CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_017278	Thermus sp. CCB_US3_UF1, complete genome	8 crisprs	c2c9_V-U4,cmr6gr7,cmr5gr11,cmr4gr7,cmr1gr7,cmr3gr5,cas10,cas1,cas3,cas6,cas8b1,cas7,cas5,cas2,DEDDh,csm2gr11,csm3gr7,csm4gr5,csm5gr7,csx1,csa3	0	8	2	0
NC_016634	Thermus sp. CCB_US3_UF1 plasmid pTCCB09, complete sequence	0 crisprs	NA	0	0	0	0

1. NC_017278

CRISPR-Cas detection and classification

Crispr_ID: NC_017278_1

• CRISPR_ID: NC_017278_1
• CRISPR_location: 87978-88188
• CRISPR_type: Orphan
• Repeat_type: I-E,II-B
• Spacer_info: 3 spacers

Consensus repeat of NC_017278_1

Consensus_repeat	Method
GTAGTCCCCACGCACGTGGGGATGGACCG	PILER-CR
GTAGTCCCCACGCACGTGGGGATGGACC	CRISPRCasFinder
GTAGTCCCCACGCACGTGGGGATGGACCG	CRT

spacers of NC_017278_1

>1.1|88007|32|NC_017278|PILER-CR,CRT
TTCCGTGCCGCCTCCCATATCTCTCCCGCCTT
>1.2|88068|31|NC_017278|PILER-CR,CRT
GCATCTTTCGCGAACATGGGCGGCGCCCCCC
>1.3|88128|32|NC_017278|PILER-CR,CRT
GGGAGGGCCTCGTTCAAAACTTCCCTCCCCTC
>1.4|88006|33|NC_017278|CRISPRCasFinder
GTTCCGTGCCGCCTCCCATATCTCTCCCGCCTT
>1.5|88067|32|NC_017278|CRISPRCasFinder
GGCATCTTTCGCGAACATGGGCGGCGCCCCCC
>1.6|88127|33|NC_017278|CRISPRCasFinder
CGGGAGGGCCTCGTTCAAAACTTCCCTCCCCTC

CRISPR arrays and Neighbor proteins around NC_017278_1

CRISPR arrays

The CRISPR arrays of NC_017278_1

>merge|NC_017278|1|87978-88188|PILER-CR,CRISPRCasFinder,CRT
GTAGTCCCCACGCACGTGGGGATGGACCGTTCCGTGCCGCCTCCCATATCTCTCCCGCCTTGTAGTCCCCACGCACGTGGGGATGGACCGGCATCTTTCGCGAACATGGGCGGCGCCCCCCGTAGTCCCCACGCACGTGGGGATGGACCCGGGAGGGCCTCGTTCAAAACTTCCCTCCCCTCGTAGTCCCCACGCACGTGGGGATGGACCG

>NC_017278|1|1|87978-88188|PILER-CR
GTAGTCCCCACGCACGTGGGGATGGACCG	TTCCGTGCCGCCTCCCATATCTCTCCCGCCTT
GTAGTCCCCACGCACGTGGGGATGGACCG	GCATCTTTCGCGAACATGGGCGGCGCCCCCC
GTAGTCCCCACGCACGTGGGGATGGACCC	GGGAGGGCCTCGTTCAAAACTTCCCTCCCCTC
GTAGTCCCCACGCACGTGGGGATGGACCG

>NC_017278|1|1|87978-88187|CRISPRCasFinder
GTAGTCCCCACGCACGTGGGGATGGACC	GTTCCGTGCCGCCTCCCATATCTCTCCCGCCTT
GTAGTCCCCACGCACGTGGGGATGGACC	GGCATCTTTCGCGAACATGGGCGGCGCCCCCC
GTAGTCCCCACGCACGTGGGGATGGACC	CGGGAGGGCCTCGTTCAAAACTTCCCTCCCCTC
GTAGTCCCCACGCACGTGGGGATGGACC

>NC_017278|1|1|87978-88188|CRT
GTAGTCCCCACGCACGTGGGGATGGACCG	TTCCGTGCCGCCTCCCATATCTCTCCCGCCTT
GTAGTCCCCACGCACGTGGGGATGGACCG	GCATCTTTCGCGAACATGGGCGGCGCCCCCC
GTAGTCCCCACGCACGTGGGGATGGACCC	GGGAGGGCCTCGTTCAAAACTTCCCTCCCCTC
GTAGTCCCCACGCACGTGGGGATGGACCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_017278.1|WP_014514492.1|84227_84686_-|YbjN-domain-containing-protein	unknown	unknown	gnl|CDD|341122
NC_017278.1|WP_014514493.1|84689_86180_-|TROVE-domain-containing-protein	unknown	unknown	gnl|CDD|368584
NC_017278.1|WP_014514502.1|94518_95715_-|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|380553
NC_017278.1|WP_014514501.1|93633_94515_-|branched-chain-amino-acid-ABC-transporter-permease	unknown	unknown	gnl|CDD|119324
NC_017278.1|WP_014514494.1|86609_87830_+|IS256-family-transposase	unknown	unknown	gnl|CDD|307151
NC_017278.1|WP_014514489.1|80320_83077_-|hypothetical-protein	unknown	unknown	gnl|CDD|350769
NC_017278.1|WP_014514500.1|92704_93637_-|branched-chain-amino-acid-ABC-transporter-permease	unknown	unknown	gnl|CDD|119323
NC_017278.1|WP_014514504.1|96443_97736_-|AMP-binding-protein	unknown	unknown	gnl|CDD|341239
NC_017278.1|WP_014514486.1|68709_74256_-|DEAD/DEAH-box-helicase	unknown	unknown	gnl|CDD|350681
NC_017278.1|WP_155983229.1|83121_83916_-|hypothetical-protein	unknown	unknown	unknown
NC_017278.1|WP_014514491.1|83941_84211_-|hypothetical-protein	unknown	unknown	unknown
NC_017278.1|WP_014514487.1|74308_76306_-|hypothetical-protein	unknown	unknown	unknown
NC_017278.1|WP_041433604.1|91977_92724_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|213186
NC_017278.1|WP_014514498.1|91294_91981_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|213191
NC_017278.1|WP_041433606.1|95725_96457_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|235546
NC_017278.1|WP_014514496.1|88549_90415_-|hypothetical-protein	unknown	unknown	gnl|CDD|197216
NC_017278.1|WP_041433607.1|98268_99429_+|acyl-CoA-dehydrogenase	unknown	unknown	gnl|CDD|173844
NC_017278.1|WP_014514488.1|76310_80309_-|N-6-DNA-methylase	unknown	unknown	gnl|CDD|280533
NC_017278.1|WP_014514505.1|97838_98378_+|MerR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|133381
NC_017278.1|WP_014514485.1|67601_68693_+|IS4-family-transposase	unknown	unknown	gnl|CDD|376573

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_017278.1|WP_014514492.1|84227_84686_-|YbjN-domain-containing-protein	gnl|CDD|341122	cd17511, YbjN_AmyR-like, YbjN protein family is structurally similar to type III secretion system chaperones. This YbjN protein family includes Escherichia coli YbjN, Erwinia amylovora AmyR, and similar proteins. YbjN proteins share a class I type III secretion chaperone (T3SC)-like fold with type III secretion system (T3SS) chaperone proteins but appear to function independently of the T3SS. YbjN is an enterobacteria-specific protein. In E. coli, it acts as a sensory transduction regulator that may play important roles in regulating bacterial multicellular behavior, metabolism, and survival under stress conditions. E. amylovora AmyR, a functionally conserved ortholog of E. coli YbjN, is a stress and virulence associated protein that regulates the ams operon. Ams proteins are required for amylovoran biosynthesis. AmyR may also regulate the Rcs phosphorelay system, an atypical two-component signal transduction (TCST) system present only in Enterobacteriaceae and positively regulates amylovoran biosynthesis by activating the ams operon transcription.	8.81873e-15
NC_017278.1|WP_014514493.1|84689_86180_-|TROVE-domain-containing-protein	gnl|CDD|368584	pfam05731, TROVE, TROVE domain. This presumed domain is found in TEP1 and Ro60 proteins, that are RNA-binding components of Telomerase, Ro and Vault RNPs. This domain has been named TROVE, (after Telomerase, Ro and Vault). This domain is probably RNA-binding.	1.81476e-14
NC_017278.1|WP_014514502.1|94518_95715_-|ABC-transporter-substrate-binding-protein	gnl|CDD|380553	cd06330, PBP1_As_SBP-like, periplasmic substrate-binding domain of active transport proteins. Periplasmic substrate-binding domain of active transport proteins found in bacteria and Archaea that is predicted to be involved in the efflux of toxic compounds. Members of this subgroup include proteins from Herminiimonas arsenicoxydans, which is resistant to arsenic (As) and various heavy metals such as cadmium and zinc. Moreover, they show significant sequence similarity to the cluster of AmiC and active transport systems for short-chain amides and urea (FmdDEF), and thus are likely to exhibit a ligand-binding mode similar to that of the amide sensor protein AmiC from Pseudomonas aeruginosa.	6.59858e-166
NC_017278.1|WP_014514501.1|93633_94515_-|branched-chain-amino-acid-ABC-transporter-permease	gnl|CDD|119324	cd06582, TM_PBP1_LivH_like, Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of branched-chain amino acids (AAs). These types of transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. E. coli LivH forms a heterodimer with another TM, LivM, to generate the transmembrane pore. LivM is not included in this subgroup. The LIV-1/LS transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) or LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine.	3.97179e-65
NC_017278.1|WP_014514494.1|86609_87830_+|IS256-family-transposase	gnl|CDD|307151	pfam00872, Transposase_mut, Transposase, Mutator family.	3.90236e-89
NC_017278.1|WP_014514488.1|76310_80309_-|N-6-DNA-methylase	gnl|CDD|280533	pfam02384, N6_Mtase, N-6 DNA Methylase. Restriction-modification (R-M) systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The R-M system is a complex containing three polypeptides: M (this family), S (pfam01420), and R. This family consists of N-6 adenine-specific DNA methylase EC:2.1.1.72 from Type I and Type IC restriction systems. These methylases have the same sequence specificity as their corresponding restriction enzymes.	2.78767e-09
NC_017278.1|WP_014514500.1|92704_93637_-|branched-chain-amino-acid-ABC-transporter-permease	gnl|CDD|119323	cd06581, TM_PBP1_LivM_like, Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of branched-chain amino acids (AAs). These types of transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. E. coli LivM forms a heterodimer with another TM, LivH, to generate the transmembrane pore. LivH is not included in this subgroup. The LIV-1/LS transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) or LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine.	1.06358e-66
NC_017278.1|WP_014514504.1|96443_97736_-|AMP-binding-protein	gnl|CDD|341239	cd05913, PaaK, Phenylacetate-CoA ligase (also known as PaaK). PaaK catalyzes the first step in the aromatic degradation pathway, by converting phenylacetic acid (PA) into phenylacetyl-CoA (PA-CoA). Phenylacetate-CoA ligase has been found in proteobacteria as well as gram positive prokaryotes. The enzyme is specifically induced after aerobic growth in a chemically defined medium containing PA or phenylalanine (Phe) as the sole carbon source. PaaKs are members of the adenylate-forming enzyme (AFE) family. However, sequence comparison reveals divergent features of PaaK with respect to the superfamily, including a novel N-terminal sequence.	1.43887e-146
NC_017278.1|WP_014514486.1|68709_74256_-|DEAD/DEAH-box-helicase	gnl|CDD|350681	cd17923, DEXHc_Hrq1-like, DEAH-box helicase domain of Hrq1 and similar proteins. Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	3.40472e-51
NC_017278.1|WP_041433604.1|91977_92724_-|ABC-transporter-ATP-binding-protein	gnl|CDD|213186	cd03219, ABC_Mj1267_LivG_branched, ATP-binding cassette component of branched chain amino acids transport system. The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E. coli branched-chain amino acid transporter. MJ1267 contains an insertion from residues 114 to 123 characteristic of LivG (Leucine-Isoleucine-Valine) homologs. The branched-chain amino acid transporter from E. coli comprises a heterodimer of ABCs (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ).	6.08875e-110
NC_017278.1|WP_014514498.1|91294_91981_-|ABC-transporter-ATP-binding-protein	gnl|CDD|213191	cd03224, ABC_TM1139_LivF_branched, ATP-binding cassette domain of branched-chain amino acid transporter. LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ). ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules.	8.92879e-108
NC_017278.1|WP_041433606.1|95725_96457_-|SDR-family-oxidoreductase	gnl|CDD|235546	PRK05653, fabG, 3-oxoacyl-ACP reductase FabG.	6.04659e-67
NC_017278.1|WP_014514496.1|88549_90415_-|hypothetical-protein	gnl|CDD|197216	cd09117, PLDc_Bfil_DEXD_like, Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain. Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, uncharacterized type III restriction endonuclease Res subunit, and uncharacterized DNA/RNA helicase superfamily II members. Proteins in this family are found mainly in prokaryotes. They contain one copy of the conserved HKD motif (H-x-K-x(4)-D, where x represents any amino acid residue) in a single polypeptide chain, and have been classified as members of the phospholipase D (PLD, EC 3.1.4.4) superfamily. BfiI consists of two discrete domains with distinct functions: an N-terminal catalytic domain with non-specific nuclease activity and dimerization function that is more closely related to Nuc, an EDTA-resistant nuclease from the phospholipase D (PLD) superfamily; and a C-terminal domain that specifically recognizes its target sequences, 5'-ACTGGG-3'. BfiI forms a functionally active homodimer which has two DNA-binding surfaces located at the C-terminal domains but only one active site, located at the dimer interface between the two N-terminal catalytic domains that contain the two HKD motifs from both subunits. BfiI utilizes a single active site to cut both DNA strands, which represents a novel mechanism for the scission of double-stranded DNA. It uses a histidine residue from the HKD motif in one subunit as the nucleophile for the cleavage of the target phosphodiester bond in both of the anti-parallel DNA strands, while the symmetrically-related histidine residue from the HKD motif of the opposite subunit acts as the proton donor/acceptor during both strand-scission events.	9.42248e-10
NC_017278.1|WP_041433607.1|98268_99429_+|acyl-CoA-dehydrogenase	gnl|CDD|173844	cd01155, ACAD_FadE2, Acyl-CoA dehydrogenases similar to fadE2. FadE2-like Acyl-CoA dehydrogenase (ACAD). Acyl-CoA dehydrogenases (ACAD) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACAD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. ACAD's are generally homotetramers and have an active site glutamate at a conserved position.	1.84896e-98
NC_017278.1|WP_014514489.1|80320_83077_-|hypothetical-protein	gnl|CDD|350769	cd18011, DEXDc_RapA, DEXH-box helicase domain of RapA. In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	1.12452e-60
NC_017278.1|WP_014514505.1|97838_98378_+|MerR-family-transcriptional-regulator	gnl|CDD|133381	cd01106, HTH_TipAL-Mta, Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA. Helix-turn-helix (HTH) TipAL, Mta, and SkgA transcription regulators, and related proteins, N-terminal domain. TipAL regulates resistance to and activation by numerous cyclic thiopeptide antibiotics, such as thiostrepton. Mta is a global transcriptional regulator; the N-terminal DNA-binding domain of Mta interacts directly with the promoters of mta, bmr, blt, and ydfK, and induces transcription of these multidrug-efflux transport genes. SkgA has been shown to control stationary-phase expression of catalase-peroxidase in Caulobacter crescentus. These proteins are comprised of distinct domains that harbor an N-terminal active (DNA-binding) site and a regulatory (effector-binding) site. The conserved N-terminal domain of these transcription regulators contains winged HTH motifs that mediate DNA binding. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. Unique to this family, is a TipAL-like, lineage specific Bacilli subgroup, which has five conserved cysteines in the C-terminus of the protein.	1.23185e-15
NC_017278.1|WP_014514485.1|67601_68693_+|IS4-family-transposase	gnl|CDD|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	2.41744e-09

Protein sequences

>NC_017278.1|WP_014514494.1|86609_87830_+|IS256-family-transposase
MFNRGAHLSTRRCPVDQDTLRILLREAVRETVAEVLQTVLELDRTAFLQVHGGRRNGYYPRKLETTFGQVDLKVPRDRESRYYPAFLKPYVRRLVDVGEVAVALYAAGVSQRKAAEILSLLLGHRYSHETLSALTDEVLEAAGAFRTRPLPEEMAFVYLDGLSLKVFREGEGIVRESVYVALGIAPNGERRVLGFWLLPTESALGWEGVLGELWQRGLRRVLLFITDGLPGLPEAIRRVYPQAEWQRCVVHGVRWSLSQVRARDRGLLAEDLRRVYGAESREEALGALEEVKAAWGSRYPGVVGLWVQDSGAFLRFYGYPKVLWPYLRSTNLMERFIREVRRGTKVRDHKFPKEEAVYKLLYLESERQEGRWAERKLKGFSEVKEVLEKMLQERYAPRTQTLTHNS
>NC_017278.1|WP_014514493.1|84689_86180_-|TROVE-domain-containing-protein
MPLNPGPRVHPTHQGGRGFPASPQGELLLLVAGSLFSGDLFYEGAEEREARFTALAAEVTQQDPEFVALLATYARQVLGLRSGPSALVAHLFWWGPVEVAEGAAQRVWLRGDEHLETLAYTRAQGWRIRKALKRAVAQRLNAMSPQALLKYRWEGRGFRQRDALILCHPKAPDREHALVYEWLVRGREAQPEARALVETLLAERPTWERILSRKGSTPEAWREALPHLSGLALVRNLNNLHRHGLLEDPGVQAWLAQRLGDPRVARWGLFPYQWLQALLQGEELGYPQAVLSALEGALEASLPSLPFQGESLVLVDVSGSMYQPLSARSQATYALAAASLGALLYRATGGQLYGFDRHTIPLPYGPDAPLGQMVRHLLEAGGGGTYLGEALRRTLPAFPGPRVVILTDEQVADDAYTPLRRWLGEDPSRVAHVVNVAGYGPLAFPEGGVSRVAGFSGRLLELLAVLEAQDPKAHLRARVSEASLAEEEEEGEGQGR
>NC_017278.1|WP_014514492.1|84227_84686_-|YbjN-domain-containing-protein
MVQPVEPLTAERIGRALKAMGLKVLVNEDGEFLVLFKKDPSANPMALVNVAPQGSANQVLAVIALVKGHPPMEPEELLAKANEWNGTRRWPRALVRGGELLLDYHVDLEEGVTEAQLRNFLATAFSGIGQFLLWIEGGDDLEDLFRTLGLLG
>NC_017278.1|WP_014514491.1|83941_84211_-|hypothetical-protein
MPIRYNPYTGRYEYAEKDQEPVQNEYEGGYEFGRQRETDYTPFTRRYRKRGEGLVDRWNPYTGRYEAVPEGWEPRQNPYTGEYELGPEE
>NC_017278.1|WP_155983229.1|83121_83916_-|hypothetical-protein
MSLKLVENLSDGRLLVSHQGLEVVVVAPDYQEVREKAEALGYGREVPLVVGHSDSLPKGEPRKIADSKTYEEYILEAALPFVENIGQYCSFERPPMVNLKLYCLHPKPEEKGFEAIGEVRIYSVRTYVPVELRGNKWGLKGEIVAVKGDILGIALVRVYRPSGFWDYTWEILSDAKVLEPAPSLEAVVKLVQRFLKESEDQLEPGNRYKIITYTPARALEMHLIRPLLTPSELARAEHGFFFEATWGNPTPKAEADLFPLKKRD
>NC_017278.1|WP_014514489.1|80320_83077_-|hypothetical-protein
MNVDMLQPGALFRARGRDFRLERRQGDVLVARTVDSEEETLFYLPLEGEALELTTLGLPPERPGDPALHDLLLQALDLATLHADAPFLALQRSRVVPANYQLVPLLMALRQPKVRLLIADDVGLGKTVEAGLIIKELLLRNKARRVLILAPAHLLGQWQEALRRFFHLDFAVLSGPNLKRLARTLPPGANPWAHFDRIIASVDYAKQGDVRQLVLLQDFDLLLVDEAHMAARPPTEKGKQMERYRLVRELARRVPHLLLLTATPHNGYTESFYSLLEHLDALGLGLFKNGTLDREVAKKHVVQRRRKDVEEWFRKEGKKSPFPERETKEEAVNPNRAELELFEAVRRYQAEVYDPDPAKVPVLGRWLAMHLMRRATSSPRALERSLERRKGLLENLLTEGQGITGEEEAALFDTTPDRLLPEEAEVGLELSLADRARAQAEKGYLETLLRYLKGWRKDSKLERLRDLLTQPFLFGKGRTLLFTRYRDTLEYLVEKLGPNLPYPVFAVHGEMSEEDRDEVLKAFAQESPALLIATDVFSEGLNLQHYAAQLIHYDLPWNPNRLEQRNGRIDRFGQPEPRVRIRTFYYEQSFDVAVFHLLLEKAERIRRELGVVPAFFGEEAYLRERLEALWKQDWRQERRLQASLFAEVEDRELEGARRAVQEGFYGHSEFSLPDVEKRLQQALERAGNPKALEGFVLDGLRYLGWRVWGEDPYTAERDAGEAVPGLPARFGPFSFDPEAPLGVEVLDLSHPLVEHLVSYLRYRAYRDLDGARTALLALRAPLGTPPVAFYHFRARFLGPGGEVLETLYRRALRLLDGAEVPPKEAEALWRARLKAAPALSREQAQLLAADALRTPLEALGRRGAEEALARLKAEREALKRDLERAYGTLPEAFRELDRLELLGHELLAITLLAPAALR
>NC_017278.1|WP_014514488.1|76310_80309_-|N-6-DNA-methylase
MFHAIRLSGGIFTEEFLQTLGHPEALKELSLTPEELRNRFYLLLNLYERHKPLYELRDTSRARESWLLPLFRALGFQPVYNRSHLVVGEQAFPISHRGWDGEEAPPLHLVAGELDLRPNRREKSPQGLVQGYLNAHPHQDWGVVAAPWEVRLLRKYYHVSLPGYVAFNLVELFEAPREQALREFQILLLLLSPSRFQKGKDGKTPLERYYETARQTGIRARDALRKGVVEALEILGNAFLNESLRQELNDPERLAAYHAELLRLVYRILFLLYAESRGLIPTGGELSWVYEREYSISALRERAARDNPYGEDRNTDLWEKLLLTFHLVYRGDARLGVPALNGELFAPENLRILTGGVSNPGERARFPELPRPTNSQLLRAIRHLTHLEREGALERINYRDLEVEEIGHVYEGILALTPRLVEGRYSLESHLLDKKLSGSYYTPRELVQLVVQEALAPVVEERLKAAGDDPERQEEAILSIKVVDPAMGSGAFLISALEYLAEKLLEVRGQSKGDPEALYAARHLVATRCLYGVDLNPMAVELAKLSLWVASADRSKPLSFLDHHLKVGNSLVGAPQDFLEKGIPKEAYDREDIPKEVRKSLRFGPGGGTLLFAPPSPPFLDFEEESAEQVEEKRRRYQAWRESEEVRKMELFADYWTAAFFLRPAPGVRLPDAEGLNWLAQQSRASLEQLGQSSYLNPPTLAAIQVAKRRHRFFHWWLEFPEVFRAGGFDVVLGNPPWEVMEPKEEEFFAERAPHIAALPGKKRKETIEKLSQTDPDLFEKWKEHIRSISTTVQFARNSNRFPLTSKGDANTYRYFAELAYRLRSPRGRVGLIVPTGIATDDSNKEFFAHLVEKGEVSTLLDFENRERLFPGIDSRIKFAVLALRPPSPEPARLAFFLTQPDQAQDPVRQFRLAPRDFALLNPNTRTCPVFRTRQDAELTRAIYEKVPVLWREEPEENPWNVRFRQGLFNMTSDSHLFHTRADLEAQGFHLEGNRFLRGKEIYLPLYEAKLIWHYDHRFATYDGEDTRETTLGEHQDPAYLPLPRYWVRAEEVEGRLEGRGQRGKEAWRWGRGWLLGFRDVTNATNERTVIFSFIPRIAVGHTVPLIQSTYSAVLQLALLSSFNNLVLDFLARQKVGGTHLTFHLLKQFPVLPPSTYGPQDLLFIVPRVLELTYTAWDLAPLAQEVWQEASPELRQALLAQHQANGGHPDAPPPWVQGPYPFPPFRFDEGRRALLRAELDAYYARLYGLNRKQLRYILDPQDLTPKELADILSDIEEVADPLDEREYRKRRERSSFPGETFRVLRDKEEKRYGEYRTRRLVLEAWTKLHTKG
>NC_017278.1|WP_014514487.1|74308_76306_-|hypothetical-protein
MNPSTKSTLYVNLFPLKRSPQEGRIFRFAHRDPQSFLKYLQAIGWIAQKRGDEVWIFALERPEVRAPFVGEAEPTSLQERAMAFNSHLNRLLSQKGFYRTGSRWIDPEEWTRIEGVFLSGPFQGKAFPVRQHQAYKVEVVNLLGTFYALVDLSKQLLSDAPLEALSVELVTYLEAQAPKHPLHALDLHTGKRTFWETADPRGHLLLHPVHLEELGVVGEQGQMRRTSQEAFERSQFNFAHLLEKITLFSEVLVPEPLALSEEVLGRIEGLGLRMAKGLAAEPKEVRFKGFLYAPSKISLRPILPDTPEVAFTQKVTKKPSFHVETKRRGKPPQRSGHLEHKVTVGISPRHLLLYHLVEPHRLKNSREGLEILQRFGHAKGHAKDGYSLVQALKQFGTSIQVAQPSLRYDPTTGEIQGSPNPGSSGENEVNFILAPPEVGRYALGRLLKQLKKYFPKAANQVVNPDTLGSPTKVLSLAYDLLVGKFRTTVPYALKDLGQHVLGLRATQEDGFLWRLIGPEGFVLGKGKGFPPEEILPRAFVVHFMGNDRQLEEVMDWTHEPVVRLELSDLRFSQKNLPLGTFFRATPEVAYLLAHPGYPGWPTALRVEVIQGNLTLEEALKQVYWLTKPTGGLYHPGKLPLSVEEKVPWDRLQPPREMGQTYSLER
>NC_017278.1|WP_014514486.1|68709_74256_-|DEAD/DEAH-box-helicase
MGLALRPEDLRPERWFSQVLPRVVQGESLDWSAVPDAHPQDLEGLLQPLFHLNLSPEELSRRLGLASMAEALRSWVASRMGLPLVRLAERGSVRDPFRQLEAIQNSFRGYAESFVNPRNPAIADLLRQGIEEEDLLWREPFVAQKRRYRLGKSLEALIQEGLLPPSIRPLLRKNPEDLQDPTPFHPYLHQEEALRAALAGESFVVATGTGSGKSLAFGMPIFAYALTAKRPGIKAVIVYPMNALANSQYRDFALRLHGSGLRIALYNGETPYTKQDGQALRERLLQERFVSDAEVLSREEIRQDPPDILMTNYVQLELLLTRGEDRTLFPPEHRGVLRYLVLDEVHTYAGLRGADVAFLIRRLKQHTGTTETLQVIGTSATVDRGVEAIRRFAENLFGTSVARVIGEHLEEPPPLDLSHLPEELREALSARPDGETRVRRALVFLEKALEEPHTLSELAKKLSHEEGISQDQARAEVALALRVGAATGYLVPRIHAFYAQAPDLTATLDLEGLSLKGEKHLHGKPAYPVVFCRNCGQEYLIAREEKGQFLPGPSFLELFRGEIRYLRPGAWVPDREPLPESWLDESGEVKRDRRRLLPQNRVLDPYTGTPAEEGVPVAILPFPFQFCPTCQVSYTRQGNEIRKLAAFGLVGRSTATDLLLLSTLGTFPREEQKIIVFTDNRQDAEFQAGHFQDLFRKVLFRQTVMEILAQGPAYLSELGGQVYQAWARSDPRAEMRPLYEEHAPEGVAFRDLLSLVAVLEAGRNTQPNLKNLEAAGLIRYRYRHLEELLQDRGIWEGLSVPEEVLRDYLTGLLDLMRRRGAIFHELLNPISFRFRVEEKLFAFVHEVFAEPMGGSILLEVRASQAPRFGQTLRLYGDRRRPSLFEQWTMGALNLPWEEAAARLRRVVRALKDRRVLVAWELPSWGRNKVSGLALNPSAILLEKTGGDYLLCPRSGYTGPLYALRISPEYPSQALEERRVHPFYETLYEKRRFPLPLEARAHSAQVSGEERRRLEERFRNPEDPLSVLVATPTLEMGIDIGALSSVFLRNIPPSPANYAQRSGRAGRKGQPALIQAFAGAMGHDQYFYRFPERMVRGSVQAPRFLLDNPRLVKAHLRALVLEILAQWGFSLPGKVGEAVDYEDHTHLYPLRAGFRAALEQGISTHQGAILQAVGEAFRREMASFPWFTQEVVRSTVEGFVAELDAELNSWREEYHDAQARYTEFMTRLQHMGPRHPNREEIQAEATRADKQRRYLVDLDLRGYLAARGFLPNYAFGRVTTWAELITPGGEVERLERPSFIALTEFAPGNSVYFGARRYRLDRLAVLPKEEAFRTAKRCTCGHVEAQGDRCRACGKDLSATLPNVRLLAPPILTGLPRRRITSEEEDRVRMGYEVEWDWRPKAPRALQGGSFRLLYEHNAEVVAMNKGLRAWLLDEEEENPLQEGFVYCQRCRRFLLTGKELEEHPWREDREGRCPVGGKPEDLKRGIVLEARAESDVLALEVPAPLGIGDGERLSFYKSLLAAFRKAALVVLELAEDELFGFLQPISNPQVPYRVVLVEGQEGGLGALAALAEWPSREESHPLQELARTALRLMHHGEEKACERACYDCLMDYSNQVDHALLDRRLVQDFFTELQSTVFEDLPAPSRLQELQARCQSELERRWLQACHERGLPLPDEVQYTYALGDTYTRFDFFYARGLGIYVDGPPHLDPRRQEQDREIRRRLTLLGVPFLVFREGEDWEKGFEELGLHLGRRGGGLSWEEALALVLPGYRPLLEALRKAGFPPPDEVGEDLVVEGRVVGQSVARWGEKHLVPEGLEGLGLVVRPYTTPDEVLGYLRGEGLASSKEHP
>NC_017278.1|WP_014514485.1|67601_68693_+|IS4-family-transposase
MEQLTPLINALKRYWKADLRRLTFLAALVMALVTARTTSGPRLALSLGSIASPDPRSAYRRFQRFLAWPGLDGEGYARFIFALLRPQGLLLVMDRTEWELGKSKVNLLMLAFLYQGLAVPLFWSFLPHDGNSSTPERIALMERALAFLRAHFPHLRVEGFLADREFIGEAWFRYLEEKGIPRCIRIKANTRMWRLGSGPRAWELFASLKVGESRVPRRRYWVYGRRMWVVGLRLGVREWLIVATDLDPHRVLEVYGLRWGIERLFGALKGRGFDLEATHVTRGERLSRLLVPLSLAFVWAFRTGLVLHRVRPVRPKKHGRLGQSLFRAGLDLLTLWALALWGAGGGRRGSPLGLCPMEVLTCT
>NC_017278.1|WP_014514496.1|88549_90415_-|hypothetical-protein
MDREMPSTPLFSEPLRERLGIVFSLDEGRALECSPMELLLGYTKLRAISFSASLKGLAELLAPLEEVELLLGLEEGHAAASALAALWEEAQSLLVLMGTKRRLEVRFLPNSHAKLYLLEGPKGVRTILGSLNLSQSAWSGVQGEIAAFSDRLEVYQAFLSWYEGERERARPLLGERERKRLEGKSLLLMPTALPPEEVRRAVAEAKGIVVVNLLPHKPLVDRTEREKEAELRALKELTWEMRKAEDLVRLRGKETYLQSLVERALREVPVLEYAPDGPRYRGLLAKDLSPDPQGVEATLRALSALLEGARRGSPSLAEAVGEALVYGFASSYLPLLREEAGRQGRSPTRFPIVALLVGRAGAGKTTILRAIAATWGISFRHYRQVEETGRSKGATVEAHLYLEERAPLPIDEVPPRHLTEENRLAQVVKGVGDDPGVRRALILTSNLEHFRSEEQILRRAWFIPFEHLPQGMGSADLEDHLKAIRPDLFLRFLQEAFPTSDELASLLQGNDPLAPARRFLRGMGLSVPEGPKGDYRAHLLARWRNLYHTQREIFREIQAPDIATGRPIPCFVVDKEKAGFLVPLQAFDNGFSGNGQAFLLKKREFLEAIGEGRPWWRRVWG
>NC_017278.1|WP_014514498.1|91294_91981_-|ABC-transporter-ATP-binding-protein
MSLRLEGFRAGYGGIPVLHGLDLEVREGEVVALLGRNGAGKTTTLKGIMGLVRSQGGRVVYRDQDLARMPPFLRAQLGLGYVPDDRRIFPELTVRENLLIAHRPGPWTLDRVYGLLPRLQEIENRRGGLLSGGEQQMLTLARTLMTNPRFLLLDEPTEGLAPLIVEEIARLLLELKREGMPILLAEQNLRFTGRVADRAYVLETGEIRLSGPMGELMHREEVAALLSL
>NC_017278.1|WP_041433604.1|91977_92724_-|ABC-transporter-ATP-binding-protein
MGLLEVEGVYKSFGGFLALASVSLSVAEGTFHALVGPNGAGKTTLFNVITGRIRPDAGRVRFRGEEITGWPTSRVARKGIAISFQRAQPFSSFTVLEAVVLARLGYEGRTFTLQPLKAFPGAWEQAREALVKVGLGGYAHRPVSELPLGDLKRLDVAIALVARPKLLLLDEPLAGLSRAERKQMVEFIRGLLRQEGITLLFTEHDTEAVLALADRITVLHQGQVLAEGTPEEIQKDQKVRQAFLGGGA
>NC_017278.1|WP_014514500.1|92704_93637_-|branched-chain-amino-acid-ABC-transporter-permease
MRLGLLVLCLALLGPFLGEYGLKLLSEALILGLYAMAFNLLFHQAGLLSFGQAAFFGVGAYAMALLMARSGWSFLATLPLAFLLGGAAAFLVGFLSLRLTRIYFTMLTLAFAQLLYAVAHKWYAFTGGDNGITDLRPAGPWGESLPFYYLTLGLFGLLVGLLASLERSPFGYALRALRDNRARAEAVGLDGFRHLLLAFALAGAISGVAGALQGALQRSVFPDYLFWTRSAEAIISTILGGSGVFLGPAVGAAAFLFLRVLVQAQTEYWPFFLGLLLLLMVLFFPRGLAGVWARLGRGISLGVERGAPRG
>NC_017278.1|WP_014514501.1|93633_94515_-|branched-chain-amino-acid-ABC-transporter-permease
MDLSFLLLQLLTGLAYASTLFLLSVGLSLIFGAMGIVNFAHGSFYMLGAYLLFAFTRGQAEGFWAGLFLVLAAGLVVGALVERLLIRPIYPRPEEYQILLTYALLLILEDLVRLAFGAGYRSFPLPPLFSSPLFLLGAPFPSYYLFLLALAGLSALGLWAFLYRTRLGTWVRAATQDREMLEALGVNVPLLYTAIFALGIALAALGGAALVPLQAATPGMAVDAVINAFIVVVIGGLGSVWGALLGAVLIGLLQAFGILLLPEMAMVFPFALMALVLLLRPWGLLGRPPAVRT
>NC_017278.1|WP_014514502.1|94518_95715_-|ABC-transporter-substrate-binding-protein
MKAWRWILAFGLLAGLVLAQGQQPIKIGALFILSGNFAGYGKSGSQGAQLAVEEINARGGVLGRPLQLLVVDDQGNPEVGVREARRLVLQEKVDFLFGIDSSSVALAVAPLTDEYKIPLVVTHAATPTLTEQCRPYVFRTSNNARMDAWAAAALAATLPVKRWANIGPDYEFGRVSWQDFIARLRQLRPDVEVVSEQWPRFGSTDYASFITALMRARPEGVFSTLWAGDMVIFARQAKAFGFFNQVRYFVNPVGAALEVLAPLGKETPEGLLVSARYWFLYPNAERNRAFVEAYRKRFGEYPSYNAQEAYAGMQMLALAIQKARSTQAEAIRKAFEADGGLVYEAPEGRKRMRPEDHQVFESLVWGYTKHSPEYPFAILERMRIVPASDTVYPTQCKR
>NC_017278.1|WP_041433606.1|95725_96457_-|SDR-family-oxidoreductase
MPRLEGRPVLVIGATRGIGLAVAQELARRGARLGLTGRDPERVRAVATELGAWGKAVDVRRREDLVEAVAGFARDVGLYGLVYNAGTSPAFTRAERLSLEVWDEVLAVNLTGAFVAAQAFAQRLVGEGSVVLVGSVLGFRGGGRLAAYTASKAGLWGLTRALALDWAERGIRVNLVAPGWTETEMTQGLREHPHLGPALLREIPLGRMARPEEVARMVAFLLEPENAYLTGGFYAVDGGVGAR
>NC_017278.1|WP_014514504.1|96443_97736_-|AMP-binding-protein
MRAFWEPEVETLPRPQLESLQLERLRQQVERLWRTSAFFREKWAGVNLELRHLEDLSRLPLVTKAELRAEQQAHPPLGRYTGVEAQSWREYHPSSGTTGFPVGTVWSEGDVENITQVTARVLYGYGLRPGDILLNGFSYGLWVAGLAVHYAARAMGLFVLPVGAGQTERHLELMERFRPRALTATPSFGLYLGEALRARGLESPLRIGAFGGEAGTENPSTRRRLEEALSLQAYDFYGLAEMGPTFAGECQAKAGLHFAEDHYLVEVVDPESQEPLPEGEVGVLVLTHLTREATPLVRYYTGDLARLTKEPCPCGRTHLRAVGGILGRVDDLVVYRGAKFYPGQVEEVVRRFPELAGEYRIEVWEAGGLVQGVTVVVEMAHPGVGEGLVEALRQSLKAALGVTPEVRLEAPGTLERTAFKAKRVVRHAQA
>NC_017278.1|WP_014514505.1|97838_98378_+|MerR-family-transcriptional-regulator
MAQSTIPSLYTLSDLARESGVSRRILQHYAHLGLLEPGALTQGGRKLYTGFALYLIQDIQDLNQLGFTLEEIRKIMALKKVIFHPDGTYREDWRREEIPLTQEELWAMWAKTGEVLSSMERQERMIRRFHRFLTKHFAPKEVRDGLRSGPGDGGAQGAGAGLPGGGGDPQGGGGGQEPG
>NC_017278.1|WP_041433607.1|98268_99429_+|acyl-CoA-dehydrogenase
MDFGLDRETEALKERVRAFLEEAVIPREGEAARNLDSLEAIAKELQGEAKRRGLFLPHMPKALGGLGLTWTQLAVVLEEAGRSLLGPKALNASAPDEGNMHLLEKVGSEAQKRRYLHPLLEGEIRSAFAMTEPMGAGADPSLLKATARRKGRGFVLEGRKWFITGAEGAAFFIVLARAEEGPTLFLVDRENPGLKLVRTIPTMDHWSIGGHGELVLEGCEVGEEAVLGEVGQGFAYAELRLDPARLTHCMRWLGVGVRATELAQAYALQRDSFGKKLAEHQGVQFMIADSHMELHAARLMVWHAAWKLDRGERIRHEASMAKVFVAEAVGRAVDRAVQITGGLGISEDIPLSIFYREVRPFRIYDGPSEVHRASIGKRALYKGLRP

Crispr_ID: NC_017278_2

• CRISPR_ID: NC_017278_2
• CRISPR_location: 256084-257261
• CRISPR_type: TypeIII
• Repeat_type: NA
• Spacer_info: 17 spacers
• Cas_protein_info: cas10,cmr3gr5,cmr1gr7,cmr4gr7,cmr5gr11,cmr6gr7,cas1,cas3,cas6,cas8b1,cas7,cas5,cas2

Consensus repeat of NC_017278_2

Consensus_repeat	Method
GTTTCAAACCCTCATAGGTACGGTCAGAAC	PILER-CR
GTTTCAAACCCTCATAGGTACGGTCAGAAC	CRISPRCasFinder
GTTTCAAACCCTCATAGGTACGGTCAGAAC	CRT

spacers of NC_017278_2

>2.1|256114|39|NC_017278|PILER-CR,CRISPRCasFinder,CRT
TCGGGTTCCTGGACGGGCATACTTCACCCCCATCCTGTC
>2.2|256183|36|NC_017278|PILER-CR,CRISPRCasFinder,CRT
CAACGGACACTACCTTGCCGACGCCCTGGAAGCAGG
>2.3|256249|38|NC_017278|PILER-CR,CRISPRCasFinder,CRT
GAAAGGGGGCGGTACATGGTGTCGCCGTACCTAGCCGC
>2.4|256317|39|NC_017278|PILER-CR,CRISPRCasFinder,CRT
CCTCCGGAGGCTCGCCAGCCTCCGCCCCACTATTTCGGG
>2.5|256386|41|NC_017278|PILER-CR,CRISPRCasFinder,CRT
CTGCGGGACTTCCACACCACCCCCCGGTCCAAGAGCCGCCC
>2.6|256457|39|NC_017278|PILER-CR,CRISPRCasFinder,CRT
GGCTAGGGCGGCCATAGTTTTGGGGGCGGGCTCAGTGCC
>2.7|256526|35|NC_017278|PILER-CR,CRISPRCasFinder,CRT
AAGGCCCCCAAGGCCAAGGCGGCCCCGGGGGAGGT
>2.8|256591|36|NC_017278|PILER-CR,CRISPRCasFinder,CRT
CTTTCAATGAAAATAAAGCTAGATTTGCATTAAGGT
>2.9|256657|37|NC_017278|PILER-CR,CRISPRCasFinder,CRT
AAGCGTGCGTTTACCCATATGATATCAGCTTTTGCCT
>2.10|256724|35|NC_017278|PILER-CR,CRISPRCasFinder,CRT
ATGTTGAAGCATGCTATCCAAAGCATGCTTCAGTA
>2.11|256789|39|NC_017278|PILER-CR,CRISPRCasFinder,CRT
GGGGGGCTTGCGCTAGGTGGCCCTCATGGGCGATAAAGG
>2.12|256858|36|NC_017278|PILER-CR,CRISPRCasFinder,CRT
CAGAGCAGTCCCGTAGCCTATGGCCGCATACCGAAG
>2.13|256924|39|NC_017278|PILER-CR,CRISPRCasFinder,CRT
GGGGGCGGCCAAGGCCGAGGCCGAGGCCCCCAAGGCGGT
>2.14|256993|36|NC_017278|PILER-CR,CRISPRCasFinder,CRT
CGCCACGAACTCTATTGGAAACGAACTTTTTGAGGG
>2.15|257059|37|NC_017278|PILER-CR,CRISPRCasFinder,CRT
GAGGGTCATGATGATTGAGAAGATTTGGGGCATGCTC
>2.16|257126|38|NC_017278|PILER-CR,CRISPRCasFinder,CRT
AGGGTGGCGGTAGCAGCTTGGGGGTCCATGGCCTCCAC
>2.17|257194|38|NC_017278|PILER-CR,CRISPRCasFinder,CRT
GAATAGCCTGCTGGAGTACCAAGAAGATGCGGTTACCG

CRISPR arrays and Neighbor proteins around NC_017278_2

CRISPR arrays

The CRISPR arrays of NC_017278_2

>merge|NC_017278|2|256084-257261|PILER-CR,CRISPRCasFinder,CRT
GTTTCAAACCCTCATAGGTACGGTCAGAACTCGGGTTCCTGGACGGGCATACTTCACCCCCATCCTGTCGTTTCAAACCCTCATAGGTACGGTCAGAACCAACGGACACTACCTTGCCGACGCCCTGGAAGCAGGGTTTCAAACCCTCATAGGTACGGTCAGAACGAAAGGGGGCGGTACATGGTGTCGCCGTACCTAGCCGCGTTTCAAACCCTCATAGGTACGGTCAGAACCCTCCGGAGGCTCGCCAGCCTCCGCCCCACTATTTCGGGGTTTCAAACCCTCATAGGTACGGTCAGAACCTGCGGGACTTCCACACCACCCCCCGGTCCAAGAGCCGCCCGTTTCAAACCCTCATAGGTACGGTCAGAACGGCTAGGGCGGCCATAGTTTTGGGGGCGGGCTCAGTGCCGTTTCAAACCCTCATAGGTACGGTCAGAACAAGGCCCCCAAGGCCAAGGCGGCCCCGGGGGAGGTGTTTCAAACCCTCATAGGTACGGTCAGAACCTTTCAATGAAAATAAAGCTAGATTTGCATTAAGGTGTTTCAAACCCTCATAGGTACGGTCAGAACAAGCGTGCGTTTACCCATATGATATCAGCTTTTGCCTGTTTCAAACCCTCATAGGTACGGTCAGAACATGTTGAAGCATGCTATCCAAAGCATGCTTCAGTAGTTTCAAACCCTCATAGGTACGGTCAGAACGGGGGGCTTGCGCTAGGTGGCCCTCATGGGCGATAAAGGGTTTCAAACCCTCATAGGTACGGTCAGAACCAGAGCAGTCCCGTAGCCTATGGCCGCATACCGAAGGTTTCAAACCCTCATAGGTACGGTCAGAACGGGGGCGGCCAAGGCCGAGGCCGAGGCCCCCAAGGCGGTGTTTCAAACCCTCATAGGTACGGTCAGAACCGCCACGAACTCTATTGGAAACGAACTTTTTGAGGGGTTTCAAACCCTCATAGGTACGGTCAGAACGAGGGTCATGATGATTGAGAAGATTTGGGGCATGCTCGTTTCAAACCCTCATAGGTACGGTCAGAACAGGGTGGCGGTAGCAGCTTGGGGGTCCATGGCCTCCACGTTTCAAACCCTCATAGGTACGGTCAGAACGAATAGCCTGCTGGAGTACCAAGAAGATGCGGTTACCGGTTTCAAACCCTCATAGGTACGGTCAGAAC

>NC_017278|2|2|256084-257261|PILER-CR
GTTTCAAACCCTCATAGGTACGGTCAGAAC	TCGGGTTCCTGGACGGGCATACTTCACCCCCATCCTGTC
GTTTCAAACCCTCATAGGTACGGTCAGAAC	CAACGGACACTACCTTGCCGACGCCCTGGAAGCAGG
GTTTCAAACCCTCATAGGTACGGTCAGAAC	GAAAGGGGGCGGTACATGGTGTCGCCGTACCTAGCCGC
GTTTCAAACCCTCATAGGTACGGTCAGAAC	CCTCCGGAGGCTCGCCAGCCTCCGCCCCACTATTTCGGG
GTTTCAAACCCTCATAGGTACGGTCAGAAC	CTGCGGGACTTCCACACCACCCCCCGGTCCAAGAGCCGCCC
GTTTCAAACCCTCATAGGTACGGTCAGAAC	GGCTAGGGCGGCCATAGTTTTGGGGGCGGGCTCAGTGCC
GTTTCAAACCCTCATAGGTACGGTCAGAAC	AAGGCCCCCAAGGCCAAGGCGGCCCCGGGGGAGGT
GTTTCAAACCCTCATAGGTACGGTCAGAAC	CTTTCAATGAAAATAAAGCTAGATTTGCATTAAGGT
GTTTCAAACCCTCATAGGTACGGTCAGAAC	AAGCGTGCGTTTACCCATATGATATCAGCTTTTGCCT
GTTTCAAACCCTCATAGGTACGGTCAGAAC	ATGTTGAAGCATGCTATCCAAAGCATGCTTCAGTA
GTTTCAAACCCTCATAGGTACGGTCAGAAC	GGGGGGCTTGCGCTAGGTGGCCCTCATGGGCGATAAAGG
GTTTCAAACCCTCATAGGTACGGTCAGAAC	CAGAGCAGTCCCGTAGCCTATGGCCGCATACCGAAG
GTTTCAAACCCTCATAGGTACGGTCAGAAC	GGGGGCGGCCAAGGCCGAGGCCGAGGCCCCCAAGGCGGT
GTTTCAAACCCTCATAGGTACGGTCAGAAC	CGCCACGAACTCTATTGGAAACGAACTTTTTGAGGG
GTTTCAAACCCTCATAGGTACGGTCAGAAC	GAGGGTCATGATGATTGAGAAGATTTGGGGCATGCTC
GTTTCAAACCCTCATAGGTACGGTCAGAAC	AGGGTGGCGGTAGCAGCTTGGGGGTCCATGGCCTCCAC
GTTTCAAACCCTCATAGGTACGGTCAGAAC	GAATAGCCTGCTGGAGTACCAAGAAGATGCGGTTACCG
GTTTCAAACCCTCATAGGTACGGTCAGAAC

>NC_017278|2|2|256084-257261|CRISPRCasFinder
GTTTCAAACCCTCATAGGTACGGTCAGAAC	TCGGGTTCCTGGACGGGCATACTTCACCCCCATCCTGTC
GTTTCAAACCCTCATAGGTACGGTCAGAAC	CAACGGACACTACCTTGCCGACGCCCTGGAAGCAGG
GTTTCAAACCCTCATAGGTACGGTCAGAAC	GAAAGGGGGCGGTACATGGTGTCGCCGTACCTAGCCGC
GTTTCAAACCCTCATAGGTACGGTCAGAAC	CCTCCGGAGGCTCGCCAGCCTCCGCCCCACTATTTCGGG
GTTTCAAACCCTCATAGGTACGGTCAGAAC	CTGCGGGACTTCCACACCACCCCCCGGTCCAAGAGCCGCCC
GTTTCAAACCCTCATAGGTACGGTCAGAAC	GGCTAGGGCGGCCATAGTTTTGGGGGCGGGCTCAGTGCC
GTTTCAAACCCTCATAGGTACGGTCAGAAC	AAGGCCCCCAAGGCCAAGGCGGCCCCGGGGGAGGT
GTTTCAAACCCTCATAGGTACGGTCAGAAC	CTTTCAATGAAAATAAAGCTAGATTTGCATTAAGGT
GTTTCAAACCCTCATAGGTACGGTCAGAAC	AAGCGTGCGTTTACCCATATGATATCAGCTTTTGCCT
GTTTCAAACCCTCATAGGTACGGTCAGAAC	ATGTTGAAGCATGCTATCCAAAGCATGCTTCAGTA
GTTTCAAACCCTCATAGGTACGGTCAGAAC	GGGGGGCTTGCGCTAGGTGGCCCTCATGGGCGATAAAGG
GTTTCAAACCCTCATAGGTACGGTCAGAAC	CAGAGCAGTCCCGTAGCCTATGGCCGCATACCGAAG
GTTTCAAACCCTCATAGGTACGGTCAGAAC	GGGGGCGGCCAAGGCCGAGGCCGAGGCCCCCAAGGCGGT
GTTTCAAACCCTCATAGGTACGGTCAGAAC	CGCCACGAACTCTATTGGAAACGAACTTTTTGAGGG
GTTTCAAACCCTCATAGGTACGGTCAGAAC	GAGGGTCATGATGATTGAGAAGATTTGGGGCATGCTC
GTTTCAAACCCTCATAGGTACGGTCAGAAC	AGGGTGGCGGTAGCAGCTTGGGGGTCCATGGCCTCCAC
GTTTCAAACCCTCATAGGTACGGTCAGAAC	GAATAGCCTGCTGGAGTACCAAGAAGATGCGGTTACCG
GTTTCAAACCCTCATAGGTACGGTCAGAAC

>NC_017278|2|2|256084-257261|CRT
GTTTCAAACCCTCATAGGTACGGTCAGAAC	TCGGGTTCCTGGACGGGCATACTTCACCCCCATCCTGTC
GTTTCAAACCCTCATAGGTACGGTCAGAAC	CAACGGACACTACCTTGCCGACGCCCTGGAAGCAGG
GTTTCAAACCCTCATAGGTACGGTCAGAAC	GAAAGGGGGCGGTACATGGTGTCGCCGTACCTAGCCGC
GTTTCAAACCCTCATAGGTACGGTCAGAAC	CCTCCGGAGGCTCGCCAGCCTCCGCCCCACTATTTCGGG
GTTTCAAACCCTCATAGGTACGGTCAGAAC	CTGCGGGACTTCCACACCACCCCCCGGTCCAAGAGCCGCCC
GTTTCAAACCCTCATAGGTACGGTCAGAAC	GGCTAGGGCGGCCATAGTTTTGGGGGCGGGCTCAGTGCC
GTTTCAAACCCTCATAGGTACGGTCAGAAC	AAGGCCCCCAAGGCCAAGGCGGCCCCGGGGGAGGT
GTTTCAAACCCTCATAGGTACGGTCAGAAC	CTTTCAATGAAAATAAAGCTAGATTTGCATTAAGGT
GTTTCAAACCCTCATAGGTACGGTCAGAAC	AAGCGTGCGTTTACCCATATGATATCAGCTTTTGCCT
GTTTCAAACCCTCATAGGTACGGTCAGAAC	ATGTTGAAGCATGCTATCCAAAGCATGCTTCAGTA
GTTTCAAACCCTCATAGGTACGGTCAGAAC	GGGGGGCTTGCGCTAGGTGGCCCTCATGGGCGATAAAGG
GTTTCAAACCCTCATAGGTACGGTCAGAAC	CAGAGCAGTCCCGTAGCCTATGGCCGCATACCGAAG
GTTTCAAACCCTCATAGGTACGGTCAGAAC	GGGGGCGGCCAAGGCCGAGGCCGAGGCCCCCAAGGCGGT
GTTTCAAACCCTCATAGGTACGGTCAGAAC	CGCCACGAACTCTATTGGAAACGAACTTTTTGAGGG
GTTTCAAACCCTCATAGGTACGGTCAGAAC	GAGGGTCATGATGATTGAGAAGATTTGGGGCATGCTC
GTTTCAAACCCTCATAGGTACGGTCAGAAC	AGGGTGGCGGTAGCAGCTTGGGGGTCCATGGCCTCCAC
GTTTCAAACCCTCATAGGTACGGTCAGAAC	GAATAGCCTGCTGGAGTACCAAGAAGATGCGGTTACCG
GTTTCAAACCCTCATAGGTACGGTCAGAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_017278.1|WP_014514649.1|255827_256067_-|hypothetical-protein	unknown	unknown	gnl|CDD|378236
NC_017278.1|WP_155983240.1|265468_265717_+|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|187856
NC_017278.1|WP_014514661.1|273177_275055_-|DUF262-domain-containing-protein	unknown	unknown	gnl|CDD|377008
NC_017278.1|WP_014514485.1|271714_272806_+|IS4-family-transposase	unknown	unknown	gnl|CDD|376573
NC_017278.1|WP_014514647.1|252907_254017_-|CRISPR-associated-protein-Cmr3	cmr3gr5	cd09748_cmr3gr5_CAS-III-B	gnl|CDD|187879
NC_017278.1|WP_014514643.1|249427_250450_-|type-III-B-CRISPR-module-RAMP-protein-Cmr6	cmr6gr7	COG1604_cmr6gr7_CAS-III-B	gnl|CDD|213662
NC_017278.1|WP_014514494.1|270255_271476_+|IS256-family-transposase	unknown	unknown	gnl|CDD|307151
NC_017278.1|WP_155983239.1|261919_263791_+|hypothetical-protein	cas8b1	pfam09484_cas8b1_CAS-I-B	gnl|CDD|378190
NC_017278.1|WP_014514638.1|244772_246092_+|cobyrinate-a,c-diamide-synthase	unknown	unknown	gnl|CDD|234896
NC_017278.1|WP_155983238.1|247484_249431_+|hypothetical-protein	unknown	unknown	unknown
NC_017278.1|WP_014514656.1|263780_264740_+|type-I-B-CRISPR-associated-protein-Cas7/Csh2	cas7	cd09690_cas7_CAS-I-B	gnl|CDD|187821
NC_017278.1|WP_014514648.1|254006_255779_-|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	cas10	cls000742_cas10_CAS-III	gnl|CDD|274208
NC_017278.1|WP_014514645.1|250800_251664_-|type-III-B-CRISPR-module-RAMP-protein-Cmr4	cmr4gr7	cd09682_cmr4gr7_CAS-III-B	gnl|CDD|274210
NC_017278.1|WP_014514650.1|257447_258431_-|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl|CDD|187853
NC_017278.1|WP_014514653.1|258920_261158_-|CRISPR-associated-endonuclease-Cas3''	cas3	COG1203_cas3_CAS-I	gnl|CDD|224124
NC_017278.1|WP_155983237.1|246083_246497_-|hypothetical-protein	unknown	unknown	unknown
NC_017278.1|WP_014514646.1|251660_252911_-|type-III-B-CRISPR-module-RAMP-protein-Cmr1	cmr1gr7	COG1367_cmr1gr7_CAS-III-B	gnl|CDD|224286
NC_017278.1|WP_081477220.1|264757_265453_+|CRISPR-associated-protein-Cas5	cas5	mkCas0191_cas5_CAS-I-B	gnl|CDD|187823
NC_017278.1|WP_014514644.1|250452_250797_-|type-III-B-CRISPR-module-associated-protein-Cmr5	cmr5gr11	cd09749_cmr5gr11_CAS-III-B	gnl|CDD|378242
NC_017278.1|WP_014514654.1|261200_261923_+|CRISPR-associated-endoribonuclease-Cas6	cas6	pfam01881_cas6_CAS-I:CAS-III	gnl|CDD|187783

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_017278.1|WP_155983240.1|265468_265717_+|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	5.8e-23	75.7	0.0
NC_017278.1|WP_014514647.1|252907_254017_-|CRISPR-associated-protein-Cmr3	cmr3gr5	cd09748_cmr3gr5_CAS-III-B	3.1e-92	304.4	5.8
NC_017278.1|WP_014514643.1|249427_250450_-|type-III-B-CRISPR-module-RAMP-protein-Cmr6	cmr6gr7	COG1604_cmr6gr7_CAS-III-B	2.1e-49	163.1	0.0
NC_017278.1|WP_155983239.1|261919_263791_+|hypothetical-protein	cas8b1	pfam09484_cas8b1_CAS-I-B	2.9e-49	162.9	0.0
NC_017278.1|WP_014514650.1|257447_258431_-|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	3.8e-127	418.6	0.0
NC_017278.1|WP_014514646.1|251660_252911_-|type-III-B-CRISPR-module-RAMP-protein-Cmr1	cmr1gr7	COG1367_cmr1gr7_CAS-III-B	4e-32	106.4	0.0
NC_017278.1|WP_014514656.1|263780_264740_+|type-I-B-CRISPR-associated-protein-Cas7/Csh2	cas7	cd09690_cas7_CAS-I-B	2.6e-64	212.0	0.0
NC_017278.1|WP_014514648.1|254006_255779_-|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	cas10	cls000742_cas10_CAS-III	2.5e-105	347.9	0.0
NC_017278.1|WP_014514645.1|250800_251664_-|type-III-B-CRISPR-module-RAMP-protein-Cmr4	cmr4gr7	cd09682_cmr4gr7_CAS-III-B	4.4e-84	277.1	0.0
NC_017278.1|WP_014514654.1|261200_261923_+|CRISPR-associated-endoribonuclease-Cas6	cas6	pfam01881_cas6_CAS-I:CAS-III	3e-24	80.9	0.0
NC_017278.1|WP_014514653.1|258920_261158_-|CRISPR-associated-endonuclease-Cas3''	cas3	COG1203_cas3_CAS-I	5.8e-48	158.4	0.0
NC_017278.1|WP_081477220.1|264757_265453_+|CRISPR-associated-protein-Cas5	cas5	mkCas0191_cas5_CAS-I-B	1.3e-105	346.1	3.7
NC_017278.1|WP_014514644.1|250452_250797_-|type-III-B-CRISPR-module-associated-protein-Cmr5	cmr5gr11	cd09749_cmr5gr11_CAS-III-B	5.1e-30	99.1	2.3

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_017278.1|WP_014514649.1|255827_256067_-|hypothetical-protein	gnl|CDD|378236	pfam09670, Cas_Cas02710, CRISPR-associated protein (Cas_Cas02710). Members of this family are found, exclusively in the vicinity of CRISPR repeats and other CRISPR-associated (cas) genes, in Methanothermobacter thermautotrophicus (Methanobacterium thermoformicicum), Thermus thermophilus (Deinococcus-Thermus), Chloroflexus aurantiacus (Chloroflexi), and Thermomicrobium roseum (Thermomicrobia).	0.00159673
NC_017278.1|WP_155983240.1|265468_265717_+|CRISPR-associated-endonuclease-Cas2	gnl|CDD|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	5.38647e-24
NC_017278.1|WP_014514661.1|273177_275055_-|DUF262-domain-containing-protein	gnl|CDD|377008	pfam03235, DUF262, Protein of unknown function DUF262.	5.10536e-28
NC_017278.1|WP_014514485.1|271714_272806_+|IS4-family-transposase	gnl|CDD|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	2.41744e-09
NC_017278.1|WP_014514647.1|252907_254017_-|CRISPR-associated-protein-Cmr3	gnl|CDD|187879	cd09748, Cmr3_III-B, CRISPR/Cas system-associated RAMP superfamily protein Cmr3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; This protein is a subunit of Cmr complex.	5.15356e-86
NC_017278.1|WP_014514643.1|249427_250450_-|type-III-B-CRISPR-module-RAMP-protein-Cmr6	gnl|CDD|213662	TIGR01898, repair_system, CRISPR type III-B/RAMP module RAMP protein Cmr6. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This family, represented by TM1791 of Thermotoga maritima, is designated Cmr6 [sic], for CRISPR/Cas Ramp Module protein 6. This family is both closely related to and frequently encoded next to the TM1792 family of Cas proteins described by TIGR01867. The two proteins are fused in an example from Methanopyrus kandleri.	1.31077e-49
NC_017278.1|WP_155983239.1|261919_263791_+|hypothetical-protein	gnl|CDD|378190	pfam09484, Cas_TM1802, CRISPR-associated protein TM1802 (cas_TM1802). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This minor cas protein is found in at least five prokaryotic genomes: Methanosarcina mazei, Sulfurihydrogenibium azorense, Thermotoga maritima, Carboxydothermus hydrogenoformans, and Dictyoglomus thermophilum, the first of which is archaeal while the rest are bacterial.	3.44437e-48
NC_017278.1|WP_014514638.1|244772_246092_+|cobyrinate-a,c-diamide-synthase	gnl|CDD|234896	PRK01077, PRK01077, cobyrinate a,c-diamide synthase.	0
NC_017278.1|WP_014514646.1|251660_252911_-|type-III-B-CRISPR-module-RAMP-protein-Cmr1	gnl|CDD|224286	COG1367, COG1367, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	3.67153e-30
NC_017278.1|WP_014514656.1|263780_264740_+|type-I-B-CRISPR-associated-protein-Cas7/Csh2	gnl|CDD|187821	cd09690, Cas7_I-B, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Csh2 family.	6.90831e-60
NC_017278.1|WP_014514648.1|254006_255779_-|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	gnl|CDD|274208	TIGR02577, thermophile-specific_DNA_repair_system, CRISPR-associated protein Cas10/Cmr2, subtype III-B. This model represent a Crm2 family of the CRISPR-associated RAMP module, a set of six genes recurring found together in prokaryotic genomes. This gene cluster is found only in species with CRISPR repeats, usually near the repeats themselves. Because most of the six (but not this family) contain RAMP domains, and because its appearance in a genome appears to depend on other CRISPR-associated Cas genes, the set is designated the CRISPR RAMP module. This protein, typified by TM1794 from Thermotoga maritima, is designated Crm2, for CRISPR RAMP Module protein 2.	4.04499e-100
NC_017278.1|WP_014514645.1|250800_251664_-|type-III-B-CRISPR-module-RAMP-protein-Cmr4	gnl|CDD|274210	TIGR02580, putative_CRISPR-associated_protein, CRISPR type III-B/RAMP module RAMP protein Cmr4. This model represents a CRISPR-associated protein from the family that includes TM1792 of Thermotoga maritima. This family is part of the broad RAMP superfamily (pfam03787) collection of CRISPR-associated proteins. It is the fourth of a recurring set of six proteins, four of are in the RAMP superfamily, that we designate the CRISPR RAMP module.	3.42616e-98
NC_017278.1|WP_014514654.1|261200_261923_+|CRISPR-associated-endoribonuclease-Cas6	gnl|CDD|187783	cd09652, Cas6-I-III, CRISPR/Cas system-associated RAMP superfamily protein Cas6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas6 is an endoribonuclease that generates crRNAs, predicted subunit of Cascade complex; RAMP superfamily protein; Possesses double RRM/ferredoxin fold.	7.33055e-24
NC_017278.1|WP_014514653.1|258920_261158_-|CRISPR-associated-endonuclease-Cas3''	gnl|CDD|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	3.55156e-45
NC_017278.1|WP_014514494.1|270255_271476_+|IS256-family-transposase	gnl|CDD|307151	pfam00872, Transposase_mut, Transposase, Mutator family.	3.90236e-89
NC_017278.1|WP_081477220.1|264757_265453_+|CRISPR-associated-protein-Cas5	gnl|CDD|187823	cd09692, Cas5_I-B, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex.	6.84885e-13
NC_017278.1|WP_014514650.1|257447_258431_-|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl|CDD|187853	cd09722, Cas1_I-B, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	4.95502e-156
NC_017278.1|WP_014514644.1|250452_250797_-|type-III-B-CRISPR-module-associated-protein-Cmr5	gnl|CDD|378242	pfam09701, Cas_Cmr5, CRISPR-associated protein (Cas_Cmr5). CRISPR is a term for Clustered, Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family, represented by TM1791.1 of Thermotoga maritima, is found in both archaeal and bacterial species.	6.20177e-28

Protein sequences

>NC_017278.1|WP_014514649.1|255827_256067_-|hypothetical-protein
MAFLRVLEDPVLKAKQVKGLQDLVGVLQSRNQPLLIHGLLVPTEKQVEQVQQLGRELLKALQEEGAPSLELEVLPLERL
>NC_017278.1|WP_014514648.1|254006_255779_-|type-III-B-CRISPR-associated-protein-Cas10/Cmr2
MESLLAISLGPVQDFIATARRTRDLYAGSRLLSEAAGKAAEVLAERLGPERLIFPAPKTKEELAKLGQAGIPNVLLARVSEGLDPGALAEVALGAAREYLREKAKELFTREGRRAYVSLEAALDQVGDLLEGYYAHLPLQGDYPQARERVMALLGARKNTRDFRPVSWGSPAYKSSLDGARESVLLLPESRAEALRVRLRLGLREGEYLSGPDLLKRWWEAEGGFVSTIHMAALPFWEGVRKAGKEGLFRKGLEDLAQLAGEEAKGNTRHPALRDTPFWEWDVRLLYESRLEEFPALGEDPRRLEEARGRLRRLLGELGLGSPGSYYALLHADGDRMGEAIDRQKTPEAHRELSRALALDFAAQVRELVQGRGGGLVYSGGDDVLALLPLHRALETAWALARRFQEVMARFGGGEGKPSLSVGLAVVHHLEPLQDALELARKAERLAKEGPEGTPEDEKRNALGVAYSPRSGSELLVRGRWDETPRLTQRLLRYADLLRAGEVPSRAAHELRELLAWRKGLSEEALVAEALRILGRKAMEKKYRQELSDWIQNARDVERLAQELILARPLAEALDQAGIPVESREVWDAH
>NC_017278.1|WP_014514647.1|252907_254017_-|CRISPR-associated-protein-Cmr3
MLIEPRDPLIVRDGRPFTNSPGARAHSLAFPLPQTLAGAYRARRGMEEGLSFPQDADRVREWGLKGPLLAEEAETGWRLLAPRPLDALKLGERVYALRPLEVPEGAGTNLPQGLFPVGLPKTGLKGKPSPLPAFWYWEDWQRWLLEEAPEGFQPKGHGGPTIEVRTHVSLRPEAGTAREGALFQTSGLEFAYRRGEGDGRPHRLALALWPEDGVEVEGIHPLGGERRLAYWRRGGPPLPPMPSGLLEALWEHRAARIVLLTPAFFRKGYLPEKDAFLGAQVVGAAVGRPVVVSGWDLKKGRPKPTRRAVPPGSVYFVRLPGEWSREEVRAFAEKVWLQNLSEEETDRKDGFGLAALGVWSGKPWRWEEV
>NC_017278.1|WP_014514646.1|251660_252911_-|type-III-B-CRISPR-module-RAMP-protein-Cmr1
MRKFQEAFGPRKREAGGSLVRRDGVRILTWERSYLLLTPLFGGGVEPKRADPVSVVRATEVRGQLRFWWRAVRGWQAEGDLGRLWRLEASLFGHAGEGGASPLAVELEVVEEGKEEAAFQDLPGKNFPRGRSDIAHPYLAFPLQRTRQDPVNHPVRVGVRFRLRLACPERIEGLDPKEELEAALWAWETFGGIGGRTRRGFGALALEGSSPPTEEGIRAQLRRYSRERGWPPGVPHLTPKSLVRVMGLSWREVAEAYRAFRQRRAKDDPRNPGRSRWPEPDQVRRLTGRNHPRHPPRHPVGKFPRARFGLPIIFHFKDEGDPPDTTLKPPLEGTDRLASPLILRPLGKGITLVAILEGSGVPGDRAVLETHDKKRSWEVQVGLTPEEAQRIEPLGGEVDPLRAFLRYLENRAGGGR
>NC_017278.1|WP_014514645.1|250800_251664_-|type-III-B-CRISPR-module-RAMP-protein-Cmr4
MKGHATALLFLHALSPLHPGTGQGLGAIDLPIAREKATGIPYLPGSSLKGVLRDRARGEGWDEDTLEAVFGPETERASEHAGALQVGDARLLLLPVRSLYGVFAHVTSPYLLERFLREARMVGLNPPEGPAAPPQEGVAVAPGSHLAAEGRVFLEDLDLRAQAGEAVGAWEAWLSQQTQAPVGGRMAVVHDDLMGFLLETATEVVARIRLEDTTKTVARGALWYEESLPAESVLYSLVRTEASHRKTKPLGAASVLELFQGLVDGQALQLGGKATVGRGLCRVRVGR
>NC_017278.1|WP_014514644.1|250452_250797_-|type-III-B-CRISPR-module-associated-protein-Cmr5
MRTRSQNWAQAAYERVRARKDWEKREEYQDMALKLPVLVRQAGLSQALAFVHSRGKEGHRAVGDDLAAVLGHGNLEALAEAARRAELLQYLRLTREVLQVAEWFKRFAQALLED
>NC_017278.1|WP_014514643.1|249427_250450_-|type-III-B-CRISPR-module-RAMP-protein-Cmr6
MGRREALQGVRLDPQGTHRGLWLDKYLAEAEREDTEAKGRLVKEVAGIAEPQGYGAFFARYLEALEAMGAETRRATTRSRLVVGLGGEGVLETSLTLHRTYSVPYIPGSALKGLASRYAHLYLEGEAWRRDPRGEAQAGLFGTTEEQGAVVFFDALPYPKTWRIHPDLMNPHHADYYGGGGAPPADWDSPVPVPFLSVKGTFLLALAPAPGVPREEARPWLQAAWRILAWALREEGVGAKTASGYGRMDLEGESAPSPPQAASSPAYEALRTQLRSTKYRDLPAFLEREAQAILGLSPQELRGLKEAMEERKFLQNAADLKAWAKRSETLRQVLQKLGVL
>NC_017278.1|WP_155983238.1|247484_249431_+|hypothetical-protein
MHWALVSLVGNDPAPGAMGARVFLRRFAASTPAPRVFLVRDHSPEEPLRRPRLEALQGWLHGLGFRVEWVDLGFVEGHQEPLVLNLTGGDKATFFRLYRLASARGWPGFLIEAHGAQPVLVELSGWVGPLPKEEGLSLEDYLALYARPAGAKPRGEPGRVPPALAGVSWTLLDLEGEEVLYGVEAGRPLVFLPRPHPAFKDQVNRLREKAKRLGGQQALGVALLPMDKVLGQHENNREWVLAHYQTYAREAGVLALDPREEGALGRALSLPSPNPGAKDLPFRPPEAGPVLLGLLSEQPIPLLASFLVHRPKEVLLVSTQDLERRLGRLASAQAAFSRLGARVQVRQVSGPWALDEVEALFAPVLGAIQARGLSGVANLAGGTKAMALGLLRVLPPGFRVEYLRGSTLEGLPEGDPLPVPWAEVGPEAVLHLYGYQLERDPKLGQIQPHQEVLARAEEFLRHVEDPQRARAFLEAWEKSFAAEAEGFRLRWRDLRPSAGLALEYLAFFHLHRLLTPRGARVEPGAHLRPLWAHPGLNPREVDGLVWHRGSLAFVECKPDLRSALSKHQEDAALFVLQENFGGVFGRGLLLVQRGRWKPHEKPPAELPWVLRNPRLRLLSLEGGTPYPGGRVYAFPEELEEALRDWGWP
>NC_017278.1|WP_155983237.1|246083_246497_-|hypothetical-protein
MGEALEAVLLRLPEGVGPLPLPTGVADPLLVAVEACAQDLLEVHPRQKPGRVIPTRGRLHLPLLKIVLYQSQARGYHKSIKKKDKNPLRSTPSHKSDSHGGRLIQLPHLFGQLGQGEVKEASPRENRGQRTLPKPLP
>NC_017278.1|WP_014514638.1|244772_246092_+|cobyrinate-a,c-diamide-synthase
MQLPRLLLAAPHSGAGKTTLALALLQALRERGLAVQPFKVGPDYIDPTHLELASGRRPYNLDGFFLDGEGLLSLFRHGARGADLALIEGVMGLFDGKDPQGRVGSTAQVARLLQAPVVLVVDAGGMAGSIAPLVQGFARFDPGVRVVGVLANRVGSARHAEILREALAPLGLPLLGWLPLDPGLELPERHLGLVLAGEVRPPLEALRKALRLDLEGLLRLAGEAPPLPEAPPFLPERHPPRARVAYAWDRAFRFYYPEALELLEALGAELIPFSPLADGALPQAEALLLGGGYPELFARELSENTPMREAIRRFRGPVVAECGGYMYLSRGLWVGEAFFPMVGLVPGEARMGERPVLGYREVEALRDSPLAQRGEAFKGHEFHYAHLPPSPSPAWRRVGGEEVEGYTDGRVLASFVHLYLPARPQGALRLLLSAQNPLG
>NC_017278.1|WP_014514650.1|257447_258431_-|type-I-B-CRISPR-associated-endonuclease-Cas1
MPKPVYIFSSGRLSRLANTLVLETEDRKRHLPVEQVSELYLFGEVDLNKRFLEFAAQKGILLHFFNRFGYYVGSFYPREHLLSGYLTLRQAQHYLDANRRLNLARRFVEGGLENIRRLLRKEEAKGKRVSDALDTIGEILSQVKGAQHVGELMALEGRARESYYAVWDELLGEEWSLERNRRPPKDPVNALVSFGNTLLYTAILAQIYQTHLDPRIGFLHEANYRRHSLNLDVAEVFKPVLVDRMIFRLIRRGQIKTGHFLREGQGVFLSEAGKRLVVEEWENSLQATYRHLSLKRSVSYRTTLRLELYKLEKHLIEENPYIPYRFR
>NC_017278.1|WP_014514653.1|258920_261158_-|CRISPR-associated-endonuclease-Cas3''
MLLARTSPDEPLLEHLLGVGALAEGYLAPLGLGEEGRLAGLCHDLGKATPYFQEMLAGQRAKGDPLTWHALLGALYAAWTARQRGMGEKSLLLFLAVLEHHGSLKTPWERIPLGPRQASEKAWKILPKQIRALQESPLFPALVADLGLPPPEAFLGEGAWEEAERLAREADALLDREGRDLGLHYRLALLYSALLDADRRLAGQAPPKGEGIPIPPEAAEAHLARKSRPTPLSPQREALFRGVGEVLEGPLERVFPARLTLTAPTGAGKTLAALRFALALRERVHRERGFRPKVVYALPYIAIADQVEEEARGVLQAAGLKPEEHLLVHHHLALAREEEGSVEEALLLQETWDAEVVVTTFHQLFPTLVGPGSALRPLHALAKGAILILDEVQTLPAELWPFLGELLRQLPGQMTVISMTATQPGLVKGQEVAPHLPSYPRRVRLAWHGARTLEELGQALLQEGPKSRLVVVNTVREAISLYRFLREEGLPHLYLLTSHIIPKHRKARLGEIRAKLQEGQPLTLVATQVVEAGVDLDFQEGYRAFAPMESILQVAGRVNRSALGEGRLWVLDLEGDGGRRVYGTILLDRSRRVLGPRLAEGLWDLEAYALLPQYYRLVEEGISQAKGQDLLAKLARLDYSQLRFTLIEEAPSIPIFIEWDQEATRLLGELEGALTLKDPGERRKRLRPLLARIQGYTVSPLLQRALKNLPPPLLGREEWRHVPREAVADFYDEEMGFLWEMEQFL
>NC_017278.1|WP_014514654.1|261200_261923_+|CRISPR-associated-endoribonuclease-Cas6
MPSEGGRLSLRFFAEGRLPVTYREGLQAALYQALPLPLGQRLHDGGLLEGHRPLKLFVFSRLQGLLYLREEKAFLAQGELVLHFASALPEVVEGLAKGVWERGGLEVHGLFLRLLGMDLDPLPEGGDLVVEALSPITAYRTEGGRTLYFNPLNREFALLLEANLVRKAQLLGLEAGSLALKPVGFRPQHKRVERYKDTWIEGWMGRYRLEGSPHLIRLALLTGLGAKNSQGFGFVREVKG
>NC_017278.1|WP_155983239.1|261919_263791_+|hypothetical-protein
MIRQLLRLGQSGGEGFRLEDYVQRASGRLYLLDLDPQNRVAGFTPYELDEEKCARFLWVGDPPASNAPRDRATTKDLRYLLGQVPTRMAEHSGLKSLLQGFLWDPGKPGGKARYLLDLRGWRLQGAKDAEAPPFRIQGGRLEMDGTAEGKTAGELAEALAQVLRAAYDIRSPEKGGVLLFSLALSGKPLAEYPEYGDYLRQRLLQEPFAEAQMGICHGCGRKDRVTGNFSAFRLKFYITDKKSFAPGVDEGAFPRAYALCQTCFAALGVGERLAWERLRQRFLERDVLVLPEADFPQESLERLLERLVGQVQGLERLERWKDFLERAAHRQEEVRYLGFSLLFFQRAQAATKAEELVLEVPPSRVEAILKTLQEARERGFPVEGLRDWLFLMPLSRGRKGEMGQMGLALQAVSRIFLQLPLFPKDLLPLWLKTAERVYREDGTLYALTRYRAGQGVIDLVNLGAGWMWVLQRLEVWGGNMEGEVKGALPLTEEEKPLFEAYGFGALRAGLYLLGQAMEAVGQAQARLSEYRKEPLLDSIGWQGMSLVRVRHLVPEVMAKATYYLEGDDRTRVLDLLGRATDLLERSRESLSEREVPYYILMGYAQARSKRLRSGRREEVTHGG
>NC_017278.1|WP_014514656.1|263780_264740_+|type-I-B-CRISPR-associated-protein-Cas7/Csh2
MVANAEILYLYEAKDTNPNGDPDAENRPRMDYVGQRLLVSDVRLKRYVRDYLLARGEDVWVRSREDGSRTDADGRLEDLKGLYKEETGRDAGAKKKDLDPEFLAWYLRRLRDVRLFGAVLPIKAEGESKGGTGQFVGAVQFDWGYSLHPVEVYTATISSVFAGRTEGGKGEHGTFGKDHRVHYALIAFWGRVSKRRGEAVGLTSEDLEVLEKGLLEGLLEGATTRSKVGQTPRLYLRVDWKEGFRPMGDPRDGLSIRPVEGKAPEGIRSVRDYVLQAHALSESLNSLRESIARVRLWQHPDLQLEGLNLSGLSLEEVNL
>NC_017278.1|WP_081477220.1|264757_265453_+|CRISPR-associated-protein-Cas5
MKGKRAHFRRFYTNSSSLTYPVPPPTTVQGLLAAALGLGEEYLGELRGLWVSARPTAPLRHAFQTVNYLFLKEGKLEELRGLYREGRTQIPVQYLLGEEGRPVAFEVYVASERKGIVEGLGEALANPAYPLALGPAYALAWAEGISILEADLRSHWTGIGLGWWEAGKLRLQGTPLGARLYRDRFPLSLGPGRQPMRIGELALEVRGEPLPVQYEGEVLMLGEVAVGVVQV
>NC_017278.1|WP_155983240.1|265468_265717_+|CRISPR-associated-endonuclease-Cas2
MVYDVAVERVVKVLKVGRRYLTWVQNSVLEGELSPAQYARLKAEVRKIIEPSDAVRFYLFPNRDSLRIETIGSTKNEPDQFI
>NC_017278.1|WP_014514494.1|270255_271476_+|IS256-family-transposase
MFNRGAHLSTRRCPVDQDTLRILLREAVRETVAEVLQTVLELDRTAFLQVHGGRRNGYYPRKLETTFGQVDLKVPRDRESRYYPAFLKPYVRRLVDVGEVAVALYAAGVSQRKAAEILSLLLGHRYSHETLSALTDEVLEAAGAFRTRPLPEEMAFVYLDGLSLKVFREGEGIVRESVYVALGIAPNGERRVLGFWLLPTESALGWEGVLGELWQRGLRRVLLFITDGLPGLPEAIRRVYPQAEWQRCVVHGVRWSLSQVRARDRGLLAEDLRRVYGAESREEALGALEEVKAAWGSRYPGVVGLWVQDSGAFLRFYGYPKVLWPYLRSTNLMERFIREVRRGTKVRDHKFPKEEAVYKLLYLESERQEGRWAERKLKGFSEVKEVLEKMLQERYAPRTQTLTHNS
>NC_017278.1|WP_014514485.1|271714_272806_+|IS4-family-transposase
MEQLTPLINALKRYWKADLRRLTFLAALVMALVTARTTSGPRLALSLGSIASPDPRSAYRRFQRFLAWPGLDGEGYARFIFALLRPQGLLLVMDRTEWELGKSKVNLLMLAFLYQGLAVPLFWSFLPHDGNSSTPERIALMERALAFLRAHFPHLRVEGFLADREFIGEAWFRYLEEKGIPRCIRIKANTRMWRLGSGPRAWELFASLKVGESRVPRRRYWVYGRRMWVVGLRLGVREWLIVATDLDPHRVLEVYGLRWGIERLFGALKGRGFDLEATHVTRGERLSRLLVPLSLAFVWAFRTGLVLHRVRPVRPKKHGRLGQSLFRAGLDLLTLWALALWGAGGGRRGSPLGLCPMEVLTCT
>NC_017278.1|WP_014514661.1|273177_275055_-|DUF262-domain-containing-protein
MPPVHRLLHITLDTTIDMNGADILLKGLNLKTQKKGGRRQMDNERIQTKVFRIRQLLESSVVYQVPRFQRPYSWSRVHWKTFLEDIENTCHLSKDGMPYLHFLGAIITMARPSGVEVVAPYILVDGQQRLITIALLLAAIRNRAAEAGLSSLSHELDKLLRNADEELELKVQPTEFDEAALRGIIRGTPLEELHSPIGNAYSFFTDKLKGRAPEELEVLAKALLDQTEVVRIHLSQGENAYRIFESLNYKGSPLTPADLVRNYLFMRLAAEGKEKEKETYEKVWAPVEEAYKKVFPPSPANSIPHLERMSLGIWHYVRTNGEEIPWDATYPALIDRLNATLKEGKATESFALELKESLADYLFFERPHLETNPKLQRRLEAFRILGFGVAAPLVMALKQRIRKGVLDIEDADQVLAVMEAYYLHRILASVPTNTVGRTVLSVLKNGLLDEPNPAEKVRRFLKGLSGNRRWPDREELEKRNAERSIYVWDGGGRDPRTSHAYYILKRIEQYLWKKLKRKELPNLENLTLEHIMPRTLSEAWKAEIGIDWERTHKSHLNALGNLTLTGYNQEMGNKPFSEKLKVLRESTLSINQEYFRSVSLERWDEQAIRERTKWLLDLVYEIWPA

Crispr_ID: NC_017278_3

• CRISPR_ID: NC_017278_3
• CRISPR_location: 265902-266882
• CRISPR_type: TypeIII
• Repeat_type: NA
• Spacer_info: 14 spacers
• Cas_protein_info: cas2,cas5,cas7,cas8b1,cas6,cas3,cas1,cas10,cmr3gr5

Consensus repeat of NC_017278_3

Consensus_repeat	Method
TTTCAAACCCTTATAGGTACGGTTCAAAG	PILER-CR
CTTTGAACCGTACCTATAAGGGTTTGAAAC	CRISPRCasFinder
CTTTGAACCGTACCTATAAGGGTTTGAAAC	CRT

spacers of NC_017278_3

>3.1|265931|39|NC_017278|PILER-CR
CAGGGTGCGGACCACCAAAGCGCCCCCCGCGTACTCAAC
>3.2|265999|38|NC_017278|PILER-CR
CAGGGCAACCTGTGCGCCCCAGGGCACACCACTAACTC
>3.3|266066|42|NC_017278|PILER-CR
CGGGTTGACCTCGGCCTTGGGGACCCCCTTATCGGCCTTGGG
>3.4|266137|38|NC_017278|PILER-CR
CGGCCGTGCACGGGTAGGGGGGTGGACCGGGACAGCCC
>3.5|266204|39|NC_017278|PILER-CR
CTGAGGCCCTCCATAGGGCTTGGCGTAGGGGGTGGGAAG
>3.6|266272|40|NC_017278|PILER-CR
CTCGCTGTTCTCCATCTTTTTCCTGCGTGGGCTCCCAATG
>3.7|266341|41|NC_017278|PILER-CR
CAGGGTATGGACCCGGGGGCGGTTGTAGCCGCCCTTAAACG
>3.8|266411|39|NC_017278|PILER-CR
CGCACCCACTTGGTGAACAAAGTTTTTGCCACACGCCTT
>3.9|266479|36|NC_017278|PILER-CR
CGACGGCCTGGACCCCCAGGCCGTTGCCGCCCACTT
>3.10|266544|38|NC_017278|PILER-CR
CCCTTCCACAGCAACTTTTACTTTGACCATAACTCCTC
>3.11|266611|38|NC_017278|PILER-CR
CGGCTTCGCCTTCGCGGCACCATCCTCTTCATCCCCTG
>3.12|266678|38|NC_017278|PILER-CR
CTATTCTGGGGGCGGGACCGCGTGTCCTGCCCCACACC
>3.13|266745|39|NC_017278|PILER-CR
CCCATGCGCCGCGCCATGAAGACGGGAAGCCAGCCCCCT
>3.14|266813|39|NC_017278|PILER-CR
CGTTCCTCAATAGGCCACTACGGGGTCAACCCCGAGGGC
>3.15|265932|38|NC_017278|CRISPRCasFinder,CRT
AGGGTGCGGACCACCAAAGCGCCCCCCGCGTACTCAAC
>3.16|266000|37|NC_017278|CRISPRCasFinder,CRT
AGGGCAACCTGTGCGCCCCAGGGCACACCACTAACTC
>3.17|266067|41|NC_017278|CRISPRCasFinder,CRT
GGGTTGACCTCGGCCTTGGGGACCCCCTTATCGGCCTTGGG
>3.18|266138|37|NC_017278|CRISPRCasFinder,CRT
GGCCGTGCACGGGTAGGGGGGTGGACCGGGACAGCCC
>3.19|266205|38|NC_017278|CRISPRCasFinder,CRT
TGAGGCCCTCCATAGGGCTTGGCGTAGGGGGTGGGAAG
>3.20|266273|39|NC_017278|CRISPRCasFinder,CRT
TCGCTGTTCTCCATCTTTTTCCTGCGTGGGCTCCCAATG
>3.21|266342|40|NC_017278|CRISPRCasFinder,CRT
AGGGTATGGACCCGGGGGCGGTTGTAGCCGCCCTTAAACG
>3.22|266412|38|NC_017278|CRISPRCasFinder,CRT
GCACCCACTTGGTGAACAAAGTTTTTGCCACACGCCTT
>3.23|266480|35|NC_017278|CRISPRCasFinder,CRT
GACGGCCTGGACCCCCAGGCCGTTGCCGCCCACTT
>3.24|266545|37|NC_017278|CRISPRCasFinder,CRT
CCTTCCACAGCAACTTTTACTTTGACCATAACTCCTC
>3.25|266612|37|NC_017278|CRISPRCasFinder,CRT
GGCTTCGCCTTCGCGGCACCATCCTCTTCATCCCCTG
>3.26|266679|37|NC_017278|CRISPRCasFinder,CRT
TATTCTGGGGGCGGGACCGCGTGTCCTGCCCCACACC
>3.27|266746|38|NC_017278|CRISPRCasFinder,CRT
CCATGCGCCGCGCCATGAAGACGGGAAGCCAGCCCCCT
>3.28|266814|38|NC_017278|CRISPRCasFinder,CRT
GTTCCTCAATAGGCCACTACGGGGTCAACCCCGAGGGC

CRISPR arrays and Neighbor proteins around NC_017278_3

CRISPR arrays

The CRISPR arrays of NC_017278_3

>merge|NC_017278|3|265902-266882|PILER-CR,CRISPRCasFinder,CRT
CTTTGAACCGTACCTATAAGGGTTTGAAACAGGGTGCGGACCACCAAAGCGCCCCCCGCGTACTCAACCTTTGAACCGTACCTATAAGGGTTTGAAACAGGGCAACCTGTGCGCCCCAGGGCACACCACTAACTCCTTTGAACCGTACCTATAAGGGTTTGAAACGGGTTGACCTCGGCCTTGGGGACCCCCTTATCGGCCTTGGGCTTTGAACCGTACCTATAAGGGTTTGAAACGGCCGTGCACGGGTAGGGGGGTGGACCGGGACAGCCCCTTTGAACCGTACCTATAAGGGTTTGAAACTGAGGCCCTCCATAGGGCTTGGCGTAGGGGGTGGGAAGCTTTGAACCGTACCTATAAGGGTTTGAAACTCGCTGTTCTCCATCTTTTTCCTGCGTGGGCTCCCAATGCTTTGAACCGTACCTATAAGGGTTTGAAACAGGGTATGGACCCGGGGGCGGTTGTAGCCGCCCTTAAACGCTTTGAACCGTACCTATAAGGGTTTGAAACGCACCCACTTGGTGAACAAAGTTTTTGCCACACGCCTTCTTTGAACCGTACCTATAAGGGTTTGAAACGACGGCCTGGACCCCCAGGCCGTTGCCGCCCACTTCTTTGAACCGTACCTATAAGGGTTTGAAACCCTTCCACAGCAACTTTTACTTTGACCATAACTCCTCCTTTGAACCGTACCTATAAGGGTTTGAAACGGCTTCGCCTTCGCGGCACCATCCTCTTCATCCCCTGCTTTGAACCGTACCTATAAGGGTTTGAAACTATTCTGGGGGCGGGACCGCGTGTCCTGCCCCACACCCTTTGAACCGTACCTATAAGGGTTTGAAACCCATGCGCCGCGCCATGAAGACGGGAAGCCAGCCCCCTCTTTGAACCGTACCTATAAGGGTTTGAAACGTTCCTCAATAGGCCACTACGGGGTCAACCCCGAGGGCCTTTGAACCGTACCTATAAGGGTTTGAACTA

>NC_017278|3|3|265902-266880|PILER-CR
CTTTGAACCGTACCTATAAGGGTTTGAAA	CAGGGTGCGGACCACCAAAGCGCCCCCCGCGTACTCAAC
CTTTGAACCGTACCTATAAGGGTTTGAAA	CAGGGCAACCTGTGCGCCCCAGGGCACACCACTAACTC
CTTTGAACCGTACCTATAAGGGTTTGAAA	CGGGTTGACCTCGGCCTTGGGGACCCCCTTATCGGCCTTGGG
CTTTGAACCGTACCTATAAGGGTTTGAAA	CGGCCGTGCACGGGTAGGGGGGTGGACCGGGACAGCCC
CTTTGAACCGTACCTATAAGGGTTTGAAA	CTGAGGCCCTCCATAGGGCTTGGCGTAGGGGGTGGGAAG
CTTTGAACCGTACCTATAAGGGTTTGAAA	CTCGCTGTTCTCCATCTTTTTCCTGCGTGGGCTCCCAATG
CTTTGAACCGTACCTATAAGGGTTTGAAA	CAGGGTATGGACCCGGGGGCGGTTGTAGCCGCCCTTAAACG
CTTTGAACCGTACCTATAAGGGTTTGAAA	CGCACCCACTTGGTGAACAAAGTTTTTGCCACACGCCTT
CTTTGAACCGTACCTATAAGGGTTTGAAA	CGACGGCCTGGACCCCCAGGCCGTTGCCGCCCACTT
CTTTGAACCGTACCTATAAGGGTTTGAAA	CCCTTCCACAGCAACTTTTACTTTGACCATAACTCCTC
CTTTGAACCGTACCTATAAGGGTTTGAAA	CGGCTTCGCCTTCGCGGCACCATCCTCTTCATCCCCTG
CTTTGAACCGTACCTATAAGGGTTTGAAA	CTATTCTGGGGGCGGGACCGCGTGTCCTGCCCCACACC
CTTTGAACCGTACCTATAAGGGTTTGAAA	CCCATGCGCCGCGCCATGAAGACGGGAAGCCAGCCCCCT
CTTTGAACCGTACCTATAAGGGTTTGAAA	CGTTCCTCAATAGGCCACTACGGGGTCAACCCCGAGGGC
CTTTGAACCGTACCTATAAGGGTTTGAAC

>NC_017278|3|3|265902-266882|CRISPRCasFinder
CTTTGAACCGTACCTATAAGGGTTTGAAAC	AGGGTGCGGACCACCAAAGCGCCCCCCGCGTACTCAAC
CTTTGAACCGTACCTATAAGGGTTTGAAAC	AGGGCAACCTGTGCGCCCCAGGGCACACCACTAACTC
CTTTGAACCGTACCTATAAGGGTTTGAAAC	GGGTTGACCTCGGCCTTGGGGACCCCCTTATCGGCCTTGGG
CTTTGAACCGTACCTATAAGGGTTTGAAAC	GGCCGTGCACGGGTAGGGGGGTGGACCGGGACAGCCC
CTTTGAACCGTACCTATAAGGGTTTGAAAC	TGAGGCCCTCCATAGGGCTTGGCGTAGGGGGTGGGAAG
CTTTGAACCGTACCTATAAGGGTTTGAAAC	TCGCTGTTCTCCATCTTTTTCCTGCGTGGGCTCCCAATG
CTTTGAACCGTACCTATAAGGGTTTGAAAC	AGGGTATGGACCCGGGGGCGGTTGTAGCCGCCCTTAAACG
CTTTGAACCGTACCTATAAGGGTTTGAAAC	GCACCCACTTGGTGAACAAAGTTTTTGCCACACGCCTT
CTTTGAACCGTACCTATAAGGGTTTGAAAC	GACGGCCTGGACCCCCAGGCCGTTGCCGCCCACTT
CTTTGAACCGTACCTATAAGGGTTTGAAAC	CCTTCCACAGCAACTTTTACTTTGACCATAACTCCTC
CTTTGAACCGTACCTATAAGGGTTTGAAAC	GGCTTCGCCTTCGCGGCACCATCCTCTTCATCCCCTG
CTTTGAACCGTACCTATAAGGGTTTGAAAC	TATTCTGGGGGCGGGACCGCGTGTCCTGCCCCACACC
CTTTGAACCGTACCTATAAGGGTTTGAAAC	CCATGCGCCGCGCCATGAAGACGGGAAGCCAGCCCCCT
CTTTGAACCGTACCTATAAGGGTTTGAAAC	GTTCCTCAATAGGCCACTACGGGGTCAACCCCGAGGGC
CTTTGAACCGTACCTATAAGGGTTTGAACTA

>NC_017278|3|3|265902-266881|CRT
CTTTGAACCGTACCTATAAGGGTTTGAAAC	AGGGTGCGGACCACCAAAGCGCCCCCCGCGTACTCAAC
CTTTGAACCGTACCTATAAGGGTTTGAAAC	AGGGCAACCTGTGCGCCCCAGGGCACACCACTAACTC
CTTTGAACCGTACCTATAAGGGTTTGAAAC	GGGTTGACCTCGGCCTTGGGGACCCCCTTATCGGCCTTGGG
CTTTGAACCGTACCTATAAGGGTTTGAAAC	GGCCGTGCACGGGTAGGGGGGTGGACCGGGACAGCCC
CTTTGAACCGTACCTATAAGGGTTTGAAAC	TGAGGCCCTCCATAGGGCTTGGCGTAGGGGGTGGGAAG
CTTTGAACCGTACCTATAAGGGTTTGAAAC	TCGCTGTTCTCCATCTTTTTCCTGCGTGGGCTCCCAATG
CTTTGAACCGTACCTATAAGGGTTTGAAAC	AGGGTATGGACCCGGGGGCGGTTGTAGCCGCCCTTAAACG
CTTTGAACCGTACCTATAAGGGTTTGAAAC	GCACCCACTTGGTGAACAAAGTTTTTGCCACACGCCTT
CTTTGAACCGTACCTATAAGGGTTTGAAAC	GACGGCCTGGACCCCCAGGCCGTTGCCGCCCACTT
CTTTGAACCGTACCTATAAGGGTTTGAAAC	CCTTCCACAGCAACTTTTACTTTGACCATAACTCCTC
CTTTGAACCGTACCTATAAGGGTTTGAAAC	GGCTTCGCCTTCGCGGCACCATCCTCTTCATCCCCTG
CTTTGAACCGTACCTATAAGGGTTTGAAAC	TATTCTGGGGGCGGGACCGCGTGTCCTGCCCCACACC
CTTTGAACCGTACCTATAAGGGTTTGAAAC	CCATGCGCCGCGCCATGAAGACGGGAAGCCAGCCCCCT
CTTTGAACCGTACCTATAAGGGTTTGAAAC	GTTCCTCAATAGGCCACTACGGGGTCAACCCCGAGGGC
CTTTGAACCGTACCTATAAGGGTTTGAACT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_017278.1|WP_014514649.1|255827_256067_-|hypothetical-protein	unknown	unknown	gnl|CDD|378236
NC_017278.1|WP_155983240.1|265468_265717_+|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|187856
NC_017278.1|WP_041433934.1|283204_283957_-|DUF721-domain-containing-protein	unknown	unknown	gnl|CDD|377496
NC_017278.1|WP_014514663.1|276723_279642_-|HsdR-family-type-I-site-specific-deoxyribonuclease	unknown	unknown	gnl|CDD|273028
NC_017278.1|WP_014514648.1|254006_255779_-|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	cas10	cls000742_cas10_CAS-III	gnl|CDD|274208
NC_017278.1|WP_014514665.1|280912_282481_-|type-I-restriction-modification-system-subunit-M	unknown	unknown	gnl|CDD|223363
NC_017278.1|WP_155983239.1|261919_263791_+|hypothetical-protein	cas8b1	pfam09484_cas8b1_CAS-I-B	gnl|CDD|378190
NC_017278.1|WP_014514650.1|257447_258431_-|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl|CDD|187853
NC_017278.1|WP_014514485.1|271714_272806_+|IS4-family-transposase	unknown	unknown	gnl|CDD|376573
NC_017278.1|WP_014514656.1|263780_264740_+|type-I-B-CRISPR-associated-protein-Cas7/Csh2	cas7	cd09690_cas7_CAS-I-B	gnl|CDD|187821
NC_017278.1|WP_081477220.1|264757_265453_+|CRISPR-associated-protein-Cas5	cas5	mkCas0191_cas5_CAS-I-B	gnl|CDD|187823
NC_017278.1|WP_081477222.1|279638_280916_-|restriction-endonuclease-subunit-S	unknown	unknown	gnl|CDD|341175
NC_017278.1|WP_014514654.1|261200_261923_+|CRISPR-associated-endoribonuclease-Cas6	cas6	pfam01881_cas6_CAS-I:CAS-III	gnl|CDD|187783
NC_017278.1|WP_014514653.1|258920_261158_-|CRISPR-associated-endonuclease-Cas3''	cas3	COG1203_cas3_CAS-I	gnl|CDD|224124
NC_017278.1|WP_014514494.1|270255_271476_+|IS256-family-transposase	unknown	unknown	gnl|CDD|307151
NC_017278.1|WP_014514647.1|252907_254017_-|CRISPR-associated-protein-Cmr3	cmr3gr5	cd09748_cmr3gr5_CAS-III-B	gnl|CDD|187879
NC_017278.1|WP_081477221.1|276398_276731_-|M48-family-metallopeptidase	unknown	unknown	gnl|CDD|320703
NC_017278.1|WP_014514667.1|283941_284973_-|DNA-replication-and-repair-protein-RecF	unknown	unknown	gnl|CDD|184491
NC_017278.1|WP_014514661.1|273177_275055_-|DUF262-domain-containing-protein	unknown	unknown	gnl|CDD|377008
NC_017278.1|WP_014514662.1|275017_276238_-|IS256-family-transposase	unknown	unknown	gnl|CDD|307151

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_017278.1|WP_014514656.1|263780_264740_+|type-I-B-CRISPR-associated-protein-Cas7/Csh2	cas7	cd09690_cas7_CAS-I-B	2.6e-64	212.0	0.0
NC_017278.1|WP_155983240.1|265468_265717_+|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	5.8e-23	75.7	0.0
NC_017278.1|WP_014514648.1|254006_255779_-|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	cas10	cls000742_cas10_CAS-III	2.5e-105	347.9	0.0
NC_017278.1|WP_014514654.1|261200_261923_+|CRISPR-associated-endoribonuclease-Cas6	cas6	pfam01881_cas6_CAS-I:CAS-III	3e-24	80.9	0.0
NC_017278.1|WP_014514653.1|258920_261158_-|CRISPR-associated-endonuclease-Cas3''	cas3	COG1203_cas3_CAS-I	5.8e-48	158.4	0.0
NC_017278.1|WP_081477220.1|264757_265453_+|CRISPR-associated-protein-Cas5	cas5	mkCas0191_cas5_CAS-I-B	1.3e-105	346.1	3.7
NC_017278.1|WP_014514647.1|252907_254017_-|CRISPR-associated-protein-Cmr3	cmr3gr5	cd09748_cmr3gr5_CAS-III-B	3.1e-92	304.4	5.8
NC_017278.1|WP_155983239.1|261919_263791_+|hypothetical-protein	cas8b1	pfam09484_cas8b1_CAS-I-B	2.9e-49	162.9	0.0
NC_017278.1|WP_014514650.1|257447_258431_-|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	3.8e-127	418.6	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_017278.1|WP_014514649.1|255827_256067_-|hypothetical-protein	gnl|CDD|378236	pfam09670, Cas_Cas02710, CRISPR-associated protein (Cas_Cas02710). Members of this family are found, exclusively in the vicinity of CRISPR repeats and other CRISPR-associated (cas) genes, in Methanothermobacter thermautotrophicus (Methanobacterium thermoformicicum), Thermus thermophilus (Deinococcus-Thermus), Chloroflexus aurantiacus (Chloroflexi), and Thermomicrobium roseum (Thermomicrobia).	0.00159673
NC_017278.1|WP_155983240.1|265468_265717_+|CRISPR-associated-endonuclease-Cas2	gnl|CDD|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	5.38647e-24
NC_017278.1|WP_041433934.1|283204_283957_-|DUF721-domain-containing-protein	gnl|CDD|377496	pfam05258, DUF721, Protein of unknown function (DUF721). This family contains several actinomycete proteins of unknown function.	4.91676e-16
NC_017278.1|WP_014514663.1|276723_279642_-|HsdR-family-type-I-site-specific-deoxyribonuclease	gnl|CDD|273028	TIGR00348, R_protein, type I site-specific deoxyribonuclease, HsdR family. This gene is part of the type I restriction and modification system which is composed of three polypeptides R (restriction endonuclease), M (modification) and S (specificity). This group of enzymes recognize specific short DNA sequences and have an absolute requirement for ATP (or dATP) and S-adenosyl-L-methionine. They also catalyse the reactions of EC 2.1.1.72 and EC 2.1.1.73, with similar site specificity.(J. Mol. Biol. 271 (3), 342-348 (1997)). Members of this family are assumed to differ from each other in DNA site specificity. [DNA metabolism, Restriction/modification].	1.68417e-143
NC_017278.1|WP_014514648.1|254006_255779_-|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	gnl|CDD|274208	TIGR02577, thermophile-specific_DNA_repair_system, CRISPR-associated protein Cas10/Cmr2, subtype III-B. This model represent a Crm2 family of the CRISPR-associated RAMP module, a set of six genes recurring found together in prokaryotic genomes. This gene cluster is found only in species with CRISPR repeats, usually near the repeats themselves. Because most of the six (but not this family) contain RAMP domains, and because its appearance in a genome appears to depend on other CRISPR-associated Cas genes, the set is designated the CRISPR RAMP module. This protein, typified by TM1794 from Thermotoga maritima, is designated Crm2, for CRISPR RAMP Module protein 2.	4.04499e-100
NC_017278.1|WP_014514665.1|280912_282481_-|type-I-restriction-modification-system-subunit-M	gnl|CDD|223363	COG0286, HsdM, Type I restriction-modification system methyltransferase subunit [Defense mechanisms].	1.56208e-108
NC_017278.1|WP_155983239.1|261919_263791_+|hypothetical-protein	gnl|CDD|378190	pfam09484, Cas_TM1802, CRISPR-associated protein TM1802 (cas_TM1802). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This minor cas protein is found in at least five prokaryotic genomes: Methanosarcina mazei, Sulfurihydrogenibium azorense, Thermotoga maritima, Carboxydothermus hydrogenoformans, and Dictyoglomus thermophilum, the first of which is archaeal while the rest are bacterial.	3.44437e-48
NC_017278.1|WP_014514650.1|257447_258431_-|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl|CDD|187853	cd09722, Cas1_I-B, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	4.95502e-156
NC_017278.1|WP_014514485.1|271714_272806_+|IS4-family-transposase	gnl|CDD|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	2.41744e-09
NC_017278.1|WP_014514656.1|263780_264740_+|type-I-B-CRISPR-associated-protein-Cas7/Csh2	gnl|CDD|187821	cd09690, Cas7_I-B, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Csh2 family.	6.90831e-60
NC_017278.1|WP_081477220.1|264757_265453_+|CRISPR-associated-protein-Cas5	gnl|CDD|187823	cd09692, Cas5_I-B, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex.	6.84885e-13
NC_017278.1|WP_081477222.1|279638_280916_-|restriction-endonuclease-subunit-S	gnl|CDD|341175	cd17286, RMtype1_S_Lla161ORF747P_TRD1-CR1_like, Type I restriction-modification system specificity (S) subunit TRD-CR, similar to Lactococcus lactis subsp. lactis Dephy 1 S subunit (S.Lla161ORF747P) TRD1-CR1, and Lactococcus lactis IO-1 S subunit (S2.LlaIO1ORF1141P) TRD2-CR2. The recognition sequences of Lactococcus lactis subsp. lactis Dephy 1 S subunit (S.Lla161ORF747P) and Lactococcus lactis IO-1 S subunit (S2.LlaIO1ORF1141P) are undetermined. The restriction-modification (RM) system S subunit consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one heteromeric enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. It may also include TRD-CR-like sequence-recognition domains of various type II restriction enzymes and methyltransferases and type I DNA methyltransferases.	2.00893e-69
NC_017278.1|WP_014514654.1|261200_261923_+|CRISPR-associated-endoribonuclease-Cas6	gnl|CDD|187783	cd09652, Cas6-I-III, CRISPR/Cas system-associated RAMP superfamily protein Cas6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas6 is an endoribonuclease that generates crRNAs, predicted subunit of Cascade complex; RAMP superfamily protein; Possesses double RRM/ferredoxin fold.	7.33055e-24
NC_017278.1|WP_014514653.1|258920_261158_-|CRISPR-associated-endonuclease-Cas3''	gnl|CDD|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	3.55156e-45
NC_017278.1|WP_014514494.1|270255_271476_+|IS256-family-transposase	gnl|CDD|307151	pfam00872, Transposase_mut, Transposase, Mutator family.	3.90236e-89
NC_017278.1|WP_014514647.1|252907_254017_-|CRISPR-associated-protein-Cmr3	gnl|CDD|187879	cd09748, Cmr3_III-B, CRISPR/Cas system-associated RAMP superfamily protein Cmr3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; This protein is a subunit of Cmr complex.	5.15356e-86
NC_017278.1|WP_081477221.1|276398_276731_-|M48-family-metallopeptidase	gnl|CDD|320703	cd07344, M48_yhfN_like, Peptidase M48 YhfN-like, a novel minigluzincin. M48 YhfN-like protease is considered as a CaaX prenyl protease 1 homolog, with most of the sequences in this family as yet uncharacterized. It contains the zinc metalloprotease motif (HEXXH), likely exposed on the cytoplasmic side. It is probably associated with the endoplasmic reticulum (ER), regardless of whether its genes possess the conventional signal motif (KKXX) in the C-terminal. Proteins in this family proteolytically remove the C-terminal three residues of farnesylated proteins. This novel family of related proteins consist of the soluble minimal scaffold similar to the catalytic domains of the integral-membrane metallopeptidase M48 and M56, thus called minigluzincins.	1.21887e-25
NC_017278.1|WP_014514667.1|283941_284973_-|DNA-replication-and-repair-protein-RecF	gnl|CDD|184491	PRK14079, recF, recombination protein F; Provisional.	5.07879e-143
NC_017278.1|WP_014514661.1|273177_275055_-|DUF262-domain-containing-protein	gnl|CDD|377008	pfam03235, DUF262, Protein of unknown function DUF262.	5.10536e-28
NC_017278.1|WP_014514662.1|275017_276238_-|IS256-family-transposase	gnl|CDD|307151	pfam00872, Transposase_mut, Transposase, Mutator family.	4.12421e-89

Protein sequences

>NC_017278.1|WP_155983240.1|265468_265717_+|CRISPR-associated-endonuclease-Cas2
MVYDVAVERVVKVLKVGRRYLTWVQNSVLEGELSPAQYARLKAEVRKIIEPSDAVRFYLFPNRDSLRIETIGSTKNEPDQFI
>NC_017278.1|WP_081477220.1|264757_265453_+|CRISPR-associated-protein-Cas5
MKGKRAHFRRFYTNSSSLTYPVPPPTTVQGLLAAALGLGEEYLGELRGLWVSARPTAPLRHAFQTVNYLFLKEGKLEELRGLYREGRTQIPVQYLLGEEGRPVAFEVYVASERKGIVEGLGEALANPAYPLALGPAYALAWAEGISILEADLRSHWTGIGLGWWEAGKLRLQGTPLGARLYRDRFPLSLGPGRQPMRIGELALEVRGEPLPVQYEGEVLMLGEVAVGVVQV
>NC_017278.1|WP_014514656.1|263780_264740_+|type-I-B-CRISPR-associated-protein-Cas7/Csh2
MVANAEILYLYEAKDTNPNGDPDAENRPRMDYVGQRLLVSDVRLKRYVRDYLLARGEDVWVRSREDGSRTDADGRLEDLKGLYKEETGRDAGAKKKDLDPEFLAWYLRRLRDVRLFGAVLPIKAEGESKGGTGQFVGAVQFDWGYSLHPVEVYTATISSVFAGRTEGGKGEHGTFGKDHRVHYALIAFWGRVSKRRGEAVGLTSEDLEVLEKGLLEGLLEGATTRSKVGQTPRLYLRVDWKEGFRPMGDPRDGLSIRPVEGKAPEGIRSVRDYVLQAHALSESLNSLRESIARVRLWQHPDLQLEGLNLSGLSLEEVNL
>NC_017278.1|WP_155983239.1|261919_263791_+|hypothetical-protein
MIRQLLRLGQSGGEGFRLEDYVQRASGRLYLLDLDPQNRVAGFTPYELDEEKCARFLWVGDPPASNAPRDRATTKDLRYLLGQVPTRMAEHSGLKSLLQGFLWDPGKPGGKARYLLDLRGWRLQGAKDAEAPPFRIQGGRLEMDGTAEGKTAGELAEALAQVLRAAYDIRSPEKGGVLLFSLALSGKPLAEYPEYGDYLRQRLLQEPFAEAQMGICHGCGRKDRVTGNFSAFRLKFYITDKKSFAPGVDEGAFPRAYALCQTCFAALGVGERLAWERLRQRFLERDVLVLPEADFPQESLERLLERLVGQVQGLERLERWKDFLERAAHRQEEVRYLGFSLLFFQRAQAATKAEELVLEVPPSRVEAILKTLQEARERGFPVEGLRDWLFLMPLSRGRKGEMGQMGLALQAVSRIFLQLPLFPKDLLPLWLKTAERVYREDGTLYALTRYRAGQGVIDLVNLGAGWMWVLQRLEVWGGNMEGEVKGALPLTEEEKPLFEAYGFGALRAGLYLLGQAMEAVGQAQARLSEYRKEPLLDSIGWQGMSLVRVRHLVPEVMAKATYYLEGDDRTRVLDLLGRATDLLERSRESLSEREVPYYILMGYAQARSKRLRSGRREEVTHGG
>NC_017278.1|WP_014514654.1|261200_261923_+|CRISPR-associated-endoribonuclease-Cas6
MPSEGGRLSLRFFAEGRLPVTYREGLQAALYQALPLPLGQRLHDGGLLEGHRPLKLFVFSRLQGLLYLREEKAFLAQGELVLHFASALPEVVEGLAKGVWERGGLEVHGLFLRLLGMDLDPLPEGGDLVVEALSPITAYRTEGGRTLYFNPLNREFALLLEANLVRKAQLLGLEAGSLALKPVGFRPQHKRVERYKDTWIEGWMGRYRLEGSPHLIRLALLTGLGAKNSQGFGFVREVKG
>NC_017278.1|WP_014514653.1|258920_261158_-|CRISPR-associated-endonuclease-Cas3''
MLLARTSPDEPLLEHLLGVGALAEGYLAPLGLGEEGRLAGLCHDLGKATPYFQEMLAGQRAKGDPLTWHALLGALYAAWTARQRGMGEKSLLLFLAVLEHHGSLKTPWERIPLGPRQASEKAWKILPKQIRALQESPLFPALVADLGLPPPEAFLGEGAWEEAERLAREADALLDREGRDLGLHYRLALLYSALLDADRRLAGQAPPKGEGIPIPPEAAEAHLARKSRPTPLSPQREALFRGVGEVLEGPLERVFPARLTLTAPTGAGKTLAALRFALALRERVHRERGFRPKVVYALPYIAIADQVEEEARGVLQAAGLKPEEHLLVHHHLALAREEEGSVEEALLLQETWDAEVVVTTFHQLFPTLVGPGSALRPLHALAKGAILILDEVQTLPAELWPFLGELLRQLPGQMTVISMTATQPGLVKGQEVAPHLPSYPRRVRLAWHGARTLEELGQALLQEGPKSRLVVVNTVREAISLYRFLREEGLPHLYLLTSHIIPKHRKARLGEIRAKLQEGQPLTLVATQVVEAGVDLDFQEGYRAFAPMESILQVAGRVNRSALGEGRLWVLDLEGDGGRRVYGTILLDRSRRVLGPRLAEGLWDLEAYALLPQYYRLVEEGISQAKGQDLLAKLARLDYSQLRFTLIEEAPSIPIFIEWDQEATRLLGELEGALTLKDPGERRKRLRPLLARIQGYTVSPLLQRALKNLPPPLLGREEWRHVPREAVADFYDEEMGFLWEMEQFL
>NC_017278.1|WP_014514650.1|257447_258431_-|type-I-B-CRISPR-associated-endonuclease-Cas1
MPKPVYIFSSGRLSRLANTLVLETEDRKRHLPVEQVSELYLFGEVDLNKRFLEFAAQKGILLHFFNRFGYYVGSFYPREHLLSGYLTLRQAQHYLDANRRLNLARRFVEGGLENIRRLLRKEEAKGKRVSDALDTIGEILSQVKGAQHVGELMALEGRARESYYAVWDELLGEEWSLERNRRPPKDPVNALVSFGNTLLYTAILAQIYQTHLDPRIGFLHEANYRRHSLNLDVAEVFKPVLVDRMIFRLIRRGQIKTGHFLREGQGVFLSEAGKRLVVEEWENSLQATYRHLSLKRSVSYRTTLRLELYKLEKHLIEENPYIPYRFR
>NC_017278.1|WP_014514649.1|255827_256067_-|hypothetical-protein
MAFLRVLEDPVLKAKQVKGLQDLVGVLQSRNQPLLIHGLLVPTEKQVEQVQQLGRELLKALQEEGAPSLELEVLPLERL
>NC_017278.1|WP_014514648.1|254006_255779_-|type-III-B-CRISPR-associated-protein-Cas10/Cmr2
MESLLAISLGPVQDFIATARRTRDLYAGSRLLSEAAGKAAEVLAERLGPERLIFPAPKTKEELAKLGQAGIPNVLLARVSEGLDPGALAEVALGAAREYLREKAKELFTREGRRAYVSLEAALDQVGDLLEGYYAHLPLQGDYPQARERVMALLGARKNTRDFRPVSWGSPAYKSSLDGARESVLLLPESRAEALRVRLRLGLREGEYLSGPDLLKRWWEAEGGFVSTIHMAALPFWEGVRKAGKEGLFRKGLEDLAQLAGEEAKGNTRHPALRDTPFWEWDVRLLYESRLEEFPALGEDPRRLEEARGRLRRLLGELGLGSPGSYYALLHADGDRMGEAIDRQKTPEAHRELSRALALDFAAQVRELVQGRGGGLVYSGGDDVLALLPLHRALETAWALARRFQEVMARFGGGEGKPSLSVGLAVVHHLEPLQDALELARKAERLAKEGPEGTPEDEKRNALGVAYSPRSGSELLVRGRWDETPRLTQRLLRYADLLRAGEVPSRAAHELRELLAWRKGLSEEALVAEALRILGRKAMEKKYRQELSDWIQNARDVERLAQELILARPLAEALDQAGIPVESREVWDAH
>NC_017278.1|WP_014514647.1|252907_254017_-|CRISPR-associated-protein-Cmr3
MLIEPRDPLIVRDGRPFTNSPGARAHSLAFPLPQTLAGAYRARRGMEEGLSFPQDADRVREWGLKGPLLAEEAETGWRLLAPRPLDALKLGERVYALRPLEVPEGAGTNLPQGLFPVGLPKTGLKGKPSPLPAFWYWEDWQRWLLEEAPEGFQPKGHGGPTIEVRTHVSLRPEAGTAREGALFQTSGLEFAYRRGEGDGRPHRLALALWPEDGVEVEGIHPLGGERRLAYWRRGGPPLPPMPSGLLEALWEHRAARIVLLTPAFFRKGYLPEKDAFLGAQVVGAAVGRPVVVSGWDLKKGRPKPTRRAVPPGSVYFVRLPGEWSREEVRAFAEKVWLQNLSEEETDRKDGFGLAALGVWSGKPWRWEEV
>NC_017278.1|WP_014514494.1|270255_271476_+|IS256-family-transposase
MFNRGAHLSTRRCPVDQDTLRILLREAVRETVAEVLQTVLELDRTAFLQVHGGRRNGYYPRKLETTFGQVDLKVPRDRESRYYPAFLKPYVRRLVDVGEVAVALYAAGVSQRKAAEILSLLLGHRYSHETLSALTDEVLEAAGAFRTRPLPEEMAFVYLDGLSLKVFREGEGIVRESVYVALGIAPNGERRVLGFWLLPTESALGWEGVLGELWQRGLRRVLLFITDGLPGLPEAIRRVYPQAEWQRCVVHGVRWSLSQVRARDRGLLAEDLRRVYGAESREEALGALEEVKAAWGSRYPGVVGLWVQDSGAFLRFYGYPKVLWPYLRSTNLMERFIREVRRGTKVRDHKFPKEEAVYKLLYLESERQEGRWAERKLKGFSEVKEVLEKMLQERYAPRTQTLTHNS
>NC_017278.1|WP_014514485.1|271714_272806_+|IS4-family-transposase
MEQLTPLINALKRYWKADLRRLTFLAALVMALVTARTTSGPRLALSLGSIASPDPRSAYRRFQRFLAWPGLDGEGYARFIFALLRPQGLLLVMDRTEWELGKSKVNLLMLAFLYQGLAVPLFWSFLPHDGNSSTPERIALMERALAFLRAHFPHLRVEGFLADREFIGEAWFRYLEEKGIPRCIRIKANTRMWRLGSGPRAWELFASLKVGESRVPRRRYWVYGRRMWVVGLRLGVREWLIVATDLDPHRVLEVYGLRWGIERLFGALKGRGFDLEATHVTRGERLSRLLVPLSLAFVWAFRTGLVLHRVRPVRPKKHGRLGQSLFRAGLDLLTLWALALWGAGGGRRGSPLGLCPMEVLTCT
>NC_017278.1|WP_014514661.1|273177_275055_-|DUF262-domain-containing-protein
MPPVHRLLHITLDTTIDMNGADILLKGLNLKTQKKGGRRQMDNERIQTKVFRIRQLLESSVVYQVPRFQRPYSWSRVHWKTFLEDIENTCHLSKDGMPYLHFLGAIITMARPSGVEVVAPYILVDGQQRLITIALLLAAIRNRAAEAGLSSLSHELDKLLRNADEELELKVQPTEFDEAALRGIIRGTPLEELHSPIGNAYSFFTDKLKGRAPEELEVLAKALLDQTEVVRIHLSQGENAYRIFESLNYKGSPLTPADLVRNYLFMRLAAEGKEKEKETYEKVWAPVEEAYKKVFPPSPANSIPHLERMSLGIWHYVRTNGEEIPWDATYPALIDRLNATLKEGKATESFALELKESLADYLFFERPHLETNPKLQRRLEAFRILGFGVAAPLVMALKQRIRKGVLDIEDADQVLAVMEAYYLHRILASVPTNTVGRTVLSVLKNGLLDEPNPAEKVRRFLKGLSGNRRWPDREELEKRNAERSIYVWDGGGRDPRTSHAYYILKRIEQYLWKKLKRKELPNLENLTLEHIMPRTLSEAWKAEIGIDWERTHKSHLNALGNLTLTGYNQEMGNKPFSEKLKVLRESTLSINQEYFRSVSLERWDEQAIRERTKWLLDLVYEIWPA
>NC_017278.1|WP_014514662.1|275017_276238_-|IS256-family-transposase
MFNRGAHLSTRRCPVDQDTLRILLREAVRETVAEVLQTVLELDRTAFLQVHGGRRNGYYPRKLETTFGQVDLKVPRDRESRYYPAFLKPYVRRLVDVGEVAVALYAAGVSQRKAAEILSLLLGHRYSHETLSALTDEVLEAAGAFRTRPLPEEMAFVYLDGLSLKVFREGEGIVRESVYVALGIAPNGERRVLGFWLLPTESALGWEGVLGELWQRGLRRVLLFITDGLPGLPEAIRRVYPQAEWQRCVVHGVRWSLSQVRARDRGLLAEDLRRVYGAESREEALGALEEVKAAWGSRYPGVVGLWVQDSGAFLRFYGYPKVLWPYLRSTNLMERFIREVRRGTKVRDHKFPKEEAVHKLLYLESERQEGRWAERKLKGFSEVKEVLEKMLQERYAPRTQTLTHNS
>NC_017278.1|WP_081477221.1|276398_276731_-|M48-family-metallopeptidase
MRRGVTKRKEATESAWQPLEEAVPVDVFRAEVLAWAERLGVTPREIRIQPMRRKWASCSSRGRLTFDTALLHQPAEFRREVIVHELLHLSVPNHGKLFRALLKAYLVAKE
>NC_017278.1|WP_014514663.1|276723_279642_-|HsdR-family-type-I-site-specific-deoxyribonuclease
MSISSERRTVQNPLLRYATEAGWTYVPPDEALRLRSGEDKPFLHAVLVEQLQRLNPGVVTHATKAEEVVRRLQALRADIEGNREAWEYLKGLKTIFVEADRRERNLRLLDPDRPEDNRFHVTDEFVFRSGARRIRADVVFFINGIPVLVIETKAATRLEGIAEAFDQIRRYHAEAPDLLVHLQLFALTHLVQFFYGATWSLSRKMLFNWREEHGSGDFETLVKSFLAPRRVMRVLTEYILFARKDGELTKVVLRPHQMRATERVLARAHDPQKRRGLIWHTQGSGKTYTMLTIARRLLEDPRFENPTVLLIVDRNELEQQLFQNLEAIGFSRVHLALSKRHLRELLAADTRGIIVSMIHKFDDMPADLCTRHNVFVLVDEAHRSTGGDLGNYLMGALPNATFIGFTGTPIDRTAHGKGTFKTFGTDDPQGYLDKYSIRESIEDGTTVPLHYQLAPNDLIADREAMEREFWAAAELEGVADIEEINRVLDRAVTLTNMLKNPERVAKIAAFVADHFKQYVQPMGYKAFLVAPDREGCVLYKEALDRHLPSEWSAVVISAGHNDPAHLKRYHLSEDAERRLRQAFRKPGENPQIFIVTEKLLTGYDAPILYCMYLDKPMRDHVLLQAIARVNRPYESEQGQRKTTGLIVDFVGIFDNLERALAFDSQDVSGVVQGIDALKARFAQLMDEGRHTYLPIAAGEVGDKAAEALLEHFRDKDRREAFYQFFRELEEVYEILSPDPFLRPHLNDYQRLAEMYRLLRASYEPHIPVDKSFLRKTATIVQQHTHTSLVHEPSATYEIGAAMLMALLNAEQPDTVKVFNLLKELYRLVEAKGHSAPYLLSIGERAEEIRRRFEERQIESQEALRELNELIRQLRAAEEERRQRGDLAARPHAEQAFTVEWWLRLHNIAPERAKEVADTMEAAFAEFPHWMSDRRQEGELRKCLYKALFAISVSDVVAWTNAILDLLRRATDA
>NC_017278.1|WP_081477222.1|279638_280916_-|restriction-endonuclease-subunit-S
MRCTNPDTLPDGYRMTELGPLPEEWQVVRLGEVGKVITGRTPPTSQARFWNGHIPFITPVDLQGKPIRHSERSITEEGLQHAKPLPRGAVLVSCIGYIGKIGIVEAELATTNQQINAVIPFGCDNWFLAYALMHETDVLRSRARMTTVPILHKSNFENIPIPFPPLTEQRAIAHVLRTVQAAKEAGERVVEALRALKKSLMRHLFTYGPVPIDAAEHVPLRDTELGPLPAHWQVVRLGEVAEVKYGRAKPKAEGEIPVIGSGGIYGWADAPLVEFPTLVIGRKGTAGQVWLVEQACWPSDTTYYLIWKKPVDVWFVFGFVSLNPLSGEHARTTLPSLKRHDLENYLIPLPPLPEQREIARMLQAVDQRIQAEEAHVHALEALFRTLLHELMTARRRLPAEFIAKFASHGDQTLRAATPTIEERSL
>NC_017278.1|WP_014514665.1|280912_282481_-|type-I-restriction-modification-system-subunit-M
MDLTTLENWLWEAACAIRGPVDAPKFKDYILPLIFLKRLSDVFEDELRSLAVEFGGIDVAQNLVEQERAHGKVTLVRFYIPENARWETVRRQTSHLGEYLTDAVRALARENPVLAGVIDIVDFNATAAGQRIVPDEYLARLINVLSRYRLGLGDVEPDILGRAYEYLLRKFAEDQGQSAGEFYTPREVGVLMARLLEPEPGMMVYDPTCGSGGLLIKCHLRLLERFGKQENGRLKLPTNIAPLHVFGQEINPATFAIARMNAVIHDIQADIRIGDTMRQPAFKGQGGGLQTFDLVVANPMWNQKFPQELYKNDPYNRFCYGAPPSSSADWGWLQHMLASLNERGRMAVVLDTGAVSRGSGNQGSNRERDIRKAFVEADLIEAVILLPENLFYNTTAPGVIIVVNRRKRYPGQILLINASQLFAKGRPKNYLTEEHIETIASIYHAWGDPAGANRDAPLHAIITREEAARNDYNLSPSRYVSISGSEEVLPLEEALVRLEEAEEERAEAERALQAVLQQLGLR
>NC_017278.1|WP_041433934.1|283204_283957_-|DUF721-domain-containing-protein
MPWRLKEVLPEALKRAGGKERLQRGLVLASWKEVVGRELARLTEAVALEEGVLTVWVADPVTAHQLTYSRLALLRRYEERFPGKVREIRFLVGRLEAPSPEPPPPPKDPEAGRKALALAQLAPSELREAVARAAFALFAHKRGNPCPLCGTPSETHPCPTCRRLLESPLVRKEAERLKRGRPPRLEGEALLVARHLARERLLAEMRELYPQALREAGLRPLLRDLARRFQSLFPEEALPEGVQSLLAKED
>NC_017278.1|WP_014514667.1|283941_284973_-|DNA-replication-and-repair-protein-RecF
MRLRLFRQKGFRNLYLETFHPPPVPFAVVGGNAQGKTSLLLGVHLLLGGEVRASLADLVRFGEREAWLYGEVETELGRYRVEQRLFPEGREIRVNGKAVGLKGLWELPGSVLLLPEDVEVVLGPKEERRGFLDRMIGRFSRRYAALLSAYEKVLRQRNALLKAGGNGLSVWDRELARYGTEIMAFRRRFLRRFLPTFQEVHRSLAPGEVGLALEESAQGDFLEALEQRRPEELLRGQTLLGPHRDDLVFLLAGRPAHRFASRGEAKALALALRLAEHRLLWEHHGEAPLLLVDEWSEELDPGRRKALLTYAQGLPQAILAGLQTPEGMPVCSMAGGVVLCPGG

Crispr_ID: NC_017278_4

• CRISPR_ID: NC_017278_4
• CRISPR_location: 268040-269753
• CRISPR_type: TypeIII
• Repeat_type: NA
• Spacer_info: 25 spacers
• Cas_protein_info: cas2,cas5,cas7,cas8b1,cas6,cas3,cas1,cas10,cmr3gr5

Consensus repeat of NC_017278_4

Consensus_repeat	Method
NNCTTTGAACCGTACCTATAAGGGTTTGAAAC	CRT
GTTTCAAACCCTTATAGGTACGGTTCAAAG	PILER-CR
CTTTGAACCGTACCTATAAGGGTTTGAAAC	CRISPRCasFinder

spacers of NC_017278_4

>4.1|268070|39|NC_017278|CRT
TTGCCGTTCTCCATCTTTTTCCTGCGTGGGCTCCCAATG
>4.2|268139|37|NC_017278|CRT,PILER-CR,CRISPRCasFinder
CGTTTCCACTATTATGGCTTGGACCCGTGGGCTCGGG
>4.3|268206|36|NC_017278|CRT,PILER-CR,CRISPRCasFinder
GTGGAGAGCTTGGACCCGGGGGCGGCCGCCAGCCAC
>4.4|268272|38|NC_017278|CRT,PILER-CR,CRISPRCasFinder
TGGGGGCTATGGTATCATCGGCCCACGGGGAGAACAGG
>4.5|268340|36|NC_017278|CRT,PILER-CR,CRISPRCasFinder
CTACCACAGGCTGGATGGTACCGCTCCCGCACGGAG
>4.6|268406|38|NC_017278|CRT,PILER-CR,CRISPRCasFinder
CCTCTTCATCTTCATCCTTATCCCCCCTTTACACCCTC
>4.7|268474|37|NC_017278|CRT,PILER-CR,CRISPRCasFinder
TCGGGGAGGAGGCTTCAGAGTTCGGCATAGTGCTAAT
>4.8|268541|40|NC_017278|CRT,PILER-CR,CRISPRCasFinder
TCCTCCGAGAGGATGGCGTAGATGTGCTCCTCCCGGACCA
>4.9|268611|35|NC_017278|CRT,PILER-CR,CRISPRCasFinder
GAAGCCCAGCGTAAAAAAGAAAAATTTAAAAGCTA
>4.10|268676|38|NC_017278|CRT,PILER-CR,CRISPRCasFinder
TGCCCCCCAGGAGTTTGAGGGGGCGTGAGGTTGAGGAG
>4.11|268744|38|NC_017278|CRT,PILER-CR,CRISPRCasFinder
TAGATTAGAACTAGACCAAACTCGGTCTCCTCCTCAGA
>4.12|268812|39|NC_017278|CRT,PILER-CR,CRISPRCasFinder
TCGGGCCGAGATAAACATCAGCCCGCTCCCATTCTTCCT
>4.13|268881|36|NC_017278|CRT,PILER-CR,CRISPRCasFinder
GGAAAGGATCAAGACGGCCAAGGGGCGCAAGACCAA
>4.14|268947|38|NC_017278|CRT,PILER-CR,CRISPRCasFinder
TGGGGTCTAACTGACCCTGTACCCCCATGGTGCCACGG
>4.15|269015|36|NC_017278|CRT,PILER-CR,CRISPRCasFinder
AATGAGTTCTATGGCTTTCTCTTCCATCCTTTCACT
>4.16|269081|40|NC_017278|CRT,PILER-CR,CRISPRCasFinder
TCGTGAGGTCGGCGTACCTCGGGAGGACTAGACTAGGCTA
>4.17|269151|37|NC_017278|CRT,PILER-CR,CRISPRCasFinder
CCTAACCTGCCTAGCCTGCTTGCCTAACCCGCCTAGC
>4.18|269218|36|NC_017278|CRT,PILER-CR,CRISPRCasFinder
AAAAGATTTGGGACATGCTCCAGCAGGCTATTCAGG
>4.19|269284|37|NC_017278|CRT,PILER-CR,CRISPRCasFinder
AGCCCGCCCCCCTTTAGGGTGGACCTAGTCTGCTAGG
>4.20|269351|37|NC_017278|CRT,PILER-CR,CRISPRCasFinder
CGCTTCCCCCCTCCCGCATAAATCTTTCCCATTGCCT
>4.21|269418|36|NC_017278|CRT,PILER-CR,CRISPRCasFinder
CTGGGGGTGCGGGGAAGACCTCCCTGGCCCGGGACC
>4.22|269484|40|NC_017278|CRT,PILER-CR,CRISPRCasFinder
GGTGCGCCGCACTCCTTTCGTCTAAGAGGTCCCGCATCCG
>4.23|269554|36|NC_017278|CRT,PILER-CR,CRISPRCasFinder
TCAGAAGCCAAACAACAGAAAGAACTATCATCAGGC
>4.24|269620|36|NC_017278|CRT,PILER-CR,CRISPRCasFinder
GCTGCCCGGTACACTTCTGGGCCTCGGGTGGCCCAG
>4.25|269686|38|NC_017278|CRT
CTTGGAAGCGCTGGACCGCCCAGGGTGAGGGAGGCTGT

CRISPR arrays and Neighbor proteins around NC_017278_4

CRISPR arrays

The CRISPR arrays of NC_017278_4

>merge|NC_017278|4|268040-269753|CRT,PILER-CR,CRISPRCasFinder
CGTTTTGACGTGTACTGAGGGGTTTGAAACTTGCCGTTCTCCATCTTTTTCCTGCGTGGGCTCCCAATGCTTTGAACCGTACCTATAAGGGTTTGAAACCGTTTCCACTATTATGGCTTGGACCCGTGGGCTCGGGCTTTGAACCGTACCTATAAGGGTTTGAAACGTGGAGAGCTTGGACCCGGGGGCGGCCGCCAGCCACCTTTGAACCGTACCTATAAGGGTTTGAAACTGGGGGCTATGGTATCATCGGCCCACGGGGAGAACAGGCTTTGAACCGTACCTATAAGGGTTTGAAACCTACCACAGGCTGGATGGTACCGCTCCCGCACGGAGCTTTGAACCGTACCTATAAGGGTTTGAAACCCTCTTCATCTTCATCCTTATCCCCCCTTTACACCCTCCTTTGAACCGTACCTATAAGGGTTTGAAACTCGGGGAGGAGGCTTCAGAGTTCGGCATAGTGCTAATCTTTGAACCGTACCTATAAGGGTTTGAAACTCCTCCGAGAGGATGGCGTAGATGTGCTCCTCCCGGACCACTTTGAACCGTACCTATAAGGGTTTGAAACGAAGCCCAGCGTAAAAAAGAAAAATTTAAAAGCTACTTTGAACCGTACCTATAAGGGTTTGAAACTGCCCCCCAGGAGTTTGAGGGGGCGTGAGGTTGAGGAGCTTTGAACCGTACCTATAAGGGTTTGAAACTAGATTAGAACTAGACCAAACTCGGTCTCCTCCTCAGACTTTGAACCGTACCTATAAGGGTTTGAAACTCGGGCCGAGATAAACATCAGCCCGCTCCCATTCTTCCTCTTTGAACCGTACCTATAAGGGTTTGAAACGGAAAGGATCAAGACGGCCAAGGGGCGCAAGACCAACTTTGAACCGTACCTATAAGGGTTTGAAACTGGGGTCTAACTGACCCTGTACCCCCATGGTGCCACGGCTTTGAACCGTACCTATAAGGGTTTGAAACAATGAGTTCTATGGCTTTCTCTTCCATCCTTTCACTCTTTGAACCGTACCTATAAGGGTTTGAAACTCGTGAGGTCGGCGTACCTCGGGAGGACTAGACTAGGCTACTTTGAACCGTACCTATAAGGGTTTGAAACCCTAACCTGCCTAGCCTGCTTGCCTAACCCGCCTAGCCTTTGAACCGTACCTATAAGGGTTTGAAACAAAAGATTTGGGACATGCTCCAGCAGGCTATTCAGGCTTTGAACCGTACCTATAAGGGTTTGAAACAGCCCGCCCCCCTTTAGGGTGGACCTAGTCTGCTAGGCTTTGAACCGTACCTATAAGGGTTTGAAACCGCTTCCCCCCTCCCGCATAAATCTTTCCCATTGCCTCTTTGAACCGTACCTATAAGGGTTTGAAACCTGGGGGTGCGGGGAAGACCTCCCTGGCCCGGGACCCTTTGAACCGTACCTATAAGGGTTTGAAACGGTGCGCCGCACTCCTTTCGTCTAAGAGGTCCCGCATCCGCTTTGAACCATACCTATAAGGGTTTGAAACTCAGAAGCCAAACAACAGAAAGAACTATCATCAGGCCTTTGAACCGTACCTATAAGGGTTTGAAACGCTGCCCGGTACACTTCTGGGCCTCGGGTGGCCCAGCTTTGAACCGTACCTATAAGGGTTTGAAATCTTGGAAGCGCTGGACCGCCCAGGGTGAGGGAGGCTGTCTTTGAACCCTACCTATGAGTTGACTGCAT

>NC_017278|4|4|268040-269753|CRT
CGTTTTGACGTGTACTGAGGGGTTTGAAAC	TTGCCGTTCTCCATCTTTTTCCTGCGTGGGCTCCCAATG
CTTTGAACCGTACCTATAAGGGTTTGAAAC	CGTTTCCACTATTATGGCTTGGACCCGTGGGCTCGGG
CTTTGAACCGTACCTATAAGGGTTTGAAAC	GTGGAGAGCTTGGACCCGGGGGCGGCCGCCAGCCAC
CTTTGAACCGTACCTATAAGGGTTTGAAAC	TGGGGGCTATGGTATCATCGGCCCACGGGGAGAACAGG
CTTTGAACCGTACCTATAAGGGTTTGAAAC	CTACCACAGGCTGGATGGTACCGCTCCCGCACGGAG
CTTTGAACCGTACCTATAAGGGTTTGAAAC	CCTCTTCATCTTCATCCTTATCCCCCCTTTACACCCTC
CTTTGAACCGTACCTATAAGGGTTTGAAAC	TCGGGGAGGAGGCTTCAGAGTTCGGCATAGTGCTAAT
CTTTGAACCGTACCTATAAGGGTTTGAAAC	TCCTCCGAGAGGATGGCGTAGATGTGCTCCTCCCGGACCA
CTTTGAACCGTACCTATAAGGGTTTGAAAC	GAAGCCCAGCGTAAAAAAGAAAAATTTAAAAGCTA
CTTTGAACCGTACCTATAAGGGTTTGAAAC	TGCCCCCCAGGAGTTTGAGGGGGCGTGAGGTTGAGGAG
CTTTGAACCGTACCTATAAGGGTTTGAAAC	TAGATTAGAACTAGACCAAACTCGGTCTCCTCCTCAGA
CTTTGAACCGTACCTATAAGGGTTTGAAAC	TCGGGCCGAGATAAACATCAGCCCGCTCCCATTCTTCCT
CTTTGAACCGTACCTATAAGGGTTTGAAAC	GGAAAGGATCAAGACGGCCAAGGGGCGCAAGACCAA
CTTTGAACCGTACCTATAAGGGTTTGAAAC	TGGGGTCTAACTGACCCTGTACCCCCATGGTGCCACGG
CTTTGAACCGTACCTATAAGGGTTTGAAAC	AATGAGTTCTATGGCTTTCTCTTCCATCCTTTCACT
CTTTGAACCGTACCTATAAGGGTTTGAAAC	TCGTGAGGTCGGCGTACCTCGGGAGGACTAGACTAGGCTA
CTTTGAACCGTACCTATAAGGGTTTGAAAC	CCTAACCTGCCTAGCCTGCTTGCCTAACCCGCCTAGC
CTTTGAACCGTACCTATAAGGGTTTGAAAC	AAAAGATTTGGGACATGCTCCAGCAGGCTATTCAGG
CTTTGAACCGTACCTATAAGGGTTTGAAAC	AGCCCGCCCCCCTTTAGGGTGGACCTAGTCTGCTAGG
CTTTGAACCGTACCTATAAGGGTTTGAAAC	CGCTTCCCCCCTCCCGCATAAATCTTTCCCATTGCCT
CTTTGAACCGTACCTATAAGGGTTTGAAAC	CTGGGGGTGCGGGGAAGACCTCCCTGGCCCGGGACC
CTTTGAACCGTACCTATAAGGGTTTGAAAC	GGTGCGCCGCACTCCTTTCGTCTAAGAGGTCCCGCATCCG
CTTTGAACCATACCTATAAGGGTTTGAAAC	TCAGAAGCCAAACAACAGAAAGAACTATCATCAGGC
CTTTGAACCGTACCTATAAGGGTTTGAAAC	GCTGCCCGGTACACTTCTGGGCCTCGGGTGGCCCAG
CTTTGAACCGTACCTATAAGGGTTTGAAAT	CTTGGAAGCGCTGGACCGCCCAGGGTGAGGGAGGCTGT
CTTTGAACCCTACCTATGAGTTGACTGCAT

>NC_017278|4|4|268109-269685|PILER-CR
CTTTGAACCGTACCTATAAGGGTTTGAAAC	CGTTTCCACTATTATGGCTTGGACCCGTGGGCTCGGG
CTTTGAACCGTACCTATAAGGGTTTGAAAC	GTGGAGAGCTTGGACCCGGGGGCGGCCGCCAGCCAC
CTTTGAACCGTACCTATAAGGGTTTGAAAC	TGGGGGCTATGGTATCATCGGCCCACGGGGAGAACAGG
CTTTGAACCGTACCTATAAGGGTTTGAAAC	CTACCACAGGCTGGATGGTACCGCTCCCGCACGGAG
CTTTGAACCGTACCTATAAGGGTTTGAAAC	CCTCTTCATCTTCATCCTTATCCCCCCTTTACACCCTC
CTTTGAACCGTACCTATAAGGGTTTGAAAC	TCGGGGAGGAGGCTTCAGAGTTCGGCATAGTGCTAAT
CTTTGAACCGTACCTATAAGGGTTTGAAAC	TCCTCCGAGAGGATGGCGTAGATGTGCTCCTCCCGGACCA
CTTTGAACCGTACCTATAAGGGTTTGAAAC	GAAGCCCAGCGTAAAAAAGAAAAATTTAAAAGCTA
CTTTGAACCGTACCTATAAGGGTTTGAAAC	TGCCCCCCAGGAGTTTGAGGGGGCGTGAGGTTGAGGAG
CTTTGAACCGTACCTATAAGGGTTTGAAAC	TAGATTAGAACTAGACCAAACTCGGTCTCCTCCTCAGA
CTTTGAACCGTACCTATAAGGGTTTGAAAC	TCGGGCCGAGATAAACATCAGCCCGCTCCCATTCTTCCT
CTTTGAACCGTACCTATAAGGGTTTGAAAC	GGAAAGGATCAAGACGGCCAAGGGGCGCAAGACCAA
CTTTGAACCGTACCTATAAGGGTTTGAAAC	TGGGGTCTAACTGACCCTGTACCCCCATGGTGCCACGG
CTTTGAACCGTACCTATAAGGGTTTGAAAC	AATGAGTTCTATGGCTTTCTCTTCCATCCTTTCACT
CTTTGAACCGTACCTATAAGGGTTTGAAAC	TCGTGAGGTCGGCGTACCTCGGGAGGACTAGACTAGGCTA
CTTTGAACCGTACCTATAAGGGTTTGAAAC	CCTAACCTGCCTAGCCTGCTTGCCTAACCCGCCTAGC
CTTTGAACCGTACCTATAAGGGTTTGAAAC	AAAAGATTTGGGACATGCTCCAGCAGGCTATTCAGG
CTTTGAACCGTACCTATAAGGGTTTGAAAC	AGCCCGCCCCCCTTTAGGGTGGACCTAGTCTGCTAGG
CTTTGAACCGTACCTATAAGGGTTTGAAAC	CGCTTCCCCCCTCCCGCATAAATCTTTCCCATTGCCT
CTTTGAACCGTACCTATAAGGGTTTGAAAC	CTGGGGGTGCGGGGAAGACCTCCCTGGCCCGGGACC
CTTTGAACCGTACCTATAAGGGTTTGAAAC	GGTGCGCCGCACTCCTTTCGTCTAAGAGGTCCCGCATCCG
CTTTGAACCATACCTATAAGGGTTTGAAAC	TCAGAAGCCAAACAACAGAAAGAACTATCATCAGGC
CTTTGAACCGTACCTATAAGGGTTTGAAAC	GCTGCCCGGTACACTTCTGGGCCTCGGGTGGCCCAG
CTTTGAACCGTACCTATAAGGGTTTGAAAT

>NC_017278|4|4|268109-269685|CRISPRCasFinder
CTTTGAACCGTACCTATAAGGGTTTGAAAC	CGTTTCCACTATTATGGCTTGGACCCGTGGGCTCGGG
CTTTGAACCGTACCTATAAGGGTTTGAAAC	GTGGAGAGCTTGGACCCGGGGGCGGCCGCCAGCCAC
CTTTGAACCGTACCTATAAGGGTTTGAAAC	TGGGGGCTATGGTATCATCGGCCCACGGGGAGAACAGG
CTTTGAACCGTACCTATAAGGGTTTGAAAC	CTACCACAGGCTGGATGGTACCGCTCCCGCACGGAG
CTTTGAACCGTACCTATAAGGGTTTGAAAC	CCTCTTCATCTTCATCCTTATCCCCCCTTTACACCCTC
CTTTGAACCGTACCTATAAGGGTTTGAAAC	TCGGGGAGGAGGCTTCAGAGTTCGGCATAGTGCTAAT
CTTTGAACCGTACCTATAAGGGTTTGAAAC	TCCTCCGAGAGGATGGCGTAGATGTGCTCCTCCCGGACCA
CTTTGAACCGTACCTATAAGGGTTTGAAAC	GAAGCCCAGCGTAAAAAAGAAAAATTTAAAAGCTA
CTTTGAACCGTACCTATAAGGGTTTGAAAC	TGCCCCCCAGGAGTTTGAGGGGGCGTGAGGTTGAGGAG
CTTTGAACCGTACCTATAAGGGTTTGAAAC	TAGATTAGAACTAGACCAAACTCGGTCTCCTCCTCAGA
CTTTGAACCGTACCTATAAGGGTTTGAAAC	TCGGGCCGAGATAAACATCAGCCCGCTCCCATTCTTCCT
CTTTGAACCGTACCTATAAGGGTTTGAAAC	GGAAAGGATCAAGACGGCCAAGGGGCGCAAGACCAA
CTTTGAACCGTACCTATAAGGGTTTGAAAC	TGGGGTCTAACTGACCCTGTACCCCCATGGTGCCACGG
CTTTGAACCGTACCTATAAGGGTTTGAAAC	AATGAGTTCTATGGCTTTCTCTTCCATCCTTTCACT
CTTTGAACCGTACCTATAAGGGTTTGAAAC	TCGTGAGGTCGGCGTACCTCGGGAGGACTAGACTAGGCTA
CTTTGAACCGTACCTATAAGGGTTTGAAAC	CCTAACCTGCCTAGCCTGCTTGCCTAACCCGCCTAGC
CTTTGAACCGTACCTATAAGGGTTTGAAAC	AAAAGATTTGGGACATGCTCCAGCAGGCTATTCAGG
CTTTGAACCGTACCTATAAGGGTTTGAAAC	AGCCCGCCCCCCTTTAGGGTGGACCTAGTCTGCTAGG
CTTTGAACCGTACCTATAAGGGTTTGAAAC	CGCTTCCCCCCTCCCGCATAAATCTTTCCCATTGCCT
CTTTGAACCGTACCTATAAGGGTTTGAAAC	CTGGGGGTGCGGGGAAGACCTCCCTGGCCCGGGACC
CTTTGAACCGTACCTATAAGGGTTTGAAAC	GGTGCGCCGCACTCCTTTCGTCTAAGAGGTCCCGCATCCG
CTTTGAACCATACCTATAAGGGTTTGAAAC	TCAGAAGCCAAACAACAGAAAGAACTATCATCAGGC
CTTTGAACCGTACCTATAAGGGTTTGAAAC	GCTGCCCGGTACACTTCTGGGCCTCGGGTGGCCCAG
CTTTGAACCGTACCTATAAGGGTTTGAAAT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_017278.1|WP_014514649.1|255827_256067_-|hypothetical-protein	unknown	unknown	gnl|CDD|378236
NC_017278.1|WP_155983240.1|265468_265717_+|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|187856
NC_017278.1|WP_041433934.1|283204_283957_-|DUF721-domain-containing-protein	unknown	unknown	gnl|CDD|377496
NC_017278.1|WP_014514663.1|276723_279642_-|HsdR-family-type-I-site-specific-deoxyribonuclease	unknown	unknown	gnl|CDD|273028
NC_017278.1|WP_014514648.1|254006_255779_-|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	cas10	cls000742_cas10_CAS-III	gnl|CDD|274208
NC_017278.1|WP_014514665.1|280912_282481_-|type-I-restriction-modification-system-subunit-M	unknown	unknown	gnl|CDD|223363
NC_017278.1|WP_155983239.1|261919_263791_+|hypothetical-protein	cas8b1	pfam09484_cas8b1_CAS-I-B	gnl|CDD|378190
NC_017278.1|WP_014514650.1|257447_258431_-|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl|CDD|187853
NC_017278.1|WP_014514485.1|271714_272806_+|IS4-family-transposase	unknown	unknown	gnl|CDD|376573
NC_017278.1|WP_014514656.1|263780_264740_+|type-I-B-CRISPR-associated-protein-Cas7/Csh2	cas7	cd09690_cas7_CAS-I-B	gnl|CDD|187821
NC_017278.1|WP_081477220.1|264757_265453_+|CRISPR-associated-protein-Cas5	cas5	mkCas0191_cas5_CAS-I-B	gnl|CDD|187823
NC_017278.1|WP_081477222.1|279638_280916_-|restriction-endonuclease-subunit-S	unknown	unknown	gnl|CDD|341175
NC_017278.1|WP_014514654.1|261200_261923_+|CRISPR-associated-endoribonuclease-Cas6	cas6	pfam01881_cas6_CAS-I:CAS-III	gnl|CDD|187783
NC_017278.1|WP_014514653.1|258920_261158_-|CRISPR-associated-endonuclease-Cas3''	cas3	COG1203_cas3_CAS-I	gnl|CDD|224124
NC_017278.1|WP_014514494.1|270255_271476_+|IS256-family-transposase	unknown	unknown	gnl|CDD|307151
NC_017278.1|WP_014514647.1|252907_254017_-|CRISPR-associated-protein-Cmr3	cmr3gr5	cd09748_cmr3gr5_CAS-III-B	gnl|CDD|187879
NC_017278.1|WP_081477221.1|276398_276731_-|M48-family-metallopeptidase	unknown	unknown	gnl|CDD|320703
NC_017278.1|WP_014514667.1|283941_284973_-|DNA-replication-and-repair-protein-RecF	unknown	unknown	gnl|CDD|184491
NC_017278.1|WP_014514661.1|273177_275055_-|DUF262-domain-containing-protein	unknown	unknown	gnl|CDD|377008
NC_017278.1|WP_014514662.1|275017_276238_-|IS256-family-transposase	unknown	unknown	gnl|CDD|307151

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_017278.1|WP_014514656.1|263780_264740_+|type-I-B-CRISPR-associated-protein-Cas7/Csh2	cas7	cd09690_cas7_CAS-I-B	2.6e-64	212.0	0.0
NC_017278.1|WP_155983240.1|265468_265717_+|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	5.8e-23	75.7	0.0
NC_017278.1|WP_014514648.1|254006_255779_-|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	cas10	cls000742_cas10_CAS-III	2.5e-105	347.9	0.0
NC_017278.1|WP_014514654.1|261200_261923_+|CRISPR-associated-endoribonuclease-Cas6	cas6	pfam01881_cas6_CAS-I:CAS-III	3e-24	80.9	0.0
NC_017278.1|WP_014514653.1|258920_261158_-|CRISPR-associated-endonuclease-Cas3''	cas3	COG1203_cas3_CAS-I	5.8e-48	158.4	0.0
NC_017278.1|WP_081477220.1|264757_265453_+|CRISPR-associated-protein-Cas5	cas5	mkCas0191_cas5_CAS-I-B	1.3e-105	346.1	3.7
NC_017278.1|WP_014514647.1|252907_254017_-|CRISPR-associated-protein-Cmr3	cmr3gr5	cd09748_cmr3gr5_CAS-III-B	3.1e-92	304.4	5.8
NC_017278.1|WP_155983239.1|261919_263791_+|hypothetical-protein	cas8b1	pfam09484_cas8b1_CAS-I-B	2.9e-49	162.9	0.0
NC_017278.1|WP_014514650.1|257447_258431_-|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	3.8e-127	418.6	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_017278.1|WP_014514649.1|255827_256067_-|hypothetical-protein	gnl|CDD|378236	pfam09670, Cas_Cas02710, CRISPR-associated protein (Cas_Cas02710). Members of this family are found, exclusively in the vicinity of CRISPR repeats and other CRISPR-associated (cas) genes, in Methanothermobacter thermautotrophicus (Methanobacterium thermoformicicum), Thermus thermophilus (Deinococcus-Thermus), Chloroflexus aurantiacus (Chloroflexi), and Thermomicrobium roseum (Thermomicrobia).	0.00159673
NC_017278.1|WP_155983240.1|265468_265717_+|CRISPR-associated-endonuclease-Cas2	gnl|CDD|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	5.38647e-24
NC_017278.1|WP_041433934.1|283204_283957_-|DUF721-domain-containing-protein	gnl|CDD|377496	pfam05258, DUF721, Protein of unknown function (DUF721). This family contains several actinomycete proteins of unknown function.	4.91676e-16
NC_017278.1|WP_014514663.1|276723_279642_-|HsdR-family-type-I-site-specific-deoxyribonuclease	gnl|CDD|273028	TIGR00348, R_protein, type I site-specific deoxyribonuclease, HsdR family. This gene is part of the type I restriction and modification system which is composed of three polypeptides R (restriction endonuclease), M (modification) and S (specificity). This group of enzymes recognize specific short DNA sequences and have an absolute requirement for ATP (or dATP) and S-adenosyl-L-methionine. They also catalyse the reactions of EC 2.1.1.72 and EC 2.1.1.73, with similar site specificity.(J. Mol. Biol. 271 (3), 342-348 (1997)). Members of this family are assumed to differ from each other in DNA site specificity. [DNA metabolism, Restriction/modification].	1.68417e-143
NC_017278.1|WP_014514648.1|254006_255779_-|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	gnl|CDD|274208	TIGR02577, thermophile-specific_DNA_repair_system, CRISPR-associated protein Cas10/Cmr2, subtype III-B. This model represent a Crm2 family of the CRISPR-associated RAMP module, a set of six genes recurring found together in prokaryotic genomes. This gene cluster is found only in species with CRISPR repeats, usually near the repeats themselves. Because most of the six (but not this family) contain RAMP domains, and because its appearance in a genome appears to depend on other CRISPR-associated Cas genes, the set is designated the CRISPR RAMP module. This protein, typified by TM1794 from Thermotoga maritima, is designated Crm2, for CRISPR RAMP Module protein 2.	4.04499e-100
NC_017278.1|WP_014514665.1|280912_282481_-|type-I-restriction-modification-system-subunit-M	gnl|CDD|223363	COG0286, HsdM, Type I restriction-modification system methyltransferase subunit [Defense mechanisms].	1.56208e-108
NC_017278.1|WP_155983239.1|261919_263791_+|hypothetical-protein	gnl|CDD|378190	pfam09484, Cas_TM1802, CRISPR-associated protein TM1802 (cas_TM1802). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This minor cas protein is found in at least five prokaryotic genomes: Methanosarcina mazei, Sulfurihydrogenibium azorense, Thermotoga maritima, Carboxydothermus hydrogenoformans, and Dictyoglomus thermophilum, the first of which is archaeal while the rest are bacterial.	3.44437e-48
NC_017278.1|WP_014514650.1|257447_258431_-|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl|CDD|187853	cd09722, Cas1_I-B, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	4.95502e-156
NC_017278.1|WP_014514485.1|271714_272806_+|IS4-family-transposase	gnl|CDD|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	2.41744e-09
NC_017278.1|WP_014514656.1|263780_264740_+|type-I-B-CRISPR-associated-protein-Cas7/Csh2	gnl|CDD|187821	cd09690, Cas7_I-B, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Csh2 family.	6.90831e-60
NC_017278.1|WP_081477220.1|264757_265453_+|CRISPR-associated-protein-Cas5	gnl|CDD|187823	cd09692, Cas5_I-B, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex.	6.84885e-13
NC_017278.1|WP_081477222.1|279638_280916_-|restriction-endonuclease-subunit-S	gnl|CDD|341175	cd17286, RMtype1_S_Lla161ORF747P_TRD1-CR1_like, Type I restriction-modification system specificity (S) subunit TRD-CR, similar to Lactococcus lactis subsp. lactis Dephy 1 S subunit (S.Lla161ORF747P) TRD1-CR1, and Lactococcus lactis IO-1 S subunit (S2.LlaIO1ORF1141P) TRD2-CR2. The recognition sequences of Lactococcus lactis subsp. lactis Dephy 1 S subunit (S.Lla161ORF747P) and Lactococcus lactis IO-1 S subunit (S2.LlaIO1ORF1141P) are undetermined. The restriction-modification (RM) system S subunit consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one heteromeric enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. It may also include TRD-CR-like sequence-recognition domains of various type II restriction enzymes and methyltransferases and type I DNA methyltransferases.	2.00893e-69
NC_017278.1|WP_014514654.1|261200_261923_+|CRISPR-associated-endoribonuclease-Cas6	gnl|CDD|187783	cd09652, Cas6-I-III, CRISPR/Cas system-associated RAMP superfamily protein Cas6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas6 is an endoribonuclease that generates crRNAs, predicted subunit of Cascade complex; RAMP superfamily protein; Possesses double RRM/ferredoxin fold.	7.33055e-24
NC_017278.1|WP_014514653.1|258920_261158_-|CRISPR-associated-endonuclease-Cas3''	gnl|CDD|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	3.55156e-45
NC_017278.1|WP_014514494.1|270255_271476_+|IS256-family-transposase	gnl|CDD|307151	pfam00872, Transposase_mut, Transposase, Mutator family.	3.90236e-89
NC_017278.1|WP_014514647.1|252907_254017_-|CRISPR-associated-protein-Cmr3	gnl|CDD|187879	cd09748, Cmr3_III-B, CRISPR/Cas system-associated RAMP superfamily protein Cmr3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; This protein is a subunit of Cmr complex.	5.15356e-86
NC_017278.1|WP_081477221.1|276398_276731_-|M48-family-metallopeptidase	gnl|CDD|320703	cd07344, M48_yhfN_like, Peptidase M48 YhfN-like, a novel minigluzincin. M48 YhfN-like protease is considered as a CaaX prenyl protease 1 homolog, with most of the sequences in this family as yet uncharacterized. It contains the zinc metalloprotease motif (HEXXH), likely exposed on the cytoplasmic side. It is probably associated with the endoplasmic reticulum (ER), regardless of whether its genes possess the conventional signal motif (KKXX) in the C-terminal. Proteins in this family proteolytically remove the C-terminal three residues of farnesylated proteins. This novel family of related proteins consist of the soluble minimal scaffold similar to the catalytic domains of the integral-membrane metallopeptidase M48 and M56, thus called minigluzincins.	1.21887e-25
NC_017278.1|WP_014514667.1|283941_284973_-|DNA-replication-and-repair-protein-RecF	gnl|CDD|184491	PRK14079, recF, recombination protein F; Provisional.	5.07879e-143
NC_017278.1|WP_014514661.1|273177_275055_-|DUF262-domain-containing-protein	gnl|CDD|377008	pfam03235, DUF262, Protein of unknown function DUF262.	5.10536e-28
NC_017278.1|WP_014514662.1|275017_276238_-|IS256-family-transposase	gnl|CDD|307151	pfam00872, Transposase_mut, Transposase, Mutator family.	4.12421e-89

Protein sequences

>NC_017278.1|WP_155983240.1|265468_265717_+|CRISPR-associated-endonuclease-Cas2
MVYDVAVERVVKVLKVGRRYLTWVQNSVLEGELSPAQYARLKAEVRKIIEPSDAVRFYLFPNRDSLRIETIGSTKNEPDQFI
>NC_017278.1|WP_081477220.1|264757_265453_+|CRISPR-associated-protein-Cas5
MKGKRAHFRRFYTNSSSLTYPVPPPTTVQGLLAAALGLGEEYLGELRGLWVSARPTAPLRHAFQTVNYLFLKEGKLEELRGLYREGRTQIPVQYLLGEEGRPVAFEVYVASERKGIVEGLGEALANPAYPLALGPAYALAWAEGISILEADLRSHWTGIGLGWWEAGKLRLQGTPLGARLYRDRFPLSLGPGRQPMRIGELALEVRGEPLPVQYEGEVLMLGEVAVGVVQV
>NC_017278.1|WP_014514656.1|263780_264740_+|type-I-B-CRISPR-associated-protein-Cas7/Csh2
MVANAEILYLYEAKDTNPNGDPDAENRPRMDYVGQRLLVSDVRLKRYVRDYLLARGEDVWVRSREDGSRTDADGRLEDLKGLYKEETGRDAGAKKKDLDPEFLAWYLRRLRDVRLFGAVLPIKAEGESKGGTGQFVGAVQFDWGYSLHPVEVYTATISSVFAGRTEGGKGEHGTFGKDHRVHYALIAFWGRVSKRRGEAVGLTSEDLEVLEKGLLEGLLEGATTRSKVGQTPRLYLRVDWKEGFRPMGDPRDGLSIRPVEGKAPEGIRSVRDYVLQAHALSESLNSLRESIARVRLWQHPDLQLEGLNLSGLSLEEVNL
>NC_017278.1|WP_155983239.1|261919_263791_+|hypothetical-protein
MIRQLLRLGQSGGEGFRLEDYVQRASGRLYLLDLDPQNRVAGFTPYELDEEKCARFLWVGDPPASNAPRDRATTKDLRYLLGQVPTRMAEHSGLKSLLQGFLWDPGKPGGKARYLLDLRGWRLQGAKDAEAPPFRIQGGRLEMDGTAEGKTAGELAEALAQVLRAAYDIRSPEKGGVLLFSLALSGKPLAEYPEYGDYLRQRLLQEPFAEAQMGICHGCGRKDRVTGNFSAFRLKFYITDKKSFAPGVDEGAFPRAYALCQTCFAALGVGERLAWERLRQRFLERDVLVLPEADFPQESLERLLERLVGQVQGLERLERWKDFLERAAHRQEEVRYLGFSLLFFQRAQAATKAEELVLEVPPSRVEAILKTLQEARERGFPVEGLRDWLFLMPLSRGRKGEMGQMGLALQAVSRIFLQLPLFPKDLLPLWLKTAERVYREDGTLYALTRYRAGQGVIDLVNLGAGWMWVLQRLEVWGGNMEGEVKGALPLTEEEKPLFEAYGFGALRAGLYLLGQAMEAVGQAQARLSEYRKEPLLDSIGWQGMSLVRVRHLVPEVMAKATYYLEGDDRTRVLDLLGRATDLLERSRESLSEREVPYYILMGYAQARSKRLRSGRREEVTHGG
>NC_017278.1|WP_014514654.1|261200_261923_+|CRISPR-associated-endoribonuclease-Cas6
MPSEGGRLSLRFFAEGRLPVTYREGLQAALYQALPLPLGQRLHDGGLLEGHRPLKLFVFSRLQGLLYLREEKAFLAQGELVLHFASALPEVVEGLAKGVWERGGLEVHGLFLRLLGMDLDPLPEGGDLVVEALSPITAYRTEGGRTLYFNPLNREFALLLEANLVRKAQLLGLEAGSLALKPVGFRPQHKRVERYKDTWIEGWMGRYRLEGSPHLIRLALLTGLGAKNSQGFGFVREVKG
>NC_017278.1|WP_014514653.1|258920_261158_-|CRISPR-associated-endonuclease-Cas3''
MLLARTSPDEPLLEHLLGVGALAEGYLAPLGLGEEGRLAGLCHDLGKATPYFQEMLAGQRAKGDPLTWHALLGALYAAWTARQRGMGEKSLLLFLAVLEHHGSLKTPWERIPLGPRQASEKAWKILPKQIRALQESPLFPALVADLGLPPPEAFLGEGAWEEAERLAREADALLDREGRDLGLHYRLALLYSALLDADRRLAGQAPPKGEGIPIPPEAAEAHLARKSRPTPLSPQREALFRGVGEVLEGPLERVFPARLTLTAPTGAGKTLAALRFALALRERVHRERGFRPKVVYALPYIAIADQVEEEARGVLQAAGLKPEEHLLVHHHLALAREEEGSVEEALLLQETWDAEVVVTTFHQLFPTLVGPGSALRPLHALAKGAILILDEVQTLPAELWPFLGELLRQLPGQMTVISMTATQPGLVKGQEVAPHLPSYPRRVRLAWHGARTLEELGQALLQEGPKSRLVVVNTVREAISLYRFLREEGLPHLYLLTSHIIPKHRKARLGEIRAKLQEGQPLTLVATQVVEAGVDLDFQEGYRAFAPMESILQVAGRVNRSALGEGRLWVLDLEGDGGRRVYGTILLDRSRRVLGPRLAEGLWDLEAYALLPQYYRLVEEGISQAKGQDLLAKLARLDYSQLRFTLIEEAPSIPIFIEWDQEATRLLGELEGALTLKDPGERRKRLRPLLARIQGYTVSPLLQRALKNLPPPLLGREEWRHVPREAVADFYDEEMGFLWEMEQFL
>NC_017278.1|WP_014514650.1|257447_258431_-|type-I-B-CRISPR-associated-endonuclease-Cas1
MPKPVYIFSSGRLSRLANTLVLETEDRKRHLPVEQVSELYLFGEVDLNKRFLEFAAQKGILLHFFNRFGYYVGSFYPREHLLSGYLTLRQAQHYLDANRRLNLARRFVEGGLENIRRLLRKEEAKGKRVSDALDTIGEILSQVKGAQHVGELMALEGRARESYYAVWDELLGEEWSLERNRRPPKDPVNALVSFGNTLLYTAILAQIYQTHLDPRIGFLHEANYRRHSLNLDVAEVFKPVLVDRMIFRLIRRGQIKTGHFLREGQGVFLSEAGKRLVVEEWENSLQATYRHLSLKRSVSYRTTLRLELYKLEKHLIEENPYIPYRFR
>NC_017278.1|WP_014514649.1|255827_256067_-|hypothetical-protein
MAFLRVLEDPVLKAKQVKGLQDLVGVLQSRNQPLLIHGLLVPTEKQVEQVQQLGRELLKALQEEGAPSLELEVLPLERL
>NC_017278.1|WP_014514648.1|254006_255779_-|type-III-B-CRISPR-associated-protein-Cas10/Cmr2
MESLLAISLGPVQDFIATARRTRDLYAGSRLLSEAAGKAAEVLAERLGPERLIFPAPKTKEELAKLGQAGIPNVLLARVSEGLDPGALAEVALGAAREYLREKAKELFTREGRRAYVSLEAALDQVGDLLEGYYAHLPLQGDYPQARERVMALLGARKNTRDFRPVSWGSPAYKSSLDGARESVLLLPESRAEALRVRLRLGLREGEYLSGPDLLKRWWEAEGGFVSTIHMAALPFWEGVRKAGKEGLFRKGLEDLAQLAGEEAKGNTRHPALRDTPFWEWDVRLLYESRLEEFPALGEDPRRLEEARGRLRRLLGELGLGSPGSYYALLHADGDRMGEAIDRQKTPEAHRELSRALALDFAAQVRELVQGRGGGLVYSGGDDVLALLPLHRALETAWALARRFQEVMARFGGGEGKPSLSVGLAVVHHLEPLQDALELARKAERLAKEGPEGTPEDEKRNALGVAYSPRSGSELLVRGRWDETPRLTQRLLRYADLLRAGEVPSRAAHELRELLAWRKGLSEEALVAEALRILGRKAMEKKYRQELSDWIQNARDVERLAQELILARPLAEALDQAGIPVESREVWDAH
>NC_017278.1|WP_014514647.1|252907_254017_-|CRISPR-associated-protein-Cmr3
MLIEPRDPLIVRDGRPFTNSPGARAHSLAFPLPQTLAGAYRARRGMEEGLSFPQDADRVREWGLKGPLLAEEAETGWRLLAPRPLDALKLGERVYALRPLEVPEGAGTNLPQGLFPVGLPKTGLKGKPSPLPAFWYWEDWQRWLLEEAPEGFQPKGHGGPTIEVRTHVSLRPEAGTAREGALFQTSGLEFAYRRGEGDGRPHRLALALWPEDGVEVEGIHPLGGERRLAYWRRGGPPLPPMPSGLLEALWEHRAARIVLLTPAFFRKGYLPEKDAFLGAQVVGAAVGRPVVVSGWDLKKGRPKPTRRAVPPGSVYFVRLPGEWSREEVRAFAEKVWLQNLSEEETDRKDGFGLAALGVWSGKPWRWEEV
>NC_017278.1|WP_014514494.1|270255_271476_+|IS256-family-transposase
MFNRGAHLSTRRCPVDQDTLRILLREAVRETVAEVLQTVLELDRTAFLQVHGGRRNGYYPRKLETTFGQVDLKVPRDRESRYYPAFLKPYVRRLVDVGEVAVALYAAGVSQRKAAEILSLLLGHRYSHETLSALTDEVLEAAGAFRTRPLPEEMAFVYLDGLSLKVFREGEGIVRESVYVALGIAPNGERRVLGFWLLPTESALGWEGVLGELWQRGLRRVLLFITDGLPGLPEAIRRVYPQAEWQRCVVHGVRWSLSQVRARDRGLLAEDLRRVYGAESREEALGALEEVKAAWGSRYPGVVGLWVQDSGAFLRFYGYPKVLWPYLRSTNLMERFIREVRRGTKVRDHKFPKEEAVYKLLYLESERQEGRWAERKLKGFSEVKEVLEKMLQERYAPRTQTLTHNS
>NC_017278.1|WP_014514485.1|271714_272806_+|IS4-family-transposase
MEQLTPLINALKRYWKADLRRLTFLAALVMALVTARTTSGPRLALSLGSIASPDPRSAYRRFQRFLAWPGLDGEGYARFIFALLRPQGLLLVMDRTEWELGKSKVNLLMLAFLYQGLAVPLFWSFLPHDGNSSTPERIALMERALAFLRAHFPHLRVEGFLADREFIGEAWFRYLEEKGIPRCIRIKANTRMWRLGSGPRAWELFASLKVGESRVPRRRYWVYGRRMWVVGLRLGVREWLIVATDLDPHRVLEVYGLRWGIERLFGALKGRGFDLEATHVTRGERLSRLLVPLSLAFVWAFRTGLVLHRVRPVRPKKHGRLGQSLFRAGLDLLTLWALALWGAGGGRRGSPLGLCPMEVLTCT
>NC_017278.1|WP_014514661.1|273177_275055_-|DUF262-domain-containing-protein
MPPVHRLLHITLDTTIDMNGADILLKGLNLKTQKKGGRRQMDNERIQTKVFRIRQLLESSVVYQVPRFQRPYSWSRVHWKTFLEDIENTCHLSKDGMPYLHFLGAIITMARPSGVEVVAPYILVDGQQRLITIALLLAAIRNRAAEAGLSSLSHELDKLLRNADEELELKVQPTEFDEAALRGIIRGTPLEELHSPIGNAYSFFTDKLKGRAPEELEVLAKALLDQTEVVRIHLSQGENAYRIFESLNYKGSPLTPADLVRNYLFMRLAAEGKEKEKETYEKVWAPVEEAYKKVFPPSPANSIPHLERMSLGIWHYVRTNGEEIPWDATYPALIDRLNATLKEGKATESFALELKESLADYLFFERPHLETNPKLQRRLEAFRILGFGVAAPLVMALKQRIRKGVLDIEDADQVLAVMEAYYLHRILASVPTNTVGRTVLSVLKNGLLDEPNPAEKVRRFLKGLSGNRRWPDREELEKRNAERSIYVWDGGGRDPRTSHAYYILKRIEQYLWKKLKRKELPNLENLTLEHIMPRTLSEAWKAEIGIDWERTHKSHLNALGNLTLTGYNQEMGNKPFSEKLKVLRESTLSINQEYFRSVSLERWDEQAIRERTKWLLDLVYEIWPA
>NC_017278.1|WP_014514662.1|275017_276238_-|IS256-family-transposase
MFNRGAHLSTRRCPVDQDTLRILLREAVRETVAEVLQTVLELDRTAFLQVHGGRRNGYYPRKLETTFGQVDLKVPRDRESRYYPAFLKPYVRRLVDVGEVAVALYAAGVSQRKAAEILSLLLGHRYSHETLSALTDEVLEAAGAFRTRPLPEEMAFVYLDGLSLKVFREGEGIVRESVYVALGIAPNGERRVLGFWLLPTESALGWEGVLGELWQRGLRRVLLFITDGLPGLPEAIRRVYPQAEWQRCVVHGVRWSLSQVRARDRGLLAEDLRRVYGAESREEALGALEEVKAAWGSRYPGVVGLWVQDSGAFLRFYGYPKVLWPYLRSTNLMERFIREVRRGTKVRDHKFPKEEAVHKLLYLESERQEGRWAERKLKGFSEVKEVLEKMLQERYAPRTQTLTHNS
>NC_017278.1|WP_081477221.1|276398_276731_-|M48-family-metallopeptidase
MRRGVTKRKEATESAWQPLEEAVPVDVFRAEVLAWAERLGVTPREIRIQPMRRKWASCSSRGRLTFDTALLHQPAEFRREVIVHELLHLSVPNHGKLFRALLKAYLVAKE
>NC_017278.1|WP_014514663.1|276723_279642_-|HsdR-family-type-I-site-specific-deoxyribonuclease
MSISSERRTVQNPLLRYATEAGWTYVPPDEALRLRSGEDKPFLHAVLVEQLQRLNPGVVTHATKAEEVVRRLQALRADIEGNREAWEYLKGLKTIFVEADRRERNLRLLDPDRPEDNRFHVTDEFVFRSGARRIRADVVFFINGIPVLVIETKAATRLEGIAEAFDQIRRYHAEAPDLLVHLQLFALTHLVQFFYGATWSLSRKMLFNWREEHGSGDFETLVKSFLAPRRVMRVLTEYILFARKDGELTKVVLRPHQMRATERVLARAHDPQKRRGLIWHTQGSGKTYTMLTIARRLLEDPRFENPTVLLIVDRNELEQQLFQNLEAIGFSRVHLALSKRHLRELLAADTRGIIVSMIHKFDDMPADLCTRHNVFVLVDEAHRSTGGDLGNYLMGALPNATFIGFTGTPIDRTAHGKGTFKTFGTDDPQGYLDKYSIRESIEDGTTVPLHYQLAPNDLIADREAMEREFWAAAELEGVADIEEINRVLDRAVTLTNMLKNPERVAKIAAFVADHFKQYVQPMGYKAFLVAPDREGCVLYKEALDRHLPSEWSAVVISAGHNDPAHLKRYHLSEDAERRLRQAFRKPGENPQIFIVTEKLLTGYDAPILYCMYLDKPMRDHVLLQAIARVNRPYESEQGQRKTTGLIVDFVGIFDNLERALAFDSQDVSGVVQGIDALKARFAQLMDEGRHTYLPIAAGEVGDKAAEALLEHFRDKDRREAFYQFFRELEEVYEILSPDPFLRPHLNDYQRLAEMYRLLRASYEPHIPVDKSFLRKTATIVQQHTHTSLVHEPSATYEIGAAMLMALLNAEQPDTVKVFNLLKELYRLVEAKGHSAPYLLSIGERAEEIRRRFEERQIESQEALRELNELIRQLRAAEEERRQRGDLAARPHAEQAFTVEWWLRLHNIAPERAKEVADTMEAAFAEFPHWMSDRRQEGELRKCLYKALFAISVSDVVAWTNAILDLLRRATDA
>NC_017278.1|WP_081477222.1|279638_280916_-|restriction-endonuclease-subunit-S
MRCTNPDTLPDGYRMTELGPLPEEWQVVRLGEVGKVITGRTPPTSQARFWNGHIPFITPVDLQGKPIRHSERSITEEGLQHAKPLPRGAVLVSCIGYIGKIGIVEAELATTNQQINAVIPFGCDNWFLAYALMHETDVLRSRARMTTVPILHKSNFENIPIPFPPLTEQRAIAHVLRTVQAAKEAGERVVEALRALKKSLMRHLFTYGPVPIDAAEHVPLRDTELGPLPAHWQVVRLGEVAEVKYGRAKPKAEGEIPVIGSGGIYGWADAPLVEFPTLVIGRKGTAGQVWLVEQACWPSDTTYYLIWKKPVDVWFVFGFVSLNPLSGEHARTTLPSLKRHDLENYLIPLPPLPEQREIARMLQAVDQRIQAEEAHVHALEALFRTLLHELMTARRRLPAEFIAKFASHGDQTLRAATPTIEERSL
>NC_017278.1|WP_014514665.1|280912_282481_-|type-I-restriction-modification-system-subunit-M
MDLTTLENWLWEAACAIRGPVDAPKFKDYILPLIFLKRLSDVFEDELRSLAVEFGGIDVAQNLVEQERAHGKVTLVRFYIPENARWETVRRQTSHLGEYLTDAVRALARENPVLAGVIDIVDFNATAAGQRIVPDEYLARLINVLSRYRLGLGDVEPDILGRAYEYLLRKFAEDQGQSAGEFYTPREVGVLMARLLEPEPGMMVYDPTCGSGGLLIKCHLRLLERFGKQENGRLKLPTNIAPLHVFGQEINPATFAIARMNAVIHDIQADIRIGDTMRQPAFKGQGGGLQTFDLVVANPMWNQKFPQELYKNDPYNRFCYGAPPSSSADWGWLQHMLASLNERGRMAVVLDTGAVSRGSGNQGSNRERDIRKAFVEADLIEAVILLPENLFYNTTAPGVIIVVNRRKRYPGQILLINASQLFAKGRPKNYLTEEHIETIASIYHAWGDPAGANRDAPLHAIITREEAARNDYNLSPSRYVSISGSEEVLPLEEALVRLEEAEEERAEAERALQAVLQQLGLR
>NC_017278.1|WP_041433934.1|283204_283957_-|DUF721-domain-containing-protein
MPWRLKEVLPEALKRAGGKERLQRGLVLASWKEVVGRELARLTEAVALEEGVLTVWVADPVTAHQLTYSRLALLRRYEERFPGKVREIRFLVGRLEAPSPEPPPPPKDPEAGRKALALAQLAPSELREAVARAAFALFAHKRGNPCPLCGTPSETHPCPTCRRLLESPLVRKEAERLKRGRPPRLEGEALLVARHLARERLLAEMRELYPQALREAGLRPLLRDLARRFQSLFPEEALPEGVQSLLAKED
>NC_017278.1|WP_014514667.1|283941_284973_-|DNA-replication-and-repair-protein-RecF
MRLRLFRQKGFRNLYLETFHPPPVPFAVVGGNAQGKTSLLLGVHLLLGGEVRASLADLVRFGEREAWLYGEVETELGRYRVEQRLFPEGREIRVNGKAVGLKGLWELPGSVLLLPEDVEVVLGPKEERRGFLDRMIGRFSRRYAALLSAYEKVLRQRNALLKAGGNGLSVWDRELARYGTEIMAFRRRFLRRFLPTFQEVHRSLAPGEVGLALEESAQGDFLEALEQRRPEELLRGQTLLGPHRDDLVFLLAGRPAHRFASRGEAKALALALRLAEHRLLWEHHGEAPLLLVDEWSEELDPGRRKALLTYAQGLPQAILAGLQTPEGMPVCSMAGGVVLCPGG

Crispr_ID: NC_017278_5

• CRISPR_ID: NC_017278_5
• CRISPR_location: 1108124-1109506
• CRISPR_type: Orphan
• Repeat_type: III-A
• Spacer_info: 18 spacers

Consensus repeat of NC_017278_5

Consensus_repeat	Method
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	PILER-CR
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	CRISPRCasFinder
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	CRT

spacers of NC_017278_5

>5.1|1108160|39|NC_017278|PILER-CR,CRISPRCasFinder,CRT
CCCAAAGCATGGCCCAGATGAGGCTCGCAAGGGCGCTGG
>5.2|1108235|38|NC_017278|PILER-CR,CRISPRCasFinder,CRT
GTAAATGTCGCCACCCTGAACATGAATCTCCAGCCTAG
>5.3|1108309|34|NC_017278|PILER-CR,CRISPRCasFinder,CRT
GTAGCCGGGCGCACCTACGAGAGCCGCATCCTAG
>5.4|1108379|43|NC_017278|PILER-CR,CRISPRCasFinder,CRT
GCTAGGGGGCGCTAGCCCGCCAGTGTAGCCACATGGGCACTGG
>5.5|1108458|37|NC_017278|PILER-CR,CRISPRCasFinder,CRT
TGCCCCGGCATGTGGGTGCCCGGTACCTGGCGGCCCA
>5.6|1108531|43|NC_017278|PILER-CR,CRISPRCasFinder,CRT
CCGGTAGGCAGTCCGTTGAGCGCGTGGCCCCAACCCTCGGGAT
>5.7|1108610|40|NC_017278|PILER-CR,CRISPRCasFinder,CRT
TGCAGATAGCCCCCTCACGAATAGTGACCCGCCCCCCACC
>5.8|1108686|40|NC_017278|PILER-CR,CRISPRCasFinder,CRT
TGCAGATAGCCCCCTCACGAATAGTCGACCGCCCCCCACC
>5.9|1108762|40|NC_017278|PILER-CR,CRISPRCasFinder,CRT
CTTGCAACATACCCGCCATCAGGGCTTGGGACGGCGTCAT
>5.10|1108838|37|NC_017278|PILER-CR,CRISPRCasFinder,CRT
CTGTGGAGGCGGCCATTAGGGCCGAACTGGATCACCA
>5.11|1108911|41|NC_017278|PILER-CR,CRISPRCasFinder,CRT
TTCCAACTCCTTCTCCCCAAACATGGCTCACCCCCTACGCC
>5.12|1108988|36|NC_017278|PILER-CR,CRISPRCasFinder,CRT
TGTGTGCGGCAGTCCTTGCACCTGTCGGGGTAGCGC
>5.13|1109060|39|NC_017278|PILER-CR,CRISPRCasFinder,CRT
TTCTCCCAGGCCAGGTTCCACCTGGCCTCCAAGACCTCC
>5.14|1109135|40|NC_017278|PILER-CR,CRISPRCasFinder,CRT
GAATCCTACAGGGACTATTCCAAGAACATCATCAACTAAA
>5.15|1109211|34|NC_017278|PILER-CR,CRISPRCasFinder,CRT
TCTTTCGTAAAATCTTTTGGTGTGGATTTGCGGG
>5.16|1109281|38|NC_017278|PILER-CR,CRISPRCasFinder,CRT
AGCCAAGAACCCTAGCGGCGGTAGCGGCGTTGTTCCCC
>5.17|1109355|40|NC_017278|PILER-CR,CRISPRCasFinder,CRT
GGGTCACCCGTCTGCCCACCCGCCCAGGCCGCAAGGGCCA
>5.18|1109431|40|NC_017278|CRISPRCasFinder,CRT
TCCTCGGGCAGGGACCAGTACCGCCGCATCCGCCGGGAGG

CRISPR arrays and Neighbor proteins around NC_017278_5

CRISPR arrays

The CRISPR arrays of NC_017278_5

>merge|NC_017278|5|1108124-1109506|PILER-CR,CRISPRCasFinder,CRT
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGACCCCAAAGCATGGCCCAGATGAGGCTCGCAAGGGCGCTGGGTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGACGTAAATGTCGCCACCCTGAACATGAATCTCCAGCCTAGGTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGACGTAGCCGGGCGCACCTACGAGAGCCGCATCCTAGGTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGACGCTAGGGGGCGCTAGCCCGCCAGTGTAGCCACATGGGCACTGGGTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGACTGCCCCGGCATGTGGGTGCCCGGTACCTGGCGGCCCAGTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGACCCGGTAGGCAGTCCGTTGAGCGCGTGGCCCCAACCCTCGGGATGTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGACTGCAGATAGCCCCCTCACGAATAGTGACCCGCCCCCCACCGTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGACTGCAGATAGCCCCCTCACGAATAGTCGACCGCCCCCCACCGTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGACCTTGCAACATACCCGCCATCAGGGCTTGGGACGGCGTCATGTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGACCTGTGGAGGCGGCCATTAGGGCCGAACTGGATCACCAGTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGACTTCCAACTCCTTCTCCCCAAACATGGCTCACCCCCTACGCCGTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGACTGTGTGCGGCAGTCCTTGCACCTGTCGGGGTAGCGCGTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGACTTCTCCCAGGCCAGGTTCCACCTGGCCTCCAAGACCTCCGTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGACGAATCCTACAGGGACTATTCCAAGAACATCATCAACTAAAGTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGACTCTTTCGTAAAATCTTTTGGTGTGGATTTGCGGGGTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGACAGCCAAGAACCCTAGCGGCGGTAGCGGCGTTGTTCCCCGTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGACGGGTCACCCGTCTGCCCACCCGCCCAGGCCGCAAGGGCCAGTTGCAAAAGTGGCTTCCCCGTAAGGGGATTGCGACTCCTCGGGCAGGGACCAGTACCGCCGCATCCGCCGGGAGGGTTGCAAAAGTGGCTTCCCCGTAAGGGGATCTTCAC

>NC_017278|5|5|1108124-1109430|PILER-CR
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	CCCAAAGCATGGCCCAGATGAGGCTCGCAAGGGCGCTGG
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	GTAAATGTCGCCACCCTGAACATGAATCTCCAGCCTAG
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	GTAGCCGGGCGCACCTACGAGAGCCGCATCCTAG
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	GCTAGGGGGCGCTAGCCCGCCAGTGTAGCCACATGGGCACTGG
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	TGCCCCGGCATGTGGGTGCCCGGTACCTGGCGGCCCA
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	CCGGTAGGCAGTCCGTTGAGCGCGTGGCCCCAACCCTCGGGAT
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	TGCAGATAGCCCCCTCACGAATAGTGACCCGCCCCCCACC
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	TGCAGATAGCCCCCTCACGAATAGTCGACCGCCCCCCACC
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	CTTGCAACATACCCGCCATCAGGGCTTGGGACGGCGTCAT
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	CTGTGGAGGCGGCCATTAGGGCCGAACTGGATCACCA
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	TTCCAACTCCTTCTCCCCAAACATGGCTCACCCCCTACGCC
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	TGTGTGCGGCAGTCCTTGCACCTGTCGGGGTAGCGC
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	TTCTCCCAGGCCAGGTTCCACCTGGCCTCCAAGACCTCC
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	GAATCCTACAGGGACTATTCCAAGAACATCATCAACTAAA
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	TCTTTCGTAAAATCTTTTGGTGTGGATTTGCGGG
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	AGCCAAGAACCCTAGCGGCGGTAGCGGCGTTGTTCCCC
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	GGGTCACCCGTCTGCCCACCCGCCCAGGCCGCAAGGGCCA
GTTGCAAAAGTGGCTTCCCCGTAAGGGGATTGCGAC

>NC_017278|5|5|1108124-1109506|CRISPRCasFinder
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	CCCAAAGCATGGCCCAGATGAGGCTCGCAAGGGCGCTGG
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	GTAAATGTCGCCACCCTGAACATGAATCTCCAGCCTAG
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	GTAGCCGGGCGCACCTACGAGAGCCGCATCCTAG
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	GCTAGGGGGCGCTAGCCCGCCAGTGTAGCCACATGGGCACTGG
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	TGCCCCGGCATGTGGGTGCCCGGTACCTGGCGGCCCA
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	CCGGTAGGCAGTCCGTTGAGCGCGTGGCCCCAACCCTCGGGAT
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	TGCAGATAGCCCCCTCACGAATAGTGACCCGCCCCCCACC
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	TGCAGATAGCCCCCTCACGAATAGTCGACCGCCCCCCACC
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	CTTGCAACATACCCGCCATCAGGGCTTGGGACGGCGTCAT
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	CTGTGGAGGCGGCCATTAGGGCCGAACTGGATCACCA
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	TTCCAACTCCTTCTCCCCAAACATGGCTCACCCCCTACGCC
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	TGTGTGCGGCAGTCCTTGCACCTGTCGGGGTAGCGC
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	TTCTCCCAGGCCAGGTTCCACCTGGCCTCCAAGACCTCC
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	GAATCCTACAGGGACTATTCCAAGAACATCATCAACTAAA
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	TCTTTCGTAAAATCTTTTGGTGTGGATTTGCGGG
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	AGCCAAGAACCCTAGCGGCGGTAGCGGCGTTGTTCCCC
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	GGGTCACCCGTCTGCCCACCCGCCCAGGCCGCAAGGGCCA
GTTGCAAAAGTGGCTTCCCCGTAAGGGGATTGCGAC	TCCTCGGGCAGGGACCAGTACCGCCGCATCCGCCGGGAGG
GTTGCAAAAGTGGCTTCCCCGTAAGGGGATCTTCAC

>NC_017278|5|5|1108124-1109506|CRT
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	CCCAAAGCATGGCCCAGATGAGGCTCGCAAGGGCGCTGG
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	GTAAATGTCGCCACCCTGAACATGAATCTCCAGCCTAG
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	GTAGCCGGGCGCACCTACGAGAGCCGCATCCTAG
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	GCTAGGGGGCGCTAGCCCGCCAGTGTAGCCACATGGGCACTGG
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	TGCCCCGGCATGTGGGTGCCCGGTACCTGGCGGCCCA
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	CCGGTAGGCAGTCCGTTGAGCGCGTGGCCCCAACCCTCGGGAT
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	TGCAGATAGCCCCCTCACGAATAGTGACCCGCCCCCCACC
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	TGCAGATAGCCCCCTCACGAATAGTCGACCGCCCCCCACC
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	CTTGCAACATACCCGCCATCAGGGCTTGGGACGGCGTCAT
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	CTGTGGAGGCGGCCATTAGGGCCGAACTGGATCACCA
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	TTCCAACTCCTTCTCCCCAAACATGGCTCACCCCCTACGCC
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	TGTGTGCGGCAGTCCTTGCACCTGTCGGGGTAGCGC
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	TTCTCCCAGGCCAGGTTCCACCTGGCCTCCAAGACCTCC
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	GAATCCTACAGGGACTATTCCAAGAACATCATCAACTAAA
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	TCTTTCGTAAAATCTTTTGGTGTGGATTTGCGGG
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	AGCCAAGAACCCTAGCGGCGGTAGCGGCGTTGTTCCCC
GTTGCAAAAGTGGCTTCCCCGCAAGGGGATTGCGAC	GGGTCACCCGTCTGCCCACCCGCCCAGGCCGCAAGGGCCA
GTTGCAAAAGTGGCTTCCCCGTAAGGGGATTGCGAC	TCCTCGGGCAGGGACCAGTACCGCCGCATCCGCCGGGAGG
GTTGCAAAAGTGGCTTCCCCGTAAGGGGATCTTCAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_017278.1|WP_014515535.1|1111136_1111868_-|glycerol-transporter	unknown	unknown	gnl|CDD|240230
NC_017278.1|WP_014515538.1|1115206_1115704_+|phosphohistidine-phosphatase	unknown	unknown	gnl|CDD|224973
NC_017278.1|WP_155983269.1|1106695_1107253_+|methyltransferase	unknown	unknown	gnl|CDD|367574
NC_017278.1|WP_014515543.1|1120681_1121917_-|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|270451
NC_017278.1|WP_014515527.1|1101035_1102340_+|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE	unknown	unknown	gnl|CDD|235392
NC_017278.1|WP_014515532.1|1107253_1107733_+|pantetheine-phosphate-adenylyltransferase	unknown	unknown	gnl|CDD|234674
NC_017278.1|WP_014515536.1|1111851_1113672_-|polyphosphate-kinase	unknown	unknown	gnl|CDD|235469
NC_017278.1|WP_014515526.1|1099761_1101036_+|glutamate-1-semialdehyde-2,1-aminomutase	unknown	unknown	gnl|CDD|234607
NC_017278.1|WP_014515523.1|1096895_1097936_+|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha	unknown	unknown	gnl|CDD|213783
NC_017278.1|WP_041433780.1|1099085_1099721_+|CBS-domain-containing-protein	unknown	unknown	gnl|CDD|341361
NC_017278.1|WP_041433781.1|1103479_1104745_-|O-acetylhomoserine-aminocarboxypropyltransferase/cysteine-synthase	unknown	unknown	gnl|CDD|273555
NC_017278.1|WP_014515539.1|1115700_1116384_+|CHAD-domain-containing-protein	unknown	unknown	gnl|CDD|214880
NC_017278.1|WP_014515530.1|1105236_1106727_+|Na/Pi-cotransporter-family-protein	unknown	unknown	gnl|CDD|224202
NC_017278.1|WP_014515540.1|1116390_1118172_-|amylo-alpha-1,6-glucosidase	unknown	unknown	gnl|CDD|225942
NC_017278.1|WP_014515534.1|1109575_1111168_+|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|143449
NC_017278.1|WP_155983270.1|1118175_1119540_-|ABC-transporter-permease-subunit	unknown	unknown	gnl|CDD|223472
NC_017278.1|WP_014515528.1|1102340_1103483_-|homoserine-O-acetyltransferase	unknown	unknown	gnl|CDD|273596
NC_017278.1|WP_014515524.1|1097929_1098925_+|alpha-ketoacid-dehydrogenase-subunit-beta	unknown	unknown	gnl|CDD|223101
NC_017278.1|WP_014515537.1|1113672_1115199_+|Ppx/GppA-family-phosphatase	unknown	unknown	gnl|CDD|223326
NC_017278.1|WP_014515542.1|1119530_1120634_-|sugar-ABC-transporter-permease	unknown	unknown	gnl|CDD|224096

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_017278.1|WP_014515535.1|1111136_1111868_-|glycerol-transporter	gnl|CDD|240230	PTZ00016, PTZ00016, aquaglyceroporin; Provisional.	3.40226e-43
NC_017278.1|WP_014515538.1|1115206_1115704_+|phosphohistidine-phosphatase	gnl|CDD|224973	COG2062, SixA, Phosphohistidine phosphatase SixA [Signal transduction mechanisms].	1.14563e-19
NC_017278.1|WP_155983269.1|1106695_1107253_+|methyltransferase	gnl|CDD|367574	pfam03602, Cons_hypoth95, Conserved hypothetical protein 95.	7.37983e-38
NC_017278.1|WP_014515543.1|1120681_1121917_-|ABC-transporter-substrate-binding-protein	gnl|CDD|270451	cd14748, PBP2_UgpB, The periplasmic-binding component of ABC transport system specific for sn-glycerol-3-phosphate; possesses type 2 periplasmic binding fold. This group includes the periplasmic component of an ABC transport system specific for sn-glycerol-3-phosphate (G3P) and closely related proteins from archaea and bacteria. Under phophate starvation conditions, Escherichia coli can utilize G3P as phosphate source when exclusively imported by an ATP-binding cassette (ABC) transporter composed of the periplasmic binding protein, UgpB, the transmembrane subunits, UgpA and UgpE, and a homodimer of the nucleotide binding subunit, UgpC. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	6.04049e-78
NC_017278.1|WP_014515527.1|1101035_1102340_+|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE	gnl|CDD|235392	PRK05291, trmE, tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE.	1.00277e-176
NC_017278.1|WP_014515532.1|1107253_1107733_+|pantetheine-phosphate-adenylyltransferase	gnl|CDD|234674	PRK00168, coaD, phosphopantetheine adenylyltransferase; Provisional.	3.19558e-100
NC_017278.1|WP_014515536.1|1111851_1113672_-|polyphosphate-kinase	gnl|CDD|235469	PRK05443, PRK05443, polyphosphate kinase; Provisional.	1.57574e-178
NC_017278.1|WP_014515526.1|1099761_1101036_+|glutamate-1-semialdehyde-2,1-aminomutase	gnl|CDD|234607	PRK00062, PRK00062, glutamate-1-semialdehyde 2,1-aminomutase.	0
NC_017278.1|WP_014515523.1|1096895_1097936_+|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha	gnl|CDD|213783	TIGR03181, PDH_E1_alph_x, pyruvate dehydrogenase E1 component, alpha subunit. Members of this protein family are the alpha subunit of the E1 component of pyruvate dehydrogenase (PDH). This model represents one branch of a larger family that E1-alpha proteins from 2-oxoisovalerate dehydrogenase, acetoin dehydrogenase, another PDH clade, etc. [Energy metabolism, Pyruvate dehydrogenase].	1.26919e-176
NC_017278.1|WP_041433780.1|1099085_1099721_+|CBS-domain-containing-protein	gnl|CDD|341361	cd04584, CBS_pair_AcuB_like, Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the ACT domain. The putative Acetoin Utilization Protein (Acub) from Vibrio Cholerae contains a CBS pair domain. The acetoin utilization protein plays a role in growth and sporulation on acetoin or butanediol for use as a carbon source. Acetoin is an important physiological metabolite excreted by many microorganisms. It is used as an external energy store by a number of fermentive bacteria. Acetoin is produced by the decarboxylation of alpha-acetolactate. Once superior carbon sources are exhausted, and the culture enters stationary phase, acetoin can be utilised in order to maintain the culture density. The conversion of acetoin into acetyl-CoA or 2,3-butanediol is catalysed by the acetoin dehydrogenase complex and acetoin reductase/2,3-butanediol dehydrogenase, respectively. Acetoin utilization proteins, acetylpolyamine amidohydrolases, and histone deacetylases are members of an ancient protein superfamily.This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce acetoin as an external carbon storage compound and then later reuse it as a carbon and energy source during their stationary phase and sporulation. In addition these CBS domains are associated with a downstream ACT (aspartate kinase/chorismate mutase/TyrA) domain, which is linked to a wide range of metabolic enzymes that are regulated by amino acid concentration. Pairs of ACT domains bind specifically to a particular amino acid leading to regulation of the linked enzyme. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).	9.28415e-24
NC_017278.1|WP_041433781.1|1103479_1104745_-|O-acetylhomoserine-aminocarboxypropyltransferase/cysteine-synthase	gnl|CDD|273555	TIGR01326, Includes:_O-acetylhomoserine_sulfhydrylase, OAH/OAS sulfhydrylase. This model describes a distinct clade of the Cys/Met metabolism pyridoxal phosphate-dependent enzyme superfamily. Members include examples of OAH/OAS sulfhydrylase, an enzyme with activity both as O-acetylhomoserine (OAH) sulfhydrylase (EC 2.5.1.49) and O-acetylserine (OAS) sulphydrylase (EC 2.5.1.47). An alternate name for OAH sulfhydrylase is homocysteine synthase. This model is designated subfamily because it may or may not have both activities. [Amino acid biosynthesis, Aspartate family, Amino acid biosynthesis, Serine family].	0
NC_017278.1|WP_014515539.1|1115700_1116384_+|CHAD-domain-containing-protein	gnl|CDD|214880	smart00880, CHAD, The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family. It has conserved histidines that may chelate metals.	6.18193e-12
NC_017278.1|WP_014515530.1|1105236_1106727_+|Na/Pi-cotransporter-family-protein	gnl|CDD|224202	COG1283, NptA, Na+/phosphate symporter [Inorganic ion transport and metabolism].	7.4447e-51
NC_017278.1|WP_014515540.1|1116390_1118172_-|amylo-alpha-1,6-glucosidase	gnl|CDD|225942	COG3408, GDB1, Glycogen debranching enzyme [Carbohydrate transport and metabolism].	7.10189e-77
NC_017278.1|WP_014515534.1|1109575_1111168_+|aldehyde-dehydrogenase-family-protein	gnl|CDD|143449	cd07131, ALDH_AldH-CAJ73105, Uncharacterized Candidatus kuenenia aldehyde dehydrogenase AldH (CAJ73105)-like. Uncharacterized aldehyde dehydrogenase of Candidatus kuenenia AldH (locus CAJ73105) and similar sequences with similarity to alpha-aminoadipic semialdehyde dehydrogenase (AASADH, human ALDH7A1, EC=1.2.1.31), Arabidopsis ALDH7B4, and Streptomyces clavuligerus delta-1-piperideine-6-carboxylate dehydrogenase (P6CDH) are included in this CD.	0
NC_017278.1|WP_155983270.1|1118175_1119540_-|ABC-transporter-permease-subunit	gnl|CDD|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	2.64341e-76
NC_017278.1|WP_014515528.1|1102340_1103483_-|homoserine-O-acetyltransferase	gnl|CDD|273596	TIGR01392, Homoserine_O-acetyltransferase, homoserine O-acetyltransferase. This family describes homoserine-O-acetyltransferase, an enzyme of methionine biosynthesis. This model has been rebuilt to identify sequences more broadly, including a number of sequences suggested to be homoserine O-acetyltransferase based on proximity to other Met biosynthesis genes. [Amino acid biosynthesis, Aspartate family].	1.1611e-163
NC_017278.1|WP_014515524.1|1097929_1098925_+|alpha-ketoacid-dehydrogenase-subunit-beta	gnl|CDD|223101	COG0022, AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion].	2.94556e-168
NC_017278.1|WP_014515537.1|1113672_1115199_+|Ppx/GppA-family-phosphatase	gnl|CDD|223326	COG0248, GppA, Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism].	1.54136e-100
NC_017278.1|WP_014515542.1|1119530_1120634_-|sugar-ABC-transporter-permease	gnl|CDD|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	2.77328e-29

Protein sequences

>NC_017278.1|WP_014515532.1|1107253_1107733_+|pantetheine-phosphate-adenylyltransferase
MHVVYPGSFDPLTNGHLDVIQRASRLFSRVTVAVLENPSKRGQYLFTAQERLGIIREATAHLPNVEAQTFSGLLVDFVRRVGAQAIVKGLRAVSDYEYELQMAHLNRQLLPGLETLFILSATRYSFVSSTMVKEIARYGGDVSKLVPPATLRALKAKFG
>NC_017278.1|WP_155983269.1|1106695_1107253_+|methyltransferase
MGFAAWCWSFKLRGVVRILGGKAKGVPLKVPASARPSPVRLRKALFDYLRLRYPKRGSFLDLYAGSGAVGLEAASEGFTATLVEKDPQAVALLKENARRTGLPVRIVPLPVEVFLPEAQARGERYTVAFMAPPYPMDLVQAFQALLQSGLVEPGGLYILQHPKDLVLPMGERRVYGENALTLVEV
>NC_017278.1|WP_014515530.1|1105236_1106727_+|Na/Pi-cotransporter-family-protein
MEFLAGLGLFLLGLEQIQGGLARLPGRRHLLGRALGRPLGALFFGFLLGLLSGSGSGLSLLALGLLEGRVLTLPLAALLSLAATAGATFWVGVLVLGGPGGAELLLGLGLLLGLLPWGRPLGQVLLGLGLLLLGFGLMGGGAEGVARLLGGLGLPLWGYYLLGVVLALLLGSANGVVALGLALGPALSGAAGVALVLGAGVGTTGSLLLAALGGRREAWRLFLVVGAHRLLLSLPLLALAPWLGGVGTVGLHALSHLLYALLFPLWAGAYGRLAERLFPSPQVAPRYLSKEALDSPRLAQALVQRELARVADAVRDMLAKALRILSQEEGGERELSELEEKVDRLTREVVLYTAELSTKTPDERTVRLFVAASELEHLGDLVRRVVRQAERLWAQGLTFSQEGKEDLLEGLRRVLGRLEGMAAALATGEKALAQEVLAQSKEEEGFLDRLRRAHLARLEGGGQETRATTLAHLDLLITLEELSAGIDRLCRLVLEL
>NC_017278.1|WP_041433781.1|1103479_1104745_-|O-acetylhomoserine-aminocarboxypropyltransferase/cysteine-synthase
MRFETLQLHAGYTPEPTTLSRQVPIYPTTSYVFQSPEHAADLFALRAFGNIYSRIMNPTVEVLEKRLAALEGGKAALAAASGHAAQFLALTTLAQAGDNIVSTPNLYGGTFNQFKVTLKRLGIEVRFTSREERPEEFLALTDQKTRAWWVESIGNPALNIPDLEALAQAAREAGVALIVDNTFGMGGYLLRPLAWGAALVTHSLTKWVGGHGAVIAGAIVDGGNFPWENGRYPLLTEPQPGYHGLRLTEAFGELAFIVKARVDGLRDQGQALGPFEAFLVLLGMETLSLRAERHVENTLHLAHWLREHPQVAWVNYPGLADHPHHARAQKYFRGKPGAVLTFGLKGGYEAAKAFISRLKLISHLANVGDTRTLAIHPASTTHSQLSPEEQALAGVSPEMVRLSVGLEHVEDLKAELQEALG
>NC_017278.1|WP_014515528.1|1102340_1103483_-|homoserine-O-acetyltransferase
MSEIALEAWGEHEALLLKPPRSPLSIPPPRPRTAVLFPRREGFYTELGGYLPEVRLRFETYGRLSRLRDNAVLVFHALTGSAHLAGTYDEATFQSLSPLEQAFGKEGWWDALVGPGRILDPALYYVISANHLGSCYGSTGPLSPDPRTGRPYGRDFPPLTIRDLARAQARLLDHLGVEKAVVIGGSLGGMVALEFALMYPERVRKLVVLAAPARHGPWARAFNHLARQAILQDPEYQKGHPAPRGMALARGIAMMSYRAPQGFEARWGEEPERGETYLDHQGEKFLRRFHAESYLVLSRAMDTHHVGRGRGGLEKALRRLQGLPSLFVGIDSDLLYPAKEVREAARLAGGRYREIRSPHGHDAFLIETDQVEAILDGFLP
>NC_017278.1|WP_014515527.1|1101035_1102340_+|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE
MLQLKDPICAIATPPGKGAIGVVRLSGEGALEVAARVWRGKDPRRLPGGRFTLGVVVDPRTGEALDQALLLVFRAPRSYTGEDACEFHTHGSPAVLRRVLEALVAAGARVAGPGEFTLRAYLHGKLDLAQAEAVLALVEAEGELARRQALRALEGSLSQKIAQLEDRLLSLLAHIQALLDYPEEGVEPLEAERTLRQALEEVEGLLAQAKASRLAQRGARLALVGAPNAGKSSLLNALLGYERALVSPIPGTTRDYLEAPLELFGIPLLAVDTAGVRDTEDPLERAGVERALRIAEEADLVLYVADRSAPRPSPPPLPWGRTLKVASKADLPPAWEDPDFLPVSSRTGEGLGALKEAIREALLGGGGGEYLLTERQAEVLTRVKERLEEALTLPEDLMGLALEEALKALAALRGRGEVAEEVVARVFQNFCVGK
>NC_017278.1|WP_014515526.1|1099761_1101036_+|glutamate-1-semialdehyde-2,1-aminomutase
MERPISQRLFAEAQKHIPGGVSSPVRAFKAVGGTPPFLVRGEGAYVWDADGNRYLDYVMSWGPLILGHAHPEVVRRVQEVAQEGLTFGAPHPLEAQLAQAVKRAYPQVELVRFVNSGTEATMSAIRLARGYTGRKYLVKFRGNYHGHADGLLVEAGSGALTLGVPSSAGVPEEYARLTLVLEYNDPEALRALLRERGEEIAAILFEPVVGNAGVLVPTPDFLQALHEARAYGVLLIADEVMTGFRLAFGGATERLGLKPDLITLGKILGGGLPAAAYAGRREIMEKVAPLGPVYQAGTLSGNPLAMAAGLATLEILERNPGYYAYLEGLGAALEAGLRQLLSRKGIPHAVNRVGSMLTVFFAEGPVVTFQDAKRTDLGLFRRFFHGLLDRGVYWPPSNFEAAFLSVAHREEDVAKTLEALDQAL
>NC_017278.1|WP_041433780.1|1099085_1099721_+|CBS-domain-containing-protein
MSWGPVGAPLLKDLMRTELVVAEPRMSLEEAHRLMVQTGVRYLPVVEGRRYLGLLGERHLRLPLAPWAPKHLQADLKAPVGRFLKPFPEAHPDEPPEEAAFRMEAARVGAMPVVEEGRLLGLVTAYDLLRGLLALFRPQVPASRLEVLVPDLERLEAVLQALRATRTPLVGLHVYPEAGGLGFRLLLQVGVLDPRPLRERLWALGLYPFSP
>NC_017278.1|WP_014515524.1|1097929_1098925_+|alpha-ketoacid-dehydrogenase-subunit-beta
MVAEKARVLNMVQAIQEALDLALARDERVLVFGEDVGRLGGVFRVTEGLQAKYGEARVFDTPLAESGILGLAMGLAMGGMRPVAEIQFAGFLYPALDQILSHLGRWRHRSRGRVGLPVVVRAPYGGGVHTPEQHADSPEALLAHTPGVKVVIPASPERAKGLLLAAIEDEDPVFFLEAIKLYRGARAEVPEGYYTLPLGKARILRQGKAATLIGYGGMVEVMLEAAEVARKEGVEVTVLDLETLVPLDEDTLLEAVRETGRAIVVYEAMRTGGFGAEIAARIAEGAIDYLQAPVLRVAGYDAPYPPFSAIEHLYRPNARRVLAALRRALTH
>NC_017278.1|WP_014515523.1|1096895_1097936_+|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha
MKLKAVAYLSNGEFPVAEGEALALYRAMRRARFFDEKAMTLQRQGRLGVYAPFMGQEAAQVGLALALGEGDWVVPSYRESALLLARGLPIHTLLLYWRAHPAGWGFPEGVRAVNPYIPIATQIPQAVGLALAGRYRGEDWVVATSIGDGGTSEGDFHEGLNFAAVFSAPVVFLVQNNGYAISVPRSRQMRVDYIARRAEGYGMPGVVVDGNDALAVYLEAKRAVERARRGEGPTLLEALTYRLAPHTTSDDPSRYRTREEEEAWRAKDPILRLRKALEERGLWDEGQEAALLEELEAEFARELSLADAAPEPRPEEIVEHVYAAMGPDQRRAWEALRRGQHVEEVW
>NC_017278.1|WP_014515534.1|1109575_1111168_+|aldehyde-dehydrogenase-family-protein
MKAFASKYGNTLEFGHLIGGEEVWEGEALERHNPSDREDLVARFPEGTKDTLRRAALKAREAFAEWSRTPAPVRGQVLFNLAKILEREKPTLVRLMVREVGKTFKEAGGDVQEAIDTALFFASEGRRLYGQTVPSEMRDKELFTFRRPLGVVGMITAGNFPIAVPSWKLIPAVLTGNAVVWKPSDDSPTLSYVFVKLFEEAGLPPGVINVVFGGGKGSTGQWLVELMDEGLLNKFAFTGSTQVGRWIGEVAGRNLIRPTLELGGKNPLVVMRDADLDLAVEGAWWSAFATGGQRCTSAGNILVDAPIYEEFKRRFLERTEATVVGNPLLHPEVTYGPFLNERLFRRWQEHYAWGQEDGATLLFGRGRIGRDNPYPRFLGDPEAGLYGWPTVWEAAPGMRQFQEEIFGPTINLVKVDGIEEAIAVANATPYGLSSAIYTHHRHWAYLFKVGIRAGMTSINNATVGAEAHLPFGGVKASGNGARESGIWVIEEYTYWHAVNEEYSGRLQLAQMDTGYVSPKPPTPWGEVLGL
>NC_017278.1|WP_014515535.1|1111136_1111868_-|glycerol-transporter
MPSAPRAFWGEVWGTFLLVLLTVGSAANAVLQPRLFPGAYGYDALALGSGLAVLVGVLVSRPLSGAHLNPAVTLALAALRLFPWSRVPLYLLAQFLGGFLGALGAYLAYGEGLWAQGMPNVFSTGPGFLRTPPEATYGWAGPAVAEFLGTMALMGVILAAREERLLPLWLALTVAAVGYGLGGPGGFALNPARDLSPRLLAALLGAEGALNAYALVPALLPVAGALGAAFLYRLTTPAPPPRE
>NC_017278.1|WP_014515536.1|1111851_1113672_-|polyphosphate-kinase
MRLLPEASWLQFNRRVLRQSERPDFPLLERLRFLAIWNRNLDEFFAARIAKPFLEARGSPAHLALLEEALAQARLAQARYQALLAEARPRLRVLEVRELDELDWIYFRVFLAEVVAPKTDLIPWEAAADLSHGALYFASESHLVRLPQDLPRLLPVPGREGTYVRLGALMRARSDLFLPQEGPLYEFRVLRLLESERARADWDELAQALEGRQEGAPTLLVAEEGFPEAWLEGLRQALELRPEEVFRLPPPLNLALVETLVAEGPPEWRFPPLRPERPRAFLKNPLARLQEKDLLLYHPFEDYKAVERFAQEALRPEVEEVWATLYRIGETNPLAEALLQAAQKGKRVHVLLEARARFDELLNLFWYLRFLRAGVEVLPLPERKVHAKALLLLTREGGYVHLGTGNYNPQNGRAYTDFSLFTAQPEVVAEVRAFFRAIREERPPQLSLLKTGEAIRHCLVEAILAEAHPKGRVILKFNHLTDPQVLEALVQAAERGARVDLLVRSTLTLLHPRLRARSLVGRFLEHARVAAFRAGGRWRVYLTSADAMPRNFQNRFELLFPVEDRKAKLKVLKVLKRQVRDERNAFLLTPQGEEVLWGGRHDAQRP
>NC_017278.1|WP_014515537.1|1113672_1115199_+|Ppx/GppA-family-phosphatase
MLQIRTQQGQEGVKERSLAVLDLGSGTFRLVVYRYRPGLSYVLADELREAVALGEGLAQGRIGLAALERGRKALRAFADFLQASPVDEVVSLATSAVRDAENGAQILAEARALGLDPRVLPGEEEARLGVLAVANALPLAEAWVVDQGGGSAQVSRMEGRAFRWGRALPLGALRLTEAFLASDPPTREEVKALEREVARHLKALPLEGGLPLVGLGGNIRAMARLHQKRRAYPLDLLHGAYLSREAVEELYQDLLRLPWRARAGLGLQPDRARTLPASLAFFRTLMKRLRAPGLWVSGVGIREGVLFAHLLPPPHLLPDPRAFAVENLFQRYPFALAHRDRVKALARELFLGLQPLHRYGEEEARLLEEAAHLHDIGMHLGYHDHHKHGAYLVLAEPLFGFSHREQALLALLVRYHRRGEPALGGLRPLFGRGDGRRLLRLSAILRLAEMLERSRAGRVRGVRVELGERIRLRLLAPEDPWVERVEAEKQGGLFLQAFGLPLEVVWGA
>NC_017278.1|WP_014515538.1|1115206_1115704_+|phosphohistidine-phosphatase
MELFLVRHAIALPAEGEGEEADDARPLSPKGVKRFRKVVRGLRALGVELDYLLTSPKRRALETAEMLSDLLQGESRVTPHLALPPSPALLEEIPKEGRVALVGHEPYLSGLLAWLLLGDFLGESARGDLGERFPLKKGGVAWLEGEVRPGGMCLRALFPPKVFRL
>NC_017278.1|WP_014515539.1|1115700_1116384_+|CHAD-domain-containing-protein
MRTPREWVDHLEAHLPLALSGADPEGVHQVRVAGRRLRAYLNLLGWRVLQDDLRRLVRGAGRVRDLEVALGHPLPPGFRAHLEEEVRQAREALPPLLASPWTAALLRALRVLPPLGEEAWGRLRRQERRAEARLKALQAEPSLEALHAYRRALRRVRYAKEFLGLSAKREKALQEALGGLQDLEVLLGLLEGYLAQAPDPEGEALRAELLARRQEALAGVLEALREA
>NC_017278.1|WP_014515540.1|1116390_1118172_-|amylo-alpha-1,6-glucosidase
MIPLKEDDTYLVLNARGFAEEGAEGFYRHDTRFLARYRLLLPEGLALLQSRSPRPDRLVQDWARFQGPDGEIYLRREVRVGRGRVWDRLTFRNLSHQAQSLRVGLEAVGSFVDLFQARGWHPTAPSPRGLHYRAEDGVEQRVDISPTPPPEGFSLPLPPREEASLTLEITLESPLGNPGDLPEYETFLEAFPQATGPWEAPLRQALLDLRALLLSTPEGPIPAAGIPWYVAPFGRDSLLTAFMLLPWGKAVAQGVLRYLAERQGKVVDPRREEEPGKILHEVRLGELSRTGKVPFARYFGTVDATPLFLVLLGRYLELTGDLALVRELRPAWESALAWLSRADLDGDGLLEFQPSGGGLAVHSWKDSHDSMSHQDGRLAEPPLAVSEVQGYAYAAHRAAAGFYRALGEEAQAQTHEGRAQTLFQLIQEHFWLPDLNTYALALDRHKKPLRVKASDAGHLLWAGAVLQERAKTLVNTLFSEELWSGWGLRTLGSREVRYNPLSYHNGSVWPHDTALFAGGLFRYGFKEEGERVVQALLDLAKSQPDLRLPELVGGFPREKDQPPVPYPVACRPQAWDAGTVVYLYALSQGLRDW
>NC_017278.1|WP_155983270.1|1118175_1119540_-|ABC-transporter-permease-subunit
MVLMEAVRRRWARVAWAYGLLLAFGVFFVGPFLMGFLASLKTDPLEWPFTLRFAQVSPKNWAAAWRLGREGSGDPWLGGMRPGRAVSLEVAYFSPEVKEPHLLAQIPRRKPGAGMGAVFETPYAADHVRLEGPTLVERRPAQLGEVRGEVFRYRLRLVYPGEGPFLERVPLDLEAPRGVVLVGATLDPIRFERRGRVASWDNVVPGLAGYLFHNYVRAFRETRSLETGESLFLRWTLNSFFLSFIKVLTTLVFASMAGYALARMRFPGRQALFLFMLFTMMVPGQVTFISNYLVLRDGIFGLSRLFGVDTLLNTYTGLVLSGLVGASAVFIMKQFFESIPREVEEAALIDGATPLQTLFRIVLPMSTPALGALAILTFQGTWNEFFWPFVVLTSPREIYTLPIGLLSFRNAYGQVGDWGLILAGGFFSMIPVLILFAVFQRYFVEGVSVGAVKE
>NC_017278.1|WP_014515542.1|1119530_1120634_-|sugar-ABC-transporter-permease
MRLKARTLEGLYAFLLLFPFLFSLGVFFLYAFLRAVFFSFTEYNLFDPPRWVGLANYLRLLQEPLFLTALKHTLAYSLVVTSLQTFFALLLAVALNQPLKGITFFRTVYYLPSVISTAAASLLLLWLFQRTGLVNQGLSLLLSHLGQLGGFAGLFLAAQALQVAWERRKGAAVSFWDPALAALSLLVAFLGAWALGASGLLPPREVRVEIPWLPTQASFLGIPYPLWAIILMNTYTTIPTFMVLFLAGLKGIPKTLYEAAALDGATPWTMFTRITVPLLRPVLFLVITMGLIGTLQLFDQVLFVGGSGGAPLESTITLAYYVYGNVFPSGAAPRVGLASAAALVLAGLTLLIVLLQRRFGVGERGWS
>NC_017278.1|WP_014515543.1|1120681_1121917_-|ABC-transporter-substrate-binding-protein
MKARFLMAILVLLGLALAQTQVRISGWGGTDIAIVNGLLKEVVQPKLDREGIRVVYEPIEGDYTQWLFNALSAGTAPDLFYVDIFWSESLFATGRVEPLDAYFSRQEVAEFLPNLIQAFTYKGKLYGIPKDFNTLALQFNRDLFDEAGVRYPHQQDTWETFEAKLKEVQSKLKDVAGLCVVADFARFGAFAFATGWKPFDEKGRTVLDQNFRRAFEWYTGLPKRGAARFAQDLGEGWTGGCFGGEKAATALEGAWIAGFLRDKAPNMRYGTTFLPLDPVSKKRGNFVYTVSWSMNAASKNKQAAAKVLKALTSPEAQQWVLERGLAIPSRRALANNPYFQRPGKEPELNRIVFQGSTAQGGNVYPFKFQAFGGDWMRPINDALLAVMTGQKTVDQALRDAQAALDRLTGGR

Crispr_ID: NC_017278_6

• CRISPR_ID: NC_017278_6
• CRISPR_location: 1331327-1332116
• CRISPR_type: TypeIII
• Repeat_type: III-A
• Spacer_info: 10 spacers
• Cas_protein_info: cas2,csx1,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,cas1

Consensus repeat of NC_017278_6

Consensus_repeat	Method
GCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	CRT
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	CRISPRCasFinder
GTTGCAAAAGTGGCTTCCCCGTAAGGGGATTGCGAC	PILER-CR

spacers of NC_017278_6

>6.1|1331360|41|NC_017278|CRT
GGCAAAACCAAGACTAAGTATATCAAAAACCCAGCAGGATT
>6.2|1331434|46|NC_017278|CRT
TGGCTACTAGGAAGCGGGGGCAGGCTCAATCTGTTCCGCCTGAGTC
>6.3|1331513|39|NC_017278|CRT
CGTTGTAACTCTGCAGCTTAGAAGTTTACGGGACGAGTC
>6.4|1331585|42|NC_017278|CRT
GTAGGCGCTAGCCCGCTACGCGCCCCCGGGGATATCCCCGTC
>6.5|1331660|43|NC_017278|CRT
TCATAGCCTTAGCTAGGTACGAGTTCATCAGGTTGCGCCTGTC
>6.6|1331736|45|NC_017278|CRT
AAATTGTATATGTCATGATTTCCATGCCGGGGTATGATATATGTC
>6.7|1331814|44|NC_017278|CRT
TACGAGACCCGCCAGGTCCCCAAGGTGGCCGGGTTCAGGTGGTT
>6.8|1331891|43|NC_017278|CRT
CCATGCGTGAAAAAATCCAGTTTGGGGTCAACGCCCAGCCGTC
>6.9|1331967|43|NC_017278|CRT
ACGCCCTCTTCAGTGAGGAGGGGGAGCCCCTCGAGGAGTTGTC
>6.10|1332043|41|NC_017278|CRT
TTTACGAAAGGGTCCTCCGGGCTGTTTCGGAGGAGCTTGTC
>6.11|1331434|43|NC_017278|CRISPRCasFinder
TGGCTACTAGGAAGCGGGGGCAGGCTCAATCTGTTCCGCCTGA
>6.12|1331513|36|NC_017278|CRISPRCasFinder,PILER-CR
CGTTGTAACTCTGCAGCTTAGAAGTTTACGGGACGA
>6.13|1331585|39|NC_017278|CRISPRCasFinder,PILER-CR
GTAGGCGCTAGCCCGCTACGCGCCCCCGGGGATATCCCC
>6.14|1331660|40|NC_017278|CRISPRCasFinder,PILER-CR
TCATAGCCTTAGCTAGGTACGAGTTCATCAGGTTGCGCCT
>6.15|1331736|42|NC_017278|CRISPRCasFinder,PILER-CR
AAATTGTATATGTCATGATTTCCATGCCGGGGTATGATATAT
>6.16|1331814|41|NC_017278|CRISPRCasFinder,PILER-CR
TACGAGACCCGCCAGGTCCCCAAGGTGGCCGGGTTCAGGTG
>6.17|1331891|40|NC_017278|CRISPRCasFinder,PILER-CR
CCATGCGTGAAAAAATCCAGTTTGGGGTCAACGCCCAGCC
>6.18|1331967|40|NC_017278|CRISPRCasFinder,PILER-CR
ACGCCCTCTTCAGTGAGGAGGGGGAGCCCCTCGAGGAGTT
>6.19|1332043|38|NC_017278|CRISPRCasFinder,PILER-CR
TTTACGAAAGGGTCCTCCGGGCTGTTTCGGAGGAGCTT

CRISPR arrays and Neighbor proteins around NC_017278_6

CRISPR arrays

The CRISPR arrays of NC_017278_6

>merge|NC_017278|6|1331327-1332116|CRT,CRISPRCasFinder,PILER-CR
GAGTTTCTTTTACAGGGAAGCCACTTGTGTCGCGGCAAAACCAAGACTAAGTATATCAAAAACCCAGCAGGATTGCAATCCCCTTACGGGGAAGCCACTTTTGCAACTGGCTACTAGGAAGCGGGGGCAGGCTCAATCTGTTCCGCCTGAGTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAACCGTTGTAACTCTGCAGCTTAGAAGTTTACGGGACGAGTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAACGTAGGCGCTAGCCCGCTACGCGCCCCCGGGGATATCCCCGTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAACTCATAGCCTTAGCTAGGTACGAGTTCATCAGGTTGCGCCTGTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAACAAATTGTATATGTCATGATTTCCATGCCGGGGTATGATATATGTCGCAATCCCCTTACGAGGAAGCCACTTTTGCAACTACGAGACCCGCCAGGTCCCCAAGGTGGCCGGGTTCAGGTGGTTGCAATCCCCTTACGGGGAAGCCACTTTTGCAACCCATGCGTGAAAAAATCCAGTTTGGGGTCAACGCCCAGCCGTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAACACGCCCTCTTCAGTGAGGAGGGGGAGCCCCTCGAGGAGTTGTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAACTTTACGAAAGGGTCCTCCGGGCTGTTTCGGAGGAGCTTGTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC

>NC_017278|6|6|1331327-1332116|CRT
GAGTTTCTTTTACAGGGAAGCCACTTGTGTCGC	GGCAAAACCAAGACTAAGTATATCAAAAACCCAGCAGGATT
GCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	TGGCTACTAGGAAGCGGGGGCAGGCTCAATCTGTTCCGCCTGAGTC
GCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	CGTTGTAACTCTGCAGCTTAGAAGTTTACGGGACGAGTC
GCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	GTAGGCGCTAGCCCGCTACGCGCCCCCGGGGATATCCCCGTC
GCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	TCATAGCCTTAGCTAGGTACGAGTTCATCAGGTTGCGCCTGTC
GCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	AAATTGTATATGTCATGATTTCCATGCCGGGGTATGATATATGTC
GCAATCCCCTTACGAGGAAGCCACTTTTGCAAC	TACGAGACCCGCCAGGTCCCCAAGGTGGCCGGGTTCAGGTGGTT
GCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	CCATGCGTGAAAAAATCCAGTTTGGGGTCAACGCCCAGCCGTC
GCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	ACGCCCTCTTCAGTGAGGAGGGGGAGCCCCTCGAGGAGTTGTC
GCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	TTTACGAAAGGGTCCTCCGGGCTGTTTCGGAGGAGCTTGTC
GCAATCCCCTTACGGGGAAGCCACTTTTGCAAC

>NC_017278|6|6|1331398-1332116|CRISPRCasFinder
ATTGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	TGGCTACTAGGAAGCGGGGGCAGGCTCAATCTGTTCCGCCTGA
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	CGTTGTAACTCTGCAGCTTAGAAGTTTACGGGACGA
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	GTAGGCGCTAGCCCGCTACGCGCCCCCGGGGATATCCCC
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	TCATAGCCTTAGCTAGGTACGAGTTCATCAGGTTGCGCCT
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	AAATTGTATATGTCATGATTTCCATGCCGGGGTATGATATAT
GTCGCAATCCCCTTACGAGGAAGCCACTTTTGCAAC	TACGAGACCCGCCAGGTCCCCAAGGTGGCCGGGTTCAGGTG
GTTGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	CCATGCGTGAAAAAATCCAGTTTGGGGTCAACGCCCAGCC
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	ACGCCCTCTTCAGTGAGGAGGGGGAGCCCCTCGAGGAGTT
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	TTTACGAAAGGGTCCTCCGGGCTGTTTCGGAGGAGCTT
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC

>NC_017278|6|6|1331477-1332116|PILER-CR
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	CGTTGTAACTCTGCAGCTTAGAAGTTTACGGGACGA
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	GTAGGCGCTAGCCCGCTACGCGCCCCCGGGGATATCCCC
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	TCATAGCCTTAGCTAGGTACGAGTTCATCAGGTTGCGCCT
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	AAATTGTATATGTCATGATTTCCATGCCGGGGTATGATATAT
GTCGCAATCCCCTTACGAGGAAGCCACTTTTGCAAC	TACGAGACCCGCCAGGTCCCCAAGGTGGCCGGGTTCAGGTG
GTTGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	CCATGCGTGAAAAAATCCAGTTTGGGGTCAACGCCCAGCC
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	ACGCCCTCTTCAGTGAGGAGGGGGAGCCCCTCGAGGAGTT
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	TTTACGAAAGGGTCCTCCGGGCTGTTTCGGAGGAGCTT
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_017278.1|WP_014515730.1|1326215_1326620_+|type-III-A-CRISPR-associated-protein-Csm2	csm2gr11	cd09647_csm2gr11_CAS-III-A	gnl|CDD|187778
NC_017278.1|WP_014515738.1|1333421_1334627_-|TIGR02710-family-CRISPR-associated-protein	csx1	cd09702_csx1_CAS-III	gnl|CDD|274263
NC_017278.1|WP_014515734.1|1329354_1330503_+|TIGR02221-family-CRISPR-associated-protein	csx1	pfam09455_csx1_CAS-III	gnl|CDD|378186
NC_017278.1|WP_014515737.1|1332474_1333422_-|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|187766
NC_017278.1|WP_041433807.1|1322993_1323707_-|CRISPR-associated-endoribonuclease-Cas6	cas6	pfam10040_cas6_CAS-III:CAS-IV	gnl|CDD|273848
NC_017278.1|WP_014515732.1|1327361_1328228_+|hypothetical-protein	csm4gr5	mkCas0089_csm4gr5_CAS-III-A:CAS-III-D	gnl|CDD|273866
NC_017278.1|WP_014515733.1|1328224_1329352_+|type-III-A-CRISPR-associated-RAMP-protein-Csm5	csm5gr7	cd09662_csm5gr7_CAS-III-A	gnl|CDD|187793
NC_017278.1|WP_014515742.1|1338076_1339381_-|phosphomethylpyrimidine-synthase-ThiC	unknown	unknown	gnl|CDD|237359
NC_017278.1|WP_014515729.1|1323785_1326215_+|type-III-A-CRISPR-associated-protein-Cas10/Csm1	cas10	cd09680_cas10_CAS-III	gnl|CDD|187811
NC_017278.1|WP_014515743.1|1339377_1340307_-|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|274092
NC_017278.1|WP_155983273.1|1334688_1335696_+|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl|CDD|223157
NC_017278.1|WP_014515745.1|1341086_1341281_-|sulfur-carrier-protein-ThiS	unknown	unknown	gnl|CDD|340451
NC_017278.1|WP_014515727.1|1321125_1322982_+|amino-acid-transporter	unknown	unknown	gnl|CDD|372624
NC_017278.1|WP_014515746.1|1341267_1341888_-|thiamine-phosphate-synthase	unknown	unknown	gnl|CDD|234590
NC_017278.1|WP_041433808.1|1326631_1327372_+|type-III-A-CRISPR-associated-RAMP-protein-Csm3	csm3gr7	cd09684_csm3gr7_CAS-III-A:CAS-III-D	gnl|CDD|187815
NC_017278.1|WP_041433806.1|1319805_1321062_+|nitrate/sulfonate/bicarbonate-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224041
NC_017278.1|WP_014515735.1|1330499_1330769_-|CRISPR-associated-endonuclease-Cas2	cas2	mkCas0081_cas2_CAS-I:CAS-II:CAS-III	gnl|CDD|187856
NC_017278.1|WP_014515741.1|1337283_1338066_-|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	unknown	unknown	gnl|CDD|180561
NC_017278.1|WP_041433991.1|1335730_1337236_-|alkaline-phosphatase	unknown	unknown	gnl|CDD|224699
NC_017278.1|WP_014515744.1|1340303_1341086_-|thiazole-synthase	unknown	unknown	gnl|CDD|234687

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_017278.1|WP_014515733.1|1328224_1329352_+|type-III-A-CRISPR-associated-RAMP-protein-Csm5	csm5gr7	cd09662_csm5gr7_CAS-III-A	3.4e-19	64.0	0.0
NC_017278.1|WP_041433808.1|1326631_1327372_+|type-III-A-CRISPR-associated-RAMP-protein-Csm3	csm3gr7	cd09684_csm3gr7_CAS-III-A:CAS-III-D	3e-78	257.2	0.0
NC_017278.1|WP_014515730.1|1326215_1326620_+|type-III-A-CRISPR-associated-protein-Csm2	csm2gr11	cd09647_csm2gr11_CAS-III-A	6.4e-25	82.7	1.0
NC_017278.1|WP_041433807.1|1322993_1323707_-|CRISPR-associated-endoribonuclease-Cas6	cas6	pfam10040_cas6_CAS-III:CAS-IV	2e-24	81.2	0.8
NC_017278.1|WP_014515738.1|1333421_1334627_-|TIGR02710-family-CRISPR-associated-protein	csx1	cd09702_csx1_CAS-III	2.7e-131	432.5	1.9
NC_017278.1|WP_014515734.1|1329354_1330503_+|TIGR02221-family-CRISPR-associated-protein	csx1	pfam09455_csx1_CAS-III	2.6e-60	199.3	0.0
NC_017278.1|WP_014515735.1|1330499_1330769_-|CRISPR-associated-endonuclease-Cas2	cas2	mkCas0081_cas2_CAS-I:CAS-II:CAS-III	7.5e-52	168.5	0.8
NC_017278.1|WP_014515737.1|1332474_1333422_-|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	1.4e-76	252.3	0.0
NC_017278.1|WP_014515729.1|1323785_1326215_+|type-III-A-CRISPR-associated-protein-Cas10/Csm1	cas10	cd09680_cas10_CAS-III	9.7e-148	488.2	0.0
NC_017278.1|WP_014515732.1|1327361_1328228_+|hypothetical-protein	csm4gr5	mkCas0089_csm4gr5_CAS-III-A:CAS-III-D	7.6e-53	174.6	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_017278.1|WP_014515730.1|1326215_1326620_+|type-III-A-CRISPR-associated-protein-Csm2	gnl|CDD|187778	cd09647, Csm2_III-A, CRISPR/Cas system-associated protein Csm2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Small alpha-helical protein; signature gene for subtype III-A.	3.09158e-17
NC_017278.1|WP_014515738.1|1333421_1334627_-|TIGR02710-family-CRISPR-associated-protein	gnl|CDD|274263	TIGR02710, conserved_hypothetical_protein, CRISPR-associated protein, TIGR02710 family. Members of this family are found, exclusively in the vicinity of CRISPR repeats and other CRISPR-associated (cas) genes, in Methanothermobacter thermautotrophicus (Archaea), Thermus thermophilus (Deinococcus-Thermus), Chloroflexus aurantiacus (Chloroflexi), and Thermomicrobium roseum (Thermomicrobia).	3.7512e-131
NC_017278.1|WP_014515734.1|1329354_1330503_+|TIGR02221-family-CRISPR-associated-protein	gnl|CDD|378186	pfam09455, Cas_DxTHG, CRISPR-associated (Cas) DxTHG family. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. The family describes Cas proteins of about 400 residues that include the motif [VIL]-D-x-[ST]-H-[GS]. The CRISPR and associated proteins are thought to be involved in the evolution of host resistance. The exact molecular function of this family is currently unknown.	1.11177e-66
NC_017278.1|WP_014515737.1|1332474_1333422_-|CRISPR-associated-endonuclease-Cas1	gnl|CDD|187766	cd09634, Cas1_I-II-III, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	2.85368e-94
NC_017278.1|WP_041433807.1|1322993_1323707_-|CRISPR-associated-endoribonuclease-Cas6	gnl|CDD|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	3.05087e-16
NC_017278.1|WP_014515732.1|1327361_1328228_+|hypothetical-protein	gnl|CDD|273866	TIGR01903, Hypothetical_protein., CRISPR type III-A/MTUBE-associated RAMP protein Csm4. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. Members of this cas gene family are found in the mtube subtype of CRISPR/cas locus and designated Csm4, for CRISPR/cas Subtype Mtube, protein 4.	5.62757e-08
NC_017278.1|WP_014515733.1|1328224_1329352_+|type-III-A-CRISPR-associated-RAMP-protein-Csm5	gnl|CDD|187793	cd09662, Csm5_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein.	6.95373e-13
NC_017278.1|WP_014515742.1|1338076_1339381_-|phosphomethylpyrimidine-synthase-ThiC	gnl|CDD|237359	PRK13352, PRK13352, phosphomethylpyrimidine synthase ThiC.	0
NC_017278.1|WP_014515729.1|1323785_1326215_+|type-III-A-CRISPR-associated-protein-Cas10/Csm1	gnl|CDD|187811	cd09680, Cas10_III, CRISPR/Cas system-associated protein Cas10. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Multidomain protein with permuted HD nuclease domain, palm domain and Zn-ribbon; signature gene for type III; also known as Csm1 family.	0
NC_017278.1|WP_014515743.1|1339377_1340307_-|FAD-dependent-oxidoreductase	gnl|CDD|274092	TIGR02352, Glycine_oxidase, glycine oxidase ThiO. This family consists of the homotetrameric, FAD-dependent glycine oxidase ThiO, from species such as Bacillus subtilis that use glycine in thiamine biosynthesis. In general, members of this family will not be found in species such as E. coli that instead use tyrosine and the ThiH protein. [Biosynthesis of cofactors, prosthetic groups, and carriers, Thiamine].	3.20569e-29
NC_017278.1|WP_155983273.1|1334688_1335696_+|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	gnl|CDD|223157	COG0079, HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism].	1.61196e-59
NC_017278.1|WP_014515745.1|1341086_1341281_-|sulfur-carrier-protein-ThiS	gnl|CDD|340451	cd00565, Ubl_ThiS, ubiquitin-like (Ubl) domain found in sulfur carrier protein ThiS. ThiS, also termed Thiamine biosynthesis protein (ThiaminS), is a sulfur carrier protein involved in thiamin biosynthesis in prokaryotes. It has the beta-grasp ubiquitin-like (Ubl) fold with low sequence similarity to ubiquitin (Ub), and is activated in an ATP-dependent manner by sulfurtransferases, similar to the activation mechanism of Ub-activating enzyme E1. ThiS has common evolutionary origin with Ub-related protein modifiers in eukaryotes, a beta-grasp fold as Ub, and is closely related to proteins MoaD and Urm1.	5.49569e-13
NC_017278.1|WP_014515727.1|1321125_1322982_+|amino-acid-transporter	gnl|CDD|372624	pfam13520, AA_permease_2, Amino acid permease.	8.13601e-09
NC_017278.1|WP_014515746.1|1341267_1341888_-|thiamine-phosphate-synthase	gnl|CDD|234590	PRK00043, thiE, thiamine phosphate synthase.	3.42132e-77
NC_017278.1|WP_041433808.1|1326631_1327372_+|type-III-A-CRISPR-associated-RAMP-protein-Csm3	gnl|CDD|187815	cd09684, Csm3_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein.	2.66379e-97
NC_017278.1|WP_041433806.1|1319805_1321062_+|nitrate/sulfonate/bicarbonate-ABC-transporter-ATP-binding-protein	gnl|CDD|224041	COG1116, TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism].	6.05885e-108
NC_017278.1|WP_014515735.1|1330499_1330769_-|CRISPR-associated-endonuclease-Cas2	gnl|CDD|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	2.12654e-24
NC_017278.1|WP_014515741.1|1337283_1338066_-|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	gnl|CDD|180561	PRK06427, PRK06427, bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed.	4.07997e-131
NC_017278.1|WP_041433991.1|1335730_1337236_-|alkaline-phosphatase	gnl|CDD|224699	COG1785, PhoA, Alkaline phosphatase [Inorganic ion transport and metabolism].	5.934e-93
NC_017278.1|WP_014515744.1|1340303_1341086_-|thiazole-synthase	gnl|CDD|234687	PRK00208, thiG, thiazole synthase; Reviewed.	1.33195e-135

Protein sequences

>NC_017278.1|WP_014515735.1|1330499_1330769_-|CRISPR-associated-endonuclease-Cas2
MKRLYAIAYDIPDDTRRVKLANLLKGYGERVQLSVFECYLDERLLEDLRARARKLLDLSQDALRIYPIQGEVQVLGVGPLVREEAFVVA
>NC_017278.1|WP_014515734.1|1329354_1330503_+|TIGR02221-family-CRISPR-associated-protein
MPKVLLSFLGTGEYKEIPYALDGQEYLTPYTQEALARHYPEHTLKVLLTDAAQKKHGEALRNRVAYEGVSIPDGRTEEELWQIFNAIVEAVPEGASLVVDISHGFRSQPVLALAVVHFLNVAKGVQVERILYGALREQEGRGEFLDLTAFLELLAWTQAARDLAQYGFGKPLGSLLQNLHRQSWLSGGTGPHRLGPLGKTLENLSLSLEVLRVQEASQHAIGLLKALEEVEKDLERAPRSRPLGLLLRFLEERYAPLAVGDPLSPGELPAQAAMVELLLNTGSLAQAAALMRELMVTWLCLQRGFDPVDEREGAEGLLNSWARRAKQKATDEKAQIGQLWNDLANLRNDIAHAGMRKDPTPAQTLAANLKDLWQRVRQVMAP
>NC_017278.1|WP_014515733.1|1328224_1329352_+|type-III-A-CRISPR-associated-RAMP-protein-Csm5
MSFLEAYTLELELLSPVHVGTGEAYPAYAYVPDFERKQVHLLDPSALLLALSPERQKAFLRKVAEGPKGAQDILRHLYREGQIPQEAIRRTLPASQAFLSTIQEATEEATLEYRPLPYSPLGPYLPGSSVKGALRTAWLYWKLVQGGKVLELQGKIWRFRPKGPQDGQTFISLSPKARVGLQENQAFEGEVLGYGRNLYRDPFRAVRLTDSEPAEGFLNRIGIFHPRGKMDGTLLLAETFRIGSRFRFLFRYQGGLAANKGVAGAVPPGELVQALREYYGYVAEWEEDYARNREPKLEKALKVYEQLREKTQDPQTFPIRIGFGSGRLALRLALILPQDHPEAQDPTTRKTAGARKPKDGYPLGWAVGRLVPRKG
>NC_017278.1|WP_014515732.1|1327361_1328228_+|hypothetical-protein
MRASAYYLRFTAPVRALPRASTLLGHLFWWYRYTHGKEALEELLQRLPSLDFRLSSAYPEGWLPRPKLPPLQVEDTTLRKRLKGLALLSFETFQNVAQKGEGALLEAPEVTKNHAPPTPRRLRRTRVGIDRATGGARKGVLFTQDLLFPTGRYAVYALGEPPLDLLEGLRFVGSMGYGGLASVGAGVFQVEGPEAVDLPEAREANAWATLAPSPLEGALYYEPEPYWGRLGGGYVGARPFKKPYLRAKEGSVYRDKNALRLLDVTPSEPPEGARVVEVLQVFPLGVKV
>NC_017278.1|WP_041433808.1|1326631_1327372_+|type-III-A-CRISPR-associated-RAMP-protein-Csm3
MQLRKVMRIRAVLLAKTGIRIGMSRDQMAIGDLDNPVIRNPLTDEPYIPGSSLKGKLRYLLEWSLGGDYILKAKEKHVYASPDPNDPVARIFGLAPENDEKGLEAARKRGPTRLLVRDAYLTPDSKEELERTIARGGYLTEIKQEVFIPRLGGNANPRTTERVPAGARFGVEMVYRVLDEKDEENFHKHVLKALELLELDGLGGHISRGYGQVYFLHPEKPLEAQEGLPLRERLLIQEVPAGHHAG
>NC_017278.1|WP_014515730.1|1326215_1326620_+|type-III-A-CRISPR-associated-protein-Csm2
MATLEFYKDKEKGLLDPTLFERAREKAEELNREGKLKSSQFRNYFAELRALENRFQKERKADEALAFARLVPELELLKAKLAYNTRSQGPLREAKAFVGFLNEALDAGKRSPKDFEAMMKYVEAVLAYFYALGK
>NC_017278.1|WP_014515729.1|1323785_1326215_+|type-III-A-CRISPR-associated-protein-Cas10/Csm1
MTSGLHVALAALVHDLGKLLSRARWGERDEGVPDRTHTAYTAFFVRSHAGLFRKAGVDPAWLEETASRHHEGWQKRPQYQPHTPEAWCVALADTYASQEREEGEGGGSPPEVPLLPATAQLRLMGQEGRKDLGLSPVHALGEGLVPGGPYPEAQPNVRKEAYRRIWERLEARLQTLDALPHLDPEALLLSLAALFQEGLSLVPADTQSEPDVSLYDHLRLTAAIAHALWLYHGQSPRVEELRQDGEKFLLAVGDLGGIQGHIYRIAGAETGVGGIAKRLRARSLEVSLATEAMALGILRKVGLTPLNRIMGAGGKFYLLLPHTQGALEALEGAREAWGRWALADGGSLLPHLAYVPLRGADFRDFAKALSRVHRELALAKLRPFPFLEESQETLRQALRPCAACGLRPAREDAPGSLCPGCEREAEVGGLLPRRDQVGFFLEEAPRPFFGLPGLRVALGPAPGPWAAFHTYRARPDFTPDGTPFEVKPLLGYLPTVEKALKATGMNLEAYQAWVREEGLWEEEGDEHRPLTFSELAALSEGAPYLGGLMLDADRMGEAFATGFRREEKGKDLASPSRMAALSRSLEWFFSVEVLELIQRPGTYAQRLGWDGLEARRKGQRYPLLYSVYSGGDDLFLLGPWDALLDFALDLERLYRLYTQHPALTLSGAFLLFAPKSPVPQMAEALREGEKRAKEAGRGRLFLFGQAVAWDTLRELRAWQEGLRLHLQKERVSKAQVYRWLALWRRFWSEGLDEGERMGYKPLLAYALRRVREKDEGTWKTYLNLLDHQQPAWQYLPVWVQWGLYGERRE
>NC_017278.1|WP_041433807.1|1322993_1323707_-|CRISPR-associated-endoribonuclease-Cas6
MVLAALVLTLEGEAPPEPRGLRGFFYGLLQEVAPEVHDQGENPFALGFGGKEGAYWARFSLLQEGLYARLAPRLFALEGKEVRLGKPFRVRGVLQEGHPWAGVSTYARLFQGEALPDLPLRFASPTFFRRKGVHYPLPEPRLVVESLLRRLEAFGPLKAPEGVREALLERTTVRWFEGKTLKAETEVEAVGFVGKVVYHLPRATEEEARWLQALGRFAFYSGVGAKTGLGYGRARVG
>NC_017278.1|WP_014515727.1|1321125_1322982_+|amino-acid-transporter
MKPNAHPEEGRYPWWQVLCLTGVDLFSSLGYQPGIALLAAGALSPLANLALVLFAFLGVYPVYRRVAEESPHGEGSIGLLTRLIPGWRGKLLVLVVLGFMATDFMLTITLSAADAAVHFLGNPLAPIWLQGHQLGLTLFLVGLLGFVFYLGFREAIGLAVPITLGYLGLNALVLLAALPHVEGEHLEGWWQRLLASHPDPSALVLATLLVFPKLALGLSGYETGVAVMPLIRGRQEDPPEKPWGRIRRTHRLLLAAALIMGFFLVGAGLATALLIPPELWGSEEVSGRALSFLAHRYLGEGFGSLYDLFSIVILWFAGASAMAGLLTIVPRYLPRFGMAPEWARRQRPMVLFFTGVALALTLLFRAEVEAQAAAYATGVLVVMSSAALAAVLLEAQGERKKGAYFWALLPLFLYVLVANIVERPDGVRIASFFIAATLFLSLLSRAFRSFELRVERFQLDEMAESFLEEMRALEAPIRLVAHRPERGGRGVYWEKERRIREATHIPPEDPIYFVEVFVQDPSEFAAEARVWGVEHPDARIFRILGTAAPNTLAAFLLYLRDRLGRRPHIYFEWSEESPLQAALDFLLFGEGDVPTLTHEVLRRAEPNPLRRPLVHVGG
>NC_017278.1|WP_041433806.1|1319805_1321062_+|nitrate/sulfonate/bicarbonate-ABC-transporter-ATP-binding-protein
MFLEAQGVAKAYRAGDKPFPVLEGVNLEVREGEIVALLGRSGGGKSTLLRILAGLIPPDAGEVRFRGKRVEGPAEGMAMVFQTFALFPWLTVWENVALGLEARGVPLEERRRRAREAIALIGLRGFEEALPKELSGGMKQRVGFARALVVDPEILLLDEAFSALDPLTAEGLKGDLLDLWQGGQLRTRAMVLVTHNMEEAVALADRALVLQGSPARIGREIPIPLPHPRDPGDPRFRALVDELYEALTQREEVERRLEEDLLRLPQASVGTLLSLAETLARLGGRVDLPLLAEEGGLEVDDLFPLLEALELLGFARVERGDVELTPAGLAWAQASPEEQKVMFAEHLLRQVPLFARLHQALLQQGRLPEERILLRLQDHLPEPEARRVLQVVREWGRYAGLLVYEEGPRAFRLPAGPA
>NC_017278.1|WP_014515737.1|1332474_1333422_-|CRISPR-associated-endonuclease-Cas1
MTLHLTRQGATLRLKQGRLLLEQEGTIWLSLPARQVRRVAVWGNVRLSTPAWVFLLRQGSPVLFLSLEGFLHGVAGAFPDPHPQHLRAQFSAQPLPLARAFVLGKLRSALAFLQRYELPEAPACAQALAQAEAAPDLDRLRGAEGQGSRAYFAGLARLLSPFGFEGRNRRPPQDPVNAALSYGYALLLGRALLSVRLAGLHPEVGFLHAEGRRSPALALDLMEEFRVPVVDAVVVSAFRRGQLALAHAERRDGGVYLNEEGRRVLIGLLEERFLQEATHPLGFRKPLGELLEVQASRLLGALLGREAYSPFYLKG
>NC_017278.1|WP_014515738.1|1333421_1334627_-|TIGR02710-family-CRISPR-associated-protein
MKVLILTVGTTRAPLEEALAQHTPEGVVFLASQQSFPVAAELQRDYGNSFRHHTLLLEDPESLLESYQAALKALRKALEWEATALIADLTGGTKPMAAGLVLALTGRGVVFSYVGGERRDPETGRVLPGAERLRLLEDPTVRFGLREWAGFTRAWNALNLGMALTELEALLQKPLSPSEERFYRAMRGVVEGLLEWDRFRHPRALELLKPHLPVALAVAEAWGHGAKVRVLRGLEEGLPALEAIVAAQGRPTFALVQDLLANAQRRAEVGRYDDALARLYRTLELVVEADILERLGFVLKDPKTWPEGFPESLRERILRPRGLMELLEAAFDLDLAFGQRGTLAQRLYGEKNRLQALLSRRHESILAHGTRPVEEADYLRLRDFLQDLDERLRPLPPWPKF
>NC_017278.1|WP_155983273.1|1334688_1335696_+|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme
MERVIDDILRPIHGGPDGGPEPLYDFSTNANALGPNPVILEYLRQADPSRYPDPLYRRLRRALAEAHGVAPEQVAVGTGTSELIHRLARWSYLRGPILLLPPTFSEYARAARALDLPLWEARGPEEFLALLPKSALAFLCVPNNPTGEVYPFLEEAAQRAGGALVLDLAYHDLLETPPSLPPGAWRLYSPNKAHGLTGVRSGYLVAPLELEHFQNLAPSWPVSVYGEALLLGHLDPEARAWLEGSRRELHRLRRLLAQGLRGLGLEVRESPANFLLVRVGQATPVARALRERGIRVRDATSFGLPEWLRLSAQGEEAQKALLEALEEVLVGKGAA
>NC_017278.1|WP_041433991.1|1335730_1337236_-|alkaline-phosphatase
MKRRDILKGGLAAGALALLPKGGAQGAPQNQPSLGRRYRNLIVFVYDGFSWEDYAIAQAYARRRLGRVLALERLLARYPNGLMNTFSLTSYVTESSAAGNAFSCGVKTVNGGLAIHADGTRLKPFFAAAKEVGKAVGLVTTTTITHATPASFVVSNPDRNAEAQIAEQYLAFGAEVYLGGGDRFFNPEKRQDKKDMYAEFAKAGYGVAKTPEELARATASKLLGIFSDSHVPYEVDRRFQGVRVPSLKEMVQAALPRLASYRNGFVLQVEAGRIDHSNHLNDPAATLWDVLAADEALEVLTAFVDRNPDTLLILTSDHATGVGALYGAGRSYLESSAGIDLLEPQKASFEHMRRVLGANPDANQVKEAYRAMKGATLSDEEAQMVVEAITKRVYRPDGVRYGIQPDNTMSWALLQKNANKPERPNIGWSSGQHTASPVMLALYGQGLRFLNLGLVDNTHVFRLMGEALGIRYQNPVMSEEEALEILKARPQGMRHPEDVWA
>NC_017278.1|WP_014515741.1|1337283_1338066_-|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase
MRVALTIAGSDSGGGAGVQADLKTFFRFGVYGASALTLVTAQNTLGVEALHLLPPELVYAQIRSVAQDLPLHAAKTGALGDAGIVQAVAEGVRRFGIAPLVVDPVMVAKGGDPLLAPEAVSALKEGLFPLADLITPNSLEAEALLGSPIRTLEEAKAAAMALLELGPRAVLLKGGHLEGEEAVDLLATREGVRAFSAPRVRTRNTHGTGCTLSAAITALLAQGKPLEEAVAQAKAYLTRALETAPPLGQGHGPLNHFASP
>NC_017278.1|WP_014515742.1|1338076_1339381_-|phosphomethylpyrimidine-synthase-ThiC
MTQLEAAKKGRITEEMAYVAEQEGVSPEWVRQGVAAGRIVIPRNPNHKTLRDFKGIGEGLSVKVNANLGTSYDYVDLEAEVEKARVAIRYGADTLMDLSTGGDLKAIRRRILEVATVPLGTVPIYEAEFRAAKRKNFFDMSADELLQVIEEHGREGVDYITVHAGVTLRNLEVYRQARRTTGIVSRGGGLMAAWMLHRGEENPLYARFDDLLDIARTYDLTLSLGDGLRPGSLADSTDRAQIAELLTIGELVERARRAGVQAMVEGPGHIPLSEVAANVQIQKKLTGHAPFYILGMLPVDTAAGFDHIAGAIGGALAGWWGADMLCYLTPAEHLGLPTAEHVKEGVIAFKIAAHAADVARGNPRALERNRKMSEARYRLDWEGQFALCLYPEEARRLREERGSRTKACSMCGPFCPMNLVEAVLRGQGQGLPLA
>NC_017278.1|WP_014515743.1|1339377_1340307_-|FAD-dependent-oxidoreductase
MRAEVAVVGAGIIGALAAYELRKRGLEVLLLDAGKEGAATLASAGMLAPHPEGLSGELLQAGLWALEYYPALLEELLARGFRVEAGFSGVGVVALSGAEREAWGAEGAPPYPVRGGQGYRAFPGGYVHPRALREALLEALKAMGVTLLWAEVERVAEGRVFWREGEARARAILLAVGAWGGRFGLPVRPLKGEALLLEGPAPPLPLFAGEGYLLPREGGVYVGATQREGFGGGVDLWGLRFLADYAHERFPLLEGAPFRGVVYGYRPLGEVFVGQVEGNVWAAVGHGRNGVLLAPWTARRLLGLLGVEG
>NC_017278.1|WP_014515744.1|1340303_1341086_-|thiazole-synthase
MDTWQVGGITLRSRLILGSGKFRDFGVMREAIKAAGAEVVTVSVRRVEVGAPGHVGLLEALEGVRLLPNTAGARTAEEAVRLARLGRALTGEGWVKLEVIPDPAYLLPDPLETLKAAERLLEKGFTVLPYMGPDLVLARRLAALGTATVMPLAAPIGSGWGVRTRALLELFARERAGLPPVVVDAGLGLPSHAAEVLEMGLDAVLVNTAIAEAKDPPAMAEAFRLAVEAGRKAFLAGPMRPREGASPSSPTAGVPLGREG
>NC_017278.1|WP_014515745.1|1341086_1341281_-|sulfur-carrier-protein-ThiS
MVWLNGEAKPLEGRELREVLAEMGVDLGRVAVLLNEEAYPGRDLPPHVLREGDVVEVVALMQGG
>NC_017278.1|WP_014515746.1|1341267_1341888_-|thiamine-phosphate-synthase
MQGRLYLVVTPRPGWTWEEVLDRTERALAGGVEVLQLRAKDWEARPILELGERMGLLARRYGVPFFLNDRPDLAALLGADGVHLGQGDLRPEEARRFFGGLVGRSTHAPEQALKALEEGADYLSVGPVWETPTKPGRPAAGLGYVRWAAAHLGEKPWFAIGGIDLGNLDQVLATGARRVVVVRAILDAEDPEGAARAFRERLYGVA

Crispr_ID: NC_017278_7

• CRISPR_ID: NC_017278_7
• CRISPR_location: 1414650-1415585
• CRISPR_type: Orphan
• Repeat_type: III-A
• Spacer_info: 12 spacers

Consensus repeat of NC_017278_7

Consensus_repeat	Method
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	CRISPRCasFinder
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	CRT
GTTGCAAAAGTGGCTTCCCCGTAAGGGGATTGCGAC	PILER-CR

spacers of NC_017278_7

>7.1|1414686|41|NC_017278|CRISPRCasFinder,CRT
ATCCGGTTCATCAGGCCGAGGGCCGCCACCATCCCGGAGCC
>7.2|1414763|33|NC_017278|CRISPRCasFinder,CRT,PILER-CR
CCATGAAGAAACTCAACTTGGCGGCCATCGTGT
>7.3|1414832|38|NC_017278|CRISPRCasFinder,CRT,PILER-CR
CCGGATGGTGGCTTCGCTACACCATCCAAAATGGAGGG
>7.4|1414906|36|NC_017278|CRISPRCasFinder,CRT,PILER-CR
GGCACGATACGCCCTCCTGCGGGGGGAGCGGGAGTG
>7.5|1414978|39|NC_017278|CRISPRCasFinder,CRT,PILER-CR
CCCGGTCCGACGGGGCATGTGGGCGAATACCACATCATG
>7.6|1415053|40|NC_017278|CRISPRCasFinder,CRT,PILER-CR
TAGTAGTGATGGTAGAGATAGGCAGGCGGATAAGGGAGCT
>7.7|1415129|42|NC_017278|CRISPRCasFinder,CRT,PILER-CR
CGGCGAGGTAAGGGTGGGGTCGTTTTCCGGCCCCACCGGCTA
>7.8|1415207|41|NC_017278|CRISPRCasFinder,CRT,PILER-CR
CGGCGCCTCCTCAAGGTCCCCCTTCCCCCCACGCGCTACGA
>7.9|1415284|41|NC_017278|CRISPRCasFinder,CRT,PILER-CR
AGGTAGGGGAGAAGGCCGGAAACCTGGAGGCTACGCCTGCC
>7.10|1415361|40|NC_017278|CRISPRCasFinder,CRT,PILER-CR
CTGTTCCACAGAAGAAGGGGGCCCCCGCTAAGGGGAAGGA
>7.11|1415437|38|NC_017278|CRISPRCasFinder,CRT,PILER-CR
TTGTCCACGCTCCTGAGCCTGGGATGGGGCCGGGGTGG
>7.12|1415511|39|NC_017278|CRISPRCasFinder,CRT,PILER-CR
CAAGGGCAAGCTGGGGTGGATCGTGAGAGGGAGGGCCTC

CRISPR arrays and Neighbor proteins around NC_017278_7

CRISPR arrays

The CRISPR arrays of NC_017278_7

>merge|NC_017278|7|1414650-1415585|CRISPRCasFinder,CRT,PILER-CR
ACCGCAATCCCCTTACGGGGAAGCCACTTTTGCAACATCCGGTTCATCAGGCCGAGGGCCGCCACCATCCCGGAGCCGTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAACCCATGAAGAAACTCAACTTGGCGGCCATCGTGTGTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAACCCGGATGGTGGCTTCGCTACACCATCCAAAATGGAGGGGTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAACGGCACGATACGCCCTCCTGCGGGGGGAGCGGGAGTGGTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAACCCCGGTCCGACGGGGCATGTGGGCGAATACCACATCATGGTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAACTAGTAGTGATGGTAGAGATAGGCAGGCGGATAAGGGAGCTGTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAACCGGCGAGGTAAGGGTGGGGTCGTTTTCCGGCCCCACCGGCTAGTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAACCGGCGCCTCCTCAAGGTCCCCCTTCCCCCCACGCGCTACGAGTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAACAGGTAGGGGAGAAGGCCGGAAACCTGGAGGCTACGCCTGCCGTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAACCTGTTCCACAGAAGAAGGGGGCCCCCGCTAAGGGGAAGGAGTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAACTTGTCCACGCTCCTGAGCCTGGGATGGGGCCGGGGTGGGTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAACCAAGGGCAAGCTGGGGTGGATCGTGAGAGGGAGGGCCTCGTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC

>NC_017278|7|7|1414650-1415585|CRISPRCasFinder
ACCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	ATCCGGTTCATCAGGCCGAGGGCCGCCACCATCCCGGAGCC
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	CCATGAAGAAACTCAACTTGGCGGCCATCGTGT
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	CCGGATGGTGGCTTCGCTACACCATCCAAAATGGAGGG
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	GGCACGATACGCCCTCCTGCGGGGGGAGCGGGAGTG
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	CCCGGTCCGACGGGGCATGTGGGCGAATACCACATCATG
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	TAGTAGTGATGGTAGAGATAGGCAGGCGGATAAGGGAGCT
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	CGGCGAGGTAAGGGTGGGGTCGTTTTCCGGCCCCACCGGCTA
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	CGGCGCCTCCTCAAGGTCCCCCTTCCCCCCACGCGCTACGA
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	AGGTAGGGGAGAAGGCCGGAAACCTGGAGGCTACGCCTGCC
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	CTGTTCCACAGAAGAAGGGGGCCCCCGCTAAGGGGAAGGA
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	TTGTCCACGCTCCTGAGCCTGGGATGGGGCCGGGGTGG
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	CAAGGGCAAGCTGGGGTGGATCGTGAGAGGGAGGGCCTC
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC

>NC_017278|7|7|1414650-1415585|CRT
ACCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	ATCCGGTTCATCAGGCCGAGGGCCGCCACCATCCCGGAGCC
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	CCATGAAGAAACTCAACTTGGCGGCCATCGTGT
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	CCGGATGGTGGCTTCGCTACACCATCCAAAATGGAGGG
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	GGCACGATACGCCCTCCTGCGGGGGGAGCGGGAGTG
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	CCCGGTCCGACGGGGCATGTGGGCGAATACCACATCATG
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	TAGTAGTGATGGTAGAGATAGGCAGGCGGATAAGGGAGCT
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	CGGCGAGGTAAGGGTGGGGTCGTTTTCCGGCCCCACCGGCTA
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	CGGCGCCTCCTCAAGGTCCCCCTTCCCCCCACGCGCTACGA
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	AGGTAGGGGAGAAGGCCGGAAACCTGGAGGCTACGCCTGCC
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	CTGTTCCACAGAAGAAGGGGGCCCCCGCTAAGGGGAAGGA
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	TTGTCCACGCTCCTGAGCCTGGGATGGGGCCGGGGTGG
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	CAAGGGCAAGCTGGGGTGGATCGTGAGAGGGAGGGCCTC
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC

>NC_017278|7|7|1414727-1415585|PILER-CR
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	CCATGAAGAAACTCAACTTGGCGGCCATCGTGT
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	CCGGATGGTGGCTTCGCTACACCATCCAAAATGGAGGG
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	GGCACGATACGCCCTCCTGCGGGGGGAGCGGGAGTG
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	CCCGGTCCGACGGGGCATGTGGGCGAATACCACATCATG
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	TAGTAGTGATGGTAGAGATAGGCAGGCGGATAAGGGAGCT
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	CGGCGAGGTAAGGGTGGGGTCGTTTTCCGGCCCCACCGGCTA
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	CGGCGCCTCCTCAAGGTCCCCCTTCCCCCCACGCGCTACGA
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	AGGTAGGGGAGAAGGCCGGAAACCTGGAGGCTACGCCTGCC
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	CTGTTCCACAGAAGAAGGGGGCCCCCGCTAAGGGGAAGGA
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	TTGTCCACGCTCCTGAGCCTGGGATGGGGCCGGGGTGG
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC	CAAGGGCAAGCTGGGGTGGATCGTGAGAGGGAGGGCCTC
GTCGCAATCCCCTTACGGGGAAGCCACTTTTGCAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_017278.1|WP_014515826.1|1419517_1419916_-|acyl-CoA-thioesterase	unknown	unknown	gnl|CDD|223894
NC_017278.1|WP_014515824.1|1416005_1418267_-|ribonuclease-R	unknown	unknown	gnl|CDD|273947
NC_017278.1|WP_014515827.1|1419903_1420179_-|ribosome-binding-factor-A	unknown	unknown	gnl|CDD|223927
NC_017278.1|WP_014515821.1|1411620_1412226_-|dephospho-CoA-kinase	unknown	unknown	gnl|CDD|366476
NC_017278.1|WP_014515814.1|1405502_1406279_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|213191
NC_017278.1|WP_014515816.1|1407045_1408899_+|AMP-binding-protein	unknown	unknown	gnl|CDD|341296
NC_017278.1|WP_155983322.1|1413607_1414588_+|AmmeMemoRadiSam-system-protein-B	unknown	unknown	gnl|CDD|280116
NC_017278.1|WP_014515818.1|1409964_1410507_-|glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl|CDD|376884
NC_017278.1|WP_014515820.1|1410923_1411616_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|235990
NC_017278.1|WP_155983275.1|1425443_1426712_+|nodulation-protein-NfeD	unknown	unknown	gnl|CDD|223961
NC_017278.1|WP_014515830.1|1424019_1424592_-|YigZ-family-protein	unknown	unknown	gnl|CDD|224653
NC_017278.1|WP_014515833.1|1426714_1427692_+|flotillin-like-protein-FloA	unknown	unknown	gnl|CDD|237462
NC_017278.1|WP_014515817.1|1408900_1409968_+|branched-chain-amino-acid-ABC-transporter-permease	unknown	unknown	gnl|CDD|119323
NC_017278.1|WP_041434001.1|1424595_1425390_-|shikimate-dehydrogenase	unknown	unknown	gnl|CDD|223247
NC_017278.1|WP_041433999.1|1410506_1410914_-|SufE-family-protein	unknown	unknown	gnl|CDD|376883
NC_017278.1|WP_014515825.1|1418268_1419513_-|aspartate-aminotransferase-family-protein	unknown	unknown	gnl|CDD|227325
NC_017278.1|WP_014515815.1|1406289_1407039_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|213186
NC_017278.1|WP_014515828.1|1420188_1421490_-|phosphoglucosamine-mutase	unknown	unknown	gnl|CDD|184620
NC_017278.1|WP_014515822.1|1412205_1413501_+|HDIG-domain-containing-protein	unknown	unknown	gnl|CDD|131739
NC_017278.1|WP_014515829.1|1421514_1424016_-|DNA-polymerase-I	unknown	unknown	gnl|CDD|273160

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_017278.1|WP_014515826.1|1419517_1419916_-|acyl-CoA-thioesterase	gnl|CDD|223894	COG0824, FcbC, Predicted thioesterase [General function prediction only].	3.39206e-33
NC_017278.1|WP_014515824.1|1416005_1418267_-|ribonuclease-R	gnl|CDD|273947	TIGR02063, Ribonuclease_R, ribonuclease R. This family consists of an exoribonuclease, ribonuclease R, also called VacB. It is one of the eight exoribonucleases reported in E. coli and is broadly distributed throughout the bacteria. In E. coli, double mutants of this protein and polynucleotide phosphorylase are not viable. Scoring between trusted and noise cutoffs to the model are shorter, divergent forms from the Chlamydiae, and divergent forms from the Campylobacterales (including Helicobacter pylori) and Leptospira interrogans. [Transcription, Degradation of RNA].	0
NC_017278.1|WP_014515827.1|1419903_1420179_-|ribosome-binding-factor-A	gnl|CDD|223927	COG0858, RbfA, Ribosome-binding factor A [Translation, ribosomal structure and biogenesis].	9.99183e-18
NC_017278.1|WP_014515821.1|1411620_1412226_-|dephospho-CoA-kinase	gnl|CDD|366476	pfam01121, CoaE, Dephospho-CoA kinase. This family catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form Coenzyme A EC:2.7.1.24. This enzyme uses ATP in its reaction.	4.10432e-69
NC_017278.1|WP_014515814.1|1405502_1406279_+|ABC-transporter-ATP-binding-protein	gnl|CDD|213191	cd03224, ABC_TM1139_LivF_branched, ATP-binding cassette domain of branched-chain amino acid transporter. LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ). ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules.	2.95445e-95
NC_017278.1|WP_014515816.1|1407045_1408899_+|AMP-binding-protein	gnl|CDD|341296	cd17641, LC_FACS_bac1, bacterial long-chain fatty acid CoA synthetase. The members of this family are bacterial long-chain fatty acid CoA synthetase, most of which are as yet uncharacterized. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.	0
NC_017278.1|WP_155983322.1|1413607_1414588_+|AmmeMemoRadiSam-system-protein-B	gnl|CDD|280116	pfam01875, Memo, Memo-like protein. This family contains members from all branches of life. The molecular function of this protein is unknown, but Memo (mediator of ErbB2-driven cell motility) a human protein is included in this family. It has been suggested that Memo controls cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton.	4.89662e-75
NC_017278.1|WP_014515818.1|1409964_1410507_-|glycerol-3-phosphate-acyltransferase	gnl|CDD|376884	pfam02660, G3P_acyltransf, Glycerol-3-phosphate acyltransferase. This family of enzymes catalyzes the transfer of an acyl group from acyl-ACP to glycerol-3-phosphate to form lysophosphatidic acid.	2.08405e-36
NC_017278.1|WP_014515820.1|1410923_1411616_-|SDR-family-oxidoreductase	gnl|CDD|235990	PRK07326, PRK07326, SDR family oxidoreductase.	5.07869e-103
NC_017278.1|WP_155983275.1|1425443_1426712_+|nodulation-protein-NfeD	gnl|CDD|223961	COG1030, NfeD, Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones].	9.3938e-71
NC_017278.1|WP_014515830.1|1424019_1424592_-|YigZ-family-protein	gnl|CDD|224653	COG1739, COG1739, Uncharacterized conserved protein [Function unknown].	5.91529e-57
NC_017278.1|WP_014515833.1|1426714_1427692_+|flotillin-like-protein-FloA	gnl|CDD|237462	PRK13665, PRK13665, hypothetical protein; Provisional.	0
NC_017278.1|WP_014515817.1|1408900_1409968_+|branched-chain-amino-acid-ABC-transporter-permease	gnl|CDD|119323	cd06581, TM_PBP1_LivM_like, Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of branched-chain amino acids (AAs). These types of transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. E. coli LivM forms a heterodimer with another TM, LivH, to generate the transmembrane pore. LivH is not included in this subgroup. The LIV-1/LS transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) or LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine.	1.4879e-68
NC_017278.1|WP_041434001.1|1424595_1425390_-|shikimate-dehydrogenase	gnl|CDD|223247	COG0169, AroE, Shikimate 5-dehydrogenase [Amino acid transport and metabolism].	1.59771e-96
NC_017278.1|WP_041433999.1|1410506_1410914_-|SufE-family-protein	gnl|CDD|376883	pfam02657, SufE, Fe-S metabolism associated domain. This family consists of the SufE-related proteins. These have been implicated in Fe-S metabolism and export).	7.58636e-32
NC_017278.1|WP_014515825.1|1418268_1419513_-|aspartate-aminotransferase-family-protein	gnl|CDD|227325	COG4992, ArgD, Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism].	0
NC_017278.1|WP_014515815.1|1406289_1407039_+|ABC-transporter-ATP-binding-protein	gnl|CDD|213186	cd03219, ABC_Mj1267_LivG_branched, ATP-binding cassette component of branched chain amino acids transport system. The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E. coli branched-chain amino acid transporter. MJ1267 contains an insertion from residues 114 to 123 characteristic of LivG (Leucine-Isoleucine-Valine) homologs. The branched-chain amino acid transporter from E. coli comprises a heterodimer of ABCs (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ).	4.69819e-110
NC_017278.1|WP_014515828.1|1420188_1421490_-|phosphoglucosamine-mutase	gnl|CDD|184620	PRK14323, glmM, phosphoglucosamine mutase; Provisional.	0
NC_017278.1|WP_014515822.1|1412205_1413501_+|HDIG-domain-containing-protein	gnl|CDD|131739	TIGR02692, putative_tRNA_nucleotidyltransferase, tRNA adenylyltransferase. The enzyme tRNA adenylyltransferase, also called tRNA-nucleotidyltransferase and CCA-adding enzyme, can add or repair the required CCA triplet at the 3'-end of tRNA molecules. Genes encoding tRNA include the CCA tail in some but not all bacteria, and this enzyme may be required for viability. Members of this family represent a distinct clade within the larger family pfam01743 (tRNA nucleotidyltransferase/poly(A) polymerase family protein). The example from Streptomyces coelicolor was shown to act as a CCA-adding enzyme and not as a poly(A) polymerase. [Protein synthesis, tRNA and rRNA base modification].	2.93907e-48
NC_017278.1|WP_014515829.1|1421514_1424016_-|DNA-polymerase-I	gnl|CDD|273160	TIGR00593, DNA_polymerase_I, DNA polymerase I. All proteins in this family for which functions are known are DNA polymerases Many also have an exonuclease motif. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair].	0

Protein sequences

>NC_017278.1|WP_155983322.1|1413607_1414588_+|AmmeMemoRadiSam-system-protein-B
MEGRTLREVQEEVFRAHGVLVPMEELEGLARALEEAGLLLTEGVEQRLKEEEEKLKRERPMRLAGISYPEGEGEARAFLEAFRASFTGEGVGAEVLLLPHLEPSRVPEAYGAALAALEKTPPPERVYLVGVAHRPLKERAAALPVPFQTPFGPALPDLEALQALDALLPFELFNTPLAFREEHSLELPLLFLKGAYPEARFLPLLVGRRSPELGEALKVVLRDYPGLLVLAVDLSHVGPRFGDPPLSRSLAEEARKRDLGFLEGLAQGEPEAALARLGANPTRLDATEVVASLAPLLRGRRGQVLAYRLDLEAATLSAVGAGTLAF
>NC_017278.1|WP_014515822.1|1412205_1413501_+|HDIG-domain-containing-protein
MLRLIAHLDFPFYTPKGAYPVGGAVRDLLLGRRPKDLDFAAQDPLRAAEEAQRRLGGSLFPLDEARGQYRLVVGSSTLDFAPVEGTLEEDLSRRDFRLNALLWRRGRVFGLAGVEEDLAKRLLRPVAEENLYQDHLRSLRAVRLAATLGLGLPRATREALRRHARFLLAHPEALPARERVREELARLLLSPRAAWGFHTLGETGLLEVYLPELKPLWGLHQGGVHHLDGWRHTLSVLFHLGWLWPEAPLRARLAALYHDVGKPLTRRFDPEVGRFRFLGHAEVGAEVAHASLLWLRFPKEVAEGVRELVRRHMDHPPEEARALRRFYLRRKGLLPDLPYLMAADRLAARGVEGEAWTLLEDYQEALAEPLPERPLLSGEEAMALLGLKPGPEVGQALEALLLAQAEGRVRNREEAAAFLLYWKGGREATAT
>NC_017278.1|WP_014515821.1|1411620_1412226_-|dephospho-CoA-kinase
MGDEAKHPIIIGITGNIGSGKSTVARFLRAWGYPVLDLDGLAERARERRKEELKRLFPGAFRGEELDRRALAQEVFADPKRLQALEAVLHPEIRRLLEEEVARLEAPLLFLEIPLLFEKGWEGRLAGTLLVAAPLEVRLERAMARSGLSREEVLARERAQMPEEEKRKRATWVLENTGSLEDLEAGLREILSDIRARFGVR
>NC_017278.1|WP_014515820.1|1410923_1411616_-|SDR-family-oxidoreductase
MRVALVSGASRGIGEAIARHLHARGYRVGLLARDGERLGALAAELGEGALPLPGDVRRLGDWERAVARVLEAFGRLDALVNNAGIGIMKPLEELSEAEFREVLEVNLLGPFLGLKAALPALLASRGVVVNVASLAGKHPFKGGGAYNASKFGLLGLMGAALLELREKGVRVVNLLPGSVDTGFAGNTPGASWKLAPEDVAQAVLFALEMPERALVSEMELRPTQVPAKGG
>NC_017278.1|WP_041433999.1|1410506_1410914_-|SufE-family-protein
MALPPKLQAALDLLRAMPKELKTQVLLDYAKKVPTPPKEVELERVHECQTPFFLKAWVEEGRVRLHFFVPDEAPTVKAFAGLLKEGLEGEPPEAVLAVPPGFYRGAGLEDLLTPLRLRGLEAALLRLQEQVRKSL
>NC_017278.1|WP_014515818.1|1409964_1410507_-|glycerol-3-phosphate-acyltransferase
MFLALLLGYFLGSFPVAYWFGALRGRNVLREGSGNPGALNAYRLLGPVPGLMVLFLDLFKGLLAVALGEGAAGSPLGGLLGGVGAVWGHAFSPWLLFRGGKALATGAGVLLAVDPRILLLALLLFALLYLLSRRPYRSALAVALALPLLSTLLGHALPHLLFGLGVGLPVALRHLKDWDR
>NC_017278.1|WP_014515817.1|1408900_1409968_+|branched-chain-amino-acid-ABC-transporter-permease
MYALAKHLADAFSRRYARAVRETYREDEAYASTPLGRVALFLFLVLLFLLPLFLGPYPMYVATLVGIGALSALGLHLLVGGAGQISLGHAAFMGVGAYAASHLFGPLAPLGILLGGGIAALLGLVLALPSLRIKGVYLAIATLAFQFLADYVFKNWEAVTGGIRGRTLPPPELLGLPLDSPERLWYLLLLFALPLFFYGKRLLMTRAGRAFMAVRDNDLSARVAGVDLTRVKLLAFALSAFYAGVAGGLLAQLYKAVTPEYFPLSVSIQYLAMVIVGGAGTVLGAVLGAFFVLLIPEVLNSYVGALGPQYAAALAAWRNVIFGLLILFFLILEPLGLVGLWGRIRNYFRTWPLPY
>NC_017278.1|WP_014515816.1|1407045_1408899_+|AMP-binding-protein
MKGTLLEHLYRHAKERPEAPALRVKRLGVWQKTSWKDLLDRVLRLAGGLQALGLKEGEVLAILGHNAPEWVEAELAAQALGALPMGIYADAMPEEVGYFLEFTGARGIVVSDEEQLDKVYPHLHLLDFVLVWEEAGMTRHFRGKVRRFSEALGDPRVGEEALKRRRPEETALLAPTSGTTGRSKLAMLSHRNLLAGHEAVGRALGFQKGAWVFSYLPLPWIGEQMLTVVQSLVEGSTVHFPEDPTTLREDLKEVQPDFFLAPPRLWEDMASLIQSRMADADFLKAFFFRVGMGALLEGAQREFRGEKVGLWLDLKRALFYPLIARPLRARLGLAACRIAVTGGAPLGGEVFTFFRALGLDIRQVYGQSETAAATTAHATGDAPPETVGPPLPGTEVRLSEEGEILVRGPQVFQGYFRQEKATAESFTEDGFFRTGDAGFFDERGHLVILGRVKEVGALLDGTRFAPQFLENRLKYSPYIREAVVLGHGKPFVSALIELDPENVQNWARKRGIPFTTYLSLTERPEVKALIAEEIRMVNRTLPEKLRIQRFALLPKELHPDDEEITRTRKVRRQVVETRYGPVIQALYGEGGRVELTLPIRYLEGEGRLSASLEVQEV
>NC_017278.1|WP_014515815.1|1406289_1407039_+|ABC-transporter-ATP-binding-protein
MEPILETRNLHLSFKGVKALTGVEFAVHKGEFFAVIGPNGAGKTTLLNVLSGVYEPERGEVFFLGQSLKGKSPQERARMGLGRTFQGLEIFRGMSVLDNVKLGAELALPAYPLALPRREREERLRAWAEEVLDYLHLSPFRHLPAGMLPYGLQKRVEVARALAGRPQLLLLDEPMAGLSLEEKQDLARFLLDAREEWGVTLLWVEHDLRAVLELSDRVLVLSYGEALYYGPPEGVRRDPKVVEAYLGHA
>NC_017278.1|WP_014515814.1|1405502_1406279_+|ABC-transporter-ATP-binding-protein
MLSVANLKVVYRGVILALDGVSLEVRDGEAVALLGPNGAGKSSLVRALAGLLPKFEGRVLDGHIHLFGQETTHLDPVRISRLGLTAVLEGRPLFRYLTPVENLVAAGHRLPPRELKEGMEEVFARFPRLYERRHEQAGYLSGGEQQMLLLGMALLTRPKVLVVDEPSLGLAPRLVEEVMRTLDALRREKGLSLLLVEQNARAALAVVDRVYVLERGRVVFEGDAKAAQEDQDVMEFYLGKEEVGFRQARRYRRRKRWV
>NC_017278.1|WP_014515824.1|1416005_1418267_-|ribonuclease-R
MQETLLEFFKKTGKPHRLEEILRRFGLEKREAKAYLKALVREGLLEKKGSQYFLPAKVQGPISLHRDGYGFVRLPEGDLFIPPGYTLDAWPEDVVEARLMPPGRDGRPWGAVERVVRRARERVVGTLDFRRGYALLLPDEPGLPELRLLPEGLEGLERGSRILVRVHYGKRPYGEFLEYLGKGEAPETETEAVIAKYGLRAAFPEEVLKEAEAIPLEIPEEELGRREDFRALRVFTIDGVDAKDFDDAIHIERLPKGFRVGVHIADVSHYVREGSPLDQEAFLRGTSVYLPGRVLPMLPERLSNGVCSLKPGEDRLVLSALFELGEDLKVKRVRFVEGVIRSVARLTYTEVEAFAEGFGLPEAHAFLAEDLSLLLDLTARLRQKRLEAGALDFSFPEVKVEVEDGTLHLIPQQEPRARSLIEELMLLANRAVAEHLVKKGLPALFRVHEEPLEEAYAKLRQALARLGYSLPEALSPKALQGVLLEAKGRPEEPVVAGLVLRSLRLARYAAENLGHFGLAMEHYLHFTSPIRRYPDLVVHRVLKAALRRTLTPAKKARWLETFPSVAEHASERERKAEAAERELTKYYMARWAELHLGQRFTGNVTGVASFGAFVMLKNGVEGLVRLEALGPYTYSEEAMALLGPKGRRIRLGDELEVVVAGANPRLRQVDFVPFREEEKPAYAEGPAKEQPPAKRGRKEVGMRKVVGPPKERHRDDRPERATVHTVYFGEWQPKEERRTEPAPTRPKRRRRRR
>NC_017278.1|WP_014515825.1|1418268_1419513_-|aspartate-aminotransferase-family-protein
MGMDPFTLFERHVNPGLAGLLRFTGLDRVESHAEGPYVWDTTGKRYLDFLGLYGTLNLGHRHPKVVEAVKRQLDRMPMSVRVLVSEPTARLAARLAEITPEGLEMVFFGNSGAEAVEAAIKLARAYTGKPGIVTTQGGFHGKTMGALSLTPKPEYQDPARPLLPGVKAVPYGDLEALEAAIDDQTAAVIVEPIQGEGGIRVPPEGYLRGVRELTRRRGVLMIADEVQTGLGRTGKLFGVDWEGVAPDLMTLAKALGGGVMPIGACVGRREIFEVFKTNPLYHSSTFGGNPLAAAAALAAIEVTLEERLPERALEVGGYLMEGLKGLQREHPALIQEVRGRGLMLGVEFTDADIGALVVAELAERGVITAFGLNNPKVVRLEPPLIIGREHADEALSAFSESLKATEKALEGLLG
>NC_017278.1|WP_014515826.1|1419517_1419916_-|acyl-CoA-thioesterase
METLTRIKVRYAETDQMGVVHHAVYPVYLEAARVDFLEQAGLPYHLVEARGVYFPVVELALTFRAPARFGEEVLVRTRLAGLSWRDLSFAYRVEREGVLLAEGRTRHLCQVGGRAGRMPEDLYRALSVLHLG
>NC_017278.1|WP_014515827.1|1419903_1420179_-|ribosome-binding-factor-A
MYGRAHLEERLKRALAEAIQGLEDPRLFLLTVEAVRLSPDGRVLTAYVEAFQEEAKALQALGHAKGRLLAALARRVRLRRLPELEFLPWRP
>NC_017278.1|WP_014515828.1|1420188_1421490_-|phosphoglucosamine-mutase
MRRYFGTDGVRGEAGKPPLTPEFVLKLGQAAGAYFRKQEARPVVLLAKDTRESSDLLEAALAAGLLSQGVRVEHLGVLPTPGVAYLTKALGATAGAMISASHNPYQDNGIKFFGPTGEKLPDEAEAEVEALLEEAHPTRGIGTVGDFREAERMYLDFLLAHAPDLTGLRLGLDLAHGATYRLGPKLFQRAGAEVMAFFNTPDGRNINKGCGSTHPEALARFVVELGLDLGIAFDGDGDRVQFLDRKGRLFHGDHILYLAALAYGERGVVGTVMSNMGLEVALKERGIAFHRAAVGDRYVLETLKAQDLSLGGEPSGHVIFRRHHTTGDGLLTALLTLKALKALGGDLADWYQALPMFPQVLLNVRVADKAKVMAHPRLKEALEEAEARLGGRGRVNVRPSGTEPVVRVMVEAEEGAEALAQELAHLVAALDRE
>NC_017278.1|WP_014515829.1|1421514_1424016_-|DNA-polymerase-I
MLPLFAPKGRILLVDGHHLAYRTFFALKGLTTSRGEPVQGVYGFAKALLKALKEVKGDGDGVIVVFDAKAPSFRHQAYGAYKAGRAPTPEDFPRQLSLIKELVDLLGLVRLEVPGYEADDVLATLARRAEGEGYEVRILTADRDLYQLLSERVSILHPEGHTITPQWLWEKYGLRPEQWVDYRALSGDPSDNLPGVKGIGEKTAAKLLQEWGSLENLLKNLDRVKPPSIREKIQAHLEDLRLSQDLARVRTDLPLEVDFAGRREPDREGLRAFLERLEFGSLLHEFGLLEGPKAAEEAPWPPPPGAFVGYVLSRPEPMWADLLALAAAQEGRVHRAPEALAGLRALGEVRGLLAKDLAVLALREGLEIPPGDDPMLLAYLLDPSNTSPEGVARRYGGEWAEEAGERALLAERLQAALWARLEGEERLRWLYEEVEKPLSRVLARMEATGVRLDVAYLQALALEVEGEVRRLEEEVFRLAGHPFNLNSRDQLEKVLFDELGLPAIGKTEKTGKRSTSAQVLELLREAHPIVARILEYRELTKLKSTYIDPLPALVHPRTGRLHTRFNQTATATGRLSSSDPNLQNIPVRTPLGQRIRRAFVAEEGWVLVALDYSQIELRVLAHLSGDENLIRVFQEGRDIHTQTASWMFGVPPEAVDPLMRRAAKTINFGVLYGMSAHRLSGELAIPYEEAVAFIERYFQSYPKVRAWIEKTLEEGRRRGYVETLFGRRRYVPDLNARVKSVREAAERMAFNMPVQGTAADLMKLAMVRLFPLLPGVGARMLLQVHDELLLEAPKERAEEVARLAREVMEGVWPLAVPLEVEVGIGEDWLAAKG
>NC_017278.1|WP_014515830.1|1424019_1424592_-|YigZ-family-protein
MARFTLAAPWEVQKLIQKSRFLAKVAPVASEEEALAFLQRHRKPEATHNVYAYKLGPRSRFSDDGEPAGTAGRPVLQAIEAQSLDRVAVLVVRYFGGVKLGAGGLVRAYAGVAAEALRQAPKVPLVERVAVRLLVPFAQVGRAYGVLRGLEVAEAYAPEGVLLTFLVPHSQAEALVRAVGEATRGQARRM
>NC_017278.1|WP_041434001.1|1424595_1425390_-|shikimate-dehydrogenase
MLRLAVLGHPVAHSLSPAMHRYALESLGLPGRYEAWETPLEALPERLAQVRQGFRGVNLTLPLKEAALPLLDWVAPEARAMGAVNTVLSLEGRLFGFNTDAPGFLAALRAGGIPLVGPALVLGAGGAARAVAYALKGAGLRVWVWNRTPERAQALAEALGLEAVPLERAPEARLLVNATSVGLGDPEATPLPPELFPQEGAAVDLVYRPLWTRFLREARARGLKVQTGLPMLAWQGALAFRIWTGLLPDAAGMERVALKALGED
>NC_017278.1|WP_155983275.1|1425443_1426712_+|nodulation-protein-NfeD
MRAVKRLLALWFLLALAWGKTYLVPIQGEIDPALAVFVEQALSRAEREGASAVAFLIDTPGGRVDAAIRISDRILQTPLPTLAVVQNAFSAGALIALSCRQIAMLPGSEIGAALPVVAPPLGQPQAADQKVISALKGKFRAVAEARGRPVELAEAMVDPAKEIPGLSAKGEPLTLSADKAVELKVADFRAASLPEALRQAGLSPETERLEPGPRVQVARFLTSSTVAGLLLALGLLLLLLELFTPGFGVMGALGLAFLALYFAGGWLAGLSGAFELLLFFLGVALLLAEAFLFPGFGLAGALGVGAILASVYFTFGENALVVIAIAVIALGLGLLLVFRFLPRTRPARALVLESAISEHATEEAVAVGSVGTALTDLRPGGVARFGGRRVDVVANRGFIPKGTPIRVVEVRGPTVLVEALEE
>NC_017278.1|WP_014515833.1|1426714_1427692_+|flotillin-like-protein-FloA
MEGLGVLFLAFIVLILVFLFFSFIPVGLWISAWAAGVRVPLLTLVAMRLRRVPPARIIYPLIKATKAGLDVRLDRLEAHYLAGGNVDRVVDALIAADKAGIKLTFDRAAAIDLAGRDVLEAVRVSVNPKVIQTPMVAAVAKDGIQLLATARVTVRANIDRLVGGAGEETIIARVGEGIVTTIGSALSHKEVLENPDRISKTVLEKGLDAGTAFEILSVDIADVDVGKNIGAQLQIDQAEADKKIAQAKAEERRAMAVAAEQENRALVEAMRAKLVEAQAQVPLALAEALREGNLGVMDYYRLKNIEADTDMRESISRAAKPEGEE

Crispr_ID: NC_017278_8

• CRISPR_ID: NC_017278_8
• CRISPR_location: 1697604-1697751
• CRISPR_type: Orphan
• Repeat_type: I-E,II-B
• Spacer_info: 2 spacers

Consensus repeat of NC_017278_8

Consensus_repeat	Method
CGTAGTCCCCACACGCGTGGGGATGGA	PILER-CR
GTAGTCCCCACACGCGTGGGGATGGA	CRISPRCasFinder

spacers of NC_017278_8

>8.1|1697631|34|NC_017278|PILER-CR
GGGTTGCCTCACTCTTGGCTGGAAGAGGAGGTCG
>8.2|1697692|34|NC_017278|PILER-CR
CCTTTGAGGACCCCACGGGGCGCGGCATACCCAC
>8.3|1697630|35|NC_017278|CRISPRCasFinder
GGGTTGCCTCACTCTTGGCTGGAAGAGGAGGTCGC
>8.4|1697691|35|NC_017278|CRISPRCasFinder
CCTTTGAGGACCCCACGGGGCGCGGCATACCCACC

CRISPR arrays and Neighbor proteins around NC_017278_8

CRISPR arrays

The CRISPR arrays of NC_017278_8

>merge|NC_017278|8|1697604-1697751|PILER-CR,CRISPRCasFinder
GTAGTCCCCACACGCGTGGGGATGGAGGGTTGCCTCACTCTTGGCTGGAAGAGGAGGTCGCGTAGTCCCCACACGCGTGGGGATGGACCTTTGAGGACCCCACGGGGCGCGGCATACCCACCGTAGTCCCCACACGCGTGGGGATGGA

>NC_017278|8|8|1697604-1697751|PILER-CR
GTAGTCCCCACACGCGTGGGGATGGAG	GGTTGCCTCACTCTTGGCTGGAAGAGGAGGTCGC
GTAGTCCCCACACGCGTGGGGATGGAC	CTTTGAGGACCCCACGGGGCGCGGCATACCCACC
GTAGTCCCCACACGCGTGGGGATGGA

>NC_017278|8|8|1697604-1697751|CRISPRCasFinder
GTAGTCCCCACACGCGTGGGGATGGA	GGGTTGCCTCACTCTTGGCTGGAAGAGGAGGTCGC
GTAGTCCCCACACGCGTGGGGATGGA	CCTTTGAGGACCCCACGGGGCGCGGCATACCCACC
GTAGTCCCCACACGCGTGGGGATGGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_017278.1|WP_014516091.1|1690573_1691161_+|KH-domain-containing-protein	unknown	unknown	gnl|CDD|224760
NC_017278.1|WP_014516094.1|1694078_1695494_+|glutamate--tRNA-ligase	unknown	unknown	gnl|CDD|234953
NC_017278.1|WP_014516092.1|1691888_1693295_-|DUF3084-domain-containing-protein	unknown	unknown	gnl|CDD|378623
NC_017278.1|WP_014516106.1|1705656_1706472_-|3-hydroxybutyryl-CoA-dehydratase	unknown	unknown	gnl|CDD|180270
NC_017278.1|WP_014516099.1|1697765_1698479_-|hypothetical-protein	unknown	unknown	unknown
NC_017278.1|WP_014516089.1|1689032_1689275_+|membrane-protein-insertion-efficiency-factor-YidD	unknown	unknown	gnl|CDD|376620
NC_017278.1|WP_041434018.1|1698489_1700577_-|AAA-family-ATPase	unknown	unknown	gnl|CDD|273429
NC_017278.1|WP_041433845.1|1691123_1691942_+|peptide-chain-release-factor-N(5)-glutamine-methyltransferase	unknown	unknown	gnl|CDD|236467
NC_017278.1|WP_014516101.1|1700638_1701532_+|phosphoglucomutase	unknown	unknown	gnl|CDD|100093
NC_017278.1|WP_014516093.1|1693295_1694024_-|LPS-export-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|213185
NC_017278.1|WP_041434017.1|1697056_1697464_+|disulfide-bond-formation-protein-B	unknown	unknown	gnl|CDD|179540
NC_017278.1|WP_014516107.1|1706475_1707183_-|purine-nucleoside-phosphorylase	unknown	unknown	gnl|CDD|350165
NC_017278.1|WP_014516090.1|1689271_1690564_+|membrane-protein-insertase-YidC	unknown	unknown	gnl|CDD|274665
NC_017278.1|WP_014516095.1|1695528_1695969_+|hypothetical-protein	unknown	unknown	unknown
NC_017278.1|WP_014516096.1|1695968_1696883_+|signal-recognition-particle-docking-protein-FtsY	unknown	unknown	gnl|CDD|236686
NC_017278.1|WP_014516104.1|1704284_1704719_+|DUF2267-domain-containing-protein	unknown	unknown	gnl|CDD|378360
NC_017278.1|WP_014516108.1|1707208_1707838_-|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|213222
NC_017278.1|WP_014516103.1|1702540_1704187_+|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl|CDD|341259
NC_017278.1|WP_014516105.1|1704715_1705588_-|phosphohydrolase	unknown	unknown	gnl|CDD|225831
NC_017278.1|WP_014516102.1|1701528_1702482_+|MBL-fold-metallo-hydrolase	unknown	unknown	gnl|CDD|293811

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_017278.1|WP_014516091.1|1690573_1691161_+|KH-domain-containing-protein	gnl|CDD|224760	COG1847, Jag, Predicted RNA-binding protein [General function prediction only].	3.97521e-41
NC_017278.1|WP_014516094.1|1694078_1695494_+|glutamate--tRNA-ligase	gnl|CDD|234953	PRK01406, gltX, glutamyl-tRNA synthetase; Reviewed.	0
NC_017278.1|WP_014516092.1|1691888_1693295_-|DUF3084-domain-containing-protein	gnl|CDD|378623	pfam11283, DUF3084, Protein of unknown function (DUF3084). This bacterial family of proteins has no known function.	3.1573e-25
NC_017278.1|WP_014516106.1|1705656_1706472_-|3-hydroxybutyryl-CoA-dehydratase	gnl|CDD|180270	PRK05809, PRK05809, short-chain-enoyl-CoA hydratase.	6.17866e-95
NC_017278.1|WP_014516105.1|1704715_1705588_-|phosphohydrolase	gnl|CDD|225831	COG3294, COG3294, HD supefamily hydrolase [General function prediction only].	1.28426e-102
NC_017278.1|WP_014516089.1|1689032_1689275_+|membrane-protein-insertion-efficiency-factor-YidD	gnl|CDD|376620	pfam01809, Haemolytic, Haemolytic domain. This domain has haemolytic activity. It is found in short (73-103 amino acid) proteins and contains three conserved cysteine residues.	2.34312e-38
NC_017278.1|WP_041434018.1|1698489_1700577_-|AAA-family-ATPase	gnl|CDD|273429	TIGR01073, ATP-dependent_DNA_helicase_PcrA, ATP-dependent DNA helicase PcrA. Designed to identify pcrA members of the uvrD/rep subfamily. [DNA metabolism, DNA replication, recombination, and repair].	0
NC_017278.1|WP_041433845.1|1691123_1691942_+|peptide-chain-release-factor-N(5)-glutamine-methyltransferase	gnl|CDD|236467	PRK09328, PRK09328, N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional.	2.33285e-89
NC_017278.1|WP_014516101.1|1700638_1701532_+|phosphoglucomutase	gnl|CDD|100093	cd05800, PGM_like2, This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Other members of this superfamily include phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four structural domains (subdomains) with a centrally located active site formed by four loops, one from each subdomain. All four subdomains are included in this alignment model.	5.97938e-62
NC_017278.1|WP_014516093.1|1693295_1694024_-|LPS-export-ABC-transporter-ATP-binding-protein	gnl|CDD|213185	cd03218, ABC_YhbG, ATP-binding cassette component of YhbG transport system. The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in cell envelope during biogenesis. YhbG is the putative ATP-binding cassette component and YhbN is the putative periplasmic-binding protein. Depletion of each gene product leads to growth arrest, irreversible cell damage and loss of viability in E. coli. The YhbG homolog (NtrA) is essential in Rhizobium meliloti, a symbiotic nitrogen-fixing bacterium.	1.65361e-141
NC_017278.1|WP_041434017.1|1697056_1697464_+|disulfide-bond-formation-protein-B	gnl|CDD|179540	PRK03113, PRK03113, putative disulfide oxidoreductase; Provisional.	2.55148e-40
NC_017278.1|WP_014516090.1|1689271_1690564_+|membrane-protein-insertase-YidC	gnl|CDD|274665	TIGR03592, yidC_oxa1_cterm, membrane protein insertase, YidC/Oxa1 family, C-terminal domain. This model describes full-length from some species, and the C-terminal region only from other species, of the YidC/Oxa1 family of proteins. This domain appears to be univeral among bacteria (although absent from Archaea). The well-characterized YidC protein from Escherichia coli and its close homologs contain a large N-terminal periplasmic domain in addition to the region modeled here. [Protein fate, Protein and peptide secretion and trafficking].	6.72294e-80
NC_017278.1|WP_014516107.1|1706475_1707183_-|purine-nucleoside-phosphorylase	gnl|CDD|350165	cd17765, PNP_ThPNP_like, purine nucleoside phosphorylases similar to Thermus thermophiles PNP. Purine nucleoside phosphorylase (PNP) catalyzes the reversible phosphorolysis of purine nucleosides. Thermus thermophiles PNP catalyzes the phosphorolysis of guanosine but not adenosine. This subfamily belongs to the nucleoside phosphorylase-I (NP-I) family, whose members accept a range of purine nucleosides as well as the pyrimidine nucleoside uridine. The NP-1 family includes phosphorolytic nucleosidases, such as purine nucleoside phosphorylase (PNPs, EC. 2.4.2.1), uridine phosphorylase (UP, EC 2.4.2.3), and 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP, EC 2.4.2.28), and hydrolytic nucleosidases, such as AMP nucleosidase (AMN, EC 3.2.2.4), and 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase (MTAN, EC 3.2.2.16). The NP-I family is distinct from nucleoside phosphorylase-II, which belongs to a different structural family.	6.50969e-119
NC_017278.1|WP_014516096.1|1695968_1696883_+|signal-recognition-particle-docking-protein-FtsY	gnl|CDD|236686	PRK10416, PRK10416, signal recognition particle-docking protein FtsY; Provisional.	7.74309e-157
NC_017278.1|WP_014516104.1|1704284_1704719_+|DUF2267-domain-containing-protein	gnl|CDD|378360	pfam10025, DUF2267, Uncharacterized conserved protein (DUF2267). This domain, found in various hypothetical bacterial proteins, has no known function.	1.19938e-39
NC_017278.1|WP_014516108.1|1707208_1707838_-|ATP-binding-cassette-domain-containing-protein	gnl|CDD|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	4.13093e-75
NC_017278.1|WP_014516103.1|1702540_1704187_+|long-chain-fatty-acid--CoA-ligase	gnl|CDD|341259	cd05936, FC-FACS_FadD_like, Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD. This subfamily of the AMP-forming adenylation family contains Escherichia coli FadD and similar prokaryotic fatty acid CoA synthetases. FadD was characterized as a long-chain fatty acid CoA synthetase. The gene fadD is regulated by the fatty acid regulatory protein FadR. Fatty acid CoA synthetase catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.	0
NC_017278.1|WP_014516102.1|1701528_1702482_+|MBL-fold-metallo-hydrolase	gnl|CDD|293811	cd07725, TTHA1429-like_MBL-fold, uncharacterized Thermus thermophilus TTHA1429 and related proteins; MBL-fold metallo hydrolase domain. Includes the MBL-fold metallo hydrolase domain of uncharacterized Thermus thermophilus TTHA1429 and related proteins. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	3.13148e-64

Protein sequences

>NC_017278.1|WP_041434017.1|1697056_1697464_+|disulfide-bond-formation-protein-B
MKRGPLLLTFAWMVALVATLGSLYYSEVRLFLPCELCWYQRIFMYPQAILLGLALWRQDLSVWPYALALSLIGGGISTLHLLEQKFPELFTLACKPPVPCSVEYMPQFPIPLQALIAFVLIAVSMALLAKEARGR
>NC_017278.1|WP_014516096.1|1695968_1696883_+|signal-recognition-particle-docking-protein-FtsY
MGFLDRLKAGLAKTREKLLGAIPWGANPEEVLEELEMALLAADVGLAATEELLAQVRASGRKDLKEAVKEKLVAMLEPDPRRATLRKLGFRPQNPKPVEPQGHVVMVVGVNGVGKTTTIAKLGRHYQELGKKVMFCAGDTFRAAGGMQLAEWGKRLGIPVLQGAEGADPAGLAFDAAQARKARGYDLLFVDTAGRLHTKHNLMEELKKVKRAIGKADPGEPGEVWLVLDAVTGQNGLEQAKRFHEAVGLTGVIVTKLDGTAKGGVLVPIVRTLGVPIRFIGVGEGPEDLQPFDAEAFVEALLEA
>NC_017278.1|WP_014516095.1|1695528_1695969_+|hypothetical-protein
MKRLLLLLTLLLGVASAQSAIQMRFGYGETLGLTFGAGVENRLRQNLVGRLSAEIAPAAPGVALEGALLFKPDLGQYEPSLSGLLPYFGGGVGAVVGPRPTAGVSFTLGLEGLLDPYTGLLAESTYVYGFADFPKVWRFTLGVNFR
>NC_017278.1|WP_014516094.1|1694078_1695494_+|glutamate--tRNA-ligase
MVVTRIAPSPTGDPHVGTAYIALFNYVWARKNGGRFLVRIEDTDRARYVPGAEERILAALRWLGIPYDEGPDIGGPHGPYRQSERLPLYRQYAEELLRRGWAYRAFETPEELERIRQEKGGYDGRARHIPPEEAEARARRGEPHVIRLKVPRPGTTEVRDELRGVVVYDNGEIPDVVLLKSDGYPTYHLANVVDDHLMGVTDVIRAEEWLVSTPIHVLLYRAFGWETPKFYHMPLLRNPDKTKISKRKSHTSLEWYKAEGFLPEALRNYLALMGFSMPDGREIFSLEELIAAFTWERVSLGGPVFDLDKLRWLNGKYIREVLSLEEVAERVKPFLEERGLSWPDEAYLRRAVELMRPRFDTLKELPEKAPYLFQEDYPVTEKAREKLREGLDLLKEVQPLLEAQEAWSEAALDTLLRGFAQAKGLKLGQVAQPLRAALTGTLETPGLFEIMTLLGKARTLARLERALGKGA
>NC_017278.1|WP_014516093.1|1693295_1694024_-|LPS-export-ABC-transporter-ATP-binding-protein
MDGELLAQGLRKRYGPKEVVKGVDLHLKRGEIVALFGPNGAGKTTTFYMVVGFIRPTGGRIFLKGQEVSRLPMYRRARLGLGYLPQEPSAFRRMTVLENLLAVLEFQPLAPKERLEKAKALLEELAIYHLRDRMAYALSGGERRRLEMARALATDPDFILLDEPFTGVDPKNVREIQKVIAELRERRGVGVFITDHAVRETLAITDRVYVMYDGEILFHGDPETFARDQGVRRHYLGEDYEL
>NC_017278.1|WP_014516092.1|1691888_1693295_-|DUF3084-domain-containing-protein
MTFWALLTLILLLSALVAYLGDKVAKWAGKRHYRLFGLRPRQTATLIAVATGVGIALLSYLGFLLVFREAREVILEAEAVRQERDRLRSEREVLLKAKEAMEGETARALAELNALRAERKRLYEALEGAEALRKRLEAEAQALEGQVAALQGERRALLRERERLLEGQEALSQLLAEKNRELGHRTRELAGLEARVRALQGEAKRLEGEKERLLRESQRLEGDLALLQAQLEEARRQRQALAQEVVSLKEALLRSRQELRQTEERVRSLLAQAEALQGERGQLAQNLARLAQGFYLGEVRLGQEEGQALLQQVAERRALLQGFRGAELLGGATGPGLAVLEGAGYREGRLLVRVRFYPERKAFAQGEVLAARTFRLSTPARHQEALEALGQEVRGRLLEAGFPPEYATFPSAEELARGLALLQGRKGVVRVGVVAAKDLWTAERPLLYYTLLGGPPGPEVPIPTRQVP
>NC_017278.1|WP_041433845.1|1691123_1691942_+|peptide-chain-release-factor-N(5)-glutamine-methyltransferase
MTRLLREAQARLKAAGLPEGEAWDLLALASGLSRRDLLLGLDKPPPPGTEARLEGLLGRRLSGYPLQYLLGEVEFFGLPLRVEEGVLIPRPETEGLVELALALPLPPTPRILDVGTGTGAIALALKAHLPQAEVYATEVDERALALARENARRLGLEVDFLHAPLTAGMEGLDLLVSNPPYLPEAYRRVAPPELAYENPLALYAGEEGLAVARPLALEGERALRPGGFLLLELAPENVHLLAQELRERGWEEVAVLRDLAGRDRYLRARRPA
>NC_017278.1|WP_014516091.1|1690573_1691161_+|KH-domain-containing-protein
MDEKKKNIDDLLSDLGVLEEAPVEVELKEAGREARQKTPKEVLEEFLVGLLLRLDPAHYVEVRQEGNLLRAEVKGGDLGRFIGKEGRTLKAAEYLAGVVLAKHFGGAYRVVLDAAGYRKRQEERIRKLAEEAALTVAMTREPLHLPPMRPSERRIVHMLLKNHPQVTTESQGEGEERHVVVYPRDAASPGSPGPA
>NC_017278.1|WP_014516090.1|1689271_1690564_+|membrane-protein-insertase-YidC
MKRLWALLLLLVPALALEAGFKDQDVNGDGTPEKVAVTNLMDLAFNGEGQIVGWYVKTYKGTAFGDYTRAPNLSGNGPVVATEGFRPERAEFLVEDGRLLARFQGKEGSLTYRIERGRYTVSVEASFPLSLKLSAQGTPKVLLEGQKEALPSGEGRVRYLAWQTRPKAGYALVAFAEEALSGKLVGKEGTLQLAPGKPLRLYGGQNELVRFHVEGLLGLPGLFAPNIWGQLSLGLLWLMETAFRYTGSWGLAILFLTLVVRLLLWPLMHQQFKSMAELQRLQPLIQKINEKYKDDPNKRAEATMKLYQEHKVNPAAGCLPLLIQMPILFILWKVIANYEFGQGLLWIPDLALPDPFYVLPALYVASTFLSTWLSAHGNKDLIRQSLFMNLIFIFLVLQFPSGVTLYWVLSNLIGLVQQWLINRSLKPLAA
>NC_017278.1|WP_014516089.1|1689032_1689275_+|membrane-protein-insertion-efficiency-factor-YidD
MRRLLILLVQAYRRFLSPLKPKTCRFHPTCSAYALEALERHGALWGSYLAARRILKCHPLHPGGLDPVPSVFPPRKEGAR
>NC_017278.1|WP_014516099.1|1697765_1698479_-|hypothetical-protein
MWPPYHQPRPLVFFYKKPSPLFDRLVAEVTTAKLPLFPYPVETENPWAALPCLWPLGFAGAVLAEALPPPEGVRLEAEAQAAGLMDLAVPGAKGLWGQYTEGVALERFLGQHFPGAKALWLGPLRPALAPFLRPLAQVAVAASTFAEGDSFLARLPERARGPVVARAEEVQALALRADLLLYAGGRLSLEHLQPFHVLVALVPPDRGVWERVQAVYAPEDLLGVRVRVILEGLGYPV
>NC_017278.1|WP_041434018.1|1698489_1700577_-|AAA-family-ATPase
MDEAWLSSLNEAQRQAVLHFEGPALVVAGAGSGKTRTVVHRVAYLMARRGVYPSEILAVTFTNKAAEEMRERLKAMVKGAGELWVSTFHAAALRILRFYGERVGLKPGFVVYDEDDQTALLKEVLKELGVSAKPGPIKALLDRAKNRGEPPERLLADLPEYYAGLSRGRLLDVLHRYQQALWAQGALDFGDILLLALKLLEEDPEVRKRVRKRARFIHVDEYQDTSPVQYRLTKLLAGEEANLMAVGDPDQGIYSFRAADIKNILQFTEDFPGAKVYRLEENYRSTERILRFANAVIVKNALRLEKTLRPVKSGGEPVRLFRARDAREEARFVAEEVLRLGPPYDRVAVLYRTNAQSRLLEQALASRGIGARVVGGVGFFERAEVKDLLAYARLALNPLDAVSLKRVLNTPPRGIGPATVEKVQAIAQEKGLPLYEALKVAAQVLPRPEPLRHFLALMEELMDLAFGPAEAFFRHLLEATDYPAYLKEAYPEDLEDRLENVEELLRAAREAEGLMDFLDKVALTARAEEPGEAGGKVALMTLHNAKGLEFPVVFLVGVEEGLLPHRSSVSTLEGLEEERRLFYVGVTRAQERLYLSYAEEREVYGRPEASRPSRFLEEVEEGLYEEYDPYRLPPPKPVPPPHRAKPGAFRGGEKVVHPRFGLGTVVAASGDEVTVHFDGVGLKRLSLKYADLRPA
>NC_017278.1|WP_014516101.1|1700638_1701532_+|phosphoglucomutase
MELSPTQDGFLGEIAKDFTFATVARLAGGVAARLAEEGLRRVVVAHDTRFLAKEMAEEAARVLAGAGLETHLLQGPAPFPLFAFALAEKEAAGFYLTASRKPAPYQGVKLRRGPGKPLSPEELSLPPSPPEGRGSFALLDLKKPYLERLAQSAGEMGEKGGVVYLDAMGGAGGGFLAGAFKRLGLGAELREIHPLPHPLFYGVDPNPVPENLNTLRVLLKALEPPGVGFALDGDADRLAVFLPGGEMLPSEGVLAHLREASAGREVQGDGEGGYLFPWHLPEKDAFLAALLLLKVLL
>NC_017278.1|WP_014516102.1|1701528_1702482_+|MBL-fold-metallo-hydrolase
MRELLPGLYLLPVPIPYPLKTVNLYLLKGEGEVALVDTALGTKTARGTLELYLAELGLCFQDVRTVLLTHHHPDHYGLAGFLEGLGAKVYLHEEELGRGHRFWQEPEAFEGASWQLFLEHGTPEEALGGIRETMAKTRERVHPPKNPVPLREGEVLEVAGKRLRVVWTPGHADGHVAFWLEEEGVLLAGDALLERVSPNVGLWAYTRENPLRDFLASLERLAGLPAQVAYAGHFGPIPQVGKRAQELALHHQERLEALLRHLEGPETAWELSLKLFPQELDAAGRRFAFAETLAHLEYLRHEGQVGREGPPYRYFRA
>NC_017278.1|WP_014516103.1|1702540_1704187_+|long-chain-fatty-acid--CoA-ligase
MHPWYAHYDPGVPQEAPKPWLLTELLRENARRYPEKVALEFLGRSISYQRLWRQVEAFARGLQEAGLEPGERVAIMLPNSPQFVIAFFGTLLAGGVAVNTNPMYTPRELRHQLLDSGAKALVILDLLLPRYQEVKAEAPVEVLVRTGIQDYLPFPKNLLYPLTLKRKGQWPKELEGIPWRAFLKAWKPEPVALDLDDLALLQYTGGTTGVAKGAMLTHRNLSTNALQVRAWIPDFREGEEVVLGAIPFFHVYGMTVAMNLALLGAAKLVLLPRPEIKPIVEAIEKHGVTLFPGVPTLYVAFNNFPGIEGRSLKSIRACISGSAPLPLEVAERFEKLTGAKLVEGYGLTEASPVTHCNPLYGPRKLGSVGLPFPGVEAKVVDEEGKELPPGEVGELILKGPNVMKGYWNRPEESQKTLKDGWLFTGDLAKMDPDGYFYIVDRKKDMIIAGGYNIYPREVEEVLYQHPAVQEAAVVGVPDPYRGETVAAFIVLKDEYKGKVSEKDIETFCRQNLAAYKVPRILQFRDTLPKSSVGKILKRELAKEVPRRA
>NC_017278.1|WP_014516104.1|1704284_1704719_+|DUF2267-domain-containing-protein
MSATGLEVFDTTLHKTHAWLKAIMEALGLEDRHRAYMALRAVLHALRDRLPVEEVAQLGAELPMLVRGLYYEGWDPTGKPLKERHKEEFLAHVARELRTPSGPALDPEAAARAVFQVLAQKVSEGEIRDVQNLLPKELRELWPR
>NC_017278.1|WP_014516105.1|1704715_1705588_-|phosphohydrolase
MTGERVVHVASPKAKLYAEADQAIRERLRAFPKALRAYELLIQDPEARAGWNMANYLTMRKLGYNDHGRVHALLTGAASVAILGLLAEAGVRLDTLESGAGELEDAYVVVLLSTMLHDLGNQVHREHHEAFGVTLALPILNRILEKIYPDPEQRTALRALILHGIHSHDLNPEPLTVEAGVTAVADGTDITKGRGRKAFALGSIDIHSISALAVDEVRILKGEKVPVEIQVTMNNSAGIFQVEETLTKKVLRSPLRPYVTVVAMTGEGGQDQRIVHRVRLHETEDRFVLD
>NC_017278.1|WP_014516106.1|1705656_1706472_-|3-hydroxybutyryl-CoA-dehydratase
MAHEHEHEFILEIPEFEHLAYEVEGGIALVTLKRPEALNALSQDLLQELAEVTEVIHQDPEARVVIFTGEGKAFAAGADLKEIAALKDPFMAREYALLGQQVFAEIAALPVPTIAAIHGYALGGGLELALACDLRVASKEAKLGLPEVGLGLIPGFGGTQRLPRLIGRGRALDLIFTGRHVPAEEALALGLVNQVGEDALEEAKKLAQKILKNAPIALALAKESVVRGEGLDLAEALEIEADLFGYASATEDMKEGVRAFLEKRPPNFKGE
>NC_017278.1|WP_014516107.1|1706475_1707183_-|purine-nucleoside-phosphorylase
MSPIHVRGQPGEVAERVLLPGDPGRAEWIAKTFLEDPVQYTSYRGLLGYTGRYRGVRVSVQTTGMGAPSASIVAEELVSLGARVLLRVGTCGAVDGALAPGDLVVAQGAVPLDGATRQYLEGRPYAPLPDPELFRALWDQARKKGYPHHVGLVATEDAFYATTPEGAKAWARYGVLAFEMEASALFLIGKLRGVKAGALLTVSNRIGDPELAPPEVLAEGVRRMVEVALEALLEV
>NC_017278.1|WP_014516108.1|1707208_1707838_-|ATP-binding-cassette-domain-containing-protein
MRPVLQVEDLGFAYGNGFLFRHLSFRLAPGEALAVLGPSGSGKTTLLHLLAGLLPLQEGEVYWEGEPLRGLSQGALARRRLSFLGLVFQHHFLFPELTALENVLAPGYLAGRVDRGWALALLGRLGLGGRAHFLPQRLSGGERQRVAVARALYLRPRLLLADEPTASLDRRQAREVLRLLQELAQEVGAALVLATHDEALVEGFPALKL

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_017278_4	4.21|269418|36|NC_017278|CRT,PILER-CR,CRISPRCasFinder	269418-269453	36	NZ_LR027519	Thermus thermophilus isolate TTHNAR1 plasmid 3, complete sequence	8230-8265	2	0.944
NC_017278_4	4.21|269418|36|NC_017278|CRT,PILER-CR,CRISPRCasFinder	269418-269453	36	NC_017590	Thermus thermophilus JL-18 plasmid pTTJL1802, complete sequence	110993-111028	2	0.944
NC_017278_4	4.21|269418|36|NC_017278|CRT,PILER-CR,CRISPRCasFinder	269418-269453	36	NC_017767	Thermus thermophilus HB8 plasmid pVV8, complete sequence	2229-2264	3	0.917
NC_017278_1	1.2|88068|31|NC_017278|PILER-CR,CRT	88068-88098	31	MN855895	Bacteriophage sp. isolate 385, complete genome	2000-2030	9	0.71
NC_017278_7	7.2|1414763|33|NC_017278|CRISPRCasFinder,CRT,PILER-CR	1414763-1414795	33	MN732867	Erwinia phage Hena1, complete genome	101013-101045	9	0.727
NC_017278_8	8.2|1697692|34|NC_017278|PILER-CR	1697692-1697725	34	NZ_CP017750	Cupriavidus sp. USMAA2-4 plasmid unnamed1, complete sequence	506284-506317	9	0.735
NC_017278_8	8.2|1697692|34|NC_017278|PILER-CR	1697692-1697725	34	NZ_CP032520	Cupriavidus oxalaticus strain T2 plasmid unnamed1, complete sequence	31152-31185	9	0.735
NC_017278_8	8.2|1697692|34|NC_017278|PILER-CR	1697692-1697725	34	NZ_CP043441	Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence	260712-260745	9	0.735
NC_017278_1	1.5|88067|32|NC_017278|CRISPRCasFinder	88067-88098	32	MN855895	Bacteriophage sp. isolate 385, complete genome	1999-2030	10	0.688
NC_017278_2	2.7|256526|35|NC_017278|PILER-CR,CRISPRCasFinder,CRT	256526-256560	35	NZ_CP011274	Planctomyces sp. SH-PL62 plasmid pPL62-1, complete sequence	69261-69295	10	0.714
NC_017278_2	2.13|256924|39|NC_017278|PILER-CR,CRISPRCasFinder,CRT	256924-256962	39	NZ_CP006990	Rhizobium sp. IE4771 plasmid pRetIE4771d, complete sequence	373470-373508	10	0.744
NC_017278_2	2.13|256924|39|NC_017278|PILER-CR,CRISPRCasFinder,CRT	256924-256962	39	NZ_CP020911	Rhizobium etli strain NXC12 plasmid pRetNXC12e, complete sequence	519527-519565	10	0.744
NC_017278_2	2.13|256924|39|NC_017278|PILER-CR,CRISPRCasFinder,CRT	256924-256962	39	NZ_CP054028	Rhizobium sp. JKLM19E plasmid pPR19E01, complete sequence	641431-641469	10	0.744
NC_017278_2	2.13|256924|39|NC_017278|PILER-CR,CRISPRCasFinder,CRT	256924-256962	39	CP007644	Rhizobium etli bv. phaseoli str. IE4803 plasmid pRetIE4803c, complete sequence	372930-372968	10	0.744
NC_017278_8	8.2|1697692|34|NC_017278|PILER-CR	1697692-1697725	34	NZ_CP020444	Paracoccus yeei strain FDAARGOS_252 plasmid unnamed4, complete sequence	92340-92373	11	0.676
NC_017278_8	8.2|1697692|34|NC_017278|PILER-CR	1697692-1697725	34	NZ_CP020444	Paracoccus yeei strain FDAARGOS_252 plasmid unnamed4, complete sequence	135789-135822	11	0.676
NC_017278_8	8.2|1697692|34|NC_017278|PILER-CR	1697692-1697725	34	NZ_CP020444	Paracoccus yeei strain FDAARGOS_252 plasmid unnamed4, complete sequence	146862-146895	11	0.676
NC_017278_8	8.4|1697691|35|NC_017278|CRISPRCasFinder	1697691-1697725	35	NZ_CP020444	Paracoccus yeei strain FDAARGOS_252 plasmid unnamed4, complete sequence	92340-92374	12	0.657
NC_017278_8	8.4|1697691|35|NC_017278|CRISPRCasFinder	1697691-1697725	35	NZ_CP020444	Paracoccus yeei strain FDAARGOS_252 plasmid unnamed4, complete sequence	135789-135823	12	0.657
NC_017278_8	8.4|1697691|35|NC_017278|CRISPRCasFinder	1697691-1697725	35	NZ_CP020444	Paracoccus yeei strain FDAARGOS_252 plasmid unnamed4, complete sequence	146862-146896	12	0.657

1. spacer 4.21|269418|36|NC_017278|CRT,PILER-CR,CRISPRCasFinder matches to NZ_LR027519 (Thermus thermophilus isolate TTHNAR1 plasmid 3, complete sequence) position: , mismatch: 2, identity: 0.944

ctgggggtgcggggaagacctccctggcccgggacc	CRISPR spacer
ccgggggggcggggaagacctccctggcccgggacc	Protospacer
*.***** ****************************

2. spacer 4.21|269418|36|NC_017278|CRT,PILER-CR,CRISPRCasFinder matches to NC_017590 (Thermus thermophilus JL-18 plasmid pTTJL1802, complete sequence) position: , mismatch: 2, identity: 0.944

ctgggggtgcggggaagacctccctggcccgggacc	CRISPR spacer
ccgggggggcggggaagacctccctggcccgggacc	Protospacer
*.***** ****************************

3. spacer 4.21|269418|36|NC_017278|CRT,PILER-CR,CRISPRCasFinder matches to NC_017767 (Thermus thermophilus HB8 plasmid pVV8, complete sequence) position: , mismatch: 3, identity: 0.917

ctgggggtgcggggaagacctccctggcccgggacc	CRISPR spacer
ccggaggcgcggggaagacctccctggcccgggacc	Protospacer
*.**.**.****************************

4. spacer 1.2|88068|31|NC_017278|PILER-CR,CRT matches to MN855895 (Bacteriophage sp. isolate 385, complete genome) position: , mismatch: 9, identity: 0.71

gcatctttcgcgaacatgggcggcgcccccc------	CRISPR spacer
gcatcttccgcgaacgtgggcgg------gcagaaga	Protospacer
*******.*******.*******       *      

5. spacer 7.2|1414763|33|NC_017278|CRISPRCasFinder,CRT,PILER-CR matches to MN732867 (Erwinia phage Hena1, complete genome) position: , mismatch: 9, identity: 0.727

ccatgaagaaactcaacttggcggccatcgtgt	CRISPR spacer
ccatgaagaaattcaatttggcggggcaccctt	Protospacer
***********.****.*******    * . *

6. spacer 8.2|1697692|34|NC_017278|PILER-CR matches to NZ_CP017750 (Cupriavidus sp. USMAA2-4 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.735

cctttgaggaccccacggggcgcggcatacccac	CRISPR spacer
ccgagccagtccccactggacgcggcatacccac	Protospacer
**     .* ****** **.**************

7. spacer 8.2|1697692|34|NC_017278|PILER-CR matches to NZ_CP032520 (Cupriavidus oxalaticus strain T2 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.735

cctttgaggaccccacggggcgcggcatacccac	CRISPR spacer
ccgagccagtccccactggacgcggcatacccac	Protospacer
**     .* ****** **.**************

8. spacer 8.2|1697692|34|NC_017278|PILER-CR matches to NZ_CP043441 (Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.735

cctttgaggaccccacggggcgcggcatacccac	CRISPR spacer
ccgagccagtccccactggacgcggcatacccac	Protospacer
**     .* ****** **.**************

9. spacer 1.5|88067|32|NC_017278|CRISPRCasFinder matches to MN855895 (Bacteriophage sp. isolate 385, complete genome) position: , mismatch: 10, identity: 0.688

ggcatctttcgcgaacatgggcggcgcccccc------	CRISPR spacer
cgcatcttccgcgaacgtgggcgg------gcagaaga	Protospacer
 *******.*******.*******       *      

10. spacer 2.7|256526|35|NC_017278|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP011274 (Planctomyces sp. SH-PL62 plasmid pPL62-1, complete sequence) position: , mismatch: 10, identity: 0.714

aaggcccccaaggccaaggcggc-------cccgggggaggt	CRISPR spacer
gaggcccccaaggccgaggcggcgcccgctcccag-------	Protospacer
.**************.*******       ***.*       

11. spacer 2.13|256924|39|NC_017278|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP006990 (Rhizobium sp. IE4771 plasmid pRetIE4771d, complete sequence) position: , mismatch: 10, identity: 0.744

gggggcggccaaggccgaggccgaggcccccaaggcggt	CRISPR spacer
gggcgcgggcaaggccgaggccgaggccggacgcgccgg	Protospacer
*** **** *******************    . ** * 

12. spacer 2.13|256924|39|NC_017278|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP020911 (Rhizobium etli strain NXC12 plasmid pRetNXC12e, complete sequence) position: , mismatch: 10, identity: 0.744

gggggcggccaaggccgaggccgaggcccccaaggcggt	CRISPR spacer
gggcgcgggcaaggccgaggccgaggccggacgcgccgg	Protospacer
*** **** *******************    . ** * 

13. spacer 2.13|256924|39|NC_017278|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP054028 (Rhizobium sp. JKLM19E plasmid pPR19E01, complete sequence) position: , mismatch: 10, identity: 0.744

gggggcggccaaggccgaggccgaggcccccaaggcggt----	CRISPR spacer
gggcgcgggcaaggccgaggccgaggcc----ggacgcccctg	Protospacer
*** **** *******************    .*.** .    

14. spacer 2.13|256924|39|NC_017278|PILER-CR,CRISPRCasFinder,CRT matches to CP007644 (Rhizobium etli bv. phaseoli str. IE4803 plasmid pRetIE4803c, complete sequence) position: , mismatch: 10, identity: 0.744

gggggcggccaaggccgaggccgaggcccccaaggcggt	CRISPR spacer
gggcgcgggcaaggccgaggccgaggccggacgcgccgg	Protospacer
*** **** *******************    . ** * 

15. spacer 8.2|1697692|34|NC_017278|PILER-CR matches to NZ_CP020444 (Paracoccus yeei strain FDAARGOS_252 plasmid unnamed4, complete sequence) position: , mismatch: 11, identity: 0.676

cctttgaggaccccacggggcgcggcatacccac	CRISPR spacer
cctttgaggtccccacgggacgcggttccggtga	Protospacer
********* *********.*****. .   .. 

16. spacer 8.2|1697692|34|NC_017278|PILER-CR matches to NZ_CP020444 (Paracoccus yeei strain FDAARGOS_252 plasmid unnamed4, complete sequence) position: , mismatch: 11, identity: 0.676

cctttgaggaccccacggggcgcggcatacccac	CRISPR spacer
cctttgaggtccccacgggacgcggttccggtga	Protospacer
********* *********.*****. .   .. 

17. spacer 8.2|1697692|34|NC_017278|PILER-CR matches to NZ_CP020444 (Paracoccus yeei strain FDAARGOS_252 plasmid unnamed4, complete sequence) position: , mismatch: 11, identity: 0.676

cctttgaggaccccacggggcgcggcatacccac	CRISPR spacer
cctttgaggtccccacgggacgcggttccggtga	Protospacer
********* *********.*****. .   .. 

18. spacer 8.4|1697691|35|NC_017278|CRISPRCasFinder matches to NZ_CP020444 (Paracoccus yeei strain FDAARGOS_252 plasmid unnamed4, complete sequence) position: , mismatch: 12, identity: 0.657

cctttgaggaccccacggggcgcggcatacccacc	CRISPR spacer
cctttgaggtccccacgggacgcggttccggtgat	Protospacer
********* *********.*****. .   .. .

19. spacer 8.4|1697691|35|NC_017278|CRISPRCasFinder matches to NZ_CP020444 (Paracoccus yeei strain FDAARGOS_252 plasmid unnamed4, complete sequence) position: , mismatch: 12, identity: 0.657

cctttgaggaccccacggggcgcggcatacccacc	CRISPR spacer
cctttgaggtccccacgggacgcggttccggtgat	Protospacer
********* *********.*****. .   .. .

20. spacer 8.4|1697691|35|NC_017278|CRISPRCasFinder matches to NZ_CP020444 (Paracoccus yeei strain FDAARGOS_252 plasmid unnamed4, complete sequence) position: , mismatch: 12, identity: 0.657

cctttgaggaccccacggggcgcggcatacccacc	CRISPR spacer
cctttgaggtccccacgggacgcggttccggtgat	Protospacer
********* *********.*****. .   .. .

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	1694078 : 1759605	51	Bacillus_phage(40.0%)	integrase,tRNA,transposase	attL 1730515:1730560|attR 1759675:1759720
DBSCAN-SWA_2	2234169 : 2241253	9	Streptococcus_phage(16.67%)	NA	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>NC_017278|1694078:1759605|DBSCAN-SWA
TATGGTGGTGACCCGCATCGCCCCAAGCCCTACGGGGGACCCCCACGTGGGCACGGCCTATATCGCCCTTTTCAACTACGTCTGGGCCCGGAAAAACGGGGGCAGGTTCCTGGTGCGCATTGAGGATACGGACCGGGCTCGGTATGTGCCCGGGGCCGAGGAAAGGATCCTGGCGGCCCTCAGGTGGCTCGGCATCCCCTACGACGAGGGGCCGGATATCGGCGGGCCCCACGGCCCTTACCGGCAATCCGAGCGGCTTCCCCTGTACCGGCAATACGCCGAGGAACTCCTGCGGCGGGGCTGGGCCTACCGGGCCTTTGAAACCCCGGAGGAGCTGGAGCGGATCCGCCAGGAAAAGGGAGGCTACGATGGCCGGGCCCGCCACATTCCCCCGGAAGAGGCCGAGGCCCGGGCCAGGCGGGGGGAGCCCCACGTGATCCGCCTCAAGGTGCCCCGCCCCGGAACCACGGAGGTGCGGGACGAGCTCCGGGGAGTGGTGGTCTACGATAACGGGGAGATCCCCGACGTGGTCCTCCTCAAGTCGGACGGCTACCCCACCTACCACCTGGCCAACGTGGTGGACGACCACCTCATGGGGGTGACGGACGTGATCCGGGCGGAGGAGTGGCTGGTCTCCACCCCCATCCACGTCCTCCTCTACCGGGCCTTTGGCTGGGAAACCCCCAAGTTCTACCACATGCCCCTCCTGCGCAACCCCGACAAGACCAAGATCTCCAAGCGGAAAAGCCACACCTCCTTGGAGTGGTACAAGGCGGAGGGCTTCCTGCCCGAGGCCCTGCGCAACTACCTGGCCCTCATGGGCTTTTCCATGCCGGATGGGCGGGAGATCTTCTCCCTCGAGGAGCTCATCGCCGCCTTCACCTGGGAACGGGTCTCCCTGGGGGGGCCGGTCTTTGACCTGGACAAGCTGCGCTGGCTGAACGGGAAGTACATCCGCGAGGTCCTATCCCTGGAGGAGGTGGCGGAAAGGGTGAAGCCCTTCCTGGAGGAAAGGGGCCTTTCCTGGCCGGACGAGGCCTACCTGAGGCGGGCGGTGGAGCTCATGCGCCCCCGGTTTGACACCCTAAAAGAGCTTCCAGAAAAAGCCCCTTACCTCTTCCAGGAGGACTACCCTGTGACCGAAAAGGCCAGGGAAAAGCTCAGGGAGGGCCTGGATCTTCTGAAGGAGGTCCAACCCCTCCTGGAAGCCCAGGAGGCGTGGAGCGAGGCGGCCTTGGATACCCTCCTGCGGGGCTTCGCCCAAGCCAAGGGCCTGAAGCTGGGCCAGGTGGCCCAGCCCCTGCGGGCGGCCCTCACCGGCACCCTGGAAACCCCGGGGCTCTTTGAGATCATGACCCTCCTGGGCAAGGCCCGCACCCTGGCCCGGCTGGAGCGGGCCCTGGGGAAAGGCGCTTAGGGAAATCTCACGCAAGGGCGCTAGACTCGGGAGCGTGAAACGGCTTCTTCTCCTCCTCACCTTGCTACTGGGCGTGGCCAGCGCCCAAAGTGCCATTCAGATGCGCTTTGGCTACGGCGAAACCCTGGGCCTCACCTTTGGGGCCGGGGTAGAAAACCGCCTGCGGCAGAACCTGGTGGGCCGGCTGAGCGCGGAGATCGCCCCTGCCGCCCCCGGGGTGGCCCTGGAAGGGGCCCTCCTCTTTAAGCCCGACCTGGGCCAGTACGAGCCCAGCCTCTCGGGCCTTCTCCCCTACTTCGGCGGAGGCGTGGGGGCGGTGGTGGGGCCTAGGCCCACCGCTGGGGTAAGCTTCACCCTGGGCCTCGAGGGCCTCCTGGACCCCTACACTGGCCTTTTGGCCGAAAGCACCTACGTCTACGGCTTCGCCGACTTCCCCAAGGTCTGGCGCTTCACCCTCGGGGTAAACTTCCGCTGATGGGCTTCTTGGACCGCCTGAAGGCGGGGCTGGCCAAAACGCGGGAAAAACTCCTCGGGGCCATCCCCTGGGGCGCCAACCCCGAGGAGGTGCTGGAGGAGCTGGAGATGGCCCTCCTGGCCGCCGACGTGGGCCTGGCCGCCACCGAGGAGCTCCTTGCCCAAGTGCGGGCTTCGGGGCGCAAGGACCTCAAGGAGGCGGTGAAGGAAAAGCTGGTGGCCATGCTGGAGCCCGACCCGCGCCGGGCCACGCTGCGCAAGCTGGGCTTCCGCCCGCAAAACCCCAAGCCCGTGGAGCCCCAGGGGCACGTGGTCATGGTGGTGGGGGTCAACGGGGTGGGCAAGACCACCACCATCGCCAAGCTGGGCCGCCATTACCAGGAGCTGGGCAAAAAGGTGATGTTCTGCGCCGGGGACACCTTCCGCGCCGCCGGGGGCATGCAGCTTGCGGAGTGGGGCAAGCGCCTGGGCATCCCCGTCCTCCAGGGCGCGGAAGGGGCAGACCCCGCGGGTCTAGCCTTTGACGCCGCCCAGGCCCGCAAGGCGCGAGGGTACGACCTCCTTTTCGTGGACACCGCAGGCCGCCTGCACACCAAGCACAACCTCATGGAGGAGCTGAAAAAGGTCAAACGGGCCATCGGCAAAGCCGACCCTGGGGAACCTGGGGAGGTCTGGCTGGTGCTGGATGCGGTCACGGGGCAAAACGGCCTCGAGCAAGCCAAGAGGTTCCACGAGGCTGTGGGCCTTACCGGGGTAATCGTGACCAAGCTGGACGGCACCGCCAAGGGAGGGGTGTTGGTGCCCATCGTGCGCACCCTAGGGGTGCCCATCCGCTTCATCGGGGTAGGGGAAGGCCCGGAAGACCTGCAACCCTTTGACGCCGAGGCCTTTGTAGAGGCCCTTCTGGAAGCCTAATCCTCTTCTTTTTGCTCCCGCCAGGGACAGTGGCGGCACCCCGAGCCGCAACAGTAGCCCCGCTTGCGGTGGTAGGCCTCGGTGAAGACCACCCTCCCTTCCTCCCTGTAATAGTCCTCTCCTTCCTTCAGCTCTTCCTTCACAAGCTACAGTTTAGGGGTATGCTGGGGCCGATGAAGCGCGGCCCCCTCCTCCTCACCTTCGCTTGGATGGTGGCCCTGGTGGCCACCTTGGGAAGCCTGTACTACTCCGAGGTGCGCCTTTTCCTGCCCTGCGAGCTCTGCTGGTACCAGCGCATCTTCATGTATCCGCAGGCCATTTTGCTGGGCCTAGCCCTCTGGCGGCAGGACCTCAGCGTCTGGCCTTACGCCCTGGCCCTTTCCCTCATCGGGGGGGGCATCAGCACCCTCCACCTCCTGGAGCAGAAGTTTCCTGAGCTTTTCACCCTGGCCTGCAAACCGCCCGTGCCCTGCTCCGTGGAGTACATGCCCCAGTTTCCCATCCCCCTCCAGGCCCTTATCGCCTTCGTGCTGATTGCGGTCAGCATGGCCCTGCTGGCGAAAGAAGCGCGGGGGCGGTAAGGTGCTATGCTAGGGCTAGCGCCAGACTGTTTTGCTTCTCCCTCGAGGCGCGGGGGCATCTTGACAAGGTTTCCCGGAGTGCTTCCCTAAAAAGGACATAAAGGGGGGTGAGCTGGGATTTTTGCCGTCTGGGTCATGTGTAGTCCCCACACGCGTGGGGATGGAGGGTTGCCTCACTCTTGGCTGGAAGAGGAGGTCGCGTAGTCCCCACACGCGTGGGGATGGACCTTTGAGGACCCCACGGGGCGCGGCATACCCACCGTAGTCCCCACACGCGTGGGGATGGACCGGCACCCTTTGGCTAAACCGGATACCCTAGCCCCTCGAGGATCACCCGCACCCGCACGCCCAGAAGGTCCTCGGGGGCGTAGACCGCTTGCACCCGCTCCCATACCCCTCGGTCCGGGGGAACCAAGGCCACAAGGACGTGAAAGGGCTGCAGATGCTCTAGGGAAAGCCGGCCCCCGGCGTATAAGAGCAGATCCGCCCGCAAGGCCAGGGCCTGGACCTCCTCGGCGCGGGCCACCACCGGCCCCCTGGCCCGCTCGGGCAGGCGGGCCAGGAAGCTATCCCCCTCGGCGAAGGTGCTGGCCGCCACCGCCACCTGGGCCAAGGGCCTGAGGAAGGGCGCTAAGGCGGGCCGCAAGGGCCCAAGCCAAAGGGCCTTGGCCCCGGGGAAGTGCTGGCCCAAGAAACGCTCCAGGGCTACCCCTTCCGTGTACTGGCCCCAAAGCCCCTTGGCGCCAGGCACCGCCAGGTCCATGAGGCCAGCCGCCTGCGCCTCCGCCTCGAGGCGCACCCCCTCGGGCGGGGGCAGGGCCTCGGCCAGCACCGCACCCGCAAACCCCAGGGGCCAGAGGCAAGGAAGGGCAGCCCAGGGGTTCTCGGTTTCCACGGGATAAGGGAAAAGGGGCAGCTTGGCCGTGGTCACCTCGGCCACCAGGCGGTCAAAGAGGGGGCTGGGCTTTTTATAGAAAAAAACCAAGGGGCGGGGCTGATGGTAAGGGGGCCACATGGGCTTCCTCCTAAGCCGGGCGCAGGTCGGCGTACTTGAGGGAGAGGCGTTTTAACCCCACCCCGTCAAAGTGCACCGTTACCTCGTCCCCGCTGGCCGCCACCACCGTGCCCAGGCCAAAGCGGGGATGGACCACCTTTTCCCCACCGCGGAAGGCCCCAGGCTTGGCCCGGTGGGGAGGGGGAACGGGCTTGGGAGGGGGAAGGCGGTAGGGGTCATACTCCTCGTACAGCCCCTCTTCCACCTCCTCCAGGAAGCGGCTGGGACGGCTGGCTTCGGGCCGCCCGTAGACCTCCCGCTCCTCGGCATAGGAAAGGTAAAGCCGTTCCTGGGCCCGGGTTACCCCCACATAGAAGAGGCGGCGCTCCTCCTCCAGGCCCTCCAGGGTGCTCACCGAGGAGCGATGGGGCAGAAGCCCCTCCTCCACCCCCACCAGGAAGACCACGGGGAACTCCAGCCCCTTGGCGTTGTGCAGGGTCATGAGGGCCACCTTCCCCCCGGCCTCCCCCGGCTCCTCGGCCCGGGCGGTGAGGGCCACCTTGTCCAGGAAGTCCATGAGCCCCTCGGCCTCCCGGGCCGCCCGGAGGAGCTCCTCCACGTTTTCCAGGCGGTCCTCGAGGTCCTCGGGGTAGGCTTCCTTGAGGTAAGCGGGGTAGTCCGTGGCCTCCAGGAGATGGCGAAAGAAGGCCTCGGCTGGGCCGAAGGCGAGGTCCATGAGCTCCTCCATCAGGGCCAGGAAGTGGCGCAGGGGCTCGGGGCGGGGTAGGACCTGGGCCGCCACCTTCAAGGCCTCGTAGAGGGGAAGGCCCTTCTCCTGGGCAATAGCCTGCACCTTTTCCACGGTGGCTGGGCCGATACCCCGGGGAGGGGTGTTCAAAACGCGTTTCAGGCTCACCGCATCCAAAGGGTTCAGGGCCAGGCGGGCGTAGGCCAGAAGGTCCTTGACCTCCGCCCGTTCAAAGAAGCCCACCCCTCCCACCACCCGCGCCCCGATGCCCCGGCTGGCCAGGGCCTGCTCCAGGAGGCGGCTTTGGGCGTTGGTGCGGTAGAGGACCGCCACCCGGTCGTAAGGGGGGCCCAGGCGCAGCACCTCCTCGGCCACGAAGCGGGCCTCCTCCCGGGCATCCCGGGCGCGGAAGAGGCGCACGGGCTCCCCGCCAGACTTCACTGGACGCAGGGTCTTCTCCAGGCGCAGGGCGTTCTTCACGATAACGGCGTTGGCGAAGCGCAGGATGCGCTCCGTGGAGCGGTAGTTCTCCTCGAGGCGGTAGACCTTGGCCCCGGGAAAGTCCTCCGTAAACTGCAGGATGTTTTTGATGTCGGCGGCCCGGAAGGAGTAGATGCCCTGGTCCGGGTCCCCCACGGCCATCAGGTTGGCCTCCTCCCCCGCCAACAGCTTGGTGAGGCGATACTGGACGGGGCTTGTGTCCTGGTACTCGTCCACGTGGATGAAGCGGGCCCGCTTCCGCACCCGCTTGCGCACCTCCGGGTCCTCCTCCAGAAGCTTTAGGGCCAGGAGGAGGATATCGCCAAAGTCCAGGGCCCCCTGGGCCCAGAGGGCCTGCTGGTAGCGGTGGAGCACGTCCAAAAGCCGGCCCCGGGAAAGCCCAGCATAGTACTCAGGAAGGTCGGCCAAAAGCCTTTCCGGCGGCTCTCCGCGGTTCTTGGCCCGGTCCAACAGGGCCTTGATGGGCCCCGGCTTGGCCGATACCCCCAGTTCCTTCAGCACCTCCTTCAGGAGGGCCGTCTGGTCGTCCTCGTCGTAAACCACAAAGCCCGGCTTCAAGCCCACCCGCTCCCCATAGAACCTGAGGATGCGCAAGGCTGCGGCGTGGAAGGTGGAAACCCAAAGCTCCCCCGCCCCCTTGACCATGGCCTTGAGGCGCTCCCGCATCTCCTCGGCGGCCTTGTTGGTGAAGGTCACCGCCAGGATCTCCGAGGGGTACACCCCTCGCCGGGCCATCAGGTAGGCCACCCGGTGGACCACCGTGCGGGTCTTGCCGCTGCCCGCCCCCGCCACCACCAGGGCAGGGCCCTCAAAGTGCAAGACCGCCTGGCGCTGGGCCTCGTTCAGGGAGGAAAGCCAAGCCTCGTCCAGGGGTTTCCCCGACGGGAAAGCATCCACGGGGCCGAGTCTACCACGGGGTAGACTTTAGGGCATGGAGCTCTCCCCTACCCAAGACGGCTTCTTGGGCGAGATCGCCAAGGACTTCACCTTCGCCACCGTGGCCCGCCTGGCGGGAGGGGTGGCGGCGCGCCTGGCGGAAGAAGGCCTCCGCCGGGTGGTGGTGGCCCACGACACCCGTTTCCTGGCCAAGGAGATGGCGGAGGAGGCGGCAAGGGTCCTGGCGGGGGCGGGCCTGGAAACCCACCTCCTACAAGGCCCTGCCCCCTTCCCCCTCTTCGCCTTCGCCCTGGCGGAGAAGGAGGCGGCTGGGTTCTACCTGACGGCCAGCCGCAAGCCCGCCCCCTACCAGGGGGTCAAGCTCCGCCGCGGCCCCGGGAAGCCCCTCTCCCCCGAGGAGCTCTCCCTGCCCCCTTCCCCCCCGGAAGGACGGGGCTCCTTCGCCCTTTTGGACCTAAAGAAGCCCTACCTGGAACGCCTGGCCCAAAGCGCCGGCGAGATGGGGGAGAAGGGGGGCGTGGTCTACCTGGACGCCATGGGCGGAGCGGGCGGGGGTTTCCTGGCAGGGGCGTTTAAGCGCCTGGGCCTTGGGGCCGAGCTGCGGGAAATCCACCCCCTCCCCCATCCCCTCTTCTACGGGGTGGACCCCAACCCCGTGCCGGAAAACCTGAACACCCTAAGGGTTCTCCTCAAGGCCCTGGAACCCCCCGGGGTGGGCTTCGCCTTGGACGGGGATGCCGACCGGCTCGCGGTTTTCCTTCCCGGGGGGGAGATGCTTCCTTCGGAAGGGGTACTGGCCCACCTGCGGGAAGCCTCCGCCGGGCGGGAGGTACAGGGGGATGGGGAAGGGGGGTACCTCTTCCCCTGGCACCTGCCGGAAAAGGATGCCTTCCTGGCCGCCCTGCTCCTCCTGAAGGTGCTCCTATGAGGGAACTCCTCCCCGGCCTTTACCTGCTTCCCGTACCCATCCCCTACCCCTTGAAGACGGTGAACCTCTACCTCCTCAAGGGGGAAGGGGAGGTGGCCCTGGTGGACACCGCCTTGGGCACCAAGACCGCCCGGGGCACCCTGGAGCTTTACCTGGCCGAGCTGGGGCTTTGCTTCCAAGACGTCCGCACGGTCCTCCTCACCCACCACCACCCCGACCACTACGGCCTTGCGGGCTTCCTGGAAGGCCTGGGGGCTAAGGTCTACCTGCACGAGGAGGAGCTTGGGCGGGGGCATCGCTTCTGGCAGGAACCCGAGGCCTTTGAGGGGGCTTCCTGGCAGCTTTTCCTGGAGCACGGGACCCCCGAGGAGGCCCTTGGGGGCATCCGGGAAACCATGGCCAAGACCCGGGAAAGGGTCCACCCCCCAAAGAACCCCGTCCCCCTCCGGGAGGGGGAGGTCCTCGAGGTGGCCGGGAAGCGGCTTCGGGTGGTCTGGACCCCCGGGCACGCGGACGGGCACGTGGCCTTCTGGCTGGAAGAAGAGGGGGTTCTCCTGGCAGGGGATGCCCTTCTGGAAAGGGTTTCCCCCAACGTGGGCCTCTGGGCCTACACCCGGGAAAACCCCTTACGGGACTTCCTGGCCTCCTTGGAGCGCCTGGCGGGCCTCCCCGCCCAGGTGGCTTACGCCGGCCACTTTGGCCCCATCCCCCAGGTGGGCAAGCGGGCCCAGGAGCTAGCCCTTCACCACCAGGAGCGCCTCGAGGCCCTCCTCCGCCACCTGGAAGGGCCCGAAACCGCGTGGGAACTTTCCCTCAAGCTCTTCCCCCAGGAGCTGGACGCCGCAGGCAGGCGCTTCGCCTTTGCCGAAACCCTGGCCCACCTAGAGTACCTGCGCCACGAGGGGCAGGTGGGACGGGAAGGCCCCCCCTACCGGTACTTCCGGGCCTAAAGACCCTTGCCGGGTAGACCTTCCAGGAGTAAACTTTGACCCGGTTCAAGGAGGTGCCATGCATCCTTGGTACGCCCACTACGACCCCGGGGTTCCCCAGGAGGCCCCCAAGCCCTGGCTTCTCACCGAGCTCCTTCGGGAAAACGCCCGCCGCTACCCAGAAAAGGTAGCCTTGGAGTTCTTGGGGCGAAGTATTTCCTACCAACGCCTCTGGCGCCAGGTGGAAGCCTTCGCCAGGGGTTTACAAGAGGCCGGCCTAGAGCCGGGGGAGCGGGTGGCCATCATGCTGCCCAACTCCCCCCAGTTCGTCATCGCCTTCTTCGGCACCCTGCTGGCCGGGGGAGTGGCGGTGAACACCAACCCCATGTACACCCCCCGGGAGCTGCGCCACCAGCTCCTGGACTCAGGGGCCAAAGCCCTGGTCATCCTGGACCTCCTCCTGCCCCGGTACCAGGAGGTGAAGGCCGAGGCCCCGGTAGAGGTCCTGGTGCGCACCGGGATCCAGGACTACTTGCCCTTCCCCAAGAACCTCCTCTACCCCCTGACGCTCAAGCGGAAGGGCCAGTGGCCCAAGGAGCTGGAAGGCATCCCTTGGCGCGCCTTCCTCAAGGCCTGGAAGCCGGAGCCCGTGGCCTTGGACCTGGATGACTTGGCCCTTTTGCAGTACACCGGGGGCACCACGGGGGTGGCCAAGGGGGCCATGCTCACCCACCGCAACCTCTCCACCAACGCCCTGCAGGTGCGGGCCTGGATCCCCGATTTCCGCGAGGGGGAAGAGGTGGTCCTGGGGGCCATTCCCTTCTTCCACGTCTACGGCATGACCGTAGCCATGAACCTGGCCCTGCTGGGAGCGGCCAAGCTGGTCCTCTTGCCCCGGCCGGAGATCAAGCCCATCGTGGAGGCCATTGAAAAGCACGGGGTCACCCTCTTCCCTGGGGTGCCCACCCTCTACGTAGCCTTCAACAACTTCCCCGGGATTGAGGGGAGGAGCCTGAAGAGCATCCGCGCCTGCATCTCGGGCTCAGCCCCCTTGCCCCTCGAGGTGGCGGAGCGCTTTGAGAAGCTGACCGGGGCCAAGCTGGTGGAAGGCTACGGCCTCACCGAGGCCAGCCCCGTCACCCATTGCAACCCCCTCTACGGCCCCCGCAAGCTGGGAAGCGTGGGCCTTCCCTTCCCCGGGGTGGAGGCCAAGGTGGTGGACGAGGAGGGCAAGGAACTCCCCCCAGGCGAGGTGGGCGAACTCATCCTCAAAGGCCCCAACGTCATGAAAGGCTACTGGAACCGCCCAGAAGAGTCCCAAAAAACCCTCAAAGATGGCTGGCTCTTCACCGGCGACCTCGCCAAAATGGACCCCGATGGCTACTTCTACATCGTAGACCGCAAAAAAGACATGATCATCGCCGGCGGCTACAACATCTACCCCCGTGAAGTAGAAGAAGTCCTCTACCAGCACCCAGCCGTCCAAGAAGCCGCCGTCGTCGGCGTCCCAGACCCCTACCGCGGCGAAACCGTGGCCGCCTTCATCGTCCTCAAAGACGAGTACAAAGGCAAAGTCTCCGAAAAAGACATCGAAACCTTCTGCCGCCAAAACCTCGCCGCCTACAAGGTCCCCCGCATCCTCCAGTTCCGCGACACCCTACCCAAGTCCAGCGTGGGGAAGATCCTGAAGCGGGAGCTAGCCAAGGAGGTGCCCCGCCGGGCCTGAGCCGGCCTTGGACCCCACCCCCAGGGGCCCTCCACCCCGGGGGCCGCTTTACATTTCCTTGCTCAAGTTATATGCTTAAGGCAAAGGGGGTGAAGGTATGAGCGCCACTGGCCTGGAGGTGTTTGACACCACCTTACACAAAACGCATGCCTGGCTGAAGGCCATCATGGAGGCCTTGGGCCTCGAGGACCGGCACCGGGCCTACATGGCCCTGCGGGCGGTGCTCCATGCCCTGCGGGACCGCCTGCCCGTGGAAGAGGTGGCCCAGCTGGGGGCCGAGCTGCCCATGCTGGTCCGGGGGCTTTACTACGAGGGCTGGGACCCCACGGGCAAACCCCTGAAGGAACGCCACAAGGAGGAGTTTCTGGCCCACGTGGCCCGGGAGCTCCGGACCCCTTCCGGCCCAGCCCTGGACCCAGAGGCCGCGGCCCGGGCCGTGTTCCAGGTCCTGGCGCAAAAGGTAAGCGAGGGAGAGATCCGGGACGTGCAAAACCTTTTGCCCAAGGAGCTGCGCGAGCTCTGGCCCCGTTAGTCCAGCACGAAGCGGTCCTCGGTTTCGTGCAGGCGCACCCGGTGGACGATGCGCTGGTCCTGGCCCCCCTCTCCGGTCATGGCCACCACGGTCACGTAGGGCCGCAAGGGGCTTCTTAGCACCTTCTTGGTGAGGGTTTCCTCCACCTGGAAGATGCCGGCGGAGTTGTTCATGGTCACCTGGATCTCCACCGGCACCTTTTCCCCCTTGAGGATGCGCACCTCGTCCACCGCCAAGGCGCTGATGGAGTGGATGTCTATGCTCCCCAGGGCAAAGGCCTTGCGGCCCCGGCCCTTGGTGATATCGGTGCCGTCGGCCACGGCGGTCACCCCCGCCTCCACCGTGAGGGGTTCGGGGTTCAGGTCGTGGCTGTGGATGCCGTGGAGGATGAGGGCGCGAAGGGCCGTCCTTTGCTCGGGGTCCGGGTAGATCTTCTCCAGAATGCGGTTGAGGATGGGAAGGGCCAGGGTAACGCCGAAGGCCTCGTGGTGTTCCCGGTGCACCTGGTTGCCCAGGTCGTGGAGCATGGTGGAGAGGAGGACCACCACGTAGGCATCCTCCAGCTCCCCCGCCCCAGACTCCAGGGTGTCCAGCCGTACCCCCGCCTCGGCCAGAAGGCCGAGGATGGCCACGCTGGCCGCCCCGGTGAGGAGGGCGTGGACCCGGCCATGGTCGTTGTAGCCCAGCTTGCGCATGGTGAGGTAGTTGGCCATGTTCCAGCCTGCCCGGGCCTCCGGGTCCTGGATGAGAAGCTCATAGGCCCTTAGAGCCTTGGGAAAGGCCCTAAGGCGCTCGCGGATGGCCTGGTCCGCCTCCGCGTAGAGTTTGGCCTTGGGGCTGGCAACGTGGACCACGCGTTCTCCCGTCATGGGCAACCTTTACTTTACACAAAAAGAAAGGGGCCTTAGGGGGCTAGGCCCCCCTATTCCAAGCCCTTTTACTCGCCCTTGAAGTTAGGGGGGCGTTTTTCCAAAAAGGCCCGCACCCCCTCCTTCATGTCCTCCGTGGCTGAGGCGTAACCGAAGAGGTCGGCCTCGATCTCCAAGGCCTCGGCCAGGTCCAGGCCTTCGCCCCGCACCACGCTCTCCTTGGCCAAGGCCAGGGCGATGGGGGCGTTCTTGAGGATCTTCTGGGCCAGCTTTTTGGCCTCCTCCAGGGCGTCCTCCCCTACCTGGTTCACCAGGCCCAGGGCCAAGGCCTCCTCCGCGGGCACGTGCCGCCCGGTGAAGATGAGGTCCAAGGCCCGGCCCCGCCCGATGAGGCGGGGCAGGCGCTGGGTGCCCCCAAAGCCGGGGATGAGGCCCAGGCCCACCTCGGGCAGGCCCAGCTTGGCCTCCTTGGAGGCCACCCGCAGGTCACAGGCCAGGGCCAGTTCCAGCCCCCCGCCCAGGGCGTACCCGTGGATGGCGGCGATGGTGGGCACCGGCAGGGCGGCGATCTCGGCAAAGACCTGCTGGCCCAAGAGGGCGTACTCCCGGGCCATGAAGGGGTCCTTGAGGGCGGCGATCTCCTTAAGGTCCGCCCCGGCGGCAAAGGCCTTGCCCTCCCCGGTGAAGATGACCACCCGGGCCTCGGGGTCTTGGTGGATCACCTCGGTCACCTCGGCCAGCTCCTGGAGCAGGTCCTGGGAGAGGGCGTTGAGGGCCTCGGGGCGCTTCAGCGTGACCAAGGCGATGCCGCCTTCCACCTCGTAGGCCAGGTGCTCAAACTCGGGTATCTCCAGGATGAACTCGTGCTCGTGCTCGTGGGCCATGGCTTACACCTCCAAGAGGGCCTCGAGGGCCACCTCCACCATACGCCTCACCCCCTCGGCCAGCACCTCTGGGGGGGCCAGCTCCGGGTCGCCGATGCGGTTGGAAACCGTCAGGAGGGCCCCGGCCTTCACCCCCCGGAGCTTGCCGATGAGGAAGAGGGCGCTGGCTTCCATCTCAAAGGCCAACACCCCGTAGCGGGCCCAGGCCTTGGCCCCTTCCGGGGTGGTGGCGTAAAAGGCGTCCTCCGTGGCCACCAGGCCCACGTGGTGGGGGTACCCCTTCTTGCGGGCTTGGTCCCAGAGGGCGCGAAAGAGCTCGGGATCGGGCAGGGGCGCGTAGGGACGGCCCTCCAGGTACTGCCGGGTAGCCCCGTCCAGGGGCACCGCCCCTTGGGCCACCACCAGGTCCCCAGGGGCCAAGGCCCCGTCCACCGCCCCACAGGTGCCCACCCGAAGGAGCACCCGGGCCCCCAGGCTCACCAGCTCCTCGGCCACGATGCTGGCCGAGGGTGCCCCCATGCCCGTGGTCTGCACGGAAACCCGTACCCCTCGGTAGCGGCCCGTATACCCCAGAAGGCCCCGGTAGGAGGTGTACTGGACGGGATCCTCCAGGAAGGTTTTGGCGATCCACTCCGCCCGCCCAGGGTCCCCGGGCAGGAGGACCCGCTCCGCCACCTCCCCCGGCTGGCCCCGCACGTGGATGGGACTCATACCGCCCCATCTTACCCCATACCCCCTAAAGCTTCAGGGCGGGGAACCCCTCCACCAGGGCCTCGTCGTGGGTGGCCAGGACCAAGGCCGCCCCCACCTCCTGGGCCAGCTCCTGGAGGAGGCGGAGCACCTCTCGGGCCTGGCGGCGGTCCAGGCTGGCCGTGGGCTCGTCCGCCAGGAGGAGGCGGGGCCTGAGGTAAAGGGCCCGGGCCACCGCTACCCGCTGGCGCTCCCCTCCGGAAAGCCTCTGGGGCAGGAAATGGGCCCGCCCCCCTAGGCCTAGCCGCCCCAAGAGGGCCAGGGCCCATCCCCGGTCCACCCGTCCTGCCAGGTAGCCGGGGGCGAGAACGTTCTCCAGGGCCGTGAGCTCGGGAAAGAGGAAGTGGTGCTGGAAGACCAGGCCCAAAAAGCTCAGGCGCCGCCGGGCCAAGGCCCCTTGGGATAAGCCCCGGAGGGGCTCGCCTTCCCAGTACACCTCCCCCTCCTGCAGGGGCAAAAGCCCGGCCAGGAGATGGAGCAAGGTGGTCTTGCCGCTTCCCGAAGGGCCCAGCACCGCCAAGGCCTCCCCCGGGGCAAGGCGGAAGGAAAGGTGGCGGAAGAGGAAACCATTCCCGTAGGCGAAGCCCAGGTCCTCCACCTGCAACACCGGCCGCACCCCCCCATCCTCTAGGCAAAGGATGAAGGTTCGGTTAGAGTAGGGCCGATGCCCGGCAACCCCCTGTTCCAGGACCTAACCCCGGAGGAGGAGGCCTTGGCCCGCACCTACTTCCAATCCCTGGCCTACCCCAAGGGGAAGCACGTCTTTCGGCAGGGGGACCTGGGGCAGAGCCTGTACCTGGTGGCGGAGGGACGGGTGCGCCTTTACCGCACCCACCTGGGGGGACAGGAGAAGACCCTGGGCCTCGTGGGGAAGGGAGGGGTCTTCGGGGAGATGAGCCTCCTGGACGGGGGGGAGCGGAGCGCCAGCGCCGTGGCCGAGGAGGACACCCTCCTCCTGGCCCTGCACCGCGAGGCCTACCTGGCCCTGATCCGCCGGGTTCCCCTTCTGGCCCACAACCTGGCCCGCATCCTGGCCCACCGGCTGCGGGAGCTCAACGTGGAGCTGGACCTTCTGGCCTTTGAGGAGGCGGAAAGCCGGGTGGCCTACGCCCTCCTCAAGCTCCTGCGGCTAGGTCACGGACCCCGGCTTCGCCTGCGCCACCAGGACCTGGCCGCCCTGGCCGGGGCCAGCCGGGAAACGGTCACCCGGGTGCTCCACGGGTTCAAACAGCGGGGCCTCCTCCGCCTCGCCCCGGGGGAGGTGGAGGTGCTGGACCCGGGACTCCTGGAGGAGGTGGCCTTCGGTCTGGCCTAAGCCCCCAAGGAGGTCGTGCGCGTGCGCCTGAAGGTGGATGTCCTGCCCACAGAGGAGCTGGTCTACCCGGATGTGGTCCTGGTGGTGGACGTGATCCGCGCCACCACCACCGCCGCTTGCCTCTTGGAGGCGGGGGCGGAGGCCCTGTACCTGGTAGCGGGCCTGGAGGCCGCCCGGGCCTTCAAGGACGAGGACGTGGTCCTGGCGGGGGAGGTGGGGGGGCTGAGGCCCCCGGGGTTTGACCTGGGCAACTCCCCCCGGGAGGCCCTCGAGGCCCCCGTGGGGGGCAAGGTGGTGGTCATGAGCACCACCAACGGCACCAAGGCCGCCCACGCCGCCGCCAGGACCGCCAAGCACGTCCTCCTGGCCTCCCTCTACAACGCCCACGCCGCCGCCAGGCTGGCCCGGGAGCTGGCCACGGAGGAGGTAGCCATCCTCTGCGCCGGCAAGGAGGGACGGGTGGGGCTGGACGACCTCTACACCGCCGGGGTGCTGGCGGAGTACCTGGGCCTGCTGGGGGAGGTGGAGCCCGAGGACGGGGCCCGCATCGCCCTGGCCGTCAAGCGGGCCTACCAGGACCCCCTGGAGGCCCTTTCCCTTTCCGCCGCCGCCCTGGCCCTGAAGGGGGTGGGCCTCGAGGGGGACGTGCCCTTCTGCGCCCAGGTGGCCAGGAGCGCCGCCGTCCCCCTGCTTACGGGCCGGGTGGGGGAGGCCCTTATCTTCAAGCGGGCCCTTCCCGGGCAAGGGATCTAACCCGACTCCGCCAATAGCCCATGGAAGCGGCGGATGGCAAGGATCCCCTTCTCCAGGTTCACCAGGTCAAACTTCTCGTTGGGGGCGTGGAGGTTGTCGTCGTTGAGGCCCAGGCCGAGGAGGACCACCGGCGCCCCCAAGGCCTCCTGGAGTTCCGCCACCACGGGGATGGTCCCTCCCTCCCGGGCGTAGACGGGAGGCCGCCCCCAGACCTCCTCCAGGGCCCGGGCCATGAGGCGCATGGGGGGGCTTTGGGGGTCGGTGAGGACGGGCTTACCCCCGTGGAGCCGCCGGACCTCCATCCGGTACCCCGGAGGGCAGAGGGCCTTCAGGTAGGCCTCGGCCAGGTCCGCCACCTCCTCGGGGTCCTGGTCCGGCACCAGGCGCATGGAGAGCTTCAGTCCGGCCTCGGCGGGGATCACCGTCTTGGAACCCTCCCCCTGGTAGCCGCCGAAGATGCCGTTGGGGTCCAGGGTGGGCCGGGCCCAAAGCCGCTCCAAGGGGGAGTACCCCTCCTCCCCGGGCAGGACCTCCACCCCCAGCTCCCCCTTTAGGGCCTCCTCGTCCAAGGGGGGCCAGAGGCGCTTCTCCTCCTCGGAAACGGGACGCACCCGGTCGTAGAAGCCGGGGATCAGGACCCTCCCCGTGGTCCCGTCCTTGAGGCGGGCCAGGATCCAGCCCAGGGCCTGGATGGGGTTAGGGGCCACCCCGCCGAAGGCCCCGGAGTGAAGGTCCCGCCGGGCCCCCTGGAGGCGCACCTCCAGGTAGCAAAGCCCCCGCAGGCCGTAGGTCAGGGTGGGGGTGTGGGGGGCGAACATGGCCCCGTCCGAAACCAGGACCACATCGGCCCGAAGCTTCTCCCGGTGGGCCCGCACGAAGGGAAGGAGGTGGGGGCTGCCGATCTCCTCCTCCCCTTCCACCAAAAACTTCAGGTTCACCCGGGCCTCCAGCCCCTCCAGGGCCGCCACGTGGGCCCAGAGCTGCCCCTTGTCGTCCGAGGCCCCTCGGGCGTAGACCCTACCCTCCCGCACCGTGGGGGAGAAGGGGGGGCTTTCCCAAAGCTCCAGGGGGTCGGGGGGCTGGACGTCGTAATGGCCGTAGACCAGGACCGTGGGGGCCTCGGGGTCCAGGAGGCGCTCGGCGTAGAGGATGGGGTGGAGGGGGGTTTCGTGGAGCTCGGACCGAAAGCCCAGGACCTCCAGCCGTTCCTTAAGCCAAAGGGCCGCCCGGCGGACGTCCTTCTGGTGGCGGGGGTCGGTGGATACCGAGGGGATGGAGAGGAACTCCAGCAGGGGCTCTAGCGCGCTCACGCCCCCATGCTACCCTCTTCGGCCAGGGTGCCCCCCTCCAGGAGGAGGAGCCTAAGCCGGGCCACCTCCCGCTCAAAGCGGGCCTGGAGGGCCTCGAGCTCGGAACGCAGCCGCATGATCTCCTCCACCCCCGCCAGGTTCACCCCAAGCTCCTGCGTCAGGCGCCGGATCTCCCTCAGCCGCTCAATGTCCCGCTCCGAGTAAAGCCGCGTCTTCCCCCCAGACCGCTTCGGCTTAATAAGCCCCTTCCGCTCGTAAAGCCGCAGGGTCTGCGGGTGCATCTCCACCAGCTCCGCCGCCACCGAGATCACGTACACCGGACGGTCCTTGTCCATGGTCTTTAGCCCCTCCCGCTAAAGCCTCCTAACCCTTCTCATTATAGAGTAGGGGTGAAGCCCAAGCGCAAGGAAGCTCTCCGGGCGGCCTCGAGGACCCTGGGGGCCAGGGCATGGGCCGCCTGGGGGGAAAGGCGGCTGGCCGGGGCGGAGAGGGAAAGGGCCGCCACCACCTCCCCCCCGGGGCCGAAGACGGGGGCGGCCACGCACCGCACCCCCAGCTCCTTTTCCTCGTTGTCCAGGGCGTAGCCCTGGCGCCGAACCCTCTCCAACTCCCTTAGAAGGTCCTCCCGGCGGGTCAGGGTGAAGGGGGTATAGGGGGTGAGGGGAAGCCCCTCGGGCACCCCGCGGTAGGCCAGGAGGACCTTGCCTACCCCCGTGGCGTGCAGGGGGGCACGGGAGCCGGGGGCGGTGAAGAGGCGGACCAGCTTGGTTCCCTCCGCCTGGTCCAGGTACAGGGCCTCCATCCCCGCCGGCACCGCCAGGTTCACGCTCTCCCCGGTTTCCGCTGCCAGGGCCTCCATCTCGGGCCGAACCGCCTGCAGCAGGCTCTTCCTGAGATAGGCTTGGCCCACGGCGAAGGCCCGGGGGCCTACCCGGTACACCCCCTCTACCTCCTCCACGAAGCCCAGGCGGACCAGGGCCTGGAGGAGGCGGTACAGGGTGCTCTTGGAAAGCCCCGTCCTCCTGGCCAGGGGGGAAAGCCCCCCCTCCCCCAGTTCCGCCAGGGCCTCCAGCACCTTTAGGCCCCGCTCCAGGGTTTTCACCTCCCCAGCTCCCCGTTCCCTGGGCCTCGGCATGAATCCCAAGCTAGCATCTCCCAAGGTGTTTTTCAACAGACGAAAAACCATTTCGTCCCTTGACAAATCCCGCCGGCCTCCCGTAGGCTCAGGCCACCATGAAAGGCGTGGAGATCACCAAGGACCATCCCCTCCTCCAGGAGGTGCTCACCGAGGAGGCCCTGGGCTTCGTGGTGGCCTTGCAGCGGGAGTTCAACCCCGTGCGCAAGGCGCTTTTAGAGCGGCGCCAGGCCCTTTGGGAAAGGTATAGGGCCGGGGAGAAGCCCGACTTCCTCCCGGAGACGGCCTTCGTGCGGGGAGGAAGCTGGCAGGTGGCCGAGGCCCCAAAGGACCTCAATGACCGCCGGGTGGAGATCACCGGCCCCGTGGACCGGAAGATGATCGTGAACGCCCTGAACTCGGGGGCCAAGGTCTTCATGGCCGACTTTGAGGACGCCCTCTCCCCCACCTGGGACAACGTCATCCAGGGGCAGAAGAACCTGATGGACGCCGTCCGCCGCCAGATTGATTTCGTCTCCCCCGAGGGGAAGGCCTACCGCCTCAAGGAGGAGGTAGCCACCCTGGTGGTTCGCCCCCGGGGGTGGCACCTGGTGGAAAAGCATGTCCGGGTAGACGGGGAGCCCATCTCCGCCAGCCTCTTTGACTTCGGCCTTTACTTCTTCCACAACGCCCACGAGCTGGTCCGAAGGGGCAGCGGGCCCTACTTCTACCTGCCCAAAATGGAAAGCCACCTCGAGGCCCGCCTCTGGAACCAGGTCTTCAACTTCGCCCAGGACTACGTGGGCCTCCCCCGGGGGACCATCCGGGCCACCGTCCTCATTGAGACCATCCTGGCGGCCTTTGAGATGGAGGAGATCCTCTACGAGCTCAAGGAACACGCCGCCGGGCTCAACGCGGGCCGCTGGGACTACATCTTCAGCTGCATCAAGAAGTTCGCCACCACCGCCCCCATCTTCCCCGACCGGGCCCAGGTGACCATGACCGTGCCCTTCATGAAGGCCTACACCGAGCTCCTGGTCAAGTCCTGCCACATCCACGGGGCCCACGCCATCGGGGGGATGGCGGCCTTTATCCCCTCCCGCAAGGACCCCGAGGTGAACGAGCGGGCCTTCCAGCAGGTGCGGGCCGACAAGGAGCGGGAAGCGGGCCAGGGGTTTGACGGCACCTGGGTGGCCCACCCCGACCTGGTGCCCGTGGCCATGGAGGTCTTTGACCGCCACCTGGGGGATAGGCCCCACCAGAAGCACGTGAAGCGGGAGGAGGTGCAAGTGACGGCCCAGGACCTCCTGGACTTCCACGTGCCCGGGGGCAAGGTGACGGAGGCCGGCCTTAGGAACAACATCTCCGTGGCCCTGCAGTACCTCAACCAGTGGCTTTTGGGCAACGGGGCCGCCGCCATCTTCAACCTCATGGAGGACGCGGCCACCGCCGAGATCTCCCGGGCCCAGCTCTGGCAGTGGGTCCACCGGGGGGCCACCCTGGAGGATGGCCGCACGGTCACCCCCGAGCTTTACCAGAAGGTCAAGGAGGAGGAGCTGGAGAAGCTGGGGGGAAGGGAGGTGGGCCGCTACAAGGAGGCGGAGGAGATCCTGGACAGGCTGGTCCTCTCGGAGACCTTCGTGGAGTTCCTCACCCTGGTGGCCTACGAGTACATTGACTAGAACCCCAAGGGAATAGCCCCCTTGCCGTAGAGTAGAACCATGGGATTTCTGGAGGAGCTAAGGGCCCTTTTCCCCCCGGGCAGGGTTCTCACCCAGGGGGCGGCCCTGGCCCCCTATGAGTCCGACGCCCTCACCGCCTACCGCCAGCGCCCCCTGGCGGTGGTCCTCCCCGAAAGGAAGGAGGAGGTGGTCCAGACCGTGCGGCTTTGCCACCGCTACGGGGTCCCCTTCGTGGCCCGGGGAAGCGGCACCAGCCTTTCGGGGGGGTCCCTGCCCGTGGAGGGGGGGATCGTCCTGGCCCTCAACCGCATGAACCGCATCCTGCGCCTGGACCCCCAGGCCATGGTGGCCGTGGTGGAACCCGGGGTGGTGAACCTGGAGGTCTCCCGCCAGGCCGCCCCCTTCGGCCTCTACTACGCCCCCGACCCTTCCAGCCAGCCCGTCTCCACCCTAGGGGGGAACGTGGCCTTCAACTCCGGGGGGGCCCACTGCCTGAAGTACGGCATGACCGCCAACCACGTGTTGGGCCTCGAGGTGGTCACCCCCGAAGGGGAGGTGGTGCGGCTGGGCGGGGAAGGCCTGGAGGGGGTGGGGCCCGACCTCCACGGCTTCTTTGTGGGCACGGAGGGGCTTTTGGGGGTGGCGGTGGAGATCACCTTAAGGCTCCTCCCCAAGCCCGAGGCCTACCACACCCTTCTCGCCGCCTACGGGAGCCTGGAAGGGGCCGGGGAGGCGGTGAGCCTGGTCATCCGGCGGGGCCTCCTCCCGGGGGCCATGGAGATCATGGACCGCCTAGCCATTGAGGCGGCGGAGGCCGCGGTCCAGGCCGGCTACCCCAAGGCGGAAGCCCTCCTCATCGTGGAACTGGAAGGCCCTAAGGAGGAGGTGGCCGAGGAGGCCCTGGTCCTGGAGGAGGTGATCCGGGAAAGCGGGGCCCTGGAGGTGCGGGTGGCCGGAAGCGAGGCCGAGCGCCAAGCCATCTGGAAGGGCAGGAAGGCAGCCTTCAGCGCCGTGGGCCGCCTCTCCCCCGACTACCTGGTCCAGGACGGGGTGGTGCCCCGAAGCCGCCTGGCGGAGGCCTTGAGGGAGATCGGCCGGCTCTCCCAGGCCTACGGCCTGCGGGTGGCCAACGTCTTCCACGCCGGGGATGGCAACCTCCACCCCCTGGTCCTCTACGACGGCAAGAAACCCGGGGAGCTGGAAAGGGCCGAGGCCCTGGCCGGGGAGATCCTGCGGCTTTGCGTGCGGCTTGGGGGCTCCCTTACCGGGGAGCACGGCATCGGGGTGGAGAAGAAGGGGTACATGCCCGAGATGTTCGCTCCGGAGGACCTCCTGGCCATGGAAGGGGTCAAGAAGGCCCTGGACCCCAAGGGCCTGGCCAACCGGGGCAAGGTCTTGCCGGAGGTGGCCCGTGCCGGAGGTTAGGGCGACCAGCGTGGCCGAGGTCCAGGAGGCCGTGCGCCTCTACCCGCGCCTGAGGCCCAGAGGCGGGGGGAGCAAGCCCGCCCTCTCCACCCCCCGGGAGGGGGAGGTGGGGCTGGACCTCTCGGGGCTAAGGGGCCTCCTGGAGTACACCCCAGAGGAGTTCGTCTTCACCGCCTACGCGGGCACACCCCTTTCCGAGGTGGAGGAGGCCCTGAAGGCCCACGGCCAGTACCTCCCCTTCCACCCGCCCCTGAAGGGCAGGGGGGCCACCCTAGGGGGCACGGTGGCCAGCGGGCTTTCCGGCCCCATGCGCTACCGCTTCGGCGGGCTGCGGGACTTCCTCCTGGGGGTGCGGTTTGTGGACGGGGAGGGCCGGCTGGTCCGGGGTGGGGGCAAGGTGGTGAAAAACGCCGCCGGCTTTCCCTTCCACCGCCTCATGGTGGGGTCCTTGGGGGCCTTTGGGGTGGTGGTGGAGCTCTCCTTCAAGGTCTTCCCCTACCCCCGGGTCACCCGCACCCTCCGGGTGCGTCTGGGAAGCCTAGGGGAAGCCCTTGCCGCCCTGGAGCGCCTGCGAAGCCTCCCCCTGGACCTCCTGGCCCTAGACCTCCTCCCCCCCGCCACCCTGGAGGTGCGCCTGGGGGGCTTCCCAAGGAGCGTGGAGGCCCGCCTGAAAGGTATTCAGGAACTCCTGGGCCAGGAGGGGGAGGTGCTGGAGGAAGACGAGGCCCATTGGGAGGCGGTGCGGGACCTGGCCTTCCTGGAGGAAAGCCCTGTCTGGGTCAAGGTGCCGGCGGGCCTAGGGCGCCTTCCCGAGCTGGAAACCCTTCCCCTAGAGAGGCGGCGCTACCTCGCTGGGGGAGAGCTCCTCTATGCGGGAACCGACCCTGAGGGCCTGAAGGCCTTGCGGCAGCGGGGCCTGCCCCACCTGGTCCTCCGGGGGGCGGAAGAACCCCTCTTTCCCCCACCCCCCCAAGGCTTCTTCGCCAGGGTCAAGGGGGCCCTGGACCCCCTGGGCCGCTTTCCCTTAGGGTGAGAGCATGCAGCACCGGATCCCCGTGGAAACCCTGGGCCCGGAAGGGGAGGTGATGGCCCACGCCATCGAGGCCTGCGTCCACTGCGGCTTCTGCCTCCCCACCTGCCCCACCTACCTGGTCCTGCAGGAGGAGATGGACTCCCCCCGGGGGCGGATCTTCCTCATGAAGGAGGTCCTAGAGGGGAACCTGGGGCTGGAGGAGGCCCTCCCCTACCTGGACCGCTGCCTGGCCTGCCAAGCCTGCGTCACCGCCTGTCCAAGCGGCGTCCCCTACGGCGAACTCATCGCCGCCTTCCGCCTCCACACCGAGGGAAAGCGGCACCGCTACCCCCTGGAACGGGCGTACCGCCTGGCCCTCCTCCGCACCCTCCCCTATCCCGGGCGCTTCCGCCCTCTGGCGGAGCTGGGGGCAAGGCTCAAGCCCCTCCTCCAACCCCTCCCCCTCCCCAAGCCCCTCAAGGCCCCTCTGGAACTCCTCCCCCCCCGCCTGGAACGGGAGGAAGGCTACGCCGAGGTCTACCCCGCCAAGGGGGAGAGGAAGGCCCGGGTGGGCCTCCTCTTGGGATGCGCCCAGAGGGTTCTGCGGCCCTCCATCAACCGGGCCACCATAAAAGTTCTCCAGGAAAATGGCCTGGAGGTCCTGGCGGTGCGGGAACAGGTCTGCTGCGGAGCCCTGAACCTCCACGCCGGGGACAAGGAGGGGGCCAGGGCCTTGGCCCGGCAGAACCTACGGGCCTTTCGGGAGGTGGATTTCGTGGTGACCAACGCCGCCGGCTGCGGCTCGGGGATGAAGGAGTACCCCCTCCTCTTCCTGGGGGAGGCCGAGGAGGAGGAGGCGCGGCACCTGGCCGCCAAGGTGAAGGACCTGACCGCCATCCTGGCGGAGGTGGGCTTCACCCCGCCCCCACCCCCCAAGAAGCCCCTGCGGGTGGCCTACCACGACGCCTGCCATCTGGCCCACGCCCAAGGGGTGCGGGAGGCCCCAAGGCGGCTTCTGAAAGCGGCGGGGGTGGAGGTCCTGGAGCCCCGGGAGTGGGAGATCTGCTGCGGCAGCGCCGGCACCTACAACCTCTTCCAGCCAGGGATCGCCGAGGCCCTGGGGCGGCGGAAGGCGGAGAACCTTATGGCCACCCAGCCCCACCTGGTGGTCACGGGCAACATCGGCTGCCTGACCCAGATCCAGGCCTACCTGGACCCCCGCATCCCCATCCTCCACACCGCCGAGCTCCTCGCCCTCCTCTACGAGGGCCAGGCGGAAAACCTCCCCGCATGAGGGCGGCCTTCCTCAAGGAAGCCTTCCTGCAGGCCCTTAAGGCCACCCACCCCGGGGCGCTCACCGCCAAGGCCCTTCCCCCAAGAAAGCCCGACCTCATCCTGGCCGTGGGCAAGGCGGGGGCCGCCATGCTCCGCGCCGCCTTGGACCGCTACGGGGAGGTGCCCTACCACCTCACCCTGCCCAAGGGGCAGGAGGCCTTGGGCCTAAAGGCGGTCCAGGCCGGCCACCCCCTGCCCGATGGGGAAAGCCAAAGGGCCGCGGAGGAGGTGCTGGACCTCCTGAAAGGCCTCTCCCCCAAGGGCCGGGTCCTGGCCCTCCTCTCGGGCGGGGGAAGCGCCCTCTGGTGCGCCCCCTTGGGGATCAACCTGGAGGAGATGCGAAAGCTCACCCAAGCCCTCCTCCAGAGCGGGGCCAGCATCGCCGAGATCAACGCCGTGCGCAAACACCTCTCCCGCCTCAAGGGGGGGCGGGCCCTCCTGGCCACCCGGGCCCGGGTCCAGGCCCTCCTCCTCTCCGACGTGCCCGGGGACGACCCCAGCGTGATCGCCTCGGGCCCCTTCCACCCCGACCCCAGCACCTACCGGGAGGCCCTGGCCGTCCTGGACCGCTATGGCCTGGACTTTCCCGGGGCCAGGCGGGTGCTGGAGGCCGGGGCCAGGGGGGAGATCCCCGAAACCCTCAAGCCTGGGGACCCGGCCACCCGCCGGCTCCGCTGGCGCCTGGCCGGGGCCAACCTGGACCTCCTCAAGGCCGCCCGGGACTTCCTGCGGGGGGAAGGGTACAGGGAAGTCATCCTCTCCGACCGCTTCGGGGGGGAAGCGAGGGGCCTCGCCCGCTTCCACGCCGAGCTGGTGGCCACCATCCGCGCCCACGGGCTGCCCTTCCGCAAGCCCCTTTTCCTGCTCTCCGGGGGGGAGGCCCAGGTGAGGGTGCGGGGCGGGGGCCTGGGGGGGCGGAACCTGGAGTTTCTCCTGGCCCTCTACGCCTACCTCCAGGAACCCCTCTACGCCCTGGCCGCGGACTCCGACGGGCTGGACGGCCCCTCAGGGGTGGCCGGGGCCCTCCTCACCCCGGAGGTCTGGGGCCTGGGCCTGGACCCACAGCCCTTCCTGGCGGAAAACGATAGCCTAGGCTTCTTCGCCCGGGCCGGAACCCTCCTCACCCTGGGCCCCACCGGCACCAACCTCAACGATTTCCGCCTCCTCTTTGTAAACTAGAGGGATGTCCCTGGTGGCTAGCCTTTACGTCCACGTCCCCTTCTGCCCTACCCTTTGCCCCTACTGCGACTTCCACGTGGTGCGCCGGGCCCCGGGGTGGGTGGAGGCCTACCTGAAGCGCCTGGCCGAGGAGGCCCAGGCCCTTTTTGCCCAGCACCCCGGGCCCCTTAGGACCCTCTACCTGGGGGGCGGCACCCCCAGCTACCTGCGGGAAAGGGAGCTCCTCGCCCTCTTCCAGGCCTTACCCTGGTCCCTGGCCCCGGGGGCGGAGGTAACCCTGGAGGCCAACCCGGGCACCCTGAACCGAAAGCGGCTCGCCCTCCTCCGGGCCCTGGGGGTCAACCGCCTTTCCTTGGGGGTGCAGAGCTTCCAGGACCCTGTCCTCCGCTTTCTGGGCCGGGCCCACGGGCGCAAAGGGGCCCTTAGGGCGGTGGAGGAGGCCTTGGCGGCAGGCTTTCGCGTCTCCTTGGACCTCATCCTGGGCCTGCCCATGCAGGACGTGGAGAGGGACCTCGAGGAGGCCGCGGCCCTAGGGGTGGGGCACGTCTCCGCCTACACCCTGCAGGTGGAAAAGGGTACCCCCTTCGCCCTCCTGGGCCTAGGCGAGGACCCCGAGCGGGCCGCCTGGGCCATGGAGCGGGCAGCCGAGGTCCTGGGCCAGGCGGGCCTGGAGCGCTACGAGGTTTCCAACTTCGCCCGGCCAGGGGAGGAGGCGGCCCACAACCTGGTCTACTGGCGCAACGGCTTCTGGCTGGCCCTGGGGCCCAGGGCCACGGGCCAGTACCCGGACGGGGCCCCTGGGGTCTACGCCCTTCGCCGCACCCACCCGCCCCTGCCCCGCTGGCTCCAGGGGGAAGCCCCCGAGGAGGAGGCCATCTCCCCCCTGGGGCACGCCAAGGAAAGCCTGATGCTGGGCCTCCGCCTGCGGGAAGGGGTGGACCTGGAGGAGGTGGCCCGAAGGAGCGGGCTTCCTCTCCCTTCCCTCCTGCAGGAGGCCGTTTCCCAACTGGTCCAGGAGGGCTTCCTGGAGGCCGCGGGGCCCCGGATCCGCCCCACCCCCAAGGCCTTCCCCCTCCTTCACCGGGTGGTGCTCCGCCTCTGGGAGGCCCTTGACCCCCTCGAGGCCCCAGGCTAAACTTTGACTCAGTTCAAGGAGGAAGCCATGGACCTCACCGCATTGGGGAAAGAGGTACTAAAGGCCCAGCCTTTCAGCCAGCTTCTGGGGGTGGAACTCCTTTGAGCCCAGGAGGGGGAGGTGGCCTTCGCCCTCCCGGTACGCCCCGAGTTCCTCCAGCACCTGGGGGTGGTGCACGGCGGGGTCATCGCCGCCTTGCTGGATAACGCCCTCACCTTCGCCGGGGGCACGGCCCTAGGCCCCCAGGTCCTCACCGTGGAGTTCAAGGTGAACTTCCTGCGCCCGGCGCAAGGAGGGCGGCTTGTGGCCAAGGGCCGGGTGGTCCACGCCGGAAAGCGCCTGGCCGTGGTCCAAGGGGAGGTGGCCAGCGAGGGGGAACCCGGGCCCATCGCCCTGGGCCAGGGGACCATCCGCAAGGTCTAAGCCAAGGCCAAGGCGGCCCGGGCCCGGTCGGCCAGGGCGAAGAAGCGCTCCTTGGTGAGGGGGATCTTGCCCGTCACCAGCCCCTTGCCGGGCTCGTAGTGGGCGTGGAGGTGGATGTGGGCCCGGGGCAGGCGGAGGCCGATGCGCTTGAGCTGGGCATGGCGGGGGGAGACATCAGCCAGGAGAAAGGGCTCGCCCAGGGCGTCGGAAAGGGAAGCGGTCATGATGGTGGTGGGCAGGTCATAGGGGCGCTCCATGCGGTAGATGAAGTCGGGGAAGTCCGCCTCCTTTTCAAAACGCACCCCCTTTTCCCGGGCGTACTCCCGCATCCAGGAGAGAAGCTCCACCCAGGCCTCGTAGAGTTCCCGATCGTGGGAAGCGCTCATGGCTTGAGTATACCCGTAGGCCCCTGGGACAAAGGCCAGGGTGCTACAATGACCCTAACCCCTACCTCCCCAAAGCCCTATGGCCACATCCGCCCGCCTATACCTGTTGGACGAACCCCACGCCCTCTGGGAGGGCTGCCCCTACCCTCTTCCCCCTTCGCGGCCGGGACAGCTTCTGCTCTTCCTAGCCTACCGGGGGGAGTGGGTGGCGCGGGAAACCCTGGCGGGCCTTCTCTGGCCTGAGATCCCCGAGGAAGAGGCGCGCCACAACCTGCGGGTGGCCCTGCACCGGGCCAGGTCCCTGCCCTGGGCCCAGGCCGTGGAGGTCAACCGGGAACAGGTGCGCTTCGTCCTGGTTACGGATGTGGCCGAGTTTCGCGCCGCTTTGGGACGGGGGGATTGGGAGGAAGCCGTGCGCATCCACCGCAGGCCCTTCCTTATGGATTTTCCCCTGCGGGAAGCCCCGGCCCTGGAGGACTGGGCCTCCCTCGAGCGCCAAAGCCTCCTCGAGGCCTGGCAGTACGCCGCCAAACGCAGGGCCCAAGAGCTGGAGGAAGCCGGGGAAGCCGAGGAGGCAAGCCGGCTGCTCCTGGAGGTGCTGCGGCACGATCTTCTGGCCGAGGATGTCCTGCAGGCCTACCTGCGGGCAGCCCAGATGGCCGGGCAGCGCGAGGCCGCCCTCAAGGTCTACGACCGCTTTCGGCGCGAACTTGGGGAGGGTTTGGGCCTCGAGCCCGCCAGGGTTACCCAGGAGCTGGCCCAGGCCCTCCGGCAAACCCAACCCCTGGCTGCCCCCGCCTCCCCCCGCCTTACCTTCCCCCTGGGGCTCCTCCACCCGCCGCGGATGGTGGGGCGAGAGGAGGAGCTGACCGCCTTGCGCCGGGCCCGCTTCGCCCTGGTGAGCGGGGAAGCCGGGGTGGGCAAGACCCGCCTCCTCCTGGAGAGCTTCCCCGAAGCTCCCCGTCTCCGGTGCCTCGAGGGCCTGGAAAACCTGCCCTGGCACCCCATCCTGGTCCACCTAAGGCGGCATCTGGACAAGCTCCCCGACCTCGGCCCCTACCGGGAAGACCTGGCCCGGCTGTTGCCCGAAGCCTTCCCCGGCCTAACCCCGCCCCCTCCCGAGCCCGGGAGCAGCAAACCCCGCTTGCTGGAAGCCCTGGCTCGGAGCCTGGCCTCTGCAGAAAGGCTTCTCTTCGATGACCTCCAATGGGCCGACGAGAATACCCTGGAACTGCTCCTCTACCTCCTGGAACGGGGCCAACCCTGGATCGGGACCTACCGGCCCCAGGAGGTAGGCCCCGCCCTAAAGCGGACCCTGGAAGCCCTGCACGCCCACGGGGTGGAAACCGTGGTCCTAAAGCCCCTGGAGGCCGATGCGGTACATGCTCTCCTGGCCGACCTCACGGGAGCGGAGGAGGGCCCACCCTTGTTCTCCCGTTGGCTCCGGGGGAAGACCGGGGGCAACCCCTTTTTCGCCCTGGAGGTCCTCAAGACCCTCTTTGAGGGCGGGGTGTTGCGGGAGGAAGGAGGTCGCTGGCGCACCCCCCTGGACGAGGTTACCCGCGACTACACCGAGCTCCAAGTACCCCCCAAGGTGGCCGGGGTAGTGGCCCGCAGGCTGGGGCGGCTTTCCCCCGAAGCCCTGCGCACCCTCCAGGCGGCCAGCACCCTGGGGGAAGGTTTCTCCCCCCAGGTGTTGGCCCCCATGGCGGGGCTTTCGGAATGGGCGGTCATGGAGGGGTTGGAAGAGGCCGAGCAGGCGGGGATCGTGGCCGGAAACGGCTTCGTGCACGACCTCTTCCGCCAGAGCATCTACCAGGGCCTCTCCCAAGCCCGGCGCCAGTTCCTGCACGCCCAGGCAGCCCAGAGCCTCCAGGGCCAGGCCCCACCCCAGGTGGTGGCCGAACACTGGTTCCAGGCCGGGGCCCACGGCGAAGCGGCGCACAACTGGCTGGTGGCGGCCAGAGCGTACCTGAAAAGTTCCCTGCCCGAGGAAGCGGCGAGGGTGCTGGAGCGGGCTTACCCCCACGCCCAAGGCCTCGAGGGGCCGGAGATGGCCGCCCACCTGGCCCGCAGCTACCGGGAGCTGGGCCAGTACGCCCAAGCGCAACGATGGATCCAGGAGGCCCTGCGCCACCCCTCCCCACGTTGGCAGGCGGATGCCCTCGTGGAGCAGACCTGGGTCCTCCTGGGGGAAGGCCGGCTGGAGGAGGCGGCCAAAGTGCTGCAGGAGGCCCAGGAGATCCAGGCCAGGCTGGAGCCTGAACCCCTGGAGGAGGGCTCCTTGGAGCTGGCCCTGGCCAAACTGCGCTCCAATCTAGCCTTCCGCCAAGGCCAGTTCACCGCTTCCTGCCAGACCTTGGAACCCCTGGCGGCCCGGCTGCGGACCCAAGGCCCCTCCCTGGCCCTGGCGGGAATCCTGGTCAGCCTGGGGAGCAGCTACGACCACCTGGGCCAGGAAACCCAGGCCATCGCCACCCTGGAGGAGGCGCTTCAGGTAGCCCAGAAGGTGGGCGCCCGCTACTACCTGGTGGACGGGGCCAACAACCTCCTGGGGTGCCTGATACGCCAGGGGCGTTGCGAAGAAGGTCTTGCCCAGGCGAAGGCCGCCCTGGCCCTGGGCGAGTACGAGGGCACCGCCTTCTTGCGCAACAACCTGGCCGTGGCCTATCTCTCCCTGGAGCAGGAAAAAGAAGCGCTGGCCCTCTTTGAGGCCAACGCCCACGGGGCTCCGGACGCCATGCTGCGGGTTCTAGCCTGGGCGCGGCTAGCCGAACTCTACCCCCGCCACGGGTTGGCCGGCGCGGTGGAACATGCCCTGGACCAGGCCTTGGAGACCGCCCTGGGCATGGACCTCCAGGCCGTTCCCGTACGCTTCCTCCTGGCCCTCCTGCGCTGGGGAACCGAGGCCCAGCTTCGGCGGGCCGTCCCCCTCCTGCAGGAAGGGGTGGCGGAAACCCTGCCCCCACCCTGGCGGGAGGCGTACCTCGAGGCCCTGGCCCAACGCGGCCTCCCCCCTTCCTCCCCCTGAGGCGCTGGTGTAACGGGGCCAGCCTACCCTGAGCCCCATGACCCCTAAGCTGCGCCGGAGTTTCCTGGTGCGAGTGTACACCGCCCCTGGCCCGGACGGCGTTCCCCGCTGCTCGTACCGCGTCCACGACCTGAAGACCGGTCGGGAGGTGGAGTTTGCCACCTGGGAGGAGCTGCAGGCTTACCTGCAGCGCCGCTGGCCAGGCCGGCTGCGCTGAGACGCTGGTGTAACGCGGGGCTTCTACAGTGGCCTAAGAAGGCATTGCTCGCAGATTTTGGAGGGAAACACAGCCGAGGAGGAACCCATGAAACCGCGTACTCAGGCACCGATGGTTCGCTTTCGCCAGTACTGGCTGGCCCTGGCCTTGCTGGGGCTCCTGCTGAGCTGCGCCCAGCCCAGCCCGCCCCCGCCGCAGGTGGTGCGGGTGGAGGTTGCCCCGGGGGGCCTGTTGCTCACCCGCCCGGGGGAGAGCCAGCCCCTGAGCGCCAGGGCCTACGATGCCCAGGGCAAGGAAGTCAAGGCCAACTTTACCTATAGCTCCAGCAACCCCGCCGTGGCCAGCGTCACCCCGGAGGGGCGGGTCACGGCCCAGGCCGACCTGGGTTCGGCCCGGGTGGTGGTGCAGGCCGGGCAGGCTAGGGCCGAGGTGGGGGTGATGGTAGCCCAGCCGGTGGCGGGGGCCACGCTGGTCTCGGATAGCCAGGTTGTCCGCATCGAAGGCACCGACCCCAACGCTCCCTTCAAGGTGGGCTACCGCTATGTGGTCACCCTGGAAGGGGTGGATCCTCCGGCCGTGGGGAGCGTACTGATGAGCCAGGGCAGCCTGCCGGTGGCGGGAAGGGTGGTGGAGGCCCGGCAGAGCGGGAGCCAGACCCTGGTCACCCTCGAGCTGGTGCCGCTGGGGGAGCTTCTCACCCGGTATCGCCTCGAGGAGACCTTCAACCTGGCTCACCTTCCGGCTGTTGTGCCCGACAGCGTGGGTTCGAACTTCGATGTGACCCCCAAAGGCAACGGCCAGTACACCCTCCGGCTCAAGCCCGGTAGGGTGATCCGCACCACCGCCCGCCCCGCCGGCAGCGTGCGGCCCATGCGGGAGTTCGAGGTAGGCCCCCTGGAGTGCGAAACCGAGTTGAGCCTCGTGGACCTTTCGGTGGACGAGGTGGAGGTCGAAGTAGACCTGTCCTCCATCGGCTTTGAACTCCTGTGGACCGAGGCAAACAAGAAGTTGTTGATGGTAGGCAGTCCCAAGGCCAAGCTGGCTTTCAATCCCTCCCTGGCGGCGGCCCTGGAGGGCAGCCTGGAGTGCAAGCTGGAGTTCTTTCAGATACCCTTGCCGGTGCCAAGCGTCCTCTCGGCGATAGCGCGCCTGTACATTCCCGTGGGGGCAGGTTTTGAGATAAGCGGCAAAGTGCCGGTCGCGGGCGTGGGGTTCGAGTCCAGCACGGAGTACCTCCTGGAGCTGCGGGCCGGGGTGGAGTGCACCCCCACCTGTTCCTTTGCCCGCCGGTTTGAGCGGAGGGAGACCCAAGCCGAGTTCAAGTGGGTTCTGCCCCGGGAGATACCCCGTGGCCTTAAGGTGGAAGCCGAGGCCAGCGGGTTCCTGTTCGCCACCATCAACACCGGGTTACAGGCCCACATCACCAACACCGGCAAAATCTTCGGTGTCCGGATAAGCGACTTCGAGTTCTTCGTGGCCAAGGCGGCCTTGAAGCTCGATGGAAAGCTGGCCTCGGAGGAAACCCAGGTGCGCGACCCCGAGTTTGCCGCAAAATATGGCCTTTCCCTCGAACTGAGCCTGAAGACCGGCAAGGACCTGCAAGAGGCCCTGGAGGCCTTGGAGATCCTGGTTACGGCGATAAACCTCAAGTTCCCCTTTGAGCTGGGCTCCTCCCCCACGGCCACCACCCTCACCGCCGACCGCAACAGCTTCCGATTCGGCGACGAGGTGCGCTTCCGGGTAAAGCTGGATAATACCGAGTTCCCCGTTCTGGGCTACCAGGTGGAGGCGGTGCGCGTCTACCGCAACACCGGCACCCCCGAGAACCCCGTGCTGGTGCTGGCCAACCAGGCCACGGCCTCCCCCGGCCAGACCGAGTTCGAGATTCCCTGGGTGGCCACAGAGGATGGCCAGGTGGTGGAGGGCAGCGGCGAGCGCACCCGGCACCACTTTGTGGCCTTCGTCAAGACCAAGCCGCTGGACACGCGCCTCGAGCTGGGCGGCATCAAATCCTTTACCGGAGCCCGAGGTGAGCTGGACCCCACCTTCGGCTCAGGGGGGAAGGTGACCACGGATTTGGGCTCGAGCTTTGACGGAGCCCATGCCCTGGTCCTCCAGCCCGACGGCAAGCTGGTGGCGGCGGGGTATAGCTCTAACGCCTTGGGACTCGCCGACTTCGCCCTGGTGCGCTACAACCCGGATGGCAGCCTGGACACCTCCTTCGGCAGCGGGGGCAAGGTGACCACGGAGGTGGTCCAAGGCGATGACAAAGCCTACGCCCTGGTTCTCCAGCCCGACGGCAAGCTGGTGGCGGCGGGGTATAGCAGCGAGGGCCTCGGCGACTTCGCCCTGGTGCGCTACAATCCGGATGGCAGCCTGGACCCCTCCTTCGGCACCGGGGGCAAGGTGACCACGAATTTTCACTTTGACGTAGCCCACGCCCTGGTTCTCCAGCCCGACGGCAAGCTGGTTGCGGCGGGGTGGAGCCAGATTGGCAGCAACTCTTACTTCGCCCTGGTGCGCTACAACCCGGATGGCACCCTGGACACCTCCTTCGGCAACGGAGGTAAGGTGACCACGGAGGTGGGCTCGAGCAGTGACGGAGCCAATGCCCTGGTTCTCCAGCCCGACGGCAAGCTGGTGGCAGCGGGGTATAGCCGGAACGCCGCGGGCGACTACGACGTCGCCATGGTGCGCTACAACCCGGATGGCAGCCTGGACACCTCCTTTGGCAGCAGGGGGAAGGTAATAACGCCGGTCTTTTCGACCTTTGGAAGCGCCCTGGTTCTCCAGCCCGACGGCAAGCTGGTGGCAGCGGGGTTTAGCACGAACTCCGCGGGCAACGATGACTTCGCCCTGGTGCGCTACAATCCGGATGGCAGCTTGGACAGGTCGTTCGGCACCGGGGGCAAGGTGACCACGGATTTGGGCCTCCCCCGTGACATAGTCCACTCCCTGGTCCTCCAGCCCGACGGCAGGCTGGTGGCAGCGGGGTCAAGTAACAACGACTTCGCCCTGGTGCGCTACAACCCGGATGGCAGCCTGGACCCCTCCTTCGGCATCGGAGGGAAAGTGACCACGGCGGTGGGCTCGAGCTATGACATAGCCCATGCCCTGGTCCTCCAGCCCGACGGCAGGCTGGTGGCGGCGGGGCGGAGCCGGAACGCCTCGGGCAACTCCGACTTCGCCCTGGTGCGCTACCGCTAACTGGGGCACGGACATCGGAGGTATTTATGTGCCAAGAGAATCGGACACCCCGGCTATCCATCCCCTCCTGGGCTGCCACCGCAGGCTGGCTGCTCCTCTGCCTGGCTTTTGCGCCCCATGCGCTGGGCCAGGAGATGCGGGTCGAGACGGTCAGCTACAAAAACGGCGACCTCGAGCTGCGTGCCTTCCTCTACCGCCCCCCAGGCCCAGGGCCGTACCCCGCCATCGTCTACAACCACGGCAGCGAGAAGAACCTGGCCTACATTGACCGGCTGGCGGTGCCCTTTGTGCGGCAGGGCTACGTGTTCTTTGCCCCCAACCGCCGGGGCCACGGCCGCTCACCTGGCACCTACATCCTGGACGTGCTGGGCACGCTGCGCGGGGCGGAGTGGAGCCAGGCCCTGGTGCGGCTGCACGAGGAACAGCTCTCCGACCAGCTCGCCGGGGTGGCCTACCTGAAGAACCTGCCCTTCGTGGACTCAGGCCGCATCGGGGTGTATGGATGGTCGTTCGGGGGCATCCAAACCCTGCTGGCCGCCGAGCGCTCCGAGAGCGGCTACAAGGCGGCGGTAAGCTGCGCGGGGGCCGCGCAAACCTGGCCGGCTTCGCCCGACCTGCGGGCCCGCCTCTCGGAGGCCGCCCAAAAAGCGGCGGTGCCCCTCTTCTTGCTGCAGGCCCAGAACGACCACTCTCTGGCGGCCATCGAGGGCCTATCGGAGGTGCTCCGCCGGAGCGGGAAGCCCCACCAGTCCAGGGTGTACCCCGCTTTTGGCACCACCCCCCAACAGGGGCACGAGTTCTGTATCCAGGGAAGCGAGATTTGGGGGCCGGAGGTGTTTGCCTTTTTTGCCCAGCACCTTCGCTGAGGCCACAGCCCACCAGCCCCGGCCTTCGTTCTGGTGGCCCCGCCCCTAGGGCGGGGTTTTCTCTTGAGACGCTGGTGTAACGCGGGGCTTCTACAGTGGCCCTCGAGGCTCCCCCAATCCAGACCGGGGCAGCCCTCAAGAGGAGGACGTATGCGGCACAGGATTCTCTGGAGCATTGGGGTGGTTCTGGTGCTGCTCGGCGGTTGCGGCAACCGCACCGAGGCACCCGAAACCAACCCCCAGGTATTCGTGGGCGAGGTTTCGGGTACGGATGCACTCATCGCCTTGGTTGTGGGAGAAAAAGGCGTACTGGCCTACGTTTGCCAGGGGGCAAACAGCTGGGACAACACCACCTACGGCGGCTACACCGGCTGGTTCCACGGCTTGGCCAGGGGAAAGCAATTGGACCCCATGACCTCCGCCAGTGGCCACGTTCTCTCGGGGCAGATCGCCGACCAGACGGCCAGGGGAACCCTCACCCTGGCCAACGGATACATCCTGAACTGGACCGCCGAGAAGGTGCGTTCCGGCACCGGCGCTGGGCTTTACAGCCTGGAGGAAAACGGGATGCTCACGGGGTTGATCGTCACCAACGCTGGGAAGATGGCGGGGGCTTCGCGCCTCAACACCGGCGACGCCAGCAGCCTCTCGGCCCCGGTGCAGGTCGTCACCGCCCCTAGCAGCACCAACACCTCCCCTACGGTGAGCGTTACCTTCCCCAACCTGGGTACCCGCGACCTCAACCTGACCCCCGTAGACCTGCTGCGTCATATGGTTGTTCCCGATAGCCCCACCATTATCGTTCTCCTTCACGGGGCCACCGCCCGAACCCCGCTGGACAACCCCCGGGTTGACGGCGTGCCGGGCACCCGCAAACACGCCCGCCACTTCTGGACCTACCCCTTCGTGGCCGCCCTCTTGGGGGCCGACCCCAGCAAAAATGCCCCGCTGGTCACGCTCGAGGGCACCGACATCACCGGAAGTGCCTTCCTGAACGTGGGGCTAACCCTACCGGGCCAGGGCACCGACCAGGTGCCCGCCTCCGACCAGTGCACCCTGGGCGACATGGCCACCGCCGAGCGCTACACTCGAGGCCAGACCACTCCCCCTAAGCTCACCGTACTGCTCGGCCACCGGGATGCCAAGGACAGCCTGGTGGAGCAGGCCATGTACGCCGTGGACCAGATTTACGCCTGCGTCACCCTGTTCGAGCAAACCTTCCGCCGCAAACCCAAGCTGCTCTTCGTGGCCCAGAGCTGGGGCGGTCTGATCACCCGCTTTATCCTGTCCAACCCCACCCGGGCCTCCCTGCAGGCCATCACCAGCCCCACCTCCCTTCGCTTTCCCACCGACAACGCCCGCTACGACACCGGTGACCTTTCCACCCGGGTCAAGATGGACTACCTGCGCAACCTCACCTACTACGCCGTCACCATGGCCACGCCTCACCAAGGGGTGCGCATCATAGACCGGGCCAGGGAAGTGGTTCAGGTCGTGGGCATGCTCCGGGGTACCCTCGCCGCCGCAGATCGGGAACAAGAAAACCTGCTCAACGCCTGGCGCAATGCGGTGAGCCTGCTTCTCAACCTTCCCCCTGCCGATGCCCTCCGGGCCGAGCCGGTGGTGGCGGCCCTGGCCTGGTTTGAACAGTTCGCCGAAAGCACGTTTGCCATCAACCGGGTCTGGGCCGAGAGTCACACCGGGCTATGGGTAGCCCTGAATACCGGGCCGCTGCACCCCAGCCGGGCCATCCGCACCAACCAATCGCCCATCGTAGGCGCCAAGAACCAGCTCATTCCCATATACGCCTTCGGCGCCCGCAACCCCGGCAGCACCGTGGCCGACACCCTCAACCTAGGCCAGATTCCCGGCGACTTTCAGGCCCTGGGCAGCCTGCAAAAAGGCGCCACCAAGCAGAGCTGGGTTATACAGGCCATCGGCGGGGATTTCGTCTACCGCTTCTTGGATCTGAGCACCGGCCCCCGCACCCCCTTTGCGGGTTTTGCCAACCAGCTTGACCGCACCGAGCGGGTGGATGCCATCGCCCTGCTGCGTACCGCCCTGGATTCGGTAGCTCCCCAACTCAACCTTTTCTTCCGCGCCCAGTTTGGGAGCGACTCGGCCAGCCTGCTGCGCTTCATGCTGGAGCAACTTCGGGTGCCAAGCACCTCGCTGGTGCCCATCTTCCTCAATCAGGGGTTCACGGTTGACCTGGGCGGCAGCGTGCAGTTGCCGGTACCCCGGCTTTCCTGCCAGGGCCGGAACATCACCCTGGACTATGGCCCGCTGGTCATTGCCCTGGTAAGCCACTACGGCAGCTTACAGCAGGCCGCCAGCGCCCTGGCCTCGCTCAGCTTCCCTGCTCTGCTCAGTGCCCTAAACAGTCTGGGTGGAGATTTCAGCGGCCTGGCCACCAATCTTTCCACCTGGATGACTCAGACCCTGAACACCCTACAAAACCTTCCTGTTGCGTGTGTTAATCCGGCCAACTGGACGCTCTCCTGGCCCCTGACCAGTGTCCCGGCCCCCAGGGCTGTTCCTACCGGCGTGCCGGTGAGCGACCGGGTGATTGACAACGACGGCCTTGCCGAGTTCGACTCGGCCATGGGCTTCCGGCTGGGCACCTCCATCAACGAGTTCTTTGACCACACCCGCACCGACTTTGTGGTGGACAACAAGCCCCTGCCCGGCTCCTGGTACCGCCGCTACCGCAGCGATTTGGAGCAGTTAAACCACGACACCATGCGAGAAGAGGCGGGCCGATTTGTCTGGACGGACATCCTTTCGCGCAATCCCGGCCCCTTGCCCAGTGAACAGGGCGACCTAAGCGTTTACCCCCAGTAAAGGTGTCTTTCGGTGGCAAAGGATGAGGGCCCCGGCGTGATGCCGGGGCCTTTCCCTTTGGTGGGCGCGAGTGGACTTGAACCACCGACCCCTACCGTGTCAAGTTAGCTCTGCACCCCCATTTCACCCCCACTTAAAACACGACAAACGGCATACACACGGCAAAAACCGGTCGTGTCAAGAGTTATGTGTAAGAGTCTGTGTACGGGGGGCATACCGCTCCTGAAGCATCTTCTCCAGCACCTCCTTCACCTCCGAGAACCCCTTTAGTTTCCGTTCTGCCCACCTCCCTTCCTGCCTCTCCGACTCCAGGTAAAGAAGCTTGTACACCGCCTCTTCCTTAGGAAACTTGTGGTCCCGCACCTTCGTCCCCCGCCGCACTTCCCGGATAAACCGCTCCATCAGGTTGGTGCTCCGCAGGTACGGCCAAAGCACCTTGGGGTACCCGTAGAACCGCAGGAAGGCCCCCGAATCCTGTACCCAAAGCCCCACCACCCCCGGGTACCGCGAACCCCAGGCGGCCTTCACCTCCTCCAAGGCCCCAAGAGCTTCTTCCCGGCTCTCCGCCCCGTACACCCGCCTCAGGTCCTCCGCCAGCAGGCCCCGGTCCCGCGCCCGCACCTGGGACAGGCTCCACCGCACCCCGTGCACCACGCACCGCTGCCATTCCGCCTGAGGGTAGACCCTGCGGATCGCTTCAGGAAGCCCGGGCAGCCCGTCGGTGATGAAGAGCAATACCCGCCGCAGGCCCCGCTGCCAAAGCTCCCCCAGGACCCCCTCCCATCCCAGGGCGCTCTCCGTGGGCAACAGCCAAAACCCCAGGACCCGCCTCTCCCCATTAGGGGCGATGCCCAGGGCCACATACACGCTTTCCCGTACGATCCCTTCTCCTTCCCTGAAGACCTTTAGGGAAAGCCCGTCCAGGTAGACGAAGGCCATCTCCTCGGGCAAAGGCCGGGTGCGGAAGGCTCCTGCCGCCTCCAGGACCTCGTCCGTCAGGGCGCTCAGGGTCTCGTGGGAGTAGCGGTGGCCTAAGAGCAGGCTCAGTATCTCGGCCGCCTTGCGCTGACTGACCCCGGCGGCGTAAAGGGCTACCGCCACTTCCCCCACGTCCACCAGGCGGCGGACGTAGGGCTTAAGGAAAGCCGGGTAATACCGAGATTCCCGATCCCTAGGGACCTTCAGGTCCACCTGGCCGAAGGTGGTCTCCAGCTTGCGGGGGTAGTAGCCGTTCCTGCGGCCTCCGTGCACCTGCAAGAAGGCCGTCCGGTCCAGCTCCAGAACCGTCTGCAGAACCTCGGCTACTGTCTCCCGCACCGCTTCCCTCAGCAAGATCCGCAAGGTATCCTGGTCCACGGGGCACCTCCTCGTGCTAAGGTGTGCCCCCCTATTAAACACGGACCCTTACACATAAATCCTTACACGACCCAAAAACCCGCACGAACGCTCACCAAAACGGAACCAATAAACCCCCGCACCCCCTCTCCATTGAGGGTAGATTGAGGGTAAGACGAGAATGCCGTCCAGGACAACACTCTTACGGCGTTTTTTCTTGTCATTTGGCAAGGGGGGGCTAAACTTAGGACGTGGGGTGCGAGGAGGTTTGGGAGAAGGTTTGGAAGGTTCTTGAGGAGCAGGGGGAGAAAGGAAGGGCGTTGGGCGTTCTGGTTCTGATTGGGTTTGACCTGGATGCCCGGAATATTGGTGAGGTTCGCCGGGTCATCCGCGAGGTGGCTCAACATCTCGCCTTTTCCTTTCCCTCCGAGGCTTTGGATCAATTAGCGGAAGCCTTGTGGGACTGCCCGGAGTTCCTGGAAATTCTCACGGAAATAGAAGACGCGCCTTCTCCCCTCCTCAACCGCCTCGCCACGCACCCTGACCCCCACGTGCGGGCCAAGGTCTGCGGCCACCCTAACGCCAGCCCCGATACCCTCCGCCAGCTCTACCAACAACCAGACCTCCCCGCTTGGTGCCTCCAAGCCCTCGCCAACAACCCCAACACCCCAAGGGATACCCTCCAAAAAATCGCCCACGATTGGAAAATCCCCGAAGCCCTTACCCGCCTCCAAGACCCCTAAACCCCCTCCCTTTCTTGCCAAGTGGTAGAATCCGAGGTATGGCGGCGGAGGTTCGTAGCAAAGTGGGCGAGGTTTTGCGTCAGCGGCGGAAGGAGCTGGGGTTGACGCTGGGGCAGGTAGCCCAGGCGTTGGGGACTTCAGACGGGTATGTGTGGAAGCTAGAGCAGGGGCTTATCAATCTGGGGAACGTGCCTTACCACCGTTTGGTGGCCTTGATGAAGGTGTTTCGCTGGAGCCCCGAGGAGTTTGCCCAAGCCACCGGGGTCAAGGTGCCGGGGTTCACGGCGGAAGGTGTTCCCGGGGCGCCCCCGGTGCCTCTCCTCAAGGTCCCGTTGGTGGGGGCAGGGGCGGGCGCTGAAGCCCCGGCGTCAACCGAAGAGCCTGTAGAGTACCTGATCCTTGGCTTGCCGGAAGTGGAGGTGGACCCGAAGGATCTCAGGGCTTTGGCCTACAAGGATGGGTTTGTGGTGTACCGGGAGGGCGAGGAGCCCGAGCACGGCAAGCTGGCGGTAGCGGTGTCCAAGGAAGGCCAAAAGGTCCGCTATCCCGTGCGGTTCCTCGGGCTCAACACCCGCAAGAGCTTTGTGGTGGAAACCCTGGGGTGCCCCTCGGAAACCCGGGTCCTGGAAAAGACCGAGTGGGCGCTTCACCGAGTAGTGGGCCAGGTCAAGCTGGAGGACTAAAGGGGGAAAACCGGCGTTCGCCACAGGTCAGGCTAGGGTTGTAGGAGAAAAAGAGCCCATGGAAGAGCACAAAGGTACACCAGCGGATGCGGGCCAGGTAGCCCTAAGGTAGCCGCCAAGAGCTCCGGGAAGACCACCAGACTTTGCGCGAAGACGTTAAGCGGGAACTGAGCGAGCTGAAGCAAGAACTCAGGGAAGTCCGGTCCGATGTGAACAGCCGCATACAGCAAAGCCAAAACATTCTCCTTATCGCCCTCGGGATAGCCACACTCTGCTCGCCGCCTTCTCCCTGATGCAACGCTAAACCCACGCGCATGGAGAGACGACGGTCGTTTTTGGCCCCCCCTACCTTACATGGCATCTAGAGCTCCGTCGGCCCACTCCTGTTTCACCCTTCTAGGTGCCCTTCCAGGGGGAGGTATTCCAGTTGCACGCTAGCGCCCTTAGCGTAGACACCTTCCTCCGTGGGAACCAGGACAAGAACGGTGTAGCCCTCTCTGGCGGAAGTTTCCACGAGATCGGGGAGGACCTTTCGCACCCATCCCCGGATGGGCTCCTCCAGGTTGGGGAGCATGTTGTAGAGGGCAAGCTCCAGCTCCTCCGGGGTTTCGCCCCAAAGGACCAAGCCAGGGCCCCTTGCTCCCGTTTCCATCCGAAGCTCCGCCAGCATCTGGTCCGTTAAAGCGTCTAAGGTCATCATGTCCTACCCCCTATCGTAAAACCGAAACCCCCGTCCGAGGTCGGACGGGGGAAAACCACCGGGTCGCCGCTAGTCGGCGAACCCGGCAAGCTCAGTCCTCAGGTAATCCACCAGCTCTACCGCAAACTCCGGGGTAGCCCCGGCGATCACCTGTGCGCCCTCAACGGTCGTGTAAGGATTTATGTGTAAGGGTCCGTGTTTAATAGGGGGGCACACCTTAGCACGAGGAGGTGCCCCGTGGACCAGGATACCTTGCGGATCTTGCTGAGGGAAGCGGTGCGGGAGACAGTAGCCGAGGTTCTGCAGACGGTTCTGGAGCTGGACCGGACGGCCTTCTTGCAGGTGCACGGAGGCCGCAGGAACGGCTACTACCCCCGCAAGCTGGAGACCACCTTCGGCCAGGTGGACCTGAAGGTCCCTAGGGATCGGGAATCTCGGTATTACCCGGCTTTCCTTAAGCCCTACGTCCGCCGCCTGGTGGACGTGGGGGAAGTGGCGGTAGCCCTTTACGCCGCCGGGGTCAGTCAGCGCAAGGCGGCCGAGATACTGAGCCTGCTCTTAGGCCACCGCTACTCCCACGAGACCCTGAGCGCCCTGACGGACGAGGTCCTGGAGGCGGCAGGAGCCTTCCGCACCCGGCCTTTGCCCGAGGAGATGGCCTTCGTCTACCTGGACGGGCTTTCCCTAAAGGTCTTCAGGGAAGGAGAAGGGATCGTACGGGAAAGCGTGTATGTGGCCCTGGGCATCGCCCCTAATGGGGAGAGGCGGGTCCTGGGGTTTTGGCTGTTGCCCACGGAGAGCGCCCTGGGATGGGAGGGGGTCCTGGGGGAGCTTTGGCAGCGGGGCCTGCGGCGGGTATTGCTCTTCATCACCGACGGGCTGCCCGGGCTTCCTGAAGCGATCCGCAGGGTCTACCCTCAGGCGGAATGGCAGCGGTGCGTGGTGCACGGGGTGCGGTGGAGCCTGTCCCAGGTGCGGGCGCGGGACCGGGGCCTGCTGGCGGAGGACCTGAGGCGGGTGTACGGGGCGGAGAGCCGGGAAGAAGCTCTTGGGGCCTTGGAGGAGGTGAAGGCCGCCTGGGGTTCGCGGTACCCGGGGGTGGTGGGGCTTTGGGTACAGGATTCGGGGGCCTTCCTGCGGTTCTACGGGTACCCCAAGGTGCTTTGGCCGTACCTGCGGAGCACCAACCTGATGGAGCGGTTTATCCGGGAAGTGCGGCGGGGGACGAAGGTGCGGGACCACAAGTTTCCTAAGGAAGAGGCGGTGTACAAGCTTCTTTACCTGGAGTCGGAGAGGCAGGAAGGGAGGTGGGCAGAACGGAAACTAAAGGGGTTCTCGGAGGTGAAGGAGGTGCTGGAGAAGATGCTTCAGGAGCGGTATGCCCCCCGTACACAGACTCTTACACATAACTCTTGACACGACCCCCTCAACCGAAGCCCCCTCCATCAGGGCCTCCACGAAGGCGACACCGGTGTCGCCAAAGAGCAATTTCACCTCTTCCAGCACAGACTTCACTTTAGCCCGCAAGAGGAGTGCGTCATAGTCCATCTCCTCCGCGGGCTCCACCCCCACCTCCCGCATAAGGTCGGTGGAAAGGTGCCCAGCCGCCTCCAGGGCCTCCCGCAACTCCTTGGGAAGACCTGCCTCCTTCGCCGCTTCCTCCGGGGTCTTCTCCTTGAGAAGCCCGAAGTAGCGGCGAATGGCCTTCGCTTCCCGGTGGGAAAGCTTGAACACCCCCACTTCCTGGGCCCGAAGCTCTGCCAAGCGCTTGCGAATCTCAGGCACGAGGAAGACCAAGGGGTTCAGCTTGCCCGCCTTGAGGCGCTTGGCGATCTTTACCCCCTCAGTCAGACCCCAGGAATAGGCGTATTCGGGGTCCTTGAACCCCATCAACGCCACCTCCCAGGCGACGATGGGCTGGAGGAGGCGGATCACCTTGAACTCCCAACCCCAACCCTTCCTCTTCTCCTGCCACACCTCCTTTACCTCGGCAAAGGTGAAGGGCTTGGAAAAGCGCAGAACGGTCGCGACAACCCCCCACCAACCCCCTTCCCTCTTGAACCGGGACCCCTTGGAAACCCCAAGGGCCCAGTAAAGCTCAGAGGGGTTATACACATCCACCTCCAGGATCCACTCGTCCAGAATGGAGAGTGCATCTCCCTGGAGGTCTCGGAAGTACGCCAAATCCACCTCCTCCGCGTCCGGGTCCACGGAGGAGATGAGGGCCTTTACCACCCAGGGATCCACCCTGGTTTGGTGGGCCCAACCTTCCCTCTCCTCCTCTTCTTCCTCCCTCTTCTCCTCTTCGTACCACCTCCTCAACTCCCGGATTGCGACCGCAATCCGGGGTTCGGGGGCCTCCAGGTCCTCCCAGCGGTCCCCAGGAAGGAGCCTTGCCTGCCCCCAGGGGAGTTTCACGGTGTTCTTCTGAGCTTCCTTGGTGAGGATCTTGGCAACTCTAGCAAGTACCATCTTCCTCGCCTTGGAAGCCAGAGAGCCCACCAGGTAAACCTTCTCCCCCTTCGCCACCCTGTAGGCGGCGGCCCACAGGGCTTTCTGGGAGAGGCCAGTTCCCCCAACCCGGAAAACCCCCTCCTTCACACCCTTGGGTGAGGTGGAAACCACCACCACCCGCTCCGCCACCTCGGGAGCGAGAGAGAGCCTCACCTCTTGCCTCTCTTGCTTCCCTTGCCAGTTCCTCTGCCTCGCGAGCCGCCGGGTGGCCTCTTCCAGGGCCATGAGAACCACCCGGGCCTCGGGGGAGTTATCCCCCCTAATCGCCCACCCGCCCCCGACCCAGGCAGCGTGGGCGTCCCTGAGGAACTCCTCCTTCTCCGTGGGGTTGGCACGGAGAAGGACCCCCAGCGTCGCCAGGGCCTCCTCAGGCGTCCGGGGGGACCGCCCGAGGGCCTCCACCACCTTCGCAATCCACCTTTCCGCTCCCATAGGGCCTTCATTATACCACGGTAGTAGAGTAGACAAGGGCGGATTTGCGGTGTATAGTGAAAGTGCCACCACCTTTACCACCTCTTCCGCCCATAGTGCCTTCCGGGGTCCTTCGGGGCCCCGAAAGGTTTCTTTACGGACGTAGTGTTTCTGGGGCGCTAGTTATACGAGGCGGGGGGTTTAGTATCCTAAGCTCGTGCCCTTCTTGCTTATCGGGTTGCTCGTCGTGGTCGTGTCAAGAGTTATGTGTAAGAGTCTGTGTACGGGGGGCATACCGCTCCTGAAGCATCTTCTCCAGCACCTCCTTCACCTCCGAGAACCCCTTTAGTTTCCGTTCTGCCCACCTCCCTTCCTGCCTCTCCGACTCCAGGTAAAGAAGCTTGTACACCGCCTCTTCCTTAGGAAACTTGTGGTCCCGCACCTTCGTCCCCCGCCGCACTTCCCGGATAAACCGCTCCATCAGGTTGGTGCTCCGCAGGTACGGCCAAAGCACCTTGGGGTACCCGTAGAACCGCAGGAAGGCCCCCGAATCCTGTACCCAAAGCCCCACCACCCCCGGGTACCGCGAACCCCAGGCGGCCTTCACCTCCTCCAAGGCCCCAAGAGCTTCTTCCCGGCTCTCCGCCCCGTACACCCGCCTCAGGTCCTCCGCCAGCAGGCCCCGGTCCCGCGCCCGCACCTGGGACAGGCTCCACCGCACCCCGTGCACCACGCACCGCTGCCATTCCGCCTGAGGGTAGACCCTGCGGATCGCTTCAGGAAGCCCGGGCAGCCCGTCGGTGATGAAGAGCAATACCCGCCGCAGGCCCCGCTGCCAAAGCTCCCCCAGGACCCCCTCCCATCCCAGGGCGCTCTCCGTGGGCAACAGCCAAAACCCCAGGACCCGCCTCTCCCCATTAGGGGCGATGCCCAGGGCCACATACACGCTTTCCCGTACGATCCCTTCTCCTTCCCTGAAGACCTTTAGGGAAAGCCCGTCCAGGTAGACGAAGGCCATCTCCTCGGGCAAAGGCCGGGTGCGGAAGGCTCCTGCCGCCTCCAGGACCTCGTCCGTCAGGGCGCTCAGGGTCTCGTGGGAGTAGCGGTGGCCTAAGAGCAGGCTCAGTATCTCGGCCGCCTTGCGCTGACTGACCCCGGCGGCGTAAAGGGCTACCGCCACTTCCCCCACGTCCACCAGGCGGCGGACGTAGGGCTTAAGGAAAGCCGGGTAATACCGAGATTCCCGATCCCTAGGGACCTTCAGGTCCACCTGGCCGAAGGTGGTCTCCAGCTTGCGGGGGTAGTAGCCGTTCCTGCGGCCTCCGTGCACCTGCAAGAAGGCCGTCCGGTCCAGCTCCAGAACCGTCTGCAGAACCTCGGCTACTGTCTCCCGCACCGCTTCCCTCAGCAAGATCCGCAAGGTATCCTGGTCCACGGGGCACCTCCTCGTGCTAAGGTGTGCCCCCCTATTAAACACGGACCCCTCAGTACACGTCAAAACGTGGGACCACCCCTTTAGGATGGACCTGCGCCCACGTGGATGGGCAGGTACCCATAGGAGGTGGTCCCCATGGAACAGCTTACCCCACTCATCAACGCCTTGAAGCGATACTGGAAGGCCGACCTCAGGCGCCTCACCTTCCTGGCCGCCCTGGTGATGGCTCTGGTCACCGCCCGCACCACAAGCGGCCCCAGACTCGCTCTTTCCCTCGGCTCCATAGCCAGCCCTGACCCCCGCTCCGCCTACCGAAGGTTCCAGCGGTTCTTGGCCTGGCCGGGGCTGGACGGGGAGGGCTATGCCCGCTTCATCTTCGCCCTCCTCCGACCCCAAGGGCTCCTCCTGGTCATGGACCGGACCGAGTGGGAGCTGGGGAAGAGCAAGGTCAACCTCCTGATGCTGGCCTTCCTGTACCAAGGCCTGGCCGTCCCCCTGTTCTGGAGCTTCCTTCCCCACGACGGCAACTCCTCCACCCCCGAACGCATCGCCCTGATGGAGAGGGCCTTGGCTTTCCTGAGGGCCCACTTCCCCCACCTCCGGGTGGAGGGGTTCCTGGCGGATCGGGAGTTCATAGGGGAGGCGTGGTTCCGGTACCTGGAGGAGAAGGGCATCCCCCGGTGCATCCGAATCAAGGCCAACACCCGGATGTGGCGGTTGGGCTCGGGCCCTCGGGCCTGGGAGCTCTTTGCCTCCCTGAAGGTGGGAGAGAGCCGGGTGCCCAGGCGGCGGTACTGGGTCTACGGGCGGCGCATGTGGGTGGTGGGGTTGCGCCTTGGGGTCCGGGAGTGGCTGATTGTGGCTACGGACCTGGACCCTCACCGGGTGCTGGAGGTGTACGGGCTCAGGTGGGGGATAGAGCGGCTCTTTGGGGCCCTGAAGGGGCGGGGATTTGACCTGGAGGCCACGCACGTGACGCGGGGGGAGAGGCTTTCGCGGCTTTTGGTCCCCTTGAGCCTGGCCTTCGTGTGGGCGTTTCGGACGGGGCTTGTGCTGCACCGGGTGCGTCCGGTGAGGCCCAAGAAGCACGGGAGGCTGGGACAGAGCCTCTTCCGGGCGGGGCTGGACCTGCTCACCCTTTGGGCGCTTGCCCTCTGGGGTGCAGGGGGAGGAAGGCGCGGAAGTCCCTTGGGGTTATGCCCTATGGAGGTTTTGACGTGTACATAGCACGGACCCTTACACATAAATCCTTACACGACCCCGGCTTCTGGTGGACCTCTACCTGCTGAGGCGCCTGCCTCCCCTTGAGGCCAACGTGGGGAAGCGCCTGGTGAAAAGCTCCAAGCTCTACCTGCGGGACAGCGGTCTGGTCCACGCCCTGCTGGGGATCCAAAGCCTCGAGGACCTCCTGGCCCATCCAGTGGTGGGCGGAAGCTACGAGGGCTTTGTGGTGGAGAACCTGGTCCGGGTCCTGCCCGATGGGGGAGAGGCCTTCTTCTACCGCACCCGGGCGGGGGCCATCTGGCTTGCGAGGAAGCGGCGGAAGATCAGGTCATAAAGCCGCCCGTGGGCCTCGGAAAGGGGCAGGGCCTGGAAAAGCCCTGCCTCCTCCAGGTCCTCGGGCCAGAGGGGGCGGGTGGGGCGGATGGCCTCGTGGGCGCCGCCCTCCCCCCAGGGCCGGGGGCGGGCGTACTCCGGGCCGAAGCGGGCCTCGATGAGCCTCCGGGCCAAGGCCATGCCCTCCGGGGCCACCCGGGTGGCGTCGGTGCGGTGGTAGGTGATGAGGCCCGCCTCAAAGAGGTCCTGGGCCAGGGCCATGGCCTCCGGCACGCGGAACCCCTCCCGGGAGGCGTCGGCGAGGAGGGCGTCCGTGGTGTAGGGGGGAAGGGGGTTTTGCTCCCGCTCTGCCTCCTCCAGGACCTCCAGGAGGAGGACCCTCTCCCTGACCTCGTCGGGAAAGCGTAAGGCAAGGCCCCGAAGGGCCACCTCGGTGAAGGGCAGGCGGGTTCGGGCCTCCCGCTCCCGGGCGATGACCCAGCCCAGGACCGGCGTCTGGACGCGCCCGGCGGAGAGGCCCCGGCGGCCAAGAAGCCTTTGCAGGTCCTCCGAGAGGGCGAAGCCGACCCAGCGGTCGGCGATCCTGCGGACCATCTGGGCCTCCACCAGGTCCTCCTTCACCTCCTGGGGATGCCTCAGGGCCTCGAGGAAGGCCCGGGGGGTGACGGCGTGGAACTCGCCCCGCACCACCTCCCTCCCGAAGGCGCGGAGGGCGAGGTAGACGTCATAGGCGATCTTCTCCCCTTCGGTGTCGGGGTCGGTGGCGAGGAGGAAGTCCTGGGCCTCCAGGGCCAGGCTCCTTAGCGCCTGGAGGGCCCGGTCGCGGTCGGGCTGGCTCTCCGTCCCGTCGGGGCACAAGGGGTCCGGGACGCTCCCCTCGGGGCAGGCCCGCAAGGGGTGTAGGCGGGGGCCGTCTCCACCCCGTAAAGCCCGCCCCGGAGGGCGAGGTCGGTGACGTGGCCCCGGGTGGCGGTGACCACCAGGTACCCCTCCTCGGCGAGGGCCTCGTAGACCACGAGGCCGGGGAGGTAGCGGCGCATGGGCCGGCCGAAGAAGCCGGCCAGGGTGCGGGCCTTGTTGGGCGACTCCACCACCACCACCCGCTCGGGCAGGGCAAGGCTACCCCGCTCCCCCGGGCGAGCCGTTCCCGGTCCTCGTCCACGCGCTTCAAGAGGGCCTCGAGGTCCGCCTCGGCCACGGGGAGAGGCGGCGCCTCCAGGAGGTAGCCGAGCCGGCGCACGAGGGCGGTGAAGGCCTTCCTGTCCTCGGCGAGGAGGAGGGCGAGGCCCTGGGTGAGCCCCGCCGGGGTGAGGCGGCTCGTCCGCCCCGAGGCCTGGAGGTAGCCGGTGACGTCGGCGAAGACCAGGACGGGCTTTTCCCCCACGAAGGTGAGCCCCACCTCGGGGCTTTCCGCCACGCGGGCGCGGAAGGCGGGGTCGGCGAGCCGCTCCAGGAGGGCTTCTCGCAGGGGGGCGACCTCCTTCTCCTGGAGCCCGGGCCTCCTGGCGAGGCTTCGGACCAGGGCCTTAAGCCTTGGGTCCTCCAGGAGGGGCAAAAGGGCAGGGGGTTGCGCCAGGAGGCGAACCCCACGAGGAGGTCTGCCTCGCCCCGCCGGAAGGCCTCGAGCGCCTCGGGCTCCAGATAGGCCTTGGCCCTGAGGCCCCGGGCCCGGAGGAAGCGGGCGAGGTCCAGGGCGGCCTCCTTCGGCAGGTCCCCGGGGAGGAAGAAAAGCCCCCCCTTTCCAAGCCGCCCCGCCCACTCCGCCCCCCTGGCCCAGAGTTCCTCCTGGGAGAGCCCGAAGGCCTCCTCGTAGAGGTCGGCTACCTTGCGCAGGGCGAAGCTCGGCGTGCCCACCTCAAAGCCCAAAAGCTCGCGGAAGAGGTGGACCCGCGGCGAGTGCGGCCTTGCGGTGGCGCTCGCCACGGCGAGGACCCCCCGGGCCTTCCCCCTCAGCCTTTCGGCCCTCCGCTCGGCCTCCTCAGGGTGCCTCCTCCGGAGCCGGATGAGGGCGAGGCCCTTCTCCACGTCCTCGGGGGCGAAGCCCAGAAGCCCCAGGACCCGGTCCACGTTCCGCGCCGACTTGAGGAGGCTGGCCACATCGTCCACGAAGAGGAAGTCCACGGGCCGGGGGAGCCGGGCGTGGTTTTTGTGGAGGAAGGCCACGGTGAAGAGGCCGATGGGGCGGCCGCCCTCGAGGAGGGCTTCCTTCTCCCGGGGCTTCCCGGTGTAGGCGGCGAAGGGGGCGCCCAGGGCCCGAAGCCGCTCCGCCGCCTGGGCCACGAGGAGGCGGGTGGGGAAGACGAGGTAGCTCCGCCGCCCCTCCCTGGCAAGCCAGCTGGCGGTGAGGAGGCCGAAGGTGGTCTTGCCGATCCCCGTGGGGGCGAGCATGGCGAAGGAGCGCCCCTGCACCACCCGCGCGGCCCAGGCCCGCTGCCGCGGCCAGGGCGGGGCGCCCACCTGGGCCGTAAAGAAGCGGGTCCAGTCGGCGAGGGCCTTTTCCTGGGCGGCGAAATGGGCGAGCGCCCCGGGGAGGGGAGGCTTTTGGGGGTCCGGCTGGCAGCGGGCGCAGGCAAGCCCCGCAGCGAGGCGCTCGCTTTCCGCCTCGCCGCCGCAGTTTGGGCAGTAGGCGGCGTAGCGCGTCGGGATCACGGCCCCATCCTAACCCGAAAAGCCCTGGGCCCCTCGGCGAAGGGCACGGGCCGGCGGTGGCCGGGGAGGAAGGCGAGCTCCTTTTGCGCCAGGTCCTGGAGACGGGGACCGAGGTCTTGCAGATCCTGCTGGACGCCGACCAGGGCCATGCCCAGGGGGCGTACTCTGCGGCCTTCTTTCGGGAACACGGCGGCCGCAAGAACGGCCACTACCCCCGTAGGCTGGAAACCGCCTTCGGCCAGGTGGCCCTTCGGGGCGGCGAACTTCAGGAAGCGCTTGTTGAGGTCCACCTCGCCAAAGAGGGAGAGCCCCGGTACCTGCTCCACGGGCAGGTGGCGCTTGTGCTCGGGGGTTTCCAGGACGATGGTGTTGGCCATCCCGCCAAGCCTTCCCGAGGAGAAGGCGTAGACCGGCTTAACCATCCCCTTCTTCCACGAAGTGGAGCTCAAAGTAGGCGCACCCCGAGCAGGCTGGGATCCTCTTGGGGGGTGGAGGGGTGGGCCTTTACAAGAGCGCCCGAAGGGCCTCCTCCTTGCGCATCCCGTGGGCCAGGGCATGGGGCGGGCTTTTCCGGTAGCGCTGGGCCTCGTGGAAGCCCTGTGCCTCCAGGTCCTGGTAGAGGCTTCCCCCCAGGGCCACGTCCCTTCCCTGGAGGCCCTTTTCCGCCGCATACCGGGCCAGGAAAGGTTCTTGGGTGTCCCGCTCGGGGCTCACCCCCGGAGCCTCGGGTGGGACCCCTCCCCGAAGCAGGCGGGATCGGTATCCCCGCCCCCCGGGAGGCGGAAAGGATCCGCTCCAGCCTCTCCGGGGGTTAGGGGGACGTGGGCGAGGCCCCTATGGGAGAGGGCCTTTAGGTGGGGCTAAAAAACGCCCCGAAGAACCTTCGGGCCAGGGAGGATCTGGGTGGCCCCGCCGATAAGGCGCATGGACCCCGCAGCACAACCCCAAGGTCCCTAGCCACCGGAATGGACCAGGTAGCGGAAGCCCAAAGGCGGGATCTCCACCTGGTTCCGGTAGGTGCGCCCCTCGAGGGGGTCCCGCCAGCCCCCCGGGGGCAGGGGCAGGGGGGTGGCCTCGAGGCCGCTATTGAAGGCCGCTAACACCTCGCCTTCTCCCGGCTCCCCGCGGAAGAAGGCGAGCAGGTGGCCTTCCCCCAGATACCCCCGGAAGACCGCGCTCCTCAGGGCGGGGAGCTCCCGGCGCAGCCAGGCCAGCCCTTGGTAAAAGGCCAGGGTCTCCCCGCGGCACCGGTCCCACTGAAAGGGGTACCGTTGGAGGTCGTACGGGGGCTTATCGGGTTTCTCCCCGGTAAAGCCGCACTCGTCCCCCTGGAAGGTCACCGGGACCCCGGGGAGGGCGTAGAGGAGTGCTGCGGCCAACCGCTGCCGGGCCCGGGCCTCGGAGCTTGGGACGTCCCCTAGGCCCCCGCCCCCCACCTCGGTGAGGAGCCGGGCGGTGTCGTGGGAGCTGATCAGGTTGAAGCCCATGCCGGCCACGGCCTCGGGGTAGAGGGCGTAGGTCCGGGAGAGGTCGGCCAAGGCCCGCCTCCCGTTGTAAAGGGCCAGGCTTCCCCCCTTGGCGAAGCGCAACAGGATGTCCCGGCCGATGGCGTAGTTCATCAGGGAGTCAAACTCGTCTCCCTGGAGCCAGCTTGTATCGCGCTGCCAGATCTCGCCCACCAGGTAGGCCTCGGGCTTGAGCCCCTTGAGTTCGGTCCGGAGGGCCTTGAAGAAGCCGTGGGCATCCAGGAGATCCCCGGGCACGTCCACCCGCACGCCGTCAAAGCCGAAGCGCAGCCAGTACTTGGCGACCTCTAGGAGGTAGCGCCGGACCCCCGGGTTGGCGGTGTTGAGCTTCGGCAGGTTCCCCAGGCCCCACCAGCCCTCGTAGGCCTGGCCGTCCCCCGGCGTGAAGGGCCAGCGCTTGATGAAGTACCAGTTCCAGTAGGGGGAAGCCGGCCCCCGCCGGACCACGTCCTGGAAGGCCCAGAAGCCCAGGCCGGTGTGGTTGGGTACGAAGTCAAAGATGACCCGCATTCCCCGGCGGTAGGCCTCCTCCAAAAGTTTCTTCAGGAGGGTCTTGTCGCCGAACTTGGGCGAGACCTCGAGGTGGTCGTGGGTGTCGTAACCGTGGGCCGAGCCCGAGTCAAAGAGGGGGTTGAAGTAGATCAGGCGCACCCCCAGGGCCTCGAGGTGGGGAAGCTTGGCCAGGACGCCCCCGAAGTACTGGTGGCAGCAGTGGTGCACGCTGGGCGGGTCGGTCCAGCCCGAGAGGTGGGGTCCCATCTCTCCCGAGCGCTGCCAGACCAGGTTGAACCGGTACTCATCGGTCTCCAGGGCCTTGGCGTCGTTGCTGGGGTCGCCGTTGAAGAAGCGCTCCGGGAAGATCTGGTAGCCCACCCCTTCCCCTACCCAGGGCACCTCGGCAAAGGGGTGCGCAGGGGGGGTAAAGGGGCCAAAGACCTCTTCCCGGCCGTCTTGGGTCTGGACCCGGATGCGGTACGCCCCGATCCCAGGCGCCACCGCCACGCGCCACACCTCGGTTCCCGGGAAAAAGAGCTGGCGGTGCATGGGGAACCGCTCCCCGCCCGCCTCCAGCCAGGCCTTGGCGACCGCCCCTTCGGCGGCGCTAAAGCGAAGGGAAAGCTTCCCGTCCGCCAGGGAGAGGTAGCGGGCCTCCTTGGGGTCATGGGCGAACTCCAGGGCCACCGGCCCGCCCGGGGCTACTGGGGCCTGGACCACGATCACCGCGTTCTGGCCGCCGAAGCCGTCGTCCACACAACCTGCGGCCGTGGGGTCCACCATTGGGGTGCCGAAGGTGGGGTCGTGGCACATGTCCTTGGGCCACTGGCCGTTGATAAAGAACTTGTACTGGTACTCGCCTGGTTCCAGATCCAAGGTTATCGTCCAGGAGCCGTCCTCCTTCTTCATGGGGGTCTCGCCCCAGCCGTTGAACGAGCCCCTGAGGCTCACTGTCCGCACCTCCAACCCCGGGGGCGGGGTGTAGCGGAAGGTGACCGGCACCCCCAAGGCCCAGCCGAGGACCGCTACCAGCGCCAGGATTCGCCGCATATTCCCTCCTGTAAAAGCGCTTCCATACTACCCCAAACTGGGGAAAGCCTCAGCTCAGAGCCGCGAAAAAGCTTGTACACCCCTTCTCCGGAGGAGAGGCCGGTGAAGGGCTAGACGTGCGGGGGGATGTGAACGTGGTGTAGAATGGCTTATATGGTGAAAAAGGTCCACTCCACCACACTAACGGTTGATGCCCAGGGAAGGGTGCTCCTCCCGAGCCCCTTGCGCCGGGCCTTGGGCCTTAGGCCGGGGACCCGGTTGGTGGCCTTGGTGGAGGAGGGTCGCCTGGTGCTGGAACCTTGGGAACGGGTGGAGGAAGCGCTTTGGGAGGAGCTTTCCGACATCAAGGAAAGCCTTACCGAGGAGCTTTTGCGGGAACGGCGCTTGGAGGCCGAGCGGGATGCCTGAGGAAAAACTTCTGGACGCTTCCGCCTTGCTCGCCTACCTGCAAAGGGAGTCCGGCTTCGAGGTGGTGCGCCAGGCCTTGCGTGAGGGGGCGGCCATCAGCGCAGTGAACCTGGCCGAGGTGGTGGGCAAGCTCAAGGGTAGAGGAAAAGACGCGGACCGGATTGTGGCCAGACTGCTGGCGATGGGCCTCGAGGTGGTGCCCTTCACCTTGGAGGAAGCCCTCGAGGCGGGTGCCCTGGATCCCTTGACCCGCCCCTTGGGGTTTTCCCTTGGGGACCGGGCCTGCTTGGCCACGGGGAAGGTGCGGGGCTTGGAGATCCTCACCACAGACCGGGCCTGGAGCCAGATCCCGGGCGTGCGGATACGGGTGGTGCGCTAAGCTCAGGGGGCCGGATCAAACACCTCCCTCATGACCCAGCTGGAGGCGGCCACGGGAAGTCTTTTCCCCAAGGCGCCCCAGTGGGGCAACTACCTGGACATCTGGCGCGTCCTGCCCTTCTTTCACTACTTGAAAAACTCCTTCCTGGTCTGCTCCCTGACCACGGCCTTCGCCCTGGCCGTGGCCACCTTCGCCGGGTACGCCCTCGCCCGGTTCCGCTTCCCCGGAGCGGAGCTTTTTGGGGGAAGCGTCCTCGTGACCCAGGTGATCCCCGGAATCCTCTTCCTGATCCCCATCTACATCATGTACATCTACGTGCAGAACTGGGTCCGCTCCGCTTTGGGCCTCGAGGTGCGCCTCGTGGGCAGCTACGGGGGGCTTGTCTTCACCTACACCGCCTTCTTCGTTCCCCTGAGCATCTGGATCCTCAGGGGCTTCTTCGCCTCCATTCCCAAGGAGCTGGAGGAGGCGGCCATGGTGGACGGGGCCACGCCCTTCCAGGCCTTCCACCGGGTGATCCTGCCCCTGGCCCTCCCGGGCCTCGCGGCCACGGCCGTCTACATCTTCCTCACCGCCTGGGACGAGCTCCTCTTCGCCCAGGTCCTCACCACCGAGGCCACCGCCACCATTCCCGTGGGCATCCGCAACTTCGTGGGCAACTACCAGAACCGCTACGACCTGGTCATGGCCGCCGCCACGGTGGCCACGCTGCCCGTCCTCGTCCTCTTCTTCTTCGCGCAGCGCCAGCTCATCCAAGGCCTCACCGCCGGGTCGGTGAAGGGCTAGGCGTTGGGAGGAGGAACGCGCATGGCCGAGAACGCCGAAAAGTTTCTGTGGGGGGTAGCCACCAGCGCCTACCAGATCGAGGGGGCCACCCAGGAGGACGGGCGGGGGCCTTCCATCTGGGACACCTTCGCCCGCCGCCCGGGGGCCATCCGGGACGGAAGCACAGGGGAGCCCGCCTGCGACCACTACCACCGCTACGAGGAGGACATTGCCCTTATGCAATCCCTCGGGGTGGGGGTCTATCGCTTCTCCGTGGCCTGGCCTCGGATCCTCCCCGAGGGCCGGGGGCGGATCAACCCCAAGGGCCTCGCCTTTTACGACCGCCTGGTGGACCGGCTTCTCGCGGCGGGGATCACGCCCTTCCTCACCCTCTACCACTGGGACCTGCCCCAGGCGTCGAGGACCGGGGCGGTTGGCGGAGCCGGGAGACCGCCTTCGCCTTCGCCGAGTACGCCGAGGCGGTGGCCCGGGCCCTCGCCGACCGGGTGCCCTTCCTCGCCACCCTGAACGAGCCCTGGTGCTCGGCCTTCCTCGGGCACTGGACGGGGGAACACGCCCCCGGCCTCAGGAACCTGGAGGCGGCCCTTCGCGCCGCCCACCACCTCCTCCTGGGGCACGGCCTCGCCGTGGAGGCCTTGAGGGCCGCGGGGGCGAAGCGGGTGGGGATCGTCCTCAACTTCGCCCCGGTGTACGGCGAGGACCCCGAGGCGGTGGACGTGGCTGACCGCTACCACAACCGCTACTTCCTGGACCCCATCCTGGGCAGGGGGTATCCCGAAAGCCCCTTTCAAGACCCCCCGCCCACTCCCAACCTCTCCCGTGACCTGGAGCTCGTCGCAAGGCCCCTGGACTTCCTAGGGGTGAACTACTACGCCCCCGTCCGCGTGGCCCCGGGGACGGGGCCTTTGCCCGTGCGCTACCTTCCCCCGGAGGGGCCGGTCACGGCCATGGGGTGGGAGGTCTACCCCGAGGGGCTTTACCACCTCTTGAAGCACCTCGGCCGGGAGGTGCCCTGGCCCCTTTACATCACGGAAAACGGGGCCGCCTACCCCGACCTCTGGACGGGAGAGGCCGTCGTGGAGGACCCCGAGCGGGTGGCCTACCTCGAGGCCCACGTGGAGGCCGCCTGGCGGGCCCTCTTCACCCTTTACGCCACCGCCACCCCCTTTGACCGGCCCTGGGAGGCCCGTTACCTCCTGGAGCCCACGGGCTTCGTCCCTTACCGCCTCTTCACCCGTTTCATGCGCCAGTTCGCCGTCTACACCCGGGAGCGGTACCGGGGAGGGAGGTCGTGTCAAGAGTTATGTGTAAGAGTCTGTGTACGGGGGGCATACCGCTCCTGAAGCATCTTCTCCAGCACCTCCTTCACCTCCGAGAACCCCTTTAGTTTCCGTTCTGCCCACCTCCCTTCCTGCCTCTCCGACTCCAGGTAAAGAAGCTTGTACACCGCCTCTTCCTTAGGAAACTTGTGGTCCCGCACCTTCGTCCCCCGCCGCACTTCCCGGATAAACCGCTCCATCAGGTTGGTGCTCCGCAGGTACGGCCAAAGCACCTTGGGGTACCCGTAGAACCGCAGGAAGGCCCCCGAATCCTGTACCCAAAGCCCCACCACCCCCGGGTACCGCGAACCCCAGGCGGCCTTCACCTCCTCCAAGGCCCCAAGAGCTTCTTCCCGGCTCTCCGCCCCGTACACCCGCCTCAGGTCCTCCGCCAGCAGGCCCCGGTCCCGCGCCCGCACCTGGGACAGGCTCCACCGCACCCCGTGCACCACGCACCGCTGCCATTCCGCCTGAGGGTAGACCCTGCGGATCGCTTCAGGAAGCCCGGGCAGCCCGTCGGTGATGAAGAGCAATACCCGCCGCAGGCCCCGCTGCCAAAGCTCCCCCAGGACCCCCTCCCATCCCAGGGCGCTCTCCGTGGGCAACAGCCAAAACCCCAGGACCCGCCTCTCCCCATTAGGGGCGATGCCCAGGGCCACATACACGCTTTCCCGTACGATCCCTTCTCCTTCCCTGAAGACCTTTAGGGAAAGCCCGTCCAGGTAGACGAAGGCCATCTCCTCGGGCAAAGGCCGGGTGCGGAAGGCTCCTGCCGCCTCCAGGACCTCGTCCGTCAGGGCGCTCAGGGTCTCGTGGGAGTAGCGGTGGCCTAAGAGCAGGCTCAGTATCTCGGCCGCCTTGCGCTGACTGACCCCGGCGGCGTAAAGGGCTACCGCCACTTCCCCCACGTCCACCAGGCGGCGGACGTAGGGCTTAAGGAAAGCCGGGTAATACCGAGATTCCCGATCCCTAGGGACCTTCAGGTCCACCTGGCCGAAGGTGGTCTCCAGCTTGCGGGGGTAGTAGCCGTTCCTGCGGCCTCCGTGCACCTGCAAGAAGGCCGTCCGGTCCAGCTCCAGAACCGTCTGCAGAACCTCGGCTACTGTCTCCCGCACCGCTTCCCTCAGCAAGATCCGCAAGGTATCCTGGTCCACGGGGCACCTCCTCGTGCTAAGGTGTGCCCCCCTATTAAACACGGACCCTTACACATAAATCCTTACACGACCGGGAGGGAGGGAGTTCTACTTCGCGGGGGGGATTGAGGACCTAGCCCGCTTCCACGGGTACCTCCGGGACCGCAACCTCCTCACCAAGCGCCTCTTCCGCCCCCCAGAGGGCCTGGTGGCCTACGAGGTCCCCCTCCTGGAGGTCCCCGAGGAGGCGAAGGCCCTCCTGGCGGAGGTGCGGAGGCGGCTCAAGGCGGCGGCCTACCGGGCCCCCCAGGAGGAGCGGGGGATCGTCATGGCCCAGCGCACCCTCCTCTCCCGGGCCATCCTGGAGAGGATCAAGCTGAGGGCGGCCCTTCCCCTGGTGGCCGGCCTCCTGGAGGAGGGGTGGCACGTCCTGCTCTTCGTCCAGTACCGCTCGGACAAGACCCTGGACCTCACGAGCCCCGAGGCGGTGGAGGCCTTCCTCCAGGACGCCGAGGAGAGGGGGCTCAAGGGGGCCCTCCACCGCCACCTGGCCCCGGCCCTGAAGGGCCTCGGGCTCACCCTCCCCTCCCCCGTGGCGATGGTCCGGGAGGCCTTCGGAGGGCTGGGAGAGGACCTCGCCTTCTACACCGGGGCGGAGACGGGAAGCGCCCTCAGGAGGACCAAGGCGGCCTGGGACGAGGGGAGGGTGCGCCTCCTCCTGGCCACCGCGGGCAAGGGGGGTGTGGGCCTCTCCTTCCACGACACCACGGGGAAGAGACCTACGGCCCAGATCGTCCTCACCCTGCCCTGGACGGCCACGGGGCTGGACCAGGTCCTGGGCCGGGTGGTGCGCCTTGGAATGAAGAGCCCCGTGCGGATCCTCTTCCCTGCGGCCCCGGTGCCCTTTGAGCAGCAGCTTGCGGCCACGGTGGCCCAGAGCCTGAGGACCCTGGGGTACGCGGTGCGAGGGGGCGAGGGGGTGGTGCCGGAGCGGGTGGTGGAGGCCTTCCTCTACGACCTGGCGGCGGTGGACCTGATGGGCTTCCTCAGGCTTTTAGAGGCGGAGGAAAGCCTGTCCAAGGCCCCCCGGGAGGAGGAGGCCTCTTCCCTGGAGGTGCCGCTTCCGCCCTCGGGGTGAAGGGGAGCCTAAAACTGTAGGGTGAAGGGGGTCCCGGAGGCCTCCAGGGAGTAGACCCCTTCCCTTCGGGGGTGCCCTTTCCAGCTCTTTTGGTGGGGGGCCCGGGCTCAAGCTACCCGGCCCAGAGCCGTGGGCACCAGGTCCCTCCCACCACCACAAACTGAGGGGATACGCCCAAACCCCCACGCCAAAGCGGCTCAGGAATCCTCCCGCCGTTTTCCCGAGACTCCGTTCCCCCTCCGCCCATCTGCGCCCTTCCAAGGTAGTGTTACCCCCCACCCCCATGGGTAGGGCCGGTCCACCCGGGCCTCAGGGGAGGGTCAGCCTTGCGGGAAACAAGCTTAGCGATAAGACCAAGCCCTCTTCGCACCGGCTAGGAGGCTCTCCCCATGGCCTCTACCTCCTCCAGGCGCCTGGGATGGAGCGGGCCAAGGGCGAAGAGGTAGAAGGCCAGGAAGGAGGCCAGGGCCACCCGCAAGGGCAGGGTCACGCCGATCCCCCCCAGGACCCCCGAGAGGGTTCCCCCTAAGGCGCCCGCCCCGTAGATCAGGGCCCGCAGGGCGGCCAGGCTCCCCGCCAGGGCCTCCTCGGGCAGCAACCACCCCCGCACGGCCCGCAGGTGGACGCCCGTGACCCCGACGGCAAACCCATAGAGCAGGCCCCCCGCGAGGAAAGGAGGGAACGGAAGGGCCAGGAGGAGGAGGGCCCTCACCGGGTCTCCCCGGTCCAGCCGGGGGCTCAGGAGGAGCAAAGGGCCTAGGGTGAAGTACCCGAGGGCAGCGAAGAGGCCTACCCAGAAGGCCTCCCCCGTGCGGGCCACCTCCAGGCTCAAGGCGCTGAAGCCCAGGGCGGCCCCCAGGTCGCCCAGGGCCTCGGAAAGAAAGGCCAGTTTCCAGACCGGGTTCAAGCCTCTAGAGCGAACCCTTCCACCATCCAGATGACCCCACCTGTAATGGAGCAGGCATGGCAAAGGGGCGCACGTACACCCGCCGCGTCCGGCCGCCGACCCTGACCTCTTGCACCTCCTTGAGCATCGCCATTCACCCCCTTACGGGTTAGCCCCAGAGTAGCAGCAGGGGAATACCGCCCGTGGAGCCCAGGAGGGCCTCACCCACGCCCCTCGGCGTCACCACGAGGGGAGAGAACCCTTTGGGAGAGGCGGAGGAGAGGGGGAAAGAGAAGGGAGGCCAGGAGGAAAACGCTCCCAAAGGCCACGAAGGCCCCCCTGGGCCCCAGGAGGTCCCCAAGCCCCCCGCCCAAGGGGGAGCCCAGGACCCGGGCCGTCTGGGTGAGGACGTTGACGTAGGCAAAGAGGCCCACCAGGGTCTCCGGGGGGGCAAGCCGCTGGAGGAAGGTCCGGAAGGCGATCCGGGCCACGGAAACCCCCGCCCCCGAGACCAAAGACCCGAGGAGGAGGTGGGGGTAAGGGAGGAGGCCGTTCCCCAGGTTGCCCAGGCCCAGGAGGCCAAGCCCCCCGAGGAGGCCAAGGACCGGGGGGAGGGAGACGCGGGTAAGGGCCTGGGCCACAAGGAAGCCCCCCAGGCTAAAGCCCGCCCAGGCGATACCTAGCCCCTCGGGCCGCTTGAGGTCGTGGAAGAGAAGAGCGGTGAGGACCCCGCCCCCCGTGAGGGCCAGGGCAGGGAGAAGGGCAGGTAGAGCAACGGGGAGGAGAACACCCAAGGGTACACCCCCAAAGGCCTTCCGCCTCCCTTCGGAAGGGCCTAGGGGAGGAGGGGCCTTCAGGCCCAGGAGGAGGACCAGGGCCACCCCCAGAGGAAGGGCGAAGAGGGGAAGGGCGTAGGGCCCCAGGCGGTCCACGGCAAAGCCCCCTATGAGGGGGGCCAGGACCAGGCCCAAGGTATTGGCCATTTCCCAGCGGGCGTTGGCCTGGGACAGGGCCTCCTTAGGGAAGAGGCGGGGCAGGGCGCTTCCCAGTAAAACGCCGTAGATGGCCAGAGCAGCCGTAAGGAAGAGGAAGAGGGCGAGCAAGGCGGCGTAAAGGAGAAGAAAGGTGCTAAGGCCAGGGCTTCCCAGGGCGAGGAGGGCCGCTACCCCAAGGCCAAAGGCGAGGAGGCGGAGCACCATTTGGGGCCTGGTCTCAAGCCAGGATTGGAGGAGAAAGGGGGTCAGGATGCTCGCTAAGGCTTGAACCAGGGTGAGGACCGAAGTTTGTAGCCCCGAGGCTCCCGCTTCCAGGAACCGCCATAGGCCCGCCACCACCAGGCCCTGGCCGGTCAGGGTTAGAAGGAAGGCGAGGAGGAAGAAGGAGAAGGTACCCGAGGGCGGAGTTAAATCCTTAGCCATGCTGGGACGCTGAGCCATCAGCTAGAGGGATTTCGCTGGTGTAATTGGGGATAGTCCGAATGTCCACGGCATCAAAGAAGTTCGGTTGAACAGGTATTTTCCGTAGCTCTTGCAGTAGAGGCGAATTCTCCCAAATGTCGGCTAAAGTGCTCGTTAGAAGGTTGCCGAAGAACGAATACCTGGGCCGCCACTCACGCAATTTGGCAGAAACGTAGACATTACCCCTCGGATCTACGCGAAGAGCACGATTACCCCTAGAGGTAAGCCATATCTGATCGCGGGCCGGGTTTTCCGATCTAAGTTCTCTAGAAAGCTTATACCACAGCCTTTGGTGGGGCTTAATCGCACCTAATCTAACCATGTCCATGTATTCCCCTACAGCGAAGTCCCACTCTTCCTGGCTAAGAACGAGATGATTCAAGCTTGCCCCGCGCCCTGCGGGATACATGGGCGCAATCCCATACATAGCGTTGTTTTGTGTTGCGATTTCACCTATCTTTCTAATCTCAGTGTAGTTCTTCTTGTGAACTACCGTGAAGACAGCCAGAGGGATACCGGCTTTGGCAATGAGACTTATCTGCCGCAAGGTAGTCTTAAATCCCCCCTTACCCCGAAGCAAATCGTGGCTATCCGGACTAGATCCGTCTAAAGTGGTACCCACGAAGTTCAGATTTTTTGTGGACGCAATCTTATCTAAGTCGCTATCTCGCAACACGGACAAGTCGGTGTTAACTTGAACGCTAAACCCTAGCTCGTCCGCTAGGCGGATGATCTCCAATCCATCTGGCCTACTCAGTGGATCACCTCCTGTGAATTCAAGGTAGAAGACCCCTTCCTTTCTTATGGAATCCAAGATATATCCCCACTCATCGAAAGTCAGCTCTTCCCGAAGAGGTATTTTGGGTTCAGGGCCGGATTCGTATGCACAGTATGCACAACGCCTATAGCACCTATTCGTGAGCTCGATTTCCATGGATAGAGGCCTATAGTACCGGTCATCGGAGAAGTGTTGATCGTCTAGGAACAAAGCTTTAGATTCCAGCCCTTCTTGAGAAGGGCGAAGGTATCCCTCGGCAATCAAGTAAAGGATTAAATGCCCCGCTGCCTCTACAAATCCCTTGGTAATTTCACTTAAGCCTCCTTCTTTGAGAACTTGCTTGAGGGCCAGCGATGGCCTAGTAGCAACTACAAAGGATCTAACAAGGTCGAAGGCTTCCTGATTGAGAAAAATGCCCCTCTTAAAGCCGTAGAGTATTCCCCCGAACCGCTCTCTGCGTAGGACAACGCTAGCGTCGCTGGCAAGGACAAGGGGCACGTCTTCGACCCAAAGCCTTTCGTATTCCGAGCCTAATCCTTCTTCGAGGTCCTCCTCGTAAGCCAATATAAAATTGCCTGTATCAATGGCAACCATCAGGAAATCATGCTGCTGGCCTACGACCTTTGGAAGTTGTAAACCCCTCTCGTGCATTTCTTCCACCCCCTTACGGGTTAGCCCCAGGGTAGCAGGGGGGAGGTTACGTCCAGGTTACGTGGAAGCTCTTCCCAACGATGGCCCCTGCGTAACCTCGCGTAACCTTGGACTCCCCGCGTAACCTCCCCCTTGGCACCCTGGAAGCATGAGGCACAGGTGGCCTTGGGTTCTCCTCGTGGGATGGCTTCTCCTGGCCCTTCTAAGAGGCCCTGGTCCCGCCCCTTCCCTGGCCTGCTGGAGTCCCGACTGCTTCCCTCCCGGTTCACACCCCGTACTCCCGGCGAAGCCGCTCCACCCGGGCCCGGGCGATGGGGTAGCGGGGATCCTCGGGGGATAGCCCCTCCAGGAGGGCCTCCCAAACCTCCAGGTCCTCCCCCAAGCGCTCTGCGAGGAGGAAGAGGGCCTCCTGGTCCCCCGAGGCCAGCACCGCCCGGCGCAGGGTCTCCTCCAGTTCTAGGCGGAGCGCCTCCACCCCCGGGGCCTGGCTCCAGGGGAGGAGGGGGCCCTGGTAAAGGGCAAGGGCCTGTTCCAGGTCTCTCCCGGAAAGGGCCCTGAGAAAGGCCAAAAGGTCCGAGGGAGGAGGGTCTTCCAGACGGTAGGGGGCGCAGGAGATCCGGAAGCCCTTGGCCCGCAGGCGGTGGAGGAGGGTCTTCAAGGCCCCTAGGTTGGGTTCCCCGTAGAGGGCCTCCGCCAGGGCTTCTCCCGATATGCCCTTCTCGTGGGCAAGGAGGAGGGCCAGCGCCTCCGTGCCCCTAGGCCCTAAGGAGGGTAGGGGACCTCCGTCAAGGAGGCGGAGGGAGGTCTCCTCCCCTCGGCCCAGCAGGAAGGCCCGGGCCTCGGGGCGGAGGGCGGGGGCCAGGCGGGGGGCCAGTGGGGCCTCTACCTCCGCCCCCAGGGCCCTGAGGCGGGCCTCGGCCAGGAGGGCGTAGAGGGCCCCGTCCTCCCGGAGGAGGCCGTGGGCGGAGAGGAGGAGATCCCTGGCCGCCTCCCCCCCTTCCAGGAGCCCCTGGGCCAGGAGGAGGAAGCCCTGGGACCACCCCGCCTGGGGGCCGGCCTGGGCCGCTTCCAGGAGGAGCCGGGCCCTAAGGGGTTCCAGGGCCAAGGCCCCAAGGACCAGGAAGCTCGGGAGGCTGCCCGGGCCCAGGAGGGGAAGGAGGCCCTGGAGGAGGGTCCGGGCCCGCCGGGGCTGGCCCCGGAGGAGGTGGGCCAGGGCCAGGGTGTGCCCGGCCAGGAGGCGCACCCCGGGCAGCTCGTGGAGCAGGAACTCCTCCCCCTCTTCCAGGACCTCGGGGAGGGGAAGGGCGCCGAAGAAGAGCTCCAGGCGGAGGTGGTGGAGCCGGGTCCAGGGGGAAGGGGCCTTGAGGCGGGCCAAGGCGGCATGGGCCAGGGCCTCGGGACGGCCCAGGCGCTCCAGGACCACCGCCAGGGCCAGGTGGAGCCGGGCCTCCGCCTGGGAGTTCCCCCGGAAGCGGTGGAGGGCCTCCTCCAGGGCCACCGCCCCTTCCCTCGGGGGCAGGGCGAGGCCCAGGTGGTAGAGGGTGAGGGGGGTCTGGGCCCTCCGGGCGGCCTCCAGGGCCAGGGCCCGGTACCCTCCCCAGTCCCCCTTGCGGCCCTCCAGGAAGCCCAGGAGGGCCAGGCGCTCCGCCTCGGGGAGGCCTTCTTGGGGGGTTTGGAGGAGGGCCAGGGCCTCCCGGTCCTTTCCCCCCTCCAGGAGGCGGAGGGCGATGGGGAGGCGGGATGGGTCCATAGGACCAGCCTAACGGCCCGCCCCAGGGCCCGCGGGCCATGGGCACCCGTACCCCCTACCTATGCCAGCTCCCTGCACGGCCCCTTGCGCCCCGGAGCTATTCGTCAAAGCCCAGGGCCCGGAGGTAGCGCTTCACCAGGTAGTAGGGCTTGCGGGCCAGGTAGTCCTTGCCCTGCTCCACCCGCAAGACCCAGTGGGGCCGGAGGCCCAGCATCCGGGCGAACCGGGTGGCGGAGACTCCCAGGGTCTCCCGCCTGCGCTTGAGCTCGGCGATGAACTCCTCATCAAAGAGGAGTTCCTCCGTGATCTTGACCTTGCCCTCGAACTTTCCTCCCATGGCGTTCTCCCCCTTCTCCTTGGTCCTGTGACGACTCCTCGGACTGAAGTCCGAGGCTTCTCGGTTCCCAAGATACGGGCTTCGCCCGTGACCACGGGACGGCCCACGCCGTACCCATCCCCGAAGGCCCCGTCCAGGCCCTTGCCAGAACATTCAGCGCGGCGGCCACATCCCGATGCAGGGGAGTCCCACAACCCGGACAGGTAAATTCCCTCACCCAGAGGGGACGCTTTTCCCGGTGGCCGCACACTGGACAGTCCTGGCTTGTATGTTGGGGGTCTACCCCCACGACCCGCCTACCAGCTTCTTCCGCTTTGTAGGCGAGGATTTGGAGAAACTGCGCCCAACCCGCATCCAGAACTCCTTTGGATAGACGGGAGCGGGATAGGGCTTGGATGTTCAGATTCTCGTGAACGATGGTTCCATAGGTATTGACCAGCCTCCTTGCAATTTTATGGTGGAAGTCTTTGCGCTGGTTGGCGATTTTGCGGTGCAGCTTGGCAACCCGCTTTCTGGCCTTCTCGCGACGACGGCTGCCCCGCTTCTTGCGGGCAAGGCTGCGCTGTGCGGCGGCGAGTTTGGCTTGCGCCTTGTGGAGGTACCGGGGGGCCTCGACCATCTCCCCGTCGGAGGTGACGAGGAAGTGGGGGTTGGTGCCCAGGTCTATCCCGATGGCCCGGTTGTTGGAGGGAAGGGGCTTGGGGTCCACCTCGCAGACGAAGACGATGTACCACTCTTCCCCCTCCCTTTTGACCGTGGCGGTCTTCGGTTTCCCCTCCAGAGGACGGTGGAACTTGCACTTGACCGAGCCGATGCCGTACAACAGTACCCGACCCTTTTGAACCTTGACTCCTGTTTTATCCGCTTGGGGGAAGGTGAAGGAGTCGTAGCGCCCCTGCCCCTTGAAGCGGGGATAGCCCGCTTTCCCCTTGGCCTTAAGCCGTCGGAAGAAGCCCTGGAAGGCTTTGTCCACCCGCTCGATGACGTTCTGCAAGACCTGGGAATGAATGCGCTTGTACTCCGGCAGCTCGGCCCGTATCTCGGGCAGATACCTCTTCTGTTCGTAGAAGCCGACAGTCCTCCCGCCCTTCTTGTAGGCATCTCTACGCTCCTGCAAGGCGGCGTTGTACAGGCTGCGGCACAGCGCAAGGGTGCGCTCCAGGTCTTTTTGCTGGGGCCGGGTGGGGTAGAGTCGGTACTTGAACGCCTTATGCATCGTCTACCTGATGCTTGCGCTGCTCCTGGATGTAGCGCTCGATCACCTGGCGCGGTCGTGTAAGGATTTATGTGTAAGGGTCCGTGTTTAATAGGGGGGCACACCTTAGCACGAGGAGGTGCCCCGTGGACCAGGATACCTTGCGGATCTTGCTGAGGGAAGCGGTGCGGGAGACAGTAGCCGAGGTTCTGCAGACGGTTCTGGAGCTGGACCGGACGGCCTTCTTGCAGGTGCACGGAGGCCGCAGGAACGGCTACTACCCCCGCAAGCTGGAGACCACCTTCGGCCAGGTGGACCTGAAGGTCCCTAGGGATCGGGAATCTCGGTATTACCCGGCTTTCCTTAAGCCCTACGTCCGCCGCCTGGTGGACGTGGGGGAAGTGGCGGTAGCCCTTTACGCCGCCGGGGTCAGTCAGCGCAAGGCGGCCGAGATACTGAGCCTGCTCTTAGGCCACCGCTACTCCCACGAGACCCTGAGCGCCCTGACGGACGAGGTCCTGGAGGCGGCAGGAGCCTTCCGCACCCGGCCTTTGCCCGAGGAGATGGCCTTCGTCTACCTGGACGGGCTTTCCCTAAAGGTCTTCAGGGAAGGAGAAGGGATCGTACGGGAAAGCGTGTATGTGGCCCTGGGCATCGCCCCTAATGGGGAGAGGCGGGTCCTGGGGTTTTGGCTGTTGCCCACGGAGAGCGCCCTGGGATGGGAGGGGGTCCTGGGGGAGCTTTGGCAGCGGGGCCTGCGGCGGGTATTGCTCTTCATCACCGACGGGCTGCCCGGGCTTCCTGAAGCGATCCGCAGGGTCTACCCTCAGGCGGAATGGCAGCGGTGCGTGGTGCACGGGGTGCGGTGGAGCCTGTCCCAGGTGCGGGCGCGGGACCGGGGCCTGCTGGCGGAGGACCTGAGGCGGGTGTACGGGGCGGAGAGCCGGGAAGAAGCTCTTGGGGCCTTGGAGGAGGTGAAGGCCGCCTGGGGTTCGCGGTACCCGGGGGTGGTGGGGCTTTGGGTACAGGATTCGGGGGCCTTCCTGCGGTTCTACGGGTACCCCAAGGTGCTTTGGCCGTACCTGCGGAGCACCAACCTGATGGAGCGGTTTATCCGGGAAGTGCGGCGGGGGACGAAGGTGCGGGACCACAAGTTTCCTAAGGAAGAGGCGGTGTACAAGCTTCTTTACCTGGAGTCGGAGAGGCAGGAAGGGAGGTGGGCAGAGAGGAGGAACTGGCTAAGATCCTGGAAGCCGCCCGGCAACACCGCCTCTTCCCCCTCTTCTACCTCGCCGCCGCCTTCGGCCTCCGAAGAGGCGAGGTCCTCGGCCTCACCTGGCCCGACATAGACCTGGAAAAGGGCGAGCTCCACATACGCCGCGCCCTCGTCAAAGACCTCGCGTCTAACAAGCCCATCCTGACGGGTACCAAAACCCCCACCTCCAACCGCACCATCCCCCTCACCGAAGAAGCCATCGCCATCCTGGAAGAACACCGCCAGCGCCTCATAGACGACGGCCTCTACCAACCCAACGGCCTCGTCTTCCCTTCCCTCTCCGGTACCCCCATCCGCCCGGAAAACCTCAAACGGGCCTGGAAATCCATCCTCAACAAGGCCGGGGTGAAGTACGCCCGCCTCCACGACCTCCGGGGGACCTTCCTCACCCGGGTCATCCGCCAAACCGGGAACCCCAAACTCGCCGCCGCCCTAGCAGGCCACAAAACCCTCTCCACCACCCTCAAGCACTACACCCACATCTCCCAAGAAGAACTCAAATCCACCCTCCGCTCCCTTCAGGTCTTGCCAAAGGATAAGGACCCCGAAGACAATTGA

Protein sequences of DBSCAN-SWA_1

>NC_017278|1694078:1759605|1695528_1695969_+|WP_014516095.1|DBSCAN-SWA
MKRLLLLLTLLLGVASAQSAIQMRFGYGETLGLTFGAGVENRLRQNLVGRLSAEIAPAAPGVALEGALLFKPDLGQYEPSLSGLLPYFGGGVGAVVGPRPTAGVSFTLGLEGLLDPYTGLLAESTYVYGFADFPKVWRFTLGVNFR
>NC_017278|1694078:1759605|1726772_1727612_+|WP_081477230.1|DBSCAN-SWA
MCQENRTPRLSIPSWAATAGWLLLCLAFAPHALGQEMRVETVSYKNGDLELRAFLYRPPGPGPYPAIVYNHGSEKNLAYIDRLAVPFVRQGYVFFAPNRRGHGRSPGTYILDVLGTLRGAEWSQALVRLHEEQLSDQLAGVAYLKNLPFVDSGRIGVYGWSFGGIQTLLAAERSESGYKAAVSCAGAAQTWPASPDLRARLSEAAQKAAVPLFLLQAQNDHSLAAIEGLSEVLRRSGKPHQSRVYPAFGTTPQQGHEFCIQGSEIWGPEVFAFFAQHLR
>NC_017278|1694078:1759605|1697056_1697464_+|WP_041434017.1|DBSCAN-SWA
MKRGPLLLTFAWMVALVATLGSLYYSEVRLFLPCELCWYQRIFMYPQAILLGLALWRQDLSVWPYALALSLIGGGISTLHLLEQKFPELFTLACKPPVPCSVEYMPQFPIPLQALIAFVLIAVSMALLAKEARGR
>NC_017278|1694078:1759605|1751824_1753021_-|WP_003043751.1|DBSCAN-SWA
MAKDLTPPSGTFSFFLLAFLLTLTGQGLVVAGLWRFLEAGASGLQTSVLTLVQALASILTPFLLQSWLETRPQMVLRLLAFGLGVAALLALGSPGLSTFLLLYAALLALFLFLTAALAIYGVLLGSALPRLFPKEALSQANARWEMANTLGLVLAPLIGGFAVDRLGPYALPLFALPLGVALVLLLGLKAPPPLGPSEGRRKAFGGVPLGVLLPVALPALLPALALTGGGVLTALLFHDLKRPEGLGIAWAGFSLGGFLVAQALTRVSLPPVLGLLGGLGLLGLGNLGNGLLPYPHLLLGSLVSGAGVSVARIAFRTFLQRLAPPETLVGLFAYVNVLTQTARVLGSPLGGGLGDLLGPRGAFVAFGSVFLLASLLFPPLLRLSQRVLSPRGDAEGRG
>NC_017278|1694078:1759605|1697765_1698479_-|WP_014516099.1|DBSCAN-SWA
MWPPYHQPRPLVFFYKKPSPLFDRLVAEVTTAKLPLFPYPVETENPWAALPCLWPLGFAGAVLAEALPPPEGVRLEAEAQAAGLMDLAVPGAKGLWGQYTEGVALERFLGQHFPGAKALWLGPLRPALAPFLRPLAQVAVAASTFAEGDSFLARLPERARGPVVARAEEVQALALRADLLLYAGGRLSLEHLQPFHVLVALVPPDRGVWERVQAVYAPEDLLGVRVRVILEGLGYPV
>NC_017278|1694078:1759605|1711833_1713396_+|WP_014516114.1|DBSCAN-SWA
MKGVEITKDHPLLQEVLTEEALGFVVALQREFNPVRKALLERRQALWERYRAGEKPDFLPETAFVRGGSWQVAEAPKDLNDRRVEITGPVDRKMIVNALNSGAKVFMADFEDALSPTWDNVIQGQKNLMDAVRRQIDFVSPEGKAYRLKEEVATLVVRPRGWHLVEKHVRVDGEPISASLFDFGLYFFHNAHELVRRGSGPYFYLPKMESHLEARLWNQVFNFAQDYVGLPRGTIRATVLIETILAAFEMEEILYELKEHAAGLNAGRWDYIFSCIKKFATTAPIFPDRAQVTMTVPFMKAYTELLVKSCHIHGAHAIGGMAAFIPSRKDPEVNERAFQQVRADKEREAGQGFDGTWVAHPDLVPVAMEVFDRHLGDRPHQKHVKREEVQVTAQDLLDFHVPGGKVTEAGLRNNISVALQYLNQWLLGNGAAAIFNLMEDAATAEISRAQLWQWVHRGATLEDGRTVTPELYQKVKEEELEKLGGREVGRYKEAEEILDRLVLSETFVEFLTLVAYEYID
>NC_017278|1694078:1759605|1704284_1704719_+|WP_014516104.1|DBSCAN-SWA
MSATGLEVFDTTLHKTHAWLKAIMEALGLEDRHRAYMALRAVLHALRDRLPVEEVAQLGAELPMLVRGLYYEGWDPTGKPLKERHKEEFLAHVARELRTPSGPALDPEAAARAVFQVLAQKVSEGEIRDVQNLLPKELRELWPR
>NC_017278|1694078:1759605|1701528_1702482_+|WP_014516102.1|DBSCAN-SWA
MRELLPGLYLLPVPIPYPLKTVNLYLLKGEGEVALVDTALGTKTARGTLELYLAELGLCFQDVRTVLLTHHHPDHYGLAGFLEGLGAKVYLHEEELGRGHRFWQEPEAFEGASWQLFLEHGTPEEALGGIRETMAKTRERVHPPKNPVPLREGEVLEVAGKRLRVVWTPGHADGHVAFWLEEEGVLLAGDALLERVSPNVGLWAYTRENPLRDFLASLERLAGLPAQVAYAGHFGPIPQVGKRAQELALHHQERLEALLRHLEGPETAWELSLKLFPQELDAAGRRFAFAETLAHLEYLRHEGQVGREGPPYRYFRA
>NC_017278|1694078:1759605|1723359_1723539_+|WP_041433848.1|DBSCAN-SWA
MTPKLRRSFLVRVYTAPGPDGVPRCSYRVHDLKTGREVEFATWEELQAYLQRRWPGRLR
>NC_017278|1694078:1759605|1705656_1706472_-|WP_014516106.1|DBSCAN-SWA
MAHEHEHEFILEIPEFEHLAYEVEGGIALVTLKRPEALNALSQDLLQELAEVTEVIHQDPEARVVIFTGEGKAFAAGADLKEIAALKDPFMAREYALLGQQVFAEIAALPVPTIAAIHGYALGGGLELALACDLRVASKEAKLGLPEVGLGLIPGFGGTQRLPRLIGRGRALDLIFTGRHVPAEEALALGLVNQVGEDALEEAKKLAQKILKNAPIALALAKESVVRGEGLDLAEALEIEADLFGYASATEDMKEGVRAFLEKRPPNFKGE
>NC_017278|1694078:1759605|1735240_1736863_-|WP_041433850.1|DBSCAN-SWA
MGAERWIAKVVEALGRSPRTPEEALATLGVLLRANPTEKEEFLRDAHAAWVGGGWAIRGDNSPEARVVLMALEEATRRLARQRNWQGKQERQEVRLSLAPEVAERVVVVSTSPKGVKEGVFRVGGTGLSQKALWAAAYRVAKGEKVYLVGSLASKARKMVLARVAKILTKEAQKNTVKLPWGQARLLPGDRWEDLEAPEPRIAVAIRELRRWYEEEKREEEEEEREGWAHQTRVDPWVVKALISSVDPDAEEVDLAYFRDLQGDALSILDEWILEVDVYNPSELYWALGVSKGSRFKREGGWWGVVATVLRFSKPFTFAEVKEVWQEKRKGWGWEFKVIRLLQPIVAWEVALMGFKDPEYAYSWGLTEGVKIAKRLKAGKLNPLVFLVPEIRKRLAELRAQEVGVFKLSHREAKAIRRYFGLLKEKTPEEAAKEAGLPKELREALEAAGHLSTDLMREVGVEPAEEMDYDALLLRAKVKSVLEEVKLLFGDTGVAFVEALMEGASVEGVVSRVMCKSLCTGGIPLLKHLLQHLLHLREPL
>NC_017278|1694078:1759605|1753013_1754489_-|WP_014632236.1|DBSCAN-SWA
MHERGLQLPKVVGQQHDFLMVAIDTGNFILAYEEDLEEGLGSEYERLWVEDVPLVLASDASVVLRRERFGGILYGFKRGIFLNQEAFDLVRSFVVATRPSLALKQVLKEGGLSEITKGFVEAAGHLILYLIAEGYLRPSQEGLESKALFLDDQHFSDDRYYRPLSMEIELTNRCYRRCAYCAYESGPEPKIPLREELTFDEWGYILDSIRKEGVFYLEFTGGDPLSRPDGLEIIRLADELGFSVQVNTDLSVLRDSDLDKIASTKNLNFVGTTLDGSSPDSHDLLRGKGGFKTTLRQISLIAKAGIPLAVFTVVHKKNYTEIRKIGEIATQNNAMYGIAPMYPAGRGASLNHLVLSQEEWDFAVGEYMDMVRLGAIKPHQRLWYKLSRELRSENPARDQIWLTSRGNRALRVDPRGNVYVSAKLREWRPRYSFFGNLLTSTLADIWENSPLLQELRKIPVQPNFFDAVDIRTIPNYTSEIPLADGSASQHG
>NC_017278|1694078:1759605|1709286_1710600_-|WP_014516111.1|DBSCAN-SWA
MSALEPLLEFLSIPSVSTDPRHQKDVRRAALWLKERLEVLGFRSELHETPLHPILYAERLLDPEAPTVLVYGHYDVQPPDPLELWESPPFSPTVREGRVYARGASDDKGQLWAHVAALEGLEARVNLKFLVEGEEEIGSPHLLPFVRAHREKLRADVVLVSDGAMFAPHTPTLTYGLRGLCYLEVRLQGARRDLHSGAFGGVAPNPIQALGWILARLKDGTTGRVLIPGFYDRVRPVSEEEKRLWPPLDEEALKGELGVEVLPGEEGYSPLERLWARPTLDPNGIFGGYQGEGSKTVIPAEAGLKLSMRLVPDQDPEEVADLAEAYLKALCPPGYRMEVRRLHGGKPVLTDPQSPPMRLMARALEEVWGRPPVYAREGGTIPVVAELQEALGAPVVLLGLGLNDDNLHAPNEKFDLVNLEKGILAIRRFHGLLAESG
>NC_017278|1694078:1759605|1727762_1730456_+|WP_014516126.1|DBSCAN-SWA
MRHRILWSIGVVLVLLGGCGNRTEAPETNPQVFVGEVSGTDALIALVVGEKGVLAYVCQGANSWDNTTYGGYTGWFHGLARGKQLDPMTSASGHVLSGQIADQTARGTLTLANGYILNWTAEKVRSGTGAGLYSLEENGMLTGLIVTNAGKMAGASRLNTGDASSLSAPVQVVTAPSSTNTSPTVSVTFPNLGTRDLNLTPVDLLRHMVVPDSPTIIVLLHGATARTPLDNPRVDGVPGTRKHARHFWTYPFVAALLGADPSKNAPLVTLEGTDITGSAFLNVGLTLPGQGTDQVPASDQCTLGDMATAERYTRGQTTPPKLTVLLGHRDAKDSLVEQAMYAVDQIYACVTLFEQTFRRKPKLLFVAQSWGGLITRFILSNPTRASLQAITSPTSLRFPTDNARYDTGDLSTRVKMDYLRNLTYYAVTMATPHQGVRIIDRAREVVQVVGMLRGTLAAADREQENLLNAWRNAVSLLLNLPPADALRAEPVVAALAWFEQFAESTFAINRVWAESHTGLWVALNTGPLHPSRAIRTNQSPIVGAKNQLIPIYAFGARNPGSTVADTLNLGQIPGDFQALGSLQKGATKQSWVIQAIGGDFVYRFLDLSTGPRTPFAGFANQLDRTERVDAIALLRTALDSVAPQLNLFFRAQFGSDSASLLRFMLEQLRVPSTSLVPIFLNQGFTVDLGGSVQLPVPRLSCQGRNITLDYGPLVIALVSHYGSLQQAASALASLSFPALLSALNSLGGDFSGLATNLSTWMTQTLNTLQNLPVACVNPANWTLSWPLTSVPAPRAVPTGVPVSDRVIDNDGLAEFDSAMGFRLGTSINEFFDHTRTDFVVDNKPLPGSWYRRYRSDLEQLNHDTMREEAGRFVWTDILSRNPGPLPSEQGDLSVYPQ
>NC_017278|1694078:1759605|1718360_1719482_+|WP_041434020.1|DBSCAN-SWA
MASLYVHVPFCPTLCPYCDFHVVRRAPGWVEAYLKRLAEEAQALFAQHPGPLRTLYLGGGTPSYLRERELLALFQALPWSLAPGAEVTLEANPGTLNRKRLALLRALGVNRLSLGVQSFQDPVLRFLGRAHGRKGALRAVEEALAAGFRVSLDLILGLPMQDVERDLEEAAALGVGHVSAYTLQVEKGTPFALLGLGEDPERAAWAMERAAEVLGQAGLERYEVSNFARPGEEAAHNLVYWRNGFWLALGPRATGQYPDGAPGVYALRRTHPPLPRWLQGEAPEEEAISPLGHAKESLMLGLRLREGVDLEEVARRSGLPLPSLLQEAVSQLVQEGFLEAAGPRIRPTPKAFPLLHRVVLRLWEALDPLEAPG
>NC_017278|1694078:1759605|1708558_1709290_+|WP_014516110.1|DBSCAN-SWA
MRLKVDVLPTEELVYPDVVLVVDVIRATTTAACLLEAGAEALYLVAGLEAARAFKDEDVVLAGEVGGLRPPGFDLGNSPREALEAPVGGKVVVMSTTNGTKAAHAAARTAKHVLLASLYNAHAAARLARELATEEVAILCAGKEGRVGLDDLYTAGVLAEYLGLLGEVEPEDGARIALAVKRAYQDPLEALSLSAAALALKGVGLEGDVPFCAQVARSAAVPLLTGRVGEALIFKRALPGQGI
>NC_017278|1694078:1759605|1754754_1756239_-|WP_014516140.1|DBSCAN-SWA
MDPSRLPIALRLLEGGKDREALALLQTPQEGLPEAERLALLGFLEGRKGDWGGYRALALEAARRAQTPLTLYHLGLALPPREGAVALEEALHRFRGNSQAEARLHLALAVVLERLGRPEALAHAALARLKAPSPWTRLHHLRLELFFGALPLPEVLEEGEEFLLHELPGVRLLAGHTLALAHLLRGQPRRARTLLQGLLPLLGPGSLPSFLVLGALALEPLRARLLLEAAQAGPQAGWSQGFLLLAQGLLEGGEAARDLLLSAHGLLREDGALYALLAEARLRALGAEVEAPLAPRLAPALRPEARAFLLGRGEETSLRLLDGGPLPSLGPRGTEALALLLAHEKGISGEALAEALYGEPNLGALKTLLHRLRAKGFRISCAPYRLEDPPPSDLLAFLRALSGRDLEQALALYQGPLLPWSQAPGVEALRLELEETLRRAVLASGDQEALFLLAERLGEDLEVWEALLEGLSPEDPRYPIARARVERLRREYGV
>NC_017278|1694078:1759605|1730633_1731854_-|WP_014514494.1|transposase|DBSCAN-SWA
MFNRGAHLSTRRCPVDQDTLRILLREAVRETVAEVLQTVLELDRTAFLQVHGGRRNGYYPRKLETTFGQVDLKVPRDRESRYYPAFLKPYVRRLVDVGEVAVALYAAGVSQRKAAEILSLLLGHRYSHETLSALTDEVLEAAGAFRTRPLPEEMAFVYLDGLSLKVFREGEGIVRESVYVALGIAPNGERRVLGFWLLPTESALGWEGVLGELWQRGLRRVLLFITDGLPGLPEAIRRVYPQAEWQRCVVHGVRWSLSQVRARDRGLLAEDLRRVYGAESREEALGALEEVKAAWGSRYPGVVGLWVQDSGAFLRFYGYPKVLWPYLRSTNLMERFIREVRRGTKVRDHKFPKEEAVYKLLYLESERQEGRWAERKLKGFSEVKEVLEKMLQERYAPRTQTLTHNS
>NC_017278|1694078:1759605|1706475_1707183_-|WP_014516107.1|DBSCAN-SWA
MSPIHVRGQPGEVAERVLLPGDPGRAEWIAKTFLEDPVQYTSYRGLLGYTGRYRGVRVSVQTTGMGAPSASIVAEELVSLGARVLLRVGTCGAVDGALAPGDLVVAQGAVPLDGATRQYLEGRPYAPLPDPELFRALWDQARKKGYPHHVGLVATEDAFYATTPEGAKAWARYGVLAFEMEASALFLIGKLRGVKAGALLTVSNRIGDPELAPPEVLAEGVRRMVEVALEALLEV
>NC_017278|1694078:1759605|1733605_1733917_-|WP_014516129.1|DBSCAN-SWA
MMTLDALTDQMLAELRMETGARGPGLVLWGETPEELELALYNMLPNLEEPIRGWVRKVLPDLVETSAREGYTVLVLVPTEEGVYAKGASVQLEYLPLEGHLEG
>NC_017278|1694078:1759605|1695968_1696883_+|WP_014516096.1|DBSCAN-SWA
MGFLDRLKAGLAKTREKLLGAIPWGANPEEVLEELEMALLAADVGLAATEELLAQVRASGRKDLKEAVKEKLVAMLEPDPRRATLRKLGFRPQNPKPVEPQGHVVMVVGVNGVGKTTTIAKLGRHYQELGKKVMFCAGDTFRAAGGMQLAEWGKRLGIPVLQGAEGADPAGLAFDAAQARKARGYDLLFVDTAGRLHTKHNLMEELKKVKRAIGKADPGEPGEVWLVLDAVTGQNGLEQAKRFHEAVGLTGVIVTKLDGTAKGGVLVPIVRTLGVPIRFIGVGEGPEDLQPFDAEAFVEALLEA
>NC_017278|1694078:1759605|1720370_1723322_+|WP_014516123.1|DBSCAN-SWA
MATSARLYLLDEPHALWEGCPYPLPPSRPGQLLLFLAYRGEWVARETLAGLLWPEIPEEEARHNLRVALHRARSLPWAQAVEVNREQVRFVLVTDVAEFRAALGRGDWEEAVRIHRRPFLMDFPLREAPALEDWASLERQSLLEAWQYAAKRRAQELEEAGEAEEASRLLLEVLRHDLLAEDVLQAYLRAAQMAGQREAALKVYDRFRRELGEGLGLEPARVTQELAQALRQTQPLAAPASPRLTFPLGLLHPPRMVGREEELTALRRARFALVSGEAGVGKTRLLLESFPEAPRLRCLEGLENLPWHPILVHLRRHLDKLPDLGPYREDLARLLPEAFPGLTPPPPEPGSSKPRLLEALARSLASAERLLFDDLQWADENTLELLLYLLERGQPWIGTYRPQEVGPALKRTLEALHAHGVETVVLKPLEADAVHALLADLTGAEEGPPLFSRWLRGKTGGNPFFALEVLKTLFEGGVLREEGGRWRTPLDEVTRDYTELQVPPKVAGVVARRLGRLSPEALRTLQAASTLGEGFSPQVLAPMAGLSEWAVMEGLEEAEQAGIVAGNGFVHDLFRQSIYQGLSQARRQFLHAQAAQSLQGQAPPQVVAEHWFQAGAHGEAAHNWLVAARAYLKSSLPEEAARVLERAYPHAQGLEGPEMAAHLARSYRELGQYAQAQRWIQEALRHPSPRWQADALVEQTWVLLGEGRLEEAAKVLQEAQEIQARLEPEPLEEGSLELALAKLRSNLAFRQGQFTASCQTLEPLAARLRTQGPSLALAGILVSLGSSYDHLGQETQAIATLEEALQVAQKVGARYYLVDGANNLLGCLIRQGRCEEGLAQAKAALALGEYEGTAFLRNNLAVAYLSLEQEKEALALFEANAHGAPDAMLRVLAWARLAELYPRHGLAGAVEHALDQALETALGMDLQAVPVRFLLALLRWGTEAQLRRAVPLLQEGVAETLPPPWREAYLEALAQRGLPPSSP
>NC_017278|1694078:1759605|1707208_1707838_-|WP_014516108.1|DBSCAN-SWA
MRPVLQVEDLGFAYGNGFLFRHLSFRLAPGEALAVLGPSGSGKTTLLHLLAGLLPLQEGEVYWEGEPLRGLSQGALARRRLSFLGLVFQHHFLFPELTALENVLAPGYLAGRVDRGWALALLGRLGLGGRAHFLPQRLSGGERQRVAVARALYLRPRLLLADEPTASLDRRQAREVLRLLQELAQEVGAALVLATHDEALVEGFPALKL
>NC_017278|1694078:1759605|1717123_1718347_+|WP_014516118.1|DBSCAN-SWA
MRAAFLKEAFLQALKATHPGALTAKALPPRKPDLILAVGKAGAAMLRAALDRYGEVPYHLTLPKGQEALGLKAVQAGHPLPDGESQRAAEEVLDLLKGLSPKGRVLALLSGGGSALWCAPLGINLEEMRKLTQALLQSGASIAEINAVRKHLSRLKGGRALLATRARVQALLLSDVPGDDPSVIASGPFHPDPSTYREALAVLDRYGLDFPGARRVLEAGARGEIPETLKPGDPATRRLRWRLAGANLDLLKAARDFLRGEGYREVILSDRFGGEARGLARFHAELVATIRAHGLPFRKPLFLLSGGEAQVRVRGGGLGGRNLEFLLALYAYLQEPLYALAADSDGLDGPSGVAGALLTPEVWGLGLDPQPFLAENDSLGFFARAGTLLTLGPTGTNLNDFRLLFVN
>NC_017278|1694078:1759605|1748421_1749642_-|WP_014514494.1|transposase|DBSCAN-SWA
MFNRGAHLSTRRCPVDQDTLRILLREAVRETVAEVLQTVLELDRTAFLQVHGGRRNGYYPRKLETTFGQVDLKVPRDRESRYYPAFLKPYVRRLVDVGEVAVALYAAGVSQRKAAEILSLLLGHRYSHETLSALTDEVLEAAGAFRTRPLPEEMAFVYLDGLSLKVFREGEGIVRESVYVALGIAPNGERRVLGFWLLPTESALGWEGVLGELWQRGLRRVLLFITDGLPGLPEAIRRVYPQAEWQRCVVHGVRWSLSQVRARDRGLLAEDLRRVYGAESREEALGALEEVKAAWGSRYPGVVGLWVQDSGAFLRFYGYPKVLWPYLRSTNLMERFIREVRRGTKVRDHKFPKEEAVYKLLYLESERQEGRWAERKLKGFSEVKEVLEKMLQERYAPRTQTLTHNS
>NC_017278|1694078:1759605|1751090_1751624_-|WP_014516139.1|DBSCAN-SWA
MNPVWKLAFLSEALGDLGAALGFSALSLEVARTGEAFWVGLFAALGYFTLGPLLLLSPRLDRGDPVRALLLLALPFPPFLAGGLLYGFAVGVTGVHLRAVRGWLLPEEALAGSLAALRALIYGAGALGGTLSGVLGGIGVTLPLRVALASFLAFYLFALGPLHPRRLEEVEAMGRAS
>NC_017278|1694078:1759605|1713435_1714821_+|WP_014516115.1|DBSCAN-SWA
MGFLEELRALFPPGRVLTQGAALAPYESDALTAYRQRPLAVVLPERKEEVVQTVRLCHRYGVPFVARGSGTSLSGGSLPVEGGIVLALNRMNRILRLDPQAMVAVVEPGVVNLEVSRQAAPFGLYYAPDPSSQPVSTLGGNVAFNSGGAHCLKYGMTANHVLGLEVVTPEGEVVRLGGEGLEGVGPDLHGFFVGTEGLLGVAVEITLRLLPKPEAYHTLLAAYGSLEGAGEAVSLVIRRGLLPGAMEIMDRLAIEAAEAAVQAGYPKAEALLIVELEGPKEEVAEEALVLEEVIRESGALEVRVAGSEAERQAIWKGRKAAFSAVGRLSPDYLVQDGVVPRSRLAEALREIGRLSQAYGLRVANVFHAGDGNLHPLVLYDGKKPGELERAEALAGEILRLCVRLGGSLTGEHGIGVEKKGYMPEMFAPEDLLAMEGVKKALDPKGLANRGKVLPEVARAGG
>NC_017278|1694078:1759605|1719901_1720291_-|WP_014516122.1|DBSCAN-SWA
MSASHDRELYEAWVELLSWMREYAREKGVRFEKEADFPDFIYRMERPYDLPTTIMTASLSDALGEPFLLADVSPRHAQLKRIGLRLPRAHIHLHAHYEPGKGLVTGKIPLTKERFFALADRARAALALA
>NC_017278|1694078:1759605|1745954_1746341_+|WP_014516135.1|DBSCAN-SWA
MPEEKLLDASALLAYLQRESGFEVVRQALREGAAISAVNLAEVVGKLKGRGKDADRIVARLLAMGLEVVPFTLEEALEAGALDPLTRPLGFSLGDRACLATGKVRGLEILTTDRAWSQIPGVRIRVVR
>NC_017278|1694078:1759605|1723626_1726746_+|WP_081477229.1|DBSCAN-SWA
MKPRTQAPMVRFRQYWLALALLGLLLSCAQPSPPPPQVVRVEVAPGGLLLTRPGESQPLSARAYDAQGKEVKANFTYSSSNPAVASVTPEGRVTAQADLGSARVVVQAGQARAEVGVMVAQPVAGATLVSDSQVVRIEGTDPNAPFKVGYRYVVTLEGVDPPAVGSVLMSQGSLPVAGRVVEARQSGSQTLVTLELVPLGELLTRYRLEETFNLAHLPAVVPDSVGSNFDVTPKGNGQYTLRLKPGRVIRTTARPAGSVRPMREFEVGPLECETELSLVDLSVDEVEVEVDLSSIGFELLWTEANKKLLMVGSPKAKLAFNPSLAAALEGSLECKLEFFQIPLPVPSVLSAIARLYIPVGAGFEISGKVPVAGVGFESSTEYLLELRAGVECTPTCSFARRFERRETQAEFKWVLPREIPRGLKVEAEASGFLFATINTGLQAHITNTGKIFGVRISDFEFFVAKAALKLDGKLASEETQVRDPEFAAKYGLSLELSLKTGKDLQEALEALEILVTAINLKFPFELGSSPTATTLTADRNSFRFGDEVRFRVKLDNTEFPVLGYQVEAVRVYRNTGTPENPVLVLANQATASPGQTEFEIPWVATEDGQVVEGSGERTRHHFVAFVKTKPLDTRLELGGIKSFTGARGELDPTFGSGGKVTTDLGSSFDGAHALVLQPDGKLVAAGYSSNALGLADFALVRYNPDGSLDTSFGSGGKVTTEVVQGDDKAYALVLQPDGKLVAAGYSSEGLGDFALVRYNPDGSLDPSFGTGGKVTTNFHFDVAHALVLQPDGKLVAAGWSQIGSNSYFALVRYNPDGTLDTSFGNGGKVTTEVGSSSDGANALVLQPDGKLVAAGYSRNAAGDYDVAMVRYNPDGSLDTSFGSRGKVITPVFSTFGSALVLQPDGKLVAAGFSTNSAGNDDFALVRYNPDGSLDRSFGTGGKVTTDLGLPRDIVHSLVLQPDGRLVAAGSSNNDFALVRYNPDGSLDPSFGIGGKVTTAVGSSYDIAHALVLQPDGRLVAAGRSRNASGNSDFALVRYR
>NC_017278|1694078:1759605|1694078_1695494_+|WP_014516094.1|tRNA|DBSCAN-SWA
MVVTRIAPSPTGDPHVGTAYIALFNYVWARKNGGRFLVRIEDTDRARYVPGAEERILAALRWLGIPYDEGPDIGGPHGPYRQSERLPLYRQYAEELLRRGWAYRAFETPEELERIRQEKGGYDGRARHIPPEEAEARARRGEPHVIRLKVPRPGTTEVRDELRGVVVYDNGEIPDVVLLKSDGYPTYHLANVVDDHLMGVTDVIRAEEWLVSTPIHVLLYRAFGWETPKFYHMPLLRNPDKTKISKRKSHTSLEWYKAEGFLPEALRNYLALMGFSMPDGREIFSLEELIAAFTWERVSLGGPVFDLDKLRWLNGKYIREVLSLEEVAERVKPFLEERGLSWPDEAYLRRAVELMRPRFDTLKELPEKAPYLFQEDYPVTEKAREKLREGLDLLKEVQPLLEAQEAWSEAALDTLLRGFAQAKGLKLGQVAQPLRAALTGTLETPGLFEIMTLLGKARTLARLERALGKGA
>NC_017278|1694078:1759605|1698489_1700577_-|WP_041434018.1|DBSCAN-SWA
MDEAWLSSLNEAQRQAVLHFEGPALVVAGAGSGKTRTVVHRVAYLMARRGVYPSEILAVTFTNKAAEEMRERLKAMVKGAGELWVSTFHAAALRILRFYGERVGLKPGFVVYDEDDQTALLKEVLKELGVSAKPGPIKALLDRAKNRGEPPERLLADLPEYYAGLSRGRLLDVLHRYQQALWAQGALDFGDILLLALKLLEEDPEVRKRVRKRARFIHVDEYQDTSPVQYRLTKLLAGEEANLMAVGDPDQGIYSFRAADIKNILQFTEDFPGAKVYRLEENYRSTERILRFANAVIVKNALRLEKTLRPVKSGGEPVRLFRARDAREEARFVAEEVLRLGPPYDRVAVLYRTNAQSRLLEQALASRGIGARVVGGVGFFERAEVKDLLAYARLALNPLDAVSLKRVLNTPPRGIGPATVEKVQAIAQEKGLPLYEALKVAAQVLPRPEPLRHFLALMEELMDLAFGPAEAFFRHLLEATDYPAYLKEAYPEDLEDRLENVEELLRAAREAEGLMDFLDKVALTARAEEPGEAGGKVALMTLHNAKGLEFPVVFLVGVEEGLLPHRSSVSTLEGLEEERRLFYVGVTRAQERLYLSYAEEREVYGRPEASRPSRFLEEVEEGLYEEYDPYRLPPPKPVPPPHRAKPGAFRGGEKVVHPRFGLGTVVAASGDEVTVHFDGVGLKRLSLKYADLRPA
>NC_017278|1694078:1759605|1710596_1710935_-|WP_014516112.1|DBSCAN-SWA
MDKDRPVYVISVAAELVEMHPQTLRLYERKGLIKPKRSGGKTRLYSERDIERLREIRRLTQELGVNLAGVEEIMRLRSELEALQARFEREVARLRLLLLEGGTLAEEGSMGA
>NC_017278|1694078:1759605|1746371_1747127_+|WP_014516136.1|DBSCAN-SWA
MTQLEAATGSLFPKAPQWGNYLDIWRVLPFFHYLKNSFLVCSLTTAFALAVATFAGYALARFRFPGAELFGGSVLVTQVIPGILFLIPIYIMYIYVQNWVRSALGLEVRLVGSYGGLVFTYTAFFVPLSIWILRGFFASIPKELEEAAMVDGATPFQAFHRVILPLALPGLAATAVYIFLTAWDELLFAQVLTTEATATIPVGIRNFVGNYQNRYDLVMAAATVATLPVLVLFFFAQRQLIQGLTAGSVKG
>NC_017278|1694078:1759605|1737098_1738319_-|WP_014514494.1|transposase|DBSCAN-SWA
MFNRGAHLSTRRCPVDQDTLRILLREAVRETVAEVLQTVLELDRTAFLQVHGGRRNGYYPRKLETTFGQVDLKVPRDRESRYYPAFLKPYVRRLVDVGEVAVALYAAGVSQRKAAEILSLLLGHRYSHETLSALTDEVLEAAGAFRTRPLPEEMAFVYLDGLSLKVFREGEGIVRESVYVALGIAPNGERRVLGFWLLPTESALGWEGVLGELWQRGLRRVLLFITDGLPGLPEAIRRVYPQAEWQRCVVHGVRWSLSQVRARDRGLLAEDLRRVYGAESREEALGALEEVKAAWGSRYPGVVGLWVQDSGAFLRFYGYPKVLWPYLRSTNLMERFIREVRRGTKVRDHKFPKEEAVYKLLYLESERQEGRWAERKLKGFSEVKEVLEKMLQERYAPRTQTLTHNS
>NC_017278|1694078:1759605|1743436_1745554_-|WP_014516133.1|DBSCAN-SWA
MRRILALVAVLGWALGVPVTFRYTPPPGLEVRTVSLRGSFNGWGETPMKKEDGSWTITLDLEPGEYQYKFFINGQWPKDMCHDPTFGTPMVDPTAAGCVDDGFGGQNAVIVVQAPVAPGGPVALEFAHDPKEARYLSLADGKLSLRFSAAEGAVAKAWLEAGGERFPMHRQLFFPGTEVWRVAVAPGIGAYRIRVQTQDGREEVFGPFTPPAHPFAEVPWVGEGVGYQIFPERFFNGDPSNDAKALETDEYRFNLVWQRSGEMGPHLSGWTDPPSVHHCCHQYFGGVLAKLPHLEALGVRLIYFNPLFDSGSAHGYDTHDHLEVSPKFGDKTLLKKLLEEAYRRGMRVIFDFVPNHTGLGFWAFQDVVRRGPASPYWNWYFIKRWPFTPGDGQAYEGWWGLGNLPKLNTANPGVRRYLLEVAKYWLRFGFDGVRVDVPGDLLDAHGFFKALRTELKGLKPEAYLVGEIWQRDTSWLQGDEFDSLMNYAIGRDILLRFAKGGSLALYNGRRALADLSRTYALYPEAVAGMGFNLISSHDTARLLTEVGGGGLGDVPSSEARARQRLAAALLYALPGVPVTFQGDECGFTGEKPDKPPYDLQRYPFQWDRCRGETLAFYQGLAWLRRELPALRSAVFRGYLGEGHLLAFFRGEPGEGEVLAAFNSGLEATPLPLPPGGWRDPLEGRTYRNQVEIPPLGFRYLVHSGG
>NC_017278|1694078:1759605|1758987_1759605_+|WP_081477232.1|integrase|DBSCAN-SWA
MGREEELAKILEAARQHRLFPLFYLAAAFGLRRGEVLGLTWPDIDLEKGELHIRRALVKDLASNKPILTGTKTPTSNRTIPLTEEAIAILEEHRQRLIDDGLYQPNGLVFPSLSGTPIRPENLKRAWKSILNKAGVKYARLHDLRGTFLTRVIRQTGNPKLAAALAGHKTLSTTLKHYTHISQEELKSTLRSLQVLPKDKDPEDN
>NC_017278|1694078:1759605|1732111_1732534_+|WP_155983288.1|DBSCAN-SWA
MGVLVLIGFDLDARNIGEVRRVIREVAQHLAFSFPSEALDQLAEALWDCPEFLEILTEIEDAPSPLLNRLATHPDPHVRAKVCGHPNASPDTLRQLYQQPDLPAWCLQALANNPNTPRDTLQKIAHDWKIPEALTRLQDP
>NC_017278|1694078:1759605|1734112_1735333_+|WP_014514494.1|transposase|DBSCAN-SWA
MFNRGAHLSTRRCPVDQDTLRILLREAVRETVAEVLQTVLELDRTAFLQVHGGRRNGYYPRKLETTFGQVDLKVPRDRESRYYPAFLKPYVRRLVDVGEVAVALYAAGVSQRKAAEILSLLLGHRYSHETLSALTDEVLEAAGAFRTRPLPEEMAFVYLDGLSLKVFREGEGIVRESVYVALGIAPNGERRVLGFWLLPTESALGWEGVLGELWQRGLRRVLLFITDGLPGLPEAIRRVYPQAEWQRCVVHGVRWSLSQVRARDRGLLAEDLRRVYGAESREEALGALEEVKAAWGSRYPGVVGLWVQDSGAFLRFYGYPKVLWPYLRSTNLMERFIREVRRGTKVRDHKFPKEEAVYKLLYLESERQEGRWAERKLKGFSEVKEVLEKMLQERYAPRTQTLTHNS
>NC_017278|1694078:1759605|1714807_1715854_+|WP_041433847.1|DBSCAN-SWA
MPEVRATSVAEVQEAVRLYPRLRPRGGGSKPALSTPREGEVGLDLSGLRGLLEYTPEEFVFTAYAGTPLSEVEEALKAHGQYLPFHPPLKGRGATLGGTVASGLSGPMRYRFGGLRDFLLGVRFVDGEGRLVRGGGKVVKNAAGFPFHRLMVGSLGAFGVVVELSFKVFPYPRVTRTLRVRLGSLGEALAALERLRSLPLDLLALDLLPPATLEVRLGGFPRSVEARLKGIQELLGQEGEVLEEDEAHWEAVRDLAFLEESPVWVKVPAGLGRLPELETLPLERRRYLAGGELLYAGTDPEGLKALRQRGLPHLVLRGAEEPLFPPPPQGFFARVKGALDPLGRFPLG
>NC_017278|1694078:1759605|1700638_1701532_+|WP_014516101.1|DBSCAN-SWA
MELSPTQDGFLGEIAKDFTFATVARLAGGVAARLAEEGLRRVVVAHDTRFLAKEMAEEAARVLAGAGLETHLLQGPAPFPLFAFALAEKEAAGFYLTASRKPAPYQGVKLRRGPGKPLSPEELSLPPSPPEGRGSFALLDLKKPYLERLAQSAGEMGEKGGVVYLDAMGGAGGGFLAGAFKRLGLGAELREIHPLPHPLFYGVDPNPVPENLNTLRVLLKALEPPGVGFALDGDADRLAVFLPGGEMLPSEGVLAHLREASAGREVQGDGEGGYLFPWHLPEKDAFLAALLLLKVLL
>NC_017278|1694078:1759605|1732596_1733217_+|WP_041434024.1|DBSCAN-SWA
MGEVLRQRRKELGLTLGQVAQALGTSDGYVWKLEQGLINLGNVPYHRLVALMKVFRWSPEEFAQATGVKVPGFTAEGVPGAPPVPLLKVPLVGAGAGAEAPASTEEPVEYLILGLPEVEVDPKDLRALAYKDGFVVYREGEEPEHGKLAVAVSKEGQKVRYPVRFLGLNTRKSFVVETLGCPSETRVLEKTEWALHRVVGQVKLED
>NC_017278|1694078:1759605|1702540_1704187_+|WP_014516103.1|DBSCAN-SWA
MHPWYAHYDPGVPQEAPKPWLLTELLRENARRYPEKVALEFLGRSISYQRLWRQVEAFARGLQEAGLEPGERVAIMLPNSPQFVIAFFGTLLAGGVAVNTNPMYTPRELRHQLLDSGAKALVILDLLLPRYQEVKAEAPVEVLVRTGIQDYLPFPKNLLYPLTLKRKGQWPKELEGIPWRAFLKAWKPEPVALDLDDLALLQYTGGTTGVAKGAMLTHRNLSTNALQVRAWIPDFREGEEVVLGAIPFFHVYGMTVAMNLALLGAAKLVLLPRPEIKPIVEAIEKHGVTLFPGVPTLYVAFNNFPGIEGRSLKSIRACISGSAPLPLEVAERFEKLTGAKLVEGYGLTEASPVTHCNPLYGPRKLGSVGLPFPGVEAKVVDEEGKELPPGEVGELILKGPNVMKGYWNRPEESQKTLKDGWLFTGDLAKMDPDGYFYIVDRKKDMIIAGGYNIYPREVEEVLYQHPAVQEAAVVGVPDPYRGETVAAFIVLKDEYKGKVSEKDIETFCRQNLAAYKVPRILQFRDTLPKSSVGKILKRELAKEVPRRA
>NC_017278|1694078:1759605|1704715_1705588_-|WP_014516105.1|DBSCAN-SWA
MTGERVVHVASPKAKLYAEADQAIRERLRAFPKALRAYELLIQDPEARAGWNMANYLTMRKLGYNDHGRVHALLTGAASVAILGLLAEAGVRLDTLESGAGELEDAYVVVLLSTMLHDLGNQVHREHHEAFGVTLALPILNRILEKIYPDPEQRTALRALILHGIHSHDLNPEPLTVEAGVTAVADGTDITKGRGRKAFALGSIDIHSISALAVDEVRILKGEKVPVEIQVTMNNSAGIFQVEETLTKKVLRSPLRPYVTVVAMTGEGGQDQRIVHRVRLHETEDRFVLD
>NC_017278|1694078:1759605|1707886_1708537_+|WP_014516109.1|DBSCAN-SWA
MPGNPLFQDLTPEEEALARTYFQSLAYPKGKHVFRQGDLGQSLYLVAEGRVRLYRTHLGGQEKTLGLVGKGGVFGEMSLLDGGERSASAVAEEDTLLLALHREAYLALIRRVPLLAHNLARILAHRLRELNVELDLLAFEEAESRVAYALLKLLRLGHGPRLRLRHQDLAALAGASRETVTRVLHGFKQRGLLRLAPGEVEVLDPGLLEEVAFGLA
>NC_017278|1694078:1759605|1742987_1743197_-|WP_014516132.1|DBSCAN-SWA
MSPERDTQEPFLARYAAEKGLQGRDVALGGSLYQDLEAQGFHEAQRYRKSPPHALAHGMRKEEALRALL
>NC_017278|1694078:1759605|1715858_1717127_+|WP_014516117.1|DBSCAN-SWA
MQHRIPVETLGPEGEVMAHAIEACVHCGFCLPTCPTYLVLQEEMDSPRGRIFLMKEVLEGNLGLEEALPYLDRCLACQACVTACPSGVPYGELIAAFRLHTEGKRHRYPLERAYRLALLRTLPYPGRFRPLAELGARLKPLLQPLPLPKPLKAPLELLPPRLEREEGYAEVYPAKGERKARVGLLLGCAQRVLRPSINRATIKVLQENGLEVLAVREQVCCGALNLHAGDKEGARALARQNLRAFREVDFVVTNAAGCGSGMKEYPLLFLGEAEEEEARHLAAKVKDLTAILAEVGFTPPPPPKKPLRVAYHDACHLAHAQGVREAPRRLLKAAGVEVLEPREWEICCGSAGTYNLFQPGIAEALGRRKAENLMATQPHLVVTGNIGCLTQIQAYLDPRIPILHTAELLALLYEGQAENLPA
>NC_017278|1694078:1759605|1710976_1711801_-|WP_155983287.1|DBSCAN-SWA
MSRDEMVFRLLKNTLGDASLGFMPRPRERGAGEVKTLERGLKVLEALAELGEGGLSPLARRTGLSKSTLYRLLQALVRLGFVEEVEGVYRVGPRAFAVGQAYLRKSLLQAVRPEMEALAAETGESVNLAVPAGMEALYLDQAEGTKLVRLFTAPGSRAPLHATGVGKVLLAYRGVPEGLPLTPYTPFTLTRREDLLRELERVRRQGYALDNEEKELGVRCVAAPVFGPGGEVVAALSLSAPASRLSPQAAHALAPRVLEAARRASLRLGFTPTL
>NC_017278|1694078:1759605|1738412_1739504_+|WP_014514485.1|transposase|DBSCAN-SWA
MEQLTPLINALKRYWKADLRRLTFLAALVMALVTARTTSGPRLALSLGSIASPDPRSAYRRFQRFLAWPGLDGEGYARFIFALLRPQGLLLVMDRTEWELGKSKVNLLMLAFLYQGLAVPLFWSFLPHDGNSSTPERIALMERALAFLRAHFPHLRVEGFLADREFIGEAWFRYLEEKGIPRCIRIKANTRMWRLGSGPRAWELFASLKVGESRVPRRRYWVYGRRMWVVGLRLGVREWLIVATDLDPHRVLEVYGLRWGIERLFGALKGRGFDLEATHVTRGERLSRLLVPLSLAFVWAFRTGLVLHRVRPVRPKKHGRLGQSLFRAGLDLLTLWALALWGAGGGRRGSPLGLCPMEVLTCT
>NC_017278|1694078:1759605|1756336_1756576_-|WP_014516141.1|DBSCAN-SWA
MGGKFEGKVKITEELLFDEEFIAELKRRRETLGVSATRFARMLGLRPHWVLRVEQGKDYLARKPYYLVKRYLRALGFDE
>NC_017278|1694078:1759605|1745698_1745962_+|WP_050802042.1|DBSCAN-SWA
MAYMVKKVHSTTLTVDAQGRVLLPSPLRRALGLRPGTRLVALVEEGRLVLEPWERVEEALWEELSDIKESLTEELLRERRLEAERDA

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014516094.1|1694078_1695494_+|tRNA	glutamate--tRNA ligase	NA	NA	NA	NA
WP_014516095.1|1695528_1695969_+	hypothetical protein	NA	NA	NA	NA
WP_014516096.1|1695968_1696883_+	signal recognition particle-docking protein FtsY	NA	NA	NA	NA
WP_041434017.1|1697056_1697464_+	disulfide bond formation protein B	NA	NA	NA	NA
WP_014516099.1|1697765_1698479_-	hypothetical protein	NA	NA	NA	NA
WP_041434018.1|1698489_1700577_-	AAA family ATPase	A7KV33	Bacillus_phage	8.7e-113	38.4
WP_014516101.1|1700638_1701532_+	phosphoglucomutase	NA	NA	NA	NA
WP_014516102.1|1701528_1702482_+	MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_014516103.1|1702540_1704187_+	long-chain fatty acid--CoA ligase	A0A2H4PQM9	Staphylococcus_phage	1.5e-35	26.4
WP_014516104.1|1704284_1704719_+	DUF2267 domain-containing protein	NA	NA	NA	NA
WP_014516105.1|1704715_1705588_-	phosphohydrolase	NA	NA	NA	NA
WP_014516106.1|1705656_1706472_-	3-hydroxybutyryl-CoA dehydratase	NA	NA	NA	NA
WP_014516107.1|1706475_1707183_-	purine-nucleoside phosphorylase	NA	NA	NA	NA
WP_014516108.1|1707208_1707838_-	ATP-binding cassette domain-containing protein	G9BWD6	Planktothrix_phage	1.9e-31	39.3
WP_014516109.1|1707886_1708537_+	Crp/Fnr family transcriptional regulator	NA	NA	NA	NA
WP_014516110.1|1708558_1709290_+	2-phosphosulfolactate phosphatase	NA	NA	NA	NA
WP_014516111.1|1709286_1710600_-	dipeptidase	NA	NA	NA	NA
WP_014516112.1|1710596_1710935_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_155983287.1|1710976_1711801_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_014516114.1|1711833_1713396_+	malate synthase A	NA	NA	NA	NA
WP_014516115.1|1713435_1714821_+	FAD-binding protein	NA	NA	NA	NA
WP_041433847.1|1714807_1715854_+	FAD-binding protein	NA	NA	NA	NA
WP_014516117.1|1715858_1717127_+	4Fe-4S dicluster domain-containing protein	NA	NA	NA	NA
WP_014516118.1|1717123_1718347_+	DUF4147 domain-containing protein	NA	NA	NA	NA
WP_041434020.1|1718360_1719482_+	radical SAM family heme chaperone HemW	NA	NA	NA	NA
WP_014516122.1|1719901_1720291_-	NADH-quinone oxidoreductase	NA	NA	NA	NA
WP_014516123.1|1720370_1723322_+	AAA family ATPase	NA	NA	NA	NA
WP_041433848.1|1723359_1723539_+	hypothetical protein	NA	NA	NA	NA
WP_081477229.1|1723626_1726746_+	hypothetical protein	NA	NA	NA	NA
WP_081477230.1|1726772_1727612_+	alpha/beta fold hydrolase	NA	NA	NA	NA
WP_014516126.1|1727762_1730456_+	hypothetical protein	NA	NA	NA	NA
1730515:1730560	attL	NA	NA	NA	NA
WP_014514494.1|1730633_1731854_-|transposase	IS256 family transposase	NA	NA	NA	NA
WP_155983288.1|1732111_1732534_+	hypothetical protein	NA	NA	NA	NA
WP_041434024.1|1732596_1733217_+	helix-turn-helix domain-containing protein	Q859R0	Thermus_virus	6.5e-08	38.2
WP_014516129.1|1733605_1733917_-	hypothetical protein	NA	NA	NA	NA
WP_014514494.1|1734112_1735333_+|transposase	IS256 family transposase	NA	NA	NA	NA
WP_041433850.1|1735240_1736863_-	hypothetical protein	NA	NA	NA	NA
WP_014514494.1|1737098_1738319_-|transposase	IS256 family transposase	NA	NA	NA	NA
WP_014514485.1|1738412_1739504_+|transposase	IS4 family transposase	NA	NA	NA	NA
WP_014516132.1|1742987_1743197_-	peptidase C26	NA	NA	NA	NA
WP_014516133.1|1743436_1745554_-	alpha-amylase	NA	NA	NA	NA
WP_050802042.1|1745698_1745962_+	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	NA	NA	NA	NA
WP_014516135.1|1745954_1746341_+	type II toxin-antitoxin system VapC family toxin	NA	NA	NA	NA
WP_014516136.1|1746371_1747127_+	carbohydrate ABC transporter permease	NA	NA	NA	NA
WP_014514494.1|1748421_1749642_-|transposase	IS256 family transposase	NA	NA	NA	NA
WP_014516139.1|1751090_1751624_-	hypothetical protein	NA	NA	NA	NA
WP_003043751.1|1751824_1753021_-	MFS transporter	NA	NA	NA	NA
WP_014632236.1|1753013_1754489_-	radical SAM protein	NA	NA	NA	NA
WP_014516140.1|1754754_1756239_-	hypothetical protein	NA	NA	NA	NA
WP_014516141.1|1756336_1756576_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_081477232.1|1758987_1759605_+|integrase	site-specific integrase	A0A1B0T6A8	Bacillus_phage	2.4e-18	31.8
1759675:1759720	attR	NA	NA	NA	NA

Sequences of DBSCAN-SWA_2

Nucleotide sequences of DBSCAN-SWA_2

>NC_017278|2234169:2241253|DBSCAN-SWA
TTCATTCCTCCTCCATGGTTTCTGAAGACGCCAAAGAAAGCCGGTAGGCCTCGTTCCGGGGTACCCCCCGCTCCAGGAGGGCCCGGAAGAGGGCCTTGCCCCTAAGCCCCTGGGCCCTTAGGGCCTGGGCCAGCCCCTGGCCCTCGGGGAGGGGGGCCTCCTTGGGTCCCAGGACCAGGACGAACTCCCCCCTGGGCTCGCCAAAGTGGGCCAGGGCCTCCTCCAGACTCCCCCGGAAGACCTCCTCGTGCACCTTGGAGAGCTCCCGGGCCACGGCCACGGGGTGGCGGGGCCCGTACACCTCCCGCAGGTCCTCCAGGGTCTTGCGCAGGCGGTGGGGGCTTTCGTAGAGCACCGCCGTCCTCCCTTCCCGCGCCAGGGCCCAAAGCCGCTCCCGGCGCTCCTTTCCCCCCTTGGGCAGGAAGCCCTCAAAGGTGAAGCGGTGGGTGGGCAGGCCCGAGGCCACCAGGGCGGGGATGAGGGCCGTGGGGCCGGGAAGCGCTTCCACCCGCCAGCCCCATTCTAAGGCCATACGGACCAGCTCCGCCCCGGGATCGGAGATCCCCGGGGTACCGGCGTCGGTGGCGTAGGCCACGTGGGCGTACGGGGCCAGGAGCTCCTTGGCCCGGCCCAGGGTGTGCTGGTCCAGGCGCAGGGTGGGCGTGGGGATGCCGTAGTGGCGGAGGAGAAGCCCGGTGCGCCGCGTGTCCTCGCAGGCCACCACCTCCGCCTCCCTTAGGGCCCTTAGGGCCCGCAGGGTGATGTCCTCCAGGTTGCCGATGGGGGTGGGGACCAGGACCAGGCGCACGCTAGAGGAGGAGGGGGCGGAGGAGGTCCTGCACCGCGCGGAAGGGGAACTCGTAGACCGAGCCGGAGGGGAGGGTGAACTCCAAGAGGTCCTCCGCCCCGGGGAAGAGGATGCGCCGCAGGGCCAAGGGGCCCTGGTCGCTTTCCAGGTGCACCGTCAGGTAATCGGGCTCCAGGTTGGGCTCGTCCTCGGCCTCCTTGGGGGGCTCCTCCCCCAGGCCCTCCTCTAGGCGGCGCAAGGCCTCCAGGAGTTCAGCCTTGGAGAGGCGCACCTCCTCCTCCAGGGCCCCGTCGGAAAGGACCAGGACCGCCTCCTCGCCCTCGCCATAGGCGGAAAGCCCCCAAAGGGCCTCGGCCTCGCCCTCCTCGCGGGCCTCCACCAGCTCCAGGCTGCCGTCGGAAAGGATGCGGAGCAGGGCGCCGCACGCCTCGCAGTCCACCAGCTCCCCCGCCTCGTACCCTTCCCGCTCCAGGGGTTCCCCGCAAACCGGGCAGACCATAAGGGCTCCTCCGGGGCCATTGTACAGGCAAAAGGCTTCAGGCCCCGTAGCGGGCGATGCAGGCCCGGACCTCTTCCAAGGCGGCCTGCCGGTCGCGCCAGCCCGTCACCTTGACCCACTTCCCCTTCTTGGCCTCGAGGGCCTTGTAGGTCTCAAAGAAGTGCTGGATCTCCTGCTTTACCCCCTCGGGCACGTCGGCGATGTCTTGGATGTGGTCTAAGCGCTGGTCCTCGGCCACCACCCCGATCACCTTGGCATCTCCCCCCTTCTCGTCCTCCATGAGGAGGAGGCCCACCACCCGCACCTCCACCACCACCCCGGGCAGGAGGGGGTAGGTGGAGAGGACAAGGCCGTCCAGGGGGTCCCCGTCCTCGGCCAGGGTGGAGGGGATGAAGCCATAGTCCCCGGGGTAGAACTGGGCTCCGGGGAGAACCCGGTCCAGCTTGATCACCCCCAGCTCGGGGTCGTACTCGTACTTGTTCCCGGAACCCCGGGGGACCTCGATGACCATGTGGACCACTTCCGGCGCGCCTTTGCCCACGGGAAGGCTCTTCAGGTTCGCCATAGCCCCCCCATTATACGAGGACCTCCGGAAGATCGCTCACCAAAGCGTCCACCCCCCAAGCCGCCAGGGCCTCGGCCCTCGGGCGCGCGTTCACCGTCCAGGCCAGGATGCGGTACCTCCCCTTGAGGGCCTTCACCCGCTCCTCGGTGAGCAAGGAGGCCTCGGGGTGCAGCCACTCCACCCCCAGGCAGGGGGCCAGGGCCTCGGCCTCCGGGCGCTGGTAGAGGAGGCCCAAGGGGCCCACCCCCAGCCGCCTCAGCCGCACCAGGGCCAGGGGGTCAAAGGAGCTCACCCAGATCCGCTCCGAGGGATAACGGGCAAGGAGCCCGGCCAAGGCCTCCTCCCGGCCATCCGTCTCCGGGGGCAGGCTCTTGAGCTCCACGTTGATCCAAGCCCCGGGAAAGGCCTCGAGCACCTCCTCCAGGGTGGGCACGTAGGCGGGAAGCTCCCTACGGGTGAGGGAGGCCAAGGGAACCCCCCCCAGGGCAAAATCGTGGAACACCACCAGGACCCCATCCCGGGTGAGGTGCACGTCCAGTTCAAACCCGTCCAGGCCCGCCTCCAAGGCTTTCCTAAAGGATTCCAGGGTATTCTCCCGCGCCCTCTTGGGGGCGCCGCGGTGGCCTAAGCGCAGGGGCACGGGCCGAGTATACAATGGGGTCATGGGCAAGTATGAAGCGGCCTTTTCCCGCCTGGGGGAGCGGGCCCTGGCCCAGCTGGAGGGCCCGGGAGGATTTTTGGCCGTTACCGAAACCCATCTGATCCTGGTGGACGAGGAGGGCGTGAAGCGCCTGGAACTGGCCCGCATCCGCCGGGTGGGGCGGGGGGAGGCGGGCACCCTGGCGGTCCAGGGGGAGGCCGAGGCCCTGGCCATCCCCCTCAAGGCCTTTCCCCTGGAGGAGCTCAAGGCCTTCCTGGAGGGGCTGAAGCCCCACGTGGCCCGGGCCCGGAAGGCCACGGCCACCCCGCCCCCAAGGGGGGAAGCGCCCCCGCGGCCAGCCCCCCCGCCGCCGAGCCCGGCCCCAACCCCCAGGGAGGAGGCCTCGAGGCCTTCCCTCTGGGAGGAGGAACCCCCCCCCAAGCGGGCCTCCGTGGAGCTGGCCCCCGAGCCGGAGCCGGTCCCTCCCCCAGCCCCGGCGGAAGCCCCAAAGGAGAAGGGGAGGCAGCGCAACCCTTTGGCCCTTCCCCTCAAGGCGCTCTCCCTCCTCACCCTGGGCTACACCCTGGGCTTCGTGGCCCTCAACCCGGGGGCCGACCCCTGGGCCCTGGCCGGGGTGGTCCTGGGGGGGATCGGCCTGGCCTTGGCGGAGTGGTCCTTGGCTACCTCCTGGCGGTAGCCCTCCTGGGCCTCCTGGCCCTGTGGCCCAAGGTGGCCCCGGGACCCGGCCCCGTGGCAGTGGAGGTCTGGGCAGAGCCCCGCTTCACCCCTCCACCCCCGGAGCCCATCAGCCTGAACCGGGCCAGCCTGGAGGAGCTGGAGGCCCTGCCCGGTATCGGCCCCACCCTGGCGCGGAGGATCGTGGAGGGCCGGCCTTACGGGAAGGTGGAGGACCTCCTGCGGGTGAAGGGGATCGGGCCGGCCACCCTGGAGCGGCTCCGACCCTACGTGCGCCCCTGAGATGCAAAGGGCCCCCAGGCATCCCCTAGCCCCAGCCCTGGGGTGGGGGATGGGCCTGGGGGTAGGGGGGGTTCTGGGGGCTTGGGGGCTGCTCCAGCCCTGGGCCTTGGCCCTGGCCCTGCCCCTGCTTCCCTTCTTCCGCCTTCCCCTGGCCCTGGGCCTGGCCCTGGTGGCCCTCCGCGGCGCCCTCCTGCCCCTCCCCGAGCCCCCTTTTGGCCTGCGGCTGGAAGGGGTTTTCCCGGTGGAAGGGGGGTTTACCGCCTGGGAAGGGCACCGCCTTTGGGTGCGGCATTACCCGCCCCTGGAGGACGGCCTCTACCGCCTCCGGGGGTATTTGGCTCCCCCCGAGGACCGGCGCAACCCCGGGGGGGTGGACCTGCGGGCCTGGCTCCTGGCCCAAGGGGTGAAGGGGGTGTTTCACGTGGAACGGGCGGAGGCCCTAGCCCCCCTGGGGGATCCCCGGCGGCCCCTACGGGAACGGCTGGCCCAGGGGCTCTCCCCCCCGGTCCGGGAGGTGGCGGAGGGCCTGGTCCTGGGGGACAAGGAGGGTTTGGAGGAAACCTACCCCCTCTTCCAGCGGGCGGGGCTGGCCCACCTCCTGGCCCTCTCCGGGCTGCACGTGGGCTTCCTGGTGGGCAGCGTCCTCCTCCTTCCCTTGGGCCGCGGGCGCTACCTCCTGGCCCTCCTCCTCCTGCCCCTTTACCTTTGGCTGGCGGGGCCTAGCCCTTCCCTGGTCCGGGCCAGCCTCATGGCGGGCCTCTCCCTCCTGGGCCTCTTCCTGGGCTTAGGGGGGGCAGGGGTGCTGCAGGCCTTGGGCCTGGCCCTCTTCCTCCAGCTCCTCCTCCGCCCCGAGGCCCTCCTAAGCCTCGGCTTCCAGCTCTCCCACCTAGCCGTGCTGGGGATCGCCCTCATCCTCCCCTGCCTGCCCCCTTGGAAGGGGGTAAGGGGGTACCTCCTGGGGGCCTTCCTCACCACCCTGGCGGCCCAGGCCCTCCTGGTCCCCCTCCTCCTCCACCGCTTCGGCTTCCTCCCCCTCCTTTCCCCCCTGACCAACCTCCTGGCCCTGCCCCTGGTGGCCCTCCTGGTACCCCTGGGCTTCCTCAAGCTCCTCCTGGGTGGCCTCCTGGCCCCCTTGGTGGAACCCCTGGGCCGGGGGCTTCTCCTCTTGGCCCAGGTGGGAAGCCACGGGCCCCTCCTGCGCTGGGGGGAGATCGCCCCCCAGGGGTTTGGCCTTTATTACCTGGCCCTCCTACCCCCCTTCCTGGCCCTCCATCGCCTCCTTCCCTGGCGGAAGGCCCTGGTCCTGGCCAGCTTTCCGGTCTTGGCGGGGCTTCTCGCCGCATGGCCCAAGCCCCTGGACCTCTGGGCCCTGGATGTGGGCCAGGGGGATGCCCTCCTGGCTCGGATGGGCGGGGCCGAGGTCCTGGTGGACGGGGGGCGGCCCGAGCAGGGGGCAAGGGTGGTACGGGCCCTAAGGGCCCTAGGGGTGGAGGCCCTCGAGGTCCTGGTGGCCACCCATCCGGACGCGGACCATTTTGGCGGCCTGGGCAAGGTGGTGGAGGAGGTGCCCGTGGGCCTGGCCCTCCTCTCCCCCGCCTTCCGCCGGGACCACCCCCTGGTCCAGGCCCTGAAGGCCCGGCGCATCCCCATCCTTTACCCCGGCAGGGGGACGCGGCTAGGGGTGGGGAGGGGGCGCCTCGAGGTCCTCTGGCCCCCCGGCCCAAGCGGCCAGGACGACCGGGACGGCCTGGTCCTCCTCCTGGACTTTGGCCGGGCCAAGGCCCTCCTCCTGGCGGACGTACCCCAGGGGGTGGAGGCCCAGCTCTTCCCCGGCCCGGTGGAGGTCCTCAAGGTGAGCCATCACGGCTCCCGTACCGGCACGGCGGAAGCCCTTCTGCAAAGGGCCCGCCCGGCCGTGGCCCTCATAGGGGTGGGGAGAAACCCCTTCGGGCACCCCCACCCCGAGGTGCTGGAACGCCTGGCGGCCCACGGGGTACGGGTGTACCGCACGGACCTGGCGGGGGCGGTGCGGGTCCGCTTCGGCTACGCCTGGTAGCCGAGGCGCCGCAACAGGGCCTCCAGCTCCTCCAGGGAGCGGTAGTGGATCACCACCTTCCCCCGCTTCCCCCCCACCACCCGCACCGGCAGGCCCAGGTGGCGGGATAGCTCTAGGGCCAAGGGGGAGTCTTCCCGAGGCCTAGGGGCCCGTTCCCGCAGGAGGCGTTCCCTTAGGGCCTCGGCCTGGCGGACGGAAAGGCCCTTCTCCAGGATCTCCCGCAACCCCCAAAGCCGGTCCTCCGGCTCCAGCATCAGAAGGGCCCGGGCGTGGCCGGCGGAGATCTCCCCCCTTTCCAAGGCCTCCAGGGCCTCCTGGGGCAGCTGAAGGAGGCGGAGGGCGTTGGCCACGGTGGAGCGGGCCTTGCCCACCCGCTTGGCCACCTCCTCCTGGGTGAGGCCCATGGCCAGGAGGGCCTGGTACCCCCGGGCCTCCTCCACGGGGTTGAGGTCCTCCCGCTGCAGGTTTTCCACCAGGGCCAGCTCTAGGGCCTCCTGGTCGCTCAGGTCCCGGATCAGGACCGGAACCTCCCCCAGGCCCGCCATCTGGGCGGCGCGGTAGCGCCGCTCCCCGGCCACCAGCTCGTACCCCTCGCCCTTAGGCCGCACCAGAAGAGGCTGGAGAAGCCCCTTTTCCCGAATGGAGGCGGCGAGCTCCTCCAGGCTTTCCTGGGAAAAGCGGCGGCGGGGCTGCTGGGGGTTGGTGCGGATGGCCGTCAAGGGGAGGCGGACCACCCCCCCAGGGGTCTTGGGCAACAGGGCCTCCAGCCCCCTCCCTAGACCGCTAGGCTTCTTGGACACGGGCGATCACCTCCTCGGCCAGGCGGCGGTAGGCGTGGGCCCCGGGGGAGGTGGGGGCGTGCTGGGCGATGGTCTTGCCGAAGCTGGGGGCCTCGGCCAGGCGCACGTTACGGGGGACCACCGTCCAGAACACCTTCTCCCCGAAGTGGGTCCGGAGCTGGGCCTCCACCTGCTGGGAAAGCAGGGTGCGGCCATCGTACATGGTGATGAGGATGCCCAGGAGCCGAAGACCGGGGTTCAGGCGGGCCCGCACCTCCTCCAGGGTGGCCAGGAAGCCCGCCACCCCTTCCAGGGCGTAGTACTCCGCCTGGACGGGCACGATCACCCCCTGGGCTGCCGCGAGGGCGTTGAGGGTCAGGGGGGAGAGGCTTGGGGGAACGTCCAGGAGGGTGAAGTGGTAGGCCTCGTCCCGAAGGGCTTCCGCCAGGGCCAGGGGAGCCTCGGCCAGCTCCACCGTGGCCCCCACCAGCTCGGGGGTGGAGGGGAGGAGGTGGAACCCATCCGCCTCCCACACCAGGCTTTCCAAGGCCTCCCCCTGGAGGAGTTGGTACACGCCCCGTTCCGGACGCAGGCCTAGGCCGCTGGTGGCGTTGCCCTGGGGGTCCAGGTCCACCAGGAGGACCCGCCAGCCCATGCGGGCCAGGTAGGCCGCCAGGTTCAGGGCGGTGGTGGTCTTCCCCACCCCTCCCTTTTGGTTGACTAGGGCGATCCGCCGCACCTTGGCCTTAGCATAAGGGAT

Protein sequences of DBSCAN-SWA_2

>NC_017278|2234169:2241253|2239701_2240514_-|WP_014516641.1|DBSCAN-SWA
MSKKPSGLGRGLEALLPKTPGGVVRLPLTAIRTNPQQPRRRFSQESLEELAASIREKGLLQPLLVRPKGEGYELVAGERRYRAAQMAGLGEVPVLIRDLSDQEALELALVENLQREDLNPVEEARGYQALLAMGLTQEEVAKRVGKARSTVANALRLLQLPQEALEALERGEISAGHARALLMLEPEDRLWGLREILEKGLSVRQAEALRERLLRERAPRPREDSPLALELSRHLGLPVRVVGGKRGKVVIHYRSLEELEALLRRLGYQA
>NC_017278|2234169:2241253|2240497_2241253_-|WP_041434065.1|DBSCAN-SWA
MPYAKAKVRRIALVNQKGGVGKTTTALNLAAYLARMGWRVLLVDLDPQGNATSGLGLRPERGVYQLLQGEALESLVWEADGFHLLPSTPELVGATVELAEAPLALAEALRDEAYHFTLLDVPPSLSPLTLNALAAAQGVIVPVQAEYYALEGVAGFLATLEEVRARLNPGLRLLGILITMYDGRTLLSQQVEAQLRTHFGEKVFWTVVPRNVRLAEAPSFGKTIAQHAPTSPGAHAYRRLAEEVIARVQEA
>NC_017278|2234169:2241253|2237659_2239714_+|WP_014516640.1|DBSCAN-SWA
MQRAPRHPLAPALGWGMGLGVGGVLGAWGLLQPWALALALPLLPFFRLPLALGLALVALRGALLPLPEPPFGLRLEGVFPVEGGFTAWEGHRLWVRHYPPLEDGLYRLRGYLAPPEDRRNPGGVDLRAWLLAQGVKGVFHVERAEALAPLGDPRRPLRERLAQGLSPPVREVAEGLVLGDKEGLEETYPLFQRAGLAHLLALSGLHVGFLVGSVLLLPLGRGRYLLALLLLPLYLWLAGPSPSLVRASLMAGLSLLGLFLGLGGAGVLQALGLALFLQLLLRPEALLSLGFQLSHLAVLGIALILPCLPPWKGVRGYLLGAFLTTLAAQALLVPLLLHRFGFLPLLSPLTNLLALPLVALLVPLGFLKLLLGGLLAPLVEPLGRGLLLLAQVGSHGPLLRWGEIAPQGFGLYYLALLPPFLALHRLLPWRKALVLASFPVLAGLLAAWPKPLDLWALDVGQGDALLARMGGAEVLVDGGRPEQGARVVRALRALGVEALEVLVATHPDADHFGGLGKVVEEVPVGLALLSPAFRRDHPLVQALKARRIPILYPGRGTRLGVGRGRLEVLWPPGPSGQDDRDGLVLLLDFGRAKALLLADVPQGVEAQLFPGPVEVLKVSHHGSRTGTAEALLQRARPAVALIGVGRNPFGHPHPEVLERLAAHGVRVYRTDLAGAVRVRFGYAW
>NC_017278|2234169:2241253|2237349_2237658_+|WP_014516639.1|DBSCAN-SWA
MVLGYLLAVALLGLLALWPKVAPGPGPVAVEVWAEPRFTPPPPEPISLNRASLEELEALPGIGPTLARRIVEGRPYGKVEDLLRVKGIGPATLERLRPYVRP
>NC_017278|2234169:2241253|2236050_2236680_-|WP_014516637.1|DBSCAN-SWA
MPLRLGHRGAPKRARENTLESFRKALEAGLDGFELDVHLTRDGVLVVFHDFALGGVPLASLTRRELPAYVPTLEEVLEAFPGAWINVELKSLPPETDGREEALAGLLARYPSERIWVSSFDPLALVRLRRLGVGPLGLLYQRPEAEALAPCLGVEWLHPEASLLTEERVKALKGRYRILAWTVNARPRAEALAAWGVDALVSDLPEVLV
>NC_017278|2234169:2241253|2234169_2234976_-|WP_014516634.1|DBSCAN-SWA
MRLVLVPTPIGNLEDITLRALRALREAEVVACEDTRRTGLLLRHYGIPTPTLRLDQHTLGRAKELLAPYAHVAYATDAGTPGISDPGAELVRMALEWGWRVEALPGPTALIPALVASGLPTHRFTFEGFLPKGGKERRERLWALAREGRTAVLYESPHRLRKTLEDLREVYGPRHPVAVARELSKVHEEVFRGSLEEALAHFGEPRGEFVLVLGPKEAPLPEGQGLAQALRAQGLRGKALFRALLERGVPRNEAYRLSLASSETMEEE
>NC_017278|2234169:2241253|2235512_2236040_-|WP_014516636.1|DBSCAN-SWA
MANLKSLPVGKGAPEVVHMVIEVPRGSGNKYEYDPELGVIKLDRVLPGAQFYPGDYGFIPSTLAEDGDPLDGLVLSTYPLLPGVVVEVRVVGLLLMEDEKGGDAKVIGVVAEDQRLDHIQDIADVPEGVKQEIQHFFETYKALEAKKGKWVKVTGWRDRQAALEEVRACIARYGA
>NC_017278|2234169:2241253|2234977_2235475_-|WP_014516635.1|DBSCAN-SWA
MVCPVCGEPLEREGYEAGELVDCEACGALLRILSDGSLELVEAREEGEAEALWGLSAYGEGEEAVLVLSDGALEEEVRLSKAELLEALRRLEEGLGEEPPKEAEDEPNLEPDYLTVHLESDQGPLALRRILFPGAEDLLEFTLPSGSVYEFPFRAVQDLLRPLLL
>NC_017278|2234169:2241253|2236702_2237377_+|WP_014516638.1|DBSCAN-SWA
MGKYEAAFSRLGERALAQLEGPGGFLAVTETHLILVDEEGVKRLELARIRRVGRGEAGTLAVQGEAEALAIPLKAFPLEELKAFLEGLKPHVARARKATATPPPRGEAPPRPAPPPPSPAPTPREEASRPSLWEEEPPPKRASVELAPEPEPVPPPAPAEAPKEKGRQRNPLALPLKALSLLTLGYTLGFVALNPGADPWALAGVVLGGIGLALAEWSLATSWR

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014516634.1|2234169_2234976_-	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	3.9e-37	38.5
WP_014516635.1|2234977_2235475_-	hypothetical protein	NA	NA	NA	NA
WP_014516636.1|2235512_2236040_-	inorganic diphosphatase	A0A2H4J8U1	uncultured_Caudovirales_phage	6.5e-33	46.5
WP_014516637.1|2236050_2236680_-	glycerophosphodiester phosphodiesterase	M1HE48	Acanthocystis_turfacea_Chlorella_virus	6.0e-09	29.6
WP_014516638.1|2236702_2237377_+	hypothetical protein	NA	NA	NA	NA
WP_014516639.1|2237349_2237658_+	helix-hairpin-helix domain-containing protein	NA	NA	NA	NA
WP_014516640.1|2237659_2239714_+	DNA internalization-related competence protein ComEC/Rec2	Q0H255	Geobacillus_phage	7.1e-27	33.3
WP_014516641.1|2239701_2240514_-	ParB/RepB/Spo0J family partition protein	I3NLC2	Bifidobacterium_phage	3.6e-22	39.9
WP_041434065.1|2240497_2241253_-	ParA family protein	Q8JL10	Natrialba_phage	3.8e-18	33.1