CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_016593	Geobacillus thermoleovorans CCB_US3_UF5, complete genome	5 crisprs	c2c10_CAS-V-U3,cas14k,csa3,RT,DEDDh,cas3,DinG,cas14j,Cas14u_CAS-V	1	9	15	1

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_016593_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016593_1

394989-398364

Orphan

Consensus_repeat	Method
GTTTTTATCGTACCTATGAGGGATTGAAAC	PILER-CR
GTTTTTATCGTACCTATGAGGGATTGAAAC	CRISPRCasFinder
GTTTTTATCGTACCTATGAGGGATTGAAAC	CRT

50 spacers

The CRISPR arrays of NC_016593_1

>merge|NC_016593|1|394989-398364|PILER-CR,CRISPRCasFinder,CRT
GTTTTTATCGTACCTATGAGGGATTGAAACTTGTTGCCCCTCCCCGAACACTTCCTCAACCTGCTCCAAGTTTTTATCGTACCTATGAGGGATTGAAACCTCCGCGTAATTCGCTGTCTGTTTGCGTTTGCGCCGGGTTTTTATCGTACCTATGAGGGATTGAAACAATCCTCCGTGATGTTTCCATAGCGAACGGTCTTGCTGTTTTTATCGTACCTATGAGGGATTGAAACTTTCATTCATCATTCTACGTACTTAGACGACGAAAAGGTTTTTATCGTACCTATGAGGGATTGAAACACATGGGCAGTCGGCAACGCGGTGACACGAAAAGACGTTTTTATCGTACCTATGAGGGATTGAAACCAACAAAGAGTCCGACGACGATACGCTTGAGATCATCGTGTTTTTATCGTACCTATGAGGGATTGAAACCTTTTTGCAACGTCCGGGACCGCAAAAACGATAGGTGTTTTTATCGTACCTATGAGGGATTGAAACGCAATACCTTTGAATCCAACCTTGCTGGATAAAGGTTTTTATCGTACCTATGAGGGATTGAAACTTTGGTCCATGATCGAAAAGATAATAAACGGCGCCGACTGTTTTTATCGTACCTATGAGGGATTGAAACTTCGTTGGATGACGTCGAGATTGTCACGGTTCCGTCGTTTTTATCGTACCTATGAGGGATTGAAACGGTTCTTGTGACAGAATGCCAACTTGTACAGCGGCATTGTTTTTATCGTACCTATGAGGGATTGAAACGCAGCGCCGGTTGTCGAGGTGTACCTTGCGATTGAGTTTTTATCGTACCTATGAGGGATTGAAACCGGCGACAACGGGAAACGAATCATTACGGACATAATCCGTTTTTATCGTACCTATGAGGGATTGAAACCACTTGTAGAGCTAGAAGGTTCCCTTCGGAATACGATGGTTTTTATCGTACCTATGAGGGATTGAAACGATTGGTGAACTCCGGTCTTACCGCGGTGATGCTCCGTTTTTATCGTACCTATGAGGGATTGAAACGTTGGTATCTGCGAAGTGGTCGCGTATCCAACGTCGTTTTTATCGTACCTATGAGGGATTGAAACCCGTGGCAACCGTGGTACATGGAACTATTCGGAAATAGTTTTTATCGTACCTATGAGGGATTGAAACAACTGGTGGCAGGAGCAAATATTTCTCTTACTCCAGACGTTTTTATCGTACCTATGAGGGATTGAAACTGCACCAAAATAGACCTGGCGATGACGCTAAGGAAGTTTTTATCGTACCTATGAGGGATTGAAACTTGAATCCCGTTGATTATGTACAACGCCAAGTGCTGAAAAGTTTTTATCGTACCTATGAGGGATTGAAACCAAGCATTGGAGGGAAAAGAATGATCTACATCTTGCGTTTTTATCGTACCTATGAGGGATTGAAACTCGCTGAAACAGCTGACTCGGTACAGTGAAGCCGAGTTTTTATCGTACCTATGAGGGATTGAAACACACAACGGTACGGACATATCAGCTGACGCCGGAGCGTTTTTATCGTACCTATGAGGGATTGAAACTCCACGCTTGTAGTGAAAACAACAGCCGGAACTACGTTTTTATCGTACCTATGAGGGATTGAAACGCCGAGGCCGAGGCGAAAGCGTTGGTGAAACTATTGCCCAGTTTTTATCGTACCTATGAGGGATTGAAACGCATCTCGTTCCGGATGCGTGTCAGCACATTCAGCACATGTTTTTATCGTACCTATGAGGGATTGAAACAGGCTCGCTATGGCTACGACAACATCAGTGGAATACGTTTTTATCGTACCTATGAGGGATTGAAACTTATATCATCATTTGGTGATTTGTAAACATCTTTTCGTTTTTATCGTACCTATGAGGGATTGAAACCAATCTCAAAAACTCGGTTGCGATCATCGAGCGATGTTTTTATCGTACCTATGAGGGATTGAAACCGTTTCCCAGCTCGAAAAAGTGGCGCAGAAGCAACAAAGTTTTTATCGTACCTATGAGGGATTGAAACCTATTTCCCCAAGCGTGTGCTGGCACGCTGCAAGCATAGTTTTTATCGTACCTATGAGGGATTGAAACCATTCGATATATGGACGACGTCATTGTACTGCACGAAAGTTTTTATCGTACCTATGAGGGATTGAAACACCAAACAACTCAACCAATTTTTTAAAACTAATTCCCGTTTTTATCGTACCTATGAGGGATTGAAACACCGTCTACCCATTCAACAAGAAAGGCTGTTTTTCTGTTTTTATCGTACCTATGAGGGATTGAAACTAAGCGTCTGTCAATGTTTCTTGACGTTCGCTTTCGTTTTTATCGTACCTATGAGGGATTGAAACTCTATGAAACCCTTCGTACCGAAGAGAAACAGCGGTACTAGTTTTTATCGTACCTATGAGGGATTGAAACTGATCGCTCTGGCCGCAGTTAACTTATTAAATTTATCGAGTTTTTATCGTACCTATGAGGGATTGAAACTGAAAATCAGCAGATATTGCAAAAGCTCGAGGAAGTTTTTATCGTACCTATGAGGGATTGAAACCCTCAACCACTTTAAGTGTCTTTTTGAGGTCGCCCCGTTTTTATCGTACCTATGAGGGATTGAAACCGGGTTTTGTTGGTTCCGGAAAGTCGTACAATGCTACACGTTTTTATCGTACCTATGAGGGATTGAAACAAATTTTTCAATATCCCCCTAATATAGCTCCATCTCCGGTTTTTATCGTACCTATGAGGGATTGAAACAAGATATTGCGATCAACGAGGCGGTCGAACTGGATAAGGTTTTTATCGTACCTATGAGGGATTGAAACACGGACGAGATGCCCGTAAACAAACCTGTTTTGGCTTTCAGTTTTTATCGTACCTATGAGGGATTGAAACTCTTGTCCGGCTTCGAAGCCGAAAACCAGCCAAGATTCGTTTTTATCGTACCTATGAGGGATTGAAACTCCTTTCAAATTTTGGTCAAAGACACAGACCAAATGTTTTTATCGTACCTATGAGGGATTGAAACGTGACAAACGGGCTTGCAAGTAAGAAACTAGCGATTGTTTTTATCGTACCTATGAGGGATTGAAACTCTCTAGAAATAGAGGTGAAGGAAATTGCAAAACGTGTTTTTATCGTACCTATGAGGGATTGAAACGCTCGAGATTTTCGATATGGTCAATCAAGTTCATGTTTTTATCGTACCTATGAGGGATTGAAACACCTTTAGCTCCTTCGCTGTGTCTCGGAAATTTGTCGTTTTTATCGTACCTATGAGGGATTGAAACCCGTTTGACCTTTATAATATTTTGGCTGTTATCAATGGTTTTTATCGTACCTACGAGGGATTGAAAC

>NC_016593|1|1|394989-398364|PILER-CR
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTGTTGCCCCTCCCCGAACACTTCCTCAACCTGCTCCAA
GTTTTTATCGTACCTATGAGGGATTGAAAC	CTCCGCGTAATTCGCTGTCTGTTTGCGTTTGCGCCGG
GTTTTTATCGTACCTATGAGGGATTGAAAC	AATCCTCCGTGATGTTTCCATAGCGAACGGTCTTGCT
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTTCATTCATCATTCTACGTACTTAGACGACGAAAAG
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACATGGGCAGTCGGCAACGCGGTGACACGAAAAGAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	CAACAAAGAGTCCGACGACGATACGCTTGAGATCATCGT
GTTTTTATCGTACCTATGAGGGATTGAAAC	CTTTTTGCAACGTCCGGGACCGCAAAAACGATAGGT
GTTTTTATCGTACCTATGAGGGATTGAAAC	GCAATACCTTTGAATCCAACCTTGCTGGATAAAG
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTTGGTCCATGATCGAAAAGATAATAAACGGCGCCGACT
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTCGTTGGATGACGTCGAGATTGTCACGGTTCCGTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	GGTTCTTGTGACAGAATGCCAACTTGTACAGCGGCATT
GTTTTTATCGTACCTATGAGGGATTGAAAC	GCAGCGCCGGTTGTCGAGGTGTACCTTGCGATTGA
GTTTTTATCGTACCTATGAGGGATTGAAAC	CGGCGACAACGGGAAACGAATCATTACGGACATAATCC
GTTTTTATCGTACCTATGAGGGATTGAAAC	CACTTGTAGAGCTAGAAGGTTCCCTTCGGAATACGATG
GTTTTTATCGTACCTATGAGGGATTGAAAC	GATTGGTGAACTCCGGTCTTACCGCGGTGATGCTCC
GTTTTTATCGTACCTATGAGGGATTGAAAC	GTTGGTATCTGCGAAGTGGTCGCGTATCCAACGTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	CCGTGGCAACCGTGGTACATGGAACTATTCGGAAATA
GTTTTTATCGTACCTATGAGGGATTGAAAC	AACTGGTGGCAGGAGCAAATATTTCTCTTACTCCAGAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGCACCAAAATAGACCTGGCGATGACGCTAAGGAA
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTGAATCCCGTTGATTATGTACAACGCCAAGTGCTGAAAA
GTTTTTATCGTACCTATGAGGGATTGAAAC	CAAGCATTGGAGGGAAAAGAATGATCTACATCTTGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCGCTGAAACAGCTGACTCGGTACAGTGAAGCCGA
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACACAACGGTACGGACATATCAGCTGACGCCGGAGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCCACGCTTGTAGTGAAAACAACAGCCGGAACTAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	GCCGAGGCCGAGGCGAAAGCGTTGGTGAAACTATTGCCCA
GTTTTTATCGTACCTATGAGGGATTGAAAC	GCATCTCGTTCCGGATGCGTGTCAGCACATTCAGCACAT
GTTTTTATCGTACCTATGAGGGATTGAAAC	AGGCTCGCTATGGCTACGACAACATCAGTGGAATAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTATATCATCATTTGGTGATTTGTAAACATCTTTTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	CAATCTCAAAAACTCGGTTGCGATCATCGAGCGAT
GTTTTTATCGTACCTATGAGGGATTGAAAC	CGTTTCCCAGCTCGAAAAAGTGGCGCAGAAGCAACAAA
GTTTTTATCGTACCTATGAGGGATTGAAAC	CTATTTCCCCAAGCGTGTGCTGGCACGCTGCAAGCATA
GTTTTTATCGTACCTATGAGGGATTGAAAC	CATTCGATATATGGACGACGTCATTGTACTGCACGAAA
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACCAAACAACTCAACCAATTTTTTAAAACTAATTCCC
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACCGTCTACCCATTCAACAAGAAAGGCTGTTTTTCT
GTTTTTATCGTACCTATGAGGGATTGAAAC	TAAGCGTCTGTCAATGTTTCTTGACGTTCGCTTTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCTATGAAACCCTTCGTACCGAAGAGAAACAGCGGTACTA
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGATCGCTCTGGCCGCAGTTAACTTATTAAATTTATCGA
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGAAAATCAGCAGATATTGCAAAAGCTCGAGGAA
GTTTTTATCGTACCTATGAGGGATTGAAAC	CCTCAACCACTTTAAGTGTCTTTTTGAGGTCGCCCC
GTTTTTATCGTACCTATGAGGGATTGAAAC	CGGGTTTTGTTGGTTCCGGAAAGTCGTACAATGCTACAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	AAATTTTTCAATATCCCCCTAATATAGCTCCATCTCCG
GTTTTTATCGTACCTATGAGGGATTGAAAC	AAGATATTGCGATCAACGAGGCGGTCGAACTGGATAAG
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACGGACGAGATGCCCGTAAACAAACCTGTTTTGGCTTTCA
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCTTGTCCGGCTTCGAAGCCGAAAACCAGCCAAGATTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCCTTTCAAATTTTGGTCAAAGACACAGACCAAAT
GTTTTTATCGTACCTATGAGGGATTGAAAC	GTGACAAACGGGCTTGCAAGTAAGAAACTAGCGATT
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCTCTAGAAATAGAGGTGAAGGAAATTGCAAAACGT
GTTTTTATCGTACCTATGAGGGATTGAAAC	GCTCGAGATTTTCGATATGGTCAATCAAGTTCAT
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACCTTTAGCTCCTTCGCTGTGTCTCGGAAATTTGTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	CCGTTTGACCTTTATAATATTTTGGCTGTTATCAATG
GTTTTTATCGTACCTACGAGGGATTGAAAC

>NC_016593|1|1|394989-398364|CRISPRCasFinder
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTGTTGCCCCTCCCCGAACACTTCCTCAACCTGCTCCAA
GTTTTTATCGTACCTATGAGGGATTGAAAC	CTCCGCGTAATTCGCTGTCTGTTTGCGTTTGCGCCGG
GTTTTTATCGTACCTATGAGGGATTGAAAC	AATCCTCCGTGATGTTTCCATAGCGAACGGTCTTGCT
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTTCATTCATCATTCTACGTACTTAGACGACGAAAAG
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACATGGGCAGTCGGCAACGCGGTGACACGAAAAGAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	CAACAAAGAGTCCGACGACGATACGCTTGAGATCATCGT
GTTTTTATCGTACCTATGAGGGATTGAAAC	CTTTTTGCAACGTCCGGGACCGCAAAAACGATAGGT
GTTTTTATCGTACCTATGAGGGATTGAAAC	GCAATACCTTTGAATCCAACCTTGCTGGATAAAG
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTTGGTCCATGATCGAAAAGATAATAAACGGCGCCGACT
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTCGTTGGATGACGTCGAGATTGTCACGGTTCCGTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	GGTTCTTGTGACAGAATGCCAACTTGTACAGCGGCATT
GTTTTTATCGTACCTATGAGGGATTGAAAC	GCAGCGCCGGTTGTCGAGGTGTACCTTGCGATTGA
GTTTTTATCGTACCTATGAGGGATTGAAAC	CGGCGACAACGGGAAACGAATCATTACGGACATAATCC
GTTTTTATCGTACCTATGAGGGATTGAAAC	CACTTGTAGAGCTAGAAGGTTCCCTTCGGAATACGATG
GTTTTTATCGTACCTATGAGGGATTGAAAC	GATTGGTGAACTCCGGTCTTACCGCGGTGATGCTCC
GTTTTTATCGTACCTATGAGGGATTGAAAC	GTTGGTATCTGCGAAGTGGTCGCGTATCCAACGTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	CCGTGGCAACCGTGGTACATGGAACTATTCGGAAATA
GTTTTTATCGTACCTATGAGGGATTGAAAC	AACTGGTGGCAGGAGCAAATATTTCTCTTACTCCAGAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGCACCAAAATAGACCTGGCGATGACGCTAAGGAA
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTGAATCCCGTTGATTATGTACAACGCCAAGTGCTGAAAA
GTTTTTATCGTACCTATGAGGGATTGAAAC	CAAGCATTGGAGGGAAAAGAATGATCTACATCTTGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCGCTGAAACAGCTGACTCGGTACAGTGAAGCCGA
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACACAACGGTACGGACATATCAGCTGACGCCGGAGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCCACGCTTGTAGTGAAAACAACAGCCGGAACTAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	GCCGAGGCCGAGGCGAAAGCGTTGGTGAAACTATTGCCCA
GTTTTTATCGTACCTATGAGGGATTGAAAC	GCATCTCGTTCCGGATGCGTGTCAGCACATTCAGCACAT
GTTTTTATCGTACCTATGAGGGATTGAAAC	AGGCTCGCTATGGCTACGACAACATCAGTGGAATAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTATATCATCATTTGGTGATTTGTAAACATCTTTTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	CAATCTCAAAAACTCGGTTGCGATCATCGAGCGAT
GTTTTTATCGTACCTATGAGGGATTGAAAC	CGTTTCCCAGCTCGAAAAAGTGGCGCAGAAGCAACAAA
GTTTTTATCGTACCTATGAGGGATTGAAAC	CTATTTCCCCAAGCGTGTGCTGGCACGCTGCAAGCATA
GTTTTTATCGTACCTATGAGGGATTGAAAC	CATTCGATATATGGACGACGTCATTGTACTGCACGAAA
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACCAAACAACTCAACCAATTTTTTAAAACTAATTCCC
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACCGTCTACCCATTCAACAAGAAAGGCTGTTTTTCT
GTTTTTATCGTACCTATGAGGGATTGAAAC	TAAGCGTCTGTCAATGTTTCTTGACGTTCGCTTTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCTATGAAACCCTTCGTACCGAAGAGAAACAGCGGTACTA
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGATCGCTCTGGCCGCAGTTAACTTATTAAATTTATCGA
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGAAAATCAGCAGATATTGCAAAAGCTCGAGGAA
GTTTTTATCGTACCTATGAGGGATTGAAAC	CCTCAACCACTTTAAGTGTCTTTTTGAGGTCGCCCC
GTTTTTATCGTACCTATGAGGGATTGAAAC	CGGGTTTTGTTGGTTCCGGAAAGTCGTACAATGCTACAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	AAATTTTTCAATATCCCCCTAATATAGCTCCATCTCCG
GTTTTTATCGTACCTATGAGGGATTGAAAC	AAGATATTGCGATCAACGAGGCGGTCGAACTGGATAAG
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACGGACGAGATGCCCGTAAACAAACCTGTTTTGGCTTTCA
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCTTGTCCGGCTTCGAAGCCGAAAACCAGCCAAGATTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCCTTTCAAATTTTGGTCAAAGACACAGACCAAAT
GTTTTTATCGTACCTATGAGGGATTGAAAC	GTGACAAACGGGCTTGCAAGTAAGAAACTAGCGATT
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCTCTAGAAATAGAGGTGAAGGAAATTGCAAAACGT
GTTTTTATCGTACCTATGAGGGATTGAAAC	GCTCGAGATTTTCGATATGGTCAATCAAGTTCAT
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACCTTTAGCTCCTTCGCTGTGTCTCGGAAATTTGTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	CCGTTTGACCTTTATAATATTTTGGCTGTTATCAATG
GTTTTTATCGTACCTACGAGGGATTGAAAC

>NC_016593|1|1|394989-398364|CRT
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTGTTGCCCCTCCCCGAACACTTCCTCAACCTGCTCCAA
GTTTTTATCGTACCTATGAGGGATTGAAAC	CTCCGCGTAATTCGCTGTCTGTTTGCGTTTGCGCCGG
GTTTTTATCGTACCTATGAGGGATTGAAAC	AATCCTCCGTGATGTTTCCATAGCGAACGGTCTTGCT
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTTCATTCATCATTCTACGTACTTAGACGACGAAAAG
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACATGGGCAGTCGGCAACGCGGTGACACGAAAAGAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	CAACAAAGAGTCCGACGACGATACGCTTGAGATCATCGT
GTTTTTATCGTACCTATGAGGGATTGAAAC	CTTTTTGCAACGTCCGGGACCGCAAAAACGATAGGT
GTTTTTATCGTACCTATGAGGGATTGAAAC	GCAATACCTTTGAATCCAACCTTGCTGGATAAAG
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTTGGTCCATGATCGAAAAGATAATAAACGGCGCCGACT
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTCGTTGGATGACGTCGAGATTGTCACGGTTCCGTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	GGTTCTTGTGACAGAATGCCAACTTGTACAGCGGCATT
GTTTTTATCGTACCTATGAGGGATTGAAAC	GCAGCGCCGGTTGTCGAGGTGTACCTTGCGATTGA
GTTTTTATCGTACCTATGAGGGATTGAAAC	CGGCGACAACGGGAAACGAATCATTACGGACATAATCC
GTTTTTATCGTACCTATGAGGGATTGAAAC	CACTTGTAGAGCTAGAAGGTTCCCTTCGGAATACGATG
GTTTTTATCGTACCTATGAGGGATTGAAAC	GATTGGTGAACTCCGGTCTTACCGCGGTGATGCTCC
GTTTTTATCGTACCTATGAGGGATTGAAAC	GTTGGTATCTGCGAAGTGGTCGCGTATCCAACGTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	CCGTGGCAACCGTGGTACATGGAACTATTCGGAAATA
GTTTTTATCGTACCTATGAGGGATTGAAAC	AACTGGTGGCAGGAGCAAATATTTCTCTTACTCCAGAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGCACCAAAATAGACCTGGCGATGACGCTAAGGAA
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTGAATCCCGTTGATTATGTACAACGCCAAGTGCTGAAAA
GTTTTTATCGTACCTATGAGGGATTGAAAC	CAAGCATTGGAGGGAAAAGAATGATCTACATCTTGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCGCTGAAACAGCTGACTCGGTACAGTGAAGCCGA
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACACAACGGTACGGACATATCAGCTGACGCCGGAGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCCACGCTTGTAGTGAAAACAACAGCCGGAACTAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	GCCGAGGCCGAGGCGAAAGCGTTGGTGAAACTATTGCCCA
GTTTTTATCGTACCTATGAGGGATTGAAAC	GCATCTCGTTCCGGATGCGTGTCAGCACATTCAGCACAT
GTTTTTATCGTACCTATGAGGGATTGAAAC	AGGCTCGCTATGGCTACGACAACATCAGTGGAATAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTATATCATCATTTGGTGATTTGTAAACATCTTTTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	CAATCTCAAAAACTCGGTTGCGATCATCGAGCGAT
GTTTTTATCGTACCTATGAGGGATTGAAAC	CGTTTCCCAGCTCGAAAAAGTGGCGCAGAAGCAACAAA
GTTTTTATCGTACCTATGAGGGATTGAAAC	CTATTTCCCCAAGCGTGTGCTGGCACGCTGCAAGCATA
GTTTTTATCGTACCTATGAGGGATTGAAAC	CATTCGATATATGGACGACGTCATTGTACTGCACGAAA
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACCAAACAACTCAACCAATTTTTTAAAACTAATTCCC
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACCGTCTACCCATTCAACAAGAAAGGCTGTTTTTCT
GTTTTTATCGTACCTATGAGGGATTGAAAC	TAAGCGTCTGTCAATGTTTCTTGACGTTCGCTTTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCTATGAAACCCTTCGTACCGAAGAGAAACAGCGGTACTA
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGATCGCTCTGGCCGCAGTTAACTTATTAAATTTATCGA
GTTTTTATCGTACCTATGAGGGATTGAAAC	TGAAAATCAGCAGATATTGCAAAAGCTCGAGGAA
GTTTTTATCGTACCTATGAGGGATTGAAAC	CCTCAACCACTTTAAGTGTCTTTTTGAGGTCGCCCC
GTTTTTATCGTACCTATGAGGGATTGAAAC	CGGGTTTTGTTGGTTCCGGAAAGTCGTACAATGCTACAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	AAATTTTTCAATATCCCCCTAATATAGCTCCATCTCCG
GTTTTTATCGTACCTATGAGGGATTGAAAC	AAGATATTGCGATCAACGAGGCGGTCGAACTGGATAAG
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACGGACGAGATGCCCGTAAACAAACCTGTTTTGGCTTTCA
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCTTGTCCGGCTTCGAAGCCGAAAACCAGCCAAGATTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCCTTTCAAATTTTGGTCAAAGACACAGACCAAAT
GTTTTTATCGTACCTATGAGGGATTGAAAC	GTGACAAACGGGCTTGCAAGTAAGAAACTAGCGATT
GTTTTTATCGTACCTATGAGGGATTGAAAC	TCTCTAGAAATAGAGGTGAAGGAAATTGCAAAACGT
GTTTTTATCGTACCTATGAGGGATTGAAAC	GCTCGAGATTTTCGATATGGTCAATCAAGTTCAT
GTTTTTATCGTACCTATGAGGGATTGAAAC	ACCTTTAGCTCCTTCGCTGTGTCTCGGAAATTTGTC
GTTTTTATCGTACCTATGAGGGATTGAAAC	CCGTTTGACCTTTATAATATTTTGGCTGTTATCAATG
GTTTTTATCGTACCTACGAGGGATTGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_016593.1\|WP_014194816.1\|403683_405993_-\|YhgE/Pip-domain-containing-protein	unknown	unknown	gnl\|CDD\|224428
NC_016593.1\|WP_014194822.1\|409299_409485_+\|hypothetical-protein	unknown	unknown	unknown
NC_016593.1\|WP_014194806.1\|393860_394787_+\|transposase	unknown	unknown	gnl\|CDD\|273806
NC_016593.1\|WP_011229827.1\|398439_398664_-\|hypothetical-protein	unknown	unknown	unknown
NC_016593.1\|WP_014194801.1\|384938_385586_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274008
NC_016593.1\|WP_014194799.1\|381668_382571_-\|proline/glycine-betaine-ABC-type-transport-system,-permease-component-fused-to-periplasmic-component	unknown	unknown	gnl\|CDD\|270246
NC_016593.1\|WP_011229819.1\|380524_381652_-\|betaine/proline/choline-family-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213262
NC_016593.1\|WP_014194819.1\|406645_408019_-\|GHKL-domain-containing-protein	unknown	unknown	gnl\|CDD\|380161
NC_016593.1\|WP_014194821.1\|408850_409276_+\|PepSY-domain-containing-protein	unknown	unknown	gnl\|CDD\|377164
NC_016593.1\|WP_014194823.1\|409465_410671_+\|PDZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|273938
NC_016593.1\|WP_014194800.1\|383151_384810_+\|IS1634-family-transposase	unknown	unknown	gnl\|CDD\|379471
NC_016593.1\|WP_014194803.1\|387223_388420_+\|TIGR02678-family-protein	unknown	unknown	gnl\|CDD\|274254
NC_016593.1\|WP_014194813.1\|402250_402775_-\|hypothetical-protein	unknown	unknown	unknown
NC_016593.1\|WP_011229818.1\|379640_380270_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224095
NC_016593.1\|WP_014194804.1\|388379_392501_+\|TIGR02680-family-protein	unknown	unknown	gnl\|CDD\|274256
NC_016593.1\|WP_015373859.1\|408008_408671_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_016593.1\|WP_014194812.1\|401637_402291_-\|PspA/IM30-family-protein	unknown	unknown	gnl\|CDD\|224755
NC_016593.1\|WP_014194805.1\|392497_393718_+\|TIGR02679-family-protein	unknown	unknown	gnl\|CDD\|274255
NC_016593.1\|WP_014194810.1\|400205_401438_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340949
NC_016593.1\|WP_014194802.1\|385730_387221_+\|TIGR02677-family-protein	unknown	unknown	gnl\|CDD\|131724

Protein	Function_ID	Function_description	E-value
NC_016593.1\|WP_014194806.1\|393860_394787_+\|transposase	gnl\|CDD\|273806	TIGR01784, Uncharacterized_protein_pSLT051, conserved hypothetical protein (putative transposase or invertase). Several lines of evidence suggest that members of this family (loaded as a fragment mode model to find part-length matches) are associated with transposition, inversion, or recombination. Members are found in small numbers of genomes, but in large copy numbers in many of those species, including over 30 full length and fragmentary members in Treponema denticola. The strongest similarities are usually within rather than between species. PSI-BLAST shows similarity to proteins designated as possible transposases, DNA invertases (resolvases), and recombinases. In the oral pathogenic spirochete Treponema denticola, full-length members are often found near transporters or other membrane proteins. This family includes members of the putative transposase family pfam04754.	5.17703e-15
NC_016593.1\|WP_014194801.1\|384938_385586_-\|hypothetical-protein	gnl\|CDD\|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	1.1407e-09
NC_016593.1\|WP_014194799.1\|381668_382571_-\|proline/glycine-betaine-ABC-type-transport-system,-permease-component-fused-to-periplasmic-component	gnl\|CDD\|270246	cd13528, PBP2_osmoprotectants, Substrate-binding domain of osmoregulatory ABC-type transporters; the type 2 periplasmic-binding protein fold. This family represents the periplasmic substrate-binding component of ABC transport systems that are involved in uptake of osmoprotectants (also termed compatible solutes) such as betaine, choline, proline betaine, carnitine, and L-proline. To counteract the efflux of water, bacteria and archaea accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	7.69592e-143
NC_016593.1\|WP_011229819.1\|380524_381652_-\|betaine/proline/choline-family-ABC-transporter-ATP-binding-protein	gnl\|CDD\|213262	cd03295, ABC_OpuCA_Osmoprotection, ATP-binding cassette domain of the osmoprotectant transporter. OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition, to the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	2.63752e-163
NC_016593.1\|WP_014194819.1\|406645_408019_-\|GHKL-domain-containing-protein	gnl\|CDD\|380161	NF033092, HK_WalK, cell wall metabolism sensor histidine kinase WalK. This model describes WalK as found in Staphylococcus aureus (sp\|Q2G2U4.1\|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.	3.5328e-75
NC_016593.1\|WP_014194821.1\|408850_409276_+\|PepSY-domain-containing-protein	gnl\|CDD\|377164	pfam03929, PepSY_TM, PepSY-associated TM region. The PepSY_TM family is so named because it is an alignment of up to five transmembranes helices found in bacterial species some of which carry a nested PepSY domain, pfam03413.	9.59383e-08
NC_016593.1\|WP_014194823.1\|409465_410671_+\|PDZ-domain-containing-protein	gnl\|CDD\|273938	TIGR02037, Probable_periplasmic_serine_protease_do/HhoA-like, periplasmic serine protease, Do/DeqQ family. This family consists of a set proteins various designated DegP, heat shock protein HtrA, and protease DO. The ortholog in Pseudomonas aeruginosa is designated MucD and is found in an operon that controls mucoid phenotype. This family also includes the DegQ (HhoA) paralog in E. coli which can rescue a DegP mutant, but not the smaller DegS paralog, which cannot. Members of this family are located in the periplasm and have separable functions as both protease and chaperone. Members have a trypsin domain and two copies of a PDZ domain. This protein protects bacteria from thermal and other stresses and may be important for the survival of bacterial pathogens.// The chaperone function is dominant at low temperatures, whereas the proteolytic activity is turned on at elevated temperatures. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides].	9.74542e-98
NC_016593.1\|WP_014194800.1\|383151_384810_+\|IS1634-family-transposase	gnl\|CDD\|379471	pfam14104, DUF4277, Domain of unknown function (DUF4277). This presumed domain is functionally uncharacterized. This domain family is found in bacteria and archaea, and is approximately 110 amino acids in length. There is a conserved NGLGF sequence motif.	5.78531e-33
NC_016593.1\|WP_014194803.1\|387223_388420_+\|TIGR02678-family-protein	gnl\|CDD\|274254	TIGR02678, hypothetical_protein, TIGR02678 family protein. Members of this protein belong to a conserved gene four-gene neighborhood found sporadically in a phylogenetically broad range of bacteria: Nocardia farcinica, Symbiobacterium thermophilum, and Streptomyces avermitilis (Actinobacteria), Geobacillus kaustophilus (Firmicutes), Azoarcus sp. EbN1 and Ralstonia solanacearum (Betaproteobacteria). [Hypothetical proteins, Conserved].	2.07075e-160
NC_016593.1\|WP_014194816.1\|403683_405993_-\|YhgE/Pip-domain-containing-protein	gnl\|CDD\|224428	COG1511, COG1511, Predicted membrane protein [Function unknown].	5.02067e-156
NC_016593.1\|WP_011229818.1\|379640_380270_-\|ABC-transporter-permease	gnl\|CDD\|224095	COG1174, OpuBB, ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism].	2.60548e-80
NC_016593.1\|WP_014194804.1\|388379_392501_+\|TIGR02680-family-protein	gnl\|CDD\|274256	TIGR02680, conserved_hypothetical_protein, TIGR02680 family protein. Members of this protein family belong to a conserved gene four-gene neighborhood found sporadically in a phylogenetically broad range of bacteria: Nocardia farcinica, Symbiobacterium thermophilum, and Streptomyces avermitilis (Actinobacteria), Geobacillus kaustophilus (Firmicutes), Azoarcus sp. EbN1 and Ralstonia solanacearum (Betaproteobacteria). Proteins in this family average over 1400 amino acids in length. [Hypothetical proteins, Conserved].	0
NC_016593.1\|WP_015373859.1\|408008_408671_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	8.88027e-79
NC_016593.1\|WP_014194812.1\|401637_402291_-\|PspA/IM30-family-protein	gnl\|CDD\|224755	COG1842, PspA, Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms].	7.55941e-21
NC_016593.1\|WP_014194805.1\|392497_393718_+\|TIGR02679-family-protein	gnl\|CDD\|274255	TIGR02679, conserved_hypothetical_protein, TIGR02679 family protein. Members of this protein belong to a conserved gene four-gene neighborhood found sporadically in a phylogenetically broad range of bacteria: Nocardia farcinica, Symbiobacterium thermophilum, and Streptomyces avermitilis (Actinobacteria), Geobacillus kaustophilus (Firmicutes), Azoarcus sp. EbN1 and Ralstonia solanacearum (Betaproteobacteria). [Hypothetical proteins, Conserved].	1.65742e-133
NC_016593.1\|WP_014194810.1\|400205_401438_-\|MFS-transporter	gnl\|CDD\|340949	cd17391, MFS_MdtG_MDR_like, Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	9.88376e-115
NC_016593.1\|WP_014194802.1\|385730_387221_+\|TIGR02677-family-protein	gnl\|CDD\|131724	TIGR02677, conserved_hypothetical_protein, TIGR02677 family protein. Members of this protein belong to a conserved gene four-gene neighborhood found sporadically in a phylogenetically broad range of bacteria: Nocardia farcinica, Symbiobacterium thermophilum, and Streptomyces avermitilis (Actinobacteria), Geobacillus kaustophilus (Firmicutes), Azoarcus sp. EbN1 and Ralstonia solanacearum (Betaproteobacteria). [Hypothetical proteins, Conserved].	0

>NC_016593.1|WP_014194806.1|393860_394787_+|transposase
MAKQRIDHDRLFKELLSTFFEEFLLLFFPNVYEHIDVRHLSFLTEELFTDVTAGEKHRVDLLVETKMKGEDGLVIVHVEHQSYAQRTFPERMFLYFSRLFQKYRRRIVPIAIFSYDEHHDEPSSLVVQFPFLTVLDFRYLTVELRKLPWRAYIRHDNPVAAALLSKMGYNEEEKVDVKKEFLRMLVRLELDEAKQRLLFGFFETYLRRSEEEEAKRRNEVSQMETKEAKRVMELIVSYEQRGLEKGIQQGIEQGIKQGMKQGMKQGRQEGIEEGKLDVVKRMLAKGYDVDTIHELTGLPVEKIERVKG
>NC_016593.1|WP_014194805.1|392497_393718_+|TIGR02679-family-protein
MSTAKEAAAFFRSEPGFRRLFIEMKHKYESLGRVGGAVSLEAFTDEEREAVAAFFGKDVSRVSLIAFEKQLGQTRFAGVGLVELLEQYFGAPLVSNKERRQAEEEERDRFFARLTEEHHWVESVRPQRFVQTAYETDRRSLEEAIRLVSAALGRLPLPSYMRLPLFAQQVAGDPHAFDLSTLPGRLLLSALQATVPGDWDMASVESVNELLQSVGLLREDILNFVTCANILAETKDGPHPVFSAAWEANTALNMPLRDVLSLVRARPAHGGTVYIVENAGVFSTLLDTRAPLVSTNGQMNLATMKLLDLLASSGAKLYYSGDFDPEGLAMAERLLERYGQAVTLWRFSLDDYAAANPVVELTPERLAKLASVTSEPLRPVKEAIGRKKKAGYQEAIIGRLTGDING
>NC_016593.1|WP_014194804.1|388379_392501_+|TIGR02680-family-protein
MANPWVLHRAGLINFWYYDEQYFHFADGKLLLRGSNGAGKSVTMQSLIPVLLDGKKTPDRLDPFGSRARRMEDYLLGEKDVVNRDERTGYLFLEYKRKESDQYVTTGIGLRAKRQKSLDFWGFVLFDNRRIGYDLQLYKQEKTGEKIPLTKRELATALGAGGTVVETQKDYMELVNKHVFRFESLEAFQELIELLIQLRSPKLSKDFKPTVIYEILESSLPPLTDDELRHLSDTIENMDQAKQQLEQLERDERALKRLCDQYRLYNEYMIAEKATEYVKAVKQAEQLAAAQHRLHDEEEQARKTLDELDESITRLRREEDVLRSREIDLAGHEVFQQAEKYEQLKSERERLQERWERHEQTIAEKERLERQHRRRLDESEARLDDLERKLEDELAQLRADAEEGAFSLHETNEDDFHRHRQKQQEFSFAAWKQEADRHIEQLEELARLWRRHDDVKRRYEEASTEAGERRREMDEWRHQQQKWEELLEQEKERFEQAVLAWVEQGGIDVSEADIQAFLRQMGALYELYSLDDLKRPFVQAYYDAVGKKKDEKWRLEHDIRLLEEKRAEREAELRQWREQRDPEPERDEQTTAARLALEREGIPFVPFYAAVEFVDDVPDDVRERIESALSHAGLLDALIAARDVDVDCDRVLIPKPVHMVHTLADYLRPDADAPVSAERIDEVLRSIVITDAEQEGGMTIDETGRYSLGLVRGHAPRRARAMFIGRAARERWRLENIAALEAEIAAVGQEIDRLRREHQAVGAAIQALADWLASFPADRDVRTAFEEGQEARRQAESKEREWKRQEEKAALLAREWKQIKQQLRDESAELDLAFTLDGCEQAQLAMKSYVRHLHELEVLYRETRHTEAMIAQQRERLAALETEIDEAKGERNRIRDEKERISLEIVEMERTLAQMGADDIRAEIARIQERLASLRREIPRLVNERARTEQQLMRLAEEREKEARREAFARELAAMWEKSFAREAALGLVDLDRSRSLLEQAKEAKQRYEAVLKETRSSLLARLNTVFFQESSNLTEYRASFEPLEEQTKPEWTAAAPDDEMAMKAADWREKQERHVIYLDYKGERATPFAVLAEVERDIVLQHEYMKEQDRELYEDVILKSVGRILRSRIQRAERWVNDMNKLMGGLDTSSGLVLSIQWKPKTAETEAELDTKELVRLLRLDPRLLREEDLQRVTNHFRSKIARARELLEERGQGSTLHQIIKEVLDYRKWFSFTLYYEKTNEPKRELTNHRFYQFSGGEKAMAMYIPLFAAAYSRYQEAGDDAPYIISLDEAFAGVDENNIRNLFGLVEQLGFNYIMNSQALWGDYDTVPALSICELVRPRNASFVTVIHYRWNGRVKQLMVNDKEWETIET
>NC_016593.1|WP_014194803.1|387223_388420_+|TIGR02678-family-protein
METAFDDKAKEALAALFEQFWIIRDKEPDLYQLVREREHVLKKYVEEKFGYRLIVHRYFAKLEKIPAEPEPWMGIESFQEPLDYALFCCLMAYLEGKAVEEKFLLSDVCEEIRAMYPGDLPVDWTNYSHRRALIRVLKTAEQIGLVRRMDGEIEAFAQHVEEEALYEVPVLARYFMRTYPKDLLQYESIDELLAEEWKASPQDYRRHRLYRKLFLSPAVHRTEGDEQDFYYLRNFRHRLRDDIEAHTPFRYELYKNAAMLTLPERQAPYTVFPDQKGTSEVILHFAALVRERLGEYPPDEYGRIRLTPEQFSAWLADCRRRYGAGWGKTYRDMSAAELVREVLSALNEWRMADVEHDTGMIVLYPLLGRMSGRYPDDFDAKEGGEHGESMGASSCGAD
>NC_016593.1|WP_014194802.1|385730_387221_+|TIGR02677-family-protein
MDATWLKPIVETKYLSTENAHRYRAILRYFYIQHERMRQYLFPEEVYAFLKQHEEFADYTEEELQQDLDQLVKWNNLIARQETSHVRTIEEFKKKRFRYQCSPYTVEIERMIRTLEQLGDSFGGSLERTRFDRLYASLSRMETIIASDFQEQPDEMHQVWEETFDYFKKIIQNSADYIAYLHGENLEERMTSESFLVYKEQFTAYLRDFIVALQKTSMQIEQLLEDLPEDGVRQFIEHVVDYERSIPRFADALPPRAVQIEEKWETWRSLCEWFLGRDGRESELSFLQYQTNEAIRRLTRVVQRLGERHHHFRSRKGDYLHLARWFSRLESIEEAHCLSAVVFGCFHTKHLVADFGATDNIYRDVWDEPPAEWVTKPRVRHYGEKKKPQAIEDKEREKEEARLRYLEEKAREEAELKQFVTDGKIVLADLPEVTPYVRKTLLGWIAKAMGREGQAMKTENGWVVNVVNKEGTICLRAEDGELVMPNYEIHVLSRGE
>NC_016593.1|WP_014194801.1|384938_385586_-|hypothetical-protein
MEALLREILHEVKATRTAVESLEQRVGALEGQVANLNERTGALEVLAANLNERTGALEAQMAQLNERTSALEQQFTQLNERTSNLEHQVAQLSERMGTVEHQVAQLNERMGTVEHQVAQLNEQTNTLARRIDLLDERTNETKAIVEALRHGQEVLTAKYEAMAHDLHHMKGDLTRITSILEDKVLPALAEHEAGLSVLNARVFKTESALHRLVYA
>NC_016593.1|WP_014194800.1|383151_384810_+|IS1634-family-transposase
MNVQVKKVYRNYYLNIISALFKKLGLPQLIDHLVPVDPQCQTRVSDAVQAIIYNMFDGRQALVHVERWAQEIDLEKLIRPGLHPSWLNDDALARHLDRLYEADIHKVISTCLIHIYRKEGLSLRAFHADTTDKTVYGAYESASLEALQITHGYNRHHRWQKQIGFGLVGNEDGIPFYGDVHDGNLPDKTWNPEVLSRVHEQLKQAKIEDEWIYVADSAAMTKDTLAQTKAVNAFLITRGPSSLRIVKRAFAEADSAHIPWSDPFTLAERNGATYRVWETSSTYEGHPVRLIVVESSALDQRKGKTLEKERTKEAELLREEQAHWERHPFSCREDAEQALASLKTSLRPRFHQVKAAVEEIVRPKKRRGRPKKGAEPEMETRYLLRLDVEFDPNAWEQARRKASRFVLVTTVPEEWKGQQMDAQEILKLYKGQISVEMNFAFLKDPFFTDEIYVKKPERVAVLGYLFLLALAIYRVFQRRVRQFITPEHPLKGAGGRKLTRPTGQAIFQLFQYVNVVLLELPDGRIQRSLDRSLTPEQRRILQGLGLDESIYV
>NC_016593.1|WP_014194799.1|381668_382571_-|proline/glycine-betaine-ABC-type-transport-system,-permease-component-fused-to-periplasmic-component
MLRKWMMTLLAVGLVFGLAACSGTSDAKGKIVISGKKFTEQVILTHLLAEYVKANTDLDVEVKDSLGGAFMLQQAIENGDVDMYVEYTGTGYLNILKQPYDPKKTPEQIYNETKKLYKEKYNIAWLKPLGFNNTYALAMRRDLAEKLGVKTYSDLAKHSSSLTFGSDAEFFERSDGYDGLVDTYGFQFKKKVTIDPDLQYEAAKNGEIDVITAYTTDARIKKYDLVVLKDDKQYFPPYHAVPIIRQEVLDANPDLEEKLNKLANILTDEKMMELNGEVNLEGKRPREVAIDFLKAEGLID
>NC_016593.1|WP_011229819.1|380524_381652_-|betaine/proline/choline-family-ABC-transporter-ATP-binding-protein
MIRFENVTKQYEDGFVALKNINLEIRKGELVALIGPSGCGKTTTMRMINRLIEPTSGKVYIDGQDISQLDPVELRRNIGYVIQQIGLFPHMTIAENIALVPKLKKWEKHAYEKRVDELLELVGLDPATFKHRYPSELSGGQQQRVGVVRALAAEPDIILMDEPFSALDPISREQLQDDIVRLQEEIHKTIVFVTHDMDEAIKIADRIALMKDGEIVQFATPDQMLRRPANSFVREFIGEDRLRIRHTAVPTAEDLMSADVATISPRRGLAEAFRLMKAKKVDSLVVVDKKQVFLGIVTLKQIEQRYQEEHLLVADIADYDVTTLSKEADVTNVAALFQDPDVRIIPVLDGDRLVGGITRSSMMRALAEWTFQQHA
>NC_016593.1|WP_011229818.1|379640_380270_-|ABC-transporter-permease
MELLQTFIERKNDIWIAFQEHVLLSAIAMSIAIVIAVPLGVVLTRYRKLAEPIIGIAAIIQTIPSLALLGFMLPIFGIGKLPAIIALTLYALLPILRNTYTGILGVDPTLVDAGRGMGMTSRQILWMVELPLSLPVIMAGVRTATVLTIGVAALATFIGAGGLGDLIDRGLRIADKNLILAGAIPAAMLAIVFDWLLRKVEKKVTPKGL
>NC_016593.1|WP_011229827.1|398439_398664_-|hypothetical-protein
MQQRQRKAVNNHAWWINGAIQKKQMPKRSPCAKQKSGFLQSKRRKNEQPKQNEAVDRGSAAIRFLQTEDVHTMA
>NC_016593.1|WP_014194810.1|400205_401438_-|MFS-transporter
MNWKRSVRVLWLCNFMVSAGMTMVIPFLSLFLWQMGVTEHHALSIWTGLVFSVTFLSAAVMAPIWGVFADKYGQRANLIRAGIGMGLITGCMAFAASPMALLALRFLVGFFSGFITVSFSYLARVVPRDHSGEALGTLQTGSIAGNIIGPLIGGALSDLFGFRPVFLVTGLCILLTLLPVIFWLEKDPVVPQTKENKASFKEVFRHRPLIVLFIATFLVQIAVLGVNSMMTIFVQSLIGHSSNLAFLSGLASSITGIATIIGAPYLGKLGDRIGQEKTLPILLVLSGLFALPQVWTDNIYELYVWRFLQGLVVGGVWPSIQALINAQSPRRIQGRVFGVTASSRFLGNLTGPTAAGAIAGFFSISSIFVLSGLLLIATGALVGYATHDRAWREEMKEKIAAWTHRLHSRY
>NC_016593.1|WP_014194812.1|401637_402291_-|PspA/IM30-family-protein
MGIFRRIKTIILAEANEQIDRWEDPVAMTKQYLRQLEQQLEQGRQALAQQWVAERRYETLIAQAEATIEKRSRQAKLALERNEESVAKLALRDKLLYEKKLEAYKQQYDAIKAKTVEVANRLNQLRERYDGLAAKQLELAARVNAAQALKQIDTALASFSADEALRGFARMEERVIALEAEAAAARFGTNAALSPVPFDEEVERELAKWKEAQANNA
>NC_016593.1|WP_014194813.1|402250_402775_-|hypothetical-protein
MKKAQTFLFIALAALVGWSAFHVLTPHEVMAHGRPGVPFAGVHDGFGHHHREFGMGSREGWMMAGLFMWWLIPFLLVGAGAIWLAAARSKRWIGWALVALGVAAILPKWVLILLALAAVYTLGRRQARKTAIAEAWAPALPSVPVDWLDEWEKTIQKEAKQHGHFSPDQNDYSR
>NC_016593.1|WP_014194816.1|403683_405993_-|YhgE/Pip-domain-containing-protein
MRAFQLWMQEWKAVASNRKTLIPIIAVLFIPLLYSGMFLWAFWDPYDHLDELPVAVVNKDKGTTFEGKAFHLGDDLVEKLKEKKQFNWHFVNEHEGEKGLKEQKYYMLIQIPEDFSQNATTLQDDHPKKLQLIYKPNEGFNFLSAQIGGTAVEKIKTEVAKTLTETYAENMFENIQTLADGLTKASDGAKQLHDGLGEAKNGTNKLYDGMKKAEDGSKDLHHHLATLAEKSMAFTDGLNQAVNGSTQVQAGVQMLDNGMKHMADGQGQLLDGAKQAQEGTANLASGAKRVYEGMQTLDARMPQLLQGSEQLSGGAEKLASSLAQWQQGAARVQTGATQVTGGLEQLAAQLDALIAQTPDPTQKAVYERLKENVEKLSFGSKQVENGIAQLNDGAKALQSGAASLNSGAKQLHEGHIALDRGVDELLSGQQQLVNGANALLNGQEKLVAGMNTLHEKMKEAEQGADKLAKGGQTLTSGLQVLAQGADRLQDGAHQLADGSQQLASGMNELTSGTRHLQDGMNRLTDGSEELADQLKEGAKKASDVKANKDVYDMFAEPVKVKNEKVNEVPNYGTGFTPYFLSLGLFVGALLLSIVFPLREPAAVPRSPFHWFFAKFGVLIGVGIFQALLADSVLLYGLDLQVKSVPFFILFSVVTSIAFLSVIQFLVTTFGDPGRFIGIVVLILQLTTSAGTFPLELIPRSLQHFNAWLPMTYSVFGFKAVISSGDFSFMWENIGKLLLFIVAMMVGTMAYFTMQHRRRFATAVEQASEA
>NC_016593.1|WP_014194819.1|406645_408019_-|GHKL-domain-containing-protein
MKNNWREWRDWLRRLGSADLFRRAHWRLTALYSGIFTLFLALFVMIAAALFYWIATSDQERRISRLAEQEANTIEQVLLKQSNFDLFDDENVILLSEDQLFFYVIGPDGGLLAGDEVHPRLRPYFLNALSHLKANERAPVYMSVSLPEHMPGLAREAARDWRVLAAARPLVIHGDFVGMLYIGMDVTSFFGVFHWLLIVLIGLAVLFLAVGVALSFFMSKRALAPIEEAYERQRQFVADASHELRTPLSVVFSSVEALSLEEDVMKNDFARRLLDRLRDELKRITKLMNDLLTLARADAKHAALELSKQTFDFRPHAERTFQLMSELAAKKQITMHFHAPEQALVTADPDKLTQLLYILLDNAIKYTPEGGEVTLSIRTEPKHVFLSVKDTGIGIPPEDIGRIFDRFYRVDKARSRQQGGHGLGLSIAKWIVEAHGGTIHVQSQLGQGSEFLVRLPA
>NC_016593.1|WP_015373859.1|408008_408671_-|response-regulator-transcription-factor
MKILLAEDDLHLGELIVHLLKKKGIDHIDWVQEGEDAYDYAMAEFYDVVVLDWMLPNGDGVDICRRLRQNGYTGAILMLTAKDAVHDRVTGLEAGADDYLVKPFEIDELVARLKALARRTFVPLQEEKVAFHGFTLNRTSHTLHRGDEEIFLTPREFQLLDLLVQNQGQVVPRETILDRVWGWDADVSMKTIDATIKLLRKKLKDDVIQTVRGVGYKIEK
>NC_016593.1|WP_014194821.1|408850_409276_+|PepSY-domain-containing-protein
MRKMRNLHLWIGLISSIFLLVEAVTGLLLSEPWLIGQAERGEMHRAAQERMNAFGAGQTSGAGASTAPMAPRAEGGGSSLMMFVRQLHEGRIGSLDIRWAVDVAAVAMIILTATGIFLSIRTLAAGRRRKQKRMTPAPETT
>NC_016593.1|WP_014194822.1|409299_409485_+|hypothetical-protein
MHQNNRKKQRRWSSLYARPIDVGGIVVFRPPFHCLAAIRTKMSYMRLGITKEEMSHGHDAI
>NC_016593.1|WP_014194823.1|409465_410671_+|PDZ-domain-containing-protein
MDMMPFEPTPTPEPKRRGRFVSWLAASVAGAVIGSAATWYVAPKWMHEETNSQTETAETTAKSEALPLQPTANVNTNMIAAINKVADAVVGVVNIQKQVDFFSDQAQDTEAGTGSGVIFKKEGDAAYIVTNNHVIEGANKVEVALANGKKVKAEIVGADALTDLVVLKIPAEGVTKVASFGDSSKVKIGEPVAAIGNPLGLDLSRTVTEGIVSGKRTMPVSTSAGDWEIDVIQTDAAINPGNSGGALINSAGQVIGINSMKIAETGVEGLGFAIPSENVKPIVEQLMKDGKIKRPYLGVQLVDVADLSDDVRTNELKLPSNITSGAAVTSVEPFSPAAEAGLKSKDVITAINGEKIDSVSALRKYLYTKTAVGDRIKLTIYRDGFETTVSVTLKARDSSQS

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Crispr_ID: NC_016593_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016593_2

1129828-1129921

Orphan

Consensus_repeat	Method
GTAGACACAAAATATAGTGCGGAAGAATCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_016593_2

>merge|NC_016593|2|1129828-1129921|CRISPRCasFinder
GTAGACACAAAATATAGTGCGGAAGAATCGATTGCGGAAATGAGAGTGAAAACAAGGAAAATTCGTAGACACAAAATATAGTGCGGAAGAATCG

>NC_016593|2|2|1129828-1129921|CRISPRCasFinder
GTAGACACAAAATATAGTGCGGAAGAATCG	ATTGCGGAAATGAGAGTGAAAACAAGGAAAATTC
GTAGACACAAAATATAGTGCGGAAGAATCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_016593.1\|WP_011230529.1\|1123763_1124546_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|181295
NC_016593.1\|WP_011230527.1\|1121492_1122359_+\|NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224995
NC_016593.1\|WP_014195329.1\|1128809_1129784_+\|NADPH:quinone-oxidoreductase-family-protein	unknown	unknown	gnl\|CDD\|176203
NC_016593.1\|WP_014195334.1\|1137921_1138356_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372949
NC_016593.1\|WP_011230532.1\|1126962_1128021_+\|phosphotransferase-family-protein	unknown	unknown	gnl\|CDD\|270703
NC_016593.1\|WP_014195325.1\|1124567_1126187_+\|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl\|CDD\|341259
NC_016593.1\|WP_011230544.1\|1139437_1140205_+\|2,4-dienoyl-CoA-reductase	unknown	unknown	gnl\|CDD\|181077
NC_016593.1\|WP_025039138.1\|1133713_1135342_+\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635
NC_016593.1\|WP_011230526.1\|1120680_1121466_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187602
NC_016593.1\|WP_014195324.1\|1120358_1120577_+\|hypothetical-protein	unknown	unknown	unknown
NC_016593.1\|WP_014195326.1\|1126280_1126865_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380061
NC_016593.1\|WP_011230538.1\|1132889_1133540_+\|DUF1906-domain-containing-protein	unknown	unknown	gnl\|CDD\|119380
NC_016593.1\|WP_014195328.1\|1128030_1128813_+\|2-phosphosulfolactate-phosphatase	unknown	unknown	gnl\|CDD\|377205
NC_016593.1\|WP_011230536.1\|1131397_1131625_-\|IDEAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|235145
NC_016593.1\|WP_011230528.1\|1122533_1123745_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173844
NC_016593.1\|WP_011230543.1\|1138424_1139294_-\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|277331
NC_016593.1\|WP_014195332.1\|1135338_1136364_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237512
NC_016593.1\|WP_033007559.1\|1136363_1137770_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133045
NC_016593.1\|WP_020278637.1\|1131814_1132813_+\|magnesium/cobalt-transporter-CorA	unknown	unknown	gnl\|CDD\|213365
NC_016593.1\|WP_014195330.1\|1130084_1131242_-\|aminotransferase-A	unknown	unknown	gnl\|CDD\|236075

Protein	Function_ID	Function_description	E-value
NC_016593.1\|WP_011230529.1\|1123763_1124546_+\|SDR-family-oxidoreductase	gnl\|CDD\|181295	PRK08213, PRK08213, gluconate 5-dehydrogenase; Provisional.	3.73524e-161
NC_016593.1\|WP_011230527.1\|1121492_1122359_+\|NAD(P)-dependent-oxidoreductase	gnl\|CDD\|224995	COG2084, MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism].	6.27398e-126
NC_016593.1\|WP_014195329.1\|1128809_1129784_+\|NADPH:quinone-oxidoreductase-family-protein	gnl\|CDD\|176203	cd08241, QOR1, Quinone oxidoreductase (QOR). QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR acts in the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site, and a structural zinc in a lobe of the catalytic domain. NAD(H)-binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	8.03154e-118
NC_016593.1\|WP_014195334.1\|1137921_1138356_-\|hypothetical-protein	gnl\|CDD\|372949	pfam14177, YkyB, YkyB-like protein. The YkyB-like protein family includes the B. subtilis YkyB protein, which is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 150 amino acids in length. There are two conserved sequence motifs: NRHAKTA and HLG.	5.68626e-75
NC_016593.1\|WP_011230532.1\|1126962_1128021_+\|phosphotransferase-family-protein	gnl\|CDD\|270703	cd05154, ACAD10_11_N-like, N-terminal domain of Acyl-CoA dehydrogenase (ACAD) 10 and 11, and similar proteins. This subfamily is composed of the N-terminal domains of vertebrate ACAD10 and ACAD11, and similar uncharacterized bacterial and eukaryotic proteins. ACADs are a family of flavoproteins that are involved in the beta-oxidation of fatty acyl-CoA derivatives. ACAD deficiency can cause metabolic disorders including muscle fatigue, hypoglycemia, and hepatic lipidosis. There are at least 11 distinct ACADs, some of which show distinct substrate specificities to either straight-chain or branched-chain fatty acids. ACAD10 is widely expressed in human tissues and highly expressed in liver, kidney, pancreas, and spleen. ACAD10 and ACAD11 are both significantly expressed in human brain tissues. They contain a long N-terminal domain with similarity to phosphotransferases with a Protein Kinase fold, which is absent in other ACADs. They may exhibit multiple functions in acyl-CoA oxidation pathways. ACAD11 utilizes substrates with carbon chain lengths of 20 to 26, with optimal activity towards C22CoA. ACAD10 may be associated with an increased risk in type II diabetes. The ACAD10/11-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).	3.18791e-86
NC_016593.1\|WP_014195325.1\|1124567_1126187_+\|long-chain-fatty-acid--CoA-ligase	gnl\|CDD\|341259	cd05936, FC-FACS_FadD_like, Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD. This subfamily of the AMP-forming adenylation family contains Escherichia coli FadD and similar prokaryotic fatty acid CoA synthetases. FadD was characterized as a long-chain fatty acid CoA synthetase. The gene fadD is regulated by the fatty acid regulatory protein FadR. Fatty acid CoA synthetase catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.	0
NC_016593.1\|WP_011230544.1\|1139437_1140205_+\|2,4-dienoyl-CoA-reductase	gnl\|CDD\|181077	PRK07677, PRK07677, short chain dehydrogenase; Provisional.	0
NC_016593.1\|WP_025039138.1\|1133713_1135342_+\|diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	1.32856e-53
NC_016593.1\|WP_011230526.1\|1120680_1121466_+\|SDR-family-oxidoreductase	gnl\|CDD\|187602	cd05344, BKR_like_SDR_like, putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR. This subgroup resembles the SDR family, but does not have a perfect match to the NAD-binding motif or the catalytic tetrad characteristic of the SDRs. It includes the SDRs, Q9HYA2 from Pseudomonas aeruginosa PAO1 and APE0912 from Aeropyrum pernix K1. BKR catalyzes the NADPH-dependent reduction of ACP in the first reductive step of de novo fatty acid synthesis (FAS). FAS consists of four elongation steps, which are repeated to extend the fatty acid chain through the addition of two-carbo units from malonyl acyl-carrier protein (ACP): condensation, reduction, dehydration, and a final reduction. Type II FAS, typical of plants and many bacteria, maintains these activities on discrete polypeptides, while type I FAS utilizes one or two multifunctional polypeptides. BKR resembles enoyl reductase, which catalyzes the second reduction step in FAS. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	1.80788e-105
NC_016593.1\|WP_011230538.1\|1132889_1133540_+\|DUF1906-domain-containing-protein	gnl\|CDD\|119380	cd06418, GH25_BacA-like, BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of Bacillus subtilis. BacA has a C-terminal catalytic glycosyl hydrolase family 25 (GH25) domain and an N-terminal peptidoglycan-binding domain comprised of three alpha helices which is similar to a domain found in matrixins.	6.50232e-46
NC_016593.1\|WP_014195326.1\|1126280_1126865_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|380061	pfam17932, TetR_C_24, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in family members such as HTH-type transcriptional repressor KstR2 as well as fatty acid metabolism regulator proteins. In Mycobacterium smegmatis, KstR2 is involved in involved in cholesterol catabolism, while YsiA in Bacillus subtilis is involved in fatty acid degradation.	4.14559e-37
NC_016593.1\|WP_014195328.1\|1128030_1128813_+\|2-phosphosulfolactate-phosphatase	gnl\|CDD\|377205	pfam04029, 2-ph_phosp, 2-phosphosulpholactate phosphatase. Thought to catalyze 2-phosphosulpholactate = sulpholactate + phosphate. Probable magnesium cofactor. Involved in the second step of coenzyme M biosynthesis. Inhibited by vanadate in Methanococcus jannaschii. Also known as the ComB family.	1.13745e-79
NC_016593.1\|WP_011230536.1\|1131397_1131625_-\|IDEAL-domain-containing-protein	gnl\|CDD\|235145	PRK03636, PRK03636, hypothetical protein; Provisional.	1.40991e-12
NC_016593.1\|WP_011230528.1\|1122533_1123745_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|173844	cd01155, ACAD_FadE2, Acyl-CoA dehydrogenases similar to fadE2. FadE2-like Acyl-CoA dehydrogenase (ACAD). Acyl-CoA dehydrogenases (ACAD) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACAD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. ACAD's are generally homotetramers and have an active site glutamate at a conserved position.	0
NC_016593.1\|WP_011230543.1\|1138424_1139294_-\|metallophosphoesterase	gnl\|CDD\|277331	cd07385, MPP_YkuE_C, Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain. YkuE is an uncharacterized Bacillus subtilis protein with a C-terminal metallophosphatase domain and an N-terminal twin-arginine (RR) motif. An RR-signal peptide derived from the Bacillus subtilis YkuE protein can direct Tat-dependent secretion of agarase in Streptomyces lividans. This is an indication that YkuE is transported by the Bacillus subtilis Tat (Twin-arginine translocation) pathway machinery. YkuE belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	2.3266e-69
NC_016593.1\|WP_014195332.1\|1135338_1136364_+\|hypothetical-protein	gnl\|CDD\|237512	PRK13800, PRK13800, fumarate reductase/succinate dehydrogenase flavoprotein subunit.	0.000745487
NC_016593.1\|WP_033007559.1\|1136363_1137770_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|133045	cd06423, CESA_like, CESA_like is the cellulose synthase superfamily. The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.	1.55363e-58
NC_016593.1\|WP_020278637.1\|1131814_1132813_+\|magnesium/cobalt-transporter-CorA	gnl\|CDD\|213365	cd12831, TmCorA-like_u2, Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family. This subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of the TmCorA-like family are found in all three kingdoms of life. It is a functionally diverse family which includes the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, and three Saccharomyces cerevisiae proteins: two located in the plasma membrane: the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.	1.9334e-178
NC_016593.1\|WP_014195330.1\|1130084_1131242_-\|aminotransferase-A	gnl\|CDD\|236075	PRK07683, PRK07683, aminotransferase A; Validated.	0

>NC_016593.1|WP_014195329.1|1128809_1129784_+|NADPH:quinone-oxidoreductase-family-protein
MKFVQFVEYGGPDVLRVCEGERPKPTGRQVVIEAEAIGVNYADTARREGRYVVPTPLPFIPGTEVAGVVREVGPEVQTVLPGQRVVALIESGGYAEFVAVDERAVVPLPDGMDARQAAALPVQGLSAYHILKTMGRLEEGETVLVHAAAGGVGTIAVQLAKRFGAKMVIATASTEEKRALAKQLGADVTIDYTKDSWAADVMEATGGRGVDVALEMAGGDVFHQTLDCLAPFGRLVVYGAASGEMTRLNPVRLMAKNWSVIGFFLPQIMKKRALYEQSLRELLAWVQEGSLKLMIGGVYPLEQASEVHRLLQGRKTHGKLLLVP
>NC_016593.1|WP_014195328.1|1128030_1128813_+|2-phosphosulfolactate-phosphatase
MTKVHVVLRKEDIDEMALADRKVAVVFDVLLATSSITAVLSAGARSVIPVRDAEEAKEIALRLPEGSYELVGEYEGRTIAGFHPPAPLFLQTVCPGKTVVLSTTNGTVAIRRAQPARAVYAASLLNSPAVSEHICRLHQEETIIVICSGSSGRFCLEDFYGAGYFVHCLIEQGINAAELSDSATAAWFFYRQYSDEGKAKEVLSASRVGRWMTAYGLEKEIDYINRHGSLSAVPKLELGPFGLELRNMASTKVTKEGISP
>NC_016593.1|WP_011230532.1|1126962_1128021_+|phosphotransferase-family-protein
MTAIIPVRKGEELPAGKLAKFLRTVLPDMPDGELEIQQFSAGRSNLTYLLRCGEWEAVLRRPPFGPVPPKAHDMKRESTWLSEIHPLFPLAPKPFYFCEDESVIGSPFFVMERRHGVVIDSDFPDGITPTEEVCRGISETMVETLVRIHQIDYTNTRLVQMVKPDGFMERQVHGWIQRYERAKTDDIPEAEALMKWLASHIPPQREATVIHYDFKLNNALFAKDDITKMVGLFDWEMSTVGDPLADLAVAMSYWIEEDDPPLIKSGFGRAPVTVRPGFYTREQFIEAYAKKSGRDVSDIHVYLTFAYFKLAVICQQIYYRYRRGQTNDERFRHFGQFVEALIEHAWQLATGR
>NC_016593.1|WP_014195326.1|1126280_1126865_+|TetR/AcrR-family-transcriptional-regulator
MKEKIMAASIELFEQNGFSETSIQDIVDALGVTKGTFYYYFTSKEELLMDIHLRYIEGLLDEEERIISDKRRPLREKLYDIIFMLIHNVERQGREARIFFREMKHLSEEHLQKVKEKRDLFRQRLQALIEEGMKNGELRCDLSPSIATLTVLGAANWSYQWFRPDGELTDAEVAKQMVEILLDGMSAPSVSKAE
>NC_016593.1|WP_014195325.1|1124567_1126187_+|long-chain-fatty-acid--CoA-ligase
MSEKRALSLYPEHISFYMDIPDKTVCDVLHERAAEFGSQPALTFYDKTITYAELEAAVNRFTSSLQALGVQKGDRVAIMLPNCPQYVIAYYGILQAGAIVTQVNPMLVERELAYLLKDSGAETIVIYEPLYPRLAAVRGETAVKQAITVSFGAPPSVSLAEGDVTFDEFLAAGSGAVRPVSIEPAHDVAVLQYTGGTTGRSKGAMLTHRNIFANVLQCAEFFKGTFEFGKERYLTVIPLFHVFAMTSGMNLAIYQGAENILLPRFELKEVLETIRDKQPTVFPGVPTMYVAITNTPGVEQYGISSIKTCNSGSAPMPLELMRDFEAKTGAVILEGYGLSEASPVTHCNPPFAARKPGTVGIGMPLTEYKVVDVATGTQELPPGEVGELIIRGPQVMKGYWNMPEETAAALRDGWLYTGDLASIDEEGYVTIVDRKKDLIIAGGYNIYPREIEEVLYEHPAVKEAAAVGVPDPYRGETVKAIIVLKDGMQASEEEILAHCRKNLAAYKVPRIVEFRAELPKTNVGKILRRALREEASRPQ
>NC_016593.1|WP_011230529.1|1123763_1124546_+|SDR-family-oxidoreductase
MHVLDLFKIEGKTAIVTGGGRGLGEQIAVGLAEAGANVVVCSRKVEACEQVKEKLEQLGVRSLALRCDVTNPEEVKHVVETTVKEFGGIDILVNNSGATWGAPVEEMPLEAWQKVINVNVTGTFLMSQAVGKVMIAKQTGGSIINIASVAGLGGTHPDILNTIGYNTSKGAVITFTRDLAAKWGKHGIRVNAVAPGFFPTKMSKVVLERVGKKVLEHTPLGRFGGEDDLKGAVLFLASPASAFVTGALLVVDGGSHATGI
>NC_016593.1|WP_011230528.1|1122533_1123745_+|acyl-CoA-dehydrogenase
MDFSYSPKVKELIKKLSAFMEDYIYPNERVYEEQLNTQESRWSGVPPIIEELKEKAKKEGLWNLFLPDSEYGAGLTNVEYAPLCEIMGRSLIAPEVFNCNAPDTGNMEVLVRYGTEEQKKKWLIPLLNGEIRSCFSMTEPDVASSDATNIRASIVRDGDEYVITGRKWWSSGAGDPRCKVAIVMGKTNPDAPKHEQQSMIIVPLDTPGVKIERMLPVFGFDHAPHGHAEITYDHVRVPKENIIWGEGKGFAIAQGRLGPGRIHHCMRLIGAAERALELMCRRVQSRVAFGKPLAEHGVIREWIAQSRIEIEQARLLTLKAAYMMDTVGNKAARKEIAMIKVVAPNVALKVIDRAIQAFGAAGVSNDFPLAAMWANSRTLRLADGPDEVHKEQVAKLELRQYQQ
>NC_016593.1|WP_011230527.1|1121492_1122359_+|NAD(P)-dependent-oxidoreductase
MKTIGFIGLGVMGKSMARHLLKAGYPLLAYTRTKEKAEDLLQEGAVWKETVADLAREADVVMTMVGDPRDVEQVYFGEGGILENARPGTYVIDMTTSTPTLAQSIYEAAKQKGIHALDAPVSGGDIGAREGTLTIMVGGDEDVFLACKPILERLGTNIVRQGGAGAGQHTKMCNQIAIATNMIGVCEAMAYAKRAGLDPFKVLESIAKGAAGSWSLSNLAPRMLSGDFAPGFYVKHFIKDMKIALEEAERMNLPLPGLALAKQLYEELAQAGEENSGTQALYKRYVKA
>NC_016593.1|WP_011230526.1|1120680_1121466_+|SDR-family-oxidoreductase
MELGLAGKTALVAASSQGLGKAIARALVLEGTNVMITSRNEEKLHEVAEELNSLHKGRVAYTRTDVTNADDIRQLVAKTVETFGTIDLLVNNAGGPPAGTFETVSDEDWQYAFELNLLSYIRLIREALPYLKKKGGKIVNIASSSIKEPIPGLILSNTFRTGIVGLTKTLAVELAPDGILINTVAPGRIATERVAFLDKVNAEKLGITKEEMEARMKSAIPLGRYGTPEEFANVVVFLLSEANSYVTGQALIVDGGMVKAI
>NC_016593.1|WP_014195324.1|1120358_1120577_+|hypothetical-protein
MPERGRNDHPHMFYRDGARESVINDPTADGAEAIGVRTDADPMKDANPNPFHVDRLNVEEGMKRFQSFFEER
>NC_016593.1|WP_014195330.1|1130084_1131242_-|aminotransferase-A
MRHLIQPRVQAIQLSGIRQFFNLVAGRPGLVSLTIGQPDFPTPDHVKAAAQEAIAADFTTYTANAGLLELRQAACQFVADKYGLRYTPDEVIATVGASQALDIAFRTILEEGTEVLLPAPVYPGYEPLIRLCGAKPVYIDTRPNGFRLSAELIAPYLTEKTRCLVLPYPSNPTGTALSAEELENIASLLKGRPIWIVSDEIYSELVYHGRHHSIAEWLPEQTIVINGLSKSHSMTGWRIGFVFAPAFAVEQMVKVHQYSVSCTSSISQKAAVEALTAGKHDAEAMRAAYAERLEYAYHRLTAMGLPVEKPDGAFYLFPSIAAFGMSSFDFALDVVENAGVALVPGSAFSEYGEGHVRLSYAYSLDVLKEGLDRLERYIQTKRRRP
>NC_016593.1|WP_011230536.1|1131397_1131625_-|IDEAL-domain-containing-protein
MYEKQYPNEGAVLFNQPEEKSSYGPMAEQVLKEAIFQFQRKKLMEQIDEALAAGNKPLFFKLSAQYNDLLKKYGA
>NC_016593.1|WP_020278637.1|1131814_1132813_+|magnesium/cobalt-transporter-CorA
MAMIRTCVVTKEFEILYDVDLTLVNSPDVSWYWVDFHEPTDEESALLASFFRFHPLAIEDCLEYVQRPKLDFYDRYLFVVLHAIAGMTLEAEEVDLFVGQNFIVSFHKSAIHAVDEVWERLKHEEDVQQGPFHVMYRLIDKLVDDYFPPLYHIEDVLNDLEENTNNEPIHDIIEKVFDIRGDLSKLRRTIVPMRDLLYRIIHSDRLQRMKERQLYFHDIYDHLLKLSEMIETNREITADIRDSYLSLNSNRMNNIMMTFTAITTIFMPLSFIAGIYGMNFDYMPELHWKYGYFVVLAAMAVIGMTMFVWFKRNGWFQLLKGDWAKEERERRQ
>NC_016593.1|WP_011230538.1|1132889_1133540_+|DUF1906-domain-containing-protein
MARGIWGVDSAQAVTDQLFQCVRTELGYPKFWGRYLSEVPNVSEGLTRDEIARIRSYGVKVLPIYNAFREAVGYANGQVAARNAVFHARRLGIPKNKLLFANIEDFFAVDAAWIAAWVETLYPTGYRPGLYADPTKGDFAAAYCEAVSRNNQVAVQAVIWSAAPRPGTTKEQKAPRYQPAAPPCSANVWVWQYGRDAEVCPVDTNLADRRLLDFLY
>NC_016593.1|WP_025039138.1|1133713_1135342_+|diguanylate-cyclase
MDRSVASLLDRIHEQYERWRTGPPLDGVELARFFNAVGRTAAVIGLSDIAAEAERLIHRLNGQTERQWTAEEALIEMVPLLRCFYEAGEAASATIPSSHRQGPKAAILLCGNDPLFFAYVRGALQTVPWRFTTIPSLEQAAASMFRLSPDCIIVSVKEGEWENPDLTVLLERAGQRPYLPVVIVRRDEGKEGRLKGYELGADDVITTPAADELFVRVRRLIEKKRKIDDLVLIDELTGVYNRKYLPRVYARLRSDLERYGAPSCLALLDLDHFKQVNDRFGHLAGDAVLQKLAAFLRQHTRGVDTVVRFGGEEFVVWLAKTSKSEARAVLERLQRQFAAEKIEADGALLSCTFSAGLVECDEPDRPLDYWLRLADKALYAAKRGGGNRIEEAAREKSGSSDEAPSQASTDRRRWAIAIVDDDELVRMMIADLVRKLVNEQGRKADIYEFGDGLSFLESPFYQSGRQSVVILDRVMPKMDGLEVLNRLRQERKPYKVMMLTSRQDERDIAHALNRGADEYVTKPFKWLELEARLRRLLKELDE
>NC_016593.1|WP_014195332.1|1135338_1136364_+|hypothetical-protein
MMALLVVFTAAIALFAVLIVLFLYLVVRKWRENRRQARLRVYKERHRLWLLRYLLGEEEQMLLPASPLEREAMMELLDHFASLLNGEQVQERIRTLAEMHFQGWLHRRLSSRHWSERMNALFLIEDLQVKAMLPEMERLYRSNRVTKGEAAKLLAIFAQFDYSPVIAYVLEPKYKLTEFSYRVIFGHMSERLLRQVEQRFDELPRAGKCAFIDMIGIRRRGERSFLLELLTSDELELRVRALKAMAEIGVSIEATKLDRHLRSPHWQERLMAVRLAGKCREERLLPLLYERLADRSFAVRSEAAASIVRLPGGRAMLHKAACTAEDRYARDMAKQWIGEEG
>NC_016593.1|WP_033007559.1|1136363_1137770_+|glycosyltransferase-family-2-protein
MVEGGQAFLSAIGHVVLIYMAVVLAFYTFLLVVAFIHLRRTRRLDDWEPYEELLDASYAKPISILVPAYNEEAGIVGSVRSLLAIEYPEYEVIVINDGSTDKTLKRLIDHFHLKPVYRVIRRQLAAKEIKAVYQSPDYPHLFVLDKENGGKADALNAGINAARYPYICSIDGDSVLERRAFLKVMKPMLESDGEVIASGGTVRIANGCRIERGEIVKVGLSRRPLVIMQTIEYLRAFLLGRLGLSRHNLLLIVSGAFGVFFKPWVIEAGGYTDTAGEDMELVVRLHRLAREKNEEKKIIYIPDPVCWTEAPETYGDLRRQRRRWHRGLLESLWMHRSMLFNPKYGSIGLLSLPYFWFIELLGPIVELMGYIVVVFSLFLGNLYVEFALLLLTVSVLYGSLLSAAAVLLEEWTERKFPSISDLVKLFFFALTETFWYRPLTAWWRCEGVIDAVRRKKQWGSIKRKGVSV
>NC_016593.1|WP_014195334.1|1137921_1138356_-|hypothetical-protein
MKPVQLTVDNIAKAIFTVNRHAKTALNPSFLYLLKKKAIEKLLEEGKAKKVGLHFSRNPRYSQQQSDVLVAVGDYYFHIPPTKQDFAALPHLGSLNDSYRNPPARMPLSEAKAILIAYTGLKEKPEQKPKRLTRPVFKRLGDRY
>NC_016593.1|WP_011230543.1|1138424_1139294_-|metallophosphoesterase
MHHIETTKLSRRAFLKKLARTSFSAALAMAAASGYARWIEPAELTVTHHALSHPLIPRSFAGVKLLQFSDLHLGHYYGLKRFYRIIGRINELGPDLVVFTGDLLHEANRYPHVNAVAEALAGVRAPLGKFCIYGNHDHGGYGTDIYRRLMERAGFRVLVNEHALVRRGHDAIAIAGSDDMMLGRPDWSKMTNGIPRATYTIALVHEPDGAIEARRFPIHVQLSGHSHGGQIQLPFIGPLITPPLSERYYEGFYHVGGLLLYVNRGLGTTRVPLRFFAPPELTVFSLTPG
>NC_016593.1|WP_011230544.1|1139437_1140205_+|2,4-dienoyl-CoA-reductase
MNGKVIIVTGGSSGMGKYMAKRFVSDGANVVITGRRAEALEEAKREIAAPDGGKVLTIPMDVRNPEQVAHMVERTDAEFGRIDALINNAAGNFICPAEKLSINGWNSVINIVLNGTFYCSREVGNYWIQRGLKGNIINIVATYAWHAGAGVIHSASAKAGVLAMTRTLAVEWGKKYGFRVNAIAPGPIERTGGAERLWESEEAERMTLESVPLGRLGTPEEIAAVASFLLSDEAAYINGACITVDGGQWLNRRPF

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Crispr_ID: NC_016593_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016593_3

2064940-2065907

Orphan

Consensus_repeat	Method
GTTTCAATCCCTCATAGGTACGATAAAAAC	CRISPRCasFinder
GTTTCAATCCCTCATAGGTACGATAAAAAC	CRT
GTTTTTATCGTACCTATGAGGGATTGAAAC	PILER-CR

14 spacers

The CRISPR arrays of NC_016593_3

>merge|NC_016593|3|2064940-2065907|CRISPRCasFinder,CRT,PILER-CR
GCTTCAGTCCCCCACAGGTACGATAAAAACGTATTCCTGTACCACGTGATTTAACTGTTGAACAGATGTTTCAATCCCTCATAGGTACGATAAAAACGGCGTCGGCGCGTATTTTTGGCCATTGATCGCTATAGTTTCAATCCCTCATAGGTACGATAAAAACCAAATTGGATCGGCTTGTACGGTCTGTCGGTGACTTGGAGTTTCAATCCCTCATAGGTACGATAAAAACTGCAATATACCGAGCCGATGAAAGTATGGAGTTGGGTTTCAATCCCTCATAGGTACGATAAAAACGAAAATATATTTCAGTCCCAAACCGTCACACTCAAGTTTCAATCCCTCATAGGTACGATAAAAACGATTAATAGGCTCGGCATTTTCAGGCAATTGGCCTTGGTTTCAATCCCTCATAGGTACGATAAAAACAGTAAGCGGCCAAGTGGAAAGGGTTTTCGCCCTAGAGTTTCAATCCCTCATAGGTACGATAAAAACGTACATCGAAGTCGACTCAATGGAACGCATCTTCTGTTTCAATCCCTCATAGGTACGATAAAAACCAACTAAAAGAATGGGAACGTTATTTTTCATTTACGGTTTCAATCCCTCATAGGTACGATAAAAACGGTGTAAAAAGGGAATGAATCCCGATGAAAATGTAATTTGTTTCAATCCCTCATAGGTACGATAAAAACGGTGTAAAAAGGGAATGAATCCCGATGAAAATGTAATTTGTTTCAATCCCTCATAGGTACGATAAAAACACAAGCATGAAAGCATCGAAATTCAAAAGAAACTTCGTAGTTTCAATCCCTCATAGGTACGATAAAAACTTATACGACTTACAACGTTTAGCTGGATTTGACGTGTTTCAATCCCTCATAGGTACGATAAAAACTGTGCCGCCGTCTGAGCCAACGTGCCGGCGCGCCACGCTTGTTTCAATCCCTCATAGGTACGATAAAAAC

>NC_016593|3|3|2064940-2065907|CRISPRCasFinder
GCTTCAGTCCCCCACAGGTACGATAAAAAC	GTATTCCTGTACCACGTGATTTAACTGTTGAACAGAT
GTTTCAATCCCTCATAGGTACGATAAAAAC	GGCGTCGGCGCGTATTTTTGGCCATTGATCGCTATA
GTTTCAATCCCTCATAGGTACGATAAAAAC	CAAATTGGATCGGCTTGTACGGTCTGTCGGTGACTTGGA
GTTTCAATCCCTCATAGGTACGATAAAAAC	TGCAATATACCGAGCCGATGAAAGTATGGAGTTGG
GTTTCAATCCCTCATAGGTACGATAAAAAC	GAAAATATATTTCAGTCCCAAACCGTCACACTCAA
GTTTCAATCCCTCATAGGTACGATAAAAAC	GATTAATAGGCTCGGCATTTTCAGGCAATTGGCCTTG
GTTTCAATCCCTCATAGGTACGATAAAAAC	AGTAAGCGGCCAAGTGGAAAGGGTTTTCGCCCTAGA
GTTTCAATCCCTCATAGGTACGATAAAAAC	GTACATCGAAGTCGACTCAATGGAACGCATCTTCT
GTTTCAATCCCTCATAGGTACGATAAAAAC	CAACTAAAAGAATGGGAACGTTATTTTTCATTTACG
GTTTCAATCCCTCATAGGTACGATAAAAAC	GGTGTAAAAAGGGAATGAATCCCGATGAAAATGTAATTT
GTTTCAATCCCTCATAGGTACGATAAAAAC	GGTGTAAAAAGGGAATGAATCCCGATGAAAATGTAATTT
GTTTCAATCCCTCATAGGTACGATAAAAAC	ACAAGCATGAAAGCATCGAAATTCAAAAGAAACTTCGTA
GTTTCAATCCCTCATAGGTACGATAAAAAC	TTATACGACTTACAACGTTTAGCTGGATTTGACGT
GTTTCAATCCCTCATAGGTACGATAAAAAC	TGTGCCGCCGTCTGAGCCAACGTGCCGGCGCGCCACGCTT
GTTTCAATCCCTCATAGGTACGATAAAAAC

>NC_016593|3|2|2064940-2065907|CRT
GCTTCAGTCCCCCACAGGTACGATAAAAAC	GTATTCCTGTACCACGTGATTTAACTGTTGAACAGAT
GTTTCAATCCCTCATAGGTACGATAAAAAC	GGCGTCGGCGCGTATTTTTGGCCATTGATCGCTATA
GTTTCAATCCCTCATAGGTACGATAAAAAC	CAAATTGGATCGGCTTGTACGGTCTGTCGGTGACTTGGA
GTTTCAATCCCTCATAGGTACGATAAAAAC	TGCAATATACCGAGCCGATGAAAGTATGGAGTTGG
GTTTCAATCCCTCATAGGTACGATAAAAAC	GAAAATATATTTCAGTCCCAAACCGTCACACTCAA
GTTTCAATCCCTCATAGGTACGATAAAAAC	GATTAATAGGCTCGGCATTTTCAGGCAATTGGCCTTG
GTTTCAATCCCTCATAGGTACGATAAAAAC	AGTAAGCGGCCAAGTGGAAAGGGTTTTCGCCCTAGA
GTTTCAATCCCTCATAGGTACGATAAAAAC	GTACATCGAAGTCGACTCAATGGAACGCATCTTCT
GTTTCAATCCCTCATAGGTACGATAAAAAC	CAACTAAAAGAATGGGAACGTTATTTTTCATTTACG
GTTTCAATCCCTCATAGGTACGATAAAAAC	GGTGTAAAAAGGGAATGAATCCCGATGAAAATGTAATTT
GTTTCAATCCCTCATAGGTACGATAAAAAC	GGTGTAAAAAGGGAATGAATCCCGATGAAAATGTAATTT
GTTTCAATCCCTCATAGGTACGATAAAAAC	ACAAGCATGAAAGCATCGAAATTCAAAAGAAACTTCGTA
GTTTCAATCCCTCATAGGTACGATAAAAAC	TTATACGACTTACAACGTTTAGCTGGATTTGACGT
GTTTCAATCCCTCATAGGTACGATAAAAAC	TGTGCCGCCGTCTGAGCCAACGTGCCGGCGCGCCACGCTT
GTTTCAATCCCTCATAGGTACGATAAAAAC

>NC_016593|3|2|2065007-2065907|PILER-CR
GTTTCAATCCCTCATAGGTACGATAAAAAC	GGCGTCGGCGCGTATTTTTGGCCATTGATCGCTATA
GTTTCAATCCCTCATAGGTACGATAAAAAC	CAAATTGGATCGGCTTGTACGGTCTGTCGGTGACTTGGA
GTTTCAATCCCTCATAGGTACGATAAAAAC	TGCAATATACCGAGCCGATGAAAGTATGGAGTTGG
GTTTCAATCCCTCATAGGTACGATAAAAAC	GAAAATATATTTCAGTCCCAAACCGTCACACTCAA
GTTTCAATCCCTCATAGGTACGATAAAAAC	GATTAATAGGCTCGGCATTTTCAGGCAATTGGCCTTG
GTTTCAATCCCTCATAGGTACGATAAAAAC	AGTAAGCGGCCAAGTGGAAAGGGTTTTCGCCCTAGA
GTTTCAATCCCTCATAGGTACGATAAAAAC	GTACATCGAAGTCGACTCAATGGAACGCATCTTCT
GTTTCAATCCCTCATAGGTACGATAAAAAC	CAACTAAAAGAATGGGAACGTTATTTTTCATTTACG
GTTTCAATCCCTCATAGGTACGATAAAAAC	GGTGTAAAAAGGGAATGAATCCCGATGAAAATGTAATTT
GTTTCAATCCCTCATAGGTACGATAAAAAC	GGTGTAAAAAGGGAATGAATCCCGATGAAAATGTAATTT
GTTTCAATCCCTCATAGGTACGATAAAAAC	ACAAGCATGAAAGCATCGAAATTCAAAAGAAACTTCGTA
GTTTCAATCCCTCATAGGTACGATAAAAAC	TTATACGACTTACAACGTTTAGCTGGATTTGACGT
GTTTCAATCCCTCATAGGTACGATAAAAAC	TGTGCCGCCGTCTGAGCCAACGTGCCGGCGCGCCACGCTT
GTTTCAATCCCTCATAGGTACGATAAAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_016593.1\|WP_014196020.1\|2061983_2062448_-\|tripartite-tricarboxylate-transporter-TctB-family-protein	unknown	unknown	gnl\|CDD\|377815
NC_016593.1\|WP_014196026.1\|2067696_2069787_-\|BglG-family-transcription-antiterminator	unknown	unknown	gnl\|CDD\|226234
NC_016593.1\|WP_014196019.1\|2060443_2061970_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225870
NC_016593.1\|WP_014196016.1\|2057016_2057952_-\|AEC-family-transporter	unknown	unknown	gnl\|CDD\|223751
NC_016593.1\|WP_014196014.1\|2055449_2056496_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_016593.1\|WP_014196012.1\|2052412_2053762_-\|GntP-family-permease	unknown	unknown	gnl\|CDD\|308194
NC_016593.1\|WP_014196017.1\|2058013_2058700_-\|response-regulator	unknown	unknown	gnl\|CDD\|226931
NC_016593.1\|WP_014196025.1\|2067247_2067691_-\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|227014
NC_016593.1\|WP_014196030.1\|2074682_2076143_-\|CoA-acylating-methylmalonate-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143404
NC_016593.1\|WP_021322439.1\|2071689_2072193_-\|DUF3368-domain-containing-protein	unknown	unknown	gnl\|CDD\|225269
NC_016593.1\|WP_013523968.1\|2072185_2072476_-\|UPF0175-family-protein	unknown	unknown	gnl\|CDD\|377095
NC_016593.1\|WP_014196023.1\|2063909_2064839_-\|Rpn-family-recombination-promoting-nuclease/putative-transposase	unknown	unknown	gnl\|CDD\|273806
NC_016593.1\|WP_021321533.1\|2058772_2060371_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|225827
NC_016593.1\|WP_011229531.1\|2072702_2074067_-\|ISLre2-family-transposase	unknown	unknown	gnl\|CDD\|284250
NC_016593.1\|WP_014196031.1\|2076344_2077532_-\|iron-containing-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|341473
NC_016593.1\|WP_014196028.1\|2070098_2071547_-\|PTS-mannitol-transporter-subunit-IICB	unknown	unknown	gnl\|CDD\|225123
NC_016593.1\|WP_014196032.1\|2077726_2079436_-\|sigma-54-dependent-Fis-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|226350
NC_016593.1\|WP_014196021.1\|2062502_2063543_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270234
NC_016593.1\|WP_014196013.1\|2053918_2055463_-\|gluconokinase	unknown	unknown	gnl\|CDD\|130381
NC_016593.1\|WP_014196024.1\|2066087_2067248_-\|mannitol-1-phosphate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|235031

Protein	Function_ID	Function_description	E-value
NC_016593.1\|WP_014196020.1\|2061983_2062448_-\|tripartite-tricarboxylate-transporter-TctB-family-protein	gnl\|CDD\|377815	pfam07331, TctB, Tripartite tricarboxylate transporter TctB family. This family consists of several hypothetical bacterial proteins of around 150 residues in length. This family was formerly known as DUF1468.	5.20207e-13
NC_016593.1\|WP_014196026.1\|2067696_2069787_-\|BglG-family-transcription-antiterminator	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	2.12944e-65
NC_016593.1\|WP_014196019.1\|2060443_2061970_-\|hypothetical-protein	gnl\|CDD\|225870	COG3333, COG3333, Uncharacterized protein conserved in bacteria [Function unknown].	0
NC_016593.1\|WP_014196016.1\|2057016_2057952_-\|AEC-family-transporter	gnl\|CDD\|223751	COG0679, COG0679, Predicted permeases [General function prediction only].	7.37045e-32
NC_016593.1\|WP_014196014.1\|2055449_2056496_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	9.31813e-110
NC_016593.1\|WP_014196012.1\|2052412_2053762_-\|GntP-family-permease	gnl\|CDD\|308194	pfam02447, GntP_permease, GntP family permease. This is a family of integral membrane permeases that are involved in gluconate uptake. E. coli contains several members of this family including GntU, a low affinity transporter, and GntT, a high affinity transporter.	9.26815e-171
NC_016593.1\|WP_014196017.1\|2058013_2058700_-\|response-regulator	gnl\|CDD\|226931	COG4565, CitB, Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms].	1.13943e-89
NC_016593.1\|WP_014196025.1\|2067247_2067691_-\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|227014	COG4668, MtlA, Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and metabolism].	1.16022e-59
NC_016593.1\|WP_014196030.1\|2074682_2076143_-\|CoA-acylating-methylmalonate-semialdehyde-dehydrogenase	gnl\|CDD\|143404	cd07085, ALDH_F6_MMSDH, Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2. Methylmalonate semialdehyde dehydrogenase (MMSDH, EC=1.2.1.27) [acylating] from Bacillus subtilis is involved in valine metabolism and catalyses the NAD+- and CoA-dependent oxidation of methylmalonate semialdehyde into propionyl-CoA. Mitochondrial human MMSDH ALDH6A1 and Arabidopsis MMSDH ALDH6B2 are also present in this CD.	0
NC_016593.1\|WP_021322439.1\|2071689_2072193_-\|DUF3368-domain-containing-protein	gnl\|CDD\|225269	COG2405, COG2405, Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only].	1.46092e-32
NC_016593.1\|WP_013523968.1\|2072185_2072476_-\|UPF0175-family-protein	gnl\|CDD\|377095	pfam03683, UPF0175, Uncharacterized protein family (UPF0175). This family contains small proteins of unknown function.	2.75843e-16
NC_016593.1\|WP_014196023.1\|2063909_2064839_-\|Rpn-family-recombination-promoting-nuclease/putative-transposase	gnl\|CDD\|273806	TIGR01784, Uncharacterized_protein_pSLT051, conserved hypothetical protein (putative transposase or invertase). Several lines of evidence suggest that members of this family (loaded as a fragment mode model to find part-length matches) are associated with transposition, inversion, or recombination. Members are found in small numbers of genomes, but in large copy numbers in many of those species, including over 30 full length and fragmentary members in Treponema denticola. The strongest similarities are usually within rather than between species. PSI-BLAST shows similarity to proteins designated as possible transposases, DNA invertases (resolvases), and recombinases. In the oral pathogenic spirochete Treponema denticola, full-length members are often found near transporters or other membrane proteins. This family includes members of the putative transposase family pfam04754.	4.88338e-11
NC_016593.1\|WP_021321533.1\|2058772_2060371_-\|sensor-histidine-kinase	gnl\|CDD\|225827	COG3290, CitA, Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms].	0
NC_016593.1\|WP_011229531.1\|2072702_2074067_-\|ISLre2-family-transposase	gnl\|CDD\|284250	pfam06782, UPF0236, Uncharacterized protein family (UPF0236).	0
NC_016593.1\|WP_014196031.1\|2076344_2077532_-\|iron-containing-alcohol-dehydrogenase	gnl\|CDD\|341473	cd08194, Fe-ADH-like, Iron-containing alcohol dehydrogenases-like. This family contains iron-containing alcohol dehydrogenase (Fe-ADH) most of which have not been characterized. Their specific function is unknown. The protein structure represents a dehydroquinate synthase-like fold and belongs to the alcohol dehydrogenase-like superfamily. It is distinct from other alcohol dehydrogenases which contain different protein domains. Alcohol dehydrogenase catalyzes the reduction of acetaldehyde to alcohol with NADP as cofactor. Its activity requires iron ions.	0
NC_016593.1\|WP_014196028.1\|2070098_2071547_-\|PTS-mannitol-transporter-subunit-IICB	gnl\|CDD\|225123	COG2213, MtlA, Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism].	0
NC_016593.1\|WP_014196032.1\|2077726_2079436_-\|sigma-54-dependent-Fis-family-transcriptional-regulator	gnl\|CDD\|226350	COG3829, RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms].	5.34091e-180
NC_016593.1\|WP_014196021.1\|2062502_2063543_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	2.55695e-94
NC_016593.1\|WP_014196013.1\|2053918_2055463_-\|gluconokinase	gnl\|CDD\|130381	TIGR01314, gntK_FGGY, gluconate kinase, FGGY type. Gluconate is derived from glucose in two steps. This model describes one form of gluconate kinase, belonging to the FGGY family of carbohydrate kinases. Gluconate kinase phosphoryates gluconate for entry into the Entner-Douderoff pathway. [Energy metabolism, Sugars].	0
NC_016593.1\|WP_014196024.1\|2066087_2067248_-\|mannitol-1-phosphate-5-dehydrogenase	gnl\|CDD\|235031	PRK02318, PRK02318, mannitol-1-phosphate 5-dehydrogenase; Provisional.	0

>NC_016593.1|WP_014196023.1|2063909_2064839_-|Rpn-family-recombination-promoting-nuclease/putative-transposase
MAIDHDRLFKELIQTFFEEFLLLFFPDMHEHIDFSHLSFLSEELFTDVTAGEKYRVDLLVETKLKGEDGLIIVHVENQSYVQPSFPERMFIYFSRLFEKYRTRIVPIAVFSHDTLREEPSVFSIEFPFGDVLQFRFFPVELRKKHWRDYIRHDNPIAAALLGKMGYTESEKIELKKEFLRMLVRLELDEARQRLLLGFFETYVKLSEEEEQQLQREVKEMETTEKEKMLELIISYEQRGRKQGLEEGIKRGIEQGIKQGMKQGMKQGMKQGMKQLIRNMARKGMKVEDIARLVDLPEQDVWELLEEQGN
>NC_016593.1|WP_014196021.1|2062502_2063543_-|tripartite-tricarboxylate-transporter-substrate-binding-protein
MKKKRWWGLLAAGMMTLALAACGGNESAGSKPSGSNSGSSASNYPTKPITIVAPSGAGGGWDLTARAITKVLDETGLVKQTMTVENKPGGGGAVFMAEYATQDVKNDYKLFVNSPPIIINNLKKEGNSPFGYKDTTPLAQLTKDFGAIVVKADSKFQTLTDLLNTIKQDPKSVTVAGGSAPGSMDHLVAILPIYKSGIDPKSVKYVSYDGGGEAMAALLGGNADVIATDASSVGEYLKAGKVRVLAVSAPERLGGVLKDVPTLKELGIDAEFTIWRGVFGPKQMSREAKAFWEETLKKLSEHEKWKEELQKQGWVAEYRNSDEFTKFLQEQEQQIGDLLKSLGMHK
>NC_016593.1|WP_014196020.1|2061983_2062448_-|tripartite-tricarboxylate-transporter-TctB-family-protein
MNKTADRIAAVAFLAVGSLFMAESLRLSKSAYGSAVGPNVFPFLLGLVLALLSIKLLFETRGYKDYKDSVGEKPPRQYKKFLIIFIAAVFYATLLETVGYVITTFLFLVIGFQTMERGALWKSIAIAAGFSLGVYGLYVKLLQGTLPSWPVWFQ
>NC_016593.1|WP_014196019.1|2060443_2061970_-|hypothetical-protein
MSTLSFLLDGFQTALQPHNLFFAFLGVLIGTAVGVLPGIGPMSGVALLIPVTASMTSGLSPEQAAASSIILLAGVYYGAMYGGSTTSILLNTPGESSSVVTTLDGYQMARQGRAGAALAIAAIGSFVAGIVSLIGLVLLAQPLSNVALKFGPAEYFSLMLLGLAAVSGLAGKSMTKAWIMTVFGLLLSTIGLDNVSGVARFTYDISYLYGGLEFLTVAVGLFALGEVFKSILCNETNDGDIAKIGRVLPTKADLKESAGPIARGSLLGFFIGVLPGAGATLASFFSYILEKKVSKHPEKFGQGTIAGVAAPESANNGASGGAMIPLLTLGIPGSGTTAILMGALIMYNVQPGPLLFDEHPAVAWGLIASMFIGNVMLLILNMPLVKVFAKIIQTPTKYLLPLIIAISVFGVYAVQVTTFDVFLLLAFGLLGYWLAEHDYPLAPLVLGLVLGPMIENNMRRALTASNGDYLVFFEKPISLVLLVIAFLWIAVPFVMKLRGKSVVINEDM
>NC_016593.1|WP_021321533.1|2058772_2060371_-|sensor-histidine-kinase
MKLQTRLMVIICSLLLLVIVVLTFLFQHMFATTLKQQIGMRALNVAETVASTPLVREAFRDPNPSVRLQPFAEHIRRKTGAEYVVIGNRKGIRYAHPLPDRIGKHMVGGDNGEVLKGKAIISEAVGSLGPAIRGKAPIFDENGHVIGIVSVGFLLEDIQRTVWSYRMKMFLFSVFALFLGAVGAMAIASTVKKSIHGLEPEEIGLLYQEKQAILEAIREGIVAINQEGTITMVNQTALKLLGYEKEHSVLGMPILRLIPHSRLPEVIRTGRAEYDDEMVLGRETVIANRIPIKDKQGRVIGAVSTFRNKSELYRLTKELSQLRVYADALRAQTHEFSNKLYLISGLIQLESYEEALELITKETNLQQNIIRFVMKEIPDPIIGGLLIGKFNRAHELKITFEIDRESSFRDVPPWIDRDHLVTIIGNLLDNAMEAVLHNGKEEKRVTIFLTDLGDDLIIEVEDNGLGVDPDVAERIYDRGFSTKANGLRGYGLDLVKKALAMLGGQITYQSKQGEGTVFTVIIPKRSGRANPC
>NC_016593.1|WP_014196017.1|2058013_2058700_-|response-regulator
MIRVLIIEDDRRIAEINRRFVEKVNGYEVVGIATNAEEARELTEVLQPDVLLLDVYFPDMNGLSFLKWVRERFSNIDIIMITAAREVDALKQALHGGVFDYIIKPIMFDRFAETLHRYKEYYDKMQQWMKEKEWIDQEDVDKLIGREAPVRDQPMLPKGIQPLTLEKVLMVVKRCQDGVTAEEVGRQIGTSRTTARRYLEYLVSTGQVLADIVYGSVGRPERIYKKRG
>NC_016593.1|WP_014196016.1|2057016_2057952_-|AEC-family-transporter
MYIFVSILLQVMIPMLLIVGLGAGLHRFFRLDLNTLSKLNMYVLLPAVAFINVYDSELNGKVLAAILGFLLLQNGGLMVLSRIMAKLFKLERSMAAVFQNTVVLNNSGNFGIPVSQLVFHQHPLGATIQIIVTIFQNFLTNTYGVYQFVSGNGKSGKWAAEIWKNPVLHALLFGVVCRWLHVPIPSFLWTPLRRVADAFLAIALFTLGAQIAYARFNALPPLVYASVFGRLVLSPLLAASLIFLLGIDGVTAQALLIASSYPCSRNTALYALEYDCHPDYAAQAVLVSTLLSAITVTGVVYAARLLFPIAG
>NC_016593.1|WP_014196014.1|2055449_2056496_-|LacI-family-DNA-binding-transcriptional-regulator
MKKVTMADVAKLANVSKSTVSQYLNKRYEYMSEETRKRIAQAIEELGYQPNVIARSLKQKTTATIGVIVFNMLHMLTTQVLHAIEEECQKRGFQVIVCNSGDDPEKEKKYVDMLLAKQVDGLIVFPTGKNEEVYRRLVEERFPLVFVDRMVPGVEADSVLLDNAGAAEMAVQYFASYGYERIAIVTPPLVPYNVPRMERFEGFRAAMEKRGFEVGDQNVIAAEPAALPGELKKRFMESERPNALFAINDLTLMGVLRFVKETGIRMPDELAIINIDDVPFADIYTPALTTIAQPTFAMGKKAAERVFEQMDSNHADSPRVFRFSPALVERTWIKRGNGKEGRRNDEDS
>NC_016593.1|WP_014196013.1|2053918_2055463_-|gluconokinase
MKIHERVVIGVDIGTTSTKAVVFGEQGRVLASHAIDYPIIQPHPGFAEQDPEELFAAVIQVVGAVTVRYGIRPKQVKAMGLSAAMHSIMALDGSGRPLTRLIIWADNRSVVQAERLLKEHHGLDIYRRTGTPIHPMSPLPKLLWLKEKQPDVFRQARWFVSVKDYVLYRLYGDYIADHSLASATGLFRLDTLDWDEGVLSFLGISREQLPRLVPAIHILQGMKKEWADKMGVSADVPVVIGASDGVLANVGVGAVLPGEAAITIGTSGAVRTIATKPTTDEKGRTFCYALTPGYWVVGGPTNNGGILLRWLRDEFGAQEREVAKKLGMDPYDLLTKYAERVPPGSEGLVFLPFLSGERAPYWNANARGTFFGLGLHHRREHLIRAVMEGVCFSILSVALAIRDATGPMSEIRVSGGFAKSPFWRQMLADMLGKPLIVPQTHEASALGAAAVALHALGELPSLEMVKPWIGTMARHEPNEAHTLIYAELFDLYARLYERLKEEFDVIAAFQRRNG
>NC_016593.1|WP_014196012.1|2052412_2053762_-|GntP-family-permease
MGIAIVIAAIIVLLLLITAVKMHPFVALILVSVGVGLAMGMPLVAPSPETPGIIDSIKAGLGNTLGFLAIVLALGTMLGKMMAESGGAERIAKTLIDRFGQKRVHWAMMVVAFLVGIPVFFQVGFVLLIPLVFTIAMETGISLVTIGIPLVAGLSVVHGLVPPHPAAMAAVGIFQADVGKTILYSIIVGLPTAIIAGPLYGKWIGSRMHKSVPAEIAEQLVQHKEARELPGFGNTLFTILLPVILMLIASIANVTLDQKSEAAKVLRFIGDPIVALLIATVYSFFSLGYARGFHRDAVLKFANDCLGPVANILLVIGAGGAFNKVLLDSGIGNQIAEVAKHSHLSPLLLGWGIAALIRVATGSATVSMMTAAGIVAPIAATMPGTNAELLVLATGAGSLILSHVNDSGFWMIKEYFGMTVKETLMTWTAMETIISVVAFIFVLLLNVVL
>NC_016593.1|WP_014196024.1|2066087_2067248_-|mannitol-1-phosphate-5-dehydrogenase
MRAVHFGAGNIGRGFIGSLLAASGYDVVFVDVNEQIVRLLKERGEYRVIVAGERREEQWVRGVSALNSQTEREAVIEAIADADLVTTAVGPHILPAIAPVIAAGLERRFTVHQKPLHVIACENMIGGTETLKMHVFAHLSTAGQQLADENVGFLNCAVDRIVPNQTNDDPLAVTVEPFFEWTIETRNVIGTVPPIQGAHFVADLEPYIERKLFTVNTGHALAAYLGYLRNYKTVQEAMNDEGIRLNVEQALSESGAVLLKKHGWHEEEHRSYIKTTIGRFTNPSLSDDIVRVARSPIRKLGPNDRLIAPATQYCTLFGSVPAGLAKGIAALLRFDDASDAEAAALQQTIAHHGIEGALRQYAGLESAHPLVAAVREEYGRMEKNKS
>NC_016593.1|WP_014196025.1|2067247_2067691_-|PTS-sugar-transporter-subunit-IIA
MLTHSILNKENIVLNAQPKTKEEAIRLAGEVLVKQGYVAPAYVDAMLEREELTSTYIGNNVAIPHGTEAAKALVKQSGISIVQVPDGVDFGGGNMATIVIGIAGKDGEHLDILSKLALVCAEADNVAAMANAKTAEEILALLHEVNG
>NC_016593.1|WP_014196026.1|2067696_2069787_-|BglG-family-transcription-antiterminator
MYVSARERKLLERLLADDRDITVGELAEELNVSARTVHRDLQGLESVFRRYGLKLAKRAGVGIRLVGEEEKKQALAAELFRLSHHEYTPEERQLMILIALLEANEPVKLVTLAHDLNVTVATVSLDLDKLEQTVEAYGLSLIRKRGYGVELAGSESVKRRLMSDLLFRHVDEHEFLALMKETIQKRTDAPLDTVAEKLLGLVDRKKLAVIEQQIEQVKEKLPFTMADSSYIAFVVHLALAMERIKRGEAIHFDPRDLQALQATKEYEIAHELAESLEKVFDVDIPNEEVGYMTMHLMGAKWRSRQGMVMEEPSLAVGMKAQQLIRFVSDKLGVDLSADRTLYEDLVVHLKPALYRLEHGMGVANPLLDPIKQDYAELFAIVSDGARQLFGGIPIPDEEIGYLVLHFAAALMREKKGWRVLVICSSGLGTAKILATRLKKEIPDIVSLEQASAFEWKGKDVSAYDLVISTVPLPEEYGPHIVVSPMLTEEEARKIRECLERKSAAEKRMRKESTARRNRPAIDTMKAVRRISETIVHILDGFSLEVVKRRSVHEILTDACRRLERSGVVVDADVVIEELRRRESLGGLGVPGTTLALYHARSFAVLRPSLTMYRLDSPQTVAGMDGEPMEINTVVLLLGPADADEEVLSVLSHVSTLLVKNEQSAATLAYGGEDEVYSLISGHLEQFFDDYWISMKE
>NC_016593.1|WP_014196028.1|2070098_2071547_-|PTS-mannitol-transporter-subunit-IICB
MTHTTGNETGFRVKIQRFGGYLSGMIMPNIGAFIAWGLITALFIPTGWLPNETFAKLVGPMITYLLPLLIGYTGGKMVYDVRGGVVGATATMGVVVGSEIPMFLGAMIMGPLGGYVIKKVDGLFQGKVKQGFEMLVNNFSAGIVGGVLTLLAFKGVGPVISVISKTLAAGVEKIIDWHLLPLANLFIEPGKVLFLNNAINHGILSPLGVEQAAKTGKSILFLLETNPGPGLGILLAYWLFGKGMAKQSAPGAVIIHFLGGIHEIYFPYILMRPILILAAMAGGVSGVFTFTVLHAGLVAVPSPGSIFALLAMTPKGNYFGVLAGVFVAAAVSFLVASIFLKAAKQSEEEEELTKATEKMEQLKGKKSQVAAALQQKEAASATVAQAVPGRVKKIVFACDAGMGSSAMGASILRNKVQKAGLDIEVTNTAINQLPADADIVVTHQNLTDRAKAKLPNAYHVSVENFLNSPKYDELIEQLKKNA
>NC_016593.1|WP_021322439.1|2071689_2072193_-|DUF3368-domain-containing-protein
MSRVTVNSTPIIGLSIVGQLTLLSELFDEVYVPEAVYQEIVHNHAPRHYGKEELKRLVSEGVFRLYHVKNRSLVESLYGKFHAGELEVIIGAKELGAQVVVIDEHAARSLSKQFLLRPIGTIGVLILGKKNRKIAEVKPLLDTLLENGFYLSQRLYREALSLAEETP
>NC_016593.1|WP_013523968.1|2072185_2072476_-|UPF0175-family-protein
MDYFQVNLPKEFLPAINELEGNTVEAKIKLSLAIGLFVGKQVTLAKAAELAGKSLGEFIDVLRSKAIPWMEYTEEHIKDDWDTVQKLSKENRDHNE
>NC_016593.1|WP_011229531.1|2072702_2074067_-|ISLre2-family-transposase
MKHLTTEWPLLKELEEQLVRTLQKVFAVLLAALLEEIDQQLAEARDKRRYQLKDKRPTTIQTLFGEVTFRRNYYYDRQAGAYTFLLDAELGFDGAQSISPCLEETAVELAVECSSYRKAARTLESIVGYAVMSHEAIRQLVLEASVSLHHPVSKRHGRVLFVEADGLFISRQGKGKRAKEEKILAIHEGWKRNGSQLELVNRRHYLHEGEGDVWERFEEWLMNEYAYDPCRDLLIINGDAASWITACREYFGKRACFQLDRFHVARELRQCLSGHPRWREVRKKLAKQDEEGLLVELNSAVGTLEDEGKEQQLAALIRRIESMPGCIRDYREWLSEQGVETTGMRPMGHAESVMSRFAHRVKSRRSWKDQGLRAFLRAMAARIDGIGWRKGRWEEQEPQSAVSASTKSKRIEQAKRKAGRLWADVMRQNIPYLQQSSGTPIHQALSALRDGGWV
>NC_016593.1|WP_014196030.1|2074682_2076143_-|CoA-acylating-methylmalonate-semialdehyde-dehydrogenase
MSSVTETKTLKNFIGGQWVASTSGKEEIVPNPATGEVLAKVPLSSLEELDAAVAAAKEAFREWRKVPVPRRARILFRYQQLLVEHWDELARLVTLENGKVYEDAYGEVQRGIECVEFAAGIPTLMMGQQLPDIATDIESGMYRYPLGVVAGITPFNFPMMVPCWMFPLAIACGNTFVLKPSERTPMLANRLAELFTEAGLPAGVLNIVHGAHEVVNGILEHKDIKAVSFVGSQPVAEYVYKTAAAHGKRVQALAGAKNHSIVMPDADLDMAVTNIINAAFGSAGERCMACSVVVAVGDIADELVERLKEAADRIQIGNGLDKGVFLGPVIRESHKERTIKYIEIGEKEGALLVRDGRRDSATSGKGYFIGPTIFDHVKPGMAIWTDEIFAPVLSVVRARDLDEAIEIANRSEFANGACIYTDSAKAIRQFREEIDAGMLGVNVAVPAPMAFFPFSGYKNSFYGDLHANGRDGVEFYTRKKMVTARY
>NC_016593.1|WP_014196031.1|2076344_2077532_-|iron-containing-alcohol-dehydrogenase
MYELLVPSRVVYGRNTFAEVGPQAKALGTKALIVSDPVMEKIGLVARCEQYLQQVGMTFAKYTGVDTEPTDVHVKEALDVCRSEQCDVIIALGGGSSIDAAKAVAVMITNEGTISDYVGNQKRFTEKPLPLIAIPTTAGTGSEVTKVTVIIDTKTDVKMMISQPALLPAVAIVDPLLTISCPPSVTAATGVDALCHAIEAYISRRAHPVTDVLALSAIEAIIGHLRRAYENGQDIEAREKMAIAAMKAGMAFSNASVTLVHGMSRPIGALFHVPHGVSNAMLLPGVLEFTKDSAIERLAVIARIIKPPLKDVSDTEAAEALVEEVKQLCRDLHIPNMKTWGIDKTAFDKVVDKMAADALASGSPANNPKVPTHEEIVALYHYCYDYQYDTKTVSS
>NC_016593.1|WP_014196032.1|2077726_2079436_-|sigma-54-dependent-Fis-family-transcriptional-regulator
MASDCSALPTVVCRQTLQEVMQRMAARGLESVNVIDEHDRTVGRCTWRMMLRAAADGLDRSMPIGEVLMAFSDKWETKQEGVCAAMPMSESDSKATNELERLRRELEETHRLAETMKTVLDAAYEGVVVVDEDGVVREINRAYCQFLGIRREEAIGKHVTEVIENTRLHICVQSGIPERGYIQKIYGQPMVVHRIPIWRDGKVIGAIGMLIFQGVSEVYEIFRRLQELSREASRKEKKEAKPQETAASAPKGIERIIGRHPSIAAVKQMIRRAARVPSTVLITGESGTGKEVVARAIHEAGPHADGPFVSVNCAAIPESLLEAELFGYEDGAFTGAKKGGKPGKFQLAHGGTLFLDEIGDMPLAMQAKILRVLEEKKVEKVGGLYETKVDVRIIAATNKPLEEMVRNGTFREDLFYRLNIIRIHLPPLRERKTDIPALLAYHMDRMCRQFGVALKSFTKEAMEVLVHYSWPGNVRELVNVVEWLISMGEGEKVEREHLPSYLSTVQPAASSLPNGGVKMADRWKEMVYQSERERIAAALVAAGGNKAEAARRLGIHRSTLYEKLKKYGL

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Crispr_ID: NC_016593_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016593_4

2999352-2999434

Unclear

Consensus_repeat	Method
ATGGCCACCAAAGACGAACTCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_016593_4

>merge|NC_016593|4|2999352-2999434|CRISPRCasFinder
ATGGCCACCAAAGACGAACTCGCCGAGCTCCGATCCAAAGTGGACGACATCGAAGCGAAAATGGCCACGAAAGACGAACTCGC

>NC_016593|4|4|2999352-2999434|CRISPRCasFinder
ATGGCCACCAAAGACGAACTCGC	CGAGCTCCGATCCAAAGTGGACGACATCGAAGCGAAA
ATGGCCACGAAAGACGAACTCGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_016593.1\|WP_014196631.1\|3015021_3016323_-\|DnaD-domain-protein	unknown	unknown	gnl\|CDD\|226445
NC_016593.1\|WP_014196630.1\|3012932_3013841_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|223769
NC_016593.1\|WP_025038904.1\|2995580_2996561_-\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376439
NC_016593.1\|WP_025039336.1\|3016560_3017442_+\|nuclease	unknown	unknown	gnl\|CDD\|214615
NC_016593.1\|WP_011232356.1\|2993241_2993796_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|224584
NC_016593.1\|WP_025038903.1\|2996553_2997552_-\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376439
NC_016593.1\|WP_014196625.1\|3000070_3000532_-\|DUF3221-domain-containing-protein	unknown	unknown	gnl\|CDD\|371575
NC_016593.1\|WP_025038910.1\|2987627_2988797_-\|glucose-1-phosphate-adenylyltransferase	unknown	unknown	gnl\|CDD\|179997
NC_016593.1\|WP_025038905.1\|2994025_2995528_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|375438
NC_016593.1\|WP_033007344.1\|2988678_2990721_-\|1,4-alpha-glucan-branching-enzyme	unknown	unknown	gnl\|CDD\|235445
NC_016593.1\|WP_011232385.1\|3012143_3012962_+\|protein-glutamine-gamma-glutamyltransferase	unknown	unknown	gnl\|CDD\|235109
NC_016593.1\|WP_014196627.1\|3002639_3004004_+\|ISLre2-family-transposase	unknown	unknown	gnl\|CDD\|284250
NC_016593.1\|WP_011232387.1\|3013967_3014645_+\|MgtC/SapB-family-protein	unknown	unknown	gnl\|CDD\|224204
NC_016593.1\|WP_011232353.1\|2990897_2991848_+\|cation-transporter	unknown	unknown	gnl\|CDD\|224151
NC_016593.1\|WP_014196619.1\|2991980_2992607_+\|LysE-family-translocator	unknown	unknown	gnl\|CDD\|224199
NC_016593.1\|WP_011232373.1\|2997582_2998524_-\|iron-siderophore-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238566
NC_016593.1\|WP_013144370.1\|3017654_3017906_-\|hypothetical-protein	unknown	unknown	unknown
NC_016593.1\|WP_012749415.1\|3000977_3002258_-\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376564
NC_016593.1\|WP_023633412.1\|2992944_2993232_-\|hypothetical-protein	unknown	unknown	unknown
NC_016593.1\|WP_014196629.1\|3011886_3012099_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_016593.1\|WP_014196631.1\|3015021_3016323_-\|DnaD-domain-protein	gnl\|CDD\|226445	COG3935, DnaD, Putative primosome component and related proteins [DNA replication, recombination, and repair].	1.59345e-16
NC_016593.1\|WP_014196630.1\|3012932_3013841_-\|DMT-family-transporter	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	2.36094e-17
NC_016593.1\|WP_025038904.1\|2995580_2996561_-\|iron-ABC-transporter-permease	gnl\|CDD\|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	2.92946e-94
NC_016593.1\|WP_025039336.1\|3016560_3017442_+\|nuclease	gnl\|CDD\|214615	smart00318, SNc, Staphylococcal nuclease homologues.	1.47595e-17
NC_016593.1\|WP_011232356.1\|2993241_2993796_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	3.3296e-19
NC_016593.1\|WP_025038903.1\|2996553_2997552_-\|iron-ABC-transporter-permease	gnl\|CDD\|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	3.60716e-91
NC_016593.1\|WP_014196625.1\|3000070_3000532_-\|DUF3221-domain-containing-protein	gnl\|CDD\|371575	pfam11518, DUF3221, Protein of unknown function (DUF3221). This family of proteins with unknown function appears to be restricted to Bacillus. Some members in this family of proteins are annotated as YobA however this cannot be confirmed. YobA is a protein with unknown function.	5.75925e-22
NC_016593.1\|WP_025038910.1\|2987627_2988797_-\|glucose-1-phosphate-adenylyltransferase	gnl\|CDD\|179997	PRK05293, glgC, glucose-1-phosphate adenylyltransferase; Provisional.	0
NC_016593.1\|WP_025038905.1\|2994025_2995528_-\|hypothetical-protein	gnl\|CDD\|375438	pfam17936, Big_6, Bacterial Ig domain. This domain is found in a wide variety of extracellular bacterial proteins often in multiple tandem copies.	5.77039e-09
NC_016593.1\|WP_033007344.1\|2988678_2990721_-\|1,4-alpha-glucan-branching-enzyme	gnl\|CDD\|235445	PRK05402, PRK05402, 1,4-alpha-glucan branching protein GlgB.	0
NC_016593.1\|WP_011232385.1\|3012143_3012962_+\|protein-glutamine-gamma-glutamyltransferase	gnl\|CDD\|235109	PRK03187, tgl, transglutaminase; Provisional.	2.07778e-159
NC_016593.1\|WP_014196627.1\|3002639_3004004_+\|ISLre2-family-transposase	gnl\|CDD\|284250	pfam06782, UPF0236, Uncharacterized protein family (UPF0236).	0
NC_016593.1\|WP_011232387.1\|3013967_3014645_+\|MgtC/SapB-family-protein	gnl\|CDD\|224204	COG1285, SapB, Uncharacterized membrane protein [Function unknown].	6.68956e-56
NC_016593.1\|WP_011232353.1\|2990897_2991848_+\|cation-transporter	gnl\|CDD\|224151	COG1230, CzcD, Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism].	1.71392e-100
NC_016593.1\|WP_014196619.1\|2991980_2992607_+\|LysE-family-translocator	gnl\|CDD\|224199	COG1280, RhtB, Putative threonine efflux protein [Amino acid transport and metabolism].	3.72161e-43
NC_016593.1\|WP_011232373.1\|2997582_2998524_-\|iron-siderophore-ABC-transporter-substrate-binding-protein	gnl\|CDD\|238566	cd01146, FhuD, Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA-like protein is comprised of two globular subdomains connected by a long alpha helix and binds its specific ligands in the cleft between these domains.	8.0259e-63
NC_016593.1\|WP_012749415.1\|3000977_3002258_-\|IS110-family-transposase	gnl\|CDD\|376564	pfam01548, DEDD_Tnp_IS110, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family includes an amino-terminal region of the pilin gene inverting protein (PIVML) and of members of the IS111A/IS1328/IS1533 family of transposases. The C-terminus is represented by family pfam02371.	4.77253e-32

>NC_016593.1|WP_011232373.1|2997582_2998524_-|iron-siderophore-ABC-transporter-substrate-binding-protein
MLQKKWTSLLAMLMALFVLLVPLAQPAAPVEAASKTRVFKTELGKLVIKGTPKRIVTLSMAGTDAVVTLGLKPVGYTISNSGTVPTYLRNKLKGVPSVGALSAPSLERIAALKPDLIIIDHEFEFHKAIIPQLKKIAPVAGFRANSYKEAMNQLLVLGDILGRKAKAKSFVNQFYKELKSQQAKLKDKNLRVLGFFVNKDGINVWQDNSFSGSIFTALKADYAFKEKGDEYSDFKTVSLERILEIDPDVLFAYTDPGKNDLKKVKANPIWSQLKAVKKKRVVEVNRDLWSRSRGPLAAKLIVKEAASILKRYQ
>NC_016593.1|WP_025038903.1|2996553_2997552_-|iron-ABC-transporter-permease
MTYGKRAIWISSMLVLGIILLIIVSLVSGPFFVPIPKVLDVLLHDDGSKARTVVWELRFPRALLAVLIGASLAVAGAMMQCLTKNPMAEPKIMGVSAGAAAMVVLIEYFFAGLPLLFFSPLVFLGAAVGGALVYSLSLKRGTLSPVRLTLAGVAVSAFLHAITVGILVLLGQDAAAVYAWLAGGLNGLTWRHVSLIAPWSLAGLLLSIMIASKMDLLELGDDTAKGLGVHVGILKTVMAVMIIILAGSAVSVSGVIGFIGLIIPHIVRKMVGVNYTYIVPVSALCGGMLLLTADLLARLVAQPIELPVGVFTAAIGCPYFLYLIRKQGEWNA
>NC_016593.1|WP_025038904.1|2995580_2996561_-|iron-ABC-transporter-permease
MRKRDVGLVAGLALLLVIIVPLSACFGDVKIPVSQVWEAFFNRKSSLNGEIVWEYRLPRILVGLFVGANLAVSGALLQAVTQNPLAAPNVIGMTAGASFFAVLALLIIPHFPVSGLPFVTFFGALFAGLCVYAFAWKKGMDKGRFALSGIAFDALFQAVITGILVFATKGIDAAVIWLAGSLWGRTWEHVFLIVPWSVIGLGFAYLCYRRMNVLQLHDDVAASLGLRVQAARFLIFLIAVGLCGSAVAVSGPIGFVGLVIPHLARLLTRADYQRLIPVSALLGAILMISADTAGRTIAAPIEIPVGILTAFLGAPYFLFLLRRAKL
>NC_016593.1|WP_025038905.1|2994025_2995528_-|hypothetical-protein
MVSSFVTASLVIAGAAESEAYAAKPAKLAIESAQPVNASTVKEYIVKGKGLKGAKIKIVITDGKASVTHYTVVQKSGSFEAPVNVSTLRDGTLTVSVTQIIKGQKHSRVQKKIIKDTKAPSVPVITNKGWINAKQQNAYAVQGTAEPHSAVKVSLSDGKQRITKMVHADGKGRFRAVIDARKLAEGEITVSAVSVDSAGNQSGQSKKVLRKDVSIEAPELLNEGYINAFNYEAYPVTGTGTPGEKVVVEAADGKKSVSASGLVDEDGNYEVEINTSSLKDGKITIRVKTIDQAGNESRMASVVLIKSLTSPAKPSIENKGYVNASADATAYEVTGKGEPGAEVEVTLSDGTNEISTVGTVEENGRYRVEADISPLSDGLITITAVQTSATGNVSPEATTTVWKDTAVAAPSLNALPAVTNQNQAAYTIAGTAESNASVQIIITDGQKSLVERTSADSNGNFSKTIDLSAFNNGQLMIIVTQEDKAQNHSEATTATVTKGQ
>NC_016593.1|WP_011232356.1|2993241_2993796_-|GNAT-family-N-acetyltransferase
MGNIQPRRLVTASGQPIVIRTAWPEDAERVVAFVKAVAAEAPYLLTTEAEVVTTSERQKQWLQQIMDDPGKLAIVAEQEGDIIGFLDFHNGNKQRTKHQGSFGMSVKKDFRDQGIGTALLAALLDWAKENPLIEKVCLEVVADNTNAIRLYQKFGFVEEGVKKKAAKIDDGTYWDLILMARFVK
>NC_016593.1|WP_023633412.1|2992944_2993232_-|hypothetical-protein
MSAGRSLDEHFLPFYCAGLHFGAAAGVTRRENVSDKGMRLLPLGVRLMKPQREQYKRMAACERKTAMLVLVEMPNLLSFGPDVLLFLPLLLLEDL
>NC_016593.1|WP_014196619.1|2991980_2992607_+|LysE-family-translocator
MGIGTIFSFFGVAVLLTLAPGPDILFVIAQSLSQGKQAGIATALGLCTGLLVHISAATLGVSAVIYQSALAFAIVKYAGAAYLLYLAWQAFRKKDSSLAFGRQKPMAYASLYKKGIVMNVLNPKVSLFFLALLPQFVDPSEGRVPQQMLLLGAVFLAQALAVFTLVSIGAEKLRHLLLSNKRIAKRINRLKGALFALIGIQIAFSERS
>NC_016593.1|WP_011232353.1|2990897_2991848_+|cation-transporter
MAPTLYDFHHLPHVKTQNESKKALWVTLLLTMFFTAVEIIGGLISNSLALLSDSAHMASDVLALGLSMVALYMATRPPNRRFTFGFLRFEIITSFLNGLTLAVIALWILWEGIQRFLHPEPINFRLMLGIAAIGLVVNLTLTIVLSRSTKEEDNLNVQSALWHFIGDLISSIGVIVSALLIYFTGWTVFDPIISLVIAAIIFTGGAKIMRESYLILMEAVPDGFDLEQIRADIRKIEGVEDVHDMHLWAISTDHYSLSAHVFVNERIQPLCVILAVNEMLKEKYGIEHATIQVEHAMLHDHGRYGRAFLEKKAFHE
>NC_016593.1|WP_033007344.1|2988678_2990721_-|1,4-alpha-glucan-branching-enzyme
MYGHHFASERMRSSLIAANPTDLEVYLFHEGRLYQSYELFGAHVIRGGGAVGTRFCVWAPHAREVRLVGSFNDWNGANSSLTKVNDEGVWTIVVPENLEGHLYKYEIITPDGRVLLKADPYAFYSELRPHTASIVYDLKGYEWNDSSWQRKKRRKRIYDQPMVIYELHFGSWKKKPDGRFYTYREMADELIPYVLERGFTHIELLPLVEHPLDRSWGYQGTGYYSVTSRYGTPHDFMYFVDRCHQAGLGVIIDWVPGHFCKDAHGLYMFDGAPTYEYANEKDRENYVWGTANFDLGKPEVRSFLISNALFWLEYYHVDGFRVDAVANMLYWPNNDRLYENPYAVEFLRQLNEAVFAYDPNVWMIAEDSTDWPRVTAPTYDGGLGFNYKWNMGWMNDMLKYMETPPHERKYAHNQVSFSLLYAYSENFILPFSHDEVVHGKKSLLNKMPGSYEEKFAQLRLLYGYMMAHPGKKLLFMGSEFAQFDEWKFAEELDWVLFDFELHRKMDEYVKQLIACYKRYKPFYELDHDPRGFEWIDVHNAEQSIFSFIRRGKKEGDVLVIVCNFTNQAYDDYKVGVPLLAPYREVLNSDAAEFGGSGHVNGKRLPAFSEPFHGKPYHVRMTIPPFGISILRPVQKRGERKQNEEEVHRHVIGRRARKPASLADEKHRETSRAVWGEVPDH
>NC_016593.1|WP_025038910.1|2987627_2988797_-|glucose-1-phosphate-adenylyltransferase
MKKKCIAMLLAGGQGSRLRSLTKNIAKPAVPFGGKYRIIDFTLSNCTNSGIDTVGVLTQYQPLLLHSYIGIGSAWDLDRRNGGVTVLPPYSASSGVKWYEGTANAIYQNMNYIEQYDPDYVLVLSGDHIYKMDYQQMLDYHIAKQADATISVIEVPWEEASRFGIMNTNENMEIVEFAEKPANPKSNLASMGIYIFNWPLLREYLQIDNADPHSSHDFGKDVIPRLLRENKRLVAYPFKGYWKDVGTVKSLWEANMDLLDEHNELDLFDRSWRIYSVNPNQPPQYIAPEAEVSDSLINEGCVVEGTVERSVLFQGVCIGKGAVVKESVIMPGATVGEGAYVERAIVTPEIVIPPHSTVSPGDADDDVVLVTTEWIKQRNKDTARKDGAQ
>NC_016593.1|WP_014196625.1|3000070_3000532_-|DUF3221-domain-containing-protein
MAGCSGQTDRYAIEGYVVRKEGGSILVVSSDPQDFRSTGGLKEFYNAILVSSAPARVNIGQKVQVWIDGGIAESYPGQGKAGKVLVVPSSPRDGASLSEEEAIRQALKQEESRLEHMIPVIRAVHYDKQADTWMIQIKDAHERTEFDVRIKDE
>NC_016593.1|WP_012749415.1|3000977_3002258_-|IS110-family-transposase
MNCTQNYKIDQVTEQTLVVGIDIAKRTHYACFVDDRGRVLRKSFPIFQSKEGFRQLYEAIQEAMQAFGKPQVIVAVEPTGHYWLNLAYFLEEHGIPLVMVNPAHVCRSKELDDNLPTKHDAKDALVIARLAKDGRFLVPRLLHEIEADLRVGSTLKEKLRKEQTAVKNAIVRWTDRYFPEFWTVFRDLGKTALSVLEWTPLPADMAGRTVEELLEVYRQSEGMKCPQKAKIQALINTAKDSIGVTEGTAMARFEIAALVRRYRQLEAEIAALDAELKALVQTTMEYQWLKTVDGLGDATIIDLLAEIGSFAHYRDPRQLVKLAGLTLKENSSGQRKGQKHISKRGRKRLRSVLFRAMIPLIRHNEAFRELHEYYTTRSVNPLTGKQSIVALCRKLLNVLFAICTKKQAFDAERMKQDVLSQVQRAA
>NC_016593.1|WP_014196627.1|3002639_3004004_+|ISLre2-family-transposase
MKHLTTEWPLLKELEEQLVRTLQKVFAVLLAALLEEIDQQLAEARDKRRYQLKDKRPTTIQTLFGEVTFRRNYYYDRQAGAYTFLLDAELGFDGAQSISPCLEETAVELAVECSSYRKAARTLESIVGYAVLSHEAIRQLVLEAPVSLHHPVSKRHGRVLFVEADGLFISRQGKGKRAKEEKILAIHEGWKRNGSQLELVNRRHYLHEGEGDVWERFEEWLMNEYAYDPCRDLLIINGDAASWITACREYFGKRACFQLDRFHVARELRQCLSGHSRWREVRKKLAKQDEEGLLVELNSAVGTLEDEAKEKQMAAMIRRIESMPGCIRDYREWLSEQGVETTGMRPMGHAESVMSRFAHRVKSRRSWKDQGLRAFLRAMAARIDGIGWRKGRWEEQEPQSAVSASTKSKRIEQAKRKAGRLWADVVRQNLPCLQRSSGTPIHQALSALRDGGWV
>NC_016593.1|WP_014196629.1|3011886_3012099_-|hypothetical-protein
MQNGKVLHVLDEKSRLPISTARGKPPSSSLHLGVAEDGTTTCFTDPGVGLEAALFGRLTVHPVALQKPSM
>NC_016593.1|WP_011232385.1|3012143_3012962_+|protein-glutamine-gamma-glutamyltransferase
MIRVLSPINFDVSSSFSLPASEQRILDALVSSPKLYTYANKHQLRFEIALRDRIVRAAGELAKSRARFAIFRFSRCNSDFWTRDERGGFRLRPDVTASEAIQDIFVHSERYAFECATAIVIVFYKAVLDVIDPAAFNRLFADLLLYDWHTDRDLGIQTKKDEHFLPGDCLYFKNPEFDPLTPQWQGENAIYLGDGFFYGHGIGIQTKEGIIAALNRKRKRGATKSAYLLPDITQVDFAYLSQFARGFDEFRLPIRRSSFIFGTLGSAAFLHR
>NC_016593.1|WP_014196630.1|3012932_3013841_-|DMT-family-transporter
MKPPSTAKAYAALFIGALAVSTSAIFVKWSQAPSAVIAFYRLFLAVAIMTPLFLRHRSELRGVSRRDWLFSLCSGVLLAFHFILWFESLDYTSVASSVVLVTLQPLFAFAGGALFFRERLTVGAVGSAVLAMIGSILISWGDFRVSGEALYGDGLALLACAFVTAYWLFGQEVRQRLSLMTYTYIVYSISAAVLWLYAMLFRLSLTAYQLTDWLCFLALAVIPTLLGHSVMNWAVKWVSASTVSMAILFEPIGASALAYWLFGEPIRPFQWIGGIFILTGIALYLWEKNEKGPLTVQERSGP
>NC_016593.1|WP_011232387.1|3013967_3014645_+|MgtC/SapB-family-protein
MMFDPFLKLGISAILGLIIGLERELKRKPVGLKTCLVISISSCLLTIVSIESAYVFPLKDHITMDPLRLAAQIVSGVGFLGAGVILRRGNDSITGLTTAAIIWGAAGIGVAVGAGFYWESAFGVALLIVSVELIPFLINFFGPKQLREKEVLLQITVADAKNITKVIDHLKQQDINIKTMRIKDVEENEHLLKLRAVIDQKRSTAELYYVIRSIDDVVHVDIESG
>NC_016593.1|WP_014196631.1|3015021_3016323_-|DnaD-domain-protein
MSNLLFDDQPLVILPQLALAIGLNESIVVQQLHYWLKKSENVHDGYKWVYNTYADWQRQFPFWSESTIRRIILKLEKMGIIVAANFNRSKIDKTKWYRIDYDKLAEITKEISEMSDGQHGQAADDGVMTAHNGVSIVQGAVSFTQNGVSFVHDEGLTTHDGDSIVQDGISAVQGGASVVQGGMLTAQDGILTVQNRVLPTEDGGSMRQSSVSTIQQDQISAVYDGVSIGQNEQTMGETVRPFAQNEPSSWSNWAVEVLNLTRPIPETTTEMTSEIKREDEEDARVRTYKEIVRFCEENGFGVIGDYLREKINAWVDDASEELVLEALKIAVENGAKRWVYVETILRDWTEKGYRTVDEVRAARLAFRKERMKQRSAPPSSDGGRTMRKPIRTEIVPDWLKMDYSQPEDDDFDIEQARRELEERLKKYKTNPDG
>NC_016593.1|WP_025039336.1|3016560_3017442_+|nuclease
MKRMVIFLFCFLLMFPISAFAHPGELDELGGHFRGSDCVYLLHEPTALAKQAKTKQELVQLIQTYNGNERCKRHLTPERIDLDGHTLGKKEDRSTLRLGRTYPAELVECIDGDTAKFRVNGHVYTTRFLFIDTPESTIQVEPYGKEASRFTCSRLHQGNILLETDGDALFDKYQRLLAWVWVGKRLLQEDLAKAGLVEDFYDYGDYKYEARVRKAYEEAKRTGAGMYGKHASGEREGAGTETRPQTGEKTAKTVHPPALENKTPLERSGRPVLYTLLGLAAAAALYWLIRRLT
>NC_016593.1|WP_013144370.1|3017654_3017906_-|hypothetical-protein
MNVMPIRLFTIQDGEGFVADAFQCPVTGNLIYKSSGTPSVIAYTDLTDEQIMRLEKYGFRRLGESPARMESGPDGIEELLPRQ

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Crispr_ID: NC_016593_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016593_5

3501395-3501491

Orphan

Consensus_repeat	Method
GTTTTCCAAAAACAGACAACGAATCGTTGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_016593_5

>merge|NC_016593|5|3501395-3501491|CRISPRCasFinder
GTTTTCCAAAAACAGACAACGAATCGTTGTGCCGCGACGTTGCCATCCAGTTCGCCGCCCATTCCGGGTTTTCCAAAGACAGACAACGAATCGTTGT

>NC_016593|5|5|3501395-3501491|CRISPRCasFinder
GTTTTCCAAAAACAGACAACGAATCGTTGT	GCCGCGACGTTGCCATCCAGTTCGCCGCCCATTCCGG
GTTTTCCAAAGACAGACAACGAATCGTTGT

Protein	Signature genes	Signature genes Name	Protein_function
NC_016593.1\|WP_014196975.1\|3511402_3511834_-\|DUF1934-domain-containing-protein	unknown	unknown	gnl\|CDD\|378129
NC_016593.1\|WP_011232860.1\|3500188_3501331_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173847
NC_016593.1\|WP_013146634.1\|3509483_3509651_-\|DUF1427-family-protein	unknown	unknown	gnl\|CDD\|226767
NC_016593.1\|WP_013146624.1\|3492179_3492542_-\|response-regulator	unknown	unknown	gnl\|CDD\|381105
NC_016593.1\|WP_011232859.1\|3499348_3499981_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_016593.1\|WP_011232856.1\|3493367_3494963_-\|CTP-synthase	unknown	unknown	gnl\|CDD\|235437
NC_016593.1\|WP_011232868.1\|3509725_3511399_-\|arginine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234964
NC_016593.1\|WP_011232851.1\|3488971_3490258_-\|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	unknown	unknown	gnl\|CDD\|183779
NC_016593.1\|WP_011232852.1\|3490390_3491032_-\|fructose-6-phosphate-aldolase	unknown	unknown	gnl\|CDD\|234947
NC_016593.1\|WP_011232863.1\|3504085_3504277_-\|hypothetical-protein	unknown	unknown	unknown
NC_016593.1\|WP_011232866.1\|3508163_3509354_+\|cardiolipin-synthase	unknown	unknown	gnl\|CDD\|234967
NC_016593.1\|WP_011232853.1\|3491107_3491971_-\|fructose-bisphosphate-aldolase	unknown	unknown	gnl\|CDD\|169068
NC_016593.1\|WP_011232855.1\|3492665_3493187_+\|DUF2529-domain-containing-protein	unknown	unknown	gnl\|CDD\|378487
NC_016593.1\|WP_014196973.1\|3505730_3507827_-\|4Fe-4S-dicluster-domain-containing-protein	unknown	unknown	gnl\|CDD\|223325
NC_016593.1\|WP_011232864.1\|3504395_3505574_-\|acetyl-CoA-C-acetyltransferase	unknown	unknown	gnl\|CDD\|181311
NC_016593.1\|WP_011232862.1\|3503221_3504073_-\|3-hydroxybutyryl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|180269
NC_016593.1\|WP_011232870.1\|3512088_3512466_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|184703
NC_016593.1\|WP_014196972.1\|3501842_3502988_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173847
NC_016593.1\|WP_011232850.1\|3487974_3488937_-\|class-II-fructose-bisphosphatase	unknown	unknown	gnl\|CDD\|236536
NC_016593.1\|WP_014196968.1\|3496070_3499331_-\|methylmalonyl-CoA-mutase-family-protein	unknown	unknown	gnl\|CDD\|239650

Protein	Function_ID	Function_description	E-value
NC_016593.1\|WP_014196975.1\|3511402_3511834_-\|DUF1934-domain-containing-protein	gnl\|CDD\|378129	pfam09148, DUF1934, Domain of unknown function (DUF1934). Members of this family are found in a set of hypothetical bacterial proteins. Their precise function has not, as yet, been defined.	3.26962e-29
NC_016593.1\|WP_011232860.1\|3500188_3501331_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	0
NC_016593.1\|WP_013146634.1\|3509483_3509651_-\|DUF1427-family-protein	gnl\|CDD\|226767	COG4317, COG4317, Uncharacterized protein conserved in bacteria [Function unknown].	1.19027e-11
NC_016593.1\|WP_013146624.1\|3492179_3492542_-\|response-regulator	gnl\|CDD\|381105	cd17553, REC_Spo0F-like, phosphoacceptor receiver (REC) domain of Spo0F and similar domains. Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	2.82433e-66
NC_016593.1\|WP_011232859.1\|3499348_3499981_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	4.2751e-13
NC_016593.1\|WP_011232856.1\|3493367_3494963_-\|CTP-synthase	gnl\|CDD\|235437	PRK05380, pyrG, CTP synthetase; Validated.	0
NC_016593.1\|WP_011232868.1\|3509725_3511399_-\|arginine--tRNA-ligase	gnl\|CDD\|234964	PRK01611, argS, arginyl-tRNA synthetase; Reviewed.	0
NC_016593.1\|WP_011232851.1\|3488971_3490258_-\|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	gnl\|CDD\|183779	PRK12830, PRK12830, UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Reviewed.	0
NC_016593.1\|WP_011232852.1\|3490390_3491032_-\|fructose-6-phosphate-aldolase	gnl\|CDD\|234947	PRK01362, PRK01362, fructose-6-phosphate aldolase.	1.41619e-151
NC_016593.1\|WP_011232866.1\|3508163_3509354_+\|cardiolipin-synthase	gnl\|CDD\|234967	PRK01642, cls, cardiolipin synthetase; Reviewed.	8.03187e-107
NC_016593.1\|WP_011232853.1\|3491107_3491971_-\|fructose-bisphosphate-aldolase	gnl\|CDD\|169068	PRK07709, PRK07709, fructose-bisphosphate aldolase; Provisional.	0
NC_016593.1\|WP_011232855.1\|3492665_3493187_+\|DUF2529-domain-containing-protein	gnl\|CDD\|378487	pfam10740, DUF2529, Domain of unknown function (DUF2529). This domain is conserved in the Bacillales. The function is not known, but given this domains relationship to the SIS domain it may carry out a sugar isomerase reaction. Several members are annotated as being YWJG, a protein expressed downstream of pyrG, a gene encoding for cytidine triphosphate synthetase.	2.24597e-78
NC_016593.1\|WP_014196973.1\|3505730_3507827_-\|4Fe-4S-dicluster-domain-containing-protein	gnl\|CDD\|223325	COG0247, GlpC, Fe-S oxidoreductase [Energy production and conversion].	2.68821e-96
NC_016593.1\|WP_011232864.1\|3504395_3505574_-\|acetyl-CoA-C-acetyltransferase	gnl\|CDD\|181311	PRK08235, PRK08235, acetyl-CoA C-acetyltransferase.	0
NC_016593.1\|WP_011232862.1\|3503221_3504073_-\|3-hydroxybutyryl-CoA-dehydrogenase	gnl\|CDD\|180269	PRK05808, PRK05808, 3-hydroxybutyryl-CoA dehydrogenase; Validated.	0
NC_016593.1\|WP_011232870.1\|3512088_3512466_-\|hypothetical-protein	gnl\|CDD\|184703	PRK14485, PRK14485, putative bifunctional cbb3-type cytochrome c oxidase subunit I/II; Provisional.	3.83487e-09
NC_016593.1\|WP_014196972.1\|3501842_3502988_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	0
NC_016593.1\|WP_011232850.1\|3487974_3488937_-\|class-II-fructose-bisphosphatase	gnl\|CDD\|236536	PRK09479, glpX, fructose 1,6-bisphosphatase II; Reviewed.	0
NC_016593.1\|WP_014196968.1\|3496070_3499331_-\|methylmalonyl-CoA-mutase-family-protein	gnl\|CDD\|239650	cd03678, MM_CoA_mutase_1, Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, unknown subfamily 1; composed of uncharacterized bacterial proteins containing a C-terminal MCM domain. MCM catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA. The reaction proceeds via radical intermediates beginning with a substrate-induced homolytic cleavage of the Co-C bond of coenzyme B12 to produce cob(II)alamin and the deoxyadenosyl radical. MCM plays an important role in the conversion of propionyl-CoA to succinyl-CoA during the degradation of propionate for the Krebs cycle. In some bacteria, MCM is involved in the reverse metabolic reaction, the rearrangement of succinyl-CoA to methylmalonyl-CoA. Members of this subfamily also contain an N-terminal coenzyme B12 binding domain followed by a domain similar to the E. coli ArgK membrane ATPase.	0

>NC_016593.1|WP_011232860.1|3500188_3501331_-|acyl-CoA-dehydrogenase
MNFRLSEEHEMLRKMVREFAENEVAPTAAERDEEERFDRGIFNKMAELGLTGIPWPEEYGGIGSDYLAYVIAVEELSRVCASTGVTLSAHISLASWPIYKFGNEEQKQKYLRALATGEKLGAYALSEPGAGSDVASMKTRAVKDGDHYILNGSKVWITNGGEAEIYVVFAVTDPEKRHKGISAFIVEKGTPGFSFGKKEKKLGIRSSPTTELIFEDCRIPKENLLGQEGEGFKIAMMTLDGGRNGIAAQAVGIAQGALDAAVDYAKQRVQFGKPIIEQQGVAFKLADMATAIEAARLLTYQAAWLESNGLPYGKASAMAKLFAGDTAMKVTVEAVQIFGGNGYTKDYPVERFMRDAKITQIYEGTQEIQRLVISRMLTRN
>NC_016593.1|WP_011232859.1|3499348_3499981_-|TetR/AcrR-family-transcriptional-regulator
MKKREVIASVKDEKLVKKRRNEMIKGAISLFKQKGFHQTTTREIAKASGFSIGTLYEYIRKKEDVLYLVCDRIYDEVRERTEQDLGAHHGTIEGLRRAIAHYFRVVDELDDEVLVMYQEVKALSKESLPYVLNKELDMAAIFEHILRACVESGALQLSESEIRLFAHNIVVLGQMWAFRRWVLRKMYTLDEYIELQTEFLLKGIMEKQRV
>NC_016593.1|WP_014196968.1|3496070_3499331_-|methylmalonyl-CoA-mutase-family-protein
MAHIYRPKHHVRFVTASSLFDGHDASINIMRRILQASGAEVIHLGHNRSVEEIVNAAIQEDVQGIAVSSYQGGHMEFFKYMYDLLQERGASHIRIYGGGGGVIIPREIKELHEYGIARIFSPEDGRRLGLQGMINVMLEECDFPTVTTVTDELERLPSGDVQAIARLITLCEYRAEGENREAAAAAEAAIEQVKALEKRVPVLGITGTGGAGKSSLTDELVRRFLNEIPDIKIAILSVDPTKQKTGGALLGDRIRMNSINSPRVYMRSLATRHSRTELSPAIRDAISVVKAAGFDLVIIETSGIGQGDAAITEVCDVSMYVMTSEFGAPTQLEKIDMIDYADLIVINKFERKGSEDAKRQVQKQYQRSHQLFDRDVSEMPVYGTIASQFNDPGTNTLFVALVDTINKKAGTNWKTSLKTVANVEKHNVIIPNERRYYLREIAETVRSYHRRAEQQVEVARRLFQIEGAIEAAKERGEAEDVIRALETLKADYEAKLTPESKRILATWEETKAKYAAKQFVTKVRDKEIVTELTTKTLSGLDIPKVVLPKFKDYGEILRWVYKENVPGSFPYTAGVFPFKRQGEDPKRQFAGEGTPERTNRRFHYLCKEDKAKRLSTAFDSVTLYGEDPDYRPDIFGKVGESGVSVCTLDDMKKLYKGFDLCDPLTSVSMTINGPAPILLAMFMNTAIDQQVEKKEAELGRPLTPEEYEQVKEWTLQTVRGTVQADILKEDQGQNTCIFSTDFALKMMGDIQEYFIKHRVRNYYSVSISGYHIAEAGANPITQLAFTLANGFTYVEYYLSRGMHIDDFAPNLSFFFSNGLDPEYSVIGRVARRIWAIVMREKYGANERSQKLKYHIQTSGRSLHAQEIDFNDIRTTLQALLAIYDNCNSLHTNAYDEAITTPTEESVRRAMAIQLIITKEFGLTKNENPLQGSFIIEELTDLVEEAVLQEFERLNDRGGVLGAMEMQYQRGKIQDESLYYETKKHTGELPIIGVNTFLNPNPPSEDELNNIQLARATYEEKETQIRNLREFQERNKDKAGPALERLKQVATSGGNIFEELMETVKVASLGQITRALYEVGGQYRRNM
>NC_016593.1|WP_011232856.1|3493367_3494963_-|CTP-synthase
MTKYIFVTGGVVSSLGKGITAASLGRLLKNRGLNVTIQKFDPYINVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKYSNVTTGKIYSAVIRKERRGDYLGGTVQVIPHITNEIKERVFRAGRETNADVVITEIGGTVGDIESLPFLEAIRQIKSDVGRENVMYIHCTLVPYIKAAGEMKTKPTQHSVKELRSLGIQPNVIVVRTEMPMPQEMKEKIALFCDIDPKAVIEARDADTLYAVPLMLQEQKLDQIVCEHLRLNCREADMTEWKALVEKVRNLSKTTKIALVGKYVELPDAYISVVEALRHAGYAFDTDIDIQWINAEHVTRDNVADLLKDADGILVPGGFGDRGVEGKIEAIRYAREQRVPFLGICLGMQLASIEFARHVVGLSGAHSSEFDPNTPHPIIDLLPEQKDVEDLGGTLRLGLYPCKLQEGTLAYAAYGDEVIYERHRHRYEFNNQYRPIMEEHGFVFSGTSPDGRLVEVIELKDHPWFVAAQFHPEFTSRPTRPQPLFREFVRASLKE
>NC_016593.1|WP_011232855.1|3492665_3493187_+|DUF2529-domain-containing-protein
MKILTTQTIGLLQKIAADEELALEDGARLLAQAAIGDGRIWLYGIGELDAVVTAALLGPDPLPKAKRLEPTATDDWQETDRALLFARFSADPEAIRLVEQLQAHGVDAVAVAALVKDEPGLADMATVFIDSKLSRPLVPTEDGRRIGMPTIITASFIYYGLRVLLDEILAEYE
>NC_016593.1|WP_013146624.1|3492179_3492542_-|response-regulator
MGNKILIVDDQYGIRILLNEVFQREGYVTYQAANGMQALEIARKHHPDLVLLDMKIPGMDGIEILKRLKEIDPDIKVIIMTAYGELDMIQETKELGALMHFAKPFDIDDLRVAVKKYITA
>NC_016593.1|WP_011232853.1|3491107_3491971_-|fructose-bisphosphate-aldolase
MPLVSMKEMLNEALRGKYAVGQFNINNLEWTQAILAAAEEEKSPVILGVSEGAARYMSGFKTVVNMVKGLMEDMNITVPVAIHLDHGSSFEKCKAAIDAGFTSVMIDASHHPFEENVRITSQVVEYAHARGVSVEAELGIVGGQEDDVVGEGIIYADPKECEELVKRTGVDCLAPALGSVHGPYKGEPKLGFAEMEQIRDLTGVPLVLHGGTGIPTEQIQRAISLGTSKINVNTENQMAFTKVVRELLAKDPNVYDPRKIIGPGRDAIKATVIGKMREFGSSGKAAR
>NC_016593.1|WP_011232852.1|3490390_3491032_-|fructose-6-phosphate-aldolase
MKFFIDTANLEEIKHAHELGILAGVTTNPSLVAKENVSFHDRLREITSIVSGSVSAEVISTDAAGMIAEGEELAKIAPNITIKVPMTPEGLKAVKAFSEKGIQTNVTLVFTANQALLAARAGATYVSPFLGRLDDIGHNGLELISTIAEIFNIHGIETEIIAASIRHPHHVTEAALRGAHIATVPYKVLMQLFNHPLTDQGIEKFLADWNRQK
>NC_016593.1|WP_011232851.1|3488971_3490258_-|UDP-N-acetylglucosamine-1-carboxyvinyltransferase
MDKMKIIGGDRLRGTIKVSGAKNSAVALIPAAILADSPVTIEGLPDISDVHILGSLIEEIGGSFSFDGKEAVIDPTNMVSMPLPNGKVKKLRASYYLMGAMLGRFKRAVVGLPGGCHLGPRPIDQHIKGFEALGATVTNEQGAIYLRAEELRGARIFLDVVSVGATINIMLAAVRAKGRTIIENAAKEPEIIDVATLLSNMGAKIKGAGTDVIRIDGVEKLSGCRHAIIPDRIEAGTYMIAAAATNGEVVVDNVIPQHVESLTAKLREMGVRVETGEDQILVCGTDVLKAVDVKTLVYPGFPTDLQQPFTALLTKANGTSVVTDTIYSARFKHVDELRRMNANVKVEGRSAIVTGPVKLQGAKVKASDLRAGAALVIAGLMAEGVTEITGVEHIDRGYSNLVEKLSDIGATIWREKMTDEEIEQVKNA
>NC_016593.1|WP_011232850.1|3487974_3488937_-|class-II-fructose-bisphosphatase
MERSLSMELVRVTEAAALAAARWMGRGKKNEADDAATSAMRDVFDTVPMKGTVVIGEGEMDEAPMLYIGEKLGNGYGPRVDVAVDPLEGTNIVASGGWNALAVVAVADHGHLLHAPDMYMEKIAVGPEAVGMIDIEAPIIDNLKAVAKAKNKDIEDVVAVVLNRPRHERLIHELREAGARIKLINDGDVAAAINTAFDHTGVDILFGSGGAPEGVLAAVALKCLGGELQGKLLPQNDDEVERCKQMGIDVNKVLRMDDLVKGDDAIFAATGVTDGELLRGVRLKGAYGLTHSVVMRAKSGTVRFIEGRHSLKKKPNLVIK
>NC_016593.1|WP_014196972.1|3501842_3502988_-|acyl-CoA-dehydrogenase
MEFRFTEEQEMMRQMVREFAAAEIAPFVERMEQGEFPRPILAKMAELGLMGITVPEQYGGAGMDFVSYIIAIHEISKVSPTVGVILSVHTSVGTNPILYFGTEEQKQKYVTKLARGEYLGAFCLTEPSAGSDAKSLKTKAVRRGDRYVLNGSKIFITNGGEADTYIVFARTNPEEAGSRGISAFIVEKGTPGMSIGKDEKKMGLHGSRTVTITFEDAEVPAENLLGQEGEGFKIAMANLDVGRIGIAAQALGIAEAAVEHAVAYAKERVQFGKPIIEQQGVAFKLADMATAAEAAKWLVYRAAWLRAQGLPCGKEASMAKLFASQTAMDNAIEAVQIFGGNGYTKDYPVERLFRDAKITQIYEGTSEIQRIVISKHLCQAC
>NC_016593.1|WP_011232862.1|3503221_3504073_-|3-hydroxybutyryl-CoA-dehydrogenase
MDVKTIMVVGAGQMGSGIAQVCAVAGYQVFLYDISEAQLDKGIANIEKGLARQVEKGKMTAVDKDAALARLARSTDLHAAAEADLVIEAVVENMDVKTKLFAELDALARPETILASNTSSLPITEIAAATKRPEKVIGMHFMNPVPVMKLVEIIRGLATADDVYETIEAVARKLGKVPVEVNDFPGFISNRVLMPMINEAIYALYEGVATKEAIDEVMKLGMNHPMGPLTLADFIGLDTCLYIMETLHEGFGDDKYRPCPLLRKYVKAGWLGRKTGRGFYTYE
>NC_016593.1|WP_011232863.1|3504085_3504277_-|hypothetical-protein
MVRHAAAVSAATCGTLLIAATAAVSTVDSRGCCDDDAKTGCRWLLAAVRHMSLSAEQETQSGR
>NC_016593.1|WP_011232864.1|3504395_3505574_-|acetyl-CoA-C-acetyltransferase
MGKTVIVSGARTPFGKLGGSLQALSASELGGIAVKEALARADVSVEQVDHVILGTVLQGGQGQLPSRQAMRHAGIPWHVRTETVNKVCASGMRAVTLADQLIRLGDADVVVAGGMESMSNAPYVLPKARWGLRMGDSTVKDLMVYDGLTCSFTGVHMGVYGGNTARELGITREAQDEWAYRSHMRAIAAIEAGRLAEEIVPVTIPQRKGEPLVVEHDEAPRKDTSLEALAKLPPVFDPEGTITAGNAPGVNDGAAALVLMSEERAAREGLEPLATVVAHTAIAVEAKDFPKTPGLVINELLRKTGKTVDDIALFEINEAFAAVALAAIQIAGLDPEKVNVNGGAVALGHPIGASGARIILTLIYELKRRGGGLGIAAICSGGGQGDAILVEV
>NC_016593.1|WP_014196973.1|3505730_3507827_-|4Fe-4S-dicluster-domain-containing-protein
MNALLVVNWLAFLLVTAYAIYLFAYVVKTRAMYIKLGKKFEFDHKVKERLRNIWVNVFGQKKLLKDKKSGLIHVVFFYGFILVQFGAIDFIIKGLAPGAHLPLGPLYAGFTFFQEIVTLLILIAVLAAFYRRYIEKLVRLKRDLKAGLVLIFIAGLMLSVLFGNGMSIIWHGEEATWSEPVASLIAAAFSWVGETGAAVLFFIAWWVHLLILLTFLVYVPQSKHAHLIAAPINVFFSRLTRPKLAPIHFEDESQESFGVGKIEDFTQKQLIDLYACVECGRCTSMCPATGTGKMLSPMDLILKLRDHLTEKGAVVTSRTPWVPAFAFKHTRGNQLAFAAASEQAATIEMPSLIGDVITEEEIWACTTCRNCEDQCPVMNEHVDKIIDLRRYLVLTEGRMNPDAQRAMTNIERQGNPWGLNRKERENWRELRDDVHVPTVKEAAKAGEEIEYLFWVGSMGSYDSRSQKIALAFAKLLNEAGVKFAILGNKEKNSGDTPRRLGNEFLFQELATNNIAEFEKAGVKKIVTIDPHAYNTFKNEYPDFGFEAEVYHHTELLAKLIEEGRLVPKHPVNERITFHDSCYLGRYNDVYDAPRKILRAIPGVELVEMERNRERAMCCGAGGGLMWMEETTGNRINVARTEQALAVNPTVISSGCPYCLTMLSDGTKAKEVEDRVFTYDVAEILAKSVFGEEKEEAAS
>NC_016593.1|WP_011232866.1|3508163_3509354_+|cardiolipin-synthase
MVVISVIAIVLLLVYLDDKLGQFIFRNGRKKVVYPERRSDISLYINGRHLFSDYFAELGRARDHIHVLFYIIKNDETSAPFFQILKEKAAAGVKVRVLTDWIGSFGLPKALIRSLEESGVEFAYARKPRFPFFIYRLNRRNHRKITVIDGRVGYIGGFNIGREYNGKDANFGEWRDYHLKVNGEGVHDLQEQFLHDWEEATGRTVPDKHRYFPPLSAGAIRHQLVATNGAALEEQFIEVIRQAKKEIMIGSPYFIPSRPLFNELMQALRRGVRVTVLVPLKADHLFVKEAAYPYFYRLLKAGARIYRFYQGFYHAKTLVIDEEWCDVGTANFDRRSLFLNSEINCYVFDRAFTRLVKRAIERDLLRAEPLTVDFWQKRSLLDRGKQSISQLISAWL
>NC_016593.1|WP_013146634.1|3509483_3509651_-|DUF1427-family-protein
MKEVVLSLITGIVVGFLFTLLRLPIPAPPALAGIAGIVGVYLGMRLFQWFTVFWK
>NC_016593.1|WP_011232868.1|3509725_3511399_-|arginine--tRNA-ligase
MNIVGQIKEKMKEEIRQAAVRAGLASADELPDVLLEVPRDKAHGDYSTNIAMQLARIAKKPPRAIAEAIVGQLDRERMSVARIEIAGPGFINFYMDNRYLTAVVPAILQAGQAYGESNVGNGEKVQVEFVSANPTGDLHLGHARGAAVGDSLCNILAKAGFDVTREYYINDAGKQIYNLAKSVEARYFQALGVDMPLPEDGYYGDDIVEIGKKLAEEYGDRFVEMEEEERLAFFRDYGLRYELEKIKKDLADFRVPFDVWYSETSLYESGKIDEALSTLRERGYIYEQDGATWFRSTAFGDDKDRVLIKQDGTYTYLLPDIAYHQDKLRRGFKKLINIWGADHHGYIPRMKAAIAALGYDPEALEVEIIQMVNLYQNGERVKMSKRTGKAVTMRELMEEVGVDAVRYFFAMRSGDTHLDFDMDLAVSQSNENPVYYVQYAHARVSSILRQAEEQHISYDGDLALHHLVETEKEIELLKVLGDFPDVVAEAALKRMPHRVTAYAFDLASALHSFYNAEKVLDLDNIEKTKARLALVKAVQITLQNALALIGVSAPEQM
>NC_016593.1|WP_014196975.1|3511402_3511834_-|DUF1934-domain-containing-protein
MKETNGIPARLRQVAVIRDGPRQETVVLEADGTYYIKGETVYLQFAEENELGRVNNIVKIAPDEVTILRSGAVEMRQTFRRRQETPGHYGTAFGRWALAAKTSSMEFHYDEQRKKGRLFLSYELMLGDERSGRHTLTLTFKGV
>NC_016593.1|WP_011232870.1|3512088_3512466_-|hypothetical-protein
MKMGVKLIKISVVYFVIGVCMGLGMSMTHSFALTPVHVHINLLGWTALTLAGIIYHLFPQAAATKWAKVHFWLHNIGLPVMMIGLIFVVYGNEAFVPVTAIGGVLVVIGVILFAINVLKNVRASS

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_016593_5	5.1\|3501425\|37\|NC_016593\|CRISPRCasFinder	3501425-3501461	37	NC_016593.1	1853585-1853621	0	1.0

1. spacer 5.1|3501425|37|NC_016593|CRISPRCasFinder matches to position: 1853585-1853621, mismatch: 0, identity: 1.0

gccgcgacgttgccatccagttcgccgcccattccgg	CRISPR spacer
gccgcgacgttgccatccagttcgccgcccattccgg	Protospacer
*************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_016593_1	1.19\|396224\|35\|NC_016593\|PILER-CR,CRISPRCasFinder,CRT	396224-396258	35	NC_019544	Deep-sea thermophilic phage D6E, complete genome	26315-26349	0	1.0
NC_016593_1	1.29\|396892\|35\|NC_016593\|PILER-CR,CRISPRCasFinder,CRT	396892-396926	35	NC_019544	Deep-sea thermophilic phage D6E, complete genome	43828-43862	0	1.0
NC_016593_1	1.42\|397765\|38\|NC_016593\|PILER-CR,CRISPRCasFinder,CRT	397765-397802	38	NC_008376	Geobacillus phage GBSV1, complete genome	12453-12490	0	1.0
NC_016593_3	3.6\|2065302\|37\|NC_016593\|CRISPRCasFinder,CRT,PILER-CR	2065302-2065338	37	NZ_CP025075	[Bacillus] caldolyticus strain NEB414 plasmid pBcl1, complete sequence	12381-12417	0	1.0
NC_016593_2	2.1\|1129858\|34\|NC_016593\|CRISPRCasFinder	1129858-1129891	34	NZ_AP022559	Geobacillus subterraneus strain E55-1 plasmid pGspE55-2, complete sequence	29918-29951	1	0.971
NC_016593_3	3.6\|2065302\|37\|NC_016593\|CRISPRCasFinder,CRT,PILER-CR	2065302-2065338	37	NC_014916	Geobacillus sp. Y412MC52 plasmid pGYMC5201, complete sequence	6072-6108	1	0.973
NC_016593_3	3.6\|2065302\|37\|NC_016593\|CRISPRCasFinder,CRT,PILER-CR	2065302-2065338	37	NC_013412	Geobacillus sp. Y412MC61, complete sequence	25567-25603	1	0.973
NC_016593_1	1.6\|395355\|39\|NC_016593\|PILER-CR,CRISPRCasFinder,CRT	395355-395393	39	NZ_AP022559	Geobacillus subterraneus strain E55-1 plasmid pGspE55-2, complete sequence	29593-29631	2	0.949
NC_016593_1	1.35\|397294\|35\|NC_016593\|PILER-CR,CRISPRCasFinder,CRT	397294-397328	35	NC_029073	Geobacillus virus E3, complete genome	131869-131903	2	0.943
NC_016593_3	3.7\|2065369\|36\|NC_016593\|CRISPRCasFinder,CRT,PILER-CR	2065369-2065404	36	NZ_CP025075	[Bacillus] caldolyticus strain NEB414 plasmid pBcl1, complete sequence	15038-15073	2	0.944
NC_016593_3	3.7\|2065369\|36\|NC_016593\|CRISPRCasFinder,CRT,PILER-CR	2065369-2065404	36	NC_013412	Geobacillus sp. Y412MC61, complete sequence	28224-28259	2	0.944
NC_016593_3	3.7\|2065369\|36\|NC_016593\|CRISPRCasFinder,CRT,PILER-CR	2065369-2065404	36	NC_014916	Geobacillus sp. Y412MC52 plasmid pGYMC5201, complete sequence	3416-3451	2	0.944
NC_016593_1	1.38\|397498\|34\|NC_016593\|PILER-CR,CRISPRCasFinder,CRT	397498-397531	34	MN434092	Klebsiella phage AmPh_EK29, complete genome	129453-129486	10	0.706

1. spacer 1.19|396224|35|NC_016593|PILER-CR,CRISPRCasFinder,CRT matches to NC_019544 (Deep-sea thermophilic phage D6E, complete genome) position: , mismatch: 0, identity: 1.0

tgcaccaaaatagacctggcgatgacgctaaggaa	CRISPR spacer
tgcaccaaaatagacctggcgatgacgctaaggaa	Protospacer
***********************************

2. spacer 1.29|396892|35|NC_016593|PILER-CR,CRISPRCasFinder,CRT matches to NC_019544 (Deep-sea thermophilic phage D6E, complete genome) position: , mismatch: 0, identity: 1.0

caatctcaaaaactcggttgcgatcatcgagcgat	CRISPR spacer
caatctcaaaaactcggttgcgatcatcgagcgat	Protospacer
***********************************

3. spacer 1.42|397765|38|NC_016593|PILER-CR,CRISPRCasFinder,CRT matches to NC_008376 (Geobacillus phage GBSV1, complete genome) position: , mismatch: 0, identity: 1.0

aagatattgcgatcaacgaggcggtcgaactggataag	CRISPR spacer
aagatattgcgatcaacgaggcggtcgaactggataag	Protospacer
**************************************

4. spacer 3.6|2065302|37|NC_016593|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP025075 ([Bacillus] caldolyticus strain NEB414 plasmid pBcl1, complete sequence) position: , mismatch: 0, identity: 1.0

gattaataggctcggcattttcaggcaattggccttg	CRISPR spacer
gattaataggctcggcattttcaggcaattggccttg	Protospacer
*************************************

5. spacer 2.1|1129858|34|NC_016593|CRISPRCasFinder matches to NZ_AP022559 (Geobacillus subterraneus strain E55-1 plasmid pGspE55-2, complete sequence) position: , mismatch: 1, identity: 0.971

attgcggaaatgagagtgaaaacaaggaaaattc	CRISPR spacer
attgcggaaatgagagcgaaaacaaggaaaattc	Protospacer
****************.*****************

6. spacer 3.6|2065302|37|NC_016593|CRISPRCasFinder,CRT,PILER-CR matches to NC_014916 (Geobacillus sp. Y412MC52 plasmid pGYMC5201, complete sequence) position: , mismatch: 1, identity: 0.973

gattaataggctcggcattttcaggcaattggccttg	CRISPR spacer
gattaataggctcggcatttttaggcaattggccttg	Protospacer
*********************.***************

7. spacer 3.6|2065302|37|NC_016593|CRISPRCasFinder,CRT,PILER-CR matches to NC_013412 (Geobacillus sp. Y412MC61, complete sequence) position: , mismatch: 1, identity: 0.973

gattaataggctcggcattttcaggcaattggccttg	CRISPR spacer
gattaataggctcggcatttttaggcaattggccttg	Protospacer
*********************.***************

8. spacer 1.6|395355|39|NC_016593|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP022559 (Geobacillus subterraneus strain E55-1 plasmid pGspE55-2, complete sequence) position: , mismatch: 2, identity: 0.949

caacaaagagtccgacgacgatacgcttgagatcatcgt	CRISPR spacer
caacaaagagtcagacgatgatacgcttgagatcatcgt	Protospacer
************ *****.********************

9. spacer 1.35|397294|35|NC_016593|PILER-CR,CRISPRCasFinder,CRT matches to NC_029073 (Geobacillus virus E3, complete genome) position: , mismatch: 2, identity: 0.943

taagcgtctgtcaatgtttcttgacgttcgctttc	CRISPR spacer
taagcgtctgtcagtgtttctagacgttcgctttc	Protospacer
*************.******* *************

10. spacer 3.7|2065369|36|NC_016593|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP025075 ([Bacillus] caldolyticus strain NEB414 plasmid pBcl1, complete sequence) position: , mismatch: 2, identity: 0.944

agtaagcggccaagtggaaagggttttcgccctaga	CRISPR spacer
agtgagcggccaagtggaaagggttttcaccctaga	Protospacer
***.************************.*******

11. spacer 3.7|2065369|36|NC_016593|CRISPRCasFinder,CRT,PILER-CR matches to NC_013412 (Geobacillus sp. Y412MC61, complete sequence) position: , mismatch: 2, identity: 0.944

agtaagcggccaagtggaaagggttttcgccctaga	CRISPR spacer
agtgagcggccaagtggaaagggttttcaccctaga	Protospacer
***.************************.*******

12. spacer 3.7|2065369|36|NC_016593|CRISPRCasFinder,CRT,PILER-CR matches to NC_014916 (Geobacillus sp. Y412MC52 plasmid pGYMC5201, complete sequence) position: , mismatch: 2, identity: 0.944

agtaagcggccaagtggaaagggttttcgccctaga	CRISPR spacer
agtgagcggccaagtggaaagggttttcaccctaga	Protospacer
***.************************.*******

13. spacer 1.38|397498|34|NC_016593|PILER-CR,CRISPRCasFinder,CRT matches to MN434092 (Klebsiella phage AmPh_EK29, complete genome) position: , mismatch: 10, identity: 0.706

tgaaaatcagcagatattgcaaaagctcgaggaa	CRISPR spacer
gaaaaatcagaagatattgcagaagctaaattcc	Protospacer
 .******** **********.***** .*

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

238683 : 435899

172

Thermus_phage(56.04%)

capsid,plate,terminase,protease,head,tail,holin,integrase,tRNA,portal,transposase

attL 253441:253476|attR 319653:319688

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014194682.1\|238683_239301_-\|protease	rhomboid family intramembrane serine protease	NA	NA	NA	NA
WP_011229738.1\|239414_239804_+	holo-ACP synthase	NA	NA	NA	NA
WP_014194683.1\|239883_240897_+	outer membrane lipoprotein carrier protein LolA	NA	NA	NA	NA
WP_011229741.1\|241145_242300_+	alanine racemase	NA	NA	NA	NA
WP_011229742.1\|242426_242708_+	hypothetical protein	NA	NA	NA	NA
WP_003253417.1\|242712_243063_+	type II toxin-antitoxin system endoribonuclease NdoA	A0A2P0ZKX3	Lactobacillus_phage	2.0e-14	38.6
WP_014194685.1\|243394_245560_+	RNA-binding transcriptional accessory protein	NA	NA	NA	NA
WP_013144046.1\|245578_245692_-	cortex morphogenetic protein CmpA	NA	NA	NA	NA
WP_013144047.1\|245781_246231_+	SprT family protein	U5J9G1	Bacillus_phage	4.9e-05	26.6
253441:253476	attL	NA	NA	NA	NA
WP_011229745.1\|253959_254418_+\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE	NA	NA	NA	NA
WP_011229746.1\|254414_255155_+\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB	NA	NA	NA	NA
WP_011229747.1\|255114_255567_+	ribosomal-protein-alanine N-acetyltransferase	NA	NA	NA	NA
WP_013144049.1\|255563_256577_+\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD	A0A0R6PI74	Moraxella_phage	2.3e-66	43.6
WP_014194690.1\|256898_258824_-	ABC-F family ATP-binding cassette domain-containing protein	A0A2K9L3Z8	Tupanvirus	5.8e-63	34.3
WP_011229750.1\|258920_259409_+	cyclic pyranopterin monophosphate synthase MoaC	NA	NA	NA	NA
WP_013144051.1\|259424_260066_+	redox-sensing transcriptional repressor Rex	NA	NA	NA	NA
WP_013144052.1\|260083_260236_+	twin-arginine translocase TatA/TatE family subunit	NA	NA	NA	NA
WP_014194692.1\|260256_261000_+	twin-arginine translocase subunit TatC	NA	NA	NA	NA
WP_075261519.1\|261015_261195_+	hypothetical protein	NA	NA	NA	NA
WP_013522803.1\|261183_261363_-	YdiK family protein	NA	NA	NA	NA
WP_011229755.1\|261359_262094_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_013144057.1\|262450_262735_+	co-chaperone GroES	A0A221S3C8	uncultured_virus	1.1e-18	50.5
WP_011229758.1\|262839_264456_+	chaperonin GroEL	A0A219YK78	uncultured_virus	1.3e-164	59.0
WP_013144059.1\|264533_265718_-\|integrase	site-specific integrase	S6C485	Thermus_phage	1.9e-226	100.0
WP_014194694.1\|266067_266289_+	hypothetical protein	S6AVX7	Thermus_phage	1.7e-35	100.0
WP_014194695.1\|266280_267132_-	TIR domain-containing protein	S6BFN8	Thermus_phage	7.5e-140	100.0
WP_014194696.1\|267132_267573_-	ImmA/IrrE family metallo-endopeptidase	S6B1N5	Thermus_phage	2.0e-80	100.0
WP_033012578.1\|267593_268061_-	helix-turn-helix transcriptional regulator	S6C481	Thermus_phage	1.1e-79	100.0
WP_146331429.1\|268219_268498_+	helix-turn-helix domain-containing protein	S6BA02	Thermus_phage	1.1e-44	98.9
WP_033012579.1\|268469_269225_+	antirepressor	S6AVX3	Thermus_phage	1.7e-143	100.0
WP_014194701.1\|269376_269694_-	hypothetical protein	S6B1N1	Thermus_phage	1.3e-52	100.0
WP_033012596.1\|269776_270085_+	phage protein	S6C476	Thermus_phage	1.6e-52	100.0
WP_014194702.1\|270087_270363_+	hypothetical protein	S6B9Z9	Thermus_phage	5.0e-45	100.0
WP_014194703.1\|270373_270640_+	hypothetical protein	S6AVW9	Thermus_phage	2.7e-43	100.0
WP_014194704.1\|270639_270858_+	hypothetical protein	NA	NA	NA	NA
WP_033012597.1\|271022_271328_+	hypothetical protein	S6BFM8	Thermus_phage	1.5e-53	100.0
WP_014194705.1\|271324_271525_+	hypothetical protein	S6B1M6	Thermus_phage	5.8e-35	100.0
WP_014194706.1\|271634_272570_+	hypothetical protein	S6C475	Thermus_phage	5.3e-171	100.0
WP_014194708.1\|272771_273617_+	recombination protein RecT	S6AVW6	Thermus_phage	6.1e-158	100.0
WP_014194710.1\|273792_274713_+	HTH domain-containing protein	S6BFM4	Thermus_phage	2.8e-148	100.0
WP_033012580.1\|274654_275497_+	DNA replication protein	S6B1M2	Thermus_phage	2.2e-160	100.0
WP_014194713.1\|276011_276521_+	dUTPase	S6AVW3	Thermus_phage	8.9e-96	100.0
WP_020279139.1\|276510_276723_+	hypothetical protein	S6BFL9	Thermus_phage	3.4e-33	100.0
WP_033012588.1\|276970_277390_+	RusA family crossover junction endodeoxyribonuclease	S6B1L9	Thermus_phage	1.0e-73	100.0
WP_014194717.1\|277481_278150_+	hypothetical protein	S6C473	Thermus_phage	8.0e-113	99.5
WP_033012591.1\|278282_278531_+	hypothetical protein	S6B9Y8	Thermus_phage	2.5e-35	100.0
WP_014194720.1\|278609_279062_+	ArpU family transcriptional regulator	S6AVV9	Thermus_phage	9.7e-78	100.0
WP_146331435.1\|279104_280412_+	DNA-processing protein DprA	S6BFL3	Thermus_phage	6.4e-231	100.0
WP_014194722.1\|280392_281646_+	hypothetical protein	S6B1L6	Thermus_phage	3.7e-236	100.0
WP_014194724.1\|281951_282392_+\|terminase	terminase small subunit	S6B9Y6	Thermus_phage	9.8e-75	100.0
WP_146331439.1\|282378_283641_+\|terminase	PBSX family phage terminase large subunit	S6AVV7	Thermus_phage	2.2e-244	100.0
WP_014194726.1\|283654_285079_+\|portal	phage portal protein	S6BFK8	Thermus_phage	4.9e-277	100.0
WP_014194727.1\|285071_286529_+\|head	SPP1 family phage head morphogenesis protein	S6B1L4	Thermus_phage	6.6e-277	100.0
WP_014194728.1\|286525_286720_+	hypothetical protein	S6C469	Thermus_phage	1.2e-29	100.0
WP_014194729.1\|286851_287409_+	methyl-accepting chemotaxis protein	S6B9Y2	Thermus_phage	5.5e-75	100.0
WP_014194730.1\|287429_288248_+\|capsid	N4-gp56 family major capsid protein	S6AVV3	Thermus_phage	1.5e-153	100.0
WP_014194732.1\|288407_288749_+	hypothetical protein	S6B1K9	Thermus_phage	1.7e-58	100.0
WP_014194733.1\|288750_289116_+	hypothetical protein	S6C466	Thermus_phage	6.4e-64	100.0
WP_014194734.1\|289115_289514_+	HK97 gp10 family phage protein	S6B9X8	Thermus_phage	8.5e-70	100.0
WP_014194735.1\|289503_289911_+	hypothetical protein	S6AVU9	Thermus_phage	2.7e-71	100.0
WP_014194736.1\|289894_290077_+	hypothetical protein	S6BFJ9	Thermus_phage	1.4e-24	100.0
WP_014194737.1\|290076_291375_+\|tail	Sheath tail protein	S6B1K7	Thermus_phage	1.0e-244	100.0
WP_014194738.1\|291393_291858_+\|tail	phage tail tube protein	S6C462	Thermus_phage	4.8e-80	100.0
WP_014194739.1\|291869_292271_+	hypothetical protein	S6B9X5	Thermus_phage	2.3e-70	100.0
WP_075261445.1\|292270_292450_+	hypothetical protein	NA	NA	NA	NA
WP_014194740.1\|292454_294713_+	tape measure protein	S6AVU8	Thermus_phage	0.0e+00	100.0
WP_014194741.1\|294712_295384_+	LysM peptidoglycan-binding domain-containing protein	S6BFJ4	Thermus_phage	6.4e-126	100.0
WP_014194742.1\|295385_296345_+	hypothetical protein	S6B1K2	Thermus_phage	7.6e-173	100.0
WP_014194743.1\|296346_296604_+	DUF2577 domain-containing protein	S6C459	Thermus_phage	6.1e-37	100.0
WP_014194744.1\|296603_297017_+	DUF2634 domain-containing protein	S6B9X2	Thermus_phage	1.2e-69	100.0
WP_014194745.1\|297009_298050_+\|plate	baseplate J/gp47 family protein	S6AVU3	Thermus_phage	2.3e-191	100.0
WP_014194746.1\|298050_298635_+	YmfQ family protein	S6BFJ0	Thermus_phage	1.6e-109	100.0
WP_014194748.1\|300081_300456_+	hypothetical protein	S6C455	Thermus_phage	3.9e-64	100.0
WP_033012595.1\|300677_301097_+\|holin	phage holin family protein	S6AVT9	Thermus_phage	1.1e-67	100.0
WP_014194750.1\|301093_301762_+	LysM peptidoglycan-binding domain-containing protein	S6BFI4	Thermus_phage	1.0e-128	100.0
WP_014194751.1\|301885_302233_+	hypothetical protein	S6B1J4	Thermus_phage	3.6e-56	100.0
WP_014194752.1\|302613_303669_+\|transposase	IS200/IS605 family element transposase accessory protein TnpB	NA	NA	NA	NA
WP_014194754.1\|304052_304445_-	hypothetical protein	NA	NA	NA	NA
WP_014194755.1\|304564_305935_+	class II fumarate hydratase	NA	NA	NA	NA
WP_014194756.1\|306136_307087_+	MoxR family ATPase	NA	NA	NA	NA
WP_014194757.1\|307083_308265_+	DUF58 domain-containing protein	NA	NA	NA	NA
WP_014194758.1\|308261_310424_+	transglutaminase domain-containing protein	NA	NA	NA	NA
WP_011229763.1\|310627_312160_+	glutamine-hydrolyzing GMP synthase	A0A1V0SH76	Hokovirus	3.8e-17	29.5
WP_014194759.1\|312450_313776_+	NCS2 family permease	A0A0R6PHV4	Moraxella_phage	1.1e-52	32.4
WP_020279816.1\|313864_314236_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_011229765.1\|320321_320771_-	Hsp20/alpha crystallin family protein	NA	NA	NA	NA
319653:319688	attR	NA	NA	NA	NA
WP_011229766.1\|321131_321620_+	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	3.1e-21	42.9
WP_011229767.1\|321612_322761_+	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
WP_013144127.1\|322757_324053_+	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	3.8e-18	33.6
WP_014194762.1\|324113_324857_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A0E3HI61	Synechococcus_phage	9.4e-46	42.5
WP_014194763.1\|324844_325099_+	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_014194764.1\|325095_325782_+	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_014194765.1\|325765_327994_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	7.7e-168	42.1
WP_011229773.1\|327969_329382_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	8.3e-51	34.7
WP_014194766.1\|329505_330546_+	phosphoribosylformylglycinamidine cyclo-ligase	A0A0E3FC27	Synechococcus_phage	8.0e-67	43.3
WP_011229775.1\|330542_331175_+	phosphoribosylglycinamide formyltransferase	E3SNR5	Prochlorococcus_phage	4.1e-26	37.4
WP_014194767.1\|331137_332676_+	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	Q58MG4	Prochlorococcus_phage	1.3e-78	52.6
WP_014194768.1\|332699_333992_+	phosphoribosylamine--glycine ligase	NA	NA	NA	NA
WP_011229779.1\|334301_334547_-	DUF2892 domain-containing protein	NA	NA	NA	NA
WP_014194770.1\|334642_336388_+	adenine deaminase	NA	NA	NA	NA
WP_081130754.1\|336406_337435_+	DUF3048 domain-containing protein	NA	NA	NA	NA
WP_014194772.1\|337527_337863_+	hypothetical protein	NA	NA	NA	NA
WP_014194773.1\|337960_338680_+	heptaprenylglyceryl phosphate synthase	NA	NA	NA	NA
WP_025039099.1\|338708_340883_+	DNA helicase PcrA	A7KV33	Bacillus_phage	2.2e-135	42.1
WP_014194775.1\|340903_342916_+	NAD-dependent DNA ligase LigA	A0A0K2QQN8	Ralstonia_phage	1.2e-127	40.0
WP_014194776.1\|342912_344136_+	CamS family sex pheromone protein	NA	NA	NA	NA
WP_014194777.1\|344336_345191_-\|transposase	transposase	A0A1L2BWW3	Bacteriophage	3.8e-22	33.7
WP_011229787.1\|345375_345933_+	TIGR00730 family Rossman fold protein	A0A1V0S9E9	Catovirus	8.7e-12	29.4
WP_014194778.1\|346366_347143_-	VOC family protein	NA	NA	NA	NA
WP_014194779.1\|347172_347721_-	hypothetical protein	NA	NA	NA	NA
WP_014194780.1\|348343_348634_+\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	NA	NA	NA	NA
WP_011229791.1\|348646_350104_+\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA	NA	NA	NA	NA
WP_011229792.1\|350117_351548_+\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB	NA	NA	NA	NA
WP_011229793.1\|351723_353028_+	homocysteine synthase	A0A0B5JD48	Pandoravirus	4.1e-20	26.4
WP_025039125.1\|353546_354626_+\|transposase	ISL3 family transposase	NA	NA	NA	NA
WP_041470245.1\|354932_356213_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_011229796.1\|356651_357041_+	hypothetical protein	NA	NA	NA	NA
WP_011229797.1\|357158_358040_+	NADH dehydrogenase	NA	NA	NA	NA
WP_014194784.1\|358023_358764_+	hypothetical protein	NA	NA	NA	NA
WP_011229799.1\|358760_359462_+	hypothetical protein	NA	NA	NA	NA
WP_011229800.1\|359475_360129_+	heme ABC exporter ATP-binding protein CcmA	G3M9Y6	Bacillus_virus	6.2e-25	32.2
WP_011229802.1\|360542_361904_-\|transposase	IS4-like element ISGka3 family transposase	NA	NA	NA	NA
WP_089113994.1\|363581_363899_+\|transposase	transposase	NA	NA	NA	NA
WP_094239504.1\|363947_364052_+	hypothetical protein	NA	NA	NA	NA
WP_014194788.1\|364444_367585_+	lantibiotic dehydratase	A0A2H4PQG8	Staphylococcus_phage	5.7e-92	26.3
WP_014194791.1\|368690_369860_+\|transposase	IS256 family transposase	A0A0K2CZ57	Paenibacillus_phage	3.4e-26	26.7
WP_020279663.1\|371003_372311_+	lanthionine synthetase C family protein	NA	NA	NA	NA
WP_004888808.1\|372652_373351_+	response regulator transcription factor	NA	NA	NA	NA
WP_014194795.1\|373337_374756_+	HAMP domain-containing histidine kinase	Q6XM27	Feldmannia_irregularis_virus	7.4e-07	23.1
WP_014194791.1\|375046_376216_-\|transposase	IS256 family transposase	A0A0K2CZ57	Paenibacillus_phage	3.4e-26	26.7
WP_041470246.1\|376313_376739_-	NisI/SpaI family lantibiotic immunity lipoprotein	NA	NA	NA	NA
WP_004888811.1\|376793_377582_-	lantibiotic immunity ABC transporter MutG family permease subunit	NA	NA	NA	NA
WP_008881432.1\|377583_378330_-	lantibiotic immunity ABC transporter MutE/EpiE family permease subunit	NA	NA	NA	NA
WP_008881431.1\|378348_379038_-	lantibiotic protection ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	5.1e-54	48.0
WP_011229818.1\|379640_380270_-	ABC transporter permease	NA	NA	NA	NA
WP_011229819.1\|380524_381652_-\|holin	betaine/proline/choline family ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	2.5e-29	35.5
WP_014194799.1\|381668_382571_-	proline/glycine betaine ABC-type transport system, permease component fused to periplasmic component	NA	NA	NA	NA
WP_014194800.1\|383151_384810_+\|transposase	IS1634 family transposase	NA	NA	NA	NA
WP_014194801.1\|384938_385586_-	hypothetical protein	NA	NA	NA	NA
WP_014194802.1\|385730_387221_+	TIGR02677 family protein	NA	NA	NA	NA
WP_014194803.1\|387223_388420_+	TIGR02678 family protein	NA	NA	NA	NA
WP_014194804.1\|388379_392501_+	TIGR02680 family protein	NA	NA	NA	NA
WP_014194805.1\|392497_393718_+	TIGR02679 family protein	NA	NA	NA	NA
WP_014194806.1\|393860_394787_+\|transposase	transposase	NA	NA	NA	NA
WP_011229827.1\|398439_398664_-	hypothetical protein	NA	NA	NA	NA
WP_014194810.1\|400205_401438_-	MFS transporter	NA	NA	NA	NA
WP_014194812.1\|401637_402291_-	PspA/IM30 family protein	NA	NA	NA	NA
WP_014194813.1\|402250_402775_-	hypothetical protein	NA	NA	NA	NA
WP_014194816.1\|403683_405993_-	YhgE/Pip domain-containing protein	NA	NA	NA	NA
WP_014194819.1\|406645_408019_-	GHKL domain-containing protein	Q8QKV7	Ectocarpus_siliculosus_virus	5.7e-12	26.0
WP_015373859.1\|408008_408671_-	response regulator transcription factor	W8CYM9	Bacillus_phage	1.6e-33	36.5
WP_014194821.1\|408850_409276_+	PepSY domain-containing protein	NA	NA	NA	NA
WP_014194822.1\|409299_409485_+	hypothetical protein	NA	NA	NA	NA
WP_014194823.1\|409465_410671_+	PDZ domain-containing protein	W5SAB9	Pithovirus	1.0e-12	29.1
WP_014194824.1\|411094_411973_+\|transposase	IS982-like element ISGsp1 family transposase	NA	NA	NA	NA
WP_021322237.1\|412110_412836_+	distant relative of cell wall-associated hydrolase-like protein	NA	NA	NA	NA
WP_011229842.1\|414493_414883_+	DUF962 domain-containing protein	NA	NA	NA	NA
WP_011229843.1\|415019_415886_-\|transposase	transposase	NA	NA	NA	NA
WP_011229844.1\|416098_416638_+	membrane protein	NA	NA	NA	NA
WP_011229845.1\|416660_418178_+	flotillin family protein	A0A2I2L4B2	Orpheovirus	2.7e-07	27.1
WP_011229846.1\|418320_419241_+	diacylglycerol kinase	A0A1V0SBJ0	Catovirus	1.2e-26	30.9
WP_014194830.1\|419318_420692_+	23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD	A0A2K5B251	Erysipelothrix_phage	1.8e-127	49.8
WP_014194831.1\|421029_422487_+	SAM-dependent DNA methyltransferase	A0A1W6JNK1	Staphylococcus_phage	1.1e-24	27.9
WP_020279715.1\|422498_423665_+	restriction endonuclease subunit S	A0A2H4PQP5	Staphylococcus_phage	1.1e-08	28.0
WP_025039117.1\|423707_427049_+	DUF4145 domain-containing protein	A0A097BY72	Enterococcus_phage	6.8e-19	25.2
WP_011229851.1\|427307_427922_+\|transposase	Rpn family recombination-promoting nuclease/putative transposase	NA	NA	NA	NA
WP_011229852.1\|429117_429681_+\|transposase	transposase	NA	NA	NA	NA
WP_011229853.1\|429823_431071_+\|transposase	IS481 family transposase	M4T586	Rhodobacter_phage	1.3e-10	25.1
WP_011229854.1\|431063_431864_+	AAA family ATPase	NA	NA	NA	NA
WP_011229855.1\|432163_432532_+	helix-turn-helix transcriptional regulator	E4ZFI8	Streptococcus_phage	1.2e-49	77.9
WP_014194838.1\|432524_434735_+	cadmium-translocating P-type ATPase	E4ZFI9	Streptococcus_phage	0.0e+00	85.1
WP_014194839.1\|434765_435899_+\|transposase	IS4 family transposase	NA	NA	NA	NA

DBSCAN-SWA_2

578625 : 631445

Bacillus_phage(30.77%)

tRNA,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011229986.1\|578625_579768_+\|tRNA	tRNA epoxyqueuosine(34) reductase QueG	NA	NA	NA	NA
WP_011229987.1\|579829_580693_+	amidase domain-containing protein	NA	NA	NA	NA
WP_011229988.1\|580713_581187_+\|tRNA	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	NA	NA	NA	NA
WP_011229990.1\|581510_583406_+	PrkA family serine protein kinase	A0MN77	Thermus_phage	2.4e-109	38.4
WP_014194932.1\|583714_584872_+	sporulation protein YhbH	A0A140HLI1	Bacillus_phage	1.4e-24	45.3
WP_014194933.1\|584947_585640_-	hypothetical protein	NA	NA	NA	NA
WP_014194934.1\|585906_586884_+	LacI family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_011230062.1\|586942_587623_-	response regulator	W8CYM9	Bacillus_phage	4.6e-07	26.4
WP_011230063.1\|587686_589264_-	sensor histidine kinase	W8CYF6	Bacillus_phage	9.7e-08	25.6
WP_014194935.1\|589577_590618_+	TRAP transporter substrate-binding protein	NA	NA	NA	NA
WP_025039067.1\|590778_592041_+	dicarboxylate/amino acid:cation symporter	NA	NA	NA	NA
WP_011230066.1\|592323_593151_+	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	5.7e-76	52.0
WP_011230067.1\|593298_593991_+	zinc metallopeptidase	NA	NA	NA	NA
WP_011230068.1\|594102_595443_+	HlyC/CorC family transporter	NA	NA	NA	NA
WP_011230069.1\|595517_596417_-	RluA family pseudouridine synthase	NA	NA	NA	NA
WP_014194938.1\|596555_596954_+	YhcU family protein	NA	NA	NA	NA
WP_011230071.1\|597279_597753_-	thioredoxin family protein	NA	NA	NA	NA
WP_014194940.1\|597749_598187_-	disulfide bond formation protein B	NA	NA	NA	NA
WP_011230073.1\|598360_598807_+	CBS domain-containing protein	A0A2I6B2H4	Macacine_betaherpesvirus	3.0e-15	39.7
WP_014194941.1\|598923_600681_+	phospho-sugar mutase	A0A1X9I671	Streptococcus_phage	1.2e-160	49.5
WP_013146280.1\|600728_600986_-	hypothetical protein	NA	NA	NA	NA
WP_025039331.1\|601166_601415_+	hypothetical protein	NA	NA	NA	NA
WP_011230077.1\|601444_602050_-	DedA family protein	NA	NA	NA	NA
WP_014194943.1\|602209_603040_+	stage V sporulation protein R	NA	NA	NA	NA
WP_014194944.1\|603314_605186_+	ATPase AAA	NA	NA	NA	NA
WP_011230080.1\|605968_606550_+\|transposase	transposase	NA	NA	NA	NA
WP_011230081.1\|606867_607341_+	hypothetical protein	NA	NA	NA	NA
WP_012749256.1\|607477_608200_+	iron permease	NA	NA	NA	NA
WP_011230084.1\|608491_608800_+	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_011230085.1\|608814_609762_+	cation transporter	NA	NA	NA	NA
WP_011230086.1\|609787_610834_+	SidA/IucD/PvdA family monooxygenase	A0A2H4J2Q2	uncultured_Caudovirales_phage	7.6e-17	25.0
WP_011230088.1\|612734_613103_+	helix-turn-helix transcriptional regulator	E4ZFI8	Streptococcus_phage	1.8e-50	78.7
WP_011230089.1\|613095_615234_+	cadmium-translocating P-type ATPase	E4ZFI9	Streptococcus_phage	0.0e+00	84.8
WP_041470248.1\|615524_616370_+	DNA-binding protein	NA	NA	NA	NA
WP_014194949.1\|617552_619211_-\|transposase	IS1634 family transposase	NA	NA	NA	NA
WP_014194950.1\|619239_619533_+\|transposase	transposase	NA	NA	NA	NA
WP_011230091.1\|620151_620499_+	winged helix-turn-helix transcriptional regulator	A0A218MNF3	uncultured_virus	6.0e-11	36.6
WP_011230092.1\|620538_621600_+	ACR3 family arsenite efflux transporter	NA	NA	NA	NA
WP_011230093.1\|621620_622043_+	arsenate reductase (thioredoxin)	A0A2H4PQT9	Staphylococcus_phage	2.7e-42	62.9
WP_011230094.1\|622191_622638_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_011230095.1\|622829_623372_+	hypothetical protein	NA	NA	NA	NA
WP_012749415.1\|623575_624856_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_011230096.1\|625252_626047_+	arsenite methyltransferase	NA	NA	NA	NA
WP_011230097.1\|626174_626666_+	N-acetyltransferase	NA	NA	NA	NA
WP_011231214.1\|626894_627773_-\|transposase	IS982-like element ISGsp1 family transposase	NA	NA	NA	NA
WP_014194953.1\|627908_629570_-	single-stranded-DNA-specific exonuclease RecJ	A7KV88	Bacillus_phage	1.8e-65	32.9
WP_012749415.1\|630164_631445_-\|transposase	IS110 family transposase	NA	NA	NA	NA

DBSCAN-SWA_3

827601 : 874141

Bacillus_phage(25.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014195112.1\|827601_828882_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_014195113.1\|829278_829956_+	MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_014195114.1\|830214_831015_-	AAA family ATPase	NA	NA	NA	NA
WP_014195116.1\|832044_833412_+\|transposase	ISLre2 family transposase	NA	NA	NA	NA
WP_014194630.1\|834120_834678_-\|transposase	transposase family protein	NA	NA	NA	NA
WP_025039361.1\|835210_835489_+	DUF3467 domain-containing protein	NA	NA	NA	NA
WP_011232756.1\|835488_835884_+	hypothetical protein	NA	NA	NA	NA
WP_011232755.1\|835852_836110_+	DUF2283 domain-containing protein	NA	NA	NA	NA
WP_011232754.1\|836459_836912_-	N-acetyltransferase	NA	NA	NA	NA
WP_011232753.1\|837168_838935_+	DUF262 domain-containing protein	NA	NA	NA	NA
WP_011232752.1\|839008_839608_+	hypothetical protein	NA	NA	NA	NA
WP_014195121.1\|839751_840756_-	hypothetical protein	NA	NA	NA	NA
WP_011232750.1\|840926_841424_-	L,D-transpeptidase family protein	NA	NA	NA	NA
WP_011232749.1\|841657_841858_+	hypothetical protein	NA	NA	NA	NA
WP_011232748.1\|841901_842375_-	hypothetical protein	NA	NA	NA	NA
WP_013524772.1\|843599_844493_+\|transposase	Rpn family recombination-promoting nuclease/putative transposase	NA	NA	NA	NA
WP_014195125.1\|844532_845546_-	LacI family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_014195126.1\|846041_847367_+	extracellular solute-binding protein	NA	NA	NA	NA
WP_011232743.1\|847368_848247_+	sugar ABC transporter permease	NA	NA	NA	NA
WP_011232742.1\|848233_849064_+	carbohydrate ABC transporter permease	NA	NA	NA	NA
WP_014195127.1\|849105_850053_+	DUF1861 family protein	NA	NA	NA	NA
WP_011232740.1\|850055_851114_+	glycosidase	NA	NA	NA	NA
WP_011232739.1\|851395_852283_+	UTP--glucose-1-phosphate uridylyltransferase GalU	A0A127AW70	Bacillus_phage	1.1e-77	52.7
WP_011232738.1\|852325_853639_+	ATP-binding protein	NA	NA	NA	NA
WP_011232737.1\|853641_854073_+	hypothetical protein	NA	NA	NA	NA
WP_014195130.1\|854094_854472_+	DUF488 family protein	NA	NA	NA	NA
WP_014195131.1\|854475_854961_+	Appr-1-p processing protein	G3MBI4	Bacillus_virus	1.7e-43	56.1
WP_011232734.1\|855241_856213_+	DUF1861 family protein	NA	NA	NA	NA
WP_041470253.1\|856826_859589_-	DEAD/DEAH box helicase	E7DNC5	Pneumococcus_phage	5.8e-32	26.0
WP_014195136.1\|859585_861253_-	hypothetical protein	NA	NA	NA	NA
WP_014195137.1\|861445_862762_+	SEC-C domain-containing protein	NA	NA	NA	NA
WP_014195139.1\|863059_865255_+	hypothetical protein	NA	NA	NA	NA
WP_014195141.1\|865781_867116_+	hypothetical protein	NA	NA	NA	NA
WP_011232727.1\|867202_867913_-	plasmid pRiA4b ORF-3 family protein	A0A2H4PDG5	Mycobacterium_phage	6.1e-26	35.4
WP_080729647.1\|868040_868274_+	hypothetical protein	NA	NA	NA	NA
WP_049787559.1\|868683_870024_+	SH3 domain-containing protein	NA	NA	NA	NA
WP_014195145.1\|870338_871217_+\|transposase	IS982 family transposase	NA	NA	NA	NA
WP_014195146.1\|871728_872286_+	signal peptidase I	NA	NA	NA	NA
WP_014195147.1\|872482_874141_+\|transposase	IS1634 family transposase	NA	NA	NA	NA

DBSCAN-SWA_4

1060129 : 1107905

uncultured_Caudovirales_phage(18.18%)

protease,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014194800.1\|1060129_1061788_-\|transposase	IS1634 family transposase	NA	NA	NA	NA
WP_152540314.1\|1061784_1062051_-	hypothetical protein	NA	NA	NA	NA
WP_014195281.1\|1062173_1063598_-	amino acid permease	NA	NA	NA	NA
WP_021321685.1\|1064694_1066389_+	M3 family oligoendopeptidase	NA	NA	NA	NA
WP_014195285.1\|1066609_1067125_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_122983902.1\|1067196_1068468_+	DUF3533 domain-containing protein	NA	NA	NA	NA
WP_014195287.1\|1068492_1068705_+	ATP-binding cassette domain-containing protein	NA	NA	NA	NA
WP_014195289.1\|1069153_1069807_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_014195290.1\|1069834_1070254_-	DUF86 domain-containing protein	NA	NA	NA	NA
WP_014195291.1\|1070243_1070651_-	nucleotidyltransferase domain-containing protein	NA	NA	NA	NA
WP_014195292.1\|1070931_1073064_-\|protease	ATP-dependent Clp protease ATP-binding subunit	K4FB40	Cronobacter_phage	1.6e-125	41.8
WP_025039183.1\|1073331_1074078_+	FixH family protein	NA	NA	NA	NA
WP_014195294.1\|1074185_1075226_+	membrane protein	NA	NA	NA	NA
WP_014195295.1\|1075285_1076896_-	chemotaxis protein	A0A2H4J162	uncultured_Caudovirales_phage	2.1e-13	24.7
WP_014195296.1\|1077036_1078551_+	spore germination protein	NA	NA	NA	NA
WP_021322459.1\|1078562_1079648_+	Ger(x)C family spore germination protein	NA	NA	NA	NA
WP_014195298.1\|1079674_1080787_+	GerAB/ArcD/ProY family transporter	NA	NA	NA	NA
WP_031206548.1\|1080959_1081631_+	7-cyano-7-deazaguanine synthase QueC	A0A2H4J8Q7	uncultured_Caudovirales_phage	3.9e-67	57.5
WP_011230477.1\|1081627_1082065_+	6-carboxytetrahydropterin synthase QueD	A0A1U9WRB3	Streptococcus_virus	9.6e-06	33.0
WP_011230478.1\|1082064_1082799_+	7-carboxy-7-deazaguanine synthase QueE	A0A1U9WRB6	Streptococcus_virus	3.8e-55	44.6
WP_011230479.1\|1082851_1083349_+	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	E7DN65	Pneumococcus_phage	7.7e-52	67.9
WP_014195299.1\|1083402_1084086_+	NAD(P)H-binding protein	NA	NA	NA	NA
WP_013145942.1\|1084116_1084296_-	DUF2187 domain-containing protein	NA	NA	NA	NA
WP_014195301.1\|1084597_1085182_-	LysM peptidoglycan-binding domain-containing protein	U5PWL4	Bacillus_phage	1.4e-41	50.0
WP_011230483.1\|1085382_1085577_-	hypothetical protein	NA	NA	NA	NA
WP_014195302.1\|1085748_1086423_+	hypothetical protein	NA	NA	NA	NA
WP_014195303.1\|1086692_1087442_+	glucose 1-dehydrogenase	Q06VL0	Trichoplusia_ni_ascovirus	7.1e-17	31.2
WP_011230486.1\|1087507_1087753_+	hypothetical protein	NA	NA	NA	NA
WP_011230487.1\|1087808_1089101_+	PAS domain-containing protein	A0A1V0SGX0	Hokovirus	2.1e-16	26.0
WP_014195304.1\|1089420_1090569_+	cation:proton antiporter	NA	NA	NA	NA
WP_014195305.1\|1090757_1091579_-	alpha/beta hydrolase	R4JP33	Mycobacterium_phage	1.8e-05	34.6
WP_011230491.1\|1091721_1092579_+	transcription antiterminator	NA	NA	NA	NA
WP_014195306.1\|1092811_1094830_+	PTS glucose transporter subunit IIABC	NA	NA	NA	NA
WP_011230496.1\|1094936_1095203_+	phosphocarrier protein HPr	NA	NA	NA	NA
WP_014195308.1\|1095202_1096924_+	phosphoenolpyruvate--protein phosphotransferase	NA	NA	NA	NA
WP_011230498.1\|1097008_1097560_-\|protease	spore protease YyaC	NA	NA	NA	NA
WP_011230499.1\|1097640_1097832_-	hypothetical protein	NA	NA	NA	NA
WP_049787561.1\|1098223_1098808_+	hypothetical protein	NA	NA	NA	NA
WP_014194571.1\|1104882_1106247_+\|transposase	ISLre2 family transposase	NA	NA	NA	NA
WP_014195312.1\|1106847_1107375_-\|transposase	IS630 family transposase	A0A1V0SCG6	Indivirus	5.5e-08	29.1
WP_014195313.1\|1107374_1107905_-\|transposase	IS630 family transposase	NA	NA	NA	NA

DBSCAN-SWA_5

1499788 : 1572463

Bacillus_phage(28.57%)

tRNA,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014195570.1\|1499788_1501201_+\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA	NA	NA	NA	NA
WP_014195572.1\|1501453_1502326_+\|transposase	Rpn family recombination-promoting nuclease/putative transposase	NA	NA	NA	NA
WP_014195573.1\|1502569_1503061_+	hypothetical protein	NA	NA	NA	NA
WP_014195574.1\|1503336_1504215_-\|transposase	IS982-like element ISGsp1 family transposase	NA	NA	NA	NA
WP_033012441.1\|1504482_1505988_+	malate:quinone oxidoreductase	NA	NA	NA	NA
WP_025039163.1\|1506337_1506886_+	YpiB family protein	NA	NA	NA	NA
WP_011230895.1\|1506990_1508115_-	FAD-binding oxidoreductase	NA	NA	NA	NA
WP_011230896.1\|1508221_1509016_-	adenosylmethionine decarboxylase	NA	NA	NA	NA
WP_014195578.1\|1509152_1509992_-	MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_011230898.1\|1510361_1510619_+	membrane protein	NA	NA	NA	NA
WP_014195580.1\|1510849_1512511_-	hypothetical protein	NA	NA	NA	NA
WP_014195581.1\|1512526_1513048_-	RNA polymerase sigma factor	NA	NA	NA	NA
WP_011230900.1\|1513305_1513776_+	DUF2935 domain-containing protein	NA	NA	NA	NA
WP_011230901.1\|1513843_1514161_+	YbjQ family protein	NA	NA	NA	NA
WP_011230902.1\|1514354_1514663_+	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_011230903.1\|1514680_1515604_+	cation transporter	NA	NA	NA	NA
WP_014195583.1\|1515634_1516531_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_014195584.1\|1516760_1518590_+	assimilatory sulfite reductase (NADPH) flavoprotein subunit	NA	NA	NA	NA
WP_014195585.1\|1518616_1520338_+	assimilatory sulfite reductase (NADPH) hemoprotein subunit	NA	NA	NA	NA
WP_025039334.1\|1520690_1522157_+	aldehyde dehydrogenase family protein	NA	NA	NA	NA
WP_014195589.1\|1522608_1523556_+	ABC transporter permease	A0A2H4IY97	uncultured_Caudovirales_phage	5.0e-84	50.5
WP_014195590.1\|1523548_1524499_+	iron chelate uptake ABC transporter family permease subunit	NA	NA	NA	NA
WP_014195591.1\|1524492_1525248_+	ABC transporter ATP-binding protein	Q9EMR9	Amsacta_moorei_entomopoxvirus	2.3e-15	27.3
WP_014195592.1\|1525515_1526475_+	siderophore ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_041470282.1\|1526513_1527284_-	hypothetical protein	NA	NA	NA	NA
WP_014195594.1\|1527455_1531193_+	AAA family ATPase	NA	NA	NA	NA
WP_014195596.1\|1531571_1533005_+	site-specific DNA-methyltransferase	A0A2K5B2C1	Erysipelothrix_phage	9.8e-108	45.2
WP_014195597.1\|1533108_1533420_-	hypothetical protein	NA	NA	NA	NA
WP_014195598.1\|1533681_1535190_-	NCS1 family nucleobase:cation symporter-1	NA	NA	NA	NA
WP_014195599.1\|1535536_1536427_+	apolipoprotein acyltransferase	M1HUK8	Acanthocystis_turfacea_Chlorella_virus	2.1e-44	37.2
WP_031206329.1\|1536495_1537851_+	NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_014195600.1\|1537870_1539160_+	NAD-dependent dihydropyrimidine dehydrogenase subunit PreA	NA	NA	NA	NA
WP_041470258.1\|1539178_1540594_+	dihydropyrimidinase	NA	NA	NA	NA
WP_011230920.1\|1540673_1540904_+	hypothetical protein	NA	NA	NA	NA
WP_014195602.1\|1541210_1542839_+	PucR family transcriptional regulator	NA	NA	NA	NA
WP_014195603.1\|1543219_1544500_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_014195604.1\|1544897_1546364_+	CoA-acylating methylmalonate-semialdehyde dehydrogenase	NA	NA	NA	NA
WP_014195605.1\|1546393_1547746_+	aspartate aminotransferase family protein	NA	NA	NA	NA
WP_025039002.1\|1548171_1549158_+	acryloyl-CoA reductase	NA	NA	NA	NA
WP_014195607.1\|1549357_1550269_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_014195608.1\|1550394_1554954_+	glutamate synthase large subunit	NA	NA	NA	NA
WP_014195609.1\|1555100_1556585_+	glutamate synthase subunit beta	NA	NA	NA	NA
WP_014195603.1\|1556728_1558009_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_014195610.1\|1558558_1559161_+	phosphatase PAP2 family protein	NA	NA	NA	NA
WP_014195611.1\|1559328_1559991_+	hypothetical protein	NA	NA	NA	NA
WP_014195612.1\|1560142_1562236_+	DUF2157 domain-containing protein	NA	NA	NA	NA
WP_014195613.1\|1562260_1563133_-	phosphotransferase	NA	NA	NA	NA
WP_014195614.1\|1563129_1563858_-	NAD-dependent deacylase	S5M4R0	Bacillus_phage	2.9e-47	42.2
WP_011230934.1\|1564003_1564555_+	DJ-1/PfpI family protein	NA	NA	NA	NA
WP_014195615.1\|1564913_1566350_+	NAD-dependent malic enzyme	NA	NA	NA	NA
WP_014195616.1\|1566495_1567251_+	SIS domain-containing protein	NA	NA	NA	NA
WP_013145591.1\|1567330_1567555_+	hypothetical protein	NA	NA	NA	NA
WP_011230938.1\|1568021_1568756_+	sporulation protein	A0A0E3T7R5	Bacillus_phage	1.9e-38	64.0
WP_014195317.1\|1569201_1570338_-\|transposase	IS110-like element ISGka2 family transposase	Q9JMN8	Wolbachia_phage	1.6e-36	28.9
WP_014195619.1\|1571407_1572463_+\|transposase	IS200/IS605 family element transposase accessory protein TnpB	NA	NA	NA	NA

DBSCAN-SWA_6

1719264 : 1764956

Staphylococcus_phage(40.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_041470235.1\|1719264_1720440_-\|transposase	ISL3 family transposase	NA	NA	NA	NA
WP_014195727.1\|1721076_1722210_+\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_014194571.1\|1722483_1723848_-\|transposase	ISLre2 family transposase	NA	NA	NA	NA
WP_011231104.1\|1724690_1724840_+	YflJ family protein	NA	NA	NA	NA
WP_015374752.1\|1724964_1725159_+	NETI motif-containing protein	NA	NA	NA	NA
WP_014195730.1\|1725305_1725512_+	hypothetical protein	NA	NA	NA	NA
WP_011230853.1\|1726121_1727381_+	group II intron reverse transcriptase/maturase	NA	NA	NA	NA
WP_014195731.1\|1727455_1728748_-	HAMP domain-containing histidine kinase	NA	NA	NA	NA
WP_014195732.1\|1728788_1729055_-	hypothetical protein	NA	NA	NA	NA
WP_014195733.1\|1729154_1730303_-	Ger(x)C family spore germination protein	NA	NA	NA	NA
WP_014195734.1\|1730299_1731835_-	spore germination protein	NA	NA	NA	NA
WP_014195735.1\|1731831_1732929_-	endospore germination permease	NA	NA	NA	NA
WP_014195736.1\|1733188_1733467_+	DUF421 domain-containing protein	NA	NA	NA	NA
WP_014195739.1\|1733959_1734859_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	4.4e-21	31.0
WP_014195740.1\|1734866_1736543_+	ABC transporter permease	NA	NA	NA	NA
WP_014195741.1\|1736612_1736840_-	hypothetical protein	NA	NA	NA	NA
WP_014195742.1\|1736965_1738591_+	spore germination protein	NA	NA	NA	NA
WP_014195743.1\|1738587_1739790_+	Ger(x)C family spore germination protein	NA	NA	NA	NA
WP_014195744.1\|1739844_1740948_+	GerAB/ArcD/ProY family transporter	NA	NA	NA	NA
WP_014195746.1\|1741176_1742622_+	SpoIIE family protein phosphatase	NA	NA	NA	NA
WP_014195747.1\|1742634_1743060_+	ATP-binding protein	NA	NA	NA	NA
WP_011231124.1\|1743153_1743579_+	STAS domain-containing protein	NA	NA	NA	NA
WP_014195748.1\|1743985_1745722_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	3.1e-39	27.3
WP_025039155.1\|1745705_1747511_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	4.2e-55	30.6
WP_014195750.1\|1747670_1748318_-	MOSC domain-containing protein	NA	NA	NA	NA
WP_014195751.1\|1748323_1749328_-	LLM class flavin-dependent oxidoreductase	NA	NA	NA	NA
WP_014195752.1\|1749589_1750576_-	hypothetical protein	NA	NA	NA	NA
WP_025039156.1\|1750714_1751278_+	thioredoxin family protein	NA	NA	NA	NA
WP_014195755.1\|1751536_1751926_+	gamma-glutamylcyclotransferase	NA	NA	NA	NA
WP_014194949.1\|1752189_1753848_-\|transposase	IS1634 family transposase	NA	NA	NA	NA
WP_013523716.1\|1754033_1755392_+	type I glutamate--ammonia ligase	NA	NA	NA	NA
WP_011231133.1\|1755658_1756546_+	sulfite exporter TauE/SafE family protein	NA	NA	NA	NA
WP_014195758.1\|1756900_1758148_+\|transposase	IS200/IS605 family element transposase accessory protein TnpB	A0A1L2BWW3	Bacteriophage	6.4e-63	36.9
WP_011231135.1\|1758288_1759245_+	MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_014195759.1\|1759469_1759769_+	transporter suffix domain-containing protein	NA	NA	NA	NA
WP_011231137.1\|1759778_1760576_+	SGNH/GDSL hydrolase family protein	NA	NA	NA	NA
WP_011231138.1\|1760572_1761487_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	5.8e-37	37.7
WP_025039054.1\|1761479_1762460_+	ABC transporter permease	NA	NA	NA	NA
WP_021321939.1\|1762528_1762996_-	hypothetical protein	NA	NA	NA	NA
WP_011231140.1\|1763009_1763774_-	hypothetical protein	NA	NA	NA	NA
WP_011231141.1\|1763900_1764956_+\|transposase	IS200/IS605 family element transposase accessory protein TnpB	NA	NA	NA	NA

DBSCAN-SWA_7

1804265 : 1822767

Bacteriophage(50.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014195799.1\|1804265_1805513_+\|transposase	IS200/IS605 family element transposase accessory protein TnpB	A0A1L2BWW3	Bacteriophage	4.9e-63	36.9
WP_041470235.1\|1805597_1806773_-\|transposase	ISL3 family transposase	NA	NA	NA	NA
WP_014195800.1\|1807157_1809365_+	catalase/peroxidase HPI	NA	NA	NA	NA
WP_015374815.1\|1809761_1810187_+	NUDIX domain-containing protein	NA	NA	NA	NA
WP_014195802.1\|1810211_1810418_+	hypothetical protein	NA	NA	NA	NA
WP_014195804.1\|1810621_1811719_-	hypothetical protein	NA	NA	NA	NA
WP_014195805.1\|1811805_1812255_-	MarR family transcriptional regulator	NA	NA	NA	NA
WP_014195807.1\|1812654_1814313_+\|transposase	IS1634 family transposase	NA	NA	NA	NA
WP_014195809.1\|1815563_1816811_-\|transposase	IS481 family transposase	M4T586	Rhodobacter_phage	1.3e-10	25.1
WP_011229674.1\|1816953_1817517_-\|transposase	transposase	NA	NA	NA	NA
WP_021321441.1\|1818174_1818573_-	hypothetical protein	NA	NA	NA	NA
WP_014195814.1\|1820133_1821501_+\|transposase	ISLre2-like element ISGsp3 family transposase	NA	NA	NA	NA
WP_014195816.1\|1822209_1822767_-\|transposase	transposase family protein	NA	NA	NA	NA

DBSCAN-SWA_8

1837951 : 1894612

Bacillus_virus(22.22%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014195832.1\|1837951_1839610_+\|transposase	IS1634 family transposase	NA	NA	NA	NA
WP_014195833.1\|1840067_1840868_-	AAA family ATPase	NA	NA	NA	NA
WP_011229674.1\|1842254_1842818_-\|transposase	transposase	NA	NA	NA	NA
WP_014195836.1\|1843088_1844291_+\|transposase	IS21-like element IS5376 family transposase	A0A2L1IVA1	Escherichia_phage	6.0e-50	37.6
WP_014195837.1\|1844287_1845043_+	AAA family ATPase	U5N3V8	Enterobacteria_phage	7.1e-57	45.7
WP_020959521.1\|1845553_1846690_-\|transposase	IS110 family transposase	Q9JMN8	Wolbachia_phage	3.3e-42	29.4
WP_014195603.1\|1847273_1848554_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_011231223.1\|1850092_1850287_-	hypothetical protein	NA	NA	NA	NA
WP_014195842.1\|1850545_1851787_-	oligoribonuclease	NA	NA	NA	NA
WP_011231225.1\|1851804_1853709_-	hypothetical protein	NA	NA	NA	NA
WP_011231226.1\|1853719_1854595_-	MoxR family ATPase	R4TG24	Halovirus	9.8e-10	29.7
WP_011231227.1\|1854721_1855096_-	replication terminator protein	A0A0K2CP62	Brevibacillus_phage	2.1e-14	40.4
WP_014195843.1\|1855205_1856108_-	formyltetrahydrofolate deformylase	NA	NA	NA	NA
WP_014195844.1\|1856331_1857567_-	NO-inducible flavohemoprotein	NA	NA	NA	NA
WP_011231230.1\|1857738_1858182_+	nitric oxide-sensing transcriptional repressor NsrR	NA	NA	NA	NA
WP_011231232.1\|1858478_1859354_+	polyamine aminopropyltransferase	NA	NA	NA	NA
WP_011231233.1\|1859451_1860630_-	acyl-CoA/acyl-ACP dehydrogenase	NA	NA	NA	NA
WP_014195845.1\|1860734_1862234_-	aminotransferase class V-fold PLP-dependent enzyme	A0A1V0SL42	Klosneuvirus	1.6e-55	32.7
WP_011231235.1\|1862364_1862814_-	acyl-CoA thioesterase	NA	NA	NA	NA
WP_011231236.1\|1863222_1864635_-	sodium:proton antiporter	NA	NA	NA	NA
WP_014195847.1\|1864850_1865564_-	trehalose operon repressor	NA	NA	NA	NA
WP_014195848.1\|1865586_1867278_-	alpha,alpha-phosphotrehalase	NA	NA	NA	NA
WP_011231239.1\|1867392_1868811_-	PTS system trehalose-specific EIIBC component	NA	NA	NA	NA
WP_014195851.1\|1869107_1869839_+	MerR family transcriptional regulator	NA	NA	NA	NA
WP_013145319.1\|1869943_1870288_-	PilZ domain-containing protein	NA	NA	NA	NA
WP_014195852.1\|1870284_1872729_-	DNA topoisomerase IV subunit A	G3M9Z5	Bacillus_virus	8.3e-99	31.7
WP_011231243.1\|1872788_1874726_-	DNA topoisomerase IV subunit B	G3M9Z3	Bacillus_virus	1.9e-138	46.2
WP_011231244.1\|1874886_1875306_-	CoA-binding protein	NA	NA	NA	NA
WP_021322623.1\|1875797_1876388_-	hypothetical protein	NA	NA	NA	NA
WP_014195854.1\|1876753_1878430_-	AarF/ABC1/UbiB kinase family protein	A9YVW0	Ostreococcus_tauri_virus	4.1e-49	33.5
WP_011231247.1\|1878481_1878781_-	ATP synthase subunit B	NA	NA	NA	NA
WP_014195856.1\|1878927_1879776_+	MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_011231249.1\|1881774_1882407_+	DUF2238 domain-containing protein	NA	NA	NA	NA
WP_033007538.1\|1882453_1884124_-	hypothetical protein	NA	NA	NA	NA
WP_014195862.1\|1884402_1884690_-	hypothetical protein	NA	NA	NA	NA
WP_013523781.1\|1884683_1885331_-	pyroglutamyl-peptidase I	NA	NA	NA	NA
WP_014195863.1\|1885360_1886323_-	DUF979 domain-containing protein	NA	NA	NA	NA
WP_014195864.1\|1886323_1887010_-	DUF969 domain-containing protein	NA	NA	NA	NA
WP_014195865.1\|1887342_1887957_+	sulfite oxidase-like oxidoreductase	NA	NA	NA	NA
WP_081472556.1\|1888001_1888616_-	ECF transporter S component	NA	NA	NA	NA
WP_033845420.1\|1888959_1890177_-	threonine synthase	NA	NA	NA	NA
WP_011231254.1\|1890487_1891723_+	peptidase T	NA	NA	NA	NA
WP_014194949.1\|1892953_1894612_+\|transposase	IS1634 family transposase	NA	NA	NA	NA

DBSCAN-SWA_9

2016660 : 2046267

Bacillus_virus(50.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012749092.1\|2016660_2017941_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_014195983.1\|2018338_2019217_+\|transposase	IS982 family transposase	NA	NA	NA	NA
WP_049787570.1\|2019504_2020716_-	sugar ABC transporter permease	NA	NA	NA	NA
WP_014195986.1\|2020729_2022271_-	ATP-binding cassette domain-containing protein	G3M9Y6	Bacillus_virus	4.1e-19	28.1
WP_011231399.1\|2022352_2023432_-	sugar ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_014195987.1\|2023625_2024831_-	response regulator	NA	NA	NA	NA
WP_020279035.1\|2024844_2026620_-	sensor histidine kinase	NA	NA	NA	NA
WP_011231402.1\|2026655_2027663_-	sugar ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_014195991.1\|2028931_2030389_+	glycosyl transferase	NA	NA	NA	NA
WP_014195992.1\|2030484_2031921_-	aldehyde dehydrogenase family protein	NA	NA	NA	NA
WP_033012551.1\|2032567_2033218_+	cyclase family protein	NA	NA	NA	NA
WP_014195996.1\|2035208_2035442_-	hypothetical protein	NA	NA	NA	NA
WP_011229816.1\|2036332_2037523_-\|transposase	ISL3 family transposase	A0A0A8WEF4	Clostridium_phage	2.2e-28	25.2
WP_014195998.1\|2037577_2038441_-	hypothetical protein	NA	NA	NA	NA
WP_014194949.1\|2038594_2040253_+\|transposase	IS1634 family transposase	NA	NA	NA	NA
WP_128082669.1\|2040483_2040681_-	hypothetical protein	NA	NA	NA	NA
WP_014195999.1\|2040920_2041478_+\|transposase	transposase family protein	NA	NA	NA	NA
WP_011230382.1\|2042862_2043663_+	AAA family ATPase	NA	NA	NA	NA
WP_014196002.1\|2044639_2044903_-	hypothetical protein	NA	NA	NA	NA
WP_014196004.1\|2045133_2046267_+\|transposase	IS4 family transposase	NA	NA	NA	NA

DBSCAN-SWA_10

2323732 : 2379246

Bacillus_phage(22.22%)

protease,coat,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014196217.1\|2323732_2323963_+\|coat	spore coat associated protein CotJA	NA	NA	NA	NA
WP_014196218.1\|2323959_2324220_+\|coat	spore coat protein CotJB	NA	NA	NA	NA
WP_011231723.1\|2324254_2324824_+	hypothetical protein	NA	NA	NA	NA
WP_011231724.1\|2324849_2325296_-	YpbF family protein	NA	NA	NA	NA
WP_011231725.1\|2325394_2325925_-	LysM peptidoglycan-binding domain-containing protein	NA	NA	NA	NA
WP_011231726.1\|2325921_2326506_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_014196219.1\|2326489_2328013_-	ATP-dependent DNA helicase RecQ	F2NZ48	Diadromus_pulchellus_ascovirus	3.3e-61	39.0
WP_014196220.1\|2328000_2329047_-	Rrf2 family transcriptional regulator	NA	NA	NA	NA
WP_011231729.1\|2329301_2329550_+	ferredoxin	A0A127AYY7	Bacillus_phage	5.6e-19	53.3
WP_011231730.1\|2329714_2330218_+	inorganic diphosphatase	A0A2H4J8U1	uncultured_Caudovirales_phage	1.0e-27	44.8
WP_012820732.1\|2330439_2332014_+	phosphoglycerate dehydrogenase	A0A1B1IVB5	uncultured_Mediterranean_phage	1.0e-33	34.0
WP_011231732.1\|2332275_2333088_-	histidinol-phosphatase	NA	NA	NA	NA
WP_011231736.1\|2333396_2334491_-	UDP-glucose dehydrogenase	NA	NA	NA	NA
WP_011231737.1\|2334468_2335014_-	RNA polymerase sigma factor SigX	NA	NA	NA	NA
WP_014196222.1\|2335127_2335844_-	ATPase	NA	NA	NA	NA
WP_014196223.1\|2335836_2336325_-	ECF transporter S component	NA	NA	NA	NA
WP_011231740.1\|2336321_2336900_-	cob(I)yrinic acid a,c-diamide adenosyltransferase	NA	NA	NA	NA
WP_014196224.1\|2336914_2337331_-	hypothetical protein	NA	NA	NA	NA
WP_014196225.1\|2337282_2337915_-	histidine phosphatase family protein	NA	NA	NA	NA
WP_011231743.1\|2337872_2338661_-	adenosylcobinamide-GDP ribazoletransferase	NA	NA	NA	NA
WP_011231744.1\|2338657_2339215_-	bifunctional adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase	NA	NA	NA	NA
WP_025039355.1\|2339211_2340282_-	threonine-phosphate decarboxylase	NA	NA	NA	NA
WP_011231746.1\|2340238_2341213_-	cobalamin biosynthesis protein	NA	NA	NA	NA
WP_011231747.1\|2341209_2342682_-	ATP-binding cassette domain-containing protein	W8CYL7	Bacillus_phage	2.9e-14	34.0
WP_013144861.1\|2342678_2343713_-	iron ABC transporter permease	NA	NA	NA	NA
WP_011231749.1\|2343699_2344659_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_020278285.1\|2345336_2345951_-	hypothetical protein	NA	NA	NA	NA
WP_014196229.1\|2346135_2347500_-	amino acid permease	NA	NA	NA	NA
WP_041470264.1\|2347513_2348419_-	acetamidase/formamidase family protein	NA	NA	NA	NA
WP_014196231.1\|2348500_2349787_-	hypothetical protein	NA	NA	NA	NA
WP_014196233.1\|2350498_2351416_-	PEP phosphonomutase	NA	NA	NA	NA
WP_014195799.1\|2352230_2353478_-\|transposase	IS200/IS605 family element transposase accessory protein TnpB	A0A1L2BWW3	Bacteriophage	4.9e-63	36.9
WP_014196235.1\|2353716_2354448_-	GntR family transcriptional regulator	NA	NA	NA	NA
WP_014196236.1\|2354444_2355206_-	glucosamine-6-phosphate deaminase	NA	NA	NA	NA
WP_014196237.1\|2355196_2356399_-	N-acetylglucosamine-6-phosphate deacetylase	NA	NA	NA	NA
WP_014196238.1\|2356538_2358332_-	HAMP domain-containing protein	W8CYF6	Bacillus_phage	2.5e-36	35.6
WP_014196239.1\|2358331_2359078_-	response regulator transcription factor	W8CYM9	Bacillus_phage	7.3e-46	42.8
WP_011231762.1\|2359153_2360341_-	c-type cytochrome biogenesis protein CcsB	NA	NA	NA	NA
WP_014196240.1\|2360327_2361992_-	cytochrome c biogenesis protein	NA	NA	NA	NA
WP_011231764.1\|2362005_2362530_-	thiol-disulfide oxidoreductase ResA	NA	NA	NA	NA
WP_011231765.1\|2362672_2363404_-	rRNA pseudouridine synthase	NA	NA	NA	NA
WP_011231766.1\|2363536_2364070_-	spore maturation protein	NA	NA	NA	NA
WP_011231767.1\|2364069_2364666_-	spore maturation protein	NA	NA	NA	NA
WP_014196241.1\|2364658_2365807_-	D-alanyl-D-alanine carboxypeptidase	B6DZZ7	Stx2-converting_phage	3.9e-22	33.6
WP_025039220.1\|2366156_2367470_-	superoxide dismutase	Q56AR7	Bacillus_thuringiensis_phage	5.2e-39	43.6
WP_011231771.1\|2367827_2368229_-	hypothetical protein	NA	NA	NA	NA
WP_011231772.1\|2368247_2368901_-	SMC-Scp complex subunit ScpB	A0A1B1IVT7	uncultured_Mediterranean_phage	1.7e-14	35.3
WP_033007637.1\|2369076_2369832_-	segregation/condensation protein A	A0A1B1IVW1	uncultured_Mediterranean_phage	1.2e-08	25.3
WP_011231774.1\|2370026_2370566_+	DUF309 domain-containing protein	NA	NA	NA	NA
WP_011231775.1\|2370588_2370945_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_011231776.1\|2371065_2371530_-	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	1.0e-42	61.1
WP_014196246.1\|2371550_2372744_-	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	1.5e-117	54.1
WP_011231778.1\|2372764_2373409_-	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	1.9e-39	41.3
WP_014196247.1\|2373363_2374506_-	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	2.0e-55	36.3
WP_011231780.1\|2375007_2375448_-	peptidylprolyl isomerase	NA	NA	NA	NA
WP_014196252.1\|2376640_2377759_-\|transposase	IS200/IS605 family element transposase accessory protein TnpB	A0A0P0IJS6	Lactobacillus_phage	2.8e-86	45.1
WP_041470265.1\|2378100_2379246_+\|transposase	IS110 family transposase	Q9JMN8	Wolbachia_phage	4.4e-42	29.0

DBSCAN-SWA_11

2456095 : 2475839

Paenibacillus_phage(40.0%)

integrase,transposase

attL 2449767:2449782|attR 2477650:2477665

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2449767:2449782	attL	NA	NA	NA	NA
WP_014196309.1\|2456095_2456974_+\|transposase	IS982 family transposase	NA	NA	NA	NA
WP_014196310.1\|2457552_2458161_-	transglutaminase family protein	NA	NA	NA	NA
WP_014196311.1\|2458414_2459140_-	MOSC domain-containing protein	NA	NA	NA	NA
WP_033845382.1\|2459231_2459831_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_033845381.1\|2459997_2460516_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_033845380.1\|2460694_2461147_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_049787562.1\|2461193_2462081_-	aminoglycoside 6-adenylyltransferase	E4ZFP8	Streptococcus_phage	6.6e-54	39.4
WP_033845379.1\|2462342_2463032_-	M15 family metallopeptidase	NA	NA	NA	NA
WP_014194791.1\|2463567_2464737_-\|transposase	IS256 family transposase	A0A0K2CZ57	Paenibacillus_phage	3.4e-26	26.7
WP_033845378.1\|2464850_2465351_-	VanZ family protein	NA	NA	NA	NA
WP_081472566.1\|2465534_2465900_-	cupin domain-containing protein	NA	NA	NA	NA
WP_008880572.1\|2465948_2467118_+\|transposase	IS256 family transposase	A0A0K2CZ57	Paenibacillus_phage	1.9e-24	25.2
WP_033845200.1\|2467501_2467831_-	hypothetical protein	NA	NA	NA	NA
WP_014196315.1\|2468045_2468627_-	nucleotidyltransferase family protein	NA	NA	NA	NA
WP_014194800.1\|2468796_2470455_-\|transposase	IS1634 family transposase	NA	NA	NA	NA
WP_081472560.1\|2470658_2471291_-	methyltransferase	NA	NA	NA	NA
WP_041470289.1\|2472025_2472589_+	hypothetical protein	NA	NA	NA	NA
WP_014196317.1\|2472731_2473979_+\|transposase	IS481 family transposase	M4T586	Rhodobacter_phage	1.3e-10	25.1
WP_011229854.1\|2473971_2474772_+	AAA family ATPase	NA	NA	NA	NA
WP_014196318.1\|2474963_2475839_-\|integrase	tyrosine-type recombinase/integrase	A0A142F1N9	Bacillus_phage	8.3e-25	26.1
2477650:2477665	attR	NA	NA	NA	NA

DBSCAN-SWA_12

2675008 : 2735474

Salmonella_phage(20.0%)

protease,coat,tRNA,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014196415.1\|2675008_2676568_-\|coat	SafA/ExsA family spore coat assembly protein	NA	NA	NA	NA
WP_011232075.1\|2676726_2677830_-	quinolinate synthase NadA	NA	NA	NA	NA
WP_011232076.1\|2677844_2678675_-	carboxylating nicotinate-nucleotide diphosphorylase	NA	NA	NA	NA
WP_014196416.1\|2678703_2680260_-	L-aspartate oxidase	NA	NA	NA	NA
WP_021321862.1\|2680365_2681490_+	aminotransferase class V-fold PLP-dependent enzyme	NA	NA	NA	NA
WP_014196418.1\|2681505_2682045_+	transcription repressor NadR	NA	NA	NA	NA
WP_011232080.1\|2682153_2683002_-	prephenate dehydratase	NA	NA	NA	NA
WP_011232081.1\|2683023_2683467_-	ACT domain-containing protein	NA	NA	NA	NA
WP_011232082.1\|2683483_2684782_-	GTPase ObgE	NA	NA	NA	NA
WP_014196420.1\|2685019_2685568_-	sporulation protein	NA	NA	NA	NA
WP_011232084.1\|2685738_2686029_-	50S ribosomal protein L27	NA	NA	NA	NA
WP_011232085.1\|2686044_2686374_-\|protease	ribosomal-processing cysteine protease Prp	NA	NA	NA	NA
WP_011232086.1\|2686376_2686685_-	50S ribosomal protein L21	NA	NA	NA	NA
WP_021321861.1\|2687154_2688015_-	stage IV sporulation protein FB	NA	NA	NA	NA
WP_014196422.1\|2688007_2688775_-	M23 family metallopeptidase	NA	NA	NA	NA
WP_013524236.1\|2688750_2689011_-	hypothetical protein	NA	NA	NA	NA
WP_014196423.1\|2689034_2689841_-	septum site-determining protein MinD	NA	NA	NA	NA
WP_041470266.1\|2689843_2690536_-	septum site-determining protein MinC	NA	NA	NA	NA
WP_011232091.1\|2690576_2691095_-	rod shape-determining protein MreD	NA	NA	NA	NA
WP_011232092.1\|2691091_2691958_-	rod shape-determining protein MreC	NA	NA	NA	NA
WP_011232093.1\|2691977_2693000_-	rod shape-determining protein	NA	NA	NA	NA
WP_015375501.1\|2693157_2693838_-	JAB domain-containing protein	NA	NA	NA	NA
WP_014196426.1\|2693973_2694549_-	septum formation inhibitor Maf	NA	NA	NA	NA
WP_014196428.1\|2694985_2696101_-	hypothetical protein	NA	NA	NA	NA
WP_011232097.1\|2696217_2696679_-	type II secretion system protein	NA	NA	NA	NA
WP_014196429.1\|2696700_2697420_-	hypothetical protein	NA	NA	NA	NA
WP_014196430.1\|2697416_2697992_-	fimbrial protein	NA	NA	NA	NA
WP_014196431.1\|2697981_2698920_-	pilus assembly protein PilM	NA	NA	NA	NA
WP_014196432.1\|2698941_2699688_-	prepilin peptidase	NA	NA	NA	NA
WP_014196433.1\|2699716_2700235_-	prepilin-type N-terminal cleavage/methylation domain-containing protein	NA	NA	NA	NA
WP_014196434.1\|2700320_2701532_-	type II secretion system F family protein	NA	NA	NA	NA
WP_014196435.1\|2701518_2702574_-	type IV pilus twitching motility protein PilT	NA	NA	NA	NA
WP_014196436.1\|2702586_2704251_-	type II secretion system protein E	NA	NA	NA	NA
WP_014196437.1\|2704247_2705618_-	hypothetical protein	NA	NA	NA	NA
WP_014196438.1\|2705634_2706414_-	photosystem reaction center subunit H	NA	NA	NA	NA
WP_014196439.1\|2706403_2708020_-	hypothetical protein	NA	NA	NA	NA
WP_014196440.1\|2708163_2708784_+	prepilin-type N-terminal cleavage/methylation domain-containing protein	NA	NA	NA	NA
WP_014196441.1\|2708767_2709346_+	hypothetical protein	NA	NA	NA	NA
WP_014196442.1\|2709388_2711095_+	hypothetical protein	NA	NA	NA	NA
WP_014196443.1\|2711189_2713460_-	VWA domain-containing protein	J9Q6D6	Salmonella_phage	2.2e-08	29.1
WP_033012303.1\|2713528_2714824_-	bifunctional folylpolyglutamate synthase/dihydrofolate synthase	NA	NA	NA	NA
WP_014196445.1\|2715040_2717683_-\|tRNA	valine--tRNA ligase	A0A1V0S951	Catovirus	9.4e-165	42.4
WP_014194571.1\|2718233_2719598_-\|transposase	ISLre2 family transposase	NA	NA	NA	NA
WP_011232115.1\|2719874_2720063_+	hypothetical protein	NA	NA	NA	NA
WP_014196447.1\|2720101_2721133_-\|coat	spore coat protein YsxE	NA	NA	NA	NA
WP_014196448.1\|2721177_2722233_-	stage VI sporulation protein D	NA	NA	NA	NA
WP_011232118.1\|2722351_2723641_-	glutamate-1-semialdehyde 2,1-aminomutase	NA	NA	NA	NA
WP_013144588.1\|2723657_2724632_-	porphobilinogen synthase	NA	NA	NA	NA
WP_014196449.1\|2724632_2725403_-	uroporphyrinogen-III synthase	NA	NA	NA	NA
WP_014196450.1\|2725402_2726332_-	hydroxymethylbilane synthase	NA	NA	NA	NA
WP_014196451.1\|2726347_2727166_-	cytochrome c	NA	NA	NA	NA
WP_011232123.1\|2727176_2728541_-\|tRNA	glutamyl-tRNA reductase	NA	NA	NA	NA
WP_011232124.1\|2728707_2729193_+	hypothetical protein	NA	NA	NA	NA
WP_014196452.1\|2729234_2729822_-	YihA family ribosome biogenesis GTP-binding protein	NA	NA	NA	NA
WP_014196453.1\|2729818_2732161_-	endopeptidase La	A0A0R6PGP8	Moraxella_phage	1.7e-173	43.3
WP_014196454.1\|2732391_2734065_-\|protease	ATP-dependent protease LonB	A0A076FMQ5	Aureococcus_anophage	1.1e-12	32.7
WP_011232128.1\|2734208_2735474_-\|protease	ATP-dependent protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	6.3e-151	67.0

DBSCAN-SWA_13

3256002 : 3285887

Bacillus_phage(25.0%)

protease,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_041470268.1\|3256002_3257235_-\|protease	serine protease	U5Q0C0	Bacillus_phage	2.0e-16	39.5
WP_146331517.1\|3257847_3261486_-	endonuclease	NA	NA	NA	NA
WP_081472563.1\|3262011_3263481_+\|transposase	transposase	NA	NA	NA	NA
WP_146331540.1\|3263466_3266460_-	bifunctional metallophosphatase/5'-nucleotidase	S4VPC4	Pandoravirus	7.0e-23	25.4
WP_146331520.1\|3266753_3267797_+\|transposase	IS630 family transposase	S5VXX4	Leptospira_phage	5.6e-28	27.9
WP_049787565.1\|3267890_3268295_-	hypothetical protein	NA	NA	NA	NA
WP_014196821.1\|3268446_3269358_-	nucleotidyl transferase AbiEii/AbiGii toxin family protein	NA	NA	NA	NA
WP_013524694.1\|3269357_3269966_-	hypothetical protein	NA	NA	NA	NA
WP_014196822.1\|3270179_3272507_-	bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase	NA	NA	NA	NA
WP_014196823.1\|3273163_3274495_+\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_014196825.1\|3275086_3276334_-\|transposase	IS200/IS605 family element transposase accessory protein TnpB	A0A1L2BWW3	Bacteriophage	2.4e-62	36.9
WP_014196827.1\|3277109_3277904_-	ImmA/IrrE family metallo-endopeptidase	NA	NA	NA	NA
WP_014196828.1\|3277908_3278301_-	hypothetical protein	NA	NA	NA	NA
WP_041470270.1\|3278608_3279328_-	hypothetical protein	NA	NA	NA	NA
WP_014196823.1\|3284555_3285887_+\|transposase	IS4 family transposase	NA	NA	NA	NA

DBSCAN-SWA_14

3322377 : 3435376

Bacillus_phage(17.65%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014196869.1\|3322377_3323256_-\|transposase	transposase	NA	NA	NA	NA
WP_011232682.1\|3323469_3324813_-	6-phospho-beta-glucosidase	NA	NA	NA	NA
WP_011232683.1\|3324937_3325693_+	MurR/RpiR family transcriptional regulator	NA	NA	NA	NA
WP_014196870.1\|3325698_3327135_-	glycoside hydrolase family 1 protein	A0A0B5JD41	Pandoravirus	7.7e-52	31.6
WP_014196872.1\|3327508_3328876_-	FAD-binding protein	NA	NA	NA	NA
WP_014196873.1\|3328922_3329900_-	alpha-ketoacid dehydrogenase subunit beta	NA	NA	NA	NA
WP_033012451.1\|3329900_3330980_-	pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha	NA	NA	NA	NA
WP_014196875.1\|3331066_3332362_-	2-oxo acid dehydrogenase subunit E2	NA	NA	NA	NA
WP_014196877.1\|3333016_3333412_+	VOC family protein	NA	NA	NA	NA
WP_014196878.1\|3333516_3334503_+	Gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
WP_014196879.1\|3334598_3335036_-	DUF4275 family protein	NA	NA	NA	NA
WP_014196881.1\|3335264_3335684_-	arsenate reductase (thioredoxin)	A0A2H4PQT9	Staphylococcus_phage	3.6e-42	61.2
WP_033013564.1\|3335699_3336764_-	ACR3 family arsenite efflux transporter	NA	NA	NA	NA
WP_014196883.1\|3336788_3337136_-	winged helix-turn-helix transcriptional regulator	A0A218MNF3	uncultured_virus	2.1e-11	47.6
WP_014196884.1\|3337360_3337744_-	DUF1360 domain-containing protein	NA	NA	NA	NA
WP_014196885.1\|3337805_3337991_-	hypothetical protein	NA	NA	NA	NA
WP_011232696.1\|3338146_3339082_-	ribose ABC transporter substrate-binding protein RbsB	NA	NA	NA	NA
WP_011232697.1\|3339116_3340061_-	ribose ABC transporter permease	NA	NA	NA	NA
WP_014196887.1\|3340057_3341551_-	sugar ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	3.7e-17	27.3
WP_011232699.1\|3341572_3341983_-	D-ribose pyranase	NA	NA	NA	NA
WP_014196888.1\|3341982_3342876_-	ribokinase	NA	NA	NA	NA
WP_011232701.1\|3342872_3343862_-	LacI family transcriptional regulator	C6ZCU4	Enterobacteria_phage	2.9e-26	30.0
WP_011232703.1\|3344372_3344825_-	VanZ family protein	NA	NA	NA	NA
WP_011232704.1\|3345163_3345334_+	hypothetical protein	NA	NA	NA	NA
WP_014196889.1\|3345638_3346826_-\|transposase	IS701 family transposase	NA	NA	NA	NA
WP_014196892.1\|3349578_3349884_-	symporter	NA	NA	NA	NA
WP_011232711.1\|3349880_3350081_-	DUF3311 domain-containing protein	NA	NA	NA	NA
WP_014196893.1\|3350117_3351302_-	amidohydrolase	NA	NA	NA	NA
WP_014196894.1\|3351335_3352565_-	Zn-dependent hydrolase	NA	NA	NA	NA
WP_014196895.1\|3352721_3354050_-	hypothetical protein	NA	NA	NA	NA
WP_014196896.1\|3354306_3355680_-	UDP-glucose/GDP-mannose dehydrogenase family protein	A0A127AXI2	Bacillus_phage	1.0e-85	41.2
WP_014196898.1\|3355903_3357214_-	branched-chain amino acid transport system II carrier protein	NA	NA	NA	NA
WP_014196899.1\|3357786_3359154_-\|transposase	ISLre2 family transposase	NA	NA	NA	NA
WP_021321441.1\|3360714_3361113_+	hypothetical protein	NA	NA	NA	NA
WP_011229674.1\|3361770_3362334_+\|transposase	transposase	NA	NA	NA	NA
WP_011229853.1\|3362476_3363724_+\|transposase	IS481 family transposase	M4T586	Rhodobacter_phage	1.3e-10	25.1
WP_014196900.1\|3363716_3364517_+	AAA family ATPase	NA	NA	NA	NA
WP_014196901.1\|3364975_3366634_-\|transposase	IS1634 family transposase	NA	NA	NA	NA
WP_014195146.1\|3366830_3367388_-	signal peptidase I	NA	NA	NA	NA
WP_014195145.1\|3367899_3368778_-\|transposase	IS982 family transposase	NA	NA	NA	NA
WP_049787559.1\|3369092_3370433_-	SH3 domain-containing protein	NA	NA	NA	NA
WP_080729647.1\|3370842_3371076_-	hypothetical protein	NA	NA	NA	NA
WP_011232727.1\|3371203_3371914_+	plasmid pRiA4b ORF-3 family protein	A0A2H4PDG5	Mycobacterium_phage	6.1e-26	35.4
WP_014195141.1\|3372000_3373335_-	hypothetical protein	NA	NA	NA	NA
WP_014195139.1\|3373861_3376057_-	hypothetical protein	NA	NA	NA	NA
WP_014195137.1\|3376354_3377671_-	SEC-C domain-containing protein	NA	NA	NA	NA
WP_014195136.1\|3377863_3379531_+	hypothetical protein	NA	NA	NA	NA
WP_041470253.1\|3379527_3382290_+	DEAD/DEAH box helicase	E7DNC5	Pneumococcus_phage	5.8e-32	26.0
WP_011232734.1\|3382903_3383875_-	DUF1861 family protein	NA	NA	NA	NA
WP_014195131.1\|3384155_3384641_-	Appr-1-p processing protein	G3MBI4	Bacillus_virus	1.7e-43	56.1
WP_014195130.1\|3384644_3385022_-	DUF488 family protein	NA	NA	NA	NA
WP_011232737.1\|3385043_3385475_-	hypothetical protein	NA	NA	NA	NA
WP_011232738.1\|3385477_3386791_-	ATP-binding protein	NA	NA	NA	NA
WP_011232739.1\|3386833_3387721_-	UTP--glucose-1-phosphate uridylyltransferase GalU	A0A127AW70	Bacillus_phage	1.1e-77	52.7
WP_011232740.1\|3388002_3389061_-	glycosidase	NA	NA	NA	NA
WP_014195127.1\|3389063_3390011_-	DUF1861 family protein	NA	NA	NA	NA
WP_011232742.1\|3390052_3390883_-	carbohydrate ABC transporter permease	NA	NA	NA	NA
WP_011232743.1\|3390869_3391748_-	sugar ABC transporter permease	NA	NA	NA	NA
WP_014195126.1\|3391749_3393075_-	extracellular solute-binding protein	NA	NA	NA	NA
WP_014195125.1\|3393570_3394584_+	LacI family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_013524772.1\|3394623_3395517_-\|transposase	Rpn family recombination-promoting nuclease/putative transposase	NA	NA	NA	NA
WP_011232748.1\|3396741_3397215_+	hypothetical protein	NA	NA	NA	NA
WP_011232749.1\|3397258_3397459_-	hypothetical protein	NA	NA	NA	NA
WP_011232750.1\|3397692_3398190_+	L,D-transpeptidase family protein	NA	NA	NA	NA
WP_014195121.1\|3398360_3399365_+	hypothetical protein	NA	NA	NA	NA
WP_011232752.1\|3399508_3400108_-	hypothetical protein	NA	NA	NA	NA
WP_011232753.1\|3400181_3401948_-	DUF262 domain-containing protein	NA	NA	NA	NA
WP_011232754.1\|3402204_3402657_+	N-acetyltransferase	NA	NA	NA	NA
WP_011232755.1\|3403006_3403264_-	DUF2283 domain-containing protein	NA	NA	NA	NA
WP_011232756.1\|3403232_3403628_-	hypothetical protein	NA	NA	NA	NA
WP_025039361.1\|3403627_3403906_-	DUF3467 domain-containing protein	NA	NA	NA	NA
WP_014194630.1\|3404438_3404996_+\|transposase	transposase family protein	NA	NA	NA	NA
WP_014196903.1\|3405136_3406390_+\|transposase	IS481 family transposase	M4T586	Rhodobacter_phage	6.3e-10	25.8
WP_014196904.1\|3406382_3407183_+	AAA family ATPase	NA	NA	NA	NA
WP_014196905.1\|3407380_3407776_-	hypothetical protein	NA	NA	NA	NA
WP_014196906.1\|3407781_3409308_-	YifB family Mg chelatase-like AAA ATPase	NA	NA	NA	NA
WP_011232761.1\|3410251_3410998_-	hypothetical protein	NA	NA	NA	NA
WP_014196909.1\|3410999_3411872_-	hypothetical protein	NA	NA	NA	NA
WP_014196910.1\|3412020_3413454_-	caspase family protein	NA	NA	NA	NA
WP_011229816.1\|3413995_3415186_-\|transposase	ISL3 family transposase	A0A0A8WEF4	Clostridium_phage	2.2e-28	25.2
WP_014196914.1\|3417622_3418771_-	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_014196915.1\|3418811_3419444_-	acetyltransferase	NA	NA	NA	NA
WP_041470271.1\|3419443_3420076_-	sugar transferase	NA	NA	NA	NA
WP_014196917.1\|3420090_3421113_-	UDP-glucose 4-epimerase GalE	A0A2K9L5H6	Tupanvirus	2.9e-93	50.5
WP_014196918.1\|3421137_3422280_-	glycosyltransferase family 4 protein	NA	NA	NA	NA
WP_014196919.1\|3422340_3423669_-	UDP-glucose/GDP-mannose dehydrogenase family protein	A0A127AXI2	Bacillus_phage	1.3e-93	42.3
WP_014196920.1\|3423722_3424727_-	NAD-dependent epimerase	A0A2K9KZK0	Tupanvirus	1.4e-20	25.0
WP_014196921.1\|3424723_3425884_-	glycosyltransferase family 4 protein	NA	NA	NA	NA
WP_146331543.1\|3425909_3427040_-	glycosyltransferase	NA	NA	NA	NA
WP_014196923.1\|3426945_3428244_-	hypothetical protein	NA	NA	NA	NA
WP_025038875.1\|3428435_3429545_-	glycosyltransferase	NA	NA	NA	NA
WP_014196925.1\|3429578_3430586_-	glycosyltransferase family 2 protein	A0A1V0SAH6	Catovirus	1.8e-07	29.4
WP_014196926.1\|3430632_3432033_-	flippase	NA	NA	NA	NA
WP_014196929.1\|3433581_3434136_-	hypothetical protein	NA	NA	NA	NA
WP_014195149.1\|3434497_3435376_-\|transposase	IS982-like element ISGsp1 family transposase	NA	NA	NA	NA

DBSCAN-SWA_15

3566072 : 3575892

uncultured_Mediterranean_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011232933.1\|3566072_3567293_-	PDZ domain-containing protein	A0A1B1IT49	uncultured_Mediterranean_phage	6.1e-18	28.8
WP_011232934.1\|3567394_3568189_-	MBL fold metallo-hydrolase	A0A0C5AJ83	Bacteriophage	6.5e-45	37.7
WP_011232935.1\|3568195_3568978_-	hypothetical protein	NA	NA	NA	NA
WP_011232936.1\|3568964_3570293_-	hypothetical protein	NA	NA	NA	NA
WP_014197025.1\|3570285_3572115_-	cell wall metabolism sensor histidine kinase WalK	A0A1V0SGX0	Hokovirus	1.2e-22	27.0
WP_011232938.1\|3572121_3572835_-	response regulator transcription factor	W8CYM9	Bacillus_phage	1.7e-44	41.4
WP_011232939.1\|3573023_3574310_-	adenylosuccinate synthase	A0A2P1EKE7	Megavirus	8.6e-71	36.7
WP_011232940.1\|3574527_3575892_-	replicative DNA helicase	A0A1P8VVQ6	Streptococcus_phage	7.9e-123	52.8

Anti-CRISPR protein detection

Acr_ID: NC_016593.1|WP_014195851.1|1869107_1869839_+|MerR-family-transcriptional-regulator

Click the colored protein region to show detailed information

Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NC_016593.1|WP_014195851.1|1869107_1869839_+|MerR-family-transcriptional-regulator

1869107_1869839_+

243 aa aa

1837951-1894612

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NC_016593_5	Orphan	5.1\|3501425\|37\|NC_016593\|CRISPRCasFinder	3501425-3501461	37	1853621-1853585	0

1. spacer 5.1|3501425|37|NC_016593|CRISPRCasFinder matches to NC_016593 position: 1853621-1853585, mismatch: 0

gccgcgacgttgccatccagttcgccgcccattccgg	CRISPR spacer
gccgcgacgttgccatccagttcgccgcccattccgg	Protospacer
*************************************

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_016593

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CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

Click the colored protein region to show detailed information