CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_016025	Chloracidobacterium thermophilum B chromosome 2, complete sequence	4 crisprs	c2c9_V-U4,Cas14c_CAS-V-F,csa3,cas3,cas8u1,cas7,csb2gr5,WYL,cas6,cas8b3,cas5,cas1,cas2,Cas9_archaeal,PD-DExK,Cas14u_CAS-V	0	9	0	0
NC_016024	Chloracidobacterium thermophilum B chromosome 1, complete sequence	5 crisprs	cmr3gr5,cmr4gr7,cmr5gr11,csm3gr7,csm6,cas3,cas8u1,csb1gr7,csb2gr5,cmr6gr7,cas10,cmr1gr7,c2c9_V-U4,DinG,Cas14u_CAS-V,DEDDh,csa3,PD-DExK	2	0	2	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_016025_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016025_1

170569-170669

Unclear

Consensus_repeat	Method
GTAGGGGCGGGTTCCGAACCCGCCC	CRISPRCasFinder

1 spacers

cas3,cas8u1,cas7,csb2gr5

The CRISPR arrays of NC_016025_1

>merge|NC_016025|1|170569-170669|CRISPRCasFinder
GTAGGGGCGGGTTCCGAACCCGCCCCGGAACCACCCGGCATCCAGCGTTTCGCACCCTCGGGAGTAGCGAGTGGTAGTACGGGCGGGTTCCGAACCCGCCC

>NC_016025|1|1|170569-170669|CRISPRCasFinder
GTAGGGGCGGGTTCCGAACCCGCCC	CGGAACCACCCGGCATCCAGCGTTTCGCACCCTCGGGAGTAGCGAGTGGTA
GTACGGGCGGGTTCCGAACCCGCCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_016025.1\|WP_014100875.1\|160330_160720_+\|type-II-toxin-antitoxin-system-VapC-family-toxin	unknown	unknown	gnl\|CDD\|350220
NC_016025.1\|WP_041570090.1\|171515_172868_-\|oxygen-independent-coproporphyrinogen-III-oxidase	unknown	unknown	gnl\|CDD\|236430
NC_016025.1\|WP_014100886.1\|172830_174486_-\|magnesium-protoporphyrin-IX-monomethyl-ester-anaerobic-oxidative-cyclase	unknown	unknown	gnl\|CDD\|131081
NC_016025.1\|WP_014100890.1\|181280_182837_+\|type-I-U-CRISPR-associated-protein-Cas5/Cas6	csb2gr5	cls000315_csb2gr5_CAS-I-U	gnl\|CDD\|274005
NC_016025.1\|WP_014100889.1\|179919_181284_+\|type-I-U-CRISPR-associated-protein-Cas7	cas7	cd09678_cas7_CAS-I-U	gnl\|CDD\|378223
NC_016025.1\|WP_014100874.1\|160100_160331_+\|antitoxin	unknown	unknown	gnl\|CDD\|226603
NC_016025.1\|WP_148264086.1\|174524_174767_+\|hypothetical-protein	unknown	unknown	unknown
NC_016025.1\|WP_014100884.1\|171146_171296_+\|type-II-toxin-antitoxin-system-VapC-family-toxin	unknown	unknown	gnl\|CDD\|350220
NC_016025.1\|WP_014100888.1\|177787_179923_+\|type-I-U-CRISPR-associated-protein-Csx17	cas8u1	cd09767_cas8u1_CAS-I-U	gnl\|CDD\|274989
NC_016025.1\|WP_014100887.1\|174995_177788_+\|DEAD/DEAH-box-helicase	cas3	cd09696_cas3_CAS-I-U	gnl\|CDD\|274235
NC_016025.1\|WP_014100882.1\|170024_170420_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|315987
NC_016025.1\|WP_014100873.1\|158366_159695_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|315987
NC_016025.1\|WP_014100878.1\|164283_165858_-\|tetratricopeptide-repeat-containing-protein	unknown	unknown	gnl\|CDD\|315987
NC_016025.1\|WP_041569950.1\|183254_183488_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|153084
NC_016025.1\|WP_014100880.1\|166506_166896_+\|type-II-toxin-antitoxin-system-VapC-family-toxin	unknown	unknown	gnl\|CDD\|350220
NC_016025.1\|WP_014100881.1\|167200_169957_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|274350
NC_016025.1\|WP_014100883.1\|170904_171150_+\|DUF2281-domain-containing-protein	unknown	unknown	gnl\|CDD\|378366
NC_016025.1\|WP_014100876.1\|161008_161707_-\|tetratricopeptide-repeat-containing-protein	unknown	unknown	gnl\|CDD\|315987
NC_016025.1\|WP_148264083.1\|161898_163857_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|274350
NC_016025.1\|WP_014100879.1\|166264_166510_+\|DUF2281-domain-containing-protein	unknown	unknown	gnl\|CDD\|378366

Protein	Function_ID	Function_description	E-value
NC_016025.1\|WP_014100875.1\|160330_160720_+\|type-II-toxin-antitoxin-system-VapC-family-toxin	gnl\|CDD\|350220	cd09872, PIN_Sll0205-like, VapC-like PIN domain of Sll0205 protein and homologs. Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of the Synechocystis sp. (strain PCC 6803) Sll0205 protein and other uncharacterized homologs are included in this subfamily. They are similar to the PIN domains of the Mycobacterium tuberculosis VapC and Neisseria gonorrhoeae FitB toxins of the prokaryotic toxin/antitoxin operons, VapBC and FitAB, respectively, which are believed to be involved in growth inhibition by regulating translation. These toxins are nearly always co-expressed with an antitoxin, a cognate protein inhibitor, forming an inert protein complex. Disassociation of the protein complex activates the ribonuclease activity of the toxin by an, as yet undefined mechanism. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	1.58273e-49
NC_016025.1\|WP_041570090.1\|171515_172868_-\|oxygen-independent-coproporphyrinogen-III-oxidase	gnl\|CDD\|236430	PRK09249, PRK09249, coproporphyrinogen dehydrogenase.	0
NC_016025.1\|WP_014100886.1\|172830_174486_-\|magnesium-protoporphyrin-IX-monomethyl-ester-anaerobic-oxidative-cyclase	gnl\|CDD\|131081	TIGR02026, BchE, magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase. This model represents the cobalamin-dependent oxidative cyclase, a radical SAM enzyme responsible for forming the distinctive E-ring of the chlorin ring system under anaerobic conditions. This step is essential in the biosynthesis of both bacteriochlorophyll and chlorophyll under anaerobic conditions (a separate enzyme, AcsF, acts under aerobic conditions). This model identifies two clades of sequences, one from photosynthetic, non-cyanobacterial bacteria and another including Synechocystis and several non-photosynthetic bacteria. The function of the Synechocystis gene is supported by gene clustering with other photosynthetic genes, so the purpose of the gene in the non-photosynthetic bacteria is uncertain. Note that homologs of this gene are not found in plants which rely solely on the aerobic cyclase.	0
NC_016025.1\|WP_014100890.1\|181280_182837_+\|type-I-U-CRISPR-associated-protein-Cas5/Cas6	gnl\|CDD\|274005	TIGR02165, CRISPR-associated_protein_GSU0054_family, CRISPR-associated protein GSU0054/csb2, Dpsyc system. This model represents a CRISPR-associated protein from the Dpsyc subtype (a type I-C variant), named for Desulfotalea psychrophila LSv54. CRISPR systems confer resistance in prokaryotes to invasive DNA or RNA, including phage and plasmids. CRISPR-associated proteins typically are found near CRISPR repeats and other CRISPR-associated proteins, have low levels of sequence identify, have sequence relationships that suggest lateral transfer, and show some sequence similarity to DNA-active proteins such as helicases and repair proteins.	5.17339e-19
NC_016025.1\|WP_014100889.1\|179919_181284_+\|type-I-U-CRISPR-associated-protein-Cas7	gnl\|CDD\|378223	pfam09617, Cas_GSU0053, CRISPR-associated protein GSU0053 (Cas_GSU0053). This entry is found in CRISPR-associated (cas) proteins in the genomes of Geobacter sulfurreducens PCA and Desulfotalea psychrophila LSv54 (both Desulfobacterales from the Deltaproteobacteria), Gemmata obscuriglobus (a Planctomycete), and Actinomyces naeslundii MG1 (Actinobacteria).	4.44668e-30
NC_016025.1\|WP_014100874.1\|160100_160331_+\|antitoxin	gnl\|CDD\|226603	COG4118, Phd, Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning].	1.25157e-10
NC_016025.1\|WP_014100888.1\|177787_179923_+\|type-I-U-CRISPR-associated-protein-Csx17	gnl\|CDD\|274989	TIGR04113, hypothetical_protein_AaLAA1DRAFT_1703, CRISPR-associated protein Csx17, subtype Dpsyc. Members of this protein family are found exclusively in CRISPR-associated (cas) type I system gene clusters of the Dpsyc subtype. Markers for that type include a variant form of cas3 (model TIGR02621) and the GSU0054-like protein family (model TIGR02165). This family occurs in less than half of known Dpsyc clusters.	1.86641e-42
NC_016025.1\|WP_014100884.1\|171146_171296_+\|type-II-toxin-antitoxin-system-VapC-family-toxin	gnl\|CDD\|350220	cd09872, PIN_Sll0205-like, VapC-like PIN domain of Sll0205 protein and homologs. Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of the Synechocystis sp. (strain PCC 6803) Sll0205 protein and other uncharacterized homologs are included in this subfamily. They are similar to the PIN domains of the Mycobacterium tuberculosis VapC and Neisseria gonorrhoeae FitB toxins of the prokaryotic toxin/antitoxin operons, VapBC and FitAB, respectively, which are believed to be involved in growth inhibition by regulating translation. These toxins are nearly always co-expressed with an antitoxin, a cognate protein inhibitor, forming an inert protein complex. Disassociation of the protein complex activates the ribonuclease activity of the toxin by an, as yet undefined mechanism. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	1.85538e-22
NC_016025.1\|WP_014100887.1\|174995_177788_+\|DEAD/DEAH-box-helicase	gnl\|CDD\|274235	TIGR02621, CRISPR-associated_helicase_Cas3, CRISPR-associated helicase Cas3, subtype Dpsyc. This model describes a CRISPR-associated putative DEAH-box helicase, or Cas3, of a subtype found in Actinomyces naeslundii MG1, Geobacter sulfurreducens PCA, Gemmata obscuriglobus UQM 2246, and Desulfotalea psychrophila. This protein includes both DEAH and HD motifs.	1.9982e-55
NC_016025.1\|WP_014100882.1\|170024_170420_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|315987	pfam13424, TPR_12, Tetratricopeptide repeat.	1.0292e-12
NC_016025.1\|WP_014100873.1\|158366_159695_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|315987	pfam13424, TPR_12, Tetratricopeptide repeat.	4.30122e-14
NC_016025.1\|WP_014100878.1\|164283_165858_-\|tetratricopeptide-repeat-containing-protein	gnl\|CDD\|315987	pfam13424, TPR_12, Tetratricopeptide repeat.	1.05271e-15
NC_016025.1\|WP_041569950.1\|183254_183488_+\|hypothetical-protein	gnl\|CDD\|153084	cd01675, RNR_III, Class III ribonucleotide reductase. Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in strict or facultative anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). The class III enzyme from phage T4 consists of two subunits, this model covers the larger subunit which contains the active and allosteric sites.	0.000670056
NC_016025.1\|WP_014100880.1\|166506_166896_+\|type-II-toxin-antitoxin-system-VapC-family-toxin	gnl\|CDD\|350220	cd09872, PIN_Sll0205-like, VapC-like PIN domain of Sll0205 protein and homologs. Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of the Synechocystis sp. (strain PCC 6803) Sll0205 protein and other uncharacterized homologs are included in this subfamily. They are similar to the PIN domains of the Mycobacterium tuberculosis VapC and Neisseria gonorrhoeae FitB toxins of the prokaryotic toxin/antitoxin operons, VapBC and FitAB, respectively, which are believed to be involved in growth inhibition by regulating translation. These toxins are nearly always co-expressed with an antitoxin, a cognate protein inhibitor, forming an inert protein complex. Disassociation of the protein complex activates the ribonuclease activity of the toxin by an, as yet undefined mechanism. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	7.55203e-57
NC_016025.1\|WP_014100881.1\|167200_169957_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	5.39664e-31
NC_016025.1\|WP_014100883.1\|170904_171150_+\|DUF2281-domain-containing-protein	gnl\|CDD\|378366	pfam10047, DUF2281, Protein of unknown function (DUF2281). Members of this family of hypothetical bacterial proteins have no known function.	2.75833e-05
NC_016025.1\|WP_014100876.1\|161008_161707_-\|tetratricopeptide-repeat-containing-protein	gnl\|CDD\|315987	pfam13424, TPR_12, Tetratricopeptide repeat.	2.52609e-16
NC_016025.1\|WP_148264083.1\|161898_163857_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	1.45229e-27
NC_016025.1\|WP_014100879.1\|166264_166510_+\|DUF2281-domain-containing-protein	gnl\|CDD\|378366	pfam10047, DUF2281, Protein of unknown function (DUF2281). Members of this family of hypothetical bacterial proteins have no known function.	1.4833e-05

>NC_016025.1|WP_014100882.1|170024_170420_-|tetratricopeptide-repeat-protein
MIKRIQVMALAAVLCLTGAMAYAQGAGGEWETLSREVMELYRAGKYDQALVVAKKALEVAEKSVGPEHPNVAKSLNNLAYLYNAQGQYAQAEPLFRRALAIQEKALGPDHPDVATNLNNLAVLYKNQGQYA
>NC_016025.1|WP_014100881.1|167200_169957_-|tetratricopeptide-repeat-protein
MAQSLNNLADLYQAQGQYAQAEPLYRRALTIREKALGPDHSDVATNLNNLALLYDAQGQYAQAEPLYKRALTIREKALGTDHPDVATSLNNLAGIYQNQGQHAQAEPLHRRALFIREKVLGTDHPDVATSLNNLATLYCDQGLYAQAEPLFKRALVITEKALGADHPDVAQSLNNLAMIYANQGRYDQAEPLHKRALSIQEKVLGPDHPDVATSLSNLAALYHAQGQYAQAEPLLKRSLAIMEKALGPDHPDVATSLNNLAALYYVQGQYTQAEPLFKRTLATMEKTLGSDHPDVATILSNLAGIYIDQGQHARAEPLYRRTLAIREKALGPDHPDVATSLSCLALLYAKQGQYTQAEPLYRRALAIMEKALGPDHPVVAMSLNNLAGLYRAQGQYAQAELLYKRSLVIREQALGPDHPDVAASLNNLAAVYRDQGQYAQAEPLHRRALAILEKALGPDHPDVAASLSSLAGLYRAQGQYAQAEPIYKRALAIREKALGSDHPDVAESLNNLALFYTKQGQYTQAEPLHRRALAILEKALGPDHPDVAASLHNLAGFYQAQGQYAQAEPLYRRTLAIREKTLGPDHPDVATNLSNLAEIYRGQSRYAQAEPLYRRALAIWEKALGPDHPNVAASLNNLADLYREQGQYAQAEPLFKRALAIQEKTLGTDHPDVALSLNNLALLYADQGQYTQAEPLYKRTLAIWEKALGPDHPAVATVLHNLAGIYQDQGQYAQAETLYRRALTVKEKSLGSDHPNVATSLNNLAMLYAKQGQYAQAESLFRRSLTIREKALGPDHPDVAASLHNLAGIYQDQEQYATAEPLFRRALAIREKALGSDHPAVAQSLHNLARLYYAQGQYAQAEPLYRRSLVIREKALGPNHPDVATSLRNLALLYRATQRITEAEQLEERAAKIKANDK
>NC_016025.1|WP_014100880.1|166506_166896_+|type-II-toxin-antitoxin-system-VapC-family-toxin
MKLLLDTHTVLWFWWDDPQLGATAKAAICNPANQKFVSLVSPWEVAIKVSLKKLDIGGSYAGFFRQHMLRTYFEWLPFRDDHFNCLTTLPFHHRDPFDRMLVAQSLIEGMPLLSADTIFDTYGVNRIWD
>NC_016025.1|WP_014100879.1|166264_166510_+|DUF2281-domain-containing-protein
MTETIARTFPVTAVQSKLPELLAGMAGGEELILTADGVPVAVIKRLERTSWPSVPGTAKDRSFWMSPDFDAPLEDFAEYME
>NC_016025.1|WP_014100878.1|164283_165858_-|tetratricopeptide-repeat-containing-protein
MTKRIQVMVLAAVLCLAGATACTQSNNWETLNRDATELYRAGKYERAITVAKKALEVAEKSVGPDHPNVATTLNILAEIYREQRQYAQAEPLHRRALTIRENALGPDHPSVAQSVNNLAVLYKNQGQYAQAEPLLKRALAIGEKSLGPNHPDVATSLHNLAELYQDKGQYAQAELLCGRALTIREKVLGPDHPDVATSLNNLALLYYAQGQYAQAEPLLKRTQAILEKALGSNHPDVAKSLNNLALLHYGQCQYSQGAPLCERALAIMEKSLGSDHPDVAIIVNNLAVFYHEAAMYTQAVPLYNRSLAIMEKSLGLAHPDVAVILNNMAVFFYDQHAYAQAEPLYQHALDIREKTLDPGHPDVAKSLNSLALLYYEQRQYAQAELLFKRALAIREKALGPEHPDVAATMHNLATLYHAQRKYAQAKPLYRRALTIREKTLGPNHPDVGATAYNLSQVYLLQFQFNQSDSLFHRWMDIERKTWDSIFIGNSLRLPVRFYLVPAKGQIIEVEKLEERAVRIRSTYR
>NC_016025.1|WP_148264083.1|161898_163857_-|tetratricopeptide-repeat-protein
MVKWRQVIALVVMLYLTGAMAYAQGAGREWETLNQEVIKLYQAGKYDRAIVVAKKALEVAEKRVGTEHPNVAKSLTNLAYLYNAQGQYAQAEPLFRRALAIQEKALGPDHPDVATSLNNLAGLYQAQGQYAQAEPLFRRALAIREKALGSDHPDVATSLNNLAGLHQAQGQYAQAEPLYKRALDIREKALGSYHLDVVAILNNLAEIYKAQGQYAQAEPLYKRAMGIQQNVLGLDHPDMATTLNNLAEIYREQGRYDLAEPFLKHSLGILERFLGADHPDVATSLNNLAIIYKAQGQYAQAEPLFKRALAIQENVLGPDHPDVAQSLNNLAALYQAQGQYAQAEPLFKRALTIREKALGSDHPDVATNLNNLALLYEAQGQYAQAEPLFKRALAIREKALGPNHPDVATSLNNLAGLYQAQGQYAQAEPLFRRALAIREKALGSNHPDVATSLNNLAGLYQAQGQYAEAEPLFRRALDIREKALGPNHPDVATSLNNLAGLYQTQGQYAQAEPLFRRALVIREKSLGPNHPDVAAGLNNLAGLYQAQGQYAQAESLHKRTLAIREKVLGPDHPDVATSLNNLAIIYKAQGQYAQAEPFFRRVLAIREKSLGPNHPDVATALRNLAQLYRATKRIAEAEQLEERAAKIKAGDK
>NC_016025.1|WP_014100876.1|161008_161707_-|tetratricopeptide-repeat-containing-protein
MINLVQVMALAAVLCLTGGPAYAQGAGIEWETLIEEVRTLYRAGRYDRAATVAKKALEVAEKRVGLNHPDVATSLNHLAKSHQAQGQYTQAEPLFKRALDILEKTLGPDHPDVATGLNNLAGLYQAQGQYAQAEPLYKRALTITEKATDPDYSVVAMILNNLGRLYDIQGQYAQAEPLFRRSLAIREKVLGPNHPDVATSLENLALLCRLTRRIAEAEKLEERAAKIKANNK
>NC_016025.1|WP_014100875.1|160330_160720_+|type-II-toxin-antitoxin-system-VapC-family-toxin
MRLLLDSHALIWSQDDISQLSPVALAALSDPANDRLISVATVWEIAIKVGKKRLPLSKPFRQWMEIAIADLYLTLLPITLDHTDRQLALPPHHGDPFDRLLISQSLVEGIPIVGSDTQFDAYGVTRIWD
>NC_016025.1|WP_014100874.1|160100_160331_+|antitoxin
MNPLSIQEAQACLADLIHRLSPGEEVILTENGQPVARLVATCTPPPRPVPKLGTQRGSVLSMEHFDDPLEEFEEYQ
>NC_016025.1|WP_014100873.1|158366_159695_-|tetratricopeptide-repeat-protein
MLKRIQVIALAAVLCLTGTIAYAQCAGRKLRELHQEATELFQAGKHDHAVVVAKQALEFAKQSFGPNHPAVAASLNILVLFYANQGQYAQAEPLSKRALVILKKSVGPDHPAVAQNLNTLAGIYLAQGQYTQAEPLFKRALAIWEKALGPDHPDVAASLYNLALLYTNQGQYAQSEPLLKRALAIEEQTLGPNHPDVAASLDKLAMLYTNQGRYAQAEPLLKRALAIGEQTLGPNHPDVAASLDKLAMLYTNQGQYAQAEPLFKRALAIREKVLGPDHPAVAQSLNNLALLYQAQDHHAQAESLLKRALAIEEKALGPDHPAVAQSLNNLAVVYLAQEQYAQAEPLIKRALAIREKALGSDHPAVAQSLNNLACIYRAQGQYAQAEPLIKRALAIREKALGPNHPDVATVLKNLALLYRATQRTTEAEELEARAAKIKANDR
>NC_016025.1|WP_014100883.1|170904_171150_+|DUF2281-domain-containing-protein
MTETIARTFPVTAVQSKLPELLAGMAGGEELILTADGVPVAVIKRLERTSWPSVPGTAKDRPFWMSPDFDAPLEDFAEYME
>NC_016025.1|WP_014100884.1|171146_171296_+|type-II-toxin-antitoxin-system-VapC-family-toxin
MNFDCLTALPFHHRDPFDRMLVAQSLIEGMPLLSADTIFDAYGVNRIWD
>NC_016025.1|WP_041570090.1|171515_172868_-|oxygen-independent-coproporphyrinogen-III-oxidase
MTMRIDQLLQKYSRPGPRYTSYPTVPVWSEQVGAMDYRAALQALSETPDAQNLCLYVHLPFCAMACHYCGCNNAVTSKTEVVDAYLDRVAREVALVVEQLGRGRRVVQMHWGGGTPNTLTARQMERLVRLLEEAFVLDWNGEMSIEIDPRIASPAQLKHIRSLGFRRISLGVQDFHPEVQAAIGRHQPEALTKAVYAACRDVGFESINLDLVYGLPRQTRATFEHTVASVLELHPDRLALFNYAHMPKLRPRQRHIRVEDLPDVITRFAMFDDARQRLTAHEYVWIGMDHFARQDDELAVASHERRLHRNFMGYTLRPAANLIAFGMSGISELEGFYAQNDARLGRYQTALDHGELPVVRGHRLSADDQRRREAIRYLMCHMELPVAVLRDDFERQRAAFREMEADGLICFDAGRLVVTPLGRPFVRNICMTLDAYLETDAPRPVFSKTL
>NC_016025.1|WP_014100886.1|172830_174486_-|magnesium-protoporphyrin-IX-monomethyl-ester-anaerobic-oxidative-cyclase
MKILMLQPNYHCGGAEIAGNWPPSWAPYIGGAIRAAGYTNYRFVDAMALDLSDEAVANIIRTNQPDVVMATAITPMIYKAQDTLKLAKDINPSTVTILGGIHPSFMYGQVLAEAPWIDYIVRGEGEEIIVNLLRAIEAGDDRQRRHEIRGLAFCSDEGNVVATPAHPPIADLDSLTPDWSVLDWSQYIYIPLNVRVAVPNFARGCPFTCRFCSQWKFWRKYRTRSPRKFVDEIETLVKEHQVGFFILADEEPTINQKKFVALCEEMIARKLDVHWGINTRVTDILRDADLLPLYRRAGLVHVSLGTEAATQMNLNRFRKETTIQENRRAIQLLKDNGMVAEAQFIMGLENETPETLQETYRLALDWNPDMANWNMYTPWPFSELFEELKDRVEVRDYSRYNFVTPIMQPDEMEREDVLKGVLKMYGRFYSRKAFLEYPFIRDSFKRKYMLGCLKAFLKMTATKRFYDLGRVKRKGLGVEVDLGFDSSKVFTREQLTALNEGPGAVRADVDYLGSISACGGPREQTVPPTPLVSLGKREQADDEDRPTVAKI
>NC_016025.1|WP_148264086.1|174524_174767_+|hypothetical-protein
MKEKVGVGTRKNTGLNEAFFFQRTAAERQVYNLFRPAKVLCQRSSQPDPAEVSGWKTAAVALPSGALPWFALLFEGVTTV
>NC_016025.1|WP_014100887.1|174995_177788_+|DEAD/DEAH-box-helicase
MTQGRANYFDNWFKKATGRKPFPYQRALAQCGRLPELLEVPTGTGKTAAAILGWLWRRRCHPKETVRNATPRRLVYCLPMRVLVEQTRACAVRWLNNLNLLAGTAIFKGNRLKSYEVDWKQQNKIAVVRLMGGESQRDWREYPEREAIIIGTQDMLLSRALNRGFAMPPQEWPIDFGFLNVDALWVMDEVQLMGPGRTTSVQLQAFWDAAPPSHGLRQTLWMSATLGSQAGSLQLPNWMQTPEKSQLLACQHTNADLQNPAFALRWNAPKRLELHLDSAANNTGVTKPKVKPARGKRKPGSKDDAQAGKPGEQGWTVESPDLHTAILDEANGGRLVLVFVNQVKRARELHDRLRASAGAGAEVLLVHARMRPRDRHAVVSKLGTATPASGRIVVTTQVLEAGVDLDADALFTELCPWPSLVQRLGRLNRSGTRPRSSDVNKGKAKPARAVVFEPVIFEPPSPARKEQESDGDYEERRKRELSWPYEPEAIDEARKLLAQVAEAHDGSLSPKTLSTLSISLPLEGPVLRRFDLDDLFDTDPDLSGGYTDVTPYLRAADRDVDAYLLWRRITGERDADETGERDADETGERDADEQVPFHRGELCPVPFYEAQEAFAEREVWILTLSTGRKGRAAWRKATGREIRAGDTVMVDREAGCYREDVGWTARDADKPNVIIDRCKRDDGKRVRAWVRLDGGTASLVCEIDEHIVGPRARLEDRRCFTKEWMELEPHLLLAEQKAMDLVGRLALNGTVGESVIRAARWHDVGKALERKRNGTFTRPFQEYLRRGGTAVEPHPRNNALYAKSNGRKPGGTSGFRHEMASLLAFLESKHVDDDLAAFLILAHHGKVRLLPEAWDDDDPVDLCGVRDGDRIPAAALPVGNNPIVLNTKIVLPSRQHRGWQGRVHKLLKKHGPFLLAYLEGLVRVADWRAS
>NC_016025.1|WP_014100888.1|177787_179923_+|type-I-U-CRISPR-associated-protein-Csx17
MAAVVLGGVSPRSLGDLLKGFGIMAIVGENCPDALFWWDDAFHLAVERPCDDGADQTKARQAIEDVVRGHLLGWGSVVAEAFKPVRGSKEKKIKRQGSKLKKRDNHDRFEPQIAAWARAIALPDPDKEKTEPHPLFPAHGQEGSGDYFSQVEKAVEAARGAPLDIAWSLFAEGNPKLKKGLDSGYLFFPEPMKRYATGIAKWAQDRAALSPWCFLLAVRGAVLLRGSLRRLRWGRRAYPAFPFVFEGSVVELGKGKFFRNVEIHLPTWNADCPRTLAEFEVQMRQFQARLSGRGFAATAAEFRAAVVGRGPGAAFDTFHRFVLEGRRRGQDQRMRQGIPRGSTRVGVKGKEHATLRLMLAPLAETGWFDQFSTDRLRAERARAEEAIHRAVDEPGPDTYRGILESLWDLNQALVVSGALRRDLEDTRRKPRPLPPLPALLWERALGNGPDPAHRLGRAIGSILGVRADLGVRAEGAVVGPILEHMLPVRYRWDDRAWTVPESPPSRSLRWSGLNPLGDFGDLFWYRWLDSAELPRLPFAAARFARLADIAALLRGDVNIREVHCLAALYALLDWQNHNQPLETEQATASGAGVFLPPSYVALRLWLDLGIDPPPESRPPRDGTVARLLSLGSASGVERAVELALRRLRVNGLPWSTNPRPTGKAVARFAATIPGDEAARMLLAVLVPILKDDTLALSRRLWVPIDEQEAIA
>NC_016025.1|WP_014100889.1|179919_181284_+|type-I-U-CRISPR-associated-protein-Cas7
MTTTPAQSQAQSLLDQLYAQYHIVITASLKLTNGNFLQPTGFPDIGACIYRDKEGRRWCLVESEQSMANRLEAVCMKAPGVWVDDLRGLPVIAVKDKGGKLLATNLTEPHRIASSYILESELAGGNKNLRKLFEEKIGLENRPENNGDFWPMDRRADLERLVFALDPSALLHGFQFVQWKFVGLRQTRLVHARLEAELADDPEVHYVMVKWDGIEPESTRKERANKGQSIAAKSRIVPKNITATFEIDLLALRSLSLADDRKKFLLGLALWKIGAFLNNNQSFDPRSRSTGPSLRLRADCYLTCESISWSGNSSKGQTTPTELMEAKPTGLGQAEGPSFLPDTHGNLPDTHGNDDGKQAGMSGVTFSALIKELLSDKKDEATSGEPKEGKSSAEKGTASGKESSPGNLYDGPMVEVTYDPKQNQENKPKQEKKGGSKAAQQTEANVEQAGEAQE
>NC_016025.1|WP_014100890.1|181280_182837_+|type-I-U-CRISPR-associated-protein-Cas5/Cas6
MTNTTVIEVKLLSGRYHAHVWGESQFGMAGPEWPPSPWRLLRALASAWFCAQPGLSSEIDRDGLLRDGLLRDRLIETLGQSDAPEIWLPRTSVHEIRYYQPVRLGASDRVPHHDHFAVPEGGRFWFRFAKSLPPDQRALLAKLLERLRYFGRSESRARLCLVDRNEPPRSDNIFVVTHHNSGQQVSPTTHYHYRRVLCTVPDKFKASDLWSVQGGCNAGKHPNARSGGYPIHLVDKLIEEKMPLPCGARWVEYAVPAEALVHEIRPRVPAPPAKPSVNVAEIRFRLNRRIPIPLRYVVAVARAFRDAAVEAHRDRTGQMSLILSGRELDGTVARGHQHAYYLPRPRAGAVTLDELLVRVPGGKLTQEELDALLGVGRIRVGGRSYPITVVPEAVVASAKPAPEARQWQSVTPFLPPLRHRQGREETRVDRQAIACAEKVCGRRPAHVESLSGPGGLGCVSPVLAHEYGTGGRGWTLTTRLGFWLQLTFDEPVSLDRPLGADAHFGAGQFAPVDQSEET
>NC_016025.1|WP_041569950.1|183254_183488_+|hypothetical-protein
MSSTAAIMTVTKMLESLPESVQERVVEHLREYLADLQDELKWDSLFEQTQSQLVTAARRAKQDIVQGRAQPMDDEQL

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Crispr_ID: NC_016025_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016025_2

420934-428142

TypeV

I-A,I-B,II-B

Consensus_repeat	Method
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	PILER-CR
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CRISPRCasFinder
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CRT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	PILER-CR

100 spacers

cas2,cas1,cas5,cas7,cas8b3,cas3,cas6,WYL,Cas14c_CAS-V-F

The CRISPR arrays of NC_016025_2

>merge|NC_016025|2|420934-428142|PILER-CR,CRISPRCasFinder,CRT,PILER-CR
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACTGAAAAAGACGAACACTCCGGAGGACGGGAAGCCTGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACAAAGTAAAAGCTTACGTTCCAACCCTGGAGTACACGCGGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACTGAAAGGTTTTGTGCCGGGGTGTGCCCGTTTTCCGGCGGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACCTTCTGCGCCGGGATTGAGCACGCCGTCCACATCACTGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACCTCCCGCCATTCACTTCCACTTGCACCGATTGCCGCCAGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACGACTGCACAACCGACAACGCAAACTGCTTGAACGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACCGGCGTCAGGACGACTTCACGCTGGGCGTGCGCGAGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACCTCTCAGCGCCCACCATCGTTGATTACACCCGCAGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACGCGATAATGACGGCGATCAGCGGGAACGGCATCAGATGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACTCGTAGTGATTGCCGGCCATCTCGTAGACGGCTTTCAGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACTGTGGCTATAGTACACGTGCGCATTGAGCTTGACAGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACTCCATTACGTTTATCGCGTGCCGCAATCCCGTCAAGCCGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACAACCACGCTTCGCCGCGCATATCGGTAAGCGTCGGCGCGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACAGCTTGCGGCGTTGCGTTACTCGTACCAGCGGGGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACGCAATCAGCGGGAAAGGCATCAGATTATCCCCCCCGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACCAGGGGTTGCCCTTGTGTTGCACAAACCAGTCGTGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACGCAGGCTTACCGCCGCCCAACTCTGTCAAGTGCTTGAACGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACCCTTGCCGTCTCCCCTTTATTCCTGCCTTGCCAGGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACTTCGGCGCACGCTGAAGGTCTGTCCCCCAGACGAGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACCGGTTTTTGTGAATTCGACGGTTGGCGGCTGAAAGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACGCCAAGCCGGCGCAGGGAAAACGTCGCTCATCCCGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACTTAGGAAACCGCACCAAGACGCGAACAAGCCCGGCGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACACAATGGCGATCAAGGGAAACGGCATTAGATTACCCCTGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACACCACGTCGCCGGGCCACGTGATACCAAATAAGCAGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACTACGCGCGGCGTTGCGCGTCATTCAAATGCGACAGAGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACACGGCCTTGATTTCGTCTTCGATATTCCGGCGTCGAGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACATACCGCTCCGCCGGAATTGTGGTTGGAGCTGGACGGCAGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACCAGACGAGTGGCAGATACAGCTACCGTCTGCCCTTTGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACTCAATCAGGAAAAACCAGCCACGCACCGTCGCGGCGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACTACCAGCCGGACTTGTCACGCTTTTCGCCCGTATTGTGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACGCGCTTGTTACGCCGTATTGGGCAAGGAATCGAGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACTTTGGGAAGCGGGTGGTGGGATTACCCGTCATTCTGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACGTTCGCTCTTATTACTTCAGCGGCAAGTACTACGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACTCCACGATGGGCCGGTAGTCCAGTCGCGCGCACTCTTGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACACCATGTACACAAAGTACACACCGGATAACCTAACCCAGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACGTGGTATTGCCGCCTGCTGCACGACTGGGCATGGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACCCCTTTTTGTGGCGCCTTGAAGCCGATCTTGTTCTTTGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACGCAAATCTGGACGCAACTTTGATTGGCGCTGCGCCGGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACAAGCGGCACGGGAGAAACCAGGAACTCGCCAGTATGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACTGGTGCTCCGCCTGACGCGGTATCTCACGGCTGTCGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACAACGTTTTGTCAAGGGGAAAGTTCCGATTTTTTTGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACGCCGGCAATCACTACGACATCTGGGTTGGGTACGTGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACGCTGGCTGGCGTGGGCTGTGCAAGGGGAACTTTTGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACTCCACGATTGGTCGGTAGTTCACTCGCATGCACTCGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACTTGTCGACCGCCGGGAAAGCAGCCGGCGGAGTGTCGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACGTGGCAGGCGCGGTTTCTGAAGGCCCTACCCGCTATGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACGTGTGGGTTTGAGATTCGCAACCGGGCCTTCAAAGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACCGCACCTGAGGAAGTGGATAGAACGACTGTCGAAAGAGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACGACTCGTTACTTGACGAGTCCACGCCAGATTAAGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACCGCTGAACTACGTTTTGGCTAAGGTCAATCAACTGGGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACAAAAACTCAAGCTCTTGCGCAAGCGCATGGGCGGCAGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACGATTTCGCCTATGCGAAGACGCTTGCGCGGAGATAGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACAAGAAGCCCAAGCGCAGGCGCGGATTATTGACCTGACCAGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACGCGGTAATCGTGATTATAACGCCTGAAGCGCGGGGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACCGGACAAGTGGCAGATACAGCTACCGTCCGCCTTTGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACACCGCGCCGGTTTTTCCGTTTGAGCCAAACTGGGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACCCCGTCGCTGGTCAAGGAGCGGGTCAAGGGGCGTCCGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACACGGCGTGCACTGGGTACTTTGCTTTCCCGTCGAAGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACACCGGGTCTGACCCATATATTGCATCACGAGTGCGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACTGTTCTCAACCGAAATCACCGTATCCGACGGGTTGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACACGGTTGGCTTCAACATGGCGTTTCAATCCTGGGTGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACGACGCGGTGATTCGTGAGGCAATCAAAGACAGGATTGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACCACGCTGCCGTTGCTGCTGGCGGGCTGGACAAGCTGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACGGCCGCTATCTGCACCTGCAGGGGAAGGTGTATTACGCGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACCGGTGTGCTATGCAGTGTGGGGCTGGCGTCCACGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACTACGGGAGACGGCGCAGAAGCTCCCCTAAAGCGTGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACTCACACGCTTCTACGCGAATTCACAGACCGGGAATGGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACACCGGCGAGAGACCGTTTCTATCCTGCCTTGGGATAGTGCAAAAATCTTTGATGCCGAAAGGCATTGATCACATTTCAGCCGAGCGACCGCCGCTTGGATTTGTTCACGAGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACGCCATCGCAGTCAAGAGCACTCGCTCGCTCTCGCAACAGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACTTATCACAGCGCGCCTCGACCGCAAAGTTGACGCAAAGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACCTGTCACACGTGCTGGGAGTACACACCAGAGGGGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACTGGTTTCTCCTTTCCCGCATAAAACGGCTTCGAGTGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACCGATTGCGTCAGCGTCACGCACCTTGTCTTTGACAGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACGCGAACTCGTCTTGGTGCGTGTCGTTATCCGGGAGACAGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACTTGACCGGAGACTGCTGCGAACCAACCTTGTTGGCGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACATCTCTGGGTCGGATACGTCCGACCCAACACAGCCGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACGCAGTTGCACCGCCGCCGAGAAAACTTGCGGCTTGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACCACACCATAGTACTGCTTCCACGCAAGAGCGCGTCGGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACAGCAGGCTGTAGTGTTTTCCATCCAGTCTTGCGACTGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACATCGCCCCTAAGTCTGGCGGCTCCCAAGTGTCCAGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACTAGACTTTTGCGAGTTTCAGCGACATAAGGCGGGTCAGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACAATCGCTGCTCGCACGGGTGCTTTTACTGTTTCGCGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACCTTCAGTTAGAGGCCCTTCAAGACTTGCTCAATCAGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACGGCCGCATCCTGTACTCGCCGTCAATGCCGGGCCGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACGACGGCGGCCAAGATCAGTCCGAAACACGCCGTCGGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACGCCCATGAGGTTTCGTTTCTTTTTTCGATCTGCGAGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACCTCCCTTTTTTTCTGCTTGTAGAGAAGGCGCCTAGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACTCAACGAAACCCGTAAAACCCTGAACGCCTACGCAGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACAGACGGGACTGACTACGGCTTACCCAGCCTGGTTGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACCTTGCCAAACTTCTACCGCTACTTCCAGCGCATAAGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACGCCAGCCGGTAAGAATCAAGCTGGTCTAGTTCTAACGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACTCCGACAAGCCAATTGGCGCGGTCAAACGCAGGTCAGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACGCCGGGCGGGGGCTACGCCCGAAATCTCACACCGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACATACCAAGTATAATAGACTTCTGTGCGAAGTTGTAGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACTGCTGACGGTTGTGGACGACAGCGAGGATGATTCGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACCACCCGTCACGCGGGTGCGAGTGCCGGAAGGCACTGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACTTTGATTCGGTCTCAATCGAGCACGAACGCGCGTTTGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACCGGCCGAAATACCGGCCATATTTCCGCGCTGGCTTGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACTTAAAACCGGCGAATGGCGAATGGTAGATGTATGAAACTCTCTGATGCTGAGAAATGTTGATCAC

>NC_016025|2|1|420934-424854|PILER-CR
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TGAAAAAGACGAACACTCCGGAGGACGGGAAGCCT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AAAGTAAAAGCTTACGTTCCAACCCTGGAGTACACGCGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TGAAAGGTTTTGTGCCGGGGTGTGCCCGTTTTCCGGCGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CTTCTGCGCCGGGATTGAGCACGCCGTCCACATCACT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CTCCCGCCATTCACTTCCACTTGCACCGATTGCCGCCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GACTGCACAACCGACAACGCAAACTGCTTGAACG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CGGCGTCAGGACGACTTCACGCTGGGCGTGCGCGA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CTCTCAGCGCCCACCATCGTTGATTACACCCGCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCGATAATGACGGCGATCAGCGGGAACGGCATCAGAT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TCGTAGTGATTGCCGGCCATCTCGTAGACGGCTTTCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TGTGGCTATAGTACACGTGCGCATTGAGCTTGACA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TCCATTACGTTTATCGCGTGCCGCAATCCCGTCAAGCC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AACCACGCTTCGCCGCGCATATCGGTAAGCGTCGGCGC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AGCTTGCGGCGTTGCGTTACTCGTACCAGCGGGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCAATCAGCGGGAAAGGCATCAGATTATCCCCCCC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CAGGGGTTGCCCTTGTGTTGCACAAACCAGTCGT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCAGGCTTACCGCCGCCCAACTCTGTCAAGTGCTTGAAC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CCTTGCCGTCTCCCCTTTATTCCTGCCTTGCCAGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TTCGGCGCACGCTGAAGGTCTGTCCCCCAGACGA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CGGTTTTTGTGAATTCGACGGTTGGCGGCTGAAAG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCCAAGCCGGCGCAGGGAAAACGTCGCTCATCCCG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TTAGGAAACCGCACCAAGACGCGAACAAGCCCGGC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ACAATGGCGATCAAGGGAAACGGCATTAGATTACCCCT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ACCACGTCGCCGGGCCACGTGATACCAAATAAGCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TACGCGCGGCGTTGCGCGTCATTCAAATGCGACAGA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ACGGCCTTGATTTCGTCTTCGATATTCCGGCGTCGA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ATACCGCTCCGCCGGAATTGTGGTTGGAGCTGGACGGCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CAGACGAGTGGCAGATACAGCTACCGTCTGCCCTTT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TCAATCAGGAAAAACCAGCCACGCACCGTCGCGGC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TACCAGCCGGACTTGTCACGCTTTTCGCCCGTATTGT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCGCTTGTTACGCCGTATTGGGCAAGGAATCGAG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TTTGGGAAGCGGGTGGTGGGATTACCCGTCATTCTG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GTTCGCTCTTATTACTTCAGCGGCAAGTACTACG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TCCACGATGGGCCGGTAGTCCAGTCGCGCGCACTCTTG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ACCATGTACACAAAGTACACACCGGATAACCTAACCCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GTGGTATTGCCGCCTGCTGCACGACTGGGCATGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CCCTTTTTGTGGCGCCTTGAAGCCGATCTTGTTCTTT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCAAATCTGGACGCAACTTTGATTGGCGCTGCGCCGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AAGCGGCACGGGAGAAACCAGGAACTCGCCAGTAT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TGGTGCTCCGCCTGACGCGGTATCTCACGGCTGTC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AACGTTTTGTCAAGGGGAAAGTTCCGATTTTTTT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCCGGCAATCACTACGACATCTGGGTTGGGTACGT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCTGGCTGGCGTGGGCTGTGCAAGGGGAACTTTTG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TCCACGATTGGTCGGTAGTTCACTCGCATGCACTC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TTGTCGACCGCCGGGAAAGCAGCCGGCGGAGTGTCG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GTGGCAGGCGCGGTTTCTGAAGGCCCTACCCGCTAT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GTGTGGGTTTGAGATTCGCAACCGGGCCTTCAAAG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CGCACCTGAGGAAGTGGATAGAACGACTGTCGAAAGA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GACTCGTTACTTGACGAGTCCACGCCAGATTAAG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CGCTGAACTACGTTTTGGCTAAGGTCAATCAACTGGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AAAAACTCAAGCTCTTGCGCAAGCGCATGGGCGGCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GATTTCGCCTATGCGAAGACGCTTGCGCGGAGATA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AAGAAGCCCAAGCGCAGGCGCGGATTATTGACCTGACCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCGGTAATCGTGATTATAACGCCTGAAGCGCGGGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACCGGACAAGTGGCAGATACAGCTACCGTCCGCCTTTGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACACCGCGCCGGTTTTTCCGTTTGAGCCAAACTGGGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CCCGTCGCTGGTCAAGGAGCGGGTCAAGGGGCGTCC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ACGGCGTGCACTGGGTACTTTGCTTTCCCGTCGAA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ACCGGGTCTGACCCATATATTGCATCACGAGTGC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TGTTCTCAACCGAAATCACCGTATCCGACGGGTTG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ACGGTTGGCTTCAACATGGCGTTTCAATCCTGGGTG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GACGCGGTGATTCGTGAGGCAATCAAAGACAGGATT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CACGCTGCCGTTGCTGCTGGCGGGCTGGACAAGCTG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GGCCGCTATCTGCACCTGCAGGGGAAGGTGTATTACGC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CGGTGTGCTATGCAGTGTGGGGCTGGCGTCCACG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TACGGGAGACGGCGCAGAAGCTCCCCTAAAGCGT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TCACACGCTTCTACGCGAATTCACAGACCGGGAATGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ACCGGCGAGAGACCGTTTCTATCCTGCCTTGGGATA
GTGCAAAAATCTTTGATGCCGAAAGGCATTGATCAC	ATTTCAGCCGAGCGACCGCCGCTTGGATTTGTTCACGA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCCATCGCAGTCAAGAGCACTCGCTCGCTCTCGCAACA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TTATCACAGCGCGCCTCGACCGCAAAGTTGACGCAAAG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CTGTCACACGTGCTGGGAGTACACACCAGAGGGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TGGTTTCTCCTTTCCCGCATAAAACGGCTTCGAGTG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CGATTGCGTCAGCGTCACGCACCTTGTCTTTGACAG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCGAACTCGTCTTGGTGCGTGTCGTTATCCGGGAGACA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TTGACCGGAGACTGCTGCGAACCAACCTTGTTGGCG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ATCTCTGGGTCGGATACGTCCGACCCAACACAGCCG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCAGTTGCACCGCCGCCGAGAAAACTTGCGGCTT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CACACCATAGTACTGCTTCCACGCAAGAGCGCGTCGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AGCAGGCTGTAGTGTTTTCCATCCAGTCTTGCGACTG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ATCGCCCCTAAGTCTGGCGGCTCCCAAGTGTCCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TAGACTTTTGCGAGTTTCAGCGACATAAGGCGGGTCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AATCGCTGCTCGCACGGGTGCTTTTACTGTTTCGC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CTTCAGTTAGAGGCCCTTCAAGACTTGCTCAATCAG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GGCCGCATCCTGTACTCGCCGTCAATGCCGGGCC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GACGGCGGCCAAGATCAGTCCGAAACACGCCGTCGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCCCATGAGGTTTCGTTTCTTTTTTCGATCTGCGA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CTCCCTTTTTTTCTGCTTGTAGAGAAGGCGCCTA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TCAACGAAACCCGTAAAACCCTGAACGCCTACGCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AGACGGGACTGACTACGGCTTACCCAGCCTGGTT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CTTGCCAAACTTCTACCGCTACTTCCAGCGCATAAG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCCAGCCGGTAAGAATCAAGCTGGTCTAGTTCTAAC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TCCGACAAGCCAATTGGCGCGGTCAAACGCAGGTCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCCGGGCGGGGGCTACGCCCGAAATCTCACACCG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ATACCAAGTATAATAGACTTCTGTGCGAAGTTGTA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TGCTGACGGTTGTGGACGACAGCGAGGATGATTCG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CACCCGTCACGCGGGTGCGAGTGCCGGAAGGCACTG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TTTGATTCGGTCTCAATCGAGCACGAACGCGCGTTT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CGGCCGAAATACCGGCCATATTTCCGCGCTGGCTT


>NC_016025|2|2|420934-428142|CRISPRCasFinder
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TGAAAAAGACGAACACTCCGGAGGACGGGAAGCCT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AAAGTAAAAGCTTACGTTCCAACCCTGGAGTACACGCGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TGAAAGGTTTTGTGCCGGGGTGTGCCCGTTTTCCGGCGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CTTCTGCGCCGGGATTGAGCACGCCGTCCACATCACT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CTCCCGCCATTCACTTCCACTTGCACCGATTGCCGCCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GACTGCACAACCGACAACGCAAACTGCTTGAACG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CGGCGTCAGGACGACTTCACGCTGGGCGTGCGCGA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CTCTCAGCGCCCACCATCGTTGATTACACCCGCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCGATAATGACGGCGATCAGCGGGAACGGCATCAGAT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TCGTAGTGATTGCCGGCCATCTCGTAGACGGCTTTCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TGTGGCTATAGTACACGTGCGCATTGAGCTTGACA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TCCATTACGTTTATCGCGTGCCGCAATCCCGTCAAGCC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AACCACGCTTCGCCGCGCATATCGGTAAGCGTCGGCGC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AGCTTGCGGCGTTGCGTTACTCGTACCAGCGGGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCAATCAGCGGGAAAGGCATCAGATTATCCCCCCC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CAGGGGTTGCCCTTGTGTTGCACAAACCAGTCGT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCAGGCTTACCGCCGCCCAACTCTGTCAAGTGCTTGAAC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CCTTGCCGTCTCCCCTTTATTCCTGCCTTGCCAGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TTCGGCGCACGCTGAAGGTCTGTCCCCCAGACGA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CGGTTTTTGTGAATTCGACGGTTGGCGGCTGAAAG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCCAAGCCGGCGCAGGGAAAACGTCGCTCATCCCG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TTAGGAAACCGCACCAAGACGCGAACAAGCCCGGC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ACAATGGCGATCAAGGGAAACGGCATTAGATTACCCCT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ACCACGTCGCCGGGCCACGTGATACCAAATAAGCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TACGCGCGGCGTTGCGCGTCATTCAAATGCGACAGA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ACGGCCTTGATTTCGTCTTCGATATTCCGGCGTCGA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ATACCGCTCCGCCGGAATTGTGGTTGGAGCTGGACGGCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CAGACGAGTGGCAGATACAGCTACCGTCTGCCCTTT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TCAATCAGGAAAAACCAGCCACGCACCGTCGCGGC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TACCAGCCGGACTTGTCACGCTTTTCGCCCGTATTGT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCGCTTGTTACGCCGTATTGGGCAAGGAATCGAG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TTTGGGAAGCGGGTGGTGGGATTACCCGTCATTCTG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GTTCGCTCTTATTACTTCAGCGGCAAGTACTACG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TCCACGATGGGCCGGTAGTCCAGTCGCGCGCACTCTTG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ACCATGTACACAAAGTACACACCGGATAACCTAACCCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GTGGTATTGCCGCCTGCTGCACGACTGGGCATGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CCCTTTTTGTGGCGCCTTGAAGCCGATCTTGTTCTTT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCAAATCTGGACGCAACTTTGATTGGCGCTGCGCCGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AAGCGGCACGGGAGAAACCAGGAACTCGCCAGTAT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TGGTGCTCCGCCTGACGCGGTATCTCACGGCTGTC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AACGTTTTGTCAAGGGGAAAGTTCCGATTTTTTT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCCGGCAATCACTACGACATCTGGGTTGGGTACGT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCTGGCTGGCGTGGGCTGTGCAAGGGGAACTTTTG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TCCACGATTGGTCGGTAGTTCACTCGCATGCACTC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TTGTCGACCGCCGGGAAAGCAGCCGGCGGAGTGTCG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GTGGCAGGCGCGGTTTCTGAAGGCCCTACCCGCTAT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GTGTGGGTTTGAGATTCGCAACCGGGCCTTCAAAG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CGCACCTGAGGAAGTGGATAGAACGACTGTCGAAAGA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GACTCGTTACTTGACGAGTCCACGCCAGATTAAG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CGCTGAACTACGTTTTGGCTAAGGTCAATCAACTGGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AAAAACTCAAGCTCTTGCGCAAGCGCATGGGCGGCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GATTTCGCCTATGCGAAGACGCTTGCGCGGAGATA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AAGAAGCCCAAGCGCAGGCGCGGATTATTGACCTGACCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCGGTAATCGTGATTATAACGCCTGAAGCGCGGGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CGGACAAGTGGCAGATACAGCTACCGTCCGCCTTT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ACCGCGCCGGTTTTTCCGTTTGAGCCAAACTGGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CCCGTCGCTGGTCAAGGAGCGGGTCAAGGGGCGTCC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ACGGCGTGCACTGGGTACTTTGCTTTCCCGTCGAA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ACCGGGTCTGACCCATATATTGCATCACGAGTGC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TGTTCTCAACCGAAATCACCGTATCCGACGGGTTG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ACGGTTGGCTTCAACATGGCGTTTCAATCCTGGGTG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GACGCGGTGATTCGTGAGGCAATCAAAGACAGGATT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CACGCTGCCGTTGCTGCTGGCGGGCTGGACAAGCTG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GGCCGCTATCTGCACCTGCAGGGGAAGGTGTATTACGC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CGGTGTGCTATGCAGTGTGGGGCTGGCGTCCACG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TACGGGAGACGGCGCAGAAGCTCCCCTAAAGCGT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TCACACGCTTCTACGCGAATTCACAGACCGGGAATGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ACCGGCGAGAGACCGTTTCTATCCTGCCTTGGGATA
GTGCAAAAATCTTTGATGCCGAAAGGCATTGATCAC	ATTTCAGCCGAGCGACCGCCGCTTGGATTTGTTCACGA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCCATCGCAGTCAAGAGCACTCGCTCGCTCTCGCAACA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TTATCACAGCGCGCCTCGACCGCAAAGTTGACGCAAAG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CTGTCACACGTGCTGGGAGTACACACCAGAGGGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TGGTTTCTCCTTTCCCGCATAAAACGGCTTCGAGTG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CGATTGCGTCAGCGTCACGCACCTTGTCTTTGACAG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCGAACTCGTCTTGGTGCGTGTCGTTATCCGGGAGACA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TTGACCGGAGACTGCTGCGAACCAACCTTGTTGGCG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ATCTCTGGGTCGGATACGTCCGACCCAACACAGCCG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCAGTTGCACCGCCGCCGAGAAAACTTGCGGCTT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CACACCATAGTACTGCTTCCACGCAAGAGCGCGTCGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AGCAGGCTGTAGTGTTTTCCATCCAGTCTTGCGACTG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ATCGCCCCTAAGTCTGGCGGCTCCCAAGTGTCCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TAGACTTTTGCGAGTTTCAGCGACATAAGGCGGGTCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AATCGCTGCTCGCACGGGTGCTTTTACTGTTTCGC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CTTCAGTTAGAGGCCCTTCAAGACTTGCTCAATCAG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GGCCGCATCCTGTACTCGCCGTCAATGCCGGGCC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GACGGCGGCCAAGATCAGTCCGAAACACGCCGTCGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCCCATGAGGTTTCGTTTCTTTTTTCGATCTGCGA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CTCCCTTTTTTTCTGCTTGTAGAGAAGGCGCCTA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TCAACGAAACCCGTAAAACCCTGAACGCCTACGCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AGACGGGACTGACTACGGCTTACCCAGCCTGGTT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CTTGCCAAACTTCTACCGCTACTTCCAGCGCATAAG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCCAGCCGGTAAGAATCAAGCTGGTCTAGTTCTAAC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TCCGACAAGCCAATTGGCGCGGTCAAACGCAGGTCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCCGGGCGGGGGCTACGCCCGAAATCTCACACCG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ATACCAAGTATAATAGACTTCTGTGCGAAGTTGTA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TGCTGACGGTTGTGGACGACAGCGAGGATGATTCG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CACCCGTCACGCGGGTGCGAGTGCCGGAAGGCACTG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TTTGATTCGGTCTCAATCGAGCACGAACGCGCGTTT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CGGCCGAAATACCGGCCATATTTCCGCGCTGGCTT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TTAAAACCGGCGAATGGCGAATGGTAGAT
GTATGAAACTCTCTGATGCTGAGAAATGTTGATCAC

>NC_016025|2|1|420934-428142|CRT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TGAAAAAGACGAACACTCCGGAGGACGGGAAGCCT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AAAGTAAAAGCTTACGTTCCAACCCTGGAGTACACGCGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TGAAAGGTTTTGTGCCGGGGTGTGCCCGTTTTCCGGCGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CTTCTGCGCCGGGATTGAGCACGCCGTCCACATCACT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CTCCCGCCATTCACTTCCACTTGCACCGATTGCCGCCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GACTGCACAACCGACAACGCAAACTGCTTGAACG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CGGCGTCAGGACGACTTCACGCTGGGCGTGCGCGA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CTCTCAGCGCCCACCATCGTTGATTACACCCGCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCGATAATGACGGCGATCAGCGGGAACGGCATCAGAT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TCGTAGTGATTGCCGGCCATCTCGTAGACGGCTTTCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TGTGGCTATAGTACACGTGCGCATTGAGCTTGACA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TCCATTACGTTTATCGCGTGCCGCAATCCCGTCAAGCC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AACCACGCTTCGCCGCGCATATCGGTAAGCGTCGGCGC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AGCTTGCGGCGTTGCGTTACTCGTACCAGCGGGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCAATCAGCGGGAAAGGCATCAGATTATCCCCCCC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CAGGGGTTGCCCTTGTGTTGCACAAACCAGTCGT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCAGGCTTACCGCCGCCCAACTCTGTCAAGTGCTTGAAC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CCTTGCCGTCTCCCCTTTATTCCTGCCTTGCCAGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TTCGGCGCACGCTGAAGGTCTGTCCCCCAGACGA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CGGTTTTTGTGAATTCGACGGTTGGCGGCTGAAAG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCCAAGCCGGCGCAGGGAAAACGTCGCTCATCCCG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TTAGGAAACCGCACCAAGACGCGAACAAGCCCGGC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ACAATGGCGATCAAGGGAAACGGCATTAGATTACCCCT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ACCACGTCGCCGGGCCACGTGATACCAAATAAGCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TACGCGCGGCGTTGCGCGTCATTCAAATGCGACAGA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ACGGCCTTGATTTCGTCTTCGATATTCCGGCGTCGA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ATACCGCTCCGCCGGAATTGTGGTTGGAGCTGGACGGCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CAGACGAGTGGCAGATACAGCTACCGTCTGCCCTTT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TCAATCAGGAAAAACCAGCCACGCACCGTCGCGGC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TACCAGCCGGACTTGTCACGCTTTTCGCCCGTATTGT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCGCTTGTTACGCCGTATTGGGCAAGGAATCGAG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TTTGGGAAGCGGGTGGTGGGATTACCCGTCATTCTG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GTTCGCTCTTATTACTTCAGCGGCAAGTACTACG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TCCACGATGGGCCGGTAGTCCAGTCGCGCGCACTCTTG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ACCATGTACACAAAGTACACACCGGATAACCTAACCCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GTGGTATTGCCGCCTGCTGCACGACTGGGCATGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CCCTTTTTGTGGCGCCTTGAAGCCGATCTTGTTCTTT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCAAATCTGGACGCAACTTTGATTGGCGCTGCGCCGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AAGCGGCACGGGAGAAACCAGGAACTCGCCAGTAT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TGGTGCTCCGCCTGACGCGGTATCTCACGGCTGTC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AACGTTTTGTCAAGGGGAAAGTTCCGATTTTTTT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCCGGCAATCACTACGACATCTGGGTTGGGTACGT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCTGGCTGGCGTGGGCTGTGCAAGGGGAACTTTTG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TCCACGATTGGTCGGTAGTTCACTCGCATGCACTC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TTGTCGACCGCCGGGAAAGCAGCCGGCGGAGTGTCG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GTGGCAGGCGCGGTTTCTGAAGGCCCTACCCGCTAT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GTGTGGGTTTGAGATTCGCAACCGGGCCTTCAAAG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CGCACCTGAGGAAGTGGATAGAACGACTGTCGAAAGA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GACTCGTTACTTGACGAGTCCACGCCAGATTAAG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CGCTGAACTACGTTTTGGCTAAGGTCAATCAACTGGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AAAAACTCAAGCTCTTGCGCAAGCGCATGGGCGGCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GATTTCGCCTATGCGAAGACGCTTGCGCGGAGATA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AAGAAGCCCAAGCGCAGGCGCGGATTATTGACCTGACCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCGGTAATCGTGATTATAACGCCTGAAGCGCGGGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CGGACAAGTGGCAGATACAGCTACCGTCCGCCTTT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ACCGCGCCGGTTTTTCCGTTTGAGCCAAACTGGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CCCGTCGCTGGTCAAGGAGCGGGTCAAGGGGCGTCC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ACGGCGTGCACTGGGTACTTTGCTTTCCCGTCGAA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ACCGGGTCTGACCCATATATTGCATCACGAGTGC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TGTTCTCAACCGAAATCACCGTATCCGACGGGTTG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ACGGTTGGCTTCAACATGGCGTTTCAATCCTGGGTG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GACGCGGTGATTCGTGAGGCAATCAAAGACAGGATT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CACGCTGCCGTTGCTGCTGGCGGGCTGGACAAGCTG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GGCCGCTATCTGCACCTGCAGGGGAAGGTGTATTACGC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CGGTGTGCTATGCAGTGTGGGGCTGGCGTCCACG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TACGGGAGACGGCGCAGAAGCTCCCCTAAAGCGT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TCACACGCTTCTACGCGAATTCACAGACCGGGAATGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ACCGGCGAGAGACCGTTTCTATCCTGCCTTGGGATA
GTGCAAAAATCTTTGATGCCGAAAGGCATTGATCAC	ATTTCAGCCGAGCGACCGCCGCTTGGATTTGTTCACGA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCCATCGCAGTCAAGAGCACTCGCTCGCTCTCGCAACA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TTATCACAGCGCGCCTCGACCGCAAAGTTGACGCAAAG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CTGTCACACGTGCTGGGAGTACACACCAGAGGGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TGGTTTCTCCTTTCCCGCATAAAACGGCTTCGAGTG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CGATTGCGTCAGCGTCACGCACCTTGTCTTTGACAG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCGAACTCGTCTTGGTGCGTGTCGTTATCCGGGAGACA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TTGACCGGAGACTGCTGCGAACCAACCTTGTTGGCG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ATCTCTGGGTCGGATACGTCCGACCCAACACAGCCG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCAGTTGCACCGCCGCCGAGAAAACTTGCGGCTT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CACACCATAGTACTGCTTCCACGCAAGAGCGCGTCGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AGCAGGCTGTAGTGTTTTCCATCCAGTCTTGCGACTG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ATCGCCCCTAAGTCTGGCGGCTCCCAAGTGTCCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TAGACTTTTGCGAGTTTCAGCGACATAAGGCGGGTCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AATCGCTGCTCGCACGGGTGCTTTTACTGTTTCGC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CTTCAGTTAGAGGCCCTTCAAGACTTGCTCAATCAG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GGCCGCATCCTGTACTCGCCGTCAATGCCGGGCC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GACGGCGGCCAAGATCAGTCCGAAACACGCCGTCGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCCCATGAGGTTTCGTTTCTTTTTTCGATCTGCGA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CTCCCTTTTTTTCTGCTTGTAGAGAAGGCGCCTA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TCAACGAAACCCGTAAAACCCTGAACGCCTACGCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AGACGGGACTGACTACGGCTTACCCAGCCTGGTT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CTTGCCAAACTTCTACCGCTACTTCCAGCGCATAAG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCCAGCCGGTAAGAATCAAGCTGGTCTAGTTCTAAC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TCCGACAAGCCAATTGGCGCGGTCAAACGCAGGTCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCCGGGCGGGGGCTACGCCCGAAATCTCACACCG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ATACCAAGTATAATAGACTTCTGTGCGAAGTTGTA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TGCTGACGGTTGTGGACGACAGCGAGGATGATTCG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CACCCGTCACGCGGGTGCGAGTGCCGGAAGGCACTG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TTTGATTCGGTCTCAATCGAGCACGAACGCGCGTTT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CGGCCGAAATACCGGCCATATTTCCGCGCTGGCTT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TTAAAACCGGCGAATGGCGAATGGTAGAT
GTATGAAACTCTCTGATGCTGAGAAATGTTGATCAC

>NC_016025|2|2|424960-428077|PILER-CR
	TGAAAAAGACGAACACTCCGGAGGACGGGAAGCCT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AAAGTAAAAGCTTACGTTCCAACCCTGGAGTACACGCGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TGAAAGGTTTTGTGCCGGGGTGTGCCCGTTTTCCGGCGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CTTCTGCGCCGGGATTGAGCACGCCGTCCACATCACT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CTCCCGCCATTCACTTCCACTTGCACCGATTGCCGCCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GACTGCACAACCGACAACGCAAACTGCTTGAACG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CGGCGTCAGGACGACTTCACGCTGGGCGTGCGCGA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CTCTCAGCGCCCACCATCGTTGATTACACCCGCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCGATAATGACGGCGATCAGCGGGAACGGCATCAGAT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TCGTAGTGATTGCCGGCCATCTCGTAGACGGCTTTCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TGTGGCTATAGTACACGTGCGCATTGAGCTTGACA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TCCATTACGTTTATCGCGTGCCGCAATCCCGTCAAGCC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AACCACGCTTCGCCGCGCATATCGGTAAGCGTCGGCGC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AGCTTGCGGCGTTGCGTTACTCGTACCAGCGGGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCAATCAGCGGGAAAGGCATCAGATTATCCCCCCC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CAGGGGTTGCCCTTGTGTTGCACAAACCAGTCGT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCAGGCTTACCGCCGCCCAACTCTGTCAAGTGCTTGAAC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CCTTGCCGTCTCCCCTTTATTCCTGCCTTGCCAGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TTCGGCGCACGCTGAAGGTCTGTCCCCCAGACGA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CGGTTTTTGTGAATTCGACGGTTGGCGGCTGAAAG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCCAAGCCGGCGCAGGGAAAACGTCGCTCATCCCG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TTAGGAAACCGCACCAAGACGCGAACAAGCCCGGC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ACAATGGCGATCAAGGGAAACGGCATTAGATTACCCCT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ACCACGTCGCCGGGCCACGTGATACCAAATAAGCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TACGCGCGGCGTTGCGCGTCATTCAAATGCGACAGA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ACGGCCTTGATTTCGTCTTCGATATTCCGGCGTCGA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ATACCGCTCCGCCGGAATTGTGGTTGGAGCTGGACGGCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CAGACGAGTGGCAGATACAGCTACCGTCTGCCCTTT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TCAATCAGGAAAAACCAGCCACGCACCGTCGCGGC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TACCAGCCGGACTTGTCACGCTTTTCGCCCGTATTGT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCGCTTGTTACGCCGTATTGGGCAAGGAATCGAG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TTTGGGAAGCGGGTGGTGGGATTACCCGTCATTCTG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GTTCGCTCTTATTACTTCAGCGGCAAGTACTACG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TCCACGATGGGCCGGTAGTCCAGTCGCGCGCACTCTTG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ACCATGTACACAAAGTACACACCGGATAACCTAACCCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GTGGTATTGCCGCCTGCTGCACGACTGGGCATGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CCCTTTTTGTGGCGCCTTGAAGCCGATCTTGTTCTTT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCAAATCTGGACGCAACTTTGATTGGCGCTGCGCCGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AAGCGGCACGGGAGAAACCAGGAACTCGCCAGTAT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TGGTGCTCCGCCTGACGCGGTATCTCACGGCTGTC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AACGTTTTGTCAAGGGGAAAGTTCCGATTTTTTT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCCGGCAATCACTACGACATCTGGGTTGGGTACGT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCTGGCTGGCGTGGGCTGTGCAAGGGGAACTTTTG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TCCACGATTGGTCGGTAGTTCACTCGCATGCACTC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TTGTCGACCGCCGGGAAAGCAGCCGGCGGAGTGTCG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GTGGCAGGCGCGGTTTCTGAAGGCCCTACCCGCTAT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GTGTGGGTTTGAGATTCGCAACCGGGCCTTCAAAG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CGCACCTGAGGAAGTGGATAGAACGACTGTCGAAAGA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GACTCGTTACTTGACGAGTCCACGCCAGATTAAG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CGCTGAACTACGTTTTGGCTAAGGTCAATCAACTGGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AAAAACTCAAGCTCTTGCGCAAGCGCATGGGCGGCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GATTTCGCCTATGCGAAGACGCTTGCGCGGAGATA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AAGAAGCCCAAGCGCAGGCGCGGATTATTGACCTGACCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCGGTAATCGTGATTATAACGCCTGAAGCGCGGGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACCGGACAAGTGGCAGATACAGCTACCGTCCGCCTTTGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCACACCGCGCCGGTTTTTCCGTTTGAGCCAAACTGGGGTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CCCGTCGCTGGTCAAGGAGCGGGTCAAGGGGCGTCC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ACGGCGTGCACTGGGTACTTTGCTTTCCCGTCGAA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ACCGGGTCTGACCCATATATTGCATCACGAGTGC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TGTTCTCAACCGAAATCACCGTATCCGACGGGTTG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ACGGTTGGCTTCAACATGGCGTTTCAATCCTGGGTG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GACGCGGTGATTCGTGAGGCAATCAAAGACAGGATT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CACGCTGCCGTTGCTGCTGGCGGGCTGGACAAGCTG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GGCCGCTATCTGCACCTGCAGGGGAAGGTGTATTACGC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CGGTGTGCTATGCAGTGTGGGGCTGGCGTCCACG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TACGGGAGACGGCGCAGAAGCTCCCCTAAAGCGT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TCACACGCTTCTACGCGAATTCACAGACCGGGAATGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ACCGGCGAGAGACCGTTTCTATCCTGCCTTGGGATA
GTGCAAAAATCTTTGATGCCGAAAGGCATTGATCAC	ATTTCAGCCGAGCGACCGCCGCTTGGATTTGTTCACGA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCCATCGCAGTCAAGAGCACTCGCTCGCTCTCGCAACA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TTATCACAGCGCGCCTCGACCGCAAAGTTGACGCAAAG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CTGTCACACGTGCTGGGAGTACACACCAGAGGGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TGGTTTCTCCTTTCCCGCATAAAACGGCTTCGAGTG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CGATTGCGTCAGCGTCACGCACCTTGTCTTTGACAG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCGAACTCGTCTTGGTGCGTGTCGTTATCCGGGAGACA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TTGACCGGAGACTGCTGCGAACCAACCTTGTTGGCG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ATCTCTGGGTCGGATACGTCCGACCCAACACAGCCG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCAGTTGCACCGCCGCCGAGAAAACTTGCGGCTT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CACACCATAGTACTGCTTCCACGCAAGAGCGCGTCGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AGCAGGCTGTAGTGTTTTCCATCCAGTCTTGCGACTG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ATCGCCCCTAAGTCTGGCGGCTCCCAAGTGTCCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TAGACTTTTGCGAGTTTCAGCGACATAAGGCGGGTCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AATCGCTGCTCGCACGGGTGCTTTTACTGTTTCGC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CTTCAGTTAGAGGCCCTTCAAGACTTGCTCAATCAG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GGCCGCATCCTGTACTCGCCGTCAATGCCGGGCC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GACGGCGGCCAAGATCAGTCCGAAACACGCCGTCGG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCCCATGAGGTTTCGTTTCTTTTTTCGATCTGCGA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CTCCCTTTTTTTCTGCTTGTAGAGAAGGCGCCTA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TCAACGAAACCCGTAAAACCCTGAACGCCTACGCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	AGACGGGACTGACTACGGCTTACCCAGCCTGGTT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CTTGCCAAACTTCTACCGCTACTTCCAGCGCATAAG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCCAGCCGGTAAGAATCAAGCTGGTCTAGTTCTAAC
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TCCGACAAGCCAATTGGCGCGGTCAAACGCAGGTCA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	GCCGGGCGGGGGCTACGCCCGAAATCTCACACCG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	ATACCAAGTATAATAGACTTCTGTGCGAAGTTGTA
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TGCTGACGGTTGTGGACGACAGCGAGGATGATTCG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CACCCGTCACGCGGGTGCGAGTGCCGGAAGGCACTG
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	TTTGATTCGGTCTCAATCGAGCACGAACGCGCGTTT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC	CGGCCGAAATACCGGCCATATTTCCGCGCTGGCTT
GTGCAAAAATCTTTGATGCCGAAAGGCGTTGATCAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_016025.1\|WP_014101080.1\|410163_411129_-\|anthranilate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234682
NC_016025.1\|WP_014101086.1\|417935_418610_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	cas5	cd09688_cas5_CAS-I-B	gnl\|CDD\|187819
NC_016025.1\|WP_014101081.1\|411312_412299_+\|WYL-domain-containing-protein	WYL	pfam13280_WYL_CAS-I:CAS-III	gnl\|CDD\|379100
NC_016025.1\|WP_014101093.1\|433730_434027_+\|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272
NC_016025.1\|WP_014101092.1\|432447_433710_+\|transposase	Cas14c_CAS-V-F	-	gnl\|CDD\|223747
NC_016025.1\|WP_041569980.1\|433945_434365_+\|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272
NC_016025.1\|WP_148264148.1\|408899_410021_-\|ferritin-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|153097
NC_016025.1\|WP_014101098.1\|437828_439580_+\|right-handed-parallel-beta-helix-repeat-containing-protein	unknown	unknown	gnl\|CDD\|270916
NC_016025.1\|WP_014101083.1\|412966_415450_+\|CRISPR-associated-helicase-Cas3'	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|273707
NC_016025.1\|WP_014101084.1\|415407_416979_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	cas8b3	cd09713_cas8b3_CAS-I-B	gnl\|CDD\|132524
NC_016025.1\|WP_014101091.1\|430663_432451_+\|two-component-regulator	unknown	unknown	gnl\|CDD\|225829
NC_016025.1\|WP_014101089.1\|428382_429168_+\|two-component-regulator	unknown	unknown	gnl\|CDD\|225829
NC_016025.1\|WP_014101085.1\|416975_417929_+\|DevR-family-CRISPR-associated-autoregulator	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|274215
NC_016025.1\|WP_014101097.1\|437186_437813_+\|nucleotidyltransferase-family-protein	unknown	unknown	gnl\|CDD\|133025
NC_016025.1\|WP_014101090.1\|429164_430427_-\|transposase	Cas14c_CAS-V-F	-	gnl\|CDD\|223747
NC_016025.1\|WP_014101088.1\|420396_420687_+\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NC_016025.1\|WP_014101096.1\|436035_437190_+\|XdhC-family-protein	unknown	unknown	gnl\|CDD\|379212
NC_016025.1\|WP_041570147.1\|418678_420370_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|274899
NC_016025.1\|WP_014101082.1\|412370_412970_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|370559
NC_016025.1\|WP_014101095.1\|434633_435839_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237057

Protein	Function_ID	Function_description	E-value
NC_016025.1\|WP_014101080.1\|410163_411129_-\|anthranilate-phosphoribosyltransferase	gnl\|CDD\|234682	PRK00188, trpD, anthranilate phosphoribosyltransferase; Provisional.	6.89634e-84
NC_016025.1\|WP_014101086.1\|417935_418610_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	gnl\|CDD\|187819	cd09688, Cas5_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex; in subtype I-C this protein might be the endoribonuclease that generates crRNAs; also known as DevS family.	2.44608e-49
NC_016025.1\|WP_014101081.1\|411312_412299_+\|WYL-domain-containing-protein	gnl\|CDD\|379100	pfam13280, WYL, WYL domain. WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the WYL-like superfamily, named for three conserved amino acids found in a subset of the superfamily. However, these residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by a cysteine, which are predicted to line a ligand-binding groove typical of the Sm-like SH3 beta-barrels. A WYL domain protein (sll7009) is a negative regulator of the I-D CRISPR-Cas system in Synechocystis sp. It is predicted to be a ligand-sensing domain that could bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas and other defense systems such as the abortive infection AbiG system.	6.16549e-43
NC_016025.1\|WP_014101093.1\|433730_434027_+\|SpoIIE-family-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	2.96588e-07
NC_016025.1\|WP_014101092.1\|432447_433710_+\|transposase	gnl\|CDD\|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	5.72906e-50
NC_016025.1\|WP_041569980.1\|433945_434365_+\|SpoIIE-family-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	6.25457e-12
NC_016025.1\|WP_148264148.1\|408899_410021_-\|ferritin-like-domain-containing-protein	gnl\|CDD\|153097	cd00657, Ferritin_like, Ferritin-like superfamily of diiron-containing four-helix-bundle proteins. Ferritin-like, diiron-carboxylate proteins participate in a range of functions including iron regulation, mono-oxygenation, and reactive radical production. These proteins are characterized by the fact that they catalyze dioxygen-dependent oxidation-hydroxylation reactions within diiron centers; one exception is manganese catalase, which catalyzes peroxide-dependent oxidation-reduction within a dimanganese center. Diiron-carboxylate proteins are further characterized by the presence of duplicate metal ligands, glutamates and histidines (ExxH) and two additional glutamates within a four-helix bundle. Outside of these conserved residues there is little obvious homology. Members include bacterioferritin, ferritin, rubrerythrin, aromatic and alkene monooxygenase hydroxylases (AAMH), ribonucleotide reductase R2 (RNRR2), acyl-ACP-desaturases (Acyl_ACP_Desat), manganese (Mn) catalases, demethoxyubiquinone hydroxylases (DMQH), DNA protecting proteins (DPS), and ubiquinol oxidases (AOX), and the aerobic cyclase system, Fe-containing subunit (ACSF).	8.70101e-14
NC_016025.1\|WP_014101098.1\|437828_439580_+\|right-handed-parallel-beta-helix-repeat-containing-protein	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.44805e-30
NC_016025.1\|WP_014101083.1\|412966_415450_+\|CRISPR-associated-helicase-Cas3'	gnl\|CDD\|273707	TIGR01587, CRISPR-associated_endonuclease/helicase_Cas3, CRISPR-associated helicase Cas3. This model represents the highly conserved core region of an alignment of Cas3, a protein found in association with CRISPR repeat elements in a broad range of bacteria and archaea. Cas3 appears to be a helicase, with regions found by pfam00270 (DEAD/DEAH box helicase) and pfam00271 (Helicase conserved C-terminal domain). Some but not all members have an N-terminal HD domain region (pfam01966) that is not included within this model.	3.549e-41
NC_016025.1\|WP_014101084.1\|415407_416979_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	gnl\|CDD\|132524	TIGR03485, hypothetical_protein_L8106_30105, CRISPR-associated protein Cas8a1/Csx13, MYXAN subtype. Members of this family are found among cas (CRISPR-Associated) genes close to CRISPR repeats in Leptospira interrogans (a spirochete), Myxococcus xanthus (a delta-proteobacterium), and Lyngbya sp. PCC 8106 (a cyanobacterium). It is found with other cas genes in Anabaena variabilis ATCC 29413. In Lyngbya sp., the protein is split into two tandem genes. This model corresponds to the N-terminal region or upstream gene; the C-terminal region is described by TIGR03486. CRISPR/cas systems are associated with prokaryotic acquired resistance to phage and other exogenous DNA.	4.9527e-33
NC_016025.1\|WP_014101091.1\|430663_432451_+\|two-component-regulator	gnl\|CDD\|225829	COG3292, COG3292, Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms].	6.02215e-16
NC_016025.1\|WP_014101089.1\|428382_429168_+\|two-component-regulator	gnl\|CDD\|225829	COG3292, COG3292, Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms].	4.11099e-20
NC_016025.1\|WP_014101085.1\|416975_417929_+\|DevR-family-CRISPR-associated-autoregulator	gnl\|CDD\|274215	TIGR02585, conserved_protein, CRISPR-associated protein Cas7/Cst2/DevR, subtype I-B/TNEAP. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This clade is a member of the DevR family (TIGR01875) and includes the DevR protein of Myxococcus xanthus, a protein whose expression appears to be regulated through a number of means, including both location and autorepression; DevR mutants are incapable of fruiting body development.	1.39193e-25
NC_016025.1\|WP_014101097.1\|437186_437813_+\|nucleotidyltransferase-family-protein	gnl\|CDD\|133025	cd04182, GT_2_like_f, GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.	1.35977e-51
NC_016025.1\|WP_014101090.1\|429164_430427_-\|transposase	gnl\|CDD\|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	2.53121e-50
NC_016025.1\|WP_014101088.1\|420396_420687_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	1.07597e-12
NC_016025.1\|WP_014101096.1\|436035_437190_+\|XdhC-family-protein	gnl\|CDD\|379212	pfam13478, XdhC_C, XdhC Rossmann domain. This entry is the rossmann domain found in the Xanthine dehydrogenase accessory protein.	2.39907e-47
NC_016025.1\|WP_041570147.1\|418678_420370_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	gnl\|CDD\|274899	TIGR03983, hypothetical_protein_LA3181, CRISPR-associated endonuclease Cas1, subtype MYXAN. Members of this protein are the Cas1 endonuclease, or Cas1 domain in Cas4/Cas1 fusion proteins, of the MYXAN subtype of CRISPR/Cas systems. These systems typically feature repeats and spacers each about 36 base pairs in length. Species with this type of CRISPR system include Myxococcus xanthus, Cyanothece sp., Leptospira interrogans, Sorangium cellulosum, Anabaena variabilis ATCC 29413, etc.	7.84925e-159
NC_016025.1\|WP_014101082.1\|412370_412970_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	gnl\|CDD\|370559	pfam09559, Cas6, Cas6 Crispr. The Cas6 Crispr family of proteins averaging 140 residues are characterized by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus. The CRISPR-Cas system is possibly a mechanism of defense against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	3.32899e-83
NC_016025.1\|WP_014101095.1\|434633_435839_-\|hypothetical-protein	gnl\|CDD\|237057	PRK12323, PRK12323, DNA polymerase III subunit gamma/tau.	1.77024e-08

>NC_016025.1|WP_014101088.1|420396_420687_+|CRISPR-associated-endonuclease-Cas2
MGERRWYLVSYDVRDPKRWRKVYERVKGNAERVQFSVFRMYCTKTDLEQLRFDLAKLMTSEDDLLVIHLCPGCARRVVDTSTKTSWDEERKRIEIL
>NC_016025.1|WP_041570147.1|418678_420370_+|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1
MGTPDDVVPLTRVMALHALAYCERLFYLEEVEEIRLANDRVYEGRRVHLQDISEGIETLTYEMESERWGIRGKVDAVRYRDGSLVAYEHKKGKSNRRAAWPSDRLQVIAYCALLEEATGKTILEGRIRYHADNVTVRVPFDDAARQELRAAVARAAELRQHIERPPVTSDVRLCRHCALAPVCLPEEDRLAVITADAPESEAEPADAKVRRLFPERDERRILHITEPGTRVERAAEELVVEIPGRVPVRFPGRDVGAVVLHGAVQITTQAIHYCAANDVAIHWLTGGGNVVGSFRGGTPGVQRRHRQYAALSDPDFCLALARRLAMAKVENQIRYILRATRPMLTEAGRDPALEQHLTQMRHALAQISRAVGPDEIRGYEGSAGQAYFAAFASLIRTSPSEPGSPAGFEFVGRNRRPPRDRVNALLSFFYALVYKDCLAALIAVGLEPSFGFLHTPRSAAHPLALDLMELFRVPLADMPVVASINRKQWDATEDFVVTPHKVWLSLEGKRKAIALYEERKQESWQHPVLRYSLSYQRAIELEARLLEKEWTGAPGLFARMRLR
>NC_016025.1|WP_014101086.1|417935_418610_+|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS
MLTLHVEVPYGSFRKSYARSLAETYPLPPPATVYGMLLSLVGEGFRRRHVGVRLALAFSGTYGNGSQRHSPFPRVAQTLRKLSRYKYGEAPKQSEQGNRPDYIETLCDIAFLCWVDSAQETNPEPRLEMRLREALETPEKITRYGVLSLGLSDDAVNDICLVQKPTGDWHRLKPSQEGSLELPVWVDHVGSRHTRWQRYELEREPVTPTEPPLEAYWTVIRPPA
>NC_016025.1|WP_014101085.1|416975_417929_+|DevR-family-CRISPR-associated-autoregulator
MTTHYLYATILTGEAVAANNRGDNLGNTTTLQKVFHQDDVHTSISAEAIRFALRYRFQLAGLPVNRRYDGDRLIYADEKRTYWGSRTPFIDDDLMGFMDAAAAQAERDDEEAEPGSTAKSGKKKKGTVTKRTSPLAVGRAVSLRPYRGELSFNCVSGVKEKGKLSLYNAEMHTTEYQYSIALNLNDVLDKQNIGHLIDALIEPPPVAGNHARFYYDFSPASIIFRVTSAHASRIQNCFEHDEEGRTYTVARLIRRVASGDIPAEELIIGGELSHTDEGKKLKELGVTVLDGVRKAADEARRRIARRDKAFAVLAEGR
>NC_016025.1|WP_014101084.1|415407_416979_+|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1
MGQRTTGYQLPNPLVYELGNPNFTVYHRAALGGLAATIEAWKKNPRLKPEGIAAEVDAGKVEIRWDKKLSDRQFIRRLLEASFRLTPDKLIDLPGHGIETDRDGLRLAIHTGLCGTFLQHNKMRPGEKTPRTLKVQVEGEEQEYLLTYKAVNSYAHQKAQGTRLLGGDDQAPLPPVALIPQSVVPGAMTGASELEGPPEEVLLLLYLMVGSAVFLLRSYRHESRAQYCLVIPDVKNLKSFARNLRQIAARGANFLTNGYPGRIAGGTEEAALRFLLALEAGNLTEEFGRSVSGCLAVAMGKAPWDRKQNYRTLVVRLGAEYPELEVFRAALQHFGKGRLLTSARGEAFPASPNPLPELIAANLAAERHWCADFIQRCQEKKDFEQLTFQKGGLAAMTKAIKDEDDQAIIAIFHEAWRMTMGALSERAQREGSDFTALVERERERTRNAILRAKTAEALAGWFLRFCADATKGAALAGMKRNAARVREFIFNPRNFERFQNLLLFALVSYMGREDNLSEGGIDA
>NC_016025.1|WP_014101083.1|412966_415450_+|CRISPR-associated-helicase-Cas3'
MSTALPKYLLAKSYPQTKFPQQPPDYALLLQHNRDVAQACTALVEVIGRLVLERAGLTETDIEAFKKAMAAVGWFEDLGKANSHFQAMVTKAPQLIQLLRHETLSGLLLWQNKALRECLEPALGEWFIPALWAAMGHHRKFDCDTQASEAPALTVWLNHPDFRQMLVELGERLELKTAPPAFSEPLIVAPDNRNRDNRNPNAVSARRALQDLKEDFDDLREQLAPEWSKRLAVMKALGIAADVAASAIAARGQSAASYSLDTFVRETLGHVGLDAADFDRLIGEWAWKATGQPRPSDAPQLPPGFAFRPFQCEVAASERFVTLACAGCGSGKSLAAYLWAQAWQRRTGQTNFRLFFCLPTTGTTTEHFKDYALEAGLSAALTHSRSTVDLKALAETADQESDVDASNAERAAQRALDDLRDKIEALSLWDTPLVVTTADTVLGLMANARRPLYAFPAIALSAIVFDEIHAFDDRLFGHLLAFLQFFPKQPVLLMTASLPQHRLAALQKVRPDLRVIAGPPAYEQLPRYKLRYPSSPEEVWQAVADCIAQGGKVLWVRNRVEWANETYAACRERFPKVEVNVYHSRFRYRDRSKLHHYVIGKFKGRDAQILVTTQVAEMSLDLSADLLITDIASVPALIQRMGRANRRSTPECPQPPKPVLVCPLPPKADERDNPALPYDAEDITAAELWIERLLSLEKPLSQRDLADAFGSLSPGKDFDVEQAWKAACFVSGGWETRPGMTRGEGYTVNVILEADWKAYGQSEPGRDWLIEHEVAIPFRPEVLRWGTVGSRRLAPAERVAYDFNPETKKGTGARWVSAQPATNCQIL
>NC_016025.1|WP_014101082.1|412370_412970_+|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6
MTDSPIVEMRFYLSGERLPVDHGYLLYAALSHLLPWLHDDTAVRLAPIRGLYASGNNLLLQNWSRLVIRTPADRLAGFLALAGRTLDVGGCRLRLGVPSIHTLRPASTLYAHLVTTRNGQDEARFDVEIARQLAVLGINGQVARGARRTFTVHGRHLVGYALSISGLDPEASVTLQAAGLGGRRKMGCGFFVPRKEGQP
>NC_016025.1|WP_014101081.1|411312_412299_+|WYL-domain-containing-protein
MNSTQRTHLRQLERLTWIHREIQAGRFPNTRRIAEHFGVSRKTAQETIDFMRDRFQLPLEYCAQQRGFHYTEPVHSLPWMTLTEGEIAAILMAERLAQAYGGQAAAGITEALTKVIQTLTETVSVDLNHLMALQSVEALPTSPIDQAHFALFAKAIAHRHPVRMVYFTQSSGETKTRTVNPLRLHSAKAEWYVIAFDHLRQKVLDFHLGRVRAAELLDDTFEPPTGFDIETYLNRGFGMIRGEDQTYEVIVEFDAYQARWIRQQSKVHKTAHYTDLPDGGLRVTMQVGALEGVRQWVLQYGARVRVIAPEQLRTMLRTEAEALLKLYA
>NC_016025.1|WP_014101080.1|410163_411129_-|anthranilate-phosphoribosyltransferase
MMDETLANHLAALLAGRLSEAETDALLASLTPDTATFEQFTTLIAAVRATACPLPELAEPVFDCCGTGGSGRPHFNVSTTVAFVLAAGGVRVVKFGNRAATSTSGSFDLLEQLGVPVEYPPERLPRLLDATNLAFLYAPQCYPALKAVAAARRRFGRPTLFNYIGPLLHPLHPGRRVMGVSHPRMQAFIAQWLATDPRTHRAVVVRGHENRDELTPVGTSVLYEVTPRRIDKRSWTPLDLPCDVEAQPYTPEANLRQFQDIVTGRDTVSADYHSVRLNAGLGFVAAGRTETLADGAACAAELLASGEVQRQVETFLAHVHR
>NC_016025.1|WP_148264148.1|408899_410021_-|ferritin-like-domain-containing-protein
MQQGALLYQATANGNVRVLAGLLGPAYRGLIQKRGKREDTTALPVGYPANFDWRYERNQPEIRRLTEAAKTAQWNATTDLDWQRLVDPFHPDTVLLPEKFHPAYWLPLWSKLTEHERRVQLHALTSWLLSQFLHGEQGALYAAALTTTAVPWLDAKLYGGTQVMDESRHVEAFHTYLTTKLEKLYDINDNLYVVIDALMTDSRWDVKFLGMQIMIEGLALGAFTTLRQLSGEPLLRDLLKMVITDEARHVHFGVLALGEFYLREVSERERRDREDWAFEMAVLLRNRFLLHEIYDEHFAHRLRRAQWNRLVLHSDMMAMFRRTMFRRIIPNLKRIGLLSDRIRPHYAQLGLLAFEHERPATELTAADLLEDTV
>NC_016025.1|WP_014101089.1|428382_429168_+|two-component-regulator
MPRWLFCLIILLCNTPGAYALDPNKVLTQYVRQVWLASDGLPLNAIFTITQTRDGYIWVGTHEGLARFDGIHFTTFNRQNTPILNNNRITVLCEAPSGALWIGTGGDRFFSSGGVRGGGLFRYDQGRWQRFGMDDGLPDDIINALTIDPPGTLWAGTMNGLVAFDGQRFTHYTAGLPSTKIAALRFDRQGILWIGTTSGLARFQQGRIETTELTDHSIQALYEDQAGCLWIGTQTGLLYRPPSSTRCIPTKVTSPLTYSPA
>NC_016025.1|WP_014101090.1|429164_430427_-|transposase
MRVMEAKLLNGTAEQYQALDEAIRTAQFVRNKCVRYWMDNKSVNKAVLYAYCQDLAKEFDFARKLNSAARQASAERAWASISRFYTNCRNKAVRKGYPKFKKHCRSVEYKVSGWKLSGDGMSIIFTDGFNAGAFALYCNGEARHHILNSKINRVRVIRRADGYYAQFCLDVERKEQGAYTGNVIGIDLGLKAFYTDQNGNPVEYPKFLRRSERRLKQHQRRLSRKFKKGAKSQSRNYHKQRKRLGKVHLKVQRQRKDWAIKQARCVVASHDVVAYEDLQVKNLVKNHHLAKSIHDAGWSQFTAWLDYYGKVWDKAVVSVPPQYTTQDCSNCGHRVVKTLSTRTHSCPQCGFESDRDQNAALNILKKGLSILGMEWQNSTFGQKGTASKEGTLGERCTAALEGQPDEVSALAEPRTRIPCL
>NC_016025.1|WP_014101091.1|430663_432451_+|two-component-regulator
MSLCLLTGREGELWVGTGRGLYCFHDGAVTPLGEPEGLLGTYTYPILQDRAGVIWVGTSEGGLSRIEQGKVTATWGQRPGKSGRPGLPGDDVLALCEDHTGALWLGSSTGLTRKEGNRFTTYRPANGLSGLPVRVIHEEPDGSLLIGAGTTLCRFAGGKFTRMGTNEGYPVPDAQVLFIGRDRDGNLWIGTNRGLVCQRQGRFTLYGVADGLPNPNVKYLYHDSQGILWFGTAGGLVHFANHRFTAITTRQGLFDDNIHVILVDDQDRFWMSSNLGIFTVPRAELTACAEKRQPRVTCRVFGPSDGMRDQEGNGSRQPAGCRAADGSLWFPTTNGIAILNPVTLPYNASPPPVTIERLLADGQSLENLSPVLPVHTQTVEIHYTGLSFILPKQVTFAYQLSGLSQDWQAAGSRRTAYFSGLPPGTYTFRVRAFNRDGVASANVAEVRFSIPAPWYRTRLAYAGYLLLALSLIAEGVRWRLAALRRLALRLEQTVAARTAEIYQQQEALRGQRDEIERKNAEMLESIRYAERIQRALLPRAGQLTTTLTDAFVVYLPRDIVSGDFYRKNAVKPCTLGQGYKAHAVLSSQTCDKIAV
>NC_016025.1|WP_014101092.1|432447_433710_+|transposase
MRVMEAKLLNGTVEQYQALDEAIRTAQFVRNKCVRYWMDNKSVNKAVLYAHCKDLAKEFDFVRKLNSAARQASAERAWASISRFHTNCRNKAVKKGYPKFKKHCRSVEYKVSGWKLSGDGMSITFTDGFNAGAFALYCNGEARHHILNSKINRVRVIRRADGYYAQFCLDVERKERGEYTGNVIGIDLGLKAFYTDQNGNPVEYPKFLRRSERKLKQHQRRLSRKFKKGAKSQSKNYHKQRKRLGKVHLKVQRQRKDWAIKQARCVVASHDVVAYEDLQVKNLVKNHHLAKSIHDAGWSQFTAWLDYYGKVWDKAVVSVPPQYTTQDCSHCGHRVVKTLSTRTHSCPQCGFELDRDQNAALNILKKGLSILGMEWQNSTFGQKGTASKEGTLGERCTAALEGQPDEVSALAEPRTRIPCL
>NC_016025.1|WP_014101093.1|433730_434027_+|SpoIIE-family-protein-phosphatase
MRNLDADTVLLAVGDCTGHGVPGALMSMIGITLLDRLIQEGVTEPALILEQLHLGIRRALQQDGDTKTARTAWTSDCAASNARLAGSAFPARPFALTS
>NC_016025.1|WP_041569980.1|433945_434365_+|SpoIIE-family-protein-phosphatase
MDIGLCRIERATGRLCFSGAALRAYLVTPAGELTTIKGDTKSIGGRQREAYRTFTHHEVDYADGTMLYLLTDGFTDQKNPTGERYGSRRTGQKLQQIASLPAARQAEALSREIHLFRGTEAQLDDIAIVGVRLKVKHGE
>NC_016025.1|WP_014101095.1|434633_435839_-|hypothetical-protein
MSSASEELDNPLYGDFEDYLDGKLPPARHREVADLLARSAAARERLEELRTARKWLEGTHWDVPEPSGWPSAGEILARAGWRPAASLPAAKPDRSTGRFAGWLSGWMPWQWNVRSPVWALGAAAGVFLLVGGGLWWWVLSPSAPDELAQSKVSENSEPLARPELAPARPEDAARPALPAEATPAGAAPRKKDPAASASEAASPEGKSKRSGPSAGSARVAEDSQRAEVASAPSPLAAPAGPPAGRVPAAPVPSAGDETAHKAEAMSAERREARPLAAAPPLEAGAPPPVAGRASGTGTADSARDETKEAPKAKPGSAANAQGAAAPVTALTLRLVVANRRAALTQVATVVREFGGSVRLDGEQVVVTVPAGQVSACAARLRVRVAVVTEGETLQVTIRERE
>NC_016025.1|WP_014101096.1|436035_437190_+|XdhC-family-protein
MSELDVLLMALRRFTSPAPCHLALATVVSVTGSFYRRPGARMLIAETGETVGNISGGCLEPDLIERAQAILASGKAQLVSYDLHDVATDTTWGPALGCEGETLIYIEPFHANQSHHPLDLLALTRATGEDAALAHVFQAEGEFAGRAGFRLLHTADTPEANGAPIEQAGWIRQLHFELRTCLSERRSRQMTYTTARGSLRAFVEFLPAPLQLTILGAGDDALPLAQLADRLGWHVTVADWRPALATPERFPTARQVLVVPTVNDLPLRAQDHVVVMTHHYPSDKAIVRRLAAVQPRYVGLLGPRRRTERMLAELADEGCRVAPEIVEAWHFPVGLDLGAETPVEVAVSIVAEILAVANRRNGQFLRQREAPIHTPLPVSSSLSP
>NC_016025.1|WP_014101097.1|437186_437813_+|nucleotidyltransferase-family-protein
MSVAPGRFPSAAILLAGGAARRMGGRPKLLLSIDGESLLQRAIRLARAVQAAPILVVLGGHAESYRAHLADADSGPDVQLIDNPQWAEGLGASLRCGVAALPPNRPPEATFFVLAPDQPLVSVTQLHRLQDALRDHPEATAAACDYAGTPGVPVLFRYVWRHRLLEAHGDIGARRYLQEYRHEVTTLPFPEGACDIDTDEDYAAFLRR
>NC_016025.1|WP_014101098.1|437828_439580_+|right-handed-parallel-beta-helix-repeat-containing-protein
MPHPAANVPPLRPGLVIGEYRLDASLTADVGDAAWRGQSLLDQAIVRLDVFQDTPATSPLTRVAFELAKLPPHPNLLPVLDVVTMDALTFVVSPYLPTSLAERPRPLTPEAAVHTIRQLLEALQVLHEHGQVHGRLAPDYVALDGEHVRLRGYGFSQVRPRPAEILPYVSPHALDAPPTPQDDIWAAGVLLFELLSGDLPFPHQNQDDLLLAIRTLYPDPLPHTLPARLRHIVARALERDRRRQYATAQQMAEELTACAAELAQETTARTSSPSLRPFAVASIASPPGRHTGRLALLVIGLISFLMLAGIWLTVRYFEGKDMWRMLPNETIVAPAGGDFATISEAIRSARTGARILIRPGVYRETVLLTKNIELVADGPAGSVIIASHDAPCLRQSLGAQVVRGLTLQSHQAPAIQLNGGALTIEDSQMTAVAGEGVAVKGTETRLVMRRSRLHDGPGHGLAATDGARLELVECDIIGHGGDGIRLTGQAQLRAYDSRIADNRQAGVRALERAAARLERCTLERNGKATDGNVTLGQLPGAQASKPALKEGLPARSQHCASHVFPANWRHSTPHTGLTHHGPE

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Crispr_ID: NC_016025_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016025_3

464322-464806

Orphan

Consensus_repeat	Method
AATTCAAGGGGTCTTTTTCAAGACCCATGAC	PILER-CR
AATTCAAGGGGTCTTTTTCAAGACCCATGACG	CRISPRCasFinder
AATTCAAGGGGTCTTTTTCAAGACCCATGAC	CRT

6 spacers

The CRISPR arrays of NC_016025_3

>merge|NC_016025|3|464322-464806|PILER-CR,CRISPRCasFinder,CRT
AATTCAAGGGGTCTTTTTCAAGACCCATGACGCGTTGGTCAGGGCACGCAGCGTGCCGCGCTTGAACTCGTCCTTTAATTCAAGGGGTCTTTTTCAAGACCCATGACCAGAGGGAGCGGAGAAGGCCAACCGTGAACGGAGTTCCTTTAATTCAAGGGGTCTTTTTCAAGACCCATGACGGGCACAGCCGCTAAAATCCTGTCTCTGATGGCCTCTCCCTTTAATTCAATTCAAGGGGTCTTTTTCAAGACCCATGACGTAATTCGTTTCTACACTATTCTATACGCCCTGTCAAGTAACCTTTAATTCAAGGGGTCTTTTTCAAGACCCATGACGATGCGGATACAGTTTCAGATAACCAACCACCGACTGCCTTTAATTCAAGGGGTCTTTTTCAAGACCCATGACCGGGCTGTCAAGGTAAATGAAGTCGCTGAATGTCCACTTTAATTCAATTCAAGGGGTCTTTTTCAAGACCCATGACT

>NC_016025|3|3|464322-464805|PILER-CR
AATTCAAGGGGTCTTTTTCAAGACCCATGAC	GCGTTGGTCAGGGCACGCAGCGTGCCGCGCTTGAACTCGTCCTTT
AATTCAAGGGGTCTTTTTCAAGACCCATGAC	CAGAGGGAGCGGAGAAGGCCAACCGTGAACGGAGTTCCTTT
AATTCAAGGGGTCTTTTTCAAGACCCATGAC	GGGCACAGCCGCTAAAATCCTGTCTCTGATGGCCTCTCCCTTTAATTC
AATTCAAGGGGTCTTTTTCAAGACCCATGAC	GTAATTCGTTTCTACACTATTCTATACGCCCTGTCAAGTAACCTTT
AATTCAAGGGGTCTTTTTCAAGACCCATGAC	GATGCGGATACAGTTTCAGATAACCAACCACCGACTGCCTTT
AATTCAAGGGGTCTTTTTCAAGACCCATGAC	CGGGCTGTCAAGGTAAATGAAGTCGCTGAATGTCCACTTTAATTC
AATTCAAGGGGTCTTTTTCAAGACCCATGAC

>NC_016025|3|3|464322-464806|CRISPRCasFinder
AATTCAAGGGGTCTTTTTCAAGACCCATGACG	CGTTGGTCAGGGCACGCAGCGTGCCGCGCTTGAACTCGTCCTTT
AATTCAAGGGGTCTTTTTCAAGACCCATGACC	AGAGGGAGCGGAGAAGGCCAACCGTGAACGGAGTTCCTTT
AATTCAAGGGGTCTTTTTCAAGACCCATGACG	GGCACAGCCGCTAAAATCCTGTCTCTGATGGCCTCTCCCTTTAATTC
AATTCAAGGGGTCTTTTTCAAGACCCATGACG	TAATTCGTTTCTACACTATTCTATACGCCCTGTCAAGTAACCTTT
AATTCAAGGGGTCTTTTTCAAGACCCATGACG	ATGCGGATACAGTTTCAGATAACCAACCACCGACTGCCTTT
AATTCAAGGGGTCTTTTTCAAGACCCATGACC	GGGCTGTCAAGGTAAATGAAGTCGCTGAATGTCCACTTTAATTC
AATTCAAGGGGTCTTTTTCAAGACCCATGACT

>NC_016025|3|2|464322-464805|CRT
AATTCAAGGGGTCTTTTTCAAGACCCATGAC	GCGTTGGTCAGGGCACGCAGCGTGCCGCGCTTGAACTCGTCCTTT
AATTCAAGGGGTCTTTTTCAAGACCCATGAC	CAGAGGGAGCGGAGAAGGCCAACCGTGAACGGAGTTCCTTT
AATTCAAGGGGTCTTTTTCAAGACCCATGAC	GGGCACAGCCGCTAAAATCCTGTCTCTGATGGCCTCTCCCTTTAATTC
AATTCAAGGGGTCTTTTTCAAGACCCATGAC	GTAATTCGTTTCTACACTATTCTATACGCCCTGTCAAGTAACCTTT
AATTCAAGGGGTCTTTTTCAAGACCCATGAC	GATGCGGATACAGTTTCAGATAACCAACCACCGACTGCCTTT
AATTCAAGGGGTCTTTTTCAAGACCCATGAC	CGGGCTGTCAAGGTAAATGAAGTCGCTGAATGTCCACTTTAATTC
AATTCAAGGGGTCTTTTTCAAGACCCATGAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_016025.1\|WP_014101114.1\|459580_460279_+\|leucyl/phenylalanyl-tRNA--protein-transferase	unknown	unknown	gnl\|CDD\|234720
NC_016025.1\|WP_014101124.1\|473409_474639_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340883
NC_016025.1\|WP_014101123.1\|472867_473413_+\|DinB-family-protein	unknown	unknown	gnl\|CDD\|378981
NC_016025.1\|WP_014101130.1\|478285_479302_+\|isocitrate-dehydrogenase-(NAD(+))	unknown	unknown	gnl\|CDD\|223549
NC_016025.1\|WP_014101128.1\|477223_477640_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227645
NC_016025.1\|WP_014101126.1\|475499_476138_-\|hypothetical-protein	unknown	unknown	unknown
NC_016025.1\|WP_014101125.1\|474694_475486_-\|hypothetical-protein	unknown	unknown	unknown
NC_016025.1\|WP_014101108.1\|452424_454254_+\|hypothetical-protein	unknown	unknown	unknown
NC_016025.1\|WP_014101111.1\|456312_457596_-\|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|224331
NC_016025.1\|WP_014101107.1\|449276_452390_-\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223911
NC_016025.1\|WP_041569985.1\|460480_462709_+\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|274577
NC_016025.1\|WP_014101113.1\|457945_459202_+\|formylglycine-generating-enzyme-family-protein	unknown	unknown	gnl\|CDD\|224182
NC_016025.1\|WP_014101117.1\|462832_463759_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|214915
NC_016025.1\|WP_014101106.1\|447859_449266_-\|TolC-family-protein	unknown	unknown	gnl\|CDD\|224455
NC_016025.1\|WP_049787537.1\|470677_472564_-\|hypothetical-protein	unknown	unknown	unknown
NC_016025.1\|WP_014101109.1\|454257_455592_-\|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|273776
NC_016025.1\|WP_187288474.1\|455593_456256_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380063
NC_016025.1\|WP_014101129.1\|477689_478289_+\|Uma2-family-endonuclease	unknown	unknown	gnl\|CDD\|99749
NC_016025.1\|WP_014101127.1\|476527_477208_+\|VTT-domain-containing-protein	unknown	unknown	gnl\|CDD\|223659
NC_016025.1\|WP_148264149.1\|466399_469924_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|293789

Protein	Function_ID	Function_description	E-value
NC_016025.1\|WP_014101114.1\|459580_460279_+\|leucyl/phenylalanyl-tRNA--protein-transferase	gnl\|CDD\|234720	PRK00301, aat, leucyl/phenylalanyl-tRNA--protein transferase; Reviewed.	4.04351e-103
NC_016025.1\|WP_014101124.1\|473409_474639_+\|MFS-transporter	gnl\|CDD\|340883	cd17325, MFS_MdtG_SLC18_like, bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters. This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	5.59399e-16
NC_016025.1\|WP_014101128.1\|477223_477640_+\|hypothetical-protein	gnl\|CDD\|227645	COG5340, COG5340, Predicted transcriptional regulator [Transcription].	0.0063792
NC_016025.1\|WP_014101130.1\|478285_479302_+\|isocitrate-dehydrogenase-(NAD(+))	gnl\|CDD\|223549	COG0473, LeuB, Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism].	1.07351e-169
NC_016025.1\|WP_014101111.1\|456312_457596_-\|HEAT-repeat-domain-containing-protein	gnl\|CDD\|224331	COG1413, COG1413, FOG: HEAT repeat [Energy production and conversion].	3.18525e-14
NC_016025.1\|WP_014101123.1\|472867_473413_+\|DinB-family-protein	gnl\|CDD\|378981	pfam12867, DinB_2, DinB superfamily. The DinB family are an uncharacterized family of potential enzymes. The structure of these proteins is composed of a four helix bundle.	2.41029e-05
NC_016025.1\|WP_014101107.1\|449276_452390_-\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|223911	COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms].	0
NC_016025.1\|WP_041569985.1\|460480_462709_+\|VWA-domain-containing-protein	gnl\|CDD\|274577	TIGR03436, acidobact_VWFA, VWFA-related Acidobacterial domain. Members of this family are bacterial domains that include a region related to the von Willebrand factor type A (VWFA) domain (pfam00092). These domains are restricted to, and have undergone a large paralogous family expansion in, the Acidobacteria, including Solibacter usitatus and Acidobacterium capsulatum ATCC 51196.	1.22603e-54
NC_016025.1\|WP_014101113.1\|457945_459202_+\|formylglycine-generating-enzyme-family-protein	gnl\|CDD\|224182	COG1262, COG1262, Uncharacterized conserved protein [Function unknown].	1.02851e-62
NC_016025.1\|WP_014101117.1\|462832_463759_+\|hypothetical-protein	gnl\|CDD\|214915	smart00924, MgtE_N, MgtE intracellular N domain. This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. It is presumed to be an intracellular domain, that may be involved in magnesium binding.	0.000598934
NC_016025.1\|WP_148264149.1\|466399_469924_-\|hypothetical-protein	gnl\|CDD\|293789	sd00042, LVIVD, LVIVD repeat. LVIVD repeats are mainly found in bacterial and archaeal cell surface proteins, many of them hypothetical. Structurally, LVIVD repeats have been predicted to form a beta-propeller, with each repeat forming one four-stranded anti-parallel beta-sheet blade.	5.39932e-29
NC_016025.1\|WP_014101106.1\|447859_449266_-\|TolC-family-protein	gnl\|CDD\|224455	COG1538, TolC, Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion].	3.52056e-43
NC_016025.1\|WP_187288474.1\|455593_456256_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|380063	pfam17937, TetR_C_28, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in CgmR (C. glutamicum multidrug-responsive transcriptional repressor), previously called CGL2612 protein. CgmR (CGL2612) from Corynebacterium glutamicum is a multidrug-resistance-related transcription factor belonging to the TetR family. It regulates expression of the immediately upstream gene cgmA (cgl2611) by binding to the operator cgmO in the cgmA promoter. The cgmA gene encodes a permease belonging to the major facilitator superfamily, a protein family composed of bacterial multidrug exporters, and the pair of CgmR and CgmA confers multidrug resistance on C. glutamicum.	1.90052e-20
NC_016025.1\|WP_014101129.1\|477689_478289_+\|Uma2-family-endonuclease	gnl\|CDD\|99749	cd06260, DUF820, Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of nucleases.	6.47922e-39
NC_016025.1\|WP_014101127.1\|476527_477208_+\|VTT-domain-containing-protein	gnl\|CDD\|223659	COG0586, DedA, Uncharacterized membrane-associated protein [Function unknown].	1.961e-09
NC_016025.1\|WP_014101109.1\|454257_455592_-\|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|273776	TIGR01730, COG0845:_Membrane-fusion_protein, RND family efflux transporter, MFP subunit. This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate].	2.65442e-59

>NC_016025.1|WP_014101117.1|462832_463759_+|hypothetical-protein
MGKVFRPSLAVLFTWAVIPGLPWVITAQTAKKEKPPAAASSAPADPLVNLEQPRTSIPPEMLSAPPSGVRVILSQFALALDTLPPTEQLPMFLAAPSPLRYWTFSLLDPNVRRRLLELMEAEAIRQWPAQEKVIRSFLTKTQAAYDRQRMPEDTPEQFKLKNEVGLRYLAELSPEERAIGRQMHTYFFGPSILLRYQGRVWIRPEAVPQIEAFLKRVPALREYKTDELFVVFSGKTSSPVFFQDYETDGLFVGVRGPTCNCALDVDCVPGTFCQTTKPPYPTDFGTTCHMFGVRLPCSGFCTPGKPRR
>NC_016025.1|WP_041569985.1|460480_462709_+|VWA-domain-containing-protein
MLLTALITGWLPLAILAQKPPAPPAAPGTPPADAPKAAGQEPAPGQGEDEEDVITLGTELLQLYVSVTDKQGRPVNNLQREHFVLREDGKPQDIAFFSAVANGVLADDPEASTEPENRLRPPAVTPEGRYFALVVDDLHIAPGNFLPLRNALLNFVEKNIVEGDHLLVLSTSGTLGFLQQMTDDRRIMRLAIERLTPRNEAVDQGSFGFGFTMTDYEAFLVERNDRQTIDFLTQLYIRSSPGTPPNQAETLVRASARSLAQRTEYLTTSTLETIRAAALALGNYPGRKTLLLATDGFINDEFNRNGRFRIQRVLDAATRAGVTVYSIHSAGLEVAAGFDASQPGRFDPTGIGLSLASQAQQARQDAFRELAAATGGLTFVNTNDLSGAFSKAVADASTYYALAYYPDKKPDGRFHKIEVKLNLPGSFTIRTQQGFFSPSEKSIQKAAEKKKKQDAKLSPEALAAREVKAALGAPVPPRDIPLRLASTFVSNDLETSFSLAFPLKNIAFRDVKGRKSNTLTMGFVVFDLNGKALMAQEDTIALNILPERLALAQAGWGSQTKSLKLAPGMYNVRAAIYDPITEHRGAVNRWIEIPNVSKAGMMLSDIIFLQVAQPTATEPGDSQPVAGQALPPNLAPINQAVRRYPAGAQLVFVVTAHNVPKGKPTAGKSNLAFQIQIFRDKEAVYVSPLQRTQSPPNADGTLTYAGQVSLEGLAAGQYRLKLVAYEETTKKTAVQSQDFTIH
>NC_016025.1|WP_014101114.1|459580_460279_+|leucyl/phenylalanyl-tRNA--protein-transferase
MPILEFPPVEEADEHGLLAVGGDLHVSSLLLAYSNGIFPWPHEGYPMLWFAPAERAILDFDDFHIPSRLARYLKKVNYTFHINTDFAAVIHACRTSVRKRQQGTWITPEIEAAYTALHEAGHAHSFEARTPDGELVGGMYGVMIGRAFSGESMFFRAPHASKFVIVETVAYFRQHGMTWFDIEVMTPHMALFGAKEIPRAEFMRRLKQAIAQPPIPLPPPRRRRIPHSALFS
>NC_016025.1|WP_014101113.1|457945_459202_+|formylglycine-generating-enzyme-family-protein
MLSLATPVGWTAPSQEISTRVGNTQPVRVVRVTPKRVATVIRLSEEDREWNAIRNSNDPQAFKTFLAKYGSGSKYGRLAEQLAENAEIERLRGRDRRYTDAPLIMRELAFDEFQTVDLTPEGNIVNPRILKSEVVAIELDREKGIALELVRIPGGEFRMGSPESEAGRLPNEKLHEVAVPEFYMGRYEVTRRQWAFVAALPKVRDDLPPNPSQPEAPRGRRSPRAPQNNDNTDMLPVENVTWSQAVEFCRRLEKITGKRFRLPTEAEWEYACRAGSTKPFAFGDTLTTRVANINGEVPYGAAKVTPTAGRLLPVGSLGIANAFGLFDMHGNVWEWCQDAFVEDYDNAPTDGSAYDVVNPIYRVRRGGSATYKAELCRCAMRGRAEPERTGPCITCTGGTGLRVAILAEDLKLTDDDAE
>NC_016025.1|WP_014101111.1|456312_457596_-|HEAT-repeat-domain-containing-protein
MKGLPVLWVLFASFCTAAAIVLTIRWLYRRAAQPRRRPLREILANLEHARPTRRVRAAGELSERTGAEAREAVDALLRRLSDPEPEVRAVVVDTLGKLEDPRASEPLRERLHDDSTEVRGLTVSALVSLRDFAALPEIIRLLDDEDWTIRAWTASEMVRLGREEALETLLAARNREVWRAHLRLCDSAPRVVDERAVSPLLIEMRKAKEMGIRVEAMLALASFGYIPDEEARLVENLVASTEEEHPNLRFQAIAMLGTMEMRRIEPYQQAQRILERLAVRDENALVRAAARHSLKNFTIVRERTIRSLPPPEAMPAVSPVRVEMQSLDMLTSNLKNTALPMRWRYVHALAATRHPKAVVPLIEATHDKEWRVRAAAARGLGLLVGVGETDVRPTLERAAIEDEHFSVRETAELALARITPTSTPRSR
>NC_016025.1|WP_187288474.1|455593_456256_-|TetR/AcrR-family-transcriptional-regulator
MTLYRLDGTVRAMRRPSTKSATPAQVTRDELLRATVRVVAEEGLPRLTLDAVARAAGVSKGGLLYHFPTKEALIRALIETFIAEWDRAMAREYARDPEPEKPGRWLRAYVRASFAEVDPNESLTLGLGQGDLASFLAALAVNPELLGLIQTAYDRWHRLLVSDGVDEVTATAVRFAADGIYFAEGFGLAPPVGRQRQQVCDLILAWSAAPGRTGTEMAGA
>NC_016025.1|WP_014101109.1|454257_455592_-|efflux-RND-transporter-periplasmic-adaptor-subunit
MGHREGEQLSVRRCGSNGLAAWGVGGLCLVALVLGVGCQRPAQNQASAATEAPTPVTVARVQVRMRPQSILATGNVVPWRQSAVASAAMGKVVDIPVDVGAVVREGQVLARLDDREARQRLAQAEAALAQAEAAEAQLRARLGLTGEVFDPRQTPEAEAAQAALTAAEAEARLAGATLERYERLARHDNITRAVLDEARTRLEAAQAQVQAARRRYAAILDGLRAEYAGLRAAQARIAEARAAVALAQKAVEDTTVRAPFAGYVAERFANVGEYVTPEKPLMELVVLERLKLELQVPAGEAGRVRRGQAVEATTDAYPDWVIRGEVTTIRPLVEADARRLRVEVIVSNGEQRLRPGMFVTARLLLAERTPWVMAPRAAVRWHPGLGAQVAYVVEGDRARLRVVQVGEGVGGEVEIRSGLEAGERVVVTGLEKLEDGKAVSSTDR
>NC_016025.1|WP_014101108.1|452424_454254_+|hypothetical-protein
MFVCLIVWFFISILSVFSAFSLLSIFLEKKEIIKLLGIQPFLTSFIGTLALSNLFMILAFFSSLRTTHLVVVSIAVLSYAFFSLTRQDVQTLADILRENFLTMLISSALSFFLISIPHHEASDIVGYHIQMAKYLHEYGLVTGLALIHPQLGHQSIWFALPAPFEDFLGIYSSLIVGGFSLFISFCQFFRSLSRINKDIYEFFLVCFFLLSFVAFYARVYVTSVEVPLNIIIGMTVFCSLRYFSSEDETPDSEVKHLFFWPAVIFPSFGFALKLTGIPVFLFGIYLFIHRFGFKLNKSHLRWGIITTILVLTKLTASALTSGCPLYPSSLFHLQAPWFIGENSSKEVIELITTFARLEVTKAPENINHLNWIFPWSKTLGGKGVIYLFIFLMILILSCILVLKKDFLIFCKKYTSVLLFAAVGVLYVFINAPRIKFMGPYIITMVSMFLLATFQKDAILSSLSLVASFSISEIMVANRKLGLIQALLLLLLVISSTLYREKYKQFIFLTAYTHKLVLHLAYFTALTFYSSTNTNLLLLPEVSSLKRQFTSQDINGVKFFFPKNSISCGYSPLPCSLGKVWSEFSLEDIELIDKEKGIAGGFKRKNYSPE
>NC_016025.1|WP_014101107.1|449276_452390_-|efflux-RND-transporter-permease-subunit
MQWLAEICIQRPVFTTMLIVAIAVFGLVGYGTLGVDRFPNVDFPVVTVVIANPGASAVEIERDITEKVESAVNAISGVKEIRSTSVEGISQVNIQFSLNKDFDVAAQEVRDKVNLVIPELPKTIEPPTVQKFETNASPVIRLAVSAPYPLVETTRLARRQIKEQLETLDGVGRVALLGGVQPEVRVTLDPLRLRAYDLTPLDAVAAIERQNRDAPAGTLEQGARETALRAPGKVPDAATLRRLPLAYRQTYPVCLEEVAHVEETTPLPRTITALDGRSAVIVQVSKRAGGNAVALAAAVKARLTEIRASLPPEVTVTEVGDKSIFIEAAVNDVKTHLLEGSLLACLVVLVFLRRLGLTLIAALAIPTSIIGAFGVMATFGYTLDTITLLALTLMVGVVIDDAIIVLENIERFIREKGLPPFEAAVAATREIGLAVLATTLSLLAVFLPTAFMGGIVGRFLAPFGITAAAAVAISMFVSFTLTPMLCARMAVSHPDRPAAAGWTARYYGPLVDWSVRRRGWVALMCLGVAASVVPLFIVIGKDFIPQDDESEFEVTLRAPEGTSLAAMSLLVERIAADLRTLPGVAHTLTTAGSGDPPVASRGYIYVKLRPLAERTASQRELIGLARERLRPYAAQVRTSVQPITPFAGGGYENATIQYVLRGPELEPLALYAERLMEAMRRMPGVVDVNSTLVLGAPELRLVVDRARAADLGVAVEDVATTLNLLVAGVEVGTLAADAGAAADRPRIRLRATDAFRSLPERLGAIAVPTAKGAPVPLSGLVRLVEGTGPVAIERLNRQRYVTVLANVAAGYSLSAATEQIDAAFQALELAPGYERVFAGDAKDMAESAYYFAIAFGLTFVLMYVVLAAQFESFIHPVTILLTLPLALPFGLVSLLAVGQNVNLFVGLGVLVLFAVVKKNAILQIDHMNGLRRAGWARDAAIIQANCDRLRPILMTTLAFVAGMFPLALSRGPGASSNRSISVLVIGGQSLCLLLTLLAVPAFYALFDDLAAWLARRRWFRPRRSLGSEPSVKSAAHD
>NC_016025.1|WP_014101106.1|447859_449266_-|TolC-family-protein
MWRQETAMFLSRHVWLPVIIGVALSGNSAPAQHLPPVRRLPVPGVVYPPAGGHAPRPLSPARAVEMALAGETSVRLAAERREEARGRALEARAALLPNLSGVVTRANSAINLAAQGLGGFLPGISSIIVFDTFDARLQLAQQLFDWSAVQRHRATQTARQAAEVEAQLVRQQITGEVLLAYLDVLRAQSLVSAAEREIVTARALVHLAQEQRAAGLATQLDVVRAGVRLAEEDARRAQAQVELEQAQARLRRLMAVPADAELTLTGELRFVPVSTPDVATAQSAALRQRLEVVLARLQYEAATREQAAVAAEHLPSVEVFADYGLNGVRPNRFALPTRTFGVRVNVPVFNGGASFGRLVAEKSRARQRELEVADVQRQVEQEVRLAVVLLSAAAEQVAAAEQAVTLAQREVELAEERFAAGVADNLEVIRAQSALSQARTARIQALAQHVMTRVNWALALGTIEQFQW
>NC_016025.1|WP_148264149.1|466399_469924_-|hypothetical-protein
MMTHGAMLWGAALYNNGAYPYKDTRWGESYNQDGAPQALMSLKPPTPSERKYRGIIPFITPLPRWEVTQPGNILRVFERGGRKQSEVGNPNPEADLAGLPEVKLSPRGFGTGLRTDPVFLGLQKTRLLDPLTSLMGTNDHPGDYRSSGCTACHTPYANDRSTVHSSTKFDYAHTNRGTTKTADPTIPKDEPGHPVRHVLTNAIPTSQCMVCHMHPGTNMLTTYQGFMWWDNETDGRPMYPETPLKRSDEELENIARHNPEGSAQRGKWGDRAFLGEVWTEVNPKAKRTQFADFHGHGWIYRAVFKQDRKGRYLDENDQPVPNVTPEALRQAVAYTSEGVEVNKTTVRSGVPVHLKDIHLEKGMHCVDCHFSQDGHGDRLLYGEPRAAIEISCQDCHGSIYAYANPKSLTTGFAGGARKKSADDALVTGKFTARNKTDAEAPGGSNSLDGYKTRTVYERDPSKRRARGFRQASVLEIPTAGPYKGKVIQYSMVDPEKFWVVVQTKDTVTPGHEHYSEKSHYAKLLMKGNVWDPAAKPDEGKDSQLAHSDQRMTCYACHSAWMTSCFGCHLPMTANRKRPMNHNEGGPETRNWTSYNFQVLRDDVFMLGIDGTATGNRIAPVRSSSAVIVGSQNANRLWLYSQQQTISSEGYSGQAMNTHVPHTVRARETKGCTDCHISKDNDNNAIMAQLLLLGTNYVNFMGRYIYVAEGKHGISAVVATERSEPQAVIGSTLHEIAYPKEYKKHKAGGDKLHEHYHHHGHALSLQMRGEYLYVAEGEHGVHIYDIANIDNKDFSERITTAPVSPLGQRFYVKTKYATAIASPTTLGVDPTRQRFPENEEQPISPVYAYLYVSDREEGLVMINAATLLDGDPTNNFLKKDYTFNPNGLLNGAENLTVAGDHAYILCDRGLVIVNVANAAAPKVVSIVEGFRKPKGIAIQFRYAFVTDAVGMHVVDITLPEKARLVPGATIPLEDAHQVYVARTYAYIAGGKQGLVIVDVERPEQPKIDQIFTAGGVINDARDVKVGMTNASAFAYVADGKNGLRVVQLTSPETMATNGGFSPRPEPRLIATHPTKGESLAVSKGLDRDRGVDESGHQLVVFGRRGARPFNLEEMRRLYLKPDGTIYTVSNEVPKGPTKGWYAEAQPPPSKSVSWWPLGWLALFAVITPFALRRRR
>NC_016025.1|WP_049787537.1|470677_472564_-|hypothetical-protein
MNQTRRLVALIVGWGMWLGCSVPAQNLTTVSEAALAPVVQEAQSRQDGARVPRTADAIPELRELTVPGAEGPSSVEPRSERRDSDVGVPIEDRWRIGFPEWNRYEKGSILNPYRLNVLKGDYPILGQHTFLVLTFESITFVDGRRTPLPQDINARRPGAAEFFGRGGQFLNQQNFVTSVELFHGDTAFKPPDWRIKFTPVFNLNYLAVRENGIVNRDVRKGTTRFDTHIGFQEAFAEVRLGDTPRLFPFLRGRGSRGGHSPFFDSTSLRVGVQQFNSDFRGLIFDDFNLGARLFGNFRDNKWQFNAAFFYMLEKDTNSGINTFDQRNQRVWVANLYRQDFIKPGYTMQLSVHYNDDQPSIKFDQNRFLVRPAQVGPVTPHSVKAGYIGWTGNGHFRRLNINHAFYQVLGRDSLQPIAGRPTRINAQLAALELSYDRDWQRFQVSGFFSSGDANPTDRVARGFDSILDNQFFAGGENSFWNSQEIRLTRAGVALVTQGSLIPSLRSSKLQGQANFVNPGIIVANLGYEANLTPKLKLLANLNYLRFHHTESLQLLTFQRRIRNNVGIDYGVGIVYRPLLSENMIVKGGFSVMNPLDGFKDIFTSNCSGLNCGAQSRFLFSLYAKAIFTF
>NC_016025.1|WP_014101123.1|472867_473413_+|DinB-family-protein
MDTTPELSREGLRERLTHSLEAAIRELTALSDAQRTCPLKPSRANPDIVWTPCDHFAHLIGTKRYFQREIEKALTENPEARPQPYANALNRPSEDTMAAVHAFNDQWILKHRDKSFAELVVMARETRAHTLDLLDRTSDDQLACSMPVPWGLATIGEVFDLQTRHMAMHLGFIREGLAAKA
>NC_016025.1|WP_014101124.1|473409_474639_+|MFS-transporter
MTSVPTPALAAVLLGNALMRIAGATGGVLIGLYLAALVAQGRTFDAGLVGALTAVAFGVELVGSLPMGLLADARTPRTMMVFGALLGAAAVQMFGLSSFVAVFFLARAGEGLAVAATTPSVLAFLTEATATDAVRRGKVMSFFEMSLLGGLAFGGLLASLLWQSIGVWGFSAVAGLYVAAAGLFLSGAQGRGTATNAWAGLRAALAAPMLRRLAPAWICINAMVGVWLGSTLPFLLTLPERRGQFLTGIFADRPEGVGWALLGYAVIFGTGVTGWSFILHRFRRITVLRLALGGLFVACLGFYALNHAGGQPSSIRWLIGGGTALAIMVESGFTPTALALLAEAVGEQAGRGATMGVYSVLLGVGAVTGALLGGLGAQWAAMDGLIAVTVLLALGAAAGVEWLARHTPG
>NC_016025.1|WP_014101125.1|474694_475486_-|hypothetical-protein
MTYAWRRRPAGQAPGHPAGRWLWWGLAFVLSLSLVASVEVAAQRRKPSRRTPPPPVSPMVGKDIRIKRMDGLEIVGKLVKLDLQGITYINAGGEQATIALENVAVLTLGEPVKRIDQRFVSDARQAVDALSRINTLVNGNPTFSQYDGLVVDARVAVESFLAKYNDYEEQTDFFDSLRSVLRSYELVRPLWATMQGADRRISLTESAPELIPILRMYPDLRATEYNQNGRYPTDKVIAYVWNRTAQRLRSVRAQLDQLASKAT
>NC_016025.1|WP_014101126.1|475499_476138_-|hypothetical-protein
MDWTTAPDAFIERCILAIGGRTALYGVRTLLMHVRRTVMQPPETIELEILRAFGGRIRLIERRPGCEPRVIVINGFAGQVMMQGRLAPLPALQLEAIKRRIRLYPRNFLAHAEEYDYAPPVADRDTDGDPIWRLDLPSEDVSYGFDAAHFQCRFLEDRETGERITYSDYVATDGILTARREQCWQAGQLVHEDDILYLAFNVPFDDADFTVL
>NC_016025.1|WP_014101127.1|476527_477208_+|VTT-domain-containing-protein
MTLAGFSAPFWKALLGKLQLFGMWLAGFGVFGVLLLAYVDSVIPLTPIPDATLALVCAQGTLWWWAAVLAALGSSLGCMTVYWLVRRLRQRFLGRSLLARRLSPERQARIEQLIRQYDIVALAAAAVMPPPFPFKPFVICAGLLEFHQGRLFVGLFIGRAIRYGTLAYLSMRYGSEAMSLLQQHTGWFFLGVGVIVALLGIYFLVRWYVFRRPALTATSLSPDIQP
>NC_016025.1|WP_014101128.1|477223_477640_+|hypothetical-protein
MNFLRYGCSSFLALGGLVVAFLALYDAFQPNRHWGLIAGMFIGGVAAFLGGTAVIEMANASRRRRGEAEAAAWLPRLAAEHGVITVQMIEDRTPLSATQTRRWLEREVAAGRLERLGPERYALVNAKPSSESSPSDRA
>NC_016025.1|WP_014101129.1|477689_478289_+|Uma2-family-endonuclease
MSSLPHIRLTPDEYLAAERWATHKSEYVAGEVFAMSGATLRHSLIATNIAAELRQRLKGRDCTVHASDLRVGTPAGNYFYPDVVVVCGEPVYADDHRDTILNPILIVEVLSDSTQDYDRGGKFAEYRRLASLQEYLVVAQTAPCVEHHTRQADGCWLLHETSDLTAVLTLASIGCQLPLAEIYDKVTFAVANPVEGATP
>NC_016025.1|WP_014101130.1|478285_479302_+|isocitrate-dehydrogenase-(NAD(+))
MKHLVTLIPGDGIGPEVTAATLRVLSAAGVDITWERFPAGAQALAEHGTTLPDALLSSIRRTRVALKGPVTTPVGGGFTSVNVGLRKALDLYANVRPVKSIPGVRTRYENVDLVVVRENTEDLYSGLEHVVVPGVVESLKVITERASTRIARFACDYARKHGRRKVTVVHKANIMKLSDGLFLDCFRKVVQHYPEVQPEEKIVDNMCMQLVMHPERYDVLLMENLYGDILSDLATGLVGGLGVVPGANIGDGMAVFEAVHGSAPDIAGRGLANPTAMILSATMMLRYIEENQAADRIEAALFAVLGEDGIKTPDLGGTATTTEFTEAIATRLTDNPDN

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Crispr_ID: NC_016025_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016025_4

984883-988627

Unclear

Consensus_repeat	Method
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	PILER-CR
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	CRISPRCasFinder
NGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCN	CRT

51 spacers

cas2,cas1,cas8u1,cas3,csb2gr5,cas7,WYL

The CRISPR arrays of NC_016025_4

>merge|NC_016025|4|984883-988627|PILER-CR,CRISPRCasFinder,CRT
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCATCGCTGCCACAGCCCTGCTCCATCTGGCGGAAGCCGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCTTTCCCATGAGGCGGTGCGCTGGGTGCTCTGCTTCGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCACGGAGCGGTTTGCCGCTTTGTTGCCGCCCGAGGTGCCGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCCTCCGGGTCGCCGGACCACGTCCACGCATACAGCAGGGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCCCAGGCGGCGGAGTAGGCGCTCCAGCGCCGCCCAAAGGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCTCAACGATACTGAAGCGGTCGTCCAGCACGAAAAGGGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCGGCAAACGGGTGAACAGGCTGCTTGAAGTGATGCCGCGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCTCAGTCGTTGGCGCGCCGTCAAGAGCTTCCAGTACGCGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCTGGCGCGTAGTTTCCCACCTAGCGTCCATCAGCGCCTGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCCTTGACGCGAACGTTTTGCTCGGGCGGCTGATTGGCCAGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCATTCTTACCGGCTGGCCTTCTTGGTCTACCCATACCGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCCCCTTGACGGTGGAGGCTACGGGCGGGCTGCTCGCACGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCGCAACCGCGTGACGGGACGCTGCGTAGCGATCACCGTGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCACTGCACAACCGACATCGCGAACTGCTTGAACGCTTGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCATTGACTGGAACAGCGACGAAAACGCCTTCTTTGACGGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCGCGCCTGCGCGCCTATCTGTGCCCGGCGGGTGTCTGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCATTGACTGGAACAGCGACGAAAACGCCTTCTTTGACGCGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCGCCCGGTTGCGGCAAATGCGCCGTATATCGTTGGCGGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCATCCCGACGTTGCCCGCGCCGATTGTTTTGTCAGCGGGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCGGGACTTCTGGTTTCACAGGTGGGTTCTTGCTGATCAGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCTCCCAGCGCCAGTCTCTGGCGCGAACCAGCGCCAGGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCTGCAAGGACGCTTTGACGCAATGGCCGGAGACAAGAATGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCGCTAGCGAACTGGCGGGGTAGCCCCTACGGGGCTATAGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCAACAGCGGGAGCATCTTTTCAGACGCTGGCAATCCGTTTTCCGCTTTGAAAAAAGGCGGCTCCATTGAAGCAGACAGTCTCCGCTGGTGGCTGAAATGTCCTGGGAGTAGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCCCGGCTCCGGGACGCCACAGGGTTCTCCGGCAACCGGCGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCTACGAAGAGCGTGACGGCAAGTTTGTCCTGCCGGTGGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCGTGACCGGCGGCGCGCCGGACGGCTGGATGGTGATGGGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCATCCGCAAGGTGGCAGAAGAAGTTGGCGTCTAACCGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCCGCAAGCCGACACGACAAGTGCCGGGCTGCTGATTCCGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCGGTTACGTCCCCGCTCCTACCAGCGGTCAGGTTACGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCGGGATTTCGGCGAGGGAAAGATTGACAGTACGCACGGGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCCAGATGGTGCTCCGCGGCAAGCTGACGCGCCAGTTGCGGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCTGTGACACGAGGTGTGCCTCGTCAATAACGACGAGATGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCGGTGCATAACTTATTGATCTGACTGGGCTTAGCTGGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCTTGACACTGTAGTGCGGCGTCCAGTGCCAGCGCGTGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCCGGCTTGGTCACGGGCTGATTACCGATCCGCCAGCGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCACCTGCGTTTATGGCCCGCCGGCCACTGTTTGATTCGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCTAAATCCGGTCGTCGTCCTTGCACACGGCGTAGTAGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCTCAAGGCGCCACGCGACCTCTTCGTTGTCGTGCTCCTGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCCCGGCGCCGGTCGGGATCGCGTGCAAGGGGTGCCGACATGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCCGCGTCGGACAAGTGTGACAGGCGGACACACGGGACGGTAGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCTAGACCTTGCCCGGCTCCGGCTCAGGCAGGCCAATGACCGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCGCGCGAACAAGGGCGAGCTTAGACTGGGGGAGCGGGGAGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCCGGCGTGACGCCCGCCAGAGATCGAGTAACTCGATGGCGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCAGTTCACAATCTCCATTTCGTTCTCCTTTCTTTTTCGGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCGCTGCGGTGAGTTCGGCAATCAGTTTGCCCCGGCAGGGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCGCGGTCAGCGTTAGCCTGTGTCAGTTCGCTTCTGACGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCGCAAGCCTATCTCGACGCCATCGCCCGTCGGGCTGAAGGTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGCTGCTATGCTGCCCTGCTTGAGGAAAGTGCCCGTCTTGAGTTTTCCGCTTTGAAAAAAGTTGCTTCATTGAAGCCCGATGCTTGACAAGACAACCAAACTGTGCCAAACTTTTTCCACTTTGAAAAATTGGCTTCATTGAAGTG

>NC_016025|4|4|984883-988484|PILER-CR
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	ATCGCTGCCACAGCCCTGCTCCATCTGGCGGAAGCC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	TTTCCCATGAGGCGGTGCGCTGGGTGCTCTGCTTC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	ACGGAGCGGTTTGCCGCTTTGTTGCCGCCCGAGGTGCC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	CTCCGGGTCGCCGGACCACGTCCACGCATACAGCAGG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	CCAGGCGGCGGAGTAGGCGCTCCAGCGCCGCCCAAAG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	TCAACGATACTGAAGCGGTCGTCCAGCACGAAAAGG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GGCAAACGGGTGAACAGGCTGCTTGAAGTGATGCCGC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	TCAGTCGTTGGCGCGCCGTCAAGAGCTTCCAGTACGC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	TGGCGCGTAGTTTCCCACCTAGCGTCCATCAGCGCCT
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	CTTGACGCGAACGTTTTGCTCGGGCGGCTGATTGGCCA
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	ATTCTTACCGGCTGGCCTTCTTGGTCTACCCATACC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	CCCTTGACGGTGGAGGCTACGGGCGGGCTGCTCGCAC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GCAACCGCGTGACGGGACGCTGCGTAGCGATCACCGT
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	ACTGCACAACCGACATCGCGAACTGCTTGAACGCTT
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	ATTGACTGGAACAGCGACGAAAACGCCTTCTTTGACG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GCGCCTGCGCGCCTATCTGTGCCCGGCGGGTGTCT
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	ATTGACTGGAACAGCGACGAAAACGCCTTCTTTGACGC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GCCCGGTTGCGGCAAATGCGCCGTATATCGTTGGCG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	ATCCCGACGTTGCCCGCGCCGATTGTTTTGTCAGCGG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GGGACTTCTGGTTTCACAGGTGGGTTCTTGCTGATCA
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	TCCCAGCGCCAGTCTCTGGCGCGAACCAGCGCCAG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	TGCAAGGACGCTTTGACGCAATGGCCGGAGACAAGAAT
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GCTAGCGAACTGGCGGGGTAGCCCCTACGGGGCTATA
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	AACAGCGGGAGCATCTTTTCAGACGCTGGCAATCC
GTTTTCCGCTTTGAAAAAAGGCGGCTCCATTGAAGC	AGACAGTCTCCGCTGGTGGCTGAAATGTCCTGGGAGTA
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	CCGGCTCCGGGACGCCACAGGGTTCTCCGGCAACCGGC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	TACGAAGAGCGTGACGGCAAGTTTGTCCTGCCGGTG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GTGACCGGCGGCGCGCCGGACGGCTGGATGGTGATGG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	ATCCGCAAGGTGGCAGAAGAAGTTGGCGTCTAACC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	CGCAAGCCGACACGACAAGTGCCGGGCTGCTGATTCC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GGTTACGTCCCCGCTCCTACCAGCGGTCAGGTTAC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GGGATTTCGGCGAGGGAAAGATTGACAGTACGCACGG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	CAGATGGTGCTCCGCGGCAAGCTGACGCGCCAGTTGCG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	TGTGACACGAGGTGTGCCTCGTCAATAACGACGAGAT
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GGTGCATAACTTATTGATCTGACTGGGCTTAGCTG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	TTGACACTGTAGTGCGGCGTCCAGTGCCAGCGCGT
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	CGGCTTGGTCACGGGCTGATTACCGATCCGCCAGC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	ACCTGCGTTTATGGCCCGCCGGCCACTGTTTGATTC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	TAAATCCGGTCGTCGTCCTTGCACACGGCGTAGTA
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	TCAAGGCGCCACGCGACCTCTTCGTTGTCGTGCTCCT
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	CCGGCGCCGGTCGGGATCGCGTGCAAGGGGTGCCGACAT
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	CGCGTCGGACAAGTGTGACAGGCGGACACACGGGACGGTA
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	TAGACCTTGCCCGGCTCCGGCTCAGGCAGGCCAATGACC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GCGCGAACAAGGGCGAGCTTAGACTGGGGGAGCGGGGA
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	CGGCGTGACGCCCGCCAGAGATCGAGTAACTCGATGGC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	AGTTCACAATCTCCATTTCGTTCTCCTTTCTTTTTCG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GCTGCGGTGAGTTCGGCAATCAGTTTGCCCCGGCAGG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GCGGTCAGCGTTAGCCTGTGTCAGTTCGCTTCTGAC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GCAAGCCTATCTCGACGCCATCGCCCGTCGGGCTGAAG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC

>NC_016025|4|4|984883-988557|CRISPRCasFinder
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	ATCGCTGCCACAGCCCTGCTCCATCTGGCGGAAGCC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	TTTCCCATGAGGCGGTGCGCTGGGTGCTCTGCTTC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	ACGGAGCGGTTTGCCGCTTTGTTGCCGCCCGAGGTGCC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	CTCCGGGTCGCCGGACCACGTCCACGCATACAGCAGG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	CCAGGCGGCGGAGTAGGCGCTCCAGCGCCGCCCAAAG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	TCAACGATACTGAAGCGGTCGTCCAGCACGAAAAGG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GGCAAACGGGTGAACAGGCTGCTTGAAGTGATGCCGC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	TCAGTCGTTGGCGCGCCGTCAAGAGCTTCCAGTACGC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	TGGCGCGTAGTTTCCCACCTAGCGTCCATCAGCGCCT
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	CTTGACGCGAACGTTTTGCTCGGGCGGCTGATTGGCCA
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	ATTCTTACCGGCTGGCCTTCTTGGTCTACCCATACC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	CCCTTGACGGTGGAGGCTACGGGCGGGCTGCTCGCAC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GCAACCGCGTGACGGGACGCTGCGTAGCGATCACCGT
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	ACTGCACAACCGACATCGCGAACTGCTTGAACGCTT
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	ATTGACTGGAACAGCGACGAAAACGCCTTCTTTGACG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GCGCCTGCGCGCCTATCTGTGCCCGGCGGGTGTCT
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	ATTGACTGGAACAGCGACGAAAACGCCTTCTTTGACGC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GCCCGGTTGCGGCAAATGCGCCGTATATCGTTGGCG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	ATCCCGACGTTGCCCGCGCCGATTGTTTTGTCAGCGG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GGGACTTCTGGTTTCACAGGTGGGTTCTTGCTGATCA
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	TCCCAGCGCCAGTCTCTGGCGCGAACCAGCGCCAG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	TGCAAGGACGCTTTGACGCAATGGCCGGAGACAAGAAT
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GCTAGCGAACTGGCGGGGTAGCCCCTACGGGGCTATA
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	AACAGCGGGAGCATCTTTTCAGACGCTGGCAATCC
GTTTTCCGCTTTGAAAAAAGGCGGCTCCATTGAAGC	AGACAGTCTCCGCTGGTGGCTGAAATGTCCTGGGAGTA
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	CCGGCTCCGGGACGCCACAGGGTTCTCCGGCAACCGGC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	TACGAAGAGCGTGACGGCAAGTTTGTCCTGCCGGTG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GTGACCGGCGGCGCGCCGGACGGCTGGATGGTGATGG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	ATCCGCAAGGTGGCAGAAGAAGTTGGCGTCTAACC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	CGCAAGCCGACACGACAAGTGCCGGGCTGCTGATTCC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GGTTACGTCCCCGCTCCTACCAGCGGTCAGGTTAC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GGGATTTCGGCGAGGGAAAGATTGACAGTACGCACGG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	CAGATGGTGCTCCGCGGCAAGCTGACGCGCCAGTTGCG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	TGTGACACGAGGTGTGCCTCGTCAATAACGACGAGAT
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GGTGCATAACTTATTGATCTGACTGGGCTTAGCTG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	TTGACACTGTAGTGCGGCGTCCAGTGCCAGCGCGT
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	CGGCTTGGTCACGGGCTGATTACCGATCCGCCAGC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	ACCTGCGTTTATGGCCCGCCGGCCACTGTTTGATTC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	TAAATCCGGTCGTCGTCCTTGCACACGGCGTAGTA
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	TCAAGGCGCCACGCGACCTCTTCGTTGTCGTGCTCCT
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	CCGGCGCCGGTCGGGATCGCGTGCAAGGGGTGCCGACAT
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	CGCGTCGGACAAGTGTGACAGGCGGACACACGGGACGGTA
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	TAGACCTTGCCCGGCTCCGGCTCAGGCAGGCCAATGACC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GCGCGAACAAGGGCGAGCTTAGACTGGGGGAGCGGGGA
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	CGGCGTGACGCCCGCCAGAGATCGAGTAACTCGATGGC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	AGTTCACAATCTCCATTTCGTTCTCCTTTCTTTTTCG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GCTGCGGTGAGTTCGGCAATCAGTTTGCCCCGGCAGG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GCGGTCAGCGTTAGCCTGTGTCAGTTCGCTTCTGAC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GCAAGCCTATCTCGACGCCATCGCCCGTCGGGCTGAAG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	TGCTATGCTGCCCTGCTTGAGGAAAGTGCCCGTCTTG
AGTTTTCCGCTTTGAAAAAAGTTGCTTCATTGAAGC

>NC_016025|4|3|984883-988627|CRT
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	ATCGCTGCCACAGCCCTGCTCCATCTGGCGGAAGCC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	TTTCCCATGAGGCGGTGCGCTGGGTGCTCTGCTTC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	ACGGAGCGGTTTGCCGCTTTGTTGCCGCCCGAGGTGCC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	CTCCGGGTCGCCGGACCACGTCCACGCATACAGCAGG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	CCAGGCGGCGGAGTAGGCGCTCCAGCGCCGCCCAAAG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	TCAACGATACTGAAGCGGTCGTCCAGCACGAAAAGG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GGCAAACGGGTGAACAGGCTGCTTGAAGTGATGCCGC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	TCAGTCGTTGGCGCGCCGTCAAGAGCTTCCAGTACGC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	TGGCGCGTAGTTTCCCACCTAGCGTCCATCAGCGCCT
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	CTTGACGCGAACGTTTTGCTCGGGCGGCTGATTGGCCA
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	ATTCTTACCGGCTGGCCTTCTTGGTCTACCCATACC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	CCCTTGACGGTGGAGGCTACGGGCGGGCTGCTCGCAC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GCAACCGCGTGACGGGACGCTGCGTAGCGATCACCGT
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	ACTGCACAACCGACATCGCGAACTGCTTGAACGCTT
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	ATTGACTGGAACAGCGACGAAAACGCCTTCTTTGACG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GCGCCTGCGCGCCTATCTGTGCCCGGCGGGTGTCT
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	ATTGACTGGAACAGCGACGAAAACGCCTTCTTTGACGC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GCCCGGTTGCGGCAAATGCGCCGTATATCGTTGGCG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	ATCCCGACGTTGCCCGCGCCGATTGTTTTGTCAGCGG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GGGACTTCTGGTTTCACAGGTGGGTTCTTGCTGATCA
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	TCCCAGCGCCAGTCTCTGGCGCGAACCAGCGCCAG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	TGCAAGGACGCTTTGACGCAATGGCCGGAGACAAGAAT
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GCTAGCGAACTGGCGGGGTAGCCCCTACGGGGCTATA
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	AACAGCGGGAGCATCTTTTCAGACGCTGGCAATCC
GTTTTCCGCTTTGAAAAAAGGCGGCTCCATTGAAGC	AGACAGTCTCCGCTGGTGGCTGAAATGTCCTGGGAGTA
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	CCGGCTCCGGGACGCCACAGGGTTCTCCGGCAACCGGC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	TACGAAGAGCGTGACGGCAAGTTTGTCCTGCCGGTG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GTGACCGGCGGCGCGCCGGACGGCTGGATGGTGATGG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	ATCCGCAAGGTGGCAGAAGAAGTTGGCGTCTAACC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	CGCAAGCCGACACGACAAGTGCCGGGCTGCTGATTCC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GGTTACGTCCCCGCTCCTACCAGCGGTCAGGTTAC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GGGATTTCGGCGAGGGAAAGATTGACAGTACGCACGG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	CAGATGGTGCTCCGCGGCAAGCTGACGCGCCAGTTGCG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	TGTGACACGAGGTGTGCCTCGTCAATAACGACGAGAT
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GGTGCATAACTTATTGATCTGACTGGGCTTAGCTG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	TTGACACTGTAGTGCGGCGTCCAGTGCCAGCGCGT
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	CGGCTTGGTCACGGGCTGATTACCGATCCGCCAGC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	ACCTGCGTTTATGGCCCGCCGGCCACTGTTTGATTC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	TAAATCCGGTCGTCGTCCTTGCACACGGCGTAGTA
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	TCAAGGCGCCACGCGACCTCTTCGTTGTCGTGCTCCT
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	CCGGCGCCGGTCGGGATCGCGTGCAAGGGGTGCCGACAT
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	CGCGTCGGACAAGTGTGACAGGCGGACACACGGGACGGTA
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	TAGACCTTGCCCGGCTCCGGCTCAGGCAGGCCAATGACC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GCGCGAACAAGGGCGAGCTTAGACTGGGGGAGCGGGGA
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	CGGCGTGACGCCCGCCAGAGATCGAGTAACTCGATGGC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	AGTTCACAATCTCCATTTCGTTCTCCTTTCTTTTTCG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GCTGCGGTGAGTTCGGCAATCAGTTTGCCCCGGCAGG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GCGGTCAGCGTTAGCCTGTGTCAGTTCGCTTCTGAC
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	GCAAGCCTATCTCGACGCCATCGCCCGTCGGGCTGAAG
GTTTTCCGCTTTGAAAAAAAGCGGCTCCATTGAAGC	TGCTATGCTGCCCTGCTTGAGGAAAGTGCCCGTCTTGA
GTTTTCCGCTTTGAAAAAAGTTGCTTCATTGAAGCC	CGATGCTTGACAAGACAACCAAACTGTGCCAAA
CTTTTTCCACTTTGAAAAATTGGCTTCATTGAAGTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_016025.1\|WP_014101556.1\|992911_994588_+\|replication-initiator-protein-A	unknown	unknown	gnl\|CDD\|370826
NC_016025.1\|WP_041570041.1\|997520_998288_-\|hypothetical-protein	unknown	unknown	unknown
NC_016025.1\|WP_014101545.1\|974247_975327_-\|WYL-domain-containing-protein	WYL	pfam13280_WYL_CAS-I:CAS-III	gnl\|CDD\|379100
NC_016025.1\|WP_014101557.1\|994653_996573_-\|response-regulator	unknown	unknown	gnl\|CDD\|236901
NC_016025.1\|WP_014101559.1\|997194_997524_-\|hypothetical-protein	unknown	unknown	unknown
NC_016025.1\|WP_187288462.1\|991254_991968_-\|3',5'-cyclic-nucleotide-phosphodiesterase	unknown	unknown	gnl\|CDD\|293821
NC_016025.1\|WP_014101547.1\|976925_978476_+\|type-I-U-CRISPR-associated-protein-Cas5/Cas6	csb2gr5	cls000315_csb2gr5_CAS-I-U	gnl\|CDD\|274005
NC_016025.1\|WP_014101546.1\|975546_976920_+\|type-I-U-CRISPR-associated-protein-Cas7	cas7	cd09738_cas7_CAS-I-U	gnl\|CDD\|378223
NC_016025.1\|WP_081464993.1\|970488_971553_-\|polysaccharide-biosynthesis/export-family-protein	unknown	unknown	gnl\|CDD\|132073
NC_016025.1\|WP_148264141.1\|982645_984346_+\|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|376633
NC_016025.1\|WP_014101561.1\|998256_999207_-\|DNA-adenine-methylase	unknown	unknown	gnl\|CDD\|273146
NC_016025.1\|WP_014101548.1\|978479_981566_+\|type-I-U-CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09696_cas3_CAS-I-U	gnl\|CDD\|274235
NC_016025.1\|WP_014101543.1\|971777_972314_+\|molybdopterin-adenylyltransferase	unknown	unknown	gnl\|CDD\|181837
NC_016025.1\|WP_014101558.1\|996610_997198_-\|ferritin-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|372666
NC_016025.1\|WP_014101551.1\|984373_984670_+\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NC_016025.1\|WP_148264142.1\|999210_999975_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NC_016025.1\|WP_014101554.1\|989086_991162_-\|FHA-domain-containing-protein	unknown	unknown	gnl\|CDD\|143636
NC_016025.1\|WP_014101544.1\|972318_974295_+\|phosphoenolpyruvate-synthase	unknown	unknown	gnl\|CDD\|376527
NC_016025.1\|WP_014101549.1\|981607_982519_+\|hypothetical-protein	cas8u1	mkCas0114_cas8u1_CAS-I-U	unknown
NC_016025.1\|WP_014101553.1\|988823_989063_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_016025.1\|WP_014101556.1\|992911_994588_+\|replication-initiator-protein-A	gnl\|CDD\|370826	pfam10134, RPA, Replication initiator protein A. Members of this family of bacterial proteins are single-stranded DNA binding proteins that are involved in DNA replication, repair and recombination.	3.2761e-08
NC_016025.1\|WP_014101545.1\|974247_975327_-\|WYL-domain-containing-protein	gnl\|CDD\|379100	pfam13280, WYL, WYL domain. WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the WYL-like superfamily, named for three conserved amino acids found in a subset of the superfamily. However, these residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by a cysteine, which are predicted to line a ligand-binding groove typical of the Sm-like SH3 beta-barrels. A WYL domain protein (sll7009) is a negative regulator of the I-D CRISPR-Cas system in Synechocystis sp. It is predicted to be a ligand-sensing domain that could bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas and other defense systems such as the abortive infection AbiG system.	1.93257e-25
NC_016025.1\|WP_014101557.1\|994653_996573_-\|response-regulator	gnl\|CDD\|236901	PRK11360, PRK11360, two-component system sensor histidine kinase AtoS.	7.70326e-66
NC_016025.1\|WP_187288462.1\|991254_991968_-\|3',5'-cyclic-nucleotide-phosphodiesterase	gnl\|CDD\|293821	cd07735, class_II_PDE_MBL-fold, class II cyclic nucleotide phosphodiesterases Saccharomyces cerevisiae PDE1, Dictyostelium discoideum PDE1 and PDE7, and related proteins; MBL-fold metallo-hydrolase domain. Cyclic nucleotide phosphodiesterases (PDEs) decompose the second messengers cyclic adenosine and guanosine 3',5'-monophosphate (cAMP and cGMP, respectively). Saccharomyces cerevisiae PDE1 and Dictyostelium discoideum PDE1 and PDE7, have dual cAMP/cGMP specificity. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	1.82607e-47
NC_016025.1\|WP_014101547.1\|976925_978476_+\|type-I-U-CRISPR-associated-protein-Cas5/Cas6	gnl\|CDD\|274005	TIGR02165, CRISPR-associated_protein_GSU0054_family, CRISPR-associated protein GSU0054/csb2, Dpsyc system. This model represents a CRISPR-associated protein from the Dpsyc subtype (a type I-C variant), named for Desulfotalea psychrophila LSv54. CRISPR systems confer resistance in prokaryotes to invasive DNA or RNA, including phage and plasmids. CRISPR-associated proteins typically are found near CRISPR repeats and other CRISPR-associated proteins, have low levels of sequence identify, have sequence relationships that suggest lateral transfer, and show some sequence similarity to DNA-active proteins such as helicases and repair proteins.	1.12102e-59
NC_016025.1\|WP_014101546.1\|975546_976920_+\|type-I-U-CRISPR-associated-protein-Cas7	gnl\|CDD\|378223	pfam09617, Cas_GSU0053, CRISPR-associated protein GSU0053 (Cas_GSU0053). This entry is found in CRISPR-associated (cas) proteins in the genomes of Geobacter sulfurreducens PCA and Desulfotalea psychrophila LSv54 (both Desulfobacterales from the Deltaproteobacteria), Gemmata obscuriglobus (a Planctomycete), and Actinomyces naeslundii MG1 (Actinobacteria).	1.29471e-61
NC_016025.1\|WP_081464993.1\|970488_971553_-\|polysaccharide-biosynthesis/export-family-protein	gnl\|CDD\|132073	TIGR03028, EpsE, polysaccharide export protein EpsE. Sequences in this family of proteins are members of a polysaccharide export protein family (pfam02563) which includes the wza protein from E.coli. This family of proteins are homologous to the EpsE protein of the methanolan biosynthesis operon of Methylobacillus species strain 12S. The distribution of this protein appears to be restricted to a subset of exopolysaccharide operons containing a syntenic grouping of genes including a variant of the EpsH exosortase protein. Exosortase has been proposed to be involved in the targetting and processing of proteins containing the PEP-CTERM domain to the exopolysaccharide layer.	3.43877e-43
NC_016025.1\|WP_148264141.1\|982645_984346_+\|CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|376633	pfam01867, Cas_Cas1, CRISPR associated protein Cas1. Clustered regularly interspaced short palindromic repeats (CRISPRs) are a family of DNA direct repeats found in many prokaryotic genomes. This family of proteins corresponds to Cas1, a CRISPR-associated protein. Cas1 may be involved in linking DNA segments to CRISPR.	8.06939e-123
NC_016025.1\|WP_014101561.1\|998256_999207_-\|DNA-adenine-methylase	gnl\|CDD\|273146	TIGR00571, DNA_adenine_methylase, DNA adenine methylase (dam). All proteins in this family for which functions are known are DNA-adenine methyltransferases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). The DNA adenine methylase (dam) of E. coli and related species is instrumental in distinguishing the newly synthesized strand during DNA replication for methylation-directed mismatch repair. This family includes several phage methylases and a number of different restriction enzyme chromosomal site-specific modification systems. [DNA metabolism, DNA replication, recombination, and repair].	1.16016e-80
NC_016025.1\|WP_014101548.1\|978479_981566_+\|type-I-U-CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|274235	TIGR02621, CRISPR-associated_helicase_Cas3, CRISPR-associated helicase Cas3, subtype Dpsyc. This model describes a CRISPR-associated putative DEAH-box helicase, or Cas3, of a subtype found in Actinomyces naeslundii MG1, Geobacter sulfurreducens PCA, Gemmata obscuriglobus UQM 2246, and Desulfotalea psychrophila. This protein includes both DEAH and HD motifs.	5.48925e-75
NC_016025.1\|WP_014101543.1\|971777_972314_+\|molybdopterin-adenylyltransferase	gnl\|CDD\|181837	PRK09417, mogA, molybdenum cofactor biosynthesis protein MogA; Provisional.	2.02911e-110
NC_016025.1\|WP_014101558.1\|996610_997198_-\|ferritin-like-domain-containing-protein	gnl\|CDD\|372666	pfam13668, Ferritin_2, Ferritin-like domain. This family contains ferritins and other ferritin-like proteins such as members of the DPS family and bacterioferritins.	6.10834e-22
NC_016025.1\|WP_148264142.1\|999210_999975_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	1.41944e-11
NC_016025.1\|WP_014101554.1\|989086_991162_-\|FHA-domain-containing-protein	gnl\|CDD\|143636	cd07302, CHD, cyclase homology domain. Catalytic domains of the mononucleotidyl cyclases (MNC's), also called cyclase homology domains (CHDs), are part of the class III nucleotidyl cyclases. This class includes eukaryotic and prokaryotic adenylate cyclases (AC's) and guanylate cyclases (GC's). They seem to share a common catalytic mechanism in their requirement for two magnesium ions to bind the polyphosphate moiety of the nucleotide.	1.48487e-70
NC_016025.1\|WP_014101551.1\|984373_984670_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	3.51995e-16
NC_016025.1\|WP_014101544.1\|972318_974295_+\|phosphoenolpyruvate-synthase	gnl\|CDD\|376527	pfam01326, PPDK_N, Pyruvate phosphate dikinase, PEP/pyruvate binding domain. This enzyme catalyzes the reversible conversion of ATP to AMP, pyrophosphate and phosphoenolpyruvate (PEP).	1.47975e-55

>NC_016025.1|WP_014101551.1|984373_984670_+|CRISPR-associated-endonuclease-Cas2
MRSRYIVCYDIANPKRWRQVYRIMRGFGDPLQYSVFRCDLSATERVLLLMAVTEVINQREDRIMLVDVGPVDGRGRTCIEALGKPLEVAPTERITVVV
>NC_016025.1|WP_148264141.1|982645_984346_+|CRISPR-associated-endonuclease-Cas1
MLNEYVYCPRLFYLEYVQREWAENVDVLEGRFVHRRVDRPGGPAPVPAEITAESKIHARSVEVGCPELGAVAVIDLLESDDGQVVPVDYKRGAAPDLPEGAWEPERIQVCLQGLLLRANGYRSGYGIIYYAADKTRVQVDFTPALVARTKQLLAAARALAVSGAIPPPLVNSNKCPRCSLVGICLPDEINFLRGDDKASEATVATTLPSATEAPGGVLPAPTGREVRRLVPARDDNKAVYVQGQGYALGLNGTVLEIRDKGQAVDAVRLVEISQVNLFGNVQISAQALRALVNREVPVLHLSYGGWLQAVTTAPPHKNIELRRQQFQAAGDPDFCLRLAKAFVSGKIRNSRLLLRRNGRRLDPEVLSQLAALRNAVERCEELSSLLGIEGNAAREYFRHFSAMFKPENEPPFDFTGRNRRPPKDPVNALLSFAYSLLVKEMMVAVIGVGFDPHLGFYHQPRYGRPALALDLMEEFRPLVADSVVITVINNGEIGPSDFIQRGEAVALTPRGRKTFIEAFERRLDQLVMHPVFNYQVSYRRIFEIQARLLARTLMGEIPRYIPFVTR
>NC_016025.1|WP_014101549.1|981607_982519_+|hypothetical-protein
MTPNHHIVLRGLDGTTPLGFLAALGLVNALRECLPDLCLAWTTDEGGWVAQLGSSAPIRQADLLNWLDKMLVRSLDQHPARLYEEVKQQPGNVFLQVRQAAAVGHRREADFLAAIASNLAPAEATSQLQTTRRDYHVGNIKSILGRTTRSHLDRTLFKPWDYADPMDNQSLHLDPSEDRRHAYQWHKPSGDPTRRQRGTMLGANRLAIEAFAWFTVWPVGGALKTLGFSGFGSGETRWTWPIWTPFVPPDLIPSLLALAPLQDDPIGESDRRRLRHMGIAAVYRVRRILVGKTPNFTPARNIA
>NC_016025.1|WP_014101548.1|978479_981566_+|type-I-U-CRISPR-associated-helicase/endonuclease-Cas3
MTQVGIGDFDAFFREAHDCDPYPWQRRLAAAAVAGDWPPVLDLPTGSGKTAVIDIAVFALACQAALEPPARTAARRVFFCVNRRVIVDATYERALRLAGRLLEAEASPTRWPTLHKVAAALRQLSTLRPESAPPLDVLELRGGLYRDNRWARSVTQPMVVCTTIDQFGSRLLFRGYGVSAHAAPIHASLAAYDSLVFLDEAHISEPFRQTLCAVQDYLDPQRWAEEAIGVSPFRPVAMTATPPKAAGQAAFRLDHTDRRTPRLAAVLGADKLVQLRVVSDLPKDLVFEAKAMAETGQLAVGIIVNRVATARAVHRLLCEAFPDAPVELVIGPMRPVDRDAQQRRLMPRIGPDRPDRSAQLSFVVATQCLEVGADYDFDVLLTECASLDALRQRFGRLNRRGRPIAASAVVFIEVKALNPKKPDPVYGDALPKTWEWLTEWGQSDDVNFGIDAFDAYLNGQGLPVECLAPAARREPAVLLPAHLDLLCQTSPRPALEPNVGQLLHGPQPGEPDVQVCWRADLDAFPPDDWSEVVSLLPPTATECMTVPMSVVRRWLTGAEETGKDDAADLLELGGETAGTDAKPEAPDGSAVKPERRGLLWRGLADNRLLTAVSDLRPGDTLVFPVAAGGWEVVGHLPVDASPDAAEAASVTARNRPVVRLHPHLFDREWPALQELFARLAEPETVFGVEDWREALRALADDLQTGAEDKLPQHWPADALRTALHQLADPKLGLLRTPYPDGRGYVLTTRKRLAGRADWSLPLMDEGEDERSWIASAEPVTLAAHSRHVRDEIQRTVRALPLNIREEVFLAAAEAHDWGKADERFQALLQRADRTETWLLGASPLGLLAKSDGLPLTPLERRQAHERAGLPAGFRHEMLSVQMMETLLGSVGVPPAKPGNAGILPAEPGNVGVPPAERESTGLLPAELDLILYLIGTHHGRGRPLAPVVVDLEAPDVALTAELLGQSYTVAVSHAWREKAPPHRLDSGIGARFWRMQRRFGWWGAAYLETILRLADHQASADEEAGLVS
>NC_016025.1|WP_014101547.1|976925_978476_+|type-I-U-CRISPR-associated-protein-Cas5/Cas6
MLTLAWTYLTGYARATDPARRDAPEWPPHPARVWLALAAAFFETGEDPAEGHALEWLRTLPDPQVWLPLQAGGRRHVVTAYVPVNDKAEGTALLQSAPLARSKQPRTFPAVWVGDRPCFLHWPEAPDSDRYRPALTQLCARVTRLGHSASLVQMWVAERLPTPEDSFAGWLPTEEADSGLADLHLRRIFQGPSLERLRETFQAGRRPLVGLAAGYRAATFTPPPMTNTTAFDRDLLVLTQVDGPALPVTASLQVMQALRDTLMAHCPQPPPAWVSGHDAQGQPLADRRGHLALLPLPFVGYEYADGRLLGVALAFPTEIDRRERGRVIRPLFVNQQGKPADVSLRLGRLGVWVLRKRAWDDTRLTLQPETWTAFPRGAKRWASVTPVVLDRFPKANRLTERANWEYEVGSILFEACQYAGLPEPVEIDFGTTAWTPGAPRAIAKERPVRGASPPAQARLGDGFPPYLLKGARAAKPQVHVFLRFAEPVVGPVLLGAGRFLGYGLFKPLDFFVPKRS
>NC_016025.1|WP_014101546.1|975546_976920_+|type-I-U-CRISPR-associated-protein-Cas7
MSLSLQQLQQAVRTATALRCRLRLQPAGGPGTKVFPPTYEGGRYALEERRMPGYDHPVRCVLMDSVQSQANRMEEALQQAVDDGRLALPLVEVDFTPYFPGNGQPEDMRLLEPIGRVSSLQAPHRIVDAILRDSVVIQEQRKPFRSSNVKQESSYGRQLREAAAHHATPLFELCPTALLFGMWDSTGPKGGLGAKFERAMVSEIVGINAVLGAKTSSRIDPLGIQLKAGPLYRTPPTEPLGWTLDPGKAVKDNKGKPVLLGDTGRPSEANHGNVTRPSTSGSSRAGTGRPSEANHGNVTPTISERDRQGEFLGGGVTIDYAEQSIVLSLPALRRLRFPINGRNNRAADEAAWTVLAALGLCAAILADDAGLDLRSRCLLWPQEPLKWELLGRPGEIQSDIVLDAEAALRLFMEAVDEARKCGLPWRTTPLQLQPAPELVKLVVKSQQLAQSQGTQEE
>NC_016025.1|WP_014101545.1|974247_975327_-|WYL-domain-containing-protein
MLPVSPQADSKRGNLTRLAIELPLLLASGSKSKTELAKHFGCDKKTIKRLVDELSFHYRITEEKRGREVFYGFADGYTFRPPALKPAEVAALWLAQKAVLMDGSSPRWPLSQDGRSLLEKLRATLPPALAAHLGELAAVYGTALIPAKDYTPHVETLNQVLTAAIRKRRIEVEYVSLGSQHPKTRRYDPYGLYFDPNGGTLKTFGYDSRRRGIVTLAVDHMRQVTLLEERFTLPPDFTSVQSYLERYHFNGFFGEPLRVRLRFFGVTSQVFLERQHHVTQRIVSYTPATRGRPETVDIEMTVARGRGLERFILSWLPEVEVLAPATLRRRIEACRLGRARVLPPSAYRPRWPVAVNERA
>NC_016025.1|WP_014101544.1|972318_974295_+|phosphoenolpyruvate-synthase
MRAFCALCRAVRCHLAWSLALLLFCVSVVGAQSVPSAAVDAAAPADDPTAPDYVNRLTRADFDRLARLTRQGRGLDVPAVMFVIDRADGRVYYANSRRFRFHSDFARATYLTLDAGDVFLRHNYTNERRRFLLGTVTFQPRLERFTYEFWEGDLLTPSLLAEAHQRLTATGFAPLTFKANARRHEEIAAQLPDLPWVRAETTLPETTFLALNPGRAVGVLRLVEQLPPAQPFEREDIVIFKETPLSTTPLRGILVTQPGAPLSHLNLLAKGWGIPNAYVKDADVRFRSLVNRWVTLVVTDDGITLEPAEQITESERERELSRELRLPRADLRWRALTDLHRQRARDVVRFGAKSANLGEVAQARLPGIIVPRGFTIPFAHYKAFADRHGIEARVLALLNDEQFHHDPQTRQVELAKLRDFIVAAPFDRALRRAVLAKVHREYRGRGLFARSSTNAEDLPDFSGAGLYTTVPNIIGDEALITAIKTVWASIWNFEAFEAREAARIDHLAVYPAVLIQEGINADSAGVLVTTNPFDRRDAEGIYINAKRGLGLRVVEGRRIPEQIIYRPQSDAALVLTRADDETILTFDVKGGVREVAGVPDQPVLTADLIRRLGQAALAIERLFGGRKQDIEWLTYRGQLYIVQSRPFIDRNWPAGAVR
>NC_016025.1|WP_014101543.1|971777_972314_+|molybdopterin-adenylyltransferase
MTLSTITIGILTISDRASQGVYQDESGPAILAVLREYIANDWTPLMRLVPDEQPLIEAELRRLTDEDGCCLVVTTGGTGPAPRDVTPEATAAVCDKMLPGFGELMRAVSLQYVPTAILSRQTAGIRGRSLIVNLPGKPKSIRECLAAVFPAIPYCIDLIGGPYITGNPEHVTVFRPKT
>NC_016025.1|WP_081464993.1|970488_971553_-|polysaccharide-biosynthesis/export-family-protein
MLNRRHMLYLALWLLALPGLAGFSFAQETAPNPPSFPPVMPSPAVRATQVYTAPTGDYVIGPGDVVDIKVFKQPDLTGRFRVGDSGSVELLFIGKQQLAGLTESEAADLLRQELRKYLRQPEVSVTVTEFNSRLVTVIGAVRTPGRQPLRRAMRLLDVIALAGGLAEDSSRFVNVIRYVSKPAEEAQPALGAAPTPEPDEDVPPDVEILSINIDDIIAGNAKNNLLLQPGDIISVPRADVVYLAGNVRKPGPITARNPITVTQAIAMASGLAEGAKRNDIRLYRTVPGKLEREEIKISLAAIQSGKQKDLVLQANDVLYVPHSELRSAGTTVMRSLPTLVTSALIPLLTTAIIR
>NC_016025.1|WP_014101553.1|988823_989063_-|hypothetical-protein
MLRFTETLQRFQQGCFFQGRKSLTIHRSLFCRFDEAAFFKAENGVASRLQLIFILLPFGVGSILFFSPEVPPFPVLSVP
>NC_016025.1|WP_014101554.1|989086_991162_-|FHA-domain-containing-protein
MEFPKLIVTGPTASQRVDECRKFPLVIGRATTCDVIVADERASRSHARIEVSPDGNYQLVDLGSRNGTLLNGKLVTQPTFLKDGDSIGIGSHTLVFRLPAPATIRYDDAPITGTVRLQKAATLLALGLSGDVTGKPSGSFRAVAPPPAQSILVRAEELHLLKKRSQMLSLFYDFNKRVAREFDKAAIYAEVARQVFEISNAGRLLIGKRGLDDQPMIEWATYRDDVTRAAYGKMPVSRSVIRKVMQERVSLLSRDMTDVKGTAILGIQSLMCVPMLGQEEGPLGVIYADSLHRDGFTEDDVDYLTGLASTVALTLESLMAHERLLHEEAARTAYRRFLPPHVVDQIMQDPDSLQLGGTNQVVTTLFADIRGFTTLSERKSPQEIVAILNNYFERAATAIFRHGGSLDKFIGDGIMALFGAPQPSERDPINAVQAAIALQEVIEQVNADLEAQGSDLRLSIGIGINTGEVTAGYIGSRQRTDYTVIGDAVNLAARLESNAKPGQILIGETTARCLKALLQTGFEFGEEEQEFAFVPLGGLKVKGKLQEVNVYRVLWGQELVALKGEGKTDGSGDQTFFHSAARDPVVESETILRTGLGGTAVQREPRRKLTVRVVVAGTDLSGRSFEQETETVDVSQSGACVRLAQPMAIPSPLTISVPDYGWQGEAIVRTIARDTHGYLTGIEIIGQSPRW
>NC_016025.1|WP_187288462.1|991254_991968_-|3',5'-cyclic-nucleotide-phosphodiesterase
MITFLVNDCVAIDAGALAFHLTGEALLAVQDIVLTHVHLDHIASLPFIFSEMFSSIRTPVRIHATVADIERLRCHIFNDVIWPDFTRLRNVHGELLTFVPFTWRDPFEVAGLRLTAIPVTHTVETAGLVVEDGQGRCVAFTSDTGVTDEFWEVLNALPRLDAVFVDVAFDNANEFVAKASYHLSPRLLVGELAKLRRPSQVLAVNLKPFCREQVKDEVRALALPNVQVAELDVDYTW
>NC_016025.1|WP_014101556.1|992911_994588_+|replication-initiator-protein-A
MAEKRGRRKKRETDIPEGSPTAAGATSATAATAAEADDAEKPEVIRIAQDEFNLAVFPIAVLDKRAQKSKNYLTFTEHITSNGREIQRVWTVMPHPIEGLPSTTDEDVYVALMELSYEQGAQKKVYFSRYDLIRRLGWPMNAKHYERLESSLRKLAAVRIEAKNAYVDRHTGRLVDVGMSIIQEFKIFDEGAGKRTGAKSYVMWSDRVAQSLSEKLFKKLDADFYFNLTSPIAKRLFRYLDKKFGSSDYFVINVRKLAFEHVGMSREMTYVSQIMQRLEPALNELVAKQFLVEWTLTEETIHFRKNLEFGARIQQMALPIYDVMDAMCDDDLSPEERAVRDVALHLEGQLTARGMIGSVAKKLVESFELQGKLETIEQAIATFDRQYRQRDLANPGGLLYTLIVNGQEALPKLPPKRRRSSAKMPRARAEKPAEASESTGETRDSHEAVPLFSTPSQEQMQELELGYLEHLERTGEALLAQLKKSELKELVAREREELLASDRRKIYARWEPDVLDEHLRRLVGRKLAEAKVESFAAWCAARGVELNALMRPSTTSED
>NC_016025.1|WP_014101557.1|994653_996573_-|response-regulator
MSAKVLISEDDPASRKLLQVWLSQDGYEVTSVDNGKAALEAARRVLPDVVLSDVMMPEMDGFALCRELRADPCLGEIPIVLVTALSDKAARLQGIEAGADDFLTKPYDQAELRARVRSIVRLNRYRLLLQEREQRAAERARAAARLKELAELLDQTQDAVVQIDRQGHITFWSAGAARMFGWLSEEAQGQPAANLLFPQSGQLPLDALTSVVQEGYWTGELTTHRRDGREIILMTRWSAVTRSEDGARSTLLIATDITEQRQAERRYLRAQRMETIGMLASGVAHDLNNMLTPIGIGLEILRREIQNPALTEVLNMMNSSVERGAALVKQVLSLAREGSGAASLVQPKHILREVASIARETFPKNITVRTDYPAALRTIAGDPTELTQVLLNLCVNARDAMPQGGTLTLAARDLPAEEATRLHPHQTTSGESEYYVLLEVTDTGTGIPPELRERIFEPFFTTKPQGKGTGLGLATVVSIVNKRGGFIALDSEVGRGTTFRLYFPATEAPEVPSTPPEQGVSGQGELVLVADAEASTLDLLRTVLEANGYTVITARDDAELATGLARHPAVAIIDAALPTVMQSHSVFASLPADLPLIGICGEDAETCRRRTEHLPVRAWLNKPFTASQVLRALREILKA
>NC_016025.1|WP_014101558.1|996610_997198_-|ferritin-like-domain-containing-protein
MSSNDAEIHGSLRALALPRRAVLHMGFVAGISAGLGHLAEAAQRSPRNADVALLNAALALEHQAIAAYDAGVGTGLLKGETLELARHFQSQHRAHRDLLVGEIRKLGGTPAVALASYTFKGKDDAPIEFRTAEDVLVFALGLEGGAASAYLGLLPQLTSRAMLSTIAGIACDEAQHVAAIRLLMRQQPAPDAVVR
>NC_016025.1|WP_014101559.1|997194_997524_-|hypothetical-protein
MKLFSTTRTVHYDAATKALAQAVGRCPDDADRRKDFRAALAEAERAHRLAAHAERTLEIIVQSALALGDKDRAKAALDRLAAVNPGNPRLAELARALAAATPTMKERPS
>NC_016025.1|WP_041570041.1|997520_998288_-|hypothetical-protein
MNHKPWQSIFDTYKIHKHNFSQSPFTLTAEQIKKATAHFTSTTEREVRVLCKQDTRESRPQVFVDNNLFILPIKNGVYSILQGEGYIDVPEIATQATIYKSRLDFELNTSKVGNSEMQHLDFAYSSSLIRHFLEDESLVLTIRGRKYTPKFEFYAGQHKHLITAEGVQTEVDAGYEGRNQVVLIEAKNRSTTNTIIRQLYYPFRQWQIHTKKKVNVLFFEKRQNEYALWQFDFDDEKDYNSIKLLKSAQFEIESR
>NC_016025.1|WP_014101561.1|998256_999207_-|DNA-adenine-methylase
MIMTRARPFIKWVGGKSQLLEQFENFYPDELRKGIIKNYVEPFLGGGALFFALSQRYKIESAYLSDLNKDLILTYQVIQQRPNDLLDFLEQYQKDYDQTETEKRKDLFLAVRRHFNLQRFEINYKKLSDNWIPRAAQFIFLNKTCFNGLFRLNSRGEFNVPYGKYKTAVIFDEPNILAVSKVLQRAEIQQADYTSCFDKVNENTFVYLDPPYRPISQTASFTTYTGAEFDDKEQLQLAQFFRKLDQETGAKLMLSNSDPKNENPKDDFFEKAYSGYNIFRVSASRAVNCNGEKRGKINELLITNYQYEPQTLAINF
>NC_016025.1|WP_148264142.1|999210_999975_-|tetratricopeptide-repeat-protein
MSTASFKTFVLGLVVGALGGYGLGHWLPLGGAAGAGASPPAPAGRPAATAVAPPLTPDQSRGALPATHPPLTTAGGPSASPAVRAACQSADADPGNYLAQMDAAAALYRAGNFAGALDYAQRARHLRPDSVDALLAVGVSQAELEQYDAAAKTLAQAVERRPDDADIRTELAYVHLRRKDFRAALAEAERAHRLAAHAERTLEIIVQSALALGEKARAKAALDRLAAVNPGNPRLAELARALAAATPTAKGKPS

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_016025_2	2.78\|426509\|34\|NC_016025\|CRISPRCasFinder,CRT,PILER-CR	426509-426542	34	NC_022052	Mycobacterium phage Whirlwind, complete genome	48143-48176	7	0.794
NC_016025_2	2.78\|426509\|34\|NC_016025\|CRISPRCasFinder,CRT,PILER-CR	426509-426542	34	NZ_CP015748	Shinella sp. HZN7 plasmid pShin-12, complete sequence	47174-47207	8	0.765
NC_016025_2	2.56\|424926\|34\|NC_016025\|CRISPRCasFinder,CRT	424926-424959	34	NZ_CP015322	Mesorhizobium amorphae CCNWGS0123 plasmid pM0123d, complete sequence	252276-252309	9	0.735
NC_016025_2	2.93\|427579\|36\|NC_016025\|CRISPRCasFinder,CRT,PILER-CR	427579-427614	36	NZ_CP039924	Agrobacterium tumefaciens strain CFBP7129 plasmid pAtCFBP7129a, complete sequence	446903-446938	9	0.75
NC_016025_4	4.52\|988559\|33\|NC_016025\|CRT	988559-988591	33	MH892361	Streptococcus phage SW12, complete genome	24297-24329	9	0.727
NC_016025_2	2.41\|423852\|34\|NC_016025\|PILER-CR,CRISPRCasFinder,CRT	423852-423885	34	NC_017508	Marinobacter adhaerens HP15 plasmid pHP-42, complete sequence	6231-6264	10	0.706
NC_016025_2	2.41\|423852\|34\|NC_016025\|PILER-CR,CRISPRCasFinder,CRT	423852-423885	34	NZ_CP044223	Nitrincola sp. KXZD1103 plasmid unnamed1, complete sequence	13406-13439	10	0.706
NC_016025_2	2.85\|427011\|34\|NC_016025\|CRISPRCasFinder,CRT,PILER-CR	427011-427044	34	NZ_AP022602	Mycobacterium gallinarum strain JCM 6399 plasmid pJCM6399	162920-162953	10	0.706
NC_016025_4	4.52\|988559\|33\|NC_016025\|CRT	988559-988591	33	MH937494	Streptococcus phage CHPC1042, complete genome	24484-24516	10	0.697
NC_016025_4	4.52\|988559\|33\|NC_016025\|CRT	988559-988591	33	FJ965538	Streptococcus phage 5093, complete genome	29723-29755	10	0.697
NC_016025_2	2.16\|422055\|34\|NC_016025\|PILER-CR,CRISPRCasFinder,CRT	422055-422088	34	NZ_CP028186	Campylobacter jejuni strain CFSAN054107 plasmid pGMI16-002, complete sequence	63465-63498	11	0.676
NC_016025_2	2.66\|425640\|34\|NC_016025\|CRISPRCasFinder,CRT,PILER-CR	425640-425673	34	NZ_CP054028	Rhizobium sp. JKLM19E plasmid pPR19E01, complete sequence	31853-31886	11	0.676
NC_016025_4	4.39\|987675\|35\|NC_016025\|PILER-CR,CRISPRCasFinder,CRT	987675-987709	35	MF403007	Agrobacterium phage Atu_ph04, complete genome	104936-104970	11	0.686
NC_016025_4	4.52\|988559\|33\|NC_016025\|CRT	988559-988591	33	MH892371	Streptococcus phage SW25, complete genome	19112-19144	11	0.667
NC_016025_4	4.52\|988559\|33\|NC_016025\|CRT	988559-988591	33	KU678389	Streptococcus virus 9871, complete genome	19588-19620	11	0.667
NC_016025_4	4.52\|988559\|33\|NC_016025\|CRT	988559-988591	33	MH892374	Streptococcus phage SW28, complete genome	19674-19706	11	0.667
NC_016025_4	4.52\|988559\|33\|NC_016025\|CRT	988559-988591	33	KU678391	Streptococcus virus 9873, complete genome	20155-20187	11	0.667
NC_016025_4	4.52\|988559\|33\|NC_016025\|CRT	988559-988591	33	MH892369	Streptococcus phage SW22, complete genome	19109-19141	11	0.667
NC_016025_4	4.52\|988559\|33\|NC_016025\|CRT	988559-988591	33	FJ226752	Streptococcus phage ALQ13.2, complete genome	23966-23998	11	0.667
NC_016025_4	4.52\|988559\|33\|NC_016025\|CRT	988559-988591	33	NC_031094	Streptococcus virus 9872, complete genome	20155-20187	11	0.667
NC_016025_4	4.52\|988559\|33\|NC_016025\|CRT	988559-988591	33	MH892370	Streptococcus phage SW23, complete genome	19109-19141	11	0.667

1. spacer 2.78|426509|34|NC_016025|CRISPRCasFinder,CRT,PILER-CR matches to NC_022052 (Mycobacterium phage Whirlwind, complete genome) position: , mismatch: 7, identity: 0.794

gcagttgcaccgccgccgagaaaacttgcggctt-	CRISPR spacer
gcagatgcatcgccgccgagaaaatct-cgccgtg	Protospacer
**** ****.**************..* ** * *

2. spacer 2.78|426509|34|NC_016025|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP015748 (Shinella sp. HZN7 plasmid pShin-12, complete sequence) position: , mismatch: 8, identity: 0.765

gcagttgcaccgccgccgagaaaacttgcggctt	CRISPR spacer
ccaatgacaccgccgccgataaaaattgcggcaa	Protospacer
 **.* .************ **** *******

3. spacer 2.56|424926|34|NC_016025|CRISPRCasFinder,CRT matches to NZ_CP015322 (Mesorhizobium amorphae CCNWGS0123 plasmid pM0123d, complete sequence) position: , mismatch: 9, identity: 0.735

accgcgccggtttttccgtttgagccaaactggg	CRISPR spacer
accggggcggtttttccgtttgagaggaacgcaa	Protospacer
**** * *****************  .***  ..

4. spacer 2.93|427579|36|NC_016025|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP039924 (Agrobacterium tumefaciens strain CFBP7129 plasmid pAtCFBP7129a, complete sequence) position: , mismatch: 9, identity: 0.75

tccgacaagccaattggcgcggtcaaacgcaggtca	CRISPR spacer
tcgccgaaggcaattggcgcggtcaaatgcagtccc	Protospacer
**    *** *****************.**** .*

5. spacer 4.52|988559|33|NC_016025|CRT matches to MH892361 (Streptococcus phage SW12, complete genome) position: , mismatch: 9, identity: 0.727

cgatgcttgacaagacaaccaaactgtgccaaa	CRISPR spacer
cttgttccaacaagacaaccaaactgtaccaaa	Protospacer
*    ....******************.*****

6. spacer 2.41|423852|34|NC_016025|PILER-CR,CRISPRCasFinder,CRT matches to NC_017508 (Marinobacter adhaerens HP15 plasmid pHP-42, complete sequence) position: , mismatch: 10, identity: 0.706

aacgttttgtcaaggggaaagttccgattttttt	CRISPR spacer
cctatcttgtcaagcggaaaattccgatttatcg	Protospacer
  ..*.******** *****.********* *.

7. spacer 2.41|423852|34|NC_016025|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP044223 (Nitrincola sp. KXZD1103 plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.706

aacgttttgtcaaggggaaagttccgattttttt	CRISPR spacer
cctatcttgtcaagcggaaaattccgatttatcg	Protospacer
  ..*.******** *****.********* *.

8. spacer 2.85|427011|34|NC_016025|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP022602 (Mycobacterium gallinarum strain JCM 6399 plasmid pJCM6399) position: , mismatch: 10, identity: 0.706

ggccgcatcctgtactcgccgtcaatgccgggcc	CRISPR spacer
atccgcaccccgtactcgccgtcaatcaggtaac	Protospacer
. *****.**.***************   * . *

9. spacer 4.52|988559|33|NC_016025|CRT matches to MH937494 (Streptococcus phage CHPC1042, complete genome) position: , mismatch: 10, identity: 0.697

cgatgcttgacaagacaaccaaactgtgccaaa	CRISPR spacer
cttgttccaacaagacaaccaaactgtaccgaa	Protospacer
*    ....******************.**.**

10. spacer 4.52|988559|33|NC_016025|CRT matches to FJ965538 (Streptococcus phage 5093, complete genome) position: , mismatch: 10, identity: 0.697

cgatgcttgacaagacaaccaaactgtgccaaa	CRISPR spacer
tttatcccaacaagataaccaaactgtgccgaa	Protospacer
.    *...******.**************.**

11. spacer 2.16|422055|34|NC_016025|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP028186 (Campylobacter jejuni strain CFSAN054107 plasmid pGMI16-002, complete sequence) position: , mismatch: 11, identity: 0.676

caggggttgcccttgtgttgcacaaaccagtcgt	CRISPR spacer
gccgggttgcccttgtgtttctcaaaccgcaaaa	Protospacer
   **************** * ******.   .

12. spacer 2.66|425640|34|NC_016025|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP054028 (Rhizobium sp. JKLM19E plasmid pPR19E01, complete sequence) position: , mismatch: 11, identity: 0.676

tacgggagacggcgcagaagctcccctaaagcgt	CRISPR spacer
accgggagacggcggagaagctcgccgctgagtt	Protospacer
  ************ ******** **   ..  *

13. spacer 4.39|987675|35|NC_016025|PILER-CR,CRISPRCasFinder,CRT matches to MF403007 (Agrobacterium phage Atu_ph04, complete genome) position: , mismatch: 11, identity: 0.686

taaatccggtcgtcgtccttgcacacggcgtagta	CRISPR spacer
acggttcggtcgtcgttcttgaacacggcgtcagg	Protospacer
  ..*.**********.**** ********* . .

14. spacer 4.52|988559|33|NC_016025|CRT matches to MH892371 (Streptococcus phage SW25, complete genome) position: , mismatch: 11, identity: 0.667

cgatgcttgacaagacaaccaaactgtgccaaa	CRISPR spacer
tttattccaacaagacaaccaaaccgtaccaaa	Protospacer
.    ....***************.**.*****

15. spacer 4.52|988559|33|NC_016025|CRT matches to KU678389 (Streptococcus virus 9871, complete genome) position: , mismatch: 11, identity: 0.667

cgatgcttgacaagacaaccaaactgtgccaaa	CRISPR spacer
tttattccaacaagacaaccaaaccgtaccaaa	Protospacer
.    ....***************.**.*****

16. spacer 4.52|988559|33|NC_016025|CRT matches to MH892374 (Streptococcus phage SW28, complete genome) position: , mismatch: 11, identity: 0.667

cgatgcttgacaagacaaccaaactgtgccaaa	CRISPR spacer
tttattccaacaagacaaccaaaccgtaccaaa	Protospacer
.    ....***************.**.*****

17. spacer 4.52|988559|33|NC_016025|CRT matches to KU678391 (Streptococcus virus 9873, complete genome) position: , mismatch: 11, identity: 0.667

cgatgcttgacaagacaaccaaactgtgccaaa	CRISPR spacer
tttattccaacaagacaaccaaaccgtaccaaa	Protospacer
.    ....***************.**.*****

18. spacer 4.52|988559|33|NC_016025|CRT matches to MH892369 (Streptococcus phage SW22, complete genome) position: , mismatch: 11, identity: 0.667

cgatgcttgacaagacaaccaaactgtgccaaa	CRISPR spacer
tttattccaacaagacaaccaaaccgtaccaaa	Protospacer
.    ....***************.**.*****

19. spacer 4.52|988559|33|NC_016025|CRT matches to FJ226752 (Streptococcus phage ALQ13.2, complete genome) position: , mismatch: 11, identity: 0.667

cgatgcttgacaagacaaccaaactgtgccaaa	CRISPR spacer
tttattccaacaagacaaccaaactgtaccgaa	Protospacer
.    ....******************.**.**

20. spacer 4.52|988559|33|NC_016025|CRT matches to NC_031094 (Streptococcus virus 9872, complete genome) position: , mismatch: 11, identity: 0.667

cgatgcttgacaagacaaccaaactgtgccaaa	CRISPR spacer
tttattccaacaagacaaccaaaccgtaccaaa	Protospacer
.    ....***************.**.*****

21. spacer 4.52|988559|33|NC_016025|CRT matches to MH892370 (Streptococcus phage SW23, complete genome) position: , mismatch: 11, identity: 0.667

cgatgcttgacaagacaaccaaactgtgccaaa	CRISPR spacer
tttattccaacaagacaaccaaaccgtaccaaa	Protospacer
.    ....***************.**.*****

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NC_016024

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NC_016024_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016024_1

121694-121788

Unclear

Consensus_repeat	Method
TGATTGAACAGCGCGGCTTCCCA	CRISPRCasFinder

1 spacers

cas3,csb1gr7,csb2gr5

The CRISPR arrays of NC_016024_1

>merge|NC_016024|1|121694-121788|CRISPRCasFinder
TGATTGAACAGCGCGGCTTCCCAAAAGACGGCAAGCAAGGGCGCGGGGGCGCGCCTACCTTGGAAGTCCTCGAGATTGAACAGCGCGGCTTCCCA

>NC_016024|1|1|121694-121788|CRISPRCasFinder
TGATTGAACAGCGCGGCTTCCCA	AAAGACGGCAAGCAAGGGCGCGGGGGCGCGCCTACCTTGGAAGTCCTCG
AGATTGAACAGCGCGGCTTCCCA

Protein	Signature genes	Signature genes Name	Protein_function
NC_016024.1\|WP_014098620.1\|133313_134186_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|212492
NC_016024.1\|WP_014098603.1\|110749_112291_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|131777
NC_016024.1\|WP_014098618.1\|131022_131655_-\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|275145
NC_016024.1\|WP_049787435.1\|131722_133210_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|133045
NC_016024.1\|WP_041569021.1\|109152_110112_-\|oxygen-dependent-coproporphyrinogen-oxidase	unknown	unknown	gnl\|CDD\|376494
NC_016024.1\|WP_014098608.1\|116681_117401_+\|Bax-inhibitor-1/YccA-family-protein	unknown	unknown	gnl\|CDD\|198414
NC_016024.1\|WP_148264046.1\|117752_120620_+\|DEAD/DEAH-box-helicase	cas3	cd09696_cas3_CAS-I-U	gnl\|CDD\|274235
NC_016024.1\|WP_014098614.1\|127453_128218_+\|TIGR00266-family-protein	unknown	unknown	gnl\|CDD\|376704
NC_016024.1\|WP_014098602.1\|110225_110753_+\|hypothetical-protein	unknown	unknown	unknown
NC_016024.1\|WP_014098607.1\|115325_116543_-\|class-I-SAM-dependent-rRNA-methyltransferase	unknown	unknown	gnl\|CDD\|224017
NC_016024.1\|WP_014098606.1\|114069_115260_+\|DNA-polymerase-III-subunit-beta	unknown	unknown	gnl\|CDD\|235541
NC_016024.1\|WP_014098611.1\|122812_123955_+\|CRISPR-associated-protein	csb1gr7	pfam09617_csb1gr7_CAS-I-U	gnl\|CDD\|378223
NC_016024.1\|WP_014098617.1\|129430_130870_-\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173799
NC_016024.1\|WP_014098615.1\|128248_128698_-\|cytidine-deaminase	unknown	unknown	gnl\|CDD\|180142
NC_016024.1\|WP_148264047.1\|123957_125478_+\|type-I-U-CRISPR-associated-protein-Cas5/Cas6	csb2gr5	cls000315_csb2gr5_CAS-I-U	gnl\|CDD\|274005
NC_016024.1\|WP_014098616.1\|128694_129330_-\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl\|CDD\|153251
NC_016024.1\|WP_014098604.1\|112386_113124_+\|phosphoribosylformylglycinamidine-synthase-subunit-PurQ	unknown	unknown	gnl\|CDD\|235140
NC_016024.1\|WP_014098613.1\|125647_127363_+\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|223395
NC_016024.1\|WP_148264045.1\|107998_109105_+\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|368185
NC_016024.1\|WP_014098605.1\|113101_113959_-\|carboxylating-nicotinate-nucleotide-diphosphorylase	unknown	unknown	gnl\|CDD\|238806

Protein	Function_ID	Function_description	E-value
NC_016024.1\|WP_014098620.1\|133313_134186_-\|SDR-family-oxidoreductase	gnl\|CDD\|212492	cd05327, retinol-DH_like_SDR_c_like, retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs. Classical SDR subgroup containing retinol-DHs, LPORs, and related proteins. Retinol is processed by a medium chain alcohol dehydrogenase followed by retinol-DHs. Pchlide reductases act in chlorophyll biosynthesis. There are distinct enzymes that catalyze Pchlide reduction in light or dark conditions. Light-dependent reduction is via an NADP-dependent SDR, LPOR. Proteins in this subfamily share the glycine-rich NAD-binding motif of the classical SDRs, have a partial match to the canonical active site tetrad, but lack the typical active site Ser. This subgroup includes the human proteins: retinol dehydrogenase -12, -13 ,and -14, dehydrogenase/reductase SDR family member (DHRS)-12 , -13 and -X (a DHRS on chromosome X), and WWOX (WW domain-containing oxidoreductase), as well as a Neurospora crassa SDR encoded by the blue light inducible bli-4 gene. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	2.86251e-109
NC_016024.1\|WP_014098603.1\|110749_112291_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|131777	TIGR02730, Carotenoid_isomerase, carotene isomerase. Members of this family, including sll0033 (crtH) of Synechocystis sp. PCC 6803, catalyze a cis-trans isomerization of carotenes to the all-trans lycopene, a reaction that can also occur non-enzymatically in light through photoisomerization. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	9.60111e-173
NC_016024.1\|WP_049787435.1\|131722_133210_-\|glycosyltransferase	gnl\|CDD\|133045	cd06423, CESA_like, CESA_like is the cellulose synthase superfamily. The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.	5.63597e-19
NC_016024.1\|WP_041569021.1\|109152_110112_-\|oxygen-dependent-coproporphyrinogen-oxidase	gnl\|CDD\|376494	pfam01218, Coprogen_oxidas, Coproporphyrinogen III oxidase.	0
NC_016024.1\|WP_014098608.1\|116681_117401_+\|Bax-inhibitor-1/YccA-family-protein	gnl\|CDD\|198414	cd10432, BI-1-like_bacterial, Bacterial BAX inhibitor (BI)-1/YccA-like proteins. This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.	1.7863e-43
NC_016024.1\|WP_148264046.1\|117752_120620_+\|DEAD/DEAH-box-helicase	gnl\|CDD\|274235	TIGR02621, CRISPR-associated_helicase_Cas3, CRISPR-associated helicase Cas3, subtype Dpsyc. This model describes a CRISPR-associated putative DEAH-box helicase, or Cas3, of a subtype found in Actinomyces naeslundii MG1, Geobacter sulfurreducens PCA, Gemmata obscuriglobus UQM 2246, and Desulfotalea psychrophila. This protein includes both DEAH and HD motifs.	6.45401e-40
NC_016024.1\|WP_014098614.1\|127453_128218_+\|TIGR00266-family-protein	gnl\|CDD\|376704	pfam01987, AIM24, Mitochondrial biogenesis AIM24. In eukaryotes, this domain is involved in mitochondrial biogenesis. Its function in prokaryotes in unknown.	5.43509e-79
NC_016024.1\|WP_014098618.1\|131022_131655_-\|radical-SAM-protein	gnl\|CDD\|275145	TIGR04349, Radical_SAM_domain_protein, putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type. Members of this radical SAM domain protein family appear to be a form of the queuosine biosynthesis protein QueE. QueE is involved in making preQ0 (7-cyano-7-deazaquanine), a precursor of both the bacterial/eukaryotic modified tRNA base queuosine and the archaeal modified base archaeosine. Members occur in preQ0 operons species that lack members of related protein family TIGR03365.	5.36082e-104
NC_016024.1\|WP_014098607.1\|115325_116543_-\|class-I-SAM-dependent-rRNA-methyltransferase	gnl\|CDD\|224017	COG1092, COG1092, Predicted SAM-dependent methyltransferases [General function prediction only].	1.25335e-117
NC_016024.1\|WP_014098606.1\|114069_115260_+\|DNA-polymerase-III-subunit-beta	gnl\|CDD\|235541	PRK05643, PRK05643, DNA polymerase III subunit beta; Validated.	1.45296e-122
NC_016024.1\|WP_014098611.1\|122812_123955_+\|CRISPR-associated-protein	gnl\|CDD\|378223	pfam09617, Cas_GSU0053, CRISPR-associated protein GSU0053 (Cas_GSU0053). This entry is found in CRISPR-associated (cas) proteins in the genomes of Geobacter sulfurreducens PCA and Desulfotalea psychrophila LSv54 (both Desulfobacterales from the Deltaproteobacteria), Gemmata obscuriglobus (a Planctomycete), and Actinomyces naeslundii MG1 (Actinobacteria).	2.97849e-45
NC_016024.1\|WP_014098617.1\|129430_130870_-\|S8-family-serine-peptidase	gnl\|CDD\|173799	cd07473, Peptidases_S8_Subtilisin_like, Peptidase S8 family domain in Subtilisin-like proteins. This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	1.61408e-154
NC_016024.1\|WP_014098615.1\|128248_128698_-\|cytidine-deaminase	gnl\|CDD\|180142	PRK05578, PRK05578, cytidine deaminase; Validated.	9.0667e-50
NC_016024.1\|WP_148264045.1\|107998_109105_+\|amidohydrolase-family-protein	gnl\|CDD\|368185	pfam04909, Amidohydro_2, Amidohydrolase. These proteins are amidohydrolases that are related to pfam01979.	3.68142e-35
NC_016024.1\|WP_014098616.1\|128694_129330_-\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl\|CDD\|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	5.14166e-51
NC_016024.1\|WP_014098604.1\|112386_113124_+\|phosphoribosylformylglycinamidine-synthase-subunit-PurQ	gnl\|CDD\|235140	PRK03619, PRK03619, phosphoribosylformylglycinamidine synthase subunit PurQ.	1.56365e-150
NC_016024.1\|WP_014098613.1\|125647_127363_+\|AMP-binding-protein	gnl\|CDD\|223395	COG0318, CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	1.07222e-102
NC_016024.1\|WP_148264047.1\|123957_125478_+\|type-I-U-CRISPR-associated-protein-Cas5/Cas6	gnl\|CDD\|274005	TIGR02165, CRISPR-associated_protein_GSU0054_family, CRISPR-associated protein GSU0054/csb2, Dpsyc system. This model represents a CRISPR-associated protein from the Dpsyc subtype (a type I-C variant), named for Desulfotalea psychrophila LSv54. CRISPR systems confer resistance in prokaryotes to invasive DNA or RNA, including phage and plasmids. CRISPR-associated proteins typically are found near CRISPR repeats and other CRISPR-associated proteins, have low levels of sequence identify, have sequence relationships that suggest lateral transfer, and show some sequence similarity to DNA-active proteins such as helicases and repair proteins.	5.19149e-24
NC_016024.1\|WP_014098605.1\|113101_113959_-\|carboxylating-nicotinate-nucleotide-diphosphorylase	gnl\|CDD\|238806	cd01572, QPRTase, Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to produce nicotinic acid mononucleotide (NAMN), pyrophosphate and carbon dioxide. QPRTase functions as a homodimer with two active sites, each formed by the C-terminal region of one subunit and the N-terminal region of the other.	9.02562e-140

>NC_016024.1|WP_148264046.1|117752_120620_+|DEAD/DEAH-box-helicase
MSNSREESFTKFFERATAGLTPATAGLTPATAGLTPYKWQTLIATEGLPDVLTVHTGLGKTEVVLAWAWRLLVDGQPEPRHLVYCLPMRSLVTQTVKRLKDYFDSLKQACPFFDVKVYQLMGGAIDDEWASQPDKPWVLVGTQDQLLSRALNRGYAMRRFDWPVHFGLLNNDCRWLIDEVQLMGPGLWTTSQLDWMRRKRFPSLKPCLTTWMSATIGTSFLSTTDRVADCLDKPSQEQDAFEKKLKAALDGDPALQWWREAKRPLAWWQPDTAEPKTGKGKKQSPAKSATPATVTPENIATFVMKNHVAGKLTLVICNTVELAQDVFRQLDVKHKVEHKVLLTSRFRGEDRSQHEQRLMEFDAKRKTGNLPPNDPGLICVSTQVIEAGIDISAHRLFTELAPWPSMLQRLGRLNRKGDDQGARGWVWETPEKGGNNERIGPYEAADIELAKMLVDAFAPLSEKAFSKAIEELNKTKKNEVTEALKPKLSPLPRALDVHGLFSTERDVHGGFTDVSAFVRGTDPDLDVMVFWRDWSGEHPPSGDDLDGPLLKPAKEGCPVSFIRVQEFLKTSQGQAWLWNDETGCWEPISPESIRPGMLLMLKRDVGGYDETEGWTGNTSNVLANVPRAGRIATLGDDTRTEAGYWSKLTDHLEDAKREAEELCNAICLQGDLRKAVVEAAALHDLGKAHPQWQNRLPTRAVIPGKLLAKCPRVVAADVAGDASAVRSEFAKLRPEAYALPDEQCRRGREEVLRLRWAIDDKLREDELKSLRSVPGVRWAGHIPFRPGLRHEAASALAMWRKYRNSEPKPYPALAVYLAAAHHGKVRTVMRSTTEEGDDVFGIRSEPGSLVIECEHWLLDFSVTKDGAEGRWEGEEGKEEFVMTGPGWTGLVTDLLGPWRPEEKSDAGAVPQGEPMDLGPFALAYLEALVRIADWRASDPSRATGAVKPSEVRNGC
>NC_016024.1|WP_014098608.1|116681_117401_+|Bax-inhibitor-1/YccA-family-protein
MNDYRYNQLDRGVPPAYGFGGVLAADASVAARMAFIRKVYALFLGGIFCAMAGVAVSIVTGLYIAVVQYYWLALILLIGAVIGVGALRRVKGVNLVALFAFTFLEGVLISPLILFTLGRSPLTLLAAGALTVATFGGLMAYTFVTRKDFSFLGGFLFTGLIVILVASLIGIFVGSSIFSLAISSGAVLLFAGYVLYDTSNIMHNLPTDEYVAGALSLFLDFFGLFIHLLNILNILGGDE
>NC_016024.1|WP_014098607.1|115325_116543_-|class-I-SAM-dependent-rRNA-methyltransferase
MPNSTRSLQPQSTGSLPTLKLHANREKSVRNRHPWIFSGAIAHWPQNLEDGGLAAVSAANGERLGYAYVNRRCSIAARMIAFGETAPYTALRDHLTRAVAFRREHFNPDQTNAVRLVNGEGDMLPGLIVDQYADVLVMQVSTLGMERLKPFVLETLVELTQPRAVYEKSDVAARYEEGLTDFAGLLYGRDFGPLVVTEQGLRFHVDIKHGQKTGLFLDQREMRALVQSLAAGRQVLNGFAYTGGFSLYAHRGRARRVVSVDSSGGALRLAQGNHILNGFSVTDDDFVEADMFAYLRQLDAAAFDFIILDPPALARKREDVIRAGRAYKDLNRLAMAKVAPGGLVLTCSCSHFVDEKLFGQIVFQAACEAGRHVRILHRHRQALDHPVSVFHPEGSYLKSLLLSVD
>NC_016024.1|WP_014098606.1|114069_115260_+|DNA-polymerase-III-subunit-beta
MEFSVAKADLLKELSFLNNVVEKKTTIPILSNILLSGEAGSAPAGNVLTLAGTDLDATLKTSCPAAIRHSGTALLPARRLFDIVRNLPDADIHFKSDGSGNMTITCERSRFRLFSPAPEGYPALPEIPALPLSVSSGILRTMIPRVLFATSQEESRYQLNGVQMVVDSAAADESQAALLRMVATDGHRLALIERPGCVQLNAGAPVEKSKVEKGKTRISFLIPKKTMAEIVRLAADTTATEIAFGQDDRHVFFQIGGRTFASRLLAGQFPNYEGVMPKSNDKIIVFETDLLVAALKRVGVVADETTHAVKLHATEGRVEITSQSPESGEAVETLSVDYPGPSMTITFNVGYLMDFLAVAHSTQTRFEFKDEITQIQLRPVDGDGYDYRYVVMPMRA
>NC_016024.1|WP_014098605.1|113101_113959_-|carboxylating-nicotinate-nucleotide-diphosphorylase
MRLDPVAIENLIAQFLAEDIGRGDVTTDAILTHEVRARGRFLAKQELILAGIEVAEMVFQWFDPEIQIQTFYLDGDTVPAGKEIARVAGPAHMLLAGERVALNLLQRMSGIATLTHAFVQAIEGTSAVIADTRKTAPGLRLLDKYAVHVGGGHNHRFGLDDGILIKDNHIALAGGIGRALRLAKKNASHLLKIEIEVSTLEQVQEAVAEGADVILLDNMTVDQVRACVALIRELEPPGRQTLVEVSGNISLDNVRAYAEAGANLISVGALTHSVKAADISLKLSP
>NC_016024.1|WP_014098604.1|112386_113124_+|phosphoribosylformylglycinamidine-synthase-subunit-PurQ
MKFGVVVFPGSNCDHDTYHVISKLIGQPVRFVWHAETSVADCDVVILPGGFSYGDYLRCGAIASCSPVMRAVREHAARGGYVVGICNGFQILCEAGLLPGVLLRNAGLRFCCDLVRVRVERADTPFTHTYAPGEVITLPIAHGEGNYYCAPEEVARLEAEGRVLFRYVDATGQPTPAANPNGSLHNIAGILNAEGNVLGLMPHPERACEEALGSSDGLRFFQALMLTLRDAEQQRRSAATVTVSG
>NC_016024.1|WP_014098603.1|110749_112291_+|FAD-dependent-oxidoreductase
MTVAHSESWQPEVVVIGSGIGGLATAARLARHGVRVLVLEQHTVPGGSASYFTRAGYRFDVGASLLYGLGTEGTINFVAEALAEVGETVETRRDDVQIHYHLPDGMEIRTHYDREHFLDELTSYFPQERAGIRAFYDAAMEAYRVMARVPLIALDDVPGLIRGVATAPWDALRMSQAALTTLGDLARRYLRDVRLRRFIDIETFCWALTGAGATPLVNAALVFGDRHVNGVRYPLGGCSVIAEKLVAGIERHGGRIRYGSRVAAGLVRQGRVQGVRLATGEDITARAVVSNATVWDTYGRLFREHPLASVMFREQSLRYAQADSFTSLFGGVASSHLPPETVVHHIVVNDWEAYDKPRGMLFVSLPSLHDASLAPPGYHNVHAFMVDRYDDWSVLTQLAAGGGGVRRTPAYRAAKEAAARHMLHMLERVIPNASEVVQVVSVGTPLTNERYLARTRGTYGPLLRRGPDVLLKPQGGSPIRGLYCAGDSCFPGQGVPSVAASGLSCAGRILRAW
>NC_016024.1|WP_014098602.1|110225_110753_+|hypothetical-protein
MFELETPTAIPETNSRRTLFLILAATFVVVSAVVGLVMWWEKQSRETAAVKMSEGMLRAGNPEYDDYLQREGIKLVTLDRLVVNGEASDRYEYICRIENRGDRPLTGIELRVYLVDMEEKIIVEKLAYPLAAQNLKQLAPGQSITARPTLTGVKTPESDVRDFLCVVNGLRFARP
>NC_016024.1|WP_041569021.1|109152_110112_-|oxygen-dependent-coproporphyrinogen-oxidase
MIATEMQSSEAPTATGPTLRERAEAFFKALQDEICSALEQLDGAARFREDLWEREGGGGGRTRVIADGRVFEKGGVNFSAVHGLMPEKLAARMMPGEDRNFYATGISLVIHPRNPMVPTVHANFRYLEQGSSTWFGGGADLTPYYPYREDVIHFHRTLKAACDEHHPDYYPRFKQWCDEYFFLPHRNETRGVSGIFFDYLKADEHTDLEAIFAFVQTAGRAFLPAYLPIVERRQPEPYGETEREFQLIRRGRYVEFNLVYDRGTVFGLETRGRTESILMSLPPLAKWLYDYRPAPGSREAEAMTYFTPQDWLGLGQATA
>NC_016024.1|WP_148264045.1|107998_109105_+|amidohydrolase-family-protein
MLRKLDLHTHILPPRWENLRAKYGYPGFPRLEYVNSRCARIIIDDRFFREVQENCWHPEARIRDCHTHGVTMQALSTVPVMFSYWAKPQDAYDLARFLNDHIAEVVARHPTYFVGLGTLPMQSPDLAARELERCVQDLGLAGVEIGTHVNDWNLDAPELFPFFQRAAELGAAVFVHPWEMVGRERMPNYFLPWLVGMPAETSLAICSMIFGGVLERLPRLRCCFAHGGGAFPFTLGRITKGWAARPDLCQVHISQPPRTYLPQIYVDSLVHDADALRYVVKVFGMTRVVLGSDYPFPLGEDEPGKLICTIEEFSDADRERLLWKNAVEFLGLDDQRLGLPSETGWPTCTESDAGAAGMPDEGVPGEPT
>NC_016024.1|WP_014098611.1|122812_123955_+|CRISPR-associated-protein
MSEKELTPADVLEGESPLVLTATFEPIGSDRFQPAGFPEIGHVIYKAPRKDGTTENVCIVDSAASMANHLERVCLRGANDLELVDELSGMPYIRCVTGDFVDDKLPNDKRKVVVTSLTEGHRIASSYFLKGYELMPNGSKAAEPFKKDLCAKFGVVLPESSKAHPPPEQWWNVFKTIFELDPNSLVHGVLFPQWQIKIPRALTAHLEAFGAGRVDRSGVKFDRLGKTTSGQPIFAVDDVTAGSIRATFVLDISLIRSFGRMKKDGDKETQLGLSENQKKFLVALALWKIKKLTEDAFRFRSDCHLRCTALGSCCGQKVSIDVDIQKAINEAGFSDQPVTDVFWPREELYREGAPEANAASTSEGDENGSPDEDDSGAEEG
>NC_016024.1|WP_148264047.1|123957_125478_+|type-I-U-CRISPR-associated-protein-Cas5/Cas6
MSVVILRQEFPLGRFHATPWRVNPFDDPYGEWPPSPWRLVRAVTARWYQWVREEGKTPDLEQLKRLQGALCKSTYRFYLPLEARKGNPLRQYQPTEFGWHPAEKRKPGKREYGRSLVQDNYWCVPPEASVWWFIEGNDWNDELKSVLEKCLERITYFGRAETLTRIRPVEQSGEIKANCQLTEQRTAGTVPVLVPCAEATREDIERTTDDPLAAKQTIPPGARWLYAKRPNPPASREHRRVPERRLECHLMQFAIGWNVAPERRAIVRLTARFRGAVIRELLLLKTKDASSSWTKTSRDVRESVADMIGKNADGEPLNGHCHTEFLVWCEDGQPTRLLVWRGSRAFDAEEQEAILLAAKRDVSWAAAGPDSDEWKVRLVPLDQAVPPPPGFDGQPSKVWESVTPYVPPRHYLRSGKVRAGESIAEQICREVRKREIAQDVQVDLLGTPQWVAVHVPPRKATERTFIGDRRGQMVRLRFDKLVVGPIRLGHSSSFGLGLFRPVEEPR
>NC_016024.1|WP_014098613.1|125647_127363_+|AMP-binding-protein
MRDLLTEFEREEIVVERLDAWAQTTPDAVYFHYGEDDRTLTFGEVAELTDRIAGNLARLGITRGQRVSLLMQNPLITTLAMFGIWKAGAVFCPINYTFTGKLLAYTLNDTQPALLLTERRMVPRLTEIAAELSQLPRTVVYDAPEGTHDFLPPTERMPLPDAFQPTGWTELLEPAARPNVTLQYTDPASIIYTSGTTGPSKGVILPFRCLNQYCFLARKLLTREDVIYCDLPMYHIAGAFALIARAAWVGCEVAVWNRFSPQDFWARIAKRGATTAILLDVMVPWLMKAPPSENDRATTLSKVHLQPLPLNHQEIARRFGFDIVTTGFGQTESGLGLCLLIEEMPEGEGTPPELWKGSNRAHLRQVAGQFGIPVVRGETVTTKGAMGRPMPFHEVAILDAKGYPCAPGEIGELCFRPKIPSLLFDGYLGKPEATLKAFRQLWFHTGDAAYVNEQGEYFFVDRLGDRLRRRGENFSSYVVEDLMHQHPDIALCAVFPIPGAESDEDDIVAFIVPKAGTALTEAAVEAWAAQHLPKFMQPQHIRLVTELPRTLTNKVEKYKLRAEVLRELGRV
>NC_016024.1|WP_014098614.1|127453_128218_+|TIGR00266-family-protein
MPQSDVIDYRIVGDDLQGVIITLDPNEQVLAEAGVMLYMTAGIEMQTTMATDSSKGFFGNLAKAVGRVFSGAGFFITTFTNYGHARADVAFAAPYPGKIIPIDLAKFGGEVLCQKDSFLCAARGTDLSVGFQQRLGAGFFGGEGFILQRLRGDGLAFIHAGGATMTYNLRPGETLRVDTGCVVAFQPSVQFNIQFVGGFKNALFGGEGLFLASLTGPGQVILQTLPFSRLVGRIAATLPRATSGGGGGFFGDEN
>NC_016024.1|WP_014098615.1|128248_128698_-|cytidine-deaminase
MSRSTPSAGCDEAVLIAAAREARRQAHAPYSGFSVGAVVQARSGKLYTGCNIENASFGLTVCAERVALFKALSEGERQFQAVVIATDATTPTPPCGACRQVLWEFCGDIRIISAGPQGKTAEWSLAALLPAAFDDRNLAATTPSSPEPD
>NC_016024.1|WP_014098616.1|128694_129330_-|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MNLHQRTIVYVTRPALRLALHPFFRMTYFGVEHVPKTGPVLLAPNHQAYADPFWIGLPIRRPIHFMTWSRVFRVAYLRPLLRYFQCFPVDHDKPFDKSALKIAQELLRAGQAVMIFPEGGRTPHGDLQEFKAGAFRIAVKLRVPIVPVTLNGGFEVWNMYRKLPRPGKITVYFHPPMYFSADDRDLKEVTAEAARAVREVIASKLQRPVAS
>NC_016024.1|WP_014098617.1|129430_130870_-|S8-family-serine-peptidase
MRPSTLKHLALGCAVIAAAGGIGLMRRLPAPKPREMKVCRIEARPSQHQVPYSASTPTVAERPESYGFIIKYKRTAKPGVISRMLEELNIRRSYRYPHLPLLAFGMYPEGEAQATDVFLERLRQHPSVEYVEPNYVYRIGDTRPDDPSFAEQWGHLNEGQPIKGGQPGIPGVDAAVVSAWDVTTGSREVVVAVIDTGVDYTHEDLADNMWVNTREIPNNGIDDDGNGIVDDYYGYNAVGNNGNPLDDNGHGTHCAGIIGAKGDNGTGIAGINWDVRLMALKFLDANGRGTLNDALECIDYAIAMKQRGVNVRVLSNSWGGGGYSRALEEAIRTANANDILFVAAAGNSGTNNDRIPHYPASYDVPNVLSVAALAPNDNLASFSCYGKKTVHLAAPGVDIYSTVPVTVFGQGYKHFSGTSMATPYVAGAAALVLARDPKLSVTALKAQLLRSVTPVAALEGRLATGGRLNIARALGVRGE
>NC_016024.1|WP_014098618.1|131022_131655_-|radical-SAM-protein
MRITEIFFSIQGESSYAGLPCAFVRTTGCDLRCTWCDSEYTFTGGTHMSVEEILERIRAYPTRLVELTGGEPLLQKDIYELAGRLLDEGYTVLIETGGHRDVSRLDPRIIKIMDIKCPGSGMVEKNLWSNLDHITRRDEVKFVLADLADYFWAREILRIYRLEQRTNVLFSTVFGVEQRPIVERLLADGLQVRFQTQLHKLIWPADMRGV
>NC_016024.1|WP_049787435.1|131722_133210_-|glycosyltransferase
MDGALPAFFIVAAPGGIGFEFKLGLKSGATALVLAVLAAALLRLVSMGSSLWEIRQRWQRRAVEMEWTLPNSERIRPISIVVVVQGGREQVVEAVDRLLALDYPRFEVIVVSDGSPDGTLTCLREAFSLHPTSRIIQKSIPVQTEPTLYASTKHPRLTVVAKPETGREDSLNCGLNVSRYPLICALDTQVTLDADALIELARGFIENVTQTVAVSCLAEFYGDASTPSGSDIRLSADGIAPMYAPMQRSVSAAADQRPLDDLQRVDRATLFHVQWLLRAGVGNLAMLPGVVSLLKKAEIVAAGGYRTGYAADTLDLLLTAYRVRKSEETRRVLFLPEVIARIAPLDSLDETMQARATATQESFGIIVRHLGLTFSGQGDWRARLALPVFIVTVLFAPVWEWMAVILVDVAALAGGFTFDELVALLTLFLSIGLADSLGGLLCDEVSNRRRRSTGEILHLSLAAITHAVTFRWMMGLAQLRGMLAYISGRSIRETM
>NC_016024.1|WP_014098620.1|133313_134186_-|SDR-family-oxidoreductase
MKRIALVTGGTSGIGKETVRGLARAGLAVVLVGRDQRKCAEVVQELRADTGQTDITALTADLSRLEDIRRVADEFRATYPRLDVLVNNVGAIFDTRRTTPDGLEQTFALNHISYFLLTNLLLDRLLASAPARVVNVSSAAHRFVPGVDFDDLQFERKPYAPMTAYGQSKLMNILFSQELARRLEGTGVTSNSLHPGGVASNFADNTTGWFRLTAKVLKWAVGISPARGAETSVYLATSDEVAGVSGRYFERCRAATTSAAAMDPTAQVRLWQVSEQVVGQVFPSPAGVTS

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Crispr_ID: NC_016024_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016024_2

240746-240928

Orphan

Consensus_repeat	Method
CGTACGGGCAACCCCCCGTGGTTGCCCCGATC	PILER-CR

2 spacers

The CRISPR arrays of NC_016024_2

>merge|NC_016024|2|240746-240928|PILER-CR
CAACCCCCCGTGGTTGCCCCGATGAAATGAATGCAACCCCCCGCGTCCACCCCGACGAAATGAACGTAAACGTAGGGGCAACCCCCCGTGGTTGCCCCGATCATCCCCGTGATTGCCCCGATCATCCCCGTGATTGCCCCGATGAAATGGCCGTACGGGCAACCCCCCGTGGTTGCCCCGATC

>NC_016024|2|1|240746-240928|PILER-CR
CAACCCCCCGTGGTTGCCCCGATGAAATGAAT	GCAACCCCCCGCGTCCACCCCGACGAAATGAACGTAAACGTAGGGG
CAACCCCCCGTGGTTGCCCCGATCATCCCCGT	GATTGCCCCGATCATCCCCGTGATTGCCCCGATGAAATGGCCGTACGGG
CAACCCCCCGTGGTTGCCCCGATC

Protein	Signature genes	Signature genes Name	Protein_function
NC_016024.1\|WP_148263877.1\|232511_232772_+\|hypothetical-protein	unknown	unknown	unknown
NC_016024.1\|WP_014098715.1\|252076_252517_-\|acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|223894
NC_016024.1\|WP_148263875.1\|226947_227163_+\|hypothetical-protein	unknown	unknown	unknown
NC_016024.1\|WP_014098713.1\|249993_251442_-\|carotenoid-oxygenase-family-protein	unknown	unknown	gnl\|CDD\|226196
NC_016024.1\|WP_014098708.1\|243562_244489_+\|hypothetical-protein	unknown	unknown	unknown
NC_016024.1\|WP_148263876.1\|231480_231990_+\|hypothetical-protein	unknown	unknown	unknown
NC_016024.1\|WP_014098712.1\|248352_249954_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274108
NC_016024.1\|WP_014098714.1\|251452_252046_-\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|379122
NC_016024.1\|WP_014098707.1\|242708_243449_+\|lysophospholipid-acyltransferase-family-protein	unknown	unknown	gnl\|CDD\|153244
NC_016024.1\|WP_014098709.1\|244516_245437_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NC_016024.1\|WP_148263874.1\|225464_226094_+\|carboxypeptidase-regulatory-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|372685
NC_016024.1\|WP_187288391.1\|245454_246270_-\|dihydroorotate-dehydrogenase-electron-transfer-subunit	unknown	unknown	gnl\|CDD\|99814
NC_016024.1\|WP_014098704.1\|236876_240215_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380293
NC_016024.1\|WP_014098701.1\|230535_231450_+\|pantoate--beta-alanine-ligase	unknown	unknown	gnl\|CDD\|376824
NC_016024.1\|WP_014098706.1\|242285_242642_+\|aspartate-1-decarboxylase	unknown	unknown	gnl\|CDD\|376751
NC_016024.1\|WP_014098711.1\|246427_248356_+\|DNA-primase	unknown	unknown	gnl\|CDD\|235551
NC_016024.1\|WP_014098703.1\|233415_236877_+\|helicase	unknown	unknown	gnl\|CDD\|197275
NC_016024.1\|WP_014098699.1\|228425_229889_+\|DUF58-domain-containing-protein	unknown	unknown	gnl\|CDD\|224635
NC_016024.1\|WP_014098698.1\|227249_228404_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369376
NC_016024.1\|WP_014098700.1\|229910_230411_+\|LITAF-like-zinc-ribbon-domain-containing-protein	unknown	unknown	gnl\|CDD\|223021

Protein	Function_ID	Function_description	E-value
NC_016024.1\|WP_014098715.1\|252076_252517_-\|acyl-CoA-thioesterase	gnl\|CDD\|223894	COG0824, FcbC, Predicted thioesterase [General function prediction only].	3.89964e-37
NC_016024.1\|WP_014098704.1\|236876_240215_+\|hypothetical-protein	gnl\|CDD\|380293	NF033451, BREX_2_MTaseX, BREX-2 system adenine-specific DNA-methyltransferase PglX. This protein, PglX, is a site-specific DNA methyltransferase associated with PGL (phage growth limitation), a type 2 BREX (bacteriophage exclusion) system. The phage resistance appears not be restriction, but does manage to inhibit phage replication.	2.49311e-07
NC_016024.1\|WP_014098713.1\|249993_251442_-\|carotenoid-oxygenase-family-protein	gnl\|CDD\|226196	COG3670, COG3670, Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism].	4.59089e-175
NC_016024.1\|WP_014098700.1\|229910_230411_+\|LITAF-like-zinc-ribbon-domain-containing-protein	gnl\|CDD\|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	1.50506e-05
NC_016024.1\|WP_014098714.1\|251452_252046_-\|HD-domain-containing-protein	gnl\|CDD\|379122	pfam13328, HD_4, HD domain. HD domains are metal dependent phosphohydrolases.	4.21142e-30
NC_016024.1\|WP_014098707.1\|242708_243449_+\|lysophospholipid-acyltransferase-family-protein	gnl\|CDD\|153244	cd06551, LPLAT, Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis. Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).	8.86705e-41
NC_016024.1\|WP_014098709.1\|244516_245437_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	8.32993e-101
NC_016024.1\|WP_148263874.1\|225464_226094_+\|carboxypeptidase-regulatory-like-domain-containing-protein	gnl\|CDD\|372685	pfam13715, CarbopepD_reg_2, CarboxypepD_reg-like domain. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 90 amino acids in length. The family is found in association with pfam07715 and pfam00593.	3.6671e-06
NC_016024.1\|WP_187288391.1\|245454_246270_-\|dihydroorotate-dehydrogenase-electron-transfer-subunit	gnl\|CDD\|99814	cd06218, DHOD_e_trans, FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to orotate coupled with the reduction of NAD+. In L. lactis, DHOD B (encoded by pyrDa) is co-expressed with pyrK and both gene products are required for full activity, as well as 3 cofactors: FMN, FAD, and an [2Fe-2S] cluster.	9.17387e-88
NC_016024.1\|WP_014098701.1\|230535_231450_+\|pantoate--beta-alanine-ligase	gnl\|CDD\|376824	pfam02569, Pantoate_ligase, Pantoate-beta-alanine ligase. Pantoate-beta-alanine ligase, also know as pantothenate synthase, (EC:6.3.2.1) catalyzes the formation of pantothenate from pantoate and alanine.	4.67647e-148
NC_016024.1\|WP_014098706.1\|242285_242642_+\|aspartate-1-decarboxylase	gnl\|CDD\|376751	pfam02261, Asp_decarbox, Aspartate decarboxylase. Decarboxylation of aspartate is the major route of beta-alanine production in bacteria, and is catalyzed by the enzyme aspartate decarboxylase EC:4.1.1.11 which requires a pyruvoyl group for its activity. It is synthesized initially as a proenzyme which is then proteolytically cleaved to an alpha (C-terminal) and beta (N-terminal) subunit and a pyruvoyl group. This family contains both chains of aspartate decarboxylase.	1.77315e-77
NC_016024.1\|WP_014098711.1\|246427_248356_+\|DNA-primase	gnl\|CDD\|235551	PRK05667, dnaG, DNA primase; Validated.	0
NC_016024.1\|WP_014098712.1\|248352_249954_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274108	TIGR02393, RNA_polymerase_sigma_factor_RpoD, RNA polymerase sigma factor RpoD, C-terminal domain. This model represents the well-conserved C-terminal region of the major, essential sigma factor of most bacteria. Members of this clade show considerable variability in domain architecture and molecular weight, as well as in nomenclature: RpoD in E. coli and other Proteobacteria, SigA in Bacillus subtilis and many other Gram-positive bacteria, HrdB in Streptomyces, MysA in Mycobacterium smegmatis, etc. [Transcription, Transcription factors].	1.65464e-97
NC_016024.1\|WP_014098699.1\|228425_229889_+\|DUF58-domain-containing-protein	gnl\|CDD\|224635	COG1721, COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only].	3.51894e-25
NC_016024.1\|WP_014098698.1\|227249_228404_+\|hypothetical-protein	gnl\|CDD\|369376	pfam07464, ApoLp-III, Apolipophorin-III precursor (apoLp-III). This family consists of several insect apolipoprotein-III sequences. Exchangeable apolipoproteins constitute a functionally important family of proteins that play critical roles in lipid transport and lipoprotein metabolism. Apolipophorin III (apoLp-III) is a prototypical exchangeable apolipoprotein found in many insect species that functions in transport of diacylglycerol (DAG) from the fat body lipid storage depot to flight muscles in the adult life stage.	0.00241371
NC_016024.1\|WP_014098703.1\|233415_236877_+\|helicase	gnl\|CDD\|197275	cd09178, PLDc_N_Snf2_like, N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family. N-terminal putative catalytic domain of uncharacterized archaeal and prokaryotic HKD family nucleases fused to putative helicases from the Snf2-like family, which belong to the DNA/RNA helicase superfamily II (SF2). Although Snf2-like family enzymes do not possess helicase activity, they contain a helicase-like region, where seven helicase-related sequence motifs are found, similar to those in DEAD/DEAH box helicases, which represent the biggest family within the SF2 superfamily. In addition to the helicase-like region, members of this family also contain an N-terminal putative catalytic domain with one copy of the conserved HKD motif (H-x-K-x(4)-D, where x represents any amino acid residue), and have been classified as members of the phospholipase D (PLD, EC 3.1.4.4) superfamily.	1.09598e-26

>NC_016024.1|WP_014098704.1|236876_240215_+|hypothetical-protein
MNHLECIRQILESCGQQDVPALIASLFCEKLLWGHPPDGLKPCELQLNAPDSCEVTAAPVAQMSGLPVYLIDWPEDRLPGVTARRAVQRALAPTHAEHLLVYVARNRRQLAFTWARKRSDGKIELRTLPYEVGSPARTTVERLAELAFSLDELRAGEPPITRVTDKLTTAFSVEAVTKRFYQEVANWYFWALDHVSFPQDAPKTDGKDHVSLIRLITRLIFCWFLKEKGLIPATLFDPKSLPTMLNGFAPNEAASSVFYKAILQNLFFATLNTEMGKRDWAEDGQHFMAHNLYRHRELFQNPETALELFRDIPFLNGGLFECLDRIEGTKEQPRYIRIDGFSRRPDSQPVVPDVLFFGDEREVDLRHAYGETRDRCARVRGLIHILASYNFTLQEHTPFDQEVALDPELLGQVFENLLAAYNPETRTTARKATGSYYTPREIVDYMVDEALIASLKTRLEATFPDTKNVEDRLRHLFAYNDEPHQFTDAEVEALIHKPHQFTDDEVKALIHAIDHLKILDPACGSGAFPMGILHRLVFVLGKLDPNNARWKERQIAKALEIPDATVRDKVIADIKASFTSNELDYGRKLYLIENCIYGVDIQPIAVQIAKLRFFISLVVDQRVDPEAENRGIRALPNLETRFVAANTLVGIARPRQPALRHEEVNTLERKLAQVRAAHFTAKTPATKRKYRECDATLRAEIAEILKTDGWDDETARLLAAWDPYDQNASASFFDSEWMFGLKEGFDIVIGNPPYSAEISSLDREKIACKDTKNSNSAAIFIDVAKNNLTHQWGLVSFVVPKSLLYSERWFSLVEALAPNTKILVDLEQAFESVLLEQVVFVFQHSQSVPLYRAYKFHGSKFIQRASVPVSCVSQFHTWPCDVSDEELRLGMKMSKSGLFLRDVSRSFRGLPLQQKISDYGEEHRDVCVIGGKNIVRYGTNGFKGYLRKDDLDGASNKVKMLLQPKVVSQQIIAHIQNPKPHIMIIASVDPDGSILGLDTVENTIPINAPIHLNMIAALFNSSLINWYAYRFIYCAAVRTMHFDEHYIGKIPLPLDYRYKQDDIVALVDKILDAKRANPNADTSALEREIDEHVYRLYGLTPDEIRIVEESLK
>NC_016024.1|WP_014098703.1|233415_236877_+|helicase
MPKIYDNIEWPLVEGLRRILPEAVACSFCVGYLNLRGWDQLADSIEHLGGSDEHHACRILVGMHRPPDEGMRLLQGIHRQTGATGQPSLPIDGPTAARLRRRITESFKEQLEFGVPSNAAERTLQQLSRQLRERKVFIRAFLRYPLHAKLYLVRREDTVTPLIGFVGSSNLTLAGLSRQGELNVDVVEQDAARKLQGWFDERWNDDLAVDLSSELADLIDQSWARKELIRPYLIYLRIAYHLSEDARQGEREFKVPAMFRDVLLDFQKAAVSLAAKKLHRHGGVLLGDVVGLGKTLMATAIARLMQEDSGDNTLVICPPKLAPMWDRYMQEYQIAGRVLSIGRAISELPGLPRYRLVIIDESHNLRNREGERYKAIQEYIAQNESRVLLLTATPYNKHYTDISNQLRLFLDEDRDLHVRPERYFQWLARKRGETEADFIARFQTSPHSLRAFEQSLFPEDWQDLMRLFLVRRTRQFIIRHYAEFDAASGRHYVRLNGQPHYFPARQPKRVNFAINEADPKDQYARLFRDEVVKVIEDLALPRYGLANYLKPKAEKGASAEEKRILANLNRAGKRLIGFCRINLFKRLESSGQSFLLSVQRHMVRNLITLHALEKNLPIPIGTQDAAMLDTAMSDADEAAVDISDPDNIEAAEATEPPAQKEKTWDEYQKRAGEIYKAYRQNHHDRFDWLNPRFFTKKLADALRSDTQALHRILESAGQWQPAADTKLQALLELLRTHRDEKVLVFTQFADTALYLHKQLRATGMEDVAVLTNQVGDPVTLSRRFSPSTNGGLAAGETGLRVLIATDVLAEGQNLQDAHIVVNYDLPWAIVRLIQRAGRIDRIGQKHDTILIYSFWPAEGVEKIIRLRQRLVARLQQHQEVIGSDDSFFGEAAAQRLRDLYTEKAGTLDDEGADEDIDLASLALQVWNSASADDRKACLSLPPIVSATRALRCSGERPFAPADGPPGVVTYLRYPDGTDALIRVDEHGSLVSQSLSAIFRDIACPPETPPLERTEQHHELVARCVEMATEEHVTGGHLGSLRSVRRKLWERLNKYRDRLKAGEGELPFAPAVSPDRLQQLDAVLDMIWWYPLKSAAREAISRQMRLGIADPDLLDMVARRAGEDNLCEIREKEADESAGPHIICSLGLIATGAK
>NC_016024.1|WP_148263877.1|232511_232772_+|hypothetical-protein
MPRQRQLNLAVGFNPRIRGGNPRITSPPIVSRRVATDECHRQGASDTSRNPCGRDARAPRRVALATIEFSPAFQRRENGVTSPRVV
>NC_016024.1|WP_148263876.1|231480_231990_+|hypothetical-protein
MSTSRLRWMGVVWVLALAVGVGAQDAGLQDAGRTGEGRQGTIVNSRTGYAQLLGRHKLQLQWISWFEPKKSGDLTVTDRQGLLVIQGAQRDPRTGDFVEVDGIVTRVEDRTFDFRGRIVTRVSHINGGEPCLREGDMTFAIKGKRRFWRLQQMDNPCDGVTDYVDIFLR
>NC_016024.1|WP_014098701.1|230535_231450_+|pantoate--beta-alanine-ligase
MKIIREPHEMQQTALTLRDKAIRIGLVPTMGAFHDGHVSLMRRAKQENDVCVVSLFVNPLQFNDPSDFERYPRDEAADLEIARTVGVDILFMPSAAAMYPPDAQTFVEVTRVSQPLCGRHRPGHFRGVATVVAKLLMITLPRRVYFGLKDYQQCRVVAQMARDLYFPPDLVFCPTVREADGLAMSSRNARLSPEERRAAVVLPRSLELAQELFAAGETNPAVIRERVHGQLMTEPLAEVEYVEVVDAQTLEPITEITQPALVAIAAHFGRTRLIDSVVLTPPRPEPEPSAPDPLDISDVPGRAR
>NC_016024.1|WP_014098700.1|229910_230411_+|LITAF-like-zinc-ribbon-domain-containing-protein
MIVCVNCGQVNETAASRCLRCGASIFEYPSYLGSAGVAPSGPPPAPPPPSVPPPKPAPPPHKQPLPPPYGSPYGASQTAAPPPMPLPPPVSPPLAHPLPVQPVVVVGGFACPYCRTTLPPRITYRTSPAGWVIFALLLLLCWPLFWVGFLFQEECLRCRNCGRRLA
>NC_016024.1|WP_014098699.1|228425_229889_+|DUF58-domain-containing-protein
MLATFRERLASPEFRAELKSATIAFVITSLLFGSSLLCLVLGFLIQLLPAYNVDLLAEVLFALSLGLAAIAGVYVIPRLARRVRMELARLDISYAPTQETAFFVLLTVVVALSAFNTGNNLLYLIFAILISVIVASGIVSESMLRGLTVGLRFPEHIHAGQAAVLEVSVANQKHLVPSMSLTVGVRVSQKAGPRLPARDTVKRWWTWRGKSPNKPQNSSPADTTKMDNLVHFVIVGPRARVRQTIEHRFPARGQYNITGFTVTTKFPFGFLQKTRRFAASGTIVVYPAVDAAVSVPKALSEALGARETNRRGLGADLYAIRQYRDGDRRRDIDWKATAKTRRLMVRDRLREDERRVTVRFDPRPARDLSDAELAAFETGVTYAASLLNRLVKSGVLVRLVTPEAATEFGNTPRHLHDMLRILAVVEPRREVSATGSAPNLPTREPAPEVVFAWNGLPAGGPVLARISFDDLPLADDLKPEDKAKKDV
>NC_016024.1|WP_014098698.1|227249_228404_+|hypothetical-protein
MTDYFDRFSEWRRKIQRKAEEVDAQLGLSEAIGKTVEKTVEQTEKLTEEVRRATGQLSASFQRAAENAPEVVSEVVQEVVHAVEEVSERLPDAQTVTDTMARVVETVRDEFRNLDEKHHVTENLKQAAEKVADKVTEVGAETLRTGGEKASEVVDRAGEAFDAVRETAHRYYSRAEEAYNFGSRVFHATVETRDGYRKAREWVVANPGTSALMGLSLLLGFRLGAAFPGLDRVVVGQSRHWLFHSGLAAYGAKQLAERYMRFLREQERLVAEGRLDEAAQARVAFQRKAARYVGAPLLGAFNVALGTALWAEIFSPGRIVGFPISIVLGGNPVLETVWLFGNGLVCIYTGYELVMLAFEDEADVQRVVRAIRALLPEADSSQAA
>NC_016024.1|WP_148263875.1|226947_227163_+|hypothetical-protein
MSWRRGHPARMMSWERGHPARMNPTGGFNRRYATGGGLGAYVIRGLKPTAKFNRRYATSLGGRASCPQDEM
>NC_016024.1|WP_148263874.1|225464_226094_+|carboxypeptidase-regulatory-like-domain-containing-protein
MKPLRVFALMGLGWLVLGSGAGEAPAQFSVAAGSLTVRGRVLDAQTKQPLVNAQVNIRTKYDDYRTLTDAEGYYTLQVSAGRELRDFELIFSHPDYREKYFHTAFQPVLRDDLTATVEPLRARVKYRKNKLDMPCGDRKALITKSGDTLSCTFACESAPALTVRLPAGNEMRVTAAGGFSLRITDEKVELRGAENQAVALQVTAVMFRR
>NC_016024.1|WP_014098706.1|242285_242642_+|aspartate-1-decarboxylase
MFRLMHKSKIHRATVTEANLNYTGSLTVDQDLLDAADILPNEKVSVVNINTGARFETYAISGPRGSGTICLNGAAARLGTPGDLVIIISYGLFTDEEARHLKPRVVKVDAHNRLLPEA
>NC_016024.1|WP_014098707.1|242708_243449_+|lysophospholipid-acyltransferase-family-protein
MLPAQPSPLFQRVVHAYNQHLLRRAFHAVWWRGVDVFTAEPRRPLLIYANHPGWWDPLLAFFVVRRTGRDGYMMGEETTLRTFRFFRWMGGFSVNRADARDVARSIRYASERLAAPSTALWIFPQGEIVPPDKRPLTFLPGTAHILRRTTACIAVPTAIRYEFHDQPRPEVFLDFGPGELIRGAEVHDITALTCHLQARLTERMDALRDAVWERRPEGFSLALRGQPSISDRYAAVVARLTGKRTG
>NC_016024.1|WP_014098708.1|243562_244489_+|hypothetical-protein
MSEGVFSVRRPVWWAAAVGGVFVSAALFSPTVRAVGQSFLDAFRLPRVVAIGLDDQQMTALRERLNRVQSKFDLPALVAENVEVAEPTVRSARVNSAREAGQVAGMAVRTPAWLPEGVTMQDMRATSSGGGARFKVDVGFANQVLDFLELRDALLPASLDGQTIAFRLGGRVETSFARGDEHRFALVQARLPEVSLPEGTSLTPFGYAYLRMLGMDAEAAHRVAATTDWRSTFVLPIPARFHDLQQVIVRGQPGFLLTPHAVEEAPRRNRRWQPVRATTLAWTEGDQVFVLSGNLTEQEALTIAGALQ
>NC_016024.1|WP_014098709.1|244516_245437_+|ABC-transporter-ATP-binding-protein
MTAGNWVIEAEGLRKVFGRKVAVADLSLRVAAGEVFGFLGPNGAGKTTAMKMLLGLVHPTAGRGFVLGHPVGSREARRWVGFLPEHFRFHDWMTGRELLNFHGQLHGLPATARAKRIETLLAQVDLADAGDRPVGTYSKGMQQRLGLAQALIHQPKLVFLDEPTSGLDPIGRILVRDLIVRLRSEGVTVFFNSHILGDVEAVCDRVVFLKRGRVVHETALREGLTPELHLRLGEVPPELVRGLAAFGRVLRTAEREVWLQLEQETAVPGIVRWLVERGAAVYGVWVQRPSLESLFLETMGPEERAG
>NC_016024.1|WP_187288391.1|245454_246270_-|dihydroorotate-dehydrogenase-electron-transfer-subunit
MQDIRLTVTGHRTFGSYGHLTLTAAEPLTFAPGQFAMLKPAGALDPMWRRAMAIYRLRRSGAGSQVEFIYQVFGRGTQALRRVHAGDAVQALLPLGRPFDIAPVAVGGREALLVAGGVGSAALLALAEQLKREQVATRLFLGGRSTVDLIGLEDFTALGIPVHVATNDGSRGVRGFVTTPFERFLHDHADEVRSGKFVVYACGPGPMLERVAALTAAACILTYVSVEERMACGFGVCVGCVVAVRGQDGATDYRRACVEGPVFRADELEWT
>NC_016024.1|WP_014098711.1|246427_248356_+|DNA-primase
MLLDRQTVDDLRAQADIVRVVSGYVTLRKRGANYLACCPFHSEKTPSFNVHPGKQVFKCFGCGIGGDVFTFVMRMENVGFAEAVRIVAEVCGLPLPEARPAAPPAHGKGAHQEGGLPEAEERERLLRLHELALRFFQSQLAAPEHYAAREYLARREVAPSTIAALGLGYAPDRWDALLTFLRSHGASLTDLERGGLVTPRESGSGGYDRFRGRIMFPIADSQGRVVAFGGRTLGDGEPKYLNSPETPLYVKGKHLFGLHLAKEAIRRSGFAILVEGYMDFLRLYQEGVHNVVATLGTALTEAQVRQLRRYLETPKVVINFDSDRAGQAATRRGFELLLEQGFRVNVLHLPEGKDPDDFVRAQGVRAYRACLRQSQPLVEYLADAAGLEYDLTRPAGRAQAVNAVLPYIAKLNDPIERALAAERLADRLQLDVGLIRTALEQSARERRTELAVETVEVAAKLTLAERQVLQVLLSHPPLCELAFAALDDELISMLPGRVFFRAVREVYLKGEPFAYAPLAAAVARWQRAETSGNAHGQFDFLAEADHTPTPLDREMENYVAELLLGAEPPADDTALAKYRSILEDGLLVLQQRRLEHQSAAMHRNVQKAAESDDEQLALRYAHERLQLKRARLAALHHRQKKP
>NC_016024.1|WP_014098712.1|248352_249954_+|sigma-70-family-RNA-polymerase-sigma-factor
MTGETTQPLVTQVITAARGRAFLSYDELNALLPLGMTDVAVIEALLSALERRGIRVGEEHERPLPAGAIPVGAVHGTAPTTAPASPTAFFEDPLRPYLQEMGRIATLSAEEEAALVAGIRRAEVRFRKQLSRVPATAVLLVEKAEAMARGDGAAARWFDLSGTAAGPEPGETASSEAASLEAALDEAVARMRQALEAVQDEWSLLSAVADLPASADWQRRRLARARILLSRAVLDVPLSRTGYTSLLEALEAGRRTNAAWLLTAAEPAEVARTLAQARQMFDRAAAARQRLVETNLRLVVSVARHYTHRGLGLTDLIQEGNLGLLRAAERFSGQRPERFASYATWWIRRAIAQALSEQPRLIRLPAAVRAELTRLLEAMHRLTLERRREPKQAELAEHLGMSLEKVQMLLQLAQPPVSLETPVGDEEDQSLGDFIADTHAPNPLDDAARVRLREDLNAALQSLNAREEKVLRMRFGLGADGKAYTLEEIAQFFALPRERIQRIEAEALRKLRRPARSQRLRQFLDDTAHDASA
>NC_016024.1|WP_014098713.1|249993_251442_-|carotenoid-oxygenase-family-protein
MAAPAPQPTTRRWNRADWLRGYTSLTEERDYWIDDIEGNLPADLCGTLYRNGPGLLERGGQSVQHPFDGDGMICAFDFTGDGRVRFRNRYVRTAGFIAESKAGRFLQRGVFGTQKPGGWLANAFDLQAKNIANTNVAYSPKKLLALWEGGKPYALDPQTLETIGEDDLGGALAGNANFAAHPHYDRRTGEMVNFGIEPGLSSTINLYTLDANLNVTAQHRWEVPGFAFIHDFALTDDYAVFFQNPVTVNPLPYWFGFRGAAECLVFQPDRPTKVHLLPRHGGRMRTYETVACFVFHHVNAHIADDVLTVDSIAYETFPSLEPGTMYRQVEIEKIAASQLFRFTINLKTGASRRERLLERAVEFPSVHPARVGLPHRWAFMAMADAPTGNAPLQGVLAYNTHTGETQTYSFAPGGYVGEPVFVPTPGATEENAGYLLQMVFDARRGTSGLAIFDARNVAGGPLARLHLRDTVPYGLHGQFVAK
>NC_016024.1|WP_014098714.1|251452_252046_-|HD-domain-containing-protein
MLSERYDAALVFAHQLHRHQKRKGTEIPYISHLLSVSALVLEHGGTEDQAIAALLHDAVEDQGGDAIRQEIRHRFGEDVAAIVDHCTDTDQIPKPPWRARKEAYLAHLRTTPDTARLVSLADKVHNARTILADYRTVGEALWSRFEGGREGTLWYYRRLVEIFAAGPCQPLANELERTVAELERLASLASPQAEPHA
>NC_016024.1|WP_014098715.1|252076_252517_-|acyl-CoA-thioesterase
MATDSALPSSVISRLRVRYAETDQMGVVYHANYLVWMEIGRTDYCRACGYAYRAMEAAGLRLVVAEARVRYLSPARYDDDIHLTTRLLALRSRQVVFGYDIRRATDDTLLATGETTHLPTNHAGRIIRLPADIHAALSTGPTGQAA

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Crispr_ID: NC_016024_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016024_3

598037-598149

Orphan

Consensus_repeat	Method
TCACGCTGAAGTCTGAACAGCAGGCGCTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_016024_3

>merge|NC_016024|3|598037-598149|CRISPRCasFinder
TCACGCTGAAGTCTGAACAGCAGGCGCTGCTGACGGAAGTTGCGGCTGTAAAGGCCGCGCAGCAGACGTTGATGACGGAAGTCCTCACCCTGAAGTCTGAACAGCAGGCGCTG

>NC_016024|3|2|598037-598149|CRISPRCasFinder
TCACGCTGAAGTCTGAACAGCAGGCGCTG	CTGACGGAAGTTGCGGCTGTAAAGGCCGCGCAGCAGACGTTGATGACGGAAGTCC
TCACCCTGAAGTCTGAACAGCAGGCGCTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_016024.1\|WP_014099006.1\|594440_595286_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|224271
NC_016024.1\|WP_014099005.1\|593912_594437_+\|cyclic-pyranopterin-monophosphate-synthase-MoaC	unknown	unknown	gnl\|CDD\|376690
NC_016024.1\|WP_014099015.1\|605108_605651_+\|hypothetical-protein	unknown	unknown	unknown
NC_016024.1\|WP_081464651.1\|589762_590464_+\|YARHG-domain-containing-protein	unknown	unknown	gnl\|CDD\|372555
NC_016024.1\|WP_014099009.1\|598559_599513_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|284659
NC_016024.1\|WP_014099003.1\|590651_592064_+\|SpoVR-family-protein	unknown	unknown	gnl\|CDD\|377285
NC_016024.1\|WP_014099007.1\|595357_597547_+\|peptidylprolyl-isomerase	unknown	unknown	gnl\|CDD\|238194
NC_016024.1\|WP_014099018.1\|607786_610285_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225523
NC_016024.1\|WP_014099000.1\|586659_588330_-\|M20/M25/M40-family-metallo-hydrolase	unknown	unknown	gnl\|CDD\|349910
NC_016024.1\|WP_014098998.1\|583139_584327_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|370813
NC_016024.1\|WP_014099016.1\|605660_606686_+\|threonylcarbamoyl-AMP-synthase	unknown	unknown	gnl\|CDD\|223088
NC_016024.1\|WP_014099011.1\|600190_600967_+\|bifunctional-demethylmenaquinone-methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol-methylase-UbiE	unknown	unknown	gnl\|CDD\|234689
NC_016024.1\|WP_014099012.1\|601003_602587_-\|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	unknown	unknown	gnl\|CDD\|234854
NC_016024.1\|WP_014099010.1\|599509_600079_-\|ubiquitin--protein-ligase	unknown	unknown	gnl\|CDD\|238117
NC_016024.1\|WP_014099014.1\|603975_605076_+\|phenylalanine--tRNA-ligase-subunit-alpha	unknown	unknown	gnl\|CDD\|234780
NC_016024.1\|WP_014099017.1\|606792_607746_+\|bifunctional-riboflavin-kinase/FAD-synthetase	unknown	unknown	gnl\|CDD\|235536
NC_016024.1\|WP_014099001.1\|588526_589747_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_016024.1\|WP_014099004.1\|592171_593500_+\|phosphomethylpyrimidine-synthase-ThiC	unknown	unknown	gnl\|CDD\|376689
NC_016024.1\|WP_014099013.1\|602735_603968_+\|prepilin-peptidase	unknown	unknown	gnl\|CDD\|377700
NC_016024.1\|WP_014098999.1\|584323_586627_-\|oligopeptide-transporter,-OPT-family	unknown	unknown	gnl\|CDD\|224216

Protein	Function_ID	Function_description	E-value
NC_016024.1\|WP_014099006.1\|594440_595286_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|224271	COG1352, CheR, Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms].	1.26646e-51
NC_016024.1\|WP_014099005.1\|593912_594437_+\|cyclic-pyranopterin-monophosphate-synthase-MoaC	gnl\|CDD\|376690	pfam01967, MoaC, MoaC family. Members of this family are involved in molybdenum cofactor biosynthesis. However their molecular function is not known.	1.32535e-74
NC_016024.1\|WP_014099016.1\|605660_606686_+\|threonylcarbamoyl-AMP-synthase	gnl\|CDD\|223088	COG0009, SUA5, Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis].	9.33736e-79
NC_016024.1\|WP_081464651.1\|589762_590464_+\|YARHG-domain-containing-protein	gnl\|CDD\|372555	pfam13308, YARHG, YARHG domain. This presumed extracellular domain is about 70 amino acids in length. It is named YARHG after a conserved motif in the sequence. This domain is associated with peptidases and bacterial kinase proteins. Its molecular function is unknown.	1.97403e-26
NC_016024.1\|WP_014099009.1\|598559_599513_-\|hypothetical-protein	gnl\|CDD\|284659	pfam07291, MauE, Methylamine utilisation protein MauE. This family consists of several bacterial methylamine utilisation MauE proteins. Synthesis of enzymes involved in methylamine oxidation via methylamine dehydrogenase (MADH) is encoded by genes present in the mau cluster. MauE and MauD are specifically involved in the processing, transport, and/or maturation of the beta-subunit and that the absence of each of these proteins leads to production of a non-functional beta-subunit which becomes rapidly degraded.	0.001887
NC_016024.1\|WP_014099003.1\|590651_592064_+\|SpoVR-family-protein	gnl\|CDD\|377285	pfam04293, SpoVR, SpoVR like protein. Bacillus subtilis stage V sporulation protein R is involved in spore cortex formation. Little is known about cortex biosynthesis, except that it depends on several sigma E controlled genes, including spoVR.	0
NC_016024.1\|WP_014099007.1\|595357_597547_+\|peptidylprolyl-isomerase	gnl\|CDD\|238194	cd00317, cyclophilin, cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug cyclosporin (CsA). Immunosuppression in vertebrates is believed to be the result of the cyclophilin A-cyclosporin protein drug complex binding to and inhibiting the protein-phosphatase calcineurin. PPIase is an enzyme which accelerates protein folding by catalyzing the cis-trans isomerization of the peptide bonds preceding proline residues. Cyclophilins are a diverse family in terms of function and have been implicated in protein folding processes which depend on catalytic /chaperone-like activities. This group contains human cyclophilin 40, a co-chaperone of the hsp90 chaperone system; human cyclophilin A, a chaperone in the HIV-1 infectious process and; human cyclophilin H, a component of the U4/U6 snRNP, whose isomerization or chaperoning activities may play a role in RNA splicing. .	2.35162e-60
NC_016024.1\|WP_014099018.1\|607786_610285_-\|hypothetical-protein	gnl\|CDD\|225523	COG2976, COG2976, Uncharacterized protein conserved in bacteria [Function unknown].	3.57721e-08
NC_016024.1\|WP_014099000.1\|586659_588330_-\|M20/M25/M40-family-metallo-hydrolase	gnl\|CDD\|349910	cd05660, M28_like_PA, M28 Zn-peptidase containing a protease-associated (PA) domain insert. Peptidase family M28 (also called aminopeptidase Y family), uncharacterized subfamily. The M28 family contains aminopeptidases as well as carboxypeptidases. They have co-catalytic zinc ions; each zinc ion is tetrahedrally co-ordinated, with three amino acid ligands plus activated water; one aspartate residue binds both metal ions. This subfamily is composed of uncharacterized proteins containing a protease-associated (PA) domain insert which may participate in substrate binding and/or promote conformational changes, influencing the stability and accessibility of the site to substrate.	9.89985e-84
NC_016024.1\|WP_014098998.1\|583139_584327_-\|hypothetical-protein	gnl\|CDD\|370813	pfam10092, DUF2330, Uncharacterized protein conserved in bacteria (DUF2330). Members of this family of hypothetical bacterial proteins have no known function.	0.000287319
NC_016024.1\|WP_014099011.1\|600190_600967_+\|bifunctional-demethylmenaquinone-methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol-methylase-UbiE	gnl\|CDD\|234689	PRK00216, ubiE, bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE.	1.66107e-113
NC_016024.1\|WP_014099012.1\|601003_602587_-\|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	gnl\|CDD\|234854	PRK00881, purH, bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional.	0
NC_016024.1\|WP_014099010.1\|599509_600079_-\|ubiquitin--protein-ligase	gnl\|CDD\|238117	cd00195, UBCc, Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin protein ligase enzymes, E3. This pathway regulates many fundamental cellular processes. There are also other E2s which form thiol-ester linkages without the use of E3s as well as several UBC homologs (TSG101, Mms2, Croc-1 and similar proteins) which lack the active site cysteine essential for ubiquitination and appear to function in DNA repair pathways which were omitted from the scope of this CD.	1.16844e-05
NC_016024.1\|WP_014099014.1\|603975_605076_+\|phenylalanine--tRNA-ligase-subunit-alpha	gnl\|CDD\|234780	PRK00488, pheS, phenylalanyl-tRNA synthetase subunit alpha; Validated.	0
NC_016024.1\|WP_014099017.1\|606792_607746_+\|bifunctional-riboflavin-kinase/FAD-synthetase	gnl\|CDD\|235536	PRK05627, PRK05627, bifunctional riboflavin kinase/FAD synthetase.	8.21024e-125
NC_016024.1\|WP_014099001.1\|588526_589747_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.57228e-71
NC_016024.1\|WP_014099004.1\|592171_593500_+\|phosphomethylpyrimidine-synthase-ThiC	gnl\|CDD\|376689	pfam01964, ThiC_Rad_SAM, Radical SAM ThiC family. ThiC is found within the thiamine biosynthesis operon. ThiC is involved in pyrimidine biosynthesis. ThiC participates in the formation of 4-Amino-5-hydroxymethyl-2-methylpyrimidine from AIR, an intermediate in the de novo pyrimidine biosynthesis. Thic is a member of the radical SAM superfamily.	0
NC_016024.1\|WP_014099013.1\|602735_603968_+\|prepilin-peptidase	gnl\|CDD\|377700	pfam06750, DiS_P_DiS, Bacterial Peptidase A24 N-terminal domain. This family is found at the N-terminus of the pre-pilin peptidases (pfam01478). It's function has not been specifically determined; however some of the family have been characterized as bifunctional, and this domain may contain the N-methylation activity (EC:2.1.1.-). It consists of an intracellular region between a pair of transmembrane. This region contains an invariant proline and two almost fully conserved disulphide bridges - hence the name DiS-P-DiS. The cysteines have been shown to be essential to the overall function of the enzyme in, but their role was incorrectly ascribed.	2.46975e-44
NC_016024.1\|WP_014098999.1\|584323_586627_-\|oligopeptide-transporter,-OPT-family	gnl\|CDD\|224216	COG1297, COG1297, Predicted membrane protein [Function unknown].	6.08809e-94

>NC_016024.1|WP_014099007.1|595357_597547_+|peptidylprolyl-isomerase
MMNRRHFLSLCCLTAGWCSTVWGQRRPGPPPVLGRANSAQRVFARLLQLEDERYYHAEEFVDFLGSSNARVRRRACLALGRIGDPRSYTLLLERLYDDGNPRVRAMAAFALGELETTEPLEDLRRMLVRETEMLPVRARCAEALGKIAAANAKTLDADTLQGLLAAGLKSLPRPTEDIPPGSERELFTTLCLTAVMRMRQAAGLPPLLRWLASPNANVRFHAANALARLSDLPEAEKTLTREREKLVAAFRDEGETVVQVALARVLGAIGDAEAMAALLPRLAAAEAAVRIAVIRALSNARQPEEVVPPLLDRLRAGLSRYAKVEADERPTWDGLPELLTLAEALGRLKATEAQPWLERLRMLPTGRLGANPEVEIALARLGTAAFLGANPDKPLLPPDDDWRAQAHYFAGLAALPPEEPRRRRVVEDFLARTVLDARARTALLAAVPKTPAWAAVWEQELRHPDVMVRAAAAAALEVLPPTDQGRKALIAALTTAREDTQNDARLAILKALAADPHPDTEAAFDLALRDPDWLVRRQSGEILRRRLPSTLSEEERAQAGEMLDSRIGICRTNRPAAFYGRLVRQYARHPRAVITTTKGELTLELFSEDAPLTVENFIALAERGFFDDLTFHRVVPNFVVQGGDPRGDGDGGPGYQIRCEINERPYLRGSVGMALSGKDTGGSQWFICHLPQPHLDGGYTCFGQVVEGLETLDRLVRQDRILGIRLVKD
>NC_016024.1|WP_014099006.1|594440_595286_+|methyltransferase-domain-containing-protein
MPVKKRNLTNPHLPQLEKALAQVYGWAPNETLRAALQAVVTDKARRLLFDEMTYCRVAAQSPGELHSVAEEIALGETSFFREPEQFRALWRMVLPELIEKRADTKRLRLWSAGCSTGEEPFSLAMILEDLLGEASDWRIEILAVDLRSKALLHASQGRYHPLQLRNLDPALRDRFFHGSQSPDAPPGELDRRLRRNIRLRHANLYDPHLWQHLPGPFDVIVCSNVLTHMHYTAVQQTTARIQQALAPGGYLLVGSVEVGLVNQARLRPSQALPRGFFHRPE
>NC_016024.1|WP_014099005.1|593912_594437_+|cyclic-pyranopterin-monophosphate-synthase-MoaC
MPFSHIDETGRLTMVDVGEKPITDRTATASGVVLMRPETVAAIRARTTPKGDPLEAARLAGILAAKQTDRLIPLCHTLPLAYVNVELTLAADHILITATARARASTGVEMEALTAVSVAALTLFDMCKAIDRTMRITDIQVRSKTGGASDWPASETPTSDVPPSPGLTSSGAET
>NC_016024.1|WP_014099004.1|592171_593500_+|phosphomethylpyrimidine-synthase-ThiC
MLACAGKITEEMIAVAEDERLDPEFIRQGLADGTIVIPKNIRHHFRPIGIGKGLRTKVNANIGASGYHQLLEEEIAKLHAAVQYGADSVMDLSTGTDLDLIRETLIRESPLMLGTVPIYQVAAEGSILKMDPEELFAVIEKQAQQGVDYMTVHCGVTKETVRKLRQHQRIEGIVSRGGALLAAYIEATGNENPLYEQFDRLCDIFARYDVTFSLGDGLRPGATSDASDRGQLAELLVLGELVARAREKGCQVMVEGPGHVPLDQIVANVQLQKRVCDGAPFYVLGPLTCDVAPGYDHITGAIGGAIAAAAGTDMLCYVTPAEHLRLPDRQDVIEGVIATRIAAHSGDLVKGVKGAKAWNDQMSRYRKQLDWDGMFRLAMDPEKARRYKEESEAANAKVCSMCGSLCSINIDNAAIGKFSGQKPDTSEKFLTPRPAAAVAGRD
>NC_016024.1|WP_014099003.1|590651_592064_+|SpoVR-family-protein
MDKEFAALEEALERIWEIARGFGLDPFPVNFEIVPATVMYEIGSYALPGRFSHWTFGKAYHRMKTMYDFGLSRIYEVVINTNPAYGFLLETNSPLQNKLVMAHVLGHVDFFKHNAYFAHTNRRMVDEVNLHAARIEEYEFKYGRKTVEAFLDAVLSIEEHIDPNFFIRKERDLPPPPEKKSTSGRENPFEDILRLGEKPAGETAPPPKRKPGELVYPEKDLVWFIANYSPVLEEWQRDVMMMIHDEMLYFVPQMQTKIMNEGWASYWHARIMRELCEGTDEFVEFAELHASVVSPHKGQLNPYYLGYKIFEDIERRWDNPTAEEREAYGRPGGQGREKIFEVREVESDVSFLRNYLTEELVEELDLYVYELVDDEEWTITEKRWERVRDQLVANMTNFGFPYIEVTDGDYNRNRELYLTHRFEGVELDLKYARKVLEYIYTLWGRPVHLETRADNEPLVLHYDGSSHDED
>NC_016024.1|WP_081464651.1|589762_590464_+|YARHG-domain-containing-protein
MPPVVEPAPSPALPTRSDTPALDTPAEPAAEPPAPPTSLEPGSEGFYVIAFSAKTAEAAEARKQSYLKAGLQPFVVKTDDWTNFEPGFYIVALGIYPTEAEAKAVASLAKEKGISAYTKASGPPRQPEAAGPDAPNPDDVPGDFPEASLRDLTDDDLRDLTAEELRLMRNEILARHGYRFSDPELAAHFGAQPWYHPTDGNAEDKLTAVERRNIERIRQAEKQARAAERTPRD
>NC_016024.1|WP_014099001.1|588526_589747_+|serine/threonine-protein-kinase
MQPGDTLGPYTLVRLLGRGAFGQVWLAERRTALAVTRVALKIPLADDVDLDAIRKEASIWAQASGHPNVLPIIEADIYDGQVVIVSEYAPDGSLVDWLVRKGGVVSLPEAAKMVDGILAGLEHLHARQIVHRDLKPANVLLQGETPRLADFGIARVVRATSHTGHIAGTPAYMPPEAFDGVRTEQGDLWAAGVVFQQLITGRLPFPQADLPSLMAAILTREPAPLPADFPPAVRSFLATALCKDPAHRFATATAMRRALAQAVAASAPVGAWGASPATAPARPATDSRAAAVTVPAASVPAPVSTPAGAAPSAIPATPTADTLPLPPDRAAGLGPAASAALGSHNKNRLDSETPGTESRGNQGRESQGRESQGWWWIAAGVAVTLLLGATLFLALLVYFQGQAFRS
>NC_016024.1|WP_014099000.1|586659_588330_-|M20/M25/M40-family-metallo-hydrolase
MKTLRLGVAGWWLLWLVIQIGMPVRATETVSVPAEVRAILARIQPATLRAHTELLSDDLFEGRAPGTRGGLLTAKYIAAQFQTYGLEPLGGSYFQNVPIVNLRAIPTTMTFRAASGATVELAYGTEFTAQSGECLPEVRFDDVPVVFAGYGIVAPEYDWNDYKDVDVRGKIVMLLVNDPGLHNPSIFQGRTLTYYGRWTYKYEEAARQGARGVLLIHTTESATYPWQVVQSSNTGTRSELVRDANSPPVVALKSWITDDAAVRIAQLGGKRLATLIEQAERRDFRPVPLDTTLSLHLKSEVSTLESPNVVGWLPGRDEKLRDECVVVTAHYDHFGVKEDPASGQRLIYRGALDNASGVAALLAMAEALGKSDWRPRRSVLFLSVTAEEQGLLGAQYYCEHPLIPLEKTAANINLDEVNVFGRTRDFVPLGAERSTLGKTIDALAKLEGLVMKPDPFPQNGSFFRSDHFCFAKAGVPCLSLNFGVEVEGKPEGWGKQRFDTYVRRDYHQPTDTIQEDWDFRGAAQHAQFALLIVATVADDPAMPDWLPGEAFQRKKT
>NC_016024.1|WP_014098999.1|584323_586627_-|oligopeptide-transporter,-OPT-family
MSTQVESPAATHFQPFVASEAVLPEFTLRSVLVGVILGIVFGASSVYLALKVGLTVSASIPIAVLSITIFRALGKSSILENNMTQTIGSAGESVAAGVVFTVPALLLMGYALDLSRTTLTALTGGWLGVLLMIPLRRALIVKEHGKLTYPEGTACAEVLIVGEKGGSQARLVFGGFGLALLYKFLMSGLHLWKEYPEKALGKALPGATLSAEVSPELMGVGYIIGPRVAGIMLAGGALSYLVLIPTIVFFGSGLSEPLFPAAKLIRDMSPSDVRTNFVLYIGAGAVATGGIISLVRSLPMILSAFRAGVGGFKAAAATAVVRTENDLPMNFVLGGAGLLWIILSTVIYFTAGELGFSLLAAAMIIAFGFFFVTVSSRITGEIGSSSNPISGMTVATILLTCLIFLAIGKVGIEARVVALSVGAVVCIAAAIGGATSQDLKTGFLVGATPRQQQIGLVIGVTTSALAIGWVLSFLNDSNTIYFPKEAPGYTATATENRTVTLAGKTYRIHNVTEPAAGLLPGRYLINDAGQIRFIIDPGVGGIETRQLVETTGPIQGTDTGRTLRGLDDQTYRVVQVATSPEVVVEYLVDEQGQAHYRLDRRDLPYSAPKASLMKLIIDGILTQKLPWGLVLLGMFISITMELCGVAALPFAVGLYLPFSTSAAIFVGGFIRWLVDRQTGGAVSEAEAEAGSGVLFSSGLIAGGSIGGLLLAALTVVAGGFLTTLNVAEHFPALEHGAFADAWAVAVFLLLGIGLYRVARSSPVGTKS
>NC_016024.1|WP_014098998.1|583139_584327_-|hypothetical-protein
MNTYLSVWRIVAGVAIGIGCLWLGAGIASGPVRAAGIVTRDNVPFNYAEDRLLIYYDAAAKRETVVFEPAIRFRGEAFAWAMPFPGEVQLAAAGPQIFLRLSEYLAPTLIETRRRWKLAFWLWEWFKPKPVVKPSALPRPQPGQIVVARRVAEASIETLPRATKEELTKALQKAVARRPEETPFDPTKPPTPEKPLQLSESFLAWAKPHLDQKATWVIVTARTDPADTALGYDEQASIQPFVVSFTTEQPVVPLTCPAPFPALEDVPKHRNFKAFIVTRERTEVRADGTLLFEPAAVPFADRIPAADWTKRVLAPTQPEFQPAEDTFLTTYFHTERDQRVFQTNPVIVPATTQTTIRPPANIVVQEQPVIIPGEALLLILGGGLVYWRQRQREQR
>NC_016024.1|WP_014099009.1|598559_599513_-|hypothetical-protein
MSNVAEAASQRSEAASLPWRFYLGWGLAALLGLVWLAAGVIKALEPFDFVRQVAGFQLVPGKAMQTAIAWGLLVAECALGAALILGYRLRWALVGAGCLTLIFMGALGWVILAGIPVEDCGCFGSQVKRSPKEALLEDSLMLLVTVVSGWLVWKPQATVTALQPRRWRGLGVLLCALFGLLTPLAFGFPLGGSDWSRVKVSGTTVNVATGERLVALIDTECSHCQESVPQLNAYVGVKDFPLFVALCSNEEWRRKFFIQRFGAKFELGEISKEDFKRLLADGDTPRIVLLRQGKVLAVWNGTPPSPDEVRRARAKRP
>NC_016024.1|WP_014099010.1|599509_600079_-|ubiquitin--protein-ligase
MTVFMATPDDVRRARLAADYEEMRTIRGEYIHWQNLNVPATDYIVTLRIRSYIGPNTTRDEHQIRILLSPNHPFEKPTVMMHGMTPIFHPHVWPDGKICIGHWDFREGLASFVIKLARLFQFDPQLIDPHSIANYKAADWFYANPTLFPCDQAKLPVPGEKPTHTFVVKRITPPRPTDVRPGGRFQIRS
>NC_016024.1|WP_014099011.1|600190_600967_+|bifunctional-demethylmenaquinone-methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol-methylase-UbiE
MENPIAFQGSEKARRIQAMFAGIAPTYDQLNHWLSLNIDKRWRRAAVREVQDVLTRPGARALDVCCGTADLALELGRLAPTVGVDFCQPMLLRGMEKVRQSGRPVHLLAGDALALPFADASFDVATVAFGIRNVVDLDGALAELYRVLKPGGKVAILEFSHPVVPGLKPLFGFYFTQILPRIGNAVSRSGYAYSYLPASVQHFPDQPTLAARMEQAGFQQVKWRNLSGGIAALHTGVRPAVTNPVSADPVSTGVDADR
>NC_016024.1|WP_014099012.1|601003_602587_-|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase
MTLPLPPRALLSVSDKQGLVDFARTLHAHGLELVSTGGTAQTLLEAGISVLDVASVTGFPEMLDGRVKTLHPRIHAGILARRDLPEHLEQLALHDISRFDFVVVNLYPFADTIARPEVTFAEALENIDIGGPTLIRAAAKNFQHVVVVTDPADYAALAAELTHTGSISAATRYRLACKAFAHTARYDRMIADFLANRTQFEEATGQVQLQPPDAFPPRLSLVLHRQQALRYGENPHQSAALYVPAEHPAGGLAAARQLQGKELSFNNLLDADAAWGLVGEFRDAAACVIVKHTNPCGVGLGAVPLEAFRLARETDPVAAFGGIVAFNRTVDAGTATELSEIFLEVIIAPGFDDAAQKVLAARKNLRLLVVADEARPAADFRTISGGLLVQSPDDRLATPDEMRVVTRRSPSEDEWRDLLFAWTVCKHVKSNAIVYARQGQLLGVGAGQMSRIDAVRLGAMKACLPLSGAVVASDAFFPFRDGLDEAARHGARAVIQPGGSIRDEEVIAAADEHGLAMVFTGMRHFRH
>NC_016024.1|WP_014099013.1|602735_603968_+|prepilin-peptidase
MFVSMVELHDSLPLWFWAIWAFVVGSCIGSFLNVVIYRLPRGGSVNSPPRSYCPSCNATIAWYDNLPILSFLLLRGKCRACGVRISWQYPLVELATGLLFLTALLVFGPTLQCVFNCAFAAALVALIVTDFNEQILPDAITLPGTALALAARLLDHNLVGLPWMNLFFEGLTGWPLPMTGLAGSLVNALLGMAIGAGALWVLGVGYFRLRAFPIRTPDDLADFLKRRCVVGTLARLKLRHANGKRGVVYVLGGDFSELSPEELAAAEFASSNTGTPELSMTALDGACVEPGERGVRITSIPDALENTVDGQLEPGDTIVSGNLEGMGLGDVKMMLFVGAFLGGGLTFFVLLMASLLGVLVSLPRLLLRGSSALQHALPFGVMLGLAALVALFCGEKGLTTYLDFLSSFIS
>NC_016024.1|WP_014099014.1|603975_605076_+|phenylalanine--tRNA-ligase-subunit-alpha
MPDASTLNASTLQSVMADAHRRLAATFGERFPEWTLPDFELPTSIPPRRQWQAVNDYWLARRQGVLALKLKELGALPADQRPVQGAALNRFKAEVEAVLSDLEAQVRAFEEAETIRREAVDVTLPGLVRRRGRAHPLTQIRERIEDIFVAMGYAVEDGPEVDTVFYNFDALNIPPDHPARDLTDTFYLDDELALRSQTSNVQIHAMQRRKPPLRIIAPGRVFRRDEPDATHNPMFFQVEGLNVAPGITMGDLKGTLQVFLTRLFERPVTLRFRPSYFPFVEPGAETDFQCPFCGGSGCRICKHTGWIELGGSGMVHPNVLRACGIDPTEFSGFAFGFGIDRMAALLYGIDDIRLYFENDLRFLSQF
>NC_016024.1|WP_014099015.1|605108_605651_+|hypothetical-protein
MKCLLFLLLTGSLGLFGGPAQTSAQTSAQAPASAPTPDRQQLRVWQGRYPHHDVRGPRGRVQKISFFKLPALRKPLAEMLGEDFLDGVEQGNYLEEPIELFGDYLLVRLYPNLRRIEDEHRLIIVVPLEGTALHAVYYQEVVGADGQRDIQTDWRHSFGTSLDDLPESLKTRLATIMGLP
>NC_016024.1|WP_014099016.1|605660_606686_+|threonylcarbamoyl-AMP-synthase
MKATRTPVLTERILCHPESPEPEAIARAAALLRQGELVAFPTETVYGLGALAFDADAVAKVFAAKGRPSNNPLIVHIAGRDWLEWVAVAIPPVAHRLVETFFPGPLTLILHKHERIPPVVTAGGATVGVRWPAHPVAQALIRAVGAPLAAPSANRFTEVSPTTADHVLKSLDGRIAAVLDGGPCPVGIESAVLDVTTTPPTLWRAGILSQAELEAVAGQPFQRPQPGAVVASPGQFPRHYAPRAHVELVLPGDVPNIEHRLARWLAQGQRPAALVISEVTPPAGARLLRLPAQPEAYAHRLYAALHELDAQGVEVIVIEQVPADPAWDGLRDRLHRAAGKP
>NC_016024.1|WP_014099017.1|606792_607746_+|bifunctional-riboflavin-kinase/FAD-synthetase
MDIFHDWQSPALRTPTVLTMGVFDGLHLGHQTIIRRVVERAAALDCIPTVVTFDPHPRAVLHPDAAPPLLQTLGQRLEALRILGIRQTLVLRFDPALAALTAAEFAQRILFGALGAREIYLGEDFAFGRGRQGNIATLRCLGADYGCAAYEVEAVLLRGKRVSSTRLREAIQSGRINLARRMLLRPYGVEGEVVTGRRLGRTLDFPTANIAVINRVLPADGVYVTATLIGGVWRRSVTNIGYRPTVSDDRLRVVETHILDFGGDLYGTSLRTRFLHRLRAERKFASLEELRAQIAYDVARSRRYFRHSGVRRSLAVE
>NC_016024.1|WP_014099018.1|607786_610285_-|hypothetical-protein
MHQVQRFFRHWLLWTMCLWLTPVDVPAQEFADFGLVRSTISVTLRPAEYSADVTATLELTNIARQAEARTLTLRLTKAAKVTAFTVNERAFSTDEKKQPGGDAAIATYVAELSPPLAPGGKVTARLAYTLTYRESTSYAAITPGDTLLLPESGWTPFIHLPQSSHGPDTAPYVLTVARPPDGEVWSSGTRRETDDAIVFTSDLAGEPWLVVQPLGPPVSRRVAADNGESVTIHVRSAQGLPAETQRQAQRLAEEVERILAFYQKLWGAAPVREFHLLTTPRRVVADRRSPELRGRDFDTDRAIRYAAPGAVLIEAAALRRPTLDAEMVEWLTASLAQTWLGGKVRLRGRGWGILADALPAYLTGRYIEQHYGPAAGRDFWLRRSFAYGRLAAIRVSQQGFERGIDLIPVLQHPAFPDYYASMPNRGALVFRLLERLVGRDTLLTAIRETVADPGGTATYEAFRNRLVGTPPDERRANFFRQWFEELSEPDFVIGVPVRREDGPGWTCALRNLGTGDASLPVVAITDKGERLTTTVELPSKGYATAVFETPATITSVELDPEKLYPQVRFGYDRNSRQFDNDARPERRYAFGLLLDAEATLTRRLKAGETEAQRQAEAEGLLREALAREPDLALARAYLARTLIAQGKPDAAAEQVAAIRRAALPSRYPLALALLTEADLAMARQAYEQARAAYKAAFEMESGPALDEQARRGLLASETAAGQASPPDEELRAFLATMDKAIRTGTSKALEACFIRPDTSRFVLGIVVSKPDAWTTQGLRMERLDARRVLLDVRVVVVSATKEEQTGTGLIFLRRVGQSWMVERLDQFVLAKR

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Crispr_ID: NC_016024_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016024_5

2481632-2481720

Orphan

Consensus_repeat	Method
ATTCAACCGTCGCTACGCGACGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_016024_5

>merge|NC_016024|5|2481632-2481720|CRISPRCasFinder
AATCAATCGTCGCTACGCGACGGGGGGATTCCAACCCGGCGGTGTGGTGGGTTGGTCACGTGATGATTCATCCGTCGCTACGCGACGGG

>NC_016024|5|4|2481632-2481720|CRISPRCasFinder
AATCAATCGTCGCTACGCGACGGG	GGGATTCCAACCCGGCGGTGTGGTGGGTTGGTCACGTGATG
ATTCATCCGTCGCTACGCGACGGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_016024.1\|WP_014100568.1\|2474028_2474505_+\|IS200/IS605-family-transposase	unknown	unknown	gnl\|CDD\|376616
NC_016024.1\|WP_014100575.1\|2489369_2490947_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274272
NC_016024.1\|WP_014100565.1\|2471266_2471512_+\|hypothetical-protein	unknown	unknown	unknown
NC_016024.1\|WP_014100577.1\|2491948_2492248_-\|hypothetical-protein	unknown	unknown	unknown
NC_016024.1\|WP_014100574.1\|2486407_2487880_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226957
NC_016024.1\|WP_014100564.1\|2469242_2471132_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|274350
NC_016024.1\|WP_014100561.1\|2465391_2466477_+\|UDP-3-O-(3-hydroxymyristoyl)glucosamine-N-acyltransferase	unknown	unknown	gnl\|CDD\|234858
NC_016024.1\|WP_014100578.1\|2492529_2492760_+\|AtpZ/AtpI-family-protein	unknown	unknown	gnl\|CDD\|378198
NC_016024.1\|WP_014100562.1\|2466480_2467068_+\|hypothetical-protein	unknown	unknown	unknown
NC_016024.1\|WP_014100560.1\|2464783_2465395_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|369777
NC_016024.1\|WP_014100573.1\|2485726_2486398_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NC_016024.1\|WP_014100563.1\|2468216_2469230_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293817
NC_016024.1\|WP_187288374.1\|2475384_2480349_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|271342
NC_016024.1\|WP_014100572.1\|2484173_2485541_-\|GTP-binding-protein	unknown	unknown	gnl\|CDD\|349766
NC_016024.1\|WP_014100566.1\|2471488_2473054_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293836
NC_016024.1\|WP_014100571.1\|2483054_2484128_-\|WD40-repeat-containing-protein	unknown	unknown	gnl\|CDD\|238121
NC_016024.1\|WP_014100579.1\|2492769_2494122_-\|FAD-dependent-monooxygenase	unknown	unknown	gnl\|CDD\|223727
NC_016024.1\|WP_041569203.1\|2473052_2474039_+\|TonB-family-protein	unknown	unknown	gnl\|CDD\|367555
NC_016024.1\|WP_014100576.1\|2490956_2491952_-\|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	unknown	unknown	gnl\|CDD\|234626
NC_016024.1\|WP_014100580.1\|2494244_2496284_+\|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme	unknown	unknown	gnl\|CDD\|270916

Protein	Function_ID	Function_description	E-value
NC_016024.1\|WP_014100568.1\|2474028_2474505_+\|IS200/IS605-family-transposase	gnl\|CDD\|376616	pfam01797, Y1_Tnp, Transposase IS200 like. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.	3.57995e-37
NC_016024.1\|WP_014100575.1\|2489369_2490947_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|274272	TIGR02733, similar_to_to_phytoene_dehydrogenase, C-3',4' desaturase CrtD. Members of this family are slr1293, a carotenoid biosynthesis protein which was shown to be the C-3',4' desaturase (CrtD) of myxoxanthophyll biosynthesis in Synechocystis sp. strain PCC 6803, and close homologs (presumed to be functionally equivalent) from other cyanobacteria, where myxoxanthophyll biosynthesis is either known or expected. This enzyme can act on neurosporene and so presumably catalyzes the first step that is committed to myxoxanthophyll. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	3.89154e-104
NC_016024.1\|WP_014100580.1\|2494244_2496284_+\|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	6.99161e-109
NC_016024.1\|WP_014100574.1\|2486407_2487880_+\|ABC-transporter-permease	gnl\|CDD\|226957	COG4591, LolE, ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane].	4.13764e-11
NC_016024.1\|WP_014100564.1\|2469242_2471132_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	5.02474e-20
NC_016024.1\|WP_014100561.1\|2465391_2466477_+\|UDP-3-O-(3-hydroxymyristoyl)glucosamine-N-acyltransferase	gnl\|CDD\|234858	PRK00892, lpxD, UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional.	2.54847e-152
NC_016024.1\|WP_014100578.1\|2492529_2492760_+\|AtpZ/AtpI-family-protein	gnl\|CDD\|378198	pfam09527, ATPase_gene1, Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter. This model represents a protein found encoded in F1F0-ATPase operons in several genomes, including Methanosarcina barkeri (archaeal) and Chlorobium tepidum (bacterial). It is a small protein (about 100 amino acids) with long hydrophobic stretches and is presumed to be a subunit of the enzyme. It carries two transmembrane helices and is a magnesium or calcium uniporter. The atp operon of alkaliphilic Bacillus pseudofirmus OF4, as in most prokaryotes, contains the eight structural genes for the F-ATPase (ATP synthase), which are preceded by an atpI gene that encodes a membrane protein with 2 TMSs. A tenth gene, atpZ, has been found in this operon, which is upstream of and overlapping with atpI.	7.61103e-08
NC_016024.1\|WP_014100560.1\|2464783_2465395_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	5.76917e-13
NC_016024.1\|WP_014100573.1\|2485726_2486398_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	4.49812e-91
NC_016024.1\|WP_014100563.1\|2468216_2469230_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293817	cd07731, ComA-like_MBL-fold, Competence protein ComA, ComEC and related proteins; MBL-fold metallo hydrolase domain. This subgroup includes proteins required for natural transformation competence including Neisseria gonorrhoeae ComA, Pseudomonas stutzeri ComA, Bacillus subtilis ComEC (also known as ComE operon protein 3) and Haemophilus influenza ORF2 encoded by the rec-2 gene, as well as Escherichia coli YcaI which does not mediate spontaneous plasmid transformation on nutrient-containing agar plates. It also includes the phosphorylcholine esterase (Pce) domain of choline-binding protein e from streptococcus pneumonia. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. .	1.44652e-77
NC_016024.1\|WP_187288374.1\|2475384_2480349_-\|hypothetical-protein	gnl\|CDD\|271342	cd14948, BACON, Bacteroidetes-Associated Carbohydrate-binding (putative) Often N-terminal (BACON) domain. The BACON domain is found in diverse domain architectures and accociated with a wide variety of domains, including carbohydrate-active enzymes and proteases. It was named for its suggested function of carbohydrate binding; the latter was inferred from domain architectures, sequence conservation, and phyletic distribution. However, recent experimental data suggest that its primary function in Bacteroides ovatus endo-xyloglucanase BoGH5A is to distance the catalytic module from the cell surface and confer additional mobility to the catalytic domain for attack of the polysaccharide. No evidence for a direct role in carbohydrate binding could be found in that case. The large majority of BACON domains are found in Bacteroidetes.	5.99332e-16
NC_016024.1\|WP_014100572.1\|2484173_2485541_-\|GTP-binding-protein	gnl\|CDD\|349766	cd03112, CobW-like, cobalamin synthesis protein CobW. The function of this protein family is unknown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterize it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage caused by mitomycin. YijA gene is a homologue of the CobW gene which encodes the cobalamin synthesis protein/P47K.	1.15025e-102
NC_016024.1\|WP_014100566.1\|2471488_2473054_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293836	cd16278, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily.Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	7.34585e-44
NC_016024.1\|WP_014100571.1\|2483054_2484128_-\|WD40-repeat-containing-protein	gnl\|CDD\|238121	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.	3.49435e-33
NC_016024.1\|WP_014100579.1\|2492769_2494122_-\|FAD-dependent-monooxygenase	gnl\|CDD\|223727	COG0654, UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion].	5.66226e-47
NC_016024.1\|WP_041569203.1\|2473052_2474039_+\|TonB-family-protein	gnl\|CDD\|367555	pfam03544, TonB_C, Gram-negative bacterial TonB protein C-terminal. The TonB_C domain is the well-characterized C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance.	4.89121e-11
NC_016024.1\|WP_014100576.1\|2490956_2491952_-\|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	gnl\|CDD\|234626	PRK00091, miaA, tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed.	7.49182e-130

>NC_016024.1|WP_187288374.1|2475384_2480349_-|hypothetical-protein
MSGLGAGPGSADRSFGYASGGTGAFQMTDLLNRIGVNIPEPGEIRAIAVQRVGANANKFIVGGNFVYRVPGTNQVYRNLMRLNPNGTVDISFVPGLLIPVVNALVVQSTPLLADRIVVGCETAPQLFRLLPNGAQDTTFSPPPLTPPTVAVLALEVEPLLLPPSVPNPTADYIYVGLNGGTIGGRTNLARLLPNGGPDSTPGTFWGPQTAPAVQVSVNGPVRAIKFADRLGGLGLPGIVVGGAFNLAQGGPFPPPPSFECLNVAFFPTDGDFFSFSVGFFTNFFKGFDGPINAIAVSVSPANVSEIFVGGEFGNCVTFASPPNVARPRVAKFSFFAGLDTVFNPNPATSVPNPVRALVLTGGPPNFTAPPPSPPLPPPPPLLLSVLHVGGQETTTAFADVALSPVTGGLVVDVDPITPGLQPTFFTRSPFFPANPAVVRAMAANNQPLPNGGALFGGAFLNATVYGQNLNAPAQKLVATFTNLYSPPSPLGPVFSLPPPPPPFGPNPGTLPGFVALGPTQFYASALLPNGDLLIGGDVGVNGNASLPASLDDLEAVLYRIDPCGTVNVVARFRNISGYLVRNDVDNGTFVSPPQDINITPGQGFRRVDFVDPPSIRAIAVDSAGNIYVGGQFNRVSDGPGGPFQPWNNLIRLKSDGTIDPLFAPGAGLTSYAPGYPVMRLGGPTGFGTAGVGFTTVDPQTALPALTGNCDATPTPPVTGTGEKFNPNEGRVNAIVLQPNGRILIGGEFKCYNGIPRGGLARLLPNGSLDTSFGDPLAPLPGVDDYSLCDDPIPPPGVPRTNPAVAYNRARVNAILLQPDGSVVVGGLFGKANGIARYNLARFDSAGFLDLTFSSGPTSTVFPTGTAGVGGGGSGATSNGRGGEIFALARQSLGPNAGRILVGGVFTTILNQTGAPGNLPRTAFTRFETNGRHDATFAQLNFTAAGTVRAIALQADDRPIIGGSFRIGPGTAGGTQYTSNTTRVRVFRCGVNGAFTDTVDSLNIPRSSWLAVQPPPGVTVPFQPGPYAVPGVGSLASVFAPTATLPEINYYPGGSVSPAFGTGFFNATNVAMAVNTIALDPTRRRAYIGGLFNVFESARADFQNDNAGAPNGLSLDIRWPGVAALQTGCTYGLVAPTFPPFTVLPAGGTVNLGAINPAGGNLTIGSLTRSAVSVCDALPTVSTGSTFVTIVGVVPRTAGPGPSFADIIINVSPNNTGANRTGSVTVTLPSETSTSPPPTTFTFTQGPASGCTYTATAVPASFPVAGGTGQFQITTGAGCTWTITGLPTWISASPLSGSGSSTVNFTVAANTGAPRSATVTVAGQNITITQAGTCTLTLGTATGTSLPVTGGTGSFTVTTLAGCTYTATSSAPWLVITGGASGGPTGTVTFSVGRNSGAARSATITVTAPGVPAQTVTVSQAPDLAGPDTVGMFRSSNGFFYLRFSNTSGNADTDFFYGTAGDVPLSGDWDADGVTTIGIFRNGQFFLRNSNTAGFADVPAFAISGTQPGDIPLAGDWDGNGSTTVGLFRAGVFLLRNSNTAGPADVVINYALPTDTPIVGDWDGDGVTTIGLFRASVAFFGLRNSNTAGPADLQFFFGAPNDVPVAGDWDNDGVTTIGVFRAGTFFLRNSNTAGVANLTVNYGLATDRPVIGRWQ
>NC_016024.1|WP_014100568.1|2474028_2474505_+|IS200/IS605-family-transposase
MTGSVEGVTANTYSSLFYHVVFSTKQRTKFIRPEIEQRVWAYLGGVASRQGAKAVQIGGVEDHVHVLLMAPPTVSPAELVSRIKGDSSRWIHEVFPELRNFGWQDGYGVFSVSRSNVPQVVKYIQNQREHHRVRTFQEEYLLFLKKHQVAYDERYLWG
>NC_016024.1|WP_041569203.1|2473052_2474039_+|TonB-family-protein
MVNQRAPVWPQRSQYTLGAHHVTYCWLWLLLVGLWGGCLWALPAGARPLPAGLFVSDEPLTVAVLPPDIADDVGGVTSEGLLAALEQALAREGLEVVPRAQVFAAVPAGRPLDFNPTCTAAQALGARVGSEGYVLVRLRRGERSLSDRQTIVGGTLHLFAVETRTGQLVASEHVDFIEGKEGFLPAVAAGIEAAAQRFASDWRRVRGQTPGMGCAAGGDGADEVLDLRDGVLPPGVTAPVPLVRARPEPTGLARAAGVTATVMVEVCVGRDGQVREVAVVRWAGYGLEAAVEKALRAVRFRPALRQGKPVAAWFVAAFNFRSSPADDR
>NC_016024.1|WP_014100566.1|2471488_2473054_-|MBL-fold-metallo-hydrolase
MTSVVPKYASAVILLRRNETGDWRFFWARRAQAAPFLGGYHAFLGGRRDPEDEQVPVRHATDPEHAAQCACAVREVFEEAGILLAESRLTAPETRLAVRADLMAGRLTFAEVCARFAVEIDARRLIPGGRWVTPVGVPRRYDTTFFVSRLDGADEPELWPDEMVDGQWVTPAEAMAAWAQGAVRLVPPTLHSVRSLLRWTTEGFAGREDFQRLRELLHDHPAAHGEPPAFIELAPGIVTFPVRTPTLPPATHTNCYLVGDRELVVIDPASPYPEEQARLDAHLTWLAEQCGARVTAIWLTHHHPDHVGGAAHLSRRWNVPVAAHPITARLLEGKVQVSQWLADGDGQFIPASPAMGRWSTTPPGWPGWRLRAVFTPGHAPGHLCFFEETTGTLLSGDMVVGLGSVLIDPDEGDMAAYLASLRRLQTLPVQLIAGGHGPALGEPQAVLAAYLAHRQQREESILAALRSGATTVADLVAVVYADTPAALHPLAARSVQAHLVKLTREGKVQQSGGRLQLADVA
>NC_016024.1|WP_014100565.1|2471266_2471512_+|hypothetical-protein
MKPVICTFCNSEIYTYVGPEPVELKAVHFKPTRPGWGAPKPGDPLYCPVCGSRFVGVSVQNKQLRMVVSSEYAGSGNVGKL
>NC_016024.1|WP_014100564.1|2469242_2471132_-|tetratricopeptide-repeat-protein
MVNIQKFAAHRHWPWLLAVGLAGLVYANTLGNGFTYDDTPIIVNNPTIRSLADVPRLFLTGYWEHRQSGGNNYRPMLATTLAVDYALWGLHPVGYHLTNLLLHAANTAWVWWLLRCYRAAPWLALLAALVFAVHPVHTEAVANVVGRAELLGMCFGGLMWWSWVQARRNAEHAGRWRALAAAAYLAAMLSKENMVVLPAALWLAEVLRVRRHLWRAGWSAWWITTRPFFWLAIPWLPYAGLRLVSQQGFQPTGALSGNPMYAQTLWERLVTMAGVSLEWYRLVFLGFPLKPWYDAHNLALTPVWSWRTGLGGLVTLGLVVGAVAAVRRFPLLTFAVGFWFITLALVSNIIAPLWTPLGERWLYVPSVAYAIAVAWVLVRLGGMTSQQPAAAWRVGVSVGMALVLFIGYAYGTSRRNLDWQSDWRLFTRFLETDPQHPLPYTSLAHAWQTTDPAQARAYYEQALARVPNFFLALLGLAQLDLREGRIEAAHARLGQMVAAKPPEVVPTDADWGLVHALYARTLALQGDTAHALEQIAEARRYGPRDTPTLTSCAIAYVNLGQIAEAEAILREALDLGVDTPTIRFNLGSVLLRQGRTDEAERHFEAALRLDPDFAPARLARDKLQPAGTP
>NC_016024.1|WP_014100563.1|2468216_2469230_+|MBL-fold-metallo-hydrolase
MRKDRRSSSARRGWQGCLLVVGLLGLAAASLWLLWHFRDRLIPGPPPLAGKLLHIHAIDVGQGDSYLIVTPEKKTILIDAGPAEAGSKVVAFLRQQGIAELDLVIATHPHADHIGGMGYVLESFKVKNFLDSGQEHTTLTYRRMLEAVKKHVGRLTLAQAGQKFNLDNGITLSVLGPRQPWLQNVSGSDLNANSVVVRLDYGQFSMLLTGDAEDETEDRLLTDGAPLQVTVLKVAHHGSRHSTRERFLRAATPSVAIISCGATNRYGHPAQATLDRLRRLDVALYRTDLHGDITLTTNGQEYRITPTRQVAASELWRGRQPDTANDSGDEMPRRRAG
>NC_016024.1|WP_014100562.1|2466480_2467068_+|hypothetical-protein
MMTVHRFCFQRYGIALLAALVLLAMTLPGRAAAPVAFTSAYTDLNLRCRYDNTGASEGSDAPMYCTGYGNYRLLVSFSAFAADIFVEARNRSFSRLLAEGQAPGYTREKGRKAEWRLADGKPFAVILRAFTYRTGPDDAPDFSRKVGERLVIKGLAGFEHIDFTVDTRATPNANLRARQLADDGYSAVGRAGVSW
>NC_016024.1|WP_014100561.1|2465391_2466477_+|UDP-3-O-(3-hydroxymyristoyl)glucosamine-N-acyltransferase
MNHLPSAPTLRDLAAAFGYTVEGTADAAEIVITGVAGLDEAGPTELTFLSNPRYAAKARTTRAAAIIVSQGVATEGLPCPVVRAPDAYLAFARMAGWFYRPPRPSPGIHPTAIIAPSARLGAEVSVGPYVVVGENVVLGDRVRLFAHTVIYDGARIGDDSVLHAHVVIREQVELGCRVTVHNHVTIGCDGFGYAKRPDGSWEKIPQAGRVIIEDDVEIGAGTQIDRPSVGETRIRRGAKLDNLVQIGHAVEVGEDTLLCAQVGIAGSATIGSRVILAGQVGVAGHLTIGDGVTALAQSGIPNDVPAGQQVAGYPAVDRRQWLRVSAAQARLPDLLKHVQHLEARLKALELAAREKDPSRKG
>NC_016024.1|WP_014100560.1|2464783_2465395_+|class-I-SAM-dependent-methyltransferase
MPDVLAQWMARLAGQRVLDIGCGRNKTPGALGMDANPHADADLVHNLDDVPYPFPEHAFDAVIGRHVIEHVQSPLAVIIELHRIVRPGGWVLLVAPHWTNPDFATDLTHRNHLNSYSFRNLTVGQEVFDFYAPVRFRQRPPYVTLLNLWRACGLEWLVNLDRRHPRWRFLRRFWEQYLNAVVRGKEVYFELEVVKPDGTPPAP
>NC_016024.1|WP_014100571.1|2483054_2484128_-|WD40-repeat-containing-protein
MRLPSIAAFLKGATRQLEVDWQAVLDDGVVALEWAPDGGHLAALSAAGTLTVWDGATGEQRWSCAAHRTGGMTLSWSADGTVLATGGQDRQVCLWEPTTGDRLVSLPAGAAWVERVAWSPPYQDGAPAVLASAAGKVLRFWTPTGDLISEHVRHTSTIADLHWHPQRRCLVTACYGLLTVWTPGADLPAEVFAWKGSHLAVRWQPQGRYLVVGDQDATVHVWDVTTGEDLVMSGYMIKVRELAWHPAGRFLATGGGAAVTLWDFAGDGPAGSTPIVLEGHSGLVTALAYCPDGGVLASGAEDGVLVWRPPEKPGRTVSPVGRYDVAGGVACLAWRSDGARLAAGGLQGEVLVVVVAA
>NC_016024.1|WP_014100572.1|2484173_2485541_-|GTP-binding-protein
MSSAGTQAAPQRVPVTVLTGFLGAGKTTLLNRLLSEQHGKRIAVIENEFGEIGVDHELVIEAEEEIFEMNNGCICCTVRGDLIRILGSLMKRRHKFDYILVETTGLADPGPVAQTFFVDEEIQRQTRLDGIVTLVDAKHVWEHFDTNEVQEQIAFADVILINKTDLVDAATLERLEQRIRAMNATANIRRTQHANAPVEALLDIGAFDLDRALAVDPQFLEPEYPFEYGGLYALTAGEATLELQPGPDPTLDLLFLPAPEGADDPLAALTDRAIVLFSEEPEPVTTGHRLTPEPRLRQLRLAADGPTRLTLDVPQTGHYVLLTQHHPEEFAAVLRQGGREVAPLHSRAYKPDHEHDAEVTSVGIKLPGDLDPKRLNAWIGELLQTQGPDIFRMKGILSLAGDPRRFVFQGVHMVFDGRPDRPWGAEPRHNALVFIGRHLDRAALEAGFRSCLVSS
>NC_016024.1|WP_014100573.1|2485726_2486398_+|ABC-transporter-ATP-binding-protein
MSLLQIRQLRVQYPGPDGEPPTPVLDIPDWGVAAGEQVALVGASGSGKTTLLHVVAGIVLPDSGEVRLGDTDITRLDEASRDRFRAANIGYIFQQVHLLPAFTALENVLLGMTFADNRAGTAEALALLESVGLRERARYFPRQLSAGQQQRVGIARALANRPRLVLADEPTSALDARHRDAVIDLMQRLCQDIGAALVVVTHDEAVARRFPTTIRLADINHVK
>NC_016024.1|WP_014100574.1|2486407_2487880_+|ABC-transporter-permease
MHTLTVIYRNLRQRWLSTGLTALSIGLGVALVTAITALRQQAQANFDNVAASYELVVGAKGSPLQLVLNTVFHLDVPVGNLPYSYYRKLKADDRVAYAIPLALGDNYRGFRLVGTEPEYFNLVRLKDGQPVAVAQGRPFAADYEAVIGSVVVRETGLGLGQTFVARHGVEDTAAAEEHEDAPFTVVGILRETGTPLDRVIFISLGSVDEIHQESRDKGGKSLLEQLEALPAEPSGSPPEDRPEDRNDHDHHHHHRKKPAAPPVGDTPGGDKPAVLPGQTTSAPAAPNQAAVGVPGQAIDEVTAIIVKLRSPGYLFLMHREINKGKDAQAALPGVEVQKLFTIVGTVDRALLLMSVLVVVVAAVSVLVAIYNSLAERRREVAVLRALGAHRRTVFGWLVWEAAMTAALGGVVGVLLGHALLAVAGSSLKFLSGLPLDPWRWTRLEVGPAWLTAYVPFEVAVIAGTLVLGAVMGLLPAALAYRTNVARHLSE
>NC_016024.1|WP_014100575.1|2489369_2490947_-|FAD-dependent-oxidoreductase
MRPLAETTFDVVVIGAGVAGLTAALLLQHDGYRTLLLEAHDKAGGCAGYFFHKGYNFDVGATVLMGLDPAGLHTQVFNRLGWPLPESTLIKQVDVHLPDRCVHIAHNPEIWAHERVVRFARTPEEAERLRAFWQLVDRTADTLWTATAKLPVLPLRHWRDVVANLRLVSPDFLRAAPYLFSTVEDVLRRYRLADHAPLRAFLDGLLLITVQETAARAPFLNGAAGLDIYRHGIRRARGGMKSFIKAHVAAFRELGGVLRLRQRVTRITPAAGGGYTVETDRGLTVHAPRVVANLPIWNVPSLVAADVSRQMKRPLNKAGVGWGAFTLYLGVRAEVIPDDTPLNHQVLLEYGAPLDDGNSAFLSLSEVDDRASAPPGRRTLNLSTHTEVSPWWELSPEDYAARRAAVVERLLTAAERVFPNLREGIECALPGTPRTFARYTGRAQGMVGGLRTTLWNSNLFGIGSRDVGLPDFWLVGDTVFPGQGTPACALSGINAWRDIGMRVSRPQAWERGRPARMKQIAFNRY
>NC_016024.1|WP_014100576.1|2490956_2491952_-|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA
MTPRPIPVIVGPTCSGKSDLGLAVARALDGEIINLDSIQVYRGLDVATAKVPPALRALVPHHLIDVADPAEHYTAGRYAREATACLADIEARGRTAVFVGGTGLYFDALRGRLFAEDNPTDLRLRARLHAIRARRGAPWLHRMLRRLDPATAARLQPNDWSRTMRALEFFLCTRTPLSQRQRQLAPPPPFVARMRLLVLSPPRAELYARINARVEAMVAAGLLDEIRRLLAAGVPPDAEAFQAHGYRRFIEYLRGERTYASAVEQMKTDTRHYAKRQLSWWRREPEAHWLAGFGSDPEVQRQALELLRAPAPVRPGTQLAGELPTSASPSL
>NC_016024.1|WP_014100577.1|2491948_2492248_-|hypothetical-protein
MAQRQHFEYQIGDEVSFAAGHGMQYGEVVRIITPGPDGAIEIQWEDGRREVKKTRDRAIHLVRRASGISEVDERRGQRRRSTDDEIAEVRRSDIRRRHG
>NC_016024.1|WP_014100578.1|2492529_2492760_+|AtpZ/AtpI-family-protein
MPSPQNSDNDEAAQRARMLTAAGLALGLPMTILGSFLVGYWLDRQLQTAPLWFFLLGIAGLVSSARLLYRLWEQLR
>NC_016024.1|WP_014100579.1|2492769_2494122_-|FAD-dependent-monooxygenase
MSDELMVAPSFTVCGAGLAGTLAALYLARQGNRVTLYERLPDMRTHSVPRGRSINLALSRRGLHALEALGLAPVIHPLTIPMRGRMIHSLQGELTFQPYGRTPEETIFSISRHQLNCALLDAAAHWPNLEIHFQSRCVGLNLSSMTLEIEDTRTRTVRQVSARTVVGADGAFSAIRQALQRTDRYDYAQTFLPHGYKELTIPALPGGQHALEKNYLHIWPRQDFMLIALPNLDGSFTCTLFLAYEGAESFASLTDEDAIRRFFDRHFPDVTPLMPTLVEDFQHNPTGSMVTIRCFPWQYAGRVVLIGDAAHAVVPFYGQGMNASFEDCFVLDECLRRHNGDTSAAFLDYQQQRKVNTDALAELAYENYLEMRAKVASPWFLMRRRLEYALSNLLGDRFLPLYTMVSFTRIPYAEARARAARQDRWLDAALATLALLVLLALLWWLWPAGR
>NC_016024.1|WP_014100580.1|2494244_2496284_+|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme
MKQCPACGQQYEDNVTFCPVDGKGLIPLLIDGKYRIEKKIGEGGMGQVYRAIHVEIGTPFAVKVLHAQFGEDEKAVARFRREAQAAAQIRHPNAVSVTDFGVTKDSNLVYFVMEYLEGESLGERLRETHALPMEDIHFIYSCVCSALHAAHLKGIVHRDVKPDNIFLLLDEERNIKDVKVLDFGIAKLKRQDKNTLTASGTVIGTPDYMSPEQCQGLELDARSDIYSLGVILYELFTGRVPFQSESAMTTLMAHVSQPPPPPVTINPAVPPGINRLILRTLAKQPHERPETALHLLGELEQALQEAGVQLGTASMTNLLKTQRHVGRSTVGGSKAPTTDVTEGTPTTNRTLALSGANIAVERATVESQRATGLNRKSTSEPGGETKTYVAVDGKRAVGARLWLPFAAVVGLVVVGLIAGGGWYLSRRAATAGQGATNLDSPKPPPAPPGMVYIPGGTFIMGNNASADDFEKPEHERQVAPFFMDRTEVTNEQYARFVQETGHPPPPNWKGEKTFPPGTAKLPVAEVSWDDAQAFAKWAGKRLPTEVEWEYAARGTDRRLYPWGMEFDPTKLNAGRDISQIKDQRRQVGSFPGESPFGLLDMAGNVAEWTDSGYDLYPGSQAVIKPQFQPLKIIRGGCFADDARKTMVTRRLMNERTFRDLSTGFRCAKDAPPAKAAATP

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Crispr_ID: NC_016024_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016024_4

2481384-2481480

Orphan

Consensus_repeat	Method
ATTCAACCGTCGCTACGCGACGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_016024_4

>merge|NC_016024|4|2481384-2481480|CRISPRCasFinder
GTTCAGGCGTCGCTACGCGACGCGGGACGATTGGGGGGAACATCCTCCCCCGGCGTTGAAACGCCGGGCTAAATTCAACCGTCGCTACGCGACGGGC

>NC_016024|4|3|2481384-2481480|CRISPRCasFinder
GTTCAGGCGTCGCTACGCGACGCG	GGACGATTGGGGGGAACATCCTCCCCCGGCGTTGAAACGCCGGGCTAA
ATTCAACCGTCGCTACGCGACGGGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_016024.1\|WP_014100568.1\|2474028_2474505_+\|IS200/IS605-family-transposase	unknown	unknown	gnl\|CDD\|376616
NC_016024.1\|WP_014100575.1\|2489369_2490947_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274272
NC_016024.1\|WP_014100565.1\|2471266_2471512_+\|hypothetical-protein	unknown	unknown	unknown
NC_016024.1\|WP_014100577.1\|2491948_2492248_-\|hypothetical-protein	unknown	unknown	unknown
NC_016024.1\|WP_014100574.1\|2486407_2487880_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226957
NC_016024.1\|WP_014100564.1\|2469242_2471132_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|274350
NC_016024.1\|WP_014100561.1\|2465391_2466477_+\|UDP-3-O-(3-hydroxymyristoyl)glucosamine-N-acyltransferase	unknown	unknown	gnl\|CDD\|234858
NC_016024.1\|WP_014100578.1\|2492529_2492760_+\|AtpZ/AtpI-family-protein	unknown	unknown	gnl\|CDD\|378198
NC_016024.1\|WP_014100562.1\|2466480_2467068_+\|hypothetical-protein	unknown	unknown	unknown
NC_016024.1\|WP_014100560.1\|2464783_2465395_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|369777
NC_016024.1\|WP_014100573.1\|2485726_2486398_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NC_016024.1\|WP_014100563.1\|2468216_2469230_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293817
NC_016024.1\|WP_187288374.1\|2475384_2480349_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|271342
NC_016024.1\|WP_014100572.1\|2484173_2485541_-\|GTP-binding-protein	unknown	unknown	gnl\|CDD\|349766
NC_016024.1\|WP_014100566.1\|2471488_2473054_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293836
NC_016024.1\|WP_014100571.1\|2483054_2484128_-\|WD40-repeat-containing-protein	unknown	unknown	gnl\|CDD\|238121
NC_016024.1\|WP_014100579.1\|2492769_2494122_-\|FAD-dependent-monooxygenase	unknown	unknown	gnl\|CDD\|223727
NC_016024.1\|WP_041569203.1\|2473052_2474039_+\|TonB-family-protein	unknown	unknown	gnl\|CDD\|367555
NC_016024.1\|WP_014100576.1\|2490956_2491952_-\|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	unknown	unknown	gnl\|CDD\|234626
NC_016024.1\|WP_014100580.1\|2494244_2496284_+\|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme	unknown	unknown	gnl\|CDD\|270916

Protein	Function_ID	Function_description	E-value
NC_016024.1\|WP_014100568.1\|2474028_2474505_+\|IS200/IS605-family-transposase	gnl\|CDD\|376616	pfam01797, Y1_Tnp, Transposase IS200 like. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.	3.57995e-37
NC_016024.1\|WP_014100575.1\|2489369_2490947_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|274272	TIGR02733, similar_to_to_phytoene_dehydrogenase, C-3',4' desaturase CrtD. Members of this family are slr1293, a carotenoid biosynthesis protein which was shown to be the C-3',4' desaturase (CrtD) of myxoxanthophyll biosynthesis in Synechocystis sp. strain PCC 6803, and close homologs (presumed to be functionally equivalent) from other cyanobacteria, where myxoxanthophyll biosynthesis is either known or expected. This enzyme can act on neurosporene and so presumably catalyzes the first step that is committed to myxoxanthophyll. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	3.89154e-104
NC_016024.1\|WP_014100580.1\|2494244_2496284_+\|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	6.99161e-109
NC_016024.1\|WP_014100574.1\|2486407_2487880_+\|ABC-transporter-permease	gnl\|CDD\|226957	COG4591, LolE, ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane].	4.13764e-11
NC_016024.1\|WP_014100564.1\|2469242_2471132_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	5.02474e-20
NC_016024.1\|WP_014100561.1\|2465391_2466477_+\|UDP-3-O-(3-hydroxymyristoyl)glucosamine-N-acyltransferase	gnl\|CDD\|234858	PRK00892, lpxD, UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional.	2.54847e-152
NC_016024.1\|WP_014100578.1\|2492529_2492760_+\|AtpZ/AtpI-family-protein	gnl\|CDD\|378198	pfam09527, ATPase_gene1, Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter. This model represents a protein found encoded in F1F0-ATPase operons in several genomes, including Methanosarcina barkeri (archaeal) and Chlorobium tepidum (bacterial). It is a small protein (about 100 amino acids) with long hydrophobic stretches and is presumed to be a subunit of the enzyme. It carries two transmembrane helices and is a magnesium or calcium uniporter. The atp operon of alkaliphilic Bacillus pseudofirmus OF4, as in most prokaryotes, contains the eight structural genes for the F-ATPase (ATP synthase), which are preceded by an atpI gene that encodes a membrane protein with 2 TMSs. A tenth gene, atpZ, has been found in this operon, which is upstream of and overlapping with atpI.	7.61103e-08
NC_016024.1\|WP_014100560.1\|2464783_2465395_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	5.76917e-13
NC_016024.1\|WP_014100573.1\|2485726_2486398_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	4.49812e-91
NC_016024.1\|WP_014100563.1\|2468216_2469230_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293817	cd07731, ComA-like_MBL-fold, Competence protein ComA, ComEC and related proteins; MBL-fold metallo hydrolase domain. This subgroup includes proteins required for natural transformation competence including Neisseria gonorrhoeae ComA, Pseudomonas stutzeri ComA, Bacillus subtilis ComEC (also known as ComE operon protein 3) and Haemophilus influenza ORF2 encoded by the rec-2 gene, as well as Escherichia coli YcaI which does not mediate spontaneous plasmid transformation on nutrient-containing agar plates. It also includes the phosphorylcholine esterase (Pce) domain of choline-binding protein e from streptococcus pneumonia. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. .	1.44652e-77
NC_016024.1\|WP_187288374.1\|2475384_2480349_-\|hypothetical-protein	gnl\|CDD\|271342	cd14948, BACON, Bacteroidetes-Associated Carbohydrate-binding (putative) Often N-terminal (BACON) domain. The BACON domain is found in diverse domain architectures and accociated with a wide variety of domains, including carbohydrate-active enzymes and proteases. It was named for its suggested function of carbohydrate binding; the latter was inferred from domain architectures, sequence conservation, and phyletic distribution. However, recent experimental data suggest that its primary function in Bacteroides ovatus endo-xyloglucanase BoGH5A is to distance the catalytic module from the cell surface and confer additional mobility to the catalytic domain for attack of the polysaccharide. No evidence for a direct role in carbohydrate binding could be found in that case. The large majority of BACON domains are found in Bacteroidetes.	5.99332e-16
NC_016024.1\|WP_014100572.1\|2484173_2485541_-\|GTP-binding-protein	gnl\|CDD\|349766	cd03112, CobW-like, cobalamin synthesis protein CobW. The function of this protein family is unknown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterize it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage caused by mitomycin. YijA gene is a homologue of the CobW gene which encodes the cobalamin synthesis protein/P47K.	1.15025e-102
NC_016024.1\|WP_014100566.1\|2471488_2473054_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293836	cd16278, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily.Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	7.34585e-44
NC_016024.1\|WP_014100571.1\|2483054_2484128_-\|WD40-repeat-containing-protein	gnl\|CDD\|238121	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.	3.49435e-33
NC_016024.1\|WP_014100579.1\|2492769_2494122_-\|FAD-dependent-monooxygenase	gnl\|CDD\|223727	COG0654, UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion].	5.66226e-47
NC_016024.1\|WP_041569203.1\|2473052_2474039_+\|TonB-family-protein	gnl\|CDD\|367555	pfam03544, TonB_C, Gram-negative bacterial TonB protein C-terminal. The TonB_C domain is the well-characterized C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance.	4.89121e-11
NC_016024.1\|WP_014100576.1\|2490956_2491952_-\|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	gnl\|CDD\|234626	PRK00091, miaA, tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed.	7.49182e-130

>NC_016024.1|WP_187288374.1|2475384_2480349_-|hypothetical-protein
MSGLGAGPGSADRSFGYASGGTGAFQMTDLLNRIGVNIPEPGEIRAIAVQRVGANANKFIVGGNFVYRVPGTNQVYRNLMRLNPNGTVDISFVPGLLIPVVNALVVQSTPLLADRIVVGCETAPQLFRLLPNGAQDTTFSPPPLTPPTVAVLALEVEPLLLPPSVPNPTADYIYVGLNGGTIGGRTNLARLLPNGGPDSTPGTFWGPQTAPAVQVSVNGPVRAIKFADRLGGLGLPGIVVGGAFNLAQGGPFPPPPSFECLNVAFFPTDGDFFSFSVGFFTNFFKGFDGPINAIAVSVSPANVSEIFVGGEFGNCVTFASPPNVARPRVAKFSFFAGLDTVFNPNPATSVPNPVRALVLTGGPPNFTAPPPSPPLPPPPPLLLSVLHVGGQETTTAFADVALSPVTGGLVVDVDPITPGLQPTFFTRSPFFPANPAVVRAMAANNQPLPNGGALFGGAFLNATVYGQNLNAPAQKLVATFTNLYSPPSPLGPVFSLPPPPPPFGPNPGTLPGFVALGPTQFYASALLPNGDLLIGGDVGVNGNASLPASLDDLEAVLYRIDPCGTVNVVARFRNISGYLVRNDVDNGTFVSPPQDINITPGQGFRRVDFVDPPSIRAIAVDSAGNIYVGGQFNRVSDGPGGPFQPWNNLIRLKSDGTIDPLFAPGAGLTSYAPGYPVMRLGGPTGFGTAGVGFTTVDPQTALPALTGNCDATPTPPVTGTGEKFNPNEGRVNAIVLQPNGRILIGGEFKCYNGIPRGGLARLLPNGSLDTSFGDPLAPLPGVDDYSLCDDPIPPPGVPRTNPAVAYNRARVNAILLQPDGSVVVGGLFGKANGIARYNLARFDSAGFLDLTFSSGPTSTVFPTGTAGVGGGGSGATSNGRGGEIFALARQSLGPNAGRILVGGVFTTILNQTGAPGNLPRTAFTRFETNGRHDATFAQLNFTAAGTVRAIALQADDRPIIGGSFRIGPGTAGGTQYTSNTTRVRVFRCGVNGAFTDTVDSLNIPRSSWLAVQPPPGVTVPFQPGPYAVPGVGSLASVFAPTATLPEINYYPGGSVSPAFGTGFFNATNVAMAVNTIALDPTRRRAYIGGLFNVFESARADFQNDNAGAPNGLSLDIRWPGVAALQTGCTYGLVAPTFPPFTVLPAGGTVNLGAINPAGGNLTIGSLTRSAVSVCDALPTVSTGSTFVTIVGVVPRTAGPGPSFADIIINVSPNNTGANRTGSVTVTLPSETSTSPPPTTFTFTQGPASGCTYTATAVPASFPVAGGTGQFQITTGAGCTWTITGLPTWISASPLSGSGSSTVNFTVAANTGAPRSATVTVAGQNITITQAGTCTLTLGTATGTSLPVTGGTGSFTVTTLAGCTYTATSSAPWLVITGGASGGPTGTVTFSVGRNSGAARSATITVTAPGVPAQTVTVSQAPDLAGPDTVGMFRSSNGFFYLRFSNTSGNADTDFFYGTAGDVPLSGDWDADGVTTIGIFRNGQFFLRNSNTAGFADVPAFAISGTQPGDIPLAGDWDGNGSTTVGLFRAGVFLLRNSNTAGPADVVINYALPTDTPIVGDWDGDGVTTIGLFRASVAFFGLRNSNTAGPADLQFFFGAPNDVPVAGDWDNDGVTTIGVFRAGTFFLRNSNTAGVANLTVNYGLATDRPVIGRWQ
>NC_016024.1|WP_014100568.1|2474028_2474505_+|IS200/IS605-family-transposase
MTGSVEGVTANTYSSLFYHVVFSTKQRTKFIRPEIEQRVWAYLGGVASRQGAKAVQIGGVEDHVHVLLMAPPTVSPAELVSRIKGDSSRWIHEVFPELRNFGWQDGYGVFSVSRSNVPQVVKYIQNQREHHRVRTFQEEYLLFLKKHQVAYDERYLWG
>NC_016024.1|WP_041569203.1|2473052_2474039_+|TonB-family-protein
MVNQRAPVWPQRSQYTLGAHHVTYCWLWLLLVGLWGGCLWALPAGARPLPAGLFVSDEPLTVAVLPPDIADDVGGVTSEGLLAALEQALAREGLEVVPRAQVFAAVPAGRPLDFNPTCTAAQALGARVGSEGYVLVRLRRGERSLSDRQTIVGGTLHLFAVETRTGQLVASEHVDFIEGKEGFLPAVAAGIEAAAQRFASDWRRVRGQTPGMGCAAGGDGADEVLDLRDGVLPPGVTAPVPLVRARPEPTGLARAAGVTATVMVEVCVGRDGQVREVAVVRWAGYGLEAAVEKALRAVRFRPALRQGKPVAAWFVAAFNFRSSPADDR
>NC_016024.1|WP_014100566.1|2471488_2473054_-|MBL-fold-metallo-hydrolase
MTSVVPKYASAVILLRRNETGDWRFFWARRAQAAPFLGGYHAFLGGRRDPEDEQVPVRHATDPEHAAQCACAVREVFEEAGILLAESRLTAPETRLAVRADLMAGRLTFAEVCARFAVEIDARRLIPGGRWVTPVGVPRRYDTTFFVSRLDGADEPELWPDEMVDGQWVTPAEAMAAWAQGAVRLVPPTLHSVRSLLRWTTEGFAGREDFQRLRELLHDHPAAHGEPPAFIELAPGIVTFPVRTPTLPPATHTNCYLVGDRELVVIDPASPYPEEQARLDAHLTWLAEQCGARVTAIWLTHHHPDHVGGAAHLSRRWNVPVAAHPITARLLEGKVQVSQWLADGDGQFIPASPAMGRWSTTPPGWPGWRLRAVFTPGHAPGHLCFFEETTGTLLSGDMVVGLGSVLIDPDEGDMAAYLASLRRLQTLPVQLIAGGHGPALGEPQAVLAAYLAHRQQREESILAALRSGATTVADLVAVVYADTPAALHPLAARSVQAHLVKLTREGKVQQSGGRLQLADVA
>NC_016024.1|WP_014100565.1|2471266_2471512_+|hypothetical-protein
MKPVICTFCNSEIYTYVGPEPVELKAVHFKPTRPGWGAPKPGDPLYCPVCGSRFVGVSVQNKQLRMVVSSEYAGSGNVGKL
>NC_016024.1|WP_014100564.1|2469242_2471132_-|tetratricopeptide-repeat-protein
MVNIQKFAAHRHWPWLLAVGLAGLVYANTLGNGFTYDDTPIIVNNPTIRSLADVPRLFLTGYWEHRQSGGNNYRPMLATTLAVDYALWGLHPVGYHLTNLLLHAANTAWVWWLLRCYRAAPWLALLAALVFAVHPVHTEAVANVVGRAELLGMCFGGLMWWSWVQARRNAEHAGRWRALAAAAYLAAMLSKENMVVLPAALWLAEVLRVRRHLWRAGWSAWWITTRPFFWLAIPWLPYAGLRLVSQQGFQPTGALSGNPMYAQTLWERLVTMAGVSLEWYRLVFLGFPLKPWYDAHNLALTPVWSWRTGLGGLVTLGLVVGAVAAVRRFPLLTFAVGFWFITLALVSNIIAPLWTPLGERWLYVPSVAYAIAVAWVLVRLGGMTSQQPAAAWRVGVSVGMALVLFIGYAYGTSRRNLDWQSDWRLFTRFLETDPQHPLPYTSLAHAWQTTDPAQARAYYEQALARVPNFFLALLGLAQLDLREGRIEAAHARLGQMVAAKPPEVVPTDADWGLVHALYARTLALQGDTAHALEQIAEARRYGPRDTPTLTSCAIAYVNLGQIAEAEAILREALDLGVDTPTIRFNLGSVLLRQGRTDEAERHFEAALRLDPDFAPARLARDKLQPAGTP
>NC_016024.1|WP_014100563.1|2468216_2469230_+|MBL-fold-metallo-hydrolase
MRKDRRSSSARRGWQGCLLVVGLLGLAAASLWLLWHFRDRLIPGPPPLAGKLLHIHAIDVGQGDSYLIVTPEKKTILIDAGPAEAGSKVVAFLRQQGIAELDLVIATHPHADHIGGMGYVLESFKVKNFLDSGQEHTTLTYRRMLEAVKKHVGRLTLAQAGQKFNLDNGITLSVLGPRQPWLQNVSGSDLNANSVVVRLDYGQFSMLLTGDAEDETEDRLLTDGAPLQVTVLKVAHHGSRHSTRERFLRAATPSVAIISCGATNRYGHPAQATLDRLRRLDVALYRTDLHGDITLTTNGQEYRITPTRQVAASELWRGRQPDTANDSGDEMPRRRAG
>NC_016024.1|WP_014100562.1|2466480_2467068_+|hypothetical-protein
MMTVHRFCFQRYGIALLAALVLLAMTLPGRAAAPVAFTSAYTDLNLRCRYDNTGASEGSDAPMYCTGYGNYRLLVSFSAFAADIFVEARNRSFSRLLAEGQAPGYTREKGRKAEWRLADGKPFAVILRAFTYRTGPDDAPDFSRKVGERLVIKGLAGFEHIDFTVDTRATPNANLRARQLADDGYSAVGRAGVSW
>NC_016024.1|WP_014100561.1|2465391_2466477_+|UDP-3-O-(3-hydroxymyristoyl)glucosamine-N-acyltransferase
MNHLPSAPTLRDLAAAFGYTVEGTADAAEIVITGVAGLDEAGPTELTFLSNPRYAAKARTTRAAAIIVSQGVATEGLPCPVVRAPDAYLAFARMAGWFYRPPRPSPGIHPTAIIAPSARLGAEVSVGPYVVVGENVVLGDRVRLFAHTVIYDGARIGDDSVLHAHVVIREQVELGCRVTVHNHVTIGCDGFGYAKRPDGSWEKIPQAGRVIIEDDVEIGAGTQIDRPSVGETRIRRGAKLDNLVQIGHAVEVGEDTLLCAQVGIAGSATIGSRVILAGQVGVAGHLTIGDGVTALAQSGIPNDVPAGQQVAGYPAVDRRQWLRVSAAQARLPDLLKHVQHLEARLKALELAAREKDPSRKG
>NC_016024.1|WP_014100560.1|2464783_2465395_+|class-I-SAM-dependent-methyltransferase
MPDVLAQWMARLAGQRVLDIGCGRNKTPGALGMDANPHADADLVHNLDDVPYPFPEHAFDAVIGRHVIEHVQSPLAVIIELHRIVRPGGWVLLVAPHWTNPDFATDLTHRNHLNSYSFRNLTVGQEVFDFYAPVRFRQRPPYVTLLNLWRACGLEWLVNLDRRHPRWRFLRRFWEQYLNAVVRGKEVYFELEVVKPDGTPPAP
>NC_016024.1|WP_014100571.1|2483054_2484128_-|WD40-repeat-containing-protein
MRLPSIAAFLKGATRQLEVDWQAVLDDGVVALEWAPDGGHLAALSAAGTLTVWDGATGEQRWSCAAHRTGGMTLSWSADGTVLATGGQDRQVCLWEPTTGDRLVSLPAGAAWVERVAWSPPYQDGAPAVLASAAGKVLRFWTPTGDLISEHVRHTSTIADLHWHPQRRCLVTACYGLLTVWTPGADLPAEVFAWKGSHLAVRWQPQGRYLVVGDQDATVHVWDVTTGEDLVMSGYMIKVRELAWHPAGRFLATGGGAAVTLWDFAGDGPAGSTPIVLEGHSGLVTALAYCPDGGVLASGAEDGVLVWRPPEKPGRTVSPVGRYDVAGGVACLAWRSDGARLAAGGLQGEVLVVVVAA
>NC_016024.1|WP_014100572.1|2484173_2485541_-|GTP-binding-protein
MSSAGTQAAPQRVPVTVLTGFLGAGKTTLLNRLLSEQHGKRIAVIENEFGEIGVDHELVIEAEEEIFEMNNGCICCTVRGDLIRILGSLMKRRHKFDYILVETTGLADPGPVAQTFFVDEEIQRQTRLDGIVTLVDAKHVWEHFDTNEVQEQIAFADVILINKTDLVDAATLERLEQRIRAMNATANIRRTQHANAPVEALLDIGAFDLDRALAVDPQFLEPEYPFEYGGLYALTAGEATLELQPGPDPTLDLLFLPAPEGADDPLAALTDRAIVLFSEEPEPVTTGHRLTPEPRLRQLRLAADGPTRLTLDVPQTGHYVLLTQHHPEEFAAVLRQGGREVAPLHSRAYKPDHEHDAEVTSVGIKLPGDLDPKRLNAWIGELLQTQGPDIFRMKGILSLAGDPRRFVFQGVHMVFDGRPDRPWGAEPRHNALVFIGRHLDRAALEAGFRSCLVSS
>NC_016024.1|WP_014100573.1|2485726_2486398_+|ABC-transporter-ATP-binding-protein
MSLLQIRQLRVQYPGPDGEPPTPVLDIPDWGVAAGEQVALVGASGSGKTTLLHVVAGIVLPDSGEVRLGDTDITRLDEASRDRFRAANIGYIFQQVHLLPAFTALENVLLGMTFADNRAGTAEALALLESVGLRERARYFPRQLSAGQQQRVGIARALANRPRLVLADEPTSALDARHRDAVIDLMQRLCQDIGAALVVVTHDEAVARRFPTTIRLADINHVK
>NC_016024.1|WP_014100574.1|2486407_2487880_+|ABC-transporter-permease
MHTLTVIYRNLRQRWLSTGLTALSIGLGVALVTAITALRQQAQANFDNVAASYELVVGAKGSPLQLVLNTVFHLDVPVGNLPYSYYRKLKADDRVAYAIPLALGDNYRGFRLVGTEPEYFNLVRLKDGQPVAVAQGRPFAADYEAVIGSVVVRETGLGLGQTFVARHGVEDTAAAEEHEDAPFTVVGILRETGTPLDRVIFISLGSVDEIHQESRDKGGKSLLEQLEALPAEPSGSPPEDRPEDRNDHDHHHHHRKKPAAPPVGDTPGGDKPAVLPGQTTSAPAAPNQAAVGVPGQAIDEVTAIIVKLRSPGYLFLMHREINKGKDAQAALPGVEVQKLFTIVGTVDRALLLMSVLVVVVAAVSVLVAIYNSLAERRREVAVLRALGAHRRTVFGWLVWEAAMTAALGGVVGVLLGHALLAVAGSSLKFLSGLPLDPWRWTRLEVGPAWLTAYVPFEVAVIAGTLVLGAVMGLLPAALAYRTNVARHLSE
>NC_016024.1|WP_014100575.1|2489369_2490947_-|FAD-dependent-oxidoreductase
MRPLAETTFDVVVIGAGVAGLTAALLLQHDGYRTLLLEAHDKAGGCAGYFFHKGYNFDVGATVLMGLDPAGLHTQVFNRLGWPLPESTLIKQVDVHLPDRCVHIAHNPEIWAHERVVRFARTPEEAERLRAFWQLVDRTADTLWTATAKLPVLPLRHWRDVVANLRLVSPDFLRAAPYLFSTVEDVLRRYRLADHAPLRAFLDGLLLITVQETAARAPFLNGAAGLDIYRHGIRRARGGMKSFIKAHVAAFRELGGVLRLRQRVTRITPAAGGGYTVETDRGLTVHAPRVVANLPIWNVPSLVAADVSRQMKRPLNKAGVGWGAFTLYLGVRAEVIPDDTPLNHQVLLEYGAPLDDGNSAFLSLSEVDDRASAPPGRRTLNLSTHTEVSPWWELSPEDYAARRAAVVERLLTAAERVFPNLREGIECALPGTPRTFARYTGRAQGMVGGLRTTLWNSNLFGIGSRDVGLPDFWLVGDTVFPGQGTPACALSGINAWRDIGMRVSRPQAWERGRPARMKQIAFNRY
>NC_016024.1|WP_014100576.1|2490956_2491952_-|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA
MTPRPIPVIVGPTCSGKSDLGLAVARALDGEIINLDSIQVYRGLDVATAKVPPALRALVPHHLIDVADPAEHYTAGRYAREATACLADIEARGRTAVFVGGTGLYFDALRGRLFAEDNPTDLRLRARLHAIRARRGAPWLHRMLRRLDPATAARLQPNDWSRTMRALEFFLCTRTPLSQRQRQLAPPPPFVARMRLLVLSPPRAELYARINARVEAMVAAGLLDEIRRLLAAGVPPDAEAFQAHGYRRFIEYLRGERTYASAVEQMKTDTRHYAKRQLSWWRREPEAHWLAGFGSDPEVQRQALELLRAPAPVRPGTQLAGELPTSASPSL
>NC_016024.1|WP_014100577.1|2491948_2492248_-|hypothetical-protein
MAQRQHFEYQIGDEVSFAAGHGMQYGEVVRIITPGPDGAIEIQWEDGRREVKKTRDRAIHLVRRASGISEVDERRGQRRRSTDDEIAEVRRSDIRRRHG
>NC_016024.1|WP_014100578.1|2492529_2492760_+|AtpZ/AtpI-family-protein
MPSPQNSDNDEAAQRARMLTAAGLALGLPMTILGSFLVGYWLDRQLQTAPLWFFLLGIAGLVSSARLLYRLWEQLR
>NC_016024.1|WP_014100579.1|2492769_2494122_-|FAD-dependent-monooxygenase
MSDELMVAPSFTVCGAGLAGTLAALYLARQGNRVTLYERLPDMRTHSVPRGRSINLALSRRGLHALEALGLAPVIHPLTIPMRGRMIHSLQGELTFQPYGRTPEETIFSISRHQLNCALLDAAAHWPNLEIHFQSRCVGLNLSSMTLEIEDTRTRTVRQVSARTVVGADGAFSAIRQALQRTDRYDYAQTFLPHGYKELTIPALPGGQHALEKNYLHIWPRQDFMLIALPNLDGSFTCTLFLAYEGAESFASLTDEDAIRRFFDRHFPDVTPLMPTLVEDFQHNPTGSMVTIRCFPWQYAGRVVLIGDAAHAVVPFYGQGMNASFEDCFVLDECLRRHNGDTSAAFLDYQQQRKVNTDALAELAYENYLEMRAKVASPWFLMRRRLEYALSNLLGDRFLPLYTMVSFTRIPYAEARARAARQDRWLDAALATLALLVLLALLWWLWPAGR
>NC_016024.1|WP_014100580.1|2494244_2496284_+|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme
MKQCPACGQQYEDNVTFCPVDGKGLIPLLIDGKYRIEKKIGEGGMGQVYRAIHVEIGTPFAVKVLHAQFGEDEKAVARFRREAQAAAQIRHPNAVSVTDFGVTKDSNLVYFVMEYLEGESLGERLRETHALPMEDIHFIYSCVCSALHAAHLKGIVHRDVKPDNIFLLLDEERNIKDVKVLDFGIAKLKRQDKNTLTASGTVIGTPDYMSPEQCQGLELDARSDIYSLGVILYELFTGRVPFQSESAMTTLMAHVSQPPPPPVTINPAVPPGINRLILRTLAKQPHERPETALHLLGELEQALQEAGVQLGTASMTNLLKTQRHVGRSTVGGSKAPTTDVTEGTPTTNRTLALSGANIAVERATVESQRATGLNRKSTSEPGGETKTYVAVDGKRAVGARLWLPFAAVVGLVVVGLIAGGGWYLSRRAATAGQGATNLDSPKPPPAPPGMVYIPGGTFIMGNNASADDFEKPEHERQVAPFFMDRTEVTNEQYARFVQETGHPPPPNWKGEKTFPPGTAKLPVAEVSWDDAQAFAKWAGKRLPTEVEWEYAARGTDRRLYPWGMEFDPTKLNAGRDISQIKDQRRQVGSFPGESPFGLLDMAGNVAEWTDSGYDLYPGSQAVIKPQFQPLKIIRGGCFADDARKTMVTRRLMNERTFRDLSTGFRCAKDAPPAKAAATP

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_016024_3	3.1\|598066\|55\|NC_016024\|CRISPRCasFinder	598066-598120	55	NC_016024.1	598171-598225	1	0.982
NC_016024_5	5.1\|2481656\|41\|NC_016024\|CRISPRCasFinder	2481656-2481696	41	NC_016024.1	2475196-2475236	2	0.951

1. spacer 3.1|598066|55|NC_016024|CRISPRCasFinder matches to position: 598171-598225, mismatch: 1, identity: 0.982

ctgacggaagttgcggctgtaaaggccgcgcagcagacgttgatgacggaagtcc	CRISPR spacer
ctgatggaagttgcggctgtaaaggccgcgcagcagacgttgatgacggaagtcc	Protospacer
****.**************************************************

2. spacer 5.1|2481656|41|NC_016024|CRISPRCasFinder matches to position: 2475196-2475236, mismatch: 2, identity: 0.951

gggattccaacccggcggtgtggtgggttggtcacgtgatg	CRISPR spacer
gggattccaacccggcgatgtggtgggtttgtcacgtgatg	Protospacer
*****************.*********** ***********

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

2425019 : 2433359

uncultured_Mediterranean_phage(16.67%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014100523.1\|2425019_2426198_-	trypsin-like peptidase domain-containing protein	A0A1B1IT49	uncultured_Mediterranean_phage	2.1e-31	32.8
WP_014100524.1\|2426221_2427049_-	NAD(P)-dependent oxidoreductase	Q06VL0	Trichoplusia_ni_ascovirus	1.3e-06	28.0
WP_014100526.1\|2427468_2428824_+	DUF92 domain-containing protein	NA	NA	NA	NA
WP_014100527.1\|2428882_2430796_+	SUMF1/EgtB/PvdO family nonheme iron enzyme	A0A1V0SBL0	Catovirus	1.4e-13	25.1
WP_081464839.1\|2430823_2431684_+	formylglycine-generating enzyme family protein	A0A7F1	Microcystis_virus	9.9e-23	39.1
WP_148264023.1\|2431721_2432615_-	thymidylate kinase	A0A191SAS6	Nostoc_phage	5.2e-06	22.4
WP_041569875.1\|2432663_2433359_-	thymidylate kinase	Q2Z0N0	Pseudomonas_phage	1.5e-05	26.4

DBSCAN-SWA_2

2639841 : 2648664

Erysipelothrix_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014100705.1\|2639841_2641251_-	dihydrolipoyl dehydrogenase	A0A2K5B2C5	Erysipelothrix_phage	9.2e-42	29.9
WP_041569931.1\|2641716_2642733_+	GDP-mannose 4,6-dehydratase	M1IBC3	Acanthocystis_turfacea_Chlorella_virus	2.6e-110	59.9
WP_014100707.1\|2642749_2643682_+	GDP-L-fucose synthase	M1HKX0	Paramecium_bursaria_Chlorella_virus	1.5e-104	60.3
WP_187288382.1\|2643752_2644424_+	16S rRNA (guanine(527)-N(7))-methyltransferase RsmG	NA	NA	NA	NA
WP_014100709.1\|2644588_2645392_+	ParA family protein	Q8JL10	Natrialba_phage	7.1e-23	30.1
WP_014100710.1\|2645342_2646203_+	ParB/RepB/Spo0J family partition protein	I3NLC2	Bifidobacterium_phage	6.7e-19	35.0
WP_014100711.1\|2646363_2648664_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	1.4e-156	40.3

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_016025

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NC_016024

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection