CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_016111	Streptomyces cattleya NRRL 8057 = DSM 46488, complete genome	8 crisprs	WYL,csa3,DEDDh,cas3,DinG,cas4	1	4	3	0
NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	4 crisprs	csa3,WYL	1	9	0	0

1. NC_016111

CRISPR-Cas detection and classification

Crispr_ID: NC_016111_1

• CRISPR_ID: NC_016111_1
• CRISPR_location: 643614-643825
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 3 spacers

Consensus repeat of NC_016111_1

Consensus_repeat	Method
GTCGTCCCCGCCAGCGCGGGGGTAGCCCG	PILER-CR
GTCGTCCCCGCCAGCGCGGGGGTAGCCC	CRISPRCasFinder
GTCGTCCCCGCCAGCGCGGGGGTAGCCCG	CRT

spacers of NC_016111_1

>1.1|643643|32|NC_016111|PILER-CR,CRT
TGGGGTATGTGTGTCCCACTCCGCCAGGTCGA
>1.2|643704|32|NC_016111|PILER-CR,CRT
AACCGAGGGCGGCGCATGCCACCCGTGCGATC
>1.3|643642|33|NC_016111|CRISPRCasFinder
GTGGGGTATGTGTGTCCCACTCCGCCAGGTCGA
>1.4|643703|33|NC_016111|CRISPRCasFinder
GAACCGAGGGCGGCGCATGCCACCCGTGCGATC
>1.5|643764|33|NC_016111|CRISPRCasFinder
CATCGCCACCCGGCCCCGCACGCACGAGCGCGT
>1.6|643765|32|NC_016111|CRT
ATCGCCACCCGGCCCCGCACGCACGAGCGCGT

CRISPR arrays and Neighbor proteins around NC_016111_1

CRISPR arrays

The CRISPR arrays of NC_016111_1

>merge|NC_016111|1|643614-643825|PILER-CR,CRISPRCasFinder,CRT
GTCGTCCCCGCCAGCGCGGGGGTAGCCCGTGGGGTATGTGTGTCCCACTCCGCCAGGTCGAGTCGTCCCCGCCAGCGCGGGGGTAGCCCGAACCGAGGGCGGCGCATGCCACCCGTGCGATCGTCGTCCCCGCCAGCGCGGGGGTAGCCCCATCGCCACCCGGCCCCGCACGCACGAGCGCGTGTCGTCCCCGCGAGCGCGGGGTTAGGTCG

>NC_016111|1|1|643614-643764|PILER-CR
GTCGTCCCCGCCAGCGCGGGGGTAGCCCG	TGGGGTATGTGTGTCCCACTCCGCCAGGTCGA
GTCGTCCCCGCCAGCGCGGGGGTAGCCCG	AACCGAGGGCGGCGCATGCCACCCGTGCGATC
GTCGTCCCCGCCAGCGCGGGGGTAGCCCC

>NC_016111|1|1|643614-643824|CRISPRCasFinder
GTCGTCCCCGCCAGCGCGGGGGTAGCCC	GTGGGGTATGTGTGTCCCACTCCGCCAGGTCGA
GTCGTCCCCGCCAGCGCGGGGGTAGCCC	GAACCGAGGGCGGCGCATGCCACCCGTGCGATC
GTCGTCCCCGCCAGCGCGGGGGTAGCCC	CATCGCCACCCGGCCCCGCACGCACGAGCGCGT
GTCGTCCCCGCGAGCGCGGGGTTAGGTC

>NC_016111|1|1|643614-643825|CRT
GTCGTCCCCGCCAGCGCGGGGGTAGCCCG	TGGGGTATGTGTGTCCCACTCCGCCAGGTCGA
GTCGTCCCCGCCAGCGCGGGGGTAGCCCG	AACCGAGGGCGGCGCATGCCACCCGTGCGATC
GTCGTCCCCGCCAGCGCGGGGGTAGCCCC	ATCGCCACCCGGCCCCGCACGCACGAGCGCGT
GTCGTCCCCGCGAGCGCGGGGTTAGGTCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016111.1|WP_014141323.1|649284_649698_-|hypothetical-protein	unknown	unknown	gnl|CDD|235450
NC_016111.1|WP_014141319.1|646784_648182_-|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_014141324.1|649779_650193_-|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_014141320.1|648193_648637_-|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_042507551.1|629657_629882_+|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_014141317.1|645502_646234_-|protein-phosphatase-2C-domain-containing-protein	unknown	unknown	gnl|CDD|223704
NC_016111.1|WP_014141301.1|630339_630978_+|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_014141307.1|636484_636682_+|FxLD-family-lantipeptide	unknown	unknown	gnl|CDD|275157
NC_016111.1|WP_014141318.1|646356_646662_-|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_014141305.1|633831_634977_+|methyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|275041
NC_016111.1|WP_014141304.1|632860_633709_+|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_014141302.1|631113_632016_+|endonuclease/exonuclease/phosphatase-family-protein	unknown	unknown	unknown
NC_016111.1|WP_014141314.1|643977_644295_+|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|367559
NC_016111.1|WP_014141321.1|648699_648873_-|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_014141303.1|632171_632864_+|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_014141308.1|636759_639822_+|lantibiotic-dehydratase	unknown	unknown	gnl|CDD|377403
NC_016111.1|WP_014141309.1|639818_641045_+|lanthionine-synthetase-C-family-protein	unknown	unknown	gnl|CDD|271201
NC_016111.1|WP_014141322.1|648869_649211_-|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_014627360.1|645315_645522_+|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_014141306.1|635192_636470_+|methyltransferase,-FxLD-system	unknown	unknown	gnl|CDD|275158

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016111.1|WP_014141317.1|645502_646234_-|protein-phosphatase-2C-domain-containing-protein	gnl|CDD|223704	COG0631, PTC1, Serine/threonine protein phosphatase [Signal transduction mechanisms].	6.45522e-16
NC_016111.1|WP_014141323.1|649284_649698_-|hypothetical-protein	gnl|CDD|235450	PRK05416, PRK05416, RNase adapter RapZ.	1.47122e-16
NC_016111.1|WP_014141314.1|643977_644295_+|helix-turn-helix-transcriptional-regulator	gnl|CDD|367559	pfam03551, PadR, Transcriptional regulator PadR-like family. Members of this family are transcriptional regulators that appear to be related to the pfam01047 family. This family includes PadR, a protein that is involved in negative regulation of phenolic acid metabolism.	4.59965e-09
NC_016111.1|WP_014141308.1|636759_639822_+|lantibiotic-dehydratase	gnl|CDD|377403	pfam04738, Lant_dehydr_N, Lantibiotic dehydratase, C-terminus. Lantibiotics are ribosomally synthesized antimicrobial agents derived from ribosomally synthesized peptides. They are produced by bacteria of the Firmicutes phylum, and include mutacin, subtilin, and nisin. Lantibiotic peptides contain thioether bridges termed lanthionines that are thought to be generated by dehydration of serine and threonine residues followed by addition of cysteine residues. This family constitutes the N-terminus of the enzyme proposed to catalyze the dehydration step, via glutamylation of the substrate during lantibiotic biosynthesis. The enzyme dehydrates Ser/Thr residues in the precursor by glutamylation.	0
NC_016111.1|WP_014141309.1|639818_641045_+|lanthionine-synthetase-C-family-protein	gnl|CDD|271201	cd04793, LanC, Cyclases involved in the biosynthesis of lantibiotics. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links called lanthionines (Lans) or methyllanthionines (MeLans) in addition to 2,3-didehydroalanine (Dha) and (Z)-2,3-didehydrobutyrine (Dhb). These unusual amino acids are introduced by the dehydration of serine and threonine residues, followed by thioether formation via addition of cysteine thiols, catalysed by LanB and LanC or LanM. LanC, the cyclase component, is a zinc metalloprotein, whose bound metal has been proposed to activate the thiol substrate for nucleophilic addition. Also contains SpaC (the cyclase involved in the biosynthesis of subtilin), NisC, and homologs.	5.35006e-111
NC_016111.1|WP_014141307.1|636484_636682_+|FxLD-family-lantipeptide	gnl|CDD|275157	TIGR04363, hypothetical_protein, FxLD family lantipeptide. Members of this protein family occur with a cassette of lanthionine-type peptide modification enzymes. Members are small (about 60 amino acids long), rich in Cys, and variable in copy number per genome (from one to three). These features suggest that members of this family are modified to become lantipeptides, although not necessarily a lantibiotic. There is no GlyGly cleavage motif to separate a leader peptide from core region.The considerable abundance in Streptomyces and relatively strong consideration hints at a non-antibiotic function. The motif FxLD in the N-terminal region is nearly invariant.	7.31458e-07
NC_016111.1|WP_014141305.1|633831_634977_+|methyltransferase-domain-containing-protein	gnl|CDD|275041	TIGR04188, conserved_hypothetical_protein, methyltransferase, ATP-grasp peptide maturase system. Members of this protein family are predicted SAM-dependent methyltransferases that regularly occur in the context of a putative peptide modification ATP-grasp enzyme (TIGR04187, related to enzymes of microviridin maturation) and a putative ribosomal peptide modification target (TIGR04186).	3.88823e-77
NC_016111.1|WP_014141306.1|635192_636470_+|methyltransferase,-FxLD-system	gnl|CDD|275158	TIGR04364, methyltran_FxLD, methyltransferase, FxLD system. Members of this family resemble occur regularly in the vicinity of lantibiotic biosynthesis enzymes and their probable target, the FxLD family of putative ribosomal natural product precursor (TIGR04363). Members resemble protein-L-isoaspartate O-methyltransferase (TIGR00080) and a predicted methyltranserase, TIGR04188, of another putative peptide modification system.	0

Protein sequences

>NC_016111.1|WP_014141309.1|639818_641045_+|lanthionine-synthetase-C-family-protein
MTTPVSLSTAEHLARYLALPEPASLDKPGEAQSLARGPAGIALLHIERAHTGDGTWQQAHAWITRAVAGPISAAENTGLYLGAPAVAYMLHTAAIGSTTRYRGALQDVDKHVTAAAHQHTDAAMARLGGGQLPTFREYDIFSGLTGTGALILHRAPGSSALGRILDYLVALIRPVTIDGQELPGWWACHDPRLRTSARYPDGHGNFGAAHGITGPLLLLSQAARRGITVDGHHEAIGTILAWLDTWRQDGDAGPWWPEHITLGELRTGRARQAGPARPSWCYGTPGIARAGQLAAFATGDRRRQQLYEDALHQCLADPVQMGRLTDAGLCHGWAGVYQTVWRAARDATTPALATHLPRLAEALVEHAGSGGEDEPGFLNGAAGTALALTTAARDAAPISGWDACLLIN
>NC_016111.1|WP_014141308.1|636759_639822_+|lantibiotic-dehydratase
MTSDVSYQWLPCALLRATTAPGTLDLPRDLDLASDTTAAREWLATVWQRQEVRDTLAVASPALCRRISEVLAGERCQPRQVRRAAISMASYLLRWQQRPTPFGLFAGVAAVRITDAAKAAWRGTHRTVARADACWLAGIIERLNGCPPLVDRLTVVASNAGQVRGDRYVVPGLPGEQPQELAPVEVSVRHTRPVAAALDAARMPIRYGELRALLAQQFPAAPVGRIDAMLGGLVARDILISSLRAPMTRLDALGHVCDLLEAAEAHTIPDITDLVTELYALRHELSRSVVIDARPARSDLADRMQALSDVASVPLVIDTGLDCDVEIPEHVAVEAQEAVNVLHRVSAHPSGSPAWRDYHARYRTRYGPDAVVPVLDLVADSGLGLPAGYLGSAYKTAARQMTERDEKLLALVQQTILDGAPEIILTESLITELSDADTPTRCAPYAEVAVEVHAASPEDLARGAFRLLVTGTPRPASSMAGRFAHLLPAQTRAQLADAYRAAAPGALAAQLSFVPRKRRNENVARTERLLPQVISLSEHPMPDQSVIPLSDLAVTADTRHLFLVRLSTGMRIEPRVAHALEAGVHTPPLARFLGEISTARCAVYRYFDFGAAARLPYLPRVRHKRTILAPARWLLTGPDLPGPGAPGHAWDAAFEAWRTRRRVPDLVTLAEHDQRLRMDLTHPVHRLVLRTRLNATGHLELREAATARDLAWLGRAHELLLPLALANPTPARIPERTLVPTVTADAGHLPGHSTVLAAHLHAHPDRYDEILTGHLPSLIDSLQGTPLWWFNRQRTTPRPDADQHLALYLRLPEPDDYSRTAEQLHAWTRQLRRQRLVAQLTLATYQPPTGQYGHGPALEAAYEVFAADSAAALAQIRMTTRGGTDPLALSAASMVDLAARLAPSAADGLTWLTEQLPHEPGRLDRSLREQTLDIADPYGRRTTLRARPCGDEVAAAWQARAATLAAYREHLAGQRQPFTVLRPLLRLHQTRTLGPDPTLRRITARLARACALRYTAGTTQ
>NC_016111.1|WP_014141307.1|636484_636682_+|FxLD-family-lantipeptide
MPDVLLPDNTRLADDPADDDFTLDVRIVVATGPMAGYADCPTDDGCGNTCANGASACDSYIGDPA
>NC_016111.1|WP_014141306.1|635192_636470_+|methyltransferase,-FxLD-system
MTDVTSDHEHAARLRDAVVDELVDRGEIVSKDVEAVMRKVARHAFTPEASLEDAYHTYNAVVTKRNEHGRAVSSVSAPQIQAFMLEQAEVRPGMRVLEIGSGGLNAAYLAELVGNTGEVTTVDIDPEVTERAARLLAQAGYPDVRVLLADATEGVAAHAPYDVIMVTVGSWDIPPAWIEQLTATGRLVVPLRIRGLVRSVAFQRQGNRLVSTSARICGFVSMQGAGAHEADLLLVNGTEEIVLRFDDGLPADPGQLNNAVRSPRVEISTGVLVRRMEPVDTLQLYMATVLPGFCTMSVDAGLDTGLVAPRNKGFSMACVEGANFAYITTRIAEDDAFAEFVVHAFGPGGPTLAEAIADHVRTWDREHRGGPGPRITLYPAGTPDDQIPELPGGRVIDKTHCRVTLSWSPTATAAEDRATQHHTTE
>NC_016111.1|WP_014141305.1|633831_634977_+|methyltransferase-domain-containing-protein
MTWRDRARDLAATLEKTGDLHDHRWRAAVEEVPRHEFVPAFYLPGDDDPGVWHRVGVDHDGYLDAVYTDQTLVTYLDPHTAANAGTGLAGVPSSSSTRPGLVVRMLETLGVEAHHAVLDIGTATGYQAALIAHRLNASGRLTTADIDPLFTTHAQAALQLLGYTPEVVTCDATTYLWSEMFDRIISGCALPRITDTLRAALRPGGRLIAPLMPPLGCALVVLTAEDHGVLEGRFLPGQVAVMPARQHPASYPAPAAGPGVTAATITGTSTVPVEAFDDPCFLFLLAGHLPGVDLQTGDGDTVPVRRLVMPDGSWAEGRFAPHQPVLWREVGDHRIRRTLNRCWTWYLQHDRPAFDRFGLTITSTGTHRLWFDSPNHVLTSF
>NC_016111.1|WP_014141304.1|632860_633709_+|hypothetical-protein
MTSTRMPTTTAVPDHDFRALMSKRAAGWSRRKPPSAFRYGFPFHAVPQVLAHFTAKQHSEPWLAGRLVRSLAADIARWQGVWSLHQPSGLYRLDDRGPGSLCHALLIDPAGVILAYTTSHSDAACRRTGIPAPPAGQPWLASTTERIPPDGAVNVWRHILRVSTSAPIAVSGAAYNGYKDCRTHDPGTHPLPQTMPNWYLAAQASATRLAPLIPHSPGQTYRIHDGTGLAWLIRIPTHPGRKPTALRVQMSPADEPKIIPLAPRAAAQAMTDPQVSLQDADR
>NC_016111.1|WP_014141303.1|632171_632864_+|hypothetical-protein
MDSDADVFVLHDVPNWPQEDLDCLARSGYRLERAVMTDRPGYHTLLLCRPPWYTRGVWNLAGRHFHPGLVRMRLIHLPPDPGQDLYGISGLRPAEEGAEVLLMALHMSERGRRLMRRATAAPGLAGGELVAAVEQLSVQAEAEHGPDWARWPEPPHTRPAGQPVDPTFGLHDPAAPRVLILSHCTTDDDTGPETADQVVISGAASSTVHCPPAPTSADDQMCLVDLEIPR
>NC_016111.1|WP_014141302.1|631113_632016_+|endonuclease/exonuclease/phosphatase-family-protein
MKSVVTFATFNLEQNGFGCRERREQAYALINKVRPDVLFRQEMPGADADYHQHVREAEQALAMVGYLGEGSRTALFVRPGLFDVLKGWPSPQPVTMSAPTALTVQLRAAGPASTPLILVADHLSYSTPTLRLIGAGELTRFNDKWVVLPDGTRRRGLAVAGLDANSYPSGEFLTAEPRLPRVEEIQDRPHRAHRTVLAADGRRVMDQAPHDFLVTAGLDDVARVCAAHSPGAVAATMGPSITHGPATRVDWVMASRHLRDAWVGGEVIDASTVSDHNIFVGRADLQILVDILSGPLPEFG
>NC_016111.1|WP_014141301.1|630339_630978_+|hypothetical-protein
MTPTKRPLVVPYIAPWSGERTAAHLLVHDARGTGIVYADEHPFDRDSHGVLYKRTLHRPGVGDPLLGDVHGPRQRRAMRKLLCQVCGRAADRDARGWLWLLRADPRTPEWPEGEMTTHPPLCRRCARISVRQCPHLNDQAVAARVGRPEIDHVLAVRYRKGGTAPEPAGHADVVPIADPAIRWYLATQLVATLTGCTVVDLKTELGDRSSAV
>NC_016111.1|WP_042507551.1|629657_629882_+|hypothetical-protein
MSPEKPSWLRMGKPVIDAATGREGTVSGIGEPWMTNRPPDVVYVRPVGGGIEWRVPIDRVRPGPVPSHPAGGGR
>NC_016111.1|WP_014141314.1|643977_644295_+|helix-turn-helix-transcriptional-regulator
MASIRLTRPTLEVLQVLLASTDDDPAWGLRICEEAALGSGTVYPILDRLTERGWIASQEEVVPHPGRPARRFYTLTGTGRKLAEEAVRSRLGQRGTPSPALGADA
>NC_016111.1|WP_014627360.1|645315_645522_+|hypothetical-protein
MRVYAEGAWRRAWVLQRQDWPDGRTAYMLDVLLPSRPPIPGDPHSQDYFVRTYWWGTGSMTPVKRSSS
>NC_016111.1|WP_014141317.1|645502_646234_-|protein-phosphatase-2C-domain-containing-protein
MTTARAQTVTTATATRQGSRPCNADAAAVHRVPGTRLIGAAVVDGIGSNPAVARLAEIAAEVIARVAPRKTPVLGILAAAELVAAPADRNPIDPDAVAVAAVAEPGRRTGIAWTGDARAYGWDGTTLTQLTTDQTVGEYLRANSGGGGPVELLAQAHDNWLRASLGRSSISTVHTVGTDARLVLLTSDGVHDHIPHKVLEALVREHAENAQALVEAVVEVAEPDETGYRDDATAVVLVTTTTA
>NC_016111.1|WP_014141318.1|646356_646662_-|hypothetical-protein
MTPENPHGETEAGVTIQYSVKELIEGLHRKLDSLMTLLHGKADSVTVKALEVRMDRVEEHIATQTHHRELEEKRADWRRWLIPTLATLILAAATVASLLKT
>NC_016111.1|WP_014141319.1|646784_648182_-|hypothetical-protein
MPRTMYDAVTPANIPANATMVAGYADGRYANLDELRARFPAATIISIAVRWTTRAQVLDVESGDATPEQAVQWCTQTMADTPNHELTVYCNTSQWPSVRAAFQAAGITEPNYWVAAYDGDPTIPAGAIAKQYLGDYHGYDKSAVVDYWPGVDTSPPPGGEFYPGANRSHWYEQAYPGDPMRVNTIIWHSTETTVLPDYGGGSIAPTLTAVPNWREQRLDWWQHFPFDTSARALVHDRALIGTNTLNVAQIEIVGTCDPATHAAWTQAGIQHLYMPALPGWAVRDLAACARWAHTTHGVPLTSGLRWLPYPASFGANNGVRMDAAAWSAFRGHAGHMHVPQNDHGDPGVFPIAAILSNTPVLEDDMPQWHTGPITAGSEPTVVLVPHGNAWQAAPKRTLHLGMDQLGAPAATATVRVAVHNGIRWGAVSTVKVTAAGSTVDVDVTGAVKVSLQTTTTGLAYAVETW
>NC_016111.1|WP_014141320.1|648193_648637_-|hypothetical-protein
MPTHPHRQVAAHDQSVTHRYVMHYPAHAPREGDPHYRAFELYRRHHRQGAVCYVGERAGHDQCAGDLELHHSVLEFAVVNAVDAAALHKDFPEVREDATAEEIAQWAESSPGQFRWLCAYHHRGAGGAHTASHADWSAQLYVPHLIS
>NC_016111.1|WP_014141321.1|648699_648873_-|hypothetical-protein
MTTVVTGLSITAAVIGVLAAAIKAGRWITSVENRLTRLQRDVTRLGRAVSMRDHPEP
>NC_016111.1|WP_014141322.1|648869_649211_-|hypothetical-protein
MDRIRAFNERLADWITAALSSMWAAYLFTGLALVSLPQALAGGIAPTVTWTAQTFIQLVALAVLGAGQDKQTRRWAATLRETHDAVLQQLEGVTELVAALHAKHDAVHSPEPS
>NC_016111.1|WP_014141323.1|649284_649698_-|hypothetical-protein
MTPHHTASAKVVVRSIGTRHPDAIGLLRSGLYFDLGHLRNPHADRIMRYKTGLSEDVRAHVLSTPGATHLAVQIAEAAKAQLYSFANRNQDPVTVTLACSGGRHRSVVMAEQVAEYLDIDDVPAAVEHLHIHASVIE
>NC_016111.1|WP_014141324.1|649779_650193_-|hypothetical-protein
MTHTCARCGAPSAVQWLRRPTPGEHTAINATAAQRRAEILELADPDRPPPIGPGLTEATDHTVAVYACSTHTITLDLATRIHASTCTAPHESDLPQCDCTPEPPPKPQPRPGDPGTMVTLPTGWVVPAPAERAPSGP

Crispr_ID: NC_016111_2

• CRISPR_ID: NC_016111_2
• CRISPR_location: 1576862-1576958
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_016111_2

Consensus_repeat	Method
CCCCGTCTCGTCGTGGCTGGCGTCAC	CRISPRCasFinder

spacers of NC_016111_2

>2.1|1576888|45|NC_016111|CRISPRCasFinder
GCTCGCGCTGGCGGTCAGCCATTACCTCCCCGGGGTTCGCCCGGT

CRISPR arrays and Neighbor proteins around NC_016111_2

CRISPR arrays

The CRISPR arrays of NC_016111_2

>merge|NC_016111|2|1576862-1576958|CRISPRCasFinder
CCCCGTCTCGTCGTGGCTGGCGTCACGCTCGCGCTGGCGGTCAGCCATTACCTCCCCGGGGTTCGCCCGGTCCCCGTCTCGTCGTGGCTGGCGTCAC

>NC_016111|2|2|1576862-1576958|CRISPRCasFinder
CCCCGTCTCGTCGTGGCTGGCGTCAC	GCTCGCGCTGGCGGTCAGCCATTACCTCCCCGGGGTTCGCCCGGT
CCCCGTCTCGTCGTGGCTGGCGTCAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016111.1|WP_014142215.1|1578501_1579284_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|377092
NC_016111.1|WP_014142206.1|1569134_1571372_-|MFS-transporter	unknown	unknown	gnl|CDD|341045
NC_016111.1|WP_014142210.1|1573289_1574108_+|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|187639
NC_016111.1|WP_014142213.1|1576006_1576774_+|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|131480
NC_016111.1|WP_014142207.1|1571461_1572037_+|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_014142204.1|1567442_1567772_-|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_014142219.1|1582370_1583267_-|polysaccharide-deacetylase-family-protein	unknown	unknown	gnl|CDD|213022
NC_016111.1|WP_014142203.1|1565936_1567385_+|glycine-betaine/L-proline-transporter-ProP	unknown	unknown	gnl|CDD|182611
NC_016111.1|WP_014142222.1|1585909_1586677_+|DUF4097-family-beta-strand-repeat-protein	unknown	unknown	gnl|CDD|372574
NC_016111.1|WP_014142217.1|1580045_1580705_+|VTT-domain-containing-protein	unknown	unknown	gnl|CDD|223659
NC_016111.1|WP_014142205.1|1567951_1569106_+|acyltransferase	unknown	unknown	gnl|CDD|224748
NC_016111.1|WP_014142216.1|1579420_1579873_+|DoxX-family-protein	unknown	unknown	gnl|CDD|225168
NC_016111.1|WP_014142214.1|1577668_1578253_-|TMEM165/GDT1-family-protein	unknown	unknown	gnl|CDD|225030
NC_016111.1|WP_014142224.1|1588037_1588262_+|zinc-ribbon-domain-containing-protein	unknown	unknown	gnl|CDD|274226
NC_016111.1|WP_014142208.1|1572191_1572860_+|HAD-IA-family-hydrolase	unknown	unknown	gnl|CDD|319829
NC_016111.1|WP_014142212.1|1575052_1575952_+|aldo/keto-reductase	unknown	unknown	gnl|CDD|381314
NC_016111.1|WP_014142218.1|1580793_1581549_-|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_014142223.1|1586748_1587993_+|hypothetical-protein	unknown	unknown	gnl|CDD|274008
NC_016111.1|WP_014142211.1|1574176_1575043_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|375319
NC_016111.1|WP_014142220.1|1583304_1585455_-|aminodeoxychorismate-synthase-component-I	unknown	unknown	gnl|CDD|223225

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016111.1|WP_014142215.1|1578501_1579284_-|ABC-transporter-permease	gnl|CDD|377092	pfam03649, UPF0014, Uncharacterized protein family (UPF0014).	2.46281e-42
NC_016111.1|WP_014142206.1|1569134_1571372_-|MFS-transporter	gnl|CDD|341045	cd17502, MFS_Azr1_MDR_like, Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.45281e-79
NC_016111.1|WP_014142210.1|1573289_1574108_+|SDR-family-NAD(P)-dependent-oxidoreductase	gnl|CDD|187639	cd08934, CAD_SDR_c, clavulanic acid dehydrogenase (CAD), classical (c) SDR. CAD catalyzes the NADP-dependent reduction of clavulanate-9-aldehyde to clavulanic acid, a beta-lactamase inhibitor. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	3.47816e-91
NC_016111.1|WP_014142213.1|1576006_1576774_+|alpha/beta-fold-hydrolase	gnl|CDD|131480	TIGR02427, b-ketoadipate_enol-lactone_hydrolase, 3-oxoadipate enol-lactonase. Members of this family are 3-oxoadipate enol-lactonase. Note that the substrate is known as 3-oxoadipate enol-lactone, 2-oxo-2,3-dihydrofuran-5-acetate, 4,5-Dihydro-5-oxofuran-2-acetate, and 5-oxo-4,5-dihydrofuran-2-acetate. The enzyme the catalyzes the fourth step in the protocatechuate degradation to beta-ketoadipate and then to succinyl-CoA and acetyl-CoA. 4-hydroxybenzoate, 3-hydroxybenzoate, and vanillate all can be converted in one step to protocatechuate. This enzyme also acts in catechol degradation. In genomes that catabolize both catechol and protocatechuate, two forms of this enzyme may be found. All members of the seed alignment for this model were chosen from within protocatechuate degradation operons of at least three genes of the pathway, from genomes with the complete pathway through beta-ketoadipate. [Energy metabolism, Other].	3.95872e-26
NC_016111.1|WP_014142217.1|1580045_1580705_+|VTT-domain-containing-protein	gnl|CDD|223659	COG0586, DedA, Uncharacterized membrane-associated protein [Function unknown].	4.19854e-15
NC_016111.1|WP_014142219.1|1582370_1583267_-|polysaccharide-deacetylase-family-protein	gnl|CDD|213022	cd10917, CE4_NodB_like_6s_7s, Catalytic NodB homology domain of rhizobial NodB-like proteins. This family belongs to the large and functionally diverse carbohydrate esterase 4 (CE4) superfamily, whose members show strong sequence similarity with some variability due to their distinct carbohydrate substrates. It includes many rhizobial NodB chitooligosaccharide N-deacetylase (EC 3.5.1.-)-like proteins, mainly from bacteria and eukaryotes, such as chitin deacetylases (EC 3.5.1.41), bacterial peptidoglycan N-acetylglucosamine deacetylases (EC 3.5.1.-), and acetylxylan esterases (EC 3.1.1.72), which catalyze the N- or O-deacetylation of substrates such as acetylated chitin, peptidoglycan, and acetylated xylan. All members of this family contain a catalytic NodB homology domain with the same overall topology and a deformed (beta/alpha)8 barrel fold with 6- or 7 strands. Their catalytic activity is dependent on the presence of a divalent cation, preferably cobalt or zinc, and they employ a conserved His-His-Asp zinc-binding triad closely associated with the conserved catalytic base (aspartic acid) and acid (histidine) to carry out acid/base catalysis. Several family members show diversity both in metal ion specificities and in the residues that coordinate the metal.	8.27664e-29
NC_016111.1|WP_014142203.1|1565936_1567385_+|glycine-betaine/L-proline-transporter-ProP	gnl|CDD|182611	PRK10642, PRK10642, proline/glycine betaine transporter ProP.	0
NC_016111.1|WP_014142222.1|1585909_1586677_+|DUF4097-family-beta-strand-repeat-protein	gnl|CDD|372574	pfam13349, DUF4097, Putative adhesin. This has a putative all-beta structure with a twenty-residue repeat with a highly conserved repeating GD, gly-asp, motif. It may form part of a bacterial adhesin.	8.08341e-09
NC_016111.1|WP_014142205.1|1567951_1569106_+|acyltransferase	gnl|CDD|224748	COG1835, COG1835, Predicted acyltransferases [Lipid metabolism].	1.24802e-26
NC_016111.1|WP_014142216.1|1579420_1579873_+|DoxX-family-protein	gnl|CDD|225168	COG2259, COG2259, Predicted membrane protein [Function unknown].	1.51193e-11
NC_016111.1|WP_014142214.1|1577668_1578253_-|TMEM165/GDT1-family-protein	gnl|CDD|225030	COG2119, COG2119, Predicted membrane protein [Function unknown].	7.02347e-25
NC_016111.1|WP_014142224.1|1588037_1588262_+|zinc-ribbon-domain-containing-protein	gnl|CDD|274226	TIGR02605, CxxC_CxxC_SSSS, putative regulatory protein, FmdB family. This model represents a region of about 50 amino acids found in a number of small proteins in a wide range of bacteria. The region begins usually with the initiator Met and contains two CxxC motifs separated by 17 amino acids. One member of this family is has been noted as a putative regulatory protein, designated FmdB (SP:Q50229, ). Most members of this family have a C-terminal region containing highly degenerate sequence, such as SSTSESTKSSGSSGSSGSSESKASGSTEKSTSSTTAAAAV in Mycobacterium tuberculosis and VAVGGSAPAPSPAPRAGGGGGGCCGGGCCG in Streptomyces avermitilis. These low complexity regions, which are not included in the model, resemble low-complexity C-terminal regions of some heterocycle-containing bacteriocin precursors. [Regulatory functions, DNA interactions].	3.32387e-11
NC_016111.1|WP_014142208.1|1572191_1572860_+|HAD-IA-family-hydrolase	gnl|CDD|319829	cd07527, HAD_ScGPP-like, subfamily of beta-phosphoglucomutase-like family, similar to Saccharomyces cerevisiae DL-glycerol-3-phosphate phosphatase (GPP1p/ Rhr2p and GPP2p/HOR2p) and 2-deoxyglucose-6-phosphate phosphatase (DOG1p and DOG2p). This subfamily includes Saccharomyces cerevisiae DL-glycerol-3-phosphate phosphatase (GPP1p/ Rhr2p and GPP2p/HOR2p) and 2-deoxyglucose-6-phosphate phosphatase (DOG1p and DOG2p). GPP1p and GPP2p are involved in glycerol biosynthesis, GPP1 is induced in response to both anaerobic and hyperosmotic stress, GPP2 is induced in response to hyperosmotic or oxidative stress, and during diauxic shift; overexpression of DOG1 or DOG2 confers 2-deoxyglucose resistance. These belong to the beta-phosphoglucomutase-like family whose other members include Lactococcus lactis beta-PGM, a mutase which catalyzes the interconversion of beta-D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), and Escherichia coli 6-phosphogluconate phosphatase YieH. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.68817e-67
NC_016111.1|WP_014142212.1|1575052_1575952_+|aldo/keto-reductase	gnl|CDD|381314	cd19088, AKR_AKR13B1, AKR13B family of aldo-keto reductase (AKR). Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.	7.61022e-138
NC_016111.1|WP_014142223.1|1586748_1587993_+|hypothetical-protein	gnl|CDD|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.00103495
NC_016111.1|WP_014142211.1|1574176_1575043_+|helix-turn-helix-domain-containing-protein	gnl|CDD|375319	pfam17765, MLTR_LBD, MmyB-like transcription regulator ligand binding domain. This domain is found in a family of actinobacterial transcription factors. The structure shows it has a PAS domain like fold and it is bound to Myristic acid.	1.04718e-54
NC_016111.1|WP_014142220.1|1583304_1585455_-|aminodeoxychorismate-synthase-component-I	gnl|CDD|223225	COG0147, TrpE, Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism].	4.66237e-136

Protein sequences

>NC_016111.1|WP_014142213.1|1576006_1576774_+|alpha/beta-fold-hydrolase
MLLPFDEAGQGQPVVLLHARPTDRTMWRAHLPLLAEAGVRAIALDLPGHGDSPLPDHREVAPWADVLDTLDHLGVDRFVLAGNSLGALVALQTAVTAPERVRGLALIGYRPHDLPPSPRLQTAWDREKTALDADDIEAAVQAGVDSWTSPNASDEVRAHAADMLRRQLTSQLAHGEPNLATDPLSQNADALRTLAIPALVGVGELDMPDFFQGGKSLADELDAGDLVVVPNAGHLAPLEQPEAFCALLLNAFRSR
>NC_016111.1|WP_014142212.1|1575052_1575952_+|aldo/keto-reductase
MTTSLADSVGTFEIAGKKVARLGFGAMRLTGLGVWGEPDDRGECVRVVRRAVELGVQLIDTADSYGPYVSEEIIREAIHPYSDDVLIATKAGLTRNGPDVIRRGGELVRLGPAAWPPVGRPEYLRQQALMSLRRLGLDHIDLFQLHRVDPKVPLEDQVGELKKLQDEGKIVAIGLSQVTVDQIERARRVADIATVQNRYNLTDRTSADVLAYCTRHGIGFIPWAPVAAGELARPGGTADRIASAHGTRPSHVALSWLLASSEVMLPIPGTSKVAHLEDNVAAAHLRLSEAEIAELDAAA
>NC_016111.1|WP_014142211.1|1574176_1575043_+|helix-turn-helix-domain-containing-protein
MDSKNELGDYLRARRALIRPEDVGLPDYGPRRVPGLRRDEVALLVGVSTDYYIRLEQGRERHPSDQVLRAIAGALRLDDAAAAHLYRLGMPVFGTKTSTSTTVAPELLRLMEGMQDVPAFLVGAAQDVLAANAMARELYCGFARYDNLLRMIFLDPYAKEFYADWEAAARIAVGNLRASSSQFPEDERIQRVVGELTLRSPAFTNLWARYEVRPRTHEDKHFRHPRVGELRLHFEALAVASAPGQHLSVYSAEPGSASADALVLLRRLAEQSATAADPSNEDIPIQKE
>NC_016111.1|WP_014142210.1|1573289_1574108_+|SDR-family-NAD(P)-dependent-oxidoreductase
MTSYPDTADLAPETHRASALRPLAGTVALVTGASSGIGEGTALALAALGASVTVAARRTGRLDALVETIEGTGGRALAVTADITDERQADATVARAVETFGRLDVVVANAGVMLLGPLAGADTTEWRRMIELNTLGLMYTAHAAVPHLLDSAAHGPRQVADLVLVSSTAGRQVRDGSGAYNASKYAVTAFGEALRRELTRRHVRTSLVEPGAVETELPEHNRPEIQQRMRERYSTMERLTPADVADAIAFVVTRPRHTAVNEILIRPTEQQD
>NC_016111.1|WP_014142208.1|1572191_1572860_+|HAD-IA-family-hydrolase
MTRRSQTLGVFKAALLDMDGTLVNSDAVVERCWRRWADEHGLDPAEVLKVVHGRQGYATMAVLLPERPMAENHADNARMLAEETADVDGVVPVPGAPEFLAALAGLPHALVTSADEALARARMDAAALPMPEVRVTAESVSASKPDPEGFLKGAAELGFAPEECVVFEDSEAGISAGLAAGMTVIGVGPRAAALSPTAHVPTLEQVAVSPAAEGGFTLALLS
>NC_016111.1|WP_014142207.1|1571461_1572037_+|hypothetical-protein
MATEFGPRGLQLVLLRRMADHRPELVEEALRELGASRSEMREANRHWQATLRARTFPRGEARHRLLLGAPESVAERRIGDVTCRALRWPVPLWPGLRFEVMSGPGGRVWNEWLVRAPGATPPAPREVADLRPWSYVVDEVARAFPAARPLEGDAPTRWRLAFADPGTGERHVAHFTYGLLQTVEPQVGGVG
>NC_016111.1|WP_014142206.1|1569134_1571372_-|MFS-transporter
MANGHPGEPLILDRGAAMARDDAIRPEGTAPGSPGGSVPDHPDRPASGVPAGRPPTGAGTAEPSGPGNVPGDVPGDTPRRIVLVAMSALLMGMLLAALDQTIVSTALPTIVSDLGGLNHLSWVVTAYLLASTAATPLWGKLGDQYGRKRLFQTAIVIFLIGSALCGIAQNMGELIVFRALQGLGGGGLMVLSMAIVGDIVPPRDRGRYQGLFGAVFGASSVLGPLLGGLFVDHLSWRWVFYINLPIGVVALGVIAAVLHIPVHRTKHTIDYAGTAAIAAVATCLVLVASLGGTTWPWASWQIVVLAVAGVVLLALFVAIERRAAEPVLPLRLFRLRAFTLCSVIGFIVGFAMFGAMTYLPTFLQVVHGISPTLSGVHMLPMVLGMLISSTGSGQIVSRTGRYKVFPVLGTGITIGGLYFLHTLDEFTGTWTMSAAFFVFGFGLGLVMQVLVLVVQNAVGYADLGVATSGATFFRSIGASFGVAIFGTVFSSELRTQLTGALAGRALPPGLTPQALQSDPHTVAALPPAVRGAVLHSYAVAITDVFLYAMPVAAVAFALAWFLREQPLRASVTAPDVSETYASNPVERSSRDEVARALSWLGTREGRRGLYRRITELAGLDLHPAASWLLLRINRYGSAAPQLLGERTDVPPEVVYQASAELEIAHLVRREGLVLVLTDAGREVAGRLVDVRTSVLAELLGDWWDPKRARDDLHGLLRELSGQLCGDDSDRPMPRQAPPRRAAATT
>NC_016111.1|WP_014142205.1|1567951_1569106_+|acyltransferase
MGTAMPVHDSPPLPPVAVTAATPSAAAPTGPGRRPRLYVLDGLRLLAALYVVAYHYTAFAEHDPHPWGRPVHEVFPVFNRFSSYGFLGVQLFFLISGFVICMTAWGRTPKDFLISRVTRLFPAYWFAIAATTVFVLLAGGHWLRYGRGIDQFLTNLTMLQDPLKVSDVDGVYWTLWCELVFYLLFLVVVRAGLSYQRVVSFCGIWLVAGVISTGSGDSIVRTLTMPGQAPYFAGGVAIYLMHRYGPDLLLAGLTGLCWLLSLHQLATQLPEVSGHVGHHLQFGYAAAFVTACYAVLIAAALGRLDWIRWRGLTTLGALTYPLYLLHEDIGWGVILHLHDTVPAWALVGGVTAFFLYAAWLVHRYVERPLARYLKRGLSKPRPAR
>NC_016111.1|WP_014142204.1|1567442_1567772_-|hypothetical-protein
MNEHDGHAAPDSGSGPRRVLDEVRAAETERRTRQALDDFADHPRRAVQELDTLLAEACGWFTDALTDRRHALRQHWRGEGGSASTTVGPDDLRHALAEYRDLLLRLSRL
>NC_016111.1|WP_014142203.1|1565936_1567385_+|glycine-betaine/L-proline-transporter-ProP
MTTHPDTLKAETRWPPNRGVGGTADRARPVTVVDQKMVKRAVTAAALGNAMEWFDFGVYSYIAVTLGEVFFPSGNPTAQLLSTFGAFAAAFLVRPVGGMVFGPLGDRIGRQKVLAITMIMMAVGTFAIGLIPSYAAIGVGAPLLLLAARLVQGFSTGGEYGGASTFIAEYAPDKRRGFLGSWLEFGTLVGYVAGASIVAVLTAVLSHDALLAWGWRIPFLVAGPLGLIGLYLRLKLEETPAFARLEQEARAKQVEQSAKKSLREILLGQWRAMLLCVALVLVFNVTDYMLLSYMPSYLTGQLHYGATHGLIVVLVVMVVMMAVQPLAGRLSDRFGRRPVIGAGCAGFLLLSIPALLLIRQGSLAGVYAGMAALGLLLVCFTGAMPSTLPALFPTRIRYGALSVGFNISVSLFGGTTPLVVTALISATGNLLMPAYYMMAAAVVGGVAVLLMSETAGRPLKGSPPAVATEAEARELAATPQAA
>NC_016111.1|WP_014142214.1|1577668_1578253_-|TMEM165/GDT1-family-protein
MFSLTIAAIVFGVIFVAELPDKTALASLMLGTRYRAGYVFCGIAAAFAVHVVVAIAAGSLLTLLPHRWVQGVVGVLFLAGAAMILWQHSGDEDEETMKPPADQSFWKVAGSGFMLILVAEFGDLTQIMTANLAARYGDPLSVGIGAVLALWAVAGIGILGGRALMKRVPLRLITKIAAAVMVALAGFSLYEALS
>NC_016111.1|WP_014142215.1|1578501_1579284_-|ABC-transporter-permease
MAVSAAASATTLLPVNAMLGVVLAALLLAAVAVACYARFVDDRENYPRAIAYAGLRAVVQLAVVALVIGWVVRRLPTLLAFVLVMYAVAVRTAGRRITRNGTWWWASVPIAVGALPVVALLVAVGLVPLKGVALIPVAGILIGGALTATVLAGQRALDELRSRHGEVEAALALGLLERDARLEIARPAAATALIPGLDQTRTVGLVTLPGAFVGMLIGGASPVMAGAVQLFVLVALLAVQAVAVTVVLELVARGRITRPR
>NC_016111.1|WP_014142216.1|1579420_1579873_+|DoxX-family-protein
MRLSADTAKPHVLALFRVVTGLLFACHGAASLFGVLGGAAGTHGGTLPAGAWPGWYAAVIQFIGGVLVVLGLGTRAAALISSGSMAYAYFSVHAKLALWPLQNGGEPAALYSWAFLLLAVTGPGAWALDGIFSAARRRRPAAPAEAGSPA
>NC_016111.1|WP_014142217.1|1580045_1580705_+|VTT-domain-containing-protein
MVDRLTALVDSPWAFALVALSVLLDVFLPVLPSGVLLTSAATVGTAGADGAKDATDIVALLLCASAASCLGDLAAYRLAWRGGAWLDRRLERSRRLAAAQERLGQVLTQGGGALVVLARFAPAGRSVVSLGAGAAHRRPAEFLPWSALAGFVWAAYGVGLGYIGGHWLGASWVSTAMSLLALAGAGAVAAYVFRRERRTLATPDLPVPAQDLPVPADLR
>NC_016111.1|WP_014142218.1|1580793_1581549_-|hypothetical-protein
MDDTREHVERLLDRAHNAFELDDAVVARLRGALMHCVELHSLHRRNGPPYPLGHRTLRHVFLLPDGADLVLWEIEYTTGPGSRTLHEVYADQAQAAEAERRMTAWCGTEPYPRADTDADAALQDLLSGILDDLAIPGRSRSRHTYEHDRSAEHAWRVLRRAENPDRPGARIRRLLRTAVGHETTLVAMRHARDEGPAVEWALYEHAFLLADDSELSLWEVEHFPPDGYPVCEVYLDETTARDSAERRREAL
>NC_016111.1|WP_014142219.1|1582370_1583267_-|polysaccharide-deacetylase-family-protein
MKRHNGLSRVHSTTAGVAALAAVATLATGCGGGADAAGKPSPAPTASGAPASGTPSAPAGGDGTASVPAAVWHKWGLKPLPAPPAPPADKPVKLTAHGPVPVFAHIPTHQKVVFVTLDDGQEKDPKFIAMMRELRIPVTMFLMNDAIKSDYGYFKPLQALGNHIQNHTLHHPAMNTIPLARQTEEVCGDQKILTKQYGTAPLLFRPPYGAYDTATKAAVNACGPRAIVWWRESMQITNMQYQAPDKKLRPGDIILAHFRGPSELKGTTMTEMFANLIRRIEEQGFTVARLEDYVAAPS
>NC_016111.1|WP_014142220.1|1583304_1585455_-|aminodeoxychorismate-synthase-component-I
MRTLLIDNYDSFTYNLVHQIAAATGQEPEVVRNDDPGWRAGRLDGYDAVVISPGPGTPRRTSDFGICDEVIARCERARLPLLGICLGHQGIAARHGGTVERAPEPRHGRTSPVLHDGTGLFAGVPSPFEVVRYHSLAVTDLPDELRATAWTEDGVLMALAHRERPVWGLQFHPESICTRHGDLLLRNFTALARAERAAHPRPPVTVRAPEPTPAPAAPPRELEVLAERIPTRWDAEVVFDRLFRERPYAYWLDGGGPGSGLSADGTGRFSVLGDATGPLARVATADVWTGTVTVRERGREQLVTGSFLDWLDADLRGLRTTCPELPCDFALGWVGYLGYELKAECGGERAHRSPDPDAVLVFTDRAIVLDHATGTTYLLALAERGARSQARAWLRETRRRLAALAGAAPGPAPRPQPAAHGIRLRHDRARYLELIAEAQEEIAAGETYEVCLTNTADIPGPVDAWQAYRLLRRLSPAPFGALLSFGGLSVLSTSPERFLRIGADGVAESRPIKGTRPRGATAAEDEALRAGLAADEKDRSENLMIVDLVRNDLGRCAVTGSVVADDVFRVESFRTVHQLVSTVRARLRPGASAVDCVRSAFPGGSMTGAPKVRTMRIIDRLEGGPRGVYSGVIGYFSLTGAADLSIVIRTAVVTERGIRYGTGGAIVALSDPAAEFEETAVKAAPLLALTATEFPGRADAGAPGAGQGTDPAVSRS
>NC_016111.1|WP_014142222.1|1585909_1586677_+|DUF4097-family-beta-strand-repeat-protein
MASAHRIRMGFRAPLLATVLGLALAGCGHAVADRGPAEHRSFAFTGKRLTIETTEGSLVVEAADVRKVEVTRWFRGRAVLGVTPRATWDLTGATLALRTHCAGVVSSCSIRHKVLVPRGLAVAVRAGDGKVEAEDIGTPLNISTANGSVQVKDCSGDLTLTSHNGKVTATGTGARTVRARSGNGSVQLGFATVPDRVDVTSGNGKVTVELPPASYDVTARSSNGSTHVDVPVKRHSGHVVTVRVKNGSATVRTAT
>NC_016111.1|WP_014142223.1|1586748_1587993_+|hypothetical-protein
MATARSWWRRDDDSHRAAARSAKDAAAESFYELDTAQRELTLTIETITAVDRSPGGRKAKADYDSLARRIDEVSGGYIAAVDAHDLDAEQLDLAAATRARNAFTLARDEIVKVRADLDRFARSLGPMLTRAENELSRLAPAVEQARQALLGATGALDEVRAAGLRADDLAARLAALGPELTKLNAGAKAHGVRETIQRADAMRRAAGEIRAEAEALPQRAAEIDRRLVSLRTRAQALTTRAGQVGPTLSELRRRFSAACWQDLQQVPERAADAVARAERRLAEAERARAEQRWPDATAALTAVRDLLAETDAAVSAAGDRLRRLDEVSRDPQGEIERTRFALRDAQRLAMQGRATPDPRHAGPLDDGVARLQRAVDGLTGRHPDYWAFLTELAAIRETAEDVVAAIREERARTS
>NC_016111.1|WP_014142224.1|1588037_1588262_+|zinc-ribbon-domain-containing-protein
MPRYEYRCRACGTTFEMNRPMAQSSDPAACPHGHDDTVKLLSTVAVTGTATSGAGAARAPQGGGGGCCGGGCCG

Crispr_ID: NC_016111_3

• CRISPR_ID: NC_016111_3
• CRISPR_location: 1727417-1727503
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_016111_3

Consensus_repeat	Method
CCGCGCTACGCCTCGACCGCCCCCGCG	CRISPRCasFinder

spacers of NC_016111_3

>3.1|1727444|33|NC_016111|CRISPRCasFinder
GCCCCCACCTCCCGGGGGACGACCCCCGTACCC

CRISPR arrays and Neighbor proteins around NC_016111_3

CRISPR arrays

The CRISPR arrays of NC_016111_3

>merge|NC_016111|3|1727417-1727503|CRISPRCasFinder
CCGCGCTACGCCTCGACCGCCCCCGCGGCCCCCACCTCCCGGGGGACGACCCCCGTACCCCCGCGCTACGCCTCGACCGCCCCCGCG

>NC_016111|3|3|1727417-1727503|CRISPRCasFinder
CCGCGCTACGCCTCGACCGCCCCCGCG	GCCCCCACCTCCCGGGGGACGACCCCCGTACCC
CCGCGCTACGCCTCGACCGCCCCCGCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016111.1|WP_014142363.1|1732909_1733845_-|NADP-dependent-oxidoreductase	unknown	unknown	gnl|CDD|176191
NC_016111.1|WP_014142361.1|1730166_1732035_-|elongation-factor-4	unknown	unknown	gnl|CDD|235462
NC_016111.1|WP_014142356.1|1724512_1725229_+|MBL-fold-metallo-hydrolase	unknown	unknown	gnl|CDD|293840
NC_016111.1|WP_014142368.1|1737095_1739600_-|ComEC/Rec2-family-competence-protein	unknown	unknown	gnl|CDD|225212
NC_016111.1|WP_014142354.1|1722129_1723272_-|molecular-chaperone-DnaJ	unknown	unknown	gnl|CDD|237654
NC_016111.1|WP_014627646.1|1729566_1729971_-|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_014627645.1|1726110_1727343_-|coproporphyrinogen-III-oxidase	unknown	unknown	gnl|CDD|180172
NC_016111.1|WP_014142367.1|1736589_1737048_+|pyridoxamine-5'-phosphate-oxidase	unknown	unknown	gnl|CDD|132706
NC_016111.1|WP_014142364.1|1734034_1734628_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|366102
NC_016111.1|WP_041825034.1|1735726_1735972_+|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_014142357.1|1725269_1726100_+|DUF3097-domain-containing-protein	unknown	unknown	gnl|CDD|378628
NC_016111.1|WP_014142350.1|1716414_1716774_-|histidine-triad-nucleotide-binding-protein	unknown	unknown	gnl|CDD|238607
NC_016111.1|WP_014142355.1|1723272_1724292_-|heat-inducible-transcriptional-repressor-HrcA	unknown	unknown	gnl|CDD|234621
NC_016111.1|WP_014142349.1|1715493_1716393_-|ribonuclease-Z	unknown	unknown	gnl|CDD|234602
NC_016111.1|WP_014142369.1|1739596_1740229_-|ComEA-family-DNA-binding-protein	unknown	unknown	gnl|CDD|224472
NC_016111.1|WP_014142353.1|1720997_1722065_-|nitronate-monooxygenase	unknown	unknown	gnl|CDD|367316
NC_016111.1|WP_014142365.1|1734662_1735652_-|DNA-polymerase-III-subunit-delta	unknown	unknown	gnl|CDD|236130
NC_016111.1|WP_014142352.1|1720245_1721001_-|16S-rRNA-(uracil(1498)-N(3))-methyltransferase	unknown	unknown	gnl|CDD|236959
NC_016111.1|WP_014142351.1|1716907_1720171_-|S41-family-peptidase	unknown	unknown	gnl|CDD|227282
NC_016111.1|WP_014142362.1|1732320_1732587_+|30S-ribosomal-protein-S20	unknown	unknown	gnl|CDD|376586

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016111.1|WP_014142363.1|1732909_1733845_-|NADP-dependent-oxidoreductase	gnl|CDD|176191	cd05289, MDR_like_2, alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases. Members identified as zinc-dependent alcohol dehydrogenases and quinone oxidoreductase. QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR actin the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	7.12095e-74
NC_016111.1|WP_014142361.1|1730166_1732035_-|elongation-factor-4	gnl|CDD|235462	PRK05433, PRK05433, GTP-binding protein LepA; Provisional.	0
NC_016111.1|WP_014142356.1|1724512_1725229_+|MBL-fold-metallo-hydrolase	gnl|CDD|293840	cd16282, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily.Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	1.46834e-47
NC_016111.1|WP_014142368.1|1737095_1739600_-|ComEC/Rec2-family-competence-protein	gnl|CDD|225212	COG2333, ComEC, Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only].	1.28429e-52
NC_016111.1|WP_014142354.1|1722129_1723272_-|molecular-chaperone-DnaJ	gnl|CDD|237654	PRK14278, PRK14278, chaperone protein DnaJ; Provisional.	0
NC_016111.1|WP_014627645.1|1726110_1727343_-|coproporphyrinogen-III-oxidase	gnl|CDD|180172	PRK05628, PRK05628, coproporphyrinogen III oxidase; Validated.	0
NC_016111.1|WP_014142367.1|1736589_1737048_+|pyridoxamine-5'-phosphate-oxidase	gnl|CDD|132706	TIGR03667, Rv3369, PPOX class probable F420-dependent enzyme, Rv3369 family. A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomycetales, make F420. A variant of the Partial Phylogenetic Profiling algorithm, SIMBAL, shows that this protein likely binds F420 in a cleft similar to that in which the homologous enzyme pyridoxamine phosphate oxidase (PPOX) binds FMN. [Unknown function, Enzymes of unknown specificity].	1.56254e-05
NC_016111.1|WP_014142364.1|1734034_1734628_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	2.67455e-12
NC_016111.1|WP_014142357.1|1725269_1726100_+|DUF3097-domain-containing-protein	gnl|CDD|378628	pfam11296, DUF3097, Protein of unknown function (DUF3097). This family of proteins with unknown function appears to be restricted to Actinobacteria.	9.35754e-161
NC_016111.1|WP_014142350.1|1716414_1716774_-|histidine-triad-nucleotide-binding-protein	gnl|CDD|238607	cd01276, PKCI_related, Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a hydrophobic residue) that is a signature for this family. No enzymatic activity has been reported however, for PKCI and its related members.	1.06201e-51
NC_016111.1|WP_014142355.1|1723272_1724292_-|heat-inducible-transcriptional-repressor-HrcA	gnl|CDD|234621	PRK00082, hrcA, heat-inducible transcription repressor; Provisional.	3.60403e-157
NC_016111.1|WP_014142349.1|1715493_1716393_-|ribonuclease-Z	gnl|CDD|234602	PRK00055, PRK00055, ribonuclease Z; Reviewed.	2.59147e-114
NC_016111.1|WP_014142369.1|1739596_1740229_-|ComEA-family-DNA-binding-protein	gnl|CDD|224472	COG1555, ComEA, DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair].	2.04343e-22
NC_016111.1|WP_014142353.1|1720997_1722065_-|nitronate-monooxygenase	gnl|CDD|367316	pfam03060, NMO, Nitronate monooxygenase. Nitronate monooxygenase (NMO), formerly referred to as 2-nitropropane dioxygenase (NPD) (EC:1.13.11.32), is an FMN-dependent enzyme that uses molecular oxygen to oxidize (anionic) alkyl nitronates and, in the case of the enzyme from Neurospora crassa, (neutral) nitroalkanes to the corresponding carbonyl compounds and nitrite. Previously classified as 2-nitropropane dioxygenase, but it is now recognized that this was the result of the slow ionization of nitroalkanes to their nitronate (anionic) forms. The enzymes from the fungus Neurospora crassa and the yeast Williopsis saturnus var. mrakii (formerly classified as Hansenula mrakii) contain non-covalently bound FMN as the cofactor. Active towards linear alkyl nitronates of lengths between 2 and 6 carbon atoms and, with lower activity, towards propyl-2-nitronate. The enzyme from N. crassa can also utilize neutral nitroalkanes, but with lower activity. One atom of oxygen is incorporated into the carbonyl group of the aldehyde product. The reaction appears to involve the formation of an enzyme-bound nitronate radical and an a-peroxynitroethane species, which then decomposes, either in the active site of the enzyme or after release, to acetaldehyde and nitrite.	1.19041e-94
NC_016111.1|WP_014142365.1|1734662_1735652_-|DNA-polymerase-III-subunit-delta	gnl|CDD|236130	PRK07914, PRK07914, hypothetical protein; Reviewed.	5.12027e-87
NC_016111.1|WP_014142352.1|1720245_1721001_-|16S-rRNA-(uracil(1498)-N(3))-methyltransferase	gnl|CDD|236959	PRK11713, PRK11713, 16S ribosomal RNA methyltransferase RsmE; Provisional.	1.54995e-71
NC_016111.1|WP_014142351.1|1716907_1720171_-|S41-family-peptidase	gnl|CDD|227282	COG4946, COG4946, Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown].	1.27342e-113
NC_016111.1|WP_014142362.1|1732320_1732587_+|30S-ribosomal-protein-S20	gnl|CDD|376586	pfam01649, Ribosomal_S20p, Ribosomal protein S20. Bacterial ribosomal protein S20 interacts with 16S rRNA.	2.35707e-22

Protein sequences

>NC_016111.1|WP_014627645.1|1726110_1727343_-|coproporphyrinogen-III-oxidase
MPSVLPDGEPMPADGSLPGHALAGAAGRPLGFYLHVPYCATRCGYCDFNTYTASELRGSGGAPASRDNYAETLVEEVRLARKVLGDDPRQVATVFVGGGTPTLLAAEDLGRMLAAIRDEFGLAPGAEVTTEANPETVDPAYLERLRAAGFTRVSFGMQSARQHVLRILERTHTPGRPEKCVEQARAAGFDHVNLDLIYGTPGESDDDWRASLDAAIGAGPDHVSAYALIVEDGTRLAHRIRRGEIPMTDDDVHADRYLIAEQALSDAGFHWYEVSNWATTKAGRCRHNELYWRGADWWGAGPGAHSHVGGVRWWNVKHPGAYAQALAEGRTPGAGREVLTDEDRRVERVLLELRLADGCPLDLLRPDGARAAARALADGLLQPAPYQAGRAVLTLRGRLLADAVVRDLVD
>NC_016111.1|WP_014142357.1|1725269_1726100_+|DUF3097-domain-containing-protein
MRSRSYGPDLTPPWKRSKPAPEVAAEPDLVVEEVGTGFCGAVVRCEKTAEGVTVTLEDRFGKHRVFPLVPRGFMIDGQVVTLVRPAPAGRAPAGPRLTASGSIAVPGARARVARAGRIYVEGRHDAELVERVWGDDLRIEGVVVEYLEGVDDLPGIVAEFAPGPDARLGVLVDHLVPGSKESRIAERVGGPDVLVVGHPFVDVWQAVKPAAVGIPAWPTVPRGQDWKTGVCRALGWEEHTGAAWRRILASVRSYKDLEPELLGAVEHLIDHVTTPA
>NC_016111.1|WP_014142356.1|1724512_1725229_+|MBL-fold-metallo-hydrolase
MEKTERDGWERLAPGVARRRLAFLDVTIGVVVGTDGVLLIDSGSTVPEGERLRREVRDLTGRDVTHLALTHAHFDHVLGASAFPEAAVYGQAGLAGVLARGRAELGEDAVRYGVAGPEARRAVDALVTPGHPVDRRHALDLGGREALLVHPGPGHTGHDLAVVVPGTPVVVFCGDLVEESGEPQAGPDAVPGRWPAALDALLELGGETAVYVPGHGAVVDARFVRAQRDALARRFAVG
>NC_016111.1|WP_014142355.1|1723272_1724292_-|heat-inducible-transcriptional-repressor-HrcA
MLSERRLEVLRAIVQDYVGTEEPVGSKALTERHKLGVSPATVRNDMAVLEEEGFIQQPHTSAGRIPTDKGYRLFVDRLAGVKPLSAAERRAIQNFLDGAVDLDDVVARTVRLLAQLTRQVAVVQYPSLTRSTVRHVELLSLAPARVMLVLITDTGRVEQRLVDCPAPVGETVLADLRARLNSRVVGRRFTDVPSLVQDLPDSFEHDDRPTVSVVLATLLETLVEETEERIMLGGTANLTRFAHDFPLTIRPVLEALEEQVVLLKLLGEGAKDSGVTVRIGHENAHEGLNSTSVIAVGYGSGDEAVARLGVVGPTRMDYPGTMGAVRAVARYVGQILAES
>NC_016111.1|WP_014142354.1|1722129_1723272_-|molecular-chaperone-DnaJ
MATDYYAVLGVRRDAGQDEIKKAFRRLARELHPDVNPDPKTQERFKEINAAYEVLSDPQKKQIYDLGGDPLSASGGAGGAGAGGFGAGFGNFSDIMDAFFGTASQRGPRSRTRRGQDAMIRLEIELDEAAFGTTKEIQVDTAVTCTTCAGEGAAPGTAAQTCDMCRGRGEVSQVTRSFLGQVMTSRPCPQCQGFGTVVPTPCPECAGDGRIRSRRTLTVKIPAGVDNGTRIQLAGEGEVGPGGGPAGDLYVEIRELPHQVFQRRGDDLHCTVTIPMTAAALGTKVPLETLDGLEEVDIRPGTQSGQSIPLHQRGITHLRGGGRGDLVVHVEVQTPTKLDAEQEELLRRLAVLRGEERPSGHFQPGQQGLFSRLKDAFNGR
>NC_016111.1|WP_014142353.1|1720997_1722065_-|nitronate-monooxygenase
MPTLTELLPLPVVQAPMAGGASGPALAAVVSGAGGLGFLAAGYKTPEAVRREIAEVRALTARPFGVNVFLPQPAADPAAVAAYAARLAPEADRYGTALGDPGAGDDDAYDAKVALLLADPVPVVSFTFGCPEPAVVEALRRAGTYTVVTVTSAAEAVAARRAGADAVCAQGTEAGAHQGRHHDDPGRDATATTLQALLPAVREAAGLPVIAAGGIMDGRGIAAVLAAGAEAAQLGTAFLATAESGAHPLHKRALTDPGYDRTELTRAFSGRPARGLVNRFLREHGPAAPAAYPAVHHLTSPLRKAAAAAGDTEAMALWAGQGHRLARELPAAELVRVLAAELAEARGARTPGRAR
>NC_016111.1|WP_014142352.1|1720245_1721001_-|16S-rRNA-(uracil(1498)-N(3))-methyltransferase
MTAPVFVVPPGALPAAPGTRVVLDGPEGRHAVSVRRLRVGEEIVLTDGEGTGAYGTVAAVEGKDWLEAEVAEVRREPDPAPRITVVQALPKGDRGELAVETMTETGVDAVVPWAAGRCVTQWKGERGVKALAKWRATAREAGKQARRLRFPVVHDLMTTRQVAGLLAGADFAAVLHEEGAAPLAAAPLPKRGEIVLVVGPEGGVAPDELAAFADAGAAPCRLGPTVLRTSTAGVAATALLLGRTGRWGAPD
>NC_016111.1|WP_014142351.1|1716907_1720171_-|S41-family-peptidase
MTHPSYLRYPHPHGDLITFTAEDDVWAAPLDGGRAWRVSADNMPVDHPRISPDGEHIAYTSTRDGAPEVHFAPVDGGPAKRLTYWGSWQTRVLGWTPRGEVLAVTAHGEVSSRRTWARAVPLDGGPARTLPYGPVGGVAFGPDGAVLLQSVSMGREAATWKRYRGGTAGKLWLDPDGTGTFHRVHAALDGNIECPLWVSGGGGPARIAFLSDHEGTGALYSSLPDGSDLRRHTPLDGFYARHAATDGTRVAYTSGGRLHLLDSLDAEPRPLQVRLGGQRTDLQPYPVRAAHHLGDAHPDHTGRGSAVEVRGTVHWLTHREGPARALAATPGVRARLPRVFRKGGEGEPHVVWVTDAEGEDALEFAPATGSGAETGRTDATAPPHRLAAGRLGRVLELAVSPDGRRVAVASHDGRVLLVERETGEVRRVSDSEHGEASGLVFSPDSGWLAWSQPGPAPLRQLRLANTTTLAVCDATPLRFNDFSPAFTADGKHLAFLSERAFDPVYDAHVFDLSFPNACRPYLITLAADTPSPFGPQRHGRPLGGGADDRAEGERHDEGHPEDGERRVPVTRLDLDGLADRIVPFPVEAGRCSTLRAAAGGVLWLRHPLHGVLGAALATPQATPPATTLERFDLDRLRAEELAEDVDDFAVTGDGRRLLLTSGGKLRVVPSDAKADDEDGDSAVTVDLSRIRVTVEPAAEWRQMYAETGRLMRDNFWRPDLGGVDWDGVLDRYRPLLDRVATHDDLCDLLWEVHGELGTSHAYVVPPRGRGDALHRQGLLGADLVRDGDGVWRVARVLPSETSDPGARSPLAAPGVAVRAGDALLAVDGRPVDPVAGPGPLLVGTAGKPVELTVVGATGEPRAVVVVPIADEEPLRYHDWVAGRRAHVHERSAGRLGYLHVPDMQGYGWAQLHRDLRIEVAREGLVVDLRENRGGHTSQLVIEKLVRRVVGWDVPRGARPSSYPLDAPRGPVVAVADEFSGSDGDIVNAAIKELGIGPVVGTRTWGGVVGIDSRYHLVDGTLVTQPKYAIWFDSLGWDLENHGVDPDIEVVPTPQDRVAGRDVQLDTAIEVALERLAAQPARTPPALP
>NC_016111.1|WP_014142350.1|1716414_1716774_-|histidine-triad-nucleotide-binding-protein
MAGDPQADCLFCKIVAGDVPATIVHENDTTVAFRDINPQAPTHVLVIPKAHYPDAASLAEQAPQLAADVLATAGQVAAAERVDGTGYRIVFNTGGGAGQTVFHAHAHLLGGRGLNWPPG
>NC_016111.1|WP_014142349.1|1715493_1716393_-|ribonuclease-Z
MRELVVLGTASQVPTRHRNHNGYLLRWDGEGILFDPGEGTQRQMLLAGVAAHDLTRICVTHFHGDHSLGVAGVVQRINLDRVPHPVTAHYPASGSRFFERLRYATAYRQTAVIRQEPVIGDGELAVTPAFTLTARKLSHPVDSYGYRLVEPDGRRMLPEKLAAHGIAGPDVGRLQRDGELRGVRLEEVSEVRRGQRFAFVMDTRLCDNVHALADGCDLLVIESTFLGPDEALADEYGHLTAAQAARVAAGAGVRHLVLTHFSQRYPDPEAYAAEAREAGFTGELTIARDLDRVPFPKRR
>NC_016111.1|WP_014627646.1|1729566_1729971_-|hypothetical-protein
MSDSAMARRMLLAAAGSAVALGSACPAAMAASADAFDGRHLSANQGAGCASHTLALVGDHVLHHGRLPKVFNHYRGGGLPVDGVAALCEAVDEKEAKDGRQGPLGLLGGLPLHGNPLNAVHQLPVGASPLGHTG
>NC_016111.1|WP_014142361.1|1730166_1732035_-|elongation-factor-4
MPATPSHVPEPSRTDPALIRNFCIIAHIDHGKSTLADRMLQLTGVVEQRQMRAQYLDRMDIERERGITIKSQAVRLPWAPTSGEGKGTTHVLNMIDTPGHVDFTYEVSRSLAACEGTILLVDAAQGIEAQTLANLYLALENDLTIIPVLNKIDLPAAQPEKYAAELAHIIGCDPSEVLKVSAKTGEGVAELLDKVVAEVPAPVGVADAPARAMIFDSVYDSYRGVVTYVKVVDGRLSKRERIQMMSTGAAHELLEIGVSSPEMTAADGLGVGEVGYLITGVKDVRQSKVGDTVTRLHKGATEALGGYKDPKPMVFSGLYPLDGSDYPELRDALDKLQLNDAALVYEPETSAALGFGFRVGFLGLLHLDVIRERLEREFGLDLIATAPNVVYRVIMEDGSEHTVTNPSEFPVGKIDEVYEPVVRATVLAPSEFVGAIMELCQSRRGSLLGMDYLSEDRVELRYTLPLAEIVFDFFDQLKSKTRGYASLDYEPTGEQISDLVKVDILLHGDKVDAFSAILHKDKAYAYGVRMAGKLRELIPRQQFEVPIQAAIGSRVIARETVRAIRKDVLAKCYGGDISRKRKLLEKQKEGKKRMKMVGNVEVPQEAFIAALSTDEGDAKARK
>NC_016111.1|WP_014142362.1|1732320_1732587_+|30S-ribosomal-protein-S20
MANIKSQIKRNKTNEKARLRNKAVKSELKTAIRRTREAVEAGNAEKATEAARAAARKLDKAVSKGVIHKNQAANKKSALASSVASLKG
>NC_016111.1|WP_014142363.1|1732909_1733845_-|NADP-dependent-oxidoreductase
MNAIRFHEYGEATDVLRLERADVPVPGPGEIRVAVHACGLNPADWALCRGLFTGQLPRGIGLEVSGTVDAVGAGVTGVAVGDTVLGAADYAGGHSAGAADFAVLTHWAHVPEGLDLVQAAALPMAVETAYRSLEQLAVTAGRTLLVHGAGTMIGFAAVQIALDRGARVIAAAGPTYAERLRALGATVTSYGDGMAERVTAAAGGPVDLVLDTAPPGGVLPALVRVADGDPRRVLTVSDPDGVGLGVRTSFDEDASKALRYDVLGEFAQRAAEGRFSIPVARVFPLADWRTAAETSLGGRARGKLVLLLDRS
>NC_016111.1|WP_014142364.1|1734034_1734628_+|TetR/AcrR-family-transcriptional-regulator
MPRDGRPARLRLQKAAAELFGEHGFDRVTTAEIAARAGVTERTFYRHYADKREVFFASEADLRDALVAGVADAPEELEPLPALLWAFRTVVPVMEENRPLVEPMRRVIADTPALRERHQAKTAALTDALATALHGRGVAGPTASLAARVAMAAMSHAAAVWFVNPGHDLDRLLRDTFADVHALTAALAASDAEAARR
>NC_016111.1|WP_014142365.1|1734662_1735652_-|DNA-polymerase-III-subunit-delta
MAKKSSTDDVLAPVTLAVGQEDLLLDRAVAEVVAAARAADPDTDVRDLTPDALQPGTLAELVSPSLFAERKVVVVRNAHDLSADTVKDVKGYLDAPAEEITLVLLHAGGAKGKGLLDAARKARAREVACAKLTKPADRLAFVRAEFRTAGRSATPEACQALVDAIGSDLRELASACAQLGADVEGTVDAAVVARYYTGRAEATGFEVADLAVTGRTAEALERLRWALAVGQPLPGITFALASGVRAIGKLATAPRGARPGDLARELGMPPWKIDRVRQQMRGWSGDGVAMALRAVAEADAAVKGAGADPAYALEKAVVTISRAARSRRG
>NC_016111.1|WP_041825034.1|1735726_1735972_+|hypothetical-protein
MSNVRHVLVLPDRDAAHEAAEEAVSRFGLDDDPDIVREALAGEDDAEDAQWLVVIEDEPGELDPAELESLAEEYDGWREEE
>NC_016111.1|WP_014142367.1|1736589_1737048_+|pyridoxamine-5'-phosphate-oxidase
MTHPESPRSLALRKRQALHRLDHDQDVWVATADGDGVPCLVPLYFWWDGHAVWIATRGTNPTGVNLSRSGLARLSFGHTRDVVLMAGTATDFARDGLPAGVGDAFAAKFGWDPREDHPSYRYFRIVPELIQAWGTVAEMADRTLMRDGRWLL
>NC_016111.1|WP_014142368.1|1737095_1739600_-|ComEC/Rec2-family-competence-protein
MTTGTSPEETTGPADLRLVPPACAAWGAAAVTLGVPGRWTAAVAAGALAVALAVWVRLRGRGGDGRSGVAGVAVATALCACAAACSAGLAATALHRGPIPRLAARGAEATVDVTLTGDPHRTSARPPDAMPAPPVVVARAEAVRVAADGVTTTVRTPVLLIAEPGGSGRSGGSGERSPPGGADAWLRLLPSTTLRLTARLDRSDRPGDDIAALAVVHGAPRVIAGPSRLHRVAGSLRAGLRAATAQLAPDVRALLPGLVVGDTSGVPPDLRAAFDATDLSHLLAVSGANLTLVLALFIGPPALATRAERRGLAARSGLSLRRTAVLGAVLTAGFVVLCRPEPSVLRAAVCGLITLAAIGTGRRRSLLPALAATVLVLVLADPWLARSFGFALSVLATGALLTLAPRWAEGLRRHGVPPRAAEALGAAAAAQACCAPVIAVLAAHVSLVAVPCNLLAEVAVAPATVAGFAALAVAPVSLPAAKALAWLAGWPVRWVAWVARTGADLPGARLGWPGGWRGGLLLAVVTVAAVGLVRRIRPRPWMYAALVVALLVAVVRPAPLTRFATGWPPPGWRMVVCDVGQGDALVLNSGSGTGVVVDAGPDPVLADRCLRALGITRIPLLILTHFHADHVAGLPGVLRGRAVGAIETTTLDSPAPEAASVVRAAAAAHVPLVRAAAGERRRLGALEWQVLWPPPAPAELPDEGPNDASVALLVTVAGLTLALLGDLEPAAQQEVLARNPGLPRADVLKVAHHGSAHQDPALLARLRPRLALISCGAHNRYGHPSPRTLDALHAQGATVLRTDTAGSIAVTGRDAPVPGAGPPALSASVVKGAS
>NC_016111.1|WP_014142369.1|1739596_1740229_-|ComEA-family-DNA-binding-protein
MEPRTVVALAGVLVVVVAFAVHHFWAGRPRTVQVPAVVRGGAPVVARAAGASEGTAARATATVVVDVAGRVRRPGVARLPAGSRVVDALKAAGGAVPGTDTGALNLARLLVDGEQIRVGGPAPPDAPPDPAVGPAGPSAATGSVPGAGPVSLSTATLEQLDALPGVGPVLARHILDYRTQHGPFTSVTQLRRIPGVGDRRYKTLEPLVRP

Crispr_ID: NC_016111_4

• CRISPR_ID: NC_016111_4
• CRISPR_location: 1805689-1805948
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 4 spacers

Consensus repeat of NC_016111_4

Consensus_repeat	Method
CATCCCCGCCGAAGCGGGGCCAA	CRISPRCasFinder

spacers of NC_016111_4

>4.1|1805712|20|NC_016111|CRISPRCasFinder
CGAAAAGCGTGCAGCGGGAC
>4.2|1805755|48|NC_016111|CRISPRCasFinder
CATCCCTGTCACTTGAACATCAGGGATGCATGTTCACTTGTGAAGGAA
>4.3|1805826|38|NC_016111|CRISPRCasFinder
ACTTGCGCCCGACAACCCCTGCAAGGCGACTCTCGGGC
>4.4|1805887|39|NC_016111|CRISPRCasFinder
CGTTGTGCCCTGTTGAGCCATGCAAAGCGACTCTAGGGC

CRISPR arrays and Neighbor proteins around NC_016111_4

CRISPR arrays

The CRISPR arrays of NC_016111_4

>merge|NC_016111|4|1805689-1805948|CRISPRCasFinder
CCACCCCCGCGCAGCGGGGACAACGAAAAGCGTGCAGCGGGACCACCCCCGCTAACGCGGGGACAACATCCCTGTCACTTGAACATCAGGGATGCATGTTCACTTGTGAAGGAACATCCCCGCCGAAGCGGGGCCAAACTTGCGCCCGACAACCCCTGCAAGGCGACTCTCGGGCCATCCCCGCCGAAGCGGGTCCAACGTTGTGCCCTGTTGAGCCATGCAAAGCGACTCTAGGGCGACCCCCGCAGAGGCGGGGTCAA

>NC_016111|4|4|1805689-1805948|CRISPRCasFinder
CCACCCCCGCGCAGCGGGGACAA	CGAAAAGCGTGCAGCGGGAC
CACCCCCGCTAACGCGGGGACAA	CATCCCTGTCACTTGAACATCAGGGATGCATGTTCACTTGTGAAGGAA
CATCCCCGCCGAAGCGGGGCCAA	ACTTGCGCCCGACAACCCCTGCAAGGCGACTCTCGGGC
CATCCCCGCCGAAGCGGGTCCAA	CGTTGTGCCCTGTTGAGCCATGCAAAGCGACTCTAGGGC
GACCCCCGCAGAGGCGGGGTCAA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016111.1|WP_014142444.1|1801018_1802248_+|siphovirus-ReqiPepy6-Gp37-like-family-protein	unknown	unknown	gnl|CDD|379657
NC_016111.1|WP_014142443.1|1800022_1801006_+|phage-tail-family-protein	unknown	unknown	gnl|CDD|368574
NC_016111.1|WP_014142442.1|1798588_1800004_+|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_014142450.1|1805991_1806264_-|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_157894817.1|1804917_1805274_-|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_014142448.1|1804211_1804934_+|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl|CDD|119373
NC_016111.1|WP_014142452.1|1808515_1810039_-|DUF3987-domain-containing-protein	unknown	unknown	gnl|CDD|379041
NC_016111.1|WP_014142455.1|1810989_1811403_-|Lsr2-family-protein	unknown	unknown	gnl|CDD|378714
NC_016111.1|WP_014142449.1|1805322_1805553_+|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_078590659.1|1798378_1798576_+|transglycosylase-SLT-domain-containing-protein	unknown	unknown	gnl|CDD|381605
NC_016111.1|WP_014142446.1|1803334_1803868_+|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_157894819.1|1811939_1812176_-|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_014142447.1|1803958_1804147_+|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_157894818.1|1810056_1810674_-|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_014142459.1|1812246_1812675_-|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_014142451.1|1806374_1808378_-|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_014142457.1|1811682_1811943_-|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_014142454.1|1810753_1810993_-|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_014142456.1|1811440_1811686_-|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_014142445.1|1802248_1803331_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016111.1|WP_078590659.1|1798378_1798576_+|transglycosylase-SLT-domain-containing-protein	gnl|CDD|381605	cd13402, LT_TF-like, lytic transglycosylase-like domain of tail fiber-like proteins and similar domains. These tail fiber-like proteins are multi-domain proteins that include a lytic transglycosylase (LT) domain. Members of the LT family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, and the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL). LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.	1.3172e-28
NC_016111.1|WP_014142444.1|1801018_1802248_+|siphovirus-ReqiPepy6-Gp37-like-family-protein	gnl|CDD|379657	pfam14594, Sipho_Gp37, Siphovirus ReqiPepy6 Gp37-like protein. This family includes numerous phage proteins from Siphoviruses. The function of this protein is uncertain, but it is related to pfam06605. In Rhodococcus phage ReqiPepy6 this protein is called Gp37.	4.95061e-79
NC_016111.1|WP_014142443.1|1800022_1801006_+|phage-tail-family-protein	gnl|CDD|368574	pfam05709, Sipho_tail, Phage tail protein. This family consists of several Siphovirus and other phage tail component proteins as well as some bacterial proteins of unknown function.	2.56707e-19
NC_016111.1|WP_014142448.1|1804211_1804934_+|LysM-peptidoglycan-binding-domain-containing-protein	gnl|CDD|119373	cd00599, GH25_muramidase, Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family of muramidases contains a glycosyl hydrolase family 25 (GH25) catalytic domain and is found in bacteria, fungi, slime molds, round worms, protozoans and bacteriophages. The bacteriophage members are referred to as endolysins which are involved in lysing the host cell at the end of the replication cycle to allow release of mature phage particles. Endolysins are typically modular enzymes consisting of a catalytically active domain that hydrolyzes the peptidoglycan cell wall and a cell wall-binding domain that anchors the protein to the cell wall. Endolysins generally have narrow substrate specificities with either intra-species or intra-genus bacteriolytic activity.	3.65892e-39
NC_016111.1|WP_014142452.1|1808515_1810039_-|DUF3987-domain-containing-protein	gnl|CDD|379041	pfam13148, DUF3987, Protein of unknown function (DUF3987). A family of uncharacterized proteins found by clustering human gut metagenomic sequences.	3.25852e-09
NC_016111.1|WP_014142455.1|1810989_1811403_-|Lsr2-family-protein	gnl|CDD|378714	pfam11774, Lsr2, Lsr2. Lsr2 is a small, basic DNA-bridging protein present in Mycobacterium and related actinomycetes. It is a functional homolog of the H-NS-like proteins. H-NS proteins play a role in nucleoid organisation and also function as a pleiotropic regulator of gene expression.	3.82925e-06

Protein sequences

>NC_016111.1|WP_014142449.1|1805322_1805553_+|hypothetical-protein
MNEFIKKHAVRAFAVLAALVPVLVDQWPGIPWEALAAVVAAILGVGEVTQRHWDARLNAPVEPAAEVPAEPAGPAV
>NC_016111.1|WP_157894817.1|1804917_1805274_-|hypothetical-protein
MDSMQMQGPDGDVEVEEEDSGACDVADQEGTRILSEQCGTCILRAGTPVPPQAVRRVIRSALEADGHVVCHETAVRGVPAAVCRGFVDRYGDQALSIRLAHVIGIREIPPPSSLTSRF
>NC_016111.1|WP_014142448.1|1804211_1804934_+|LysM-peptidoglycan-binding-domain-containing-protein
MIKGIDVSSYQSTDFDTDGLDFVFIKATEGTSYVNPRMAGQAATARAAGLVVGFYHYISPGDMSAQAAFFVDRCDSVPGDVLFADWEEPGVSCAQKDQFIREVKRLRGSNHKVGLYCNQDYWLNRDSSSYAGDALWIADYVTPGRPRIQANWLFHQYTDRPLDTNVASFANRAALRSWAGGSSAPAPKPTPGPVTYTVRSGDTLSGIAQKYGTTVAKLSAANGIKDPDMIFAGQVLKIVK
>NC_016111.1|WP_014142447.1|1803958_1804147_+|hypothetical-protein
MKYHTGRVWQAEAEAQKARADRLQDDLAEIKERLARIEAENSRLLEILSVIDPERIAALRHP
>NC_016111.1|WP_014142446.1|1803334_1803868_+|hypothetical-protein
MRQLFGGTASDFAEDAAGTRVPGAIGTVWDGPSTGAQQYTDLTTADGAPMYQLTADSRGFVPAFFGPDGVERLWVDFGAGRVALTSVTVGERLDAHTSALDPHGDRAYADGAFLKNSGNGLEVTPDGKAIVSHVPHQFTGPLRLCSASGDLLGELYAEGGALKWRSSAGTVTTIAPA
>NC_016111.1|WP_014142445.1|1802248_1803331_+|hypothetical-protein
MGNEISYPFSSDSAGGGQQMVSQAQWQMMSRMFGPDRIDTQLVSSSYDGSALPFAASVVNGTSVSVSPGRALVGGFYYQLTAAQSVAIAANTGTNPRVDLIVLRADLAAGSVNLAVVQGQAAASPVVPQPTRTLGGRWELPLHQVTVPGNNGTLSVLSVGPFDMPSPVAVPWNASQLAQVTPVGTYIYDLDSNTNDTQSEYFVGRDGVAVTRHLGKARPYTPSLVNATDPLPTSYRTGRWRIIAPGMVWFAVTINNQNDGGAMLSGKNWIMGITLPPVPAATATRQVLHGHITNARGGGNLPNYMSVTALIEQGGTGQTTAYLYYPSPTTPAQGLDALPGIPAGAILTLSGVYQTNVYGD
>NC_016111.1|WP_014142444.1|1801018_1802248_+|siphovirus-ReqiPepy6-Gp37-like-family-protein
MGYRVEVRDAALNRIGVIDTWIKLDLVVRYCQTGSWQVLVEAGTPQADLLQKGGGVAIYQDGVKDPVLTGQIEAFQHYWTNDQHTSLGSLYFGGKCDNKLAYNRLAFPDPAKDATQQWQADDTRKVKGPAGQLIWSELNQALGPGALPSRQIPGVVIGSNVPSGPTLSDNLRWDVIGTKLESWIDTKTTGYRFLYDPNAKAINFHPFTPRDLSQDIRFSTELGNLREFTWALTAPTVTRVIVACQGAGKSRYLYQQTDTASEAEWGLQIEQFLDRRDLPIKADPTTGQPIKADLSVSDTDFQTALQAVKDAANEALTNGAKNGNFQIYPIDTDHVKFGRDYFVGDIVTVAVDGTEYVDIVREVSITVEQGGQTETVAPSIGEQGSGNPLNLYKTVFEMREKLRRLEARM
>NC_016111.1|WP_014142443.1|1800022_1801006_+|phage-tail-family-protein
MPIPAAVTSPNDAWSGDLTVPVPVEWQSTYVSIRGNNGQGEEIPLTGFLSAAWPAIMLQPGATGLDMPPFEIHADDSPNLDGSMYRGARAAARDILLPLYVYGIDRLTLRQFKRDLANALNPKSGYCVLTFIESDGIPRRLRCYYKGGMEGSEAADSAGFRWVSYGIQLTAMDPWFYGDTQVVASWSFGKPQPFLGKFLPLRLGKGTLATNTLQVSNPGDIEAWPVWRISGPVKSLILTGPDGSSWGIPAQASGADVIPIGRTLTVDCRPGYKTVTDDQGKNYFPLLAANPSLWPVPPGTSTVATNLVAGSGTAAVTMTLDPRYASY
>NC_016111.1|WP_014142442.1|1798588_1800004_+|hypothetical-protein
MQALAGTAGYASGTSGARPGWAWVGEEGPELVRFGGGETVLNHRDSMRAATRGLPGYASGTKSGVAVDAEKGASSLSAAVKRLYEIITKAFTSGRIGQGTENSLNRWLDGENKALSNLVKQRTDLAGKLKAAQAALKKVKDDEAKMASGISDKASSLRDLSSVFNSDGVSVTAGLSGLHERLAAIKKFQANLNTLVKRGFSSAIIENIAEAGPEQGGAMAQELLNATGAQIKDYNKTYAAIGTASDSLGNSVAKSYYATGEKAAQRLVDGLMSKDKVLVKKIESLADSIVRTLKRTLNFGSTTPVTSGLGALLTWLTGESQSVGRKPKPKPKPKPKPTPQVKRTVTTTTGYDSKGRSVTTVTTTITDPWAGTTTTITERTVDGRTTTTRSVRRTTKGYATGTLSASPGMALVGERGPELVDFRGGERVYTARQTADLMGPRYEIHIHEAKAENTTQAVLRALKYAEVMSGM
>NC_016111.1|WP_078590659.1|1798378_1798576_+|transglycosylase-SLT-domain-containing-protein
MQVESGGNPNAINLWDSNALAGMPSQGLMQTIPPTFDAYAGPYRSLGITNPLASIYAGLNYAIHR
>NC_016111.1|WP_014142450.1|1805991_1806264_-|hypothetical-protein
MRGVDPNGDTGDGGVILSEGEYMTLALLEVTGPARPTATHKRSYPVLGELIDAGYVEVFGSIYESTRVITEVGREALRKHREAGPGGQNE
>NC_016111.1|WP_014142451.1|1806374_1808378_-|hypothetical-protein
MREHVVHPLYYHRGDGHGPERLCDELTCRLCQHDCDCAACRELVDAPGLRVLVDSHDELPEGSIMTEVRESAATRAVMAELAREVGMWSSAGESFDMSDLPTYRDQAMRWLKQHSELSTRVIEGADYAVALTHYRMWTGWSPAADLEKREKKEMISVDMPAQLRKHAARLNGATKGERELTEACSRAVEAMREAGRSPNEGGTVQLTNAALGAALTVARGWLNSKNGNEMRAAKSLLSRHEMDYVPDDPREIRHEVKLPKSLSELMRRSFSHGQLRGRDDLLAELTAMSWTEAGAKGRVTVDGLRWLLDRARHFEGHDHPAVKRAATTFVQRYTPDHERTSKLVDAYLAAGDEHQDQEQQSPTEPERVVLVACGGAKAALDRAAAGDMYVGSYHRACRRAAEALTKDGGTVLILSARYGLLPLDQEIETYDVRAGEPGAMQPDALRDQAASMGLTDARVTVLGGSAYVELARSVWPQAEAPLNGGIGDQLQQLASIYGGDPEPLDETPETMPTAAPMKWYTGPLREVGGLPTRYQPRLHRMWFGGKAGRKGKAPGPWRRVEVTYTGDSVYELADLETGEVLLNAKLSTRIHWAALPGNWEVAQEVEAELVADEDQDDEPELPTKAGKSSRPLRQVPENFLYIAEEADTEAARAWWRRRCEQYARGEV
>NC_016111.1|WP_014142452.1|1808515_1810039_-|DUF3987-domain-containing-protein
MSTDATSPFAAMKYGPMGEAVERAMPTSEADPIGVWAAALSLYSSAISRTVRLENGRPVVVWTVLAGRSAIGRKGYALGTAKSMLRPVIGGYLDVRLEDGIASGASLVQMLYRLELETSGSRGGPDGRACIVEEEWASVLRMQKRDTKFSTLFRSAWDGKTISNRTKKELQIVPRPLLGFHAHITPGEWAAYVSKSDALGGSYNRLLPVLVERSKMLPHNNRWKFGDAKPLANAFQWATATERVMVFDTPAGKRYDVIRAEIEDRMVELPELLASYMERAAEQVHRIAAVLAATEKRTKIPRKAVDAAWAFVQYSMASVEKLVKEAAESGSRPLKTIEDLIRDALARYGGEATSTLLLRALGTRANAAAVKEAVEGMEDVEVYKAQTVGRGAKPIMYRLVEPAAGDQTEESPTEPETVVPSAAEKPERKATRPTLRVVRPARTLDPVHQDEPQQPVKAKPVKPLPKKTKKKAKPTGPKKAVTKKAVAKPKPAPAPAPADVNPIAALL
>NC_016111.1|WP_157894818.1|1810056_1810674_-|hypothetical-protein
MPADYRETQVSVYGRAVIVRTEKDGTIRTDKQLEAAHFNRVKAKLEELHAVGKRKKAAQLRLLGTKARGLRSHPRTGNLEEASKVYEAEALMVEKRKFSKPTCDFRDARRPFPKVTFTYPVIPEHLLEMHEEIAPRDIVMVTRGDDMASRVISSVVCDACATKQIEREGSVKLTIGDDEYDLCGEHGERFRAWFADALKPAQAAA
>NC_016111.1|WP_014142454.1|1810753_1810993_-|hypothetical-protein
MSYTKRWADDVKDVQEQAVRGRELPTARERLVALRELFEECGYLARVYPCPCRAAAELVSVAAAAWQESAPDEPAVTAA
>NC_016111.1|WP_014142455.1|1810989_1811403_-|Lsr2-family-protein
MSGVDEPARTPGEVPEDYDPEDVAAWCLRQRWFTTGPWDTEFQKREIHPKVLALYRKDRARELEREKRGAAERTRLAQMWAEAAAARERAAEQARRMRDMRRWGPENGYFVGTRGCIPRRVVEAYNQAHGIEEGDSS
>NC_016111.1|WP_014142456.1|1811440_1811686_-|hypothetical-protein
MSGMKRYVEERWKAEGRIGEYRRIAELHAADTVDGLLVDAWTAAACVTLHDALSERNRARWLAMSTAQQCEVAVRLTMGGR
>NC_016111.1|WP_014142457.1|1811682_1811943_-|hypothetical-protein
MTTSTRWIATFDEEAGQLDIYSSNGPGPMYTWRRRHDLTHAIQTLILWSWEHPTNGWRTAPQWERLGESSVMVADAWPVRISVEDR
>NC_016111.1|WP_157894819.1|1811939_1812176_-|hypothetical-protein
MGKGSTKSEVQHFQRLDDGRTGCWTWNCGKAATRWIDMERYGIRRWLSKAYCDGHGNDEFKDSHHTYRVRQIKEGNNK
>NC_016111.1|WP_014142459.1|1812246_1812675_-|hypothetical-protein
MSWGYEVWVCDCGYTKPAEHDGSCGIWKRTAIHWNDRWFGAFEEAAQHGHAYVMAVPVGATLERGWKAHITFEHIRGGGLCKECRKRRGPLTTTPFGKKFMCEDCRSAFRRDHERNAYVTGRDPDSRLYRPVLDVAQEDAKH

Crispr_ID: NC_016111_5

• CRISPR_ID: NC_016111_5
• CRISPR_location: 2666654-2666737
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_016111_5

Consensus_repeat	Method
ACCTCGACGCAGTTGCCGCCCTGG	CRISPRCasFinder

spacers of NC_016111_5

>5.1|2666678|36|NC_016111|CRISPRCasFinder
TCACCGCTGTAGCTCGACTTGCGCCAGGCAAGGGCT

CRISPR arrays and Neighbor proteins around NC_016111_5

CRISPR arrays

The CRISPR arrays of NC_016111_5

>merge|NC_016111|5|2666654-2666737|CRISPRCasFinder
ACCTCGACGCAGTTGCCGCCCTGGTCACCGCTGTAGCTCGACTTGCGCCAGGCAAGGGCTACTTCGACGCAGTTGCCGCCCTGG

>NC_016111|5|5|2666654-2666737|CRISPRCasFinder
ACCTCGACGCAGTTGCCGCCCTGG	TCACCGCTGTAGCTCGACTTGCGCCAGGCAAGGGCT
ACTTCGACGCAGTTGCCGCCCTGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016111.1|WP_014143268.1|2658728_2659271_-|DUF3291-domain-containing-protein	unknown	unknown	gnl|CDD|378694
NC_016111.1|WP_106433172.1|2661023_2661413_-|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_014143282.1|2670495_2671128_-|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_014143280.1|2668556_2669225_-|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_014143288.1|2674010_2674373_+|DsrE-family-protein	unknown	unknown	gnl|CDD|224955
NC_016111.1|WP_014143285.1|2672716_2673148_-|transcriptional-repressor	unknown	unknown	gnl|CDD|223806
NC_016111.1|WP_014143263.1|2655540_2655987_+|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|182137
NC_016111.1|WP_014627918.1|2665241_2665619_-|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_014143284.1|2671695_2672664_-|folate-binding-protein-YgfZ	unknown	unknown	gnl|CDD|223431
NC_016111.1|WP_041824660.1|2659542_2660076_-|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_014143267.1|2658254_2658536_+|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_014143281.1|2669448_2670417_-|asparaginase	unknown	unknown	gnl|CDD|377601
NC_016111.1|WP_014143279.1|2666777_2667587_-|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|238045
NC_016111.1|WP_014143283.1|2671254_2671680_+|D-tyrosyl-tRNA(Tyr)-deacylase	unknown	unknown	gnl|CDD|235383
NC_016111.1|WP_014626964.1|2667669_2668440_+|IS5/IS1182-family-transposase	unknown	unknown	gnl|CDD|372577
NC_016111.1|WP_014143264.1|2656020_2656446_+|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|176106
NC_016111.1|WP_014143286.1|2673204_2673768_-|FABP-family-protein	unknown	unknown	gnl|CDD|378046
NC_016111.1|WP_014143265.1|2656464_2657190_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|187585
NC_016111.1|WP_014143266.1|2657288_2658194_+|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|182137
NC_016111.1|WP_014143274.1|2661553_2663056_-|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl|CDD|377587

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016111.1|WP_014143268.1|2658728_2659271_-|DUF3291-domain-containing-protein	gnl|CDD|378694	pfam11695, DUF3291, Domain of unknown function (DUF3291). This bacterial family of proteins has no known function.	1.48753e-31
NC_016111.1|WP_014143288.1|2674010_2674373_+|DsrE-family-protein	gnl|CDD|224955	COG2044, COG2044, Predicted peroxiredoxins [General function prediction only].	7.60878e-17
NC_016111.1|WP_014143285.1|2672716_2673148_-|transcriptional-repressor	gnl|CDD|223806	COG0735, Fur, Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism].	1.7125e-34
NC_016111.1|WP_014143274.1|2661553_2663056_-|WXG100-family-type-VII-secretion-target	gnl|CDD|377587	pfam06013, WXG100, Proteins of 100 residues with WXG. ESAT-6 is a small protein appears to be of fundamental importance in virulence and protective immunity in Mycobacterium tuberculosis. homologs have been detected in other Gram-positive bacterial species. It may represent a novel secretion system potentially driven by the pfam01580 domains in the YukA-like proteins.	0.0036914
NC_016111.1|WP_014143263.1|2655540_2655987_+|LysR-family-transcriptional-regulator	gnl|CDD|182137	PRK09906, PRK09906, DNA-binding transcriptional regulator HcaR; Provisional.	1.18222e-24
NC_016111.1|WP_014143281.1|2669448_2670417_-|asparaginase	gnl|CDD|377601	pfam06089, Asparaginase_II, L-asparaginase II. This family consists of several bacterial L-asparaginase II proteins. L-asparaginase (EC:3.5.1.1) catalyzes the hydrolysis of L-asparagine to L-aspartate and ammonium. Rhizobium etli possesses two asparaginases: asparaginase I, which is thermostable and constitutive, and asparaginase II, which is thermolabile, induced by asparagine and repressed by the carbon source.	5.84601e-144
NC_016111.1|WP_014143279.1|2666777_2667587_-|helix-turn-helix-transcriptional-regulator	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	9.19046e-08
NC_016111.1|WP_014143264.1|2656020_2656446_+|LysR-family-transcriptional-regulator	gnl|CDD|176106	cd08414, PBP2_LTTR_aromatics_like, The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold. This CD includes the C-terminal substrate binding domain of LTTRs involved in degradation of aromatic compounds, such as CbnR, BenM, CatM, ClcR and TfdR, as well as that of other transcriptional regulators clustered together in phylogenetic trees, including XapR, HcaR, MprR, IlvR, BudR, AlsR, LysR, and OccR. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the substrate-binding domains from ionotropic glutamate receptors, LysR-like transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	9.84688e-21
NC_016111.1|WP_014626964.1|2667669_2668440_+|IS5/IS1182-family-transposase	gnl|CDD|372577	pfam13359, DDE_Tnp_4, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	3.93626e-15
NC_016111.1|WP_014143283.1|2671254_2671680_+|D-tyrosyl-tRNA(Tyr)-deacylase	gnl|CDD|235383	PRK05273, PRK05273, D-tyrosyl-tRNA(Tyr) deacylase; Provisional.	1.74302e-85
NC_016111.1|WP_014143286.1|2673204_2673768_-|FABP-family-protein	gnl|CDD|378046	pfam08768, DUF1794, Domain of unknown function (DUF1794). This domain forms a beta barrel structure but the function is unknown. The GO annotation for this protein indicates that the protein has a function in nematode larval development and has a positive regulation on growth rate.	1.0185e-62
NC_016111.1|WP_014143265.1|2656464_2657190_-|SDR-family-oxidoreductase	gnl|CDD|187585	cd05324, carb_red_PTCR-like_SDR_c, Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs. PTCR is a classical SDR which catalyzes the NADPH-dependent reduction of ketones on steroids and prostaglandins. Unlike most SDRs, PTCR functions as a monomer. This subgroup also includes human carbonyl reductase 1 (CBR1) and CBR3. CBR1 is an NADPH-dependent SDR with broad substrate specificity and may be responsible for the in vivo reduction of quinones, prostaglandins, and other carbonyl-containing compounds. In addition it includes poppy NADPH-dependent salutaridine reductase which catalyzes the stereospecific reduction of salutaridine to 7(S)-salutaridinol in the biosynthesis of morphine, and Arabidopsis SDR1,a menthone reductase, which catalyzes the reduction of menthone to neomenthol, a compound with antimicrobial activity; SDR1 can also carry out neomenthol oxidation. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	6.19344e-87
NC_016111.1|WP_014143266.1|2657288_2658194_+|LysR-family-transcriptional-regulator	gnl|CDD|182137	PRK09906, PRK09906, DNA-binding transcriptional regulator HcaR; Provisional.	1.65441e-36
NC_016111.1|WP_014143284.1|2671695_2672664_-|folate-binding-protein-YgfZ	gnl|CDD|223431	COG0354, COG0354, Predicted aminomethyltransferase related to GcvT [General function prediction only].	1.78724e-52

Protein sequences

>NC_016111.1|WP_014627918.1|2665241_2665619_-|hypothetical-protein
MTMPPERVRAAALLTDLGSHDPRLSLSVLDVARLTPLAARWLASGLPDTALHTALTASLPPLIHSPAALLTHRLRTEPPLPPQPPRPHHPSGPLPECTSCRDPLPRNSSAHHCHRCASVPVPLAT
>NC_016111.1|WP_014143274.1|2661553_2663056_-|WXG100-family-type-VII-secretion-target
MVDLNPLHWINKINESIGHSMADVLEFIGITNPAVDPDGIREVARHWKALGDALDDAHWHVGQALGDLRWEGRAADAFHARAVEVRDQCEKTAKACHDGHDQLNRFADQAHELISEIGKLCAEILEFELAALPLSLLTGPLAEVASNLAAGERAVKITALIARIAEAARTVDRAAEAVLESLGTLGRALKALTPIAKMAAGGAATTLGYDAIVNPDRLRHADTLEQDVEIGALLGIIGGGFGKGIQGMLKGLGPRMVPALSDAGLLGELGGEDVAISRLGALMREENLPPEPGSEPPLTPEPVPPENPPDLLAEYESRSDPDALEKYDRIRAMTDDVERIAENCGIAPEIVTRAKENLFLKKHDVQFGPGKTVRNVYFNAYDELASVWLKARNWNVRPNTIGMVRGLIAHEYVEGRLMEAGVPYSSDDPSRWVAQPVNSRGNVGAHELSPLSLNGWPVTLEGTLKHWKLLGIEPPSAPVTDDLSNLDVVVDSILKWWKSA
>NC_016111.1|WP_106433172.1|2661023_2661413_-|hypothetical-protein
MGGADRWPFFDIAGRVAPAVRADPDQADRLERYLEENVGGFSTENACRWALRWATLRDVQGDHLPRLADPFEPLILMYERGGEIVPDETRSFNFGTRVVRALTWQEHLSPDPIVSLDPATLDALDAEES
>NC_016111.1|WP_041824660.1|2659542_2660076_-|hypothetical-protein
MGGKLAEAMLERLFVIDWRDSKNSIQHNVSRAKLMREYLRRAALWVNELGGTDRWPFFDIAGRIAPSVRTNPDLAARLERYIEENVGGISTEDALRAILRWATLRDVHKGQLPYPNDPFEPLLVMYERGGEVVADEARFFNFGHRSVRLKPWPQHLSPDPVVSLDPATLDALDREES
>NC_016111.1|WP_014143268.1|2658728_2659271_-|DUF3291-domain-containing-protein
MPHLALYTFSVLKSPLADPAPLTDEFYDIGEAVYREIGQRSGYLAHAEAADAERGVLFGADWGAWGEFTVPTWYGKGRTRETTALAATLSLWTGLRPAFDAIYTGLHRAALNRRYDWFERTGHPNYVAWWVSDDAIPTWRDGVSRLQHLHDHDPAPHAFTFHHAFAPDATPARLKGNGYA
>NC_016111.1|WP_014143267.1|2658254_2658536_+|hypothetical-protein
MNAALPDGWTIERVRSVSGDREAAVLSLDRLVVVEDYVRADRTPLQPDVILSFHNLCLVRDEGDWFIGHLGDDGSVICWASYGSGLEEAIRGL
>NC_016111.1|WP_014143266.1|2657288_2658194_+|LysR-family-transcriptional-regulator
METRELRYFVAVAEELHFGRAALRLGIAQPPLSRAISRLERRLGVTLLERTSRAVALTEAGAVLLAEARAALDAVEAAERRTRRAAHPTNGVVLATKAGASGDLLAELLDVYAAEPDAVTVDLLLCGIGEQERMLRDGRADVALLHLPYDGTAGFDTEELRVERQVVVLPAGHPLTGRDHVRMAEVTDLPGLPVPRWPGRDGTYPDGPGPKARDHTQLFQLIALGRACWIAPESCRTQLREGLAALPVVDAPPVTTVLAWPPQSRSRGVAGLVRVGVREFRAGRGEFSQARGTTTARSGAR
>NC_016111.1|WP_014143265.1|2656464_2657190_-|SDR-family-oxidoreductase
MSEQTIALVTGANKGIGYEIAAGLGALGWRVGVGARDEERRGTAVAKLRAAGADAFGVPLDVTDDASVADAAALIEERAGHLDVLVNNAAITGGSAQMPTTAGPAVVRAAVETNVIGVIRVTNAMLPLLRRSPSPRIVNMSSGVGSLTRQSTPGAETGPIAVAYAPSKTFLNAVTVQYAKELRGTGILINAACPGYCATDLNGFRGVRTPEQGAAIGIRLATLPDDGPTGGFFDDEGEVPW
>NC_016111.1|WP_014143264.1|2656020_2656446_+|LysR-family-transcriptional-regulator
MLSAERFMALVPAAHPLAGRAELSASELSATGLLTWPHQINSGLCDRLLAAFHIGGADLRIIRTADSVHAIAAHVAAGTGVGITVGSALDQQPPGLRVIPITGPSTTVDQVVLTPAEPSRTAVALRDLLLEASAEASSTGR
>NC_016111.1|WP_014143263.1|2655540_2655987_+|LysR-family-transcriptional-regulator
MERIELEAFVAVAEELHFGRAAARLHRGQPTVSDAVRRLESSLGGRLFHRTSRRVSLTDLGEALLPDAHAALAQLRRFQQRGRSLAAGDRARTTLVVAHAEYTGHQLLLRCLPQLRERFPDVTIVPEAMPTTAQLPALRAETIGLGIG
>NC_016111.1|WP_014143279.1|2666777_2667587_-|helix-turn-helix-transcriptional-regulator
MINNQGSSNLRMFGSCVRYLRLRAGLSLEQLGALTNYSKSLVAAIETGDRMPSEAFILKAGKVFGAEDLLMEMAQHLSRETYPKWFLEFLELEKKARALHTYENHVIPGLLQTEEYMRAVFSAHCPALDDKQIEERVAGRLARHVIFDRRPAPVLSFVLEMATILRPIGGLAVQRAQLKRLLEVSEQRNVEIQLMRLERDTHAGLNGPFVLLETDDRRNLAYVEGQHGSRVFEDPEIVSDLTARYGIIRAQASSPEESRRLIEQVAKEL
>NC_016111.1|WP_014626964.1|2667669_2668440_+|IS5/IS1182-family-transposase
MSGVITASEPSWIAPFTGLSPRQFGKLITALRREGVDPVRKGRPWSLPLEDRVLLIAAYWRTNLTLRQLAPLFGVSKSAADRIIDHLGPALALQQRKRFRKDTVLIVDGTLVPTRDHTIAEQSKNYRYSTNHQVVIDADTRLVVAVGRPVAGNRNDCKAWELSGAKDAVGKTTVIADGGYRGTGLVIPHRREKGQTELPEWKEEHNASHRKVRARVEHVFARMKGWKILRDCRLKGDGVQHAMLGIARLHNLVLAG
>NC_016111.1|WP_014143280.1|2668556_2669225_-|hypothetical-protein
MTTRRARRTVRSAGLLAIAAAAAFSLTACGPNDPAGSSNAAGSGNASASTSTSGTGSTGSSAQGGTSGTHHSTTAGTASTNGGTTSPTRTQTLPDGSKAEIYRLGSQHYRAKIVNNGSVLATLETNQHDAGLDANDMFVVLTLDGQVHAWMGGGHQGPGTFDLAGGWKAKVTKVGELRYRAQIIGNDGSVDATLETDQHDVGLDANGAYVVLSNGGVISAHM
>NC_016111.1|WP_014143281.1|2669448_2670417_-|asparaginase
MTSVVPDQHAQLPVLAEVVRSGFTEGRHHGSLVVLDADGKVELALGDVTSPVFPRSSNKPMQAEAVLRAGVDLDGELLALAAASHSGETFHLDGVRRLLAAAGLPESALRTPADLPLDATESETWLAAGGVRKPILMNCSGKHAAMLWACVRNGWPTESYLDQDHPLQRLVLDVVRERSGESVDHVGVDGCGAPLMAISLTGLARVFRSYVTADPGTPARRVADAMRAHPEYVAGTRRPDTWLMRELPGTLSKMGAEAVQAVALPDGRALAFKIDDGASRALGPVLARTLRTMGVDAPVLDRIADAPLLGGGVRVGEIRAAF
>NC_016111.1|WP_014143282.1|2670495_2671128_-|hypothetical-protein
MTTPQDPVNGTPDPGATVIGTGTAHTTGSAPTNLTDLTALALPRLRTLRRDAQQEEADLSYLRRLLQGRVDILRAELARRTDPPAGRPAPPPRRPVVLPAALPLLDRLPEILTDDPSAVRQSARHVTLGTPRGAEYRRLADRILDDVGLSDLSARTDTELRAGLARMEALEQDISRRRRGLQETVDGCSAEITRRYREGEARIDDLLSGA
>NC_016111.1|WP_014143283.1|2671254_2671680_+|D-tyrosyl-tRNA(Tyr)-deacylase
MRAVAQRVTEAAVTVDGETVGKITGPGLCVLVGVTHDDTPEKAAQLARKLWSLRILPDERSCSDIDAPLLVVSQFTLYGDARKGRRPTWNAAAPGPVAEPLVDEVVARLRELGATVETGRFGASMKVSLVNDGPFTVVLEI
>NC_016111.1|WP_014143284.1|2671695_2672664_-|folate-binding-protein-YgfZ
MTSSPLLSLPGAVPAESPDEGVAGHYGDPFREQRALADGTAFVDLSHRGVVTVTGEDRLAWLHLLLTQHVSELPAHQATEALVLSAHGHVEHALYLVDDGTTTWAHVEPGTQGDLLAYLESMKFFYRVETADAGDAYAVVHLPAGNITEVPADWAVRETPWGRDVFVPRAELEAFAGRAGTPAGVLAHEALRIEAHRPRLGLETDHRTIPHEVGWLESAVHLNKGCYRGQETVARVHNLGRPPRRLVFLHLDGSEVKLPGHGAPVRLAEDGPDGRQIGFVTSSARHHELGPIALALVKRNVPADAVLLADTVPANQEVVVAP
>NC_016111.1|WP_014143285.1|2672716_2673148_-|transcriptional-repressor
MVTTDWKKDLRERGYRLTPQRQLVLEAVDTLEHATPDDILTEVRRTASGVNISTVYRTLELLEELGLVSHAHLGHGAPTYHLADRHHHMHLVCRDCGSVIEADVSVAQPLIDGLRQQFGFDTDMKHFAIFGRCADCAGSAAGG
>NC_016111.1|WP_014143286.1|2673204_2673768_-|FABP-family-protein
MIEIPSDLHPDIAPLVFLLGDWAGAGVFDFPGAEKCNFGQEVTFRHDGRPFLEYTSHTWVLDGDGNKVRPLESESGFWRVDGDRKVEVVMTRDSGVIEIWYGELAENKPQIDLATDAVARIASADEYSGGKRLFGYVKGDLMWVGEKATPSVPLRPYMSAHLKKVVSPAEWIKDIKDLPDDGIAFFK
>NC_016111.1|WP_014143288.1|2674010_2674373_+|DsrE-family-protein
MTKQLVIKVTAGADAPERCSQAFTVAAVAVASGVEVSLWLTGESSWFALPGRAAEFELPHAAPLPELIDAILTGGRVTLCTQCAARRDITEDDVVEGVRIAGAQVFVREIMGEGVQALVY

Crispr_ID: NC_016111_6

• CRISPR_ID: NC_016111_6
• CRISPR_location: 3300037-3300113
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_016111_6

Consensus_repeat	Method
GCGGGAGGTACTGGGTGGCCGCG	CRISPRCasFinder

spacers of NC_016111_6

>6.1|3300060|31|NC_016111|CRISPRCasFinder
GCGTCCTCGCCCTCGGGGGCCACGGAGGCGT

CRISPR arrays and Neighbor proteins around NC_016111_6

CRISPR arrays

The CRISPR arrays of NC_016111_6

>merge|NC_016111|6|3300037-3300113|CRISPRCasFinder
GCGGGAGGTACTGGGTGGCCGCGGCGTCCTCGCCCTCGGGGGCCACGGAGGCGTGCGGCAGGTACTGGGTGGCCGCG

>NC_016111|6|6|3300037-3300113|CRISPRCasFinder
GCGGGAGGTACTGGGTGGCCGCG	GCGTCCTCGCCCTCGGGGGCCACGGAGGCGT
GCGGCAGGTACTGGGTGGCCGCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016111.1|WP_014143863.1|3293048_3293384_-|thioredoxin	unknown	unknown	gnl|CDD|200072
NC_016111.1|WP_014143870.1|3303058_3304507_+|CCA-tRNA-nucleotidyltransferase	unknown	unknown	gnl|CDD|131739
NC_016111.1|WP_014143862.1|3292338_3292956_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
NC_016111.1|WP_014143874.1|3308309_3311177_+|penicillin-binding-protein	unknown	unknown	gnl|CDD|223815
NC_016111.1|WP_014143865.1|3294628_3295507_-|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_106433127.1|3311317_3312841_+|DUF2029-domain-containing-protein	unknown	unknown	gnl|CDD|227937
NC_016111.1|WP_014143872.1|3306140_3307223_-|inositol-3-phosphate-synthase	unknown	unknown	gnl|CDD|132491
NC_016111.1|WP_014143867.1|3296316_3298038_-|serine/threonine-protein-kinase	unknown	unknown	gnl|CDD|270875
NC_016111.1|WP_173405716.1|3295503_3296193_-|RNA-polymerase-sigma-factor-SigM	unknown	unknown	gnl|CDD|236604
NC_016111.1|WP_078590744.1|3288738_3289500_+|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG	unknown	unknown	gnl|CDD|234637
NC_016111.1|WP_014143877.1|3314100_3315219_-|peptidoglycan-bridge-formation-glycyltransferase-FemA/FemB-family-protein	unknown	unknown	gnl|CDD|225224
NC_016111.1|WP_014143878.1|3315338_3315656_-|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_014143864.1|3293433_3294414_-|thioredoxin-disulfide-reductase	unknown	unknown	gnl|CDD|273540
NC_016111.1|WP_078590746.1|3289782_3290874_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|224113
NC_016111.1|WP_014143873.1|3307276_3307906_-|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|224609
NC_016111.1|WP_014143869.1|3300404_3302825_-|membrane-protein	unknown	unknown	gnl|CDD|212096
NC_016111.1|WP_041824753.1|3290870_3292007_+|ParB/RepB/Spo0J-family-partition-protein	unknown	unknown	gnl|CDD|275105
NC_016111.1|WP_014143871.1|3304606_3305947_-|MFS-transporter	unknown	unknown	gnl|CDD|340863
NC_016111.1|WP_014143876.1|3313012_3314044_-|alanine-racemase	unknown	unknown	gnl|CDD|376473
NC_016111.1|WP_157894833.1|3292181_3292334_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016111.1|WP_014143863.1|3293048_3293384_-|thioredoxin	gnl|CDD|200072	TIGR01068, Thioredoxin-like_protein_slr0233, thioredoxin. Several proteins, such as protein disulfide isomerase, have two or more copies of a domain closely related to thioredoxin. This model is designed to recognize authentic thioredoxin, a small protein that should be hit exactly once by this model. Any protein that hits once with a score greater than the second (per domain) trusted cutoff may be taken as thioredoxin. [Energy metabolism, Electron transport].	6.61919e-42
NC_016111.1|WP_014143864.1|3293433_3294414_-|thioredoxin-disulfide-reductase	gnl|CDD|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	6.94133e-159
NC_016111.1|WP_014143862.1|3292338_3292956_+|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	3.38211e-05
NC_016111.1|WP_014143874.1|3308309_3311177_+|penicillin-binding-protein	gnl|CDD|223815	COG0744, MrcB, Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane].	1.4675e-139
NC_016111.1|WP_106433127.1|3311317_3312841_+|DUF2029-domain-containing-protein	gnl|CDD|227937	COG5650, COG5650, Predicted integral membrane protein [Function unknown].	1.33315e-30
NC_016111.1|WP_014143872.1|3306140_3307223_-|inositol-3-phosphate-synthase	gnl|CDD|132491	TIGR03450, mycothiol_INO1, inositol 1-phosphate synthase, Actinobacterial type. This enzyme, inositol 1-phosphate synthase as found in Actinobacteria, produces an essential precursor for several different products, including mycothiol, which is a glutathione analog, and phosphatidylinositol, which is a phospholipid.	0
NC_016111.1|WP_014143867.1|3296316_3298038_-|serine/threonine-protein-kinase	gnl|CDD|270875	cd13973, PK_MviN-like, Pseudokinase domain of the peptidoglycan biosynthetic protein MviN. The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. This family is composed of the mycobacterial protein MviN and similar proteins. MviN is an integral membrane protein that is essential for growth and is required for cell wall integrity and peptidogylcan (PG) biosynthesis. It comprises of 14 predicted transmembrane (TM) helices at the N-terminus, followed by an intracellular pseudokinase domain linked through a single TM helix to a carbohydrate binding extracellular domain. Phosphorylation of the MviN pseudokinase domain by the PG-sensitive serine/threonine protein kinase PknB recruits a forkhead associated (FHA) domain protein FhaA, which modulates local PG synthesis at cell poles and the septum. The MviN pseudokinase forms a canonical receptor kinase dimer.	1.39315e-57
NC_016111.1|WP_173405716.1|3295503_3296193_-|RNA-polymerase-sigma-factor-SigM	gnl|CDD|236604	PRK09643, PRK09643, RNA polymerase sigma factor SigM; Reviewed.	7.27706e-90
NC_016111.1|WP_078590744.1|3288738_3289500_+|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG	gnl|CDD|234637	PRK00107, gidB, 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG.	1.39309e-75
NC_016111.1|WP_014143877.1|3314100_3315219_-|peptidoglycan-bridge-formation-glycyltransferase-FemA/FemB-family-protein	gnl|CDD|225224	COG2348, COG2348, Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis].	1.06252e-38
NC_016111.1|WP_014143870.1|3303058_3304507_+|CCA-tRNA-nucleotidyltransferase	gnl|CDD|131739	TIGR02692, putative_tRNA_nucleotidyltransferase, tRNA adenylyltransferase. The enzyme tRNA adenylyltransferase, also called tRNA-nucleotidyltransferase and CCA-adding enzyme, can add or repair the required CCA triplet at the 3'-end of tRNA molecules. Genes encoding tRNA include the CCA tail in some but not all bacteria, and this enzyme may be required for viability. Members of this family represent a distinct clade within the larger family pfam01743 (tRNA nucleotidyltransferase/poly(A) polymerase family protein). The example from Streptomyces coelicolor was shown to act as a CCA-adding enzyme and not as a poly(A) polymerase. [Protein synthesis, tRNA and rRNA base modification].	0
NC_016111.1|WP_078590746.1|3289782_3290874_+|AAA-family-ATPase	gnl|CDD|224113	COG1192, Soj, ATPases involved in chromosome partitioning [Cell division and chromosome partitioning].	1.6652e-87
NC_016111.1|WP_014143873.1|3307276_3307906_-|helix-turn-helix-transcriptional-regulator	gnl|CDD|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	2.80079e-19
NC_016111.1|WP_014143869.1|3300404_3302825_-|membrane-protein	gnl|CDD|212096	cd01022, GH57N_like, N-terminal catalytic domain of heat stable retaining glycoside hydrolase family 57. Glycoside hydrolase family 57(GH57) is a chiefly prokaryotic family with the majority of thermostable enzymes coming from extremophiles (many of these are archaeal hyperthermophiles), which exhibit the enzyme specificities of alpha-amylase (EC 3.2.1.1), 4-alpha-glucanotransferase (EC 2.4.1.25), amylopullulanase (EC 3.2.1.1/41), and alpha-galactosidase (EC 3.2.1.22). This family also includes many hypothetical proteins with uncharacterized activity and specificity. GH57s cleave alpha-glycosidic bonds by employing a retaining mechanism, which involves a glycosyl-enzyme intermediate, allowing transglycosylation.	0.00887309
NC_016111.1|WP_041824753.1|3290870_3292007_+|ParB/RepB/Spo0J-family-partition-protein	gnl|CDD|275105	TIGR04285, parB-like_partition_protein, nucleoid occlusion protein. This model describes nucleoid occlusion protein, a close homolog to ParB chromosome partitioning proteins including Spo0J in Bacillus subtilis. Its gene often is located near the gene for the Spo0J ortholog. This protein bind a specific DNA sequence and blocks cytokinesis from happening until chromosome segregation is complete.	3.15541e-76
NC_016111.1|WP_014143871.1|3304606_3305947_-|MFS-transporter	gnl|CDD|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	5.45164e-40
NC_016111.1|WP_014143876.1|3313012_3314044_-|alanine-racemase	gnl|CDD|376473	pfam01168, Ala_racemase_N, Alanine racemase, N-terminal domain.	5.13002e-10

Protein sequences

>NC_016111.1|WP_014143867.1|3296316_3298038_-|serine/threonine-protein-kinase
MAERSTAAVDVANESGAPPLTAGAGGATVDGATAQSGAQDADRSDPEEGAEATPTTEPPELHSGHKLARRYRLEECLTQAAGFSSWRAVDEKLRRAVGVHVMPADSPRARNVLAAARSAALLGDPRFVQVLDAVEENDLVYVVHEWLPDATELTPLLAAGPMEPHEAYQLVSQLSQAMAVAHREGLAHLRLNPGAVLRTETGQYRIRGLAVAAALRGVESDRPKRTDTEAIGALLYAALTARWPYPDDAHGLTGLPKGLGLVAPDQVRAGVHRGLSDIAMRALVNDGATPSRQEKPVTTPEELAKAVAGLPKIRPPEPQAPPFPQVGYRQPPARPAQPQQARPVPAAPPPPALPGRTGTAVKWGVAALLIAALGLGSWQIADTLMNRDNGAPTTNSQNQKPTTHSGGGGTAAKRTGKPLPIVGALEYAPDGTFQDEGDARATYDGKPDTYWHSHSFDDGPELQPSVKKGVGLIYDLGSTQKVTGAEIGLKFGGDHTTVSLYASDEYSSAASMSSMRKLGTVQTSDNTAKFQLGQPAQARYLVIWLTAMPYFGQDNYSKPGYKQGITEVSFTGQ
>NC_016111.1|WP_173405716.1|3295503_3296193_-|RNA-polymerase-sigma-factor-SigM
MTRGNPTESADDAALLARHVAGEPDAFGELVRRHRDRLWAVALRTLGDPEEAADAVQDALVSAFRAAHTFRGQSAVTTWLHRITVNACLDRARKSAARRTAPVPDEERFDTLLEPHESAEAPAERDELHRELIRALGALPPDQRAALVLVDMQGYPVAEAAEVLGVPPGTVKSRCARGRARLLPLLTHLRSGRGDNGSPPGGRNRAEATSVPQTAAKDQDVVKGGGGQR
>NC_016111.1|WP_014143865.1|3294628_3295507_-|hypothetical-protein
MTSPPDTNGHPEVAEISALAEGILPPERSADLRGHLAVCVLCTEVRDSLDEIRGLLGTLPGPPRMPEEIAGRIDAALAAEALISATTPAPEAPATEPVSRETDGAAGAVSRETAATAGRRPEGHPTAATGPGRGRPRRRRARLALTGAAGAAVLAFGGLLTYSLTSGPAVTGTSRQAAAFSGTELPVRVHQLLAGTPGTGAGTAAPHTGVNTPFTAHVAPGVPGCVLKGTGRGEAPLASAGGSYQGHASYLVVFPHPGDGAKVDAYVVDASCVSSGSPGPGTVLTRQTYDRS
>NC_016111.1|WP_014143864.1|3293433_3294414_-|thioredoxin-disulfide-reductase
MSDVRNVIIIGSGPSGYTAALYTARASLKPLVFEGAVTAGGALMNTTEVENFPGFRDGIMGPDLMDNMRAQAERFGAELIPDDVVEVDLTGDIKLVTDSAGTVHRAKSVIVATGSGYRKLGLPNEDTFSGRGVSWCATCDGFFFKDQDIVVVGGGDTAMEEATFLSRFAKSVTIVHRRDTLRASKAMQERAFADPKISFIWDSEVSEIHGDGKLSGLTLRNVRTGATSKLPVTGLFIAIGHDPRTELFKGQLDLDEEGYLKVEAPSTRTNLAGVFAAGDVVDHTYRQAITAAGTGCSAALDAERYLAALSDRPEETAEPEKAAAAL
>NC_016111.1|WP_014143863.1|3293048_3293384_-|thioredoxin
MAGAIITVTDADFEEKVLNSDKPVLVDFWAEWCGPCRQVAPSLEAIAAEHDEILIAKLNIDQNPETTTKYGVMSIPTMNVYQGGEVAKTIVGAKPKAAIERDLADFLAAKG
>NC_016111.1|WP_014143862.1|3292338_3292956_+|GNAT-family-N-acetyltransferase
MGRRLVPLTLDNLPDLPKRCRSCVFWELDPVSGEAATQAGKPELEKEAWISAVLLEWGSCGRVVYVDDVPAGFVLYAPPAYVPRSTAFPTSPVSPDAVQLMTSRILPGFQGQGLGRVLVQTVAKDLVRRGFKAIEAFGDAHWEEPSCILPADHLTAVGFKTVRPHPRFPRLRLVLRSTLSWREDVEMAIDRLLGAVQKEPALRPL
>NC_016111.1|WP_157894833.1|3292181_3292334_+|hypothetical-protein
MKHEWRPAALVAAGLGLGAMGGFLVGLLRDRGTLKDAGFSKSCMVTKARA
>NC_016111.1|WP_041824753.1|3290870_3292007_+|ParB/RepB/Spo0J-family-partition-protein
MTERRRGLGRGLGALIPAAPTGAEPGPAVGAPVTSPSAVPVLTAERGVAAAKVAGLTESGVRTADPAPQIPVSRETEAPSPKKAEPEPALNEVVGAHFAEIPLDAIVPNPRQPRAYFDEDALDELVTSIKEVGLLQPVVVRETGPGSYELIMGERRWRACREAGLKRIPAIVRATEDEKLLLDALLENLHRAQLNPLEEAAAYDQLLKDFRCTHEELADRIGRSRSQVSNTLRLLKLSAPVQSKVAAGVLSAGHARALLGLDDVEAQDRLARRIVAEGLSVRSVEEIVNVMASAAKSAKRSKGPRAGKRLSPALSDLASRLSDRLDTRVKVDLGQRKGKIVVEFASIEDLERILGSIAPGEGKVLQKGLAAETEDPAS
>NC_016111.1|WP_078590746.1|3289782_3290874_+|AAA-family-ATPase
MAGSEHCEPPAEESESLRPDASTAGPMTDPVPGPRSETTAEDVSRETLPPMDDTPIGRAAQMAVEALGRAGEGLPRPEETRVIVVANQKGGVGKTTTTVNIAASLALHGGRVLVVDLDPQGNASTALGIDHHAEVPSIYDVLVESKPLSDVVQPVRDVEGLFCAPATIDLAGAEIELVSLVARESRLQRAIAAYEQPLDYILIDCPPSLGLLTVNALVAGAEVLIPIQCEYYALEGLGQLLRNVDLVRGHLNPKLHVSTILLTMYDGRTRLAAQVADEVRSHFGKEVLRTSIPRSVRISEAPSYGQTVLTYDPGSSGALSYLEAAREIALRGAGISVGYEAQEAHIARQNNEYGQHTMSEGIK
>NC_016111.1|WP_078590744.1|3288738_3289500_+|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG
MTASEGTVPVTEAAELPPAPEEARAVFGERFADAVRYAELLADAGVRRGLIGPREVPRLWARHLLNCAVLSDVVPKGVSVCDVGSGAGLPGIPLALARPDLRITLLEPLLRRTTFLQEVVDLLGLENVTVVRGRAEEMIGHLQPVDVVTARAVAPLDRLAGWGLPLLRPHGEMLALKGDTAEEELTHARAALDRLGAVDTSVVQAGVGLVDPPSTVVRVLVGESPGGVRAAARRARVARANRPVRSGGGRRRR
>NC_016111.1|WP_014143869.1|3300404_3302825_-|membrane-protein
MRDAAKHPGTTSLPACLPAGNTAARSGPAPRPPVRRGRLRRVAALLLGAALLALPAQLPGASRAQAAPSRTESAHGSAAAVSIDSLAPAVPGKSDTLQISGTVANTGDETITGGHVGVRVGGGGPLGSRSAITDTSSDDDFNPGADGPEVSGHTTKLADIPAGVSVPFTLSVPVSALGLGSDGVYQLGVTASGTTRDTGYDHVLGIERTFLPWYAQGGGQKTGTAFLWPLIDRPHLDIRPPGDNQQAPLFRDDDLASELAPGGRLDELVSLGKDLPVTWVVDPDLLASVDAMTKPYRVLGADGDPKRTTPGTGSDYAKRWLDELQTAVKGHEVVALPFGDPDIAAIAHHGKDVSGTIGHLKAATDLASVTVQTVLGVTPRTDFAWPAEGAVDPSIIGVATAAGADKVIARSDSLHETELNYTPTAARPIGGGTTAVVADAGLSKAFTGDMTRAGSVTSAVQRFLAQSLMITEQEPQRQRSIVVAPQRMPTTGQAQAMAAAIGALRSGTWVEPAGLGAAAAATPDPGANRSVPGGDSYPGALRGQELGTDAFQQIQSVQESLDGFEVILSRKDRVTTPFGNAVLRAMSTQWRGAGAQAAAFRNDVSAYLSDLRQDVRISDKDSITLSGRSAIIPVTVQNSLAQQVTGLELRLTSAQPNRLSVGKPQNVDIDGGHNRSLKFATTARANGKAWISAQLYTRDGAPYGEAMVFQVNVTSITDTVMLVIAGGLLLLVLAGVRMYRQRKRLAQRRAEEEGGGDAPATGDAPAPAPDDAAGDEPTRPEQPGDPAPDTAAGEAGPSEPGEKVDR
>NC_016111.1|WP_014143870.1|3303058_3304507_+|CCA-tRNA-nucleotidyltransferase
MAPAEASALNQVQRRAVGELLRVSPVADDLGRRFEQAGFRLALVGGSVRDALLGRLGNDLDFTTDARPEQVLKILRGWADAVWEVGIAFGTVGCRKADAAGNDFQIEVTTYRSEAYDRDSRKPEVSYGDTIEEDLVRRDFTVNAMAVSLPGIEFVDPHNGLEDLARRVLRTPGTPQESFSDDPLRMMRAARFAAQLDFDVAPEVVAAMTEMADRISIVSAERVRDELNKLVCGAYPRKGLQLLVDTGLADRVLPELPALRLERDEHHRHKDVYEHTLTVLEQAIALEESGPDPVLRLAALLHDIGKPKTRRFEPDGRVSFHHHEVVGAKLTKARMTKLKYPNDEVKAVSRLVELHLRFHGYGSGEWTDSAVRRYVRDAGPLLERLHKLTRSDCTTRNKKKAAALARTYDSLEARIAQLKEQEELDAIRPDLDGNEIMEILGVPAGPVVGKAYKHLLELRLENGPMAHDEAVAALKEWWAGQR
>NC_016111.1|WP_014143871.1|3304606_3305947_-|MFS-transporter
MAVIEDLRALLRFPDFRRLLAARLLSQLADGVYQVALAAYVVFSPEKQASPGAIAAAMAVLLLPYSLLGPFTGVLLDRWRRRQVLLHGNLLRSVLAAGTAVLVLVHVPDVFFYLSALSVTAVNRFVLAGLSAALPRVVDGDRLVVANSLCPTVGTIAATVGGAAAFAVHLVLRPGPGSDAAVVVLAAVIYLFAGLSARALDPDRLGPDPELLRPRLAGAVAGTVRGLVAGLRHLAARPQAARALAAMTVLRFAYGALFVTLLMLARNAWSPPGNASGGLALLGLAVGVSGAGFFAAAVITPWATTRCGTTGWITVCAAAAAVLEPCLGLPFEPAPMLVAAFLLGAATQGAKIATDTVLQAEVDDAFRGRVFALYDVTFNAAFVAAAALAALLLPPDGRSPALLLLVAAVYVAVAVTMARFVRQGARRAAPEAEPRQAEWEPEERAG
>NC_016111.1|WP_014143872.1|3306140_3307223_-|inositol-3-phosphate-synthase
MGSVRVAIVGVGNCAASLVQGVEYYKDADPDSRVPGLMHVQFGDYHVRDVEFVAAFDVDAKKVGLDLADAIGASENNTIKICDVPPSGVTVQRGHTLDGLGRYYRETIEESAEEPVDVVQILKDRQVDVLVCYLPVGSEEAAKFYAQCAIDAKVAFVNALPVFIAGTKEWADKFTEAGVPIVGDDIKSQVGATITHRVMAKLFEDRGVVLDRTMQLNVGGNMDFKNMLERDRLESKKISKTQAVTSQIPDRDLGAKNVHIGPSDYVAWLDDRKWAYVRLEGRAFGDVPLNLEYKLEVWDSPNSAGVIIDALRAAKIAKDRGIGGPVLSASSYFMKSPPVQYFDDEARENVEKFIRGEVER
>NC_016111.1|WP_014143873.1|3307276_3307906_-|helix-turn-helix-transcriptional-regulator
MSRRSGVLEFAVLGLLRESPMHGYELRKRLNTSLGVFRAFSYGTLYPCLKALVSQGWLVEEPPADEPGTAAPLAGRRAKIVYRLTAAGKEHFENLLAQTGPEAWEDEQFGVRFAFFGHTERDVRMRVLEGRRSRLEERLEKMRASLARTRERLDDYTLELQRHGMESVEREVRWLNELIETERAGRDRAKGRPADDQGRDDTDPTDTTN
>NC_016111.1|WP_014143874.1|3308309_3311177_+|penicillin-binding-protein
MSEHRRKPPQPNGSGRAADRRGAPPPGNGHRGAPPGRGADGYGTGAPSGPDRSYGSAPSPGSGPSYGGGSPYGSAPGGEGRAARRRAAGSEAGTASEGVPERPYGGRAEARRAAKGGRRAAGGAGSRGGGGRRGTGGGGSGPGGQGPGGQRPKRFIDYPRWGKTGWRRWMPSWKQVSAICVAFLGTLVGLVGIAYAMVDVPNPNAAAKQQKNVYYWADGSRMVVAGGGDYNRQIVPLDKISIHMQNAVISMENASFYHDAGVDPQGILRAILRMAQGGETQSGSTITQQYVKNTYLDQSQTLTRKFKELLISVKVGATVDKKDILAGYLNTAFYGRGAYGIQAASQAYYGVDADKLKPDQAAFLAAVLNGPNLYDPAGGIGDGATPEENTKRAVQRWNEVLDREVKTGDMTQQERAKYTKFPMPQKPKRSTDKAGQIGYLTDLANKYILNNTNISQHNLDNGGYQIHTTFDKNKVRALQQAVDSVRKKNLKPDVRSADKYVQFGGASVVPGDGAIVAIYGGEDYLKHFTDNADYTGAQVGSTFKPFVLAAAMQDGVRNPSLGPDQGPSERTKVSLKSMYTGLNKWKVLNYNRTVWQDPDGKEWLQVNDDNESIPTVDLKTAMAQSLNSTYAQLGMDVGMDKVRQAAITAGLQDDQSMVSTNGPSFSLGVSSPSAIRMADAYGTFAHGGVQADPYSVTRVEYQGTVKYQHETKTKQAFDPAIAGNVTDALQAVVQEGTGTAAKALGRPAAGKTGTTDDNKSAWFTGYTPELATSIGMYRMDDHATNPTFLKMYGVGGLDKIYGASFPTQIWTEYMKDALAGKPVQDFPPASAYGTVVHGPGATESAPPSAPPSNSPSVTPSAPPSKSPSHSPSPSITPTPTHSSCGLFGCEPGGTTTGTGSNNGNENGGPGSNTGTTNGAGNAGTTSGTGSSRGNGNGGPGGNGNGNGNGGGGIFG
>NC_016111.1|WP_106433127.1|3311317_3312841_+|DUF2029-domain-containing-protein
MSAMTTARKNAESAAAAPSTPPTWDDPVARAGSELLGGPAGRRMGAVAGRWWNPLRVIVLAAVGLFALGMVQKLPCYDSGWFFGANDQYTHACYSDIPHLFYARGFADDVVPYFGHIPDKVSGGMPYLEYPVLTGLFMEIASWFTPHGADLIRREQIYWLVNSGMLLVCAVVTVVAVARTHRRRPWDGLLVALAPAAALTATVNWDLLALALTAVGMLLWARRRPVASGVLIGLATAAKLYPALLLGPLLLLCLRAGRMRAFTKALAGAVVAWLVVNVPVMLAHDATGFHIRPGWAQFYSYSQTRPVDFGSLWLLISQQTGNPLPDANTYAIVLMLLLCAGLAWLVLYAPRRPRFAQTAFLVVAAFVLTNKVYSPQYVLWLVPLAALARPRWRDFLVWQAGEVMYFLGIWMYLAFTTGGNNKGLPEGGYDLAIALHLLATGYLCACVVRDILRAEHDPVRQDGSDDPSGGVLDGAPDVFVLGTAGARHAARSSGTAVRWGTPPDQAA
>NC_016111.1|WP_014143876.1|3313012_3314044_-|alanine-racemase
MALTLYVDTARWRAHHKTVVDQFPGIIPVCKGNGYGFGHERLAEETARLGADMIAVGTTYEAARMKDLFGGDLLVLTPYRLGEEPVPLPDRAIRSVSSVEGVRGLVGARVIVEVMSSMRRHGVLPEELGRLRGAIEDVRLEGFAIHLPLDRTDGSDGVQEVHGWMERLRAAGLPLHTMFVSHLKADELVHLQRQFPQTRFRTRIGTRLWLGDHQATEYRGAVLDVTRVGKGERYGYRQQKAAGEGHLVVVAGGTSHGVGLESPKAVHGVMPRAKGVARAGLATVNRNLSPFVWAGKQRWFAEPPHMQVSILFLPGDVAPPQMGEELVAHLRHTTTQPDRMVDR
>NC_016111.1|WP_014143877.1|3314100_3315219_-|peptidoglycan-bridge-formation-glycyltransferase-FemA/FemB-family-protein
MSLTLRTISREQHLAYIQSLPSASHMQVPAWADVKAEWRSENLGWFDKNGELVGVGLVLYRQLPKIKRYLAYLPEGPVINWYAPNLEEWLQPMLAHLKRQGAFSVKMGPPVVIRRWDAAAVKNGIADPDAKRLRDVEATFIEPRAFEVADRLRKMGWQQGEDGGAGFGDVQPRYVFQVPLEGRTLEDVHKGFNQLWRRNIKKAEKAGVEVVQGTYEQLPIWQQLYEITAERDHFRPRPLSYFQRMWTALNSEDPNRMRLYFAVHEGEAVAAATMLVVGGHVWYSYGASANHKREVRPSNAMQWRMLRDAYALGATVYDLRGISDSLDENDHLFGLIQFKVGTGGQAAEYLGEWDFPLNKLLHKALDIYMSRR
>NC_016111.1|WP_014143878.1|3315338_3315656_-|hypothetical-protein
MAQTFRQFRQRHVLTLNTDGRPHPVENTLTVITVVLGAVAALTSLSRGLHLVSSWTGLLGIVSGAYGQYISATTAERFLLVIGLGAAAVGFFIGMAHGGLFGGVV

Crispr_ID: NC_016111_7

• CRISPR_ID: NC_016111_7
• CRISPR_location: 4716920-4717121
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NC_016111_7

Consensus_repeat	Method
GCCGGTCGGCCGGGTGCGGCCGGGA	CRISPRCasFinder
CGTCGGCCGGGTGCGGCCGGGACACGCCGCCGTGCGG	PILER-CR

spacers of NC_016111_7

>7.1|4716945|49|NC_016111|CRISPRCasFinder
AACGCCGCCGCGTGGGGGGGGCGGCTGTGCCGCGTCGGTGGCGGGCGCT
>7.2|4716961|37|NC_016111|PILER-CR
GGGGGGCGGCTGTGCCGCGTCGGTGGCGGGCGCTTGC
>7.3|4717035|51|NC_016111|PILER-CR
GATCGCGTGTCCACGCGGGCGCCGCCGGCAGTGCCGTGCGTAACGGGCGTG

CRISPR arrays and Neighbor proteins around NC_016111_7

CRISPR arrays

The CRISPR arrays of NC_016111_7

>merge|NC_016111|7|4716920-4717121|CRISPRCasFinder,PILER-CR
GCCGGTCGGCCGGGTGCGGCCGGGAAACGCCGCCGCGTGGGGGGGGCGGCTGTGCCGCGTCGGTGGCGGGCGCTTGCCGTCGGCCGGGTGCGGCCGGGACGCGGCGCAGTGCGTGATCGCGTGTCCACGCGGGCGCCGCCGGCAGTGCCGTGCGTAACGGGCGTGCGTCGGCCGGGTGCGGCCGGGACACGTTGCCGTGCGG

>NC_016111|7|7|4716920-4717018|CRISPRCasFinder
GCCGGTCGGCCGGGTGCGGCCGGGA	AACGCCGCCGCGTGGGGGGGGCGGCTGTGCCGCGTCGGTGGCGGGCGCT
TGCCGTCGGCCGGGTGCGGCCGGGA

>NC_016111|7|2|4716924-4717121|PILER-CR
GTCGGCCGGGTGCGGCCGGGAAACGCCGCCGCGTGGG	GGGGGCGGCTGTGCCGCGTCGGTGGCGGGCGCTTGCC
GTCGGCCGGGTGCGGCCGGGACGCGGCGCAGTGCGTG	ATCGCGTGTCCACGCGGGCGCCGCCGGCAGTGCCGTGCGTAACGGGCGTGC
GTCGGCCGGGTGCGGCCGGGACACGTTGCCGTGCGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016111.1|WP_014145121.1|4725462_4725873_-|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|224647
NC_016111.1|WP_014145117.1|4721557_4722691_+|hypothetical-protein	unknown	unknown	gnl|CDD|349951
NC_016111.1|WP_014145113.1|4717409_4719617_+|ATP-dependent-DNA-helicase-RecG	unknown	unknown	gnl|CDD|236794
NC_016111.1|WP_014145104.1|4708916_4709672_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl|CDD|153251
NC_016111.1|WP_014145109.1|4712862_4713828_+|thiamine-phosphate-kinase	unknown	unknown	gnl|CDD|235583
NC_016111.1|WP_014145116.1|4720914_4721427_+|pantetheine-phosphate-adenylyltransferase	unknown	unknown	gnl|CDD|234674
NC_016111.1|WP_014145114.1|4719748_4720267_+|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_014145112.1|4715243_4716884_+|DAK2-domain-containing-protein	unknown	unknown	gnl|CDD|274671
NC_016111.1|WP_014145120.1|4724573_4725452_+|bifunctional-DNA-formamidopyrimidine-glycosylase/DNA-(apurinic-or-apyrimidinic-site)-lyase	unknown	unknown	gnl|CDD|234899
NC_016111.1|WP_041824911.1|4723497_4723671_+|50S-ribosomal-protein-L32	unknown	unknown	gnl|CDD|237038
NC_016111.1|WP_014145119.1|4723690_4724479_+|ribonuclease-III	unknown	unknown	gnl|CDD|234633
NC_016111.1|WP_014145108.1|4712410_4712644_-|Lrp/AsnC-ligand-binding-domain-containing-protein	unknown	unknown	gnl|CDD|366431
NC_016111.1|WP_106433144.1|4708034_4708697_-|2-phospho-L-lactate-guanylyltransferase	unknown	unknown	gnl|CDD|274643
NC_016111.1|WP_014628430.1|4710713_4711862_+|D-alanine--D-alanine-ligase	unknown	unknown	gnl|CDD|234993
NC_016111.1|WP_014145107.1|4711895_4712390_-|DUF3515-domain-containing-protein	unknown	unknown	gnl|CDD|378794
NC_016111.1|WP_014145118.1|4722835_4723495_+|DUF177-domain-containing-protein	unknown	unknown	gnl|CDD|376863
NC_016111.1|WP_014145115.1|4720336_4720918_+|16S-rRNA-(guanine(966)-N(2))-methyltransferase-RsmD	unknown	unknown	gnl|CDD|367574
NC_016111.1|WP_014628431.1|4714808_4714994_-|50S-ribosomal-protein-L28	unknown	unknown	gnl|CDD|234736
NC_016111.1|WP_014145110.1|4713906_4714695_+|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	unknown	unknown	gnl|CDD|180561
NC_016111.1|WP_014145105.1|4709668_4710670_+|NAD(P)-dependent-glycerol-3-phosphate-dehydrogenase	unknown	unknown	gnl|CDD|234629

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016111.1|WP_014145121.1|4725462_4725873_-|helix-turn-helix-transcriptional-regulator	gnl|CDD|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	4.77821e-35
NC_016111.1|WP_014145117.1|4721557_4722691_+|hypothetical-protein	gnl|CDD|349951	cd06503, ATP-synt_Fo_b, F-type ATP synthase, membrane subunit b. Membrane subunit b is a component of the Fo complex of FoF1-ATP synthase. The F-type ATP synthases (FoF1-ATPase) consist of two structural domains: the F1 (assembly factor one) complex containing the soluble catalytic core, and the Fo (oligomycin sensitive factor) complex containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. F1 is composed of alpha (or A), beta (B), gamma (C), delta (D) and epsilon (E) subunits with a stoichiometry of 3:3:1:1:1, while Fo consists of the three subunits a, b, and c (1:2:10-14). An oligomeric ring of 10-14 c subunits (c-ring) make up the Fo rotor. The flux of protons through the ATPase channel (Fo) drives the rotation of the c-ring, which in turn is coupled to the rotation of the F1 complex gamma subunit rotor due to the permanent binding between the gamma and epsilon subunits of F1 and the c-ring of Fo. The F-ATP synthases are primarily found in the inner membranes of eukaryotic mitochondria, in the thylakoid membranes of chloroplasts or in the plasma membranes of bacteria. The F-ATP synthases are the primary producers of ATP, using the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts). Alternatively, under conditions of low driving force, ATP synthases function as ATPases, thus generating a transmembrane proton or Na(+) gradient at the expense of energy derived from ATP hydrolysis. This group also includes F-ATP synthase that has also been found in the archaea Candidatus Methanoperedens.	1.67923e-06
NC_016111.1|WP_014145113.1|4717409_4719617_+|ATP-dependent-DNA-helicase-RecG	gnl|CDD|236794	PRK10917, PRK10917, ATP-dependent DNA helicase RecG; Provisional.	0
NC_016111.1|WP_014145104.1|4708916_4709672_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl|CDD|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	2.77951e-40
NC_016111.1|WP_014145109.1|4712862_4713828_+|thiamine-phosphate-kinase	gnl|CDD|235583	PRK05731, PRK05731, thiamine monophosphate kinase; Provisional.	1.19831e-127
NC_016111.1|WP_014145116.1|4720914_4721427_+|pantetheine-phosphate-adenylyltransferase	gnl|CDD|234674	PRK00168, coaD, phosphopantetheine adenylyltransferase; Provisional.	1.23701e-98
NC_016111.1|WP_014145112.1|4715243_4716884_+|DAK2-domain-containing-protein	gnl|CDD|274671	TIGR03599, YloV, DAK2 domain fusion protein YloV. This model describes a protein family that contains an N-terminal DAK2 domain (pfam02734), so named because of similarity to the dihydroxyacetone kinase family family. The GTP-binding protein CgtA (a member of the obg family) is a bacterial GTPase associated with ribosome biogenesis, and it has a characteristic extension (TIGR03595) in certain lineages. This protein family described here was found, by the method of partial phylognetic profiling, to have a phylogenetic distribution strongly correlated to that of TIGR03595. This correlation implies some form of functional coupling.	2.6409e-141
NC_016111.1|WP_014145120.1|4724573_4725452_+|bifunctional-DNA-formamidopyrimidine-glycosylase/DNA-(apurinic-or-apyrimidinic-site)-lyase	gnl|CDD|234899	PRK01103, PRK01103, bifunctional DNA-formamidopyrimidine glycosylase/DNA-(apurinic or apyrimidinic site) lyase.	8.82117e-149
NC_016111.1|WP_041824911.1|4723497_4723671_+|50S-ribosomal-protein-L32	gnl|CDD|237038	PRK12286, rpmF, 50S ribosomal protein L32; Reviewed.	8.0342e-25
NC_016111.1|WP_014145119.1|4723690_4724479_+|ribonuclease-III	gnl|CDD|234633	PRK00102, rnc, ribonuclease III; Reviewed.	4.65481e-120
NC_016111.1|WP_014145108.1|4712410_4712644_-|Lrp/AsnC-ligand-binding-domain-containing-protein	gnl|CDD|366431	pfam01037, AsnC_trans_reg, Lrp/AsnC ligand binding domain. The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold.	2.65137e-07
NC_016111.1|WP_106433144.1|4708034_4708697_-|2-phospho-L-lactate-guanylyltransferase	gnl|CDD|274643	TIGR03552, F420_cofC, 2-phospho-L-lactate guanylyltransferase. Members of this protein family are the CofC enzyme of coenzyme F420 biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	4.89474e-42
NC_016111.1|WP_014628430.1|4710713_4711862_+|D-alanine--D-alanine-ligase	gnl|CDD|234993	PRK01966, ddl, D-alanine--D-alanine ligase.	0
NC_016111.1|WP_014145107.1|4711895_4712390_-|DUF3515-domain-containing-protein	gnl|CDD|378794	pfam12028, DUF3515, Protein of unknown function (DUF3515). This family of proteins is functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 166 to 214 amino acids in length. This protein has a conserved RCG sequence motif.	1.33123e-13
NC_016111.1|WP_014145118.1|4722835_4723495_+|DUF177-domain-containing-protein	gnl|CDD|376863	pfam02620, DUF177, Uncharacterized ACR, COG1399. This family is nearly universally conserved in bacteria and plants except the Chlorophyceae algae. Thus far, mutantional analysis in bacteria have not established a function. In contrast, mutants have embryo lethal phenotypes in maize and Arabidopsis. In maize, the mutant embryos arrest at an early transition stage.It has been suggested that family members specifically affect 23S rRNA accumulation in plastids as well as bacteria.	1.94378e-27
NC_016111.1|WP_014145115.1|4720336_4720918_+|16S-rRNA-(guanine(966)-N(2))-methyltransferase-RsmD	gnl|CDD|367574	pfam03602, Cons_hypoth95, Conserved hypothetical protein 95.	5.9465e-66
NC_016111.1|WP_014628431.1|4714808_4714994_-|50S-ribosomal-protein-L28	gnl|CDD|234736	PRK00359, rpmB, 50S ribosomal protein L28; Reviewed.	4.67457e-24
NC_016111.1|WP_014145110.1|4713906_4714695_+|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	gnl|CDD|180561	PRK06427, PRK06427, bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed.	1.84589e-125
NC_016111.1|WP_014145105.1|4709668_4710670_+|NAD(P)-dependent-glycerol-3-phosphate-dehydrogenase	gnl|CDD|234629	PRK00094, gpsA, NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.	9.9947e-180

Protein sequences

>NC_016111.1|WP_014145112.1|4715243_4716884_+|DAK2-domain-containing-protein
MPPTLDAVAVRTWCRLALAELGRAREEIDAINVYPVADGDTGTNLYLTVESAAQSVDAVFDGHASSGARPDRAQTVRAMAHGALIGARGNSGTILAQLLRGMSEILAAPQPPRPDDADTLRRALRHAAASAHQAVAHPAEGTMLTVAAAAADAACATAGDVAAAARAAYDAACAALARTPGQLAALGRAGVVDAGGRGLVAVLGALARAVGATAQAPPATTARPLPDPRHDCAAGRDPHLAQDGPAFEVVYLLEAADSAVPALRARLDALGDCLVVVGGDGLWNVHVHVDDAGAAVEAGVDAGRPYRIRITHFGDQCRTGRRTAALEQRAVVAVADGDGLAALYAGAGATVVPVPAGEPLASGDLAAAVRRAHAREVVLLPNDAELLHLAGVAAEQARADGLRVALIPTRSAVQGIAALAVHQPSRRFDEDVVAMTAAAGATRYAAVAVAERESWTMAGVCQAGDLLGLIDGDVVVIGDDLARTAVTVLDRMLAAGGEMVTLVPGAGAPPGLADHLTDHVREHHLAVDTVVHPGGQHTCPLVIGVE
>NC_016111.1|WP_014628431.1|4714808_4714994_-|50S-ribosomal-protein-L28
MAANCDVCGKGPGFGNNISHSHRRTRRRWNPNIQTVRAVVGRTPKRLNVCTSCIKAGKVAR
>NC_016111.1|WP_014145110.1|4713906_4714695_+|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase
MRIPPRVLTVAGSDSGGGAGIQADLKTMLALGTHGMSVVTAVTAQNSLGVQGAWELPAEAVRAQFRSIVDDIGVQAVKTGMLASPELVRTVARLLAGVDAPVVVDPVGVSKHGDRLLAAEALESVRERLLPTATVATPNLDEVAELTGVKVTDEDGMREAARAILAYGPRWALIKGGHLPGAPVDLLSDGREEHWFRGARHDNRHTHGTGCTLASAIAAHLAKGLDVPQAVGAAKAYVTGAIAAGFPLGAGIGPVDHAWQWG
>NC_016111.1|WP_014145109.1|4712862_4713828_+|thiamine-phosphate-kinase
MKGTVGELGEFGLIRELTSRLTTTPAVRLGPGDDAAVVAAPDRRVVASTDVLLEGRHFRRDWSTAYDVGRKAAAQNLADIAAMGATPTALLLGLVVPAELPATWPLELMDGISDECQVAGAAVAGGDVVRGDAITVAITALGDLQGRRPVTRSGARPGDVVAVTGWLGWSAAGYALLSRGFRSPRAFVEAHRRPEPPYAEGPAAAALGATAMTDVSDGLLADLGHIAEASGVSIDVKRAALDVPAQMTDIGQAVGVDPVDWVLTGGEDHAIVAAFPAKAKLPARWRVIGEVLGAGAGPQVTVDGAVWEAAGGWDHFGAPAG
>NC_016111.1|WP_014145108.1|4712410_4712644_-|Lrp/AsnC-ligand-binding-domain-containing-protein
MVQAYILIQTEVGKATVVAEVISKLPGVLTAEDVTGPYDVIVRAQADTVDELGRMVVAKVQQVDGITRTLTCPVVHL
>NC_016111.1|WP_014145107.1|4711895_4712390_-|DUF3515-domain-containing-protein
MNVFVPARLRPLLPLPATVLLTVAGCSSGPANAVAVPSPSPSAAAICRALHDRLPGTVDGLARHATTPASPFTAAWGNPQVELRCGVPRPRSLTPGDPHYDPTAEAVGVNDVTWLPQQFDGGYRFTTTGRAAFVEVTVPSAYKPEVNPLTDLAAAVKRADPTEL
>NC_016111.1|WP_014628430.1|4710713_4711862_+|D-alanine--D-alanine-ligase
MPSHHSRPPSGRKPRVAVVFGGRSSEHAISVVTAGAVLRAIDRTKYDVLPIGITTDGRWALAADEPDRMAITAGQLPDVARLAESAEGSVVLPVDPASREVVLSEPGSVPKALGEVDVVFPVLHGPYGEDGTLQGLLELSGVPYVGAGVLASAVGMDKEYMKRVFTSFGLAVGPYLVIRPREWHADPAAARRRITDFAEREGWPLFVKPARAGSSMGISKVDGPDELDAAVELAQSHDPKILVESALSGREIECGVLEFEDGPRASVPAWIPPADAHGFYDFEAKYIDSAEGVVPAPLTDEETARVRELAVRAFDAVSCEGLVRADFFLTDDGEFVINEVNTMPGFTPISMYPRMWEATGVDYPELVDRLIQAALRRSTGLR
>NC_016111.1|WP_014145105.1|4709668_4710670_+|NAD(P)-dependent-glycerol-3-phosphate-dehydrogenase
MTRCAVYGTGSWGTAFAMILADAGCEVTMWGRRPALAETINTTRINPDYLPGVALPPSVTATTDPARAAEGAEFVVLAVPSQTLRENLAAWAPLFPADAVLVSLMKGVELGTKKRMSEVIEEVAKAAPERVAVLSGPNLAGEIAARQPAAAVVACRDEEVARRLQSACHTAYFRPYTNTDVVGTELGGAVKNVIALAVGIAEGMGLGDNAKASLITRGLAETTRLGLAMGADAHTFAGLAGMGDLVATCASPLSRNHTFGINLGRGMTLEETVAVTKQTAEGVKSCRSVLDLARDMGVEMPITETVVGIVHQGKPPLVALKELMSRSTKAERR
>NC_016111.1|WP_014145104.1|4708916_4709672_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MSRRRIGFWYRLAAVIVKPWLIVLFKRDWRGMENIPADGGFITAINHNSYLDTFSYAHFQYNTGRVPRFLAKDALFRKGVAGAFMRGTDQIPVYRESVNAAGAFRAAVAAIERGECVAFYPEGTLTRDPGLWPMTGKTGVARVALLTRAPVIPIAQWGANEALPPYGKPRLLPRKTLRVVAGPPVDLSAYYDQEPTPEVLRAATGTIMDAITGLLEELRGERAPAERYDMRKAREEERRRADRAAEREESK
>NC_016111.1|WP_106433144.1|4708034_4708697_-|2-phospho-L-lactate-guanylyltransferase
MWDLVVPLKPLTVAKSRLRGAAAAGVVVRPPLALAFAQDTVAAALACPAVAGVTVVTDDPLAAPELAALGARVFPDAPGGGLNAALTHGARLVRAERPGASVAALNADLPALRPAELARALSVAGRARRAFVADAAGLGTTLLTASRGTDLSPAFEGPSRARHLASGAREIRLPDIDSLRRDVDTPADLRIALSLGVGPHTTTATTGIFAKGGAFAEHPE
>NC_016111.1|WP_014145113.1|4717409_4719617_+|ATP-dependent-DNA-helicase-RecG
MAALDEPLRKVVGDRTAKVLADHLDLHTTGDLLHHYPRRYAERGELTRLADLPLDEHVTVVAQVAKAEKKTYNRGAGVRLEVVVTDGSGSLQLVFFNKAAHFHHTKLVPGRRGMFAGKVTVFNRVRQLAHPDYQLLDAEDGEEAVDAFAGRLLPLYPACKQIASWQIAQAVDVVLDSLTGTEWAGVADPLPARLRADRGLAPLPEALLKVHRPATRADIADARERLKWDEAFVLQVALARRRADDAARPAVARRPKDDGLLTAFDARLPFTLTEGQTKVSAEIFADLAAEHPMHRLLQGEVGSGKTLVALRAMLAVVDSGGQAAMLAPTEVLAQQHHRSITEMMGDLAEGGMLGGADVGTKVVLLTGSMGAAARRQALLDLVSGDAGIVVGTHALIEDKVTFHDLGLVVVDEQHRFGVEQRDALRGKGNRPPHLLVMTATPIPRTVAMTVFGDLETSVLDQLPAGRSPIATHVVPAKDKPHFLTRAWERVREEVAAGHQGYVVCPRIGDEEEPAKAKETKEGKEAADDAERRPPLAVLDVAEQLATGPLAGLRVEVLHGRMQPEAKDDVMRRFAAGQVDVLVATTVIEVGVNVPNATAMVIMDADRFGVSQLHQLRGRVGRGAAAGLCLLVTEAPEVSPARTRLDAVAATLDGFELSRIDLEQRREGDVLGQAQSGTRSSLRMLTVIADEDIIAAAREEATALVAADPSLAGHPELRSALDSLVDASREDYLEKG
>NC_016111.1|WP_014145114.1|4719748_4720267_+|hypothetical-protein
MAFRHINELPLGEKVFRIELASEDDTTVTVTLSGWHESDPDTLLASGELRLPLQDVASLRLAVNRALRAIALVADVAEPIPDRDVLRELYPGHGAPWVPQHEQELVRRFHDGETVARISARFGRTPDSVRTKLRELGHDPRRPEYCPPDGCLSWSRYASPALVGAAEEPGRG
>NC_016111.1|WP_014145115.1|4720336_4720918_+|16S-rRNA-(guanine(966)-N(2))-methyltransferase-RsmD
MTRVIAGAAGGRRLAVPPGQGTRPTSDRAREGLFSTWQALHGPLTGARVLDLYGGSGAVGLEALSRGAAHVLLVEADARAVRVIRENVRALGLPGAEVRAAKAEKVVAGPPPADPYDVVFLDPPYAVSDDELREILITLAAGGWLAADAMVTVERGTRGGQFHWPAGFEGLRARRYGEGTLWYGRAAQVTDAS
>NC_016111.1|WP_014145116.1|4720914_4721427_+|pantetheine-phosphate-adenylyltransferase
MTHPESEESPLRRAVCPGSFDPITNGHLDIIARASRLYDVVHVAVMINKSKQGLFTIDERISLIEQVTAEFGNVRVESFHGLLVDFCKQREIPAIVKGLRAVSDFDYELQMAQMNNGLSGVETLFVPTNPAYSFLSSSLVKEVAAWGGDVSHLVPAPVMEALRGKLGKDR
>NC_016111.1|WP_014145117.1|4721557_4722691_+|hypothetical-protein
MDVQKKLDEIVAAVEGARSMPMSASCVINRAELLAMVRDLQAALPEALSRAEAVIGDREQVVAEARAEADRVIAAAHEERAALISGTEVARHAQEEADRLLAEARAEADEVRAEADEYVDSKLANFEVVLTKTLGSVDRGREKLLGRDPGASPAEQADPEYDAAPERTSDPDELRRRADAYVDAKLGAFEAVLAKTLEAVGRGRQKLTGHRPIDDLAAHLAAQDALGAAPQSDDEYLAGLAAGLNQTPVAPAVPAPSQPGDYGYPQQPGYAPAAAGYEGTGYQDPSLGYGTTAEPQHPGYQGYYGTYQEQPGGYGDWPAHHGYQEAVGQAPAPQTHPQQPQGAHAHVPQQPAGLDETSFFDTSLIDLNQLRELDGGR
>NC_016111.1|WP_014145118.1|4722835_4723495_+|DUF177-domain-containing-protein
MHRGKQEAINARLDHRDPLVLDTRELGRRPGAMKRIARTVPAPADLGVADVIGVPASAEIELDLRLESVMEGVLVTGTARAPVTGECVRCLEPIERELETDFQELFSYPDAGEGFGGHADEADGDEEEELLQVEDDLIGLEPVLRDAVVLELPLQPVCREDCPGLCADCGARLADDPGHHHDATDIRWAALQGLADSLQGGEKDNMSGAEGGVDEKQEK
>NC_016111.1|WP_041824911.1|4723497_4723671_+|50S-ribosomal-protein-L32
MAVPKRKMSRSNTRHRRSQWKAAPVTLVACERCHEPKQQHIACPSCGTYNKRQVLEV
>NC_016111.1|WP_014145119.1|4723690_4724479_+|ribonuclease-III
MSDADRSPHKRGGDPAQADTASSHTLLEGRLGYTLEPALLVRALTHRSFAYENGGLPTNERLEFLGDSVLGLVVTDTLYRVHPDLPEGQLAKLRAAVVNSRALAEVARGLELGRFVRLGRGEEGTGGRNKASILADTLEAVIGAVYLDQGLDAASELVHRLFDPLIEKSSNLGAGLDWKTSLQELTATEALGVPEYLVTESGPDHEKTFTAAARVGGVTYGTGTGRSKKEAEQQAAEAAWRAIGAKRDAAAKAAGSAEPAAS
>NC_016111.1|WP_014145120.1|4724573_4725452_+|bifunctional-DNA-formamidopyrimidine-glycosylase/DNA-(apurinic-or-apyrimidinic-site)-lyase
MPELPEVEVVRRGLERWISGRTVAEVTVLHPRAVRRHPAGAEDFASRLRGTVLGPARRRGKYLWLLLDDGGSLLGHLGMSGQLLVQPLDAPAETHLRVRIRLADDLGTELRFVDQRTFGGLSVHPCVPDGPDAAVGLPLPLAHIAPDPLEAAFDEDAFHAALRRRRTTIKRALLDQSLISGVGNIYADEALWRSRLHYDRPTATLTRPRTAELVGHIREVMNEALAVGGTSFDSLYVNVNGESGYFDRSLDAYGREDEPCRRCGTAIRRRPWMNRSSYYCPRCQRPPRPTAG
>NC_016111.1|WP_014145121.1|4725462_4725873_-|helix-turn-helix-transcriptional-regulator
MDDATVTAPAPDEDIDLAYDVFARSCPSRHTLEHVTGRWGALTLGALSENTLRFNELRRRVDGVSEKMLSQTLHALERDGLVHREDRQTNPPRVEYRLTPLGESVAERLLSLIELIEGKMPEVLAAQHRYDGRRPA

Crispr_ID: NC_016111_8

• CRISPR_ID: NC_016111_8
• CRISPR_location: 4919210-4919311
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers
• Cas_protein_info: DinG

Consensus repeat of NC_016111_8

Consensus_repeat	Method
CCCGGGCCCTCGGGCGGGGCCGCG	CRISPRCasFinder

spacers of NC_016111_8

>8.1|4919234|54|NC_016111|CRISPRCasFinder
CTTCCGGGTACCGGCACCGGCGTGGCCCACGACGCGGGCCGGGGAACGGCCCGG

CRISPR arrays and Neighbor proteins around NC_016111_8

CRISPR arrays

The CRISPR arrays of NC_016111_8

>merge|NC_016111|8|4919210-4919311|CRISPRCasFinder
CCCGGGCCCTCGGGCGGGGCCGCGCTTCCGGGTACCGGCACCGGCGTGGCCCACGACGCGGGCCGGGGAACGGCCCGGCCCGGGCCCTCGGGCGGGGCCGTC

>NC_016111|8|8|4919210-4919311|CRISPRCasFinder
CCCGGGCCCTCGGGCGGGGCCGCG	CTTCCGGGTACCGGCACCGGCGTGGCCCACGACGCGGGCCGGGGAACGGCCCGG
CCCGGGCCCTCGGGCGGGGCCGTC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016111.1|WP_014145278.1|4923925_4925902_+|ATP-dependent-DNA-helicase	DinG	COG1199_DinG_CAS-IV-A	gnl|CDD|224120
NC_016111.1|WP_014628469.1|4906871_4907819_+|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	unknown	unknown	gnl|CDD|234626
NC_016111.1|WP_014145277.1|4922085_4923849_+|IucA/IucC-family-siderophore-biosynthesis-protein	unknown	unknown	gnl|CDD|226715
NC_016111.1|WP_014145272.1|4913648_4915163_+|GTPase-HflX	unknown	unknown	gnl|CDD|274455
NC_016111.1|WP_014145285.1|4932959_4933736_+|MBL-fold-metallo-hydrolase	unknown	unknown	gnl|CDD|225130
NC_016111.1|WP_041824925.1|4926058_4926829_-|transcriptional-repressor-LexA	unknown	unknown	gnl|CDD|234688
NC_016111.1|WP_014145284.1|4931548_4932793_+|3-phosphoshikimate-1-carboxyvinyltransferase	unknown	unknown	gnl|CDD|238797
NC_016111.1|WP_014145276.1|4921138_4921942_+|acetyltransferase	unknown	unknown	gnl|CDD|379237
NC_016111.1|WP_014145281.1|4927467_4928103_+|transcriptional-repressor-NrdR	unknown	unknown	gnl|CDD|234774
NC_016111.1|WP_014145265.1|4906458_4906686_-|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_014145273.1|4915247_4916480_-|hypothetical-protein	unknown	unknown	gnl|CDD|237605
NC_016111.1|WP_014145286.1|4933725_4935144_-|MFS-transporter	unknown	unknown	gnl|CDD|129794
NC_016111.1|WP_014145269.1|4908614_4909502_+|diaminopimelate-epimerase	unknown	unknown	gnl|CDD|234768
NC_016111.1|WP_014145268.1|4908003_4908552_+|hypothetical-protein	unknown	unknown	unknown
NC_016111.1|WP_014145271.1|4911926_4913495_+|M1-family-metallopeptidase	unknown	unknown	gnl|CDD|341066
NC_016111.1|WP_041824922.1|4909712_4911818_+|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	unknown	unknown	gnl|CDD|223394
NC_016111.1|WP_014145274.1|4916811_4918251_+|diaminobutyrate--2-oxoglutarate-transaminase	unknown	unknown	gnl|CDD|235892
NC_016111.1|WP_014145264.1|4906218_4906434_-|antitoxin	unknown	unknown	gnl|CDD|379416
NC_016111.1|WP_014145287.1|4935296_4935701_-|glyoxalase/bleomycin-resistance/extradiol-dioxygenase-family-protein	unknown	unknown	gnl|CDD|319925
NC_016111.1|WP_014145282.1|4928388_4931310_+|vitamin-B12-dependent-ribonucleotide-reductase	unknown	unknown	gnl|CDD|235828

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_016111.1|WP_014145278.1|4923925_4925902_+|ATP-dependent-DNA-helicase	DinG	COG1199_DinG_CAS-IV-A	5.2e-130	429.4	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016111.1|WP_014145278.1|4923925_4925902_+|ATP-dependent-DNA-helicase	gnl|CDD|224120	COG1199, DinG, Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair].	6.12143e-139
NC_016111.1|WP_014628469.1|4906871_4907819_+|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	gnl|CDD|234626	PRK00091, miaA, tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed.	2.88819e-148
NC_016111.1|WP_014145277.1|4922085_4923849_+|IucA/IucC-family-siderophore-biosynthesis-protein	gnl|CDD|226715	COG4264, RhbC, Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism].	4.1961e-169
NC_016111.1|WP_014145272.1|4913648_4915163_+|GTPase-HflX	gnl|CDD|274455	TIGR03156, GTP_HflX, GTP-binding protein HflX. This protein family is one of a number of homologous small, well-conserved GTP-binding proteins with pleiotropic effects. Bacterial members are designated HflX, following the naming convention in Escherichia coli where HflX is encoded immediately downstream of the RNA chaperone Hfq, and immediately upstream of HflKC, a membrane-associated protease pair with an important housekeeping function. Over large numbers of other bacterial genomes, the pairing with hfq is more significant than with hflK and hlfC. The gene from Homo sapiens in this family has been named PGPL (pseudoautosomal GTP-binding protein-like). [Unknown function, General].	1.02841e-169
NC_016111.1|WP_014145285.1|4932959_4933736_+|MBL-fold-metallo-hydrolase	gnl|CDD|225130	COG2220, COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only].	1.0635e-15
NC_016111.1|WP_041824925.1|4926058_4926829_-|transcriptional-repressor-LexA	gnl|CDD|234688	PRK00215, PRK00215, transcriptional repressor LexA.	1.70103e-115
NC_016111.1|WP_014145284.1|4931548_4932793_+|3-phosphoshikimate-1-carboxyvinyltransferase	gnl|CDD|238797	cd01556, EPSP_synthase, EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-phosphate (EPSP), an intermediate in the shikimate pathway leading to aromatic amino acid biosynthesis. The reaction is phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. It is found in bacteria and plants but not animals. The enzyme is the target of the widely used herbicide glyphosate, which has been shown to occupy the active site. In bacteria and plants, it is a single domain protein, while in fungi, the domain is found as part of a multidomain protein with functions that are all part of the shikimate pathway.	2.95394e-143
NC_016111.1|WP_014145276.1|4921138_4921942_+|acetyltransferase	gnl|CDD|379237	pfam13523, Acetyltransf_8, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	2.19877e-54
NC_016111.1|WP_014145281.1|4927467_4928103_+|transcriptional-repressor-NrdR	gnl|CDD|234774	PRK00464, nrdR, transcriptional repressor NrdR.	5.09521e-85
NC_016111.1|WP_014145274.1|4916811_4918251_+|diaminobutyrate--2-oxoglutarate-transaminase	gnl|CDD|235892	PRK06938, PRK06938, diaminobutyrate--2-oxoglutarate aminotransferase; Provisional.	0
NC_016111.1|WP_014145273.1|4915247_4916480_-|hypothetical-protein	gnl|CDD|237605	PRK14086, dnaA, chromosomal replication initiator protein DnaA.	0.00601687
NC_016111.1|WP_014145286.1|4933725_4935144_-|MFS-transporter	gnl|CDD|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	3.67124e-56
NC_016111.1|WP_014145269.1|4908614_4909502_+|diaminopimelate-epimerase	gnl|CDD|234768	PRK00450, dapF, diaminopimelate epimerase; Provisional.	3.03113e-109
NC_016111.1|WP_014145264.1|4906218_4906434_-|antitoxin	gnl|CDD|379416	pfam14013, MT0933_antitox, MT0933-like antitoxin protein. This family of proteins contains the MT0933 protein, which has been identified as an antitoxin to /protein MT0934. This family of proteins is found in bacteria. Proteins in this family are typically between 61 and 90 amino acids in length.	4.65473e-10
NC_016111.1|WP_014145271.1|4911926_4913495_+|M1-family-metallopeptidase	gnl|CDD|341066	cd09603, M1_APN_like, Peptidase M1 family similar to aminopeptidase N catalytic domain. This family contains mostly bacterial and some archaeal M1 peptidases with smilarity to the catalytic domain of aminopeptidase N (APN; CD13; alanyl aminopeptidase; EC 3.4.11.2), a type II integral membrane protease belonging to the M1 gluzincin family. APN preferentially cleaves neutral amino acids from the N-terminus of oligopeptides and, in higher eukaryotes, is present in a variety of human tissues and cell types (leukocyte, fibroblast, endothelial and epithelial cells). APN expression is dysregulated in inflammatory diseases such as chronic pain, rheumatoid arthritis, multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, polymyositis/dermatomyosytis and pulmonary sarcoidosis, and is enhanced in tumor cells such as melanoma, renal, prostate, pancreas, colon, gastric and thyroid cancers. It is predominantly expressed on stem cells and on cells of the granulocytic and monocytic lineages at distinct stages of differentiation, thus considered a marker of differentiation. Thus, APN inhibition may lead to the development of anti-cancer and anti-inflammatory drugs. APNs are also present in many pathogenic bacteria and represent potential drug targets. Some APNs have been used commercially, such as one from Lactococcus lactis used in the food industry. APN also serves as a receptor for coronaviruses, although the virus receptor interaction site seems to be distinct from the enzymatic site and aminopeptidase activity is not necessary for viral infection. APNs have also been extensively studied as putative Cry toxin receptors. Cry1 proteins are pore-forming toxins that bind to the midgut epithelial cell membrane of susceptible insect larvae, causing extensive damage. Several different toxins, including Cry1Aa, Cry1Ab, Cry1Ac, Cry1Ba, Cry1Ca and Cry1Fa, have been shown to bind to APNs; however, a direct role of APN in cytotoxicity has been yet to be firmly established.	1.9387e-134
NC_016111.1|WP_041824922.1|4909712_4911818_+|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	gnl|CDD|223394	COG0317, SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription].	1.91641e-154
NC_016111.1|WP_014145287.1|4935296_4935701_-|glyoxalase/bleomycin-resistance/extradiol-dioxygenase-family-protein	gnl|CDD|319925	cd07264, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	3.00608e-16
NC_016111.1|WP_014145282.1|4928388_4931310_+|vitamin-B12-dependent-ribonucleotide-reductase	gnl|CDD|235828	PRK06556, PRK06556, vitamin B12-dependent ribonucleotide reductase; Validated.	0

Protein sequences

>NC_016111.1|WP_014145274.1|4916811_4918251_+|diaminobutyrate--2-oxoglutarate-transaminase
MPTAEGRPSPPQGAAPADGPGVPGGADAILGRQAARESAARTYARSLPVVPVRARGMTIEGADGRRYLDCLAGAGTLALGHNHPVVLEAIRAVLDSGAPLHVLDLATPVKDAFTTALFETLPPELAENGRIQFCGPAGTDAVEAAVKLVRHATGRSGLLTFTGAYHGMTAVSLAAGGDTTARAAVGEADARITRLPYPYDYRCPFGVGGDRGAELSARWTATLLDDPKGGLQPPAGMLLEVVQGEGGVVPAPDAWLRRMRQLTKDRGIPLIADEVQTGVGRTGAFWAVEHSGIVPDVMVLSKAIGGSLPLAVVVYREELDTWHPGAHAGTFRGNQLAMAAGTATLRYVRENRLHERAARIGARMLTRLRGLAAHYPCVGDVRGRGLMIGVELVDPARPRDEYGALPAAPRLAAAVQAQALRRGLIVELGGRHGSVVRLLPPLTITDEQAEAVLDRLSDAIAAAERTAQHPGVIPGQGSA
>NC_016111.1|WP_014145273.1|4915247_4916480_-|hypothetical-protein
MPHPPATARRPQQPAPRAPRARRNRPAAWTAAAVTAALALTATACGPSDTKADGKPAATASAGQGQDGHHGLRLPSGFPTSLADLEKWKHGDWRKWDSWARRAADFANPVIKDLWKPRRMAEAKDRPVPQVPPNIGGDQGVSDPAPRPVQAVPVPTPYHRSAGPVGKIFFDTPQGSFVCSGTVVRDPAHPGRSNLVWTAGHCVHKGKAGGWYRNIVFVPSYNDDGLSAAAAASAPRQQVAPDGVWWADWAGTSRQWIDTGAESGGSGSPYDFAVLHVHPENGTGKSLEETVGAALPVWFDAPSATAISRMGAWGYPAAPPFDGARMFDCLDKPGRLSLDPSMPTEYRIGCTMTGGSSGGGWFAKRPDGTVALVSNTSIGPSDNTWLAGPHLGAEARSVFDAVSGRFAAAG
>NC_016111.1|WP_014145272.1|4913648_4915163_+|GTPase-HflX
MTNSTSSSSAARSAAADRQRLPESLRATALMEEDVAWSLDVDGERDGDQFDRSERASLRRVAGLSTELQDVTEVEYRQLRLERVVLVGVWTDGTVQDAENSLAELAALAETAGALVLDGVIQRRDKPDPATYIGSGKAQELRDIVLESGADTVVCDGELSPGQLIHLEDVVKVKVVDRTALILDIFAQHAKSREGKAQVALAQMQYMLPRLRGWGQSLSRQMGGGGSGSAGGGMATRGPGETKIETDRRRIREKMAKLRREIAEMKTSRDLKRQERRRHQVPSVAIAGYTNAGKSSLLNRLTGAGVLVENALFATLDPTVRRAETPSGRLYTLADTVGFVRHLPHHLVEAFRSTMEEVADADLVLHVVDGAHPVPEEQLAAVREVLRDVGAADVPEIVVINKADAADPLVVQRLLTHEKHAIAVSARSGEGVAELLALLDAELPRPRVEIEALVPYTHGALVSRVHVGGEVISEEHTAEGTLLKARVHDQLAAELGPFALAVQR
>NC_016111.1|WP_014145271.1|4911926_4913495_+|M1-family-metallopeptidase
MTRIAFRKATALAAAACAVLFTTAAQPQEPPRTGLGDRLYPALGDPRIHVGAYDITLDYHGNDKPLDAVTRMEARAVTGFDRFHLDFTHGTVRKVTVDGRPAAFRTTGEWLEITPGHHVEAGRPLRITVTHTSDPSGTDGQGGWVRTADGLALANQAVAAHHVFPCNDHPSDKAFFTFRITTPKGITAVAGGLPAGRPASGGTARAATTTWTYTTAHPVATELAQVSIGRSTVLHRTGPHGLPMRDVVPTADRTVLADRLALTPAQLSWMEGQVGPFPFETYGVLAVNTATGFELETQTLSLFERRLLVAPVAYVAPLMIHELAHQWFGDSVTPAAWSDVWLNEGHATWYEWRYRGEKKYGDSLDAQAKRAYQIDALARAAYGPPARPKVPPAGSKLGIFRENVYGGGALVLYALRHEIGDHAFRELERAWVTEHRDGNVTTHDFVALASRVAGRDLSGFLNGWLYGAKPPAMPGHPDWKPLTKLPVATALPGSPGAATRPGGRPAGRAQRPAPAVPAPVRR
>NC_016111.1|WP_041824922.1|4909712_4911818_+|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase
MDAVPAVSGGNERRRGLTRPTLRRLGRAALFGSAGGRDRLPDAIEHVAKVHRAHHPRADLDTLRRAYLLAESSHRGQLRKSGEPYITHPLAVTLILAELGAETTTLTASLLHDTVEDTDVTLEQVRAEFGEEVCYLVDGVTKLEKVDYGAAAEPETFRKMLVATGNDVRVMSIKLADRLHNMRTLGVMRPEKQARIAKVTRDVLIPLAERLGVQALKTELEDLVFAILHPEEYARARDAMVRHDSAPDPLAAVAERVRTVLRDAGIAAEVAIRPRHVLSVHRARLKRGGELGGSEYGRLLVLVAEDADCYAVLGELHTCFTPVIAEFKDFIAAPKFNLYQSLHTAIADRDGAITEILVRTRRMHRVAEAGVIALGNPYTTAEGDGGEESPGRTDPTRPGWLSRLLEWQRDASDPDTFWTALRDELAQDREITVFSADGGTIGLPAGATCVDAAYAIDADTGHACIGAQVNGRLVSLGTPLRDGDTLHLLMAAGEASGPSPQWLAHARTPAARIAISRWLAAHPATAEDEPVSHPVRPVPAPDPPAPAEPVALTDRPGAAVRLARCCTPVPPDEVTGFVIRGGTVAVHRKQCPQVTRMTAAGRTLSTVRWRDDPPAAGYLVTVRAEALGRPRLLADLTEAISAAGVGILAADVEPPQQHRVRHTYTIELPRAGALPELMRAMRRVPGVYDVYRTRPEVAATP
>NC_016111.1|WP_014145269.1|4908614_4909502_+|diaminopimelate-epimerase
MHPTHSGLPFLKGHGTENDFVIIPDPDGALELSAAMVARLCDRRAGIGGDGILRVVRSAAHPEAAAMAGEAEWFMDYRNADGSIAEMCGNGVRVFARYLQHAGLVGEGDLAVATRAGVRRPHIAKADADGTPGRITVDMGRATLHPDQVEVTVGDRRWPARHVNMGNPHAVAFVDDLRHAGRLLDAPEVSPASVYPEGVNVEFVTDRGPRHVAMRVHERGSGETRSCGTGACAVAVATARRDGVDPAVTGEPADYTVDLPGGRLLITERPDGTVEMTGPAVIVAEGVVDPAWLGR
>NC_016111.1|WP_014145268.1|4908003_4908552_+|hypothetical-protein
MAMEAGHRDRPQSERPGDELPGLPAAGFPDLPELPEPPGAAGLPELPTVPDALTADGPDSTGHDPEQAAQGSSFRELRPPRRLRVWQLIPIVGLGTVGSLMFAFPLAFEFGDGGPVVAMLGLLLSCCSAGWAIMAARRVGYTWPGLPARGSGDRPDWRFVAGYTAFAVLVALLAVWRVARLR
>NC_016111.1|WP_014628469.1|4906871_4907819_+|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA
MNNAVPYARTPQVIAVVGPTAAGKSDLGTALAERLGGEVVNADSMQLYRGMDIGTAKLTPAERRGVPHHLLDVWEVTRTASVAEYQELARAEIDRLLAAGRVPVLVGGSGLYVRATIDALRFPGTDPAVRARLEAELDEHGSGALHARLAAVDPRAARSILPGNGRRIVRALEVIEITGAPFTANLPAAGPEGAVYDTLQIGVDVPRPVLDERITARVDRMWRDGLLEEVRRLEKSGLRDGLTASRALGYQQVLAHFAGECTEQEARDETVRATKRFARRQDSWFRRDPRVHWLQGDAGELAEQALALLERPVTA
>NC_016111.1|WP_014145265.1|4906458_4906686_-|hypothetical-protein
MGVLEWFRRRSAAGAAVATEAPAQPGPAATPAGDSEPATRPADGRTDAADEAVGIPKQQSAGEAADSETGKGAHT
>NC_016111.1|WP_014145264.1|4906218_4906434_-|antitoxin
MGFLDTIKGKLNRGKAEDLARQHGDQVKGGMDKAGGALDERTGGKYGDQIRGGEEKAKGSYDEWKGGDQGS
>NC_016111.1|WP_014145276.1|4921138_4921942_+|acetyltransferase
MPSTDSNTGLPSIGPAPDDLRADPSGAEPRQPASGEDVRGDAPADTDDTLDLTLPQDVLDLLEEPVTAPGPGDPATDADLLDDLPDWGPVRTPRGVFQLVPVVLSRDLPIVARWMNDPAVAEYWQLAGPERITETHLRAQLDGDGRSRPCLGVLDGTPMSYWEIYRADLDPLARQYPARPHDTGIHLLIGRIADRGDGLGSVLLRAVADHVLDRRPACTRVVAEPDLRNTPSVAAFLAAGFRFAAELRLPDKSAALMIRDRTLRHLL
>NC_016111.1|WP_014145277.1|4922085_4923849_+|IucA/IucC-family-siderophore-biosynthesis-protein
MLHHPPELTAETWSHVSRRLLAKLLAELAYEEVIAPRPETPPADGPADYRLVLDDCAYRFRARRGAYGHWSVEPASITPTGDPFHFLRHARHTLGLTGQTLGHLVRELNATLAADSRLAAHALPVAELAGLDYAALEGHQTGHPWLVVNKGRLGFSAVDADRWTPEARRPGPLPWLAVRTTLAAYRGVPALATAERLYAGELDPAVRHTFDATLRDRGLDPAGYLYLPVHPWQWDETVLPLFAGQIATADVVPLPSDGDLRLPQQSVRTFLNVSHPDRHTVKLPLSILNTLVWRGLPTERTLAAPAVTGWVHALRDADPFLRDECRVILLGEVASVTVHHPFYDRVPEVPYQYKELLGAIWREPLDRHLRPGERARTLAALIHTDPEGRSFTAELVRRSGLDPATWLRRLFAALLPPLLRFLYRYGTVFSPHGENAVVVFDADDVPVRLAIKDFVDDVNVSDEPLPELDAMPDEVRRVLLTEPPDFLPQFIHSGLFIGVFRYLAPLCAEQLGVPESCFWGLVREEILRHQARFPELKDRFALFDLLVPRIDRLCLNRNRLYRDGYRDRPQRPHAAVHGTVANPLHVS
>NC_016111.1|WP_014145278.1|4923925_4925902_+|ATP-dependent-DNA-helicase
MSKPALTDLLHAAVAAVGGVERPGQVAMAEAVAAAVDDGSHLLVQAGTGTGKSLGYLVPALAQGERVVVATATLALQRQLVERDLPRTVAALKPLLRREPQFAMLKGRSNYLCLHRVHEGVPSDEEDGLFDPMEQMGGPTSKLGKDLVRLRDWADETETGDRDALSPGVSDRAWAQVSVSSRECLGATKCAYGAECFAEAARERAKLADVVVTNHALLAIDAIEGAPVLPSHEVLIVDEAHELVSRVTGVATGELTPGAVNRAVKRSARLVDEKAADRLLTAAEGFERVMELALPGRLEEIPEDLAYVLAALRDACRQVITAIGDVRDKSVPDEDAVRKQALASVENVHGVAERLLEGSEYDVIWCERHDRFGASLRVAPLTVSGLLREKLFAERSVVLTSATLKLGGDFNGVAASLGLAPEGVADTEGEGEAPPWQGIDVGSPFEYRKQGILYVAKHLATPGREGSRSDMLDELAELIEAAGGRTLGLFSSMRAAQAAAEAMRGRLDFPVLLQGEETLGELIRTFADDAGTCLFGTLSLWQGVDVPGSNCQLVVMDRIPFPRPDDPLMSARQKAVEEHGGNGFMAVAATHAALLMAQGAGRLIRASGDRGVVAVLDPRLATARYGSFLRASLPDFWYTVDRNQVRRSLAAIAAAADA
>NC_016111.1|WP_041824925.1|4926058_4926829_-|transcriptional-repressor-LexA
MTTTADSATITAQDHAQDRLNPMPTTNEDTPKPGRALPGRPPGIRADSSGLTDRQRRVIEVIRDSVQRRGYPPSMREIGQAVGLSSTSSVAHQLMALERKGFLRRDPHRPRAYEVRGSDAPHSQPTDTTGKPSASYVPLVGRIAAGGPILAEESVEDVFPLPRQLVGDGELFVLKVVGDSMIEAAICDGDWVTVRRQPVAENGDIVAAMIDGEATVKRFKRENGHVWLLPHNAAYQPIPGDEATILGKVVAVLRRV
>NC_016111.1|WP_014145281.1|4927467_4928103_+|transcriptional-repressor-NrdR
MHCPFCRHPDSRVVDSRTTDDGTSIRRRRQCPDCGRRFTTVETASLMVIKRSGVTEPFSRDKVIAGVRKACQGRPVTEDALAQLGQRVEEAVRATGSAELSTHDVGLAILGPLRDLDLVAYLRFASVYRAFDSLEDFEAAIAELREAGAGAPTAAGCRCGRPEEGSDDGSERPGHDQPSARPAGPRSGAERSGAPQGGGTKVPAPSGPGAD
>NC_016111.1|WP_014145282.1|4928388_4931310_+|vitamin-B12-dependent-ribonucleotide-reductase
MTETASGPARSSRKGEKGAKADKATKGLRMERIHTTPGIHPYDEVVWERRDVVMTNWRDGSINFEQRGVEFPDFWSVNAVNIVTSKYFRGAVGSPQRENSLKQLIDRVVKTYRKAGEENGYFASPADAEIFEQELTYALLHQVFSFNSPVWFNVGTAQPQQVSACFILSVDDSMESILDWYKEEGMIFKGGSGAGLNLSRIRSSKELLSSGGNASGPVSFMRGADASAGTIKSGGATRRAAKMVVLDVDHPDIEAFVETKVKEEEKIRALRDAGFDMDLGGDDITSVQYQNANNSVRVNDEFMKAYEQGAKFGLRARMTGEVIEEVDAKALFRKMAEAAWACADPGIQYDDTINHWHTSPESGRITASNPCSEYMHLDNSSCNLASLNLMKFLRDDTASDGASGAGGNMSFDAERFAKVVELVITAMDISICFADFPTEKIGETTRAFRQLGIGYANLGALLMATGHAYDSDGGRALAGAITSLMTGTSYRRSAELAAVVGPYEGYARNADAHKRVMRQHADANTAAKRMDDLDTPVWAAATEAWQDVLRLGEQNGFRNAQASVLAPTGTIGLMMDCDTTGVEPDLALVKFKKLVGGGSMQIVNNTVPKALKRLGYQPEQVEAVVAHIAEHGNVIDAPGLKPEHYEVFDCAMGERAISPMGHVRMMAAAQPFLSGAISKTVNMPESATVEEIEEIYYEGWKLGLKALAIYRDNCKVGQPLSAKKKEEAKTEAPAEVEKVVEYRPVRKRLPKGRPGITTSFTVGGAEGYMTANSYPDDGLGEVFLKMSKQGSTLAGMMDAFSIAVSVGLQYGVPLETYVSKFTNMRFEPAGLTDDPDVRMAQSIVDYIFRRLALDFLPFETRSALGIHSAEERQRHLDTGSYEPAEDELDVEGLAQSAPRQAGPAKAATTAPAAKAQEPAAAPSPKQAHNSTELLEIQQGLNADAPLCFSCGTKMRRAGSCYVCEGCGSTSGCS
>NC_016111.1|WP_014145284.1|4931548_4932793_+|3-phosphoshikimate-1-carboxyvinyltransferase
MTVVEIPGSKSVTARALFLAAAARGTTVLRGPLVSDDSEGFAEGLITLGYQVERGPDAWTITGRPEGPAVNEADVYCRDGATTARFLPALAAAGHGLFRFDASAQMRRRPLGPLTRALRDLGVDLTHQEEEGHHPLTVRAAGIKGGQVTLDAGLSSQFLTALLLLAPLTEEGLRITVTDLVSVPYVEITLVMMRRFGVETVREGDTFVVPPGGYRATDYPVEPDASTASYFLAAAALTGRRVTVPGLGAGSLQGDLRFAEVLRSMGAEVTLTRDSVTVTGADGGRLRGLTVNMRDISDTVPTLAAIAPFADGPVRIEDVYNTRIKECDRLDACAENLRALGVPVATGRDWIEIRPARPAAARIACRGDHRIAMSFSVTGLRTPGITLDDPGCVKKTFPGFHEALAALRTAWETE
>NC_016111.1|WP_014145285.1|4932959_4933736_+|MBL-fold-metallo-hydrolase
MAELTIEYVGGPTAVIEAAGLRLLTDPTFDGPGEHPVGSRSLTKTAGPALAPDAVGPVDAVLLSHDQHPDNLDTSGRAFLARAPLVLSTEAARDRLGDPVRALPAGEWAELPRPDGGTLRITGVPAQHGPDGSESLVGQVTGFLLTGQGVPTVYVSGDNASLDVVRSIADTHGPVDVAVLFAGAARTPLVPDAYLTLTSEQAAEAARILGARQVVPLHFEHWGHFTQGRQTLLDAFATAGDGVRGTLRLLEPGERLTL
>NC_016111.1|WP_014145286.1|4933725_4935144_-|MFS-transporter
MHRDSAPPAPVRTPAGEPPDHHPVLTLLVACTGFFVITLDVNAVTVALPHIGRELGVGVTALQWVLDAYTLLFAALMLSAGTVSDRFGATRVYAVGLAGFTVMSAACALAPDAAFLIGARAAQGAAAALMLPASLSLIRRTRTDPAERARGFALWTAASGVAVAAGPVAGGVLTQALGWRSIFFLNVPVGVAALAALSRTPRIRPRPAPLDGAGQSAVVLALAALVFAVIEGGATGFGSPEVAVASAVAVAAGTAFLAVEARVRHPAVPPALFRERAVAVCTAAGLTMNLGFYGAVFVLSMFFQTQRHLSALVGGVMFLPMTGLIAVVNVVSGRVIARYGPRLPLAAGQLLAGAASLALPAVGPGTPVPLLSAALLPLGVGAGLAAPALTTTMLEAVPAERSGLASGVLNAARQTGGAVGVALFGAFIGGGRFLPGMRLSLLTGGVALLCTGTAVAVLLRGDGGRRRPAVTG
>NC_016111.1|WP_014145287.1|4935296_4935701_-|glyoxalase/bleomycin-resistance/extradiol-dioxygenase-family-protein
MDALHPRLLVRDFDTSLRFWTAALRALHGIEPVKVVPEARYANWDLDGQAVLVIFARENIVRIVGTDSLPEHAAAQDTGMLVLRVADTDDAAARLAAHGATVVAAPQDRPEWGPGLRTAHLRDPEGNLIELQSY

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_016111_2	2.1|1576888|45|NC_016111|CRISPRCasFinder	1576888-1576932	45	NC_016111.1	301159-301203	2	0.956
NC_016111_2	2.1|1576888|45|NC_016111|CRISPRCasFinder	1576888-1576932	45	NC_016111.1	317167-317211	2	0.956
NC_016111_2	2.1|1576888|45|NC_016111|CRISPRCasFinder	1576888-1576932	45	NC_016111.1	4057990-4058034	2	0.956

1. spacer 2.1|1576888|45|NC_016111|CRISPRCasFinder matches to position: 301159-301203, mismatch: 2, identity: 0.956

gctcgcgctggcggtcagccattacctccccggggttcgcccggt	CRISPR spacer
gctcgcgctggcggccagccattacctccccggggtgcgcccggt	Protospacer
**************.********************* ********

2. spacer 2.1|1576888|45|NC_016111|CRISPRCasFinder matches to position: 317167-317211, mismatch: 2, identity: 0.956

gctcgcgctggcggtcagccattacctccccggggttcgcccggt	CRISPR spacer
gctcgcgctggcggtcagccattacctccccggggctcccccggt	Protospacer
***********************************.** ******

3. spacer 2.1|1576888|45|NC_016111|CRISPRCasFinder matches to position: 4057990-4058034, mismatch: 2, identity: 0.956

gctcgcgctggcggtcagccattacctccccggggttcgcccggt	CRISPR spacer
gctcgcgctggcggtcagccattacctccccggggtgcccccggt	Protospacer
************************************ * ******

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_016111_6	6.1|3300060|31|NC_016111|CRISPRCasFinder	3300060-3300090	31	NC_022061	Mycobacterium phage KayaCho, complete genome	56955-56985	6	0.806
NC_016111_6	6.1|3300060|31|NC_016111|CRISPRCasFinder	3300060-3300090	31	KJ433975	Mycobacterium phage 40BC, complete genome	56823-56853	7	0.774
NC_016111_6	6.1|3300060|31|NC_016111|CRISPRCasFinder	3300060-3300090	31	KJ433973	Mycobacterium phage 39HC, complete genome	56823-56853	7	0.774
NC_016111_6	6.1|3300060|31|NC_016111|CRISPRCasFinder	3300060-3300090	31	MT639653	Arthrobacter phage Elezi, complete genome	18777-18807	7	0.774
NC_016111_6	6.1|3300060|31|NC_016111|CRISPRCasFinder	3300060-3300090	31	MN703413	Arthrobacter phage Powerpuff, complete genome	18981-19011	7	0.774
NC_016111_6	6.1|3300060|31|NC_016111|CRISPRCasFinder	3300060-3300090	31	MT024869	Arthrobacter phage Lego, complete genome	18930-18960	7	0.774
NC_016111_6	6.1|3300060|31|NC_016111|CRISPRCasFinder	3300060-3300090	31	MT889366	Arthrobacter phage London, complete genome	18777-18807	7	0.774
NC_016111_6	6.1|3300060|31|NC_016111|CRISPRCasFinder	3300060-3300090	31	MT024871	Arthrobacter phage YesChef, complete genome	18981-19011	7	0.774
NC_016111_6	6.1|3300060|31|NC_016111|CRISPRCasFinder	3300060-3300090	31	MH019216	Streptomyces phage Wentworth, complete genome	44498-44528	7	0.774
NC_016111_1	1.6|643765|32|NC_016111|CRT	643765-643796	32	NZ_CP044329	Methylocystis rosea strain BRCS1 plasmid unnamed1, complete sequence	135038-135069	8	0.75
NC_016111_1	1.5|643764|33|NC_016111|CRISPRCasFinder	643764-643796	33	NZ_CP035514	Haematobacter massiliensis strain OT1 plasmid pOT1-4, complete sequence	154928-154960	9	0.727
NC_016111_1	1.6|643765|32|NC_016111|CRT	643765-643796	32	NZ_CP035514	Haematobacter massiliensis strain OT1 plasmid pOT1-4, complete sequence	154928-154959	9	0.719
NC_016111_1	1.6|643765|32|NC_016111|CRT	643765-643796	32	NZ_CP029827	Burkholderia sp. JP2-270 plasmid p1, complete sequence	4871-4902	9	0.719
NC_016111_1	1.2|643704|32|NC_016111|PILER-CR,CRT	643704-643735	32	NZ_CP020952	Rhizobium sp. CIAT894 plasmid pRheCIAT894e, complete sequence	341657-341688	10	0.688
NC_016111_1	1.5|643764|33|NC_016111|CRISPRCasFinder	643764-643796	33	NZ_CP029827	Burkholderia sp. JP2-270 plasmid p1, complete sequence	4871-4903	10	0.697
NC_016111_1	1.6|643765|32|NC_016111|CRT	643765-643796	32	NZ_CP011667	Streptomyces sp. Mg1 plasmid pSMg1-3, complete sequence	66831-66862	10	0.688
NC_016111_1	1.6|643765|32|NC_016111|CRT	643765-643796	32	NC_014120	Paraburkholderia sp. CCGE1002 plasmid pBC201, complete sequence	368379-368410	10	0.688
NC_016111_1	1.5|643764|33|NC_016111|CRISPRCasFinder	643764-643796	33	NZ_CP011667	Streptomyces sp. Mg1 plasmid pSMg1-3, complete sequence	66830-66862	11	0.667

1. spacer 6.1|3300060|31|NC_016111|CRISPRCasFinder matches to NC_022061 (Mycobacterium phage KayaCho, complete genome) position: , mismatch: 6, identity: 0.806

gcgtcctcgccctcgggggccacggaggcgt	CRISPR spacer
gcgccctcggcctcgggggccacggtgcggc	Protospacer
***.***** *************** *  *.

2. spacer 6.1|3300060|31|NC_016111|CRISPRCasFinder matches to KJ433975 (Mycobacterium phage 40BC, complete genome) position: , mismatch: 7, identity: 0.774

gcgtcctcgccctcgggggccacggaggcgt	CRISPR spacer
gcgccctcggcctcgggggccacgacgcggc	Protospacer
***.***** **************. *  *.

3. spacer 6.1|3300060|31|NC_016111|CRISPRCasFinder matches to KJ433973 (Mycobacterium phage 39HC, complete genome) position: , mismatch: 7, identity: 0.774

gcgtcctcgccctcgggggccacggaggcgt	CRISPR spacer
gcgccctcggcctcgggggccacgacgcggc	Protospacer
***.***** **************. *  *.

4. spacer 6.1|3300060|31|NC_016111|CRISPRCasFinder matches to MT639653 (Arthrobacter phage Elezi, complete genome) position: , mismatch: 7, identity: 0.774

gcgtcctcgccctcgggggccacggaggcgt	CRISPR spacer
agggcttcgccctcggcggccacggcggcgg	Protospacer
. * *.********** ******** **** 

5. spacer 6.1|3300060|31|NC_016111|CRISPRCasFinder matches to MN703413 (Arthrobacter phage Powerpuff, complete genome) position: , mismatch: 7, identity: 0.774

gcgtcctcgccctcgggggccacggaggcgt	CRISPR spacer
agggcttcgccctcggaggccacggcggcgg	Protospacer
. * *.**********.******** **** 

6. spacer 6.1|3300060|31|NC_016111|CRISPRCasFinder matches to MT024869 (Arthrobacter phage Lego, complete genome) position: , mismatch: 7, identity: 0.774

gcgtcctcgccctcgggggccacggaggcgt	CRISPR spacer
agggcttcgccctcggaggccacggcggcgg	Protospacer
. * *.**********.******** **** 

7. spacer 6.1|3300060|31|NC_016111|CRISPRCasFinder matches to MT889366 (Arthrobacter phage London, complete genome) position: , mismatch: 7, identity: 0.774

gcgtcctcgccctcgggggccacggaggcgt	CRISPR spacer
agggcttcgccctcggcggccacggcggcgg	Protospacer
. * *.********** ******** **** 

8. spacer 6.1|3300060|31|NC_016111|CRISPRCasFinder matches to MT024871 (Arthrobacter phage YesChef, complete genome) position: , mismatch: 7, identity: 0.774

gcgtcctcgccctcgggggccacggaggcgt	CRISPR spacer
agggcttcgccctcggaggccacggcggcgg	Protospacer
. * *.**********.******** **** 

9. spacer 6.1|3300060|31|NC_016111|CRISPRCasFinder matches to MH019216 (Streptomyces phage Wentworth, complete genome) position: , mismatch: 7, identity: 0.774

gcgtcctcgccctcgggggccacggaggcgt	CRISPR spacer
tcgtcctcgccctcggcggcgacgatctcgt	Protospacer
 *************** *** ***.   ***

10. spacer 1.6|643765|32|NC_016111|CRT matches to NZ_CP044329 (Methylocystis rosea strain BRCS1 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.75

atcgc-cacccggccccgcacgcacgagcgcgt	CRISPR spacer
-tgacgtgcccgctcccgcacgcacgagcgcat	Protospacer
 * .* ..**** .*****************.*

11. spacer 1.5|643764|33|NC_016111|CRISPRCasFinder matches to NZ_CP035514 (Haematobacter massiliensis strain OT1 plasmid pOT1-4, complete sequence) position: , mismatch: 9, identity: 0.727

catcgccacccggccccgcacgcacgagcgcgt	CRISPR spacer
cgcgcgcccccggccccgcacccaccagcgcga	Protospacer
*..   * ************* *** ****** 

12. spacer 1.6|643765|32|NC_016111|CRT matches to NZ_CP035514 (Haematobacter massiliensis strain OT1 plasmid pOT1-4, complete sequence) position: , mismatch: 9, identity: 0.719

atcgccacccggccccgcacgcacgagcgcgt	CRISPR spacer
gcgcgcccccggccccgcacccaccagcgcga	Protospacer
..   * ************* *** ****** 

13. spacer 1.6|643765|32|NC_016111|CRT matches to NZ_CP029827 (Burkholderia sp. JP2-270 plasmid p1, complete sequence) position: , mismatch: 9, identity: 0.719

atcgccacccggccccgcacgcacgagcgcgt	CRISPR spacer
gcgcgtatccggcgccgcacgctcgagcgcgt	Protospacer
..   .*.***** ******** *********

14. spacer 1.2|643704|32|NC_016111|PILER-CR,CRT matches to NZ_CP020952 (Rhizobium sp. CIAT894 plasmid pRheCIAT894e, complete sequence) position: , mismatch: 10, identity: 0.688

aaccgagggcggcgcatgccacccgtgcgatc	CRISPR spacer
ggccgagggcggcgcaagccgcccggccatgt	Protospacer
..************** ***.****  *.  .

15. spacer 1.5|643764|33|NC_016111|CRISPRCasFinder matches to NZ_CP029827 (Burkholderia sp. JP2-270 plasmid p1, complete sequence) position: , mismatch: 10, identity: 0.697

catcgccacccggccccgcacgcacgagcgcgt	CRISPR spacer
tgcgcgtatccggcgccgcacgctcgagcgcgt	Protospacer
...   .*.***** ******** *********

16. spacer 1.6|643765|32|NC_016111|CRT matches to NZ_CP011667 (Streptomyces sp. Mg1 plasmid pSMg1-3, complete sequence) position: , mismatch: 10, identity: 0.688

atcgccacccggccccgcacgcacgagcgcgt	CRISPR spacer
gcgctgacccggacccgcacgcgcgagcgccc	Protospacer
..  . ****** *********.******* .

17. spacer 1.6|643765|32|NC_016111|CRT matches to NC_014120 (Paraburkholderia sp. CCGE1002 plasmid pBC201, complete sequence) position: , mismatch: 10, identity: 0.688

atcgccacccggccccgcacgcacgagcgcgt	CRISPR spacer
tgcgccacccggcgcctcacgcacgctgggtc	Protospacer
  *********** ** ********   *  .

18. spacer 1.5|643764|33|NC_016111|CRISPRCasFinder matches to NZ_CP011667 (Streptomyces sp. Mg1 plasmid pSMg1-3, complete sequence) position: , mismatch: 11, identity: 0.667

catcgccacccggccccgcacgcacgagcgcgt	CRISPR spacer
tgcgctgacccggacccgcacgcgcgagcgccc	Protospacer
...  . ****** *********.******* .

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	670153 : 679007	12	Rhodococcus_phage(33.33%)	terminase	NA
DBSCAN-SWA_2	1773245 : 1791486	26	Mycobacterium_phage(40.0%)	portal	NA
DBSCAN-SWA_3	1798378 : 1804934	8	Gordonia_phage(33.33%)	tail	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>NC_016111|670153:679007|DBSCAN-SWA
GTCAGGTACCGGGCCGGTAGTCGCGCAGCCAGTCCATGGCCTGCGCGGCGCCGTTCTGGCTACCCAGGAGGTACAGCAGCGCCTGGCTGGTGGCGTCCACCTGGTCGTCGTGGGGGGCGTTCGGGAAGGAGGCGGTCTCCTCGACGTACTCCGCGATCCACGGGGCGAGGTCGGGGGCCGGCAGGTGGACGTTCCCAGCTTCCACGAAGGGGGCGACGGCGGAGGCGCGCGCGTACTTGCTGCCTGCCGGGTTCACCGGGATCAGGCCGGGCACGGTGGCGCGCAATTGAGCGACGATGGCGGGCCCGTTGGCTTTGTCTTCGACGAGCTTGGCGTGGCTCTGGGGCCACTTCGCCGAGAGAGCTTCCACGGCGCGACATGCGGCGGGGAAGTCGAGGCGGTCGCGGACCTGGTCCAGCAAGAACACCTGCGCGCCGATCTTCGCCCACACTTGTCCGACTACGAAGTCGGCTTTCGCGGAGTCCTTGAAGGTCATGTCCCACGACTGGATGACCTGGTGGGCCGCGGGTACCCACCAGGTGCCGTCCGGGCGGCGCTCTGCCCGTAGCGCGGTGTACCACTGCCAGTGTGCGCGCTTGAACAGCCCCCCTTCGGCCGGCGCCGGGCGCCCTTGGTACAAGGCATTCCACGTGCGGGCGCCAACGTCCTGCTTGGTGTCCTCCCAGTCCTTGATGGTCCGGCCCCGCGCTGACAGCAGGTACTCACCGGGGGCGCGGCCGAGCGGGTCGTCGTCGCTCTCAGCCTGTGCCGGGATGTTGATGTGCCGCCAGTCACCGCGGGTGTCCTGGGCGAGCAGTCTCCCGGCGAGGTCGTCTTCGTGCCAGCGGGTGAGGACGACGATCACCACCGCCTCGGGGGCAAGGCGTGTGCGAGCGGTATCGGTCCAGAAGTCCCACACCCGCTCGCGGAACACTGCGGACTCGGCCTGGGCGCGGTCCTTGATCGGGTCGTCGATGATCAGTACGTCGACCGGGCGGCTCGTCAGCGCACCGGCCACGCCGACGCTGTACACGCCACCGATGTGGTCCCGGAGCTGCCATTCCTGCGCGCTGGAGGTGTCGCCTCGGATGTACAACCCGAGGGCATCGGGGTGGGACCTGATGTCGTTGCGGATCGCGCGTCCCCAGCGCATCGCGGTGCGCTGCTCGTAGCTCGCGATGGCGACGCGTAGGTCCGGGTTCCGCGACAACATCCACGCCGGAAAGGCCCGGGAGACACGCTGTGACTTGCCTTCCTGGGGAGGCATCGTCCAGATCAGCCGCCGGCAGCGACCGGCGGCGACGTCCATCAAGTTGGCGTCCAGGAGTTCAAGGGCGGGCGTGGCCACGATCCGTGGGTCGAGGGCCTTGGCCAGGTGGTGGGGGGCGGGGTATCGGTCGGCGGCTGCATTGCGGCCTTCGAGCCGGTCGGCCGCGCGCACGAGCGCGTTCAGGTCGGACATGTGCAGGTGCCTCTGGCCGAGGGTGCAGGGGCTTGTGAGAGGGGGTGAGCGCGGGACCGAGGGTCACGGGGCGGTGGGTAGGGCGATATGGAGGCTGTCGAGGACCATCACGGCGTCCGGGACGCTGATGTAGGCGAACTCCCAGTCGGTGCGGCCGTCTCGGTCAACGGTGGCGGTCCACTCGGCGGTGGTGGCCTCGTCGTACCAGTAGTACTCGCCGGGGCCGGACTGAGCGATCCCTCGGGGCGCGTCTTCGAACAGGCCCGGCAGCAGCCTGTCCAAGACGACGCCGGCGACGTGTGGGAGGCCGGTGAACTCAATGGTGGCGCGGGTGTGATCGTCTACGCACACGGTCCCGGATCCGACGCCTGCCCGTTCCCAGCGCAGGCGTGTGGGGCAGCAACCGGTCGGCGGCGGCACGTCCACGAGCAAGGGGAAGGCGGTGCGAAGCGCGGTAGCAGCACTCTGGTGCTGGCGGGTGAACGCCTCTCGCCAAATGGCGAGTGCTCGTGCGGCGTCGGGCTGCACAACACCTCCCTCCCACTCGGAGCACCCGTCTTCACGCCACAGAACGCAGGTGCCGGGCAGCGGCTTGGCGAGCCGCCACGGCGGCGGCTCCGGTGATCCCCGCAGCCGCGAGGCCGGCTTCGAGCGCCGACACCAGCGCTTCGGCCTGGCGCTCGGTGACGCGTGCCATACGGTCTTCGATGTTCAGCCGGGCGATCATGCCGAGGATCTGTCCGGCCCGGTCCATGGCCCGCTCGTACAGGGCGATCTCGGCCCGGAGTTGCTCGGTGCCTGCCGCTCCCTCGTACCGGATGCGGTCGCCGAGGCGCTGCACCATGCCGCTGATGGCTTCCTGCCAGGCGACGGCCTGGCCGGCGAGCCGGGCCAGCGCTGCGAAGGGGTCAGCGACTGCCTCGACATTCAGGTCGGCGAGAACGGCGCGGGCCTCGGCTTCGGCCTGCTCGGTGCGTGCTGCGGCGCGCTGGTTGCGGGTGTTCCCACCGTGGAGGCGACACCGGCCGAACCCCACGTGATCGGTACCCCAGCCCGCCACCAGGCTGCAGACGTCACCGGGAGCGCCCTGCCGCTTCTGGGCGCCGCACTGGGGTGTGCCGTCCGCGGCCTGTTCCGGCTTCAGGCTCACTCGTCACTCCGGCGGTGCAGGCGTTTGATGCGCTGCCGGCGGTCGGCGATAGTCAGTACCCGGTCGACCGCAGCCAGGTCTCCCTTCATCGCCGGGCCCCACAGGGCCGCTTGCAGTCGGTCATACCGCAGGGCTTCCAGCATGCGCTCCGGGTCGAGCGGCGGCCCGTCGTACTGCTCGTCAGCGATCTCCCCTGCGGCGAGCACGGCGTCGGCCACATCCGGGTACCCAAGCTTGGTGGCGATGGTCTGCCAGTCCACTCCGGCCAGCTTCAGCGCGAGGGCTTGACTGGCGCGTTCACGGTCGCGGGCATCCATCGGCGGGCTCCCTATCGGGTCAGGAGGGTATGGAGGTCAGCACGCGCCTGCGGGTCGGTCAGGAATCGACCGGTGTAGGAGGCGGTGACCATGGACGCCCCCGGCTTGCGGGCGCCGCGGTGCGCCAGGCAGCCGTGTTCGGAGCGGATGATGCAGGCCGCGCCAAGGGTGTCCAGATGCTCGTCCAATGCGGCGGTGACCTGCCGGGTCAGCTGTTCTTGGGTCTGCAAGCGGCGGGCGTACACGTCCAGTACCCGCGGCAGCTTGGACAGGCCGGCGACCGACGCGCCGGGCTTGGGCTGGTACGCGATGTCCGCAGTGCCGCTGAACGGGAGCAGGTGGTGTTCGCACAGCGAGGTGAACGGCACGCCGGTGACGGCGATGGGCTGCCCGGCATGGTCGGCCGGGAAGGTCCGCGACAGGTGGAATGCCGGGTCGTCGCGGTACCCGGCGGTGAATTCGCCGAGCGCTCGCAGCACTCGCGTGGGGGTCTCGGCCAGAGCCGGGCTGTCGGGGTCCAGGCCGATCGAGGCGAACCATGCGGTCAGGCCGGCGGTGAACCGGCGGGCGGCGACGCGGAGGGAGGGGTCGGGGTTGGTCATCGTGCCCTTTCGTTGCCCCAGGTGAGGACGTGGAGCCGGGTGGTCAGGTTGTAGCCCGCGCGAATGGCGGGGTCGGCGATGACGGCCAGGTGGCGGCCGATGGTGGCGGCGTCGGTACCGCGCGGCATGATCCACACCTGCTCCGGGGGAATGCCCAGCGCCTGCACCCACTTCTCGGTCTCGGTGACGTCCTCGGCCGAGGCGCAGACGTACTTGAAGGTGGCTTGGCCGGTGTCGCGTAGCGCGTGGATGGCGTCTTCGCGGATGCGTCTGCTCTCGCGGTCACCGGCGCTGGCGAGTTTCGGCGAGACGTTGAACCGCGTGGCCCATGCGGTGGTGAGCGGCGTCGGCGCGATCGTGCCGTTGGTCTCGATCTCGATGTCCACCCCGGCGTCGGCGAGACGGTCCAAAAGATCCAGCCAGCCCGGCTGGTGCTGGTGCAGCAGTGGTTCGCCGCCGGTGATGACGACCACAGCGGGAGCGCCTTCCAAGGCGCGGGCGGCGATGTCGGCGGTGGGCTGGCGGGTGAGCTGGGTGCGCAGGTCGTAGCGCGTCGCGTCCCACGTGTAGGGAGTGTCACACCAGGAGCAGGTCAGGTTGCACCCGCCGAGCCGTATGAAGGCGGCGCGCCGGCCGGTGGAGGGACCTTCCCCCTGCACGGTCGGCCCGAAGACCTCCGCGACGACGAGGGTCGGGCCGCTCATGATGCAATCCAGGTAGCGGCGTTGACGTGGGTCTCGGCCAGGTGGACGCGGGTGACGCGGGCGCCGGGCGCTCGGACCAGGTCCCGGAGTACGCCGGCGGCCATGTCGGCGAGCAGGGCGGCGACGTTCTCCACGGTCGGCCATCCGGTCACCTCGTAAGCCTTGCAGTCGAAGGAACGCAGAACGGGCAACAGCGGGTCGTTAGGACCGAGCATGACCCCGTGGTCGAGGTGGGTGTCGATCCACTGGCGCAAGGCCCGCTTGAATGGCCCGAACTCGACGACGAGGCCGGCGGCGAGCTTGGGCGCTTCGACGGTGACTTCGGTCCACCAGGAGTGGCCGTGCAGGGAGGTGCACTTGCCCGGCAAGTGGGGCAGTCGGTGGGCCGTCTCGAAGTTGTGGCGGACGGTCACGCTGTGGGTCATTCCAGGCGTCCTCTCATGATGATGCGGGCCAGGATGACGCTCTGGTCTCCCGAGCCTCGGGTATCGGCGAGGGGGTAGGCCGCTTGCGGCCTCACGATCCGGGCAAGGGCGGAGTACCTGTTCGGCGCCGGAACCGCGGCGTGTTCGTGGTCGGCGCACCCGAGGGCGCGGCCTGGGGCGACTTACGTCGACTACAGGCGATGACCACCAGGTCAGGGGAGGTCACACCGCATAGTCGGTGGGGTCGGGTACGCCAGCGTCAGCGAAGGCTTCGCGGCGTTCGGTGCACGTACCGCACGTGCCGCAGTGCTGCTTTTGGCCCTTGTAGCAGCTCCACGACAGGCCCAGTGGGGCACCGAGTAGATGTGCGTGCTCGGCGATCTGCGCCTTGGTCCACGTGATGAACGGCGCCTCGATGCGGGGGGTGTGGTGGCCCTCAAGTGCCCGGGTGACGCAGGCCCTCAGGGCGTCGAGGAACGCCGGGCGGCAGTCGGGGTAGATAGCGTGGTCACCGGCGTGGATACCGAGGCCGACGAGCTGTGCTCGGCGAGCGGCGGCGATCCCGACCGCGATGTTCGCCATGATCGCGTTGCGGTTGGGCACGACGGTGACGCGCATGGATTCGGCCTCGTAATGCCCGTCCGGTACCTCGATCGCTGGATCGGTGAGGGCGCTTCCGGGCATCAGTGCGCCGACGGCCGTCAAGTCCACGACCTGGTGTTCCGCGTCGAAGTGCTGGGCGACCCGCCGAGCGGCGAGAAGTTCGCGGCTGTGCCGCTGGCCGTAGTCGAAGCTCAGCAGCATCATCTCGTAGCCGCTGTCGTGGTAGTGCGCGGCGAGAGTGGTGGAGTCCATGCCGCCGGAGAAGGAGAGCACGGCGAGGGGGCGACTCATGAGGTGTTGTCCTTCCGGGCGTCAGCGGCCAGCGCGCGGGCGGCCACGGTGAAGTTCTTGGTATCGGTGTCGGCGAGGAACAGGCCGGTGCCGGTGCTGGTCCACCCCGGCGGCGGGGCCACGTGGTGACGGCGTTCGAGCCAGCGGCCAAGGCGCCCGTAAGCCACTGCGGGGGTGGCGCGGATCATGGTGTCCTCGGCCTGGAACTGCTCCGGCGGCTTGCCTGCCTTGGTAGCGAAGCCCCGTCGGCCGACGACTGCGGGGTCTGCGCCGTGGGTGCGCAGGAGCCCGGCGTGCTTGCGGGCTTCGGCTGGCCGGCCCACGGTCAGCTGCACGATGCGGGAGTGCTGGCTGTCCCACAGCGACATCACTCCGAAGCGTGCGCCGGACGCCCAGCTGGAGGAGTCCACTGTGTAGAACGGCAGCGCGGCGATGGTGGCGAACCGGGTCTGGCCGAAGCCGTGGTAGACCGCGCCGTGGTGGCGTGCGATGCGGAAGGCTCGGATCAGCCAGCGCATCACGTCGTCGGTGCGTCGGGCGTAGGGCACCATTCCGCCCAGCGCGATGTACCGGTAGGAGGCGCACAGTGCTTCGAGGCGCCGCCAGGGGGATCCGATGTGGAATACCGGCAGGACCCGGATGCCCTGGTCTTCGAGGGCGAGGGTGTTGCGGTGGGTGGCGTCGGGGTCGCCGATCACGTCAAGGGTCGCGGCGGTGGTGATCACGTGGCGCCACTGGTGCAGCCAGGCCGCGTAGTCGGCCAGCTTGATGGTCGAGCCAGTCGTCGCGGCGGAGAATGCCCCGGAGTCAGCGAAGACCTCGTAGGGGCCGCCGTAGGCGGCGCCTATCGCGGCGAGGTCGGTCTCGCGGTGGTAGTGGAAGCTGGTCAGGTAGCGGAACACGGGGCTCCTGGTGCGAGGGTCCGGGCGGCGAGGCGCATCTGCTCGTCGTCGGTGCAGGCGAGGAACAGGCAGGTGCCGGTATCCGACCAGCCAGCCGGTGGAGGAACACGGTGGCGTCGCGCGAGCCATGTCTCCAGGCGGTGGAACGCGGTCATCGGGGCGGCGCGCATCATGTCGTACTCGCGAGCGTGCTCAGCCGCAGTGCGATGAGCGGTGTGGGCGAACCCTGGTCGGCCGACGACTGCGGGGTCTGCACCGTGGGTGCGCAGGAGCGCGGCGTGCTTGCGGGCTTCGGTTGGTCGGCCGACCGGCACGGTGACCAGGCGGCAGCGCCGATCGTCCCACAGCGTGATGTTGCCGTACCGGGCGCCGGATACCCACGCGGAAGAGTCCACGGAGTAGAACGGCAACGCGGCGATGGTGGCGAACCGGGTCTGGCCGAAGCCGTGGTAAACCGCGCCGTGGTGGCGTGCGATGCGGAAGGCTCGGATCAGCCACCGCATCACGTCGTCGGGGCGCTTGGAGTGCGGGACCATGCCGCCGAGGGCGAGGTAGGCGTGGCGGCTGCACAGGTCCTCCAGCATCGGCCAGGGGGTGCCGACGTGGAAGGCGGGCAGGACGTTCAGTCCGGCATTCAGCAGCGTGGCGGTGTTGCGGTGGGTGGCCTCGGGGTCGCCGATCACGTCCAGGGTCGCGGCCGTGGTGATCACGTGGCGCCACTGGTGCAGCCAGGCCGCGTAGTCGGCCAACTTGATCGTCGAGCCAGTCGTCGCGACGGAGAACGCCCCGGAGTCAGCGAAGATTTCCACCCGGCCGCCGTGAAGGGCTTGGAGATCACCGACGAGTTCCCCCATATCGGTGTCGCGCCAGTACGCGTACGACGTCAGGCAGCGCAGCGTCATCTCACCGCACCCCCTCCTCCAGCAACATCCGCAGTGGTGCGATGTCCTGGTCCCGCGCTCCGGAAAGAGCGAGGTACACCTTGGTGCCCTGGTCGGCGGCGCGGGGCAGCGGCGGCGCAGGTACACGGTGGCGGGTGGTCAGGGACCCCTCCATGAACTGGTAGGCGCGGGCACAACCGGCTGTGAGCAGATCCCGGTCGGCTCCGGTGGATCCGGCGGCGGGCCGCATGAAGTTGCGGTCCAGCAGCCGGTGTGGCGGCAGGCCGTGTGCGCGGACCAGCGCAGCGTTCGGCAGTACGTCGGCGGGGTTGCGGAAGAACAGGCTGCGCATACGGAGAGTGCGGGCGTCCCACAGGTAGACCAGACCGAAGCGTTGTCCCATCGTGTAGGAGCTGCTGTCGATCGAGTAGAACGGCAGGTGGCGGACGAGATTGGCGGAGGTCAGCCCGAAGCCGTGGAGCGCGGTGCCGTAGGGCCGAGCGACTTTGAAGGCGCGGATCAGCCAGGCCATGAGCGCCTTCTGCTTGGCGGCGCCTGCGGCGTGGAGCGCCAGCCCGCCGAGGGCGATGTACCGGTGCTGGGCGCACAGCCCTTCCAGCACGTCCCAAGGCTCACCTGTGTGAAACACCGGCAACACGCTGCAGCCAGCCTCGGTGAGGCGATCCAGGTTCGCGGCGGTGGCCCGGTGGTCACCGATCACGTCAAGGGTCGCGGCGACGGTAATCAACGGCTGCCAGTGTCGTAGCCAGGCAGCGTAGTCGCCCAACTTTATCGTCACGCCGGTCGTCGCAGCGGAGAACGCCCCGGAGTCGGCGAACAGGTCCACGTTCCCGCCGAGATCGTGCACCAGGGCGGCCAGGTCGGTATCGCGGTGGTAGTGGTAGCTGGCCAGGACCCGCAGCGTCACGCCATCGACCGCAGCTTGTTCATGAGGTGGATGAACCGTGCCGCGTCGTCGTCCGGTGTCTCGCACCCGGACGACAGGTCGTAGAAATCGTCGCGTACGTTGGGCGGGACCTTGAACCGCAGTACGGGCCACAGGTCGTCGTCCTCAGGCTCGCCGAACTCGGCGGCGAGTGCGTCCAGGTCCGGCGGTGGTGTGATCAGCATCTCGACGTCGGTCTCGGTGTAGCCGGTGCCGGTGTAGTCCCCGTCGAGGTAACTCAGCAGCTCCGCCAAGGCGTCGTTGTCGTATGTGCCCAGCTCCGCCAAGCGGTTGTCCGCCAGGTTGATGCGCCGGGCCTCGGCGTCATCGCACCTGACAATCTCGCACCGCGCGGTCTGCGCGCCTTCGGCGGCGAGAGCCTGCAAGGTGTGGTTTCCCGCGAGGACGATCAGCGGTCCGCTTGGTATCTCCCGGACGATCAGCGACCGGTACTGTCCGTTCCGGCGCAGGCTCTGGCGGATCGCCTCGACGTCCCCCCTCTTGGCGTTGCCGGGGAACAGCATGAGTTCGTCCAGGGGAACGTCGCGGGTGGTGACGTACTCGGCAGGCAT

Protein sequences of DBSCAN-SWA_1

>NC_016111|670153:679007|670153_671614_-|WP_014141342.1|terminase|DBSCAN-SWA
MSDLNALVRAADRLEGRNAAADRYPAPHHLAKALDPRIVATPALELLDANLMDVAAGRCRRLIWTMPPQEGKSQRVSRAFPAWMLSRNPDLRVAIASYEQRTAMRWGRAIRNDIRSHPDALGLYIRGDTSSAQEWQLRDHIGGVYSVGVAGALTSRPVDVLIIDDPIKDRAQAESAVFRERVWDFWTDTARTRLAPEAVVIVVLTRWHEDDLAGRLLAQDTRGDWRHINIPAQAESDDDPLGRAPGEYLLSARGRTIKDWEDTKQDVGARTWNALYQGRPAPAEGGLFKRAHWQWYTALRAERRPDGTWWVPAAHQVIQSWDMTFKDSAKADFVVGQVWAKIGAQVFLLDQVRDRLDFPAACRAVEALSAKWPQSHAKLVEDKANGPAIVAQLRATVPGLIPVNPAGSKYARASAVAPFVEAGNVHLPAPDLAPWIAEYVEETASFPNAPHDDQVDATSQALLYLLGSQNGAAQAMDWLRDYRPGT
>NC_016111|670153:679007|677511_678417_-|WP_014141352.1|DBSCAN-SWA
MTLRVLASYHYHRDTDLAALVHDLGGNVDLFADSGAFSAATTGVTIKLGDYAAWLRHWQPLITVAATLDVIGDHRATAANLDRLTEAGCSVLPVFHTGEPWDVLEGLCAQHRYIALGGLALHAAGAAKQKALMAWLIRAFKVARPYGTALHGFGLTSANLVRHLPFYSIDSSSYTMGQRFGLVYLWDARTLRMRSLFFRNPADVLPNAALVRAHGLPPHRLLDRNFMRPAAGSTGADRDLLTAGCARAYQFMEGSLTTRHRVPAPPLPRAADQGTKVYLALSGARDQDIAPLRMLLEEGVR
>NC_016111|670153:679007|675702_676608_-|WP_014627371.1|DBSCAN-SWA
MFRYLTSFHYHRETDLAAIGAAYGGPYEVFADSGAFSAATTGSTIKLADYAAWLHQWRHVITTAATLDVIGDPDATHRNTLALEDQGIRVLPVFHIGSPWRRLEALCASYRYIALGGMVPYARRTDDVMRWLIRAFRIARHHGAVYHGFGQTRFATIAALPFYTVDSSSWASGARFGVMSLWDSQHSRIVQLTVGRPAEARKHAGLLRTHGADPAVVGRRGFATKAGKPPEQFQAEDTMIRATPAVAYGRLGRWLERRHHVAPPPGWTSTGTGLFLADTDTKNFTVAARALAADARKDNTS
>NC_016111|670153:679007|672760_673081_-|WP_014141345.1|DBSCAN-SWA
MDARDRERASQALALKLAGVDWQTIATKLGYPDVADAVLAAGEIADEQYDGPPLDPERMLEALRYDRLQAALWGPAMKGDLAAVDRVLTIADRRQRIKRLHRRSDE
>NC_016111|670153:679007|672173_672764_-|WP_014141344.1|DBSCAN-SWA
MSLKPEQAADGTPQCGAQKRQGAPGDVCSLVAGWGTDHVGFGRCRLHGGNTRNQRAAARTEQAEAEARAVLADLNVEAVADPFAALARLAGQAVAWQEAISGMVQRLGDRIRYEGAAGTEQLRAEIALYERAMDRAGQILGMIARLNIEDRMARVTERQAEALVSALEAGLAAAGITGAAAVAARQAAARHLRSVA
>NC_016111|670153:679007|673679_674387_-|WP_014141347.1|DBSCAN-SWA
MSGPTLVVAEVFGPTVQGEGPSTGRRAAFIRLGGCNLTCSWCDTPYTWDATRYDLRTQLTRQPTADIAARALEGAPAVVVITGGEPLLHQHQPGWLDLLDRLADAGVDIEIETNGTIAPTPLTTAWATRFNVSPKLASAGDRESRRIREDAIHALRDTGQATFKYVCASAEDVTETEKWVQALGIPPEQVWIMPRGTDAATIGRHLAVIADPAIRAGYNLTTRLHVLTWGNERAR
>NC_016111|670153:679007|678413_679007_-|WP_014141353.1|DBSCAN-SWA
MPAEYVTTRDVPLDELMLFPGNAKRGDVEAIRQSLRRNGQYRSLIVREIPSGPLIVLAGNHTLQALAAEGAQTARCEIVRCDDAEARRINLADNRLAELGTYDNDALAELLSYLDGDYTGTGYTETDVEMLITPPPDLDALAAEFGEPEDDDLWPVLRFKVPPNVRDDFYDLSSGCETPDDDAARFIHLMNKLRSMA
>NC_016111|670153:679007|673092_673683_-|WP_014141346.1|DBSCAN-SWA
MTNPDPSLRVAARRFTAGLTAWFASIGLDPDSPALAETPTRVLRALGEFTAGYRDDPAFHLSRTFPADHAGQPIAVTGVPFTSLCEHHLLPFSGTADIAYQPKPGASVAGLSKLPRVLDVYARRLQTQEQLTRQVTAALDEHLDTLGAACIIRSEHGCLAHRGARKPGASMVTASYTGRFLTDPQARADLHTLLTR
>NC_016111|670153:679007|676592_677510_-|WP_014141351.1|DBSCAN-SWA
MTLRCLTSYAYWRDTDMGELVGDLQALHGGRVEIFADSGAFSVATTGSTIKLADYAAWLHQWRHVITTAATLDVIGDPEATHRNTATLLNAGLNVLPAFHVGTPWPMLEDLCSRHAYLALGGMVPHSKRPDDVMRWLIRAFRIARHHGAVYHGFGQTRFATIAALPFYSVDSSAWVSGARYGNITLWDDRRCRLVTVPVGRPTEARKHAALLRTHGADPAVVGRPGFAHTAHRTAAEHAREYDMMRAAPMTAFHRLETWLARRHRVPPPAGWSDTGTCLFLACTDDEQMRLAARTLAPGAPCSAT
>NC_016111|670153:679007|671677_671965_-|WP_041824366.1|DBSCAN-SWA
MCVDDHTRATIEFTGLPHVAGVVLDRLLPGLFEDAPRGIAQSGPGEYYWYDEATTAEWTATVDRDGRTDWEFAYISVPDAVMVLDSLHIALPTAP
>NC_016111|670153:679007|675034_675706_-|WP_014141349.1|DBSCAN-SWA
MSRPLAVLSFSGGMDSTTLAAHYHDSGYEMMLLSFDYGQRHSRELLAARRVAQHFDAEHQVVDLTAVGALMPGSALTDPAIEVPDGHYEAESMRVTVVPNRNAIMANIAVGIAAARRAQLVGLGIHAGDHAIYPDCRPAFLDALRACVTRALEGHHTPRIEAPFITWTKAQIAEHAHLLGAPLGLSWSCYKGQKQHCGTCGTCTERREAFADAGVPDPTDYAV
>NC_016111|670153:679007|674383_674812_-|WP_014141348.1|DBSCAN-SWA
MTHSVTVRHNFETAHRLPHLPGKCTSLHGHSWWTEVTVEAPKLAAGLVVEFGPFKRALRQWIDTHLDHGVMLGPNDPLLPVLRSFDCKAYEVTGWPTVENVAALLADMAAGVLRDLVRAPGARVTRVHLAETHVNAATWIAS

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014141342.1|670153_671614_-|terminase	phage terminase large subunit	A0A249XNL6	Brevibacterium_phage	1.2e-145	55.8
WP_041824366.1|671677_671965_-	hypothetical protein	NA	NA	NA	NA
WP_014141344.1|672173_672764_-	hypothetical protein	NA	NA	NA	NA
WP_014141345.1|672760_673081_-	hypothetical protein	NA	NA	NA	NA
WP_014141346.1|673092_673683_-	GTP cyclohydrolase I	A0A2H4GYC9	Pseudomonas_phage	4.6e-27	41.6
WP_014141347.1|673679_674387_-	7-carboxy-7-deazaguanine synthase QueE	A0A2P1JXY9	Rhodococcus_phage	1.2e-50	45.6
WP_014141348.1|674383_674812_-	6-carboxytetrahydropterin synthase	A0A2P1JXS3	Rhodococcus_phage	1.3e-15	36.2
WP_014141349.1|675034_675706_-	7-cyano-7-deazaguanine synthase QueC	A0A2P1JXV3	Rhodococcus_phage	1.2e-44	45.8
WP_014627371.1|675702_676608_-	hypothetical protein	A0A142F2D2	Mycobacterium_phage	2.7e-34	37.0
WP_014141351.1|676592_677510_-	hypothetical protein	A0A142F2D2	Mycobacterium_phage	3.4e-37	36.2
WP_014141352.1|677511_678417_-	hypothetical protein	A0A142F2D2	Mycobacterium_phage	1.7e-33	40.7
WP_014141353.1|678413_679007_-	ParB N-terminal domain-containing protein	A0A222Z9L3	Arthrobacter_phage	1.7e-18	35.9

Sequences of DBSCAN-SWA_2

Nucleotide sequences of DBSCAN-SWA_2

>NC_016111|1773245:1791486|DBSCAN-SWA
ATCAGTGCTTGGATTCCTCCAGTTCCAGGACCGATCCCCAGGACCGGTCTCCGATCTCGCCCTCAGCCGGGATCAGCACGCCCCGGATGGTGAACTCCATGAGCCGTGCGGCTTCCCTGGTCAGCTCGGCAGCGGCATCGCGTGGGAAGCTGAACAGGATCTCGTCGTGGATCGGCAGCCGCATGTACGGCGCGAACCCGGCGTCCGCCAGGCGCAGCAGCGCGCGGGCCGTGATGTCCCGGCTCCCCGACTGGATGAAGTAGTTCAGGGCTGCGTACGCGCGTCCCCGGTCCACCGGCAGGCGCCTGCCGGTGGGGGTGTAGACGAACCCTGTCCGCCTGGCCTCGTCGGCGAGCTGCTTCGCCAGGACCCCGACGCGCGGGTATGTGTCGGCGAACGCGCTGAGCGTGCGCTTGGCGGTCTCCTCGTCCACGCCGAACTGTTCGACCATGGCACGCCAGCCGCCGCCGAACACGGTCAGGAAGTTCGCGCCCTTGCCTACCTTTCTCGGGACGCCGGCCGCGTCCGCGGTGATCTGGTGCAGGTCCAGGCCGTTGGCGAACGCGTGGAGCATCGTCGGGTCTTGGGAGAACGCGGCGAGGTCGCGCAACTCCATGTTTCCGAAGTCGATCGACACACTTACGTGTCCTTCCTCGGCGAGGAACATGTGCCGCACGTAGCCGTCCCCGGCCGGGAATGTCTGGGCGGGCACGCTGCCGGTGATGCTCATGCGTGCTGTGCGTGCCTGGATGGAGTTGATCGACGCGTGGACGCGCCCCCGGCTGTCTCTGCCGTCGAGCGCTCGCTGGAACCAGGTTGCCGACCACTTGCGGGCCCGTCGCGCCTTGATGACTGCTTCGGCAAGGGGGTGGTCGATGCCGTTGAGTACGTCATCGTCCATTGCCAGATTGCCCTTGGCTGTCTTCTTGGTGAGACGGATCCCGAAGCCCAGGAATGCGTCTACGAGCTGAGCGGTGGAGTTGATGTTCTCGACGCCATACCTATTGGCTACCTGCTCCCATCGCTCGTACTCGGCGGCCAGCTCCGCTAGGCGTGCTTCCGCATAGTCGGAGTCGAGCAGGTAGCCTGTGCGCTCGATAAGTCCGGTGACGTGGTTGAGGCGGTGTTCCCAGGAGAACAGGCCGCGCCTTTTGGTGCGTGCCGGCACGAGTGGCCAGAGGATGTGGAACAGGCGGTAGGCGAGGATGGGGTCCATTCCCGCGTAGAGCAGGAAGTCCTCATCGAAGAGTTCAACAATGGGCCATATCTTGTGCTTCGTGGTCTTGTATTTCCGGGCCAGGAGAACCATGCTCCCCTTGACCTCTTCGGCGACTACGGGATCGATGTAGTGTTTCGTCAGCTCTTCGAGTTTGAGGCCCGGCCCTTTCTCCTTGACTCCTCTGGGGTCTACGAGGTGTGCGGTGATCTTCGTGCAGATCGTCTTGGGCGCCAGAACCTCCAGGGGGATGCCCAGGGACGCCTCAATGACGTGCTGGTCGAAGATGGCGTTGTGTGCGATCAGCGTTCCGGCGCCGAGCAGTGCGCGTTGCGCAGCCCTGCGGTAGGGCTCCCCCAGCTCGACGGGGATCACGTAGGACTCGCTGCCGTTGCCGAACTGGGCCAGGCGCAGCCGGAATCCGCGGTCCCAGTCCCACCAGTTCAGGCCGGTGGTCTCGGTGTCGAACCCGAGCACCGGATTCTTGCCCAGCCAGCGGTCGAACTCCCGGATATCGTCTGTCGTCTCGACTACGTTGATCCGCACTTGCTGATGTTTGATCTTGTAGTGGAGATGCTTCAACTTACTCCCGGAATGCGCGGACTATGCAGTAGACGACGACCGCAACGGCGATAGTCAGGCACATGGCGGTGACCCCCGTTTCGATTGCTTTGAGCTAGCTGCCTTCGTAGGCCGATATGAGTACGAGGATCAGGAGCATGGCGAGCATGCCGTAACAGAAGGCGTAGATCACGGTGCGGACTCCTTGCAGTGGTGAGCTGTGGTCGCAGTGGCAATGTCCTGGGCAGTTACCGCATTGTTGTCGCAGCATGCGCAGCCTCCAGAGGCAATCTGGGTTTCGCATTTGGCGCACCACAGATCGACGCCGCCGTTTTCCAGTCCGTAGACGAGAATCCGGTTTGCTTCGGTCATCGGAATTCCTTCAGGCACCGGGCCGGCACGTGCGCGGCCGGTGAGTATTTCCATGCTTTGCACGGGCCTGCCATGTTCAGCCAGACGCCGAGTGCGAGCGCCAGCAAGAGTGCAATCACTGTCGTCAGGGTTTTCATGTGCCTCCAAAAGGGCGGGGCGCCGGTGGTGGCCGGCGCCCCGCGATCTGCTGTGGTCGATTACTTGGCCTTGAAGCCGCCGTCCTTCTGGCGCCACAGCGGTTCGCACTTGCCGCCCTCGGGGCCGTTGCAGAACATCGCGGCCCAATTCGCCTTCTCGACAAGGCTGCGGCCGTGGGGGCAGTCGTCGCCCGCAACGGCGGGAGGGGTCTTCGGGACCACCTTGCCGTTCTGGAAGGTCTTCGGCCCCGTGCCGCCAGCGCCTCCCTTGAACTGGCTGCGGGTGTAGTCGGCTGCCTTGGCGGTGAGGTCGATCAGCCCCTCTGCCTTGAGGGCGTTGAGCAGCGCGGCGCCCGCACGTGCGGTGTCCTCGGCGGTGTCGCCGTACACGGTGGGGGTCAGCCACTCGGCGTCATAGCCGCTGCCGGCCTTGAGCGTGAAGCCGATCTTGAATCGGGCAAGGTGGCGCGAGGTTTCAGGCATAGGCGCGGTCTCCTTCTTCGCGGTGGTGGTCTGGTGTGAGGGCACGTCCCACGGGGACTTGTCCTCGAAGGGGTCGGGGTAGCTCAAGATCACTCCACGGGTTGGCAATTCATTCGTTCGTCGGCGGGGTGTCAGATCGGGCAGGCGCCCGAGGTGCAGTCCTCGTCGTAGCTGGTGTCCACCGCGCGGTGGTCCAGGTCGGCCGTCAGCCGCTCGTACTCCTCGGCCGTGATGCGCTCGTACGGCGCCTGCGCCCGGCTGGACTCCGGGAAGACCGTGCTGCCCTTCAGTCGCGGCATGTAGTGCAGCAGCACACCGGCCAGGTCCTCGACGGTGTACTGGTCAGGGTCGATCACGGCCGTGTAGCTCACGGCCTGGTCCGCCCAGCACTGCTGGTACATCTCCTGCACGCTCAGCATGGCGTCCAGGTCGAGCTGGCCGGCGTGCTCGTATGCCTGCTCCAGCACCTCGTCCAGCAGCACGTCCCGCGTCGGGATCGCCACCACTGCCGTGTTGGCTGCGTAGATGCACGGCTCGACGTGGTAGCCGCTGCGCCGGTACTCCTCGACCTGCGCGGCCTCCGCCGGGTCCAGCAGCGAGAACCGGATGCGGCGGACGAAGTAGCCCGCGTACGGTGCATGGATCCCCTCCCCGGAGACGCCGGCCAGCTTGCTGATGGTCCCGGTCGGGGCCACCACGCGCCGCTTCACCGGCACGGGGATACGGAGCTGGGCGGCGTACTCCTGGGCAGCCCGGTCCACCACCGCGGCGTACGTCTGGAGGTCGTACGCCACCAGGCCGTGGTCGTGGTGCGCAGCCTGCGAGTACGGGATGCCCTGCTTGGCCAGGTAATCGGCGAGCCCGGTGTGCCCGACGCCGATACGGCGGTTCCGCGCGATCACCTCGGCCGAACGCCGGTCCGCGACCGGTGCGAACGTAGCCCGGACCAGGTAGCGGGTCAGCAGCCGGTGTGCCTCGTCCAGCTCTTCCCAGTCAGGGCGCCCGTCCTCGACGAACGCGGCGAGGTTGAGCGAGCCCAGGTTGCACGGCTCCCACTGGTTGAGCGTGGCCTCCCCGCACGGGTTGACCGTGTACGTCCCGTCCGGCTCGCCCACGGCCGACAGCGACGAGTTCCAGAACCCCGGCTCCCCGTCGCGCAGCGCGCCCTCGGCGATGGTGGTGAGCACCTTTCGCGCAGCGGGGTCTCCAGCCTCGGCCATGGTGATGAACTCGGAGTCCACCTCCACGGAGATGTTGGTGGTCCAGTGCTCGCTCTGCTCCCGCTTGCACCGGACGAACTCCTCAATCTGCGAGTCCCGCCAGTGCATGACCGACATACGCGCCGAGCGGCGCACACCCCCGGCCACGATGCACCGCGCGATCTCGTGATCGATCTCCATCGCATCCATGCCGGTAAGCGGGAACCCGGCGCAGTCGGCCAGGATCTCTCCGGTCCGGATCAGCAGCTCCGCGAACGGCGCCGGCCCGCTGGCCGTGCCGCCGAACGACCGCAGCGCAGCGCCCTTCCGGCGGAGCCGGCTCACGTCGTAGACACGATCGGTATGCCGCACCTGCGGGTTGTGGGCCGTGCGGATCAGGTCTGCGAGGGCGGCGGCCCAGCCCTCCCGCGAGTCCTCGACGGCATAGGCAACGTGCCAGGTGTAGGCATAGTCCCCGGACAGCAGCCCGGCTTCCGCCATCTCCGTGTAGTCAGGGTGCGCCGGGTCGCAGACGATGTGCACCTGGAGCGCGTTCTCCACGGCCGGGAACTCGGCAAAGTACCGGTTGCTGTAGTTCGCGCCGACGCCTCCTCCCTCGGCGAGCCGGAGCAGGGTGAACGTGAAGTGCTCTTCCGGCCGCGCCGGATCCCAGCCCGCGGCCCAGCAGTTGTTGAGGGCGTAGTCGGTGACGCCGCTGCCGCGCAGGTGGCGGCCGGCGGGCAGGACCTTGAACGTCTCGATCAGCTCGACCAGGCGCTCACGCTCGTCCGGCTCGATGAACTGTTCGTCCACGAGCGCAAGGTTGCCGTCGACCACGCGCTCGACGGTCTGAGGCCAGGTCTCCAGTTCCCCCGACGGCAGCTCCCGGCTGTAGGTGCGTTCGTAGACGGTTCGGGCGGTCTCGGTCCTCCAGGCCGTCACGCGGCTCCCCTCTTGGTTCGGATGTGGCGGTTCATGGACAGGGCCAGGGCGTCAACGGCCCGGTAACCTCGGCGCCGTTCGGCGTCATTCACCGGGGGCATTCCGTAGACGTAAAGCCGCTGGATCAATTCCTGATATTCGTTGCTCAGCTTCGGCAGCGCTGCGGCAGCGTCCAGCCGCGCGGGCATGATGTTGTCGGAGATCACGCACCGAGTCAGGTCGTCCTTCTTACCGACAACGTCTCCAATTTCGTCGTCCGTATAGACGAACGTACGCAGAACGGTCCGGACTTCATCGGGTGTGTAGTAATACTGATCGTCCATCAGGTCTCGGTAAGCGCGCTCCTTGGCCGCGTACCGGCGCCCGGCATTCCAAAAGACCTTGCGAATGAACTCGTGGTCCTCGGCATGCTCGGCGAGAGTGCGGCGCTCCTCCATCGCGTGCAGCAGGATTTCCTGCTTGACGTCATCGACTTCAACCACGCACCACTTGTTAGCGATCTCCCGGGCCACCTTGCCGGCCAGCTCGCTAAGCTGTCCCCAGTCGAGGTCCGTCATGCGACCGCCTTCATGGCGCTTTCCCAGGCCAGCTCAGTAGACCCGTCCGGGTAACGGACGATGTAAGTGAAGTCGCCATCCCTATCAGGTTCACTGGCAACACCAACGATCTTCCCTTCGCAGCAGTACACCTCGACCTTCTGCTCGATCTGGTACTTCGGAGACAGAACACGCTCGAAAACTCCGCCTACGCCGAACAGGGCACACTTCGCTATCTGAGGGGATGCCCACTCGTCACCGATGTAAGCGACGTATTCCGTGCCTCCGTGCTCGAACGGCTCAGCCACGGTGAAAAAGCTTAGCCCGCTCATTTTCGAACGGTACTCCCGCCCCTTCCACATACTCATGCCTTACCCCCCTTAGAAATGAACTTTCCGCGCGGTCCGCGCTTGATCTCGCCATACCGCTGGCCCTCGACCACGAACGATCCGTCGTCCTCGATCGGGATCGCGTGCGGAGTGGCGTTGTACTTGCCGACGTAGAACAGGCCGAAGCCCTTTTGCCAGTTGGCCGGCCCGTTCTTGAGATATCCGGCCTGGCGGACATCCATGAGATGTCCGACCTCGAACCCGTAGATGGTCCGGAGCTTTCCGTTATGCCCGGTGGTGTGCGGAGCGATGGCCAGCCGGTGAGTGTGCCCCATGACGATGCTGATTCCGGCCTTGGCCGCCTTGAGCCGCGCAGTCGCGCCAGCCACCTGGCTCATTCCCGGCGACTCGTGCCCGTGGACCGCCACCCATCCAGGCGCCAAGGGGTAATAGGGTTCGGCCTTCTTCACGTCGAAGGCCGGAAAGTCCAGCAGGGTCTCAAACCGGTAGAACGTGTCCTCGGCCGCCAGCGCCGGCGCCCGGCTGGCCAGATACTTCCGCGGCCGTTCGTCGTGGTTGCCTTCCAGCACCTACACGGGGCCGGAGTAGACCTCACGAAGCGGAGCCAAGAAGTTCCTCTTGGTGTACTCGGAGTCCCGGATCACATTCCCCTCGAACTCCGCCCGGGTACCTGCGGACCACCGCGACGGAGCCGGGTAGTCCACCAGGTCGCCGATCTGGATCACTTCGTCCGGCTGGTAGTCACCGATGAACGCGAGGACGTTCCGCAGCGCCCGCTTGTCTTCGAATGGCGCTTGCACGTCGGATATGACAACTATTCGCTTCACATGGCTCCTCGGGAGTAGGTCGGCTCCGGTAGGTCGATCTCGACGTACCGGCCCAACCAGCCATCGTTGACAGTGTTCAGGTCCATAGCGTGGATGGGCGAACAGTCGCCGTTATCCAACTCGTAGCCATCGGCGTAAGCGGCTTTGATCGCCGCTTCAATAGCCCTTGCGTGTTCTTCGAGAGTCAATCTGCTACCTTCAGACTCTCGATCTCGTAGTCGAGATACCAACGGGCCTTCTTCAGGTCCTCCAGCTCGTCACCCTTTCGCCCCGCCCGCATCAGGTACTTCAACGCGTTCCCACGGACGAACGAGAAGTGCCGAGTTATCTCGATGACTTCCATGCCTCCGGGCATCCAGGTGTAGTGGCCCGGGTGGTCGATGCCCTCCTCCTCCGTGGATGGTTCAGTGCTCGCGGGCATCAGCTCGTCCTCCGCGAACATGTAGCGGCGCCCGTCAGGGAACATCACCTCGTAGGGGAGGAAGTATCTGGAGTCAATGTCCGCGACCGTGCCGGTCTGGCCCTTCCGCTCCCGCAGCACGAAGGAATATTCCCTGCCCTTCGGGGGGCAAATGGTCACCTCGTCGTCCAGCCCGAACTTCAGCTTCACAGGCCGATCCTCTCTCTCAGCACGTCGAACCCGTACTCGTACGCGAACGAATTGGAGTCATGCCGGGGGGCCGGGATGATCACCTTTGCGTTGGGCATTTCGGCAGCGCGCTTCTCCGCAGCCGCAATGCCGGGCTCGTCTCCGTCGGCCACGTGGTAGACGTGCCGGAACCCCATGAAGGCGGGATCGAAGTGGGCGCGCCACGCTGAGGTGCCCTGGTAACCGACGGCCGGGACACCAGCCGCCTCCCATGTCATCGCGTCCATTTCGCCCTCGGTCACGACCACATTCGGGCTGGAGCCGATCAAGGCCATGGTGTTGTACAGCCGCGGCACATCCCCCGGGAGCGACCGGTACTTCCCGTGACCCTGGTGCCGCTCCTTCTGAAGCGGTGCGAGATACCGGCCTGCCTCGTCTTTCACGCACTCGTCGGCGATACAGCGGCACCGCACCGTGGCCACACCGTGTTCACCACCGGCCGGCCGCAAGTACGGGATGACGAGCATCCCTGCGTACTGCTCATGGCCAGTAAGAGCCGAACCGACGAATCCGATTCGAAACCGGTCGGCGACGCCGGCCAGCCCCCGAGCCTTCATGTACGCCTCGGCCGGACTCCCCTTGTACTGCCAGTGGTACGTCTTCGCTGCCTGTACCGAACCGGCTATCTGCAAACTCCTGAGCCTGTCTGAAGCCAAATCCCTCCTCCCTCTGGATCACGTCATAGCTGTCCTCGGACACGTCACAGACGAAACATGCCCATCGTTGAAAGCCGGTGTTTGCTGACGCGCTCGGATTCGTCTCCGGGTGAAGCGGGCACAGAATCTTCTGCCACCCGCTCCGGTCCCGAAGTTGGATGCCGTAGTAATGCTTCAGCACCAGGGCGATAGGCGGCTTACTGCTCACGCGCCGGCACCGGGTCCCCGACCTTCCGAACCGTGACGGGAAAGACATAGCGCTTCGAATTCCGCGCGTTCCAGTCCCGGCTTCCCTTCCACGCCCGGTAATCGAAGGCAACCGACTTGCGCTCACTCATCTTCAACCAGCCTTCCTCAACTGGCGCTCCTGGCGTAGGAGTCGCTTCAGATCCCAGTTCTCACGGACTAGAGACAGCAAGCTGTCAAAAGGCATCACCGAGTACGCCTCGCCGGTTCCCTTGAGCCTCGCTTTGATGACGACGGCGCCATTGGTGGCCTGCGGATTGTGCTCCAACTCGCGCTTCAACTCCCGCATGAAGCGGGCCAGGTCGAATCGCTGGACATTCTTCATCTCGAACACGAAGGCCAGAGGCGCCAGCGTGATGTCCCCGCGGTCGTTGACCCCGTACAGGGTCCCGTGGCGCCGGATCTCCTCCGGGTCGATCTCAGGAAACGCGGCCCGGATGTGGTCGAGGGCCTGCTTCTCCCACCGGTAGCCCTTGTCCTTGTTGGCCTTGGCGGTGGTCACCATCGCCCCTCCCCACTCTCAACGTAGAGGAACAGGATCCCCTGATTCAACTTCACGGACAAAAAAAATTGTGACTCAGAACTCACTCTCCAAGTCGGTGAGTCGCATGTTGGCGCTGTTGAACTCGTACGTTGTGAACGTCTGCCCCGAGCTGTCCTCGAACCCTTCGCGGTTCTTTACTGGACTCACGTGCAGCAGCCGCCCATCCATGCCATCGATCTCCTTGTGGATCGTCAGGATCACTGAAGGGACCCGGCCGATCTTTCCCTTCACCCCAGACAGCGGGATAGGCCGCAGGCCGTCACTGAACTCGCCCACGACATGGTGGAGCCCAAGAACGTGGGCCTGCGTGTCTCGGGCCATCTCTGACAGGTACTCACACATTGCCTCCAAGCCGAACGAGAAGTTCCCAGCATCCGCTTGGCCGTCTCCCCCATCCACATTGGTGATATTGTCCACCACGATGAGATACGGATATATACCGAAGACCTCGTAATAGCAAGCCAAGTCCTGCTCAATGTCACCCGGCGTCGGCCTTGCCTCGTAATTGAACCGTATCCACCAGCGCTCGCCCAGCGCCGCATGGTACTCCCCGAACTCGTCGGCGATCAGCTTGCGCTTCACCTCTCGTACGTTGTCCCCCGTCAGGATGGCAGTCGCGCGGGTGAGTTGCGTTGCCGCGTTGCTGTCCGCACTGAAGTACAGAACCGGGAGATTTCCGAACAACGCCAGGTTGATGGCGAACAAACTCTTGCCAGTGCCAGGGCCAGCAGCCACCAAGCTCAGCTCCCCGCGTCGAAACTCGACCTCCTGCCGGCGCAACCCGGCGAACGGGTTGGGGATCGGCTCCCCGGCCGAACCTTTGACCTCGACGCTCTGCGTTAGCGAGTACACGCACTCTCCCTCTCGATCCCCTGATTCAACTTGTAGCATAAAAAAAACAGCCGTGCGACACGTCGCAGAACCGGCACCCGTAGCCGGGGTTCGCCTCGAACCTCCCTGCCTTGACCCCGGCGTCCATGGTCGCGTAGCGCTCCCCAACCTCGGCAGGGCTCACCTGATCCAGGGCGACGGGACGGGACAAGCGACCATCCTTAGCCAAGTACCAGTCACCGCGTCGGACCGGCACGTCGTACAGGGACTCGATCGCCACGGCGTACGTCTCCAGTTGGAAGCGGCTCTTGATGCTCCCCGTCTTCAGGTCCCGCACCCGCACGGCGTCTCCGTCGGCCTCCATCACGAGCAGGTCAATGATCCCGCGGACGACGACTCCCCCCAGCTCGACCGTGAACCCCAGCTCCACCGCCGGCTTTCCGGCCGGTGTCGTCCACACCTCGGGGCGGTGCTCAGCCACCCAGTCAACGTACTGGGCCGTCTGCTCCTGGCCCAGGACGTAGCGGCGTTCGATCTCTTCGCCTCCGCTGTACCGGCCGGACGACAACCACCGATCGGTGTCCGGCTCGATGTCCAACGCATCCTGCACCAACCGGGCGTACTTGTCGGAGAAGGCTTCGACGGCTTCCTCAGCGGTCATCCTGCCGTTGGACAGCACCACGGCTTCCGCCACAGCGTGGAACGCGCTGCCGTGGAAGCTCCACGCCGCCGGCCGAGGCGTCACGCGCTCGACCCTGGCGAGGTAGTACCGCCAACCGCACTCCTCGTACTGCTGCACCTGGCTCACACTCCGGGGCTGTGTCTCTACGCTCAACGGGCTCAACCCATCACCACCTTGCTCACGCGAATGAATTCAAAAAACCGGCTGCCGAGGATGGCAGCGTGCGGGTACTGGAACGCGCCCCGCTCGACCTCCAGGTCGAACAGGGAGGCCCCCAACTCCGCCTCCAGGCGCCGCAGTCGGGCGTACCCGGCAGCCTGAATTTGGTCGGTCACGATCACGTCGATGTACTCACCAACCGGCTTGGCCAGCGTCCTCATGATCAGGACGCCGAACGTGCTCGCGTCCTGCTGCACGCTTACCAGCTTGCTCTGGTCGATGGCTGCCAGGGCGGCTTCCTGGCGCTCCCTCGACGGCGGCCTTTGCGAGGCTTCTTCCAGCGCGGAGAACAGACTCAGCTGTCTGGTTTCCTCGGCCGTGTCCGAAGCCCCCGTAACGACGATCACTTGTGCACTCCTCGTCGCCCGGCGCAGCGGTGCCGCGTCGGGCTGATCACTCAGTGCTCACAAAGTAACACCAGCCTCTGACAACACAGAAGTTCGTTTATGCCCCGCGCGAAAGTGACGTGCGCCACATCACCAACAGCTTGCACGGCGCGAAACCGACAGGTATGCCCACTTCAACTGCTACCCCGGGGAACAGAAGAGCCCCCCGGGTCCGGGAGGCTCGCGGTGTGAGTATTGACAAATTGACACGCTTGCTGTATTAGCTCCAGGGTTTGGAAGGTAGATCGAGGGCCTGCGCCAGGTCCCCCGGTGGCAACTCCTTGCCTTCCGGCCAGCGAATGACGCGCCGCCCATCAGCTTCGACGCGATGCACGAAGACCCACGGCCCCTCGGGATGCGCCCGGTCGAAGTCGAGCACCACGCCCTCCTCCCGGACCTTCCGCTCAAACAGCTCTGCCACATACCGCTGATTCACACTGAGCGTGGGATCGCCAAGCCTCCGGCGGAGGAAGACGTGCAGGCTTCGCGCCCGGCTTCGATCCGTGAACTGAACACGTCCCGTCTCCCCATTGGGCCACGCAGCCTCAAAAATCGCTGTGGCCGCATTCGCATAGGGATAGCGCTTAATCCCGAGATTATCCAAGCGCTTGGCGACAGCCTGCACAGTCACCCCGTACAGCTCGGCTATTTGTCGGTTCGACAGGCCATCGCGGTAATGCTTCAGAAGAATCGTGTCGTCTGGAAGCAGCCTCTTCATAGCTTTAACCGATCTGTCAACTCATTACCCGACCACTAGCCTGTCTGCGCCTCGACGGTACCTCTATCGAGGGCCACGGTTCAAGTCACACTGTCCCCTGAGTCAACTAGGTGTGACGTGCGTCTCAACCCCCTGCTTCAACATCCGAAGCGCCTCGGTTTGACACCGACATCATCAGTGAGAGAGCGAGAGAAGCGAGCGAACGAACCGAGGGGAACGCTCTCAACAGAGAGCATAGAACATAGATTCGAATCTTGACTCTCTCTTGACGCCTACTTCATCAGTTCATGATCATCTACATATCTAGTCGAAGTAGGACAGATAACTTATGACATCTTGTTGAAATTTTCACTTAGTCATTACAAGTCCTCCTGCTGAACGCCCTGTTGAGGCTCTTCGCCTCCGGGCAGGTCCAGGAGTCAGCGCCCCGGCTGCCAGACCAGCATCCAGCCGGGGCCACAGTCATGGCCTGCCGTCCCCGGGTAGCTACCAGGGCCGACGGGTCCAGGGATGCGGTGTGTGGAGTGCACAGGGAGCCAGTAGCCGGCCGGTAGCTCCGGCCCGCGAGCCCCTCCCAGGCGCCGGTTCGACCCCGGCCATCCCGGTCAACTTCCGAGGAGGGTGAAGCCGTGCCAAGGGCGCGATCAATCTGCCTGACAAGCGGCTGCACGACCCCCACCGTGCGCGACGGACGATGCGCCGAACACCAGCTCCGCCGGAGCTGGGAACGGACCTCTGCGCGCAACCTCTCACGGCCTGCGGACTGGTCGAAGCGGAAGGCAAAAATCCTCGTCCGCGACCGCTTCCGCTGTCAGTTCTGCGGCTCTCCCCGGAAACTCGAAGTGGATCACATAATTCCGGTTTCCCGAGGTGGCTCGTGGGAGCCAGACAACCTGTGGACATTGTGTCAGTCGTGCCATAAACGCAAGTCACACCACGACCGACAGAGCCGCTGAATCAGCACAGAATCACACCAAACTTGCGTTGGGCGCTGGGACGCACGGGGGCCTCTAAATCCCTCGCTCTGTACGGAGCTGGTCCGGTTCGATTCCGGGGCAACGCACTCACTCAGCCAGACACATGACGCTGGCATATGCATGCGGGTCGCTCCCGCAGGTCCAGGGGCCGTGAGGCGCGCTACCGGTCTCCCTGGGCGGTGTCCGTAGTTCAGCGGCCGAGAACTCCTCCCTTCAGGAGGTAACGCCGGTTCGAATCCGGCCGGACACACCGCCACACCTAGTTGTGGATTCATTCATTCACCCTTCCCCTGGAGGCCCACCCATGACTGCCGACCGCTGTTCCCGCCGATGCGACGAGGGGCCCTAGGCCGACTCCGGCTCGGTGCCGGCTCCCCGCCCGCCCCGGGCGCAGCAGCGGCGTGACTGGCACCAGGACGCGTTGTTCGAGCTGGAGGAGCTGGCCGACCTGTACGGGATCGACCTGGAGCGGGTGAGGCTGTGACCAGAGGACCCCGCCCGAAGCCCAACGCGGTCCGGCGCAACGCCCATCCCCACGCGCAGGAACTCGCCGCGGAGGCTCGTGAGGGCCGGCCCCTGCCGAAGGCGCTCGGGATCCAGACCAGCGGCGCACGCCGGTTCTGGCGGACGTGGGCCCGTGCACCGCAGACGGCCACATGGGTTGAGACCGACTGGGCTGAGCTGGAGATCACGGCGAAGCTGGTTGATGCCCTGTACATGGGCGATCTGAAGTTGGCGCCCGAGATCCGGCAGCGGGTAGCGAAGTGGGGCGCAACGGTTGAGGACCGTGCACGGCTCCGGATGTCCCTCAAGGATGAGGACCAGGACCAGGATGACGCTGGGCCGGAGTCCGCGGCGCCGGCCGCCTCCGACATGGACGAGGAGCTGTACCGGTTGCTCAACGGACCCTAACCGCCCATGAGATTGACGACGGGAGGAACCCCGACATGCAGACAGGCAACCTGCCCGATGGGGTTCCGTCCCCGCGGGAGTCCCTGGGTTACCAGGTGATCCGCTGGGCACAGCGGTAGATCGTCCACCCCGACGGCGAGCGCGCGGGCGAGCCCTGGCAGTTCACCCCCGAACAACTCAAGTTCGTGCTGTGGTTCTACGCCATCAATCCCGATGGCACCTGGCGCTACAGCGCTGGCACCCTGCGACGGGCGAAGGGCTGGGGCAAGACCCCGTTGCTCGCCGCCTTGGCCATTGTCGAGTTCATCGGCCCCTGCCGCTTCGACCGCTTCGACGCCTTCGGCCTGCCGGTCGCCAAGCGCGTTCCGCTGCCCACGGTGCAGATCGGTGCCACCGCGCTCGACCAAACGGACCAGACACTTGAGATGATCCGAGGGATGCTCTCGGAGTCTCCGGCCGAGAAAGAGTACGGGCTGGAGATCGGCAAGTCCGTGATCCAGTTCAAGTCTGGCAAGCCGGGGTCGATCCGGCCGAAGGCGACCGCTGGCCGCACCAATGAGGGCAACAGGCCGACGTTCGCCCTGCTTGATGAAGTACACCACTGGGTTGGGAGCAACGGCGGCCCCGACTTCTACCAGGTCATCAAGCGCAACGTAGAAAAGACGGCCTCCGCTGGCTCTCGCTGGGTGACCACGACCAACGCCTAGAACCCGAATGAAGATTCGGTCGCTCAGCAGATCCACGAGTCCGACATGGTTCGCCAGGGCTTCTGGCTGTACGACTGCCTTGAAGGCAACATCCAGCCGGACGAGCTGCGCGACGAAGCCAAGGTCCGCCAGGCGCTCACCGAGGCGTACGGTGACGCGACGTGGGCCGACATCGACGGCCTGACGCGCACCATCCTGCACGACCGCACGACGCCTGATTCGACGTACCTGCGCTTCTTCTTCAACGCCATCGCGGAGTCTTCCGACGGCTGGATGGTCCGCGCGGAGTGGCTGGCCTGTTACGACGACCAGGACCCCATCAAGCCGGGCGATCAAATAGCCGTGGGCTTCGATGGCTCGATCCGCGGAGACGCCACAGGGCTCGTGGGATGCAGGCTCCGGGACGGAAAACTCTTCGTCTTGGGGATCTGGGAAAACCCTCGGGACCCCAATAACCCTGACTGGGAAGTTGACGTCCTGGCGGTCGAGGCCGCAGTGCACCGAGCCTTCAAAACGTATCGCGTCCAGTGGTTCTACGGTGACCCGCCGTACTGGCAGGAGAACCTAGGCCGCTGGGCTCTCGAATACGGTGACGACTACGTATACGAATTCTGGACCAATAAGCCTACGCGCATGGTCCAGGCCGTTGAGAGGTTCCGCACCGCTTCCATGGTCCAAGACCTGAAGCACGACGGAGATGAAGACCTCACCCGGCACATTCTCAATGCGGTGACGCGTGAAGTCCCTCAGGGACTCCTGATCACCAAAGACTCTCCCCGTTCAAAGAAGAAGATCGACCTCGCGGTTTGTGCAGTCCTGGCTTTTGAGGCGCGAGCCGACGCAATCGCGGACGGGCGCCTCACGATCAAACGAAAAAGAGTTGTCGGGTTCTGAGAAGGGCCCCGGAAAGAAAGGGGCTTGATGGACGGCGGTAGCCTCGTCAGCACGACGCCGGCCGAGATGCCGGTAGGTATCGCGCCGAGCACACCTGAGCAGTGGGTTGACTAGCTGTATTCGAAGCTGGCCCGCCGCAAGGCGACCTACCAGATTTAGGGCCAGTATTACGACGGCCAGCATCAGCGCCTCATGTTCTCGCAGGCACGGCACTACAACCACTTCCACCAGACCTTCGAGAGCTGGCGAGACAACTTCTGCGGCTTGATCATCGACTCGGTGAACGAACGCCTCACCGTGGACGGTTTCCGGATGACTGACGAGCCGGATGCCGACAAGGATGCTCGGGACATCTGGCAGCGCAACTACATGGATGCCGAACACAACGCGGCTCAGCTCGACGCGATGATTCAGGGCGCCTCTTACGCGGTTGTGTGGTCGGACGACGACGACCAACCGACCATCACCATGGAGAGCGCTGAGAACGTTGTCGTCCAGTACAAACCAGGGTCCAGGCGTGAACTCGCTGCCGCGGCGAAGTTCTACTAGGACGACTGGGGCCGGGAATGGGTGAACCTCTGGCTTCCTGACGCTGTGTGGTCGTTCGCCAAAGGCTCTTTGGCGTGGGGAGAGGGGCAAGAAGGCCCTAATCCACTGGGGGTTGTTCCAGTGGTTCCGATCAGCAACCGGTCTCGGCTGCTGCGTGACCCGGTGAGTGATCTCCATGTCGTCATCCCGATCCAGGACGCCATCAACAAGACCGTTGCTGACGCTCTGGTGGCGTCGGAGTATGCGGCTTGGCCTCAGCGCTACGTCACCGGCCTGGAAATCGTGGAGGACGAGCACGGCAATCCGGTTGAGCCGTTCAAGGTCGCCGTGGACAAGCTGCTCCAGGCCGAGGACCCGCAAGCCAAGTTCGGTCAGTTCGAGGCCGCCGACCTCGGCAACTACGTGACGCTGGTGGAGATGCTGGTCCAGCACATGGCCAGCATTTCCCGGATCCCGTTCCATTACTTCCTCAATGGTGGCGTCGTCCCGTCCGGTGAGTCGATTACCGCTGCGGAGGCAGGTCTCATAGCCAAGACCCGTGAGCGCATGCTGCACTTCGGGGAGGCATGGGAAGAGGTGATGCGCCTTTGCTTCAAGGTGCTGGACGATCCCCGCTCAAAGGCGTATTCGGCAGAGACGATCTGGAAGGATCCGGAGAACCGCACGGAAGCACAGCACATGGACGCTCTGCTCAAGCTCCAGATGATCGGCGTTCCGAGGGACCAGTTGCTTTCCGATGCCGGGTACACGCCTCAGCAGATTGCGCGGTTCCAGGACATGAGGGAAGCCGATGCCAAGGCCGCAATGGAGTTGGCGAAGAAGTACCCGATGCCTGTCCCGGAACCGCCGGCCGGGCCCGTCGGCATGAGCAAGGCGGCCCAGCAGACAGCCGTGAAGCGCCCGCAGGGCAACAGCGGCAACCAGGCCCGCAAGTCGTGACCACGGCTCCCGAAACGGGAGCCCATACCGAAATGGTGATGTGAATGACTGACACGAACGACAACACTTCTTCTTCTTCCGCCGAGCAGTCCGCCCCCGGCGAGCAGGCTCCGACGATCGAGACTCTTCAGGCCGAGGTCGAGAAGTGGAAGAGCTTGAGCCGGAAGAACGAGGACAGGTTCAAGGCGACCAGCGCCGAGCTGGACCAGGTGCGCCAGGCGTCCATGACGGACGCGGAGAAGGCTATCGAGGCGGCGCGGGCGGAGGCGCGCAATGCGACTCTCGCCGAGGTCGGAACTCGGCTCGCCGAGGCTGAGCTACGGGCCCATGCCGCGACTGCCGGTGTCGAACTTCCTCCCGCCGAGTTCCTGAACCTTTCCCGGCTCGTCGGCTCTGACGGTTCCGTGGACAGCGACGCACTGACAAAGCTCATCGCGTCCCTCCCCAAGCGGAGCAACAAGCCCGTATACCGGCAGGATCTTGGGTTGGGGCGGCAGGGTGACCCGACCGCCGGCCAGCTCACCCGTGAAGAGGTTTCCCGCATGACCGGTCCGCAGATCATGGCTGCCCGCAAGGAGGGCAAGCTTGACGCTCTGATGACCGGCCAGTTCTAATACGTGAGGTAACATGGCAGGCTTTATCACTCAGCCCGGAACCGGCTACCAGGCCAATTCCGGCAACGTTTTCATCCCCGAAATCTGGACCGCTGAACTCCTCCAGGATCTTGAGGAAGAGCTGGTTCTGGCTTCGGCTCGGTTCACCAACCGGCAGTAGGAGGGCGAGTTCCGCCGGGAAGGTGATGTCGTCCACATCCCGCACTTCGTCAATGACCAGGTGCAGGACAAGGGGCTTGTCCCGGCGTACGGCACGATCGGTTCGCCCGACCACGCGTCCCTCCAGTACATCGATATGCGAGTCGCCAAGGGCTCATCTTTCCATATCGAAGTGGACGCGCTCCACCAGCTCCAGACCAGGGTCGGTATCGACCTGATGAGCAACCTCATTGCTCAGCGGGCTCGCGCCATCGCCATCAAGCTGGATGAGCTGGTCGCCAAGACCCTGCTCGCCGCAGTGAGCGGCAAGGATCTGAACGGCAATGCCGATGCGAATGCGGCGGTTTCCGGTCTGACTGCTCTCCATGGCCAGATTGACGAGATCACCGACGCGCCGACTGGCGACAACGTCACCCGGGTTGGGGGCAAGGAACGGCTGAGCGTCTATCACTACGTGGTGGCGATGCTGGAGAACCTGGATATCAAGTCGGCGCCGGCCGACCGGTTCCTGTTCATTTCCCCGCGCATGCGGTCACTGCTGCTGCGCGACCCGAACTTCATCCAGGCGCAGGTGTACGGCGGTTCGCCGGTCATCCCGAACGGCGCTTCGGCGATCGGCACCATTCTCGGTGTCCCGGTCACTGTGGCCAACGCGCTGGGTTCCCACACCCGGCCGAACAACCCGCTCATCAAGAAGGGCAACCAGGCGTTCCAGCCGGTTGACTTGTACATGGGTGCCACCGCGGCTACGTCGGTCGTTATTCCGTTCGCGCAGATGGAGGCGTACAAGCCGCAGCAGTCTTTCACCGACGCGATCAAGTCGCGCGTGATCTACGACGCGAAGGTCATCCGGCCGGAACAGCTCGTCGTGGCGCGCAACGTCGAGGCCGCCATTACCGCGCACAACGGCGCCAGCACGACCCCGGCCACGACCTGA

Protein sequences of DBSCAN-SWA_2

>NC_016111|1773245:1791486|1783633_1784041_-|WP_014142418.1|DBSCAN-SWA
MIVVTGASDTAEETRQLSLFSALEEASQRPPSRERQEAALAAIDQSKLVSVQQDASTFGVLIMRTLAKPVGEYIDVIVTDQIQAAGYARLRRLEAELGASLFDLEVERGAFQYPHAAILGSRFFEFIRVSKVVMG
>NC_016111|1773245:1791486|1784300_1784798_-|WP_014142419.1|DBSCAN-SWA
MKRLLPDDTILLKHYRDGLSNRQIAELYGVTVQAVAKRLDNLGIKRYPYANAATAIFEAAWPNGETGRVQFTDRSRARSLHVFLRRRLGDPTLSVNQRYVAELFERKVREEGVVLDFDRAHPEGPWVFVHRVEADGRRVIRWPEGKELPPGDLAQALDLPSKPWS
>NC_016111|1773245:1791486|1779863_1780055_-|WP_106433107.1|DBSCAN-SWA
MTLEEHARAIEAAIKAAYADGYELDNGDCSPIHAMDLNTVNDGWLGRYVEIDLPEPTYSRGAM
>NC_016111|1773245:1791486|1778150_1778711_-|WP_014142406.1|DBSCAN-SWA
MTDLDWGQLSELAGKVAREIANKWCVVEVDDVKQEILLHAMEERRTLAEHAEDHEFIRKVFWNAGRRYAAKERAYRDLMDDQYYYTPDEVRTVLRTFVYTDDEIGDVVGKKDDLTRCVISDNIMPARLDAAAALPKLSNEYQELIQRLYVYGMPPVNDAERRRGYRAVDALALSMNRHIRTKRGAA
>NC_016111|1773245:1791486|1786255_1786687_+|WP_014142422.1|DBSCAN-SWA
MTRGPRPKPNAVRRNAHPHAQELAAEAREGRPLPKALGIQTSGARRFWRTWARAPQTATWVETDWAELEITAKLVDALYMGDLKLAPEIRQRVAKWGATVEDRARLRMSLKDEDQDQDDAGPESAAPAASDMDEELYRLLNGP
>NC_016111|1773245:1791486|1780996_1781380_-|WP_041824523.1|DBSCAN-SWA
MSSKPPIALVLKHYYGIQLRDRSGWQKILCPLHPETNPSASANTGFQRWACFVCDVSEDSYDVIQREEGFGFRQAQEFADSRFGTGSEDVPLAVQGESGRGVHEGSGAGRRRRPVSNRIRRFGSYWP
>NC_016111|1773245:1791486|1787439_1788288_+|WP_014142425.1|DBSCAN-SWA
MVRQGFWLYDCLEGNIQPDELRDEAKVRQALTEAYGDATWADIDGLTRTILHDRTTPDSTYLRFFFNAIAESSDGWMVRAEWLACYDDQDPIKPGDQIAVGFDGSIRGDATGLVGCRLRDGKLFVLGIWENPRDPNNPDWEVDVLAVEAAVHRAFKTYRVQWFYGDPPYWQENLGRWALEYGDDYVYEFWTNKPTRMVQAVERFRTASMVQDLKHDGDEDLTRHILNAVTREVPQGLLITKDSPRSKKKIDLAVCAVLAFEARADAIADGRLTIKRKRVVGF
>NC_016111|1773245:1791486|1781512_1781923_-|WP_014142415.1|DBSCAN-SWA
MVTTAKANKDKGYRWEKQALDHIRAAFPEIDPEEIRRHGTLYGVNDRGDITLAPLAFVFEMKNVQRFDLARFMRELKRELEHNPQATNGAVVIKARLKGTGEAYSVMPFDSLLSLVRENWDLKRLLRQERQLRKAG
>NC_016111|1773245:1791486|1773245_1775042_-|WP_014142401.1|DBSCAN-SWA
MKHLHYKIKHQQVRINVVETTDDIREFDRWLGKNPVLGFDTETTGLNWWDWDRGFRLRLAQFGNGSESYVIPVELGEPYRRAAQRALLGAGTLIAHNAIFDQHVIEASLGIPLEVLAPKTICTKITAHLVDPRGVKEKGPGLKLEELTKHYIDPVVAEEVKGSMVLLARKYKTTKHKIWPIVELFDEDFLLYAGMDPILAYRLFHILWPLVPARTKRRGLFSWEHRLNHVTGLIERTGYLLDSDYAEARLAELAAEYERWEQVANRYGVENINSTAQLVDAFLGFGIRLTKKTAKGNLAMDDDVLNGIDHPLAEAVIKARRARKWSATWFQRALDGRDSRGRVHASINSIQARTARMSITGSVPAQTFPAGDGYVRHMFLAEEGHVSVSIDFGNMELRDLAAFSQDPTMLHAFANGLDLHQITADAAGVPRKVGKGANFLTVFGGGWRAMVEQFGVDEETAKRTLSAFADTYPRVGVLAKQLADEARRTGFVYTPTGRRLPVDRGRAYAALNYFIQSGSRDITARALLRLADAGFAPYMRLPIHDEILFSFPRDAAAELTREAARLMEFTIRGVLIPAEGEIGDRSWGSVLELEESKH
>NC_016111|1773245:1791486|1788858_1789776_+|WP_078590657.1|portal|DBSCAN-SWA
MNLWLPDAVWSFAKGSLAWGEGQEGPNPLGVVPVVPISNRSRLLRDPVSDLHVVIPIQDAINKTVADALVASEYAAWPQRYVTGLEIVEDEHGNPVEPFKVAVDKLLQAEDPQAKFGQFEAADLGNYVTLVEMLVQHMASISRIPFHYFLNGGVVPSGESITAAEAGLIAKTRERMLHFGEAWEEVMRLCFKVLDDPRSKAYSAETIWKDPENRTEAQHMDALLKLQMIGVPRDQLLSDAGYTPQQIARFQDMREADAKAAMELAKKYPMPVPEPPAGPVGMSKAAQQTAVKRPQGNSGNQARKS
>NC_016111|1773245:1791486|1778707_1779058_-|WP_157894813.1|DBSCAN-SWA
MSMWKGREYRSKMSGLSFFTVAEPFEHGGTEYVAYIGDEWASPQIAKCALFGVGGVFERVLSPKYQIEQKVEVYCCEGKIVGVASEPDRDGDFTYIVRYPDGSTELAWESAMKAVA
>NC_016111|1773245:1791486|1779054_1779609_-|WP_014142408.1|DBSCAN-SWA
MLEGNHDERPRKYLASRAPALAAEDTFYRFETLLDFPAFDVKKAEPYYPLAPGWVAVHGHESPGMSQVAGATARLKAAKAGISIVMGHTHRLAIAPHTTGHNGKLRTIYGFEVGHLMDVRQAGYLKNGPANWQKGFGLFYVGKYNATPHAIPIEDDGSFVVEGQRYGEIKRGPRGKFISKGGKA
>NC_016111|1773245:1791486|1789820_1790390_+|WP_014142428.1|DBSCAN-SWA
MTDTNDNTSSSSAEQSAPGEQAPTIETLQAEVEKWKSLSRKNEDRFKATSAELDQVRQASMTDAEKAIEAARAEARNATLAEVGTRLAEAELRAHAATAGVELPPAEFLNLSRLVGSDGSVDSDALTKLIASLPKRSNKPVYRQDLGLGRQGDPTAGQLTREEVSRMTGPQIMAARKEGKLDALMTGQF
>NC_016111|1773245:1791486|1780051_1780477_-|WP_014142411.1|DBSCAN-SWA
MKLKFGLDDEVTICPPKGREYSFVLRERKGQTGTVADIDSRYFLPYEVMFPDGRRYMFAEDELMPASTEPSTEEEGIDHPGHYTWMPGGMEVIEITRHFSFVRGNALKYLMRAGRKGDELEDLKKARWYLDYEIESLKVAD
>NC_016111|1773245:1791486|1775590_1776100_-|WP_014142404.1|DBSCAN-SWA
MSYPDPFEDKSPWDVPSHQTTTAKKETAPMPETSRHLARFKIGFTLKAGSGYDAEWLTPTVYGDTAEDTARAGAALLNALKAEGLIDLTAKAADYTRSQFKGGAGGTGPKTFQNGKVVPKTPPAVAGDDCPHGRSLVEKANWAAMFCNGPEGGKCEPLWRQKDGGFKAK
>NC_016111|1773245:1791486|1776144_1778154_-|WP_014142405.1|DBSCAN-SWA
MTAWRTETARTVYERTYSRELPSGELETWPQTVERVVDGNLALVDEQFIEPDERERLVELIETFKVLPAGRHLRGSGVTDYALNNCWAAGWDPARPEEHFTFTLLRLAEGGGVGANYSNRYFAEFPAVENALQVHIVCDPAHPDYTEMAEAGLLSGDYAYTWHVAYAVEDSREGWAAALADLIRTAHNPQVRHTDRVYDVSRLRRKGAALRSFGGTASGPAPFAELLIRTGEILADCAGFPLTGMDAMEIDHEIARCIVAGGVRRSARMSVMHWRDSQIEEFVRCKREQSEHWTTNISVEVDSEFITMAEAGDPAARKVLTTIAEGALRDGEPGFWNSSLSAVGEPDGTYTVNPCGEATLNQWEPCNLGSLNLAAFVEDGRPDWEELDEAHRLLTRYLVRATFAPVADRRSAEVIARNRRIGVGHTGLADYLAKQGIPYSQAAHHDHGLVAYDLQTYAAVVDRAAQEYAAQLRIPVPVKRRVVAPTGTISKLAGVSGEGIHAPYAGYFVRRIRFSLLDPAEAAQVEEYRRSGYHVEPCIYAANTAVVAIPTRDVLLDEVLEQAYEHAGQLDLDAMLSVQEMYQQCWADQAVSYTAVIDPDQYTVEDLAGVLLHYMPRLKGSTVFPESSRAQAPYERITAEEYERLTADLDHRAVDTSYDEDCTSGACPI
>NC_016111|1773245:1791486|1779609_1779840_-|WP_014142409.1|DBSCAN-SWA
MQAPFEDKRALRNVLAFIGDYQPDEVIQIGDLVDYPAPSRWSAGTRAEFEGNVIRDSEYTKRNFLAPLREVYSGPV
>NC_016111|1773245:1791486|1780473_1780983_-|WP_014142412.1|DBSCAN-SWA
MLVIPYLRPAGGEHGVATVRCRCIADECVKDEAGRYLAPLQKERHQGHGKYRSLPGDVPRLYNTMALIGSSPNVVVTEGEMDAMTWEAAGVPAVGYQGTSAWRAHFDPAFMGFRHVYHVADGDEPGIAAAEKRAAEMPNAKVIIPAPRHDSNSFAYEYGFDVLRERIGL
>NC_016111|1773245:1791486|1790403_1790550_+|WP_157894815.1|DBSCAN-SWA
MAGFITQPGTGYQANSGNVFIPEIWTAELLQDLEEELVLASARFTNRQ
>NC_016111|1773245:1791486|1790610_1791486_+|WP_014142429.1|DBSCAN-SWA
MQDKGLVPAYGTIGSPDHASLQYIDMRVAKGSSFHIEVDALHQLQTRVGIDLMSNLIAQRARAIAIKLDELVAKTLLAAVSGKDLNGNADANAAVSGLTALHGQIDEITDAPTGDNVTRVGGKERLSVYHYVVAMLENLDIKSAPADRFLFISPRMRSLLLRDPNFIQAQVYGGSPVIPNGASAIGTILGVPVTVANALGSHTRPNNPLIKKGNQAFQPVDLYMGATAATSVVIPFAQMEAYKPQQSFTDAIKSRVIYDAKVIRPEQLVVARNVEAAITAHNGASTTPATT
>NC_016111|1773245:1791486|1782839_1783628_-|WP_042507623.1|DBSCAN-SWA
MSVETQPRSVSQVQQYEECGWRYYLARVERVTPRPAAWSFHGSAFHAVAEAVVLSNGRMTAEEAVEAFSDKYARLVQDALDIEPDTDRWLSSGRYSGGEEIERRYVLGQEQTAQYVDWVAEHRPEVWTTPAGKPAVELGFTVELGGVVVRGIIDLLVMEADGDAVRVRDLKTGSIKSRFQLETYAVAIESLYDVPVRRGDWYLAKDGRLSRPVALDQVSPAEVGERYATMDAGVKAGRFEANPGYGCRFCDVSHGCFFYATS
>NC_016111|1773245:1791486|1786872_1787394_+|WP_014142424.1|DBSCAN-SWA
MLWFYAINPDGTWRYSAGTLRRAKGWGKTPLLAALAIVEFIGPCRFDRFDAFGLPVAKRVPLPTVQIGATALDQTDQTLEMIRGMLSESPAEKEYGLEIGKSVIQFKSGKPGSIRPKATAGRTNEGNRPTFALLDEVHHWVGSNGGPDFYQVIKRNVEKTASAGSRWVTTTNA
>NC_016111|1773245:1791486|1788480_1788837_+|WP_014142426.1|portal|DBSCAN-SWA
MFSQARHYNHFHQTFESWRDNFCGLIIDSVNERLTVDGFRMTDEPDADKDARDIWQRNYMDAEHNAAQLDAMIQGASYAVVWSDDDDQPTITMESAENVVVQYKPGSRRELAAAAKFY
>NC_016111|1773245:1791486|1781995_1782814_-|WP_014142416.1|DBSCAN-SWA
MYSLTQSVEVKGSAGEPIPNPFAGLRRQEVEFRRGELSLVAAGPGTGKSLFAINLALFGNLPVLYFSADSNAATQLTRATAILTGDNVREVKRKLIADEFGEYHAALGERWWIRFNYEARPTPGDIEQDLACYYEVFGIYPYLIVVDNITNVDGGDGQADAGNFSFGLEAMCEYLSEMARDTQAHVLGLHHVVGEFSDGLRPIPLSGVKGKIGRVPSVILTIHKEIDGMDGRLLHVSPVKNREGFEDSSGQTFTTYEFNSANMRLTDLESEF
>NC_016111|1773245:1791486|1775210_1775393_-|WP_014142403.1|DBSCAN-SWA
MTEANRILVYGLENGGVDLWCAKCETQIASGGCACCDNNAVTAQDIATATTAHHCKESAP
>NC_016111|1773245:1791486|1785583_1785754_+|WP_173405690.1|DBSCAN-SWA
MLVRDRFRCQFCGSPRKLEVDHIIPVSRGGSWEPDNLWTLCQSCHKRKSHHDRQSR

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014142401.1|1773245_1775042_-	DNA polymerase	A0A220NQB6	Rhodococcus_phage	1.7e-162	51.5
WP_014142403.1|1775210_1775393_-	hypothetical protein	NA	NA	NA	NA
WP_014142404.1|1775590_1776100_-	hypothetical protein	NA	NA	NA	NA
WP_014142405.1|1776144_1778154_-	ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent	A0A0N9RS78	Mycobacterium_phage	9.0e-208	55.6
WP_014142406.1|1778150_1778711_-	hypothetical protein	NA	NA	NA	NA
WP_157894813.1|1778707_1779058_-	hypothetical protein	NA	NA	NA	NA
WP_014142408.1|1779054_1779609_-	hypothetical protein	A0A2P1JTH8	Mycobacterium_phage	1.6e-37	51.2
WP_014142409.1|1779609_1779840_-	hypothetical protein	I6WID8	Mycobacteriophage	1.7e-25	69.3
WP_106433107.1|1779863_1780055_-	hypothetical protein	NA	NA	NA	NA
WP_014142411.1|1780051_1780477_-	DUF3310 domain-containing protein	G9FHE1	Rhodococcus_phage	1.4e-14	33.1
WP_014142412.1|1780473_1780983_-	toprim domain-containing protein	A0A088FWB0	Mycobacterium_phage	1.0e-30	44.6
WP_041824523.1|1780996_1781380_-	hypothetical protein	NA	NA	NA	NA
WP_014142415.1|1781512_1781923_-	hypothetical protein	NA	NA	NA	NA
WP_014142416.1|1781995_1782814_-	AAA family ATPase	A0A2K9VI58	Mycobacterium_phage	6.1e-62	47.2
WP_042507623.1|1782839_1783628_-	PD-(D/E)XK nuclease family protein	A0A0K1LJJ9	Mycobacterium_phage	1.5e-46	41.0
WP_014142418.1|1783633_1784041_-	hypothetical protein	NA	NA	NA	NA
WP_014142419.1|1784300_1784798_-	sigma-70 region 4 domain-containing protein	NA	NA	NA	NA
WP_173405690.1|1785583_1785754_+	HNH endonuclease	H6WG01	Cyanophage	1.4e-08	51.1
WP_014142422.1|1786255_1786687_+	hypothetical protein	A0A2P1CID7	Actinomyces_phage	1.8e-09	52.5
WP_014142424.1|1786872_1787394_+	hypothetical protein	A0A2H4J271	uncultured_Caudovirales_phage	2.3e-30	38.2
WP_014142425.1|1787439_1788288_+	hypothetical protein	A0A1B3AY92	Gordonia_phage	2.2e-51	37.1
WP_014142426.1|1788480_1788837_+|portal	phage portal protein	A0A291AUY2	Mycobacterium_phage	4.1e-07	33.0
WP_078590657.1|1788858_1789776_+|portal	phage portal protein	A0A1B1IN58	uncultured_Mediterranean_phage	1.8e-30	31.3
WP_014142428.1|1789820_1790390_+	hypothetical protein	NA	NA	NA	NA
WP_157894815.1|1790403_1790550_+	hypothetical protein	NA	NA	NA	NA
WP_014142429.1|1790610_1791486_+	hypothetical protein	D7NW53	Streptomyces_phage	6.8e-11	29.6

Sequences of DBSCAN-SWA_3

Nucleotide sequences of DBSCAN-SWA_3

>NC_016111|1798378:1804934|DBSCAN-SWA
CATCCAGGTCGAGTCCGGCGGCAACCCGAACGCCATCAATTTGTGGGACAGCAACGCCCTGGCCGGCATGCCGAGTCAGGGGCTCATGCAGACGATCCCGCCCACGTTCGACGCCTACGCCGGTCCGTACCGCAGTCTCGGGATCACCAACCCTCTGGCCAGCATCTATGCCGGTCTCAACTACGCGATCCACCGCTAGGGCGCCGGCTGGGTGCAGGCCCTCGCCGGCACCGCCGGGTACGCCTCAGGCACCTCGGGGGCACGGCCCGGCTGGGCCTGGGTCGGCGAGGAAGGCCCCGAACTCGTCCGGTTCGGCGGCGGGGAGACGGTGCTGAACCACCGGGACTCGATGCGGGCCGCAACCCGTGGCCTGCCCGGGTACGCCTCGGGCACGAAGTCGGGCGTGGCCGTCGACGCGGAGAAGGGCGCGTCCTCGCTGAGTGCTGCGGTGAAGCGGCTCTACGAGATCATCACCAAGGCGTTCACGTCCGGGCGGATCGGCCAGGGCACGGAGAATTCGCTGAACCGCTGGCTCGACGGTGAGAACAAGGCACTGTCGAACCTGGTGAAGCAGCGGACCGACCTGGCGGGGAAGCTGAAAGCGGCTCAGGCCGCGTTGAAGAAGGTCAAGGACGACGAGGCGAAAATGGCCTCGGGGATCTCCGACAAGGCATCGTCCCTGCGCGACCTGTCATCGGTTTTCAATTCCGATGGCGTGTCGGTGACTGCTGGTCTGTCCGGGCTCCACGAGCGCCTGGCCGCCATCAAGAAGTTCCAGGCCAACCTGAACACCTTGGTGAAGCGGGGTTTCTCGTCGGCAATCATCGAGAACATCGCGGAGGCCGGTCCGGAACAGGGCGGGGCCATGGCTCAGGAACTCCTGAACGCCACCGGCGCCCAGATCAAGGACTACAACAAGACGTACGCAGCCATCGGCACGGCGTCCGATTCCCTCGGGAACTCGGTAGCCAAGTCCTACTACGCCACTGGCGAGAAGGCTGCTCAGCGTCTTGTCGATGGTCTGATGTCCAAGGACAAGGTATTGGTCAAGAAGATCGAGTCCCTTGCGGATTCGATCGTCCGGACGCTGAAGAGGACGCTGAATTTCGGCTCCACCACACCGGTGACCTCCGGTCTGGGTGCTCTGCTCACCTGGCTCACCGGCGAGTCGCAGAGCGTCGGGCGCAAGCCCAAGCCGAAGCCCAAGCCCAAGCCCAAGCCGACGCCGCAGGTCAAGCGCACGGTCACGACCACGACGGGATACGACTCCAAGGGGCGGTCCGTCACCACGGTGACGACGACCATCACGGATCCGTGGGCCGGTACGACCACCACCATCACGGAGCGGACCGTCGACGGGCGGACGACCACCACCCGATCCGTCCGCAGGACGACCAAGGGCTACGCCACCGGCACTCTTTCCGCCTCGCCGGGTATGGCGCTGGTCGGTGAACGCGGCCCGGAACTCGTGGACTTCCGCGGAGGCGAGCGCGTCTACACCGCACGGCAGACGGCCGACCTGATGGGGCCTCGCTACGAGATCCACATTCATGAAGCGAAGGCGGAGAACACCACGCAGGCCGTTCTCCGCGCGCTGAAGTACGCGGAGGTGATGTCAGGAATGTAAAAGCGAAAGGAGTGCTCCATGCCGATTCCCGCAGCGGTCACGTCCCCCAACGATGCCTGGTCGGGGGATTTAACCGTCCCCGTTCCGGTGGAGTGGCAGAGCACCTACGTATCGATCCGAGGGAACAACGGTCAGGGGGAGGAAATCCCCCTGACCGGTTTCCTGTCCGCGGCATGGCCGGCCATCATGCTCCAGCCCGGGGCAACCGGGCTGGACATGCCCCCGTTCGAAATCCACGCCGACGACTCCCCGAACCTGGACGGCTCGATGTACCGGGGAGCACGGGCAGCGGCGCGGGACATCCTGCTACCGCTCTACGTCTACGGCATCGACCGCCTGACGCTGCGCCAGTTCAAGAGGGATCTCGCCAACGCGCTCAACCCCAAGTCGGGTTACTGCGTGCTGACGTTCATCGAATCGGACGGCATTCCGCGAAGGCTGCGCTGCTACTACAAGGGCGGCATGGAGGGGAGCGAGGCCGCCGACTCGGCCGGGTTCCGCTGGGTGTCCTACGGAATTCAGCTCACCGCCATGGACCCCTGGTTCTACGGAGACACACAGGTCGTGGCGAGCTGGTCATTCGGCAAGCCCCAACCCTTCCTCGGCAAGTTCCTTCCGTTGCGGCTGGGCAAGGGCACGCTGGCTACCAACACCCTCCAGGTCAGCAACCCTGGGGACATCGAGGCGTGGCCGGTGTGGCGGATCTCCGGGCCGGTCAAGTCCCTGATCCTCACGGGCCCCGACGGCTCTTCCTGGGGAATTCCGGCGCAGGCCAGCGGAGCGGACGTGATCCCTATCGGGCGCACGCTCACGGTGGACTGCCGTCCCGGCTACAAGACCGTGACCGATGACCAGGGGAAGAATTATTTCCCGCTGCTTGCAGCGAATCCGTCGCTGTGGCCGGTGCCTCCGGGAACGTCAACGGTCGCTACGAATCTGGTGGCCGGCAGCGGCACCGCGGCCGTGACGATGACGCTGGATCCCCGCTACGCGAGTTACTGACGAGGTGCACTGATGGGTTACCGGGTGGAGGTGCGCGACGCCGCTCTCAACCGCATTGGAGTGATCGACACATGGATTAAATTGGATCTGGTGGTGCGTTACTGCCAGACCGGTTCCTGGCAGGTTCTCGTGGAGGCGGGAACACCGCAGGCGGACCTTCTCCAGAAGGGCGGCGGAGTCGCCATCTACCAGGACGGGGTGAAAGACCCGGTTCTCACTGGGCAGATCGAGGCGTTCCAGCATTACTGGACCAATGATCAGCACACCTCGCTCGGCTCCCTGTATTTCGGGGGGAAGTGCGACAACAAGCTTGCCTACAACCGGCTTGCGTTCCCGGACCCGGCCAAGGACGCCACGCAGCAGTGGCAGGCCGACGACACCCGCAAGGTCAAGGGCCCGGCCGGCCAGCTCATCTGGTCGGAGCTGAACCAGGCCCTCGGGCCCGGGGCGCTGCCCAGCCGGCAGATTCCCGGGGTCGTGATCGGCAGCAACGTCCCCAGTGGCCCCACGCTTTCGGACAACCTCCGATGGGATGTGATCGGGACCAAACTCGAATCGTGGATCGACACGAAGACGACCGGTTACCGGTTCCTGTACGACCCCAACGCCAAAGCGATCAACTTCCACCCCTTCACGCCCCGTGACCTCTCGCAGGACATCCGGTTCAGCACCGAGCTGGGCAACCTGCGGGAATTCACGTGGGCGCTCACCGCGCCGACGGTGACACGGGTGATCGTGGCGTGCCAGGGCGCAGGGAAGTCACGCTACCTCTATCAGCAGACCGACACCGCCAGCGAAGCCGAATGGGGGCTCCAGATTGAACAGTTCCTCGACCGCCGCGACCTACCCATCAAGGCGGACCCGACGACAGGACAGCCGATCAAAGCCGATCTTTCCGTTTCCGACACCGACTTCCAGACCGCACTCCAAGCCGTCAAGGACGCGGCCAATGAGGCGCTGACCAACGGCGCCAAGAACGGCAACTTCCAGATTTACCCCATCGACACCGATCACGTGAAGTTCGGCCGTGATTACTTCGTCGGGGACATCGTGACAGTTGCCGTGGACGGCACCGAATACGTGGACATCGTCCGTGAGGTCTCCATCACAGTGGAGCAGGGCGGCCAGACGGAAACCGTCGCCCCCTCGATCGGGGAGCAGGGATCCGGCAACCCGCTGAATCTCTACAAGACGGTATTCGAGATGCGCGAGAAACTGCGCAGGCTAGAGGCAAGGATGTAAATGGGAAACGAGATCAGCTACCCGTTCAGCTCGGACTCCGCCGGTGGCGGACAGCAGATGGTGTCCCAGGCGCAGTGGCAGATGATGAGCCGCATGTTCGGGCCGGACCGCATCGACACCCAGCTCGTCAGCAGCAGCTACGACGGTTCAGCCCTCCCGTTCGCGGCCTCCGTCGTCAACGGCACGTCAGTCTCCGTCTCCCCCGGCCGCGCGCTGGTCGGGGGCTTCTACTACCAGCTCACCGCAGCCCAGAGTGTGGCCATCGCCGCCAACACCGGGACGAACCCCCGCGTCGACCTCATCGTGCTCCGGGCCGACCTGGCGGCCGGCTCGGTGAACCTCGCCGTCGTCCAGGGCCAGGCCGCGGCCTCCCCGGTCGTGCCGCAGCCCACACGCACACTCGGCGGCCGGTGGGAGCTGCCCCTGCACCAGGTCACCGTACCCGGCAACAACGGCACTCTCAGCGTCCTGTCAGTGGGCCCGTTCGACATGCCGTCACCCGTCGCCGTGCCGTGGAACGCGTCGCAGCTCGCCCAGGTGACACCGGTCGGCACGTACATCTACGACCTGGACAGCAACACCAACGACACCCAAAGCGAGTATTTCGTTGGCCGGGACGGTGTTGCTGTGACCCGGCACCTGGGCAAGGCACGCCCGTACACCCCGAGCCTGGTCAACGCTACGGATCCGCTGCCGACTTCCTACCGCACGGGCCGGTGGCGCATCATCGCGCCGGGCATGGTCTGGTTCGCCGTGACCATCAACAACCAGAACGACGGCGGCGCAATGCTCAGCGGGAAGAACTGGATCATGGGAATCACCCTGCCTCCGGTCCCGGCGGCAACAGCGACCCGCCAGGTACTCCACGGGCACATCACCAACGCACGCGGCGGCGGCAACCTGCCCAACTACATGTCTGTTACCGCACTGATCGAACAGGGCGGCACCGGGCAGACCACCGCCTACCTGTACTACCCCAGTCCGACCACCCCCGCCCAGGGCCTCGACGCACTGCCCGGGATCCCCGCCGGAGCCATCCTCACCCTGTCCGGGGTGTACCAGACCAACGTCTACGGAGACTGAATCATGCGACAACTCTTCGGCGGGACAGCGTCCGACTTCGCCGAGGACGCCGCCGGCACCCGCGTACCCGGCGCCATCGGAACCGTCTGGGACGGGCCGAGCACGGGCGCACAGCAGTACACCGACCTCACCACCGCTGATGGCGCCCCGATGTACCAGCTCACTGCCGACTCACGGGGGTTCGTCCCGGCCTTCTTCGGCCCGGATGGCGTCGAGAGGCTGTGGGTCGATTTCGGGGCCGGCCGCGTCGCGCTGACCTCCGTGACCGTCGGCGAACGCCTCGACGCCCACACCAGCGCCCTCGACCCGCACGGCGACCGCGCCTACGCGGATGGCGCCTTCCTCAAGAACAGCGGCAACGGCCTCGAAGTCACACCGGACGGAAAGGCCATCGTCAGCCACGTTCCCCACCAGTTCACCGGACCTCTGCGGCTCTGCTCGGCGAGCGGGGATCTCCTCGGGGAGCTGTACGCCGAGGGCGGCGCGCTGAAGTGGCGCAGCTCCGCAGGCACCGTGACCACGATCGCCCCGGCGTAAGGAGACTGCTCGTTGACCCCTCAGACCATCACCAACTAGGCCAGCATCGCAGCAACAACCATCGCTGCCCTCATTTCCCTCGCCGCGGCCGTGAAGTACCACACCGGCCGCGTCTGGCAGGCCGAGGCGGAAGCTCAGAAGGCACGAGCCGACCGGCTCCAGGACGACCTGGCGGAGATCAAGGAACGCCTCGCTCGGATTGAGGCCGAGAACTCTCGGCTTCTGGAGATCCTGTCCGTCATCGACCCTGAACGCATCGCCGCCCTGCGGCATCCCTGACCCCAGCAACTTCCCTGCGGGCCGCCCACACCGGGCGGCCCTTCCTCATACCTAGGAGAACACCTTGATCAAGGGCATCGACGTTTCCTCGTACCAGTCCACCGACTTCGACACTGACGGCCTCGACTTCGTCTTCATCAAGGCCACCGAGGGCACCTCGTACGTCAACCCGCGCATGGCCGGCCAGGCGGCCACCGCCCGCGCCGCCGGCCTGGTGGTCGGCTTCTACCACTACATCTCACCGGGCGACATGTCCGCGCAGGCCGCCTTCTTCGTGGACCGGTGCGACTCCGTACCGGGCGACGTCCTGTTCGCCGACTGGGAAGAGCCGGGCGTGTCCTGCGCTCAGAAGGACCAGTTCATCCGCGAGGTGAAGCGCCTGCGCGGCTCGAACCACAAGGTCGGCCTGTACTGCAACCAGGACTACTGGCTCAACCGCGACTCCAGCTCGTACGCCGGTGACGCCCTCTGGATCGCCGACTACGTAACCCCGGGGCGCCCGCGCATCCAGGCGAACTGGCTCTTCCACCAGTACACCGACCGCCCGTTGGACACCAACGTGGCCAGCTTCGCCAACCGCGCGGCGCTGCGCTCATGGGCGGGCGGCAGCTCGGCGCCGGCCCCGAAGCCGACCCCGGGACCGGTCACGTACACGGTCCGCTCCGGCGACACCCTCTCCGGCATCGCGCAGAAGTACGGCACCACCGTGGCGAAGTTGTCGGCGGCCAACGGCATCAAGGACCCGGACATGATCTTCGCCGGTCAGGTTCTCAAAATCGTGAAGTGA

Protein sequences of DBSCAN-SWA_3

>NC_016111|1798378:1804934|1802248_1803331_+|WP_014142445.1|DBSCAN-SWA
MGNEISYPFSSDSAGGGQQMVSQAQWQMMSRMFGPDRIDTQLVSSSYDGSALPFAASVVNGTSVSVSPGRALVGGFYYQLTAAQSVAIAANTGTNPRVDLIVLRADLAAGSVNLAVVQGQAAASPVVPQPTRTLGGRWELPLHQVTVPGNNGTLSVLSVGPFDMPSPVAVPWNASQLAQVTPVGTYIYDLDSNTNDTQSEYFVGRDGVAVTRHLGKARPYTPSLVNATDPLPTSYRTGRWRIIAPGMVWFAVTINNQNDGGAMLSGKNWIMGITLPPVPAATATRQVLHGHITNARGGGNLPNYMSVTALIEQGGTGQTTAYLYYPSPTTPAQGLDALPGIPAGAILTLSGVYQTNVYGD
>NC_016111|1798378:1804934|1798588_1800004_+|WP_014142442.1|DBSCAN-SWA
MQALAGTAGYASGTSGARPGWAWVGEEGPELVRFGGGETVLNHRDSMRAATRGLPGYASGTKSGVAVDAEKGASSLSAAVKRLYEIITKAFTSGRIGQGTENSLNRWLDGENKALSNLVKQRTDLAGKLKAAQAALKKVKDDEAKMASGISDKASSLRDLSSVFNSDGVSVTAGLSGLHERLAAIKKFQANLNTLVKRGFSSAIIENIAEAGPEQGGAMAQELLNATGAQIKDYNKTYAAIGTASDSLGNSVAKSYYATGEKAAQRLVDGLMSKDKVLVKKIESLADSIVRTLKRTLNFGSTTPVTSGLGALLTWLTGESQSVGRKPKPKPKPKPKPTPQVKRTVTTTTGYDSKGRSVTTVTTTITDPWAGTTTTITERTVDGRTTTTRSVRRTTKGYATGTLSASPGMALVGERGPELVDFRGGERVYTARQTADLMGPRYEIHIHEAKAENTTQAVLRALKYAEVMSGM
>NC_016111|1798378:1804934|1800022_1801006_+|WP_014142443.1|tail|DBSCAN-SWA
MPIPAAVTSPNDAWSGDLTVPVPVEWQSTYVSIRGNNGQGEEIPLTGFLSAAWPAIMLQPGATGLDMPPFEIHADDSPNLDGSMYRGARAAARDILLPLYVYGIDRLTLRQFKRDLANALNPKSGYCVLTFIESDGIPRRLRCYYKGGMEGSEAADSAGFRWVSYGIQLTAMDPWFYGDTQVVASWSFGKPQPFLGKFLPLRLGKGTLATNTLQVSNPGDIEAWPVWRISGPVKSLILTGPDGSSWGIPAQASGADVIPIGRTLTVDCRPGYKTVTDDQGKNYFPLLAANPSLWPVPPGTSTVATNLVAGSGTAAVTMTLDPRYASY
>NC_016111|1798378:1804934|1801018_1802248_+|WP_014142444.1|DBSCAN-SWA
MGYRVEVRDAALNRIGVIDTWIKLDLVVRYCQTGSWQVLVEAGTPQADLLQKGGGVAIYQDGVKDPVLTGQIEAFQHYWTNDQHTSLGSLYFGGKCDNKLAYNRLAFPDPAKDATQQWQADDTRKVKGPAGQLIWSELNQALGPGALPSRQIPGVVIGSNVPSGPTLSDNLRWDVIGTKLESWIDTKTTGYRFLYDPNAKAINFHPFTPRDLSQDIRFSTELGNLREFTWALTAPTVTRVIVACQGAGKSRYLYQQTDTASEAEWGLQIEQFLDRRDLPIKADPTTGQPIKADLSVSDTDFQTALQAVKDAANEALTNGAKNGNFQIYPIDTDHVKFGRDYFVGDIVTVAVDGTEYVDIVREVSITVEQGGQTETVAPSIGEQGSGNPLNLYKTVFEMREKLRRLEARM
>NC_016111|1798378:1804934|1803334_1803868_+|WP_014142446.1|DBSCAN-SWA
MRQLFGGTASDFAEDAAGTRVPGAIGTVWDGPSTGAQQYTDLTTADGAPMYQLTADSRGFVPAFFGPDGVERLWVDFGAGRVALTSVTVGERLDAHTSALDPHGDRAYADGAFLKNSGNGLEVTPDGKAIVSHVPHQFTGPLRLCSASGDLLGELYAEGGALKWRSSAGTVTTIAPA
>NC_016111|1798378:1804934|1798378_1798576_+|WP_078590659.1|DBSCAN-SWA
MQVESGGNPNAINLWDSNALAGMPSQGLMQTIPPTFDAYAGPYRSLGITNPLASIYAGLNYAIHR
>NC_016111|1798378:1804934|1803958_1804147_+|WP_014142447.1|DBSCAN-SWA
MKYHTGRVWQAEAEAQKARADRLQDDLAEIKERLARIEAENSRLLEILSVIDPERIAALRHP
>NC_016111|1798378:1804934|1804211_1804934_+|WP_014142448.1|DBSCAN-SWA
MIKGIDVSSYQSTDFDTDGLDFVFIKATEGTSYVNPRMAGQAATARAAGLVVGFYHYISPGDMSAQAAFFVDRCDSVPGDVLFADWEEPGVSCAQKDQFIREVKRLRGSNHKVGLYCNQDYWLNRDSSSYAGDALWIADYVTPGRPRIQANWLFHQYTDRPLDTNVASFANRAALRSWAGGSSAPAPKPTPGPVTYTVRSGDTLSGIAQKYGTTVAKLSAANGIKDPDMIFAGQVLKIVK

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_078590659.1|1798378_1798576_+	transglycosylase SLT domain-containing protein	A0A142K904	Gordonia_phage	7.3e-14	63.9
WP_014142442.1|1798588_1800004_+	hypothetical protein	A0A2H5BLG0	Streptomyces_phage	1.3e-11	33.1
WP_014142443.1|1800022_1801006_+|tail	phage tail family protein	A0A0E3DJL1	Propionibacterium_phage	9.3e-17	25.2
WP_014142444.1|1801018_1802248_+	siphovirus ReqiPepy6 Gp37-like family protein	A0A291LHA1	Streptomyces_phage	3.3e-27	29.0
WP_014142445.1|1802248_1803331_+	hypothetical protein	A0A0K0N633	Gordonia_phage	1.2e-09	30.2
WP_014142446.1|1803334_1803868_+	hypothetical protein	NA	NA	NA	NA
WP_014142447.1|1803958_1804147_+	hypothetical protein	NA	NA	NA	NA
WP_014142448.1|1804211_1804934_+	LysM peptidoglycan-binding domain-containing protein	Q8LTJ6	Lactococcus_phage	9.3e-14	30.8

2. NC_016113

CRISPR-Cas detection and classification

Crispr_ID: NC_016113_1

• CRISPR_ID: NC_016113_1
• CRISPR_location: 880010-880164
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers
• Cas_protein_info: csa3

Consensus repeat of NC_016113_1

Consensus_repeat	Method
CCCGCCGCACGCCCGGGGCACCCCCAACCACCCC	PILER-CR

spacers of NC_016113_1

>1.1|880044|46|NC_016113|PILER-CR
GCCCCAACCTCCCGCGCGCCCGCCCCTCACAGCGCGGCCCTCCGAA
>1.2|880124|23|NC_016113|PILER-CR
GGCGCCGACCCCGGCAACCCGGC

CRISPR arrays and Neighbor proteins around NC_016113_1

CRISPR arrays

The CRISPR arrays of NC_016113_1

>merge|NC_016113|1|880010-880164|PILER-CR
CCTGCCGCACACCCGGGGCACCCCCAACGCCCCAACCTCCCGCGCGCCCGCCCCTCACAGCGCGGCCCTCCGAAGCCCGGGGCACCCCCAACCGCCCCGGCGCCGACCCCGGCAACCCGGCCCCGCCGCACGCCCCAGGCACCCCCAACCACCCC

>NC_016113|1|1|880010-880164|PILER-CR
CCTGCCGCACACCCGGGGCACCCCCAACGCCCCA	ACCTCCCGCGCGCCCGCCCCTCACAGCGCGGCCCTCCGAAGCCCGG
GGCACCCCCAACCGCCCCGGCGCCGACCCCGGCA	ACCCGGCCCCGCCGCACGCCCCA
GGCACCCCCAACCACCCC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016113.1|WP_014151246.1|877403_878525_-|FAD-dependent-monooxygenase	unknown	unknown	gnl|CDD|223727
NC_016113.1|WP_014626931.1|881102_882218_+|hypothetical-protein	unknown	unknown	gnl|CDD|366376
NC_016113.1|WP_014151241.1|874023_874947_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|375319
NC_016113.1|WP_014151248.1|880300_880867_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
NC_016113.1|WP_014151237.1|869740_870382_+|hypothetical-protein	unknown	unknown	gnl|CDD|117022
NC_016113.1|WP_014151238.1|870398_871604_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|379258
NC_016113.1|WP_014151255.1|886597_886966_-|hypothetical-protein	unknown	unknown	unknown
NC_016113.1|WP_014151251.1|882438_883665_-|cytochrome-P450	unknown	unknown	gnl|CDD|225035
NC_016113.1|WP_014151256.1|887089_887473_-|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl|CDD|238042
NC_016113.1|WP_014151253.1|884631_885852_+|cytochrome-P450	unknown	unknown	gnl|CDD|225035
NC_016113.1|WP_014151257.1|887581_889558_+|heavy-metal-translocating-P-type-ATPase	unknown	unknown	gnl|CDD|319849
NC_016113.1|WP_014151247.1|878666_879410_+|TetR/AcrR-family-transcriptional-regulator-C-terminal-domain-containing-protein	unknown	unknown	gnl|CDD|172294
NC_016113.1|WP_014151242.1|875069_875762_-|demethylmenaquinone-methyltransferase	unknown	unknown	gnl|CDD|223756
NC_016113.1|WP_014151240.1|872798_873839_-|NAD(P)-dependent-alcohol-dehydrogenase	unknown	unknown	gnl|CDD|176186
NC_016113.1|WP_014151258.1|889554_889962_+|hypothetical-protein	unknown	unknown	unknown
NC_016113.1|WP_014151245.1|876701_877289_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|366102
NC_016113.1|WP_014151250.1|882232_882442_-|ferredoxin	unknown	unknown	gnl|CDD|224064
NC_016113.1|WP_014151239.1|871783_872725_+|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl|CDD|238861
NC_016113.1|WP_014151244.1|875980_876640_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|224584
NC_016113.1|WP_014151252.1|883817_884345_-|hypothetical-protein	unknown	unknown	unknown

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_016113.1|WP_014151256.1|887089_887473_-|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	6.7e-18	59.9	0.3

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016113.1|WP_014151246.1|877403_878525_-|FAD-dependent-monooxygenase	gnl|CDD|223727	COG0654, UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion].	6.36295e-31
NC_016113.1|WP_014626931.1|881102_882218_+|hypothetical-protein	gnl|CDD|366376	pfam00933, Glyco_hydro_3, Glycosyl hydrolase family 3 N terminal domain.	1.47933e-52
NC_016113.1|WP_014151241.1|874023_874947_+|helix-turn-helix-domain-containing-protein	gnl|CDD|375319	pfam17765, MLTR_LBD, MmyB-like transcription regulator ligand binding domain. This domain is found in a family of actinobacterial transcription factors. The structure shows it has a PAS domain like fold and it is bound to Myristic acid.	1.03324e-67
NC_016113.1|WP_014151248.1|880300_880867_-|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.70227e-13
NC_016113.1|WP_014151237.1|869740_870382_+|hypothetical-protein	gnl|CDD|117022	pfam08445, FR47, FR47-like protein. The members of this family are similar to the C-terminal region of the D. melanogaster hypothetical protein FR47. This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.	0.00679427
NC_016113.1|WP_014151238.1|870398_871604_-|helix-turn-helix-domain-containing-protein	gnl|CDD|379258	pfam13556, HTH_30, PucR C-terminal helix-turn-helix domain. This helix-turn-helix domain is often found at the C-terminus of PucR-like transcriptional regulators such as Bacillus subtilis pucR and is likely to be DNA-binding.	5.20712e-19
NC_016113.1|WP_014151251.1|882438_883665_-|cytochrome-P450	gnl|CDD|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	4.15931e-75
NC_016113.1|WP_014151253.1|884631_885852_+|cytochrome-P450	gnl|CDD|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	7.47066e-80
NC_016113.1|WP_014151257.1|887581_889558_+|heavy-metal-translocating-P-type-ATPase	gnl|CDD|319849	cd07551, P-type_ATPase_HM_ZosA_PfeT-like, P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which transports copper, and perhaps zinc under oxidative stress, and perhaps ferrous iron. Bacillus subtilis ZosA/PfeT (previously known as YkvW) transports copper, it may also transport zinc under oxidative stress and may also be involved in ferrous iron efflux. ZosA/PfeT is expressed under the regulation of the peroxide-sensing repressor PerR. It is involved in competence development. Disruption of the zosA/pfeT gene results in low transformability. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NC_016113.1|WP_014151247.1|878666_879410_+|TetR/AcrR-family-transcriptional-regulator-C-terminal-domain-containing-protein	gnl|CDD|172294	PRK13756, PRK13756, TetR family transcriptional regulator.	3.55418e-09
NC_016113.1|WP_014151242.1|875069_875762_-|demethylmenaquinone-methyltransferase	gnl|CDD|223756	COG0684, MenG, Demethylmenaquinone methyltransferase [Coenzyme metabolism].	3.84443e-32
NC_016113.1|WP_014151240.1|872798_873839_-|NAD(P)-dependent-alcohol-dehydrogenase	gnl|CDD|176186	cd05283, CAD1, Cinnamyl alcohol dehydrogenases (CAD). Cinnamyl alcohol dehydrogenases (CAD), members of the medium chain dehydrogenase/reductase family, reduce cinnamaldehydes to cinnamyl alcohols in the last step of monolignal metabolism in plant cells walls. CAD binds 2 zinc ions and is NADPH- dependent. CAD family members are also found in non-plant species, e.g. in yeast where they have an aldehyde reductase activity. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	0
NC_016113.1|WP_014151245.1|876701_877289_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	1.54932e-08
NC_016113.1|WP_014151250.1|882232_882442_-|ferredoxin	gnl|CDD|224064	COG1141, Fer, Ferredoxin [Energy production and conversion].	3.31302e-09
NC_016113.1|WP_014151239.1|871783_872725_+|SGNH/GDSL-hydrolase-family-protein	gnl|CDD|238861	cd01823, SEST_like, SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles two of the three components of typical Ser-His-Asp(Glu) triad from other serine hydrolases, but may lack the carboxylic acid.	1.83911e-45
NC_016113.1|WP_014151244.1|875980_876640_-|GNAT-family-N-acetyltransferase	gnl|CDD|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	3.72597e-22
NC_016113.1|WP_014151256.1|887089_887473_-|winged-helix-turn-helix-transcriptional-regulator	gnl|CDD|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	6.64344e-18

Protein sequences

>NC_016113.1|WP_014151247.1|878666_879410_+|TetR/AcrR-family-transcriptional-regulator-C-terminal-domain-containing-protein
MATRTRRSQRRTEALSRERIVEAAVELLDTVGESGLTFRALTERLATGTGAIYWHVANKDELLGAATEAVVGAALAVEPVAPTTPAAPADSPPDEIRAVALGLFEAIDDHPWLATQLATQLSRSPWGSVTPRIFDSIGRRVRALGVPEDGWFTATSALVHYVLGAAGQNAANSRADGPPKDRAEFLDDVATAWEELDPDDYPFARAVAGQLRDHDDREQFLAGLDLVLAGITALHPPSKPTHPPHTP
>NC_016113.1|WP_014151246.1|877403_878525_-|FAD-dependent-monooxygenase
MRTPVTIIGAGLGGLTLARVLHVNGIAATVYEAEPSPTARSQGGMLDIHDYNGQIALQAAGLRDEFRDIILEGRQAMRILDPAGNVLFDKADDGTGGRPEVQRGELREILLGSLPAGTVRWGRKVTGVRPLGGGRHEVAFADGATVTTALLVGADGAWSRVRPLLSEATPEYTGTSFVETYLFDADAQHPATAKAIGGGSMLALAPGKGIQAHRESGGTLHTYVALRRSQGWFADVDFTAPAEAAARIAREFDGWTPELTALITDGDTAPILRPLYALPTGHRWDRVPGVTLLGDAAHLAAPNGEGANLAMLDGAELATALAAHPGDAEAALTAYEQAMFTRGTEAADADRIQELMFGDDAPHGLVAEFAGDR
>NC_016113.1|WP_014151245.1|876701_877289_-|TetR/AcrR-family-transcriptional-regulator
MAERKARSDAERNRQAVIAAADELFARGGGPRGVSMDDVAAAAGVGKGTLFRGFGDRTGLILAVVEARIEPLRQAVENGPPPLGPDTPPRERVPAVLDAILRFKFDNRQLSLALEEAGRGSPYQAGHYAWWHRTLRDALRRLPDATDADSDFTAHALLAAVRADLVEHLAAKLTLNQVAARLAEFTARLLDAPRR
>NC_016113.1|WP_014151244.1|875980_876640_-|GNAT-family-N-acetyltransferase
MPLPTSAVRGRALVVERIRSRAVPEEITLRPVTAGDLDLFEREFSGPEGTGEYQWFGFGSPAGLRRQFAENGLLGPDGGVLAVAEAGRTVGRVEWFAGTWGRPATSTCWTLGIGLVPAVRGRGIGTLAQRLLAGYLFDHTRAERLQAWTDFANLAEQRALEKAGFVREGVLRSAQWRGGRWHDQVIFSMLRAERPGGRPARARDGTGPAPPIRRPRHGS
>NC_016113.1|WP_014151242.1|875069_875762_-|demethylmenaquinone-methyltransferase
MLEAFADVTTPLLADACVRLGVPLRAAPPGIAAVVRGRRVAGRALPVRHYGSVDVFLEAFGAARPGDVLVIDNRGRTDEACIGDLAVLEARAAGVAGVVVWGLYRDTPELVEIGLPVFGYGSYPPGPARVLPREPEALVSARFGEHTVTGDDVVFGDDDGVLFVPGDRAGEVLATAERIARTERDQAARIRAGETLRRQTAFDDYLARRAADPSYTFRQHLRRVGGAIEE
>NC_016113.1|WP_014151241.1|874023_874947_+|helix-turn-helix-domain-containing-protein
MNVEPDVTPEPFGQAGAPLDRRAELSEFLRTRRARLKPEDVGLPGSSRHRRVPGLRREELAQLAGISVAYYTRLEQGNGRNVSAEVLDAIARALRLSGAERAHLFHLTNPAQHRKKTPARPQQVRPALRQLLDSLEGVPAYVMGRRADVLAWNRMASAVFGDWGALPPRDRNWARLVFLRPGFRDIFLEWETKAYDVVSFLRMDAGCHPDDPQLSALVGELSVKSEDFRRLWATHDVKEKGHGVKRLRHPLVGDLTLSFETFRLPDDPDQALILYHAEPGSPSAESLRLLASWGEDATRAGTTSQRL
>NC_016113.1|WP_014151240.1|872798_873839_-|NAD(P)-dependent-alcohol-dehydrogenase
MTTAAAYAAPSAKAPLERTTVERRPVGEYDVRIDIKYAGICHSDIHQAHDGWGGSQFPMVPGHEIAGVVAEVGAKVTKYAVGDRVGVGCFVDSCRECEYCLQGLEQYCVEGNTQTYNDRDRNGEPTYGGYSSHIVVDENYVLRIPDGLSLDVAAPLLCAGITTYSPLKHWNAGPGKKVAVIGLGGLGHMAVKIAHALGAEVTVLSQSLRKKDDGLRLGADHYYATSDPKTFEELAGTFDLILSTVSAPLDFGGYLALLKTDGALVNVGAPEEPVSLNLFSLIGGRKTLAGSLIGGIAETQEMLDFCAEHGLGAEIELISADRINEAYERVLASDVRYRFVIDTSTI
>NC_016113.1|WP_014151239.1|871783_872725_+|SGNH/GDSL-hydrolase-family-protein
MPTAAADSTRTARTGRTGRRRKAAAALVGAALLAGALTGVPAPAQAAEASGTAFVTGRYVALGDSYAAGAGIPALTAGMCLRSDHDYGTLVAGGLRSPAYTDVTCAGAKVAALTSAQTDGGAVVNGPQLAAVAPDATLVSLTVGGNDLGTSDLGFADVVAACSALAVTDPLGTPCQDAYGDTLTRRVDAAAPRLADALRLIHLQAPRATVVVAGYPAVLPAEPSSCLGKLPVTGGDLRYLRSVLDRLDTMVAQTAGAGGAVYADTMAATTGHDTCSADPWIEGLLPASPALPLHPDATGERAMADAVLHALGR
>NC_016113.1|WP_014151238.1|870398_871604_-|helix-turn-helix-domain-containing-protein
MTRAPAPPAEIAPVAAALLDRAAELGCRMARRIRAEVAHYRGEERVPFGELTASCRRNTELVLGRLADGDALGGLGQAEETGRRRARQGAPLAELLHAYRIGSEFLWSELAAAARTAEGVTADTIVALGAWWVNEGLAAAAGDAYRQAAVERLLRRETERSVLVEALFTGMLTDPTTLWETAGVLGLPATGPFVVVAAEVPAPGREALPGVESRLRAEGLRSAWRLLPGLHAGVVALAEPDGDQAVLAALGRFPQARSGVSPAYRSLTGTPRALRLARLALAGLTPDRAPGVARFDDSPVALLVAAAPDEARRIARTVLERVTRLPAAERDRLLETLEHWYAAAGSVAEAARSLYCHRNTVRYRLRRPEELTGRSLRDPRAVADLAVALRALRLPSAAPDR
>NC_016113.1|WP_014151237.1|869740_870382_+|hypothetical-protein
MDGALARILDAAARGEFPPPDGGVTVVPQPAPRDAGVIAFTAHSVVFTDEDPHWVRATVAALDCDPLAATMNPRFLTALLDRTGRANDTVDLLTVASALPGEPPLALREIEDPGHPRVARALTRRDEVRVWTADGGVVVLGRGVAGRWETSVEVDEPERHRGLGRALATAARHLIPAGDVVWAQQATGNARSVRSFQAAGYRPVGAEALFLPR
>NC_016113.1|WP_014151248.1|880300_880867_-|GNAT-family-N-acetyltransferase
MTHVREMTEADVDAVSAIRVGGWRHAYAGIVPASYLAAMSVEEDALRRRALLRRPDRPGTDLVAVGADGTVTGWACVGSYRGGPPGPDAGELYALYVRPDLMGTGIGRTLLATAESRAADQGHGTLLLWVLADNTRARHFYETAGYTADGAVQHDDYGPTELPELRYHRPLHPAPAAPATGAVNPGNG
>NC_016113.1|WP_014626931.1|881102_882218_+|hypothetical-protein
MWPRRGVLTAAGALAAGAVTGGGRARAAVRGLTGTAVLSPRQRAGQRVVYSYPGPTPPASLLRAISAGECAGVVFFGENISDEAQIASVIGQLRQANAAGPVGAPLLLMTDQEGGEVRRLPGAPVPSEKRIGQSADPAGQAANAGTGAGRNLAGVGMNVNLAPVLDVFREPGDFIDEYQRSYSDDPAVVAECAAAFVTAQQATGVAATAKHFPGLGAATRAQDTDTGPVTLTLSRSELRTVDEAPYAAAIGAQVRLVMVSWAVYPALDPRWPAGLSSTVVQGELRGRLGFTGVTVTDALEAGALPGGYDTGRRAVLAADAGMDLLLCSARDTGQCDAAVTALAAAYTGGRLDPVAFDAAVQRVGALRAALS
>NC_016113.1|WP_014151250.1|882232_882442_-|ferredoxin
MRPLELAVDRERCCGAGMCALTAPEIFDQDPEDGLVVLVTPRPPARLRGAAREAAALCPAGAVTVREPG
>NC_016113.1|WP_014151251.1|882438_883665_-|cytochrome-P450
MTSCPVDHAAQSEPVTLPLERPAGCPFDPPAELGRLREQHPLTPMTYPDGHVGWLATGHAVIRAILADPRFSSRYEILHYPFPGGPTSELPPAPVGDLTGLDAPEHTRYRRLLTGKFTVRRMRLLTERVEEIVTEHLDAMERSGGPLDLVAAYAQPVPALMICELLGVPYSDRDLFQRHVATVNDQNATMADQGAAITAIHEYVHTLVVAKRARPTDDLLGDLTRETELSDGELAGIGTFLLGAGLDTTANMLSLGAFALLSDPAQLAALRAEPELADPAVEELMRYLSIAHTGARTALEDVELAGRLIKAGDTVTLSVQAANRDPERFPDPDTLDLRRKATGHLGFGHGIHQCLGQQLARVEMRVAIPALFRRFPTLRLAVPAEEVPLRTDSSIYGVHRLPVTWERG
>NC_016113.1|WP_014151252.1|883817_884345_-|hypothetical-protein
MDLTPYVDNLRHEIAVAADSGGEEARALAERLAAPLESSARLTLLSALSAAMAEVTRDLAPGSVEVRLRGLDPEFVVVPPPPPEAYEADWGYDSASAHTAPPPPPADGDEGGTARINFRLPAHLKARVEDAAGREGLSVNAWLVRAASAALEPGGGRPAGRARRHGGQGYTGWVR
>NC_016113.1|WP_014151253.1|884631_885852_+|cytochrome-P450
MVDRTDPAAPPGMPRVRRCPYDPAPEYARLREEAPVSRISFPGGGTGWLVTRYQDVRAMLADPRFSSRQGTTAPQVRPVPAALPEPPPGALLRLDEPEHRTYRRPVMRAFTVKQVTRLRPRIQRITDDHLDAMERDGGPVDLVAALALPVTSLVICELLGVSYADRGAFQGLAGRLLAVDISPEQSAQDRAALAAFMTDLVAAKRRDPGDDLISALIAEADADPDSPLTDHALTILGALLLIAGHETTANMISLGALTLLDHPDQLAAWRARPELADRAVEELLRYLTIIQFGLARVATEEVTLGGRTIRAGEMVVAALPSANRDPLMGLADPDRLDITRSPAPHLAFGFGPHQCLGQQLARAELQITLGSLFARFPTLRTAVPTAELPFRDDMIIYGLHALPVTW
>NC_016113.1|WP_014151255.1|886597_886966_-|hypothetical-protein
MLDEAFTALAAAGGTAVVTAVGTDTWGGMRQAVARWFGRGDTVRERAEAERLEQTAALLRATEGTAGAEQERTRQSAWWQSRIESALEELDEAERAWAAVRLRAVLTEHARPDGTATRPRSA
>NC_016113.1|WP_014151256.1|887089_887473_-|winged-helix-turn-helix-transcriptional-regulator
MGHGAAATASNAVPRARLDAADAAKVATTLQALATPSRLLILARLREGPLPATELAAEVGMEQSACSHQLRLLRNLGLVTGTRQGRSVVYALYDNHVAELLDQALYHVEHLRLGLTDGPVDEDAAAG
>NC_016113.1|WP_014151257.1|887581_889558_+|heavy-metal-translocating-P-type-ATPase
MSSTLTRPAPRAGGDPAAPPPARRTRILALPEARWAALALAFFLIALAAQALGAPAWACGTLYALVYAAGGWEPGWAGLTALRQKTLDVDLLMVVAALGAAAIGQVLDGALLIVIFATSGALEALATARTADSVRGLLDLAPATATRITDDGAEETVPSAELAVGDVVLVRPGERIGADGRVLDGASEVDQATITGEPLPVAKSAGDEVFAGTLNGTGALRVKVERDPADSVIARIVAMVEEASGTLAPTQLFIEKVEQRYSIGMVAATLALFAVPLCFGAALQPTLLRAMTFMIVASPCAVVLATMPPLLSAIANAGRHGVLVKSAVVMERLGQVDQVALDKTGTLTEGTPQVTDVRPVPGAGLTEDELLTVAAAAEHPSEHPLARAVVAAAAARGLRPPPVTDFASAPGTGVTATVDGRRVAVGSPTRLPAAADGPATVVAEELAGKGRTVVVVEVDGVPSGVLGIADRLRDQAPEAVAALTALTGHPPVLVTGDHAGAAVPLGRRTGITDIRAGLLPEQKVAVVRELERAGRRVLVVGDGVNDAPALAAAHTGVAMGRAGSDLALQTADAVVVRDELATVPAVVALSRRARSLVTQNLVVAAVFITGLVVWDLVGTLPLPLGVAGHEGSTVIVGLNGLRLLADSAWRRAATGRAS
>NC_016113.1|WP_014151258.1|889554_889962_+|hypothetical-protein
MSRRDRGEARAAGPARCTVTVCRGCCCGTGKVPGVDHAAQLAELRRALSGTATVRPVTCLDACEHANVIVVQPSAAGRAAGGRPVWLGLVNDPDAVGDITAWVEAGGPGLADPAGILDLYAFSPSRRIRRDAELS

Crispr_ID: NC_016113_2

• CRISPR_ID: NC_016113_2
• CRISPR_location: 898045-898313
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 4 spacers
• Cas_protein_info: csa3

Consensus repeat of NC_016113_2

Consensus_repeat	Method
TCGTCCCCGCGAGCGCGGGGGTGTTCC	CRT

spacers of NC_016113_2

>2.1|898072|34|NC_016113|CRT
TTTGCGCCAGGTCCGCAGACTGCGGGTTTTGGCA
>2.2|898133|34|NC_016113|CRT
TCTCCGCGGCGGAGCGCAGGTGGTCCTCCGCCTA
>2.3|898194|34|NC_016113|CRT
GGTACACGGGGCTACGGACGACTACCGGCAGGCG
>2.4|898255|32|NC_016113|CRT
TGGACGGCCGGGGCGATCGGCGTCGCCGCGCT

CRISPR arrays and Neighbor proteins around NC_016113_2

CRISPR arrays

The CRISPR arrays of NC_016113_2

>merge|NC_016113|2|898045-898313|CRT
TCGTCCCCGCGAGCGCGGGGGTGTTCCTTTGCGCCAGGTCCGCAGACTGCGGGTTTTGGCATCGTCCCCGCGAGCGCGGGGGTGTTCCTCTCCGCGGCGGAGCGCAGGTGGTCCTCCGCCTATCGTCCCCGCGAGCGCGGGGGTGTTCCGGTACACGGGGCTACGGACGACTACCGGCAGGCGTCGTCCCTGCGAGCGCGGGGTGTTCCGTGGACGGCCGGGGCGATCGGCGTCGCCGCGCTGTCGTCCCGCGAGCGCGGGGGTGTTCC

>NC_016113|2|1|898045-898313|CRT
TCGTCCCCGCGAGCGCGGGGGTGTTCC	TTTGCGCCAGGTCCGCAGACTGCGGGTTTTGGCA
TCGTCCCCGCGAGCGCGGGGGTGTTCC	TCTCCGCGGCGGAGCGCAGGTGGTCCTCCGCCTA
TCGTCCCCGCGAGCGCGGGGGTGTTCC	GGTACACGGGGCTACGGACGACTACCGGCAGGCG
TCGTCCCTGCGAGCGCGGGGTGTTCCG	TGGACGGCCGGGGCGATCGGCGTCGCCGCGCT
GTCGTCCCGCGAGCGCGGGGGTGTTCC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016113.1|WP_014151276.1|905489_906581_+|zinc-binding-alcohol-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|223677
NC_016113.1|WP_014151264.1|895026_895566_-|hypothetical-protein	unknown	unknown	unknown
NC_016113.1|WP_014151275.1|904670_905300_+|LysE-family-translocator	unknown	unknown	gnl|CDD|224199
NC_016113.1|WP_014151273.1|902484_903264_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|180604
NC_016113.1|WP_014151272.1|901578_902469_+|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|375319
NC_016113.1|WP_014151270.1|899763_900378_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|366102
NC_016113.1|WP_014151269.1|899242_899542_+|hypothetical-protein	unknown	unknown	unknown
NC_016113.1|WP_014151258.1|889554_889962_+|hypothetical-protein	unknown	unknown	unknown
NC_016113.1|WP_014151257.1|887581_889558_+|heavy-metal-translocating-P-type-ATPase	unknown	unknown	gnl|CDD|319849
NC_016113.1|WP_014151271.1|900387_901296_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|197775
NC_016113.1|WP_014151260.1|890437_891376_+|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|366166
NC_016113.1|WP_014151277.1|906898_907717_+|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl|CDD|119339
NC_016113.1|WP_014151268.1|898516_898957_-|hypothetical-protein	unknown	unknown	gnl|CDD|380387
NC_016113.1|WP_106433081.1|897082_897598_+|ATP-binding-protein	unknown	unknown	gnl|CDD|340413
NC_016113.1|WP_014151263.1|894295_894940_+|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	unknown	unknown	gnl|CDD|274422
NC_016113.1|WP_014151259.1|889969_890218_-|hypothetical-protein	unknown	unknown	unknown
NC_016113.1|WP_041823648.1|891436_892705_-|cytochrome-P450	unknown	unknown	gnl|CDD|225035
NC_016113.1|WP_014151262.1|892950_894213_+|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl|CDD|238868
NC_016113.1|WP_014151274.1|903394_904477_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|366102
NC_016113.1|WP_014151256.1|887089_887473_-|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl|CDD|238042

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_016113.1|WP_014151256.1|887089_887473_-|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	6.7e-18	59.9	0.3

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016113.1|WP_014151276.1|905489_906581_+|zinc-binding-alcohol-dehydrogenase-family-protein	gnl|CDD|223677	COG0604, Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only].	8.27513e-57
NC_016113.1|WP_014151275.1|904670_905300_+|LysE-family-translocator	gnl|CDD|224199	COG1280, RhtB, Putative threonine efflux protein [Amino acid transport and metabolism].	1.93381e-36
NC_016113.1|WP_014151273.1|902484_903264_-|SDR-family-oxidoreductase	gnl|CDD|180604	PRK06523, PRK06523, short chain dehydrogenase; Provisional.	1.13177e-72
NC_016113.1|WP_014151272.1|901578_902469_+|helix-turn-helix-transcriptional-regulator	gnl|CDD|375319	pfam17765, MLTR_LBD, MmyB-like transcription regulator ligand binding domain. This domain is found in a family of actinobacterial transcription factors. The structure shows it has a PAS domain like fold and it is bound to Myristic acid.	1.8629e-07
NC_016113.1|WP_014151256.1|887089_887473_-|winged-helix-turn-helix-transcriptional-regulator	gnl|CDD|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	6.64344e-18
NC_016113.1|WP_014151257.1|887581_889558_+|heavy-metal-translocating-P-type-ATPase	gnl|CDD|319849	cd07551, P-type_ATPase_HM_ZosA_PfeT-like, P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which transports copper, and perhaps zinc under oxidative stress, and perhaps ferrous iron. Bacillus subtilis ZosA/PfeT (previously known as YkvW) transports copper, it may also transport zinc under oxidative stress and may also be involved in ferrous iron efflux. ZosA/PfeT is expressed under the regulation of the peroxide-sensing repressor PerR. It is involved in competence development. Disruption of the zosA/pfeT gene results in low transformability. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NC_016113.1|WP_014151260.1|890437_891376_+|alpha/beta-fold-hydrolase	gnl|CDD|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	7.55385e-19
NC_016113.1|WP_014151277.1|906898_907717_+|enoyl-CoA-hydratase/isomerase-family-protein	gnl|CDD|119339	cd06558, crotonase-like, Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.	8.5613e-47
NC_016113.1|WP_014151268.1|898516_898957_-|hypothetical-protein	gnl|CDD|380387	cd06982, cupin_BauB-like, Pseudomonas aeruginosa BauB and related proteins, cupin domain. This family includes bacterial proteins homologous to beta-alanine degradation protein BauB from Pseudomonas aeruginosa, which is involved in the degradation of beta-alanine. Also included are Rhodopseudomonas palustris Rpa4178 and Bordetella pertussis Bp2299, which are both proteins with unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	3.64261e-08
NC_016113.1|WP_106433081.1|897082_897598_+|ATP-binding-protein	gnl|CDD|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	3.86086e-16
NC_016113.1|WP_014151270.1|899763_900378_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	5.7826e-13
NC_016113.1|WP_014151263.1|894295_894940_+|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	gnl|CDD|274422	TIGR03083, TIGR03083, uncharacterized Actinobacterial protein TIGR03083. This protein family pulls together several groups of proteins, each very different from the others. They share in common three conserved regions. The first is a region of about 38 amino acids, nearly always at the N-terminus of a protein. This region has a bulky hydrophobic residue, usually Trp, at position 29, and a His residue at position 37 that is invariant, so far, in over 150 instances. The second conserved region has a motif [DE]xxxHxxD. The third conserved region contains a hydrophobic patch and a well-conserved Arg residue. Most examples are found in the Actinobacteria, including the genera Mycobacterium, Corynebacterium, Streptomyces, Nocardia, Frankia, etc. The pattern of near-invariant residues against a backdrop of extreme sequence divergence suggests enzymatic activity and conservation of active site residues.	3.50229e-17
NC_016113.1|WP_041823648.1|891436_892705_-|cytochrome-P450	gnl|CDD|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	2.59634e-75
NC_016113.1|WP_014151262.1|892950_894213_+|SGNH/GDSL-hydrolase-family-protein	gnl|CDD|238868	cd01830, XynE_like, SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.	8.52117e-87
NC_016113.1|WP_014151274.1|903394_904477_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	4.82506e-12
NC_016113.1|WP_014151271.1|900387_901296_-|helix-turn-helix-domain-containing-protein	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	2.42221e-09

Protein sequences

>NC_016113.1|WP_106433081.1|897082_897598_+|ATP-binding-protein
MEPFLAIAPPDRCFDLTIERHSSNAELDQHDRRRPGVIRRICRAKLRHWGTCDDLTNDVLLASTELVTNALKHSYGARIRVSLSCWPGAVRIDVDDGAPSPPACPRSAGLLDEDGRGLAIVAALADAWGRSGSTTWCLLTADASEQPHGNLPLPPSGHLANPTTIRPASQE
>NC_016113.1|WP_014151264.1|895026_895566_-|hypothetical-protein
MKTAGIEIRHFPDVEPVWDTLIGIYAEVRADRLHDPHYSVERFGERLARHASEPGWEAAVGYDGDEPIGYAYANTIEQGDRWWKRVQCPVPDAVLCAPTLALKEIMVRVGWRKTGASRRIHDDLLAQRTEPQVSLMVNPQAGDGKVHALYETWGYTDVGPSRPSLDSPVLMVMVRERAM
>NC_016113.1|WP_014151263.1|894295_894940_+|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme
MAHTTDHVKALIAAERRELAAVLHALRPEQWEAPSLCTGWRVREVAAHMSTGFRHPTRKVLWELVKSAGRVNAMADRLARADATALTPGELADAMADNAHHPWKPPVGGYENALGHDVVHGLDITTALGLDRRIPEERLRVLLAGVTRTSARFFGAPLHGIRLQADDLDWTFGTGTPVTGNAQDLLLAAFGRKLPPGRLSGPGGGRFVRVPGVG
>NC_016113.1|WP_014151262.1|892950_894213_+|SGNH/GDSL-hydrolase-family-protein
MPAKSVGAAAALVLTAALAVAGARAAQSPPAPVWNAAWSAAPQRPSTGFTPNWSEAGFSGQTLRQVVRVTTGGSRLRIRLSNAYGTSPLHIAGATVARRDHGARLRAGTVRQLTFGGSRAATVPAYGQLTSDPAGLPLRAFEPVTVTLHLDGTTGPATFHAQSMATSYAADGDHTADVADTAFRRTTQSWYYLSGVDVSGGDRPVRPGRTGGIVLFGDSITDGFKSTPDRDHRWSDALAERLATTGRPRPVLNAGIGGNLVLNDSAWYGQRSSARFTRDALDLPGVRTVVILEGVDDIGYSETDKPTYKPAPVVTAAQLIDGHRELIRQARARGIRVVGATLLPFGGSDHYGTRAAAVSLAFDQWVRTSGEYDAYVDFAKALADPHHPERLDPRYDSGDHLHPNDAGYRAMARAMDLSAL
>NC_016113.1|WP_041823648.1|891436_892705_-|cytochrome-P450
MMKIRTRIGAWLGRRYMANLRKKGFDLSKALPESTLMPLRRDGLDPVPDLGAMRRKAPVTKLKVPLGVNVWLVTGYEEAKAVLGDAGSFSNDFTNLIGTGVTSGTSPGGLGFADPPDHTRLRRLLTPEFTMRRLSRLTPRIHTIVEERLAEMAAATGPVDLVEAFAMPIPSLVICELLGVPYEDREEFQRLGTSRFDVFSGADASFGAISESLSYLRDIVKKERENPGDGLLGMLVREHGDAIDDEELAGLADGVLTGGLETTASMLALGTLLMLQDRQHFTALLADDAAIDPFVDELLRYLTVVQVAFPRFARRDLEIGGQAIGSGDIVLCSLSGADRDEHLGPHMEEFDPTRPAAGSHLAFGHGIHRCIGAELAKMELRAAYPALVRRFPEMTLAVPAEELRFRKYSVVFGMESLPVNLG
>NC_016113.1|WP_014151260.1|890437_891376_+|alpha/beta-fold-hydrolase
MSRSDTNVPPSVPWSSARDYAELNVPVRGGELTVLRRAAREPGAPVVLALHGITANALAWSRVADHLAGRVTVVAPDLRGRAGSRALPGPYGIGAHAEDVAAVAEALGLESAVLAGHSMGAFVAALTAVRHPGRFASVVLVDGGLAFPAPAGLGTDELLEAVIGPAMRRLRMTFPDRDAYRDYWRVHPAFGGRWSPWTDAYLQRDLTGAEPELTSSCVLDAVREDGAGVFGDPRVRSAIRELPHPARLLWAERGLLDEPQGLYDEERLATAALEPDRVATHRIPDTNHYTVLGGDAGARAVAGHLLDAAGLR
>NC_016113.1|WP_014151259.1|889969_890218_-|hypothetical-protein
MSDRRSPSARTGSPSAPKRRRAGVTIAAVVVLGTVVGTGLPGRVDAGLSAPAHAAAPRDAVRRGVTALVPAVLAAVRGGHSS
>NC_016113.1|WP_014151258.1|889554_889962_+|hypothetical-protein
MSRRDRGEARAAGPARCTVTVCRGCCCGTGKVPGVDHAAQLAELRRALSGTATVRPVTCLDACEHANVIVVQPSAAGRAAGGRPVWLGLVNDPDAVGDITAWVEAGGPGLADPAGILDLYAFSPSRRIRRDAELS
>NC_016113.1|WP_014151257.1|887581_889558_+|heavy-metal-translocating-P-type-ATPase
MSSTLTRPAPRAGGDPAAPPPARRTRILALPEARWAALALAFFLIALAAQALGAPAWACGTLYALVYAAGGWEPGWAGLTALRQKTLDVDLLMVVAALGAAAIGQVLDGALLIVIFATSGALEALATARTADSVRGLLDLAPATATRITDDGAEETVPSAELAVGDVVLVRPGERIGADGRVLDGASEVDQATITGEPLPVAKSAGDEVFAGTLNGTGALRVKVERDPADSVIARIVAMVEEASGTLAPTQLFIEKVEQRYSIGMVAATLALFAVPLCFGAALQPTLLRAMTFMIVASPCAVVLATMPPLLSAIANAGRHGVLVKSAVVMERLGQVDQVALDKTGTLTEGTPQVTDVRPVPGAGLTEDELLTVAAAAEHPSEHPLARAVVAAAAARGLRPPPVTDFASAPGTGVTATVDGRRVAVGSPTRLPAAADGPATVVAEELAGKGRTVVVVEVDGVPSGVLGIADRLRDQAPEAVAALTALTGHPPVLVTGDHAGAAVPLGRRTGITDIRAGLLPEQKVAVVRELERAGRRVLVVGDGVNDAPALAAAHTGVAMGRAGSDLALQTADAVVVRDELATVPAVVALSRRARSLVTQNLVVAAVFITGLVVWDLVGTLPLPLGVAGHEGSTVIVGLNGLRLLADSAWRRAATGRAS
>NC_016113.1|WP_014151256.1|887089_887473_-|winged-helix-turn-helix-transcriptional-regulator
MGHGAAATASNAVPRARLDAADAAKVATTLQALATPSRLLILARLREGPLPATELAAEVGMEQSACSHQLRLLRNLGLVTGTRQGRSVVYALYDNHVAELLDQALYHVEHLRLGLTDGPVDEDAAAG
>NC_016113.1|WP_014151268.1|898516_898957_-|hypothetical-protein
MTDHTYLSDLPLAGDLVATGYEGWSPELRAEFEAHAHDGHVGSRLLSENARVRVWEIRLAPGDRWHAHRHVLDYFWTAITPGRSRQHTHDGTTRDVSYHAGETRHFTFGPGEFLLHDIENTGETELIFTTVEHLDSANAPLRLELR
>NC_016113.1|WP_014151269.1|899242_899542_+|hypothetical-protein
MHLLARLLAGTALAACVTVVVVPAWTAPGAPAASGARCGGLSGPRRGVGYDNCAAHAVRIRVGHYVGVGDDYVCVPAFGRYRAPGWNTRVVERIADECR
>NC_016113.1|WP_014151270.1|899763_900378_+|TetR/AcrR-family-transcriptional-regulator
MAQQERALKTRLLIVEAAGAVFDELGYDAATTTEIIARSGVTRGALYFHFPSKEAIADAVIASQDQFLVPPDHRVRLQATIDLTMSYARRLQHDSLLRGAVRLAVEQASYRKPDATPYVSSHEVVCRLLREAEANGELLPTADPEELTPLIVGAFTGIQVLSQAHNNRLDLLERVSALWKNLLPAIAVAGLLPHLDTSPEARPR
>NC_016113.1|WP_014151271.1|900387_901296_-|helix-turn-helix-domain-containing-protein
MIPRSFPALGDRGGGARHRPADRRPDRAAPPGGPSAGHPLPAFLRARRLRSGLSQEGLAWRLDVSTRTVSNWERGQHGVDPRRVADLAAALALTREEERELAGLAGSRTPAARPAPAPETPHPGDPAGFAREWHRGFRDVGMPAYLRDPAWRLLACNAAYTRLFSGVARVPEAIPRENLARFICLHPDAPRLLADWYEGWLVPLLCEISDDLRAAPPRSPLYALLKAVLARPEIARAWRTEVPARAAARIRSAAAPEPAAPRHIVHPDPAVGRAAVHVSSMVPQGLDGHRSVFWRLQSLEAP
>NC_016113.1|WP_014151272.1|901578_902469_+|helix-turn-helix-transcriptional-regulator
MTDAQPSGPVVEHGRGDLTAEERRQKLSFLREKRDSVDRSSFEARYPVEVPRRLPGRGRHAPGLTLVEMGRLLGLRDGSWYADLERGQVDNAPVDRLFKVAELLDLTPRQYEFLCVYACRPKPGYPAAGLPGGYREVLDLYQGPAYFQDAGWNLLRPKMYNAAAEALFNGIPDDFNFIRWVLLERSVRRPPEGGRRHAWLPDFWQVWAPRALPVVRAAYVARPDNATLARLHADLAADPEIGPIYQGRLPPYPHTDGDLRPFVHGSTGERGMVRINVLTPRGSDDTLMLLNWHPGA
>NC_016113.1|WP_014151273.1|902484_903264_-|SDR-family-oxidoreductase
MDLRMSGKTAVVTGASRGIGLAVVRTLTGEGVRVVGAARTVTAELKDAGAVPVAVDLSTPEGCAELVQRALAELGGIDLLVNNAGGGDHFTAAGFLTADDEIWERSWALNFFAPVRLIRAALPSLIERRGAIVNVSSIGARNATGPIDYATAKAALNTLGKALAAEFGPRGVRVNTVSPGPTRTPVWEDPDGYGAQQAALGGQELADYVARVPARSGQLTGRLVEPGEVADLIAFLGSDLAASVHGADYVIDGGALKTV
>NC_016113.1|WP_014151274.1|903394_904477_-|TetR/AcrR-family-transcriptional-regulator
MARLTRAETQERNRDKVLDAAREEFAERGYRDARIDAIAERAGLTRGAVYSNFPGKRALYFAVLAALAERVPEGPPPRPVRSGGDALAAFARAWVSRLPPAGDDGPGPARLAMDLMPEVITDAATRRPFAQLLKLDAILLGLALERLEPAGRPARRMVRVAEAVLTALHGTAQLAAAAPGFLDPLDAVRVCERLAGLPLDDDPPPAPGLPPVHHVDEPWSPPPATDAVTGDPLPADGEPDQVVTVLGLHRLEAAEDAVRAAPPDTPVTAVLVTADPGELGALARLSVAELCGCLRQAFPASARPPLRVVHDPSGAFAAAAGVPAVDDRTETAIRLASARVTARAQGPGAARAVAATPRRG
>NC_016113.1|WP_014151275.1|904670_905300_+|LysE-family-translocator
MLTTALAFLGACVLIAAAPGPSTMLIIRQSLHSRRAGFLTVLGNETGVLTWGVVAALGLTALLAASRTAYDVMRIGGAVVLVWYGVQTLRAARRGEARPSAADDEAAVVPRSGWKIYRSGLLLNLANPKAAVFAMSFLPQFVPAGAPKLPVITALAAFQALFEVGYYGMYVWFVGRMKRVISRAGVRRRLEQVSGGVLVLLGIRMAVES
>NC_016113.1|WP_014151276.1|905489_906581_+|zinc-binding-alcohol-dehydrogenase-family-protein
MTLPTETWAVRIHRHGGPEVLVHERLPLPPLGPADVLVAVDTASVSGWDVKYRRGLPPGARLPGRERYRLPLQLGREAAGTVLATGPEAAGRFRPGDRVVAVVHPENPRAPETVRGLGNLSTGIALPGHQAPGGYARYLICHQDMWLPLPSGVDLEQAAVTLWPYATCHRVLRDRLRVALGETLLVCGATGAMGLAALRLARLTGVRVIAMTRYRAKERALRTAGADEVVVAGDPRQACEAVRALTGGEGVDHAVDFTGSAALLRLAVDSLRLGGRLCPAATQRPPGPLPVTTGDLTRLEITVYGIRGARHRDALRVLALLGDGSLPATPIAARFPLSRAGAAHEFLEHNTTAVGRVVLKPGW
>NC_016113.1|WP_014151277.1|906898_907717_+|enoyl-CoA-hydratase/isomerase-family-protein
MKQESRQDRFEDQDEDRFAAQESIECSRLGDGIALAEFSGAHEQNPFSRARMRELTALMRELDADEKVRCVVLYGGAGRSFGVGGDFHEVSEFTGGDEVNAWIDDITDLYTTVAAISKPVIAAIDGYAIGVGLQISLCCDYRLGSEQARLVMPEFRVGIACNFGGFMLEAAAGRTVMQRMLLTCDEWPAERALADGLLHETVASPRLLDRALELARTISGYTAEAVQSTRPRVNAPFVAGLERIRREAKESHRRAFAAGEAQVRMRRVIGRS

Crispr_ID: NC_016113_3

• CRISPR_ID: NC_016113_3
• CRISPR_location: 898987-899095
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_016113_3

Consensus_repeat	Method
GTCAGCGTAGCGGCGCGGGGCGCGG	CRISPRCasFinder

spacers of NC_016113_3

>3.1|899012|59|NC_016113|CRISPRCasFinder
GGCCAACGGTGCCAGTTGACCGGCGACGGAACGAGGCGATCCGCAACGGTGATGGTGTC

CRISPR arrays and Neighbor proteins around NC_016113_3

CRISPR arrays

The CRISPR arrays of NC_016113_3

>merge|NC_016113|3|898987-899095|CRISPRCasFinder
GTCAGCGTAGCGGCGCGGGGCGCGGGGCCAACGGTGCCAGTTGACCGGCGACGGAACGAGGCGATCCGCAACGGTGATGGTGTCGTCAGCGTAGCGGCGCGGGGCCGGC

>NC_016113|3|1|898987-899095|CRISPRCasFinder
GTCAGCGTAGCGGCGCGGGGCGCGG	GGCCAACGGTGCCAGTTGACCGGCGACGGAACGAGGCGATCCGCAACGGTGATGGTGTC
GTCAGCGTAGCGGCGCGGGGCCGGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016113.1|WP_014151276.1|905489_906581_+|zinc-binding-alcohol-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|223677
NC_016113.1|WP_014151264.1|895026_895566_-|hypothetical-protein	unknown	unknown	unknown
NC_016113.1|WP_014151275.1|904670_905300_+|LysE-family-translocator	unknown	unknown	gnl|CDD|224199
NC_016113.1|WP_014151273.1|902484_903264_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|180604
NC_016113.1|WP_014151272.1|901578_902469_+|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|375319
NC_016113.1|WP_014151270.1|899763_900378_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|366102
NC_016113.1|WP_014151258.1|889554_889962_+|hypothetical-protein	unknown	unknown	unknown
NC_016113.1|WP_014151257.1|887581_889558_+|heavy-metal-translocating-P-type-ATPase	unknown	unknown	gnl|CDD|319849
NC_016113.1|WP_014151271.1|900387_901296_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|197775
NC_016113.1|WP_014151260.1|890437_891376_+|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|366166
NC_016113.1|WP_014151277.1|906898_907717_+|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl|CDD|119339
NC_016113.1|WP_014151268.1|898516_898957_-|hypothetical-protein	unknown	unknown	gnl|CDD|380387
NC_016113.1|WP_106433081.1|897082_897598_+|ATP-binding-protein	unknown	unknown	gnl|CDD|340413
NC_016113.1|WP_014151263.1|894295_894940_+|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	unknown	unknown	gnl|CDD|274422
NC_016113.1|WP_014151259.1|889969_890218_-|hypothetical-protein	unknown	unknown	unknown
NC_016113.1|WP_041823648.1|891436_892705_-|cytochrome-P450	unknown	unknown	gnl|CDD|225035
NC_016113.1|WP_014151262.1|892950_894213_+|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl|CDD|238868
NC_016113.1|WP_014151274.1|903394_904477_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|366102
NC_016113.1|WP_014151278.1|907700_908684_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
NC_016113.1|WP_014151269.1|899242_899542_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016113.1|WP_014151276.1|905489_906581_+|zinc-binding-alcohol-dehydrogenase-family-protein	gnl|CDD|223677	COG0604, Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only].	8.27513e-57
NC_016113.1|WP_014151275.1|904670_905300_+|LysE-family-translocator	gnl|CDD|224199	COG1280, RhtB, Putative threonine efflux protein [Amino acid transport and metabolism].	1.93381e-36
NC_016113.1|WP_014151273.1|902484_903264_-|SDR-family-oxidoreductase	gnl|CDD|180604	PRK06523, PRK06523, short chain dehydrogenase; Provisional.	1.13177e-72
NC_016113.1|WP_014151272.1|901578_902469_+|helix-turn-helix-transcriptional-regulator	gnl|CDD|375319	pfam17765, MLTR_LBD, MmyB-like transcription regulator ligand binding domain. This domain is found in a family of actinobacterial transcription factors. The structure shows it has a PAS domain like fold and it is bound to Myristic acid.	1.8629e-07
NC_016113.1|WP_014151257.1|887581_889558_+|heavy-metal-translocating-P-type-ATPase	gnl|CDD|319849	cd07551, P-type_ATPase_HM_ZosA_PfeT-like, P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which transports copper, and perhaps zinc under oxidative stress, and perhaps ferrous iron. Bacillus subtilis ZosA/PfeT (previously known as YkvW) transports copper, it may also transport zinc under oxidative stress and may also be involved in ferrous iron efflux. ZosA/PfeT is expressed under the regulation of the peroxide-sensing repressor PerR. It is involved in competence development. Disruption of the zosA/pfeT gene results in low transformability. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NC_016113.1|WP_014151260.1|890437_891376_+|alpha/beta-fold-hydrolase	gnl|CDD|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	7.55385e-19
NC_016113.1|WP_014151277.1|906898_907717_+|enoyl-CoA-hydratase/isomerase-family-protein	gnl|CDD|119339	cd06558, crotonase-like, Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.	8.5613e-47
NC_016113.1|WP_014151268.1|898516_898957_-|hypothetical-protein	gnl|CDD|380387	cd06982, cupin_BauB-like, Pseudomonas aeruginosa BauB and related proteins, cupin domain. This family includes bacterial proteins homologous to beta-alanine degradation protein BauB from Pseudomonas aeruginosa, which is involved in the degradation of beta-alanine. Also included are Rhodopseudomonas palustris Rpa4178 and Bordetella pertussis Bp2299, which are both proteins with unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	3.64261e-08
NC_016113.1|WP_106433081.1|897082_897598_+|ATP-binding-protein	gnl|CDD|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	3.86086e-16
NC_016113.1|WP_014151270.1|899763_900378_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	5.7826e-13
NC_016113.1|WP_014151263.1|894295_894940_+|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	gnl|CDD|274422	TIGR03083, TIGR03083, uncharacterized Actinobacterial protein TIGR03083. This protein family pulls together several groups of proteins, each very different from the others. They share in common three conserved regions. The first is a region of about 38 amino acids, nearly always at the N-terminus of a protein. This region has a bulky hydrophobic residue, usually Trp, at position 29, and a His residue at position 37 that is invariant, so far, in over 150 instances. The second conserved region has a motif [DE]xxxHxxD. The third conserved region contains a hydrophobic patch and a well-conserved Arg residue. Most examples are found in the Actinobacteria, including the genera Mycobacterium, Corynebacterium, Streptomyces, Nocardia, Frankia, etc. The pattern of near-invariant residues against a backdrop of extreme sequence divergence suggests enzymatic activity and conservation of active site residues.	3.50229e-17
NC_016113.1|WP_041823648.1|891436_892705_-|cytochrome-P450	gnl|CDD|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	2.59634e-75
NC_016113.1|WP_014151262.1|892950_894213_+|SGNH/GDSL-hydrolase-family-protein	gnl|CDD|238868	cd01830, XynE_like, SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.	8.52117e-87
NC_016113.1|WP_014151274.1|903394_904477_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	4.82506e-12
NC_016113.1|WP_014151278.1|907700_908684_-|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.00857e-09
NC_016113.1|WP_014151271.1|900387_901296_-|helix-turn-helix-domain-containing-protein	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	2.42221e-09

Protein sequences

>NC_016113.1|WP_014151268.1|898516_898957_-|hypothetical-protein
MTDHTYLSDLPLAGDLVATGYEGWSPELRAEFEAHAHDGHVGSRLLSENARVRVWEIRLAPGDRWHAHRHVLDYFWTAITPGRSRQHTHDGTTRDVSYHAGETRHFTFGPGEFLLHDIENTGETELIFTTVEHLDSANAPLRLELR
>NC_016113.1|WP_106433081.1|897082_897598_+|ATP-binding-protein
MEPFLAIAPPDRCFDLTIERHSSNAELDQHDRRRPGVIRRICRAKLRHWGTCDDLTNDVLLASTELVTNALKHSYGARIRVSLSCWPGAVRIDVDDGAPSPPACPRSAGLLDEDGRGLAIVAALADAWGRSGSTTWCLLTADASEQPHGNLPLPPSGHLANPTTIRPASQE
>NC_016113.1|WP_014151264.1|895026_895566_-|hypothetical-protein
MKTAGIEIRHFPDVEPVWDTLIGIYAEVRADRLHDPHYSVERFGERLARHASEPGWEAAVGYDGDEPIGYAYANTIEQGDRWWKRVQCPVPDAVLCAPTLALKEIMVRVGWRKTGASRRIHDDLLAQRTEPQVSLMVNPQAGDGKVHALYETWGYTDVGPSRPSLDSPVLMVMVRERAM
>NC_016113.1|WP_014151263.1|894295_894940_+|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme
MAHTTDHVKALIAAERRELAAVLHALRPEQWEAPSLCTGWRVREVAAHMSTGFRHPTRKVLWELVKSAGRVNAMADRLARADATALTPGELADAMADNAHHPWKPPVGGYENALGHDVVHGLDITTALGLDRRIPEERLRVLLAGVTRTSARFFGAPLHGIRLQADDLDWTFGTGTPVTGNAQDLLLAAFGRKLPPGRLSGPGGGRFVRVPGVG
>NC_016113.1|WP_014151262.1|892950_894213_+|SGNH/GDSL-hydrolase-family-protein
MPAKSVGAAAALVLTAALAVAGARAAQSPPAPVWNAAWSAAPQRPSTGFTPNWSEAGFSGQTLRQVVRVTTGGSRLRIRLSNAYGTSPLHIAGATVARRDHGARLRAGTVRQLTFGGSRAATVPAYGQLTSDPAGLPLRAFEPVTVTLHLDGTTGPATFHAQSMATSYAADGDHTADVADTAFRRTTQSWYYLSGVDVSGGDRPVRPGRTGGIVLFGDSITDGFKSTPDRDHRWSDALAERLATTGRPRPVLNAGIGGNLVLNDSAWYGQRSSARFTRDALDLPGVRTVVILEGVDDIGYSETDKPTYKPAPVVTAAQLIDGHRELIRQARARGIRVVGATLLPFGGSDHYGTRAAAVSLAFDQWVRTSGEYDAYVDFAKALADPHHPERLDPRYDSGDHLHPNDAGYRAMARAMDLSAL
>NC_016113.1|WP_041823648.1|891436_892705_-|cytochrome-P450
MMKIRTRIGAWLGRRYMANLRKKGFDLSKALPESTLMPLRRDGLDPVPDLGAMRRKAPVTKLKVPLGVNVWLVTGYEEAKAVLGDAGSFSNDFTNLIGTGVTSGTSPGGLGFADPPDHTRLRRLLTPEFTMRRLSRLTPRIHTIVEERLAEMAAATGPVDLVEAFAMPIPSLVICELLGVPYEDREEFQRLGTSRFDVFSGADASFGAISESLSYLRDIVKKERENPGDGLLGMLVREHGDAIDDEELAGLADGVLTGGLETTASMLALGTLLMLQDRQHFTALLADDAAIDPFVDELLRYLTVVQVAFPRFARRDLEIGGQAIGSGDIVLCSLSGADRDEHLGPHMEEFDPTRPAAGSHLAFGHGIHRCIGAELAKMELRAAYPALVRRFPEMTLAVPAEELRFRKYSVVFGMESLPVNLG
>NC_016113.1|WP_014151260.1|890437_891376_+|alpha/beta-fold-hydrolase
MSRSDTNVPPSVPWSSARDYAELNVPVRGGELTVLRRAAREPGAPVVLALHGITANALAWSRVADHLAGRVTVVAPDLRGRAGSRALPGPYGIGAHAEDVAAVAEALGLESAVLAGHSMGAFVAALTAVRHPGRFASVVLVDGGLAFPAPAGLGTDELLEAVIGPAMRRLRMTFPDRDAYRDYWRVHPAFGGRWSPWTDAYLQRDLTGAEPELTSSCVLDAVREDGAGVFGDPRVRSAIRELPHPARLLWAERGLLDEPQGLYDEERLATAALEPDRVATHRIPDTNHYTVLGGDAGARAVAGHLLDAAGLR
>NC_016113.1|WP_014151259.1|889969_890218_-|hypothetical-protein
MSDRRSPSARTGSPSAPKRRRAGVTIAAVVVLGTVVGTGLPGRVDAGLSAPAHAAAPRDAVRRGVTALVPAVLAAVRGGHSS
>NC_016113.1|WP_014151258.1|889554_889962_+|hypothetical-protein
MSRRDRGEARAAGPARCTVTVCRGCCCGTGKVPGVDHAAQLAELRRALSGTATVRPVTCLDACEHANVIVVQPSAAGRAAGGRPVWLGLVNDPDAVGDITAWVEAGGPGLADPAGILDLYAFSPSRRIRRDAELS
>NC_016113.1|WP_014151257.1|887581_889558_+|heavy-metal-translocating-P-type-ATPase
MSSTLTRPAPRAGGDPAAPPPARRTRILALPEARWAALALAFFLIALAAQALGAPAWACGTLYALVYAAGGWEPGWAGLTALRQKTLDVDLLMVVAALGAAAIGQVLDGALLIVIFATSGALEALATARTADSVRGLLDLAPATATRITDDGAEETVPSAELAVGDVVLVRPGERIGADGRVLDGASEVDQATITGEPLPVAKSAGDEVFAGTLNGTGALRVKVERDPADSVIARIVAMVEEASGTLAPTQLFIEKVEQRYSIGMVAATLALFAVPLCFGAALQPTLLRAMTFMIVASPCAVVLATMPPLLSAIANAGRHGVLVKSAVVMERLGQVDQVALDKTGTLTEGTPQVTDVRPVPGAGLTEDELLTVAAAAEHPSEHPLARAVVAAAAARGLRPPPVTDFASAPGTGVTATVDGRRVAVGSPTRLPAAADGPATVVAEELAGKGRTVVVVEVDGVPSGVLGIADRLRDQAPEAVAALTALTGHPPVLVTGDHAGAAVPLGRRTGITDIRAGLLPEQKVAVVRELERAGRRVLVVGDGVNDAPALAAAHTGVAMGRAGSDLALQTADAVVVRDELATVPAVVALSRRARSLVTQNLVVAAVFITGLVVWDLVGTLPLPLGVAGHEGSTVIVGLNGLRLLADSAWRRAATGRAS
>NC_016113.1|WP_014151269.1|899242_899542_+|hypothetical-protein
MHLLARLLAGTALAACVTVVVVPAWTAPGAPAASGARCGGLSGPRRGVGYDNCAAHAVRIRVGHYVGVGDDYVCVPAFGRYRAPGWNTRVVERIADECR
>NC_016113.1|WP_014151270.1|899763_900378_+|TetR/AcrR-family-transcriptional-regulator
MAQQERALKTRLLIVEAAGAVFDELGYDAATTTEIIARSGVTRGALYFHFPSKEAIADAVIASQDQFLVPPDHRVRLQATIDLTMSYARRLQHDSLLRGAVRLAVEQASYRKPDATPYVSSHEVVCRLLREAEANGELLPTADPEELTPLIVGAFTGIQVLSQAHNNRLDLLERVSALWKNLLPAIAVAGLLPHLDTSPEARPR
>NC_016113.1|WP_014151271.1|900387_901296_-|helix-turn-helix-domain-containing-protein
MIPRSFPALGDRGGGARHRPADRRPDRAAPPGGPSAGHPLPAFLRARRLRSGLSQEGLAWRLDVSTRTVSNWERGQHGVDPRRVADLAAALALTREEERELAGLAGSRTPAARPAPAPETPHPGDPAGFAREWHRGFRDVGMPAYLRDPAWRLLACNAAYTRLFSGVARVPEAIPRENLARFICLHPDAPRLLADWYEGWLVPLLCEISDDLRAAPPRSPLYALLKAVLARPEIARAWRTEVPARAAARIRSAAAPEPAAPRHIVHPDPAVGRAAVHVSSMVPQGLDGHRSVFWRLQSLEAP
>NC_016113.1|WP_014151272.1|901578_902469_+|helix-turn-helix-transcriptional-regulator
MTDAQPSGPVVEHGRGDLTAEERRQKLSFLREKRDSVDRSSFEARYPVEVPRRLPGRGRHAPGLTLVEMGRLLGLRDGSWYADLERGQVDNAPVDRLFKVAELLDLTPRQYEFLCVYACRPKPGYPAAGLPGGYREVLDLYQGPAYFQDAGWNLLRPKMYNAAAEALFNGIPDDFNFIRWVLLERSVRRPPEGGRRHAWLPDFWQVWAPRALPVVRAAYVARPDNATLARLHADLAADPEIGPIYQGRLPPYPHTDGDLRPFVHGSTGERGMVRINVLTPRGSDDTLMLLNWHPGA
>NC_016113.1|WP_014151273.1|902484_903264_-|SDR-family-oxidoreductase
MDLRMSGKTAVVTGASRGIGLAVVRTLTGEGVRVVGAARTVTAELKDAGAVPVAVDLSTPEGCAELVQRALAELGGIDLLVNNAGGGDHFTAAGFLTADDEIWERSWALNFFAPVRLIRAALPSLIERRGAIVNVSSIGARNATGPIDYATAKAALNTLGKALAAEFGPRGVRVNTVSPGPTRTPVWEDPDGYGAQQAALGGQELADYVARVPARSGQLTGRLVEPGEVADLIAFLGSDLAASVHGADYVIDGGALKTV
>NC_016113.1|WP_014151274.1|903394_904477_-|TetR/AcrR-family-transcriptional-regulator
MARLTRAETQERNRDKVLDAAREEFAERGYRDARIDAIAERAGLTRGAVYSNFPGKRALYFAVLAALAERVPEGPPPRPVRSGGDALAAFARAWVSRLPPAGDDGPGPARLAMDLMPEVITDAATRRPFAQLLKLDAILLGLALERLEPAGRPARRMVRVAEAVLTALHGTAQLAAAAPGFLDPLDAVRVCERLAGLPLDDDPPPAPGLPPVHHVDEPWSPPPATDAVTGDPLPADGEPDQVVTVLGLHRLEAAEDAVRAAPPDTPVTAVLVTADPGELGALARLSVAELCGCLRQAFPASARPPLRVVHDPSGAFAAAAGVPAVDDRTETAIRLASARVTARAQGPGAARAVAATPRRG
>NC_016113.1|WP_014151275.1|904670_905300_+|LysE-family-translocator
MLTTALAFLGACVLIAAAPGPSTMLIIRQSLHSRRAGFLTVLGNETGVLTWGVVAALGLTALLAASRTAYDVMRIGGAVVLVWYGVQTLRAARRGEARPSAADDEAAVVPRSGWKIYRSGLLLNLANPKAAVFAMSFLPQFVPAGAPKLPVITALAAFQALFEVGYYGMYVWFVGRMKRVISRAGVRRRLEQVSGGVLVLLGIRMAVES
>NC_016113.1|WP_014151276.1|905489_906581_+|zinc-binding-alcohol-dehydrogenase-family-protein
MTLPTETWAVRIHRHGGPEVLVHERLPLPPLGPADVLVAVDTASVSGWDVKYRRGLPPGARLPGRERYRLPLQLGREAAGTVLATGPEAAGRFRPGDRVVAVVHPENPRAPETVRGLGNLSTGIALPGHQAPGGYARYLICHQDMWLPLPSGVDLEQAAVTLWPYATCHRVLRDRLRVALGETLLVCGATGAMGLAALRLARLTGVRVIAMTRYRAKERALRTAGADEVVVAGDPRQACEAVRALTGGEGVDHAVDFTGSAALLRLAVDSLRLGGRLCPAATQRPPGPLPVTTGDLTRLEITVYGIRGARHRDALRVLALLGDGSLPATPIAARFPLSRAGAAHEFLEHNTTAVGRVVLKPGW
>NC_016113.1|WP_014151277.1|906898_907717_+|enoyl-CoA-hydratase/isomerase-family-protein
MKQESRQDRFEDQDEDRFAAQESIECSRLGDGIALAEFSGAHEQNPFSRARMRELTALMRELDADEKVRCVVLYGGAGRSFGVGGDFHEVSEFTGGDEVNAWIDDITDLYTTVAAISKPVIAAIDGYAIGVGLQISLCCDYRLGSEQARLVMPEFRVGIACNFGGFMLEAAAGRTVMQRMLLTCDEWPAERALADGLLHETVASPRLLDRALELARTISGYTAEAVQSTRPRVNAPFVAGLERIRREAKESHRRAFAAGEAQVRMRRVIGRS
>NC_016113.1|WP_014151278.1|907700_908684_-|GNAT-family-N-acetyltransferase
MSPRRLVPIRPADHLPALVRLAADRDRAALGRVEVGATWIAGRLAAPGLDPEHDTALLTGSDGQVAGAVWLSRSSGRSAWDAELLLAPHATPDDAASLLDFAHRRCRTIAAGRPEGEVCLSCFVSERETALRIALSAYGFAAPRPYLRMSVPLGGATAGEPPVPGAVVRVPEGEAGLRAFHAVKNRAFSAEEAGMEPDGFEEWLRWTGADPGADPSQRALLELDGEPVGFANVTDRMAQTRGAAYLRQIGVLPRMRGRRLGAFLLRSVMAAARARGRGEMVLTVDTGNRAGLALYRATGWREESRFYDYAYRVTATPAPAGEVSSAR

Crispr_ID: NC_016113_4

• CRISPR_ID: NC_016113_4
• CRISPR_location: 1163967-1164131
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NC_016113_4

Consensus_repeat	Method
AACGTTGTGAGCGCTCACACCCCACCTCACACCCCC	PILER-CR

spacers of NC_016113_4

>4.1|1164004|39|NC_016113|PILER-CR
GTCGGGAGCGCGCTGCACAGTGCACCGGGCACGCAAACG
>4.2|1164080|37|NC_016113|PILER-CR
AACGCCCGCTTCGTCGGGCACGCCGGGCACGCGCCAC

CRISPR arrays and Neighbor proteins around NC_016113_4

CRISPR arrays

The CRISPR arrays of NC_016113_4

>merge|NC_016113|4|1163967-1164131|PILER-CR
GTTGTGAGCGCTCACAGTCGGGAGCGCGCTGCACAGTGCACCGGGCACGCAAACGAACCTTGTGAGCGCTCACATCGCGCCTCGCACCCCCGAACGCCCGCTTCGTCGGGCACGCCGGGCACGCGCCACAACGTTGTGAGCGCTCACACCCCAGCTCACCCCCCC

>NC_016113|4|2|1163967-1164131|PILER-CR
GTTGTGAGCGCTCACAGTCGGGAGCGCGCTGCACAGT	GCACCGGGCACGCAAACGAACCTTGTGAGCGCTCACATC
GCGCCTCGCACCCCCGAACGCCCGCTTCGTCGGGCAC	GCCGGGCACGCGCCACAACGTTGTGAGCGCTCACACC
CCAGCTCACCCCCCC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016113.1|WP_014151545.1|1172570_1173680_+|ketoacyl-ACP-synthase-III	unknown	unknown	gnl|CDD|238426
NC_016113.1|WP_014151547.1|1175081_1175321_-|CDGSH-iron-sulfur-domain-containing-protein	unknown	unknown	gnl|CDD|378163
NC_016113.1|WP_014151533.1|1159656_1160109_-|VOC-family-protein	unknown	unknown	gnl|CDD|380093
NC_016113.1|WP_014151539.1|1164242_1165085_+|DUF2127-domain-containing-protein	unknown	unknown	gnl|CDD|378298
NC_016113.1|WP_014151548.1|1175295_1175952_-|methyltransferase	unknown	unknown	gnl|CDD|184931
NC_016113.1|WP_014151538.1|1163144_1163900_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|187617
NC_016113.1|WP_014151535.1|1160888_1161710_+|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|235914
NC_016113.1|WP_014151541.1|1166857_1167391_-|PadR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|378427
NC_016113.1|WP_014626841.1|1157465_1158272_+|hypothetical-protein	unknown	unknown	unknown
NC_016113.1|WP_014151546.1|1174018_1175044_+|iron-containing-redox-enzyme-family-protein	unknown	unknown	gnl|CDD|379634
NC_016113.1|WP_014151532.1|1159092_1159539_+|DUF1772-domain-containing-protein	unknown	unknown	gnl|CDD|378020
NC_016113.1|WP_157894789.1|1157198_1157372_+|hypothetical-protein	unknown	unknown	unknown
NC_016113.1|WP_014151544.1|1171737_1172415_-|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|223816
NC_016113.1|WP_014151542.1|1167977_1169999_-|NADPH-dependent-2,4-dienoyl-CoA-reductase	unknown	unknown	gnl|CDD|239240
NC_016113.1|WP_014151540.1|1165095_1166745_-|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|274357
NC_016113.1|WP_014151543.1|1170293_1171745_-|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl|CDD|223715
NC_016113.1|WP_014151531.1|1158423_1159002_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|379115
NC_016113.1|WP_014151534.1|1160148_1160748_-|TetR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|380057
NC_016113.1|WP_014151536.1|1161750_1162284_-|DUF4232-domain-containing-protein	unknown	unknown	gnl|CDD|379419
NC_016113.1|WP_014151537.1|1162479_1163136_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|366102

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016113.1|WP_014151548.1|1175295_1175952_-|methyltransferase	gnl|CDD|184931	PRK14967, PRK14967, putative methyltransferase; Provisional.	9.53914e-88
NC_016113.1|WP_014151533.1|1159656_1160109_-|VOC-family-protein	gnl|CDD|380093	pfam18029, Glyoxalase_6, Glyoxalase-like domain. This entry comprises a diverse set of domains related to the Glyoxalase domain. The exact specificity of these proteins is uncertain.	2.80258e-25
NC_016113.1|WP_014151539.1|1164242_1165085_+|DUF2127-domain-containing-protein	gnl|CDD|378298	pfam09900, DUF2127, Predicted membrane protein (DUF2127). This domain, found in various hypothetical prokaryotic and archaeal proteins, has no known function.	1.22025e-27
NC_016113.1|WP_014151536.1|1161750_1162284_-|DUF4232-domain-containing-protein	gnl|CDD|379419	pfam14016, DUF4232, Protein of unknown function (DUF4232). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 177 and 242 amino acids in length. Many members of this family are lipoproteins.	1.84986e-15
NC_016113.1|WP_014151538.1|1163144_1163900_-|SDR-family-oxidoreductase	gnl|CDD|187617	cd05359, ChcA_like_SDR_c, 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs. This subgroup contains classical SDR proteins, including members identified as 1-cyclohexenylcarbonyl coenzyme A reductase. ChcA of Streptomyces collinus is implicated in the final reduction step of shikimic acid to ansatrienin. ChcA shows sequence similarity to the SDR family of NAD-binding proteins, but it lacks the conserved Tyr of the characteristic catalytic site. This subgroup also contains the NADH-dependent enoyl-[acyl-carrier-protein(ACP)] reductase FabL from Bacillus subtilis. This enzyme participates in bacterial fatty acid synthesis, in type II fatty-acid synthases and catalyzes the last step in each elongation cycle. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	5.54104e-68
NC_016113.1|WP_014151535.1|1160888_1161710_+|SDR-family-oxidoreductase	gnl|CDD|235914	PRK07041, PRK07041, SDR family oxidoreductase.	4.04977e-46
NC_016113.1|WP_014151532.1|1159092_1159539_+|DUF1772-domain-containing-protein	gnl|CDD|378020	pfam08592, DUF1772, Domain of unknown function (DUF1772). This domain is of unknown function.	1.73127e-10
NC_016113.1|WP_014151545.1|1172570_1173680_+|ketoacyl-ACP-synthase-III	gnl|CDD|238426	cd00830, KAS_III, Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP. KASIII initiates this process by specifically using acetyl-CoA over acyl-CoA.	6.39415e-82
NC_016113.1|WP_014151541.1|1166857_1167391_-|PadR-family-transcriptional-regulator	gnl|CDD|378427	pfam10400, Vir_act_alpha_C, Virulence activator alpha C-term. This structure is homo-dimeric, and the domain here is the C-terminal half of the structure, often associated with PadR upstream, (pfam03551), which is a transcriptional regulator.	4.43359e-22
NC_016113.1|WP_014151537.1|1162479_1163136_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	4.31178e-08
NC_016113.1|WP_014151544.1|1171737_1172415_-|response-regulator-transcription-factor	gnl|CDD|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.45459e-82
NC_016113.1|WP_014151542.1|1167977_1169999_-|NADPH-dependent-2,4-dienoyl-CoA-reductase	gnl|CDD|239240	cd02930, DCR_FMN, 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the flavin and iron-sulfur cofactors. Metabolism of unsaturated fatty acids requires auxiliary enzymes in addition to those used in b-oxidation. After a given number of cycles through the b-oxidation pathway, those unsaturated fatty acyl-CoAs with double bonds at even-numbered carbon positions contain 2-trans, 4-cis double bonds that can not be modified by enoyl-CoA hydratase. DCR utilizes NADPH to remove the C4-C5 double bond. DCR can catalyze the reduction of both natural fatty acids with cis double bonds, as well as substrates containing trans double bonds. The reaction is initiated by hybrid transfer from NADPH to FAD, which in turn transfers electrons, one at a time, to FMN via the 4Fe-4S cluster. The fully reduced FMN provides a hydrid ion to the C5 atom of substrate, and Tyr and His are proposed to form a catalytic dyad that protonates the C4 atom of the substrate and completes the reaction.	0
NC_016113.1|WP_014151546.1|1174018_1175044_+|iron-containing-redox-enzyme-family-protein	gnl|CDD|379634	pfam14518, Haem_oxygenas_2, Iron-containing redox enzyme. The CADD, Chlamydia protein associating with death domains, crystal structure reveals a dimer of seven-helical bundles. Each bundle contains a di-iron centre adjacent to an internal cavity that forms an active site similar to that of methane mono-oxygenase hydrolase.	2.52419e-54
NC_016113.1|WP_014151543.1|1170293_1171745_-|HAMP-domain-containing-histidine-kinase	gnl|CDD|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	4.38759e-53
NC_016113.1|WP_014151547.1|1175081_1175321_-|CDGSH-iron-sulfur-domain-containing-protein	gnl|CDD|378163	pfam09360, zf-CDGSH, Iron-binding zinc finger CDGSH type. The CDGSH-type zinc finger domain binds iron rather than zinc as a redox-active pH-labile 2Fe-2S cluster. The conserved sequence C-X-C-X2-(S/T)-X3-P-X-C-D-G-(S/A/T)-H is a defining feature of this family. The domain is oriented towards the cytoplasm and is tethered to the mitochondrial membrane by a more N-terminal domain found in higher vertebrates, MitoNEET_N, pfam10660. The domain forms a uniquely folded homo-dimer and spans the outer mitochondrial membrane, orienting the iron-binding residues towards the cytoplasm.	9.56865e-16
NC_016113.1|WP_014151534.1|1160148_1160748_-|TetR-family-transcriptional-regulator	gnl|CDD|380057	pfam17926, TetR_C_21, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present the TetR Transcriptional Repressor found in Streptomyces coelicolor A3. Family members include HTH-type transcriptional repressor sco4008, which is suggested to be a transcriptional repressor of sco4007 responsible for the multidrug resistance system in S. coelicolor A3.	4.16807e-11
NC_016113.1|WP_014151540.1|1165095_1166745_-|sigma-70-family-RNA-polymerase-sigma-factor	gnl|CDD|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	4.21064e-25
NC_016113.1|WP_014151531.1|1158423_1159002_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|379115	pfam13305, WHG, WHG domain. This presumed domain is around 80 amino acids in length. It is found to the C-terminus of a DNA-binding helix-turn-helix domain. This domain may be involved in binding to an as yet unknown ligand that allows a transcriptional regulation response to that molecule. The domain is named WHG after three conserved residues near the C-terminus of the domain.	2.11869e-12

Protein sequences

>NC_016113.1|WP_014151538.1|1163144_1163900_-|SDR-family-oxidoreductase
MTDTPTALVTGGSRGIGAATARHLAARGYRVAVNYFSNRAAADQVVKEITADGGSAFAVRGDVRDDDEAAELVRRAAEGGRLDVLVCNAAAAHFTPTPLRDLPWEDFRGKVTDELAAVYPLTQHALAVMSGQGYGQIVYVSSLLAEGPSAPGMIAHGTAKAALNTFAQFVACEAGPLGVNVNVVSPGYVRTEASAGIPAEVQRRIAERTPLGRVAEPDDVARAIGLLVGSDAGFVTGTVLRVDGGAGASRM
>NC_016113.1|WP_014151537.1|1162479_1163136_-|TetR/AcrR-family-transcriptional-regulator
MDDGARGGAPRGRRREADRNDVRLMRAARAAFAELGWDAPVSEIARRAGIGMGSLYRRYPSKEALAQRMRVLAMDRLTEQATAASARHPDPWTAFTAFLRDAVSDQEPGGPLLRLLGGRLPSTGEVAAAAARLRSALDALVAAAHEADALRRDVGPADVPLLLELLSLRIPAGAERSAELRSRYLELVLDGLRAPASGDPLTGPAPEWRELHAMWNAL
>NC_016113.1|WP_014151536.1|1161750_1162284_-|DUF4232-domain-containing-protein
MRRLLTAAAVASAVAATGLLGAGAATAAVTAPHTGAAACQPGTLKAAVDPSGPEQAGMNHQGTLLRLTNTGTTTCAFSGYAGLALEGAGHSAIPTTVRHGSTYFAQDPGVRQVTLRPGASAWADLVWTHVGQDTVHAKYLQISPTGSNAHSTVAFAQDLDGGRLSVTAWSASKPAIG
>NC_016113.1|WP_014151535.1|1160888_1161710_+|SDR-family-oxidoreductase
MSAATPAPVPVPAPVPVPVRSPLPSGLSGRTAVLIGGSSGIGLAAGVLLRSVGARVVLVGRDADRLEAAVSRVRGAGSEGGEDAVVGVRGDGGDERVLAEVFERVGEVDHVFVTAGGISGAGALTELTAEDVRTNVDSRLWAAFAVARAAAKRLPAGGSLTFSSGILVVRPIPGMAVPLSVVGAVETLTKALAVELAPSRLRVNAVRFGRIDTPLLRSLPGLDSDEAVAAAGSGAPLGRFGTAEEAAAAALFLMANNYVTGQVITVDGGETLA
>NC_016113.1|WP_014151534.1|1160148_1160748_-|TetR-family-transcriptional-regulator
MAYDAEDTRRRIFEAAAAEFAEHGLAGARVDRIATAADANKQAIYLYYGNKEKLFAAVLRAKLEEIRVSVRLDPDAVAESAGQIFDWYQQHPELIRLLLWESLEGGGGLDEIERERRVGFREKVDHLLDGGVARHLPADARVHATQDLLFTIMGLIAWNFAVPRMCRVVLDEESDHAALARRRRTVVEAVRTLAAAPPP
>NC_016113.1|WP_014151533.1|1159656_1160109_-|VOC-family-protein
MPLHWKLVVDSADAPSLADFWAAALGYEVEDPSPLIERLLAAGHLAPDVVAEHHGRRIFRGYAAVRHPDDPYDEISGTGHGRRLLFQNVPEGKSGKNRLHLDIHSEPGTRDALVARLETLGATRDREVDQGPAGHWWIMRDPEGNEFCVA
>NC_016113.1|WP_014151532.1|1159092_1159539_+|DUF1772-domain-containing-protein
MLSALEVFTTVVVGVMVGVEFSVAFVINRILDALPGDSGQLGRAHGGRMLGAVMPVWYITSLVLVAVWAIAGRTHHGTGLIVTAGALLLLSVIMSVLLLVPINNRGKTWTPENRPADWKEQMNRWDRFHYVRVAVIIAAFALLVAALA
>NC_016113.1|WP_014151531.1|1158423_1159002_-|TetR/AcrR-family-transcriptional-regulator
MSVQERKRRERAERERLIVATARELAEQQGWDAVTTRRLAERIEYSQPVLYSHFRGKREIIGAVALEGATEMAVALRVATSAADGPRARVTALARTYLDFATRNPAVYDALFQLDGGLPFANEDTPEPLKDAFAALLESLSEVAGDGVHPGLFTEVFWAALHGLATLTRAGRLPPEDAERRLELLVDRLAIV
>NC_016113.1|WP_014626841.1|1157465_1158272_+|hypothetical-protein
MATERMSFDDLPPAVLVGVQSHAGEILRTEMVIQGYNSQIAARISTADGSFFIKGLRADHGRVWTQHREAEVNPYLRGIAPALLWQVEDAGWVLLGFEALDGHHADYSAGSPDLPKVADLLCRLGEVPCPPIELRHAEQRLAAYAAKPTDVAHFAGDSLLHTDLNNENVLVNGPAYLVDWAWASKGAAWLDAAHWVVWLMAAGKQEPRSAEEWAARVPAWRTAAPEAVTAFALATANLWEEIAGVDPDPWTATVFDASRRWAEYRKAG
>NC_016113.1|WP_157894789.1|1157198_1157372_+|hypothetical-protein
MSAAAVVITHSRPALSLVPAPAERPKLAEPAGLVIVDDVESLTEGTTPGCNDDNPYR
>NC_016113.1|WP_014151539.1|1164242_1165085_+|DUF2127-domain-containing-protein
MASDSEPRNPPGAPPRHRRIAYELIGCGLHGHHLAGTGAARVRPEDAPLVREGDGLRWHRCLRCDAWLPLRPPEHPEREFPPGRDEVTVPLRGKPLRDRYVLRLIALDRLVHFLVLGVLAGSVLLFVDDRARLRGPYYRILDAVQHGVGGTGGTSGHGFLGDLDKAFAAHASTLWVIGAVFAGYAVLEGVEAVGLWFAQRWAEYLTFVATVILLVPEVYELTGRVSATKILTLVINIAVVVYLLIAKRLFGLRGGGRAEQAERDRDSGWQALERVLPSGR
>NC_016113.1|WP_014151540.1|1165095_1166745_-|sigma-70-family-RNA-polymerase-sigma-factor
MTPEHEATVIATARAGDERARDELVAAYLPLVYNIVGRALHGHADVDDVVQETMLRALDGLAGLRDPRRFRAWLVAVTMNQIRRHHRGKQAAAARTGIEELAELPDPGADFADLTIMRLGLAGQRREVAEATRWLDDDDRALLSLWWLEAAGELTRAEVAAALKLPAPCVAVRVQRMKAQLETARLVVRALSASARCRRLEPVVARWDGVPSALWRKRIARHVRDCRTCSGRRRGLIPAQSLLAGLALVPPLLAAAGRPDPDAATVAASFRTDGAGAPAGSRHAARGPRTGGRRPGGHRRPAVRPRAAQLLAGGAAVTAAATVMSVAISSSDAARPTTTAAPAAAQPLQARSAPLPVPATATPSHPAAHRSVPAPATHRPAPSRTVVRPVPRPAATASAAPVPTASPTQGSGPVEQVLALMNRARAEQGLPPYTLSPGLNRSAAAHNTVMGSGCGLSHQCPGEPPLGDRETAQGVHWGAAGENIGRATAGPDDQQIATAAVGLTQDMLDERPPDDGHRRNILSATFTHVGIAVHRDPDGTVWLTQDFSD
>NC_016113.1|WP_014151541.1|1166857_1167391_-|PadR-family-transcriptional-regulator
MSLPHAILTALLEKPSSGLELTRRFDKSIGYFWSATHQQIYRELGRLEQAGLIRALPTAQPARGQKKEYEVLPAGRAELTAWATAGQDPKPMRDALLLRIRAAAVVGTEGLDAELHRHLDLHRRQLGHYREIEQRDFPPERQAPEDRLRHLVLRGGIELERFWIGWLQEAISTLREN
>NC_016113.1|WP_014151542.1|1167977_1169999_-|NADPH-dependent-2,4-dienoyl-CoA-reductase
MSAYPHLFTPLDLGFTTLPNRVLMGSMHVGLEEAEGGFERMAAFYAARARGGAGLIVTGGIAPNDRGRPYPGGAKLTTGAEAEEHTRVTAAVHREGGRIALQILHFGRYAYHPDLVAPSALQAPISPHVPHALTDDEVEETIEDFVRTAELARLAGYDGVEIMGSEGYLINEFIAAATNHRTDRWGGCYENRVRFPVEIVRRVRERVGPDFIVIYRLSMLDLVPGGSTLEEVVALAKEIEAAGATIINTGIGWHEARIPTIATSVPRGAFAWVTRELMGAVSVPLVATNRINTPEKAEELLASGHADLISMARPMLADPDFVAKARAGRAGTINTCIGCNQACLDHTFSGRITSCLVNPRACHETELVLSPTRHARRVAVVGAGPAGLACAVSAAERGHHVTLYDAADAIGGQLRVAARIPGKGEFHETLRYFRVQLEEHGVEVRLGHRVTPEAFAPGEYDDIVVATGVTPRVPEIDGIGHPSVTGYLDVLGGRVRAGRRVAVIGAGGIGFDVAEYLTDPGDAASEDPAAYFRRWGVDPRYRAPGGLGRPDHPAVPRAVHLLQRKPGKVGAGLGKTTGWIHRTELRHRGVTTLAGVTYRRIDDEGLHITVDGEDHTLAVDTVVVCAGQEPDRALFDALRTAGHRVHLIGGADIAAELDAKRAIDQGTRLAATL
>NC_016113.1|WP_014151543.1|1170293_1171745_-|HAMP-domain-containing-histidine-kinase
MADRRAGRERRRAPRWRGSVRARTTAASTLVVAVALVGAGGAVLAVLHRNLVDATSLQAEVTAREVATQITNGAEFSSLALPNAENQPVQVVKSDGTVLAAGPRLRGAPPFAGFAPAPRQPRRPADPDDRVYVPGSAATTVRFDTVRFRLPGVADARPYRVAAVYAATARDHIVTVYAGASLNTERQAITSARNVMMLGLLPLIAVIALASWLVTRRALRPVEAIRAELAEIMKGDLSRRVPQPDARDEVARLAATTNATLAALEESAGRQRRFIADASHELRSPITSLRTQLEVARAHPELLEIGGLIDDTLRLERLASDLLLLARLDAGEPPRTERVDLAALVREELAHRAADRVPVTAALPGRPTAVTGNRAQLAHVLGNLVDNAQRHAVSAVTVTVRRADDRVTLEVADDGPGVPAADRERIFERFVRLDDARSRDDGGSGLGLAIVRNLTHRHLGTIEVTEAPGGGARFVTTLPAAPG
>NC_016113.1|WP_014151544.1|1171737_1172415_-|response-regulator-transcription-factor
MRLLIVEDERRLAVTLARGLVADGFAVDVAHDGVQGLHMAATGTYDLVVLDLMLPGMSGYRVCARLRVDGDTTPILMLTAKDGEYDEAEGLDTGADDYLTKPFSYVVLLARIRALLRRRTRGGTPVLRLGTLTVDPAARRCFREDREVPLTAKEFAVLEHLAVHAGQVVSKAEILDHVWDFAYDGDPNIVEVYISALRRKIDAPFGRRSITTARGAGYRLAADGG
>NC_016113.1|WP_014151545.1|1172570_1173680_+|ketoacyl-ACP-synthase-III
MDTRLPIGIVSTGSHLPDAVVGNDEIAARTGVTAEWIERTTGVRERRRAAPYEATSDLAAVAAERAIEQAGLAAGQLSCLVVATCTSDHPQPATAAVVGRLIGARRAVAFDVNATGGGFLCGYAAAERMLRGEPAGSYALVVGADVCSRLAGPADPRGAALLGDGAGAVVLGRVPAGQGTLATVLSGCADGSGAVAEPAPEDRAPHENAGYLTTAGPGGRAVAVRRLRQAVERALRTSGRRPHEVRHFVPQQCDGALLDAVWPRLGLDAGYLHLALSRHGNTGSASIPLTLDKVHREGLLSEDDLVLLCGLGGGGPAGSVLLRWTATRYARSASGGLASFLRHRLPAPAAPDRHGPAVPAAGLRAARPA
>NC_016113.1|WP_014151546.1|1174018_1175044_+|iron-containing-redox-enzyme-family-protein
MTTTAAPATPRAVPAPPAPRGPVSAAITAALRRPPPAGPLPCDEAARADPYGDDLQLALHLCYELHYRGFAGTDPAWEWDPELLRLRGALEDVFLRALRDEVAGGTDLDGELSALLTEPVEGTGVSHHLVGEGTWEHLREFFAHRSVYHLKEADPHAWVIPRLRGRAKAALVAVEFDEYGGGRAERVHATLFADLLAAAGLDPGYGGYVPVAPAVALAPVNLMSCLGLHRALRGALVGHFTAAEITTAPSARRLVRALDRLAAPEPCRRFYREHIEADAVHEQVMRHEVIGGLLTDEPDLAADVVFGIQATNVLEERLGGHLLDHWRRGVTSLREPLPGAS
>NC_016113.1|WP_014151547.1|1175081_1175321_-|CDGSH-iron-sulfur-domain-containing-protein
MPTGPHDADDHTGEERPDGREPRRITVVRDGPLLVEGPVEVVLPDGTTASSDRFLVAICTCRRSRAYPWCDTSHRRRAR
>NC_016113.1|WP_014151548.1|1175295_1175952_-|methyltransferase
MLLRLPGVYPPQRDTWLLVRALRAAAPPPGARVLDVCSGTGALALAAAAAGAGPVTAVDVSRRAVWAARANAALRGRRVRVLRGDLLTPVGGELFDVIVANPPYVAAGAPFPARGAARGWDAGADGRAVLDRICRRAPALLAPDGTLLLVHSALSGTGRTLAMLRCRGLKAAVVDRATVPFGPVMRSRAPWLRERGLIDAGTRTEELVVIRADRPARR

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_016113_1	1.2|880124|23|NC_016113|PILER-CR	880124-880146	23	NC_016113.1	1193724-1193746	2	0.913

1. spacer 1.2|880124|23|NC_016113|PILER-CR matches to position: 1193724-1193746, mismatch: 2, identity: 0.913

ggcgccgaccccggcaacccggc	CRISPR spacer
ggcgccgacccccgaaacccggc	Protospacer
************ * ********

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_016113_1	1.1|880044|46|NC_016113|PILER-CR	880044-880089	46	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	933071-933116	0	1.0
NC_016113_1	1.1|880044|46|NC_016113|PILER-CR	880044-880089	46	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	880038-880083	0	1.0
NC_016113_1	1.2|880124|23|NC_016113|PILER-CR	880124-880146	23	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	933024-933046	0	1.0
NC_016113_1	1.2|880124|23|NC_016113|PILER-CR	880124-880146	23	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	880108-880130	0	1.0
NC_016113_2	2.1|898072|34|NC_016113|CRT	898072-898105	34	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	915049-915082	0	1.0
NC_016113_2	2.1|898072|34|NC_016113|CRT	898072-898105	34	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	898072-898105	0	1.0
NC_016113_2	2.2|898133|34|NC_016113|CRT	898133-898166	34	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	914988-915021	0	1.0
NC_016113_2	2.2|898133|34|NC_016113|CRT	898133-898166	34	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	898133-898166	0	1.0
NC_016113_2	2.3|898194|34|NC_016113|CRT	898194-898227	34	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	898194-898227	0	1.0
NC_016113_2	2.3|898194|34|NC_016113|CRT	898194-898227	34	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	914927-914960	0	1.0
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	898255-898286	0	1.0
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	914868-914899	0	1.0
NC_016113_3	3.1|899012|59|NC_016113|CRISPRCasFinder	899012-899070	59	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	899012-899070	0	1.0
NC_016113_3	3.1|899012|59|NC_016113|CRISPRCasFinder	899012-899070	59	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	914084-914142	0	1.0
NC_016113_4	4.1|1164004|39|NC_016113|PILER-CR	1164004-1164042	39	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	1163983-1164021	0	1.0
NC_016113_4	4.1|1164004|39|NC_016113|PILER-CR	1164004-1164042	39	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	649543-649581	0	1.0
NC_016113_4	4.2|1164080|37|NC_016113|PILER-CR	1164080-1164116	37	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	1164059-1164095	0	1.0
NC_016113_4	4.2|1164080|37|NC_016113|PILER-CR	1164080-1164116	37	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	649469-649505	0	1.0
NC_016113_1	1.2|880124|23|NC_016113|PILER-CR	880124-880146	23	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	619818-619840	2	0.913
NC_016113_1	1.2|880124|23|NC_016113|PILER-CR	880124-880146	23	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	1193724-1193746	2	0.913
NC_016113_1	1.2|880124|23|NC_016113|PILER-CR	880124-880146	23	KC787101	Mycobacterium phage 33D, partial genome	25893-25915	2	0.913
NC_016113_1	1.2|880124|23|NC_016113|PILER-CR	880124-880146	23	AF068845	Mycobacteriophage TM4, complete genome	22498-22520	2	0.913
NC_016113_1	1.2|880124|23|NC_016113|PILER-CR	880124-880146	23	NC_003387	Mycobacterium phage TM4, complete genome	22498-22520	2	0.913
NC_016113_1	1.2|880124|23|NC_016113|PILER-CR	880124-880146	23	NZ_CP030772	Streptomyces sp. YIM 121038 plasmid pSSP121038, complete sequence	150784-150806	3	0.87
NC_016113_1	1.2|880124|23|NC_016113|PILER-CR	880124-880146	23	NZ_CP034351	Streptomyces sp. W1SF4 plasmid p1, complete sequence	183828-183850	3	0.87
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_CP017076	Novosphingobium resinovorum strain SA1 plasmid pSA1, complete sequence	1147744-1147775	6	0.812
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	MN103533	Mycobacterium phage Weirdo19, complete genome	23995-24026	6	0.812
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_AP022333	Methylosinus sp. C49 isolate Methylosinus sp. C49 plasmid pMSC49a, complete sequence	249268-249299	6	0.812
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_CP044332	Methylocystis parvus strain BRCS2 plasmid unnamed1, complete sequence	215140-215171	6	0.812
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NC_008270	Rhodococcus jostii RHA1 plasmid pRHL2, complete sequence	268853-268884	7	0.781
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_AP022335	Methylosinus sp. C49 isolate Methylosinus sp. C49 plasmid pMSC49c, complete sequence	161255-161286	7	0.781
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_CP006369	Aureimonas sp. AU20 plasmid pAU20b, complete sequence	174882-174913	7	0.781
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	MG198783	Gordonia phage Mahdia, complete genome	40343-40374	7	0.781
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	MN908691	Gordonia phage DatBoi, complete genome	33070-33101	7	0.781
NC_016113_2	2.2|898133|34|NC_016113|CRT	898133-898166	34	NC_008043	Ruegeria sp. TM1040 megaplasmid, complete sequence	391141-391174	8	0.765
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NC_022125	Rhodococcus erythropolis CCM2595 plasmid pRECF1, complete sequence	62123-62154	8	0.75
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_CP015203	Rhodococcus sp. 008 plasmid pR8L1, complete sequence	153778-153809	8	0.75
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_CP049158	Caballeronia sp. SBC1 plasmid pSBC1_2, complete sequence	491916-491947	8	0.75
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NC_007491	Rhodococcus erythropolis PR4 plasmid pREL1, complete sequence	141747-141778	8	0.75
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_CP044283	Rhodococcus erythropolis strain X5 plasmid pRhX5, complete sequence	14250-14281	8	0.75
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_CP049318	Caballeronia sp. SBC2 plasmid pSBC2-2, complete sequence	491125-491156	8	0.75
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NC_010335	Caulobacter sp. K31 plasmid pCAUL01, complete sequence	141227-141258	8	0.75
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_CP017303	Rhodococcus sp. YL-1 plasmid pYLL1 sequence	378853-378884	8	0.75
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_CP017304	Rhodococcus sp. YL-1 plasmid pYLL2 sequence	325263-325294	8	0.75
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_CP050125	Rhodococcus erythropolis strain KB1 plasmid plas1, complete sequence	13531-13562	8	0.75
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NC_005073	Rhodococcus erythropolis linear plasmid pBD2, complete sequence	129730-129761	8	0.75
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_CP024313	Rhizobium sp. NXC24 plasmid pRspNXC24b, complete sequence	302915-302946	8	0.75
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_CP042915	Rhodococcus qingshengii strain RL1 plasmid unnamed2	122099-122130	8	0.75
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_CP019604	Croceicoccus marinus strain E4A9 plasmid pCME4A9II, complete sequence	13613-13644	8	0.75
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_CP035092	Paracoccus denitrificans strain ATCC 19367 plasmid unnamed1, complete sequence	307947-307978	8	0.75
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_CP022367	Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence	1797533-1797564	8	0.75
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NC_008688	Paracoccus denitrificans PD1222 plasmid 1, complete sequence	555295-555326	8	0.75
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_CP032346	Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence	310521-310552	8	0.75
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_CP032346	Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence	1566343-1566374	8	0.75
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	MN908694	Microbacterium phage RubyRalph, complete genome	4100-4131	8	0.75
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_AP014801	Rhodovulum sulfidophilum plasmid Plasmid1 DNA, complete genome, strain: DSM 2351	42040-42071	8	0.75
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_CP032340	Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence	256238-256269	8	0.75
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_CP026517	Deinococcus sp. NW-56 plasmid unnamed1, complete sequence	43918-43949	8	0.75
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_CP012915	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence	129770-129801	8	0.75
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_CP030354	Novosphingobium sp. P6W plasmid pP6W1, complete sequence	478686-478717	9	0.719
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_CP022363	Azospirillum sp. TSH58 plasmid TSH58_p03, complete sequence	400002-400033	9	0.719
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NC_007974	Cupriavidus metallidurans CH34 megaplasmid, complete sequence	587914-587945	9	0.719
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_CP046333	Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3	459306-459337	9	0.719
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_AP014705	Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence	293789-293820	9	0.719
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_CP030074	Streptomyces sp. ZFG47 plasmid unnamed1, complete sequence	439117-439148	9	0.719
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	MK977708	Mycobacterium phage Fulbright, complete genome	4951-4982	9	0.719
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	MG099948	Mycobacterium phage Philonius, complete genome	4951-4982	9	0.719
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	MH926055	Mycobacterium phage Chewbacca, complete genome	4951-4982	9	0.719
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	MT723932	Mycobacterium phage Schnauzer, complete genome	4951-4982	9	0.719
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	KU935726	Mycobacterium phage Xerxes, complete genome	4951-4982	9	0.719
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	KU935730	Mycobacterium phage Pipsqueaks, complete genome	4951-4982	9	0.719
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	MH316570	Mycobacterium phage Silvafighter, complete genome	4951-4982	9	0.719
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	MK524518	Mycobacterium phage Smurph, complete genome	4951-4982	9	0.719
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	MK524515	Mycobacterium phage Parmesanjohn, complete genome	4951-4982	9	0.719
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	MH697585	Mycobacterium phage Gex, complete genome	4951-4982	9	0.719
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	KM588359	Mycobacterium phage Carcharodon, complete genome	4951-4982	9	0.719
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	MH697576	Mycobacterium phage Aggie, complete genome	4951-4982	9	0.719
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	MH697593	Mycobacterium phage Tapioca, complete genome	4951-4982	9	0.719
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	MG099936	Mycobacterium phage Andies, complete genome	4951-4982	9	0.719
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NC_031243	Mycobacterium phage Xeno, complete genome	4951-4982	9	0.719
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	JN256079	Mycobacterium phage Charlie, complete genome	4951-4982	9	0.719
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_CP039697	Novosphingobium sp. ABRDHK2 plasmid pABRDHK22, complete sequence	705837-705868	9	0.719
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_CP011515	Mitsuaria sp. 7 plasmid, complete sequence	106613-106644	9	0.719
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_CP034650	Xanthomonas vasicola strain NCPPB 1060 plasmid pXVH29, complete sequence	25190-25221	9	0.719
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_CP043499	Rhizobium grahamii strain BG7 plasmid unnamed, complete sequence	64642-64673	9	0.719
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	AP017627	Pleomorphomonas sp. SM30 plasmid pSM30-1 DNA, complete genome	5953-5984	9	0.719
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NC_019320	Variovorax sp. DB1 plasmid pDB1, complete sequence	13810-13841	9	0.719
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_CP032156	Mycobacterium sp. ELW1 plasmid pELW1-1, complete sequence	52409-52440	9	0.719
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	MT028492	Ochrobactrum phage vB_OspP_OH, complete genome	21864-21895	9	0.719
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_CP007794	Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence	1434949-1434980	10	0.688
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	4817412-4817443	10	0.688
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_CP006369	Aureimonas sp. AU20 plasmid pAU20b, complete sequence	252601-252632	10	0.688
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_CP032322	Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence	1616240-1616271	10	0.688
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_CP013503	Rhizobium esperanzae strain N561 plasmid pRspN561c, complete sequence	149226-149257	10	0.688
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_CP013509	Rhizobium sp. N1341 plasmid pRspN1341d, complete sequence	149226-149257	10	0.688
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_CP013520	Rhizobium sp. N113 plasmid pRspN113c, complete sequence	149226-149257	10	0.688
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_CP013493	Rhizobium sp. N6212 plasmid pRspN6212c, complete sequence	149226-149257	10	0.688
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_CP013516	Rhizobium sp. N1314 plasmid pRspN1314e, complete sequence	146886-146917	10	0.688
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_CP032340	Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence	744930-744961	10	0.688
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_CP012915	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence	1387454-1387485	10	0.688
NC_016113_2	2.4|898255|32|NC_016113|CRT	898255-898286	32	NZ_LR134460	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 18, complete sequence	287394-287425	11	0.656

1. spacer 1.1|880044|46|NC_016113|PILER-CR matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 0, identity: 1.0

gccccaacctcccgcgcgcccgcccctcacagcgcggccctccgaa	CRISPR spacer
gccccaacctcccgcgcgcccgcccctcacagcgcggccctccgaa	Protospacer
**********************************************

2. spacer 1.1|880044|46|NC_016113|PILER-CR matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 0, identity: 1.0

gccccaacctcccgcgcgcccgcccctcacagcgcggccctccgaa	CRISPR spacer
gccccaacctcccgcgcgcccgcccctcacagcgcggccctccgaa	Protospacer
**********************************************

3. spacer 1.2|880124|23|NC_016113|PILER-CR matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 0, identity: 1.0

ggcgccgaccccggcaacccggc	CRISPR spacer
ggcgccgaccccggcaacccggc	Protospacer
***********************

4. spacer 1.2|880124|23|NC_016113|PILER-CR matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 0, identity: 1.0

ggcgccgaccccggcaacccggc	CRISPR spacer
ggcgccgaccccggcaacccggc	Protospacer
***********************

5. spacer 2.1|898072|34|NC_016113|CRT matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 0, identity: 1.0

tttgcgccaggtccgcagactgcgggttttggca	CRISPR spacer
tttgcgccaggtccgcagactgcgggttttggca	Protospacer
**********************************

6. spacer 2.1|898072|34|NC_016113|CRT matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 0, identity: 1.0

tttgcgccaggtccgcagactgcgggttttggca	CRISPR spacer
tttgcgccaggtccgcagactgcgggttttggca	Protospacer
**********************************

7. spacer 2.2|898133|34|NC_016113|CRT matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 0, identity: 1.0

tctccgcggcggagcgcaggtggtcctccgccta	CRISPR spacer
tctccgcggcggagcgcaggtggtcctccgccta	Protospacer
**********************************

8. spacer 2.2|898133|34|NC_016113|CRT matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 0, identity: 1.0

tctccgcggcggagcgcaggtggtcctccgccta	CRISPR spacer
tctccgcggcggagcgcaggtggtcctccgccta	Protospacer
**********************************

9. spacer 2.3|898194|34|NC_016113|CRT matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 0, identity: 1.0

ggtacacggggctacggacgactaccggcaggcg	CRISPR spacer
ggtacacggggctacggacgactaccggcaggcg	Protospacer
**********************************

10. spacer 2.3|898194|34|NC_016113|CRT matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 0, identity: 1.0

ggtacacggggctacggacgactaccggcaggcg	CRISPR spacer
ggtacacggggctacggacgactaccggcaggcg	Protospacer
**********************************

11. spacer 2.4|898255|32|NC_016113|CRT matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 0, identity: 1.0

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
tggacggccggggcgatcggcgtcgccgcgct	Protospacer
********************************

12. spacer 2.4|898255|32|NC_016113|CRT matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 0, identity: 1.0

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
tggacggccggggcgatcggcgtcgccgcgct	Protospacer
********************************

13. spacer 3.1|899012|59|NC_016113|CRISPRCasFinder matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 0, identity: 1.0

ggccaacggtgccagttgaccggcgacggaacgaggcgatccgcaacggtgatggtgtc	CRISPR spacer
ggccaacggtgccagttgaccggcgacggaacgaggcgatccgcaacggtgatggtgtc	Protospacer
***********************************************************

14. spacer 3.1|899012|59|NC_016113|CRISPRCasFinder matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 0, identity: 1.0

ggccaacggtgccagttgaccggcgacggaacgaggcgatccgcaacggtgatggtgtc	CRISPR spacer
ggccaacggtgccagttgaccggcgacggaacgaggcgatccgcaacggtgatggtgtc	Protospacer
***********************************************************

15. spacer 4.1|1164004|39|NC_016113|PILER-CR matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 0, identity: 1.0

gtcgggagcgcgctgcacagtgcaccgggcacgcaaacg	CRISPR spacer
gtcgggagcgcgctgcacagtgcaccgggcacgcaaacg	Protospacer
***************************************

16. spacer 4.1|1164004|39|NC_016113|PILER-CR matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 0, identity: 1.0

gtcgggagcgcgctgcacagtgcaccgggcacgcaaacg	CRISPR spacer
gtcgggagcgcgctgcacagtgcaccgggcacgcaaacg	Protospacer
***************************************

17. spacer 4.2|1164080|37|NC_016113|PILER-CR matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 0, identity: 1.0

aacgcccgcttcgtcgggcacgccgggcacgcgccac	CRISPR spacer
aacgcccgcttcgtcgggcacgccgggcacgcgccac	Protospacer
*************************************

18. spacer 4.2|1164080|37|NC_016113|PILER-CR matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 0, identity: 1.0

aacgcccgcttcgtcgggcacgccgggcacgcgccac	CRISPR spacer
aacgcccgcttcgtcgggcacgccgggcacgcgccac	Protospacer
*************************************

19. spacer 1.2|880124|23|NC_016113|PILER-CR matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 2, identity: 0.913

ggcgccgaccccggcaacccggc	CRISPR spacer
ggcgccgacccccgaaacccggc	Protospacer
************ * ********

20. spacer 1.2|880124|23|NC_016113|PILER-CR matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 2, identity: 0.913

ggcgccgaccccggcaacccggc	CRISPR spacer
ggcgccgacccccgaaacccggc	Protospacer
************ * ********

21. spacer 1.2|880124|23|NC_016113|PILER-CR matches to KC787101 (Mycobacterium phage 33D, partial genome) position: , mismatch: 2, identity: 0.913

ggcgccgaccccggcaacccggc	CRISPR spacer
ggcgccgaccccgacgacccggc	Protospacer
*************.*.*******

22. spacer 1.2|880124|23|NC_016113|PILER-CR matches to AF068845 (Mycobacteriophage TM4, complete genome) position: , mismatch: 2, identity: 0.913

ggcgccgaccccggcaacccggc	CRISPR spacer
ggcgccgaccccgacgacccggc	Protospacer
*************.*.*******

23. spacer 1.2|880124|23|NC_016113|PILER-CR matches to NC_003387 (Mycobacterium phage TM4, complete genome) position: , mismatch: 2, identity: 0.913

ggcgccgaccccggcaacccggc	CRISPR spacer
ggcgccgaccccgacgacccggc	Protospacer
*************.*.*******

24. spacer 1.2|880124|23|NC_016113|PILER-CR matches to NZ_CP030772 (Streptomyces sp. YIM 121038 plasmid pSSP121038, complete sequence) position: , mismatch: 3, identity: 0.87

ggcgccgaccccggcaacccggc	CRISPR spacer
ctcgccgaccccggcaacccgga	Protospacer
  ******************** 

25. spacer 1.2|880124|23|NC_016113|PILER-CR matches to NZ_CP034351 (Streptomyces sp. W1SF4 plasmid p1, complete sequence) position: , mismatch: 3, identity: 0.87

ggcgccgaccccggcaacccggc	CRISPR spacer
cccgccgaccccggcgacccggc	Protospacer
  *************.*******

26. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_CP017076 (Novosphingobium resinovorum strain SA1 plasmid pSA1, complete sequence) position: , mismatch: 6, identity: 0.812

tggac---ggccggggcgatcggcgtcgccgcgct	CRISPR spacer
---acccatgccggagcgctcggcgtcgccgcgct	Protospacer
   **    *****.*** ****************

27. spacer 2.4|898255|32|NC_016113|CRT matches to MN103533 (Mycobacterium phage Weirdo19, complete genome) position: , mismatch: 6, identity: 0.812

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
tcggcggccgaggcgatcggggtcgccgcggc	Protospacer
* *.******.********* ********* .

28. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_AP022333 (Methylosinus sp. C49 isolate Methylosinus sp. C49 plasmid pMSC49a, complete sequence) position: , mismatch: 6, identity: 0.812

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
tcgagcgccgtggcgatcggcgtcgcctcgcc	Protospacer
* **  **** **************** ***.

29. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_CP044332 (Methylocystis parvus strain BRCS2 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.812

--tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gatagatgg--ggtgcgatcggcgccgccgcgct	Protospacer
  *.**.**  ** **********.*********

30. spacer 2.4|898255|32|NC_016113|CRT matches to NC_008270 (Rhodococcus jostii RHA1 plasmid pRHL2, complete sequence) position: , mismatch: 7, identity: 0.781

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
acggctgccgcggcgagcggcgtcgccgcgcc	Protospacer
  *.* **** ***** **************.

31. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_AP022335 (Methylosinus sp. C49 isolate Methylosinus sp. C49 plasmid pMSC49c, complete sequence) position: , mismatch: 7, identity: 0.781

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
tcgcaggccggggcgttcggcgtggccgcagt	Protospacer
* *  ********** ******* *****. *

32. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_CP006369 (Aureimonas sp. AU20 plasmid pAU20b, complete sequence) position: , mismatch: 7, identity: 0.781

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
acgaggaacggagcgatcgacgtcgccgcgct	Protospacer
  ** *. ***.*******.************

33. spacer 2.4|898255|32|NC_016113|CRT matches to MG198783 (Gordonia phage Mahdia, complete genome) position: , mismatch: 7, identity: 0.781

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
tcggcggccggggccatcggcgtccccgaggc	Protospacer
* *.********** ********* *** * .

34. spacer 2.4|898255|32|NC_016113|CRT matches to MN908691 (Gordonia phage DatBoi, complete genome) position: , mismatch: 7, identity: 0.781

tggacggccggggcgatcggcgtcgcc-gcgct	CRISPR spacer
ggcccggccgcggccatcggcgtcgccagcga-	Protospacer
 *  ****** *** ************ ***  

35. spacer 2.2|898133|34|NC_016113|CRT matches to NC_008043 (Ruegeria sp. TM1040 megaplasmid, complete sequence) position: , mismatch: 8, identity: 0.765

tctccgcggcggagcgcaggtggtcctccgccta-	CRISPR spacer
aggacgcggcggggcgcaggtgatcct-cgccgat	Protospacer
    ********.*********.**** **** * 

36. spacer 2.4|898255|32|NC_016113|CRT matches to NC_022125 (Rhodococcus erythropolis CCM2595 plasmid pRECF1, complete sequence) position: , mismatch: 8, identity: 0.75

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
ctcgcggccgggacgatcagcgtcgccgccat	Protospacer
.  .********.*****.**********  *

37. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_CP015203 (Rhodococcus sp. 008 plasmid pR8L1, complete sequence) position: , mismatch: 8, identity: 0.75

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gtcgcggccgggacgatcagcgtcgccgccat	Protospacer
   .********.*****.**********  *

38. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_CP049158 (Caballeronia sp. SBC1 plasmid pSBC1_2, complete sequence) position: , mismatch: 8, identity: 0.75

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
caagcggccggcgcgataggcgtcgccgcatt	Protospacer
....******* ***** ***********..*

39. spacer 2.4|898255|32|NC_016113|CRT matches to NC_007491 (Rhodococcus erythropolis PR4 plasmid pREL1, complete sequence) position: , mismatch: 8, identity: 0.75

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gtcgcggccgggacgatcagcgtcgccgccat	Protospacer
   .********.*****.**********  *

40. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_CP044283 (Rhodococcus erythropolis strain X5 plasmid pRhX5, complete sequence) position: , mismatch: 8, identity: 0.75

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gtcgcggccgggacgatcagcgtcgccgccat	Protospacer
   .********.*****.**********  *

41. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_CP049318 (Caballeronia sp. SBC2 plasmid pSBC2-2, complete sequence) position: , mismatch: 8, identity: 0.75

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
caagcggccggcgcgataggcgtcgccgcatt	Protospacer
....******* ***** ***********..*

42. spacer 2.4|898255|32|NC_016113|CRT matches to NC_010335 (Caulobacter sp. K31 plasmid pCAUL01, complete sequence) position: , mismatch: 8, identity: 0.75

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gcggcggccggggcgatcggcctggccgccac	Protospacer
  *.***************** * *****  .

43. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_CP017303 (Rhodococcus sp. YL-1 plasmid pYLL1 sequence) position: , mismatch: 8, identity: 0.75

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gtcgcggccgggacgatcagcgtcgccgccat	Protospacer
   .********.*****.**********  *

44. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_CP017304 (Rhodococcus sp. YL-1 plasmid pYLL2 sequence) position: , mismatch: 8, identity: 0.75

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gtcgcggccgggacgatcagcgtcgccgccat	Protospacer
   .********.*****.**********  *

45. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_CP050125 (Rhodococcus erythropolis strain KB1 plasmid plas1, complete sequence) position: , mismatch: 8, identity: 0.75

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gtcgcggccgggacgatcagcgtcgccgccat	Protospacer
   .********.*****.**********  *

46. spacer 2.4|898255|32|NC_016113|CRT matches to NC_005073 (Rhodococcus erythropolis linear plasmid pBD2, complete sequence) position: , mismatch: 8, identity: 0.75

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
ctcgcggccgggacgatcagcgtcgccgccat	Protospacer
.  .********.*****.**********  *

47. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_CP024313 (Rhizobium sp. NXC24 plasmid pRspNXC24b, complete sequence) position: , mismatch: 8, identity: 0.75

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gagggtgccggggcgatcggcatcgccgcttt	Protospacer
 .*.  ***************.******* .*

48. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_CP042915 (Rhodococcus qingshengii strain RL1 plasmid unnamed2) position: , mismatch: 8, identity: 0.75

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gtcgcggccgggacgatcagcgtcgccgccat	Protospacer
   .********.*****.**********  *

49. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_CP019604 (Croceicoccus marinus strain E4A9 plasmid pCME4A9II, complete sequence) position: , mismatch: 8, identity: 0.75

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
aagccggccgggctgatcggcgtcgccgatcc	Protospacer
 .* ******** .**************  *.

50. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_CP035092 (Paracoccus denitrificans strain ATCC 19367 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.75

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gagcggggcggggcgatcggagtcgccgctca	Protospacer
 .*  ** ************ ******** * 

51. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_CP022367 (Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence) position: , mismatch: 8, identity: 0.75

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
atcacctccggggtcatcggcgtcgccgcgca	Protospacer
   **  ******. **************** 

52. spacer 2.4|898255|32|NC_016113|CRT matches to NC_008688 (Paracoccus denitrificans PD1222 plasmid 1, complete sequence) position: , mismatch: 8, identity: 0.75

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gagcggggcggggcgatcggagtcgccgctca	Protospacer
 .*  ** ************ ******** * 

53. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_CP032346 (Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence) position: , mismatch: 8, identity: 0.75

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
ataacctccggggtcatcggcgtcgccgcgca	Protospacer
  .**  ******. **************** 

54. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_CP032346 (Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence) position: , mismatch: 8, identity: 0.75

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gtggtggccggggcgaccggcggcgccggcct	Protospacer
  *..***********.***** *****  **

55. spacer 2.4|898255|32|NC_016113|CRT matches to MN908694 (Microbacterium phage RubyRalph, complete genome) position: , mismatch: 8, identity: 0.75

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gaggcggccgcggcgatccgcgtcgccgagtc	Protospacer
 .*.****** ******* ********* *..

56. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_AP014801 (Rhodovulum sulfidophilum plasmid Plasmid1 DNA, complete genome, strain: DSM 2351) position: , mismatch: 8, identity: 0.75

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
ttgcagcccgcgccgatcggcgtcgccgcggc	Protospacer
* *  * *** * ***************** .

57. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_CP032340 (Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence) position: , mismatch: 8, identity: 0.75

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gtggtggccggggcgaccggcggcgccggcct	Protospacer
  *..***********.***** *****  **

58. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_CP026517 (Deinococcus sp. NW-56 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.75

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gcgatggccggggcgatcggcggcggaggcct	Protospacer
  **.***************** **  *  **

59. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_CP012915 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence) position: , mismatch: 8, identity: 0.75

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gtggtggccggggcgaccggcggcgccggcct	Protospacer
  *..***********.***** *****  **

60. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_CP030354 (Novosphingobium sp. P6W plasmid pP6W1, complete sequence) position: , mismatch: 9, identity: 0.719

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
cttcgcaccggggcgctcggcggcgccgcgct	Protospacer
.     .******** ****** *********

61. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_CP022363 (Azospirillum sp. TSH58 plasmid TSH58_p03, complete sequence) position: , mismatch: 9, identity: 0.719

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gcaacggacggggcggtcggcgtcgcccggaa	Protospacer
  .**** *******.***********  *  

62. spacer 2.4|898255|32|NC_016113|CRT matches to NC_007974 (Cupriavidus metallidurans CH34 megaplasmid, complete sequence) position: , mismatch: 9, identity: 0.719

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
tactacgccggggcgatcggcgtcaccccgac	Protospacer
*.    ******************.** ** .

63. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_CP046333 (Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3) position: , mismatch: 9, identity: 0.719

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
tactacgccggggcgatcggcgtcaccccgac	Protospacer
*.    ******************.** ** .

64. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_AP014705 (Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence) position: , mismatch: 9, identity: 0.719

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
agcggcgccagggcgatcagcgtcgccgcggg	Protospacer
 * .  ***.********.***********  

65. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_CP030074 (Streptomyces sp. ZFG47 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.719

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gactcctccggggcgatcggcagcgccgcgcc	Protospacer
 .  *  **************. ********.

66. spacer 2.4|898255|32|NC_016113|CRT matches to MK977708 (Mycobacterium phage Fulbright, complete genome) position: , mismatch: 9, identity: 0.719

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gtgccggccggggcggtcggcatcgccgacga	Protospacer
  * ***********.*****.******    

67. spacer 2.4|898255|32|NC_016113|CRT matches to MG099948 (Mycobacterium phage Philonius, complete genome) position: , mismatch: 9, identity: 0.719

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gtgccggccggggcggtcggcatcgccgacga	Protospacer
  * ***********.*****.******    

68. spacer 2.4|898255|32|NC_016113|CRT matches to MH926055 (Mycobacterium phage Chewbacca, complete genome) position: , mismatch: 9, identity: 0.719

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gtgccggccggggcggtcggcatcgccgacga	Protospacer
  * ***********.*****.******    

69. spacer 2.4|898255|32|NC_016113|CRT matches to MT723932 (Mycobacterium phage Schnauzer, complete genome) position: , mismatch: 9, identity: 0.719

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gtgccggccggggcggtcggcatcgccgacga	Protospacer
  * ***********.*****.******    

70. spacer 2.4|898255|32|NC_016113|CRT matches to KU935726 (Mycobacterium phage Xerxes, complete genome) position: , mismatch: 9, identity: 0.719

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gtgccggccggggcggtcggcatcgccgacga	Protospacer
  * ***********.*****.******    

71. spacer 2.4|898255|32|NC_016113|CRT matches to KU935730 (Mycobacterium phage Pipsqueaks, complete genome) position: , mismatch: 9, identity: 0.719

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gtgccggccggggcggtcggcatcgccgacga	Protospacer
  * ***********.*****.******    

72. spacer 2.4|898255|32|NC_016113|CRT matches to MH316570 (Mycobacterium phage Silvafighter, complete genome) position: , mismatch: 9, identity: 0.719

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gtgccggccggggcggtcggcatcgccgacga	Protospacer
  * ***********.*****.******    

73. spacer 2.4|898255|32|NC_016113|CRT matches to MK524518 (Mycobacterium phage Smurph, complete genome) position: , mismatch: 9, identity: 0.719

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gtgccggccggggcggtcggcatcgccgacga	Protospacer
  * ***********.*****.******    

74. spacer 2.4|898255|32|NC_016113|CRT matches to MK524515 (Mycobacterium phage Parmesanjohn, complete genome) position: , mismatch: 9, identity: 0.719

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gtgccggccggggcggtcggcatcgccgacga	Protospacer
  * ***********.*****.******    

75. spacer 2.4|898255|32|NC_016113|CRT matches to MH697585 (Mycobacterium phage Gex, complete genome) position: , mismatch: 9, identity: 0.719

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gtgccggccggggcggtcggcatcgccgacga	Protospacer
  * ***********.*****.******    

76. spacer 2.4|898255|32|NC_016113|CRT matches to KM588359 (Mycobacterium phage Carcharodon, complete genome) position: , mismatch: 9, identity: 0.719

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gtgccggccggggcggtcggcatcgccgacga	Protospacer
  * ***********.*****.******    

77. spacer 2.4|898255|32|NC_016113|CRT matches to MH697576 (Mycobacterium phage Aggie, complete genome) position: , mismatch: 9, identity: 0.719

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gtgccggccggggcggtcggcatcgccgacga	Protospacer
  * ***********.*****.******    

78. spacer 2.4|898255|32|NC_016113|CRT matches to MH697593 (Mycobacterium phage Tapioca, complete genome) position: , mismatch: 9, identity: 0.719

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gtgccggccggggcggtcggcatcgccgacga	Protospacer
  * ***********.*****.******    

79. spacer 2.4|898255|32|NC_016113|CRT matches to MG099936 (Mycobacterium phage Andies, complete genome) position: , mismatch: 9, identity: 0.719

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gtgccggccggggcggtcggcatcgccgacga	Protospacer
  * ***********.*****.******    

80. spacer 2.4|898255|32|NC_016113|CRT matches to NC_031243 (Mycobacterium phage Xeno, complete genome) position: , mismatch: 9, identity: 0.719

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gtgccggccggggcggtcggcatcgccgacga	Protospacer
  * ***********.*****.******    

81. spacer 2.4|898255|32|NC_016113|CRT matches to JN256079 (Mycobacterium phage Charlie, complete genome) position: , mismatch: 9, identity: 0.719

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gtgccggccggggcggtcggcatcgccgacga	Protospacer
  * ***********.*****.******    

82. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_CP039697 (Novosphingobium sp. ABRDHK2 plasmid pABRDHK22, complete sequence) position: , mismatch: 9, identity: 0.719

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gcgatcagcgcggcgatccgcgtcgccgcgcg	Protospacer
  **. . ** ******* ************ 

83. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_CP011515 (Mitsuaria sp. 7 plasmid, complete sequence) position: , mismatch: 9, identity: 0.719

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
caggtgctgggcgcgatcggcatcgccgcgct	Protospacer
..*..* . ** *********.**********

84. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_CP034650 (Xanthomonas vasicola strain NCPPB 1060 plasmid pXVH29, complete sequence) position: , mismatch: 9, identity: 0.719

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
atcgtgggcggggcgatcggcatcgccgtgtt	Protospacer
   ..** *************.******.*.*

85. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_CP043499 (Rhizobium grahamii strain BG7 plasmid unnamed, complete sequence) position: , mismatch: 9, identity: 0.719

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
tgataggccgaggcgatcggcgtcgacgacaa	Protospacer
**.  *****.************** **    

86. spacer 2.4|898255|32|NC_016113|CRT matches to AP017627 (Pleomorphomonas sp. SM30 plasmid pSM30-1 DNA, complete genome) position: , mismatch: 9, identity: 0.719

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
agcgccaccggggcgcccggcgtcgccgcggc	Protospacer
 * .* .******** .************* .

87. spacer 2.4|898255|32|NC_016113|CRT matches to NC_019320 (Variovorax sp. DB1 plasmid pDB1, complete sequence) position: , mismatch: 9, identity: 0.719

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
ttcgccgccgcggcgatcggcatcgccgccgc	Protospacer
*  .* **** **********.*******  .

88. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_CP032156 (Mycobacterium sp. ELW1 plasmid pELW1-1, complete sequence) position: , mismatch: 9, identity: 0.719

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
ggcgatggcggggcgagcggcgtcgacgcgcc	Protospacer
 * .  * ******** ******** *****.

89. spacer 2.4|898255|32|NC_016113|CRT matches to MT028492 (Ochrobactrum phage vB_OspP_OH, complete genome) position: , mismatch: 9, identity: 0.719

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
tcttgtgccggggcgggcggcgtcgccgccat	Protospacer
*     *********. ************  *

90. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_CP007794 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence) position: , mismatch: 10, identity: 0.688

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
cgcgaggccggggcggtctgcgtcgccggcaa	Protospacer
.* . **********.** *********    

91. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 10, identity: 0.688

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
caactggccgaggcgatcgacgtcgccgctgc	Protospacer
... .*****.********.*********  .

92. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_CP006369 (Aureimonas sp. AU20 plasmid pAU20b, complete sequence) position: , mismatch: 10, identity: 0.688

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
ccggaagccgaggcgagcggcgtcgccgccga	Protospacer
. *. .****.***** ************   

93. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_CP032322 (Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence) position: , mismatch: 10, identity: 0.688

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
cgcgaggccggggcggtctgcgtcgccggcaa	Protospacer
.* . **********.** *********    

94. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_CP013503 (Rhizobium esperanzae strain N561 plasmid pRspN561c, complete sequence) position: , mismatch: 10, identity: 0.688

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gtcatggccgtggtgatcggcgtcgccgtcgg	Protospacer
   *.***** **.**************.   

95. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_CP013509 (Rhizobium sp. N1341 plasmid pRspN1341d, complete sequence) position: , mismatch: 10, identity: 0.688

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gtcatggccgtggtgatcggcgtcgccgtcgg	Protospacer
   *.***** **.**************.   

96. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_CP013520 (Rhizobium sp. N113 plasmid pRspN113c, complete sequence) position: , mismatch: 10, identity: 0.688

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gtcatggccgtggtgatcggcgtcgccgtcgg	Protospacer
   *.***** **.**************.   

97. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_CP013493 (Rhizobium sp. N6212 plasmid pRspN6212c, complete sequence) position: , mismatch: 10, identity: 0.688

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gtcatggccgtggtgatcggcgtcgccgtcgg	Protospacer
   *.***** **.**************.   

98. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_CP013516 (Rhizobium sp. N1314 plasmid pRspN1314e, complete sequence) position: , mismatch: 10, identity: 0.688

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
gtcatggccgtggtgatcggcgtcgccgtcgg	Protospacer
   *.***** **.**************.   

99. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_CP032340 (Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence) position: , mismatch: 10, identity: 0.688

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
cgcgaggccggggcggtctgcgtcgccggcaa	Protospacer
.* . **********.** *********    

100. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_CP012915 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence) position: , mismatch: 10, identity: 0.688

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
cgcgaggccggggcggtctgcgtcgccggcaa	Protospacer
.* . **********.** *********    

101. spacer 2.4|898255|32|NC_016113|CRT matches to NZ_LR134460 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 18, complete sequence) position: , mismatch: 11, identity: 0.656

tggacggccggggcgatcggcgtcgccgcgct	CRISPR spacer
aacctcgccgaggcgatcgccgtcgccgccga	Protospacer
 .  . ****.******** *********