467547_-\|hypothetical-protein	unknown	unknown	unknown
NC_015947.1\|WP_014035809.1\|481052_481829_+\|lytic-transglycosylase-domain-containing-protein	unknown	unknown	gnl\|CDD\|381594
NC_015947.1\|WP_014035800.1\|469555_469840_+\|metal-sensing-transcriptional-repressor	unknown	unknown	gnl\|CDD\|197388
NC_015947.1\|WP_014035810.1\|481836_483357_-\|hypothetical-protein	unknown	unknown	unknown
NC_015947.1\|WP_014035807.1\|477512_479129_-\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|227279
NC_015947.1\|WP_014035803.1\|471762_473370_-\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NC_015947.1\|WP_014035806.1\|476013_477198_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|225371
NC_015947.1\|WP_014035801.1\|469917_470289_-\|MerC-domain-containing-protein	unknown	unknown	gnl\|CDD\|377004
NC_015947.1\|WP_014035794.1\|465287_466256_+\|polysaccharide-deacetylase-family-protein	unknown	unknown	gnl\|CDD\|200583
NC_015947.1\|WP_014035799.1\|468530_469505_-\|CDF-family-Co(II)/Ni(II)-efflux-transporter-DmeF	unknown	unknown	gnl\|CDD\|224151
NC_015947.1\|WP_014035804.1\|473710_474610_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176165
NC_015947.1\|WP_014035798.1\|468126_468411_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_015947.1\|WP_014035808.1\|479359_480733_+\|D-serine/D-alanine/glycine-transporter	gnl\|CDD\|236830	PRK11049, PRK11049, D-alanine/D-serine/glycine permease; Provisional.	0
NC_015947.1\|WP_014035807.1\|477512_479129_-\|EAL-domain-containing-protein	gnl\|CDD\|227279	COG4943, COG4943, Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms].	6.07941e-166
NC_015947.1\|WP_005412102.1\|485576_485984_-\|YciI-family-protein	gnl\|CDD\|226318	COG3795, COG3795, Uncharacterized protein conserved in bacteria [Function unknown].	3.84687e-33
NC_015947.1\|WP_014035802.1\|470358_471684_+\|GTP-binding-protein	gnl\|CDD\|223597	COG0523, COG0523, Putative GTPases (G3E family) [General function prediction only].	5.5373e-107
NC_015947.1\|WP_042358465.1\|466259_467102_-\|hypothetical-protein	gnl\|CDD\|225319	COG2521, COG2521, Predicted archaeal methyltransferase [General function prediction only].	1.13331e-99
NC_015947.1\|WP_014035811.1\|483517_485599_+\|gluconolaconase	gnl\|CDD\|271323	cd14953, NHL_like_1, Uncharacterized NHL-repeat domain in bacterial proteins. This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.	1.27578e-98
NC_015947.1\|WP_014035809.1\|481052_481829_+\|lytic-transglycosylase-domain-containing-protein	gnl\|CDD\|381594	cd00254, LT-like, lytic transglycosylase(LT)-like domain. Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.	6.04102e-44
NC_015947.1\|WP_014035800.1\|469555_469840_+\|metal-sensing-transcriptional-repressor	gnl\|CDD\|197388	cd10153, RcnR-FrmR-like_DUF156, Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156. This domain family includes various transcriptional regulators that respond to different stressors. It includes Escherichia coli RncR (formally known as YohL, nickel and cobalt-sensitive), and E. coli FrmR (formally known as YaiN, formaldehyde sensitive). Escherichia coli RncR represses expression of the gene encoding the nickel and cobalt-efflux protein RcnA; RcnA may act through modulating NikR, to repress the NIkABCDE nickel transporter. In vitro, purified RncR binds to the rncA promoter DNA fragment in the absence of Ni2+ or Co2+, and the affinity of RncR for this promoter is reduced in the presence of excess nickel. Escherichia coli FrmR regulates the formaldehyde degradation frmRAB operon. This family belongs to a larger superfamily that includes CsoRs (copper-sensitive operon repressors). CsoRs form homotetramers (dimer of dimers). In Mycobacterium tuberculosis CsoR, within each dimer, two Cys residues on opposite subunits, along with a His residue, bind the Cu(I) ion (forming a triagonal S2N coordination complex, C-H-C). These residues are conserved in the majority of members of this superfamily. In this family, however, not all these residues are conserved; in E.coli RcnR and FrmR there is a His or a Thr instead of the second Cys (C-H-H or C-H-T) respectively. For E. coli FrmR, an N-terminal His residue, not conserved in all members of this family, is also involved in metal binding (H-C-H-H). A conserved Tyr and a Glu residue that facilitate allosteric regulation of DNA binding for CsoRs are poorly conserved in this family.	5.49438e-27
NC_015947.1\|WP_014035805.1\|474838_476017_+\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	1.62654e-55
NC_015947.1\|WP_014035803.1\|471762_473370_-\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	3.70868e-106
NC_015947.1\|WP_014035806.1\|476013_477198_+\|MFS-transporter	gnl\|CDD\|225371	COG2814, AraJ, Arabinose efflux permease [Carbohydrate transport and metabolism].	1.03616e-66
NC_015947.1\|WP_014035801.1\|469917_470289_-\|MerC-domain-containing-protein	gnl\|CDD\|377004	pfam03203, MerC, MerC mercury resistance protein.	2.85058e-13
NC_015947.1\|WP_014035794.1\|465287_466256_+\|polysaccharide-deacetylase-family-protein	gnl\|CDD\|200583	cd10960, CE4_NodB_like_1, Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases. This family includes many uncharacterized bacterial polysaccharide deacetylases. Although their biological function still remains unknown, members in this family show high sequence homology to the catalytic NodB homology domain of Streptococcus pneumoniae polysaccharide deacetylase PgdA (SpPgdA), which is an extracellular metal-dependent polysaccharide deacetylase with de-N-acetylase activity toward a hexamer of chitooligosaccharide N-acetylglucosamine, but not shorter chitooligosaccharides or a synthetic peptidoglycan tetrasaccharide. Like SpPgdA, this family is a member of the carbohydrate esterase 4 (CE4) superfamily.	6.69864e-101
NC_015947.1\|WP_014035799.1\|468530_469505_-\|CDF-family-Co(II)/Ni(II)-efflux-transporter-DmeF	gnl\|CDD\|224151	COG1230, CzcD, Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism].	6.09532e-75
NC_015947.1\|WP_014035804.1\|473710_474610_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176165	cd08476, PBP2_CrgA_like_7, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold. This CD represents the substrate binding domain of an uncharacterized LysR-type transcriptional regulator (LTTR) CrgA-like 7. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	6.52204e-100

>NC_015947.1|WP_014035803.1|471762_473370_-|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MTTHSLTLDRVSYRLADGRPLFSDLSFSFEPVATGLVGANGTGKSVLARLLAGHLLPDSGQIRSSGRVFLLPTPGYPPTGTVGQLAGVGAELAALQRIEAGSVDETDFACVGERWDLRERLQQQWQVLRLPGDLDPAQPAARLSGGQAMQVALSGAWASGADWLILDEPSNHLDARHRQQLYQQLQQWRGGLLVISHDRELLAQMQQIVELDARGLHRYGGPWQHYADARAAEREAAAAQLDHARAQHRQQQRSAREQHERQQQRQARGNRDAKQANQAPILLGRQKQRAEASHGRAQQVQAERLQASADQLRAAASAVHATPELALFAGDGERGSARLLQVDSLVLPHGCSAPLQLEIRRGQRIAVIGDNGSGKSTLLRVLAGQLPARSGTVQRHAPLALLDQQLLGLSGECSILDTVQAANPAADTGELRTRLALLGLDAQRIQRAAHSLSDGERVKGALASVLYADPAPQLLLLDEPGNALDLSALQALEELLAAWPGALVMVSHDRHLLQALQPTQVLQVTANSWQWRDAL
>NC_015947.1|WP_014035802.1|470358_471684_+|GTP-binding-protein
MNTVSRADRRLPVTVLSGFLGAGKTTLLNQILRNREGLRVAVIVNDMSEVNIDAQLVREGGAELRRTEETLVEFSNGCICCTLRDDLLQEVRRLADAGRYDYLLIESTGIGEPMPVAATFAVRDEQGFSLSDIARLDTMVTVVDGSAFLTDFGSTLRLAERGQQAGPDDDRGVVDLLCEQVEFADVIVVSKIDQVDDEVLQDTLAVLRGLNRDAKLLLSSFGDVPLAELLDTGRFDYERAQRAPGWVKELRGEHTPETEEYGIASFVYRSRRPFHPARFARALQSGMPGVIRSKGWFWLANRMDWVGELNTVGAATRTQAAGFWYAARDRVRAGLEDTAPLLPPTPLPYSDLGWARQQADCWSAPLPGLEEFPDVAAHSAMQRLWHPLWGDRRQELVVIGVHMDERAVRAELDACLLNEQELRAGPLLWHQLPQAFPVWKR
>NC_015947.1|WP_014035801.1|469917_470289_-|MerC-domain-containing-protein
MKSPSAALLDAGAVALSSLCLLHCLALPLLAAALPLLGTWAEAEWVHLLFVAIALPLTGYALWRAERRHPLPVLAWATAGAGLGLLLAGALALPSHDWETPMTVTGSLLLAATHIWNARHRHG
>NC_015947.1|WP_014035800.1|469555_469840_+|metal-sensing-transcriptional-repressor
MAHVHKHRKQLLTRVRRIGGQVAALEQALDRPEGEAGDCANVLVQVAAVRGAAHSLLMELLHEHLQEHVVGAEDPQQRADEAAVLVELLRRYGK
>NC_015947.1|WP_014035799.1|468530_469505_-|CDF-family-Co(II)/Ni(II)-efflux-transporter-DmeF
MHLDALAAARRHEHRFDDGNPLAERNTRRALWLTVCMMLVEIVGGWWFNSMAVLADGWHMSSHALALGLSVFAYRCARRYAHDPRFAFGTWKIEILAGYTSAIALLGVAALMAVQSLERLWVPAPIHYNEAIAIAAVGLGVNLLCAWWLHDSPGHAHHHHGHEHGHHHGHDHDHHDHSHAHGHDLNLRSAYVHVLADAATSVLAIVALLGGKLLGLTWLDPVMGLVGAVLVTVWAIGLLRDSGRILLDAQMDAPVVAEVREVIEQGPWPARLADLHVWQVGRGKYAVSASVVTSDASLDADAVRKALAIHEELVHVTVEIHRSA
>NC_015947.1|WP_014035798.1|468126_468411_+|hypothetical-protein
MAQGKAPWCGVGSWLGIAVGWGAGTVAAQAAVAAGGNGMAAGLGVGVLGAALVGCGLAVAARVRGERWPWIGIAGAVLSALPLLMYLLRMMLKL
>NC_015947.1|WP_014035797.1|467616_468036_-|hypothetical-protein
MRTLRLLLPGALLLLTAACSGDAGLPFSADPLQGCFATSARKPADFRIDKEGGQYFVSFSRGEQWQREPNALHKANRSEISRYFRDDAGQIDNALIRMAGGFGIFHFNKGATLKGKASDSDYMALMLIGAGPVYAVKCP
>NC_015947.1|WP_014035796.1|467166_467547_-|hypothetical-protein
MLLFLLLAVSAPKTQGAYDEVRELPDGQILIMRTLDWDLGGGTKERVTVHWLLQEDGRMRYNFDRQPPETQEAHRRSCARLGMQPSRGVGMIAGEGATHGYSCTSGSVGPTLDSALPASTHGVDLL
>NC_015947.1|WP_042358465.1|466259_467102_-|hypothetical-protein
MSHYTGPLLTRDSADTLRRAHDKGATEWQGSLDLGRSQDTVVLHADGFHFRGQPYPWPGKLKDRTLYYWDGEAFEPISRYSGSLIKLVPTEWGAPTFEIDGIKMLPTSKLSPFEDARRKVELVAPAGKVILDTCGGLGYFAACALEAGVGQIRSFEKNADVMWLRTLNPWSPDPDSAAAGGRLQFSHGDVSQQIEQVASNSVDAILHDPPRFGIAGELYSQVFYDHLARVIRKGGRLFHYTGAPNKLTSGRDVPREVAKRLEKAGFKAELALDGVLAVKR
>NC_015947.1|WP_014035794.1|465287_466256_+|polysaccharide-deacetylase-family-protein
MRFLLRALPLLLCSLAVHAAEVDRRIAVTIDDLPWARLDQITPPDLQARHAALMAQLHQAGVPVVGFVNENKLEVDGQVQPARVQMLRDWRDAGYVLGNHTYSHMDLNAKGVPAFQQDFLRGEAVLRPLLAEKGQAPQWMRHPYLRAGRTPEERAQMDAFFKQHGYRVAPVTVDNGEWVWAFAYANVMNEQADSPAREATLAQLRKGYVPYMLNKLDYYEKQSQALLGYALPQVWLMHANELNAATFAELVAATKRRGYRFISLDEAMRDPAYARGAEGYNGRYGPSWLHRWAMAEKKPKDFYAGEPEVPAWVMKLAKVDSE
>NC_015947.1|WP_014035804.1|473710_474610_-|LysR-family-transcriptional-regulator
MSVLDNLDNLQTFVHAADTRSFVETGRLQGISASAAGKCVARLEHALGVRLFHRSTRSITLTAEGQLFLARCRRILDERDAARTELAQPHAAPSGTLRIGLPLVGDLTLPLMAEFMAAYPDIRLDLDFSDRLVDVIEEGFDAVLRVGEPSDSRMNARRLGVFPRRIVASPAYLQRRGTPRTPAELLQHTLLHYRFPSTGKLELWPIHWPDEETPQELPVHMVANTIEARVALALRHVGLAFVPVHSVRDALADGRLVTVLDEHVHSCGIFHLLWPSGRHVLPKLRVFIDFVSARLETVP
>NC_015947.1|WP_014035805.1|474838_476017_+|serine-hydrolase
MNAALSLEPAPTLPSVQRLLQQVHPLRLVGAVVLVREHGVLRHASATGLADRESALPMQRDQLFRLASVSKPLLTTVILRLVAEGVLDLDAPVQRWLPDFRPALADGRTPPISLRQLLSHSSGLGYRFLEADAEGPYARAGVSDGLDANPLSLAENVRRIAQAPLLFEPGSQWLYSLGVDVAGAVAEAATGETLQVLFGRLLAAPLGLRDTAFATREGARLATPYVSDAPQPHRLREGEVVAPFEGTVGIAYSLARALDASRFASAGAGLVGTADEVMVVLEALRDVQRSGLLPPALAAEMASPQVGEQGPPEPAGWGFGLGFAVLRDAAASGTPQREGTWRWGGAYGHSWFVDPSRGLSVVALTNTLYEGMDGDFVDELRDAVYADLETVR
>NC_015947.1|WP_014035806.1|476013_477198_+|MFS-transporter
MSGHAIDAASPAGEATRLPWAGLLALAGGGFITLLTETLPAGVLRPMGDSLGVSDAAVGQLVSVYALGSVMAALPMTALTQRLPRRPLLLAAIAGFVVVNTLTALSSSYALILAARFLAGVSGGLLWSLVAGYAARMVVPSLQGRAIAVAMVGSPLALSLGVPAGTLLGQQIGWRWAFALMSVLGVGLLAYARWTLPALPAASAGQRTSLATVWRMPGVRSTLLVMMLYVLAHNVLYTYIEPLAVDAGAGAWLDRLLLAFGVAAIAGIGIAGWGVDRHLRALVWAAVIGFIVPVLTLLVWPGAATALLLATILWGVAFGAVPTLFQTALARRAGAAADLAQSMLVTGWNLAIAAGGVAGGVLLQASGPRQLGWLPLLLLAVTVAWLLARPKAWA
>NC_015947.1|WP_014035807.1|477512_479129_-|EAL-domain-containing-protein
MSRLRVIIGGTALALLAAAVPIAVMAYATWDRAVSVEQQRLRDIADRTLRRSDLSYQEALAALKSAEAGAYVPCSPEHVRRMQTLVMTTPSIDQMGYFEGGKLRCTSWGPFLSDVDQPTPDHVTSDGAGIAVDVRPENSGRRQVLAILYGSYDALVDPRRFVDVIADPNVRLALASPDGRLLAQQPGLDPHLLQALLRDPGEGLDHSTLYATSRNEEWLAIATTPRTALAAAFRQQAWLYVPLGLLLAAAGAGLVIWLSRRRLSLRGELATAIRRRELYLHYQPIIELDTGICVGAEALVRWQRPDGTQVRPDLFIPLAEEAGMIADVTDLVIENVVRDMRELLVADRSAHIAINLAAEDISSGRALKMISRHMAGSGILPQQIWMEATERGFLDLDRARTMLAQARRTGHSVAIDDFGVGFSSLQYLEQLPLDALKIDKSFIDAIGTESATSPVTPHIIDMAKELGLWVVAEGVETEAQLAYLHSRHVEFGQGWLFSRPLPRDEFVAFHHKRQQQYGAAREHMQNPRSVPIEREGIE
>NC_015947.1|WP_014035808.1|479359_480733_+|D-serine/D-alanine/glycine-transporter
MTEPATPPEHLRRSLSNRHLQLIAIGGAIGTGLFMGSGKTISLAGPSIVFVYLIIGAMLFFVMRAMGELLLSNLQYKSFIDFSTDLLGPWAGFFCGWTYWFCWIVTAIADVIAIAAYAQFWFPGLEAWKPALACVMLLLALNLVTVKLFGEMEFWFALIKIVAICALIITGAGLVAWGFTSPSGHTASLSNLWNDGGMFPMGLVGFFAGFQIAVFAFVGIELVGTTAAETADPERNLPKAINSIPVRIIIFYVLALIAIMAVTPWRQVVPDKSPFVQLFVLAGIPAAASLINFVVLTSATSSANSGIFSTSRMLYGLAEEGHAPRGLSKLSRAAVPARGLLFSCLCLLGGTLLIYLIPNLVTAFTLVTTLATVLFIFVWSLILVAYMAYRRRYPERHAASIFKMPGGVAMCWACLVFFAGVLVLLSLQGDTRQALIASPAWFVLLGVGYWVRRRTAK
>NC_015947.1|WP_014035809.1|481052_481829_+|lytic-transglycosylase-domain-containing-protein
MSRRPLLLALLLLPSLWPGPAAARTVYRCVQGNTVSLATAPEPGSRCTAREIDDNAIQTPNLWGNMGVFSGVLYEREQDGTLVYSTRNLPGSRVFLKFTVATPPGEPAHEGLGKVGKPQLAQHARQFKAAAKATGVDDAWLRAIAHAESNFDALAVSSKGAQGVMQLMPDTALEYGVSDPFSPQQSIEGGARYMRALLRRYNGDRPLAAAAYNAGIGAVTRYKGVPPYAETLAYVDKVMALYARYREAMGIRTEVPAR
>NC_015947.1|WP_014035810.1|481836_483357_-|hypothetical-protein
MPRIIPLAALLLAALASTPATASITVAPQKPSATADAVHAAYATRWDEAIQQARSGNTLGALISMERLMEDPLLDDFDAEHRGRAAQVAGWTALMQKKPDQARRYLQRAQEALPEDAQVLLTQVSVELSDNQPAAATTFLVKALQHADAPLPVDHHAINYLQYRLRDQPQQRMDLLQALFDNGWKSGGLEPTGLWLALATLQADNGRGDGIPATLARIDSPAEIIRLRSDKRFDRYVDRGDARFDPVQAAQRHLDQLRVSGLLDRALDARMAEFSTTLLMLDRNEEVLSLTEGMAGAASNGEVPSAAEAEWVAWLLNSRLTALRRLGRTDEALATAKQAARIGALGPDGVEHQMNVGFVFSSLGRMQDAAQAVNDMPGLAGYGKAAQALLQFAAARERGDAKARDAARAVILAQRDDARLFHREMLLEEGNLDGAAAVLIEQLRSPVERGETLASLQDMRTYPSLPGDVRIDAAWRALKQRADVQAEVARVGRIERYDLVSTSTSR
>NC_015947.1|WP_014035811.1|483517_485599_+|gluconolaconase
MARWQWMAAGVAVATAVALAATWWERPLHTLAEPAGPAPTPLAWTAQIEPLAGDGHPGDRDGGSAQARFADPYALLRGADGSIYFTDAGDNNRIRRRLPDGRVETVAGQGEGRVDGPALQASFNTPSGIAADVQGNLYVADTGNHAIRRISTDGQVTTLAGGEQGHADGPAAQARFDAPMGIAVDAQGQVYVADTFNDRIRVIGTDGSVRTLAGGDRPGFADGVGTAARFDTPVALAFDAHGALLVADLFNNAVRRVGADGTVSTVVAAGGVINGPLSLATTHDGVLYVGDLDGRIVQVTPQGHQIALVGNGRLPRLARPSGLAMDADGSVLVADAASYRLHRLRPLPVGDLPAPALVGPAADAALPKTGGRWPLAPQEGWHEVVGTLGEVRGNFSGESRHHLHGGFDVRGDVGQTVLAIADGKISSPVAAWNLGEQAEGLAVDRLKYIHMRVGRTPRDQPFDARWQALYDEQGKLERMRVRRGMRIHAGDRLGSINNQAHVHLAVGTGGFETNAVALGFHNYADHFAPRITDVALLDDNDQPMAAGSDGVVMVARQGRGVQIVIEAWDQVDNNLPRRRLGMYQVGYQILDAAGQPLQGYEQPRWNIVFNRMPPQKEAVRVAYAPDSGITVHGSAVTRFRYLATNTVRDGLMETGRWQPAALPPGEYTVRASVRDYSGNEGVGPREIRVRLLP
>NC_015947.1|WP_005412102.1|485576_485984_-|YciI-family-protein
MQQYLLLIYIEPALLQALPTEEFNALMRDCLAHADKLQAEGTLLAAQKLQPVDTAQTLRVRDGHSRVLDGPFAETRELLAGFNLIVARDRDEAMRIARDFPWARFGSIEVRPLEDMDAERERCGAPAAAMAAAVL
>NC_015947.1|WP_157355476.1|486191_486407_-|hypothetical-protein
MDKFLSPFHHGKIKKKNKSNSNGGWLAASALRAKRPASALVVDFPWWFGDRNLSGVGRVGLAGYPRHGWRG

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Crispr_ID: NC_015947_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015947_3

525145-525247

Orphan

Consensus_repeat	Method
GGTGGGTGCCGACCGTTGGCCGGCAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015947_3

>merge|NC_015947|3|525145-525247|CRISPRCasFinder
GGTGGGTGCCGACCGTTGGCCGGCACTCTTTGCTGCTTTGGTGGGTGCCGACCTTGGTCGGCGCGCCACAAATCTCCGGTGGGTGCCGACCGTTGGTCGGCAC

>NC_015947|3|3|525145-525247|CRISPRCasFinder
GGTGGGTGCCGACCGTTGGCCGGCAC	TCTTTGCTGCTTTGGTGGGTGCCGACCTTGGTCGGCGCGCCACAAATCTCC
GGTGGGTGCCGACCGTTGGTCGGCAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015947.1\|WP_014035849.1\|524460_525144_+\|HAD-family-phosphatase	unknown	unknown	gnl\|CDD\|223710
NC_015947.1\|WP_004140558.1\|515881_516361_-\|AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|183009
NC_015947.1\|WP_014035859.1\|535199_535778_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
NC_015947.1\|WP_014035841.1\|516510_517815_+\|D-amino-acid-dehydrogenase	unknown	unknown	gnl\|CDD\|234819
NC_015947.1\|WP_014035848.1\|523762_524464_+\|pseudouridine-synthase	unknown	unknown	gnl\|CDD\|211327
NC_015947.1\|WP_014035852.1\|527171_528266_+\|DNA-polymerase-IV	unknown	unknown	gnl\|CDD\|235035
NC_015947.1\|WP_014035847.1\|522701_523766_+\|methyltransferase	unknown	unknown	gnl\|CDD\|368316
NC_015947.1\|WP_014035855.1\|530328_531258_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176114
NC_015947.1\|WP_014035843.1\|518983_519550_-\|DUF3016-domain-containing-protein	unknown	unknown	gnl\|CDD\|378666
NC_015947.1\|WP_014035854.1\|529581_530220_-\|NAD(P)H-binding-protein	unknown	unknown	gnl\|CDD\|225462
NC_015947.1\|WP_014035856.1\|531254_532046_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|369777
NC_015947.1\|WP_014035850.1\|525257_526466_-\|beta-ketoacyl-ACP-synthase-I	unknown	unknown	gnl\|CDD\|181184
NC_015947.1\|WP_014035857.1\|532122_532791_+\|phosphoglycolate-phosphatase	unknown	unknown	gnl\|CDD\|237310
NC_015947.1\|WP_014035858.1\|532877_534719_-\|TonB-dependent-vitamin-B12-receptor	unknown	unknown	gnl\|CDD\|273802
NC_015947.1\|WP_042358473.1\|519794_521783_+\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|236842
NC_015947.1\|WP_014035846.1\|522279_522543_-\|hypothetical-protein	unknown	unknown	unknown
NC_015947.1\|WP_014035845.1\|521826_522117_+\|DUF3247-family-protein	unknown	unknown	gnl\|CDD\|371627
NC_015947.1\|WP_014035851.1\|526465_526981_-\|3-hydroxyacyl-[acyl-carrier-protein]-dehydratase-FabA	unknown	unknown	gnl\|CDD\|179953
NC_015947.1\|WP_014035842.1\|517793_518861_+\|alanine-racemase	unknown	unknown	gnl\|CDD\|143500
NC_015947.1\|WP_014035853.1\|528578_529490_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293825

Protein	Function_ID	Function_description	E-value
NC_015947.1\|WP_014035849.1\|524460_525144_+\|HAD-family-phosphatase	gnl\|CDD\|223710	COG0637, COG0637, Predicted phosphatase/phosphohexomutase [General function prediction only].	2.0642e-59
NC_015947.1\|WP_004140558.1\|515881_516361_-\|AsnC-family-transcriptional-regulator	gnl\|CDD\|183009	PRK11169, PRK11169, leucine-responsive transcriptional regulator Lrp.	2.64371e-69
NC_015947.1\|WP_014035859.1\|535199_535778_+\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	1.06592e-34
NC_015947.1\|WP_014035841.1\|516510_517815_+\|D-amino-acid-dehydrogenase	gnl\|CDD\|234819	PRK00711, PRK00711, D-amino acid dehydrogenase.	0
NC_015947.1\|WP_014035848.1\|523762_524464_+\|pseudouridine-synthase	gnl\|CDD\|211327	cd02553, PseudoU_synth_RsuA, Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. E.coli RsuA makes psi516 in 16S RNA. Psi at this position is not generally conserved in other organisms.	2.43911e-74
NC_015947.1\|WP_014035852.1\|527171_528266_+\|DNA-polymerase-IV	gnl\|CDD\|235035	PRK02406, PRK02406, DNA polymerase IV; Validated.	0
NC_015947.1\|WP_014035847.1\|522701_523766_+\|methyltransferase	gnl\|CDD\|368316	pfam05175, MTS, Methyltransferase small domain. This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.	1.00675e-67
NC_015947.1\|WP_014035855.1\|530328_531258_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176114	cd08422, PBP2_CrgA_like, The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain. This CD includes the substrate binding domain of LysR-type transcriptional regulator (LTTR) CrgA and its related homologs. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis further showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.28541e-83
NC_015947.1\|WP_014035843.1\|518983_519550_-\|DUF3016-domain-containing-protein	gnl\|CDD\|378666	pfam11454, DUF3016, Protein of unknown function (DUF3016). This is a bacterial family of uncharacterized proteins.	2.11843e-65
NC_015947.1\|WP_014035854.1\|529581_530220_-\|NAD(P)H-binding-protein	gnl\|CDD\|225462	COG2910, COG2910, Putative NADH-flavin reductase [General function prediction only].	3.10219e-67
NC_015947.1\|WP_014035856.1\|531254_532046_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	1.91509e-16
NC_015947.1\|WP_014035850.1\|525257_526466_-\|beta-ketoacyl-ACP-synthase-I	gnl\|CDD\|181184	PRK07967, PRK07967, beta-ketoacyl-ACP synthase I.	0
NC_015947.1\|WP_014035857.1\|532122_532791_+\|phosphoglycolate-phosphatase	gnl\|CDD\|237310	PRK13222, PRK13222, N-acetylmuramic acid 6-phosphate phosphatase MupP.	3.55972e-83
NC_015947.1\|WP_014035858.1\|532877_534719_-\|TonB-dependent-vitamin-B12-receptor	gnl\|CDD\|273802	TIGR01779, Vitamin_B12_transporter_BtuB, TonB-dependent vitamin B12 receptor. This model represents the TonB-dependent outer membrane receptor found in gamma proteobacteria responsible for translocating the cobalt-containing vitamin B12 (cobalamin). [Transport and binding proteins, Other, Transport and binding proteins, Porins].	0
NC_015947.1\|WP_042358473.1\|519794_521783_+\|PAS-domain-S-box-protein	gnl\|CDD\|236842	PRK11091, PRK11091, aerobic respiration control sensor protein ArcB; Provisional.	1.47901e-63
NC_015947.1\|WP_014035853.1\|528578_529490_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293825	cd07739, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) from which this fold was named are only a small fraction of the activities which are included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	5.95011e-98
NC_015947.1\|WP_014035845.1\|521826_522117_+\|DUF3247-family-protein	gnl\|CDD\|371627	pfam11607, DUF3247, Protein of unknown function (DUF3247). This family of proteins is the protein product of the gene XC5848 from Xanthomonas campestris. The protein has no known function however its structure has been determined. The protein adopts a Lsm fold however differences with the fold were observed at the N-terminal and internal regions.	8.54877e-23
NC_015947.1\|WP_014035851.1\|526465_526981_-\|3-hydroxyacyl-[acyl-carrier-protein]-dehydratase-FabA	gnl\|CDD\|179953	PRK05174, PRK05174, bifunctional 3-hydroxydecanoyl-ACP dehydratase/trans-2-decenoyl-ACP isomerase.	1.46551e-120
NC_015947.1\|WP_014035842.1\|517793_518861_+\|alanine-racemase	gnl\|CDD\|143500	cd06827, PLPDE_III_AR_proteobact, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases. This subfamily is composed mainly of proteobacterial alanine racemases (EC 5.1.1.1), fold type III PLP-dependent enzymes that catalyze the interconversion between L- and D-alanine, which is an essential component of the peptidoglycan layer of bacterial cell walls. hese proteins are similar to other bacterial ARs and are fold type III PLP-dependent enzymes containing contains an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain. They exist as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. Homodimer formation and the presence of the PLP cofactor are required for catalytic activity.	0

>NC_015947.1|WP_014035849.1|524460_525144_+|HAD-family-phosphatase
MTTIAALPFLPDAVIFDMDGLMIDSERVSLACWSEAADEFGLGLDEAVFLRMVGLGDRDTHALLRAQGIEDSVIDAVAARCHELYEARTQTGLPLRPGILELLELLKAHAVPRAVATTTRQPRANRKLAAAGLLPYFDAVITSGDVARPKPAPDIYLLAAQRLGQVPERCLALEDSPAGTRAALAAGMTVIQVPDLVHPDEELRALGHRIVGSLVDAHALLLPLLPK
>NC_015947.1|WP_014035848.1|523762_524464_+|pseudouridine-synthase
MKLVKHIANLGYGSRKQVQWMFREGRVTDADGEVLYADDQVPHEAIRVDGEPLDPPVGLSIALHKPVGYTCSTKDTGRLIYDLLPPRFRDRDPVLSTVGRLDRETSGLLLLTDDGGLLHRIISPKSKLPKVYEVELSDDLRGDEVALFASGTLMLESEKTPLLPAELEVLEARRARLVLHEGRYHQVRRMFAATGNHVQALHRSRVGGLDLQGLDEGQWRQLTSTDLDTLFAP
>NC_015947.1|WP_014035847.1|522701_523766_+|methyltransferase
MASSDDAPLQTLLLPFSQGALRWPEGPVAFLRARDGWPLREAAGNREVHCEQSFAPFAQPLQQAAGWTVSGQLDDVAGKGRYPLVLVLPPRQREEARALFARALALVAEGGRIVACQSNNEGARSGEGDLKQLTGLGGCLTKNHCRVYWTAPLQGQHDADLAKRWSALDAVRPIMGGRFLSRPGVFAWDRIDPASALLAEHLPADLAGRAADLGAGYGYLSRELLERCPRITALDLYEAEQRALALAELNLAPPPRALPLRFLWQDVTAGIEPGYDVIISNPPFHTPSRADRPDIGQRFIAVAAQALRPGGRLYVVANRHLPYEHTLNDSFGAVRVVAERDGFKLVEAVKGKGK
>NC_015947.1|WP_014035846.1|522279_522543_-|hypothetical-protein
MRALFVGGVVDNSEMDLEGSHPPVHYPEDTGGGHSRYRLHQVGHGADGSVAYAVYGAPDLADDEVARVADERAYARRFEATPTLFEH
>NC_015947.1|WP_014035845.1|521826_522117_+|DUF3247-family-protein
MSRIAPRIHTDPAQIARLEGLLPQLEGETQVELTLHDGRRLLGTVAVRPTVQQYRNEAGDEGSNGQLRLDDYDTPVQQHHVWLDEIASIRRLPPRV
>NC_015947.1|WP_042358473.1|519794_521783_+|PAS-domain-S-box-protein
MMVPAPEPDLHHGVLERINAGFCVIQVLFEGDRAVDYRFIEVNDAFERHTGLKDARGQRMSLLEPHHEEDWFRIYGEVARSGRPAQFEMEARALGRSFSVDAVRVGRPGEDKVGILFFDITARKQMEVELGESEARFSALADGLPMPVWVLDERGHARFVNSAFSEFFGGDETRVPEDVWRGLVHPDDASVFEYELQEALKAQRSMHALVRARRADGQWRWLEMNARPRFSRMGRFIGLAGSSPDVTERREIELAREELLQSERAARSAAENMARLKDEFLATLSHELRTPLTTILGWSELLLQRVDNTSPLYKGLNVIANSAGAQKRLISDMLDLSSMLLGKVQLEVEVLDLSTLLGEAIGAQELVAEGKALDVHLQLPEQPSLVLGDATRLQQVFWNLLSNAIKFTPAEGRIDLQLRADGNHWEITVRDTGDGIAPEFLNHLFSRFRQADGTTTRRHGGLGLGLAIVQQLVELHGGTVAAASEGHGHGATFTVRLPQHIPDAERRPLREVISGPILEPVIVEPYPLRGMHVLAVEDQPEVLEYLRRMLEEQGASVSAASSAGEALALLADTGHLQYHVMLTDIGMPGMDGYGLVRTLREDMGVDATTLPAVAVTALARADDRRRALASGFQEHVAKPYSVAQLVAAVRKVQVPRADSALH
>NC_015947.1|WP_014035843.1|518983_519550_-|DUF3016-domain-containing-protein
MNRSLATALLLAGALMAGSANAAPRAVTDPDAPRALQANGPVSVKWDDPAKFTEIRQSTNRFEAERGNWVQQLASYVQTMAAKPLQPGQTLDVTLVDIKRAGDYEPWHGPRGSDIRIMRDIYPPRITLQYTLKDASGRIVDEGEAKLSDTGYLHNLGLKSDSDPLRYEKRLIDDWVKRQLTTQATAAR
>NC_015947.1|WP_014035842.1|517793_518861_+|alanine-racemase
MRPARALIDLGALRSNYRLARELGGGKALAIIKADAYGHGAVRCAQALEGEADGFGVATIEEALELRQAGIRAPILLLEGIFEPSDMALVAEHDFWFAVGSPWQLEALVAFDSPRPLTVWLKLDSGMHRLGLDVDSFRAAHARLSALPQVERIVLMTHLARADELDSERTHEQAATFARAIDGLHGETSVCNSPALLGWPDVRSDWVRPGLMLYGANPLPDNTALTERLRPVMTMQSKVIAERWIEAGEPVGYGARFVAKARTRVGVVALGYADGYPQFAPNGTPVLIDGQPGALIGRVSMDMLTVDLTAHAQAGIGSVVELWGSAPTLSELAPRCGVSAYQLPCAVKRVAKVYV
>NC_015947.1|WP_014035841.1|516510_517815_+|D-amino-acid-dehydrogenase
MRVLVLGSGVIGTTSAWYLRQAGFEVTVIDRQPGPALETSFANAGQLSFGYTSPWAAPGVPKKAIGWLFEKHAPLAIKPGMDLAQYRWLWQMLRNCTHERYAINKARMVRMSEYSRDCLNELRAQIGIEFEGRDLGTTQLFRTQQQLDASAQDIEILAQYGVPYEVLDRAGIIQAEPALAHVDGLVGALRLPRDQTGDCQLFTRRLAQMCVDAGVEFRFDQDITGLEFDGDRITGVRIDGKLETADRFVVALGSYSPALVAPLGMRLPVYPLKGYSLTLPITDPAMAPTSTILDESYKVAVTRFDDRIRVGGMAEVAGFDLSLSQRRRETLELVVSDLYPKGGDLSRAQFWTGLRPATPDGTPVIGATPFRNLYLNTGHGTLGWTMACGSGRYLADLMSARQPQISTEGLDIFRYGQYGHAPQHENRTCVLPAR
>NC_015947.1|WP_004140558.1|515881_516361_-|AsnC-family-transcriptional-regulator
MATRTRELDKIDRKILRILQAEGRISFTELGERVGLSTTPCTERVRRLEREAVITGYHAHLDPAAVKASLLVFVEISLAYKSGDIFEEFRRAALKLPNVLECHLVSGDFDYLLKARISEMASYRKLLGSTLLTLPHVRESKSYIVMEEVKETLSLPIPD
>NC_015947.1|WP_014035850.1|525257_526466_-|beta-ketoacyl-ACP-synthase-I
MRRVVITGMGITSCLGNDLDTVSAALREGRSGITLLADHADAGLRSQVGGRVDLDLDALIDRKQKRFMSDAAAFAYLSMRDAIADAGLSPEQVSNLRTGLIAGSGGGSSEWQIGAVDLLRERGVRKVGPYMVPRTMCSTVSACLATAYQIKGVSYSLSAACATSAHCIGAAADMIRHGAQDIMFAGGGEDLHWSMSVMFDAMGALSTSFNETPASASRPYDKDRDGFVIAGGGGMLVLEDYDHAVARGAHIHAELIGYGVTSDGADMVAPSGEGAVRCMKMALQGVDRPLDYLNTHGTSTPLGDVTELNAIREVFGDAVPPLSSTKALSGHSLGAASVHEAIYCLLMMRDGFVAGSANIGELDPKVVDFPILRESREQQLDTVMSNSFGFGGTNAALVFGRV
>NC_015947.1|WP_014035851.1|526465_526981_-|3-hydroxyacyl-[acyl-carrier-protein]-dehydratase-FabA
MTRLHAFNREQLLASARGELFGTAAGRLPNDPMLMFDRITDIHEDGGPHGKGMVRAELDIRPDLWFFGCHFIGDPVMPGCLGLDAMWQLTGFFLTWLGAPGKGRALGCGEVKFTGQVLPDAKLVRYEIDISRVINRKLVMAQSDARMYVDDREIYSARDLRVGLFTETGSF
>NC_015947.1|WP_014035852.1|527171_528266_+|DNA-polymerase-IV
MTRLRKIIHVDMDAFYASVEQRDDPSLRGKPVVVAWRGARSVVCAASYEARVFGVRSAMPAVRAERLCPDAIFVPPDFARYKAVSQQVREIFLRHTDLVEPLSLDEAYLDVTEPKSGIELATDIARTIRTQIREETRLTASAGIAPNKFLAKIASDWRKPDGQFVIPPQRVDAFLLSLPVNRVPGVGKVMEGKLAARGIVTCGDLRQWALIDLEEAFGSFGRSLYNRARGIDERPVEPDQQVQSISSEDTFAEDLPLEDLGEAIVQLAEKTWNATRKTERVGHTVVLKLKTAQFRILTRSFTPERPPESMEELRDIALALRARVDLPAETRYRLVGVGLGGFREKEPVVQGELFEHGPNESASI
>NC_015947.1|WP_014035853.1|528578_529490_-|MBL-fold-metallo-hydrolase
MRTAALLLPLALAATFTSAPLLAAPATAAPATATKSQLHLQTFHPGPQAMFSVSSVLIEGRHDAILVNAQFGASDARKLVELIRASGKQLTTIYISHGDPDYYFGLATLQDAFPQARIVATAQTVAHIQQTQAGKLAYWGPKMGADVPARIVVPQVLDGDALQLEGQRLPLIGLDGPTPDRTVLWVPSLRAIVGGIPVVAGEHVWMADTQTPKSHADWLQTLQRLQALKPKVVVPGHYAPGAALDASALRFTADYIRAFDAETAKAKDSAALVKAMQARYPKLDGVASLELSAKVAKGEMQWP
>NC_015947.1|WP_014035854.1|529581_530220_-|NAD(P)H-binding-protein
MKIALVGSTGNIGRQIARHALARGHELTVIVRSAQDLPAELAGAHPVIASLDDQDALVAAIAGHDVLASAYGPRPGDDIGRVGEVAAQLAAAARKAGVPRLVVVGGAGSLEVAPGVQLVDTPTFPDAYKPYALAHREAFNRLQAVDDLDWTFFSPAAEIGPGEERGQYRVQPKAFLADASGHSRISYADYGAAFVAELEAHAYPKQIITAAY
>NC_015947.1|WP_014035855.1|530328_531258_+|LysR-family-transcriptional-regulator
MDRLTAMTVFVEVAERGSLTAAAEVLDMSRAMVSRYLAEVESWLGARLLHRTTRRVSLTGPGEAALARFRQMLAIGEELQGELASDDPEPHGTLRVTASVSFGQSHLARAVAGFVARHPAARIELLLVDRTVNLVEERVDLAVRIARQIDPSLIARRLATCRSVLCATPSYLQARGTPTAPEHLAAHNCLTHHYVGKSLWQLHRDGRSLSVAVGGNISANEASLLLEAVRAGAGIAMLPTYQVAPLLRSGELIELLPGFSLDELGIHAVYASRRQQPAIMRRFLDYLAECFASPAFQDLDWRPPGKENT
>NC_015947.1|WP_014035856.1|531254_532046_+|class-I-SAM-dependent-methyltransferase
MNHGQALIDHNRAAWDRQASEVREWSRPVESSTIAAAREGRWQVHLTPRALPLDWLGDVRGRRILCLASGGGQQAPVLAAAGADVTVFDLSDGQLEQDRRVAARDGLQLRTVQGDMRDLHVFANDSFDVVFHPISNLYVPDVRPVWTECRRVLARDGMLMASFYNPVLFVGARDPQLDAQGLIRPQYAIPYSDLEDLAPAEREAKLARGDALTFGHSLTELIGGQLDAGFVIDRFMEDWQPQPRFLIDRYLPTFLATRARRIG
>NC_015947.1|WP_014035857.1|532122_532791_+|phosphoglycolate-phosphatase
MSYPYPLVVFDLDGTLVDSAADIAEALNRTLEDIGVARVPEATVLGWIGDGVRRLVEQAVHAAGREVDLAEVMPVFMVHYRECLLRSPRLFDGVAEALAQLRARAVPLAICTNKPEALVPPLLQHLGIGDAFALVLGGDSLPQRKPSGEPLRHIAAHFGLPIDACLMVGDSLTDYRAAEDAGMPIALVRYGYPRGLDLATAHAVAVIDDLRELPGLAAGVRV
>NC_015947.1|WP_014035858.1|532877_534719_-|TonB-dependent-vitamin-B12-receptor
MKLQSRMLSLAVLAALPALAQAADDTTALDQVLVTATRTPIALQDSIAPAQVIDRAQIESSQATSLQELLRGRAGINLTNAGGLGKQSSLFLRGTNSGHTVVLVDGVRINSADLGLAMYQDLPLAQIERVEIVRGPQSSLYGADAIGGVIQIFTRRNQGDFAPHFQLGGGSNGLREASGGIGGGTERGWFGADIAYQHSDGIDACRGSATLFTGCFADEPDRDGYRNLSKSLRGGYTFNDQWNVEGSALRADGKNHYDGYYNYSETRQQVLAGKVRYTPSERLAFTANVGRSDNESDNFGDFGARGSAQTHRDSASLQGDFTLAEGQLLSTGVDWSEDNLDGSSAGYLVDSRRNTGVFVQYQGRFGRHQLQASARNDDNQQFGNHATGSLGWAMQLDHGLRVNASYGTAFKAPTFSDLYDPWSGVPTLKPEKSKSANLGVSQQGQGWHWGLDVYETRIDDLITYDASTMKMQQVEKARIRGAELTGGVLLAGFDINAQLSYTDPRNRTHGSTQFDNWLPRRAQQTARLDVDRRFGDFRAGLTVQGAGKRYDDAANAVKVGGYGTLDLRAEYALTPEWSLLARAANVFDRRYETVAWFNQPGREYQLSVRYQPK
>NC_015947.1|WP_014035859.1|535199_535778_+|histidine-phosphatase-family-protein
MILDLVRHAGNGRDEFLDGRSDPPQLARLPQELVDAYAAQPWERVISSPRLRSLHTAMALATPRGLDVEADEEWEELDFGDWDGQSLFDLPEDAMAAFHADPHAFPPPNGESWGHFERRIARALDRLLDDDDPVPTLVVSHGGPLRMVLSQVCGLPMSLCWALRIDHGTRLRVWLERGEVGLVGELLELQQP

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Crispr_ID: NC_015947_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015947_4

674210-674314

Orphan

Consensus_repeat	Method
GGTGGGTGCCAACCTTGGTTGGCAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015947_4

>merge|NC_015947|4|674210-674314|CRISPRCasFinder
GGTGGGTGCCAACCTTGGTTGGCACCGATGGCACATCCACTGGTGGGTACCAACTGTTGGTTGGCACAGATGACTGCTTCGGTGGGTGCCAACCGTTGGTTGGCA

>NC_015947|4|4|674210-674314|CRISPRCasFinder
GGTGGGTGCCAACCTTGGTTGGCAC	CGATGGCACATCCACTGGTGGGTACCAACTGTTGGTTGGCACAGATGACTGCTTC
GGTGGGTGCCAACCGTTGGTTGGCA

Protein	Signature genes	Signature genes Name	Protein_function
NC_015947.1\|WP_014035951.1\|661152_663300_+\|glycosyl-transferase-family-protein	unknown	unknown	gnl\|CDD\|237974
NC_015947.1\|WP_014035952.1\|663296_666131_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372547
NC_015947.1\|WP_014035962.1\|677667_678288_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|275096
NC_015947.1\|WP_014035961.1\|676635_677520_-\|hypothetical-protein	unknown	unknown	unknown
NC_015947.1\|WP_014035957.1\|673096_673525_+\|hypothetical-protein	unknown	unknown	unknown
NC_015947.1\|WP_014035963.1\|678813_679440_+\|riboflavin-synthase	unknown	unknown	gnl\|CDD\|236455
NC_015947.1\|WP_014035955.1\|670610_671075_+\|RcnB-family-protein	unknown	unknown	gnl\|CDD\|378715
NC_015947.1\|WP_014035960.1\|675995_676634_-\|hypothetical-protein	unknown	unknown	unknown
NC_015947.1\|WP_014035965.1\|680732_681200_+\|6,7-dimethyl-8-ribityllumazine-synthase	unknown	unknown	gnl\|CDD\|234606
NC_015947.1\|WP_014035959.1\|675476_675872_-\|hypothetical-protein	unknown	unknown	unknown
NC_015947.1\|WP_014035966.1\|681796_682759_+\|thiamine-phosphate-kinase	unknown	unknown	gnl\|CDD\|235583
NC_015947.1\|WP_005408048.1\|667211_668528_-\|NCS2-family-permease	unknown	unknown	gnl\|CDD\|225161
NC_015947.1\|WP_014035956.1\|672639_673104_+\|hypothetical-protein	unknown	unknown	unknown
NC_015947.1\|WP_014035954.1\|668692_670357_-\|energy-dependent-translational-throttle-protein-EttA	unknown	unknown	gnl\|CDD\|236992
NC_015947.1\|WP_010481984.1\|673674_674196_+\|transcriptional-repressor-NrdR	unknown	unknown	gnl\|CDD\|234774
NC_015947.1\|WP_014035958.1\|674355_675441_+\|bifunctional-diaminohydroxyphosphoribosylaminopyrimidine-deaminase/5-amino-6-(5-phosphoribosylamino)uracil-reductase-RibD	unknown	unknown	gnl\|CDD\|182729
NC_015947.1\|WP_010481990.1\|671261_672515_+\|serine-hydroxymethyltransferase	unknown	unknown	gnl\|CDD\|234571
NC_015947.1\|WP_005408062.1\|681196_681676_+\|transcription-antitermination-factor-NusB	unknown	unknown	gnl\|CDD\|234686
NC_015947.1\|WP_014035964.1\|679436_680537_+\|3,4-dihydroxy-2-butanone-4-phosphate-synthase	unknown	unknown	gnl\|CDD\|237587
NC_015947.1\|WP_042359084.1\|666124_667090_-\|DUF4434-domain-containing-protein	unknown	unknown	gnl\|CDD\|373094

Protein	Function_ID	Function_description	E-value
NC_015947.1\|WP_014035951.1\|661152_663300_+\|glycosyl-transferase-family-protein	gnl\|CDD\|237974	PRK15489, nfrB, glycosyl transferase family protein.	0
NC_015947.1\|WP_014035952.1\|663296_666131_+\|hypothetical-protein	gnl\|CDD\|372547	pfam13283, NfrA_C, Bacteriophage N adsorption protein A C-term. The function of this domain is unknown but it is found at the C-terminus of bacteriophage N4 adsorption protein A, in association with an N-terminal region of TPR repeats.	1.24458e-24
NC_015947.1\|WP_014035962.1\|677667_678288_-\|hypothetical-protein	gnl\|CDD\|275096	TIGR04273, activator_of_XA21-mediated_immunity_Ax21, sulfation-dependent quorum factor, Ax21 family. This family consists of proteins closely related to Ax21 (Activator of XA21-mediated immunity), a protein that is secreted by a type I secretion system (RaxABC), and that appears to be sulfated on an N-terminal region tryosine in a motif LSYN. Ax21 acts in a quorum-sensing system. Homologous peptide-mediated quorum-sensing systems appear to exist in other species, such as the emerging opportunistic pathogen Stenotrophomonas maltophilia. Intriguingly, the rice genome encodes a receptor (XA21) for this protein that triggers innate immunity. [Cellular processes, Pathogenesis].	5.55322e-20
NC_015947.1\|WP_014035958.1\|674355_675441_+\|bifunctional-diaminohydroxyphosphoribosylaminopyrimidine-deaminase/5-amino-6-(5-phosphoribosylamino)uracil-reductase-RibD	gnl\|CDD\|182729	PRK10786, ribD, bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD.	5.05729e-134
NC_015947.1\|WP_014035963.1\|678813_679440_+\|riboflavin-synthase	gnl\|CDD\|236455	PRK09289, PRK09289, riboflavin synthase.	1.75391e-105
NC_015947.1\|WP_014035955.1\|670610_671075_+\|RcnB-family-protein	gnl\|CDD\|378715	pfam11776, RcnB, Nickel/cobalt transporter regulator. RcnB is a family of Proteobacteria proteins. RcnB is required for maintaining metal ion homeostasis, in conjunction with the efflux pump RcnA, family NicO, pfam03824.	4.13824e-10
NC_015947.1\|WP_014035965.1\|680732_681200_+\|6,7-dimethyl-8-ribityllumazine-synthase	gnl\|CDD\|234606	PRK00061, ribH, 6,7-dimethyl-8-ribityllumazine synthase; Provisional.	4.64826e-66
NC_015947.1\|WP_014035966.1\|681796_682759_+\|thiamine-phosphate-kinase	gnl\|CDD\|235583	PRK05731, PRK05731, thiamine monophosphate kinase; Provisional.	3.31997e-138
NC_015947.1\|WP_005408048.1\|667211_668528_-\|NCS2-family-permease	gnl\|CDD\|225161	COG2252, COG2252, Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism].	1.31235e-168
NC_015947.1\|WP_014035954.1\|668692_670357_-\|energy-dependent-translational-throttle-protein-EttA	gnl\|CDD\|236992	PRK11819, PRK11819, putative ABC transporter ATP-binding protein; Reviewed.	0
NC_015947.1\|WP_010481984.1\|673674_674196_+\|transcriptional-repressor-NrdR	gnl\|CDD\|234774	PRK00464, nrdR, transcriptional repressor NrdR.	3.42163e-86
NC_015947.1\|WP_014035964.1\|679436_680537_+\|3,4-dihydroxy-2-butanone-4-phosphate-synthase	gnl\|CDD\|237587	PRK14019, PRK14019, bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II.	0
NC_015947.1\|WP_010481990.1\|671261_672515_+\|serine-hydroxymethyltransferase	gnl\|CDD\|234571	PRK00011, glyA, serine hydroxymethyltransferase; Reviewed.	0
NC_015947.1\|WP_005408062.1\|681196_681676_+\|transcription-antitermination-factor-NusB	gnl\|CDD\|234686	PRK00202, nusB, transcription antitermination factor NusB.	1.82996e-58
NC_015947.1\|WP_042359084.1\|666124_667090_-\|DUF4434-domain-containing-protein	gnl\|CDD\|373094	pfam14488, DUF4434, Domain of unknown function (DUF4434).	5.13523e-24

>NC_015947.1|WP_010481984.1|673674_674196_+|transcriptional-repressor-NrdR
MHCPFCQHADTRVIDSRVSEDGATIRRRRECEACGERFSTLETVELKLPAIVKSDGTREAFDQRKVRAGFDRALQKRAVAEDKIEAAVRAVVHQLRISGEREVPSIKVGEFVMNELRKLDHVGYVRFASVYRSFEDVADFREEIEKLERDLPSSTEQLQLLGDVIALTKKKKG
>NC_015947.1|WP_014035957.1|673096_673525_+|hypothetical-protein
MDEAVHKRRVGLSLLLGIPIIAAAGTLAVLGLVVAPDYLTAIELLWAGAGLIGLLAWGMLAGLFLWRGQAALCAAPWPLWGGLGLGVLAAVGMVAVAVHRVFTDPDLIVLAYLFLGPPLLLPATHLAWLRWAPAASAPPAPG
>NC_015947.1|WP_014035956.1|672639_673104_+|hypothetical-protein
MDERHLKYLYTALAVLFGLPSLFFGGAGACIALVMGVIGLISLDADKLWFAAGMFAWGVSAITGLVAWVALSIFWLRDGARGLRMASRRWWWLLGMGVLAALPLLAMALYYFTELGPSVLSGLFAGPSLWVPAGMLMLLWLRGRRPVQESSHRG
>NC_015947.1|WP_010481990.1|671261_672515_+|serine-hydroxymethyltransferase
MFPRDVRIESYDPELAKAIAAETQRQEDHVELIASENYTSPAVMEAQGSQLTNKYAEGYPGKRYYGGCEYVDIAEQLAIDRLKQLFGADYANVQPHSGSQANQAVYFALLQPGDTILGMSLAHGGHLTHGAKVNASGKLFNAVQYGVNDQGLIDYDEVERLALEHKPKMVVAGFSAYSQVIDWARFRAIADKVGAYLFVDMAHVAGLVAAGVYPSPLEHAHVVTSTTHKTLRGPRGGIIVAKGADEDLVKKLQSIVFPGIQGGPLMHVIAGKAVAFKEALEPGFKAYQQQVVKNAQAMANTLIARGYKIVSGGTQNHLMLVDMIGKDVSGKDAEAALGKAHITVNKNSVPNDPRSPFVTSGLRLGTPAVTTRGYVEQDCVDLANWIADVLDAPNDDAVIARVRDAVSAQCRKYPVYG
>NC_015947.1|WP_014035955.1|670610_671075_+|RcnB-family-protein
MRINRVMAGAVASVLAFGAVAPAFADNDHRRDHDRREWREDRREWRQDRRDWERDRREARRDWHRDHDRYYRPAPPRVVYRPAPPPPRYGSYGWRVGSPYRNYYSGPVYVVNDYPRYHLRRPPYGHHWIRDDRGNMLLVAIATGVIAQYVLSGR
>NC_015947.1|WP_014035954.1|668692_670357_-|energy-dependent-translational-throttle-protein-EttA
MSSQYIYTMNRVSKVVPPKRQIIKDISLSFFPGAKIGLLGLNGAGKSTVLKIMAGVDTDFEGEARPQPGIKVGYLAQEPELDPTKTVREAVEEGVGEVLQAQAALDAVYLAYAEEGADFDALAKEQERLEAILAAGDAHTLENQLDVAADALRLPPWDAIVGKLSGGEKRRVALCRLLLQKPDMLLLDEPTNHLDAESVEWLEQFLARYTGTVVAVTHDRYFLDNAAEWILELDRGRGIPWKGNYTDWLTQKDERLKQEDNQEKARQKAIQKELEWSRQNAKGGRTKGKARLARLEELQSVDYQKRNETNEIFIPPGERLGNAVMEFKNVSKKFGDRLLFDNLNFLVPAGAIVGIIGPNGAGKSTLFKMITGQEKPDTGEIVVGPTVKLSYVDQSRDALEGNHNVFQEIAGGLDILNINGIEIQSRAYIGRFNFKGQDQQKMVGSLSGGERGRLHMAKTLLQGGNVLLLDEPSNDLDIETLRALEDALLEFPGNTFVISHDRWFLDRIATHILAFEGDSHVEFFQGNYREYEEDKRRRMGDDAAPKRLRFKALK
>NC_015947.1|WP_005408048.1|667211_668528_-|NCS2-family-permease
MSLFERLFQLQQHGTTVRTELLAGVTTFLTMSYIVFVNPEILGTTGMDAGAVFVATCLAAALGSAVMALAANFPVGMAPGMGLNAFFAFTVVGAAGLPWQQALGAVFISGLVFLVLSLTGVRAWLVSGIPSSLRSAIVAGIGLFLAIIALQKSGVIVGNEDTLVALGPLNTAPPLLALAGFLLIAVLEARRIRGAILIGILAVTGAGWALGDVQYQGLVSLPPSLAPTFLQLDLPGLLHHDGGAPIAVLLQVVLVFVLVEVFDATGTLYGVVGRAGLLKLPGAQKRFGRALLADSTAIVAGSMLGTSSTTAFAESASGVQVGGRTGLTALVVSALFLAALLFSPLAAMVPSYATAPALLFVAGLMLRELVEVDWSDLTESVPAALCALAMPFTYSIANGLAFGFIAYAALKAGTGRWREVHPAVWLVAVLFTLRYALE
>NC_015947.1|WP_042359084.1|666124_667090_-|DUF4434-domain-containing-protein
MRRRLLRAAVLAPLAGTLATLPGCSLPVQVDGTFLQPWRSHLQWGLADWQRSLKLAHTLGCRQLVLQWTGIVGGNDGDWSLPDSSLQQLFTAASENNLRIRVGLPFQQRWWQAIGADDATLQAFLADSLAQARSWLAQAPWAQQPAFGGWYLPYELEQYHWADPARQQSLAQWLHGLADAARARGGDCAISCYFSRLQTDGNLVTLWQAVLAQAALRPMVQDGVGVAGAGNVQQLQPLLDHFHAHGIGFDAIVELFRELPGSAADGSAFKGETADAARIQRQLAWARDSGAQHVLVYALEPWLTQDTPQAAALRRRWGLPQ
>NC_015947.1|WP_014035952.1|663296_666131_+|hypothetical-protein
MKTTLLSTVIAVALASVATPVLAQADAALPLSGAAYRIAEQAFAAYERGDYPAAYQQSTEAIRLRPDVVRLRLLQIYALQKLGRGAEAQQQARRALDAGLKDPALPALAAATAARSAATGGEGARTTSPSRPVGSAADRSGQQAYALATEAYAAYDAGRMGEAAGKAEQAFRQQPTQGAWALLWVAALEAQQQPEQADAAIATALQLGAPNAEALQARRVTLDRQRALLQAQQAYRSLSTQDDAAAVAQARAAVELAPEVATYRLLLITAQLQQGQLADAERSADQALQADGQDLNARVMRGYLRQRQGNTVLANQDFDTALAAPGSTTQQRNVRLLAVDAALASADRMRAAALLAPLQSALPTDAGDARAQQLLQQAIEQRGRAIRSSRALPRISAQTYPAPFQHCQSGGTGNVCELMPADLQGDGGAAQRAYAAYARQDYAEAIGEARQAVQRAPDDAKLQGLLTTTLASGNRAQQDEARQRLDAALAQRPDDAEALMQRGYLNQKAHEPAQALADFRAAEATGKAPKSVVLDQAYAGAANGDHPQAVSLLRSAIDRADAGELPLDEHQRYNVRNAIANYSREWGVIASAGFRGARQAATNVGGAAISTPGDSVFSTLEAFWRPPAFNDRHGTLELYARLLNTLYDQGGTYESIRAVDPCTGESTPDARARAERLSHSRSTTGWPSTIASFGMRYAFGQTGLSAGIERRQFLGSATRTGDVYPAAAAVQCSLQLALNPPLEASTLARYRLASGSGGWMSYLTYGYYHGTDLRTDVNQWWMVSGYAQGGYTWDDNSAHFTLDALDANGTPVRRIGDANGRLHREQWFAAGELRAGRSFRFGAGQTHWVVTPYVVVGADWLDQRSRVRDIRYPLFPAQSFALNDTQRSWSLGAGPGVGVRYWFREDHYNTPRSYLDLTVQYRFAIGGGDTQRAKGLFATAILYY
>NC_015947.1|WP_014035951.1|661152_663300_+|glycosyl-transferase-family-protein
MDGLFWNIQLANYYAALETTAAAVAVLILISSLDDLFIDVWYWVRESWRALTIKRRDAYRPLTQDDLLQRPEQPLAIMVPAWMEYDVIAQMVENMINVLDYREYVVFVGTYPNDQQTIDEVERMRRRYKRLRRVEVPHDGPTSKADCLNWLILAIFDYEKRHDIEFAGVILHDSEDVLHPMELRFYNYLLPRKDMIQLPVTSLDREWYELVAGVYMDEFAEWHAKDLVVRESVSGMVPSAGVGTCFSRRALLALSAQTDNQPFNTDSLTEDYDVGARLAAMGMQSIFARFPVQFRVRRPSWFGWGPVRERTQQMALCVREYFPDNFRASYRQKARWVLGIGLQSWESLGWRGSLATKYLLARDRKGIITSFVSIIAYLIFLQLLLFWVLKMTGVWTMQFPSVFQAGTWQMNVALLTTAALATRVVQRFYFVNRLYGWEHALMSIPRMVVGNMINFMATARAWKVFLAYLLFGKRMVWDKTMHDFPDAAQLVQTRKQLGELLTTWQAVEPERLQQALAQQHAGRRQPLGRILLTQGWLDDETLAEAIAFQGDLPRAVIDVDYLRACQFPVSADACVQWRMLPLPPRQQGTLRLAVASPLPEEALALLKQETRSEHIEQSIARESEINAGLRLIGGDQHWHLDNVPLLGDLLVEMRLIDHARFEIALDAYKPQRDGRIGDYLVKQGITTEDAVAQAMQEQRRRAAALQSPPPGALPA
>NC_015947.1|WP_014035958.1|674355_675441_+|bifunctional-diaminohydroxyphosphoribosylaminopyrimidine-deaminase/5-amino-6-(5-phosphoribosylamino)uracil-reductase-RibD
MSTPFSVLDHLHMANALRLAERAAYTTRPNPMVGCVIAHGERVVGQGWHQRAGGPHAEVFALREAGGEARGATAYVTLEPCAHYGRTPPCALALIEAGVSRVVAAMRDPFPKVDGGGFDLLRNAGIEVAEGLMAVQARELNKGFLSRVERNRPWVRVKLAASLDGRTAMADGTSKWITGPAAREDVQHWRARAGAILTGADTVLADDPMLTVRLADTEVMPPLRVVLDSRLRSLECSRVREGGAPTLYLHDAAVSAPDAADAEFASVPCVDGRLDLGAVLALLAERGINEVHTEAGATLAGALLRGGWVDELLLYQAPTLLGDNGRPLLAGLGIDAMDQQRRLRVVDQRQVGEDIRLLLRP
>NC_015947.1|WP_014035959.1|675476_675872_-|hypothetical-protein
MKHRTTSTTVMLMALMALTACGQAKVPKSRITTFSVRPAVAFESTLLSDRQLDAWMSEDDDCHAFLMYHDQCAVLVLPHEYDDGFTRHQLRLKAKKLPGEALGAYCRNLHALWKQQWKGQCPVGEEDDEDA
>NC_015947.1|WP_014035960.1|675995_676634_-|hypothetical-protein
MVALKPLGLAALLLAPGSALAGTGAASPARLFDLHAQVIVHGDARAQAALAAQLGTDDAPAFVAALAAASQLDEAPELAGWPAAAQALRTRQASAQCKADGVRWPKGHDGDVAEVAYHCRLPDLSGLLPLYRQHPVPFTGPHPPQMSVPLAAAYTAAMRNAPDRVRSGTLIFQRSGDHRAWRMRDPGPLMALVAGAFLPFFEWNEHLPDDSG
>NC_015947.1|WP_014035961.1|676635_677520_-|hypothetical-protein
MKTPLRTLLASALLAAPLLAGAAPATLTPEQAFDLYARVLLEDDAAATRTLNDALKPAFDGQDAVTPNPGALAKALAEPWQVVLASTGAKADAAASEALYAKALRDSKCRASKSVIEDNEYVEDQKLARITFSCQVPDLGKVRPLFAASLASDASPASRKQFTDAYTQALQSGARVPVSGTFTLYPAKDNGYWYSGNFDDLVGTVTGALAPFEDWMQDAQAANAPKVTGVPGCDLLLQQHRACVAKIAPDQISGVDAMAEELKAKAQVQSADEMTQECKALRPIAEMMWTNECA
>NC_015947.1|WP_014035962.1|677667_678288_-|hypothetical-protein
MRKILIVAALLAAAPFSASADALSYTYVEGGWTQVQVDDNALDDPKVDGGYLRGSVALAEQVYVFGGWSRTSKTRHYGEDSLKLELNQPELGIGYHMPWTDRLDFTADAAWVRQNAESTLRYDGVRYHGKDHTNLGRVTMGIRGKPSRMTEAWAKAGYMDGGNNYKGTWVGTVGGQINFTKTWGVVGEIAGYRDVTQYSVGVRASF
>NC_015947.1|WP_014035963.1|678813_679440_+|riboflavin-synthase
MFTGIIEGVGRLAARESIGGDVRFTFNVGNLPFDNVQMGESIAINGVCLTVIAFDASSFQADASTETLGLTTLGQLGEGAVINLERAMRPTDRLGGHLVSGHVDGLGQVLSIHEDARAQRWRFAAPASLRRYIAKKGSICVDGVSLTVNEVDDEGFEVALIPHTVANTAFSASGVGSAVNLEIDLVARYVERLIGVPTNGQHPHGDAA
>NC_015947.1|WP_014035964.1|679436_680537_+|3,4-dihydroxy-2-butanone-4-phosphate-synthase
MNFAPIPEILEDICLGRMVVIVDDEDRENEGDLIMAAELVKPSDINFMVTHGRGLVCLPLTRTRAADLGLAPMVQANTAQFQTNFTVSIEAAEGVTTGISAHDRAHTIRTAVKPNAKPSDLHQPGHIFPLIAQPGGVLTRAGHTEAGVDLAMLAGLEPAGVLVEILNPDGSMARRPELEVFAREHGLKMGSIADLIAYRLATEKTVERVDEREIDTEFGPFKLVTYRDRIAHDLHFALVRGNPDAETPTLVRVQVENPLADLLHWRRDDFGVAATDALRAIDAEGAGVMVVLSAPRDGEALLARLRQQPAPVVPGKDKDVGQWRRNGAGAQILSDLGLGKLRVLGTPRRQIGLAGYGLEVVETVTL
>NC_015947.1|WP_014035965.1|680732_681200_+|6,7-dimethyl-8-ribityllumazine-synthase
MSHYEGDLRTPESARFAILASRWNARITDALVAGARLSLAGNGITEANIDVIRVPGAWELPLVAARLAAAHEHAAILTLGCVIRGDTRHYEHVADRCAEGLMRVQLDFGVPVLNGVLAVEHAEDAEARAGGSHGNKGEEVALAALEMVNLLEQLP
>NC_015947.1|WP_005408062.1|681196_681676_+|transcription-antitermination-factor-NusB
MNKNTQGKPSGKPVRRDGVDPVLRSRARRRAVQAIYAWQISGGNAQSLIAQFAHEQAREIADLAYFEALLHGVLDNRRDIDEALGPYLDRGIEEVDAIERAVLRLAAYELRYRLDVPYRVVINEAIESAKRFGSEHGHTYVNGVLDRAAVEWRKVESGH
>NC_015947.1|WP_014035966.1|681796_682759_+|thiamine-phosphate-kinase
MSLAEFALIDRIRARTLERDDILLGIGDDAALLQPRANEQLVVTADTLNSGVHFPVETPAFDIGWKTLAVNLSDLAAMGARPAWCTLALSLPEASEDWIEAFADGFFALADQHDIALIGGDTTRGPLSLSVTAMGQVGRGQALRRDRAQVGDDIWVSGTLGDAAGALRLWQQGALSIATATLLADYESLRLRLLRPTPRVTLGLRLRAFAHAAVDVSDGLLADLGHIATRSNVAAHVDADSLPISHALRELLGREGARDCALRGGDDYELCFTAAADQRDALHYLAESLDVPLTRIGRIAEGQGVHVDGEAADGGYQHFA

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Crispr_ID: NC_015947_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015947_5

730265-730360

Orphan

Consensus_repeat	Method
TGCCATCCACGCGTGGCGTGGATCTAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015947_5

>merge|NC_015947|5|730265-730360|CRISPRCasFinder
TGCCATCCACGCGTGGCGTGGATCTACGTGTGGCATTGCGGCTGATGAAGGGGCGGTTCCGCGTGGTCATGCCATCCACGCATGGCGTGGATCTAC

>NC_015947|5|5|730265-730360|CRISPRCasFinder
TGCCATCCACGCGTGGCGTGGATCTAC	GTGTGGCATTGCGGCTGATGAAGGGGCGGTTCCGCGTGGTCA
TGCCATCCACGCATGGCGTGGATCTAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015947.1\|WP_014036007.1\|741053_742769_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|153248
NC_015947.1\|WP_014036002.1\|730886_731360_-\|Cys-tRNA(Pro)-deacylase	unknown	unknown	gnl\|CDD\|237976
NC_015947.1\|WP_014036004.1\|733373_735890_+\|prolyl-oligopeptidase-family-serine-peptidase	unknown	unknown	gnl\|CDD\|224423
NC_015947.1\|WP_014036005.1\|736062_738774_+\|phosphoenolpyruvate-carboxylase	unknown	unknown	gnl\|CDD\|234570
NC_015947.1\|WP_014035993.1\|722937_723522_-\|DUF4124-domain-containing-protein	unknown	unknown	gnl\|CDD\|379230
NC_015947.1\|WP_014035994.1\|723562_724390_-\|methylenetetrahydrofolate-reductase-[NAD(P)H]	unknown	unknown	gnl\|CDD\|273212
NC_015947.1\|WP_014035992.1\|721914_722868_+\|Nudix-family-hydrolase	unknown	unknown	gnl\|CDD\|236361
NC_015947.1\|WP_014035997.1\|726601_727333_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225818
NC_015947.1\|WP_014036008.1\|742765_743566_+\|UDP-2,3-diacylglucosamine-diphosphatase	unknown	unknown	gnl\|CDD\|277343
NC_015947.1\|WP_014035995.1\|724592_725519_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NC_015947.1\|WP_014035999.1\|728993_729551_+\|DUF3228-family-protein	unknown	unknown	gnl\|CDD\|371591
NC_015947.1\|WP_014036000.1\|729627_730263_+\|energy-transducer-TonB	unknown	unknown	gnl\|CDD\|367555
NC_015947.1\|WP_014036006.1\|738861_739368_-\|acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|224523
NC_015947.1\|WP_014035998.1\|727339_728857_-\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|238624
NC_015947.1\|WP_010481882.1\|739506_740718_-\|methionine-adenosyltransferase	unknown	unknown	gnl\|CDD\|235374
NC_015947.1\|WP_014036003.1\|731687_733133_-\|adenosylhomocysteinase	unknown	unknown	gnl\|CDD\|377487
NC_015947.1\|WP_014036009.1\|743770_744829_+\|metal-dependent-hydrolase	unknown	unknown	gnl\|CDD\|377294
NC_015947.1\|WP_014035996.1\|725555_726605_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|225814
NC_015947.1\|WP_014035991.1\|719068_721801_+\|preprotein-translocase-subunit-SecA	unknown	unknown	gnl\|CDD\|237259
NC_015947.1\|WP_014036001.1\|730401_730887_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_015947.1\|WP_014036007.1\|741053_742769_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|153248	cd07986, LPLAT_ACT14924-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Pectobacterium carotovorum subsp. carotovorum PC1 locus ACT14924 putative acyltransferase, and similar proteins.	4.88545e-58
NC_015947.1\|WP_014036002.1\|730886_731360_-\|Cys-tRNA(Pro)-deacylase	gnl\|CDD\|237976	cd00002, YbaK_deacylase, This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS) inserted (INS) editing domain. The bacterial amino acid trans-editing enzyme YbaK is a deacylase that hydrolyzes cysteinyl-tRNA(Pro)'s mischarged by prolyl-tRNA synthetase. YbaK also hydrolyzes glycyl-tRNA's, alanyl-tRNA's, seryl-tRNA's, and prolyl-tRNA's. YbaK is homologous to the INS domain of prolyl-tRNA synthetase (ProRS) as well as the trans-editing enzyme ProX of Aeropyrum pernix which hydrolyzes alanyl-tRNA's and glycyl-tRNA's.	5.55434e-75
NC_015947.1\|WP_014036004.1\|733373_735890_+\|prolyl-oligopeptidase-family-serine-peptidase	gnl\|CDD\|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	6.11038e-57
NC_015947.1\|WP_014036005.1\|736062_738774_+\|phosphoenolpyruvate-carboxylase	gnl\|CDD\|234570	PRK00009, PRK00009, phosphoenolpyruvate carboxylase; Reviewed.	0
NC_015947.1\|WP_014035993.1\|722937_723522_-\|DUF4124-domain-containing-protein	gnl\|CDD\|379230	pfam13511, DUF4124, Domain of unknown function (DUF4124). This presumed domain is found in a variety of bacterial proteins. It is found associated at the N-terminus associated with other domains such as the SLT domain and glutaredoxin domains in some proteins. The function of this domain is unknown, but it may have an Ig-like fold.	0.000453501
NC_015947.1\|WP_014035994.1\|723562_724390_-\|methylenetetrahydrofolate-reductase-[NAD(P)H]	gnl\|CDD\|273212	TIGR00676, 510-methylenetetrahydrofolate_reductase., 5,10-methylenetetrahydrofolate reductase, prokaryotic form. The enzyme activities methylenetetrahydrofolate reductase (EC 1.5.1.20) and 5,10-methylenetetrahydrofolate reductase (FADH) (EC 1.7.99.5) differ in that 1.5.1.20 (assigned in many eukaryotes) is defined to use NADP+ as an acceptor, while 1.7.99.5 (assigned in many bacteria) is flexible with respect to the acceptor; both convert 5-methyltetrahydrofolate to 5,10-methylenetetrahydrofolate. From a larger set of proteins assigned as 1.5.1.20 and 1.7.99.5, this model describes the subset of proteins found in bacteria, and currently designated 1.7.99.5. This protein is an FAD-containing flavoprotein. [Amino acid biosynthesis, Aspartate family].	9.73197e-142
NC_015947.1\|WP_014035992.1\|721914_722868_+\|Nudix-family-hydrolase	gnl\|CDD\|236361	PRK08999, PRK08999, Nudix family hydrolase.	3.15076e-160
NC_015947.1\|WP_014035997.1\|726601_727333_+\|response-regulator-transcription-factor	gnl\|CDD\|225818	COG3279, LytT, Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms].	1.94975e-49
NC_015947.1\|WP_014036008.1\|742765_743566_+\|UDP-2,3-diacylglucosamine-diphosphatase	gnl\|CDD\|277343	cd07398, MPP_YbbF-LpxH, Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain. YbbF/LpxH is an Escherichia coli UDP-2,3-diacylglucosamine hydrolase thought to catalyze the fourth step of lipid A biosynthesis, in which a precursor UDP-2,3-diacylglucosamine is hydrolyzed to yield 2,3-diacylglucosamine 1-phosphate and UMP. YbbF belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	2.3167e-69
NC_015947.1\|WP_014035995.1\|724592_725519_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.11052e-11
NC_015947.1\|WP_014035999.1\|728993_729551_+\|DUF3228-family-protein	gnl\|CDD\|371591	pfam11539, DUF3228, Protein of unknown function (DUF3228). This family of proteins has no known function.	4.89814e-88
NC_015947.1\|WP_014036000.1\|729627_730263_+\|energy-transducer-TonB	gnl\|CDD\|367555	pfam03544, TonB_C, Gram-negative bacterial TonB protein C-terminal. The TonB_C domain is the well-characterized C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance.	1.3908e-13
NC_015947.1\|WP_014036006.1\|738861_739368_-\|acyl-CoA-thioesterase	gnl\|CDD\|224523	COG1607, COG1607, Acyl-CoA hydrolase [Lipid metabolism].	1.56219e-63
NC_015947.1\|WP_014035998.1\|727339_728857_-\|amidohydrolase-family-protein	gnl\|CDD\|238624	cd01299, Met_dep_hydrolase_A, Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a conserved metal binding site, involving four histidines and one aspartic acid residue. In the common reaction mechanism, the metal ion (or ions) deprotonate a water molecule for a nucleophilic attack on the substrate. The function of this subgroup is unknown.	9.47152e-18
NC_015947.1\|WP_010481882.1\|739506_740718_-\|methionine-adenosyltransferase	gnl\|CDD\|235374	PRK05250, PRK05250, S-adenosylmethionine synthetase; Validated.	0
NC_015947.1\|WP_014036003.1\|731687_733133_-\|adenosylhomocysteinase	gnl\|CDD\|377487	pfam05221, AdoHcyase, S-adenosyl-L-homocysteine hydrolase.	0
NC_015947.1\|WP_014036009.1\|743770_744829_+\|metal-dependent-hydrolase	gnl\|CDD\|377294	pfam04307, YdjM, LexA-binding, inner membrane-associated putative hydrolase. YdjM is a family of putative LexA-binding proteins. Members are predicted to be membrane-bound metal-dependent hydrolases that may be acting as phospholipases. It is a member of the SOS network, that rescues cells from UV and other DNA-damage. Expression of YdjM is regulated by LexA.	5.00857e-26
NC_015947.1\|WP_014035996.1\|725555_726605_+\|sensor-histidine-kinase	gnl\|CDD\|225814	COG3275, LytS, Putative regulator of cell autolysis [Signal transduction mechanisms].	6.4279e-43
NC_015947.1\|WP_014035991.1\|719068_721801_+\|preprotein-translocase-subunit-SecA	gnl\|CDD\|237259	PRK12904, PRK12904, preprotein translocase subunit SecA; Reviewed.	0

>NC_015947.1|WP_014036000.1|729627_730263_+|energy-transducer-TonB
MAIWARMILVLLAGTLPATPVLAAKPSVDVACSPLAAVPALRDAEVTALSMQPEGGRCVVEVKAANDKALLRQQRMLEVLTQYACAGPAEVSVDDTRLSLQLRLPKHCAARGSRDLFAGEGVAWKPARGVSPHYPPEAMQQGLSGRSLLKALIDAQGTVAAVIVETSSGHALLDEAAVDELRGWPFVRAEAESTVPELTIVRVPMRYALVE
>NC_015947.1|WP_014035999.1|728993_729551_+|DUF3228-family-protein
MSIVLTDFARPRLFPRVPRGNTIQDCTAEQFEAHLNAHAPLKVLDGYAPFCKLFVYENWTSTRCLTVPVTEANRHQLRSGYEARNREELPVLVRWFEGVESPRANYLVVILYSAEQLAREGSPIEADWGIVGCIYTAEPEEVPMAPITMMRNALGVEEGGSGVPLDREAYQRSVAFWENNANWRP
>NC_015947.1|WP_014035998.1|727339_728857_-|amidohydrolase-family-protein
MDAARALPRSARRRRWPIALAILLLAPPVLFAAALLWPLSAPPLPEPGNNRVIVNARVVDVERGHVSEPTTVTVRNGTITAIGEVPRDTTMPVLDAGGRWLLPGFWDMHTHALQLSPQLQFPLMLANGITGTRDMMDCPQAADPLIACVADKRRWTAQAIAGQQVAPRFVQIASFYFEDPSLAPEAAAARARTYSARGIDALKVYNRLRADTYQRLATEAQQLRHPLVGHLPKAVPLEDAVQAGQRSFEHAHLFVRHCFDNAAAWRGGTLDSEDPTALAERMVGGYQPALCNEAFGVMQASGAAFVPTHVTREEDARARDPAFVDDPRLAYLDPLSRWAWRDDLQATVARYPGLRGEDALKAYFEHGLALTGAAHRAGVTVLVGTDTGLGGLRYHDELQWLRQAGLSQADVLRAATLQAARHLDLQASHGSVEVGKVADLVLLDGNPLHDTASTRRVHAVLLAGHLYDRPRLDALLAYARAQARSPAVMARLLWGFLTSPVSAEL
>NC_015947.1|WP_014035997.1|726601_727333_+|response-regulator-transcription-factor
MSGMLRVLIVDDARLARQELRTLLSALPWVQCVGEADDVPAAREAITTLAPDLVLLDVQMPSGSGFDVLDGLETVPAVVFVTAYDTYAVRAFQANALDYLVKPVEAPRLLEALERARQREAVAADVPESRGTLGAQDQVFVREGERCWFVAVSEIRRLVVDGNYTRLWFRDQNALLTRSLSALEARLPQDLFFRANRNTLVNLRRIRGVSPSIGDGYDLALDDGSEVEVSRRQARELRERMAL
>NC_015947.1|WP_014035996.1|725555_726605_+|sensor-histidine-kinase
MDATTPSRRFWTLNALAWAGYAMYGLWVGMRIGGGVVFSGIVLITVSVAVSLWLCSGALRSVALRQRWWEGSLGSLVLKLAAGVVVGASVAQAVTAALLLPALALGWVQLPGGHADYQWSSVLVYWMNTALFLLMWTGLWAGLHGLRRARHSELARLRAEAERSALERDALRARLNPHFMFNALNNLRALILEDPERARDMVTRLSRTLRQALAHNRSEQVTLAEELAVVDDYLAIEAVHFEQRLQVRRQIDADATQAQLPAMALQLLVENAIKHGIASRPGGGEVQIRAALDNDVLRLQVDNPLSTGSEPTHGHGVGLAYLRAQLGTRGRFVLQPVGDRMQALLEIPQ
>NC_015947.1|WP_014035995.1|724592_725519_+|alpha/beta-hydrolase
MKIFLALWYAMKALARLAMIGMAMAVLGSGSAHAATGSTAGRVQVEVVGKGRPLLMIPGLNSSAEVWRETCLALKDVQCHLVQLPGFAGAAAADPRPVDFLPAMRGQLLAYLHDQHLGPVVVIGHSLGGLLGLQMAQAEPKAVSALVVVDALPFLPAARDPKATIDSVRPMADQLRKGMLAADAAQWQAQLKAGLPGMTRDPQRQAELGRWGEGSDRQTTADAMHAVMTTDLRDSIALITAPTLVLGSWAGYQPMGGTEDGTRAVFQAQYAKLQGVQIAMSAQGFHFLMWDDPRWLQEQVQRFLAAHP
>NC_015947.1|WP_014035994.1|723562_724390_-|methylenetetrahydrofolate-reductase-[NAD(P)H]
MTAISFEFYPPKTDEQRSQLDRAAARLKDYGPEYVSCTFGAGGSTLSYTSETVRHLNQHHGFDAAPHLSCVGGTRQEIRELLKLYRAIGCRRLVALRGDLPSGMGFPGDMRYAAELIDFIRAEHGDAFHIEVGAYPETHPQASDALADLKHFKAKIDAGADAAITQYFYNPDAYFHFVDAVRRLGVQVPITPGIMPIANFSQLRRFSEQCGAEIPRWISRKMQAYGDDAESVRAFGTEVVAKLCQRLIEGGAPGLHFYTLNLAKPTTSVLKLLHG
>NC_015947.1|WP_014035993.1|722937_723522_-|DUF4124-domain-containing-protein
MKRFSFLLLLLSLCSASSVVHAQSPRLNRCTDAQGQSVYTDRPCDSVGAQSRLPSPAPTGSTLPRDTLGARCPRRLSELVEALRTGIVSNDVNRLSSLYLWGAVSDAGAQRILGQLESLARRPLVDVVPVYPSQGLASSQEEGQSPAAQGSDPEPPAARHPVGLRLEQTLPGSVSRASTVLGLRRQYGCFWITL
>NC_015947.1|WP_014035992.1|721914_722868_+|Nudix-family-hydrolase
MPSPTRSIHVVAAVITDARGRVLLNRRTENRDMAGLWEFPGGKRESGETSEQALVRELREELGIEADVGPWLMDVPQRYPDKHLTLEVSHVRSWKGTPRGREGQAITWVAQDKLGRYSMPPADLPVVAALRQPDRYLITPAPAEDAGGVQHWHDRLQQAVAAGQQRIQLRLPPEHPQRQAMIEQTVRAHRRGVQWLLNRDIALARALGVGVHLGSEQLLALQERPLPEGQLVAASCHDLEQLQAAQRLGCDFAVLGPVQATASHPEAAPLGWEAFAALRAQVSLPIYALGGMAAGHIAEARRHGGQGIAAIRGLWPA
>NC_015947.1|WP_014035991.1|719068_721801_+|preprotein-translocase-subunit-SecA
MINSLLTRVFGSRNERQLRQLNRIVAKINALEPEIEKLSDEQLQAKTPEFKQRIAGGEALDKVLPEAFAVCREAGRRVLGMRHYDVQLIGGMVLHLGKIAEMRTGEGKTLVATLPVYLNALEGKGVHVVTVNDYLARRDAAQMGKLYNWLGLSVGVVYPGMPHSDKREAYAADITYGTNNEFGFDYLRDNMALSKADRYQRGLHYAIVDEVDSILIDEARTPLIISGPADDSPELYIRVNRVVPHLVKQEAEDGEGDFWVDEKGKQVHLSEAGMEHAEQLLVDAGILDGETEGLYAAQNLTVVHHLNAALRAHAIYQRDVDYIVRDGEVVIVDEFTGRTLAGRRWSDGLHQAVEAKEGVPVQRENQTLASITFQNLFRMYKKLSGMTGTADTEAFEFQSIYGLEVVVIPTNRPTIRKDSPDQVFLNRKGKFNAVLADIEECAKRGQPVLVGTTSIETSEMLSEHLSKAGVKHEVLNAKQHDREATIVANAGRPAAVTIATNMAGRGTDIVLGGSLEAEIHALGEDATDEQKAAVKAEWQKRHDAVKAAGGLHIVGTERHESRRIDNQLRGRSGRQGDPGSSRFYLSLEDNLMRIFASDWVQKAMRMMGMKEDDVIEDRLVSRQIEKAQRKVEAHNFDIRKNLLDFDDVNNDQRKVIYAQRDELLDAESVKANVDGIRDDVIFDIVARFVPPNSIDEQWDLRGLEATLESDFGLQMSLTDLVKEHEELDAEAIATKVQERVNQHFAEKEAGLGEETMRALEKHVMLTVLDQSWKEHLARMDYLRQGIYLRGYAQKQPKQEYKKEAFELFSDMLENVKREVVTLLARVRIRSDEEVQALEAAERQQVQARLSQSQFQHQDAGGYSADEEAAQVEAAQQGVATLQRDEPKIGRNDPCPCGSGKKYKHCHGQLS
>NC_015947.1|WP_014036001.1|730401_730887_-|hypothetical-protein
MRWPWSAAPIPRLDDAQADVLLQDLLSRDGTRITDAARTVARLFSAPSLDALAAHAELIEQRCQGVALGGMLISNQAHLKAALRRLHYWRAREGCLCALNPGYPFFDPRRLVEQGQMQLRSVEEAEDGWGDCHIVTCEQCGQHWRAIDREYHYPWWEWIAL
>NC_015947.1|WP_014036002.1|730886_731360_-|Cys-tRNA(Pro)-deacylase
MTPAINLLKREKIAHTVRSYVHDAHAESYGGEAVDKLGLDPAQVFKTLLASTEAHELLVAIVPVAGQLDLKALAEAAGCKKCEMAAADAAQRATGYLVGGISPLGQKKRLRTFLDASAEALPTLHVSAGRRGLEVELAPADLLRLTAGHYAAIGKSR
>NC_015947.1|WP_014036003.1|731687_733133_-|adenosylhomocysteinase
MNAVAKTFSTEGDYKIRDITLADWGRKELDIAEHEMPGLMSIRRKYQAELPLKGVRVTGSLHMTIQTAVLIETLKDIGADVRWASCNIFSTQDHAAAAIAATGTPVFAWKGETLEEYWDCTLDALTFTLADGTLTGPELVVDDGGDVTLLIHKGYELENGSDWVNTASASHEEQVIKNLLKRVAKERPGYWGRVVKDWKGVSEETTTGVHRLYQLAQAGTLLIPAINVNDSVTKSKFDNLYGCRESLADGLKRAMDVMLAGKVAVVCGYGDVGKGCAASLRAYGARVIVTEIDPICALQAAMEGYEVNTIESTLGRADLYVTTTGNKDIIRIEHLSAMKDQAIVCNIGHFDNEIQVDALVSFAGIKHVNIKPQVDKYIFPNGNAIFLLAEGRLVNLGCATGHPSFVMSNSFANQTLAQIDLWANKDSYEKKVYLLPKKLDEEVARLHLEKIGVKLTTLSQEQADYIGVPVEGPFKPDHYRY
>NC_015947.1|WP_014036004.1|733373_735890_+|prolyl-oligopeptidase-family-serine-peptidase
MSMHVRRTRRWTGLVLSMGLLAVAPLAWAAAPQPAAAQAQGVNGYELPSAALQAVVDAPRAPSLYLSPRRDVAAMMQMPSLPSIQVVAQPELKLAGLRINPRTFSDSRFSFGEKLWLMNVADGKERQISGLPAKLSIASVMWSPDQKWLAFNQVDAASGANELWLVDVAGGSARRLVAGLNTVIGSGYQWLPDSRGLVVFTRPANLGAAPAADGIPTGPAVQQTRQGDGVVSIRTYQDLLKNEADARQFDYYATTQPVEVSLDGNTRAIGAAGIFMGFSVSPDGRFVLRQPVQRPYSYVVPVSSFPRRIEVIDRASGKLVHTVAVRPLVEGLPTGNDAEVTGVRDIGWRGDAEATLVWAEAQDGGDPNKDAKVRDAVLMQAAPFDKPPVTLAQLGSRLAGISWGRGDLALLTESWWKTRRTRTWLIAPDNASAEPRLLWNRDAQDRYADPGRPLLASDERGRSLLQTSPDGSSLYLAGAGASPEGDRPFVDRFDIATGKATRLFHSQAPSYALPVALLDDQASSLLLSRESPDEPANFYVQSLADAGAAPRALTHFAHPLPQLKGVQKEQIRYKRKDGVDLTATLLLPPGYDPKRDGPRPLLMWAYPGEFKSAAAASQVTDSPYRFNAVSYWGPQAFLAKGYVVLASPSMPIIGEGDKEPNDTYIEQLVANAQAAVDEVVRRGVTDRDHIAIGGHSYGAFMTANLLAHTRLFKAGIARSGAYNRTLTPFGFQAEERNYWQAQDVYQKMAPFNYADRIKDPILFIHGVDDNNSGTFPIQSERMFAAVKGLGGTARLVMLPNESHAYRARESIMTMLAESERWLEQTIGPAEQGKAKKKR
>NC_015947.1|WP_014036005.1|736062_738774_+|phosphoenolpyruvate-carboxylase
MNEYRSSIEFASPDLPLRDDVRRLGALVGDLLVEQVSAAFLDDVEDVRTRAIARRENQAPLSELADGLAGRTPQQAETMVRAFSTYFQVVNIAERVHRIRRRRDYQRAGTAGAQPDGLQDALQHLKAQGVGLDELAQWLPRIDIEPVFTAHPTEAVRRALLEKEQLMVASLVDNLDGQRTPGEAAADAARFRMALTASWQTTDSSPVRPTVDDEREHVGFYLVQVLYRVIPVLYESLQQALRDTYGEELPLPRLLRFGTWVGGDMDGNPNVDAHTIRNTLDAQRQAVLARYQKELLQLASLLSQSTERVGVSDALQARVVQYQQLLPQVQSRPRHADMPYRLLNDRMRARLQATLDDGEGAYAGPDELIDDLQLILDSLRANRGEHAGGFAVQRLLWRVKTFGFHLARLDVRQESSVHARALATVLGGDAAWDGLDALGRARLLAPHASGDAPLPKGDDEGNRRLDAVFAALADARARHGGDALGSYIISMAHDRSDVLAVLALARRGGLVEAGGAVPLDIAPLFETVDDLKRGTATLRDLLADPVYRAHLHARDDVQMVMLGYSDSSKDGGIAASRWGLQRAQVELLEVAAEAGIRLTFFHGRGGSISRGGGKTTHAVDASPRGSIDGRLRVTEQGEVIHRKYGIRALALRSLEQATGAVLRASLRPRAAEPREDDWRPVMDAVASASSEVYRAFVGQAGFMDYFRTATPIDVIERMTLGSRPSRRLGQDAALGNLRAIPWVFAWSQARAVIPGWYGVGSGLQAAVDAGREQTLRDMARDWPFFRTFLDDIAMVLSKGDITIAEQFSLLSGDLHERFFPQVQRELELTRHWLLVLMDQKTLLDHDARLALSIRLRNPYVDPISVLQVDLLQRWRASGREDDELLRALVACVNGVSQGVQNTG
>NC_015947.1|WP_014036006.1|738861_739368_-|acyl-CoA-thioesterase
MSTELKTHQLSMTVLMSPEMANFSGKVHGGAILRLLDQVAYACASRYAGSYVVTLSVDQVMFRQPIAVGELVTFLASVNHTGTSSMEIGIKVVAEDILKRSVRHANSCFFTMVAVDEEGRPTPVPPLQPVTSDEKRRQAAALIRRQLRQEMEQRHLELLASNPPSPEE
>NC_015947.1|WP_010481882.1|739506_740718_-|methionine-adenosyltransferase
MSSYLFTSESVSEGHPDKVADQISDAVLDAILTQDQRARVACETMVKTGVAIVAGEITTSAWIDLEALTRKVITDIGYDSSDVGFDGATCGVLNLIGKQSPHIAQGVDRKKPEEMGAGDQGLMFGYATNETDSYMPAAIHLSHRLVEQQAKIRKKKNSPLSWLRPDAKSQVTLRYENGVVSAIDAVVLSTQHAPGIKQKDLIEAVREEIIKPVLPAKWLHKGTKFHINPTGKFEIGGPVGDCGLTGRKIIVDTYGGWARHGGGAFSGKDPSKVDRSAAYAARYVAKNVVAAGLADRCEVQVSYAIGVAEPTSISVTTFGTGKISDDKIEKLIRKHFDLRPYGIIKMLDLVHPMYQQTAAYGHFGRKPKEFSYLNGEGETVNATAFSWEKTDRAAALRADAKLK
>NC_015947.1|WP_014036007.1|741053_742769_+|GNAT-family-N-acetyltransferase
MQELEQRLQQRFPDWFHGRRGQLARPLLRSVGRWSRLDQIEAFLQRSSGLRGFGFVAAGLEFIDGQYQVDPAALAKIPATGRLLIVANHPSGALDALALLDAVGRIRRDVRIVANDLLGAIAPLQDLLLPVRILGGKAQRGSLHAVEEALAAEQCVIVFPAGEVSRLSLRGIRDGRWQRGFVRFARAAGAPVLPVRVEARNSALFYGASTLFKPAGTALLAREMFTRRGRPLRLSIGEPMQLGKGGDPGAQLLAVRRALYALGRNGAAGDAAAVAGPEPLASPVPPSQVAAGIAASTQLGQTADGKQILLATCTADSPLLLELGRLRELTFRQVGEGTGRSRDLDDYDPQYEHIVIWDAAAQRIAGAYRIMRGAQALARHGLSGLYSASLFRYSDDAITHIAEGLELGRSFVVPDYWGSRSLDYLWQGIGAYLQCRPGIRYLFGAVSISAALPRDAREQLVAYYQRYYSGTAGLAESNRPFQYFAAPPSFGELDAGAAFDVLKANLAALGTGVPTLYRQYTDLCEPGGARFLAFGVDPDFSDSIDGLIEVDLCAIRPNKRKRYLRDAGTPA
>NC_015947.1|WP_014036008.1|742765_743566_+|UDP-2,3-diacylglucosamine-diphosphatase
MSTLANLSPHRRAVFVSDVHLGSRHCHATELARFLSQLRCERLYLVGDIIDLWWMAHRRANWRQSHSEVIQALHALRRAGTEIIYIPGNHDASLRHVCGLMLPAMQVRRRAIHVTADGRRLLVAHGDDYDGVTHFGGLQEKFGDWLYYRILTGNQALNAVRRRLGMRYWSLSEFLKKRSGAAERYIERFVQAGLDDVRRRGLDGIVCGHIHRAALVERDGLVYANDGDWVESLTALAEDHDGALRLLDHNGQTLVELPGARIKQAA
>NC_015947.1|WP_014036009.1|743770_744829_+|metal-dependent-hydrolase
MDSLTQIVLGGAVAAAIAPPGHRRAALLAGAALGTLPDLDALWLGFTAADPVANMIEHRSFSHSLLVLPWVATLIWWLFKRFGNGRVAQSPVRWFWAIQLALVTHPVLDAFTVYGTQLWWPLRPHPTMGSSVFIIDPGYTVWLLLGCVLAWFGRARPWAGKVLGVALLLSSGYLGWGLIAKAQVDRAAQQSLAAMGLGDAPRFSVPMPFNTLLWRVVAMTPNGYVVGDRSLVADHGPMRFEGHASNVQALREAQAIPAVQQLQWFNRGFMRAQVVDGRLVLSDLRMGLEPDYTFNFVVAEQADGQWRAITPEQVRVDYSSPAARADAGRRLAAMWQRIWQEPAASATGAAHP

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Crispr_ID: NC_015947_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015947_6

2586155-2586254

Orphan

Consensus_repeat	Method
CCGGCCAGCGGCCGGCACTACCGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015947_6

>merge|NC_015947|6|2586155-2586254|CRISPRCasFinder
CCGGCCAGCGGCCGGCACTACCGTAGATCGCGGGGTTGCCGGCCGGTGGCCGGCACTACCGTAGATCGCGGGGTTACCGGCCGGCGGCCGGCACTACCGT

>NC_015947|6|6|2586155-2586254|CRISPRCasFinder
CCGGCCAGCGGCCGGCACTACCGT	AGATCGCGGGGTTGCCGGCCGGTGGCCGGCACTACCGTAGATCGCGGGGTTA
CCGGCCGGCGGCCGGCACTACCGT

Protein	Signature genes	Signature genes Name	Protein_function
NC_015947.1\|WP_010485170.1\|2600701_2601055_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|182471
NC_015947.1\|WP_005409961.1\|2578442_2579099_+\|HTH-type-transcriptional-repressor-FabR	unknown	unknown	gnl\|CDD\|236881
NC_015947.1\|WP_014037490.1\|2576119_2577268_-\|acyl-CoA-desaturase	unknown	unknown	gnl\|CDD\|239583
NC_015947.1\|WP_014037504.1\|2596290_2597235_+\|DUF4880-domain-containing-protein	unknown	unknown	gnl\|CDD\|226235
NC_015947.1\|WP_014037495.1\|2582839_2584171_+\|divalent-metal-cation-transporter	unknown	unknown	gnl\|CDD\|234815
NC_015947.1\|WP_014037498.1\|2586267_2588631_-\|ribonucleoside-diphosphate-reductase-subunit-alpha	unknown	unknown	gnl\|CDD\|181700
NC_015947.1\|WP_014037502.1\|2595244_2595625_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319923
NC_015947.1\|WP_080011133.1\|2584586_2585054_-\|flavodoxin	unknown	unknown	gnl\|CDD\|181744
NC_015947.1\|WP_014037492.1\|2579375_2581529_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|238657
NC_015947.1\|WP_014037506.1\|2600378_2600702_-\|multidrug-efflux-SMR-transporter	unknown	unknown	gnl\|CDD\|224987
NC_015947.1\|WP_014037497.1\|2585079_2586120_-\|ribonucleotide-diphosphate-reductase-subunit-beta	unknown	unknown	gnl\|CDD\|236591
NC_015947.1\|WP_014037494.1\|2582251_2582722_-\|manganese-binding-transcriptional-regulator-MntR	unknown	unknown	gnl\|CDD\|182927
NC_015947.1\|WP_014037500.1\|2590342_2592970_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|238657
NC_015947.1\|WP_014037499.1\|2589063_2590041_+\|zinc-binding-dehydrogenase	unknown	unknown	gnl\|CDD\|176252
NC_015947.1\|WP_014037491.1\|2577279_2578389_-\|ferredoxin-reductase	unknown	unknown	gnl\|CDD\|99812
NC_015947.1\|WP_014037505.1\|2597304_2600253_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|273808
NC_015947.1\|WP_014037503.1\|2595775_2596294_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|171561
NC_015947.1\|WP_014037493.1\|2581518_2582067_+\|redoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|239262
NC_015947.1\|WP_005409967.1\|2584288_2584615_-\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239245
NC_015947.1\|WP_014037501.1\|2593069_2595049_-\|BCCT-family-transporter	unknown	unknown	gnl\|CDD\|236635

Protein	Function_ID	Function_description	E-value
NC_015947.1\|WP_010485170.1\|2600701_2601055_-\|hypothetical-protein	gnl\|CDD\|182471	PRK10452, PRK10452, multidrug/spermidine efflux SMR transporter subunit MdtJ.	1.33763e-24
NC_015947.1\|WP_005409961.1\|2578442_2579099_+\|HTH-type-transcriptional-repressor-FabR	gnl\|CDD\|236881	PRK11202, PRK11202, HTH-type transcriptional repressor FabR.	6.42982e-48
NC_015947.1\|WP_014037490.1\|2576119_2577268_-\|acyl-CoA-desaturase	gnl\|CDD\|239583	cd03506, Delta6-FADS-like, The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases are required for the synthesis of highly unsaturated fatty acids (HUFAs), which are mainly esterified into phospholipids and contribute to maintaining membrane fluidity. While HUFAs may be required for cold tolerance in bacteria, plants and fish, the primary role of HUFAs in mammals is cell signaling. These enzymes are described as front-end desaturases because they introduce a double bond between the pre-exiting double bond and the carboxyl (front) end of the fatty acid. Various substrates are involved, with both acyl-coenzyme A (CoA) and acyl-lipid desaturases present in this CD. Acyl-lipid desaturases are localized in the membranes of cyanobacterial thylakoid, plant endoplasmic reticulum (ER), and plastid; and acyl-CoA desaturases are present in ER membrane. ER-bound plant acyl-lipid desaturases and acyl-CoA desaturases require cytochrome b5 as an electron donor. Most of the eukaryotic desaturase domains have an adjacent N-terminal cytochrome b5-like domain. This domain family has extensive hydrophobic regions that would be capable of spanning the membrane bilayer at least twice. Comparison of sequences also reveals the existence of three regions of conserved histidine cluster motifs that contain the residues: HXXXH, HXX(X)HH, and Q/HXXHH. These histidine residues are reported to be catalytically essential and proposed to be the ligands for the iron atoms contained within the homolog, stearoyl CoA desaturase.	2.08063e-44
NC_015947.1\|WP_014037504.1\|2596290_2597235_+\|DUF4880-domain-containing-protein	gnl\|CDD\|226235	COG3712, FecR, periplasmic ferric-dicitrate binding protein FecR, regulates iron transport through sigma-19 [Inorganic ion transport and metabolism, Signal transduction mechanisms].	1.9815e-53
NC_015947.1\|WP_014037495.1\|2582839_2584171_+\|divalent-metal-cation-transporter	gnl\|CDD\|234815	PRK00701, PRK00701, divalent metal cation transporter MntH.	0
NC_015947.1\|WP_014037498.1\|2586267_2588631_-\|ribonucleoside-diphosphate-reductase-subunit-alpha	gnl\|CDD\|181700	PRK09209, PRK09209, ribonucleoside-diphosphate reductase subunit alpha.	0
NC_015947.1\|WP_014037502.1\|2595244_2595625_-\|VOC-family-protein	gnl\|CDD\|319923	cd07262, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	5.22362e-46
NC_015947.1\|WP_080011133.1\|2584586_2585054_-\|flavodoxin	gnl\|CDD\|181744	PRK09271, PRK09271, flavodoxin; Provisional.	2.47053e-89
NC_015947.1\|WP_014037492.1\|2579375_2581529_+\|TonB-dependent-receptor	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	1.18667e-59
NC_015947.1\|WP_014037506.1\|2600378_2600702_-\|multidrug-efflux-SMR-transporter	gnl\|CDD\|224987	COG2076, EmrE, Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism].	2.44845e-21
NC_015947.1\|WP_014037497.1\|2585079_2586120_-\|ribonucleotide-diphosphate-reductase-subunit-beta	gnl\|CDD\|236591	PRK09614, nrdF, ribonucleotide-diphosphate reductase subunit beta; Reviewed.	3.5256e-126
NC_015947.1\|WP_014037494.1\|2582251_2582722_-\|manganese-binding-transcriptional-regulator-MntR	gnl\|CDD\|182927	PRK11050, PRK11050, manganese-binding transcriptional regulator MntR.	1.50343e-83
NC_015947.1\|WP_014037500.1\|2590342_2592970_+\|TonB-dependent-receptor	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	2.95473e-66
NC_015947.1\|WP_014037499.1\|2589063_2590041_+\|zinc-binding-dehydrogenase	gnl\|CDD\|176252	cd08292, ETR_like_2, 2-enoyl thioester reductase (ETR) like proteins, child 2. 2-enoyl thioester reductase (ETR) like proteins. ETR catalyzes the NADPH-dependent conversion of trans-2-enoyl acyl carrier protein/coenzyme A (ACP/CoA) to acyl-(ACP/CoA) in fatty acid synthesis. 2-enoyl thioester reductase activity has been linked in Candida tropicalis as essential in maintaining mitiochondrial respiratory function. This ETR family is a part of the medium chain dehydrogenase/reductase family, but lack the zinc coordination sites characteristic of the 2-enoyl thioester reductase (ETR) like proteins. ETR catalyzes the NADPH-dependent dependent conversion of trans-2-enoyl acyl carrier protein/coenzyme A (ACP/CoA) to acyl-(ACP/CoA) in fatty acid synthesis. 2-enoyl thioester reductase activity has been linked in Candida tropicalis as essential in maintaining mitiochondrial respiratory function. This ETR family is a part of the medium chain dehydrogenase/reductase family, but lack the zinc coordination sites characteristic of the alcohol dehydrogenases in this family. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site, and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains, at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. Candida tropicalis enoyl thioester reductase (Etr1p) catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis. Etr1p forms homodimers, with each subunit containing a nucleotide-binding Rossmann fold domain and a catalytic domain.	2.72216e-165
NC_015947.1\|WP_014037491.1\|2577279_2578389_-\|ferredoxin-reductase	gnl\|CDD\|99812	cd06216, FNR_iron_sulfur_binding_2, Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently bound FAD as a prosthetic group) are present in chloroplasts, mitochondria, and bacteria in which they participate in a wide variety of redox metabolic pathways. The C-terminal domain contains most of the NADP(H) binding residues and the N-terminal domain interacts non-covalently with the isoalloxazine rings of the flavin molecule which lies largely in a large gap betweed the two domains. Ferredoxin-NADP+ reductase first accepts one electron from reduced ferredoxin to form a flavin semiquinone intermediate. The enzyme then accepts a second electron to form FADH2 which then transfers two electrons and a proton to NADP+ to form NADPH.	3.82462e-95
NC_015947.1\|WP_014037505.1\|2597304_2600253_+\|TonB-dependent-receptor	gnl\|CDD\|273808	TIGR01786, hemoglobin-haptoglobin-binding_protein, TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein. This model represents a family of TonB-dependent outer membrane receptor/transporters acting on iron-containing proteins such as hemoglobin, transferrin and lactoferrin. Two subfamily models with a narrower scope are contained within this model, the heme/hemoglobin receptor family protein model (TIGR01785) and the transferrin/lactoferrin receptor family model (TIGR01776). Accessions which score above trusted to this model while not scoring above trusted to the more specific models are most likely to be hemoglobin transporters. Nearly all of the species containing trusted hits to this model have access to hemoglobin, transferrin or lactoferrin or related proteins in their biological niche. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins].	4.20436e-30
NC_015947.1\|WP_014037503.1\|2595775_2596294_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|171561	PRK12528, PRK12528, RNA polymerase sigma factor; Provisional.	7.3416e-47
NC_015947.1\|WP_014037493.1\|2581518_2582067_+\|redoxin-domain-containing-protein	gnl\|CDD\|239262	cd02964, TryX_like_family, Tryparedoxin (TryX)-like family; composed of TryX and related proteins including nucleoredoxin (NRX), rod-derived cone viability factor (RdCVF) and the nematode homolog described as a 16-kD class of TRX. Most members of this family, except RdCVF, are protein disulfide oxidoreductases containing an active site CXXC motif, similar to TRX.	1.63217e-23
NC_015947.1\|WP_005409967.1\|2584288_2584615_-\|thioredoxin-family-protein	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	5.02695e-18
NC_015947.1\|WP_014037501.1\|2593069_2595049_-\|BCCT-family-transporter	gnl\|CDD\|236635	PRK09928, PRK09928, choline transport protein BetT; Provisional.	0

>NC_015947.1|WP_014037497.1|2585079_2586120_-|ribonucleotide-diphosphate-reductase-subunit-beta
MATPLDRIKILEPRHPNRSTGIINGRTSGILNWNDIPYPSFYRAYKELSTNFWIPDEVDMKADARQYGELSGREKNAYDSIIGLLATLDSPQTRFIYNVAEYITDPAAHANAAIIGQQEVIHNESYSYVLASITDLPNQNRVFELARTHPTIIKRNAPIMGAYDDFMREKTAETLLKSLIQSSILEGINFYSGFAYFYNMVRQNRMTGTGKIISFINRDELAHTKFISELIRAIIGENPELQTNEMTAYVHQAFEHAIELETQWSSEVLDGIDGIDVEEMTRYVKYRANKMAGMLGIERLYSDTTDNVMPWIKAYADNFTETKTDFFEMRNASYKKTNVDNGFDDL
>NC_015947.1|WP_080011133.1|2584586_2585054_-|flavodoxin
MVVASLSGNTRELGRQIAERCRAAGHAVHWQEADDLRQAPPLAADEADLVLLGCWTDNAGRTPAEMKAWVAGIAERGERPRQLAVFGTGETQWGQEYYCGAVHRLIRYFHSDYPPLEIEQMPHGERHAAAIEAWTDAVLSHYWSNTDADHRRHHA
>NC_015947.1|WP_005409967.1|2584288_2584615_-|thioredoxin-family-protein
MQIIDATTPEQFQQLLAEHPRVLVDFHKDQCPGCRMLEMSLHRVANSVAGQGTTLLRVQLEVLGEAFFRELGLRQTPTLSLFRDGDERTRLAGFQSPQQIEAAIALHL
>NC_015947.1|WP_014037495.1|2582839_2584171_+|divalent-metal-cation-transporter
MNTLAPRDPSASTPASLGALNASVAVPDKGHWWFRLLAFLGPGYMISVGYMDPGNWATDLAGGSRFGYLLLSVILISNLMAVILQALSARLGIATGMDLAQACRARYPKPVNLALWALCEAAIIACDLAEVIGTAIALKLLFDLPLLWGAVITALDTLLVLLLMNRGFRALEAFVIALLMVIFACFLVQIAMAAPPVMAVLGGFIPRAQVVTDPHALYIAIGIIGATVMPHNLYLHSSIVQTRAYPRTDEGRRSALRWAVTDSTIALTLALFINASILILAAAVFHANGRFDVEDIEQAHQLLAPMLGVGAAATLFAIALLASGLNSTVTATLAGQIVMEGFLHLRLPPWLRRLITRALAIIPVVVVIMLFGDQGAVKLLVLSQVVLSMQLPFAIIPLVRIVTDKVTMGALVAPRWLGVIAWVIALVIVVLNVKLLVDTFTGG
>NC_015947.1|WP_014037494.1|2582251_2582722_-|manganese-binding-transcriptional-regulator-MntR
MGKTDDSTSLKSTPLIEAERQVESFRQVREAHRMELVEDYVELISDLLADGGEARQVDIATRLGVAQPTVAKMLRRLARDGWVVQRPYRGVFLTPEGEALAHASRQRHQTVERFLLALGVDPDTARRDAEGIEHHVSEQTLALFEAFVRKAEGGAP
>NC_015947.1|WP_014037493.1|2581518_2582067_+|redoxin-domain-containing-protein
MRSELHRALLLACAVLLAAPAMAADLHAQVSASLMRPEQRSLRPMQWSPPPKLVALYFGADWCAPCHAFVPTLRSVRDALREAGADTEVVYVSLDESEAALRRYMHAQDMPWPVLDPRRAARMPALQALAGMAPPNLVLIDADGNVLANGWHGRRYDGLQPVLKEWTKRACAQEQARCPPGL
>NC_015947.1|WP_014037492.1|2579375_2581529_+|TonB-dependent-receptor
MPVSLLRRLPLAAAIALTLPLPTVAATPKPTELDRVQVKVSTATRSERLLSDVPIRTEVLRKEDIALRAATDFSRAAELINGLRVESNCQNCNTSEVQLLGLPGAYNQLLFDGIPLLSTLGSVYGLEQIPAGFVDRIEVVKGGGSALYGPGAVAGVINLIPPLPARSGGHVQAGVDVLKGTPQKNADVRLDLVAKDADAGLSVIAQRNWNSGIDYNGDGYTEITRKNLKVGGLQAWYAPTPGTRLRLDLQVTDETRRGGNRLDQPEYLANIAESLDTKYRRGSVSWDQEINADVDFRLAYAFADIDRDSFYGGLGDVVTDPSAPGYDPSQLDPNVAGSAASRSWRQYGRTHNPLHYIDSQLNWRLGAHALAFGVQYKHEALRDDNRTGDGQRLAVLEDATFHNLGAFIQDEWSLRDNVDLVLGARVDKSSELDNAVFSPRIALAWQATPNLKWRAGVATGFRAPEIFVEDVHVDTLGGEQVRVRNTDGLKEERALTTLFGFDWRSDPANPVWSWDATASYARIRDTFALGEIQRGDDGQLSQLRYNASGSNVLGAETNLGWQPSPQWRLTAGASWYRSRFREPQRIFDDTGDGGDTVIESRDYLKTPRWTGLAQLSWMPAEPWETFVALRHTGPMSVLNNRLGELHRTRSFLVTDLGARWHRHLGAQAQQEVSVAAGVKNVFDQRQKDLEVGALRDSDYVYGPRFARSWYVNLRYAF
>NC_015947.1|WP_005409961.1|2578442_2579099_+|HTH-type-transcriptional-repressor-FabR
MAAATALSTPEDANSPARRTVSREDLLAAALKLIGPHRSLSTLSLREVAREAGIAPNSFYRQFRDMDELAVALIDAAGRSLRTIIGEARQRATSTATSVVRVSVETFMEQLRADDKLLHVLLREGAVGSDDFKHAVERELHYFEEELQHDLVRLAALDGAVLHAPELVAKAITRLVFAMGATAMDLPPEKDPELVEQISTMIRMIIVGARTPAAFRRG
>NC_015947.1|WP_014037491.1|2577279_2578389_-|ferredoxin-reductase
MYTQVYVRPYSSPMSAVVRPSLFSPYRWVSPSLFDFWAGQFNPLWTLREPVARLVRREPAGEGAATLVLRTNRHWAGMRAGQHVTLGVEIEGRLWQRSYSPTALGPRELAITVKAVDGGRVSQHLVNHAQPGELFRLDAAFGEFHMPAAAPVLLLAAGSGITPMRSLLREACQRPLAAPVDLFYWERSAAHLQFRDELQALAASQPNLRVHLLTTREGDVPAARIDAHDLQVAGDDTPLAQRHVLACGPDGFVAAARERLAHQVAGFQAEAFTPPAPLRDASSEGEVVLTLARSGRQLSVPRGSSLLESLEAHGIKPKHGCRMGICNTCSCDRVSGATRHLRTGDLQSESAQPVRICVSAPTTDLTLDL
>NC_015947.1|WP_014037490.1|2576119_2577268_-|acyl-CoA-desaturase
MTRATDRALSTAEMHAFGEELDAIRDRVIGSLGASDTRYIRRVAAAVRWFGVGGRGLLFLAAFSPLFWMPLLWPAAITGTLLLALSKILENMELGHNVMHGQFDWTGDPKLNGNTYEWDIVATADNWRKTHNFRHHTYTNVRGMDDDIGYGLLRIFPEQRWKPFYLLQPIFAPIFALLFQWGVAAQDLRLGRWLKGRMSARAMWLQTRPVARKMLRQVLKDYVFFPLLAGPFFLTVMLGNLVANGLRNIWTYVIIFCGHFTAESETFPKECLRNESRGHWYLRQLRGSSNISGGFLINVLSGNLSHQIEHHFYPDLPANRYAAIAKEVKDICRRYGQHYNNGSLPRQFGQVVWRILRHAFPSKPRRLPMSDIMSAPASANAG
>NC_015947.1|WP_014037498.1|2586267_2588631_-|ribonucleoside-diphosphate-reductase-subunit-alpha
MTDNTYRAADLAGAGDALRAGGERVPTWITKEAGNRRLPFDAERLQRSIDAVHAELPQLDVSDYRRVVQAMVERKPSISADDLVDLLIREAESRVDLVAPEWEQFAARIYLRRLYKRASRNRFYDVSLKYGSYVGLQESLADRGIYSNDILRCYSKEELQQAGEMIDPDRDRLFAYNGLYLLATRYLASDRSREVYELPQERWLTIALYLMQEEKPRERRMQLVGEAYWALSNLYMTVATPTLANAGKVGGQLSSCFIDTVDDSLQGIYDSNTDIARVSKHGGGVGAYLGYVRSSGAPIRGVPNSSGGVVPWIKQLNNTAVSVDQLGQRKGAVAVYLDIWHRDIEAFMDLRLNNGDQRLRAHDVFTSVCVPDLFMEAVERRADWYLFDPHEVKQAKGWYLQDFYDEKRGAGSFRDRYAELVADERISRRTVKAIDLFKRIMLSQLETGNPFLFYRDEVNRRNPNKHAGMIYSSNLCTEILQNMSPTRMIQEIVSGDQIVTTRRAGDFVVCNLSSINLGRAISAPDDLLATDVLERLIPIQVRMLDNVIDLNALPVPQATITNRKYRAIGLGTFGWHHLLAQQAIQWDSPDAEQLADRLYERINFLTIQASMQLAKEKGSYPMFAGSDWHNGRYFSDRDYSGAAWDSLAREVATHGLRNGWLLAVAPNMSTAQIAGSTASIDPIYSAFYYEEKKDFRRPVAAPGLSLETWPYYEKGAYKVDQFASVRQNARRQRHVDQSISFNLYVPSTIRASTLLDLHLSAWREGLKTTYYVRSNDIDISECEWCSS
>NC_015947.1|WP_014037499.1|2589063_2590041_+|zinc-binding-dehydrogenase
MRAAQYPSFGDPADVLSIADAALPEPGPGEVRIRTVLASIHNHDLLTVRGLYGYKPMLPAIGGSEALGVVDALGEGVNGLQIGQRVAAASVHGTWAEAFIAPARMVIPMPDAIPDEMAAQLIAMPLSALMLLEFLHVEAGQWIVQNTANGAVGKSLAMLARARGVHVANLVRNADAVAQLQALGIDHVFDTSVDGWKDRVRAATGEAQAAAAVDSIGGDASGDLVDLLGHHGTLVSFGVMSGEPMRIPAGGLIYKEATVKGFWGSKVSQAMAVEDKRRLVGELLKRAASGELTLPVEQVFALDDIAQAVKAGAGSGRNGKVLLRP
>NC_015947.1|WP_014037500.1|2590342_2592970_+|TonB-dependent-receptor
MYRTTLNLLAGAIALGLTAGAAGAAETADTGKDSTTLGTVLVTGSNIKRSDTAGPNPVQIVSREQIEQTGRSTLTDVLRNLSANAGNSFDEQYTGSFAAGSASIGLRGLSPKNTLVLVNGYRVSNFGFALNTQDTFVDLNALPISAVERIEVLKDGASAVYGSDAIAGVINIILRRNFQGVEVGGGFGTATQGGLDERKANLLAGFGDLEQQGWNVLFGLDLLKRDRLDGDDRAYTRSGDFRDKPGGRLAGWSTAGGNWLSNPRAPQPFANCPEGSQLRPYSDFGSTLPGQACAFNAQPFKTLQPGAERLQASLSATYRFNDSVEAFADVLYSHNKADQIFSAPLTVGPGLRAYNPATGTLIDVPAVLPVGHPNNPGSTPLPFEYTFFDLGPRLKDNTQVFYRALAGVRGSGERWDWEVAALTSQSAQREYVDNFVNRYAFEQILRDGSYNFLNPSSTPGALDALRLQTKRPGWYKLHSLNVKASTSLWELPAGTVGFAWGAEFRKESLDARTSAQVLSGTELRPAINVVNGERQVSAAYAELSVPLHRTLELQLAGRGDHYDDFGKAFSPKVALRWQPLDSLLLRGSFSRGFRAPSLPEIAPGQTVSYGSVIDPLDPLQPGGSRGVTNIRTGNPDLKAERSRNFNVGAVWSPDGDTSIGLDWYRIEQDNLVKPDSAQFIVDNPTLFPGRVQRDAQGRITFITNQYANQGELTTSGLDLDANHTFRTEGWGSFTVAGSWTHLLSFKQPLVAGQAPYEGAGNNRHGALPRTRGTTSLNWAVGDWSSTLSLQYVSGYDQRVATATSNPGLRDRVKPYHQLDLYVAYEGIPNTTLSLSVLNLTDKDPPFDPAGGSNGFDISQYNLRGQFVSLGARYRF
>NC_015947.1|WP_014037501.1|2593069_2595049_-|BCCT-family-transporter
MEVLEPQQSPVRTLRPVFAFAAIVVVAFALFVSLFPLGAGRLLVKAQDWAALNVGWYYLLAMTLYLVFVVGVALSKYGGIKLGADHDEPEFSYLSWAGMLFAAGISITLFFFCVSEPLTHYLQPPQGDPAAGEAGARQAMQLLFLHWGLHGWGVFALAAMAMAYFAYRHNLPLALRSALYPLIGKRINGPIGYTVDALGIVATVFGIGADMGFGVLHLNAGLSHLFNIPHSNLVQIILVVSMMGAAVAVAVSGVEKGVRWMANINMLLAIALVLFMLCAGPTQYLLSTLMQNLGDYLGSVVGKSFDVYAYGGRPEWLGGWTVFYWAWWIGWAPFVGLFIARISRGRTIREFVFGVLLIPLGFTLAWLSIFGNSALDQVLHHGQQQLAQLAVDDPPTVLYALLDGYPWSRTVIAVTVLVSFIFFVTSADSGAVVLSTLSSHGGAPEDDGPRWLRVFWGTVIAVLTAGLLLAGSIDALKSAVVLASLPFSAVLLLMMWGLTRAFSDESHRKRALQYRPSPLIGDDRHHQGWRQRLSQAMHFPVRDQVYRFMDDTVKPAMEAVAEQLRGQGWDVATRFEAGDMELTVNHGEQQDFLYRVILSGYLTPSFAAQQLRNQRYYRAEVHLFEGSQDYDLVGYSRKQIINDIISQYERHLQFLHLSR
>NC_015947.1|WP_014037502.1|2595244_2595625_-|VOC-family-protein
MFSHITVGTNDMDVAHRFYDALFTALGARPGVFDDKGRLVYFKDGRMFIVTAPIDGQPACHANGGTIGFTLDSAEAVRGWQDAGVAHGGTAIEDPAGIRNMAGRQLFLAYLRDPDGNKLCAVHVMS
>NC_015947.1|WP_014037503.1|2595775_2596294_+|sigma-70-family-RNA-polymerase-sigma-factor
MAVPAASSTALAGFYREHHGWLLGWLRRRTHNADCAADLTQDTFLRLLSRRVDPSELRLPRAYLSTIAHALLVNHWQRADLERAYLAALAAQPEPVHPSAEERTQALQLLHAIADMLSGLAERPRRAFLLARLSGLGYAEIGQQLGVSERMVKKYMAQAMLHCLRLSGDAAA
>NC_015947.1|WP_014037504.1|2596290_2597235_+|DUF4880-domain-containing-protein
MNAALASPALEQAAEWFALRQQGWSDSDQQRWHAWLHADAGHADAWRRVETVWQSFAPLSAPAAVTALDAAGRRRRRALRSLGGALGIGAVSLLGLHGLREQRGLQTQRTAAGHTGHWTLMDGSQLWLNADSEVTIDIGNGRRTLHLLRGELLLQTGHHPAHAGLPLTVHVPGARLQPIGTRFAVGREAQGSRLDVFEGVVRCLPLFGAALDVPTGGAARIGPMGGLSTVDADPLRGDWQDGRLQVQHAPLIRVIDELGRHHQGYLGCDPALAALNVTAVLPRLDSLQALQLLARALPIRIEQRWPWWTVVRPL
>NC_015947.1|WP_014037505.1|2597304_2600253_+|TonB-dependent-receptor
MKLPCPSPRPLAIALCMALATPCLLPATVHAQDTTAAVRWQIQAGPLDQALTAFGQQSGLSIAADARLTRGRHSNGVHATLGTDAALAQLLAGTGLTFQRDANGVALQAAPDAEAGVRQIGTLRVAGQASEGASPWGLADADAVYRDSGSRVHLDRQQLERFRGQSIGDVLAGAVGVHTADVRNGGALDVNIRGLQGQNRVPVIIDGGQQAIDVYRGYAGVQQRSYLDPDLISAVSIEKGPSLAANAASAIGGVVYMETLNVDDILDDGQAWGLRVRGGVADNSIDRTRVFKQVARGSENRNSLRDPRDWNGSVAFAQRGEDWQLVAAYARRRQGNYFAGSNGAHRYDDQHLSSGGTGMSSQAVSDMYHPGDEVLNTHTDNESALLKFTWTPNPDQRLELSHRYFNSSFGEIMPSAIGRVGESNEWVTYVDKANTMFQFEPGKMRVNATSLRHRYRPEAHPWLDLSSTLWFTTATSRMFNSNIANTPLFKEMASDQMPDTLGETYGPGLQSDVKTQRWGVDSSNTTRFSNGLGDWTLRYGASFQHEDTAPNSPVLPVDYNNNRYLRSGTRRESSVVASLQWQPWDWLSLTAGGRFIDYRTRDRNRVAFVSESRDLRYTFARLSKGGQLLPGWYKEWYPDAQGNYTYDSLRATPYGDSTLGQTYDFDGFIPDPRGANGFYTKQIPTAWGYKPAIRRSGHGFAPYAEARFNLDADMFFYVKYAQGWKMPSLFESTLGNSTSAPVADLKPEKNRSWDIGFSLLKQDLWRDGDRLAFKVAWFKNDIDNAITRRFDSSNWAFYVDNVDNYTVSGYELQSGYDAGIAYLDLSASYYQRARTCDAATAKRLREDPYAKWSKLDTTPDCVDGGFGTSFVNAQNPPKYSIHSTLGFRLFDKRLDTGIRRTYNSGPTHELDKPWNTTGSTGLQNIYLPTAIYDFYARWQFTPRSEVELVVSNLRNTYYMDTLAMSLMPGPGRTTRLNFTARF
>NC_015947.1|WP_014037506.1|2600378_2600702_-|multidrug-efflux-SMR-transporter
MNTLALFFVICSALIDVAANMMVAKSEGFRRWRWGVAAIVMVWIAFALLGQAVRYMDLATAYAMWGAIGVIGTATCGRLLFGNRLRPIGWVGIGLVTVAVLLLSTAK
>NC_015947.1|WP_010485170.1|2600701_2601055_-|hypothetical-protein
MSRTVPARGALVAWACLTVAIVAEVVGTSFMAHAARDGGWTGYLIMAGALALSYFFLAQSVRRIAVGVAYAVWEGLGLTLLTVVGLTVFGESLSLQQLAGLVLAVVGIVCVTLGEAH

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Crispr_ID: NC_015947_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015947_7

2861902-2862010

Orphan

Consensus_repeat	Method
AGTCGAGCATGGCTCGACTCTACAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015947_7

>merge|NC_015947|7|2861902-2862010|CRISPRCasFinder
AGTCGAGCATGGCTCGACTCTACAGAAAGGCATTTATCAACAAAGGGCCCGGTCACGATGGCTTGGTCGGTCGCCCCAAGCTTGAGTCGAGCATGGCTCGACTCTACAG

>NC_015947|7|7|2861902-2862010|CRISPRCasFinder
AGTCGAGCATGGCTCGACTCTACAG	AAAGGCATTTATCAACAAAGGGCCCGGTCACGATGGCTTGGTCGGTCGCCCCAAGCTTG
AGTCGAGCATGGCTCGACTCTACAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_015947.1\|WP_014037728.1\|2856931_2857417_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NC_015947.1\|WP_014037738.1\|2870857_2871172_+\|hypothetical-protein	unknown	unknown	unknown
NC_015947.1\|WP_014037737.1\|2870550_2870850_+\|hypothetical-protein	unknown	unknown	unknown
NC_015947.1\|WP_014037726.1\|2855111_2855840_-\|DUF3011-domain-containing-protein	unknown	unknown	gnl\|CDD\|371422
NC_015947.1\|WP_002804494.1\|2867120_2867351_-\|30S-ribosomal-protein-S18	unknown	unknown	gnl\|CDD\|178997
NC_015947.1\|WP_014037722.1\|2847187_2848276_-\|DUF1311-domain-containing-protein	unknown	unknown	gnl\|CDD\|377758
NC_015947.1\|WP_014037732.1\|2862018_2862756_-\|cell-division-protein-ZipA	unknown	unknown	gnl\|CDD\|235308
NC_015947.1\|WP_014037723.1\|2848401_2850930_-\|membrane-bound-PQQ-dependent-dehydrogenase,-glucose/quinate/shikimate-family	unknown	unknown	gnl\|CDD\|274418
NC_015947.1\|WP_006452997.1\|2867362_2867800_-\|30S-ribosomal-protein-S6	unknown	unknown	gnl\|CDD\|179034
NC_015947.1\|WP_014037731.1\|2861384_2861831_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224854
NC_015947.1\|WP_014037730.1\|2860134_2861259_+\|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl\|CDD\|181651
NC_015947.1\|WP_014037724.1\|2851061_2853782_-\|DNA-gyrase-subunit-A	unknown	unknown	gnl\|CDD\|235502
NC_015947.1\|WP_014037734.1\|2866565_2867015_-\|50S-ribosomal-protein-L9	unknown	unknown	gnl\|CDD\|234659
NC_015947.1\|WP_014037729.1\|2857466_2859932_-\|NAD-dependent-DNA-ligase-LigA	unknown	unknown	gnl\|CDD\|236137
NC_015947.1\|WP_006452998.1\|2868658_2868997_-\|iron-sulfur-cluster-assembly-accessory-protein	unknown	unknown	gnl\|CDD\|223393
NC_015947.1\|WP_014037735.1\|2868021_2868564_-\|CbrC-family-protein	unknown	unknown	gnl\|CDD\|367610
NC_015947.1\|WP_014037733.1\|2862802_2866306_-\|chromosome-segregation-protein-SMC	unknown	unknown	gnl\|CDD\|274008
NC_015947.1\|WP_014037736.1\|2869125_2870520_+\|asparagine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235176
NC_015947.1\|WP_014037725.1\|2853999_2855064_-\|S-methyl-5-thioribose-1-phosphate-isomerase	unknown	unknown	gnl\|CDD\|235578
NC_015947.1\|WP_014037727.1\|2855978_2856935_-\|EF-P-lysine-aminoacylase-GenX	unknown	unknown	gnl\|CDD\|273090

Protein	Function_ID	Function_description	E-value
NC_015947.1\|WP_014037728.1\|2856931_2857417_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.62737e-11
NC_015947.1\|WP_014037726.1\|2855111_2855840_-\|DUF3011-domain-containing-protein	gnl\|CDD\|371422	pfam11218, DUF3011, Protein of unknown function (DUF3011). This bacterial family of proteins has no known function. Most members belong to Proteobacteria.	1.95097e-80
NC_015947.1\|WP_002804494.1\|2867120_2867351_-\|30S-ribosomal-protein-S18	gnl\|CDD\|178997	PRK00391, rpsR, 30S ribosomal protein S18; Reviewed.	3.09896e-39
NC_015947.1\|WP_014037722.1\|2847187_2848276_-\|DUF1311-domain-containing-protein	gnl\|CDD\|377758	pfam07007, LprI, Lysozyme inhibitor LprI. This family consists of several bacterial proteins of around 120 residues in length. Members of this family contain four highly conserved cysteine residues. Family members include lipoprotein LprI from Mycobacterium, which binds to and inhibits macrophage lysozyme, which may aid bacterial survival.	1.66473e-11
NC_015947.1\|WP_014037732.1\|2862018_2862756_-\|cell-division-protein-ZipA	gnl\|CDD\|235308	PRK04570, PRK04570, cell division protein ZipA; Provisional.	8.92065e-160
NC_015947.1\|WP_014037723.1\|2848401_2850930_-\|membrane-bound-PQQ-dependent-dehydrogenase,-glucose/quinate/shikimate-family	gnl\|CDD\|274418	TIGR03074, PQQ_membr_DH, membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family. This protein family has a phylogenetic distribution very similar to that coenzyme PQQ biosynthesis enzymes, as shown by partial phylogenetic profiling. Members of this family have several predicted transmembrane helices in the N-terminal region, and include the quinoprotein glucose dehydrogenase (EC 1.1.5.2) of Escherichia coli and the quinate/shikimate dehydrogenase of Acinetobacter sp. ADP1 (EC 1.1.99.25). Sequences closely related except for the absense of the N-terminal hydrophobic region, scoring in the gray zone between the trusted and noise cutoffs, include PQQ-dependent glycerol (EC 1.1.99.22) and and other polyol (sugar alcohol) dehydrogenases.	0
NC_015947.1\|WP_006452997.1\|2867362_2867800_-\|30S-ribosomal-protein-S6	gnl\|CDD\|179034	PRK00453, rpsF, 30S ribosomal protein S6; Reviewed.	2.66568e-50
NC_015947.1\|WP_014037731.1\|2861384_2861831_+\|hypothetical-protein	gnl\|CDD\|224854	COG1943, COG1943, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	3.87055e-09
NC_015947.1\|WP_014037730.1\|2860134_2861259_+\|pyridoxal-phosphate-dependent-aminotransferase	gnl\|CDD\|181651	PRK09105, PRK09105, pyridoxal phosphate-dependent aminotransferase.	0
NC_015947.1\|WP_014037724.1\|2851061_2853782_-\|DNA-gyrase-subunit-A	gnl\|CDD\|235502	PRK05560, PRK05560, DNA gyrase subunit A; Validated.	0
NC_015947.1\|WP_014037734.1\|2866565_2867015_-\|50S-ribosomal-protein-L9	gnl\|CDD\|234659	PRK00137, rplI, 50S ribosomal protein L9; Reviewed.	2.8393e-66
NC_015947.1\|WP_014037729.1\|2857466_2859932_-\|NAD-dependent-DNA-ligase-LigA	gnl\|CDD\|236137	PRK07956, ligA, NAD-dependent DNA ligase LigA; Validated.	0
NC_015947.1\|WP_006452998.1\|2868658_2868997_-\|iron-sulfur-cluster-assembly-accessory-protein	gnl\|CDD\|223393	COG0316, sufA, Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones].	1.23115e-42
NC_015947.1\|WP_014037735.1\|2868021_2868564_-\|CbrC-family-protein	gnl\|CDD\|367610	pfam03691, UPF0167, Uncharacterized protein family (UPF0167). The proteins in this family are about 200 amino acids long and each contain 3 CXXC motifs.	1.21298e-58
NC_015947.1\|WP_014037733.1\|2862802_2866306_-\|chromosome-segregation-protein-SMC	gnl\|CDD\|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0
NC_015947.1\|WP_014037736.1\|2869125_2870520_+\|asparagine--tRNA-ligase	gnl\|CDD\|235176	PRK03932, asnC, asparaginyl-tRNA synthetase; Validated.	0
NC_015947.1\|WP_014037725.1\|2853999_2855064_-\|S-methyl-5-thioribose-1-phosphate-isomerase	gnl\|CDD\|235578	PRK05720, mtnA, methylthioribose-1-phosphate isomerase; Reviewed.	0
NC_015947.1\|WP_014037727.1\|2855978_2856935_-\|EF-P-lysine-aminoacylase-GenX	gnl\|CDD\|273090	TIGR00462, genX, EF-P lysine aminoacylase GenX. Many Gram-negative bacteria have a protein closely homologous to the C-terminal region of lysyl-tRNA synthetase (LysS). Multiple sequence alignment of these proteins with the homologous regions of collected LysS proteins shows that these proteins form a distinct set rather than just similar truncations of LysS. The protein is termed GenX after its designation in E. coli. Interestingly, genX often is located near a homolog of lysine-2,3-aminomutase. Its function is unknown. [Unknown function, General].	1.9851e-140

>NC_015947.1|WP_014037731.1|2861384_2861831_+|hypothetical-protein
MPSPRLLRGRWSQLRNVYAITTVTHQRHRHFDDPHQAAVVVAGLQWIQQEGRCLNLAWAVMPDHVHWLMQLRSGTLAASVQMMKSRCSRLIGIDGPLWQRGYHDHAVRCDESLRNQALYIAANPVRAGLAAQLGDHPFAWCRWLDRSP
>NC_015947.1|WP_014037730.1|2860134_2861259_+|pyridoxal-phosphate-dependent-aminotransferase
MTLPASRRRFLQLAGAGLAVASSGLPQLGQAQPAAAVAAPPAEGAVLLNFNECPYGPSPAAQQAARDSIASCGRYRFALAAQVRDAFIEQARIPADHVRLYPGSSEPLNRAATLWTGPQAGLVVADPTFETLGEVAAAHGAHVQKVPLRDDGAHDLRAMVAAAHARPTGLLYVCNPNNPTGSVSPPDELAWLLAHKPASTRVLVDEAYLQYSEQPSLIEQVTQRDDLIVLRTFSKLYGMAGLRLGVAAAHPERLRELASLGDNPLPVPALAAALASLHDPQLIPQRRLQNARVRQATIAWLGKRGFSCLPSEANCFVVDVQRDGAAFAKAMADNGVVIGRSWPIWPQRVRVTVGSEDEMAAFRNAFAKVAGVPA
>NC_015947.1|WP_014037729.1|2857466_2859932_-|NAD-dependent-DNA-ligase-LigA
MSPSPAERAEDLRRQIAQANRAYHELDAPEIPDVDYDRMVRELEALEREHPELARADSPTQQVGARPSGRFPEVRHAVPMLSLSNAFSDEEVADFVRRIDERLGRRSLRFSAEPKMDGLAISLRYEDGHFALGATRGDGSTGEDVTANLREIGDVPKRLHGKDWPDVLEVRGEVYMARADFEAYNERARQQGGKVLANPRNAAAGSLRQLDPKISAQRRLSFFAYGTGEVQGGELPDTHSGTLAQLGAWGFPVSELCKVVEGTDGLLGYYRDIGERRDGLPFDIDGVVYKLDDRAGQQAMGFVSRAPRWAIAHKFPAQEQSTTVEAIEIQIGRTGAATPVARLAPVAVAGVIVSNATLHNADQIARLDVRVGDSVIVRRAGDVIPEVVSVILDRRPQGTTPWQMPTRCPVCGSEIVREEGAAAWRCSGELSCPAQRKEAIAHFASRRAMDIDGLGDKYIETLVDAGIVRSVADLYRLNRDQLLHLKLVLDAEDPSALAAALKLHLPAEGSGAVLNAVLKLDGNDPAWRAQALAQPASFEWNTKKIATKWADNLIAAIDASRAATLERLLFALGIEHVGESTAKALAQWFGDLELIRHLPWPLFKRVPDIGGEVARSLGHFFEQQGNQQAIDDLLQVGQVRISDVHAPSAKLREGLDLAQLLVESEIPGITRLRAEKLVAALPGAQAVLDAEHGQFVNAGLPDDTARGLVEWLDADGHGAMLLAAEKAMQQILAKAPALAEIVAGPLDGQTVVLTGTLAQLTRDAAKERLEALGAKVSGSVSKKTSFVVAGTEAGSKLDKAQSLGVPVWDEDRLLAYLAEHE
>NC_015947.1|WP_014037728.1|2856931_2857417_-|GNAT-family-N-acetyltransferase
MQTAPLDFRLATRADEELLIELMREFYAEDRIDFDDARVRRGVDALLADPRNGEVLLWLDEAGEVVGYAVIAMGFSLEQGGHFMLLDELYLSHRARGRGRGKQALAICEQRARGRGVSRLRLEVNHHNELARRLYLASGYIDDTRDLLTLPLDHPRPEGIL
>NC_015947.1|WP_014037727.1|2855978_2856935_-|EF-P-lysine-aminoacylase-GenX
MSEALLRALQQRAALNALVRRFFAERDVLEVETPILSVAGNTEPNIDSFHTDFTGHVDAGGRRRWLRTSPEYPLKRLLAAGVGDCYELGRVFRNGEAGGRHNPEFTMLEWYRVGWDHHRLVQETAELVGQALALVGRRATLRVLSYRELFQQHVGVDPFEADEAALRVALGDVRIDPVGLTRDDWLDLLMTHHIQPQFDDGVMTVVHDWPASQAALARIRAGTPPLAERFELYLGAVELANGYHELNDAHEQRARFQRDQQRRHERGQVQPALDEALLAALPSMPACAGVAVGVDRLLMAMNRTRRIADVLAYDFAHA
>NC_015947.1|WP_014037726.1|2855111_2855840_-|DUF3011-domain-containing-protein
MVKWFAVVAAPVYSIALWGAWLPSPASAQQVGYDDEVVTCESRDMGWVHCDIEVANGVDLVRQLSSNSCIRGSEWGTDRSGVWVTLGCRAEFRARRAAGAAPAANESKRLVRRVVRCESNGRPQSCPVRLDGAPVRLLRQLSVLPCREGQGWGYKRNEVWTSRGCQGDFEVADDDGRFVDMPRRLTCESKSKKRRFCGASISVGAVVSEQLSSTPCEEGSTWGWNRNGIWVDGGCRAEFSVN
>NC_015947.1|WP_014037725.1|2853999_2855064_-|S-methyl-5-thioribose-1-phosphate-isomerase
MNTAPDIDYARYDHIRPILWTGDALQLLDQRKLPFVVEHVVCHDSDEVASAIHALTVRGAPAIGIAAAWGVVLAARAVQAVDGAHALQQLEPALQRLNASRPTAVNLAWALARMRRCLNAAGADWKALLESEAQAIAEEDLAANRHMGALGAGLIDAGSGVLTHCNTGSLATAGFGTALGVIRAGMAQHRIARVFAGETRPWLQGARLTVWELQQDGIDATLIADSAASHLMKTGAVQWVIVGADRICANGDTANKIGTYQLAIAARHHGVRFMVVAPSSTVDMETVDGSQIEIEQRDPGELYGVGGTRTVAEGIAAWNPVFDVTPGELIDAIVTERGVILNPTAENMRAAFGG
>NC_015947.1|WP_014037724.1|2851061_2853782_-|DNA-gyrase-subunit-A
MAETAKEIIQVNLEDEMRKSYLDYAMSVIVGRALPDARDGLKPVHRRVLYAMNELNAHSNKPYFKSARIVGDVIGKYHPHGDQSVYDTLVRLAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEARMSRLAHELMADIDKETVDFQPNYDEKELEPTVMPTRFPNLLVNGSAGIAVGMATNIPPHNLSESINACIALIDNPDIDVDGLMEYIPGPDFPTAGIINGTAGIVAGYRTGRGRVRIRAKADIEVADNGRESIIVTEIPYQVNKARLIEKIAELVKEKKIEGISELRDESDKDGMRIYIEIKRGESAEVVLNNLYQQTQMESVFGINMVALVDGRPQLMNLKQMLEAFVRHRREVVTRRTVFELRKARARAHVLEGLTVALANIDEMIELIKTSPNPNEARERMLARVWEPGLVGAMLGAAGAEASRPEDLPKGVGLIEGGYQLTEIQATQILEMRLHRLTGLEQDRLTDEYKQLLEVIAGLIHILEDPDRLLQVIREELVNVKAEFGDERRTEIRHSEEDLDILDLIAPEDVVVTVSHAGYVKRQPVSVYRAQRRGGRGRSAAATKEEDFIEQLWLVNTHDTLLTFTSSGKVFWLPVYQLPEAGSNARGRPIINWIPLEPGERVQAVLPVREYADGQFVFFATKNGTVKKTPLSEFAFRLARGKIAINLDEGDALVGVGLTDGERDILLFASNGKTVRFGEDKVRSMGRTATGVRGIKMPAGEEVVSLIVAESAGGIEDENEDDNGVEEAVANGDAVIDGADDASVQYILTATENGYGKRTPLPDYPRKGRGTQGVIGIQTTERNGKLVAAVLMGSGDEVLLISDGGTLVRTRGSEISRVGRNTQGVTLIRLSKDEKLQAVERMDASIDEDEDEVAVAAPATTTTDGAPAAASSEDAAQE
>NC_015947.1|WP_014037723.1|2848401_2850930_-|membrane-bound-PQQ-dependent-dehydrogenase,-glucose/quinate/shikimate-family
MSATPPSAPAPVRAFRHPLVTVLSLLLVVLGLVIGGLGAWLLRLGGSAYYAIAGAGLLASGILLFGNRRSGALLYALVFIGTLLWTWWESGSDYWRWVPRLGLVTALGIVLALLAPTLHQPVSRRLSRSVAGVLMLVFVAAFGLAFAPHGEVDGHQPFPEGAASAGLEPTRDTTGLQPADQPAEGDWPAWGRSNAATRYSPLQQITPANVATLQPAWQFRTGDMPKKRWGAETTPLKIGDRLYLCTARNRLIALDAASGKEVWRFDPKVKDASIPYTAACRGVSYYEQPATPTFADVALADVAADLALPEPPPSATPSAAPGSRPACWARIIEGTLDGRIIAVDADSGRPCANFGNNGQVDITLGMGEVPPGYVSITSPPAIVRGVIVTGHQVLDGQRRDAPSGVIQAYDAITGKLRWAWDMDQPERSGLPPHEQTYTRGTPNMWTTATGDEALGLVYLPLGNSAGDYWSGSRTENQNRYATSLVAIDVTTGKPAWHFQAVRKDVWDYDLGSQASLIDYPTAAGKVPALLLPTKQGDLYILDRRNGQLLTAAEERKVPVGGVEPEQRSPTQLFSLYHTLRREHDLTERDMWGITPIDQLICRIQFRKAYYEGFYTPPSSDRHSIEYPGYNGGSDWGSVSIDTRRGVIVANYNDMPNYNRLVPRAEADRLGWLPREKIRFDKGGAEGAGDPQVGTPYAIQVNAGWRLPFTGLLCKQPPYGGIRAIDLRTGKLLWDRPFGSARGNGPFGIRSGLPIEIGTPNNGGSVVTASGLIFIAAATDDLLRAIDLKTGRELWHATLPAGGQATPMVYAQGGRQYVVIMAGGHHFMETPNGDYVMAFALPK
>NC_015947.1|WP_014037722.1|2847187_2848276_-|DUF1311-domain-containing-protein
MLNSERLPGCVTRLLAGLLLLGPCLGASAQTSPQPAVRKVPSGAELIAGDARYLSPAHAPCMAAAGNALDAQRRCADAEFKVHDDALNAAYRAARSALTASDQQVLRDLQRQWLRQRDSRCPEGGTAVAQLDAQQCRTHMTLLRARQLQGGGVAALVAEAKAAPAPAQAAVHTADAAPDKQGRIILRPGEGRITPALQVVFQVADCSGTDNVTTCRVRSMSVTRGGRNVAVTGVQPRLTRAGADAQGAAAVLLTASDFNGDGVPDLQVWQDNNGVYNVPVHAFYLFDAKGNRYVRAKALEAAIGGRDIDHIDNGRFVLRAKVSPCEREDKVIQLRGTEPRTLLQRRYDTCRGEAPTESDLLK
>NC_015947.1|WP_014037732.1|2862018_2862756_-|cell-division-protein-ZipA
MSDTALLRIGILAAGLLLIAAIFLFGRPKKKPQGRRVDSAEPTSGERREPVLGEDGVVVADGRVEPGMGAEGEQAELGLADTDPGASDLGKRATQDFDKIVSLFVAARAGEQLRGEDIVVAAEKTGLVFGHMNVFHRLVEGHPERGPIFSMASIMKPGSFDMANIRAMETPAIAFFLTLPAPLTALDAWEKMLPTVQRMAELLDGVVLDDSRNALGRQRIAHIRDELRAYDRQHQAPPLTKTPRW
>NC_015947.1|WP_014037733.1|2862802_2866306_-|chromosome-segregation-protein-SMC
MRLSTIKLSGFKSFVDPTTLHLPTNMTGVVGPNGCGKSNIIDAVRWVMGESSASRLRGDSLTDVIFSGSNARKPVSQATVELIFDNSDHTISGEYASFNEISVKRTVSRDGTSNYYLNGTKCRRRDITDLFLGTGLGPRSYSIIEQGMISQIIEARPEDLRVYLEEAAGISKYKERRKETETRIRHTRENLDRLGDLRDEISKQLEHLKRQAKQAEQYQALQEERRVKDAEWKALEFRGLDGRLSKLREGLSQEETKLQQLIADQRDAEARIETSRVRREEAADALNTAQAAVYQVGSTLARLEQQIQHQRELSQRLHKARDETRQALAELGQHISGDEAKLMVLREAVEAATPQLEELQEENEIKQESLREAEDRLASWQQRWEQHTSQSSEASRAGDVERTRVDYLDKQILDADRRREALAAERAGLDVGALEEAFEQLHLQHDTQKTALDELSEDVELRKQGVAEVQEQQRNGQNELAELRKQANGLRGRLASLETLQQAALGQEQGAAVAWLKARGLDSAARVGERLDVDAGWENAVESALGQLIEGVLVDDPGSLVDALGELGDGHIALVASAGADVKAAPTSLAARVRGPAAIRRLLAHLHAAKDLSEAKALQASLPEGDSIITQSGERLGQGWLRVSRSGAAQQGALLREREINELREQIEQLQDREAELEEQLSGFREQLQAAEQQREDAQRALYQAHRAVSELAGQLQGQQGKVEAARTRIDRIEGELKQLQETLEANNEQAREARSRLENAVSSMGDLESTRQRLEGERRQLTEARDLARDAARAVRERSHSLALTLESQRAQLASLSQALERMGTQRGQLDSRLGELHSQLDEGDSPVESLQAEHQNALEERVRADRVLTEARTLLDGIDAELRNYEQTRHQRDEQALAQRERISQRKLDQQALVLSADTLQGAVEKAGFVLQDVLNALPEDARLGDWEQAVHQIDGRMRRLEPVNLAAIHEYGEASQRSDYLDSQHTDLTTALETLEDAIRKIDRETRGRFKDTFDRVNAGVQALYPRLFGGGHAYLELTGEDLLDTGVTIMARPPGKRVSSISLLSGGEKAMTAVALVFAIFQLNPAPFCLLDEVDAPLDEANVGRLANMVKEMSEKVQFLFVSHNKATMEAAHQLSGVTMREPGVSRLVSVDLEEAARLAGAA
>NC_015947.1|WP_014037734.1|2866565_2867015_-|50S-ribosomal-protein-L9
MQLILLQKVTNLGNLGDLVDVKPGYGRNFLVPQGKAVPATESNKAEFEAKRAEYEAKAQAIHADADARKAKLEGASVTIPANASTEGKLYGSVGAREIADAFTAAGLPVSKSEVILGEGAFRNIGEYDVLVHLHADVETTVKVVVVAEA
>NC_015947.1|WP_002804494.1|2867120_2867351_-|30S-ribosomal-protein-S18
MSKFFRRRKFCKFTAEGVKEIDYKDLNTLRQYLTENGKIVPSRVTGTKSKYQRQLATAVKRARFLALIPYTDNHDV
>NC_015947.1|WP_006452997.1|2867362_2867800_-|30S-ribosomal-protein-S6
MSRHYEIVFMVHPDQSEQVPAMIERYKSLVENGNGTIHRLEDWGRRQLAYPIQNLVKAHYVLMNIEADQAVLNELTESFRFNDAVLRNLVIKRDEADTEQSLIMKSKDEKGDKPERGERRRRDDEEGESTTTADNEAGDDAASAA
>NC_015947.1|WP_014037735.1|2868021_2868564_-|CbrC-family-protein
MERPAFIYHPNAYALSFEEVDGVCDCCGQPRTLRYRGPFYTRLRPEYLCPWCIADGRAAASYEGEFTGWSDIEGVSPDPADPPPTIARELLLEICERTPGYSSWQQSVWLSHCERPCAFLGYAGSDDLLPILDQVRPDVVEINPRDADWVLEHLSRDGMMVGCLFQCLECGQHRLHVDLG
>NC_015947.1|WP_006452998.1|2868658_2868997_-|iron-sulfur-cluster-assembly-accessory-protein
MAVSLTPIAFERVQRFVAQTPGALGLRFGVTKTGCSGWGHVTDLARDEREGDTVFDQDGVKIYVDAKSLALVDGTVIDFGKHGLSETFTFSNPNATAECGCGESFTTDADKA
>NC_015947.1|WP_014037736.1|2869125_2870520_+|asparagine--tRNA-ligase
MTVVSVEHALAGKIPEGGEVTVRGWVRTVRGSANLAFVNVSDGSCFAPIQVVAGDSLANFDEIKRLTSGCSVIATGTLVKSQGKGQSFEIQASALEVVGWVEDPLTYPIQPKPMSPEFLREVAHLRPRTNLFGAVTRIRNCLAQAVHRFFHENGFNWISTPIITTSDAEGAGQMFRVSTLDMVNLPRDEKGAIDFSRDFFGKETFLTVSGQLNVEAYCLALSKVYTFGPTFRAENSHTTRHLAEFWMIEPEIAFADLAEDARLAEEFLKYLFRAVLNERGDDLAFIAERVDKNAITKLEDFINAPFERIDYTDAVSLLQKSGKKFDFPVEWGLDLQTEHERWLTEEHVGRPVVVTNYPEHIKAFYMRLNDDGRTVAAMDVLAPGIGEIIGGSQREERLDVLDARMAQFGLDREHYSWYRDFRRYGSVPHAGFGLGFERLVVYVCGLSNIRDAIPYPRAPGSADF
>NC_015947.1|WP_014037737.1|2870550_2870850_+|hypothetical-protein
MTLFFALCFVGVAVAGFSAFVIFWPLTLVHVRDRHPALAERFGSGAFLKPDALAWLLRRDYRQQPDRSLSGLATPAWVSLLTLLTGLGMAALLWLASLW
>NC_015947.1|WP_014037738.1|2870857_2871172_+|hypothetical-protein
MNDISASRDSWWLASLGNTLIWARLRVRPAGTAEVLDSDGNTLSYDSEDTARSQLFDAEFVEYDGLDEEDALVRGFSLHEVQPPQADSDEGLRGRMIQSLGGRA

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Crispr_ID: NC_015947_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015947_8

2952451-2952557

Orphan

Consensus_repeat	Method
CATCCACGCACGGCGTGGATCTAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015947_8

>merge|NC_015947|8|2952451-2952557|CRISPRCasFinder
CATCCACGCACGGCGTGGATCTACGGGTGGGTGCCGACCGTTGGTCGGCACGATCCTTCCGGGCCATGAACCCCGGTATCGTCCATCCACGCATGGCGTGGATCTAC

>NC_015947|8|8|2952451-2952557|CRISPRCasFinder
CATCCACGCACGGCGTGGATCTAC	GGGTGGGTGCCGACCGTTGGTCGGCACGATCCTTCCGGGCCATGAACCCCGGTATCGTC
CATCCACGCATGGCGTGGATCTAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015947.1\|WP_014037799.1\|2946146_2946596_+\|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|225039
NC_015947.1\|WP_005417588.1\|2954617_2954920_-\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|379642
NC_015947.1\|WP_014037809.1\|2957696_2958545_+\|endonuclease/exonuclease/phosphatase-family-protein	unknown	unknown	gnl\|CDD\|377028
NC_015947.1\|WP_014037802.1\|2949609_2950089_-\|glutathione-peroxidase	unknown	unknown	gnl\|CDD\|223463
NC_015947.1\|WP_014037805.1\|2953698_2954580_-\|DUF3298-and-DUF4163-domain-containing-protein	unknown	unknown	gnl\|CDD\|379356
NC_015947.1\|WP_014037800.1\|2946834_2948706_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_015947.1\|WP_014037797.1\|2943077_2943416_-\|hypothetical-protein	unknown	unknown	unknown
NC_015947.1\|WP_014037795.1\|2941970_2942312_+\|arsenate-reductase-(glutaredoxin)	unknown	unknown	gnl\|CDD\|239332
NC_015947.1\|WP_014037808.1\|2955968_2957534_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340905
NC_015947.1\|WP_014037798.1\|2945213_2946110_+\|RNA-polymerase-sigma-70-factor	unknown	unknown	gnl\|CDD\|132002
NC_015947.1\|WP_005410310.1\|2958677_2959289_-\|superoxide-dismutase	unknown	unknown	gnl\|CDD\|223678
NC_015947.1\|WP_014037811.1\|2959960_2960374_+\|barnase-inhibitor	unknown	unknown	gnl\|CDD\|240164
NC_015947.1\|WP_014037812.1\|2960518_2962279_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NC_015947.1\|WP_014037796.1\|2942383_2943019_-\|glutathione-S-transferase-family-protein	unknown	unknown	gnl\|CDD\|223698
NC_015947.1\|WP_014037801.1\|2948786_2949566_+\|ferredoxin--NADP-reductase	unknown	unknown	gnl\|CDD\|99792
NC_015947.1\|WP_014037807.1\|2955334_2955961_-\|rhomboid-family-intramembrane-serine-protease	unknown	unknown	gnl\|CDD\|223777
NC_015947.1\|WP_014037804.1\|2952563_2953679_-\|cyclopropane-fatty-acyl-phospholipid-synthase	unknown	unknown	gnl\|CDD\|183282
NC_015947.1\|WP_042358840.1\|2950219_2952388_+\|M3-family-metallopeptidase	unknown	unknown	gnl\|CDD\|341051
NC_015947.1\|WP_008268808.1\|2943540_2945058_-\|fumarate-hydratase	unknown	unknown	gnl\|CDD\|224862
NC_015947.1\|WP_014037810.1\|2959508_2959961_+\|ribonuclease	unknown	unknown	gnl\|CDD\|238340

Protein	Function_ID	Function_description	E-value
NC_015947.1\|WP_014037799.1\|2946146_2946596_+\|carboxymuconolactone-decarboxylase-family-protein	gnl\|CDD\|225039	COG2128, COG2128, Uncharacterized conserved protein [Function unknown].	1.23306e-28
NC_015947.1\|WP_005417588.1\|2954617_2954920_-\|N-acetyltransferase	gnl\|CDD\|379642	pfam14542, Acetyltransf_CG, GCN5-related N-acetyl-transferase. This family of GCN5-related N-acetyl-transferases bind both CoA and acetyl-CoA. They are characterized by highly conserved glycine, a cysteine residue in the acetyl-CoA binding site near the acetyl group, their small size compared with other GNATs and a lack of of an obvious substrate-binding site. It is proposed that they transfer an acetyl group from acetyl-CoA to one or more unidentified aliphatic amines via an acetyl (cysteine) enzyme intermediate. The substrate might be another macromolecule.	2.58052e-26
NC_015947.1\|WP_014037809.1\|2957696_2958545_+\|endonuclease/exonuclease/phosphatase-family-protein	gnl\|CDD\|377028	pfam03372, Exo_endo_phos, Endonuclease/Exonuclease/phosphatase family. This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling. This family includes: AP endonuclease proteins EC:4.2.99.18, DNase I proteins EC:3.1.21.1, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56, Sphingomyelinase EC:3.1.4.12, and Nocturnin.	2.93643e-08
NC_015947.1\|WP_014037802.1\|2949609_2950089_-\|glutathione-peroxidase	gnl\|CDD\|223463	COG0386, BtuE, Glutathione peroxidase [Posttranslational modification, protein turnover, chaperones].	8.73726e-92
NC_015947.1\|WP_014037805.1\|2953698_2954580_-\|DUF3298-and-DUF4163-domain-containing-protein	gnl\|CDD\|379356	pfam13739, DUF4163, Domain of unknown function (DUF4163). The structure of this domain is and alpha-beta-two layer sandwich, identified from a Fervidobacterium nodosum Rt17-B1 like protein. The function is not known except that it is found in association with Heat-shock cognate 70kd protein 44kd ATPase, pfam11738.	4.42385e-08
NC_015947.1\|WP_014037800.1\|2946834_2948706_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	5.98911e-102
NC_015947.1\|WP_005410310.1\|2958677_2959289_-\|superoxide-dismutase	gnl\|CDD\|223678	COG0605, SodA, Superoxide dismutase [Inorganic ion transport and metabolism].	2.19761e-109
NC_015947.1\|WP_014037795.1\|2941970_2942312_+\|arsenate-reductase-(glutaredoxin)	gnl\|CDD\|239332	cd03034, ArsC_ArsC, Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the detoxification of arsenic, using reducing equivalents derived from glutathione (GSH) via glutaredoxin (GRX). ArsC contains a single catalytic cysteine, within a thioredoxin fold, that forms a covalent thiolate-As(V) intermediate, which is reduced by GRX through a mixed GSH-arsenate intermediate. This family of predominantly bacterial enzymes is unrelated to two other families of arsenate reductases which show similarity to low-molecular-weight acid phosphatases and phosphotyrosyl phosphatases.	8.63312e-50
NC_015947.1\|WP_014037808.1\|2955968_2957534_-\|MFS-transporter	gnl\|CDD\|340905	cd17347, MFS_SLC15A1_2_like, Solute carrier family 15 members 1 and 2, and similar Major Facilitator Superfamily transporters. Solute carrier family 15 member 1 (SLC15A1) and SLC15A2 are members of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. They mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A1, or peptide transporter 1 (PepT1), is primarily expressed in the brush border membranes of enterocytes of the small intestine and is also known as the intestinal isoform. SLC15A2, or peptide transporter 2 (PepT2), is abundantly expressed in the apical membrane of kidney proximal tubules and is also referred to as the renal isoform. Both proteins transport di/tripeptides, but not tetrapeptides or free amino acids, using the energy generated by an inwardly directed transmembrane proton gradient. The SLC15A1/SLC15A2-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.43367e-76
NC_015947.1\|WP_014037798.1\|2945213_2946110_+\|RNA-polymerase-sigma-70-factor	gnl\|CDD\|132002	TIGR02957, putative_sigma_factor, RNA polymerase sigma-70 factor, TIGR02957 family. This group of sigma factors are members of the sigma-70 family (TIGR02937). They and appear by homology, tree building and bidirectional best hits, to represent a conserved family. This family is found in a limited number of bacterial lineages. This family includes apparent paralogous expansion in Streptomyces coelicolor A3(2), and multiple copies in Mycobacterium smegmatis MC2, Streptomyces avermitilis MA-4680 and Nocardia farcinica IFM10152.	2.1116e-111
NC_015947.1\|WP_014037811.1\|2959960_2960374_+\|barnase-inhibitor	gnl\|CDD\|240164	cd05141, Barstar_evA4336-like, Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell. Barstar also binds and inhibits a ribonuclease called RNase Sa (produced by Streptomyces aureofaciens) which belongs to the same enzyme family as does barnase.	3.84213e-25
NC_015947.1\|WP_014037812.1\|2960518_2962279_-\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	9.11533e-14
NC_015947.1\|WP_014037796.1\|2942383_2943019_-\|glutathione-S-transferase-family-protein	gnl\|CDD\|223698	COG0625, Gst, Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones].	4.06804e-38
NC_015947.1\|WP_014037801.1\|2948786_2949566_+\|ferredoxin--NADP-reductase	gnl\|CDD\|99792	cd06195, FNR1, Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently bound FAD as a prosthetic group) are present in chloroplasts, mitochondria, and bacteria in which they participate in a wide variety of redox metabolic pathways. The C-terminal domain contains most of the NADP(H) binding residues and the N-terminal domain interacts non-covalently with the isoalloxazine rings of the flavin molecule which lies largely in a large gap betweed the two domains. Ferredoxin-NADP+ reductase first accepts one electron from reduced ferredoxin to form a flavin semiquinone intermediate. The enzyme then accepts a second electron to form FADH2 which then transfers two electrons and a proton to NADP+ to form NADPH.	8.78639e-116
NC_015947.1\|WP_014037807.1\|2955334_2955961_-\|rhomboid-family-intramembrane-serine-protease	gnl\|CDD\|223777	COG0705, COG0705, Membrane associated serine protease [Amino acid transport and metabolism].	5.19101e-16
NC_015947.1\|WP_014037804.1\|2952563_2953679_-\|cyclopropane-fatty-acyl-phospholipid-synthase	gnl\|CDD\|183282	PRK11705, PRK11705, cyclopropane fatty acyl phospholipid synthase.	0
NC_015947.1\|WP_042358840.1\|2950219_2952388_+\|M3-family-metallopeptidase	gnl\|CDD\|341051	cd06456, M3A_DCP, Peptidase family M3, dipeptidyl carboxypeptidase (DCP). Peptidase family M3 dipeptidyl carboxypeptidase (DCP; Dcp II; peptidyl dipeptidase; EC 3.4.15.5). This metal-binding M3A family also includes oligopeptidase A (OpdA; EC 3.4.24.70). DCP cleaves dipeptides off the C-termini of various peptides and proteins, the smallest substrate being N-blocked tripeptides and unblocked tetrapeptides. DCP from Escherichia coli is inhibited by the anti-hypertensive drug captopril, an inhibitor of the mammalian angiotensin converting enzyme (ACE, also called peptidyl dipeptidase A). OpdA may play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. It can also cleave N-acetyl-L-Ala. This family also includes Arabidopsis thaliana organellar oligopeptidase OOP (At5g65620), which plays a role in targeting peptide degradation in mitochondria and chloroplasts; it degrades peptide substrates that are between 8 to 23 amino acid residues, and shows a weak preference for hydrophobic residues (F/L) at the P1 position.	0
NC_015947.1\|WP_008268808.1\|2943540_2945058_-\|fumarate-hydratase	gnl\|CDD\|224862	COG1951, TtdA, Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion].	1.36593e-145
NC_015947.1\|WP_014037810.1\|2959508_2959961_+\|ribonuclease	gnl\|CDD\|238340	cd00607, RNase_Sa, RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate specific endoribonuclease which belongs to the superfamily of microbial ribonucleases. Typical of this sub-family, the enzyme hydrolyses the phosphodiester bonds of RNA at the 3' oxygen end of guanosine residues to yield oligonucleotides with the guanosine-2',3'-cyclophosphate at the 3' end and the hydroxyl group at the 5' end. The terminal guanosine-2,3'-cyclophosphate is hydrolysed by guanyl RNAses to give guanosine-3'-phosphate.	6.6472e-43

>NC_015947.1|WP_042358840.1|2950219_2952388_+|M3-family-metallopeptidase
MTTRLALAVAMSLGLALPAFSAGAATPAASTTAQQANPFFAESPLPLHFPQFDKIKDSDFAPAFDAGMAQQLKEVEAIANNKAKPTFDNTIIALEKSGDILDRATTVFFSLVGADTNDTRKKLQADYSAKFAAHSDAIALNGKLFARIQALYDTRSQLGLDAEGVRLVEKYYDNYVRAGAKLSEADKATLKAMNAELANLGTKFSQNVQSEVNASAITVDDVKELAGLSKEQIAAAAEAAKARGLEGKYVITLLNTTGQPPLTNLANRALRQKIYEASTTRGSRGGEFDNTALVSRIMQLRADKAKLMGFPNFAAYNLTNQTAKTPEAVNAMLGKLAPAAVANAKREAADLQAMIDKEQKAARKPTFQLEPWDWAFYSEKVRQAKYNFDESQLKPYFELKNVLENGVFYAAGQEFGLTFKQRTDLPVYHDDVTVYDVFDADGSQLAIFIFDPYARASKRGGAWMNSYVSQSKLTGFKPVVANHLNIPKPPAGQPTLLTWDEVNTTFHEFGHALHGMFSNVKYPYFSGTSVPRDFVEFPSQVNEMWSDNPVILKNYAKHYQNGSAMPQALLDKVIAASKFNQGFATTEYLGAAMLDQNWHQIGPDQVPAAKDVMAFERAALEKDGIYYAPVPPRYKTPYFSHIMGGYSAGYYAYIWSEVLDANTQKWFKDNGGLSRKNGDHFRATLLSKGGSVDAMQLFRDFAGHEPQIEPLLEKRGLTGAGN
>NC_015947.1|WP_014037802.1|2949609_2950089_-|glutathione-peroxidase
MTTAYDFSFRDLDGQPQALARYQGHPLLLVNVASRCGFTPQYTGLEQLWQEYRERGLVVIGFPCNQFGAQEPGDAAQIRQFCSLDYPVSFPLSEKIEVNGEGADPLWAWLAREKRGLLGSARIKWNFSKFLVDRQGRVASRHAPTTRPEQLRGEIEALL
>NC_015947.1|WP_014037801.1|2948786_2949566_+|ferredoxin--NADP-reductase
MSSAFGAETVLEVRHWTDAYFSFTLTRDSGFRFENGQFVMIGLETEARPLLRAYSIASANWEEHLEFFSIKVQDGPLTSRLQHIKPGDKVLVGKKPTGTLLISDLHPGKNLYLLGTGTGMAPWLSVIKDPETYERFEKVILCHGVRYEKDLAYRDYFEKELREHEFLGEMIGDKLLYYPAVTREPFANQGRLTSLMESGEMQRTLGLPELSPENDRAMICGSPQMLADLRAVLDARGFQVSPRIGQPGHYVFERAFVEK
>NC_015947.1|WP_014037800.1|2946834_2948706_+|ABC-transporter-ATP-binding-protein
MPASPTAGAAAAKKPSLRQRFRAMRNLPPFLRMVWQTSPALTLASLGLRLIRALLPVAMLYVGKLIIDSALHLSQHDAGFPPLGEALSSGVLNPLLGLLALEFGLAIASDLLGRLVSYADALLSELFANVTSIRLMEHAATLDLEDFEDPDLQDKLDRARRQTMGRMNLMSQLFGQVQDAITVASLAVGLLVYAPWLILLLALALVPAFIGESHFNAAGYSLNFQWTPERRQLDYLRQLGASVETAKEVKIYNLHRFLVERYRRLSVALFQANRALARRRAFWGTLLAALGTLGYYTAYAYIAWRTVRGDFSIGDLTFLAGSFLRLRQLLEGLLIGFSQVASQALYLDDLFSFFQIQPEIHSREGAARVPQPIRQGFVFENVGFRYPDAEQWAVRHLDFQLQAGEVLALVGENGAGKTTLVKLLARLYEPDEGRILLDGRDLRDYDLDDLRANLGVIFQDFVRYNLSAGENIGVGQVEAMDDQARIADAARRGMAEEVIDDLPGGYDQLIGRRFKQGVDLSGGQWQKIAIARAWMRNAQVMILDEPTAALDARSEFEVFQRFRELADNRTAVLISHRFSSVRMADRILVLADGRIEASGTHEQLMAQGGRYAELFELQAAGYR
>NC_015947.1|WP_014037799.1|2946146_2946596_+|carboxymuconolactone-decarboxylase-family-protein
MSDHASPRVPYTRLAAEAFKGLLATSKAVHESSIDPTLMELLFLRVSQLNGCGYCMDMHGTALRKGGIEPRKLDTLPAWHESRFFDARERAALGWAEALTRLTDGAPSQAAFDALAPHFDEKGISDLSMGIAVINAWNRLGAGLLPPLP
>NC_015947.1|WP_014037798.1|2945213_2946110_+|RNA-polymerase-sigma-70-factor
MNPETAFQTHRPRLMALAYRLLGSRADAEDVVQDAWLRWSGVDPDAVRDPEAWLVTTTTRLGLDRLRAAKRERVHYVGPWLAEPLAVSLEPDPAPGPAQLHALADDVSVAFLTLLEQLGPEERAAFLLKEAFDHDYREIADLLGHSEANCRQLVHRARQRLQAGRPRFNADASQHRQLLARFMDASQRGDSEAIQALLHANAVLVSDGGGVVTAAVRPLLGAERIGRLFWAIARRGAVHPAQLGYVNGEPAILRFQGDRLHSVTTIEVVDGRIANVYSVLNPEKLPGVVTRDDGAASL
>NC_015947.1|WP_008268808.1|2943540_2945058_-|fumarate-hydratase
MTSIKQEDLIQSIADALQYISYYHPVDYIKNLAAAYEREESPAAKEAMAQILINSRMCAEGHRPICQDTGIVTVFLEIGMDVRWDDATMGVEDMANEGVRRAYMHPDNKLRASVLADPAGKRINTKDNTPGVVNVKVVPGNTVDVIVAAKGGGSEAKTKFAMLNPSDSIVDWVLKTVPTMGAGWCPPGMLGIGIGGTAEKAMLLAKEALMEPIDITELQARGASNRIEELRLELYEKVNALGIGAQGLGGLTTVLDIKINDYPTHAANLPVAMIPNCAATRHAHFTLDGSGPVMLDPPSLEDWPKLTYDASKGTRVDLDTITPEDVASWKPGQTLLLNGKLLTGRDAAHKRMVDMLNKGEQLPVDLKGRFIYYVGPVDPVRDEVVGPAGPTTATRMDKFTRQVLEQTGLLGMVGKAERGPAAIEAIRDNKSAYLMAVGGSAYLVSKAIKAAKVVGFADLGMEAIYEFTVQDMPVTVAVDSTGESVHKTGPREWQARIGKIPVVVE
>NC_015947.1|WP_014037797.1|2943077_2943416_-|hypothetical-protein
MALHRFIVAGVLLALAGCSTPASYEGADFPASAQCRMQCQASYRSCMAQNDSLGSRQSNCEQRMVPAPDKRCKDVANPELRRACELKAHDCTLRAPMMSCGERRDTCMSSCG
>NC_015947.1|WP_014037796.1|2942383_2943019_-|glutathione-S-transferase-family-protein
MSTTLYGSTSTAALVVHWLLIELGIEHELVLLDFDAREHKSAEYLALNPAGVVPTLLIDSLVLTEAAAIALYLADRHPEAHLLPALGTAQRADAYRWMFWCANTLQPAYRAWFYPNEVAGEANVEASREMAQQRLEAAWQHVATHLLAHGPYLLGATPCVVDYMLVMLMRWSRNMPRPSDTWPVLKAHASTMKARPAFAEVYRREGITDWR
>NC_015947.1|WP_014037795.1|2941970_2942312_+|arsenate-reductase-(glutaredoxin)
MDVTIWHNPACSNSRGALKLIRDAGFDPMVIEYLGNPPDATTLREVLAESGLDAQALVRSKEAQFTELGLEDADEATLLAAMAAHPRLINRPVVRTPKGTRLCRPPETVLEIL
>NC_015947.1|WP_014037804.1|2952563_2953679_-|cyclopropane-fatty-acyl-phospholipid-synthase
MDTGLQERVAGLLHEAGVRIGGTQPQDIQVHDPRFFARVMGHGSLGLGESYMEGWWDANVLDEFLVHLMQAHLDERVHGWREVADALKARLFNLQAGQGSYEVGRRHYDLGNDLYQAMLGQRLVYSCGYWRNADDLDAAQEAKLDLVCRKLGLRPGQRVLDIGCGWGEALKFAAERYGVSGVGVTISQEQAEFARELCAGLPIEIRLQDYRELDEPFDAIFSIGMFEHVGDKNYGSFFEVAKRCLSPRGLLLLHSIGTNISRHRTDPWIARYIFPNSMLPSAVQITKAFEGRFVLEDWHNFGTDYDLTLQAWRRNVEAAWPRLDAHYDEHFRRMWRFYLAGSMATFRCRHAQLWQLVLSPEGVPGGYVAPR
>NC_015947.1|WP_014037805.1|2953698_2954580_-|DUF3298-and-DUF4163-domain-containing-protein
MYKHEQGIPMKIGNNRPLHGSVLAGVVGVLLLAGCQRESEPAPATDAAPAAEATAAGETPATEAPLDLRDVIENNEREVVGISYPAGIDRYPGLARALQSYATSARSDLQQALDGLGNDKPTMPYELSLSFEKLLETPQLVVISADGSRYTGGAHGEPLVARFVWLPQHQQMLSAEKLVADAKGWKAISDFVADQLRERVATRLSGEDMDPAQLQESLRNASRMIADGTGPQADNFSQFQPLTDDKGQITALRFVFPPYQVGPYSDGTQTADVPAAVLLPHVAKDYVELFARG
>NC_015947.1|WP_005417588.1|2954617_2954920_-|N-acetyltransferase
MASVTPPGLAYEVEHDLANHRFTARVRGQLAVLDYQIKRKRMVITHTEVPEPIAGRGIAGELTRVALRFAREQKYKVVPACSYAEAFLQRHEEYHDLLVG
>NC_015947.1|WP_014037807.1|2955334_2955961_-|rhomboid-family-intramembrane-serine-protease
MTPVNLLLIAITAILSWMAFNNRKLADRLILWPPAIDRHRQYDRLVTYGFIHADWSHLIFNMITLFFFGGFIESVMVQLTGSYLTYPAFYIGALLVSILPSYLKNQKNPNYLSLGASGAVSAVLFAFILIKPWSIILVFFIPAPAIIYAAFYVGYSIWMDKRGGDRINHSAHLAGAAFGVIFMLAMQPSIFNHFLRELSNPTFRLGGG
>NC_015947.1|WP_014037808.1|2955968_2957534_-|MFS-transporter
MSHDAVAPIAGQGKMPRQIPYIIGNEACERFSFYGMRNILVQFLITSLLLQEITAEGRAGEAKDIMHSFMIGVYFFPLLGGWLADRFFGKYHTILWFSLVYCAGHLCLALFENSREGFFLGLGLIALGAGGIKPLVASFMGDQFDQSNKHLAKIVFDAFYWIINFGSLFASLLIPLVLKNWGPQWAFGIPGILMFIATFVFWLGRKRYVLVPLPPKDPHSFANVVRTALTARVAGQGRPGLVIAVLGLVLAVASFGLVGSLGIVICLCLALVAILAGIGGGTWLQLDRARGQHPAEAVEGVRSVLRVLVIFALTTPFFSLFDQKASTWVLQGQQMQMPSWFTASQMQALNPLLVMILIPFNNLVLYPALRRFGFEPTALRRMTAGIAFSGLAWIVVGGIQVVMDGGNAMSIFWQMLPYALLTFGEVLVSATGLEFAYSQAPQAMKGVVMSFWNLTTTIGNLWVLLSNAAVRNDTVTHQIAGTGLSEAAFLMFFFAGFAFVAALAFGWYAKRYRMVDNYRSA
>NC_015947.1|WP_014037809.1|2957696_2958545_+|endonuclease/exonuclease/phosphatase-family-protein
MRPLAHARLLLSCLLLLLALQAQARPQAPTAAASESEPRQLTVAALELPSRDDAQWKQRREQVAQLLTELQPDVISVQQVLQQQGRNPACWLASRLRYSCDFVTADPPSQPLRHGNAMLTRLPVSEDGVTLLHPPGTFSAAGMMRLKLGEALVNIYVARLRPDPDEATARQHQTSDLMTWIGATAEGMPSLIAGDFSANTVELVRSTPGFQPARRNPGGRAEAPAASGGGSSGHGLDVLFQVKHFGGIRQQPILLPADGDLPGLRLGVMATLRLQGIPAAAE
>NC_015947.1|WP_005410310.1|2958677_2959289_-|superoxide-dismutase
MAYTLPKLSYAYDALEPHIDAATMEIHHTKHHQTYINNVNAALEGTEYADLPVEELVKKLKSLPENLQGPVRNNGGGHANHSLFWTVMAPNAGGNPVGDVAKAIDKDLGGFDKFKDAFTKAALTRFGSGWAWLSVTPDKKVVVESTGNQDSPLMEGNTPILGLDVWEHAYYLKYQNRRPEYIGAFFNVIDWNEVERRYQEAIA
>NC_015947.1|WP_014037810.1|2959508_2959961_+|ribonuclease
MRNPRLLITAIALLLLGLVANHFLQRPPAPQFAPDLQGTPAARAPATASPGKDSGLPAFLPAEARATIALIQRGGPFPHRQDGSTFGNREQQLPQRARGYYREYTVDTPGARTRGTRRIVTGGDPPEAWYYTDDHYASFRSFTVPAQGAQ
>NC_015947.1|WP_014037811.1|2959960_2960374_+|barnase-inhibitor
MSHDDFGLGLHDINNAGVYAIDSDDIDALAAAMRDAGLKVIRIDLEGVADKRTLLARLAAQLDFPAGFGGNWDALSDNLRDLQWLPANGYALFLADVDTLRAGAQKDFDTLLDVMDETSRDWVGRDVPFWVFLSQSA
>NC_015947.1|WP_014037812.1|2960518_2962279_-|hypothetical-protein
MPLTRAEQLIDLLLARQQPRAVLEKTTRLPYGWALWLRSLGPLPRPFHARDVIAVFLPRPLPGPPGQSPRLSPWQALRRLFWQDWDAAPRDQRWMRWTSALVSALLHLLFFLLLLWVAVIRTTAPDEEGAEGERVQVEFVGRATQEGGGDQPGAEAAAAAAAGRVATGQEAGAATAPAPRPVAAEAAASSPASAPTTSVPPPPAEAEPAPVAAPPPSPVQATEVAQASTDFVVPPVSVPRTEVSVVPRDSTPVVRERSVQPVQAPPTPSQVRTPELAVRTPQVRDIQVREREVSTVDAPVAPQPLRSAEMQVRVPQQDVQVREREVQAVADPQVRMAAVAGREPAVRAPTGRDVQVREREVASAPVAAPASSRGSATAAPATAAQGSATQASSSTRPSASSNTPANAGARPAPDPGNWATPAKGDDWGSSSRNRDDASSGARQASTAGKGSGLFNADGSVRVPGQEGDGHAERGAPGGANDGWSKERIAQSGTWLKRPPYDYTPTSFDKYWVPQESLLAEWVRKGVKAMEIPLPGTNTRISCVISILQAGGGCGLTNPNMQDQPAVARPPPDIPFKKELQEDNGSR

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Crispr_ID: NC_015947_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015947_9

3079481-3079583

Unclear

Consensus_repeat	Method
TAAAGGGGGCGCGCCGACAGGCGC	CRISPRCasFinder

1 spacers

Cas9_archaeal

The CRISPR arrays of NC_015947_9

>merge|NC_015947|9|3079481-3079583|CRISPRCasFinder
TAAAGGGGGCGCGCCGACAGGCGCGGGGAATAGGAAGAATGCGCGGGCAACCCAGCGCGCCAACGGCGGGCTGGGTTGCTAAAGGGGGCGCGCCGACGGCGCA

>NC_015947|9|9|3079481-3079583|CRISPRCasFinder
TAAAGGGGGCGCGCCGACAGGCGC	GGGGAATAGGAAGAATGCGCGGGCAACCCAGCGCGCCAACGGCGGGCTGGGTTGC
TAAAGGGGGCGCGCCGACGGCGCA

Protein	Signature genes	Signature genes Name	Protein_function
NC_015947.1\|WP_014037912.1\|3085233_3085785_+\|GTP-binding-protein	unknown	unknown	gnl\|CDD\|225138
NC_015947.1\|WP_005417823.1\|3082544_3082748_-\|hypothetical-protein	unknown	unknown	unknown
NC_015947.1\|WP_042358867.1\|3073661_3074504_+\|methylated-DNA--[protein]-cysteine-S-methyltransferase	unknown	unknown	gnl\|CDD\|185333
NC_015947.1\|WP_014037905.1\|3076982_3077459_+\|LEA-type-2-family-protein	unknown	unknown	gnl\|CDD\|377000
NC_015947.1\|WP_014037896.1\|3068825_3069881_+\|sugar-phosphate-isomerase/epimerase	unknown	unknown	gnl\|CDD\|224007
NC_015947.1\|WP_014037910.1\|3083607_3084279_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NC_015947.1\|WP_014037903.1\|3074541_3075567_-\|NADP-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|176190
NC_015947.1\|WP_042359264.1\|3084619_3085237_+\|hypothetical-protein	unknown	unknown	unknown
NC_015947.1\|WP_014037914.1\|3086212_3086575_+\|hypothetical-protein	unknown	unknown	unknown
NC_015947.1\|WP_014037915.1\|3086684_3087131_+\|hypothetical-protein	unknown	unknown	unknown
NC_015947.1\|WP_014037904.1\|3076266_3076818_+\|lipocalin-family-protein	unknown	unknown	gnl\|CDD\|381213
NC_015947.1\|WP_014037913.1\|3085777_3086149_+\|roadblock/LC7-domain-containing-protein	unknown	unknown	gnl\|CDD\|214939
NC_015947.1\|WP_042358865.1\|3072275_3072761_+\|hypothetical-protein	unknown	unknown	unknown
NC_015947.1\|WP_014037901.1\|3072767_3073529_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|180993
NC_015947.1\|WP_014037906.1\|3077523_3079314_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|185635
NC_015947.1\|WP_014037907.1\|3079726_3080392_+\|HNH-endonuclease	Cas9_archaeal	cas9_archaeal	gnl\|CDD\|224321
NC_015947.1\|WP_014037897.1\|3069902_3070796_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NC_015947.1\|WP_014037898.1\|3070785_3071712_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|369561
NC_015947.1\|WP_005417825.1\|3082922_3083480_-\|DUF3011-domain-containing-protein	unknown	unknown	gnl\|CDD\|371422
NC_015947.1\|WP_042359262.1\|3080497_3082405_+\|1-deoxy-D-xylulose-5-phosphate-synthase	unknown	unknown	gnl\|CDD\|235470

Protein	Function_ID	Function_description	E-value
NC_015947.1\|WP_014037898.1\|3070785_3071712_+\|alpha/beta-hydrolase	gnl\|CDD\|369561	pfam07859, Abhydrolase_3, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	2.97277e-81
NC_015947.1\|WP_014037906.1\|3077523_3079314_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|185635	PTZ00456, PTZ00456, acyl-CoA dehydrogenase; Provisional.	0
NC_015947.1\|WP_014037905.1\|3076982_3077459_+\|LEA-type-2-family-protein	gnl\|CDD\|377000	pfam03168, LEA_2, Late embryogenesis abundant protein. Different types of LEA proteins are expressed at different stages of late embryogenesis in higher plant seed embryos and under conditions of dehydration stress. The function of these proteins is unknown. This family represents a group of LEA proteins that appear to be distinct from those in pfam02987. The family DUF1511, pfam07427, has now been merged into this family.	1.32175e-05
NC_015947.1\|WP_014037896.1\|3068825_3069881_+\|sugar-phosphate-isomerase/epimerase	gnl\|CDD\|224007	COG1082, IolE, Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism].	3.33394e-33
NC_015947.1\|WP_014037910.1\|3083607_3084279_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.00558e-45
NC_015947.1\|WP_014037903.1\|3074541_3075567_-\|NADP-dependent-oxidoreductase	gnl\|CDD\|176190	cd05288, PGDH, Prostaglandin dehydrogenases. Prostaglandins and related eicosanoids are metabolized by the oxidation of the 15(S)-hydroxyl group of the NAD+-dependent (type I 15-PGDH) 15-prostaglandin dehydrogenase (15-PGDH) followed by reduction by NADPH/NADH-dependent (type II 15-PGDH) delta-13 15-prostaglandin reductase (13-PGR) to 15-keto-13,14,-dihydroprostaglandins. 13-PGR is a bifunctional enzyme, since it also has leukotriene B(4) 12-hydroxydehydrogenase activity. These 15-PGDH and related enzymes are members of the medium chain dehydrogenase/reductase family. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES.	2.00138e-166
NC_015947.1\|WP_014037912.1\|3085233_3085785_+\|GTP-binding-protein	gnl\|CDD\|225138	COG2229, COG2229, Predicted GTPase [General function prediction only].	7.49394e-33
NC_015947.1\|WP_014037904.1\|3076266_3076818_+\|lipocalin-family-protein	gnl\|CDD\|381213	cd19438, lipocalin_Blc-like, bacterial lipocalin Blc, Arabidopsis thaliana temperature-induced lipocalin-1, and similar proteins. Escherichia coli bacterial lipocalin (Blc, also known as YjeL) is an outer membrane lipoprotein involved in the storage or transport of lipids necessary for membrane maintenance under stressful conditions. Blc has a binding preference for lysophospholipids. This group includes eukaryotic lipocalins such as Arabidopsis thaliana temperature-induced lipocalin-1 (TIL) which is involved in thermotolerance, oxidative, salt, drought and high light stress tolerance, and is needed for seed longevity by ensuring polyunsaturated lipids integrity. This group belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.	1.28993e-59
NC_015947.1\|WP_014037913.1\|3085777_3086149_+\|roadblock/LC7-domain-containing-protein	gnl\|CDD\|214939	smart00960, Robl_LC7, Roadblock/LC7 domain. This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.	2.85413e-13
NC_015947.1\|WP_014037901.1\|3072767_3073529_-\|SDR-family-oxidoreductase	gnl\|CDD\|180993	PRK07478, PRK07478, short chain dehydrogenase; Provisional.	1.49976e-135
NC_015947.1\|WP_014037907.1\|3079726_3080392_+\|HNH-endonuclease	gnl\|CDD\|224321	COG1403, McrA, Restriction endonuclease [Defense mechanisms].	1.54702e-19
NC_015947.1\|WP_014037897.1\|3069902_3070796_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.22123e-19
NC_015947.1\|WP_042358867.1\|3073661_3074504_+\|methylated-DNA--[protein]-cysteine-S-methyltransferase	gnl\|CDD\|185333	PRK15435, PRK15435, bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada.	2.49913e-94
NC_015947.1\|WP_005417825.1\|3082922_3083480_-\|DUF3011-domain-containing-protein	gnl\|CDD\|371422	pfam11218, DUF3011, Protein of unknown function (DUF3011). This bacterial family of proteins has no known function. Most members belong to Proteobacteria.	6.42894e-32
NC_015947.1\|WP_042359262.1\|3080497_3082405_+\|1-deoxy-D-xylulose-5-phosphate-synthase	gnl\|CDD\|235470	PRK05444, PRK05444, 1-deoxy-D-xylulose-5-phosphate synthase; Provisional.	0

>NC_015947.1|WP_014037906.1|3077523_3079314_+|acyl-CoA-dehydrogenase
MSSYTAPLSDLRFALHDVLKVEPLFARLGFTDATADVVDAVLEEAGRFSATVLAPLNSVGDEIGCVLDQATGEVTTPPGFKQAYDQFVDGGWTGLTASPELGGQGLPHTLGVPLNEMINAANLAWGNFPLLSHGAIEALKQHGEAWQHEAFLKPLIEGRWTGTMCLTEPHCGTDLGLLKTKAEPNADGSYSITGTKIFITAGEHDLTGNIVHLVLAKLPDAPPGAKGISLFVTPKFKVDREGNVGERNALRCGSIEHKMGIKGSVTCVMNFDGAQGYLVGQPHKGLQAMFTMMNTARLGVGLQGIGLSERAYQNALKYSRERLQSRALSGARFPDKPADPILVHPDVRRMLLTVKSLVEGSRLLALHAATLIDVAHHAEDAAERERADTLVSFLTPISKACQTEWGIENTYNALQCFGGHGYIREHGMEQLARDARITTLYEGTTGIQALDLIGRKTASSQGAGLKLMLAEIEAFAKEHEGNEALAEFIGPLRAKAAEWGKLTLDVLQRAAANPDELGAASYDYLFYSGYVVLAYWWARSVAAADASAHGAAFAQGKRETARFYFARVLPRTLSHAAAIQAGAAPLMAMDDERFGA
>NC_015947.1|WP_014037905.1|3076982_3077459_+|LEA-type-2-family-protein
MLHRFRTALIVLCTLALVACNNGIVKRVSEPAASLQQLTVRADGNWTVALRLQNFSSMPMTFDDVSLALTVGDNDAGTLQVKPGISIGGTSADVINVDLVPSSAARLVVADALASNRTLAYGLKGTVAATPQEKKQRSFDISSRSTLNQAPGLPGVLR
>NC_015947.1|WP_014037904.1|3076266_3076818_+|lipocalin-family-protein
MPLRPALLACLLLAAPPVIAAEPVRAVDTLDIDRYAGQWHEIAHLPVSFQKQCVGEITANYGLRRDGRISVTNACRNGEGERVVAEGMARPVAGHPGQLQVRFVPDWLSWAPLVWADYWVLALDPDYQWALVGEPDRKYLWILSRLPEMDRARFEQLKAKAEAMGYDLGPLRLMAPLRDTPAD
>NC_015947.1|WP_014037903.1|3074541_3075567_-|NADP-dependent-oxidoreductase
MSDPSTTSRIVLASRPQGAPSAANFRLEQVALPALADGEVLLRNRYLSLDPYMRGRMDEGPSYAAPVAVGAVMEGQTVAEVLRSNADGVTVGELVLAPGGWQSHAVLPAKALGRRLDPAGLPLSTALGVYGMPGFTAYSSLHEIARLKPGETLVVAAATGPVGATVAQLAKLQGAHVVAIAGGEAKRAYLQTLGVDVALDHRAADFAAQLRAAVPAGIDVYFENVGGHVLDAVLPLLNDFARIPVCGTIATYNERGVEQPGPDRLPALFSQILRQRLTVRGFIVHDFNHLWPDFEREMPQWLREGRIQYREDVVEGLEKAPEAFFGLLKGHNFGKLVVKLD
>NC_015947.1|WP_042358867.1|3073661_3074504_+|methylated-DNA--[protein]-cysteine-S-methyltransferase
MDSTATTALDARVERVCRHLQASLDEPSLQELADIAGCSPTRLHRLFKQATGLTPKQYAAALRADRLRTGLEHQERITDAFHDAGFGSSGRFYENAPKLLGMTPKQWRAGGRGEVIHFAIAESSLGSVLVASSGTGVVAILLGDDPETLLQSLQQRFRQAELVGADQGYEQLVAQVVGLVEDPTRGASLPLDIRGTAFQQRVWQALQQIPRGQTASYADIAARIGAPRSSRAVARACASNPLAVAVPCHRVVRRDGDLSGYAWGVARKRELLRREKASTA
>NC_015947.1|WP_014037901.1|3072767_3073529_-|SDR-family-oxidoreductase
MRLNNKIALITGASAGIGRASALRFAAEGAKLVLNARRPEPLQALAEQIRAAGGEAVVHAADVADPGTAQALVDLAQQSFGGLDIALNNAGMLGPGVPAAEFPADAWREVMTTNLDAAFHASRAQLPALLARGGGSLVFVGTFVGHTVGFPGMAAYASSKAGLIGLSQVIAAEYGARGVRSNVLLPGGTDTEMGRQAAPTGDARDFVRSLHALKRLAEPEEIANAALFLASDESSFVTGSAMRVEGGVSITRT
>NC_015947.1|WP_042358865.1|3072275_3072761_+|hypothetical-protein
MPSTSKRVASFVPMNFNPTDGSIQLGNLPALICPTLSQDEARIAFATLMHGERDVGTGYHWLSLHRLSLGGAPAGISLCFHGQRLDMVTMSVDLPGATLEDGWPTQAAIDAEVAFMRRTLATVLGRKLAGGHARFGWGEAWARFDPKGFMASSGIRYAPRT
>NC_015947.1|WP_014037898.1|3070785_3071712_+|alpha/beta-hydrolase
MQLEPALQQFVDAVAVHPLPEDLRELRAISESALPQLQGAPQPVAHVIEHTVIARDGHALDVRLYTPVGLPDERAPALLFAHGGGWFQCSLAVYDGPCRALANASGCVVVAVGYRLAPEHPFPVPLHDVADAWQWLQANADRLGLDPQRLAIGGDSAGGNLAAACCLLLRERGLPQPCHQLLLYPALDAGMGSDSYRDYATGYYLSAELMQRCWQAYLGGRDQPPSLASPAHATDLQGLAPATILSCEHDPLRDEAEQYAHRLQAAGVDCTLERLSGMIHACIHLQGVAASTGMAVQRAGALLRQALA
>NC_015947.1|WP_014037897.1|3069902_3070796_+|alpha/beta-hydrolase
MTTSLSAGAAGDASLRHHYLRIDGQRVHCVSAGHGEPVLLIPGWPQTWYAWRHVLHALAEAGFEAIAVDPPGIGESDRPAHGYDTGSAAAVLHQTMLALAHDRYQVVGHDIGMWIAYALASDQPQAVRQLAVTEAVIPGLAPEPGIFAAPADNIFLWHFMFNQVADLPEALITGRERAYLEFMFDRWSYRRDAVAADTYIAAYSRPGALRAGFAWYRAIPETIRQNKQRAQRRLPMPVLAIGAEHATGDAPMLTLQPHADDVRGSIVPGCGHFIMEEAPQAFLAQLLPFLQEARHAA
>NC_015947.1|WP_014037896.1|3068825_3069881_+|sugar-phosphate-isomerase/epimerase
MQTLKGPSLHLAQFAGDQAPFNSLAGIAAWAAGHGFKALQIPAWDARLFDLATAADSQDYCDDIRGTLAEHGLQVSELTTHILGQLVAVHPAYDELCDGFAPEALRGNPKARSEWAQQQLHLAARASRRLGLHDMGTFSGSFAWPYLFPFPQRPPGLIDAAFDELARRWRPILDTCEDNGINLCYEIHPSEDLHDGTSFERFFERVGQHERCRILFDPSHFVLQQLDYLQYLDIYHPLIRMFHVKDAEFRPSGRQGIYGGYADWTERAGRFRSLGDGQVDFKSIFSKLAQYDYPGWATLEWECCLKDQEAGAREGAAFIRDHIIPVTDKIFDDFAGAPISTAQMQQMLGIA
>NC_015947.1|WP_014037907.1|3079726_3080392_+|HNH-endonuclease
METDTTRLGLIEAGAPFSAPGAEASPNATTLHRPGSVRLLSLDAHGRVLDWITWQDAACLYAREAVAWTLGDPCLHIHGGTNRFSGLQSGMDLHPIIAARGHARSRAIDPTPNLTNQALFARDAHLCMYCGQQFNRPTLTRDHVMPLSKGGLDCWENVVTACFHCNSRKSDRTPQQAGMPLLAVPYRPSWIEHLILSNRNILADQMAFLKAQLPKRSKLST
>NC_015947.1|WP_042359262.1|3080497_3082405_+|1-deoxy-D-xylulose-5-phosphate-synthase
MIDSARYPRLARIQTPDDLRTFDESELRAVADELRAYLIESVGKSGGHFAAGLGVIELTVALHYLYQTPHDQLVWDVGHQTYPHKILTGRRDEIHTVKQKDGVAPFPKREESEYDTFGVGHSSTSISAALGMAIARQSEGDDRKVVAVIGDGAMTAGMAFEALMHAGGMEPEPNLLVILNDNNMSISEAVGGLTKMLGRATGSRTLNALREGGKKILGDKKNNPARFVKRWEEHWKGMFVPSTMFEEMGFHYTGPIDGHDMPALLSTLKTLRASKGPKLLHVMTTKGKGYEPAEGDQIGYHAVGPFDPDKGLVAKAGAKKPTYTDVFSDWLCDAAAAEPRLFGITPAMREGSGLVRFSKEYPQRYFDVAIAEQHAVTLAAGMATQGGKPVVAIYSTFLQRAYDQLVHDVAIQDLDVLFAIDRAGVVGPDGATHAGNLDLSFLRCVPNLVVMAPSNEAECRQMLSTGLQHPGPAAVRYPRGTGTGVAAGADLSTLPIGKGELRLQGSRIALLAFGSTVAAAEQVGRELGLSVVNMRFIKPLDRELVLAMAAQHEGLVTIEDNVVAGGAGSGVGELLNAEGVLRPILHLGLPDSYQHHASREDLLAEAGIDAAGIRAAVLKRWPQLAAGTPPLSAAG
>NC_015947.1|WP_005417823.1|3082544_3082748_-|hypothetical-protein
MLIRLQCEQRQWRVLHPDRPEPIEFRDGARAYDFAETLARLHFVDTGQRAAVRVEASGAFVEAVSYG
>NC_015947.1|WP_005417825.1|3082922_3083480_-|DUF3011-domain-containing-protein
MGKALTWRTLACTLLPMLAAAGGAQAQSYGYGYDDDRYGGRDGSGIVRCESVKNRSNECRLDGRARLIRQLSGSPCVEGETWGQSRNGVWVTQGCRAEFVGEYRRGGGWGGNGGGWGNGNGWGGGDVVTCHSNGHRQEYCDARIRRGVRLIRQDSRSACIEGQSWGWDRRGIWVSDGCRAQFQVN
>NC_015947.1|WP_014037910.1|3083607_3084279_-|response-regulator-transcription-factor
MLTRIAIADDHPLVLLGTRTVIEAGGHHRVVAEARCAESLLAILAEEPVDLVVTDFSMPDVGRSDGQAMLQALNRNYPKVPVILVTMVTNATTLNMAMRTGVRGLVWKCSCVDGTRKAVDTVLSGGIYLDPQLAHCLQEGGRERSLSVLSPKELEVLRLYVSGPSITEIAGQLRRTVSTISRQRISAMRKLGISNDAELFAYAFEERLGNAGGMASGAANGSP
>NC_015947.1|WP_042359264.1|3084619_3085237_+|hypothetical-protein
MPFVQQLRLHLASDGALPRRSAHAAIIHDGATVCWLDARNDRMMTTAPAPITLTLLQRLLGDADPRLSLVPVTQEVFVQRATVCSNVPLRLTLWNVALVTDGRGVPIPPLQDCTKLRLRRWPDFRILAHRPDHFRLCALMIKQGASVRACCDILDLPRQSVQSFFNAAFLTAYAFPVVGEDAPVRPSPADGLVNLWRQLRIRWSA
>NC_015947.1|WP_014037912.1|3085233_3085785_+|GTP-binding-protein
MTVREHKIVVMGPLGAGKSTLVQTLTQGTAVVTEAPNTDPTVGKQYTTVAMDYGDIDLPGGDRLRLYGSPGQERFSYIWPILLAGAEGAIVLIDGSASVGATLAGRHLRAIAESAPGLPVVIGFTRCGSTDDPVQPHWQDWLQDHAPHLPALPLDPRDMAQAVTAMDLLMSQIECNAMAATHE
>NC_015947.1|WP_014037913.1|3085777_3086149_+|roadblock/LC7-domain-containing-protein
MNDIDRTSALDALVHDVTGIQALVVASTDGFALAQAGPKSHVADRLAAMTSSMLGLASALGRELHFGELDTLILDAANGKVLMLAIPGKQPRLLMTACDHSCVIGNVLWHAKQCVRALANTPT
>NC_015947.1|WP_014037914.1|3086212_3086575_+|hypothetical-protein
MNIAINKCLDTLMQINGAQAVALVDFESGMLLGDAGSGVDMELAAAGNTEVLRAKMKTAEALNLNDNIEDVLITLGRAYHVLRPVSAKKGLFFYVVLDRQKANLALARRIVLDVESSLAL
>NC_015947.1|WP_014037915.1|3086684_3087131_+|hypothetical-protein
MRPRSSTQATHHSRHYRRWASVSIVAGLTAIYALLLCAPRLDDDASRTRLRDAANVLGGAIAAVENSYAEGDLTVTDPHLGLPASAAHCARLRASLPDTGRAVLTCDLHQEGSVRWRRTPAGEWRCTASTADVHAVPTPCPTELQRTF

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Crispr_ID: NC_015947_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015947_10

3525572-3525682

Orphan

Consensus_repeat	Method
TTGGGTGGGTGCGGACCGTTGGTCCGCAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015947_10

>merge|NC_015947|10|3525572-3525682|CRISPRCasFinder
TTGGGTGGGTGCGGACCGTTGGTCCGCACACGGTAGTGCCGGCCGCTGGCCGGCAACTTCATGATCCGGGTGCGGATCTGCTTTGGGTGGGTGCGGACCGTTGGTCGGCAC

>NC_015947|10|10|3525572-3525682|CRISPRCasFinder
TTGGGTGGGTGCGGACCGTTGGTCCGCAC	ACGGTAGTGCCGGCCGCTGGCCGGCAACTTCATGATCCGGGTGCGGATCTGCT
TTGGGTGGGTGCGGACCGTTGGTCGGCAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015947.1\|WP_014038256.1\|3530749_3531520_-\|peptidoglycan-editing-factor-PgeF	unknown	unknown	gnl\|CDD\|182677
NC_015947.1\|WP_014038257.1\|3531519_3532509_-\|23S-rRNA-pseudouridine(1911/1915/1917)-synthase-RluD	unknown	unknown	gnl\|CDD\|183020
NC_015947.1\|WP_014038246.1\|3516629_3517340_+\|glutathione-S-transferase	unknown	unknown	gnl\|CDD\|373097
NC_015947.1\|WP_014038247.1\|3517419_3519024_-\|membrane-protein	unknown	unknown	gnl\|CDD\|225161
NC_015947.1\|WP_014038243.1\|3511997_3512798_+\|MipA/OmpV-family-protein	unknown	unknown	gnl\|CDD\|226236
NC_015947.1\|WP_014038252.1\|3526597_3528379_+\|glycoside-hydrolase-family-15-protein	unknown	unknown	gnl\|CDD\|225922
NC_015947.1\|WP_014038242.1\|3510567_3511857_+\|two-component-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|236724
NC_015947.1\|WP_014038253.1\|3528375_3529740_+\|alpha,alpha-trehalose-phosphate-synthase-(UDP-forming)	unknown	unknown	gnl\|CDD\|274112
NC_015947.1\|WP_014038259.1\|3533716_3534919_+\|lipase	unknown	unknown	gnl\|CDD\|367570
NC_015947.1\|WP_014038254.1\|3529810_3530248_-\|thiol-disulfide-oxidoreductase-DCC-family-protein	unknown	unknown	gnl\|CDD\|225556
NC_015947.1\|WP_014038255.1\|3530222_3530729_-\|DUF4166-domain-containing-protein	unknown	unknown	gnl\|CDD\|379359
NC_015947.1\|WP_014038244.1\|3512870_3515456_-\|ATP-dependent-chaperone-ClpB	unknown	unknown	gnl\|CDD\|274529
NC_015947.1\|WP_014038250.1\|3523115_3525551_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|238657
NC_015947.1\|WP_010481551.1\|3522418_3522901_-\|DUF3574-domain-containing-protein	unknown	unknown	gnl\|CDD\|371896
NC_015947.1\|WP_042358918.1\|3532622_3533510_+\|outer-membrane-protein-assembly-factor-BamD	unknown	unknown	gnl\|CDD\|274513
NC_015947.1\|WP_014038249.1\|3521524_3522382_-\|hypothetical-protein	unknown	unknown	unknown
NC_015947.1\|WP_014038245.1\|3515637_3516459_-\|DUF3014-domain-containing-protein	unknown	unknown	gnl\|CDD\|378600
NC_015947.1\|WP_014038248.1\|3519673_3521392_-\|pyruvate-oxidase	unknown	unknown	gnl\|CDD\|181661
NC_015947.1\|WP_014038251.1\|3525799_3526558_+\|trehalose-phosphatase	unknown	unknown	gnl\|CDD\|319767
NC_015947.1\|WP_014038260.1\|3535130_3536765_-\|NAD+-synthase	unknown	unknown	gnl\|CDD\|237577

Protein	Function_ID	Function_description	E-value
NC_015947.1\|WP_014038256.1\|3530749_3531520_-\|peptidoglycan-editing-factor-PgeF	gnl\|CDD\|182677	PRK10723, PRK10723, polyphenol oxidase.	1.55559e-89
NC_015947.1\|WP_014038257.1\|3531519_3532509_-\|23S-rRNA-pseudouridine(1911/1915/1917)-synthase-RluD	gnl\|CDD\|183020	PRK11180, rluD, 23S rRNA pseudouridine(1911/1915/1917) synthase RluD.	1.70408e-146
NC_015947.1\|WP_014038246.1\|3516629_3517340_+\|glutathione-S-transferase	gnl\|CDD\|373097	pfam14497, GST_C_3, Glutathione S-transferase, C-terminal domain. This domain is closely related to pfam00043.	1.53823e-29
NC_015947.1\|WP_014038247.1\|3517419_3519024_-\|membrane-protein	gnl\|CDD\|225161	COG2252, COG2252, Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism].	2.31977e-07
NC_015947.1\|WP_014038243.1\|3511997_3512798_+\|MipA/OmpV-family-protein	gnl\|CDD\|226236	COG3713, OmpV, Outer membrane protein V [Cell envelope biogenesis, outer membrane].	1.56159e-37
NC_015947.1\|WP_014038252.1\|3526597_3528379_+\|glycoside-hydrolase-family-15-protein	gnl\|CDD\|225922	COG3387, SGA1, Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism].	2.42643e-83
NC_015947.1\|WP_014038242.1\|3510567_3511857_+\|two-component-sensor-histidine-kinase	gnl\|CDD\|236724	PRK10604, PRK10604, sensor protein RstB; Provisional.	3.64878e-70
NC_015947.1\|WP_014038253.1\|3528375_3529740_+\|alpha,alpha-trehalose-phosphate-synthase-(UDP-forming)	gnl\|CDD\|274112	TIGR02400, Alphaalpha-trehalose-phosphate_synthase, alpha,alpha-trehalose-phosphate synthase [UDP-forming]. This enzyme catalyzes the key, penultimate step in biosynthesis of trehalose, a compatible solute made as an osmoprotectant in some species in all three domains of life. The gene symbol OtsA stands for osmotically regulated trehalose synthesis A. Trehalose helps protect against both osmotic and thermal stresses, and is made from two glucose subunits. This model excludes glucosylglycerol-phosphate synthase, an enzyme of an analogous osmoprotectant system in many cyanobacterial strains. This model does not identify archaeal examples, as they are more divergent than glucosylglycerol-phosphate synthase. Sequences that score in the gray zone between the trusted and noise cutoffs include a number of yeast multidomain proteins in which the N-terminal domain may be functionally equivalent to this family. The gray zone also includes the OtsA of Cornyebacterium glutamicum (and related species), shown to be responsible for synthesis of only trace amounts of trehalose while the majority is synthesized by the TreYZ pathway; the significance of OtsA in this species is unclear (see Wolf, et al., ). [Cellular processes, Adaptations to atypical conditions].	0
NC_015947.1\|WP_014038259.1\|3533716_3534919_+\|lipase	gnl\|CDD\|367570	pfam03583, LIP, Secretory lipase. These lipases are expressed and secreted during the infection cycle of these pathogens. In particular, C. albicans has a large number of different lipases, possibly reflecting broad lipolytic activity, which may contribute to the persistence and virulence of C. albicans in human tissue.	3.34161e-05
NC_015947.1\|WP_014038254.1\|3529810_3530248_-\|thiol-disulfide-oxidoreductase-DCC-family-protein	gnl\|CDD\|225556	COG3011, COG3011, Predicted thiol-disulfide oxidoreductase [General function prediction only].	1.2235e-48
NC_015947.1\|WP_014038255.1\|3530222_3530729_-\|DUF4166-domain-containing-protein	gnl\|CDD\|379359	pfam13761, DUF4166, Domain of unknown function (DUF4166). This domain is often found at the C-terminus of proteins containing pfam03435.	1.0079e-21
NC_015947.1\|WP_014038244.1\|3512870_3515456_-\|ATP-dependent-chaperone-ClpB	gnl\|CDD\|274529	TIGR03346, chaperone_ClpB, ATP-dependent chaperone ClpB. Members of this protein family are the bacterial ATP-dependent chaperone ClpB. This protein belongs to the AAA family, ATPases associated with various cellular activities (pfam00004). This molecular chaperone does not act as a protease, but rather serves to disaggregate misfolded and aggregated proteins. [Protein fate, Protein folding and stabilization].	0
NC_015947.1\|WP_014038250.1\|3523115_3525551_+\|TonB-dependent-receptor	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	6.88734e-64
NC_015947.1\|WP_010481551.1\|3522418_3522901_-\|DUF3574-domain-containing-protein	gnl\|CDD\|371896	pfam12098, DUF3574, Protein of unknown function (DUF3574). This family of proteins is functionally uncharacterized. This protein is found in bacteria and viruses. Proteins in this family are typically between 144 to 163 amino acids in length. This protein has a conserved TPRF sequence motif.	3.15793e-45
NC_015947.1\|WP_042358918.1\|3532622_3533510_+\|outer-membrane-protein-assembly-factor-BamD	gnl\|CDD\|274513	TIGR03302, OM_YfiO, outer membrane assembly lipoprotein YfiO. Members of this protein family include YfiO, a near-essential protein of the outer membrane, part of a complex involved in protein insertion into the bacterial outer membrane. Many proteins in this family are annotated as ComL, based on the involvement of this protein in natural transformation with exogenous DNA in Neisseria gonorrhoeae. This protein family shows sequence similarity to, but is distinct from, the tol-pal system protein YbgF (TIGR02795). [Protein fate, Protein and peptide secretion and trafficking].	3.2459e-90
NC_015947.1\|WP_014038245.1\|3515637_3516459_-\|DUF3014-domain-containing-protein	gnl\|CDD\|378600	pfam11219, DUF3014, Protein of unknown function (DUF3014). This family of proteins with unknown function appears to be restricted to Proteobacteria.	3.36968e-55
NC_015947.1\|WP_014038248.1\|3519673_3521392_-\|pyruvate-oxidase	gnl\|CDD\|181661	PRK09124, PRK09124, ubiquinone-dependent pyruvate dehydrogenase.	0
NC_015947.1\|WP_014038251.1\|3525799_3526558_+\|trehalose-phosphatase	gnl\|CDD\|319767	cd01627, HAD_TPP, trehalose-phosphate phosphatase similar to Escherichia coli trehalose-6-phosphate phosphatase OtsB and Saccharomyces cerevisiae trehalose-phosphatase TPS2. Trehalose biosynthesis in bacteria is known through three pathways - OtsAB, TreYZ and TreS. The OtsAB pathway, also known as the trehalose 6-phosphate synthase (TSP)/ Trehalose-6-phosphate phosphatase (TPP) pathway, is the most common route known to be involved in the stress response of Escherichia coli. It involves converting glucose-6-phosphate and UDP-glucose to form trehalose-6-phosphate (T6P), catalyzed by TPS, the product of the otsA gene, this step is followed by the dephosphorylation of T6P to yield trehalose and inorganic phosphate, catalyzed by a specific TPP, the product of otsB gene. This OtsAB (or TSP/TPP) pathway, is also the most common route known to be involved in the stress response of yeast In Saccharomyces cerevisiae, the corresponding enzymes, TPS1p and TPS2p, form a multimeric synthase complex together with additional regulatory subunits encoded by Tsl1 and Tps3. Trehalose is a common disaccharide accumulated by organisms as a reservation of carbohydrate and in response to unfavorable growth conditions. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.77967e-64
NC_015947.1\|WP_014038260.1\|3535130_3536765_-\|NAD+-synthase	gnl\|CDD\|237577	PRK13981, PRK13981, NAD synthetase; Provisional.	0

>NC_015947.1|WP_014038250.1|3523115_3525551_+|TonB-dependent-receptor
MSARLPASPLGLAIAIALSSAAVPALAQDATSLDTVIVTGTRAADRTVLESTSPVDVLTAEDIRKAGVVNGELGSALQALLPSFNFPRQSNSGGADHVRAAQLRGLSPDQVLVLVNGKRRHHTALVNTDSKIGKGTTPVDFNSIPVSAIKRIEVLRDGAGALYGSDAVAGVINVILDNGGDGGEIEASYGANHTDLKPIGRTLTDGQTGNISAKVGTSLGEDGGFLRVGLEYKHRNGTNRAGFDQIPPWDQTPDNLALQGKRNYVLGDGKSKDINLWLNTEIPVGQTSTFYAFGTFNQRDTEGANYFRYPDGDANWKQVYPSGYRPISEGENRDAQAVAGVRGQWGEWSYDGSLDYGQNDFTYRLRDSLNASLGPTSPTRFKTADYEYAQTVGNLDLSRVFTQSDSISHTLGLGVEARHERYQTRPGDPASYAAGPYTDRPTGSQAGGGLTPQDAARLSRDVASAYASLSSQFGEKFSTDLAARYEHNDDFGGELTGKLGLRYEFTPAFALRGAISNNFRAPSLAQIGYESTSTGYNAGGQLVQGRLLSVNNPIARGLGAQNLKPEKSINTSLGFTSRIGEHFDLSLDFFQIDIDDRIALSESITGDALTDYVAANYGVSGLQSASFFVNAADTRTRGAELVSNWRQSLGDGQLLLTGTYAYTKTTLKNVLATPAQLRALNPDYVLFGIEETNTLTDATPRTRGSFSVAWSNDHWSLSTRVNRYGSATRVFNFGDGYIPRQTYQAEWQLDAEVEYRITPRWSVAIGGQNLTDNYPDRSNSDIHYFGNLPYDVLSPIGSNGAYYYGRVRYTF
>NC_015947.1|WP_010481551.1|3522418_3522901_-|DUF3574-domain-containing-protein
MKHLGLVFAVLLATSGCASLSSQAPSAYATATTAELKGDAARPSAGHGWVRSELYFGVGEEQGAGNRPQADTISEAQWRTFLDKEVTPRFPDGLTVFDAYGQWLFRGDAAPNRLRTKVLVVLHEDTPQRRADIEAIRLAWKQQTKHQSVLWSRQPVEVSF
>NC_015947.1|WP_014038249.1|3521524_3522382_-|hypothetical-protein
MNYRECMLGLMLAGVLAPTAQARRDDGETLRFQVAAHVQAHADPQQDGSIVVQLSPSGKRQTLAGAADADGNSRWSLEDVDFDGYPELVARASVGMVNEAVAVYRFDPASAGFRALQADTHGRDSCGDLMGLSVDRPSRTLTSSCRSGPMWYTDQYRFSGATLYLYRSETVLMLGDTVNAALHWEQTDEQGPLAVWRTYDPAGRVLESAIGDGLGAPPDGPLRGQQATVVPARLFLFDRPGASSTKRYLVHGDRVEMLDEQDGWMKLRYRNPKQGAVEGWINVND
>NC_015947.1|WP_014038248.1|3519673_3521392_-|pyruvate-oxidase
MSKRVAEIVVDALQQAGVRRCYGIVGDTLNHVTDAMHGSEIAWVHVRHEEVAAFAAGADSLVSGELTACAGSCGPGSLHFINGVFESNRNRAPMVLIASQVVTSELGMEFPQEVDFKAVYASCSVFCEQVHSAEQARRVVTLACQAAISRRGVAVVILPADISQAEVKHDVPFSVHYTQPVLRPSDAELQRIAELLGQGKRIGIYAGAGCQGAHAQLLELARRLQAPIAHTSRAKDFVEPDNPYNMGMTGIFGIESGFHTLMECDTLLLLGADFAWGQFYPDKATIIQVDRDGSHLGRRHPVNLGVVGDIAPTLDALLPMLPPREDSSFLDECIERRDKALKKREQEEQPGEGELIHPQHLTALLSKYATDDALFTADGGSPMVWVLRHIRVNGRRRTLTSLLHGTMANAMPQALGLQKAFPGRQVISLSGDGGLAMLLGDLLTAVQENLPIKVVVFNNGSLNFVELEQKVEGLLDNYTDLKNPDFGRLAEVIGFHGRTVTRSEDLEEAVQDFLSQRGPALLDVHTSRAELVMPPQIEAKQVAGTALYAAKAVLNGRFDDVKHLLVDNFLKK
>NC_015947.1|WP_014038247.1|3517419_3519024_-|membrane-protein
MSAPASAAPRRWFVAGDFNGFFGLVVDNLSILGFIAMALVGIFQFPADVVFGRMFPGTAFGVLVGNLLYTLMARRLAARTGRDDVTAMPLGLDAPTSIGMALLVLGPAFIAFKQQGMDPHAAGIATWQLGMAALVIMGVLKFVLSFFGEAVTRALPRAALLGSIAGIALVLMGLLPLLETLRSPLVGFTTLGLLLYVLIAKGKLPVCGPGVLLAFVFGTVLYYGLGLAGLGAPGFHVPAWVPPQVVLPLPTLGFLDGLPTAMTYLPLLLPFGLLMVVGGINVSESARAAGDDYRTRDILLVEAVATLVAGVCGGVAQTTPYIGQPAYKHMGARSGYTLLTGLFVGIGGMLGIISGLVQWLPLAVLAPIIVYVAIDITTQAFQATPRHHTGAMVFGFLPSVAYLLAIKAPGWIAPDQLPQLLTKLDGHGLPELAVIFTLGNGFIITSMLWISAVAAMVDGRLRRACGFLLVAAGLTLFGLIHSVDPRGGIYLPWDLDGLARIISWQFAGAYVALALLLGLLSLQKQAVKPLGENS
>NC_015947.1|WP_014038246.1|3516629_3517340_+|glutathione-S-transferase
MQYALYYWTGIQGRGEFVRLALEDAGADYIDMARVHGDAVMQPFLDGSSEGAQPFAPPFLKAGRQVIAQVAAILDFLGPSLDLVPQAASRRLQALQLQLTIADLVAEVHDTHHPIAASKYYEEQKTEARARAASLRSERLPKFLGYFEHVLVANGGRHALREHSYVDLSLFQLLSGLDYMFPRRMQALGPTLPRLRALQERVAKRPNIAAYLASARRLPFNTNGIFRHYPELDAER
>NC_015947.1|WP_014038245.1|3515637_3516459_-|DUF3014-domain-containing-protein
MQSGKAVWPWVLGVVVIGGAGGWLFRDQLKSLADGVSVPVQSPPASTGAPPQPKAAAEPALAPPPIRHPLDAEAAADPALPKLADSDAAAWGALSQLFQGEGPLTLLLRDHLIQRLVTQVDNLDKPSVPPTALAARPLPGNLQVEPGEGGERIAASNAARYAPYVQAFTALDPVATATAYKRFYPLIQQAYVDLGRPEGYFNDRLVTVIDHLLETPELAQAPLVQRDERGRYRFVDPTLQSRSIGQKALLRMDPAQARAVKQQLRAIRSAITR
>NC_015947.1|WP_014038244.1|3512870_3515456_-|ATP-dependent-chaperone-ClpB
MRMDKLTSRFQQALADAQSLAVGRDNSIIEPVHLFSALLDQQGGSTRPLLAQAGVNVPVLRERLTEALDALPKVSGQAGNVSMGNDLGRLLNQTDKLAQQNGDAFIASEWFVLAALDDGGTLGMALRAAGADKTRLQAAIDKLRGGENVQSENAEEQRQALEKYTIDLTARAESGKLDPVIGRDEEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINDEVPEGLRGKRVLSLDMGALIAGAKFRGEFEERLKGVLNDLAKSEGQIILFIDELHTMVGAGKADGAMDAGNMLKPALARGELHCVGATTLDEYRKYIEKDAALERRFQKVFVGEPSVEDTIAILRGLKEKYAVHHGVEITDPAIVAAATLSNRYITDRQLPDKAIDLMDEAASRLRMEIDSKPEELDRLERRVIQLKIQREMLKKEKDEASRQRLADLEKDIDALEREFSDLNEIWKSEKAALQGATKIKEQVEQAKLELESAQRRQDFAKMSEIQYGLLPQLEKQLAAAQEAEHKDFKLVQDRVTDEEIAEVVSRWTGIPVNKMLEGERDKLLRMEEVLHNRVVGQEEAIRVVSDAVRRSRAGLSDPNRPAGSFLFLGPTGVGKTELCKSLAEFLFDSADAMIRIDMSEFMEKHSVARLIGAPPGYVGYEEGGYLTEAVRRRPYSLILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNTVIVMTSNLGSHQIQDMSADDSPEAYTQMKAAVMGVVQAHFRPEFINRLDDIVVFHPLDKQQIKQIARIQMRGLEKRLAERGLKLMVSDAAFDLLGNVGFDPVYGARPLKRAIQAQLENPLAQKILSGAFVNGDTIEVGNDGGHLVFAKA
>NC_015947.1|WP_014038243.1|3511997_3512798_+|MipA/OmpV-family-protein
MSQLRRSPTLLCLALLPLFATPIAHAKDDHWTFELAAGGGVTPRYSGSEEYRATPSLSFDVTSPGGWFLGTSGIGWGTALGEHTRVRAYVGASGIRKDKDSLLGGSDFLRGMGDIDTRPLVGVSAGYTLGEAVLSGSWQFTRKDEDKAENGLATQQIHLNLTLPLFDLAGGVVSGSVSTDYGNRGYMQTWYGVSPEQAKRTGFAEHKPKAGLVSAGVGLKWSHRAGRNGNWYISAEGTRLLGDAANSPIVQKPNQFGLMSGYTHRF
>NC_015947.1|WP_014038242.1|3510567_3511857_+|two-component-sensor-histidine-kinase
MKRLFLWLWFVTGACFLVSVFFLNHILDGIYTPVQDRVFVEQVRGQVYALRSGLAGLDAGQQRERLQQLQPHYGITLTLLDNPPALDRQEQAAVQADGFIVRDQYQQVLLPIEGIGGRWLHLRLPGAVQMTMYMTIAAYLSILLLVGASLYAWVRLLWRDLEALRRHADRIGAGDLQARAQVSPRSQIRVIVDHSNRMAARVAELVQRQRDLTHAISHELRTPIARVAFGLDLMQDSDDRERRARLAQGLHGDLAELNRLVSELLAYERLEHPSEGEPMQRIEANDWLQACLADARRDAERAGLVLRVQPSALPRVDAEPRLLQLALSNLVGNALRHARSQVEVWLVGVGGRACLRVDDDGPGIAEADHEKVMRPFTRLDDSRSRDTGGFGLGLAIVGRIAARHGGELRISRASLGGARLEMHWPLAAS
>NC_015947.1|WP_014038251.1|3525799_3526558_+|trehalose-phosphatase
MAEPLPLRPPPPLLDDACALFLDVDGTLIEFAARPDAVQLLPDVREAIGRISDRLEGAVALVSGRPLAQLDQLFAPLKLPAAGLHGHELRGEDGRVLRDEHDEDTAEWLHALHQQAMRFAHGHPGVLVEDKGVGLALHWRGAPHAASDVRAFADRHVRGRASYRLQPGDHVVEFVPVGTDKGRAVRRMMQYLPFRGRLPVFLGDDLTDEFGFDAANGQHGWSVLVGEREPSKAVFALPDIRSVHAWLRENAY
>NC_015947.1|WP_014038252.1|3526597_3528379_+|glycoside-hydrolase-family-15-protein
MTQPDLDLGVVGNGSFGALVDKRARVVWSCLPTFDGDPTFCALLGPNQQTGGDFAIELEDFASSEQEYLTNTAILRTVLRDAHGGELEILDFAPRWRQNDRFYRPVSLIRQVRPLAGSPRITVHARPLADWGARVPESTWGSNHVRWILPEHVLRLTTDVPVRFIRDGLPFVLNHPIHLILGVDESLNRSISGYVQEAFQRTRDYWREWVRYLSIPLEWQDAVIRSAITLKLCQYEDSGAIIAAMTTSIPEAPGSVRNWDYRYCWLRDAAFVVRALNRLGATRTMEQFLGYIFNLATTDGTLQPLYGIGFEAKLDEDEVPSLSGYRGMGPVRRGNLAWVQRQHDVYGSVVLASTQLFFDRRLQDPGDAHTFARLEPLGEQAFALHDVPDAGLWEFRGRTEVHTYTSAMCWAACDRLCKIAVRLKRDDRAHYWRERADTIHARIMAESWSEELGHFTDTFGGHRLDASLLLLADIGFIDALDARFVATVEAIGRDLKHGNSLYRYVAPDDFGEPETSFTICTFWYIDALAAIGRMDEARGMFELLLKQRNHLGLLSEDLAFDSGEAWGNFPQTYSHVGLITAAMRLSRSWQEAS
>NC_015947.1|WP_014038253.1|3528375_3529740_+|alpha,alpha-trehalose-phosphate-synthase-(UDP-forming)
MSRLVVVSNRVAVPGENRAGGLAVGLLAALKERGGMWFGWSGKSVRDGSGTLHTQKDGDIEFVTLDLSKREVDGYYNGFANRTLWPLLHFRLDLVDYDRGTRETYHKVNALFADKLAPLLREDDIVWIHDYHLIPLGALLRERGIGCRIGFFLHIPMPSADLLQAMPDHLRLFSALYAYDLVGFQTQRDADRFQTYLRLFGGGRVLDNGELEAPGGRRFRAAAFPIGIDTELIARQAGTAATKAAVKNLRASLRDRQLAIGVDRLDYSKGLPERFLGFERYLERHPDQRGSLTYLQIAPVSRGDVTEYRQLRSQLEQIAGHINGGHAEPDWTPLRYVNQNFTHATLTGFYRAAAVGLVTPLRDGMNLVAKEYVASQDPEDPGVLVLSLLAGAADELKQALLVNPHDLDGVADAIATAATMSLRRRKERWHAMMEHLRTYDINHWRRSYLDALEG
>NC_015947.1|WP_014038254.1|3529810_3530248_-|thiol-disulfide-oxidoreductase-DCC-family-protein
MKAGSNRSDAAAEAGSAVIVFDGVCALCNRWVRFLLRFDRKGRYRFAAMQGQQGSAMLRAHGLDPQDPMSFLLLDAQGAWTDTDAILRVLTGLGGAWRLSGMLRMVPRRWRDAAYRTLARNRYRWFGRHDACHLPAPEQAARFLD
>NC_015947.1|WP_014038255.1|3530222_3530729_-|DUF4166-domain-containing-protein
MLGPAFATLAAPVQALHVAPLPCRYVGQARIVRGRHWLVPLLAALARLPKDGDALPTEVAFSARGQGEQWARRFGRWPMVSRLWAHEGYLREQLGAVRFEFALQARDGGIDWSVRRVWAFGLLPLPTRWFGGVRCREAWQGERYTFLVDVTLPWAGALIRYEGWLEPQ
>NC_015947.1|WP_014038256.1|3530749_3531520_-|peptidoglycan-editing-factor-PgeF
MAVALPLLQADWPAPAGVHALTTRRHGAGISPAPFAQFNLGNRHAADGDTPANVEHNRQLLQQGLALPSAPHWLRQVHSSTVLRFTAPPVAGVSEPVADAAVTSVPGVVLAILTADCLPVVFAAADGSEVGAAHAGWRGLADGMLEATVAAMQTPPAQLRAWLGPAAGPADYEIGEEVFHAFVGHDPAAEAAFVATRAGHWKVDLFALARQRLQAAGMDPAQVYGGTVSTMADPDLYSHRRDRRTGRMATLAWIAP
>NC_015947.1|WP_014038257.1|3531519_3532509_-|23S-rRNA-pseudouridine(1911/1915/1917)-synthase-RluD
MSEQPSESARQAIVPDTAAGRRFDAVVAELFPEYSRSRLTEWIKSGDVLLDGAQVRPRDPLRGGEVVTLHVVLETQTDAQPEDIPLDVLFEDEHVLVINKPVGLVVHPGAGNHSGTLVNALLFRDPSVAVLPRAGIVHRLDKDTSGVMVVAKTLEAQTALVEQLAARDVHRQYLAIVMGALVAGGTADAPIDRHPRDRLKMAVREDGKEAVTHYRLRERFRAHTALECRLETGRTHQIRVHMAHVRHPIIGDPLYGGALKLPKGASDELVAALRGFKRQALHAETLEFMHPITGEPVRNTAPVPEDMLHLMKVLREDSEAFAARERDRW
>NC_015947.1|WP_042358918.1|3532622_3533510_+|outer-membrane-protein-assembly-factor-BamD
MIRRSAMLSAPVRLTALLLVLVIAATGCHRGAKKGDRPDEGTPVEQLYEKSHKLMQGGNWSGAEASFRRLVAQYPYGPYTEQAMIETAYAQYKAGKHDDAVSSIDRFIRTYPTHRNIAYLYYLRGLANSNRSTVFLRRVWSLDASRRDLSTPHQAYSDFNIVVDRYPNSRYAADARQRMLELRDVFAQHELDNALYYMRRGAWVSAVGRANYLLETYPQSAFQYDAVAVLADSYTHLGNKTLADDARRVLQLNQPDHPWLEGKWPKYPWMIRKLNPFAGEKSASTGQRNARLEKK
>NC_015947.1|WP_014038259.1|3533716_3534919_+|lipase
MSPLPLRFRPLSSLLATALLALSSSPLTAAPVSPGDLLSAAPHRASWVPSKAAQAYKLHYRTPDHRGQLAEGTGLLYLPAGAAPAGGWSVVSWAHGTQGIADRCAPSVSGPYQPERDGRFLDQFLAQGYAVVAADYQGLGSPGDHAYLHVRTAARNAIDLVKASRQYLGNATLSPRWVSVGHSQGGAAALTAGHIASTYGGPSLQYRGSFTTGTPTAVELTALGMTPDNRTANPGALNAYHAYLLDGLLQVAPQIDRVLSDTGRARVAVAREQCLGELAATLDGADSGSMFTAPLTSVPGIWAVLYDYLGVPRRSFSQPLMLGHGSEDRDVPYLTTLLYAAGLALRGEPVAFRRYPVDHRGTLDAAAADGLAFVRARLGDGHFDEAAETAGLEQLLDDVR
>NC_015947.1|WP_014038260.1|3535130_3536765_-|NAD+-synthase
MASIRIAMAQFDFPVGDVAGNTERIIEMIGQARDEYGAELVMFPELAVSGYPPEDLLLRPGFLYECEQAMARIATACRGITAVVGWPQAAGAVVYNAASVLRDGLVEQTYRKRELPNYAVFDERRYFDVDPDGGSCVFEVNGIPVGLLICEDLWFAEPLADTMRAGAQLVVVPNASPYERGKHAQRDAVLAARTRESGAAIAYLNVVGGQDALVFDGASVVADGDGTVHPAAAAFVDQWLVVEYDGETRRFMPHVWMDDGDESMDALAWRAVTRGIQDYCRKNGFKKVWLGLSGGIDSAIVLAMAVDAMGAENVTAVRLPSRYTAGLSNDLAAEQCQALGVKLEAVSIEPAFKGLMEALAPMFEGTAPDVTEENLQSRSRGVILMALANKFGGLLLTTGNKSEYAVGYATIYGDMCGGYAPLKDLYKTEVFGLSKWRNTVGGAPVIPPAVISRPPSAELRENQLDQDSLPAYDVLDGILYRYIDQEQSRTEIVAAGYDAAVVDRVLRLVRISEWKRHQAAPGPKVSRRAFGRERRYPISNGYKG

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Crispr_ID: NC_015947_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015947_11

3554621-3554738

Orphan

Consensus_repeat	Method
AAGCAAATCCACGCATGGCGTGGATCTACT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015947_11

>merge|NC_015947|11|3554621-3554738|CRISPRCasFinder
AAGCAAATCCACGCATGGCGTGGATCTACTGGACGGTTTGGTTGCCGGCCAGCGGCCGGCACTACCGAAGCCAATCCACGCATGACCGAAGCGAATCCACGCATGGCGTGGATCTACT

>NC_015947|11|11|3554621-3554738|CRISPRCasFinder
AAGCAAATCCACGCATGGCGTGGATCTACT	GGACGGTTTGGTTGCCGGCCAGCGGCCGGCACTACCGAAGCCAATCCACGCATGACCG
AAGCGAATCCACGCATGGCGTGGATCTACT

Protein	Signature genes	Signature genes Name	Protein_function
NC_015947.1\|WP_014038276.1\|3561325_3561706_-\|DUF805-domain-containing-protein	unknown	unknown	gnl\|CDD\|377540
NC_015947.1\|WP_014038275.1\|3560672_3560891_-\|hypothetical-protein	unknown	unknown	unknown
NC_015947.1\|WP_014038262.1\|3541145_3542519_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225114
NC_015947.1\|WP_014038263.1\|3542791_3544522_-\|type-IV-A-pilus-assembly-ATPase-PilB	unknown	unknown	gnl\|CDD\|274186
NC_015947.1\|WP_157355595.1\|3548873_3549458_-\|hypothetical-protein	unknown	unknown	unknown
NC_015947.1\|WP_014038264.1\|3544746_3545154_-\|pilin	unknown	unknown	gnl\|CDD\|227304
NC_015947.1\|WP_075676409.1\|3555612_3556983_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NC_015947.1\|WP_005418651.1\|3559665_3560544_-\|30S-ribosomal-protein-S6--L-glutamate-ligase	unknown	unknown	gnl\|CDD\|182468
NC_015947.1\|WP_014038261.1\|3539471_3541085_+\|PAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|236901
NC_015947.1\|WP_004154430.1\|3537896_3539066_-\|ADP-forming-succinate--CoA-ligase-subunit-beta	unknown	unknown	gnl\|CDD\|234813
NC_015947.1\|WP_014038277.1\|3562138_3563992_-\|autotransporter-domain-containing-esterase	unknown	unknown	gnl\|CDD\|238883
NC_015947.1\|WP_014038265.1\|3545257_3545671_-\|pilin	unknown	unknown	gnl\|CDD\|227304
NC_015947.1\|WP_014038273.1\|3558361_3558832_-\|hypothetical-protein	unknown	unknown	unknown
NC_015947.1\|WP_014038267.1\|3548169_3548781_+\|dephospho-CoA-kinase	unknown	unknown	gnl\|CDD\|234620
NC_015947.1\|WP_014038278.1\|3564199_3564400_+\|sulfur-carrier-protein-ThiS	unknown	unknown	gnl\|CDD\|168159
NC_015947.1\|WP_005418626.1\|3547294_3548158_+\|prepilin-peptidase	unknown	unknown	gnl\|CDD\|224900
NC_015947.1\|WP_014038274.1\|3558927_3559407_-\|hypothetical-protein	unknown	unknown	unknown
NC_015947.1\|WP_014038266.1\|3546027_3547287_+\|type-II-secretion-system-F-family-protein	unknown	unknown	gnl\|CDD\|224376
NC_015947.1\|WP_014038272.1\|3557784_3558246_-\|hypothetical-protein	unknown	unknown	unknown
NC_015947.1\|WP_005410804.1\|3556945_3557623_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816

Protein	Function_ID	Function_description	E-value
NC_015947.1\|WP_014038276.1\|3561325_3561706_-\|DUF805-domain-containing-protein	gnl\|CDD\|377540	pfam05656, DUF805, Protein of unknown function (DUF805). This family consists of several bacterial proteins of unknown function.	2.01554e-19
NC_015947.1\|WP_014038262.1\|3541145_3542519_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	0
NC_015947.1\|WP_014038263.1\|3542791_3544522_-\|type-IV-A-pilus-assembly-ATPase-PilB	gnl\|CDD\|274186	TIGR02538, Type_IV_pilus_assembly_protein_PilF, type IV-A pilus assembly ATPase PilB. This model describes a protein of type IV pilus biogenesis designated PilB in Pseudomonas aeruginosa but PilF in Neisseria gonorrhoeae; the more common usage, reflected here, is PilB. This protein is an ATPase involved in protein export for pilin assembly and is closely related to GspE (TIGR02533) of type II secretion, also called the main terminal branch of the general secretion pathway. Note that type IV pilus systems are often divided into type IV-A and IV-B, with the latter group including bundle-forming pilus, mannose-sensitive hemagglutinin, etc. Members of this family are found in type IV-A systems. [Cell envelope, Surface structures, Protein fate, Protein and peptide secretion and trafficking].	0
NC_015947.1\|WP_014038264.1\|3544746_3545154_-\|pilin	gnl\|CDD\|227304	COG4969, PilA, Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion].	6.50262e-20
NC_015947.1\|WP_075676409.1\|3555612_3556983_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	5.19482e-50
NC_015947.1\|WP_014038261.1\|3539471_3541085_+\|PAS-domain-containing-protein	gnl\|CDD\|236901	PRK11360, PRK11360, two-component system sensor histidine kinase AtoS.	3.20901e-38
NC_015947.1\|WP_004154430.1\|3537896_3539066_-\|ADP-forming-succinate--CoA-ligase-subunit-beta	gnl\|CDD\|234813	PRK00696, sucC, ADP-forming succinate--CoA ligase subunit beta.	0
NC_015947.1\|WP_014038277.1\|3562138_3563992_-\|autotransporter-domain-containing-esterase	gnl\|CDD\|238883	cd01847, Triacylglycerol_lipase_like, Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases. Members of this subfamily might hydrolyze triacylglycerol into diacylglycerol and fatty acid anions.	1.05977e-65
NC_015947.1\|WP_014038265.1\|3545257_3545671_-\|pilin	gnl\|CDD\|227304	COG4969, PilA, Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion].	2.94075e-23
NC_015947.1\|WP_014038266.1\|3546027_3547287_+\|type-II-secretion-system-F-family-protein	gnl\|CDD\|224376	COG1459, PulF, Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion].	6.74149e-154
NC_015947.1\|WP_014038267.1\|3548169_3548781_+\|dephospho-CoA-kinase	gnl\|CDD\|234620	PRK00081, coaE, dephospho-CoA kinase; Reviewed.	1.06586e-85
NC_015947.1\|WP_005418626.1\|3547294_3548158_+\|prepilin-peptidase	gnl\|CDD\|224900	COG1989, PulO, Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion].	4.39586e-59
NC_015947.1\|WP_014038278.1\|3564199_3564400_+\|sulfur-carrier-protein-ThiS	gnl\|CDD\|168159	PRK05659, PRK05659, sulfur carrier protein ThiS; Validated.	6.97759e-31
NC_015947.1\|WP_005410804.1\|3556945_3557623_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.28625e-73
NC_015947.1\|WP_005418651.1\|3559665_3560544_-\|30S-ribosomal-protein-S6--L-glutamate-ligase	gnl\|CDD\|182468	PRK10446, PRK10446, 30S ribosomal protein S6--L-glutamate ligase.	1.48133e-125

>NC_015947.1|WP_157355595.1|3548873_3549458_-|hypothetical-protein
MADIGCHNLESFFLLFDSHELSDNAWPGNIQDGHFDGEDCTGVLRLYLAGGMLEAGGGPLRSGFPSLPAHFPRSTVPTVPGRRLDGVAAGRLSFAVLTGLSHSVGSKQLSAQLLVLKDTDISYLPEVPERVPVSVCFEGVKSCVVRFDETAMEWNERLGNVASCIVDEKRGVCWLYLRNGIVVIEAHAGVMLFD
>NC_015947.1|WP_014038267.1|3548169_3548781_+|dephospho-CoA-kinase
MSRYVVGLTGGIAAGKSEVTRRFEALGIVVADADLAARAVVAAGSPALGRIAERFGAHMLQADGSLDRARLRAHVFADPAERTALEAITHPAIRLLMQQQCEQATSPYAIAAIPLLTEVGGRQAYPWLDRVLLVDAPEAVQHARLMQRDDIDAALADKMIAAQASRAQRLALADDVVVNDGHPEDLQAQVEALHERYLELAGG
>NC_015947.1|WP_005418626.1|3547294_3548158_+|prepilin-peptidase
MAFLDQHPGLGYPAAAALGLLLGSFLNVVILRLPKRLEWQWKRDAREVLEEPDFYEPPPPGIVVEPSHCPHCKHKLSWYENIPLFSWIIQGGKCRHCKAPISLQYPLVEALTSVLVLACVWQFGFGWQGFGAIVLTCFLIALSGIDLRTQLLPDQLTLPLMWLGLIGNIDNLYMPAKPALVGAAVGYLSLWMVWWLFKQLTGKEGMGHGDFKLLAALGAWCGLKGILPIILLSSVLGAIIGSIWLYTRGRDRATPIPFGPYLAIAGWLYFMWGAPVVEQYLVLSGLR
>NC_015947.1|WP_014038266.1|3546027_3547287_+|type-II-secretion-system-F-family-protein
MSVSRSAIKKEPVARSTTELQPFVWEGTDKRGVKMKGEQAAKNANLLRAELRRQGITPGAVKPKPKPLFGAAGSKISPKDIAFFSRQMATMMKSGVPIVGALDIIASGHKNPRMKKMVESVRTDIEGGSSLYEAVSKHPVQFDELYRNLVRAGEGAGVLETVLDTVATYKENIEALKGKIKKAMFYPAMVLAVALLVSGILLVWVVPQFEDVFKGFGADLPAFTQMIVNMSRFMVSWWWLILLIIIGSIVGFIAAYKRSPKMQHSMDRLVLKLPVIGQIMHNSSIARFARTTAVTFKAGVPLVEALGIVAGATGNTVYEHAVLRMRDDVSVGYPVNMAMKQTALFPHMVIQMTGIGEEAGALDAMLFKVAEYYEQEVNNAVDALSSLLEPIIMVIIGTIVGGMVIGMYLPIFKLASVVG
>NC_015947.1|WP_014038265.1|3545257_3545671_-|pilin
MKNQKGFTLIELMIVVAIIAILAAIALPMYQDYVAKSQATAGLAEITPGKTQFEVAINEGKTSADIKDIAAIGLKSSDRCTITMTFAETGNIVCTLKGSPKLTASKGAITLTRATDGTWACTSGVDAKYLPSGCKAP
>NC_015947.1|WP_014038264.1|3544746_3545154_-|pilin
MLKQRGFSLIELMIVVAILAVLAAISLPMYQNYIAKSQLAAAFAEIRPGKTTVETVVQDSRDTGLVDASYIGLKPSSICSVVTAELNASGIGSITCTVGGGPAIRGKELVLRRAADGTWTCDGSAFEARYRPTGC
>NC_015947.1|WP_014038263.1|3542791_3544522_-|type-IV-A-pilus-assembly-ATPase-PilB
MNAVTTANLVGITGLARRLVQDGALDEASARDAMAKAAAARQPLPTWFAQNKVVGAAQLAAANAVEFGMPLFDVSTFDASQNAMSLVSEELLRKHNVLPLFKRGGKLFVGTSNPTHSLDEIKFHTNLVVEPILVDEDQIRRTFEQWHASHDTLGDALSGDDDGMGNLDVAAGDEDLGAGGDSGIDAKGDDTPVVKFVNKVLVDAIRKGASDIHFEPYEDDYRVRLRIDGLLKMVARAPVKLNQRIAARLKVMAQLDIAEKRVPQDGRIKLNLSKTKQIDFRVSTLPTLFGEKVVLRILDGSAAKLGIDKLGYEPDQQKLFLEAIHKPYGMVLVTGPTGSGKTVSLYTALGILNDETRNISTAEDPVEIRLPGVNQVQQNNKRGMTFAAALRSFLRQDPDIIMVGEIRDLETAEIAIKAAQTGHMVLSTLHTNDAPQTIARLMNMGIAPYNITSSVTLVIAQRLARRLCNNCKRPSNLPEHALLAEGFTQAQLDAGIELYEAVGCDECTEGYKGRTGLYQVMPMTDEIATIVLAGGNALQIAEAAQQIGVNDLRQSALKKAAAGVTSLAEINRVTKD
>NC_015947.1|WP_014038262.1|3541145_3542519_+|sigma-54-dependent-Fis-family-transcriptional-regulator
MNETRSALVVDDERDIRELLVLTLGRMGLRISTAANLAEARELLASNPYDLCITDMRLPDGNGIELVSEIAQHYPRTPVAMITAFGSMDLAVEALKAGAFDFVSKPVDIAVLRGLVKHALELNNTERPAPGPAAEQGARLLGDSPAMDVLRTTIGKVARSQAPVYILGESGVGKELVARTIHAQGARAAGPFVPVNCGAIPGELMESEFFGHRKGSFSGAHADKPGLFQAAHGGTLFLDEVAELPLQMQVKLLRAIQEKSVRAVGAANEEPVDVRILSATHKDLAELVEDGRFRHDLYYRINVIELKVPPLRERRQDLPELAASVLARLARSHGRPTPLLAPSALDALAQYAFPGNVRELENILERALALAEEDRIGADDLRLPQHAPRTPGSAAHAEAVVDLQPGSAALPSYIEQLERSAIQRALEENRWNKTRTAAQLGITFRALRYKLKKLGME
>NC_015947.1|WP_014038261.1|3539471_3541085_+|PAS-domain-containing-protein
MSPSASLIDRIESIPRRELYFFALYRVLIASVIAALLYSPLSAMVGEAHHPRLADTVAAIYLVLSLLALVIGRNERWLRPIVVSGVLVDIIAATLLSHALPGASAGISMSLLFNIAAAATLLPLSLGLGLALAASLATGVEYTWKLLEGGDPTRTLAELAMFATSYLALAFISYQVGSRARRNQQLANQRGDEVANLFQINELIIRRMRTGVLVVDADNRVTLANEAASMLLGDSDGSGESGRLDLASAAPELARRLQRWRNGWAQDELPLQLNPDQPEVQPRFARLLAGSELALVFLDDSSVVSRRAESLTLSAMGRFSASLAHEIRNPLAAINYAVQLLEEGTGFNESDRRLLQIIRQQCQRTNGIVESVLGLARRERATPENVDLAAFVRRFVLEYKQGQTLETDSIEPIINDTSVLAQVDTKHLYQVLTVLVHNALKYGRIGQQPARVRLRVAQHERSAVIDVMDRGPGIPESVAAQLFRPFFTTSEHGTGLGLYIARELCRANQARLDYIPVPAGGSCFRLVLPGPHTLLPT
>NC_015947.1|WP_004154430.1|3537896_3539066_-|ADP-forming-succinate--CoA-ligase-subunit-beta
MNFHEYQSKQLLAEYGIPVPAGKVAATPDEAVAAANSLGQGPWMVKAQIHAGGRGKAGGVKFCKTTDDVKAAAAKMLGTKMATYQTAGVELPVNLVLVTTAGEIVKELYLSVLVDRGTKTITYIASSEGGVEIEQVAAETPELIHSLNVDFVEGVQGYHGRDFGFKLGLTAKQAGQFASIMVNLYRLFNEKDLALVEINPLAILDDGNLYALDGKFDSDDNAAFRQKALVAMRDKTQEDPTEVIASELDINYVTMDGNIGCMVNGAGLAMATMDVIKLNGGEPANFLDVGGGANKQRVIEAFKLILSSDKVEGIFVNIFGGIVRCDMIAEGIIAAVKEVGVKVPVVVRLEGTNVEEGKQLLRDSGMAIIPADNINDGAKKIVEAVKNAA
>NC_015947.1|WP_075676409.1|3555612_3556983_-|HAMP-domain-containing-histidine-kinase
MASDTASPPRKPDSVATKGERRRSPYRRRLRSRIIVSFVLLGFCLTTLFAFATNWARMRVENQLVEDVMNRNINEYVRRFYESPDRNPDLPVQQMRARLVKPDKFDALREEEPDWAALPDGNHNISGTDERGQPYAYKLAVRKTPDAWAFLAYDMTDSVRGGQQLNRALVLSVLVFSLLSLVLGWWSASKVMKPVSDLAARLRAYRGGTSDPEPLAPRFPDDEVGQLAQALDDYSSRLTEVVQRDREFNADVSHELRTPLAVIRGATELLLTRPGLDEKVLQRLQRIQRAEQQCSDLIGALLLLSRNERGQGTSNVARVAEQLLDAHRAQLGGKPLELALEGERNLVIDAPEAALSVALGNLIGNAVKYSQDGEVRVFVGSNSVSVTDSGPGLSEEDAAKLFQRGYRGTHAGHSQGGGIGLSIVSRLCDLYGWQVSVRPGGERGVIATLTFSPKPL
>NC_015947.1|WP_005410804.1|3556945_3557623_-|response-regulator-transcription-factor
MRILVIEDNSDIAANLGDYLEDRGHTVDFAADGVTGLHLAVVHEFDAIVLDLNLPGMDGIEVCRKLRNEARKQTPVLMLTARDSLDNKLAGFDSGADDYLIKPFALQEVEVRLNALSRRGKGVQTRVLETGDLEYNLDTLEVRRQGKLLQLNPTALKILQALMEAAPAVVTRQELETRVWGEELPDSDSLRVHIHGLRAVVDKPFEVPLIQTRHGIGYRIATPEA
>NC_015947.1|WP_014038272.1|3557784_3558246_-|hypothetical-protein
MYRKTTLALMLSLGLVATVQAKAQKETVQMDSFTPVSEQIRRVETAMGSEDYSEIGLEDKSRVQQALNRIRIKMNGREKVDELAPQERNDLFNEQEIVNTIMTRAQADSRMICRRERLTGSNMPTSVCLTVAQRRKAQEDSRRALTDQQRISR
>NC_015947.1|WP_014038273.1|3558361_3558832_-|hypothetical-protein
MQRMTPVALMLGLALATTAHAKPEKGQVKFDANAPVAEQIRSVEAAINTEDYSEIGLEDKSRVQQALGRIKIKMGDHERVEQVSPQDRTEIFNDQEVINTIMTRAHADSRMVCRRERTTGSNMPQSVCLTVAQRRKAQEDSRKALNDNQRFNNYKP
>NC_015947.1|WP_014038274.1|3558927_3559407_-|hypothetical-protein
MYRIMTIALLLGLSGAVAAKPEKVAVQMDRQGAVAEQMRQVETALAAPDYAELSAEDRGQVQQSLSRIRQHMGERQTVQELPPQLQAEVFNEQERINTLLARGHEDSRQICRYERTTGSNMPKSRCLTVAERRRIEEKGKALINDQRSYNTLSPPPAGR
>NC_015947.1|WP_005418651.1|3559665_3560544_-|30S-ribosomal-protein-S6--L-glutamate-ligase
MKLAILSRNSSLYSTRRLVEAARARGHTVRILDPLRCYMRIAADGFSMHYKGRPMTGVDMVIPRIGASITRYGTAVLRQFELMGARTPNPSDAILRSRDKLRAHQLLAAKGIDMPVTVFGDNPDDTVDLLSMLGPPPHVVKLNEGTQGRGVILTEKASASRGIVEALRGLYANFLMQEFIGEAKGADLRCFVVGDQVVASMQRQAPEGDFRSNLHAGGTAVAAKASRAEQQVAVRSAKALGLSVCGVDLIRSARGPLVLEVNSTPGLEGIEAACGVDVATRIIEHVEKIKKP
>NC_015947.1|WP_014038275.1|3560672_3560891_-|hypothetical-protein
METKDDVVGSLHEIYRNSGAGTSRQLEALRALGRAGGPKAAQLLWQIYKSTSAGSAAQMVCIAALGESARGF
>NC_015947.1|WP_014038276.1|3561325_3561706_-|DUF805-domain-containing-protein
MIAALAPLRRCLDFSGRSDRIEFWSFSLLGLLVAGLSYSLMNIGYWLIGTDLFDWELSRQLGILGQVLAIITVLVFLPPMLALAVRRLHDIDESGWYVVIAFIPLGVFVLFPVMLLPGSEEENRFG
>NC_015947.1|WP_014038277.1|3562138_3563992_-|autotransporter-domain-containing-esterase
MLLSKRPIRSLMAAAIALAALPAMAGESPYSKAVFFGDSLTDAGYFRPLLPAGVQPVTGQFTTNPGWVWSQQVANYYGVNGAPNGNGQNGDNYAVGGARVSVDEAGGLGVIPSLKSQATRYLAANGGKADANALYTVWGGANDLFAATRAAAGGASQAQVQGIIGAAVTDQIALVGALKQAGAQYVLVPNLPDVGITPQFRGPNAAAATALSAGYNKALYGGLKQAGIEFIPLDTFSILREVTANPAMYGFTNVTSTACKIDPANSTQSILTCNPTSYVSPDAANTYLFADGVHPTTAGHQLLGQYAVSVLEGPRLQQVLSHSAQTIGRSRADQVSMHLGGRPADGLSWWGGVRGDLQRYDHADLYDGLAPAGLFGIDWARDGMVFGGFAGFGRLNADFGNSRGDFTQKDTTAGLFAGWYGDRIWVNGQVSYTWLSYDVNRKVQLGPATREHGGSPDGSNLTAALNAGYEFGTEGGFRHGPIASVIWQKVKIDGYTESAAAGTLATALGYDRQNVDSTVGRIGWQARFDGGTVKPYAQVTYDHEFEDTKQASAWLQTLPELGNYRVPGLNFDKNYATVVLGARTELFGLQSNFGLSASTGQKRAQDATLFANFSGTF
>NC_015947.1|WP_014038278.1|3564199_3564400_+|sulfur-carrier-protein-ThiS
MNIQLNGEPRTLPASATLHDLLLAEQLLQRRVAVEVNGEIVSRSRHGEHVLAEGDVVEIVHALGGG

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Crispr_ID: NC_015947_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015947_12

4098614-4098715

Orphan

Consensus_repeat	Method
GCCACCCGACCAACGGTCGGGCGCTACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015947_12

>merge|NC_015947|12|4098614-4098715|CRISPRCasFinder
GCCACCCGACCAACGGTCGGGCGCTACCGGTCCGGCTTGGTGGGTGCCGACCGTTGGTCGGCACACCTTTCAATGCCACCCGACCAACGGTCGGGTGCTACC

>NC_015947|12|12|4098614-4098715|CRISPRCasFinder
GCCACCCGACCAACGGTCGGGCGCTACC	GGTCCGGCTTGGTGGGTGCCGACCGTTGGTCGGCACACCTTTCAAT
GCCACCCGACCAACGGTCGGGTGCTACC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015947.1\|WP_005411275.1\|4100965_4101295_+\|thioredoxin	unknown	unknown	gnl\|CDD\|200072
NC_015947.1\|WP_005411271.1\|4095148_4095991_-\|response-regulator	unknown	unknown	gnl\|CDD\|381085
NC_015947.1\|WP_014038698.1\|4090082_4090961_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|234578
NC_015947.1\|WP_080011123.1\|4092730_4093120_-\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl\|CDD\|368831
NC_015947.1\|WP_006473441.1\|4093284_4094160_-\|RNA-polymerase-sigma-factor-RpoH	unknown	unknown	gnl\|CDD\|235838
NC_015947.1\|WP_014038711.1\|4108358_4108775_-\|roadblock/LC7-domain-containing-protein	unknown	unknown	gnl\|CDD\|214939
NC_015947.1\|WP_014038713.1\|4109311_4110277_-\|hypothetical-protein	unknown	unknown	unknown
NC_015947.1\|WP_014038699.1\|4091019_4092303_+\|phosphoribosylamine--glycine-ligase	unknown	unknown	gnl\|CDD\|234856
NC_015947.1\|WP_014038712.1\|4108767_4109319_-\|GTPase	unknown	unknown	gnl\|CDD\|225138
NC_015947.1\|WP_014038705.1\|4097735_4098479_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NC_015947.1\|WP_014038703.1\|4095998_4096946_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|225088
NC_015947.1\|WP_014038708.1\|4103483_4105058_+\|sensor-domain-containing-diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635
NC_015947.1\|WP_014038700.1\|4092414_4092747_-\|DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225495
NC_015947.1\|WP_014038707.1\|4101522_4103274_+\|transcription-termination-factor-Rho	unknown	unknown	gnl\|CDD\|236490
NC_015947.1\|WP_014038702.1\|4094438_4095152_-\|uracil-DNA-glycosylase	unknown	unknown	gnl\|CDD\|235376
NC_015947.1\|WP_005419760.1\|4107945_4108305_-\|hypothetical-protein	unknown	unknown	unknown
NC_015947.1\|WP_014038710.1\|4106068_4107799_-\|bifunctional-isocitrate-dehydrogenase-kinase/phosphatase	unknown	unknown	gnl\|CDD\|235089
NC_015947.1\|WP_014038706.1\|4098734_4100456_-\|ATP-dependent-RNA-helicase-RhlB	unknown	unknown	gnl\|CDD\|235307
NC_015947.1\|WP_014038709.1\|4105097_4105988_-\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|367555
NC_015947.1\|WP_014038704.1\|4096949_4097636_-\|cell-division-ATP-binding-protein-FtsE	unknown	unknown	gnl\|CDD\|225438

Protein	Function_ID	Function_description	E-value
NC_015947.1\|WP_005411275.1\|4100965_4101295_+\|thioredoxin	gnl\|CDD\|200072	TIGR01068, Thioredoxin-like_protein_slr0233, thioredoxin. Several proteins, such as protein disulfide isomerase, have two or more copies of a domain closely related to thioredoxin. This model is designed to recognize authentic thioredoxin, a small protein that should be hit exactly once by this model. Any protein that hits once with a score greater than the second (per domain) trusted cutoff may be taken as thioredoxin. [Energy metabolism, Electron transport].	3.61254e-46
NC_015947.1\|WP_005411271.1\|4095148_4095991_-\|response-regulator	gnl\|CDD\|381085	cd00156, REC, phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs). Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.	1.68384e-16
NC_015947.1\|WP_014038698.1\|4090082_4090961_+\|hypothetical-protein	gnl\|CDD\|234578	PRK00022, lolB, lipoprotein localization protein LolB.	0.00483184
NC_015947.1\|WP_080011123.1\|4092730_4093120_-\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl\|CDD\|368831	pfam06296, RelE, RelE toxin of RelE / RelB toxin-antitoxin system. RelE is a family of Gram-negative bacterial antitoxins of the RelE/RelB toxin-antitoxin system. Its cognate antitoxin is family RelB, pfam04221.	4.02681e-50
NC_015947.1\|WP_006473441.1\|4093284_4094160_-\|RNA-polymerase-sigma-factor-RpoH	gnl\|CDD\|235838	PRK06596, PRK06596, RNA polymerase factor sigma-32; Reviewed.	3.03668e-175
NC_015947.1\|WP_014038711.1\|4108358_4108775_-\|roadblock/LC7-domain-containing-protein	gnl\|CDD\|214939	smart00960, Robl_LC7, Roadblock/LC7 domain. This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.	2.92092e-10
NC_015947.1\|WP_014038699.1\|4091019_4092303_+\|phosphoribosylamine--glycine-ligase	gnl\|CDD\|234856	PRK00885, PRK00885, phosphoribosylamine--glycine ligase; Provisional.	0
NC_015947.1\|WP_014038712.1\|4108767_4109319_-\|GTPase	gnl\|CDD\|225138	COG2229, COG2229, Predicted GTPase [General function prediction only].	2.54102e-26
NC_015947.1\|WP_014038705.1\|4097735_4098479_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	8.73685e-22
NC_015947.1\|WP_014038703.1\|4095998_4096946_-\|ABC-transporter-permease	gnl\|CDD\|225088	COG2177, FtsX, Cell division protein [Cell division and chromosome partitioning].	4.20687e-74
NC_015947.1\|WP_014038708.1\|4103483_4105058_+\|sensor-domain-containing-diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	4.23794e-59
NC_015947.1\|WP_014038700.1\|4092414_4092747_-\|DNA-binding-transcriptional-regulator	gnl\|CDD\|225495	COG2944, COG2944, Predicted transcriptional regulator [Transcription].	4.81818e-29
NC_015947.1\|WP_014038707.1\|4101522_4103274_+\|transcription-termination-factor-Rho	gnl\|CDD\|236490	PRK09376, rho, transcription termination factor Rho; Provisional.	0
NC_015947.1\|WP_014038702.1\|4094438_4095152_-\|uracil-DNA-glycosylase	gnl\|CDD\|235376	PRK05254, PRK05254, uracil-DNA glycosylase; Provisional.	8.86919e-150
NC_015947.1\|WP_014038710.1\|4106068_4107799_-\|bifunctional-isocitrate-dehydrogenase-kinase/phosphatase	gnl\|CDD\|235089	PRK02946, aceK, bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated.	0
NC_015947.1\|WP_014038706.1\|4098734_4100456_-\|ATP-dependent-RNA-helicase-RhlB	gnl\|CDD\|235307	PRK04537, PRK04537, ATP-dependent RNA helicase RhlB; Provisional.	0
NC_015947.1\|WP_014038709.1\|4105097_4105988_-\|TonB-dependent-receptor	gnl\|CDD\|367555	pfam03544, TonB_C, Gram-negative bacterial TonB protein C-terminal. The TonB_C domain is the well-characterized C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance.	3.50568e-09
NC_015947.1\|WP_014038704.1\|4096949_4097636_-\|cell-division-ATP-binding-protein-FtsE	gnl\|CDD\|225438	COG2884, FtsE, Predicted ATPase involved in cell division [Cell division and chromosome partitioning].	2.8624e-112

>NC_015947.1|WP_014038705.1|4097735_4098479_-|class-I-SAM-dependent-methyltransferase
MASVPSYDAFDLHYAQHVAASASRPLERRTLLELAGPLQGRDVIDLACGSGDFGRHLLLHGARSALGVDLSAAMIEQARRLSGQGGDAMQFLHGDATRLDLPARFDIAVAVWLFNHADTLQELERMYRAAAHVLRPGGRLLGIVTHPAFRLARGDFSRYGARIVRQQALEDHHLVEVAFADAAVARVTDHQWRADQHEQAAARAGLPGLQWQVPAPTAAECEGRPAGFWDEYRDNNALVVLHARREG
>NC_015947.1|WP_014038704.1|4096949_4097636_-|cell-division-ATP-binding-protein-FtsE
MSVLRFDNVSKQYAGGHEALIDVSFEVAPGEMLFVTGHSGAGKSTLLKLIHLDERPSRGAVMFDERNLLKVRGGDVPRHRRAVGAVYQDHRLLMDRSIAENVALPLILRGTRRGDISKRVRSVLERMGLGHREKALPSQLSAGEQQRVGIARAIVGEPKLLVADEPTGNLDPTLAAEIMALFAELPSRGTSVLVVSHDLPLLRRMRKRVLILDHGRLVDDISPQDLAE
>NC_015947.1|WP_014038703.1|4095998_4096946_-|ABC-transporter-permease
MAKNENSEAAAPSRVGVWFQHHVHSVVFSLGRACRKPWATLLTVMVMALALALPLGLSIALDNLKQFAGSVQQSRDINVFLKGNVDGPGALRLAGQLRDRDDVAEVNVRTPEQGLQELRDAGLGEAIDALNDNPLPSLLVITPGQGKDDARLARALESLPEADLVQHDALWRQRLDAWLAFGARLVQVLSVLLGVGAALVVGNTVRLDIQARREEIGVLQLLGASDGFIRRPFLYLGAWYGLGAGAVALALIGAAGAALRMPLAELSRSYGSPFVLHGLDLLHGGLVLLGTLLLGWLGAWLVTGHFLRQTRPTDT
>NC_015947.1|WP_005411271.1|4095148_4095991_-|response-regulator
MQPQALKHLEGPATRVMVVDGSKLVRKLIADVLQRDLPGVEVIGCDSIEDAQQALAQGPVDLVTTSLTLRDGDGLALARMVREAAGQAYVPVIVVSGDAQQHLEQRRFTEYVTDYFDKALGHEALATFIRGYVQPQTIPGATILYIEDSRVVAEATKRMLERQQLNVLHVVSAEEAFTLLTAESLGRSRHRIDLVLTDVTLKGELSGRDVVQRVRVDFGYGKRRLPVLVMTGDGNPHNQTGLLQSGANDLVLKPIEERLLVTKVLFQLRLARLNDGPLIR
>NC_015947.1|WP_014038702.1|4094438_4095152_-|uracil-DNA-glycosylase
MMDEVADTPTIQLEPSWKQHVGDYLLQPQMRELSSFLRQRKASGAAVFPPGPQIFAAFDATPFEQVKVVILGQDPYHGRGQAHGLSFSVAPGVPVPPSLLNIYKEIESDLGIPRPDHGCLIPWAQRGVLLLNAVLTVEEGKAGAHQGRGWEGFTDHVVDVLNREREGLVFMLWGAYAQQKGKVIDTRRHRVLKSPHPSPLSAHRGFLGCRHFSMANEYLQRRGQAPIDWSLPPRSAL
>NC_015947.1|WP_006473441.1|4093284_4094160_-|RNA-polymerase-sigma-factor-RpoH
MSQNTSTALVANNLPIPSALGSLDAYIGAVHQIPVLSVDDEQDLARRFRDGNDLDAARELVHSHLRFVVHVARGYNGYGLALGDLIQEGNIGLMKAVKRFDPDMGVRLVSFAVHWIRAEMHEFILKNWRIVKVATTKAQRKLFFNLRKSKTRLGWMNAAEVSAVAKDLNVSEREVMEMESRLSGRDIGFDAPTDEDNEHAPPSPAAFLVANDEDPSMAYERADSEDNQMQLLREGLAELDARSRDIIRRRWLDADSKVTLQELADEYGVSAERIRQVEANALKKMKALFTA
>NC_015947.1|WP_080011123.1|4092730_4093120_-|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MIMPRVFRTRSFNRSMRRTTLSDAALYRSVREMEAGLVDADLGGGILKKRVALPGRGKRGSVRTIVATQRGGHWFFLFGYEKNERAAITNAERDALQLYASEFLKMSTAQLNRAVQYGDLQEISHDEDP
>NC_015947.1|WP_014038700.1|4092414_4092747_-|DNA-binding-transcriptional-regulator
MTKTPERRRAKSALLEAVHDAAVSLHAHGFIDKRRLSSYEALCLEPVPEYSSAQIRALRASLQLSQPVFAGVLNTSVSTVRSWEQGEKKPSGPSLKLLNLIDRKGLEAVL
>NC_015947.1|WP_014038699.1|4091019_4092303_+|phosphoribosylamine--glycine-ligase
MNVLVIGSGGREHALAWKLAQSSRVTEVIVAPGNAGTASEDKCRNVAVKVTDIDGLLALAQAEGVALTVVGPEVPLVAGVVDRFRAAGLRIFGPTAAAAQLEGSKAYAKDFLARHNIPTAFYAVHTEVDAALAYIREKGAPIVVKADGLAAGKGVIVAMTLAEAEDAVRDMLSGNAFGDAGARVVIEEFLDGEEASFISMVDGVHALPMATSQDHKRVGDGDTGPNTGGMGAYSPAPVVTPEVHARVMREVVNPTVQGMIADGIPFTGFLYAGLMIDASGAPKVIEFNVRFGDPETQPVMLRLQSDLVELVEAAIDGRLDQVEAHWDARPSLGVVLAARPYPESPITGDVISGLDDVPASAKVFHAGTALDAQGQVLSAGGRVLCVAALGDSVRDAQANAYAGVAKVSWANEFHRNDIGWRAIAREG
>NC_015947.1|WP_014038698.1|4090082_4090961_+|hypothetical-protein
MSTVSMKSLAALALAGAAVLAGCKPAAETSAGPKAEAPAVAPTSPAQHASRTARLQAFLVQRYGSNAKLSGEWRGSWTDDGDTHAMDWQVCAEQPVVSGDSWQQLLAVCGALVDGAHIDPGTIEFFVLRPKGESFEVTSELTGERFGSGGQPGTASIIRAGSDFYGFRVEDGWFGQGFSLLSQSLILSGPNGLVASGSVRSHIDNDAQYECDAVDASTDPDTAIDCRTRRFSIDFALHFDDSDRSARVWPLLIEETGTTCGGKQVRQEHRFTLDPNTWAYSFPESLRREGCE
>NC_015947.1|WP_014038706.1|4098734_4100456_-|ATP-dependent-RNA-helicase-RhlB
MSDKPLTDLTFSSFELHPALQAGLEGAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVVNRLLTRPALADRKPEDPRALILAPTRELAIQIHKDAVKFGSDLGLRFALVYGGVDYDKQRELLQQGVDVIIATPGRLIDYVKQHKVVSLHACEICVLDEADRMFDLGFIKDIRFLLRRMPERTIRQTLLFSATLSHRVLELAYEHMNEPQKLVVEAETITAARVRQRIYFPADDEKIPLLLGLLSRSEGARTMVFVNTKVFVERVARSLEKAGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATDVAARGLHIDGIKYVYNYDLPFDAEDYVHRIGRTARLGEEGDAISFACERYAMGLPDIEAYIEQKIPSEPVTKELLTPLPRPERPAPAAGEEGEENESVGQIFREAREARAAEEERRGGGRSGGRSGGGRGERRDGERSGERRSRGPRKPRVEGEQAAVAPAEGAEAAVAQAPRPPRPPRAEGAPEGAVDGERKPRKRRRRRHGRPVEGGEGVQANAGNGASPVTPVQVVAKPVRTAADTGDSFLTRIGRKIRRMLSGS
>NC_015947.1|WP_005411275.1|4100965_4101295_+|thioredoxin
MSDKVVHVGDADFDSAVLNSKEPVLVDFWAEWCGPCKMIAPALDELADAYQGRAKIAKVNVDHNRALAAKYHVRSIPYLVVFKDGEKVGEQIGAVGKAQLAGLLDKALA
>NC_015947.1|WP_014038707.1|4101522_4103274_+|transcription-termination-factor-Rho
MSDNTSETGSADAPAEKRVRKPRVSKAAAPAAAETSAAPAQPTLPLAAAPEAPAPAAAAPAPSAPATEAPASGGGEGGEGRESGQRQQNHQGGGQNQGQGQGQNNNPYNQNGQQGQGNRRDRFRNRRDRDRNRGGRDDGMPQDGGEQQPFVPRPHANVPEGFPVYSLSDLKRMPAQKLLEIAEQLQISEGVARARKQDVIFALLKVLTRHGDGVAADGVLEILPDGFGFLRAAEASYLAGPDDTYISPSQIRRFNLRTGDHISGRIRFPKDGERYFALNIVDTINGEPIEASKNKVLFENLTALFPRRRFTLERGNGSSEDITGRILDLMAPQGKGQRSLIVSQPKAGKTMMMQQVATAITTNHPDVHLIVLLIDERPEEVTEMQRTVRGEVISSTFDEPAARHVQVAEMVIERAKRLVEHKKDVVILLDSITRLARAYNNVVPSSGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALVDTGSKMDEVIYEEFKGTGNSEVHLSRRIAEKRVFPAIDINRSGTRREDLLIEPELLQKIWILRKLLHPMDEMAAMEFLLDKMKNTKSNDEFFGSMKR
>NC_015947.1|WP_014038708.1|4103483_4105058_+|sensor-domain-containing-diguanylate-cyclase
MRTLSPRLNLGKLILALALLSAIIALANTLLASYRVQRDQLVGNTLEANRVYATKLAETTQNFLLAAQQELAYAATRLGQSDLDPKQAQDEASRLQLQTNSFNSSLVVDADGLVIATSPQTLQLQGEILHSVGNNAALAARQPMISDPYQSATGKLLVSLSHPIFDRQGRYRGYVSGTLYLRQRSALHTLLGKHYYRDGSYLYVVDRHGRLLYHADGKRVGDYVVGNPAVKTVVRGERGAQQVRNNLGVSMLAGYAPVPATGWGIIAQRPTEATLQPLSRLMTAVIWNAIPLGLLSLLITWWFARRISMPLWQLARNVQGGEDTGNAINHVSGIRAWYFEVAQLKQAVLHSFNALQDRIGTLNRANRTDPLTGLLNRRGLQQALDALQVQGIPFAILALDIDRFKSINDSHGHDVGDAAIVHIADQMRRYSRDSDILCRAGGEEFLLLLPGISTDSARQAGERLRQHIADHPFEPVGTITVSLGVAHFPSFHVDAEQALRLADKALYMAKEQGRNRVVVYPYAD
>NC_015947.1|WP_014038709.1|4105097_4105988_-|TonB-dependent-receptor
MMRSPLFLALALAFTAGAPLLPADAVAQNARAVRATAEMSMALSGSIDVAADGSVSKLTLDQQAMLAPGIASFVEGAIRGWQFEPTLRDGKPVAAHAPLRVRLRGKEQDDGSYQISMTSVDFSEYDPKATDSVTRKNMPPPRYPEDAFRNGGQGDVLLLVQVARDGTVADVIAEQVNMTVVAPERTMAKMRDILAKASISAARKWTFVPPTTGEDSTRDSWTVRVPVTFALNNSDNGQPERYGRWRAFIPGPRQAAPWRKPDAAEQAGSDLLPAGGVYMVDGTQRGLRLLTPLAQR
>NC_015947.1|WP_014038710.1|4106068_4107799_-|bifunctional-isocitrate-dehydrogenase-kinase/phosphatase
MSEPDIAAELASRIAGAIHAGFEQYHARFAAITARARQRFEQRDWAAARQDAVERIALYDLCIAEQMDALRRLAGEAIGERALWLQVHARYSALLRGLIDAELYKTFYNTLSRRLFSTRGVDPELEFIAFDVEPSDAITHPVARHTYAVSPTRPVEALQRVLADYRFDIPYAHQLRCAAAIAVRLQDDLAHWGDTPVRSIELLDTVFYRERRAYLVGRVFGEHRFSPCVIALVNDGQGLRADAVLTRRRDVAHLFGVSRSYFQADLATVGDAVVFLRSLLPGKPIDEIYTVLGRAKQGKTERYRTFFRHFNEHPQERLVPAEGTPGMVMAVFTLPSYPLVFKLIRDRFAWPKSMSRQQVEEKYALVFNLDRVGRLLDAQPYRHLRFPRDRFAPALLEELLAQCAQSVRVDGDQVEVALCYVQRRFRPLNLYLREQGGDAVRAAVLDYAQAITDMARNNIFPGDMLPKNFGVSRHGRAVFYDYDELCLVSDCVFRAWPQPRTPEEAMADEPWFHVGPRDVFPERFGPFMGLPAGELAAVREHYRHLFDPAWWQGLQARFAGGDYPDTPPYAVAHRLA
>NC_015947.1|WP_005419760.1|4107945_4108305_-|hypothetical-protein
MAGLNESLNALMGIDGAQAVALVDYESGMLLGEAGAGMDMEVAAAGNTEVIRAKMKTAASLNLNDSIEDILISLGKAYHIMRPVAKKKGLFFYIVLDRTKSNLALARRKVQDVEAELAI
>NC_015947.1|WP_014038711.1|4108358_4108775_-|roadblock/LC7-domain-containing-protein
MADGQMVVLPDAGQRERLQPLLQDLQQRVEGVRTVVLASVDGFALVSAGAEGRGERLAAMTSAMLALAAAVGRELVLGDLQTLMLEAAGGKVLMLAIQAEGRAPLLLMAACDQRSVIGQVLWQSRECGQAILAELGGS
>NC_015947.1|WP_014038712.1|4108767_4109319_-|GTPase
MREHKVVVLGGMGSGKSTLVRSIAAGAVIDTDVANSDRLGADKASTTVALDYADIDLPNGERLRLYGTPGQQRFDFLWPILLQGARGAVLLLDARRAGLASELEGYLQVLQPFASSSLALVVAVTHLDQAPQAVLDDWAARACLDGQPLPLLAVDARDREQGLLLMDVLMSEMEAHALVAAHG
>NC_015947.1|WP_014038713.1|4109311_4110277_-|hypothetical-protein
MARVLVVGTDIQGEQALLQRLRLASALPDGQVRRSQDLDDCDLLVIRDTPALRNAAQRMRQQRPRLQCWIEDIGGQLRDGDGHQDVLDDGAIGRALRRMQLAPEPLAMQTPAPIRLADGAHAITRLLRERLPLRQGQALLGDAGEPLLLMDLEHDQAVLLQEPAAALVERLADAFERLQLDALTPARLQALAGERPRQPLRPLLWQWAQRSRHWQALDERLRGASVKLLRWPDFRVLGHDHDGFRLCSLLLKRACTVEECAMLLELPAAAVRDFIHAAYLCGYAQLQAAPAAPMMATGGTRTDNGLLARLWRHLRGSERNA

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Crispr_ID: NC_015947_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015947_13

4157262-4157368

Orphan

Consensus_repeat	Method
CCTGCAGCCAGGCATGGCCTGGCTCTACT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015947_13

>merge|NC_015947|13|4157262-4157368|CRISPRCasFinder
CCTGCAGCCAGGCATGGCCTGGCTCTACTACAGGTTGCCTGGGAGGTAGTGCCGGCCGCTGGCCGGCAATCTCGCGAACCTGCAGCCAGGCATGGCCTGGCTCTACT

>NC_015947|13|13|4157262-4157368|CRISPRCasFinder
CCTGCAGCCAGGCATGGCCTGGCTCTACT	ACAGGTTGCCTGGGAGGTAGTGCCGGCCGCTGGCCGGCAATCTCGCGAA
CCTGCAGCCAGGCATGGCCTGGCTCTACT

Protein	Signature genes	Signature genes Name	Protein_function
NC_015947.1\|WP_014038751.1\|4162968_4163475_+\|Na+/H+-antiporter-subunit-E	unknown	unknown	gnl\|CDD\|181598
NC_015947.1\|WP_014038739.1\|4150239_4150827_-\|aminodeoxychorismate/anthranilate-synthase-component-II	unknown	unknown	gnl\|CDD\|235552
NC_015947.1\|WP_014038745.1\|4155780_4156110_-\|DnaJ-domain-containing-protein	unknown	unknown	gnl\|CDD\|236512
NC_015947.1\|WP_014038747.1\|4157397_4157883_+\|DUF962-domain-containing-protein	unknown	unknown	gnl\|CDD\|226914
NC_015947.1\|WP_014038752.1\|4163752_4164142_+\|Na+/H+-antiporter-subunit-G	unknown	unknown	gnl\|CDD\|237169
NC_015947.1\|WP_014038753.1\|4164230_4165196_-\|sodium:calcium-antiporter	unknown	unknown	gnl\|CDD\|223604
NC_015947.1\|WP_014038741.1\|4151676_4153152_-\|anthranilate-synthase-component-I	unknown	unknown	gnl\|CDD\|184146
NC_015947.1\|WP_014038738.1\|4149191_4150223_-\|anthranilate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234682
NC_015947.1\|WP_014038742.1\|4153349_4154303_-\|lipid-kinase-YegS	unknown	unknown	gnl\|CDD\|237281
NC_015947.1\|WP_014038740.1\|4150829_4151609_-\|DUF541-domain-containing-protein	unknown	unknown	gnl\|CDD\|377344
NC_015947.1\|WP_014038737.1\|4148322_4149117_-\|indole-3-glycerol-phosphate-synthase-TrpC	unknown	unknown	gnl\|CDD\|234710
NC_015947.1\|WP_014038744.1\|4155048_4155723_-\|ribulose-phosphate-3-epimerase	unknown	unknown	gnl\|CDD\|136958
NC_015947.1\|WP_014038755.1\|4166053_4166605_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378826
NC_015947.1\|WP_006399171.1\|4163471_4163756_+\|K+/H+-antiporter-subunit-F	unknown	unknown	gnl\|CDD\|180435
NC_015947.1\|WP_014038754.1\|4165271_4165928_-\|hypothetical-protein	unknown	unknown	unknown
NC_015947.1\|WP_014038743.1\|4154507_4154990_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NC_015947.1\|WP_014038748.1\|4158216_4161048_+\|monovalent-cation/H+-antiporter-subunit-A	unknown	unknown	gnl\|CDD\|237157
NC_015947.1\|WP_087944228.1\|4156248_4157181_+\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	unknown	unknown	gnl\|CDD\|237571
NC_015947.1\|WP_014038750.1\|4161436_4162972_+\|monovalent-cation/H+-antiporter-subunit-D	unknown	unknown	gnl\|CDD\|237166
NC_015947.1\|WP_014038749.1\|4161047_4161440_+\|Na+/H+-antiporter-subunit-C	unknown	unknown	gnl\|CDD\|236377

Protein	Function_ID	Function_description	E-value
NC_015947.1\|WP_014038751.1\|4162968_4163475_+\|Na+/H+-antiporter-subunit-E	gnl\|CDD\|181598	PRK08965, PRK08965, putative monovalent cation/H+ antiporter subunit E; Reviewed.	2.27879e-62
NC_015947.1\|WP_014038739.1\|4150239_4150827_-\|aminodeoxychorismate/anthranilate-synthase-component-II	gnl\|CDD\|235552	PRK05670, PRK05670, anthranilate synthase component II; Provisional.	4.55838e-132
NC_015947.1\|WP_014038745.1\|4155780_4156110_-\|DnaJ-domain-containing-protein	gnl\|CDD\|236512	PRK09430, djlA, co-chaperone DjlA.	1.53677e-18
NC_015947.1\|WP_014038747.1\|4157397_4157883_+\|DUF962-domain-containing-protein	gnl\|CDD\|226914	COG4539, COG4539, Predicted membrane protein [Function unknown].	1.07273e-15
NC_015947.1\|WP_014038752.1\|4163752_4164142_+\|Na+/H+-antiporter-subunit-G	gnl\|CDD\|237169	PRK12674, PRK12674, putative monovalent cation/H+ antiporter subunit G; Reviewed.	7.74884e-33
NC_015947.1\|WP_014038753.1\|4164230_4165196_-\|sodium:calcium-antiporter	gnl\|CDD\|223604	COG0530, ECM27, Ca2+/Na+ antiporter [Inorganic ion transport and metabolism].	4.36171e-44
NC_015947.1\|WP_014038741.1\|4151676_4153152_-\|anthranilate-synthase-component-I	gnl\|CDD\|184146	PRK13565, PRK13565, anthranilate synthase component I; Provisional.	0
NC_015947.1\|WP_014038738.1\|4149191_4150223_-\|anthranilate-phosphoribosyltransferase	gnl\|CDD\|234682	PRK00188, trpD, anthranilate phosphoribosyltransferase; Provisional.	0
NC_015947.1\|WP_014038742.1\|4153349_4154303_-\|lipid-kinase-YegS	gnl\|CDD\|237281	PRK13054, PRK13054, lipid kinase; Reviewed.	1.27755e-159
NC_015947.1\|WP_014038740.1\|4150829_4151609_-\|DUF541-domain-containing-protein	gnl\|CDD\|377344	pfam04402, SIMPL, Protein of unknown function (DUF541). Members of this family have so far been found in bacteria and mouse SwissProt or TrEMBL entries. However possible family members have also been identified in translated rat (Genbank:AW144450) and human (Genbank:AI478629) ESTs. A mouse family member has been named SIMPL (signalling molecule that associates with mouse pelle-like kinase). SIMPL appears to facilitate and/or regulate complex formation between IRAK/mPLK (IL-1 receptor-associated kinase) and IKK (inhibitor of kappa-B kinase) containing complexes, and thus regulate NF-kappa-B activity. Separate experiments demonstrate that a mouse family member (named LaXp180) binds the Listeria monocytogenes surface protein ActA, which is a virulence factor that induces actin polymerization. It may also bind stathmin, a protein involved in signal transduction and in the regulation of microtubule dynamics. In bacteria its function is unknown, but it is thought to be located in the periplasm or outer membrane.	1.43348e-20
NC_015947.1\|WP_014038737.1\|4148322_4149117_-\|indole-3-glycerol-phosphate-synthase-TrpC	gnl\|CDD\|234710	PRK00278, trpC, indole-3-glycerol phosphate synthase TrpC.	1.34155e-153
NC_015947.1\|WP_014038744.1\|4155048_4155723_-\|ribulose-phosphate-3-epimerase	gnl\|CDD\|136958	PRK08745, PRK08745, ribulose-phosphate 3-epimerase; Provisional.	1.85077e-152
NC_015947.1\|WP_014038755.1\|4166053_4166605_+\|hypothetical-protein	gnl\|CDD\|378826	pfam12200, DUF3597, Domain of unknown function (DUF3597). This family of proteins is found in bacteria, eukaryotes and viruses. Proteins in this family are typically between 126 and 281 amino acids in length. The function of this domain is unknown. The structure of this domain has been found to contain five helices with a long flexible loop between helices one and two.	3.38262e-06
NC_015947.1\|WP_006399171.1\|4163471_4163756_+\|K+/H+-antiporter-subunit-F	gnl\|CDD\|180435	PRK06161, PRK06161, putative monovalent cation/H+ antiporter subunit F; Reviewed.	9.48908e-36
NC_015947.1\|WP_014038743.1\|4154507_4154990_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	7.30299e-14
NC_015947.1\|WP_014038748.1\|4158216_4161048_+\|monovalent-cation/H+-antiporter-subunit-A	gnl\|CDD\|237157	PRK12648, PRK12648, putative monovalent cation/H+ antiporter subunit A; Reviewed.	0
NC_015947.1\|WP_087944228.1\|4156248_4157181_+\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	gnl\|CDD\|237571	PRK13961, PRK13961, phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional.	0
NC_015947.1\|WP_014038750.1\|4161436_4162972_+\|monovalent-cation/H+-antiporter-subunit-D	gnl\|CDD\|237166	PRK12666, PRK12666, putative monovalent cation/H+ antiporter subunit D; Reviewed.	0
NC_015947.1\|WP_014038749.1\|4161047_4161440_+\|Na+/H+-antiporter-subunit-C	gnl\|CDD\|236377	PRK09094, PRK09094, putative monovalent cation/H+ antiporter subunit C; Reviewed.	2.6717e-63

>NC_015947.1|WP_087944228.1|4156248_4157181_+|phosphoribosylaminoimidazolesuccinocarboxamide-synthase
MPVPTTLLQSDLPGLPLRHRGKVRDVFDIPRERLPAGTPPGEYLLMVATDRLSAFDVVLPDPIPGKGEMLCQVSNFWFAKTAHLMPNHLTGIDVASVLPEGVDPALYAKRAVVTRKLKPVPVEAIARGYLIGSGWKDYQRTGKVSGIDLPDGLRQAEQLPEPIFTPSTKAAVGDHDENIDFDAMVKQVGADLAERVRDATLRIYKFAADYARERGIILADTKFEFGTDADGRLYIMDEMLTPDSSRYWPADEYEVGTSPPSYDKQFVRDYLETLDWGKTAPGPSIPAEIIERTRAKYAEALQRLAGISVD
>NC_015947.1|WP_014038745.1|4155780_4156110_-|DnaJ-domain-containing-protein
MRWYGKLLGFIAGALLFRPNPLFGAVVGLLIGHAFDSDWFRLNKENPYRELGLTSEATDAEVERAYRRLISQYHPDKLGGAAPELQQQAEQKSRRINAAYDRIKTLRKR
>NC_015947.1|WP_014038744.1|4155048_4155723_-|ribulose-phosphate-3-epimerase
MSNCLIAPSILSANFARLGEEVDNVLAAGADWVHFDVMDNHYVPNLTIGPMVCQALRKHGVTAPIDVHLMVEPVDRIIPDFAEAGATYISFHPEASRHVHRTIQLIRSLGCKPGIVLNPATPVDILDWVLDDLDLVLLMSVNPGFGGQAFIPSALDKLKVVRKMIDASGKDIRLEIDGGVKADNIGEIAAAGADTFVAGSAIFNAKTSYQDVIAQMRANVAAAR
>NC_015947.1|WP_014038743.1|4154507_4154990_-|GNAT-family-N-acetyltransferase
MALLNIRPATVADAGLILHFIRELAIYEKAEHSVQTDEIGIAESLFGADATARALICEADGEAIGYAVYFYNYSTWLGRKGIYLEDLYVSQEKRGVGAGKALLKYIARQAVAEGCGRFEWSVLDWNTPAIEFYTAAGAAPQDEWTVYRLQGQALHDFANG
>NC_015947.1|WP_014038742.1|4153349_4154303_-|lipid-kinase-YegS
MTAPRWRLILNGKSAGNEELREAVGHWRGQGVQLDVRVTWEDGDAERYVAEAIDHGVDVIVAAGGDGTLSAVAETLAHREEAADALPSLALIPMGTANDFATAAGIPTEPKAAFALIGKAMPHAIDLLRVDADGTPWWCANLASGGFGTQVTVETDAGLKKMLGGLAYVITGIAKLGRIEPIQARLSGPDFAWEGDFIALGIGNGRQAGGGQQLCPQALIDDGLLDVTVLPELEGEVTATLGQMLKSGTQAALEQLATRARLPWLQVESERPLTLNLDGEPVQARQFRIACVPGRVRMHLPASCPLLGGGSAANAPA
>NC_015947.1|WP_014038741.1|4151676_4153152_-|anthranilate-synthase-component-I
MNSHAQFQLQAAEGHTHIPVVREVLSDLDTPLSVYLKLADGPNTYLFESVEGGERFGRYSIIGLPARRVYAFHGHTLTVREDGQVVDTRVVADPFAEVEALRSAHSVPKLEGLPGFTGGLVGWFGFECIGYIEPRLAPPAGRDELGTPDILLLDSNELAVFDNLKGRLYLIVHADPRVEGAFEQAQARLDALTAKLRAPGAGYPAPLNSDVLDESDFVSGFTREGFVDAVQRSKEYIRAGDIFQVVLSQRLSVPFKARPVDVYRALRALNPSPYMYFLDVGDLQVVGSSPEILVRLQDGEVTVRPIAGTRPRGATVEQDLALEAELLADPKERAEHLMLIDLGRNDAGRVSKAGTVEVGEQFVIERYSHVMHIVSEVTGQLQPGLSYADVLRATFPAGTVSGAPKIRALEVIRELEPIKRNVYAGSIGYIGWHGDADTAIAIRTAVIKDGRLYVQAGAGIVYDSDPDKEWDETMNKGRALFRAVAQAAKGL
>NC_015947.1|WP_014038740.1|4150829_4151609_-|DUF541-domain-containing-protein
MKLLSALLWSSLLATMAPSAWAQANTIPSQPHLLVKGEARREVMPDRFGLQLNIEETDMDADAARRRVQDNVARALALFKQNKAVEGSVRAENLRIGPATRYEQNRQVFIGTRVSRQLRASFASVKAMQDVLGALKANENVQVSSVAPTYSGEVALRRELKGEAAAKTRESAQGLAKAYGTQLRGLYSISDVAPNFAYGIQAGSWPSSGDLVTPPSPPSPAAQMDMIETTGSRLRESIEAGPITYTENVYAIFLISDGT
>NC_015947.1|WP_014038739.1|4150239_4150827_-|aminodeoxychorismate/anthranilate-synthase-component-II
MLWMIDNYDSFTYNLVQYLQTLGAEVKVVRNDAMSVDEIAAQKPERIVISPGPCTPNEAGVSLELIQRLGPTTPILGVCLGHQGIGQVYGGTVIRAGNIMHGKTSPIRHEGKGVFAGLPDRYQATRYHSLVVDKNSLPDVLEVTAWTENDDGSIEEIMGLRHRQFPVEGVQFHPESILTEHGHALLRNFLQRPAA
>NC_015947.1|WP_014038738.1|4149191_4150223_-|anthranilate-phosphoribosyltransferase
MSFSPQEALQRTIEHREIFFDEMVDLMRQIMRGDVSPMMTAAILTGLRVKKETIDEIAAAATVMREFALAVPVADSTHLVDIVGTGGDGSHTFNISTCAMFVAAAAGARVAKHGNRSVSSKSGSADAVEALGAAIELQPAQVAAAIEQTGIGFMFAPIHHPSMKVVAPVRREMGVRTIFNILGPLTNPASAPSVLMGVFHPDLVGIQARVLRELGTERAMVVWGRDNMDEISLGAGTLVGELRDGKVREYEIHPEDFGIAMSASRNLRVDSPEQSIAMLRAVLDNEPGPALDIVALNAGAALYVAGVASDIGDGLARARAAIANGSARQRLQQYVETTRALVA
>NC_015947.1|WP_014038737.1|4148322_4149117_-|indole-3-glycerol-phosphate-synthase-TrpC
MSDILQTILARKAEEVAQRRAQRPLEELQAALASAPPVRGFVRALQAAVANGDPAVIAEVKKASPSKGVIRPDFRPADIAVSYEFGGASCLSVLTDVDFFQGADAYLQQAREACTLPVLRKDFVIDAYQVYEARVLGADCILLIVAALDDTQLATLSELALSLGMDVLVEVHDIDELERALQVPAPMIGINNRNLRTFEVSLQTTLDMQNAVPRDRLLVTESGILGPQDVALMRDAGIHAFLVGEAFMRVEEPGEGLRQLFFAA
>NC_015947.1|WP_014038747.1|4157397_4157883_+|DUF962-domain-containing-protein
MQTSTELARPIDRYFASYSDDHRNVINQRIHVVAVPAILWSVVALLWCLPPLITWFQYGIWSAFAMFSAWCFYNKLSRPLGIGMLIQFFVFGCLCRLLEAEIGIQALRWLAVGVFVVAWIAQFIGHKFEGRKPSFLTDLTYLLIGPAWVMAKFYRKLDWRY
>NC_015947.1|WP_014038748.1|4158216_4161048_+|monovalent-cation/H+-antiporter-subunit-A
MLPSLPLLLALPFLMAAAVAAFPRSSRSTAAWLAALAPLGGLAILGWLTPSVLDGQVVRTLVPWLPQIGLDFTLRLDGLAWMFAGLVLGIGALVVLYARYYLSQQDNAHRFYCYLLLFMGAMLGMVLSGNLLLLMIFWEMTSISSFLLIGFWSHRQDAREGARMALVITGGGGLALLGGVLLIGRIVGSFDLDVVLAAGEQIRASALYPYALFLVLAGIFTKSAQFPFHFWLPHAMAAPTPVSAYLHSATMVKAGVFLLARLHPALAGSDLFFYTVSGIGALTLLIGAWNAIFQHDLKGLLAYSTISHLGLITLLFGLSTPMAVVAGVFHILNHATFKASLFMAAGIIDHETGTRDMRRLGGLRRLMPFTSALAIIASLAMAGIPLLNGFLSKEMLFAEALTAGGGPGAMRTAVSIAALLAGVFGVAYSLRFVHDTFFGPGPHDLDRVPHEPPRWMKVPVELLVVICIAVGVAPALTVAPVLHAAAASILGNAMPEYSLAVWHGFNLPLAMSAIGVVGGVALYFGLRKLINLHGVETRTTGRNVFHAQLDAISALAMRLTNGIANGSLQRMLLGLVLVAIVVAAAPFVANPASPNWTAPQPIPLLGWALWLVMMACAVATLRVYKQRLLAVLLVGGVGLMVALTFVFLSAPDLALTQLLVEMVTLVLMLLGMNYLPAQSGPERPRWRKRRDAVIAIIAGAGLGALAYSAMTLPPNTMAGELLGRALPEAYGQNVVNVILVDFRGFDTFGEITVFGIAALVVHALLRRTRMAPEQIMPGPPIKLPVPADLAQIMFPLTLTVSIFLFLRGHNAPGGGFIAGLVLAVPLLIQYVIQGTASVESRFGFDYIRCIGMGLLIAILSGSASMLFGVPFLTSGHLDLYLPLIGDVPLASAIGFDIGVYLVVFGGAMLMLSMMATVKPSRTRTARKGEIDLQRRSARTGEMH
>NC_015947.1|WP_014038749.1|4161047_4161440_+|Na+/H+-antiporter-subunit-C
MELALASAIGVLTAIGVYLLLRARSFDVILGMTFLSYATNLLIFAGGRVVLGKAPVLQEGVDSHLGNYTDPLPQALVLTAIVIAFAMTAVSIVLAMRSRSDNHSDHVDAHEPDDDLQDEGVPPRQGEDRA
>NC_015947.1|WP_014038750.1|4161436_4162972_+|monovalent-cation/H+-antiporter-subunit-D
MNHLVILPILIPLLGAALSLFVEHRRYGHRVQRAVAWTSLSALALAVGLLFATTASGDINVYLLGDWPSRLGIALVADRLSAWMLLTTLLLAIPCLLHACSGWDRRAPHFHALFQFQLVGLNGAFLTGDIFNLFVFFEVMLIASYGLLLSGGRGLRMRIGLHYVVFNVTASTLFLIALGLLYASLGSLNMAELSQRIAEVPPAQLTLVKATMGLLLLVFCAKAALMPLYLWLPEAYSRAPAAVAALFAIMTKVGLYSVLRIQMLWFGDDAGAMAGYGRDWLLWAGVATLVLGGLGALAATRLRVLISYLVIVSAATLFIAFSVGTPKVLSAGLYYLPHSSFVAAALFLIADLIRRRRGGASDRKEVVAPMPGKETPAVLFLIGAVSVAGLPPLSGFLAKAALLAGMPAQYTGPVWTAVLVSSLLVIMGLTRGGIRLFWRVPPVEADAPKPRKARLRRVELYAACILLAYGIGMTLAAAPLMRYTDATAAQLLQPSEYVQQLRATAPEIRQP
>NC_015947.1|WP_014038751.1|4162968_4163475_+|Na+/H+-antiporter-subunit-E
MTAQRSLFRRLIPSPMLSIMVVAFWLLMSDSFTLGQIVLGLLLGVVVPLFAARLDREFARIGTLRPLPKLLCVTLWDILMSNIRVAIQVLGPEKNIHPGFIWLPLDIANIHGIAALTSMITLTPGTVSAALSDDRKFLLVHVLHLEDPQDLIDTIKRRYEAPLMEIFP
>NC_015947.1|WP_006399171.1|4163471_4163756_+|K+/H+-antiporter-subunit-F
MTGFQIIQTTLVVCMHVVGLAMLLATWRLLRGPTVPDRILALDTLSVTAIAELMLFGMYLNSAIYFEAALVIAMLGFGSTVVLSKFVLRRDIVE
>NC_015947.1|WP_014038752.1|4163752_4164142_+|Na+/H+-antiporter-subunit-G
MITAIQIGLSILLLFGCFFILVGALGLVKLSTFFKRLHAPTKASTLGVGCVLVCSVCYHIFLGQDPQPRELLITVFLFITAPISAHMMAKAALSLLMETRPSLPGNEPAAEEQLPPPEPVREKEHAQNR
>NC_015947.1|WP_014038753.1|4164230_4165196_-|sodium:calcium-antiporter
MIAIAIAWFLLGLLLLALGGDSIVKAVSGLAQRFGASPFTAGLLLLGVTTSLPELAVNARALAVGQPELALGNAVGSSIVNLGLTLAVAAIAAPLLLRARLQTVLWWSLLAAGVLLILFGLDGRLARWEGGVLVAGFIVVQVLLLRRGRVESAEVQAAIAESALSRTSLPLNVLRVLIAALTLYWGARLVVGAAADFGAALGWTPLLVGLLPVAIGTALPEVATAIAAARRGHGDMVLGHVLGSSVVNLLLVIGAMAMLQPLALPASFVRLELPALLAFALVLYPMLRGDLKISRSEGGILLVAFVGWFVLELLLVGAPAL
>NC_015947.1|WP_014038754.1|4165271_4165928_-|hypothetical-protein
MKHLPLAGLLLLSLAACNGGSDKQGVAGSGSDTPAETASATGPAQSADPDLAARPANDLRADSPARLDGFAGAKLGANIAEVRSGFGAPLQGLGTDAAGKPLPADDNSDECYYLHPQGAEDPRLMIEGRKLVRYEVTSTAIVAPGGGKVGMTLGELQLLYPERADVGPDKYDDQAQHLRVRPAQDGAAIIDFSLSRDGKVDGWRVGQTPQVDYVEGCL
>NC_015947.1|WP_014038755.1|4166053_4166605_+|hypothetical-protein
MQPRKTDLARTALQAHRAPLDMRQRRLLILCDGQRSIADLTGLLGQDAPAMVIQLVQAGYLSTGTAAAAAPPPSPAPAAAPVPPAPPAAAPAATPATAVERRRSLVAARIYVLGILEMQRHPQAAALFRDLQQARAESEVLQVLHSAMQMLPGLTSEGYCQRVRQRLLEALPLEHCDAFAEAA

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

259165 : 270324

Siphoviridae_environmental_samples(37.5%)

head,tail

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014035623.1\|259165_259678_+\|head,tail	phage gp6-like head-tail connector protein	NA	NA	NA	NA
WP_014035624.1\|259674_260025_+\|head,tail	head-tail adaptor protein	NA	NA	NA	NA
WP_014035625.1\|260048_260405_+	DUF3168 domain-containing protein	NA	NA	NA	NA
WP_014035626.1\|260479_261139_+\|tail	tail protein	C4ML12	Xanthomonas_virus	1.8e-64	58.0
WP_014035627.1\|261138_261447_+	hypothetical protein	NA	NA	NA	NA
WP_014035628.1\|261497_261755_+	DUF1799 domain-containing protein	A0A2H4JBP7	uncultured_Caudovirales_phage	1.6e-05	32.9
WP_101764749.1\|261866_263189_+\|tail	phage tail protein	K7PM62	Enterobacteria_phage	6.4e-21	32.0
WP_014035630.1\|263188_263518_+\|tail	phage tail protein	C7BGC9	Burkholderia_phage	1.6e-21	52.7
WP_014035631.1\|263529_264747_+	hypothetical protein	NA	NA	NA	NA
WP_014035632.1\|264743_265439_+\|tail	phage minor tail protein L	A0A2R3UA90	Siphoviridae_environmental_samples	1.6e-92	67.1
WP_014035633.1\|265503_266244_+	C40 family peptidase	A0A2R3UAR4	Siphoviridae_environmental_samples	1.5e-80	58.0
WP_014035634.1\|266236_266839_+\|tail	tail assembly protein	W0LI27	Edwardsiella_phage	5.7e-49	52.5
WP_014035635.1\|266835_270324_+	host specificity protein J	A0A2R3UA88	Siphoviridae_environmental_samples	0.0e+00	58.5

DBSCAN-SWA_2

588921 : 595162

Enterobacteria_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014035898.1\|588921_589977_+	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	4.6e-78	45.9
WP_014035899.1\|589991_590879_+	glucose-1-phosphate thymidylyltransferase RfbA	I7I009	Enterobacteria_phage	6.3e-97	58.2
WP_014035900.1\|590875_591433_+	dTDP-4-dehydrorhamnose 3,5-epimerase	I7HJC4	Enterobacteria_phage	7.8e-45	50.6
WP_014035901.1\|591429_592323_+	dTDP-4-dehydrorhamnose reductase	A0A291LA50	Escherichia_phage	2.1e-28	38.6
WP_014035902.1\|592398_593802_-	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase	A0A1V0SH58	Hokovirus	5.0e-48	29.5
WP_014035903.1\|593815_595162_-	phosphomannomutase/phosphoglucomutase	A0A127AWJ1	Bacillus_phage	2.9e-29	26.5

DBSCAN-SWA_3

3176083 : 3188631

Xanthomonas_virus(66.67%)

tail

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014037985.1\|3176083_3184360_-\|tail	phage tail protein	I7HDJ4	Xanthomonas_virus	4.9e-10	47.8
WP_014037986.1\|3184350_3184746_-	hypothetical protein	Q2NPH1	Xanthomonas_virus	1.8e-27	48.1
WP_014037987.1\|3184745_3185207_-	DUF1833 domain-containing protein	I7GYA2	Xanthomonas_virus	8.5e-37	50.3
WP_014037988.1\|3185203_3185557_-	hypothetical protein	I7H418	Xanthomonas_virus	4.8e-16	39.0
WP_042359267.1\|3185553_3187719_-\|tail	phage tail tape measure protein	A0A2R3UAA7	Siphoviridae_environmental_samples	2.5e-38	33.7
WP_014037990.1\|3187963_3188182_-	hypothetical protein	NA	NA	NA	NA
WP_014037991.1\|3188286_3188631_-	hypothetical protein	G9FHI3	Rhodococcus_phage	7.5e-22	50.0

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_015947

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection