CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_021172	Hyphomicrobium denitrificans 1NES1, complete sequence	1 crisprs	csa3,cas3,RT,WYL,DEDDh	0	1	2	0

1. NC_021172

CRISPR-Cas detection and classification

Crispr_ID: NC_021172_1

• CRISPR_ID: NC_021172_1
• CRISPR_location: 2605605-2605723
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NC_021172_1

Consensus_repeat	Method
TTTTTCTTGGCTTCTTCTTCGGC	CRISPRCasFinder

spacers of NC_021172_1

>1.1|2605628|25|NC_021172|CRISPRCasFinder
CTTTTTTTTCAGCTCAGCGGCGCGC
>1.2|2605676|25|NC_021172|CRISPRCasFinder
TTTTTTCTTGGCTTCTTCTTCGGCT

CRISPR arrays and Neighbor proteins around NC_021172_1

CRISPR arrays

The CRISPR arrays of NC_021172_1

>merge|NC_021172|1|2605605-2605723|CRISPRCasFinder
TTTTTCCTGGCTTCTTCCTGCTTCTTTTTTTTCAGCTCAGCGGCGCGCTTCTTTTTCGCGGCCTCCTCGGCTTTTTTCTTGGCTTCTTCTTCGGCTTTTTTCTTTGCCTCGTCCTCAGC

>NC_021172|1|1|2605605-2605723|CRISPRCasFinder
TTTTTCCTGGCTTCTTCCTGCTT	CTTTTTTTTCAGCTCAGCGGCGCGC
TTCTTTTTCGCGGCCTCCTCGGC	TTTTTTCTTGGCTTCTTCTTCGGCT
TTTTTCTTTGCCTCGTCCTCAGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_021172.1|WP_041320464.1|2608072_2608375_+|hypothetical-protein	unknown	unknown	gnl|CDD|340946
NC_021172.1|WP_015598822.1|2593672_2594125_+|hypothetical-protein	unknown	unknown	unknown
NC_021172.1|WP_015598826.1|2598680_2600015_-|tRNA-lysidine(34)-synthetase-TilS	unknown	unknown	gnl|CDD|238950
NC_021172.1|WP_015598839.1|2608782_2608968_+|hypothetical-protein	unknown	unknown	unknown
NC_021172.1|WP_015598827.1|2600042_2601068_-|tol-pal-system-protein-YbgF	unknown	unknown	gnl|CDD|188247
NC_021172.1|WP_015598840.1|2608964_2610350_+|APC-family-permease	unknown	unknown	gnl|CDD|129986
NC_021172.1|WP_041320466.1|2608386_2608773_+|hypothetical-protein	unknown	unknown	unknown
NC_021172.1|WP_015598828.1|2601242_2602031_-|OmpA-family-protein	unknown	unknown	gnl|CDD|143586
NC_021172.1|WP_015598843.1|2611412_2611889_-|tol-pal-system-associated-acyl-CoA-thioesterase	unknown	unknown	gnl|CDD|274304
NC_021172.1|WP_015598835.1|2606707_2607424_-|protein-TolQ	unknown	unknown	gnl|CDD|131843
NC_021172.1|WP_015598834.1|2606244_2606703_-|biopolymer-transporter-ExbD	unknown	unknown	gnl|CDD|223917
NC_021172.1|WP_015598829.1|2602175_2602691_-|peptidoglycan-associated-lipoprotein-Pal	unknown	unknown	gnl|CDD|274307
NC_021172.1|WP_015598844.1|2611885_2612824_-|metallophosphoesterase	unknown	unknown	gnl|CDD|224326
NC_021172.1|WP_015598825.1|2596568_2598524_-|ATP-dependent-zinc-metalloprotease-FtsH	unknown	unknown	gnl|CDD|273520
NC_021172.1|WP_015598832.1|2603684_2605022_-|Tol-Pal-system-protein-TolB	unknown	unknown	gnl|CDD|235351
NC_021172.1|WP_015598842.1|2611093_2611381_+|hypothetical-protein	unknown	unknown	unknown
NC_021172.1|WP_015598823.1|2594339_2595041_+|sulfotransferase-family-2-domain-containing-protein	unknown	unknown	unknown
NC_021172.1|WP_041321265.1|2610416_2611097_+|hypothetical-protein	unknown	unknown	gnl|CDD|377944
NC_021172.1|WP_015598824.1|2595158_2596265_-|dihydropteroate-synthase	unknown	unknown	gnl|CDD|238380
NC_021172.1|WP_015598821.1|2592735_2593644_+|ParA-family-protein	unknown	unknown	gnl|CDD|224113

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_021172.1|WP_041320464.1|2608072_2608375_+|hypothetical-protein	gnl|CDD|340946	cd17388, MFS_TetA, Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters. This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	0.00223142
NC_021172.1|WP_015598844.1|2611885_2612824_-|metallophosphoesterase	gnl|CDD|224326	COG1408, COG1408, Predicted phosphohydrolases [General function prediction only].	2.53219e-62
NC_021172.1|WP_015598826.1|2598680_2600015_-|tRNA-lysidine(34)-synthetase-TilS	gnl|CDD|238950	cd01992, PP-ATPase, N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This domain has a strongly conserved motif SGGXD at the N terminus.	8.08516e-68
NC_021172.1|WP_015598827.1|2600042_2601068_-|tol-pal-system-protein-YbgF	gnl|CDD|188247	TIGR02795, Uncharacterized_protein_in_oprL_3'region, tol-pal system protein YbgF. Members of this protein family are the product of one of seven genes regularly clustered in operons to encode the proteins of the tol-pal system, which is critical for maintaining the integrity of the bacterial outer membrane. The gene for this periplasmic protein has been designated orf2 and ybgF. All members of the seed alignment were from unique tol-pal gene regions from completed bacterial genomes. The architecture of this protein is a signal sequence, a low-complexity region usually rich in Asn and Gln, a well-conserved region with tandem repeats that resemble the tetratricopeptide (TPR) repeat, involved in protein-protein interaction.	5.04574e-37
NC_021172.1|WP_015598840.1|2608964_2610350_+|APC-family-permease	gnl|CDD|129986	TIGR00908, putative_ethanolamine_permease, ethanolamine permease. The three genes used as the seed for this model (from Burkholderia pseudomallei, Pseudomonas aeruginosa and Clostridium acetobutylicum are all adjacent to genes for the catabolism of ethanolamine. Most if not all of the hits to this model have a similar arrangement of genes. This group is a member of the Amino Acid-Polyamine-Organocation (APC) Superfamily. [Transport and binding proteins, Amino acids, peptides and amines].	3.19296e-41
NC_021172.1|WP_015598828.1|2601242_2602031_-|OmpA-family-protein	gnl|CDD|143586	cd07185, OmpA_C-like, Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA. OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.	4.89177e-18
NC_021172.1|WP_015598843.1|2611412_2611889_-|tol-pal-system-associated-acyl-CoA-thioesterase	gnl|CDD|274304	TIGR02799, Acyl-CoA_thioesterase_YbgC, tol-pal system-associated acyl-CoA thioesterase. The tol-pal system consists of five critical genes. Inner membrane proteins TolQ and TolR convert protomotive force to energy that is transduced through TolA to an outer membrane complex of TolB and Pal. The system is known to be required to maintain outer membrane integrity. In a system with several homologous parts, ExbB and ExbD transduces energy through TonB to a variety of outer membrane proteins, many of which are siderophore receptors. The tol-pal system therefore may also be involved in transport. This family consists of a protein nearly always found in operons with the genes of the tol-pal system. The significance of this thioesterase to the tol-pal system is unclear, but either of two observations may be relevant. First, Pal, or peptidoglycan-associated lipoprotein, has a conserved N-terminal cleavage and acylation that makes it a lipoprotein. Second, the tol-pal system is implicated not only in the import of certain organics but also in the maintenance of outer membrane integrity (by an unknown mechanism).	1.7593e-46
NC_021172.1|WP_015598835.1|2606707_2607424_-|protein-TolQ	gnl|CDD|131843	TIGR02796, Protein_TolQ, TolQ protein. TolQ is one of the essential components of the Tol-Pal system. Together with TolR, it harnesses protonmotive force to energize TolA, which spans the periplasm to reach the complex of TolB and Pal at the outer member. The tol-pal system proves to be important for maintaining outer membrane integrity. Gene pairs similar to the TolQ and TolR gene pair often number several per genome, but this model describes specificially TolQ per se, as found in tol-pal operons. A close homolog, excluded from this model, is ExbB of the ExbB/ExbD/TonB protein complex, which powers transport of siderophores and vitamin B12 across the bacterial outer membrane. The Tol-Pal system is exploited by colicin and filamentous phage DNA to enter the cell. It is also implicated in pathogenesis in several bacterial species [Transport and binding proteins, Other, Cellular processes, Pathogenesis].	5.08831e-103
NC_021172.1|WP_015598834.1|2606244_2606703_-|biopolymer-transporter-ExbD	gnl|CDD|223917	COG0848, ExbD, Biopolymer transport protein [Intracellular trafficking and secretion].	9.04059e-50
NC_021172.1|WP_015598829.1|2602175_2602691_-|peptidoglycan-associated-lipoprotein-Pal	gnl|CDD|274307	TIGR02802, Peptidoglycan-associated_lipoprotein, peptidoglycan-associated lipoprotein. Members of this protein are Pal (also called OprL), the Peptidoglycan-Associated Lipoprotein of the Tol-Pal system. The system appears to be involved both in the maintenance of outer membrane integrity and in the import of certain organic molecules as nutrients. Members of this family contain a hydrodrophobic lipoprotein signal sequence, a conserved N-terminal cleavage and modification site, a poorly conserved low-complexity region, together comprising about 65 amino acids, and a well-conserved C-terminal domain. The seed alignment for this model includes only the conserved C-terminal domain.	1.30887e-55
NC_021172.1|WP_015598825.1|2596568_2598524_-|ATP-dependent-zinc-metalloprotease-FtsH	gnl|CDD|273520	TIGR01241, ATP-dependent_zinc_metalloprotease_FtsH, ATP-dependent metalloprotease FtsH. HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides].	0
NC_021172.1|WP_015598832.1|2603684_2605022_-|Tol-Pal-system-protein-TolB	gnl|CDD|235351	PRK05137, tolB, Tol-Pal system protein TolB.	0
NC_021172.1|WP_041321265.1|2610416_2611097_+|hypothetical-protein	gnl|CDD|377944	pfam07934, OGG_N, 8-oxoguanine DNA glycosylase, N-terminal domain. The presence of 8-oxoguanine residues in DNA can give rise to G-C to T-A transversion mutations. This enzyme is found in archaeal, bacterial and eukaryotic species, and is specifically responsible for the process which leads to the removal of 8-oxoguanine residues. It has DNA glycosylase activity (EC:3.2.2.23) and DNA lyase activity (EC:4.2.99.18). The region featured in this family is the N-terminal domain, which is organized into a single copy of a TBP-like fold. The domain contributes residues to the 8-oxoguanine binding pocket.	0.00842828
NC_021172.1|WP_015598824.1|2595158_2596265_-|dihydropteroate-synthase	gnl|CDD|238380	cd00739, DHPS, DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and protein biosynthesis. Prokaryotes (and some lower eukaryotes) must synthesize folate de novo, while higher eukaryotes are able to utilize dietary folate and therefore lack DHPS. Sulfonamide drugs, which are substrate analogs of pABA, target DHPS.	2.5945e-120
NC_021172.1|WP_015598821.1|2592735_2593644_+|ParA-family-protein	gnl|CDD|224113	COG1192, Soj, ATPases involved in chromosome partitioning [Cell division and chromosome partitioning].	4.6888e-32

Protein sequences

>NC_021172.1|WP_015598832.1|2603684_2605022_-|Tol-Pal-system-protein-TolB
MSRKNPLQHALAFICLIAVGLTLDCGLATRALAQLKGTQTEGTIAPIPIAIPLFVGDDPQLAGNVSDVLQADLERSGLFRPLDRASFLEQIRDINAVPRFGDWRSVQADALVVGRVVNAGDGRVGAEFRLWDVASGKQLAGQRFSTSAQNWRRIAHMIADSVYERLTGEKGYFDTRIVFVDETGPAQNRVKRLAIMDQDGANVRLLTQGKELVLTPRFSPTNQEITYMSYTSDQPKVFIMNLETGRRELVGDFPGMTFAPRFSPDGQRVVMSLGTPDGRSSIYEMDLRTRQSRRLTESNGIDTSPSYSPDGRQIVFESDRDGAQRLYVMNADGSGAHPISQGGGSYSTPVWSPRGDYIAFTEQTGGQFLIGVMKPDGSGERVLTEGFHNEGPTWAPNGRVVMFWRDSQSTNGGPKIYSVDITGFNERQVTTPSFASDPAWSPLLN
>NC_021172.1|WP_015598829.1|2602175_2602691_-|peptidoglycan-associated-lipoprotein-Pal
MLASIARSMWLRLAAVSILAATVGACASNKELQPDALSGKYGAATPGSQRDFSQNVGDIVYFSTDSIDLTPEAQQTLTKQAQWLQQYSQYAITIEGHADERGTREYNIALGARRATTVRNFLSQHGVNGARIRTISYGKERPVAVCNDISCWSQNRRAQTVLNSGGVVSQR
>NC_021172.1|WP_015598828.1|2601242_2602031_-|OmpA-family-protein
MYKLRSSSVVIGVVSAVLAVMVALPLPTFAQNDDDGPNGETAAELLVDGLDAASDHAVDSARRLFQKLISVFPSSPEASRARRALSALDTNGGTEEDRAAIRADEAERTAEYRHAFLVSVGDRVFFAESSATLGGRACSIIENQARWLKVRPNLTVTVIGRSDDGGDRRSAQLLSTQRAEAVRDRLVAAGLDPSRIELRPTGNDDKVAVCSTSLCRAQNRNAEVFINDLRDQDPIRSSMQSPAARTTKSSLGRAVETGQVAQ
>NC_021172.1|WP_015598827.1|2600042_2601068_-|tol-pal-system-protein-YbgF
MAKRKRIPVGFGISAAAVALLLAATPVFAQSNEKAAKGSAAAATGESGLQARVRSLEEQLVDMQVVVGTLETLAKSGGSAPAPFPASTAGGDGDAARIEGLETQVRALTAQVQQLSDQVRSLGGTPRRSDIPASSDTALAGQEAHPQAQPPTAPNPGFGSTTVATGNDAIGGLLNSDGAHSPEAPPGAVGQTGAVPAPATVATAALAPASTSSNDPKQLYETAYGYLLQRDYGAAEAAFDEFLKKFPNDSLSGNAQYWLGETHFVRGQYKAAASAFLKGYQSYAQSAKAPDSLLKLAMSLDRLGQKDAACSSFAELASKFPTAPQSVKARAQSERQRVGCQ
>NC_021172.1|WP_015598826.1|2598680_2600015_-|tRNA-lysidine(34)-synthetase-TilS
MPRDAQVPVAPIEADAAFEQLAKFDHVVLAVSGGPDSMALLVLAAEWRQRRNGALPSLSAATVDHRLRPEASREAGFVARESLRLGLPHATLPWTDEKPLSGIPDAARQARYRLLEAHARSLAASTVAVVTAHHLDDQAETFAMRLARGAGVTGLSAMPAERALLEGSTVRLLRPLLPFPKSRLIATLEARGVPCVDDPTNKDSRYERARIRHALLPALVATGISAAALATSARRLGDAEAALHYAEERFTATLALSFGNEVFAAFDREAFREGPTLLRQRLLARLIARYGGASERPELSEIEDLAARLQAEEKSTATLGGAMVSSGSRFIRVWREAGRLAQPDLLLVPGESRTWDRRFIVRRVPEAIGPVRVRPLGQENYLVIAGRLIPGRRPPARAVHALPSFWKDDDLVAVPSLAPFAVASEAPFLEAGCELKALALSAAY
>NC_021172.1|WP_015598825.1|2596568_2598524_-|ATP-dependent-zinc-metalloprotease-FtsH
MNPNYQKLAIWAALFVLLLALYNLVSNPSQSRHTNEIQYSEFLDAVDKGTVSEAVIAGNRITGTRRDASGSEAAFSTYAPEDPNLVTRLRDKGVKFKARPAEDEVQSITSILLSWFPMLLLIGVWIFFMRQMQSGSGRAMGFGKSRAKLLTERHGRVTFEDVAGVDEAKADLEEIVEFLRDPQKFQRLGGRIPRGCLLVGPPGTGKTLIARAVAGEANVPFFTISGSDFVEMFVGVGASRVRDMFEQAKKNAPCIIFIDEIDAVGRHRGAGLGGGNDEREQTLNQLLVEMDGFEANEGIIIIAATNRPDVLDPALLRPGRFDRQIVVPNPDVIGREKILRVHMKKVPLAPDVDPKVIARGTPGFSGADLANLVNEAALLAARRNKRLVTQAEFEDSKDKVMMGAERKTMAMTEEEKLATAYHEAGHAIVNLVVPGNDPLHKVTIIPRGRALGVTMSLPERDRLSYSKQWCEGKIAMAFGGRVAEQIIYGREHLNTGASSDISQATGIAKRMVTEWGMSDKLGPLLYSENSQEVFLGHSITQQKNMSEETAKLIDEETRRIVTAGQNTAWEVLTKHKAELEAMAQALMEYETITGEECQAIMRGEKIARRDDDDGSKGPAGSAVPSAGRQPPRPRGESTGGIDIGPEPQPQG
>NC_021172.1|WP_015598824.1|2595158_2596265_-|dihydropteroate-synthase
MKRSIYLQPTAIFWDRTGRRRAVDEAEIPEWRGLPLAGGRLSFAALDVLTRASPETKRRTIVLGDAFSGDWGREALAAADILEELSSQRPRIAGLSLDRPRLMGIVNVTPDSFSDGGEHMSAEKAIAHGLELVAEGADILDIGGESTRPQSDLVPVEEELRRVIPVIEGLRAKTGAVISIDTRKAEVMRRAAAAGADILNDVSAFTHDRDSLAVAAEAGLPVIVMHAQGDPKTMNDNPQYDDVVLDVFDYLESRVQACVAAGIPKSKIVADPGVGFGKHLHHNVAVMAGLPLYHGLGVPILLGASRKKMIGQLCDVDDAKDRVPGSLACAVAGVAAGVQILRVHDVKETKQAIEVWRACAAGTEKGLA
>NC_021172.1|WP_015598823.1|2594339_2595041_+|sulfotransferase-family-2-domain-containing-protein
MIISFSRQFIFLKTQKTGSTSVEIALSALCSPDDVLTPIAPHEEQIRQQNGRAAQNFLIPRDFRPWWASASEILGLKRLSSGTSYYNHMSATELRARMDPALFDSFKKVTIVRNPWDREVSLFYWHTRASQAPQDFGKFVRRRLSNPERKTFKLYSIDGRIVATHILRYETLAKDYDRFVRSLGIADPVPLGNAKGAFRPNGARNYRDMYDDATREIVRQRYRREIDTFGYSF
>NC_021172.1|WP_015598822.1|2593672_2594125_+|hypothetical-protein
MSKGTQLWPGDKMRSFFSAHIRRETSLDDAAAERLAEALTKAVNRMLVWKMPDDVRHTDRVEAAPEIAARHARAENFNPYLFSAIVVLAKQGRDGLIKRLQEIKSAENLRAFAEAQHVPVDGKLRRLDDIRKAIVAAAEQRLADRKAAAS
>NC_021172.1|WP_015598821.1|2592735_2593644_+|ParA-family-protein
MAVFLAVANRKGGVGKSTVAVMLAHALAVHGGKRVLLIDLDSQCNASLILMGGQGWNEARKAGKTIADYFYDLFDGIPANARDYVSKNAGDVSAANGKPAPISLVPGSLLLEDIQGELYLKQANQSNVPDVVANRVRGRMESLIRRFEGDYDVVILDCAPGLSFAALAALKTADKVIVPFRPDYVSQLAVDRVAMLIEDTRNLDDLAEIPIEERRYACLANYVRNDDKDYMMIEEISLVHPVLETFLPQRNGIANAFDYVGQLRSIDTKYSDAAGDVKELYQEIARVIDSVAASKKTKVPVS
>NC_021172.1|WP_015598834.1|2606244_2606703_-|biopolymer-transporter-ExbD
MGASIKVGGGGGGRGRRRRGRNAPMSEINVTPMVDVMLVLLIIFMVAAPLLQVGIPVDLPEAKGQQIPTPKQEPLAVTVKVNGDVFIGDTQISLDDLATKLKAIAKNGYDETIFVRGDRGVPYGVVMKVMGRINDGGFKKLSFVLDQEKGGT
>NC_021172.1|WP_015598835.1|2606707_2607424_-|protein-TolQ
MNPADVAQGVVAPVNAAGFSFIELFMQASIVVKIVMTGLGLASVWSWAIIFEKLLAFRRARVESDRFEQLFWSGQSLDELYANLSRGRTITMAALFVAAMREWKRSVEGNIRALGGIQLRVEKVMDVTISREMERLDRRLLFLATVGSTAPFVGLFGTVWGIMTSFQSIAVSKNTSLAVVAPGIAEALFATALGLMAAIPAVVFYNKFSADSSAISQRLYAFSDEFAAIVSRQIDVRT
>NC_021172.1|WP_041320464.1|2608072_2608375_+|hypothetical-protein
MQKENPHADPRIAKLFSGDRNWSLVAVAVLWALYAFVFFETKDYLGDPQVGWTLAIFGGLVVLFNTAAILAMVAHLSEEREEIYGLDLHYIDLAKKKSYS
>NC_021172.1|WP_041320466.1|2608386_2608773_+|hypothetical-protein
MEKPHYEPPKQSALGQLFDSLFLLVLVLAALFTPLYLKLAGGGKIELPLADKSTWAGLGQNAAQAAQWEKLGFHPDTAAPLITSRFDYSFSPLELGITAVVVIGYFVLLFMFSKREYIEVIEERFGRK
>NC_021172.1|WP_015598839.1|2608782_2608968_+|hypothetical-protein
MDNWQLLEYAAWALSALLGLYMLFDTIKTNRAYSEDLLTSSREGEIDETLVIDPPHQGGHL
>NC_021172.1|WP_015598840.1|2608964_2610350_+|APC-family-permease
MNQATAVHGEKISLLRVLGPAHVWALGVGIVLVGEYMGWNFAVGKGGAIAALIACWAAGLLYTCVAMIDSEVTSTVAAAGGQYAQSKHIIGPLMAFNVGLYLVFAYTMLEAANAITLGYLVQTVGQMAGFAEAHDKPFIVLTIMFLAWLNYRGVYATLTVNLILTAIAFIAIVILFTAVKPWSTELLNHKEILNGLPYGWIGVLASLHFGLWYYLGIEGTCQAAEEVRSPARSLPLGTMTGIMTLLIAATMTWYLCAGLMPWEYLGQATTPLFDAARLTSSMPLMVLLFVGTMFSTLASANGCINDASRAWFSMGRDRYLPTWFGAVHPKNRTPFRSIVFLVPVALIFAYFAPLDQVITFSILSGLLEYTYMSIQVIFFRQMWPLDSIKRGYVHPFHPLPALVLLAICSTTYFAVFLGYGTQLIAMMVFFIVASLWFHFHRYKYVRRGDQFTMNWPRPRGY
>NC_021172.1|WP_041321265.1|2610416_2611097_+|hypothetical-protein
MPLMLAALLLVASVSILVFFGRHEARVAAAARHRILDPSLNVLEAAKVEIDACDFPKMEGKFRGRSFRVALVPDTLTFRRLPQLWLDVTLKRSLPVDGSVAILVRQSGADYFSLTDHLNERLAPPENFPDVCLIKGDGPGARHILDRIAPYVASLLRDPHFKEIAITPRGIRIMRQLAEGKRGDHLILRQIVFEGARLNPEELEDVIAAVLEIETLLLNVKLVSAA
>NC_021172.1|WP_015598842.1|2611093_2611381_+|hypothetical-protein
MNALQAERKPINPYLVLALAIVLPGMGHVAIGQQQRGFMFAMFTLLLALLTWQIAPPDRSMIGRSALGLFVWALSIPDAYRLARVNWETWKRKHP
>NC_021172.1|WP_015598843.1|2611412_2611889_-|tol-pal-system-associated-acyl-CoA-thioesterase
MTAREWPDLAGRLIRDDSGQRHVLAVRVYFEDTDAGGVVYHASYVRFCERGRTDFLRLLGTDARRLIDGSENREPAAFVVRRMSFDFFRPARMDDLLEVETRVKEIGGASVTLIQTVIRDGKRIAEAEVTVVLISVSGKPLRLSDAVRNAFLAHTQAS
>NC_021172.1|WP_015598844.1|2611885_2612824_-|metallophosphoesterase
MISRRDLLKMLAALGLGSTALSSYAVAESFHERVTPYQLTPPGWTPGLNLRLAVLADLHVCEPWMSTDRVAAIVDQTNSLEPDAILLLGDYVVGRTLGRLSTPVRAGSWATALAGLKAPLGVHAVLGNHDWWDEATVQERRAGPTRAGLALEAAGIPVYQNQAIRLQKDGKPFWLAGLGDQWAFWLRAGEDDELAAKNSYRYQGVDDLPHTLAQVTDDAPVVLMAHEPDIFPQVPDRVSLTISGHTHGGQVRIFGFAPVVPSRFGSRYVYGHKIEKGRNLIVSGGLGCSSLPVRLGSPPEIVMIELGSGGEA

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_021172_1	1.2|2605676|25|NC_021172|CRISPRCasFinder	2605676-2605700	25	MN693302	Marine virus AFVG_25M270, complete genome	4143-4167	2	0.92
NC_021172_1	1.2|2605676|25|NC_021172|CRISPRCasFinder	2605676-2605700	25	NZ_CP048640	Rhizobium oryzihabitans strain M15 plasmid p8, complete sequence	36579-36603	3	0.88
NC_021172_1	1.2|2605676|25|NC_021172|CRISPRCasFinder	2605676-2605700	25	NZ_CP014290	Bacillus thuringiensis strain Bt185 plasmid pBT1850007, complete sequence	6303-6327	3	0.88
NC_021172_1	1.2|2605676|25|NC_021172|CRISPRCasFinder	2605676-2605700	25	NZ_KT290268	Enterococcus faecalis strain CK135 plasmid pPD1, complete sequence	47289-47313	4	0.84
NC_021172_1	1.2|2605676|25|NC_021172|CRISPRCasFinder	2605676-2605700	25	NZ_CP032530	Bacillus megaterium NCT-2 plasmid pNCT2_2, complete sequence	116560-116584	4	0.84
NC_021172_1	1.2|2605676|25|NC_021172|CRISPRCasFinder	2605676-2605700	25	MN692968	Marine virus AFVG_117M26, complete genome	4047-4071	4	0.84
NC_021172_1	1.2|2605676|25|NC_021172|CRISPRCasFinder	2605676-2605700	25	MN692946	Marine virus AFVG_117M27, complete genome	3372-3396	4	0.84
NC_021172_1	1.2|2605676|25|NC_021172|CRISPRCasFinder	2605676-2605700	25	MN694368	Marine virus AFVG_250M429, complete genome	3372-3396	4	0.84
NC_021172_1	1.2|2605676|25|NC_021172|CRISPRCasFinder	2605676-2605700	25	MN855735	Bacteriophage sp. isolate 111, complete genome	24815-24839	4	0.84
NC_021172_1	1.2|2605676|25|NC_021172|CRISPRCasFinder	2605676-2605700	25	KU886270	Freshwater phage uvFW-CGR-AMD-COM-C429, complete genome	34176-34200	4	0.84
NC_021172_1	1.2|2605676|25|NC_021172|CRISPRCasFinder	2605676-2605700	25	MN694254	Marine virus AFVG_250M1006, complete genome	4080-4104	4	0.84
NC_021172_1	1.2|2605676|25|NC_021172|CRISPRCasFinder	2605676-2605700	25	NC_031020	Morganella phage vB_MmoM_MP1, complete genome	157541-157565	5	0.8
NC_021172_1	1.2|2605676|25|NC_021172|CRISPRCasFinder	2605676-2605700	25	KY593455	Yersinia phage fHe-Yen9-01, complete genome	134720-134744	5	0.8
NC_021172_1	1.2|2605676|25|NC_021172|CRISPRCasFinder	2605676-2605700	25	NC_019909	Yersinia phage phiR1-RT complete genome	132799-132823	5	0.8
NC_021172_1	1.2|2605676|25|NC_021172|CRISPRCasFinder	2605676-2605700	25	MN234211	Arthrobacter phage Mimi, complete genome	40745-40769	5	0.8
NC_021172_1	1.2|2605676|25|NC_021172|CRISPRCasFinder	2605676-2605700	25	NC_011973	Bacillus cereus Q1 plasmid pBc239, complete sequence	124442-124466	6	0.76
NC_021172_1	1.2|2605676|25|NC_021172|CRISPRCasFinder	2605676-2605700	25	NZ_CP010578	Bacillus thuringiensis serovar morrisoni strain BGSC 4AA1 plasmid pBMB232, complete sequence	168559-168583	6	0.76
NC_021172_1	1.2|2605676|25|NC_021172|CRISPRCasFinder	2605676-2605700	25	NZ_CP010579	Bacillus thuringiensis serovar morrisoni strain BGSC 4AA1 plasmid pBMB92, complete sequence	8757-8781	6	0.76
NC_021172_1	1.2|2605676|25|NC_021172|CRISPRCasFinder	2605676-2605700	25	NZ_CP010579	Bacillus thuringiensis serovar morrisoni strain BGSC 4AA1 plasmid pBMB92, complete sequence	84169-84193	6	0.76
NC_021172_1	1.2|2605676|25|NC_021172|CRISPRCasFinder	2605676-2605700	25	NZ_CP020005	Bacillus thuringiensis strain Bacillus thuringiensis L-7601 plasmid unnamed3, complete sequence	401712-401736	6	0.76
NC_021172_1	1.2|2605676|25|NC_021172|CRISPRCasFinder	2605676-2605700	25	NZ_CP015177	Bacillus thuringiensis serovar alesti strain BGSC 4C1 plasmid pBMB267, complete sequence	150994-151018	6	0.76
NC_021172_1	1.2|2605676|25|NC_021172|CRISPRCasFinder	2605676-2605700	25	NZ_CP045534	Bacillaceae bacterium C02 plasmid unnamed1, complete sequence	120774-120798	6	0.76
NC_021172_1	1.2|2605676|25|NC_021172|CRISPRCasFinder	2605676-2605700	25	NZ_CP053930	Bacillus cereus strain FDAARGOS_797 plasmid unnamed1, complete sequence	67174-67198	6	0.76
NC_021172_1	1.2|2605676|25|NC_021172|CRISPRCasFinder	2605676-2605700	25	NZ_CP053953	Bacillus cereus strain FDAARGOS_798 plasmid unnamed2, complete sequence	203978-204002	6	0.76
NC_021172_1	1.2|2605676|25|NC_021172|CRISPRCasFinder	2605676-2605700	25	NZ_CP014853	Bacillus thuringiensis strain HD12 plasmid pHD120345, complete sequence	283643-283667	6	0.76
NC_021172_1	1.2|2605676|25|NC_021172|CRISPRCasFinder	2605676-2605700	25	NZ_CP040345	Bacillus albus strain DLOU-Yingkou plasmid unnamed1, complete sequence	169617-169641	6	0.76
NC_021172_1	1.2|2605676|25|NC_021172|CRISPRCasFinder	2605676-2605700	25	NZ_CP009299	Bacillus cereus D17 plasmid unnamed, complete sequence	110229-110253	6	0.76
NC_021172_1	1.2|2605676|25|NC_021172|CRISPRCasFinder	2605676-2605700	25	NZ_CP009317	Bacillus cereus 03BB102 plasmid unnamed, complete sequence	132093-132117	6	0.76
NC_021172_1	1.2|2605676|25|NC_021172|CRISPRCasFinder	2605676-2605700	25	NC_018492	Bacillus cereus FRI-35 plasmid p01, complete sequence	170124-170148	6	0.76
NC_021172_1	1.2|2605676|25|NC_021172|CRISPRCasFinder	2605676-2605700	25	NC_012473	Bacillus cereus 03BB102 plasmid p03BB102_179, complete sequence	4806-4830	6	0.76
NC_021172_1	1.2|2605676|25|NC_021172|CRISPRCasFinder	2605676-2605700	25	NC_018501	Bacillus thuringiensis HD-771 plasmid p02, complete sequence	36727-36751	6	0.76
NC_021172_1	1.2|2605676|25|NC_021172|CRISPRCasFinder	2605676-2605700	25	NZ_CP033789	Bacillus sp. FDAARGOS_527 plasmid unnamed2, complete sequence	184310-184334	6	0.76
NC_021172_1	1.2|2605676|25|NC_021172|CRISPRCasFinder	2605676-2605700	25	NZ_CP053950	Bacillus cereus strain FDAARGOS_799 plasmid unnamed2, complete sequence	98225-98249	6	0.76

1. spacer 1.2|2605676|25|NC_021172|CRISPRCasFinder matches to MN693302 (Marine virus AFVG_25M270, complete genome) position: , mismatch: 2, identity: 0.92

ttttttcttggcttcttcttcggct	CRISPR spacer
ttttttcttagcttcttcttcagct	Protospacer
*********.***********.***

2. spacer 1.2|2605676|25|NC_021172|CRISPRCasFinder matches to NZ_CP048640 (Rhizobium oryzihabitans strain M15 plasmid p8, complete sequence) position: , mismatch: 3, identity: 0.88

ttttttcttggcttcttcttcggct	CRISPR spacer
gtttttcttggcttcttcatcgggt	Protospacer
 ***************** **** *

3. spacer 1.2|2605676|25|NC_021172|CRISPRCasFinder matches to NZ_CP014290 (Bacillus thuringiensis strain Bt185 plasmid pBT1850007, complete sequence) position: , mismatch: 3, identity: 0.88

ttttttcttggcttcttcttcggct	CRISPR spacer
tattttcttggctacttcttcagct	Protospacer
* *********** *******.***

4. spacer 1.2|2605676|25|NC_021172|CRISPRCasFinder matches to NZ_KT290268 (Enterococcus faecalis strain CK135 plasmid pPD1, complete sequence) position: , mismatch: 4, identity: 0.84

ttttttcttggcttcttcttcggct	CRISPR spacer
tttttccttggcttcttcttcctca	Protospacer
*****.***************  * 

5. spacer 1.2|2605676|25|NC_021172|CRISPRCasFinder matches to NZ_CP032530 (Bacillus megaterium NCT-2 plasmid pNCT2_2, complete sequence) position: , mismatch: 4, identity: 0.84

ttttttcttggcttcttcttcggct	CRISPR spacer
atttttcttggcttcttcttttact	Protospacer
 *******************. .**

6. spacer 1.2|2605676|25|NC_021172|CRISPRCasFinder matches to MN692968 (Marine virus AFVG_117M26, complete genome) position: , mismatch: 4, identity: 0.84

ttttttcttggcttcttcttcggct	CRISPR spacer
ttttttcgtggcttcttcttcagaa	Protospacer
******* *************.*  

7. spacer 1.2|2605676|25|NC_021172|CRISPRCasFinder matches to MN692946 (Marine virus AFVG_117M27, complete genome) position: , mismatch: 4, identity: 0.84

ttttttcttggcttcttcttcggct	CRISPR spacer
ttttttcgtggcttcttcttcagaa	Protospacer
******* *************.*  

8. spacer 1.2|2605676|25|NC_021172|CRISPRCasFinder matches to MN694368 (Marine virus AFVG_250M429, complete genome) position: , mismatch: 4, identity: 0.84

ttttttcttggcttcttcttcggct	CRISPR spacer
ttttttcgtggcttcttcttcagaa	Protospacer
******* *************.*  

9. spacer 1.2|2605676|25|NC_021172|CRISPRCasFinder matches to MN855735 (Bacteriophage sp. isolate 111, complete genome) position: , mismatch: 4, identity: 0.84

ttttttcttggcttcttcttcggct	CRISPR spacer
atttttcttggcttcttcatcgtca	Protospacer
 ***************** *** * 

10. spacer 1.2|2605676|25|NC_021172|CRISPRCasFinder matches to KU886270 (Freshwater phage uvFW-CGR-AMD-COM-C429, complete genome) position: , mismatch: 4, identity: 0.84

ttttttcttggcttcttcttcggct	CRISPR spacer
ggttttcttggcttcttttttggct	Protospacer
  ***************.**.****

11. spacer 1.2|2605676|25|NC_021172|CRISPRCasFinder matches to MN694254 (Marine virus AFVG_250M1006, complete genome) position: , mismatch: 4, identity: 0.84

ttttttcttggcttcttcttcggct	CRISPR spacer
ttttttcgtggcttcttcttcagaa	Protospacer
******* *************.*  

12. spacer 1.2|2605676|25|NC_021172|CRISPRCasFinder matches to NC_031020 (Morganella phage vB_MmoM_MP1, complete genome) position: , mismatch: 5, identity: 0.8

ttttttcttggcttcttcttcggct	CRISPR spacer
aattttattggcttcttcttcggtg	Protospacer
  **** ****************. 

13. spacer 1.2|2605676|25|NC_021172|CRISPRCasFinder matches to KY593455 (Yersinia phage fHe-Yen9-01, complete genome) position: , mismatch: 5, identity: 0.8

ttttttcttggcttcttcttcggct	CRISPR spacer
aagattattggcttcttcttcggct	Protospacer
    ** ******************

14. spacer 1.2|2605676|25|NC_021172|CRISPRCasFinder matches to NC_019909 (Yersinia phage phiR1-RT complete genome) position: , mismatch: 5, identity: 0.8

ttttttcttggcttcttcttcggct	CRISPR spacer
aagattgttggcttcttcttcggct	Protospacer
    ** ******************

15. spacer 1.2|2605676|25|NC_021172|CRISPRCasFinder matches to MN234211 (Arthrobacter phage Mimi, complete genome) position: , mismatch: 5, identity: 0.8

ttttttcttggcttcttcttcggct	CRISPR spacer
gatgctcttggcttcttcttcggcg	Protospacer
  * .******************* 

16. spacer 1.2|2605676|25|NC_021172|CRISPRCasFinder matches to NC_011973 (Bacillus cereus Q1 plasmid pBc239, complete sequence) position: , mismatch: 6, identity: 0.76

ttttttcttggcttcttcttcggct	CRISPR spacer
ttttttcttggcttcttctattaga	Protospacer
******************* . .  

17. spacer 1.2|2605676|25|NC_021172|CRISPRCasFinder matches to NZ_CP010578 (Bacillus thuringiensis serovar morrisoni strain BGSC 4AA1 plasmid pBMB232, complete sequence) position: , mismatch: 6, identity: 0.76

ttttttcttggcttcttcttcggct	CRISPR spacer
ttttttcttggcttcttctattaga	Protospacer
******************* . .  

18. spacer 1.2|2605676|25|NC_021172|CRISPRCasFinder matches to NZ_CP010579 (Bacillus thuringiensis serovar morrisoni strain BGSC 4AA1 plasmid pBMB92, complete sequence) position: , mismatch: 6, identity: 0.76

ttttttcttggcttcttcttcggct	CRISPR spacer
ttttttcttggcttcttctattaga	Protospacer
******************* . .  

19. spacer 1.2|2605676|25|NC_021172|CRISPRCasFinder matches to NZ_CP010579 (Bacillus thuringiensis serovar morrisoni strain BGSC 4AA1 plasmid pBMB92, complete sequence) position: , mismatch: 6, identity: 0.76

ttttttcttggcttcttcttcggct	CRISPR spacer
ttttttcttggcttcttctattaga	Protospacer
******************* . .  

20. spacer 1.2|2605676|25|NC_021172|CRISPRCasFinder matches to NZ_CP020005 (Bacillus thuringiensis strain Bacillus thuringiensis L-7601 plasmid unnamed3, complete sequence) position: , mismatch: 6, identity: 0.76

ttttttcttggcttcttcttcggct	CRISPR spacer
ttttttcttggcttcttctattaga	Protospacer
******************* . .  

21. spacer 1.2|2605676|25|NC_021172|CRISPRCasFinder matches to NZ_CP015177 (Bacillus thuringiensis serovar alesti strain BGSC 4C1 plasmid pBMB267, complete sequence) position: , mismatch: 6, identity: 0.76

ttttttcttggcttcttcttcggct	CRISPR spacer
ttttttcttggcttcttctattaga	Protospacer
******************* . .  

22. spacer 1.2|2605676|25|NC_021172|CRISPRCasFinder matches to NZ_CP045534 (Bacillaceae bacterium C02 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.76

ttttttcttggcttcttcttcggct	CRISPR spacer
ttttttcttggcttcttctattaga	Protospacer
******************* . .  

23. spacer 1.2|2605676|25|NC_021172|CRISPRCasFinder matches to NZ_CP053930 (Bacillus cereus strain FDAARGOS_797 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.76

ttttttcttggcttcttcttcggct	CRISPR spacer
ttttttcttggcttcttctattaga	Protospacer
******************* . .  

24. spacer 1.2|2605676|25|NC_021172|CRISPRCasFinder matches to NZ_CP053953 (Bacillus cereus strain FDAARGOS_798 plasmid unnamed2, complete sequence) position: , mismatch: 6, identity: 0.76

ttttttcttggcttcttcttcggct	CRISPR spacer
ttttttcttggcttcttctattaga	Protospacer
******************* . .  

25. spacer 1.2|2605676|25|NC_021172|CRISPRCasFinder matches to NZ_CP014853 (Bacillus thuringiensis strain HD12 plasmid pHD120345, complete sequence) position: , mismatch: 6, identity: 0.76

ttttttcttggcttcttcttcggct	CRISPR spacer
ttttttcttggcttcttctattaga	Protospacer
******************* . .  

26. spacer 1.2|2605676|25|NC_021172|CRISPRCasFinder matches to NZ_CP040345 (Bacillus albus strain DLOU-Yingkou plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.76

ttttttcttggcttcttcttcggct	CRISPR spacer
ttttttcttggcttcttctattaaa	Protospacer
******************* . .  

27. spacer 1.2|2605676|25|NC_021172|CRISPRCasFinder matches to NZ_CP009299 (Bacillus cereus D17 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.76

ttttttcttggcttcttcttcggct	CRISPR spacer
ttttttcttggcttcttctattaga	Protospacer
******************* . .  

28. spacer 1.2|2605676|25|NC_021172|CRISPRCasFinder matches to NZ_CP009317 (Bacillus cereus 03BB102 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.76

ttttttcttggcttcttcttcggct	CRISPR spacer
ttttttcttggcttcttctattaga	Protospacer
******************* . .  

29. spacer 1.2|2605676|25|NC_021172|CRISPRCasFinder matches to NC_018492 (Bacillus cereus FRI-35 plasmid p01, complete sequence) position: , mismatch: 6, identity: 0.76

ttttttcttggcttcttcttcggct	CRISPR spacer
ttttttcttggcttcttctattaga	Protospacer
******************* . .  

30. spacer 1.2|2605676|25|NC_021172|CRISPRCasFinder matches to NC_012473 (Bacillus cereus 03BB102 plasmid p03BB102_179, complete sequence) position: , mismatch: 6, identity: 0.76

ttttttcttggcttcttcttcggct	CRISPR spacer
ttttttcttggcttcttctattaga	Protospacer
******************* . .  

31. spacer 1.2|2605676|25|NC_021172|CRISPRCasFinder matches to NC_018501 (Bacillus thuringiensis HD-771 plasmid p02, complete sequence) position: , mismatch: 6, identity: 0.76

ttttttcttggcttcttcttcggct	CRISPR spacer
ttttttcttggcttcttctaataaa	Protospacer
*******************   .  

32. spacer 1.2|2605676|25|NC_021172|CRISPRCasFinder matches to NZ_CP033789 (Bacillus sp. FDAARGOS_527 plasmid unnamed2, complete sequence) position: , mismatch: 6, identity: 0.76

ttttttcttggcttcttcttcggct	CRISPR spacer
ttttttcttggcttcttctattaga	Protospacer
******************* . .  

33. spacer 1.2|2605676|25|NC_021172|CRISPRCasFinder matches to NZ_CP053950 (Bacillus cereus strain FDAARGOS_799 plasmid unnamed2, complete sequence) position: , mismatch: 6, identity: 0.76

ttttttcttggcttcttcttcggct	CRISPR spacer
ttttttcttggcttcttctattaga	Protospacer
******************* . .  

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	1334050 : 1341752	9	uncultured_Mediterranean_phage(85.71%)	tRNA	NA
DBSCAN-SWA_2	1886170 : 1899915	15	Rhodobacter_phage(37.5%)	transposase,head,tail	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>NC_021172|1334050:1341752|DBSCAN-SWA
GATGATCGAAACGACAGCACAGGGCCAGACAGGCGCGCAGGGTCCGGACACTCAAGACTGGGAAGGTCCGGGCTTCGAGGATATGCCGGCGGCCGGCGAGGCGTTCGTCGTCGATATCGAGGGTTTTGAAGGTCCGCTCGACCTTTTGCTGGCGCTCGCGAGGACGCAAAAGGTCGATCTCGCGAAAATCTCCATTCTGGCGCTTGTCGAGCAGTACCTCGGATTCATTGCCGAAGCTCAGCAATTGAAGCTCGAAATTGCCGCCGACTATCTCGTCATGGCGGCGTGGCTTGCCTTTCTCAAATCGCGGCTACTGCTGCCCAAGGACAAGGAAGATCCCGACACGACGTCGGCGGAAGAACTCGCGCAGCGTCTCTCATTCCGTCTGATGCGGCTCAACGCGATGCGCGAGCAGGCGGCGACTCTGCTGACGCGGCATCGGCTCGAACGCGACGTGTTCGCACGCGGGCAACCGGAACGAATCCAGGTCACACGGGATACGACATATACCGCGACGATCTACGATCTGCTCAAAGCCTATGCCGAGCAGCGTAAGCGGACGATCAAGGTCATTCACGTCGTCAAGGCTCGGCGTGTTTGGTCGATCAAGGAAGCGCGGCAACGGCTCGAGAAGCTCGTCGGTGCGACCGCCGGGGATTGGGCGCAGCTCGACATGTTCCTCGATCAGTATCTGCCGCGCAACGAAGAGGAACGCACGGCGCTTGCCAGCTCTTTCGGGGCGACGCTCGAGATGGCGCGCGAAGGGTTAATCGAGCTTCGGCAGGACGAGCCGTTCGCTCCGATTTATATGCGCAAACGTGAAGCAGGGGCGGAGTGGGAAAAGATCGGCTAGCGCTGCCGGAAACGCCGTTATAAGGGGGGCTCGAATAGCCATGGTTCCGCCGAGACTGAGTGTCGTGTCGGACAATAGCCGCGGGATGGGTGTGATGTCGGCAAATGACGATGCCGATAATGCGCATGATCGAGCCATTCCTGACGCGCTGAGCGATCCGGAGGCCGCCGTCGATCATCTGTCGAAGAGCGCTCGGCGCGAGAAGCTCCGCCGCCTGGAGGCGCTTCTCTTTGCGTCGACCGAACCGGTTGATGCAAAAACACTGGCGCGCTGTCTCGATCCCGACGACGACGTGATAGCGCTGCTCCTGGAGCTTCAGAACGATTACAAAGATCGCGGCGTGGCGCTCGTGCGCGTCGCCGGGCGCTGGCAATTCAGGACGGCGGACGATCTTTCCTATCTGCTCGAACGGCAGCAGAAGGAAGAGCGAAAGCTTTCGAAAGCGGCGCTCGAGACATTAGCGATCATTGCCTATCACCAGCCCGTCACGCGCGCCGAGATCGAGGAAATTCGCGGTGTCTCGACGTCGCCCGGGACGCTCGACGTGCTAATGGAGACGGGTTGGATCCGACCGCGCGGGCGACGGCGGGCGCCGGGGCGGCCGCTGACCTACGGCACGACGGAAACCTTCCTGGTGCATTTCGGGCTCGATACGATCAAGGATCTGCCGGGCCTTACCGATCTCAAGGCTGCAGGCTTGCTCGACGCCAATCTGCCACCCAACTTCACGATGCCGGCGCCGACCGACGTCGCGGCCCTGATGCCGGACGAATTGCCGCTGTCTGACGACGGAGACGAGGAGGCCGAGGAAGCCCAGGAATCGCTGCCGCTCGACCATGACGACGGCGAAACCGACGGAGACTGCGACGCGGTGCCCGAGGGCAAGGCCGAGTAAGCGTGTTGCGAGGCGAAAGCCGGCCTCGAATTAATGAAATGTAATCCCACGTAAACTTCGGCGCTGCCTTTTGCCGTTTATTTTCGTGGCCGGTTCCTGGAATAAGGGGTCGCTTAAGGCAATTACGCCGAACCTTGCCCGCGACTGGCAGTTTCTGTGATAAGGTGCTTAAGCTACGGGGCGGCAACCGCCGCCGAGAGGTTACGATGGGTTTTAGCGCACAACACTTACTGCTGTTCCTGATCATTGCTTTGCTGCTGTTCGGGCGCGGCAAGATCTCCGAACTGATGGGCGATGTCGCGAAGGGCATCAAAAGCTTCAAGAAGGGTATGGCAGAGGACGATCAGCCCGAGAGGCCCGCTCCTCGTACGATCGAGAACGAAGCTTCCAATCCCGATCGCACGAAGGTCGGCTGAGAGTTCATTGCCTCGGAGCGCGTTCGCGGCTGATTCCGACAAGGTCATCTCATGTTTGACATCAGCTGGAGCGAGCTTCTGATCCTTGGGGTTGTGACGCTGGTTTTCGTCGGCCCGAAAGAGCTGCCCGCATTGATGCGCACGCTTGGCAAGTATGCCGGGGTTGTTCGCCGTCACGCGAACGAATTCAAATCGCAGTTCGATGCCGCGATGCGCGAAGCCGAACTCGAATCGATGCGGGAAGAGGTCGAGAAGATGCAAACCTCGATCAACTCAGAGGTTATGCGGGCGACGACCGACATCGACGACGCTCACAAACTCGCGCGGATCGAGCCGCCGTCCATTGTGAATACGATTGCATCGGAAAAATCTTCCGACAGGACGAAGACACTTGCACCGCCGATGCCGGCGCCGCCGCACGGGGAGACCTGAGCGATGCTGGAGCGGTTGCCGCCGTCCAAGTCTCCGGGCGATGAGCCGCCGCGCGAGGGGCAGGATGAGATCGACGCCAGCAAGGCGCCATTGCTCGACCACCTGATCGAACTCAGGCAACGTTTAATCTGGGCGCTGGCGGCATTCGTCGTGATGTTCTTCGCCTGTTTCGCGGTTGCCGGGCACATCTACAACGTGCTCGTGTGGCCGTACATGTGGGCCTCCGGCGACGAACATGTGAAACTCATCGCGACGCACTTTCTCGAACAGATCATGACGCAGGTGAAGCTGGCGATGTTCGGGGCAGCGTTCCTGTCATTTCCTATGGTCGCGACACAGATCTACAAGTTCGTCGCGCCAGGGCTTTATCGCAATGAGCGTCGAGCGTTTCTGCCTTATCTGATCGCGACGCCGGTGCTGTTCGTCATCGGTGCGATGGTCGTCTATTTCATCGCCATGCCGGTGCTGATCCGGTTTTCGATCGGGTTGGCGCAGCATAGCAGCGAAGGCGTTCCGGCGATCGAGCTCTTGCCGAAAGTTTCCGAATATCTGTCGCTGATCATGACGCTGATCTTCGGCTTCGGGATCGTATTCCAGCTTCCGGTCATTCTGACGCTGCTGGCGCGCACGGGCTTCGTGACCTCGGCGACTTTGAAAGGCGGGCGGCGCTATGCGATCGTTGCGATCTTCGCGGCGGCCGCCCTCCTGACGCCGCCGGATGCGCTCAGCATGGTGATCATGGCGTTGCCGACCATCGCGCTCTACGAAGTTTCGATTCTGGCCGTGCGCTTCGTCGAGAGGCAGCAAGCCAAGGCGGGCGTGCGCAATTAATGTGCCTTGGTCTCCTCTAGGGGTGGTGCTGGACCGCCTCCTTGGCATCGTATACGACGGCCTCTGACACACACATCGTGACGAGGCCCGCCCGTGTTCGATATCAAATGGATCAGAGACAATGCTGCAACCTTCGATGAAGGCTTGAAGCGCCGGGGCCTCCCGCCGCAGGCCGCCGCTCTGGTCGCGCTCGATGACAGGCGCCGGCAGACGCTGACGACACTGCAGGATGCGCAATCGCGCCGAAACGCGGCATCGAAGGAGATCGGCAAAGCCAAGGGTGCGAAGGACGAAGCGACGGCCGCGCGATTGATGGCCGAGGTCGCGGACTTGAAGGACATCATCGCCAAAGGCGAGGACGACGAGCGCAAGCTCGATGCCGAGATCAAGGCGGCGCTTGAAATCATTCCCAACTTGCCGCGCGCCGACGTTCCGGATGGTGCCGACGAAACGGGCAACGTCGAGGTGCGCCGCGTTGGGACGCCAGCAAGTTTCGATTTTGCACCGAAGCAGCATTTCGAGATCGGTGAAGCGCTGGGATTGATGGACTTCGAAGCGGCGCAGAAAATTTCCGGCGCACGGTTCGTCGTGTTGAAGGGAGCCCTGGCGCGTCTGGAGCGAGCGCTCGCGAGCTTCATGCTCGATCTGCATACGAGCGAGTTTGGCTACACGGAAGTCAATCCGCCGATCCTGGTCAAGGATCAGGCGGCCTATGGCACGGCCCAGTTGCCGAAGTTTGCGGAAGACCTGTTCAAGACGACGAACGATTTCTGGCTTCTTCCGACCGCCGAGATTTCGCTGACGAACCTTGTGCGCGAAGAGATTATCGACGAAGCGCAACTGCCGATGCGGGTAACGGCATGGACGCCGTGCTTCCGTTCGGAGGCGGGCGCTGCCGGCAAGGATACGCGCGGCATGATCCGCCAGCACCAATTCTCGAAGGTCGAACTCGTGTCGATCACGACACCGGACAAATCGCTTGAAGAGCACGAACGCATGACGTCATGCGCCGAGGAAGTGCTGAAACGCCTCGGCCTGCCGTTCCGCACCATCGTTCTTTGCACCGGCGACATGGGATTTGCTTCGCAGAAAACCTACGACATCGAGGTCTGGCTTCCGGGGCAAAATACCTATCGCGAGATTTCATCCTGCTCGGTGTGCGGCGACTTCCAGGCGCGGCGCATGGATGCGCGCTACCGTCCGAAGGACGGCGGCAAGCCGGTCTACGTCCATACGCTCAACGGCTCGGGTCTTGCCGTCGGCCGCACGCTGATCGCCGTGCTTGAAAACTATCAACAGGCCGACGGCAGTGTCATAATTCCCGATGCCCTCCAGCCTTACATGGGCGGCCTGAAGAGGATAGCGGCGGCCAAGACCACATGACGGGACTCTTGCCTTTCGACGTTGTCGTCATCGCTTCCGATTTTGAAGACGAAGACGTGCGAGGCAAGCGCGGACACATTATCGGCGAGGTTACGCCGACGGAAGTCGGGGTCTTCGTCTACGATCTGGAACGCGTTTGGTGCCTGCATCCCAATGATGTGCGGACTACCGGTGGGCGGGACATTGAGGCTCAAAACTATCGCGGCCCTGTGATCCGCGTGAACAGACATGGCGAGATTGTCGATTGAGCATGCGCATACTGATCACCAACGACGACGGCATCAATGCGAAGGGACTCGAAGTCCTGAAAGCGATTGCGCTCGGCATCTCGCCAGACGTGTGGACGATTGCGCCTGAGACCAATCAATCGGGCACCGCGCATTCGATGACGCTGCACACACCGCTCCGGTTGCGCACGCTCGATGAACGCACGCACGCCGTGACCGGTACGCCGACCGATTGCATCATCATGGCCGTTCGCCACATCCTGAAGCATCAGCCGCCGCAGCTCATTCTGTCCGGCGTCAACCACGGATCGAACCTTGCTGAGGACGTCACCTACTCGGGAACGGTGGCGGCGGCGATGGAAGGCGCGCTGCTCGGAATCCATTCGATCGCGCTGTCGCTGATGATGGGATTTGAAGACGGCGAGCGCCGGGCCATCTGGGATACGCCGCTCGCGCACGCGCCGCAGGTCATCAAGAGGCTGCTTGCCGAGACGTGGAATCCGCACACTCTGATGAACGTCAATTTCCCGGACACGGCGCCCGAGAACGTTGCAGGCGTTGCGGTGACCTCGCAAGGCGTTCGCGATCAGGCGTTGCTCAACATCGACAGCCGCGCCGATCCCTGGGGAACGCCCTATTTCTGGTTCGGGTTCGAGCGGCGCAAGTCGACACTGGTCGCCGGAACGGACCTCGCCGCGATTGCCGAAAATAAAATCTCGATCACGCCGTTAAGCGTCGATCTTACCGATCAAAGAGCCGCCGAAATGCTTGCATCGCGTCTCGAATGATTGCTTCGTGCGGTACAACTCTACGCTCGCAAAAGCCGCCGGAAAGCCGAAATCTCTTCGCGAATAAAGCGCAATTCTCACCTAATGGAATAACCATAGGGCGTCGTTTCACGCGCTGCCTTTCGTAATCGTTCTCCGCTTTCATTCCATGCCGAGCGTGCGAGGGGCTCGCAAATCGGCATGTACGCATCGCTACTTCTGGATTTGGGGCAAATCCCGATGGCAGCGTTTACCGCTCGTTAACCTGTTAAAGGTTAATGGATGGTGCGAGTAGAGGTGCGTACCATGATCAGTTGTTTTGGCGTAAGCCACGGCGGGCGTTTCAGCCTCAAGTCCGCAGCGGCTGTTTCCACCGTAATTGCCGGTCTCGCAATCGGGGGCTGCAGCGCGGACGTGACGCGCTTCGACAGCGCGTCCTTTAACCTAGACGATCCGTCGGATGCTCGCCCGATTCCCTCCGAGCCTATCCGGACCAGCTCGCTTAACGATAATCAGGTCGTCGGGTCGGCACCTCGGGGACCTTATGGCGCTGGCGCGTCATCGGTTCAGGTCGCGGCATTGCCGGATGCCGGTCCGAGCTATCAGCCTCCGCCGTCCTATTCGCCGCCGGCGTACACGCCTCCACCTGCTTACGCGCCTCCTGCACGATCGTACGGCGCGCAGCCGTTCGGGCGTCCGCGTTCAGAAGTAACTCCCATCGAGAGGGTTGCTCCGCAGGCGCCGGCGACGGCCAGCGGTGACGCAATCATCGTGCAACCGGGCGACACGCTCTATTCGCTGTCCCGGGCACACCATGTGTCGCTCGACGAAATGATGTCGACAAACGCGCTCAGCAATCCGAACGTCCATCCCGGCCAGAAACTCTATCTGCCTGCTGATGGCAGCGCACGGACGATGCGAAGCAGCGTCGCCGCTGCGAGGGCTGTCGAATCCGCGCGGCCCTCACCGGCTCCGCTGGCGCAGCCACCGCAGAACGTCGCCGCAAATTACAATGCGACGTATACGGTGAAGCCGGGCGAGTCGCTTTACAGTATTGCGCGCGCGCATAACGCGAAGTTTGCCGAATTGCAGCAGGTCAACGGCATCACCGATCCGCGTCGCGTGAAGCCGGGTGTCGTGCTGAAGGTGCCCGGTGGTGCGGGCGCCAATGCGCCCACGTCGCAGCAGGTCTCGACTCCTCCGCCGAGTGTTGCCGCCACTGCGCCCGCCGCTGTCGTTCCGCCGCTGGCTGCGACCGAGAAGGGATCGGATATCCCAGCATACGGTCAGTCCTTGTCGACGCAGCCGACGATCATCAACGGCGAGCATCGCGTTGCGTCTCTGACGGACAAGGCCAGCGATGCGACTCCGGCGCCCCCGCCTGCCGCCGCAACGCCGCCCGTCGCTTCGGCGGAAACTCCGGCGAGCACACAGCCCACCGCGGTTAAGCCGGAACAACCGAAGCCCGAGCAGAAAGTCGCGTTGGCAGCTCCAGCGGCAGCATCGGCAATCGCCGACAGCGTGAAGCTCCGATGGCCGACGACCGGGCGCATCATCGCCGGGTTCGGCGGGCGTCCCGATGGTACGCATAACGACGGCATCAATCTCGCCGTGCCGCTCGGCACCGAGGTCCACGCCGCAGAGTCAGGCGTCGTCGCGTATGCCGGCAACGAGCTCAAGGGCTACGGCAATCTCGTCCTGCTGCGTCACGACAACGGTTGGGTGACGGCCTACGCGCACAACGACGAGCTGCTTGTGAAGCGCGGCGATAAGGTGAAACGCGGTCAGGTCATCGCGAAAGCGGGCAAAACAGGGTCCGTCGACCAGCCGCAGGTGCATTTCGAATTGCGTCAGGGATCGAGGCCGGTGGATCCGACACCCTATCTCGAGAAGCTTTGA

Protein sequences of DBSCAN-SWA_1

>NC_021172|1334050:1341752|1340159_1341752_+|WP_015597584.1|DBSCAN-SWA
MISCFGVSHGGRFSLKSAAAVSTVIAGLAIGGCSADVTRFDSASFNLDDPSDARPIPSEPIRTSSLNDNQVVGSAPRGPYGAGASSVQVAALPDAGPSYQPPPSYSPPAYTPPPAYAPPARSYGAQPFGRPRSEVTPIERVAPQAPATASGDAIIVQPGDTLYSLSRAHHVSLDEMMSTNALSNPNVHPGQKLYLPADGSARTMRSSVAAARAVESARPSPAPLAQPPQNVAANYNATYTVKPGESLYSIARAHNAKFAELQQVNGITDPRRVKPGVVLKVPGGAGANAPTSQQVSTPPPSVAATAPAAVVPPLAATEKGSDIPAYGQSLSTQPTIINGEHRVASLTDKASDATPAPPPAAATPPVASAETPASTQPTAVKPEQPKPEQKVALAAPAAASAIADSVKLRWPTTGRIIAGFGGRPDGTHNDGINLAVPLGTEVHAAESGVVAYAGNELKGYGNLVLLRHDNGWVTAYAHNDELLVKRGDKVKRGQVIAKAGKTGSVDQPQVHFELRQGSRPVDPTPYLEKL
>NC_021172|1334050:1341752|1334050_1334902_+|WP_041320086.1|DBSCAN-SWA
MIETTAQGQTGAQGPDTQDWEGPGFEDMPAAGEAFVVDIEGFEGPLDLLLALARTQKVDLAKISILALVEQYLGFIAEAQQLKLEIAADYLVMAAWLAFLKSRLLLPKDKEDPDTTSAEELAQRLSFRLMRLNAMREQAATLLTRHRLERDVFARGQPERIQVTRDTTYTATIYDLLKAYAEQRKRTIKVIHVVKARRVWSIKEARQRLEKLVGATAGDWAQLDMFLDQYLPRNEEERTALASSFGATLEMAREGLIELRQDEPFAPIYMRKREAGAEWEKIG
>NC_021172|1334050:1341752|1336648_1337476_+|WP_015597580.1|DBSCAN-SWA
MLERLPPSKSPGDEPPREGQDEIDASKAPLLDHLIELRQRLIWALAAFVVMFFACFAVAGHIYNVLVWPYMWASGDEHVKLIATHFLEQIMTQVKLAMFGAAFLSFPMVATQIYKFVAPGLYRNERRAFLPYLIATPVLFVIGAMVVYFIAMPVLIRFSIGLAQHSSEGVPAIELLPKVSEYLSLIMTLIFGFGIVFQLPVILTLLARTGFVTSATLKGGRRYAIVAIFAAAALLTPPDALSMVIMALPTIALYEVSILAVRFVERQQAKAGVRN
>NC_021172|1334050:1341752|1337569_1338859_+|WP_015597581.1|tRNA|DBSCAN-SWA
MFDIKWIRDNAATFDEGLKRRGLPPQAAALVALDDRRRQTLTTLQDAQSRRNAASKEIGKAKGAKDEATAARLMAEVADLKDIIAKGEDDERKLDAEIKAALEIIPNLPRADVPDGADETGNVEVRRVGTPASFDFAPKQHFEIGEALGLMDFEAAQKISGARFVVLKGALARLERALASFMLDLHTSEFGYTEVNPPILVKDQAAYGTAQLPKFAEDLFKTTNDFWLLPTAEISLTNLVREEIIDEAQLPMRVTAWTPCFRSEAGAAGKDTRGMIRQHQFSKVELVSITTPDKSLEEHERMTSCAEEVLKRLGLPFRTIVLCTGDMGFASQKTYDIEVWLPGQNTYREISSCSVCGDFQARRMDARYRPKDGGKPVYVHTLNGSGLAVGRTLIAVLENYQQADGSVIIPDALQPYMGGLKRIAAAKTT
>NC_021172|1334050:1341752|1336264_1336645_+|WP_015597579.1|DBSCAN-SWA
MFDISWSELLILGVVTLVFVGPKELPALMRTLGKYAGVVRRHANEFKSQFDAAMREAELESMREEVEKMQTSINSEVMRATTDIDDAHKLARIEPPSIVNTIASEKSSDRTKTLAPPMPAPPHGET
>NC_021172|1334050:1341752|1339109_1339874_+|WP_041320088.1|DBSCAN-SWA
MRILITNDDGINAKGLEVLKAIALGISPDVWTIAPETNQSGTAHSMTLHTPLRLRTLDERTHAVTGTPTDCIIMAVRHILKHQPPQLILSGVNHGSNLAEDVTYSGTVAAAMEGALLGIHSIALSLMMGFEDGERRAIWDTPLAHAPQVIKRLLAETWNPHTLMNVNFPDTAPENVAGVAVTSQGVRDQALLNIDSRADPWGTPYFWFGFERRKSTLVAGTDLAAIAENKISITPLSVDLTDQRAAEMLASRLE
>NC_021172|1334050:1341752|1336003_1336213_+|WP_015597578.1|DBSCAN-SWA
MGFSAQHLLLFLIIALLLFGRGKISELMGDVAKGIKSFKKGMAEDDQPERPAPRTIENEASNPDRTKVG
>NC_021172|1334050:1341752|1334942_1335797_+|WP_015597577.1|DBSCAN-SWA
MVPPRLSVVSDNSRGMGVMSANDDADNAHDRAIPDALSDPEAAVDHLSKSARREKLRRLEALLFASTEPVDAKTLARCLDPDDDVIALLLELQNDYKDRGVALVRVAGRWQFRTADDLSYLLERQQKEERKLSKAALETLAIIAYHQPVTRAEIEEIRGVSTSPGTLDVLMETGWIRPRGRRRAPGRPLTYGTTETFLVHFGLDTIKDLPGLTDLKAAGLLDANLPPNFTMPAPTDVAALMPDELPLSDDGDEEAEEAQESLPLDHDDGETDGDCDAVPEGKAE
>NC_021172|1334050:1341752|1338855_1339107_+|WP_015597582.1|DBSCAN-SWA
MTGLLPFDVVVIASDFEDEDVRGKRGHIIGEVTPTEVGVFVYDLERVWCLHPNDVRTTGGRDIEAQNYRGPVIRVNRHGEIVD

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_041320086.1|1334050_1334902_+	segregation/condensation protein A	A0A1B1IVW1	uncultured_Mediterranean_phage	2.9e-30	33.3
WP_015597577.1|1334942_1335797_+	SMC-Scp complex subunit ScpB	A0A1B1IVT7	uncultured_Mediterranean_phage	8.6e-43	49.4
WP_015597578.1|1336003_1336213_+	twin-arginine translocase TatA/TatE family subunit	A0A1B1IVR9	uncultured_Mediterranean_phage	2.7e-06	57.8
WP_015597579.1|1336264_1336645_+	twin-arginine translocase subunit TatB	NA	NA	NA	NA
WP_015597580.1|1336648_1337476_+	twin-arginine translocase subunit TatC	A0A1B1IVR7	uncultured_Mediterranean_phage	1.9e-47	44.4
WP_015597581.1|1337569_1338859_+|tRNA	serine--tRNA ligase	A0A1B1IVT2	uncultured_Mediterranean_phage	2.6e-107	56.8
WP_015597582.1|1338855_1339107_+	hypothetical protein	NA	NA	NA	NA
WP_041320088.1|1339109_1339874_+	5'/3'-nucleotidase SurE	A0A1B1ITZ2	uncultured_Mediterranean_phage	8.2e-37	38.4
WP_015597584.1|1340159_1341752_+	peptidoglycan DD-metalloendopeptidase family protein	Q8SBN9	Clostridium_phage	7.7e-21	45.3

Sequences of DBSCAN-SWA_2

Nucleotide sequences of DBSCAN-SWA_2

>NC_021172|1886170:1899915|DBSCAN-SWA
ATTAACTCTTGTGCAGAGCGAGGGGGGTGTCGGCCTTGAGGCGGCCATAGATCGCCAACACCGTCCCGAACAATCCGGCGAGCGCTTGAACGGCCGTTATTGCCTGGTCGCCGAACGTCTGGATGATATCCGCCGGGAGGGCGATGCCCAAAGCCGGACCGATGGCCGGAATGACGGTCGCGGCTGCCGTGATCAGCGTCCCCCACACCGTCTTCGAACGTACCCACCATTTGCTGTCGTCATTGTCTGTGCTTTGCGTGTCGGTCGCATTACCCATCTTGCTTTCTCCTTTTGCAATTTGCCTGGGCTCGAGCAGCCCTCGGTTCGTGGCATCGGCGGCTGCCCACGTTCGTGCCAGCGCCAACGTGGCATCGACCCGCTTCAGCCAGCCGCGTCCGAAACGCCAGAAATGCGGAAGCGCGCGATAGCGCGTGCGCCGCATCTCGGCGTAGTCGTCGAGCAGATCCGAAAGACTTTTCGCGCCGATCGCAGCGAGGGTGTCAGGACCGATCTCGCCGTCAGCCGTGACGTCGACGACGCCTTGCAGCATTCGGATCGCCGCACCGACGCCGTGGTTCACGGCAGCATCGAAATGCATCAGGGCTAGGGGCGCCGTGAAAACCGGACACGAAGCAGGATCGAAGTAGCATTGCCGGTAGATCGCCGTGACCGTCGCGTCGGGGATGCGCTTCAACTCGGCAATCAGACGCGCGCGCGATACATCGTCGACGGCCTCGCTTTTAAACGCCGCGTAGGCATCGAGCGTGATTCCGCGATTGGTCGGTCCGCCCGGATCGTAGGGATCGTTCGAATAGCCGCCTTCCATGTCGAGCACATGCGCGAGCGCCTTCAGGAAGATCGTGTCGTCGCCCGTGTTCTCCGGCTCGATGTTTTCCTTGGGCCAGCGAAGCCCGAGTAACCGCGCTTTGTCGAACCCGGCAACCGTTACCGCGTCACCCTGATTGCCGCCGAGCAAATAGAGCTTGCCGTTCGTGTCGCTGAGCAGAAAGCCGACGTGTCCGGCGTTCGGGTCGTCGCCGCGCGACAGCACGACGACAGCGCCGAGCCGGGCCGCATCGAGCGGATCGCCCCAGTCAAGATACGATCTCGCCAGCAGCGAACCCGTCCCGACGTATCCGGCGCGGCGCAGCATGGCTCCGAGAAACGCCGCACACCACGGCGTCGCTTCGGTTTCAACGCTCGTGTCGCCGGCTTCGCGGAAATAACGCAGGATCTCGGGCGCATCGTCTTTGCCCGAAATTTCGCGCACGCCGAATTCGGCCCACGCGGCTGCGAGCCACGGCGGTTGGTCCATTTCTGCCTCTGAAATTTTGATCCGCTCTCTTGTGGAGGATGGCGCGAACTCTGAGTGAGCGACGCGGACCGAAAGCTTTAAACTTGCCCTACCCCCTAACCCCTCCCCGCAAGGGGAGAGGAATGGAGAGGTCGCCACCCCCACCCCTAACCCCTCCCCGCAAGGGGGAGGGGAATAAGAGCAGAGCGATTCTGCAACCAGAGCAAACCCTACAAGGAGTGTTCGTGTGCCCCTCCCCTCGACGCGGCCCGCGAGGGTGGGGAAGGGAGCGTCATGCTGGTCTACTTCTCCCCTCCCCTCGACGGGGACAGTCGTCGGGGGTGGGGTGAAAGGCTTGGCGTGCCGTCCGAGGCATGGCGCGGATCTCAGATGACGGCGGCACGGGGGACGCCGCGCCCGAAAAGCGTGTTGGTCTGAAAGACCTTCACCGAAACGGCTGATTGAACACTGCCGAAGTCGGCGATCTGATCGGCGCTCGCATAGACGATGCTCGGTGCCGATGCAGAGATCGTGCGCCTTACCGCTCCACCGTCGAGGATATCGACTTCGTATGTTTCGCTATCTTCACCGAGCGGCACATCCGGCAGTTCCCAGTTGTCGCCGCCAATCCGCGTTCGCCTGATCCAGGAAATGTTGAGATCGCCCGATGCGCGTACGCCCTTGACGTGCGCCGGCGACAACGGCCTTCGTCCAAGACCTTGATATGCGAAGGGCGTCGTCGCGTAAGAGTCGTCGCCAATATTCCGATTGCTGGGACCGTAACGCCAGTTGAGCGGCAGCTTGAGTTCGCTTTCCTGAAGCGGCACGCGCGTCACGGCGCCGTCGAGCAGAACGAATGGCGCACCTGCCGCGAGGGTATCACTCATCGCGCCTTCGGTGCCGAACTGACCACGCAATAGCCCGCTCAATTCGTAGGTTTGCGCGTCGACAAGCGTCGCATTCAGGAACTGAACGATCTCCCAATCTCCGTTACCGTTGCGAACGGCCGCCAGATTGGCGCCGCCGAGCATCGTCACAAGATCGGCAGACGCCAGCGTGCCGTATGTCAGTCGTATGCGGAGACGCGCGCCATTATCGATCAACCCTTCGGGGCCCGAAGCAAGCGGATCGAGCGTTACGCCGAGCGTCGCCGGCGCGCCCGCGAGCGCCTTCAACTGATACCCGGTCGTCTGCGGCGACATATAAAGTGCGACGCTACCGGGCCATGGCTTCTGCATTGCAGCCACGTAACCGGACTGCGCATCAGCGGACATCGTCCACGAGGGCAAATCCATGAGCGTGACGGCGGGCGTCCCCACTTGCACCAGCGCCGGTTGCGGCACCGTCCGCGCCGGCACATCAATCCGGTCATAGACATCGGGATCGACGCTGAGCGCCGCGATCTCGCGCACGCCACGCTCCGTGACGTCCGTCAGGCGCAGCAATCGGTTGCGTCCCGCGATATCAACGGAAACAACGTCTCCCGGTTCGAGCGCCAGTGCCGAGGGCGGCAACTTGAAGGACGCCCGTTCACGCGCCGCCCACGTCTCATAAAGCCAGCTTTCGACGAGCGAGCCTGCGAGCCCATCGTCGAGAACGATCGGCAGATCGGCTTCGGCAATGCGACCGCTCGCGCCCGTCAACCTTCGCGCTTCGGCAACGGCCTGCGGATAAACGTCCGCGCTCGAGATGTATCGCACCTTGGCGGACGCAGGCAGGTCGGTTTCCTGCGCGCGTGTCACCTCATAAAGCGGATCGTCGGCATGTTCTTCGACAAGGCCGTAGGCCGTCAACGTCATCTGCGGCTCGGCGCGCCCGCGATGGCGAAAGACGATTTTGCCGCCGCTTTCGATGCTGTCGAAGAAATACGCAAGGCTCAACGGCTGCAAGGCGTCGCGCGCCGACATCGTATCGTCGAGCACGTAGCCGGGCACGGTTCCGGTCAGTCCCGACGCATCGAACTCCGCGAAGTCATGATCGGTCAGAATCTGGCCGACAAGCTCGCCGAGCGAAGCGCTGCCGAGTCGACCGTTGAGCCAGTGGCCAAGCGCCCAGTTGCCGCCGTCTCCCCAATATGTCGTCGCATATGGAAATGCCGGATAGGGTCGCGCATCCCAGCAATAGACATGCATGCGGCCGAGATCGACCATGCGTGCACCGGTGATCTCCGAAACCGGATTGAGGCCCACGACGTAACCACTCTTCGTCCAATCAAATGCATCGCGCAGGACCTGCAGGAAACGCGCCTGCATGAAATCGTCTCGAATGCCGCGCGAGTAGTAGGGCAGCATCGATTCAGAACTTTTCGGATCGACAAAGACATTCGGCTGGTTGGCGCCTTTGTCGACGGCGGGGCAGCCGACCTCCATGAACCAGAACGGCTTCGACTGCGGTACCCATGCGGTCGCGGTTGCACTTTCGATGCCGCCGGGCCGATTGAAGTGCTCGTTGCTCCACCAGGAGAGAATGTCCTTGTAGCGAAACACCCACGGCTTGCCTCCTCCGTCGGTGATCGGGGTGCGAACCTGTGCGTCGCGATCGGCGCCGGACGCATAAAACCAATCGTAGCCCTCGCCGCCCTGGACGTTCGACCGCAAGTACGCCGCATCATAGATCGACATCGCGCCCGCGATGGCATCAAGGTGATCGCGTCCATCGCGCCAGTCGGCGAGCGGCCAGTAGATGTCGACGCCGATCGCATCGATATTTTCCGATGCCCAGAGCGGATCGAGATGAAAATAAACGTCGCCCGATCCGTCAGCCGGCTGATGACCGAAGTATTCCGACCAATCGGCAGCATAGAGAACCTTGGTCGATGCGCCGAGGATGGCTTTGACGTCCGCAGCCAGCGCGATCAAGGCGCTGACGAACGGATAAGTGTCGGCACTGGAGCGGACTTGCGTCAGGCCGCGCAATTCCGTGCCGATGACGAAGGTATCGACGCCGCCCGCAGCTTTCGCGAGATGCGCATGGTGCAAGACCATGCGCCGGTAGGACCACTCGTCGGGCCCGGAATATTGCACGGTACTTCCCGACAACGAGAAGTCCGTCCGCAACGCCGTTCCAACGAAAGACGCGATCTGGCTCGCAGCCGTCGTGGTCTTGTCCGGCGTGCCTGTCTTGCCGGGCGCAGGATGGCAGGTGATGCGGCCGCGCCAGGGATAGACGGGCTGGCTGCTGCCGCCATAGGGATTGGGCAGACCGTTGCCTTCCGCGACATCCATCAGGATGAACGGCGTCAGCGTCACGTTGAGCCCGCGCGATTTGAGATCGCCGATAGCGGCGATCACGGTCTGATCGGACGGTGTACCGCCGTAGGCCGCATTGCCGTCGCGCGTGCTGATGAGATGTGCGCTGGTTCTATCGCGTCCGGCGACGGACCAATCGAGTGGTGCCGTCGTTTTGTGACGCGTTTCGACGCCCGGCTCGATTCTGCAATTTCCGGCGCGCAAGTCCGTCCCGAACCAGCTGACGATCAACGACACCGACTTGGCATTCGGAAGCGATGCCTCGAGCTGGTCGACGGCCACCTGCCAATCGGTCGGGCCAATCAGCTGATGGACGTTTTCGGATTGCGAGACGCCATCATCAAACGTCTGATGAACCGGCTCCGTCGCGTAGACGAATTCGCCCGATCCCGGGATCATCACGACGCCGCGGATATCCTGCTCTACGCTCGAAACACCGCGGAAGACTTCAAACGAGAGCTGCGGCACGCGATTGCCGAACTGAGCAAGCGGCAGGCGTTCAAAGACGATATACGCGACACCGCGATAGGCTGGTGCATTCCCCACCCCGTCGCGCGCGGCGATGAGGCTATCGGGCTCTTGCGTTTCGCTGCCGGGATAGAGCCGGAATGACGTGCGCGAGAGATCAAGCTCCTGCTCGTCGGCCCAGATGCGGCCGATACGCGTCACGACGCCCTCGCCGAGCGCCACCGCGAAGTTCGCATAATAGCGATACTGCGTCAGCGTCGTGCCGCCGCCCGAACCGCCTTTGCCGCTTCCTGCGGACTCCGTCGTCGTGACGATCTCTTCTTCGAGGTCGGTCGCCCAGATGATCTGGCCTCCGACGCGCGCCCGGCCATAGATGCGCGGCAGCGGCGAACCCTCGGTCGAGGCGGTAACGCGAAGATCGCTGAGCCGCGGGCCCTCGACGGCGCGGCCTTGGCCTGAGGCGCCGAACAGCGCCGCATCGACATAGGCGCCCGCCAGCGCGCCGACTTGCGATCCGATCGTGGCACCGGACAGCGCCACGCCGAGAAAGCCGACACCTGCGGGGAGCATGCTGCTGCCGACCGCAGCTCCGACTGCCGCTAGTGCAAGCGTCGCCATGCGTAAGTCTTTCCAAATTTTATCGCTGATTGTCAGCGGCCCGAAGGCCGAGACTCGCATTCTTCTCCCCTCCCCTCCCCTCGACGGGGAGGGGTCGGGGGTGGAGTGAAGAGCCGGACGCGATGCCGAGAGCATCCTTTCGCCGAATTCATTCACCAACCGGGCACGCTGCCTATTCCGCAAGATCACTCCCGGATACTTACCCCACTCCTAGCCCCTCCCCGCAGGGGAGAGGGGAACAGGCGGAAATCGGAATGCGCCTGCGACGCGGCGGCGCCACCAGTTCGAGAAAGACACTTCACAAACCGGCGCACCTTCCATCGCGTGGATCATTGTCGAAGGGCTCGCGACGATTGCCGCGTGCTTCGCAACAACACCCGGACGCAACCGGAATATGACGGCGTCGCCCGGTTTGATATCCGACACGGAAATTCTTTTCAGATGTCGCTCCGCAGCGTCGAGCATGGTTTCCTGTCCCCCTGCTTCCGCCCAATCGCGGCTGTAAGCGGGAGGCATCTCGGCATCCGATCCGTAGACGTCGCGCCAGACGCCCCGCACGAGGCCGAGACAATCGGTGCCAATGCCACGGCGGCTCGCCTGGTGGTGATACGGCGTGCCAATCCATGCGCGCGCCGCTTCGACGATCATTGTGCGTGTCGGCCGTGTTTGCATGGATCAGCTCCGGTGCCCCACCTGCGTCAGGAATTTGTTGCCCGGCATCGACGGAAAGCCGCGAAAATTGATCACGTTAGAAAAGCGCGCCTTGCACGTCTCGATGCGCTTGTCGCACCCGGCGGTCACGACGAAGGTATCGCCCACGGCGAGCGGCCCTTCGGCATCGACCCAAAGCTCGATCACGTCGGTGGCCGCAAGCTTCATGTGCGATTTGATTTCGATCTTCAGCCCTTCGGATGCACCCGAAGTAAATTCAAAGAGCCCGCGCGAAAAAAAGCCATTCTCAAAGCCGCCGAGACCCGAGACCGTAAAGCGCCGGGCCGAGGAGGCCATAATGATCGTTCCAGTTCCGCGAAACGTTGGCGACGAGAGATCCACCTTGCAACGCGCGTCACCGAGGTCGGCGTCACAGGTCAATTGCAGAAGCCGGCCCTTCGGTTGCTGGAGATAATGCGCAAGGCCGCGAAGCTCTGCGGTAAAGCCCGTTCCGCTGCGGCGGACTTCGCCGATGCTGCCCGAACGCATCAGCACGCGCTGGCCCGTGTCGCTCCAGTTGACGCGATAGATTTCGATGCGTGCATCATCGTAGCGTCCGGCCGCGAGATCGCCGTCAGTCAAACTCGCGGAGGAGAGCGCGCCCGTCACTTCAAGATTGTCGACGGCGAGGCCGAGGCTATTTTTGATGTCGCTCGCGGTAAAGCCGCTGGCTGCCTCGTATGTCGTCCCGTCGAAGGCCAACGTCTTGTCGTGGTCCGTAAATCCCATCACGACGCTGTCCCGGCGCGCGACGCGCCAGCACCAGCAAAGAGTCGTCGCACCCGACGCGAGATGCGCGCCAAGGTCCGGTGAGAGCGCTTTCATAGGCGCACCTCGACGATCGGAATGTTCGGAATGGCGCCCGACGTGAAGCCCGACAGGTTGATTTCGAGCCTGTCGGTATCGAAGCGCACCGGAACGTCGAATTCAAATCCGGCCGTCACGCTTTGACCGACAGCAGGAATGTGGCCCGCGAGAAACGTCACGACACCCGTCGATGTATCGACGGCGAAATCCGCTTCGACATTGCACTCAACGCCGGCCACGGCAACCCGCACCGTATCTGCCACCGGCTTCTTGATGTCGCGTGCCCAAGGCGCGAATGCACTGCCGTAAATTTTATGGAGCTGGAATGTGGCCGTCATGCCGTCACCGCTTCCAATGACCTGATCGAGCGGTGTCGGCAACACATTCGGTGCACACGATTTCCAATCCATCGGATCGCGCCAGCGGAAAGCGTGCAGCCGGCCGCGCCGCTCTTCGAAGAACGCAATGATCCGGTGCAGGTCGTCGAGCGACTTGACGCCGTAGCCGGCGTTGTAGCTGCGGCGGCTGTCGGCCCAACGGCTGTTGCGTTCTTCGTATCCCGAGCCGAGCGCGACGACATCGGTGCGCCGCTCGGGGCCGCCTTGAGCGTTGCGCGAGATCGCCGTCGGAAATCTGACGTCGTGAAATGACATGAGATGACTTCGCTTTAAAGGTTACGCTGGCCCGCGGCGGCGGCGCGGGCAATCATCGCGGCAATCTGCGTCTGCGAGCGTTTGAAGCTCGCAGCGTCGGGTGTCGAGATGTTGATCGTGATGTGCTGGCCGCAGCCACCTGCCGCCGCGACGCCAAGCCGTCCATCGGAACCACGCGTCAGCGGCATTATCGCTTCCGGGCCTTTTTCTCCTGCAAGACCCGAGGCGCCGCCCGCGAGCGGAAACGAGATCGGACTCGCGATGACGCCGCCGCTGGCGAACGGTACGGGCGCGCCATTCTGAATGACGCCGCCTTTTGCGAACGGCATCGCGCCGCTGATCAACCCCTGAAACACCGAAGCCAGGCCGCTCGTCAGCGGCTGCAGCGTCGCCTTCAACGCGAGCTTGGAAATGTTGAGGGCGAGCGACTTGAAGACATCGCCGACGCTCTTGCCTTTGATCGCAAGATCGTCGAAGGCGGACACAAGCCGGTTTGAAAACTGCTGCCCGAGGCGGCTCGTCGTCGCGAGGCTCGCTTCGAGATCGCTCGTATCGGCGGTGATCTTGACATTCCACGTCTCAAGCTGCTGCTCGTCGGTCAAAGGCATCGTCCTATGTCTCGCAATCGGGGTATTGCCGCATCAGCGCGTCGAGTTCGGCTCGCGTCGGCGCCGATCCTTCGCCTGCCGTTCCGAATTTGCCGCGCAGAATGGCCTGCAGTTCGCGCGGTGTCAGCGACCAGAAGACGGCGGGGGCAAGCCCAAGCACGCCAAGCCCCATTTCCATTACGAGGTTCCAGCGAAAGGGTCGCGCGCTTCGGCGTTCGCCTCCTCGCCTCTGTCTTGATCGGCGACGGGCCCTCCGCCGAACGTCGCCGTCAATAGCCGCGCGACGATGTCGACATAACCTGCAGCACCGCCATTGCTCTGCATCGACGTGATATCGGCGTCGCTGACAGCGTGCCCGGCTCCGCGTAGCCCGGCCGCAATGACGCGCATGCAATCGCGCGCCGAGAGCCTGCCTTTTTCAAAGCGTGCAGCCAGCGCCAGCATGTCGGAATCGCCGAAGGCATCTTCGAGCTCGGCAAGCGCGCCGAGCGTCAACACGAGCTTGAAGGTTGTTCCGTCGAGTTGCGCCTCGATCTCGCCACGGTGTCTGTTGGCCATTTGGTGTCCATCAAATATCCAGGAATTCCCCTCCCCCCTTGCGGAGGGAATTATAACCTTGACTGAACAGAGCAAATTGTTATACTCAACCCAAAGTAATGATTGGGGGAGTGTTTTGATGGATCGGATTATTGCATCTGACGTAGCAGAATTTGCAAAGTCGCATGCGCTTGATGATTTGCCTGAGAACAAACAATTCGAACACTTCACCTCGTACATCACGGTCCGTCGCCATCACGCGCGTACGTTCGATACTGATGATATTGTCGTCGGCGGAAACAGTGAGCCGTCAATTGACTCAATCGCGATCATTGTGAACGGGACGCTCGTTACCGAACCATCCACAATCGACGAGCTAATCGAGAGGAATGGGTATCTCGAAGTAAACTTCGTTTTTGGTCAAGCTGACCGAGGCTCTCACTTCGACAGCAGCAAAATGGGTACCTTTGGGTACGGTGTTGAAGACTTCTTTCGCGATGAGCCGACGTTGCCGAGGGGTGAGCGGGTTCGGTTAGCCGCCGAGATTAAGGACGCGATTTTCGATCAGGGCAACAAACTCCGAAAAAAGCCTACGTGCCGGCTTTACTACGCAACGACAGGGCGCTGGAATGAGGATCAGATCCCCGTTGCAAGACGCGACGCGACCGTGACGGCAATTGAGTCCACGCAGCTTTTCAGCTCGATCGACTACCATTGCTACGGAAGCAATGAACTTCATGACCTATATGTGCGGACAAAGACTGCTGTAACCCGTGAGTTTGAGTTCAAGGAACGTCGGTCTATGCCGAAACCCGATGGCGTTAAGAGCGCGTATATCGGCTATGCTCCGGCTGCGGAGTTCATGAAGATCATCTCCGATGATAGCGGCGATGATATTCTAGGCAGCATCTTCGACGAGAACGTTCGTGATTGGCAGGACTACAACGCCGTAAACAAGGAGATGAGGGACACACTTCAGTCCCCTCATCGGGATCGTTTCGCGCTAATGAATAACGGTGTAACGATCATTACCAGCAGGATAGGCGGGGCTGGCGACGATTTGATTCTTGAAAACTTTCAGGTCGTCAACGGTTGTCAAACAAGCAACGTTCTTTTCAATGAGAGGCACGAGGACTTGAGTAAGGTTTTCGTGCCATTGCGCCTAATCGAGACTGAGGATGAGGCGGTAAAACAAGCTATCATCACCGCGACGAACCGGCAGACCGAGCTCACCACAGAACAACTTTATGCGCTGACAGATTTCTCGCGCCAGCTTGAGGATACGTTCAAAACATATGATGAGCCTGTTCGGCTATACTACGAACGGCGTGATGGGCAATACGACCGATTCCCAGAAATAAATAAAACCAAGATTGTCGTTCCCCGCGCGCTAGTGACGGCCTTCGCAGCAATGTTTCTCAACGACCCCACGAGGGTCACGAGAAACTACAAAACCATCCGGACTAAAGTAGGTGCCGAGATATTCGCTAAAGGGCACCACATCGAACCATACTACGTTGCCGCTTACGCCGCATATCGGCTCGCGTTCCTATTACGCAATAAGCTTAAGGGTGACACCGGGGCTCGCTTCCACATACTGACGGCGCTTAGGTACCTTCTCGACTCACGTCCGTTGCCGCCTATGAATCGAAATGAAATCAAGAGTCGTTGTGAGGAGATGACTAAGCTCCTTTGGGACCACGCAAAGTCGGACGAACTTTTTGCGGAGGCTTCATCTATCGTTCACAAGGTTGTTGAAGATCAGGGCCTTGAGTTCGACCGGGACAACATCCGCACCGAGGCGACCACCAAGGGGTTACTACAGCATTTTGGGATTAGGGTAGCCGATGATCGAGCGTGATGAATTTGACGAAAAAGAAGCTGCTCGTCGGCGCGACGAGGTGGTTCGCCATATGGCAAACACCCCGCCGCAACCGAAGATTAAGTCTCGACCTCATCAGGAAAAGAAAAAGAAAGCTGGCGCGGATCACGCGGCTCATAGGGACCGCGTGGACCGTGAACGTTAGAACGGAACGTCGTTCTGTCGATCATTAGATTGTTGATAGGTCACCCGCTTGCCGACGACGCCAGCAACGGCTTTTGTTGCTCGTTCCGCATCCGTAACGTTGAGTGTAGAGCGTTCGTTGTAACGGAAATCAAACTCAGCGAGATACCGCTTTAGATGCTGCGCGCTGACATGATGATAAACACCCGTGATGCCGCGCTTCATCGTTGCGAAGTAGCTTTCGATTGTGTTCGTATGAATATCGCCGCGAACGTATTCGCCGATGCTGTGATTGACCGAATGATGGTTGGGTTCGCCATGGCGAGCGCGTGCGCCGCCATCATCGCTGACCGTACGCGTAGCCTCTGCGATCTGCGCATCCATGATCGGGCGGAGCGTTTTTGCGCTGACGTTCGGGACATGGTGAGAACGGACCTTGCCGCTGCGCTCGACTAGAGCAAATACGGCTTCCTTGCCCGCACCGCCGATATTGGCCTTTTTGCGCTTACTCCGATGCTTGTTCTTTTCCTTGCCGCCAACATACGTCTCGTCAAATTCGATCGTCCTGCCACTGCCGCCAAGAGGACCATGCGACGGATTGAGGTCGCGCATGCCCTCGCGAATGCGATGCGCCATAAACCATGCGGTTTTGTACGGCAGACCGATCATCCGATGAAGCTGATGGGCGCTCATGCCCTTTTTGCTGGCACACATGAGATGTGTAGCCAGGAGCCACTTCGTCATGGGGATGTGCGAGCGCTCATAAATAGTGCCGACTGCCGCCGTGAACTTCTTGCGACAGTCCTTGCAGTGATACCAGCCGGGACCCATTGACTTGCCGCCAAGCTCTTTGACGGTCTCGCTCTGGCCGCAGAACGGGCAATGCGCGCCGTTCGGCCAGCGGATGCCCTGGAAATGCTTCCGAGCCGCGTCGGCGTCGGTGAAAATCGGGTTCGTCAGATCAGCGGTGGCAGGCATGTTCAAATCTCCTGAGAAACAACATAGCCGCTCAGGTCTGTTCAGTCAAGGTGATAATTCCCCTTGCGGAGAGGGGTTAGGGGTGGGGGTAAGGCCCAGCGCAATGCGGACTGGAGCGTGGTCGTCACGACGTCACGATTTACGTTTGATCGTCGCCTGGTTCTTCACCCCACCCCTCCCCGTCAAGGGGAGGGGAGAAGTGAGTAACAATGCGTGAGGATGACGAAGGCATCAGGACGCCGCCGTGAACGTCAGCTCGCCGGCGCTTTCGAGTGAGATGTCGAAGGTCACTTCCGCGTCGTGACGGCCGCTGAATTCGAGGGCCGTGATCTGGAACGCGCCCTGGATCGTTCCGAAATCCGGAACGATGATTTGCCAGTCGCGGATCGTGCCGTTGAATGCGTAATCGCGTATGGTCGCATCCGACGCGCCGTCCTTGAACACGCCTGACCCGGTGATGCGCGCTGACTTGACGCCGGCGCCCGTCAAAAGCTCGCGCCACTGTCCCGCGCTTTCGGTGTTGGTGATCTCGACCGTTTCCGCGCTGATCGAAAGACTGCGTGCGCGCAATCCGGCGACCGTCACGTAGACGCCCGCACCCGTCGTATCGACCTTCAGAAGAAGGTCCTTACCTTTTTGTGCTGTCATGTTTTGAGGACTCTTTTGTTTGTGCCCGGCGACTCCGCTTCGCGGAGCCGGCCGCCGGTTACGGCCTTCGTGATGCTTTGATGCCTGTTCCCGCAACGCCGCTTCGCGGAGCCGGGCCGGTTACGGGCGAGTTGTTTCGTTCCCTCTCCCCGTCCTTACGAGGAGAGGGGTAGAGTGAGGGGCGGCCGCTCATTTCCGTACTTGTTGCAGCCCCTCACCCGCCCTCTCCCCATTCCAAGTGCATCGGAATGGGGAGAGGGAGCGGTCGCGTTATTTCACTTCCGTTACGGCGCGGAAGCGGGCGATGCCGTGAAACGTTTCGCCGTCGTTGTCGCGACGGGCTTCGGAATATTCGTGCCGAAGATTGATCAACCGGTGGCCGGAGAGCGCCAGATCCTGATCGTGCAACGCGTCGCGCGCCGCCGCGATGACGGCTTCCGCTTCTTTCCTTCCGCGCGCCCGCGACCAGACGTGCAGCGTCACGAGATGCTCGTAACCTTCGTCTGTTCCGGTCGACCAGTCGCGTTCCGTCGATTGTCCGAACGTTACGAACGGAAACTCGGCGCGCGCCGGCGCATCGTCGTAGATGCGCGGGCCGCCGAGCGCGGCAAGCGTCGACGCATCGCTCGTAAGTTTCTCGAAAATCGCCTTCTGAAGCGCAAAGCCTGCACTCGACATCACTTGCCTCGCGTTTGCTGATTACGATTGTCGGCTTGGTTCACGACCTTGGGGCGCTTTTCTGCGTCAGCCTCGCGCTTGGCGATGGCTTCGCGAATGAGCGCCAAAGCCCGTGTGCGCGATGCTGATGTCGCGATGCCGCCGATACTCACATCCACTTTCATAAATCACGCTCCTCCACCGGACACTTCAGCCAGGCTCCGCGATCCTCGACGTCGATAGCGCCAAGAATGTCAAAGATGCGAACACCAAACCGGATGCGCATGTCGGGCTGGACATCGGCGCGATAGCGTATCCAGACATCGTGCGTCGCCGTTCCCGCCGTGCGATCCAGCGTAAAATTTTCATCAGCGCTTCGCGACCAGATCGCCGCCCAGACTTCGGCAACCGTTTCCCATTCTGTCGTCGATCCGCCCGCACCGTCGCTTGTGCGTTGGGCGCGCTCGATGACGATGCGGTGCCGGAGATCACCGGCTTTGACTGGTGCCTTCAT

Protein sequences of DBSCAN-SWA_2

>NC_021172|1886170:1899915|1886170_1887484_-|WP_015598113.1|DBSCAN-SWA
MDQPPWLAAAWAEFGVREISGKDDAPEILRYFREAGDTSVETEATPWCAAFLGAMLRRAGYVGTGSLLARSYLDWGDPLDAARLGAVVVLSRGDDPNAGHVGFLLSDTNGKLYLLGGNQGDAVTVAGFDKARLLGLRWPKENIEPENTGDDTIFLKALAHVLDMEGGYSNDPYDPGGPTNRGITLDAYAAFKSEAVDDVSRARLIAELKRIPDATVTAIYRQCYFDPASCPVFTAPLALMHFDAAVNHGVGAAIRMLQGVVDVTADGEIGPDTLAAIGAKSLSDLLDDYAEMRRTRYRALPHFWRFGRGWLKRVDATLALARTWAAADATNRGLLEPRQIAKGESKMGNATDTQSTDNDDSKWWVRSKTVWGTLITAAATVIPAIGPALGIALPADIIQTFGDQAITAVQALAGLFGTVLAIYGRLKADTPLALHKS
>NC_021172|1886170:1899915|1893982_1894576_-|WP_015598118.1|tail|DBSCAN-SWA
MPLTDEQQLETWNVKITADTSDLEASLATTSRLGQQFSNRLVSAFDDLAIKGKSVGDVFKSLALNISKLALKATLQPLTSGLASVFQGLISGAMPFAKGGVIQNGAPVPFASGGVIASPISFPLAGGASGLAGEKGPEAIMPLTRGSDGRLGVAAAGGCGQHITINISTPDAASFKRSQTQIAAMIARAAAAGQRNL
>NC_021172|1886170:1899915|1899421_1899586_-|WP_015598125.1|DBSCAN-SWA
MKVDVSIGGIATSASRTRALALIREAIAKREADAEKRPKVVNQADNRNQQTRGK
>NC_021172|1886170:1899915|1892472_1893333_-|WP_015598116.1|DBSCAN-SWA
MKALSPDLGAHLASGATTLCWCWRVARRDSVVMGFTDHDKTLAFDGTTYEAASGFTASDIKNSLGLAVDNLEVTGALSSASLTDGDLAAGRYDDARIEIYRVNWSDTGQRVLMRSGSIGEVRRSGTGFTAELRGLAHYLQQPKGRLLQLTCDADLGDARCKVDLSSPTFRGTGTIIMASSARRFTVSGLGGFENGFFSRGLFEFTSGASEGLKIEIKSHMKLAATDVIELWVDAEGPLAVGDTFVVTAGCDKRIETCKARFSNVINFRGFPSMPGNKFLTQVGHRS
>NC_021172|1886170:1899915|1887849_1891797_-|WP_041320242.1|tail|DBSCAN-SWA
MATLALAAVGAAVGSSMLPAGVGFLGVALSGATIGSQVGALAGAYVDAALFGASGQGRAVEGPRLSDLRVTASTEGSPLPRIYGRARVGGQIIWATDLEEEIVTTTESAGSGKGGSGGGTTLTQYRYYANFAVALGEGVVTRIGRIWADEQELDLSRTSFRLYPGSETQEPDSLIAARDGVGNAPAYRGVAYIVFERLPLAQFGNRVPQLSFEVFRGVSSVEQDIRGVVMIPGSGEFVYATEPVHQTFDDGVSQSENVHQLIGPTDWQVAVDQLEASLPNAKSVSLIVSWFGTDLRAGNCRIEPGVETRHKTTAPLDWSVAGRDRTSAHLISTRDGNAAYGGTPSDQTVIAAIGDLKSRGLNVTLTPFILMDVAEGNGLPNPYGGSSQPVYPWRGRITCHPAPGKTGTPDKTTTAASQIASFVGTALRTDFSLSGSTVQYSGPDEWSYRRMVLHHAHLAKAAGGVDTFVIGTELRGLTQVRSSADTYPFVSALIALAADVKAILGASTKVLYAADWSEYFGHQPADGSGDVYFHLDPLWASENIDAIGVDIYWPLADWRDGRDHLDAIAGAMSIYDAAYLRSNVQGGEGYDWFYASGADRDAQVRTPITDGGGKPWVFRYKDILSWWSNEHFNRPGGIESATATAWVPQSKPFWFMEVGCPAVDKGANQPNVFVDPKSSESMLPYYSRGIRDDFMQARFLQVLRDAFDWTKSGYVVGLNPVSEITGARMVDLGRMHVYCWDARPYPAFPYATTYWGDGGNWALGHWLNGRLGSASLGELVGQILTDHDFAEFDASGLTGTVPGYVLDDTMSARDALQPLSLAYFFDSIESGGKIVFRHRGRAEPQMTLTAYGLVEEHADDPLYEVTRAQETDLPASAKVRYISSADVYPQAVAEARRLTGASGRIAEADLPIVLDDGLAGSLVESWLYETWAARERASFKLPPSALALEPGDVVSVDIAGRNRLLRLTDVTERGVREIAALSVDPDVYDRIDVPARTVPQPALVQVGTPAVTLMDLPSWTMSADAQSGYVAAMQKPWPGSVALYMSPQTTGYQLKALAGAPATLGVTLDPLASGPEGLIDNGARLRIRLTYGTLASADLVTMLGGANLAAVRNGNGDWEIVQFLNATLVDAQTYELSGLLRGQFGTEGAMSDTLAAGAPFVLLDGAVTRVPLQESELKLPLNWRYGPSNRNIGDDSYATTPFAYQGLGRRPLSPAHVKGVRASGDLNISWIRRTRIGGDNWELPDVPLGEDSETYEVDILDGGAVRRTISASAPSIVYASADQIADFGSVQSAVSVKVFQTNTLFGRGVPRAAVI
>NC_021172|1886170:1899915|1897136_1898096_-|WP_015598122.1|transposase|DBSCAN-SWA
MPATADLTNPIFTDADAARKHFQGIRWPNGAHCPFCGQSETVKELGGKSMGPGWYHCKDCRKKFTAAVGTIYERSHIPMTKWLLATHLMCASKKGMSAHQLHRMIGLPYKTAWFMAHRIREGMRDLNPSHGPLGGSGRTIEFDETYVGGKEKNKHRSKRKKANIGGAGKEAVFALVERSGKVRSHHVPNVSAKTLRPIMDAQIAEATRTVSDDGGARARHGEPNHHSVNHSIGEYVRGDIHTNTIESYFATMKRGITGVYHHVSAQHLKRYLAEFDFRYNERSTLNVTDAERATKAVAGVVGKRVTYQQSNDRQNDVPF
>NC_021172|1886170:1899915|1899014_1899422_-|WP_015598124.1|DBSCAN-SWA
MSSAGFALQKAIFEKLTSDASTLAALGGPRIYDDAPARAEFPFVTFGQSTERDWSTGTDEGYEHLVTLHVWSRARGRKEAEAVIAAARDALHDQDLALSGHRLINLRHEYSEARRDNDGETFHGIARFRAVTEVK
>NC_021172|1886170:1899915|1898327_1898744_-|WP_015598123.1|tail|DBSCAN-SWA
MTAQKGKDLLLKVDTTGAGVYVTVAGLRARSLSISAETVEITNTESAGQWRELLTGAGVKSARITGSGVFKDGASDATIRDYAFNGTIRDWQIIVPDFGTIQGAFQITALEFSGRHDAEVTFDISLESAGELTFTAAS
>NC_021172|1886170:1899915|1895252_1896974_+|WP_041320245.1|DBSCAN-SWA
MDRIIASDVAEFAKSHALDDLPENKQFEHFTSYITVRRHHARTFDTDDIVVGGNSEPSIDSIAIIVNGTLVTEPSTIDELIERNGYLEVNFVFGQADRGSHFDSSKMGTFGYGVEDFFRDEPTLPRGERVRLAAEIKDAIFDQGNKLRKKPTCRLYYATTGRWNEDQIPVARRDATVTAIESTQLFSSIDYHCYGSNELHDLYVRTKTAVTREFEFKERRSMPKPDGVKSAYIGYAPAAEFMKIISDDSGDDILGSIFDENVRDWQDYNAVNKEMRDTLQSPHRDRFALMNNGVTIITSRIGGAGDDLILENFQVVNGCQTSNVLFNERHEDLSKVFVPLRLIETEDEAVKQAIITATNRQTELTTEQLYALTDFSRQLEDTFKTYDEPVRLYYERRDGQYDRFPEINKTKIVVPRALVTAFAAMFLNDPTRVTRNYKTIRTKVGAEIFAKGHHIEPYYVAAYAAYRLAFLLRNKLKGDTGARFHILTALRYLLDSRPLPPMNRNEIKSRCEEMTKLLWDHAKSDELFAEASSIVHKVVEDQGLEFDRDNIRTEATTKGLLQHFGIRVADDRA
>NC_021172|1886170:1899915|1893329_1893968_-|WP_015598117.1|DBSCAN-SWA
MSFHDVRFPTAISRNAQGGPERRTDVVALGSGYEERNSRWADSRRSYNAGYGVKSLDDLHRIIAFFEERRGRLHAFRWRDPMDWKSCAPNVLPTPLDQVIGSGDGMTATFQLHKIYGSAFAPWARDIKKPVADTVRVAVAGVECNVEADFAVDTSTGVVTFLAGHIPAVGQSVTAGFEFDVPVRFDTDRLEINLSGFTSGAIPNIPIVEVRL
>NC_021172|1886170:1899915|1892007_1892469_-|WP_015598115.1|DBSCAN-SWA
MQTRPTRTMIVEAARAWIGTPYHHQASRRGIGTDCLGLVRGVWRDVYGSDAEMPPAYSRDWAEAGGQETMLDAAERHLKRISVSDIKPGDAVIFRLRPGVVAKHAAIVASPSTMIHAMEGAPVCEVSFSNWWRRRVAGAFRFPPVPLSPAGRG
>NC_021172|1886170:1899915|1896960_1897140_+|WP_041320247.1|DBSCAN-SWA
MIERDEFDEKEAARRRDEVVRHMANTPPQPKIKSRPHQEKKKKAGADHAAHRDRVDRER
>NC_021172|1886170:1899915|1894753_1895134_-|WP_015598120.1|DBSCAN-SWA
MANRHRGEIEAQLDGTTFKLVLTLGALAELEDAFGDSDMLALAARFEKGRLSARDCMRVIAAGLRGAGHAVSDADITSMQSNGGAAGYVDIVARLLTATFGGGPVADQDRGEEANAEARDPFAGTS
>NC_021172|1886170:1899915|1894580_1894754_-|WP_015598119.1|tail|DBSCAN-SWA
MEMGLGVLGLAPAVFWSLTPRELQAILRGKFGTAGEGSAPTRAELDALMRQYPDCET
>NC_021172|1886170:1899915|1899582_1899915_-|WP_015598126.1|head|DBSCAN-SWA
MKAPVKAGDLRHRIVIERAQRTSDGAGGSTTEWETVAEVWAAIWSRSADENFTLDRTAGTATHDVWIRYRADVQPDMRIRFGVRIFDILGAIDVEDRGAWLKCPVEERDL

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015598113.1|1886170_1887484_-	TIGR02594 family protein	A0A222YWL8	Escherichia_phage	1.4e-28	44.9
WP_041320242.1|1887849_1891797_-|tail	glycoside hydrolase/phage tail family protein	A0A0K1LLC1	Rhodobacter_phage	6.6e-255	42.7
WP_015598115.1|1892007_1892469_-	C40 family peptidase	F4YXU4	Roseobacter_phage	4.5e-30	41.8
WP_015598116.1|1892472_1893333_-	DUF2163 domain-containing protein	A0A0K0PVK1	Roseobacter_phage	1.6e-73	49.6
WP_015598117.1|1893329_1893968_-	DUF2460 domain-containing protein	A0A0K1Y6G4	Rhodobacter_phage	1.2e-46	48.2
WP_015598118.1|1893982_1894576_-|tail	phage tail tape measure protein	E7EKW4	Edwardsiella_phage	9.0e-07	35.1
WP_015598119.1|1894580_1894754_-|tail	phage tail assembly chaperone	NA	NA	NA	NA
WP_015598120.1|1894753_1895134_-	gene transfer agent family protein	NA	NA	NA	NA
WP_041320245.1|1895252_1896974_+	AIPR family protein	NA	NA	NA	NA
WP_041320247.1|1896960_1897140_+	hypothetical protein	NA	NA	NA	NA
WP_015598122.1|1897136_1898096_-|transposase	IS1595 family transposase	NA	NA	NA	NA
WP_015598123.1|1898327_1898744_-|tail	phage major tail protein, TP901-1 family	I3UM07	Rhodobacter_phage	4.6e-18	38.2
WP_015598124.1|1899014_1899422_-	DUF3168 domain-containing protein	NA	NA	NA	NA
WP_015598125.1|1899421_1899586_-	hypothetical protein	NA	NA	NA	NA
WP_015598126.1|1899582_1899915_-|head	phage head closure protein	Q3HQT3	Burkholderia_phage	6.6e-07	32.0