CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_017620	Streptococcus suis D9, complete sequence	2 crisprs	DinG,csn2,cas2,cas1,cas9,csa3,cas3,DEDDh	6	2	12	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_017620_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017620_1

1450212-1450580

TypeII

Consensus_repeat	Method
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAACTTA	PILER-CR

5 spacers

csn2,cas2,cas1,cas9

The CRISPR arrays of NC_017620_1

>merge|NC_017620|1|1450212-1450580|PILER-CR
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAACTTAGAATATTCTCAGCAAGTAAACACTGATGTTTTACTGTTACTTAAATCTTGAGAGTACAAAAACTTAGAATATTCTCAGCAAGTAAACACTGATGTTTTACTGTTACTTAAATCTTGAGAGTACAAAAACTTAGAATATTCTCAGCAAGTAAACACTGATGTTTTACTGTTACTTAAATCTTGAGAGTACAAAAACTTAGAATATTCTCAGCAAGTAAACACTGATGTTTTACTGTTACTTAAATCTTGAGAGTACAAAAACTTAGAATATTCTCAGCAAGTAAACACTGATGTTTTACTGTTACTTAAATCTTGAGAGTACAAAAACCGA

>NC_017620|1|1|1450212-1450580|PILER-CR
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAACTTA	GAATATTCTCAGCAAGTAAACACTGAT
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAACTTA	GAATATTCTCAGCAAGTAAACACTGAT
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAACTTA	GAATATTCTCAGCAAGTAAACACTGAT
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAACTTA	GAATATTCTCAGCAAGTAAACACTGAT
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAACTTA	GAATATTCTCAGCAAGTAAACACTGAT
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAACCGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_017620.1\|WP_002935570.1\|1440557_1441298_-\|acyl-ACP-thioesterase	unknown	unknown	gnl\|CDD\|366738
NC_017620.1\|WP_002935608.1\|1460369_1461743_+\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE	unknown	unknown	gnl\|CDD\|235392
NC_017620.1\|WP_002935598.1\|1453873_1454920_-\|hypothetical-protein	csn2	cd12217_csn2_CAS-II-A	gnl\|CDD\|213410
NC_017620.1\|WP_002935583.1\|1445906_1446620_-\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|180275
NC_017620.1\|WP_002935569.1\|1439953_1440571_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|240029
NC_017620.1\|WP_002935587.1\|1447473_1447830_-\|ArsC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|239332
NC_017620.1\|WP_002935621.1\|1464924_1465506_-\|LemA-family-protein	unknown	unknown	gnl\|CDD\|377192
NC_017620.1\|WP_002935618.1\|1463449_1464913_-\|flotillin-family-protein	unknown	unknown	gnl\|CDD\|259798
NC_017620.1\|WP_009910385.1\|1443463_1445731_-\|glycogen/starch/alpha-glucan-family-phosphorylase	unknown	unknown	gnl\|CDD\|340853
NC_017620.1\|WP_002935597.1\|1449369_1450044_-\|ribose-5-phosphate-isomerase-RpiA	unknown	unknown	gnl\|CDD\|234816
NC_017620.1\|WP_014637067.1\|1456317_1459686_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	cd09643_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|273840
NC_017620.1\|WP_002935585.1\|1446652_1447462_-\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|236183
NC_017620.1\|WP_014637063.1\|1447829_1449041_-\|phosphopentomutase	unknown	unknown	gnl\|CDD\|235430
NC_017620.1\|WP_014637065.1\|1451756_1453046_-\|IS4-like-element-ISSsu2-family-transposase	unknown	unknown	gnl\|CDD\|376573
NC_017620.1\|WP_002935599.1\|1454916_1455240_-\|CRISPR-associated-endonuclease-Cas2	cas2	COG3512_cas2_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|226043
NC_017620.1\|WP_002935611.1\|1461854_1462931_+\|hypothetical-protein	unknown	unknown	unknown
NC_017620.1\|WP_002935571.1\|1441528_1442656_-\|oxygen-independent-coproporphyrinogen-III-oxidase	unknown	unknown	gnl\|CDD\|236309
NC_017620.1\|WP_002935572.1\|1442750_1443329_+\|teicoplanin-resistance-protein-VanZ	unknown	unknown	gnl\|CDD\|377417
NC_017620.1\|WP_002935600.1\|1455236_1456151_-\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|274694
NC_017620.1\|WP_009910392.1\|1463052_1463361_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_017620.1\|WP_002935570.1\|1440557_1441298_-\|acyl-ACP-thioesterase	gnl\|CDD\|366738	pfam01643, Acyl-ACP_TE, Acyl-ACP thioesterase. This family consists of various acyl-acyl carrier protein (ACP) thioesterases (TE) these terminate fatty acyl group extension via hydrolysing an acyl group on a fatty acid.	7.63063e-88
NC_017620.1\|WP_002935608.1\|1460369_1461743_+\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE	gnl\|CDD\|235392	PRK05291, trmE, tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE.	0
NC_017620.1\|WP_002935598.1\|1453873_1454920_-\|hypothetical-protein	gnl\|CDD\|213410	cd12217, Stu0660_Csn2, Stu0660-like CRISPR/Cas system-associated protein Csn2. Csn2 is a Nmeni subtype-specific Cas protein, which may function in the adaptation process which mediates the incorporation of foreign nucleic acids into the microbial host genome. Csn 2 may interact directly with double-stranded DNA. This family of Csn2 proteins includes Stu0660, the proteins are larger than other (canonical) Csn2 proteins as they have an additional alpha-helical C-terminal domain. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Csn2 has been predicted to be a functional analog of Cas4 based on anti-correlated phyletic patterns; also known as SPy1049 family.	2.6417e-137
NC_017620.1\|WP_002935583.1\|1445906_1446620_-\|purine-nucleoside-phosphorylase	gnl\|CDD\|180275	PRK05819, deoD, DeoD-type purine-nucleoside phosphorylase.	4.90632e-151
NC_017620.1\|WP_002935569.1\|1439953_1440571_-\|NUDIX-hydrolase	gnl\|CDD\|240029	cd04672, Nudix_Hydrolase_14, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	3.31442e-61
NC_017620.1\|WP_002935587.1\|1447473_1447830_-\|ArsC-family-transcriptional-regulator	gnl\|CDD\|239332	cd03034, ArsC_ArsC, Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the detoxification of arsenic, using reducing equivalents derived from glutathione (GSH) via glutaredoxin (GRX). ArsC contains a single catalytic cysteine, within a thioredoxin fold, that forms a covalent thiolate-As(V) intermediate, which is reduced by GRX through a mixed GSH-arsenate intermediate. This family of predominantly bacterial enzymes is unrelated to two other families of arsenate reductases which show similarity to low-molecular-weight acid phosphatases and phosphotyrosyl phosphatases.	1.02902e-20
NC_017620.1\|WP_002935618.1\|1463449_1464913_-\|flotillin-family-protein	gnl\|CDD\|259798	cd03399, SPFH_flotillin, Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily. The flotillin (reggie) like proteins are lipid raft-associated. Individual proteins of this SPFH family may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. In addition, microdomains formed from flotillin proteins may be dynamic units with their own regulatory functions. Flotillins have been implicated in signal transduction, vesicle trafficking, cytoskeleton rearrangement and interact with a variety of proteins. They may play a role in the progression of prion disease, in the pathogenesis of neurodegenerative diseases such as Parkinson's and Alzheimer's disease and in cancer invasion, and metastasis.	7.80101e-47
NC_017620.1\|WP_009910385.1\|1443463_1445731_-\|glycogen/starch/alpha-glucan-family-phosphorylase	gnl\|CDD\|340853	cd04300, GT35_Glycogen_Phosphorylase, glycogen phosphorylase and similar proteins. This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of oligosaccharides into glucose-1-phosphate units. They are important allosteric enzymes in carbohydrate metabolism. The allosteric control mechanisms of yeast and mammalian members of this family are different from that of bacterial members. The members of this family belong to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.	0
NC_017620.1\|WP_002935597.1\|1449369_1450044_-\|ribose-5-phosphate-isomerase-RpiA	gnl\|CDD\|234816	PRK00702, PRK00702, ribose-5-phosphate isomerase RpiA.	1.32327e-114
NC_017620.1\|WP_014637067.1\|1456317_1459686_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	gnl\|CDD\|273840	TIGR01865, conserved_hypothetical_protein, CRISPR subtype II/NMENI RNA-guided endonuclease Cas9/Csn1. CRISPR loci appear to be mobile elements with a wide host range. This model represents a protein found only in CRISPR-containing species, near other CRISPR-associated proteins (cas), as part of the NMENI subtype of CRISPR/Cas locus. The species range so far for this protein is animal pathogens and commensals only.	6.97095e-177
NC_017620.1\|WP_002935585.1\|1446652_1447462_-\|purine-nucleoside-phosphorylase	gnl\|CDD\|236183	PRK08202, PRK08202, purine nucleoside phosphorylase; Provisional.	6.03224e-162
NC_017620.1\|WP_014637063.1\|1447829_1449041_-\|phosphopentomutase	gnl\|CDD\|235430	PRK05362, PRK05362, phosphopentomutase; Provisional.	0
NC_017620.1\|WP_014637065.1\|1451756_1453046_-\|IS4-like-element-ISSsu2-family-transposase	gnl\|CDD\|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	3.58383e-08
NC_017620.1\|WP_002935599.1\|1454916_1455240_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	9.7745e-25
NC_017620.1\|WP_002935621.1\|1464924_1465506_-\|LemA-family-protein	gnl\|CDD\|377192	pfam04011, LemA, LemA family. The members of this family are related to the LemA protein. LemA contains an amino terminal predicted transmembrane helix. It has been predicted that the small amino terminus is extracellular. The exact molecular function of this protein is uncertain.	8.85941e-67
NC_017620.1\|WP_002935571.1\|1441528_1442656_-\|oxygen-independent-coproporphyrinogen-III-oxidase	gnl\|CDD\|236309	PRK08599, PRK08599, oxygen-independent coproporphyrinogen III oxidase.	0
NC_017620.1\|WP_002935572.1\|1442750_1443329_+\|teicoplanin-resistance-protein-VanZ	gnl\|CDD\|377417	pfam04892, VanZ, VanZ like family. This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.	9.00811e-06
NC_017620.1\|WP_002935600.1\|1455236_1456151_-\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274694	TIGR03639, cas1_NMENI, CRISPR-associated endonuclease Cas1, subtype II/NMENI. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is a prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 variant of the NMENI subtype of CRISPR/Cas system.	2.0775e-122

>NC_017620.1|WP_002935597.1|1449369_1450044_-|ribose-5-phosphate-isomerase-RpiA
MTNLKEQVGIKAAEFVTDGMIVGLGTGSTAYYFVQEIGRRVAEEGLQITGVTTSHATAEHAASLGIPLKNIDEVEYVDLTVDGADEVDGDFNGIKGGGAALLMEKVVAVNSKDCIWIVDESKVVQTLGAFKLPVEVVQYGAENLFRLFEKKGYRPSFRMRNGEKHITDMQNFIIDLDLRRIEDTYALAEELDRTVGVVEHGLFIGLISKVIVGTPEGPNIIEKK
>NC_017620.1|WP_014637063.1|1447829_1449041_-|phosphopentomutase
MPKFKRVHLVVMDSVGIGAAPDSDKFFNAGVADTESDTLGHISEKAGLEVPNMTKIGLGNIPRDTALATVPAESHPTGYVTKLEEVSLGKDTMTGHWEIMGLNITEPFDTFWDGFPEEILTKIEEFSGRKIIREANKPYSGTAVIDDFGPRQMETGELIVYTSADPVLQIAAHEDIIPLDELYRICEYARSITLERPALLGRIIARPYVGEPGNFSRTANRHDYAVSPFEETVLNKLADAGVPTYSVGKISDIFNGSGITNDMGHTKSNMHGVDVLIDTLKLSDFEEGFSFTNLVDFDAVYGHRRNIEGYRDCLQEFDARIPEIIDNMREDDLLLITADHGNDPSYAGTDHTREYVPLLAYSKVFKGSGVLPVGHFADISATVAENFGVDTAMIGESFLSQLV
>NC_017620.1|WP_002935587.1|1447473_1447830_-|ArsC-family-transcriptional-regulator
MEKLTVYYNPDCSKCKKLRILLPSQDMEVKWVNYLETPLRGAELTALLEKMGSQPSAVTRLKEEERLALPEEEIFERLVKEPALLNRPIIEREQTAFLCRPLEIIKEKMPEYDWSDYL
>NC_017620.1|WP_002935585.1|1446652_1447462_-|purine-nucleoside-phosphorylase
MSLLAKINETKTFLEEKGLVKPEFGLILGSGLGELAQEVENAIVIDYADIPNWGKSTVVGHAGKLVYGDLAGRKVLALQGRFHFYEGNPMEVVTFPVRVMKALGCEGVIVTNAAGGIGYGPGTLMAITDHINMTGQNPLIGENLEEFGPRFPDMSNAYTKEYREKAHAVAEKLGIKLDDGVYLGVTGPTYETPAEILAFKTMGAHAVGMSTVPEVIVAAHSGMKVLGISAITNFAAGFQSELNHEEVVEVTEQIKGNFKGLVKAILAEL
>NC_017620.1|WP_002935583.1|1445906_1446620_-|purine-nucleoside-phosphorylase
MSIHISAKPGEIADKILLPGDPLRAKFIAENFLEDAVCFNEVRNMFGYTGTYKGHRVSVMGTGMGMPSISIYAHELINEYGVKKLIRVGTAGSLNEDVHVRELVLAQAAATNSRMINIDWPEYDLPQIADFDLLDKAYHIAKELNMTTHVGNVLSSDSFYSPKLFSRNLELGQLGVKAVEMEAAALYYLGAKFGVQTLAIMTISDSLVNPEENTTAEERQNTFTDMMKVGLETLIAE
>NC_017620.1|WP_009910385.1|1443463_1445731_-|glycogen/starch/alpha-glucan-family-phosphorylase
MINLQNFVQSMYAKRIEDCTDQELYYALLAFTKQQSEAKYTNDQKKKVYYISAEFLIGKLLSNNLINLGLYDEVKSQLVAAGKDLIAIEDMELEPSLGNGGLGRLAACFLDSIASLGLNGDGVGLNYHFGLFRQLFEYHQQSAVPNEWITPRSWLTESPISYQVPFANFTLTSKLYDIDVPGYKMERKNRLRLFDLGSVDDNIIYDGIEFDKEDIFRNLTLFLYPDDSTDEGKVLRIFQQYFMVSNAAQLLIDEAVAKGSNLHDLPDYAVVQINDTHPSLVIPELIRLLELRGISFDEAVEIVKKMTAYTNHTILSEALEKWPLDFLNYVVPHLVPFIVELDRRAKEVKDDPAVNIIDEYGRVHMAHMDIHYGYSINGVAALHTEILKTSELKAFYELYPEKFNNKTNGITFRRWLMHANPSLASYLDGLLGHGYHHDASELEKLLDYKNDKELKSWLEKTKQHNKRKLQRHIAKTQGVHVNPESIFDVQIKRMHEYKRQQMNVLYVIHKYLDIKAGNIPTRPLTVFFGGKAAPAYTTAQDIIHLILVLSQVIKNDSEVAPHLQLVMIENYNVTEASFIIPAADISEQISLASKEASGTGNMKFMLNGALTIGTDDGANVEIHELVGDENIYIFGQDSQTVIEHYANRTYHPYSFYEREVIRPLIDFITSDTIRHAGGIDERLWRLQDNLKHNDHFMTLLDLEDYIVTKERMLADYEDRDSWLEKVIVNIAKAGFFSSDRTIQQYNEDIWHLEAK
>NC_017620.1|WP_002935572.1|1442750_1443329_+|teicoplanin-resistance-protein-VanZ
MKKEIIYDCINLILSFLLCRWLFMTFLFYQFSNIFMTIDFWPTLAAILLMTGFCFTLFRLVYKPHISRLTLWFFYACYGLLLVYLLFFKSMGVRGVNWNLLSTFSQDLFLNPTILVFNLLLFLPLGLLFSFSWKKLSLFVGAILLVEACQFFFSLGFFDLGDILLNTSGFALGNFLGQSAIAQSFKNRIQKK
>NC_017620.1|WP_002935571.1|1441528_1442656_-|oxygen-independent-coproporphyrinogen-III-oxidase
MKKRPTSAYIHIPFCTQICYYCDFSKVFIKNQPVDEYLAALMEEVKFYDLPALRTLYIGGGTPSALSADQLDYLLTNLEDLLDLSQLEEFTIEANPGDLTADKIAVLKKSKCNRVSLGVQTFDDRMLKKIGRSHNQAQIYETIATLKEAGFYNISIDLIYALPGQTMEQVVDNVAKALELDIPHMSLYSLILENHTVFMNRQRRGNLHLPNEDVESDMFDYILQELEKNGFEHYEISNFTKPGFESRHNLMYWDNSEYYGLGAGASGYIDGMRYRNRGPIQHYLKSIREKGHSRLHEEFLSQTEQMEEEMFLGLRKKTGVSIERFEEKFGISFEDRYGQVVRDLKNEGLLQEEDRWLRMTKKGLFLGDTVAERFI
>NC_017620.1|WP_002935570.1|1440557_1441298_-|acyl-ACP-thioesterase
MGLTYQEEFTIPFDMVDVKQEIKLPDFISYCLGVSGRQSEELGRSDLYVFQEFGLIWVVTDYELTIQRLPKYNETITIKTEAVAYNKFFCHRMFYIYDAAGNLLLDILCYFVLIDFETRKVAPVPEDLIAPYQSEQVKKLPRAPKYQLLENPSVQEFPVRYFDLDMNGHVNNGKYLEWMYEALGYDFLLCHVPKKIQLKYLKEVEATSLVSSRMVAEAGGSQHEIVVDGHIHAQAVIEWRERHVAG
>NC_017620.1|WP_002935569.1|1439953_1440571_-|NUDIX-hydrolase
MSQDKWLEWAVRLQALAQTGLAYGKDVYDMERFEEIRQIAAEMLVEPSGQPLEVVKDLFCNETGYQTPKLDTRAAIFQEDKILLVQENDGLWSLPGGWCDVDQSVKDNVVKEVKEEAGLDVEAQRVVAILDKHKNNPAKSAHRVTKVFILCRLLGGEFQPNSETVASGFFSLDDLPPLYLGKNTAEQLALCLEASRSEHWETRFD
>NC_017620.1|WP_014637065.1|1451756_1453046_-|IS4-like-element-ISSsu2-family-transposase
MLDQIKAHLLDSINDIVSSANQFVLHPEKDFSRQSQLTMKTMIQAILTMGGNTLAKELLDLDLPVSQSAFVQRRYQIKHQAFKTLFRDITSKIPISDNLPILAVDGSDMILPRNRFDKTTSFQTGPHHTPYNLIHINALYNLEQEIYHDLRIQDNREVDERAAFIDMMKTSSFKQALVIMDRGYESYNVMAHCQERNWSYIIRIRDGNHSMKSGFNLPDTPCFDEAFDLNICRKQTNDMKELYRDFPNQYHFLPHNASFDFLLNSSRKSDPLQFYELHFRMVRLEIKPGFFETLVTNTDYSPEKLKELYAYRWGIETSFRDLKYSIGLTHFHAKKKEGILQEIYARFINFNVCKWLTSHVAIKTSKLKQTYKICFSDAVYACRKFLRNKLTSFQLETYIAKHLSIIRPNRTFQRKIKSKAPVSFTYRVT
>NC_017620.1|WP_002935598.1|1453873_1454920_-|hypothetical-protein
MKWLITHHVLNNIPIHVGQFTQIVGQNYELKYYIWQILIWYFGGKKYSEEDLILFNQEEPVISQDSEAIKRNAFKIISIAEVGDILEQISYKKGTIGFSYLSLKMQNIEIIEELEILNYHLHKIAQKVNSSISLINDEIEYEVGTTDLLPEQILTKQLTPHFKKSRDEIAIEFISNEKKLCFLLQMLNAIMQEQTKPILLVLKNLDDYLTYDSFVRIAQYLEELSNKYPYFNTILFPSQEGYLYLTEATLETVNIVSDRIEHYPAFTFLYTRYQQSYPSTSPLGEKEFLNSLRKISSYLFSSDINRVVSLADIDLVTLKIVNSLYQYDIKMVYMYKGISKLEENYLSS
>NC_017620.1|WP_002935599.1|1454916_1455240_-|CRISPR-associated-endonuclease-Cas2
MRYDAMRLLCFFDLPMETTQEKRQYRLFRKELIANGFEMLQFSVYYRTCPNRSFATKFYKKLQQSHLPAGNVRLLAVTEKQFSEMVLIVGGKTRQEEAISDRKLVII
>NC_017620.1|WP_002935600.1|1455236_1456151_-|type-II-CRISPR-associated-endonuclease-Cas1
MTWRIVHIHQSEKMRLKLDNLVIKKQGDEFTIPLSDISIIVAEGGDTVVTLRLLSALSKYNIALIVCDNHHLPTGIYHSQNGHFRAYKKLQAQLSWAPLQKDKLWQIIIYFKITNQQDVLAMQEKSLSTIQLLSDYREHIELGDRTNREGHAAKVYFNELFGKQFVRLTQQETDAVNAGLNYGYTIFRAQMARIIAGYGLNALIGIFHKNEYNQFNLADDLMEPFRQIVDVWVYMNLREADFLTYQHRLELTNLLNAKIRYGKENCSVTVAMDKFVKGFIRCIEDKDTNQFFCPVVSSLEMEKL
>NC_017620.1|WP_014637067.1|1456317_1459686_-|type-II-CRISPR-RNA-guided-endonuclease-Cas9
MSNGKILGLDIGIASVGVGVIDAQTGEIIHASSRIFPSANAANNAERRTFRGSRRLIRRKKHRIKRLDDLFNDFHINLDGEMSTDNPYVLRVKGLSQKLTVEELYISIKNIMKRRGISYLDDAESDNEAGRSDYAKAIERNRQLLTSKTPGEIQLERLEKYGQLRGNFTIIDEEGQSQQIINVFSTSDYVKEVEKILDCQKMYHKFISDEFCDKLIELLREKRKYYVGPGNEKSRTDYGIYRTDGTTLENLFGILIGKCTFYPDQYRSSRASYTAQEFNFLNDLNNLTVPTETKKLSQEQKEFLVNYAKETSVLGAGKILQQIAKLADCKVEDIRGYRLDNKDKPELHTFETYRAMKGLVPLVDIGVLSREQLDILADILTLNTDFEGIREALKKQLPNVFDEKQVKGLASFRKSKSQLFAKGWHNLSQKIMLEVIPELYATSDEQMTILTRLGKFEKSSVAEYPSSINVDEITDEIYNPVVAKSIRQTIKIINASIKKWDEFDQIVIEMPRDRNEDEEKKRIADGQKANAKEKADSILRAAELYCAGKVLPDYVYNGHNQLATKIRLWYQQGERCIYTGQPISIHDLIHNQNQYEIDHILPLSLTFDDSLSNKVLVLATANQEKAQRTPYNYLKSATSAWSYREFKDYVTKRKGIGKKKCEYLTFEEDINGFEVRSKFIQRNLVDTRYASKVILNALQDYFKISGIQTKVSVVRGQFTSQLRHKWGIEKTRETYHHHAVDALIIAASSQLRLWKKQESPLVVDYQEGRQVDLETGEILELTDEQYKELVYQPPYQGFVNTISSSAFDNEILFSYQVDSKVNRKISDATIYATRNAQLGKDKTEGIYVLGKIKDIYTQAGYEAFLKRYTKDKTSFLMYHKDLDTWEKVIEIILRDYREYDEKGKEIGNPFERYRRENGYVKKYSRKGNGTAIKSLKYYDNKLGNHIDITPENSRNAVVLQSLKPWRTDVYFNKETGKYEFLGIKYSDLSFEKGTGEYGISQEKYDSIKIAEGVAKKSIFKFTLYKQDLLFIKDIENNFGKLLRFTSKNDTSKHYVELKPYDKNKFGTEEPLLPVLGNVAKSGQCIKGLNKSNISIYKVRTDILGYRHFIKQEGEHPQLKFKK
>NC_017620.1|WP_002935608.1|1460369_1461743_+|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE
MITKEFDTITAISTPLGEGAIGIVRLSGTDAFAIASKVFKGKDLATVPSHSLNYGHIIDPATGQVLDEVILGVMRSPKTFTREDVIEINTHGGIAVTNEILQLLIRQGARMAEPGEFTKRAFLNGRVDLTQAEAVMDVIRAKTDKAMHNAVRQLDGSLSQLINDTRQEILNTLAQVEVNIDYPEYDDVEEATTELVREKTLQFQALLENLLRTARRGKILREGIATAIIGRPNVGKSSLLNNLLREEKAIVTDIAGTTRDVIEEYVNIKGVPLKLIDTAGIRETDDIVEKIGVERSKKALEEADLILLVLNASEPLTEQDRNLLAISDLANRIVLLNKTDLEEQIEADQLPEDVIRISVLKNQNIDQIEEKINQLFFENAGLVEQDATYLSNSRHISLIEQAVQSLQAVNDGLEMGMPVDLLQVDLTRCWQILGEITGDAAPDELITQLFSQFCLGK
>NC_017620.1|WP_002935611.1|1461854_1462931_+|hypothetical-protein
MKKLLICIVLLSCLVFPFIGWKLYAYQHNTITLTSEADFYLIYPGKVEAFQLNGQEPELLHTQKMNSEGYFGSGENYVIDSRYLVFANDQQKFINDNLISIDFNTGTVLRKPSQYSSYISGTDGQDFYTAGPYHILAQFDRNFDTIQTHVLNDDFIPNAPVMVDQTSVYLTGFVKDFTQEGPEENVLIVFDKKDFSKQEVFKYDNTIATGEGPWVNGTIYLPNLGKKTSEYTDIEQSSELLTFDTKTKTFSSVTLEHPSPSTLHALKDQKLLLIEHQNDMFSPISFTIYNTQTGQESYHRLDELNPRPYYIDHVRQLDGNRLLLILAGKALIYDWQAKKVLSQTILSENYVSGVWVND
>NC_017620.1|WP_009910392.1|1463052_1463361_-|hypothetical-protein
MKMFRNSKKSKLFIQKINELLSDSELKLSKALKFQLLEAMELCEKGSKISYLSYKIYPWVLEELALNRIQSDKLKMFKRYLEQERWKYYFGSALGMAFTSIR
>NC_017620.1|WP_002935618.1|1463449_1464913_-|flotillin-family-protein
MDFGFDILAIMIPIIVVVLFVLLFVFGYVSAKPNEAIVITGLGKPRTLIGRSGFMIPFIEKRSYISIEQFSTDVQTTDFVPTLDFINVKADAVVKVKVGISDELLNAAAQNFLNWKTADISASIQDVLEGNLREIIGQMELRDMVNNRQAFAEKVQSNAAPDLAKMGLEIIAFTVQSFTDDNDVIKNLGIDNIVTIQKDAANARAKAEREQAEVRAREDKAANDARVAADLEIAKKQNELAIEQANLKRQSDVQLAQANAAYGIEEQAQRKEIERATAEANIVKQQKEAEVKAEEVKVREQELSATIRKQAEAEKYARQQAAEADLIERQRKAEAELYETQREAEAQKARAEAAKYAAEQEAAGIEAKGRAEAEAIRLKLEAEAEGLSKKADAMAKFNDAAVTEMVVNVLPEIAKNIAAPLGNVDKITMYGEGNASKMVGDLMTTMDKTTEGLGLNVRDLISATLTGRAMSTGLLTAQETKEAEGDK
>NC_017620.1|WP_002935621.1|1464924_1465506_-|LemA-family-protein
MKKKWLAILLPILALLFLGMGAVGQYNGLVDSYAEVENAQANVDTQLQRRYDLIPNVVAAVKGAMEHEEEIFTAIAEARAKIGSSQVGTSDYNQAQSQLDSAVSRLLVVAENYPQLTANQQVSALITELEGTENRILVARKDYNSVATTYNKKIKRFPTSIYANLFGYEKVELFQATNDAATTVPSVDLSDKE

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Crispr_ID: NC_017620_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017620_2

1451376-1451609

TypeII

Consensus_repeat	Method
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	CRT
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	PILER-CR

3 spacers

csn2,cas2,cas1,cas9

The CRISPR arrays of NC_017620_2

>merge|NC_017620|2|1451376-1451609|CRT,PILER-CR
TGATTACGATAATATAAATCTTGAGAGTACAAAAACTACAAATGTTATGGGGATAACTACCAGAAGGTTTTACTGTTACTTAAATCTTGAGAGTACAAAAACTGGTGCTGTTGGCACTGGCTCAATTCGTGAGTTTTACTGTTACTTAAATCTTGAGAGTACAAAAACAGCAGGCAGATGTTGCTCAGATCGTCATTGGTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC

>NC_017620|2|1|1451376-1451609|CRT
TGATTACGATAATATAAATCTTGAGAGTACAAAAAC	TACAAATGTTATGGGGATAACTACCAGAAG
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	TGGTGCTGTTGGCACTGGCTCAATTCGTGA
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	AGCAGGCAGATGTTGCTCAGATCGTCATTG
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC

>NC_017620|2|2|1451442-1451609|PILER-CR
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	TGGTGCTGTTGGCACTGGCTCAATTCGTGA
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	AGCAGGCAGATGTTGCTCAGATCGTCATTG
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_017620.1\|WP_002935570.1\|1440557_1441298_-\|acyl-ACP-thioesterase	unknown	unknown	gnl\|CDD\|366738
NC_017620.1\|WP_002935608.1\|1460369_1461743_+\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE	unknown	unknown	gnl\|CDD\|235392
NC_017620.1\|WP_002935598.1\|1453873_1454920_-\|hypothetical-protein	csn2	cd12217_csn2_CAS-II-A	gnl\|CDD\|213410
NC_017620.1\|WP_002935583.1\|1445906_1446620_-\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|180275
NC_017620.1\|WP_002935569.1\|1439953_1440571_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|240029
NC_017620.1\|WP_002935587.1\|1447473_1447830_-\|ArsC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|239332
NC_017620.1\|WP_002935621.1\|1464924_1465506_-\|LemA-family-protein	unknown	unknown	gnl\|CDD\|377192
NC_017620.1\|WP_002935618.1\|1463449_1464913_-\|flotillin-family-protein	unknown	unknown	gnl\|CDD\|259798
NC_017620.1\|WP_009910385.1\|1443463_1445731_-\|glycogen/starch/alpha-glucan-family-phosphorylase	unknown	unknown	gnl\|CDD\|340853
NC_017620.1\|WP_002935597.1\|1449369_1450044_-\|ribose-5-phosphate-isomerase-RpiA	unknown	unknown	gnl\|CDD\|234816
NC_017620.1\|WP_014637067.1\|1456317_1459686_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	cd09643_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|273840
NC_017620.1\|WP_002935585.1\|1446652_1447462_-\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|236183
NC_017620.1\|WP_014637063.1\|1447829_1449041_-\|phosphopentomutase	unknown	unknown	gnl\|CDD\|235430
NC_017620.1\|WP_014637065.1\|1451756_1453046_-\|IS4-like-element-ISSsu2-family-transposase	unknown	unknown	gnl\|CDD\|376573
NC_017620.1\|WP_002935599.1\|1454916_1455240_-\|CRISPR-associated-endonuclease-Cas2	cas2	COG3512_cas2_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|226043
NC_017620.1\|WP_002935611.1\|1461854_1462931_+\|hypothetical-protein	unknown	unknown	unknown
NC_017620.1\|WP_002935571.1\|1441528_1442656_-\|oxygen-independent-coproporphyrinogen-III-oxidase	unknown	unknown	gnl\|CDD\|236309
NC_017620.1\|WP_002935572.1\|1442750_1443329_+\|teicoplanin-resistance-protein-VanZ	unknown	unknown	gnl\|CDD\|377417
NC_017620.1\|WP_002935600.1\|1455236_1456151_-\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|274694
NC_017620.1\|WP_009910392.1\|1463052_1463361_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_017620.1\|WP_002935570.1\|1440557_1441298_-\|acyl-ACP-thioesterase	gnl\|CDD\|366738	pfam01643, Acyl-ACP_TE, Acyl-ACP thioesterase. This family consists of various acyl-acyl carrier protein (ACP) thioesterases (TE) these terminate fatty acyl group extension via hydrolysing an acyl group on a fatty acid.	7.63063e-88
NC_017620.1\|WP_002935608.1\|1460369_1461743_+\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE	gnl\|CDD\|235392	PRK05291, trmE, tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE.	0
NC_017620.1\|WP_002935598.1\|1453873_1454920_-\|hypothetical-protein	gnl\|CDD\|213410	cd12217, Stu0660_Csn2, Stu0660-like CRISPR/Cas system-associated protein Csn2. Csn2 is a Nmeni subtype-specific Cas protein, which may function in the adaptation process which mediates the incorporation of foreign nucleic acids into the microbial host genome. Csn 2 may interact directly with double-stranded DNA. This family of Csn2 proteins includes Stu0660, the proteins are larger than other (canonical) Csn2 proteins as they have an additional alpha-helical C-terminal domain. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Csn2 has been predicted to be a functional analog of Cas4 based on anti-correlated phyletic patterns; also known as SPy1049 family.	2.6417e-137
NC_017620.1\|WP_002935583.1\|1445906_1446620_-\|purine-nucleoside-phosphorylase	gnl\|CDD\|180275	PRK05819, deoD, DeoD-type purine-nucleoside phosphorylase.	4.90632e-151
NC_017620.1\|WP_002935569.1\|1439953_1440571_-\|NUDIX-hydrolase	gnl\|CDD\|240029	cd04672, Nudix_Hydrolase_14, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	3.31442e-61
NC_017620.1\|WP_002935587.1\|1447473_1447830_-\|ArsC-family-transcriptional-regulator	gnl\|CDD\|239332	cd03034, ArsC_ArsC, Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the detoxification of arsenic, using reducing equivalents derived from glutathione (GSH) via glutaredoxin (GRX). ArsC contains a single catalytic cysteine, within a thioredoxin fold, that forms a covalent thiolate-As(V) intermediate, which is reduced by GRX through a mixed GSH-arsenate intermediate. This family of predominantly bacterial enzymes is unrelated to two other families of arsenate reductases which show similarity to low-molecular-weight acid phosphatases and phosphotyrosyl phosphatases.	1.02902e-20
NC_017620.1\|WP_002935618.1\|1463449_1464913_-\|flotillin-family-protein	gnl\|CDD\|259798	cd03399, SPFH_flotillin, Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily. The flotillin (reggie) like proteins are lipid raft-associated. Individual proteins of this SPFH family may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. In addition, microdomains formed from flotillin proteins may be dynamic units with their own regulatory functions. Flotillins have been implicated in signal transduction, vesicle trafficking, cytoskeleton rearrangement and interact with a variety of proteins. They may play a role in the progression of prion disease, in the pathogenesis of neurodegenerative diseases such as Parkinson's and Alzheimer's disease and in cancer invasion, and metastasis.	7.80101e-47
NC_017620.1\|WP_009910385.1\|1443463_1445731_-\|glycogen/starch/alpha-glucan-family-phosphorylase	gnl\|CDD\|340853	cd04300, GT35_Glycogen_Phosphorylase, glycogen phosphorylase and similar proteins. This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of oligosaccharides into glucose-1-phosphate units. They are important allosteric enzymes in carbohydrate metabolism. The allosteric control mechanisms of yeast and mammalian members of this family are different from that of bacterial members. The members of this family belong to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.	0
NC_017620.1\|WP_002935597.1\|1449369_1450044_-\|ribose-5-phosphate-isomerase-RpiA	gnl\|CDD\|234816	PRK00702, PRK00702, ribose-5-phosphate isomerase RpiA.	1.32327e-114
NC_017620.1\|WP_014637067.1\|1456317_1459686_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	gnl\|CDD\|273840	TIGR01865, conserved_hypothetical_protein, CRISPR subtype II/NMENI RNA-guided endonuclease Cas9/Csn1. CRISPR loci appear to be mobile elements with a wide host range. This model represents a protein found only in CRISPR-containing species, near other CRISPR-associated proteins (cas), as part of the NMENI subtype of CRISPR/Cas locus. The species range so far for this protein is animal pathogens and commensals only.	6.97095e-177
NC_017620.1\|WP_002935585.1\|1446652_1447462_-\|purine-nucleoside-phosphorylase	gnl\|CDD\|236183	PRK08202, PRK08202, purine nucleoside phosphorylase; Provisional.	6.03224e-162
NC_017620.1\|WP_014637063.1\|1447829_1449041_-\|phosphopentomutase	gnl\|CDD\|235430	PRK05362, PRK05362, phosphopentomutase; Provisional.	0
NC_017620.1\|WP_014637065.1\|1451756_1453046_-\|IS4-like-element-ISSsu2-family-transposase	gnl\|CDD\|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	3.58383e-08
NC_017620.1\|WP_002935599.1\|1454916_1455240_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	9.7745e-25
NC_017620.1\|WP_002935621.1\|1464924_1465506_-\|LemA-family-protein	gnl\|CDD\|377192	pfam04011, LemA, LemA family. The members of this family are related to the LemA protein. LemA contains an amino terminal predicted transmembrane helix. It has been predicted that the small amino terminus is extracellular. The exact molecular function of this protein is uncertain.	8.85941e-67
NC_017620.1\|WP_002935571.1\|1441528_1442656_-\|oxygen-independent-coproporphyrinogen-III-oxidase	gnl\|CDD\|236309	PRK08599, PRK08599, oxygen-independent coproporphyrinogen III oxidase.	0
NC_017620.1\|WP_002935572.1\|1442750_1443329_+\|teicoplanin-resistance-protein-VanZ	gnl\|CDD\|377417	pfam04892, VanZ, VanZ like family. This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.	9.00811e-06
NC_017620.1\|WP_002935600.1\|1455236_1456151_-\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274694	TIGR03639, cas1_NMENI, CRISPR-associated endonuclease Cas1, subtype II/NMENI. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is a prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 variant of the NMENI subtype of CRISPR/Cas system.	2.0775e-122

>NC_017620.1|WP_002935597.1|1449369_1450044_-|ribose-5-phosphate-isomerase-RpiA
MTNLKEQVGIKAAEFVTDGMIVGLGTGSTAYYFVQEIGRRVAEEGLQITGVTTSHATAEHAASLGIPLKNIDEVEYVDLTVDGADEVDGDFNGIKGGGAALLMEKVVAVNSKDCIWIVDESKVVQTLGAFKLPVEVVQYGAENLFRLFEKKGYRPSFRMRNGEKHITDMQNFIIDLDLRRIEDTYALAEELDRTVGVVEHGLFIGLISKVIVGTPEGPNIIEKK
>NC_017620.1|WP_014637063.1|1447829_1449041_-|phosphopentomutase
MPKFKRVHLVVMDSVGIGAAPDSDKFFNAGVADTESDTLGHISEKAGLEVPNMTKIGLGNIPRDTALATVPAESHPTGYVTKLEEVSLGKDTMTGHWEIMGLNITEPFDTFWDGFPEEILTKIEEFSGRKIIREANKPYSGTAVIDDFGPRQMETGELIVYTSADPVLQIAAHEDIIPLDELYRICEYARSITLERPALLGRIIARPYVGEPGNFSRTANRHDYAVSPFEETVLNKLADAGVPTYSVGKISDIFNGSGITNDMGHTKSNMHGVDVLIDTLKLSDFEEGFSFTNLVDFDAVYGHRRNIEGYRDCLQEFDARIPEIIDNMREDDLLLITADHGNDPSYAGTDHTREYVPLLAYSKVFKGSGVLPVGHFADISATVAENFGVDTAMIGESFLSQLV
>NC_017620.1|WP_002935587.1|1447473_1447830_-|ArsC-family-transcriptional-regulator
MEKLTVYYNPDCSKCKKLRILLPSQDMEVKWVNYLETPLRGAELTALLEKMGSQPSAVTRLKEEERLALPEEEIFERLVKEPALLNRPIIEREQTAFLCRPLEIIKEKMPEYDWSDYL
>NC_017620.1|WP_002935585.1|1446652_1447462_-|purine-nucleoside-phosphorylase
MSLLAKINETKTFLEEKGLVKPEFGLILGSGLGELAQEVENAIVIDYADIPNWGKSTVVGHAGKLVYGDLAGRKVLALQGRFHFYEGNPMEVVTFPVRVMKALGCEGVIVTNAAGGIGYGPGTLMAITDHINMTGQNPLIGENLEEFGPRFPDMSNAYTKEYREKAHAVAEKLGIKLDDGVYLGVTGPTYETPAEILAFKTMGAHAVGMSTVPEVIVAAHSGMKVLGISAITNFAAGFQSELNHEEVVEVTEQIKGNFKGLVKAILAEL
>NC_017620.1|WP_002935583.1|1445906_1446620_-|purine-nucleoside-phosphorylase
MSIHISAKPGEIADKILLPGDPLRAKFIAENFLEDAVCFNEVRNMFGYTGTYKGHRVSVMGTGMGMPSISIYAHELINEYGVKKLIRVGTAGSLNEDVHVRELVLAQAAATNSRMINIDWPEYDLPQIADFDLLDKAYHIAKELNMTTHVGNVLSSDSFYSPKLFSRNLELGQLGVKAVEMEAAALYYLGAKFGVQTLAIMTISDSLVNPEENTTAEERQNTFTDMMKVGLETLIAE
>NC_017620.1|WP_009910385.1|1443463_1445731_-|glycogen/starch/alpha-glucan-family-phosphorylase
MINLQNFVQSMYAKRIEDCTDQELYYALLAFTKQQSEAKYTNDQKKKVYYISAEFLIGKLLSNNLINLGLYDEVKSQLVAAGKDLIAIEDMELEPSLGNGGLGRLAACFLDSIASLGLNGDGVGLNYHFGLFRQLFEYHQQSAVPNEWITPRSWLTESPISYQVPFANFTLTSKLYDIDVPGYKMERKNRLRLFDLGSVDDNIIYDGIEFDKEDIFRNLTLFLYPDDSTDEGKVLRIFQQYFMVSNAAQLLIDEAVAKGSNLHDLPDYAVVQINDTHPSLVIPELIRLLELRGISFDEAVEIVKKMTAYTNHTILSEALEKWPLDFLNYVVPHLVPFIVELDRRAKEVKDDPAVNIIDEYGRVHMAHMDIHYGYSINGVAALHTEILKTSELKAFYELYPEKFNNKTNGITFRRWLMHANPSLASYLDGLLGHGYHHDASELEKLLDYKNDKELKSWLEKTKQHNKRKLQRHIAKTQGVHVNPESIFDVQIKRMHEYKRQQMNVLYVIHKYLDIKAGNIPTRPLTVFFGGKAAPAYTTAQDIIHLILVLSQVIKNDSEVAPHLQLVMIENYNVTEASFIIPAADISEQISLASKEASGTGNMKFMLNGALTIGTDDGANVEIHELVGDENIYIFGQDSQTVIEHYANRTYHPYSFYEREVIRPLIDFITSDTIRHAGGIDERLWRLQDNLKHNDHFMTLLDLEDYIVTKERMLADYEDRDSWLEKVIVNIAKAGFFSSDRTIQQYNEDIWHLEAK
>NC_017620.1|WP_002935572.1|1442750_1443329_+|teicoplanin-resistance-protein-VanZ
MKKEIIYDCINLILSFLLCRWLFMTFLFYQFSNIFMTIDFWPTLAAILLMTGFCFTLFRLVYKPHISRLTLWFFYACYGLLLVYLLFFKSMGVRGVNWNLLSTFSQDLFLNPTILVFNLLLFLPLGLLFSFSWKKLSLFVGAILLVEACQFFFSLGFFDLGDILLNTSGFALGNFLGQSAIAQSFKNRIQKK
>NC_017620.1|WP_002935571.1|1441528_1442656_-|oxygen-independent-coproporphyrinogen-III-oxidase
MKKRPTSAYIHIPFCTQICYYCDFSKVFIKNQPVDEYLAALMEEVKFYDLPALRTLYIGGGTPSALSADQLDYLLTNLEDLLDLSQLEEFTIEANPGDLTADKIAVLKKSKCNRVSLGVQTFDDRMLKKIGRSHNQAQIYETIATLKEAGFYNISIDLIYALPGQTMEQVVDNVAKALELDIPHMSLYSLILENHTVFMNRQRRGNLHLPNEDVESDMFDYILQELEKNGFEHYEISNFTKPGFESRHNLMYWDNSEYYGLGAGASGYIDGMRYRNRGPIQHYLKSIREKGHSRLHEEFLSQTEQMEEEMFLGLRKKTGVSIERFEEKFGISFEDRYGQVVRDLKNEGLLQEEDRWLRMTKKGLFLGDTVAERFI
>NC_017620.1|WP_002935570.1|1440557_1441298_-|acyl-ACP-thioesterase
MGLTYQEEFTIPFDMVDVKQEIKLPDFISYCLGVSGRQSEELGRSDLYVFQEFGLIWVVTDYELTIQRLPKYNETITIKTEAVAYNKFFCHRMFYIYDAAGNLLLDILCYFVLIDFETRKVAPVPEDLIAPYQSEQVKKLPRAPKYQLLENPSVQEFPVRYFDLDMNGHVNNGKYLEWMYEALGYDFLLCHVPKKIQLKYLKEVEATSLVSSRMVAEAGGSQHEIVVDGHIHAQAVIEWRERHVAG
>NC_017620.1|WP_002935569.1|1439953_1440571_-|NUDIX-hydrolase
MSQDKWLEWAVRLQALAQTGLAYGKDVYDMERFEEIRQIAAEMLVEPSGQPLEVVKDLFCNETGYQTPKLDTRAAIFQEDKILLVQENDGLWSLPGGWCDVDQSVKDNVVKEVKEEAGLDVEAQRVVAILDKHKNNPAKSAHRVTKVFILCRLLGGEFQPNSETVASGFFSLDDLPPLYLGKNTAEQLALCLEASRSEHWETRFD
>NC_017620.1|WP_014637065.1|1451756_1453046_-|IS4-like-element-ISSsu2-family-transposase
MLDQIKAHLLDSINDIVSSANQFVLHPEKDFSRQSQLTMKTMIQAILTMGGNTLAKELLDLDLPVSQSAFVQRRYQIKHQAFKTLFRDITSKIPISDNLPILAVDGSDMILPRNRFDKTTSFQTGPHHTPYNLIHINALYNLEQEIYHDLRIQDNREVDERAAFIDMMKTSSFKQALVIMDRGYESYNVMAHCQERNWSYIIRIRDGNHSMKSGFNLPDTPCFDEAFDLNICRKQTNDMKELYRDFPNQYHFLPHNASFDFLLNSSRKSDPLQFYELHFRMVRLEIKPGFFETLVTNTDYSPEKLKELYAYRWGIETSFRDLKYSIGLTHFHAKKKEGILQEIYARFINFNVCKWLTSHVAIKTSKLKQTYKICFSDAVYACRKFLRNKLTSFQLETYIAKHLSIIRPNRTFQRKIKSKAPVSFTYRVT
>NC_017620.1|WP_002935598.1|1453873_1454920_-|hypothetical-protein
MKWLITHHVLNNIPIHVGQFTQIVGQNYELKYYIWQILIWYFGGKKYSEEDLILFNQEEPVISQDSEAIKRNAFKIISIAEVGDILEQISYKKGTIGFSYLSLKMQNIEIIEELEILNYHLHKIAQKVNSSISLINDEIEYEVGTTDLLPEQILTKQLTPHFKKSRDEIAIEFISNEKKLCFLLQMLNAIMQEQTKPILLVLKNLDDYLTYDSFVRIAQYLEELSNKYPYFNTILFPSQEGYLYLTEATLETVNIVSDRIEHYPAFTFLYTRYQQSYPSTSPLGEKEFLNSLRKISSYLFSSDINRVVSLADIDLVTLKIVNSLYQYDIKMVYMYKGISKLEENYLSS
>NC_017620.1|WP_002935599.1|1454916_1455240_-|CRISPR-associated-endonuclease-Cas2
MRYDAMRLLCFFDLPMETTQEKRQYRLFRKELIANGFEMLQFSVYYRTCPNRSFATKFYKKLQQSHLPAGNVRLLAVTEKQFSEMVLIVGGKTRQEEAISDRKLVII
>NC_017620.1|WP_002935600.1|1455236_1456151_-|type-II-CRISPR-associated-endonuclease-Cas1
MTWRIVHIHQSEKMRLKLDNLVIKKQGDEFTIPLSDISIIVAEGGDTVVTLRLLSALSKYNIALIVCDNHHLPTGIYHSQNGHFRAYKKLQAQLSWAPLQKDKLWQIIIYFKITNQQDVLAMQEKSLSTIQLLSDYREHIELGDRTNREGHAAKVYFNELFGKQFVRLTQQETDAVNAGLNYGYTIFRAQMARIIAGYGLNALIGIFHKNEYNQFNLADDLMEPFRQIVDVWVYMNLREADFLTYQHRLELTNLLNAKIRYGKENCSVTVAMDKFVKGFIRCIEDKDTNQFFCPVVSSLEMEKL
>NC_017620.1|WP_014637067.1|1456317_1459686_-|type-II-CRISPR-RNA-guided-endonuclease-Cas9
MSNGKILGLDIGIASVGVGVIDAQTGEIIHASSRIFPSANAANNAERRTFRGSRRLIRRKKHRIKRLDDLFNDFHINLDGEMSTDNPYVLRVKGLSQKLTVEELYISIKNIMKRRGISYLDDAESDNEAGRSDYAKAIERNRQLLTSKTPGEIQLERLEKYGQLRGNFTIIDEEGQSQQIINVFSTSDYVKEVEKILDCQKMYHKFISDEFCDKLIELLREKRKYYVGPGNEKSRTDYGIYRTDGTTLENLFGILIGKCTFYPDQYRSSRASYTAQEFNFLNDLNNLTVPTETKKLSQEQKEFLVNYAKETSVLGAGKILQQIAKLADCKVEDIRGYRLDNKDKPELHTFETYRAMKGLVPLVDIGVLSREQLDILADILTLNTDFEGIREALKKQLPNVFDEKQVKGLASFRKSKSQLFAKGWHNLSQKIMLEVIPELYATSDEQMTILTRLGKFEKSSVAEYPSSINVDEITDEIYNPVVAKSIRQTIKIINASIKKWDEFDQIVIEMPRDRNEDEEKKRIADGQKANAKEKADSILRAAELYCAGKVLPDYVYNGHNQLATKIRLWYQQGERCIYTGQPISIHDLIHNQNQYEIDHILPLSLTFDDSLSNKVLVLATANQEKAQRTPYNYLKSATSAWSYREFKDYVTKRKGIGKKKCEYLTFEEDINGFEVRSKFIQRNLVDTRYASKVILNALQDYFKISGIQTKVSVVRGQFTSQLRHKWGIEKTRETYHHHAVDALIIAASSQLRLWKKQESPLVVDYQEGRQVDLETGEILELTDEQYKELVYQPPYQGFVNTISSSAFDNEILFSYQVDSKVNRKISDATIYATRNAQLGKDKTEGIYVLGKIKDIYTQAGYEAFLKRYTKDKTSFLMYHKDLDTWEKVIEIILRDYREYDEKGKEIGNPFERYRRENGYVKKYSRKGNGTAIKSLKYYDNKLGNHIDITPENSRNAVVLQSLKPWRTDVYFNKETGKYEFLGIKYSDLSFEKGTGEYGISQEKYDSIKIAEGVAKKSIFKFTLYKQDLLFIKDIENNFGKLLRFTSKNDTSKHYVELKPYDKNKFGTEEPLLPVLGNVAKSGQCIKGLNKSNISIYKVRTDILGYRHFIKQEGEHPQLKFKK
>NC_017620.1|WP_002935608.1|1460369_1461743_+|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE
MITKEFDTITAISTPLGEGAIGIVRLSGTDAFAIASKVFKGKDLATVPSHSLNYGHIIDPATGQVLDEVILGVMRSPKTFTREDVIEINTHGGIAVTNEILQLLIRQGARMAEPGEFTKRAFLNGRVDLTQAEAVMDVIRAKTDKAMHNAVRQLDGSLSQLINDTRQEILNTLAQVEVNIDYPEYDDVEEATTELVREKTLQFQALLENLLRTARRGKILREGIATAIIGRPNVGKSSLLNNLLREEKAIVTDIAGTTRDVIEEYVNIKGVPLKLIDTAGIRETDDIVEKIGVERSKKALEEADLILLVLNASEPLTEQDRNLLAISDLANRIVLLNKTDLEEQIEADQLPEDVIRISVLKNQNIDQIEEKINQLFFENAGLVEQDATYLSNSRHISLIEQAVQSLQAVNDGLEMGMPVDLLQVDLTRCWQILGEITGDAAPDELITQLFSQFCLGK
>NC_017620.1|WP_002935611.1|1461854_1462931_+|hypothetical-protein
MKKLLICIVLLSCLVFPFIGWKLYAYQHNTITLTSEADFYLIYPGKVEAFQLNGQEPELLHTQKMNSEGYFGSGENYVIDSRYLVFANDQQKFINDNLISIDFNTGTVLRKPSQYSSYISGTDGQDFYTAGPYHILAQFDRNFDTIQTHVLNDDFIPNAPVMVDQTSVYLTGFVKDFTQEGPEENVLIVFDKKDFSKQEVFKYDNTIATGEGPWVNGTIYLPNLGKKTSEYTDIEQSSELLTFDTKTKTFSSVTLEHPSPSTLHALKDQKLLLIEHQNDMFSPISFTIYNTQTGQESYHRLDELNPRPYYIDHVRQLDGNRLLLILAGKALIYDWQAKKVLSQTILSENYVSGVWVND
>NC_017620.1|WP_009910392.1|1463052_1463361_-|hypothetical-protein
MKMFRNSKKSKLFIQKINELLSDSELKLSKALKFQLLEAMELCEKGSKISYLSYKIYPWVLEELALNRIQSDKLKMFKRYLEQERWKYYFGSALGMAFTSIR
>NC_017620.1|WP_002935618.1|1463449_1464913_-|flotillin-family-protein
MDFGFDILAIMIPIIVVVLFVLLFVFGYVSAKPNEAIVITGLGKPRTLIGRSGFMIPFIEKRSYISIEQFSTDVQTTDFVPTLDFINVKADAVVKVKVGISDELLNAAAQNFLNWKTADISASIQDVLEGNLREIIGQMELRDMVNNRQAFAEKVQSNAAPDLAKMGLEIIAFTVQSFTDDNDVIKNLGIDNIVTIQKDAANARAKAEREQAEVRAREDKAANDARVAADLEIAKKQNELAIEQANLKRQSDVQLAQANAAYGIEEQAQRKEIERATAEANIVKQQKEAEVKAEEVKVREQELSATIRKQAEAEKYARQQAAEADLIERQRKAEAELYETQREAEAQKARAEAAKYAAEQEAAGIEAKGRAEAEAIRLKLEAEAEGLSKKADAMAKFNDAAVTEMVVNVLPEIAKNIAAPLGNVDKITMYGEGNASKMVGDLMTTMDKTTEGLGLNVRDLISATLTGRAMSTGLLTAQETKEAEGDK
>NC_017620.1|WP_002935621.1|1464924_1465506_-|LemA-family-protein
MKKKWLAILLPILALLFLGMGAVGQYNGLVDSYAEVENAQANVDTQLQRRYDLIPNVVAAVKGAMEHEEEIFTAIAEARAKIGSSQVGTSDYNQAQSQLDSAVSRLLVVAENYPQLTANQQVSALITELEGTENRILVARKDYNSVATTYNKKIKRFPTSIYANLFGYEKVELFQATNDAATTVPSVDLSDKE

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Identity
NC_017620_1	1.1\|1450251\|27\|NC_017620\|PILER-CR	1450251-1450277	27	NC_017620.1	1450627-1450653	1.0
NC_017620_1	1.1\|1450251\|27\|NC_017620\|PILER-CR	1450251-1450277	27	NC_017620.1	1450693-1450719	1.0
NC_017620_1	1.1\|1450251\|27\|NC_017620\|PILER-CR	1450251-1450277	27	NC_017620.1	1450759-1450785	1.0
NC_017620_1	1.1\|1450251\|27\|NC_017620\|PILER-CR	1450251-1450277	27	NC_017620.1	1450825-1450851	1.0
NC_017620_1	1.1\|1450251\|27\|NC_017620\|PILER-CR	1450251-1450277	27	NC_017620.1	1450891-1450917	1.0
NC_017620_1	1.1\|1450251\|27\|NC_017620\|PILER-CR	1450251-1450277	27	NC_017620.1	1450957-1450983	1.0
NC_017620_1	1.2\|1450317\|27\|NC_017620\|PILER-CR	1450317-1450343	27	NC_017620.1	1450627-1450653	1.0
NC_017620_1	1.2\|1450317\|27\|NC_017620\|PILER-CR	1450317-1450343	27	NC_017620.1	1450693-1450719	1.0
NC_017620_1	1.2\|1450317\|27\|NC_017620\|PILER-CR	1450317-1450343	27	NC_017620.1	1450759-1450785	1.0
NC_017620_1	1.2\|1450317\|27\|NC_017620\|PILER-CR	1450317-1450343	27	NC_017620.1	1450825-1450851	1.0
NC_017620_1	1.2\|1450317\|27\|NC_017620\|PILER-CR	1450317-1450343	27	NC_017620.1	1450891-1450917	1.0
NC_017620_1	1.2\|1450317\|27\|NC_017620\|PILER-CR	1450317-1450343	27	NC_017620.1	1450957-1450983	1.0
NC_017620_1	1.3\|1450383\|27\|NC_017620\|PILER-CR	1450383-1450409	27	NC_017620.1	1450627-1450653	1.0
NC_017620_1	1.3\|1450383\|27\|NC_017620\|PILER-CR	1450383-1450409	27	NC_017620.1	1450693-1450719	1.0
NC_017620_1	1.3\|1450383\|27\|NC_017620\|PILER-CR	1450383-1450409	27	NC_017620.1	1450759-1450785	1.0
NC_017620_1	1.3\|1450383\|27\|NC_017620\|PILER-CR	1450383-1450409	27	NC_017620.1	1450825-1450851	1.0
NC_017620_1	1.3\|1450383\|27\|NC_017620\|PILER-CR	1450383-1450409	27	NC_017620.1	1450891-1450917	1.0
NC_017620_1	1.3\|1450383\|27\|NC_017620\|PILER-CR	1450383-1450409	27	NC_017620.1	1450957-1450983	1.0
NC_017620_1	1.4\|1450449\|27\|NC_017620\|PILER-CR	1450449-1450475	27	NC_017620.1	1450627-1450653	1.0
NC_017620_1	1.4\|1450449\|27\|NC_017620\|PILER-CR	1450449-1450475	27	NC_017620.1	1450693-1450719	1.0
NC_017620_1	1.4\|1450449\|27\|NC_017620\|PILER-CR	1450449-1450475	27	NC_017620.1	1450759-1450785	1.0
NC_017620_1	1.4\|1450449\|27\|NC_017620\|PILER-CR	1450449-1450475	27	NC_017620.1	1450825-1450851	1.0
NC_017620_1	1.4\|1450449\|27\|NC_017620\|PILER-CR	1450449-1450475	27	NC_017620.1	1450891-1450917	1.0
NC_017620_1	1.4\|1450449\|27\|NC_017620\|PILER-CR	1450449-1450475	27	NC_017620.1	1450957-1450983	1.0
NC_017620_1	1.5\|1450515\|27\|NC_017620\|PILER-CR	1450515-1450541	27	NC_017620.1	1450627-1450653	1.0
NC_017620_1	1.5\|1450515\|27\|NC_017620\|PILER-CR	1450515-1450541	27	NC_017620.1	1450693-1450719	1.0
NC_017620_1	1.5\|1450515\|27\|NC_017620\|PILER-CR	1450515-1450541	27	NC_017620.1	1450759-1450785	1.0
NC_017620_1	1.5\|1450515\|27\|NC_017620\|PILER-CR	1450515-1450541	27	NC_017620.1	1450825-1450851	1.0
NC_017620_1	1.5\|1450515\|27\|NC_017620\|PILER-CR	1450515-1450541	27	NC_017620.1	1450891-1450917	1.0
NC_017620_1	1.5\|1450515\|27\|NC_017620\|PILER-CR	1450515-1450541	27	NC_017620.1	1450957-1450983	1.0
NC_017620_2	2.1\|1451412\|30\|NC_017620\|CRT	1451412-1451441	30	NC_017620.1	1450182-1450211	1.0

1. spacer 1.1|1450251|27|NC_017620|PILER-CR matches to position: 1450627-1450653, mismatch: 0, identity: 1.0

gaatattctcagcaagtaaacactgat	CRISPR spacer
gaatattctcagcaagtaaacactgat	Protospacer
***************************

2. spacer 1.1|1450251|27|NC_017620|PILER-CR matches to position: 1450693-1450719, mismatch: 0, identity: 1.0

gaatattctcagcaagtaaacactgat	CRISPR spacer
gaatattctcagcaagtaaacactgat	Protospacer
***************************

3. spacer 1.1|1450251|27|NC_017620|PILER-CR matches to position: 1450759-1450785, mismatch: 0, identity: 1.0

gaatattctcagcaagtaaacactgat	CRISPR spacer
gaatattctcagcaagtaaacactgat	Protospacer
***************************

4. spacer 1.1|1450251|27|NC_017620|PILER-CR matches to position: 1450825-1450851, mismatch: 0, identity: 1.0

gaatattctcagcaagtaaacactgat	CRISPR spacer
gaatattctcagcaagtaaacactgat	Protospacer
***************************

5. spacer 1.1|1450251|27|NC_017620|PILER-CR matches to position: 1450891-1450917, mismatch: 0, identity: 1.0

gaatattctcagcaagtaaacactgat	CRISPR spacer
gaatattctcagcaagtaaacactgat	Protospacer
***************************

6. spacer 1.1|1450251|27|NC_017620|PILER-CR matches to position: 1450957-1450983, mismatch: 0, identity: 1.0

gaatattctcagcaagtaaacactgat	CRISPR spacer
gaatattctcagcaagtaaacactgat	Protospacer
***************************

7. spacer 1.2|1450317|27|NC_017620|PILER-CR matches to position: 1450627-1450653, mismatch: 0, identity: 1.0

gaatattctcagcaagtaaacactgat	CRISPR spacer
gaatattctcagcaagtaaacactgat	Protospacer
***************************

8. spacer 1.2|1450317|27|NC_017620|PILER-CR matches to position: 1450693-1450719, mismatch: 0, identity: 1.0

gaatattctcagcaagtaaacactgat	CRISPR spacer
gaatattctcagcaagtaaacactgat	Protospacer
***************************

9. spacer 1.2|1450317|27|NC_017620|PILER-CR matches to position: 1450759-1450785, mismatch: 0, identity: 1.0

gaatattctcagcaagtaaacactgat	CRISPR spacer
gaatattctcagcaagtaaacactgat	Protospacer
***************************

10. spacer 1.2|1450317|27|NC_017620|PILER-CR matches to position: 1450825-1450851, mismatch: 0, identity: 1.0

gaatattctcagcaagtaaacactgat	CRISPR spacer
gaatattctcagcaagtaaacactgat	Protospacer
***************************

11. spacer 1.2|1450317|27|NC_017620|PILER-CR matches to position: 1450891-1450917, mismatch: 0, identity: 1.0

gaatattctcagcaagtaaacactgat	CRISPR spacer
gaatattctcagcaagtaaacactgat	Protospacer
***************************

12. spacer 1.2|1450317|27|NC_017620|PILER-CR matches to position: 1450957-1450983, mismatch: 0, identity: 1.0

gaatattctcagcaagtaaacactgat	CRISPR spacer
gaatattctcagcaagtaaacactgat	Protospacer
***************************

13. spacer 1.3|1450383|27|NC_017620|PILER-CR matches to position: 1450627-1450653, mismatch: 0, identity: 1.0

gaatattctcagcaagtaaacactgat	CRISPR spacer
gaatattctcagcaagtaaacactgat	Protospacer
***************************

14. spacer 1.3|1450383|27|NC_017620|PILER-CR matches to position: 1450693-1450719, mismatch: 0, identity: 1.0

gaatattctcagcaagtaaacactgat	CRISPR spacer
gaatattctcagcaagtaaacactgat	Protospacer
***************************

15. spacer 1.3|1450383|27|NC_017620|PILER-CR matches to position: 1450759-1450785, mismatch: 0, identity: 1.0

gaatattctcagcaagtaaacactgat	CRISPR spacer
gaatattctcagcaagtaaacactgat	Protospacer
***************************

16. spacer 1.3|1450383|27|NC_017620|PILER-CR matches to position: 1450825-1450851, mismatch: 0, identity: 1.0

gaatattctcagcaagtaaacactgat	CRISPR spacer
gaatattctcagcaagtaaacactgat	Protospacer
***************************

17. spacer 1.3|1450383|27|NC_017620|PILER-CR matches to position: 1450891-1450917, mismatch: 0, identity: 1.0

gaatattctcagcaagtaaacactgat	CRISPR spacer
gaatattctcagcaagtaaacactgat	Protospacer
***************************

18. spacer 1.3|1450383|27|NC_017620|PILER-CR matches to position: 1450957-1450983, mismatch: 0, identity: 1.0

gaatattctcagcaagtaaacactgat	CRISPR spacer
gaatattctcagcaagtaaacactgat	Protospacer
***************************

19. spacer 1.4|1450449|27|NC_017620|PILER-CR matches to position: 1450627-1450653, mismatch: 0, identity: 1.0

gaatattctcagcaagtaaacactgat	CRISPR spacer
gaatattctcagcaagtaaacactgat	Protospacer
***************************

20. spacer 1.4|1450449|27|NC_017620|PILER-CR matches to position: 1450693-1450719, mismatch: 0, identity: 1.0

gaatattctcagcaagtaaacactgat	CRISPR spacer
gaatattctcagcaagtaaacactgat	Protospacer
***************************

21. spacer 1.4|1450449|27|NC_017620|PILER-CR matches to position: 1450759-1450785, mismatch: 0, identity: 1.0

gaatattctcagcaagtaaacactgat	CRISPR spacer
gaatattctcagcaagtaaacactgat	Protospacer
***************************

22. spacer 1.4|1450449|27|NC_017620|PILER-CR matches to position: 1450825-1450851, mismatch: 0, identity: 1.0

gaatattctcagcaagtaaacactgat	CRISPR spacer
gaatattctcagcaagtaaacactgat	Protospacer
***************************

23. spacer 1.4|1450449|27|NC_017620|PILER-CR matches to position: 1450891-1450917, mismatch: 0, identity: 1.0

gaatattctcagcaagtaaacactgat	CRISPR spacer
gaatattctcagcaagtaaacactgat	Protospacer
***************************

24. spacer 1.4|1450449|27|NC_017620|PILER-CR matches to position: 1450957-1450983, mismatch: 0, identity: 1.0

gaatattctcagcaagtaaacactgat	CRISPR spacer
gaatattctcagcaagtaaacactgat	Protospacer
***************************

25. spacer 1.5|1450515|27|NC_017620|PILER-CR matches to position: 1450627-1450653, mismatch: 0, identity: 1.0

gaatattctcagcaagtaaacactgat	CRISPR spacer
gaatattctcagcaagtaaacactgat	Protospacer
***************************

26. spacer 1.5|1450515|27|NC_017620|PILER-CR matches to position: 1450693-1450719, mismatch: 0, identity: 1.0

gaatattctcagcaagtaaacactgat	CRISPR spacer
gaatattctcagcaagtaaacactgat	Protospacer
***************************

27. spacer 1.5|1450515|27|NC_017620|PILER-CR matches to position: 1450759-1450785, mismatch: 0, identity: 1.0

gaatattctcagcaagtaaacactgat	CRISPR spacer
gaatattctcagcaagtaaacactgat	Protospacer
***************************

28. spacer 1.5|1450515|27|NC_017620|PILER-CR matches to position: 1450825-1450851, mismatch: 0, identity: 1.0

gaatattctcagcaagtaaacactgat	CRISPR spacer
gaatattctcagcaagtaaacactgat	Protospacer
***************************

29. spacer 1.5|1450515|27|NC_017620|PILER-CR matches to position: 1450891-1450917, mismatch: 0, identity: 1.0

gaatattctcagcaagtaaacactgat	CRISPR spacer
gaatattctcagcaagtaaacactgat	Protospacer
***************************

30. spacer 1.5|1450515|27|NC_017620|PILER-CR matches to position: 1450957-1450983, mismatch: 0, identity: 1.0

gaatattctcagcaagtaaacactgat	CRISPR spacer
gaatattctcagcaagtaaacactgat	Protospacer
***************************

31. spacer 2.1|1451412|30|NC_017620|CRT matches to position: 1450182-1450211, mismatch: 0, identity: 1.0

tacaaatgttatggggataactaccagaag	CRISPR spacer
tacaaatgttatggggataactaccagaag	Protospacer
******************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_017620_2	2.3\|1451544\|30\|NC_017620\|CRT,PILER-CR	1451544-1451573	30	KC348600	Streptococcus phage phi5218, complete genome	18856-18885	3	0.9
NC_017620_2	2.1\|1451412\|30\|NC_017620\|CRT	1451412-1451441	30	AJ609634	Bacteriophage EJ-1 proviral DNA, complete genome	6909-6938	7	0.767
NC_017620_2	2.1\|1451412\|30\|NC_017620\|CRT	1451412-1451441	30	NC_005294	Streptococcus prophage EJ-1, complete genome	6909-6938	7	0.767
NC_017620_2	2.1\|1451412\|30\|NC_017620\|CRT	1451412-1451441	30	KY065449	Streptococcus phage IPP5, complete genome	7026-7055	7	0.767
NC_017620_2	2.3\|1451544\|30\|NC_017620\|CRT,PILER-CR	1451544-1451573	30	MK295205	Shigella phage vB_SflM_004, complete genome	60968-60997	8	0.733
NC_017620_2	2.3\|1451544\|30\|NC_017620\|CRT,PILER-CR	1451544-1451573	30	NC_028247	Citrobacter phage Michonne, complete genome	39168-39197	8	0.733
NC_017620_2	2.3\|1451544\|30\|NC_017620\|CRT,PILER-CR	1451544-1451573	30	KM236239	Citrobacter phage Moogle, complete genome	40923-40952	8	0.733
NC_017620_2	2.3\|1451544\|30\|NC_017620\|CRT,PILER-CR	1451544-1451573	30	MH920362	Citrobacter phage Maleficent, complete genome	39204-39233	8	0.733
NC_017620_2	2.3\|1451544\|30\|NC_017620\|CRT,PILER-CR	1451544-1451573	30	KY654690	Citrobacter phage Mijalis, complete genome	40923-40952	8	0.733
NC_017620_2	2.3\|1451544\|30\|NC_017620\|CRT,PILER-CR	1451544-1451573	30	NC_019690	Pseudanabaena sp. PCC 7367 plasmid pPSE7367.01, complete sequence	266471-266500	8	0.733
NC_017620_2	2.3\|1451544\|30\|NC_017620\|CRT,PILER-CR	1451544-1451573	30	NC_041977	Citrobacter phage Mordin, complete genome	52342-52371	8	0.733

1. spacer 2.3|1451544|30|NC_017620|CRT,PILER-CR matches to KC348600 (Streptococcus phage phi5218, complete genome) position: , mismatch: 3, identity: 0.9

agcaggcagatgttgctcagatcgtcattg	CRISPR spacer
aacaggcagatgtggctcaaatcgtcattg	Protospacer
*.*********** *****.**********

2. spacer 2.1|1451412|30|NC_017620|CRT matches to AJ609634 (Bacteriophage EJ-1 proviral DNA, complete genome) position: , mismatch: 7, identity: 0.767

tacaaatgttatggggataactaccagaag	CRISPR spacer
taaaaatgttaaggggataactaaagaaac	Protospacer
** ******** ***********  ..**

3. spacer 2.1|1451412|30|NC_017620|CRT matches to NC_005294 (Streptococcus prophage EJ-1, complete genome) position: , mismatch: 7, identity: 0.767

tacaaatgttatggggataactaccagaag	CRISPR spacer
taaaaatgttaaggggataactaaagaaac	Protospacer
** ******** ***********  ..**

4. spacer 2.1|1451412|30|NC_017620|CRT matches to KY065449 (Streptococcus phage IPP5, complete genome) position: , mismatch: 7, identity: 0.767

tacaaatgttatggggataactaccagaag	CRISPR spacer
taaaaatgttaaggggataactaaagaaac	Protospacer
** ******** ***********  ..**

5. spacer 2.3|1451544|30|NC_017620|CRT,PILER-CR matches to MK295205 (Shigella phage vB_SflM_004, complete genome) position: , mismatch: 8, identity: 0.733

agcaggcagatgttgctcagatcgtcattg	CRISPR spacer
ttatggcagaagttgctcaaatcgtcaaag	Protospacer
    ****** ********.*******  *

6. spacer 2.3|1451544|30|NC_017620|CRT,PILER-CR matches to NC_028247 (Citrobacter phage Michonne, complete genome) position: , mismatch: 8, identity: 0.733

agcaggcagatgttgctcagatcgtcattg	CRISPR spacer
ttatggcagaagttgctcaaatcgtcaaag	Protospacer
    ****** ********.*******  *

7. spacer 2.3|1451544|30|NC_017620|CRT,PILER-CR matches to KM236239 (Citrobacter phage Moogle, complete genome) position: , mismatch: 8, identity: 0.733

agcaggcagatgttgctcagatcgtcattg	CRISPR spacer
ttatggcagaagttgctcaaatcgtcaaag	Protospacer
    ****** ********.*******  *

8. spacer 2.3|1451544|30|NC_017620|CRT,PILER-CR matches to MH920362 (Citrobacter phage Maleficent, complete genome) position: , mismatch: 8, identity: 0.733

agcaggcagatgttgctcagatcgtcattg	CRISPR spacer
ttatggcagaagttgctcaaatcgtcaaag	Protospacer
    ****** ********.*******  *

9. spacer 2.3|1451544|30|NC_017620|CRT,PILER-CR matches to KY654690 (Citrobacter phage Mijalis, complete genome) position: , mismatch: 8, identity: 0.733

agcaggcagatgttgctcagatcgtcattg	CRISPR spacer
ttatggcagaagttgctcaaatcgtcaaag	Protospacer
    ****** ********.*******  *

10. spacer 2.3|1451544|30|NC_017620|CRT,PILER-CR matches to NC_019690 (Pseudanabaena sp. PCC 7367 plasmid pPSE7367.01, complete sequence) position: , mismatch: 8, identity: 0.733

agcaggcagatgttgctcagatcgtcattg	CRISPR spacer
cgcaggcagacggtgctcagatcgcgcata	Protospacer
 *********.* ***********.   *.

11. spacer 2.3|1451544|30|NC_017620|CRT,PILER-CR matches to NC_041977 (Citrobacter phage Mordin, complete genome) position: , mismatch: 8, identity: 0.733

agcaggcagatgttgctcagatcgtcattg	CRISPR spacer
ttatggcagaagttgctcaaatcgtcaaag	Protospacer
    ****** ********.*******  *

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

31777 : 41837

Synechococcus_phage(28.57%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014636740.1\|31777_35497_+	phosphoribosylformylglycinamidine synthase	A6N228	Microbacterium_phage	1.0e-39	26.4
WP_002935326.1\|35499_36954_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	7.2e-58	35.4
WP_009908859.1\|37009_38032_+	phosphoribosylformylglycinamidine cyclo-ligase	A0A0E3FGG1	Synechococcus_phage	3.0e-58	41.1
WP_009908860.1\|38028_38580_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	2.1e-26	38.5
WP_002935323.1\|38589_40137_+	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	Q58MG4	Prochlorococcus_phage	8.5e-73	47.0
WP_002935322.1\|40201_41032_+	DNA adenine methylase	A0A1S5PRR3	Streptococcus_phage	7.7e-89	59.3
WP_032499218.1\|41021_41837_+	site-specific DNA-methyltransferase	A0A1W6JJW1	Lactococcus_phage	1.1e-26	33.5

DBSCAN-SWA_2

324435 : 394009

Streptococcus_phage(22.22%)

tRNA,holin,transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002937468.1\|324435_325185_+\|tRNA	tRNA pseudouridine(38-40) synthase TruA	NA	NA	NA	NA
WP_002937466.1\|325174_325936_+	bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase	NA	NA	NA	NA
WP_002937464.1\|325925_326411_+	membrane protein	NA	NA	NA	NA
WP_002937462.1\|326391_326958_+	TIGR01440 family protein	NA	NA	NA	NA
WP_002937456.1\|326957_327572_+	DUF1349 domain-containing protein	NA	NA	NA	NA
WP_002937454.1\|327844_328276_+	Rrf2 family transcriptional regulator	NA	NA	NA	NA
WP_002937449.1\|328355_329357_+	NADP-dependent oxidoreductase	NA	NA	NA	NA
WP_014636803.1\|329382_330228_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_002937439.1\|330220_331090_+	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_002937437.1\|331082_332294_+	NADH:flavin oxidoreductase/NADH oxidase family protein	NA	NA	NA	NA
WP_002937436.1\|332560_333070_-	TetR family transcriptional regulator	NA	NA	NA	NA
WP_002937435.1\|333212_334331_+	pectin acetylesterase	NA	NA	NA	NA
WP_013730135.1\|334340_335360_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_002937432.1\|335581_336865_+	trigger factor	NA	NA	NA	NA
WP_002937352.1\|336915_337800_+	glycosyltransferase family 2 protein	NA	NA	NA	NA
WP_002937351.1\|337909_338830_+	zinc ABC transporter solute-binding protein	NA	NA	NA	NA
WP_002937350.1\|338863_342019_+	pneumococcal-type histidine triad protein	NA	NA	NA	NA
WP_094122559.1\|342099_343450_+\|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	9.7e-65	51.8
WP_011921912.1\|344549_345131_+	DNA-directed RNA polymerase subunit delta	NA	NA	NA	NA
WP_009909339.1\|345323_346928_+	CTP synthase	A0A1J0FA14	Only_Syngen_Nebraska_virus	4.4e-141	46.6
WP_013730139.1\|347539_348421_+	fructose-bisphosphate aldolase	NA	NA	NA	NA
WP_001140948.1\|348815_349004_+	50S ribosomal protein L28	NA	NA	NA	NA
WP_004194311.1\|355027_357046_+	ATP-dependent DNA helicase RecG	NA	NA	NA	NA
WP_014636805.1\|357132_358092_-	asparaginase	NA	NA	NA	NA
WP_004194297.1\|358161_359007_+	Cof-type HAD-IIB family hydrolase	NA	NA	NA	NA
WP_004194296.1\|359008_359527_+	haloacid dehalogenase	A0A0H3UZF4	Geobacillus_virus	8.9e-19	35.5
WP_004194294.1\|359542_359995_-	universal stress protein	NA	NA	NA	NA
WP_002937606.1\|360149_361364_+	pyridoxal phosphate-dependent aminotransferase	NA	NA	NA	NA
WP_014636806.1\|361834_362623_+	GTP-sensing pleiotropic transcriptional regulator CodY	NA	NA	NA	NA
WP_013730352.1\|363457_364660_+\|transposase	IS110 family transposase	A0A1X9I619	Streptococcus_phage	4.5e-223	98.5
WP_009909376.1\|365829_367311_-	UDP-glucose--hexose-1-phosphate uridylyltransferase	NA	NA	NA	NA
WP_002939036.1\|367320_368493_-	galactokinase	NA	NA	NA	NA
WP_002939037.1\|368625_369624_+	LacI family DNA-binding transcriptional regulator	C6ZCU4	Enterobacteria_phage	5.0e-10	25.7
WP_074390696.1\|369926_370082_-\|holin	putative holin-like toxin	NA	NA	NA	NA
WP_002939042.1\|370399_371839_-\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB	NA	NA	NA	NA
WP_002939044.1\|371838_373305_-\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA	NA	NA	NA	NA
WP_002939046.1\|373304_373607_-\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	NA	NA	NA	NA
WP_013730145.1\|373824_374499_-	hydrolase	NA	NA	NA	NA
WP_011921928.1\|374716_375064_-	50S ribosomal protein L19	NA	NA	NA	NA
WP_014636809.1\|375621_376824_-\|transposase	IS110 family transposase	A0A1X9I619	Streptococcus_phage	1.1e-221	97.8
WP_002935152.1\|377106_377736_+	copper homeostasis protein CutC	NA	NA	NA	NA
WP_002935151.1\|377942_378317_+	hypothetical protein	NA	NA	NA	NA
WP_002935150.1\|378500_379028_+	YqeG family HAD IIIA-type phosphatase	NA	NA	NA	NA
WP_011922650.1\|379028_380135_+	ribosome biogenesis GTPase YqeH	NA	NA	NA	NA
WP_024379048.1\|380453_380765_+	ribosome assembly RNA-binding protein YhbY	NA	NA	NA	NA
WP_002935147.1\|380777_381410_+	nicotinate-nucleotide adenylyltransferase	G3MA22	Bacillus_virus	2.0e-20	33.8
WP_002935146.1\|381406_381994_+	HD domain-containing protein	NA	NA	NA	NA
WP_002935141.1\|382448_382958_+	cysteine hydrolase	NA	NA	NA	NA
WP_002935140.1\|382959_383319_+	ribosome silencing factor	NA	NA	NA	NA
WP_024390907.1\|384070_384817_+	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_029694371.1\|384829_386599_+	hypothetical protein	NA	NA	NA	NA
WP_002935136.1\|386642_387731_+	nucleotidyltransferase	NA	NA	NA	NA
WP_002935135.1\|387732_388113_+	TipAS antibiotic-recognition domain-containing protein	NA	NA	NA	NA
WP_014636745.1\|388267_389557_-\|transposase	IS4-like element ISSsu2 family transposase	NA	NA	NA	NA
WP_004194216.1\|391084_391495_+	peptide deformylase	A0A2I7QLT9	Vibrio_phage	2.1e-10	34.2
WP_013730153.1\|391909_394009_+\|protease	ATP-dependent Clp protease ATP-binding subunit	H6X3M6	Enterobacteria_phage	7.4e-120	38.1

DBSCAN-SWA_3

474503 : 542960

Streptococcus_phage(18.18%)

tRNA,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_094122540.1\|474503_475351_-\|transposase	IS630 family transposase	S5VXX4	Leptospira_phage	1.5e-07	26.6
WP_004194478.1\|475863_476124_+	hypothetical protein	NA	NA	NA	NA
WP_004194476.1\|476116_476707_+	signal peptidase I	NA	NA	NA	NA
WP_014636745.1\|480948_482238_+\|transposase	IS4-like element ISSsu2 family transposase	NA	NA	NA	NA
WP_014636821.1\|482380_483211_+	class C sortase	NA	NA	NA	NA
WP_013730206.1\|483772_485122_+	UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase	NA	NA	NA	NA
WP_002938780.1\|485124_486189_+	UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase	NA	NA	NA	NA
WP_002938782.1\|486194_487289_+	FtsQ-type POTRA domain-containing protein	NA	NA	NA	NA
WP_002938790.1\|487441_488821_+	cell division protein FtsA	NA	NA	NA	NA
WP_002938797.1\|488846_490076_+	cell division protein FtsZ	NA	NA	NA	NA
WP_002938805.1\|490082_490754_+	YggS family pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_009909461.1\|490770_491340_+	cell division protein SepF	NA	NA	NA	NA
WP_002938809.1\|491344_491608_+	YggT family protein	NA	NA	NA	NA
WP_002938812.1\|491610_492402_+	RNA-binding protein	NA	NA	NA	NA
WP_002938821.1\|492410_493100_+	DivIVA domain-containing protein	NA	NA	NA	NA
WP_002938828.1\|493330_493774_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_014636823.1\|496655_497912_-\|transposase	ISL3 family transposase	A0A1S5SBP9	Streptococcus_phage	2.6e-173	73.9
WP_162096931.1\|498218_499511_-\|transposase	IS110-like element ISSsu7 family transposase	A0A1X9I619	Streptococcus_phage	1.3e-223	99.2
WP_014636826.1\|499997_500306_-	DUF1827 family protein	NA	NA	NA	NA
WP_002938708.1\|500360_500822_-	NUDIX hydrolase	NA	NA	NA	NA
WP_002938704.1\|503434_503665_+	DUF1797 family protein	NA	NA	NA	NA
WP_014636745.1\|503819_505109_-\|transposase	IS4-like element ISSsu2 family transposase	NA	NA	NA	NA
WP_002938702.1\|505304_505994_+	amino acid ABC transporter permease	NA	NA	NA	NA
WP_002938699.1\|505986_506721_+	amino acid ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	7.9e-37	41.1
WP_002938697.1\|506850_507699_+	bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase	A0A249XZQ2	Enterococcus_phage	1.0e-40	42.0
WP_002938694.1\|509136_509430_+	hypothetical protein	NA	NA	NA	NA
WP_009909468.1\|509419_510022_+	signal peptidase I	NA	NA	NA	NA
WP_002938691.1\|510040_510427_+	hypothetical protein	NA	NA	NA	NA
WP_022540576.1\|510784_511612_+	class C sortase	NA	NA	NA	NA
WP_002938688.1\|512018_512429_+	MerR family transcriptional regulator	NA	NA	NA	NA
WP_002938687.1\|512450_512765_-	DUF3270 domain-containing protein	NA	NA	NA	NA
WP_002938686.1\|512925_513855_+	U32 family peptidase	NA	NA	NA	NA
WP_041179058.1\|514032_515319_+	U32 family peptidase	Q6DW11	Phage_TP	2.7e-40	31.2
WP_014636828.1\|515531_515855_-	hypothetical protein	NA	NA	NA	NA
WP_004194749.1\|515946_516162_+	hypothetical protein	NA	NA	NA	NA
WP_004194750.1\|516173_516713_-	biotin transporter BioY	NA	NA	NA	NA
WP_004194751.1\|516918_517563_+	cyclase family protein	NA	NA	NA	NA
WP_004194752.1\|517706_519056_-	glutathione-disulfide reductase	NA	NA	NA	NA
WP_004194758.1\|520229_521387_+	efflux RND transporter periplasmic adaptor subunit	NA	NA	NA	NA
WP_004194759.1\|521367_522063_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	4.1e-35	41.2
WP_004194760.1\|522063_523311_+	FtsX-like permease family protein	NA	NA	NA	NA
WP_014636829.1\|523436_524501_+	LLM class flavin-dependent oxidoreductase	NA	NA	NA	NA
WP_002938493.1\|524884_525727_+	GIY-YIG nuclease family protein	NA	NA	NA	NA
WP_002938486.1\|525723_526860_+	hypothetical protein	NA	NA	NA	NA
WP_009909483.1\|527208_528699_-\|tRNA	lysine--tRNA ligase	A0A1V0SAC0	Catovirus	8.7e-91	40.9
WP_002938482.1\|528801_529428_-	histidine phosphatase family protein	NA	NA	NA	NA
WP_002938479.1\|529430_529913_-\|tRNA	aminoacyl-tRNA deacylase	NA	NA	NA	NA
WP_009909486.1\|529912_530755_-	DUF368 domain-containing protein	NA	NA	NA	NA
WP_002938477.1\|530857_531406_-	energy-coupled thiamine transporter ThiT	NA	NA	NA	NA
WP_002938476.1\|531583_532438_-	N-acetylmuramoyl-L-alanine amidase	A0A2K5B2A3	Erysipelothrix_phage	1.9e-10	27.9
WP_002938471.1\|532550_533054_+	hypothetical protein	NA	NA	NA	NA
WP_002938468.1\|533050_533416_+	DUF4430 domain-containing protein	NA	NA	NA	NA
WP_002938463.1\|533552_534767_+	FtsW/RodA/SpoVE family cell cycle protein	NA	NA	NA	NA
WP_014636830.1\|534787_537484_+	phosphoenolpyruvate carboxylase	NA	NA	NA	NA
WP_024390428.1\|537598_538102_+	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_009909491.1\|538082_539054_+	hypothetical protein	NA	NA	NA	NA
WP_012775011.1\|539409_540606_+	elongation factor Tu	A0A076FFS6	Aureococcus_anophage	2.5e-32	28.2
WP_004298713.1\|540780_541533_+	triose-phosphate isomerase	NA	NA	NA	NA
WP_087013902.1\|541609_542960_+\|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	9.7e-65	51.8

DBSCAN-SWA_4

617077 : 623409

Bacillus_phage(33.33%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002935839.1\|617077_617839_-	amino acid ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	5.0e-34	38.4
WP_002935840.1\|618032_618737_+	response regulator transcription factor	W8CYM9	Bacillus_phage	8.1e-39	39.8
WP_002935841.1\|618729_620079_+	cell wall metabolism sensor histidine kinase VicK	W8CYF6	Bacillus_phage	2.1e-35	34.5
WP_002935843.1\|620085_620889_+	MBL fold metallo-hydrolase	A0A0C5AJ83	Bacteriophage	3.6e-35	35.6
WP_014636845.1\|621512_622715_-\|transposase	IS110 family transposase	A0A1X9I619	Streptococcus_phage	4.5e-215	94.0
WP_002935846.1\|622953_623409_+	ABC-F family ATP-binding cassette domain-containing protein	A0A1B0RXA0	Streptococcus_phage	2.6e-14	31.9

DBSCAN-SWA_5

713821 : 744188

Streptococcus_phage(80.95%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_004194722.1\|713821_715996_-	LTA synthase family protein	W6LM83	Streptococcus_phage	1.1e-230	60.3
WP_004194720.1\|716111_717275_+	class I SAM-dependent rRNA methyltransferase	W6LLI2	Streptococcus_phage	2.1e-140	64.7
WP_004194719.1\|717271_717946_+	type I 3-dehydroquinate dehydratase	W6LP76	Streptococcus_phage	7.7e-79	64.6
WP_004194717.1\|717949_719116_+	chorismate synthase	A0A291AU41	Pandoravirus	3.5e-39	34.9
WP_004194716.1\|719123_720227_+	prephenate dehydrogenase	NA	NA	NA	NA
WP_002938966.1\|720236_720575_+	YlbF/YmcA family competence regulator	A0A1X9I5Y8	Streptococcus_phage	1.9e-54	100.0
WP_014636863.1\|720877_722080_-\|transposase	IS110 family transposase	A0A1X9I619	Streptococcus_phage	4.7e-212	93.2
WP_002938932.1\|723794_724433_-	MBL fold metallo-hydrolase	A0A1X9I5D3	Streptococcus_phage	6.7e-125	99.1
WP_014636865.1\|724495_727009_+	bifunctional DnaQ family exonuclease/ATP-dependent helicase	A0A1X9I5C8	Streptococcus_phage	0.0e+00	98.2
WP_002938922.1\|727169_728246_+	glutamate 5-kinase	A0A1X9I5D0	Streptococcus_phage	3.1e-191	98.0
WP_014636866.1\|728255_729494_+	glutamate-5-semialdehyde dehydrogenase	A0A1X9I5D4	Streptococcus_phage	3.2e-216	96.6
WP_014636867.1\|729503_730289_+	pyrroline-5-carboxylate reductase	A0A1X9I6T5	Streptococcus_phage	2.6e-134	97.7
WP_014636745.1\|730400_731690_+\|transposase	IS4-like element ISSsu2 family transposase	NA	NA	NA	NA
WP_011922106.1\|731824_732229_-	TetR/AcrR family transcriptional regulator	A0A1X9I6A2	Streptococcus_phage	3.2e-64	99.3
WP_014636868.1\|732355_733207_+	DegV family protein	A0A1X9I5J4	Streptococcus_phage	2.0e-153	98.9
WP_013730273.1\|733305_734565_-	PLP-dependent aminotransferase family protein	A0A1X9I5H2	Streptococcus_phage	2.7e-242	99.8
WP_024381470.1\|734687_735422_+	peroxide stress protein YaaA	A0A1X9I5I0	Streptococcus_phage	7.7e-117	96.3
WP_014636869.1\|735551_736991_+	LCP family protein	A0A1X9I5X1	Streptococcus_phage	7.3e-204	88.8
WP_014636870.1\|737006_737696_+	capsular polysaccharide biosynthesis protein CpsC	A0A1X9I5E1	Streptococcus_phage	1.4e-107	92.1
WP_014636871.1\|737705_738392_+	tyrosine-protein kinase	A0A1X9I5D6	Streptococcus_phage	3.1e-104	91.6
WP_013730278.1\|738430_739162_+	tyrosine protein phosphatase	NA	NA	NA	NA
WP_014636872.1\|739191_741018_+	polysaccharide biosynthesis protein	A0A1V0SAI8	Catovirus	4.6e-25	27.1
WP_014636873.1\|741462_742161_+	sugar transferase	NA	NA	NA	NA
WP_014636874.1\|742170_743385_+	DegT/DnrJ/EryC1/StrS family aminotransferase	A0A2P1ELT3	Moumouvirus	1.6e-26	26.7
WP_032499146.1\|743417_744188_+	glycosyltransferase	A0A1V0SAH6	Catovirus	1.4e-15	38.9

DBSCAN-SWA_6

797953 : 869574

Streptococcus_phage(69.57%)

tRNA,transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002937231.1\|797953_798982_-\|tRNA	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	NA	NA	NA	NA
WP_002937230.1\|799329_800034_+	glucosamine-6-phosphate deaminase	NA	NA	NA	NA
WP_014636895.1\|800370_803733_+	LPXTG cell wall anchor domain-containing protein	NA	NA	NA	NA
WP_002937228.1\|803879_804839_+	glycosyltransferase family 2 protein	F1C5B0	Cronobacter_phage	5.3e-49	37.1
WP_013730308.1\|804853_807748_+	YfhO family protein	NA	NA	NA	NA
WP_002937222.1\|807781_808228_+	GtrA family protein	NA	NA	NA	NA
WP_002937220.1\|808968_809316_+	hypothetical protein	NA	NA	NA	NA
WP_002937217.1\|809736_810051_+	hypothetical protein	NA	NA	NA	NA
WP_014636896.1\|810481_810826_+	hypothetical protein	NA	NA	NA	NA
WP_014636897.1\|810935_811280_+	hypothetical protein	NA	NA	NA	NA
WP_002937209.1\|811751_811877_+	teichoic acid D-Ala incorporation-associated protein DltX	NA	NA	NA	NA
WP_002937207.1\|811893_813429_+	D-alanine--poly(phosphoribitol) ligase subunit DltA	A0A2K9KZV5	Tupanvirus	5.7e-37	26.6
WP_002937200.1\|813425_814667_+	D-alanyl-lipoteichoic acid biosynthesis protein DltB	A0A125RNP0	Pseudomonas_phage	6.0e-21	29.3
WP_002937198.1\|814709_814949_+	D-alanine--poly(phosphoribitol) ligase subunit DltC	NA	NA	NA	NA
WP_002937195.1\|814941_816207_+	D-alanyl-lipoteichoic acid biosynthesis protein DltD	NA	NA	NA	NA
WP_002937193.1\|816295_817411_-	low temperature requirement A	NA	NA	NA	NA
WP_002937191.1\|817870_818833_-	glutathione S-transferase family protein	NA	NA	NA	NA
WP_002937189.1\|818971_819688_+	rRNA pseudouridine synthase	NA	NA	NA	NA
WP_014636898.1\|819701_820181_+	glutathione peroxidase	NA	NA	NA	NA
WP_014636899.1\|820199_821201_-	iron ABC transporter permease	NA	NA	NA	NA
WP_002937183.1\|821197_822223_-	iron ABC transporter permease	A0A2H4IY97	uncultured_Caudovirales_phage	1.2e-14	27.3
WP_002937175.1\|822236_823166_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_014636900.1\|823178_823964_-	ABC transporter ATP-binding protein	M1I1A6	Acanthocystis_turfacea_Chlorella_virus	2.7e-06	23.7
WP_014636901.1\|825687_826434_+	1-acyl-sn-glycerol-3-phosphate acyltransferase	NA	NA	NA	NA
WP_002935348.1\|826500_827163_+	competence protein CelA	NA	NA	NA	NA
WP_014636902.1\|827146_829384_+	DNA internalization-related competence protein ComEC/Rec2	M1PSD2	Streptococcus_phage	1.4e-97	94.0
WP_002935351.1\|829385_829529_+\|transposase	transposase	NA	NA	NA	NA
WP_002935353.1\|829707_830364_+	CBS domain-containing protein	M1NSC5	Streptococcus_phage	2.1e-113	99.1
WP_014636903.1\|830648_831938_-\|transposase	IS4-like element ISSsu2 family transposase	NA	NA	NA	NA
WP_002935355.1\|832803_834075_+	hypothetical protein	M1PLC8	Streptococcus_phage	1.7e-212	100.0
WP_002935357.1\|834111_834978_-	YitT family protein	M1Q1P6	Streptococcus_phage	4.6e-153	99.7
WP_002935358.1\|835152_835791_+	dTMP kinase	M1PSC7	Streptococcus_phage	2.6e-113	98.6
WP_002935359.1\|835787_836672_+	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	3.6e-153	98.3
WP_002935361.1\|836691_837009_+	DNA replication initiation control protein YabA	M1PFV3	Streptococcus_phage	3.1e-54	100.0
WP_002935362.1\|837010_837874_+	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	2.1e-158	99.7
WP_002935363.1\|838343_839435_+	3-phosphoserine/phosphohydroxythreonine transaminase	M1Q1P2	Streptococcus_phage	1.5e-204	98.6
WP_002935364.1\|839434_839992_+	GNAT family acetyltransferase	M1PSC3	Streptococcus_phage	4.5e-93	98.4
WP_014636905.1\|840365_841547_+	phosphoglycerate dehydrogenase	M1NSB9	Streptococcus_phage	3.0e-219	99.5
WP_002935366.1\|841549_842056_+	methylated-DNA--[protein]-cysteine S-methyltransferase	M1PFU9	Streptococcus_phage	1.2e-92	97.0
WP_002935368.1\|842039_842393_+	arsenate reductase family protein	M1PLC0	Streptococcus_phage	1.9e-60	100.0
WP_009909675.1\|842409_843309_-	cation transporter	M1Q1N9	Streptococcus_phage	1.3e-161	98.3
WP_002935370.1\|843608_844436_-	exodeoxyribonuclease III	M1PSC0	Streptococcus_phage	8.3e-152	99.6
WP_014636906.1\|844591_846253_+	hypothetical protein	NA	NA	NA	NA
WP_014636907.1\|846412_847771_+	amino acid permease	NA	NA	NA	NA
WP_094122545.1\|847809_848656_+\|transposase	IS630 family transposase	S5VXX4	Leptospira_phage	1.1e-08	25.4
WP_002935373.1\|848821_849703_+	DUF975 family protein	NA	NA	NA	NA
WP_014636909.1\|849895_850732_+	DUF975 family protein	NA	NA	NA	NA
WP_014636910.1\|850749_851625_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_002935377.1\|851747_852359_+	DUF3885 domain-containing protein	NA	NA	NA	NA
WP_002935380.1\|855316_857239_+	DEAD/DEAH box helicase family protein	NA	NA	NA	NA
WP_029694137.1\|857515_858394_+	GIY-YIG nuclease family protein	NA	NA	NA	NA
WP_002935387.1\|858718_859465_+	hypothetical protein	NA	NA	NA	NA
WP_002935389.1\|860316_862035_-	phospho-sugar mutase	A0A1X9I671	Streptococcus_phage	0.0e+00	99.0
WP_002935390.1\|862125_862695_-	ECF transporter S component	NA	NA	NA	NA
WP_002935392.1\|862681_863230_-	phosphopantothenoylcysteine decarboxylase	A0A068EHP1	Penguinpox_virus	2.8e-23	37.8
WP_022540619.1\|863222_863918_-	phosphopantothenate--cysteine ligase	NA	NA	NA	NA
WP_014636911.1\|864421_866095_+	formate--tetrahydrofolate ligase	NA	NA	NA	NA
WP_002935395.1\|866138_866948_-\|protease	PrsW family intramembrane metalloprotease	NA	NA	NA	NA
WP_002935400.1\|868722_869574_-\|protease	PrsW family intramembrane metalloprotease	NA	NA	NA	NA

DBSCAN-SWA_7

1041897 : 1050577

Streptococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000578719.1\|1041897_1042374_-	helix-turn-helix transcriptional regulator	X2CXD8	Lactobacillus_phage	3.6e-06	34.8
WP_000667951.1\|1042443_1042734_-	hypothetical protein	NA	NA	NA	NA
WP_000048066.1\|1042784_1043174_-	hypothetical protein	NA	NA	NA	NA
WP_000110922.1\|1043170_1043398_-	hypothetical protein	NA	NA	NA	NA
WP_000196860.1\|1043425_1044526_-	hypothetical protein	NA	NA	NA	NA
WP_014636934.1\|1044589_1046284_-	DUF4368 domain-containing protein	A0A288WFZ3	Bacillus_phage	9.1e-20	25.5
WP_000409924.1\|1046400_1047255_+	ParA family protein	A0A1X9I765	Streptococcus_phage	4.1e-154	99.3
WP_002321610.1\|1047346_1047562_+	peptide-binding protein	A0A1X9I6D5	Streptococcus_phage	1.4e-31	98.6
WP_014636935.1\|1047771_1048509_+	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B)	E4ZFQ0	Streptococcus_phage	5.3e-134	99.2
WP_073459356.1\|1048654_1048939_+	topoisomerase	A0A1X9I6W8	Streptococcus_phage	2.3e-40	93.0
WP_000253176.1\|1049183_1049447_-	hypothetical protein	NA	NA	NA	NA
WP_001206986.1\|1049446_1049677_-	hypothetical protein	A0A223LEC3	Bacillus_phage	3.2e-13	48.5
WP_000743700.1\|1049722_1050577_-	ParB/RepB/Spo0J family partition protein	S5VSZ7	Leptospira_phage	1.7e-06	30.2

DBSCAN-SWA_8

1086480 : 1096682

Streptococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014636958.1\|1086480_1087836_-	DNA (cytosine-5-)-methyltransferase	A0A141E1L1	Streptococcus_phage	2.0e-126	55.2
WP_014636959.1\|1087984_1088803_-	replication initiator protein A	A0A286QNA4	Streptococcus_phage	2.2e-11	36.6
WP_014636961.1\|1089172_1089538_-	50S ribosomal protein L7/L12	NA	NA	NA	NA
WP_002936486.1\|1089603_1090098_-	50S ribosomal protein L10	NA	NA	NA	NA
WP_014636962.1\|1090674_1092768_-	type I DNA topoisomerase	A0A1V0SCS0	Indivirus	2.4e-102	36.5
WP_009909860.1\|1092860_1093703_-	DNA-protecting protein DprA	S6BFL3	Thermus_phage	4.7e-33	44.3
WP_009909862.1\|1093761_1094319_-	sugar O-acetyltransferase	A0A191KBJ5	Streptococcus_virus	4.9e-07	38.6
WP_009909865.1\|1094329_1094590_-	metal-sensitive transcriptional regulator	NA	NA	NA	NA
WP_002936496.1\|1095029_1096682_+	pyridine nucleotide-disulfide oxidoreductase family protein	A0A2K5B2C5	Erysipelothrix_phage	6.2e-13	24.3

DBSCAN-SWA_9

1170276 : 1211302

Leptospira_phage(33.33%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014636745.1\|1170276_1171566_-\|transposase	IS4-like element ISSsu2 family transposase	NA	NA	NA	NA
WP_002935167.1\|1177615_1179601_-	excinuclease ABC subunit B	NA	NA	NA	NA
WP_014637017.1\|1180457_1182656_+	ABC transporter permease subunit	NA	NA	NA	NA
WP_002935170.1\|1182655_1183396_+	amino acid ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	4.5e-32	40.1
WP_002935171.1\|1183451_1183943_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_002935173.1\|1184242_1185775_+	ABC-F family ATP-binding cassette domain-containing protein	A0A2H4UUX5	Bodo_saltans_virus	8.8e-30	23.2
WP_094122551.1\|1187902_1188750_-\|transposase	IS630 family transposase	S5VXX4	Leptospira_phage	6.8e-08	24.4
WP_002935185.1\|1190426_1191179_-\|transposase	transposase	NA	NA	NA	NA
WP_002935183.1\|1191389_1191740_-	IS66 family insertion sequence element accessory protein TnpB	NA	NA	NA	NA
WP_002935182.1\|1191720_1191906_-	hypothetical protein	NA	NA	NA	NA
WP_014637021.1\|1193693_1194422_-	LPXTG cell wall anchor domain-containing protein	NA	NA	NA	NA
WP_029694380.1\|1194606_1195197_-	recombinase family protein	M9Q1K0	Clostridium_phage	8.6e-10	28.0
WP_094122540.1\|1195245_1196092_+\|transposase	IS630 family transposase	S5VXX4	Leptospira_phage	1.5e-07	26.6
WP_002935191.1\|1196664_1198431_-	L-fucose isomerase	NA	NA	NA	NA
WP_002935195.1\|1199641_1201933_-	glycoside hydrolase family 95 protein	NA	NA	NA	NA
WP_014637022.1\|1201990_1202791_-	PTS mannose/fructose/sorbose transporter family subunit IID	NA	NA	NA	NA
WP_002935201.1\|1202787_1203561_-	PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC	NA	NA	NA	NA
WP_002935202.1\|1203583_1204054_-	PTS sugar transporter subunit IIB	NA	NA	NA	NA
WP_014637023.1\|1204044_1204476_-	PTS sugar transporter subunit IIA	NA	NA	NA	NA
WP_002935205.1\|1204468_1204909_-	fucose isomerase	NA	NA	NA	NA
WP_002935206.1\|1204920_1205559_-	L-fuculose-phosphate aldolase	NA	NA	NA	NA
WP_002935207.1\|1205669_1207073_-	rhamnulokinase	NA	NA	NA	NA
WP_002935208.1\|1207249_1208014_+	DeoR/GlpR transcriptional regulator	NA	NA	NA	NA
WP_002935210.1\|1209107_1210061_+\|transposase	IS30 family transposase	H7BWC8	unidentified_phage	1.1e-38	33.2
WP_002935211.1\|1210297_1211302_+\|transposase	IS5 family transposase	NA	NA	NA	NA

DBSCAN-SWA_10

1375755 : 1429165

Klosneuvirus(16.67%)

tRNA,transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014637045.1\|1375755_1376850_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_002936095.1\|1376957_1377632_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_002936096.1\|1377641_1377959_-	hypothetical protein	NA	NA	NA	NA
WP_012775187.1\|1377968_1378658_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_009910094.1\|1378683_1378890_-	hypothetical protein	NA	NA	NA	NA
WP_013730414.1\|1378911_1379670_-	DUF3169 family protein	NA	NA	NA	NA
WP_009910096.1\|1379666_1379882_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_013730415.1\|1379894_1380461_-	DUF3267 domain-containing protein	NA	NA	NA	NA
WP_094122545.1\|1380837_1381684_+\|transposase	IS630 family transposase	S5VXX4	Leptospira_phage	1.1e-08	25.4
WP_002938097.1\|1381907_1382360_-	cytidine deaminase	NA	NA	NA	NA
WP_014637048.1\|1382434_1385053_-\|tRNA	alanine--tRNA ligase	A0A1V0SK38	Klosneuvirus	2.5e-61	34.0
WP_002938099.1\|1385332_1385818_-	hypothetical protein	NA	NA	NA	NA
WP_002938100.1\|1386082_1387084_-	peptidylprolyl isomerase PrsA	NA	NA	NA	NA
WP_009910106.1\|1387144_1387864_-	O-methyltransferase	NA	NA	NA	NA
WP_002938103.1\|1387938_1388487_-	hypothetical protein	NA	NA	NA	NA
WP_002938105.1\|1388502_1388943_-	hypothetical protein	NA	NA	NA	NA
WP_009910108.1\|1388944_1390747_-	oligoendopeptidase F	NA	NA	NA	NA
WP_002938107.1\|1390978_1391920_-	competence protein CoiA	NA	NA	NA	NA
WP_094122553.1\|1391983_1394041_-\|tRNA	methionine--tRNA ligase	A0A1V0SHR2	Klosneuvirus	5.8e-85	36.0
WP_002938116.1\|1394140_1394734_+	DUF1361 domain-containing protein	NA	NA	NA	NA
WP_002938119.1\|1395034_1396072_+	3-deoxy-7-phosphoheptulonate synthase	S4W5F1	Pandoravirus	2.2e-45	34.3
WP_002938121.1\|1396081_1397107_+	3-deoxy-7-phosphoheptulonate synthase	S4W5F1	Pandoravirus	3.2e-44	35.2
WP_002938123.1\|1397152_1398022_+	shikimate dehydrogenase	NA	NA	NA	NA
WP_014637050.1\|1398034_1399102_+	3-dehydroquinate synthase	NA	NA	NA	NA
WP_002938126.1\|1399305_1400106_-	ATP-binding cassette domain-containing protein	W6JKT0	Anomala_cuprea_entomopoxvirus	9.0e-10	23.8
WP_013730419.1\|1400115_1401009_-	ABC transporter permease	NA	NA	NA	NA
WP_013730420.1\|1401063_1402038_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_013730421.1\|1402061_1403021_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_013730422.1\|1403761_1404763_-	tagatose-bisphosphate aldolase	NA	NA	NA	NA
WP_014637051.1\|1404786_1405932_-	N-acetylglucosamine-6-phosphate deacetylase	NA	NA	NA	NA
WP_014637052.1\|1406438_1407281_-	amino acid ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_014637053.1\|1407295_1407928_-	amino acid ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	3.9e-32	39.3
WP_014637054.1\|1407937_1408579_-	amino acid ABC transporter permease	NA	NA	NA	NA
WP_014637055.1\|1408732_1410544_-	glutamine--fructose-6-phosphate transaminase (isomerizing)	Q84421	Paramecium_bursaria_Chlorella_virus	9.5e-100	37.6
WP_014637056.1\|1410850_1412107_+\|transposase	ISL3 family transposase	A0A1S5SBP9	Streptococcus_phage	4.8e-127	56.1
WP_002935515.1\|1412157_1412700_-	signal peptidase I	NA	NA	NA	NA
WP_002935518.1\|1412742_1413360_-	esterase	NA	NA	NA	NA
WP_002935524.1\|1413444_1414554_+	FAD-binding oxidoreductase	NA	NA	NA	NA
WP_002935529.1\|1415702_1418786_-	YSIRK-type signal peptide-containing protein	NA	NA	NA	NA
WP_002935530.1\|1418946_1420452_-	pyruvate kinase	NA	NA	NA	NA
WP_002935531.1\|1420518_1421529_-	6-phosphofructokinase	NA	NA	NA	NA
WP_002935534.1\|1421613_1424724_-	DNA polymerase III subunit alpha	A0A1C9LWZ5	Streptomyces_phage	3.2e-119	29.3
WP_002935537.1\|1424881_1425256_+	GntR family transcriptional regulator	NA	NA	NA	NA
WP_002935539.1\|1425248_1425956_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	2.1e-18	26.1
WP_002935541.1\|1425972_1426755_+	hypothetical protein	NA	NA	NA	NA
WP_002935542.1\|1426798_1427800_-	adenosine deaminase	NA	NA	NA	NA
WP_011922710.1\|1428001_1429165_+\|transposase	IS30 family transposase	H7BWC8	unidentified_phage	8.2e-12	24.9

DBSCAN-SWA_11

1902104 : 1970839

Streptococcus_phage(20.0%)

tRNA,transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_162096930.1\|1902104_1903397_+\|transposase	IS110-like element ISSsu7 family transposase	A0A1X9I619	Streptococcus_phage	8.8e-225	99.8
WP_002942223.1\|1904362_1904755_-	30S ribosomal protein S9	NA	NA	NA	NA
WP_013730573.1\|1904774_1905221_-	50S ribosomal protein L13	NA	NA	NA	NA
WP_002939460.1\|1905684_1906548_-	DegV family protein	NA	NA	NA	NA
WP_002939458.1\|1906544_1907066_-	NYN domain-containing protein	NA	NA	NA	NA
WP_002939457.1\|1907066_1907795_-	23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB	NA	NA	NA	NA
WP_013730574.1\|1907932_1908322_+	DUF1761 domain-containing protein	NA	NA	NA	NA
WP_002938836.1\|1908396_1909365_+	aromatic acid exporter family protein	NA	NA	NA	NA
WP_014637174.1\|1909451_1910741_+\|transposase	IS4-like element ISSsu2 family transposase	NA	NA	NA	NA
WP_014637175.1\|1910947_1912240_+\|transposase	IS110-like element ISSsu7 family transposase	A0A1X9I619	Streptococcus_phage	5.7e-224	99.2
WP_002938838.1\|1912542_1913673_-	sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC	G9BWD6	Planktothrix_phage	3.6e-20	32.6
WP_002938840.1\|1913782_1914637_-	transcriptional regulator	NA	NA	NA	NA
WP_002938842.1\|1914638_1915037_-	Mini-ribonuclease 3	NA	NA	NA	NA
WP_014637176.1\|1915029_1916373_-\|tRNA	cysteine--tRNA ligase	A0A1V0SAQ2	Catovirus	7.2e-52	35.5
WP_014637177.1\|1916383_1916569_-	hypothetical protein	NA	NA	NA	NA
WP_014637178.1\|1916653_1917514_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_014637180.1\|1918211_1920431_-	polyribonucleotide nucleotidyltransferase	NA	NA	NA	NA
WP_002938849.1\|1920821_1921091_-	30S ribosomal protein S15	NA	NA	NA	NA
WP_002938850.1\|1921345_1921987_-	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	2.7e-33	38.1
WP_002938851.1\|1921979_1922711_-	hypothetical protein	NA	NA	NA	NA
WP_002938853.1\|1923474_1924239_-	hypothetical protein	NA	NA	NA	NA
WP_013730575.1\|1924323_1924734_-	hypothetical protein	NA	NA	NA	NA
WP_002938352.1\|1924967_1926245_-	uracil transporter	Q9KX94	Enterobacteria_phage	3.0e-60	37.7
WP_002938355.1\|1926667_1927177_-	hypothetical protein	NA	NA	NA	NA
WP_014637181.1\|1927554_1928226_-	rRNA pseudouridine synthase	NA	NA	NA	NA
WP_009910851.1\|1928216_1928666_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_009910852.1\|1928879_1930043_-	MFS transporter	NA	NA	NA	NA
WP_013730579.1\|1930172_1930787_+	peptide deformylase	E3SLL2	Synechococcus_phage	7.9e-14	40.5
WP_009910855.1\|1930975_1931761_-	translation factor Sua5	NA	NA	NA	NA
WP_009910856.1\|1931823_1932417_-	3-isopropylmalate dehydratase small subunit	NA	NA	NA	NA
WP_009910857.1\|1932416_1933808_-	3-isopropylmalate dehydratase large subunit	NA	NA	NA	NA
WP_002938397.1\|1934864_1936427_-	2-isopropylmalate synthase	E5EQ69	Micromonas_sp._RCC1109_virus	2.3e-09	31.9
WP_002938398.1\|1936990_1937224_-	GlsB/YeaQ/YmgE family stress response membrane protein	NA	NA	NA	NA
WP_002938399.1\|1937432_1938674_-	aminopeptidase	NA	NA	NA	NA
WP_014637182.1\|1939264_1939867_-	nitroreductase family protein	NA	NA	NA	NA
WP_014637183.1\|1940102_1940774_-	hypothetical protein	NA	NA	NA	NA
WP_014637184.1\|1940785_1945177_-	PolC-type DNA polymerase III	A0A0A7RWA3	Clostridium_phage	1.3e-17	31.2
WP_014637185.1\|1945255_1946290_-	DhaKLM operon coactivator DhaQ	NA	NA	NA	NA
WP_009910868.1\|1946300_1946846_-	dihydroxyacetone kinase transcriptional activator DhaS	NA	NA	NA	NA
WP_024386768.1\|1946993_1947983_+	dihydroxyacetone kinase subunit DhaK	NA	NA	NA	NA
WP_014637187.1\|1947993_1948569_+	dihydroxyacetone kinase subunit L	NA	NA	NA	NA
WP_002938758.1\|1948565_1948940_+	PTS-dependent dihydroxyacetone kinase phosphotransferase subunit DhaM	NA	NA	NA	NA
WP_014637188.1\|1948949_1949660_+	aquaporin family protein	M1HBN0	Acanthocystis_turfacea_Chlorella_virus	5.9e-29	34.9
WP_162096930.1\|1950169_1951462_-\|transposase	IS110-like element ISSsu7 family transposase	A0A1X9I619	Streptococcus_phage	8.8e-225	99.8
WP_024390942.1\|1951619_1953482_-\|tRNA	proline--tRNA ligase	NA	NA	NA	NA
WP_014637190.1\|1953705_1954965_-\|protease	RIP metalloprotease RseP	NA	NA	NA	NA
WP_014637191.1\|1954974_1955781_-	phosphatidate cytidylyltransferase	NA	NA	NA	NA
WP_014637192.1\|1955777_1956524_-	isoprenyl transferase	R9W0U9	Flavobacterium_phage	2.8e-21	41.3
WP_014637193.1\|1956637_1956961_-	preprotein translocase subunit YajC	NA	NA	NA	NA
WP_002937782.1\|1957070_1958363_-	adenylosuccinate synthase	L7Y4J5	Megavirus	2.8e-69	36.2
WP_002937783.1\|1958727_1960959_+	bifunctional glutamate--cysteine ligase GshA/glutathione synthetase GshB	NA	NA	NA	NA
WP_014637195.1\|1961526_1964646_+	LPXTG cell wall anchor domain-containing protein	NA	NA	NA	NA
WP_014637196.1\|1964725_1965592_+	Hsp33 family molecular chaperone HslO	NA	NA	NA	NA
WP_014637197.1\|1965584_1966589_+\|tRNA	tRNA dihydrouridine synthase DusB	NA	NA	NA	NA
WP_002937789.1\|1966702_1966945_-	hypothetical protein	NA	NA	NA	NA
WP_002937793.1\|1966941_1967175_-	hypothetical protein	NA	NA	NA	NA
WP_002937798.1\|1967194_1967578_-	hypothetical protein	NA	NA	NA	NA
WP_002937801.1\|1967775_1968267_-	adenylyltransferase/cytidyltransferase family protein	A0A291I9M1	Lactobacillus_phage	1.5e-23	39.4
WP_002937803.1\|1968385_1970839_-\|protease	ATP-dependent Clp protease ATP-binding subunit	H6X3M6	Enterobacteria_phage	9.8e-124	39.9

DBSCAN-SWA_12

2148853 : 2166614

Streptococcus_phage(62.5%)

integrase

attL 2153739:2153757|attR 2163341:2163359

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002938187.1\|2148853_2149690_-	energy-coupling factor transporter ATPase	G9BWD6	Planktothrix_phage	1.3e-22	32.9
WP_013730677.1\|2149686_2150226_-	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase	NA	NA	NA	NA
WP_002939074.1\|2150235_2151093_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_002939071.1\|2151174_2152458_-	insulinase family protein	NA	NA	NA	NA
WP_009911054.1\|2152454_2153708_-	insulinase family protein	A0A1X9I714	Streptococcus_phage	4.2e-232	99.0
2153739:2153757	attL	NA	NA	NA	NA
WP_013730680.1\|2154491_2155040_-	hypothetical protein	A0A1X9I5U4	Streptococcus_phage	4.7e-50	58.1
WP_013730681.1\|2155117_2155576_-	hypothetical protein	A0A1X9I5V5	Streptococcus_phage	7.6e-22	42.0
WP_013730682.1\|2155588_2156404_-	DnaD domain protein	A0A2I6QQV2	Streptococcus_phage	2.0e-81	66.0
WP_014637229.1\|2156390_2156675_-	hypothetical protein	A0A1X9I5U9	Streptococcus_phage	2.0e-36	82.8
WP_014637230.1\|2156664_2157003_-	hypothetical protein	A0A1X9I5Z6	Streptococcus_phage	6.8e-44	91.3
WP_014637232.1\|2157160_2157364_-	hypothetical protein	A0A1X9I5T6	Streptococcus_phage	1.1e-25	83.6
WP_014637233.1\|2157351_2157753_-	hypothetical protein	NA	NA	NA	NA
WP_013730688.1\|2158216_2158843_-	hypothetical protein	A0A192Y918	Salmonella_phage	9.5e-15	32.8
WP_013730689.1\|2158855_2159602_-	Bro-N domain-containing protein	A0A0A7RW33	Clostridium_phage	2.1e-24	50.7
WP_013730690.1\|2159620_2159848_-	helix-turn-helix transcriptional regulator	Q38329	Lactococcus_phage	2.8e-09	51.6
WP_013730691.1\|2160001_2160715_+	helix-turn-helix transcriptional regulator	Q708R9	Streptococcus_phage	3.7e-15	50.6
WP_041179049.1\|2161078_2161909_+	KilA-N domain-containing protein	Q4ZC41	Staphylococcus_virus	1.2e-89	62.1
WP_013730693.1\|2162073_2163246_+\|integrase	site-specific integrase	A0A1X9I5Y5	Streptococcus_phage	3.1e-216	96.9
WP_014637235.1\|2163383_2163767_+	S4 domain-containing protein YaaA	A0A1X9I5V8	Streptococcus_phage	4.6e-36	90.6
2163341:2163359	attR	NA	NA	NA	NA
WP_002936177.1\|2163769_2164864_+	DNA replication/repair protein RecF	NA	NA	NA	NA
WP_014637236.1\|2165132_2166614_-	IMP dehydrogenase	A0A1V0SHK8	Klosneuvirus	3.6e-97	41.9

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_017620

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection