CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_016935	Paenibacillus mucilaginosus 3016, complete sequence	22 crisprs	WYL,cas3,csa3,RT,DEDDh,DinG	3	13	4	0

1. NC_016935

CRISPR-Cas detection and classification

Crispr_ID: NC_016935_1

• CRISPR_ID: NC_016935_1
• CRISPR_location: 395275-395461
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 3 spacers

Consensus repeat of NC_016935_1

Consensus_repeat	Method
AGCATGCGATGCAAAACATCGCAT	CRT

spacers of NC_016935_1

>1.1|395299|27|NC_016935|CRT
AACCGCCGGCTTGATGCTCAATCGTCC
>1.2|395350|37|NC_016935|CRT
GCTGAGGCCCAGGACGTCATTTGCCGCATTCGCTGCG
>1.3|395411|27|NC_016935|CRT
AACCGCCGGCCTGACGCTCCACAGCCC

CRISPR arrays and Neighbor proteins around NC_016935_1

CRISPR arrays

The CRISPR arrays of NC_016935_1

>merge|NC_016935|1|395275-395461|CRT
AGCATGCGATGCAAAACATCGCATAACCGCCGGCTTGATGCTCAATCGTCCAGCATGTGATAAAAAACATCACATGCTGAGGCCCAGGACGTCATTTGCCGCATTCGCTGCGGTCATACGATGCAAAACATCGCATAACCGCCGGCCTGACGCTCCACAGCCCAGCATGCGATGCAAAACATCGTAT

>NC_016935|1|1|395275-395461|CRT
AGCATGCGATGCAAAACATCGCAT	AACCGCCGGCTTGATGCTCAATCGTCC
AGCATGTGATAAAAAACATCACAT	GCTGAGGCCCAGGACGTCATTTGCCGCATTCGCTGCG
GTCATACGATGCAAAACATCGCAT	AACCGCCGGCCTGACGCTCCACAGCCC
AGCATGCGATGCAAAACATCGTAT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016935.1|WP_041616462.1|396137_396392_-|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_013914175.1|388435_388765_-|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl|CDD|225209
NC_016935.1|WP_014368229.1|380024_385265_+|Ig-like-domain-repeat-protein	unknown	unknown	gnl|CDD|379864
NC_016935.1|WP_014368232.1|387749_388391_-|methyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|369777
NC_016935.1|WP_187296716.1|386134_387175_+|NADH:flavin-oxidoreductase	unknown	unknown	gnl|CDD|240095
NC_016935.1|WP_014368241.1|409117_409960_+|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_014368233.1|389956_390850_+|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl|CDD|223472
NC_016935.1|WP_013914176.1|388981_389944_+|sugar-ABC-transporter-permease	unknown	unknown	gnl|CDD|226666
NC_016935.1|WP_014368236.1|396678_404874_+|S-layer-homology-domain-containing-protein	unknown	unknown	gnl|CDD|223893
NC_016935.1|WP_014368240.1|408368_409118_+|VWA-domain-containing-protein	unknown	unknown	gnl|CDD|238119
NC_016935.1|WP_014368230.1|385526_386108_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228
NC_016935.1|WP_014368242.1|409956_410301_+|EsaB/YukD-family-protein	unknown	unknown	gnl|CDD|378057
NC_016935.1|WP_014368237.1|405299_405791_-|DUF1992-domain-containing-protein	unknown	unknown	unknown
NC_016935.1|WP_014368235.1|392849_395174_+|alpha-xylosidase	unknown	unknown	gnl|CDD|236731
NC_016935.1|WP_014368239.1|407537_408116_+|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_014368234.1|390930_392601_+|extracellular-solute-binding-protein	unknown	unknown	gnl|CDD|270300
NC_016935.1|WP_014368238.1|406023_407289_-|erythromycin-esterase-family-protein	unknown	unknown	gnl|CDD|377470
NC_016935.1|WP_014368243.1|410366_414437_+|type-VII-secretion-protein-EssC	unknown	unknown	gnl|CDD|274860
NC_016935.1|WP_013914191.1|414450_415401_+|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl|CDD|274862
NC_016935.1|WP_148279731.1|387295_387682_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016935.1|WP_013914175.1|388435_388765_-|antibiotic-biosynthesis-monooxygenase	gnl|CDD|225209	COG2329, COG2329, Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only].	1.71676e-16
NC_016935.1|WP_014368229.1|380024_385265_+|Ig-like-domain-repeat-protein	gnl|CDD|379864	pfam16640, Big_3_5, Bacterial Ig-like domain (group 3). This family consists of bacterial domains with an Ig-like fold.	5.04963e-18
NC_016935.1|WP_014368232.1|387749_388391_-|methyltransferase-domain-containing-protein	gnl|CDD|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	1.10832e-24
NC_016935.1|WP_187296716.1|386134_387175_+|NADH:flavin-oxidoreductase	gnl|CDD|240095	cd04747, OYE_like_5_FMN, Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as electron acceptors in the catalytic reaction. Other members of OYE family include trimethylamine dehydrogenase, 2,4-dienoyl-CoA reductase, enoate reductase, pentaerythriol tetranitrate reductase, xenobiotic reductase, and morphinone reductase.	0
NC_016935.1|WP_014368233.1|389956_390850_+|carbohydrate-ABC-transporter-permease	gnl|CDD|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	7.37922e-68
NC_016935.1|WP_013914176.1|388981_389944_+|sugar-ABC-transporter-permease	gnl|CDD|226666	COG4209, LplB, ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism].	1.03651e-136
NC_016935.1|WP_014368236.1|396678_404874_+|S-layer-homology-domain-containing-protein	gnl|CDD|223893	COG0823, TolB, Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion].	5.0983e-14
NC_016935.1|WP_014368240.1|408368_409118_+|VWA-domain-containing-protein	gnl|CDD|238119	cd00198, vWFA, Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.	1.60979e-09
NC_016935.1|WP_014368230.1|385526_386108_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	4.08393e-07
NC_016935.1|WP_014368242.1|409956_410301_+|EsaB/YukD-family-protein	gnl|CDD|378057	pfam08817, YukD, WXG100 protein secretion system (Wss), protein YukD. The YukD protein family members participate in the formation of a translocon required for the secretion of WXG100 proteins (pfam06013) in monoderm bacteria, with the WXG100 protein secretion system (Wss). Like the cytoplasmic protein EsaC in Staphylococcus aureus, YukD was hypothesized to play a role of a chaperone. YukD adopts a ubiquitin-like fold. Usually, ubiquitin covalently binds to protein and flags them for protein degradation, however conjugation assays have indicated that the classical YukD lacks the capacity for covalent bond formation with other proteins. In contrast to the situation in firmicutes, YukD-like proteins in actinobacteria are often fused to a transporter involved in the ESAT-6/ESX/Wss secretion pathway. Members of the YukD family are also associated in gene neighborhoods with other enzymatic members of the ubiquitin signaling and degradation pathway such as the E1, E2 and E3 trienzyme complex that catalyze ubiquitin transfer to substrates, and the JAB family metallopeptidases that are involved in its release. This suggests that a subset of the YukD family in bacteria are conjugated and released from proteins as in the eukaryotic ubiquitin-mediated signaling and degradation pathway.	7.45083e-10
NC_016935.1|WP_014368235.1|392849_395174_+|alpha-xylosidase	gnl|CDD|236731	PRK10658, PRK10658, putative alpha-glucosidase; Provisional.	0
NC_016935.1|WP_014368234.1|390930_392601_+|extracellular-solute-binding-protein	gnl|CDD|270300	cd13582, PBP2_AlgQ_like_3, Periplasmic-binding component of alginate-specific ABC uptake system-like; contains the type 2 periplasmic binding fold. This subgroup includes uncharacterized periplasmic-binding proteins that are closely related to high molecular weight (HMW) alginate bining proteins (AlgQ1 and AlgQ2) found in gram-negative soil bacteria. The HMW alginate uptake system is composed of a novel pit formed on the cell surface and a pit-dependent ATP-binding cassette (ABC) transporter in the inner membrane. The transportation of HMW alginate from the pit to the ABC transporter is mediated by periplasmic HMW alginate-binding proteins (AlgQ1 and AlgQ2). Alginate is an anionic polysaccharide that is made up of alpha-L-mannuronate and its 5'-epimer, alpha-L-guluronate. Alginate is present in the cell walls of brown seaweeds, where it forms a viscous gum by binding water. Alginate is also produced by two bacteria genera Pseudomonas and Azotobacter. AlgQ1 and AlgQ2 belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. However, unlike other bacterial periplasmic-binding proteins that deliver small solutes to ABC transporters, AlgQ1/2 can bind a macromolecule and may have specificity for either sugar or a certain type of polysaccharide.	0
NC_016935.1|WP_014368238.1|406023_407289_-|erythromycin-esterase-family-protein	gnl|CDD|377470	pfam05139, Erythro_esteras, Erythromycin esterase. This family includes erythromycin esterase enzymes that confer resistance to the erythromycin antibiotic.	2.3296e-129
NC_016935.1|WP_014368243.1|410366_414437_+|type-VII-secretion-protein-EssC	gnl|CDD|274860	TIGR03928, T7_EssCb_Firm, type VII secretion protein EssC, C-terminal domain. This model describes the C-terminal domain, or longer subunit, of the Firmicutes type VII secretion protein EssC. This protein (homologous to EccC in Actinobacteria) and the WXG100 target proteins are the only homologous parts of type VII secretion between Firmicutes and Actinobacteria. [Protein fate, Protein and peptide secretion and trafficking].	0
NC_016935.1|WP_013914191.1|414450_415401_+|WXG100-family-type-VII-secretion-target	gnl|CDD|274862	TIGR03930, WXG100_ESAT6, WXG100 family type VII secretion target. Members of this protein family include secretion targets for the two main variants of type VII secretion systems (T7SS), one found in the Actinobacteria, one found in the Firmicutes. This model was derived through iteration from pfam06013. The best characterized member of this family is ESAT-6 from Mycobacterium tuberculosis. Members of this family usually are ~100 amino acids in length but occasionally have a long C-terminal extension.	3.21113e-17
NC_016935.1|WP_148279731.1|387295_387682_-|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.74303e-13

Protein sequences

>NC_016935.1|WP_014368235.1|392849_395174_+|alpha-xylosidase
MKFSDGFWMTREGYQLIPAVQVFSVTAEERSVTVLVAPRDVSRRSGQLDCPLLTIRYYSPQPDVIGVKIEHFAGVQQAGPDFELQRSETHEVTVERGDGVVTLTAGRVSVKVREAGDWSAVFYQDGRRITGSGSKAAAHVSGPDGDVHVKEELDLGVGELIYGLGERFTPFVKNGQTVDIWNRDGGTSSEQAYKNVPFYLSNRGYGVFVNQPELVSFEVASEKVSKVQFSVPGESLEYYVIGGPSGKEVLERYTTLTGKPALPPAWSFGLWLTTSFTTNYDEETVNSFVDGMRERDLPLHVFHFDCFWMKAFHWTDFQWDPEVFPDPAGMLKRLKEKGLHICVWINPYIAQQSRLFAEGRERGYLIKRPNGDVWQWDRWQPGQGIVDFTNPEACEWYAGYLRELVDMGVDSFKTDFGERIPTDVVYHDGSDPQRMHNYYTHLYNKVVFDVLEEKLGRGQAVLFARSATAGGQQFPVHWGGDCFASYESMAESLRGGLSLGLSGFGFWSHDIGGFESTSSADVYKRWTAFGLLSSHSRLHGNVSYRVPWAFDDESVDVMRFFTQWKCRLMPYLFGGAVEASQKGLPLMRAMLLEFGDDPTAGYLDRQYMLGDSVLVAPVFNEEGRISFYLPQGRWTHLFTGETVEGGTWREEEHGYMSLPIYVRPGTLLPVGADASRPDYDYADGVELQLFELADGATAERVVYSTQAAEVLRVSVTRSGGSLSVRAEGESAGAWSLLLRGVDSAGAEGAAAERTPLGVRLTPEAGRREWSVRLA
>NC_016935.1|WP_014368234.1|390930_392601_+|extracellular-solute-binding-protein
MMRRLTKWVSVMLAAALVTVTGCSKEPAAEPGQASGSGTDPITMSVFSADPNPAWNNMQDEVGKKLTEKTGVTLKMEFPVGSSDQKIPLMVSSGEYPDMILPKGDPGKLVAADALLDLTDLIEQHGPNLKKVYGKYMKRLRWSTEDPSIYILPISPVDQEYFDAGGGFELQHAVVKELGYPKIRTVKDFENAIKAYKDKYPTIDGKPTIGLSLNADDWHIMISVTNPAFLTTGAPDDGEYYIDPKTYEAKFHYFRPEEKEYFRWLNHMNNIGLIDPESFVQKYDQYKAKIASGRVLGLIDQDWDYQEAQNVLRKEGKFERTYGHYPVTLNESFKDHSFQDTGYLAGYGIGITKSAKDPVRAIKFLDYLASDEGQVLINWGIEGVHYKVENGMRVIPPDVLDKKVNDANNFAKTSGIGQYYISARYGDGVKDPTGSTYTTTTVEQKIASYSEADKETLKAYGATTWKDLFPKKEEFPVKPWGAAWSIPVEPDSNVNVTYNKAKTIVWKRIPEAILAKPEQFDAIYDGMLQELDKVGVKKMEQEYTELVKERVKLFNE
>NC_016935.1|WP_014368233.1|389956_390850_+|carbohydrate-ABC-transporter-permease
MTWARKSLSDRLFDLVLYAAMIFTVVVTLYPFLNVLAISLNDSTDTVRGGIHIWPREFTLKNYETIFQYSGLMTGFRNSVIRTLAGTLIGVISASMVAYVLSREEFQARRLFSMLFALTMYFSGGLIPVYMLMRDLSLLNSFWVYLIPGLLSVWNVFIIRSYINGLPYALQESAKIDGANDFTIYWRVVLPLCQPVLATVALFIAVGQWNSWFDTYLYNSSNESLTTLQYELMKVLQSTQNNADAARNPNMAQNIAAVSPESIRMAITIVVTLPILLVYPFLQKYFVKGMTLGAVKS
>NC_016935.1|WP_013914176.1|388981_389944_+|sugar-ABC-transporter-permease
MEPLTTRGALPMEKPRRSGGFWQTMGRQKYLYFMSVPFVIWLIVFSYVPIWGWLMAFQKFRPGRSIFEQNWVGLANFAELFADERFYLVLRNTLAMSVMGLVVGFTVPIIFALLMNELKGQFFKRSVQTISYLPHFVSWVVVAGLVTKMLSTEGGAVNSLLLSLGVIDAPVQFMAKGEWFWSIVTASDMWKETGWNSIIYLAAMAGIDPELYEAATVDGAGRFRKIWHITLPGIRPTFMVLLILSIGHLVSIGFEKQFLLGNPLVIDYSEVVDLYALNYGIGLSRYSYGTAIGIFNSVVSIVLVLTANGIYKRLTKESII
>NC_016935.1|WP_013914175.1|388435_388765_-|antibiotic-biosynthesis-monooxygenase
MSDLAKTPQPPYYAVIFTSERTAGDKGYGRMADLMVELASQQPGFLGVESARDAGGLGITVSYWSSLEAIRAWREHALHQTAQEKGRTDWYERYALRVSKVERDAFFEM
>NC_016935.1|WP_014368232.1|387749_388391_-|methyltransferase-domain-containing-protein
MGTFFARHYDALMGWLEKRGFTRIRANLLREASGTVLEIGSGTGLNFPLYHGCDKVVALEPSEVMRRTSMKRALIAPVPVEPVGGDAQNLPFADASFDTVVGTLVLCTIPDPLRALREIRRVCKPGGTVLFFEHVRLEHAALGRLQDWLTPAWKRLCDGCCLNRSTLDTLQQAGLEIKRTERYYGDIFVTVVARNPEAGSGDASASRTGAFES
>NC_016935.1|WP_148279731.1|387295_387682_-|GNAT-family-N-acetyltransferase
MRLNREFNGVVDITAEEVSRSLRLGPELVAVAILDGVLSGFACAQSFTSFCYRERQAEITELFVMETARGQGLARELLLLLEEHLRRQGVQSIKVITGGSNEAALKTYVRSGYIPKEHAVLYKELGSV
>NC_016935.1|WP_187296716.1|386134_387175_+|NADH:flavin-oxidoreductase
MNTNASVQSLFRPFAFGNVTLSSRIVMAPMTRQYSPDGVPGPNVVDYYRRRAENEVGLIVTEGTVVPHPDASNQANIPHFFGEAALNGWAKVVAAVHEAGGRIIPQLWHMGAKGNVGEYTEEEVAAIVEAFAQAASEAKRIGFDGIELHGAHGYLIDQFFWEQTNPRTDRYGGDVVKRTRFAVEVIEACRRAVGPEFPIVLRISQWKPTDYSAKLAGTPALLEQFLAPLSAAGVDVFHCSTRRFWEPEFEGSELNLAGWTKKLTGKPTITVGSVGLDGDFTNLFTNGEGAGNAKVDGLIERLEREEFDLVAVGRALLVDPAWASKLRDGRTDELTPFTPEALKTLV
>NC_016935.1|WP_014368230.1|385526_386108_+|TetR/AcrR-family-transcriptional-regulator
MSRPREFNIECALQQCMEVFWTKGFKATSFEDLTRRTQVKKQSLYCAFDDKRALFLKTLALYREQHAAKMEQFVSQEGSPLQKLEKIRDATFTPSAEGSCRGCFMVNSALEFGISDEEVTRQVEMMFREVERMIEQLIRSGQEQQMITNRHTAEALAAHLTNSLLGARMMEKSGASRERIEAVLRTSFALILP
>NC_016935.1|WP_014368229.1|380024_385265_+|Ig-like-domain-repeat-protein
MNRTLAPNAASAASAAFRLMRWSLFCLWAVLVFLVVPDESAQAATFTVNHTADTVDAAPGNGVCADASDASGKCTLRAAIMESNALPGADTINVGPGVYTLILGGTGENGATTGDLDILGDLVLVGAGGNAEGDPAATVIQAGESSSTGIDRVIDINPNLDLNTNVTIQALTVRYGRGTDEYGAGIAADSGSGTIRIYNSVITNNHNVVAGGNGAGLYLSGGNPAGKLLVDKSRIDGNTSYNRGGGIFVEGVTPFIMTDTTVENNTATAGSGGGLFLIGGGQRTIFSSTIAGNSAIGTAGSSLDGLGGGVYSISKLNLDNSTVSGNAAVKGGGGLQLAYAGEGAYLVRNATIYGNTADSDNNASGSGGGIGVQAGTAAPLLHNTIVAGNRLGSEAASDIFGSAAGGSSYNLIGTGGSGGLVTGAAGNQTGVSDLRLGALADNGGPTKTHALLAGSPALDAGTAAQAPGAADQRGTAFARTADAADADTASAVDIGAFEAHPSVEDLQDVSMAMGGARQIEFHIGDADLGVDTVTAVSSDPQLIPNAAENLAVSGSGGARTLTVKPAPGQSGSATITVTVSHPVGGALRSMTDTFLVTVAPQPDLAITKTHTGNFRKGQPGAYTITVTNVGSASTSGGITIEDWLPAGLTFLSVEAAGWSCEYGQEPTKCTSGKALEPGESFDPIVLTVNVQEDAASTVTNRAVVSGGGDVNLDNNTALDSTVIKSSTSVSLNTSKTPSDYGERVTWTANVSADTGTPIGTVTFKDGSDVLGVASLSSGKAVYSSDSLAVGSHSITAEYNGSADYLGSVSPVVEQAVLSLATKTVVTALPTSSVFGQPVTFTAVVTAAAPASGTPTGTVTFKDGDTDLGTASLDGAGVATLPVNGLIAGTHRITAVYSGSATFAGSVSEGLDYMVERATTTLLKSSVTESVYGEKVTLTAEVKSAGGTPTGEVILHSGSTELGRGALGADGTTVISLIELVPGTYDIIASYSGDGLHAGSVSAPDLTLTVDRAATTTSVLSVSDAVYGESVTLTAEVRVIEPGAGKVGGTVSFLRDGGLLGDAPLDAGGTAVLKDITLPLGTSAITAVYGDGSPLYKGSISSPVEVTVRSPKLELDSYNYTLRLGENHTTVVRAVYGADDLRDVTGQSFFFSSNPSVAEVDAAGKVTAVGFGTANITVVYGSEQAVALVTVPIPNALNSNTALKSLTLTEGMAVLVPGTDTYEATVGSGVGSIGIQAETEDAEALVSINGSTAVEGTASLTADLSEGLNTFDIAVTAPDGSKKQYSLKITRERSSTGGGDGGSDNGGGGDNDGGTGNSGSGQPGETPKPEEPETPEVPWLIPVRPGGTVFVPLAVTVSHNGSTTVVSLSDGAVKDKLDGKKGPKVFLIALPKGAQRSQIEISSGIMALIRSGHQASSVGIAADGASFDLPVRLFTPDALAKALGISAADAEKARILITVTAKAAPAGVDAASARLYDFSIVVEAGGRTYPYDQYKGSYLAKAFGLKPSADVKKAAGITITGEATAYPVPFEKAEVEGSPVLVLKADHNGTFGIITQQRSFTDTDGTWAQDAIEGLSGRLVVDGYPDGSFRPEVPVSRSEFAAMLARALGWVPDSSASVQYTDVDPAAWDAGYIASMSERGLISGYEDGSFRGSQRITREEAAVLLTRALAYVQTEAQSAGAGTGSTAAFADSGEVSSYAREAIAKAQAQGLLSGYEDDTFKPQGLTNRAETVTLISKLLQLTGLAGS
>NC_016935.1|WP_041616462.1|396137_396392_-|hypothetical-protein
MIPKECESINVKIQELNAQKKELQADLPGLAGAQKWALLQQISALQHKITTLKNELNSCILRGGGKLPLKATFNAAFTLRTSYP
>NC_016935.1|WP_014368236.1|396678_404874_+|S-layer-homology-domain-containing-protein
MKRKRSKLWKRGTALLLATTMVLGDLGAAAAVGPEEFDPASVITADTIMDAVYGPEGGIAVPPPVPPAPQPILVPQPVAAGEPLSWNLLTKVDRSKIPSIYFPEDQVLKMSADGRYIGFKRFELVTEEPAHVNKVITVYDRKTGAMDDIQSPPNHSQNDEVIYFDMSSDARYVAFSYMSYTEDWKEKTKVYLFDRETRNLTPITTVEGSTDSHEGTDRVAISADGRYVAFDSDAPGIVAEDTDDLRDVFVYDRESGATQRITAFPEMGEYDYGDSEAPTISADGRYIAFHSDSKFVEKDTYGQTNVYVYDREDSNARPQLVSIGVGGAAGEGHSTLPSISADGSVIAYESTAENMVSGDFNEMKDIFVYNRNTAVTQRVSLAEGGIPFNRDSMSPSISRDGRYVGFHLDYVWVEDTDDDHDNDDENDIPEEAYVAEVASQTAYPVTVPQAPYRLLNPSQSPIVGDGGKLVVYLSEYFYSYTGGSEGTPFPGTFIAEKGTAPVWPAGSKLEPSNRTGDSVTLSWPDAVDATGILGYHVYQDGKNIGYVEYRGTGSNTFTAEGLLPVYEPEFQVEAVNSAYRESYGGPTYKLGAGGGENPAGELRVLWDVEDMRYNMAFPGSMVGLSAYGEPGKQVSAELTYMAWKNETEQETRTESIPLTEGAAGTYKAQWKMEEGVSQLTSLNVKLTDPAKPGTVLEKPAAGFPVQVAGAVELSFTNPSGASLTGSLLTSTSRQYGQQIALLPNSDAYVVNGLYPGKDHSFTLRSPDGRHTWGSLEQVQVEGGKRSKISMNIEQPAQLRFQVVDPTGQPVSGVGLQLFGPGQSYIDASSTYGDGWTSWTDYMKAGDSVTAKVDIGDRMYEQPANQEVILKPGANEQVIKLRAPGEGLVEGFVKGPDGKGVRNAYIASTQTFKGQPVVRRTRTNLEGAYRLSLLEGEAKIEVFETSYMYGTDGPVTVLVTEGGTTTLDLPVKQPSKGIVNTEVRLKYLEDTDFGPPVNMEEMTFLTRIESKRGWMSGYFQNAHQFYGLPGDTVSVCVTGSVPSYMTSCTDVVLDQDGNATAKLFLEEKGARIQGKLAQTHHRWVSGGLYKLKDQGYRSAASYLGDNDFEADGSFNINVPEAGTYVMELNGALPGSPLKYEYATVQFTVSDRQILQVGSVSFSSKSFFSNYYGNYYNALSSRIAPGGTVTMRAGYKNSSGVDASEAKLLIDIPEGTTPVKDAAGRIVVSGAQLAGDPVLDGQTLILPVGTVAQTQSGTLSFQLKVDPAFNKSSAKSSARIRARMGVEQIEESIGSVLLDAPLVTLEAPERVSKPVDSSAPVIKLSGVAPAGSQVNVYDGKLLLGSAAASNTGFWLMAVQELPDLGDPGVHAIRAEVDSNGVKLQSPVSYVHYDNVKPQLLELAMAQAPEGRWMTLNLREGIPNQPYTVVPGNPFQFELKFDKPDEVENVEIYLEGQSGEPVKAVREGGIFRALTPTDKGALGAIYVDYDVKPKPFVLDDKQPTLDELRETLPPTMRDFTAEVTAPFELKDGKYAGTVELTFPQLPGLKITEKLSISPDAKYTASPQEIELAQRSGLPMLNGSVSVTETDDGFKTVSSGYMPMKLLFPSGVPGSLKSALAAKVRALAADEGPDFGTLADVSVETYVQYGEGGEDAGTVYKIKKQYEDSMEFAEKINKIAYKVEVSGMDCIQELPTTVKQAGKALVAVVGGEISKVALGAWTGAMGLTGPGAIAAAGASAVIEDKIDNYVDEQIDAIGTGYNQCRDEDEEKKRKRKKIARLRWIYDPSGYVYEAVPANRLSSVKATVLYQEPASKEWVVWDAGPYEQVNPHDTDDQGKYGWDVPEGKWKVVWEKDGYETQSSAELDVPPPHTEVNAGLVSYEAPKVQSVTGVTAAAGSYVDVELTKYVKVTDAAAAAQAVTVTGPDGSPLEGSAAFVEPADNPADAEGADLSRILRFTSKTSLTPGTGYSVKVNAAFQSYAGVWMAEGHSGTFEVGTRDEEGPTAAGDEVNAEGEGSILRVKFNEKLSSTVDAAKFTLNGSSDSIVSAVRALKPNPEGELTAVDGDYEQTVVLTLSESLAPGTEAQLGILAGAVSDTAGNAAVPKTLKVVSAAGESSNAALASLAVEEGALAPAFDPSVRSYKVEVPSAAETVNLTASLADASAQLVIDGTIAASGVRKTVRIPDTGIIAVRVTAADGTTVREYSVEVVRGTTDPLGTEASLSALTVTPGTLSPVFEPAVETYDVEVAANVTELQIAATAQDSKAKSITIAGEAAVSGTAKTVAIPAGGQIEVVVTAEDGVTKRTYKVAVSRKTDSGSGGDNSGGGSDSSGGGSVPPAKPALTQQEAFTGASGGKGIRVTLRRSDAIASALQTGTDGQKQLLIEVKEQADEFMLQLSADTLAKLTESQAGVLFKTTRLQASIPSALLASVQLPAGAHLSFSMGAASAAEQTAAYEAAALQSDALKPSGQAVSVKLEMIQDQKASLLTFGHPVMVELPVQGSGQEAVYRFDPADAKWAFVWKQRQVSGSRSAIEADASGTYAVMAYADPFDDMKDHWASSDVGWMARRLLVSGAAPGAFHPDHSVSRAEFAALLVRALDLKAVATVGYQGFSDVPEEAWYAADVRRAAEAGLLQGVADNRFAPDALITREQMAVLIWRANVYLREAAGEQAGAGHALKQFKDQGSISSWAEAAAAAALEAGLIQGTAADTFDPQGSATRAQAAVMMKRLLQLGSGQ
>NC_016935.1|WP_014368237.1|405299_405791_-|DUF1992-domain-containing-protein
MLNREREERRRHGHQGEQEAAERPIIPLPKETLEDRDVILHAQLEQHRLANEAYEEFVKNGGLEKLPGFGKPIEVPTGDILASIMKQARVQPPFMMLRTEIRKNMELAMELLKQDPGSPEIDAALDDANKQITELNYQAPSLSLHRRKLTRENLQEQYERWYR
>NC_016935.1|WP_014368238.1|406023_407289_-|erythromycin-esterase-family-protein
MTKSTERIEALRKLAVPLKEKAALDDLVKAASSARCVLLGEASHGTSEFYTLRAELTKRLITEHGCRIIAVEGDWPSCFSVNRYIKGLPGAAGSAAEALAAFDRWPEWMWANHEIGDLVEWLKAHNASLPPERQVGFYGLDVYSLWESMDEILQYLERTGSPNVEEARAAFECFEPFGGEGQSYGISASLFGEGCEDEVVALLAKLRTERTRSEDPQEEALDAEINALVAVDGERYYRAMITHDAESWNIRDRHMTEVLHRILNFHGPDAKAVVWEHNTHIGDARATDMFTDGMVNVGQLAREQMAPGEVYAIGFGTHRGKVMAGTSWGSPAQVMDVPQGISGSWEDLLHHAVGEDCVLLLKDAPAVLRETIGHRAIGVVYRPTHERGNYVPSRLPDRYDAFVHVEVSQAVRPLAGEPVFA
>NC_016935.1|WP_014368239.1|407537_408116_+|hypothetical-protein
MQIEDKEIVEYPSTLKLAGLSIGAAIFVAGGAGLFAWGQEEEDLELVVVGAAGVLFFGGALLYLLYRLLRRRPSLMINAEGIVDHSSYTGGGRIRWEQIKDMTVYELMGQRFIGLELHDPEAFLAKQTPFKRILLRMNRGLVEAAVNIPQTGVQMPLDELHAVMMERWNAASRRKEEAGLETQFGAARRQSD
>NC_016935.1|WP_014368240.1|408368_409118_+|VWA-domain-containing-protein
MSYRIQATEKTPALILYLLDISRSMTLPMGGRRRLDIALDSLTASLKQMVFRSTKGGRLSPRYRVALIAYSDAVYDLLGGIRPIDEVARKGIPDLVPQRLTETAEAFAYAEKLLLAELPGLDGCPAPLVCHITDGTPTGADPEPVVRRIMDMTVPDGAVLVENIFISEHLLAEPVGDVRSWGGIQDDTPFLDETAVRLRRMSSRIPESYLELLHDSGYPLAAGSYMMLPGSSAELVGLGFQMSSATPVR
>NC_016935.1|WP_014368241.1|409117_409960_+|hypothetical-protein
MNTYEYRLDPAEDVPLTTVVVGPALYRFAARRADESRLAGEPSQDDLVLRADETGASFCICDGVSLSFFGGLAARLLGDALLEWCASGIPAKAGEPQVRLSLERLLADLTHTAGEAVRSHPLPNSAAGLLREVLEDKRRLGSEAMFVFGRVDFPCTAYPAGRLVLGRMGDIRIRFAAADGQWESSLTGFTEQRWSTRRGAVGGRPAVLITELPAARSGLTVYTDGWAAFCDGVTTLPPEGPDPWCAARDGEELPADDDQLFFQMQWQMEPPPDHEEEASS
>NC_016935.1|WP_014368242.1|409956_410301_+|EsaB/YukD-family-protein
MNRIMTLSMDRQEVDVEVPDDVPVGRLLPLLAEAAGTAVTGGERLLLEASQPGEAWRILSPGRTLSDEDIRDGAFLRISLTPAAPEDTSGPEKAEAGQEDSSGLPVAGWKPLFS
>NC_016935.1|WP_014368243.1|410366_414437_+|type-VII-secretion-protein-EssC
MQRPQYFQRSPRIKKGIPYGTVEVHRPPAPPAPPKLSLISMLLPAGMTAASVLLLVMLNPNQNSSYLVVQLISMSTMAVSYLVPFLTHLSNKREYKREKAERESKYEAQLESHRKELEKVRELQKSVMLDTDPPPEECVRRIREWSGEVWNRSPQEEDFLHLRLGVGDQPFCIRIKAPEQDGYEKEPLIEASQKLDDDYRTVSHVPVQLPVFESKVIGIVGDRQAAENMVRVLALQLAAHHAPDEVKVGAFFGEEEARRWEWMRWLPHTWDDDRKTRYLAKDMSTTRQALDALYHVLHPRKLASSPGREAEMKLPAWVFFLSDIRPMEDEPLVHLLLREAEALSACTFILSDRRETLPKECGMILEVTLGEGRLLETASGQSGVTGRERYFIPDRITLEQADEAARLLAPYRLRKSAAGELPRVLTLYDMFGVRETGELSAAAHWSKNRYPDTLPVTVGVRAGGKPVQLNIHDKIERRGHGPHGLIAGTTGSGKSEVIQSLIASLALQFHPHELAFMLIDYKGGGMSNTFALLPHLIASITNLEGKGVMDRAQVSLKAELARRQRILNAAGNLQHIDEYYRSPYRDKEPLPHLVIVIDEFAELKKEQPDFMSELISIAAIGRTLGVHLILATQKPAGVVDDKIWSNARFRICLRVQDEADSRDMLRVPDAARISNPGRGYFQVGSNEVFELVQFAWSGAPYRPEAAAAAVEAEAYTVALNGTRHRCAAPAAASRAGDRLDERKQLQVFIDYLAETARAEGIEPLPGPWTPPLPAELFLGDLRDGSSGWNGAGWQPAEGWLQPALGLIDDLANQVQRPLCFPLEEGHLLIYGMPGTGKTTMLQTLLLGLASEHHPEDVQFYVLDFGRMLKDFDPLPHTGAVIQQEEAEKVRRLFRFLAGQLDQRKQLFSEAGVKSLETYRKVTGSAMPALFTVMDGYLSFKDSYPDEHDRWEALLREGASLGLYFVVTANRVSDMFDKIRSNFPLAFSFELADPSDYYFAVGRPVRPLSQAPEGRGLLKGAVPPLEGQIALPAGGADEFERTRAIRETVKRMSEAWNGPRAFRIPVLPEIVSLGALLDGEYGGAADGGAADRPGAKEAVLRVPVGLETEELTLFCPDLRDGPVFVVGSRMEGGKTALLSSWVLALAGANRPEALQLVLADFRRTPSGLYALRQLPHVTGCAVDEDSLLTLLGPLREELERRKFLLQSEGDGAVGASFPAIVLAIDDGEAVARQIGMSYELQGHLEWILKQARGLGVYILFGCIPAEIGNCFDSWTGPVKSAQTGFLLGTTESADLNLFNLKLPYAETGKSLPSGEGFYVRRRHAPFKGALPFTGGAGPEEWVRRITESVGPMTGRMS
>NC_016935.1|WP_013914191.1|414450_415401_+|WXG100-family-type-VII-secretion-target
MRIRVSPEQLGQVALQFQQAQHQSQTSIARMRGAIGRLESQWSGVTREEFYQSFQRASQIMNRYLETLQKIEGDLKQISQRFADTDKKEDSSSELLKKAIISGLSTAGKLGFVASALKVSANAKRADLVDIAVRDWVKNGKVAEVWSKLLPVKSVNTPQKMAAKLGNIDHTLPGSSIKATNMAKHIRGQLKPFGLVGVALTSVGEVKPLVSSIQSDIAKYDGLEAAGHVATDVAYSTTKVAATVGASYAGAVGGAQAGAFLGSFVLPPIGTAVGGIAGAIIGSSLGGAVVSETIENLVPRERFKSGVQKLKGLLGL

Crispr_ID: NC_016935_2

• CRISPR_ID: NC_016935_2
• CRISPR_location: 1008326-1008635
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 5 spacers

Consensus repeat of NC_016935_2

Consensus_repeat	Method
AACACGGAAAANCCGTGT	CRT
TCTTCGGTGGCCCCGGAACACGGAAAATCCGTGTAA	PILER-CR

spacers of NC_016935_2

>2.1|1008344|44|NC_016935|CRT
AAAACCTGTGTGAGCAGCGCTCTACGGTGTTGCAGCGGCGGATT
>2.2|1008406|34|NC_016935|CRT
TAGGTAGTGAGCAGCCGTTCTTCGGTGGCCCCGG
>2.3|1008458|46|NC_016935|CRT
AAAACGAGCGGGAGTGCGCCCCGAGGAGCGCAGCAGCGGCTGGGTT
>2.4|1008522|34|NC_016935|CRT
TAGGTAGTGAGCAGCCGGTCTTCGGTGGCTCCGG
>2.5|1008574|44|NC_016935|CRT
AAGATGAGCGGGAGTGCGCCCCGAGGAGCAGCAGCGGCTGGGTT
>2.6|1008460|44|NC_016935|PILER-CR
AACGAGCGGGAGTGCGCCCCGAGGAGCGCAGCAGCGGCTGGGTT
>2.7|1008540|16|NC_016935|PILER-CR
GGTAGTGAGCAGCCGG

CRISPR arrays and Neighbor proteins around NC_016935_2

CRISPR arrays

The CRISPR arrays of NC_016935_2

>merge|NC_016935|2|1008326-1008635|CRT,PILER-CR
AACACGGAAAAACCGTGTAAAACCTGTGTGAGCAGCGCTCTACGGTGTTGCAGCGGCGGATTAGCACGGAAAATCCGTGTTAGGTAGTGAGCAGCCGTTCTTCGGTGGCCCCGGAACACGGAAAAACCGTGTAAAACGAGCGGGAGTGCGCCCCGAGGAGCGCAGCAGCGGCTGGGTTAACACGGAAAATCCGTGTTAGGTAGTGAGCAGCCGGTCTTCGGTGGCTCCGGAACACGGATAATCCGTGTAAGATGAGCGGGAGTGCGCCCCGAGGAGCAGCAGCGGCTGGGTTAACACGGAAAATGGACCT

>NC_016935|2|2|1008326-1008635|CRT
AACACGGAAAAACCGTGT	AAAACCTGTGTGAGCAGCGCTCTACGGTGTTGCAGCGGCGGATT
AGCACGGAAAATCCGTGT	TAGGTAGTGAGCAGCCGTTCTTCGGTGGCCCCGG
AACACGGAAAAACCGTGT	AAAACGAGCGGGAGTGCGCCCCGAGGAGCGCAGCAGCGGCTGGGTT
AACACGGAAAATCCGTGT	TAGGTAGTGAGCAGCCGGTCTTCGGTGGCTCCGG
AACACGGATAATCCGTGT	AAGATGAGCGGGAGTGCGCCCCGAGGAGCAGCAGCGGCTGGGTT
AACACGGAAAATGGACCT

>NC_016935|2|1|1008424-1008575|PILER-CR
TCTTCGGTGGCCCCGGAACACGGAAAAACCGTGTAA	AACGAGCGGGAGTGCGCCCCGAGGAGCGCAGCAGCGGCTGGGTT
AACACGGAAAATCCGTGTTAGGTAGTGAGCAGCCGG	TCTTCGGTGGCTCCGG
AACACGGATAATCCGTGTAA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016935.1|WP_014368579.1|1017314_1017986_+|NAD(P)H-binding-protein	unknown	unknown	gnl|CDD|187560
NC_016935.1|WP_013914720.1|1010334_1011579_-|glycosyltransferase	unknown	unknown	gnl|CDD|213815
NC_016935.1|WP_013914711.1|1003193_1003703_+|dihydrofolate-reductase	unknown	unknown	gnl|CDD|365932
NC_016935.1|WP_013914731.1|1018496_1019615_-|GerAB/ArcD/ProY-family-transporter	unknown	unknown	gnl|CDD|281794
NC_016935.1|WP_014368577.1|1012312_1014136_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224055
NC_016935.1|WP_013914716.1|1007566_1008067_+|copper-amine-oxidase-N-terminal-domain-containing-protein	unknown	unknown	gnl|CDD|377924
NC_016935.1|WP_014368567.1|1000197_1001520_+|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|223936
NC_016935.1|WP_014368573.1|1005256_1006648_+|glycoside-hydrolase-family-4	unknown	unknown	gnl|CDD|133433
NC_016935.1|WP_014368569.1|1002336_1003131_+|thymidylate-synthase	unknown	unknown	gnl|CDD|234984
NC_016935.1|WP_013914730.1|1018109_1018424_-|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_013914728.1|1016503_1017127_+|DUF3298-and-DUF4163-domain-containing-protein	unknown	unknown	gnl|CDD|378702
NC_016935.1|WP_014368566.1|999689_1000178_+|EpsH-protein	unknown	unknown	gnl|CDD|227350
NC_016935.1|WP_014368578.1|1015972_1016356_+|VOC-family-protein	unknown	unknown	gnl|CDD|319898
NC_016935.1|WP_013914724.1|1014436_1014727_+|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_013914726.1|1014986_1015754_-|TSUP-family-transporter	unknown	unknown	gnl|CDD|182593
NC_016935.1|WP_014368572.1|1004239_1005091_-|AraC-family-transcriptional-regulator	unknown	unknown	gnl|CDD|225117
NC_016935.1|WP_013914715.1|1006803_1007334_+|DUF1572-family-protein	unknown	unknown	gnl|CDD|311521
NC_016935.1|WP_014368568.1|1001541_1002186_+|LPS-biosynthesis-protein	unknown	unknown	gnl|CDD|226453
NC_016935.1|WP_013914721.1|1011755_1012313_+|spore-protease-YyaC	unknown	unknown	gnl|CDD|115518
NC_016935.1|WP_014368570.1|1003797_1004121_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016935.1|WP_014368579.1|1017314_1017986_+|NAD(P)H-binding-protein	gnl|CDD|187560	cd05250, CC3_like_SDR_a, CC3(TIP30)-like, atypical (a) SDRs. Atypical SDRs in this subgroup include CC3 (also known as TIP30) which is implicated in tumor suppression. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine rich NAD(P)-binding motif that resembles the extended SDRs, and have an active site triad of the SDRs (YXXXK and upstream Ser), although the upstream Asn of the usual SDR active site is substituted with Asp. For CC3, the Tyr of the triad is displaced compared to the usual SDRs and the protein is monomeric, both these observations suggest that the usual SDR catalytic activity is not present. NADP appears to serve an important role as a ligand, and may be important in the interaction with other macromolecules. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	9.47557e-67
NC_016935.1|WP_013914720.1|1010334_1011579_-|glycosyltransferase	gnl|CDD|213815	TIGR03469, HpnB, hopene-associated glycosyltransferase HpnB. This family of genes include a glycosyl transferase, group 2 domain (pfam00535) which are responsible, generally for the transfer of nucleotide-diphosphate sugars to substrates such as polysaccharides and lipids. The genes of this family are often found in the same genetic locus with squalene-hopene cyclase genes, and are never associated with genes for the metabolism of phytoene. Indeed, the members of this family appear to never be found in a genome lacking squalene-hopene cyclase (SHC), although not all genomes encoding SHC have this glycosyl transferase. In the organism Zymomonas mobilis the linkage of this gene to hopanoid biosynthesis has been noted and the gene named HpnB. Hopanoids are known to feature polar glycosyl head groups in many organisms.	1.51989e-30
NC_016935.1|WP_013914711.1|1003193_1003703_+|dihydrofolate-reductase	gnl|CDD|365932	pfam00186, DHFR_1, Dihydrofolate reductase.	2.26785e-83
NC_016935.1|WP_013914731.1|1018496_1019615_-|GerAB/ArcD/ProY-family-transporter	gnl|CDD|281794	pfam03845, Spore_permease, Spore germination protein.	3.09674e-48
NC_016935.1|WP_014368577.1|1012312_1014136_+|ABC-transporter-ATP-binding-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	3.24096e-179
NC_016935.1|WP_014368572.1|1004239_1005091_-|AraC-family-transcriptional-regulator	gnl|CDD|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	7.51122e-26
NC_016935.1|WP_014368567.1|1000197_1001520_+|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	gnl|CDD|223936	COG1004, Ugd, Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane].	0
NC_016935.1|WP_014368573.1|1005256_1006648_+|glycoside-hydrolase-family-4	gnl|CDD|133433	cd05297, GH4_alpha_glucosidase_galactosidase, Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases. Glucosidases cleave glycosidic bonds to release glucose from oligosaccharides. Alpha-glucosidases and alpha-galactosidases release alpha-D-glucose and alpha-D-galactose, respectively, via the hydrolysis of alpha-glycopyranoside bonds. Some bacteria simultaneously translocate and phosphorylate disaccharides via the phosphoenolpyruvate-dependent phosphotransferase system (PEP-PTS). After translocation, these phospho-disaccharides may be hydrolyzed by the GH4 glycoside hydrolases such as the alpha-glucosidases. Other organsisms (such as archaea and Thermotoga maritima) lack the PEP-PTS system, but have several enzymes normally associated with the PEP-PTS operon. Alpha-glucosidases and alpha-galactosidases are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.	7.78705e-98
NC_016935.1|WP_014368569.1|1002336_1003131_+|thymidylate-synthase	gnl|CDD|234984	PRK01827, thyA, thymidylate synthase; Reviewed.	0
NC_016935.1|WP_013914728.1|1016503_1017127_+|DUF3298-and-DUF4163-domain-containing-protein	gnl|CDD|378702	pfam11738, DUF3298, Protein of unknown function (DUF3298). This family of bacterial protein C-terminal regions is highly conserved but the function is not known. Several members are annotated as being endo-1,4-beta-xylanase-like, but this could not be confirmed, and the structure can be defined as a heat-shock cognate 70kd protein 44kd ATPase.	1.23315e-15
NC_016935.1|WP_014368566.1|999689_1000178_+|EpsH-protein	gnl|CDD|227350	COG5017, COG5017, Uncharacterized conserved protein [Function unknown].	3.67852e-28
NC_016935.1|WP_014368578.1|1015972_1016356_+|VOC-family-protein	gnl|CDD|319898	cd06587, VOC, vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). Type I extradiol dioxygenases catalyze the incorporation of both atoms of molecular oxygen into aromatic substrates, which results in the cleavage of aromatic rings. They are key enzymes in the degradation of aromatic compounds. Type I extradiol dioxygenases include class I and class II enzymes. Class I and II enzymes show sequence similarity; the two-domain class II enzymes evolved from a class I enzyme through gene duplication. Glyoxylase I catalyzes the glutathione-dependent inactivation of toxic methylglyoxal, requiring zinc or nickel ions for activity. The antibiotic resistance proteins in this family use a variety of mechanisms to block the function of antibiotics. Bleomycin resistance protein (BLMA) sequesters bleomycin's activity by directly binding to it. Whereas, three types of fosfomycin resistance proteins employ different mechanisms to render fosfomycin inactive by modifying the fosfomycin molecule. Although the proteins in this superfamily are functionally distinct, their structures are similar. The difference among the three dimensional structures of the three types of proteins in this superfamily is interesting from an evolutionary perspective. Both glyoxalase I and BLMA show domain swapping between subunits. However, there is no domain swapping for type 1 extradiol dioxygenases.	2.18584e-19
NC_016935.1|WP_013914726.1|1014986_1015754_-|TSUP-family-transporter	gnl|CDD|182593	PRK10621, PRK10621, hypothetical protein; Provisional.	1.79122e-40
NC_016935.1|WP_013914721.1|1011755_1012313_+|spore-protease-YyaC	gnl|CDD|115518	pfam06866, DUF1256, Protein of unknown function (DUF1256). This family consists of several uncharacterized bacterial proteins which seem to be specific to the orders Clostridia and Bacillales. Family members are typically around 180 residues in length. The function of this family is unknown. These proteins are related to peptidase family M63 and so may be peptidases.	5.47611e-51
NC_016935.1|WP_013914715.1|1006803_1007334_+|DUF1572-family-protein	gnl|CDD|311521	pfam07609, DUF1572, Protein of unknown function (DUF1572). These proteins, from several diverse bacteria, share a short conserved sequence towards their N termini.	1.20524e-85
NC_016935.1|WP_013914716.1|1007566_1008067_+|copper-amine-oxidase-N-terminal-domain-containing-protein	gnl|CDD|377924	pfam07833, Cu_amine_oxidN1, Copper amine oxidase N-terminal domain. Copper amine oxidases catalyze the oxidative deamination of primary amines to the corresponding aldehydes, while reducing molecular oxygen to hydrogen peroxide. These enzymes are dimers of identical subunits, each comprising four domains. The N-terminal domain, which is absent in some amine oxidases, consists of a five-stranded antiparallel beta sheet twisted around an alpha helix. The D1 domains from the two subunits comprise the 'stalk' of the mushroom-shaped dimer, and interact with each other but do not pack tightly against each other.	1.04985e-23
NC_016935.1|WP_014368568.1|1001541_1002186_+|LPS-biosynthesis-protein	gnl|CDD|226453	COG3944, COG3944, Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane].	1.48956e-36

Protein sequences

>NC_016935.1|WP_013914716.1|1007566_1008067_+|copper-amine-oxidase-N-terminal-domain-containing-protein
MKRKMLGIWAGLLLFAAPVHAREEAPVVRVFVDGEQVIFEHPPILEQGTTLVPFRAISEKLGFEVAYRVENGEQSVTAVKGGETVTMYIGNRIANSAEGRVLLEQAPRIEHDLAYVPLRFLAEAMHVEVEWDGEQTAVRLHTQAPADGGAPPEEKAADPEPEAAGA
>NC_016935.1|WP_013914715.1|1006803_1007334_+|DUF1572-family-protein
MGEAQELGKVMLEESIQAFRSMKALGDRTLAQLEDVQFGEALDPESNSMEVLIRHMHGNMVSRWTDFLTTDGEKPDRDRDGEFEGAGAGREELLALWEAGWAVVFGTLESLQPADLLRTVTIRGEAHTVVKAIQRQVSHYGYHVGQMVFLGKHLRSESWQTLSIARGQSRAFRPGT
>NC_016935.1|WP_014368573.1|1005256_1006648_+|glycoside-hydrolase-family-4
MEETRISKPKVVVIGAGSLFFGRQSIWQMVQSPYLNNGTLALVDSDEERLSKMVTLAKMVAKENGVPLQVEGSTNRREVLQGADFVVLSFAKDSVKYRGIDCEVSLQYGIRMCSGDTIGPGGIFRAMRELPVIMECAKDIEEICPDAWVINYINPSTVHGIALSRYAPKLKSFALCDSHHMPHKKAHYAIRAGIIQHPSEFTEEIDRRFDCRIAGVNHFTWLLKAEYDGKDVMSLIAEALRRSAGTENDGGDKGAKALHNDAITYELYDIFGSIPTCTAHTKEYVRYWQGLGKTEDAIPPLSIWETEDRYKRHEEMWRQVDDFISGRIPIADYMKIMGPDHATDIIESMVGNLGKRFFINTLNNGAVTNMNDDAFLELLSEVSLSDGIKPLPVGDMPRGIRGMQELVLDTHELTAEAVVERSFTKLRRAFMTDPLVNSIHDADLIIKELLEREKDIIPSYWYE
>NC_016935.1|WP_014368572.1|1004239_1005091_-|AraC-family-transcriptional-regulator
MNSTMPVMDIFNELSEFITLRMKSCKELTHDRDWHEHKAHSDYDLWFIQSGTVQIHIGETEHTANPGDVVFFYPGVPYRAASTDKGCRFIYAHFDFGMGTQQRILNDFRLSGIITRELIQDEAILFDNSFRQVERFGGTSGNRLHLKACMTALIAKIIELYGKGHYHGTFPKERMPGHSQGKLDLLQPVFQYIHNHLHQSIRMSELASLVGISEKYFISYFKKALGLTPGQYIYQIKMNRARDYLYEKKYTVHQIAGFLGYPDPFTFSKAFKKYYDVPPSKFV
>NC_016935.1|WP_014368570.1|1003797_1004121_+|hypothetical-protein
MTEVNQHQMPNRHVIDNVEKAIQVAKDAEMAVRHAQLESNPQKLRTALAQLETAQHALGNAQAQLKLNSRDREHHGQEFVQVQNELTQSEQSLDITSQNTELPKQVR
>NC_016935.1|WP_013914711.1|1003193_1003703_+|dihydrofolate-reductase
MTVSYMFAMDEARGLGYQNRMPWYLPADFAYFKQTTLEHTVLMGRKTFDSLGGKSLPRRRNVILTRDKSFEAPGCETVTSPEDAVKPYRPGGEQADEELFVIGGAEIFSLLMPYADRMYITEIHHTFEVDTYFPELDRTEWKEVSRTKGPKDERNPYDYEFVIYERAAN
>NC_016935.1|WP_014368569.1|1002336_1003131_+|thymidylate-synthase
MKAYLELLEDILEHGVSKEDRTGTGTLSVFGRQLRFNLAEGFPLLTTKKMHIKSILHELLWFLSGDTNINYLKENGVTIWDEWADENGDLGPVYGSQWRSWPAPDGRSIDQISAVVEALKKNPDSRRHLVSAWNPAEVDQMALPPCHYAFQFYVAGGKLSCMFQMRSVDTFLGLPFNIASYAFLTHMVAQQCDLEVGELIWTGGDVHIYSNHLEQVKLQLTREPYPQPQLVIKRKPDSILGYRYEDFEITGYQSHPAIKAPIAV
>NC_016935.1|WP_014368568.1|1001541_1002186_+|LPS-biosynthesis-protein
MELSELISIILRRIWILLIAVLVCVGAAAYVSYFHMEKEYEASASMYVLKSNKTPSNNLYQELLAGSSLVKDYKELIKSKTVLKQVKDQLERSHTWAAQMTVEELSQKLEISNKNDTHILVAAAKDASPERAAVIANQVAVVFIEYSRQITVDESVQLIDAAEAADAPSQPKPLINMAVAAVVGVLVGLLAIFLQVQSQRSTTARRGKKPLEFS
>NC_016935.1|WP_014368567.1|1000197_1001520_+|UDP-glucose/GDP-mannose-dehydrogenase-family-protein
MQKIAVVGTGYVGLVTGTCLSDFGLETICVDIDETKIKRLKEGHIPIYEPGLEEMVTRNIQYRRLEFTTDIQSAVEQAEVIFIAVGTPAREDGSADLKYVLTVAEQIARSMNGYKVIVNKSTVPVGTGQKVKEVVQQVLDETGKSFEFDVVSNPEFLREGNALHDFTHPDKVVVGTESQRAKDIMKQVYRVLYLNETPFIFTNIETAEMIKYANNAFLAVKISFINEIANLCEKVGANVQQLAQAIGKDGRIGSKFLHAGPGYGGSCFPKDTLALAHIGQAYDSPMRLVETTIEVNERQKLNMVEKIETAYEGGLAGRKLAILGLTFKPKTDDMRDAPSLTIIRELEKRGVSFRVYDPAGMEEGRWRLEGVRGIEFCTDEYSAMEGCDGVVIVTEWHQFRNLDLKRVQELLVSPNFFDLRNIYDKAEMANQGFAYYGVGV
>NC_016935.1|WP_014368566.1|999689_1000178_+|EpsH-protein
MILVSLGTQDFPFNRLLEKIDELIEKKVIQEEVIAQTGYSSYVPRHFKYTKFTTFDEFEDLLDQCRILITHGGTGTIVGGLRKKKRIIAVPRLKKYAEHVDDHQTEIINLFSDKNFIIGLEDVSGLEQALRAIETFEPIDYVSGNQKIVSLIDNFLGRTVRN
>NC_016935.1|WP_013914720.1|1010334_1011579_-|glycosyltransferase
MRFLLLWALAALGYWLVLLWDTLRAKKWMFTLPPSAGNTRINHQSNIQGSPDSSTRRASLTDAPLVSVIIAAKEEESSITETVRHLLSQNYPRLEIIAVNDRSRDATGRKLDELRRWSESKADITVPLRVIHITTLPQGWLGKNHALYQGYLQARGKLLLFTDADVRFHPDTVADAVRYLQEEQADHLTLSPDMMVKGLWLKAFVDYFFFTLCLYLRPWRANDDFQFKAGMGIGAFNLMTRYGYEKIGTHRAIAMRPDDDLQLGRHVKQARLRQRLASGHHHIGVEWYKSLGGAVEGLEKNIFSGFGYRTGLAILAVLGQLALFLYPVLGMLLIPGGTAWICALAVVTMAAVYLLLIRSLTGKAGWTVLLLPLTTGLLCYVVVRSVWLTLKQGGIYWRGTFYSLKELRRMQEEN
>NC_016935.1|WP_013914721.1|1011755_1012313_+|spore-protease-YyaC
MTGEQAKPLFRKKIRAAELPEFLRMIRSEGVSAENLQFLCIGTDRSTGDALGPLVGTMLEEAGFRGVIGTLARPFDASNMRERLAEIPPGRKVIAIDACLGQPASLGWYQVSNRPIEPGKSVGKQLPHVGDYSIAAIVNVDAGQKYAILQSTSLHRVMNMAREITAGILGTFLPGPLPAGPQEEE
>NC_016935.1|WP_014368577.1|1012312_1014136_+|ABC-transporter-ATP-binding-protein
MRQGGGFGEGGPMHRVQNRGRAKLEDVSTARIYRLFRGYRWQLAAILVMALGGAVLGLIPPLVMKEIIDHALPDGDRRQLVLLTVLMVLLPLLSGLLGVWQNHENTKVGQGVMRDLRQSLFGNLQRQAMSFFTDAKSGEIIQRLTGDVQAVQNVVTTLVVSAVTQSVIVLTTVVILFALDWQLAILSVAVLPLFLLPVRRVSAVRKKLRGEAQRVRGDMSARLGELFGVSGAMLTRIFQGERRQQEQFAVLNEKVMDLELRLNLVGRWYGMVIGVLGPLGTALIYLYGGWKVIDGSMTIGSIVAFAAYLGRLYGPVGTLLNLRVEVGTALGVFQRLFEYQDLVPEVREAENAKVLPPVRGHIAYRSVSYAYQPGQYALRGVSFEAAPGEVVAIVGPSGAGKSTLIGMLARLYDPTEGEVTVDGQDIRSVTLESLRSQVAFVTQESFLFHASVRDNLLFARADASPEELEEACRQAYIHEVIASLPAGYDTEVGERGHRLSGGERQRLAIARAILKNPRILILDEATSHLDSASEAYVQAALDELMRGRTTLVIAHRLSTILSADRIVVLEGGRVAESGRHEELLEKRGLYAKLFHTQFAAGGTPLSS
>NC_016935.1|WP_013914724.1|1014436_1014727_+|hypothetical-protein
MRQINHINITDTNGKIYCCLRNKIVTLDDHQKQKFCGGCKMFAGDAGGRGVECVWDDIRPVANPHIVNNPFTEMLSNQARRVNLTDHLSTVAVFGV
>NC_016935.1|WP_013914726.1|1014986_1015754_-|TSUP-family-transporter
MEWPSTDMLLFLIAAGFVASFIDSVVGGGGLVSVPALMLTGLPPSMVLGTNKLGGTLSSLTSTASFLASGKVSGRLVLLLFPLAFIGSAFGTYTVHLVPSSFMRPLVVVMLIAVLVYTLFKKNWDGTGVQLKWTGPRRLVIGLAALVIGFYDGFFGPGTGSFLLFVFLLFGFDFVGASANAKVLNFASNIASLAAFFLLDSVHLGYGIPMGLSMIAGALVGSQLAIRKGSTYVKPLFIIVTGILIGKQLWDLAAG
>NC_016935.1|WP_014368578.1|1015972_1016356_+|VOC-family-protein
MIHKLEHIGIMVSNMDASIRFYTEVLGLQLARREQIDNGPELGFLSFPGSEHIEIELIGRGTEGLSGSGIVNHVAFTVSDIEGEMARLQDLGVRFEEGSSKVILNGVRIAFFQGPDGERLELFQPAP
>NC_016935.1|WP_013914728.1|1016503_1017127_+|DUF3298-and-DUF4163-domain-containing-protein
MEWISGEDRAPRERIMTRRLVKPRLDVKYPQVAGLRNGFVQRMVNHAILDAVYDLIRIQGYVQDKTKTITGTYHVKLHQKELLSLLYENYGYAEKAAHGITYQSSQTFDLEDGRLYALADLFKPGSDYIGRLSKIIAREFKERDIPMIAEFKTITPEQPYYLTDKAIGIYFQLYEYTPYVYGFPTFEIPFAEVKDIIDPQGPIGRLM
>NC_016935.1|WP_014368579.1|1017314_1017986_+|NAD(P)H-binding-protein
MNKTAIVAGATGLIGRELVRQLKQDAACGRVIALVRSRTDWEGGQPEELVTDWSEAQLEPLLRDKLPGADVYCALGTTIRKAGSKEQFRRVDLEYPLTLGRLACAHGASRLLVVSSTGADSSSRFFYSRVKGEMEEALRALGLPELHFFRPSLLLGQRKNDHRPGEKFAEAVSGAMPFLFRGPLQRYKPIQAAAVARGMIRAALREHGGEQVWESERIAELSR
>NC_016935.1|WP_013914730.1|1018109_1018424_-|hypothetical-protein
MNPGNKMKHSQPLPSARQIRRTCSRELYRARKKLGGWIPPEKVSQAEELYYKKVLLNLPYIAENGSNRKLLADWFDENVCGEIAELWSVEPEALGRAFRESFGG
>NC_016935.1|WP_013914731.1|1018496_1019615_-|GerAB/ArcD/ProY-family-transporter
MKAPILNARQLYCLVFLFELGSAVIVGLGMQAERDAWLAILIGMSAGLLLAVVFLYVYRRHEGHSLIGILQLRLGPAAGRLVGGIYVAYFLYIAARVLRDFGEVLVTTILNQTPLLSVNALMVVIICWSLSLGMEVIGRSAEIIIRLVSFMAIVTVPAILASDILEPRRFLPVLEKGLMPVLQTAFPLTLTFPFGETIVFLMVLPHLCSSRKAARPFLLAMLTAGLTLTAVVSLDIAVLGPGRAAAEQFPLLAALGKIQVGEVIQRLDAVALSTLILGGYFKITIFTYAGVRGLSELTRTSGRKAELAQLAAIGLLILAASVGMSASFPEHIDVGLKKVPYQMHLPLQVGVPVLLALLALVFSRRKRPYPSA

Crispr_ID: NC_016935_3

• CRISPR_ID: NC_016935_3
• CRISPR_location: 1776174-1776361
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 3 spacers

Consensus repeat of NC_016935_3

Consensus_repeat	Method
AATAGCGGAACTCAGATGCGCTAT	CRISPRCasFinder

spacers of NC_016935_3

>3.1|1776198|27|NC_016935|CRISPRCasFinder
CGCGGTATTTCCCGTCATTTCCCGGAG
>3.2|1776249|38|NC_016935|CRISPRCasFinder
TGGCCGGAAAGGCCTCGATAAGGAGCCCGGAGTGATGG
>3.3|1776311|27|NC_016935|CRISPRCasFinder
TTCGCTGGACGGTTCGTTTAGGCTGAG

CRISPR arrays and Neighbor proteins around NC_016935_3

CRISPR arrays

The CRISPR arrays of NC_016935_3

>merge|NC_016935|3|1776174-1776361|CRISPRCasFinder
AATAGCGGAACTCAGATGCGCTATCGCGGTATTTCCCGTCATTTCCCGGAGAATAGCGGAACTCAGATGCGTTATTGGCCGGAAAGGCCTCGATAAGGAGCCCGGAGTGATGGAATAAGGCATCACAGTTCCGCTATTTCGCTGGACGGTTCGTTTAGGCTGAGAATAGCGAATCAGAGTTCCGCTAT

>NC_016935|3|1|1776174-1776361|CRISPRCasFinder
AATAGCGGAACTCAGATGCGCTAT	CGCGGTATTTCCCGTCATTTCCCGGAG
AATAGCGGAACTCAGATGCGTTAT	TGGCCGGAAAGGCCTCGATAAGGAGCCCGGAGTGATGG
AATAAGGCATCACAGTTCCGCTAT	TTCGCTGGACGGTTCGTTTAGGCTGAG
AATAGCGAATCAGAGTTCCGCTAT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016935.1|WP_014369075.1|1772718_1773924_-|YheC/YheD-family-protein	unknown	unknown	gnl|CDD|373047
NC_016935.1|WP_014369068.1|1764378_1764978_-|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_013914974.1|1767234_1767831_+|DUF975-family-protein	unknown	unknown	gnl|CDD|283754
NC_016935.1|WP_014369072.1|1770213_1770780_+|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_014369074.1|1771605_1772712_-|YheC/YheD-family-protein	unknown	unknown	gnl|CDD|373047
NC_016935.1|WP_013914993.1|1787588_1787870_+|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_014369073.1|1770833_1771514_+|HAD-hydrolase-like-protein	unknown	unknown	gnl|CDD|136007
NC_016935.1|WP_013914991.1|1786172_1786949_-|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl|CDD|224268
NC_016935.1|WP_013914990.1|1785348_1786176_-|HAD-family-phosphatase	unknown	unknown	gnl|CDD|223635
NC_016935.1|WP_014369076.1|1773924_1775292_-|YheC/YheD-family-protein	unknown	unknown	gnl|CDD|373047
NC_016935.1|WP_187297999.1|1779884_1780091_+|hypothetical-protein	unknown	unknown	gnl|CDD|199890
NC_016935.1|WP_014369080.1|1780589_1781198_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|379534
NC_016935.1|WP_164923372.1|1779680_1779857_+|hypothetical-protein	unknown	unknown	gnl|CDD|273975
NC_016935.1|WP_013914989.1|1784188_1784647_-|MarR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|197670
NC_016935.1|WP_014369081.1|1781453_1782665_+|FAD-dependent-monooxygenase	unknown	unknown	gnl|CDD|223727
NC_016935.1|WP_014369079.1|1777934_1779302_-|YheC/YheD-family-protein	unknown	unknown	gnl|CDD|373047
NC_016935.1|WP_187297998.1|1766178_1766787_-|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_014369069.1|1765398_1766055_-|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_014369078.1|1776449_1777904_-|YheC/YheD-family-protein	unknown	unknown	gnl|CDD|373047
NC_016935.1|WP_014369071.1|1768010_1769885_-|collagen-like-protein	unknown	unknown	gnl|CDD|236090

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016935.1|WP_014369075.1|1772718_1773924_-|YheC/YheD-family-protein	gnl|CDD|373047	pfam14398, ATPgrasp_YheCD, YheC/D like ATP-grasp. A member of the ATP-grasp fold predicted to be involved in the modification/biosynthesis of spore-wall and capsular proteins.	4.17152e-102
NC_016935.1|WP_164923372.1|1779680_1779857_+|hypothetical-protein	gnl|CDD|273975	TIGR02104, pulA_typeI, pullulanase, type I. Pullulan is an unusual, industrially important polysaccharide in which short alpha-1,4 chains (maltotriose) are connected in alpha-1,6 linkages. Enzymes that cleave alpha-1,6 linkages in pullulan and release maltotriose are called pullulanases although pullulan itself may not be the natural substrate. This family consists of pullulanases related to the subfamilies described in TIGR02102 and TIGR02103 but having a different domain architecture with shorter sequences. Members are called type I pullulanases.	0.000772749
NC_016935.1|WP_014369079.1|1777934_1779302_-|YheC/YheD-family-protein	gnl|CDD|373047	pfam14398, ATPgrasp_YheCD, YheC/D like ATP-grasp. A member of the ATP-grasp fold predicted to be involved in the modification/biosynthesis of spore-wall and capsular proteins.	4.87332e-103
NC_016935.1|WP_014369071.1|1768010_1769885_-|collagen-like-protein	gnl|CDD|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	3.04692e-10
NC_016935.1|WP_013914974.1|1767234_1767831_+|DUF975-family-protein	gnl|CDD|283754	pfam06161, DUF975, Protein of unknown function (DUF975). Family of uncharacterized bacterial proteins.	8.72575e-34
NC_016935.1|WP_014369073.1|1770833_1771514_+|HAD-hydrolase-like-protein	gnl|CDD|136007	PRK06698, PRK06698, bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Validated.	1.25592e-41
NC_016935.1|WP_013914991.1|1786172_1786949_-|DeoR/GlpR-transcriptional-regulator	gnl|CDD|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	1.05818e-81
NC_016935.1|WP_014369076.1|1773924_1775292_-|YheC/YheD-family-protein	gnl|CDD|373047	pfam14398, ATPgrasp_YheCD, YheC/D like ATP-grasp. A member of the ATP-grasp fold predicted to be involved in the modification/biosynthesis of spore-wall and capsular proteins.	5.6752e-107
NC_016935.1|WP_187297999.1|1779884_1780091_+|hypothetical-protein	gnl|CDD|199890	cd02860, E_set_Pullulanase, Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase). E or "early" set domains are associated with the catalytic domain of pullulanase at either the N-terminal or C-terminal end, and in a few instances at both ends. Pullulanase is an enzyme with activity similar to that of isoamylase; it cleaves 1,6-alpha-glucosidic linkages in pullulan, amylopectin, and glycogen, and in alpha-and beta-amylase limit-dextrins of amylopectin and glycogen. The E set domain of pullulanase may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end and may be involved in homodimeric/tetrameric/dodecameric interactions. Members of this family include members of the alpha amylase family, sialidase, galactose oxidase, cellulase, cellulose, hyaluronate lyase, chitobiase, and chitinase. This domain is also a member of the CBM48 (Carbohydrate Binding Module 48) family whose members include maltooligosyl trehalose synthase, starch branching enzyme, glycogen branching enzyme, glycogen debranching enzyme, isoamylase, and the beta subunit of AMP-activated protein kinase.	1.53619e-17
NC_016935.1|WP_014369080.1|1780589_1781198_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|379534	pfam14278, TetR_C_8, Transcriptional regulator C-terminal region. This domain is a tetracycline repressor, domain 2, or C-terminus.	6.49493e-18
NC_016935.1|WP_013914989.1|1784188_1784647_-|MarR-family-transcriptional-regulator	gnl|CDD|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	3.71064e-20
NC_016935.1|WP_014369081.1|1781453_1782665_+|FAD-dependent-monooxygenase	gnl|CDD|223727	COG0654, UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion].	1.69301e-28
NC_016935.1|WP_013914990.1|1785348_1786176_-|HAD-family-phosphatase	gnl|CDD|223635	COG0561, Cof, Predicted hydrolases of the HAD superfamily [General function prediction only].	5.00082e-45
NC_016935.1|WP_014369078.1|1776449_1777904_-|YheC/YheD-family-protein	gnl|CDD|373047	pfam14398, ATPgrasp_YheCD, YheC/D like ATP-grasp. A member of the ATP-grasp fold predicted to be involved in the modification/biosynthesis of spore-wall and capsular proteins.	1.73635e-102
NC_016935.1|WP_014369074.1|1771605_1772712_-|YheC/YheD-family-protein	gnl|CDD|373047	pfam14398, ATPgrasp_YheCD, YheC/D like ATP-grasp. A member of the ATP-grasp fold predicted to be involved in the modification/biosynthesis of spore-wall and capsular proteins.	1.5888e-104

Protein sequences

>NC_016935.1|WP_014369076.1|1773924_1775292_-|YheC/YheD-family-protein
MSLTTCTIHVTQRQERAVYLSGDLAKALKLSKTRTVTLKLGSKSVSLSLKLLKKSGNHLYLTPTVYTQLKLPRNGTTMVTTSSGRDIRLGPLIGILTNVVKSTTSPFGSRTEFIREFMRAGSDKAFYFGFSPSDVNWTQETVSAIVPRSEGGWVRKVLPLPDVVYNRLPSRRAEKLASMNAFKQRFIRRGIPLFNWSFFDKWDVYHLLEGTDAFRYVPESKINPNSTQVKEMLEKHKFIYLKPTAGSLGIGIYRLTYNPKRGYYARFRKGSRNVLLRFSRFESLIAHVNRHSNNMQGYVIQQGIRLIEIDSCPIDFRFHMTKNSSNQWVVAAIGAKKAGKGSVTTHVRTGGMLMTPEQVLRQIFGSRADTVLTNAKESAIKLAEDIETKHRHTLGELGFDIGIDQNERIWMFEANSKPGRSIFKHPALKEQGKASLQYIYDYCLYLSRFRSRRES
>NC_016935.1|WP_014369075.1|1772718_1773924_-|YheC/YheD-family-protein
MDLHAQQKKTGRPTMAILTYVDEKRIFRGNQDNFIDLIRKGEEHGVLVYVMTTADFKLSGDTAVGYTYAASSKKWKRQVFPLPHVIYNRIPYRKFELLPEVQQILQTCLRHRQIHFFNPSFFNKWTLFEWLSKSKETRSVIPATQRLSPGGEEIETLLGSYPFLYLKPIRGKAGKGIMKVSRVENSSKSRMFELSIQDKTKSHISRYPSTRQLWTELGPLVGSQDYIVQQGITLSLYKQRPFDLRVLVQKNGKGAWSVAGIGARLAGKMSITTHVPRGGSIDDPAKLLAYSFGTTTAKKILIRAKKTALTVARRIESASGHILGEMSMDLGVDSDGRIWFFEANSKPMKFDEPPIRQKSLENLIQYCIHLSKLKRSAAAGDSAVSLQQLTGVRRPTPRRRR
>NC_016935.1|WP_014369074.1|1771605_1772712_-|YheC/YheD-family-protein
MSRQLGVLAMYLPGRKLEELSFFRKLCVSGRKLGLEVLVFTPDDVNEDGTRIQAMTYDPEKGSWVRRSCGFPPLIYDRCRYHGVENYRKLTRFRSRYAKLRYLSRKLANKWTVHQALAEHDEILPHLPATVRYHSVKDVEDLLKSHGVIYMKPKSGTGGRGIVRLQRLQGGDAVLLQGRDPGRRIIPVQKLAVRHLPSKLAGWKLEEKYIIQQGIPLTLKDGRVHDFRMLVQKDGEGQWQVTGCAGRIGPRRSVTSNLHGGGTAIPMETLLKNRFGSEEKVASIKKKAYSLGLLVVEHLEKRFGMQCEVGIDLAVDPKGGVWLLEVNPKPSREVFSRIGQRETYRQAVARPMEFAAWLYKQKISGVTR
>NC_016935.1|WP_014369073.1|1770833_1771514_+|HAD-hydrolase-like-protein
MTARTMPEAMIFDVDGTLFQTETLLLPAYHATFDRLRSEGLYVGETPPEQYILGSLGMLLEHIWQQVIPESDVAVHRRADELLLQYQVEGMARGEGLLYEGVAETLKELRARGIRLFTASNGLEGYVKGVIRAQGLEPLFESGGLFSAGEHSTRSKVDLVRKLLDQYGIRSAWMVGDRSSDVEAGHANGLFVVGCDYAGFRKEGELDEADVRIRDFREIVGLLPER
>NC_016935.1|WP_014369072.1|1770213_1770780_+|hypothetical-protein
MVTLACFLRVKGWKDLDRFHSTVLYMISANVLYFVFTTNYLLWAFVPDVPLYPILNELLYTLIVFPCSVVLFLKGCPEEKGLPVWHYLKWVAFFAVPEALYAYTGHIAYGHGWSWGWSAAFDLMMFPMLWLHSRRPVLAYVLSVGITTLLLLLFRVPLAGLMEFDGATSGGPDWFTLTSPLSAWFYEG
>NC_016935.1|WP_014369071.1|1768010_1769885_-|collagen-like-protein
MSVNFTNLITNPSFEKGLSPWAAINGTVGSSPAAARAVVVVSKIARAGSLGAAVDDVFIIRGIASGLAGPTGAAGPTGAAGATGPTGPAGPAGTTGAAGASGPTGATGATGPTGHIGPTGPVGPTGATGAVGATGATGATGTTGDTGPTGSTGSTGATGAPGATGATGPAGATGDTGPTGPAGDIGPAGPTGATGATGPVGDTGATGPVGPTGATGAVGATGATGATGATGDTGPTGPVGLTGDTGATGATGATGPMGPAGDTGPTGPVGLTGATGATGATGATGSTGPTGDTGAVGPIGPAGATGATGPTGATGATGPAGDTGAVGPIGPTGATGATGPTGATGATGPAGDTGAVGPIGATGATGAAGATGATGTTGPTGDTGAVGPIGPAGATGPAGPTGATGATGPTGDTGPVGPIGPTGATGAVGPTGATGSTGPTGGTGAVGPIGPAGATGPTGPTGATGTTGPTGATGPIGPTGVTGATGPGTSFSFNQLTTTLPVTPGTETIVNTLTVTTLPGQLVQINAHTEVDQVSSTSGTTFSYELIQRLRRNGDLITDVHVAGGGSKQVGVAFPQDEEPVIIWADVPPPGTHVYTITIQIINAVNVGSVTAESRSLHAIVIQT
>NC_016935.1|WP_013914974.1|1767234_1767831_+|DUF975-family-protein
MEGIASITELKTRALEQLRGNWFKAAVVTLIVVGLSLLVSEIPKVGSLISLLISGPISWGSAYFFLRLRRGEGASIEDILQGFVRFVPALVLYLLTTLFVLLWMLLLIVPGIVAALSYSMAYYIRIDEPELSAMEALRRSKEMMKGHRWRFFVLGLSFIGWILLAVVTAGIGFLWVGPYMSVTSANFYTNLKASQIHG
>NC_016935.1|WP_187297998.1|1766178_1766787_-|hypothetical-protein
MMILRFESLIERRKTNFFEFGYYIVITVFLGAEQFLMMALGITVIILIAIIVAMPKKLSLIEYYCTSLFAFLLNATSDFSLNLQFKLYGYFQPGVDIGGYVIVYIIGPCISTLFLNYFPVNRSVLIKLFYIIAWSLFSILYEIFIALPSGMIYYNGWKWWYSGLLYPVLFLILVADWKLVRNMLKHHLRSKKGLLSDSSSGE
>NC_016935.1|WP_014369069.1|1765398_1766055_-|hypothetical-protein
MTQTQADYFRKLVAGQEVITRQGVDYWLIYSNINTWQFWTILAMLIVPLALLYKFIDRTMIYKIAFFGFATHVLFAYTDAFGIRYGLWGYPYQVLPFLPSVSLDASLIPIAIMFVFQWTLKRRKNFHLYAFLTALAFGFGFKPLLVLSGLFEKYKWVNYIIIFLIYLVLFEGAYLLTSLFEKMKTASNSKERDKKTPSWINLIYLNRRILGRKKSRIT
>NC_016935.1|WP_014369068.1|1764378_1764978_-|hypothetical-protein
MNFNLYDPNYALYTHPYPRNFYPCSCWYGDYTHPQDRDYPIYNNDGEQYPYYPSQVLIPTRQYNVTLQNQGNSPYKNWYLDIDGNTGRVILSENQFSGVFWSLTNHGNGIVTIQNQGNSHYKNWYLDIDGNTGQVILSQNQFSGVFWRVSNHGNGIVTLQNQGNSPYKNWYLDIDGNTGRVILSQNQFSGVFWNLTRST
>NC_016935.1|WP_014369078.1|1776449_1777904_-|YheC/YheD-family-protein
MIQPWQVIPSPGDGRRSVGILTARTEGLPPFDNRGFYRRLIRAGRPLGLSVFVFTPHDLPEGDDVITGYRYNEAARRWERTDCPLPALVYDRCFSLSREASALYRAALRRLQAEPGVQLLGSPLPGKWDVHRHLERDGRFTALLPRTEPLTPRALAAWLQEHGEVLLKPQAGSQGRGVLHVRRGALRAGAQPSRTGEAAEAAYSVRGRDARGREVSRGFADAAALGQWLRGFVRGRRYLLQQYLQLQTEAGAAFDVRALVQKDGSGRWQLTGTAVRQAPAGSVTANLHGGGTAAPAEAFLAGRFGAQRGAALHRELCRLAAELPEALEAGYGRFAELGIDFGVDRDGRLWLLEVNSKPGRSVFTLLGDARAAEAALLRPLQYAASLLPAAGRGAGHGMQRAAAPPAPAALAALHADALPPAAAHASLLADASPPAAAHASLLADASPPANRPGFRPSAARAPRPLPWIADRVTKPAAAVSSADD
>NC_016935.1|WP_014369079.1|1777934_1779302_-|YheC/YheD-family-protein
MKRTKVKIQIQSSGLSSDGSVVMLSEAVAKKWKIPFQQTLQLRFGSSRQDVRVVPLSQAGALRISGALASRWGLFKDDQLCLQYKSSSRTLVLGPLIGVMVSRVHPGSPDKMFGVNTAFCRELTDACRLYGASVFFSTPDDLQGQGDTVKGWRYTGTWERMTFPVPNVLYNRLTSRKLENLENVQQFVGHAKTRYNAVMFNEKYLNKTEVFDALRKETGLGTYLPESHLLRSFTMLKSMCAKHPTVFLKPITGSLGKGIIRVRRQPEGSYLCHFTSLNGARKQSFSTLTQLFNTIAGKVKTQKYQIQQGLNLLTVGGRPVDFRALVQRGDTGQWGITSIVARIAGSQHFVSNLARGGSLSTVKDALARSGSAAASGGLPKLRRAALSIAKGIESQVPGHFAELGIDLAIDTAGRVWLLEVNSKPSKEDNTPLDTERKIRPSVKGLVQYARFAAKF
>NC_016935.1|WP_164923372.1|1779680_1779857_+|hypothetical-protein
MAVQKENGRTISYGDARASGGLSVFSKKFDEAFFYDGDDLGVSLRGRETGFRLWVPTA
>NC_016935.1|WP_187297999.1|1779884_1780091_+|hypothetical-protein
MEEAADRYLPMRELRGLRELTVPENLDGWCYTYRIRIGSQWDEAPDPYAKAVGINGERSVTGGNGRAA
>NC_016935.1|WP_014369080.1|1780589_1781198_-|TetR/AcrR-family-transcriptional-regulator
MNPIKEDRRVRKTRRAILDALLSLTREQGLHAVTVGGITERADINRATFYAHYRDKQDLIEQAVSEVLSEWGTVEEHRWAGSGSEVDFDRLLPIFTHMFEKIGKHAEFYRIMLGPGGYPGFSENLRDVMCRLIRHGHHRVLELKGARPLVDPDIYLSYVTSAQLGVIIHWLHQETPHPPEYMAEQLMLLYRLGAVQAADYEG
>NC_016935.1|WP_014369081.1|1781453_1782665_+|FAD-dependent-monooxygenase
MSKLKILIAGGGLGGLCLAQGLTKAGVDCEVYEMDPGVLQAGYRLHMNGDGGGALRACLPEPLYELYMQTSRTNPRRELAVMIDSRGVEKAVRPHIGPPNDPVRPHTAVNRRTLRQILLSGLEDRVHFGVEALRFEQDRKGVRLHLADGRVAEGDLLVGADGINSIVRRGLMPEAEPVDTGMRMIYAKSPLTPEIAASLPEVLFDGFIGATDASGAFAGIGAFIPRRPIAEAAAELAPGSVIDPVEPYMMIALSRGFAPLPLSDRELREASRERLYAMMLGLTEDWAPALRGLFERIRVSSIFPQSVRVLKPQEPWRAGRATLLGDAIHAMPPTFGAGANLALKDGAELAARLIRAEAGELTLTEAVADYEEAMRGYAYPILEMSVNPSYKTDFSKGPGGRAV
>NC_016935.1|WP_013914989.1|1784188_1784647_-|MarR-family-transcriptional-regulator
MDNKEYQLSDSLGYLLGNAYRLMSCRLGARFRERQYDVTIEQWPLLAQLWNQDGLTQAQLSALTRKDQPSVSRLVDNMIKKNLVVRVSHPEDRRKNRIHLTPKGAELQQKLIVEALANNADAIAGVSPEEYAVFRSVLERITANMKQMKEEL
>NC_016935.1|WP_013914990.1|1785348_1786176_-|HAD-family-phosphatase
MIKLIVSDLDGTMLLHEERQARTEDIDALKEAAAAGIAVAFASGRMHPEIQAVMEIFGMRTHSISQNGAYVHTQDGQLVQSSAFDTGLIKELAGAAAGTSLLTVLAAPESYVVQEWSEAAEALKPRLMAPLVEMPDLLEKLGDELVCGKLSYMGELAELKRLQEKLLARYGEIVDAYISDIDCLDVMPRTTSKGTGLKALLAVLGLTQEEAVCFGDSFNDLPMFAATPHSFAMGSAHPDVQAKAARTVPFVADALKWVRAYNAAGAQHPDAASSV
>NC_016935.1|WP_013914991.1|1786172_1786949_-|DeoR/GlpR-transcriptional-regulator
MYQEERLLAILQHMRHHHRISVEEICELFQVSRDTARRDIVKLEEQGHILRTRGGAILPSLNKDVPRFDDRLEAEKAVKEDIGRAAASLLQNGDYLFMDSSTTVLQAANHLTTADHVIVTNSFDIAGVLSHRPSTTVHLLGGVVHPRHRFIYGARTLEMLRDYQVDKLLIGTSGITESGLTNPYEEEGYVMKEMMRRADQIIVLADHTKFGQRQFFRLAGLEAIDILITDREPEAPMKQALLEHDIHIIITSEGEKES
>NC_016935.1|WP_013914993.1|1787588_1787870_+|hypothetical-protein
MGKGTRSVIYLGLSLGMLLFAVPRLDLAGGWSLPAVFGVVWCAFALLLVAAHLHELLGVEEETKRELLKVKRMKRWQLEQAVRGRRKMLQVRK

Crispr_ID: NC_016935_4

• CRISPR_ID: NC_016935_4
• CRISPR_location: 1809414-1809532
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_016935_4

Consensus_repeat	Method
GGCGGCTTTGCCGACCCGGGAAGAGCAGAACGAA	CRISPRCasFinder

spacers of NC_016935_4

>4.1|1809448|51|NC_016935|CRISPRCasFinder
AAGCGGGAACAACGGGAAGAGCGGGGAAACGGAAGAAGAGCGGAATACACA

CRISPR arrays and Neighbor proteins around NC_016935_4

CRISPR arrays

The CRISPR arrays of NC_016935_4

>merge|NC_016935|4|1809414-1809532|CRISPRCasFinder
GGCGGCTTTGCCGACCCGGGAAGAGCAGAACGAAAAGCGGGAACAACGGGAAGAGCGGGGAAACGGAAGAAGAGCGGAATACACAGGCGGCTTCGCGGACCTGGAAAGCAAAGAACAGA

>NC_016935|4|2|1809414-1809532|CRISPRCasFinder
GGCGGCTTTGCCGACCCGGGAAGAGCAGAACGAA	AAGCGGGAACAACGGGAAGAGCGGGGAAACGGAAGAAGAGCGGAATACACA
GGCGGCTTCGCGGACCTGGAAAGCAAAGAACAGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016935.1|WP_013915015.1|1814846_1815824_+|bile-acid:sodium-symporter-family-protein	unknown	unknown	gnl|CDD|223462
NC_016935.1|WP_013915008.1|1807624_1808920_+|NADP-dependent-isocitrate-dehydrogenase	unknown	unknown	gnl|CDD|180792
NC_016935.1|WP_013915002.1|1797506_1798433_+|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta	unknown	unknown	gnl|CDD|235547
NC_016935.1|WP_014369096.1|1819880_1820963_+|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl|CDD|223745
NC_016935.1|WP_014369091.1|1812449_1813034_-|5'-deoxynucleotidase	unknown	unknown	gnl|CDD|378993
NC_016935.1|WP_013915007.1|1806257_1807370_+|citrate-synthase	unknown	unknown	gnl|CDD|184467
NC_016935.1|WP_013915000.1|1796535_1797030_+|phosphatidylglycerophosphatase-A	unknown	unknown	gnl|CDD|224186
NC_016935.1|WP_013915016.1|1815910_1817713_+|PAS-domain-S-box-protein	unknown	unknown	gnl|CDD|380161
NC_016935.1|WP_013915006.1|1802013_1804113_+|RNA-degradosome-polyphosphate-kinase	unknown	unknown	gnl|CDD|235469
NC_016935.1|WP_014369097.1|1821166_1823005_-|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl|CDD|223910
NC_016935.1|WP_014369090.1|1811837_1812266_+|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_014369092.1|1813280_1814819_+|fumarate-hydratase	unknown	unknown	gnl|CDD|377546
NC_016935.1|WP_041619064.1|1801431_1801875_+|acyl-CoA-thioesterase	unknown	unknown	gnl|CDD|223894
NC_016935.1|WP_014369084.1|1799395_1801153_+|pyruvate-kinase	unknown	unknown	gnl|CDD|235784
NC_016935.1|WP_014369098.1|1823249_1824164_+|phosphate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|270371
NC_016935.1|WP_013915003.1|1798422_1799403_+|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha	unknown	unknown	gnl|CDD|235580
NC_016935.1|WP_014369088.1|1809560_1810502_+|malate-dehydrogenase	unknown	unknown	gnl|CDD|180477
NC_016935.1|WP_014369094.1|1817822_1818545_+|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|223816
NC_016935.1|WP_014369083.1|1792357_1796320_+|DNA-polymerase-III-subunit-alpha	unknown	unknown	gnl|CDD|235868
NC_016935.1|WP_013915001.1|1797262_1797454_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016935.1|WP_013915015.1|1814846_1815824_+|bile-acid:sodium-symporter-family-protein	gnl|CDD|223462	COG0385, COG0385, Predicted Na+-dependent transporter [General function prediction only].	4.38394e-32
NC_016935.1|WP_013915008.1|1807624_1808920_+|NADP-dependent-isocitrate-dehydrogenase	gnl|CDD|180792	PRK07006, PRK07006, isocitrate dehydrogenase; Reviewed.	0
NC_016935.1|WP_013915002.1|1797506_1798433_+|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta	gnl|CDD|235547	PRK05654, PRK05654, acetyl-CoA carboxylase carboxyltransferase subunit beta.	9.77981e-164
NC_016935.1|WP_014369096.1|1819880_1820963_+|Gfo/Idh/MocA-family-oxidoreductase	gnl|CDD|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	2.1797e-85
NC_016935.1|WP_014369083.1|1792357_1796320_+|DNA-polymerase-III-subunit-alpha	gnl|CDD|235868	PRK06826, dnaE, DNA polymerase III DnaE; Reviewed.	0
NC_016935.1|WP_013915000.1|1796535_1797030_+|phosphatidylglycerophosphatase-A	gnl|CDD|224186	COG1267, PgpA, Phosphatidylglycerophosphatase A and related proteins [Lipid metabolism].	1.11805e-38
NC_016935.1|WP_013915016.1|1815910_1817713_+|PAS-domain-S-box-protein	gnl|CDD|380161	NF033092, HK_WalK, cell wall metabolism sensor histidine kinase WalK. This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.	4.12565e-119
NC_016935.1|WP_013915006.1|1802013_1804113_+|RNA-degradosome-polyphosphate-kinase	gnl|CDD|235469	PRK05443, PRK05443, polyphosphate kinase; Provisional.	0
NC_016935.1|WP_014369097.1|1821166_1823005_-|methyl-accepting-chemotaxis-protein	gnl|CDD|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	2.5663e-40
NC_016935.1|WP_014369092.1|1813280_1814819_+|fumarate-hydratase	gnl|CDD|377546	pfam05681, Fumerase, Fumarate hydratase (Fumerase). This family consists of several bacterial fumarate hydratase proteins FumA and FumB. Fumarase, or fumarate hydratase (EC 4.2.1.2), is a component of the citric acid cycle. In facultative anaerobes such as Escherichia coli, fumarase also engages in the reductive pathway from oxaloacetate to succinate during anaerobic growth. Three fumarases, FumA, FumB, and FumC, have been reported in E. coli. fumA and fumB genes are homologous and encode products of identical sizes which form thermolabile dimers of Mr 120,000. FumA and FumB are class I enzymes and are members of the iron-dependent hydrolases, which include aconitase and malate hydratase. The active FumA contains a 4Fe-4S centre, and it can be inactivated upon oxidation to give a 3Fe-4S centre.	5.29987e-94
NC_016935.1|WP_041619064.1|1801431_1801875_+|acyl-CoA-thioesterase	gnl|CDD|223894	COG0824, FcbC, Predicted thioesterase [General function prediction only].	6.34848e-44
NC_016935.1|WP_014369084.1|1799395_1801153_+|pyruvate-kinase	gnl|CDD|235784	PRK06354, PRK06354, pyruvate kinase; Provisional.	0
NC_016935.1|WP_014369098.1|1823249_1824164_+|phosphate-ABC-transporter-substrate-binding-protein	gnl|CDD|270371	cd13653, PBP2_phosphate_like_1, Substrate binding domain of putative ABC-type phosphate transporter, a member of the type 2 periplasmic binding fold superfamily. This subfamily contains uncharacterized phosphate binding domains found in PstS proteins that serve as initial receptors in the ABC transport of phosphate in eubacteria and archaea. After binding the ligand, PstS interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The PstS proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	3.11256e-92
NC_016935.1|WP_013915003.1|1798422_1799403_+|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha	gnl|CDD|235580	PRK05724, PRK05724, acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated.	0
NC_016935.1|WP_014369088.1|1809560_1810502_+|malate-dehydrogenase	gnl|CDD|180477	PRK06223, PRK06223, malate dehydrogenase; Reviewed.	0
NC_016935.1|WP_014369094.1|1817822_1818545_+|response-regulator-transcription-factor	gnl|CDD|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	7.17047e-89
NC_016935.1|WP_013915007.1|1806257_1807370_+|citrate-synthase	gnl|CDD|184467	PRK14034, PRK14034, citrate synthase; Provisional.	0
NC_016935.1|WP_014369091.1|1812449_1813034_-|5'-deoxynucleotidase	gnl|CDD|378993	pfam12917, HD_2, HD containing hydrolase-like enzyme. This is a family of bacterial and archaeal hydrolases.	1.62245e-96

Protein sequences

>NC_016935.1|WP_013915008.1|1807624_1808920_+|NADP-dependent-isocitrate-dehydrogenase
MAQFEQYALPTEGERITITNGVLNVPNNPIIPFIEGDGTGPDIWAASKRVLDAAVEKAYNGEKKIAWYEVFAGEKAFNKYNNWLPADTLTAIREYIVAIKGPLTTPIGGGIRSLNVALRQELDLYVCSRPVRYFKGVPSPVKRPELVDMVIFRENTEDIYAGIEWAAGSEEVKKVLAFLQNEMGVKKIRFPETSGIGVKPVSSEGSKRLVRAAIEYAIKHNRKTVTLVHKGNIMKFTEGAFKNWGYELAEEEFGDKTFTWAQYDRIKEESGADAANAAQKAAEAEGKIIVKDAIADIALQQVLTRPTDFDVIATLNLNGDYLSDALAAQVGGIGIAPGANINYVTGHAIFEATHGTAPKYAGLDVVNPGSVILSGVMMLEHLGWLEAAELIYKGMETAINNKTVTYDFARLMEGATEVKCSAFADQIIANF
>NC_016935.1|WP_013915007.1|1806257_1807370_+|citrate-synthase
MTATKGLEGIVATTSSISSIIDGVLTYRGINIDDLAENATFEEVVYLLWYGKLPNRSELNQLIQDLSSSAAVPAEVLDGIKLFPKNVNTMAALRTAVSSLALYDAEANDMTPESNLRKAIKLQAQLPTIVAAFARIRQGQEPIAPKSGVSIAENFLYMLTGRNPEKIAIEALDKALVLHADHELNASTFAARVTVATLSDIYSGVTSAIGALKGPLHGGANEAVMAMLEEIGTASNVTAYINEKLANKEKIMGFGHRVYKNGDPRAKHLMKMSEELGKITNNMNWYDMSIQIEELVTGQKGLKPNVDFYSASVYTSLEIPRDLFTPIFAISRTSGWTAHILEQYENNRLIRPRAEYTGPSHQAFIPIEQR
>NC_016935.1|WP_013915006.1|1802013_1804113_+|RNA-degradosome-polyphosphate-kinase
MKETAPREAAAANHYLNRDLSWVEFNWRVLEEAQDPTTPLLERVKFLSIVSSNLDEFMSVRVAGIVDQIKAGYTKKDFTGYTPAGLFKRVMKRAAKMVAEQYRTSREITRALAREGIILTSYDELNATQRKAMDEYYHEIVFPVLTPMAVDQARPFPLVHTQSLYLAVVLMKEGEDPEVEPYFAILQVPSNLNRFIEVPCRTNSKKHEYILLETLIEHHIHTLFSGYTPVSVHGFRLTRNADLTLNEEGAEDLLEEIEIQLRRRRWGAPVRLEVQRGIHPYALQQLIEEFEISDNIFEIDGPIDLTFFMKLSGSLQGYDHLRYPPIKPVYPAELENEDDLFLKLRQQDVLVYHPYESFDAVTDFVTQAAHDPHVLAIKMTLYRVSGNSPLIQGLAQAAESGKQVTVVVELKARFDEERNIAWARKLEQSGCHVVYGLVGLKTHAKITLVVRQEPDGLRRYVHVGTGNYNDNTAKLYTDVGLFTTDKIIGEDASALFNEVTGYSAPHNWKAFGVAPTDLMDKLIEKIRREARNASEGKPARIIAKFNSLSNQQMVDELYAASQAGVKIDLIIRGVCCLRPGVPGLSENITVRSIVDRFLEHSRIFYFENGGSEEIYLASADWMTRNLTRRVELMCPAFNKGIQQSLTRILQLNLDDNVKARQLQSNGMYERMTPAAGEPPLRSQFEAMRISSWKTKAREF
>NC_016935.1|WP_041619064.1|1801431_1801875_+|acyl-CoA-thioesterase
MKVERDQAQAARWFTHEVRVRYEETDQMGVVYHANYLTWFEIGRTEMIRSLGMPYQTLEARGLLLPLTEAEMKFRLPARYDDWVTIRVRVSEFSNLRLTFDCEILRGEDLLVTGRTKHVWLNRDWRPTRIDKEAPDLYALIKASSEC
>NC_016935.1|WP_014369084.1|1799395_1801153_+|pyruvate-kinase
MRKTKIVCTIGPVSESLEMFKKLINAGMNVARLNFSHGDFEEHGNRIKNVRQACQELGKSVAILLDTKGPEIRTGKLKDDQKVELVQDNLITLTTEEIVGDAERVYITYKDLYKDVRVGSTILIDDGLIGLTVEDIRGTDIVCRIKNGGLLGGKKGVNVPGVKINLPGITEKDANDIIFGIQQGVDFIAASFVRKASDVIEIREILERHNANHIQIISKIENQEGVENLDEILEVSDGLMVARGDLGVEIPAEDVPIVQKAMIKKCNQAGKPVITATMMLDSMQRNPRPTRAEASDVANAIFDGTDAVMLSGETAAGKYPVESVQTMARIAERAEAALEHREIFIRQSNAQQTTVTEAISQAVANSALDLDAKAILTATESGYTARMVSKYRPKAPIIAVTPDERVLRRLSLVWGVVPIKGEMCTSTDQLFEHAVDTSLKAGLVSLGDLVVITAGVPVGRSGTTNLIKVHQIGEMIAKGQGIGTQIATGKVVTARSAEEAVAKTSEGCILVTVTTDKDYMPAFEKAAAVITETGGITSHAAVVGISLGKPVIVGVEKALEILKDDAEVTLYPEVGVIYSGRARVL
>NC_016935.1|WP_013915003.1|1798422_1799403_+|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha
MASEMPFEQPLVELRAKIEELRKFSSDKQIDFSDEIARLEQRLQQLESELYAGMSTKHKMQVARHPQRPTTLDYIQHLFTDFMELHGDRLYGDDLAIVGGIARFNGIPVTVVGHQKGKDTKDNIARHFGCPHPEGFRKALRLMKQADKFRRPIITFIDTKGAFPGNAAEERGQGEAIARNLMEMAAMRVPILCVVIGEGGSGGALALGVGNRVFMLENAIYSVISPEGAASILYKDASKSMEAAEAMKITADEILKLGVIDGIIPEPKGGAHRDPAAQAESIKDALWNALQELMAMSEQELIEDRYNKFRNIGRFTTIQEGNPNHA
>NC_016935.1|WP_013915002.1|1797506_1798433_+|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta
MQFKDLFQKKRKYATVPSTDRPAQSRVIDGAIDIPEERPRREIPEGLMNKCPKCGTIQYNKELDKNLKVCTSCDYHYKLNAVERIQMTMDEGMFVEYNADLASEDPLGFPDYGKKYAKAVESTGMQDAVITGEGTIGGYPVVVAVMSFDFMGGSLGSVVGEKVAIAVEKAIEKKCPMIIFSTSGGARMQESILSLMQMAKTSAALAKLSEQGGLYVSVITDPTFGGVSASFAMLGDYIIAEPGAAFGFTGRRVIEQTIKQKLPDNFQTSEFNLQHGQVDMVSHRKELRSTLSRLLGMHTIKEEIVHGK
>NC_016935.1|WP_013915001.1|1797262_1797454_+|hypothetical-protein
MWTVIYIAPTAKIADKIKQRLTEEGFLVQVRAINMTKNQFEIVVPEGELEEVQEVLNSILHRS
>NC_016935.1|WP_013915000.1|1796535_1797030_+|phosphatidylglycerophosphatase-A
MTKDPIIECLEKRGVTIDSIAEIVHQLQLPYNPALSKQACVDSVLTVLQKREVQYVLYTGIALDELAEKKLLPQPLQGLMETDASLYGVDETLALGIVHVYGMIGLTSFGYLDKKKIGIIRELNDHSTGIHVFLDDLVAGLAAAASARIAHRHQDELDGQDEGA
>NC_016935.1|WP_014369083.1|1792357_1796320_+|DNA-polymerase-III-subunit-alpha
MGDFVHLHVHSEYSLLDGAARIETLVSRAADLGMTSLALTDHGVMYGAIPFYKACRERGIKPIIGCEVYYTSGSLKQKGTRQDQPIYHLILLAKNLQGYQNLMKLVSVAHLEGYHYKPRIDPEHLRKYSEGLICTSACLGSEVSQHLLHGRYDDAKAAAERYRDIFGEDFFLEVQDHGLTEQKKVNQDLIRLGRETGIPLVATNDVHYVYEPDHAMQDILICIGTGKTVEDEDRLRIHSSQLFLKSAEEMGRLFPHIPEAIENTLVIADRCGLELEFGRSILPQFDPIPEGLTAGDYLTQLCRTGLQERYAPLSEWGDEAWRRNVEARLDYELGVIERMGYSDYFLIVWDFIRFAHEEGIVTGPGRGSSAGSLVAYVLKITDVDPIRYNLLFERFLNPERVSMPDIDIDFSDLRRDEVIDYVVRKYGRDRVAQIITFGTMAAKAAVRDVGRALNLPYNDVDKAAKLIPGQLGMTLEAALRSSPELKALADRQPKTAELLEMAMKVEGMPRHASTHAAGVIISREPLTQYVPLQEGTEQTALTQYPMEHLESIGLLKMDFLGLRTLSIIERSLEWIRERTGRTIDWKGVSMEDPLTYEMLGRGDTTGVFQLESPGMRRVLRELRPSGFEDIISVLALYRPGPMEFIPQYIRCKHGQQEVEYPHPVLEGILKDTYGIIVYQEQIMQIASLMAGFSLGEADLLRRAVSKKKREVLDEERAHFVEGSRGQGYTEAEANRVYDMIVRFADYGFPRAHATAYGVLAFQTAYLKAHYPVDFMASMLAAVTGSHHKVAEYSDDCRKMGIAVLGPDVNESGVLFTPVGAHRTADGAASGKMEAPADQEGVRQESASGHGAIRFGLAAIKNVGTNAIESIIKERRSGPYQSLIDFCRRIDLRVCNKRVLESLIQAGALDSLPGHRSQLLAMLEDAVDAAVKWRKDRDDLQLVLDGFVEEVSWEVEYPAVAPYSMTQKLELERELLGLYISGSPLDDYEDVLRRMEPDSLAQLPQYPDGSEVKVAGLVMSSKTIVTKKGQPMAFMELEDRVGKSEVVLFPEVWKRAAPVVQKGRPVLVLAKLQLGDEDFKLLADQVVALDDPQLEQKAAKPAGGGYARGGAGRSTPAAGRPPQAAAAAGRTAAPAGGPPQGARPGSSGAAAAPQRSAAGSSGAAAAPQRPAAGSSGAAAAPQRSAAGSSGAAAAPQRSAAGTAPRQAPAAPASGRTPAAQPAPRPAAPARGQAGPGGSAPAPRTAAVQRVYMRISPKHEEPAVLAELKRLITEHGGPLPVVLYYESSQKTLGLSDQYQVKPSPELFHRIEELLGKDSVRVK
>NC_016935.1|WP_014369088.1|1809560_1810502_+|malate-dehydrogenase
MAIQRKKITVVGAGFTGATTALMLAQKELGDVVLLDIPQLENPTKGKALDMLEASPVQGFDAKIIGTSSYDDSASSDIVIITAGIARKPGMSRDDLVNTNAGIVKSVCENIKRTSPQSIVIILSNPVDAMTYVAFETLGFPKNRVIGQSGVLDTARYCTFIAQELNVSVEDVRGFVLGGHGDDMVPLVRYSNVGGIPIEKLIPADRIDAIVKRTRTGGGEIVNLLGNGSAYYAPAASLVQMTEAILKDKKRIIPAIALLQGEYGYDNLFMGVPTLLGGDGIEKVFELELLPEEKAALDKSAESVRNVIKVVTG
>NC_016935.1|WP_014369090.1|1811837_1812266_+|hypothetical-protein
MSQVFLYLHVLGAALMGFYLALPFLAARVEALPNGSAQHGFLSVLFSLNRAGQLALIIAFISGGYLVGKGGYPAIWWILAIVLLLAIGAVSGILGGKMRKALSDANGSSIKAQIGAIRTLSSVAGILYFLVITLMLFPNVFA
>NC_016935.1|WP_014369091.1|1812449_1813034_-|5'-deoxynucleotidase
MESHFFAYLYRLRFIERWSLMRNTMKENVAEHSFHVSLLTHVLCTIANEVYGRQVPTDKVVSMALFHDSTEVFTGDIPTPVKHHNPKILSNFREIEHLAAERLLDMVPEPLRRVYEPLIDPKKTTEDAELKKYIKAADSLDAYLKCVTELSAGNREFAVAKKQIEDTLQEMAMPEVDYFLKHLAPSLEKTLDEL
>NC_016935.1|WP_014369092.1|1813280_1814819_+|fumarate-hydratase
MQHFQESMYKLIVETSTNLPADVRQAIQAAREQEDAGTRSALSLSTIADNIQMAECNVSPICQDTGMPTFIVHCPVGANQIEMKKAIIAAVAQATKDSKLRTNSVDSLTGANSGDNIGPGTPVIHFEQWERDEIEAKLILKGGGCENKNIQYSLPAELEGLGKAGRDLDGIRKCILHAVYQAQGQGCSAGFIGVGIGGDRTTGYELAKHQLFRAADDVNPHPELRKLEEYVMENANKLGIGTMGFGGQVSLLGCKVGVMNRLPASFFVSVAYNCWAFRRQGVLIDANSGEITEWVYTKGETVPMQKDEPAAAAAAPSERREVVLQTPVSEEQIRQLKVGDVVIINGPMHTGRDALHKHLMDHDSPIDLNGAVIYHCGPVMAKDEQGGWVVKAAGPTTSIREEPYQGDIIKKFGIRAVIGKGGMGAKTLKALQEHGAVYLNAIGGAAQYYAQCFKKVEGVDFMEFGIPEAMWHLQTEGFAAIVTMDSHGNSLHADVEQESREKLAQFKEPVFS
>NC_016935.1|WP_013915015.1|1814846_1815824_+|bile-acid:sodium-symporter-family-protein
MRLNAVIEKYLSLIVPVSLILGFLLSRSFNGSAALVPYLFGYLTFVMATGCSWKQIREAFRMPVPMLLTFGLCHVLAPMIGYLIGTAAFGEGSPYVVGFVMFSVIPLGVSSVIWVGLSKGHVPLTLAMIVIDSALSPLVIPAAIEAFFGTTIAFDHTKVMMDLVQIIVVPTILGVLVNELSKGRFKGWSAPVCGPTSKLAMVIVVMINAAVIQPYVMEMKADMLTVVPLVFLLVAVSYALGFFGSLWLRKTDIIISVTYSSGMRNISLGLVLALAYFEPLTAVPVVLSILIQQPMASVNRWCMKLYGQSRLYKKITGAPQSGPLR
>NC_016935.1|WP_013915016.1|1815910_1817713_+|PAS-domain-S-box-protein
MKKFRARLTLIFIILIGSSVLTAGIFMARMLQQSYIESLTASMERELRVIKATTDWRQSGSEPELFRFYSDRAAMLRASADARLTFIRSDGKVLGDSDHDPALMENHLEREEIREASASKLYGSAIRYSSTVQRNLLYVAVPLLEGENVTGYLRMAMSLEDVEGSIRQVWFVLTGMLLAVFVIAGLISYRVAYSVTRPIELITSVARQITDMNYKYRVQVNKRDEIGQLGHAINRMADSLELQMNRISEDENRLKSVLESMTSGVIMIDREGKIALLNRSAEEILGFSAKELLGKSFNQAKQQYEFTQLIQECIDVRDHIRDEVIFYYPKERILEINLNPIAEAGGEWEGLLIVLHDITAVRRLERMRSEFVANVSHELKTPIAAVKGFAETLLAGALNDKETARSFLQIIFDESERLNRLIGDILELSKIESKRIPLQFSPVHLEPFIGNCVHVMNTEAKKKGIELELNVDGDFYMEADEDRLRQILINLLSNGISYTPEGGRVRLKVEQLVSGKEVTEHDKVRFTIADTGIGIPKKDLPRIFERFYRVDKARSRSSGGTGLGLSIVKHLVELHKGTIRVESEVGVGTKFIIEMPLIHN
>NC_016935.1|WP_014369094.1|1817822_1818545_+|response-regulator-transcription-factor
MPQKILVIEDEPTLARLLSYNLTQEGYETKVVDHGSDGLQAALQQYFDLIILDIMLPGMNGFEILSKLRQKGNKTPVIILTARNAEEEVVQGLKYGADDYITKPFGVAELLARVSAVLRRTMTEDGTQEKAGTGEKVISAGDLFIYPEKYEVLLGGESIPLRPKEFEVLLYLVQRPGVVVTRDDLMNIVWGFDYIGGQRTVDVHVSSLRKKLEMNQQSVQIESIRGVGYKLVTSMGALKK
>NC_016935.1|WP_014369096.1|1819880_1820963_+|Gfo/Idh/MocA-family-oxidoreductase
MSKVYRIGIIGCGGIANGKHMPALKNQPNAEMVAFCDIVEERAQEAKNAFGTPDAKVYTDYKELLADGSLDIVHVCTPNDSHADISIFALESGKHVMCEKPMAKTAADARRMVEAAKRTGKKLTIGYQNRFRSDSQYLKRVCADGELGEIYYGKAHAIRRRAVPTWGVFLDEEKQGGGPLIDIGTHALDLTLWMMDNYKPKAVLGTAFHKLAKKADAANAWGSWDPEKFTVEDSAVGMITMQNGATIMLESSWAINLVKTGEAKTTLCGTEGGADMEDGLRINGEKHSKLFTNHIELDGRGVDFYEGSKDNPADLEAKLWLQAIENDTEPVVTPEQACVVSEILEAIYESSKTGKAVYFD
>NC_016935.1|WP_014369097.1|1821166_1823005_-|methyl-accepting-chemotaxis-protein
MLYTQGWTLKRKLIAGMTGVIALFLCAALLNLYQVGRIKEQLRLQNDKVELKQAALELKESVQELNIIASGLEISRKTEYIPRYNEERQAFEAHLKRIGDTADTEEKALWRSKLILLTGEYTNTFDVAAALITQNSLSEKDLAANMEYLYNESQTLMKEIFLYVDMFFITYSEDADSAVASTLQRLDRTVGLLLAALAVSVVLSAVVLTLLLRSFLPPVRRLQEAAARIAAGDLRHRIRSTAQDELGQLSTAFDHMADAVRTMLAHTRDAAGALAEHSLSFREYAGTTAAANQEIVSAIDDISAGAQEQARHAEAAAALLSGLAEAMHSMTGSMEDIREMSRTSALQTEAGAASTEALGSSAARSAEVLEKVGSALRSLTGSSAEIADLSGRVAGMAAQTQVLSLNATIEAARAGEYGRGFSVIAGEVRQLAEQSRASSLSVGKVVGSLQTQIQDVEASLSEVLATFGRQHSDVQDSIAAFGAIREAMAELAGRIDRVHGLTAEARQKNLQLVEAVSAVAGIARDTAAGVQEVAASSQGQDASIRRIASRSDDILSLAQRLQSELEKFSIGEDEGVAAEAAGEIPAGPRAAGSGSDETAAPPLKETPLKSAG
>NC_016935.1|WP_014369098.1|1823249_1824164_+|phosphate-ABC-transporter-substrate-binding-protein
MLKQLSKKSLNVAMIMVLSVGVLAACGQKTEQTQPTPPATGAGTDKGATPPAAATPIEGTVTASGSSALLPLVKAAADEFMKNNPKVTINPTAGGSGKGLKDVADGTSNIGNSDIEAGPEYKDKGLVDHVVAIAPFALIVNKDVTIDNLTKAQATDIFTGKIKNWKEVGGPDKNIVVVHRPDSSGSRALVKKIVLDGQEFTKDGVTQESSGAMATTVGQTPGAIGYVDTPYVKDPIKALKFEGVEFSKDNIKGGKYPLYGVEHMYTKGEPTGATKAFLDFIMSPEFQGKRVEELKFLPADLLKK

Crispr_ID: NC_016935_5

• CRISPR_ID: NC_016935_5
• CRISPR_location: 2002749-2002843
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_016935_5

Consensus_repeat	Method
TGTATCATTTTGAAAGCGACCTTTGTGC	CRISPRCasFinder

spacers of NC_016935_5

>5.1|2002777|39|NC_016935|CRISPRCasFinder
GGAGCACGAAGGAGCAGCCGAGTTACATACCAGCGAGGC

CRISPR arrays and Neighbor proteins around NC_016935_5

CRISPR arrays

The CRISPR arrays of NC_016935_5

>merge|NC_016935|5|2002749-2002843|CRISPRCasFinder
TGTATCATTTTGAAAGCGACCTTTGTGCGGAGCACGAAGGAGCAGCCGAGTTACATACCAGCGAGGCTGTATCATTTTGAAAGCGACCTTTGTGC

>NC_016935|5|3|2002749-2002843|CRISPRCasFinder
TGTATCATTTTGAAAGCGACCTTTGTGC	GGAGCACGAAGGAGCAGCCGAGTTACATACCAGCGAGGC
TGTATCATTTTGAAAGCGACCTTTGTGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016935.1|WP_013915185.1|2002952_2003936_+|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl|CDD|224525
NC_016935.1|WP_013915173.1|1988212_1988701_-|cytochrome-c-biogenesis-protein-CcdC	unknown	unknown	gnl|CDD|377808
NC_016935.1|WP_014369212.1|2005156_2005774_+|DedA-family-protein	unknown	unknown	gnl|CDD|223659
NC_016935.1|WP_041616610.1|1994279_1994441_+|XapX-domain-containing-protein	unknown	unknown	gnl|CDD|274620
NC_016935.1|WP_148279672.1|2003974_2004949_+|carbohydrate-kinase	unknown	unknown	gnl|CDD|238572
NC_016935.1|WP_013915180.1|1996289_1997837_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|226364
NC_016935.1|WP_014369213.1|2006074_2007208_+|acyltransferase-family-protein	unknown	unknown	gnl|CDD|226446
NC_016935.1|WP_014369209.1|2000651_2002157_+|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl|CDD|214599
NC_016935.1|WP_013915192.1|2011451_2012834_+|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl|CDD|274368
NC_016935.1|WP_014369203.1|1988806_1989751_-|EamA-family-transporter	unknown	unknown	gnl|CDD|273359
NC_016935.1|WP_014369207.1|1997833_1998955_+|ABC-transporter-permease	unknown	unknown	gnl|CDD|226962
NC_016935.1|WP_013915191.1|2010777_2011455_+|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|223816
NC_016935.1|WP_014369204.1|1989982_1991809_-|APC-family-permease	unknown	unknown	gnl|CDD|372624
NC_016935.1|WP_014369206.1|1994995_1996147_+|BMP-family-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|380618
NC_016935.1|WP_014369216.1|2018996_2021582_+|EAL-domain-containing-protein	unknown	unknown	gnl|CDD|236645
NC_016935.1|WP_013915189.1|2007458_2007848_-|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_013915183.1|1999958_2000444_+|nucleoside-deaminase	unknown	unknown	gnl|CDD|238612
NC_016935.1|WP_014369215.1|2016852_2018955_+|cellulase-family-glycosylhydrolase	unknown	unknown	gnl|CDD|365907
NC_016935.1|WP_014369205.1|1992378_1994031_-|family-14-glycosylhydrolase	unknown	unknown	gnl|CDD|366599
NC_016935.1|WP_014369214.1|2012955_2016753_+|S-layer-homology-domain-containing-protein	unknown	unknown	gnl|CDD|336728

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016935.1|WP_013915185.1|2002952_2003936_+|LacI-family-DNA-binding-transcriptional-regulator	gnl|CDD|224525	COG1609, PurR, Transcriptional regulators [Transcription].	8.59934e-123
NC_016935.1|WP_013915173.1|1988212_1988701_-|cytochrome-c-biogenesis-protein-CcdC	gnl|CDD|377808	pfam07301, DUF1453, Protein of unknown function (DUF1453). This family consists of several hypothetical bacterial proteins of around 150 residues in length. The function of this family is unknown. Members of this family seem to be found exclusively in the Order Bacillales.	5.51308e-42
NC_016935.1|WP_014369212.1|2005156_2005774_+|DedA-family-protein	gnl|CDD|223659	COG0586, DedA, Uncharacterized membrane-associated protein [Function unknown].	1.47075e-29
NC_016935.1|WP_041616610.1|1994279_1994441_+|XapX-domain-containing-protein	gnl|CDD|274620	TIGR03510, conserved_hypothetical_protein, XapX domain. This model describes an uncharacterized small, hydrophobic protein of about 50 amino acids, found between the xapB and xapR genes of the E. coli xanthosine utilization system, and homologous regions in other small proteins, such as the N-terminal region of DUF1427 (pfam07235). We name this domain XapX, as it comprises the full length of the protein encoded between the genes for the well-studied XapB and XapR proteins. [Unknown function, General].	6.71793e-06
NC_016935.1|WP_148279672.1|2003974_2004949_+|carbohydrate-kinase	gnl|CDD|238572	cd01167, bac_FRK, Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into glucose-6-phosphate. This is in contrast to FRKs [or ketohexokinases (KHKs)] from mammalia and halophilic archaebacteria, which phosphorylate fructose to fructose-1-phosphate.	3.10844e-106
NC_016935.1|WP_013915180.1|1996289_1997837_+|ABC-transporter-ATP-binding-protein	gnl|CDD|226364	COG3845, COG3845, ABC-type uncharacterized transport systems, ATPase components [General function prediction only].	0
NC_016935.1|WP_014369213.1|2006074_2007208_+|acyltransferase-family-protein	gnl|CDD|226446	COG3936, COG3936, Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism].	7.57728e-40
NC_016935.1|WP_014369209.1|2000651_2002157_+|methyl-accepting-chemotaxis-protein	gnl|CDD|214599	smart00283, MA, Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.	7.98219e-50
NC_016935.1|WP_013915192.1|2011451_2012834_+|HAMP-domain-containing-histidine-kinase	gnl|CDD|274368	TIGR02966, Phosphate_regulon_sensor_protein_PhoR, phosphate regulon sensor kinase PhoR. Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems].	7.8518e-70
NC_016935.1|WP_014369203.1|1988806_1989751_-|EamA-family-transporter	gnl|CDD|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	4.07343e-18
NC_016935.1|WP_014369207.1|1997833_1998955_+|ABC-transporter-permease	gnl|CDD|226962	COG4603, COG4603, ABC-type uncharacterized transport system, permease component [General function prediction only].	1.23066e-105
NC_016935.1|WP_013915191.1|2010777_2011455_+|response-regulator-transcription-factor	gnl|CDD|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	3.16891e-83
NC_016935.1|WP_014369204.1|1989982_1991809_-|APC-family-permease	gnl|CDD|372624	pfam13520, AA_permease_2, Amino acid permease.	6.35056e-29
NC_016935.1|WP_014369206.1|1994995_1996147_+|BMP-family-ABC-transporter-substrate-binding-protein	gnl|CDD|380618	cd19963, PBP1_BMP-like, periplasmic binding component of a basic membrane lipoprotein (BMP) from Brucella abortus and its close homologs in other bacteria. Periplasmic binding component of a family of basic membrane lipoproteins from Borrelia and various putative lipoproteins from other bacteria. These outer membrane proteins include Med, a cell-surface localized protein regulating the competence transcription factor gene comK in Bacillus subtilis, and PnrA, a periplasmic purine nucleoside binding protein of an ATP-binding cassette (ABC) transport system in Treponema pallidum. All contain the type 1 periplasmic sugar-binding protein-like fold.	3.11055e-156
NC_016935.1|WP_014369216.1|2018996_2021582_+|EAL-domain-containing-protein	gnl|CDD|236645	PRK10060, PRK10060, cyclic di-GMP phosphodiesterase.	2.34448e-112
NC_016935.1|WP_013915183.1|1999958_2000444_+|nucleoside-deaminase	gnl|CDD|238612	cd01285, nucleoside_deaminase, Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on the substrate. The functional enzyme is a homodimer. Cytosine deaminase catalyzes the deamination of cytosine to uracil and ammonia and is a member of the pyrimidine salvage pathway. Cytosine deaminase is found in bacteria and fungi but is not present in mammals; for this reason, the enzyme is currently of interest for antimicrobial drug design and gene therapy applications against tumors. Some members of this family are tRNA-specific adenosine deaminases that generate inosine at the first position of their anticodon (position 34) of specific tRNAs; this modification is thought to enlarge the codon recognition capacity during protein synthesis. Other members of the family are guanine deaminases which deaminate guanine to xanthine as part of the utilization of guanine as a nitrogen source.	3.34725e-33
NC_016935.1|WP_014369215.1|2016852_2018955_+|cellulase-family-glycosylhydrolase	gnl|CDD|365907	pfam00150, Cellulase, Cellulase (glycosyl hydrolase family 5).	1.78221e-50
NC_016935.1|WP_014369205.1|1992378_1994031_-|family-14-glycosylhydrolase	gnl|CDD|366599	pfam01373, Glyco_hydro_14, Glycosyl hydrolase family 14. This family are beta amylases.	0
NC_016935.1|WP_014369214.1|2012955_2016753_+|S-layer-homology-domain-containing-protein	gnl|CDD|336728	pfam07532, Big_4, Bacterial Ig-like domain (group 4). This family consists of bacterial domains with an Ig-like fold. Members of this family are found in a variety of bacterial surface proteins.	7.12765e-11

Protein sequences

>NC_016935.1|WP_014369209.1|2000651_2002157_+|methyl-accepting-chemotaxis-protein
MGVTSKQIPEPTAAPRVLNEIEGVYLTRNKIMAWLFAGLFALNAVTVLITRGWGFLPLTLLLGATSGILFYAVNKRAGLTKVPFVVVGCFLLLHLILLGIEFSAVNTLILAIFLCLFPSYRYVLTFSVLALVEMNVLSAVTGKLPVGDNLVLHNILLVIALVPLVIMALLSQRLLRSMLVQMKEAEQASLQVSTMFDKVKQAVGILGEFSKELQENSTTTGQITREVSIGFSEIMKGVETQAASVSDISEQLGGSHADIAAVAGSANEMKEISRQTASVTAGGTEQVHDMAVRIQEVERIMDTIVDSMEKLNAQNAAIGTILSSITEIANQTNLLSLNASIEAARAGEQGRGFAVVANEVKKLAESSQKSAEEISGILGSIQGSFISLTEQVGRGKQALGTSKESAKQSETIFSQIADFTQQVVAQASEVEQKTLKIKTSSDHIVQEVSSIAAVTEESTAAFEEISASVENQKQMVERTVASFRQLEELIVDLNKMVSGQE
>NC_016935.1|WP_013915183.1|1999958_2000444_+|nucleoside-deaminase
MTDREKHIPYLRRCVELSLLARESGNTPFGALLAGPDGTILLEQGNIEITGRNCTGHAERTLMEAASKRFSRQELWNCTLYTSAEPCAMCAGSIYWGNVGRVVYGISEKHLAELTGEDEQNPTLDLPCREVFSRGRKPIEVIGPFPEVEEETAAAHAGYWK
>NC_016935.1|WP_014369207.1|1997833_1998955_+|ABC-transporter-permease
MNERHTAPSLQLEQGRGARRSRFRRPYRIEIDPAGGQGPWWVPVVSIVLALAVCGIFIAWNGMNPLTVYAKMVKGAFGTSFGFTETLVKAIPLMLCGLGVSIAYRISVWNIGAEGQFIAGAMAATAVTVYYPELPMVLSIPFMLLASLAAGGLWGLLTAIPRTYFGVNELITSLMLNYVALLALNYVVFGPWKDPKGFNFPGTPMFTEAQSLPVLGATRLHMGLVFALAGVLLYWLVIRYTRWGYELRLIGANAEAARNAGIPISRHILAVMLVSGALAGLAGMSEVAGVTHRLMYGISPGYGYTAVIVAWLAKLNPAGLVISSVLFGGLIVGGYSVQTIGLPSSVSSMLQGAILFFFIAGAMAGKFRLRRSR
>NC_016935.1|WP_013915180.1|1996289_1997837_+|ABC-transporter-ATP-binding-protein
MGSSVFSVEMKGIVKQFGSVTANDHVDFRAKPGEIHALLGENGAGKSTMMCMLSGVYRPTSGEIYIRGKAAGIRSPKDAMRLGVGMVFQNFRLVQTLTAAENIVLGERSGFWRGPGWIRRKQEEIEAISERFGLPFPADRPVWQLSVGEQQRVEIVKTLYRGADLIILDEPTSVLTPGEVDQLFETLARMKSEGKTVIMTTHKLKEVMFASDRISVMRKGRMIAEMEKRETSEGELAQLMVGSRTAPQPAAKLQGSPKAGGPLLVVRGLDVYGDHGRKALGGLGFEVREGEIVGVAGVSGNGQKELAEVLTGLRMWKGGSVEFAGRPLKNGSVRAAIESGIAHVPENRMKSGLAGSLGSVDNLLFKTYRSPKRSRLGILRSGSNRSWAAELVERYDVKTPGIDAPVQMMSGGNQQKLLFAREIEQDPKLMVAVHPTQGLDVGASQGVHRLLGELRSRGRGVLLISEDLDEVLQLSDRVLVLYGGRNVGTVDRAEADRERIGRLMAGLTEREGEAG
>NC_016935.1|WP_014369206.1|1994995_1996147_+|BMP-family-ABC-transporter-substrate-binding-protein
MNRRRRSGVIGLVLTMVMAWALAGCSGGGASTGAGGTADPKSTEPAPTTDTGSKTPRVAFVYIGPPGDGGWTFQHDEGRKQMEKELGIKADTVENVPESADAERVITELAQNHDIVFTTSFGYMDYTLNVAKKFPNVKFEHTAGYKTHANMSTYFGKNFEASYLSGIAAGKMTKKNLIGYVGAFPIPEVIYNINAFTLGIQSVNPDAKVQVVWTNTWYDPTTERQAAVSLLDKGADVLLAYQDSPATLQAAAERGAMAGGNDSDMSRFAPKAYLTNPIWNWGPYYTKTVKSVMDGTWKSQQYMGSMADGMVGLAPLGESVPDDVKKLVEDAKAKILSGELKVYQGPIKDAGGTVKVEAGKELPLSDILQMNWFVQGVEGTIPK
>NC_016935.1|WP_041616610.1|1994279_1994441_+|XapX-domain-containing-protein
MMEAVLSLLAGMVVGVLFTFIRLPLPAPVTIAGVLGVAGVYLGGKLVSLFIRS
>NC_016935.1|WP_014369205.1|1992378_1994031_-|family-14-glycosylhydrolase
MAITTVSTSVLLRKSSAALLSLVVGAGLLAPIPSAEASSISSDYKAYVMAPLTKITDWNAFRNQLITLKNNNVYAVTTDVWWGDVEGAGDNVFDWSYYKTYADTVRAAGLKWVPILSTHQCGGNVGDDCDIKLPNWLWSKGAQDQLTIRSETGFYNKETLSPWWSGTAAQYDELYASFASNFSGYKDIIAKIYLSGGPAGELRFPSYNTADGWSYPSRGKLQAYTDSAKADFRTAMQTKYGTVGALNTAWGTSLASFSDVSPPSDGDNFFTNGYKSNYGKDFLTWYQGVLEKHVKAIGAKAHSRFDSVFGVPVGAKISGVHWQMNNPTMPHSAEYGAGYYNYSTLLDAFKSANLDLTFTCLEMTDAQANTAPYYSAPKSLVIQVSNLANQKGIRLNGENALAIGDAGQYQNVAEMLFNYNFSGFTLLRMSSLVNASGTATSLMSSFRDALAMTPTAVTFVVKGAPTASGDTVYVTGSRWEMGNWTTGVYPLKLTYNSTTADWRGTAYIGSGRNYEFKAIVKNSAGAVTWEPGSNNTLTVPSAASTYTITW
>NC_016935.1|WP_014369204.1|1989982_1991809_-|APC-family-permease
MFASIKRFLIGRPLKSNELGEQKLNKLKALAILSSDALSSVAYGPEQILLVLMTVGAVAFWYSIPIAVGVLILLTALILSYRQIIFAYPHGGGAYVVSKQNLGIYPGLIAGGSLLVDYILTVAVSVSAGTDAITSAFPALHDHTVLIAVAFVIFITLLNLRGVTESASVLAYPVYLFVLALFILIGAGLYNIISGSGPSGVHAPLGTPVAGVGLFLLLRAFASGSSALTGVEAISNAIPNFEDPAPKNAAKTLTAMGLLLGLLFSGIVFLAYYYGITPRPEVTVVSEIAEATFGRNFMYYFIQGTTALILILAANTGYSAFPLLAVNLAQDKFIPRMFTVRGDRLGYSNGIIILGVLSILLIIVFKGQTEHLIPLYAVGVFIPFTLSQTGMMMKWKREKPEGWALKLTINSAGALISLLVTIMFFLTKFTQVWTVLVFLPLIILLFHRIRKHYEAVGDQLRLTTCEPALTIEGNVMILPVAGITHVVENSLNYVKSLAPHQIIAVHIPFDRENEAEFQEKWKAWQPDVRLVTLHSPYRSIIQPLTKFIDTVQRKAGESNYQVTVVIPQFIPKKGWHNILHNQSSLLIRAHLLYRRNVIVTTVPYHLKK
>NC_016935.1|WP_014369203.1|1988806_1989751_-|EamA-family-transporter
MPHQTNSSADSHPSPASLASSKGALYRMIAAMAIFGSVGFAAGRTGLQSFELVFVRCICAVPILGTGWLLSGQFRREAWPVREVLLVLLSGLCLVGNWVFLFRAFEAMPVTVAVSVYYLAPVFVLLLGSLLFRERLKVSSAVSVAVCAAGTALVSGIGSGAPGEVLSGGLLWALLAALLYALVTLLGKGIRRMSPYAVAMLQTAVGVLLLPPLVHFAAFGGLGSSQWLWIALIGAVHTGLVYYLFFGSLRHLPARTISLLAFLDPGIAMLLDMLITGFRPGLLQIVGIVLLFGGMAVPLWDRKDRAAQPSALTE
>NC_016935.1|WP_013915173.1|1988212_1988701_-|cytochrome-c-biogenesis-protein-CcdC
MEALPVLIMIVIVGFVLRRRIRAAARPVTGRGLRLLLPLLILPLGLPGVWNPQLHLTLKEVVLSLLFGLLMSVPMILTTNYERREDGRIYPVKSKAFIVVILALIALRLGLRSYLSALDPAELAMLFYLIAAAYIVPWRIAGFVKFRRIQGAARQEDQGFPL
>NC_016935.1|WP_013915185.1|2002952_2003936_+|LacI-family-DNA-binding-transcriptional-regulator
MAERAGVSTATVSHVINGTRFVSEEAKAKVNRAMEELEYRPNTLARGLRSQKSMTVGLIVPILPSDTSNFFFLTVAQGIQKVLREHGYQLLLSSNMSGTPEEEREQIRLLQSKWIDGLIIAPAAGGTGFPLEPGEDGLSVVFIDRQPQGVSGDCVLGDSFGGAYEAVSLLLEQGHRRIGYIAGEEGITTSSERYEGYRQALADRGLTPDPLLEKSAASSFESGYACAKELLGAGGVTALFVANNVQTMGAMKYIQERGFRVPGELAIIGFDDYDWTRVTTPPLTVIRQPAFELGCRAAEVLLERIGQPDRPPQEYRLKAELIRRDSC
>NC_016935.1|WP_148279672.1|2003974_2004949_+|carbohydrate-kinase
MIMNWDVTALGEVLIDMTPAGTSDKGYPLYESNPGGAPANVLAALSKLGKRTAFIGKVGADGFGTYLRDTLQECEIDTSGLIFTEEANTTMAFVHLSADGDRSFSFFRKPGADRLLEAGEVRGELLAQSRIFHFGSISMTHEPSAEATRFAVSGAKAAGALISYDPNLRMPLWSDAAHAKAMMEYGLGCADVVKISEEELEFLTGLTDLADGSQQLAERFGIPLILVTLAEKGSFYRFGGATGLVPGYAVNTVDTTGAGDAFLGGVLYGLLEKDRRLSELQEEEVRQVVTFANAVGALATTVKGAIPAMPDLAAIRRLMDSAVS
>NC_016935.1|WP_014369212.1|2005156_2005774_+|DedA-family-protein
MTVDTLVAWIEQFGYAALFFSLWLGIVGAPIPDEAIVMTGGAVTAGGLLQPVPTFLLTYLGVVSGLSLGYVLGRYAGGWAVDKLRSKPKLQKHILFSERLVERYGSLALVISYFVPVVRHVMPYLLGMNRMPFSRYAALSYSTGLLWTMLFFLLGRYAGDHADEAVSYLYGYGVKLLWLPCVLAAGLWAVRSVMRRRRLHREDSL
>NC_016935.1|WP_014369213.1|2006074_2007208_+|acyltransferase-family-protein
MSGKKLSYEILLLRCIGCLFVAAVHAVIMTYRIHDPIPNELYRLALNSIRTICSVGTPIFIFITEFLIAKNYKEDLPKQFISKRLKVLIPPYIAMGIIGSLYKVQESGQPFTAYNLGMQSLKNIFLADYNGYFIVIIIQFILIHYLFHYKLKSWPAKIVLPASFLVNFVYLAFFNFVPPFGFSESTGNYIWYYLSWMPFFGWAFYFALGYYCGKHYDKFIETLNRRKWLILAAPLFFGAVLLGTKMLGIPKVNTSKTIWYLFFMPSVTFVIFYLSSKLKSVPNFVVSISDHSFGIYLTHAVIMRVFVLLYKPYFADAPAIVTFVLIYVTCVGLAMAVTNVLNKVPFGKYLVGPVRDNAKAVRKQQGLDAPSVATAAK
>NC_016935.1|WP_013915189.1|2007458_2007848_-|hypothetical-protein
MNLTPTQQLLMEALGRSTDGKIHNGAEYLLKTGLLFEINRRILHPLGLAMRVVIEKHEDGTSEYSFAPYLFDNRDNEVGELFDEDTLRGGEQCLLEFMEDFGVGKMQERLRHLGFIIQRSQEPVRYEHI
>NC_016935.1|WP_013915191.1|2010777_2011455_+|response-regulator-transcription-factor
MITILLVDDDNHIRELMKLSLREEGYRLIEAGDGQAALHCLEEVQVHLVVLDVMMPRMDGFELCRQIRRKYNDLPVLMVTAKGETGDKVEGFQLGADDYLVKPFDPRELIMRVKSLLRRYKLAGSDRIQLGRVELDKKGYEVIRGQEHLTLPLKEFELLHMLASHPNQILTRNQLIEGIWGLDYEGDDRTVDVHIKRLRERFKGEEEGFVIKTIRGLGYKLEVKA
>NC_016935.1|WP_013915192.1|2011451_2012834_+|HAMP-domain-containing-histidine-kinase
MRGSLYTRIVLAFLVSVILGLFIAFYATGLLFAERIWNNMKEDLHFVALDLIDTYQMTNGMDINQYLEARVLTRPFYVSLIDAEGGFREFGYRNVKNKRSVDQEAVKQVLAGGVHYSVLEEGGDEGALLGYPMEIDGRQYALFVQPAAPKMALNIRNAMITALAIELVAGSFFILIGARYLVNPLKLMTRASRRIAKGDFNISLDWKRRRDELGELAVSFTEMAGELKQMERMRQDFVSNVSHEIQSPLTSIAGFSKVLQQRQMPEEERKEYLRIIEAEAQRLSRLSENLLKLASLESEHHPFHPQTYDLDEQLRNVILTMEPIWSAKDIELDLDLPSVKVQGDPDQLSQVWLNLIGNALKFTPESGTVRIAIKTGVDKVQVKVSDTGIGISEEDLAHIFRRFYKADRSRTSANGGSGLGLSIVKKIIELHGGTIAVESRPGEGTEFTVTLPYVLLKRRD
>NC_016935.1|WP_014369214.1|2012955_2016753_+|S-layer-homology-domain-containing-protein
MNSTASSRVKRFTYMIKLLLCTAIVLAGAVPLSLSASAQPLPDLVFFGENPNTSHWGVEVQKENDLLPFDASVAFNGHPAHRVTNVSGGWWGIGMTLQWTTRDISGYIPYGALEFELKGSRGGELLQFSLSDGRSPAAETGSVPAEASASWNHVTIPLAQFPQIGSFPASAWNTLLITKVNGEDLNTLWLSDMKFTSRYITGYEPLILTAPQGTVPAMPSVVTAVYSDSTTTEVPVTWSGVPDGSAAGAFTVQGHVAGVSVQPTAEVTVGTEADQGTGSEEPQPAQETPPAVETPSPETVPSSGQQEHVVFEGVRTDQYFGSGGNLKLETDLVSTSSLPVDSTVEGTYNGQPSYKIAVTKLADPNWGYWNGVLAADGWTSYSLEAFREGTLEFYVKGAAGGEDFVIGIMDTNDVKSVLSLSGLAQTVTTDWSLIRIPLSRFTEQAPDLDLSIIDKVVLENASTQGEMSVWLNRIKFTQNPAAELEIASVDPVKAVTVAGLPPELPQEVPVTYENGTTGTANVSWEAGDGYRVRGRYTVRGTILQDTGPVPVTAEVTVVRALSDEPHVIFLDKKKAQWASAEGHFSLGMEQALDDQGMPVTNEQGNPVMTLPVDPQVTFGGLPAYRLQVTRIPGPNWGYWGTGLTMDNWNPVNLEALYERGSLDFMIKGLAGGESFSVVLTDRAGALGTVKLSDVAAVTTGWRQVSIPLKRLVPVSSAHRLKESTAVTFTSDTGTGAAPLTVWLSDVRLASEASREVVRFGTKLPVQAQQLPQLPELPATAEAVYNDGTTEQVPVAWDAVTFSSWGYPNPVQGTAQGIDLPATLQFTVEGSRSSGSSGSGSGSGSAGMPEEPEAPIAAPVVPAASSLYPNGAAGTYTLPALKPAVDPADALLAVVNVQPGALKEGYKAAAPGPGQRPVMHIKVPYMSGVTGYAVKLPAGAVSGAYPDAELSVTTDLGRVVLPADLLNPDQLNGAAAIRLVIRRSDTADMKKTAREQVGGRTVLDIHLEADGVILPWESREKRVLVSPDYAPTDEELEHPERLVILYLGEDGEAEPVPSGRYDRTGGRMIFSAGHFSRYAVAWGSRTFGDLAGYGWAQEAVELLASRGIVQGTGPAEFAPGRGVTRAEFVSLLVRTLDLAGLPAEADFRDVDPSSPHYQAIAAAARLGIAGGIGGGLFAPDAPVSRQDVIVLTERALERAGRLHAGAADSLPSGVFRDAEDLAGYAVPAVSALYGAGLIEGAGGLLRPEAEMSRAEAAVLLNRIYPY
>NC_016935.1|WP_014369215.1|2016852_2018955_+|cellulase-family-glycosylhydrolase
MLRKPFVPLAALMSALLLLTSAGAAGYAEEAAPGTSQVNAFRAVTAVQAAKAMSPGWNLGNTLDAYPDEGSWNNPPAEETIFEDIRAAGFRSVRIPVTWDSKIGPAPDYIIDPARLDRVEEVVDWALERGLYTVLNVHHDNGNWVTKMAVDPVTGLYVDDYNRNMDKLEKVWKQIAGRFKDKSEKLLFEVLNEPNNGEWEPKIEAPTDPDYPEARHHLTPEELNAMNHRMLKAIRTSGGSNASRIVVIGAEMDNSEKAVAHLEVPDDPYLMATFHYYTPYPFISNSWGHTAWGTPEDKAELTRYFKPVYDTFVRKGIPVLLGEFGTFVDPEAYAKSYYFNAVVRASYKYGFVPMYWDNGLDNYDRKARVWRDETAKDVIVRAGLGEINSFIGMRDAYFPQGKEPGDLVLPLELGGNELTGIYHGYYRLVEGRDYVMNEERTEMTLYGGFIAKLLPARGEAGAKETLRFRFSEGADQPLNLIRFAQPVLQDTKLTIPAGALKENLKIPVQYNGTKLATVRMVDAATGRPVKDEWAQGYVNRGDFVMDAEHVILSKEILNGRPPGSETKIILEFWPKGTTAEITVSAKAVKPEPGYQRKVSVLPRTAPKARRPLTIEGTILSLNGASVYKGVIDVEINDAEGNKVEQRIYNEKTLKPGEPLTVSFTWKPQMRGKYIVKFSYFTTNWKENLFWDDAARIIEVQ
>NC_016935.1|WP_014369216.1|2018996_2021582_+|EAL-domain-containing-protein
MAVPEAAGRKGSVLIYTSFTFLAFLCYFLPVKLVLGTEMVFASFFFLITLRRFGAALTALQVTAVHVSASAFLHEPLLSSLVNTVEIGAVFLLLRTRLRSVLPAAALFWGLFGIPLLLVMYYIRFGTLGAEIGLYTVTLLVSRLFNALMADLIWTYLPHLRKQAKAGGRTGVQLSRLLLHLTLFSVIGSSFLFMVNTGKNAQSNLEAELQEEAAGLTASLSKSYASWSPEQVRALKLHSLIQAGYFRELAVTASQWISDEGLLIGPRGEVIVTYGRGSLGAESDWMRRTEWRPLTPALYEWRTPARLLDIPGNQWQRMAVVAEVPLPPFKLYMKMSTVQHKEEVLGYYLSQSVAVIFTTLVIGVFALFIHRFVLGPTIRLAELTRDVPGRLKENRRIAWMPPSRISEIQTLLGNFQELTEQLSVMLRETKAQAYYDALTGLPNRRHFNEHLQELLGPETEAAGTTAVLFIDLDRFKQINDTLGHAVGDGLLQEVAARLTGIVGGRAFIARLGGDEFVIVVQDTDSAEVCEMSKKVLRGLVEAFQVGEHELFVAGSIGAALSPQDGSDPETVVKNADAAMYLAKEEGGNAYRFFSGQIAGSISENMRIEFDLRRAIERGELHLHYQPIVDAVDERVVGAEALLRWDHPELGPIPPLQFIGIAESSGLIGTLGEWVLREACGQGARWLAQGLPLFGIGVNLSPTQLTHNNVVDYIGKVLEETGLPPEYLNLEITEEVFSKKTERVIHDLTLLREMGVRVWVDDFGTGYSSLAMLSKLPVVGFKIDRAFIREMGQDLAIVKTILSLAKDKEWIVVAEGIEDEAQKGALLELECRLQQGFHYSRPMPPEELARLLEGQRKKGGTA

Crispr_ID: NC_016935_6

• CRISPR_ID: NC_016935_6
• CRISPR_location: 3005737-3005829
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers
• Cas_protein_info: WYL

Consensus repeat of NC_016935_6

Consensus_repeat	Method
TGCCGCTGTAGGCGGTGCCGTACTTCG	CRISPRCasFinder

spacers of NC_016935_6

>6.1|3005764|39|NC_016935|CRISPRCasFinder
CCTGGAGCACCCCAACGCCGGGCGAGGTGACGGTGCTTC

CRISPR arrays and Neighbor proteins around NC_016935_6

CRISPR arrays

The CRISPR arrays of NC_016935_6

>merge|NC_016935|6|3005737-3005829|CRISPRCasFinder
TGCCGCTGTAGGCGGTGCCGTACTTCGCCTGGAGCACCCCAACGCCGGGCGAGGTGACGGTGCTTCTGCCGCTGCAGGCGGTGCCGTACTTCG

>NC_016935|6|4|3005737-3005829|CRISPRCasFinder
TGCCGCTGTAGGCGGTGCCGTACTTCG	CCTGGAGCACCCCAACGCCGGGCGAGGTGACGGTGCTTC
TGCCGCTGCAGGCGGTGCCGTACTTCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016935.1|WP_013916012.1|2997081_2997318_+|cold-shock-protein	unknown	unknown	gnl|CDD|372943
NC_016935.1|WP_014369762.1|3006508_3007159_-|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_014369759.1|2998903_2999794_-|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|225117
NC_016935.1|WP_014369760.1|3000067_3001399_+|sugar-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|270303
NC_016935.1|WP_013916029.1|3011093_3011468_+|VOC-family-protein	unknown	unknown	gnl|CDD|319909
NC_016935.1|WP_014369765.1|3008804_3009470_+|hypothetical-protein	unknown	unknown	gnl|CDD|377924
NC_016935.1|WP_013916018.1|3002419_3003247_+|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl|CDD|223472
NC_016935.1|WP_013916019.1|3003368_3005351_+|glycoside-hydrolase-family-127-protein	unknown	unknown	gnl|CDD|226063
NC_016935.1|WP_014369768.1|3010750_3011014_+|hypothetical-protein	unknown	unknown	gnl|CDD|226870
NC_016935.1|WP_014369761.1|3001455_3002415_+|sugar-ABC-transporter-permease	unknown	unknown	gnl|CDD|224096
NC_016935.1|WP_014369763.1|3007291_3008236_+|YafY-family-transcriptional-regulator	WYL	COG2378_WYL_CAS-I:CAS-III	gnl|CDD|225253
NC_016935.1|WP_013916010.1|2995514_2996546_+|hypothetical-protein	unknown	unknown	gnl|CDD|237871
NC_016935.1|WP_014369767.1|3010219_3010714_+|methyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|128898
NC_016935.1|WP_014369766.1|3009580_3010024_-|ribonuclease	unknown	unknown	gnl|CDD|238471
NC_016935.1|WP_014369758.1|2997474_2998584_-|GAI-protein	unknown	unknown	gnl|CDD|335361
NC_016935.1|WP_014369764.1|3008249_3008567_+|TfoX/Sxy-family-protein	unknown	unknown	gnl|CDD|377439
NC_016935.1|WP_013916030.1|3011494_3012190_+|LysE-family-transporter	unknown	unknown	gnl|CDD|280058
NC_016935.1|WP_013916021.1|3005538_3005685_+|hypothetical-protein	unknown	unknown	gnl|CDD|226063
NC_016935.1|WP_014369770.1|3012224_3013082_+|phosphotransferase	unknown	unknown	gnl|CDD|366736
NC_016935.1|WP_013916011.1|2996785_2996989_+|cold-shock-protein	unknown	unknown	gnl|CDD|224197

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_016935.1|WP_014369763.1|3007291_3008236_+|YafY-family-transcriptional-regulator	WYL	COG2378_WYL_CAS-I:CAS-III	7.1e-59	194.5	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016935.1|WP_013916012.1|2997081_2997318_+|cold-shock-protein	gnl|CDD|372943	pfam14169, YdjO, Cold-inducible protein YdjO. This family includes the B. subtilis YdjO protein, which is functionally uncharacterized. This is not a homolog of E. coli YdjO. B. subtilis YdjO is cold-inducible. Its expression is induced by the extracytoplasmic function sigma factor sigma-W. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.	1.67292e-29
NC_016935.1|WP_014369759.1|2998903_2999794_-|helix-turn-helix-transcriptional-regulator	gnl|CDD|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	6.14685e-24
NC_016935.1|WP_014369760.1|3000067_3001399_+|sugar-ABC-transporter-substrate-binding-protein	gnl|CDD|270303	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold. This family includes the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.4468e-92
NC_016935.1|WP_013916029.1|3011093_3011468_+|VOC-family-protein	gnl|CDD|319909	cd07245, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	6.356e-28
NC_016935.1|WP_014369765.1|3008804_3009470_+|hypothetical-protein	gnl|CDD|377924	pfam07833, Cu_amine_oxidN1, Copper amine oxidase N-terminal domain. Copper amine oxidases catalyze the oxidative deamination of primary amines to the corresponding aldehydes, while reducing molecular oxygen to hydrogen peroxide. These enzymes are dimers of identical subunits, each comprising four domains. The N-terminal domain, which is absent in some amine oxidases, consists of a five-stranded antiparallel beta sheet twisted around an alpha helix. The D1 domains from the two subunits comprise the 'stalk' of the mushroom-shaped dimer, and interact with each other but do not pack tightly against each other.	1.51965e-07
NC_016935.1|WP_013916018.1|3002419_3003247_+|carbohydrate-ABC-transporter-permease	gnl|CDD|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	1.1677e-87
NC_016935.1|WP_013916019.1|3003368_3005351_+|glycoside-hydrolase-family-127-protein	gnl|CDD|226063	COG3533, COG3533, Uncharacterized protein conserved in bacteria [Function unknown].	0
NC_016935.1|WP_014369768.1|3010750_3011014_+|hypothetical-protein	gnl|CDD|226870	COG4464, CapC, Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane].	0.00261584
NC_016935.1|WP_014369761.1|3001455_3002415_+|sugar-ABC-transporter-permease	gnl|CDD|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	1.39425e-99
NC_016935.1|WP_014369763.1|3007291_3008236_+|YafY-family-transcriptional-regulator	gnl|CDD|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	1.85151e-55
NC_016935.1|WP_013916010.1|2995514_2996546_+|hypothetical-protein	gnl|CDD|237871	PRK14965, PRK14965, DNA polymerase III subunits gamma and tau; Provisional.	0.00902552
NC_016935.1|WP_014369767.1|3010219_3010714_+|methyltransferase-domain-containing-protein	gnl|CDD|128898	smart00650, rADc, Ribosomal RNA adenine dimethylases.	1.62867e-12
NC_016935.1|WP_014369766.1|3009580_3010024_-|ribonuclease	gnl|CDD|238471	cd00933, barnase, Barnase, a member of the family of homologous microbial ribonucleases, catalyses the cleavage of single-stranded RNA via a two-step mechanism thought to be similar to that of pancreatic ribonuclease. The mechanism involves a transesterification to give a 2', 3'-cyclic phosphate intermediate, followed by hydrolysis to yield a 3' nucleotide. The active site residues His and Glu act as general acid-base groups during catalysis, while the Arg and Lys residues are important in binding the reactive phosphate, the latter probably binding the phosphate in the transition state. Barstar, a small 89 residue intracellular protein is a natural inhibitor of Barnase.	2.52824e-46
NC_016935.1|WP_014369758.1|2997474_2998584_-|GAI-protein	gnl|CDD|335361	pfam03514, GRAS, GRAS domain family. Proteins in the GRAS (GAI, RGA, SCR) family are known as major players in gibberellin (GA) signaling, which regulates various aspects of plant growth and development. Mutation of the SCARECROW (SCR) gene results in a radial pattern defect, loss of a ground tissue layer, in the root. The PAT1 protein is involved in phytochrome A signal transduction. A sequence, structure and evolutionary analysis showed that the GRAS family emerged in bacteria and belongs to the Rossmann-fold, AdoMET (SAM)-dependent methyltransferase superfamily. All bacterial, and a subset of plant GRAS proteins, are predicted to be active and function as small-molecule methylases. Several plant GRAS proteins lack one or more AdoMet (SAM)-binding residues while preserving their substrate-binding residues. Although GRAS proteins are implicated to function as transcriptional factors, the above analysis suggests that they instead might either modify or bind small molecules.	9.001e-33
NC_016935.1|WP_014369764.1|3008249_3008567_+|TfoX/Sxy-family-protein	gnl|CDD|377439	pfam04994, TfoX_C, TfoX C-terminal domain. TfoX may play a key role in the development of genetic competence by regulating the expression of late competence-specific genes. This family corresponds to the C-terminal presumed domain of TfoX. The domain is found associated with pfam00383 in Neisseria meningitidis TadA. It is also found as an isolated domain in some proteins suggesting this is an autonomous domain.	9.06493e-23
NC_016935.1|WP_013916030.1|3011494_3012190_+|LysE-family-transporter	gnl|CDD|280058	pfam01810, LysE, LysE type translocator. This family consists of various hypothetical proteins and an l-lysine exporter LysE from Corynebacterium glutamicum which is proposed to be the first of a novel family of translocators. LysE exports l-lysine from the cell into the surrounding medium and is predicted to span the membrane six times. The physiological function of the exporter is to excrete excess l-Lysine as a result of natural flux imbalances or peptide hydrolysis; and also after artificial deregulation of l-Lysine biosynthesis as used by the biotechnology. industry for the production of l-lysine.	9.2881e-17
NC_016935.1|WP_013916021.1|3005538_3005685_+|hypothetical-protein	gnl|CDD|226063	COG3533, COG3533, Uncharacterized protein conserved in bacteria [Function unknown].	8.68235e-05
NC_016935.1|WP_014369770.1|3012224_3013082_+|phosphotransferase	gnl|CDD|366736	pfam01636, APH, Phosphotransferase enzyme family. This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.	3.54407e-05
NC_016935.1|WP_013916011.1|2996785_2996989_+|cold-shock-protein	gnl|CDD|224197	COG1278, CspC, Cold shock proteins [Transcription].	1.01896e-33

Protein sequences

>NC_016935.1|WP_013916021.1|3005538_3005685_+|hypothetical-protein
MLPPVALYFVRSKSDDGRGAVLLPLQAVPYFAWSNRTPGEMTVWIRSS
>NC_016935.1|WP_013916019.1|3003368_3005351_+|glycoside-hydrolase-family-127-protein
MSTIENRLGKTLTPVPLRQVTIQDPFWSARERNVIDTVIPYQWDALNDAIPGAEPSHTIENFRLAAGEAAGDYYGMVFQDSDLGKWLETVGFALSKERSPELEKIADDVIDLLERAQGPDGYLNTYYTVKEPGARWTNLRDNHELYCAGHLMEAAVAYYDATGKRKLLDIMCRYADYIGEVFGREPGQKRGYDGHPEVELALVKLYQASGNRAYLELSRYFVEERGQLPHFFDTEDQERAAAQGDGGAARKRKRGYDYFQAHLPVRDQKTAEGHSVRAVYLYSAMADLAMQYRDAGLREACRELWNDVVERKMYVTGGIGSSAYEERFTVPYDLPNDRAYTETCAAIGLMFWAQRMLQMEQDRRYADVMELALYNGVLSGISLDGKSYFYVNPLEVWPDTANFRDDMRTVKGTRQPWFGCACCPPNIARLIASLGQYIYSVNEEQRELHVHLYAGSRAEVVLGGQPVTLTQTTEYPWNGQAALEIGLAQPAEFTVCVRIPGWCRKAAVTVNGAGTDTGQLEKGYVRITRTWSDGDRIELSFDMPVEIVRAHPNVRAAAGRIALQRGPVVYCLEEADNGPNLQDIVVERDAEFEAEFDAGLLGGVTVLRGMGTRSVVPPEGAGVLYTTQEYDRTAVPLQAVPYFAWSNRTPGEMTVWIRSS
>NC_016935.1|WP_013916018.1|3002419_3003247_+|carbohydrate-ABC-transporter-permease
MKNHAALRAAAHLVLLAGAVTMILPFLWTVSTSLKQLSEVFVFPPKPFGAELQWGNYLRISERFPFDTYFFNSVKITLIVVAAQLVTSSMAGFVFARLRFRGRDLLFGLYLATMMVPAQVTMIPNFIVMRSYNLVDTHWALILPALVSAFGTFLLRQFFVTIPESLEDAAKIDGCTPFGIYWRIFIPLSKPAMATLGVFVFMGTWNDFIAPLVYINSVDLMTLPLGLASMQGMYSTDWPVLMAGTVICILPLIVIFLLAQDFFIKGVTLSGLKGE
>NC_016935.1|WP_014369761.1|3001455_3002415_+|sugar-ABC-transporter-permease
MNAEGRLGKSGAASLHTEKPGGAASAVKRWFHKDGTWAILLLLPNIIGFLAFTLIPVIASFLLSFTSWDMLSPIRWVGFENYAALLKDETFIKVFWNTIYFAGVSVPVGIVCSLFLAVALDQGIAFKKFYRAAYFLPVVSSMVAVAVVWQFIYNPEYGLLNYALSLIGIKGPNWLTSTVWAMPAVILTSVWKNVGFNMLIFLAGLQGIADSYYEAAELDGARWHQKFWYVTVPLLSPTTFFVTVMSFIGSFQVFDTVFLMTQGGPARSTSVIVHYLYENAFKYFNMGYASAMAYVLFFMVFLITLFQLWRQKKWGAYGG
>NC_016935.1|WP_014369760.1|3000067_3001399_+|sugar-ABC-transporter-substrate-binding-protein
MRKLHTVSTVLLCSVFTAACSGGGSPAGGPGSAGDKGGGTAGGVVTLKFMGWEASPLETKSVKKGLEAFMAKHPNIKVEYQPVPNTQYSQKLLTMLAGGAAPDVFFLGSTDYRAFQKRDVLLDLTSMFKADMSLDDFIPSSAQIMDIGGKIYGVSSCTVSPVLYYNKAVFDKAKVPYPPSDPAKAWTWEEFLDAAKKLTVKEGDKVVQYGAFGLENFYMTSAQILSNGGQLFSSDVTKMAINTPEAQEVLQSIYDLRVKHGAAPTAKTLESIGMKANQMLQTGKVAMAVDGSWALQELATMGFPVGVAALPKFKEAVTHGQAHVHAAAAKTKHPKEAWELVKFLSSEEYQIDNIKEGLWMPNRKSLYTEEGVKKWYNASVHPEGFQSLVPYFKEARAFPFPLITQNKVNDIITEETDKLWYSGQSVADTLKNIESRSNVELAK
>NC_016935.1|WP_014369759.1|2998903_2999794_-|helix-turn-helix-transcriptional-regulator
MHYFKTGIERPVEFLSCGLFVSDVPWTHANRIVDSFEIIIGVSKRLYIAQGGTRYEVKPGEVLLLPPGQIHEGYRECEEGISFYWFHFLPAGPYELLDESALSEELAHLNDPDFCRTFSQVCFPLYYTNPRIERVNILFQQLQHIASSNYYTRSAAHYLSTSLLIELSEQMISDYYSSSRMTQGDKSISEIIEWIRIHMRENISVTDVADKFAYNKNYLSRFFKKKTGYNLQEYIHLLKISKAKDLLTRSTRSIKVIAEGVGFQDEKYFMRLFKKYENMTPTEYREAYYRVHMNNH
>NC_016935.1|WP_014369758.1|2997474_2998584_-|GAI-protein
MYSPYAAPSAADHFGQLQTFLARTLAPDAAARTQSELVRFAESLRIDEEASHMLPYLFAKALVKRLDPASHEQMNLYFKQYDVPQITLFNLLASKFPLMNDVTRLANAMLLQAMETGQHVRLLEIGIGTGRQIVGLLHQLKELGKSPASFTIHAIEPNFSCLQEAMDNVGKAAEGLDFPVIFHPIHAEIEQLTDADWQRLIPRQPGLLVNASFALHHIRWIRLGLENKDEVLRQIRLLNPSLVVLCEPDSDHHHPQIEQRMRNCWNHFSALFELIDSVQLPVEHSRGLKLFFGREIEDILSAPETLRCERHEATVNWIARLSEAGFQPCPALQPPEAGSLPDVGITSGAWHVGFGSRALNLISVLCAVS
>NC_016935.1|WP_013916012.1|2997081_2997318_+|cold-shock-protein
MYNKRIPIEDLPHAETKVWTCSDAGCKGWTRDNFTFEQAPTCHLCRSAMVSSIRMLPLIPNSNKEMKTRNQGVLINEG
>NC_016935.1|WP_013916011.1|2996785_2996989_+|cold-shock-protein
METGTVKWFNAEKGFGFIEREGGNDVFVHFSAIQGEGFKSLDEGQRVEFNVVQGNRGPQAENVVKVY
>NC_016935.1|WP_013916010.1|2995514_2996546_+|hypothetical-protein
MSTYDITVEQRDAVYASLSPEQRQFLSEGMLRGRRTAFAMTLARTKGAVIPNEATYEEIEHLLEDWVYTGYTDAGRISAEHSCLCGRPLRYQHRVQHKVTGQVLHFGIEHLKQHLGMDAKTVAAILKGFEVLDAERDELLSKVHSGWTLESQVAVPDGLKLPADIQAHLDLGLPLLDKQLARLKSKIRQLLEPLELQHRRRSAVRDAPAAETAAAPPPAEPEEEWQLAFDLFGGEAAPAAAAAAHPASSAAGAGPDRGANPLTLPERLKPVVIELLSEGVGSVRVMCEVLIQKHRGDGSRSSTGKPVNLYMQVCLYIDDELVRSGRCRLLERSNEDRVYAWAG
>NC_016935.1|WP_014369762.1|3006508_3007159_-|hypothetical-protein
MRISNSTAAAAEFVSCRLKAGVDRVDFLRHVHASQASLKQYPGYVSRELYHDVHQDTWFDLVRWSDLQAAEHAAETFMDHPHAAGLIGCLDPAGLAMHHYNWREELGAVSARNPIDTPSGCVELLQYRLLAGASLPNYEDVLREMSETLRTHAGFIRREVYYIAKTGQWLETIFYRDRASADAMFAEIKDAPCMKACMELLDETTLTMTFAVPVEF
>NC_016935.1|WP_014369763.1|3007291_3008236_+|YafY-family-transcriptional-regulator
MHKAQRLVQLIMLVNERMRFTVQELADECGVSRRTMIRDLMELGELGVPLYSEVGAGGGYRVLREKVLPPISFTEQEAMALFFAAQSLGNYRSLPFGNEVEGALHKFFHYLSSDLKAKIIRMQQRLVFWVPPHELEAPHLGELFEAALEQRVVTLLYESSSLRERNIQPLGIYTMNGLWYCQAYCFSTGEYRVFRVDRVQSCQPAKDQSVRLDAGGEPIDKWIMRPAENADLVLEVELTPEGARRCRTDVWLAKTLRVHDDGSGSIRTPMPDSYVPWAVHFFLGLGVEANVKGPKQVREGIHGKLREMLVQYEE
>NC_016935.1|WP_014369764.1|3008249_3008567_+|TfoX/Sxy-family-protein
MAQERKSEAGGGRIKNMGPKGSQWLESIGIKTREDLERVGSVEAYKRLKESIPGVSILALYAMEAALWDLHWNALPEEIKASLQEQVGHTPPNRAARKGTGTGID
>NC_016935.1|WP_014369765.1|3008804_3009470_+|hypothetical-protein
MKKITAAAVLAVTALGSAAVGVYAASDLKLFVNGKPSPSVVENINGSSYVPLRAVAEMLGAEVKWNGDSRTIHIDAKDAHPEEASVPAAPAEAKTFATSIAVSSGPMRMQISKVILDPAYKKEGAPAPMKAVVLEVKVENTSDERLTWQVGNGKVITNTQEQINGSAASDPVGGEFNGKVIKTGKIVFEVENLDGITSLQYFAEGAYKEGYNPAGANITWK
>NC_016935.1|WP_014369766.1|3009580_3010024_-|ribonuclease
MKTALRFIAMFALMLSLVFGSVGSVIPNGGTSTAEAAVSGPTDFAGIINYIKANGWLPSNFITKSQATQRGWVSSQCNLATVAPGYSIGGDVFYNREGKLPSASGRVWYEADAYYTSGCRGAQRVLFSNDGLYYTTSDHYATFKRWY
>NC_016935.1|WP_014369767.1|3010219_3010714_+|methyltransferase-domain-containing-protein
MERKHTFNEVTREYERYRPRYPKELFEEIAASNSVTPTSPILEIGCGTGQATGGLVESGFDRITCIELGEKLAAAVREKFRHSPNVQVVHAHSKSGRRAPRGTIWRCRPRPFTSNSLRSSVTGWCMICFTRVEASGGCGSTHELTEDEKAAGEAVQAAGYRITA
>NC_016935.1|WP_014369768.1|3010750_3011014_+|hypothetical-protein
MLYGSTESIPYRQAWEVQKVEPELYFGQEIRIVGFIVRDHPPERIYGLKTCVYLMINGGKVIGGHAFPAGEGMAGAYYTLDGKTWRK
>NC_016935.1|WP_013916029.1|3011093_3011468_+|VOC-family-protein
MPFSFEGIDHIQLAAPEGCEEEARGFYAELLGWQEIPKPEPLKKRGGVWFQCGTHQVHIGVQQDFRPALKAHPAFAVRGLEELRARLVQIGIHVIDDEIRAEEGISRIYVRDPFGNRLEFLERH
>NC_016935.1|WP_013916030.1|3011494_3012190_+|LysE-family-transporter
MSILLLSKGILIGLAIAAPVGPIGLLCIRRSLVHGRIYGLVSGLGAATADTIYGFIAGFGLTAVSGFLTAHAFWLQLLGGIFMCYLGWRTLRSKPPEQSAAVQGGSLLKSYSSIFLLTITNPMTILSFAGIFAGLGLTAGSSDWTASLFLVGGVFVGSALWWLLLSTGVGLLRHRLSPSSLAWINRISGWIIMGFGFAAVSLAVHSAVLRLQRDSWLILILSIAWAGSVIL
>NC_016935.1|WP_014369770.1|3012224_3013082_+|phosphotransferase
MAQRADVQDLLQTLRRTGVVDRRTYTQEQLKGTTDGVVYELAVAGETAYILKLDCPEQIRQVERFYEAYADSSLLPRLLQADPAGGSMVYSYVPGTTHIHRGPKVRWMIRLVQELLNQYQAYPGIGGWGRLEAPRESWRAFQERSAEDASHILAGVLPAEAHARIRGLIGRISDAGEPYLLHGDTGIHNFVFHHRELSGVIDPSPMTGPVLYDFTYAFCSSPDDLNLDTLLAAYDMLDPKPVDRTRLMEETFFQLYCRIAICVRVHPQDLEGYLQVWPYWRDLIS

Crispr_ID: NC_016935_7

• CRISPR_ID: NC_016935_7
• CRISPR_location: 3237102-3237316
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 4 spacers

Consensus repeat of NC_016935_7

Consensus_repeat	Method
AATCTGTTGGCTAGTACAACCT	CRT

spacers of NC_016935_7

>7.1|3237124|23|NC_016935|CRT
GTCCCGTTTCAATCCTTCCCTTT
>7.2|3237169|24|NC_016935|CRT
CTTTCGGGGAGGACGCTCGCTGCG
>7.3|3237215|25|NC_016935|CRT
TTATTGGATGTATTCGCTCCGTGCG
>7.4|3237262|33|NC_016935|CRT
GGTTGTACCTGGATGCCGCTGGAAAAAAGCCTG

CRISPR arrays and Neighbor proteins around NC_016935_7

CRISPR arrays

The CRISPR arrays of NC_016935_7

>merge|NC_016935|7|3237102-3237316|CRT
CATCTGTTGGCTAGTACAACCTGTCCCGTTTCAATCCTTCCCTTTAATCTGTTGGCTAGTACAACCGCTTTCGGGGAGGACGCTCGCTGCGAATCTGTTGGCTAGTACAACCTTTATTGGATGTATTCGCTCCGTGCGAATCTGTCCGCCAGTACAACCTGGTTGTACCTGGATGCCGCTGGAAAAAAGCCTGAATCTGTTGGCTAGTACAACCT

>NC_016935|7|3|3237102-3237316|CRT
CATCTGTTGGCTAGTACAACCT	GTCCCGTTTCAATCCTTCCCTTT
AATCTGTTGGCTAGTACAACCG	CTTTCGGGGAGGACGCTCGCTGCG
AATCTGTTGGCTAGTACAACCT	TTATTGGATGTATTCGCTCCGTGCG
AATCTGTCCGCCAGTACAACCT	GGTTGTACCTGGATGCCGCTGGAAAAAAGCCTG
AATCTGTTGGCTAGTACAACCT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016935.1|WP_013916248.1|3229524_3229878_+|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_014369924.1|3227305_3229360_+|HAMP-domain-containing-protein	unknown	unknown	gnl|CDD|223910
NC_016935.1|WP_014369929.1|3241370_3242813_+|glycoside-hydrolase-family-1-protein	unknown	unknown	gnl|CDD|225343
NC_016935.1|WP_013916270.1|3249517_3249838_-|YnfA-family-protein	unknown	unknown	gnl|CDD|235016
NC_016935.1|WP_014369932.1|3244828_3245836_-|DUF3231-family-protein	unknown	unknown	gnl|CDD|371599
NC_016935.1|WP_014369925.1|3231526_3232192_-|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|378968
NC_016935.1|WP_014369931.1|3244169_3244700_+|DoxX-family-protein	unknown	unknown	gnl|CDD|225168
NC_016935.1|WP_013916256.1|3234181_3234751_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228
NC_016935.1|WP_013916251.1|3231204_3231543_-|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_014369933.1|3245970_3246129_+|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_014369936.1|3250019_3250367_+|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_014369935.1|3248392_3249397_+|C40-family-peptidase	unknown	unknown	gnl|CDD|366353
NC_016935.1|WP_041617829.1|3230032_3230248_-|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_014369927.1|3237895_3239299_+|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_148279743.1|3224690_3227180_+|glycoside-hydrolase-family-2-protein	unknown	unknown	gnl|CDD|225789
NC_016935.1|WP_014369934.1|3246502_3248152_+|alginate-lyase-family-protein	unknown	unknown	gnl|CDD|377511
NC_016935.1|WP_014369926.1|3233102_3233981_-|NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|224995
NC_016935.1|WP_014369930.1|3242899_3243877_+|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl|CDD|380509
NC_016935.1|WP_013916257.1|3234975_3236319_+|replication-initiation-protein	unknown	unknown	gnl|CDD|376444
NC_016935.1|WP_013916250.1|3230549_3231152_-|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP	unknown	unknown	gnl|CDD|178955

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016935.1|WP_014369924.1|3227305_3229360_+|HAMP-domain-containing-protein	gnl|CDD|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	2.46053e-53
NC_016935.1|WP_013916270.1|3249517_3249838_-|YnfA-family-protein	gnl|CDD|235016	PRK02237, PRK02237, YnfA family protein.	1.60925e-42
NC_016935.1|WP_014369932.1|3244828_3245836_-|DUF3231-family-protein	gnl|CDD|371599	pfam11553, DUF3231, Protein of unknown function (DUF3231). This bacterial family of proteins has no known function.	8.46896e-54
NC_016935.1|WP_014369925.1|3231526_3232192_-|helix-turn-helix-transcriptional-regulator	gnl|CDD|378968	pfam12840, HTH_20, Helix-turn-helix domain. This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.	1.89763e-08
NC_016935.1|WP_014369931.1|3244169_3244700_+|DoxX-family-protein	gnl|CDD|225168	COG2259, COG2259, Predicted membrane protein [Function unknown].	9.8125e-07
NC_016935.1|WP_013916256.1|3234181_3234751_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.76819e-16
NC_016935.1|WP_014369929.1|3241370_3242813_+|glycoside-hydrolase-family-1-protein	gnl|CDD|225343	COG2723, BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase [Carbohydrate transport and metabolism].	0
NC_016935.1|WP_014369935.1|3248392_3249397_+|C40-family-peptidase	gnl|CDD|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	1.54156e-23
NC_016935.1|WP_148279743.1|3224690_3227180_+|glycoside-hydrolase-family-2-protein	gnl|CDD|225789	COG3250, LacZ, Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism].	1.49982e-96
NC_016935.1|WP_014369934.1|3246502_3248152_+|alginate-lyase-family-protein	gnl|CDD|377511	pfam05426, Alginate_lyase, Alginate lyase. This family contains several bacterial alginate lyase proteins. Alginate is a family of 1-4-linked copolymers of beta -D-mannuronic acid (M) and alpha -L-guluronic acid (G). It is produced by brown algae and by some bacteria belonging to the genera Azotobacter and Pseudomonas. Alginate lyases catalyze the depolymerization of alginates by beta -elimination, generating a molecule containing 4-deoxy-L-erythro-hex-4-enepyranosyluronate at the nonreducing end. This family adopts an all alpha fold.	1.93671e-36
NC_016935.1|WP_014369926.1|3233102_3233981_-|NAD(P)-dependent-oxidoreductase	gnl|CDD|224995	COG2084, MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism].	1.19294e-29
NC_016935.1|WP_014369930.1|3242899_3243877_+|LacI-family-DNA-binding-transcriptional-regulator	gnl|CDD|380509	cd06286, PBP1_CcpB-like, ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species. This group includes the ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species. Catabolite control protein B (CcpB) is 30% identical in sequence to CcpA which functions as the major transcriptional regulator of carbon catabolite repression/regulation (CCR), a process in which enzymes necessary for the metabolism of alternative sugars are inhibited in the presence of glucose. Like CcpA, the DNA-binding protein CcpB exerts its catabolite-repressing effect by a mechanism dependent on the presence of HPr(Ser-P), the small phosphocarrier proteins of the phosphoenolpyruvate-sugar phosphotransferase system, but with a less significant degree.	2.21707e-117
NC_016935.1|WP_013916257.1|3234975_3236319_+|replication-initiation-protein	gnl|CDD|376444	pfam01051, Rep_3, Initiator Replication protein. This protein is an initiator of plasmid replication. RepB possesses nicking-closing (topoisomerase I) like activity. It is also able to perform a strand transfer reaction on ssDNA that contains its target. This family also includes RepA which is an E.coli protein involved in plasmid replication. The RepA protein binds to DNA repeats that flank the repA gene.	4.2356e-05
NC_016935.1|WP_013916250.1|3230549_3231152_-|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP	gnl|CDD|178955	PRK00277, clpP, ATP-dependent Clp protease proteolytic subunit; Reviewed.	3.74909e-140

Protein sequences

>NC_016935.1|WP_013916257.1|3234975_3236319_+|replication-initiation-protein
MPRGKKTQDAGKAGTQQKSLAGKLIRELEMKGEETEAASSIDEQDTKPRSNTKPKVKSSIIRLADKAEAMAEKLIRQIEQSTNPDDVTSVEDLLKESASKLDSTKSYLTKDITEASVYLLQKLSQIVSETSSVVDNLSLTKNQYARQIIKLAKEMRERKKTQPMELNLMASNPFFTGIPNSYKEKVKETGLAEVVKNGTKTLEYQNSEGLYLSEFDKRVFTALTSIWVDQNCKQIFKFTEFELLRRLEMNPKGGMQHKRVRDSLRALTTTQIVIKEFYEKKNANRIVTSKFHLVASETTIEEYSKDDGKLQSREYQFQFADQIRQSFQDGYTTLISLGILDTLNTKTSRELYQLLCTIRDMAPQEQFKYTVEAGAFDVSLTEISEYMHLANNEYDNRRNILKACEELKEVYVLQDYVKLGTGRSCSAIRFYPGTLLKKEEVKVLTQG
>NC_016935.1|WP_013916256.1|3234181_3234751_-|TetR/AcrR-family-transcriptional-regulator
MSTAPTSSRQRLLDVASDLFYREGIRAISMDTIVERSGVSKATLYRHFPTKDELISAYLKAHDHHIWEHFDEAVAKHEGSPKDQLLALIDAIAELFQPEYYRGCPFLNAFAEFSDPHHPAHRLAMEYNHALRSRLSDLSRKAGVTDESWPDQLLLVINGAYSSVPVLGLTGSAAQLKKLTAQMIHQYVH
>NC_016935.1|WP_014369926.1|3233102_3233981_-|NAD(P)-dependent-oxidoreductase
MSEVSIIGLGPMGTALAQTFLNNDKRITIWNRTASKAESLVRQGAVLASSAASAINASPITIICVANYGSSASLLDTQEAASALAGRTLIQLSTGTPQEARNSEFWARERGAYYLDGAIQAWPSHIGAPETVILFSGSSTAFQTSEPLLRILAGNSIYLGEPVGSASAQALAVISYLLGTWLGFAHGAHILESEHLPVDSFGSMIAAIAPLLGEEAKHQGKVIQTGKFGNPESSLQTSADSVERLLQQATEAGINSDFPRFALPLFAKAAAAGYGDEEVSAIIKILRGGPAS
>NC_016935.1|WP_014369925.1|3231526_3232192_-|helix-turn-helix-transcriptional-regulator
MTPHEPILESVLIDSPEQAMVLLNPLRAEIAARLSEPGSAAEVARAIGEAPQRINYHLKALEKAGLVRRVGSRQVRNLVEVLYQSIARTFVLSERLGMKPETVRKLKDQGSLAHLIGTADRIKQDALLLMEHSDEGEEVPSATLQFQVELATPERRQAFVEEYARLVQELTAKYGGDAAEGAYQVVVAVYPEASGRAAAPEGAQEKPAPKKRRKRIDGTQA
>NC_016935.1|WP_013916251.1|3231204_3231543_-|hypothetical-protein
MEHKPKKEFAAGTEEQRPGNAPQPAVVWESKSTAETAPPDRGQVSDLSAYRERKEAAAPDREATVTRWALPGRQKGDPAQWLIMVSSGFGAAPAVIHSGRGGAGDVKACLAA
>NC_016935.1|WP_013916250.1|3230549_3231152_-|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP
MNYIPMVVEQTGRGERSYDIYSRLLKDRIIFLGSAIDDTVANSIIAQLLLLSAEDPDKDIHLYINSPGGSTTAGLGILDTMQYIKPDVSTICVGMAASMAAVLLVSGAPGKRFALPHAEVMIHQPHGGSQGQASDIHIHAQRIVQTRELLNRIIAERSGQPFEKIERDTDRDYFMTAPAALEYGIIDKVLHSVQGTGAAS
>NC_016935.1|WP_041617829.1|3230032_3230248_-|hypothetical-protein
MESMCMNMMMTMCMEDMMGKMNCMKTMMNTMNEMNMTDCMDMNSMMMKMQQCDEMMTSMMETMRKMEQVSK
>NC_016935.1|WP_013916248.1|3229524_3229878_+|hypothetical-protein
MSLTARKDWEQAWVDDYLDLLNMAKRLQDTQWEQELLQTLQEYKRHTAAEIHYRFTQELWRRFDEINRRMLELYEKLKANRDQQENRLLQEQVWDLKLERIEVMRRIHSGENGIPAQ
>NC_016935.1|WP_014369924.1|3227305_3229360_+|HAMP-domain-containing-protein
MKHTAKGIISRVRNASLRVKLPILISLLVIAALLATSITTYIYSSNLVLRKSKDEINAMADRLGEGLWTSLQLQEQSTFLVSNHGTYRDLLKLREAGTLADADFFSARNPYFEKSNEILKTSLAGAKDTSSYLVVDPKGIIVSATTIENIGQSRADREYFTEALQGKSFVSDAIESKSTGKILLAFSVPIKDSDGRILGVFVTTVDSQFFVGKLGNVTINGEGGIEILSRGGTFLYSSKDPSIIGTKLQAEEFLKDRAAGEIKVISMDLDNQYLRINKIPGADLTITVLDTYADIERPINDMFKVIALITLVIILASIGFGLLLSRYMSKPLVEMAGLFKQLAQGDLTIKAEDKYDGEFKVLADSFNSMVSQNKDLITRMNQSIEVLHTSTNELEASSKQTASSINETSVTSVEIAKAMESQSHDTEHIVDKFYGFGEKFASMSAKARSVGERADEIIGVFHKSSEVVNELSHINQQNEEQVQKISAITAKLQESSDHISSITGAISDIANQTNLLALNASIEAARAGEHGRGFSVVASEIRRLAEQSSQQSNEIYAIIQQNLAFVAENNQSVSEIRTIALQQDEFVGQTQLAFQAILEKITEIADQIKGMTEEVARMERDKDEVLESAQSLSASGEEVSASVEEVTATMVEQSATVHQLADMVQTIDRLTRELAEAASRFKVE
>NC_016935.1|WP_148279743.1|3224690_3227180_+|glycoside-hydrolase-family-2-protein
MGELGMKKIRDFSGTWQMRRRNEDTWMEAQVPGSVFADLMRSGRMGDPFFRDGVEQAKELARHEYEYKRSFTADEELLASDKILLVCDGLDTLAQIRLNGQPLAETDNMHRSYTFDVTAMLCPGLNTLHISFGSALLHAEQRHAEHPIWCTTVGATGGFNQIRKASYMFGWDWAPVLPDMGIWRNIRLEGYSAGRLSDVFVTQQHEPEGEVGLAVRIRSSLWTAEGVFAEVTLNGPDGEVLHRTAHACSGEDLTVDVLVAEPELWWPNGYGEQPLYELAVVLLGRAGQTLDERKLRIGLRTITWRREPDAWGESFECVVNGVPVFAKGANYVPQDSLLSRCTPERTERLIRDCTEAHFNMLRVWGGAFFPGDEFYDLCDRYGLLVWQDLLFACAAYEMTEAFTENIARETADNVIRIRHHACLALWCGNNEMEWAWVEWSLPKTGKLRSDYIKQFEMVLPAVVKTHDPQTFYWLASPSSGGGFDHPNDPSRGDVHYWDVWHGTKPFTDYRKSLFRFCSEFGFQSYPDLKTVESFTLPEDRNVFSYVMERHQTHPEANGKIMNYLAQLFKFPKDLDSLIYVSQLVQAEAIRYGVEYWRQNRGICMGSLYWQLNDCWPAASWSSIDYYGRWKALHYAAKRFYSPLCVSASERDLKVEIHVTNDMPEPAEGLLEWQLRDHRSRVLQEGGVWTTAAELASCCPLQLDFRGELTDSERRRCYLEYRWRNAEGEVLSRGTVLFVPSKHFELLPPQVDAEVEETADSFLVRVQSAAFARYVELTLRQTDGVASDNYIDLSAGEPREIFFPKDRLSVPLSLEAFRGQLRLRSLYDIE
>NC_016935.1|WP_014369927.1|3237895_3239299_+|hypothetical-protein
MIYKDTYHLMMNSLSSTEIDACLAMLLHLDWENRLRTEPEHLARQIGTTSKYMGDILRKFLRDKKVLSKDRKDDTYAFRYGQSSLQYDERTTKYGKKFSLYYTPQFRSLSLNAKRLLIMALFRISETRDTEFHIPRLRLIRRSGQEGRLPLTGTQLLDVLQELRDAQIPGLSSAEIVQFQGEANVVIRFSDDIQQAYLENHTEMNLVKRELFKLGLHRLVPSDELCHALLSVGYHLFKSMLEADFAMNRREGEAEERRQGILRTARHMYNTALARLAASFPAKRMELTNKDKLAAYFSAIVHEVMTQEMASCSYQVLQQESLLDYYMDKTKQEGITYGGPEVKALVLHIDGMKRMAAVLETVCQQWLLSRVATLSKDLSEAARSTQDQERILDRRGWTSIEEGKAQLRKLLKHEEELLAAMRAHVGSGVRVPARVLEEAMERYFVEIQTRAADLAAKNSRMNTDKTA
>NC_016935.1|WP_014369929.1|3241370_3242813_+|glycoside-hydrolase-family-1-protein
MIHTQVRPFPQDFLWGSASAAYQIEGAWNEDGKGPSVWDVFTKIEGTTYKGSNGDVAMDHYHRYREDIALMAEMGLKAYRFSVSWPRIYPSGHGEVNEAGLQFYDNLIDELLAHGIEPVLTLYHWDVPQALMDEYGAWESRRIIEDFDNYCITLFKRYGDRVKYWVSLNEQNYNTNHGFITAMHPPGVKDRKRFYQANHHAFLANAKVIDSFRHYVPHGKIGPSFAYSPAYPASSKPEDLLAFENAEEFTNYWWLDVYCLGQYPQIPLRYLEEQGLAPVFEEGDLELLRRGRPDFVGVNYYQTITYETNPLDGVAEGRMNTTGQKGSNQSTGMPGLFKTAANPNLETSNWDWAIDPIGLRIGMRRITSRYGLPVFITENGLGEFDKLEADDTVHDDYRIAYLRSHLLQCQQAMSEGVELIGYCSWSFTDVLSWLNGYQKRYGFVYIDRDETDARSLRRIKKLSFHWYREVIRTGGEHLLK
>NC_016935.1|WP_014369930.1|3242899_3243877_+|LacI-family-DNA-binding-transcriptional-regulator
MANIREIAKAAGVSVATVSRVLNSHPYVSAEKRRRVEEAMRRAGYSPNSNAVHLSTGRTGMVGVILPFSHHPYFHALLGGLMEEALKHQYTALLCQTNYEAGEERRYLQMLRTKQVDGLILCSHELPWAEIAAYAADGLLVACEPVRQEGISCVYTHHYEAFLTGMRYLIRRGHRNIGFCIGRRDSESSRQRYAAYADALQEIGRPVQPEWIFEGCTDLRDGMRVMDRIAAMESRPSALLVTGDEAAAGVLARSRQLGIAIPGELAVVGFDNQPISEALQLTTIDQHLQEIGRQAFGAFYHGIVQPGAAPRRMEVPFALVERTSV
>NC_016935.1|WP_014369931.1|3244169_3244700_+|DoxX-family-protein
MLTRFLRDNVYAAGLLLILRLYVGYQWFTAGFHKLTGGFDAAGFLKGAIAKPVLDKATGELVYPTFTAFLQNFALPNVKVINFLIPAGETLVGLGLILGALTTAAAFFGLLMNFMFLFAGTVSTNPWLVLLGVIVLMAGTNAGRFGVDRYLMPLLRKLRRQGGDEAGRRKGIPAKA
>NC_016935.1|WP_014369932.1|3244828_3245836_-|DUF3231-family-protein
METAHNIPLTAPEISNLWSGYQGDTLSRCVLTHFAAHVEDTEVRELIAYALELCDKHITRLLGYFETEKIPVPQGFGDEDVDPKAPRLFSDIFYLGYLLNMGKQGMALYAYSVPVSSRQDIREYLSECLASSSALYNRTLDLMLAKGVYVRPPRIPVPEAREYVHKESYFYALFEDKRPVNGPEIAHLYANIVTNLMGKALTLGFAQTAVSKDIRAYLLRGHEISGKHVEVFSSLLRDDGLPAPNYWDDGVTASTTPPYSDRLMMYHIGALSATGAVNYGVAAPNSTRRDITSVYVRLIGEIAKYGEDGAELMLKHQWMEKIPGAVERGSLVHQS
>NC_016935.1|WP_014369933.1|3245970_3246129_+|hypothetical-protein
MLNQLILWSLLSIPWFSLLFMDTTKLRRFFPVALLVTVINTLFYQAASSKWS
>NC_016935.1|WP_014369934.1|3246502_3248152_+|alginate-lyase-family-protein
MRNQGRRKLPVLAAAGLAAGLVFSSAAAAYPHPGGVHSEAQLASAKRNIAGGLQPWADAMKELIPRADFYLSEPPSASADFHVPGYYEDPAGHTGASEVLHTDVRAAYASALAYRLTGRTAYAEKAKAILNDWAFRNTAVSGTDGPLVMTYSGVGFIHAAELLRDYSGWSEADKTAFSNWLTNVYLARAANPIKTRSNNWGDWGIYGAMAAYYYKDDPVLLNAEITRLKNKIDSSIAADGSMPHEAGRGASGLWYTYFALAPMTAAAQIAKEAAGIDLFQWTSPGGRTIKQALDYLLFYMNRPDQWPYGANPRMPVSDEEWGYNLFEAMSDYYDEPAYKSFASVKGPIMYLASHFAWNFPSVTKGGLRLVDEKFDALTSTAAPRGWTVSKAANTSAVVWNTPTAADKSLKIWDTSTSGTASAVKVFPDQYGIIEAEWKFMYMALFPNARFGLKHAAVYAAELLTTASGLIYRSGTGSDIVLQTLSPEAWYTVKLIANPASDKTDVYVNGQLKASGVPFRSTVSALDRIEFAGGSGETGTFYIDQVKIMN
>NC_016935.1|WP_014369935.1|3248392_3249397_+|C40-family-peptidase
MKRIITAASAALIAGVFALPQGQAQAATTSTIVSDVSFRKAPDTDAARIRYLQEDEKVTVVSKVNDYWYKVTDKNGVTGYVSSSSKYISAPRTTSTGTAAASNTGKIVSGVSFRKAADTDAARIRYLQEGETVTILDKVNSYWYKVKDKNGVTGYVSTSSKYISASYKETASAAPAGTTSGGTSSSTTSTQKVEKVIAAGMKYLGTPYEYGSDRSTVATFDCSDFVRQAFKDALGVTLPSNSRTQADYVREHSSRIVTDIDNLKRGDLVFFMSYRGSSLSAYSGMDKSAQRITHVGIYLGDGKMLNTWGTGGVKVDTITGRHWEGRFIFGGSAL
>NC_016935.1|WP_013916270.1|3249517_3249838_-|YnfA-family-protein
MAVVLFLLAGLAEIGGGYLVWLWLREGRSLWLGLTGCLVLVAYGIIPTLQSFPSFGRVYAAYGGVFIVLAVLWGWLIDRKTPDLYDWIGAVVCTAGVAIMLWAPRG
>NC_016935.1|WP_014369936.1|3250019_3250367_+|hypothetical-protein
MNLMYGFGLLAAGLSIINAIFSYQAKAIDPGFGPMLWFQLRMLPLMFFSNVMIGYGVKYLYRAFQSLTFALTVSKGLEILVCVVMGYLFLKEVPTWRTYAGLGVVVCGFVLTRWK

Crispr_ID: NC_016935_8

• CRISPR_ID: NC_016935_8
• CRISPR_location: 3256423-3256508
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_016935_8

Consensus_repeat	Method
TACATCTCGCTGGCAGAAAAAGATAAAAG	CRISPRCasFinder

spacers of NC_016935_8

>8.1|3256452|28|NC_016935|CRISPRCasFinder
ACAAAAGATAAAAAAGAACCATCACACT

CRISPR arrays and Neighbor proteins around NC_016935_8

CRISPR arrays

The CRISPR arrays of NC_016935_8

>merge|NC_016935|8|3256423-3256508|CRISPRCasFinder
TACATCTCGCTGGCAGAAAAAGATAAAAGACAAAAGATAAAAAAGAACCATCACACTTACATCTTGCTGGCAGAAAAAGATAAAAG

>NC_016935|8|5|3256423-3256508|CRISPRCasFinder
TACATCTCGCTGGCAGAAAAAGATAAAAG	ACAAAAGATAAAAAAGAACCATCACACT
TACATCTTGCTGGCAGAAAAAGATAAAAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016935.1|WP_014369945.1|3263486_3265247_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224055
NC_016935.1|WP_014369939.1|3253852_3256276_+|EAL-domain-containing-protein	unknown	unknown	gnl|CDD|238923
NC_016935.1|WP_014369936.1|3250019_3250367_+|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_014650693.1|3258899_3259262_+|response-regulator	unknown	unknown	gnl|CDD|381097
NC_016935.1|WP_013916270.1|3249517_3249838_-|YnfA-family-protein	unknown	unknown	gnl|CDD|235016
NC_016935.1|WP_014369932.1|3244828_3245836_-|DUF3231-family-protein	unknown	unknown	gnl|CDD|371599
NC_016935.1|WP_014369942.1|3259519_3260215_+|metal-dependent-hydrolase	unknown	unknown	gnl|CDD|234811
NC_016935.1|WP_041619445.1|3267408_3268662_-|histidine--tRNA-ligase	unknown	unknown	gnl|CDD|273080
NC_016935.1|WP_014369938.1|3251960_3253664_+|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl|CDD|214599
NC_016935.1|WP_013916272.1|3250441_3250657_+|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_014369933.1|3245970_3246129_+|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_014369937.1|3250870_3251923_+|substrate-binding-domain-containing-protein	unknown	unknown	gnl|CDD|380646
NC_016935.1|WP_014369948.1|3269200_3270727_-|LTA-synthase-family-protein	unknown	unknown	gnl|CDD|293739
NC_016935.1|WP_014369940.1|3256523_3257543_-|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl|CDD|224525
NC_016935.1|WP_014369934.1|3246502_3248152_+|alginate-lyase-family-protein	unknown	unknown	gnl|CDD|377511
NC_016935.1|WP_014369949.1|3270940_3272143_+|DUF2087-domain-containing-protein	unknown	unknown	gnl|CDD|198398
NC_016935.1|WP_014369946.1|3265243_3267004_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224055
NC_016935.1|WP_014369935.1|3248392_3249397_+|C40-family-peptidase	unknown	unknown	gnl|CDD|366353
NC_016935.1|WP_014369944.1|3260921_3263273_-|EAL-domain-containing-protein	unknown	unknown	gnl|CDD|236645
NC_016935.1|WP_014369943.1|3260252_3260711_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|225064

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016935.1|WP_014369945.1|3263486_3265247_+|ABC-transporter-ATP-binding-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	3.91424e-133
NC_016935.1|WP_014369939.1|3253852_3256276_+|EAL-domain-containing-protein	gnl|CDD|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	1.33718e-112
NC_016935.1|WP_014369934.1|3246502_3248152_+|alginate-lyase-family-protein	gnl|CDD|377511	pfam05426, Alginate_lyase, Alginate lyase. This family contains several bacterial alginate lyase proteins. Alginate is a family of 1-4-linked copolymers of beta -D-mannuronic acid (M) and alpha -L-guluronic acid (G). It is produced by brown algae and by some bacteria belonging to the genera Azotobacter and Pseudomonas. Alginate lyases catalyze the depolymerization of alginates by beta -elimination, generating a molecule containing 4-deoxy-L-erythro-hex-4-enepyranosyluronate at the nonreducing end. This family adopts an all alpha fold.	1.93671e-36
NC_016935.1|WP_014650693.1|3258899_3259262_+|response-regulator	gnl|CDD|381097	cd17542, REC_CheY, phosphoacceptor receiver (REC) domain of chemotaxis protein CheY. The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	1.62348e-52
NC_016935.1|WP_013916270.1|3249517_3249838_-|YnfA-family-protein	gnl|CDD|235016	PRK02237, PRK02237, YnfA family protein.	1.60925e-42
NC_016935.1|WP_014369932.1|3244828_3245836_-|DUF3231-family-protein	gnl|CDD|371599	pfam11553, DUF3231, Protein of unknown function (DUF3231). This bacterial family of proteins has no known function.	8.46896e-54
NC_016935.1|WP_014369938.1|3251960_3253664_+|methyl-accepting-chemotaxis-protein	gnl|CDD|214599	smart00283, MA, Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.	6.97855e-52
NC_016935.1|WP_041619445.1|3267408_3268662_-|histidine--tRNA-ligase	gnl|CDD|273080	TIGR00442, hisS, histidyl-tRNA synthetase. This model finds a histidyl-tRNA synthetase in every completed genome. Apparent second copies from Bacillus subtilis, Synechocystis sp., and Aquifex aeolicus are slightly shorter, more closely related to each other than to other hisS proteins, and actually serve as regulatory subunits for an enzyme of histidine biosynthesis. They were excluded from the seed alignment and score much lower than do single copy histidyl-tRNA synthetases of other genomes not included in the seed alignment. These putative second copies of HisS score below the trusted cutoff. The regulatory protein kinase GCN2 of Saccharomyces cerevisiae (YDR283c), and related proteins from other species designated eIF-2 alpha kinase, have a domain closely related to histidyl-tRNA synthetase that may serve to detect and respond to uncharged tRNA(his), an indicator of amino acid starvation; these regulatory proteins are not orthologous and so score below the noise cutoff. [Protein synthesis, tRNA aminoacylation].	1.23674e-176
NC_016935.1|WP_014369942.1|3259519_3260215_+|metal-dependent-hydrolase	gnl|CDD|234811	PRK00685, PRK00685, metal-dependent hydrolase; Provisional.	2.4717e-114
NC_016935.1|WP_014369937.1|3250870_3251923_+|substrate-binding-domain-containing-protein	gnl|CDD|380646	cd19991, PBP1_ABC_xylose_binding, D-xylose binding periplasmic protein. Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein (PBP1) superfamily, which consists of two alpha/beta globular domains connected by a three-stranded hinge. This Venus flytrap-like domain undergoes a transition from an open to a closed conformational state upon ligand binding. Moreover, the periplasmic xylose-binding protein is homologous to the ligand-binding domain of eukaryotic receptors such as glutamate receptor (GluR) and DNA-binding transcriptional repressors such as LacI and GalR.	6.70183e-122
NC_016935.1|WP_014369949.1|3270940_3272143_+|DUF2087-domain-containing-protein	gnl|CDD|198398	cd10451, GIY-YIG_LuxR_like, GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria. The family includes some bacterial LuxR and ArsR family transcriptional regulators. The a C-terminal conserved domain shows sequence similarity to the N-terminal catalytic GIY-YIG domains of intron-encoded homing endonucleases. Besides, they have an N-terminally fused transcriptional regulators module, comprising the winged helix-turn-helix (wHTH) domain and uncharacterized domain DUF2087. At this point, they are distinct from GIY-YIG homing endonucleases, which typically contain a variety of C-terminally fused nuclease-associated modular DNA-binding domains (NUMODs). Moreover, some key residues relevant to catalysis in GIY-YIG endonucleases are mutanted or absent in this family, which suggests that members in this family might lose the catalytic function that GIY-YIG endonucleases possess. This family also includes many uncharacterized hypothetical proteins that consist of a standalone GIY-YIG like domain.	3.01099e-35
NC_016935.1|WP_014369948.1|3269200_3270727_-|LTA-synthase-family-protein	gnl|CDD|293739	cd16015, LTA_synthase, Lipoteichoic acid synthase like. Lipoteichoic acid (LTA) is an important cell wall polymer found in Gram-positive bacteria. It may contain long chains of ribitol or glycerol phosphate. LTA synthase catalyzes the reaction to extend the polymer by the repeated addition of glycerolphosphate (GroP) subunits to the end of the growing chain.	5.1599e-66
NC_016935.1|WP_014369940.1|3256523_3257543_-|LacI-family-DNA-binding-transcriptional-regulator	gnl|CDD|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.06126e-93
NC_016935.1|WP_014369943.1|3260252_3260711_+|GNAT-family-N-acetyltransferase	gnl|CDD|225064	COG2153, ElaA, Predicted acyltransferase [General function prediction only].	9.38018e-17
NC_016935.1|WP_014369946.1|3265243_3267004_+|ABC-transporter-ATP-binding-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	3.20325e-99
NC_016935.1|WP_014369935.1|3248392_3249397_+|C40-family-peptidase	gnl|CDD|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	1.54156e-23
NC_016935.1|WP_014369944.1|3260921_3263273_-|EAL-domain-containing-protein	gnl|CDD|236645	PRK10060, PRK10060, cyclic di-GMP phosphodiesterase.	3.51827e-116

Protein sequences

>NC_016935.1|WP_014369939.1|3253852_3256276_+|EAL-domain-containing-protein
MHPTEQGIEGSYDWVLVLLSYLIAVIASYTALDMGGRVSSSQGRARSAWLLCGAAAMGIGIWSMHFVAMLAFRLPVHTSYDLGLVLLSMLFAVLGSYAALFMIARPQLTVGRLSTGSLLMGSAVAAMHYTGMASMRMEAVITYAPVPFAASLVIAVGASAAAMWLTFYFRGEGGIRAFYRKLISGLVMGGAIVGMHYTGMAAAHFTESGASAHGMVMGGAYLGYAVGLATLIVLSTALVTAFFDRRIASATAKLSESEQQFKSLFEHNLDGVVAFDLQGRVTAVNPAVTRITGYTQEESLEIHLTELRSASNPGDLQRYFHQAVSENSSVKFESVVRHKRGHEVAVIVTTVPIVVDEEVTGVYGIIQDITRNREAEQLIKHMAYHDDLTGLPNRRYLLARIRELGTNPGAMLLLLDIDRFKMLNDSIGARLGDELLRQLAGRLRSEAGEAGTAARIGSDEFAVLFPWSGGQGEPEKLAGRIMEALSRQYDLDAHKLHLSVSAGYDLSAGCDNHELLLEHAGTALFQSKKEGLGRALAYTAEMDAATREKLELEKGLREALEREQFEVHYQPQLDMFGNLIGSEALVRWRHPERGYIPPGVFIPVAEENGLINPIGSWVLRTACRQNRAWQLEGRAPVPVSVNLSIKQFEQPNLVEIVQSALADSGLTPQYLELEITESMAMNAAATEGTLYLLKALGVKVSMDDFGTGYSSLSYLNRFPIDKLKIDQSFVRDLFKEESGASIVATIVAMAHHLKLSVIAEGVETREQLEFLREQKCDQVQGYYYSPPLKPEAFSRFWDELENGTKKG
>NC_016935.1|WP_014369938.1|3251960_3253664_+|methyl-accepting-chemotaxis-protein
MRFSIRAKLISGFLLCTFLLVIANAVGLFRISMLGDAVTRITSVHLQQVILINDMGQSMKNMENSMLQMLSTAKYSEIQELKKAIADEQEKMKELRAKYESMPQGHGTEGLYYQFTNDWEAFEGTIPQLIQEVETPGSSLAETKTINLMKYLSRKANASAEELVQANRAEAERQSTAAGRIITSSKTIMITLGLIAMLFAVAAAAWISMQIGGAIRRLSAYVSRIAEGDLTAEAPVITLRDEVGDLSKDIGGLAVSLREKLSNIILASQQVAATSEQLTASAEQTAQATEVITVAVQEIADGSEKQSRTMQQSLESSRQLDRSVDGVNRSLEDVSNTSNEAIGHARQGNLVVGESVAQIGRIEEKVSASSGYVFALGEKSAQIGDIVSLISTIATQTNLLALNAAIEAARSGEHGRGFAVVAEEVRKLAEQSRMAADQIHALITEIQGGITHAMTSMEEGNAAVKEGTVIIGQAGSAFEHIRRSIEGVHAIAQKAVQDAQQIRHETAQVVSDINVISGVAQEASQHAQGVAASAEEQNATMEEIAAASAMLSRLAEDLQDSLAIFKL
>NC_016935.1|WP_014369937.1|3250870_3251923_+|substrate-binding-domain-containing-protein
MSRLTTKAGLIGGALLLLLTACSPAEPAGQQDKTVIGFSMHNLIDERWQRDRDHFEASIREAGADVITLTAGGDENKQAAQAEKLLERGVDVLVIVAQNTESPLLGAVIEKAHSKGVKVLSYARLIKNADTDFYVSIDNVKVGELQAEEILKRAPQGNYVYIGGGQTDNNAVLLRDGSIRVLEKHKDRVTVVADDYSADWKPEEAYKHMKAALARTGGSIQGVVAANDGTAGAAVQALSELGLAGKVPVSGQDAELEALQRVVRGTQAMTIFLPIENMAKAAADAALAFAGGQEPVSNHKVPNGKKDVPSHLLEPVVVTKENVATTVVKAGYAAMEDVFQGVPKEQWPQP
>NC_016935.1|WP_013916272.1|3250441_3250657_+|hypothetical-protein
MSRQNRNQNQNENQDGFMEDTTEAARNGLQSAGEFVRNAAENTVDAAQNAAQNVADFFDGDNEENQGSSRS
>NC_016935.1|WP_014369936.1|3250019_3250367_+|hypothetical-protein
MNLMYGFGLLAAGLSIINAIFSYQAKAIDPGFGPMLWFQLRMLPLMFFSNVMIGYGVKYLYRAFQSLTFALTVSKGLEILVCVVMGYLFLKEVPTWRTYAGLGVVVCGFVLTRWK
>NC_016935.1|WP_013916270.1|3249517_3249838_-|YnfA-family-protein
MAVVLFLLAGLAEIGGGYLVWLWLREGRSLWLGLTGCLVLVAYGIIPTLQSFPSFGRVYAAYGGVFIVLAVLWGWLIDRKTPDLYDWIGAVVCTAGVAIMLWAPRG
>NC_016935.1|WP_014369935.1|3248392_3249397_+|C40-family-peptidase
MKRIITAASAALIAGVFALPQGQAQAATTSTIVSDVSFRKAPDTDAARIRYLQEDEKVTVVSKVNDYWYKVTDKNGVTGYVSSSSKYISAPRTTSTGTAAASNTGKIVSGVSFRKAADTDAARIRYLQEGETVTILDKVNSYWYKVKDKNGVTGYVSTSSKYISASYKETASAAPAGTTSGGTSSSTTSTQKVEKVIAAGMKYLGTPYEYGSDRSTVATFDCSDFVRQAFKDALGVTLPSNSRTQADYVREHSSRIVTDIDNLKRGDLVFFMSYRGSSLSAYSGMDKSAQRITHVGIYLGDGKMLNTWGTGGVKVDTITGRHWEGRFIFGGSAL
>NC_016935.1|WP_014369934.1|3246502_3248152_+|alginate-lyase-family-protein
MRNQGRRKLPVLAAAGLAAGLVFSSAAAAYPHPGGVHSEAQLASAKRNIAGGLQPWADAMKELIPRADFYLSEPPSASADFHVPGYYEDPAGHTGASEVLHTDVRAAYASALAYRLTGRTAYAEKAKAILNDWAFRNTAVSGTDGPLVMTYSGVGFIHAAELLRDYSGWSEADKTAFSNWLTNVYLARAANPIKTRSNNWGDWGIYGAMAAYYYKDDPVLLNAEITRLKNKIDSSIAADGSMPHEAGRGASGLWYTYFALAPMTAAAQIAKEAAGIDLFQWTSPGGRTIKQALDYLLFYMNRPDQWPYGANPRMPVSDEEWGYNLFEAMSDYYDEPAYKSFASVKGPIMYLASHFAWNFPSVTKGGLRLVDEKFDALTSTAAPRGWTVSKAANTSAVVWNTPTAADKSLKIWDTSTSGTASAVKVFPDQYGIIEAEWKFMYMALFPNARFGLKHAAVYAAELLTTASGLIYRSGTGSDIVLQTLSPEAWYTVKLIANPASDKTDVYVNGQLKASGVPFRSTVSALDRIEFAGGSGETGTFYIDQVKIMN
>NC_016935.1|WP_014369933.1|3245970_3246129_+|hypothetical-protein
MLNQLILWSLLSIPWFSLLFMDTTKLRRFFPVALLVTVINTLFYQAASSKWS
>NC_016935.1|WP_014369932.1|3244828_3245836_-|DUF3231-family-protein
METAHNIPLTAPEISNLWSGYQGDTLSRCVLTHFAAHVEDTEVRELIAYALELCDKHITRLLGYFETEKIPVPQGFGDEDVDPKAPRLFSDIFYLGYLLNMGKQGMALYAYSVPVSSRQDIREYLSECLASSSALYNRTLDLMLAKGVYVRPPRIPVPEAREYVHKESYFYALFEDKRPVNGPEIAHLYANIVTNLMGKALTLGFAQTAVSKDIRAYLLRGHEISGKHVEVFSSLLRDDGLPAPNYWDDGVTASTTPPYSDRLMMYHIGALSATGAVNYGVAAPNSTRRDITSVYVRLIGEIAKYGEDGAELMLKHQWMEKIPGAVERGSLVHQS
>NC_016935.1|WP_014369940.1|3256523_3257543_-|LacI-family-DNA-binding-transcriptional-regulator
MKKVTINDIARAANVAKSTVSKVMNDAPTVSPDTKRRVRAIMKQMNYTPSTIATQLARQSSSTIGMLVDLSRRADFLNHFFYTIIGGIESVAGPLHYELTISNIQSSGPDNFMNRLVRGRKVDGLIMEKSILTREQVDELLQLEFPFVSIGRIADTEGVSSVDIDNALGSGMLTDHLVEQGCRKLAFLGGEPADSIFESRSTGFHRSLKAHGLEGTVSCCEGSAAEGYRLTKELLASGYAPDGIITISNYVAFGVLQALQEANFRVPGDICVATFDDYPLAPYTTPPLTCLHLDTFELGIHAASMLMERIDGSVTGVENRLLLPTLIPRASTQRQRLKE
>NC_016935.1|WP_014650693.1|3258899_3259262_+|response-regulator
MKKILVVDDSLFMRMILKNVIQELGYEIAAEASNGMEALTKYEEIKPDLVTLDITMPEMDGMTALEEIRSRDPEAKVIMVSAMGQQALLIRAVSMGASDFIVKPFNKDRVREALKKAFAS
>NC_016935.1|WP_014369942.1|3259519_3260215_+|metal-dependent-hydrolase
MEVWYHGHSCVQLTHGGHSLIIDPFISGNGLAVTRPEDVKVDHILLTHAHADHILDTVPIAKANDATVVATFELAAYMGWQGLKTFAMNIGGRTSLGYADVEMTPALHSSGIVLEEEKKIIYGGMPGGFVIKWAGFTIYHSGDTSLFSDMKLIGERHSIDLAFLPIGDVFTMGPEDAATAAAWLGAKSVVPLHFDTFPPIRQDAEKFAAGLSQQGIRGISMQPGEKRVLEA
>NC_016935.1|WP_014369943.1|3260252_3260711_+|GNAT-family-N-acetyltransferase
MGVLAIPVETTEQLEECFGIRRRVFVEEQQVPEEEEIDEFDASPAACRHWLLRDGEEPVGTGRWRMYDGETAKLQRIAVLNSRRGQGLGRTIIEAMEQDVRKAGVPAVILDGQVQAEAFYRKLGYETISKEPFLDAGIWHVRMRKELRPEEA
>NC_016935.1|WP_014369944.1|3260921_3263273_-|EAL-domain-containing-protein
MTLTSYLLWGFYFFPGLLCLIMACEMEWRHDAKSRTAAALMLSLASFFFGEMVRALLPPEYSIAIVENWSGISAGLSIGFAYHFYTQFVRWNERLHPLLYYGICYAPPLVLALIFQTGHTELIFTGTEAVGPWNKLVIEPSGYFALMIFVLFYISAFVPLLLLARRRVPTERMKRKYTILAASSSILFIWVLVFGVLAELLPPPMPLPSLFFVYGTVIWAAMIRYLMVKYGFLTSIGNRFRILFETSPHSIMVLDSSARIRELNPMVENMFHIALSPGSSLLEIFPEEEREAMLAHFRGDFDRQERHRGLVFPLTTAKGEVMHVALDCDYFEYEDELLRMDIVRDVTDVKLTEDRIREMAYTDPLTRVGNRALFHKRFGELAKENPDRRMAVLLLDLDRFKQINDVLGHGTGDQLLQHVAESLKSAVPGPHLIARLGGDEFLVLLADLDRGEAEDLAHLILKEIRRPFVLDSQELHLTSSIGIAHYPEDGTDTETLMKHADNAMYRAKSLGKNRVSVYDLEMNRLSEARFSLEQRLRLALDRGELVLHYQPQAELSSGRIIGMEALIRWNAPGASGLVPPVEFIPVAEECGLIVPIGQWVLGEACRQNKAWYDLGQRWTVSVNVSAAQLMRSGFPEEVRAVLEQTGLPPELLILEITETAAVRDLEHTRRMLLDLAQLGVSISLDDFGTGYSSLGLIRQLPVKTIKIDRSFVQEMTDEGGNGAIAEALITLALSFGMGTVAEGVETEEQRERLARSRCAAIQGYLLSRPVPAQTITKKFAGGE
>NC_016935.1|WP_014369945.1|3263486_3265247_+|ABC-transporter-ATP-binding-protein
MAKGLPKIPIRDYVLLLSQYLKNQRRSMLLLTFLLLFGIAMQLITPQIIRYFIDTAQSQPSSRPLYYAAGLFLAATLLQQIVNVGATYVGASVGWIATNQLRLDVASHCLRLDMSFHKSQTSGAIIERVDGDINALSNFFSSFVITLLSNVILVAGMLVLLFREGWLIGTGMLFFVLFALASIQYIRRFAVPHWGKLREISARFYGFLGEHLEGTEDTRANGATGYVMFRFHQLLREWLPLRIRAFLGWASMWITTLIVFTIGSAVAFAISYSLWKQGAITLGTVYMIFYYTELMAKPIEQIRTQMEDLQKADASILRVRELLATPAAIQDGPGTPVPEGPLSVEFDRVSFSYDGSGRTLDGLSFRLEPGQVLGLLGRTGSGKTTLARLLLRFYDADEGEIRIGGTEIREPKLQQLRGRVGMVTQNIEIFQGTLRDNLTFFDDTIGDERVSGVLRELGLHGWLESLPQGLDTQLESGGGGLSAGEAQLLSFARVFLADPGLVILDEASSRLDPATEQRIERAMNRLLVGRTCIIIAHRLATIERADRILILQEGRIIEEGERETLRRDPGSRYARMLQVGMEEMLV
>NC_016935.1|WP_014369946.1|3265243_3267004_+|ABC-transporter-ATP-binding-protein
MTTFTFLWRLTRYRLGLYFLNALAWTLIYLAPIVPGLLTKAFFDMLSGSSPYELGLGMIIVLLVAAALGRVVLIIFGFMTDVQFRFRIGGLLRRNLLSHVLKEPGARAIPTSPGEAISSFRDDVEQVEETVSWSVDAFGMTLFAAVSCYILIGINAQMTLWVFLPLVLVVTVAQLSTAMLQKYRAASREATSQVTGAISEMFSTVQSIQVAGAEDRVIRRFKELGEQRREAMLKDRLLSTSLESIFSNAVNFGTGLILILAADSMRTGTFTVGDFALFVYYLNFVTQFIQNFGKFMTYFKQSTVAQERLQSLLQGAPAERLTEHHPLLLRGNLPEPQEAERRPEDRLQQLSVAGLTYRYPETGRGIEGIDFELGRGAFVVITGRVGSGKTTLVRTLLGLLPKQAGEIRWNGKRVEDPSEFFIPPHSAYTPQIPRLYSDTLQNNILLGMRADPARVGRAVHAAVLEEDLERLGAGMETVIGPRGVKLSGGQAQRTAAARMFVREAELLVFDDLSSALDVDTESRLWERLEEQRSGAACLVVSHRRSALARADRILVLKDGRVEASGRLEELLERSEELRRLWYRGEE
>NC_016935.1|WP_041619445.1|3267408_3268662_-|histidine--tRNA-ligase
MKTKEWIRPRGTADVLPEESFLWHRMENAARKVARLHHAKEIRTPLLEYEELYSRSVGDATDIVEKEMYTLTDRGGRQLALRPEGTAGTARAIIQGRLFSGPLPLKLYYIGPMFRYERPGQGRLRQHTQFGVEAVGSASPLADAELMAMALRFYEELGVTGLTVSVGSVGCVDCRRDYAAKLQSYLRQDAEALCTDCLRRLELNPLRTLDCKQPGCRSRLGQAPQLSASLCPPCRSHAGGVDAALDSLGLPYERDPLLVRGLDYYTGTVFEIQHGGSAVSGGGRYNALYAELGGPPLHAAGFGVGLERTLLLLRDTGALPDAGPQGPDVWVVPLSEAACPRVLPVLDALRRAGMAADSPLEPAGWKGALKTAVRAGASYLLVLGEEEDEAGMVEVKDLATGLQTRMPLDAFLYRCGR
>NC_016935.1|WP_014369948.1|3269200_3270727_-|LTA-synthase-family-protein
MARLFRWAAAAATLLLVLTFSASEYSKPGDPGPPPDLSEPIALTPEELRQPPNIIIVLSEAFWDPTQLPGLQFSRDPIPFFHSLQNSFPHGTMLSPMFGGGTANVELEVLTGLSYRFFPPDSVVYEQYIKQPTPSLATILSAQGYKATAIAPFHQWFFTSTDVYRYLGFSRFIPLEFFNPDEFVGPYMGDAAVARRITEESERSHGPDFIFANTMENHYHYYPGKFKRNTIDVKGDGVSAETIGLTETLAQGMSGADRMLQSLVSHYSTVREPTIIVFFGDHLPSLEKYNAYVDTGYISGTDDPDFLEKMYHVPLVIWNNYLPRGEAEKLHMSPSFLGPHVLKMAGREGSDYTDYLGELSKKLPVLPPAEHYARYGIDPALAGEYARRQAEQFAEAQRLAPQRSEGTFELGYGQPRLQDITTGGGSRSERHGPLQLTLEGGRFGLGCTVFVDGQAVPTTWRSESTLQALVPRELIGGTGTLAVQIKVLDSKENVLAVSETLSFPAQRH
>NC_016935.1|WP_014369949.1|3270940_3272143_+|DUF2087-domain-containing-protein
MKEHQPSELLWSASQEELKKGYRFEPDSGVYRCLACSAQSEQGIIYPAGEERPGLYLDAGRWMKEHIASAHGSMMHYLSSLDKKWTGLSDLQRSLLLLFHEGHSDAEIVKKVGGGSASTIRNHRFMLREKEKQARLFLAMMELLRESKEQAPKPSGAAGQAISPDEELPEGLGKLFPQGAHGPLKRWPGKESLRIRIAGLLAQRFEPHKRYTEKEVNDVLEQAWPDYAVLRRYMVEYGFMERKDDGSAYWLAEEKDSTGTEAAAEADSGSVGAKPSREKRKELVQAYQETERPAGVFRVINRRTGRMLIGSSRNLGGMKNRIWFQLESGSHPSKELQEEFRASDGEGIDFEVLEELPLRGINADEAGKLLAQLEAKWMDELKPYGERGYHPEPREGGSGR

Crispr_ID: NC_016935_9

• CRISPR_ID: NC_016935_9
• CRISPR_location: 3288859-3289441
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 10 spacers

Consensus repeat of NC_016935_9

Consensus_repeat	Method
AACNCGGAAAATCCGTGTT	CRT
AACACGGAAAATCCGTGTTAG	PILER-CR

spacers of NC_016935_9

>9.1|3288878|43|NC_016935|CRT
AGCGGCGCCGCATCGAGCTTTCAGCCGCTGCTTTACTCCTTCG
>9.2|3288940|32|NC_016935|CRT
CGGAGCGGCAAATGCAGCGAATCAGCCGGTTT
>9.3|3288991|43|NC_016935|CRT
AGCGGCGCCGCATCGAGCCTTCAGCCGCTGCTTTACTCCTTCG
>9.4|3289053|32|NC_016935|CRT
GGGAGCGGCAAATGCAGCGAATCAGCCAGTTT
>9.5|3289104|43|NC_016935|CRT
AGCGGCGCCGCATTGAGGCTTCAGCCGCTGCTTTGCTCCCTCG
>9.6|3289166|32|NC_016935|CRT
CGGAGCGGCAAATGCAGCGAAGCAGCCGGTTT
>9.7|3289217|43|NC_016935|CRT
AGCGGCGCCGCATTGAGGCTTCAGCCGCTGCTTTGCTCCCTCG
>9.8|3289279|32|NC_016935|CRT
GGGAGCGGCAAATGCAGCGAATAAACCGGTTT
>9.9|3289330|43|NC_016935|CRT
AGCGGCACCGCATCGAGCCGTCAGCCGCTGCTTTACTCCTTCG
>9.10|3289392|31|NC_016935|CRT
GGGAGCGGCAAATGCAGCGAATCAGCGGTTT
>9.11|3289219|41|NC_016935|PILER-CR
CGGCGCCGCATTGAGGCTTCAGCCGCTGCTTTGCTCCCTCG
>9.12|3289281|30|NC_016935|PILER-CR
GAGCGGCAAATGCAGCGAATAAACCGGTTT
>9.13|3289332|41|NC_016935|PILER-CR
CGGCACCGCATCGAGCCGTCAGCCGCTGCTTTACTCCTTCG

CRISPR arrays and Neighbor proteins around NC_016935_9

CRISPR arrays

The CRISPR arrays of NC_016935_9

>merge|NC_016935|9|3288859-3289441|CRT,PILER-CR
AACACGGAGGATCCGTGTTAGCGGCGCCGCATCGAGCTTTCAGCCGCTGCTTTACTCCTTCGAACACGGAAAATCCGTCTTCGGAGCGGCAAATGCAGCGAATCAGCCGGTTTAACGCGGAAAATCCGTGTTAGCGGCGCCGCATCGAGCCTTCAGCCGCTGCTTTACTCCTTCGAACACGGAAAATCCGTGTTGGGAGCGGCAAATGCAGCGAATCAGCCAGTTTAACGTGGAAAATCCGTGTTAGCGGCGCCGCATTGAGGCTTCAGCCGCTGCTTTGCTCCCTCGAACATGGAAAATCCGTCTTCGGAGCGGCAAATGCAGCGAAGCAGCCGGTTTAACGCGGAAAATCCGTGTTAGCGGCGCCGCATTGAGGCTTCAGCCGCTGCTTTGCTCCCTCGAACACGGAAAATCCGTGTTGGGAGCGGCAAATGCAGCGAATAAACCGGTTTAACACGGAAAATCTGTGTTAGCGGCACCGCATCGAGCCGTCAGCCGCTGCTTTACTCCTTCGAACACGGAAAATCCGTGTTGGGAGCGGCAAATGCAGCGAATCAGCGGTTTAACGCGAAAAATGCGTCTT

>NC_016935|9|4|3288859-3289441|CRT
AACACGGAGGATCCGTGTT	AGCGGCGCCGCATCGAGCTTTCAGCCGCTGCTTTACTCCTTCG
AACACGGAAAATCCGTCTT	CGGAGCGGCAAATGCAGCGAATCAGCCGGTTT
AACGCGGAAAATCCGTGTT	AGCGGCGCCGCATCGAGCCTTCAGCCGCTGCTTTACTCCTTCG
AACACGGAAAATCCGTGTT	GGGAGCGGCAAATGCAGCGAATCAGCCAGTTT
AACGTGGAAAATCCGTGTT	AGCGGCGCCGCATTGAGGCTTCAGCCGCTGCTTTGCTCCCTCG
AACATGGAAAATCCGTCTT	CGGAGCGGCAAATGCAGCGAAGCAGCCGGTTT
AACGCGGAAAATCCGTGTT	AGCGGCGCCGCATTGAGGCTTCAGCCGCTGCTTTGCTCCCTCG
AACACGGAAAATCCGTGTT	GGGAGCGGCAAATGCAGCGAATAAACCGGTTT
AACACGGAAAATCTGTGTT	AGCGGCACCGCATCGAGCCGTCAGCCGCTGCTTTACTCCTTCG
AACACGGAAAATCCGTGTT	GGGAGCGGCAAATGCAGCGAATCAGCGGTTT
AACGCGAAAAATGCGTCTT

>NC_016935|9|2|3289198-3289393|PILER-CR
AACGCGGAAAATCCGTGTTAG	CGGCGCCGCATTGAGGCTTCAGCCGCTGCTTTGCTCCCTCG
AACACGGAAAATCCGTGTTGG	GAGCGGCAAATGCAGCGAATAAACCGGTTT
AACACGGAAAATCTGTGTTAG	CGGCACCGCATCGAGCCGTCAGCCGCTGCTTTACTCCTTCG
AACACGGAAAATCCGTGTTGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016935.1|WP_013916316.1|3298733_3299480_+|phosphonate-ABC-transporter,-permease-protein-PhnE	unknown	unknown	gnl|CDD|273441
NC_016935.1|WP_014369953.1|3277264_3278152_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|225117
NC_016935.1|WP_014369965.1|3293697_3295200_+|tagaturonate-epimerase-family-protein	unknown	unknown	gnl|CDD|379807
NC_016935.1|WP_014369957.1|3282219_3283599_+|GntP-family-permease	unknown	unknown	gnl|CDD|225330
NC_016935.1|WP_148279744.1|3279710_3280799_+|AbrB-family-transcriptional-regulator	unknown	unknown	gnl|CDD|377472
NC_016935.1|WP_014369964.1|3292688_3293543_-|AraC-family-transcriptional-regulator	unknown	unknown	gnl|CDD|225117
NC_016935.1|WP_014369952.1|3275751_3276867_+|aminopeptidase	unknown	unknown	gnl|CDD|225191
NC_016935.1|WP_013916313.1|3296876_3297107_+|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_187298033.1|3283675_3284452_+|3-hydroxybutyrate-dehydrogenase	unknown	unknown	gnl|CDD|237100
NC_016935.1|WP_014369966.1|3295239_3296505_+|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_013916315.1|3297750_3298698_+|phosphate/phosphite/phosphonate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|270290
NC_016935.1|WP_013916308.1|3289896_3291189_-|NCS2-family-permease	unknown	unknown	gnl|CDD|225161
NC_016935.1|WP_014369959.1|3284493_3285201_+|CoA-transferase-subunit-A	unknown	unknown	gnl|CDD|224702
NC_016935.1|WP_013916317.1|3299481_3300291_+|phosphonate-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|213223
NC_016935.1|WP_014369963.1|3287600_3288812_+|cytochrome-P450	unknown	unknown	gnl|CDD|225035
NC_016935.1|WP_014369961.1|3285304_3285985_+|CoA-transferase-subunit-B	unknown	unknown	gnl|CDD|188219
NC_016935.1|WP_013916314.1|3297266_3297557_+|DUF3817-domain-containing-protein	unknown	unknown	gnl|CDD|378962
NC_016935.1|WP_014369954.1|3278307_3279597_+|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl|CDD|223745
NC_016935.1|WP_013916309.1|3291511_3292480_-|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	unknown	unknown	gnl|CDD|133463
NC_016935.1|WP_014369962.1|3285981_3287187_+|acetyl-CoA-C-acetyltransferase	unknown	unknown	gnl|CDD|180261

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016935.1|WP_013916316.1|3298733_3299480_+|phosphonate-ABC-transporter,-permease-protein-PhnE	gnl|CDD|273441	TIGR01097, PhnE, phosphonate ABC transporter, permease protein PhnE. Phosphonates are a class of compound analogous to organic phosphates, but in which the C-O-P linkage is replaced by a direct, stable C-P bond. Some bacteria can utilize phosphonates as a source of phosphorus. This family consists of permease proteins of known or predicted phosphonate ABC transporters. Often this protein is found as a duplicated pair, occasionally as a fused pair. Certain "second" copies score in between the trusted and noise cutoff and should be considered true hits (by context). [Transport and binding proteins, Anions].	1.17287e-72
NC_016935.1|WP_014369953.1|3277264_3278152_-|helix-turn-helix-domain-containing-protein	gnl|CDD|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	9.63791e-31
NC_016935.1|WP_014369965.1|3293697_3295200_+|tagaturonate-epimerase-family-protein	gnl|CDD|379807	pfam16257, UxaE, tagaturonate epimerase. This family consists of uncharacterized proteins around 500 residues in length and is mainly found in various Bacteria species, such as Thermotoga, Paenibacillus and Rhodothermus. A newly recognized enzyme from the galacturonate utilization pathway in T. maritima with tagaturonate epimerase activity.	0
NC_016935.1|WP_014369957.1|3282219_3283599_+|GntP-family-permease	gnl|CDD|225330	COG2610, GntT, H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism].	7.28663e-82
NC_016935.1|WP_148279744.1|3279710_3280799_+|AbrB-family-transcriptional-regulator	gnl|CDD|377472	pfam05145, AbrB, Transition state regulatory protein AbrB. Bacillus subtilis respond to a multitude of environmental stimuli by using transcription factors called transition state regulators (TSRs). They play an essential role in cell survival by regulating spore formation, competence, and biofilm development. AbrB is one of the most known TSRs, acting as a pleotropic regulator for over 60 different genes where it directly binds to their promoter or regulatory regions. Many other genes are indirectly controlled by AbrB since it is a regulator of other regulatory proteins, including ScoC, Abh, SinR and SigH. Hence, AbrB is considered a global regulatory protein controlling processes such as Bacillus subtilis growth and cell division as well as production of extracellular degradative enzymes, nitrogen utilization and amino acid metabolism, motility, synthesis of antibiotics and their resistant determinants, development of competence, transport systems, oxidative stress response, phosphate metabolism, cell surface components and sporulation. AbrB is a tetramer consisting of identical 94 residue monomers. Its DNA-binding function resides solely in the N-terminal domain (AbrBN) of 53 residues. Although it does not recognize a well-defined DNA base-pairing sequence, instead, it appears to target a very weak pseudo consensus nucleotide sequence, TGGNA-5bp-TGGNA, which allows it to be rather promiscuous in binding. The N-terminal domains of very similar sequences are present in two more Bacillus subtilis proteins, Abh and SpoVT. Mutagenesis studies suggest that the role of the C-terminal domain is in forming multimers.	6.88099e-70
NC_016935.1|WP_014369964.1|3292688_3293543_-|AraC-family-transcriptional-regulator	gnl|CDD|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	9.9318e-28
NC_016935.1|WP_014369952.1|3275751_3276867_+|aminopeptidase	gnl|CDD|225191	COG2309, AmpS, Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism].	1.4092e-113
NC_016935.1|WP_187298033.1|3283675_3284452_+|3-hydroxybutyrate-dehydrogenase	gnl|CDD|237100	PRK12429, PRK12429, 3-hydroxybutyrate dehydrogenase; Provisional.	3.64817e-148
NC_016935.1|WP_013916315.1|3297750_3298698_+|phosphate/phosphite/phosphonate-ABC-transporter-substrate-binding-protein	gnl|CDD|270290	cd13572, PBP2_PnhD_2, Substrate binding domain of uncharacterized ABC-type phosphonate-like transporter; contains the type 2 periplasmic binding fold. This subfamily includes putative periplasmic binding component of an ABC transport system similar to alkylphosphonate binding domain PnhD. These domains are found in PnhD-like proteins that are predicted to function as initial receptors in hypophosphite, phosphonate, or phosphate ABC transport in archaea and eubacteria. They belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.83649e-87
NC_016935.1|WP_013916308.1|3289896_3291189_-|NCS2-family-permease	gnl|CDD|225161	COG2252, COG2252, Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism].	1.93346e-140
NC_016935.1|WP_014369959.1|3284493_3285201_+|CoA-transferase-subunit-A	gnl|CDD|224702	COG1788, AtoD, Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism].	1.92984e-108
NC_016935.1|WP_013916317.1|3299481_3300291_+|phosphonate-ABC-transporter-ATP-binding-protein	gnl|CDD|213223	cd03256, ABC_PhnC_transporter, ATP-binding cassette domain of the binding protein-dependent phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all kingdoms of wildlife, but only prokaryotic microorganisms are able to cleave this bond. Certain bacteria such as E. coli can use alkylphosphonates as a phosphorus source. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	8.1933e-111
NC_016935.1|WP_014369963.1|3287600_3288812_+|cytochrome-P450	gnl|CDD|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	1.06016e-103
NC_016935.1|WP_014369961.1|3285304_3285985_+|CoA-transferase-subunit-B	gnl|CDD|188219	TIGR02428, 3-oxoadipate_CoA-transferase_subunit_B, 3-oxoacid CoA-transferase, B subunit. Various members of this family are characterized as the B subunits of succinyl-CoA:3-ketoacid-CoA transferase (EC 2.8.3.5), beta-ketoadipate:succinyl-CoA transferase (EC 2.8.3.6), acetyl-CoA:acetoacetate CoA transferase (EC 2.8.3.8), and butyrate-acetoacetate CoA-transferase (EC 2.8.3.9). This represents a very distinct clade with strong sequence conservation within the larger family defined by pfam01144. The A subunit represents a different clade in pfam01144.	4.11377e-119
NC_016935.1|WP_013916314.1|3297266_3297557_+|DUF3817-domain-containing-protein	gnl|CDD|378962	pfam12823, DUF3817, Domain of unknown function (DUF3817). This domain is of unknown function. It is sometimes found adjacent to pfam07690 and pfam03176 which are both transporter domains.	2.91066e-28
NC_016935.1|WP_014369954.1|3278307_3279597_+|Gfo/Idh/MocA-family-oxidoreductase	gnl|CDD|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	1.71145e-39
NC_016935.1|WP_013916309.1|3291511_3292480_-|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	gnl|CDD|133463	cd06853, GT_WecA_like, This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate molecule and N-acetylglucosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylglucosamine precursor. WecA participates in the biosynthesis of O antigen LPS in many enteric bacteria and is also involved in the biosynthesis of enterobacterial common antigen. A conserved short sequence motif and a conserved arginine at a cytosolic loop of this integral membrane protein were shown to be critical in recognition of substrate UDP-N-acetylglucosamine.	1.87562e-81
NC_016935.1|WP_014369962.1|3285981_3287187_+|acetyl-CoA-C-acetyltransferase	gnl|CDD|180261	PRK05790, PRK05790, putative acyltransferase; Provisional.	0

Protein sequences

>NC_016935.1|WP_014369963.1|3287600_3288812_+|cytochrome-P450
MSLDVGLDMSSPEFKNRAYALYDRWRVEEPVHSMGTTGGQQAWLITRYDDAVEALKNEERFTKNNRSLQAPGEPGLLPDKVFGLINNNLLGSDPPDHTRLRSIVSKAFTPGVAESLRGQIEEITGRLIGELRQKGGGDLIDEFAFPLPIYVICQMLGIPPEDHALFRKWSDDFIAAATDIEKIRGVQSSLEAFASYVNGLIEERKAKPQADLITELIRVQENGDRLTREELSSTIFLLIVAGHETTVNLIGNGTLALLEHPDQLALWRGNPDLDSTAVEELLRFYGPVEISTNRWVREPFEWHGKQLQRGDLLFVSLASANRDPSQFEDPARLDLTRKKNRHIAFGSGIHFCLGAPLARLEGSIAISTLIRELPNLRFVVPREEIHWRPGRLMRGLQRLPVLV
>NC_016935.1|WP_014369962.1|3285981_3287187_+|acetyl-CoA-C-acetyltransferase
MNTDREAVIVSGVRTAIGSFQGSLAGISAPELGSIVVKEALQRAGIGEEHVDEVILGSVLQAGLGQNPARQAWLKAGFGVSVPAMTVNKVCGSGLKAVMLAAQAVLLGDAEVVVAGGMENMSRAPYLLPGARDGLRLGDAALVDSLVRDGLWCASCDIHMGLTAENIAERYGLTREEQDAFAAESQRRAAEAASAGRLQAEIVPVPVPQRKGPPVLFAVDEHPRAGTTAEALARLRPAFRDGGTVTAGNASGINDGAAALVVMSAERARELGVQPLARIRGYAQAALDPAVMGLGPVDAVRRLVQKTGVALDSVELFELNEAFAAQSLAVMRELGVPADRVNVNGGAIALGHPIGASGARVLVTLLHELARREARYGIAALCIGGGQGVAMLVERVEQSAG
>NC_016935.1|WP_014369961.1|3285304_3285985_+|CoA-transferase-subunit-B
MKGQREIIVARAVREVRDGMYVNLGIGMPTLVAGAIPEGMNVMLQSENGLLGIGPYPYEGEEDPDLINAGKETVTAIRGASFFDSAESFAMIRGGHIDLAILGGMEVAENGDLANWMIPGLMVKGMGGAMDLVSGAKRIVVIMEHVNKHGQSKVRKACTLPLTGSGVVDRLITDLAVFDFTPEGMRLIELQPGVTLDEVRQRTEAAYTVAPELHNGEAAVKGGAIG
>NC_016935.1|WP_014369959.1|3284493_3285201_+|CoA-transferase-subunit-A
MDKRVASMEEAVRDIADGSLLVVGGFGLCGIPEGLIRALQAQGTKGLTVVSNNCGVDDAGLGLLLAGRQIRRMVSSYVGENKTFERQVLSGELELELVPQGTLAERIRAGGAGIPGFYTPTGVGTVVAEGKEHKSFDGRTFVLERGIVGDFALVKAWKADTLGNLVYRRTSRNFNPLAAAAGRITIAEAEIIVEAGELDPDEIHTPGIYVQRVVQGTAEGKRIERRTVRSKEGTA
>NC_016935.1|WP_187298033.1|3283675_3284452_+|3-hydroxybutyrate-dehydrogenase
MLRDRTALITGAASGIGLEIARTFAKEGARVVVTDIRTEGALQAASLLQEEGFEALGLRCDVTQEGEYAAALQAADETYGSLDILVNNAGLQHVAPLEDFPVDKFEFMIKVMLTGAFIGIKHAFPLMKRGGYGRVINMASINGVIGFAGKAAYNSAKHGLIGLTKVAALEGASHGITVNALCPGYVDTPLVRGQLEDLARTRGVPLESVLEEVIYPLVPQRRLLTVEEIADYAVLIASDKLRGVTGASLLIDGGYTAQ
>NC_016935.1|WP_014369957.1|3282219_3283599_+|GntP-family-permease
MILQVLAIVLALGLLMFFAYRGYPVIVFAPVFTLLAVVISGNALLPSYTETYMSNAANYVKSFFPIFLLGAIFGKVMELSGAASSIAQAIVRALGSQRAILSVVAACAVLTYGGVSLFVVAFAVYPFAVAIFREADIPKRLIPGTIALGAFTFTMDALPGTPQIQNIIPTTYFGTDAYAAPVLGTIGGLMVLAGGLFWLERRRKEAAQAGEGYGTGHKNEPEVLENQTYPNIWIAVLPLVLVLLFNYLLSRGALTVNNWYSAELLKSFNIANVKTVSSSWALIIALCIGIAAALCINVRAVQGKLAAGLTAAAMGSLLAIFNTASEVGFGNVVKTLPGFKLIQNWILGISDNPLISEAVSVNILAGVTGSASGGLSIALEVMGKTYLTAAQAAGISPELLHRIASMASGGMDTLPHNGAVITLLAITGLTHRQAYKDIFAITVVKTVTVFVLAIVLSMF
>NC_016935.1|WP_148279744.1|3279710_3280799_+|AbrB-family-transcriptional-regulator
MTLAVTAPGGLLFAWLHMPLSWMLGPLTAAVLWQSLIAGADRPLVWPVACRNGGLLLLGYAMGLAFTADSARQIAAQLPAMAAATLLTVGFSMLAGYWLARRAGISAQSGIIGSVPGGLSQMVLVSEETPGADGTVVAFMQTVRLLTVIFAVPFLAVHGLAGPAAPVSAVPLPAPDAAAAHPLGLAAAVVLIPLAALGAVRLKLPTPWFLGPMLASAGLTIAGLAPPHLPAPLLLAAQWSLGIYLGLGIKLSGLAGWRRLLPYSLLTGAGLVLFSLGLSWVYSLLLPMTTATAFLSTSPGGMTEMGVVASVIGADVSLVVAFQMFRILFILFAVPYLLRWGFRRAAARREEGAPAKPERPGA
>NC_016935.1|WP_014369954.1|3278307_3279597_+|Gfo/Idh/MocA-family-oxidoreductase
MTDQRKTYALVGTGGRAAFFYKAIVSDFKETSQLIAFCDVNQTRMNYANKQITDLGAEPVPTYKAHEFDRMIEETKPDVVIVTSVDRTHHTYIIRAMELGCDVMTEKPMTVDEDKCQEILDAVKRTGRQLRVTFNYRYSPHNTKIRELIEDGVIGDVHSVHFEWLLNTKHGADYFRRWHRDKRNSGGLLVHKSTHHFDLVNFWLNTQPQTVFALGDLMFYGKENAEKRGVTEFYQRATGSKNAENDHFALHLDKNESLKGMYLDAEHEDGYQRDQSVFGEGISIEDTMGVMVQYKNRAILTYNLYAYAPWEGFRVAFNGTKGRIEMEVVESSYVNSGGDQALEGAVVGKKIIVHPIFEAPYEVQVKEGKGGHGGGDPVLLNDLFGTPEPDRFNRAASHVDGAMSILTGIAGNRSLRTGQPVRVSELVRF
>NC_016935.1|WP_014369953.1|3277264_3278152_-|helix-turn-helix-domain-containing-protein
MTPTDTPRVPSVHLTDEPAFILNHTHRSASFNMESNHSHDSYEIYYMQSGSRYYFIKDRSYLVREGDLVLIEPSVLHRTTEAHSSEHERILINFKPEWLGSLLPAMEPDLLEAFGRVPVVRPEPKDRQRIELLLTTMLAEQSHPDEPGAGSALKLYLAELLLWLYRWRLKEQAAENGGRSEHPTSLHRKVSDIVQHINASFHEELSLQVLADRFHISPYYLCRIFKEATGFTLVEYIQRLRVHEARKLLAGTSMRITEVAGEVGFDSSTHFGRVFKAICGLSPLQYRKSIEGGGK
>NC_016935.1|WP_014369952.1|3275751_3276867_+|aminopeptidase
MRDPRLKELAHNLVRYSVNLQPGENILIESIGLRDQELTKCIIEEVYAAGGHPFVEYRDPAVTRALMLGGSLELYRQMAEIEVERMKKMQAYLGIRSGDNITETSDVPEDKLKLYFKEYQRPVTDQRVNHTKWTIMRYPNASMAQLANTSTEAFEDFYFRVCNLDYSKMSAAMDSLVELMEKTDKVRLVGEGTDLSFSIKGIPAIKCAGEFNIPDGEVFTAPVKDSVNGVISYNAPTIYQGTVFEKVVLRFENGRIVEATANETKKLNDILDSDEGARYIGEFAIGVNPHIQHPMKDILFDEKIDGSIHFTPGNAYESADNGNRSSVHWDMVLIQRPEYGGGEIYFDDRLIRKDGRFVVPELEKLNPENLK
>NC_016935.1|WP_013916308.1|3289896_3291189_-|NCS2-family-permease
MLAQWFQLNERQSNVRTEVTAGLTTFLTMVYIVIVNPAILSASGIPFGQVFTATVCAAVIGTLYMALFANHPIAVAPGMGMNAYFTSVVASQGVTYQAVLGTVFLAGVLFLLLSFTKLRETLIASIPASIKYGITAGIGLFIAFIGLRMSGIVTASPATLVALGDLSRPGTLLTIFGLLLTLVLMARRVKAALFIGMAVTAAAGYALGLLQFKGIAALPAAPVLFDLDVAGVFSSGLYTVVFAFLLVTIFDTTGTMIGVAEQAGLVRGGVFPRAKQALMADAVATVAGSLLGTSPSSAYVESSAGVAAGGRTGLTSLTVAVLFLLSLFFAPVVEALSSLSAITAPVLIIVGCFMMEGLAKIEWDTFDEAFPAFAILIAMPLTSSIATGIAIGFITYPLLKLVTGKGRSVHPLLYVFGVIFLVQMTFFPAH
>NC_016935.1|WP_013916309.1|3291511_3292480_-|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase
MYLYSYAAAFVMSFVIVLALIPPLRRWAFRIDFVDKPRPDQERKIHREPIPMMAALAIFAGFACTYLLFANDDWTQTTAILAGSLLILGIGTLDDWYKTRGKELAAWPKMLVQMAAAVIVYQSGIVFYGFNNPLTGQDFILWEWLQFALTVLWIFGVTTVINFTDGMDGLAGGISAISAGTLFVVAAAKGQEDSAILAIILVGASLAYLRYNKPPARVFMGDAGATLLGFLLGVIALDGAFKQATVLSLLIPILALGVPIFDNLFVVFKRWRSGKPIYMADASQAHYRLLRSGLNQKQVVMVLCLLNVCFGLTSIILLLLRV
>NC_016935.1|WP_014369964.1|3292688_3293543_-|AraC-family-transcriptional-regulator
MSETVTLHYGEEEGDFHIEHVRRTEPFARTNHWHGTYEIYYQLSGQRAYFIKDRTFLISPGDLVFIGKHQVHKTSDVGLPGHERVVINFSDRFIGGDREHPLSHPAMLAAFQSPSRVFSLKLPDQIFVQNILQKMAKEIKERATGYEIYVKLLLLELLLFSGRYSERAETTAIEHQSPVHKKISEIVRHINANYQEPMTLTGLSEQFFMSPYYLSRAFKEVTGFTFVEYVNTTRIREAQRLLKESNKKIIEIAELTGFENIAHFGRTFKKLARMTPLEYRKGER
>NC_016935.1|WP_014369965.1|3293697_3295200_+|tagaturonate-epimerase-family-protein
MSKWGTIAEALRAGTVAGVNAEGVKVYAQSLTENETTKLVMVKDTAAHTKYIAAAGEGALYDELQGEVQDGVKLAPLTHENRLVLNKYFDYTVPRAFGTQIATIGLGDRLGIASPGHIKTVRGRNIRPILAQQSIRELALTGRDYKQVVDAACFAVFQEGYKDGFGADGDHLKVEADIELALGLGFTMLTLDCSEKIDNNVEGTSAEEQAAKYAALPAEVREHYENRFLNQTFQVAGGEITFDRETLIKNVLIYAAAVDFMEHIYNTYITKADREIDFEISIDETMTPTAPESHFFVAKELYSRGLTIYSMAPRFIGEFQKGIDYIGDIAQFEKELAVHAGIADDFGYKLSIHSGSDKFSVFPLIGQYTKGRFHVKTAGTNWLEAVRTVAKVNPSLYRAMHAYALEHFEEATAYYHVTTDLSKIAPLDGVADADLADTYMNEDNARQLIHITYGILLQAKNEQGGSLFRDDFYRTLSEQEEAYEESLRSHIGKHLDLLGK
>NC_016935.1|WP_014369966.1|3295239_3296505_+|hypothetical-protein
MGVRTKEALRELVRKTVRAVPVTDAFTELYPEAFGSLMRWGLDGLLTSRALLEEAVRFHPGLTEEASSLPRPAAAELVWQTLFLDRTPLSPACREVVAVLHALGWDGRRKRLSAWRDCYDDLTAADYLDLVFARSGVTTVCMLSDPLNDAEGQVWERLHALDPRFNPVLSVDLLLRDWKKACACLRAKDYAAAEQLDNGTLEAVRSYLRYSIVRLNPLYLAASLPDGYANGGASDADRLLRECILPVAGEAGIPLGIRLEAPGPLSGGSRRAQDGEGSAEFSVLLELCRRHPGQKFLALVSGAELTLPELKAASCMPNLHLAGCAAAGTPGRGAAVRLQGCLDMLGLTMTPIYSGAEAADLLLPAWEQGRSLLESVLCERYAALADAGWSISAEDVERDAAELLGGAFWRFLGRPNPATGL
>NC_016935.1|WP_013916313.1|3296876_3297107_+|hypothetical-protein
MTQHFAAMPLVAHIPDGQPGWRLVHCPECGAACWERPDIAEAKRVIPDLTECCTECAQKAGLPLDGTQIEGGEGVR
>NC_016935.1|WP_013916314.1|3297266_3297557_+|DUF3817-domain-containing-protein
MTMRTPIGRLRVVGLLEGISFLLLLGIAMPLKYMLDLPQMVSVVGMAHGVLFVAYLLAVAHVTFVHRWSLLKVLFAVIASFLPFGTFVLDARLKRS
>NC_016935.1|WP_013916315.1|3297750_3298698_+|phosphate/phosphite/phosphonate-ABC-transporter-substrate-binding-protein
MFWKRKPFLVLTFLLIAGMLLGACGKKASNEGQQAAEGNGQGTAATEQGEFLIGVIPAQGSNQMKTGADKLAAILSEKLGRKVRAEVYPDYNGVVEAMGAGKAHMAYLGPLTYVEAHERYNVKAVVTQLINGKPFYYAYMIAPSDSPYATLDDVIKDSKNVRFAFGDISSTSGSLIPGIALKKAGVFETQQKHQFKSVTYTGDHLATALAVQNKTQDVGAIDSAYFNRLVKDGKVDGTKIKQIWQSEELFQYPWAVIESTPEKDVKIIQDAMVAITDKDILDAFGGASGFTVAKNEDYAAIRQAAIADGRVKPKQ
>NC_016935.1|WP_013916316.1|3298733_3299480_+|phosphonate-ABC-transporter,-permease-protein-PhnE
MNKILLLALAVLLLIWSGRGVGFDIALFRDLGNTYRFITEQWFPLDPADYEIALQAAVETLQISLFSTMIAIGIALPASFFAARNSTPARWLYDGFRFVFNLFRAIPELVLALLFIPTLGLGPLPAVMALIIHNTGVFGKMISETIEAIDRGPQEAVQSVGGTRLLVSLYGILPQIVPLVISHFFYRLEVAIRTCLILGVVGAGGLGQLLYNDFKQFMYQKVAFEVLLIMILVTGVDYLGAFIRKRVS
>NC_016935.1|WP_013916317.1|3299481_3300291_+|phosphonate-ABC-transporter-ATP-binding-protein
MNGKRTPAENRGGAPAHAGLEIRGLTKQYPGAKEAALQDVTLTVRPGEWVAVLGRSGAGKSSLIRCINRLIEPDSGEIRWAGQPVTGVSGSELRRLRGDIGMIFQHYNLLPRLSVLTNVIAGRFADIPLRQSLLGVFSGAYKAQAMEALRSVGLAHLAGRKVEALSGGQRQRVAIARVLMQDPQLLLGDEPVSSLDPVTAVRVLDFIGTLHRRGMTVVTNLHDVHAARRYATRIIGLAHGGIVFDGPPEELGEAELQRIYPPDDDKLQP

Crispr_ID: NC_016935_10

• CRISPR_ID: NC_016935_10
• CRISPR_location: 3667734-3667922
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 3 spacers
• Cas_protein_info: WYL,csa3

Consensus repeat of NC_016935_10

Consensus_repeat	Method
AAATAGCGGAACTCAGGTACGCTAT	CRISPRCasFinder

spacers of NC_016935_10

>10.1|3667759|26|NC_016935|CRISPRCasFinder
CGGGCTGATGTGAAGCGCGATATTCG
>10.2|3667810|26|NC_016935|CRISPRCasFinder
CGTGCTAATGCGCGAGGTGATAATCC
>10.3|3667861|37|NC_016935|CRISPRCasFinder
TCGTGCCGAGCAGGGGGGCTGGCGGTGAATGCCGGGC

CRISPR arrays and Neighbor proteins around NC_016935_10

CRISPR arrays

The CRISPR arrays of NC_016935_10

>merge|NC_016935|10|3667734-3667922|CRISPRCasFinder
GAATAGCTGAACTGAAGTGTGCTGTCGGGCTGATGTGAAGCGCGATATTCGAAATAGCGGAACTCAGGTACGCTATCGTGCTAATGCGCGAGGTGATAATCCAAATAGCGGAACTCAGGTTCGCTATTCGTGCCGAGCAGGGGGGCTGGCGGTGAATGCCGGGCCAATAAGGCATCTGAGTTCCGCTAT

>NC_016935|10|6|3667734-3667922|CRISPRCasFinder
GAATAGCTGAACTGAAGTGTGCTGT	CGGGCTGATGTGAAGCGCGATATTCG
AAATAGCGGAACTCAGGTACGCTAT	CGTGCTAATGCGCGAGGTGATAATCC
AAATAGCGGAACTCAGGTTCGCTAT	TCGTGCCGAGCAGGGGGGCTGGCGGTGAATGCCGGGC
CAATAAGGCATCTGAGTTCCGCTAT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016935.1|WP_014370143.1|3676644_3677658_-|NAD(P)-dependent-alcohol-dehydrogenase	unknown	unknown	gnl|CDD|176237
NC_016935.1|WP_013916696.1|3657695_3657971_+|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_014370134.1|3659922_3660750_+|esterase-family-protein	unknown	unknown	gnl|CDD|223700
NC_016935.1|WP_014370136.1|3666271_3667174_+|TIGR01777-family-protein	unknown	unknown	gnl|CDD|187553
NC_016935.1|WP_014370141.1|3674960_3675956_+|YafY-family-transcriptional-regulator	WYL	COG2378_WYL_CAS-I:CAS-III	gnl|CDD|225253
NC_016935.1|WP_014370131.1|3655537_3656716_+|formate-dependent-phosphoribosylglycinamide-formyltransferase	unknown	unknown	gnl|CDD|236454
NC_016935.1|WP_014370140.1|3674329_3674707_+|VOC-family-protein	unknown	unknown	gnl|CDD|366361
NC_016935.1|WP_014370133.1|3658217_3658652_+|hypothetical-protein	unknown	unknown	gnl|CDD|377503
NC_016935.1|WP_013916709.1|3671533_3672535_+|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl|CDD|223745
NC_016935.1|WP_013916717.1|3678396_3679191_+|helix-turn-helix-domain-containing-protein	csa3	COG0640_csa3_CAS-I-A	gnl|CDD|176902
NC_016935.1|WP_013916693.1|3655015_3655336_-|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|224647
NC_016935.1|WP_013916701.1|3659547_3659889_+|bacillithiol-system-redox-active-protein-YtxJ	unknown	unknown	gnl|CDD|378538
NC_016935.1|WP_013916711.1|3672770_3673712_+|aldo/keto-reductase	unknown	unknown	gnl|CDD|381308
NC_016935.1|WP_013916705.1|3667184_3667502_+|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_013916708.1|3670570_3671410_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|197666
NC_016935.1|WP_014370144.1|3677796_3678201_+|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|224647
NC_016935.1|WP_014370135.1|3660903_3666066_-|AAA-family-ATPase	unknown	unknown	gnl|CDD|226415
NC_016935.1|WP_014370142.1|3675922_3676435_-|GyrI-like-domain-containing-protein	unknown	unknown	gnl|CDD|214874
NC_016935.1|WP_013916700.1|3658975_3659485_+|metallophosphoesterase	unknown	unknown	gnl|CDD|378975
NC_016935.1|WP_014370137.1|3668308_3670480_-|DNA-topoisomerase-III	unknown	unknown	gnl|CDD|236078

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_016935.1|WP_014370141.1|3674960_3675956_+|YafY-family-transcriptional-regulator	WYL	COG2378_WYL_CAS-I:CAS-III	2.9e-62	205.6	0.0
NC_016935.1|WP_013916717.1|3678396_3679191_+|helix-turn-helix-domain-containing-protein	csa3	COG0640_csa3_CAS-I-A	3e-11	38.5	3.1

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016935.1|WP_014370143.1|3676644_3677658_-|NAD(P)-dependent-alcohol-dehydrogenase	gnl|CDD|176237	cd08276, MDR7, Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family. This group is a member of the medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, but lacks the zinc-binding sites of the zinc-dependent alcohol dehydrogenases. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P)-binding Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	1.20885e-175
NC_016935.1|WP_014370134.1|3659922_3660750_+|esterase-family-protein	gnl|CDD|223700	COG0627, COG0627, Predicted esterase [General function prediction only].	1.32816e-38
NC_016935.1|WP_014370136.1|3666271_3667174_+|TIGR01777-family-protein	gnl|CDD|187553	cd05242, SDR_a8, atypical (a) SDRs, subgroup 8. This subgroup contains atypical SDRs of unknown function. Proteins in this subgroup have a glycine-rich NAD(P)-binding motif consensus that resembles that of the extended SDRs, (GXXGXXG or GGXGXXG), but lacks the characteristic active site residues of the SDRs. A Cys often replaces the usual Lys of the YXXXK active site motif, while the upstream Ser is generally present and Arg replaces the usual Asn. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	3.93668e-121
NC_016935.1|WP_014370141.1|3674960_3675956_+|YafY-family-transcriptional-regulator	gnl|CDD|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	1.24688e-61
NC_016935.1|WP_014370131.1|3655537_3656716_+|formate-dependent-phosphoribosylglycinamide-formyltransferase	gnl|CDD|236454	PRK09288, purT, formate-dependent phosphoribosylglycinamide formyltransferase.	0
NC_016935.1|WP_014370140.1|3674329_3674707_+|VOC-family-protein	gnl|CDD|366361	pfam00903, Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily.	2.06284e-10
NC_016935.1|WP_014370133.1|3658217_3658652_+|hypothetical-protein	gnl|CDD|377503	pfam05360, YiaAB, yiaA/B two helix domain. This domain consists of two transmembrane helices and a conserved linking section.	1.39099e-14
NC_016935.1|WP_013916709.1|3671533_3672535_+|Gfo/Idh/MocA-family-oxidoreductase	gnl|CDD|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	1.76656e-81
NC_016935.1|WP_013916717.1|3678396_3679191_+|helix-turn-helix-domain-containing-protein	gnl|CDD|176902	cd08893, SRPBCC_CalC_Aha1-like_GntR-HTH, Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain. SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. Some proteins in this subgroup contain an N-terminal winged helix-turn-helix DNA-binding domain found in the GntR family of proteins which include bacterial transcriptional regulators and their putative homologs from eukaryota and archaea.	5.98335e-17
NC_016935.1|WP_013916693.1|3655015_3655336_-|helix-turn-helix-transcriptional-regulator	gnl|CDD|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	1.75466e-40
NC_016935.1|WP_013916701.1|3659547_3659889_+|bacillithiol-system-redox-active-protein-YtxJ	gnl|CDD|378538	pfam11009, DUF2847, Protein of unknown function (DUF2847). Some members in this bacterial family of proteins with unknown function are annotated as YtxJ, a putative general stress protein. This cannot be confirmed.	1.59685e-48
NC_016935.1|WP_013916711.1|3672770_3673712_+|aldo/keto-reductase	gnl|CDD|381308	cd19082, AKR_AKR10A1_2, AKR10A family of aldo-keto reductase (AKR). Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.	9.65773e-153
NC_016935.1|WP_014370135.1|3660903_3666066_-|AAA-family-ATPase	gnl|CDD|226415	COG3899, COG3899, Predicted ATPase [General function prediction only].	7.46754e-141
NC_016935.1|WP_013916708.1|3670570_3671410_-|helix-turn-helix-domain-containing-protein	gnl|CDD|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	1.61285e-25
NC_016935.1|WP_014370144.1|3677796_3678201_+|helix-turn-helix-transcriptional-regulator	gnl|CDD|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	1.0977e-34
NC_016935.1|WP_014370137.1|3668308_3670480_-|DNA-topoisomerase-III	gnl|CDD|236078	PRK07726, PRK07726, DNA topoisomerase 3.	0
NC_016935.1|WP_014370142.1|3675922_3676435_-|GyrI-like-domain-containing-protein	gnl|CDD|214874	smart00871, AraC_E_bind, Bacterial transcription activator, effector binding domain. This domain is found in the probable effector binding domain of a number of different bacterial transcription activators.and is also present in some DNA gyrase inhibitors. The absence of a HTH motif in the DNA gyrase inhibitors is thought to indicate the fact that these do not bind DNA.	3.2027e-22
NC_016935.1|WP_013916700.1|3658975_3659485_+|metallophosphoesterase	gnl|CDD|378975	pfam12850, Metallophos_2, Calcineurin-like phosphoesterase superfamily domain. Members of this family are part of the Calcineurin-like phosphoesterase superfamily.	1.69343e-37

Protein sequences

>NC_016935.1|WP_013916705.1|3667184_3667502_+|hypothetical-protein
MLIYGSTDIHELRFEELTARVERRDEQWIDVEVGFRVAGPDAVPEDITELGALLVVTYRGDIAEIAPQDEGRDCEYQFTESEKAQLREFYEREVRPQVLQAAGQE
>NC_016935.1|WP_014370136.1|3666271_3667174_+|TIGR01777-family-protein
MKVAIAGGTGFIGGHLTRYYAERGTEVVLISRSARASDKERVKYVTWSELEKNVSAVEGAEAVINLAGESINQRWSEAAKARILDSRLDSVRRVADIAGRLERKPVLVNASGMSVYGLSDTESFSEESPHRLDHFLAEVVEKWEAEIRRVPAARTVMLRVGVVLGRDGGAYPKMRLPFVFGAGGRIGSGRQWLSWIHVDDIIRLIDYCVTQEEMAGPVNATAPEPVTNDAFGRALAKVMGRPYLFPVPGLVMKLIFGEMSMLLLEGQKVLPQAALSGGFRFTYPTIEEALRSLERRAKGG
>NC_016935.1|WP_014370135.1|3660903_3666066_-|AAA-family-ATPase
MALQLNEGAAERLDDTAAATWFRTEDSGGRRRLVKALKAEYGTPGEVQRLRLELEKGRRLGFPEVLLPLGIVTFRGTPALVTEAAEGVLLSSVLSPVPAAPEVFLPLALSMTDAVRQLHKHKFAHTALSHQAFFIDKDAAGGRVRLTELHSLVSLGSPHDPAAPAESAVPPQPERNPFLAPEQMHDPAAGRVNVRPDHRTDLYALGVLFYRLLTGLFPSLPDIGSDGSAPSPVPPAELAVSVPEVLSAVVMKLLTRQPDQRYPSAFALHRDLAKCLEQWSAAGTIEAFALGTVAGSDHFAISETIYGRETELEQLHAAYGRCLSGSLQTAFVSGLSGIGKSYLIHEFQKGLTPGSALYVHGKFDQYKRESPYYAIRQIGRQLMQHLLQQPPEELQLLKERIRDAVGPNGQILLEMNPDLEAVIGKQPPLTKLPPAEMHNRFILTIRQYTSVFASQEHPLVLFLDDLQWADPASLQLVSEFLLEMPFPYMLFIGAYREREVTDSHPLRSLIGKLGRSRTAPVEIRLEPLQEPHVARLLEDTLQPSKQDPRELAGLIMSKTKGNPFFTKQFFRSLYDQHLLRFDDRSCCWAWDTDRIKELHITDNVVDFMISKIRRLSESMQHLLMHAACLGQQFTPEVLSLVTGYDGDRTALLLKQAVDDSLLLRVVGGRRTSSAEAVTSYKFMHDRVYQAVYSLLPDSDKKRIHLHIGRLLQAYYAEEEHDLTVFEVTDQLNLGSDGITSPPEREDLAELNLRAARKAKGNSAFDTAYRYASQGVQLLGEEAWSSRFELAYALRLEMAELEYLCGHFGEAKASFETVLRLSRTKLEKADVYNLMIILHTHIGEHEQAVRLGLEGLKLFGLSLRPKIGKGSILWEMFKSRIHLGLRSQDDLLDHYPMSEPEHEAVMRFLVNLIPSAYFLDADLYVYLMLRMFNYSLMHGHSDGSAYAYSTYGVILSAVFGRLKAGWEYGRLSVQLSDIYPNPAIKSKVYFAYGGFSNNIREHIEANVGHLRKAYQYGVESGDLVYAGYSIAFSFFMQVLKGDTLPEILQESEKYRQFVHQAQDRDVIWIYTVIQRYILSLKETAGAPNAPQEPLLSPEEAQIVRGLSNKAVVHTFYGLQAQSFYLLNHLEEARLICEETEANLGQMFGFPHIELHHFQYGMVLASLYDHAGNALQMKYRKRIRKSLKILGKWAAHSPSNYLHMNLLLQAEYDRITDKRMQAAEKFDLAIQAAARSGFLPREALANERAALFYLRTGRIKIAKAYLLDARSLYERWGAARKVAQLEALYPGLLGWASSADVLPAACGVLKATPPVTYQTVFHHMLDCMMSQMLEYARADKALLMLEQDGQLQIEAEKSLKDPFRSLHSTPVEEGVPAAVTAVDYVKQSGEPLLLKEAPDAGLFGNDPYIREIRPQSLLCLPLTGRGEAAGILYLESRTAAHAFQPDRFGRLKLLAAAAAELVRRARLTASLEVKEDLLPQAHELGRQQSRPQPVVPESRRGTARDGTPSSRQLAQTQFIRRLQGVHALLALNKTETAQESIAVWCEELVQMTLADSVAFPALRSALLSLLPAITAAGIELQVDGRLDCLFERLSLPPSLFAGTLQPLLQHALDAAAARESQRVVRLTLTESESHYGLAVLYSGSPVGEEPRHRPFEKAPPLRAEDSPVVPLVQSLQHMLQPYGGELQCRYEAGRGMIFTLRLPKRAAGDRVPREAAASGLDH
>NC_016935.1|WP_014370134.1|3659922_3660750_+|esterase-family-protein
MAVQSFSFFSGALYARKVCQVYLPPSYDASEDTRYPVIYLLHGLNGDETSWLVKGGAEAQLDRLMGDGTLRESIVVMPSDGGYGHGTFYVNWYDGTGRFEDYFLYDLMPSIDREFRTIADRSSRALCGLSMGGYGAFVLALRNPELFGAAASIAGALMSTGLMTEQFLRSEVSRLVGPVHGPFARELDLHVLAARMLREEQRPELHFNCGFSDYLYPLNSAFKALLDQLNYPHDYAEYEGEHNWDYFGGHLAEALAFIERSFAGAPAGEAPAEIG
>NC_016935.1|WP_013916701.1|3659547_3659889_+|bacillithiol-system-redox-active-protein-YtxJ
MSKWKEITTKEEWEQYYEGSGSKPFVVLKHSTACPVSFNALQEYEAYLGKTPNEQVDYILVKVIESRPVSNQIAEETGVKHASPQVLYIKNKETVWNTSHWSITEEHLTAVLN
>NC_016935.1|WP_013916700.1|3658975_3659485_+|metallophosphoesterase
MRIGVVSDTHMFGRGAALPAALVRGLQGTDLILHAGDWMDERVIALFEAIAPVDGVAGNNDGPEIIRRFGRRKVLELAGYRIGLVHGDGGRSTPETAYAAFRTKEGEVLADVVIFGHSHTPFHEVRGGQLLFNPGSPTDKRRQPLYSYGILTLGESVSAELFTYEDKSP
>NC_016935.1|WP_014370133.1|3658217_3658652_+|hypothetical-protein
MRKRNTSAFTFLAWTSFASALLAMFIGITTLEETLSVKGYYAVSALYLTMASFVLQKTVRDNQEDGTQARRRNTGAFTFLSWTAFSTALLAMFIGIVNLEQPLSVQGYYAVTALFLTMSSFVLQKTVRDNKEDSEMYAEPDTHE
>NC_016935.1|WP_013916696.1|3657695_3657971_+|hypothetical-protein
MAYNPQVTDAKVVSYNPKNGLFEIVANLKDRTVCRLTYESDETGGAKATHISRLLQEPCPICRKDFLCNCMDKFKENIAGQALEHTGVPTA
>NC_016935.1|WP_014370131.1|3655537_3656716_+|formate-dependent-phosphoribosylglycinamide-formyltransferase
MYGAPLSAGAHKIMLLGSGELGKEVIIEAQRLGVETVAVDRYANAPAMQVAHRSYVISMLDGEALRELIEKEKPDLIVPEIEAIATQTLVELESEGYRVIPTATAARLTMDREGIRRLASETLGLPTARYAFADTLDELKAAVAEIGTPCVIKPIMSSSGKGQSVCRTPDDIETSWNLAMEGGRAKKARVIVEEFIRFDSEITLLTVRSASGTSFCAPIGHIQKDGDYIESWQPHFMSSAQLEEAQEIAAKITDALGGTGLYGVELFLAPDKVYFSEVSPRPHDTGMVTMASQDLSEFALHVRAILGFPVPTIRLLTPAASYTLKADRDAETFRIGGLPEALALPNTQVRVFGKPETKPGRRMAVALSTGETVEEARRLAKEAAGNLRIEYS
>NC_016935.1|WP_013916693.1|3655015_3655336_-|helix-turn-helix-transcriptional-regulator
MADQQPHTMCPKFEAAFEILGKRWTGLILCALLGGPCRFKDISEMIPGMSDRMLAERFKELEAAGLIVRHVYPETPVRIEYELTGKGKALKPVMEAVQQWGEAWVN
>NC_016935.1|WP_014370137.1|3668308_3670480_-|DNA-topoisomerase-III
MKSLVLAEKPSVAKEIARVLGCQQKHKHYMEGPQYVVTWALGHLVTLAEPEEYDLKYKTWNLEDLPLLPSKMKLKVIRETTPQFKAISQLAQRGDLKELIIATDAGREGELVARWIMELVRWRKPYKRLWISSQTDKAIRDGFAQLKPGPAYDPLYRSAVCRAEADWLIGLNITRALTCKHNAQLAAGRVQTPTLAAMMDREAQIRSFQAKDFWMLRAQLGSFQALWRSQAHPDGRLFDKAAADTLLERLKTARSAKVSALKVSEKSEPHPLAYDLTELQRDANKRLGFTAKQTSNVLQRLYEQHKLVTYPRTDSRYLSSDMVSTLPDRLKALLGTPYGASAKGLLARPLPVTKRIVDDSKVSDHHAIIPTDERPQLQLLGADERRLYDLIVRRFLSLFFPAFRYDETAVTLDIAGESFHAKGRIVKDQGWKAVYDGSSAPSEADDDDAPEEEPSSLQSLPALQLGTELKDLRLSQQKGTTKPPGRYTEAGLLSVMEKQGLGTPATRADIIEKLLSTDTIERRMNTLQPTGKGVQLMELVVPELRSSELTASWERELERIAKGQGDPDAFMAGIRKQTEAIVRDVKNSSAEYKPHNLTHSKCPDCGSPLQDIKGKRGRMLVCSSRECNYKRAAEAQLSNKRCPQCRKKMEIHTGKAGKYAQCRPCNVIEMLNDTGGAGGRGKAGKRQQSQLAEQYSDNAKLPSALEEALKAALGKGSGGSDDE
>NC_016935.1|WP_013916708.1|3670570_3671410_-|helix-turn-helix-domain-containing-protein
MKRQSMLPTLNRTEFMILPESVGWYTEMPDHEVSRKAGVLNNFSIHIVLGGRGCVEHDRSVYTLQRGDAFLYFPLTEQRYYSSQDDPWEVRWVHFYGSGLREYLIERGFSRSPLWKLRQTKPVEDALDALLVEAEARGFLGLTRLSTLTYAVLAEFVSEAAPWSDPRSAEPGSRVLDLLPAMRAEACLPFDLQEWADRAGVSTYYFCRLFKKATSMTPMTFITLSRLQKGKQLLLEQPDLTVKDIAEQTGYPSVSYFNKRFLEQEGMTPTDYRQLYRKE
>NC_016935.1|WP_013916709.1|3671533_3672535_+|Gfo/Idh/MocA-family-oxidoreductase
MSEKKIRWGILGCANIAVRAVIPGTQKSETGVVAAIASRGIGKAQETAEKMGIPTAYGSYEELLADESIDAVYIPLPNHLHKEWTIKAAEAGKHVLCEKPAALNAEETREMAAACEKAGVIFAEAFMYRYHPRYQMIREIIASGEIGEVRGIHGAFTFNNAKDTGNVRYQQHMGGGSIYDVGVYPISAARFILGQEPEAATVHGFFSPEHDGVDMMASGLLEFPNSVALTFDCGMWAAGRNVLEILGTDGRIEVPSAFVTNGSERDHFIVHAKGESREVQVPYLNQYALQADAIGRSVLYGEPMPFGPQDAVNGMRVVDACLTSARERRRIEL
>NC_016935.1|WP_013916711.1|3672770_3673712_+|aldo/keto-reductase
MRTITIQGLDKPVSCLIKGSDYFREDVYEKAARNLDAYFAIGGNTIDTAYIYCGGESEKTIGRWMAERGNRDQVIILTKGAHHNKDGPRVNPEAIEADLQESLQRLGTDYVDLYALHRDDPSVPVGIIMDALNEHIQAGRIRAIGGSNWTTARLQEANEYAAQHGLVPFTFSSPNLSLAKANEPFWSGCVSADSSDCAWHEQHQLPLLSWSSQARGFFTGRFTPEVRDNADLVRVFYSDANWDRLRRAEQLAAERGVTAIQIALAYVLNQPFPACALIGAQTPEELESCRQGAEIVLTREELEWLEHGTPVRA
>NC_016935.1|WP_014370140.1|3674329_3674707_+|VOC-family-protein
MPIVNRVDTIFVHVTDLERSISWYSRLLGLDVREGRHEGPIYTLDMGQGRPGITLDNHCFDENYVFTPSNQPLFNLSASDIHEAYRHVTELGAEIVSGIVTYPDLAEFSFQDPDGNIIMVCTCFS
>NC_016935.1|WP_014370141.1|3674960_3675956_+|YafY-family-transcriptional-regulator
MTKSKRLMELMIAVNKRRRFTVRELAEEFGVSTRTIMRDLQVLDELGLPLYAEYGPHGGYRVLNERLLPPIMFSEQEALAMFFAYQSLQHYGALPFSEESVTALKKFYYYLPDDTKQKIDRLQERVVFWTPKRQAAVPHLKLLLDASLQGRPLRITYDSREGPGERAIQPIGVYSYNGYWYCPAYCFRKQRYLLFRVDRVLQAEPAGEEHPAVDLSEYTITDWFLPPPQQPPGPGGDAHGLLQLEVRLTKDGVRRCRWESWFQEELVVGEEGEGLLRIRIRHDEMDYYTGYFLSLGADAVVVQPPELVSRLREAVRKLYDAYGAGETAGPP
>NC_016935.1|WP_014370142.1|3675922_3676435_-|GyrI-like-domain-containing-protein
MKPRIEKHGEFAAVGTKGQHRLTEGVIPTIAGQWDAFMRRAAEIPGRGPATLGICWGIEAASGEPFDYLTGALVEEMPPELPSGMTAVTLEPRLYAVFTHRGPVARLDATYASIQAWLESNGTYRRADAPDFEYYDHRYASAEPESSEFDIYIPVTEPACYGGPAVSPAP
>NC_016935.1|WP_014370143.1|3676644_3677658_-|NAD(P)-dependent-alcohol-dehydrogenase
MRAFEIQGGFGLERITLAERPKPAPGPGEVLLRIRAASLNARDLGVVGGFYVGAETLPLIPVSDGVGIVEELGEGVTRVKPGDRVCPIFVQDWLAGTPTEAMLGSTLGGPRDGVLAEYGVFPQGSLVHVPEHLTDEEAASLPIAALTAWQAVVTEGRVRAGDTVVVQGTGGVALSALQFAKLHGARVIVTSSSDVKLERAAALGADLGINYVKSPQWDQEVLRLTDGRGADHIVDLGGAATLNASLAAVRPGGRVSIVGVLSGVTAAGLDLIPAIRKKVTLQGINVGSHGMFEDMNRALALSGVRPVIDRVFPFTEAVQALRYMQEGVHFGKICIRL
>NC_016935.1|WP_014370144.1|3677796_3678201_+|helix-turn-helix-transcriptional-regulator
MRTDGRPEKDISVTVCSYSLALDVIANKWKPLVIYALENGSQRYGDMKRRIEGVVPENGLTETLRGMERDGLVVRKVHPAVPPAVEYTLTPLGRTLIEPLQALHVWAKAHHEDVLSARERYDGQDGQDGQTGGA
>NC_016935.1|WP_013916717.1|3678396_3679191_+|helix-turn-helix-domain-containing-protein
MTTVQSKDSAIFLVLADPRCRELLQRLAASPGLSVSGLSDELELPRAAVLKHLKMLEEAELAASRRIGREKLYSADRERLRGLMERLLGRPEDTRGGRLGELKRMLSEEKQRSVRMLPRQTYGTLIRSSPARIWEEVLSPEQPAGFWRGCRLILGGGELSPYRLERPDGREEARGMVTAAEAQRRLELTWGSPDESEAGTAEGRLALELERLPGRPEVCRVILVLTAEIRTEDSIRAADGGWPGRLAGLKSYVETGEGMWEEKP

Crispr_ID: NC_016935_11

• CRISPR_ID: NC_016935_11
• CRISPR_location: 5550944-5551037
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_016935_11

Consensus_repeat	Method
GGTCACTGTCAAAACCATATATCCT	CRISPRCasFinder

spacers of NC_016935_11

>11.1|5550969|44|NC_016935|CRISPRCasFinder
CGCTGGGTATAGAAGACCCCATTTCCGCTTGGCTTCGCACAACC

CRISPR arrays and Neighbor proteins around NC_016935_11

CRISPR arrays

The CRISPR arrays of NC_016935_11

>merge|NC_016935|11|5550944-5551037|CRISPRCasFinder
GGTCACTGTCAAAACCATATATCCTCGCTGGGTATAGAAGACCCCATTTCCGCTTGGCTTCGCACAACCGGTCACTGCCAAAACCATATATCCT

>NC_016935|11|7|5550944-5551037|CRISPRCasFinder
GGTCACTGTCAAAACCATATATCCT	CGCTGGGTATAGAAGACCCCATTTCCGCTTGGCTTCGCACAACC
GGTCACTGCCAAAACCATATATCCT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016935.1|WP_014371074.1|5548094_5549738_+|GGDEF-domain-containing-protein	unknown	unknown	gnl|CDD|143635
NC_016935.1|WP_014371079.1|5556732_5556909_-|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_014371072.1|5546947_5547166_-|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_014371078.1|5555218_5556634_+|PLP-dependent-aminotransferase-family-protein	unknown	unknown	gnl|CDD|224089
NC_016935.1|WP_014371070.1|5544167_5545019_-|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223669
NC_016935.1|WP_014371071.1|5545120_5546848_-|alpha-keto-acid-decarboxylase-family-protein	unknown	unknown	gnl|CDD|226470
NC_016935.1|WP_014371073.1|5547247_5547925_-|SOS-response-associated-peptidase	unknown	unknown	gnl|CDD|376837
NC_016935.1|WP_041618457.1|5558614_5559790_+|DUF4850-domain-containing-protein	unknown	unknown	gnl|CDD|292760
NC_016935.1|WP_014371081.1|5558200_5558506_-|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_014371084.1|5560703_5562161_-|DUF5050-domain-containing-protein	unknown	unknown	gnl|CDD|379846
NC_016935.1|WP_013918871.1|5539825_5540920_-|AI-2E-family-transporter	unknown	unknown	gnl|CDD|223701
NC_016935.1|WP_013918883.1|5550505_5550805_-|DUF2325-domain-containing-protein	unknown	unknown	gnl|CDD|378383
NC_016935.1|WP_014371069.1|5541635_5543024_-|MATE-family-efflux-transporter	unknown	unknown	gnl|CDD|240539
NC_016935.1|WP_014371083.1|5559926_5560625_+|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_014371085.1|5562184_5563057_-|DUF4362-domain-containing-protein	unknown	unknown	gnl|CDD|372994
NC_016935.1|WP_014371080.1|5556980_5558075_-|DUF4163-domain-containing-protein	unknown	unknown	gnl|CDD|377924
NC_016935.1|WP_014371075.1|5549893_5550268_-|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_014371077.1|5553617_5555072_-|amino-acid-permease	unknown	unknown	gnl|CDD|236823
NC_016935.1|WP_013918874.1|5541226_5541415_-|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_014371076.1|5551170_5553471_-|ATP-dependent-helicase	unknown	unknown	gnl|CDD|223288

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016935.1|WP_014371074.1|5548094_5549738_+|GGDEF-domain-containing-protein	gnl|CDD|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	7.79875e-54
NC_016935.1|WP_014371070.1|5544167_5545019_-|alpha/beta-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	8.78663e-24
NC_016935.1|WP_014371071.1|5545120_5546848_-|alpha-keto-acid-decarboxylase-family-protein	gnl|CDD|226470	COG3961, COG3961, Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only].	0
NC_016935.1|WP_014371073.1|5547247_5547925_-|SOS-response-associated-peptidase	gnl|CDD|376837	pfam02586, SRAP, SOS response associated peptidase (SRAP). The SRAP family functions as a DNA-associated autoproteolytic switch that recruits diverse repair enzymes onto DNA damage. We propose that the human protein Q96FZ2:UniProtKB, the eukaryotic member of the SRAP family, which has been recently shown to bind specifically to DNA with 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxycytosine, is a sensor for these oxidized bases generated by the TET (tetrahedral aminopeptidase of the M42 family) enzymes from methylcytosine. Hence, its autoproteolytic activity might help it act as a switch that recruits DNA repair enzymes to remove these oxidized methylcytosine species as part of the DNA demethylation pathway downstream of the TET enzymes.	1.5276e-110
NC_016935.1|WP_041618457.1|5558614_5559790_+|DUF4850-domain-containing-protein	gnl|CDD|292760	pfam16142, DUF4850, Domain of unknown function (DUF4850). This family consists of several uncharacterized proteins around 250 residues in length and is mainly found in various Acinetobacter species. The function of this family is unknown.	5.02501e-82
NC_016935.1|WP_014371084.1|5560703_5562161_-|DUF5050-domain-containing-protein	gnl|CDD|379846	pfam16472, DUF5050, Domain of unknown function (DUF5050).	1.97235e-33
NC_016935.1|WP_013918871.1|5539825_5540920_-|AI-2E-family-transporter	gnl|CDD|223701	COG0628, yhhT, Predicted permease, member of the PurR regulon [General function prediction only].	7.48636e-59
NC_016935.1|WP_014371076.1|5551170_5553471_-|ATP-dependent-helicase	gnl|CDD|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	3.39595e-114
NC_016935.1|WP_014371069.1|5541635_5543024_-|MATE-family-efflux-transporter	gnl|CDD|240539	cd13134, MATE_like_8, Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.	7.3383e-177
NC_016935.1|WP_014371085.1|5562184_5563057_-|DUF4362-domain-containing-protein	gnl|CDD|372994	pfam14275, DUF4362, Domain of unknown function (DUF4362). This family of proteins is found in bacteria. Proteins in this family are typically between 93 and 146 amino acids in length. There is a conserved IRIV sequence motif.	5.06658e-14
NC_016935.1|WP_014371080.1|5556980_5558075_-|DUF4163-domain-containing-protein	gnl|CDD|377924	pfam07833, Cu_amine_oxidN1, Copper amine oxidase N-terminal domain. Copper amine oxidases catalyze the oxidative deamination of primary amines to the corresponding aldehydes, while reducing molecular oxygen to hydrogen peroxide. These enzymes are dimers of identical subunits, each comprising four domains. The N-terminal domain, which is absent in some amine oxidases, consists of a five-stranded antiparallel beta sheet twisted around an alpha helix. The D1 domains from the two subunits comprise the 'stalk' of the mushroom-shaped dimer, and interact with each other but do not pack tightly against each other.	2.04364e-18
NC_016935.1|WP_014371078.1|5555218_5556634_+|PLP-dependent-aminotransferase-family-protein	gnl|CDD|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	1.0201e-122
NC_016935.1|WP_014371077.1|5553617_5555072_-|amino-acid-permease	gnl|CDD|236823	PRK11021, PRK11021, putative transporter; Provisional.	3.69695e-54
NC_016935.1|WP_013918883.1|5550505_5550805_-|DUF2325-domain-containing-protein	gnl|CDD|378383	pfam10087, DUF2325, Uncharacterized protein conserved in bacteria (DUF2325). Members of this family of hypothetical bacterial proteins have no known function.	2.04691e-16

Protein sequences

>NC_016935.1|WP_013918883.1|5550505_5550805_-|DUF2325-domain-containing-protein
MTMKRVAIIGGSQTGTFKKLGEKRGLLVEHHNGKTGGGPVDEYFQRIINKADVIIVLRGAIKHTSMWAVRELAEKKGKKIDYHDGFGASGALEKALQLV
>NC_016935.1|WP_014371075.1|5549893_5550268_-|hypothetical-protein
MIKTVWLGLLLALNPAADQTATQPVDVADYYGTNPTLGDTSFAKTVSPHAGVPQFRVQGANPQQQADLTDGRWGDPGDVPVYRPAVAPANENQGSHWLGLAGLLGLLGLRRGRAKRPASPTEEG
>NC_016935.1|WP_014371074.1|5548094_5549738_+|GGDEF-domain-containing-protein
MIKLRTLLILTITGIVILLTSLLGVLFTRHSTNEIKKEIGHSLAGTAYQMSDKLDNFMWSRAGEMEILTTLDIFKQGGDIPGVQTALDQLQTSFPSFSWVGFMNTEGQVLAATDGILVGTNIASRPVFKEGIKGRFIGDVHEAVLLAKLLPNPTGEPLQFVDISLPVKDHGGRTIGVLAAHMSWEWSREVQRTILEPQLHRSENLELFIVSRTDHTVLLGPEDMVGKPLEIDSVNRAQAGGSGWELAAWPDGRSYLTGYAYGDGYLSYEGLGWTVLVRQPESAAFARVAGLRSDFALAGTLAAMLFAVIGWFLAARITRPINSLTEAADRLRTGEAAELPENRGFREMYILSRSLRSLVESLARTENELGDMKNLAHFDPLTGLPNRVALESYLETTLEEVEPRTETLAFLYLDLDGFKKVNDTLGHHTGDILLQKVAKRLISLQQAGNITVRLGGDEFLHILRFPKESAFEETKRAAEEIIALLNKPFLVDYNRISIGCSIGAAFYPDQDENAGQILRIADECLYRSKRAGKNCVSFSDELTMKLQ
>NC_016935.1|WP_014371073.1|5547247_5547925_-|SOS-response-associated-peptidase
MCGRFTLTVSPEAILEQFDLPGGLEEYHPRYNVAPGQQVWAIVHDGEAKRIRQLHWGLVPFWAKDPKIGYRTFNARSETAAKKAAFREPMKHSRCLIVADGFLEWRVRSGKAKQPVRFRLKSREVYGFAGLWETWRGKDGTEMATCTILTTQPNEIVREVHDRMPVILPREAERLWLDPGVEDPGHLQGLLQPYPADEMYAYEVSPLIGNVRNDSAELLEELNSK
>NC_016935.1|WP_014371072.1|5546947_5547166_-|hypothetical-protein
MRPLVNDIELCTALVYQTEILVFAGREWVHRGKILAFTEHSVQIGERRFDRAGCSFWMPQETEEEEVIAVCG
>NC_016935.1|WP_014371071.1|5545120_5546848_-|alpha-keto-acid-decarboxylase-family-protein
MSAKTDKDRSSAGRAEEAAVSLGRFLFDSLKREGVTEIFGVPGDYNFTLLDELERCEGMRFIGGRNELNAGYAADSYARLRGLGALITTFGVGEMSAANAVAGAYSESVPLVHIVGTPKSAAQRERRLMHHSLLDGDYEVFRRAYGEITAYTAVLTPENAAAEIPKAIRTAKEKKKPVYLAVAIDLVDRPVVVQAHGEPEPKLQRRTDPAVLEAASAHAKRLLGAAGRAVILSDLPVQRFGLGEPVQRLAEALNVPAASTMLGKGSFDEGHPNYIGVYGGEFGSEDVRSIVEEAGCLIAVGLVRSDGNLANFTAKLDTAQLIEIQPDSVRIGEALYPGIRAEEMLRALEESGFRGGELPRVRHPYDEPAGGPGDAVTAKTYLPRFQRMLKEGDVVVVETGTLAYGMSEVRLPKGAAYIHQGAWQSIGYALPAAFGAAVADPQRRIVLFTGDGALQLTVQEISSMLACGGRLILFVLNNRGYTIEKYLNVRTERQPYNDIPEWSYTRLAEAFGGEAYTARVRTNGELDAAMAEAEAQCGRRLCLIELVPEDPMDAPPYLKRKRSYLEAQEAQRAKG
>NC_016935.1|WP_014371070.1|5544167_5545019_-|alpha/beta-hydrolase
MSSSGIIDMDGFPLAYRIEGEGPPVLIVGSETYYPRLFSQELRKKLQLIFVDHRAFVKPSRSIKPEDYTLERIVQDMEVIRTTLKLGRVTVLGHSGSAFIALEYARTYPGHTATAVLLNSAPTNSAERQQGSLRHFDETASPERKAKFERDIALLPGDIEREPERRFAHACIRMAAHSFYDPGVDAAPMWAGVYTNMEIIDHLWGRVFAEIDMLERLHEVKAPVWIGLGRYDYLVSPVSLWDGIEERCSHVKVTVFEHSGHNPMWEEPEVFDRMLTEWVDGKE
>NC_016935.1|WP_014371069.1|5541635_5543024_-|MATE-family-efflux-transporter
MNTESLPTWKKLSLFAVTWPIFVDSVLRMMLGTADVYMLSRISDGVTGAVGLANEIIVFCILMFGFVGIGTSVAVAQFLGAGRAREASRISALAITVNFIFGLIVSLTLVVFGEGIMRLMNLPPEQTAIAKQYLTIIGSFIWIEALSYAISSIIRSNGQTRDVMFVTLGVNLIHVAGNYLLIFGHFGFPELGVTGAAVSTAASRLIGLVVLIVILYRRIPYPIRLKDYITWNSTYLKQILSIGLPSAGEHLSWQSQHMMIVSFINIIGTAALSTHVYVMNVSNYFMALGMAIGMGTEIIIGHMIGAGETKAAYHKLLRSLRFCFLLTAAVVGFASLFREQLMGLFTTNADIIAMGSGILLLSVILEPGRTFNLVVINSLRAAGDARFPVMMGVLSMWGVAVPLAYLLGIKLGMGLLGVWIAFTADEWLRGLIMLLRWRSRAWESKALVQPAGTAPAAAGQGA
>NC_016935.1|WP_013918874.1|5541226_5541415_-|hypothetical-protein
MRIQVELSVAGQPVKTEELVIEETKLGELTDEEIEQAIEIKIRSWADRMISIAWEVVDEEGE
>NC_016935.1|WP_013918871.1|5539825_5540920_-|AI-2E-family-transporter
MWYRENFFKYTVGAILVLLVIFLLGKIGYFFAPFRQMFSALFFPLLISGFLFYLLRPFVDYLEGKRLPRTMAILFIFAILTMVMSTAGSYLSTTIQQQFADLATNLQESIQDATEKTDDLLQENNTFFSIHDIEQRVSATLRSLIEWAQNNVGGIVSAFASAATTLTLVPFILFYFLKDSTSFHTRVVRPFPDEYKSELSKMLLEMDFTISAYVKGQALVAAFVGVFIYLGYLLIGLDFAFILALFAMFTNVVPFLGPFIGAIPALFIALTVSPVMALKAALVTLVVQQIEGNVLQPKIMGDKLDIHPLTVILLVVAAGSISGFVGLLIAVPVYAVGKIILFKSYRIYKFHHANQLEKRERMLP
>NC_016935.1|WP_014371076.1|5551170_5553471_-|ATP-dependent-helicase
MHQRIDFFASKKEELGVSLNEVQKQAVRETEGPLLLLASPGSGKTTTIIMRIGYLIERMGVEPSRIKAVTFSRASAADMKERFARFFPGLEPVKFSTIHSLAFQVLREHFYKTRTPYHLIEGQVELEEETEGDGAQPADQLPLHKKFILRHLFKTIAGENITDEQMEELTTYISLVKNKMIPPERWDSVKTDVPQAHRVLIAYEEYKRAGSGKGLLVDFDDMLTIGNEILERDRELLRRYQRRYDYVLTDESQDTSLVQHAIIEKLVREHGNLCVVADDDQSIYSWRGADPSYLLNFKDAYPAALTLFMEQNYRSSRDIVDVANRFIKRNKNRYEKNMFTRNPRSAPAQIRSFADYKSQAKYLVEEIRGIAELGEVAVLYRNNSSSIALINEFDRAGIPFFMKDTDNRFFSHWVVEDVLNFMRMSFTDKRADLLETIHTKCAGYITKGQMTQLLGIGNQESVFDNLLKHVPLKEYQVKQIELLRDNFRRMHGMAPKDAIRHIRGKLGYEKALDRLCERLGFRKEHLLGILNTLEEIADTLATMEEFAARLKHLEGVLKSSKHKKGQNVVTFSTLHSAKGLEFERVYMIDLIDGIIPSSDDKQGAMAEEAALSMEEAVRLFYVGMTRAKRHLELLTYKMRDGEKVQESPFVTDVRQLLNPGKPAVRPEPGRPAAAVTSGRVPAAAQAGAGRAAASGKSASPARKKNPNAVRQAADLAAGRDVLHPVFGSGTIVKLAGERIHIRFGTTDKVLSVATCLEMGLLELEKS
>NC_016935.1|WP_014371077.1|5553617_5555072_-|amino-acid-permease
MNHARKRGSGAAAQITPQGKQAGAEAFRTEALPGPGKPIAAENGSNQGTHAAPGADGRPGEPVVDGRSGMRPSLGLPQIVALYLGSVIGSDILLIPGLAAEQAGPASILAWLAMSILVVPMAVTMGWLAARHPGPGGVSHFVRLAYGAPYGNLTGWFFLLSVPLGGPVLAVTGARYLAVLLHWNAEQVYLTAAVIVLLPLLLNVYGLHLAGRLQTVVVAVILGVLVLSVTAAVPHVDTARLTPFMPHGPLSVVQAAGLMFWCFIGWEAVTHLSGEFVDPRRNAVRGILWSAGIVALVYLAVAFTTVATGSYGGENSAASLSLMVQRSLGAAGGWAVVVAALFICLAAHNAYSSAASRTAYALAQEGAAPKWLGALHPRYGTPVGGLLFIAAGSMAALLLLYSEAVSLAELIALPNAAFIATYIGGCMAGVRLLRDGRWGRRCAGLSLAAVLALYPFLGWPALFPAGAAAILFLRQVRRRNANQV
>NC_016935.1|WP_014371078.1|5555218_5556634_+|PLP-dependent-aminotransferase-family-protein
MFDLSLTNQEELPLYRQLYEQLREGIRDGRIADGSRLPSLRSLRAQLNISKVTVETAYGMLVAEGYAVSRPRSGLYAVRPKGIPPRSSAADPAAPAVAPAPPAAALQEHRIDFRPSAVDPHSFPLRIWRRMLHQASETAAGQLGRYGDPQGEEGLRRVLADYLRTSRGVVCLPEQIVIGSGIGYSMGILARLFTAKSPIAVEAPGYAPVREQWRHCGYEVIPLPAGRQGWALDELGNTGAQAAYLTPSHHFPTGMVMPYAAREQLLSWAHSRDAYIIEDDYDGEFRYEGRPLPSLQSLDRDGRVIYIGTFSKVFSPALRMNYMVLPIRLASLLRSRPDLLHAPSRMEQWAMHAFIAEGHWYRHIRRMRRAYRRKHETLVRGIRSRWDGRIEITGHSAGLHLEITVHTPHPAGRLTALAAEQGADVYDLRESWLEPAPDGPPRLYLGFGGLTEAEIDQGLTRLERAWKSLWA
>NC_016935.1|WP_014371079.1|5556732_5556909_-|hypothetical-protein
MAAGSKNELVRKDAGASEDMRAFLQSTASSGGRGDQKPDHNRKPDEQNKLTDQHNLRK
>NC_016935.1|WP_014371080.1|5556980_5558075_-|DUF4163-domain-containing-protein
MTNIHAHRKIRKTAVSLALAAVLAAGGSLNPAGASAETHEAAARYAITPQPVTVDGSSAVIPVIYSEGSTYIGLRALTEHLGLAIDWDAGERAASVTGRGRTLKVYPDTGVYTLNVNRLYGELPILQDGSLYVPLRFLLERLGYGVSYDQASRTIEVETIQENPLQIVTVTTDGGHPLVDAQYPQIEGFADTAVMGKINETLKKENEARIAEGIRQLGEAEKWNSELKTDNPEIETPQSVYSASYVVTYNENGRLSLYSDYYFYGGGAHGSTVRQGYTFDLKTGELLTLQEAAGSKDYVGIINREVQKQIGDTGLYLIAPFESVEPDRDYFLTHEGLVIYFQQYEYTAYAEGMPEFIIPYASFK
>NC_016935.1|WP_014371081.1|5558200_5558506_-|hypothetical-protein
MMGILFEVVGVLQENKVGFLFKQHTPMIDNQVFSILRLPTGNVKTIHKSMLGHPVRNMKLESGRIQICHGYCQEAQIGTMQERIERILMPKPQAEPAGQAN
>NC_016935.1|WP_041618457.1|5558614_5559790_+|DUF4850-domain-containing-protein
MRFTAARLVTLCGPLSSSKHLESRSDHMPTSRLPSRPFRTAWALVCACTLLLASCEPGGGPSADPKAANPSAAASVEPARTPQAGQPAEAPVQLSTGGGSADAPPPSASPAAAPPSPASSQDNAPSPADANGQPSAASGSAAHNPAAASAPPVPEPPPPAAAGQRPPGKQPRTEKSGRAAFEPAGAAKFEVPVVCVQADYGADPEGITLCPPAPLSFKKYKLTAHEASRMAVYWMSTGYGRGISVLAPGSWAVHDAVMGANGSVSFMLQHPNDPEQRIVYSDSGACQGCVIANIGGFFPGMEAWAEQQGFPVEPVRDFARRIPIGLDLLSYSLKISKTGYEAHGVASKEQPFYQFRLLEVNVKNGSRPLATAALNFFADTERQRIPQPMSP
>NC_016935.1|WP_014371083.1|5559926_5560625_+|hypothetical-protein
MLLDAIKDKVRQESYEDLKLPLDELERLTAFRPLVIQTPKEPAYVLFQAHPESYTAPVQKDGVRKVVDCSLLRPAGKLETDLMLEMYRHRIYTLYAFAFMFTYEDKGLILLWSQQLEQPPTFNRTQTNALLEEALGPEGDSSYFTLSRIFHPAQLIELTYENQTISTAVGGHSFVMIIPVEKKWTLSLRRSKKVPDDDFDILRRKLALYKEEAILLQNYFQRNGLWSEKASL
>NC_016935.1|WP_014371084.1|5560703_5562161_-|DUF5050-domain-containing-protein
MLRKLNLWTAAAAAGLLMLGPITNAEAAATEAVEVAFPAFPVTVNETALDGVHSLYPLLLHKGVTYFPMTWNYTSALGLSVSWNAEDGLSLTKTEGICGPVPQTLSAELKNSGRAADAVPVPFPVTVNGKAVDSPNETYPLLLYRNITYFPMTWRFTKEEFGWQAAWDPVSGYSIQSCPVEAAAGKRLQTALNLSNGGQLAADEKWIYKNPVRNSEGPHSLVRTELNGEHPLKLSDDLAMYINASGEWLYYIAYDQSGTIVKIRKDGTNRTILPATGVGELWADGEWLYYTKRTQQPESRENASSSPPGIYRMKTDGTGGVQLNPSGEVKSLYVYSDRIFYLKGEQGKEGLYSMKLDGSDDRKVQERVTDFIITEDWIYYVRDGKDIRKISLDGSIDIPLLEQEKPYMGRLSYKDGWIYFAAGATGIHGSLPLERVRLDGTGRETVFEARPTAIYWAGEAMYFAQWSLGSHVLYEHQLKEPAPKP
>NC_016935.1|WP_014371085.1|5562184_5563057_-|DUF4362-domain-containing-protein
MNRLVACFAGAAILLWGCESSEMPGKTKNVSAEVTNQHGNVENLTALDQYVQHSLEGQRGAVRIVHMTIEGDPIYNDLSFSGAGHKLRIDTTQDKFGSPKITDLTCRSMEKVESSVSMKYVLRGCSGEADERTVLHIAFDLAKQDRFEFALRYGPSAFDLQNEISTIDSRLSRDLINGSVHVAQGFEIPFEAKQRIYRALVLANYLGTKELSEGCEAAADETSAGSSSEQRNFSLKVLINGGSREFRWANCGNDSSGNTLGLTTVAEEIIREAEQTEAFRSLPPVQGARL

Crispr_ID: NC_016935_12

• CRISPR_ID: NC_016935_12
• CRISPR_location: 5860155-5860228
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_016935_12

Consensus_repeat	Method
TAGCGGAACTGAGATACGCTATG	CRISPRCasFinder

spacers of NC_016935_12

>12.1|5860178|28|NC_016935|CRISPRCasFinder
TTCCGTTTCAACAGGGCTGCTGCGGAAT

CRISPR arrays and Neighbor proteins around NC_016935_12

CRISPR arrays

The CRISPR arrays of NC_016935_12

>merge|NC_016935|12|5860155-5860228|CRISPRCasFinder
TAGCGGAACTGAGATACGCTATGTTCCGTTTCAACAGGGCTGCTGCGGAATTAGCGGAACTGAGGTACGCTATG

>NC_016935|12|8|5860155-5860228|CRISPRCasFinder
TAGCGGAACTGAGATACGCTATG	TTCCGTTTCAACAGGGCTGCTGCGGAAT
TAGCGGAACTGAGGTACGCTATG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016935.1|WP_014371271.1|5863190_5864354_-|hypothetical-protein	unknown	unknown	gnl|CDD|227511
NC_016935.1|WP_014371266.1|5847546_5847825_-|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_014371270.1|5857404_5858562_-|phytase	unknown	unknown	gnl|CDD|280491
NC_016935.1|WP_013919184.1|5861950_5862610_-|zinc-dependent-phospholipase-C-family-protein	unknown	unknown	unknown
NC_016935.1|WP_013919192.1|5870577_5871186_+|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_014371267.1|5852317_5853289_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|223674
NC_016935.1|WP_013919183.1|5861250_5861976_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|226425
NC_016935.1|WP_013919179.1|5856126_5857143_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|223521
NC_016935.1|WP_187297969.1|5855108_5856104_-|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|236898
NC_016935.1|WP_013919174.1|5850851_5851091_-|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|197775
NC_016935.1|WP_013919173.1|5850028_5850679_-|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_013919175.1|5851434_5852313_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|224094
NC_016935.1|WP_013919181.1|5858746_5859535_-|delta-lactam-biosynthetic-de-N-acetylase	unknown	unknown	gnl|CDD|131930
NC_016935.1|WP_081484344.1|5866304_5867426_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|226361
NC_016935.1|WP_013919189.1|5864976_5866101_+|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl|CDD|223715
NC_016935.1|WP_013919188.1|5864775_5864913_+|sporulation-histidine-kinase-inhibitor-Sda	unknown	unknown	gnl|CDD|370219
NC_016935.1|WP_014371268.1|5853334_5854987_-|peptide-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|173879
NC_016935.1|WP_013919186.1|5862879_5863038_+|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_013919182.1|5860775_5861036_-|YqkE-family-protein	unknown	unknown	gnl|CDD|315655
NC_016935.1|WP_014371276.1|5869285_5870347_-|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|270265

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016935.1|WP_014371271.1|5863190_5864354_-|hypothetical-protein	gnl|CDD|227511	COG5184, ATS1, Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton].	1.00359e-24
NC_016935.1|WP_014371270.1|5857404_5858562_-|phytase	gnl|CDD|280491	pfam02333, Phytase, Phytase. Phytase is a secreted enzyme which hydrolyzes phytate to release inorganic phosphate. This family appears to represent a novel enzyme that shows phytase activity and has been shown to have a six- bladed propeller folding architecture.	0
NC_016935.1|WP_013919189.1|5864976_5866101_+|HAMP-domain-containing-histidine-kinase	gnl|CDD|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	9.14435e-43
NC_016935.1|WP_014371267.1|5852317_5853289_-|ABC-transporter-permease	gnl|CDD|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	5.21611e-126
NC_016935.1|WP_013919183.1|5861250_5861976_+|AAA-family-ATPase	gnl|CDD|226425	COG3910, COG3910, Predicted ATPase [General function prediction only].	2.03709e-97
NC_016935.1|WP_013919179.1|5856126_5857143_-|ABC-transporter-ATP-binding-protein	gnl|CDD|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	6.77073e-161
NC_016935.1|WP_187297969.1|5855108_5856104_-|ATP-binding-cassette-domain-containing-protein	gnl|CDD|236898	PRK11308, dppF, dipeptide transporter ATP-binding subunit; Provisional.	2.17782e-144
NC_016935.1|WP_013919174.1|5850851_5851091_-|helix-turn-helix-transcriptional-regulator	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	5.51806e-05
NC_016935.1|WP_013919175.1|5851434_5852313_-|ABC-transporter-permease	gnl|CDD|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	8.40371e-111
NC_016935.1|WP_013919181.1|5858746_5859535_-|delta-lactam-biosynthetic-de-N-acetylase	gnl|CDD|131930	TIGR02884, spore_pdaA, delta-lactam-biosynthetic de-N-acetylase. Muramic delta-lactam is an unusual constituent of peptidoglycan, found only in bacterial spores in the peptidoglycan wall, or spore cortex. The proteins in this family are PdaA (yfjS), a member of a larger family of polysaccharide deacetylases, and are specificially involved in delta-lactam biosynthesis. PdaA acts immediately after CwlD, an N-acetylmuramoyl-L-alanine amidase and performs a de-N-acetylation. PdaA may also perform the following transpeptidation for lactam ring formation, as heterologous expression in E. coli of CwlD and PdaA together is sufficient for delta-lactam production. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Sporulation and germination].	4.16295e-121
NC_016935.1|WP_081484344.1|5866304_5867426_-|ABC-transporter-ATP-binding-protein	gnl|CDD|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	6.07628e-133
NC_016935.1|WP_013919188.1|5864775_5864913_+|sporulation-histidine-kinase-inhibitor-Sda	gnl|CDD|370219	pfam08970, Sda, Sporulation inhibitor A. Members of this protein family contain two antiparallel alpha helices that are linked by a highly structured inter-helix loop to form a helical hairpin; the structure is stabilized by numerous hydrophobic and electrostatic interactions. These sporulation inhibitors are antikinases that bind to the histidine kinase KinA phosphotransfer domain and act as a molecular barricade that inhibit productive interaction between the ATP binding site and the phosphorylatable KinA His residue. This results in the inhibition of sporulation (by preventing phosphorylation of spo0A).	7.07537e-07
NC_016935.1|WP_014371268.1|5853334_5854987_-|peptide-ABC-transporter-substrate-binding-protein	gnl|CDD|173879	cd08514, PBP2_AppA_like, The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold. This family represents the substrate-binding domain of the oligopeptide-binding protein, AppA, from Bacillus subtilis and its closest homologs from other bacteria and archaea. Bacillus subtilis has three ABC-type peptide transport systems, a dipeptide-binding protein (DppA) and two oligopeptide-binding proteins (OppA and AppA) with overlapping specificity. The dipeptide (DppA) and oligopeptide (OppA) binding proteins differ in several ways. The DppA binds dipeptides and some tripeptides and also is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	0
NC_016935.1|WP_014371276.1|5869285_5870347_-|ABC-transporter-substrate-binding-protein	gnl|CDD|270265	cd13547, PBP2_Fbp_like_2, Substrate binding domain of an uncharacterized ferric iron transporter, a member of the type 2 periplasmic binding fold superfamily. The periplasmic iron binding protein plays an essential role in the iron uptake pathway of Gram-negative pathogenic bacteria from the Pasteurellaceae and Neisseriaceae families and is critical for survival of these pathogens within the host. This periplasmic domain (Fbp) has high affinity for ferric iron and serves as the primary receptor for transport. After binding iron with high affinity, Fbp interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The ferric iron-binding proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	4.49466e-106
NC_016935.1|WP_013919182.1|5860775_5861036_-|YqkE-family-protein	gnl|CDD|315655	pfam13025, DUF3886, Protein of unknown function (DUF3886). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length. There are two completely conserved L residues that may be functionally important.	7.31607e-09

Protein sequences

>NC_016935.1|WP_013919181.1|5858746_5859535_-|delta-lactam-biosynthetic-de-N-acetylase
MRQKAKFAMRVTAVLLTGLLLTSGQPASADGGYHFGFKRSTKGQQPSIDQEGFKPLLQKYDAVFTGDPSQKELYLTFDNGYENGFTAGVLDTLKEKGVPAIFFVTGHYIESHPELLKRMTAEGHLIGNHSWHHPDMSQISTERMKEELLRVKDAVAELTGQKEMRYLRTPRGIFTERSLSVSRELGMTNVFWSVAYKDWDTTDQKGPQYAYDKVMAQLHPGAVILLHSVSKDNAQALGRIIDEARRQGYEFKSLDQMKVHTP
>NC_016935.1|WP_014371270.1|5857404_5858562_-|phytase
MKALKSRILTAAVLSLVLPAAAGLAGVPSVAEASALQSARVLPSAETDAVASGSDAADDPSIWVHPSDPAKSMIIATNKDGGILVYDLNGRQKYSYETGRMNNIDVRYGFKLAGQTVDIAAATNRTTNSIDIFAIDKSTGALRAVSGTPIVSSMSEVYGFSLYHSLKTGKYYALVLGKEGEFEQYELFDNGKGAIDGKKVREFKLATQSEGIVADDEYGRLYIAEEDAGVWLYGAEPGDGDVRETVAAVDGVKLTADVEGLTLYYAEDGEGYLIASSQGSSSYAVFDREDGEYEGSFVIADAPGIDGTSETDGIDVLGFGLGSQYPKGLFIAQDDENLQDGAVINQNFKIVKWDAISDAFEDVFGDDLDVDNDIDPRKLEYREED
>NC_016935.1|WP_013919179.1|5856126_5857143_-|ABC-transporter-ATP-binding-protein
MIHYVSIVHSISEVFVLSESILEVESLTTVIRDKRREVTIVDGIDFRIGRGEVVALVGESGCGKSMTSLSIMGLLPRTGAIARGDVRFHGRSLVGLKKRQLSQIRGRHISMIFQEPMTSLNPVLTIGTQLTESIVRHLKTDKAAARASAEEWLRRVGFPEPARICREYPHRLSGGMRQRVMLAMAMACRPELLIADEPTTALDVTIQAQVLDLLRELLRESEMAVLFITHDLGVVAEMASRVIVMYAGQIVESADVRTLFTSPRHPYTQGLLQSTPRMHGGPERLVPIAGSVPPPGSHGPGCRFADRCPIVRPECRDAMPKLEGIGPSHEVRCIAATS
>NC_016935.1|WP_187297969.1|5855108_5856104_-|ATP-binding-cassette-domain-containing-protein
MSMSEPLLQVSNLKKSFPYGKGAGAGQVRAVDGVSFTVQEGETLGIVGESGCGKSTVGRLVLRLLDLTEGQIRFGGREIGCMSQRELRPLRRQMQCVFQDPYASLNPRLTVGQTVAEPLIVQDKLSRSAAMARAEQLLDLVGLGAGAASLYPHEFSGGQRQRIAIARAIALQPRLIVADEPVSALDVSIQAQIVNLMRDLQEQTKISYLFISHNLSVVSHISDRVAVMYLGRIVELASRDDLFLRPRHPYTKALLTSVPEPDVERPRERILLRGEVPSAANPPSGCPFHPRCPAAEVRCSIETPAFRETAPGHFAACHFAETIESAPLSVS
>NC_016935.1|WP_014371268.1|5853334_5854987_-|peptide-ABC-transporter-substrate-binding-protein
MKLRSSRPAAALSALLSAAVLLSACTSGENTTAPPAGEQTPPAAEAKKEKTDGGEIIWAYLSDPQGFSDLWATTTTSSEINDLVTSSLYHYSTKQDLDPDLAVGQPTFSEDKKEMTVKIRTDAKYTDGQPVTADDVVFTYNVALSPDYKGPRKGVFEQLAKVEKVDEATIKFTFKQPFASFIDLMAYNILPKHILGETPVKDMDKAPFIKQPVGSGPYKLEEWKQGQYLRLVRNENYYGGKPAVEKVTVKIIPDANSIMAQLQTGEVNASTVPADNLAVIEQYAKTSGKIKLQKGIKSSTYLYVAWNLTNPLFQDKKVRQALTMAIDRQGIVDGVQEGQGVIVHSQTPPTYWSYTENVPKFPFDAEKAKAMLAEAGWKDSDGDTILDKDGKKFEFEMQVNQGNKVREKAVTVIQQQLKKIGISVQPRVVEGSAFSKNFQSKQFESIFYGWNISGDPNPKGIWHSAEIEHGLNNVTYKNPEVDKLIDEDLQTFDTNKRKELLGKIDALIAEDQPYTFLYSPTTTVAYPANLEGFNPARDSLREVEKWYFTK
>NC_016935.1|WP_014371267.1|5852317_5853289_-|ABC-transporter-permease
MSRYVLQRLLNAIPILIGITIISFAIIHMAPGSPLSAFMEDPTIKTADKENMVRTYGLDQPLYVQYWKWVSGMVTGDFGTSFLKNQPVSDLILDRLPNTLLLTVTSMAISLLIALPLGILCALRVDSRLDRFVSSMTFVGMSVPAFWLGLMLIMFFSVKLGVLPSGGLQTVGGSFSLTDRLQHLVLPLFTIVCGEVAVWTRYVRSSMLEVINQDYMRTGQAKGLRDARVLGVHGLRNALIPLATLFGLSLPGLFAGTLIVETIFSIPGMGRLFTEAAFQRDYPVIFAITTISAFLYVFGSILADISYALLDPRVSYTTKEAKG
>NC_016935.1|WP_013919175.1|5851434_5852313_-|ABC-transporter-permease
MEAAIGAVPPGAAPSKKENRAWARFKRNKMAMASLVIMIILVLLALLAPVIAPHDPAEQDLLNRLKPPSAAHWFGTDDLGRDLFSRVLYGARVSLSVGIVSVVLNVIIGVTVGSLAGYYGGRVDAVLMRFVDMMLAFPSLFVMIAVVTLLRPSLFNIILVFVVFGWMSKARLLRGQILTVKNREFVEAARTIGMSDARIIFVHILPNSLAPVIISATLQMGTMILTESTLSYLGLGIQPPAASWGNLLQSAQNLTILMKAPWLPFIPGFMIFLTIMSFNFIGDGLRSALDAK
>NC_016935.1|WP_013919174.1|5850851_5851091_-|helix-turn-helix-transcriptional-regulator
MKLEARACLLQERLNERGLKVEELAGKLFYKPEKLYDYISMTRIMPLQVAVSIADTLGCEVRSLYEWVPVEGIPGKEGS
>NC_016935.1|WP_013919173.1|5850028_5850679_-|hypothetical-protein
MDNLPLAAFFFVTWIGIFMLALAFFRIKFHTYVKPMLITVGLMTPLSWALIQLMEIHEYFHMLNAPVEIGVATLCMHRLFKLSRTDSFMMVTLSYGIAVFMENVTSMIVNDYQMDRASIALASGIMHQEWFFAFLIFLMSYAMLSLRLGFTVVRRHVQPAMSKRFRIVLVLTFCSVWFSNIIVHFVGELLLLSTYLMFFIFGYLCIRLYRQELEED
>NC_016935.1|WP_014371266.1|5847546_5847825_-|hypothetical-protein
MGSEIAGSELQVSKWRFADAKVRSCRSRDAGSYRLGSDLPEHVRTLEDQGNGGPAAARMSDIYPLIVGISTLKIWGNYPIIEERSMRYGIPK
>NC_016935.1|WP_013919182.1|5860775_5861036_-|YqkE-family-protein
MVKKRGPVAAPKAAAEDKPATLKDLLNPEVLQKLKAQSESMKAEAEQRREEERRRAEETRRAEQKRLDNDFGHLLEKSDPNWRKYK
>NC_016935.1|WP_013919183.1|5861250_5861976_+|AAA-family-ATPase
MYLRELTLLRSRIPDDSVYPFNIPAVRHLDTLNFSGSITFFVGENGSGKSTLLEAIAYQCGFHTAGGGRNNTYEVDAAHSALGDYLRLSWMPKVTSGFFLRAETFYQFASYLDRNPESLHSYGGKSLHRQSHGESFLSLFVHRFGGKALYLLDEPEAALSPARQLSLLRIMKNLEDRAQFIVATHSPILLGYPGAAILNFDDVPVAPIRYEDTAHYVLTRQFLENRDRLLHELFKDDEDEE
>NC_016935.1|WP_013919184.1|5861950_5862610_-|zinc-dependent-phospholipase-C-family-protein
MPSRIMHLIIADALAKEVGAQAPGALLLGALAPDAAKADEAASEALHFASRSYIAYGDFLHRYGERMPDPFLLGYLSHLVGDDIWSIFVHASGLRDRVREEPRLAKVYYRDFLLCNAKLLEAYPKEELYAALLEAEIPSGWSGREGGLGPLLAEQKRRALLDFDYPAAHLTEELQLITLGDVHLGMDRCIQRTLDLYRPWLQSDPDAREDAFILHPHHL
>NC_016935.1|WP_013919186.1|5862879_5863038_+|hypothetical-protein
MIYHVLHSSTRELRILTPAEVLDMDTDAAGRIVIHGADGEFYYLLADESLTA
>NC_016935.1|WP_014371271.1|5863190_5864354_-|hypothetical-protein
MNYRKKSFSRTRLLGTSLLLSSLLLTAAGPVSAQDAAGPAAEGAHFFFSSAARHNVVMDDAGSLWYWGNKAQVTGGETIVHDNKPERIMSLAGAKQVAASVKRNLILKEDGTVWTWSCDWVIDPMTGEGGSKFSVPQQITGLSNIVKVSAGMSLYAALDKEGRVWMWIDPPYGTGEASPVSDLSDAVDISAGIGSLVIVKKDGTVWQWKQFEGFNLNTDKKFTKVEGLEGIVKLSQGEEAGHFMAIDKHGDVWGWGNNVVNQIGPQTEPVSDRDKPVIRKPVKIQGLSHVTEVITTSFSTLALSEDGSLYFWGLNPAWASGSKETMKWDTPQPWAGLRDIIAVEAGESHYLALRKDGTLWAWGENALGQLGDATFRKSLTPVQVKLP
>NC_016935.1|WP_013919188.1|5864775_5864913_+|sporulation-histidine-kinase-inhibitor-Sda
MNHSLEKLSDEDLLEAYLLALDLKLEPSFIRLLRDEIDRRQLHMD
>NC_016935.1|WP_013919189.1|5864976_5866101_+|HAMP-domain-containing-histidine-kinase
MNPIITQWVSGVEERFPGRYDSAELLRTAESYFHLVNDWHIPLELHPLFPVIPALTRYHVSMSTPPTHLLESSHLWRSILLASSTELYTEGLVSGDELISDMPRIHGRIDEIQYVISSGFWEHSQRQLDSAMTQMHKERLQMAGKLAASMAHEIRNPLTTISGFLKLLTSKIPAESAGAVKHYVSIIQEEFNTIQMHINNFLNFSKNKEQEPFREVGMEELILGIVNLVAPRLSSEGIELLSGVEGPNIRLRVQQVGMQQVLINLINNSIDAVQHMEPSEPKMISIHGFEDRDHTYIRVTDNGPGIPPDVKDKLFSPFVTSKTTGTGLGLAICKQLVEQHAGVLSFDSRPGETSFTVKLRKTGVGAVPVNSASV
>NC_016935.1|WP_081484344.1|5866304_5867426_-|ABC-transporter-ATP-binding-protein
MSMGNTIKAARTETGGAGRQPQAAPLIELRGASKTFGGDPALHPVDLSLALGEFTAVLGPSGCGKTTLLRLLAGFEAPSSGEIRMNGTLVAGGGVLVPPEQRGLGMVFQHFALWPHMTVAEHIRFPLRHNRHQEPAASREERVREVMEALGLSALADRRPHQLSGGQKQRVALGRAIAPRPRLLLMDEPLSALDALLRVEMRREIQEAHRLSGAAVVYVTHDQGEALAMADRVIVMNQGRIEQAGPPEEVYMRPETPFTARFVSKANLVEGSWEEGGFRPRAGGSAELWACEEPPPAFRQHGVMPVRPGELMLGFAGGGGIPGRVTAAQFQGSEYHYYVDTGTEVWEIHATDRFALGSHVTVYWGGGNSFPQA
>NC_016935.1|WP_014371276.1|5869285_5870347_-|ABC-transporter-substrate-binding-protein
MQKKRKTIGLIGLLTVLALTGCGTKAQPGASAPAAGAGTQESAAASGTLSGTLNFYTSQPEEDVTKLVAAFQGKYPDVRVAPFRSGTEEVIAKVQAEKQAGKVQADLLLLADSVTFESLKRQDLLAAYQSPEAAKLPPGYADGDGAYTGTKIIATVLAVHTGKVKTVPASWKALAAPENKNAAVMPSPLYSGAAAYNIGVFTRTEGFGWDYLRSLKEGGMTVVKGNGAVLKSVASGEKSMAMVVDYLVAREKAKGSPVDLVYPSEGVPVITEPIAIVKNSPNRKLAEAFVDFVLSEEGQTLASKLGYTPLREGVPAPQGLKALKDIKVLSASPAELVEAREADKKQFTEVFGQ
>NC_016935.1|WP_013919192.1|5870577_5871186_+|hypothetical-protein
MERLLALDAKVFPPSHRIDAATTERRLRVNPRTDIAVWDGEELMGYVSLYPIPHAIYREIRSGSFDEQRVERHTLPYRRIGPYDAYLCGIAIDKMRYPRLRAAYLFDLLSKHLTRLRRQGFFIRRIIAHAVSAAGRRTLERMGFHEGQPGIYLYHCLRQGLLFIRPRTSFPAILSIAPGQGQCMFSAAPSAYNGESVWDTDT

Crispr_ID: NC_016935_13

• CRISPR_ID: NC_016935_13
• CRISPR_location: 6674011-6674199
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 3 spacers

Consensus repeat of NC_016935_13

Consensus_repeat	Method
ATAGCGCATCTGAGTTCCGTTATTT	CRISPRCasFinder

spacers of NC_016935_13

>13.1|6674036|26|NC_016935|CRISPRCasFinder
GCCTGAAAAAGAAGCCCTCGCAGCAA
>13.2|6674087|37|NC_016935|CRISPRCasFinder
CGCCTTTTATGCCAGCAGAACCCCCTCTAGGCGTACA
>13.3|6674149|26|NC_016935|CRISPRCasFinder
TCATTTTCACCTTGCATTGGGCCCCG

CRISPR arrays and Neighbor proteins around NC_016935_13

CRISPR arrays

The CRISPR arrays of NC_016935_13

>merge|NC_016935|13|6674011-6674199|CRISPRCasFinder
ATAACGGAACTCAGATGTCTTATTTGCCTGAAAAAGAAGCCCTCGCAGCAAATAGCGGAACTACGATTCTTTATTCCGCCTTTTATGCCAGCAGAACCCCCTCTAGGCGTACAATAGCGCATCTGAGTTCCGTTATTTTCATTTTCACCTTGCATTGGGCCCCGATAACGCATCTGAGTTCCGTTATTT

>NC_016935|13|9|6674011-6674199|CRISPRCasFinder
ATAACGGAACTCAGATGTCTTATTT	GCCTGAAAAAGAAGCCCTCGCAGCAA
ATAGCGGAACTACGATTCTTTATTC	CGCCTTTTATGCCAGCAGAACCCCCTCTAGGCGTACA
ATAGCGCATCTGAGTTCCGTTATTT	TCATTTTCACCTTGCATTGGGCCCCG
ATAACGCATCTGAGTTCCGTTATTT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016935.1|WP_014371699.1|6662319_6662838_-|L,D-transpeptidase	unknown	unknown	gnl|CDD|341130
NC_016935.1|WP_014371713.1|6685384_6687133_+|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|182732
NC_016935.1|WP_014371710.1|6680947_6681427_+|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_014371708.1|6679717_6680236_-|DUF3231-family-protein	unknown	unknown	gnl|CDD|371599
NC_016935.1|WP_014371700.1|6663850_6664576_-|Crp/Fnr-family-transcriptional-regulator	unknown	unknown	gnl|CDD|223736
NC_016935.1|WP_014371704.1|6670321_6670900_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
NC_016935.1|WP_014371706.1|6675114_6677964_-|fibronectin-type-III-domain-containing-protein	unknown	unknown	gnl|CDD|227785
NC_016935.1|WP_013917891.1|6664865_6665252_+|response-regulator	unknown	unknown	gnl|CDD|381097
NC_016935.1|WP_014371707.1|6678505_6679537_-|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl|CDD|187575
NC_016935.1|WP_014371702.1|6666428_6668888_+|TPM-domain-containing-protein	unknown	unknown	gnl|CDD|377378
NC_016935.1|WP_013917897.1|6670899_6671682_-|DUF3891-family-protein	unknown	unknown	gnl|CDD|379025
NC_016935.1|WP_014652320.1|6671789_6672077_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
NC_016935.1|WP_014369723.1|6689579_6690596_+|transposase	unknown	unknown	unknown
NC_016935.1|WP_014371709.1|6680382_6680946_+|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_013917885.1|6661262_6661427_+|DUF1328-domain-containing-protein	unknown	unknown	gnl|CDD|227774
NC_016935.1|WP_014371712.1|6682821_6684810_+|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl|CDD|223910
NC_016935.1|WP_014371714.1|6687171_6689292_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224055
NC_016935.1|WP_013917886.1|6661661_6661898_-|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_014371703.1|6669144_6669354_-|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_014371711.1|6681635_6682595_-|acetylxylan-esterase	unknown	unknown	gnl|CDD|368448

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016935.1|WP_014371699.1|6662319_6662838_-|L,D-transpeptidase	gnl|CDD|341130	cd16913, YkuD_like, L,D-transpeptidases/carboxypeptidases similar to Bacillus YkuD. Members of the YkuD-like family of proteins are found in a range of bacteria. The best studied member Bacillus YkuD has been shown to act as an L,D-transpeptidase that gives rise to an alternative pathway for peptidoglycan cross-linking. Another member Helicobacter pylori Csd6 functions as an L,D-carboxypeptidase and regulates helical cell shape and motility. The conserved region contains a conserved histidine and cysteine, with the cysteine thought to be an active site residue.	2.71471e-44
NC_016935.1|WP_014371713.1|6685384_6687133_+|ATP-binding-cassette-domain-containing-protein	gnl|CDD|182732	PRK10789, PRK10789, SmdA family multidrug ABC transporter permease/ATP-binding protein.	6.54674e-180
NC_016935.1|WP_014371708.1|6679717_6680236_-|DUF3231-family-protein	gnl|CDD|371599	pfam11553, DUF3231, Protein of unknown function (DUF3231). This bacterial family of proteins has no known function.	2.26273e-24
NC_016935.1|WP_014371700.1|6663850_6664576_-|Crp/Fnr-family-transcriptional-regulator	gnl|CDD|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	7.09287e-39
NC_016935.1|WP_014371704.1|6670321_6670900_-|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	6.09163e-12
NC_016935.1|WP_014371706.1|6675114_6677964_-|fibronectin-type-III-domain-containing-protein	gnl|CDD|227785	COG5498, ACF2, Predicted glycosyl hydrolase [Cell envelope biogenesis, outer membrane].	2.78721e-125
NC_016935.1|WP_013917891.1|6664865_6665252_+|response-regulator	gnl|CDD|381097	cd17542, REC_CheY, phosphoacceptor receiver (REC) domain of chemotaxis protein CheY. The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	8.81859e-38
NC_016935.1|WP_014371707.1|6678505_6679537_-|NAD-dependent-epimerase/dehydratase-family-protein	gnl|CDD|187575	cd05265, SDR_a1, atypical (a) SDRs, subgroup 1. Atypical SDRs in this subgroup are poorly defined and have been identified putatively as isoflavones reductase, sugar dehydratase, mRNA binding protein etc. Atypical SDRs are distinct from classical SDRs. Members of this subgroup retain the canonical active site triad (though not the upstream Asn found in most SDRs) but have an unusual putative glycine-rich NAD(P)-binding motif, GGXXXXG, in the usual location. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	4.05662e-69
NC_016935.1|WP_014371702.1|6666428_6668888_+|TPM-domain-containing-protein	gnl|CDD|377378	pfam04536, TPM_phosphatase, TPM domain. This family was first named TPM domain after its founding proteins: TLP18.3, Psb32 and MOLO-1. In Arabidopsis, this domain is called the thylakoid acid phosphatase -TAP - domain and has a Rossmann-like fold. In plants, the family resides in the thylakoid lumen attached to the outer membrane of the chloroplast/plastid. It is active in the photosystem II.	9.3079e-11
NC_016935.1|WP_013917897.1|6670899_6671682_-|DUF3891-family-protein	gnl|CDD|379025	pfam13030, DUF3891, Protein of unknown function (DUF3891). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and archaea. Proteins in this family are approximately 250 amino acids in length.	3.9217e-75
NC_016935.1|WP_014652320.1|6671789_6672077_-|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.18397e-07
NC_016935.1|WP_013917885.1|6661262_6661427_+|DUF1328-domain-containing-protein	gnl|CDD|227774	COG5487, COG5487, Small integral membrane protein [Function unknown].	0.00215829
NC_016935.1|WP_014371712.1|6682821_6684810_+|methyl-accepting-chemotaxis-protein	gnl|CDD|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	7.23236e-59
NC_016935.1|WP_014371714.1|6687171_6689292_+|ABC-transporter-ATP-binding-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	2.27995e-169
NC_016935.1|WP_014371711.1|6681635_6682595_-|acetylxylan-esterase	gnl|CDD|368448	pfam05448, AXE1, Acetyl xylan esterase (AXE1). This family consists of several bacterial acetyl xylan esterase proteins. Acetyl xylan esterases are enzymes that hydrolyze the ester linkages of the acetyl groups in position 2 and/or 3 of the xylose moieties of natural acetylated xylan from hardwood. These enzymes are one of the accessory enzymes which are part of the xylanolytic system, together with xylanases, beta-xylosidases, alpha-arabinofuranosidases and methylglucuronidases; these are all required for the complete hydrolysis of xylan.	4.43047e-169

Protein sequences

>NC_016935.1|WP_014652320.1|6671789_6672077_-|GNAT-family-N-acetyltransferase
MRYTGEVWEPRRIICGLIAEEEGRAVGFGSMVIKNRFWQESYVGRITALVVEERMRGRGIGRTLIEELSRDRGGERVQEGGARFGVSPGGSPPFL
>NC_016935.1|WP_013917897.1|6670899_6671682_-|DUF3891-family-protein
MIVRDTGDAWVLTAQHEHARLSGDAARRFRPFFEGDPHFEDLVTAVYQHDLGWVRLDETPVWNDRASAPYSFIDYPLLPKLTHYRLGLDQVEELNPYAALLCSMHYAAFVEGSTDEESSAFHRYETGRQERIRKELGIPGAKELQKPFSLLKLCDRISLYVTLNEPGAGKEQEYPPYRTGFGQSESFHPDGSGILAARWISKSEIEMAPNPFEHTFRTSVRQKRVPKALAGEIGLAEAYRRTEETEQEVVFHGRTGEEEA
>NC_016935.1|WP_014371704.1|6670321_6670900_-|GNAT-family-N-acetyltransferase
MASVRPLSPEDAEAFLKLRLEALREHPAAFSADEADWRSKSVEEAALLLSGARGSFVLGAFDAEGELVGMAGFQPNDKPKLSHKGILWGMYVTARVRRQGAGRALVEALLNRARLLPGIRRVNLGVIRTDGGACRLYASAGFQVYGTEPRSLHYDGTFYDEDLMYFEWEDGKTGRRGGCHDIGEEMGLGRPV
>NC_016935.1|WP_014371703.1|6669144_6669354_-|hypothetical-protein
MQTFLDDEGQLMQRTDKLMDVSLNVVGKATAHYHNIRRAVHRNSEQIDKSFRSIDQARTLIETARRSLR
>NC_016935.1|WP_014371702.1|6666428_6668888_+|TPM-domain-containing-protein
MNKLISLTLTLVFLLGSPVSAADVPPKSGAVQDTAGMLSGRSLSALERAAEGPYSFHVLTVESLQGRPADAYATSVYRAWNLQREDVLVLLSESDRRIEVQFENPGLQRRLDALPADYDRDGLRESSIDEWVGAHFLPHAQQGDFAAGLLELMQSGQQLASSVPATGTPSGAGTAAGVSPGFGGLLPLLAGGLVLLLAGWFVMALLKRRRLSALQEELTGSAKTLIVEISRTQEALTPIRELYPGERTSEAADRLEEELTALSAEVQGRLERISGYAVPLLGAGSAARDLEAVRAELAAFRTRFEEARREVDHLAGLDRSISEEIGKLQSKAAAAEARVAELSARHGLPMDELKADLSGMREELERSSALQVSDLLAAEQEVLPLQEKLAAVRSELDKLPGYLEELERLPSRIETLRAETGRELAASGLRPAEAWDPYAPLAEAQRSGEAMRRALERGSLEEAGSASAAIAGLLERARGEAAGRAALRDAVTGRLQQIEAALTAYAAADRTYPEERTKAQAEFAEKHWGPAEESYRSLKTAAAGLRQGLEAARPLASPQTQAYTEAGRLTEELLLRLKEAEALYAAVLGVYTGPSRRLQELRDEEAQAWSLFRSGKSLAEARSLPLHTQGNRQLALLERELHGQKEHIHAALASPPYDLEELAALIARLSSDARAYQAGISRMAEEKEQAERMLREVHARYQAVALRAGSRLTHTGYTRSYAANMSEIQNLFVLGLYGDALQRLAAADQAVSQLDMAYHALLQEEQRQIPDAPEVLRVRRRLEQRRTFLRRRQLGRRRWWRTLLRRGRLVAGAGRACPP
>NC_016935.1|WP_013917891.1|6664865_6665252_+|response-regulator
MNPKEVKIMLCDDSLLVRKKLKSALEEQGYTGILEASDGLEAVALCREQKPDLVLMDIVMPRKDGIEALKEIKEFDKSIHVVMVSSVGTQGNLIKALKAGADNFMQKPVTIEALNELIHKMAQDRREA
>NC_016935.1|WP_014371700.1|6663850_6664576_-|Crp/Fnr-family-transcriptional-regulator
MQTATKQTMTERPYHIPQFLSSANMERLEKVMVLQRASEGSHLFWEGDTADKLYFVKKGAVKLMKSTEDGRSIILQIAQAGDLFGEFGDPGAMSFGYDAVVLAEATLGVIALSDLENLMRSSGDFAVEFVKWQSLMQRAAQTKLRDLLLYGKSGALAATLIRLASSCGIRTERGVRISMRLTHTDLAHMIGSTRESVNRLISEYRAEGALDFQKGYITVKDEAFFKDMVGGTDIPLELCRI
>NC_016935.1|WP_014371699.1|6662319_6662838_-|L,D-transpeptidase
MGMLAVCLLSAVWGGSASASPVSAAAPAPGPAQKNDAPPPGLQEEGVYVVISKKTNRLTVYMNGAPYRTFPVATGRRSWLTPAGTFHIITKIKKPWYIRKQIPGGDPANPLGSRWMGLSVPGTGGYTYGIHGTNRPYSIGHSASSGCIRMHNRDIEWLYRHLPLGTVVIVKE
>NC_016935.1|WP_013917886.1|6661661_6661898_-|hypothetical-protein
MATPRIPQPPDVVTLSVVRNPLTGRRIITGSSVIGSAAPCAALIAPGSRLAPALRCLVRSGFRLIARTQGIWVFRRIR
>NC_016935.1|WP_013917885.1|6661262_6661427_+|DUF1328-domain-containing-protein
MITWSFLFLLVAVAAGIFGFLGIAGTAAGIAKMLFIAFLILFVASFFTGRKGRT
>NC_016935.1|WP_014371706.1|6675114_6677964_-|fibronectin-type-III-domain-containing-protein
MKKKMLSLALATVLAAGLLPGTGQAFTGEVPLGAGSYSTVLPAGAADVQAQIYKTGNVTGKMPTNDWWSSLAWVQHSEAQYPHPLAVKNQSDGFRIYNPSGRITANSSCVCGWINDIHDFTVGHTGSGTFTDAKVDGFSDWFVKAQYQNGASSMNVSYGHGSPYVYFNFGGGNPQLKFYTPPTVWSGSAGSSVLGITIEGAHYGLFGPTGSTWSGIGTNALTNALNGKTYFSIAAQPDNTAATLNKFKQYAYSHVTDTKISYGYNAAAGEVTTTFNYTTSAKEGTQTGTIFALYPHQWKNSSQALLPYTYNSVRGTMKTGEGASFTTRMKFTGVLPALPDKGTYNKTTLGGYINEEEALAYTGGTDTYWLGKRLGKLATLAPIADQVGDTTASAKFRSEIKSRLQDWFKASDASGHLKGSNVFYYNNNWGTLIGYPASFGSDGELNDHHFHYGYYIKAAAEIARTDKAWAQSWGPMVELLVRDIANWNRSDTMFPFLRNFDPYAGHSWASGHARFGDGNNNESSSEAMNAWAGLILWGEATGNTTIRDLGVYLYTTEMNAINDYWFDVQDNTHPAAYTPSVVTMIWGGKGANATWFTANPEQVHGINWLPITAGHLYLTHYPSYAAKNYNALVSENGGTNWDIWRDLIWMYRAISSPADAKNQFAAGVGSMATGGAEGSGGPETGNSKANAYHWIYNLDAMGNADPAITANSPTAAVFNKGGVKTYVAYNFSNSAKTVTFSDGTSVSVPANSFNTGNGGGTGGGDTVAPSAPSGLVSTGKTSSSVSLSWNASTDNVGVTGYTVSYGGNSLNVTGTTATVSGLAAGTAYTFTVTAKDAAGNVSAASSAVTVTTDSAGGGGVITTPDYTASVTKTSATQAKIAFTPTVNALYVDVHYTVNGGPQLNYRMTKNGSTWEQPVDGLSAGSVLKYWFTYEKSGPQYDSPQYTYTH
>NC_016935.1|WP_014371707.1|6678505_6679537_-|NAD-dependent-epimerase/dehydratase-family-protein
MKLLVLGGTRFVGYEVVLSALSRGHEVTTFNRGQTAKGVHSGVKELYGDRDGGLDVLRGGTWDAVIDTCGYLPRLVRASGQELADRVGVYTFISSISVYKDLSVPLNHEHSDVRELEDESIEDIPNHYGALKARCEQILESFMPGRVLTVRPGLIVGPRDLSDRFTYWPVRISRGGEILCPGQGDSEVQFIDVRDLAEWTVAMTEARRTGVYNAAGPGVRLTMRELLERAREALGSSAVFTWCGESFLAEQGVRGWSDMPVWLPAEGELSEFRGMLQADYSKAVQAGLTFRPVEETVRDTVRYHGHRGEGDAWKAGLSAARERELLALWHGGKSGERRDGGHG
>NC_016935.1|WP_014371708.1|6679717_6680236_-|DUF3231-family-protein
MGILSGNPKHEPMHYGEIHQVWQFSMAAKGCISATELYRNHAGDRTLKSILGDILDQARLESKECDELLMHNGIMPAPALPARPEVELESIPAGARFGDPEIAAMIAADQSMGLVACSQVMGMSIREDIGALFAKYHATKAAISTRILRMNKEKGWLIPPPLQVKSEDLVKV
>NC_016935.1|WP_014371709.1|6680382_6680946_+|hypothetical-protein
MSRHPRLGGSLQIRTPIIRPAGERPMSLDHAFLLAIAVSAVAVLFFGIPRSQIREALISFTCFQALTWPVGFAITGLGWITYPVRIFPLATDLGFLFDYLFCPAVFTLFQVRYPQDRPLMVQGAYYAVYAVGVALLQSWVADHTGLIDFKRWTAYNSILLYLAEYWVARRYVIWFLRRWAPSLRGER
>NC_016935.1|WP_014371710.1|6680947_6681427_+|hypothetical-protein
MYTTELIILGAANLGALLSLFLLPRGKVLQYHLVFLVVSLPTWVIGLMVVEWGLLAYPVRELAAINRTSFCFEYFLLPIVAVHYNAWYPENKRLGGRALYLLLYCSALTVPEILIERYTDLLSYLHWSWYITFVSEGFIFLYSRAVLLWFFRPSSHRMS
>NC_016935.1|WP_014371711.1|6681635_6682595_-|acetylxylan-esterase
MPLLDMPLGQLQTYQGRNPRPDDFDAYWEKALEEMRNVDPQVELVPSSFTVPFAECYDLYFTGVRGARIHAKYIRPKGVDTPHPAVLHFHGYTGSSGDWQDKLSYAALGFAYASLDVRGQGGLSEDTGGVKGTTHNGHFIRGLDDEPQNLLFRHIFLDTAQLASIVMGFPEVDAGRVGATGWSQGGALTMACAALEPRIKKAAPVYPFLSDYRRVWEMDLAKDAYAELRTYFRHFDPQHQREEEIFTKLGYIDIQHLAPRIKADTLAGVGLMDPICPPSTQFAAFNKMTAPLKLEIFPDFGHEGLPGMNDKIYQFLKEL
>NC_016935.1|WP_014371712.1|6682821_6684810_+|methyl-accepting-chemotaxis-protein
MNKWFGKSIRAKIIALLLSVTMIPLLIACSLLMAISTGAMETSTKVNQTALAQLSAASIDTWLKGKITSAQRVIDAHPEFKQGNPAQIVPILKVLTEADPDVQAFNFVTSTGASHRIDGSVVDVSKFDNFKAAQSTMKTAVSDIRKSAATGENVIIIDVPFKKDNGEFAGLLQMLLSPADLISMVSSIKEGSGYGYLLSSTGTYLIHKEVERVGKPAGELLGDAAAAFENSVLKYTNGTLDYTEADGASYAAAYDAVASTGWKMVIIAPEKEVYAEVNRTRITTIAIIVISLIVVTGIALVVARIISTPLLRISSLMKEVAQGRLVDRLEVRGEDEIQTLKAHINHMLDSFCELIGKISESSEIVAASSEELTATSLQTAAATEQVNRSVSFIATSSEAQYESASQTSMTMTEMAVGITRIAESASGVSEATNEVVSDVTSGHAEVQAAIRQMTAVGGTVRQTANAVQSLEQQSHTIGEIIDVIRGIAQQTNLLALNASIEAARAGEHGKGFAVVATEVKKLAEQTRTEAERITVIVSSILDNTRTVASSVNEGVEMMNEGVGQVSKVGEIFEHVLASVRSVSDQIQEVSAASEELSAGTEEVAASMSEMLHVTKEAAEQLAQVSRAASEQKQSMDEVSNSSQSLSEMAMELREMVSRFSTK
>NC_016935.1|WP_014371713.1|6685384_6687133_+|ATP-binding-cassette-domain-containing-protein
MLTVLYKLRWFFRQHWRRYTAAILLLTVAGVIDVIPPKLIGYSIDGIHQGTLGGTHFYGILALWAAITVIGYAINYVWMCQLFGGAFVLERTLRTSLMKHLLRMTPTFYERNRTGDLMARATNDLRAVSTTAGFGILTLIDSSIFMLTILITMAGFISWKLTLASLLPLPVMALLIQQFGGRIHKRFTEAQEAFGQMNDSVLETIGGVRVIRAFVQEQASREQFGEMTRHVFHKNAEVARIDALFEPTVKILVGLSYLIGLCYGAYLVFHGELTLGELVSFNVFLGMLIWPMFAIGELINIMQRGSASLDRVNETLAYEPDVPGPAAPAAVARPETLAWNGLTFRYPSSPIDNLVDITFELQRGQTLGIVGRTGSGKTTLLKQLLREYPSGSGSLTVSGTPIEEIDLDVLHGWIGYVPQQPILFSRTIRENILFGRSGAGDAELDRALELASFRKDIAFLPEGLQTLVGEKGVALSGGQKQRVSIARALIADPEILMLDDALSAVDAKTEAEIIAGIRRERAGRTTLITTHRLSAVQHADLILVLDEGRVTEAGTHEELLALGGWYKEQYDRQQLESAAPGA
>NC_016935.1|WP_014371714.1|6687171_6689292_+|ABC-transporter-ATP-binding-protein
MNTDSRRTGARLFRYAMLFRRPILTALVLLTLAACAELAGPLIAKRMIDRHILGIEMAWYEAPGPGESTAAYSGKHYKRSDHWLPGEKPGTEVRIVQSGMGYYFAEGPFASDGTRTVDTSAPDAPLLTVTSPSGDRSTYPARQLTAPELYAFYAPEFRPLLMLAAGYFGLLVLSALFTYGQRYLLQISANRVIGRMREDVFAQVQRLPIQYFDNLPAGKVVSRITNDTESIRELYVAVLANFFSGIIYMTAIVGALFLLDTRLALIALPLFPLLYLWIKVYRRFAERYNEEIRSRLSDINGMINEAIGGMPIIRAFRRGRQTMEEFETLNGEHYTYQNKLLSLNSITSHNLVNVIRNVIFLGVIWMFGGGLLGAAVTVGVLYAFVDYMNRMFQPIVGIVNQLSNLETALVSANRVFELLDQEGTDVAEGRLDRYRGDVSFESVSFAYKENDYVLKEIGFEARQGQTVALVGHTGSGKSSILNLLFRFYDPQHGRITIDGRDIRDIPRQLLRQHMGIVLQDPYLFTGTIASNVSLGDPNISREKVEKALRDVGAYDMFSALPGGIDEPVIEKGSTLSAGQRQLISFARALAFDPAILILDEATASIDSETEAVIQSALEVLKRGRTTFIIAHRLSTIKNADIILVLDRGQIMERGNHAELMARKGRYYQMYLLQSGEALDGGRAEAAADAGREAAAPPAAAVPSTLS
>NC_016935.1|WP_014369723.1|6689579_6690596_+|transposase
MKARRGLPRNRLIPEKRIYFRPELTHCPDCGTKLKRHHTASHKIVATLKGILDVWNMAYHCPNEACGKLERYFRSAQADALCLKHTSYAYDVLVLVGEMRFKQHMTVTEISEALTQRAIPTSERHAMRLYEWYLTLLRASLTDDVKEDLKKIVKEHGGLLLSMDGVQPEKGNETLYVVREGFSGRILAAKNLKSGSCSELKALLKPVKDLDYPVVGLVSDGQRSIRMAMEETWGDTPYQYCQYHYLKDIAKPVVDLDRKLKTEIKKSLRGIREIEKQVEHESTVEAEVARDYLAATRSLLLEDGTPPLDLPGIRIYENAQAVKASLEQSEAKKGGLHS

Crispr_ID: NC_016935_14

• CRISPR_ID: NC_016935_14
• CRISPR_location: 6828670-6828744
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_016935_14

Consensus_repeat	Method
AATAGCGGAACTCCAGTGCCTTAT	CRISPRCasFinder

spacers of NC_016935_14

>14.1|6828694|27|NC_016935|CRISPRCasFinder
CCGGTTATTTCCCGTTATTTCCCGGAG

CRISPR arrays and Neighbor proteins around NC_016935_14

CRISPR arrays

The CRISPR arrays of NC_016935_14

>merge|NC_016935|14|6828670-6828744|CRISPRCasFinder
AATAGCGGAACTCCAGTGCCTTATCCGGTTATTTCCCGTTATTTCCCGGAGAATAACGGAACTCCAGTGCCTTAT

>NC_016935|14|10|6828670-6828744|CRISPRCasFinder
AATAGCGGAACTCCAGTGCCTTAT	CCGGTTATTTCCCGTTATTTCCCGGAG
AATAACGGAACTCCAGTGCCTTAT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016935.1|WP_013919818.1|6833285_6833432_-|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_014371785.1|6834946_6835429_+|hypothetical-protein	unknown	unknown	gnl|CDD|223682
NC_016935.1|WP_013919805.1|6815845_6816262_-|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_014652388.1|6818186_6818912_+|DUF1361-domain-containing-protein	unknown	unknown	gnl|CDD|369208
NC_016935.1|WP_014371789.1|6838368_6838830_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
NC_016935.1|WP_041619273.1|6836320_6837082_-|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_014371784.1|6834473_6834905_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|379228
NC_016935.1|WP_013919815.1|6827147_6828164_-|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl|CDD|224525
NC_016935.1|WP_014371778.1|6823185_6823785_+|histidine-phosphatase-family-protein	unknown	unknown	gnl|CDD|366010
NC_016935.1|WP_014371786.1|6835404_6836283_-|MBL-fold-metallo-hydrolase	unknown	unknown	gnl|CDD|293840
NC_016935.1|WP_013919812.1|6823846_6824440_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|366102
NC_016935.1|WP_014371777.1|6819051_6820311_-|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl|CDD|372371
NC_016935.1|WP_013919810.1|6822105_6822945_+|AraC-family-transcriptional-regulator	unknown	unknown	gnl|CDD|197666
NC_016935.1|WP_014371783.1|6830854_6833284_-|glycoside-hydrolase-family-6-protein	unknown	unknown	gnl|CDD|227616
NC_016935.1|WP_014371775.1|6816405_6818019_-|S-layer-homology-domain-containing-protein	unknown	unknown	gnl|CDD|119353
NC_016935.1|WP_014371782.1|6828994_6830734_-|cellulase-family-glycosylhydrolase	unknown	unknown	gnl|CDD|365907
NC_016935.1|WP_014371780.1|6824600_6825314_+|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223669
NC_016935.1|WP_013919819.1|6833866_6834283_-|VOC-family-protein	unknown	unknown	gnl|CDD|319899
NC_016935.1|WP_014371781.1|6825377_6826970_-|glycoside-hydrolase-family-28-protein	unknown	unknown	gnl|CDD|227721
NC_016935.1|WP_014371790.1|6838883_6839555_-|thiaminase-II	unknown	unknown	gnl|CDD|381701

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016935.1|WP_014371789.1|6838368_6838830_+|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	2.21869e-09
NC_016935.1|WP_014371785.1|6834946_6835429_+|hypothetical-protein	gnl|CDD|223682	COG0609, FepD, ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism].	0.00881915
NC_016935.1|WP_014652388.1|6818186_6818912_+|DUF1361-domain-containing-protein	gnl|CDD|369208	pfam07099, DUF1361, Protein of unknown function (DUF1361). This family consists of several hypothetical bacterial proteins of around 200 residues in length. The function of this family is unknown although some members are annotated as being putative integral membrane proteins.	3.73983e-32
NC_016935.1|WP_014371790.1|6838883_6839555_-|thiaminase-II	gnl|CDD|381701	cd19366, TenA_C_BhTenA-like, TenA_C proteins similar to Bacillus halodurans TenA. This family of TenA proteins belongs to the TenA_C class as it has a conserved active site Cys residue; the double Glu residues identified in the active site of TenA_E from the archaeon Pyrococcus furiosus is conserved in this family. TenA_C proteins (EC 3.5.99.2) catalyze the hydrolysis of the thiamin breakdown product 4-amino-5-amino-methyl-2-methylpyrimidine (amino-HMP) to 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP) in a thiamin salvage pathway. This family includes Bacillus halodurans TenA which participates in a salvage pathway where the thiamine degradation product 2-methyl-4-formylamino-5-aminomethylpyrimidine (formylamino-HMP) is hydrolyzed first to amino-HMP by the YlmB protein, and the amino-HMP is then hydrolyzed by TenA to produce HMP. It has also been suggested that TenA proteins act as transcriptional regulators based on changes in gene-expression patterns when TenA is overexpressed in Bacillus subtilis, however this effect may be indirect.	1.51735e-132
NC_016935.1|WP_014371784.1|6834473_6834905_+|GNAT-family-N-acetyltransferase	gnl|CDD|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	2.56605e-13
NC_016935.1|WP_013919815.1|6827147_6828164_-|LacI-family-DNA-binding-transcriptional-regulator	gnl|CDD|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.51965e-112
NC_016935.1|WP_014371778.1|6823185_6823785_+|histidine-phosphatase-family-protein	gnl|CDD|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	7.50964e-38
NC_016935.1|WP_014371786.1|6835404_6836283_-|MBL-fold-metallo-hydrolase	gnl|CDD|293840	cd16282, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily.Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	5.87945e-36
NC_016935.1|WP_014371783.1|6830854_6833284_-|glycoside-hydrolase-family-6-protein	gnl|CDD|227616	COG5297, CelA, Cellobiohydrolase A (1,4-beta-cellobiosidase A) [Carbohydrate transport and metabolism].	0
NC_016935.1|WP_014371777.1|6819051_6820311_-|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	gnl|CDD|372371	pfam12897, Aminotran_MocR, Alanine-glyoxylate amino-transferase. These proteins catalyze the reversible transfer of an amino group from the amino acid substrate to an acceptor alpha-keto acid. They require pyridoxal 5'-phosphate (PLP) as a cofactor to catalyze this reaction. Trans-amination reactions are of central importance in amino acid metabolism and in links to carbohydrate and fat metabolism. This class of aminotransferases acts as dimers in a head-to-tail configuration.	0
NC_016935.1|WP_013919810.1|6822105_6822945_+|AraC-family-transcriptional-regulator	gnl|CDD|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	1.12942e-25
NC_016935.1|WP_013919812.1|6823846_6824440_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	1.68093e-15
NC_016935.1|WP_014371775.1|6816405_6818019_-|S-layer-homology-domain-containing-protein	gnl|CDD|119353	cd02874, GH18_CFLE_spore_hydrolase, Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the forespore inner membrane and is deposited as a mature enzyme in the cortex layer of the spore. As part of a sensory mechanism capable of initiating germination, CFLE degrades a spore-specific peptidoglycan constituent called muramic-acid delta-lactam that comprises the outer cortex. CFLE has a C-terminal glycosyl hydrolase family 18 (GH18) catalytic domain as well as two N-terminal LysM peptidoglycan-binding domains. In addition to SleB, this family includes YaaH, YdhD, and YvbX from Bacillus subtilis.	5.63845e-33
NC_016935.1|WP_014371782.1|6828994_6830734_-|cellulase-family-glycosylhydrolase	gnl|CDD|365907	pfam00150, Cellulase, Cellulase (glycosyl hydrolase family 5).	2.78338e-75
NC_016935.1|WP_014371780.1|6824600_6825314_+|alpha/beta-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	2.83123e-27
NC_016935.1|WP_013919819.1|6833866_6834283_-|VOC-family-protein	gnl|CDD|319899	cd06588, PhnB_like, Escherichia coli PhnB and similar proteins. The Escherichia coli phnB gene is found next to an operon of fourteen genes (phnC-to-phnP) related to the cleavage of carbon-phosphorus (C-P) bonds in unactivated alkylphosphonates, supporting bacterial growth on alkylphosphonates as the sole phosphorus source. It was originally considered part of that operon. PhnB appears to play no direct catalytic role in the usage of alkylphosphonate. Although many of the proteins in this family have been annotated as 3-demethylubiquinone-9 3-methyltransferase enzymes by automatic annotation programs, the experimental evidence for this assignment is lacking. In Escherichia coli, the gene coding 3-demethylubiquinone-9 3-methyltransferase enzyme is ubiG, which belongs to the AdoMet-MTase protein family. PhnB-like proteins adopt a structural fold similar to bleomycin resistance proteins, glyoxalase I, and type I extradiol dioxygenases.	5.31191e-31
NC_016935.1|WP_014371781.1|6825377_6826970_-|glycoside-hydrolase-family-28-protein	gnl|CDD|227721	COG5434, PGU1, Endopygalactorunase [Cell envelope biogenesis, outer membrane].	1.27468e-85

Protein sequences

>NC_016935.1|WP_013919815.1|6827147_6828164_-|LacI-family-DNA-binding-transcriptional-regulator
MKATIYDVAREAGVSIATVSNAIRGKGKISPKKREEILEIVERLQYQPSMIASALTGKRTYTLGLLVPDISNPFFGEIARAVEERGQQLGYSVIICSTDNKDERVERYISLLEQKSVDGIIIGTGISDASLLERLSSRSVPVAMIARDLPSADVHKVVIDDYLGGVLAARHLLELGHRRFGVISEKHNRERIRGFCETVERSGQALSPCGIRIFGDDDQIQDGGRAAAELLELEARPTALFCCNDMSATGALRAAKARGLAVPRDISIVSFDNTILSEVCDPPMTTIAQPMEEMGRLVVDALLQELGDGGAKQRFVLQPELLVRGSTAAFVPEEQKNA
>NC_016935.1|WP_014371781.1|6825377_6826970_-|glycoside-hydrolase-family-28-protein
MSSIEPIVSGSSWTLSEVGQPSIPDRSFSVTDYGAVGDGVTDNTEAFHKAIAACSQAGGGRVVIPAGVWLTGPLSLASRLDLHAQAGALVLFSRRFEDYPMIFSQYEGQPSIRCQSPLDGEGLEHVAITGAGVFDGGGDAWRPVKDWKMTEKHWAKLIASGGVVDEDAGMWWPSEAAMNGPAKVAQLKREGSTDPKDYEAARDYLRPNLLSLRRCKYVLLEGATFQNSPAWNLHPWACEHVTLRGVTVRNPWYGQNGDGLDLDSCRYGLVEDCSFDVGDDAICIKSGKDEAGRALGIPCEDILIRNCRVYHGHGGFVIGSEMSGGVRRLRVEDCTFMGTDIGLRFKSTRGRGGLVEDIEIERIRMNSIVGEAISFHLFYEGKEGSGVAGENIVPVSVETPIFRGITIRDVQCAGAETALLINGLPEMPLDGLVVENFTASAKRGGVCTNAQNLTLKDVTLHVEQGPVVSLRHAQHVKIEGLGGSAPEGSDMLQVSGRGSKEIAYGGIRLPEELRGVKIAVEVEDKNSIRG
>NC_016935.1|WP_014371780.1|6824600_6825314_+|alpha/beta-hydrolase
MQMQMQTQVKQVELNGLLFQYRETGKISSPPIIALHAMGMTAETWDEAAAVLGETHRVLALNQRGHGGSARTGSYTFELMCEDMLAFADRMGLERFILLGHSMGGTVSYLFSQTYPSRVERLLVEDTPPPFAGKRFDIPPEPSEPLPFDWAVVPSIIGQLNEPDPQWWARLPAIQAPTLIIGGGVSSPIPQDKLKEVSGLIPICKLVTVDGGGHHVHSTRLPAFLAAVQSFLKDEPV
>NC_016935.1|WP_013919812.1|6823846_6824440_-|TetR/AcrR-family-transcriptional-regulator
MPRTPQENERIRGMAKEKIRAAAIEVFIEKGFHKASIDDVAKKAGISKGLLYNYFKGKTDLLAELVHTRKEEIVQVMEEAVRQASPKEQLLYIAEHALRSVERQPHVYRFYLHLQTHPEADEVVSAYSQTLKDEMARQAEVQAEIFRNLNAARPELESLQFSTMLHGIMLMYSSYPNGFPLEELKHDMVTSFINRYA
>NC_016935.1|WP_014371778.1|6823185_6823785_+|histidine-phosphatase-family-protein
MAAELYLVRHAKKEKGIGDAAISSEGMRQAQATARHFRGLPITQILCSPLQRAKMTAAIIAKGTGTVLTEDHRLRERANWGDIPGQTFEDFVEMWDRCTLDRDFSPPAGDSARQAGERLASCLLDLSASHPQGPLLVVTHGGLITDFLVQVIPEAELNKLHPRFIAEQSRLVAECSITTVRCEDGRFSLVDFAAVEHLL
>NC_016935.1|WP_013919810.1|6822105_6822945_+|AraC-family-transcriptional-regulator
MTERTGFKYTIGDTAFAIQQLQQTGVTSMPRPHSHEFYELYYLFHGERVYFIGGKVYTARKGDLMVVVPNDLHSTASSAVAEFERMLVHFSPSFLGEEGPGLMELPPFRESTLLSIPMKEQPELEHLLLQLHTECREQQPLYEACVRHLLGELLVRIHRRGLIEQEPPESVHPMHQKVTEIASYIHGHYQEDLTLGGVAKQFFISPAYLSRVFLKLTGFHFSEYIRVVRVREAQKLLRTTREKVQSISEQVGFEHISHFNKTFKRIAGLSPLQYRDQHR
>NC_016935.1|WP_014371777.1|6819051_6820311_-|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme
MESQPAFVHWESEELRDHHRRLTQRYEACRSQKMALDMSRGKPCPEQLELSREMLGIVAADDPLRAADGSDCLNYGGIDGIPEAQSLFARMLGVESKEILIGGNSSLTMMHDALTRAMLHGVYGSERPWGRLPKVKFLCPSPGYDRHFAICELLQIEMIVVDMLPSGPDMDQVERLVREDDSIKGIWCVPKYSNPDGITYSDAVVDRLSQMKTAAADFRIFWDDAYTVHHLTPEPNVLKNILAACRAAGNPDRVFLFCSTSKITFPGAGVAVLASSENNLGLIRRQLAVQTIGPDKINQHRHVRFLRDMDHLKTHMERHAAIIKPKFDLVLRKLEEELADKQIASWHKPNGGYFISLNTLDGCADEVVRMAAEAGVTLTKAGATFPYGKDPRNRNIRIAPTYPSLTELETAIDILCLCV
>NC_016935.1|WP_014652388.1|6818186_6818912_+|DUF1361-domain-containing-protein
MEGTIMNLNRLLPWVPLLTLLSLVTAACLLLSSRLGEAYDFLRWDVTLAWIPVPMALLFMLLDGLKARWVRRLLRALVAAVWLAFFPNSAYLVTELLHAFRFFEMQPGFWTGIDYWYRVMPIFGVACLGLALSASSLYLLHRWTSARLGALTGWFFAAAALALASFGVYIGRILRWNSWDLAARPQMIVTELAALYQDTSRWSHAVSFVELFFAVLFLSYGIFYTAIVLGAKGSPAPASLQ
>NC_016935.1|WP_014371775.1|6816405_6818019_-|S-layer-homology-domain-containing-protein
MTLLSLIQKTIPAAALLLLAATGSALAYDVSLKPFTDVSNGDWFQEEVYSLSAIGLIDGYPDATFQPDGMLTREAFLKLLVQSKSLDPAVPSGDAPADVEPSRWSYPYIAAAYERKWIDVLLDSRRALDPQRTITRGEVAAVAGRALLDAQPQEARERWMSQGWQEERERRKYADGDTIGEGLRPYAYYAVNRGIMEGDETGFHPQQPLTRKEAAAIFYRLIDAETAGAKLEHTGFYAIRSYPAIGRIPLLSQVTFGWSHLEYPSPGTARLNTEKTEYRIPSGWEEALGAAGSAKAGKELMVYYGDKNLKDFLKDEGAQNAFIDSLKAVLTDKKYGFSGVCMDLEGLLEPASAADYVQFLHRVKKSIPDYKLTVAVQPDYYYKGYDLKEIGGLADTVILMAYNFTHDESRLPSAPLPLVNDSVKRALALVPKEKLVLGISKQANQWVTAPDGGTDSFNPEIAEVEKRLGAPGVSQSMSYPYFLKRMAFQDERGSHEMYYEDTESIEKKLWLAKYYGLKGVSLWYMGNYTDSDWKLFE
>NC_016935.1|WP_013919805.1|6815845_6816262_-|hypothetical-protein
MKKLVVLACFFLLLGCKESDNKIKEIPYLPISPGDVSGMKITGDAMEDREASPEDREQIIKWINSVKHFESEFRGSDRLCPLRITIQVRSHGEIWVCYQDPYGGTSGAFGSLELTSKYQFSQKDLKKFFHRILQEQEK
>NC_016935.1|WP_014371782.1|6828994_6830734_-|cellulase-family-glycosylhydrolase
MKPFRLWGAWLSTAVAVLGLMLPFGAAYSQAAAAVPYGQLKVQGADLLGESGQRVQLRGMSSHGIHWYGDLVNPGSLKWLKEDWNSNLFRVAMYTAEKGYITDPSVKEKVKEAVQAAIDLGLYVIIDWHILTDGDPNTYKTQARAFFQEMAALYGQYPNVIYELCNEPNGNVTWAGQIKPYAQELTQAIRAIDPDNIIIVGTPNWSQDVNQAADSPLPYGNIMYAAHFYAGTHGQWLRDKIDYARSKGAAVFVTEWGASDASGDGGPFLREAQEWIDFMNSRGISWANWSLADKEETSAALLPGANPSGGWPASQLSASGQFVRSKLRESLVSVPAAPAGLKAAPGSGQAALSWNAVNGATGYIVKRAAVSGGPYTTVAELTGTSYTDTGLANGTTYYYVVSAKNAAGTGPVSAQVSVQPAAGQGGGGTPVPGSLVLQYRAADTNAGDNAIKPHFNIRNTGASPVDLSGVKLRYYFTKDGIQPLSFAVDWAQVGSPNVKGTFGSASGAGADTYLEVSFTGGSIPAGGQTGEIQTRIHKSDWSSFQESGDYSYDPGKTSYADWSKVTLYRDGTRVWGVEP
>NC_016935.1|WP_014371783.1|6830854_6833284_-|glycoside-hydrolase-family-6-protein
MRNSVWRKMSLVLAAAALLGGLLPAGAATSYAAEAHVDNPFAGATAYVNPDYAAQIDTSIAKVSDPALQAKMETLKSYPTAVWLDRIAAIGGGASNGGRRSLEGHLDAALAQKKGTAPITATFVIYDLPGRDCHALASNGELPLTQEGLQRYKTEYIDAIASIFANPKYRDIRIVTVIEPDGLPNLVTNLSDPKCAAANSSGIYIAGFQYALNKLHAIPNVYNYLDIGHSGWLGWDDNRRGAVTLYTNAVKGTTAGLASVDGFITNTANTTPLVEPYLTNPNLSINGQPIRSSKYYEWNPNFDETDFTAALYADFTAAGWPSTLGFLVDTGRNGWGGVNRPAGASGSDIDTYVNSGRIDRRAHRGLWCNNNGAGIGLPPQNAPAGYAASHIDALVWVKPPGESDGASKFIPNDEGKLADPNCDPTYTNADGVLTGAMPDAPLAGHWFHDQFVMLVQNAYPAIPGSGGGTPAVPAAPAGVKAAAGNAQVTLTWDASAGAASYTVKRASVSGGPYTTVAAGLTATSFTNTGLTNGTVYYYIVTASNAAGESAASVQVSAVPSSGVSVPAAPAGLTAAAGNAQVTLTWSASAGATSYTVKRATVSGGPYTTVATGLAATSYTNTGLTNGTAYYYVVSAVNSAGESANSAPVSAVPEGSVTPPAGSLAVQYRAGNTNAADNAISPHFNIKNNGTAAVNLSDLKIRYYFTKDGSAGLDSWVDWAQVGGANVQRVFGSASGTGADTYVEISFTAAAGSIPAGGQTGDIQLRMAKTDWSNFNETGDYSFDGTKTAYANWDKVTLYQGGKLVWGIEP
>NC_016935.1|WP_013919818.1|6833285_6833432_-|hypothetical-protein
MEQTKTVENGRSTPAAETAVLEMKCGEERGYNRSRWNPIQFSYERMGE
>NC_016935.1|WP_013919819.1|6833866_6834283_-|VOC-family-protein
MAKHNTYFFSEDARAQADFYVQALGGEIQAVMTNGQLPEAAEGTKDKVIHLSMVAAGVNFCLADAEYGPVSSGNAVSQCLTFATEAEAREAFEKLSEGGTVSQPLEPAFWGALFGQLEDKFGVQWMITTESQECQTPA
>NC_016935.1|WP_014371784.1|6834473_6834905_+|GNAT-family-N-acetyltransferase
METTYKQYVISDDPSKIQVETVVEFLAGSYWANLRQPERIRASIRSSVCYGVYDGDRMVGFARVVTDGATVYYVCDVFVLEAYRGQGISKKLVELITNAPEFEWMTGILGTRDAHGLYEQFGFQRDAQAYMKRLPKARRGEGE
>NC_016935.1|WP_014371785.1|6834946_6835429_+|hypothetical-protein
MFKKIVLTFAGLALFLVVVFVVWLQYGTRYNQIEVWQANWAFETPPEQRTTTVFEHVGRDPDQYVIVEYSAEAVEELRGRNTWHSAGVPGAVQAHVASFQSLMKELHSQESQVLEEQFRNHPVPSHERLLYLTRTKEDGSRMLAVLDAENRRLYVMEVFF
>NC_016935.1|WP_014371786.1|6835404_6836283_-|MBL-fold-metallo-hydrolase
MQTIEKVGERFWYQTPVSETDRPILGMVVGRERRLMIDAGNSEAHARYFLEELEERGIGAPDLAVLTHWHWDHIFGLEWLHQHAVSIASSGTREAMEKLVPFSWSDEALDRRVEEGTEIEFCASAIKKEFPLHRDIRIALPVMTFENRMELDLGGITCVLQHVGGDHAGDSVVVYIPEERILFLGDCIYADIFSAKRNYTPGKTLALLEVLETFDAETYVLSHWKPVSKAEFREEAALLRTMAQLTDEFAGDSARMREAYEKRKGRGLTEEELETLEYFVNGVVLQKKTSMT
>NC_016935.1|WP_041619273.1|6836320_6837082_-|hypothetical-protein
MLQKMASAGFAMLCLWALFLLMGGGYLSFRLMEEINLWGILYLYGAACSIIIDMFVRYLPSYRPLKEGLLYAFFGYCYFPAAGYLSKGAALSAGELFGTLLVTGTLGAITALIFWAGSRLASKHPRTSYLMGIVIPGVLFLSMTIVNDLKIGWKETFSNSTYEAAFDLFNGAREIPVELRKGQTLVFSFLWNVKGGSSTGHHALKPNGGYAVLQTTTDHKTAIRAEEDGVYRIVAKARGGGSGSFKVTWEIRD
>NC_016935.1|WP_014371789.1|6838368_6838830_+|GNAT-family-N-acetyltransferase
MIVRLALTDPETASNLLKVQTPSYLVEAELIGFHGIPALNDTVESLAQSGETFYGYFAGGELAGAAAYELDGGTMEITRLVVHPMFFRRGIGGSLIRFLLELNLGVKGYRVSTGAKNGPAKRLYTNCGFKEAGELEVAPEVFLTLLERGVAGQ
>NC_016935.1|WP_014371790.1|6838883_6839555_-|thiaminase-II
MTFTQRLLGKLEGVWRQNHSHPFVREMGAGTLDRDKFRFYMIQDYLYLIDYAKLFALGAVKANDLATMEKFAALLHSTLHEEMALHRAYAARFGISEEELETAEPSPITLAYSHYMLHAAQNGSLAELVAALLPCMWSYWEIGKELSRIPGAADHEDYGEWIRMYSSEEFEALAQWCIGLLDELAEGRSEAELARLEEIFLNTTRYEYMFWDMAYHGQMWPAG

Crispr_ID: NC_016935_15

• CRISPR_ID: NC_016935_15
• CRISPR_location: 6881004-6881078
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_016935_15

Consensus_repeat	Method
AATAGCGAACCTCAGTTCCGCTAT	CRISPRCasFinder

spacers of NC_016935_15

>15.1|6881028|27|NC_016935|CRISPRCasFinder
CTCCTGAATAGGTCCTTCGAGCGGCAG

CRISPR arrays and Neighbor proteins around NC_016935_15

CRISPR arrays

The CRISPR arrays of NC_016935_15

>merge|NC_016935|15|6881004-6881078|CRISPRCasFinder
AATAGCGAACCTCAGTTCCGCTATCTCCTGAATAGGTCCTTCGAGCGGCAGAATAGCGAACCTCAGTTCCGCTAT

>NC_016935|15|11|6881004-6881078|CRISPRCasFinder
AATAGCGAACCTCAGTTCCGCTAT	CTCCTGAATAGGTCCTTCGAGCGGCAG
AATAGCGAACCTCAGTTCCGCTAT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016935.1|WP_014371820.1|6884468_6887252_+|family-43-glycosylhydrolase	unknown	unknown	gnl|CDD|350130
NC_016935.1|WP_014371825.1|6897013_6897988_-|ROK-family-protein	unknown	unknown	gnl|CDD|224851
NC_016935.1|WP_014371810.1|6871658_6872831_+|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl|CDD|224090
NC_016935.1|WP_014371818.1|6881174_6882890_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224055
NC_016935.1|WP_014371816.1|6876897_6877089_+|YqaE/Pmp3-family-membrane-protein	unknown	unknown	gnl|CDD|376592
NC_016935.1|WP_013919876.1|6891823_6892606_+|amino-acid-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|270217
NC_016935.1|WP_014371821.1|6891220_6891412_-|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_187296796.1|6893362_6894103_+|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224051
NC_016935.1|WP_014371813.1|6875027_6875474_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
NC_016935.1|WP_013919868.1|6878518_6879490_-|hypothetical-protein	unknown	unknown	gnl|CDD|235571
NC_016935.1|WP_013919877.1|6892682_6893342_+|amino-acid-ABC-transporter-permease	unknown	unknown	gnl|CDD|223836
NC_016935.1|WP_063720043.1|6876339_6876792_+|hypothetical-protein	unknown	unknown	gnl|CDD|372952
NC_016935.1|WP_014371811.1|6873100_6873802_-|rhamnogalacturonan-acetylesterase	unknown	unknown	gnl|CDD|238859
NC_016935.1|WP_013919869.1|6879707_6880667_-|D-2-hydroxyacid-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|240646
NC_016935.1|WP_014371817.1|6877166_6878057_-|aminoglycoside-6-adenylyltransferase	unknown	unknown	gnl|CDD|377357
NC_016935.1|WP_014371823.1|6895279_6895993_-|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein	unknown	unknown	gnl|CDD|336781
NC_016935.1|WP_014371824.1|6896294_6896618_-|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_014371814.1|6875500_6876058_-|DUF1700-domain-containing-protein	unknown	unknown	gnl|CDD|227053
NC_016935.1|WP_013919867.1|6878092_6878485_-|immunity-22-family-protein	unknown	unknown	gnl|CDD|379476
NC_016935.1|WP_014371826.1|6898218_6898809_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016935.1|WP_014371820.1|6884468_6887252_+|family-43-glycosylhydrolase	gnl|CDD|350130	cd18618, GH43_Xsa43E-like, Glycosyl hydrolase family 43, including Butyrivibrio proteoclasticus arabinofuranosidase Xsa43E. This glycosyl hydrolase family 43 (GH43) subgroup belongs to the GH43_AXH-like subgroup which includes enzymes that have been characterized with beta-xylosidase (EC 3.2.1.37), alpha-L-arabinofuranosidase (EC 3.2.1.55), alpha-1,2-L-arabinofuranosidase 43A (arabinan-specific; EC 3.2.1.-), endo-alpha-L-arabinanase as well as arabinoxylan arabinofuranohydrolase (AXH) activities. GH43 are inverting enzymes (i.e. they invert the stereochemistry of the anomeric carbon atom of the substrate) that have an aspartate as the catalytic general base, a glutamate as the catalytic general acid and another aspartate that is responsible for pKa modulation and orienting the catalytic acid. Many GH43 enzymes display both alpha-L-arabinofuranosidase and beta-D-xylosidase activity using aryl-glycosides as substrates. AXHs specifically hydrolyze the glycosidic bond between arabinofuranosyl substituents and xylopyranosyl backbone residues of arabinoxylan. This subgroup includes Cellvibrio japonicus arabinan-specific alpha-1,2-arabinofuranosidase, CjAbf43A, which confers its specificity by a surface cleft that is complementary to the helical backbone of the polysaccharide, and Butyrivibrio proteoclasticus GH43 enzyme Xsa43E, also an arabinofuranosidase, which has been shown to cleave arabinose side chains from short segments of xylan. Several of these enzymes also contain carbohydrate binding modules (CBMs) that bind cellulose or xylan. A common structural feature of GH43 enzymes is a 5-bladed beta-propeller domain that contains the catalytic acid and catalytic base. A long V-shaped groove, partially enclosed at one end, forms a single extended substrate-binding surface across the face of the propeller.	1.76909e-150
NC_016935.1|WP_014371825.1|6897013_6897988_-|ROK-family-protein	gnl|CDD|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	3.54696e-67
NC_016935.1|WP_014371810.1|6871658_6872831_+|pyridoxal-phosphate-dependent-aminotransferase	gnl|CDD|224090	COG1168, MalY, Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism].	0
NC_016935.1|WP_014371818.1|6881174_6882890_-|ABC-transporter-ATP-binding-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	0
NC_016935.1|WP_014371816.1|6876897_6877089_+|YqaE/Pmp3-family-membrane-protein	gnl|CDD|376592	pfam01679, Pmp3, Proteolipid membrane potential modulator. Pmp3 is an evolutionarily conserved proteolipid in the plasma membrane which, in S. pombe, is transcriptionally regulated by the Spc1 stress MAPK (mitogen-activated protein kinases) pathway. It functions to modulate the membrane potential, particularly to resist high cellular cation concentration. In eukaryotic organisms, stress-activated mitogen-activated protein kinases play crucial roles in transmitting environmental signals that will regulate gene expression for allowing the cell to adapt to cellular stress. Pmp3-like proteins are highly conserved in bacteria, yeast, nematode and plants.	7.66444e-12
NC_016935.1|WP_013919876.1|6891823_6892606_+|amino-acid-ABC-transporter-substrate-binding-protein	gnl|CDD|270217	cd00996, PBP2_AatB_like, Polar amino acids-binding domain of ATP-binding cassette transporter-like systems that belong to the type 2 periplasmic binding fold protein superfamily. This subfamily includes periplasmic binding domain of ATP-binding cassette transporter-like systems that serve as initial receptors in the ABC transport of amino acids and their derivatives in eubacteria. After binding their ligand with high affinity, they interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically-located ATPase. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The Abp proteins belong to the PBPI superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	3.38609e-118
NC_016935.1|WP_013919877.1|6892682_6893342_+|amino-acid-ABC-transporter-permease	gnl|CDD|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	4.00872e-68
NC_016935.1|WP_187296796.1|6893362_6894103_+|amino-acid-ABC-transporter-ATP-binding-protein	gnl|CDD|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	8.00655e-141
NC_016935.1|WP_014371813.1|6875027_6875474_+|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.07679e-07
NC_016935.1|WP_013919868.1|6878518_6879490_-|hypothetical-protein	gnl|CDD|235571	PRK05704, PRK05704, 2-oxoglutarate dehydrogenase complex dihydrolipoyllysine-residue succinyltransferase.	0.00202153
NC_016935.1|WP_063720043.1|6876339_6876792_+|hypothetical-protein	gnl|CDD|372952	pfam14184, YrvL, Regulatory protein YrvL. YrvL prevents expression and activity of the YrvI sigma factor. It may function as an anti-sigma factor.	2.96415e-22
NC_016935.1|WP_014371811.1|6873100_6873802_-|rhamnogalacturonan-acetylesterase	gnl|CDD|238859	cd01821, Rhamnogalacturan_acetylesterase_like, Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are highly branched regions in pectic polysaccharides, consisting of repeating -(1,2)-L-Rha-(1,4)-D-GalUA disaccharide units, with many rhamnose residues substituted by neutral oligosaccharides such as arabinans, galactans and arabinogalactans. Extracellular enzymes participating in the degradation of plant cell wall polymers, such as Rhamnogalacturonan acetylesterase, would typically be found in saprophytic and plant pathogenic fungi and bacteria.	6.31775e-89
NC_016935.1|WP_013919869.1|6879707_6880667_-|D-2-hydroxyacid-dehydrogenase-family-protein	gnl|CDD|240646	cd12169, PGDH_like_1, Putative D-3-Phosphoglycerate Dehydrogenases. Phosphoglycerate dehydrogenases (PGDHs) catalyze the initial step in the biosynthesis of L-serine from D-3-phosphoglycerate. PGDHs come in 3 distinct structural forms, with this first group being related to 2-hydroxy acid dehydrogenases, sharing structural similarity to formate and glycerate dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily, which also include groups such as L-alanine dehydrogenase and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. Many, not all, members of this family are dimeric.	0
NC_016935.1|WP_014371817.1|6877166_6878057_-|aminoglycoside-6-adenylyltransferase	gnl|CDD|377357	pfam04439, Adenyl_transf, Streptomycin adenylyltransferase. Also known as Aminoglycoside 6- adenylyltransferase (EC:2.7.7.-), this protein confers resistance to aminoglycoside antibiotics.	1.7964e-168
NC_016935.1|WP_014371823.1|6895279_6895993_-|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein	gnl|CDD|336781	pfam07722, Peptidase_C26, Peptidase C26. These peptidases have gamma-glutamyl hydrolase activity; that is they catalyze the cleavage of the gamma-glutamyl bond in poly-gamma-glutamyl substrates. They are structurally related to pfam00117, but contain extensions in four loops and at the C-terminus.	8.09789e-77
NC_016935.1|WP_014371814.1|6875500_6876058_-|DUF1700-domain-containing-protein	gnl|CDD|227053	COG4709, COG4709, Predicted membrane protein [Function unknown].	1.0306e-07
NC_016935.1|WP_013919867.1|6878092_6878485_-|immunity-22-family-protein	gnl|CDD|379476	pfam14112, DUF4284, Immunity protein 22. A predicted immunity protein with an alpha+beta fold and conserved tryptophan,tyrosine and an acidic residues. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, which usually contains toxin domains of the ColD/E5, Tox-REase-4, Ntox49 or Ntox14 families. The domain is also found in heterogeneous polyimmunity loci.	1.76904e-35

Protein sequences

>NC_016935.1|WP_013919869.1|6879707_6880667_-|D-2-hydroxyacid-dehydrogenase-family-protein
MKLRCAVLDDYQRAAASLADWSSLEDRVEVEFFHEHEDDEDKLAAALERFEIIVIMRERTPFRASLLGRLPRLKLLVTTGMRNASVDLAAAAGQGVAVCGTRGNPEPTPELTWALILGLARRLVPEHQALRSNGPWQSTLGIDLYGKRLGLLGLGTVGSRVARVGLAFGMEVAAWSPNLTAERAAEVGVQLAASKEELLESSDFVSVHLVLGDRSRGLLGREELKRMRPTAYLINTSRAPIVDREALVEALQEGWIAGAGVDVYDREPLPADDVFRTLPNVLTTPHLGYVTERNYRTFYGDAVEDIRAFLAGEPVRKLN
>NC_016935.1|WP_013919868.1|6878518_6879490_-|hypothetical-protein
MHRTWIIVLVGGIAAAAGLSLLGSAREELAPTPGSASPALGTEAHSPEHDGGPASKPGLVITQIAEGQTVVLDTAGGRPTRETGGEAGPSEPAGPSQEAVPPETAVPGQEALSSEPAAAGHEALPLLEPAAPGIAAGTVVGEGKADADGDGRTDTVRIRMTEGEERTDPNPGAFEGTHLHGTFEAVAETSDGRELSRFPLNGAFGGGEMIFRKGEPFRLLFDDYNDDGRPDFTVGQWGGSNGNFYVLLTIGPEGFQVLAKEIYSADHRESIRYRRTGKLAFRNIYYDQTRGAYMEVIRRWKDGAFAAEAPREIQDVGSAGVDP
>NC_016935.1|WP_013919867.1|6878092_6878485_-|immunity-22-family-protein
MDKDLTDGSRVSLWLGSWSSEEAAKAYVEGSYTEDGDYVPSPFERDFAFRYDPDFIELNFKETPAADWESLLQGHSYDEEIIPAFMEEIGPLSRSFNTVILVYNLAYDAEHLRSGTAAGELEYIGQAAYD
>NC_016935.1|WP_014371817.1|6877166_6878057_-|aminoglycoside-6-adenylyltransferase
MRSEREMMDTILSFANEEEGIRAVIMNGSRVNPKARRDPFQDYDIVFFVRQVGPFVRDRSWIRRFGGMMIMQTPDEMETEPDVTGEYSRFAFLMQFADGNRIDLTLIPYERRDKLPGDSLSVLLLDKAGTLEPYPPPSDRDYLTQPPAPQSFAACCNEFWWVSTYVAKGLWRRELPYAKTMMEGPVRSMLVRMLEWHVGIHSGFTAATGKAGKHLEKHLAPKLWEAYVGTYADGDYERIWEALFAMGGLFRETAQDVASHFGYAYPEEDDRRVTAHLHYVRALPEDAVELYGEADG
>NC_016935.1|WP_014371816.1|6876897_6877089_+|YqaE/Pmp3-family-membrane-protein
MMYLLAILLPPVAVLLSGKPFQAFLNLILTLCFWLPGAIHACMVVHEKKQDRRMERLQRGLYK
>NC_016935.1|WP_063720043.1|6876339_6876792_+|hypothetical-protein
MSFKEKTLAVSAFALFLVFVLIFVLAAVFFLFTGTFHLLGIEYDSWRSVFVFIGAGFVADLALGFLLLFPKVLCTLYFARSPRWQLFLFLLLLQFTFDLISVHYIDEWMDGVSIGSGAEAAFVLIMLALDKLLPDRKKEKWAQGPPQGMS
>NC_016935.1|WP_014371814.1|6875500_6876058_-|DUF1700-domain-containing-protein
MSPERKQFLSLISLHLSGLPEGERSEAVRKADRQIDHAVRSGLTEQAALIRLGDPKVIAEEYRGQARESKRGARSFKGVLRLIGFCCTTGLLTAIVVPFLAALAYGFGISSILIFAAGLLRTFGVPWIPLNLGPGLAIPAEYSMAATLIGGVVTGWIGYVSGGVLKKYLAFLSASYRRVQPGQSC
>NC_016935.1|WP_014371813.1|6875027_6875474_+|GNAT-family-N-acetyltransferase
MSLLIRCAEPQDLLPLSGLMHDYIVGFYGNPWPGDDRIHNLIRSLLERQAGVQFVAEREDALIGFATLYFTYSTMKANPITIMNDFFLLEPYRGTEAETRLFTHCRSFSLDNGFSYMSWITGTGNERAQRFFDEAGALRGSWVNYSII
>NC_016935.1|WP_014371811.1|6873100_6873802_-|rhamnogalacturonan-acetylesterase
MREDRRVTVYIAGDSTAANYPEDKRPMSGWGEWIASYLAEEVRVSNRARNGRSSKSFIAEGHFDRIASSIGEGDYLLVQFGHNDEKPDEKRHTDPGSTYEEHLTRYIEMARSKGAHPLLLTSVERRKFNEVGELVPSHGDYPAAVQRLAEKLEVPLLDLCSRTQEAYRKLGAEASKAWFVWLEPGEHPNYPEGERDDTHFNELGAQKVAGLVAEALAASGSPLAGYLKAGAAG
>NC_016935.1|WP_014371810.1|6871658_6872831_+|pyridoxal-phosphate-dependent-aminotransferase
MAYDFDRLIDRRNTRSYKWDQGAKLFGDPDILPLWVADMDFLAPPAVREVLEKRAALGVYGYAVRTESYLASIVNWYRRRHGWTVEPGWITDSPSIVTSLSLAVELFTEPGGEVVLQSPVYYPFYDVILGNGRKVAKNPLVIRNNRFEMDYEHLESLFQGGAKLLLLCSPHNPGGRVWEREELLRLGELCLRYGVTVVSDEIHCDLALSGHKHIPFASLSPELADITMTCLAATKTFNLPGLHTSYVVTSNASLRRRLEHRIKTLSIHMASHFAQDAVEAAYNEGEPWLDEMLAYVEGNLDYAIGFLAEHLPEVKPLRPDGTYLLWVDCRGLNLDIKGLKDLMFNRAKVAFSEGSVFGTEGEGWLRINLACPRSILEEALQRFCGAAVPQ
>NC_016935.1|WP_014371818.1|6881174_6882890_-|ABC-transporter-ATP-binding-protein
MLRRFFSYYRPYRGLFLLDFGCAVVAGLLELGFPLAVNQFVDKLLPGQNWPLILWACAALLFIYVLNTALQYVVTYWGHMLGINIETDMRRKLFDHIQKLSFRFFDNNKTGHLMTRITNDLNEIGEIAHHGPEDIFIAVMTLLGAFGLMLTINWKLAVLTFVIIPLMAWFALHFSSRMTRTYERLFGDVGEFNTRVENNIGGIRVVQAFANEEYEKELFKVNNQQYRLTKLLAYKLMAKSMSITYMMMRLVSVFVMIAGTWFVIRGELSYGEFVGFLLLSNVFFRPIEKINAVIESYPKGIAGFKRYCAILDTEPDVADAPDAVAAGPLNGDIVFRSVSFGYDGSKQILKGLNLSIRAGETVAFVGPSGAGKTTICSLLPRFYECSEGSITIDGMDIRRMTLQSLRSQIGIVQQEVYLFEGTIRQNIAYGKLDAGDEEIWEAARRAQLEEFIRKQPDGMQTQIGERGVKLSGGQKQRLAIARMFLKNPPILILDEATSALDTATELAIQQSLAELSAGRTTLVIAHRLATIKNADRIIVVTEDGVAEEGAHQELVAAGGMYSRLHQAQFGT
>NC_016935.1|WP_014371820.1|6884468_6887252_+|family-43-glycosylhydrolase
MKKWASTLVLAVLLSSAGTPAAYADNPVIKDVFTGDPAAFVHGDKVYLYTGHDEAAPNGNFFVMKDWLIFSSSDLVNWTREGSLDLSTFAWAQPNSAWASQLTERDGTFYWYVTVLNQDGTGYSIGVATSDNPISGFKDALGKPLVSSPMTQAPESMGTAPWDDIDPSVFIDDDGQAYLYWGNTHCYYAKLKPNMTELDGEIHRVTINNMEGTYTEAPWIHKHNGTYYLSFAHNYPEELAYATSSSPAGPWEYQGLLLDALTKDGSDPAASNTSHQSIIEFKGKSYLVYHNSALPTGGQYRRSVAIDRLHYNEDGTIRKVIPTSTGLDGTAHKLQSYTNPAKYVRHLDGDVRLDPVDSSVFDSKWHIVPGLADSGAGYVSLQSVDRPGYYLRYSGSDASLGKHDGTPAFAESATFKVNPGLANASLSSFEAYSQPGHYLRHAGSQLKVEAVSGEAAEADATFRTAEADVRGLTLDQQSLLLQKGTQTVLTASVQPASALNPKVIFTSSDPNVAAVGAPNVHPENGTMTVTVQAKSPGTATLTARTEEGQYTSSADVTVEAAGTAGAITNVKIGVSAEAKKVTIEGQSTYGAGNEIAVRVRKPDGTVDFLDQTTSGDGGSFTFGIPLANPVKGEYQVSLGAADVSEPFTAKFEYTPAAAGGNPGGGHSGSDSGGGSDSGSGNSSDDDDDDNGSGSGTVGNSAPAAGSGTASPGQSGGSAHGGSHASGPKPGSAKPAAPVFRDVQEGYSWAQEAIEALAAQGIIQGTSESTFEPGRPVSRADFITLLVRAFGLKGTLQGGSFADVQPGDYYYEAVSLARSLGLADGVDGSRFDPQAEISRQDMMVLIARALKLTNKAELGGSPDGLKAFADAADVADYAAESTAALIQAGVIQGDGGALHPRSSATRAETAVMLHRIWNTFLKEGGPSQ
>NC_016935.1|WP_014371821.1|6891220_6891412_-|hypothetical-protein
MTVHDLRQRIQYMQYLGFDEAKKMWVYTYREKYKHRGVFGLVSGKEKVVVLPSLHGLNLKKAF
>NC_016935.1|WP_013919876.1|6891823_6892606_+|amino-acid-ABC-transporter-substrate-binding-protein
MKKRLAAIGLVLTAAFTILTGCSGDTGAAGGDKKLVVGIDDKFAPMGFRDEKNEIVGFDIDYAKAAAEKMGTEVEFQPIDWKTKESELNSGRIDLIWNGYTITEERKGKVLFTKPYLKNAQVVVTLAKSNLSKLDELEGKTVGLQSLSSAADALNASPVKSKIKTVTEYADNVLALSDLKIGRVDAVVIDEVVVKYYMAKEKDTFKLMSESLAPEEYGVGVKKGNEELLQKLQKALDELNQDGTAAKISQKWFGEDKVLK
>NC_016935.1|WP_013919877.1|6892682_6893342_+|amino-acid-ABC-transporter-permease
MSAGDYISMIKPMLEGAQMTVLLFLIAIAASIPLGFVLTLAVKSSIKPISWLAHSYIYVMRGTPLLLQLLFICFGLPMIPGIGEFLVLDRFAAACLGFILNYAAYFAEIFRGGLLAIDKGQYEASQVLGLSKWQTTTRIILPQMFRVALPSVSNESITLVKDTALLYAVAVPELLHYAQTVVNRDFTIVPFFFAGVIYLIMTLALTAFFKWLEQRFKFE
>NC_016935.1|WP_187296796.1|6893362_6894103_+|amino-acid-ABC-transporter-ATP-binding-protein
MIEVSGLKKSYGTLDVLKRITFDVSKNDVVAVIGPSGSGKSTMLRSLVHLEEVNGGTIRVAGEDLVRDGVYSKPQEIKRITAKMGMVFQHFNLFPHLTVQENLELAPRLVKGESSEALRRRSSELLEKVGLTGRAAAYPAKLSGGQKQRVAIARALMMNPEILLFDEPTSALDPELTGEVLQVMKSLAEEHMTMIVVTHEMGFAREVASRVLFMDNGEIIESGPPEQLFGSPQHERTKAFLGRSYQ
>NC_016935.1|WP_014371823.1|6895279_6895993_-|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein
MKKPMIGVLPLYDEEKESYWMLPGYMKGIEAAGGIPVMLPLTADPEVITAMAHTFDGFLFTGGHDVHPELYGERVEPVCGEPCRERDEMERMLFREVTAMDKPAFGICRELQLFNALLGGTLYQDIPTQFGSDIQVNHQQQPPYDQPVHRVYIEKGDPLHEMLQTDSMEVNSYHHQGIKQLSSQLVAAAKAEDGMIEAVRMPDKKFVLAVQWHPEFSYTSDPYNFRLFEEFVSSCKS
>NC_016935.1|WP_014371824.1|6896294_6896618_-|hypothetical-protein
MSYELHITRASHWADSKQQPILLDELKTYFSTQSDFRYSDEVTVTGPFTVTLKGDFFIWRTEDQEIPFMYSRGKLSCSYGEDEVIMKMKSIAAELHAIVQGDEGEMY
>NC_016935.1|WP_014371825.1|6897013_6897988_-|ROK-family-protein
MDKYIIGIDLGGTNIKSAVFTSEFEPILERSDSTDAGLGPAHVLGKIKIIIKTMLLESGIDRHSVLCMGMGIPGLLDPREGISIFSPNFPHWENIHVVKEMQREFPFPVFIDNDVRLNLYGEWLHGAGVGRRNIVLLTLGTGLGSGILADGRVLYGQTSSAGEIGHMNMVREGRPCRCGSSGCLGRYVSATGMVRTFTEELDQGRESLIRSWVKNDSQQITAKMISDAYDLGDPLAIEVMHETGRLLGFGLATFINLLNPELVIIGGGMSAAGDRLLGTVRDTIRKHALKLSSEACQVVQAALGGRSGMLGAAVYAARRVEGKW
>NC_016935.1|WP_014371826.1|6898218_6898809_+|hypothetical-protein
MESLATGFKFILRGIAFLFYFPVHLFVSLLRFVWKRVLAPPLARTWRHIVVPATVFIENYVLSPLWRYALLYPARWIYVELLAPFLRFMWDRVLVPFLIFLWAGIVFPVFYFIVHYVLKFVWIVVLAPLYRHVLIPVLLFSEKAAKWLFRGITWLWMHAVYLPARRVGTRLLLPPIRWVHTELIVPVICWFRVLFT

Crispr_ID: NC_016935_16

• CRISPR_ID: NC_016935_16
• CRISPR_location: 6978433-6978568
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NC_016935_16

Consensus_repeat	Method
AATAGCGGAACTCCGATGCCTTAT	CRISPRCasFinder

spacers of NC_016935_16

>16.1|6978457|27|NC_016935|CRISPRCasFinder
TCGACTATTTCCCATCATTTCCCGAAG
>16.2|6978508|37|NC_016935|CRISPRCasFinder
AAGGGGAAAATGGCCTGGAAACGGTGCTCCTCCCTAC

CRISPR arrays and Neighbor proteins around NC_016935_16

CRISPR arrays

The CRISPR arrays of NC_016935_16

>merge|NC_016935|16|6978433-6978568|CRISPRCasFinder
AATAGCGGAACTCCGATGCCTTATTCGACTATTTCCCATCATTTCCCGAAGAATAGCGGAACTCCGATGCCTTATAAGGGGAAAATGGCCTGGAAACGGTGCTCCTCCCTACAATAGCGCATCTGAGTTCCTTTAT

>NC_016935|16|12|6978433-6978568|CRISPRCasFinder
AATAGCGGAACTCCGATGCCTTAT	TCGACTATTTCCCATCATTTCCCGAAG
AATAGCGGAACTCCGATGCCTTAT	AAGGGGAAAATGGCCTGGAAACGGTGCTCCTCCCTAC
AATAGCGCATCTGAGTTCCTTTAT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016935.1|WP_013919948.1|6974848_6975820_-|sugar-ABC-transporter-permease	unknown	unknown	gnl|CDD|226666
NC_016935.1|WP_014371868.1|6981479_6983288_-|sensor-histidine-kinase	unknown	unknown	gnl|CDD|225519
NC_016935.1|WP_013919956.1|6986100_6987090_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|224093
NC_016935.1|WP_013919955.1|6985041_6986064_-|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|380660
NC_016935.1|WP_014371862.1|6968311_6969307_-|family-43-glycosylhydrolase	unknown	unknown	gnl|CDD|350095
NC_016935.1|WP_014371870.1|6987102_6988593_-|sugar-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224053
NC_016935.1|WP_013919942.1|6965520_6966198_+|cupin-domain-containing-protein	unknown	unknown	gnl|CDD|380440
NC_016935.1|WP_014371866.1|6979746_6980382_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228
NC_016935.1|WP_014371861.1|6966334_6967402_-|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl|CDD|380629
NC_016935.1|WP_014371872.1|6989984_6992261_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|225117
NC_016935.1|WP_014371863.1|6972301_6973882_-|DUF3502-domain-containing-protein	unknown	unknown	gnl|CDD|270298
NC_016935.1|WP_014371867.1|6980466_6981483_-|substrate-binding-domain-containing-protein	unknown	unknown	gnl|CDD|380661
NC_016935.1|WP_014371869.1|6983284_6984913_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|381091
NC_016935.1|WP_013919938.1|6959368_6960256_-|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl|CDD|223472
NC_016935.1|WP_014371873.1|6992368_6993538_-|mandelate-racemase/muconate-lactonizing-enzyme-family-protein	unknown	unknown	gnl|CDD|227284
NC_016935.1|WP_013919944.1|6967622_6968108_+|heme-degrading-domain-containing-protein	unknown	unknown	gnl|CDD|179430
NC_016935.1|WP_014371864.1|6976266_6977862_-|diguanylate-cyclase	unknown	unknown	gnl|CDD|143635
NC_016935.1|WP_014371871.1|6988784_6989900_-|glycoside-hydrolase-family-88-protein	unknown	unknown	gnl|CDD|226678
NC_016935.1|WP_041619279.1|6960338_6961292_-|ABC-transporter-permease-subunit	unknown	unknown	gnl|CDD|226666
NC_016935.1|WP_014652445.1|6973928_6974822_-|ABC-transporter-permease-subunit	unknown	unknown	gnl|CDD|223472

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016935.1|WP_013919948.1|6974848_6975820_-|sugar-ABC-transporter-permease	gnl|CDD|226666	COG4209, LplB, ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism].	9.28749e-98
NC_016935.1|WP_014371868.1|6981479_6983288_-|sensor-histidine-kinase	gnl|CDD|225519	COG2972, COG2972, Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms].	1.311e-70
NC_016935.1|WP_013919956.1|6986100_6987090_-|ABC-transporter-permease	gnl|CDD|224093	COG1172, AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism].	3.58813e-81
NC_016935.1|WP_013919955.1|6985041_6986064_-|ABC-transporter-substrate-binding-protein	gnl|CDD|380660	cd20005, PBP1_ABC_sugar_binding-like, monosaccharide ABC transporter substrate-binding protein such as CUT2. Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems that share homology with a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein superfamily, which consists of two domains connected by a three-stranded hinge. The substrate specificity of this group is not known, but it is predicted to be involved in the transport of sugar-containing molecules and chemotaxis.	2.06299e-139
NC_016935.1|WP_014371862.1|6968311_6969307_-|family-43-glycosylhydrolase	gnl|CDD|350095	cd08981, GH43_Bt1873-like, Glycosyl hydrolase family 43 protein such as Bacteroides thetaiotaomicron BT_1873. This glycosyl hydrolase family 43 (GH43) subfamily includes Bacteroides thetaiotaomicron VPI-5482 endo-arabinase (Bt1873;BT_1873), as well as uncharacterized enzymes similar to those with beta-1,4-xylosidase (xylan 1,4-beta-xylosidase; EC 3.2.1.37), beta-1,3-xylosidase (EC 3.2.1.-), alpha-L-arabinofuranosidase (EC 3.2.1.55), arabinanase (EC 3.2.1.99), xylanase (EC 3.2.1.8), endo-alpha-L-arabinanase and galactan 1,3-beta-galactosidase (EC 3.2.1.145) activities. These are inverting enzymes (i.e. they invert the stereochemistry of the anomeric carbon atom of the substrate) that have an aspartate as the catalytic general base, a glutamate as the catalytic general acid and another aspartate that is responsible for pKa modulation and orienting the catalytic acid. Many of the GH43 enzymes in this family may display both alpha-L-arabinofuranosidase and beta-D-xylosidase activity using aryl-glycosides as substrates. A common structural feature of GH43 enzymes is a 5-bladed beta-propeller domain that contains the catalytic acid and catalytic base. A long V-shaped groove, partially enclosed at one end, forms a single extended substrate-binding surface across the face of the propeller.	5.12554e-147
NC_016935.1|WP_014371870.1|6987102_6988593_-|sugar-ABC-transporter-ATP-binding-protein	gnl|CDD|224053	COG1129, MglA, ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism].	0
NC_016935.1|WP_013919942.1|6965520_6966198_+|cupin-domain-containing-protein	gnl|CDD|380440	cd20306, cupin_OxDC-like, Oxalate decarboxylase (OxDC)-like cupin domain. This subfamily contains bacterial and eukaryotic cupin domains of proteins homologous to oxalate decarboxylase (OxDC; EC 4.1.1.2) such as MSMEG_2254, a putative OxDC from Mycobacterium smegmatis. OxDC is a manganese-dependent bicupin that catalyzes the conversion of oxalate to formate and carbon dioxide, utilizing dioxygen as a cofactor. It is evolutionarily related to oxalate oxidase (OxOx or germin; EC 1.2.3.4) which, in contrast, converts oxalate and dioxygen to carbon dioxide and hydrogen peroxide. OxDC is classified as a bicupin because it contains two cupin folds with each domain containing one manganese binding site, with four manganese binding residues (three histidines and one glutamate) conserved as well as a number of hydrophobic residues.	3.40685e-50
NC_016935.1|WP_014371866.1|6979746_6980382_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	6.03315e-08
NC_016935.1|WP_014371861.1|6966334_6967402_-|LacI-family-DNA-binding-transcriptional-regulator	gnl|CDD|380629	cd19974, PBP1_LacI-like, ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors. This group includes the ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type 1 periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.	2.51029e-91
NC_016935.1|WP_014371872.1|6989984_6992261_-|helix-turn-helix-domain-containing-protein	gnl|CDD|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	9.887e-28
NC_016935.1|WP_014371863.1|6972301_6973882_-|DUF3502-domain-containing-protein	gnl|CDD|270298	cd13580, PBP2_AlgQ_like_1, Periplasmic-binding component of alginate-specific ABC uptake system-like; contains the type 2 periplasmic binding fold. This subgroup includes uncharacterized periplasmic-binding proteins that are closely related to high molecular weight (HMW) alginate bining proteins (AlgQ1 and AlgQ2) found in gram-negative soil bacteria. The HMW alginate uptake system is composed of a novel pit formed on the cell surface and a pit-dependent ATP-binding cassette (ABC) transporter in the inner membrane. The transportation of HMW alginate from the pit to the ABC transporter is mediated by periplasmic HMW alginate-binding proteins (AlgQ1 and AlgQ2). Alginate is an anionic polysaccharide that is made up of alpha-L-mannuronate and its 5'-epimer, alpha-L-guluronate. Alginate is present in the cell walls of brown seaweeds, where it forms a viscous gum by binding water. Alginate is also produced by two bacteria genera Pseudomonas and Azotobacter. AlgQ1 and AlgQ2 belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. However, unlike other bacterial periplasmic-binding proteins that deliver small solutes to ABC transporters, AlgQ1/2 can bind a macromolecule and may have specificity for either sugar or a certain type of polysaccharide.	1.04578e-28
NC_016935.1|WP_014371867.1|6980466_6981483_-|substrate-binding-domain-containing-protein	gnl|CDD|380661	cd20006, PBP1_ABC_sugar_binding-like, monosaccharide ABC transporter substrate-binding protein such as CUT2. Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems that share homology with a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein superfamily, which consists of two domains connected by a three-stranded hinge. The substrate specificity of this group is not known, but it is predicted to be involved in the transport of sugar-containing molecules and chemotaxis.	6.61196e-110
NC_016935.1|WP_014371869.1|6983284_6984913_-|helix-turn-helix-domain-containing-protein	gnl|CDD|381091	cd17536, REC_YesN-like, phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators. This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	1.25387e-50
NC_016935.1|WP_013919938.1|6959368_6960256_-|carbohydrate-ABC-transporter-permease	gnl|CDD|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	6.00137e-56
NC_016935.1|WP_014371873.1|6992368_6993538_-|mandelate-racemase/muconate-lactonizing-enzyme-family-protein	gnl|CDD|227284	COG4948, COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only].	7.84736e-58
NC_016935.1|WP_013919944.1|6967622_6968108_+|heme-degrading-domain-containing-protein	gnl|CDD|179430	PRK02487, PRK02487, heme-degrading domain-containing protein.	3.66253e-60
NC_016935.1|WP_014371864.1|6976266_6977862_-|diguanylate-cyclase	gnl|CDD|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	5.64795e-59
NC_016935.1|WP_014371871.1|6988784_6989900_-|glycoside-hydrolase-family-88-protein	gnl|CDD|226678	COG4225, COG4225, Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only].	1.5999e-84
NC_016935.1|WP_041619279.1|6960338_6961292_-|ABC-transporter-permease-subunit	gnl|CDD|226666	COG4209, LplB, ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism].	1.49751e-120
NC_016935.1|WP_014652445.1|6973928_6974822_-|ABC-transporter-permease-subunit	gnl|CDD|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	2.7361e-57

Protein sequences

>NC_016935.1|WP_014371864.1|6976266_6977862_-|diguanylate-cyclase
MPGWIPKRLGLIKFQVLLTGLLAFSLAGTTAVLTGVALTKQNDSMTDSILQSNFEGARNLNVSMNKLLDLMMRELGAAAKFIGGQEGPLEQQAGYVNEMLGGRRFFAGAVLLDAKGVVRASTPGLLMQAGEALDEQVVEMALALPRPFVSGAFIAPNGHCAVLVSHPVMNRDGQRLGVVAGVIDLDERNVFSDFFEHASRSKNGTYAYLVNERGQVMLNPDDQRSGELIAPEVLRQTFPNEDIRYAAVRNTEGREVLAGYLTIPKIGWGIVFQSPAEVVDEALGVLIKAQLAWILPLFVLMLLVSLGIARKLAAPFAALTAAARQISAGERMVDPPFTRHWNYEAHHLAKAMMWAVGALQHQADRMSEQARTDGLTGLANRVCLEERVADMETGNQPYALLVLDIDHFKSVNDVYGHQTGDEALVHLARMISLEAGGESFAFRFGGEEFVVLLPGGGLEDGLDLAERIRSRMEHTVSPTGRPITVSIGAAACPRHGETFGEVFERADQALYQAKRSGRNRTAAAEELLPVG
>NC_016935.1|WP_013919948.1|6974848_6975820_-|sugar-ABC-transporter-permease
MNRAFAEPSVPSALTKQNQFTFWRKLRNNRTLLMMCLPAVLFFILFSYLPMPGLYLAFINYNYTDGIFGSEFIGLDNFRFLVESGDLWRLTFNTVAYNLAFILLGNALQIFVAIMLNELRSKFFKKVSQTLMFLPHFISAVLIGLIAYNILSFDYGLLNSILKSMGMEPVKTYSNPGIWPYIIILTYLWQSTGYGSIVYFAAIMGLDSEIVEAAEIDGANGFQRIRYIILPWLKPTFIILLLFSLGGVLRGNFGLFYNLVGANNTMLYSTTDIIETFVFRSLMNNFNFSMGSAVSLYQSLFGFAFVLTANWLVKKFSPDNSLF
>NC_016935.1|WP_014652445.1|6973928_6974822_-|ABC-transporter-permease-subunit
MNVRHTDRSSLIIRIVSYVFIALLAVSCLLPFVLIVATSLTSEASILKNGFNLWPKEFSTYAYRIVFENPELIIGSYIVTLGITLVGTAVGLFLVAMTGYALQRPDFHFRNKISFFIYFTTLFSGGIVPFYLLITQYLHLKDNYLAVLLPGLLSPFLIIMMKSFTQSIPHAITESAKIDGAGDFTIFMRLILPMSTPALATIGLFIALGYWNEWYNSMLFLSPDMKYRPLQLFLYNVVTSADFIRNSAAASNVPLRDVPLESMKMATAVVATGPVILFYPFVQRYFIQGITVGAVKG
>NC_016935.1|WP_014371863.1|6972301_6973882_-|DUF3502-domain-containing-protein
MVTRKIGMTLLSAVMAVSLTACSGGGNSESGKAAPGPAGTADSGQADTSKFETITYVMLGDKPKNGQVEKVLEKINVIMKEKINAKLELKWVEWADWQTKYNLLLASGEPVDLITTATDWLDAWPNAQKGAFLPLDQLLPKYAPETWKEIKPEEWDQTKYKDKIYMIPENSYTQWVNHGFFYRGDWAKEFGITEPIKDFETMGKYFQGIKDKKPDVIPWDSNGTNGEHAKGFIQSKTDAIELAVPTGYLPVVWGKSYDERYTAHSPIFDDTFVDFAKMMKAWADRGYWREDVLNYKGNVRDELKAGQTGADQHHTQTFSGLRTEMDAKQPGSELQMFAWSDTRGNLISQPITHGATAVGAKSKHPERALMAYELIRQNKEVYYLMNYGIEGVQYVIKDGKRAQPEGYDATRDGFSSNFWGGRVDRLEIPSATTWDGIKDIYKKYDGIKKPYPYGRFVLDKSKIDPQLTAMSQVTSQMGPAIAYGKAGDPVKAVEDLRSKLKAAGYDKVMAEVQRQLDEYKKLVESK
>NC_016935.1|WP_014371862.1|6968311_6969307_-|family-43-glycosylhydrolase
MNIYNEASDTAHPKQGLRLSDIPAHDPFVVADRESGTYYLYTGSGPQLHGMKRCGVVTYKSADLRHWEGPYVVFTVPDGVWANPRHGAWAPEVHAYKGSYYLLVTLHNNDRRLPDSPLIPMPNHWRGTAVAVSSSLEGPFELLQPDGPAVHSSLMTLDGTLYIDEEGRPWMVYCHEWIQMRDGTVEAVPLRADLSRAAGEPVHLFQASEASWDTAERTPGVEGSIYVTDGCQLYRTRGGHLVMLWSSYDQGQYVQTQARSVSGSLKGPWEQLEPLVRGDSGHGMLFRTFEGTWMLILHQPFPMPDSRCKLYEMEDAGDRFRVVAAREDLHG
>NC_016935.1|WP_013919944.1|6967622_6968108_+|heme-degrading-domain-containing-protein
MLELERKVKEMEEQERVFQFEEFTHETALELGLLLVQEAKRSGVRVTVDITRSGQRLFLHAMEGTTVGNEDWIRRKNNLTGRFGRSSWHTAMRLRLQGEELERDYGLPVKDYAAAGGSFPLHVKGEGILGTITVSGLPDQEDHDLVIGALQKYFDGLRQPE
>NC_016935.1|WP_014371861.1|6966334_6967402_-|LacI-family-DNA-binding-transcriptional-regulator
MAKKVTMQQIADYMGVSKFVVSKALSGKGGVSEATKEKVIKAASQLGYFSKMNPYLPPKPAESTQDGGTKQSVLVLMPNVRFQTKESVYWGRILDGISARLEAAGLGMMIVMEQSADHFLQALNPSGILGLIGVGEISSSVLLEVHRLGVPFILVDHEDGLIPSDTVFVNNYDSMHRLTNYLIGIGHKHLLFVGDPRYSRSFYDRWTGFRSAVEEQGLAPDSPASLLIRLEGYEGFTTQIQEAVEALRRKALPTALVCANDTIALDTIEVLQRMGIKVPQEVSVTGFDNIERSYQTSPSLTTVNVPKELMGSRAVEKLLERVSKDQDATEKLLIAGEVMYRESSAGAAKTAEAEV
>NC_016935.1|WP_013919942.1|6965520_6966198_+|cupin-domain-containing-protein
MPMTPDPDFSSPSAQFFFDLSQDLYFRKDARNFINRLSVKDLNTLGGVSLLDIYLDTGNVVEPHIHQNASELVYVITGSAVISLINPFTNELLNYTAGPGQVVNIPQGWWHYEVASADGTHLLAIFDSKVPEAIFGSDILRLTPSGVWAHTYGLDQAQVAAAFAPITGTTIIGPPLPGQQTTKPMPYVPYGSPRQPVYAEQAAHYQRPAYPAPYLAQGYGWPYPY
>NC_016935.1|WP_041619279.1|6960338_6961292_-|ABC-transporter-permease-subunit
MHAPKRAEQREPGVWQRFAQQWDYQSMILPSILFLIIFSYIPMWGVLLAFKEYDLFAGFAASPWVGTLHFRMFFESPEFWLIMRNTICISLLKLAVGFPAPIVLALMLNEVANMAFKRVVQTITYIPHFISWVVVSGLVFSMLAVDGGAVNGLLLQLSLIDRPVNWLSVPEYFWAILVSAGVWKEIGFGSIVYLAAIAGIDPALYEAASLDGASRFKQIFLITIPSIAPVIIIFLILGVGNILHAGFEDILLLTQNLNNGILMPYAEVIDTYVYQMGIINQRYSYATATGLFKSVISVLLLLIANYTARKLGKASLW
>NC_016935.1|WP_013919938.1|6959368_6960256_-|carbohydrate-ABC-transporter-permease
MKLNVYDRTLRAAIYVLLVLLSFLTFYPFWNSLVISFNTGSDTSLGGVTFWPREFTLENYRIVFQEDAIFQAYLITILRTAAGTVLSMFFTALFAYGLSKRGIVFKKFYMILCVITMYFSGGLIPYFVLVYQMKLYDTFAFLVIHGMISVYNMIIFRTFFAELPDGLEESARIDGCSNYGVFFRIVLPVSGPVVATLSLFTAVGLWNDWFTPAVFINDPNLIPLQTMLVQIINAGTTATLVSNLNSYAQSMVQNTVTVKALQMATMMVATLPILLVYPFLQKYFVKGALVGSLKE
>NC_016935.1|WP_014371866.1|6979746_6980382_+|TetR/AcrR-family-transcriptional-regulator
MRKPGSVDQYIERIKPVVRKTRFSQLKIDEVAKVMDISKATLYKYFSSGEDIISTIVDHYTDYMLQADTLVQEDSVPYPERFQRLYGHSLRCVIYGSNLFMQDLQENYPPLYDKLAAAQQVRNKNLTPFYESGMEKKIFNPMNPILFMIQDEAVLRSIVEPLFCVQYDLTLKQALLDFYTLKKFQLLTPEHLQAVDDSIIENEIVQLLQSL
>NC_016935.1|WP_014371867.1|6980466_6981483_-|substrate-binding-domain-containing-protein
MNKGWGVVLAVLLLLAAGLGYYGWTSGADAKSRPILLIPKTTDPRISFWQAMRQGAEAAAREYGVEVQMAGMAAETEIEGQIRLLEEAILRKPRAIILAAADSNRLLPVCTRIKEAGIPLITVDSGLSAEAAASLIATDNYAAGRQVGDAMGALLKPGAKVAVISFVKGSTPAVERERGVRDSLEEKGITVAQTLYTNAEEELAYRLTTELLQTAAASELDGFIGLNEPSTVGAARALKEGQPEGGRVPMVGFDSSMREIAFLEEGVLQAIVVQKPFNMGYLAVKTAVEASSGVAAAPWVDTGAVTVTRSTMFSKANQKLLFPFGSEAYGGLVGESRE
>NC_016935.1|WP_014371868.1|6981479_6983288_-|sensor-histidine-kinase
MRGVRLFQYQSIHTQIALAFSALILCTTIILSYTAYRLSSDAVTGTSLEYTKELVRQVHTNVENYIYSMESIASLALSSGELKRYASLPRQDSEEGEELGRRLGDYFRSVLASRKDMASILFVGGHGGMVGGRSGESLKPSSEVRQQEWYLNAHQLEGGTAITSSHVQQLYRGEYPWVVSISKALPSTAAKPSGEGADGGVLLVDLNYSVIDNLCKQIQLGRRGYVFILAPSGDLVYHPQQQILNTQLKTERIPDILESRDGTMTFGRGAEQKIYTVSTTRFGWKVVGVVYPEDLARNKRAMQGSAALWGSLCLAVALSISVILSFRLTRPIKALEGHMKLAEKGDFGQRVEIESTNEIGKLARTFNVMIGRIQDLMEQIVQEQEQKRISELKALQAQIKPHFLYNTLDSIIWMAETRKVDEVVTMTSALAKLLRSSINQGEEWVPLAVELEQIRHYLTIQQIRYRRKFTYSIEVPEELYPYPIVKLVLQPIVENAIYHGIKHKAEPGHIRISGRRGAGGIELAVSDDGVGMTPEKLQTILGGTPRTKEAPGGSGVGVHNVHQRIALAFGPGYGLGFESELEEGTTVTIRLPELEDKGGSAG
>NC_016935.1|WP_014371869.1|6983284_6984913_-|helix-turn-helix-domain-containing-protein
MYSLMLVDDEDEVREGIMEKTDWVACGFRLAGAYENGRDAAEALEALRPDVLITDICMPFMDGLELSRYAAEISRDTKIVIITGYEEFDYAKEAIKLRVNEYLLKPINAREFMAFLGRLKTELDEQRASRENLSVIRQQLNQSLPLLKERFLERLSASVMKREELHRKLEYFGLTLPGPAFVSMVADIDPRQNPQAAGGAADAGSDLELLHFAVFNIFQEIFEKENGGAVFRTRDDRIGVLLCGLPESIGPLAQNLAAHAAYSVEKYLKLTLTIGIGRHCTALTQVPRSFREAGSALDYRLLLGSNRILCISDLEQGTSLHSMEYLEWEKKLLSALKMGKGSQVSSVLSAWLEEWRSAGLPVEKCYGMLYKFVVALMNWVAETGCGEAEVFGEDPFREMRALRTLDQLKQWLEGLCHRVICTLGERRSLATQSQMHLAEAYIKEHYVSESLSLQQVCDHIYMSASYFSACFKQHTGLTFVEYLTRLRIDKAKELLAATALKAYDIASRVGYPDPQYFSVIFKRHTGRTPKEFRLLAAAGETV
>NC_016935.1|WP_013919955.1|6985041_6986064_-|ABC-transporter-substrate-binding-protein
MAKKKSWFALAGVTVMAAALLGACGGNGGGSQQANAPASSEASKAGDSQAAGKVYIPVISKGFQHQFWQAVKQGAEKAAKEYQVEITFEGPESETQVDKQIEMLQAALGKKPQAVALAALDSKAVAPLLQKAKAQNIPVVGFDSGVESDVPVTTAATDNKAAAALAADKMAELIGQEGEIALIVHDQTSRTGVDRRDGFVNRIKEKYPKIRIVDVQYGGGDHLKSTDLAKAILQAHPGVKGFFGANEGSAIGVLNAAAELKKEKLVIIGFDSGKQQIEAIRSGRMAGAITQDPIGIGYWSVKAAAMAVKGESVPKTIDTGFHWYDKSNMDSDTIKPLLYN
>NC_016935.1|WP_013919956.1|6986100_6987090_-|ABC-transporter-permease
MKVVSLNRQPSIRTGAMQKVLAFASLILLVVVFSLASSNFFRFDNLVAIILSTAVIGVLALGSTFVIITSGIDLSVGTVMTFASVMTGVIITTWQLPMPLGIIGGILTGAVCGLLSGLAVAKLKIPPFIATLAMMMITKGLSLVISGTKPIYFNDAPLFMDIAMGSVIGAVVPGFDIPNAVLIFFGLAVIASIILSKTIIGRFTFALGSNEEATRLSGVNVDKWKIIIYTITGAFSGIAGILMASRLNSAQPALGAGYELEAIAAVVIGGTSLSGGQGSILGTVIGALIMSVLTNGLRILSVPQEWQTVIVGLVVILAVYADMLRRRKK
>NC_016935.1|WP_014371870.1|6987102_6988593_-|sugar-ABC-transporter-ATP-binding-protein
MGEPLISMEGIVKRFPGVLALDGCRFELHAGEVHALVGENGAGKSTLMKILTGVYAKDEGRIRYEGREVEIPNTKAAQEMGISIIHQELNMMPHLTVAQNIFIGREPRRGWFLDEKALHRRTQELFARLHLQLDPGTPVSELTVAKQQMVEIAKALSFDSKVLIMDEPTAALTQSEIEELFRIIEQLRSQGVGIVYISHRMEELKRITDRITVMRDGCYIDTVRTESITIDQIIAMMVGRQIRHLSRPSAAENRNPVVLEVRDLSRGTQLRNISFHLRQGEILGFAGLMGAGRTEAARAIFGADPVDRGEIRIHGRPVSIKQPHDAVAQGLGYLSEDRKQFGLLTEMDVKTNIAVASYAGCARWGWMDDKRIAQTAERYVQSLKIKTPGTGQPVKFLSGGNQQKVVISKWLTRDCDILIFDEPTRGIDVGAKSEIYALLEQLAEEGKSIIMISSELPEILRLSHRILVMCEGRITGELSSGEATQERIMRLATMRT
>NC_016935.1|WP_014371871.1|6988784_6989900_-|glycoside-hydrolase-family-88-protein
MEYGLVDKMKAQYRAEPKWYSVRWHYIEGCILKAYLDSWAQTGSEEDYQFVKGFIDRLYDEEGNISAVNPAYYNIDQIRMATVLFPLYERERDPKYKRVMDLLYGQLSHYPRTNSGAFWHKSNYPHQVWLDGLYMGQPFYVQYTKQFAEPKEYSDTLAQFRNVRKNIYNEKKRLYSHAYDESRQMFWSDPVTGQSPNVWGRAVGWYVMALVDVLELLEGEEADAGFLQQDLQDTIDDMLRHQHSEGMWYQVVDRADHPDNYLESSGTLMMAYAILKGVRLGFLPGEYAGHGKKAFDGTVSRYVREEEGEVLLGGICRSAGLGTHPDTGAVRDGSVDYYLHSEKIVDNNGHGAAPLLMAYNEIKRLLNQAAS
>NC_016935.1|WP_014371872.1|6989984_6992261_-|helix-turn-helix-domain-containing-protein
MPRYLYRLLVFTLLLVAAPVVSIGMISYYIASKDTEQKVNEGNTHMLLQNQMRIEQVLKHVEMGAVQYVSSSLVTDHLYDDLTPDDFVTITDLAKGLYNLHSLSGVADTHLVNLEHDWMISNLGFTKVRDYLEPDLLSEYSSNPKNLFWLAGGTGKKRGGSTEEEAPARETVRMVVKLPMIAPSSEPKALLIIDMDEQKLESDMTPNEQWGNMYVVSREGLPFLTNPGSVDLTDSILLHLKTLTNSGGYFEADGMAVNYRVSPYNHWTYASVNSIESMTKESKKIAVITLNACLIIFVIIAAGAYYGSRRMYSPFRRLFLMMERYGGEAAVSRQQDEFAYIEDRFNSLFRTRKQLQTQLQGQRGQMREFFVLKLLMGQITESEFTYKSETYGFAGKGRSMGVLTLQIDALHETRFTENDKELLLFAINNMVGELIPSSGLLGNVLLDQSQISILISDSDDPDACKAFLHQTAAWIKTRVYELLQLKVSIGISRSFTRYTDANHAYTEALEALKRRISLGNDIILHYDDMKLGSGQRSSACVSLEHFEDDVIHALKVGDSVSTAGHYDRYVEAIMEKEIGFNDFQMVMLQLVNRVYRLVNEQEGSLHSLVRNQSILNRFVKLHTASEMTAWFKQEFLPPILEYMRERVDRQYINIAHEMVQLIHEQYGRDLTLETCAERLKYHPVYLSRVFKKEIGVTFIDYLTDYRMKMAKSWLENTDLKITEIAGRLNYTNATGFIRTFRKLTGMTPGQYRDSHSSG
>NC_016935.1|WP_014371873.1|6992368_6993538_-|mandelate-racemase/muconate-lactonizing-enzyme-family-protein
MKITDIRLTVVGMPRHTGFVSKHVIVEIDADNGLTGIGEMSDFSHLPYYSLDIHDLLTVLKSALLGTNPFDISLSNKVLGSYYPEAMFYYEKGNFIRNGIDTALHDLCAKALGISVSELLGGRIREKIKVCFPIFRHRFMEEVEENVAVVRRRLAQGFDTFRLYVGKNLDADEAFMDRVRTEFGSRVTIKSLDFSHLLEWKLALQAAKRFRQYDFQLIESPAVQNDFEGLRHFRLKADHPVSEHVWSFRQQFEMIRQDSVDIFNISPIFIGGLTSARKAAAAAEVAGKSCLIGTTQELSVGTASMAHLGSALVNLNYTSDPTGPELYVGDIVKHPVQYQDGYLLVPGRDQPGLGVELDWERIGKYRVDDLSWGNISVHQLQDRTAQTKA

Crispr_ID: NC_016935_17

• CRISPR_ID: NC_016935_17
• CRISPR_location: 7271838-7272389
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 7 spacers

Consensus repeat of NC_016935_17

Consensus_repeat	Method
CACCGACTCNGNNGCCAGCTTCTCCGCCGTCACCGACTCNGC	CRT

spacers of NC_016935_17

>17.1|7271880|18|NC_016935|CRT
CCCGAGCTTCTCCGCCGT
>17.2|7271940|48|NC_016935|CRT
CGCCAGTCTCTCCGCCGTCACGGACCCCGGGGCGAGTTTCTCCGCCGT
>17.3|7272030|48|NC_016935|CRT
CGCCAGCTTCTCTGCCGTTACGGATTCCGCCCCGAGCTTCTCTGCCGT
>17.4|7272120|48|NC_016935|CRT
GGCCAGCTTCTCCGTCGTTACCGACTCATCGGCCAGCTTCTCCGCCGT
>17.5|7272210|18|NC_016935|CRT
CGCCAGCTTCTCTGCCGT
>17.6|7272270|18|NC_016935|CRT
TCCAAGCTTCACTCTTGT
>17.7|7272330|18|NC_016935|CRT
CGCCAGCTTCTCCGCCGT

CRISPR arrays and Neighbor proteins around NC_016935_17

CRISPR arrays

The CRISPR arrays of NC_016935_17

>merge|NC_016935|17|7271838-7272389|CRT
GACCGCGCCGGACGCCAGCTTCTCCGCCGTCACCGACCTTACCCCGAGCTTCTCCGCCGTCACCGATTTGGACGCCAGCTTTTCCGTCGTCACCGCTTCCGCCGCCAGTCTCTCCGCCGTCACGGACCCCGGGGCGAGTTTCTCCGCCGTCACCGTCTCCGATGCCAGCTTCTCCGCCGTCACCGACTCTGCCGCCAGCTTCTCTGCCGTTACGGATTCCGCCCCGAGCTTCTCTGCCGTCACCGACTCCGAGGCCAGCTTCTCCGCCGTCACCGACTCCGAGGCCAGCTTCTCCGTCGTTACCGACTCATCGGCCAGCTTCTCCGCCGTCACCGACTCCGCTCCCAGCTTCTCCGCCGTCACCGACTCGGCCGCCAGCTTCTCTGCCGTCACCGACTCCGACGCCAGCTTCTCCGCCGTCACCGACTCCGCTCCAAGCTTCACTCTTGTTACCGACTCGGCCGCCAGCTTCTCCGCCGTCACCGAGTCCGCCGCCAGCTTCTCCGCCGTCACCGACTCCGCCGCCAGCTTCTGCGCCGTCACCGACTCCGC

>NC_016935|17|5|7271838-7272389|CRT
GACCGCGCCGGACGCCAGCTTCTCCGCCGTCACCGACCTTAC	CCCGAGCTTCTCCGCCGT
CACCGATTTGGACGCCAGCTTTTCCGTCGTCACCGCTTCCGC	CGCCAGTCTCTCCGCCGTCACGGACCCCGGGGCGAGTTTCTCCGCCGT
CACCGTCTCCGATGCCAGCTTCTCCGCCGTCACCGACTCTGC	CGCCAGCTTCTCTGCCGTTACGGATTCCGCCCCGAGCTTCTCTGCCGT
CACCGACTCCGAGGCCAGCTTCTCCGCCGTCACCGACTCCGA	GGCCAGCTTCTCCGTCGTTACCGACTCATCGGCCAGCTTCTCCGCCGT
CACCGACTCCGCTCCCAGCTTCTCCGCCGTCACCGACTCGGC	CGCCAGCTTCTCTGCCGT
CACCGACTCCGACGCCAGCTTCTCCGCCGTCACCGACTCCGC	TCCAAGCTTCACTCTTGT
TACCGACTCGGCCGCCAGCTTCTCCGCCGTCACCGAGTCCGC	CGCCAGCTTCTCCGCCGT
CACCGACTCCGCCGCCAGCTTCTGCGCCGTCACCGACTCCGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016935.1|WP_041619301.1|7273606_7274833_-|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_014371996.1|7258862_7259591_-|glycosyltransferase-family-2-protein	unknown	unknown	gnl|CDD|133029
NC_016935.1|WP_014371999.1|7262071_7263448_+|glycosyltransferase	unknown	unknown	gnl|CDD|223515
NC_016935.1|WP_014372003.1|7267373_7267829_-|dTDP-4-dehydrorhamnose-3,5-epimerase-family-protein	unknown	unknown	gnl|CDD|224810
NC_016935.1|WP_014372009.1|7277314_7278214_+|EcsC-family-protein	unknown	unknown	gnl|CDD|378945
NC_016935.1|WP_014372015.1|7285196_7286846_-|b(o/a)3-type-cytochrome-c-oxidase-subunit-1	unknown	unknown	gnl|CDD|238830
NC_016935.1|WP_041618516.1|7266053_7267004_-|GDP-mannose-4,6-dehydratase	unknown	unknown	gnl|CDD|187570
NC_016935.1|WP_014372013.1|7281563_7283207_-|S-layer-protein	unknown	unknown	gnl|CDD|377924
NC_016935.1|WP_014372010.1|7278194_7278533_+|cupin-domain-containing-protein	unknown	unknown	gnl|CDD|369571
NC_016935.1|WP_014372007.1|7275096_7276299_-|glycosyltransferase-family-4-protein	unknown	unknown	gnl|CDD|340831
NC_016935.1|WP_013920221.1|7283541_7284015_+|MarR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|197670
NC_016935.1|WP_013920224.1|7286873_7287344_-|cytochrome-c-oxidase-subunit-II	unknown	unknown	gnl|CDD|259980
NC_016935.1|WP_014372008.1|7276527_7277100_-|DNA-3-methyladenine-glycosylase-I	unknown	unknown	gnl|CDD|377025
NC_016935.1|WP_014372005.1|7268731_7269706_-|dTDP-glucose-4,6-dehydratase	unknown	unknown	gnl|CDD|187557
NC_016935.1|WP_014372004.1|7267788_7268718_-|dTDP-4-dehydrorhamnose-reductase	unknown	unknown	gnl|CDD|224016
NC_016935.1|WP_014372000.1|7263591_7264233_-|hypothetical-protein	unknown	unknown	gnl|CDD|370127
NC_016935.1|WP_014372006.1|7269718_7270438_-|NTP-transferase-domain-containing-protein	unknown	unknown	gnl|CDD|133019
NC_016935.1|WP_014372001.1|7264599_7266036_-|glycosyltransferase	unknown	unknown	gnl|CDD|340831
NC_016935.1|WP_014372014.1|7284143_7284920_+|pirin-family-protein	unknown	unknown	gnl|CDD|224655
NC_016935.1|WP_014371998.1|7260970_7261750_-|glycosyltransferase	unknown	unknown	gnl|CDD|275103

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016935.1|WP_014371996.1|7258862_7259591_-|glycosyltransferase-family-2-protein	gnl|CDD|133029	cd04186, GT_2_like_c, Subfamily of Glycosyltransferase Family GT2 of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.	2.3829e-52
NC_016935.1|WP_014371999.1|7262071_7263448_+|glycosyltransferase	gnl|CDD|223515	COG0438, RfaG, Glycosyltransferase [Cell envelope biogenesis, outer membrane].	7.4322e-17
NC_016935.1|WP_014372003.1|7267373_7267829_-|dTDP-4-dehydrorhamnose-3,5-epimerase-family-protein	gnl|CDD|224810	COG1898, RfbC, dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane].	2.94497e-51
NC_016935.1|WP_014372009.1|7277314_7278214_+|EcsC-family-protein	gnl|CDD|378945	pfam12787, EcsC, EcsC protein family. Proteins in this family are related to EcsC from B. subtilis. This protein is found in an operon with EcsA and EcsB which are components of an ABC transport system. The function of this protein is unknown.	4.40749e-100
NC_016935.1|WP_014372015.1|7285196_7286846_-|b(o/a)3-type-cytochrome-c-oxidase-subunit-1	gnl|CDD|238830	cd01660, ba3-like_Oxidase_I, ba3-like heme-copper oxidase subunit I. The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea which catalyze the reduction of O2 and simultaneously pump protons across the membrane. It has been proposed that Archaea acquired heme-copper oxidases through gene transfer from Gram-positive bacteria. The ba3 family contains oxidases that lack the conserved residues that form the D- and K-pathways in CcO and ubiquinol oxidase. Instead they contain a potential alternative K-pathway. Additional proton channels have been proposed for this family of oxidases but none have been identified definitively. For general information on the heme-copper oxidase superfamily, please see cd00919.	0
NC_016935.1|WP_041618516.1|7266053_7267004_-|GDP-mannose-4,6-dehydratase	gnl|CDD|187570	cd05260, GDP_MD_SDR_e, GDP-mannose 4,6 dehydratase, extended (e) SDRs. GDP-mannose 4,6 dehydratase, a homodimeric SDR, catalyzes the NADP(H)-dependent conversion of GDP-(D)-mannose to GDP-4-keto, 6-deoxy-(D)-mannose in the fucose biosynthesis pathway. These proteins have the canonical active site triad and NAD-binding pattern, however the active site Asn is often missing and may be substituted with Asp. A Glu residue has been identified as an important active site base. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	6.38765e-141
NC_016935.1|WP_014372013.1|7281563_7283207_-|S-layer-protein	gnl|CDD|377924	pfam07833, Cu_amine_oxidN1, Copper amine oxidase N-terminal domain. Copper amine oxidases catalyze the oxidative deamination of primary amines to the corresponding aldehydes, while reducing molecular oxygen to hydrogen peroxide. These enzymes are dimers of identical subunits, each comprising four domains. The N-terminal domain, which is absent in some amine oxidases, consists of a five-stranded antiparallel beta sheet twisted around an alpha helix. The D1 domains from the two subunits comprise the 'stalk' of the mushroom-shaped dimer, and interact with each other but do not pack tightly against each other.	3.02918e-21
NC_016935.1|WP_014372010.1|7278194_7278533_+|cupin-domain-containing-protein	gnl|CDD|369571	pfam07883, Cupin_2, Cupin domain. This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel).	3.33711e-14
NC_016935.1|WP_014372007.1|7275096_7276299_-|glycosyltransferase-family-4-protein	gnl|CDD|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	3.96978e-66
NC_016935.1|WP_013920221.1|7283541_7284015_+|MarR-family-transcriptional-regulator	gnl|CDD|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	2.74607e-26
NC_016935.1|WP_013920224.1|7286873_7287344_-|cytochrome-c-oxidase-subunit-II	gnl|CDD|259980	cd13913, ba3_CcO_II_C, C-terminal cupredoxin domain of Ba3-like heme-copper oxidase subunit II. The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea, which catalyze the reduction of O2 and simultaneously pump protons across the membrane. It has been proposed that archaea acquired heme-copper oxidases through gene transfer from gram-positive bacteria. The ba3 family contains oxidases that lack the conserved residues that form the D- and K-pathways in CcO and ubiquinol oxidase. Instead, they contain a potential alternative K-pathway. Additional proton channels have been proposed for this family of oxidases but none have been identified definitively.	2.10157e-53
NC_016935.1|WP_014372008.1|7276527_7277100_-|DNA-3-methyladenine-glycosylase-I	gnl|CDD|377025	pfam03352, Adenine_glyco, Methyladenine glycosylase. The DNA-3-methyladenine glycosylase I is constitutively expressed and is specific for the alkylated 3-methyladenine DNA.	1.59991e-131
NC_016935.1|WP_014372005.1|7268731_7269706_-|dTDP-glucose-4,6-dehydratase	gnl|CDD|187557	cd05246, dTDP_GD_SDR_e, dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs. This subgroup contains dTDP-D-glucose 4,6-dehydratase and related proteins, members of the extended-SDR family, with the characteristic Rossmann fold core region, active site tetrad and NAD(P)-binding motif. dTDP-D-glucose 4,6-dehydratase is closely related to other sugar epimerases of the SDR family. dTDP-D-dlucose 4,6,-dehydratase catalyzes the second of four steps in the dTDP-L-rhamnose pathway (the dehydration of dTDP-D-glucose to dTDP-4-keto-6-deoxy-D-glucose) in the synthesis of L-rhamnose, a cell wall component of some pathogenic bacteria. In many gram negative bacteria, L-rhamnose is an important constituent of lipopoylsaccharide O-antigen. The larger N-terminal portion of dTDP-D-Glucose 4,6-dehydratase forms a Rossmann fold NAD-binding domain, while the C-terminus binds the sugar substrate. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	0
NC_016935.1|WP_014372004.1|7267788_7268718_-|dTDP-4-dehydrorhamnose-reductase	gnl|CDD|224016	COG1091, RfbD, dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane].	4.10988e-113
NC_016935.1|WP_014372000.1|7263591_7264233_-|hypothetical-protein	gnl|CDD|370127	pfam08795, DUF1796, Putative papain-like cysteine peptidase (DUF1796).	1.1942e-14
NC_016935.1|WP_014372006.1|7269718_7270438_-|NTP-transferase-domain-containing-protein	gnl|CDD|133019	cd02538, G1P_TT_short, G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase. This family is the short form of glucose-1-phosphate thymidylyltransferase. Glucose-1-phosphate thymidylyltransferase catalyses the formation of dTDP-glucose, from dTTP and glucose 1-phosphate. It is the first enzyme in the biosynthesis of dTDP-L-rhamnose, a cell wall constituent and a feedback inhibitor of the enzyme.There are two forms of Glucose-1-phosphate thymidylyltransferase in bacteria and archeae; short form and long form. The homotetrameric, feedback inhibited short form is found in numerous bacterial species that produce dTDP-L-rhamnose. The long form, which has an extra 50 amino acids c-terminal, is found in many species for which it serves as a sugar-activating enzyme for antibiotic biosynthesis and or other, unknown pathways, and in which dTDP-L-rhamnose is not necessarily produced.	9.99744e-109
NC_016935.1|WP_014372001.1|7264599_7266036_-|glycosyltransferase	gnl|CDD|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	8.47318e-19
NC_016935.1|WP_014372014.1|7284143_7284920_+|pirin-family-protein	gnl|CDD|224655	COG1741, COG1741, Pirin-related protein [General function prediction only].	2.31964e-24
NC_016935.1|WP_014371998.1|7260970_7261750_-|glycosyltransferase	gnl|CDD|275103	TIGR04283, glycosyl_transferase_family_2, transferase 2, rSAM/selenodomain-associated. This enzyme may transfer a nucleotide, or it sugar moiety, as part of a biosynthetic pathway. Other proposed members of the pathway include another transferase (TIGR04282), a phosphoesterase, and a radical SAM enzyme (TIGR04167) whose C-terminal domain (pfam12345) frequently contains a selenocysteine. [Unknown function, Enzymes of unknown specificity].	1.02601e-14

Protein sequences

>NC_016935.1|WP_014372006.1|7269718_7270438_-|NTP-transferase-domain-containing-protein
MKGVIVAGGSGTRLRPLTDLVNKHLLPVGGYPMIHYALAKMAEAGIREVLLITGKASAGLFTQYIGSGEPWEIQVTYRIQERPGGIAEAVSLAEGFIRPGDKFVVLLGDNLFEDSLAAAVSEFQEQPTGARVFLKEVPDPRRYGVPVLRDGRIVSIEEKPENPPSTYCVTGIYMYDAGVFGEIRQVTRSARGELEITDVNNRYAAAGLLQYGMLEGWWADAGTPRSLLEAGLRLMKGES
>NC_016935.1|WP_014372005.1|7268731_7269706_-|dTDP-glucose-4,6-dehydratase
MVTGGMGFIGSNFIRYWLERHPEDTVLNLDLLTYAGREENLADVVRDPRYALSVGDIADPMVFRLLEEEKIDTVVHFAAESHVDQSILDPQRFVRTNVLGTQNLLEAARRTGVKKFVHISTDEVYGTLGSTGAFTEETPLAPNSPYSASKAGSDLLVRAYCETYGFPAVITRCSNNYGPYQFPEKLIPKIITRALRGEDIPVYGDGLYVRDWLHVEDHCSGIERVILQGRQGEVYNIGGGNERTNLSMVRLILEELGRPLSLIRHVEDRPGHDRRYAIDALKIRRELGWQPLRSLEEGLKTTVQWYVEHQDWWEPLLAGGGQQE
>NC_016935.1|WP_014372004.1|7267788_7268718_-|dTDP-4-dehydrorhamnose-reductase
MKIGITGAGGQLGQDLIRMLESRHELVAWKHQDLNITDEKAVEQAFALHRPDAVIHAAAFTGVDAAEKNLDAAYMVNAFGTRHVAWAAHTIGAKMVYVSTDYVFDGRKGEPYTEGDRTAPLGIYGNSKLLGEKFTEFLCDRHFIVRTSWLYGLSGSNFVTKVLQLAKEQGSLRMVSDQYGSPTYTLDLAAQIAELIETEEYGVYHVSNRGFCSRLRFAEAILEIAGLAGVRLEAVESAELSLPAERPVHSGLSDLALRRRGFGRMRHWKSALEAFIREDLKCGGLEHNEDGEEGPKDDSKRADQDADPA
>NC_016935.1|WP_014372003.1|7267373_7267829_-|dTDP-4-dehydrorhamnose-3,5-epimerase-family-protein
MIRNVLTKTLIRHSDDRGFFMELLREDDEIFNGFGQASLSLSYPGVIKAFHYHAQQDDIWYFPSGQAQVVLHDLRPDSPTYKQTDVYYMGELSPYLLFIPRGVAHGYRVLGHLPATIVYFTNKAYDPADPDEFRLAYNDPDIGFNWQTRFR
>NC_016935.1|WP_041618516.1|7266053_7267004_-|GDP-mannose-4,6-dehydratase
MKTLITGISGFAGSHLAEYLLKQGVEVIGTIRGRSPMNHIRHLLGRIRLVECELRDPISVDTLIREERPERIFHLAAQSFVPASWNSPIDTICNNVAGEVHLFEAVRSHGVDCRIQIACSSEEYGHVNPDEVPIKETNPIRPLSPYAISKVAQDYLGYQYYRSCGLHTVMTRTFNHTGPRRGESFVTSSLAKQIADIEKGKKDPVIHVGNLQAKRDFTDVRDVVRAYWLALEKGGAGETYNIASGTCCAIEEVLQKLLSFSTVQIRIEEDPARLRPSDVEILLGDYTKFHRKTGWKPEIPFERTLEDLLNYWRSQP
>NC_016935.1|WP_014372001.1|7264599_7266036_-|glycosyltransferase
MMLITAVKTVKKRKRRGKAASWKLKRGKGSTARRKKKKLPGTPAKGKKRRRKRSLHARGRKGAGKRGRMRLRKRVKKRRRRIKHRIEPAPLQIAVQEEHPPAEAPAQTTEEVPQLLPGAALIGYARGEFGLGESLRLAAGAMEAAGIPFGIIDYPLSGPSRDTSWIHKESTAMYRTNIFHVNADSMGPVWQFVSGRTKGRYNIGYWHWELPDLREADLQAFDYVDEVWTPTAFVQESVKKRSPVPVMRIPHGIHVPVQPEWGRAAFALPADRFLFMSMFDVHSSTRRKNPHAVISAFKEAFGPDDRNVGLVLKVKGRDSGIDDLHTLYRLLEGYRNIYLIERVLSRLEVNSLLNSVDCFVSLHRSEGFGLGLAEAMYLGKPVIGTNWSGNTDFMRPDNACPVDYRLVPVGESWGPYDAGQIWAEPDTRHAAAYMRELVSHPGYRARIAANGQQTIRSEFSPRSVGEQIRARLSELGLL
>NC_016935.1|WP_014372000.1|7263591_7264233_-|hypothetical-protein
MRLAELRRPYDYCISLGNNCMPAMELEKKGLKRETLPLDWVISRSTTRVAELLLYRFPNYMQLPNLVIRCPDPKLGTYVVEDLVNGIESYHDFALFLNTSSSLPEYPVFRVRLERRIERLYRILQEKRDLLFIRTGEVTPEEGRLLKGVIEQITGPGKTAHLLIINNHPRLALPRELDWGIPGVCTVEIPYSQTQAERNRAFFGGLLEGISVR
>NC_016935.1|WP_014371999.1|7262071_7263448_+|glycosyltransferase
MKTLRRPLLHQDVKRPKRTRRRKRRLRRLPAAPKTRSTVRKNSRLRQAAVKRRRVKKPGSRRSPAKPRLLRRPAVRSTEAAAVRIPYTGAPGINLIGYNRAEMGLGEGCRLLALALESCGMPYGINNFERGNPSRMGDLSWAHREQEGHPYRVNLFHVNGDNMRYVREEFGDAFMKERYNIGYWAWELSELPDSWRDGFTGLQEIWTPTTFVRDVLARHTALPVRAMPYGIRIPGTFDRAALRARFGLPPASFLFLSMFDVFSTSLRKNPSGAIEAFRRAFPSGSSGAALVVKINNAEAKPEEVEKLRTAVEGCPNILLLPERLTRQEVYGLLAACDSFVSLHRSEGFGLVLAEAMYLGKPVIATDWSGNTDFMNGENSIPVRFELQPVGQDAGPYTSAQVWAEPDLEHAADGMRRAAADLPWSTALGCRGQMTIRSRFSPEASGLAVRQRLQELSLL
>NC_016935.1|WP_014371998.1|7260970_7261750_-|glycosyltransferase
MKKRRRLRRHAAHRNPVSPQVSVIIPVLNERRTLARVIRQAYRVHPQTEVIVVSNGTVDGSDRTAARLGARVISYKQALGHDVGRSIGAKAAQGSVLLFLDGDMVIPAAKLRPYVQAVQQGVDVALNRYSGPAKSKRTHRVVLAKYALNVLLNKGELEGASMTTVPHAISRKALETIGAEALAVPPKAQAIASARGLRIKAVHLLSVGRLNPIRRSRKGGDPVGDLIIGDHLEAVEWLTRETGARGLRTDLGRKREFVR
>NC_016935.1|WP_014371996.1|7258862_7259591_-|glycosyltransferase-family-2-protein
MQKASIVIPHKDGLPLLVRCIDSIRRHTETPYEIIVVDNGSRDGSVEYCLQAGVRLISSPSNRGFPAACNLGMQLAGGDAVLLLNNDVVVAPRWLTNLMRCLYASEDMGLVGPVTNYASGVQMVDTPYNTPEQADSVPNEPDPAKWQEVRRLIGFCLLFKRETMERIGLLDEAYSPGHFEDDDYCYRARAAGYRLMAAGDTFVYHQGSASFGQEPQEGVKELIRRNREIFMAKWGVDPQQFI
>NC_016935.1|WP_041619301.1|7273606_7274833_-|hypothetical-protein
MKKDSRRPAGSKSKPRKQRIASYINELSWLDEKPGKQVIREEASVSQIHPPEETLIEPDPLTEEEEWDVLPKAAPSLKRYTISRPPAAESLSKPYTPAPQPHTPAPQPEIKKTFQGATVYTDDLGEESVTTEKIARYAVDSTRIRRGGVSRENLADYAVDSAKLADRSVTVQKLAPRSVTEDILASGAVTSEKVRDRSISGDKLLDNSISSEKLADKSIDAMKIADGSIHAKHLADEAISGEMIQHQSITSDKIRSGAIQASQLANGSVNTAKLADGAVSTEKLRDGAVTASKIVDGEITTEKLADGAVTEEKLGHWSVASGHLKPNTISHDHLAPGSVRALNIGSKQIESNHLAEEAVQSLHLRDGSVTSGKLAKHAVQGTHLSESIVEGKHVQAGGIEGRHLPPMP
>NC_016935.1|WP_014372007.1|7275096_7276299_-|glycosyltransferase-family-4-protein
MKPRIDVAVVTPGSFVIPSGKSSSVELVVEEVAARVGRRVRVAVLGRRSRVLPPEELRGGVKYARVPAPTPAGYIRNVSRRLEKLKPDIIQVENRPRFVRYLRRRHPRAKIVLSLHSVTFVSRPHIRLAELRRCLAAADRIVVNSEFIREEMERRDPRSRGKLVVNHLGVDPAGFASRWHGEGALRREAMTARLGLQGRRVLLYVGRLIPIKGVHHVLEAMPRIVQEVPNAVLLIVGSAFYGSKRTTPYVRRLHRMAKRMKEHVRFIPYVPHGEVADWFRLADVLVVPSGRREAFGLVNVEAMAAGVPVVATHAGGIPEIIEEGVTGLTVRLSSIGEELPERLAWLLRDEEAACRMGMMSVERVLEHFTWERTAERWLALYAELLPGKPGLELPPPPYPG
>NC_016935.1|WP_014372008.1|7276527_7277100_-|DNA-3-methyladenine-glycosylase-I
MTCRCAWVNEDPLYQEYHDKEWGVPVHEDRKLFEMLVLEGAQAGLSWYTVLKKRERYREVFDGFDPVKVAAYDEAKLGELLADPGIIRNRLKIRGAVSSAQAFLRVQEEFGSFDRYIWRFTDGQSVRNSWGSLSEVPAQTPQSDAMSKDLKKRGFTFVGSTICYAFMQATGMVMDHTVDCFRFKELGGEA
>NC_016935.1|WP_014372009.1|7277314_7278214_+|EcsC-family-protein
MNEELSVYEQQVQRKLEHWRAGLLKPPGMIERTSKAVQSRINQAIPEKVHAAITSAVKGIVQTALFSMDYIPKSEPSAGVSLALRDKEAEDKLAFYKKLAAAEGAGAGAGGFLLGMADFPILIGIKMKFLFELAHVYGYSTYDYRERLFILHIFQLAFSGQTARPPLYEAIAAWPQTMRTLPMASSYAEHIDWRKFQQEYRDTIDFRKMLQLVPGIGMVVGAWANYGLLEELGETGMNCYRLRWLAEARDRGPLPRSGGWLGSKEDGEPRFTTPPLPQDASPSRHNPMKEGDSYEDRQK
>NC_016935.1|WP_014372010.1|7278194_7278533_+|cupin-domain-containing-protein
MKIGKSNAEHYVWGGTCDGWHLVKQPELSVIHERMPPGTEEVRHYHGQARQFFFVLSGCAELEVDGTVHLLHPQEGCEVAPLVPHQMKNTSGQPVEFLVISHPQTRGDRFEA
>NC_016935.1|WP_014372013.1|7281563_7283207_-|S-layer-protein
MNRIKDHRLWKLLLTFTLALTLLVLPAPPADAASFSYSAYPKGTVGMKKPTIGFDVAETDASPRFSAFHMKVDGQAVDGTLDTAEMSYIYTPSEELAPGTHTVLVTLQFDGYQPIENSWTFEVAENAVDEVQADYSKNQQDGLKAINDYRTLYGLQPLKLNPNLTLAAKLHASYLSANQAAKSGLSLHKQQSGLPGFVGEGPGDRAVYAGYYKGIGEDVSFYTGTLVESIDALFDAPYHRSPFLNPDAKDLGIEMVGDYVVIEFGFADESADLNLVVSPAPGDPYVPLNFDGYEDPDPIRMHTAAKYPVGYPIMAVAEGANITSVELADAKLTDSSGNPVELLKNSPANDDHLKTAAILIPKAPLQPDTEYKAYVKLNVSRGGVPAVLEKSWSFRTEPADGIGKTKLHADASAYLKLAELTSPLKHVVSFKLDSDQYTLDGLRFPMKRAPFLLDGSSYLWVRDLSAALGASVTWDDSRKAAIYTKNGRTITFFTNRGAYEINGKSYTTGSPARLENELTLIPVRLLSEVLGAEVKYNEATRIVTITY
>NC_016935.1|WP_013920221.1|7283541_7284015_+|MarR-family-transcriptional-regulator
MKEDLDESLHLFVVLSRASEWVMAHAHRDIRRHGLNPTEYGVLELLYHKGPQPLQQIGSKILMTSGNITYVVDKLEDKGLVRRRPSEEDRRVSFAEITEEGREFLDEAFPSHREAIAHAVSALSPEEKQQAISLLRKLGLAAKENFKCAPIPGAKQP
>NC_016935.1|WP_014372014.1|7284143_7284920_+|pirin-family-protein
MQILIYPPSMQGTGSFDGGSITEQKPIGFSGEGSVVKRVGPLFYWAWARAEEEGYIPLHPHQGFEIMTYVLQGRAEHGDTLGTRSTVGAGGAQIMQTGSGVSHEERFIGPDMEAFQIWFEPAIRQALLRQPTYAQVEHGEFPAEQAEGCTRKTVIGEGSPVRLVTDALMWDVELEPGRLLRHPLPAGRTLTALAVRGGGSWHAADAPEKAGSFREKDFVLLHSHKDAEAVVTADAGGRLRLLLIEVPSSVDYPLYPKR
>NC_016935.1|WP_014372015.1|7285196_7286846_-|b(o/a)3-type-cytochrome-c-oxidase-subunit-1
MDNLPKPFDRRDSALILAHILFAFFALFLGGVAGLLQGLVRGGANALPFGIGYYQLLTAHGVLMALVFTTYFIIGFLYSGVARTLGTLLGLPRRLGWLGFGLMTTGTLWATVLILLNKATVLYTFYAPLKASPWFYVALVFVVVGSWMSGFGIFMQYRYWKVLHPGQTTPLFTFMAVVTMAMWLIATLGVAIEVLFQLIPWSFGWVETVNVVLSRTLFWYFGHPLVYFWLLPAYMCWYVVIPKVIGGRLFSDALARLSFLMFLLFSIPVGFHHQLMEPGISNVWKFVQVVLTFMVVIPSLMTAFSLFATFEMHGRSLGAKGLFGWLRKLPWKDVRFFAPFMGMLLFIPAGAGGLINASHELNAIVHNTLWVTGHFHLTVATSVALTFFGITYWLIPALTGRTLTPRMHRLGIAQTVIWLVGMLFMSGSMHTVGLLGSPRRTSFTTYQDHPDAVLWMPYHVAMAVGGTILFVGVLLMLFNIVTLLRAPKGRPEEFPIAEVSDAAEKAPALFERWGVWVGILVVLILVAYTIPVMDMLNHPGVGAKGFKTW
>NC_016935.1|WP_013920224.1|7286873_7287344_-|cytochrome-c-oxidase-subunit-II
MHIHRLEKLWLVFGISMLAVFLTVVGVGAFALGMEPPGGHRHTVDPEKLSTTAPFDKPGLQRLGNGEYEANIIAFAFGYKPDVIEIPLGAKVNFNITSSDVVHGFQVVNTTINMMVVPGEVNHLAYTFTEPGEYLVICNEYCGAAHEVMMMKLIVK

Crispr_ID: NC_016935_18

• CRISPR_ID: NC_016935_18
• CRISPR_location: 7302130-7302204
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_016935_18

Consensus_repeat	Method
TAGAGGAACTCAGGTGCGCTATTT	CRISPRCasFinder

spacers of NC_016935_18

>18.1|7302154|27|NC_016935|CRISPRCasFinder
TGTTCGTGGAGAGGTACGCTTCCGAGA

CRISPR arrays and Neighbor proteins around NC_016935_18

CRISPR arrays

The CRISPR arrays of NC_016935_18

>merge|NC_016935|18|7302130-7302204|CRISPRCasFinder
TAGAGGAACTCAGGTGCGCTATTTTGTTCGTGGAGAGGTACGCTTCCGAGATAGCGGAACTCAGGTGCGCTATTT

>NC_016935|18|13|7302130-7302204|CRISPRCasFinder
TAGAGGAACTCAGGTGCGCTATTT	TGTTCGTGGAGAGGTACGCTTCCGAGA
TAGCGGAACTCAGGTGCGCTATTT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016935.1|WP_013920231.1|7292742_7294311_-|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|213192
NC_016935.1|WP_013920250.1|7311917_7313141_-|response-regulator	unknown	unknown	gnl|CDD|381091
NC_016935.1|WP_041619303.1|7307833_7309363_-|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|224053
NC_016935.1|WP_014372021.1|7296797_7298060_+|MFS-transporter	unknown	unknown	gnl|CDD|341031
NC_016935.1|WP_014372024.1|7304985_7305930_+|glutaminase-A	unknown	unknown	gnl|CDD|274797
NC_016935.1|WP_013920234.1|7295379_7295634_+|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_013920229.1|7291208_7291871_-|thiaminase-II	unknown	unknown	gnl|CDD|381699
NC_016935.1|WP_013920239.1|7301469_7301946_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
NC_016935.1|WP_013920235.1|7295859_7296651_+|phosphatidylserine-decarboxylase	unknown	unknown	gnl|CDD|179544
NC_016935.1|WP_014372020.1|7294310_7294904_-|ECF-transporter-S-component	unknown	unknown	gnl|CDD|227065
NC_016935.1|WP_041617506.1|7313147_7314965_-|sensor-histidine-kinase	unknown	unknown	gnl|CDD|225519
NC_016935.1|WP_013920230.1|7291957_7292752_-|energy-coupling-factor-transporter-transmembrane-protein-EcfT	unknown	unknown	gnl|CDD|223692
NC_016935.1|WP_051045006.1|7315023_7316034_-|sugar-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|380624
NC_016935.1|WP_013920241.1|7302970_7303585_+|pyridoxamine-5'-phosphate-oxidase-family-protein	unknown	unknown	gnl|CDD|377290
NC_016935.1|WP_014372019.1|7290626_7290935_-|DUF485-domain-containing-protein	unknown	unknown	gnl|CDD|377315
NC_016935.1|WP_013920245.1|7306666_7307830_-|sugar-ABC-transporter-permease	unknown	unknown	gnl|CDD|226669
NC_016935.1|WP_013920247.1|7309463_7310588_-|sugar-binding-protein	unknown	unknown	gnl|CDD|380649
NC_016935.1|WP_013920242.1|7303777_7304656_-|AraC-family-transcriptional-regulator	unknown	unknown	gnl|CDD|225117
NC_016935.1|WP_013920237.1|7298213_7299614_-|HD-GYP-domain-containing-protein	unknown	unknown	gnl|CDD|225116
NC_016935.1|WP_014372026.1|7310928_7311798_+|DUF1963-domain-containing-protein	unknown	unknown	gnl|CDD|370378

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016935.1|WP_013920231.1|7292742_7294311_-|ATP-binding-cassette-domain-containing-protein	gnl|CDD|213192	cd03225, ABC_cobalt_CbiO_domain1, First domain of the ATP-binding cassette component of cobalt transport system. Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC transport system of the CbiMNQO family is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most of cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems.	5.29805e-75
NC_016935.1|WP_013920250.1|7311917_7313141_-|response-regulator	gnl|CDD|381091	cd17536, REC_YesN-like, phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators. This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	1.81094e-56
NC_016935.1|WP_041619303.1|7307833_7309363_-|ATP-binding-cassette-domain-containing-protein	gnl|CDD|224053	COG1129, MglA, ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism].	0
NC_016935.1|WP_014372021.1|7296797_7298060_+|MFS-transporter	gnl|CDD|341031	cd17478, MFS_FsR, Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters. Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.28995e-105
NC_016935.1|WP_014372024.1|7304985_7305930_+|glutaminase-A	gnl|CDD|274797	TIGR03814, Glutaminase_1, glutaminase A. This family describes the enzyme glutaminase, from a larger family that includes serine-dependent beta-lactamases and penicillin-binding proteins. Many bacteria have two isozymes. This model is based on selected known glutaminases and their homologs within prokaryotes, with the exclusion of highly-derived (long branch) and architecturally varied homologs, so as to achieve conservative assignments. A sharp drop in scores occurs below 250, and cutoffs are set accordingly. The enzyme converts glutamine to glutamate, with the release of ammonia. Members tend to be described as glutaminase A (glsA), where B (glsB) is unknown and may not be homologous (as in Rhizobium etli). Some species have two isozymes that may both be designated A (GlsA1 and GlsA2). [Energy metabolism, Amino acids and amines].	7.51952e-166
NC_016935.1|WP_013920237.1|7298213_7299614_-|HD-GYP-domain-containing-protein	gnl|CDD|225116	COG2206, COG2206, c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms].	2.11358e-71
NC_016935.1|WP_013920229.1|7291208_7291871_-|thiaminase-II	gnl|CDD|381699	cd19364, TenA_C_BsTenA-like, TenA_C proteins similar to Bacillus subtilis TenA. This family of TenA proteins belongs to the TenA_C class as it has a conserved active site Cys residue; the double Glu residues identified in the active site of TenA_E from the archaeon Pyrococcus furiosus is conserved in this family. TenA_C proteins (EC 3.5.99.2) catalyze the hydrolysis of the thiamin breakdown product 4-amino-5-amino-methyl-2-methylpyrimidine (amino-HMP) to 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP) in a thiamin salvage pathway. This family includes Bacillus subtilis TenA which has been shown to be a thiaminase II, catalyzing the hydrolysis of thiamine into HMP and 5-(2-hydroxyethyl)-4-methylthiazole (THZ), within thiamine metabolism. It has also been suggested that TenA proteins act as transcriptional regulators based on changes in gene-expression patterns when TenA is overexpressed in Bacillus subtilis, however this effect may be indirect.	7.52694e-111
NC_016935.1|WP_013920239.1|7301469_7301946_+|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	5.59517e-17
NC_016935.1|WP_013920235.1|7295859_7296651_+|phosphatidylserine-decarboxylase	gnl|CDD|179544	PRK03140, PRK03140, phosphatidylserine decarboxylase; Provisional.	4.87501e-101
NC_016935.1|WP_013920242.1|7303777_7304656_-|AraC-family-transcriptional-regulator	gnl|CDD|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	9.63969e-27
NC_016935.1|WP_041617506.1|7313147_7314965_-|sensor-histidine-kinase	gnl|CDD|225519	COG2972, COG2972, Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms].	8.19979e-79
NC_016935.1|WP_013920230.1|7291957_7292752_-|energy-coupling-factor-transporter-transmembrane-protein-EcfT	gnl|CDD|223692	COG0619, CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism].	2.36797e-23
NC_016935.1|WP_051045006.1|7315023_7316034_-|sugar-ABC-transporter-substrate-binding-protein	gnl|CDD|380624	cd19969, PBP1_ABC_sugar_binding-like, monosaccharide ABC transporter substrate binding protein. Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems that share homology with a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein superfamily, which consists of two domains connected by a three-stranded hinge. The substrate specificity of this group is not known, but it is predicted to be involved in the transport of sugar-containing molecules and chemotaxis.	6.02735e-118
NC_016935.1|WP_013920241.1|7302970_7303585_+|pyridoxamine-5'-phosphate-oxidase-family-protein	gnl|CDD|377290	pfam04299, FMN_bind_2, Putative FMN-binding domain. In Bacillus subtilis, family member PAI 2/ORF-2 was found to be essential for growth. The SUPERFAMILY database finds that this domain is related to FMN-binding domains, suggesting this protein is also FMN-binding.	9.38014e-25
NC_016935.1|WP_014372019.1|7290626_7290935_-|DUF485-domain-containing-protein	gnl|CDD|377315	pfam04341, DUF485, Protein of unknown function, DUF485. This family includes several putative integral membrane proteins.	2.78795e-25
NC_016935.1|WP_013920245.1|7306666_7307830_-|sugar-ABC-transporter-permease	gnl|CDD|226669	COG4214, XylH, ABC-type xylose transport system, permease component [Carbohydrate transport and metabolism].	2.88817e-155
NC_016935.1|WP_013920247.1|7309463_7310588_-|sugar-binding-protein	gnl|CDD|380649	cd19994, PBP1_ChvE, periplasmic sugar binding protein ChvE that interacts with a bacterial two-component signaling system. Periplasmic aldose-monosaccharides binding protein ChvE that belongs to a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein (PBP1) superfamily, which consists of two alpha/beta globular domains connected by a three-stranded hinge. This Venus flytrap-like domain undergoes a transition from an open to a closed conformational state upon ligand binding. Moreover, the periplasmic xylose-binding protein is homologous to the ligand-binding domain of eukaryotic receptors such as glutamate receptor (GluR) and DNA-binding transcriptional repressors such as LacI and GalR.	2.815e-167
NC_016935.1|WP_014372020.1|7294310_7294904_-|ECF-transporter-S-component	gnl|CDD|227065	COG4721, COG4721, ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism].	1.00811e-39
NC_016935.1|WP_014372026.1|7310928_7311798_+|DUF1963-domain-containing-protein	gnl|CDD|370378	pfam09234, DUF1963, Domain of unknown function (DUF1963). This domain is found in a set of hypothetical bacterial proteins. Its exact function has not, as yet, been described.	1.68701e-50

Protein sequences

>NC_016935.1|WP_013920239.1|7301469_7301946_+|GNAT-family-N-acetyltransferase
MTLPSSSIRIITAGRAELSAVVPLFDAYRRFYGQPSDPEGAERFLEGLMAHGDSVILLARQEGSAEALGFTQLYPGYSSVSMKRLWTLNDLYVRPEARGRGVAALLLEAAEGLARESGAKGLQLETAPDNRTAQRLYERMGYVRDEEYLHYFRSTMEN
>NC_016935.1|WP_013920237.1|7298213_7299614_-|HD-GYP-domain-containing-protein
MGNIASIALSPYRRFTWTLGLSVGFIGVLLSAVTLWACSTFVTRDTVELTTAAVVKHFAKVPQLAAIFPESSGEEGSTSPVGEPHTPHSQTPADLLQSYDRVLPLVRMHFDLYSILDANFYDTEGRIVFSYDKEAIGQEVDASLAGSLERAATNAQVVHQRLSGHILHLWMPVQREDGQVAGVVEVKRDISEQDRQIGWLEGILMTIIVLGMLGLFLTLHHVFRNSAGTIDRQNRELEAMVFRIERTYDESLQALSSALDSRDNETHGHSFRVTSYALRLGMEMNLTDRELGDLARGALLHDVGKIGVPDAILLKPAELTEEEWVVMKSHVEIGYRMLKHIAFLSPSLDVVRYHHERWDGGGYPHGLREEEIPLFARIFALCDSYDAMTSDRPYRKGWGYNEARAEIERCTGTQFCPEVVRAFLRIPKERWLEIEEASREGEPRELLGQMLEETMSMKAASMKGGR
>NC_016935.1|WP_014372021.1|7296797_7298060_+|MFS-transporter
MQLQTGAAAGPAAKPAPQPDVRPTLFRILFAISLVHLFNDTIQSVIPAILPIIKDSMQLSYMQAGIIVFALNMTASVMQPVVGLYSDRKPMPYMLPLGMGLTFFGVLGLALAPNYALVLVSVLLIGLGSAVFHPEGSRVAYMAGGSRRGLAQSIFQVGGNTGQSLASIMTALVFVPLGQFGAIWFTAVAGLAIVVQMYISRWYAGYLKAHPRPAKSAAARRIDPLRSRLIKFAVGMLIFLVFARSWYHAGITIYYPFYLMDKFTITLERAQLFIFLFTAAGVLSTFLGGPISDKIGRRNVIFFSMLGSAPLALVLPYANEFWTYVILLVNGFIILSSFSVTVVYAQELIPGKVGTVSGLITGLAFGLGALGAVALGGLIDVIKLRPVMELVSYLPLIGLLTFFLPRDRTLKEWSSESGNA
>NC_016935.1|WP_013920235.1|7295859_7296651_+|phosphatidylserine-decarboxylase
MKISFFRLLTELSSRKSVSQLTGAFAKSRASRSLIPRFAKTYGIPLEDAEKAVHEYVSLNDFFTRRLKSGLRPIDASPETMVSPVDALITGMGPIKEGSILNVKGQDYTIEELLNHSPRMINYKNGFYYVLYLSPTDYHRIHSPVDGTIIEKEHVPGKVYPVNDFGLKHMRRVLSRNERLITYVEHEGGEVAVVKVGALNVASIQYVAPLPDLLERGGELAYFEFGSTVVLLTETGTFESRSDLQVGSKVRMGEKLGSFKRRG
>NC_016935.1|WP_013920234.1|7295379_7295634_+|hypothetical-protein
MNETVTVPIESTPILLGLTAEMVSNCTYCTMISSDPGYRTPVSCTKLSGSCCPILVNLATCLTCGEYKNACGNGGASAEGTDAF
>NC_016935.1|WP_014372020.1|7294310_7294904_-|ECF-transporter-S-component
MSKGLKLTDILVTVVIAVVFAVIYRLWGDVYNVLKIPGLQLEQLGYGMWFIAGTVAFLILRKPGVAFLAEAAAASGEMIMGSQYGVEAFTYGLVQGLLAELVFAAAGYKRHTALIAGLAGAASGVGSIVYDYFKLYLAELQSWNLMLYIVFRLVGAFVITGPLAYVIVKALEKTGVTQLVRPASSLDYQALDRKKTL
>NC_016935.1|WP_013920231.1|7292742_7294311_-|ATP-binding-cassette-domain-containing-protein
MNAADTHTAHGSGGPSAQEQEPAVSVTGLRLKFPGSAPLLFDDLTLEVPRGQKVLLLGPSGCGKSTLLQVFSGLIPKSIEVPMKADALQLPDAWGYLFQDPDTQFCMPFVDEELAFVLENLQVPREEMGERIRLCLEQVGLRLPDLHTPIASLSGGMKQRLAIASLLALNPDVWFLDEPTSLLDPEGTGEVWETVKRVTEGRTVLIVEHKIEEIAGFVDRVVLFGHDARILADGPPQRVFREHRQELQEYGIWYPGVWEDYDRRPDLMPERGQSAARSAQVAQPLLRLEAFCGFHGREKKIEIPSADIFGDDWIAVVGPNGAGKSTLLQALMQLIPTQGRYNLGPRAVKGFDDVIGDASYVFQNPELQFVTHSVFDEVAWDFRQEGLPEAEVRTRSGEVLEWYGLAGHRELHPYQLSLGQKRRLSVASATGKARRLLLLDEPTFGQDAANTFALLEKLEEWRRGGSAIVMVTHDPEIVARFATRVWEVRGGRLAADLPPEAYRKLQAAGEAAAGKEAEAPCR
>NC_016935.1|WP_013920230.1|7291957_7292752_-|energy-coupling-factor-transporter-transmembrane-protein-EcfT
MPLTWTFRETWLHRANPAFKIGLSVLLFLAVLLTHNINVLLHVTWMHLLLFYTATGLPLRRLLLLSLPFVLMLVSSSTSMLFFGKGETTWLHWGLIHITEESFYRSLHIGLKTVNMAVLGLLFGLTTSPVRLFYSLMQQTRLPARYAYSFMAALRLLPMIVTEYQALQMALKVRGVKRARGIRGWTDSIQRHAIPLLAQSIRRAQRIAVAMEAKRFSSDAGRTYYYVIGWSASDLVLAAAALLIWTAGLLLGGHLPFLSVTDVR
>NC_016935.1|WP_013920229.1|7291208_7291871_-|thiaminase-II
MKFSQELREAADASWQASFNHPFVRGIGDGSLPLDAFRHYVLNDAYYLSQFARVQALGAAKANDLFTVNRMAVHAQGTYGAELSLHEKFAGLLGITEEERAAFEPAPTSYAYTSHMLRAAYAGGLGDIIAAILPCYWLYYEIGERLAGCTPEEPIYREWIAAYGGDWFRELVEEQIARLDELAETASSQDRERMKRHFVTSSRYEYMFWDMAYRKETWPV
>NC_016935.1|WP_014372019.1|7290626_7290935_-|DUF485-domain-containing-protein
MKAQVQAKRYADIARTPKFQDLMARKKKFLLPMSLFFLAYYFTLPILTSYSKVLNQPAFGPVTWAWIFAFSQFIMTWALCILYSRKSADYDRMIEEIREEHA
>NC_016935.1|WP_013920241.1|7302970_7303585_+|pyridoxamine-5'-phosphate-oxidase-family-protein
MRRKEFSVEEQNEIDAFLNEMSYGYLATEGADGWPHLTPLNYAYWNGNIYFHGSRAGSKMKEIAQSDKVSFAVSKEYAIIPSYYSDPRQACPATAFFKSVHIRGIAEPVEDLDEKAGALSSMMEKLQPEGGYAPITAEDPEYRGELRGVSVVRITVSELTAKFKFGQNMSEERRAHIAESLAERGRPDDAETAELMRRFCPHHQ
>NC_016935.1|WP_013920242.1|7303777_7304656_-|AraC-family-transcriptional-regulator
MDQASLYHPRYLEEECHLRTVAYYSKQWNGFQMPFHTHRAAEIMYVISGECTVEFAEDRVHLGKGDFILIDALVAHRLFVEESTVCRMLNVEFVLGPRQGAFPSFRQLAEENEVLRAMLGRVRPYLVLSDTTDVYHTLKSLVLELSDRSRGGFMVQLLLSQLLLRVARLAAEAEEHQANPGDLYVKKVIAYLHHHYDCDLRVKELAEAVNLHPSYLHRIFRLHTGSSIVEYLTALRIEKAKMLLAQTDIPVIEIPGYIGMNSRQYFSAVFKKQTGLTPLQYRLGIEAWQRDE
>NC_016935.1|WP_014372024.1|7304985_7305930_+|glutaminase-A
MNPKNDLNLIADKLPEWLEESRKYTVLGRPASYIPELAYAPAEALGVTVMGADGTEITAGDCGLTFTMQSISKVFTLLLALMDHGEDGVFQKVGMEPTGDDFNSMLKLELVPPGIPFNPLINAGAIAISSLIHGVSPSDKLSRILAFFREVSGDPDLTYNEAVYASESAHAHRNRSLAYFLKDNHVLDGDVEEVLDLYFKHCSIEVTCRHLARMALVLALNGKDPVSGRELIPKRYVAIAKTFMITCGMYNASGEFAIKVGMPAKSGVAGGILALVPGRFGVGVIGPALNHKGNSTAGVHLLQTMSEAMDWSIF
>NC_016935.1|WP_013920245.1|7306666_7307830_-|sugar-ABC-transporter-permease
MNTVKELFRGNIRQYGMVIALLFIMVFFQILTDGILLKPLNITNLILQNSYILVLAIGMLLVIITGHIDLSVGSVAAFVGAISAILMVDMQMHFVPAMLISLLIGALVGAWQGFWVAYVRIPSFIVTLAGMLLFRGLTMIVLDGKSIAPFPKTFQKISSGFLPDAFGGKIHMLTIIIGIVLSLILVFSEWRKRSTQQKYGFEVGSGALFALKLAAMVAVLNIFTYVLATYEGIPNILILLFVLIVIYTFVMNRTIVGRHIYALGGNEKAAKLSGVKTQRITFWVFVNMGVLSALSGLIFAARLNSATPKAGVNFELDAIAACFIGGASASGGIGTVIGAIVGGLVMGVMNNGMSLVGLGIDWQQGIKGLVLLLAVGFDIYNKNKGVS
>NC_016935.1|WP_041619303.1|7307833_7309363_-|ATP-binding-cassette-domain-containing-protein
MTDIILEMKNITKEFPGVKALERVNLQVKEGEIHALMGENGAGKSTLMKVLSGVYPHGTYTGDILFKGQVCEFKDIKMSENLGIVIIHQELALIPYLSIAENIFLGNERAKGGIVDWNETFVRTKELLDKVGLHESPNTQIAQLGVGKQQLVEIAKALAKRVQLLILDEPTAALNEDDSENLLQLLLELKRQGISSILISHKLNEISKVADSITILRDGRTIETLDMRRDNITEDRIIKGMVGRDLTQRYPEREPKIGETIFEIKNWNVFHPQQADRQVLHNINLGIRRGEIVGIAGLMGAGRTELAMSIFGRSYGQKISGTMIKDGRPLELRSIPEAIDSGIAYVTEDRKHYGLVLMDNIKQNITLANLGKISKRGVVDENREVVEAESYRKKMNIKSPSILQKTGNLSGGNQQKVVLSKWMFAEPDLLILDEPTRGIDVGAKYEIYTIIHQLAAEGKGVLIISSELPEVLGMCDRIYVMSEGRITGEFPRAEASQEKLMKFMTKTRG
>NC_016935.1|WP_013920247.1|7309463_7310588_-|sugar-binding-protein
MKKAVSMMMLLVLLFSLAACGGGGGAAETTGGAAQTEGGSGGDGKAGKVGISMPTKSSERWVSDGANMVKEFEKLGYQTDLQYAEDVVENQVSQIENMITKGVKVLVVAAVDGESLTDALDKANAAGIKVIAYDRLIKKSEHVAYYATFDNFKVGVQQASYIEKKLGLKEGKGPFNIELFAGSPDDNNAYFFFDGAMSILKPYIDSGKLVVRSKQTEMKQVATLRWDGAAAQARMDNLLSANYATEKVDAVLSPYDGISIGILSSLKGVGYGSGSKPLPVITGQDAELASVKSIIAGEQTQTVFKDTRELAKKAVAMADAVLKGKEAEVNDTKTYNNGVKVVPSFLLEPVSVDVTNYEQVLVGSGYYTKDQLAK
>NC_016935.1|WP_014372026.1|7310928_7311798_+|DUF1963-domain-containing-protein
MNKETILQALDAAGLGPYRDAISRLIYPSHRLLLHGTVENSMPPGASKIGGCPDLPPDLEWPTWRGYPQSFIAQLNLADLPPISPLPAAGVLYFFYAAQAMYGVRGFYEDPRTCSVFYLGADRIPSLQRRPHPETLDAGSTLYASRIEARPTLCVPSADSAYLESLGLGWDSNSEDYDTYWEIFLPQLEDRPSGIIHRLLGHPDQIQADMQMECEMLRRGWTWEDIGRPDQRQNLLPSAADWRLLLQIDSDERMTGMTWGDAGKIYFWIREEDLASLHFDGVTCIMQCT
>NC_016935.1|WP_013920250.1|7311917_7313141_-|response-regulator
MEKRWKVLIADDEPWIREGIRDAVDWTSLGMEVVAEAEDGEEALELALEHSAEVLLVDLNMPIMNGIELMKRVREELPGSRIVVITGHDEFVFAQEAIRLEVDDYILKPADPKQLHTVLGNVRRKLELAEKQNGYLAMASKQISKNFPLLRERFCLEWVEGTMTEGEILEQLQFLELPASAPQRLGIIRWPESSAPQRLMKESDRQLLLFAIENIAAELLEPYRHAMFRDTMGLLVVCLWEAVPESVYAEIERAVQTYLKLTVHLCFEHVEGSVTGIASVYRHCRTKVYEEQQISPIVRRARQYIRDRFTDSGLTLESAAAELQMSPVYLSRVLKQELGMPFVSLVTQMRIQLAVQLLGGTDLPVGEIAERAGYESQHYFSTAFKKVMGVSPNQYRRGVVSAGEQME
>NC_016935.1|WP_041617506.1|7313147_7314965_-|sensor-histidine-kinase
MNDLPIRDKLIIHFLLIIILPSVLLGGSILWTVDRIIEKQVSENTLQLIGKVNKTLESYAGNMQNITYFLSFQPEVKRFLERGPGTAQRGAAAEEYEIRQFMQGFTTLYPEVAGVLVVNAQGDYISNEMYARSSRSLTEEEWYKQAVASKGIFTMVGHPQGRNVTTHVSYKDSEVVSAVRAILDPQTQAVKGVVLIDLKLRVIAETAKDVRLGKSGYLTIIDGQGDVIYAPPRPLVSRIPAEWLGDHGSGTFAQEVGGEKLQFIYRASPFTNWTTVGVFSMEESALEAQEIGFYVVCFVFIVCLFGIAASYYLSHSISRPIVQLMSFMRIAESGDLTVRYWGDRRDEVGNLGRSFNTMIAQIDKLLTLTERQERQKREAELRSLQAHIKPHFLYNTLDTIHWMARKKGAEDVAEVVQSLSRLFRIGLSKGSDRIMLAHEIEHICSYLTIQKSRYKDKLNYTIDVPEHLMNVSVLKIVLQPIVENAIYHGIKERRGPGHISVEAEERWGMLLLRVRDDGAGMDAEKLRELQERLAAAAASEDEQGEPREPASYGMMNVQARIQLAFGTSYGLTIESEAGQGTTVTIIHPLLRDGLPPVKRTSEGGT
>NC_016935.1|WP_051045006.1|7315023_7316034_-|sugar-ABC-transporter-substrate-binding-protein
MKKLLWIYAILIGTFILYVVQYHTREVSSRAGGAHDGLRGEIGEKYVMVTFQSGMEYWKSSLKGFEDAAQALNVSVEYRGATQYDVHEQITVLEQVIAKKPEGIALSAIDPVRLTAAINKAVDAGIPVVLFDSGAPESRALSFLSTDNYNAGVTAARKMAELLGGQGETAVVTLPGQLNHEERKQGFIDTLHKEYPQIRLQSVKDGRGDRIYSKLAAADILKEFPEVDGIFATEANGGVGVGEAVQEAEAAGKVKIIGFDTDKDTLDMVKKGAISATLAQGTWNMGYWSLQFLFHQHHGLAGPGGGTKAAASSLPRNVDTGITVVTGDNVEQFYAK

Crispr_ID: NC_016935_19

• CRISPR_ID: NC_016935_19
• CRISPR_location: 7452097-7452222
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_016935_19

Consensus_repeat	Method
CGTTCCGTTGTGCTTCGCACAAAGGTCACTTTC	CRISPRCasFinder

spacers of NC_016935_19

>19.1|7452130|60|NC_016935|CRISPRCasFinder
AAAATCATATATCCTCGCTTGTATCAAATGCTTATCCGGGCGCTCGGGTATATGGTTTCT

CRISPR arrays and Neighbor proteins around NC_016935_19

CRISPR arrays

The CRISPR arrays of NC_016935_19

>merge|NC_016935|19|7452097-7452222|CRISPRCasFinder
CGTTCCGTTGTGCTTCGCACAAAGGTCACTTTCAAAATCATATATCCTCGCTTGTATCAAATGCTTATCCGGGCGCTCGGGTATATGGTTTCTCGTTCCGTTGTGCTTCGCACAAAGGTCACTTTC

>NC_016935|19|14|7452097-7452222|CRISPRCasFinder
CGTTCCGTTGTGCTTCGCACAAAGGTCACTTTC	AAAATCATATATCCTCGCTTGTATCAAATGCTTATCCGGGCGCTCGGGTATATGGTTTCT
CGTTCCGTTGTGCTTCGCACAAAGGTCACTTTC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016935.1|WP_014372107.1|7447907_7448687_-|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|379312
NC_016935.1|WP_013920346.1|7452487_7454383_-|PrkA-family-serine-protein-kinase	unknown	unknown	gnl|CDD|225357
NC_016935.1|WP_013920351.1|7459786_7461226_-|sn-glycerol-1-phosphate-dehydrogenase	unknown	unknown	gnl|CDD|341454
NC_016935.1|WP_014372110.1|7451050_7452058_+|UDP-glucose-4-epimerase-GalE	unknown	unknown	gnl|CDD|177883
NC_016935.1|WP_014372114.1|7461338_7462082_+|hypothetical-protein	unknown	unknown	gnl|CDD|227769
NC_016935.1|WP_041619316.1|7450656_7450839_-|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_013920336.1|7443078_7443786_-|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|223816
NC_016935.1|WP_014372108.1|7448955_7450515_+|PAS-domain-S-box-protein	unknown	unknown	gnl|CDD|236901
NC_016935.1|WP_014372105.1|7446132_7447503_-|MATE-family-efflux-transporter	unknown	unknown	gnl|CDD|240542
NC_016935.1|WP_014372112.1|7457262_7457997_-|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|225818
NC_016935.1|WP_014372106.1|7447729_7447918_+|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_014372117.1|7464414_7465740_-|MFS-transporter	unknown	unknown	gnl|CDD|340863
NC_016935.1|WP_014372113.1|7458036_7459782_-|histidine-kinase	unknown	unknown	gnl|CDD|225814
NC_016935.1|WP_013920335.1|7441569_7442892_-|globin-coupled-sensor-protein	unknown	unknown	gnl|CDD|381256
NC_016935.1|WP_049819081.1|7455059_7457180_-|carbon-starvation-protein-A	unknown	unknown	gnl|CDD|184976
NC_016935.1|WP_014372111.1|7454863_7455067_-|YbdD/YjiX-family-protein	unknown	unknown	gnl|CDD|377308
NC_016935.1|WP_013920334.1|7440613_7441147_+|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_013920337.1|7443818_7445951_-|histidine-kinase	unknown	unknown	gnl|CDD|380161
NC_016935.1|WP_014372116.1|7463248_7464178_-|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|223566
NC_016935.1|WP_014372115.1|7462319_7463084_+|polysaccharide-deacetylase-family-protein	unknown	unknown	gnl|CDD|213023

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016935.1|WP_014372107.1|7447907_7448687_-|class-I-SAM-dependent-methyltransferase	gnl|CDD|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	3.75461e-20
NC_016935.1|WP_013920346.1|7452487_7454383_-|PrkA-family-serine-protein-kinase	gnl|CDD|225357	COG2766, PrkA, Putative Ser protein kinase [Signal transduction mechanisms].	0
NC_016935.1|WP_013920351.1|7459786_7461226_-|sn-glycerol-1-phosphate-dehydrogenase	gnl|CDD|341454	cd08175, G1PDH, Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner. Glycerol-1-phosphate dehydrogenase (G1PDH) plays a role in the synthesis of phosphoglycerolipids in Gram-positive bacterial species. It catalyzes the reversibly reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in a NADH-dependent manner. Its activity requires a Ni++ ion. In Bacillus subtilis, it has been described as AraM gene in L-arabinose (ara) operon. AraM protein forms homodimer.	1.68435e-140
NC_016935.1|WP_014372110.1|7451050_7452058_+|UDP-glucose-4-epimerase-GalE	gnl|CDD|177883	PLN02240, PLN02240, UDP-glucose 4-epimerase.	0
NC_016935.1|WP_014372114.1|7461338_7462082_+|hypothetical-protein	gnl|CDD|227769	COG5482, COG5482, Uncharacterized conserved protein [Function unknown].	2.84819e-55
NC_016935.1|WP_013920336.1|7443078_7443786_-|response-regulator-transcription-factor	gnl|CDD|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.61883e-87
NC_016935.1|WP_014372108.1|7448955_7450515_+|PAS-domain-S-box-protein	gnl|CDD|236901	PRK11360, PRK11360, two-component system sensor histidine kinase AtoS.	3.22161e-72
NC_016935.1|WP_014372105.1|7446132_7447503_-|MATE-family-efflux-transporter	gnl|CDD|240542	cd13137, MATE_NorM_like, Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.	1.51088e-83
NC_016935.1|WP_014372112.1|7457262_7457997_-|response-regulator-transcription-factor	gnl|CDD|225818	COG3279, LytT, Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms].	7.98507e-62
NC_016935.1|WP_014372117.1|7464414_7465740_-|MFS-transporter	gnl|CDD|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.53615e-16
NC_016935.1|WP_014372113.1|7458036_7459782_-|histidine-kinase	gnl|CDD|225814	COG3275, LytS, Putative regulator of cell autolysis [Signal transduction mechanisms].	9.4361e-135
NC_016935.1|WP_013920335.1|7441569_7442892_-|globin-coupled-sensor-protein	gnl|CDD|381256	cd01068, globin_sensor, Globin sensor domain of globin-coupled-sensors (GCSs), protoglobins (Pgbs), and sensor single-domain globins (SSDgbs); S family. This family includes sensor domains which binds porphyrins, and other non-heme cofactors. GCSs have an N-terminal sensor domain coupled to a functional domain. For heme-bound oxygen sensing/binding globin domains, O2 binds to/dissociates from the heme iron complex inducing a structural change in the sensor domain, which is then transduced to the functional domain, switching on (or off) the function of the latter. Functional domains include DGC/GGDEF, EAL, histidine kinase, MCP, PAS, and GAF domains. Characterized members include Bacillus subtilis heme-based aerotaxis transducer (HemAT-Bs) which has a sensor domain coupled to an MCP domain. HemAT-Bs mediates an aerophilic response, and may control the movement direction of bacteria and archaea. Its MCP domain interacts with the CheA histidine kinase, a component of the CheA/CheY signal transduction system that regulates the rotational direction of flagellar motors. Another GCS having the sensor domain coupled to an MCP domain is Caulobacter crescentus McpB. McpB is encoded by a gene which lies adjacent to the major chemotaxis operon. Like McpA (encoded on this operon), McpB has three potential methylation sites, a C-terminal CheBR docking motif, and a motif needed for proteolysis via a ClpX-dependent pathway during the swarmer-to-stalked cell transition. Also included is Geobacter sulfurreducens GCS, a GCS of unknown function, in which the sensor domain is coupled to a transmembrane signal-transduction domain. Pgbs are single-domain globins of unknown function. Methanosarcina acetivorans Pgbs is dimeric and has an N-terminal extension, which together with other Pgb-specific loops, buries the heme within the protein; small ligand molecules gain access to the heme via two orthogonal apolar tunnels. Pgbs and other single-domain globins can function as sensors, when coupled to an appropriate regulator domain.	1.62721e-47
NC_016935.1|WP_049819081.1|7455059_7457180_-|carbon-starvation-protein-A	gnl|CDD|184976	PRK15015, PRK15015, carbon starvation protein CstA.	0
NC_016935.1|WP_014372111.1|7454863_7455067_-|YbdD/YjiX-family-protein	gnl|CDD|377308	pfam04328, Sel_put, Selenoprotein, putative. This entry includes a group of putative selenoproteins from Proteobacteria, Actinobacteria and Firmicutes. The invariant cysteine at the C-terminus is encoded by a TGA Sec codon in some Epsilonproteobacteria, suggesting a redox activity for the protein.	6.87675e-24
NC_016935.1|WP_013920337.1|7443818_7445951_-|histidine-kinase	gnl|CDD|380161	NF033092, HK_WalK, cell wall metabolism sensor histidine kinase WalK. This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.	3.32754e-48
NC_016935.1|WP_014372116.1|7463248_7464178_-|NAD(P)/FAD-dependent-oxidoreductase	gnl|CDD|223566	COG0492, TrxB, Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones].	1.36927e-61
NC_016935.1|WP_014372115.1|7462319_7463084_+|polysaccharide-deacetylase-family-protein	gnl|CDD|213023	cd10918, CE4_NodB_like_5s_6s, Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands. This family belongs to the large and functionally diverse carbohydrate esterase 4 (CE4) superfamily, whose members show strong sequence similarity with some variability due to their distinct carbohydrate substrates. It includes bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, hemin storage system HmsF protein in gram-negative species, intercellular adhesion proteins IcaB, and many uncharacterized prokaryotic polysaccharide deacetylases. It also includes a putative polysaccharide deacetylase YxkH encoded by the Bacillus subtilis yxkH gene, which is one of six polysaccharide deacetylase gene homologs present in the Bacillus subtilis genome. Sequence comparison shows all family members contain a conserved domain similar to the catalytic NodB homology domain of rhizobial NodB-like proteins, which consists of a deformed (beta/alpha)8 barrel fold with 6 or 7 strands. However, in this family, most proteins have 5 strands and some have 6 strands. Moreover, long insertions are found in many family members, whose function remains unknown.	5.77834e-68

Protein sequences

>NC_016935.1|WP_014372110.1|7451050_7452058_+|UDP-glucose-4-epimerase-GalE
MSILVTGGAGYIGSHTCVELLNAGQSIVVVDNLSNSKMESLERVRELTGRDFRFYEIDLLDKDKLGSVFAENEIEAVIHFAGLKAVGESVAQPLRYYENNITGTLNLCEQMQKHDVKKLVFSSSATVYGMSEQVPITEASPLSATNPYGRSKLIIEEILRDLHVSDPSWSIALLRYFNPIGAHASGRIGEDPNGIPNNLLPYISQVAVGKLQELRVFGSDYPTVDGTGVRDYIHVCDLAAGHLKAVDKVRSTTGVEAYNLGTGKGYSVLEVIRAFEEASGQKVPYAIVDRRPGDVAVCYADPAKAREELQWTAQRGIEEMCADAWRWQTGNPKGY
>NC_016935.1|WP_041619316.1|7450656_7450839_-|hypothetical-protein
MRRPPYGVFHGWGPKYGYPHYGYPKFGPWGGVPLVLPLPIPAPVPYYPYPPYPYGPYPYY
>NC_016935.1|WP_014372108.1|7448955_7450515_+|PAS-domain-S-box-protein
MQKIPVIRDKKSSDITIISSDDVVKIECIRDKEFIIHTVSDKYYWAASLEVFEEWLYEEGFRLIDQMNVVNMNHVTGYEPRKGVVTLRTGSSPRYKTASAAWIHGEHIMNVRSLLAKMKELDQGIPPSHEGDELFETVLAQEEDHRFARSYAMIKALYEKKKAELLLEESELRYKSLFEHNPDPICSLNLNGMLTSINPAMFQVIGYSEQELSGGTIEPLILPEHYPRWFQHFQETLNGSTPHYELTFIHKEGYPVEASVLNFPIFVGKQIAGVYMIGQDISDRKRAEEMLIRSEKLSVVGQLAAGVAHEIRNPLTSLKGFVQLLQGKINGYDNYFDIMLEELDRINFIVSEFLVIAKPQSVRFQKKDAGAILQNTLMLMGSQALIHNVDIHTHIDPDLPPILCDENQIKQVFINILNNSVDSMPAEGGQIHIDFGRADHDQVLMRFTDQGCGIPEDRLPRLGEPFYTTKEKGTGLGLMVTFRIIENHGGTLKFHSSLGQGTTVEIFIPAVVPGGTLAV
>NC_016935.1|WP_014372107.1|7447907_7448687_-|class-I-SAM-dependent-methyltransferase
MNKKAANIWNAGHYDEKIRYVSRLGQSLIGMLQPAAGERILDIGCGTGDLAWEIAKSGAHVTGIDSSEAMIAQAAAKYPALQFRCDDAQTFRLQAGEAPYDALFSNAALHWIRRPAEAAEAMALALRPGGRLVVEFGGCGNIAAIYRGIRTALAAAGIDAEERNPWYFPGIGEYASLLEAQGLNVRTAELYDRPTPLGDGERGLRNWLDAFAGMFFSGLSEPQKEAAYARCEEAVREELYRGGEYIADYRRLRITAVKR
>NC_016935.1|WP_014372106.1|7447729_7447918_+|hypothetical-protein
MSNPLQELTREMNEIERRYAGLGARMERLERRLSEMEERMDHLEDQAALLPERTANKAPVTV
>NC_016935.1|WP_014372105.1|7446132_7447503_-|MATE-family-efflux-transporter
MIRQLAAWTQNWKLILTLALPSIISFASGTVTGTINLMMVGGMGALVIAVVGVSNIIAYNAWALCSGFGHSVNYLVAQNYGAGQMDQAVRRTYIALYVGLAAAVLAVLTGWLAPGLILRAMGGSPELVAAGGSYLMYRLYAVACFTLSFILHGFFRGIGDTRTPMVMTIAANVAMIFFTYTLTYGRWGFPELGLSGAGLAVLIGEALGLLGSAYVYFVRLNGRYGTRRRVTVDRGEASLILAESGKLGMQELAMSLAMFVFTMFVTRLGTEALAANEIALNVMGLGFMPAFGFGATATILVGQEIGRGNPLGARRMAGDVAVLGSLFLLVLGTAELVFSTEVARLYTQDQAVYELAGRLIMASAYLQLFDGLLNYYAGGLRGLGDTTFLLRVSLILNWLLFVPLAYGLTFTAGLGSMGAWFSLYAFLAAFAVVLCIRFYRTDWYSVTVKQSPGHGG
>NC_016935.1|WP_013920337.1|7443818_7445951_-|histidine-kinase
MFSRTLWPYGAVLIISMCLFALVLAGGLAVLRQDGPPAAARQGVLTLDNPEQLRRGVLLEGEWEMFWGELLTPDDLAAAAPPRQGRPVVLPGTWTGLPSPEGKLPGLGYATYRLRVLLPPGTDDSSLLAVRIPPVNSAYRLWVGGTPVASAGEVGTTREASVPQYTKATAMFHSRNAELDIVLQIANFSHAKGGLRQSIELGGVEAVHRSADLAAGFDALLIGSLLIMGLYHLGLFSARPQSWSMFYFGMFCLLFSLRITLLGEVLLVKVLPGLDGELQLTLEYLTAVLSLPLFTRFFSNSFPQESSERYTRLFTLLPGAYALLVIVLPPVLFTRTLILLQLLISFCAVYIITIAARAARRRRTGARFLLVSCLLFFATVISDMLYAHELAVSRDTLSAFGLLFFVFSQSVMLSVKLSRTYVQEEQLTAALTALNSGLHSKVLERTAELEAANGELVRKNEELSRLESSRRRLISNISHDLGTPLTTIRCYLEAIMDGMVDTDEERERYVRLIHGKVLGMDRLIEDLFQLSQLEAGRVVFKFRPVPVDRLAGLLFGRYELDTRNSGIAYDLTVKRTGDAAGRAEFAVVEADMERLHQVFGNLIFNAMSFMSRGGRIEVTVTEDGSEMRCSVRDNGRGIEPKDLPYVFERHYSGRASPGKTSGGLGLSISKEIVEAHGGRIWIEWSEPGQGTLIMFTIPVHESAAPVEAVK
>NC_016935.1|WP_013920336.1|7443078_7443786_-|response-regulator-transcription-factor
MLGQTILLVEDDREIGEMIRKYLEKNEFRVVWSPNGGEAVALAARERPDLAILDVMLPDASGFEVCRELRGMTSAPILFLSCRKEEEDKINGLNLGGDDYITKPFSPNELVARVKANLRRPRLVAEGEPNGMKVQVGPIAIDRLSRTVTVEGRTVVLSRKEFDLLSFLALSPEKTFTHEELFREIWGQECFNDSRTIIVHISNLRKKIEPDPANPRYVINVHGVGYKFVRGISET
>NC_016935.1|WP_013920335.1|7441569_7442892_-|globin-coupled-sensor-protein
MSKCPFSTVAGWFGWKRDAKPAHHELFLKQEQMNQVAVSYTIDDSELDEQLRMIRFTEQDLRVIKMIQPLMVSQIDWIVEQFYDAVLKVGKLEKIIHDHSSVERLRRTLKVHLTELFSGQIDRKFVEKRIGIALIHQRIGLEPKWYMGAFQNLQNAFLQVVQTHVQDREESVVISGIVTKLLNFEQQLVLEAYEKENLRQRELEHERYRSDLRSISEELSLLTDVSSRSVDGLISSSGGVKEALEMTVQQSKTSQSLAGTGQERLNSLETRIHAIHDRADHMQTAIGQLSELMGQIKEIVTIVQDIAEQTNLLSLNAAIEAARAGEHGRGFSIVADQVRKLSEDTKTTLTRIGDIVSQSDKYNTNVIRSIAEVQQVVETSRKEAAEARRVFTGIMDSMQSNIDRTVDMESEMDTLQQVVREIGGAVSKVAASADTLRSRA
>NC_016935.1|WP_013920334.1|7440613_7441147_+|hypothetical-protein
MQEYITMAEALSVRAAITRRLHHLMQERMQNSTTVIEKGEQAEYPSRTVDLITEEIEKTSADYRTLDVLIAKANITHTIRWNDRDLTVLEAIELAKQTRSEIQMLNMLGAVKKMDRQVSRGGSSDGGKPLFTVALYDPEAYSRAAQKKEREAVRLSSLIEQSNHTHKLPFDASAYMG
>NC_016935.1|WP_013920346.1|7452487_7454383_-|PrkA-family-serine-protein-kinase
MSLFKKIADHRTETERLAWVGSFAEYVEKLRENPRLAMTAHARVYEMIASQGITEENGRRRYNFFDKEIFGLDSAVEKLVEEYFHSAARRLEVRKRILLLMGPVSGGKSTLVTMLKRGLEQFSRTDAGAVYAIQGCPMHEEPLHLIPHELRPEVEKELGVKIEGNLCPSCQIRLRDEYHGRIEDVLVERVLISEDNRVGIGTFSPSDPKSQDIADLTGSIDFSTITQFGSESDPRAYRFDGELNKANRGIMEFQEMLKCDEKFLWNLLSLTQEGNFKAGRFALISADELIIAHTNESEYKSFIANKKNEALQSRMIVMPIPYNLKVSEEEKIYSKLIQQSDMKHVHIAPHSFRAAAIFSILTRLKESKKQGMDLVKKMRMYDGEEVEGYKEADLKEMQNEYLEEGMSGIDPRYVINRISSALIRHDLEFINALDVLRALKDGLDQHPSITKEERERYLNFISIARKEYDELAKKEVQKAFVYSFDESAKTLFNNYLDNIEAYCNWAKIKDPLTGEEMDPDERLMRSIEEQIGISENAKKAFREEILIRMSSYSRKNRRFDYSSHERLREAIEKKLFADLKDIVKITTSTKTPDGNQLKRINEVIKRLVEEHGYTTASANELLRYVGSLLNR
>NC_016935.1|WP_014372111.1|7454863_7455067_-|YbdD/YjiX-family-protein
MFERVKTVLQYRQQFLDLLVGVPNYETYVKHMQECHPELPVQTREEFFREAQDARYNAKGGKVSRCC
>NC_016935.1|WP_049819081.1|7455059_7457180_-|carbon-starvation-protein-A
MQALSYPLEGNAVARSFKSILLWGIVSVLGAFAFATIALNRGESVNAMWLIIAAVSCYAVAYRFYSRFLAHKVFGLDDNRKTPAELKNDGKDYVPTNKWVLFGHHFAAIAGAGPLVGPVLAAQMGYLPGTLWIVIGVILGGAVQDFVILFASTRRNGKSLGEMIKEELGPVAGAIAMVGILGIMVILLAVLALVVVKALIGSPWGMFTIAATIPIALLMGMYMRYIRPGRVVEASLIGLVLLLGSLIAGKYVAESEYLSAMFTFSGEAIALMMIAYGFIASALPVWLLLAPRDYLSTFLKIGTIVGLALGIFVVMPELAMPATTKFIDGTGPVFAGNLFPFLFITIACGAVSGFHSLISSGTTPKMLERESHARPIGYGAMLMESFVAIMALIAACVITPGAYFAINSPAAAIGTDAVQAAAKLTSWGFTITPDDLTGLAKDVGETTILSRTGGAPTFAIGMAHILSGVIGGKALMAFWYHFAILFEALFILTTIDAGTRVGRFMIQEILGSFSKRLGNTESTLGNVVATALCVAGWGYFLYQGVVDPLGGINSLWALFGIANQMLAGMALILGSTILLKMGRKKYAWVTLVPTAWLLVVTMTAGWQKLFHPEAKIGFLKHAAQYKEAMASGKLIAPAKNMAQMQQIITNDYVDAALCGLFMIIVLLVFLSALRTWYRVLAKGQLEVNEAPYVARGQDGREATTYV
>NC_016935.1|WP_014372112.1|7457262_7457997_-|response-regulator-transcription-factor
MGYKVVIADDEAPAREELAYLTGQIPDVLSVVTASGGMEAVRRVQEEQPDLLFLDMDMPDLSGRQVAQLLAELQPGLKIVFSTAYDQYAVDAFKLRAFHYLLKPYDEEEVAEVFRELRKAAVPVTPKPAAAGGGCVKLALEVEGGIKYVFPAEVQYISKEGKHVLVHTGGGAYPVGYTLQELEQKLAPYGFFRCHKSYLVRLAAITELKSWINGAYDVRIDDEAGTTVPVSRNYVKELRLKLEI
>NC_016935.1|WP_014372113.1|7458036_7459782_-|histidine-kinase
MFHLLVDMLERVGFLIALAFVFSRSRWMRGYMSYGGDGTYPWRFVLFFSLYAMLGTYSGVTVTDYSYRPAPWIGEISPASAIANSRSVGVVIAGLLGGPWIGLLVGGLAGLHRYSLGGFVAVACMIAPLLQGLLGGLCRRPLRKRLRRASSSAIRLAFLAGLLAELLQMGLILLIARPWHDALTLVSLIGGPQTLANSIGVALFFVLYQTIESEEDRIGTEHARKALHIADLTMPLWRLPFDRAVEEVARTLNEETKAVGASFLKGSSELAHQGRKTAYFIDLPLETQNRTTLGAFRLFYERVRELSPSRRLMLRTLAGLMSQQYAFVEAERQAQLLADAEIRSLQAQMNPHFLFNVLNTVKSFIRTKPDEARTLVTQLSRFLRTNMKNSSRTLITIREELELVTSYLSLTQARLGDQLQLVTEIDERAVERLLPPFTIQPLVENAILHGTRNSGRPGLIRIRIREQGGEVEVSVEDNGSGMPLHGERSGGEEHAGMALDNIAQRLGYHYGTEEPLEIRSEPGGGRWSGFAYRHRRSRPSRRPEGLDEPAWMSRVFRSAWCVLLALSEGESPGSQVSIHEQ
>NC_016935.1|WP_013920351.1|7459786_7461226_-|sn-glycerol-1-phosphate-dehydrogenase
MMDMELGWKLERAEGLGLEQAGEIDPWLGRSFYCESCGKDHAVPIRRVIIERGALAALPDYAQERELRSLLLVCDRHTAKAAGEELLGRCREAQLDARLVVLTEDEHGELAADERAIVQLLLHVDAASQAIVAVGSGTLHDIVRFAAFKTGRVFLSVPTASSVDGFASVGAPLILGGFKQTVPACAPEAVFADLALLAHAPQTLTAAGFGDMLGKYTSLADWELGRLLLDEHVCELSAEMTRQALARCVDHVDEIAAGTEEGQRRLMEGLILSGISMLIVGHSRPASGAEHHLSHFWEMRFLQLRRRALLHGAKVGVAAVRMAGLYAQTAQLSAEAVRAAAAQRLADPAFLSPAQAEAAIAAGYGTIADQVRAENAAELDPAGREALLRGIGERLASRWEAVQAVCRSVPGPEQMAQWLSRAGGPVAEAQLGVEPELVEQSLRYAKYVRSRYTILRLQEWLAGTAAQPEVAAGVQAQTE
>NC_016935.1|WP_014372114.1|7461338_7462082_+|hypothetical-protein
MAIKSETELYAPVKAYLEELGYSVRGEVRHCDVVAVRGEEPPLIIELKRSFSIPLLLQGIDRLRLTRSVYVAFERPAKGKAPHSATWPELRKLCGMLGLGMITVQFYKTRKPRVEVECHPLEGQALYPLASPPRHSKYAAGKLLQEFQERRADYNVGGSSKRKLVTAYREKSLQLASLLGSHGPMSPKQLRDLTGQAQAASMLQKNYYLWFRRVERGVYTLSPQGEEALKTYAHVVDGLPSLDMAQR
>NC_016935.1|WP_014372115.1|7462319_7463084_+|polysaccharide-deacetylase-family-protein
MSLTARRCARLFLLVCCLLLSVSASAVSAPQPVRIPVLNYHSITVDPGNRATITPVKFEEQMTHLAENGYTTLTLRQFTDIMEGRETAPEKPVLLTFDDGYADNYTEALPVLSRLGLNATLFVSPGVSAADPYFLTWDQIREMHEAGWDIQPHGMSHPHLPRLSAAKQEAELTEAKRLIEEQLGTTADVFCYPYGEYNRTTLRLLKKAGYRYAFTIKQGVTLPTQDPYRLTRIFVNGEESFETWRNRLEKAYQP
>NC_016935.1|WP_014372116.1|7463248_7464178_-|NAD(P)/FAD-dependent-oxidoreductase
MYDCIIVGGGIAGLQAAIQLGRYRHKVLVIDKQKGRSALCGSYHNLLGWPEGVSGPELRERGRRHAERLGVEFLEDEVIAAAKSDDQFQVALAGDGGSFKSQTLLIATGVMDRFPPLPGLEERLGESIYICPDCDGYEVMDRKAVVMGAGEAGSGMAMAISYWTDRITYVNHDRSAVSTSKREALEARGIEYIEEEIEEVLGGEDKSFRGVRLKDGRVIEGERAFIAFGGNRVITDWAMPLGIERLENKHIVTDPRTKMTGVPGVWAAGDVGIHAEQTSIAMGEGALAAIWIHKELVKRLRQMTVEHSG
>NC_016935.1|WP_014372117.1|7464414_7465740_-|MFS-transporter
MGSLGQWAKEQWSLRREAVPEERRLSKEAGVSLFIHFCFQFGASMSGVFLTLYLWRLTHSLAINGIYYAVTYAVAPFAFALGGWLIKRKDRMVTYRIGIAMTAAFYLGVVFAGEKVAEYYLVFAVLNGISSAFYWAGYLTLMYDVSTDSNRIRFLAINMVLFTLGGLIGPALAGFMITQSEGLQGYTLVFGTACFMFLIATIVSMKIPLKPSHHKAYYLKFTGLLMHRSRAWLHSLLAFGLMGLFQGMMLFLPNILLFQLVGREDLVGYLGVLYAGLSIGTNLFLSRFGSEEKAVKFIVISTAGFLFATCFLIWKMTLFTVIAFMILYSVCAPLQGNTITSTYFRIIGRLPLKGQLRVESVVMREVFLNGGRVVSIFSLLGLMEYAGDQVLPWVLAAASLLQIGLAGLISSREEGEGRQAHRLLARTGKDNAPGGTAGTRL

Crispr_ID: NC_016935_20

• CRISPR_ID: NC_016935_20
• CRISPR_location: 7765677-7765765
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_016935_20

Consensus_repeat	Method
AAGGATCTTTCCCCGCTCTCCGG	CRISPRCasFinder

spacers of NC_016935_20

>20.1|7765700|43|NC_016935|CRISPRCasFinder
CCTGCCCTCGCTGACGAAGCTGCTGCTGGATGCCAACGGGATT

CRISPR arrays and Neighbor proteins around NC_016935_20

CRISPR arrays

The CRISPR arrays of NC_016935_20

>merge|NC_016935|20|7765677-7765765|CRISPRCasFinder
AAGGATCTTTCCCCGCTCTCCGGCCTGCCCTCGCTGACGAAGCTGCTGCTGGATGCCAACGGGATTGAGGATCTTTCCCCGCTCTCCGG

>NC_016935|20|15|7765677-7765765|CRISPRCasFinder
AAGGATCTTTCCCCGCTCTCCGG	CCTGCCCTCGCTGACGAAGCTGCTGCTGGATGCCAACGGGATT
GAGGATCTTTCCCCGCTCTCCGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016935.1|WP_014372273.1|7779535_7780450_+|NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|224995
NC_016935.1|WP_013920638.1|7760995_7762042_-|AAA-family-ATPase	unknown	unknown	gnl|CDD|273670
NC_016935.1|WP_013920635.1|7757237_7758890_-|response-regulator	unknown	unknown	gnl|CDD|381091
NC_016935.1|WP_041619326.1|7753966_7754416_-|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_013920645.1|7771244_7771751_-|TerB-family-tellurite-resistance-protein	unknown	unknown	gnl|CDD|143581
NC_016935.1|WP_013920633.1|7754428_7755418_-|substrate-binding-domain-containing-protein	unknown	unknown	gnl|CDD|380661
NC_016935.1|WP_014372278.1|7788875_7789388_+|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_014372270.1|7771938_7772250_+|Dabb-family-protein	unknown	unknown	gnl|CDD|214884
NC_016935.1|WP_013920637.1|7760073_7760961_-|ADP-ribosylglycohydrolase-family-protein	unknown	unknown	gnl|CDD|377122
NC_016935.1|WP_014372264.1|7759140_7760010_-|TIGR02452-family-protein	unknown	unknown	gnl|CDD|226745
NC_016935.1|WP_014372277.1|7786541_7787198_-|Bax-inhibitor-1/YccA-family-protein	unknown	unknown	gnl|CDD|198414
NC_016935.1|WP_013920632.1|7751073_7752150_-|galactose-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|380481
NC_016935.1|WP_013920660.1|7787406_7788627_+|YsnF/AvaK-domain-containing-protein	unknown	unknown	gnl|CDD|131324
NC_016935.1|WP_041617990.1|7749342_7750854_-|sugar-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224053
NC_016935.1|WP_041619330.1|7769310_7770747_-|RtcB-family-protein	unknown	unknown	gnl|CDD|376465
NC_016935.1|WP_014372263.1|7755414_7757241_-|sensor-histidine-kinase	unknown	unknown	gnl|CDD|225519
NC_016935.1|WP_014372272.1|7777458_7779420_-|hypothetical-protein	unknown	unknown	gnl|CDD|235388
NC_016935.1|WP_014372274.1|7780503_7780914_-|MerR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|133388
NC_016935.1|WP_013920643.1|7767854_7769204_-|ATP-binding-protein	unknown	unknown	gnl|CDD|223540
NC_016935.1|WP_014372267.1|7763720_7765106_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016935.1|WP_013920633.1|7754428_7755418_-|substrate-binding-domain-containing-protein	gnl|CDD|380661	cd20006, PBP1_ABC_sugar_binding-like, monosaccharide ABC transporter substrate-binding protein such as CUT2. Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems that share homology with a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein superfamily, which consists of two domains connected by a three-stranded hinge. The substrate specificity of this group is not known, but it is predicted to be involved in the transport of sugar-containing molecules and chemotaxis.	1.73053e-121
NC_016935.1|WP_013920638.1|7760995_7762042_-|AAA-family-ATPase	gnl|CDD|273670	TIGR01526, nadR_NMN_Atrans, nicotinamide-nucleotide adenylyltransferase, NadR type. The NadR protein of E. coli and closely related bacteria is both enzyme and regulatory protein. The first 60 or so amino acids, N-terminal to the region covered by this model, is a DNA-binding helix-turn-helix domain (pfam01381) responsible for repressing the nadAB genes of NAD de novo biosynthesis. The NadR homologs in Mycobacterium tuberculosis, Haemophilus influenzae, and others appear to lack the repressor domain. NadR has recently been shown to act as an enzyme of the salvage pathway of NAD biosynthesis, nicotinamide-nucleotide adenylyltransferase; members of this family are presumed to share this activity. E. coli NadR has also been found to regulate the import of its substrate, nicotinamide ribonucleotide, but it is not known if the other members of this model share that activity.	6.27251e-48
NC_016935.1|WP_013920635.1|7757237_7758890_-|response-regulator	gnl|CDD|381091	cd17536, REC_YesN-like, phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators. This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	1.30857e-54
NC_016935.1|WP_013920645.1|7771244_7771751_-|TerB-family-tellurite-resistance-protein	gnl|CDD|143581	cd07177, terB_like, tellurium resistance terB-like protein. This family consists of tellurium resistance terB proteins, N-terminal domain of heat shock DnaJ-like proteins, N-terminal domain of Mo-dependent nitrogenase-like proteins, C-terminal domain of ABC transporter ATP-binding proteins, C-terminal domain of serine/threonine protein kinase, and many hypothetical bacterial proteins. The function of this family is unknown.	6.01029e-08
NC_016935.1|WP_041619330.1|7769310_7770747_-|RtcB-family-protein	gnl|CDD|376465	pfam01139, RtcB, tRNA-splicing ligase RtcB. This family of RNA ligases (EC:6.5.1.3) join 2',3'-cyclic phosphate and 5'-OH ends. They catalyze the splicing of tRNA and may also participate in tRNA repair and recovery from stress-induced RNA damage.	3.74682e-128
NC_016935.1|WP_014372270.1|7771938_7772250_+|Dabb-family-protein	gnl|CDD|214884	smart00886, Dabb, Stress responsive A/B Barrel Domain. The function of this domain is unknown, but it is upregulated in response to salt stress in Populus balsamifera (balsam poplar). It is also found at the C-terminus of a fructose 1,6-bisphosphate aldolase from Hydrogenophilus thermoluteolus.It is found in the pA01 plasmid, which encodes genes for molybdopterin uptake and degradation of plant alkaloid nicotine. The structure of one has been solved and the domain forms an alpha-beta barrel dimer. Although there is a clear duplication within the domain it is not obviously detectable in the sequence.	1.21699e-21
NC_016935.1|WP_013920637.1|7760073_7760961_-|ADP-ribosylglycohydrolase-family-protein	gnl|CDD|377122	pfam03747, ADP_ribosyl_GH, ADP-ribosylglycohydrolase. This family includes enzymes that ADP-ribosylations, for example ADP-ribosylarginine hydrolase EC:3.2.2.19 cleaves ADP-ribose-L-arginine. The family also includes dinitrogenase reductase activating glycohydrolase. Most surprisingly the family also includes jellyfish crystallins, these proteins appear to have lost the presumed active site residues.	1.32118e-64
NC_016935.1|WP_014372264.1|7759140_7760010_-|TIGR02452-family-protein	gnl|CDD|226745	COG4295, COG4295, Uncharacterized protein conserved in bacteria [Function unknown].	1.71617e-85
NC_016935.1|WP_014372277.1|7786541_7787198_-|Bax-inhibitor-1/YccA-family-protein	gnl|CDD|198414	cd10432, BI-1-like_bacterial, Bacterial BAX inhibitor (BI)-1/YccA-like proteins. This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.	1.45309e-30
NC_016935.1|WP_013920632.1|7751073_7752150_-|galactose-ABC-transporter-substrate-binding-protein	gnl|CDD|380481	cd01539, PBP1_GGBP, periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species. Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species. GGBP is a member of the pentose/hexose sugar-binding protein family of the type 1 periplasmic binding protein superfamily which consists of two alpha/beta globular domains connected by a three-stranded hinge. This Venus flytrap-like domain undergoes transition from an open to a closed conformational state upon ligand binding. Moreover, the periplasmic GGBP is homologous to the ligand-binding domain of eukaryotic receptors such as glutamate receptor (GluR) and DNA-binding transcriptional repressors such as LacI and GalR.	1.56079e-150
NC_016935.1|WP_013920660.1|7787406_7788627_+|YsnF/AvaK-domain-containing-protein	gnl|CDD|131324	TIGR02271, Stress_response_protein_YsnF, conserved domain. This model describes an uncharacterized domain, sometimes found in association with a PRC-barrel domain (pfam05239, which is also found in rRNA processing protein RimM and in a photosynthetic reaction center complex protein). This domain is found in proteins from Bacillus subtilis, Deinococcus radiodurans, Nostoc sp. PCC 7120, Myxococcus xanthus, and several other species. The function is not known.	7.7062e-39
NC_016935.1|WP_041617990.1|7749342_7750854_-|sugar-ABC-transporter-ATP-binding-protein	gnl|CDD|224053	COG1129, MglA, ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism].	0
NC_016935.1|WP_014372263.1|7755414_7757241_-|sensor-histidine-kinase	gnl|CDD|225519	COG2972, COG2972, Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms].	4.64643e-65
NC_016935.1|WP_014372272.1|7777458_7779420_-|hypothetical-protein	gnl|CDD|235388	PRK05286, PRK05286, quinone-dependent dihydroorotate dehydrogenase.	3.34215e-31
NC_016935.1|WP_014372273.1|7779535_7780450_+|NAD(P)-dependent-oxidoreductase	gnl|CDD|224995	COG2084, MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism].	1.21468e-27
NC_016935.1|WP_013920643.1|7767854_7769204_-|ATP-binding-protein	gnl|CDD|223540	COG0464, SpoVK, ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones].	9.06407e-26
NC_016935.1|WP_014372274.1|7780503_7780914_-|MerR-family-transcriptional-regulator	gnl|CDD|133388	cd01282, HTH_MerR-like_sg3, Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily. Putative helix-turn-helix (HTH) MerR-like transcription regulators (subgroup 3). Based on sequence similarity, these proteins are predicted to function as transcription regulators that mediate responses to stress in eubacteria. They belong to the MerR superfamily of transcription regulators that promote transcription of various stress regulons by reconfiguring the operator sequence located between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	7.9103e-34

Protein sequences

>NC_016935.1|WP_014372267.1|7763720_7765106_+|hypothetical-protein
MPHRFTFRTRTLLALSVSLAFSGLSLPSGFPSAQPASAAPAAGSAETPAAIEAFLQDRYGLSLPAAPTKGDFIAETAEILELGDAAIAGPFTDVSVSDAVYRPALALYSQGILTSDTVGAAAPLTRGTAVYLAVKAAGLKELAYTYPQEKVQASLSRLGLAYPGDGRLTLQAAQELAAAADSGLLPEAYAASFDPWAPAGKAFAAVLLGQILSVRGEYKHYLTTTGDSEVYSKLLQAYRTQVLIEVPALQPAVDQALKEGLITGYNLKDERYAPHFDKSRSLTYGHSDIAHAVQLIGLLRSEGLQAKIQLEPKTSAFLYLKEWGEPETSPDYKVVPLENGNGIAYAREYDLSFEFDTAEQKETFNGIISAYAKKNSEDQHGLITGSWWQPLYYSLTELPEYKLIANNVIQGDGYYAQTFTLVDQAQAFADGIKKIKPDAGVDSYTFWVDEPFYNYLLGGFK
>NC_016935.1|WP_013920638.1|7760995_7762042_-|AAA-family-ATPase
MNAGAQGTLGLTLGKFAPLHKGHQYMIETGLKETDHLIVVIYDCPETTDIPLTVRAGWIRSLYPEAEVIEAWDGPAETGYTPRIQKLQEDYILGLLGGRRVTHFFSSEPYGDHMSRRLGAVNRQVDPARTVFPVSGTAVRQKPYANRAYVDGLVYRDLITRVVLLGAPSTGKTTLASALAEAHGTVWMPEYGREYWAAHQRDRRLTPEQLVELAEGHVVREEELAGEADGVFFTDTNAVTTYLFSLDYHGMALPRLEELARKAAFAYDLVFLCGDEIPYDDTWDRSGEVHRGKFQKRFTALLKEWRVPYIEVSGTLEERVAAVSAVLQAYRRYESLGNRWASGLQASR
>NC_016935.1|WP_013920637.1|7760073_7760961_-|ADP-ribosylglycohydrolase-family-protein
MNIMDRIRGGLYGTAVGDALGGTTEFMTRAEIRKKYGRLTEMIGEGVWDLEPGEVTDDTMMSLCVAEGILASPEDPMGAIGERFLDWYRSDPKDIGNIIRRALQRYEGDWLEASFVTNRDLGGFSAGNGSLMRCLPAALIYTDRERMETVTRMQSKMTHWDERCSEACVMYNRMAYRLLQGEELGLVLALETAGTPYAEALGGEPDCGPTGYVVDTFRWVLYILNTTQSFVETVQEAANLGGDTDTIGAIAGGLAGVHYGYGSIPEAYAGKILVKERLDELAERVAAYRREAGDR
>NC_016935.1|WP_014372264.1|7759140_7760010_-|TIGR02452-family-protein
MNRSNRAAVAAQTLEMLEAGGYGDAAGEWVDLRTAQEAAVRGSVLYRPGTDEELRGRALARLQEASVANAGSPAAMRIELTPETTLAAAHRCWLEDGEPAACLNFASAKNPGGGFLGGSQAQEESLARASGLYPCIVQMQEMYEYNRGRRTALYSDYMIYSPAVPVFRDDEDRLLPEAYPAAFITAPAVNAGVVREREPEAAEQIGSVMRGRIRRVLYAAMLHGHCTVVLGAYGCGVFRNRPQEVAAWFREVLAEEAFAGAFVRVVFAVYDRSAGQETFRAFEKEFGGG
>NC_016935.1|WP_013920635.1|7757237_7758890_-|response-regulator
MYKLLLVEDEADVREGILAEIDWAACGFEVVDAAENGQEAVELMERFVPDVVVTDIQMPFMDGLQLSEWIRERYPTTKIIILTGFDEFEYAQKAVKLHIDEYLLKPYSSEDLVGMLAKIKSQIDEEAARKENVQTLQEHYRKSLPVLREVFLASLVTRRLPLREIQEKCESYNLDLQDCGFAVSLLSLDNLGADEQSAGAADSGSLRRSKDTELKLFAVLNIAEEIVQKHGLGLVFVHNRHVVLLSAVKGAQRESLMERTLAALEEIRQSIDKYLKFTVTIGVGTFCPALPEVSYSYQDAVLALDYRPILGDNRIICISDVETRFVEKLRFDELKEHALIRCLKVGTTQEIGEIVESLFEGIADMGVSFKDYQIYLIEILTAILKAAKDSNADLDAIFGPDFVPLAELHKFTNPQEAKNWVLGICTNIMSRIASERQYAYKSLVDQAKEYIQQHYHETDISINKVCGMLHISAGYFSSIFKKEAKTTFGSYLSQIRMEAAKELLRTTDLKAFEIAEKVGYAEPNYFSFSFRKYAGVSPKEYRSAAAEEQR
>NC_016935.1|WP_014372263.1|7755414_7757241_-|sensor-histidine-kinase
MKRRVPQPPGRGPLSSLIDIWKVKSIQFIITASFMLMTLLVMVVVSVLLYDKFARTAEQNAFIGNEQIVEQVKLNVEMYLDGMDQAFKMVDERIRASKTVPDPKLEEQLRTILETRSDVVSMALFTAQGTPLAHLPETEMRRNTRITDQSWFRSAVENPGHVTVSLPHVQNLYKGRYPWVVSMSKSIILERDGVREPAMLLVDFNFKTIDDLLSRVSLGQRGYVYIIDESAGNMVYHPQQQLIYAGLKYENVEQAMKYAYGNYVDDSTGETRLITIQTVNNIGWKMIGVSYMNEIVTAKREIGWFLAWLMLGALVFVLLLSAFMSAKISQPIRRLERSMSKVEQGVFDIHIQEGGEDEVGRLSRRFNLMVARIRELMEQSVKEQEAKRKSELEVLQSQINPHFLYNTLNSVVRLAGSGKSEEVIRMITSLSKFFRISLSKGKSVITVQEELEHVRNYLIIQTMRYKNKFRFEIECEDEVKDCPTVKLILQPVVENAIYHGIEMMVDEGFIRIRAERAGDRVRITVADDGLGMPPEKVKGLLQAEAPENGGPGPGSSSGSGVGIRNVHERIRLMYGEEYGLEIESRLEEGTTVTLWIPYRTGVRGGEAG
>NC_016935.1|WP_013920633.1|7754428_7755418_-|substrate-binding-domain-containing-protein
MNGRLPGRIMLLLVLLAVSAGITSCGQLTDTAEAGYTGKKEIALIVKSKNSDYWKAVISGAEAAEKELGVDVLVEAPESEQDIQGQIGLISDVINYKRSALVLAPSDDMAPADAVARAAANNIPVITIDSRLDSPKPLSYIGVNHYEAGEKAGRKLAELLGDQGRAAVVGFKPDGQAAAERERGFLDEMARHPKIQVVEKTYCYADPDQCGEGVRRLAHVLNTPTGIAVLHGASTRGVVEEIVKEGLEGRVKVVTMDSTPEDIEYLQEGIVQATIIQNPFSMGYLGVQYAVDALEGRRVKENFFTDTKVIDQVNMFWSDNQKLLFPFVK
>NC_016935.1|WP_041619326.1|7753966_7754416_-|hypothetical-protein
MRSISVGIGNKVQEPAAAAAGFYSIRALSGFTPLLLYASPALRLSALRLSGFTPLGFTPLLLYASSALRLSALRLLALRLLALRLSALRLSALRLSGFTPLGFTPLGLKPLGMLGREIAELRFVMMAIEGEFLKIKELRFAIRWDVYVD
>NC_016935.1|WP_013920632.1|7751073_7752150_-|galactose-ABC-transporter-substrate-binding-protein
MNKKVVSMMLAAALATTVVGCGNKTDTNAGTANNNAGGAKTETGTTAGKQPTIGVAIYKFDDTFMTGVRNAISAAAEGKAKVDIVDSQNSQPTQNDKVDLFITKKVNGLLVNPVDRTAAGVIIDKAKAANIPVVFLNREPLADDMKKWDKVYYVGAKAEQSGTMAGQLVADYFKAHPEADKNKDGKLQYAMLKGEPGHQDAELRTKFAVKAVEDAGIGVEKLAEDTAMWDRVKGQEKMAAFLASQGDKIEAVFANNDDMALGAIEALKAKGYFQGGKYMPVVGVDATAPAVKALEEGTMLGTVLNDAKNQGAASFALANVLASGQTPSKENTGFEITDGKYIWVPYKKITKENMNDAK
>NC_016935.1|WP_041617990.1|7749342_7750854_-|sugar-ABC-transporter-ATP-binding-protein
MTDSKYLLEMNGIVKEFPGVKALDGVTIKVRPGTVHALMGENGAGKSTLMKSLFGIYKPDAGEIILDGEKVEINNSKDALNYGVSMIHQELHPVPHRNVMENIWLGRFPMKGFGPFKIVDHRRMLEDTKKLFEDLEMDIDPKELVGNLSVSKIQSLEIAKAVSFNSKIIVMDEPTSSLTGNEVEALFKIINELRSRGVSMIYISHKMEEILRISDDVTIMRDGKLIGTWPAAELTTDLIIQRMVGRDLSQRFPDRTNVPGGVLMKVEGLTSPLPKSFKDVSFELRKGEVLGLGGLVGAQRTELIEALFGLRAVESGEVSIHGKKVKIKSPIDAKKHKMALLTEERRVTGIFPVLSIHENAMIANIDRYETPFKLLNERKAKEEVARSVEKLRVKTPSVREKIKNLSGGNQQKVLLARWLLTEPDILLLDEPTRGIDVGAKFEIYSIINDLASQGKSIIMISSEMPELLGMSDRIMVMSEGRLTGIVEGKGATEEEIMRLAANH
>NC_016935.1|WP_013920643.1|7767854_7769204_-|ATP-binding-protein
MARGLTIDDLNERAAGRSSDGSIGAAAGLLFRQEEARGLQGMGDYPQYAQVTEKIEALLRERTGKSFTLYLQDDYGRQLWQVLEEDVKKGSRDVEHLASVYEGLETKAFTSEEESGDEEPGVFPTLRNNLFFYAQRGVALAQVPVFRRQGLDMEDFIWAEDDDCMKGFTAYVRDRRRDTDRRRVTVFTDTREGLEIEKMSITRGVGRDEVVMDAALKTEIFRSIDEFFAGDRQFFRDYGIPYKRGLLLYGRPGNGKTTLVKSIAGSVQAPVAYWQITEHTSSYSVQQVFSNAVSLAPMVLVIEDIDSMPENVRSFFLNTLDGATSKEGVFLIGTTNYPERIDPALMNRAGRFDRAYEIRLPDEAQRLHYLTLKRLGELCGEEALAAAARGAEGFSFAQLNELYVSAAFRMHYEKRVDIAQLVQEMRSDLGRAASQVWHSADAPPKVGFR
>NC_016935.1|WP_041619330.1|7769310_7770747_-|RtcB-family-protein
MNDIKDWEDEYYRRMRLPAGDLHVYANRELFEAMETQVFTMANNNLQIPGGHYLSYTPDVHVGVGTCIGTTAVWRAEEAYVSPSIVGSDIGCGMRVHVTNLQREELQDLKLRRKLVRAVEKLLPADSQSRGQFADFRLEEVVRKGLHGLPRKYVPDAYTPKKATSLSHVEHSRFRFDEEYLERMPEAAWHRGHRQLGTLGSGNHFAEIQALEIPEEARATAEQWGLKDGQIIVMIHSGSRAWGGAVNELAGREVAKWMRSSGMGTADPKLAFAPLDSEAGQLYLHLMYSALNYAVVNRHLIAYAIREAAKDVFGSRFEMRTLYDLMHNYAWEEEHEGEAYFVHRKGATRALPPGHPDNPEPYRATGHPALIPGSMGTASYLMAGLPQGRANYHSICHGAGRVRSRSATKRLVSAGDFASALGVGTPDEVVVNQRSLEAIVDEAPQAYKDVDAIIDSVVGAGLAGVVAKCVPLAVIKGV
>NC_016935.1|WP_013920645.1|7771244_7771751_-|TerB-family-tellurite-resistance-protein
MGLFDMFKGDKSTEGMTPHFAFATSLLYMMQSDGEMDNEEVGQLLAVLGGEKSGGTIGVGANNRALLDRALKYIRSNSIDTFLKEAAPILTDAQKMCILVNLVDSSLADGEPERQEQELFAKFLTAFNITEQRFTPFFEVIMLKNDRSVFLDQSHPKNQPGYQVSLNV
>NC_016935.1|WP_014372270.1|7771938_7772250_+|Dabb-family-protein
MSMYEHIVAFRFHKPIGPEIERGLLEQLHAFKGRIPGIVEVTAGVNMTEEKDNIHDYTLGLRVTFDSLEALRAYGPHPVHQEFVRSLDGILKNVVVIDYPIAT
>NC_016935.1|WP_014372272.1|7777458_7779420_-|hypothetical-protein
MPDWSYQSLFRPLLFRLPSLPARDLTLGAMGLLSRIPGGTFVIKTLGHMESHPILEGELCGIPVKYPVGLSGSLDIRGAAQKALAQFGFGFMEIGPVTVREIPGSLPVGRDTAEETLVYPEPAVNVGLERLLGRLARGEGHTLPRFFRLRPMPGASPAEASAQLKEMAAKLAPYAAGFHIDVLTPEVRDSWTLEAAAGVMRAVREAGAAEPEQGGRPMLFYLPLDFTAAGFAALLPFLRQQAWDGLVVGEAVYSAQGAAHIGRGGLEPALAQLRRVRSALGPGLPLVAAAGIHQPQDALDAVEAGADAVLLHSGLVFSGPGLPKRINEALIYEKVRGAAPPALPSFWAHWGWMCLLGLGMILGGVLAWMIAATTVVLPYDVSFLGMDPALLDLANSGILRFMSHDRVTLAGTMISIGVVYFQLAYHGLRHGQHWTRTALMTSGLVGFSSFFLYLGYGYFDPLHALAAALLLPMFVLAMRAPADRPSYEPAGRLNSPEWRLAQLGQLLFVVLGFALAAGGVIIASIGITRVFVPTDLEYLCATPEMLNEINARLIPLIAHDRAGFGGALFSDALAVLIIALWGIGEGRRWVWWTLALGGLPAFLAGFSVHYFIGYTSFIHLLPAYFAFMLYALGLVFLYPYMMGRAAARKDEAR
>NC_016935.1|WP_014372273.1|7779535_7780450_+|NAD(P)-dependent-oxidoreductase
MMNKEQAQIRMNPEDRPPVTVVGLGPMGRALAGAFLRGGHPVTVWNRTAGKAGELVAQGAFLADSLTAAISASPLVIVCVLDYHVVRTLLGPEAQALGGRTLVNLTADTPSRSREMAAWAAGYGIDYLDGAIMTPTPTIGSPAAVVLYSGPEAVYEASRPALAAIGGSASYLGTDPGRAAAYDVALLDVFWTAMSGYTHALALARAERIAPREFAAYAKGIAAILPDIMEYMAAFVEEGHHPGDASNLNSAAAGMDHIIQASEDHGMEAGVMKAARALVQRALDAGHGNDGFSWLTGLLEKDSV
>NC_016935.1|WP_014372274.1|7780503_7780914_-|MerR-family-transcriptional-regulator
MKIGELSRLTGASTRSIRHYEKKKILPAVRLGNDYREFDESAVERIRIIQLYLGLGLTVEQIENILRGENSGPEEYEFCEEMLELYRQKADRIQEQIRDLQTVKARLDRQIKAMLDKKRARERAALSEGAEQTAPV
>NC_016935.1|WP_014372277.1|7786541_7787198_-|Bax-inhibitor-1/YccA-family-protein
MQQQTLTYSDRGSLGHILRMFSLSLLVSFVGTLLGAVFVPPALVPAFIVAELVMLVAAFVLRMRGRHIGYGFLYSFTAISGVALYPVIMHYGGVLGANIVSGAFFATTVIFGSLAWYAYRSKSSFSFLGGFLFAGTIGLILMSVIAIFVPMGPAVNLVWSTLGILIFSGWVLYDVAQYRDGVEPEEVPLAALNMYLNFINLFLYILRFLAAIAGWNRD
>NC_016935.1|WP_013920660.1|7787406_7788627_+|YsnF/AvaK-domain-containing-protein
MSKQIVGVFNTEEEAIRVIDQLKDQGYSADDISVVGKNRGGLDMIEDETGSKAEEGVATGAAAGGMLGGVTGLLAGIGALAIPGVGPVIAAGPIAAALTGAAVGAGAGGIVGGLIGLGIPEDEARDYDAYVQEGKILVLVESDAVRDEHAFGTFRSNNSLNADRYGTDYSYRADKDSALDRAGDAIDRSADRAADAIERGWEKTKDAVGSAADKTADAVDRLDGEVERPYAGNADAANVSVYGQSLDGTATADLSRSNLGAPLNETEAERELRLREERLQVDKERVQSGEVSIRKEVIEEQQTINVPVSREEVYIERRDVTDGRTDNTPLGEDEVIRIPVTEERVEVTKKPVVTGEVAVGKREVTENRQVSDTVKREEAVIDSTGETRVKGDLVDADEELINRNRR
>NC_016935.1|WP_014372278.1|7788875_7789388_+|hypothetical-protein
MVAVLYSLLWILAAFRWADRNWERYYPTLLFSVIGNCLYELLCYRYPLWQMEPNGLPAAMIPILLLILIGMPLSTWVYLSLYPSGGGWLAQARHILAFTAVFILLEFVSVKCGSITYHNGWHLGWSLLFNIFMFIMLRIHFLKPLTGLVLSAAYTLLLMSLFHVSLDKMK

Crispr_ID: NC_016935_21

• CRISPR_ID: NC_016935_21
• CRISPR_location: 7921116-7921250
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers
• Cas_protein_info: WYL

Consensus repeat of NC_016935_21

Consensus_repeat	Method
CTTTCGGCTGCAGCGCCGCTTACGACT	CRISPRCasFinder

spacers of NC_016935_21

>21.1|7921143|27|NC_016935|CRISPRCasFinder
AGAACATCGCTTTCGGCTGCAGCGCCG
>21.2|7921197|27|NC_016935|CRISPRCasFinder
ACAGCACCGCCTGTTTCAAATACGCCA

CRISPR arrays and Neighbor proteins around NC_016935_21

CRISPR arrays

The CRISPR arrays of NC_016935_21

>merge|NC_016935|21|7921116-7921250|CRISPRCasFinder
CGTACGGCAACAGCACCGCTTACCTCAAGAACATCGCTTTCGGCTGCAGCGCCGCTTACGACTATATCGCCGCTTACACCTACAGCACCGCCTGTTTCAAATACGCCACTTTCGGCTGCAGCGCCGCTTACGACT

>NC_016935|21|16|7921116-7921250|CRISPRCasFinder
CGTACGGCAACAGCACCGCTTACCTCA	AGAACATCGCTTTCGGCTGCAGCGCCG
CTTACGACTATATCGCCGCTTACACCT	ACAGCACCGCCTGTTTCAAATACGCCA
CTTTCGGCTGCAGCGCCGCTTACGACT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016935.1|WP_014372377.1|7922549_7924166_-|chaperonin-GroEL	unknown	unknown	gnl|CDD|234573
NC_016935.1|WP_014372374.1|7916690_7918202_-|TROVE-domain-containing-protein	unknown	unknown	gnl|CDD|368584
NC_016935.1|WP_014372379.1|7924745_7925483_+|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_014372372.1|7915060_7915645_-|RNA-2'-phosphotransferase	unknown	unknown	gnl|CDD|179136
NC_016935.1|WP_014372371.1|7914260_7915064_-|TatD-family-hydrolase	unknown	unknown	gnl|CDD|182449
NC_016935.1|WP_014372378.1|7924158_7924473_-|co-chaperone-GroES	unknown	unknown	gnl|CDD|178988
NC_016935.1|WP_014372376.1|7920273_7921089_+|WYL-domain-containing-protein	unknown	unknown	gnl|CDD|379100
NC_016935.1|WP_014372383.1|7930400_7931462_-|hypothetical-protein	unknown	unknown	gnl|CDD|373896
NC_016935.1|WP_014372370.1|7912975_7914019_-|glycosyltransferase-family-2-protein	unknown	unknown	gnl|CDD|133005
NC_016935.1|WP_013920806.1|7921983_7922481_-|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_014372373.1|7915862_7916648_-|nucleotidyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|313370
NC_016935.1|WP_014372384.1|7931658_7933266_-|response-regulator	unknown	unknown	gnl|CDD|381091
NC_016935.1|WP_014372369.1|7911895_7912726_-|TatD-family-hydrolase	unknown	unknown	gnl|CDD|238635
NC_016935.1|WP_014372381.1|7928240_7929053_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|224097
NC_016935.1|WP_014372368.1|7911282_7911849_-|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_014372375.1|7918934_7920302_+|WYL-domain-containing-protein	WYL	pfam13280_WYL_CAS-I:CAS-III	gnl|CDD|379100
NC_016935.1|WP_014372382.1|7929042_7930149_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|226361
NC_016935.1|WP_013920812.1|7927431_7928244_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|224098
NC_016935.1|WP_014372367.1|7910911_7911232_-|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_014372380.1|7926358_7927435_-|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|270381

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_016935.1|WP_014372375.1|7918934_7920302_+|WYL-domain-containing-protein	WYL	pfam13280_WYL_CAS-I:CAS-III	6.6e-34	112.1	1.1

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016935.1|WP_014372374.1|7916690_7918202_-|TROVE-domain-containing-protein	gnl|CDD|368584	pfam05731, TROVE, TROVE domain. This presumed domain is found in TEP1 and Ro60 proteins, that are RNA-binding components of Telomerase, Ro and Vault RNPs. This domain has been named TROVE, (after Telomerase, Ro and Vault). This domain is probably RNA-binding.	7.50854e-21
NC_016935.1|WP_014372372.1|7915060_7915645_-|RNA-2'-phosphotransferase	gnl|CDD|179136	PRK00819, PRK00819, RNA 2'-phosphotransferase; Reviewed.	5.4304e-67
NC_016935.1|WP_014372371.1|7914260_7915064_-|TatD-family-hydrolase	gnl|CDD|182449	PRK10425, PRK10425, 3'-5' ssDNA/RNA exonuclease TatD.	4.16693e-115
NC_016935.1|WP_014372376.1|7920273_7921089_+|WYL-domain-containing-protein	gnl|CDD|379100	pfam13280, WYL, WYL domain. WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the WYL-like superfamily, named for three conserved amino acids found in a subset of the superfamily. However, these residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by a cysteine, which are predicted to line a ligand-binding groove typical of the Sm-like SH3 beta-barrels. A WYL domain protein (sll7009) is a negative regulator of the I-D CRISPR-Cas system in Synechocystis sp. It is predicted to be a ligand-sensing domain that could bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas and other defense systems such as the abortive infection AbiG system.	1.65303e-08
NC_016935.1|WP_014372383.1|7930400_7931462_-|hypothetical-protein	gnl|CDD|373896	pfam15493, YrpD, Domain of unknown function, YrpD. This family of proteins is found in bacteria. Proteins in this family are typically between 236 and 351 amino acids in length. The member from Bacillus subtilis, UniProtKB:O05411, is named YrpD.	8.12917e-82
NC_016935.1|WP_014372377.1|7922549_7924166_-|chaperonin-GroEL	gnl|CDD|234573	PRK00013, groEL, chaperonin GroEL; Reviewed.	0
NC_016935.1|WP_014372373.1|7915862_7916648_-|nucleotidyltransferase-domain-containing-protein	gnl|CDD|313370	pfam10127, Nuc-transf, Predicted nucleotidyltransferase. Members of this family of bacterial proteins catalyze the transfer of nucleotide residues from nucleoside diphosphates or triphosphates into dimer or polymer forms.	2.05236e-112
NC_016935.1|WP_014372384.1|7931658_7933266_-|response-regulator	gnl|CDD|381091	cd17536, REC_YesN-like, phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators. This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	6.51027e-47
NC_016935.1|WP_014372369.1|7911895_7912726_-|TatD-family-hydrolase	gnl|CDD|238635	cd01310, TatD_DNAse, TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.	1.85472e-67
NC_016935.1|WP_014372381.1|7928240_7929053_-|ABC-transporter-permease	gnl|CDD|224097	COG1176, PotB, ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism].	1.81871e-79
NC_016935.1|WP_014372370.1|7912975_7914019_-|glycosyltransferase-family-2-protein	gnl|CDD|133005	cd02511, Beta4Glucosyltransferase, UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide. UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.	1.1536e-47
NC_016935.1|WP_014372375.1|7918934_7920302_+|WYL-domain-containing-protein	gnl|CDD|379100	pfam13280, WYL, WYL domain. WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the WYL-like superfamily, named for three conserved amino acids found in a subset of the superfamily. However, these residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by a cysteine, which are predicted to line a ligand-binding groove typical of the Sm-like SH3 beta-barrels. A WYL domain protein (sll7009) is a negative regulator of the I-D CRISPR-Cas system in Synechocystis sp. It is predicted to be a ligand-sensing domain that could bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas and other defense systems such as the abortive infection AbiG system.	4.28525e-23
NC_016935.1|WP_014372382.1|7929042_7930149_-|ABC-transporter-ATP-binding-protein	gnl|CDD|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	4.3809e-158
NC_016935.1|WP_013920812.1|7927431_7928244_-|ABC-transporter-permease	gnl|CDD|224098	COG1177, PotC, ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism].	3.6958e-78
NC_016935.1|WP_014372378.1|7924158_7924473_-|co-chaperone-GroES	gnl|CDD|178988	PRK00364, groES, co-chaperonin GroES; Reviewed.	1.20327e-45
NC_016935.1|WP_014372380.1|7926358_7927435_-|ABC-transporter-substrate-binding-protein	gnl|CDD|270381	cd13663, PBP2_PotD_PotF_like_2, The periplasmic substrate-binding component of an uncharacterized active transport system closely related to spermidine and putrescine transporters; contains the type 2 periplasmic binding fold. This group represents the periplasmic substrate-binding domain that serves as a primary polyamine receptor of an uncharacterized ABC-type transport system from gram-negative bacteria. Polyamine transport plays an essential role in the regulation of intracellular polyamine levels which are known to be elevated in rapidly proliferating cells and tumors. Natural polyamines are putrescine, spermindine, and spermine. They are polycations that play multiple roles in cell growth, survival and proliferation, as well as plant stress and disease resistance. They can interact with negatively charged molecules, such as nucleic acids, to modulate their functions. Members of this family belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	8.96878e-146

Protein sequences

>NC_016935.1|WP_014372376.1|7920273_7921089_+|WYL-domain-containing-protein
MKRRIPNPFEKIFSYSIMSRLDESASFTSTSHERAWLKRMLEHPAASGAFTAETLGKLRGLLTAEDDLSFSGGFVEKAGAAGRPLYHPLLRPLRRMILAGSGMRLTIRTRSGLEFTRQPGFPYKLEYSMARREWYLLWYHRDEQTLLTTKLDTVLGVYAEPVSETETAAALGRIKDILDARREQALIEVLPAYRRELSRILYAFSCFDKEVIYEEAQEVYRIRLTYLSDEAEYVLSKLRFLGKRVRVVEGPRLQQRMLESARLALGRYGQG
>NC_016935.1|WP_014372375.1|7918934_7920302_+|WYL-domain-containing-protein
MARESFDKEIQFLRMLVLTSGAYDRQQYARRLGISVHTFDKTIRRLKEVLGTVYRQLPGEESREFADMLRYRYYESADPLLLFLYRAKSLKESESRRLALLLSSLQETPQTALELLDTCCSELPDDTPLPDEKTIRSDLKYLEEVGVIRREPGPRPYRYRLQDGLLTDLSFDELCDLYDYVDIMANTQVPSVQGYLLRDSLKRALRIKADGMETADRRPLQDRDSLLTEPFCYKYHYPSRILDEAHLHTLLHAIEHRRRIQFLYFSPKSGAHYGSRNTNPLFERETSGTLESAQPLRVVYDHQYGRWYLLAAHPKMGIRTYRVEGMTQIVEGEEVSEDVHLERQQALQMKLGRSWLLDTSRPVKVRARFYRPAGGQPDWIRERVELQGQWGCITEEDETSFVYEIEVSGTTEIKPWLRSFGSSCEVLEPRRLRQELIDEWKEIEGYYEAQDSESL
>NC_016935.1|WP_014372374.1|7916690_7918202_-|TROVE-domain-containing-protein
MSHARKLFGRTRPQTYNHEGYTVHTRSLEEQYLQTLLTNTMGGTFYADGGELLEDAHRMHQEMAQQDPQFMARALVFARSEGFMRLQPLYGLAVLSGIRPDLFARAFPGVVRIPSDLADFLTILRGLGRGQGGRAVKRQVNRFLSGVTEYWALKYNGRGRGYSLGDAIATAHPKPADEKQRTLFRYLRGKETDLSLLPQIAALEELKRAGSEAEQLHWIGAGRLPYETVTGAIQPTREIWEALLYQMPQFALLRHLNALDRAGVFGSPEHLRYAVSRLTDREALERSRILPFRFAAAFRQVGHPELRDALRAAVDHTFDALPDLPGRTAVFLDISGSMNGEYLQTGSVFALALYKKTQGASIFWLFDTEVVDPRPSRYDSILGQAEQIHTRGGTDTGAPVRRLTREKQHVDRIIIITDEQQNSGSPFYRDLQAYRAKVNPEAQAFIVDIAPYRHAMVPPEDPRTFYIYGWSDTVLSYIAQASQGYGSMVERVATMEWEEENTG
>NC_016935.1|WP_014372373.1|7915862_7916648_-|nucleotidyltransferase-domain-containing-protein
MTNIREEIITQLHRIEEEENVRILYACESGSRAWGFPSQDSDYDVRFLYLRPLDWYLSIDEGRDVIERPISDRLDLSGWDLRKALRLFRKSNPPLLEWLQSPMPYLEKYTTAEQIRRISPLTFSPKSCIYHYLNMAKGNFREYLQGDQVKIKKYFYVLRPLLACSWIEKYGTMAPMEFDVLVERLIPADSELYTAVQTLLARKKAGDELDYEPKVGPINAYLEEQIAYFEQAAVLQPSGGGSKDVGLDALFRGALREVWGE
>NC_016935.1|WP_014372372.1|7915060_7915645_-|RNA-2'-phosphotransferase
MPTPVSEQRLSKFMTKLLRHTPGEFGLSLDPADGSCTVEALLQAIRTQRSWAWVTEEDLAAVVRRSEKQRFELRDGRIRARYGHSHDRVTYEPGVPPDLLYHGTNSGAAAEILAEGLSPMNRQYVHLSEGTGFASLAGSRRGELVILRVDTKKAGELGVTFYFAGNEVWLADGVPASCLAVHPLPGKQKGARPQ
>NC_016935.1|WP_014372371.1|7914260_7915064_-|TatD-family-hydrolase
MTGNHTSELIDIGVNLTHRSFHADREEVIARALAAGVSVQVLTGTSLRSSTEAARLAARYPGQLYATAGIHPHDARGCDDTTIPRLRELAALPQVTAIGECGLDYNRDFSPRDVQRRWFEEQLGLAAETGLPLFLHEREAHADFAALLRQHRAYIGRAVVHCFTGTAYELHKYLDMGLYIGITGWICDERRGKHLRELVKRIPLERLMLETDAPFLTPRDLSPKPKDGRNEPAFLPHILQTVAACMGKSAEEVAEATTRTARTFFGI
>NC_016935.1|WP_014372370.1|7912975_7914019_-|glycosyltransferase-family-2-protein
MIVKNEAQDLARCLESAGPLVDEIVIADTGSTDNTREIALSYGAKVYDYAWTHNFSDARNFALRQSTGDWNLVLDADEYILNDCGGEIRDFIARHQGIGRIKRIDKFEQNGEVMESQVFISRLFPKGTFYTGIIHEQVVTDLPALKTSIEVYHDGYFRRSKSDRNLKLLRSAVKEHPLDAYFLFQLAKEYRMAGDYRAAAPYFAQCYEHLRREEAFYPLAVVDYLYNIIASRHLEEGLELIEREKTFLPDYPDFHFVCGHYYRELVFSNIEKYIAYFPQIEQSFLTCLALGETSRYDSVRGTGSFLPAYNLGVFYETTGDTAKARMYYETAARDGYKPAADRLAKLG
>NC_016935.1|WP_014372369.1|7911895_7912726_-|TatD-family-hydrolase
MPPFKPSHASMYPVMDTHIHLDAYGAEDREALLSSLADCGVQALVAVSMGLASCAEVLRLSRQAPPGRIRCAFGYHPEQPLPDAAEEEALFAWIRANQGAMAAVGEVGLPYYLRQAAEARGEAFPLDGYVRLLERFVRLAAELGKPIVLHTVYEDADIALDLLERHGVHRAHFHWFKGSGDTLRRMERLGCHVSLTPDVVYKEKTQAVAAAVPLDRLMAETDGPWPFEGPFAGRTTHPSMIRQAVRKIAEIKGLREEEAGRILYANSCRFYGIPAV
>NC_016935.1|WP_014372368.1|7911282_7911849_-|hypothetical-protein
MKDEELHKLIDAAQEQLTELRLSHWTQHEVFTPQWWFLLVLFLGSWLLWWRLLDKRRLYEIGFLGLFMAYLATLLDAAGSELQLWSYHYKLFPLYNRLLTADIALVPICYMLIYQWFPRWKPFLLAHAVLALGASFAAEPLFIWLGIYQPIVWKSYYSVPIYLLLAVMTKAMMKAIQKRYTKNTSPGR
>NC_016935.1|WP_014372367.1|7910911_7911232_-|hypothetical-protein
MSKLIYADESCYPPSEARGLSREEQYWLQFGLQHMEPEGLRGRYLSQLDHLEVAASCDCGEPTCVTVQFAGAGREQASRLVELELQDGRRLLIRHQQGRLAELELI
>NC_016935.1|WP_013920806.1|7921983_7922481_-|hypothetical-protein
MRDYLLYCSACHEYTALGKYIEKEGHFQGEYSLLHNSHTDSDELLCRFMIRHTGHELRLHTNRTEHFSRILRTASRFMEMDIDAFLERELDRKERMRSETEMERGLGQLQLNVLRQQLEEEAERIAGLPTSEAAESQFLLGKEEGVKRALAMLEELMERTRMMYR
>NC_016935.1|WP_014372377.1|7922549_7924166_-|chaperonin-GroEL
MAKHILFSEESRRAMLRGVDTLANAVKVTLGPKGRNVVLEKKFGSPLITNDGVTIAKEIELEDPFENMGAKLVKEVATKTNDVAGDGTTTATVLAQAMIREGLKNVTSGANPMVVRKGIDKAVRVAVDQILSTAKTVEQKHEIAQVAAISAADDTVGELIAEAMEKVGKDGVITVEESKGFQTELETVDGMQFDRGYISPYMITDSDKMEAVLDEPYVLITDKKISSLQDLLPVLEQVIKQGKPLLIVAEDVEGEALATLVVNKLRGAFTCVAVKAPGFGDRRKAMLQDLAVLTGGQVITDELGLDLKGASLDQLGRARQIHVTKENTTVVDGYGSRPEIEARVQQIRNLIEETTSDFDREKLQERLAKLAGGVAVIKVGAATETELKEKKLRIEDALNATRAAVQEGIVAGGGVALIHAIQAVEALTSEDSDEATGIRIVRHALEAPLRTIAANAGIDGSVVIERIKREPAGVGFNAATGEWVNMIESGIVDPAKVTRSALQHAASVASLFLTTECVVSDKPEPKKLGSGAGADMDM
>NC_016935.1|WP_014372378.1|7924158_7924473_-|co-chaperone-GroES
MLKPLGDRVVIEPLKQEEVTASGIVLPEKAKEKPMQGTVVAVGRGRMENGKVIPLDVREGDIVLYSKYGGTEIKAEGKELLIMRESDILAVLQPAGEKELVTNG
>NC_016935.1|WP_014372379.1|7924745_7925483_+|hypothetical-protein
MTIVLWLYLTLAGAGAAAGSGVPAAEPAGEAVLADGLPSAAELQALPLLAEGPGGLRLLAVEPSRSGMYPRLELHAGGISRAFEWSTADHPAYRPTLYRGNYDGDELPEIAVVLTQGYGSGVSVQELHVVNEEDLTELAVEHPVDAAASRVESEVTPRQDGTVHVSARTDGSLVRRTYSAGDAGSWLGEVHFGSIVKYRVDENRITALLPGQVSPAEFALIAEAEYGRDLRVQRILLREDTTASN
>NC_016935.1|WP_014372380.1|7926358_7927435_-|ABC-transporter-substrate-binding-protein
MKPLFRLFAAVFAAAFALMYLASYLNTSEGYTGENTLTVYNWGDYIDPELLTKFEEETGIKVIYQTFDSNEAMMTKISQGGTTFDVAVPSEYALSKMKDEGLLLPIDPVRLPNLKHINPRFLDLSFDPGNKYSVPYFWGTVGIIFNPDLLEEGKTFTSWNDLWDEKLENQILLVDGAREVMGMGLNSLGYSLNDRDEAHLQEAKAKLDTLTPNVKAIVGDEIKMLLANEEAAVGVVWSGDASEIMDENDKLDYVVPEEGSNLWFDNMVIPKTAHNIEGAHAFINFMLDPEVAAQNAEYVGYSTPNESAMEFLPEEISGDKRFYPDPELTEKLEVYENLGKRMLSHYNELFLEFKMHRK
>NC_016935.1|WP_013920812.1|7927431_7928244_-|ABC-transporter-permease
MKTRWKVSNLYLIAVFVILYAPILYLAYYSFNSGGSMHEFEGFTLEHYAEVFQDTRLLIIVLNTLVIALLSSALATIIGVAGALFIHRVRRHTTKQTLLTLNNVLIVSPDVVIGASFLILFTIAGIKLGFTSVLLSHIAFSVPIVVLMVLPKLQEMSPTLVDAAEDLGATRWDVLTKVVLPFIRPGIFAGFFMALTYSLDDFAVTFFVTGNGYATLAVEIYSRARQGVSLSINALSTLIFLFTLLLVLGYYAVNRRGAAKAKTLAEGVRP
>NC_016935.1|WP_014372381.1|7928240_7929053_-|ABC-transporter-permease
MGTNAATRSAYLIPYLLWMVLFVAAPIVLIAYYSFFDVDGNFTLGNYAKFFTPVYWRMALSSFWYALLITLFSLLVAYPAAYLLTKTRHKQLWLLLIILPTWINLLLKVYAFLGIFGTYGTVNKLLELLGIGTQQILFTDFSFVFVSVYIFIPFMILPIFNALEELNPSLVDASRDLGASAWTTFSRVIFPLTLGGVKAGCQAVFIPALSLFMITRLVAGNRVITLGTAIEQHFLVTQDWGIGATIAVFLILAMAVIMRLTGLRKRGGIV
>NC_016935.1|WP_014372382.1|7929042_7930149_-|ABC-transporter-ATP-binding-protein
MSDPTIIRFDRVTQRYDDQTTVLDNVSFEIRRGKFYTLLGPSGCGKTTILRLIAGFLQPTEGSISFNGKLINQVPANKRQVNTVFQDYALFPHLNVFENVAFGLRVKKMKNEDITRNVKEALRFVNLDGYESREITEMSGGQRQRVAIARAIVNEPEILLLDEPLSALDLKLRTEMQYELRELQRRLGITFIFVTHDQEEALAMSDEIFVLDKGRIQQSGTPTDIYDEPINRFVADFIGESNIVGGRMIRDYLVEFNGRRFECVDGGFRPNEEVEIVIRPEDLEITAADQGKVKVRVDSQLFRGVHYEISCYDDGGSEWLVHSTKKAAVGGEIGLQFDPGAIHVMRFGETEEEYDKRLAAYQADRDGD
>NC_016935.1|WP_014372383.1|7930400_7931462_-|hypothetical-protein
MKKSLAVLTVAAAVLASVPTSLNVSAAAPTGLEGVQILPSTTDHSTEKVKELVQKGRQVSADNALKRAAKLGVSAQADAAEKDAVNYLLIEGGTHYLYEKNGLDGAEKVYVYEQAPEAQAAAVKAKGRVTAAAVNLPDGIGGKAIVAKNGSYMNATVRTATAAQLTGAPSGATYIYGGFSGVGKGSNGSTSYPVEADMGLQYSNAYGYVKWTPILSYYNGVKSNGSFLSSYNQVQYKNGFKGGVDLNLTTYRNYNGNTRLSISGTAECPDMACTSQTDTYLTSVMEVAGTNVSSVTKWKMLATIAGSETVTGKNYAQFKNVNVDGVSQTPTIEAQDYATVTVSGSTVTINVSR
>NC_016935.1|WP_014372384.1|7931658_7933266_-|response-regulator
MKLLIVEDEPRLRMSLVYHIPWEERGIEVIASASGGEEALSLIVRRRPDLMLLDIQMPDMDGLTLARLVREKEPGMAMVILSGHDNFHFAQMALELGVFKYLLKPAGDTEILEAVTEAASHLRRQREESHEQALVEYKWHQHLPYLQNLFLLNWLKGRYRAEEIGRHASELQLNLPPEGRFAVAVFNPDERTESGEALRARDASVLEYTLGRIAKEHLQEGKYWICSDTPGSAVILFALPEGVEGQEGLLRIYTDVERILTLLGSFLSVSSSAGISGTTGKADGVYELYQQACIALLQRKIYGGGLAIPYREAVQPQTAVPVPEPACEKALEVALQTGDRIKAREALEALWNAAMGQGTADPEQVHEQVLYFSSLLVRTVRRQGWLLKDAAGSHYPYFQNIHLLTTAKQIHNWLCGTVERILDYAEEQGSQVNHRTVKLILELVEKELDQDLTLHALADRLYVNASYLSRLFKQEIGKPFSVYVLERKMERAKAALTEGAKVYDAALLAGYRDVSYFTKVFRRYWGTTPGTMKTC

Crispr_ID: NC_016935_22

• CRISPR_ID: NC_016935_22
• CRISPR_location: 8087471-8087546
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_016935_22

Consensus_repeat	Method
AATAGCGCATCGGAGTTCCGCTAT	CRISPRCasFinder

spacers of NC_016935_22

>22.1|8087495|28|NC_016935|CRISPRCasFinder
TTCGACCAACACACTCGCCAATTGAGCG

CRISPR arrays and Neighbor proteins around NC_016935_22

CRISPR arrays

The CRISPR arrays of NC_016935_22

>merge|NC_016935|22|8087471-8087546|CRISPRCasFinder
AATAGCGCATCGGAGTTCCGCTATTTCGACCAACACACTCGCCAATTGAGCGAATAGCGAATCGGAGTTCCGCTAT

>NC_016935|22|17|8087471-8087546|CRISPRCasFinder
AATAGCGCATCGGAGTTCCGCTAT	TTCGACCAACACACTCGCCAATTGAGCG
AATAGCGAATCGGAGTTCCGCTAT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016935.1|WP_013920978.1|8093723_8095019_-|adenylosuccinate-lyase	unknown	unknown	gnl|CDD|176464
NC_016935.1|WP_041619346.1|8075175_8076156_-|iron-siderophore-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|238566
NC_016935.1|WP_013920974.1|8089469_8091716_-|phosphoribosylformylglycinamidine-synthase-subunit-PurL	unknown	unknown	gnl|CDD|234921
NC_016935.1|WP_014372466.1|8076483_8077491_+|iron-ABC-transporter-permease	unknown	unknown	gnl|CDD|376439
NC_016935.1|WP_013920965.1|8078581_8079409_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224045
NC_016935.1|WP_013920982.1|8098270_8099113_+|hypothetical-protein	unknown	unknown	gnl|CDD|270620
NC_016935.1|WP_013920969.1|8083049_8083778_-|IMP-cyclohydrolase	unknown	unknown	gnl|CDD|377923
NC_016935.1|WP_013920970.1|8083844_8085032_-|phosphoribosylaminoimidazolecarboxamide-formyltransferase	unknown	unknown	gnl|CDD|180841
NC_016935.1|WP_013920975.1|8091693_8092389_-|phosphoribosylformylglycinamidine-synthase-subunit-PurQ	unknown	unknown	gnl|CDD|235140
NC_016935.1|WP_013920980.1|8096262_8096748_-|5-(carboxyamino)imidazole-ribonucleotide-mutase	unknown	unknown	gnl|CDD|376377
NC_016935.1|WP_013920976.1|8092435_8092681_-|phosphoribosylformylglycinamidine-synthase-subunit-PurS	unknown	unknown	gnl|CDD|376904
NC_016935.1|WP_014372472.1|8097169_8097862_-|hypothetical-protein	unknown	unknown	unknown
NC_016935.1|WP_013920977.1|8092796_8093690_-|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	unknown	unknown	gnl|CDD|133469
NC_016935.1|WP_013920983.1|8099275_8099977_+|polysaccharide-deacetylase-family-protein	unknown	unknown	gnl|CDD|213022
NC_016935.1|WP_014372467.1|8079713_8080949_-|glycosyl-transferase	unknown	unknown	gnl|CDD|273616
NC_016935.1|WP_014372470.1|8085654_8086698_-|phosphoribosylformylglycinamidine-cyclo-ligase	unknown	unknown	gnl|CDD|235439
NC_016935.1|WP_013920964.1|8077487_8078534_+|iron-ABC-transporter-permease	unknown	unknown	gnl|CDD|376439
NC_016935.1|WP_014372469.1|8085028_8085658_-|phosphoribosylglycinamide-formyltransferase	unknown	unknown	gnl|CDD|235544
NC_016935.1|WP_014372468.1|8081777_8083037_-|phosphoribosylamine--glycine-ligase	unknown	unknown	gnl|CDD|234856
NC_016935.1|WP_051045049.1|8087904_8089413_-|amidophosphoribosyltransferase	unknown	unknown	gnl|CDD|223112

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016935.1|WP_013920978.1|8093723_8095019_-|adenylosuccinate-lyase	gnl|CDD|176464	cd01360, Adenylsuccinate_lyase_1, Adenylsuccinate lyase (ASL)_subgroup 1. This subgroup contains bacterial and archeal proteins similar to ASL, a member of the Lyase class I family. Members of this family for the most part catalyze similar beta-elimination reactions in which a C-N or C-O bond is cleaved with the release of fumarate as one of the products. These proteins are active as tetramers. The four active sites of the homotetrameric enzyme are each formed by residues from three different subunits. ASL catalyzes two steps in the de novo purine biosynthesis: the conversion of 5-aminoimidazole-(N-succinylocarboxamide) ribotide (SAICAR) into 5-aminoimidazole-4-carboxamide ribotide (AICAR) and, the conversion of adenylsuccinate (SAMP) into adenosine monophosphate (AMP).	0
NC_016935.1|WP_041619346.1|8075175_8076156_-|iron-siderophore-ABC-transporter-substrate-binding-protein	gnl|CDD|238566	cd01146, FhuD, Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA-like protein is comprised of two globular subdomains connected by a long alpha helix and binds its specific ligands in the cleft between these domains.	2.42498e-95
NC_016935.1|WP_013920974.1|8089469_8091716_-|phosphoribosylformylglycinamidine-synthase-subunit-PurL	gnl|CDD|234921	PRK01213, PRK01213, phosphoribosylformylglycinamidine synthase subunit PurL.	0
NC_016935.1|WP_014372466.1|8076483_8077491_+|iron-ABC-transporter-permease	gnl|CDD|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	8.74638e-82
NC_016935.1|WP_013920965.1|8078581_8079409_+|ABC-transporter-ATP-binding-protein	gnl|CDD|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	1.80024e-128
NC_016935.1|WP_013920982.1|8098270_8099113_+|hypothetical-protein	gnl|CDD|270620	cd14667, 3D_containing_proteins, Non-mltA associated 3D domain containing proteins, named for 3 conserved aspartate residues. This family contains the 3D domain, named for its 3 conserved aspartates, including similar uncharacterized proteins. These proteins contain the critical active site aspartate of mltA-like lytic transglycosylases where the 3D domain forms a larger domain with the N-terminal region. This domain is also found in conjunction with numerous other domains such as the Escherichia coli MltA, a membrane-bound lytic transglycosylase comprised of 2 domains separated by a large groove, where the peptidoglycan strand binds. Domain A is made up of an N-terminal and a C-terminal portion, corresponding to the 3D domain and Domain B is inserted within the linear sequence of domain A. MltA is distinct from other bacterial LTs, which are similar to each other. Escherichia coli peptidoglycan lytic transglycosylase (LT) initiates cell wall recycling in response to damage, during bacterial fission, and cleaves peptidoglycan (PG) to create functional spaces in its wall. PG chains (also known as murein), the major components of the bacterial cell wall, are comprised of alternating beta-1-4-linked N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), and lytic transglycosylases cleave this beta-1-4 bond.	1.40426e-27
NC_016935.1|WP_013920969.1|8083049_8083778_-|IMP-cyclohydrolase	gnl|CDD|377923	pfam07826, IMP_cyclohyd, IMP cyclohydrolase-like protein. This enzyme may catalyze the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to inosine monophosphate (IMP), a reaction which is important in de novo purine biosynthesis in archaeal species. This single domain protein is arranged to form an overall fold that consists of a four-layered alpha-beta-beta-alpha core structure. The two antiparallel beta-sheets pack against each other and are covered by alpha-helices on one face of the molecule. The protein is structurally similar to members of the N-terminal nucleophile (NTN) hydrolase superfamily. A deep pocket was in fact found on the surface of IMP cyclohydrolase in a position equivalent to that of active sites of NTN-hydrolases, but an N-terminal nucleophile could not be found. Therefore, it is thought that this enzyme is structurally but not functionally similar to members of the NTN-hydrolase family.	1.4088e-75
NC_016935.1|WP_013920970.1|8083844_8085032_-|phosphoribosylaminoimidazolecarboxamide-formyltransferase	gnl|CDD|180841	PRK07106, PRK07106, phosphoribosylaminoimidazolecarboxamide formyltransferase.	0
NC_016935.1|WP_013920975.1|8091693_8092389_-|phosphoribosylformylglycinamidine-synthase-subunit-PurQ	gnl|CDD|235140	PRK03619, PRK03619, phosphoribosylformylglycinamidine synthase subunit PurQ.	7.44847e-155
NC_016935.1|WP_013920980.1|8096262_8096748_-|5-(carboxyamino)imidazole-ribonucleotide-mutase	gnl|CDD|376377	pfam00731, AIRC, AIR carboxylase. Members of this family catalyze the decarboxylation of 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR). This family catalyze the sixth step of de novo purine biosynthesis. Some members of this family contain two copies of this domain.	2.93203e-90
NC_016935.1|WP_013920976.1|8092435_8092681_-|phosphoribosylformylglycinamidine-synthase-subunit-PurS	gnl|CDD|376904	pfam02700, PurS, Phosphoribosylformylglycinamidine (FGAM) synthase. This family forms a component of the de novo purine biosynthesis pathway.	1.50974e-38
NC_016935.1|WP_013920977.1|8092796_8093690_-|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	gnl|CDD|133469	cd01414, SAICAR_synt_Sc, non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase. Eukaryotic, bacterial, and archaeal group of SAICAR synthetases represented by the Saccharomyces cerevisiae (Sc) enzyme, mostly absent in metazoans. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.	6.62936e-139
NC_016935.1|WP_013920983.1|8099275_8099977_+|polysaccharide-deacetylase-family-protein	gnl|CDD|213022	cd10917, CE4_NodB_like_6s_7s, Catalytic NodB homology domain of rhizobial NodB-like proteins. This family belongs to the large and functionally diverse carbohydrate esterase 4 (CE4) superfamily, whose members show strong sequence similarity with some variability due to their distinct carbohydrate substrates. It includes many rhizobial NodB chitooligosaccharide N-deacetylase (EC 3.5.1.-)-like proteins, mainly from bacteria and eukaryotes, such as chitin deacetylases (EC 3.5.1.41), bacterial peptidoglycan N-acetylglucosamine deacetylases (EC 3.5.1.-), and acetylxylan esterases (EC 3.1.1.72), which catalyze the N- or O-deacetylation of substrates such as acetylated chitin, peptidoglycan, and acetylated xylan. All members of this family contain a catalytic NodB homology domain with the same overall topology and a deformed (beta/alpha)8 barrel fold with 6- or 7 strands. Their catalytic activity is dependent on the presence of a divalent cation, preferably cobalt or zinc, and they employ a conserved His-His-Asp zinc-binding triad closely associated with the conserved catalytic base (aspartic acid) and acid (histidine) to carry out acid/base catalysis. Several family members show diversity both in metal ion specificities and in the residues that coordinate the metal.	4.86761e-77
NC_016935.1|WP_014372467.1|8079713_8080949_-|glycosyl-transferase	gnl|CDD|273616	TIGR01426, Glycosyl_transferase, glycosyltransferase, MGT family. This model describes the MGT (macroside glycosyltransferase) subfamily of the UDP-glucuronosyltransferase family. Members include a number of glucosyl transferases for macrolide antibiotic inactivation, but also include transferases of glucose-related sugars for macrolide antibiotic production. [Cellular processes, Toxin production and resistance].	4.77048e-117
NC_016935.1|WP_014372470.1|8085654_8086698_-|phosphoribosylformylglycinamidine-cyclo-ligase	gnl|CDD|235439	PRK05385, PRK05385, phosphoribosylaminoimidazole synthetase; Provisional.	0
NC_016935.1|WP_013920964.1|8077487_8078534_+|iron-ABC-transporter-permease	gnl|CDD|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	6.48878e-83
NC_016935.1|WP_014372469.1|8085028_8085658_-|phosphoribosylglycinamide-formyltransferase	gnl|CDD|235544	PRK05647, purN, phosphoribosylglycinamide formyltransferase; Reviewed.	6.74124e-105
NC_016935.1|WP_014372468.1|8081777_8083037_-|phosphoribosylamine--glycine-ligase	gnl|CDD|234856	PRK00885, PRK00885, phosphoribosylamine--glycine ligase; Provisional.	0
NC_016935.1|WP_051045049.1|8087904_8089413_-|amidophosphoribosyltransferase	gnl|CDD|223112	COG0034, PurF, Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism].	0

Protein sequences

>NC_016935.1|WP_014372470.1|8085654_8086698_-|phosphoribosylformylglycinamidine-cyclo-ligase
MSDAYKQAGVDIAAGNEAVERMKKHVKTTFRPEVLTELGGFGGLFGLNKDKYEEPVLVSGTDGVGTKLKLAFAMDKHDTIGIDAVAMCVNDIIVQGAEPLFFLDYLACDKVIPEKIEAIVKGISDGCVQAGCALIGGETAEMPGMYSEGEYDIAGFTVGIVDKKKIIDGSTIRPGDVVLGLPSSGIHSNGFSLVRRLLLEQKGYKLDQALEALEGKKLGDVLIEPTRIYVKTILSLLEKVQIKGMAHITGGGFLENIPRVLPKNVNAHIQYGSWPILPIFHLMQQDGSISNNDMFRTFNMGIGMVIVVSAEEAEATLAAARELGESIYRLGEITTGEGIVTFEGAEV
>NC_016935.1|WP_014372469.1|8085028_8085658_-|phosphoribosylglycinamide-formyltransferase
MIERLRIAVFASGSGSNFQALTDAVQSGKLDADIELLVCDKPEAPVVQRAEAAGVETFLFRPKDYPSREAYEAEILERLRDKKIGLVVLAGYMRILTHVLVDAYWGRMINVHPSLLPSFPGLHAVRQALNHGVKITGVTVHIVDGGLDSGPILAQRALVIGPEDTEETLAERIHEIEHELYPQVVQAIADGSIKLDDIATSKEKDGMKS
>NC_016935.1|WP_013920970.1|8083844_8085032_-|phosphoribosylaminoimidazolecarboxamide-formyltransferase
MSQTTNQKHEIELRYGMNPHQKQAKLISEGNLPITVVNGDPGFINLLDALNGFQLARELRRATGLPAAASFKHVSPAGAAVAAPLTPELAKAYFVEGLELSPLATAYARARGADRMSSFGDAVALSDVVDASTALLLKREVSDLVVAPGYTPEALEILKAKKNGGYLMLQIDPEYVPNPVETRTLFGLTLQQERNDAVIDASALERIVTENKDLPDNAKRDLLIALVTLKYTQSNSICYTLDGQTIGIGAGQQSRIHCTRLAGDKADRWYLRQHPTALNMKFRQGLSRAEQNNAIDLWLEEELTPVEQAAWEAAFEEVPARLTREEKREWLKGLQGVSYGSDAFLPFRDNLDRASRSGVKYVVQAGSSMRDEEVVKAANDYGMVMCYSGVRLFHH
>NC_016935.1|WP_013920969.1|8083049_8083778_-|IMP-cyclohydrolase
MTTRAAQAERYLNSLKENVYPGRGIVIGQTPDGSKLVQVYWIMGRSENSRNRVFIQEDNGFLRTEAKDPAKLTDPSLIIYYPVKHLGGAHIVTNGDQTDTIHEALQQGGTFESALASRTYEPDAPNFTPRISGLVDLADEQFAYKLSILKSSGNTEDQTLRYTFTYEKALPGYGHCIHTYAGDGNPLPSFQGEPQLVPLANDAQTIAETYWNALNEENRISLLVKTISLETAEAELLVINKE
>NC_016935.1|WP_014372468.1|8081777_8083037_-|phosphoribosylamine--glycine-ligase
MRVLVVGGGGREHAICWALKKSPKVQELYCAPGNGGIASVAECVPIGVHQFEEIGQFALDKNIDLVVIGPDDPLAAGIVDHLERKNLKVFGPRENAAIIEGSKVFTKQLLKKYSIPTAAYESFEQYDAAAAYLDQLKAPYVIKADGLAAGKGVIIAQSKEEAETALREIMVDKIFGESGNQVVIEEFLTGQEMSILAFVDGETVKPMTPAQDHKPVFDGDKGPNTGGMGTYTPLPHIPQSIIDEAIETIVKPTAKAMVSEGRPFRGVLFAGLMITPDGPKTIEFNARFGDPETQVVLPRLQTDLLEIFLATVEGRLEEIDIQWSDEAAVCVILASEGYPGSYPKGLPIEGLESVQDAIVFHAGTAIKDGAVVTNGGRVLGVTALGRDIAEARSKAYAAADGIHFAGKHNRTDIAKKALV
>NC_016935.1|WP_014372467.1|8079713_8080949_-|glycosyl-transferase
MAHVLMINLPAEGHVNPTVGLVKELTARGERVTYYCTEDFKERLEGAGAVVRTYKNYHQELMGAGRPGAEGFDARQMMNFMLHGAELMVKGILPEVRQESYDYVIYDSMCVAGWIIADILGLPKVCSSTTFMIGEEMQERMPALMKERFQPDRDSELYLKSQEPVKRMEQEYGLDLSSLQSVPGIVSHPGDLSVVFTSRMFQIAGERFDDTHRFVGPSIAKRADSGDFPFDELEGHTVIYISLGTVFNEMKGFYQACFDAFRDAEAKVVLSVGRKINLEELPEPPANFIVRPYVPQLEVLQHADVFFTHGGMNSTSEGLYYGVPLAVLPVSADQPMVAGRVAEFGAGIALDHSKVTPELLRETAEKLLGEASYKEKAEQIAASFREAGGASRAAEDILSWSRTLQPQVPQG
>NC_016935.1|WP_013920965.1|8078581_8079409_+|ABC-transporter-ATP-binding-protein
MTAIQSKDLCLCYGETCIFQELSIRIPKGKVTVFIGSNGCGKSTLLRSLARLLKPQKGSIVLDGNEISRMSTKEIARRMAMLPQGPAAPDGLTVLQLVKQGRYPYQNWLQQWSKEDETMVQRALELTNMAPLAERTVDSLSGGQRQRAWIAMTLAQGTPTILLDEPTTYLDLAHQIEVLDLLYELNEREQRTIVMVLHDINLACRYADNIVAIKDRKVWAEGRPEDIVNEKLIKDVFDLESKVIEDPLFGTPMIVPVGKGKRPAAGKLPVRPVAL
>NC_016935.1|WP_013920964.1|8077487_8078534_+|iron-ABC-transporter-permease
MNRKSRYMTLRGSAYSFLISRRAVLITVLLLIALLAAVVLCTGIGSVFIPPAEVIRAILGTGTDASETIVRSLRLPRIVIGVLIGAALAVSGAILQGVVRNPLASPDTIGVTGGATLGAVSFFFFLTERVSIAWLPVAAIAGAFLAMVLVYGLSWKNGVTPLRLVLIGIGFSAAMSSLSHMMMLTGPVVVANKALTFMTGSIYGVSWEKDVLILLPYVVVLLPLVLLYSRHINIQELGEEIALSVGSAVQRQRLLLLLFSVALAGAAGAFGGAITFIGLMAPHMARKLVGPSFGALLPVSALLGALILLGADLVGRTAFSPLDIPAGVFTAAIGAPFFVYLLYRSRNR
>NC_016935.1|WP_014372466.1|8076483_8077491_+|iron-ABC-transporter-permease
MHNERSLAFKVTWLLVSAIVLALVMLSSVMFGIQTYSWEQIVSAYSRFDGSNEHLIITTARMPRALIAAAVGASLAVAGALMQAITRNPLASPSVFGVNAGAAFAIVLSVTVWNASSLSEFVWIAFAGAAISSLAVYVLGSIGRDGLTPMKITLAGSAISAFFASLTQGLLLGSGKAFDQVLFWLVGSVAGRTMEMLHSVLPYMAAAMVGALLLASHINVLSMGEDVAKGLGQRTILIKALTALVIVLLAGGSVAVAGPIVFVGIIVPHIVRFVVGIDHRWVLPYCAVFGALLLTGADVGARFIAMPKEVHVGVTTAIIGVPFFVYIARKGGQLR
>NC_016935.1|WP_041619346.1|8075175_8076156_-|iron-siderophore-ABC-transporter-substrate-binding-protein
MIGKKSSLLLALVMMLSVFLTACGSKPAEQAAPSTAGGTENKTAAEGPRKIKHVMGETEVPAAPKRVVILTNEGTEALLSLGIKPVGAVKSWTGSPWYDHIKSEMEGVTVVGEESQPNLELIASLKPDLIIGNKMRQEKVYDQLKAIAPTVFSETLRGEWKNNYRLYAETVGKKDEGEKVIADFDKRIADIKAKAGDKLNQKVSVVRFMAGKTRIYLQDTFTGIIFNQLGIKRPENKYKDTFVEEITKERLPEVDADMLFYFTYETGDNKASQQEQDWLNDALWKNLNVVKAGKVHKVNDAIWNTAGGVKAANLLLDDLAKIYEIK
>NC_016935.1|WP_051045049.1|8087904_8089413_-|amidophosphoribosyltransferase
MRQGGNGQGQHDGAFPLWTGAYYNEGMGAGPNGLSDKLGEECGVFGVFGHPEAANLSYYGLHALQHRGQESSGICVAGEDAFNYHRGMGLVKEVFNNDNLGPMVGSYAIGHVRYSTAGESKLANAQPLVFKYREGDLAIATNGNLTNAPDIKKRLEREGSIFQTTSDTEVVAHLIARSKHDDIVEAVRDALLQIEGAYAFLFLTRDKLIAARDPHGLRPFVMGRLGDAYLFASESCAFDTVGGLYERDIQPGELLILNQRTGELTHDRFAEGKQRAVCAMEYIYFARPDSDIDEVNIHSARKRMGRQLAIESFVDADIVTGVPDSSISAAIGYAEQTGIPYELGLIKNRYTGRTFIQPSQELREQGVKMKLSAVRSIVHGKRVVMIDDSIVRGTTSLRIVNMLREAGATEVHVRISSPPFQNPCFYGIDTPNRGELIAAVKSVEEIRKAINADSLHFLSQEGLVNSIGGPAGEINRGHCTACFDNRYPTAIPDDAKIGCGCD
>NC_016935.1|WP_013920974.1|8089469_8091716_-|phosphoribosylformylglycinamidine-synthase-subunit-PurL
MAQQLSAKEPTAEQIQEQKIYKQFGVSDAEYDLICGFLGRKPNYVEIGVFSVMWSEHCSYKNSKAVLRKFPTTGERVLMGPGEGAGIVDIGDNQAVVFKIESHNHPSAVEPYQGAATGVGGIIRDIFSMGARPVAVLNSLRFGRLTNDRVKYLFEHVVSGIAGYGNCIGIPTVGGEVMFDESYEGNPLVNAMCVGIIDHDKIQKGVAKGVGNPVFYVGPATGRDGIHGATFASEDLTAESEAKRSAVQVGDPFMEKLVLEACLELIDSGIVVGIQDMGAAGLTCSSSEMASKAGNGMELYLDEVPQREEGMTPYEMMLSESQERMLFVVKPEHEEQAKAIFERWGLHCAKVGKVTDDGNLKLYHKGELVGDMPVTALVDECPMYNKPSSVPAYYEANASVDTTAYPEVTDLNGALKQVLASPTVASKEWVYNQYDYMVRTSTAVQPGSDAAVVTIRGSRKALSMSTDCNGRYVYLDPEVGGKIAVAEAARNNVCSGAEPLAITDNLNFGSPEKPEIFWQLEKSVDGMAEACRKLNTPVIGGNVSLYNENARGAIYPTPVVGMVGLVHDTDHITTQGFKNEGDIVLLLGETKAELGGSEFQYVVHGVTEGRPPQIDLDVEKTLLDTVLGAIQKGLVASAHDLSDGGLAVALAESCISGRLGANVNLTTDLRADIALFSESQSRLLLSAAPEKASELEAVLKAAGVPVQVIGKVEGTSLQVQVNGSAAIDAAVAELQQVWKDAIPCLMNA
>NC_016935.1|WP_013920975.1|8091693_8092389_-|phosphoribosylformylglycinamidine-synthase-subunit-PurQ
MNFAVLVFPGSNCDIDCYKAVEDTVGQPVDYVWHTETDLSKYDCIIIPGGFSYGDYLRCGAIAQFAPVMKALREAAEQGKYILGICNGFQILLESGLLPGAMLRNESLKFRCHAAMLSVVNTDTPFTKEYKQDELINIPIAHGEGNYYCDEAALAELKANNQIVFRYEAGNNPNGSVDDIAGICSKGGNVLGMMPHPERAVSALLGSEDGKRMFTSILSTWREKHGAAAIG
>NC_016935.1|WP_013920976.1|8092435_8092681_-|phosphoribosylformylglycinamidine-synthase-subunit-PurS
MLKATVYVTIKQSVLDVQGTAVQGALHSMGFDEVDKVRIGKYLEVELNTDNRAAAEERLKAMCEKLLANTVIEDYRYELSE
>NC_016935.1|WP_013920977.1|8092796_8093690_-|phosphoribosylaminoimidazolesuccinocarboxamide-synthase
MKEASTIAISSAQEYIKAPLLYKGKVREIYGLGDHYLIAVSDRISAFDWVLSPAVPDKGNVLNTLSKFWFDQTTEIIDNHVVHTDVDLLGDIITDREIMKDRFMVTKKAERIDIECVVRGYITGGGWRQYQQTGEINGHKLPAGLRKNQRFEQPIFTPAAKNDVGHDEDISIERMKELVGAELTEQLQAKSLQLYNYAHAFCQDRGIILADTKFEFGLIDGEIILIDEIFTPDSSRFWAKDKYELDTEIDSMDKEPVRSYLASTDWDKNSEPAPLPAEVVEETSRRYREIYNRLVLG
>NC_016935.1|WP_013920978.1|8093723_8095019_-|adenylosuccinate-lyase
MIDRYTRPEMGSIWTEENKFKAWLEVEILSCEAWAELGVIPKEDVAELRKNASFDIDRIYEIEQETRHDVIAFTRAVSEKVGPERKWVHYGLTSTDVVDTALGYLLRQANEIIERDIVNFIEILKDKAVAYKDTPMMGRTHGVHAEPTTFGLKMALWYEEMKRNLERFRFAADGVQFGKISGAVGTYANIDPFIEEYVCGKLGTKPAPISTQTLQRDRHAEYMATLALIATSLDKFATEIRALQKSEFREVEEPFAKGQKGSSAMPHKRNPIGCESISGLARVIRGHMVSAYENVTLWHERDISHSSVERIILPDSTILLNYMLNRLGNIIKNLTVFPENMKRNMQSTYGVPFSGRVMTKLIDKGLSREQAYDTVQPRAMQAWEEQRSFRDIVENTPAIREYLSLEEIEDAFNPSWHLKHVDTIFKRLGLS
>NC_016935.1|WP_013920980.1|8096262_8096748_-|5-(carboxyamino)imidazole-ribonucleotide-mutase
MSVLVGVIMGSQSDWETMKKACDVLDELGVAYEKKVVSAHRTPDLMFEYAETAAERGLKVIIAGAGGAAHLPGMVASKTVLPVIGVPVKTSTLNGLDSLLSIVQMPGGIPVATVAIGQAGATNAGLLAAQILGAFDGGIQQRVAERRERIAKSVMESSVLE
>NC_016935.1|WP_014372472.1|8097169_8097862_-|hypothetical-protein
MYQRDYILRMIEQAGVIVGRVMHLARNKRMQEAIELLQQAMKEMLGLGSKLIGALSVKDLIALLSKDGELDSAKVLALGDLMKAQSELQREGGEEAAAQRTARKSLELLLIGREYDARGELREEFNRRIQEALDITGRAGLNEGILSRIVGYYEEQGSYAWAEDALFYRLEVLQGGERELEWRAAVEEGIRMYERWVLLEDTPLRAGGLSAEEAEEGLRTLRQLKITQSQ
>NC_016935.1|WP_013920982.1|8098270_8099113_+|hypothetical-protein
MNSRITSMLKACLLTLPAAAILVFASPAQAETVRLAEDIKVQVNSSLVHFPDAQPFLDENHKLQVPARVMADKLGYQLQWEHAGAQMKVTLSSSTTTVVFTTGDPNITVNGQPSVQEAAAKLVDGRAYVPFRMLADSFSIQTQWDNLNRIAILGVDGQYHAPAWYRPTKIAPLYTKTIEARASAYTAAAAENGTFAARDYMGNPLKLGTIAVDPAVIPLGSKVFIEGYTHDGLPVGGMYAVATDIGGSVKGNKIDIFMPQGRHAALQFGIQNVKVHVLGS
>NC_016935.1|WP_013920983.1|8099275_8099977_+|polysaccharide-deacetylase-family-protein
MNQGVRRLLLCVLTTFCLTGAAAPAPRPSEVVWNVETDQKLIALTFDDGPNPVYTPQILDLLHEYGAKGTFFVIGKRVQLYPAIAIREVNEGHEIANHTFDHHFLKHYPAERLITEIRQTQEVIFDITEQMPHVFRPPGGYYNDALLQSMKEDKLTVVMWSWYQDTKDWMKPGVDKIVAQVLNNVHNGDIILFHDLQGDCSQTVEALRRILPELKQRGYEFVTVSDLISRTRK

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_016935_16	16.1|6978457|27|NC_016935|CRISPRCasFinder	6978457-6978483	27	NC_016935.1	3025141-3025167	1	0.963
NC_016935_16	16.1|6978457|27|NC_016935|CRISPRCasFinder	6978457-6978483	27	NC_016935.1	3090267-3090293	1	0.963
NC_016935_17	17.1|7271880|18|NC_016935|CRT	7271880-7271897	18	NC_016935.1	5614375-5614392	1	0.944
NC_016935_1	1.3|395411|27|NC_016935|CRT	395411-395437	27	NC_016935.1	395523-395549	2	0.926

1. spacer 16.1|6978457|27|NC_016935|CRISPRCasFinder matches to position: 3025141-3025167, mismatch: 1, identity: 0.963

tcgactatttcccatcatttcccgaag	CRISPR spacer
tcggctatttcccatcatttcccgaag	Protospacer
***.***********************

2. spacer 16.1|6978457|27|NC_016935|CRISPRCasFinder matches to position: 3090267-3090293, mismatch: 1, identity: 0.963

tcgactatttcccatcatttcccgaag	CRISPR spacer
tcgagtatttcccatcatttcccgaag	Protospacer
**** **********************

3. spacer 17.1|7271880|18|NC_016935|CRT matches to position: 5614375-5614392, mismatch: 1, identity: 0.944

cccgagcttctccgccgt	CRISPR spacer
cccgagctcctccgccgt	Protospacer
********.*********

4. spacer 1.3|395411|27|NC_016935|CRT matches to position: 395523-395549, mismatch: 2, identity: 0.926

aaccgccggcctgacgctccacagccc	CRISPR spacer
aaccgccggcttgacactccacagccc	Protospacer
**********.****.***********

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_016935_10	10.1|3667759|26|NC_016935|CRISPRCasFinder	3667759-3667784	26	MK733259	Yersinia phage YeP1, complete genome	13094-13119	4	0.846
NC_016935_10	10.1|3667759|26|NC_016935|CRISPRCasFinder	3667759-3667784	26	MK733261	Yersinia phage YeP3, complete genome	13105-13130	4	0.846
NC_016935_10	10.1|3667759|26|NC_016935|CRISPRCasFinder	3667759-3667784	26	MK733260	Yersinia phage YeP2, complete genome	13105-13130	4	0.846
NC_016935_13	13.1|6674036|26|NC_016935|CRISPRCasFinder	6674036-6674061	26	NC_019428	Anabaena sp. 90 plasmid pANA01, complete sequence	31867-31892	4	0.846
NC_016935_13	13.3|6674149|26|NC_016935|CRISPRCasFinder	6674149-6674174	26	NZ_CP047963	Aeromonas media strain MC64 plasmid pMC64A, complete sequence	66787-66812	4	0.846
NC_016935_1	1.1|395299|27|NC_016935|CRT	395299-395325	27	NZ_CP026382	Sphingopyxis sp. MG plasmid pCMS1, complete sequence	2566-2592	5	0.815
NC_016935_1	1.1|395299|27|NC_016935|CRT	395299-395325	27	NZ_CP053441	Rhizobium leguminosarum bv. trifolii strain CC275e plasmid pRltCC275eE, complete sequence	191419-191445	5	0.815
NC_016935_1	1.3|395411|27|NC_016935|CRT	395411-395437	27	NZ_CP054618	Azospirillum oryzae strain KACC 14407 plasmid unnamed4, complete sequence	123752-123778	5	0.815
NC_016935_1	1.3|395411|27|NC_016935|CRT	395411-395437	27	NC_016655	Rhodococcus phage REQ1, complete genome	5019-5045	5	0.815
NC_016935_8	8.1|3256452|28|NC_016935|CRISPRCasFinder	3256452-3256479	28	NZ_CP014361	Methylomonas sp. DH-1 plasmid, complete sequence	6158-6185	5	0.821
NC_016935_8	8.1|3256452|28|NC_016935|CRISPRCasFinder	3256452-3256479	28	NZ_CP023670	Methylomonas koyamae strain LM6 plasmid pLM6, complete sequence	35628-35655	5	0.821
NC_016935_21	21.1|7921143|27|NC_016935|CRISPRCasFinder	7921143-7921169	27	NZ_CP046723	Pantoea agglomerans strain ASB05 plasmid pASB05p1, complete sequence	548289-548315	5	0.815
NC_016935_21	21.1|7921143|27|NC_016935|CRISPRCasFinder	7921143-7921169	27	NZ_CP016890	Pantoea agglomerans strain C410P1 plasmid unnamed1, complete sequence	503288-503314	5	0.815
NC_016935_21	21.1|7921143|27|NC_016935|CRISPRCasFinder	7921143-7921169	27	NZ_CP045721	Pantoea eucalypti strain LMG 24197 plasmid unnamed1, complete sequence	191544-191570	5	0.815
NC_016935_21	21.1|7921143|27|NC_016935|CRISPRCasFinder	7921143-7921169	27	NZ_CP034470	Pantoea agglomerans strain CFSAN047153 plasmid pCFSAN047153_1, complete sequence	203906-203932	5	0.815
NC_016935_21	21.1|7921143|27|NC_016935|CRISPRCasFinder	7921143-7921169	27	NZ_CP034149	Pantoea agglomerans strain L15 plasmid pPagL15_1, complete sequence	563989-564015	5	0.815
NC_016935_21	21.1|7921143|27|NC_016935|CRISPRCasFinder	7921143-7921169	27	NC_014258	Pantoea vagans C9-1 plasmid pPag3, complete sequence	23288-23314	5	0.815
NC_016935_21	21.1|7921143|27|NC_016935|CRISPRCasFinder	7921143-7921169	27	NZ_CP043960	Streptomyces tendae strain 139 plasmid unnamed1, complete sequence	79671-79697	5	0.815
NC_016935_21	21.1|7921143|27|NC_016935|CRISPRCasFinder	7921143-7921169	27	NZ_CP014127	Pantoea vagans strain FDAARGOS_160 plasmid unnamed2, complete sequence	78894-78920	5	0.815
NC_016935_21	21.1|7921143|27|NC_016935|CRISPRCasFinder	7921143-7921169	27	NZ_CP028350	Pantoea vagans strain PV989 plasmid pPV989-508, complete sequence	26284-26310	5	0.815
NC_016935_21	21.1|7921143|27|NC_016935|CRISPRCasFinder	7921143-7921169	27	NZ_CP034475	Pantoea agglomerans strain CFSAN047154 plasmid pCFSAN047154_1, complete sequence	602845-602871	5	0.815
NC_016935_21	21.1|7921143|27|NC_016935|CRISPRCasFinder	7921143-7921169	27	NZ_CP038854	Pantoea vagans strain LMG 24199 plasmid unnamed1, complete sequence	499965-499991	5	0.815
NC_016935_21	21.1|7921143|27|NC_016935|CRISPRCasFinder	7921143-7921169	27	NZ_CP022517	Pantoea vagans strain FBS135 plasmid pPant1, complete sequence	195272-195298	5	0.815
NC_016935_1	1.3|395411|27|NC_016935|CRT	395411-395437	27	NC_022242	Achromobacter xylosoxidans subsp. denitrificans pAX22 plasmid, complete sequence	27255-27281	6	0.778
NC_016935_1	1.3|395411|27|NC_016935|CRT	395411-395437	27	LC155906	Achromobacter xylosoxidans plasmid pKUN4507_1 DNA, complete sequence, strain: KUN4507	13746-13772	6	0.778
NC_016935_1	1.3|395411|27|NC_016935|CRT	395411-395437	27	NZ_CP026223	Aeromonas sp. ASNIH3 plasmid pAER-3367, complete sequence	9583-9609	6	0.778
NC_016935_1	1.3|395411|27|NC_016935|CRT	395411-395437	27	NC_020452	Pseudomonas aeruginosa strain COL-1 plasmid pNOR-2000, complete sequence	2315-2341	6	0.778
NC_016935_1	1.3|395411|27|NC_016935|CRT	395411-395437	27	NZ_MF168945	Pseudomonas aeruginosa strain FFUP_PS_35 plasmid pJB35, complete sequence	18272-18298	6	0.778
NC_016935_1	1.3|395411|27|NC_016935|CRT	395411-395437	27	NZ_MF141039	Pseudomonas aeruginosa strain PAcoop101 plasmid pCOOP-101, complete sequence	1069-1095	6	0.778
NC_016935_1	1.3|395411|27|NC_016935|CRT	395411-395437	27	NZ_MF564290	Pseudomonas putida strain KSS435 plasmid pVIM_Pse-KSS435, complete sequence	13371-13397	6	0.778
NC_016935_8	8.1|3256452|28|NC_016935|CRISPRCasFinder	3256452-3256479	28	NZ_KP342511	Enterococcus faecium isolate N12-493 plasmid pEfm12493, complete sequence	84750-84777	6	0.786
NC_016935_14	14.1|6828694|27|NC_016935|CRISPRCasFinder	6828694-6828720	27	NZ_CP031696	Erwinia billingiae strain TH88 plasmid unnamed1, complete sequence	18250-18276	6	0.778
NC_016935_16	16.1|6978457|27|NC_016935|CRISPRCasFinder	6978457-6978483	27	NZ_CP032306	Salmonella enterica subsp. enterica serovar Braenderup strain FORC93 plasmid unnamed2, complete sequence	21493-21519	6	0.778
NC_016935_21	21.1|7921143|27|NC_016935|CRISPRCasFinder	7921143-7921169	27	NZ_CP013110	Sinorhizobium americanum strain CFNEI 73 plasmid C, complete sequence	1804192-1804218	6	0.778
NC_016935_9	9.12|3289281|30|NC_016935|PILER-CR	3289281-3289310	30	JQ768459	Pseudomonas phage Lu11, complete genome	230676-230705	7	0.767
NC_016935_9	9.12|3289281|30|NC_016935|PILER-CR	3289281-3289310	30	MN694663	Marine virus AFVG_250M439, complete genome	42895-42924	7	0.767
NC_016935_21	21.1|7921143|27|NC_016935|CRISPRCasFinder	7921143-7921169	27	NZ_CP015738	Shinella sp. HZN7 plasmid pShin-02, complete sequence	362291-362317	7	0.741
NC_016935_21	21.1|7921143|27|NC_016935|CRISPRCasFinder	7921143-7921169	27	NZ_CP016452	Sinorhizobium sp. RAC02 plasmid pBSY16_1, complete sequence	1688695-1688721	7	0.741
NC_016935_9	9.8|3289279|32|NC_016935|CRT	3289279-3289310	32	JQ768459	Pseudomonas phage Lu11, complete genome	230676-230707	8	0.75
NC_016935_9	9.12|3289281|30|NC_016935|PILER-CR	3289281-3289310	30	NZ_CP049158	Caballeronia sp. SBC1 plasmid pSBC1_2, complete sequence	1134762-1134791	8	0.733
NC_016935_9	9.12|3289281|30|NC_016935|PILER-CR	3289281-3289310	30	NZ_CP049318	Caballeronia sp. SBC2 plasmid pSBC2-2, complete sequence	1139442-1139471	8	0.733
NC_016935_9	9.2|3288940|32|NC_016935|CRT	3288940-3288971	32	CP007645	Rhizobium etli bv. phaseoli str. IE4803 plasmid pRetIE4803d, complete sequence	332193-332224	9	0.719
NC_016935_2	2.2|1008406|34|NC_016935|CRT	1008406-1008439	34	KT591491	Mycobacterium phage Bricole, complete genome	21885-21918	10	0.706
NC_016935_2	2.2|1008406|34|NC_016935|CRT	1008406-1008439	34	NC_021299	Mycobacterium phage PegLeg, complete genome	21898-21931	10	0.706
NC_016935_2	2.2|1008406|34|NC_016935|CRT	1008406-1008439	34	MN586024	Mycobacterium phage TyDawg, complete genome	21899-21932	10	0.706
NC_016935_2	2.2|1008406|34|NC_016935|CRT	1008406-1008439	34	MK937612	Mycobacterium phage LilhomieP, complete genome	21899-21932	10	0.706
NC_016935_2	2.2|1008406|34|NC_016935|CRT	1008406-1008439	34	MH697587	Mycobacterium phage IPhane7, complete genome	21899-21932	10	0.706
NC_016935_2	2.2|1008406|34|NC_016935|CRT	1008406-1008439	34	NC_041970	Mycobacterium phage Bongo, complete genome	21899-21932	10	0.706

1. spacer 10.1|3667759|26|NC_016935|CRISPRCasFinder matches to MK733259 (Yersinia phage YeP1, complete genome) position: , mismatch: 4, identity: 0.846

cgggctgatgtgaagcgcgatattcg	CRISPR spacer
cgtgctgatgtgaatcgcgatatcag	Protospacer
** *********** ********. *

2. spacer 10.1|3667759|26|NC_016935|CRISPRCasFinder matches to MK733261 (Yersinia phage YeP3, complete genome) position: , mismatch: 4, identity: 0.846

cgggctgatgtgaagcgcgatattcg	CRISPR spacer
cgtgctgatgtgaatcgcgatatcag	Protospacer
** *********** ********. *

3. spacer 10.1|3667759|26|NC_016935|CRISPRCasFinder matches to MK733260 (Yersinia phage YeP2, complete genome) position: , mismatch: 4, identity: 0.846

cgggctgatgtgaagcgcgatattcg	CRISPR spacer
cgtgctgatgtgaatcgcgatatcag	Protospacer
** *********** ********. *

4. spacer 13.1|6674036|26|NC_016935|CRISPRCasFinder matches to NC_019428 (Anabaena sp. 90 plasmid pANA01, complete sequence) position: , mismatch: 4, identity: 0.846

gcctgaaaaagaagccctcgcagcaa	CRISPR spacer
gcctcaaaaagaagcgctcgcagtag	Protospacer
**** ********** *******.*.

5. spacer 13.3|6674149|26|NC_016935|CRISPRCasFinder matches to NZ_CP047963 (Aeromonas media strain MC64 plasmid pMC64A, complete sequence) position: , mismatch: 4, identity: 0.846

tcattttcaccttgcattgggccccg	CRISPR spacer
ccattttcactttacattgggcccgg	Protospacer
.*********.**.********** *

6. spacer 1.1|395299|27|NC_016935|CRT matches to NZ_CP026382 (Sphingopyxis sp. MG plasmid pCMS1, complete sequence) position: , mismatch: 5, identity: 0.815

aaccgccggcttgatgctcaatcgtcc	CRISPR spacer
ccccggccgcttgatgctcaatcgtcg	Protospacer
  *** * ****************** 

7. spacer 1.1|395299|27|NC_016935|CRT matches to NZ_CP053441 (Rhizobium leguminosarum bv. trifolii strain CC275e plasmid pRltCC275eE, complete sequence) position: , mismatch: 5, identity: 0.815

aaccgccggcttgatgctcaatcgtcc	CRISPR spacer
gcccgccggcctgctgctcaatcgtca	Protospacer
. ********.** ************ 

8. spacer 1.3|395411|27|NC_016935|CRT matches to NZ_CP054618 (Azospirillum oryzae strain KACC 14407 plasmid unnamed4, complete sequence) position: , mismatch: 5, identity: 0.815

aaccgccggcctgacgctccacagccc	CRISPR spacer
cgccgccggcctgacgctccaccagcc	Protospacer
 .******************** . **

9. spacer 1.3|395411|27|NC_016935|CRT matches to NC_016655 (Rhodococcus phage REQ1, complete genome) position: , mismatch: 5, identity: 0.815

aaccgccggcctgacgctccacagccc	CRISPR spacer
aggtgctggcctgatgctccacagccc	Protospacer
*. .**.*******.************

10. spacer 8.1|3256452|28|NC_016935|CRISPRCasFinder matches to NZ_CP014361 (Methylomonas sp. DH-1 plasmid, complete sequence) position: , mismatch: 5, identity: 0.821

acaaaagataaaaaagaaccatcacact	CRISPR spacer
tgaaaaaataaaaaagaaccatcacccc	Protospacer
  ****.****************** *.

11. spacer 8.1|3256452|28|NC_016935|CRISPRCasFinder matches to NZ_CP023670 (Methylomonas koyamae strain LM6 plasmid pLM6, complete sequence) position: , mismatch: 5, identity: 0.821

acaaaagataaaaaagaaccatcacact	CRISPR spacer
tgaaaaaataaaaaagaaccatcacccc	Protospacer
  ****.****************** *.

12. spacer 21.1|7921143|27|NC_016935|CRISPRCasFinder matches to NZ_CP046723 (Pantoea agglomerans strain ASB05 plasmid pASB05p1, complete sequence) position: , mismatch: 5, identity: 0.815

agaacatcgctttcggctgcagcgccg	CRISPR spacer
acagtatcgctttcggctgctgcgcca	Protospacer
* *..*************** *****.

13. spacer 21.1|7921143|27|NC_016935|CRISPRCasFinder matches to NZ_CP016890 (Pantoea agglomerans strain C410P1 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.815

agaacatcgctttcggctgcagcgccg	CRISPR spacer
acagtatcgctttcggctgctgcgcca	Protospacer
* *..*************** *****.

14. spacer 21.1|7921143|27|NC_016935|CRISPRCasFinder matches to NZ_CP045721 (Pantoea eucalypti strain LMG 24197 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.815

agaacatcgctttcggctgcagcgccg	CRISPR spacer
acaggatcgctttcggctgctgcgcca	Protospacer
* *. *************** *****.

15. spacer 21.1|7921143|27|NC_016935|CRISPRCasFinder matches to NZ_CP034470 (Pantoea agglomerans strain CFSAN047153 plasmid pCFSAN047153_1, complete sequence) position: , mismatch: 5, identity: 0.815

agaacatcgctttcggctgcagcgccg	CRISPR spacer
acagtatcgctttcggctgctgcgcca	Protospacer
* *..*************** *****.

16. spacer 21.1|7921143|27|NC_016935|CRISPRCasFinder matches to NZ_CP034149 (Pantoea agglomerans strain L15 plasmid pPagL15_1, complete sequence) position: , mismatch: 5, identity: 0.815

agaacatcgctttcggctgcagcgccg	CRISPR spacer
acagtatcgctttcggctgctgcgcca	Protospacer
* *..*************** *****.

17. spacer 21.1|7921143|27|NC_016935|CRISPRCasFinder matches to NC_014258 (Pantoea vagans C9-1 plasmid pPag3, complete sequence) position: , mismatch: 5, identity: 0.815

agaacatcgctttcggctgcagcgccg	CRISPR spacer
acaggatcgctttcggctgctgcgcca	Protospacer
* *. *************** *****.

18. spacer 21.1|7921143|27|NC_016935|CRISPRCasFinder matches to NZ_CP043960 (Streptomyces tendae strain 139 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.815

agaacatcgctttcggctgcagcgccg	CRISPR spacer
tcaccatcgctttcggctacaccgccg	Protospacer
  * **************.** *****

19. spacer 21.1|7921143|27|NC_016935|CRISPRCasFinder matches to NZ_CP014127 (Pantoea vagans strain FDAARGOS_160 plasmid unnamed2, complete sequence) position: , mismatch: 5, identity: 0.815

agaacatcgctttcggctgcagcgccg	CRISPR spacer
acaggatcgctttcggctgctgcgcca	Protospacer
* *. *************** *****.

20. spacer 21.1|7921143|27|NC_016935|CRISPRCasFinder matches to NZ_CP028350 (Pantoea vagans strain PV989 plasmid pPV989-508, complete sequence) position: , mismatch: 5, identity: 0.815

agaacatcgctttcggctgcagcgccg	CRISPR spacer
acaggatcgctttcggctgctgcgcca	Protospacer
* *. *************** *****.

21. spacer 21.1|7921143|27|NC_016935|CRISPRCasFinder matches to NZ_CP034475 (Pantoea agglomerans strain CFSAN047154 plasmid pCFSAN047154_1, complete sequence) position: , mismatch: 5, identity: 0.815

agaacatcgctttcggctgcagcgccg	CRISPR spacer
acagtatcgctttcggctgctgcgcca	Protospacer
* *..*************** *****.

22. spacer 21.1|7921143|27|NC_016935|CRISPRCasFinder matches to NZ_CP038854 (Pantoea vagans strain LMG 24199 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.815

agaacatcgctttcggctgcagcgccg	CRISPR spacer
acaggatcgctttcggctgctgcgcca	Protospacer
* *. *************** *****.

23. spacer 21.1|7921143|27|NC_016935|CRISPRCasFinder matches to NZ_CP022517 (Pantoea vagans strain FBS135 plasmid pPant1, complete sequence) position: , mismatch: 5, identity: 0.815

agaacatcgctttcggctgcagcgccg	CRISPR spacer
acaggatcgctttcggctgctgcgcca	Protospacer
* *. *************** *****.

24. spacer 1.3|395411|27|NC_016935|CRT matches to NC_022242 (Achromobacter xylosoxidans subsp. denitrificans pAX22 plasmid, complete sequence) position: , mismatch: 6, identity: 0.778

aaccgccggcctgacgctccacagccc	CRISPR spacer
gctcgccggcctgacgctcgaaagcct	Protospacer
. .**************** * ****.

25. spacer 1.3|395411|27|NC_016935|CRT matches to LC155906 (Achromobacter xylosoxidans plasmid pKUN4507_1 DNA, complete sequence, strain: KUN4507) position: , mismatch: 6, identity: 0.778

aaccgccggcctgacgctccacagccc	CRISPR spacer
gctcgccggcctgacgctcgaaagcct	Protospacer
. .**************** * ****.

26. spacer 1.3|395411|27|NC_016935|CRT matches to NZ_CP026223 (Aeromonas sp. ASNIH3 plasmid pAER-3367, complete sequence) position: , mismatch: 6, identity: 0.778

aaccgccggcctgacgctccacagccc	CRISPR spacer
gctcgccggcctgacgctcgaaagcct	Protospacer
. .**************** * ****.

27. spacer 1.3|395411|27|NC_016935|CRT matches to NC_020452 (Pseudomonas aeruginosa strain COL-1 plasmid pNOR-2000, complete sequence) position: , mismatch: 6, identity: 0.778

aaccgccggcctgacgctccacagccc	CRISPR spacer
gctcgccggcctgacgctcgaaagcct	Protospacer
. .**************** * ****.

28. spacer 1.3|395411|27|NC_016935|CRT matches to NZ_MF168945 (Pseudomonas aeruginosa strain FFUP_PS_35 plasmid pJB35, complete sequence) position: , mismatch: 6, identity: 0.778

aaccgccggcctgacgctccacagccc	CRISPR spacer
gctcgccggcctgacgctcgaaagcct	Protospacer
. .**************** * ****.

29. spacer 1.3|395411|27|NC_016935|CRT matches to NZ_MF141039 (Pseudomonas aeruginosa strain PAcoop101 plasmid pCOOP-101, complete sequence) position: , mismatch: 6, identity: 0.778

aaccgccggcctgacgctccacagccc	CRISPR spacer
gctcgccggcctgacgctcgaaagcct	Protospacer
. .**************** * ****.

30. spacer 1.3|395411|27|NC_016935|CRT matches to NZ_MF564290 (Pseudomonas putida strain KSS435 plasmid pVIM_Pse-KSS435, complete sequence) position: , mismatch: 6, identity: 0.778

aaccgccggcctgacgctccacagccc	CRISPR spacer
gctcgccggcctgacgctcgaaagcct	Protospacer
. .**************** * ****.

31. spacer 8.1|3256452|28|NC_016935|CRISPRCasFinder matches to NZ_KP342511 (Enterococcus faecium isolate N12-493 plasmid pEfm12493, complete sequence) position: , mismatch: 6, identity: 0.786

acaaaagataaaaaagaaccatcacact	CRISPR spacer
tcaaaagacaataaagaaccatcatcat	Protospacer
 *******.** ************.  *

32. spacer 14.1|6828694|27|NC_016935|CRISPRCasFinder matches to NZ_CP031696 (Erwinia billingiae strain TH88 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.778

ccggttatttcccgttatttcccggag	CRISPR spacer
tacattattgcccgctatttcccggag	Protospacer
.  .***** ****.************

33. spacer 16.1|6978457|27|NC_016935|CRISPRCasFinder matches to NZ_CP032306 (Salmonella enterica subsp. enterica serovar Braenderup strain FORC93 plasmid unnamed2, complete sequence) position: , mismatch: 6, identity: 0.778

tcgactatttcccatcatttcccgaag	CRISPR spacer
tattgtatttcccatgatttcccgaat	Protospacer
*    ********** ********** 

34. spacer 21.1|7921143|27|NC_016935|CRISPRCasFinder matches to NZ_CP013110 (Sinorhizobium americanum strain CFNEI 73 plasmid C, complete sequence) position: , mismatch: 6, identity: 0.778

agaacatcgctttcggctgcagcgccg	CRISPR spacer
cgaagatcgctttcggcttcagcgttc	Protospacer
 *** ************* *****.. 

35. spacer 9.12|3289281|30|NC_016935|PILER-CR matches to JQ768459 (Pseudomonas phage Lu11, complete genome) position: , mismatch: 7, identity: 0.767

gagcggcaaatgcagcgaataaaccggttt	CRISPR spacer
tggcagaaaatgcagcgaataaaccgcgta	Protospacer
 .**.* *******************  * 

36. spacer 9.12|3289281|30|NC_016935|PILER-CR matches to MN694663 (Marine virus AFVG_250M439, complete genome) position: , mismatch: 7, identity: 0.767

gagcggcaaatgcagcgaataaaccggttt-	CRISPR spacer
tagcggcaaatgcagctaat-aattggtcaa	Protospacer
 *************** *** **..***.  

37. spacer 21.1|7921143|27|NC_016935|CRISPRCasFinder matches to NZ_CP015738 (Shinella sp. HZN7 plasmid pShin-02, complete sequence) position: , mismatch: 7, identity: 0.741

agaacatcgctttcggctgcagcgccg	CRISPR spacer
gcgttttcgctttcggccgcagcgccg	Protospacer
. . . ***********.*********

38. spacer 21.1|7921143|27|NC_016935|CRISPRCasFinder matches to NZ_CP016452 (Sinorhizobium sp. RAC02 plasmid pBSY16_1, complete sequence) position: , mismatch: 7, identity: 0.741

agaacatcgctttcggctgcagcgccg	CRISPR spacer
gcgttttcgctttcggccgcagcgccg	Protospacer
. . . ***********.*********

39. spacer 9.8|3289279|32|NC_016935|CRT matches to JQ768459 (Pseudomonas phage Lu11, complete genome) position: , mismatch: 8, identity: 0.75

gggagcggcaaatgcagcgaataaaccggttt	CRISPR spacer
gctggcagaaaatgcagcgaataaaccgcgta	Protospacer
*  .**.* *******************  * 

40. spacer 9.12|3289281|30|NC_016935|PILER-CR matches to NZ_CP049158 (Caballeronia sp. SBC1 plasmid pSBC1_2, complete sequence) position: , mismatch: 8, identity: 0.733

gagcggcaaatgcagcgaataaaccggttt	CRISPR spacer
catccacaaatgcagcgaatacaccggcgc	Protospacer
 * * .*************** *****. .

41. spacer 9.12|3289281|30|NC_016935|PILER-CR matches to NZ_CP049318 (Caballeronia sp. SBC2 plasmid pSBC2-2, complete sequence) position: , mismatch: 8, identity: 0.733

gagcggcaaatgcagcgaataaaccggttt	CRISPR spacer
catccacaaatgcagcgaatacaccggcgc	Protospacer
 * * .*************** *****. .

42. spacer 9.2|3288940|32|NC_016935|CRT matches to CP007645 (Rhizobium etli bv. phaseoli str. IE4803 plasmid pRetIE4803d, complete sequence) position: , mismatch: 9, identity: 0.719

cggagcggcaaatgcagcgaatcagccggttt	CRISPR spacer
ttttcacgcaattccagcgaatcagccggttt	Protospacer
.      **** * ******************

43. spacer 2.2|1008406|34|NC_016935|CRT matches to KT591491 (Mycobacterium phage Bricole, complete genome) position: , mismatch: 10, identity: 0.706

taggtagtgagcagccgttcttcggtggccccgg	CRISPR spacer
tggcggctgagctgccgttcttcgttggcccttc	Protospacer
*.*  . ***** *********** ******.  

44. spacer 2.2|1008406|34|NC_016935|CRT matches to NC_021299 (Mycobacterium phage PegLeg, complete genome) position: , mismatch: 10, identity: 0.706

taggtagtgagcagccgttcttcggtggccccgg	CRISPR spacer
tggcggctgagctgccgttcttcgttggcccttc	Protospacer
*.*  . ***** *********** ******.  

45. spacer 2.2|1008406|34|NC_016935|CRT matches to MN586024 (Mycobacterium phage TyDawg, complete genome) position: , mismatch: 10, identity: 0.706

taggtagtgagcagccgttcttcggtggccccgg	CRISPR spacer
tggcggctgagctgccgttcttcgttggcccttc	Protospacer
*.*  . ***** *********** ******.  

46. spacer 2.2|1008406|34|NC_016935|CRT matches to MK937612 (Mycobacterium phage LilhomieP, complete genome) position: , mismatch: 10, identity: 0.706

taggtagtgagcagccgttcttcggtggccccgg	CRISPR spacer
tggcggctgagctgccgttcttcgttggcccttc	Protospacer
*.*  . ***** *********** ******.  

47. spacer 2.2|1008406|34|NC_016935|CRT matches to MH697587 (Mycobacterium phage IPhane7, complete genome) position: , mismatch: 10, identity: 0.706

taggtagtgagcagccgttcttcggtggccccgg	CRISPR spacer
tggcggctgagctgccgttcttcgttggcccttc	Protospacer
*.*  . ***** *********** ******.  

48. spacer 2.2|1008406|34|NC_016935|CRT matches to NC_041970 (Mycobacterium phage Bongo, complete genome) position: , mismatch: 10, identity: 0.706

taggtagtgagcagccgttcttcggtggccccgg	CRISPR spacer
tggcggctgagctgccgttcttcgttggcccttc	Protospacer
*.*  . ***** *********** ******.  

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	1641032 : 1714652	80	Bacillus_phage(25.0%)	tail,head,terminase,capsid,protease,portal,integrase,transposase	attL 1644133:1644154|attR 1706516:1706537
DBSCAN-SWA_2	3407286 : 3417726	10	Staphylococcus_phage(50.0%)	NA	NA
DBSCAN-SWA_3	6455366 : 6492424	54	Listeria_phage(24.14%)	tail,terminase,capsid,integrase,plate	attL 6459149:6459164|attR 6493874:6493889
DBSCAN-SWA_4	8085654 : 8095019	7	Mollivirus(33.33%)	NA	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>NC_016935|1641032:1714652|DBSCAN-SWA
AATGAATATCGAGGAGATCCGTCGACAGTTCCCGATTCTTCATCAGGAAGTGAACGGCCATCCGCTCGTATATTTGGATTCGGCGGCTACCTCGCAGAAGCCCACAGCAGTTATCGAAGCCGTCAAGAACTATTACGAGTGGGATAATGCGAACGTGCACCGCGGCGTGCATACGCTGGGCTCCCGGGCGACCGACGCTTATGAAGGGGCGAGGGAGAAGCTCCGCCGTTTCATTAATGCCCGGTCTACCGAAGAAATTATTTTTACGCGGGGAACGACAACGGCCATTAACCTGGTCGCCTCGTCCTATGCCAGGGCGGTGTGCAAGGAGGGTGATGAGATTGTCATCACCCCCATGGAGCACCACAGCAACCTGATCCCTTGGCAGCAGGTGGCGCAGGCGACCGGTGCGGTCCTCAAATATATTCCGCTGCAGCAGGACGGATCGATCTCGCTCGAAGACGTGGAAAAGACGATTACGGAGAAGACGAAGATGGTCTCCGTCATGTACGTCTCCAACGTGCTCGGCGTTGTCAATCCGGTGAAGGAGATTGCGGCCATCGCTCACCGTCACGGCGCCAAAATGCTGGTCGACGGGGCGCAGAGCACACCGCATCTCAAGGTTGACGTGCAGGATCTGGACTGCGACTTCTACGCCCTCTCCGGGCACAAGATGTGCGCACCTACCGGCATCGGGGCACTCTATGGTAAGAAAGAGCTGCTCCAAGAGATGGAGCCGATCGAATTCGGCGGAGAGATGATCGACCATGTGGGCCTGTACAACTCCACGTGGAAGGACCTCCCGTGGAAGTTCGAGGGCGGCACGCCGATTATCGCAGGTGCCGTCGGTCTCGCGGCCGCGATCGATTTCCTGGAGAGCATCGGCATGGAGAACATCGACCGGCATGAGAAGCAGCTGACCTCCTACGCGCTCGAGCGCATGGTGGAGATCGAAGGACTGACGATCTACGGCCCGGGCCAGGATCGTGCAGGACTCGTCACATTCAATCTCGACGATGTGCATCCGCACGACGTCGCTACCGTGCTCGATGCCGAAGGCGTAGCCGTCCGTGCCGGCCACCACTGCTGCCAGCCGCTGATGCGCTGGCTTAATGTCACCGCAACGGCTAGAGCCAGCTTTTATCTGTACAATACCGAAGCCGATGTAGACCGACTGATCACCGCTCTTATCAAAACAAAGGAGTACTTCGGCCATGTCTCAACTTGATGATTTGTACCGCCGCGTCATTATGGATCATTATAAAAATCCCCGGAACCGGGGAACCTTCGATGAAGGCGAAGCCGTCAGCATCAACCTGAACAACCCGACCTGTGGCGACAAAATCCAGCTGCAGATGCAGGTGGAGGACGGCCGGGTTAAGGCGGCGAAGTTCGTCGGAGAAGGCTGTTCGATCTCGCTGTCGTCCGCTTCCATGATGACCGATGCCGTCAAAGGCAAGACGCTGGAGGAAGCGCTGGAGATGGCCGAGAACTTCTCGGGTCTCATGAAGGGCGAGAGCGTCGAGTTTGAGTATGAGGATATCGAATCCCTGTCGGGCGTCAATAAATTCCCTGCGCGGATCAAGTGCGCAACCTTGGCCTGGAATGCTCTTCGCAAGGGCATCGAACAGTCCAAAACCCAGTAATTAAGGAGGCGAGGAATCATGGCAAAGAAGATGCCGGAAATGGAAGATTACAAGTACGGTTTCCGCGACGAGCACAAAGCCATTTTCCAAAGTGGTAAAGGCTTGACCAAAGAAATCGTAACCGAAATCTCCCGCATGAAAGGCGAGCCCGAGTGGATGCTCGAGTTCCGACTGAAGTCGCTGGAGCAGTTCTTCAAGATGGAAATGCCGACTTGGGGCGGCAATATGGATGACCTTGACTTCAACGACATCCAGTACTATGTCAAGCCATCCGAGAAGCAGGGCAAAACGTGGGAGGAAGTTCCTACCGAGATCAAGGAAACCTTCGACAAGCTGGGGATCCCTGAAGCGGAACAGAAGTTCCTTGCGGGCGTATCCGCCCAGTACGAGTCCGAGGTCGTATACCACAGCATGCAGAAGGACCTGGAAGACCAGGGCGTTCTCTTCATGGATACGGACACGGCGCTGCGTGAGTATCCTGAGATTTTCCGCAAGTACTTCGGTACGGTCATCCCGCCAAGCGACAACAAGTTCGCTGCACTGAACAGCGCGGTATGGTCCGGCGGCTCCTTCATCTATGTTCCGAAGGGCGTCAAAGTGGAAATCCCGCTGCAGGCTTACTTCCGGATCAACTCCGAGAACATGGGCCAGTTCGAGCGTACGCTGATCGTAGCCGACGAAGGCAGCTTCGTACACTACGTGGAAGGCTGTACCGCTCCGGTATACAGCACGAACTCCCTGCACAGTGCCGTGGTTGAGATTTTGTGCCTTAAGGACTCCCGTGTACGTTACACGACGATCCAGAACTGGGCGCCGAACATCTATAACCTGGTTACGAAGCGTGCGGTTGCAGAAGAGAACGCCACGATGGAGTGGGTTGACGGCAACATCGGCTCCAAGCTGACGATGAAGTATCCTGCCGTAGTTCTCAAAGGCCGCGGCGCGAAGGGTATGGTTCTCTCCATCGCGGTAGCAGGCAAAGGCCAGCACCAGGATGCCGGTGCGAAGATGACGCACCTGGCGCCGGACACGACATCGACGATCGTATCGAAGTCGATCTCCAAGCATGGCGGTAAGGTAACGTACCGCGGTCTGGCTTCCTTCGGACGCAACTCGCAGGGCTCCAAGGCGAACATTAAGTGCGATACGCTCATCATGGATAACGAGTCGACATCCGATACGATTCCATACAACGAGATCATGAACGACAACATCACGCTGGAGCACGAAGCAACGGTTTCCAAGGTATCCGAGGATCAGCTCTTCTACCTGATGAGCCGCGGTCTGTCCGAAGCCGAAGCGACCCAGATGATCGTTATGGGCTTCATCGAGCCGTTCACGAAAGAACTGCCGATGGAGTACGCGGTCGAGATGAACCGTCTGATCAAGTTCGAGATGGAAGGATCTATCGGTTAAGCCTTATAGATCAAGGGGTTTTGGGAGAGCGCAGAGGGGTTTGCCCCCTTTTTGCCCCCCAACTTATTTTTGGATATATTTTTCGTAGAGGGCGAGTGCATCGTCCTCTATTTTTTTTGTGACATGTAGATACGTGTCTGCGGTTATTTTTACGCTTGCGTGTCCAAGTCGTTCGGACACGTATTTTATATTTGCACCAGCTTCTAGTAGGTGGACGGCGTGAGAATGGCGAAGTGCGTGGGGGGAAAGAACGGGTAAGTTTGCTCTTTTACATACGGCTTTAAAATAATCACGAACGACATTAGTACGAAGCCATCTTCCATCATGCTGATGAAATACAATATTGTCTTTTGCAGGCTTATAATTTACATACTGCAAAATGACTTCCTTTTGGTTTACTTTGTGACGTTTTAACACCTTCAAAGTGTATTCGTCTAGCTTGATCTCCCGGTTACTCATTTTAGACTTTGGCGTAGAGAGATAGGGGGCAGAGTTAAGAGGGTAGACAAGAGTTTTATTAACGGTAATAGTAGAGCTATCCATATTTATATCATCCCAAGTGAGGGCTAGAGCTTCACCAATTCTAATGCCAGTACGGGATAACAACGTAAAAAGTGCGAAATACTGAATGGATGCTTGATATTTCGCATGCTTCACAGGCTCTTTTACTGCGTCCAAAAACGTATCTAACTGCTCTCGTGTAAAGTACTGCACTTTCTCAGTCGTTTCAACGTCTCTAGGGATTTTTATTTTTTGAACTGGGTTCTCCCGTATTATGTTGAACTCATGAACAGCATCCGTCATGGCGCTAGAAAAAATGCTGTGAATTCTCCGCACTGTCCCTTCGCTGTAACGTTCCTTGAGTTCATTGATCCACTTTTGGTACTCATTCCTGGTTATGTCCTTTAGTCTGTATTTTCCCCATCGAGGTAAAATATTTAATCTCACGTTGCGTTCCTGAACGCTATATGTGACGGGTTTTACAGTAGGCTTTTTGTAAGTTTCTAACCATTCTTCGAAAAACTTGTCTATCTTCTCAGATCCGTTTTCACTAAATCCAAAATGATTGATCTTGCTTGCTTCCTCCATTGCTGCATGCTGCGCTTCCTTCTTTGTTCTGAATCCCCCTTTTGTTTTTTCCTTCTGTTTACCTGTTTGTCTCTCGACATATTTAATTCGGTACTCCCACGTATCTCCCCGTTTTCGATAATACGCCATTTGTATACCCTCCCCAAATCGAATAGTAAACTCTACGGGCAATTTGATGATATCTAGTATAAGCCATCTCGGCTGATACTCTAAAAGTATTTGTTATTAGCTCAATTGCTGCGTGTTGATCCTGAGGCAGGCTAATACGACGTAGCATTAGAAATGGAATGCTTGCGTACAGAACAAAATTTTCAGCGTCCCATTCTTGCCACTTACGCATAAGTGGGTGGAGCTTCAATTGGTTTCCTGCATGACGTTTAACGTGACAAAGTTCATGGAGAAACTGTTTCCACTGTTCCTCTTCAGATGCCTGATCATTTATATGTACAGTTAGAACTCCATTTCGCATAGAAGAAAAACTTATGCTTGAATAAGCAATTTTTATATTTAGTGCTGCGGCGATGTCCTTGATTGTCAATTGTTCAGGGCGGAAAATGTTAATACGGGAATACAGGTTATCAACGAAATCTTCCAAGTGCGTGGTTTGGTATTTCTTCAGATCCATTAGACACCTCGACAGAAAATCGAATATATGTTCTGTTTTTGGCTAAAAAGAAAAGCCCATAGGGCTTATTTTGTTTTAAGCAGATAGTTCCTCAATAACGTCATTGCGATTTGACCATAGTACTGGTTTAATATCGTACTCCTTGAAAGCTAAAATGATATCAGACTTTACTGTTTTCGTACTATCATTCAGAAATGTATACATTAAGGTGCCTTCTTTTCGAGTGTCCTTAGAGTCACCCCATGCAAACAACAAGCTTTTTGCCTTGTCAATTGTTGGACTATTAACTGTTGAGATTAGTCTTTCAGGCCGAGATTTGGAACGTGGTATGAGAAAATCAAATTTGTGGGTTAATCCACTTTTGCCGGTTAAGTTGATCTGTTCACTGAATCTTATATTATTCTCAAGAAAAAAATTCTCCACATCCTCAAAAAACATGTTATGGACATTTGTTTGAGAGGTCATAAACATATCATTAACTGCCAACATCGCTTGCAAAAACAAATGTTTTTTTTGTGGGAAGTTATTTATGGAGGCTTCAGAGATTAATTCGTTATCTTCCGATAATTTTACACCATAACCCGCTAAAATTGTGTTAAGCAAATCCTTACGGCGCTTACTCTTAAAGTCGCATCCCGCTGACATTAAATCATTCAAAATATATCCATCATCTGTTAAGTGTAATTTATTATTGTCGTTTGTAATGACGTAAAATTGCAAAAAGTCATTATGTCTGTCCATGAGGGGGGAGGTTATTTCAAGCGCACCATCTATTTCAGTTATTTTTGTCTGTTCATTTAACCAATTCATGTATGATTTTTTTAACTCATCTATAAGACCTTTCATGACTCTCCCCCCCTTTATCTTTGGTTTAGAATAGTGTTCTTGAAAAAGCCGTGGGTATATTTTCAATATTATTATACTCAAGAAAATCGATTAAGACACTTAGTAAATCACTTGTATCTGTTTTAATTTCATTTTCTAATGGAAATGCCCACTTATCATCAAAACCCTCTCTATAGATATGAATATGTGGACAAGGAATCACATTGCCATCTGGGTTCATATGGGCTGGCCCATCAATGTCGAGGCGTAATAATATCGTTGATTTATTATACAACGTTAAGTAAGTACATTTTGTCGGCTTTAACTTCCCTTTTCTGTTTATGTTGATAACAAAATTCTCATCTTTGTAGATTTTAGATTCAACGTCTAGGCGCTGTTCTTGTCCTAGAGGGGGCAGAACTATGTTATTACTATTACGTCCTTTAATTATCTTGAGCATATTTAATAGATGTTCAGCTTCTGATTGCGTAATCAAGATCTCACGTCCAATTGTAGGATTAATGTAGTTATTTAAATTAATTTCGAATTAAATATTTGCTCCTATAATCTCAAAACTGCTATCTGCTAGTAATATTCTGATTTTATTTCTTCTTACTTTTCTTTTCTCTTTCCTCGGCTTCTTGCATTAGTAGTTGAGCACGCACATATGCCTTGACTTCTTCTTGCCTCTCAGGTGTGAGTTTCTCCCAGCCATAGAAGAATAAGTCCATATCTGGATCATCCAAAGGATCCTTAACTTCGGGTAAGGGAGCAGGGTCGTTAGTACGTCCAAGTAAATAATCTGTAGAGGTTTCTAATATGTCTGCAATTCGCTTTAGTGCTTCAGGATCTGGCTTCCTGTCATTTGTTTCATACCTGGATAGCTGCACGATCGTAAGTTTGGTTTTGGCAGCAAACTCTTTTTGAGTCCACGCCCGTTTCTCACGAAGGTATTTTATTCGGTTGCCCAGATCCAGCATAGCGATTCCTCACTTCTGTAGTTGTATATAGATAATACTACCATTACCGAAATGGTAAAAGAATAATATTACCAAAAAGGTATTGACGTTGCCGAATTGGCAATGTAATATTTGGATATAGGTTATTACCGATACGGTAATGTGGAGGTGGTGAAAATGCGTAAGGTAAACCTTAGAAAGATAAAACAACTCCGTAAAGAGGCAAAATTCTCTCTTGATGAAATGGCTCAGTTACTTGGTTATGAGAGTCCTAATGGTTACTATTATCTAGAGATTGGTCGTGGGAAATTCTCCGCTGAGGCTTTAGCCAAGGTAGCAGATAAATTTGGGGTGCCTATAGACGAACTTTTTTTTATTCAGGATGTTACCGAAATGGCAAATTAATTCTCAAGGAGATAAAAGGCATGGCGATATTGGAAGGAGGCGAGCTACATGCTCAAAGTACAAATCGATGAAACAGAGTTTCAGCGCTTGTGTAGAGATCGTATCGCAGATCTTGTGAAGGAGGTCGAAGCAGAACTCGTATTCTGGGATTCAGCAGAATTAAAAAAGCGAACTTGCATGAGTTGGAACACTATTCAGGAATTATTCTTTTTTGATCCAAGATTCCCCAAAAGAAAGATCGGCAGCAAGTGGTATTTCCCAGCTCGCGAGACCAGAAGATTTTTGGAACAGTGGCTTATTGAACAGCCGATGTTGTGACGTATTGGATGAGGAAAGCCCGTCTCCTAGGGCGACGGGCGTTGTGGGGGAGGTGAGGGGGATGTGATCTGATAAACCAATGATAACCTCTACTCAGTAATGGCACCAATCCACTTTGGAATAAATTCCAACCTGGACTGAAAGGAGGTGAGAGACGTGATTATTACCTCGAAAGAAGTAAGCGCTGAGTTGCGGAAGAAACGCAGAGCCGCTGGGTATTCGCAGGAAGACATGGCAGGATATCTAGGCGTTACCCAGGCGACGATCAGCAAATATGAGCGAGGCCGCATACCTGATGCTGCTACATACAAAATGTGGCTTTGGTTCTGCGAGAACCCACCGATAGCAAGGTTCGAAATCAATCTGGACGGGAGGAATAATCAACATGCGTAAGCAGATGACGGATAGTGAATGGCGGGGCCAGTTGCTGGCCTGGAAGAAGAGCCGGACGGTGATTGAAGGCATGGACATTATCGATAAGCTTATCGCCGAGTCCGAGCGCGAAATGGAACTTGCAGCTGCTAAAAAGGAAAAGACTCGCCGGTCAGGGCGAGCCTCGTTGAGAACCCGGTTAAAGTTTCTCATGCTGTTATTTTACCACAGAACGAACGTTCGTGGGAAGGGGGCGTCCCCGGATGCCTGATTCCATCACATATGACTTCTATGAATGCCAAGAATGCTGCCTTGGTTACGCAGTTGAATCAGAGCAACTCGAGGAACCGGCTTGCCCCAGTTGCTCAGAAACCAATGCTCGATACGTGATCTCCCGTGAGATAAAAATGAGCGAAGGAGCAGCAGTGAAATGAAGAAAGCGACAGGTATGACAAGAAACCTTGATAGTTTGGGTAGGATTGTGATCCCAAAGGAACTTCGAATGAACATGGATCTCGATTTACATGATCCATTGGAGATATTCGTAAATGGTGATGAAATCATTCTCCGAAAATACACTCCTGGCTGCTCACTTTGCGGCCAGGTAGATAGTCCCATCACCTCAGTGTACCCAGGTAAGAAGATCTGCACCACCTGCATTAAGATCATCGCGGAAAAAGCGGCAAAGCTCAACCGAACAGCAACTTGACCATATCTGGTGAGGGTCCGGTACGCCGGTCCTTCAGAGATGCGGCCAAGCCTCATCGAAAAAACATTGTCGGGAGTGATTAGTGAATGGCAAAGGGTAAGATGCAAGTTCGTTTTACTGCGGAAGAAAAGCAGATGGTGGAGAAGCTCAACGAGGAAAAGGTTCCGGCGGCGAAGATTGCAGAGCAGCTGAATGAAAAATTCCACAACAACAATCCGATTCGTAAAGCCCAGTCCGTATACTACATGCTCAAAGCCATGAAGAAGTCCTCAGGGACTGCGAACTAAGGAAAAAAAGGAAAGAACCCGCCTGCCAGCGGGCCCTGAAAAAAACGAATCTGCCGCCAGTGTACCATGCTGGCGGACTTTACATCAAGGGGGGAAGACGGTGCCATTAAGAGCATCCAAATCGGACCTTTTGAATCGCCTCGAAACCACGCTCGATGAGAATGAAGAGTACATTGGGAGTACGGTTTGGAAAGCGTTAGAGGAAGCATTTGAACGTGTTGATGACGAGGCCGATGAGATCGAGAGAGAACTTGAAGAAGCTCAACAGCGAATCGAGGAGCTTGAATCGGCACTGGAGGCGCTGAAATATGCAAGCTCTTAAACTGGTCAGTGTCAAAGACATGCCCAGGGAAGATTGGCTGGAGTACCGTAGGAAAGGCATTGGGGGCAGTGACGTGGCTCCGATCTGCGAGCTCTCGAAGTACAAATCGCCCATGGCTGTCTACTTGGATAAGATCGGCGAGCTGCCTCCGCTGGAGGATAACGACAAAATGAAAGCCGGTCGGATGCTCGAGCCGCTGATCGCCAAATGGTTCACCGAGGAGACCGGGATCCGCGTCATGCAACAGCATTCGATCTTCAAACACAGGGAGCACGACTTCATGCTGGCGAACATTGACCGCTGGGTGATTGGTAAGAACGAGGGCCTCGAGATCAAGAACACCTCTGAATACAACCGTGACGAATGGGCAGGCGACAAGGTACCGGTGGAGTACATGCTGCAGTGCAATCATTACATGGCTGTCACCGGTGCTGAACGCTGGTACGTTGCCGTTCTGATCGGCGGTTGGGACTTCCAGTGGCGCATTATCGAAAGGGATGAGGAGTTAATCCGGAACCTTATCGAAATCGAGTATAACTTCTGGCATAACCACGTATTAGCCAAGCAGCCGCCGGCATATGGACACCAGGATACAGGGCTCTTAAAGGATCGCTTTCCGGAATCTCGACCCGGGGCGAATATGGAGCTTGGCGAGGAACATTCGGAGCTCATTCGGCTGGTCTTTGACAGCAAGAAAGCACTTAAACGAGCCGAGGAAACACACGAGACAGCGAAGAACCGCATGAAGGCCGTTATGGGCGAGCATGAGACAGCTTGGTTCCAGGGCGAGCCGGTGTTCACGTGGAAGTCCAACAAGAAAGGTGTTCGAAGTTTCAAAATTGTTGGAGGTGATGAGTAACCATGGCAGCACCTGCTAAAGCAACAGATCAAAAGGAACTCGGTAAGGCGCTGGCGAACAAGGCCGCAGCTAGTAACGGTCAAGGTAAAACCATAGCCCAGCTATTCGATGAAATGAAGCCTGCTATCGCTCAAGCGATTCCCAAACACCTCACACCTGAGCGATTACTGCGTATCGCAACAACCTCGATCCGAACCAACCCCAAGCTGAAAGTCTGCACTCCTGAGTCCCTTCTTGGCGCCGTAATGCAATGCGCCCAGCTTGGTCTGGAGCCCTCCATTTTAGGTCATGCATACCTGGTACCCTACCGTAACAAGAAGAAGGATGCGGCCGGCAAGGACTTGGGCTGGGTCGACGAGGCGCAGTTCCAGATCGGCTATAAAGGATATATCGAGCTCGCACGACGGACGGGGCATGTCTCCAGCATCGTGGCGCAGGCTGTACATGAAAAAGACCTGTTTGAATATGAGTACGGCATCGATGAGAAGCTCCGTCATGTGCCGGCCGATGGAGACCGTGGCCCTGTGACCAAGTATTATGCTTACGCCAAATTCAAGGATGGCGGCTATTCCTTCATGGTAATGAGCAAGCGAGACATCGAGCTGCATCGCGATAAATTCTCCAAAGCGAAGACTTACGGCCCCTGGGTGGATCATTTTGATGAGATGGCAAAGAAGACGGTGCTCAAAGCTTTGATGAAGTACATGCCGATCTCAGTCGAGTTCCAGAAGGCCGTTTCGATGGATGAGACGACCAAACGAGAGGTCTCCGACGACATGTCCGAGGTGATCGATGTCACCGATTGGAGCGAGGCTCAGGTAGAAGAGGCAGGTGAAGAGCGTGACCCTGACACAGGCTTTCCTACCAACAGTCCACCCGAAGATGAGGTTACGTTTGAATGATGGAAATGCACCATACTCCGCTGACGAAATCGATGATCAGCCAAGACCTATGGACTCTGGTGGAATCGGAGCCGGATCGGTTTAAGCAAGAGGTTAAATCATACTTCGCCCGTACATATCCTGGCTTCGTTGTCGTTCGGGCAAAGTACCCTCTGATCTATTTGCGAGATCAGCGCGTGAATAACGTTTAGGAGGTGCGCCGGATGGCGAATCCACAGACAGAAAACGGATATATCCGCATAGCAAACGAGATCTGGGACGAAGTCATCCGGCGTGACTTCTCCAAACGGCAGAAAGACATCATGCACTTTATATGGCGGCTCTCATACGGCTGCCGCAAGAAAGCAGCATTCATCCCTAAACTGGTCCATTTTGAGCTTTGTGGCGTTGGTAAGAATCATATCAAAGATGAGCTCCTTTATCTCGAGTCATGCAAGGTGCTGTTTTGGGACCGGGAAGCCAAATTATTCGAAGTAAACAAGAACTACGACGAGTGGCAAGTCTCACCAGTTAAAGGGTGGGATGAGTTCCGATTCGAGGAATTAATCGCTCTGAACCTGAAAGAAAGTTCCCAAAATGGGAACGTAAAAGTTCCTGAAACAGGAACAAAAAAGTTCCCGAAACAGGAACTTTCCGAAGATGGCGAAAACGAAAAGTTCCCAAAAGAGGAACTACCGAGTTCCCAAAACAGGAACTTTTCCGGCGAAAAAGTTCCCAAAACAGGAACTGCGACACCCGATGAGCCCAGTCCTGGCGCGGGATCTCAGCCCCGTAAAGACATTATTAAAGACAATAATAAAGACAGTAGTAGTACTACTAAGGTAATACAAATGAACCAAGTTACAGGACATGGCCGCCACCAGGACTTTTCTTTCGGCCGAATCTACTCCATTTACGAAAAGCACTTTGCAGTGAATGGTACGGTCAGCGAGTTTGAAGTCCAGGACCTTGGATTCTTGTTTGATGACTATGGGGGAGAGTGGGTATACGAGGCAATGCGAGAGGCGGCGAGGTACAAGGTCTTCACGCTTGCTTATCTTACCAAGGTCTTAAAGGGATTCAGAGCCCGCGGCAGTACGCAAAAAGAGGAGCCGTTGCAGGTTGTCGGAGGACAGCCGATTTACCAAGTAGCCGAAGATGATCCCATAACTCAGCAATTACGTGAGGTGTATCAGGCGTATGCTGCAAACGGAAGCTCTTGAAATGGTCATCCTTGGATCGGTCTTTGAGGATCCAAGTCTCGCCCGGGAAGTTATGGCCACGGTGACGATAGACATGTTCCGGCAGCCCTGGAACCGCAACTTGTACCGGATGATGGCCTGGCTGGAGAAGAACAACCACCCGGTGAATTACACGAACATTTCAACCTACTTCGCTAAGGACATGGGCAAGATCGGCGGGGTTGACTATCTGCTCAAGGTCATCGGGTCGGTCGTTTCCGTCAGCGAGATACGTGAAAACATGAAGCTGCTGGCCGAGCTCGATGCCCGCCGGAAGCTCTCTCAGCTGATTGAGCAAACCAGGGCACTCATCGACGACCCGGCCGCCGGCAGGTTCGACGAAATTCTGGATACCTTTGAGCAGAAGGCGCTTGAAATTCGGCCCAAGGTGAGCCAGGAAAACAAATCGGGGGACCGGATCCGGATGTGGTTTGAGAACCTGTTGCTCCGGAAGCAAAACCCGAGCCTGGCGTTCGGAGTTCTAACCGGCTGGGATCCGCTTGACCGTATGACCCTCGGATTTCAGCGGAGCAACCTGATTGTGATCGGAGCGAGAACGAGCATGGGAAAATCTGCTTTCGCAAACGAGATCAAGGTTCGGGCATCCTCCATGGGAAACAAGGTGGCAGATTTCAGTCTTGAAATGACGATCGAGCAAATCTATAACCGCATGGCCTCAACGATGTGCGGAATCCCCCTACAGGCTATACGGATCGGAAATCTGACAGACTTCCAGATTGGTCTGATTGCAGACAAGCTGGACGAGTTTGCTAAGATTCCAATCGACGACTCCAGAGGGGTGACAACGGAATACATCACCTCGGAGATGCGTCGGATGAAGCGGCAAGAAGGGCTTGACCTTGTGGTTGTCGATTACCTGCAGGAGATCAACGAGACAGCCGAGCAGAACGATAACGGTGGCTCTGCACTTCATAGGGTATGCCAGAAGCTAAGGGCGGCGGCCAAAGACTGCGACTGTGCAGTAATCGGACTCTCCCAGGTGAAACAGGATGTGGACAGCAGGGCAAACAAGCGGCCGATGGTTTCAGATCTATCTGGGAGCGCGGCGATCGCGGCTGTAGCAGATGACATTCTACTTTTGTACCGGGATGAGTATTACAACCCGGAAACCTCGGACAAAGGCATTCTCGAGGTAAACGTGGCGAAACAGCGGAACGGCCCAACGGGCATCGTGAAGTTGAAATATGATAAGGACACTCAAAAAATCACAGTGTGAGGTGAGCGGCCATGAATCGCTGGCACGTTTACGAGTGGCTTAAACAGACATACATGGCAACTGGAACGGTTCCCACGATGGGACAGGCTCAGCAGCGATTTTCAAGCCATGTAGATCCCGAGGAGCTGACGGAAGGAATCGACGAATTCCTCACGGCCATCCGGGAGTACCGAACAGAGGAGGCAGGTTCATGCGAAATGTAGATGATCCTCTTTTCCAGACAATCCACCGGTTTGTGATTTACAACGGCAAGGACCAGCTGGGTGGAGTGTACGTTTTATCGGAACGATTCATCTTTGCTCCGAAGAAAGCACGCCACGGCTTGCGCTGCGTGAAGGTGGTGGGATACTGATGGATCCAATAGCCAGAGCAATCATTAAACGTGTAATCGATGATCTGGAGACGAAGGCAAGGGAGCTGCAGGTGCCTAACATTCCGGGAGCAGGGTCAGAGTACGTGGATGGGTTCAAGACAGGTAAGGCTGTTGGCTTATTCCAAGCGAGCATGGAGCTTGAGAAGGTGCTGGAGGATGCCTAGGTACGTTGGGATAGATCCCAGCACCAAAACCGGGTTTATTGTTCTGGATGAGGATGGCGAGGTCTGGGAAGCACGAGAGCTCGAGGGGATGGGCGAGAATCCGGAAAGGATGCATGATCTGATCTGCCAGGTAGGCCAGCTGATACAGCCAGAGGACCGGGTTGCGATTGAGGGTTTCGGATTTGCCAGCCAACGTGGTTTCGAGCTGGGCGGCATCGGCTGGGCAATCCGGCTGAACCTCTTCGCAAGACAGATCGGATACACCGAGGTAGCTCCATCGCAGTTGAAGAAATTCACCGGCGCCGGCGGAACTGCCGCTAAAGAGGTGGTTGCAGTGGAGACATACAAGCGCTGGGGCTTCCAGCACAAAAGCAACAACGTCACCGACGCTTATGTGCTCGCTCAAATTGTACGTGCTATACACGAGCCGGTGAAGCTGCTGAAGGTGCAGCAGGAAGTCATACAAAAACTGAGAGGATGATCTAAATGGTCGCTGCTAAGGGAAAGGCGAATATCGGAGGGATTACTGTAGGTTCTAAGAACGTGAAGATCGTTCTTGAGGTCAGCAAGCGTGATTTCTTCAAGAACGCGAAATTCTTCGAGAGTGACCCGGAAGAGGTAGACTTTGTTCTCGGTGACATGCAGATGAGCATATCCGATTATCTTGAATCATCTGCTTCGTCAAAAGAACTACTGGCGTCGGTGGGCAATTCAGATGTTAAACAGTCGGTAAAAGATGAAGACCAGGTAGTACTCTTTGATCAACAACATCAACAGCAGGGTTCGCAGGAAGCTCAGGCGGCGCCAAATCCTGATCTTGAAGTGAGCTTTGAAGACGGAAATATTCCTGCCGAGGGTGGACATGCTGCTGATGGCGGCGGTCACGCAGAGGGAAAAGACGAAGCTGAGGGTACAGATGAATCTGGATCGGAACCAAGCAAGGAAGAAGTCGAAGAACACATTCTGAAAGAGCAACCGCGATTCGATGATGTCGAGTTTGACCCATCACTCTATATCGAAAAGGTTGAGACGCAAAGTAGCTGGATGGATATAGCCTCGAAATATGGGCTTAGCTCCAACCAACTACAAAAGGCTTGGGGAAAGTATAAAAATAGGGTGGCAGAGAAACTGAAGCAGAAGGGGGCTGCTTAAAAATGGCGAGCGTTTATCGTAACGTCAGTCACTGCAGATGAGATGGAGCGCATTAACAGTGTTATGATCTGCATCGCTTAAGGAGGAGGCAATTTGTGCCTCCCCTACTATTCAAGTTGTATATGGAACAAATAGATTAGTGAAACGACAATAGGTATTGAGAGCCCGTAGGCTACCAAAGGTCGTTTATGATGCAATCGAATCATTGGAAACATCATGATATCGAATAAGAGTGAATACCAAAGACTCCAACTGTGTTGGTACGAGATCCTGCCCATTCTGAGAAGAAACCATTCACCAATTATGTAAATACCAATCCAAATCCCGTAGTGGAAGACTTTCTTACCAAGTGCTTTGGGATATCTTGAAAGAAATATGAGGACTGAAAGAGGCATAGTTACAATGGCATATACCACAACTGTGACAGTTTGGTTGTATAGGTAATCAGGGTGGAATTTCCACATTGTCTGGTCCTTTGTGAGGTACTCATAAAGGTAGCTTCCGGCTGTGATATATAGCATGGAGGGATGGTACAGTTTCCAGTTTTTCCAATCACCCCAACGCCATGCAGCAAGGATAATTATAATGGCATAAGCCAAATGCATAAGCGATCTCTCCCTGCAAGATATATCCAATAAGGGGGTTCTCATGACTAACAATCAGATTAAGGAGATACAGGAGGAATGCAGTCGATTATATCCCAGGGACTCACGCTGCAGCTAGATCAAGGTCTCAGACCTGAAGTTTCTGGTAGACACGATCCAAAGGCAGGCTGAGGAGATCAAGCGACTTGCCGGTATCGAGCATGCGTTACAGGACTTCGGTCCCCGTGTACGTCAGTCAGCCCAGACGTATATGATTGGCTTGAGTCAGTTAGTGGGTACCAGGAGGAACCGGTTGATGATCAACCTTGCAAATAAAATCGGAGTTCTGCAGGACGAGAAGGAATTCATCGTTGTTATTCACGGGACGTTTTACGGTCCATTTAAAAACGAAGAGATCGGGCGAATCCAGGATCTGTTTGACGAGGAGGTGCTGAGAAAATGAATCCCCGTAAGCTTCGCAGAAGATGCAGGCCACCGCTGAGCATGAATTATGGAATGCCACCCGCGTACTAAGGGACAAAAAGAGAACTCTTCCTAATTTGGTCTCCTGAGAAATTGTAAGTGCCACCTTAAATAAAGTAACCCCAGAGCATAAAAGGGAATCGAATACCACATTCTCCAACCCTTGTAGATAAGATATCCAAAGAGAACGGATATCCACTCAAATAAAAGAGAACAGCAGACTACGAGTATAAGATAAAACAAGAAACTGTGAGTTTTTTTGGGGTTGAAAATTTAGTGCTAATATGCCTGCTGCGGGTGGGAGAGCAGCCTGAAGAATTAAATCACTCAGGGTTATATCGGGATAAATGAAGTCATAGAGGTCTAGGATTAGGCCGAAGATTAAATCTGTATTTAGAGTAAGGCAAGCCATCACAAACCAAGTTGTATATATTTCTTTTCTGTTTAAACGCTTTGGCATCAAGAGTAGGGCCAAGATAAAAATTGCTAAGGAGATATAAGCAAATAAAGTTGCTTTATCCAGTGTCATAGTTGCTCCTACTCCTTATGATGAAATACCCCATGAGTGGCCATAAAACAAGTCGGATGTACTGGTCTCATTTATCAATATGGTCAAAGCAGTATTTATTCATACTTAATTCATGGAGGCCGAAGATGCATATCATTTCATATTACAAACACCCCACAGGAAATTACGTCGCCAAATACAATAGCCAATCCATCATGGTGCTGCAGACAGTATTTCGGAGGATCACGGGTGTAAGTCCAGCTTCAGTCAGCGGTTGGACTGAGGTAGAAAAGCAGGAATTGTCGCAGCTGGGATTCATCGCGAATTAACAAAAGGCCCCGTCGATCTAGGGGGATCGGCGGGGCTATGAACGAGTAAATCGCACAACCACAGTATACCATACGGTGAGGGGTGCGGGGATGTCGATATTGTTTAAGATGGAGGAATTGTTTCCCAAGGCGTCTAAAGCTGATATTATACGCACAAAAGCTTACCTCAGCCAATATAAAGAAAAGAAACGCCGGGTAGAAATGTTTGAACGTAATCCGCCTCAAACAGACGAATTGAAGGAGATCCAAACAAATCTGATTAAGTTCACCAGCCTCCTGGAAAGGGCAGTGGCTCAAATCATACACGACGATGTCCGTAAGGTGATCGAATACCGATTCCTAAAAGGAAATTCCCGAGCTGCCACAATCCTGCGCTTTGAGTCATGGGAGTGCTGTGATAAAACCATCGACCGCAAAATCATTGAAGGGATCGAGTCTGTTGCAAACACGCTACTATATCTGGAGTGAAGAAATTGTCCATTTACAGTCCAAGTATTGACCAGAAGATGTCTGCGCATGAAGGGTACAGTAGAACCAGGGAGCCGAGGTGGGCTCGGGTGATGTCTACTGTACCCTTATCATTGTAGGCACTCGGTCATGCTGTGGGACTTCGATCCTTAGACGCCAGTCGTCGAGGGTGTGATATGAGGGTGGGTGAAATGCCCTATGTATAAACAATGGAGAGTATTTTACATATGGTTGTGGGAAGTAAGCTCAGCTTCTAGGAAAGTTAATAGCAGGAAAAAGGCAAAGGAGCTGCTACGCTCATTTGCCTTTAGACACAAGAATTTATCCTGATATAAGATAGCGGAGGAACTAGATATATTATTGATTATTATTGAATCCAATCTACTGCTGCAATTCTGTTTGCAATCGGCTTTGTTGTAGTTCCGCTTCCGAGTTTCGTTTTGAATCCAATAAATTCTTTGTAAAAGTTAAAAGTGATATAGTTATGAACAGCATATCCTTGTACGATCCATGTTTTATTCGTTGGGATTGATTCCTCTTGAACTACTAGGGTAGCAGACATACCAGTTGATCCAGTGACGGAATATCCTACAGCAGCTGAAATAATCGGTGTAAGTGCCGCCTCTACAGTAGAGCTAAATTGATGCGCTACGCTACTATTAGCCTGTAACTGGGATTCACCTTTACATGATGGTACCTTAGAGCAAAAATATCTTGTTTCAGCAATAACATCACTACCAGTTAATGTTCCCCTACCTGTCTCTTCGAATATATAACCATTAATCTGAAAATTAGGAGAAATTCCACTCTTTGTGGGTGGTGTAACCGTGGCGGGCATAATCCTGATAGATTTAAGTTGAGCATTAGGCGAAGGTTTTTTCAAATTGAATTTTTTAATAAGATCATTTTCATTTTCTGGGGTAGCCTTAATGGTTTCAACACCCTGGGAAGGAAATCTTGGAATTTCCCCACCCTTTGCGCTTGCTGGAACTGCGAGAGCACTAAAGGAAAGGGAAAGAGTAAGCATCAAACCTGCAAGCTTTTTTTTCAAAAGATAACACAACCTTTTTCTATTATTTTCCTTACATGTGCTATAATAGCATAATATGGAAAAACAAATAGATTTCTAAAGGTAAATTTAGGAAACTATTTAATATAAATACAATATTGTAAAAATAAGTAAGGAGCGATTTGATTATGCCTGATAGAAATAAGGTGTTTTGGATTCTTTCAATTGTAGGATTCTTGTTAGTGATAATGAGTCCCCAATTAGCCAGTATTGGAGCTGATAACTTTGTTCATAAAATGGGGGGCGTTGCTGATAAAGACGAGACTTTAAGAAGATTAGAAACCTATGCTGCTGCTTATCGTATGTTGGGTGGCATCTTCCTCGGAATTGGATTGTACTTTACTTTTTCTCAAGAAAAAAAATAATCTCAATTATGGAGTGCGATTAAGCACTCCTTTTTGCATTATTTTTAGTAGGGATTGCTTTGTTTATATGATAACTGGAATTTATTAGATTTTTTGGAGGGAGTAAATGACGAGGAAACCTATGCGTCCATGTAATTTCCCTCTATGCAGTGAGTTGACTGCAGGAAATTACTGCCAGACTCACCAACAACAAACCGTCAGACTGTACGATAAGGCGAGGGATCCCAAGCTCGTTTCCTTTTACAAGTCCTCCTCTTGGTTATCAACGAGGCAAGCTGTTCTGAGCCGAGACAACCACTTATGCCAGCACTGCCTGCAGGAACAGCGACTAACGCCGGCAGTAATGGTTCACCACATCCAAGAGGTTCGTAAGGATTGGGAAGTGCGGTTGGATCTCGATAATCTGATTAGTCTCTGCGATGCGTGTCATAACAAAGTTCATAATTAGGATGAGTAGAAAATCAACGGATCTTTTGGTTAACAAATCTTTAGAATGTAGATAAAGGATTTGAAGGGGATGAGAAGGTATTTAGTTATGTACCAAGTTTAGGTCATTCTAAGGGAGTGATTAATATTAACAAAAAAACACCCCAAACTGAGAAAGAGTTGCTTCATCACTTAGAAGAACAGTTATATTTCATTAAAGCATCCTCAGAGGCATTTGATAAAGGTTTCTTAGGTGAAGCTAAGAGATTGGCTACAACAATTCGTGTATTACTGCATGATAATAAAACAAGTTCGCAATCTCTATTAAAACAACTAGACCAGAAGGATAAAATAAAATACTATTCTGTGCTTGAGAACAAAGATACAGATAACGCCATTATCTTTGTGGGTCTGTCATCGGGGTTCGAGAATGGGGAGTTTACTTACTATCCAAGGTTGGTGAGTCCAGTAGCAAAGCTGGACTTCCAAGAATGGTGGAATCAACCTGTACTAATAAATAAACCCCAGGGTTTGTTGTTTACTAGAGAAAGTATAATTAGAAACGTAGCAAATACCGATGGCGGTGCTCATGTAGATCCTGGTCTAAACGAAAAGTACTATGAGTTGTCCAGACAGAATGGATTTGGTTGGGAATTCCATGATGTTGAACCCCCATCCGAATTTAAAGGGCCTGAGTTATCTTTCACGCGTCAAATTGCTCATGAGTTATACATGTCAATTACAGAACAAATCCGTATCTAAAATATAAGTATTGTCGCTCAAATGAGCGGCTTTTTTATTTGCCCAGAGTCAAAAAAGGACTCCCCCCTACTTTAACAGTTGTCTTGAAGCCCCTTCCGGACCGACGGGGCCTCGCGTGCGAAAAAAATTCCCTTTTTGAGCACAAGGGGGGAAAGCAGTTAATCGTAAGAACGACGCAACGATGATACCCAAATTGTAGGGAAAGGAGGTGAGTTATGTATGGCTGGAAGAAAGGCAATGCCCGTTAATTTACTTCTGATCAAAGGGAAGAAGCACCTGACCAAGGAAGAGATCGAGCTGCGGCAGGAGAGGGAGAAGAAGCTACAGCCGAGTACAAACCGTACCAATCCACCGGCCTGGTTATGTGACACAGCCAAAAAGGAGTTCCGCCGGATCGCAAAGGAACTCAAAGAGATTGATCTGCTTACGAATGTGGACATCAATGCTCTAGCTTTGTATTGCGATGCCTATGCAGATTACATTGAGATCTCCAAGATCATTAAGAACGATGGATTCATGGTTGAGCATACCAACAAATCAGGAGTGACTAACGAAGTGGCACATCCTCTTCTGGCCAAAAAGAAGCAGATGCATGAGCAGATGCGATCCCTGGCTGTCGAGTTTGGGCTTACGCCGGCCTCGAGGGCTAAGATCGCCATGCCTCCGCGTGGACAGCCAGAGGAGGAAGACGAGTTTACGAGGACGTTCGGTGATGTATAATGCTGAAGCAGTTTCTTATCGATTACAGCCAGGATGTAATCAATGGCAAAGTGATTGCATGCCAGAAGCACAAGTGGGCGTGCATGCGTTTCCTCCGGGATATTGAGCGAGAGGGCACGGAGGAGTTTCCCTTTATCTTTGATGAAGAGCGCGCAATGCGCTTTTTTTTATGGATGAATCTCTTCCGCCACACGAAAGGCGTATTGAAGGGGCAGCGTATTGAGCCTCATGAAATCCAGTACTTCATATTTGGCAACATCTACGGCTGGATCCACATGGACACCGGGTACCGGCGGTTCAATAAGGCATACTGGCAGGTAGCCCGCAAGAATGCCAAGTCTCAGAGCAACTCATGTGTTGCCTCTTATGAGGCTTCAGCATTCGGGGAGTCGATGGCCGAAGTCTATTGCGCTGCAACGAAGCGGGAGCAGGCCAAGATCGTCTGGAGCGAAGCGGATTACATGATCAAGCAGTGCCCGGAGCTGAAAGGCAAGTTCAAAACATCCTACGGTATTATCCGGCATCTGAAGAGCAACTCCATCATCAAGCCGCTGAGCCAGGAGGATAAGAAGAAAGGCGACGGCCTTAACCCGCAATGCGGCATCATCGATGAATACCACGCTCATGAGACTGATGAAATGGTGAACGTTATTGACTCCGGTATGATTGCCCGGGCGCAGCCATTGATCTTTATCATCACCACAGCCGGCACGAATCTCAACAGCCCATGTTACCGGACGGAATACCAATTCGTTTCCCGGCTGCTCAATCCGGATGACCCGACCGAGGTCGATTCCTATTTCGCGATGGTGAACGAGCTGGATAAGGATGATGATGGGAACCTGATCGACGACATCAAGGATGAGTCTGTTTGGGTGAAAGCCAATCCCATTGCGTGCTCGTATCCTGAGGGCATTCAGAAGATGCGGTCGCGGCAGAAAGAAGCGCTCGAGAAACCCGAGATGATGGAAGACTTCATGACCAAGAACATGAACGTCTGGATGAGTCATCCGAAAAAGCAGTACATGAACATGGAGAAATGGGCTGCCTGCGGTATTTTGAAGCGCAGGAAATCGGATCCCGAGCTACAGCTGCCTGAAGTAAGAGGCTTTACCTGTTTTGCCGGCGTGGATATGTCCATGAAAATTGACCTATCCTCGGTTGGTTTCGTGGTTCCTTTGACAACGGGAAGTTTTTACGTTGGCCAGCACTCCTTTATTCCCGAGGAGACACTTGAGCAGAAGAAAAAGACGGACCGGGTTCCGTATGATCTTTGGATTCGCAAAGGCTGGCTTACGGTGATCCCGGGTGCTGTGGTCGACCAATCGGTGATCGAGAACTATTTGCTGGAGGAAGAAGAACGCCGGGGCTGGGTGATGAGAGAAATATGCTACGACCGTTATGCGGCAACACAGTTTGCTCAGAATATGGCCGCACATGGATATGAAATCGTCGAGATCCGGCAGGGGGTACAGACGCTCTCGGAGCCGATTAAGGACTTCAGAGAGCTCGTACTGCAGAAGCGTATCATTCATGAGGATGACCCGGTACTTACCTGGGCGCTCGGGAATGCCGTGACCAAGTCGGATGACAAGGAGAATCTGCTGCTGGACAAAGCTAAGTCCACCAACCGGATTGACCCCATAGCAGCAGTGATCAATGGTTTCGTGCGTGCTCGGGTGGCTCCTCCAGACAGCGGGGATGTGGAAGTCTGGACATTCTGAGCCGAAGCAATCTAGGGGAAAGGAGGGGGAAGATGGGGATTCTACAACGGGTCATTTCTTGGTTCGGCCTGGGTGCAAGGCTAGAGACCAGAGCGAATCGAAATCTAGGCGGGTTTCAAAAATGGTTTGAACCGTACAACATGTTTGCACGGTCCGGCCAACTTGATGCCTCGAATGAGACGATCTTTTCGGCGGTATCGCGGCTCTCAAACTCCATGGCCAGCCTGCCGCTAAAGGTCTTCCGCGGATATAAGCAGGTTAGCGGCTCGCCTATTGCGCAGCTGCTCGAATATGGGCCGAACCCAAATATGACAAGCTTTGATTTTATCCGGACTCTGGAAGCTTTCCGGGATACGAGTGGCAACGGATATGCGTTAATTGAGAGGGACGCCAAATACCAAGTCCAAGCACTGTGGTTGCTTAATCCCAGGAAGGTGAAGCCGGTTCAGGAGAGCAGCACGAAAGAGCTCTGGTATGAGGTTCAGGGGGATGACGGGACTTACTATATCCATAACATGGATATGATTCACGTCAAGCACTTCCACACCGTGGGATATGAAGGGATTTCGCCGCTGGATGTACTTCGAAACACGATCAACTATGACACGCAGGTAAAGCAGTTCAGCCTCAGCCAAATGGAGAGCGGGATCAAGGCTTCGTTTATTCTAAAGCTTAACGGCTCCTTGAGCGACGAGAAGAAGAAGGCGATGCTCCAGAACTTCGCAGACTTTTACTCCAAAAACGGCAGCGGCGTGATCGTCATTGATTCCGGCCAGGATTTAAAGGAACTGAAGCAGGACATCATTGACCTGAAGGTATTCGAAGTGGAGCGAATCACGCGCTCTCGGGTGGCCGCAGTGTACAACATGCCGCCTCACATGCTCGGGGATTTCTCGCAAACCTCCTTTTCCAGCATGGAGCAGCAGGCCCTGGAGTACGTCCAGAACACACTGCTTCCGATTGTGCGGATGTACGAGCAGGAGTTCAGCCGAAAGCTGCTTACCACAAAGGAGCGGTCCGCGGGGACGGTAATCAAATTCAATATGAATGGACTGCTCCGTGGCGACATTAAGACGCGCGGAGATTTTTATTTTAAAGGGGTCCGTTCGGGGTGGTTTACACCCAATGAAGTCCGTGCTTACGAGGAACTGCCGCCCGAAAAAGGGGGCGACAAGCTGTATATGAGCAGGGATTTGGCCCCGATTGACAGTCCAGACCGGTCCATCGCACCAGGAAAGGAGGTGAATGAGCAAGATGAATCAGAAGCCGACAACGACACCGGATCCGAACCAGAATGAAGTCCGTACGCTGAAACTCACCAAGCTGGAGACAAGGGCGCTCGGAGACGAGAGCGGCACAGGTACCAAGATCACAGGCTATGCTGCCGTTTATGAGGAGTTCACCGAGCTGAGGGATTGGTGGGGGGATCGCTTCTATGAACGGATCGCCAAGGGGGCTTTTGATGATACGCTGGCCGACGGACACGACATATTCGCCTTGAAAAACCATGATTGGAACCTCATTTTGGGCCGTTCAGGGGCCAATTTAACTCTCGAAAGCCATGAAAATGGGCTGTATTTTGAGCTTTTACCGAACAATTCGAGCCTCGGACAGGACATGAAGGAGGATGTGCGGAGCGGCCTGATCAAAGGCTGCAGCTTTGGATTTCGTATCGTTGATCAGGAGTGGGAGCAGCGGGATGACGACTGGTTTCGAACCATCAAAAAAGTGGAGCTTCAGGAAATCACCCTTACGCCTATTCCGGCGTACTCGTCCACTACCGCGGAAGTACGGAGCTTGGATCGTCAAGGCCAGCACAAAACTGCCTTGGAAGTACCGGATTCGCAGCGATTCTCGGTGCCAAAAGGCTTATCTGAGGAGCAAATTCGGGCCCTAAAACGCAAAAATGAGGCCCTTTTGCTTGATATTGAGACCACTTTAAGGTATGGGAGGGCATAAAATGCCAGGAGAAACAACGATTTTTCAACTCAAGGAAACCTTGAACGACATGGGAACGGAGCTTCGTTCCATCACCAATAAAATTGATGAGGCCCTGACGAATCCGGCGGCGCGAGTGGAAGAAATTGAACAGATGGAGGTCCGCCAAAGAGAGCTCAAGAAACGCTTTGATGCCATTAAAGCACGGATCGAAGAAAGGGAGCAGGAAAGCCAGCGAAACCTCGAGCAGCAGAAGCGCGCAAACCCGGTTTTACATGCGGATACGGACGAAAAGCGCATGATTGCGGCCAAAGCGGAGCTCATCCGGGCAGAAATTCTAAGAGGGCAGGTATCCGATGAGTCCCGTAACCTGCTGGGAGCGATCAAGCAGCCTACAGCAACCGGCGGAGAAAAGTTCCTGCCGACGAACATGAGCAACCAGCTGATCACGGAACCCCTAGCTAAAAATCCTCTTCGCAGCATGAGCCCTACTACAAAAATCAAGGGTTTGGAGGTCCCTAAAATCGCATATGAGCTGGATGATGACGGCTTTATTGGCGATGAGGAAACCGCGAAGGAAATCGAGTTGACCGGTGACAAGGTTGCGTTCGGACGTCACAAGTACAAGGTCAAGGCACGGATCTCGGACACTGTTCTTCATGGATCCGACGTGGAACTCACAACCTACGTAGAGAACGCACTGCGGTCCGGCCTTGCAGCGAAGGAAAAGAAAGTGGCACTAGCTACCACCCCGAAGGCGGGGGAGGAGCATATGAGCTTCTACTCTACGCAAAATGCGATTAAGCAGGTACCAGGCGCGGATAAGTACAAGGCGATTAAAGCAGCGATTGCGGATCTCCATGAGGATTACCGGGAGAACGCTAAGGTACTCATGAAGTACTCTGATTATCTGGACATTGTGGAGACGCTGGCTAACGGCAACGCAACGCTGTATAGTGCACCACCAGAGCAGGTTCTTGGAAAGCCGGTTGAGTTTAGTGATGATGCCACGATGCCGATTGTTGGCGACTTCTCCTATGCCCAGCTGAACTATGACGGAGATCCCGTTTACGACACAGACAAAAATGTGGACAAAGGCGAGTACCTCTTTGTTCTGACCGGCTGGCTGGACCACCAAATCCTGCTGAAATCGGCCTTTCGGATTGCCAAGGTAGTTGCAACTCCATAGAAAAGGGTGATGCTCTATGCTGAGCCTGGACCTTGATGAACTGAAAACGTACCTGCGGGTAGATGGGAGCGAGAACGATGGATTTCTCGCTCTTTTGGTTCACTCGGCCAAGGAATACCTGAAGGATGCTGGGGTTCCCGAGTCATCAAGTGCAAGGTACAAACTCGCCGTCATGATCCAAGTAGCCTTGAACTATGACCGGGACGGTAATGCAGCTCTGGAAAAAGCGCTAGAAAGCTTGATAAATCAATTAAGGGTAGGTGAGCCAAAGCATGGCGGGAGCGAGCCAGAAAACCTCCTCGAAGGCACCTGTGGAGATGGTATATAGGGTCTTGGTGGAGTTTATCGACCGTGATCAGCGATATTATCCGGTTGGTGATGAGTACAAAACAAAGGATCAGGACCGGGCAGGGTACCTCGTTGAGCTTGGATTCCTGGAAGCCCCGGCTGCTGCTCCCAATCCGCCTGCACAGCCAGAGGGGCAGACCGGAACAACGGTGACCGATGAATCCGGCCAAGTATAATCGCCGCATCCACATCCTGCAGCCGGTACGGGGAGAAGACAATGAAGGGATACCAGTGATCACCTGGGCCCCAATCATTTGCTTGTGGGCAGCGGTAAAGCCCCTTAGGGGACGGGAGTATTTCCAGGCCGCAGCCATCAACCAGGAGAACACCTTAAGGGTGGAAATTCGGTACCGTACAGGCATAACGAGTGAGATGCGGGTGCAATATGCCGGCAAGCTCTATAACATCAACGCGATCCTTGATCCCGATGAAGCCCATAGGGAGCTTCACCTGATGTGTTTGGAGGTGCAGGAACATGGCGGAGATGAAGCTGGAGGGCATGGATGAGCTGGTGAAACGGCTGCAGGAGATGGGCCGGAAGGGTGCAGCCATCGAAAGAGCAGCACTGCAGGCTGGCGGCGAAGTCATTCGGAGTGCTGCAAGCGAGCGGGCTCCGCGGAGTAATGATGCTCCCCATTTGGCGGATAACATCAAGATCAGCAAGATCAAGACCAGCCAGGGCATGAAATATGTGCTGGTCGGTCCGCAAAAAGGGGATAACTCCGAGTTTTTCTACGGTAAATTCCTCGAGTGGGGAACCAGTAAGATGGCTGCACGTCCGTTTTTGGGCCCTGTTGCGGCCGAGAAGCAGGGGGAAGTGATTGAAAAGATGAAGCAGGCGATCAAGGATGGACTGGGCTTATGATCAACGTCAAACCAGAAGTATTGGAATCTCTTCGAGAGGACGAGGAGCTTCTTTTGTTACTCGGGGGCCCCCGGGTATACCAGCTTGTTGCACCAGAGCCGGGCAAGTTTCCGCGGATCACGTTTTTCGAGGTCAGTAACGTTGACGACAGCTATGCCGATGATTCTGCGATCTCCAGCCAGATTGTCATTCAAGTTGACGTATGGAATAAAACCAATACGTCAGCCATAGCGGATCGGGTAGATGCGGTCATGAAGAATATTGGCTTTTCTCGCTCGGGCTCCGCTGACCTCTACGAGAATGACACAGGAATCTTTCACAAAGCAATGAGATACACAACACGAAGGGAGGAGGTTTAATCCATGGCTGGAGTACGCATAGGTCTAAGAGACCTGCATTATGCCAAACTGCTCAGTGACAACAGTTCAGGGGCAATGTACGCAGCACCGCAGAAGATTGCTGGTGCCATCAGCGCGAAAGTCACACCGAGCTCGACAACCGAAACGCTCTATGCTGATGACGGCGCGGCAGAAACAGCAACGGCCTTGGGGGAGATTGCCGTTGAGCTCAATGTAAAAGATCTGACATTGCAGCAGCTGGCGGATCTTCTCGGGCGGACCGTGGTCAATGGCATTATGGTAAGTAAGGATACGGACACGGCTCCGTATGTTGCCATCGGCTTCCGTTCGATCAAATCGAACGGGAAGTTTCGGTATAAATGGCTGTTCAAAGGACGTTTTAGCCTGCCGGCCGAGGAATATAAGACGCAAGGAGACAAGCCTGAATTCCAGACTCCAGTGATCAGCGGCGTCTTCGTCAAACGGGAGTTTGATGGATGGTGGGAAGTAACCGGCGATGAAGATGAGCCAGGCTTTACCCTGGGCGATACCTGGTTCAACAAAGTATTTGAAGCCGGAGATTCGGAAAATCCAACGTTGCCGGTATTTGTTTCGGCGAACCAAGTTGTCTTTCAATAAGAGAAAAGGATGGTGGATCGATTATGCCAGCACACAGCAAATCATTGTATCGTGACGGGGCTCAGCTGCCTGCGCCTCAGTACTTCAACCCTGTAACCGATTCGTATGAGCCCCTTCATGGAGCGAATGGAGCTTCGGACGTCAACGTGAAGGGAAGCTCGGCGATTAAAGATGGGGTCCTTTCGGTCTCTGCTCCGGGAGTGCGAGTACAACTGCCAAACATTCCATGCCGGGAAGTCACGGTTATCGCAAGGAAAAACAACATAGGCACGATCTATGTTGGCTCCGAAACCGTCTCGGCAAGCTCCTTCGCCGCCGAACTGGATAAGAAAGACGCGATCACGCTGCCGGTAAGCAACGCGAGTATGCTTTGGATTGACGCTTCCGTAGCCGGAGAGGGGATCTCATATGTCGCGCTTTAAGCCTTGGCCGGGTACGAACGCGAGTCCAGGGGGAGGCTCGGGAAACGGATCTCTTCCCCGAAGTTACGAAGGTATTGAAGTGGTTTGGTGGGGCAACTCCATCATCGAGGGACAGGGATTGACGGACCTGCAAAAGTTTCAAACGCAGCTTGCCAAATTGAACGGGATGGTTAACCGAATCTATGGGTATCCCGGCAAACCGTGGGGTTATAAAGGCACCGGTCCCGACGATACGATCTACTCGAACAGGGCGCTGCTTCCGAAAACGGCAAAGCTCTACGCGATGTACGGTGGTGGAAACGACAACCGGTTAAATATCCCGCGGGGCAACGTGGATGACATGGTAAACACCACTTTTGCGGGCGCAATCAACCTGGGCATCGTTTATATTAAAACGAACATGCCCGGAGCAAAGATCGTCCTGATTACATCACTGCAGCGCAATGGTGGAGACGATGGAACGGGAAAGCCAATCACCGGTACAACATTGAACGATCTGAAACTGAGCCTGATCGATTACAACAATATGATTTTGGCAATCGGGCAAAAGCACGACATCCCGGTTTGGGATCTATACAATTGCGGCATCAACAATGCGAGCATCCCGAAATATATGCAGTCGGATGGTGTTCATTTAAATGCCCAGGGAGCGGCCAAAGTGGCGCTGTGCGGATATGGGTTCTTTGAGACCATCGATTTGTCGATCGTTTCCCCGCCGGCTGACACAACGGCACCAACAGTACCAGGGAAACCAACGCTGACGAGCAAAACTCATAACAGCGTTACGATTGCTTGGACAGCGTCTTCCGATGCAGTGGGTGTAACGGGCTATATTGTGACGGGCGGACCAAGTCCTGTAAACGTCACAGGCACTTCAGCGACCATTCCAGGACTGACTCCGGAAACGAACTATACGCTTTCCGTCAAAGCTAAGGATGCAGCGGGGAATGTATCTGCAGCGTCAGAGGCTCTGACGGTAACGACCGATGCGGCGCCAACGGGCGGCGGTGGTACAACGGTAACGACTTATTATGAAAATACCTTTACCGGGGCCGATGGATCCGCAAATGGGCAAGTCGCAGAAAGTGGACAGGCTACCAACACCGCAACCGCAGTAACCCCGGATAACTGGGTGATTTCGGGTAACCGGATGAAATATTCGGGAACGACGGGGGACCGGATTATCATGTCCACTTCCGCGACCGGTGGGGACTATACAACTGAAGCTCAGATCTACCCTGCCGGAGGTAAAGCCGGTGTGGTTTTTCGGGCAAAAGATGGAACGGAGTATATGTGGGTTCGGTTTGATCAGGCGGGCAATGCCGGAGAAGAAATCAAGATGTTTAAGAAGCACGAATCGACGGGAGCCAATACGCAGATCGCCGCAGGCCCAGTAAAGATCAACACGACGGGGTCAAATATCGTGAAGATTGTTTGCGCAGCGAACAACGTCAAAGTCTTTGTAGATGACAACCAGGCAATCAACTATACCCTGACAGCGGCAGAACAGGCCAAGTATGGTGATAATACGGGAGTCGGACTGTACGCGGGCGGTGAGAACGCCTCTACATGGGAATACCTTAAATCATATTCGAACTAATCCATCGATAAGTGGGGCGCGTAGGCGCCCCTAATTTAATTGAGGGGGCACATACATGAAACTCGTTCTGCGGATCAATGGAAAGCCAAAAACTTTCACCGTTTCATTTGTGAGCGGCCGCATGCTGCGTAAAACACTGGAAATTTCCAAAAACACAAATTTTAATAACGTAACGCTTGAAGCGTTAGATACCTTGGTTGAATTTGTCGTGGAGCTTTTCGAAAAGCAGTTCACGGTGGATGAATTCTATGACGGCATCGAGGCCGATAAGCTACTGCAGTCGGTTATGGACTGCATTTATCAAGTCACGGGTAAGGCAGCCAAAGCATTAGAGCCGCTGAGCGACCCAAACGCATAGAAGGGGACACAGACCCCACCGACACGATTAAAGAGATTTACATCTCCCTCTTGGATAGCGGATGGACCCTCGAATCGATCGACAATATGGACATTATCCATTATTTCGAGCTGCTATCCTACAGGGTGAAGCCGAAAGAAGCCCCTATGGTTTACATCGATCACATCTTCTAGCCGAGAGGAGGTGAGGAAACAATATGGCAGAGGAAGAAGCCGGCAGTGTGGTCGTTAAGGTCGGCATGGACGGCTCAGGCTTCCAAAACGGCATAAGTAACATCAACCGGCAGCTGCGCCTGATCCAAAGCGAGTTCGCGGCGGCTAGCGCTAAGCTCGGGGATTTTGGGAACAGCGCGGAAGGACTGAAGCTGCAGTCCGATGCGCTGTCCAAGCAGATGAGCCTGCAGCAGCAGAAGGTCGACGCACTGCAGAAGGCTTATGAGAAGGCGGCGGAAAGCAAGGGAAAGGACGCGAAAGCCACCCAGGAGCTTGAGATCAAACTCAACAAGGCTAAGGAAGAGCTGGCGAAGACTGAGAAGAAGCTCGAATCGGTTAATGAGGAGATCGAGAAGCAGAATAACCGCTGGAACAAACTGGCGGGCACGCTCAACGATATCAGGGATCGGTTTCAGGCGCTCGGAGATCAGCTGTCCGGCATTGGCGGCATGCTCAGTGCCACGCTGACTACGGCACTCGCCGGCATAGGTATCGGGGCGATCGGCGCAGCGTCCGATGTAGACAAGAGCGCAGGAAAGATGCAGGCGAGCCTGGGTCTGACGGCTGAGGAGGCCGATAAGCTCAGTGCGACAACCCAAAACTTGTGGAAAGATGCCTTCGGGGAAAGCATGGAGGATGTGACTCAGGGCCTCATCACCGTAAAGCAGAACATGCAGGGACTTGATGACGGCAGCCTCGAGAAGGTCACAAAGGATGCTTTTACATTGAGGGACGCCTTTGGCGCCGAGGTCAATGAAACCACTCGCACCGCCTCAGTACTGATGAAAAACTTTGGGATCGATGGCTCCACGGCGATGGACCTGATCACTGTTGGCTTCCAAAAAGGCGGAAACTTTAGCGACGAGCTGCTGGATACGATGCGCGAATATGCTCCGCAGTTTAGGGCAATGGGCATCGGTGCTGAAGACATGCTCGGTATCCTGATCAAAGGAGCAGAAACCGGAGCTTTCAACCTCGATAAAGTCGGTGACGCGCTGAAAGAATTCAACATCCGAGCGAAGGATGGAAGTGAGCTGACCTCTCAGGCATTCTCTGCTTTAGGGTTTAATGCGGATGAAATGAGCGCCAAGTTCGCCGCTGGCGGAGAGACAGGGAAGGTGGCATTCCAAGCTGTCACCGTGGCTTTGGCCGGGCTGCAGGACCCCTTAACGCGCAACGCAATCGGTGTTGCGCTTTTTGGCACGCAATGGGAGGACCTCGAGGCAAAAGTCGTCACTTCCATGGCCACAGGAATCGGATCCGTAACGGGATTTCAAGGGGCGACCCAACGTGCAGGGGATGCCCTGAGGGATAACCTCGGGGTCAGGGCAACCAAGGTGTGGAGGGAGTTCCAGACAGCCCTGCAGCCCCTCGGGGAGATGATGATCGGCTTGGCTGAGGAGATCCTTCCGCAGGTAAGCGCGGCGGTGCAGTCCCTGACGCAGTGGTTCTCCAACCTTTCGCCGGATGGCCAGAAGCTGACGCTTGTGCTCGGAGCAATCGCCGCGGCAGCCGGGCCTGTCGTGATGATCGTTGCTCAAATGGTGGGAGCTGTTACAACCCTCATTGGCGCCTTCTCTGCAGTTTCTTTAAAGATAGCAGCCGCCGGTGGGGTAATGGGATTACTCACCGGCCCGATCGGCATTACGATTGCATCGATAGCGGCCTTGGCTGCGGGTGCCTACCTGGTCGTGAAGAACTGGGATCAGATCAAGTCGTTCTTCTCGGGACTCGGCTCCTGGCTTTCATCGTATTTCAGCAATCTCGTTAGCACCGTCACCACATACGGCCAGTTCATCATGACCGGCCTGATGGCGGGAATAAACAGCAAGCTGCAGCCGGTCATCAACATGATTACGGCGGTGGCCAATGGCATCACGAGCTCCTTCCGGCGGATCATGGGCATCCGTTCTCCATCAAAGGTGATGGAGGAATACGGCCAGTTCATTGATGAGGGGCTTGTACAGGGGATGGCCTTAGGTCAGGACTCGGTGCTCGAGCAAACCCAAAGTATTGCCGATGGGATCAAGCAGACGATGGAGAAGAACATCGGCATGCTGAACAAGCTCGGTGAGGCGATCGTCGGAGCTCTGCGCAAGCAGTACGAGGAAATGGAGAGCATCCAAACCGCGGCGCTGGACAAGCAACTTGAGAATGAAAAGAAAGCCTCGGACGAGCGGCAAAAGGTCTACGACAAGGAGTACGCTGAGAAGCTGAAGCTCATTGACGAAGAAACCTACAACAAGGTCAAGGCCGTTCAGGACCAGATCGACAGCATCGACAGTCAGACAAGCAATGAGGAGAAAGCATTAAAGGCCCAGGAGGAGCAGACACGGCTCGCCGAGCTGCAGAAAAAGATCGCGGCAGCCGAGACAGCCGAGGAACGGGCTCGCCTGCAGGAAGAACTGAGCAGCACCATTGCCAAGTATGAACGGGAGCAGCTACTCGAGCAGCGGAACAACCAGAAGGAAACCCTGAAGAAACAAATCGAGGGGCTGAAGGAAGCATCCGCCGAGCAGAAGGAGATGCTGAAGGCCGATCTGGACAGCAAGAAGGAGCAGGAAAAGCTGCGGGCCTCGCAGGTGGAAGAGTCGCTCAAAGCGGAAAAGGATGCGGTCAAAAAGCACTTTGACGAACTGACGACACAAGAAAACCTGCAGCTGGAAGCCCGCAAGCTGGTGGTCGATAAGAACAATCAGGAAATCGTCGACTTGCTCCAGAAATACAATCCGAGCTGGCAGAACGCGGGCCAATCCTTTGCAGATAGCCTGATCAACGGAATCAACTCGGAGAAGCAGAGCATTGCCGATGCAGTCGGTAAAACCATCGATCTGCAGCCTATGGTGCAGAAGCAGATGAGTGTACTGGATGAGCTTCAGAAGAAGATTGCCAGCCTGCAGCAGGCCGAGAAAGCGGAAGCCGGCGCAGCAGGTGAAGAATCTCCTTTCCCCGACTCAGGAGGGTTTGCGGGCAGCGGCGGTGGGGATATAGGAGGTCTTGGTGCTGCCGCGGATAACACCTCGGCCAAGCTTGAGGGACTGATGCAAACCACTACTACCCTGCAGCAGGACCTCACAGGTAATTTCATCCCCTCGGTCGAGGGTATAAGCGGGGCATGGAACGGGGTTATGAACAGTTCGAGTAATGTGTGGGGTCAGATTACAAGCAATCTTACCCAGACATGGGCCGGCATCGCCAGCCAAGCACAGCAGGTGTGGTCAGGGATTACCGGCTTCTTCACATCCTCGTGGAACTCGTTTTTGTCCGTCGCCACCTCGGTGAGCAATGGCATCCACACGGGTGTGACTGACACCTGGAACAATATTTCTGCTCACATCAATTCGGTTGTGTCCGAGATCGTCGGCACCGTGATGACGATTTTCGGGGGAATGAGCGCTGGCATTTCGTCGGTGTTCAGCGGCATTGAATCGATTATCTCGGGCAGTTGGACCGTCATTAAAAACGTGACACTCGGTTCCATCCTCTTGCTGCTGGACCTGGTCACCTTCAATTTTACTGAACTGACCTCTCATGCCGGGCAGATTTGGGAGAACCTCAGAACGGCCTTCCGGCTGATTTGGGAAGGCATCCAGCTGGTCTTTACCAGCGCTCTGGAAACACTCAAAGGCGGTTTGGCTACTTCCTGGGGACTGATGAAGACGGACCTGATACAAAGTTGGAACGAGGCGGAAGCTTACCTCTCTACGCTGTGGGTCAATATCATTGACCAGGCGAGTACGGGCTGGACGGACTTCAAAACGTCAGTCACCAAGCTCGTGGAGGAGACGATCAGCAGCACCCGGACCAAGTGGGATGAACTTCTGAGCTGGTTTGGGGAGCTCCCCGAGAAGCTCAAGGGGTACGCCGAGAACATGTTCCGTTCCATGCGCGATGGCTTCAACAACACGGTAAATGAGGTTACCAGCGCTGTCAGAAACGGTCTGGACGGTGCCTTTGATTATATCAAGAAGCTGCCGGAGGAGGCCCTGCAGTGGGGGAAGGACATCATCGAAGGGCTGATTAAAGGTATTCGATCGGCAATCGGGTCCGTTAAAGCTGCGATCGACAGTGTAGCGAGCACCGTAAAAGGCGGCATCACCGACGCGTTGGGCATCCGCTCGCCTTCCCGGGTGATGATGGAATACGGCGGATTTACCACGGAGGGCTTCGCCCTTGGGATGAAGGGCGGACTGAGCCGTGTGGCCAGTGCTGCACGGACCATCGCCAGCGCTGCTTTCCCTAAGGTGGATCTGCCGAATATGGCGGCACCTGCGGGCAGAACGGCAGTGCCAGCGTCCTCATCAGGTGGCTTTGTGCAGAACATTACCATCAACTCTCCGCAGCCTCTTTCGCCGGCTGAAACGGCTCGGCTGAACCTGAGGGCAAGCCGGCAGCTTGCGATGGGATGGGGGTTAGACGGTGCGTAAGATTTCCTTTACCAACGCGAACAAAGAGCGTATCGTGCTTCAGAGTACCGGCCCATATTTCCTGACCAAGCTCGAAGGAGTTGCGGCAGTCCGCACAACGGTGCAACTCAACAAATCACCTTTCCAAGACGGTCAGACTTACCTTGGCAACAACCTTGATGTTCGTGAGATAACGATCGAGGGATCGATCGTGCCCGGAGCAGTGACGTTAGAGGAGAGGCGCCGGACTTTGATGCGGGTTCTTAACCCAAAGCTTGGCCTGGGGATCGTCCGGTATGAGGATGCCGGCGGGGCCAAGGAGATCCGGGCAATCGCAGAGGAATCACCGGTATTCCCAGATAAACAGCACGGGGTCTATCAGAAGTTTCTGATTTCCTTCCTGTGCCCGGATCCGGCTTTTTATGATCCGAGGATTCAAAAGGTAAACCTGGCCTCCTTTACTGGCGGCATCTCCTTTCCGTTCAGCTTCCCAATCAGCTTTGGGCGCGTCGGCCAGTTCATTACGCTCAACAACCGTGGGGACCTTGACGCCCCGGTGTTTATTACCTTTCTCGGGCCGTTGAAGAATCCCGTGCTTGAGAACAAGACCACGGGCCAGATGATCAAGCTGGTGCAGGAAATCCCAGAAGGGCACCGGCTTGAGATCAATACAGCATTCGGTAATAAGACGGTGACAAAGATCGCCGAGGACGGCACTAGGTCCAATGCGTTTCACTGGGTGGCGCCGGAATCCGAATTTTGGGGGCTGGTACCGGGAGAGAACGAAATTTCTTATCAGGCAACAGAGGAATCGAAGTTTGGCGCTGTGACTCTGGAATACCAGCCGCGTTACTTGGGGGTGTAGTAGTGAACAAATATCCCGCCCTTATCTTTGATCCGGAACTGCGTTATCTCGCCCAGATCGACAATTACGAGTATCTGCAGTGGACGCGCCGCTGGCGTAACCCCCACACCTGGGAGCTTCAGATTAACCGAAATAAAACAAACACCCAGTACCTCCAGGCTGATAACTTCATTGCCGTAAAACGCGGGGGCAAGTGGCGTGCCGGTATCATCGCACATCGGGAGCTGCCGCTGACACAAGAGGGCAAGCTCTCGGAAACCTGGACGGTGAAAGGCAGGGACTTCTCCGGGGTGTTCCTTGAACGTCTGGCATTGCATATGACGGATACCGGCAGTGGGTACGATGATCAGCGAGGCATCGCGGAACAGGTCATGAGGCATTACGTGAATGTGAACTGCATTGAGCCGAGTAATCCGGACCGTGTCATACCCTTCCTGCAGCTTGGGTTGAACTATGCCCGGGGGCAAACGGTAGAGATGCGGGCACGGTTCCAAACGGTTGCCGCACTGCTTGAGAACCTCTCCTTTGCTTCCGGACTCGGATATGAGACCTTGTTTGACCTGGAGTCCACCTCATTTTCCTTTAACGTTCTCTCCGGCCGCAACCTGACGCCAGGCCAGACCGAGCATCCGCCGGTGATCTTCTCTCCGGAATTCGATAATGTCGAAAGTATGGCTTTCCGTCATAGTATCCTGGACTCCAAAAACGTGGCGATTGTCGGCGGCAAGGGGGAAGCGCAGGATCGGCTAGTGGTCTCCGTTGCAAACGGTTCGCCCAAAGGTCTGAAGCGGCGAGAAGTATTTATCGATGCACGCGACCTGGAGACAGCAGAGCAGCTGTTGCAGCGCGGAAATGAGCGCTTGGCTGAATATGGCGAGGAGCTCGTCATGGAGTTCCAGCACCTGCCCTGGGGGCCCTTTAAATACGGCGTCGATTTCGATCTGGGTGATATTGTCCACGCTCGGTATCCGGGCGTAGGCAGCACGGAATCCCGAATTGTGGGTGTGGTCGAAGAGCTCACGCCGGATAAGGGAGAAGCGGTCAGGCTTGTTGTCGGTAAAGAGTGGCCGGATCTGGTCAGCGTATTAAAAGCAGATCGAAGAAATTTGGAGACGGAGGTGAGAAGATAGCATGACGGAGCAGTATCGTTTTTTCGGCAGCACCGAGGGGGACGTGAGGGAATACAATCAGCTCGAGTTTGCGGAGGTCTTTGACCGGTTCTTCCAGACGGGCATTTTCCCCCGGGTTGGTGCGGAGCTCAAGGTACTGGAAACCGACCCCCAGCGGCTTGCCGTCCGGGTAAGTACTGGACAGGCATGGCTGCGGGGCTATTGGTATCGTAATGATGACTTCAAGGAGATTGAACTGCCGCCGGCACATCCGGAGTTCCCACGAATCCATCGCATCGTCGTTCGGCTGGATACGCTGAATAAACGGGATATCATTGCCCTCGTTAAGGCAGGCGAGCCATCGGCGACCCCCGTCCCTCTTGCGCTGGAGCAAAATGAGGAGTACTGGGAAATCGGTTTGGCTGACGTTTATGTGGCTGCGGGAGTGACGAAGGTCGATGCAAGCAACATTACCGATATTCGGTACAGCGGCGGTGGCGGAAAGGCGGTTGGTCACGACTTCACCGACCTGCAGCTCCTTGCCGATCAGGCCGTTGCCAAAGCGAATGCAAGTCTCCCTAAAGACGGCAGTCAGCCCATGACCGGCGCACTCCGGTCAGCAGTTGGATCTGCCTCCGGCGGGCGCGTGCATCATTACCTGGGGAGCACCAATGATGTCCATCGGGTTGGCATCGGCTTGGATGGCGATGAAAACGGGGATGATCAGGTCGGGTCGGCCTTCACCGTGTGGGCCTACAAGAATAACGGGCAATACCACAAGACGCTGATGCAAATCTGGCGCGACGGCACGGCCTTTATTGACGGGAAGCGTGTCATTCTGGCGGACTCCGGAGGAAGCATTGATTCGGCCATCATCAAGAATTCCACTATCAATGACTCCACACTCAATAACCCGCGAATTTTGTGGAATCGTGATTCCGACTATGCCCGGCTGGAGTTTGTGGACGAGGGAGCTAACAAGGATATCCTCACCTTAACGGTAGGTGATGATGCTCAAGGGTCAGATACAGGGATCGAGGATTTCTTCCGGTTGAAGTTCGGCGATGATACGGTGGCCCGTTTCCGCAGCCAATCCCTAACCATTGGTGAGCCTGGTTCAGGTTTTGAGATGTACAAGAATGGAGACCTGTGGCAGCGCGGCGAACTCATGGCCCCTACAAGAGTTAGAGGGGGAGTCATGGAATATTGGGACGGAGAAAGATGGAGGGCGGCAGGCATGAGTACAATCGTGGTAAGTGGCACGGTACAGGAGACCATTCACGGATCGGCAGCCGACTTCGCGGGCGGAAGCTCCTATGGAGGCCGGAAGTTTCTAGTGGCGAAGCACATACCCAAAGGCGTCGGAGAGCTCAATATTGTTGTGGACTTCTACAACAACACAAATTCAGGAGGTGGATATACAGGGATTCAGGTTTTTTCTCCCGTGCAGCATATGTCAAACAGCAGCACGAGTGGGTACTTCGCGCGGGAAGCGTACGATGGGTACGGTCCTTTGTGGTGGCACGCATACGGGACATACTGGGATACTGACTCGGACTTCCGATGGAATAGCAGTTTGGTTGGCGGCACAGGCGGAAGTATGGGCGCCAGCTCATGGGCGACATACGAAACGACGGTGAAGGTATCGACAAAAATGCCCATTTACGTTTTGGGATACTCGAGCTTGGGGGCATTCAAAATTGCCAATGTTCGCTTTCGATACGATGTTCTATAAGGAGGGAGACCATGTACGCCATATACAATGACGGAGGACGCCCCAATGGCATTATCCCAAATGTGACCGAGGAAATGGCTGCAACTTTGCCACAGCAGTATGTGCTGTTCGACGGAGATCCCCCGGAAGTTCCAGCAGGACACCGCCTGATGGTCAATTTCGAAGCAAAGGAAGTCGGCACAGAACCTATACCAACGCCTCCGAAAACACCTGAGCAAGAAATCGAGGAACTCAAGAATGAGATTTCCGTTCTACGTACGACTGTCAACTATCTCCTGGGAGTCTAACTGAAACGGAGGGGAATTGGATGCCGAGCATACTTTATCCGCACTTTGAGATCTGCTGGGTCAAAAAGGCCGTTACAGCAGCTCAGCTTCAAACTGCTGTAACGAAAAAGTACATTACCGAAGAAGAAAAAGTGTTGATTGTAAGCAAAGAGCAGAGGGACTGAAGGGGGACTCAATGAAAGGAGGTGATACGGATGACTAACGATACGAAAGCGCTCAGTGACCAAATTGTAAACGTTAGGCTCGACATTAGGGAACTGAATACGAAGATGGACGGTATTAAGGACCTGACCAAAAAAGTCGAAGAGGTCCACGATACGGCCAAGGAAGCACTGGCCAGCACCAAATCTGCTCATAAAAGAATCGATGAATTGGTGCCGGTTAGCACGCTCGTAATTCAGAATGAAAAGGAAACAGATCGAGCCAATAAACGGTTAGATTTTTATGATAAGCTGGCATTTTGGTTCGGCACATCGATCTTGGGCAGCGTCATCTTAGGCGGCTTGGGATTGTGGAAGACGTATAAGCCGTAAGGAGGACCTATGATCGCGATTAAACAAAAATTCATCCCACTAGGGAGTCCGAACCGTCCAGGACGTCGGCGCCAAGCGCGCGGCGTCCTTTTTCATACCACGAATAATTGGAAGTACGGCGCAGGCGATGAGATGCATGGGGAGTACATGGCCACGGTTAAGGATCGGGTCGTCAGCTGGCATGTGACGGTCGATAAGGACAGCGCTACGCAGCATATTCCCTTTGACGAGAATGCCTACCACGCGGGTGACGGTAACGGGGACTACAACTCCTACTGGATCGGGGTAGAGATCGCGTGCGAAGCCGTAGAACCTGGTGAGCCGCTTGATTTGCCAACATACCGCAACGCTGTTGATGTGGTTGCCCAGATCATGATGCAGCAAGGATTCGATTCATGGGAGCAGCTGCAACCCCACAAAGTGGTTTATGGCAAGGATTGCCCGCACCATTCGTTATTGTATCATGACAGGTTCAAAAGAGACGTTTTTGAAAGGATGGGGACAAAATTGCTTCCTGCAGTGGTGAAGGAGCGGATTTATTCTATGAACGGCGTGCTTAAGCGCTGCGATGGAGACTACAAAGTTAAGGCAACAGATGTTCGATACCTGAAACTGGATGGGAAAAGGCTGCGTTTTAAGTTTGTAGCTCGTACAGGGGCAAAGGTATCGGAGCTGCTTATAGAATACGGTGCAGATTTTGCAACGAATGCTCCGTATTTCTGGGACGGCAAAGTGCTTGGAGATGCAGTAGCCGAGGGGCAGGTCATCGCCCAGGCGTACGGCAAGATGCTCACCTGGCATGAGTTCGGGGTTAAGGGAGGCCGGCCGCAAATCGGGCAGCTAGATCCCATAGTGCAATGGGATGTGCTTGTTCAAGGGGCTCCCCTGCTTATCGAGGCCGGAAATATTTGCTGGGATTATTACCGAATTCAACAACAGGTCCCGGATGACATTGGTACAAGCCGGGCACAGCGAACATTGTATGGTATCGATGCATCGGGCGATTTGCATATTGCTGTAGCGGATGGTCGGACGAAGTTCGATCAGGGGCTCACGCTAGAAGAGGCCGCGCTTTACATGCAGTCTAAGGGGATGCACCTGGGCGCTGAACTTCGATGGCGGTGGCTCCAGTGTGCTGGCTCAGAAAGGGAAGGGGAGCCTGGGGCAAAATCAAGGAGCGGGGGAGAGAGTGGTGAATCACGCCCTTCTGATTTGGATTGAAGAACCAGCGCCGATTACACCGCCGGCAGCGTCACCCAGCGAAGAGTGGAAGCAAAAGGCTATTGCATGGCTGACAGAACGCGGAGGCATCGAAAGCCCGCACGACCCAAATGAGCGGGTGGAATTCGCAGAACTCGCTGTAGTACTCAAAAACTTGGTTGAAAAGGGAGCGATTTAATCATGACCATGGAAATCATCCAACCTCATATCACTGAAATTGCCCAGTCCGTTCTTACCATTGCCGCATTGATTGCACTTGCGGGCCTCCGCCAAGTCAAAAAGAAGGCTCTGGAGCTGTACAAAGCACAGACTACTGATGCACAGCGCGAGGTCCTTAATAAAGTCGGCACAGAGGCATTTGCTCACGCCGAAACGCTGTACAAGGGAATGGGCGGGGATGCCAAGCTGGATGCAGCATACGAGTATGCGTCCAAGAAACTCGGGCAACTGGGGGTTAATCTTACTCCCGAGGAGATCAAAGCCTCGATCCATAAAGCGTGGTTGGATCACAATGCGAAGGTGCAACCTGCAAAACTGAATGACTCCGGAACGAGCAGCGACCAAAAGGTGATATAACGAAAGTCCCCCACTGGTTGAGGCGGCCTTCAAGGATTTTGGAGGAGGCGGAGAACTATGTGTTGGGTCGCCTGGAGGACATTGGCTTAACCCTGACCTCACAGGAAGTTCGCGCCGCGATCGAGAAGGCCGTACTGGAGCATAACGCAGTTGTGAAGAATGACACGAAACGCCCTGCCGAAATGCGGGGCGATTTTTTGCTTTACAAACCAAGCCGCTTGAGTCATTATGCCTTGTCTGAACTAACTCTCCCGGTTAGCGTAAACCATTAACATTAACCTGTTGTCTTGCGTGCTTTCTGTTTAAACCATCTCATGCTTATTTTGATTTTTTTTATCTTACTTGATGAGGGTTTCTTCTTAAGTGGAGACGTTATAGTGATTTTGTTGGTTAGGTATCTTGCAGCTGCAGCTATGAAAACAGTCGTAACAAAAGAAGCTGTATAGTGCCAACGATTTATCTCGTACATATCCCAATATACTAACAATGGTTGCGCAATGAAAGATGTTGCAGCAGCAAAAAACATAACACCTGCAAAAAATTTCATTGAGTTGGTGTAATAATAATGAAATAGTAATAAAAGTACTGTAGGGAAGACACTTAGGCTACCCGGTAAAAATGTATGAAATGCAGGGATTATCTTGATTGGATATAAAAATAAATTAAAGCCTAACCCTAATTGATCCAATAGCGAGGCAAGGAATGAAACTAATAAAGTAAAGATCGCATACTCTGCTTTTTTCAGTCTTTGATGACGAAACAAAAGTACTACAATGAGCCATGGAACAATTAGTATGCCCAGCAATAAGTACCATTCCCATGAGAAAATATACTGATTCCAGTAGTCTGTATGAAGATTTTTTAACTTTTCTGAAACAGTTTGGAGTTCACTTTGAAGATTTTTATCCATGATTGGTGCCCCCGCTGTAAGTTCTTCGGTAGTTTTTACGATATATCGTCCCCCTTTGTTGCCTAAATATCCAAATCCAAACCCGATCTTTTCATTTATAACTATCCTGTCCGTTTTGTTGAGTTACCCCCCCATTAGTTTAACAAACTTTGGATTATGCAACACTTGCCATTCGCGTCGTGATCGAGAAGGCCGTACTGGATCATAACGCAGTTGCAAAGAAATAACACGAAGCGCCCTTGCCGATATGGCTGGGCGATTTTTTTGCTTAAAAAACTAGGAATACTAGCTTCGCCGTCTCACATTATTGTTCTTCGCTGAGTTCGACGAAACGGACAACTCTCCTGATCGCTGCACTGAACGGTCGAACCTTCTCGTGGTATGCTCAGGGACTTCAGGGCCAATCAGTCATCAATATCGGATTCCCGAATATACATTTGTGTATTTGGTCCGATCAACTCGTTAGGAAAGGCGTGATCATGTGAATGACAACTGACGGCAATCAAATTGACTATAGTTCTCCTTCATTGAATTTGTCTTTTGACCTAAGGTCTTCTCCGTATTTCATTAAGGACAAACAGAACTTTCTTCTTTATCAAACGGCGAAACAGTTACCCGCCATGCAAGGCCTAAGCTTGGTCGACGTATTTTTAAGTAGAGGACATAGCGTAGAACCTCATTGGCACCCCAATGCGAATGAACTACTTTATATGATACAAGGAGAGATCGTCGAATCCGTTCTGAATCCATTCACTCTTCAAGTGCTTAGTTACCGTGTAGGGCCACTACAATCGGTGTATATCCCGATGGGATGGTGGCATTGGACGATCGCAGTCACAGATCACACCCGCCTTGTGGTCAGCTTCGATAATGGACAATTTGAAACCACTTATGGATCTGACATCCTGAGGAAGACGCCTCCTGAGGTGATCCAGATAGTATACGGCATAAAAGCAGCCCAATGGGCTGAAGTAATCAAGCCGATCGATCAAACCGTTGTCATTGGTCCGCCGCGAGGCACGATGACGAATAGGAACCAAAGGTCACCATAAGGGTGACCTCTTTTTTATTCAAGCGGAAGTAAAGCGTATGAACAACAACGGTTGCTGGAAACAATAGGGATTACGACTTTTTGAAAGTAGGAGAATTTATGCCGAACATGATCTGGTATTACGGATTGATTGTCATAGGGGCGATCATTACAGGCTATACGTTGTTTCGAAAAAGAAATGTAGTGGATTTGTTCACTTACTTTTTGTTTACAACAGCTTGGACATGGGTAGGTGAAGCCGTCGTGCTCTTCGTATTCAATGCTTACGCTTATAAACCCGGACTGTATCCGGATCCTTTTGCTGAAAATATTATCGGCCATATCATAGCAAATTCAGCAATATGGGCGTCAACCGCGATTTGGGTTATGATTTTTCAGCCGACCTATCTCATTATCGGATTGATCTGCTTATTGTTTATGCTGATAGAGGAAATGTTTCTTAACGCCGGCGTCTATACTCAGTATTGGTGGCACACATATATGACCGGTATTTGTTCCTTTGTTTTTTTAGCTGCCATGAAGAAGTGGTACATAATATTAAAGAAAACTAAACGAAACTCCCCACGCATTACAGTTTTCTGGACAATCGCATGGATCATTTTACAGACTCCGACGAGCGTGCTCATGCTTTTCGACAAACAGTTTTTTCGCGTAAATTGGGTCGAGAACATTTACAGGGACAGCACGTTATTTAGCGGTTTTTTGTACCATGTCCTGATGGCATTTATTGTAATCTACTTTATGTTCGTGCCCAAGAACAAATACTGGAAACTGGCCCCTTTCTTAATTCTGATATTAGCAGATGTAATTCTCTGGAGCACCGGCATATTGATATTCTATGGTGATTGGAAAATGATTTATCTAATCTGCATTCGCGCCGCATGTTTGCTGTACATCTACATGCTTGAGAAACATTCGGTAAACAGCGTGATTGAGAAGGCATCGCTGGAGCATAAAGCTGTTGCGAAGAAATGACTTTAAGCGCCCTTGCCGAATGGCAGGGCGCTGTTTGCTATCATACCCTCCTCTCACCGTCATGGATGAATAATAATTTGTCAGGATGTAACAATACCAAGTGAGGCAGTGAGAGGGGGAGTCCGGTGGGGTTTGCTTTTTTCTTTTTTGTGGCGTGGCTTACGATAGCAGGATTCGGGTTTATGAGGAAGCAGCTTACTTTTGTCGAAAATACCGTTCTGCTGTTACTCATCATGATTATCAGCATTCACTGGTCGTGGATTATCTTTGAAGAGTTGAAGCACGTCGAGATTTCAAAAGAACCAATAAATTATACGACCTTCCTGATCCACCGGAGCATTACCATCCCTGTGATGGTGGTCATCGCTATCAATTTGGTGAAGCGGGCGGCTACCATTACCAAAGCACTGCTGACGGCCGGCCTTTCCGTCCTGCTTCATGTGGTCCTTGTACTTGTCGGACGTTTTGTCGGGATCACGCATGCGGTGCATTGGAATCTGATCTATGACGTGGTTTATTTTGCTCTGCTGCACGTCATCGCTTATGTCTTCTTAAAGTACTTCCACCATTTGGGCCAAAGCGAGGCGGAACGCGTATGACTCTCTGGGTGAACTTCAGTCTCAACGAAATCTCGATATTGGTGCTCAACACCGCCGTGTATGTGCTCATGTTTTTTCTGCCCAGGAAATTAACGTCTCAGGTCCGAACGCTGAGCTTGCTATGGGGATTCACCATTGGGGTTATCTTTGATTTTACGATCGGCGGAGGACTCATTGATTTCTATATGGTGAACGATTCGAACCATTTTGAAGCCTTTGATTTTTTGTATTACTTTCTGTTTGCGCCCTTCGGATATTTTTTCTTCTATTTCTATGAAATCCTGCGGATCAACAAAAAAACGTTCATTCCTTATGTGTTGGCCTGGTCCGTCGTTGGGGTGGCGGCGCAGTGGGCGTTCACCTTTCTGGAGATTATTACGTTTCAGAAAGGGTACAAGGTCCCTTATTCGTTCCCAGTGTTCCTGGTAACCCAGACCTTGACGGGGATATATTTGGAACGCGTAAAGTCCAGACAACCTATTATGGCTGCTCCCAAGAAGAAAGAGTCCAGAAAATATGTGCTCAGGAGATGGCTTACCTGAGAAGAAAGCTATGGGAAATAAGCCCACCTGCCGATATAGTTTATGGAGGTGGACTTTATGAGAAAAGTGGAACGCAATGCTCTCCAGCCTGGCAGACTGATAAACGTGTATTACGATTTAGGAGGAGGTGAGGAAATGAGTGTCGGGCATTTTAGAGAAATCAGCATCGACATTCTTGATGAAGATTCTTCGGCTTTCATAATACTAGAAGGCATAAATGAGGGAATTATGGGAATCAATCTGGAATGTGTATAAAATGTTATTCCAGCTTGATAAAAACTAAACTGTTCGCATATAATGCGAACAGAGGTGATTTACGGATGCTGCAGGGTATTGAGCGTAAAGTTTTACGGATCATAGCGAATTATTGGAGTGGCCGACACCGCTGTCCTTTGATTGATGAGCTGATGATCAAGACCGGTCGCAGTAAAGAGGGCATATACAAAGTACTAACGGTGCTCGCGAAAGAGGAGTACATCGAGTGGTCCCCTACAATCCCCCAAGTTATGTTAGTCATCAATCCGTATGAACGAGATGCGCCGAACAACTGGGCGCAACCGGTCCGATCCCAAACTAGGTACTTCATGGATTAGTCCAAAGTTACCTTTGACCATGATGCATTACTAAGAGGATACCGGTTACATGACACCTTTTATAAGGGTGACAGCTAGTACATACAAAGTAGCCGCGGGCTTACCGTGGCTTTTCCCTTATCCAAAATTATTCGAAATGGAGCTAATTTTTTGTGCCTTTCATTTCAAAACGACGGTATTTGAGACAAGTTTTTTTGTCAGATGACCTGATACTGGAGCTACAGCAATGGATAAAGAGATAATGGGCCAGTATTGGGTAAGCAAGAACATCGCCCGGAGATGGTCCTTAACTACCCAATACCCGAATCCGGCCATTACCGCCCAACAGGCACCAGCAGGGGACGGTAATCCGGGAGGCCAACGATTATAGAGGCTGCCAGCGATCCGCAGAATAGACAAACTATACATTGAACAAGAGCGGAGATAGCCAAGAAGTCAAAATAAAATGTCCGATATGCGCGCTTCTGGCCATCTGCATACAGGCTGCAATTGTTCCGTGACTGCTGGGGAACGGATCCCAACCTCCATCACTGGCCACATGATGACAAAGAATCCCCCCACCAGTAGGCTAGTTACTCCTCTTCTCGAGAGGCTTTTTTGGTGCAAAACTTCTGTCTTTCTTTATATCAAGACTTCATAATATGCCATGGCCCTCCGAAACAACTCATCCGTATGCATATCGAAGCCCGTCCCGACCGGGTCTGAAATAAGATTACACAAGGATGCAGGTTCCCAAGCATCTTCGTTCTCCCGCCATTGCGCCTCAATCGCATCGGATAGCAGCTTCAAGGCGGAGCAAGCAGGTCCGATCAGGTAGTCCTTGTGAATTTCGAGCGAATAACCTTGTAACCAGAGATGGTTCGCGTAAGTGATCATTTCCGTCACTGTGCCTCTGTCGCCAGGGTGAATATGCCGGACGCTATTCCTTTTGCCATAACGATTTGCCCAGGCGTCCCTGACAGGTTCCGGTCTTGCGCGCAGCATAATATGTGACGCTATGGATACGTTTTGCCTACGCGCGACGAGATCCAGAAGAGCGGTTTGAACCAGATCCGTTCGGTTGTCGCCCCATATGATCCGATGCAAAGCCGTGATTTCGAGAGCTTTGCGAATGGTTGTTCGCTTCAACTGATGGAGGAAAGAGGCCCATCTGATTATATCGAACGCCTTGTCGTCGGAAGACATGATACATTCACCCCATCCGGAGTAGGAGCCGCAGCTGATGAGCAGCACCCCGTAGCGGCAATTCGTCAGCCTTCCCTTCCTCGCATGGAAACAGGACTCATAATCAAGCTCGAAAAGCTGGATCCCCGTAATACGTGCATCTTCCAAACGCTTGTCTTCTTCGCTAATAACGAGAGCGTCGTTTATTAAGCCAATTGTCATCGTCATCTCTGCGTCACCTCAACCAGAAGGATAACGGCGATACCCAGGCGATAAAACAGAGTATTCCGCAATTCCTTTCTTAACCGCTGCCTCTCCTCTCGATATGGAGGTTGAATCGAGTTACCGTTGTTCATGATGATTTCCCTTCCTTTCGGATCGTAATGGTCCGATTGAGCAGGGCACAGCATAGAAGCCGTACTTAAGAAGGAGATCCGCTTCAGTAGGGCTTATCGTTCATGGACGTCTCGTCCTATAAGCGCATAGAAGATAGGTCTCTCTGAACGCTTACGAGGTTAGCTGTCGGATTCGGACTGAGAGTAGCCCTTCATGAAAGAAATCATGATTCACCCCAAGGCAGTTGTCAGCCAACTCTAGGTTCCCCCGTTTCCCGGATCCGGGAATTCAGCGATTACGGCATTTCAGCGTATACCTTACCATTCGAACTGAGCAACATGATACGCGATGATGGCATGTACTGTAAAATTCGCGAAATGCGATATAACGATGAAATATCGAAAATTAGCTTGTCATCCCTGATTTCGAGCGATAGAAGCCAGTGTTTCGCGATTGCAGCCTATGCTGTCTCGCTCAATCGTGCAAAAGGGACGATAAGCCTCGGAAGATGAACGATAACCCGCATTCGCCGATTATGGAAACGAATGCGGGCCGATATTTTTTTATACTTTTTTTACGCGTCCCCGCGACATCTTAACACTATTTTTATGCCGAACCGTATTATCATTGCTTATGCGGAAGCAGAAAAACAAAATATGAACCGCTGAATTTCACGACACGTGGAAGCGGGGGAACCACTGGGACCGGACCGTAAGCCGGACTATGGGGTGAATCCCAAGGTAACTTGGGTAAGGCGACTCTCACGCCCGAATCCGACAGCTAACCTCGTAAGCGAATCTAGGGAGCAACATTTTTTCGTAATGCGCGCGTTTATTTGGCTGCGAGCGCAGAAGCAGCGAGAAGAGTCAATCTTCCGCGGCTTCTTTTTTGTTGCTCTTACGGTGGAGGAGAAGGTGCAATGAGTTTAAAAACGGACGGGTCTTACATCTTGGTGGCCACCACGAACAAGAGAGGAAGGGCATTTATGAGCGTGCTCCATTCGATGAACATGCCGTACGCCGTGCTAACAAACAGCAAGCAGGAAATGCTGGAGCTGGAGGAGCTCGGGATCGAACCTACCGTTCTAGTCGATACCGTCGATAGGTCAGCCTGGTTGGTACCGGATATTCCTATTGGCAAGGTGATTATCTTTGAAGAGTCTCTGCCGCTAACCTGCCGCTATCTGCAGGCTGTCACATCTTGGACCCAAGGTCCCATCTATGTGGTATCAAGCAGTGGGATGATTCGAAGGATGTATAAGGAACTGGGAGCCACATACGTCATTCATAGCCGAAATGCTGATGTGTCGTTTTTACTCGATATAAGTTCGAAATAGGAGGTTAGGTTACCATGTTGGATATTGTGATGGTGGTATCTTTTATTGTTCTGGCTTTACTAATGGCGGGATTGGCTGCTTGGGCTGGCAAAGTTTCCGATGAAGGAGCTGGCCGTTCATGATGTGGGCGCTTGGTGTAGTAGTTGTCGCCGTCTTTGTCTATCTGACATATGTGTTGTTAAATCCAGAAAAATTCTAACTGCGGGAAGATAGGAAGGGGTTTGGGTCGTTATGTACGCTACTTTGTCCATCGTGGTTACGCTGCTGCTTGTCTTGGTGCTGGCGCGGCCAGTCGGTCTTTATATGGCACAGGTTTTTGATTATGAGAAGTCCAAATGGGACAAATGGTTCGGCTGGATCGAGAAGCCGATCTATACCATTAGCGGGATCTGCCGCGACAATCAGACCTGGAAGCAATATGCGCTCGCTGTCGTCTTTAGCAATCTGGTCATGATCATTCTGGTTTATTTGATTTTTCGTTTTCAGAAGTTTCTGCCGCTCAATCCATCCGGAATTGCGAATATGGAGCCCACGCTGGCATTCAACACGGCGATCAGCTTCATGACCAATACGAATTTGCAGCATTACAGCGGAGAAAGCGGCCTTTCCTATCTATCTCAAATGATTGCTATCGTATTCATGATGTTTACGGCTCCTGCTACGGGACTAGCGGCAGCGATTGCCATCATTAGGGCGCTTGCGGGTAAGCCGATAGGCAATTTCTTTGTCGATTTGATTCGTTCGATTACACGAATTTTGCTCCCTGTAGCTTTTGTCGCGGCACTGATCTTTATTGCGCTTGGTGTACCGCAAACACTTGAACCTACCGTTACGGCTCATACGATCGGCGGTGAAGTGCAGGAGATTGCACGCGGTCCGGTGGGATCGTTCCTCTCCATTAAGGAGCTTGGCAATAATGGCGGCGGCTTCTTCGGCGCAAATTCCGCCCATCCGTTCGAAAACCCGGATGCGATCAGCAATCTGCTGCAAATCGTTCTGATGCTGCTTTTTGGCACGGCAATTCCTTTTACGTATGGCAAAATGGTCGGTAATGCAAAACAAGGGCGTGTACTATTCGTATCCATGGCGATGCTCTTCATTATGATGCTGGGGATATCGCTGGTGGCTGAGACGGCCGGCAACCCCGTCTTGAATGCCAGCGGAATTCAGCATGATCAAGGCAGCATGGAAGGGAAAGAAACGCGATTTGGCGTGATTCAATCGTCTTTCTATTCGGTTGTGACGACCGCTTCGGAGACAGGCGCCGTGAATACGATGCATGACACGATGACACCGATCGGCGGACTTGTCACGCTCGCGAATATGATGCTTAATACCGTATTCGGAGGTGCCGGAGTTGGCTTTATCAACGTTCTCATGTATACGATTATTGGTGTTTTCTTATCGGGCTTAATGGTGGGGCGGACACCGGAGTTCCTCGGCAAGAAGATCGAGGGTCGGGAGATGAAGCTGATTGCCGTTACTTTGCTGATCCAGCCGTTCATAATATTAGCACCGACGGCGCTTGCACTTTTCATCTATCCGGAGACGATCTCTAATCCTGGATTTCACGGGCTAACACAGGCTCTATACGAATTTACCTCCTCTGCGGCCAATAACGGCTCCGGCTTCGAGGGACTTGGCGACAATACGCCATTTTGGAATATCTCAACAGGCATAGTGATGTACCTGGGGCGTTTCTTCTCGATCGTGACCATGCTGGCGGTTGCAGGCTCGTTGGCAGCCAAGAAGCCGGTGCCGGAAACCTCGGGTACATTCCGTACCGACAACGGATTATTCGCCGGCGTATTCCTTGGGACGGTTCTAATTGTAGGCGCGCTTACCTTCTTCCCGGCCCTTGTGCTCGGACCGATTGCAGAACAATTAACGCTTAAGCCATAAGCATAGAAAGTAAAAGCGGAGGAACTTAGCCATGAGAGAGAAAAAATCGATGATGAGCAGCGCGATTATTCAGAAAGCGGTCAAGGAGTCATTTCTGAAACTAGATCCGCGTGTCATGGTTCGGAACCCGATCATGTTCATTGTAGAGATCGGTTTTCTAATTACAATGCTGCTGATTTTCGTGCCGGATTTATTCGGCGGTACCGTTTCAAGAGGCTACAACCTGGTCGTGTCACTGATTTTGCTGTTCACCGTATTGTTTGCGAACTTTGCTGAAGCATTGGCAGAAGGTCGGGGAAAGGCGCAGGCTGACACGCTAAAGAAAACGAAGCAGGATATCAAGGCGAATAAAATCGTCGGACACCATTCCATCAAGCAGGTAGTATCGTCGGAGCTTCGCAAAGGCGATGTCGTTATTGTCACGCAAGGAGAGATGATTCCCGGCGACGGCGAAGTGATCGAGGGACTTGCATCGGTTGATGAATCCGCGATTACAGGCGAGTCGGCTCCTGTTATTAAGGAGGCCGGCGGCGATTTCAGTTCGGTCACCGGAGGTACGCGTGTCGTCAGCGACCAGATTAAGGTGCGGATTACGAGCGACCCGGGGGAATCGTTCCTTGATCGTATGATCGCGCTCGTTGAAGGCGCCAAAAGGCAGAAAACTCCCAACGAAATTGCGCTTAGTACCGTTTTGACAAGCTTGACCTTAATCTTTTTCATTGTTGTCGTGACGCTTCCATTCTTCGGGAACTACTTGAACGTCAATTTGGAAATACCGATGCTGATCGCGCTTCTCGTCTGTTTGATTCCGACGACAATTGGCGGTCTGCTGTCGGCGATTGGTATTGCCGGCATGGACCGCGTAACACAGTTCAATGTGCTTGCGATGTCCGGAAAAGCGGTAGAGGCAGCAGGGGATATCAATACGATTATTCTCGATAAGACGGGCACAATCACGTTCGGCAATCGGATGGCGAGCGAATTCATTCCCGTCGGGGGACATCAGGAGAAGGAAACGGCTGCGTGGGCGGCAATCAGCTCGCTTCAGGACGAGACGCCCGAGGGGCGTTCCGTACTAGAACTGATGAAGAAGCAAGGGTTCACACATGACGCCGCTGTAGGAGACGGGGCCGAATTTCTCGAATTCAAGGCTGAAACCCGGATGAGCGGCATGGATCTGAAGGATGGCCGCAAGGTGCGCAAAGGCGCCGTCGATGCCGTCAAAAAGTGGATTGTTGCCCAAGGCGGTAAAATCCCGAAGGACCTTGATCCAAGCAGCGACCGAATTGCCAAAGCCGGCGGCACGCCGCTTGCCGTGGCCGTCGATCAAGAGATTTTTGGCCTGATCTACTTGAAGGATACCGTCAAACCGGGCATGAAGGAACGTTTTGAACAAATGCGCCGGATGGGGATTAAAACGATCATGTGTACGGGTGATAACCCGTTGACGGCAGCAACAATCGCGATCGAGGCCGGCGTAGATGATTTTATCGCCGAGAGCAAGCCGGAAGATAAGATTGCAGTCATTCGCAAAGAGCAGGCGGAAGGCAAGCTAGTTGCGATGACGGGCGATGGTACCAATGACGCGCCTGCGTTGGCGCAGGCCGATGTAGGCATAGCGATGAACAGCGGAACGGTAGCTGCCAAAGAAGCGGCTAATATGGTCGATCTGGACTCGGACCCATCTAAAATCATTGAAGTCGTGGCGATTGGCAAACAGCTGCTGATGACGCGCGGCGCATTGACGACATTCAGTATTGCGAACGATATCGCTAAATATTTTGCGATCATCCCTGCAATGTTCATGCTGGCCATCCCGCAGATGGACGCCTTGAATATTATGCGGCTAGGTTCGCCGAATTCCGCGATCTTGTCAGCTTTGATCTTCAATGCTGTCATCATTCCCTTGTTAATTCCGCTGGCGATGAAAGGGGTAGCGTATAAGCCCATGTCTTCGTCCGCGCTGCTGCAGCGCAATCTGTTCTTTTACGGTTTGGGCGGCGTAATCGTGCCGTTCCTAGGCATTAAATTGATCGATCTTGTCGTTCATCTGTGGGTATAACGGGAAAGGAAGGAAACCAATGAAATTGATTGTGAGCAGTATTCGATTAAGTCTCGTGCTTATGGTGGTATGCGGACTTCTTTATAATCTTGTCGTGACGGGCATTGCGCAAGCGGTTATGCCCCATCAGGCAGACGGAAGCTTGGTCTACGATGAAAACCAGAACGTTATCGGGTCGGAATTGATTGGACAACACTTTGTCGATCCGAAATATTTCCAGAGCCGCGTATCTTCCATTGGATATAATGGAGCTGGCTCAGGGAGCGGCAACTATGCCCCGTCCCATCCAGATCTGCTAGCGCGTGTTCAGAAGTCGCTCGAGTCGTGGAAGAAAGAAAATCCCGATGTGCCGGTTAGCCGTCTGCCGATCGATCTGATCACAAACTCGGGTTCCGGGCTGGATCCTCACATCAGTCCTGAAGCGGCCGAGGCGCAAATCCCGAGAATAAGCAAGCTGACGGGAATTTCTGCAGAGAAGCTCCAGGAATTGGTGAAGGACCATACAGCTGCAAGAGAGCTAGGATTCCTTGGCGAGCCGGTGGTCCTTGTGCTGCAGTTAAATCTGGCTTTGGCCGAGCTTACGAAATAAATACAACCCCGCTAAAGTGTACGACTTTAGCGGGGTAATTGACTTTTTAGCAGGCAACGCTAAACCCGTATAACAGGAGGATTCCATGGACGAATTCAGAAGGAAAACCCCTGAGGAAATCTTAAAGTCGATCTCTGAGCTGCAGCGAGGCCGGCTCAAGATTTATGTCGGCCCGTTCAGCGGCTCGGGCAAAACCTATCATATGCTGCAAGAGGGCAACAGTCTCAAACAACGGGGGATCGATGTCGTGATTTGTGCGGTATCTACCATGCAGCGGAAAGAGACGATCGAGCAGATCGGGTGTTTGGAAAGGGTGCCGAGTATTCATTGGGTAAAGGACGGCGTAGAGAAGAAGGACCTGAACATAGAAGCGCTGCTCGCGCGCAACCCGGAAGTGGTTCTGGTCGATGGTCTTGCTCACCGTAATCGCATGGAGGCGAGGTTTAGAACGCGCCTCCAGGATATTCAGCATTTGTTAAAGCAAGGCATCAGTGTCATCACGACGGTCAATGTTTACGAGTTGGAAGGGTATACGGAACTGGCCCAGAGGCTGACCGGGATCGAAGTGGATGAAACAGTTCCAGCCGACACCTTGGAGCTGGCTGATGAAATTCGGCTTATCGACGTAACGCCGGAGTCCATACTCGCACGTCTCTCAGAAGGTGCAATGGAGGCCACCCACACCTCGCTTAGTAAAAGAGATAACCTCGGCAAACTTCGGGAACTCGCGCTGCGTCTCGTTGCCGAGGATGTGAACGAATCGCTCGAAGAGCACCGGGAGGCGCTTGGATTAAACGGTCCCTCGGGGGCTTCAGAACGTATATTGGTGTCGACGCAATACCATTGGAATGGATCCATTTATATACGACGCGGTGAGCAAATTGCCAGACGGTTAAATGGGGATATGCTGGTCGTTACGTTCGTAGATCCGAAGAAACCGTTATCGAAGGAGCAAACCGCTTTCAAACGCTCGATCGTCAAGTTGACCGAGAAGCTGGAAGTCTCCTTCGACGAACTCCCCTTCGTGCGCCGCAGAGCGATGCCAAGACAGCTCGTGGACTATGCGATCGACAATAAAGTGACGCGGATCGTACTCGGTCACTCGAAGCAGACAACTTGGCAGGAATGGTGGAGAGGATCGGTGGTCAATACGCTTATGAAGCTTGCTCGCCATGTGGATTTGTTTTATATGGCCGATTCAGCCGAGCAGAAAGGTGAGCGAATCCTACCTACTTCGATCACAAAGAAAGCAGACGCAAATATATACAAACGATTGAGCGGCTCCGAGGTGAAGGAGCGAATCATCCGCATCAAGCGAGGGACATTTAAGATCTATATCGGAGCTGCGCCGGGCGTAGGGAAAACGTACACGATGCTCAAGGAAGGGAACATTCTGCTTAAGAAAGGGATCGATGTGGTCATTGGACTGCTGGAGACGCATGGACGTAAAGAGACGTTCGAGCAGATTGGAGACCTGACTACGATACCAAGGCAAGTTAGCGATTACCGGGGAACCCGATTGGAAGAAATGAATATGGAAGCCATTATCCGCCTAAACCCCGAGGTTGTTCTTGTGGATGAGCTTGCGCATACCAACGTGCCCGGCAGTAAGAATAAGAAACGTTATGAAGATATTCTCGAAATTCTGGAAGCGGGTATTTCCGTTATTTCCACGATGAATGTGCAGCATGTCGAAAGCTTGAATGATGCGGTTGAGCAGCTGACAGGCGTAAGAGTAAGGGAAACCGTGCCGGACCGTATTCTCCGCTTGGCCGATGAAGTGCAATTAATCGATGTCGCCCCCAATGCCTTGCAACAGCGGCTGCGCGACGGGAAGATCTATGCGCGTAATAAAGTAGAGCAAGCGTTGAATCATTTTTTCAAGACAGGCAATCTGATTGCGCTTCGTGAGCTTGCCCTGCGTGAGATTGCCGATGACGTGGATGAACGACTTGAGGCATGGGAGCGGCGGGATTCCCTCAGAGGACCCTGGAGGCGTGAAGAGGTTATTTTCGTCTGTGTTACCTTGAGCCCGCGGGCGGAAAGCCTGATCCGCAGAGGCTTCCGAATCGCCCATCGCTTGAAAGCCGATTGGGTTGTCCATTATATTGCCGTGAAAGCAGATTTGCCTGAAGAGCAGCAGAAACGGATTATGGATCTTCGGGAGCTAACGCAGCGCCTCGGTGGAATATTCAACATGCAGGTTATGGAGAGACGCAGACAAGTAGCGGTTAAGCTTCTGGAGCAAGCGAATGTGAACAAAAGCACACAATTGATCATCGGACAATCCCAGATGAAGTTTTGGGAGCGGATGCTATATGGGAATACGGTCAAAACGATCCTTAAATACGGACGGCACATGGATGTGCTAGTCGTCTCAGGGTTCGTCCCGAAAGAAAGATGACCGTTGCTTGCCTTCTCCATCCAGTCTGTCATACTGAATATAAGCAGCAAGCAATCCTTCGTAGGATGTGATTTTACATGATACAACAACGCTCTTATCTATGGGTTACCTTATCGATTATCCTACTAACCTTTGTGCTGAATATGCTCGGACCGGCATTCGATTTGGTCAATATCGCGCTTGTTTATTTGCTGCCGGTGTTAATTAGTGCGGTCTATGGAGGAAAAGGAGCTTCGTTTTATGCGGCGGTTCTGGGCGTGCTGGCCTTTGACTTTTTCTTTGTCCCACCGCAGCTGAGCTTCTCCGTATCAGATCTTCGCTATGTGGTTTCCTTTGGCATATTCCTGTTTGTAGCCTCGTTAACGGGGGGGCTCGCCGCCAAGCTGAAAAATCAACTGCACTATTCGAAGCAGCGGGAGGCCTACACCGCATCGTTGTATGCATTAAGCAAAGAAATGAATGCGATCGCCGATTTTCAAGCCTTGCTTCAACATATCACCTTAAAGGTGTCGCATACCGTACAATCCGAGTCGGTGATCTATTTACCGAATGAAAGGGATGAATTGGAGCCCGCTTCTTATTCAATGCCAGTGCCCGCATGGGCGCAAAGCGAAGCGGAAATGGTGATTGCCAAATGGGTTTACCAGCATGGCGAGCATGCGGGCAAGGGAGCCGGGACATTGCGAGAAGCCTCGGGGCGCTATATCCCGCTGAAGATCGAAGAGAAAATTTACGGCGTCTTGAGCGTTAATCTGGGAAGCTCGGCTCCTTCATCGGATATGTTAAAATTGCTGGAAGCGTTAGGCGAGATCGCCGCTAGTGCGATTGCGCGCGTCAAACTAAGCGAAGAAGCAAAGCTTGCGCACTTGACAGCGGAGTCGGAGAGACTTCGAACGGCTATACTGGATTCTGTTTCCCATGAACTACGGACGCCGCTCGCAACGGTCATTGGCTCTGCGACGGCGTTAATTGAAGGGGAGGGTATGTTCTCCCCGCAAGACAGAATGGAGCTGCTCGTAACGATTCGTGACGGATCGTTGCGGATGAATCGTCTAGTGTCCAACCTGCTCGGTATGGTGCAGCTCGAGAGCGGCATGCTCCGTCTGCGCAAAAGATGGTGCGATGTAGAGGATATCATCGGCGTCGCGCTCAAGCAGGTGAAGGATTTTCAACAGCATCGCAAAATACGCGTACAATTCTTGAAGCAGGTTCCGCTGATCTTAGGTGACGAGGTACTGCTCGAGCAGGTATTGGTGAATATCATTAGCAATGCGATTAAATATTCACCTGATGGCAGTGAAATTAACATTATGGTCAATAAAGAGGAGGACGCGGTCTTCTTCTCCGTATCTGATCAAGGGATTGGTATAGAAGTATCGGAGCGGGAACGTATATTCGATAAATTTTATCGCGCAGACAAGTCGAAGCATATAACCGGAACTGGCTTGGGACTTGCCATTTGCAAAGGAATTGTCGAACTGCATGGAGGAACAATCTCGGCTAAACCGAACGGGGAAAAAGGGTTGTCAATCGTGATCAGTTTGCCAATTAGTGATGAGGATAAGATATTTTTTATACATGAAGAGGGGGAACAGGCGCCAGTATGACGACCACAGAGAAAGGGACGAGGATTCTTATCATCGATGACGAGCCCCAAATTCGAAAGCTGCTTAAAGTGACGCTGCAAGCACACAACTATCAGGTTGAAGGGTCGGAGACCGGCGAAGATGGGATCATTAAGGCCTCCGGAGCGCCTCCCGATTTGATCCTGCTGGACTTGGGGCTTCCCGGGTTGTCTGGCATGGAGGTTCTAAACCGGATACGGGAATGGTCGAGTGTACCTGTTATTGTACTTACGGCCAAGGATCGGGAAGAAGATAAAATTGCAGCGTTGGATGGAGGCGCGGATGATTATGTCACGAAGCCGTTCAGCATGGGTGAACTGGTTGCACGGATACGTGTTGCGCTTCGCCATGCAGCAAAAACGGTTCATGAACCCGTCTTGAAGTTTAACGAGCTGATCATAGACTTATCGCAAAGGAACGTTGTACTTGGAGGTGAGCGGGTCAAGCTGACACCTACGGAATACGATCTGCTCAAAATATTAGCGACTAACGCCGACAAGGTTATCACGCAGCGGCAGCTGCTGCAGCAAGTTTGGGGCGGGCACCACAGTGAATCCGAAAGTCACTACCTAAGGGTATATATTAGCCATTTAAGGAAGAAACTCGAGGAGGACCCAACTCGGCCAAAGATGATTGTGACGGAATCCGGGATTGGATATCGATTTGTTACACCTGAGTGACAGATAATATTACCAAGGGTCCAGGATTCATCTCGAGGAAAGACATTGATGCATTTTTTACGGCAAGATCCGCGACATGCGTAACCGGGCTCGTCACTCGGGACAGCCCTTTGGTCTGTCCCGGGGCAGATCATTATTGCGTGTATGATCCAAGTTGGCGGACTAGGATTCATGACCATGTCTACTCTATTCATTTGGTCGCGGTAATCGCGGCCTTTTTGATTTATGGGATAAAGAAGTGCCGGACAAGTTGAGAAACAAACGCTTTGACAAACCAGCTACTGCGTGATACTATGTAGAAGTAGTAAGTAACACTGCATACCAGTCTTACAGAATAGCGAAGGGTGATTGTGCTGGAAAACTTAACGGAAATGCTCAAAGGCGTGCTTGAGGGCTGCGTACTCGAAATTATAAGCCGCAAAGAAACCTACGGCTACGAAATTACGCGGCGGCTGAACGCCCTCGGCTTCACTGATGTTGTGGAGGGAACGGTGTACACCATCCTGATTCGGCTTGAAAAAAGCAAGTTGGTAGAAGTAACCAAAAAGCCCTCCGACATGGGGCCGCCGCGAAAGTTTTTCGCGCTCAACGACGCGGGGCGTGAGGAGCTGCAAAGGTTCTGGGGAAAATGGGAGTTCGTATCATCCAAAATGAACGAGTTAAAGGAGATGAAATCATGAATTTTTGGGAAAAAATCACCGGCAGCGACATGACGAAAGAAATGAAAACTTTTGAATCGCGAGCCAAAAAGCTCCCGGCTGATTATCAAACGGCATGGAAACAAATTAATGCCAACCTTTGGCCGCACTCCGATTTCACCGGTCGAAACCTCATGCCAATTCTTGATGGCGTGCTCGGTCTTCTCGAAGAAACGGCGGCTGACGGTCAGCGAGTCCAAGAGGTTTTGGGCGACGATATCAAAGGCTTCTGTTCGGCGCTGGCCGGCGAAGAAGGGGCAAAGGTCTTATCGCGACAAGTGGCGCGAGCAGCTCAACAATAATATTGCAAAAAAAATAGGTAAAAAATAGGAGGGGAATTATGAAAATACACGATATCATCCAAGGCAAAAAAGAGTGGCGAGCGCATGTGGCGCGTGTCAAAGCGCTTCCGCAAGATTATCAGATCGTTTATAAAGAAATTCAAAAATATTTCTTTAAGGTCGGCCCTGTCGAGCTAACCGAAGGGACGGGTTTGCTCTCGGGAATCGTCGATCTTTTTGAAGAGGGAGCGGCCTCGGGGAAAGGCGTGCTCGAAGTGACGGGCAGAGACGTAGCGGCATTTTGCGACGATCTCATCAAAGATTCAAAAACTTACGCTGACATTTATCAACAATCTATTGATCAAAAGGGTAACAAGAAATGAAATAGGCCGCGGATAAAAAATAATGGAGGGGATATCGGGATGGGAAAAGCGATTGAAGTGAAAGGTCTGCAAAAGTCCTACAAGAAACTTCATGTTCTAAAGGGCGTCGATTTTGAGGTAGAAAAGGGCAGCATTTTCGCCCTGCTCGGCTCCAACGGGGCCGGCAAGACAACGGTTGTCAAAATTCTCAGTACACTGCTCCAACCGGACAGCGGAACCGTCACCGTTAATGGATTTGATATTGCGTCAAAGCCAGACCCAGTACGACAGTCGATTAGTTTGACCGGGCAATTTGCCGCGGTTGACGAGATTTTGACCGGGCGGGAGAATCTTATTTTAATCGCCAAGCTACGGCACCTTAAAAATCCGCGGCAGGTTGCGGACGATATGCTTAAGCGCTTCGGCTTGACAGATGCCGCGAACCGAAAGGCATCTACTTATTCGGGGGGGATGCGCCGCAGGCTCGACATCGCCTTGAGCCTTGTGGGGAAACCGCAAATCATTTTCCTCGACGAGCCGACCACCGGGCTTGACCCCGAGGCACGCATCGAGGTTTGGAAAATTGTCAAGGAACTGGCGGACGGCGGCACGACGGTATTCCTGACCACACAGTATTTGGAGGAAGCCGAGCAGCTTGCCGACCGAATTTCCATTCTGCACGAGGGCAGAATTATCGCCAGCGGCACGCTTGCGGAATTGAAAAAGCTGTTCCCGAAAACGCAGGTAGAGTATGTTGAAAAACAGCCGACATTAGAGGAAATATTCCTCGCCATCATCGGTAAAAAGGAGGCCATCTAATGGAGGTGGCAAAAAACCATTTTTTCAGTGACTTGAGCGTCATGCTTGGACGTTCCATGCGCCATATTTTCCGCAGTATGGACACCATCTTCACGGTCTGCATCACTCCGATTGCCATGATGCTGCTGTTCGTCTATGTGTTTGGCGGCGCAATCCAAACCGGTACGGATAACTATGTGAACTACCTGTTGCCAGGCATACTGCTAATGGCTATTGCCAGCGGGGTGGCCTACGTGGCTTACCGCCTATTTTTGGATAAGCAACGGGGCATCATTGAGCGGTTCCACTCCATGCCGATTGCGCGTTCCACTGTGCTGTGGGGGCATGTGCTGACATCGGTGGTATCCAACGTCATTTCTGTTGTCGTCATCATTCTCGTAGCGCTCATTATGGGATTCCGTTCGTCGGCAGGGGTACTGTCTTGGCTTGCCGTAGCCGGTATACTCGTGTTGTTTACGCTGGCTTTGACTTGGGTCGCGGTCATTGCCGGACTGTCAGCAAAAACAGTGGAAGGTGCAAGTGCCTTTTCCTATCCGTTGATCTTCCTGCCGTTTATCAGCTCAGCGTTCGTGCCGACCGAGACGATGCCATTAGTCGTACGCGCCTTTGCCGAAAACCAGCCTGTGACGTCTATCGTAGAAACCATCCGTGCGTTACTGTCAAATTCACCGGTAGGCAATGATATCTGGGTCGCTTTAGCGTGGTGCTTAGGGATAATCATCATCGCATATCTATTTGCGGTGCGCGCATACAAACGGAATGCAGCATAACCAGGTGGCTGTTTTTTTTCTACGGCTGTCCAATCCACTTACAAAGTTTGGCCTCAGTTTGCCTGAGGTAAGCCGCGGGGTTACGGCGGAAGCGTCTCCGTTTTGTTGTTTCAGTCAATCGTTCCTTCCAACGACTTCGTTCTCTGTAGAAAGTGTCGTAGGGAACAGATCGGAGACGGTGCAGTAAGTTTTTTTGCTTCAGGGCATCATCCACAAGGACAACAAATTCCCCACTACGCAGTATGTGTTCGTTCCAACTGCGGCGGCCAGTTGTACGCCGGTGCTTGGTTTTGGTTTGGCGAAAGAATCGTTCGTGGTCGTTATTCGTTCTCGGAATATTCGGGGTATCGTAACACGTAAAAAGCCCCTTCCAAAAACCTTCAGTGTAACTCTGAAAATTGGTTAGGAGGGGCGTATCCTCCGTCCTAGTGTATGTCTGCTGCATCCAAGACAGCAGACAGCCCATTTCCCATCGAACCGTTTCACTACTCTGGTCCGCTTTTACAAGGGCAGGCTCCAATATTCTGGCTGTTTCCTGAATGGGGATCTGCCAACGCTTTACAGCTTCATACTGAGCAGTCAATTCCGGCAGCTTTCGGAAGAGTTTGGTTATTTTACTCAGGAATGAAGGCCCCCTTTTTTTGCTTCACTTTGCTCCAGTGAAGCTTTTACTGCTTGGGCATTTTCGTAAATCCGAATACCAGGCAAGTCTAGGGGAGGGGTGCCGTCTTCCAAAAGCAGCGAGCGTGTGGCGGCCAGGTAATCCCGGGCTACTTCGGCTTCTACAGTGGACTCGTGCTCGACCTGTTTCTCAATTTCCCGAATACCTCGCAAGCTTTTTTTAATCTTCGGGTCTTCAGTTTACGGTCCCAAAATCGACTACCGGCTTGGCAATATCTTTGAGATAGTGGTACTGGCAATATTGGTAAGGGGTGTCACCCCATGTTTCCTCCATAGCCATACGGATCGACCGTTGGCCATCACTTACCAACCCAACAACTGGATAATCCAAGTCCTTAACAGGCTTTAGCAGAGCTTTGAGCTCCGAGCACGATCCGCTTTTCAGGTTTTTGGCAGCTAAAATACGACCACTAAATCCTTCGCGAACAACATAGAGCGTTTCATTACCTTTTTCGGGCTGAACCCCATCCATAGACAAGAGAAGGCCGCCATGTTCCTTTACGATTTTTTTTAAATCTTCCTTTACATCATCGGTTAAAGAAGCGCGAAGCAAAGTTAGATACCATTCGTATAAACGCATCGCATGGCGCTCGGAGGTTGGAATCGCTCGCTGGGTCAACGCTTCGGATATTTCAGTAACCGTCATATGCTGTTTGAAGCGCATTTCTCCAACAAGCACAAGAACGTCATAAGCATAAGATGTATGTTTTAAACATAGGGCGTCCGCTTGAGCCGAACGAAAATAACGCTCCAATTTACCGCAGGCTTCGTTCGGGCAGTGGTAGGCCATATTCCAGACATCTAAAATTCCCTTCAGTGTAGCTACAATCTTATGTGAAGCGGTATGATGCCGCTTGAGCTTCGTACCGCAATCCGGGCAGTGTGTCAGCTCGGGACGGAAGTAGATTCTTTTTTCAGGAATAAGTCGATTTCGAGGTAGCCCTCTTCTCGCTTTCATGAAAGATCCCTCCAAATGGTCTGTACCGATAATTACCCATTGGAGGGGGCAGTTAGTAAGTTAATCAGCCGTAGTTTTTTTTAACATTCTTGACCTTTACACTAATGTGAAACTTTATAATAAAGTAAGTGTTCCAAAGCTGTGAGGTGATCGTTTTGAAGATAGGAAAGGTAAGAAAAATAACCGGCGTTAGCGCCCGGTCGATTCGCTATTATGAGGAGAAAGGATTGATCAAAGCATCTCGTCAAGAAAATAATTACAGGGAATATGACGAAAAGGTGATCGATTCCATAAACGCAATTCAACTCTATCTAGGGTTAGGGCTTACAACGGACCAAATTCAAGACATCATCTTCTGCAAATATCCTGAGCATCAGGAGCATAAAGATAAGGACGTCTATTGTGAGGAATTACTGCTTATGTATCAGTCGAAAATGCAAGAGATCAATCAACAAATAGCTGCATTAACCGAAGCGAAGTTCAATTTGGCCGAAAAAATCAATCACATGGTACAAAAACGGGAGGAGGAAAACAAGTGACTATATTAGTTACAGGGGCAACGGGAACCGTAGGGCGACACGTCGTGGAGCAACTTATTCAAAAGGGGCAAAAGGTGCGTGCATTGACACGTAATCCGCTGCAGGCCAATCTTCCTAATGAGGTAGAGGTTGTTGCGGGAGATTTAAGTGATCCAAGTACGCTAGTTTCTGCGTTGGTTGGCATAAGCGGCATGCATTTAATTACAACAGGCGCTGAATATACCCCGTTACAAACAGGCCCAGAAATTGTTGAACTTGCTGAGAAGGCTGGGGTACGCAGGGTTACCCTTTTATGGAACGGAGAGAAAGGCCCTTTTGAGAGGGCAATTGAGGCCAGTAGTCTGGAGTGGACTCAACTTCAAGCCTTTGAATTTATGGCAAATGCACGAAAATGGGCGAACTCAATACGCTCTGTGGGGGTTGTTCGAGATATGTTTGGAGGATCACGAATTGCTTCTGTTCATGAAGCGGATATTGGAAGAGTCGCAGCGGTTGCACTAACTGAGGAAGGTCATTCAGGTAAAATATACACACTAACAGGGCCTGAGAGTTTGTCGGTTCCAGATAAAGTCCGGATAATTAGTGAGGTTATCGGACGTGAAATTCAATTTATTGAGAGCTCCGAAGAAGAAGAACGTGAACAGATGAGAAGAATGGGTGTTCAGGAGGATGCAATTGATTACGTGATTAGTTGGCACCTTAATCCGCCTAAAACTGCTTATAAGGTTTTGTCGACAGTTGAGGAAGTAACAGGACATAAGCCGTATACTTTCGCAGAGTGGGTTAAGGAGAATGCAGGATTTTTTATATCGGATGTTTCTTGAATCTATTATTTCGAGGTAGTGAAATAGAAAAACGTGTCTGAGTGCATCTCTGGTAACTATGAGGTCAGGGGTTCGTCTGCGTAAGGAGGCGAACCTCGAATTGTTACGGTATCGGGTAACGATAGTACAACAACTAGGGAGCAGTTCGCCGCGCCAGCTGCTTCCTTCTTCATTAAAGTAACGGGCAGGATAACGCAATGGGGCCGTAAATTTGCTCGATTAGCAACACCCAATGACCATCATGCGGGAGACCTTGCATTGCGTCGGAGCATGCTATGCCCAATCCAATAAAAAGAAGTCGACCATCTCGTTGGTCGACCTATACTTACATTATTGTGCGGTCAGGATCTGTGGACCTTCAGCTGTAATGGATCGGCAGCTTATTGCGTTAACTGAATTATAATGAAATCAAGGTCGCTGAATAAGGTTCAATGTGAGACATTTAGTACTCCAATGTTTCAGGGGAAATAAGCACAATATTTCCATTTAAGCAGCTTACTTCTTCGCATGAACGTCGTATAATGGAAGCTGATCATCTCTTGTTGAGTCTCGGAGGTACGAATCATGAGCAATGTGAACGCACCATTTCGGGCAAGAATCGGATTGTTGAACGACGGACCGCTTACGTTCGATCAGTTGAGCACTGTTCTCGAACGAACGGCATTCGCGGTCCCTTTTGAAAATTTTGCAATCATCGAATCCAGAACGCAGACCATCTCAAAGGAGCAGCTTTTGGACAAAATAACGGTTCAAGGTGAAGGAGGCCTATGCTATGAATTGAATACACTGTTTTACTTCTTCATGCTGGACAACGGACTGGACGCCCGGCTGGTCAGCGGCGTGGTATACAATCACGAGAAGCAGCGTTACCCGGCCACCGGACGTACGCATGTTACGATTCTGCTCCGGCATGAGAATCGGACTTACCTCATCGATACGGGATTCGGCAGTAATCTGCCGCTGCGACCTTTGCCGTTATCAGGCGAGCCTGTCTCCTCTTCGAATGGGGACTTTCGTATTGTCCCGGCGTACGGCGAGCATGCCGAGCTTGGTGATTACGTCCTGGAGATGAAGCTGAAGCATAAGCACAGCGAGTGGATGACCGGCTACGTATTCGATACCGCGAAGACTATTACCGACGATACCGAGCTGAATGCGATTCAGCGCATAATCGCCGAGCATTCCGACTCGCCGTTCAACAAGAAACCGCTTGTCACGAAGGTCACGGAGCGCGGAACGATCACGTTGACCCCCTCCTTCTTCACGGAGTGGTGTGACGGAGTCATGACCAAGACACCGGTAGACGAGTCTAGCTACAGGGAACTTCTGTGGCGATATTTCGGGATGCGTAGACCTCGGTAAGATGTTGCGTTGCGTACTCTTTATTGTAAAGGGGCTTGTCGCGATGCAGATCCTAAACTAGAACAATGTGAAAAGTTGAGAGAGAGGTGGAGGGCCTAGCCTTGCCTCCTTTTTGTCTGCCCGCTGAGTCTCAAAAACGGCCGTTTAAGAAACAATCTTTAAGTTACTATGAATCCCATACATTCGTGTAGTCTAATGGTGTCTAAACTCGTGCCAAAATCTATGTTACATAAACGTGTGTTTATGATGCTATTAAGGCGTGTACCGGAAAGAAAAGTACACAAGAAGAGGGACCCGAACGATCATATTTCTGGGGACGGAATGTGCTTTTCTGATCAAAACGAAGAACGATGGCACAACAACCAGGGAGCAGATCGACGCGCGGCAGCTGCTCCCTGGTCTCGTTAAAGTAATGGGTAATAAGCCTGTAAGTGGACCTTGTTTGAGCAAAAGGTCAATACAATTTGCCCCCTTTTTGCCCCCCACAATTTGAAAAGCTATGAACCTAGATGAAAATTGATTCTCAATAAATTCCTTATTTCTCGAGGTTTTTATGAGTTATAAAACCCAATAAAAGCCTTCACTAATAAAGTTCGAGATGGAAGGTTCGATCGGTTAAGCCTTATAGATCAAGGGTTTCGGTGGGACCAAAGTGTGGTTTGCCCACATTTTTCCCACCGATTATTTTTGAACATATCTTTCGTAGAGGGCGAGCGCATCGTCCTCTATTTTTTTTGTGACATGCAGATACGTGTCTGCGGTAATTTTTACGCTTGCGTGTCCAAGTCGCTCGGACACGTATTTTATATTTGCGCCCGCTTCAAGTAGGTGGACTGCGTGAGAATGGCGAAGTGCGTGGGGGGAAAGAACGGGTAAGTTTGCTCTTTTACATACGGCTTTAAAATAATCACGAACGACATTAGTACGAAGCCATCTTCCATCATGCTGATGAAATACAATATTGTCTTTTAACTCATGAATTCGCAGGATTTCACCCTTAGCAGAATTGTAGTATTAGATGAATGCTAGAGAAGTTCGGGGGTTGGGGCAGAAAAGGGTATGCGGGAATAGAGGGAAGGGAACTTCCCCCAGTTTGTTCCATATCATGCACGTCTCCATTTCGCCCTTAGAGATTCTCACTTCCATGTCTCAACGGGTCATAGTGTCATCTATGAAGGTACAGAAATTATTGGTAAGGACCTACAAGTACAGAAAAAGCAATCATTGATTGAACTAAACCATCGGCTGCCGGTTATTATCCGGCAGCCTTTTTTTCGCTAAGGGAGGATTAAAAACTGAGCACTATCATATTCATAGGTCATCGCATTACATTGCCTATAACTTAGGTGTACTAAAAAACATGCGCACATATAAGTGATACGTAATAAAGGGGATGCCCTCCAGATGATGTGTGGAGGCATCCCCTTTTTGGTAAAGTTGATTAAGCTACCATGAAAATTCATCCTCTGTGGTGCAGCGCTGATTATTGTGCTGCATGAATGGCTAATGGCAGGCAAGATAGGAGTAATTCAGGGATAATATTATTTTTTTGTTAAATTTATCCAAGCGCAGTTTGTTGTGTTATATTTAATCGGAATTTATTCATAAATTTAAGGAGGATTTACAAATGTTTAACAAAAAAAATGTTATCATCGCAAGTTTTTTTTTATGTTCATCTCTAATTTTCCTTTCAGCAGGACCAACAATTATTAAAGCTGATTCTGTGATCACCTACGAAGGAACCAGGCAAGCTGCGAAGGAGAAGGCAGATCTCCTCACGAATACTTACGGAACGAACAGCGTGCAGTACGCCATTATCGATCATGGCAGCATCGTCGTATCCGGCCAATCCGGCAAGAATAATGAGAAGGGACAGAATCCGCTCACGAAAGACACGATGTACGGGATCGGCTCGACGAGTAAAATGTTTACCACGGTTGCCGTCATGCAGTTGGTCGACCAAGATAGAATCGATCTCGATACGCCGATCGTCCAGTATATCCCCGAGTTTACGATGAAGGATGAACGTTACAAGCAGATTACGCCGCGCATGCTGCTGAATCATTCTTCCGGTCTGGACGGATCGTCGATGACGAACGCCTTTTTATTCGAAGATAACGATACTTACGCCTACGACACACTACTGAAGCAACTGGCCGGTCAGACCTTGAAGGCGGACCCCGGCGCTTATTCAGTTTACTGCAACGACGGATTTACGCTGGCCCAGATTCTGATCGAGCGAGTCAGCGGTATGGACTTTACCTTTTATATCCATCGATATATTACGGAACCTCTGGGTATGGCCAATACGGTGACGCCGCTCGATTCTCCGAACACAGCGAAGATGGCGGGACTCTATTATCCTACCTACGCAGGGCAACTTCCCAACGAGACGTTCAACGTGATCGGAACGGGAGGCATTTATTCCACGGCGGAAGATTTGGCTCGATTCTCGCAAATTTTCACGGGGGAAGCGGAAGAAGTCTTGTCCGGCAAATCGGCTGCGGCCATGGCGCAAGACGAGTATAAGACACCTTTGTGGCCTGATGATGCGGACAACTCAACCGAATACGGTCTCGGCTGGGACAGTGTCAATCTGTATCCCTTCGGCGAATACGGAATAAAGGCGCTGACCAAAGGCGGGAACACGTTTCTCTATCACTCATCGCTCGTTGTGCTTCCCGAGCAAAACATGGCAGCAGCTGTCGTCTCTTCCGGCGGGCGCAGCGAGTTCGACGAGCTTCTGGCGAAAGAAATCCTGCTTCAGGCACTGAAGGAGAACGGGACAATTGCCGAATTTAAACCTGAAAAGTCGTACGGTGTGCCGGTAAAGGCTAATATGCCGGAGTCCGTGCTGCAGTATTCGGGAATCTATGGCGCGACCAATACAACGATAAACATCGATATTACCGAAGGCGGCGTCATGTCCATTACTTCGGAGCAGTCGCCCGATAATCCGGCCCAGATCTTCGAGTATTCGGCGGACGGCACGTTCAAGAGTGCGGATGGGAATGTGATGATCAGCTTCGTGACGGAGGAGAACGGCCGCATCTACTTATGGATGCGTCAATACGCTTCGCTGCCGGGTCTTGGGCAGAGGGCAGTTTCAGAGTACAACGCCGAGAAGCTCCAGCCCCAAGATCTTCCGACAGAGACAAAAGAAGCATGGATTCAGCGCGACGGCAAGAAGTATTATCCACTGAATGAGAAGTATACGTCGCTCATTTATTTGGTGTCGGGAACCATCCAATTGAATGTGTCGAAACAATTGCCGGGGTACGTGTTGGATAAGCGAATAACAGGCCCGAATACGGCCGTCTCCGAATTGCAAATTCCAGGAACGAGCGGCCGGGATCTCTCAGGTTATACGTTCTTTACACTGGACGGCGTTGAGTACCTGAATATTGGTGGAAGCATCTTAGTAAACGAGGACGCCGTGAAGCCTGTCAACGTCGCTGAGAAGTCAATCGTTACCATTCCGTCGAGCGGCTACGCCAAATGGTATACGATAAGCGATAAAGACGGGGGCAAAACCGTTAAGGTGAGCATGTCCTCGAAGGCTTCCTTCGCTGTTTATAATGCAGAGGGGACATGTATCTACTTCAGTGTCATCGGAACCAATGATCAGGTCGAGCTGCCTGCGGGAGGATCGATTGTTTTCGCCGGGGATGCCGGCACGAAGTTCGAGATTTCCGCGCAGTAACGTCGCAATAGGTATTTCATAACTGGCCAAGATACAGTCCTGCGTATAAGTAAGAAGAAGACTCCTCAAGAAAAGTTGGAATTTTCATGATTCCGTGGTGCCGCGTTCGCGTGGCATGGATGGCTAAACATTCCTGTATAGCCTAAGAAAACGGCTTTGTCAAAAAAGGAGCGCCTCGGTATGATGGGTTTGTCCACTACACCATCAAGGAGGCGCTCCTTACTATGAAGTTTAAGCAATCTGACGCACAAAATCAACGGATTGAACGAATTACTACCTCTCACCTGGTTGTAGGAATTGATATGGCAAAGTAAACTCATGTCGAAGAAGCCACCAACTTCCGGGGAATCGTCCTTTCCAATCGGCATCTTTCCTTCAAGAACAAAAAAAAATAGAGGACGATGCACTCGCCCTCTACGAAACATATGTCTTGCCCGGAAACCGGGCAAAAAACGGACAAAAGCTATTAAACGATTCAGCAAACCCTTGATCTATAAGGCTTAATCGATAAATCCTTCCGTCTCGAACTTTATTAGTGAAGGCTTTTATTGGGTTTTATAACACATAAAAATCCTTGAGAAATAAGGTATTAATGAGAATCAATTTTCATCTAGGTTCATTGCTTTTCAGGCTGTGGGGGGCAAAAAGGGGGCAAGCTGTATAGACTCTTTGCTCAAACAAGGTCCACTTACAGGCTAATTACCCATTACTTTAACGAGACCAGGGAGCAGCTGCCGCGCGGCGATCTGCTCCCTGGTTAATGTAGCCGCGGTCATCTGGCCGGCTGTCTAAATAAAAGCCTCTTCGCATTCAACTAACGTTCCCCGATAGTTGAACGAGCGTCAACAATCATTCCCTAAACAAATACTCCCTCTGGTCTTTTTTGTTATATAATTCCCAATGCACGTCGGCTATCCGGTCTGGATCGTAATACGTCCCCTTTTTGACATGATCAGCGATTAGAACCTGACCTACATAAATTCCAAAGGGAGACACTGTCTCCGCTATTGAAAGTGCAAGCGAGCGGGTCGCTGCTTTGCCGATGGATAAAGAGGTATAAAGGGGATTCGGATTCAGCGCAATACTGCCACCTGTGAAAAAGAGTGTCCCCTGTTTACGTTCGACCATATCCGGAATTACTTGTTGAGCGCTGGTCAACGCACCAACAGTATTCACCTTAAAATCTTCAATAAGCTGCTGTTCAGTTAACGAAAGGGGATCCCCTGGCACGATGTGTGCCGCATTATATACCAAAACATCGGTGGTTCCAAATGAATCTTTTATCTGTTTAAAGGCTGTTTTTAATGAATCCGGATCTGATGCATCTGCAGTAATTCCGTGCGATTCAATTTGTAACTGTCGAAGGGATTCCAAGCTGCGTTGCAGTGATGATTCGGTTCTTGATATGAGAATCACTCGGAAGCCATTGCTTCCGAACTTTTTGGCTATACTGGCGCTTACTCCCGGTCCAGAACCGACGATGACTAACAGAGGTTTATGGCTCATCCTTACCACGCCTTCTTTCTGATATTAGTTTAAATACATAAATTTGGTGTTTCTATATTTTTAATAATATCGAAATATATAGATTCGTCAACCACTTCTTCTCAGCTAAGCAGTGCAACTGTTTATTACGTTATTCTGCCCTTTAGCCATCCATGCCGCGCGAACGCGGCACCACGGAATCATGAAAATTTATACTTCCTGCCTTATACTATTCTTACGGCTGGTGAGGAAGGTCGATAAGCTATGGTGTTGCGAACCCAACCTTTAGTCTGACTCCGACGACCATGGTGCACCACGGAATGTCGCTCCCTTTGGGGAAGCACGCAGGGTAGATTAACCCTTTTGCTGGTTGTTGCGCCAGTCCTCAATTCAATTTGCCGAAGAAAGGTGAGTATCATGGAAGTTCTTATTGAACGAGCTTGCGGGTTGGATGTTCATAAGAAGTCCATCACAGCCTGCATCGTTACTCCTGAAGGAAAGGAGATCAAGACATTCCGTACCCATACGGTCTTTCTTCTTGAACTTATCGATTGGATCAAGGAACACCGCTGCACCCACGTGGCCATGGAGAGCACCGGCGTTTTTTGGAAGCCAATCGTCAACCTGCTTGAAGCGGAACAGATTGAATTTCTGGTTGTGAATGCACAGCATATGAAAGCCGTTCCCGGCCGCAAGACAGACGTGAAAGATGCGGAATGGATCGCCGATTTATTACGGCACGGCCTGCTTAAAGCGAGCTTTATTCCGGACCGGAACCAACGTGAATTGCGAGAGCTGGTTCGCTACCGCCGAAGCTTAATCCAGGAGCGTGCCCGTGAACACAACCGGATTCAGAAGGTTCTGGAAGGGGCTAACATTAAGCTGGCTTCTGTCGTTTCTGACATTATGGGCGTCTCGAGCCGGGACATGCTGGAGGCCATGGTGAATGGGGAGACGGATCCGGAGAAGCTGGCAGGCTTCGCACGCCGAACCATGAAGAAAAAGAAAGAAGAACTAGAGCTTGCGCTGCGGGGGAACATGACTGCACACCAGCGTCTCATCCTCAAAAGCATGCTGACGCATATCGACTTCCTAAATGAACAGATTTCCGAACTGGATATGGAGGTAGCCAAACGGCTCGACCCTTTTCAGCAAGATCTGGATCGCCTGGATACCATTCCAGGGGTCGCCAGACGGACCGCTGAGCAAATCCTGGCTGAAATCGGCACCGATATCGCCTCCCGTTTCCCGAGTGCACCACACCTCTGCTCGTGGATCGGCCTTGTGCCGGGGCATAATGAGAGTGCAGGTAAGCGCAAACCCTCCAAAACCCGAAAAGGCAACAAGTACCTCCGCTCTGCCCTCATTGAAGCTTCCCATTCCATTCGAGGATCGAACAACTACCTCGGTGCTCAGTATAGACGCATTGCAGCCCGTAAAGGCGGACATAGAGCAGCTGTTGCAGTTGCTCACTCCATCATGACTATTGCATACCATCTGATAACACGCTAGGAAGATTACACGGATTTAGGCTCTGATTACTTTGAGAAGCGAAAGCAAGACGCCATTGTCAGACAGACGGTTCGAAAGTTAGAAAACTTAGGATACTCTGTTACTTTGGCCACTACCGAAGTATCTTAGTTCTGAAATAACATCATTACTTGGAGGAAGACGCAGCTTTTAAAAAATTGAAGCAGCTGCGCCTAGTTTCGTGCTGCCTTTTTAGGCTATACGCTATGAGTTATTTTCAGGGTAGCTTAACGTCAACTAGGGAGCAGCTGCTCGCAGTGATACGCTCCCCATACGGTAGACAGGTGAAATAATAAAAAACCTGTTACTGTAAGGGGAGCTTTTTCATGTCTAAAGAAAAATACTGTGCTACGGAGAAACTTGCTATCCTTGAAGAAGTTTCAAGTGGAAAAATTGGTTTTATCGCTGCAACCAAAAGATACGGTATGAATAAAACAACTTTAATGAAATGGCAGCGTCGTTATAAGCTATATGGGTATGAAGGACTGGAAAGAAGTACTCGCAATCGAAGTTACAGCGCTGAGCTGAAGCTTCAAGCGGTGAAAGATTATGTAGAGGGTGGATTGTCAAAATACCGGATCATCGACAAATACAGGATCTCAAGTACAACGCAGCTTTCTAACTGGATTAAGAAGTATAATGGTCATAGCAGCTTAAAAGCCTACAAAGGGGAAGCACAAGCTATGACAAAGGGTCGCTCTACTACGTGGGATGAGAGGATCGATATCGTCCACTATTGCCTGGCACATCAGCATGACTATCATAAGACAGCTGGCCAGTTTCAGGTCTCCTACCAGCAAGTATATCAATGGGTGAAGAAATTCGAAGCCGGCGGTGCGGATGCTTTAAAGGATGGCCGGGGGCGAAAGAAGGCGCCGGAAGAGATGACGGAGGCAGATCGCCAGAAGCTCGAGATGAAGAAGATGGAATACGAAATGGAGAGGCTTCGGGCGGAGAATGCATTTCTAAAAAAGTTACGGGAAATCCAAAGGAGGCGAAGCTAAGCCAATATCGCCAAGAGAACGTCTACCTTGCCATCCAAGCGCTTCAGGAAGAGGAGTCGATCAGCATTCAACTTCTGTGTGAAGTCGCAGGAGTTGCACGCTCAAGCTATTACAAATGGTTAAACCGCAAACCCAGCTCTCGTGAGCAGGAGAATGAGCGGCTGACAAAGATGATGATGTCCATATATGAAAAAGTAGAGAAAACCTTTGGGTACCGCCAATTAACACTCCACATGCGCAAGGAAACCGGACAGACGATTAACCATAAACGCGTGTACCGGCTGATGAAAGTCAAGGGAATCCAGTCGGTCATCCGCAGGAAGAGAAAGAAATACCCTCATTCTACTCCCCAGCACGTGGCCGAGAATGTGCTGAATCGTAATTTCCAAGCAGCTGAACCCAATGAGAAATGGGTAACGGATGTAACAGAATTTAAATACGGCAACGGTCAGAAAGCGTATTTAAGCGCGATTCTCGATCTTCATGATAAATCCATCGTCTCCAGAGTAGTGGGGCATTCCAACAACAACCCACTTGTTTTCGAGACGTTGAAGCAAGCCTTGCAAGCAGCTCCAGGAAGCAAACCAATGCTTCATAGTGACAGAGGATTTCAATACACTTCACTTGACTTCAAAAAGCTTTTGGACGATAACGAACTGACTCAAAGTATGTCCCGGGTTGGGCGGTGTATCGATAACGGGCCGATGGAATCCTTCTGGGGGACCTTAAAATGCGAGAAGTATTATCTACACACTTACCAAACCTTTGAGGAGCTTGAGAGAGACATTCTGGCTTACATCGATTTTTACAATAACGAACGATTACAAGCAAAACTAAACGGCCTCAGTCCAATGGAATACAGGACCAAGGCCGCTTAA

Protein sequences of DBSCAN-SWA_1

>NC_016935|1641032:1714652|1669074_1670688_+|WP_014369000.1|DBSCAN-SWA
MSRFKPWPGTNASPGGGSGNGSLPRSYEGIEVVWWGNSIIEGQGLTDLQKFQTQLAKLNGMVNRIYGYPGKPWGYKGTGPDDTIYSNRALLPKTAKLYAMYGGGNDNRLNIPRGNVDDMVNTTFAGAINLGIVYIKTNMPGAKIVLITSLQRNGGDDGTGKPITGTTLNDLKLSLIDYNNMILAIGQKHDIPVWDLYNCGINNASIPKYMQSDGVHLNAQGAAKVALCGYGFFETIDLSIVSPPADTTAPTVPGKPTLTSKTHNSVTIAWTASSDAVGVTGYIVTGGPSPVNVTGTSATIPGLTPETNYTLSVKAKDAAGNVSAASEALTVTTDAAPTGGGGTTVTTYYENTFTGADGSANGQVAESGQATNTATAVTPDNWVISGNRMKYSGTTGDRIIMSTSATGGDYTTEAQIYPAGGKAGVVFRAKDGTEYMWVRFDQAGNAGEEIKMFKKHESTGANTQIAAGPVKINTTGSNIVKIVCAANNVKVFVDDNQAINYTLTAAEQAKYGDNTGVGLYAGGENASTWEYLKSYSN
>NC_016935|1641032:1714652|1671242_1675685_+|WP_014369002.1|tail|DBSCAN-SWA
MAEEEAGSVVVKVGMDGSGFQNGISNINRQLRLIQSEFAAASAKLGDFGNSAEGLKLQSDALSKQMSLQQQKVDALQKAYEKAAESKGKDAKATQELEIKLNKAKEELAKTEKKLESVNEEIEKQNNRWNKLAGTLNDIRDRFQALGDQLSGIGGMLSATLTTALAGIGIGAIGAASDVDKSAGKMQASLGLTAEEADKLSATTQNLWKDAFGESMEDVTQGLITVKQNMQGLDDGSLEKVTKDAFTLRDAFGAEVNETTRTASVLMKNFGIDGSTAMDLITVGFQKGGNFSDELLDTMREYAPQFRAMGIGAEDMLGILIKGAETGAFNLDKVGDALKEFNIRAKDGSELTSQAFSALGFNADEMSAKFAAGGETGKVAFQAVTVALAGLQDPLTRNAIGVALFGTQWEDLEAKVVTSMATGIGSVTGFQGATQRAGDALRDNLGVRATKVWREFQTALQPLGEMMIGLAEEILPQVSAAVQSLTQWFSNLSPDGQKLTLVLGAIAAAAGPVVMIVAQMVGAVTTLIGAFSAVSLKIAAAGGVMGLLTGPIGITIASIAALAAGAYLVVKNWDQIKSFFSGLGSWLSSYFSNLVSTVTTYGQFIMTGLMAGINSKLQPVINMITAVANGITSSFRRIMGIRSPSKVMEEYGQFIDEGLVQGMALGQDSVLEQTQSIADGIKQTMEKNIGMLNKLGEAIVGALRKQYEEMESIQTAALDKQLENEKKASDERQKVYDKEYAEKLKLIDEETYNKVKAVQDQIDSIDSQTSNEEKALKAQEEQTRLAELQKKIAAAETAEERARLQEELSSTIAKYEREQLLEQRNNQKETLKKQIEGLKEASAEQKEMLKADLDSKKEQEKLRASQVEESLKAEKDAVKKHFDELTTQENLQLEARKLVVDKNNQEIVDLLQKYNPSWQNAGQSFADSLINGINSEKQSIADAVGKTIDLQPMVQKQMSVLDELQKKIASLQQAEKAEAGAAGEESPFPDSGGFAGSGGGDIGGLGAAADNTSAKLEGLMQTTTTLQQDLTGNFIPSVEGISGAWNGVMNSSSNVWGQITSNLTQTWAGIASQAQQVWSGITGFFTSSWNSFLSVATSVSNGIHTGVTDTWNNISAHINSVVSEIVGTVMTIFGGMSAGISSVFSGIESIISGSWTVIKNVTLGSILLLLDLVTFNFTELTSHAGQIWENLRTAFRLIWEGIQLVFTSALETLKGGLATSWGLMKTDLIQSWNEAEAYLSTLWVNIIDQASTGWTDFKTSVTKLVEETISSTRTKWDELLSWFGELPEKLKGYAENMFRSMRDGFNNTVNEVTSAVRNGLDGAFDYIKKLPEEALQWGKDIIEGLIKGIRSAIGSVKAAIDSVASTVKGGITDALGIRSPSRVMMEYGGFTTEGFALGMKGGLSRVASAARTIASAAFPKVDLPNMAAPAGRTAVPASSSGGFVQNITINSPQPLSPAETARLNLRASRQLAMGWGLDGA
>NC_016935|1641032:1714652|1699108_1699438_+|WP_014369027.1|DBSCAN-SWA
MLENLTEMLKGVLEGCVLEIISRKETYGYEITRRLNALGFTDVVEGTVYTILIRLEKSKLVEVTKKPSDMGPPRKFFALNDAGREELQRFWGKWEFVSSKMNELKEMKS
>NC_016935|1641032:1714652|1663381_1664647_+|WP_014368990.1|portal|DBSCAN-SWA
MGILQRVISWFGLGARLETRANRNLGGFQKWFEPYNMFARSGQLDASNETIFSAVSRLSNSMASLPLKVFRGYKQVSGSPIAQLLEYGPNPNMTSFDFIRTLEAFRDTSGNGYALIERDAKYQVQALWLLNPRKVKPVQESSTKELWYEVQGDDGTYYIHNMDMIHVKHFHTVGYEGISPLDVLRNTINYDTQVKQFSLSQMESGIKASFILKLNGSLSDEKKKAMLQNFADFYSKNGSGVIVIDSGQDLKELKQDIIDLKVFEVERITRSRVAAVYNMPPHMLGDFSQTSFSSMEQQALEYVQNTLLPIVRMYEQEFSRKLLTTKERSAGTVIKFNMNGLLRGDIKTRGDFYFKGVRSGWFTPNEVRAYEELPPEKGGDKLYMSRDLAPIDSPDRSIAPGKEVNEQDESEADNDTGSEPE
>NC_016935|1641032:1714652|1642695_1644093_+|WP_013914840.1|DBSCAN-SWA
MAKKMPEMEDYKYGFRDEHKAIFQSGKGLTKEIVTEISRMKGEPEWMLEFRLKSLEQFFKMEMPTWGGNMDDLDFNDIQYYVKPSEKQGKTWEEVPTEIKETFDKLGIPEAEQKFLAGVSAQYESEVVYHSMQKDLEDQGVLFMDTDTALREYPEIFRKYFGTVIPPSDNKFAALNSAVWSGGSFIYVPKGVKVEIPLQAYFRINSENMGQFERTLIVADEGSFVHYVEGCTAPVYSTNSLHSAVVEILCLKDSRVRYTTIQNWAPNIYNLVTKRAVAEENATMEWVDGNIGSKLTMKYPAVVLKGRGAKGMVLSIAVAGKGQHQDAGAKMTHLAPDTTSTIVSKSISKHGGKVTYRGLASFGRNSQGSKANIKCDTLIMDNESTSDTIPYNEIMNDNITLEHEATVSKVSEDQLFYLMSRGLSEAEATQMIVMGFIEPFTKELPMEYAVEMNRLIKFEMEGSIG
>NC_016935|1641032:1714652|1649812_1650004_+|WP_148279666.1|DBSCAN-SWA
MNRLETTLDENEEYIGSTVWKALEEAFERVDDEADEIERELEEAQQRIEELESALEALKYASS
>NC_016935|1641032:1714652|1699796_1700120_+|WP_014369029.1|DBSCAN-SWA
MKIHDIIQGKKEWRAHVARVKALPQDYQIVYKEIQKYFFKVGPVELTEGTGLLSGIVDLFEEGAASGKGVLEVTGRDVAAFCDDLIKDSKTYADIYQQSIDQKGNKK
>NC_016935|1641032:1714652|1646678_1647128_-|WP_187297997.1|DBSCAN-SWA
MITQSEAEHLLNMLKIIKGRNSNNIVLPPLGQEQRLDVESKIYKDENFVININRKGKLKPTKCTYLTLYNKSTILLRLDIDGPAHMNPDGNVIPCPHIHIYREGFDDKWAFPLENEIKTDTSDLLSVLIDFLEYNNIENIPTAFSRTLF
>NC_016935|1641032:1714652|1698056_1698758_+|WP_014369026.1|DBSCAN-SWA
MTTTEKGTRILIIDDEPQIRKLLKVTLQAHNYQVEGSETGEDGIIKASGAPPDLILLDLGLPGLSGMEVLNRIREWSSVPVIVLTAKDREEDKIAALDGGADDYVTKPFSMGELVARIRVALRHAAKTVHEPVLKFNELIIDLSQRNVVLGGERVKLTPTEYDLLKILATNADKVITQRQLLQQVWGGHHSESESHYLRVYISHLRKKLEEDPTRPKMIVTESGIGYRFVTPE
>NC_016935|1641032:1714652|1713944_1714652_+|WP_014368331.1|transposase|DBSCAN-SWA
MMMSIYEKVEKTFGYRQLTLHMRKETGQTINHKRVYRLMKVKGIQSVIRRKRKKYPHSTPQHVAENVLNRNFQAAEPNEKWVTDVTEFKYGNGQKAYLSAILDLHDKSIVSRVVGHSNNNPLVFETLKQALQAAPGSKPMLHSDRGFQYTSLDFKKLLDDNELTQSMSRVGRCIDNGPMESFWGTLKCEKYYLHTYQTFEELERDILAYIDFYNNERLQAKLNGLSPMEYRTKAA
>NC_016935|1641032:1714652|1685521_1686067_+|WP_014369016.1|DBSCAN-SWA
MTLWVNFSLNEISILVLNTAVYVLMFFLPRKLTSQVRTLSLLWGFTIGVIFDFTIGGGLIDFYMVNDSNHFEAFDFLYYFLFAPFGYFFFYFYEILRINKKTFIPYVLAWSVVGVAAQWAFTFLEIITFQKGYKVPYSFPVFLVTQTLTGIYLERVKSRQPIMAAPKKKESRKYVLRRWLT
>NC_016935|1641032:1714652|1648470_1648707_+|WP_014368965.1|DBSCAN-SWA
MIITSKEVSAELRKKRRAAGYSQEDMAGYLGVTQATISKYERGRIPDAATYKMWLWFCENPPIARFEINLDGRNNQHA
>NC_016935|1641032:1714652|1679384_1679660_+|WP_014369006.1|DBSCAN-SWA
MYAIYNDGGRPNGIIPNVTEEMAATLPQQYVLFDGDPPEVPAGHRLMVNFEAKEVGTEPIPTPPKTPEQEIEELKNEISVLRTTVNYLLGV
>NC_016935|1641032:1714652|1693479_1694049_+|WP_014369023.1|DBSCAN-SWA
MKLIVSSIRLSLVLMVVCGLLYNLVVTGIAQAVMPHQADGSLVYDENQNVIGSELIGQHFVDPKYFQSRVSSIGYNGAGSGSGNYAPSHPDLLARVQKSLESWKKENPDVPVSRLPIDLITNSGSGLDPHISPEAAEAQIPRISKLTGISAEKLQELVKDHTAARELGFLGEPVVLVLQLNLALAELTK
>NC_016935|1641032:1714652|1645264_1645807_-|WP_014368960.1|DBSCAN-SWA
MDLKKYQTTHLEDFVDNLYSRINIFRPEQLTIKDIAAALNIKIAYSSISFSSMRNGVLTVHINDQASEEEQWKQFLHELCHVKRHAGNQLKLHPLMRKWQEWDAENFVLYASIPFLMLRRISLPQDQHAAIELITNTFRVSAEMAYTRYHQIARRVYYSIWGGYTNGVLSKTGRYVGVPN
>NC_016935|1641032:1714652|1682264_1682900_-|WP_014369012.1|DBSCAN-SWA
MDKNLQSELQTVSEKLKNLHTDYWNQYIFSWEWYLLLGILIVPWLIVVLLFRHQRLKKAEYAIFTLLVSFLASLLDQLGLGFNLFLYPIKIIPAFHTFLPGSLSVFPTVLLLLFHYYYTNSMKFFAGVMFFAAATSFIAQPLLVYWDMYEINRWHYTASFVTTVFIAAAARYLTNKITITSPLKKKPSSSKIKKIKISMRWFKQKARKTTG
>NC_016935|1641032:1714652|1713096_1713774_+|WP_014368330.1|DBSCAN-SWA
MSKEKYCATEKLAILEEVSSGKIGFIAATKRYGMNKTTLMKWQRRYKLYGYEGLERSTRNRSYSAELKLQAVKDYVEGGLSKYRIIDKYRISSTTQLSNWIKKYNGHSSLKAYKGEAQAMTKGRSTTWDERIDIVHYCLAHQHDYHKTAGQFQVSYQQVYQWVKKFEAGGADALKDGRGRKKAPEEMTEADRQKLEMKKMEYEMERLRAENAFLKKLREIQRRRS
>NC_016935|1641032:1714652|1691429_1693460_+|WP_014369022.1|DBSCAN-SWA
MREKKSMMSSAIIQKAVKESFLKLDPRVMVRNPIMFIVEIGFLITMLLIFVPDLFGGTVSRGYNLVVSLILLFTVLFANFAEALAEGRGKAQADTLKKTKQDIKANKIVGHHSIKQVVSSELRKGDVVIVTQGEMIPGDGEVIEGLASVDESAITGESAPVIKEAGGDFSSVTGGTRVVSDQIKVRITSDPGESFLDRMIALVEGAKRQKTPNEIALSTVLTSLTLIFFIVVVTLPFFGNYLNVNLEIPMLIALLVCLIPTTIGGLLSAIGIAGMDRVTQFNVLAMSGKAVEAAGDINTIILDKTGTITFGNRMASEFIPVGGHQEKETAAWAAISSLQDETPEGRSVLELMKKQGFTHDAAVGDGAEFLEFKAETRMSGMDLKDGRKVRKGAVDAVKKWIVAQGGKIPKDLDPSSDRIAKAGGTPLAVAVDQEIFGLIYLKDTVKPGMKERFEQMRRMGIKTIMCTGDNPLTAATIAIEAGVDDFIAESKPEDKIAVIRKEQAEGKLVAMTGDGTNDAPALAQADVGIAMNSGTVAAKEAANMVDLDSDPSKIIEVVAIGKQLLMTRGALTTFSIANDIAKYFAIIPAMFMLAIPQMDALNIMRLGSPNSAILSALIFNAVIIPLLIPLAMKGVAYKPMSSSALLQRNLFFYGLGGVIVPFLGIKLIDLVVHLWV
>NC_016935|1641032:1714652|1703482_1703866_+|WP_014369033.1|DBSCAN-SWA
MKIGKVRKITGVSARSIRYYEEKGLIKASRQENNYREYDEKVIDSINAIQLYLGLGLTTDQIQDIIFCKYPEHQEHKDKDVYCEELLLMYQSKMQEINQQIAALTEAKFNLAEKINHMVQKREEENK
>NC_016935|1641032:1714652|1665309_1666476_+|WP_014368992.1|capsid|DBSCAN-SWA
MPGETTIFQLKETLNDMGTELRSITNKIDEALTNPAARVEEIEQMEVRQRELKKRFDAIKARIEEREQESQRNLEQQKRANPVLHADTDEKRMIAAKAELIRAEILRGQVSDESRNLLGAIKQPTATGGEKFLPTNMSNQLITEPLAKNPLRSMSPTTKIKGLEVPKIAYELDDDGFIGDEETAKEIELTGDKVAFGRHKYKVKARISDTVLHGSDVELTTYVENALRSGLAAKEKKVALATTPKAGEEHMSFYSTQNAIKQVPGADKYKAIKAAIADLHEDYRENAKVLMKYSDYLDIVETLANGNATLYSAPPEQVLGKPVEFSDDATMPIVGDFSYAQLNYDGDPVYDTDKNVDKGEYLFVLTGWLDHQILLKSAFRIAKVVATP
>NC_016935|1641032:1714652|1641032_1642259_+|WP_014368957.1|DBSCAN-SWA
MNIEEIRRQFPILHQEVNGHPLVYLDSAATSQKPTAVIEAVKNYYEWDNANVHRGVHTLGSRATDAYEGAREKLRRFINARSTEEIIFTRGTTTAINLVASSYARAVCKEGDEIVITPMEHHSNLIPWQQVAQATGAVLKYIPLQQDGSISLEDVEKTITEKTKMVSVMYVSNVLGVVNPVKEIAAIAHRHGAKMLVDGAQSTPHLKVDVQDLDCDFYALSGHKMCAPTGIGALYGKKELLQEMEPIEFGGEMIDHVGLYNSTWKDLPWKFEGGTPIIAGAVGLAAAIDFLESIGMENIDRHEKQLTSYALERMVEIEGLTIYGPGQDRAGLVTFNLDDVHPHDVATVLDAEGVAVRAGHHCCQPLMRWLNVTATARASFYLYNTEADVDRLITALIKTKEYFGHVST
>NC_016935|1641032:1714652|1659480_1659717_+|WP_014368985.1|DBSCAN-SWA
MPDRNKVFWILSIVGFLLVIMSPQLASIGADNFVHKMGGVADKDETLRRLETYAAAYRMLGGIFLGIGLYFTFSQEKK
>NC_016935|1641032:1714652|1660281_1660905_+|WP_041619058.1|DBSCAN-SWA
MININKKTPQTEKELLHHLEEQLYFIKASSEAFDKGFLGEAKRLATTIRVLLHDNKTSSQSLLKQLDQKDKIKYYSVLENKDTDNAIIFVGLSSGFENGEFTYYPRLVSPVAKLDFQEWWNQPVLINKPQGLLFTRESIIRNVANTDGGAHVDPGLNEKYYELSRQNGFGWEFHDVEPPSEFKGPELSFTRQIAHELYMSITEQIRI
>NC_016935|1641032:1714652|1683385_1683952_+|WP_014369013.1|DBSCAN-SWA
MTTDGNQIDYSSPSLNLSFDLRSSPYFIKDKQNFLLYQTAKQLPAMQGLSLVDVFLSRGHSVEPHWHPNANELLYMIQGEIVESVLNPFTLQVLSYRVGPLQSVYIPMGWWHWTIAVTDHTRLVVSFDNGQFETTYGSDILRKTPPEVIQIVYGIKAAQWAEVIKPIDQTVVIGPPRGTMTNRNQRSP
>NC_016935|1641032:1714652|1675677_1676529_+|WP_014369003.1|tail|DBSCAN-SWA
MRKISFTNANKERIVLQSTGPYFLTKLEGVAAVRTTVQLNKSPFQDGQTYLGNNLDVREITIEGSIVPGAVTLEERRRTLMRVLNPKLGLGIVRYEDAGGAKEIRAIAEESPVFPDKQHGVYQKFLISFLCPDPAFYDPRIQKVNLASFTGGISFPFSFPISFGRVGQFITLNNRGDLDAPVFITFLGPLKNPVLENKTTGQMIKLVQEIPEGHRLEINTAFGNKTVTKIAEDGTRSNAFHWVAPESEFWGLVPGENEISYQATEESKFGAVTLEYQPRYLGV
>NC_016935|1641032:1714652|1689510_1689618_+|WP_148279668.1|DBSCAN-SWA
MLDIVMVVSFIVLALLMAGLAAWAGKVSDEGAGRS
>NC_016935|1641032:1714652|1668051_1668666_+|WP_014368998.1|tail|DBSCAN-SWA
MAGVRIGLRDLHYAKLLSDNSSGAMYAAPQKIAGAISAKVTPSSTTETLYADDGAAETATALGEIAVELNVKDLTLQQLADLLGRTVVNGIMVSKDTDTAPYVAIGFRSIKSNGKFRYKWLFKGRFSLPAEEYKTQGDKPEFQTPVISGVFVKREFDGWWEVTGDEDEPGFTLGDTWFNKVFEAGDSENPTLPVFVSANQVVFQ
>NC_016935|1641032:1714652|1677660_1679373_+|WP_014369005.1|DBSCAN-SWA
MTEQYRFFGSTEGDVREYNQLEFAEVFDRFFQTGIFPRVGAELKVLETDPQRLAVRVSTGQAWLRGYWYRNDDFKEIELPPAHPEFPRIHRIVVRLDTLNKRDIIALVKAGEPSATPVPLALEQNEEYWEIGLADVYVAAGVTKVDASNITDIRYSGGGGKAVGHDFTDLQLLADQAVAKANASLPKDGSQPMTGALRSAVGSASGGRVHHYLGSTNDVHRVGIGLDGDENGDDQVGSAFTVWAYKNNGQYHKTLMQIWRDGTAFIDGKRVILADSGGSIDSAIIKNSTINDSTLNNPRILWNRDSDYARLEFVDEGANKDILTLTVGDDAQGSDTGIEDFFRLKFGDDTVARFRSQSLTIGEPGSGFEMYKNGDLWQRGELMAPTRVRGGVMEYWDGERWRAAGMSTIVVSGTVQETIHGSAADFAGGSSYGGRKFLVAKHIPKGVGELNIVVDFYNNTNSGGGYTGIQVFSPVQHMSNSSTSGYFAREAYDGYGPLWWHAYGTYWDTDSDFRWNSSLVGGTGGSMGASSWATYETTVKVSTKMPIYVLGYSSLGAFKIANVRFRYDVL
>NC_016935|1641032:1714652|1676531_1677659_+|WP_014369004.1|DBSCAN-SWA
MNKYPALIFDPELRYLAQIDNYEYLQWTRRWRNPHTWELQINRNKTNTQYLQADNFIAVKRGGKWRAGIIAHRELPLTQEGKLSETWTVKGRDFSGVFLERLALHMTDTGSGYDDQRGIAEQVMRHYVNVNCIEPSNPDRVIPFLQLGLNYARGQTVEMRARFQTVAALLENLSFASGLGYETLFDLESTSFSFNVLSGRNLTPGQTEHPPVIFSPEFDNVESMAFRHSILDSKNVAIVGGKGEAQDRLVVSVANGSPKGLKRREVFIDARDLETAEQLLQRGNERLAEYGEELVMEFQHLPWGPFKYGVDFDLGDIVHARYPGVGSTESRIVGVVEELTPDKGEAVRLVVGKEWPDLVSVLKADRRNLETEVRR
>NC_016935|1641032:1714652|1700917_1701688_+|WP_014369031.1|DBSCAN-SWA
MEVAKNHFFSDLSVMLGRSMRHIFRSMDTIFTVCITPIAMMLLFVYVFGGAIQTGTDNYVNYLLPGILLMAIASGVAYVAYRLFLDKQRGIIERFHSMPIARSTVLWGHVLTSVVSNVISVVVIILVALIMGFRSSAGVLSWLAVAGILVLFTLALTWVAVIAGLSAKTVEGASAFSYPLIFLPFISSAFVPTETMPLVVRAFAENQPVTSIVETIRALLSNSPVGNDIWVALAWCLGIIIIAYLFAVRAYKRNAA
>NC_016935|1641032:1714652|1647234_1647612_-|WP_014368962.1|DBSCAN-SWA
MLDLGNRIKYLREKRAWTQKEFAAKTKLTIVQLSRYETNDRKPDPEALKRIADILETSTDYLLGRTNDPAPLPEVKDPLDDPDMDLFFYGWEKLTPERQEEVKAYVRAQLLMQEAEEREKKSKKK
>NC_016935|1641032:1714652|1666980_1667331_+|WP_014368995.1|head|DBSCAN-SWA
MNPAKYNRRIHILQPVRGEDNEGIPVITWAPIICLWAAVKPLRGREYFQAAAINQENTLRVEIRYRTGITSEMRVQYAGKLYNINAILDPDEAHRELHLMCLEVQEHGGDEAGGHG
>NC_016935|1641032:1714652|1679854_1680193_+|WP_014369008.1|DBSCAN-SWA
MTNDTKALSDQIVNVRLDIRELNTKMDGIKDLTKKVEEVHDTAKEALASTKSAHKRIDELVPVSTLVIQNEKETDRANKRLDFYDKLAFWFGTSILGSVILGGLGLWKTYKP
>NC_016935|1641032:1714652|1645882_1646653_-|WP_014368961.1|DBSCAN-SWA
MKGLIDELKKSYMNWLNEQTKITEIDGALEITSPLMDRHNDFLQFYVITNDNNKLHLTDDGYILNDLMSAGCDFKSKRRKDLLNTILAGYGVKLSEDNELISEASINNFPQKKHLFLQAMLAVNDMFMTSQTNVHNMFFEDVENFFLENNIRFSEQINLTGKSGLTHKFDFLIPRSKSRPERLISTVNSPTIDKAKSLLFAWGDSKDTRKEGTLMYTFLNDSTKTVKSDIILAFKEYDIKPVLWSNRNDVIEELSA
>NC_016935|1641032:1714652|1684059_1684926_+|WP_148279737.1|DBSCAN-SWA
MIWYYGLIVIGAIITGYTLFRKRNVVDLFTYFLFTTAWTWVGEAVVLFVFNAYAYKPGLYPDPFAENIIGHIIANSAIWASTAIWVMIFQPTYLIIGLICLLFMLIEEMFLNAGVYTQYWWHTYMTGICSFVFLAAMKKWYIILKKTKRNSPRITVFWTIAWIILQTPTSVLMLFDKQFFRVNWVENIYRDSTLFSGFLYHVLMAFIVIYFMFVPKNKYWKLAPFLILILADVILWSTGILIFYGDWKMIYLICIRAACLLYIYMLEKHSVNSVIEKASLEHKAVAKK
>NC_016935|1641032:1714652|1703862_1704690_+|WP_014369034.1|DBSCAN-SWA
MTILVTGATGTVGRHVVEQLIQKGQKVRALTRNPLQANLPNEVEVVAGDLSDPSTLVSALVGISGMHLITTGAEYTPLQTGPEIVELAEKAGVRRVTLLWNGEKGPFERAIEASSLEWTQLQAFEFMANARKWANSIRSVGVVRDMFGGSRIASVHEADIGRVAAVALTEEGHSGKIYTLTGPESLSVPDKVRIISEVIGREIQFIESSEEEEREQMRRMGVQEDAIDYVISWHLNPPKTAYKVLSTVEEVTGHKPYTFAEWVKENAGFFISDVS
>NC_016935|1641032:1714652|1670743_1671046_+|WP_014369001.1|DBSCAN-SWA
MKLVLRINGKPKTFTVSFVSGRMLRKTLEISKNTNFNNVTLEALDTLVEFVVELFEKQFTVDEFYDGIEADKLLQSVMDCIYQVTGKAAKALEPLSDPNA
>NC_016935|1641032:1714652|1654573_1654759_+|WP_014368976.1|DBSCAN-SWA
MDPIARAIIKRVIDDLETKARELQVPNIPGAGSEYVDGFKTGKAVGLFQASMELEKVLEDA
>NC_016935|1641032:1714652|1654751_1655240_+|WP_014368977.1|DBSCAN-SWA
MPRYVGIDPSTKTGFIVLDEDGEVWEARELEGMGENPERMHDLICQVGQLIQPEDRVAIEGFGFASQRGFELGGIGWAIRLNLFARQIGYTEVAPSQLKKFTGAGGTAAKEVVAVETYKRWGFQHKSNNVTDAYVLAQIVRAIHEPVKLLKVQQEVIQKLRG
>NC_016935|1641032:1714652|1649481_1649682_+|WP_014368968.1|DBSCAN-SWA
MAKGKMQVRFTAEEKQMVEKLNEEKVPAAKIAEQLNEKFHNNNPIRKAQSVYYMLKAMKKSSGTAN
>NC_016935|1641032:1714652|1710604_1711261_-|WP_014369036.1|DBSCAN-SWA
MSHKPLLVIVGSGPGVSASIAKKFGSNGFRVILISRTESSLQRSLESLRQLQIESHGITADASDPDSLKTAFKQIKDSFGTTDVLVYNAAHIVPGDPLSLTEQQLIEDFKVNTVGALTSAQQVIPDMVERKQGTLFFTGGSIALNPNPLYTSLSIGKAATRSLALSIAETVSPFGIYVGQVLIADHVKKGTYYDPDRIADVHWELYNKKDQREYLFRE
>NC_016935|1641032:1714652|1648044_1648314_+|WP_014368964.1|DBSCAN-SWA
MLKVQIDETEFQRLCRDRIADLVKEVEAELVFWDSAELKKRTCMSWNTIQELFFFDPRFPKRKIGSKWYFPARETRRFLEQWLIEQPML
>NC_016935|1641032:1714652|1658650_1659334_-|WP_014368984.1|DBSCAN-SWA
MKKKLAGLMLTLSLSFSALAVPASAKGGEIPRFPSQGVETIKATPENENDLIKKFNLKKPSPNAQLKSIRIMPATVTPPTKSGISPNFQINGYIFEETGRGTLTGSDVIAETRYFCSKVPSCKGESQLQANSSVAHQFSSTVEAALTPIISAAVGYSVTGSTGMSATLVVQEESIPTNKTWIVQGYAVHNYITFNFYKEFIGFKTKLGSGTTTKPIANRIAAVDWIQ
>NC_016935|1641032:1714652|1679680_1679824_+|WP_014369007.1|DBSCAN-SWA
MPSILYPHFEICWVKKAVTAAQLQTAVTKKYITEEEKVLIVSKEQRD
>NC_016935|1641032:1714652|1689614_1689695_+|WP_063720036.1|DBSCAN-SWA
MMWALGVVVVAVFVYLTYVLLNPEKF
>NC_016935|1641032:1714652|1648699_1648957_+|WP_014368966.1|DBSCAN-SWA
MRKQMTDSEWRGQLLAWKKSRTVIEGMDIIDKLIAESEREMELAAAKKEKTRRSGRASLRTRLKFLMLLFYHRTNVRGKGASPDA
>NC_016935|1641032:1714652|1650865_1651765_+|WP_014368970.1|DBSCAN-SWA
MAAPAKATDQKELGKALANKAAASNGQGKTIAQLFDEMKPAIAQAIPKHLTPERLLRIATTSIRTNPKLKVCTPESLLGAVMQCAQLGLEPSILGHAYLVPYRNKKKDAAGKDLGWVDEAQFQIGYKGYIELARRTGHVSSIVAQAVHEKDLFEYEYGIDEKLRHVPADGDRGPVTKYYAYAKFKDGGYSFMVMSKRDIELHRDKFSKAKTYGPWVDHFDEMAKKTVLKALMKYMPISVEFQKAVSMDETTKREVSDDMSEVIDVTDWSEAQVEEAGEERDPDTGFPTNSPPEDEVTFE
>NC_016935|1641032:1714652|1649116_1649395_+|WP_014368967.1|DBSCAN-SWA
MKKATGMTRNLDSLGRIVIPKELRMNMDLDLHDPLEIFVNGDEIILRKYTPGCSLCGQVDSPITSVYPGKKICTTCIKIIAEKAAKLNRTAT
>NC_016935|1641032:1714652|1686124_1686322_+|WP_014369017.1|DBSCAN-SWA
MRKVERNALQPGRLINVYYDLGGGEEMSVGHFREISIDILDEDSSAFIILEGINEGIMGINLECV
>NC_016935|1641032:1714652|1668689_1669088_+|WP_014368999.1|DBSCAN-SWA
MPAHSKSLYRDGAQLPAPQYFNPVTDSYEPLHGANGASDVNVKGSSAIKDGVLSVSAPGVRVQLPNIPCREVTVIARKNNIGTIYVGSETVSASSFAAELDKKDAITLPVSNASMLWIDASVAGEGISYVAL
>NC_016935|1641032:1714652|1661124_1661625_+|WP_014368988.1|terminase|DBSCAN-SWA
MAGRKAMPVNLLLIKGKKHLTKEEIELRQEREKKLQPSTNRTNPPAWLCDTAKKEFRRIAKELKEIDLLTNVDINALALYCDAYADYIEISKIIKNDGFMVEHTNKSGVTNEVAHPLLAKKKQMHEQMRSLAVEFGLTPASRAKIAMPPRGQPEEEDEFTRTFGDV
>NC_016935|1641032:1714652|1689079_1689496_+|WP_014369020.1|DBSCAN-SWA
MSLKTDGSYILVATTNKRGRAFMSVLHSMNMPYAVLTNSKQEMLELEELGIEPTVLVDTVDRSAWLVPDIPIGKVIIFEESLPLTCRYLQAVTSWTQGPIYVVSSSGMIRRMYKELGATYVIHSRNADVSFLLDISSK
>NC_016935|1641032:1714652|1655245_1655911_+|WP_014368978.1|DBSCAN-SWA
MVAAKGKANIGGITVGSKNVKIVLEVSKRDFFKNAKFFESDPEEVDFVLGDMQMSISDYLESSASSKELLASVGNSDVKQSVKDEDQVVLFDQQHQQQGSQEAQAAPNPDLEVSFEDGNIPAEGGHAADGGGHAEGKDEAEGTDESGSEPSKEEVEEHILKEQPRFDDVEFDPSLYIEKVETQSSWMDIASKYGLSSNQLQKAWGKYKNRVAEKLKQKGAA
>NC_016935|1641032:1714652|1661624_1663349_+|WP_014368989.1|terminase|DBSCAN-SWA
MLKQFLIDYSQDVINGKVIACQKHKWACMRFLRDIEREGTEEFPFIFDEERAMRFFLWMNLFRHTKGVLKGQRIEPHEIQYFIFGNIYGWIHMDTGYRRFNKAYWQVARKNAKSQSNSCVASYEASAFGESMAEVYCAATKREQAKIVWSEADYMIKQCPELKGKFKTSYGIIRHLKSNSIIKPLSQEDKKKGDGLNPQCGIIDEYHAHETDEMVNVIDSGMIARAQPLIFIITTAGTNLNSPCYRTEYQFVSRLLNPDDPTEVDSYFAMVNELDKDDDGNLIDDIKDESVWVKANPIACSYPEGIQKMRSRQKEALEKPEMMEDFMTKNMNVWMSHPKKQYMNMEKWAACGILKRRKSDPELQLPEVRGFTCFAGVDMSMKIDLSSVGFVVPLTTGSFYVGQHSFIPEETLEQKKKTDRVPYDLWIRKGWLTVIPGAVVDQSVIENYLLEEEERRGWVMREICYDRYAATQFAQNMAAHGYEIVEIRQGVQTLSEPIKDFRELVLQKRIIHEDDPVLTWALGNAVTKSDDKENLLLDKAKSTNRIDPIAAVINGFVRARVAPPDSGDVEVWTF
>NC_016935|1641032:1714652|1689727_1691398_+|WP_014369021.1|DBSCAN-SWA
MYATLSIVVTLLLVLVLARPVGLYMAQVFDYEKSKWDKWFGWIEKPIYTISGICRDNQTWKQYALAVVFSNLVMIILVYLIFRFQKFLPLNPSGIANMEPTLAFNTAISFMTNTNLQHYSGESGLSYLSQMIAIVFMMFTAPATGLAAAIAIIRALAGKPIGNFFVDLIRSITRILLPVAFVAALIFIALGVPQTLEPTVTAHTIGGEVQEIARGPVGSFLSIKELGNNGGGFFGANSAHPFENPDAISNLLQIVLMLLFGTAIPFTYGKMVGNAKQGRVLFVSMAMLFIMMLGISLVAETAGNPVLNASGIQHDQGSMEGKETRFGVIQSSFYSVVTTASETGAVNTMHDTMTPIGGLVTLANMMLNTVFGGAGVGFINVLMYTIIGVFLSGLMVGRTPEFLGKKIEGREMKLIAVTLLIQPFIILAPTALALFIYPETISNPGFHGLTQALYEFTSSAANNGSGFEGLGDNTPFWNISTGIVMYLGRFFSIVTMLAVAGSLAAKKPVPETSGTFRTDNGLFAGVFLGTVLIVGALTFFPALVLGPIAEQLTLKP
>NC_016935|1641032:1714652|1667299_1667689_+|WP_014368996.1|DBSCAN-SWA
MAEMKLEGMDELVKRLQEMGRKGAAIERAALQAGGEVIRSAASERAPRSNDAPHLADNIKISKIKTSQGMKYVLVGPQKGDNSEFFYGKFLEWGTSKMAARPFLGPVAAEKQGEVIEKMKQAIKDGLGL
>NC_016935|1641032:1714652|1644156_1645311_-|WP_014368959.1|integrase|DBSCAN-SWA
MAYYRKRGDTWEYRIKYVERQTGKQKEKTKGGFRTKKEAQHAAMEEASKINHFGFSENGSEKIDKFFEEWLETYKKPTVKPVTYSVQERNVRLNILPRWGKYRLKDITRNEYQKWINELKERYSEGTVRRIHSIFSSAMTDAVHEFNIIRENPVQKIKIPRDVETTEKVQYFTREQLDTFLDAVKEPVKHAKYQASIQYFALFTLLSRTGIRIGEALALTWDDINMDSSTITVNKTLVYPLNSAPYLSTPKSKMSNREIKLDEYTLKVLKRHKVNQKEVILQYVNYKPAKDNIVFHQHDGRWLRTNVVRDYFKAVCKRANLPVLSPHALRHSHAVHLLEAGANIKYVSERLGHASVKITADTYLHVTKKIEDDALALYEKYIQK
>NC_016935|1641032:1714652|1666793_1667000_+|WP_081484308.1|DBSCAN-SWA
MVYRVLVEFIDRDQRYYPVGDEYKTKDQDRAGYLVELGFLEAPAAAPNPPAQPEGQTGTTVTDESGQV
>NC_016935|1641032:1714652|1654412_1654574_+|WP_014368975.1|DBSCAN-SWA
MRNVDDPLFQTIHRFVIYNGKDQLGGVYVLSERFIFAPKKARHGLRCVKVVGY
>NC_016935|1641032:1714652|1705254_1706052_+|WP_014369035.1|DBSCAN-SWA
MSNVNAPFRARIGLLNDGPLTFDQLSTVLERTAFAVPFENFAIIESRTQTISKEQLLDKITVQGEGGLCYELNTLFYFFMLDNGLDARLVSGVVYNHEKQRYPATGRTHVTILLRHENRTYLIDTGFGSNLPLRPLPLSGEPVSSSNGDFRIVPAYGEHAELGDYVLEMKLKHKHSEWMTGYVFDTAKTITDDTELNAIQRIIAEHSDSPFNKKPLVTKVTERGTITLTPSFFTEWCDGVMTKTPVDESSYRELLWRYFGMRRPR
>NC_016935|1641032:1714652|1701707_1702271_-|WP_148279669.1|transposase|DBSCAN-SWA
MTAQYEAVKRWQIPIQETARILEPALVKADQSSETVRWEMGCLLSWMQQTYTRTEDTPLLTNFQSYTEGFWKGLFTCYDTPNIPRTNNDHERFFRQTKTKHRRTTGRRSWNEHILRSGEFVVLVDDALKQKNLLHRLRSVPYDTFYRERSRWKERLTETTKRRRFRRNPAAYLRQTEAKLCKWIGQP
>NC_016935|1641032:1714652|1685051_1685525_+|WP_014369015.1|DBSCAN-SWA
MGFAFFFFVAWLTIAGFGFMRKQLTFVENTVLLLLIMIISIHWSWIIFEELKHVEISKEPINYTTFLIHRSITIPVMVVIAINLVKRAATITKALLTAGLSVLLHVVLVLVGRFVGITHAVHWNLIYDVVYFALLHVIAYVFLKYFHHLGQSEAERV
>NC_016935|1641032:1714652|1656811_1656958_+|WP_014368980.1|DBSCAN-SWA
MINLANKIGVLQDEKEFIVVIHGTFYGPFKNEEIGRIQDLFDEEVLRK
>NC_016935|1641032:1714652|1694134_1696453_+|WP_014369024.1|DBSCAN-SWA
MDEFRRKTPEEILKSISELQRGRLKIYVGPFSGSGKTYHMLQEGNSLKQRGIDVVICAVSTMQRKETIEQIGCLERVPSIHWVKDGVEKKDLNIEALLARNPEVVLVDGLAHRNRMEARFRTRLQDIQHLLKQGISVITTVNVYELEGYTELAQRLTGIEVDETVPADTLELADEIRLIDVTPESILARLSEGAMEATHTSLSKRDNLGKLRELALRLVAEDVNESLEEHREALGLNGPSGASERILVSTQYHWNGSIYIRRGEQIARRLNGDMLVVTFVDPKKPLSKEQTAFKRSIVKLTEKLEVSFDELPFVRRRAMPRQLVDYAIDNKVTRIVLGHSKQTTWQEWWRGSVVNTLMKLARHVDLFYMADSAEQKGERILPTSITKKADANIYKRLSGSEVKERIIRIKRGTFKIYIGAAPGVGKTYTMLKEGNILLKKGIDVVIGLLETHGRKETFEQIGDLTTIPRQVSDYRGTRLEEMNMEAIIRLNPEVVLVDELAHTNVPGSKNKKRYEDILEILEAGISVISTMNVQHVESLNDAVEQLTGVRVRETVPDRILRLADEVQLIDVAPNALQQRLRDGKIYARNKVEQALNHFFKTGNLIALRELALREIADDVDERLEAWERRDSLRGPWRREEVIFVCVTLSPRAESLIRRGFRIAHRLKADWVVHYIAVKADLPEEQQKRIMDLRELTQRLGGIFNMQVMERRRQVAVKLLEQANVNKSTQLIIGQSQMKFWERMLYGNTVKTILKYGRHMDVLVVSGFVPKER
>NC_016935|1641032:1714652|1700159_1700918_+|WP_014369030.1|DBSCAN-SWA
MGKAIEVKGLQKSYKKLHVLKGVDFEVEKGSIFALLGSNGAGKTTVVKILSTLLQPDSGTVTVNGFDIASKPDPVRQSISLTGQFAAVDEILTGRENLILIAKLRHLKNPRQVADDMLKRFGLTDAANRKASTYSGGMRRRLDIALSLVGKPQIIFLDEPTTGLDPEARIEVWKIVKELADGGTTVFLTTQYLEEAEQLADRISILHEGRIIASGTLAELKKLFPKTQVEYVEKQPTLEEIFLAIIGKKEAI
>NC_016935|1641032:1714652|1687281_1688052_-|WP_014369019.1|DBSCAN-SWA
MTMTIGLINDALVISEEDKRLEDARITGIQLFELDYESCFHARKGRLTNCRYGVLLISCGSYSGWGECIMSSDDKAFDIIRWASFLHQLKRTTIRKALEITALHRIIWGDNRTDLVQTALLDLVARRQNVSIASHIMLRARPEPVRDAWANRYGKRNSVRHIHPGDRGTVTEMITYANHLWLQGYSLEIHKDYLIGPACSALKLLSDAIEAQWRENEDAWEPASLCNLISDPVGTGFDMHTDELFRRAMAYYEVLI
>NC_016935|1641032:1714652|1681594_1681990_+|WP_014369010.1|DBSCAN-SWA
MTMEIIQPHITEIAQSVLTIAALIALAGLRQVKKKALELYKAQTTDAQREVLNKVGTEAFAHAETLYKGMGGDAKLDAAYEYASKKLGQLGVNLTPEEIKASIHKAWLDHNAKVQPAKLNDSGTSSDQKVI
>NC_016935|1641032:1714652|1707679_1709755_+|WP_013914865.1|DBSCAN-SWA
MFNKKNVIIASFFLCSSLIFLSAGPTIIKADSVITYEGTRQAAKEKADLLTNTYGTNSVQYAIIDHGSIVVSGQSGKNNEKGQNPLTKDTMYGIGSTSKMFTTVAVMQLVDQDRIDLDTPIVQYIPEFTMKDERYKQITPRMLLNHSSGLDGSSMTNAFLFEDNDTYAYDTLLKQLAGQTLKADPGAYSVYCNDGFTLAQILIERVSGMDFTFYIHRYITEPLGMANTVTPLDSPNTAKMAGLYYPTYAGQLPNETFNVIGTGGIYSTAEDLARFSQIFTGEAEEVLSGKSAAAMAQDEYKTPLWPDDADNSTEYGLGWDSVNLYPFGEYGIKALTKGGNTFLYHSSLVVLPEQNMAAAVVSSGGRSEFDELLAKEILLQALKENGTIAEFKPEKSYGVPVKANMPESVLQYSGIYGATNTTINIDITEGGVMSITSEQSPDNPAQIFEYSADGTFKSADGNVMISFVTEENGRIYLWMRQYASLPGLGQRAVSEYNAEKLQPQDLPTETKEAWIQRDGKKYYPLNEKYTSLIYLVSGTIQLNVSKQLPGYVLDKRITGPNTAVSELQIPGTSGRDLSGYTFFTLDGVEYLNIGGSILVNEDAVKPVNVAEKSIVTIPSSGYAKWYTISDKDGGKTVKVSMSSKASFAVYNAEGTCIYFSVIGTNDQVELPAGGSIVFAGDAGTKFEISAQ
>NC_016935|1641032:1714652|1651968_1652967_+|WP_014368972.1|DBSCAN-SWA
MANPQTENGYIRIANEIWDEVIRRDFSKRQKDIMHFIWRLSYGCRKKAAFIPKLVHFELCGVGKNHIKDELLYLESCKVLFWDREAKLFEVNKNYDEWQVSPVKGWDEFRFEELIALNLKESSQNGNVKVPETGTKKFPKQELSEDGENEKFPKEELPSSQNRNFSGEKVPKTGTATPDEPSPGAGSQPRKDIIKDNNKDSSSTTKVIQMNQVTGHGRHQDFSFGRIYSIYEKHFAVNGTVSEFEVQDLGFLFDDYGGEWVYEAMREAARYKVFTLAYLTKVLKGFRARGSTQKEEPLQVVGGQPIYQVAEDDPITQQLREVYQAYAANGSS
>NC_016935|1641032:1714652|1652944_1654222_+|WP_014368973.1|DBSCAN-SWA
MLQTEALEMVILGSVFEDPSLAREVMATVTIDMFRQPWNRNLYRMMAWLEKNNHPVNYTNISTYFAKDMGKIGGVDYLLKVIGSVVSVSEIRENMKLLAELDARRKLSQLIEQTRALIDDPAAGRFDEILDTFEQKALEIRPKVSQENKSGDRIRMWFENLLLRKQNPSLAFGVLTGWDPLDRMTLGFQRSNLIVIGARTSMGKSAFANEIKVRASSMGNKVADFSLEMTIEQIYNRMASTMCGIPLQAIRIGNLTDFQIGLIADKLDEFAKIPIDDSRGVTTEYITSEMRRMKRQEGLDLVVVDYLQEINETAEQNDNGGSALHRVCQKLRAAAKDCDCAVIGLSQVKQDVDSRANKRPMVSDLSGSAAIAAVADDILLLYRDEYYNPETSDKGILEVNVAKQRNGPTGIVKLKYDKDTQKITV
>NC_016935|1641032:1714652|1696530_1698060_+|WP_014369025.1|DBSCAN-SWA
MIQQRSYLWVTLSIILLTFVLNMLGPAFDLVNIALVYLLPVLISAVYGGKGASFYAAVLGVLAFDFFFVPPQLSFSVSDLRYVVSFGIFLFVASLTGGLAAKLKNQLHYSKQREAYTASLYALSKEMNAIADFQALLQHITLKVSHTVQSESVIYLPNERDELEPASYSMPVPAWAQSEAEMVIAKWVYQHGEHAGKGAGTLREASGRYIPLKIEEKIYGVLSVNLGSSAPSSDMLKLLEALGEIAASAIARVKLSEEAKLAHLTAESERLRTAILDSVSHELRTPLATVIGSATALIEGEGMFSPQDRMELLVTIRDGSLRMNRLVSNLLGMVQLESGMLRLRKRWCDVEDIIGVALKQVKDFQQHRKIRVQFLKQVPLILGDEVLLEQVLVNIISNAIKYSPDGSEINIMVNKEEDAVFFSVSDQGIGIEVSERERIFDKFYRADKSKHITGTGLGLAICKGIVELHGGTISAKPNGEKGLSIVISLPISDEDKIFFIHEEGEQAPV
>NC_016935|1641032:1714652|1649990_1650863_+|WP_014368969.1|DBSCAN-SWA
MQALKLVSVKDMPREDWLEYRRKGIGGSDVAPICELSKYKSPMAVYLDKIGELPPLEDNDKMKAGRMLEPLIAKWFTEETGIRVMQQHSIFKHREHDFMLANIDRWVIGKNEGLEIKNTSEYNRDEWAGDKVPVEYMLQCNHYMAVTGAERWYVAVLIGGWDFQWRIIERDEELIRNLIEIEYNFWHNHVLAKQPPAYGHQDTGLLKDRFPESRPGANMELGEEHSELIRLVFDSKKALKRAEETHETAKNRMKAVMGEHETAWFQGEPVFTWKSNKKGVRSFKIVGGDE
>NC_016935|1641032:1714652|1647768_1647996_+|WP_014368963.1|DBSCAN-SWA
MRKVNLRKIKQLRKEAKFSLDEMAQLLGYESPNGYYYLEIGRGKFSAEALAKVADKFGVPIDELFFIQDVTEMAN
>NC_016935|1641032:1714652|1657905_1658283_+|WP_014368983.1|DBSCAN-SWA
MSILFKMEELFPKASKADIIRTKAYLSQYKEKKRRVEMFERNPPQTDELKEIQTNLIKFTSLLERAVAQIIHDDVRKVIEYRFLKGNSRAATILRFESWECCDKTIDRKIIEGIESVANTLLYLE
>NC_016935|1641032:1714652|1659823_1660165_+|WP_014368986.1|DBSCAN-SWA
MTRKPMRPCNFPLCSELTAGNYCQTHQQQTVRLYDKARDPKLVSFYKSSSWLSTRQAVLSRDNHLCQHCLQEQRLTPAVMVHHIQEVRKDWEVRLDLDNLISLCDACHNKVHN
>NC_016935|1641032:1714652|1664603_1665308_+|WP_014368991.1|head,protease|DBSCAN-SWA
MNQKPTTTPDPNQNEVRTLKLTKLETRALGDESGTGTKITGYAAVYEEFTELRDWWGDRFYERIAKGAFDDTLADGHDIFALKNHDWNLILGRSGANLTLESHENGLYFELLPNNSSLGQDMKEDVRSGLIKGCSFGFRIVDQEWEQRDDDWFRTIKKVELQEITLTPIPAYSSTTAEVRSLDRQGQHKTALEVPDSQRFSVPKGLSEEQIRALKRKNEALLLDIETTLRYGRA
>NC_016935|1641032:1714652|1666492_1666804_+|WP_014368993.1|head,tail|DBSCAN-SWA
MLSLDLDELKTYLRVDGSENDGFLALLVHSAKEYLKDAGVPESSSARYKLAVMIQVALNYDRDGNAALEKALESLINQLRVGEPKHGGSEPENLLEGTCGDGI
>NC_016935|1641032:1714652|1657177_1657507_-|WP_014368981.1|DBSCAN-SWA
MTLDKATLFAYISLAIFILALLLMPKRLNRKEIYTTWFVMACLTLNTDLIFGLILDLYDFIYPDITLSDLILQAALPPAAGILALNFQPQKNSQFLVLSYTRSLLFSFI
>NC_016935|1641032:1714652|1642245_1642677_+|WP_014368958.1|DBSCAN-SWA
MSQLDDLYRRVIMDHYKNPRNRGTFDEGEAVSINLNNPTCGDKIQLQMQVEDGRVKAAKFVGEGCSISLSSASMMTDAVKGKTLEEALEMAENFSGLMKGESVEFEYEDIESLSGVNKFPARIKCATLAWNALRKGIEQSKTQ
>NC_016935|1641032:1714652|1667685_1668048_+|WP_041619061.1|DBSCAN-SWA
MINVKPEVLESLREDEELLLLLGGPRVYQLVAPEPGKFPRITFFEVSNVDDSYADDSAISSQIVIQVDVWNKTNTSAIADRVDAVMKNIGFSRSGSADLYENDTGIFHKAMRYTTRREEV

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014368957.1|1641032_1642259_+	cysteine desulfurase	Q2XUY6	environmental_halophage	8.7e-113	45.7
WP_014368958.1|1642245_1642677_+	SUF system NifU family Fe-S cluster assembly protein	A0A2H4N7M4	Lake_Baikal_phage	4.4e-11	44.6
WP_013914840.1|1642695_1644093_+	Fe-S cluster assembly protein SufB	NA	NA	NA	NA
1644133:1644154	attL	NA	NA	NA	NA
WP_014368959.1|1644156_1645311_-|integrase	site-specific integrase	S5MBZ0	Brevibacillus_phage	2.5e-170	75.7
WP_014368960.1|1645264_1645807_-	ImmA/IrrE family metallo-endopeptidase	NA	NA	NA	NA
WP_014368961.1|1645882_1646653_-	DUF1829 domain-containing protein	Q6SEA4	Lactobacillus_prophage	2.9e-37	37.5
WP_187297997.1|1646678_1647128_-	hypothetical protein	Q4ZCB9	Staphylococcus_virus	2.8e-08	41.2
WP_014368962.1|1647234_1647612_-	helix-turn-helix transcriptional regulator	A0A1L2JY18	Aeribacillus_phage	1.1e-13	52.1
WP_014368963.1|1647768_1647996_+	helix-turn-helix transcriptional regulator	A0A1L2JY14	Aeribacillus_phage	2.7e-20	70.3
WP_014368964.1|1648044_1648314_+	hypothetical protein	A0A1B1P7U4	Bacillus_phage	2.7e-27	59.3
WP_014368965.1|1648470_1648707_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_014368966.1|1648699_1648957_+	hypothetical protein	NA	NA	NA	NA
WP_014368967.1|1649116_1649395_+	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	A0A0K2CZ86	Paenibacillus_phage	1.4e-15	45.5
WP_014368968.1|1649481_1649682_+	hypothetical protein	NA	NA	NA	NA
WP_148279666.1|1649812_1650004_+	hypothetical protein	NA	NA	NA	NA
WP_014368969.1|1649990_1650863_+	YqaJ viral recombinase family protein	S6C475	Thermus_phage	4.6e-68	46.8
WP_014368970.1|1650865_1651765_+	recombination protein RecT	W8EBF6	Geobacillus_phage	1.1e-69	54.6
WP_014368972.1|1651968_1652967_+	replication protein	W8EKA2	Geobacillus_phage	2.4e-36	56.8
WP_014368973.1|1652944_1654222_+	AAA family ATPase	I6S783	Marinomonas_phage	1.1e-44	30.4
WP_014368975.1|1654412_1654574_+	hypothetical protein	NA	NA	NA	NA
WP_014368976.1|1654573_1654759_+	hypothetical protein	NA	NA	NA	NA
WP_014368977.1|1654751_1655240_+	crossover junction endodeoxyribonuclease RuvC	A0A0C5AFC9	Paenibacillus_phage	4.8e-30	47.6
WP_014368978.1|1655245_1655911_+	hypothetical protein	NA	NA	NA	NA
WP_014368980.1|1656811_1656958_+	hypothetical protein	NA	NA	NA	NA
WP_014368981.1|1657177_1657507_-	hypothetical protein	NA	NA	NA	NA
WP_014368983.1|1657905_1658283_+	hypothetical protein	NA	NA	NA	NA
WP_014368984.1|1658650_1659334_-	hypothetical protein	NA	NA	NA	NA
WP_014368985.1|1659480_1659717_+	hypothetical protein	NA	NA	NA	NA
WP_014368986.1|1659823_1660165_+	HNH endonuclease	A0A1U7Q1S7	Geobacillus_virus	9.4e-25	48.3
WP_041619058.1|1660281_1660905_+	hypothetical protein	NA	NA	NA	NA
WP_014368988.1|1661124_1661625_+|terminase	phage terminase small subunit P27 family	A0A2H4J8E3	uncultured_Caudovirales_phage	1.1e-45	59.7
WP_014368989.1|1661624_1663349_+|terminase	terminase large subunit	A0A0S2GLF0	Bacillus_phage	4.3e-174	53.1
WP_014368990.1|1663381_1664647_+|portal	phage portal protein	A0A0U3SQF0	Bacillus_phage	9.0e-81	46.1
WP_014368991.1|1664603_1665308_+|head,protease	HK97 family phage prohead protease	E2ELI4	Clostridium_phage	2.4e-35	50.9
WP_014368992.1|1665309_1666476_+|capsid	phage major capsid protein	A0A1B1P7R4	Bacillus_phage	2.7e-100	49.6
WP_014368993.1|1666492_1666804_+|head,tail	phage gp6-like head-tail connector protein	NA	NA	NA	NA
WP_081484308.1|1666793_1667000_+	hypothetical protein	NA	NA	NA	NA
WP_014368995.1|1666980_1667331_+|head	phage head closure protein	A6M954	Geobacillus_virus	7.4e-17	36.9
WP_014368996.1|1667299_1667689_+	HK97 gp10 family phage protein	W8CZ44	Bacillus_phage	5.0e-22	44.4
WP_041619061.1|1667685_1668048_+	DUF3168 domain-containing protein	Q2I8F3	Bacillus_phage	5.6e-28	53.1
WP_014368998.1|1668051_1668666_+|tail	tail protein	A0A2H4J8F3	uncultured_Caudovirales_phage	2.1e-35	41.5
WP_014368999.1|1668689_1669088_+	hypothetical protein	A0A0S2SXM1	Bacillus_phage	6.6e-22	43.9
WP_014369000.1|1669074_1670688_+	fibronectin type III domain-containing protein	A0A2D1GD28	Mycobacterium_phage	8.4e-07	46.5
WP_014369001.1|1670743_1671046_+	hypothetical protein	A0A0S2SXQ2	Bacillus_phage	6.4e-09	45.7
WP_014369002.1|1671242_1675685_+|tail	phage tail tape measure protein	A0A0S2SXL7	Bacillus_phage	1.4e-75	35.4
WP_014369003.1|1675677_1676529_+|tail	phage tail family protein	A0A2I7SBZ7	Paenibacillus_phage	6.8e-40	32.6
WP_014369004.1|1676531_1677659_+	siphovirus ReqiPepy6 Gp37-like family protein	A0A0K2CZQ1	Paenibacillus_phage	1.1e-50	32.6
WP_014369005.1|1677660_1679373_+	hypothetical protein	NA	NA	NA	NA
WP_014369006.1|1679384_1679660_+	hypothetical protein	NA	NA	NA	NA
WP_014369007.1|1679680_1679824_+	hypothetical protein	NA	NA	NA	NA
WP_014369008.1|1679854_1680193_+	hypothetical protein	NA	NA	NA	NA
WP_014369010.1|1681594_1681990_+	hypothetical protein	NA	NA	NA	NA
WP_014369012.1|1682264_1682900_-	hypothetical protein	NA	NA	NA	NA
WP_014369013.1|1683385_1683952_+	cupin domain-containing protein	NA	NA	NA	NA
WP_148279737.1|1684059_1684926_+	hypothetical protein	NA	NA	NA	NA
WP_014369015.1|1685051_1685525_+	hypothetical protein	NA	NA	NA	NA
WP_014369016.1|1685521_1686067_+	hypothetical protein	NA	NA	NA	NA
WP_014369017.1|1686124_1686322_+	hypothetical protein	NA	NA	NA	NA
WP_014369019.1|1687281_1688052_-	hypothetical protein	NA	NA	NA	NA
WP_014369020.1|1689079_1689496_+	hypothetical protein	NA	NA	NA	NA
WP_148279668.1|1689510_1689618_+	signal peptide protein	NA	NA	NA	NA
WP_063720036.1|1689614_1689695_+	K(+)-transporting ATPase subunit F	NA	NA	NA	NA
WP_014369021.1|1689727_1691398_+	potassium-transporting ATPase subunit A	NA	NA	NA	NA
WP_014369022.1|1691429_1693460_+	potassium-transporting ATPase subunit KdpB	M1HBF8	Paramecium_bursaria_Chlorella_virus	2.1e-26	25.6
WP_014369023.1|1693479_1694049_+	potassium-transporting ATPase subunit KdpC	NA	NA	NA	NA
WP_014369024.1|1694134_1696453_+	histidine kinase	NA	NA	NA	NA
WP_014369025.1|1696530_1698060_+	DUF4118 domain-containing protein	A0A1V0SGX0	Hokovirus	8.8e-14	28.7
WP_014369026.1|1698056_1698758_+	response regulator	NA	NA	NA	NA
WP_014369027.1|1699108_1699438_+	PadR family transcriptional regulator	NA	NA	NA	NA
WP_014369029.1|1699796_1700120_+	DUF1048 domain-containing protein	NA	NA	NA	NA
WP_014369030.1|1700159_1700918_+	ATP-binding cassette domain-containing protein	W6JKT0	Anomala_cuprea_entomopoxvirus	9.0e-28	32.7
WP_014369031.1|1700917_1701688_+	ABC transporter permease	NA	NA	NA	NA
WP_148279669.1|1701707_1702271_-|transposase	transposase	NA	NA	NA	NA
WP_014369033.1|1703482_1703866_+	MerR family transcriptional regulator	NA	NA	NA	NA
WP_014369034.1|1703862_1704690_+	NmrA family NAD(P)-binding protein	NA	NA	NA	NA
WP_014369035.1|1705254_1706052_+	arylamine N-acetyltransferase	NA	NA	NA	NA
WP_013914865.1|1707679_1709755_+	serine hydrolase	A0A023ZXL4	Mycobacterium_phage	3.2e-06	23.0
1706516:1706537	attR	NA	NA	NA	NA
WP_014369036.1|1710604_1711261_-	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_014368330.1|1713096_1713774_+	helix-turn-helix domain-containing protein	A0A0C5AJ29	Paenibacillus_phage	4.9e-41	43.0
WP_014368331.1|1713944_1714652_+|transposase	IS3 family transposase	A0A0C5AEA5	Paenibacillus_phage	1.9e-75	59.7

Sequences of DBSCAN-SWA_2

Nucleotide sequences of DBSCAN-SWA_2

>NC_016935|3407286:3417726|DBSCAN-SWA
CATGGCTAAACAAGCGATTATCAAGATGGCAGACGGCAACGAAATCGTACTCGACCTGTTCGAGAATGACGCACCGAACACGGTGGCCAACTTCGAGAAGCTGGCGAACTCCGGCTTCTATAACGGCATTCCGTTCCACCGCGTCATTCCGGGCTTTGTAGCTCAAGGCGGCTGCCCACACGGTACCGGTACAGGCGGTCCCGGCTATACGATCAACTGCGAGATCAACCCGAACAAGCATGAGCGCGGAACGCTGGCCATGGCTCACGCCGGCCGCAACACGGGCGGAAGCCAGTTCTACATCTGCTACGCGCCGCAGCCTCATCTTGACGGCCAGCACACGGTGTTCGGCAAAGTCGTGAAGGGCATGGAGCATGTGGACGCGTTCAAGGGACGCGAGAAGATGGAAACCGTGCAGGTCGTGGAAGCGTAAGCTTGCGGCTCAGCAGTTAATTTCAATAGCTTGAACCTTCGGGGCAGGGTGAAATTCCCTACCGGCGGTGATGGACGGCTCACGAGTTGAGCCGCCCTCAGTCCGTGACCCGCGCATCTTCATTTCCTGGCGGAAAGGAAGATGCCGGTGGACTCGGTGCAATTCCGAGACCGACAGTATAGTCTGGATGGGAGAAGGGGAAGCGAAACGGATCGAATGTCCGGTCCGGGAAGAGCAAGCCAGGCGGGCGAGTCCCGTTCGAGCCTTGCTGTCCGCTGACGTGCGTTCATGACGCATCGTCTGTTCGGGCGCAGGCAGGAACAGGGAGCGGTGTGTCCGGCGGAGCTCTTGCCGTGATCGGGAGTAGCTTAATCCAAGCTTTCACATGCGACTACGGGTGTTTTACCCGGAAGGCGCGTGTACTTTCGCACATCCGATTTCGCTCTACCGCGATTCCTTTGGCCCCTTTTTGCTTCGGCAAACAGGGGCCTTTGTGCGTTTACCGGGAAGAATACCGGAGTAGGCGCGGAGCGGCCGAACGGGATGAACCGAAGCCCGGCGGCTGCTCCCGCAGGAACGACGGGGGAGGAGTGGAATGGGATGATCATCAATGACGAGATGTATATGCGGATTGCTCTTCAGCTGGCTGCCGCAGCCGCCGGCCAAACCGGCATCAACCCGGTCGTAGGCTGCGTGCTCGTCAAGGACGGGCGTGTGGTCGGTATGGGGGCCCATCTCAAGCGCGGCGATGCGCATGCCGAGATCCACGCGCTGAACATGGCCGGAGCCGAAGCGGCGGGCAGCACGGCCTACGTGACCCTGGAGCCCTGCAGCCATCACGGCCGTACCGGCCCCTGCAGCGACCGGCTGATCCGCGAAGGCGTCAAGCGGGTCGTCGTTGCCGCGGTGGACCCGAACCCCGTGGTGGCCGGCAGCGGCATCGCCCGGCTGCGGGCCCAGGGCATCGAGGTCACCGAAGGCGTGCTGGCGGCGGAGTCGGAGGCGCTCAACGAAGCGTTCAACAAATATATTGTGACGCGGAGGCCGTTCGTTACGGTGAAGACGGCGAGCACGCTGGACGGCAAAGTGGCCGCGGCGGGCGGCGACAGCAAGTGGATCACCGGGGAAGCCGCACGGGGCTACGTGCATACGCTGCGGCACCGCCACCAGGCGATCCTCACGGGCGTCGGCACGGTGATGGCCGATGATCCGCAGCTGACGACCCGGCTTCCGGTGCCCGGGCTCTCGCCGGTCCGCATCATCGCGGACTCGATGCTGCGGATCCCGCTGGAGTCGAAGCTGCTGCATGACGGCGAGGCGCCCGTGATCGTGCTCACGACGGCGGAGGCCCCGGAGGACCGCCGGCGTGCGCTGGAGGCGCTCGGCGTGCAGGTCATTGACTGCGGCCCGGGACCTGCGGTCGATCTCGAAGCCGCCCTCGCACGGCTCGGGGAGCTGGAGATCGGCTCCGTACTCGTGGAGGCGGGCGGCAAGCTGGCCGGCGCCTTCCTGGAGCGGCGGCTGGCCGACAAGCTTGTGCTGTTCTTCGCACCGAAGATTATCGGCGGCGGGGCGGAGGCCCCCGGCACGTTCGATTTCCCGGGGTTCCGTGCGATGCGGCAGGCGATTCGTCTTGAACGGATGACCGTAGAGACCTTCGGGGAGGATGTCTGCTTCACGGGATACCCCAGCTATGAGGCTGCCGACAGCTAGCTTGAAGCTGGCACGGCGGCGAAAGGAAGGAATCAACCATGTTTACTGGCATTATTGAAGAAATCGGTACGCTGCGGCGGATCGCCAGACAGGGGGAGGCCATGGTGCTGACCATCGGGGCAAGCCGCGTGCTGGAGGATGTGAAGCTCGGCGACAGCATCTCCGTCAATGGGGTCTGCTTAACGGTCGTGTCTTACGACAAGGAGTCGTTCACGGTCGACGTGATGCCGGAGACCTTCCGCCGGACGAACCTCGAGCGCCTGTCCTCCGGCTCGCCCCTCAACCTGGAGCGTGCGATGGCGGCCAACGGGCGGTTCGGCGGCCATATCGTGCAGGGCCATGTCGATTCAACCGGCACAATCGTGGGCCGCACCGCGGAGGCAAACGCCGTGGTGTTCCGTGTCTCGCCGAAGGACCCCGGCCTGCTCAAATATGTGCTGCCGCACGGCTCGATCACGATCGACGGAATCTCCCTGACCGTCGTAGAGGCGGACAACGCGGAATTCACGGTCTCGATCATTCCCCATACCCTGGCCGAGACCGTGCTGCAGCATAAGAAGCCCGGCGACGAAGTGAATCTCGAAGCGGACGTGCTCGGCAAGTATATCGAGCGGCTGCTTGGGTTCCAGGGAGGACAGGGGGGTTCCATGTCCCGTGCCCGCGGCCGGCTGACTGCCGATTTTTTGAGCGACAACGGGTTCCTCTAAAGGAGCCGGTACAAAGAGCAGGGCAGGAGACGGAGAGAACCGTACTGAAGGAGGGCGAGAGCTTATGTCGGAAGCAAATCAAGAAGGAAAGTCCCCGGAGCTCCGGTTTCATACCATTGAGGAGGCCTTGGCCGATCTGAATGAGGGGCGGGTCATTATCGTCGTCGACGACGAAGACCGCGAGAACGAGGGGGACTTTGTGGCGCTGGCCGAGAAATCCACGCCCGAAGTTATCAATTTCATGATTAAAGAAGGCCGCGGCCTGGTGTGCGTGCCGATTACCGAGGAACGGGCGCAGGAGCTCGATCTTCCGCCGATGGTCGCCCGCAATACCGATTACCACGGTACGGCGTTCACCGTATCGGTGGACGCGGTGGAGACGACCACCGGCATCTCGGCGGCGGAGCGCTCGCGTACCGTGCAGGCGCTGATCGACCCGGCGACGAAGCCCCATGCCTTCCGCCGTCCGGGCCACATGTTCCCGCTGGTGGCACGCAAGGGGGGCGTCCTGCGCCGTGCCGGCCACACGGAGGCGGCCGTGGATCTGGCCCGCCTGTGCGGGTCGTATCCGGCAGGCGTCATCTGCGAGGTGATCAAGGAAGACGGCGAGATGGCCCGTGTTCCCGAGCTGATGGAGATTGCGAAGAAGCATGACCTCAAGATCATTACGATCCAGGATCTGATCGCCTACCGCAACCGCATGGAGAAGCTCGTCCAGCGCGAGGTGGAAGTGCGCATGCCGACCGACTTCGGCGTCTTCACGGCCGTAGCCTACACGAACGATGTGGACGGCAAGGAGCATGTCGCCCTGGTCAAGGGCGGTATCGACAGCAGCCGTCCTACACTGGTGCGCGTGCATTCGGAGTGCCTTACCGGCGACGTATTCCACTCCCACCGCTGCGACTGCGGACCGCAGCTGGCCGCCGCGCTGAAGCAGATCGACGAGGCTGGCGAAGGCGTGCTGCTCTACATGCGCCAGGAAGGGCGCGGAATCGGTCTGATCAACAAGCTAAAAGCCTACAAGCTGCAGGAGACGGGGCTTGACACGGTGGACGCGAACCTGCAGCTCGGCTTCGCGGCGGATCTGCGGGATTACGGCATCGGGGCGCAGATCCTGAGAGATCTCGGCGTCGGCCAGATCCGCCTCATGACGAACAACCCGCGCAAGATCCGCGGACTTGAGGGCTACGGCCTGCAGGTGGTTGAGCGGGTGCCGCTGCAGATGCAGGAGAATGAGGACAATACGGGCTATCTGCATACGAAGCGCAGCAAGCTCGGGCATTTGCTTGAATTTAACATCTAAAAATTTGTTCAATCATGGAAGGGAAGTTGAAGACATATGGCGAAAGTATACGAAGGACATTTGGTATCTCAGGGACTGCGTTACGGTATTGTGGTAGGAAGGTTCAACGAATTCATTACGAATAAGCTGCTCGGCGGCGCGCTCGATGCGCTGAAGCGTCACGGCGTGCAGGAAGACGAGATTGAGATTGCCTGGGTGCCGGGCGCCTTTGAAATTCCGCTGATCACCCAGAAGATGGCTGAGAGCGGCCGGTACGATGCGGTGATTACCCTCGGTGCGGTGATCCGCGGGAGCACGCCTCACTTTGACTATGTGTGCAGCGAAGCGGCCAAAGGCGTGGCGGCCATCGCGCTGAAGACGGGCGTGCCTACGATCTTCGGCGTGCTGACGACCGATTCCATCGAACAGGCGGTTGAGCGTGCGGGCACGAAGGCCGGCAACAAGGGCTGGGAAGCCGCGGCAAGCGCCATCGAGATGGCCAACCTCTCCAAGCAATTCGCGAAGTAACGAAGCCACAGTTCCTGGGCAGTAAGGGGGAACAGACCACAAGTGAAAGTCACGGTAAAGCTGGAAACCTTCGAGGGCCCCCTTGATTTGCTGCTTCACTTGATAGATCAGGCGGAAGTCGATATCTACGACATTCCGATTAAGGACATTACCGATCAGTATATGGAATACCTTGGGGCGATGCAGGAGCTGGAGCTCGAGGTCACGAGCGAGTTTCTCGTCATGGCCGCGACCCTGCTCTCCATCAAGAGCAAGATGCTCCTGCCGAAGCCGCCGGTGCTCGATCTCGAGTTCGACGATTACATGCAGGACGAGGATTACGATCCCCGGGCCGAGCTCGTCGCAAAGCTCATTGAGTACCGCAAATACAAGGCGATCGCGGAACACCTCCGGGACAAGGAGTCCGAGCGCAGCCTGATCTATACGCGGGAGCCGGAGGACCTGACGCCTTACACTCCGGTGAAGCCGGAGAATCCGGTGGAAGGGCTCCATGTCGCCGATCTCGTGCGCGCCTTCCGGAAGGCGCTCCGGCGCATGGAGAGCCGGAGCAGTGTGGCGCGCATCCGCAAGGATGAGATCTCCGTGAAGGACCGGATGTTCCAGGTCGTTGACCTGCTCGCCCGCGAGCGCGGCCCTGTATTTTTCTCCAGGCTGCTGGAGCAGGAGGCGTCCAAGGATTCCATCGTAGTGACCTTCCTGGCTCTTCTGGAGCTCATGAAGGTGAAGAAGATTACGTGCTATCAGCACAAGCTGTTTGACGACATTGTGATACAGGCAAGAGAGGATGGAGCAGCGAATGGATTCTGGGCAGATGAAATCAGTTATTGAAGGCTTGCTGTTTGTGGCGGGGGACGAAGGACTGAGCGCCAAGCAGCTGGCTGAAGTGCTGGAACATGATGCCGCTTTTGTGAAGGAGCTGGTGAAGGACCTGCAGAAGGATCTGAAACGGACCCAGAGGGGCATCCAGATTGTGGAGCTCGCCGGGACATTTCAGCTGACGACGGTTCCGGACCATGCCCCTTACTTCGAGCGGCTGGCCCACTCACCCTCCCGTTCCTCCCTCTCTCAAGCCGCGCTGGAGACGCTGGCCATCGTGGCCTACAAGCAGCCGATCACGAGAGTCGAGATTGAGGAGATCCGCGGCGTCAAGGCAGAGAAGGCCCTTCAGACCCTGGTATCGAAGGATCTGATTCAGGAGGTCGACCGGGCGGATGCGCCGGGCCGGCCGATCCTGTACGGAACGACCAAAGCGTTCCTCGATTACTTTGCCCTCGGATCGATCGACGATCTGCCCGAGACCACGCTCTTCGAAGACGATGAGAATCTGGAGGAAGAAACACGCCTCCTGTTCGAGAAGCTTGAAGGCCAGCAGATTACGTTCGACGAGCTGGCATTGGGCCAGGAATCGCGCTAGGCGCATGCGTTTGGCAGATTAGGGTCACAATAACTCCTGTGGAAAAGAAGCGGACGCTTCTTGGTACCGGGAGTTTTTTTGTCGTATGCGTACTGTTTGCGGCAGGGGAGGAACGAATACCGATGATATGGGCTTGGGCAGCCGCAGGCCTGGCGGCCATCGCGATCGCGGCTTTGGTGCTGAGTCAGGTGACGATACAGATTGGTTTCAGCCAAAAAGGCAAGGATGAAGACATCACCGTCAATGCGAAGGCGCTGTTCGGCTTGGTGAAGCTGAAATTCGAGATTCCCTTCATCCGGTTTAAGAACCTGCAGGAAGGGTTTGAAGTGAAGGCAAAGGCCAAGCAGGTGAATTCAACCGCCGGGCAGCTCCTTGGCCAGGCGATGGAGAATATCGGACCGGAGATGCTGAGGAAGGCTTACGAGAACATCCGGAAGCTCCTCGAGAACACCTTGAATTTCAACGAGTGGCTGCGTCATATGCTCGGCCGTGTCCGATGCACGCAGATGGATTGGAAGACGACGGTCGGCATCGGGGATGCGGCGGAGACCGCTTTTCTCGCAGGAGCGTTTTGGGGGATCAAAACCTCGATTCTCGGGCTCTTGTTCCGCTACATTCCGCTGGAAGGACAGCCGCGGCTCGCGGTGGTGCCGGCATTTAACCAGACTCTGATAGCGGTGGAAGTGATGTGCACGTTCCGGATCCGGATGGCTTATATCCTTCTGTCCGGCGTGCAGCTGCTTTGGAGAGTGTTGAAGGTCAAGGGAGGCCTCAAGGCTTGGCGGAACGTGCTGCTGCCATCGTAAGTCGATGGATCGGTCCCGCCCCGGCTGTCTGCGCCCGAGGCGGCTTACGGCCTTGAGGCCCTTCGCAATGGAATACGGCCGAAGCATCAAGGGAAGCCTAACGAATGGCTAGTCAGTCTACACAACTTCTGATCAGGAGGGAACAGCGATGACAGAACATCCGATTCAAGGTCTTATGAAAACGGCCATGGAGAATATCAAGGAAATGGTCGACGTGAATACGATTGTCGGTGATCCCGTAGAGACACCGGACGGCAGCGTAATTATGCCGATCAGTAAGGTAGGCTTCGGTTTTGCGGCAGGGGGCAGCGAGTTCGTAACCACGGAAGAGGCTAACCCTCCGGGGCTTACCCGCCACGAATCCCACAATGCCCAGGTCGCTCTTCCGTTTGGCGGCGGCAGCGGCGGCGGCGTGTCCATTACGCCGATCGCTTTTCTCGTTGTAGGCAAGCAGGGCGTAAAGATCGTACCGCTCGATAACCAGACGCATCTGCTGGAGCGCCTGATCGATTCCGCCCCTCAGGTGGTGGACCGCATTCAATCCATGATGAAGAGCGGCGGCGGCGGCAAGTCGCAGGGCTCCGAGCAGAGCTCTTCCGCAAATGCCGGTGCGACGACGGTGACGAATAACATCGAGAATCAGAACTTTATCGTGTAGCTCCATTTCTTTTCATTTAAGCAGACGGCCAAGCTGCTCTCCTTGCGGGAGCGGCTTTATGCATTTAGGATGTCATAAAACTTTCCATCTGGTTCCAAAGATCTATAAAAATATTGAAATTATAGGATAAAAGAGATAGACTAACCCCGGCCTTCATGCTACTATAGGTAACAAAGAACTATACATACCTGATTACGATAAAGGCAAACTCATCGAAAGGTGGGGACGCAAAGCCACAGATCTAAAGCCTTCAGTCCCGCTGACAGGCAATGACCGCTGGGTTACCGAAAAGATACCGTACTTTCCGGTGATAGGCTCAGATCGACGGCTGCTCTTGCTGAAGGGTGGCTTTTTTGATTTTGGTTCGGATCCCCGCAAGGACCCTCTTCCGACAATTCAGGCCGCCTCATCCTACCCGTTATGGAGGGCTCATCATGTCTGGAACTTATAATGTCTATCTCGTTCTCCTCTCGTATCTCATCGCTTTTATGTCGGCCTATTCGGCCTTTGATCTGGCGCGCCGGCTCTCCGCCGCCGCGGCCCGCGTTCGCAGGCTCTGCCTCGGCCTGGCGGGCGTGATTCTCGGCATCGGCATCTGGGCCATGCACTTCGTAGCCATCCTGGCTTATGAAACTTCTCTGTCTATTCATTATGACAGCTTGCTGATGCTTCTTTCCGTCGGTTTTGCCGTTACGGCCTCCTGGGCCGGACTGGCTGGCGCCAGCCGTCCCGCTCCCGGCCTCCGGCGTCTGCTCGCCAGCGGATGTATCGTATTCGCCGGCGTAGTGGGGATGCACTTCATCGGCATGGCGGCCATGGGGATGGGCGGTGATCGTTACCACTGGCTTCTGCTTATGCTGGGGGCGGCAATCGGACTTGCCGGATCGTTCGGTGCGTTGTTCGTGTCCTTCCGTTCGCAGCCTGCGGGAGGCAGGAACTCCTATCTGCGCCGGCTGCTCGGTGCCGCCATGATGGGCGGGGCGATTGCCGGCCTGCATTACCTGAGTATGGAGGCCATGACGTTCGGGTCCGTCGGACACCTCCATCAGAGGTTCCGCCACGCCGGCCATCAGGATGAAATGCTTGGTATTATCCTGGCGAACTGCATCATTTTTCTGCTAAGTATCATCGTGATTCGGGGCTATTTCCTGGACCGGAGGTACCGGGAAGGCGAGGCCTTCCGACTGGCGGTGCTGGAGTCGGCGCTGGACGGCATCCTCCTGGTGGATCACCAGGGCGGCATTATGGAGTGCAATCCGGTGATGGGCGGAATGTTCGGGTACCCCCGCGAAGAGCTTGCTACCCTGCACCTGACCGATCTTCTTGAAGTTCCGGCAGGAGGCAGCGGGGACGGTGGGCTGAGCACGGAAGCGGAAGGGCGGGAGGGGCCGTCCGGCTTCGCACTGCCCGTGGAAGCGATCCGCGGGCTGCTGGACAGCCGCGTCGAGACGACGGGATGGCGTGCCGACGGCACGGCCTTCCCGGTGGAGATCAGCCTGACCCGGACTGAGGGCTTCGGCCGTCCGGTCTTCACCGTCTTCGTCCGGGATATTACCGACCGCAGAAAGGCGGAGGAGCACATCCGGCAGATGGCGCTGCGCGACCCGCTGACGGGGCTCTACAACCGCTCCTACCTTCAGGAAAAGCTCTCCTCCGCGCTGAGCCGCGCGGAAGGAAGCCGGGGGACGATTGGGGTGATGTTCCTCGATCTGGATGGCTTCAAGTCGATCAACGATACCTTCGGCCATGACTCGGGGGATATGCTGCTTCAGGAAGTGGGCGAGCGGCTGCTGCACTGCGTCCGTGAAGAGGATTTGGTGTCCCGGCAGGGCGGCGATGAGTTTATCGTCATGCTCAGCGGAGTGACCCCGGGAACAGCTTCGAGCATTGCCGTGCGGATGATTGAGGCGCTGGCCCGGCCTTTTTATTACGCCGGCAGGGAGATGACGGTGACGCCGAGCATCGGTATTGCGCTTTATCCCTCCGCCGGTACGAGTGCCCATGTGCTGGTGAAGCATGCGGATGCGGCGATGTACCAGGCCAAGCTGAACGGGAAGAACCATTTTCAATTCTATACGGCCGAGATGGAGGCGTCCCTCTCGCAGCAGACGAAGCTGGAGGCCCGGCTCAAGCTTGCCCTGCAGCAGGACGAATTCCGGCTGCACTACGCGCCGGTCATGTCGGTGCAAACGGGCCGGCTTCTCGGAGTGGAGGCGCTGCTTCGCTGGGAGCGGGACGGCGTCTTGATTCCCGCCGGACAGTTCATAGCGGGGGCGGAGGCGACGGGGCTGCTTCCCGGTATCGGACGCTGGGTGCTGCGTGAGGCCTGCCGTCAGCACCGGAGCTGGAGGAATGCCGGTCATCCGGCCGTGACGATGTCCGTGAATATCTCGGCCCGCGAGCTGGCTGAGGAAGACTTCGTTGAAGGCGTAGGCCATGCGCTGAAGGAGACGGAGATGCAGGCGGAGTGGCTGCAGCTTGAGATTACGGAAGAGATCGGCCGGGGGAGGGCCACGCGGCTGTGCGATAGACTGAAGGAGCTCAAAGCCCTCGGCGTCCGGCTGTCGCTGGATGACTTCGGCGCGGGCGCCGCTTCGCTGAGGTTCCTGCAGCTGGCTCCGGTGGACGAACTGAAGCTGGACGGCAGGCTGATCGCCGCGCTGGGGGAATGCCCCGCCCGTCAGGCCATGCTGGAAGCGTTGATCTCTTTGGCTCACGGCCGCGGCATGCAGGTGATCGCCGAAGGGGTGGAGCGTTCCGGGCAGCTCGAGAAGCTGCGGGAGCTTGCCTGTGACGGGGCACAGGGGTACTGGTTCGGTCAGCCGATGGCGGCGGGAGAATTTGAGCGGCTGCTGAGCTACGAGCGGTTTCACCGCAAAGATTCGAGCCAAATCTCCTGA

Protein sequences of DBSCAN-SWA_2

>NC_016935|3407286:3417726|3408318_3409431_+|WP_014370016.1|DBSCAN-SWA
MIINDEMYMRIALQLAAAAAGQTGINPVVGCVLVKDGRVVGMGAHLKRGDAHAEIHALNMAGAEAAGSTAYVTLEPCSHHGRTGPCSDRLIREGVKRVVVAAVDPNPVVAGSGIARLRAQGIEVTEGVLAAESEALNEAFNKYIVTRRPFVTVKTASTLDGKVAAAGGDSKWITGEAARGYVHTLRHRHQAILTGVGTVMADDPQLTTRLPVPGLSPVRIIADSMLRIPLESKLLHDGEAPVIVLTTAEAPEDRRRALEALGVQVIDCGPGPAVDLEAALARLGELEIGSVLVEAGGKLAGAFLERRLADKLVLFFAPKIIGGGAEAPGTFDFPGFRAMRQAIRLERMTVETFGEDVCFTGYPSYEAADS
>NC_016935|3407286:3417726|3409469_3410138_+|WP_013916447.1|DBSCAN-SWA
MFTGIIEEIGTLRRIARQGEAMVLTIGASRVLEDVKLGDSISVNGVCLTVVSYDKESFTVDVMPETFRRTNLERLSSGSPLNLERAMAANGRFGGHIVQGHVDSTGTIVGRTAEANAVVFRVSPKDPGLLKYVLPHGSITIDGISLTVVEADNAEFTVSIIPHTLAETVLQHKKPGDEVNLEADVLGKYIERLLGFQGGQGGSMSRARGRLTADFLSDNGFL
>NC_016935|3407286:3417726|3411477_3411948_+|WP_013916449.1|DBSCAN-SWA
MAKVYEGHLVSQGLRYGIVVGRFNEFITNKLLGGALDALKRHGVQEDEIEIAWVPGAFEIPLITQKMAESGRYDAVITLGAVIRGSTPHFDYVCSEAAKGVAAIALKTGVPTIFGVLTTDSIEQAVERAGTKAGNKGWEAAASAIEMANLSKQFAK
>NC_016935|3407286:3417726|3410202_3411441_+|WP_013916448.1|DBSCAN-SWA
MSEANQEGKSPELRFHTIEEALADLNEGRVIIVVDDEDRENEGDFVALAEKSTPEVINFMIKEGRGLVCVPITEERAQELDLPPMVARNTDYHGTAFTVSVDAVETTTGISAAERSRTVQALIDPATKPHAFRRPGHMFPLVARKGGVLRRAGHTEAAVDLARLCGSYPAGVICEVIKEDGEMARVPELMEIAKKHDLKIITIQDLIAYRNRMEKLVQREVEVRMPTDFGVFTAVAYTNDVDGKEHVALVKGGIDSSRPTLVRVHSECLTGDVFHSHRCDCGPQLAAALKQIDEAGEGVLLYMRQEGRGIGLINKLKAYKLQETGLDTVDANLQLGFAADLRDYGIGAQILRDLGVGQIRLMTNNPRKIRGLEGYGLQVVERVPLQMQENEDNTGYLHTKRSKLGHLLEFNI
>NC_016935|3407286:3417726|3415260_3417726_+|WP_014370018.1|DBSCAN-SWA
MSGTYNVYLVLLSYLIAFMSAYSAFDLARRLSAAAARVRRLCLGLAGVILGIGIWAMHFVAILAYETSLSIHYDSLLMLLSVGFAVTASWAGLAGASRPAPGLRRLLASGCIVFAGVVGMHFIGMAAMGMGGDRYHWLLLMLGAAIGLAGSFGALFVSFRSQPAGGRNSYLRRLLGAAMMGGAIAGLHYLSMEAMTFGSVGHLHQRFRHAGHQDEMLGIILANCIIFLLSIIVIRGYFLDRRYREGEAFRLAVLESALDGILLVDHQGGIMECNPVMGGMFGYPREELATLHLTDLLEVPAGGSGDGGLSTEAEGREGPSGFALPVEAIRGLLDSRVETTGWRADGTAFPVEISLTRTEGFGRPVFTVFVRDITDRRKAEEHIRQMALRDPLTGLYNRSYLQEKLSSALSRAEGSRGTIGVMFLDLDGFKSINDTFGHDSGDMLLQEVGERLLHCVREEDLVSRQGGDEFIVMLSGVTPGTASSIAVRMIEALARPFYYAGREMTVTPSIGIALYPSAGTSAHVLVKHADAAMYQAKLNGKNHFQFYTAEMEASLSQQTKLEARLKLALQQDEFRLHYAPVMSVQTGRLLGVEALLRWERDGVLIPAGQFIAGAEATGLLPGIGRWVLREACRQHRSWRNAGHPAVTMSVNISARELAEEDFVEGVGHALKETEMQAEWLQLEITEEIGRGRATRLCDRLKELKALGVRLSLDDFGAGAASLRFLQLAPVDELKLDGRLIAALGECPARQAMLEALISLAHGRGMQVIAEGVERSGQLEKLRELACDGAQGYWFGQPMAAGEFERLLSYERFHRKDSSQIS
>NC_016935|3407286:3417726|3412744_3413362_+|WP_013916451.1|DBSCAN-SWA
MDSGQMKSVIEGLLFVAGDEGLSAKQLAEVLEHDAAFVKELVKDLQKDLKRTQRGIQIVELAGTFQLTTVPDHAPYFERLAHSPSRSSLSQAALETLAIVAYKQPITRVEIEEIRGVKAEKALQTLVSKDLIQEVDRADAPGRPILYGTTKAFLDYFALGSIDDLPETTLFEDDENLEEETRLLFEKLEGQQITFDELALGQESR
>NC_016935|3407286:3417726|3413484_3414168_+|WP_013916452.1|DBSCAN-SWA
MIWAWAAAGLAAIAIAALVLSQVTIQIGFSQKGKDEDITVNAKALFGLVKLKFEIPFIRFKNLQEGFEVKAKAKQVNSTAGQLLGQAMENIGPEMLRKAYENIRKLLENTLNFNEWLRHMLGRVRCTQMDWKTTVGIGDAAETAFLAGAFWGIKTSILGLLFRYIPLEGQPRLAVVPAFNQTLIAVEVMCTFRIRMAYILLSGVQLLWRVLKVKGGLKAWRNVLLPS
>NC_016935|3407286:3417726|3407286_3407718_+|WP_013916445.1|DBSCAN-SWA
MAKQAIIKMADGNEIVLDLFENDAPNTVANFEKLANSGFYNGIPFHRVIPGFVAQGGCPHGTGTGGPGYTINCEINPNKHERGTLAMAHAGRNTGGSQFYICYAPQPHLDGQHTVFGKVVKGMEHVDAFKGREKMETVQVVEA
>NC_016935|3407286:3417726|3411990_3412776_+|WP_013916450.1|DBSCAN-SWA
MKVTVKLETFEGPLDLLLHLIDQAEVDIYDIPIKDITDQYMEYLGAMQELELEVTSEFLVMAATLLSIKSKMLLPKPPVLDLEFDDYMQDEDYDPRAELVAKLIEYRKYKAIAEHLRDKESERSLIYTREPEDLTPYTPVKPENPVEGLHVADLVRAFRKALRRMESRSSVARIRKDEISVKDRMFQVVDLLARERGPVFFSRLLEQEASKDSIVVTFLALLELMKVKKITCYQHKLFDDIVIQAREDGAANGFWADEISY
>NC_016935|3407286:3417726|3414316_3414826_+|WP_014370017.1|DBSCAN-SWA
MTEHPIQGLMKTAMENIKEMVDVNTIVGDPVETPDGSVIMPISKVGFGFAAGGSEFVTTEEANPPGLTRHESHNAQVALPFGGGSGGGVSITPIAFLVVGKQGVKIVPLDNQTHLLERLIDSAPQVVDRIQSMMKSGGGGKSQGSEQSSSANAGATTVTNNIENQNFIV

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013916445.1|3407286_3407718_+	peptidylprolyl isomerase	A0A1B1IVS0	uncultured_Mediterranean_phage	4.2e-22	43.7
WP_014370016.1|3408318_3409431_+	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	3.7e-54	40.3
WP_013916447.1|3409469_3410138_+	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	7.0e-40	44.4
WP_013916448.1|3410202_3411441_+	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	9.3e-115	53.0
WP_013916449.1|3411477_3411948_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	5.8e-41	57.4
WP_013916450.1|3411990_3412776_+	segregation/condensation protein A	A0A1B1IVW1	uncultured_Mediterranean_phage	6.3e-08	35.6
WP_013916451.1|3412744_3413362_+	SMC-Scp complex subunit ScpB	A0A1B1IVT7	uncultured_Mediterranean_phage	1.4e-15	35.6
WP_013916452.1|3413484_3414168_+	DUF2953 domain-containing protein	NA	NA	NA	NA
WP_014370017.1|3414316_3414826_+	GerW family sporulation protein	NA	NA	NA	NA
WP_014370018.1|3415260_3417726_+	EAL domain-containing protein	G3MA91	Bacillus_virus	9.8e-23	35.6

Sequences of DBSCAN-SWA_3

Nucleotide sequences of DBSCAN-SWA_3

>NC_016935|6455366:6492424|DBSCAN-SWA
CCTATCCCGCCGCGTAATTGAACCGTAGGTTGTGATATCCAAGACGCCATGCAAGAACCCTGTACATGAACTTCTTCCCGGCTGGCCCGTGAATCGTAAAGCTGTCCGCGCCCCGGACAGGTACGGTAAACCCGTTACCGTCAATCCCCGTAACATGAACCTGGTAATCATCCCCGTAAATCTCGACGGTCTCCAGGAAGATAGGGTCCATCTGGATCACAACGGATCCGTCATCCCCGATCTGCCCCTCACCAAAGTCCTCGAATCGGTTCTCTGGACTCTCCATGGCATACAGCAGCTGCTCGCCATGGCTGGCCGTTTGGACAAACGCTGATTTTGTACCGCCTACGCTAAAAGCTTTCTCTACGCGGAATTGGGTAGTGTTCCACCAAGCCGTCACCTGATTGTTCGCGAAAATCTCCATCTGTCCGTCCGAGTTCCAGTTAAACCCGGTGTCATGGTCGCCAATTGCTACGGATATCGCAGGCGCACTGTTCATGGGGTTTTGGGCCGCTCCGTTATGGAGGAACGTCTTTCCAAATACGTTAACCTGGCCACGGCCGCGTACGGAGAACATAGGATTCCAACCGTTAAACAAGCTCACCGCCTCGAAGATACTTGTATCGTCATTGGCATATCGATTCGCCACGATTGCACCAACTGAAGAAGTCGAATCCTCGTAGTTGACGATATATGCCCCGAGTTTTACTCCTGCTGGAACCCCAATGAAAGTATCTGCTTGAATTTGCCTCCCTGGTTGCCGGCGGACATCAAGCGAAATGTTGTAAAAATCATTCGCTATAGTTACGGTTGGATGAAATACACCTCCATTTGTTGCCCCATGATCCATGGTGCCTAACTGTACACCGCGGTTACCAGCAATACGGGTACCATCAATGTTTTTCGTTGAGGTCTCATCGAAGTAACGAATAAAGTGATTCGTATCGGCACCATTTGTACTCCGGAGGTAAAGCGGTCCTTCATTCAGGTTGAGGGAGTATCCGGTGCCTAGATTGAGATTCCGGCCGCTGGTCCAGATATCTCCGGTATTACCGCTTAGCTTCCAATCAACCGTCCGGCCATCGCTCGGCCTTACCGCCCGGAAAAGAAAACCCTCGCCACCCATTCCATCATTGGCGGTATTAAAAATCTGCTTAATCCGGTATTTGTCAGTACCCATCGTTTCATTTTCCATGTTAAGGACTACATCGTGGCCCGAAGCTCCAGTCGCCTTAACGGTGAGAAAAGCATTATCGGCATCTCTTGTAACGGTAAGACCGCTGAACTGAACAGCGTCAGCCTTCTTCAGTGATTGATCAAAGTCGCTCTTATGAACAGCATTCTTCTGCAGCTCATCAAGTGCGGCATATGTTCTGTGCCATTGCCAGTTAAGCCAATTCGCTGGCAAGGGGTCGTCAATTTTGTGACCTATGGTTTTGTCGTCCTCTGGCGGTTCCACCCCAGAAGCGTACCACTCTGCTAATGGTGAATTGAATGCCATAGCGCCTCTCCTTTCTTAAATCGGCAATTCTGGAGTATCATCGCCGGCATACACATTGCCGAGGGTTCCGCCCGTTGTTTTCGCATCGTCGCCAAGTCCAAGCCCTGGTCTCTTTGCCGCCCCTACATCGGACAGCCGCAACGTACCAGAGAACTCGATCGATTCCACTTGGACCCCCGGGGAAACAACGCTCTTCACCAGCTGCAGAAACTGTGTGGTGCTGATCCCCATGGTATCCAATCGATTGTACGGCAGGCCGGCCACCCGGATCGCCGCCGGCTTTGGATCCACCTCATCCTCCGACAGCTCCTCCAGCTTGATCGTGGATGGATCAGAATCCAACGCGAGAGCGAGCACCTCGATGATCGAATCGAGCGTCCCGGTGGAAAGGTTCCGTGCGATCTTTGACCGGATCAGGGCCCTATAGATCGGGTCGCTTACGACGCCCCGCGGCTGCCCGACGTTGGAGCCGATCAGGTCGAGCGTCGTGCCCTCTGCCTGGTCCAAATCGCGCCAGGCGTGGATCTGCCACAGTACAGCCTCGATTTCATCCATTGGCTCCGCGGCCAGCCTTAAAAACTTGCTGATGTTGCTCTCTGGATTTTTCTTGAACACGTCAGTAAGTCGTTTCCTCATTTGCTCCCAGAAGCTCATGCCACCGTCACCCCGATATCTGCAGCATTGATCTGTGCCACCTGCTGCTCCTGGATCCCGATGTCATTCGTGGAGTAACTGCCGGCGGTCGTTCCGATGCCTCCATGCACGTTTTCCACGCCTGTGACGGTGTATGCGGCCCGGATGATCTTCGCCCACAGGACGTCCTCTCCCATGGTGCCCCCGGCGTACACCGTGCCGTCCGCAGTTTCTCCGCCGATGTACTGCACGATGGCATCTTTCACCTGATCGGCCACGTTAGAGGCTGCCGAGGAGTTTGTCTCCACCTGCAGGTTGGCGAAGATTGGAACCGTCGTCGGCCGGCTGAAGCGAATGGTCCGCAACGTGCCGGATATGTCCGCAACCTGTTGGGTAATGCTTCCCCAGGTCCGTATTCCGCCCGCTTTGTTGTCAAAGATTGCCCGGGCGATAGCAGCCTGCTCTCCGCCCAAGACATAGGTCTCAAAGGAATTGGGAGGTCGTCCTTCACTGTCAGGCACTTCTTCTTCGTTCTCGACTACCTTTACAGCTCGGACGCCGGGCAGGGCAGCGACGGAAGCCTGCAGGGAGTTCAGCGTCGCGGATCCGCGAGCTGCCCGGGAGGTCCGGAAGCGGGCACGGAATGCTGCGTCGCTTTCGCGGTCGGCCCCGTTCTCGATGGCCTCAAGGTTGGTTATGGCTGTAAGATTCGCGTCCGGATTGACCAGGACGCTGATCTCCCCGACGTCTGCGTTCCCGCTGCTCCCTGGGTTTACGGCCTGCACGGTTGTAATGCCCTTGCCGTTGCCGCCGAGCGTGACCGCATTCGTGATCACATACTGCGTGCCCGAGGGCTTTTGCGCGAGCAGTCCCGGGTTTACCATATAGCCGGCTGTCCCTGTCAGCTCAACCGGCCCGCTGGCGTAGGTGTCCACGATTCTCCTGACGCCCGCCTGGACGCCGAGGCGGTCGAGGGAGACACCTTCCGCCGTATCAACGAATGCAGATAAATATACTTTCTCGGCAACCATCCAGAGCACGGAGAGAAACCAAGCAAAAACCCGCAAGACTATGCCCACGGGTGACATTCTTGATGTATTGATATCTTCGCCGAACAACTCGCGGGCTTTTGCTTCGCCCTCTGCAAGCAGGTCGGCATACGTCTTACGTTTGAAGCCGCTGCTATCCAGCACCAGGTATCACCTCGCTTGACTCCAACGTCCGGCCATTCCAGGCCGTCGCCTTAAATTTGATGGATAGCACCCGCTTCGCCCGGTCGAAATTGACGAATTCAATCTGGTCCACCGTGCGGATCCGCGGCTCCCGCAGAATGGCTGCCGTCAGCTCCGCCTTGATTACGGCGTAATTGGGGCTCTTAACAAGAATCTTCCCGTAATAGTCGACGCCCATATTTGAGTCGAGGAACCACTCGCCCTTGTAGGTTGAGAACTCGATGCGGATACACTGCAGCAGCTCCTCGTCACCTTCGACCATCAGCAGCTCGCCGTCCTGGATGACTAGGTCGCCATCCTCGCCCAGTTTGAAGCTCTTCATCCTCCAATCACTCCTATCACGATCGCGTCGGAAAGGTGGTGAGTGCGGTTGATCTTAGGGTCTGCCGGCTGTCCGGCCAGCACGTGATCGATCGCCCGCTCCGCGACAACCGTGAGGACGATGTCACCAGCCTGGTAGTGCGGCGAATACTCCCGCACCTCGCCGCCCTCTACCCGGTACCGCTGCCTCAAGCAGGGAGCATTCGTGATCGGAGGGAGAGTGAAGGCCGTCCCGTCGATCCGCACCTGCTGGAAGAGCGGCTGCAGGTCACACGTCAGGCTCCCCGAATCGAAGGAGAGCACCCGACAAAGCTGGGCCGTGTGCAGGTTAAGAACCGCCCGGTCAATCATGCTGCGCAGCATGTTCTCGAAATCCCCCATCACATCAGCTCCATTTCCGTTGTGAATTCTGAATCGTTGCAGATATGCCGGCCCCGGCAAATGCGGTACACGAAATTGTAGTTCACGCTGAGCACCTGCAGGATCTTCGCGGTACCGAACCGGTGATTCAGCAGGCTCTGAACCGTGAACTGCTCCTCCTGCTCCTCGTCCTTCTTGCCATAGGTGACCCGGGCGGTCGTGGACCGCTTACGTTTCGTCTTCGGCTGCTTAGCGACGTAATCCAGGTTGGTCTTCGCGATATCAACCATGGTCAGCCGCGGCGAGCCAATCAGCCCTGTGTCCTCGCTCAAGGTGAAGTCCGTCTCCTCCCCGAAGAAGCGGGAGCAGACATACACCTGGCCGCGCGCCATGAAGGCGAGAGCAGCGCAGTCTGTAGCCACCTGCTTGAGAGAGTCAACGATCCGGCCGTAAACCGAATAGCCCCGCGGATACGTGACATCGTCCGGGAGCTCTATTTTGCCGATCGGCAGACCGAGTTGCCTGATCAAATCGTTTATTATGGTGCTCCCGGTTGTGCCCGGGCCGTACGTTTTCTCGAGCTGGGCCTCCACATAAACGTGGCTGTCGATACCCTTGATCATGATCCGGCTGTCAGGTTTCTCATGGAACGGCATCATCTCGGATACTTCGCCGACAAAGATGCTGCCCCGGTCGCCGCGGTACCCGGCATTGATGATCAGCTTCTGGCCGGCACTGATCTGGTTGTAGGTGTCGGAGGAGACATTGTAGATCGTCACGGTCGCCTCGTTCGGGATGACGTCGTCGTCGAAGGGGACGTCGAATTCGATGTCCAGCCCGCTCTGGCCGTCCATGTAAAAGCGCAGGTCCCCGACCAGCACCTCCACCTCGCGACCGAATGCGTTGATCTGCGTCACGGCTCCACCTCCAGGAAGACTGTCTCCTGCAGTGTGCCCCAGGTGACCGTCTCGACGATCCCGCTCTGGTCCAGGGGAGTGATCGTGAAGCGGGGAAAGCGCTCATCGCCCATGGACTGAAAGAGGGAAGAGCCATAAACCAGGGGCTCGCCTACAACGAGCACTTCTCCGCCGGTGGAAAGGTCCACCGTGAAGAAATCGAACATGTCGTTATAGCGGATCTCCCACTGGTACCGGACGTTTGCGATCACCACTTCGAATCGATAGGGGACCGCGGCCTTGTTGATGTTCAGCCGGTACATTACACCACTCTCACTTTCTGCCCGACCTGCAGCTTACGCGGATCTACTCCTGGGTTCAGCGCCTGAATGGCTGCCGTGGTCGTTTTGAACGTGCCGGCCAGGCGCCAGAAGCTATCCCCGGACTTGATGGTCGCATACACCTCGCCAGTTTTCTGCTCGAGCTGCTGCATGCCTTGGTTGCCGGTCGCCGCGGCTGCCGTGCCGGTAGGGTCTGTGGACTCCGGTACCGACTGGGTCACCGTTACGATCCGAGCTTCCTCGAGCTCCAGAGTGAAGCGGAAGCCATTGGCGATCTTATAGTCATGCTCGGTCGGCATGCTTTTGATCAGCATGGTATAGGCGGCGTTCCGGCCGTCATACACGACCAGATCACCACGCTCGGCCATGGCCCAGATCTGAATCCGTTTATCGCCGGCATCCGGACCGACGACTTCGCCAGTGAGGGAAAGGCGCCTGGCCGTCCTTTTGACATGGTCAGCAATATCCTTGCCCTTCTCGACAGGCCTTGTCGGGATCTGGACTTCAAACGGTACCCGCTCCTCGACCACGTGTATCTCGATTCCGTTCAGCGCCGCCATGTCATCTCACCACCGGTTGAGGATCTCGTCTCATAATGCTACGGGCATAGGCATCGAGAGCTGCCATGGTTCCGTTGTACGCATCCTCCCGGCTGGTATTACCGTGAAAGTGCTGAACAATTGGAGGCAGCTGCATTCCGCCGCTAGGTGTTTGCCCGGAGTTGTATGCTCGGTTCTCTTCTGCCGTGAGCACCCGCTCTCCTTTATGGAGTTCCGCCCGATAACCATCGAATGGGATGTACGGATGTCCGTCTTCATGAGAACCGTCAAATTGGCGACCAATCTCCATCTGTTCGGCATTGTATGCCTCAGAGTTTGCGGTCGAACCGTACCCGTTATAATGGTTATTGACCATTGTTACAGCGGCATCGTAGGTGCTCTTTACATCCCCAATCGCTTGGAAAAGATCACTGACTCCCGTACTTACCTCTTGTACCAAAGGTCCAAGTATAGGTACAGATTTTGCAGCATCAGCGACACCCTGTGCCACGCCCTTAACAATACCTGCGCCTAGAGATACGCCAATTTGCGTTAAGGGACCCGAGGCTTCTGCGAGAGAGGTTGCAAGTGTACTTGTTATTTCACGAGATATGTTATACGCTTTTTCCCTTCCGGTTTTGTTATACCAAGCCATGAAGGTATCTTCAATGTCGTTAAATACGTAATCGACCTTTGCCTCAAAACTCAAATCTCTAAACGCTTGATTATCAATGTACTTTTCCCTAAGATAATCAGCCATCCGATTAGCAGAGGAAACGATACGGTCCTCATTGCGTTCAACCACGTTACCAAGTCCATCAAACAGCTGTCGGGCAAATGGAAGAAAAGGCTTGAGGGTACGGATCTGCAAGGTCTCGAATGCACCCTTTAATTCCTCGATAGAACCTCGTGTGTTATCCATTTTCTTTTTTGCGACATCATAAGCGGTTACGTTTAACATGTCTTTCTGGAACTGCCGCACGCCTTCGCTTCCATTCTTAAACAACATGGAAGCCGCTCGGATACCATCTGATCCAAAAATCTCATCAAACATTTTAAGTCGTTGTTGATCATTCATCGGTGCAAAAACCTTCTGAATTGCGTCCGCAATACCCTCTAGGTTTTTTATTTTTCCGTTGTCGAAGAACAGGTTTTTAGCGTCATTTCCAAGTCCAATCTCGTCAAAAAGGCCTGACTCTTTATCGCCCGATGCCTGCAGATTAAGAAGGAGTGACTTGATGCTTGTGCCGGGGTCAGATCCACCTATTGCCCCGTCATTCGACATAAGGCCTATCGCCGTAATTACATCCTTTAGGTTTCCTCCGGTCATATCCTGAACACCACCCACGGAAGCCAGCGCATAACCCAGTTCATGAACACTGGTAGCCGAGGTATTGGCCGCACCTGCAAGGATATTGGCTACGTCCGCTGCTTCAAGCCCATCCTTTTTGAACGTGTTCAGCGTACGCCCGAGCGTGGCCGCTGCTTCTTCGAGACTTAGCCCGCCTGCAGTAGCAAGATCGAGTCCAGCTTGAAGACCTTCACTCACAACTCGCTCGATCTTCATACCTGCTTTCAAAAGTTCTTCCGATCCCCGAGCTGCCTCGAGAGCAGAGTACTTCGTGGCAGCCCCTACAGCCAGCGCTTTATCTTCCACTGCTTTCATACCCTCATTCGAGAGACCAGTGAGTGCTTGTATGGAAGAGAGCTGGGCCTCAAAGTCCATTGCCCTACTCATTGAATTGCTAGCTAATAGTGTAGCTCCAGCTGCCGCGGCGACTCCGGACCCTACTGCAGTATTTCTCAACATACCCGTAGCAGAACCTGTAACCCTTTGAATGCTCTGAAAAGCACCTGTTGCACTCTTCTTCAGGGCATCCATAGCCGAGCTCGATTGGCAGATGCTACTTGTAAGCTTGTCCATTGATCGACTGGATTGGGTAGCCTTCGATCCTGCGCTGGCAAGCTCTCGTTCAAACTTCCTGGCAGTTCCGTCTCCCATCCTGCGTTTGAGCTCATCCATTGCCTTGTTGGCTTTACGTAGTGGGCCATCCTCAATCTCCCAGGCGACGGAAAGGGCGAGCTTCCGCAGGTACTTGTCCATTAAAAGTCACCTCTCTTTGCCTTCAGCCTTTGCCAGATTGTGACGGCCGCATTGGCCTCGTTCAGCTCATCCATATCCATTGCAAATGCTTCACTGTAGGAGATTCCTCCTGTCTCAAGAACCGGTCTCCAGAACAGCCAGTTCCTCTCAGCTTTCTTCTCCCACTCTTGCTGGCTCATCTTTTGGCCGGACGATAAGAAATCGCAGCGCCTCCGCGAAGACCTCCTTCATAATGTCTTCCCGCTCCGGCTCCGCATCCCACCACTCCCATGTGGTTTTAGGAAAAACGATGACGTGCTCCATCAACTGGGTGAACAGCGGCTCGTCTGCCAGGTGACCGTGCTGATCACGGCTAGTATCCTTGATCCTTGTGGCTAGTCGCAATCCTGGGTGCTGAAACGTGAACTCGATCCCGCCAGCGGTATATTTCATCTGTCTACGTTGCATACGTATTTCCCCCTTTAGAAAAGAGGCCCCATTCGGGCCCCCGATTATTGAGTATAATCAAACACTTGGAACTCGAAGGACCGATTACTATCTGTTGCATCATCGGAATAGTTCACGGCAGCCGGACGCTTGATTCGAGCTTGTGTTCCACCAATCTTCTCTTTTGGACGCCCGTTGTAGAACACCCAGATAGGAACCATCGTCTTGCTCACGGCCAGGCGGTTGAGGTATTCGACATACGGGGAGGATTGCTGGAGAGTGACGGTGATCGTCCCCAGCGGGTTGTTTACCTCCGACACGCTTACGTCTCCCTGGGCGCCGACGCTGGTCGTGAATTCGTCCTCGTCCTTGCTAGCGGTGACGAAAGAGTCCTCAGCAACGCCGGTCAGGAAGATGTTGTTGACTGTTATTGCAACGTCCTTCGCGTTGAACGTGCTTACGTTCTTCAATACTCACACCCCCTATGCGCTAACCGTGCCGGTGATCTCTGCTGCATGGATCGCCCCGGCCAGCTCGTATTTGAATTTTGCGTTACGCAGGATCCGCTCCGCCCGGTCGATCGTGGTCGTCTCTGCTCGCGATGGGAAGTCGGTGGAGTAGAGCGGGATGCCGTCCGCATCCTCGGCGATGATCTCCTGGCGATAGGCGATGCCCAGCACCGTCCGAACGACGCTCTCGATCTGCGAGATGCCGCCGTTCGTATAGCTGATCTTCTCGCCACTATTGAAGAGCGCCTGCACCTGCTCCTCGATGTTGGCCGCCACCCAGTGGTTGCCCATAATGACGTCGATGTATTCGCCAGTCAGCACCTGTCCTTCGCTCGTCACCGGCGTGCCAGCTTTGGTCACGTAGGCGTTCCCGCCGTTGTCGTGGACATCCTGCAGTCCCGCTGCGTCCAGGTCGTCCGGCAGGATTCCGACCAGCCTGTGGCCCTTCCAGGTCACGGTACCGACCGTGCGGCTGCCTACCCGGCCGACCCAAGCTGCATCTGGATACTTTGCAACCTCATCCGGATCGCTGTGGTACATGACGAAGGTCAGCTCGTTGCCCGTAGCTTTGAGGTCGACCAGATCGGTCAGGTTACTTGTCCGGGTGACGAAGAGCTTGCGGCCCTGGCCCTCCACGTAGTTGGAGAGTTCGATGACTTCCGCCTTCACCGTGGAGGTGCTGATGAGGAAGTACCAGTCCTTGCTGTAATTGGCCGTCAGCACATCGAGTGCGTCGCTCGTACTACCGCTATCGTAGGCAGCCACCGCGAACACCTGTGGCCGGTTATCTCCCTGGCCCATAACAGCTGCCGCCGCTTTGTATACCTCGCTGCCTACCGCGAAGCCATCCGCCACCAGTGCGGTAAGGTCGCTGTAATTCTTGTATGCCTGGCCGCCAGTCTTCGGACCGATGATCAGCGGCTTGCCGAAGCCGATCAGGCCCGCCGGCCGCGAGAGGCTGATCGTGACTTTCACGTCTTTTAAAGGCAATGCCTTCAACTCCCTTCTGTAATTTCTGCTTGCTCGATGAATTCTCCGGGCCCAACATGCCAATCTAAGGCCCTGAACCTGACGTCGGCACCATAGCGGCGTTCGTAGTGCTCAACGAGCGCTACGCTCCGATTCTGAACGTCTGAGATGCGCACCACAACCAAACCTTGCTCCGCCAGAACTTCGCGGTCCTCCCGGTTGAAATGATCCAGGATCCGCATGCACAGCTCTTCTGCCTCGTCGATATCCTCGGAGTAGACTGTAAAGGAGGCGACGAGTTCCACCGTGCGCACCCGCTCCAGGTTTTCGCCGACAACCTGCTCGATGTCCTTGCCGAAAATATCAATGTACGGAGATGTCAGGCTGTACACAACATAAGGGTAGGGCGGCACATCTCCCTCGTCATCGGCGCGGATCACGGGCTGCTGCAGCTTGGCATACAGCCCGGCCACGATCATCGAACGAATCGCTCTTAGATCAAGCATCCGGCCCCCGTCCTTTCGTGCTTACTCGTTTGGCGATATAGATCCGGTGATCTGAATATTCATCGTATGGCTTGGCCTCGAGCACTCGGTACTCCAGACCCTTATGCATAATCCGGTCATCGATGGCCAGCTCAGCCGGCAGTCGCACGTAAATCTTCCGGTCGTCCCGGGTATACGTGCCGCCAGTCTCCAGCTGCAGCTCTTCAAATGACATCGGAACGATGATCCCTTCCATTTCTACCGGTGCGCCATACCCCGGCACCCACTTTCCGCCGTTGGCATAGTCGTAATACCCCCCGCCTTTAGGGAAGCGGTGGAATTTCTTCCCCCACTCACCAAACACTTCGGCAAAATCAAAATGCGGCATCAGCTGCTCACCACCTTCCATGTCACGGACTGCCGCAGACGGCCGGTATCGATGAGCGGGCTGCTACTCTTCTTCCTGGAGCGGGTGATAGGGGCGTTCTCAGGCTCCATGTCACGCATGGTCTCCTGAATATCCCCGACGATGCGGGCGCCGAGTCGCTCATAGAACGTCTCCACACTCATCTTCCCGTCCAACACATCGGCCAGGAATCGCCCGGCCAGCTTGTTCCATTCGGCCTGCTTGGCATCGGTGGTGGAACGAATAAAGGAGCGTTCGGGTATCTTCACAGACGGGACCAGGATAAACATGATCTCCGACCGGGCGCCTACCTTCCCGCTCCTTTGCCGGTCCCGCACCAGGAGACCCTTCCGGCCGCCGTCGATCGGTACGAACCGAAGGTCATTAAACTCCCGTGCCGTCTTATCCCCGGCCAGCGCCGTTGGGATCGTCAGGAACCGCTTCTTCGCATTAATGGTCAATCCGAACTCGTGGACGCTGGCCAGCATAGCCATAAACGAATCGTCGGAGCCGAACACGCCGATCTCGATCGCCTTGCTGTTCAGTGCCCGGATGGTCCGGATTACGTCCGGTATCCGGTTGGTGTCCTTGATCGTGATCCTGGCCATCAGAGCACCATCAGCCCGAGCCCCGGGCCAGTCTCCGGCGGCTTCAGATCCAGGAGATCCAGCAACCTAAGGTACTCCTGGCCGTATGGCGTGGAGGCTAGGCCTTCGCCCTTGGCGCCGGTACCGGAGTCGTACGTGACTTTCATGTCCCCGACCTGCTGGGAAGTCGAGCGGCGGACGTTCATGCTTGCCAGGTGCGCGGCCAGGTACCGCGGCAGCCGCTCCTCATAGCCGGCGATCTTCTCAGCCGGGAAGGATGCGATCTCAATTATGGCGTCATCAATGAAGAGCTGCAGCTGCGGATCCGTAAGCGCACCGAGGTGCGAAGCGATCGCCCGCACCCTATCTGGAGTCGTTGGCATAAGCCGGCAGCCTCCTATTCGTTCGCCTTTTTGGCTTCTTTCTCGCGCGCTTCCTGGAAGGACTTCTCGATGTCCTCCAGCTGCTTGTCGATCGCTGCCAGTACAGTCTTTCTGTTCTGGCCAGCAGCCTCTTCATCACGGAGATCCCCAAGGAGCTCGCGGGAGAAGGTGTCCTTAACCAAGGATGCAACCTCTGCAGCGGTCATGTCAGCCAATCCCGCCGTCTTCTGTTCCCTCGTCACCTGGTTACCTTCAATACGTTCCACTGTACGGATCTGAGGAACGATCTCACCCTCATCGACCAGTCTCTGATTGAGCGGATGGGCAATAAAATCCGCCCAGTCCTCATCAGAAATGTTGTTGACGCCTGGCACAAGACGGACGCCGTTTTGATTGCGGACATAATTTCCCTTGTTGTGTACCAGCATTAGATTCCATCTCCTCTCGCAATAGCCATAGGATAGCGGATTACGACGCCGCCGCAGCGCTCTTCAACAACGAACTTCCATTTCGGGAACTCCCACTCCGGATCATGGCGCATCATGTCCATAGGAAGCAGCAGCTCCATGACCTCAGACGATGCGTCGAAGATCAGCATGGAGTCCGTGCCACCCGTGCCTGCGCCTCTCAGCTCAGGTGCACGGTCAATCGATCTGAACCAGTTGTAGCTCTGGATCACCTGCAGGACAGTACGGGAATCGTACTCGTTGTATCGGCTGTTCAGAATCTCGAACTGATTCGGAGGCAGGGCGAGAGCCAGTGGAGCGGTCATGTGTCCAGGGAGGACCGAGACCAAGGAGCGAACGATACGAACGTCTTCGACGATTTCTTCGCCCGTCTTATCCTTCCACTTCGTGCTTGTTCCGTCCGCTCTTGGCGGGACGTTCGTCGTCTGGATGCCCGTAGCGTTGATCAGGCCGGGGATATTGAAGTCCGGGTCACCGATCCAGGCCAGACGGTTCTCTTTCTCGGCCACAGCACGGCGGGCGACACCTGCTTTCGTCGAATCAATAGTCTGGCCGGTCATTTGAGCTGCGCGCTGTTCCTGAACCGTGTAGGCGAAGCCTGCCACGATGGAATAGATGCGCTGGAACTCCCGGCGCGTGTCAACGTCTACGAACGGCACGTCGTCTGCGTTGTTGGCCAGAATCTTGGCCACACCGGAGCGGGTCATGACATCATATGCATAGGTCTCTGCCCCTGCAGGGATATCAGTCTTGAGGTTCAGAATACGGCGAGCTGTGAGCTCCTCATATTTCAGTTCATATAATCTGCGGTCGATTGCCTCGAGGTCCATACCTCGGAAAGCTACTTGGTTCATCATTCAGGGGACACCTCCATTATTGGTTTGGCAGATTGAGTTCAAGTTGTGCAAGGCCGTTAGCGAGTGCGGAGGTTTTGAACTCACCCAGTACCCCCGACTTGCCGGTAGTCGCCGTAGTGGATGGGCGGAAGTCGCCGGTTGCGTTGTCCGCAACGGCCAGGTCGCCCTTAACCACGTCTTCCAGCACCTGCACCCAGATCACGCCTTTGCGCAGGATCGACGCAGCGTCGTTAGTCTCGTACTGGCCGACAATTTCGTTATTGATGTTCGTGACGCGGTTCTCAGCGTAGTGGTTAGCGATGGCCACGCCGGCCACTTTGCGGGCCCCGGTATACACCTCGCCGCGGTTCTGATTCGTTGCCGTGTAAGAGACCGCTTTGCCCCAAGGAACTACGCCGGCAGCTCCCACCGTATCAGCCCGGTGCTCAGGATAAAGAGCGACGCGGCCTTTACCTGTCGGTTCCTGCATGTACTGATCGTATCCGCTAGTGATAGGCATGGTTTATTTCCCCTCTTTCCAGTGGTCTTTTACGTTCAAACGAGCGGACTTTGCCTTCGCGATCTCGTCCTGTGTGTCAGAAGTGTAGCTTCCAGTGATTACACTGTTGGCGCCGGTGGAGGTGAATCCATCAGTGCGGGCCCGCTCTACCGATGCATCGTAGAAAGCATCGATGTACTCATCGCTCTTGCCATCTGCTTTGAAATCAGCGCCCTTCACCTTCTGGATCACAGCCACCTTCACATCGCGATCTGTCTTACCGGAGAAGTCAAAGGAATCGCCGAGGAACTTTCGGGCTCCGTCGATAAGAGCCACACGAGCAGCAATAGCTGCGTCAAGTTTGTCCGCCGTGAGAACCTGCTTTTTTGCATTCTCCAGATCTCCCTTCAAAGTATCGCGCTCTGCTTCCAGGGCGTCATACCGGCCCTGCAGCTTATCGTACTCGCCGACTTTCGTATTGGCTGCGTCCAGGCGGGCCTCCAGGACATCAAGCTTACTCTTCACTTCACTCGGCACCTCAAACTCCTTGCCGTCAATCGTGTACATTGCCATAGTTTGGCCTCCTTCGTTAATGTCTTCTTCATCAATCTCAAAGGCGGAATCTCCGCGGATTGCCACATGCGGGCCGGCGCGGCCCCGGGCCACGATAGCAATATGGTTGATCGCGATGTTCGTCTGTTTTGCGTCGTAACGCTGGCCCATGTATTCACCAGGCTCCTGGATCAGGTCGGTCTCAAAGCCGATGCTGATCTCCTTCTGCTTCCCGCTCCGGACCCGCTCGATCAAGGACCGGTCCGTCACCGTCATCGTGACCACAATCTTGTCATCTTCGACTCGGCTATCCGTATGGCTCATGCCCCGGGAGTATTTCTGAATGTTATCCAGGGTGACCGGCTCAGGAGGATGCTCGTCGGTGACCGGCTTTGCTCGGGCGCTTTGCACCACAGCATCAGAAAGAATGTCCTCCGGCAGCTTAGCTTCAAACTGGATCCCTCCGTCGCCGCGACGGTAAGGGAATACCCCCGGCCGAGTAATGCCGGCCCGCACGGTCAAGAAGCCGGCAGCGTCTTCCTGGTAGTCAAGCACCATGGCCCGATCAAATCTTTGCAGTTTCATCTTCGTTATCACCCCCTTTCCGGGTAACAAAAAAAGGACTTCTAAAAAGAAGTCCCTTTTTGTTGTCTAATATTCTATTCAAAAATCTCAAACATACTTTTTCTTACGTTTTCTGGATGTAGACCGTACTGTATTGGCTTAAGGATATTATAGTTTTTTTCTTTAGTGTACATATTCGCCGAAATTGTTTCAGGATCAATCTCTACAATTAGAGAATTATAATCTAAATCATAGTATTCTTTATACCCTGAATGATTGACATCTGGAAAGTTATTCTTAAGTTTGTCATTAAACTCTGGTTTAAAATAATTTATTAGCGCAGCTTCTGTTATATTAATTATCTGCTTGTTTATGTGTAGCGGCGGGTCCTTTATTATCTGCATCATATGTTGAATATCTTCTGACTCACTTACATCATAAACTTTACTTTTTCCATCAAATAAAGAAAATAACTTTGGTGTAAACTCCCACAAAGATATTGCTAAGTCTCTTACAGTACCGTTGAATAAAAGATCAGATTGAATTTCTTGTAATGTACTGTGTGATTTTAATCTGTCTAACGCCTGCCTCTCACCTTCTTTACCAAATGATTGGCCTATGTAAAGAATTTCACAGTCAATTTTTCCTGGAGTGTTCCTCAAGTAAAACGGCAATACCCTGAAAATAGTTCCTTTGCCTTGACTATCCGTGATCTGTATTGATCTAAGTGGCTTATCAAATTCGATATTCAGTGTTCTATGGTCAATACTGCTTTTAAATTTAAAATTAAAATCTTCAACGTAGTCAGCCGTTTCTGTTTGTACTCTTACTGCAACTGAAATAGCTTCCTCAGCAACTCTCAAAGTATCTTTTACAAATGTGAGTCTCGGAATGAGATTGATCATATAAATGTGGTACTTGAAATTGGAAAAATCAAAATTACCCATGTCGTTTGGATAGAAAATGGAAGCATGCGAGCTATAGGTGTGAAGTGCAAATTCAGCCAAGTATTTTCTTTTTTCTTGCTTCTTATTGATACAACAGCGTTTATATTTCAGTCCACTGCCACAAAAACATAGATCATTCCTACCGATTTTATTGGCCATTCTACACACTCCTGATGTGCTGTTTTCCCTTAATTATAGCAGATAATTACCTTTTAAATTGGGTCTACTGTACATCAATATAAGGATTTAGAACTGGCTTCCGTAATAAAAAGGCCGCTTTTTTAGCGACCAGTCCTGAATATCAGTTCTTCTTTTTCTCAGGTACACCAATTAAGTATTGGTCTACTGTCCACTTATGTACTGGATTCCCCCCCCTCCCAGGTACAATGCATCTGTGAGTTACTAGAGCACTTTTTGAAATTCCACGAAGTTTTAATATCTCCCCTATTTTTTGTCTTGAGGCCTTAAGTCCACCCATTTTAGCCTCCGGAATTCTCGCAACCTCACTTCCAATTCCATTGATCCACTCACGGACCACGTAGTCGCCACCTTCTCTAGCCCCTTCTATGGAAAAATCATGTTTGATCATTATCATCCTCTCCCTTCAGTCATTATCCTTATTATAAGGCAAGATTTTCCGAATTCTGAAAAGGTTTCACAAAAAAAGTCGCTCATTATCCTGAGCGACCATCATTCCTTCTTATCCTCTTTTGGCGGTTCGTCTTTCGGCTTCTTTTCCGGCCGTTTGATGATCAAACCTTCCGCACTCTTCCACATGAATTTGTCCGGGTTCGGTACTTCATGTTCACTCATTCTTCATCACCACCGCTAGGATTTGTATAACGCCCGATGCGTCCTTTGAAGCCTCGACGATCTTTATTGTGCTGCCCCTATCGAGAAGAAATTCATACTCCGAATCCTGAAACAGGCTGATCGGATTAACGAGTGCGCCCCTTGATCCGGCCGGCACCTTTATCTCCATCTTCACCGTGCCCGAGAAACTGGTTGAGCTGAGCAGACTGGTACTCATGTAACCCGGATCCGTGACCTCCAGGCCTACCATTTCATCTACAGGTCCGAATATGTTGCTGTAAAGTCCACGATAAACAGTGATGTGCTCCTCAAGCTCGAACTTCCGCAGCCCCGAGCTGATGTTGTTCACGAGATCATCAGGCGGATTCCCCGCTCGCAGGCTCTTGTTGATCGTTGCATACGCGCTGCCGGTATATTTCGTTATGGCGCTGGTCTCCAGTGCATTAAGGCTTTTTAGGTAGGCAGGCGCGACTTTCTTTTCCCATTCCTTGACCTCATCGGCGGTCTGGAAGACACGGGCGTTCTTTATTATATCACTTTCCGTCTCCTGCGGGGAATCCGCCGGCGCGACTACATCCTCGTCGTCATCATCGAAAACAGGGATCGCAACGCACCTGCAGCGATAATCTGTACCAGGAAGCTTATGCTTGCCGTACTCGTACACCTTCCCATCGTATCCGCGGTGTTCCGGCCGGACCCGCTCGTCGTGGGATGTAGACCATTTGAACTTACGGATCCCAGCAGATTGATGCCGCTTAGCAGTCATCTGCCCGAGAATGCTACCCGTTTGGTCCACAGCGATGAACTTGGCCTTGCTGTAGCTGACATCGGCCGCCTTCTTGATCTTGCCGGTGAGCTGCCGTAGGCTCTGCCCGTTCTTCACGCCCTGTAGGACGGATGCCTCGACCTTGGCGTAGTAGTCGTCCATGATCTTGGTGATATACCCGACGTTCTCGGTCACCGATGCCCGCATAAATGAATCGAGCCAGGGCTCCTGAACGGTGGGATCAATACCAACCACACGCTGCACCTGGTCTCCGATGTTTCGCTTATTGTACTGATTGATGCGGCTGACGAAGTGCTCAGCCAGCTTTGTGATGCGCTGCGGTGTGAATATGAAGGTCTTCGCTCGGTCTTTGGCTAGCCGCAGTGTAGCCAAGATCGTTTCGAGCGGGCCGTCATAACGGGCGCTATCCTGCTGGTATCGGCGCGCTTCCTCCTTCAGGATGCGATTGAAGATGTCCAGCGTGCCGCTGTGCATTTCCCGGATCAGGCCAGACACGGCCGCCGCATGACTCCGGGCGATGATGTCAGGGAAGCGGGTGGGGAGGGGCTTAAGCCGTCGTCTTGCCACCGCTGTCACCCCTTCATCCTCTTATCGAACCCTTCCATGAGCGTGCGCCATTCTTCTTCAGATAAGCCGTCCTGCTTCTGTTCGGGCTCCTCGGGTTCCTTCGCTTCTTCAACGCCCGGAGCGTCACCGTCCAAGCTGCCGAAACGAATCTTCCGGACTTCGTCGTCGGTTAAAACACCGTTTTGTAGATATATCTCATCCGCTTCGGCAATCATTTTGCGGATCTTTGCGTCGGTTTCCTGATCCACGTTCCAGAGCGGGTTGAATACCACTTCCCACTCCAAGGCGTCGGGGTCGATCTTCCCGCCTAGCTCACCATCAGAGATCAGCAGGTACCGGATCAGCCGCTCGATGTGAGGACGCAGCTCGGTCTCCTGGGCGGCCGCGATCCGGCTGTAATAGTTCAGCACGTCGTACTGTGCTCCAGCGATCGTGCCCGCTTCCTGCCCTTTGATGACACTCTTTGGCATCTTGGCAGCACCGCTGAGGGACTCCCATACGAAGTCGAGCAAGTAGTTGATGCCGGTGACGTTAGTAGTGACCTTGTCCAGATCTTCCTTCGTCCCAATGATCGCCATAGCCTCAGTGCGGAACATGAAGTCAGCGAGTGACTGGAATTCGTACTTTTCTTCACGTGTCATCTGATTCACGCCATCAGTTTTGTAACGTTTGAACGTGAAATCATACAGGATCTGCCCGACGGACCAGAGAGCCGTATCAAAAACAGTGAGAACATCCCACATTGGCTCCAGGATTGATTGGCCTTGGTACCTGTCCTCCATGCGCCTGGTCTGGTCATGGAATAGCCGGCTGCGATGAACCACTCCTGCATCCTGTACCCCGACAAGGATCTGAGAACCTATGGCACTGCGGCGGTTGATCTGAAATGACTCCACTTCTCCGTAATTAGGGGAGAACATGTCCTCATTCAAGTAGAAGTTGCCAACCTTGTAGGAGCTGAATGCATGCAAGTAGTCGATCCGAAGCAGCTGATTCTCTTCCAGCGGGTCAGATAGTTTAAAATCATTCTTTTGAGCCGCACCGATAGATACAAAGCCGTCCCCATGCAGGCGCTCATACCGGCGCATGTCACAGAATCGCTCCTTACTGCTTAGGTCCCGCAATTTACGCATGAGCATGTCCCGCAGATTCGTGTCCTTCATCCGGATGGTGATCCAGCTCCGGGTCAGGTCTTCTGCCGGTATGTCGACTAGATTCTGGACGAATTGACTGGAAGCATAGTAGTTCAGTAAGTCCTGCTCAGTCAGTTCCTTGCGGCTCGTCGCTATCCGTTGCCGGGTTAAGGAATCTTTTCCGGTTCCCTTACCATGCCCGACAAGAAAGTCATTGCGGTAGGCGTTATAGCTGCTTCTCATGTTGTCTAGTCGTGTATGTGGCATTCTCTCATCTTCACCTCCTTGCCCATCTGCGCAAGTTATCAAGGGAACTAGTGCCCTGTTTCATATCTTCTTCAAATGCGTAGCGGGTCGCGTCGATCGTGTGATTGTTGACGTCCTCGAGCTTTGGCTTTGGATTACCATCAGTATCCGTTTGATAATCGATGTCCTCGAACTCTTTCGCCAGGTTGGGAGTACGTTTCGGGTCGATTATGATCTCATCAAGGTCATCGAGCCATTTCTCTCCGAACTCAACGGATCCAGGACCTTTCTCGGCGCCGATAATTCTGATAGAGTGCTCATCCCGCATCTGATCAACTGATTTGGGTTCAGCACTATCAGCAATCGTCATATATCTCTCGTAACCCTTGAACTTCATCCGTTCAGCTGCTTCCCGGTTGGACATCTTCACGCCGCATATTTCATCCAATGCGAATATCCGCCGACGTGTTTTATCGTAGTGCCAACGAACAAAAGCGAAGGGATCGGTACCGTACCCCCAGTCGATACCTTGCCGGATGTTCTCGAACCGACCGAGCTCCTCCTCCGTGATCGTACGGAAGACCAGGTTATCGAAGGGAACGACGCCACTGCCGATCGCTTTACCTAGGTACTCCCAATCGTACTTGAGAGGCCGCTTACGCTTGACCTCTTCCGCCTCCTCGACGAATGCCTTGGAGATGTACGGGTTATCCAGATAAGTGGAATGATGAACGTATGTGTTCTTTGGAAGATCGACCTTTGACTCGTATACCTTGTTCACCCAGCTTTGCTTGCGCTTGGGCGGATTGTAAGAGTAGTAGAAGGCATAAAAAAGACCGTCGGGCAGCTCCGCGCGCAGCACGGACTTCTCGATGGTCGAAATATCATCTTCAGCTGTAAACTCGGCCAGTTCCTCGATCCAGAGGAAGGCGATTGGGAACTTGCTGACCTTAATCGATTTGATCTTCCCCGGATCGTCCGCCCCACGAAAGATGATCTTGTTCCCGCGGGGCAAGTAGATGAGCTGAAGCGGGCTCTTCATGATCTTCCAATATGCACTCACGCCGAGTATCTCGATCGCTTCCTTTAGCTGCTCGAATACTGACTCCTCGAGCGTCCTGCCGACCCGGCGAATACAAAGACCCGTTACTGGGTAACGCATCATATCAACAATGAACTTAAGTGCTATGTGAGTCGACTTGGCTGACCCCCGGCCGCCCTTCAGTACATGGCGAAGGTATTTACGGGAGTTGGCTGCTTTCCAGAAGGACTGAAAGTGCGGCGTGACGATCTCTGAAAGCTTAACCTGGATCATCCATCCCGCCCCCGATGTCGTCTACGATCTGCACACCAACATTTGCGTTAATATTCAGGTTGTCCTTAAACATCCCCAGGTGTCTTCCCAGCTTCTCCAGCGCTGCGCTCTTATCATGCAGCTTCAGCTTTTTGGTGCGTCTTACGTTGCCGCCGGCGATCTCCAGCTCCTGCTCCGTGATCTCAGCGATGCAAGCAGCATCATCGGGGCTTAGCTTGTCGCTGCTCTTAAAAGATACGCCGTCCTCATCCCATTCAGCGAAGTCGCTCATCTTGGCGAAGGCCAGCTTGGCCAGCTCCTGGAGAACCCGATCCGCGGTAACACCAGTGCGCTTAGAACGCTCCGCCTGGGCTTTGGCTATTGCTTCCTGAACTGAAGTTTTCTGAAGGAGCTGGTGTCCTTGTTCCATAGCGGTCTTAACGCTGTAACCGGCCCTTATGGCTGCCTGAGTCGCGTTTAGATCAATAAGATACTCCTCTACAAATCGTTGTTGCTTGGCTGTCAGTGCCATCTACACGATCACCACCTCCAAGAACAGAAAAAGCACCACTAGGGCGCTTCGCTGTCCTTCTCATTGTCTTTTGGGTTCCACCATTTGTTCTTCCGCGGAATCGGACGGCCTTTATCGTCTGTCCAATCTTCATAAATGGACCGGGATTCATCGTTGAGGCAGACGTAGAGTCTTGAGTACTCCCTGTTCCCCATGTAGTCATTGTCCTGGACATTCATCAGTTCATTGCAGTATAAACATCTCACGGTATCCCCTCCCTTAACCATTGTAGGGAGTACAAACCTGAGTTGTCTATAACATTCAGAACCGTACCTAATTTCGCTTTTCTACACAAAATCGAACATGTGTATGGCCAGCGACGATCATGTCTTAGAATCGATTCTCGGGACTCTCTTTCCCGTCATCAATCCGATAAACTTGCCATTCAGATATAGCGCGACAACTTGCTCCCCCTCAAACTCGCAAATATGCTCCCATCGGATATGGGACACCACACTCACTCACCTCCGTGAAAAGAAAAAAAGCACCTCGCGGGTGCTTTCTACAACTTTTATTGTGAATTTATGTGTTCTAAGAAAACCATTAATGTTTTTACACTATTACCCTCTTCATCAACTTCGATGTCAAGGATAGCATTATAAAATCTCCCTTGCCAAAAACTGTCTTTATCGGGCCATCTTAAATTAACCTCATTATGCTCCTTTAAAAAAGCAAGAAGTTCTGCTACGTTATCACATTCTTCAGCGAAGATCTCTCCTCCGCCTTCGTTGTCATGGTATGTCACTTTCATATTCATTTCCACCTCCCCCCAACCATTGATTCAACAACGTGAAGGAAATCCCTGTCAAACAATGCTAAAGATTACCTAAAGAAAAAACACCGCATGGGTGCTCTGTCAGATGAGTGTCATTTACTCAGTTTCTTGTATTTTTCTCTTATTAATTCCATCTGATCTTCTAATACCATAACTGCAGCTAACAATTGTTGGTATTCTCTCTTAAATTTTTCATATAAATAATTTTCATCTAGGCCATTTTCGTATTTTAAGAAATACTTCCAATGGCTAATAGTGAGCAAATACACATCTGTCATATCATAAAACTTTTCACTTACTAAAGCGGCTTTTTCTTTAAGGGCATCCTTTCCTTTGAGTATATCCTCAACGGCAAGTGAGACACCTACTATCTTATTATGAATTTCATATTTATCCCCAAAGAGATACTCTTTTATTACCCTGGTCATAGCATCAAGTTCTCCATGAACATCGTCTCCGTTAGTTCTCACTTTAAGATAGTCTCTTAAAAAATCTGCACTACGCTGGTTCTTAATAGTGATCCTAACACCAAAAAGGGTAATAAAACCTCCAACAATAGCACCTATAAACGCGAGTGGATCCCAGTTTGATGGAATTGCAGGTCCTAATTCTTTCAGGAGAATAATCAATATTAAGGTGGATATACAAACCATGATGAAGATAAAAATACGTGCCATCCAAAGAATGAATCTATCGCCCGACATCAGCCCACCGCTCCCTTGTCTTCATACCTCCTTGATTCGACAAAATATTTGTAATTCCTTCCTCTATTTATCCCTTCCTCAGTGGATCGGCCGGCACTGAGCAAGGGACAAAGTCCCTTGTTTAGGGAGACAAGTCAATCCCTAAAGTGGGGCATTTCACCCCACCTCATATCACACCCCTGACGACTGGCGTCTAAGGACCGAAATGCGTCCCACAGCATGACCGAGTGCCTGAGGTGATAAGGGTCCATTAGGCATTACCCGCAGCGGTGTTTCAGCTGCTGTAATGCTATGGTACCAACGAATATACGTTCGAAAATGCCACAAAAGTGACATTCTGCTCTACCACCATCCAAGCCTATTGGCTATGTCTTCGACGATCTCATCCCGCCAGCGGTATGCTGTTCTCTTAGTACAGTAGAGCTTCTGAGCAATGCCTTCCCAGGTGAGCAGCTGCGGCCGGGTCCAATACCTGAGCTTGATCAGTTCCTGCTTATCGGCCGGCAGTCGCAACACTACCCCATCTATAGCATCAATGATCCGCTGCATCTCGTCGTGCTTCCGGTACTGCATGATGAGAGTACCGGGGCAGCCAGTCTGATCCTGTAGCAGTTCGTTCTTTATTCTGATGATCTCTTTTCTGGTTTCGTGGTATTCCCGCAGCTCGTCCTCAACATGCTGATAGGTACCCCGTTTTATCTTTATCTGACTCATCCCCCGCACCCCTCACCGTATGTTATACTGTGGTTGTGCGATTTGCTCATTCATAGCCCCGCCGATCCTCCCAAGATCGACGGGGCTTTTTATCAAACGATGAATCCCAGCTGTGACAGCTCCCGCTTATCGACCTCAGCGCAGCCGCTGGAGGATTCCTTGCTTACACCGGTGATGCTTCGAAAAGCAGCCTGCAGGATCATGATAGATTGGCTATCGTATTTGACAATGTAATTGCCAGTTTCGTGTTTTTGGTATGAGATTATTTTCATTGATTTCCCTCCACCAATAATTTACCATAGATTTACATGTAATTTATTTACTTTTTTAACTCTATTTTGTATTATTAGAAAGTACCAAAAATTAGGAGGTTGAGAGAATGAAGAAAAAAGCACTAATGTTGATGACAGTTGTTGCTGCCGTACTTAGCTTTTCGACATCCGCTTCTGCCGCTTACTCTAAAGTGTTCGGGCCTCAAGATTTACAAGGGGTAGTTTATTTGGAAGGTGGGGTTAGTAACCCTACTTCCACAAAAGCTTATATTAATTTTAAGCTCTGGCAAGTAACCCCAAGTGGTGACGTGTTGATTCGTAGAGACCTTCTTGGCCTTGATGCTTATTCTAGTGCTCACTTTTCTGAGAGCAGTGTTGTAAGCCTTCCATGGGGGACTTACAAATACGAGATTGTTGCAAAAGATGGCGTCAGAGCTTCAGGCGTAATGGGCGCCAGATAAGTAATCAATCTTTTATATTACAGGCTAAGAGCACTCGTTTTCTTAGCCTGTTTTTCTATTTATTTTGATAAATGCTTAAGTTCATGTAAGAGCGAGGCAATCTGTTCTGCCTGCCGTTCTATCGTCTCGGCCATCTCCCGCAACTCGGAGACCTTAACCAGCTGCAGCACGATGCCTTGAGAGATAATCACCTGGAGTCCTTCCTTCAGCTCTTGCACCTGATCATTGTTCATGGTCTTCCTCCAATCTTCATGAGCAAGAAATTGAGCTGCAGCTTCGTAAGCCCAAGCCGCTCGGCTAACACCCTGCGACTTGTGCTTCTCCTGTGAGCGGCCAAGTAGAACTTTTGATCTTCGTTCAAATCAACGTTCAAAGATAATTCGATTAATGAGTCCGATCCTTCCTCATGATCAGGAGCGGGTTTCGGCCGCCCCCTATTTCCTCTGATCTCATACTCTCCATCCAGAGCCTTGAATCTGTAACTTCCCTTCACACCCGACCTGCTAACAAGTCCAAGCTTCATAAGCGTCCGCAAATGGGTATAGACGGTAAATGAGGCATAGCCTGTAGCACTTAATACTCCTTTGGTGGTACCGTGAATCCGTAAGGCCTCCAGGACATCGACTTCATTCTTTGTGATTTGTGGGTTCATGGTTATGCTCCCTTCCAGATCCGCTTAACCGTTGAGGTATTCCGGTGCATGATGACCAGCTCCTCTGGGGTTTCCCGCTCCACCAGCCAGTTCTCCGGGTTGAGCTTCACTTTAGCGATCACGATCTTCTGCCGGCGTGTCGGCCGCGTACCTTGTTTCATATGGCATCCTCCTTAGTCGATGCAGATCATACCGCTGGTAATGCGTTCTACATCATCGAGGGTGGCAGGCGTAATGATAAACGCCCGCCCCTTGATGACGATGATCTCCTGCTCGTGTTCCTTGAGCTCCAGGATCCGTTCTTCGTAGGGAAATGAACTCATTCTCTTACGCCGCCCCGTTCCTTTTCAGTTTCTGTGCCACACGTTTCTTGTACTTGCCCCAGGAAGCCTGCAGTTGCGTGGAGCTCAGTCCATGCTTGGAGGCGATCTCCATCCAGCTGCAATTCGTTTCGATCTTCTCGACGAAGAGGGCCGGATCGAATTCGACGTCATCGAAGCGGGGCTTCTCCTGCAGGATGTGGTTCTCGACTTCCTCCTTGCTCGGATCCGGACCGGCGCCCTGATCCTCATCTGCAGCGTAGGCCCCGTCGGCCGTTCCGCCTTCGTCAGCAGATTGTTCATCGGCAGCCGGCGCGTACCCGTCCTCGAAACTCAATTCAAGATCAGGATTCGGCGCTGCTTGATCTGCCTGCAGATTTTCTTGTGAGTCATCCGGCTGGTCAAGGATCGTTGCCTGGTTTCCATCCTCTGCCGACTGCACGACTCCCGATCTGTCTACTACAGCCTTCAATCCTTGGTGTGGGGCAGAGGAGGAGGCAAGGTAATCGGAGATGCTCATCTGCATGTCACCAAGAACAAAATCGACCTCTTCCGGGTCGCTTTCGAAGAACTTCGCGTTTTTGAAGAAGTCCCGCTTGCTGATCTCCAGTACGATTTTCACGTTCTTGGACCCTACAGTGATACCGCCGATATTTGCCTTTCCTTTTGCTGCTACCATGACCGATCATCCTCTCAGTTTTTGTATGACTTCCTGCTGGACCTTAATTAGCTTCACCGGCTCGTGCATCGCCCGGACGATCTGGGCGAGCACGTAGGCGTCGGTTACGTTGTTACTCTTGTGCTGGAATCCCCAGCGTTTGTATGTCTCCACCGCGACTTCTTCCTTCCCGGCATTCCCCCCGGAACCCGTGAATTTCTTCAGCTGCGATGGAGCTATTTCGGTGTATCCGATCTTTCTAGCGAAGAGGTTCAGCCGGATTCCCCATCCAATGCCGCCCAGCTCAAACCCTCGCTGGCTGGCAAAACCGAAACCCTCTACCGCAACCCGGTCGCCTGGCTGAATTAGCAGGCCTACCTGGCAAATCAGGTCATGCATCCTTCCCGGATTCTCGCCCTTCCCCTCGAGCTCCCGAGCCTCCCAGATCTCGCCGTCCTCATCCAGAACCACGAATCCAGTCTTGGTGCTGGGGTCAAGCCCGACGTATCTAGGCATCCTGCAGCACCTTCTCGAGCTCCATGCTCGCTTGGAAGAGCCCCGCACTTTTTCCGGTTTTGAACCCCTCCACATACTCACCGGATGCTCCGTGCATGTTAGGAACTTGTAGCTGCCTTGCCTTCGTTTCCAGATCATCGATTATCCGTCTAATGATTGCCCGCATCGTCGGGTCCATCAATAACCCACCGCCTTCACGCAGCGTAAGCCACGACGTGCTTTCTTCGGCGCAAAGATAAATCGATCAGCAAGGACATACACTGCGCCGAGCTGCTCCTTGCCCTCGTAGATCACGAAACGATGCGTCACCTGAAAGAGAGGATCACTTACCTTTCGCATGGTGCCGCCTCCTCTGTGGGATACTCCATGATCGCTATGAGAAATTCATCGATACCTTCAACCAGCTCACCCGGATCCAGCCGGCCTGAGAAGTGTTGCTGTGCTTGTCCCATGGAGGGAATGATGCCGGTTGCCATATATGTTTGCTTCAGCCACTCGTATACGTGCCATCGGTTCATGGCATTCACCTCACCCTGTGATTTTCTGAGTGTCCTTGTCGTAATTGAGCTTCACGGTGCCCGTTGGTCCGTTCCGCTGCTTCGCCACATTGACCTCTAGGATCCCCTTGTCGGAAGTCTCGGGGTTGTAGTACTCATCCCTGTACAGCAGGATGATGTCGTCCGCTACAGCTGCGATCGCCGCACTCCCTGACAGGTCTGAGACCATTGGCCGCTTGTTCGCCCGGCTGTCCACGTCCTGCTTCACCTGGGATAGTCCAATCACCGCACAATCGCAGTCTTTGGCTGCCGCACGGAGCTTCTGGCATACACGGTGGAGTGCTGAGCCGCCATTGTCGTTCTGCTCGGCCGTCTCGTTGATCTCCTGAAGGTAATCAACGACCACCAGGTCGAGTCCCTCTTGACGCTTCATCCGCCGCATTTCCGAGGTGATGTATTCCGTCGTTACGCCGCGGGAGTCATCAATGGGGATCTTAGCGAACTCGTCCAGCTTGTCCGCGATCTGGCCGATCTGGAAGTCCGTCAGATTCCCGATCCGGATGGCCTGAAGCGGGATCCCGCACATCGACGAGGCCATCCGGTTATAAATTTGCTCGATCGTCATTTCGAGACTGAAGTCGGCCACTCTGTTCCCTCGTGAGGAGGCACGCACCTTTATCTCGTTAGCGAAGGCCGATTTCCCCATACTCGTCCGGGCCCCGACCACAATCAGGTTGCTACGTTGGAATCCAAGGGTCATCTGATCGAGCTTCTCCCATCCGGTCAGGATACCGAAGGCGATCTTGGGATTTTGTTTGCGGAGAAGGAGGTTCTCGAACCACGTCCGGATCCGGTCCCCCGATTTGTTCTCTTGGCTTACTTTCGGCCGAATCTCCAATGCCTTCTGCTCGAAAGTGTCCAGGATCTCGTCGAACCTGCCGGCAGCCGGATCATCTATGAGTGTCCTGGTCTGATCGATAAGCTGCGAAAGCTTGCGGCGGGCGTCCAACTCGGCCAGCAGCTTCATGTTCTGCCTGATCTCGCTGACCGACACCACCGATCCGATGACCTTGAGGAGGTAATCGACGCCACCGATCTTGGCGACGTCCTTTGCGAAGTAGGTGGAGATGTTCGTGTAATTCACCGGGTGCCCGTTCTTGTCCAGCCACGACATCATCCGGTATAAATTTCGGTTCCAGGGCTGCCGGAACATATCAATCGTTACGGTGTTAAGCACTTCACGGGCGAGGCTGGGATCTTCAAAAACCGTCCCAAGGATAACCATCTCAAGAGCTTCAGTTTGCAGCATTAGAGTTGATACACCTCTCGTAATTTCTGGGCTATTGGATCGTCATCAGCCAACTGGTAATCAGCCGGGCCACCAACAATCTGAAGGTTTTTATCTTTATGCGGTCCGCCGCGTGCTTTGTATCCGTTCAGCACCCCGTTGATATAGGCGAGGGTGCGAATCTTGTGGCGGACGGCTTCGCGCATTGCTTCCAGCAGCCATTCGCCGCCGTAGGTTTCAAACTGGTCGGTAAGGTCCTGGACTTCAAACTCCGAAACGTTCCCGTTCTCGGTGAAGTGTTTCTCATAGATCGTGTAAATTTTTGAGAATGAAAAGTCCTTGCTACGGCTGGCTGCTGGCGCTGTACCTTGATTCAACATAAGTATCTTAGTACTACTACTGTCTGTGTTAATGTCTTTAATAATGTCTATAGGAGGCTGGGAGCCCGCGTCCTGATTGGGCTCATCGGGGGTCGAGTGCGTTATTTTAACGCGATTTCCTTCTAAATTCGCGTTATTTTGACGCGATGCGTCGCGTTGTTTTAACGCGATTTCGTTTTCGCTACCTTCAAAATCGCGTTGTTTTAACGCATTTTTTCGCGTTGTTTTAACGCGATTTTTCGCGTTAATTTGACGCGATTCATCGAGATTGAGAGCGAGTAACTCATCAAATTTGAACTCATTCCAGCCACCTCCGAGAGGCACTTTCCACTCGTCGTAATTCTTATTAATCTCGAATGTTTTCTTCTCTCGGTCGCGGATGAGCACCCCTAATGCTTCCAGCCGATCCAATTCTCTATGAAAATTTCCTGTAGGAATTCCGCAAAGTTCGAAGTAAACCAATTTGGGTATATAGGCTGTTTTCTGACCTTTGCATCCATATGATAGTCGCCAAATAAAGAAGATGATGTCCTTTTGCCGCTTGGAGAAGTCGCGACGGATGACTTCATCCCATAACTCATTCGCGATCCGTACTGTACCATTCTCTGGCTGTGGATTCGCCATCCGGCGCCCTCCTCTGCGTTAGGTTTATCCGGCGTAGCGGTTCTTCATAGGGACCAACGTAGCATGCTCAGGAGCCCAGGAAGGCGGTCCATACTTGTCCAGGTACCCAAGACGATTAACGTATCCAGAAACACTCCCCTCGGCGTCCAGGGCCTTCAGAAGGTCCCAGGTGGCCAGCACGTCGTTGAGCGCCCTATGAGCGCCTGAGAGGGCGATATCGTAACGATCGCACATGTCGGTAAGTTTGTGAGGATAGACGTGCCTGTCACGGCTAATTGTGCAGGTGTCGATGAAGGAGTTACCGTACGTCTTGCCGGCAAGTCTCATTAACGAGTGGTGGAGGAACGCCAGGTCAAAGGCTGCGTTATGGGCGACCAACAAGCTCTCGCCGATCAAGTTTTTCAGGATCTTAAAGGCGAGCAGCTCGTTCATGCCAGTGGAAAGCATATAAGGGGTGATCCCCGTCAGGTCTATGATCTTGGGGTCGAGCCCGCCAGGGAAGTCCTGGCGGACGATGGTGTCGAACTGCGAAACGATCTCGCCATTGATGCAGCGGATCGCGGCCATTTCGATTACTCTGCAGTTCTTCGAATCCAGTCCGGATGTCTCGAAGTCAAAAACAGTAACATCGTTCAGAATGCTCATAGTGTCCTCCTGCGGTCATCCCGCAAATAGATCAGGGGGTACTTCGCCCGGACGACAATGAATCCAGGGTACGTGCGGGCGAAGTATGATTTGACCTCCTGTTTGAACCGTGCTGGATCGGACTCCATCAGAGCCCATAAGCTTTGATGGATCATCGACTTCATCAGTGGAGTTTCGTTGTGCATGTTCATTATTCAAACTCGACCTGGTCATCCGGCGGGCGGTCATTCAGGAGGCCTGTATCAGGGTCCCGCTGCTCATCACCTCCCCCTGCATCCTCAGCCGACGACTCGCTCCAGTCGGTTACGTCAATGACCTCAGACATGTCATCGGAGACTTCCCGTTTGGTTGTCTCGTCCATGGATACGGCCTTCTGAAACTCTACGGATATCGGCATATATTTCATCAGGGCCTTGAGCACCGTTTTTTTCGCCATCTCATCGAAGTGGTCCACCCAAGGTCCAAACTTTGCTTTCGAGAACTTGTCACGGTGAAGCTCAATGTCCCGTTTACTCATGACCATGAAAGAGTAGCCGCCATCCTTGAATTTCGCGTAAGCATAGTACTTAGTAACGGGTCCGCGGTCACCGTCCGCCGGCACATGCCGGAGCTTTTCATTGATGCCGTATTCGTATTCGAACAGGTCCTTCTCGTGAACTGCTTGGGACATGATGCTGGAAATATGTCCAGTCCTGCGGGCCAGCTCGATCAGTCCTTTGTAACCGATCTGAAACTGAGCCTCGTCGACGAAGTATTCCTTGTTCCCTTCCTTCTTCTTGTTGCGATAGGGTACCAGGTAGGCATGGCCTAAAATGGAGGGCTCCAGACCCAGCTGGGCGCATTGCATAACGGCGCCGAGAAGGGACTCTGGGGTGCATACTTTCAATTTGGGGTTGGTCCGGATGGAGGTTGTTGCGATGCGCAACAACCTCTCCGGCGTGAGGTGCTTCGGAATGGCCTGGGCGATAGCCGGCTTCATCTCATCAAAGAGCTGGGCTATCGTCTTTCCCTGGCCATTTCCTGCCGCGGCCTTGTTGGCCAATGCCTTGCTGAGGTCTTTCTGATCTGTTGCTTTAGCGGGTGCTGCCATGGCTATTCGTCACCTCCGACAATTTTGAAGCTTCGGACGCCCTTTTTATTGGACTTCCAGGAGAATACCGGCTCGCCTTGGAACCAGGCCATTTCGTGATCCGCCATGACGGCCTTCATCCGGTTCTTGGCCGTCTCGTGCGTCTCCTCGGCGTGCTTGAGGGCTTTCTTGCTGTCCAAGACCATCCGCATAAGATCGTAATTCTCTTCACCCAGCTCGATATTCGAACCGGGCCGTGACTCAGGAAACCGATCCTTGAGGAGCCCGGTATCCTGATGTCCGTAAGCGGGAGGCTGCTTGGCCAGCACGTGATTGTTCCAGAAGTTATACTCGATCTCGATCAGGTTCCCGATCAGTTCCTCATCCCGTTCGATTACCCGCCATTGGAAGTCCCAGCCACCGATCAGTACAGCGACGTACCAGCGAACCGCACCGGTGACGGCCATGTAGTGATTGCACTGCAGCATGTACTCCACCGGCACTTTCTCGCCCGTCCACTCATCACGGTTGTATTCGGAGGTGTTCTTAATCTCGAGGCCCTCGTTCTTACCGATGACCCAGCGATCAATGTTCGCCAGCATGAAGTCGTGCTCCCGGTGCTGGAAGATCGAGTGCTGCTGCATGACCCGGATCCCCGTCTCCTCGGTAAACCACTTTGCGATCAACGGCTCGAGCATCCGGCCGGCTTTCATCTTGTCGTTATCTTCGAGAGGCGGCAGCTCACCGATCTTATCGAGGTAGACGGCCATTGGCGATCTGTACTTGGATAGTTCGCAGATCGCTGCTACGTCACTGCCGCCGATGCCTTTCCGGCGAAACTCGAGCCAATCTTCCTTGGGCATGTCCTTAACGCGGGCCAGCTTGAGAGCTTGCATGGTTATCATTCCCCCTTGATGTGGAGTCCGCCAGCATGTTACACTGGCGGCAAGTTGATTTTGTAAGGGCCCGCTGGCAGGCGGGTTCTTTTTTTGTTTCTCTGAAAAAGGAATTGCTACTTTGAAGCTACAGTCTCTGTAGCCTTTTTCATTGTTTTAAGCATGTAGTACACAGACTGGTCTTTACGAACGGGCTGGTTTTTGTGAAAAATAATGTTGAGCTGCTCGGCGATTTTTGATGCTGACATCTTCTCTCCGTGAAGCTTCTCCACCGTCTCTTTCTCTTCCGTCGTGAAACGAATTTGCACTTTACTCTTTGCCATACCTAGATCACTCCCATTATTTTTTATGATGTGGCTTGGCCGCATCTCTGAAGATCCGGCGTACCGGACCCTCACCAGATATGGTCAAACTGCGGACGTGATGATTTTCTCATCCGTTCTATAGAAAGCATCATCAGCTATTGCCTTGGAGCAGCTGGTGCATATCCGTTTGAATGGTGCGTATTCCTTCATGGGCTTGCCCAAACCGCCGCAGATCGTGCACCCTGGCGAGTACTTCCGCAGGATAACTTCGCCTTCGCTGGTGAATACTTCAAGTGAATCGCCGAGACCAATTTGAAGGGTCCTTCGCAGCTCGATCGGGATCACGATTCTTCCAAGCTCGTCGACCTTTCTTACAATGCCGGTTGCCATTCTCATCTGAATGCAGCTCCTTCGCTCATTTTGATTTCACGTGAGATCACGTATCGCGCATTTGTGTCTTGGCAGCTGGGGCAGGCTGGCTCATCGAGCTGTCCCGCTTCGACTGCATATCCCAAGCAGCACTCCTGGCATTCGTAGAAGTCGTAAATGATCGATTCAGGCATCCGGCGCCGCCCCCTTCCCACGAACAACCGTTCTGTGGTAAACTGACAGCACGAGGACTCTTAACCGGGATCTCAATGAGGCTCGCCCCCCCAGGCGAGTCTTTTCTATTTCTGCCGCATGCTCCATTTCTCGATCGGACTCAGCGATCAGCACGTCGATTAGCTCCATGCCCTCGATCACCGCCGGGCTCTTCTTCCAGGCAAGCATTTGAGCACGCCATTGGTGCTCCGTGATTGGGCTTCTCATATCCTCCGAATCTCCTCTTCATCAATTTTCAAATCGTCAAGCACTTCCGCCGTGCAATCCTTGCAAGCTTTGCCGATCTTATTAATCCAATACACAGCGGGCTCTTCGCATCCAGCGATCTCGCACATTTTGCTAAAATCCAACATGCTGCATGTTCCCTCCGTCATAATAGAATTGGAATTGCTTTGGTGGGTTCTTGCACACCCACATCCAGTTTTCGTATGTAACGGCGTCCGGAACTTGTTTCCCGTTCTCGATCCGGCTTACCGTTGATTGAGTCAAAGCTAGGTAATCGGCCAGCTGTTCTTGCGAGTAATGGGCTTTTAAGCGGAGCCAGCGCAGTTTTTCGCTTACCTCCCGTGTGGAGATCATCGCGCTCACCTCCTTTCCCATTTATGCTGAATCCGCATGGTACTCTGTCAGCCGAGGGGTTATGATTGGTTTATCAGATCACATCCCCCTCACCTCCCCCCCACCGCCCGTCGCCCTAGGAGACGGGCTTTCCTCTACCCATCAGGGCACTTCCCGCTTCAACCAGTTGATAAAATCCACTTTAAGTACGCAGTATGGTTTTTCTCCCCCATTAGCCAGCGGAAAGTCCGGCCGATTCATCACTGAGTATGTGTGGCTGGTGGACCAACGTGTCATTTCAATGATGTCGTTCGCCGACAGCAGATCCGGATAATCTGCGAATGGCTCCCGCGGCTGCTCCTTTTTAAGCAGCATCTCCGCCAAATTCCCCAACAACTCCATAACCTTATGCTCGTAAATCGTTGGTTGATTTTGCGCCATCTGAAATCGCATCTCCTTTCATTCGCGCTCCACTTTCGATCCCATCAAGCATCTCCAGCAGTTCTTCTAGGTCCTTCACGACCTCTTCGATCGTGTATCCCATATCCATCTCTGTCTGCAGCCCAACAATCGTCCGAAGCACCATTGCCTTCGCTTCGACCACCGACCATGCAACCTGAACGTCCTTCATAAGTCACCACCTATACGGACGATAAATTCAACTTTACGTTTAAATTTTCGTCAAAAAAATTTGAGACCGGCTCATCTAAAGCTTGAGCAATGCTCTCCAATTCTTGGACGGTGATGGCACGCTTGCCATTCTCCTTCATGTTGTAGTTAGCAATAGTCATTCCCACCTTCTTAGCCACGAAAGTTTGAGATACGCCCTTCGATTTCCTTACTTCTCTGATTCTTTCAAAGATTTCCACTCCATCACCGCCCTTAAACGTAAAGTTGAATCTTTAAGTAGAGTATATTTCAACAAATCGTTTAAGTCAACACGTTATTAAACTTAATGTTGATTCATTTTAACGCAACGTTAAAACGTGGTAACATATACTCAAATTATGGATAGGGCGGGCATACATATGTCATTAGGATCAAGATTGAAATCAGAACGTGAAAAGCGCGGTTGGTCTCAATTGTTGGCAGCAGAAAAACTAGGCATTACAAATGCTGTCCTTTCAAACTATGAGAGGGATTACAGAGACCCAGATACTGAGACACTTAAAAAAATGGCAGATCTTTACGAGGTGACCACGGATTACCTATTAGGCAGGGTAGAAGCAGAAAAACCAAACACTTATGAAGATCCCCTTGAAGATCCCTATCGAAGCATTCACTTTAATGGGTGGGATAAACTTTCACCTGAGGATCAAGAGGAAATAAAGGCGTTTTTTAGAGCAAAAATTATGATCAGAGAAGCAGAGGAAAGAAACAAGCGGAATAAAAAAAATTGAGGTGTTAAATTGGACAACCGAGATTTAGGGAAAATAGAGCATTCCCCCATTAAAACAAATGTCCAAATTAAAGAATCGAAGCAGCCAATAAAAACGCCTGGTTGTATGAGTTTTTTGGTGTGGAGCTCAATTATCATAGTCGTTCTAATTCTTATTGCACTCAGAAATGAAGACGAAAAGAAAACCGTAACCCAATCAATTACTAATACCAAAGTAGAACAAGCACGAAAAAACCTAGATCCAACAACACAGAGGCTTATCTCATTTAATGTAACACCTCATGAATCAGTTGTTCGATATGGCCAGCAATTAAAATATTCATTAATACTGAAGAATGAAGGAGATCATACAATAAACGGAGCAAACATCTCTGTAGATGGTGATTGGTATAAATATTCGAATATATCACTTTCTGAAAATGCAAAATTAGAAAATGGGATTTTGAGTGACAAGATCATATATTCCGATAAAATTGAGCCTCAGCAACAAGTGACAATTGAATTTACAGGTACTGTAAATGATGGTACCGAAATTGATCCCGCAGGTTTTATTTGTCAGTTTATTCCAACAACTACCTTTGATAATAGAAAATTTGTTGGCGATGTAGATAAACAGACATTGCAGGTCTACATACTCCCAGAAAAACAAGGTGCAGAAAACGTTAATGTCAGCGTATCGGAGGCGAAAAGGGAACTAGCAAACTATACACCTGCAATGATTGATTTCAATCTTGAAACTAAAATTAACACACTATCCTCTGGAGAAAAAGCTGAGTTAGTTTTAAATATAGAGAACAAAGGCGATCGGCCAATTGAGGGCCTGTATATGTATGCCAGCAATGATTTTAGCTACCTCGAGAATCTTCAGGTTTCCAGTGGTCAGATTGAACCTGGTCTGCTAACCCAAACAATTAAAATAGAAAATGTAATTAATCCAAACACTTCAATGACATTAACCATTACTGGAACACTCAATAAAATAACTAAAGAGAAACTAAAGTTAACTGTCTCTCCAGGAAGATCAGTCAATGGCGAAGAGGTTATTGTCTTAGGCGATTCAGAAAAAAAGAAATAGAAATTTCTCTTACAAATTAGTTATTCGCCCTTATGGGCTTTTCTTTTATAGCAAAAGGCGAACGTATATTCGAAAAACGACTCGCTGCCGAGGTGGATCATGAATTTGACAAAGTATCAGACCACGCACTTGGAAGACTTCGTGGACGAGCTTTATCGAAGGCTCAACGTTTCTAGCCCAGAGCAATTGACTGTTGAGTATATTTCAACAGCTTTGGGCATTCGAGTTGATTACGCGCCTATTAGCTGTAGCGACGAATGTGGAGGTCGTTTCATTATTTATTTGAATTTTAATCTCCCTCCAAGTGATCACTTTAAAGAATTCCTTCATGAACTTGGCCACGCAATGAGACATGAGGGGAATCAAATACATATGCACCCTCTCATGCGGGAATGGCAAGAATGGGATGCAGAAAACTTTGTACTCTACGCGAGCATACCTTTCCTCCTGCTTCGTATAATGGAACTCCCGAGAGACCAACATTCAGCGATCGAACTTATCGCAACTACATTCAGAGTAGATCCAGAGATGGCACACACACGATACCATCAAATTTTACGTAGGATATATTGTTCAATGTGGAGGTAATTTTCGATGGCCGTCAAACTGAAGGGCACGATCCGCGAACGCGGCGACAAATTTGAGTATGTAATCGACGTAGGTCGGCATCCAGTGACGGGGAAGCGAATGCAGGAAACGGGGACGAGGGCTACTTATGCCGATGCCGAACAGGCCCTGATAGAGATCAATCGGAACATTCAGCTGGGGCAGAATATAAGAAGTGTTACTCTAGGGGAGTTTATAACGAGGTATTACGAAGAAGTTGTGAAGTATGATGTTCGCCCTCCCACCTTCCACCAGCAAATGCATATGGTATCTTTGATCATTCCGAAACTCGGCGACAAGCGGATCGATAAAATCAGTTACGACGATATTGAAAACTTATACAAAAAATTGTTGGACGAAGGTCGTGGCAAAGCCACAATAAAAAACGTATGCATGGTGCTCCGAAAAACTTTCAAGCACGCAATGATAAAAAGACTTATAATGTATGATGTTGCTAAAGAAGTGAAGCCCTTTGCTTATAGGCCCCCACGGATGAACGTGTGGCTGCCAGAGCAGGTCAATCACTTTTTGATGACGATGAAAGGGACGGAGCGGCATGCCTTTTATTCACTCGCATTTTCAACCGGCATGCGGATCGGTGAGATTACTGGTTTATACCACTCCGATATAACACCACAGACAAATGAGGTCCATGTTAGGCGCGCTCTCAAGAAGCTGAGGGGTGTTGGATTGGTGTTCGATGATCCAAAGACGGAGAACTCAATTCGAAGCATTGAAATCCATCCGAAGCTCACGCAGCTCCTTCTGGAGATAAAACCTAAACCAGGCACACCGGTACTCTTCACGAATCGAGTAAATAAGCCGATGGATCCGAAGGCAGTCCGGGAAGTGTTCCAAAAAGATATAGCAGCGAGTAAACTGCCTCCCATTAGGTTCCATGATATAAGGCATACCGTCGCCACAACCCTCTTAGCCAGCGGCATCCCTGTCCACTCTGTAGCTGAAATCTTAGGCGACAAGGTGGAGACAGTCCTTACCACTTACGCTCACGTGCTCCCTAAAATGAGAACCGAAGCTGCTCATAGTATTCACAGATCTTTCTTTGAAATATGA

Protein sequences of DBSCAN-SWA_3

>NC_016935|6455366:6492424|6463439_6463739_-|WP_014371571.1|DBSCAN-SWA
MQRRQMKYTAGGIEFTFQHPGLRLATRIKDTSRDQHGHLADEPLFTQLMEHVIVFPKTTWEWWDAEPEREDIMKEVFAEALRFLIVRPKDEPARVGEES
>NC_016935|6455366:6492424|6471727_6473098_-|WP_014371584.1|capsid|DBSCAN-SWA
MTAVARRRLKPLPTRFPDIIARSHAAAVSGLIREMHSGTLDIFNRILKEEARRYQQDSARYDGPLETILATLRLAKDRAKTFIFTPQRITKLAEHFVSRINQYNKRNIGDQVQRVVGIDPTVQEPWLDSFMRASVTENVGYITKIMDDYYAKVEASVLQGVKNGQSLRQLTGKIKKAADVSYSKAKFIAVDQTGSILGQMTAKRHQSAGIRKFKWSTSHDERVRPEHRGYDGKVYEYGKHKLPGTDYRCRCVAIPVFDDDDEDVVAPADSPQETESDIIKNARVFQTADEVKEWEKKVAPAYLKSLNALETSAITKYTGSAYATINKSLRAGNPPDDLVNNISSGLRKFELEEHITVYRGLYSNIFGPVDEMVGLEVTDPGYMSTSLLSSTSFSGTVKMEIKVPAGSRGALVNPISLFQDSEYEFLLDRGSTIKIVEASKDASGVIQILAVVMKNE
>NC_016935|6455366:6492424|6483210_6484194_-|WP_014371604.1|DBSCAN-SWA
MANPQPENGTVRIANELWDEVIRRDFSKRQKDIIFFIWRLSYGCKGQKTAYIPKLVYFELCGIPTGNFHRELDRLEALGVLIRDREKKTFEINKNYDEWKVPLGGGWNEFKFDELLALNLDESRQINAKNRVKTTRKNALKQRDFEGSENEIALKQRDASRQNNANLEGNRVKITHSTPDEPNQDAGSQPPIDIIKDINTDSSSTKILMLNQGTAPAASRSKDFSFSKIYTIYEKHFTENGNVSEFEVQDLTDQFETYGGEWLLEAMREAVRHKIRTLAYINGVLNGYKARGGPHKDKNLQIVGGPADYQLADDDPIAQKLREVYQL
>NC_016935|6455366:6492424|6465694_6466090_-|WP_148279712.1|DBSCAN-SWA
MEGGEQLMPHFDFAEVFGEWGKKFHRFPKGGGYYDYANGGKWVPGYGAPVEMEGIIVPMSFEELQLETGGTYTRDDRKIYVRLPAELAIDDRIMHKGLEYRVLEAKPYDEYSDHRIYIAKRVSTKGRGPDA
>NC_016935|6455366:6492424|6487211_6487505_-|WP_014371610.1|DBSCAN-SWA
MRMATGIVRKVDELGRIVIPIELRRTLQIGLGDSLEVFTSEGEVILRKYSPGCTICGGLGKPMKEYAPFKRICTSCSKAIADDAFYRTDEKIITSAV
>NC_016935|6455366:6492424|6473094_6474465_-|WP_187297971.1|DBSCAN-SWA
MRSSYNAYRNDFLVGHGKGTGKDSLTRQRIATSRKELTEQDLLNYYASSQFVQNLVDIPAEDLTRSWITIRMKDTNLRDMLMRKLRDLSSKERFCDMRRYERLHGDGFVSIGAAQKNDFKLSDPLEENQLLRIDYLHAFSSYKVGNFYLNEDMFSPNYGEVESFQINRRSAIGSQILVGVQDAGVVHRSRLFHDQTRRMEDRYQGQSILEPMWDVLTVFDTALWSVGQILYDFTFKRYKTDGVNQMTREEKYEFQSLADFMFRTEAMAIIGTKEDLDKVTTNVTGINYLLDFVWESLSGAAKMPKSVIKGQEAGTIAGAQYDVLNYYSRIAAAQETELRPHIERLIRYLLISDGELGGKIDPDALEWEVVFNPLWNVDQETDAKIRKMIAEADEIYLQNGVLTDDEVRKIRFGSLDGDAPGVEEAKEPEEPEQKQDGLSEEEWRTLMEGFDKRMKG
>NC_016935|6455366:6492424|6468397_6468880_-|WP_014371580.1|DBSCAN-SWA
MPITSGYDQYMQEPTGKGRVALYPEHRADTVGAAGVVPWGKAVSYTATNQNRGEVYTGARKVAGVAIANHYAENRVTNINNEIVGQYETNDAASILRKGVIWVQVLEDVVKGDLAVADNATGDFRPSTTATTGKSGVLGEFKTSALANGLAQLELNLPNQ
>NC_016935|6455366:6492424|6488051_6488291_-|WP_014371613.1|DBSCAN-SWA
MISTREVSEKLRWLRLKAHYSQEQLADYLALTQSTVSRIENGKQVPDAVTYENWMWVCKNPPKQFQFYYDGGNMQHVGF
>NC_016935|6455366:6492424|6460630_6460801_-|WP_081484367.1|DBSCAN-SWA
MQQLEQKTGEVYATIKSGDSFWRLAGTFKTTTAAIQALNPGVDPRKLQVGQKVRVV
>NC_016935|6455366:6492424|6486920_6487127_-|WP_014371609.1|DBSCAN-SWA
MAKSKVQIRFTTEEKETVEKLHGEKMSASKIAEQLNIIFHKNQPVRKDQSVYYMLKTMKKATETVASK
>NC_016935|6455366:6492424|6474499_6475783_-|WP_014371586.1|terminase|DBSCAN-SWA
MIQVKLSEIVTPHFQSFWKAANSRKYLRHVLKGGRGSAKSTHIALKFIVDMMRYPVTGLCIRRVGRTLEESVFEQLKEAIEILGVSAYWKIMKSPLQLIYLPRGNKIIFRGADDPGKIKSIKVSKFPIAFLWIEELAEFTAEDDISTIEKSVLRAELPDGLFYAFYYSYNPPKRKQSWVNKVYESKVDLPKNTYVHHSTYLDNPYISKAFVEEAEEVKRKRPLKYDWEYLGKAIGSGVVPFDNLVFRTITEEELGRFENIRQGIDWGYGTDPFAFVRWHYDKTRRRIFALDEICGVKMSNREAAERMKFKGYERYMTIADSAEPKSVDQMRDEHSIRIIGAEKGPGSVEFGEKWLDDLDEIIIDPKRTPNLAKEFEDIDYQTDTDGNPKPKLEDVNNHTIDATRYAFEEDMKQGTSSLDNLRRWARR
>NC_016935|6455366:6492424|6488676_6488901_-|WP_014371615.1|DBSCAN-SWA
MKDVQVAWSVVEAKAMVLRTIVGLQTEMDMGYTIEEVVKDLEELLEMLDGIESGARMKGDAISDGAKSTNDLRA
>NC_016935|6455366:6492424|6459432_6460329_-|WP_014371567.1|DBSCAN-SWA
MTQINAFGREVEVLVGDLRFYMDGQSGLDIEFDVPFDDDVIPNEATVTIYNVSSDTYNQISAGQKLIINAGYRGDRGSIFVGEVSEMMPFHEKPDSRIMIKGIDSHVYVEAQLEKTYGPGTTGSTIINDLIRQLGLPIGKIELPDDVTYPRGYSVYGRIVDSLKQVATDCAALAFMARGQVYVCSRFFGEETDFTLSEDTGLIGSPRLTMVDIAKTNLDYVAKQPKTKRKRSTTARVTYGKKDEEQEEQFTVQSLLNHRFGTAKILQVLSVNYNFVYRICRGRHICNDSEFTTEMELM
>NC_016935|6455366:6492424|6465222_6465702_-|WP_014371574.1|DBSCAN-SWA
MLDLRAIRSMIVAGLYAKLQQPVIRADDEGDVPPYPYVVYSLTSPYIDIFGKDIEQVVGENLERVRTVELVASFTVYSEDIDEAEELCMRILDHFNREDREVLAEQGLVVVRISDVQNRSVALVEHYERRYGADVRFRALDWHVGPGEFIEQAEITEGS
>NC_016935|6455366:6492424|6459049_6459433_-|WP_014371566.1|DBSCAN-SWA
MGDFENMLRSMIDRAVLNLHTAQLCRVLSFDSGSLTCDLQPLFQQVRIDGTAFTLPPITNAPCLRQRYRVEGGEVREYSPHYQAGDIVLTVVAERAIDHVLAGQPADPKINRTHHLSDAIVIGVIGG
>NC_016935|6455366:6492424|6488911_6489139_-|WP_041619257.1|DBSCAN-SWA
MEIFERIREVRKSKGVSQTFVAKKVGMTIANYNMKENGKRAITVQELESIAQALDEPVSNFFDENLNVKLNLSSV
>NC_016935|6455366:6492424|6468883_6469996_-|WP_014371581.1|DBSCAN-SWA
MKLQRFDRAMVLDYQEDAAGFLTVRAGITRPGVFPYRRGDGGIQFEAKLPEDILSDAVVQSARAKPVTDEHPPEPVTLDNIQKYSRGMSHTDSRVEDDKIVVTMTVTDRSLIERVRSGKQKEISIGFETDLIQEPGEYMGQRYDAKQTNIAINHIAIVARGRAGPHVAIRGDSAFEIDEEDINEGGQTMAMYTIDGKEFEVPSEVKSKLDVLEARLDAANTKVGEYDKLQGRYDALEAERDTLKGDLENAKKQVLTADKLDAAIAARVALIDGARKFLGDSFDFSGKTDRDVKVAVIQKVKGADFKADGKSDEYIDAFYDASVERARTDGFTSTGANSVITGSYTSDTQDEIAKAKSARLNVKDHWKEGK
>NC_016935|6455366:6492424|6461210_6463292_-|WP_014371570.1|tail|DBSCAN-SWA
MDKYLRKLALSVAWEIEDGPLRKANKAMDELKRRMGDGTARKFERELASAGSKATQSSRSMDKLTSSICQSSSAMDALKKSATGAFQSIQRVTGSATGMLRNTAVGSGVAAAAGATLLASNSMSRAMDFEAQLSSIQALTGLSNEGMKAVEDKALAVGAATKYSALEAARGSEELLKAGMKIERVVSEGLQAGLDLATAGGLSLEEAAATLGRTLNTFKKDGLEAADVANILAGAANTSATSVHELGYALASVGGVQDMTGGNLKDVITAIGLMSNDGAIGGSDPGTSIKSLLLNLQASGDKESGLFDEIGLGNDAKNLFFDNGKIKNLEGIADAIQKVFAPMNDQQRLKMFDEIFGSDGIRAASMLFKNGSEGVRQFQKDMLNVTAYDVAKKKMDNTRGSIEELKGAFETLQIRTLKPFLPFARQLFDGLGNVVERNEDRIVSSANRMADYLREKYIDNQAFRDLSFEAKVDYVFNDIEDTFMAWYNKTGREKAYNISREITSTLATSLAEASGPLTQIGVSLGAGIVKGVAQGVADAAKSVPILGPLVQEVSTGVSDLFQAIGDVKSTYDAAVTMVNNHYNGYGSTANSEAYNAEQMEIGRQFDGSHEDGHPYIPFDGYRAELHKGERVLTAEENRAYNSGQTPSGGMQLPPIVQHFHGNTSREDAYNGTMAALDAYARSIMRRDPQPVVR
>NC_016935|6455366:6492424|6480238_6480910_-|WP_014371598.1|DBSCAN-SWA
MVAAKGKANIGGITVGSKNVKIVLEISKRDFFKNAKFFESDPEEVDFVLGDMQMSISDYLASSSAPHQGLKAVVDRSGVVQSAEDGNQATILDQPDDSQENLQADQAAPNPDLELSFEDGYAPAADEQSADEGGTADGAYAADEDQGAGPDPSKEEVENHILQEKPRFDDVEFDPALFVEKIETNCSWMEIASKHGLSSTQLQASWGKYKKRVAQKLKRNGAA
>NC_016935|6455366:6492424|6466068_6466686_-|WP_041619526.1|DBSCAN-SWA
MTIKDTNRIPDVIRTIRALNSKAIEIGVFGSDDSFMAMLASVHEFGLTINAKKRFLTIPTALAGDKTAREFNDLRFVPIDGGRKGLLVRDRQRSGKVGARSEIMFILVPSVKIPERSFIRSTTDAKQAEWNKLAGRFLADVLDGKMSVETFYERLGARIVGDIQETMRDMEPENAPITRSRKKSSSPLIDTGRLRQSVTWKVVSS
>NC_016935|6455366:6492424|6481933_6483211_-|WP_014371603.1|DBSCAN-SWA
MLQTEALEMVILGTVFEDPSLAREVLNTVTIDMFRQPWNRNLYRMMSWLDKNGHPVNYTNISTYFAKDVAKIGGVDYLLKVIGSVVSVSEIRQNMKLLAELDARRKLSQLIDQTRTLIDDPAAGRFDEILDTFEQKALEIRPKVSQENKSGDRIRTWFENLLLRKQNPKIAFGILTGWEKLDQMTLGFQRSNLIVVGARTSMGKSAFANEIKVRASSRGNRVADFSLEMTIEQIYNRMASSMCGIPLQAIRIGNLTDFQIGQIADKLDEFAKIPIDDSRGVTTEYITSEMRRMKRQEGLDLVVVDYLQEINETAEQNDNGGSALHRVCQKLRAAAKDCDCAVIGLSQVKQDVDSRANKRPMVSDLSGSAAIAAVADDIILLYRDEYYNPETSDKGILEVNVAKQRNGPTGTVKLNYDKDTQKITG
>NC_016935|6455366:6492424|6470070_6471081_-|WP_014371582.1|DBSCAN-SWA
MANKIGRNDLCFCGSGLKYKRCCINKKQEKRKYLAEFALHTYSSHASIFYPNDMGNFDFSNFKYHIYMINLIPRLTFVKDTLRVAEEAISVAVRVQTETADYVEDFNFKFKSSIDHRTLNIEFDKPLRSIQITDSQGKGTIFRVLPFYLRNTPGKIDCEILYIGQSFGKEGERQALDRLKSHSTLQEIQSDLLFNGTVRDLAISLWEFTPKLFSLFDGKSKVYDVSESEDIQHMMQIIKDPPLHINKQIINITEAALINYFKPEFNDKLKNNFPDVNHSGYKEYYDLDYNSLIVEIDPETISANMYTKEKNYNILKPIQYGLHPENVRKSMFEIFE
>NC_016935|6455366:6492424|6455366_6456866_-|WP_014371562.1|DBSCAN-SWA
MAFNSPLAEWYASGVEPPEDDKTIGHKIDDPLPANWLNWQWHRTYAALDELQKNAVHKSDFDQSLKKADAVQFSGLTVTRDADNAFLTVKATGASGHDVVLNMENETMGTDKYRIKQIFNTANDGMGGEGFLFRAVRPSDGRTVDWKLSGNTGDIWTSGRNLNLGTGYSLNLNEGPLYLRSTNGADTNHFIRYFDETSTKNIDGTRIAGNRGVQLGTMDHGATNGGVFHPTVTIANDFYNISLDVRRQPGRQIQADTFIGVPAGVKLGAYIVNYEDSTSSVGAIVANRYANDDTSIFEAVSLFNGWNPMFSVRGRGQVNVFGKTFLHNGAAQNPMNSAPAISVAIGDHDTGFNWNSDGQMEIFANNQVTAWWNTTQFRVEKAFSVGGTKSAFVQTASHGEQLLYAMESPENRFEDFGEGQIGDDGSVVIQMDPIFLETVEIYGDDYQVHVTGIDGNGFTVPVRGADSFTIHGPAGKKFMYRVLAWRLGYHNLRFNYAAG
>NC_016935|6455366:6492424|6467071_6467485_-|WP_014371578.1|DBSCAN-SWA
MLVHNKGNYVRNQNGVRLVPGVNNISDEDWADFIAHPLNQRLVDEGEIVPQIRTVERIEGNQVTREQKTAGLADMTAAEVASLVKDTFSRELLGDLRDEEAAGQNRKTVLAAIDKQLEDIEKSFQEAREKEAKKANE
>NC_016935|6455366:6492424|6464200_6465217_-|WP_014371573.1|DBSCAN-SWA
MPLKDVKVTISLSRPAGLIGFGKPLIIGPKTGGQAYKNYSDLTALVADGFAVGSEVYKAAAAVMGQGDNRPQVFAVAAYDSGSTSDALDVLTANYSKDWYFLISTSTVKAEVIELSNYVEGQGRKLFVTRTSNLTDLVDLKATGNELTFVMYHSDPDEVAKYPDAAWVGRVGSRTVGTVTWKGHRLVGILPDDLDAAGLQDVHDNGGNAYVTKAGTPVTSEGQVLTGEYIDVIMGNHWVAANIEEQVQALFNSGEKISYTNGGISQIESVVRTVLGIAYRQEIIAEDADGIPLYSTDFPSRAETTTIDRAERILRNAKFKYELAGAIHAAEITGTVSA
>NC_016935|6455366:6492424|6489679_6490744_+|WP_014371617.1|DBSCAN-SWA
MDNRDLGKIEHSPIKTNVQIKESKQPIKTPGCMSFLVWSSIIIVVLILIALRNEDEKKTVTQSITNTKVEQARKNLDPTTQRLISFNVTPHESVVRYGQQLKYSLILKNEGDHTINGANISVDGDWYKYSNISLSENAKLENGILSDKIIYSDKIEPQQQVTIEFTGTVNDGTEIDPAGFICQFIPTTTFDNRKFVGDVDKQTLQVYILPEKQGAENVNVSVSEAKRELANYTPAMIDFNLETKINTLSSGEKAELVLNIENKGDRPIEGLYMYASNDFSYLENLQVSSGQIEPGLLTQTIKIENVINPNTSMTLTITGTLNKITKEKLKLTVSPGRSVNGEEVIVLGDSEKKK
>NC_016935|6455366:6492424|6458681_6459053_-|WP_014371565.1|DBSCAN-SWA
MKSFKLGEDGDLVIQDGELLMVEGDEELLQCIRIEFSTYKGEWFLDSNMGVDYYGKILVKSPNYAVIKAELTAAILREPRIRTVDQIEFVNFDRAKRVLSIKFKATAWNGRTLESSEVIPGAG
>NC_016935|6455366:6492424|6478905_6479259_+|WP_014371593.1|DBSCAN-SWA
MKKKALMLMTVVAAVLSFSTSASAAYSKVFGPQDLQGVVYLEGGVSNPTSTKAYINFKLWQVTPSGDVLIRRDLLGLDAYSSAHFSESSVVSLPWGTYKYEIVAKDGVRASGVMGAR
>NC_016935|6455366:6492424|6485931_6486804_-|WP_014371608.1|DBSCAN-SWA
MQALKLARVKDMPKEDWLEFRRKGIGGSDVAAICELSKYRSPMAVYLDKIGELPPLEDNDKMKAGRMLEPLIAKWFTEETGIRVMQQHSIFQHREHDFMLANIDRWVIGKNEGLEIKNTSEYNRDEWTGEKVPVEYMLQCNHYMAVTGAVRWYVAVLIGGWDFQWRVIERDEELIGNLIEIEYNFWNNHVLAKQPPAYGHQDTGLLKDRFPESRPGSNIELGEENYDLMRMVLDSKKALKHAEETHETAKNRMKAVMADHEMAWFQGEPVFSWKSNKKGVRSFKIVGGDE
>NC_016935|6455366:6492424|6478154_6478526_-|WP_014371591.1|DBSCAN-SWA
MSQIKIKRGTYQHVEDELREYHETRKEIIRIKNELLQDQTGCPGTLIMQYRKHDEMQRIIDAIDGVVLRLPADKQELIKLRYWTRPQLLTWEGIAQKLYCTKRTAYRWRDEIVEDIANRLGWW
>NC_016935|6455366:6492424|6456881_6457520_-|WP_014371563.1|DBSCAN-SWA
MSFWEQMRKRLTDVFKKNPESNISKFLRLAAEPMDEIEAVLWQIHAWRDLDQAEGTTLDLIGSNVGQPRGVVSDPIYRALIRSKIARNLSTGTLDSIIEVLALALDSDPSTIKLEELSEDEVDPKPAAIRVAGLPYNRLDTMGISTTQFLQLVKSVVSPGVQVESIEFSGTLRLSDVGAAKRPGLGLGDDAKTTGGTLGNVYAGDDTPELPI
>NC_016935|6455366:6492424|6467484_6468381_-|WP_014371579.1|DBSCAN-SWA
MMNQVAFRGMDLEAIDRRLYELKYEELTARRILNLKTDIPAGAETYAYDVMTRSGVAKILANNADDVPFVDVDTRREFQRIYSIVAGFAYTVQEQRAAQMTGQTIDSTKAGVARRAVAEKENRLAWIGDPDFNIPGLINATGIQTTNVPPRADGTSTKWKDKTGEEIVEDVRIVRSLVSVLPGHMTAPLALALPPNQFEILNSRYNEYDSRTVLQVIQSYNWFRSIDRAPELRGAGTGGTDSMLIFDASSEVMELLLPMDMMRHDPEWEFPKWKFVVEERCGGVVIRYPMAIARGDGI
>NC_016935|6455366:6492424|6460325_6460631_-|WP_014371568.1|DBSCAN-SWA
MYRLNINKAAVPYRFEVVIANVRYQWEIRYNDMFDFFTVDLSTGGEVLVVGEPLVYGSSLFQSMGDERFPRFTITPLDQSGIVETVTWGTLQETVFLEVEP
>NC_016935|6455366:6492424|6490843_6491332_+|WP_081484347.1|DBSCAN-SWA
MNLTKYQTTHLEDFVDELYRRLNVSSPEQLTVEYISTALGIRVDYAPISCSDECGGRFIIYLNFNLPPSDHFKEFLHELGHAMRHEGNQIHMHPLMREWQEWDAENFVLYASIPFLLLRIMELPRDQHSAIELIATTFRVDPEMAHTRYHQILRRIYCSMWR
>NC_016935|6455366:6492424|6489298_6489670_+|WP_081484346.1|DBSCAN-SWA
MSLGSRLKSEREKRGWSQLLAAEKLGITNAVLSNYERDYRDPDTETLKKMADLYEVTTDYLLGRVEAEKPNTYEDPLEDPYRSIHFNGWDKLSPEDQEEIKAFFRAKIMIREAEERNKRNKKN
>NC_016935|6455366:6492424|6479488_6479911_-|WP_014371595.1|DBSCAN-SWA
MNPQITKNEVDVLEALRIHGTTKGVLSATGYASFTVYTHLRTLMKLGLVSRSGVKGSYRFKALDGEYEIRGNRGRPKPAPDHEEGSDSLIELSLNVDLNEDQKFYLAAHRRSTSRRVLAERLGLTKLQLNFLLMKIGGRP
>NC_016935|6455366:6492424|6475769_6476294_-|WP_014371587.1|terminase|DBSCAN-SWA
MALTAKQQRFVEEYLIDLNATQAAIRAGYSVKTAMEQGHQLLQKTSVQEAIAKAQAERSKRTGVTADRVLQELAKLAFAKMSDFAEWDEDGVSFKSSDKLSPDDAACIAEITEQELEIAGGNVRRTKKLKLHDKSAALEKLGRHLGMFKDNLNINANVGVQIVDDIGGGMDDPG
>NC_016935|6455366:6492424|6485029_6485929_-|WP_014371607.1|DBSCAN-SWA
MAAPAKATDQKDLSKALANKAAAGNGQGKTIAQLFDEMKPAIAQAIPKHLTPERLLRIATTSIRTNPKLKVCTPESLLGAVMQCAQLGLEPSILGHAYLVPYRNKKKEGNKEYFVDEAQFQIGYKGLIELARRTGHISSIMSQAVHEKDLFEYEYGINEKLRHVPADGDRGPVTKYYAYAKFKDGGYSFMVMSKRDIELHRDKFSKAKFGPWVDHFDEMAKKTVLKALMKYMPISVEFQKAVSMDETTKREVSDDMSEVIDVTDWSESSAEDAGGGDEQRDPDTGLLNDRPPDDQVEFE
>NC_016935|6455366:6492424|6471223_6471511_-|WP_041619253.1|DBSCAN-SWA
MIKHDFSIEGAREGGDYVVREWINGIGSEVARIPEAKMGGLKASRQKIGEILKLRGISKSALVTHRCIVPGRGGNPVHKWTVDQYLIGVPEKKKN
>NC_016935|6455366:6492424|6484218_6484833_-|WP_148279756.1|DBSCAN-SWA
MLNDVTVFDFETSGLDSKNCRVIEMAAIRCINGEIVSQFDTIVRQDFPGGLDPKIIDLTGITPYMLSTGMNELLAFKILKNLIGESLLVAHNAAFDLAFLHHSLMRLAGKTYGNSFIDTCTISRDRHVYPHKLTDMCDRYDIALSGAHRALNDVLATWDLLKALDAEGSVSGYVNRLGYLDKYGPPSWAPEHATLVPMKNRYAG
>NC_016935|6455366:6492424|6480916_6481405_-|WP_014371599.1|DBSCAN-SWA
MPRYVGLDPSTKTGFVVLDEDGEIWEARELEGKGENPGRMHDLICQVGLLIQPGDRVAVEGFGFASQRGFELGGIGWGIRLNLFARKIGYTEIAPSQLKKFTGSGGNAGKEEVAVETYKRWGFQHKSNNVTDAYVLAQIVRAMHEPVKLIKVQQEVIQKLRG
>NC_016935|6455366:6492424|6481397_6481583_-|WP_014371600.1|DBSCAN-SWA
MDPTMRAIIRRIIDDLETKARQLQVPNMHGASGEYVEGFKTGKSAGLFQASMELEKVLQDA
>NC_016935|6455366:6492424|6488432_6488711_-|WP_014371614.1|DBSCAN-SWA
MAQNQPTIYEHKVMELLGNLAEMLLKKEQPREPFADYPDLLSANDIIEMTRWSTSHTYSVMNRPDFPLANGGEKPYCVLKVDFINWLKREVP
>NC_016935|6455366:6492424|6466694_6467057_-|WP_014371577.1|DBSCAN-SWA
MPTTPDRVRAIASHLGALTDPQLQLFIDDAIIEIASFPAEKIAGYEERLPRYLAAHLASMNVRRSTSQQVGDMKVTYDSGTGAKGEGLASTPYGQEYLRLLDLLDLKPPETGPGLGLMVL
>NC_016935|6455366:6492424|6463783_6464188_-|WP_014371572.1|DBSCAN-SWA
MKNVSTFNAKDVAITVNNIFLTGVAEDSFVTASKDEDEFTTSVGAQGDVSVSEVNNPLGTITVTLQQSSPYVEYLNRLAVSKTMVPIWVFYNGRPKEKIGGTQARIKRPAAVNYSDDATDSNRSFEFQVFDYTQ
>NC_016935|6455366:6492424|6479318_6479492_-|WP_014371594.1|DBSCAN-SWA
MNNDQVQELKEGLQVIISQGIVLQLVKVSELREMAETIERQAEQIASLLHELKHLSK
>NC_016935|6455366:6492424|6479913_6480072_-|WP_014371596.1|DBSCAN-SWA
MKQGTRPTRRQKIVIAKVKLNPENWLVERETPEELVIMHRNTSTVKRIWKGA
>NC_016935|6455366:6492424|6480084_6480234_-|WP_014371597.1|DBSCAN-SWA
MSSFPYEERILELKEHEQEIIVIKGRAFIITPATLDDVERITSGMICID
>NC_016935|6455366:6492424|6491338_6492424_+|WP_014371618.1|integrase|DBSCAN-SWA
MAVKLKGTIRERGDKFEYVIDVGRHPVTGKRMQETGTRATYADAEQALIEINRNIQLGQNIRSVTLGEFITRYYEEVVKYDVRPPTFHQQMHMVSLIIPKLGDKRIDKISYDDIENLYKKLLDEGRGKATIKNVCMVLRKTFKHAMIKRLIMYDVAKEVKPFAYRPPRMNVWLPEQVNHFLMTMKGTERHAFYSLAFSTGMRIGEITGLYHSDITPQTNEVHVRRALKKLRGVGLVFDDPKTENSIRSIEIHPKLTQLLLEIKPKPGTPVLFTNRVNKPMDPKAVREVFQKDIAASKLPPIRFHDIRHTVATTLLASGIPVHSVAEILGDKVETVLTTYAHVLPKMRTEAAHSIHRSFFEI
>NC_016935|6455366:6492424|6477200_6477812_-|WP_014371590.1|DBSCAN-SWA
MSGDRFILWMARIFIFIMVCISTLILIILLKELGPAIPSNWDPLAFIGAIVGGFITLFGVRITIKNQRSADFLRDYLKVRTNGDDVHGELDAMTRVIKEYLFGDKYEIHNKIVGVSLAVEDILKGKDALKEKAALVSEKFYDMTDVYLLTISHWKYFLKYENGLDENYLYEKFKREYQQLLAAVMVLEDQMELIREKYKKLSK
>NC_016935|6455366:6492424|6476844_6477090_-|WP_014371589.1|DBSCAN-SWA
MNMKVTYHDNEGGGEIFAEECDNVAELLAFLKEHNEVNLRWPDKDSFWQGRFYNAILDIEVDEEGNSVKTLMVFLEHINSQ
>NC_016935|6455366:6492424|6457516_6458692_-|WP_014371564.1|plate|DBSCAN-SWA
MLDSSGFKRKTYADLLAEGEAKARELFGEDINTSRMSPVGIVLRVFAWFLSVLWMVAEKVYLSAFVDTAEGVSLDRLGVQAGVRRIVDTYASGPVELTGTAGYMVNPGLLAQKPSGTQYVITNAVTLGGNGKGITTVQAVNPGSSGNADVGEISVLVNPDANLTAITNLEAIENGADRESDAAFRARFRTSRAARGSATLNSLQASVAALPGVRAVKVVENEEEVPDSEGRPPNSFETYVLGGEQAAIARAIFDNKAGGIRTWGSITQQVADISGTLRTIRFSRPTTVPIFANLQVETNSSAASNVADQVKDAIVQYIGGETADGTVYAGGTMGEDVLWAKIIRAAYTVTGVENVHGGIGTTAGSYSTNDIGIQEQQVAQINAADIGVTVA
>NC_016935|6455366:6492424|6481582_6481744_-|WP_014371601.1|DBSCAN-SWA
MRKVSDPLFQVTHRFVIYEGKEQLGAVYVLADRFIFAPKKARRGLRCVKAVGY
>NC_016935|6455366:6492424|6463291_6463471_-|WP_148279711.1|DBSCAN-SWA
MSQQEWEKKAERNWLFWRPVLETGGISYSEAFAMDMDELNEANAAVTIWQRLKAKRGDF

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014371562.1|6455366_6456866_-	hypothetical protein	D2IYX8	Enterococcus_phage	1.5e-13	31.6
WP_014371563.1|6456881_6457520_-	hypothetical protein	A0A1L2JZ80	Aeribacillus_phage	1.9e-42	41.1
WP_014371564.1|6457516_6458692_-|plate	baseplate J/gp47 family protein	A0A1L2JY69	Aeribacillus_phage	1.1e-85	43.3
WP_014371565.1|6458681_6459053_-	DUF2634 domain-containing protein	A8ATI1	Listeria_phage	3.4e-12	36.1
WP_014371566.1|6459049_6459433_-	hypothetical protein	NA	NA	NA	NA
6459149:6459164	attL	NA	NA	NA	NA
WP_014371567.1|6459432_6460329_-	hypothetical protein	A0A1L2JY62	Aeribacillus_phage	1.2e-34	33.0
WP_014371568.1|6460325_6460631_-	hypothetical protein	NA	NA	NA	NA
WP_081484367.1|6460630_6460801_-	LysM peptidoglycan-binding domain-containing protein	NA	NA	NA	NA
WP_014371570.1|6461210_6463292_-|tail	phage tail tape measure protein	A8ATA7	Listeria_phage	4.0e-41	34.3
WP_148279711.1|6463291_6463471_-	hypothetical protein	NA	NA	NA	NA
WP_014371571.1|6463439_6463739_-	hypothetical protein	NA	NA	NA	NA
WP_014371572.1|6463783_6464188_-	DUF3277 family protein	A0A1L2K2P1	Aeribacillus_phage	7.7e-26	49.2
WP_014371573.1|6464200_6465217_-	DUF3383 family protein	A0A1L2JZ70	Aeribacillus_phage	8.0e-72	44.6
WP_014371574.1|6465222_6465702_-	hypothetical protein	A0A2D1GQ35	Lysinibacillus_phage	1.5e-07	31.8
WP_148279712.1|6465694_6466090_-	hypothetical protein	A0A1L2JY57	Aeribacillus_phage	4.0e-11	33.6
WP_041619526.1|6466068_6466686_-	hypothetical protein	A8ATG9	Listeria_phage	5.3e-34	43.8
WP_014371577.1|6466694_6467057_-	DUF4054 domain-containing protein	NA	NA	NA	NA
WP_014371578.1|6467071_6467485_-	hypothetical protein	A8ATG7	Listeria_phage	7.6e-13	39.4
WP_014371579.1|6467484_6468381_-	DUF2184 domain-containing protein	A8ATG6	Listeria_phage	7.3e-77	50.5
WP_014371580.1|6468397_6468880_-	hypothetical protein	NA	NA	NA	NA
WP_014371581.1|6468883_6469996_-	DUF2213 domain-containing protein	A8ATG4	Listeria_phage	6.7e-72	52.6
WP_014371582.1|6470070_6471081_-	SEC-C domain-containing protein	NA	NA	NA	NA
WP_041619253.1|6471223_6471511_-	hypothetical protein	NA	NA	NA	NA
WP_014371584.1|6471727_6473098_-|capsid	minor capsid protein	A0A1I9SES4	Klebsiella_phage	1.3e-13	30.6
WP_187297971.1|6473094_6474465_-	DUF1073 domain-containing protein	A8ATG1	Listeria_phage	5.0e-109	47.4
WP_014371586.1|6474499_6475783_-|terminase	PBSX family phage terminase large subunit	S5MC58	Brevibacillus_phage	1.8e-193	76.6
WP_014371587.1|6475769_6476294_-|terminase	terminase small subunit	A0A2K9V3C4	Faecalibacterium_phage	3.4e-26	47.4
WP_014371589.1|6476844_6477090_-	hypothetical protein	NA	NA	NA	NA
WP_014371590.1|6477200_6477812_-	hypothetical protein	NA	NA	NA	NA
WP_014371591.1|6478154_6478526_-	hypothetical protein	A0A2I7SC40	Paenibacillus_phage	9.2e-34	49.6
WP_014371593.1|6478905_6479259_+	hypothetical protein	NA	NA	NA	NA
WP_014371594.1|6479318_6479492_-	hypothetical protein	NA	NA	NA	NA
WP_014371595.1|6479488_6479911_-	hypothetical protein	NA	NA	NA	NA
WP_014371596.1|6479913_6480072_-	hypothetical protein	A0A1C8E9A0	Bacillus_phage	2.9e-05	45.8
WP_014371597.1|6480084_6480234_-	hypothetical protein	NA	NA	NA	NA
WP_014371598.1|6480238_6480910_-	hypothetical protein	NA	NA	NA	NA
WP_014371599.1|6480916_6481405_-	hypothetical protein	A0A0C5AFC9	Paenibacillus_phage	3.9e-32	48.3
WP_014371600.1|6481397_6481583_-	hypothetical protein	NA	NA	NA	NA
WP_014371601.1|6481582_6481744_-	hypothetical protein	NA	NA	NA	NA
WP_014371603.1|6481933_6483211_-	AAA family ATPase	Q38152	Bacillus_phage	2.1e-45	30.5
WP_014371604.1|6483210_6484194_-	replication protein	W8EKA2	Geobacillus_phage	4.5e-27	49.2
WP_148279756.1|6484218_6484833_-	3'-5' exonuclease	M1I8M0	Bacillus_virus	4.0e-18	38.2
WP_014371607.1|6485029_6485929_-	recombination protein RecT	W8EBF6	Geobacillus_phage	2.6e-66	54.5
WP_014371608.1|6485931_6486804_-	YqaJ viral recombinase family protein	S6C475	Thermus_phage	9.6e-66	45.7
WP_014371609.1|6486920_6487127_-	hypothetical protein	NA	NA	NA	NA
WP_014371610.1|6487211_6487505_-	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	A0A2I7SC16	Paenibacillus_phage	4.4e-15	48.1
WP_014371613.1|6488051_6488291_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_014371614.1|6488432_6488711_-	hypothetical protein	NA	NA	NA	NA
WP_014371615.1|6488676_6488901_-	hypothetical protein	NA	NA	NA	NA
WP_041619257.1|6488911_6489139_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_081484346.1|6489298_6489670_+	helix-turn-helix transcriptional regulator	A0A2P1JU09	Anoxybacillus_phage	7.3e-15	61.2
WP_014371617.1|6489679_6490744_+	hypothetical protein	NA	NA	NA	NA
WP_081484347.1|6490843_6491332_+	ImmA/IrrE family metallo-endopeptidase	NA	NA	NA	NA
WP_014371618.1|6491338_6492424_+|integrase	site-specific integrase	A0A173G9H3	Propionibacterium_phage	4.2e-18	23.7
6493874:6493889	attR	NA	NA	NA	NA

Sequences of DBSCAN-SWA_4

Nucleotide sequences of DBSCAN-SWA_4

>NC_016935|8085654:8095019|DBSCAN-SWA
ATCATACTTCCGCTCCTTCGAAGGTAACGATCCCTTCGCCGGTTGTAATCTCGCCCAGGCGGTAGATGCTCTCGCCAAGCTCACGTGCCGCAGCAAGCGTCGCTTCCGCTTCTTCGGCGGAGACGACGATGACCATGCCGATGCCCATGTTGAAGGTACGGAACATGTCATTGTTGGAGATCGAGCCATCCTGCTGCATCAGGTGGAAAATCGGCAGAATCGGCCAGGAGCCGTACTGGATGTGGGCATTGACGTTCTTCGGCAGTACACGCGGAATGTTCTCCAGGAAGCCGCCCCCCGTGATGTGGGCCATCCCTTTGATCTGCACTTTCTCGAGCAGGGAAAGAATCGTCTTCACGTAGATCCGAGTTGGCTCGATGAGCACATCGCCGAGCTTCTTGCCTTCGAGTGCTTCCAGAGCCTGATCCAGCTTGTAGCCCTTCTGCTCCAGCAGCAGGCGGCGGACCAGCGAGAAGCCGTTGCTGTGAATGCCGCTCGACGGCAGGCCCAGGACGACGTCGCCCGGACGGATCGTGGAACCGTCGATGATTTTCTTCTTGTCGACGATACCGACCGTGAAGCCAGCGATGTCATACTCGCCTTCGCTGTACATGCCCGGCATCTCCGCCGTTTCGCCGCCGATCAGCGCGCAGCCGGCTTGTACGCAGCCGTCGCTGATGCCTTTGACGATCGCTTCGATTTTCTCCGGAATGACTTTGTCGCAGGCCAGGTAGTCGAGGAAAAAGAGCGGTTCCGCGCCCTGCACGATAATATCGTTGACGCACATTGCTACCGCGTCGATCCCGATCGTGTCATGCTTGTCCATGGCAAAAGCCAGCTTCAGCTTCGTCCCTACCCCGTCCGTACCGGACACGAGGACCGGCTCTTCGTACTTGTCTTTGTTCAGACCGAACAGGCCGCCGAACCCGCCGAGCTCGGTGAGCACCTCAGGACGGAACGTGGTTTTGACGTGTTTCTTCATGCGTTCTACCGCTTCGTTGCCTGCCGCGATATCCACGCCGGCTTGTTTATATGCATCGGACACTTGGTTTTCCTCCCCGGAAATGGTTGACCCCTGGGCTAGTGCGGGGCTCCGGCATCGTATGATTTGCCTTCGGCCGCTGTTGAACCGGAGTTCCTAATGAACTTACCTGTCGGTAAGAACTCCGGTTCAAAGGCGGCACGTAAACTCTCCGGTAAACATACGAGCCTCCCGCCCAAGCCAGTTGGGTCAAAAGATTTACGCCTCGAAATACGGCGTTTGGTTAATGATAAGGCGGCCGCGCTGTGCGGCGGCCGCTCGGTTTGTTAGGTTGGTTGAACTCGGTGCATCCCTTACCGCTGCTGTGGGTCTCATGAAGCCGCGGCTGGGAAACCACTTATATCGCATCACCAGGTAGCCTTCCGCGAATGGATCACACAGTTGTGCTGCTCGACAGGCCTATTTCAGTTGAGACACCACTGACATCCAGCTCGAATGCCTTCCGCGGCTGAGACGCCACTGTCGTGCACCACGAACGAGCCTTCCACAGATGGACCATTATTGATGTTCTGCTGGGACGGGCCCTCCGTAGGGGGGACGCTACTTGCACGCTGTTCGGACGAGCCTTCCGCGGCTGGGATGCTACTGTTGTGCAGTTCGGATGCCCTCATAAGTACTTTCCGCGTGTACCGGCTTATCCCATCAAGAAGGACATACAGCAAAATAGCGGAACTGAGATTCCTTATTCGCCCGTTTCCAGGGTACATTTCCGGAATAACGGAACTCAGGTTCCTTATTTGGCTCCCAACGGCCTCTTCGGCTCGCCACCGGCCCAAATAGCGCATCGGAGTTCCGCTATTTCGACCAACACACTCGCCAATTGAGCGAATAGCGAATCGGAGTTCCGCTATATTGCCAATGTCGCCGGTTGCCTGCCATGCATTCCATGCAATGCACGCCTTTCGCAGCTAGCTGACTGCACAACCGCATCACATGCAGTCGGTCCACTGAGGCAGCTGGAAGCCTCCGTGCATTCAAAGCAGCTAACAGCCTGCCTGCGGCCTGCGGCCAAAACAAGGCTTCCTGGCAGCTCTGCAGCTGCGGAAGGACAGCCTGCCTTTAACCCTCGGCTAACCGGTCCGTCTCACCGCCAGCGCTGTGAGAGCCCACTCGCTCTCCACCGCAGCCTCGCGGCCTACGGCCTTCAAGCCCCCAGCGCTATGCGGTGCGACTTCCCGCCGCTCTCCCGCGCCGCTCCCTGCAGGCTACTTAATCGCAGCCGCAGCCGATCTTCGCGTCGTCCGGGATGGCCGTCGGGTAGCGGTTGTCGAAGCACGCCGTGCAGTGGCCGCGGTTGATCTCGCCCGCCGGGCCGCCGATCGAGTTCACGAGCCCTTCCTGGCTCAGGAAGTGCAGCGAGTCCGCGTTGATCGCCTTGCGGATCTCCTCCACCGACTTCACGGCGGCAATCAGCTCGCCGCGGTTCGGGGTATCGATCCCATAGAAGCACGGGTTCTGGAACGGCGGCGAAGAGATCCGCACGTGCACCTCGGTTGCTCCCGCTTCGCGGAGCATGTTCACGATCCGCAGAGAAGTCGTGCCGCGCACGATCGAGTCGTCGATCATGACGACTCGCTTGCCATGCACGATGCTGCGCACCGCGGACAGCTTCATCTTCACGCCCTGCTCGCGCAGCTCCTGGCTCGGCTGGATGAACGTCCGGCCCGTGTAGCGGTTCTTGATCAGCCCGAGCTCGTAAGGGATGCCCGTCTGCTCCGCATACCCGATCGCCGCCGAGATGCTCGAGTCCGGCACGCCGGTGACGATATCCGCGTCGACGAACGACTCGATCGCCAGCTGGCGCCCCATCCGCTTGCGGGCGGAGTGGATGTTCACCTCGTCGATGTCGCTGTCCGGACGCGCGAAGTAGATATACTCCATCGCGCAGACGGCCCGCTGCTTGCCTTCGGCGAAACGGTCGTGCGTCAGCTCGCCCGTCCGCTGGTTGAGAATCAGCAGTTCACCCGGCTGGATGTCGCGCTCGTACAAACCGCCGACCGTATCGAACGCACAGGACTCCGAAGCAAACAGATACGCATCGCCCAGACGCCCCATCACGAATGGCCGCAGGCCGTGCGGATCGCGCGCCGCGATGAGCTTGTCCCGCGTCAGGAACAGGAACGCATATGCGCCTTCGATCTGCAGCAGCGCGTCCCGGACCGCTTCGACGATGTCATCGTGCTTCGAGCGGGCAATCAGATGCGCCACAACTTCCGTGTCGCTTGTCGTCTGGAAGATCGAGCCTTCCCGCTCCAGGCGCTTCTTGATGTCCGGCGCATTCGTCAGGTTCCCGTTCGTAGCGATTGCGAGATCGCCCTCGCGGTACTTGAACACGAGCGGCTGGGCATTCGCCAGCTTGCTCTCTCCAGCCGTCGAGTAGCGTACATGTCCAATCGCATAGGAGCCGACCATCGGTCCCAGGTTATCGTTGTTGAACACTTCCTTGACCAGACCCATGCCGCGGTGATAGTTGAACGCATCCTCGCCCGCCACACAAATGCCGGAACTCTCCTGCCCCCGGTGCTGCAGGGCATGAAGACCGTAATACGAAAGATTGGCGGCCTCGGGGTGACCGAACACCCCGAATACGCCGCACTCTTCTCCCAGCTTGTCGGACAGGCCGTTCGGACCTGCCCCCATGCCTTCGTTATAATACGCTCCGGTCCAGAGAGGGAACGCACCATCATGTTGCCCTTGACCATTGCCGCCTTGCCGCATTCCCGTCACCAGACCTTTCGCATCCTCATTCATATCTAATCGTTCCTGTCCGGAAACTACGCGTTCATCAGACATGGAATCGCATCCTTCCAAACTTGCTGCAGCTCAGCCACAGCAGCGTCGATTGCCGCGCTGCCGTTTACCTGCACCTGCAGAGACGTGCCTTCCACCTTGCCGATGACCTGTACAGGAACGCCGGCTGCCTTCAGCACCGCTTCCAGCTCGGACGCCTTCTCCGGTGCCGCGCTGAGCAGCAGGCGGGATTGGCTCTCACTGAACAGGGCGATATCCGCACGCAGGTCCGTCGTCAGGTTCACGTTCGCGCCCAGACGGCCGCTGATGCAGCTTTCAGCCAGCGCTACAGCCAGACCGCCGTCGGACAGGTCATGCGCCGAAGCGACGAGACCTTTCTGAATCGCACCCAGCACCGTATCCAGCAGCGTCTTCTCCACGTCGAGGTCGATCTGTGGAGGACGGCCTTCCGTTACGCCATGAACAACGTATTGGAATTCGCTGCCGCCAAGCTCCGCTTTCGTCTCGCCGAGCAGCAGGACGATGTCGCCTTCGTTCTTGAAGCCCTGCGTGGTGATGTGGTCCGTGTCATGCACGAGACCCACCATGCCGACAACCGGTGTCGGATAGATCGCGCCGCGCGCGTTCTCGTTGTACAGCGACACGTTGCCGCCGATGACCGGCGTGTTCAGCTTGCGGCAGGCTTCCGCCATACCGTCCACGGACTTCTCGAGCTGCCAGAAGATCTCCGGCTTCTCCGGCGAACCGAAGTTGAGGTTGTCCGTAATCGCCAGCGGTTCCGCACCGGAGCACACATTGTTGCGCGCCGCTTCCGCCACGGCGATCTTGCCGCCGACTTCCGGATCGAGGTACACATAACGGCCGTTGCAGTCCGTCGACATCGACAGCGCCTTGCGGGAGCCGCGGATCGTTACAACGGCAGCGTCAGAGCCCGGCTGAACTGCTGTGGAGGTACGAACCATGTAATCGTACTGGTTGTAAACCCACTCTTTGCTCGCTACCGTAGGCGAAGCCAGAACCTGCTTCAGGGCACCGTTCAGATCGGTAACTTCCGGATAAGCGGTGGTATCGACCGAAGCATTCGCTTCGTAGTAAGCCGGTACCGAGGAAGGCTTGTTGTACATCGGGCACTCGTCGACCAGCGCCGTCACCGGCATGTCGCCGACAAGCTCGCCCTTGTGGTACAGCTTCAGGTTGCCGTCGTCCGTTACCTTGCCGACCTTCGCGCAGTGCAGTCCCCAGCGCTCGAAGATCGCTTTGGCCTGCTCCTCATGCTCCGGCTTCACGACGAACAGCATCCGCTCCTGGGACTCGGAGAGCATCATCTCGTAAGGCGTCATGCCTTCCTCACGCTGCGGCACCTCGTCGAGGTACAGCTCCATGCCGTTGCCCGCTTTGCTCGCCATCTCGGACGAGGAACACGTCAGACCCGCTGCGCCCATGTCCTGGATCCCTACGACGATGCCGGAGTCGATCAGCTCCAGGCACGCCTCGAGTACGAGCTTCTCCATGAACGGATCGCCCACCTGTACCGCCGAACGCTTCGCTTCGGACTCGGCCGTGAGGTCCTCGGATGCGAAGGTCGCCCCGTGAATCCCGTCGCGTCCCGTTGCCGGGCCCACATAGAAGACCGGGTTGCCTACGCCTTTGGCTACGCCCTTCTGGATCTTGTCGTGGTCGATGATGCCGACGCACATGGCGTTAACGAGCGGGTTGCCCTCGTAGCTCTCATCGAACATCACTTCGCCGCCGACCGTCGGAATGCCGATGCAGTTGCCGTAGCCCGCAATCCCGGATACGACGTGCTCGAAGAGGTATTTCACGCGGTCATTCGTCAGACGACCGAAACGCAGGGAGTTCAGCACAGCTACCGGACGGGCACCCATGGAGAAAATGTCCCGTATAATCCCGCCTACGCCCGTTGCCGCCCCTTGGTATGGTTCCACCGCGGAAGGGTGGTTATGGCTTTCAATTTTGAACACAACCGCTTGGTTGTCGCCGATATCCACGATTCCCGCGCCTTCGCCCGGTCCCATCAGGACACGTTCGCCGGTTGTCGGGAACTTGCGCAGTACCGCTTTGGAGTTCTTGTAAGAGCAGTGCTCCGACCACATGACGGAGAATACGCCGATCTCCACATAGTTCGGCTTCCGTCCGAGGAAGCCGCAGATGAGGTCGTACTCGGCATCGGAGACACCGAACTGCTTGTAGATTTTCTGTTCCTGAATCTGTTCTGCCGTTGGTTCCTTAGCCGATAGCTGCTGCGCCATGTTTTTCCCTCCAAGTGCTTAAAATCGATGTAAACATCCGCTTGCCGTCTTCGGAACCGAGCAGCGCCGACACGGCACGTTCCGGATGCGGCATCATGCCGAGGACATTGCCGCCCTTGCTGCAGATGCCTGCGATATCGTCAACCGAGCCGTTCGGGTTGTTGCCCGCTTCGTAACGGAACACGATCTGGTTGTTCGCTTTGAGCTCGGCCAGGGCCGCCTCGTCACAGTAGTAGTTGCCTTCGCCGTGCGCGATCGGGATGTTGATGAGCTCGTCCTGCTTGTACTCCTTGGTGAACGGGGTATCCGTGTTAACTACAGACAGCATCGCCGCATGACAGCGGAACTTCAGCGACTCGTTGCGCAGCATCGCGCCCGGCAGCAGGCCGGACTCGAGCAGAATCTGGAAGCCGTTGCAGATGCCGAGGATGTACTTGCCCTGCTCCGCCGCTTCACGGAGAGCCTTCATGACCGGTGCAAATTGGGCGATTGCGCCGCAGCGCAGGTAGTCTCCGTAGGAGAAGCCGCCCGGTATGATAATACAGTCGTATTTGGAGAGATCCGTCTCGGTATGCCATACATAGTCCACGGGCTGGCCTACTGTGTCTTCCACCGCTTTGTAGCAGTCGATATCACAGTTGGAGCCGGGAAACACCAGAACCGCAAAATTCATGATTGTTGTCCTCCCTAATCCTTGTTAAAAGGTAGCCGGCCGGCTCCTATTCGCTCAGCTCGTAGCGGTAGTCTTCGATGACCGTGTTCGCGAGCAGCTTCTCGCACATGGCTTTGAGGCGCTCTTCCGCAGCAGCGCGGTTGTCCGTGTTCAGTTCCACTTCCAGGTACTTGCCGATCCGCACCTTGTCCACTTCGTCGAAGCCCATGGAGTGCAGCGCGCCCTGCACCGCCGTTCCTTGTACGTCCAGTACGCTTTGCTTAATCGTCACATATACGGTCGCTTTTAACATCGAATAGTACCTCCCAAGGGTATGAAAAATGTCCGTTTGCTCTCTCACCTTACATACTGCGTGTCCATCCTGCATCTGCTCCCCCGGACCGAAGCCCGGGCTGCAGTCATGCGTTTTATCCCAAAACCAAGCGGTTATAAATTTCGCGGTAGCGCCGGCTTGTCTCTTCCACGACTTCTGCAGGAAGCGGAGCAGGCTCGCTGTTCTTGTCCCAGTCCGTGCTGGCCAGATAGCTCCGCACCGGCTCTTTGTCCATGGAGTCGATCTCGGTATCCAGCTCGTACTTGTCCTTCGCCCAGAATCTCGATGAATCCGGAGTGAAGATTTCGTCAATGAGTATGATTTCACCGTCGATCAGGCCGAATTCGAATTTGGTGTCGGCGAGAATAATGCCGCGGTCCTGGCAGAAGGCGTGAGCGTAGTTGTACAGCTGAAGGCTCTTCGCCTGCAGCTGCTCGGTCAGCTCGGCGCCGACAAGCTCTTTCATCCGCTCGATGGAGATATCCTCATCGTGGCCGACATCGTTCTTCGCCGCCGGCGTGAAGATCGGCTGCTCAAAGCGCTGGTTCTTGCGCAGGCCTGCAGGCAGCTTGTGGCCGTTGATCTCGCCCGTCTGCTGGTACTGTCTCCAGCCGCCGCCCGTGATGTAGCCGCGCACCACGCATTCGATGTCGATCCGCTCGGCTTTTTTGGTCACCATGAACCGGTCTTTCATGATCTCCCGGTCCGTGATGATGTCGCCGAGCAGATCCACGTCCGTATGCACCACATGGTTGTCGATGATCTCGGTCGTTTGGTCGAACCAGAACTTGCTCAGCGTGTTAAGCACGTTCCCCTTGTCCGGCACAGCCGGGCTCAGCACCCAGTCGAATGCCGAGATCCGGTCCGATACCGCGATGAGGTAATGGTCTCCAAGCCCGTAAATCTCGCGGACCTTGCCTTTATAGAGCAGCGGCGCCTTGATATACTCCTGCGCGCTGGAAATTGCGATCGTTGACGCTTCCTTCATGGTTTCCCCCGCCTCCCCGTAACCCGGTGCTTCTTAGCTCAAGCCCAGACGTTTGAAAATCGTATCGACATGCTTCAGATGCCAGCTCGGATTGAATGCATCCTCAATCTCTTCCAGGCTGAGGTACTCCCGGATCGCCGGCGTATTCTCCACGATGTCACGGAACGAGCGCTGCTCTTCCCATGCCTGCATGGCCCGCGGCTGCACCGTATCGTAAGCCTGCTCGCGGGAGAGCCCTTTGTCGATCAGCTTCGTCATAACGCGGCCCGAGAACGGAACCCCGTAGGTGCTCTGCATGTTGCGCTTCATGTTCTCCGGGAACACCGTCAGGTTCTTGATGATGTTGCCGAGGCGGTTCAGCATGTAGTTCAGCAGGATCGTCGAATCCGGAAGAATGATCCGCTCGACGGACGAGTGCGAGATATCGCGCTCATGCCACAGGGTGACATTCTCGTAAGCGGAGACCATGTGGCCGCGGATGACGCGGGCCAGACCCGAGATGCTCTCGCAGCCGATCGGGTTGCGCTTGTGCGGCATGGCCGAGGAGCCCTTCTGACCCTTCGCGAACGGCTCTTCCACTTCGCGGAACTCGCTCTTCTGCAGGGCGCGGATTTCCGTCGCGAACTTGTCCAGCGACGTCGCGATGAGCGCCAAAGTCGCCATATACTCGGCGTGGCGGTCACGCTGCAGCGTCTGGGTCGAGATCGGCGCCGGCTTCGTACCGAGCTTGCCGCACACATACTCCTCGATGAACGGATCGATGTTCGCGTAGGTGCCTACGGCGCCCGAGATTTTGCCGAACTGGACACCGTCCGCGGCAAAGCGGAAACGCTCCAGATTCCGCTTCATCTCTTCGTACCAGAGCGCCATCTTGAGACCGAAGGTGGTAGGCTCAGCGTGCACCCCGTGCGTACGGCCCATCATCGGCGTATCCTTGTAAGCCACTGCTTTGTCCTTCAGGATTTCGATGAAGTTCACGATGTCCCGCTCGATGATCTCGTTCGCCTGTCTCAGCAGGTAGCCAAGAGCCGTATCGACTACGTCCGTGGAAGTCAGACCGTAGTGCACCCACTTGCGTTCCGGGCCCACTTTCTCGGATACCGCACGCGTGAAGGCAATCACGTCATGGCGTGTCTCCTGCTCGATCTCGTAGATCCGGTCGATATCGAAGCTTGCGTTCTTCCGCAGCTCCGCTACGTCTTCCTTCGGGATGACACCAAGCTCCGCCCATGCTTCGCAGGAAAGAATTTCGACTTCAAGCCAAGCCTTGAATTTGTTTTCTTCCGTCCAAATGCTGCCCATCTCGGGTCTTGTATAACGATCGATCAT

Protein sequences of DBSCAN-SWA_4

>NC_016935|8085654:8095019|8085654_8086698_-|WP_014372470.1|DBSCAN-SWA
MSDAYKQAGVDIAAGNEAVERMKKHVKTTFRPEVLTELGGFGGLFGLNKDKYEEPVLVSGTDGVGTKLKLAFAMDKHDTIGIDAVAMCVNDIIVQGAEPLFFLDYLACDKVIPEKIEAIVKGISDGCVQAGCALIGGETAEMPGMYSEGEYDIAGFTVGIVDKKKIIDGSTIRPGDVVLGLPSSGIHSNGFSLVRRLLLEQKGYKLDQALEALEGKKLGDVLIEPTRIYVKTILSLLEKVQIKGMAHITGGGFLENIPRVLPKNVNAHIQYGSWPILPIFHLMQQDGSISNNDMFRTFNMGIGMVIVVSAEEAEATLAAARELGESIYRLGEITTGEGIVTFEGAEV
>NC_016935|8085654:8095019|8092435_8092681_-|WP_013920976.1|DBSCAN-SWA
MLKATVYVTIKQSVLDVQGTAVQGALHSMGFDEVDKVRIGKYLEVELNTDNRAAAEERLKAMCEKLLANTVIEDYRYELSE
>NC_016935|8085654:8095019|8089469_8091716_-|WP_013920974.1|DBSCAN-SWA
MAQQLSAKEPTAEQIQEQKIYKQFGVSDAEYDLICGFLGRKPNYVEIGVFSVMWSEHCSYKNSKAVLRKFPTTGERVLMGPGEGAGIVDIGDNQAVVFKIESHNHPSAVEPYQGAATGVGGIIRDIFSMGARPVAVLNSLRFGRLTNDRVKYLFEHVVSGIAGYGNCIGIPTVGGEVMFDESYEGNPLVNAMCVGIIDHDKIQKGVAKGVGNPVFYVGPATGRDGIHGATFASEDLTAESEAKRSAVQVGDPFMEKLVLEACLELIDSGIVVGIQDMGAAGLTCSSSEMASKAGNGMELYLDEVPQREEGMTPYEMMLSESQERMLFVVKPEHEEQAKAIFERWGLHCAKVGKVTDDGNLKLYHKGELVGDMPVTALVDECPMYNKPSSVPAYYEANASVDTTAYPEVTDLNGALKQVLASPTVASKEWVYNQYDYMVRTSTAVQPGSDAAVVTIRGSRKALSMSTDCNGRYVYLDPEVGGKIAVAEAARNNVCSGAEPLAITDNLNFGSPEKPEIFWQLEKSVDGMAEACRKLNTPVIGGNVSLYNENARGAIYPTPVVGMVGLVHDTDHITTQGFKNEGDIVLLLGETKAELGGSEFQYVVHGVTEGRPPQIDLDVEKTLLDTVLGAIQKGLVASAHDLSDGGLAVALAESCISGRLGANVNLTTDLRADIALFSESQSRLLLSAAPEKASELEAVLKAAGVPVQVIGKVEGTSLQVQVNGSAAIDAAVAELQQVWKDAIPCLMNA
>NC_016935|8085654:8095019|8087904_8089413_-|WP_051045049.1|DBSCAN-SWA
MRQGGNGQGQHDGAFPLWTGAYYNEGMGAGPNGLSDKLGEECGVFGVFGHPEAANLSYYGLHALQHRGQESSGICVAGEDAFNYHRGMGLVKEVFNNDNLGPMVGSYAIGHVRYSTAGESKLANAQPLVFKYREGDLAIATNGNLTNAPDIKKRLEREGSIFQTTSDTEVVAHLIARSKHDDIVEAVRDALLQIEGAYAFLFLTRDKLIAARDPHGLRPFVMGRLGDAYLFASESCAFDTVGGLYERDIQPGELLILNQRTGELTHDRFAEGKQRAVCAMEYIYFARPDSDIDEVNIHSARKRMGRQLAIESFVDADIVTGVPDSSISAAIGYAEQTGIPYELGLIKNRYTGRTFIQPSQELREQGVKMKLSAVRSIVHGKRVVMIDDSIVRGTTSLRIVNMLREAGATEVHVRISSPPFQNPCFYGIDTPNRGELIAAVKSVEEIRKAINADSLHFLSQEGLVNSIGGPAGEINRGHCTACFDNRYPTAIPDDAKIGCGCD
>NC_016935|8085654:8095019|8093723_8095019_-|WP_013920978.1|DBSCAN-SWA
MIDRYTRPEMGSIWTEENKFKAWLEVEILSCEAWAELGVIPKEDVAELRKNASFDIDRIYEIEQETRHDVIAFTRAVSEKVGPERKWVHYGLTSTDVVDTALGYLLRQANEIIERDIVNFIEILKDKAVAYKDTPMMGRTHGVHAEPTTFGLKMALWYEEMKRNLERFRFAADGVQFGKISGAVGTYANIDPFIEEYVCGKLGTKPAPISTQTLQRDRHAEYMATLALIATSLDKFATEIRALQKSEFREVEEPFAKGQKGSSAMPHKRNPIGCESISGLARVIRGHMVSAYENVTLWHERDISHSSVERIILPDSTILLNYMLNRLGNIIKNLTVFPENMKRNMQSTYGVPFSGRVMTKLIDKGLSREQAYDTVQPRAMQAWEEQRSFRDIVENTPAIREYLSLEEIEDAFNPSWHLKHVDTIFKRLGLS
>NC_016935|8085654:8095019|8092796_8093690_-|WP_013920977.1|DBSCAN-SWA
MKEASTIAISSAQEYIKAPLLYKGKVREIYGLGDHYLIAVSDRISAFDWVLSPAVPDKGNVLNTLSKFWFDQTTEIIDNHVVHTDVDLLGDIITDREIMKDRFMVTKKAERIDIECVVRGYITGGGWRQYQQTGEINGHKLPAGLRKNQRFEQPIFTPAAKNDVGHDEDISIERMKELVGAELTEQLQAKSLQLYNYAHAFCQDRGIILADTKFEFGLIDGEIILIDEIFTPDSSRFWAKDKYELDTEIDSMDKEPVRSYLASTDWDKNSEPAPLPAEVVEETSRRYREIYNRLVLG
>NC_016935|8085654:8095019|8091693_8092389_-|WP_013920975.1|DBSCAN-SWA
MNFAVLVFPGSNCDIDCYKAVEDTVGQPVDYVWHTETDLSKYDCIIIPGGFSYGDYLRCGAIAQFAPVMKALREAAEQGKYILGICNGFQILLESGLLPGAMLRNESLKFRCHAAMLSVVNTDTPFTKEYKQDELINIPIAHGEGNYYCDEAALAELKANNQIVFRYEAGNNPNGSVDDIAGICSKGGNVLGMMPHPERAVSALLGSEDGKRMFTSILSTWREKHGAAAIG

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014372470.1|8085654_8086698_-	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	1.3e-72	46.8
WP_051045049.1|8087904_8089413_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	2.3e-51	32.6
WP_013920974.1|8089469_8091716_-	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	5.6e-166	42.5
WP_013920975.1|8091693_8092389_-	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_013920976.1|8092435_8092681_-	phosphoribosylformylglycinamidine synthase subunit PurS	A0A0E3FJ99	Synechococcus_phage	1.5e-08	39.2
WP_013920977.1|8092796_8093690_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A0M4JBD3	Mollivirus	4.5e-42	32.8
WP_013920978.1|8093723_8095019_-	adenylosuccinate lyase	A0A2H4UUU6	Bodo_saltans_virus	3.1e-20	25.4