CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_016796	Brucella canis HSK A52141 chromosome 2, complete sequence	1 crisprs	cas3,DEDDh,csa3	0	0	0	0
NC_016778	Brucella canis HSK A52141 chromosome 1, complete sequence	1 crisprs	csa3,WYL	0	0	3	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_016796_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016796_1

616130-616230

Orphan

Consensus_repeat	Method
GGGCGGCATGGACTTCTAAGAAGTCCAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_016796_1

>merge|NC_016796|1|616130-616230|CRISPRCasFinder
GGGCGGCATGGACTTCTAAGAAGTCCATAAAGCTCGCCCATGAACTAAATGCCTGCGCCGCAAAGCGGCGCGGGGGCGGCATGGACTTCCAAGAAGTCCAT

>NC_016796|1|1|616130-616230|CRISPRCasFinder
GGGCGGCATGGACTTCTAAGAAGTCCAT	AAAGCTCGCCCATGAACTAAATGCCTGCGCCGCAAAGCGGCGCGG
GGGCGGCATGGACTTCCAAGAAGTCCAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_016796.1\|WP_002966383.1\|611714_612704_-\|bifunctional-riboflavin-kinase/FAD-synthetase	unknown	unknown	gnl\|CDD\|235536
NC_016796.1\|WP_002967189.1\|624982_625639_-\|DNA-3-methyladenine-glycosylase-I	unknown	unknown	gnl\|CDD\|377025
NC_016796.1\|WP_006133636.1\|608452_611371_-\|isoleucine--tRNA-ligase	unknown	unknown	gnl\|CDD\|237514
NC_016796.1\|WP_002966391.1\|618798_619200_+\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|225168
NC_016796.1\|WP_002966390.1\|617304_618696_+\|class-II-fumarate-hydratase	unknown	unknown	gnl\|CDD\|234779
NC_016796.1\|WP_002966398.1\|625878_626613_+\|L,D-transpeptidase	unknown	unknown	gnl\|CDD\|224294
NC_016796.1\|WP_014315905.1\|604271_606017_-\|pseudouridine-synthase	unknown	unknown	gnl\|CDD\|224108
NC_016796.1\|WP_002966377.1\|603727_604291_-\|16S-rRNA-(guanine(966)-N(2))-methyltransferase-RsmD	unknown	unknown	gnl\|CDD\|223813
NC_016796.1\|WP_004690023.1\|606684_607245_-\|cytochrome-b	unknown	unknown	gnl\|CDD\|225580
NC_016796.1\|WP_005971898.1\|621488_622619_-\|ATP-phosphoribosyltransferase-regulatory-subunit	unknown	unknown	gnl\|CDD\|183413
NC_016796.1\|WP_004692520.1\|602097_603642_-\|insulinase-family-protein	unknown	unknown	gnl\|CDD\|223685
NC_016796.1\|WP_002966386.1\|614120_614417_+\|co-chaperone-GroES	unknown	unknown	gnl\|CDD\|178988
NC_016796.1\|WP_002971287.1\|607589_608261_-\|hypothetical-protein	unknown	unknown	unknown
NC_016796.1\|WP_004692532.1\|626888_627716_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381357
NC_016796.1\|WP_004690018.1\|620796_621492_-\|ATP-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|237438
NC_016796.1\|WP_006015192.1\|616900_617155_+\|hypothetical-protein	unknown	unknown	unknown
NC_016796.1\|WP_006073322.1\|612791_613640_-\|TIGR01459-family-HAD-type-hydrolase	unknown	unknown	gnl\|CDD\|319827
NC_016796.1\|WP_006133639.1\|606157_606631_+\|nucleoside-deaminase	unknown	unknown	gnl\|CDD\|223663
NC_016796.1\|WP_004690017.1\|622627_624136_-\|histidine--tRNA-ligase	unknown	unknown	gnl\|CDD\|223202
NC_016796.1\|WP_004681424.1\|624246_624864_-\|LysE-family-translocator	unknown	unknown	gnl\|CDD\|224199

Protein	Function_ID	Function_description	E-value
NC_016796.1\|WP_002966383.1\|611714_612704_-\|bifunctional-riboflavin-kinase/FAD-synthetase	gnl\|CDD\|235536	PRK05627, PRK05627, bifunctional riboflavin kinase/FAD synthetase.	2.77791e-157
NC_016796.1\|WP_002967189.1\|624982_625639_-\|DNA-3-methyladenine-glycosylase-I	gnl\|CDD\|377025	pfam03352, Adenine_glyco, Methyladenine glycosylase. The DNA-3-methyladenine glycosylase I is constitutively expressed and is specific for the alkylated 3-methyladenine DNA.	3.88001e-109
NC_016796.1\|WP_006133636.1\|608452_611371_-\|isoleucine--tRNA-ligase	gnl\|CDD\|237514	PRK13804, ileS, isoleucyl-tRNA synthetase; Provisional.	0
NC_016796.1\|WP_002966391.1\|618798_619200_+\|DoxX-family-protein	gnl\|CDD\|225168	COG2259, COG2259, Predicted membrane protein [Function unknown].	2.4232e-20
NC_016796.1\|WP_002966390.1\|617304_618696_+\|class-II-fumarate-hydratase	gnl\|CDD\|234779	PRK00485, fumC, fumarate hydratase; Reviewed.	0
NC_016796.1\|WP_002966398.1\|625878_626613_+\|L,D-transpeptidase	gnl\|CDD\|224294	COG1376, ErfK, Uncharacterized protein conserved in bacteria [Function unknown].	1.69228e-59
NC_016796.1\|WP_014315905.1\|604271_606017_-\|pseudouridine-synthase	gnl\|CDD\|224108	COG1187, RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis].	4.94723e-82
NC_016796.1\|WP_002966377.1\|603727_604291_-\|16S-rRNA-(guanine(966)-N(2))-methyltransferase-RsmD	gnl\|CDD\|223813	COG0742, COG0742, N6-adenine-specific methylase [DNA replication, recombination, and repair].	1.21532e-78
NC_016796.1\|WP_004690023.1\|606684_607245_-\|cytochrome-b	gnl\|CDD\|225580	COG3038, CybB, Cytochrome B561 [Energy production and conversion].	1.46443e-52
NC_016796.1\|WP_005971898.1\|621488_622619_-\|ATP-phosphoribosyltransferase-regulatory-subunit	gnl\|CDD\|183413	PRK12295, hisZ, ATP phosphoribosyltransferase regulatory subunit; Provisional.	1.01993e-156
NC_016796.1\|WP_004692520.1\|602097_603642_-\|insulinase-family-protein	gnl\|CDD\|223685	COG0612, PqqL, Predicted Zn-dependent peptidases [General function prediction only].	1.49669e-117
NC_016796.1\|WP_002966386.1\|614120_614417_+\|co-chaperone-GroES	gnl\|CDD\|178988	PRK00364, groES, co-chaperonin GroES; Reviewed.	5.80408e-54
NC_016796.1\|WP_004692532.1\|626888_627716_+\|aldo/keto-reductase	gnl\|CDD\|381357	cd19131, AKR_AKR5C2, Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins. Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.	8.73712e-178
NC_016796.1\|WP_004690018.1\|620796_621492_-\|ATP-phosphoribosyltransferase	gnl\|CDD\|237438	PRK13583, hisG, ATP phosphoribosyltransferase.	1.83362e-134
NC_016796.1\|WP_004690017.1\|622627_624136_-\|histidine--tRNA-ligase	gnl\|CDD\|223202	COG0124, HisS, Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis].	6.87005e-159
NC_016796.1\|WP_006073322.1\|612791_613640_-\|TIGR01459-family-HAD-type-hydrolase	gnl\|CDD\|319827	cd07525, HAD_like, uncharacterized family of the haloacid dehalogenase-like (HAD) hydrolase superfamily. The haloacid dehalogenase-like (HAD) hydrolases are a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members include 2-L-haloalkanoic acid dehalogenase (C-Cl bond hydrolysis), azetidine hydrolase (C-N bond hydrolysis); phosphonoacetaldehyde hydrolase (C-P bond hydrolysis), phosphoserine phosphatase and phosphomannomutase (CO-P bond hydrolysis), P-type ATPases (PO-P bond hydrolysis) and many others. Members are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	6.96029e-90
NC_016796.1\|WP_006133639.1\|606157_606631_+\|nucleoside-deaminase	gnl\|CDD\|223663	COG0590, CumB, Cytosine/adenosine deaminases [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis].	3.78119e-64
NC_016796.1\|WP_004681424.1\|624246_624864_-\|LysE-family-translocator	gnl\|CDD\|224199	COG1280, RhtB, Putative threonine efflux protein [Amino acid transport and metabolism].	1.14786e-45

>NC_016796.1|WP_002966386.1|614120_614417_+|co-chaperone-GroES
MADIKFRPLHDRVVVRRVESEAKTAGGIIIPDTAKEKPQEGEVVAAGAGARDEAGKLVPLDVKAGDRVLFGKWSGTEVKIGGEDLLIMKESDILGIVG
>NC_016796.1|WP_006073322.1|612791_613640_-|TIGR01459-family-HAD-type-hydrolase
MILPERLDDLTDRYDAIFCDVWGVVHNGETSFAPAIAALQRARAKGVTIILVTNSPRPHPGVVAQMSLLGVPENAYDRVVTSGDVTRDLIAEGPRRIFHIGCERELAIYDGLDVELVEEFEAAGVVCTGLYDDEVETPEDYRELLQRLRSRNLPFICANPDIMVERGPRLIWCAGALAREYGQLGGRTLIAGKPHRPIYEAALRAVESIRGGSVDKSRILGIGDGVLTDVKGAADFGLDVLYISGGVHAADYAVNGDLDMAKMEAFLEKHGHRPIASLHALV
>NC_016796.1|WP_002966383.1|611714_612704_-|bifunctional-riboflavin-kinase/FAD-synthetase
MKKSSFQRLTGTEGLPPALHDCVVAIGNFDGVHRGHQAVLERALELAERESRPAVVLTFEPHPRSFFKQDQPVDRLTDAAEKAEILRLMGFDAVMEQPFTAEFSQRSAEDFVQHILVEKLRASRVVTGYDFHFGKGRRGTPEFLCEAGKKAGFSVTLVDAFTDEGGMLVSSTRIRNLLSEGEVAEAAGLLGYRYRICGEVIHGKKLGRTLGFPTANMALAPQTSLKHGIYAVRFRLDDAMLYDGVASFGRRPTVDDEGAPLLETFLFDFSGDLYGKTAAVSFFGFLRGEVKFDGLDPLIDQMKQDEAQARALLADVRPISGLDRMLSFN
>NC_016796.1|WP_006133636.1|608452_611371_-|isoleucine--tRNA-ligase
MTDTTKIDYSKTLYLPQTEFPIRAGLPQREPLFVQRWEEMNLYKKLREQAKDRPLYVLHDGPPYANGNIHIGHALNKILKDVITRSFQMRGYNSNYVPGWDCHGLPIEWKIEEKYRAAGKNKDEVPINEFRKECREFASNWIKVQTEEFKRLAILGDFENPYTTMNFHAEARIAGELLKFAASGQLYRGSKPVMWSVVERTALAEAEVEYHDIESDMIWVKFPVAGEVATENDLSGSAVVIWTTTPWTIPGNRAVSYSSRIEYGLFEITEAENDFGPRPGERLVFADKLVEECCAKAKLQFKRLRSVSAEELGKIVLDHPLKGFGGGYEFVVPMLDGDHVTDDAGTGFVHTAPSHGREDFEAWMDNARQLEARGIDPNIPFPVGDDGFYTKDAPGFGPDREGGPARVIDDNGKKGDANKVVIEQLIAADKLFARGRLKHSYPHSWRSKKPVIFRNTPQWFVYMDKNLGDGTTLRSRALKAIDETRFVPAAGQTRLRSMIEGRPDWVLSRQRAWGVPICVFVDEEGNILQDDAVNKRIMDAFEKEGADAWFADGARERFLGARAGEGWTQVRDILDVWFDSGSTHTFTLEDRPDLKWPADVYLEGSDQHRGWFHSSLLESCGTRGRAPYNAVVTHGFTMDEHGKKMSKSLGNTVTPQDVIKESGADILRLWVMTTDYWEDQRLGKSIIQTNIDAYRKLRNTIRWMLGTLTHDEGENVAYADLPELERLMLHRLTELDELVRSGYDTFDFKRIARALVDFMNVELSAFYFDIRKDALYCDAPSSIRRKAALQTVREIFVRLTTWLAPMLPFTMEEAWLDRYPQSVSIHAEQFRPTPAEWRDDVLAEKWRKVRAVRRVVTGALELERADKRIGSSLEAAPVVYIADKSLSDSLEGLDFAEICITSGISVSDAAAPEGAFTLGDVKGVAVVPERAKGEKCARSWRYTTDVGADPEFPEVSARDAAALRELQALGKL
>NC_016796.1|WP_002971287.1|607589_608261_-|hypothetical-protein
MKIEGRVLVLMTALAGLSLSGCVSSPTYGTDKSAGAQLLDDVSNMASFGQGKKKERIDYKPRPDLVRPAPGDKGYLPAPQQSLASSSDPNWPESPEQRRKRVRDEITAHRDDPNYVSPVLQDAPVADNIRTALPRGNSRREDYASRTPTSDPAKVAALKAARAQQNQGSATTRRYLSEPPLAYRQPASTAAVGELGPDEAQKERERKKAASGSRGWRDYLPWN
>NC_016796.1|WP_004690023.1|606684_607245_-|cytochrome-b
MSSKTYIWDDRSGYGLVSRGFHWLMALLFLWQFASAILRVFAKDTPIYSFFWSAHFQLGFALLVLALLRGVWGLMNIHRRPHKDGAIGKLAVLGHLAIYVLMITIPSLALLRAYGSGCGFSFLGMPIFAKTDIQNAMLTAPANALHGPLGWVLLAAIVGHVAMALVHHFALRDDTLRYMTGHGTPN
>NC_016796.1|WP_006133639.1|606157_606631_+|nucleoside-deaminase
MRKAASITKANSATPMDIALEEAHAAGERGEVPIGAVIVRDGEIIARAGNRTREFNDVTAHAEILTIRQAGEMLGSERLIDCDLYVTLEPCAMCAAAISFARIRHLYYGASDPKGGGIEHGGRFYTQPTCHHAPEIYPGFCEADARKILKDFFREKR
>NC_016796.1|WP_014315905.1|604271_606017_-|pseudouridine-synthase
MMAQGDAVTLLKGLYQMTTEDDNKGGKPPHGRKGHSDRPGRPDRDSRPRREGGDRDKPRKFGSRGAPVEEETSERIAKRLARAGIASRREAETMIATGRIAVNGKVLESPAVNVKRTDIITVDGKPLRQTERTRLWLYHKPAGLVTTNRDPEGRPTVFEALPPEMPRVLSVGRLDINTEGLLLLTNDGGLSRVLELPSTGWLRRYRVRAHGKVTQQQLDELKNGIAVDGVFYGSVEAELERVQGANVWISIGLREGKNREVKNILGALGLTVGRLIRVSFGPFQLGDLEEGAVREIKGRTLRDQLGDKLIEESGADFDAPVLNEFSNAAVQGRTRREMEEGELPQEGERRRAPREREWISSTGERRRGREEKTEKVEPRRRGNANVWMAPGARPKGEKEAAKPARVEHQQPHRSAKFSGDLQMRPRRFSEEERGGEESGERRYKRPEGRFEREGGRPDNREKYEKHEGAGKERRPGKRERAELRNAEGQTTERGKGGFEGRKPGKPGGPRSEGRFGGADRDTRSGPRGSGPRGAGDGPRRGHDGKPGGKPGGKPTGRPGGKPGTKPGGGGRSGGGGADRRR
>NC_016796.1|WP_002966377.1|603727_604291_-|16S-rRNA-(guanine(966)-N(2))-methyltransferase-RsmD
MRIVGGKFRGRALVTPSTNAIRPTTDRTRESLFNILAHSFPDKVEGVRVLDLFAGTGALGLEALSRGARYATFVEESAEGRGILRQNIEALGLQGHTKILRRDACQLGIVGTMEPFDLVFADPPYGRRMGEKAFLSALQGGWLNPDALLVLEEDAQAALELDDRFAVREERNYGGTVIRLIELKAAS
>NC_016796.1|WP_004692520.1|602097_603642_-|insulinase-family-protein
MNNPSLRRLLLSTVLGFALALPLAGGAVRAEMQPAAPAETQPAPAAPAAPVAQAALPEISRLDGVSNFTLPNGMQVVVIPDHRAPVVTQMVWYHVGAADEAPGVSGIAHFLEHLMFKGTKNHPAGEFSARIASIGGQENAFTSYDYTAYFQRVSPEALEMVMDFESDRMENLVLDEEAVKTEREVILEERRMRIDSNPGAMLMENTDAVLFYNHPYRKPVIGWQQEMEKLSLKNAIDFYNQYYTPNNATLVIAGDVTPERVRELAMKTWANVHKRAEVLLRERPQEPAKHAARVVTLHDERVSTPSFRISWLVPSYANEKRFANVKPGDAPALDLLSEILGGSQLSRLYQQLIVKQGIAAETGASYDGDALDDGTFSVYGVPRNGASLGDVEKAVAAQVDRIIRDGVTQAELDQARNRFLKAVIFARDSQTGMARIYGSALSVGQTVDDIQKWPDLIKSVTVDQIKDVVRRYLVKDQAVTSYLLPPDTEAESARKKPNAPANDASASGAGGAIQ
>NC_016796.1|WP_006015192.1|616900_617155_+|hypothetical-protein
MRKELPIETAPKDGRKITVIWIDDDDQRNESIAQYRTLEQLRAGGGQWDEADTGWWTFTDSKTQRKIEPTAWIRETDDDESQED
>NC_016796.1|WP_002966390.1|617304_618696_+|class-II-fumarate-hydratase
MAATRTETDTFGPIDVPADRYWGAQTQRSLQNFRIGGERMPLPLVHALGVVKRAAAETNIALGKLDPVLGQVIAVAASEVIEGKLDDHFPLVVWQTGSGTQSNMNANEVISNRAIELLGGEMGSKKPIHPNDHVNMSQSSNDSFPTAIHIATAVETVNRLYPALEHLTKALKVKEEAFKDIIKIGRTHTQDATPVTLGQEFSGYRAALEYARHRLEQSLADVFLLAQGGTAVGTGLNAPVGFDKGFAEAVSEITGLSFKTAPNKFEALASHGAVLNFHGSLNALAADLFKIANDIRFLGSGPRSGLGELSLPENEPGSSIMPGKVNPTQAEAMTMVATQVFGNQTAVTVAASQGHFELNVFKPVIAYNVLQSIRLLSDTMVSFADHCVEGIEPNTARIKELLERSLMLVTALAPAIGYDNAARIAKTAHKNGTTLREEALASGLVSEEDYDRLVRAERMIAPQ
>NC_016796.1|WP_002966391.1|618798_619200_+|DoxX-family-protein
MSSITPKANGAATLIIRVFLSVLFIIAGYNKLTALDGTADYFASIGLPMPIVTAVVVGLIEFVGGLAILFGFKTRIAAVIVGLFTLGATLVAHMDFAEGMNLLIAQKNLAIAGGLFLLFLHGAGSLSIDARRG
>NC_016796.1|WP_004690018.1|620796_621492_-|ATP-phosphoribosyltransferase
MSVTLALPSKGRLKEKTLAVLEKAGYKVVLPDDDRNYRARVEGEDDLDILFLSASEIARELGYGSVDLGVTGEDLARETLAHADERVAIEAQLGFGHADVVVAVPEVWRDVTTMADLDDVAADFRQRHGRRLRIATKYWRLTQQFFSQKHGIQVYRIVESLGATEGAPAAGSADMIVDITSTGSTLRANRLKVLEDGIILRSQACLVSARRSHTSRRVEEIAARIRAGLEI
>NC_016796.1|WP_005971898.1|621488_622619_-|ATP-phosphoribosyltransferase-regulatory-subunit
MVGSRTSPIFNALRVELNAREAELVEIPLIQPADPFLDMAGEDLRRRIFLTENENGDSLCLRPEFTIPVCRNHIALNAATPKRYAYLGEVFRQRRDGAAEFLQAGIEDLGAADEAASDARSLADALSCVKAIAPDAPLEIVLGDQSVFAGMLKALGLPQGWRKKLLRSFGDAHSMDLALAELTGTQRRDPLPESLAVLVAEGDEIGLARMLEAEMLEAGISPGAGRTPVEIARRLIEKEDLAATHFPAAALDLLRQFLAIRVSLDTAAVTLRAFAADNALDLGAVLQKFEARADAIAQAGIEMKDIIYDASFGRPLDYYTGLVYEIRDASNRQDGVLAGGGRYDRLLTMLGACEAIPGVGFSIWLDRLQALAGEKQ
>NC_016796.1|WP_004690017.1|622627_624136_-|histidine--tRNA-ligase
MADKADKMKARLPRGFVDRVPDDLRAAEKMMATIREVYDLYGFEPVETPLVEYTDALGKFLPDQDRPNEGVFSFQDDDEQWLSLRYDLTAPLARYVAENFETLPKPYRSYRNGWVFRNEKPGPGRFRQFMQFDADTVGAPNVSADAEMCMMMADTLERLGIQRGDYAIRVNNRKVLDGVLDAIGLEGEGNAAKRLNVLRAIDKLDKFGPEGVRLLLGKGRLDESGDFTKGAQLPEAAIEKVLAFTAAGGADGAQTIANLQAVVAGNAEGEEGVQELADMQALFFAGGYEGRVKIDPSVVRGLEYYTGPVFEAELLFDVTNEDGQKVVFGSVGGGGRYDGLVSRFRGEPVPATGFSIGVSRLMTALKNLGKLDVSDTVGPVVVLVMDKDTQNLGRYQKMVSDLRKAGIRAEMYVGGSGMKAQMKYADRRAAPCVVIQGSQEREAGEVQIKDLVEGKRLSAEIEDNVTWRESRPAQITVREDGLVDAVREILDAQARDRAEQSK
>NC_016796.1|WP_004681424.1|624246_624864_-|LysE-family-translocator
MDLMSLVAFAGILVVAAGTPGPNVGALVARVISRGHKGVFPFMFGLWLGDAVWLSLAVWGLSALAHTFQTAFLVLKYAGVAYLIYLSWKMWFAPVDEEADENTIPRQGEGKRLFLSALGVTLGNPKIMVFYLAILPTVVDITHVSLTGWVELLLVMFMVLAAVDTAWVVLAAQARKFLRSPRMMRLANRTSAGMMAGAAVAIAAR
>NC_016796.1|WP_002967189.1|624982_625639_-|DNA-3-methyladenine-glycosylase-I
MSDMAEARAGLVVGADGRTRCFWPGELPDYLAYHDNEWGVPVADDFRLFEKICLEGFQSGLSWLTILRKRENFRAAFDGFNFHRIATYDESDVERLLADKGIVRHRGKIVSVINNAGRAIELIEEKGSLAAYFWSFEPGAENRPAVVDYPTLVANPITATSTRISKDLKKRGWSFVGPTTVYAFMQAMGLVNDHIEGCHCRATIEKLRQNFKRPGKKL
>NC_016796.1|WP_002966398.1|625878_626613_+|L,D-transpeptidase
MKPRHLLLIGSLTAIAVSIVSTGMAFADDRYSDLPPVRVSQAISAPWVAQLQDAPARPRIARQETRKTKTHYNKVSYQRPATNPATTARKKQFDPIYLPQIVSYSGKEKPGTIVIDTASRFLYLVQADGKARRYGVGVGKQGFSWKGTQRISRKAEWPTWTPPSEMIARERKKGRFLPARMDGGINNPLGARALYLGSTLYRIHGTNQPWTIGKAMSSGCIRMRNEDVTDLYERTPVGTRVVVR
>NC_016796.1|WP_004692532.1|626888_627716_+|aldo/keto-reductase
MTVPTVKLNDGNHIPQLGYGVWQISNDEAVSAVSEALKAGYRHIDTATIYGNEKGVGKAINGSGIARADIFLTTKLWNSDQGYESTLKAFDTSLKKLGTDYVDLYLIHWPMPSKDLFMETWRAFIKLKEEGRVKSIGVSNFRTADLERLIKESGVTPVLNQIELHPQFQQDELRLFHGKHDIATEAWSPLGQGKLLEDPTLKSIAEKHAKSVAQIILRWHIETGNIVIPKSITPARIKENFDIFDFTLNGTDHDAITKLDMADGRIGPNPSVFSA

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

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CRISPR-Cas detection and classification

Crispr_ID: NC_016778_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016778_1

414997-415081

Orphan

Consensus_repeat	Method
CCGAACACCGCTTCGCACTTTTCGGGATGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_016778_1

>merge|NC_016778|1|414997-415081|CRISPRCasFinder
CCGAACACCGCTTCGCACTTTTCGGGATGCAGATCTTTCCTTGCGCGCATCTTATCCGAAAACCGCTTCGCACTTTTCGGGATGC

>NC_016778|1|1|414997-415081|CRISPRCasFinder
CCGAACACCGCTTCGCACTTTTCGGGATGC	AGATCTTTCCTTGCGCGCATCTTAT
CCGAAAACCGCTTCGCACTTTTCGGGATGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_016778.1\|WP_004690698.1\|413677_414253_+\|NYN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350235
NC_016778.1\|WP_004689567.1\|425488_426622_+\|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl\|CDD\|181255
NC_016778.1\|WP_006132439.1\|420894_421983_-\|porin	unknown	unknown	gnl\|CDD\|308243
NC_016778.1\|WP_006132438.1\|422822_423926_+\|porin	unknown	unknown	gnl\|CDD\|308243
NC_016778.1\|WP_002963786.1\|420109_420751_-\|hypothetical-protein	unknown	unknown	unknown
NC_016778.1\|WP_004690699.1\|412879_413281_-\|DNA-directed-RNA-polymerase-subunit-omega	unknown	unknown	gnl\|CDD\|234744
NC_016778.1\|WP_006132452.1\|404742_405525_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380379
NC_016778.1\|WP_004691929.1\|409800_410379_-\|orotate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|273579
NC_016778.1\|WP_002971509.1\|419135_419792_-\|endonuclease	unknown	unknown	gnl\|CDD\|237082
NC_016778.1\|WP_002966733.1\|404117_404693_-\|DUF2062-domain-containing-protein	unknown	unknown	gnl\|CDD\|225757
NC_016778.1\|WP_002963803.1\|403716_404121_-\|holo-ACP-synthase	unknown	unknown	gnl\|CDD\|234610
NC_016778.1\|WP_002963792.1\|414283_414955_+\|uracil-DNA-glycosylase	unknown	unknown	gnl\|CDD\|381681
NC_016778.1\|WP_004690694.1\|417015_419073_+\|lytic-transglycosylase-domain-containing-protein	unknown	unknown	gnl\|CDD\|381604
NC_016778.1\|WP_006132450.1\|405776_406988_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341031
NC_016778.1\|WP_006132442.1\|410386_412639_-\|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	unknown	unknown	gnl\|CDD\|223394
NC_016778.1\|WP_002963791.1\|415091_415568_-\|SsrA-binding-protein-SmpB	unknown	unknown	gnl\|CDD\|235455
NC_016778.1\|WP_002967515.1\|424199_425126_+\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271177
NC_016778.1\|WP_004690695.1\|415658_416540_-\|4-hydroxy-tetrahydrodipicolinate-synthase	unknown	unknown	gnl\|CDD\|235107
NC_016778.1\|WP_002963787.1\|419871_420054_-\|hypothetical-protein	unknown	unknown	unknown
NC_016778.1\|WP_006132444.1\|408885_409641_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|236494

Protein	Function_ID	Function_description	E-value
NC_016778.1\|WP_004690698.1\|413677_414253_+\|NYN-domain-containing-protein	gnl\|CDD\|350235	cd10911, PIN_LabA, PIN domain of Synechococcus elongatus LabA (low-amplitude and bright) and related proteins. This subfamily contains Synechococcus elongatus PCC 7942 LabA which participates in cyanobacterial circadian timing, it is required for negative feedback regulation of the autokinase/autophosphatase KaiC, a central component of the circadian clock system, and appears to be necessary for KaiC-dependent repression of gene expression. This subfamily belongs to the LabA-like domain family which includes the N-terminal domain of limkain b1, a human autoantigen localized to a subset of ABCD3 and PXF marked peroxisomes. Also included in the LabA-like domain family are human ZNF451, uncharacterized Bacillus subtilis YqxD, uncharacterized Escherichia coli YaiI, and the N-terminal domain of a well-conserved group of mainly bacterial proteins with no defined function, which contain a C-terminal LabA_like_C domain. Curiously Pseudomonas putida S16 NicB , which is described as a putative NADH-dependent hydroxylase involved in the microbial degradation of nicotine also falls into the LabA-like family. The PIN (PilT N terminus) domain belongs to a large nuclease superfamily. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	5.09849e-62
NC_016778.1\|WP_004689567.1\|425488_426622_+\|pyridoxal-phosphate-dependent-aminotransferase	gnl\|CDD\|181255	PRK08153, PRK08153, pyridoxal phosphate-dependent aminotransferase.	0
NC_016778.1\|WP_006132439.1\|420894_421983_-\|porin	gnl\|CDD\|308243	pfam02530, Porin_2, Porin subfamily. This family consists of porins from the alpha subdivision of Proteobacteria the members of this family are related to pfam00267. The porins form large aqueous channels in the cell membrane allowing the selective entry of hydrophilic compounds this so called 'molecular sieve' is found in the cell walls of gram negative bacteria.	1.52358e-117
NC_016778.1\|WP_006132438.1\|422822_423926_+\|porin	gnl\|CDD\|308243	pfam02530, Porin_2, Porin subfamily. This family consists of porins from the alpha subdivision of Proteobacteria the members of this family are related to pfam00267. The porins form large aqueous channels in the cell membrane allowing the selective entry of hydrophilic compounds this so called 'molecular sieve' is found in the cell walls of gram negative bacteria.	4.24975e-104
NC_016778.1\|WP_004690699.1\|412879_413281_-\|DNA-directed-RNA-polymerase-subunit-omega	gnl\|CDD\|234744	PRK00392, rpoZ, DNA-directed RNA polymerase subunit omega; Reviewed.	7.28537e-25
NC_016778.1\|WP_006132452.1\|404742_405525_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|380379	cd06124, cupin_NimR-like_N, AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain. This family contains mostly bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators. Included in this family is Escherichia coli HTH-type transcriptional regulator NimR (also called YeaM) that negatively regulates expression of the nimT operon and its own expression. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	2.86834e-33
NC_016778.1\|WP_004691929.1\|409800_410379_-\|orotate-phosphoribosyltransferase	gnl\|CDD\|273579	TIGR01367, Orotate_phosphoribosyltransferase, orotate phosphoribosyltransferase, Thermus family. This model represents a distinct clade of orotate phosphoribosyltransferases. Members include the experimentally determined example from Thermus aquaticus and additional examples from Caulobacter crescentus, Helicobacter pylori, Mesorhizobium loti, and related species. [Purines, pyrimidines, nucleosides, and nucleotides, Pyrimidine ribonucleotide biosynthesis].	6.9538e-76
NC_016778.1\|WP_002971509.1\|419135_419792_-\|endonuclease	gnl\|CDD\|237082	PRK12373, PRK12373, NADH-quinone oxidoreductase subunit E.	2.3845e-28
NC_016778.1\|WP_002966733.1\|404117_404693_-\|DUF2062-domain-containing-protein	gnl\|CDD\|225757	COG3216, COG3216, Uncharacterized protein conserved in bacteria [Function unknown].	5.43979e-83
NC_016778.1\|WP_002963803.1\|403716_404121_-\|holo-ACP-synthase	gnl\|CDD\|234610	PRK00070, acpS, 4'-phosphopantetheinyl transferase; Provisional.	7.50792e-67
NC_016778.1\|WP_002963792.1\|414283_414955_+\|uracil-DNA-glycosylase	gnl\|CDD\|381681	cd10031, UDG-F5_TTUDGB_like, Uracil DNA glycosylase family 5, includes Thermotoga maritima TTUDGB and similar proteins. Uracil DNA glycosylase family 5 includes Thermus thermophilus HB8 TTUDGB (also called UDGb) which is not only a UDG acting on double-stranded uracil-containing DNA, but also a hypoxanthine DNA glycosylase acting on double-stranded hypoxanthine-containing DNA (except for the C/I base pair), as well as a xanthine DNA glycosylase acting on both, double-stranded and single-stranded xanthine-containing DNA. TTUDGB also excises thymine from G:T mismatched DNA, and removes analogs of uracil from DNA, including 5-hydroxymethyluracil (hmU) and 5-fluorouracil (fU). This subfamily also contains Bradyrhizobium diazoefficiens family 5 homolog Blr5068 (UdgB) which has been found to efficiently excise uracil from ssDNA and dsDNA. Uracil-DNA glycosylases (UDGs) initiate repair of uracils in DNA. Similar to family 4 UDGs, members of this family possess four conserved cysteine residues required to coordinate the [4Fe-4S] iron-sulfur cluster. Uracil in DNA can arise as a result of mis-incorporation of dUMP residues by DNA polymerase or via deamination of cytosine. Uracil in DNA mispaired with guanine is one of the major pro-mutagenic events, causing G:C->A:T mutations. Thus, UDG is an essential enzyme for maintaining the integrity of genetic information. UDGs have been classified into various families on the basis of their substrate specificity, conserved motifs, and structural similarities. Although these families demonstrate different substrate specificities, often the function of one enzyme can be complemented by the other.	7.75632e-104
NC_016778.1\|WP_004690694.1\|417015_419073_+\|lytic-transglycosylase-domain-containing-protein	gnl\|CDD\|381604	cd13401, Slt70-like, 70kDa soluble lytic transglycosylase (Slt70) and similar proteins. Catalytic domain of the 70kda soluble lytic transglycosylase (LT)-like proteins, which also have an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.	2.26681e-60
NC_016778.1\|WP_006132450.1\|405776_406988_+\|MFS-transporter	gnl\|CDD\|341031	cd17478, MFS_FsR, Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters. Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.33918e-106
NC_016778.1\|WP_006132442.1\|410386_412639_-\|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	gnl\|CDD\|223394	COG0317, SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription].	0
NC_016778.1\|WP_002963791.1\|415091_415568_-\|SsrA-binding-protein-SmpB	gnl\|CDD\|235455	PRK05422, smpB, SsrA-binding protein SmpB.	1.57135e-88
NC_016778.1\|WP_002967515.1\|424199_425126_+\|site-specific-integrase	gnl\|CDD\|271177	cd00796, INT_Rci_Hp1_C, Shufflon-specific DNA recombinase Rci and Bacteriophage Hp1_like integrase, C-terminal catalytic domain. Rci protein is a tyrosine recombinase specifically involved in Shufflon type of DNA rearrangement in bacteria. The shufflon of plasmid R64 consists of four invertible DNA segments which are separated and flanked by seven 19-bp repeat sequences. RCI recombinase facilitates the site-specific recombination between any inverted repeats results in an inversion of the DNA segment(s) either independently or in groups. HP1 integrase promotes site-specific recombination of the HP1 genome into that of Haemophilus influenza. Bacteriophage Hp1_like integrases are tyrosine based site specific recombinases. They belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	1.4048e-42
NC_016778.1\|WP_004690695.1\|415658_416540_-\|4-hydroxy-tetrahydrodipicolinate-synthase	gnl\|CDD\|235107	PRK03170, PRK03170, dihydrodipicolinate synthase; Provisional.	8.83567e-177
NC_016778.1\|WP_006132444.1\|408885_409641_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|236494	PRK09391, fixK, transcriptional regulator FixK; Provisional.	4.33719e-50

>NC_016778.1|WP_002963792.1|414283_414955_+|uracil-DNA-glycosylase
MISEPSPNCSICPRLHAFLQEWRQKEPAWHNAPVPPFLPGSDEDVRLLIVGLAPGLRGANRTGRPFTGDYAGELLYSTLCEFGFATGKFEARPDDSLRLLDACIVNAVRCVPPENKPVGSEINNCRQFLTPMLTRFPNLDAVVTLGTIAHQSTVRALGVPVSRHPFGHGKATDIGPLRIFSSYHCSRYNTNTGVLTDAMFRDVFKNVRAYLSEKAAGSARLSV
>NC_016778.1|WP_004690698.1|413677_414253_+|NYN-domain-containing-protein
MFDSREKIALFINGANLYAASKTLGFDIDYRKLLKAFQKRGYLLRAYYYTALVEDQEYSSIRPLIDWLDYNGYKVVTKAAKEFTDSTGRRKVKGNMDIELTVDAMQLTDTVDHFVIFSGDGDFRSLVEALQRKGRKVSVVSTLTTQPAMISDELRRQADHFIDLVSLKAEIGRDPSERAPRRQEEDFDESY
>NC_016778.1|WP_004690699.1|412879_413281_-|DNA-directed-RNA-polymerase-subunit-omega
MARVTVEDCVDKVENRFELVLLAGHRARQISQGVPITVDRDNDKNPVVALREIADETLSPDDLKEDLIHSLQKHVEVDEPEAAPAQIANAAEEIAEGIAEAGEEDVVTFDRMSEEELLAGIEGLVAPEKNDGF
>NC_016778.1|WP_006132442.1|410386_412639_-|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase
MMRQYELVERVQRYKPDVNEALLNKAYVYAMQKHGSQKRASGDPYFSHPLEVAAILTDMHLDEATIAIALLHDTIEDTTATRQEIDQLFGPEIGKLVEGLTKLKKLDLVSKKAVQAENLRKLLLAISEDVRVLLVKLADRLHNMRTLGVMCEDKRLRIAEETMDIYAPLAGRMGMQDMREELEELAFRYINPDAWRAVTDRLAELLEKNRGLLQKIETDLSEIFEKNGIKASVKSRQKKPWSVFRKMETKGLSFEQLSDIFGFRVMVDTVQDCYRALGLIHTTWSMVPGRFKDYISTPKQNDYRSIHTTIIGPSRQRIELQIRTREMDEIAEFGVAAHSIYKDRGSANNPHKISTETNAYAWLRQTIEQLSEGDNPEEFLEHTKLELFQDQVFCFTPKGRLIALPRGATPIDFAYAVHTDIGDSCVGAKVNGRIMPLMTELKNGDEVDIIRSKAQVPPAAWESLVATGKARAAIRRATRSAVRKQYSGLGMRILERAFERAGKPFSKDILKPGLPRLARKDVEDVLAAVGRGELPSTDVVKAVYPDYQDTRVTTKNNPAKAGEKGWFNIQNAAGMIFKVPEGGEGAAAKVDPAATTPKPGKRALPIRGTNPDLPVRFAPEGAVPGDRIVGILQPGAGITIYPIQSPALTAYDDQPERWIDVRWDIDDQMSERFPARISVSAINSPGSLAKIAQIAAANDANIHNLSMVRTAPDFTEMIIDVEVWDLKHLNRIISQLKESASVSSAKRVNG
>NC_016778.1|WP_004691929.1|409800_410379_-|orotate-phosphoribosyltransferase
MNTDDVLAVFREAGAILEGHFILTSGLRSPVFLQKARVFMHADKTEKLCKALAEKIRAADLGPIDYVVGPAIGGLIPSYETSRHLGVPSVWVERENGVFRLRRFDVPKGARVVIVEDIVTTGLSIRETIDCMKDLGIEVVAAACIVDRSAGKADVGTRLISLAAYEVPAYPADKLPPELAAIPAVKPGSRNI
>NC_016778.1|WP_006132444.1|408885_409641_-|helix-turn-helix-domain-containing-protein
MVVVPFALDQNQKLAARTPCKVCEDCCVRSMAVCSALDDGDLAALEAIMTSKKLDTNEMLVEEGEPELRVYSLTSGMLRIYTSLPDGRRQIAGFLFPGDFLGLADDEVYSQSAEAVVPSALCAFSAKEMERLMERFPKLKERLYQMTRLALRTARDNQLVLGRLAPVEKLASFLLVLSARAEKRGEKPNPVHLLMNRTDIADYLGLTIETVSRSFTKLKTQGLIQLRGANTVEILSRRSLAVVAGLDPDNL
>NC_016778.1|WP_006132450.1|405776_406988_+|MFS-transporter
MSVSAAQQPSNSSADNTVLTIILATSLGHFLNDMMQSLLPAIYPMLKENYSLSFWQIGLLTFTFQMTASILQPLVGIYTDRKPMPYSLTFGMGCTLIGLVFLATAHHYSFLLLGAACVGFGSSVFHPEAARVARLASGGRHGFAQSLFQVGGNFGSSIGPLLAAFIVLPFGQISVSWFSVAALIGMFVLWYVGNWYNRYRLANASKPKPDKTLPLPRNRVIAPVAVLALLVFTKYIYMAILTSYYTFYTISHFGVSVQTSQLLLFLFLGAVAAGTIIGGPIGDKISARKVIWASILGVLPFTLALPYANLEMTAVLTIIIGLILASAFPAIIVFAQELLPGRVGMVSGLFFGFAFGMAGIAAAVLGIVADQKGIEFVYRICSYLPFLGLLTIFLPKLERRRKA
>NC_016778.1|WP_006132452.1|404742_405525_-|helix-turn-helix-transcriptional-regulator
MPENEDLQRFHERRIAMLESMTGPAIALPTRYPDGYFVPRHSHSRAQLLCASQGVVLVTTDAGRWMIPSDHAMWIPAGVEHSVAILGDVFMRSIYISVDAISGVPNYLHVVGLTDLMRCLIIDATSHDSIPAPEYPLGLPFPSDPRLQKLCRDFVKKPSSRATIDEWADRMAMSRRSFTRHFQRETGVSLSVWRQQACLFAAVPRLSEGEPVTSVALDLGYDSVSAFTTMFRRMLGVPPKFYQPRLDVAPSERSDKAAFG
>NC_016778.1|WP_002966733.1|404117_404693_-|DUF2062-domain-containing-protein
MLFQRRYPPTRWERLRLYLWPRRSFSRSFRYGGKRILRITASPHAVAAGLAVGVFSAFTPFFGFHLIIAIVLAYFLAGNVAAAALGTTLANPLTLPFIWGSTFELGRFIMSGSVDSVPPVHLGHALETMRFEEVWTPLLKPMLFGSTILGAAFAVLVYFVTRYAVSVFRRRRLERLAEKHRLHRQRELQKA
>NC_016778.1|WP_002963803.1|403716_404121_-|holo-ACP-synthase
MIVGIGSDLIDIRRVEKTLERHGSRFRDRVFTEIEQRKSEGRKQRAASYAKRFAAKEACAKALGTGIAEGVFWRDMGVVNTPSGKPTMHLTGGAAKQLQKLLPAGTNAAIHLTITDDFPLAQAFVIIEALPVLE
>NC_016778.1|WP_002963791.1|415091_415568_-|SsrA-binding-protein-SmpB
MNKPKNSPARKMIAENRKARFNFEILDTLEAGLVLTGTEVKSLRANQANIAESYASFEDGEFWLINSYIPEYTQGNRFNHEPRRLRKLLVSRREMSRLFNSVSREGMTVVPLKLYFNDRGRAKLELALARGKKTHDKRETEKKRDWNREKARLLRDRG
>NC_016778.1|WP_004690695.1|415658_416540_-|4-hydroxy-tetrahydrodipicolinate-synthase
MLKGSITALVTPFDREGAFDEKAFRAFVNWQIEEGTKGLVPVGTTGETPTLSHDEHKRVIEVCIEVAAGRVPVIAGAGSNNTVEAIELAQHAEKAGADAVLVVTPYYNKPNQRGLYEHFSRVVRSISIPLVIYNIPGRSIIDMTPETMGALVRDCKNIVGVKDATGKIERVSEQRAICGKEFIQLSGEDATALGFNAHGGVGCISVTSNIAPRLCAEFQEACQAGNFAKALELQDRLMPLHKALFLEPNPSGPKYALSRLGRIENVLRSPMVTIEAATAEKIDHAMKHAGLIN
>NC_016778.1|WP_004690694.1|417015_419073_+|lytic-transglycosylase-domain-containing-protein
MVSLAQSSLPPEIPTPLARPFAPTTTHQSPISLVTPRPRPIAPDPMATSAVSRTDNPAVIGGTLKNGLDALSAKNVASAIASRNNLPRGSLDRQILTWAIATSGMDGVPSTEIAAAASELSGWPGMATLRRNSERALFKENPSSATIIATFGSTRPQTTEGMIALARAYVATGNSTKAHQLLSPWWTRKRLSSDDEQKILKEFSAILTREDHQRRLLHSLYNGRLQSARLLAGPAQAQSLYNAYAAVAQKSPNAASAIAAVDRSWQANPVYQFLKIRYLRRAERYNEAAELLLKAPRKASVLVDPDAWWVERRILSRELLDLGKPQLAYRLAAAHAAETPTMAAEAEFHAGWYALRALNQPKLAAPHFAKITQISARPISASRAYYWLGRAAEAGSGGDARAYYRRSAHFGTTFYGQLAAAKLNEKAPELAYPKPTEAERVRFASRPAVQAIKRLEQVGYGNKAAALYTQLSQELDSVGELALLAVMAERNDNHYMALRVGKTAAMRGLDVGALSHPLGAIPASANIKGSGKALAYAIARQESEFNVSAVSKAGARGLLQLMPATAKTVATRNGMSFSAQKLTADAAYNATLGAHFLGEQLDRFNGSYVLTFAGYNAGPRRASEWVEKYGDPRGKSVEQVVDWIERIPYSETRNYVQRVMENYEVYKTRLTGRADIKTDLVYGRR
>NC_016778.1|WP_002971509.1|419135_419792_-|endonuclease
MPLLIVQLAILIAVAFVVGCFLGRILRRRKSAGSDHERTIVAAALSTPPLAEKPEPVPPAEPVRADSDPLKRKAGLEKARIEPVEGSADSDVAAAPVLQKVPAETPDDAGRPQWREAPRRGKADELTAIEGIGKAIEAVLHELGIFHYDQIAQWTREEAIWIERRIGFPGRVEREGWIAQAAKLAEPPAKSTTKRGAKTKKAANNVRSGTRRAKKQAG
>NC_016778.1|WP_002963787.1|419871_420054_-|hypothetical-protein
MTVFPIRPFLCYDYSAKGLKCLAKYYAESLMLYLVETFWPVLVLAILIGAATGWLTAGER
>NC_016778.1|WP_002963786.1|420109_420751_-|hypothetical-protein
MKKWFWPCLTWTACLTALALWFGADRVETDIAEQTAKALEPYVWAGFYVDGRDVVLKGMAPDPDMQRAAHAALEHVWAIRDITDLTTVLQLASPYRFKIGRNAQGLVLSGFIPNNESRDQVMTAAGEVAPDIFIDDEMAVARGNQPEFMERVLFAIDLAKKLPEAEIEIVDEKLSIRGTVSDEAIYDEIEALKAAQLPYGLKLAVLDVKKSVQ
>NC_016778.1|WP_006132439.1|420894_421983_-|porin
MNIKSLLLGSAAALVAASGAQAADAIVAPEPEAVEYVRVCDAYGAGYFYIPGTETCLRVHGYVRYDVKGGDDVYTGSDRKGWDKSARFALRVSTGSETELGTLKTFTELRFNYAANNSGVDGKYGNETSSGTVMEFAYIQLGGLRVGIDESEFHTFTGYLGDVINDDVISAGSYRTGKISYTFTGGNGFSAVIALEQGGDNDGGYTGTTNYHIDGYMPDVVGGLKYAGGWGSIAGVVAYDSVIEEWAAKVRGDVNITDQFSVWLQGAYSSAATPDQNYGQWGGDWAVWGGLKYQATQKAAFNLQAAHDDWGKTAVTANVAYELVPGFTVTPEVSYTKFGGEWKNTVAEDNAWGGIVRFQRSF
>NC_016778.1|WP_006132438.1|422822_423926_+|porin
MNIKSLLLGSAAALVAASGAQAADAIVAPEPEAVEYVRVCDAYGAGYFYIPGTETCLRVHGYVRYDVKGGDDVYTGSDRKGWDKGARFALMFNTNSETELGTLGTYTQLRFNYTSNNSRHDGQYGDFSDDRDVADGGVSTGTDLQFAYITLGGFKVGIDESEFHTFTGYLGDVINDDVVAAGSYRTGKIAYTFTGGNGFSAVIALEQGGEDVDNDYTIDGYMPHVVGGLKYAGGWGSIAGAVAYDPVIEEWATKVRGDVNITDRFSVWLQGAYSSAATPNQNYGQWGGDWAVWGGAKFIATEKATFNLQAAHDDWGKTAVTANVAYQLVPGFTITPEVSYTKFGGEWKDTVAEDNAWGGIVRFQRSF
>NC_016778.1|WP_002967515.1|424199_425126_+|site-specific-integrase
MIIVGETKIDTGDKYAPIIDYNLNYISGKNPKHRLVEHYSVAELTAKYINILWDDGSHKYNVRSFLGEIDEILKGARFSGFDQEMLDSIIGTLRERGNSNATINRKMAALSKLLRKAHKMGDIFNLPEFIRQKERVGRIRFLEQEEEKRLFAAIKSRCEDSYRLSVFLVDTGCRLGEAIGLTWNDIQEQRVTFWVTKSNRSRTVPLTRRARKASHIPRERLKGPFSMLNQVRFRQIWNEAKAEVGLGADDQIVPHILRHTCASRLVRGGIDIRRVQMWLGHQTLQMTMRYAHLATHDLDSCVKVLEIH
>NC_016778.1|WP_004689567.1|425488_426622_+|pyridoxal-phosphate-dependent-aminotransferase
MAQPRLTPLVESLPSTVPFIGPETLELQRGKPFKARIGANESSFGPAPSVIEAMRNEATEVWKYGDPENYALRHAIAAHHGLKAEHIMPGAGVDALLGLIVRQYVQQGDKVINSLGGYPTFNYHVAGYGGQLVTVPYRDDKPDLDALIDAAAREKPALLYIANPDNPMGTWHEGADIQSFIERLPETTLLILDEAYCETAPASAFPPFETDRPNVLRMRTFSKAYGLAGIRCGYAVGNPVAIKTFDKVRDHFAVSRMAQAAAIAALKDQAYLHEVVGKICAGRDRIAAIAEANGLHAVASATNFVAIDCGRGKDFAQAVLNGLISRDIFVRKPGTPVLDRCIRVSVGVKEQLDQFEAAFPEALEEARKICAANAENT

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

107058 : 115410

Brucella_phage(33.33%)

transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_004689673.1\|107058_108705_-	hypothetical protein	A0A141GEY6	Brucella_phage	1.3e-175	62.0
WP_006132649.1\|108839_109613_-	hypothetical protein	A0A141GEY5	Brucella_phage	2.9e-122	97.3
WP_080723468.1\|109613_110371_-\|transposase	IS5-like element IS711 family transposase	A0A0N9SJT9	Paenibacillus_phage	1.8e-15	40.2
WP_004688321.1\|111211_111457_+	BrnT family toxin	NA	NA	NA	NA
WP_002964097.1\|111456_111771_+	BrnA antitoxin family protein	K4NZP3	Burkholderia_phage	6.9e-06	43.4
WP_002964095.1\|112118_112289_+	DUF1508 domain-containing protein	A0A2P1N580	Mycobacterium_phage	3.1e-05	45.1
WP_004683738.1\|113581_114169_-	hypothetical protein	NA	NA	NA	NA
WP_002964092.1\|114191_114467_-	hypothetical protein	NA	NA	NA	NA
WP_002964091.1\|114463_114694_-	hypothetical protein	NA	NA	NA	NA
WP_006072696.1\|114690_115410_-	hypothetical protein	A0A076GD06	Sinorhizobium_phage	4.6e-05	46.8

DBSCAN-SWA_2

188886 : 200813

uncultured_Mediterranean_phage(90.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012219638.1\|188886_191214_-	protein translocase subunit SecDF	A0A1B1IVP7	uncultured_Mediterranean_phage	4.0e-50	43.1
WP_002964021.1\|191332_191674_-	preprotein translocase subunit YajC	A0A1B1IVR5	uncultured_Mediterranean_phage	9.1e-12	40.2
WP_004691896.1\|191833_192700_+	ATP-binding protein	NA	NA	NA	NA
WP_004690785.1\|192748_194047_-	peptidoglycan DD-metalloendopeptidase family protein	Q8SBN9	Clostridium_phage	1.0e-18	41.1
WP_002964018.1\|194095_194281_-	hypothetical protein	NA	NA	NA	NA
WP_004683704.1\|194425_195094_-	protein-L-isoaspartate(D-aspartate) O-methyltransferase	A0A1B1IU40	uncultured_Mediterranean_phage	6.6e-14	38.5
WP_004683703.1\|195090_195858_-	5'/3'-nucleotidase SurE	A0A1B1ITZ2	uncultured_Mediterranean_phage	1.0e-39	40.2
WP_004690784.1\|196006_197290_-\|tRNA	serine--tRNA ligase	A0A1B1IVT2	uncultured_Mediterranean_phage	3.5e-104	47.0
WP_004690783.1\|197366_198191_-	twin-arginine translocase subunit TatC	A0A1B1IVR7	uncultured_Mediterranean_phage	1.7e-43	40.7
WP_004686803.1\|198187_198769_-	twin-arginine translocase subunit TatB	NA	NA	NA	NA
WP_002964012.1\|198879_199098_-	twin-arginine translocase TatA/TatE family subunit	A0A1B1IVR9	uncultured_Mediterranean_phage	1.5e-07	65.1
WP_004690782.1\|199243_199969_-	SMC-Scp complex subunit ScpB	A0A1B1IVT7	uncultured_Mediterranean_phage	1.1e-43	45.7
WP_002968731.1\|199961_200813_-	segregation/condensation protein A	A0A1B1IVW1	uncultured_Mediterranean_phage	4.4e-31	33.5

DBSCAN-SWA_3

424199 : 531579

102

Hokovirus(10.0%)

protease,holin,tail,capsid,integrase,head,portal,transposase

attL 419710:419726|attR 506194:506210

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
419710:419726	attL	NA	NA	NA	NA
WP_002967515.1\|424199_425126_+\|integrase	site-specific integrase	A0A076YL28	Mesorhizobium_phage	2.9e-28	36.3
WP_004689567.1\|425488_426622_+	pyridoxal phosphate-dependent aminotransferase	A0A1X7QHI1	Faustovirus	1.8e-16	24.2
WP_002963781.1\|426639_427014_+	DUF423 domain-containing protein	NA	NA	NA	NA
WP_002963780.1\|427058_427709_-	hypothetical protein	NA	NA	NA	NA
WP_004683355.1\|428365_429136_+	YitT family protein	NA	NA	NA	NA
WP_004683353.1\|429195_429453_-	sel1 repeat family protein	NA	NA	NA	NA
WP_004686532.1\|429722_429962_+	hypothetical protein	NA	NA	NA	NA
WP_002963776.1\|429958_430306_+	DUF2147 domain-containing protein	NA	NA	NA	NA
WP_004690690.1\|430364_431075_-	glutathione S-transferase N-terminal domain-containing protein	NA	NA	NA	NA
WP_002971518.1\|431269_431437_+	hypothetical protein	NA	NA	NA	NA
WP_002966730.1\|431433_431601_+	hypothetical protein	NA	NA	NA	NA
WP_004691933.1\|431641_433144_+	AMP nucleosidase	NA	NA	NA	NA
WP_006132437.1\|433196_434273_+	endonuclease/exonuclease/phosphatase family protein	NA	NA	NA	NA
WP_004691935.1\|434388_436080_-	electron transfer flavoprotein-ubiquinone oxidoreductase	NA	NA	NA	NA
WP_002963769.1\|436468_437341_+	uracil-DNA glycosylase	NA	NA	NA	NA
WP_006132435.1\|437502_438759_+	MFS transporter	NA	NA	NA	NA
WP_002963767.1\|438763_439723_-	DMT family transporter	NA	NA	NA	NA
WP_004690683.1\|439948_442600_+	aminopeptidase N	NA	NA	NA	NA
WP_002963765.1\|442990_445342_+	PAS-domain containing protein	A0A1V0SGX0	Hokovirus	6.3e-27	34.8
WP_004690682.1\|445612_447724_+	O-antigen ligase family protein	NA	NA	NA	NA
WP_014299901.1\|447768_450720_-	bifunctional [glutamine synthetase] adenylyltransferase/[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase	NA	NA	NA	NA
WP_004690680.1\|450842_452249_-	HAMP domain-containing histidine kinase	NA	NA	NA	NA
WP_002963761.1\|452245_452953_-	response regulator transcription factor	NA	NA	NA	NA
WP_002963760.1\|453046_454588_-\|protease	DegQ family serine endoprotease	A0A1B1IT49	uncultured_Mediterranean_phage	1.7e-28	29.8
WP_004689556.1\|454729_455206_-	cytochrome c-type biogenesis protein CcmH	NA	NA	NA	NA
WP_004690679.1\|455202_457194_-	heme lyase CcmF/NrfE family subunit	NA	NA	NA	NA
WP_004690678.1\|457213_457711_-	cytochrome c maturation protein CcmE	NA	NA	NA	NA
WP_006132431.1\|457707_458847_-	c-type cytochrome biogenesis protein CcmI	NA	NA	NA	NA
WP_002971524.1\|458947_459400_-	hypothetical protein	NA	NA	NA	NA
WP_006132429.1\|459493_460804_-	hypothetical protein	NA	NA	NA	NA
WP_004690676.1\|460878_461568_-	response regulator transcription factor	NA	NA	NA	NA
WP_002971526.1\|461646_461943_-	hypothetical protein	NA	NA	NA	NA
WP_002969445.1\|462104_462311_-	hypothetical protein	NA	NA	NA	NA
WP_004683307.1\|466234_466669_-	C40 family peptidase	NA	NA	NA	NA
WP_006132423.1\|466665_467541_-	DUF2163 domain-containing protein	A0A0K1Y6Z2	Rhodobacter_phage	1.0e-46	38.7
WP_002963747.1\|467537_468170_-	TIGR02217 family protein	A0A0B5A2K3	Paracoccus_phage	2.9e-48	47.6
WP_006132409.1\|468172_468718_-\|tail	phage tail tape measure protein	A0A0S2SYD9	Pseudomonas_phage	2.8e-07	46.4
WP_002963745.1\|468722_468893_-\|tail	phage tail assembly chaperone	NA	NA	NA	NA
WP_004688130.1\|468936_469278_-	gene transfer agent family protein	NA	NA	NA	NA
WP_004689550.1\|469274_469688_-\|tail	phage major tail protein, TP901-1 family	NA	NA	NA	NA
WP_006072374.1\|469728_470136_-	DUF3168 domain-containing protein	NA	NA	NA	NA
WP_004690671.1\|470095_470263_-	hypothetical protein	NA	NA	NA	NA
WP_004688127.1\|470259_470598_-\|head	phage head closure protein	NA	NA	NA	NA
WP_002963740.1\|470594_471161_-\|head,tail	phage head-tail connector protein	NA	NA	NA	NA
WP_004688126.1\|471325_472600_-\|capsid	phage major capsid protein	Q8HAD2	Salmonella_phage	1.7e-82	43.4
WP_002963738.1\|472621_473290_-\|head,protease	HK97 family phage prohead protease	A0A2H4JAI0	uncultured_Caudovirales_phage	1.7e-30	41.1
WP_002967499.1\|473276_473654_-	hypothetical protein	NA	NA	NA	NA
WP_004691941.1\|473650_474844_-\|portal	phage portal protein	W8ECU7	Geobacillus_phage	1.8e-67	40.3
WP_005969588.1\|474875_476135_-	DNA-packaging protein	A0A1V0DY66	Dinoroseobacter_phage	1.3e-71	40.6
WP_002963734.1\|476073_476586_-	hypothetical protein	NA	NA	NA	NA
WP_006132405.1\|476925_479100_+	penicillin-binding protein 1A	NA	NA	NA	NA
WP_004690668.1\|479106_479718_+	DUF1214 domain-containing protein	NA	NA	NA	NA
WP_002963731.1\|479710_480253_+	hypothetical protein	NA	NA	NA	NA
WP_006132402.1\|480450_481527_+	DUF2336 domain-containing protein	NA	NA	NA	NA
WP_004690667.1\|481537_481885_-	DUF1491 family protein	NA	NA	NA	NA
WP_002971535.1\|481898_482867_-	peptidoglycan-binding protein	NA	NA	NA	NA
WP_004691943.1\|482841_484671_-	HAMP domain-containing histidine kinase	W8CYF6	Bacillus_phage	7.3e-23	29.3
WP_004688118.1\|484961_485411_+	hypothetical protein	NA	NA	NA	NA
WP_002963725.1\|485490_485916_+	SufE family protein	NA	NA	NA	NA
WP_002967494.1\|485956_487294_-	amidase	NA	NA	NA	NA
WP_002969449.1\|487384_488179_-	hypothetical protein	NA	NA	NA	NA
WP_004690665.1\|488175_488631_-	hypothetical protein	NA	NA	NA	NA
WP_002969861.1\|488811_489123_+	hypothetical protein	NA	NA	NA	NA
WP_004688116.1\|489330_489759_-	MucR family transcriptional regulator	A0A1P8VVG0	Erythrobacter_phage	1.0e-20	47.6
WP_004690662.1\|490330_492439_+	S9 family peptidase	NA	NA	NA	NA
WP_002963717.1\|492556_492892_+	hypothetical protein	NA	NA	NA	NA
WP_004690660.1\|493063_493663_-	superoxide dismutase	Q56AR7	Bacillus_thuringiensis_phage	1.8e-39	43.1
WP_002963715.1\|493885_494539_+	haloacid dehalogenase type II	NA	NA	NA	NA
WP_006132398.1\|494540_494783_-	hypothetical protein	NA	NA	NA	NA
WP_002963714.1\|494841_495558_+	L,D-transpeptidase	NA	NA	NA	NA
WP_004690659.1\|495755_497267_-	DUF853 domain-containing protein	A0A248XCZ8	Klebsiella_phage	1.4e-83	44.3
WP_002963712.1\|497602_497965_+	hypothetical protein	NA	NA	NA	NA
WP_004691944.1\|498021_499332_-	CynX/NimT family MFS transporter	NA	NA	NA	NA
WP_002963710.1\|499328_500006_-	FadR family transcriptional regulator	NA	NA	NA	NA
WP_002963709.1\|500161_501154_+	magnesium transporter CorA family protein	NA	NA	NA	NA
WP_002963708.1\|501214_501445_+	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	NA	NA	NA	NA
WP_004690657.1\|501441_501831_+	type II toxin-antitoxin system death-on-curing family toxin	A0A1B3AYM0	Gordonia_phage	2.6e-07	34.9
WP_004690656.1\|501827_502298_-	GreA/GreB family elongation factor	NA	NA	NA	NA
WP_002963705.1\|502342_503365_-	asparaginase	NA	NA	NA	NA
WP_004690655.1\|503555_504152_+	transcriptional regulator BetI	NA	NA	NA	NA
WP_004691946.1\|504154_505804_+\|holin	choline dehydrogenase	A0A1V0S9M4	Catovirus	8.5e-63	32.5
WP_004690653.1\|505989_507453_+	betaine-aldehyde dehydrogenase	NA	NA	NA	NA
506194:506210	attR	NA	NA	NA	NA
WP_017403480.1\|508021_509062_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_004688104.1\|509323_510355_+	LacI family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_004690651.1\|510387_511839_+	xylulokinase	NA	NA	NA	NA
WP_004691947.1\|511885_513193_+	xylose isomerase	NA	NA	NA	NA
WP_004691948.1\|513234_514407_-	Gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
WP_004688100.1\|514414_515467_-	sugar phosphate isomerase/epimerase	NA	NA	NA	NA
WP_004691949.1\|515524_516487_-	substrate-binding domain-containing protein	NA	NA	NA	NA
WP_002967480.1\|516565_517567_-	ABC transporter permease	NA	NA	NA	NA
WP_006132391.1\|517587_519156_-	sugar ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	1.8e-14	24.9
WP_109790518.1\|519262_519466_-	hypothetical protein	NA	NA	NA	NA
WP_002969456.1\|519814_520924_-	glycosyltransferase family 4 protein	NA	NA	NA	NA
WP_004690648.1\|521006_522179_-	AGE family epimerase/isomerase	NA	NA	NA	NA
WP_002963689.1\|522211_523636_-	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase	A0A1V0SH58	Hokovirus	9.0e-53	30.8
WP_004690647.1\|523660_525064_-	phosphomannomutase	NA	NA	NA	NA
WP_006132388.1\|525674_525992_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_098944111.1\|525888_526652_-\|transposase	IS5 family transposase	A0A0N9SHJ4	Paenibacillus_phage	8.0e-24	42.5
WP_006072314.1\|526816_527371_+\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_077281774.1\|527413_527566_+	hypothetical protein	NA	NA	NA	NA
WP_002963682.1\|528322_529441_-	glycosyltransferase family 4 protein	NA	NA	NA	NA
WP_029097245.1\|530640_531579_-\|transposase	IS481 family transposase	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_016796

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NC_016778

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection