CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_018681	Nocardia brasiliensis ATCC 700358, complete sequence	12 crisprs	WYL,csa3,DinG,DEDDh,casR,cas6e,cas5,cas7,cse2gr11,cas8e,cas4,cas3	0	2	0	0

Cas Category Instructions

Results visualization

1. NC_018681

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CRISPR-Cas detection and classification

Crispr_ID: NC_018681_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_018681_1

317582-317759

Orphan

Consensus_repeat	Method
GCGCAGTCCGGTCCAACCACGCAGGGCGCGCCAGTCGCACAGGGTG	PILER-CR

2 spacers

The CRISPR arrays of NC_018681_1

>merge|NC_018681|1|317582-317759|PILER-CR
CAGGCCGCGCCGACCACGCAGGGCGCGCCCGACGCGCAGCCGACATCAGCCCCGCAGGGTGCGCCGACTGCGCAGTCGGGTCCCACCACGCAGGGCGCGCCAGTCGCACGGGGTGCATCCGCCGCACAGGGCGCGCAGTCTGGTCCAACGACGCAGGGCGCGCCAGTCGCACAGGGTG

>NC_018681|1|1|317582-317759|PILER-CR
CAGGCCGCGCCGACCACGCAGGGCGCGCCCGACGCGCAGCCGACAT	CAGCCCCGCAGGGTGCGCCGACTGCGCAGT
CGGGTCCCACCACGCAGGGCGCGCCAGTCGCACGGGGTGCATCCGC	CGCACAGGGCGCGCAGT
CTGGTCCAACGACGCAGGGCGCGCCAGTCGCACAGGGTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_018681.1\|WP_014981099.1\|310703_312980_-\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NC_018681.1\|WP_041562344.1\|309217_309925_-\|hypothetical-protein	unknown	unknown	unknown
NC_018681.1\|WP_014981110.1\|331193_331544_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|380093
NC_018681.1\|WP_014981093.1\|304285_304618_+\|hypothetical-protein	unknown	unknown	unknown
NC_018681.1\|WP_041563281.1\|320339_322475_+\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|236864
NC_018681.1\|WP_014981103.1\|319063_320278_+\|acetyl-CoA-C-acetyltransferase	unknown	unknown	gnl\|CDD\|236197
NC_018681.1\|WP_014981096.1\|307552_308842_-\|ROK-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224851
NC_018681.1\|WP_014981094.1\|304625_305543_-\|neutral-zinc-metallopeptidase	unknown	unknown	gnl\|CDD\|225203
NC_018681.1\|WP_014981109.1\|330707_331142_+\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|378454
NC_018681.1\|WP_014981098.1\|310029_310707_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_018681.1\|WP_014981095.1\|305874_307494_+\|DUF2207-domain-containing-protein	unknown	unknown	gnl\|CDD\|378333
NC_018681.1\|WP_014981106.1\|324143_327701_+\|protein-kinase	unknown	unknown	gnl\|CDD\|225461
NC_018681.1\|WP_014981108.1\|329057_330500_-\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223354
NC_018681.1\|WP_014981112.1\|332432_333014_-\|hypothetical-protein	unknown	unknown	unknown
NC_018681.1\|WP_014981111.1\|331559_332375_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133382
NC_018681.1\|WP_014981101.1\|314524_315349_-\|hypothetical-protein	unknown	unknown	unknown
NC_018681.1\|WP_014981100.1\|313066_314371_-\|ammonium-transporter	unknown	unknown	gnl\|CDD\|223083
NC_018681.1\|WP_014981092.1\|303612_304185_+\|(Fe-S)-cluster-assembly-protein	unknown	unknown	gnl\|CDD\|132296
NC_018681.1\|WP_041563282.1\|322657_323779_+\|esterase-like-activity-of-phytase-family-protein	unknown	unknown	gnl\|CDD\|379191
NC_018681.1\|WP_014981107.1\|327744_329061_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|367049

Protein	Function_ID	Function_description	E-value
NC_018681.1\|WP_014981099.1\|310703_312980_-\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	5.29981e-89
NC_018681.1\|WP_014981110.1\|331193_331544_-\|VOC-family-protein	gnl\|CDD\|380093	pfam18029, Glyoxalase_6, Glyoxalase-like domain. This entry comprises a diverse set of domains related to the Glyoxalase domain. The exact specificity of these proteins is uncertain.	2.56071e-29
NC_018681.1\|WP_014981103.1\|319063_320278_+\|acetyl-CoA-C-acetyltransferase	gnl\|CDD\|236197	PRK08242, PRK08242, acetyl-CoA C-acetyltransferase.	0
NC_018681.1\|WP_041563281.1\|320339_322475_+\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|236864	PRK11154, fadJ, fatty acid oxidation complex subunit alpha FadJ.	3.2718e-141
NC_018681.1\|WP_014981111.1\|331559_332375_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133382	cd01107, HTH_BmrR, Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator. Helix-turn-helix (HTH) multidrug-efflux transporter transcription regulator, BmrR and YdfL of Bacillus subtilis, and related proteins; N-terminal domain. Bmr is a membrane protein which causes the efflux of a variety of toxic substances and antibiotics. BmrR is comprised of two distinct domains that harbor a regulatory (effector-binding) site and an active (DNA-binding) site. The conserved N-terminal domain contains a winged HTH motif that mediates DNA binding, while the C-terminal domain binds coactivating, toxic compounds. BmrR shares the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements.	3.02123e-41
NC_018681.1\|WP_014981095.1\|305874_307494_+\|DUF2207-domain-containing-protein	gnl\|CDD\|378333	pfam09972, DUF2207, Predicted membrane protein (DUF2207). This domain, found in various hypothetical bacterial proteins, has no known function.	4.57855e-31
NC_018681.1\|WP_014981094.1\|304625_305543_-\|neutral-zinc-metallopeptidase	gnl\|CDD\|225203	COG2321, COG2321, Predicted metalloprotease [General function prediction only].	1.00322e-27
NC_018681.1\|WP_014981109.1\|330707_331142_+\|SRPBCC-family-protein	gnl\|CDD\|378454	pfam10604, Polyketide_cyc2, Polyketide cyclase / dehydrase and lipid transport. This family contains polyketide cylcases/dehydrases which are enzymes involved in polyketide synthesis. It also includes other proteins of the START superfamily.	5.31378e-07
NC_018681.1\|WP_014981098.1\|310029_310707_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.95299e-13
NC_018681.1\|WP_014981096.1\|307552_308842_-\|ROK-family-transcriptional-regulator	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	2.55289e-31
NC_018681.1\|WP_014981106.1\|324143_327701_+\|protein-kinase	gnl\|CDD\|225461	COG2909, MalT, ATP-dependent transcriptional regulator [Transcription].	8.67603e-124
NC_018681.1\|WP_014981108.1\|329057_330500_-\|FAD-binding-oxidoreductase	gnl\|CDD\|223354	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion].	4.87917e-34
NC_018681.1\|WP_014981100.1\|313066_314371_-\|ammonium-transporter	gnl\|CDD\|223083	COG0004, AmtB, Ammonia permease [Inorganic ion transport and metabolism].	5.02175e-161
NC_018681.1\|WP_014981092.1\|303612_304185_+\|(Fe-S)-cluster-assembly-protein	gnl\|CDD\|132296	TIGR03252, TIGR03252, uncharacterized HhH-GPD family protein. This model describes a small, well-conserved bacterial protein family. Its sequence largely consists of a domain, HhH-GPD, found in a variety of related base excision DNA repair enzymes (see pfam00730). [DNA metabolism, DNA replication, recombination, and repair].	3.92764e-96
NC_018681.1\|WP_041563282.1\|322657_323779_+\|esterase-like-activity-of-phytase-family-protein	gnl\|CDD\|379191	pfam13449, Phytase-like, Esterase-like activity of phytase. This is a repeated domain that carries several highly conserved Glu and Asp residues indicating the likelihood that the domain incorporates the enzymic activity of the PLC-like phospho-diesterase part of the proteins.	1.4603e-81
NC_018681.1\|WP_014981107.1\|327744_329061_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|367049	pfam02353, CMAS, Mycolic acid cyclopropane synthetase. This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.	7.72057e-121

>NC_018681.1|WP_014981101.1|314524_315349_-|hypothetical-protein
MSPDDIAAALLASTDFAGNRSAVDLLSRAISPQDFAIKRDSLPVTAAADPATSTAILELLERGQVPTMAAIRTLTAQNEMRREAERIERLGRRAQRSIDDFGRALAVLADAHWTAHGIGPTRRDVLSSDEVMSLIRTRIGDIAPSAVKHLWLIERAQRAGWIASNANAGSLCAGRRFHADQYGNRVSLRPVNTIGTAVAAYLADYRTEHGRAPRWCTVAQELRDDRGRRVFHNTADARAQELWLTTADWVALEDELPVPGKRGQRAIARKSRTS
>NC_018681.1|WP_014981100.1|313066_314371_-|ammonium-transporter
MPTPLDPAATAWLLVSTALVLLMTPALALFYGGMVRSTGVLNMLMMNFIAIPLVTVAWLLLGYSMAFSDDAGGGLIGNLDHFGMANIDPGTVRGAVPELLFATFQLTFAILTAALVSGAIADRAKFAAWMVFVPVWALAVYAPIAHWVWGPDGWLASFGALDYAGGLVVEIASGASALALALVLGPRIGFKTDAMRPHNLPFVLLGAGLLWFGWFGFNAGSALSANGIAAAVFLNTLVAGCLGMLGWLAVEQIRDGRPTTFGAASGVVAGLVAITPSCGSVNTLGALVVGLAAGVVCSFAVGWKFKAGYDDSLDVVGVHFVGGIVGTVLIGLLATQVMTGGVDGLFFGGGFAQLGKQLVGVLVVAAYAFLVTFALGKLIDRVIGFRVSKEDETAGIDFALHAETAYAEGVHGHAPRRFGEGGHFGHSTASDRDH
>NC_018681.1|WP_014981099.1|310703_312980_-|MMPL-family-transporter
MLIRIAQLVTRYPRAILIAAAALAIACGAFGATAASHLKSAGFTSPDADSSEVTRLLADNFDGAAPNYILLVSSDAGADAPATRAVGTRLVETLRARPDVKGVQSYWTAPPAVGSALRSTSGKDALVLAYLTGDDTEAQRTAGELTEQLAGSADGVTVRQSGIASVFHDVNKQITHDLAVAEAVAIPISLIVLILVFGSVIAAALPLTVGIFAILATLAILRMFTLITDVSIYALNMTTAMGLALAIDYSLFIVSRYREELANGLDPVRATIRAVQTAGRTVLYSALTVALSMSVLSIFDIYFLRSFAYAGVAVVVAAAAAAIVILPAALVLLGHRVNALDIRIPLRRMFGRPTPDPLRSQRPEQSWWYRVVTWVTRRSVPVALLLVALFLALGSPFLSVKFGYPDDRVLPTSAASRQVGDVLRAEFPAANSGNNTTIVLDGYQGGPGPIGAYATGLSRVDGVSAVLSSAGIYIKGARVASGPPGMANGTGEYVSVATRPDPFSPAGKAQLLALRDVPAPGPTLFGGAAAVNADALDSLSKRMVPAVALIALATFVVLFLFTGSVLLPLKAIVLNTLSMAAAFGAMVWIFQDGHLSDLLGFTAVGYLTPTTPILMFCVAFGMSMDYEVFLLSRIREEWLASGRVVDGVVVRTAEDNVHALAVGIARTGRIYTAAALLMAIVIGAMITSKVSFIQLMGLGLTLTVLADATLIRTMLAPALMKLMGTANWWAPKPLARLHARIGLREESDPAEPVLAGHK
>NC_018681.1|WP_014981098.1|310029_310707_-|TetR/AcrR-family-transcriptional-regulator
MIRAGRSRSARGAGAQLRTEILDAATELLTRTGHADAVSIRAISQRVGVSAPSIYRHFADKDELIGAVVVQVFENLDAAIVAATDPADTPLTRMQQQGLAYVRFAREHPEQYRLATLPTESSSAVDQVMTSGAFQHFSQTVQDCMDAGVFTPGDTLPVVLDLWAAAHGIASLLIAKPFIPWGDTEEVANRVLRAACVGHVVVDLIGPDPAPADLMDWLAGQRRSR
>NC_018681.1|WP_041562344.1|309217_309925_-|hypothetical-protein
MRMRKLAVVAALVTTATGVAAGTSVAAPENTPGPVHFTARTTDTSSIIETDAGSLVVEDGAFKVKAADGTTVAATPLTLRIDEFEFPIAAQISQRTATLTPQLDQAHATYKPVALPFEDKAPWKSEYDREQAAWSRLTSTISAGATIGTLVGGLGGAAVGCVLGGIAGATVASATIIGLFGPFIPAAAIGCLGGIIAIGALGTVAGQIFVTAPVAIGAAIQYFTTINQPFVAPPK
>NC_018681.1|WP_014981096.1|307552_308842_-|ROK-family-transcriptional-regulator
MSLPTLERSTARVTNGRARVQRPVVAPELRLGDNPAAAVLRAATGGPVSRDNAARTTGLSIATVNRQVSALLAAGLLRERPDLTASGAVGRPRVPFEIDHEAYLTLGIHVGAAVTKIVAADLRGRILGGLAIATPQTGQEFATTTVARSAKAFLQRWHRRKPLWAGVAIGGRVDPVTGVVDHPKLEWQGAQIGAVLGEVLELPVSVAPHVEAMAASELLLPTIESRDAAAGRTAGPERGSSLYFYVRETAGVAVTLDGRVHTPSNGPGSIAHLPTGSDVECTCGRRGCLEVTVGDRSLHSRAVGRGIIPAHNGTAGSTIADLYRAAEAGSEPARELLAERATILGNTVAMVRDMLNPDRVILGGQAFTGYRPAVAHVARAFNQGSSLPPTDIRISGFGGKVQEFAAVVTSLSVLYADPLAAIRRTTLAD
>NC_018681.1|WP_014981095.1|305874_307494_+|DUF2207-domain-containing-protein
MLTFRGAAVGALLLASAALFATAPAAHPEPAPSGVTITADLKLNRDGVLEVVEQVEVPPDGTFQMSLPLRLQVRDDVERRFKVTDVDTKGAGTATVANDQFTIEAKPGTSTFTYSVHNLVSDAPGSQVFNWLGVVRSDIAAISATLISPSFEMGIVDCKLGPPGNTRACADVKTEVDGVLYLEQTDLHKGDAIDLTLQLPPNTVPSNADVRDDSAAGPFAFTTPVLVAFGVLVLALIGLAVFVLRARRQNAAAGTGSQTLDPLLREGERVQFVSPDGVLPGEAGLLLDEHVDPVDIAATVVDLAVRRYIRVLPLSDADWRITRVNTPDDQLRGYERAVYLALLPDGTDAVTMTELRAPGRVQSGPVRTALLDDAVARGTFTDRRRPGLAGWLGGALIVAGIAATIGLALTAGHALVGVAIALAGIATALLPKYLPVRTAHGLALSGQIRALQRGLETTRREQVPPIDQETVFSRALPFMVIGSRADNWIRAFRDLNPSADAQPGLYWFGGFERDRNLQRFAGHFPFFITALEGLFAPER
>NC_018681.1|WP_014981094.1|304625_305543_-|neutral-zinc-metallopeptidase
MPYGPPGRPPYPPRRRSGGGGAWIALLVVVVFLVVGGLVRNAISVGRNDSSPSTVTPSLTFSPDGSTGPAETGANPLLADPSATLIPARCPYSPWGTQVDAARKFFESAASCLEAAWKPVLQKANLPFQPPTLNVSATTTGITTPCTGTTSNFAAFYCPANKTIYMPVSQLQTDFFKDNWVVYLSVFAHEYGHHIQAMSGILRKANSERADAGPRSTRGLELSRRVELQANCFDGMYIASSSGGGSLTNSQLNVARKDAYGRGDQAGDMRDHGTAENGGQWFETGLDKNRAAQCNTFTAPASSVN
>NC_018681.1|WP_014981093.1|304285_304618_+|hypothetical-protein
MRRRPAAIGYLRRDVSGARQQWDEVLIRSLAQRFGYDLAKTVVFGAETDDVLHRLTTVAQRLGVDAVIVPAAAHFEGGIPEQLVQLCDVITVAPEYTYARPLQPPLADGA
>NC_018681.1|WP_014981092.1|303612_304185_+|(Fe-S)-cluster-assembly-protein
MSRKLCLAQDVEADELLTEDHFATLLGMLLDQQYPMEHAFRGPKKIADRMGGFDIHRIAEADQQEFEDLCATPPAIHRYGRSMARRAQDLARYIIENYDGRTENLWKKDKPDGKEVLRRLKDLPGFGEQKAKIFLSLLGKQRGVQPAGWREAAGAYGDEGSRRSVADVTDAETLAQVREFKKQAKAAAKK
>NC_018681.1|WP_014981103.1|319063_320278_+|acetyl-CoA-C-acetyltransferase
MTTEAYIYEAIRTPRGRGKKNGSLHSVKPIDLTVGLIQELRGRFPNLDEDRISDLILGVVSPVGDQGMDIARTAVTVAGLPDTVGGFQLNRFCASGLEAVNLAAQKVRSGFDDLVIAGGVESMSRVAMGSDGGAWALDPATNYDTYFVPQGVSADLIATIEGFSREDVDAYAVRSQELAAKATTGGYFAKSIVPVKDQNGIVVLDKDEHMRPGTTSEDLAKLNPSFAVIGEMGGFDAVALQKFYFVEKINHVHHGGNSSGIVDGAALVLVGTEDAGKASGLTPRARVVATATSGADSTIMLTGPTPAAKKALAKAGLTIEDMDLVEINEAFASVVLKFQKDLNVPDEKLNVNGGAIAMGHPLGATGAMITGTMVDELERRNGRYALITLCIGGGMGVATIIERV
>NC_018681.1|WP_041563281.1|320339_322475_+|enoyl-CoA-hydratase/isomerase-family-protein
MIGWEQDSDGIVVLTMDDPNQGANTMNELYKSSMTATVEKLEAEKDSITGVVITSAKKTFFAGGDLKNMMKVGPEDGQGVMDELGTIKGALRRLETLGKPVVAAINGAALGGGLEIALACHYRIAADVPGSQIGLPEVTLGLLPAGGGVIRTVRMLGLQNALMQVLLQGQRNKPAKAKEIGLVNELVGTVEELVPAAKAWIKANPDKGVQPWDVKGFKIPGGTPSSPAFAANLPAFPANLRKQIKGANMPAPRAIMSAAVEGSQVDIDNASLIESRYFVHLLTGPVAKNMIQAFFFDLQSINNGGSRPKDVPKKDIKKIGVLGAGMMGAGIAYVSAKAGYQVVLKDVSIEAAERGKNYSEKIEAKALSRGKTTEEKSKALLDRITPSADAKDFDGVDFVIEAVFENTELKHKVFQEIEDIVTPDALLGSNTSTLPITGLAKGVKREEDFIGIHFFSPVDKMPLVEIIKGEKTSPEALARVFDYTLAIKKTPIVVNDSRGFFTSRVIGTFVNEAIAMLTEGIEPATIEQAGLQAGYPAAPLQLSDELNMKLMQKIAKETIEAAEHGDTTMGKKRHPAQDVIDYMVGESRPGRLEKAGFYEYDENGKRTGLWPGLREHFKTTADFTVPLQDLIDRMLFAEAIETQKCFDEGVLETTADANIGSIFGIGFPAWTGGVHQFIVGYPGGQAAFVERADYLAKTYGERFEVPASLRK
>NC_018681.1|WP_041563282.1|322657_323779_+|esterase-like-activity-of-phytase-family-protein
MGRRVVRGQTLVIAALAVALGAVPAARAVPEAAAGPGAGAVRLLGAQVVPNDLVYQGTAVGGLSGIDFDSRTGDYVLISDDRSERNPARFYTARFAVGPDGLGPVSFTGTRPLPTANGAPYGPKSVDPEEIRVDPWTGNYFWTQEGERTATVLADPSVRVSRPDGSFAGELPIPDNERMQPNSGPRQNSVLEGATFAAGGALFVTSVEAPLLQDGPEPTTTAGAPARLTVQARTGALLAQYVYPLEPVFAESRPTPGQGGNGIASILAADPYDPSKILVLERAFVVGVGNKIRIYEADLGGASNVLDAPIGNARPVTKRLLVDLADVGLPAIDNVEGVTWGPRLPSGERTLVLVSDNNFAPNQITQLIALAVR
>NC_018681.1|WP_014981106.1|324143_327701_+|protein-kinase
MNPRTRSEEVGPDSTPADSDTQRHPLLGIADELEAMGLSDAKEIGRGGFGVVYRCVQRTLERVVAVKVLSSEIEVESRERFLREEQAMGRLSGHPNIVDILQVDVTPSGLPFIVMPYCTRGSLEQVIRDQGPLTWADSLRAGVKLAGAIESSHRAQILHRDVKPANVLLSGYGEPQLTDFGIARIPGGFQTSSSMITGSPAFTAPEVLKGDDPTIRSDVYGLGATLFALLTGHAAFERQAGEKVVAQFLRITTQPVPDLREHDIPADVAEVIQHAMATDPADRPTTAYDFGQLLRSVQRDHDHMPDEMALLETVAAPEPIDRPAETSSSRPAVTARRSWPLTLRPAVSQHTGGGRQTGTGATLPPTAATKFRPPTPAREPVPRPRLLDVLRAGGRRRLAVIHAPAGFGKSTVAAQWRTDLTERGIPVAWLGVDHGDDNEIWFLAHLIQAIRRVRPDIGNGLDQVLEERPADAAAFVISTLIDEIHASGSTLVVVVDDWHRVTDAGAHRAMDALLDNGCHHLRFVVTSREQSGLPTSRMRVHDELVEIGSAALRLTAAETREILVQRHGFALTDSQVSEIHRTTDGWPAAIQLVSLSLRGKTDPAQLLAQLSGGNHGIREYLAENVLDTLEPRMLDFLMSIAVTERVCGSLASALSEDEDAEQLLIQAEQRELFLRRIEHDPEWFRMQPLFAEHLRARLERAQPGKSKTLHRKASRWYAEHQLLRKSVDHALAATDLKMALDLLEVGGMDLIDRSRLATLLGTVSKLPMQQVASRSKLLMAVARANVNLQQSGAARTALGRLSNLLARGAATDEDVKQQRCQAAVLGAADQIARDRTEGVLDRVADCLQSPQDLPAWTVSTAANLTSFVRLCEFDFDGARSIQDWAAEYHARSKDPLGAVFGLCGRGAAAYEQLDIPTATQCFQEAWEVAKARSGPRSHAVRVAAALLGELNYRRGDLDVADQLLDESHQLVARVGPVDFLIATFVVGARVKAVLGDLFTAAARLDEGARIAADNRLTRLGAHIRAERVRLGLALERDGQSAEAPAGALHPRHRMIGAAVLAAEAEEIAAIRTLLAEGSLGSDDRAVRRSRALYARMVDKHRPRAELDAALLLAECLAASGWVGEATGLLLPAAATCAELGWTRPLLDAGPGVVSILRVLRAEMPSAAAHTGDIELPALFLDELLD
>NC_018681.1|WP_014981107.1|327744_329061_-|class-I-SAM-dependent-methyltransferase
MTTFKDRSDVLADLGTKLSIAEIFETLIEGEVPIRLTAYDGSTTGPADSKYQLDIKTPRGINYLATAPGDLGMARAYIAGDMTAEGVHPGDPYDILKAMDSLKFRRPSALALLAIARSLGWERLKPIAPPPQETLPRWRRIALEGLRHSKTRDAEAIHHHYDVSNTFYEYVLGPSMTYTCACYENEEQTLEQAQENKYRLVFDKLRLKEGDRLLDIGCGWGGMVRYAAKRGVKVIGATLSAEQAEWAQAKIAEQGLSELAEVRHSDYRDIPESGFDAVSSIGLTEHIGVHNYPYYFEFIQSKLRDGGLFLNHCITRPDNTRTTKAGDFIDRYVFPDGELIGSGRIISEIQNVGLEVLHEENLREHYALTLHEWCKNLVQNWDACVDEVGEGTAKVWGLYMAGCRLGFQRNVVQLHQVLGVKLPPDGTWTVPLRPWWTA
>NC_018681.1|WP_014981108.1|329057_330500_-|FAD-binding-oxidoreductase
MSLLGKAGRAPVARESGFTAHHAGVERLLASYRAIPRNANVRLAKKTSNLFRARAKNPAPGLDVSGLTGVIAVDPVAKTADVAGMTTYEDLVAATLPYGLAPFVVPQLKTITLGGAVTGLGIESTSFRNGLPHESVLEMDILTGAGEIITATPDNEHADLFRGFPNSYGTLGYSVRLKIELETVQPFVAIRHLRFHDLRELERTLADIVIERSYDGERVDYLDGVVFTADESYLTLGRQTDEPGPVSDYTDMDIYYRSIQHDDAAPKRDRLTIHDYLWRWDTDWFWCSRAFGTQNPKIRRFWPKRYRRSSFYWKLIALDHKYDIADKLEARKGNPPRERVVQDIEVPVERTADFVEWFLREIPIEPLWLCPLRLRDTGDTSGSTERTWPLYPLEPNRTYVNAGFWSAVPTVPGAPEGAANRAIERTVTDFDGHKSLYSDSYYDKDEFAALYGGNTYTELKKRYDPDQRLLDLYSKAVQRK
>NC_018681.1|WP_014981109.1|330707_331142_+|SRPBCC-family-protein
MGQVSASSSIAVAADPQRTLEAIADYETVRPRILSAHYRDYKVVEGGKGAGTVAEWTLQATEKRSRNVHAVVTVSDSIVTERDSNSTLVTTWTVTPDGTGSQVTQRTIWQGAGGVKGIFEGIFAPLGLKKIQAEVLGNLQKELA
>NC_018681.1|WP_014981110.1|331193_331544_-|VOC-family-protein
MTLALAHITIDSADAAALADFWSELLDLPVDPEASTEFATVGRTAAAAPVLMFIRVPDKTPGKNVIHLDLHAADWRRHVDRAIGLGAKRIGDFDEYGAQWTTLADPEGNLFDIGAQ
>NC_018681.1|WP_014981111.1|331559_332375_-|MerR-family-transcriptional-regulator
MTATVAIGEFARLTYLTVKTLRYYHDIELLAPVSIDSGSGYRRYSIDQVPQAHLIRRLRQLDMPLPEIKAVLDAADEDTRNAALRAHLERMEAELARTRAVVTSLRALLTPTAPLAVEYRSEPAFPALAIAEVVTREAIGPWCEAAFTLLHQTLGAAGIAPNGVDGATYSMEFFENDIGAVVAFVPIPGDAEIALPDRVSRIELPARRFAVARHDGPFDDFDRTYGALGSHVAEHDESLAEPIRERYLVSPDATDDPHAYRTEVCWPIGLL
>NC_018681.1|WP_014981112.1|332432_333014_-|hypothetical-protein
MHAIRARFLSTLVLSLGIPGILLGVGGPVATADPGVTEAAADYGGGCVLYPDNRAATIDALRFRCGPEQQDAIFRDAPRGAVPTGVKDGWVTRPPSIQGISSAFWIGKVFYTGPDGGTLTNRVTGAGYEAWPAYVYTAPALLDGNPAWALDYAPAPTPQVYDEIREVTPGVWFGYSWWRGGVQTTMLLTFVLT

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Click the colored protein region to show detailed information

Crispr_ID: NC_018681_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_018681_2

516693-516795

Orphan

Consensus_repeat	Method
CCTCCCCGACAGCACCACAACGGAGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_018681_2

>merge|NC_018681|2|516693-516795|CRISPRCasFinder
CCTCCCCGACAGCACCACAACGGAGCAAGCCTGCGGGCAAGGCTGCCGCGTGAACGTCGGACTCAGGCGTAACTGTGCCTCTCCGACAGCACCACAACGGAGC

>NC_018681|2|1|516693-516795|CRISPRCasFinder
CCTCCCCGACAGCACCACAACGGAGC	AAGCCTGCGGGCAAGGCTGCCGCGTGAACGTCGGACTCAGGCGTAACTGTG
CCTCTCCGACAGCACCACAACGGAGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_018681.1\|WP_171904449.1\|512470_513076_+\|GTP-cyclohydrolase-I-FolE	unknown	unknown	gnl\|CDD\|236472
NC_018681.1\|WP_051066879.1\|513197_514040_+\|dihydropteroate-synthase	unknown	unknown	gnl\|CDD\|238380
NC_018681.1\|WP_014981268.1\|509842_512248_+\|ATP-dependent-zinc-metalloprotease-FtsH	unknown	unknown	gnl\|CDD\|273520
NC_018681.1\|WP_081593879.1\|516992_517994_+\|DUF2520-domain-containing-protein	unknown	unknown	gnl\|CDD\|227782
NC_018681.1\|WP_014981278.1\|519389_520187_+\|type-III-pantothenate-kinase	unknown	unknown	gnl\|CDD\|237347
NC_018681.1\|WP_042254905.1\|523906_524554_+\|FHA-domain-containing-protein	unknown	unknown	gnl\|CDD\|366133
NC_018681.1\|WP_014981277.1\|518948_519371_+\|aspartate-1-decarboxylase	unknown	unknown	gnl\|CDD\|376751
NC_018681.1\|WP_014981282.1\|523338_523698_+\|Lsr2-family-protein	unknown	unknown	gnl\|CDD\|378714
NC_018681.1\|WP_051066471.1\|508536_509484_-\|hypothetical-protein	unknown	unknown	unknown
NC_018681.1\|WP_014981273.1\|515009_515486_+\|DUF3180-domain-containing-protein	unknown	unknown	gnl\|CDD\|378650
NC_018681.1\|WP_029900679.1\|521002_521425_+\|sulfurtransferase	unknown	unknown	gnl\|CDD\|238724
NC_018681.1\|WP_041562361.1\|507615_508452_+\|DUF1266-domain-containing-protein	unknown	unknown	gnl\|CDD\|377728
NC_018681.1\|WP_014981265.1\|507226_507487_-\|DUF2277-domain-containing-protein	unknown	unknown	gnl\|CDD\|378364
NC_018681.1\|WP_014981284.1\|524682_525279_+\|DUF1772-domain-containing-protein	unknown	unknown	gnl\|CDD\|227787
NC_018681.1\|WP_014981272.1\|514470_515013_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	unknown	unknown	gnl\|CDD\|223872
NC_018681.1\|WP_014981276.1\|517993_518923_+\|pantoate--beta-alanine-ligase	unknown	unknown	gnl\|CDD\|234741
NC_018681.1\|WP_014981281.1\|521723_523223_+\|lysine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234778
NC_018681.1\|WP_081593878.1\|515556_516600_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|374080
NC_018681.1\|WP_014981271.1\|514036_514474_+\|dihydroneopterin-aldolase	unknown	unknown	gnl\|CDD\|376737
NC_018681.1\|WP_041562362.1\|520370_520994_+\|cysteine-dioxygenase-family-protein	unknown	unknown	gnl\|CDD\|380416

Protein	Function_ID	Function_description	E-value
NC_018681.1\|WP_171904449.1\|512470_513076_+\|GTP-cyclohydrolase-I-FolE	gnl\|CDD\|236472	PRK09347, folE, GTP cyclohydrolase I; Provisional.	1.27623e-114
NC_018681.1\|WP_051066879.1\|513197_514040_+\|dihydropteroate-synthase	gnl\|CDD\|238380	cd00739, DHPS, DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and protein biosynthesis. Prokaryotes (and some lower eukaryotes) must synthesize folate de novo, while higher eukaryotes are able to utilize dietary folate and therefore lack DHPS. Sulfonamide drugs, which are substrate analogs of pABA, target DHPS.	2.62466e-106
NC_018681.1\|WP_014981268.1\|509842_512248_+\|ATP-dependent-zinc-metalloprotease-FtsH	gnl\|CDD\|273520	TIGR01241, ATP-dependent_zinc_metalloprotease_FtsH, ATP-dependent metalloprotease FtsH. HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides].	0
NC_018681.1\|WP_081593879.1\|516992_517994_+\|DUF2520-domain-containing-protein	gnl\|CDD\|227782	COG5495, COG5495, Uncharacterized conserved protein [Function unknown].	4.18064e-75
NC_018681.1\|WP_014981278.1\|519389_520187_+\|type-III-pantothenate-kinase	gnl\|CDD\|237347	PRK13318, PRK13318, type III pantothenate kinase.	1.71648e-126
NC_018681.1\|WP_042254905.1\|523906_524554_+\|FHA-domain-containing-protein	gnl\|CDD\|366133	pfam00498, FHA, FHA domain. The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.	3.93585e-14
NC_018681.1\|WP_014981277.1\|518948_519371_+\|aspartate-1-decarboxylase	gnl\|CDD\|376751	pfam02261, Asp_decarbox, Aspartate decarboxylase. Decarboxylation of aspartate is the major route of beta-alanine production in bacteria, and is catalyzed by the enzyme aspartate decarboxylase EC:4.1.1.11 which requires a pyruvoyl group for its activity. It is synthesized initially as a proenzyme which is then proteolytically cleaved to an alpha (C-terminal) and beta (N-terminal) subunit and a pyruvoyl group. This family contains both chains of aspartate decarboxylase.	3.9831e-80
NC_018681.1\|WP_014981282.1\|523338_523698_+\|Lsr2-family-protein	gnl\|CDD\|378714	pfam11774, Lsr2, Lsr2. Lsr2 is a small, basic DNA-bridging protein present in Mycobacterium and related actinomycetes. It is a functional homolog of the H-NS-like proteins. H-NS proteins play a role in nucleoid organisation and also function as a pleiotropic regulator of gene expression.	1.94563e-46
NC_018681.1\|WP_014981273.1\|515009_515486_+\|DUF3180-domain-containing-protein	gnl\|CDD\|378650	pfam11377, DUF3180, Protein of unknown function (DUF3180). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.	2.36569e-34
NC_018681.1\|WP_029900679.1\|521002_521425_+\|sulfurtransferase	gnl\|CDD\|238724	cd01447, Polysulfide_ST, Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a terminal electron acceptor. The active site contains the same conserved cysteine that is the catalytic residue in other Rhodanese Homology Domain proteins.	3.89896e-13
NC_018681.1\|WP_041562361.1\|507615_508452_+\|DUF1266-domain-containing-protein	gnl\|CDD\|377728	pfam06889, DUF1266, Protein of unknown function (DUF1266). This family consists of several hypothetical bacterial proteins of around 235 residues in length. Members of this family seem to be found exclusively in the Enterobacteria Salmonella typhimurium and Escherichia coli. The function of this family is unknown.	7.77355e-33
NC_018681.1\|WP_014981265.1\|507226_507487_-\|DUF2277-domain-containing-protein	gnl\|CDD\|378364	pfam10041, DUF2277, Uncharacterized conserved protein (DUF2277). Members of this family of hypothetical bacterial proteins have no known function.	1.72927e-24
NC_018681.1\|WP_014981284.1\|524682_525279_+\|DUF1772-domain-containing-protein	gnl\|CDD\|227787	COG5500, COG5500, Predicted integral membrane protein [Function unknown].	2.51262e-17
NC_018681.1\|WP_014981272.1\|514470_515013_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	gnl\|CDD\|223872	COG0801, FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [Coenzyme metabolism].	1.05964e-49
NC_018681.1\|WP_014981276.1\|517993_518923_+\|pantoate--beta-alanine-ligase	gnl\|CDD\|234741	PRK00380, panC, pantoate--beta-alanine ligase; Reviewed.	1.44998e-150
NC_018681.1\|WP_014981281.1\|521723_523223_+\|lysine--tRNA-ligase	gnl\|CDD\|234778	PRK00484, lysS, lysyl-tRNA synthetase; Reviewed.	0
NC_018681.1\|WP_081593878.1\|515556_516600_+\|hypothetical-protein	gnl\|CDD\|374080	pfam15754, SPESP1, Sperm equatorial segment protein 1.	1.00616e-05
NC_018681.1\|WP_014981271.1\|514036_514474_+\|dihydroneopterin-aldolase	gnl\|CDD\|376737	pfam02152, FolB, Dihydroneopterin aldolase. This enzyme EC:4.1.2.25 catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin in the biosynthetic pathway of tetrahydrofolate.	4.82259e-44
NC_018681.1\|WP_041562362.1\|520370_520994_+\|cysteine-dioxygenase-family-protein	gnl\|CDD\|380416	cd10548, cupin_CDO, cysteine dioxygenase, cupin domain. This family contains cysteine dioxygenase (CDO; EC 1.13.11.20), which catalyzes the conversion of cysteine to cysteine sulfinic acid, the first step in the biosynthesis of essential oxidized cysteine metabolites such as sulfate, hypotaurine, and taurine. CDO also plays an important role in the regulation of intracellular cysteine levels in mammals; CDO expression is altered in cancer cells, and abnormal or deficient CDO activity has been linked to Parkinson's disease, Alzheimer's disease, and rheumatoid arthritis. CDO is an iron-dependent thiol dioxygenase that uses molecular oxygen to oxidize the sulfhydryl group of cysteine to generate cysteine sulfinic acid. The CDO active site contains an amino acid-derived cofactor. These enzymes are found in prokaryotes as well as eukaryotes and belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	2.56561e-16

>NC_018681.1|WP_081593878.1|515556_516600_+|hypothetical-protein
MVSPSRTSTSRRRREDAGKFFIGVLILLGLVASVFLIFSNSLQYVRIGLVAALWAAVIGALAATRYRKEATIDKAKVRDLQTVYELQLEREVTARREFELGLEARVREEVGADAAELAALRAELTVLRQSLQRLFDGDLLMERPALRADATRIQELTSTVGDPANNSSTNAGVWSYGPNQQPRSSVTPVFTPDHPEPPAFASPFDDPVTAETSVVSLDDETDAEITDINIAAEPVEPAEPADEDAAAASHGWADAFTESPVVEQTPDPEPTPPPAPKPPVTPWPIASTPSTRPSAWPTTTSPAVGTASSRRRRRAEPDTDSATPERRLSVAEIMANLQSEEQSRDRR
>NC_018681.1|WP_014981273.1|515009_515486_+|DUF3180-domain-containing-protein
MKLKPTRVLDLVANVVIAAIVAWIATRMAYNSFPPISIFAGASLYPVAAIEAVLAFVIRSRVNDNDLGNGRHQLHPITAARAVALAKASLQVGSIAAGVWLGFLCWVFPQRGTLGAAAADSPGAIVGMLAGVALVAAALWLEYCCRAPEDPTDDPATT
>NC_018681.1|WP_014981272.1|514470_515013_+|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase
MSRAVLSVGSNLGDRLAHLRSVVHGFGDRVVAVSPVYSTAPWGGVEQDDYLNAIVVAEDPELGCLDWLRRGQALEQAAERVREVRWGPRTLDVDVIWCAERSGDGLVARSSTDPVLTLPHPQAHRRAFVLMPWRDLEPDATLEVDGGARRIADLLAELPAADRAGVHRTDLVLTAEGPVR
>NC_018681.1|WP_014981271.1|514036_514474_+|dihydroneopterin-aldolase
MSGTRTDAARPAARQDAPIGRGATRIELRGLRAFGYHGVFEHERRDGQEFVVDLTVWVDFARAVATDDIADTVHYGELADNAVRIIEGPPRNLIETVVSEIADDVMTDPRITAVEVVVHKPSAPIPHTFADVRVVAARHREEQQE
>NC_018681.1|WP_051066879.1|513197_514040_+|dihydropteroate-synthase
MGVVNVTSDSFSDGGRYLDPEVAIAHGVELYAAGADIIDVGGESTRPGAVRVDPDTEAGRVVPVIRGLVAAGVPTSVDTMRAGVAEAALAAGVSVVNDVSGGRADPDMVKVVAAAEVPWILMHWRAGADYRHTGPADHYDDVVAEVRAELAGQVDLAVAAGVDPARLILDPGLGFAKNAEHNWDLLGALPELVEAGLPVLIGASRKRFLGALLAGDSGPRPPDGRETATATISALAAMHGAWGVRVHDVRASLDAITVTDTWQRAAAARAGRPSSLGAHR
>NC_018681.1|WP_171904449.1|512470_513076_+|GTP-cyclohydrolase-I-FolE
MTGPELVALETGRPFDQARAEAAVRELLIAVGEDPDRPGLVDTPARVARAYREMFAGLYVEPDAVLNTTFDEGHQELVLVRDIPLYSTCEHHLVSFHGVAHVGYIPGKHGRVTGLSKLARVVDLYAKRPQVQERLTSQIADAVMRKLDPRGAIVVVEAEHLCMAMRGIRKPGASTTTSAVRGLLQSSPSSRAEALDLILRK
>NC_018681.1|WP_014981268.1|509842_512248_+|ATP-dependent-zinc-metalloprotease-FtsH
MNRKTVFRTLAIVSGILLVIYAFSYFGNDTRGWKNVDTSVALSQLTDKNNVKNVQIDDREQQLRIELKNGNDATSGESKIIAKYPGGSETSSQVFDAVKNSGAPYNTVVKQESWLTQILLFVLPMIILLGLFIFVMARMQGGGRGGMMGFGKSKAKQLSKDMPKTTFADVAGADEAVEELYEIKDFLQNPVRYQALGAKIPKGVLLYGPPGTGKTLLARAVAGEAGVPFFTISGSDFVEMFVGVGASRVRDLFEQAKQNSPCIIFVDEIDAVGRQRGAGLGGGHDEREQTLNQLLVEMDGFGDRTGVILIAATNRPDILDPALLRPGRFDRQIPVGNPDLAGRRAILRVHSQGKPISPDADLDGLAKRTVGMSGADLANVINEAALLTARENGAVITGESLEESVDRVVGGPRRKSRIISEHEKKITAYHEGGHTLAAWAMPDIEPVYKVTILARGRTGGHAMTVPEDDKGLMTRSEMIARLVMAMGGRAAEELVFHEPTTGASSDIDQATKIARAMVTEYGMSARLGAVRYGQEAGDPFLGRSMGQSSDYSHEVAGAIDEEVRNLIEAAHTEAWAILNEYRDVLDVLATALLERETLHRKELETLLATVEKRPRITAFNDFGDRVPSSKPPVKTPGELALERGEPWPPPEQVPAPLPAGAAREGQPANGYPDDGGYHAQPQYGYPAQPATGYPLPQAPAPGYPQRGGTHGSRPDYGAPAGWSAPGWPPREEQQSGQPSGWTEQPQRGGHQQWAPPQGGPQDGNYDRRGSYGDRPGYDEQGRPNQNGEGENNEWDGPNGRH
>NC_018681.1|WP_051066471.1|508536_509484_-|hypothetical-protein
MDIVELRTPTAIVRHGRGRLIVLRPGSDGERVLDVPVSDLLKVRLNRRADDAVVIEIYLRYPTPVLTGVPADRTPLPVLIAEHDVPAASEIVDRINSQILSTQRIDVAAPDLNPPAPSWGKSGPTRADVERAVRRMAPHREAKAAIAALHRYVTPDEYVLETAIAVAHAPAGSGSGLLAATTGRLLFISIGAGSRYAHELPIPAVLWARNTDGTPVAAGEIGSPRGEAGMEVHDGNVTLRFTGADRADTERVTLAVNFAVRRDSADGAAGPADPGVAQLYSEWELLVERHSLGMVDDAQFQRYGRGILRSLPDGG
>NC_018681.1|WP_041562361.1|507615_508452_+|DUF1266-domain-containing-protein
MPARGVPTLTTFPYDELDQREEDHWSGAAVADDELRALALGAFYSARWDAFHDALLLGPEREHPLGDRRELAIDTLTGAWGITDGTEAQASMEQLLDGMHAPLYALVHPLVMASINASERDRFGERADRHRAFLRQVGSFRGMDNPEALVRDYDIWSQAIKIGFTDHLARPLPSDIHAWDLARVVAVARMAFTAGYLDADLAWDYLARALPIAQAKYRNWRQFGDAYLTGWTYWQACEDLAELKNGGVDRRMELLRLWMRPTSPWRRISLTPMPVAQA
>NC_018681.1|WP_014981265.1|507226_507487_-|DUF2277-domain-containing-protein
MSSNITLLRGLEPAATEQEIYAAALQYVRTVGGVSGLSSTTKAAVDKAVTAIAAATTQLLADLPDRPAVAPTEPPLRRVAAGEAAE
>NC_018681.1|WP_081593879.1|516992_517994_+|DUF2520-domain-containing-protein
MAKRPVPAWRDWNDIERTTLTSRSVNSDDAPSSYDPAPARLTVGIVSAGRVGSALGVALERAGHVVFGTAAISDASVHRARTRLPDSEILPVEDVAVRSELLLLAVPDTELAGLARGLASAKAVRPGTIVAHTSGANGIGVLAPLAEVGALPLAIHPAMTFTGHDEDITRLGNACFGITAADEIGYAIAQALVIEMGGEPVRVPEEHRALYHAALAHGSNHLVTVIVDAVAALRVALSGPGLLGQQVVDDQPNGLAERLLAPLASAALDNALRRGQSALTGPVARGDADAVAAHLRALESVDPRLAEGYRALSLRTAERAGTNPAVIELLKGR
>NC_018681.1|WP_014981276.1|517993_518923_+|pantoate--beta-alanine-ligase
MFDPKLRGAFKPGELTVHHDPAVLTQVSNALRGVGRTVALVPTMGALHEGHLEIVRQAKKTNQVVIVSIFVNPLQFGANEDLDKYPRTLDADVALLRAEGVELVFAPSVSDMYPDGPRTTVQPGPIGAELEGASRPTHFAGMLTVVAKLLQIARPSEVYFGEKDYQQLTLIRQLVRDLNFDVRIKPVVTVREPDGLAMSSRNRFLDAAQRESALALSAALAAGKHAGGLGAEAVLAAARQVLDAASGVDVDYLELRSANLEPAPTTGNARLLVAARVGQTRLIDNTAVTLGAPIDGHPNVSATRTSQPA
>NC_018681.1|WP_014981277.1|518948_519371_+|aspartate-1-decarboxylase
MLRTMMKSKIHRATVTHADLHYVGSVTVDQDLLDAADLLEGEQVCIVDIDNGARLETYVIAGERGSGVIGINGAAAHLVHPGDLVILIAYGQMNEQEIAEYDPKVVFVDERNRPVELGSDPAHAPEGSGLTSPRSLSFAG
>NC_018681.1|WP_014981278.1|519389_520187_+|type-III-pantothenate-kinase
MLLTIDVRNTHIVLGLFSGSGAHSKLVRHWRIHTNPLLTADEFAMQVRGLIGAQLDEVIGVSALSTVPPVLRELRTMLSQYWGQVPHVLVEPGVRTGIPLLVDNPKEVGADRIVNCLAAYQHYSSPTIVVDFGTAICVDLVSGKGEFLGGIIAPGVEISMEAVVERTAMRRVELTRPRSVVGKNSMECMQSAAVFGFAGMVDGLVDRIRDEFEAFAGDDVAVVATGPSAPLIVPESETIEDHDPYLTLTGLRLVYERNQRRKGAA
>NC_018681.1|WP_041562362.1|520370_520994_+|cysteine-dioxygenase-family-protein
MRSSVLSLSSARDDFSATPPLDRAVASALPTRLRPADLLRLTDEGAEDVLAGRYDHLLPANGIWPADERWAARLLADDEVDVWLISWTPGKSTELHDHAGSLGALTVLSGALSEFRWNGTELRRRILTAGDQASFPIGWVHDVMRAPAQSVTSTADAAATDPALLEPTLSVHAYSPPLTAMSYYEVTGHGTLRRSRTVLTDQPEGDM
>NC_018681.1|WP_029900679.1|521002_521425_+|sulfurtransferase
MTIDQMLDNARAQLTRIYAFELPKALARGAILVDIRPQAQRVREGALPGALVIERNVLEWRLDPSSSARLALATDHEIEWIIACSEGYTSSLAAASLQQLGLRRATDLVGGFHALKAAGLLHIGMRAPHFAREVAALASL
>NC_018681.1|WP_014981281.1|521723_523223_+|lysine--tRNA-ligase
MAPEADDAPEQIRIRKEKRERLLAAGGDAYPVVVPRTHTLAEIRAAYPDLAADTQTGLQAGVAGRVIFMRNTGKLCFATLQEGDGTKLQAMISLNGVGADALAAWKADVDLGDFVFVHGEVISSRTGELSVMADSWFMAAKSLRPLPVAHKEMNEESRVRQRYVDLIVRPEAREMARTRIAVVRALRNALERRGFLEVETPMLQTLHGGAAARPFVTHSNALDIDLYLRIAPELFLKRCVVGGLEQVFEINRNFRNEGSDSTHSPEFAMLETYQAYGTYDDSARMTRELVQEVAQEVFGTQVVTLADGTEYDLRGEWATVEMYPSLSDALGVSVTPETSIAELRALADRVGLEIPEGKGYGHGKLVEELWEHQYGDKLYAPTFVRDFPVETSPLTRQHRSAAGVTEKWDLYVRGFELATGYSELVDPVIQRERFVDQARLAAQGDDEAMALDEDFLAAMEHGMPPTTGTGMGIDRLLMALTGLGIRETILFPIVRPVTR
>NC_018681.1|WP_014981282.1|523338_523698_+|Lsr2-family-protein
MAKKVTVSLIDDVDGESIADETIEFAIDGVSYEIDLSSANAAKLRDGLEEWVSSARRVSGRRRVKAAATATGAPKGRVSIDREQSAAIRDWARRNGHKVSARGRISADITDAYNKAAKG
>NC_018681.1|WP_042254905.1|523906_524554_+|FHA-domain-containing-protein
MERRGIGAVTGFVGSFLRFQDDTGRQQEFMLTPEQERITIGRSPQADLALSWDAEVSRLHAAIEYLGAQWTIVDDGLSRNGTFVNGDRLVGRRRLMAGDVIRVGTSRVSFHDFGGVADDITRTSTGSTPTTSQLTDTQRSVLIALCRPYKNGAAFATPASNQQIAEELFLSVDAIKTHLRVLFGKFGVEDLPQNAKRVRLAFLAIQSGLISDRDL
>NC_018681.1|WP_014981284.1|524682_525279_+|DUF1772-domain-containing-protein
MTAARLIALVLATLATGLIAGLFYGYANSVMPALNRTDDRTMIDVMQKINVVIINPVFMIGFLGTVGFSILAALLHLGKDQRTVLLWIGVGLVINVIAFAVTSGLNVPLNNQLAAAGDVAQIADLAAVRADFEAVWVRWNIVRAVLHTLAFLVLCGALFVAGIQHGKANAAAGPAATGPQAAQGQFPGQPGVAAYRQG

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Click the colored protein region to show detailed information

Crispr_ID: NC_018681_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_018681_3

632951-633052

Orphan

Consensus_repeat	Method
CAGCGAGGTGCAGGCATGAGTGAGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_018681_3

>merge|NC_018681|3|632951-633052|CRISPRCasFinder
CAGCGAGGTGCAGGCATGAGTGAGTGGAGCGATCGAATCGTGTCACAGCGTGCGTCGCGCATGCCGGAGCCGAGCGCCAGCGAGGTGCGGGCATGAGTGAGT

>NC_018681|3|2|632951-633052|CRISPRCasFinder
CAGCGAGGTGCAGGCATGAGTGAGT	GGAGCGATCGAATCGTGTCACAGCGTGCGTCGCGCATGCCGGAGCCGAGCGC
CAGCGAGGTGCGGGCATGAGTGAGT

Protein	Signature genes	Signature genes Name	Protein_function
NC_018681.1\|WP_014981387.1\|626343_627414_-\|nitronate-monooxygenase	unknown	unknown	gnl\|CDD\|367316
NC_018681.1\|WP_014981403.1\|642951_643989_+\|LLM-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274647
NC_018681.1\|WP_014981397.1\|636972_638232_+\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035
NC_018681.1\|WP_014981390.1\|629091_629856_-\|enoyl-CoA-hydratase-family-protein	unknown	unknown	gnl\|CDD\|181174
NC_018681.1\|WP_014981396.1\|635669_636833_-\|steroid-3-ketoacyl-CoA-thiolase	unknown	unknown	gnl\|CDD\|181145
NC_018681.1\|WP_014981395.1\|633554_634565_+\|hypothetical-protein	unknown	unknown	unknown
NC_018681.1\|WP_051066474.1\|640781_641867_-\|thiolase-domain-containing-protein	unknown	unknown	gnl\|CDD\|181173
NC_018681.1\|WP_041562376.1\|641832_642801_-\|OB-fold-nucleic-acid-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|224462
NC_018681.1\|WP_014981388.1\|627410_628196_-\|CoA-transferase	unknown	unknown	gnl\|CDD\|224968
NC_018681.1\|WP_081593881.1\|628192_629077_-\|CoA-transferase-subunit-A	unknown	unknown	gnl\|CDD\|224702
NC_018681.1\|WP_014981385.1\|625284_625671_+\|hypothetical-protein	unknown	unknown	unknown
NC_018681.1\|WP_014981386.1\|625750_626197_-\|heavy-metal-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|179252
NC_018681.1\|WP_041563335.1\|638722_639613_-\|TIGR03619-family-F420-dependent-LLM-class-oxidoreductase	unknown	unknown	gnl\|CDD\|274680
NC_018681.1\|WP_014981398.1\|638306_638726_-\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|238404
NC_018681.1\|WP_014981400.1\|639618_640785_-\|thiolase-domain-containing-protein	unknown	unknown	gnl\|CDD\|181378
NC_018681.1\|WP_041563332.1\|624010_625165_+\|acetyl-CoA-C-acetyltransferase	unknown	unknown	gnl\|CDD\|181123
NC_018681.1\|WP_014981393.1\|632005_632878_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NC_018681.1\|WP_014981391.1\|629938_630730_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|236116
NC_018681.1\|WP_011207048.1\|634890_635307_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|376540
NC_018681.1\|WP_014981392.1\|630762_631674_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|236099

Protein	Function_ID	Function_description	E-value
NC_018681.1\|WP_014981387.1\|626343_627414_-\|nitronate-monooxygenase	gnl\|CDD\|367316	pfam03060, NMO, Nitronate monooxygenase. Nitronate monooxygenase (NMO), formerly referred to as 2-nitropropane dioxygenase (NPD) (EC:1.13.11.32), is an FMN-dependent enzyme that uses molecular oxygen to oxidize (anionic) alkyl nitronates and, in the case of the enzyme from Neurospora crassa, (neutral) nitroalkanes to the corresponding carbonyl compounds and nitrite. Previously classified as 2-nitropropane dioxygenase, but it is now recognized that this was the result of the slow ionization of nitroalkanes to their nitronate (anionic) forms. The enzymes from the fungus Neurospora crassa and the yeast Williopsis saturnus var. mrakii (formerly classified as Hansenula mrakii) contain non-covalently bound FMN as the cofactor. Active towards linear alkyl nitronates of lengths between 2 and 6 carbon atoms and, with lower activity, towards propyl-2-nitronate. The enzyme from N. crassa can also utilize neutral nitroalkanes, but with lower activity. One atom of oxygen is incorporated into the carbonyl group of the aldehyde product. The reaction appears to involve the formation of an enzyme-bound nitronate radical and an a-peroxynitroethane species, which then decomposes, either in the active site of the enzyme or after release, to acetaldehyde and nitrite.	8.32984e-84
NC_018681.1\|WP_014981403.1\|642951_643989_+\|LLM-class-F420-dependent-oxidoreductase	gnl\|CDD\|274647	TIGR03559, F420_Rv3520c, probable F420-dependent oxidoreductase, Rv3520c family. Members of this protein family are predicted to be oxidoreductases dependent on coenzyme F420. The family includes a single member in Mycobacterium tuberculosis (Rv3520c/MT3621) but four in Mycobacterium smegmatis. Prediction that this family is F420-dependent is based primarily on Partial Phylogenetic Profiling vs. F420 biosynthesis. [Unknown function, Enzymes of unknown specificity].	2.67433e-179
NC_018681.1\|WP_014981397.1\|636972_638232_+\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	6.30097e-90
NC_018681.1\|WP_014981390.1\|629091_629856_-\|enoyl-CoA-hydratase-family-protein	gnl\|CDD\|181174	PRK07938, PRK07938, enoyl-CoA hydratase family protein.	2.48699e-160
NC_018681.1\|WP_014981398.1\|638306_638726_-\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|238404	cd00781, ketosteroid_isomerase, ketosteroid isomerase: Many biological reactions proceed by enzymatic cleavage of a C-H bond adjacent to carbonyl or a carboxyl group, leading to an enol or a enolate intermediate that is subsequently re-protonated at the same or an adjacent carbon. Ketosteroid isomerases are important members of this class of enzymes which are the most proficient of all enzymes known and have served as a paradigm for enzymatic enolizations since its discovery in 1954. This CD includes members of this class that calalyze the isomerization of various beta,gamma-unsaturated isomers at nearly a diffusion-controlled rate. These enzymes are widely distributed in bacteria.	4.91547e-12
NC_018681.1\|WP_051066474.1\|640781_641867_-\|thiolase-domain-containing-protein	gnl\|CDD\|181173	PRK07937, PRK07937, lipid-transfer protein; Provisional.	0
NC_018681.1\|WP_041562376.1\|641832_642801_-\|OB-fold-nucleic-acid-binding-domain-containing-protein	gnl\|CDD\|224462	COG1545, COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only].	9.22965e-36
NC_018681.1\|WP_014981396.1\|635669_636833_-\|steroid-3-ketoacyl-CoA-thiolase	gnl\|CDD\|181145	PRK07850, PRK07850, steroid 3-ketoacyl-CoA thiolase.	0
NC_018681.1\|WP_081593881.1\|628192_629077_-\|CoA-transferase-subunit-A	gnl\|CDD\|224702	COG1788, AtoD, Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism].	7.56633e-66
NC_018681.1\|WP_014981386.1\|625750_626197_-\|heavy-metal-binding-domain-containing-protein	gnl\|CDD\|179252	PRK01217, PRK01217, hypothetical protein; Provisional.	1.72253e-48
NC_018681.1\|WP_041563335.1\|638722_639613_-\|TIGR03619-family-F420-dependent-LLM-class-oxidoreductase	gnl\|CDD\|274680	TIGR03619, F420_Rv2161c, probable F420-dependent oxidoreductase, Rv2161c family. Coenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H, Rhodopseudomonas palustris HaA2, and others. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxygenanases (pfam00296), that appear only in F420-positive genomes and are likely to be F420-dependent. This model describes a domain found in a distinctive subset of bacterial luciferase homologs, found only in F420-biosynthesizing members of the Actinobacteria. [Unknown function, Enzymes of unknown specificity].	1.62857e-62
NC_018681.1\|WP_014981400.1\|639618_640785_-\|thiolase-domain-containing-protein	gnl\|CDD\|181378	PRK08313, PRK08313, thiolase domain-containing protein.	0
NC_018681.1\|WP_041563332.1\|624010_625165_+\|acetyl-CoA-C-acetyltransferase	gnl\|CDD\|181123	PRK07801, PRK07801, acetyl-CoA C-acetyltransferase.	0
NC_018681.1\|WP_014981393.1\|632005_632878_+\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	7.38852e-06
NC_018681.1\|WP_014981391.1\|629938_630730_+\|SDR-family-oxidoreductase	gnl\|CDD\|236116	PRK07856, PRK07856, SDR family oxidoreductase.	1.4745e-146
NC_018681.1\|WP_011207048.1\|634890_635307_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|376540	pfam01381, HTH_3, Helix-turn-helix. This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within Neisseria gonorrhoeae NGO_0477, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteristic of the whole family.	4.8364e-05
NC_018681.1\|WP_014981392.1\|630762_631674_+\|SDR-family-oxidoreductase	gnl\|CDD\|236099	PRK07791, PRK07791, short chain dehydrogenase; Provisional.	1.30295e-163
NC_018681.1\|WP_014981388.1\|627410_628196_-\|CoA-transferase	gnl\|CDD\|224968	COG2057, AtoA, Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism].	4.38356e-34

>NC_018681.1|WP_014981393.1|632005_632878_+|hypothetical-protein
MPTNPAIGTGSATGSAAAGGSAAAGSAAAGGSAAGGSAAAAGSAGLGIVLGSGSAGLGLTLGSGSAGLGVVLGSGSAALAATGSAGLGAAATGSAAVGSAGVGVGTTGSAAVGSAGVGSAAVGSAGVGSAGVGSAGVGSAATGSAAVGSAAVGSAAVGSAAPLLLLLIPIPAPPAPVLPPIAVPPVPSPVLPAIPLPVLAPVPAAAPAAVPPPAPPAPAAPPQASPAKPNPDVRPTSADDGLPKPKLLSVIGGLIALGLAGAGSGAVSFQGASAAQARVDAARAMFFPRP
>NC_018681.1|WP_014981392.1|630762_631674_+|SDR-family-oxidoreductase
MDTEQICAGRTVIVTGAGRGIGRAHALAFAAAGARVVVNDLGSALDGAATGETPAEQVVAEIEALGGAAVANGDDVADWQGAQRLVRQAVDTFGGLDVLVNNAGFVRDRMLVNLGEDEWDAVIRVHLKGHFVTMRHAIEYWRGESKAGRPVDGRIINTSSGAGLQGSVGQGNYGAAKAGIAGLTLTAAAEFARYGVTVNSIAPAARTRMTETVFAETMARPDAGFDTMAPENISPLVVWLGSAQSKDVTGRMFEVEGGKVALADGWRHGVAVDRGARWDPAELGPVVADLIAKGMPPEPVYGA
>NC_018681.1|WP_014981391.1|629938_630730_+|SDR-family-oxidoreductase
MTLEIDLVDRVVLVTGGVRGVGAGVSRTFLAAGATVIACARRPAEAPIEVDGRAIEFLPCDVRDADAVQGLVDTVVERHGRLDHLVNNAGGAPFALADTASKNFHAKIVELNLLAPLLVAQAANTVMQQQPGGGSIVNISSVSGHRPSPGTAAYGAAKAGMDSLTASLAVEWAPKVRVNSLVVGPVVTELSQLHYGDQDGIDAVGETIPLGRMAHPDDIGRCAVFLASALAGYVSGASLLVHGGGERPAFLAASTADAGRQQS
>NC_018681.1|WP_014981390.1|629091_629856_-|enoyl-CoA-hydratase-family-protein
MGINRHSESTGITVVTVDYPPVNAIPTDGWFAIADALREAGRDPETRVVVLRAENRGFNAGVDIKEIQSKPGHQALIDANHGCFEAFAAVYDCPVPVIAVVQGFCLGGGIGLVGNADVVIASDDATFGLPEVDRGALGAATHLSRLVPQHLMRALFYTASTITAQQLQHFGSVYQVVPRAELDAAAMEVAKNIAAKDGRVIRAAKRALNGIDGQDVHRSYRYEQGFTFELNLAGVADEIRARFDDDLAARKAEK
>NC_018681.1|WP_081593881.1|628192_629077_-|CoA-transferase-subunit-A
MRDKRMSLDEVVGELRSGMTLGIGGWGSRRKPMALVRAILRSDLTDLTVVSYGGPDLGLLCSAGKVRKAYYGFVSLDSPPFYDPWFAHARTTGALVAREMDEGMLKCGLEAAAARLPFLPIRAGLGSDVPNFWDGELRTVASPYPDADGRTETLIAMPALNLDAALVHLNLGDQHGNAAYTGVDPYFDDLYCLAAERRYVSVERIVDTDELVKTVPLQSLLLNRMMVDGVVEAPGGAHFTLASDSYGRDEKFQKHYVQSAKTPETWQQFVDKYLAVSEDEYQAAVREFAQEAQK
>NC_018681.1|WP_014981388.1|627410_628196_-|CoA-transferase
MTAAQGDSVAGTAETCTRAEVCAVACAEIFSGAGEIMASPMSPMSIIGARLAKLTTEPDLLLSDGEALLFAGTPPLGGKAPIEGWIPFRKVFDVVASGRRHVVMGANQIDRYGNQNLSAFGALQQPTRQMFGVRGAPGNTLNHATSYWVSRHTSRVFTDQVDIVSGVGYDKVDPANPAYRFHHLHRVVTNLGVFDFTGPGHTMRARSLHPGVTAAEVAENTGFEIDGLAEAGETRLPTAEELRLIRDVLDPKKIRETEVPA
>NC_018681.1|WP_014981387.1|626343_627414_-|nitronate-monooxygenase
MSAPTPRLRTALTELVGIDHPVVQTGMGWVAGPSLVAATAEAGGLGILASATMTYAELEAAIAKTKAHTAKPFGVNIRADASDAPERIDLLISEKVAVASFALAPKQELIAKLKDAGVVVIPSIGAAKHAVKVASWGADAVIVQGGEGGGHTGPVATTLLLPSVLDAVDIPVVAAGGFFDGRGLAAALSYGAAGVAMGTRFLLTQESTVPDAVKKEYLTRQLQDTVVSTKVDGMPHRVLNTELVQRLEHSGRARGLAAAVANAAKFKSMTGMKWSTLVRDGLSMRKAKDLSWSQVVMAANTPMLLRAGLVEGNTGAGVLAAGQVTGIIEDLPTCKELIDRIVADAVGRIEALQKNL
>NC_018681.1|WP_014981386.1|625750_626197_-|heavy-metal-binding-domain-containing-protein
MNQPMPPQQPHYPQQQPGFQQPPPGYQQPPQQQPGPQFPILVSTMNDVPGHRVVRVFGEVAGLTVRSRGLGSNLAAGFRSLGGGEITEYTQLLYHSRHEAIMRMCQHAMSFGANGILAMRFDCNEIANTMSEVAAYGTAVLLEPAEKN
>NC_018681.1|WP_014981385.1|625284_625671_+|hypothetical-protein
MELLLQIEGLPVAAVVRGATATIRFGEPDTFELQIEGELTFRTSTGSVLQAPSNDYAVVAAELESLIGSVVTRADASESDGLILEFSSGAAIHVPIDKDYEAWGIVGRDGSRVICTPGGEFAIWSANK
>NC_018681.1|WP_041563332.1|624010_625165_+|acetyl-CoA-C-acetyltransferase
MRDAYVIDAVRTPVGKRGGALAAVHPADLGAAALRGLLDRHSIDPGNVDDVIVGCVDNVGPQAGNVGRTAWLAAGYPEEVPGVTVDRQCGSSQQAINFGAQAIMSGTAEVIVAGGLQNMSAIPISAAMYAGKEYGFESPFVGAAGWDHRYGTAEVTQFRAAQLIAEKWGISREDMERWALRSHERARDAIKNGRFDREIVPVGDFWIDQGPRETTLEKMASLPPLAEGSPLTAAVASQISDGASATLLASDWAVETYGLTPRARIHHVSARGADPIFMLTAPIPATKWALEKTGLTIEDIDVIEINEAFAPVVLAWLKETGADPEKVNVNGGAIALGHPLGATGAKLFATLLNELERRNGRYGLLTICEGGGTANVTIIERLPH
>NC_018681.1|WP_014981395.1|633554_634565_+|hypothetical-protein
MTLWLTALLVWMAAGARVGRVLVKPATTARVAIVIAVAAVALAATVAVPEIAVAIDNLLPGGVHAGWLSDGVVVSAWIAFVTATSVVASAAWPVVSRRNLRQVALVIYSLGLFAVAATIAWSFTFGWEVVAFGAVFIVITGLRNLDWTTLGRGIAIYTTGTAVVAVLAALQVRRAFNDTPRVAPGNPTWAWPAWEAASLLIAFGAVWIVVELWVRARVLLRQIRLLHKIMVGRFPEVVAHDQTGTSTQLRASDQVAQIMDALYLQSGGGVVLAAVAPPPRSIAERAGTVAEWARNPLGDVAIDARWIAPPEGISPRGWVQAIARAYDATSLEHARN
>NC_018681.1|WP_011207048.1|634890_635307_-|helix-turn-helix-domain-containing-protein
MADFAARLNKLFETVHPPGRKPHTNAEVAAALTASGHPISKPYLSQLRSGQRTNPSDETVAALAKFFKVKPDYFFNDIYAAKIDHDLELLSQLQGYGLRRLSSRAFDLSEESQNLLTSMAEKLRASEGLPEIPPDGTE
>NC_018681.1|WP_014981396.1|635669_636833_-|steroid-3-ketoacyl-CoA-thiolase
MGTPVIVEAARTPIGKRGGWLSGLHAAELLGLAQRGLLERAHLDPAQVEQVIGGCVTQAGEQSNNVTRVAWLHAGLPWQVGATTIDTQCGSAQQANHLVAGLIATGAIDVGIACGVEAMSRVPLGANVGEHAGARRPASWNIDLPNQFEAAERIAKRRGITRADVDEFGARSQRLAGQAWAEGRFDREVLTITAPAVDKEGNATGEKLDVSRDQGLRETTVEGLAKLKPVLEGGVHTAGSSSQISDGAAAVLLMDEQAAQRAGLRPRARIVTQALVGSEPEFHLDGPVQACTRLLERSGMSIGDIDLFEINEAFASVALSWASVHRPDLDRVNVNGGAIALGHPVGSTGSRLITTALHELERTGNSTAMVLMCAGGALATGTIIERL
>NC_018681.1|WP_014981397.1|636972_638232_+|cytochrome-P450
MVDPRNVRPNLPDGFDVTDPGIYAERVPVEEFAELRRTAPVWWNPQPAEVSGFHDEGFWVVSKHADVKEVSRRSEVFSTYENTAIPRFNDDITREQIELQRFVLINKDAPEHTKLRKIISRGFTPRAINGLRAELSARAESIVKAAAESGSGDFVTQIACELPLQAIAELIGVPQEDRMKVFTWSNDMTGYDDPDNDADPVMASAEILGYAYQMAAARKECPANDLVTTLIEADVDGDKLSEEEFGFFVIMLAVAGNETTRNAITHGMNAFMEHPEQWELFKKERPATAADEIIRWATPVTSFQRTALEDTELGGVQIKKGERVVMLYRSANFDEDVFDEPEKFDILRKDNQHLSFGGTGAHFCIGANLARLEVDLIFNAIADHLPDITKLGDPKRLRSGWLNGIKEFPVDYKTCPVAH
>NC_018681.1|WP_014981398.1|638306_638726_-|nuclear-transport-factor-2-family-protein
MTTTTDHPARTAGLASQAAVRARDKAAWVALFAEDGIVEDPIGPSGFDPEGKGHRGKEAIAAFWDKAIAQTTSIEFLFGDSFACGNEIAFTGTIRSTLGGHRIDADGVFTYRVDETGKIAALRAFWEVDRAMATAKKVD
>NC_018681.1|WP_041563335.1|638722_639613_-|TIGR03619-family-F420-dependent-LLM-class-oxidoreductase
MQFTLGIALSPLEQLPELAKTAEECGFSSVALPDSLFYMQSAAAKYPYTADGSRFWGPETPWVDPLIGATAMAMATSRIRFYTNVLKLGSRNPLLLARQVGSVAAMSGNRFGFGVGIGWAPEEFEWCGVPYARRGARVDEMIEVIKLVLGGGMVEYHGEFFDFDPLQVSPAPTEPVPFYIGGHTEAALRRAARVGDGWASAMMTYDELRRTIGKLDALRAEFGRGTEPFEIQAVCVDRFGRSGYQDLADAGVTDAIVVPWLMDGIGFDGELAAKQDSLRRFAAANIEDPIVAEVPA
>NC_018681.1|WP_014981400.1|639618_640785_-|thiolase-domain-containing-protein
MTNPAAVLGTGQTHHVTKRTDVSMAGMCREAIDRALVDAGLTIADIDAVVVGKAPDLFEGVMMPELYLADALGATGKPLLRVHTAGSVGGSTGVVAANLVQAGVHKRVLAIAWEKQSESNAMWALSIPVPFTMPVGAGAGGYFAPHVRSYIRRSNAPSHIGAMVAVKDRRNGAKNPLAHLKQPDITLESVLASQMLWDPIRFDETCPSSDGACAIVIGDEEAATAVEATGKKVAWVHGTAMRTEPTTFAGRDQVNPQAGQDAAAALWQAAGITDPLNEIDVAEIYVPFSWFEPMWLENLGFVPQGDGWKLTDKGETEIGGILPVNPSGGVLSSNPIGASGLIRFAEAAKQVMGRAGAYQVEGARKAVGHAYGGGSQYFSLWVVGSERR
>NC_018681.1|WP_051066474.1|640781_641867_-|thiolase-domain-containing-protein
MPTTRPTSTTSERPTLTDHGTDIAVVGFAHAPHVPETFGTTNGVEMLVPCFQQLYSRLGITKSDIGFWCSGSSDYLAGRAFSFISAIDAIGAVPPINESHVEMDAAWALYEAWVKLRSGQAETALVYGFGKSSAGTLRQVLTMQLDPYLVTPLWPDAWSIAGLQARAGLDAGRWTEQDMAAVAAGDDGDVESLLGTPYVADPLRAHDIAPVTDGAAAIVLAVGDRARELCERPAWITGMAHRVDTPNLGARDLTVSPSTAAAAQAVTGGDTSGFDIAELHAPFSHQQLILTEAIGLKNGTKVNPSGGALAANPMFAAGLERIGFAAEAIMGGTANRALAHATSGPALQQNLVTVLDSEASR
>NC_018681.1|WP_041562376.1|641832_642801_-|OB-fold-nucleic-acid-binding-domain-containing-protein
MNTTAPDVLSAPLRVQFDYTRSVGPTIGKFLTALRDRKIVGVRGTDGRVLVPPPEYDPVSAEPLTDFVDVAAVGTVESWTWVREPLPGQPFDRPFAWALIRLDGADTTLLHAVDIAAPEDIRTGMRVAVRWAAETSGSIHDIACFVPGEQPEATTEGTETGGDPISVITTPVDLSYKHTASPQETVYLRGLAEGKLLGGRTDAAGKVYFPPRGANPTDGRPTDQTVELPDRGTVTTFCIVNVPFLGQRIKPPYVAAYVLLDGADIPVLHLVLGCEASEVRMGMRVEAVWKPREEWGFGLENVDHFRPTGEPDADYETYKHHL
>NC_018681.1|WP_014981403.1|642951_643989_+|LLM-class-F420-dependent-oxidoreductase
MKFGLQLGYWMAQPPQHAGELVLAAEAAGFDAVFAAESWGSDAFGPLTWWGSATQRVRLGTSVVQMSARTPAATAMHALTLDHLSGGRAVLGLGVSGPQVVEGWYGQPFAKPLQRTREYVGIIRRILERAAPVTNDGPNYPLPYAGPGATGLGKPLKPIVHPLRADLPIWLGAEGPKNVALTAEIADGWLAIYYAPRLANMYNDWLDEGFARAGARRSRADFEIAASCQVVITDDAASELERMRWVMSLYIGGMGAPEQNFHAQVYRRMGYEREVDEIGRLFQAGKKAEAAAVVPDEMILDTAIIGDEAHVREQLKVWEAAGVTMMLVSAADVEQLRRLAPLVDM

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Crispr_ID: NC_018681_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_018681_4

671121-671260

Orphan

Consensus_repeat	Method
TTGTAAGCGAAAGGTCGTCAGTTCAATCCTGACAGGGGGCTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_018681_4

>merge|NC_018681|4|671121-671260|CRISPRCasFinder
TTGTAAGCGAAAGGTCGTCAGTTCAATCCTGACAGGGGGCTCGAGACGAGCGCGTCTGTAACGGCGCGCTCGTTCGGTCGGTAGAGGCCCTGCCTGATTTGTAAGCGAAAGGTCGTCAGTTCAATCCTGACAAGGGGCTC

>NC_018681|4|3|671121-671260|CRISPRCasFinder
TTGTAAGCGAAAGGTCGTCAGTTCAATCCTGACAGGGGGCTC	GAGACGAGCGCGTCTGTAACGGCGCGCTCGTTCGGTCGGTAGAGGCCCTGCCTGAT
TTGTAAGCGAAAGGTCGTCAGTTCAATCCTGACAAGGGGCTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_018681.1\|WP_041562378.1\|664999_665485_+\|h-domain-protein	unknown	unknown	gnl\|CDD\|319861
NC_018681.1\|WP_014981421.1\|662715_664143_+\|MCE-family-protein	unknown	unknown	gnl\|CDD\|224380
NC_018681.1\|WP_014981431.1\|672082_672460_-\|PH-domain-containing-protein	unknown	unknown	gnl\|CDD\|377953
NC_018681.1\|WP_141691826.1\|667741_669202_-\|trehalose-6-phosphate-synthase	unknown	unknown	gnl\|CDD\|340820
NC_018681.1\|WP_014981435.1\|676360_676999_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225767
NC_018681.1\|WP_086006214.1\|675068_676232_+\|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl\|CDD\|235596
NC_018681.1\|WP_041562381.1\|679341_679764_+\|HIT-domain-containing-protein	unknown	unknown	gnl\|CDD\|238608
NC_018681.1\|WP_014981427.1\|669385_669556_-\|hypothetical-protein	unknown	unknown	unknown
NC_018681.1\|WP_014981428.1\|669722_670556_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NC_018681.1\|WP_014981430.1\|671626_672052_-\|HIT-family-protein	unknown	unknown	gnl\|CDD\|223611
NC_018681.1\|WP_141691809.1\|673940_674942_-\|M23-family-metallopeptidase	unknown	unknown	gnl\|CDD\|366703
NC_018681.1\|WP_141691810.1\|678490_679084_+\|hypothetical-protein	unknown	unknown	unknown
NC_018681.1\|WP_014981432.1\|672621_673935_+\|phosphoribosylamine--glycine-ligase	unknown	unknown	gnl\|CDD\|234856
NC_018681.1\|WP_014981420.1\|661480_662719_+\|MCE-family-protein	unknown	unknown	gnl\|CDD\|273384
NC_018681.1\|WP_014981422.1\|664139_665003_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237081
NC_018681.1\|WP_014981436.1\|677005_678427_+\|adenylosuccinate-lyase	unknown	unknown	gnl\|CDD\|176471
NC_018681.1\|WP_011207082.1\|670726_670969_+\|MbtH-family-protein	unknown	unknown	gnl\|CDD\|225790
NC_018681.1\|WP_041562382.1\|679892_680852_+\|esterase-family-protein	unknown	unknown	gnl\|CDD\|223700
NC_018681.1\|WP_041562379.1\|666934_667672_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_018681.1\|WP_014981424.1\|665471_666938_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715

Protein	Function_ID	Function_description	E-value
NC_018681.1\|WP_041562378.1\|664999_665485_+\|h-domain-protein	gnl\|CDD\|319861	cd16385, IcmL, inner membrane protein IcmL/DotI. This family contains the periplasmic domain of the inner membrane protein DotI of the Dot/Icm (defect in organelle trafficking/intracellular multiplication) type IVB secretion system, including its ortholog in the conjugation system of plasmid R64, TraM, and similar proteins. These domains share striking structural similarity to the type IV secretion system (T4ASS) component VirB8 suggesting DotI/TraM to be its functional counterpart. DotI is essential for intracellular growth of Legionella pneumophila (causing agent of Legionnaires' disease) within mammalian and protozoan cells; it translocates numerous effector proteins into its eukaryotic host.	0.00698223
NC_018681.1\|WP_014981421.1\|662715_664143_+\|MCE-family-protein	gnl\|CDD\|224380	COG1463, Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism].	4.14455e-62
NC_018681.1\|WP_014981431.1\|672082_672460_-\|PH-domain-containing-protein	gnl\|CDD\|377953	pfam08000, bPH_1, Bacterial PH domain. This family contains many bacterial hypothetical proteins. The structures of Structure 3hsa and Structure 3dcx show similarities to the PH or pleckstrin homology domain. First evidence of PH-like domains in bacteria suggests role in cell envelope stress response.	6.91142e-66
NC_018681.1\|WP_141691826.1\|667741_669202_-\|trehalose-6-phosphate-synthase	gnl\|CDD\|340820	cd03788, GT20_TPS, trehalose-6-phosphate synthase. Trehalose-6-Phosphate Synthase (TPS, EC 2.4.1.15) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a nonreducing disaccharide present in a wide variety of organisms and may serve as a source of energy and carbon. It is characterized most notably in insect, plant, and microbial cells. Its production is often associated with a variety of stress conditions, including desiccation, dehydration, heat, cold, and oxidation. This family represents the catalytic domain of the TPS. Some members of this domain family coexist with a C-terminal trehalose phosphatase domain.	0
NC_018681.1\|WP_014981435.1\|676360_676999_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|225767	COG3226, COG3226, Uncharacterized protein conserved in bacteria [Function unknown].	1.18814e-25
NC_018681.1\|WP_086006214.1\|675068_676232_+\|pyridoxal-phosphate-dependent-aminotransferase	gnl\|CDD\|235596	PRK05764, PRK05764, aspartate aminotransferase; Provisional.	5.96648e-150
NC_018681.1\|WP_041562381.1\|679341_679764_+\|HIT-domain-containing-protein	gnl\|CDD\|238608	cd01277, HINT_subgroup, HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life. Although the biochemical function has not been characterised for many of the members of this subgroup, the proteins from Yeast have been shown to be involved in secretion, peroxisome formation and gene expression.	3.87952e-40
NC_018681.1\|WP_014981428.1\|669722_670556_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.16217e-30
NC_018681.1\|WP_014981430.1\|671626_672052_-\|HIT-family-protein	gnl\|CDD\|223611	COG0537, Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only].	3.19362e-33
NC_018681.1\|WP_141691809.1\|673940_674942_-\|M23-family-metallopeptidase	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	4.52478e-43
NC_018681.1\|WP_014981432.1\|672621_673935_+\|phosphoribosylamine--glycine-ligase	gnl\|CDD\|234856	PRK00885, PRK00885, phosphoribosylamine--glycine ligase; Provisional.	0
NC_018681.1\|WP_014981420.1\|661480_662719_+\|MCE-family-protein	gnl\|CDD\|273384	TIGR00996, Mtu_fam_mce, virulence factor Mce family protein. Members of this paralogous family are found as six tandem homologous proteins in the same orientation per cassette, in four separate cassettes in Mycobacterium tuberculosis. The six members of each cassette represent six subfamilies. One subfamily includes the protein mce (mycobacterial cell entry), a virulence protein required for invasion of non-phagocytic cells. [Cellular processes, Pathogenesis].	5.62481e-61
NC_018681.1\|WP_014981422.1\|664139_665003_+\|hypothetical-protein	gnl\|CDD\|237081	PRK12372, PRK12372, ribonuclease III; Reviewed.	0.00775233
NC_018681.1\|WP_014981436.1\|677005_678427_+\|adenylosuccinate-lyase	gnl\|CDD\|176471	cd03302, Adenylsuccinate_lyase_2, Adenylsuccinate lyase (ASL)_subgroup 2. This subgroup contains mainly eukaryotic proteins similar to ASL, a member of the Lyase class I family. Members of this family for the most part catalyze similar beta-elimination reactions in which a C-N or C-O bond is cleaved with the release of fumarate as one of the products. These proteins are active as tetramers. The four active sites of the homotetrameric enzyme are each formed by residues from three different subunits. ASL catalyzes two steps in the de novo purine biosynthesis: the conversion of 5-aminoimidazole-(N-succinylocarboxamide) ribotide (SAICAR) into 5-aminoimidazole-4-carboxamide ribotide (AICAR) and, the conversion of adenylsuccinate (SAMP) into adenosine monophosphate (AMP). ASL deficiency has been linked to several pathologies including psychomotor retardation with autistic features, epilepsy and muscle wasting.	0
NC_018681.1\|WP_011207082.1\|670726_670969_+\|MbtH-family-protein	gnl\|CDD\|225790	COG3251, COG3251, Uncharacterized protein conserved in bacteria [Function unknown].	1.70353e-33
NC_018681.1\|WP_041562382.1\|679892_680852_+\|esterase-family-protein	gnl\|CDD\|223700	COG0627, COG0627, Predicted esterase [General function prediction only].	1.40783e-60
NC_018681.1\|WP_041562379.1\|666934_667672_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	4.11107e-87
NC_018681.1\|WP_014981424.1\|665471_666938_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	9.83025e-67

>NC_018681.1|WP_011207082.1|670726_670969_+|MbtH-family-protein
MSTNPFDDEDGRFFVLVNDEEQHSLWPAFAEVPAGWRVVFGEDSRAACVEYVEKNWTDMRPKSLRDAMAADDAARQGAQS
>NC_018681.1|WP_014981428.1|669722_670556_+|alpha/beta-hydrolase
MPLATVNGISLNYQVKGDRARGTDVKGSGPLVVMIMGTGSPGRVWELHQVPALVAAGYRVCTFDNRGIAPSYEAADGMTIDQLVADTAGLIELLDEGPALVVGTSMGARVAQELALARPELVRKAVFMAGHGRLDQFQKTLSLGEHELDAGGVKLPAKYEAAVTAVMNLSPATMAEPNSARDWLDLFEFTGGPVPPGIRAQRRMDHDFERVQAYRAITVPCLSVGFADDRMIPPYLSREIAEVIPGARYQEVPDAGHFGYLEQPETVNKILLDFFAS
>NC_018681.1|WP_014981427.1|669385_669556_-|hypothetical-protein
MAAKGSANDIADDDLEPLADETARQAQRVVAAYAEDADECRMLLSMLGIGPSSRVE
>NC_018681.1|WP_141691826.1|667741_669202_-|trehalose-6-phosphate-synthase
MVVANRLPVDLERLPDGTSRWKRSPGGLVTALEPVLRNNKGAWVGWAGVPDADVDPIIEDGLELHPVPLSAEEVADYYEGFSNGTLWPLYHDVIVRPVYDRKWWAAYVTVNRRFAEATAKVAAEGATVWVQDYQLQLVPKMLRMLRPDLTIGFFLHIPFPPVELFMQMPWRTEIVEGLLGADLIGFHLPGGAQNFLYLARRLAGQPTSRGTIGVRSKLGVVQVGFRTVRVGAFPISISSAELDEHSRRRSIRERAAKIRAELGNPKTILLGVDRLDYTKGIDIRLNALEELLLEQRIDPAETVMVQLATPSRERVESYIQMRGDIERQVGRINGEFARVGYPVVHYLHRPIPRDELIAFFVAADVMLVTPLRDGMNLVAKEYVACHSGLNGALVLSEFTGAAAELRQAYLCNPHDLDSVKDAIVSAIEDDRDTKRRRMRSLRRQVLAHDVDRWARAFLEALAQDQVAGSALLSDDDVYPEERQPTR
>NC_018681.1|WP_041562379.1|666934_667672_-|response-regulator-transcription-factor
MSGAPAEQAPEARVLVVDDEPMIVELLAVSLRYQGFAVDTAADGAQALDKARTFRPQALIVDVMMPGMDGFGLLRRLRADGIDSPVLFLTARDEMQDKITGLTLGADDYVTKPFSLEEVVARLRVILRRAGHTAPQRDNSRLRFEDIELDDDTHEVWKAGEPVALSPTEFTLLRYFMVNAGTVLSKPRILDHVWRYDFGGEVGVVETYVSYLRKKVDTGSERLIHTLRGVGYVMRAPSRSRSAGK
>NC_018681.1|WP_014981424.1|665471_666938_-|HAMP-domain-containing-histidine-kinase
MSLGRIGRIRAKAAAALSAVPLRVTLMVVLVLTAGLGLLISGAVVTSGLEQSLTNRTDQQLREGVIEWSRRARMPPPPVLPPDPRHAPSQFYVHSTSTDGRTFFIKAFGVEGEPALPENLPRGPITVGSTAGGPVQWRALTLRAPDGTTTVALPLTQNNDTVHRLVVLQLVVGLTVLAALALVAYFVIRRSLRPLRRVESTAAAIARGDLYRRVPVRGTNTEVDSLSRSLNGMLAQIQQAFAKTEASEAAARHSEAKMRQFIADASHELRTPLTTIRGFAELYRQGATGEPDLFMDRIERESQRMGILVEDLLMLARLDAQRPLEQGVVDLLAVASDAVHGARALAAAADPAGPRRRIELEIQSGEGTLEIVGDETRLRQVLTNLLNNALTHTPPEAAVAVRLTPTADDIVLEVADTGPGLPPEEAEHVFERFYRTDGSRTRSSGGTGLGLSIVQALVTAHGGTVRVQSVEGIGTTFTVRLPRGLRPA
>NC_018681.1|WP_041562378.1|664999_665485_+|h-domain-protein
MTMRSKILLAGASVVAVAALIVLGVNGFRIWNDDRAEQARKDAVAAADRSVSAMFTYDYQTVDKELPKAADNLSPKFRDDYLKLITQAIAPGAKEKQLTVHATTQAAGIVSADKSEVVVLLFVNQVTTSKDSPQGTTTGSRVKATVQKDGDRWLVDQVTPV
>NC_018681.1|WP_014981422.1|664139_665003_+|hypothetical-protein
MTDSNGDQRRTRRRAVRSVGPPADESAAPGVTSIPAEPAKAGVPVRAASSGPGSDRVPTPDDAVVADAGTIDPGTAADAETGTAATVETADNKTADVETVELGKTTSTSAIEPDASPADTTESKSRRGVGRILAFAAAAVLVLALVVGAGLSVVKARSIDARDERRTEFVQTARQAALNLTTIRADSAKQDIDRILAVASGQFKSEFDGRVDPFLNVVQQAKIVSNGEVVEAALESDDVDSAQVLVAVKQTLTNAGQEGPQTRLYRFRITVSRGDAGLTASKVEFVG
>NC_018681.1|WP_014981421.1|662715_664143_+|MCE-family-protein
MTLTRFVRTQLAIFAILTVIGLVVMGGVYVKVPAMLGIGRYDVTVQLAATGGLYPTANVAYRGTNVGVVQDVRLTTTGVEAHLSIDSDYKVPADVNAWVRSVSAVGEQYVDLIPAERPVGGNLADGSVIPVGRTKLPQDVGTLLDQSDRLLSSVADTRLRQVIDEAFKAFNGAGPDLQRFIDSASLLVQEAQNNAEPTKKLLDQIGPLLDTQIQSDAAIRSWTSDLATVTDQLRAHDVSLRNVLHEGPSAMQRVNAQFESLRPTLPLLLNNLVSTGQVGVTYHAGLEQLLVVFPPLIAALRTVIRGPAEYGAMVDFGTVVNDPPACTTGFLPTDQWRSPSELDSLPSPRGLYCKVPQDSPIQVRGIRNTPCAEFPGRRAPTPELCRTGYVPEGNNPPFGPVQPVAPAAAPPAEVPAQTAPAAYGTGTPAAARSYDPSTGQYIGPDGRTYRQGDIGPSGSGTVPSSWQAMLEEQQR
>NC_018681.1|WP_014981420.1|661480_662719_+|MCE-family-protein
MMPRRMTTMVLGLAVLLGVSGCEWDGLNSLPMPGTEGTMDGAYQVRIQMPNVTTLTRNSPVRVDDVTVGTVSNIEVEGWHALVTVSLNPNVHLPANAVAKIGQTSLLGSNHIELAAPTDTAAQGQLKGGDVIPLDRAGAYPTTEQVLSSLSVVLNGGGISQLETITRELNSALTGRENDIRDLLPQLETLTTGLDKQRNDIIAAMSGLDRLGGQFAQQRDVVARAIERIHPALAVLADRSASITAAISALGDLSDVTDRIITTSGENLKANLRSLAPVLETLADTGMNLVEALKIVPTFPFPMKNLDKAIKGDYLNLFITVDLTGKRLDNNWLIGTPLGGRFGGVEGVVGGFAPDTATQAGNPATGPLLPPPPAGQPAPALPGLPPIPGLPAIPGLTVPLPGNTAPQGGPGR
>NC_018681.1|WP_014981430.1|671626_672052_-|HIT-family-protein
MASVFSAIIAGQLPGRFVWEDDEFVGFLTIAPVTTGHTLVVPRKEIDQWQDVDTETFARLTAVAQKIGQAVRQAWDAPRAGLLVAGLEVPHLHVHVFPAFTMGDFDISGADTDPSPESMDDAQIRIKQALRDLGYGANVPD
>NC_018681.1|WP_014981431.1|672082_672460_-|PH-domain-containing-protein
MGLIDGIMGNAGRIDPGRAQQEYAKLMGEGEQIYAAYLLVRDAILFTNRRLILVDKQGMTGRKVSYHSIPYRAITHFSVETAGTFDLDAELAIWISGNPDPLQKRFNRQVDIYEVQGILSHFVSV
>NC_018681.1|WP_014981432.1|672621_673935_+|phosphoribosylamine--glycine-ligase
MRVLVIGSGAREHALVLALRRDPAVTGIVAAPGNAGIAQHAQTRPVDPCSAEAVVALATDVAADLVVIGPEVPLVLGVADAVRAAGIACFGPSAAAARIEGSKAFAKDVMAAAEVRTAHSEIVDNPADLDAALDRFGPTWVVKDDGLAAGKGVVVTADRSAARDHGAELLEQGHPVLLESFLDGPEVSLFCLVDGETVVPLLPAQDHKRVGDGDTGPNTGGMGAYTPLPWLSPDAVTAIVEDVVKPVAAELVRRGSGFSGLLYAGLAMGVAGPAVVEFNCRFGDPETQAVLALLESPLGELLNATATGTLAEVEPPRWRDGSAITVVVAAENYPGRPRIGDVISGAGDGALDDTAAVLHAGTALREDGALISAGGRVLNVVGVGADLAEARTNAYARITAIKLPGSHYRTDIGLAAVEDRIAVPDRASANSGQTREA
>NC_018681.1|WP_141691809.1|673940_674942_-|M23-family-metallopeptidase
MVALMLENARRAGLDRVRGVGGIVVIPPDWRARMREKPVRGIRVLFDRVKLGELLRHRPDPRELWRRRAELPELWAQRRPDRDKLLALLRKHRVLLAGLAATAVFAAGDTAYTGTISDQLPDVDHVQRVAVAYPLQMQTTPPSVRRYLNAIANGERLREQAVVAAAARATLERAKAEAAAAAAGEYQPWMAGGTLPNPGAVLPGMGGFVMPARGVFTSGFGSRWGTFHNGIDIAGPIGTPIYAVANGTVIDAGPAEGFGLWVRIRHDDGSITVYGHMYDFFVSRGERVPAGMQIARMGNRGDSTGPHLHFEVIVGGQHVDPRQWLAVHGLNFG
>NC_018681.1|WP_086006214.1|675068_676232_+|pyridoxal-phosphate-dependent-aminotransferase
MSRESRRSTIPPFYVMDVWKAAAQRARTHGDVLVLAAGQPSTPAPAPVLRATRTAIESELLGYTETFGILPLREVIAAHHTVTYGYPVDPDDVVITTGSSGAFSLIFLAAFDPGDTVVVARPGYPAYRNTLTALGCRVVELDCGAETRFQPTVAMLEALPEPPAGLVVASPANPTGTMIAPAELAALARWCDEHGTLLISDEIYHGITYAGADTATSSAWETSRESVVIGSVSKYFSMTGWRLGWMLAPAGLRPALQRLASNLTVCPPAISQYAALHAFGAEAKAELDGHVRRYALNRQLLLDGLPKLGITDLAPADGAFYAYADIGHLTDDARAWCADVLDHTGVALAPGLDFDTVHGNRTVRFSFAGATADIEAALLRLGHYLAV
>NC_018681.1|WP_014981435.1|676360_676999_+|TetR-family-transcriptional-regulator
MITATTPKGERRRQALVAAAAELLLEGGFEAVRHRSVATRADLPLASTTYYFESLEDLIARAVEFSGNVELDAMRRRVGEVSHRRRGAEATVDLVLDLLVGTDGHDEGARGQLIARYERSVASARHPELREVQLRLRAQLDELLADVLRRSDRLVRPEQLRRLVAVVDGAVVAALTELDPEPRRMARGALLEVIDIVAPATPQQVDRFRTLD
>NC_018681.1|WP_014981436.1|677005_678427_+|adenylosuccinate-lyase
MTLVPNVLATRYASPELVRLWSPEHKIVLERRLWLEVLRAQSELGIDLPAGVLDDYERVLEQVDLASIAERERVTRHDVKARIEEFNALAGHEHVHKGMTSRDLTENVEQLQIRLSLEHVYAHGVAVAARLAERAAEYQTLVMAGRSHNVAAQATTLGKRFASAADELLIALTRVRELIERYPLRGIKGPMGTAQDMLDLLGGDPAKLSRLEQQVARHLGFANVLTSVGQVYPRSLDHDVLSALVQVGAGPSSFAHTIRLMAGHELVTEGFQPGQVGSSAMPHKMNTRSCERVNGLQVVLRGYASMAAELAGAQWNEGDVFCSVVRRVALPDAFFAIDGMMETFLTVLAEFGAYPAVIARELDRYLPFLATTRILMAAVRTGVGRETAHEVIKEHAVAVALAMREQGREPDLLDRLAADERLPLDRAALDTALADKSAFIGAAEAQVSDVIAAVQKLVDANPEAARYTPSPIL
>NC_018681.1|WP_141691810.1|678490_679084_+|hypothetical-protein
MAIHAFVDESIRRDRYILCAVLIRGEQLHRARALVRSFCLPGQRRWHFNDESEQRQRHIIAAMAQCVGVGVAIYEGRGREVSVRHSCMTELVTDLVEIKAARLVIESRENQDQRDRQSIATALRKASAELQYAHMPPHTEPCLWWADAAAWAFGAGGRWRLTIMPLVRLVFDVNKPPLQRETRMLVVRPGPGSTSSS
>NC_018681.1|WP_041562381.1|679341_679764_+|HIT-domain-containing-protein
MNPYTIFGDIVAGRAPASRVFEDDDVLAFMDIRPMTPGHVLVVPKVAARSLAELDPVVGGKLFQVGQRVAAALRVSEVGCDGVNFFLADGVTAGQEVFHVHLHVIPRTLGDGFGLRGRPTSPPRADLDYLAGSIRGALER
>NC_018681.1|WP_041562382.1|679892_680852_+|esterase-family-protein
MRRTSVAVSVLALALGLAVPTVVGSGTAAAAQIERIDRMTPTRAALFIDSPAMGRTIQVQVLHPAGGGARPTYYLLDGLDPGLTQSTWTNATDAEHFFAGSRVNVVLPVGGQASYYTDWQQDDPRFGHYRWETFLTEELPPLIDAAFNGNGVNAIGGLSMGGNAAFILAARKPWLYRAVAGYSACPDTGLAMGATMFSIANRGGNPVNMWGPPGSPAWAEHDPALLVENLRGKTIYLSSGTGLPGPHELEIKPQLAENIFLGGPVEVGVNTCVVAFEQRLRALGIPARVDYSPTGTHSWSYWQDTLHASWPTIAPAIGA

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Crispr_ID: NC_018681_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_018681_5

1168232-1168329

Orphan

Consensus_repeat	Method
CACGTGTGTGGCTGCGTAGCAAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_018681_5

>merge|NC_018681|5|1168232-1168329|CRISPRCasFinder
CACGTGTGTGGCTGCGTAGCAACGCCTTTCGCCGAGAGGGCGTAAATCCGGCGGTCTCGGTGACCGCCGCGCCCGCACGTGTGTGGCTGCGCAGCAAC

>NC_018681|5|4|1168232-1168329|CRISPRCasFinder
CACGTGTGTGGCTGCGTAGCAAC	GCCTTTCGCCGAGAGGGCGTAAATCCGGCGGTCTCGGTGACCGCCGCGCCCG
CACGTGTGTGGCTGCGCAGCAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_018681.1\|WP_014981806.1\|1161172_1161364_+\|PspC-domain-containing-protein	unknown	unknown	gnl\|CDD\|377200
NC_018681.1\|WP_014981807.1\|1161480_1161789_+\|hypothetical-protein	unknown	unknown	unknown
NC_018681.1\|WP_014981812.1\|1166124_1168008_+\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	unknown	unknown	gnl\|CDD\|234729
NC_018681.1\|WP_014981818.1\|1173594_1174674_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|366166
NC_018681.1\|WP_014981816.1\|1170804_1172253_+\|NAD(P)H-hydrate-dehydratase	unknown	unknown	gnl\|CDD\|238576
NC_018681.1\|WP_014981809.1\|1162344_1164048_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223021
NC_018681.1\|WP_014981819.1\|1174666_1175113_+\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-ATPase-subunit-type-1-TsaE	unknown	unknown	gnl\|CDD\|376771
NC_018681.1\|WP_014981811.1\|1165230_1166088_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223489
NC_018681.1\|WP_014981803.1\|1157090_1157606_+\|30S-ribosomal-protein-S9	unknown	unknown	gnl\|CDD\|178888
NC_018681.1\|WP_014981805.1\|1159211_1160876_-\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NC_018681.1\|WP_014981808.1\|1161969_1162284_+\|hypothetical-protein	unknown	unknown	unknown
NC_018681.1\|WP_014981810.1\|1164079_1164388_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274528
NC_018681.1\|WP_086006262.1\|1175854_1176349_+\|ribosomal-protein-S18-alanine-N-acetyltransferase	unknown	unknown	gnl\|CDD\|273701
NC_018681.1\|WP_014981813.1\|1168396_1169578_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|225371
NC_018681.1\|WP_014981820.1\|1175168_1175849_+\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-dimerization-subunit-type-1-TsaB	unknown	unknown	gnl\|CDD\|274750
NC_018681.1\|WP_014981822.1\|1176345_1177389_+\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD	unknown	unknown	gnl\|CDD\|236585
NC_018681.1\|WP_014981814.1\|1169716_1170208_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NC_018681.1\|WP_141691985.1\|1170297_1170729_-\|cupredoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|259988
NC_018681.1\|WP_014981804.1\|1157823_1159200_+\|phosphoglucosamine-mutase	unknown	unknown	gnl\|CDD\|237672
NC_018681.1\|WP_014981817.1\|1172488_1173598_+\|alanine-racemase	unknown	unknown	gnl\|CDD\|234600

Protein	Function_ID	Function_description	E-value
NC_018681.1\|WP_014981806.1\|1161172_1161364_+\|PspC-domain-containing-protein	gnl\|CDD\|377200	pfam04024, PspC, PspC domain. This family includes Phage shock protein C (PspC) that is thought to be a transcriptional regulator. The presumed domain is 60 amino acid residues in length.	6.12785e-25
NC_018681.1\|WP_014981812.1\|1166124_1168008_+\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	gnl\|CDD\|234729	PRK00331, PRK00331, isomerizing glutamine--fructose-6-phosphate transaminase.	0
NC_018681.1\|WP_014981818.1\|1173594_1174674_+\|alpha/beta-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	1.68729e-26
NC_018681.1\|WP_014981816.1\|1170804_1172253_+\|NAD(P)H-hydrate-dehydratase	gnl\|CDD\|238576	cd01171, YXKO-related, B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.	2.4606e-61
NC_018681.1\|WP_014981809.1\|1162344_1164048_+\|hypothetical-protein	gnl\|CDD\|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	6.5342e-12
NC_018681.1\|WP_014981819.1\|1174666_1175113_+\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-ATPase-subunit-type-1-TsaE	gnl\|CDD\|376771	pfam02367, TsaE, Threonylcarbamoyl adenosine biosynthesis protein TsaE. This family of proteins is involved in the synthesis of threonylcarbamoyl adenosine (t(6)A).	1.30793e-45
NC_018681.1\|WP_014981811.1\|1165230_1166088_-\|alpha/beta-hydrolase	gnl\|CDD\|223489	COG0412, COG0412, Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism].	2.05311e-05
NC_018681.1\|WP_014981803.1\|1157090_1157606_+\|30S-ribosomal-protein-S9	gnl\|CDD\|178888	PRK00132, rpsI, 30S ribosomal protein S9; Reviewed.	1.72374e-75
NC_018681.1\|WP_014981805.1\|1159211_1160876_-\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	4.26343e-142
NC_018681.1\|WP_014981810.1\|1164079_1164388_+\|hypothetical-protein	gnl\|CDD\|274528	TIGR03345, VI_ClpV1, type VI secretion ATPase, ClpV1 family. Members of this protein family are homologs of ClpB, an ATPase associated with chaperone-related functions. These ClpB homologs, designated ClpV1, are a key component of the bacterial pathogenicity-associated type VI secretion system. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis].	0.000608965
NC_018681.1\|WP_086006262.1\|1175854_1176349_+\|ribosomal-protein-S18-alanine-N-acetyltransferase	gnl\|CDD\|273701	TIGR01575, rimI, ribosomal-protein-alanine acetyltransferase. Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR\|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification].	4.1066e-41
NC_018681.1\|WP_014981813.1\|1168396_1169578_-\|MFS-transporter	gnl\|CDD\|225371	COG2814, AraJ, Arabinose efflux permease [Carbohydrate transport and metabolism].	8.22488e-96
NC_018681.1\|WP_014981820.1\|1175168_1175849_+\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-dimerization-subunit-type-1-TsaB	gnl\|CDD\|274750	TIGR03725, T6A_YeaZ, tRNA threonylcarbamoyl adenosine modification protein YeaZ. This family describes a protein family, YeaZ, now associated with the threonylcarbamoyl adenosine (t6A) tRNA modification. Members of this family may occur as fusions with ygjD (previously gcp) or the ribosomal protein N-acetyltransferase rimI, and is frequently encoded next to rimI. [Protein synthesis, tRNA and rRNA base modification].	2.50176e-50
NC_018681.1\|WP_014981822.1\|1176345_1177389_+\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD	gnl\|CDD\|236585	PRK09604, PRK09604, tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD.	9.31848e-170
NC_018681.1\|WP_014981814.1\|1169716_1170208_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	2.06919e-12
NC_018681.1\|WP_141691985.1\|1170297_1170729_-\|cupredoxin-domain-containing-protein	gnl\|CDD\|259988	cd13921, Amicyanin, Amicyanin is a type I blue copper protein that plays an essential role in electron transfer. In Paracoccus denitrificans bacteria, amicyanin acts as an intermediary of a three-member redox complex along with methylamine dehydrogenase (MADH) and cytochrome c-551i. The electron is transferred from the active site of MADH via the amicyanin copper ion to the cytochrome heme iron. The electron transfer from MADH to cytochrome c-551i does not involve a ternary complex but occurs via a ping-pong mechanism in which amicyanin uses the same interface for the reactions with MADH and cytochrome c-551i.	6.6946e-28
NC_018681.1\|WP_014981804.1\|1157823_1159200_+\|phosphoglucosamine-mutase	gnl\|CDD\|237672	PRK14318, glmM, phosphoglucosamine mutase; Provisional.	0
NC_018681.1\|WP_014981817.1\|1172488_1173598_+\|alanine-racemase	gnl\|CDD\|234600	PRK00053, alr, alanine racemase; Reviewed.	2.08168e-157

>NC_018681.1|WP_014981812.1|1166124_1168008_+|glutamine--fructose-6-phosphate-transaminase-(isomerizing)
MCGIVGYVGYRDALGVVVDALRRMEYRGYDSAGVAIVDGAGASAVERKAGKLANLEAELAEVGVARFAGTTGMGHTRWATHGAPTDRNAHPHRDHSGKVAVVHNGIIENFAPLRRELEDAGVELRSDTDTEVAVHLVAQAYAAGPTAGDFAASALAVLRRLEGAFTLVFTHADHPEMIVAARRSTPLVVGVGKGEMFIASDVTAFIEHTREAVELGQDQAVVITADTYTVTDFAGTDAVARTRPFTIDWDLAAAEKGGHDYFMLKEIEEQPAGVADTLIGHFSQDQDGAGRIVLDEQRLADQELRDFDKVFVVACGSSYHAGLLAKYAIEHWTRLPVEVELASEFRYRDPVLDRSTLVVAISQSGETADTLEAVRHAKEQKARVLAICNTNGAQIPRESDAVLYTRTGPEIGVASTKAFLAQVTANYLVGLALAQARGTKYPDEVAREFAELEAMPKLVERVLATGPQVRAIARELAHVQTVLFLGRHVGYPVALEGALKLKELAYMHAEGFAAGELKHGPIALIEDGLPVIVVMPSPKGRAVLHSKLLSNIREIQARGARTIVIAEEGDDTVRPFADDLIEIPSAPTLFQPLLSTVPLQIFAAEVAQARGYDVDKPRNLAKSVTVE
>NC_018681.1|WP_014981811.1|1165230_1166088_-|alpha/beta-hydrolase
MSASVKSLLSTLTSRGPHRVLRGNLAIAGQPGVVFTPESGLNLPAVAFGHGWLTGVAHYRTLLEHLASWGIVAAAPDTERGPIPSHLGLATDLLTTLDICTGVRLGDGSISVHPERLALVGHGMGAGAAVIAANQRQVAAVAALFPAPTAPAAEQLGADIDTPALILAGATDIASVSSNALPLAATWGGPMVLRAIDGASHNGIVEGRRVLAAVGAGKHESKTARTTRALLAGYLLAKLAGDKTYRVFADPDADIPHTAVIDPNAKEETPTPKLKVGQLASLLRR
>NC_018681.1|WP_014981810.1|1164079_1164388_+|hypothetical-protein
MNHAYEIECIVEENRRAVLRLQDEYDEMKQRLSDRGGPELLAAIQEAEAQAEEERARQETEAREQREAIARSIAARRANRDVAPVDAEDEEAAFYQRKTWLI
>NC_018681.1|WP_014981809.1|1162344_1164048_+|hypothetical-protein
MVDYQAGDSATVQQMLDNGAEGLMYFESYLPRYHTVHDKFGYGRGDLPEYSALCALFDAEREMDLDTLGQIAATVSKVNGEVGTELHKQQVQLAALPAVWQGVAGDAAHTMLAEQVRRAETDRGTAVAVASTLSAAVPGLRSVVRSKAETVARYWDKDKPDIDNTGRKAIDQFIYNAENYADYELGRDAKKWLQETFVPHVDGTVDNFLALCKKTDSDVRRIYGQLADALARLDTSQYPAPADAPAPAEQPKGTGTPGTPGTPGTPGTPGTPGTPGTPGTPGTPGTPGTPGTPGTPGTPGTPGTTPASTVPAETTPAATVPTTTKIPSLDGLASLSQVASSLSPLTSTLTSAVTSGLSSLTSSLATGVNDALENLQSSLEPTPVDRDNDGKPDQPAAEFDVAGKHLKFELGADGLKLTMSDADGKPQEFSLKLDEHGVPVLSVNEPKAEGEPVPSDEPASDKPKGEQPTGEQPTGEQPTPAAEAPQPKDPAAAPRSEEAAPAAPDQEAPAPKAPAAEENTGQPGLPSGVPSARREEDGEHKPKPMPGSQNPDAPFDSGAELAEAGPL
>NC_018681.1|WP_014981808.1|1161969_1162284_+|hypothetical-protein
MGSVTVDPAVLQQIGANLKSSAAIIGNKVTDARRQDFGAAQAGRSYSAEGTKVHDGLARFATWLQNWQGAVDKTGAQITTSATTYATVDDANVRKITAVGVQLA
>NC_018681.1|WP_014981807.1|1161480_1161789_+|hypothetical-protein
MITSGELPGLELPGIDASSSLDGLGAVELHHPTQDIDGDGTLDTITTTGEEAMQVWTDYDHDGLADHVTVVEKDGDYAAWEFHRHPDGTSEWVRTDHGKIGS
>NC_018681.1|WP_014981806.1|1161172_1161364_+|PspC-domain-containing-protein
MTAPTRRFTRSTHDKWIAGVCGGIAEYLGWNANVVRLLFVISCLLPGPQFIIYLVLWLLMPKK
>NC_018681.1|WP_014981805.1|1159211_1160876_-|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MSTTLHARGLSAGHGERVLFEDLDLTLAPGDVIGLVGVNGAGKSTLLRMLADRRTPTGSITVSPPDATIGYLAQEPERVSGETVRQFLGRRTGVTTAQLAMDEAAERLADGGDEAATTYSDALERWLALGGADLEQRADEVAADLGLTVSLANGLETPMTGLSGGQAARAGLASVLLSRFDILLLDEPTNDLDLDGLARLEQFVAGVRVPLVVISHDREFLARTVNRVVELDLAQQQVGSYDGGYEAYLAEREIARRHAREAYDEYADTKAGLEARAQMQRNWLEHGVRNARRKARDPKKVDSDKVGRKMRAESTEKQAAKARQTQRRIERLDVVEEPRKEWELRMTIAAAPRSGSVVATLSDATLTRGDFTLGPVTTQVDWADRIVLTGANGSGKSTLLALLLGKIEPDTGSATLGAGVEIGEVDQARGLFRGTASLADTFGAQMPDWPDAEVRTLLAKFGLRGAHTLRPCETLSPGERTRAALALLQARGVNLLVLDEPTNHLDLPAIEQLEQAVESFTGTLLLVTHDRRMLDTIQATRRWHMDSGKLTETT
>NC_018681.1|WP_014981804.1|1157823_1159200_+|phosphoglucosamine-mutase
MGRLFGTDGIRGLANESLSPELAMRVSGAAAQILSRGKQRPLAVVGRDSRASGEMLEAAVTAGLTATGVNVLQVGVLPTPAVAYLTGLYDACFGVMISASHNPMPDNGIKIFAAGGHKLDDAIEDRIEALITEDLVVRPTGASIGRVVNAVGARDHGPAVPDQYSLAGTHERYVEHLVAATAQDLSGLTVVLDCAHGAASEVGPAAFRAAGATVISINAEPDGLNINDGCGSTHLDSIQQAVREHGADLGLALDGDADRCLAVDAAGRIVDGDAILAVLALAMHEAGELAQQTLVGTVMSNLGLHIAMRAAGIALRTTAVGDRYVLEELRRGGYTLGGEQSGHVIFPQFGTTGDGILTGLKLMARMATTRRSLAELAAVLQTVPQVLVNVPVSDKSLVATAPEVREAVQEAERILGDTGRVLLRPSGTEELVRVMVEATDPAQARQLADDLAKRVASV
>NC_018681.1|WP_014981803.1|1157090_1157606_+|30S-ribosomal-protein-S9
MTAPEEFNEEAVAEEFDAVEVVEDGEGYDEAEVSAESFAPIVIDRPVQTVGRRKEAVVRVRMLPGSGNFVLNGRTIEDYFPNKVHQQLVKSPLVTVERTESFDIHARLVGGGPSGQAGALRLAIARALIEVTPDDRPALKRAGFLTRDPRATERKKYGLKKARKAPQYSKR
>NC_018681.1|WP_014981813.1|1168396_1169578_-|MFS-transporter
MPLALLALTLGAFGIGTTEFVVVGLLPDIADTYAVSIPTAGLLVTGYALGVVAGAPLMTGLGTRVSRKRMLLGMLLLLVAGNVLSAVAPTFGLMLTGRIVASLAHGAFFGIGAVVAGSVVRPDKRAGAIAIMFTGLTVATMVGVPVGTLLGQQFGWRLTFLIVALVGLIGLLGVALLVPEQPAPPDARLRTELAVFRNPQVLLAMAMTVLGFGGVFAAITYLAPMMTEVTGFADSSVTWLLVLFGLGFSAGNLIGGKFADRHLMPMLYLTLGGLAVALALFTLTAHNKVTAAITIVLIGALGFATVPPLQKRVLDQASGAPTLASAVNIGAFNLGNAVSAWLGGLVIAAGFGYTAPNWVGVALVVTALGLAVWSGALERRAATEPAPALVPAN
>NC_018681.1|WP_014981814.1|1169716_1170208_+|MarR-family-transcriptional-regulator
MTADAALTGLADGWYALSLLHDRIEAHIERALQSGHDLSVREYSLLVVLSRQHDGPGGHLRMNQVAEAVVLSQSATTRLVTRLEDRGLLQRYLCPDDRRGIYTDVTPPGLALLDRARPTHDDALAGALGQAAADPELAPLVAAVEALNTASARSPRTRAYRPV
>NC_018681.1|WP_141691985.1|1170297_1170729_-|cupredoxin-domain-containing-protein
MPMVTRRARSTQVATGVAVLTAVLVAGCGGGDSGPAATTTKRPAQPVTTTTQPAGDTKPAAVTIDVRDMKFAPGEVTVKVGDTVTWHFTDKAPHTVQGIGDKAMGLNSPIIDKGDWSYTFTAPGTYRYLCSLHPEMRGTVTVQ
>NC_018681.1|WP_014981816.1|1170804_1172253_+|NAD(P)H-hydrate-dehydratase
MSTQRGYFTADEVRAAEAELFTRVPDGVPMQRAAYGLATVVARELRARTGGVAGRAVTLLVGSGDNGGDALWAGSMLRRRGVEVTAVLLNPARAHAKGLAALRKVGGRVRAEIGGPDLVVDGIVGISGRGSLRPDAAELVAGLRVPIVAADLPSGVDPDTGAVTGPAVRADVTVAFGAYKPVHVLAAPYCGRTELVPIGLRLPGPNLAALTPGSIGADWPVPAATDDKYTQGVTGICAGSASYPGAAVLCTGAAVAATSGMVRYAGTGAAEVLAKFPEVIATQQVSEVGRVQSWVFGPGAGTDADARNRLVEILATELPVVVDADGLTMLAAEPGLVRARTAPTVLTPHAGEFARLTGRDIGPDRVGAVRSLADDLQVTVLLKGRATLVATPGAPVLVNEAGASWAATAGAGDVLSGVLGALLAAGRDPAWSAAAAARVHALAANLAAQEGHSAGAPISATPLLEHIRPAIGTLRAFADRVV
>NC_018681.1|WP_014981817.1|1172488_1173598_+|alanine-racemase
METVVDLDAIAHNVRILRELAGDAAVMAVVKADGYNHGAVEVGKAALAAGAAELGVTTIAEAVRLREAGITAPILSWLNNSAADYAAAIGADIEIGVSSLDHLRAVAAATEQTGRTATVSLKVDTGLNRNGLSPVEYPQALAELRTLVDAQAMRFRALFSHLANADEPAHPVNDMQRDRFLEAIAVAKEHGLEPELVHLANSPATLTRPDLAFDMVRPGIAMYGHSPVAEDFGLRPAMTFQARVALVKQVAAGEGVSYGHTWYAPRDTTVALIPVGYADGVFRPLSGRFEVWLGGARRPNVGRVCMDQFVVDLGDNAANVREGDMAVLFGGGPGEPRAQEWADLLGTIHYEVVCSPRGRSVRRYVGGGR
>NC_018681.1|WP_014981818.1|1173594_1174674_+|alpha/beta-hydrolase
MSRRRVTAVRGGLATAGVVAALAGAHALRRAGARVLWPARRDEYRDENFALIDEDRAGSVHTEDGVRLATRACGPADAPVTVIFVHGFCNTMESFHFQRRDLEKRWGARARLVLFDLRGHGRSGTSATERCTVSQLGRDLAAVITDAAPAGPVVLVGHSLGGMSVLAAAAQFPELFAERVRGIALLSTAAAEVTAAGITQLLRNPAIDGFRMAVAVAPALVQAGRTTARHVITPILHVSSFHGPVSPTLSRFTTMMIDDTPVETIVKFLKAIELHDESAALPALAQVPVLIIGGSHDLVIPFRNSRALARELKASELIHLREAAHMAHLQFPDIVNDALDRLLVRAGVLEPHPSEVTSG
>NC_018681.1|WP_014981819.1|1174666_1175113_+|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-ATPase-subunit-type-1-TsaE
MADRQQRTLPTVADTEALGRELAAGLGAGDLVVLDGPLGAGKTALTRGIAAGLGVQGRVSSPTFIIARQHRAGAQVGAVPLVHVDAYRLGGDLDELDALDLDTDLHQAVVVVEWGRGVVEHLTDRHLRVQLSREPDSDVRTAEWEWVD
>NC_018681.1|WP_014981820.1|1175168_1175849_+|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-dimerization-subunit-type-1-TsaB
MLVLSVDTATPAVTAGLVELEQAAPIQTRTVASRVRVDPRAHAEVLTPQILECLTEAGRSRTDLAAVVVGVGPGPFTGLRVGMATAAAFGDALGLPVYGVCSLDAIAADAAADLTPESELLVVTDARRREVYWARYRDGVRVAGPEVAKPGEVDLAQATVIAGSASHVDFFDLPVLPVETPSPAGLATVAAGAVLARAVPDPLVPLYLRRPDAVEKSYRTLDRTGA
>NC_018681.1|WP_086006262.1|1175854_1176349_+|ribosomal-protein-S18-alanine-N-acetyltransferase
MDIRIEPMAGTDIDRCVELEQLLFPEDDPWHAVAFQSELAAAHNRYITARDADGRMVGYAGIALLGDDRHPEAEVHTIGVDPSYLRAGIGTRLLEALLDEAGKRGGPVFLEVRTDNDPAIALYAKHGFHIIGLRKNYYHPSGADAYTMRRPALSALPLPDEVLS
>NC_018681.1|WP_014981822.1|1176345_1177389_+|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD
MIIMGIESSCDETGVGIVRRHADGSCELLADEVASSVDQHARFGGVVPEIASRAHLEAIVPAMRRALAAAGIAKPDALAVTIGPGLAGALLVGVAAAKAYAAAWDVPFYALNHLGGHVAVDTLEHGPMPPCVALLVSGGHTHLLHVTDLAEPIVELGSTVDDAAGEAFDKVARLLGLGFPGGPALDAAAAQGDPGAIAFPRGMTGPRDARYDFSFSGLKTAVARYVEAAQRSGLTAADLPIPNIAASFQEAVADVLTMKAVRAAQDVGVDTLVLGGGATANSRIRSMAEERCAAAGLTLRVPKPRLCTDNGVMIAALGAHVIAGGAPPSALTVATDPGLPVSVSRVP

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Crispr_ID: NC_018681_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_018681_6

2256777-2256878

Orphan

Consensus_repeat	Method
CTCGGAACCTCCAGCGCTCACCCGGCGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_018681_6

>merge|NC_018681|6|2256777-2256878|CRISPRCasFinder
CTCGGAACCTCCAGCGCTCACCCGGCGAGAACCTGCAGTGCTCATCCGGCGAGCGTGGCGGCGACCAGTTCCGCTCGGAACCTGCAGCGCTCACCCGGCGAG

>NC_018681|6|5|2256777-2256878|CRISPRCasFinder
CTCGGAACCTCCAGCGCTCACCCGGCGAG	AACCTGCAGTGCTCATCCGGCGAGCGTGGCGGCGACCAGTTCCG
CTCGGAACCTGCAGCGCTCACCCGGCGAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_018681.1\|WP_014982803.1\|2254360_2254564_-\|hypothetical-protein	unknown	unknown	unknown
NC_018681.1\|WP_014982800.1\|2251734_2252385_+\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|223943
NC_018681.1\|WP_014982811.1\|2263110_2263842_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NC_018681.1\|WP_029892685.1\|2262265_2263060_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|272861
NC_018681.1\|WP_141691958.1\|2249769_2250132_+\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132914
NC_018681.1\|WP_014982801.1\|2252395_2252956_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379883
NC_018681.1\|WP_014982816.1\|2269105_2269390_+\|DUF3761-domain-containing-protein	unknown	unknown	gnl\|CDD\|315295
NC_018681.1\|WP_041562530.1\|2260447_2261665_+\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035
NC_018681.1\|WP_041562528.1\|2254671_2255589_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293835
NC_018681.1\|WP_014982798.1\|2248798_2249686_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|235737
NC_018681.1\|WP_014982814.1\|2266923_2267814_+\|RNA-polymerase-sigma-70-factor	unknown	unknown	gnl\|CDD\|132002
NC_018681.1\|WP_014982797.1\|2248136_2248739_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_018681.1\|WP_014982809.1\|2261648_2262269_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380054
NC_018681.1\|WP_014982802.1\|2252988_2254374_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-GatCAB-subunit-A	unknown	unknown	gnl\|CDD\|223232
NC_018681.1\|WP_014982813.1\|2265703_2266879_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224172
NC_018681.1\|WP_014982807.1\|2260228_2260426_+\|ferredoxin	unknown	unknown	gnl\|CDD\|379145
NC_018681.1\|WP_014982812.1\|2263963_2265487_-\|multicopper-oxidase-domain-containing-protein	unknown	unknown	gnl\|CDD\|182808
NC_018681.1\|WP_014982815.1\|2267849_2268998_+\|low-temperature-requirement-protein-A	unknown	unknown	gnl\|CDD\|377704
NC_018681.1\|WP_041562529.1\|2255935_2256580_+\|DUF4097-family-beta-strand-repeat-protein	unknown	unknown	gnl\|CDD\|372574
NC_018681.1\|WP_014982799.1\|2250791_2251676_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379262

Protein	Function_ID	Function_description	E-value
NC_018681.1\|WP_014982800.1\|2251734_2252385_+\|HAD-family-hydrolase	gnl\|CDD\|223943	COG1011, COG1011, Predicted hydrolase (HAD superfamily) [General function prediction only].	2.16656e-25
NC_018681.1\|WP_041562530.1\|2260447_2261665_+\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	3.29077e-87
NC_018681.1\|WP_014982811.1\|2263110_2263842_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	3.54028e-77
NC_018681.1\|WP_014982816.1\|2269105_2269390_+\|DUF3761-domain-containing-protein	gnl\|CDD\|315295	pfam12587, DUF3761, Protein of unknown function (DUF3761). This family of proteins is found in bacteria. Proteins in this family are typically between 100 and 157 amino acids in length.	3.77313e-21
NC_018681.1\|WP_141691958.1\|2249769_2250132_+\|STAS-domain-containing-protein	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	3.01093e-10
NC_018681.1\|WP_014982801.1\|2252395_2252956_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|379883	pfam16859, TetR_C_11, Bacterial transcriptional repressor C-terminal. This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. Another target protein is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli.	6.0929e-19
NC_018681.1\|WP_029892685.1\|2262265_2263060_-\|ABC-transporter-permease	gnl\|CDD\|272861	TIGR00025, Mtu_efflux, ABC transporter efflux protein, DrrB family. The seed members for this model are a paralogous family of Mycobacterium tuberculosis. Nearly all proteins scoring above the noise cutoff are from high-GC Gram-positive organisms. The members of this paralogous family of efflux proteins are all found in operons with ATP-binding chain partners. They are related to a putative daunorubicin resistance efflux protein of Streptomyces peucetius. This model represents a branch of a larger superfamily that also includes NodJ, a part of the NodIJ pair of nodulation-triggering signal efflux proteins. The members of this branch may all act in antibiotic resistance.	3.56513e-41
NC_018681.1\|WP_041562528.1\|2254671_2255589_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293835	cd16277, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily.Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	1.50282e-107
NC_018681.1\|WP_014982798.1\|2248798_2249686_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|235737	PRK06197, PRK06197, short chain dehydrogenase; Provisional.	4.66614e-107
NC_018681.1\|WP_014982814.1\|2266923_2267814_+\|RNA-polymerase-sigma-70-factor	gnl\|CDD\|132002	TIGR02957, putative_sigma_factor, RNA polymerase sigma-70 factor, TIGR02957 family. This group of sigma factors are members of the sigma-70 family (TIGR02937). They and appear by homology, tree building and bidirectional best hits, to represent a conserved family. This family is found in a limited number of bacterial lineages. This family includes apparent paralogous expansion in Streptomyces coelicolor A3(2), and multiple copies in Mycobacterium smegmatis MC2, Streptomyces avermitilis MA-4680 and Nocardia farcinica IFM10152.	9.11753e-117
NC_018681.1\|WP_014982797.1\|2248136_2248739_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	8.88027e-08
NC_018681.1\|WP_014982809.1\|2261648_2262269_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|380054	pfam17920, TetR_C_16, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. This entry represents the C-terminal domain found in a number of different TetR transcription regulator proteins found in Actinobacteria. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain.	2.8341e-28
NC_018681.1\|WP_014982802.1\|2252988_2254374_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-GatCAB-subunit-A	gnl\|CDD\|223232	COG0154, GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis].	1.10328e-147
NC_018681.1\|WP_014982813.1\|2265703_2266879_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|224172	COG1252, Ndh, NADH dehydrogenase, FAD-containing subunit [Energy production and conversion].	1.19455e-74
NC_018681.1\|WP_014982807.1\|2260228_2260426_+\|ferredoxin	gnl\|CDD\|379145	pfam13370, Fer4_13, 4Fe-4S single cluster domain of Ferredoxin I. Fer4_13 is a ferredoxin I from sulfate-reducing bacteria. Chemical sequence analysis suggests that this characteristic [4Fe-4S] cluster sulfur environment is widely distributed among ferredoxins.	4.19245e-12
NC_018681.1\|WP_014982812.1\|2263963_2265487_-\|multicopper-oxidase-domain-containing-protein	gnl\|CDD\|182808	PRK10883, PRK10883, FtsI repressor; Provisional.	9.68263e-95
NC_018681.1\|WP_014982815.1\|2267849_2268998_+\|low-temperature-requirement-protein-A	gnl\|CDD\|377704	pfam06772, LtrA, Bacterial low temperature requirement A protein (LtrA). This family consists of several bacteria specific low temperature requirement A (LtrA) protein sequences which have been found to be essential for growth at low temperatures in Listeria monocytogenes.	4.60083e-70
NC_018681.1\|WP_041562529.1\|2255935_2256580_+\|DUF4097-family-beta-strand-repeat-protein	gnl\|CDD\|372574	pfam13349, DUF4097, Putative adhesin. This has a putative all-beta structure with a twenty-residue repeat with a highly conserved repeating GD, gly-asp, motif. It may form part of a bacterial adhesin.	0.00635053
NC_018681.1\|WP_014982799.1\|2250791_2251676_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	8.12057e-08

>NC_018681.1|WP_041562529.1|2255935_2256580_+|DUF4097-family-beta-strand-repeat-protein
MPTFTTPKPVALTVEVLSGDVTVIASDRVDSVVEVRPADATKKGDVLAAEQTKVAFAEGVLTVRTPKQWRTYTPFGGNPSIMVRVEVPTGSLLKASAAVGRLLVVGELRQSDLEISAGDITVERPGGAVTAKVAKGDVRVGDAARGVLRLETSMGELEVGIRPGSAARLEVDAKSGTVQNHLGAVHRPAADEDTVQVYARNTFGNVIIRHAVAA
>NC_018681.1|WP_041562528.1|2254671_2255589_+|MBL-fold-metallo-hydrolase
MQTTGTAGVSTAWPVGDLTIHRVDELALAAETGAWLLPSATPDLIAGQPWLQPAFADDQGILRFASHSFAVLVDGLRVLIDTGIGNGKTRANPAWHDLNTDYLARLADIGFAPEAVDLVLLTHLHADHVGWNTVAEQGNWVPTFPNARYLTARAEREFWASYDMDEARSQMFRDSVHPIEDAGLLDLIDVPASGSAITPSLRLIPTPGHTPGHLAVELRSGSAEAVITGDCMHHPVQLSHPEISSCVDIDPGQAEATRRALLSELADTETLLLGTHFPDPTAGYVRSHEGGYRLSPISDSQPIRY
>NC_018681.1|WP_014982803.1|2254360_2254564_-|hypothetical-protein
MTAELSRAPGTAEWAARVDFSLPVDRRAEVSATLDHILSVVGLLRELDFTDTVPATVFHAGGRDATV
>NC_018681.1|WP_014982802.1|2252988_2254374_-|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-GatCAB-subunit-A
MQPYELTLADASAAMQAGQLSPVELVDSILDRIEHVEPLLGAYVTVTTDRARTAARQAEREIAQQRTRGALHGIPVALKDLIDVAGLPTTASSRVRAGHRAETDSAVTTRLAAAGTALLGKTHTHEFAYGLTTPQTRNAWNLERVAGGSSGGSAVAVAASAATFALGTDTGGSIRVPAALNGVVGLKPTYGLVSRHGVTALSWSLDHVGPITRTVADATLALTALAGPDPRDPASLSHTADYRLDTDIDLRGLRIGVPVNYYFDRVEPGIETAVRAAIDHLSGLGAELVEIEIPMTRYIKAIQWGLMVPEASAVHENSLRSTPDRYGPDVRNLLEAGTFLPAADYLRAQRARTLLREAVIRLFNDVDLIAAPTVPATAARAGQDEFHWPDGTVETVADGYVRLSAPANITGIPAMTIPVGHDPAGLPIGMQLMTRPLGEPLLLRAGHAYERTTVRQPLPVL
>NC_018681.1|WP_014982801.1|2252395_2252956_-|TetR/AcrR-family-transcriptional-regulator
MSRRSIVRPGGRSARVQQSVHTAVRELEAEVGRAALTVPRIAARAGVTPSTIYRRWGDLQELLSDVAVERLRPDSPPEDHGDLRADLRAWTEQFIEEMDSPPGRAYLRDALLADPEGANAGQCSQFAADQIATILDRATRRGECPPALEPVLDQLVAPIMYRILLRPSAIDAEYARGLVSRVVDQC
>NC_018681.1|WP_014982800.1|2251734_2252385_+|HAD-family-hydrolase
MIGAVVFDVGETLVDETREYRTWADWLGVPRHTFVAVLGATIALGHDYRAAFQVFQPGFDLAREREARAQAGRPETYGEEDLYPDVRPALSKLRELGVWVGVVGNQTVRSGRILRSLDLPADFIATSDDWGVAKPSPEFFAKVVEVAPCTGEEIVYVGDRIDNDVAPAKAAGMRAAYIQRGPWGWIHRDKPEVARLSDWRIRDLTELPGIVAAENV
>NC_018681.1|WP_014982799.1|2250791_2251676_+|helix-turn-helix-domain-containing-protein
MTAEPAQIVVDPGVAERGPTALRIAVGGQLRKLREYRGITPQEAGDHIRGSYAKISRLELGRTGFKERDIVDLLDLYGVPDSEQREMFVDLARKANEPGWWHRYNDLLPQWFETYVGLEGAARVIRTYEGQLVPGLLQTENYAAAVVGMGEKTDEAARRVALRSDRQRILDAPGGPLLWAVLDEAVLHRPVGGAAVQREQIEHLVTMSAKPNVTIQVLSYRSGGSAAAGSSFTMLRFAELDLPDIIYLEQLTTALYLDRKEDVRLYRGVMDRLSVQAETPDRSRELMMDAAAAL
>NC_018681.1|WP_141691958.1|2249769_2250132_+|STAS-domain-containing-protein
MTTMVGSVYIEGMPFEISLDCYTDAVVVTGGGDVGLTSALSLVTALRRAVEMPRPLVIVDLSRVDHCGAVGLAALVLTTRNAAPRPVRIVPSPYIRRALRAGGLDRAVVLCADLTSARAT
>NC_018681.1|WP_014982798.1|2248798_2249686_-|SDR-family-NAD(P)-dependent-oxidoreductase
MADHKWTSTDLPSFAGRRVVVTGANSGLGLIVTRELARVGAHVVLAVRDVARGNEAARRIAGSTEVRALDLADLASVRRFAKEWTGDLDVLVNNAGIMLVPEGRTHDGFENQIGTNHLGHFALTNLLLPHLTDRVITVSSQAHRRGTVDLTDLNWETRKYSASGAYAQSKLANLLFTLELQRRLIAAGSRRAYSAHPGIAATNLQRHSGSLLTGALMHLGNRLLAQPAHTGALPILYAISQDLAPGSYVGRDGLFEYRGSPTLVGRSAEARDAEKALELWKLSEQLTHVKCPLPH
>NC_018681.1|WP_014982797.1|2248136_2248739_-|TetR/AcrR-family-transcriptional-regulator
MCADRPYHHGDLRNRLLERAELALREHGVEQLSLRQLARDAGVTHNAPSRHFADKQALLDALAVTGFQRLGAALDAVAGEAEPLPFEGRFRVLARAYLDFALENPALLSLMFARKHSPTGGTEMGAAVMTAFTLPVTLTADAQSRGEIIDGDPLRIGWTVAIALQGLASFVTAGLVGDDGVDALLNETVTNLIHGLHPRP
>NC_018681.1|WP_014982807.1|2260228_2260426_+|ferredoxin
MELRVDRERCIGAGMCVLTAPDMFDQADEDGRVLPLRRTPTPDQEQAVREAVEMCPSGAITFVAN
>NC_018681.1|WP_041562530.1|2260447_2261665_+|cytochrome-P450
MNTTVPVPHGLPMERNAGPFDPPREITQLRAARPVSPLIFPDGHEGWLVTGYDAVRQLMADTRFSSRQDIGIVHVPYETPGMPAATEPSPPMPGLFIAMDPPEHTRFRRKLIGAFTVRRMKMLEEHIIEITERQLDEMARLTPPVDLVKAFALPVPSLVICELLGVPYADRETFQVNSAKFLVKDQTLDEKMAAFGAMLGYLTGLVTQKRAAPGEDILSDLAQQEDLTIEELTGIAFLLLLAGHETTANMLALGTFALLEHPEQLAELRANLELVPDAVEELMRYLSVADIFYRYATEDIELGGETIRAGSTVVVSLLAANRDPLRFDRPDDLDLHRTSRGHLSFGHGVHQCLGQQLARIEMRAGFERLLRRFPTLELAVPAADVKLRTDMNIYGVHELPVTWTV
>NC_018681.1|WP_014982809.1|2261648_2262269_-|TetR-family-transcriptional-regulator
MNGSRGRPARSGRRPGQSGAREAILDAARARFAEAGFDKTSIRAVASDAGVDPALVHHYFGTKQELFGAVVQLPVNPEHTLGAVDAAPIDRLGETILRGVLAVWDSPAGAGVVAMVRSIIAGGDTSLARSFILEVVLERVRLRIATPDDDGRLRVALVGSQMIGLLMARKIVGIEPMASAPAEDLITAIAPTLQRYLTGEITTPSK
>NC_018681.1|WP_029892685.1|2262265_2263060_-|ABC-transporter-permease
MTRSTESATRRTPTLRPYLATTTRILRQLRNDHRTVAMIVVVPALLMTLLYFIYKDTPPSPFNPVSLFDRVGISMLGILPFIVMFLITAIAMQRERTSGTLERLLTTPLAKLDLLGGYGTAFSLAAAAQAGVACLVSFGLLGLDSAGNPGWVVLIAVVDAVCGVALGLLASAFARTEFQAVQFMPVVVAPQIFLCGLLVPRGELPGWLEAISNVLPMSYAVDALQEVSTHPNATGTMWRDLAVVAGFSVVALCLGAATLRRRTQ
>NC_018681.1|WP_014982811.1|2263110_2263842_-|ABC-transporter-ATP-binding-protein
MSQTHSSAAVDVRNLSVRRGGRRVLHDVSLTIPRGSITGLLGPSGCGKTTLMRSIVGTQIVESGEISALGLAAGSAALRHRIGYVTQAPSIYSDISVHENVAYFAALYGRERAAVDAAIQAVGLGEHARQRGDELSGGQKTRASLACALVAQPDLLVLDEPTVGLDPVLRVDLWKQFKELAAAGTTLVVSSHVMDEAEHCDRLLLMREGRLLAQLSPDELRAETGEQNLERAFLALITMGRAA
>NC_018681.1|WP_014982812.1|2263963_2265487_-|multicopper-oxidase-domain-containing-protein
MSSVFRPRRWRRFVLILGTLAVLFALTAGGAVTWVFVHATVSTVGSTEFRNELAVPPLVTGRLRADGTREFELDMRSGRTEFRAGHATETWGFNGTYLGPTLRARRGENVAVTVRNQLPEASTVHWHGMHLPAAMDGGPHQMVQAGAFWQPQWRIEQPAATLWYHPHPHGATEDHVRRGLAGLFLLDDEISETLPLPKNYGVDDLPVIVQDVKFRGAELDSSHAIFRDVGFLGDQTMVNGTMAPYRTVGDELVRLRLLNASTARTYTFGFADERAFALVATDGGLIERPLSLDRLPLSPGERAEIVVRMRAGERTILRSNELDAGLDFWTQRFAGGDDTFDVLELRAADTLRPSPELPAALAQPSTPDGSDSVVERRFELNLSGINGKPMAMDRIDFTVTRGTVETWTVRNNDGMPHNFHIHDVQFRVLRRNDGPPPAHLTGPKDTVFLPPNTTVQLALRFDGPADPTTPYMYHCHLLWHEDRGMMGQFAVVDPGGSAVPPPPHHGH
>NC_018681.1|WP_014982813.1|2265703_2266879_+|FAD-dependent-oxidoreductase
MDTAHRIVILGGGYTGMVAAARLARRTRKQDVRITLVNPSARFTERLRMHQIAAGQELADHRIADILAGTGVEFVQGWATSLDPASGHVLVDGTRTLPYDELIYALGSSTDTDIVPGAADHAWTLNDPRAAHRFAERLNVVAAQGGTVAVCGGGLTGIEAAAEIAENHPGLRVTLISSGAPGAMMSDKARAYLNRAFDRLGVVREIGRAVTKLLPDAVELAGGTVVPADLTLWTTGVRVAPLAAAAGIATDERGLIVVDETLRSVSHPNIHAVGDAAAIRMPWGQIHGTCQSGIPTAAYTADAIARELRGKAPKPFRFGYFHQPVSLGRRDAIIQFTRSDDTPGRFYLTGRAAVAYKESVSASPVPIVRFSRRMNVPVKLRAGRRADAPAV
>NC_018681.1|WP_014982814.1|2266923_2267814_+|RNA-polymerase-sigma-70-factor
MIDVMPEQDPFLEHRRLLFATAYRMLGTVTDAEDVLQDTWLKWHETDQATVRHPKAYLVRTVTNLSLNRLTSARATRENYVGPWLPEPLLTAPNVAEETELADTVSTAMLVILETLTPVERAVFVLREVFGYTHAEIADTLDRPEATIRQIAHRARGHVQSRRPRVDTDKAERDHITAQFMAACAGGDLNALMDLLAPDVTLWSDGGGIVTAARRPLHGPDHVARWILGVLAKPVSAGIELESAYVNGELGALACLDGNPGGAFTYDIVDGRIQNLRFQVNPTKLKGLYLDPDPLG
>NC_018681.1|WP_014982815.1|2267849_2268998_+|low-temperature-requirement-protein-A
MTNQSAELSADGGQVRASTLELFFDLVFVFTITQLTHVFTHHPGWPALGQVALVFGLIWWMYSGYVWLTNEVAPNSSARRTWLLIGMFSFFVLSLAIPDAFHGTGIAFGVGYVLVTAVHTALFASGGGASAALAIKHIGPFNAVAAALVLAGGFVHGWAQYLCWGVAFAVQIVSPYLIDTGDFVVRATHFCERHGLVIIVAIGESIVAIGAGLAGEKITPQLIVTVSLALCLAYVLWWAFFGFDDERGEHALAAVPDRERSRPALVAYGYALYPLLIGVILTAAGIQMSIGHGNESVGVATAAALSGGVALYFLAQFCFRSALRLPRPWMRLIAAAAVTATIPIGVVWVAWAQLAALVAVGYLAVIADDLITLRSGQHSSYV
>NC_018681.1|WP_014982816.1|2269105_2269390_+|DUF3761-domain-containing-protein
MPSKPLLGLFAAVVGLAALISAPASATPLLSAACPSGQYENVDNRCVPRPQQAATPPDGATARCKDGTYSFSQHRSGTCSGHKGVAEWLVNLPK

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Crispr_ID: NC_018681_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_018681_7

2527974-2528063

Orphan

Consensus_repeat	Method
CGGGAACCTGGAAGGGGTGCGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_018681_7

>merge|NC_018681|7|2527974-2528063|CRISPRCasFinder
CGGGAACCTGGAAGGGGTGCGGGTGCCTGTTCGTGCGGCGGGTGCGGCGGCGTGCGGTTGGGATGCCCGGGAGCCTGGAAGGGGTGCGGG

>NC_018681|7|6|2527974-2528063|CRISPRCasFinder
CGGGAACCTGGAAGGGGTGCGGG	TGCCTGTTCGTGCGGCGGGTGCGGCGGCGTGCGGTTGGGATGCC
CGGGAGCCTGGAAGGGGTGCGGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_018681.1\|WP_014983048.1\|2526088_2526736_+\|cysteine-hydrolase	unknown	unknown	gnl\|CDD\|376404
NC_018681.1\|WP_014983041.1\|2517322_2518171_-\|hypothetical-protein	unknown	unknown	unknown
NC_018681.1\|WP_141692066.1\|2516801_2517251_-\|hypothetical-protein	unknown	unknown	unknown
NC_018681.1\|WP_029893784.1\|2538271_2539006_+\|DUF4191-domain-containing-protein	unknown	unknown	gnl\|CDD\|379389
NC_018681.1\|WP_041562560.1\|2537644_2538094_+\|hypothetical-protein	unknown	unknown	unknown
NC_018681.1\|WP_014983055.1\|2534583_2535513_+\|DMT-family-transporter	unknown	unknown	unknown
NC_018681.1\|WP_014983051.1\|2530017_2530470_-\|6,7-dimethyl-8-ribityllumazine-synthase	unknown	unknown	gnl\|CDD\|237096
NC_018681.1\|WP_141692067.1\|2518199_2519060_-\|3-methyl-2-oxobutanoate-hydroxymethyltransferase	unknown	unknown	gnl\|CDD\|234723
NC_018681.1\|WP_014983047.1\|2525751_2526078_+\|hypothetical-protein	unknown	unknown	unknown
NC_018681.1\|WP_014983056.1\|2535570_2536671_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340842
NC_018681.1\|WP_041562558.1\|2519262_2520795_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|366166
NC_018681.1\|WP_014983053.1\|2531392_2532769_-\|M20/M25/M40-family-metallo-hydrolase	unknown	unknown	gnl\|CDD\|236208
NC_018681.1\|WP_014983045.1\|2522322_2525334_+\|bifunctional-[glutamine-synthetase]-adenylyltransferase/[glutamine-synthetase]-adenylyl-L-tyrosine-phosphorylase	unknown	unknown	gnl\|CDD\|237613
NC_018681.1\|WP_014983044.1\|2520894_2522235_+\|glutamine-synthetase	unknown	unknown	gnl\|CDD\|223252
NC_018681.1\|WP_014983052.1\|2530479_2531400_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|378820
NC_018681.1\|WP_063632244.1\|2526922_2527867_+\|endonuclease/exonuclease/phosphatase-family-protein	unknown	unknown	gnl\|CDD\|377028
NC_018681.1\|WP_014983046.1\|2525361_2525739_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
NC_018681.1\|WP_014983054.1\|2532765_2534436_-\|CocE/NonD-family-hydrolase	unknown	unknown	gnl\|CDD\|334820
NC_018681.1\|WP_141692068.1\|2536670_2537411_-\|DUF2334-domain-containing-protein	unknown	unknown	gnl\|CDD\|200603
NC_018681.1\|WP_014983050.1\|2528575_2530021_+\|metallopeptidase	unknown	unknown	gnl\|CDD\|225203

Protein	Function_ID	Function_description	E-value
NC_018681.1\|WP_014983048.1\|2526088_2526736_+\|cysteine-hydrolase	gnl\|CDD\|376404	pfam00857, Isochorismatase, Isochorismatase family. This family are hydrolase enzymes.	3.02391e-36
NC_018681.1\|WP_029893784.1\|2538271_2539006_+\|DUF4191-domain-containing-protein	gnl\|CDD\|379389	pfam13829, DUF4191, Domain of unknown function (DUF4191).	1.25564e-111
NC_018681.1\|WP_014983051.1\|2530017_2530470_-\|6,7-dimethyl-8-ribityllumazine-synthase	gnl\|CDD\|237096	PRK12419, PRK12419, 6,7-dimethyl-8-ribityllumazine synthase.	4.18852e-83
NC_018681.1\|WP_141692067.1\|2518199_2519060_-\|3-methyl-2-oxobutanoate-hydroxymethyltransferase	gnl\|CDD\|234723	PRK00311, panB, 3-methyl-2-oxobutanoate hydroxymethyltransferase; Reviewed.	9.31466e-166
NC_018681.1\|WP_014983056.1\|2535570_2536671_-\|glycosyltransferase	gnl\|CDD\|340842	cd03814, GT4-like, glycosyltransferase family 4 proteins. This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.	3.51811e-61
NC_018681.1\|WP_041562558.1\|2519262_2520795_+\|alpha/beta-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	1.81291e-21
NC_018681.1\|WP_014983053.1\|2531392_2532769_-\|M20/M25/M40-family-metallo-hydrolase	gnl\|CDD\|236208	PRK08262, PRK08262, M20 family peptidase.	0
NC_018681.1\|WP_014983045.1\|2522322_2525334_+\|bifunctional-[glutamine-synthetase]-adenylyltransferase/[glutamine-synthetase]-adenylyl-L-tyrosine-phosphorylase	gnl\|CDD\|237613	PRK14109, PRK14109, bifunctional [glutamine synthetase] adenylyltransferase/[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase.	0
NC_018681.1\|WP_014983044.1\|2520894_2522235_+\|glutamine-synthetase	gnl\|CDD\|223252	COG0174, GlnA, Glutamine synthetase [Amino acid transport and metabolism].	0
NC_018681.1\|WP_014983052.1\|2530479_2531400_-\|alpha/beta-hydrolase	gnl\|CDD\|378820	pfam12146, Hydrolase_4, Serine aminopeptidase, S33. This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.	1.35897e-84
NC_018681.1\|WP_063632244.1\|2526922_2527867_+\|endonuclease/exonuclease/phosphatase-family-protein	gnl\|CDD\|377028	pfam03372, Exo_endo_phos, Endonuclease/Exonuclease/phosphatase family. This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling. This family includes: AP endonuclease proteins EC:4.2.99.18, DNase I proteins EC:3.1.21.1, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56, Sphingomyelinase EC:3.1.4.12, and Nocturnin.	5.43975e-18
NC_018681.1\|WP_014983046.1\|2525361_2525739_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	5.16427e-40
NC_018681.1\|WP_014983054.1\|2532765_2534436_-\|CocE/NonD-family-hydrolase	gnl\|CDD\|334820	pfam02129, Peptidase_S15, X-Pro dipeptidyl-peptidase (S15 family).	2.50225e-49
NC_018681.1\|WP_141692068.1\|2536670_2537411_-\|DUF2334-domain-containing-protein	gnl\|CDD\|200603	cd11374, CE4_u10, Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily. The family corresponds to a group of uncharacterized bacterial proteins with high sequence similarity to the catalytic domain of the six-stranded barrel rhizobial NodB-like proteins, which remove N-linked or O-linked acetyl groups of cell wall polysaccharides and belong to the larger carbohydrate esterase 4 (CE4) superfamily.	1.20791e-54
NC_018681.1\|WP_014983050.1\|2528575_2530021_+\|metallopeptidase	gnl\|CDD\|225203	COG2321, COG2321, Predicted metalloprotease [General function prediction only].	2.64072e-14

>NC_018681.1|WP_063632244.1|2526922_2527867_+|endonuclease/exonuclease/phosphatase-family-protein
MRGWVKRGLLGAGWCAAAAGLAGVVLHLVAWQQKLLVLLASGATYLMVGAVIGLVCFVIAKGWRSAGVAAVLVGVVLWTAVPTFVPEGRAAAGPEVRVMQSNLLFGGADAGAVVRAVLDNRIDVLTVNELTNAAVDRLAAAGLDAALPHRYVEPTADGGGGTGIYSRYPLRDTKKYSGFILNQVSATMEHPDRGPVAVFAFHPIPPPLNFADWLAEMRRIREILDAEPGPAIVGADFNATRDHAAYRELLHGRFESAADQAGAGLLLTFPDDKQWGPIIGIDHVLLADAEAEEVRTLSIPRSDHRALIAHVRLT
>NC_018681.1|WP_014983048.1|2526088_2526736_+|cysteine-hydrolase
MREAFGLSIPQTVEDACDPRRMALLIYDMQVGIVSQLPDGDQIVRACVQLREAARANGFRVFYTRHMSLPIAASGVAQLRTAMQWQRVDDPAGLRAGFPQGSPQYQLVPELTPDDNEVVFDKVTMSAFAATPLDIALRDCGIDTFAIAGIALEVGIEPTIRHSLDLAYLPILVADACGAGHPAAAQRTHAALQFAGGTLVSDTAALTDFMSAPSR
>NC_018681.1|WP_014983047.1|2525751_2526078_+|hypothetical-protein
MKVIVFDRFKPGVTLETINPYLPEEVANVWRLWKAGIVRENYARADEPGVVIVFEVDSVEEAQQYVADFPLTKRGYLEWTYVPVQAPIPLEALMDADVDVAEPYDRTK
>NC_018681.1|WP_014983046.1|2525361_2525739_-|helix-turn-helix-transcriptional-regulator
MMPDKQYHCPVEVTVDLIGGKWKPVILAHLKEGVHRYGELRRLMPTTSEKMLVQQLRELEADGLVARTVFDTVPPQVEYDLTDEGRTLVPVLTALYTWGEQRAERTGLVLRSAANQFSDNTSRLP
>NC_018681.1|WP_014983045.1|2522322_2525334_+|bifunctional-[glutamine-synthetase]-adenylyltransferase/[glutamine-synthetase]-adenylyl-L-tyrosine-phosphorylase
MVRPPSARSAVPGVGRLGLLEPSAAATLRELGWDNVESIPVLWALSRAPDADLALNTLLKLYEQLGTDWAALDSAIRSETALRGRLFALIGASSAFADHLVADPAAWEILRRKALPAREEVLADLLDVVDAVPEEGDNAGPMLFRAGEHGPEVVALLRKRYRDQLMLLAALDLAATVENEPVLPYQVVGRHLTDLADAALTAALSVAVARVCKDGPVPVRLAVIAMGKSGARELNYVSDVDVVFVAEPADATATRLAAEMMSVASAAYFEVDAALRPEGKAGALVRTLDSHLAYYKRWARTWEFQALLKNRPMTGDLELGEQYRAALMPMVWNASERPDFVADVQAMRRRVEDLVPADLRERELKLGHGSLRDVEFAVQLLQLVHGRVDESLHVQGTVEALTALAAGGYVGRDDAANLTASYEFLRLLEHRLQLQRLRRTHTLPAADDEEGMRWLARAAHIRPDGRQDAVGVLGTEIRRNAVRVRRLHAKLFYRPLLESVVKMDPDALRLSPDAAIRQLAALGYQAPEHALGHLKALTGGVSRKGRIQALLLPTLLEWLGETPNPDAGLLAYRRVSEGLDDQIWFLRELRDEGAIAQRLMIVLGSSEYLPDLLINAPDTIRMYADGPGGPLLLSPQPEDVARGIMTAASRYDDPKRAVAAARSLRRHELARIASADLLGMLDVQQVCRALSSVWVAVLEAALAAVIRAGEAELGTPAPADFAVIGMGRLGGMELGYGSDADVLFVCDPRPGEDETKAVKWAIGIADKVQRLLGAPSTDPPLHVDAGLRPEGRNGALVRTLAAYAAYYQQWAQPWEVQALLRAHQVAGDQQLGLRFLHIIDKVRYPEGGVSTEAVREIRRIKARVDAERLPRGANPATHTKLGRGGLADIEWTVQLMQLRYAHDVLGLHNTSTLESLDVIEQTKLLDTADVELLRDAWLTATKARNALVLVRGKPTDQLPGPGRLLSAVARVAGWPNDDGSEFLDHYMRITRRAKAVVERVFGQ
>NC_018681.1|WP_014983044.1|2520894_2522235_+|glutamine-synthetase
MDRQKEFVLRTLEERDIRFVRLWFTDVLGYLKSVAIAPAELEGAFEEGIGFDGSAVEGFARVSEADMVARPDPSTFQVLPWSTSKGHQHSARMFCDITMPDGSPSWADPRHVLRRQLNKAGDVGFSCYVHPEIEFFLLENGPQDGSQPIPADSGGFFDQAVHDSAPNFRRHAIDALESMGISVEFSHHEGAPGQQEIDLRYADALSMADNVMTFRYLIKEVAIDEGVRATFMPKPFAQYPGSAMHTHMSLFEGEANAFHDPDDPINLSVTARAFIAGILEHAPEISAISNQWVNSYKRLIHGGEAPTAASWGRSNRSALVRVPMYTPNKSSSRRIEIRSPDSACNPYLTFAVLLAAGLRGIEKGYTLPPEAEDDVWSLTAAERRAMGFRELPGTLDEALQAMERSELVAETLGEHVFDFFLRNKRREWADYRSQVTPYELKEYLGL
>NC_018681.1|WP_041562558.1|2519262_2520795_+|alpha/beta-hydrolase
MALVRSGRGALIVAVLGLVAAGCTTAGHPTGPMPDVPAELGKFYHQTVQWGGCAGFGSPEDRFAPSAECAKITVPIDYAAPDGATAQIAVSRIKASGKKIGSLLMNPGGPGESGLTMSGLGNRTPLAQRFDRVGFDPRGVGSSTPSIVCETAQEQDAERAEAQKDNTPQGIAAAEDENRQYADRCTARTGKEFLAHVGTREVVQDLDVLRAALGDPKLSYLGYSYGTKIGSAYAEKFPDRVRALVLDGAIDSSQDPVQESLRQAAGFQKVFDAYAADCVSKADCPLGTDKAQAVPRFRALVDPLWDKSAPTTDPRGLSYGDALTGVRQALYTTDLWSVLTLGLSELRDGRGDTLLQLADLYDGRRDDGTYSNTTDAFNAIRCVDDPRISDRGVTGKQDIEYRKAAPFLDDGRGTGAAPLDQCTVWPVPNTSEPHRITVTGLPKTVVVSTTEDPATPYQAGVDLASQLGASLLTYQGSRHTIALSGGSSCVDQAVIDYLVDLKDPAPGLTC
>NC_018681.1|WP_141692067.1|2518199_2519060_-|3-methyl-2-oxobutanoate-hydroxymethyltransferase
MMSVSDSETPAYGAAPSQPKKAVRKTRVHHLQQMKADGERWSMLTAYDYSSARLFEEAGIPVLLVGDSAANVVYGYDTTVPITVEELLPLVRGVVRGAPHALVVADLPFGTYESSPQQALATATRFMKEGQAHAVKFEGGERVAEQIALITSAGIPVMAHIGFTPQSVNTLGGFRVQGRGDGAEQLIADAIAVQEAGAFAVVMEMVPAELAAQVTGKLTIPTVGIGAGADTDAQVLVWQDMAGYTSGKTAKFVKRFGDIGDQLRTAAANYADEVRRGTFPGPEHSF
>NC_018681.1|WP_014983041.1|2517322_2518171_-|hypothetical-protein
MTGRVVQAPAALLGQSIEPLTDWAFGVLAEHGLTVTGAPVETRRRAWSLVVRIPTSAGPMWAKANARAFAHEGHLLELLARLCPGSALEPVAVQPDRGWLLSRHGGDVAPDTAAEWTGLVRAYADLQQSLTTHIDELRATGTPYLPPARLVTVYQHYEPRIPGLGDRIAETAAELGDYNRLSIEHNDVHPGNAFAGTGLLFDWADAVITHPFLSHKILRTPHRAEYFARWRRGGPISRTEITLAERLAPLIALHPWRTIDVSAPPFARTVDALLDELRTSFR
>NC_018681.1|WP_141692066.1|2516801_2517251_-|hypothetical-protein
MMRSRWISRSTLLLAGVFAAAALTACGTESNPAPTGSSGSTTGSATATSKPSSTAPKPGTPEISDAAASQLCDMIRPELSNWRVQGPTLGRIGLNAMVHEWALRNGGINGAVLADKPVIDRITTKNCADVHKQAIEALELTDLASGLAF
>NC_018681.1|WP_014983050.1|2528575_2530021_+|metallopeptidase
MGKQRWRNGAVVVLALFGMVCAGCGVTVQDPAAPEAPATETDWGIAGSMTATGPSGPRPGVPDAPLTATNGDGGRLDTLALNSLADLQEFWTTEYHKDFPGPFTPVQSFFSWSAPAPKDQVIRFCDESTYHVVNAAYCGLDHTIGWDRGVLLPQVVEKFGEMAVVMVLAHEYGHAIQGQARLAGVRTPTLVLEQQADCLAGVFLRHVAEGNSAHFTVNTTDGLNAVLGATVAFRDQGFGDPGNAHGSAFERVTAVQIGYSDGTKGCKALTPKEIAQRRGQLPVSFGVADALFQLPVNRQSLERLSRTLLALFPAAEPPRFDYAGAGGDCANITVTEPVSYCPTANRIGTDVPALTKLGASARGQEELLSAMVQGDYSAFVLFVSRYTLAVQRERGLSLTGAETAGLRTACLSGVVSTKLSEPGGDVRLSADDLDEAVSELLTAGLAASDVNGKVVPSGYQRVEAFRTGVLDGEAACLSRYR
>NC_018681.1|WP_014983051.1|2530017_2530470_-|6,7-dimethyl-8-ribityllumazine-synthase
MGTTGSIAFLRAGWHSSIVGKAYEGFTAEYAELGYDPATVDVFEVPGAFEIPLHAQRLARSGKYAAVVAAALVVDGGIYRHDFVASAVIDGLMRVQLDTDVPVFSVVLTPHHFHEHSEHVTYFTEHFVTKGAQAARALASTLTSLRSLPV
>NC_018681.1|WP_014983052.1|2530479_2531400_-|alpha/beta-hydrolase
MHERAQQDRAEHRRGAVVTAEPEGEDAGIRIETGQFDGTGSGIAWRAWLPEAPARGVIVLVHGVAEHSGRYTHVGRRFAGAGFAVYALDHIGHGKSAGSKANIGSMDGAADNVAAMLDIASREYPDVPRFLIGHSMGSLIVLHLATRAPVDVAGIVLSAPPLVIPLGNPLQRLVAPLLTRLAPNLGVLKLDSSQISRDPAVVRAYDNDPLVYRGSLPARTAVEILDTTTLVKQRLGRLTVPLLVLHGTGDAIAAPAGTDLIERGAGSKDLTAIRYDGLYHEIFNEPEQDEVLGNVVDWLEAHVTGK
>NC_018681.1|WP_014983053.1|2531392_2532769_-|M20/M25/M40-family-metallo-hydrolase
MTEPVDDRTAERLAAALRCVTVSTDDPDDIDDAAFDRLSAHLEQSFPRVHAELELTRFGHSRLYRWAGVEPDQVEAILLAHQDVVPVDDPQRWTHPPFAGVVDGEFIWGRGAIDDKSRLLAILEAVEAALTAGIRPRHTIFLAFGHDEEVFGDTGAMHMAQHLRAQGVFANLLLDEGGMITTGVADRIEPPVATIMVGEKGYATVRFSVTELGGHSSMPGRQTAVGRIARAVGRIQDHPMPLRMTPVTADMLARVRKVMPAPRRQLLRLADLVAPLVTRVMAGRPQTEALVRTTTAPTVIRGGVKSNVLPQHAEAFVNFRILPGDTVASVLAHCRKVVRDNGVRIETAGVSSEPTVNAAPGAAFDLIAEIAQAIVPGTVITTGIVPGATDSRHYHDLAATRCNFAPIVLEERDLASIHGTDERLSRVNYARLIEFNRRLITELAYSTSSDPHPSGADA
>NC_018681.1|WP_014983054.1|2532765_2534436_-|CocE/NonD-family-hydrolase
MVSERRVLLRALCGLLLLLAPAIPVTAAAEPLGVPFQWKQAFIDAPDGTRLHADILRPDGLADDVRTPVILTVSPYRAHLAYLSEPRLTGGPSTENLQADMFLRAGYTYVIVDLRGFGGSSGCPDFGGPGERSDVATAVEWSANQPWSTGKVGMFGTSYEGWTGLMGLATKPKGLAAVASFEPVVDPYSYLYMQGVSWKFSGKPVTESGVRPADFAGLEHLLIASTPGRPEDSPEYQAAAAQLPMQCYQQYLAETGNHDGDSAFWRDRDLVVPLRGNTIPLFLGQGFVDYNTRAYRVFDLWNGLGPGAHRAWFGQWGHRTCHEKCGTPHFDTELLAFFDKHVAGRDVEIPGPRITVGQFDGRWRAETAWPPADAARVPVELRPGSYTDRGLVPGPDRELWSVSEPLTQAQHLSGIPTATLQLDGPATATVAVELYDIAPDNLATVITRGIAPVGDGTAEVRLLGQDWPIPAGHRIGVRVTDVVDDVWSHTPALASVTVTKARVELPMLTGARTADLPGGLTEGIVKWRNEKTIPLGPGVLNNATVSMNLPNRSGDR
>NC_018681.1|WP_014983055.1|2534583_2535513_+|DMT-family-transporter
MADGVEAVGAAPIDAAAVGTITLALVAALLFAVSAALQQGAAREAATADPQGRFLVIAGIARRLLTDRRWLAGQGANVAGFVVHAVALRLGAIAVVQSLLVVQLLFALPFAAARRRRPLLRRDWAGTVFVCAGLILLVGQSAAGHTELRPGLLPMAGAGVFLVIVTLIALSRLTRATQVRSALVAVAAGCCFATTAVLVVIATTALPDLSWALLGIPISTGLGGLLTQEAYARGSLPTALTAMTITDPVLSYTAGVTLFAAVHPQAVPLLLAAVLVITGITLLANSPTLHDERDRVAEGSAKQAVPESV
>NC_018681.1|WP_014983056.1|2535570_2536671_-|glycosyltransferase
MRIVQIANFYTPASGGLRTCLDEIGRGYLATGHERVLVVPGPADGDEATTSGRRITVRSPKFGAGGYHVLTARRTRPILDLLRPDVLECSDKLSVRWLAPWARGAGVPLVLFSHERIDAILRTRVPPGFPLATAADLANRRLCVRAEKVVVTSSFATAEFARIGATNVRRVPLGVDLTTFRPAAETSCATGESVRLVLVSRLSKEKCAERAIEAVRVLVDSGLRCELAVLGDGPLRHRLERLAAGLPVIFHGHLTDRVAMASLVADADIAIFPSPAETFGLAVLESLACGTPVVVPDEGAAGELVDAVGSGIVSDGSPHGLAAGVRALLTVPAPQRRRAARRAAERFPWSATVAGMLALYADYEAA
>NC_018681.1|WP_141692068.1|2536670_2537411_-|DUF2334-domain-containing-protein
MCARLVVSVHDVAPASAAETARWCADADGFGIPVSLLVIPGPWRGASLARQPEYAGFLRERRARGDEIMVHGWSHRAGPEGGWPRRTLGRAVARGAAEFAALDQSQAAAKLRDALAVMAESGLSTTGFTPPGWLASPAAEQALRAAGFTHTTDHFGAKDLRTGRRQRGFALSHRPGGGWSERFGAAMLQTFAQRNARNGGLVRLALHPDDLHHPGLRAATLRAIDAALTAGARPTTYAALIEAAAS
>NC_018681.1|WP_041562560.1|2537644_2538094_+|hypothetical-protein
MNEPVTADWEQFVQALAQCLSELPSRATLIIAAPGNRYVQFMQYDIKLSAELAGNHYLAQPIPDAAAAELRELGWNEPMLRREVDNWTKTMFWPISPGNLVEFARSVAIGFRDALGVATPVELRAMGWTEASGDLDLTVLGSMARRGWN
>NC_018681.1|WP_029893784.1|2538271_2539006_+|DUF4191-domain-containing-protein
MAAGKPTKEAKAAAKAARKQQSKERRQQLWQAFQMQRKEDKLLLPLMIGALLGITAIFLVIGLIFGLTWLLVPFGVVLGALAAFIIFGRRVQKSVYGKAEGQAGAAAWVLDNLQGKWRVTNGIAATTQLDAVHRVIGLPGVVLVAEGSPQRVKSLLAQEKKRTARLIGDTPIYDVVIGNDEGQVPLKELQRYLTKLPRNIDTKRMDLIEGRLSALSSRTGPAMPKGPMPAGAKMRGVQRTIRRR

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Crispr_ID: NC_018681_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_018681_8

3832198-3832323

Orphan

Consensus_repeat	Method
GTTGGGGCTTTGGAGGTGCGCGCTGCCCGTCGAGGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_018681_8

>merge|NC_018681|8|3832198-3832323|CRISPRCasFinder
GTTGGGGCTTTGGAGGTGCGCGCTGCCCGTCGAGGTGCAGCCTGTCCCGTGTGTGCGCGTCGTGGTGAGTGTCCCGGGTCCGGTTGTGCGGTTGGGGCTTTGGAGGTGCGCGCTACCCGTCGAGGT

>NC_018681|8|7|3832198-3832323|CRISPRCasFinder
GTTGGGGCTTTGGAGGTGCGCGCTGCCCGTCGAGGT	GCAGCCTGTCCCGTGTGTGCGCGTCGTGGTGAGTGTCCCGGGTCCGGTTGTGCG
GTTGGGGCTTTGGAGGTGCGCGCTACCCGTCGAGGT

Protein	Signature genes	Signature genes Name	Protein_function
NC_018681.1\|WP_141692036.1\|3837040_3837760_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227766
NC_018681.1\|WP_014984234.1\|3828412_3829204_-\|thioredoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|372611
NC_018681.1\|WP_014984242.1\|3835605_3836097_-\|glycosyl-transferase	unknown	unknown	unknown
NC_018681.1\|WP_014984247.1\|3839782_3840604_-\|SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|252734
NC_018681.1\|WP_042255506.1\|3827536_3827950_+\|roadblock/LC7-domain-containing-protein	unknown	unknown	gnl\|CDD\|224929
NC_018681.1\|WP_041562669.1\|3827062_3827446_+\|hypothetical-protein	unknown	unknown	unknown
NC_018681.1\|WP_041563941.1\|3841101_3841380_+\|hypothetical-protein	unknown	unknown	unknown
NC_018681.1\|WP_014984243.1\|3836130_3837030_-\|class-A-beta-lactamase	unknown	unknown	gnl\|CDD\|185339
NC_018681.1\|WP_014984240.1\|3833757_3834216_-\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|176867
NC_018681.1\|WP_014984239.1\|3833187_3833718_-\|O-acetyl-ADP-ribose-deacetylase	unknown	unknown	gnl\|CDD\|234759
NC_018681.1\|WP_014984233.1\|3827961_3828333_+\|hypothetical-protein	unknown	unknown	unknown
NC_018681.1\|WP_014984237.1\|3830858_3831335_-\|hypothetical-protein	unknown	unknown	unknown
NC_018681.1\|WP_029892383.1\|3837876_3838578_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227766
NC_018681.1\|WP_171904484.1\|3834717_3835554_-\|TipAS-antibiotic-recognition-domain-containing-protein	unknown	unknown	gnl\|CDD\|133381
NC_018681.1\|WP_081594021.1\|3825781_3826678_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|260108
NC_018681.1\|WP_014984238.1\|3831755_3831965_-\|hypothetical-protein	unknown	unknown	unknown
NC_018681.1\|WP_041562670.1\|3829370_3829769_+\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|240046
NC_018681.1\|WP_014984229.1\|3825480_3825681_-\|hypothetical-protein	unknown	unknown	unknown
NC_018681.1\|WP_014984246.1\|3838732_3839752_+\|NADP-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|225041
NC_018681.1\|WP_014984236.1\|3830119_3830839_+\|haloacid-dehalogenase-type-II	unknown	unknown	gnl\|CDD\|319787

Protein	Function_ID	Function_description	E-value
NC_018681.1\|WP_141692036.1\|3837040_3837760_-\|hypothetical-protein	gnl\|CDD\|227766	COG5479, COG5479, Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane].	1.87377e-24
NC_018681.1\|WP_014984234.1\|3828412_3829204_-\|thioredoxin-domain-containing-protein	gnl\|CDD\|372611	pfam13462, Thioredoxin_4, Thioredoxin.	3.55197e-19
NC_018681.1\|WP_014984247.1\|3839782_3840604_-\|SAM-dependent-methyltransferase	gnl\|CDD\|252734	pfam04672, Methyltransf_19, S-adenosyl methyltransferase. This family contains a SAM (S-adenosyl methyltransferase) domain, with a central beta sheet with 3 alpha-helices on both sides. Crystal packing analysis of the structure Structure 3giw suggests that a monomer is the solution state oligomeric form. An unidentified ligand (UNL, cyan) was found at the putative active site surrounded by the residues His57, His170, Phe171, Tyr216 and Met22. The UNL is likely to be a phenylalanine or phenylalanine-like molecule. (details derived from TOPSAN).	2.52749e-116
NC_018681.1\|WP_042255506.1\|3827536_3827950_+\|roadblock/LC7-domain-containing-protein	gnl\|CDD\|224929	COG2018, COG2018, Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only].	8.17826e-18
NC_018681.1\|WP_014984243.1\|3836130_3837030_-\|class-A-beta-lactamase	gnl\|CDD\|185339	PRK15442, PRK15442, beta-lactamase TEM; Provisional.	7.01748e-56
NC_018681.1\|WP_014984239.1\|3833187_3833718_-\|O-acetyl-ADP-ribose-deacetylase	gnl\|CDD\|234759	PRK00431, PRK00431, ADP-ribose-binding protein.	7.35518e-82
NC_018681.1\|WP_014984240.1\|3833757_3834216_-\|SRPBCC-family-protein	gnl\|CDD\|176867	cd07825, SRPBCC_7, Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins. Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	1.1342e-59
NC_018681.1\|WP_029892383.1\|3837876_3838578_-\|hypothetical-protein	gnl\|CDD\|227766	COG5479, COG5479, Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane].	2.69796e-24
NC_018681.1\|WP_171904484.1\|3834717_3835554_-\|TipAS-antibiotic-recognition-domain-containing-protein	gnl\|CDD\|133381	cd01106, HTH_TipAL-Mta, Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA. Helix-turn-helix (HTH) TipAL, Mta, and SkgA transcription regulators, and related proteins, N-terminal domain. TipAL regulates resistance to and activation by numerous cyclic thiopeptide antibiotics, such as thiostrepton. Mta is a global transcriptional regulator; the N-terminal DNA-binding domain of Mta interacts directly with the promoters of mta, bmr, blt, and ydfK, and induces transcription of these multidrug-efflux transport genes. SkgA has been shown to control stationary-phase expression of catalase-peroxidase in Caulobacter crescentus. These proteins are comprised of distinct domains that harbor an N-terminal active (DNA-binding) site and a regulatory (effector-binding) site. The conserved N-terminal domain of these transcription regulators contains winged HTH motifs that mediate DNA binding. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. Unique to this family, is a TipAL-like, lineage specific Bacilli subgroup, which has five conserved cysteines in the C-terminus of the protein.	3.99498e-41
NC_018681.1\|WP_081594021.1\|3825781_3826678_-\|hypothetical-protein	gnl\|CDD\|260108	cd13931, PT-CloQ_NphB, Aromatic Prenyltransferases (PTases) of the CloQ/NphB family. Members of the CloQ/NphB family of ABBA prenyltransferases catalyze the prenylation of phenols, naphthalenes, and phenazines. This family of fungal and bacterial proteins includes dihydrophenazine-1-carboxylate dimethylallyltransferase PpzP, the aromatic prenyltransferase from the clorobiocin biosynthetic pathway CloQ, and related proteins. CloQ catalyzes the attachment of a dimethylallyl moiety to 4-hydroxyphenylpyruvate, part of the biosynthetic pathway of the Streptomyces roseochromogenes antibiotic clorobiocin. PpzP, as well as EpzP, are important for the biosynthesis of endophenazines; they catalyze the prenylation of 5,10-dihydrophenazine-1-carboxylic acid (dhPCA). Streptomyces NphB catalyzes the addition of a 10-carbon geranyl group to small organic aromatic substrates and is involved in the biosynthesis of the antioxidant naphterpin. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto aromatic substrates in biosynthetic pathways of microbial secondary metabolites.	3.00504e-102
NC_018681.1\|WP_041562670.1\|3829370_3829769_+\|NUDIX-domain-containing-protein	gnl\|CDD\|240046	cd04690, Nudix_Hydrolase_31, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	1.19682e-41
NC_018681.1\|WP_014984246.1\|3838732_3839752_+\|NADP-dependent-oxidoreductase	gnl\|CDD\|225041	COG2130, COG2130, Putative NADP-dependent oxidoreductases [General function prediction only].	2.87948e-175
NC_018681.1\|WP_014984236.1\|3830119_3830839_+\|haloacid-dehalogenase-type-II	gnl\|CDD\|319787	cd02588, HAD_L2-DEX, L-2-haloacid dehalogenase. L-2-Haloacid dehalogenase catalyzes the hydrolytic dehalogenation of L-2-haloacids to produce the corresponding D-2-hydroxyacids with an inversion of the C2-configuration. 2-haloacid dehalogenases are of interest for their potential to degrade recalcitrant halogenated environmental pollutants and their use in the synthesis of industrial chemicals. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	7.70194e-57

>NC_018681.1|WP_014984238.1|3831755_3831965_-|hypothetical-protein
MRKLLLSGVAGAIIASTLIAAAPAQASPPPPSLLCSAFTWPAVFLIEITGGKNGPVSPLLTPLQPLFCG
>NC_018681.1|WP_014984237.1|3830858_3831335_-|hypothetical-protein
MSPRRSPDTAGTPAAPTKLPSREDATVDARDYQQEGYYYFQSPSKNIKCGFIESNGLGTGCQLKNATVIPAELPDCGTRPDRAVAAQVVGGEGKYLCLNQGVFVGPPVDGGSEGGGKVLAYGETIVVKGTACTSSEAGIQCSQAGHGFFLAADKQSLF
>NC_018681.1|WP_014984236.1|3830119_3830839_+|haloacid-dehalogenase-type-II
MSGFDRDAVQVILCDIFGTTVDWFSGVSEQAAEIFAAAEVRLDAEVFANDWRDMYLPAMQRVREGERSWAYLDTLHRESLDSLLERHGVALDDEARARLVRSWHVLPAWPDAAAGLARLRTRYTVAALSNGGMALLTRLVKTAELPFDCILSAELARSYKPAPQVYRTATTLLDVDPDRVLMVATHGWDIDGARTAGLRTAFVERPGEKGPHRQADRPADTVSDLTASDFLQLAEILGC
>NC_018681.1|WP_041562670.1|3829370_3829769_+|NUDIX-domain-containing-protein
MIRTAALAHVRDRRLLQARSIGKEVFYMAGGKIDPGETPVGALHREVREELGVGVVSCDELGVFEAEAYGHAAGTQLHMTCFTAELDGEPRPTSEIAELRYFTVSEYAAMDHVAPGSMLVFRKLHELGFVDW
>NC_018681.1|WP_014984234.1|3828412_3829204_-|thioredoxin-domain-containing-protein
MNTSRSGWPSLPPSGDRNRTVLACMVAGALLFAVVSGVSVVIVAQDLSRDFVGTAVAAPQAQQPATGQQPAAEQQQPLAATPANVTANGAIPIGDPAAKNVVQVVADLQCPACQAFEQANATALEDAATRGSALIEYNIISFLDRASTTQYSSRAGNAAYCVAEADPAKFQGWLATMFEQQPAEGGAGLPDTELIAIAQSAGYTESTVAQCITDRRYDTYLRTKSKEIIDGGIRSTPTVLINNHPVADPKQLFTPNGLAPTLR
>NC_018681.1|WP_014984233.1|3827961_3828333_+|hypothetical-protein
MSNLDLSLKDMMVIDGALGAAVVDYNSGMALGTLGSSKALDLQVAAAGNTEVVRAKMRTIEQLGLNEGIEDILISLSGQYHIIRPMSGRKSKGLFLYLALDRTRANLALARHRLKGIEEDLEV
>NC_018681.1|WP_042255506.1|3827536_3827950_+|roadblock/LC7-domain-containing-protein
MTAPELNTTVLGELKLLRERVPQLTGALVASSDGLLVAHDLPPHIEPGGMAALAAAQLSLSYRLTTTAHGGGFHEVVVRGSEGHVVIYAAGWTSLTVLAGPDVNVGRLHLESRPVARAIADHMLANDFGTDQTTHTE
>NC_018681.1|WP_041562669.1|3827062_3827446_+|hypothetical-protein
MLDIDGCLARIMDIPGACSTTLVDGTSGLAIAAAGRHDLVDQHEDAAATTDIVRSVLHCAALATGSDDTEIIVCGTHAYHLLNPLPGDFAGQLFVHVLFDGDTGNLALARYRLRGILAEFAADDHER
>NC_018681.1|WP_081594021.1|3825781_3826678_-|hypothetical-protein
MSSTAVVTLDNLRRDLREYARLAEVGYDPAVVDPVLEPLADLWTNSVVAVRTTTHPVPERDVNVRLMHAGEPTGLVTTLRDAGLITYTGHPMEELLAAVSAAVPARAGVDVALSEGVQKIWLIFPELLSVERMLAFPGVPEAARAHAAHLSRYGGRIGILAVDFAARTMNLYSNVFEPGSLGSADIAEILADLDFTAATEEELALLGRTFNIYRTFSWTSARMQRICFPLRVQAANFPAHLHPVLARFVEGAPFVDPDTRGFVFYAAYGPTDRYYKVQAEYATGQPVTFPGGTAPRVN
>NC_018681.1|WP_014984229.1|3825480_3825681_-|hypothetical-protein
MRSDVLTCRERRQVVRRLVALCHQMNELIDVAEAESSELLLAQAHTTCRLLQDLVLDLVAAESKIR
>NC_018681.1|WP_014984239.1|3833187_3833718_-|O-acetyl-ADP-ribose-deacetylase
MTAESHRTAAIVLLRGDITRQSVDAIVNAANSSLLGGGGVDGAIHAAGGPEILAACRELRATRYRQGLPVGHAVATTAGRLSARWVIHTVGPIWSPTEDRSALLASCYRESLRAATALGAQTIAFPAISTGTFGWPLDNGARIAIDTVRSTKTTVREAHFVLFDEQGYEAFAAAAG
>NC_018681.1|WP_014984240.1|3833757_3834216_-|SRPBCC-family-protein
MTETDDVAQVVQASREIAAGADTIFELIADPAQQPRWDGNENLAEAPTGQRVRAVGDVFTMTLTMGAVRENHVVEFEEGRRIAWRPSEVGQEQPGHLWRWEIEPIDDARTRVTHTYDWSELTDEKRLVRARATTSDKLLASVDRLAELAEKP
>NC_018681.1|WP_171904484.1|3834717_3835554_-|TipAS-antibiotic-recognition-domain-containing-protein
MTRGARDAPAGTGEPIDPDGATVGRTAALVGISVRTLHHWDVIGLVQPSGRTWAGYRLYSAEDIARIHRVLVYREIGLPLADIARVLDDPAADARDHLRNQRSQLVDRIARLEEMVGAVDRMLESFRSGIRLTPQQQVEIFGDQWRSEWVEQAGQRWGDSPQWAQYAERAAHRSADDWREIAAETEQLYADLAAAKLADIAPGSDAANTLAERHRALLSRYFDCPHARHVCIARMFVDEPGYAEYHDAMAPELTQWLRDVVFANARVHGVEPETATWD
>NC_018681.1|WP_014984242.1|3835605_3836097_-|glycosyl-transferase
MNEYLSPVPVPALDAVAPEVYRSYYGMPMFITVPTADFAASEDFWLRGLGFIDIFTIPGQLIHLRRWAFQDVLLVAGEPADAAPAMRVDFSCVPSQIDEIASRCEALAPGSTSGPREMPWNALELTVITPERAHVVMTAARPIDPRSPQADALRAVGFPVPEA
>NC_018681.1|WP_014984243.1|3836130_3837030_-|class-A-beta-lactamase
MTLGDNRISRRTLLGATALLPLTACSTSTTTESAPTTQARHDRLSELERKFDARLGVYALDTASGAIIAHRAEERFAFCSTFKGLAAAAMLQRNPLSHLDTVVRYTEADLTKNAAITPQHVATGMTIRDLCDAAVRYSDGTAGNLLLRDLGGPAELTAYLRGLGDPVTRMDRIEPAITEATPGDPRDTSSPRALGTDYQRIVLGDALPDDKRAFLRDLLERNATGAGALRVRAGVPQGWKVADKTGTGDFGTLNDIAIVWPPDRAPLVISLMSSKATADAEYDQALLAEAAAYVVSALA
>NC_018681.1|WP_141692036.1|3837040_3837760_-|hypothetical-protein
MLPGSHSTALATAVLAVALTAGVAHARPIGPFEVGGAIEVEYDAAGGNAALGDPTTPESDAANGGKYQDFERNAAIYWNAAVGAHQIGGPILEKWRGLGAESGALRYPVTRVEQTPVKAGSFSHFQGGSIYWSVGTAAHQLGGVIRDKWNSLGSENSPLGFPITDEAAAKNNGRYNLFNDGAIYWSQKTGAHAVWGAIRLTWESRAGANGAYGYPTGDEYDYEGGKAQDFEGGRITWQP
>NC_018681.1|WP_029892383.1|3837876_3838578_-|hypothetical-protein
MTAATATALAALLTAGPAGARPIGPFDVGGAIEVEYDQAGGGAVFGDPVTPESDAGRGGKFQAFERNASIYWHPSTGANAVGGAIRDKWGNLGWENGVLGYPVTREESTPSKPGRYNHFQGGSIYWSVGTAAHQIGGAIRDKWAAYGWENSPLGFPITDEAAAKNNGRYNLFNDGAIYWSPKYGAHVVWGAIRTTWEARAGANGGYGYPTSDEYDYQGGKAQDFEGGRITWQP
>NC_018681.1|WP_014984246.1|3838732_3839752_+|NADP-dependent-oxidoreductase
MVESTRIVLASRPVGAPTPADFRFETTELPPLEDGQVLLRTLYLSLDPYMRGRMSDAESYAKPVELGQVMVGATVAEVLDSRDSGFAKGDVVLAYSGWQSADVASASTLRKLDPDQAPVSTALGVLGMPGFTAYSGLLKIGQPQAGETLVVAAATGPVGATVGQLAKIKGARAIGIAGGPEKCAALRDKLGFDVALDHRAPDFADQLRAAVPDGIDIYFENVGGHVADAVYPLLNTYARVPVCGMIANYNASGRPDGPDRFPAFYARILTKSLTVRGFIQTEFVRELYPDFLREVSGWIAEGRIRYLEDVVEGLDNAPEAFIGLLEGRNFGKLVVKVAD
>NC_018681.1|WP_014984247.1|3839782_3840604_-|SAM-dependent-methyltransferase
MTDSHLPPALSTKIDTGVAHEARVYDYWLGGKDNYPADRALGDAIATHIPAIRTMARANRAFLGRAVRYLVTEVGIRQFLDIGTGIPTAGNTHEVAQRLDPAARVVYVDNDPIVLAHARALMASKPQGRTAFIHADLHDPDTILRDVSLAATLELDQPVAIMLVAIMMYFRDEDKPQEIIENLLAVVPSGSYLVISHPTADFDERAMDRVVASAEQAGITFHPRSRVETEALFAGADLVDPGVVPVVTWHPDAGDTDADAESAWYWAGIGRKP
>NC_018681.1|WP_041563941.1|3841101_3841380_+|hypothetical-protein
MILAALHDTVLAEVSNPSPEAPPLADKLMQMGRYFTWLVQLSGITAITYGGGRFAWEKWSGGGLQSPKMIASAMAGGAVATSAGTIMNSVIG

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Crispr_ID: NC_018681_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_018681_9

4372048-4372210

Orphan

Consensus_repeat	Method
GCCGCTGTCGCCGAACCAATCGAAG	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_018681_9

>merge|NC_018681|9|4372048-4372210|CRISPRCasFinder
GCTGCCGCCGCTGAACCACTCGGCGTTGCCGAACGTGTCGTCGGCGCCGAACGTGCGGGTGCCGCTGTCGCCGAACCAATCGAAGGTCTGGCCGCCGTCGCCGCCGATCATGTCGGTGACGTCGGAGGCGTTGTCCCAGCCGCTGTCGCCGAACCAATCGAAG

>NC_018681|9|8|4372048-4372210|CRISPRCasFinder
GCTGCCGCCGCTGAACCACTCGGCG	TTGCCGAACGTGTCGTCGGCGCCGAACGTGCGGGT
GCCGCTGTCGCCGAACCAATCGAAG	GTCTGGCCGCCGTCGCCGCCGATCATGTCGGTGACGTCGGAGGCGTTGTCCCA
GCCGCTGTCGCCGAACCAATCGAAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_018681.1\|WP_041562722.1\|4382141_4384241_+\|phospholipase-C,-phosphocholine-specific	unknown	unknown	gnl\|CDD\|274561
NC_018681.1\|WP_014984704.1\|4366854_4367889_+\|alpha/beta-hydrolase-fold-domain-containing-protein	unknown	unknown	gnl\|CDD\|369561
NC_018681.1\|WP_014984699.1\|4361256_4362684_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|270872
NC_018681.1\|WP_014984701.1\|4363590_4364448_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|235628
NC_018681.1\|WP_014984707.1\|4370134_4371724_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224983
NC_018681.1\|WP_014984716.1\|4380502_4381081_-\|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|377026
NC_018681.1\|WP_014984712.1\|4375689_4376703_+\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|226951
NC_018681.1\|WP_167829157.1\|4371746_4371884_-\|hypothetical-protein	unknown	unknown	unknown
NC_018681.1\|WP_014984717.1\|4381187_4382075_+\|RNA-polymerase-sigma-factor-SigJ	unknown	unknown	gnl\|CDD\|236600
NC_018681.1\|WP_014984711.1\|4375239_4375512_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223564
NC_018681.1\|WP_014984706.1\|4369604_4370138_+\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|176863
NC_018681.1\|WP_014984702.1\|4364444_4365305_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|235628
NC_018681.1\|WP_014984710.1\|4374742_4375201_-\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|341424
NC_018681.1\|WP_014984715.1\|4380000_4380492_-\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|379275
NC_018681.1\|WP_014984703.1\|4365313_4366858_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224983
NC_018681.1\|WP_041564040.1\|4367917_4369480_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224983
NC_018681.1\|WP_014984709.1\|4373429_4374713_-\|ArsB/NhaD-family-transporter	unknown	unknown	gnl\|CDD\|238536
NC_018681.1\|WP_014984713.1\|4376699_4377359_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NC_018681.1\|WP_014984714.1\|4377429_4379871_+\|ATP-dependent-helicase-HrpB	unknown	unknown	gnl\|CDD\|273901
NC_018681.1\|WP_014984700.1\|4362703_4363378_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228

Protein	Function_ID	Function_description	E-value
NC_018681.1\|WP_041562722.1\|4382141_4384241_+\|phospholipase-C,-phosphocholine-specific	gnl\|CDD\|274561	TIGR03396, PC_PLC, phospholipase C, phosphocholine-specific, Pseudomonas-type. Members of this protein family are bacterial, phosphatidylcholine-hydrolyzing phospholipase C enzymes, with a characteristic domain architecture as found in hemolytyic (PlcH) and nonhemolytic (PlcN) secreted enzymes of Pseudomonas aeruginosa. PlcH hydrolyzes phosphatidylcholine to diacylglycerol and phosphocholine, but unlike PlcN can also hydrolyze sphingomyelin to ceramide ((N-acylsphingosine)) and phosphocholine. Members of this family share the twin-arginine signal sequence for Sec-independent transport across the plasma membrane. PlcH is secreted as a heterodimer with a small chaperone, PlcR, encoded immediately downstream. [Cellular processes, Pathogenesis].	0
NC_018681.1\|WP_014984704.1\|4366854_4367889_+\|alpha/beta-hydrolase-fold-domain-containing-protein	gnl\|CDD\|369561	pfam07859, Abhydrolase_3, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	8.36134e-49
NC_018681.1\|WP_014984710.1\|4374742_4375201_-\|CBS-domain-containing-protein	gnl\|CDD\|341424	cd17788, CBS_pair_bac, Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains present in bacteria. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).	3.26838e-49
NC_018681.1\|WP_014984701.1\|4363590_4364448_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|235628	PRK05855, PRK05855, SDR family oxidoreductase.	1.70767e-84
NC_018681.1\|WP_014984707.1\|4370134_4371724_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224983	COG2072, TrkA, Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism].	2.81312e-73
NC_018681.1\|WP_014984716.1\|4380502_4381081_-\|NAD(P)H-dependent-oxidoreductase	gnl\|CDD\|377026	pfam03358, FMN_red, NADPH-dependent FMN reductase.	8.55978e-46
NC_018681.1\|WP_014984712.1\|4375689_4376703_+\|HAMP-domain-containing-protein	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	3.07708e-52
NC_018681.1\|WP_014984715.1\|4380000_4380492_-\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|379275	pfam13577, SnoaL_4, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	1.60025e-19
NC_018681.1\|WP_014984717.1\|4381187_4382075_+\|RNA-polymerase-sigma-factor-SigJ	gnl\|CDD\|236600	PRK09636, PRK09636, RNA polymerase sigma factor SigJ; Provisional.	1.42631e-97
NC_018681.1\|WP_014984711.1\|4375239_4375512_-\|hypothetical-protein	gnl\|CDD\|223564	COG0490, COG0490, Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism].	5.7821e-09
NC_018681.1\|WP_014984706.1\|4369604_4370138_+\|SRPBCC-family-protein	gnl\|CDD\|176863	cd07821, PYR_PYL_RCAR_like, Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins. The PYR/PYL/RCAR-like family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. PYR/PYL/RCAR plant proteins are receptors involved in signal transduction. They bind abscisic acid (ABA) and mediate its signaling. ABA is a vital plant hormone, which regulates plant growth, development, and response to environmental stresses. Upon binding ABA, these plant proteins interact with a type 2C protein phosphatase (PP2C), such as ABI1 and ABI2, and inhibit their activity. When ABA is bound, a loop (designated the gate/CL2 loop) closes over the ligand binding pocket, resulting in the weakening of the inactive PYL dimer and facilitating type 2C protein phosphatase binding. In the ABA:PYL1:ABI1 complex, the gate blocks substrate access to the phosphatase active site. A conserved Trp from PP2C inserts into PYL to lock the receptor in a closed formation. This group also contains Methylobacterium extorquens AM1 MxaD. The mxaD gene is located within the mxaFJGIR(S)ACKLDEHB cluster which encodes proteins involved in methanol oxidation. MxaD may participate in the periplasmic electron transport chain for oxidation of methanol. Mutants lacking MxaD exhibit a reduced growth on methanol, and a lower rate of respiration with methanol.	8.92272e-14
NC_018681.1\|WP_014984702.1\|4364444_4365305_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|235628	PRK05855, PRK05855, SDR family oxidoreductase.	5.15541e-93
NC_018681.1\|WP_014984699.1\|4361256_4362684_-\|ATP-binding-protein	gnl\|CDD\|270872	cd13970, ABC1_ADCK3, Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3. This subfamily is composed of the atypical yeast protein kinase Abc1p, its human homolog ADCK3 (also called CABC1), and similar proteins. Abc1p (also called Coq8p) is required for the biosynthesis of Coenzyme Q (ubiquinone or Q), which is an essential lipid component in respiratory electron and proton transport. It is necessary for the formation of a multi-subunit Q-biosynthetic complex and may also function in the regulation of Q synthesis. Human ADCK3 is able to rescue defects in Q synthesis and the phosphorylation state of Coq proteins in yeast Abc1 (or Coq8) mutants. Mutations in ADCK3 cause progressive cerebellar ataxia and atrophy due to Q10 deficiency. In algae and higher plants, ABC1 kinases have proliferated to more than 15 subfamilies, most of which are located in plastids or mitochondria. Subfamily 13 (ABC1K13) of plant ABC1 kinases belongs in this subfamily with yeast Abc1p and human ADCK3. ABC1 kinases are not related to the ATP-binding cassette (ABC) membrane transporter family.	6.25497e-91
NC_018681.1\|WP_014984703.1\|4365313_4366858_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224983	COG2072, TrkA, Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism].	3.86365e-77
NC_018681.1\|WP_041564040.1\|4367917_4369480_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224983	COG2072, TrkA, Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism].	2.23576e-87
NC_018681.1\|WP_014984709.1\|4373429_4374713_-\|ArsB/NhaD-family-transporter	gnl\|CDD\|238536	cd01116, P_permease, Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.	4.97131e-126
NC_018681.1\|WP_014984713.1\|4376699_4377359_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.93158e-68
NC_018681.1\|WP_014984714.1\|4377429_4379871_+\|ATP-dependent-helicase-HrpB	gnl\|CDD\|273901	TIGR01970, ATP-dependent_RNA_helicase_HrpB, ATP-dependent helicase HrpB. This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity].	0
NC_018681.1\|WP_014984700.1\|4362703_4363378_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.04248e-15

>NC_018681.1|WP_167829157.1|4371746_4371884_-|hypothetical-protein
MAVSRTDRNEPALIDNVPGMLLALLLVVVIAALGLSYSLTAAIPA
>NC_018681.1|WP_014984707.1|4370134_4371724_+|NAD(P)/FAD-dependent-oxidoreductase
MTETKSATPQYEVIVIGAGIGGICAGVKLQEIGIDDFLIVDRVGGLGGTWYSHSYPDAGCDIPSTTYQFSFARKPDWDRLFAKRDQILEYLREVAADYDLPRRMRFHTTIVREEWDDRDALWRLHVDSGEVLTARFVISAVGAYINAKTTPDIPGLDSYAGVSMHPATWNHDYDFTGKRVAIIGVGASTMQIAPTLAAQVERLDIYQRTPQVYLPKPDFVLRPWMQRMLALPGGSALVNGLAQGVIDSALRVAVFTPAPLWKLGARLVDAAGRNAYAGWVRIKVRDKEVRKQLRPDFGIVCIRGGAGGDYLPTLNRDNVELITAGIGEITPHAIRSADGVEREIDALVLATGYEVFSDPESYKPGTVLGRAGFDLGVFYNTEELKAYYSTSVAGVPNRFIMIGPYSWTGTAFHYFVENAMRHIATVIDETRRRGATVVEVRPQAQERFHREMLRSGRNLSYYLETRCEGSNSYFINSQGKSPYLRPWSLLKTYRRATRFDREDYSYRSPVRDADPIVAPDIELAAAELS
>NC_018681.1|WP_014984706.1|4369604_4370138_+|SRPBCC-family-protein
MLDAPRWAVWTALDDDQAWRWLPIPCVGVRYDSPERGAGVIREMGSVFDPLRFGWVERERFWRHEPGHRITFGVVSGNWSQFLLVRQYAEDMTFTDLGADRTRVVWTVAVTPRLPLRFSTWFPPLWRAAYRIGGVGPLFARRVAQVAQTSSSPVWPISANGRPAAELTGQRAEEDVK
>NC_018681.1|WP_041564040.1|4367917_4369480_+|NAD(P)/FAD-dependent-oxidoreductase
MSSTSTPDFDVLVIGAGFGGLGTGAALRRAGIDNFLIIDKWQRVGGTWNANTYPGVAVDVPSPIYNFSFQQRSRWSRFFAPGAEIQRYAEEVADRQGLRDKLRLGCGAMRARFDEATDQWRVLTTDGDEITARFLVSAVGALEQPKPPAIAGLDRYTGTLMHTARWDHSYDYRGKRVAVIGTGATALQVIPRLAEQADQLTVFQRTAIWVAPKPDFALGRIGHRALDFPPTQQAIRLIGNAAVNAFLGIGLALSDYPRLTSAVLGAGEAALKAYLFTQVRDRGLRRALTPTYRLGCKRPSISNNYFKTYTRPHVDLVTTAIERCTEQGIVTADGTHREFDMVVTATGFQVMDKGATPPYPVHGCGGTELGEYWDTHRYQAYEGVSVPGFPNMFHIFGPYGYAPGSVIPLIEATAAHSSRVIAEALRRGATRAEIRREPHEEYFARMYARNKNTYLFKQGCAESRTYYINYQGDGPAFRATTQLGMYWSNRHFPLDHYRYTTSRMVPAAGDAPARQSIVTH
>NC_018681.1|WP_014984704.1|4366854_4367889_+|alpha/beta-hydrolase-fold-domain-containing-protein
MTGAAAAVQVEFASRAGLRLRVAHALLRATLRPAVDGLCVLAESGPLRGTRAFRIANLADLLAIPLRPARGTRRRAVLFPDFRAEWLWHRDDHGPDDTAQGAAILYFHGGGFLAGGLHSHRRLAARIARAAGVALLNVDYRQLPKGHFTDTVDDAVTAYRYLLDRGFTPDRVVFAGDSAGGGLTFAAALAARARALPLPAAIAAIAPFADLDPAIRRAHPNDRHDALLSARALAVPALLGFARDGVLDPLWSPINHDFTGMPPTLIQVSNLEVLLPDAEALARRCATAGVPHTLQVWDNAIHVFHAGADLLPDARAAVAELGAFVRRALDTAAAGRGTDRTTAA
>NC_018681.1|WP_014984703.1|4365313_4366858_+|NAD(P)/FAD-dependent-oxidoreductase
MNETAAPLYEVAVIGAGPGGIAAGVKLRRAGIDDFIVLERSDEVGGSWHENHYPGLGVDIPALAYQYSFARKANWSRVFPHGAEVEQYHIDVARRFGVRARVRFGAEVEREEWDEHAGYWRLFLADGSIVSARFVISAVGAFVRPKTEVGIAGVRAFKGKVLRPSSWDHDYDLSGKTVGIIGTGASAVQIIPSIAPEVGKLTVFQRTPVWSLPKPDFRIPGALQRVLAVPGIQPVLHGGALVVIDLALRAVVGLPGGVVHPAMDRFDAGCRALYRRYLARVVTDPQTRTALTPDFGLVAKRPTLSNSYLRAYNRDNVALVTTPIEKITPTGVRTGDKTLHRLDALILATGYEVFSDPETYRPGTILGRNGFDLAKFYREEGLQAYQSVSVHGLPNRWTLVGPYSWTGSGWHAFVEMTADHAVRAIAETRRRGALWCEVRKEAADAYHRTVYRRGESLRYYLAELNGHVPTYYRNSQGDTTYVRPSGFFEARRGNRRFPLDDYRYEVQVPAGVPA
>NC_018681.1|WP_014984702.1|4364444_4365305_+|SDR-family-NAD(P)-dependent-oxidoreductase
MRTAIVTGGGAGIGRETALLLARTGYRVVIADIDADSAHAAADEIGAAGGRAHPYRLDVASESQWDKCAEWVSGEFGPAHVLVNNAGVMDTGGFFETTAAQWQRTVDIDLMSVIYGSRVFARQMIDAGIPGHIVNVSSGAAFFPAKYIPAYATAKAAVLMATQALRVELRPKGIGVSAICPGAIRTDLLAHGERAGLDAAQQAAWRTEIGRVQGLAFAGPDKVARAIERAIRRDHAIVPVNLEAWLGYGAFRLSPSLTRVVGSLGSFTLADALLPRLRPLLNRITK
>NC_018681.1|WP_014984701.1|4363590_4364448_+|SDR-family-NAD(P)-dependent-oxidoreductase
MTVVVVTGAGSGIGRAISLRFAGRGATVLVADIDECGGKETVALVRAAGGRAEFSPLDVSDATALAEFAARVARDHGVPDVVVNNAGILISGGFLEQSGDDWRRMIAINMLGPLLGSRLFVQQMVEAGKHGAIVNICSVGAFLPTSLAPSYVTAKAGAWMGTQALRAEFADRGIRVSAVCPGLIDTELSANGTLAGADARATADWGAKLARGQRIFGRSPDRVAAAVERAVRWNLSTVPVGVEAWAGWYLARLSPGVLRGLSGLAQMPLAEKAVELSDRVLGGRR
>NC_018681.1|WP_014984700.1|4362703_4363378_-|TetR/AcrR-family-transcriptional-regulator
MTEPAKRGRGPGRPRDQQNTERRRRELIAAAYHVFTTKGYAAASTADITAEVGIGYGTFYRYFDSKRAILDEVVDYGLDRILTEIAGEVFVPEPVHREITVDWLVRTWSGAVERMCRIAESDPALMQALLFELPGIDDELNTRLLGLGGILAATVDRFLTRAVDAGVLRADVHTADVAWMLMALTIPPVMRTLQGGGEADRRGYTDTVLAVLTSGLQSPGQAKN
>NC_018681.1|WP_014984699.1|4361256_4362684_-|ATP-binding-protein
MAKDIPTSRVRRGATFGKLVAGQAVRGAGVTLSMVGDTDAQRTARTERALADAAEDIVTVLGSMKGLAMKAGQLLSMFDLLAAFGIETMPPAQRERFQRKLAALYDQAPSLPFERMRTVLEADYGRPLAKVFAEFEATPIGTASIGQVYRARLHDGRTVAVKVQYPGIDIAIRADLKNLGLVLRMLRTIAPAVADHALFRELTTHFADETDYRAEAAHHRIVADSYRDHPFIRIPEVVTELCTARVLVTELVEGLRFDEIVALPDADRDRVGEIVYRFYVGTMAREHCFSGDPHPGNILLAADGKVAFLDFGLFKHMDDAAVEFELDCVRAAAEHRGAELRGLLTEYGVLEEDSPATADECLRLFYEVSGWLLTDAEIRIAADAAPNAILTFVDPRRGYFDRWRREYAPAEHAFARRVEYGTLALLGKLRAAGNWHRIAREWCYDEPPRTELGVLEHDWLATRGRDAQGDPRHRH
>NC_018681.1|WP_014984709.1|4373429_4374713_-|ArsB/NhaD-family-transporter
MTQLLALTIFVGAFWCIATERADKVKIVLVAAGLMTVLGLVPGEQVFYSAHNGIDWNVIFLLLGMMIIVGVVKHTGLFDFLAIWAAKRSRGKPFRLMVMLMVITAVASPLLDNVTIIMLVAPVTIVVCDRLRLPAQPFLIAEILAANIGGAATLVGDPPNIIIGSRAGLSFNDFLVHMAPAVTVIFVLFVLFTRWLFRKHLRHDSAHIEVVMALHERRAITDPRLLARSLLVLAAVVLGFGLHSVFHIAPSIIALLGAGAMVLISDLDVGDILREVEWGTLVFFMGLFVMVAGLVHTGVIDRIGDAAVTAFGDNPLLASATLVFGSAVVAAFIDNIPYTTTMAPVVEGLVAETPNPVHGQALWWSFAFGADFSGNGTAVAASANVVALDIARRAGHPITFWTFTKYGILVTALSTTFAWIYLWARYF
>NC_018681.1|WP_014984710.1|4374742_4375201_-|CBS-domain-containing-protein
MQAREIAIQLPTVRVADPVAKAMRLMVVNRLPGMIVVDDADRPIAVLPGTQVLRLAIPSSYQNDPALVRTIDELHAELFWQEPGRWTVGDCLPETIAKPATIRPDATLLEVAALMAQKHSPLVAVVDRDRTLLGAVTLERLLLSLAIAGPED
>NC_018681.1|WP_014984711.1|4375239_4375512_-|hypothetical-protein
MDVDRTTVPGRGTVHHFLARGGARFALLTASDGDKHVLVYDDTGDEPVQIVALEPDEADQFAALLHSAPLPDRVARLERLLDTLADDRNR
>NC_018681.1|WP_014984712.1|4375689_4376703_+|HAMP-domain-containing-protein
MDRPDSAASLFRRGPRTPAQALYRRIFLINGAVFTLGTLVLALSPATVSARVRLTEVPVLLIGLAVILAANALLLRTSLAPLDGLIASMDRVDPLRRSGRFDDRGNGDLSRLIDTFNAMVDRLATERTAASASALAAQEGERRRIARELHDEIGQSLTVALLSMKRAADRSPADVAEVLHGAQETVRGCLDEVRNIARRLRPDVLDDLGLASALAALCGEFATTAGITVARTVDRDLPRLAEEVELVCYRIAQESLTNIARHAQATAVRLSLSARDDTLVLRVRDNGRGGVVEDGAGIRGMRERALLVDATLVIDSAPGHGTEVCVTIPQHHSGGSS
>NC_018681.1|WP_014984713.1|4376699_4377359_+|response-regulator-transcription-factor
MTTAAPARILLADDHALVRSGLRLILDAEPDLTVVAEAANGYDAIQQIAATPVDLAILDIAMPRLTGIQAAREIAGSNPQVRILMLSMYDNEQYFFESLRVGASGYVLKSVADRDLLEACRATLRGESYLYPGAVNSLIRDWLHRARDGEALPRSILTPREEEVVKLVAEGFSSREIAGDLFISVKTVDRHRANVMQKLGLRDRLALTRYAIRAGLIEP
>NC_018681.1|WP_014984714.1|4377429_4379871_+|ATP-dependent-helicase-HrpB
MKLPELPELPVRPALDGLVETLAERATAVLVAPPGTGKTTLVPLALAAAGTGRVLVAEPRRLAARAAAARMAALLGEPVGETVGYSVRGDRRVGPGTRIEVVTSGLLVRRLQGDPELPGVDVVMLDECHERHLDADLLLALLLDARAGLRPDLRVLATSATVAAERLSALLDPDRGAPVVQVDGRTYPVRTTYVPPLPREWVEAQVARAVRAALVGTEGDVLVFLPGAAEIRRTTALLADLSEVDVVPLHGRLSAAGQDSVLRPGVRRRVVLATAVAESSLTVPGVRAVVDSGLARVPRIDRGRGLSGLATVRVSAAVAEQRAGRAGREAPGHVWRCWPEYEHATLPAYPEPEIRTADLTRLALELACWGTADGHGLAWWDAPAPGGLAAGREVLRALGAVHDDGTVTDRGRRIAGIGLHPRLARALLDGAAEVGARAAAEVVTVLDDDTLLSGVDLVSGLRTLRRARPGRWQREVARLARAVAAPDGRDEPAFVVALAYPERLARRRAPGSTSYLMAGGTAVTLPPGSGMGDAEWLAVGVATRDPGRSDGQIRLAAVADEQLARRAAASLLSTVDEVDWVDGDVVARRVERLGAIVLSERPIRDPDRELLSAAVCRGLQERGLEVLRWDAEAVSLRHRLDFLHRTLGAPWPAVDDAALLADAELWLGPELAVARNRADLARVDAGTALRRLLPWPEAAQLDELAPERLTVPSGSRPRLDYSADPPVLAVKVQEIFGWADAPRLAGGRVPIVLHLLSPAQRPVAVTADLASFWQAGWLQVRADLRGRYPKHAWPEDPTTVPAHRGTARNAGGN
>NC_018681.1|WP_014984715.1|4380000_4380492_-|nuclear-transport-factor-2-family-protein
MLIPNDFRALADRIEIAALGAEFSDAVMMRDPDRLLTLFTDDAVLRIPDAQIELTGRAELQHALPRMQAAWEYFIQHTHAGVVELDGDTAAGRAPILELGRLKSGSSHSNYAIYHDRYRRTPDGWKFTERVYEIRYLDNSPLPGAPPGEHGLDVDVSAARLQG
>NC_018681.1|WP_014984716.1|4380502_4381081_-|NAD(P)H-dependent-oxidoreductase
MTIRIGIILGSTRPNRNGPQVAQWVLDTAAARADAEFDLVDLREHPLPHLDEPVAPMFGPSVHAHTRAWAERIAPFDGFVIVTPEYNHGAPGVLKNAIDHLFAQWADKAVGFVSYGAGGGALAVEQLRQVCSALGMADVSPQVTISVLTDFENYTAFRPTERHTVALDKLLEKVVAWSTALAPLRQSTLVTS
>NC_018681.1|WP_014984717.1|4381187_4382075_+|RNA-polymerase-sigma-factor-SigJ
MTDPQPRPVLSERRQLINLAYRLLGSLAEAEDVVQEAYARWYALSDAQREAVAEPGAWLTTVAGRICLDLLGSARARRERYVGEWIPEPVPGRSEWLGGPMPADPADRVTLDESISMAFLVVLESMTPAERVAFVLHDVFRYSFAEVADVVGRTPAACRQLASSARRRIRTSRDVTLTERAEVVQDFKKAWETGDIEALVGLLDPQAIATADSGGLAPAFRQPISGGARIAAAWLEIAARAPEVTLIERTVNGQPGLVALVAGTIVSVYAFDIADRRITRIWVIRNPDKLRPWTE
>NC_018681.1|WP_041562722.1|4382141_4384241_+|phospholipase-C,-phosphocholine-specific
MVPMSRRHLFGSMAAAAAASLLPPSLHRAMAAPMRRGGLAEIEHVVLLMQENRSFDHYYGTLRGVRGFGDESPLRLRTGRSVFHQPQPAPPGQFPAPDAEVLPFSLRAAAARAGRPDSDIEYLDALNHEWYGSTAAWAQGWYDGWIPAKTPATMTYYERRDIPLQYELAETFTICDAYHCSLFGGTNPNRNYFFTGTTGFEPGTRKRAVANDAYEIDHPGYAWTTYPERLEAAGVSWQIYQEWDNFTDNPVEYFLPFKRIGTRLLAEVDGGYRTTEQLYTALLTLPEADRQRLLGRLDAALGGLTAQQRSLFDRAMYRSAPGTLLQRFRADVTAGTLPAVTWLVPPQALSEHPSGSTPVASANLIYELLDVLASDPGTWSKTALFITFDENDGFFDHVPPPVPPRPADGEGDDWYQGQAIGLGPRVPMVVVSPWTIGGFVDSEVFDHTSVLRFLETWTGVAEPNISEWRRTACGDLTSAFDFTNPGRPPTLHRPGPVPAPVTRWMPDPPPAQSVPEQEPGRRPARALPYQPTVSAVLRSPTRLAVTLRNTGARPAHFALYSYAGESGFPVHLDVVHEATEIVTVAGDYDVAVQGPNRFWHELRGNTSGAAADIVVRQLIRRGSLSVDLANGGGDEVTLTLSSRRCTATRHEVILPPGTTKSVDWPTDDGWYDLTVACTEDPTFSRRLTGRIEPPAVEVD

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Crispr_ID: NC_018681_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_018681_10

5736815-5736894

Orphan

Consensus_repeat	Method
CCTTGGTATATACCAAGGTTCAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_018681_10

>merge|NC_018681|10|5736815-5736894|CRISPRCasFinder
CCTTGGTATATACCAAGGTTCAGGAGTTGTTAACCCCTCCGACAGGCAAACAGCACTCCTTGGTATATACCAAGGATCAG

>NC_018681|10|9|5736815-5736894|CRISPRCasFinder
CCTTGGTATATACCAAGGTTCAG	GAGTTGTTAACCCCTCCGACAGGCAAACAGCACT
CCTTGGTATATACCAAGGATCAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_018681.1\|WP_014985809.1\|5723528_5724752_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NC_018681.1\|WP_051067007.1\|5742260_5743535_+\|hydrolase	unknown	unknown	gnl\|CDD\|224594
NC_018681.1\|WP_014985828.1\|5744549_5745959_-\|threonine/serine-exporter-family-protein	unknown	unknown	gnl\|CDD\|377697
NC_018681.1\|WP_014985817.1\|5733197_5733422_-\|hypothetical-protein	unknown	unknown	unknown
NC_018681.1\|WP_014985822.1\|5738001_5738817_+\|phosphonate-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213223
NC_018681.1\|WP_014985818.1\|5733609_5734119_+\|FAD-dependent-monooxygenase	unknown	unknown	gnl\|CDD\|235728
NC_018681.1\|WP_014985824.1\|5740381_5741392_+\|alcohol-dehydrogenase-catalytic-domain-containing-protein	unknown	unknown	gnl\|CDD\|176193
NC_018681.1\|WP_141692100.1\|5727980_5728844_+\|hypothetical-protein	unknown	unknown	unknown
NC_018681.1\|WP_041562866.1\|5731852_5732998_-\|FAD-dependent-monooxygenase	unknown	unknown	gnl\|CDD\|223727
NC_018681.1\|WP_193364881.1\|5729842_5730160_+\|cold-shock-domain-containing-protein	unknown	unknown	gnl\|CDD\|239905
NC_018681.1\|WP_014985810.1\|5725361_5727968_+\|hypothetical-protein	unknown	unknown	unknown
NC_018681.1\|WP_014985812.1\|5729088_5729454_+\|hypothetical-protein	unknown	unknown	unknown
NC_018681.1\|WP_014985819.1\|5734400_5735840_-\|phospholipase-C	unknown	unknown	gnl\|CDD\|274561
NC_018681.1\|WP_141692109.1\|5738909_5740406_+\|phosphonate-ABC-transporter,-permease-protein-PhnE	unknown	unknown	gnl\|CDD\|273441
NC_018681.1\|WP_041564330.1\|5746391_5747096_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|133013
NC_018681.1\|WP_014985821.1\|5737030_5737999_+\|phosphate/phosphite/phosphonate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270232
NC_018681.1\|WP_041564328.1\|5743796_5744480_+\|ANTAR-domain-containing-protein	unknown	unknown	gnl\|CDD\|198080
NC_018681.1\|WP_141692110.1\|5741457_5742090_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_018681.1\|WP_014985820.1\|5736074_5736797_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225099
NC_018681.1\|WP_014985830.1\|5747095_5748037_+\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173838

Protein	Function_ID	Function_description	E-value
NC_018681.1\|WP_014985809.1\|5723528_5724752_+\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	7.75324e-59
NC_018681.1\|WP_051067007.1\|5742260_5743535_+\|hydrolase	gnl\|CDD\|224594	COG1680, AmpC, Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms].	3.54416e-30
NC_018681.1\|WP_141692110.1\|5741457_5742090_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.43711e-10
NC_018681.1\|WP_014985822.1\|5738001_5738817_+\|phosphonate-ABC-transporter-ATP-binding-protein	gnl\|CDD\|213223	cd03256, ABC_PhnC_transporter, ATP-binding cassette domain of the binding protein-dependent phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all kingdoms of wildlife, but only prokaryotic microorganisms are able to cleave this bond. Certain bacteria such as E. coli can use alkylphosphonates as a phosphorus source. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	1.43195e-105
NC_018681.1\|WP_014985818.1\|5733609_5734119_+\|FAD-dependent-monooxygenase	gnl\|CDD\|235728	PRK06184, PRK06184, hypothetical protein; Provisional.	6.4136e-32
NC_018681.1\|WP_014985824.1\|5740381_5741392_+\|alcohol-dehydrogenase-catalytic-domain-containing-protein	gnl\|CDD\|176193	cd08231, MDR_TM0436_like, Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH). This group contains the hypothetical TM0436 alcohol dehydrogenase from Thermotoga maritima, proteins annotated as 5-exo-alcohol dehydrogenase, and other members of the medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family. MDR, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability.	4.53147e-128
NC_018681.1\|WP_014985828.1\|5744549_5745959_-\|threonine/serine-exporter-family-protein	gnl\|CDD\|377697	pfam06738, ThrE, Putative threonine/serine exporter. ThrE is a family of bacterial and Archaeal proteins that catalyze the export of L-threonine from the cell. UniProtKB:Q79VD1 has been characterized as being necessary for this export. The domain exhibits 10 putative TMs and catalyzes the proton-motive-force-dependent efflux of threonine and serine.	3.22626e-22
NC_018681.1\|WP_041562866.1\|5731852_5732998_-\|FAD-dependent-monooxygenase	gnl\|CDD\|223727	COG0654, UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion].	3.63361e-25
NC_018681.1\|WP_193364881.1\|5729842_5730160_+\|cold-shock-domain-containing-protein	gnl\|CDD\|239905	cd04458, CSP_CDS, Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. CSP expression is up-regulated by an abrupt drop in growth temperature. CSP's are also expressed under normal condition at lower level. The function of cold-shock proteins is not fully understood. They preferentially bind poly-pyrimidine region of single-stranded RNA and DNA. CSP's are thought to bind mRNA and regulate ribosomal translation, mRNA degradation, and the rate of transcription termination. The human Y-box protein, which contains a CSD, regulates transcription and translation of genes that contain the Y-box sequence in their promoters. This specific ssDNA-binding properties of CSD are required for the binding of Y-box protein to the promoter's Y-box sequence, thereby regulating transcription.	0.000650521
NC_018681.1\|WP_041564330.1\|5746391_5747096_+\|glycosyltransferase	gnl\|CDD\|133013	cd02522, GT_2_like_a, GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function. Glycosyltransferase family 2 (GT-2) subfamily of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.	9.92454e-14
NC_018681.1\|WP_014985819.1\|5734400_5735840_-\|phospholipase-C	gnl\|CDD\|274561	TIGR03396, PC_PLC, phospholipase C, phosphocholine-specific, Pseudomonas-type. Members of this protein family are bacterial, phosphatidylcholine-hydrolyzing phospholipase C enzymes, with a characteristic domain architecture as found in hemolytyic (PlcH) and nonhemolytic (PlcN) secreted enzymes of Pseudomonas aeruginosa. PlcH hydrolyzes phosphatidylcholine to diacylglycerol and phosphocholine, but unlike PlcN can also hydrolyze sphingomyelin to ceramide ((N-acylsphingosine)) and phosphocholine. Members of this family share the twin-arginine signal sequence for Sec-independent transport across the plasma membrane. PlcH is secreted as a heterodimer with a small chaperone, PlcR, encoded immediately downstream. [Cellular processes, Pathogenesis].	0
NC_018681.1\|WP_141692109.1\|5738909_5740406_+\|phosphonate-ABC-transporter,-permease-protein-PhnE	gnl\|CDD\|273441	TIGR01097, PhnE, phosphonate ABC transporter, permease protein PhnE. Phosphonates are a class of compound analogous to organic phosphates, but in which the C-O-P linkage is replaced by a direct, stable C-P bond. Some bacteria can utilize phosphonates as a source of phosphorus. This family consists of permease proteins of known or predicted phosphonate ABC transporters. Often this protein is found as a duplicated pair, occasionally as a fused pair. Certain "second" copies score in between the trusted and noise cutoff and should be considered true hits (by context). [Transport and binding proteins, Anions].	9.56051e-74
NC_018681.1\|WP_014985821.1\|5737030_5737999_+\|phosphate/phosphite/phosphonate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270232	cd01071, PBP2_PhnD_like, Substrate binding domain of phosphonate uptake system-like, a member of the type 2 periplasmic-binding fold superfamily. This family includes alkylphosphonate binding domain PhnD. These domains are found in PhnD-like proteins that are predicted to function as initial receptors in hypophosphite, phosphonate, or phosphate ABC transport in archaea and eubacteria. PhnD is the periplasmic binding component of an ABC-type phosphonate uptake system (PhnCDE) that recognizes and binds phosphonate. PhnD belongs to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. The PBP2 have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	6.6279e-65
NC_018681.1\|WP_041564328.1\|5743796_5744480_+\|ANTAR-domain-containing-protein	gnl\|CDD\|198080	smart01012, ANTAR, ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the domain consists of a coiled-coil.	1.01626e-14
NC_018681.1\|WP_014985820.1\|5736074_5736797_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	1.85755e-46
NC_018681.1\|WP_014985830.1\|5747095_5748037_+\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173838	cd00567, ACAD, Acyl-CoA dehydrogenase. Both mitochondrial acyl-CoA dehydrogenases (ACAD) and peroxisomal acyl-CoA oxidases (AXO) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. In contrast, AXO catalyzes a different oxidative half-reaction, in which the reduced FAD is reoxidized by molecular oxygen. The ACAD family includes the eukaryotic beta-oxidation enzymes, short (SCAD), medium (MCAD), long (LCAD) and very-long (VLCAD) chain acyl-CoA dehydrogenases. These enzymes all share high sequence similarity, but differ in their substrate specificities. The ACAD family also includes amino acid catabolism enzymes such as Isovaleryl-CoA dehydrogenase (IVD), short/branched chain acyl-CoA dehydrogenases(SBCAD), Isobutyryl-CoA dehydrogenase (IBDH), glutaryl-CoA deydrogenase (GCD) and Crotonobetainyl-CoA dehydrogenase. The mitochondrial ACAD's are generally homotetramers, except for VLCAD, which is a homodimer. Related enzymes include the SOS adaptive reponse proten aidB, Naphthocyclinone hydroxylase (NcnH), and and Dibenzothiophene (DBT) desulfurization enzyme C (DszC).	3.08432e-12

>NC_018681.1|WP_014985820.1|5736074_5736797_-|GntR-family-transcriptional-regulator
MTASTEPRELKHQALRAKLEKLLDGMSAGDPFPAERELAERYDVSRETVRQALRAVLLQGRIERRGRTTIVASPKVVQPLMIGSYTEAALADGRSASRILVGWTHLVADEELAGHLHVEVGAPITQLERVLTTDGYRVGLETTQLPAERYPGMFDNFDHTSSLYAAIMERGIKFERTEDSIDTTLPDAREAALLTVDARTPMFLLNRISYDQNGIPIEHRRSLYRGDRMTFTTTLRSRHD
>NC_018681.1|WP_014985819.1|5734400_5735840_-|phospholipase-C
MIVDESDTAARGFTRRRLLGGAALAAAFAAMPPNVQRVLADPVTPRPIEHVVLLMQENRSFDHYFGTMPGVRGFSDPEALRFPDGTSVFKQPDPQNPDGYTLPFHLDTYRNSVQKIPSTSHAWSVQHEALNGGKMDKWLPAHRKADGKNGPYVMGYYERADIPFHFALADAFTVCDAYHCSVLGPTWPNRMMWMTGTIDPAGRHGGPLIRNKTPAGGFTWTTYPERLEQAGVSWKVYNEIDDYGLNMLEQFAQFRGLPTDSPLYTKGIATAPIGQFERDAREGNLPAVSWILPNAAACEHPDHRPADGAEFIADRINALAANPQLWAKTVFILTYDENDGLFDHVVPPLPPKNEKDEFVDGAPIGGGYRVPTILVSPWTAGGWVATERFDHTSCLRFLEWFTGVREPNISGWRRKTFGDLTSALRLTQPPAMTPTTFPGVDAEVTRADATDKLPLPGIPADPQSEPAQEPGTKPRVGPR
>NC_018681.1|WP_014985818.1|5733609_5734119_+|FAD-dependent-monooxygenase
MLWIGQFDVEHALRERFRELGGAVEYATEAVGLVQDSDRVTVTVRAAAGARTITARYVVGTDGGKSTTRHLIGLPLEGETREEERWYLGDVTVDGLPRDRTHVWTSSAGKLNLTPVTAPRTSPACTAPAALSTCSTSPVVRSGPCWPSTSTRRPRIPALEHIAPPGGCP
>NC_018681.1|WP_014985817.1|5733197_5733422_-|hypothetical-protein
MLAGASGIAVADPDGTGAYVECAYSLPDGRTDTWDLFVRSGGTLEQSAPEAKETIYRYIEKEGGTVIRCDVDRV
>NC_018681.1|WP_041562866.1|5731852_5732998_-|FAD-dependent-monooxygenase
MAQTPDLHHTPVTVIGAGLGGLTLARVLHLHGIPATVYEAELSPKARAQGGLLDIHSYNGQLAVEAAALSKEFRALVLEGRQAVRVLDKHGNVLVDLPDDGTGGRPEVQRGELRQMLLDALADHTVQWGRKVSGTRALGAGKHEVTFDDGRSIVTDVLVGADGAWSRVRPLLSCATPEYVGVAYVETVMSDADTRHPAAAKLVGGGTMTAPAPGKGIHAHREKGGTLRTYAQLAKPLDWFAAIDFTDVAAATARIAREFDDWASELTALITDGDAEPVFRPLYTLPIEHRWERVPGVTLIGDAAHLSIANGEGANLAMLDGAELGKALATHPDDVEAALRKHERTMFPRSAKAAAEGVELLEHLSSDNGVQRLLETLTRQD
>NC_018681.1|WP_193364881.1|5729842_5730160_+|cold-shock-domain-containing-protein
MSDRGVVREWRVEEGWGVIDAPSVPGGCWVSFAALKFERRNLDNGQRVEFEWEPAEQDGYDFRAVRVWPEGAAPVEPQTRQAGQGMTMAAWDIDPITNQRHQIDE
>NC_018681.1|WP_014985812.1|5729088_5729454_+|hypothetical-protein
MTFDAAQPRESYDTKVFTWTFHLSDFMINKGINGLNTRMGCLTWLTRNGEPQSWYQDKSHKDLPITYQYHGSIPNNVEYDKYQLFGTCQFTNNTVRKKPNGSIAYGVTLAQFGHAYQFIKR
>NC_018681.1|WP_141692100.1|5727980_5728844_+|hypothetical-protein
MATPAATPAPAPGVFRPLPLPPDLAAARAAGRRVGIAYGEFAAWEKYFLGLFAEGGVVQGVALWDRLPPERRLEAIALVKNAYDSLPKLPPSTSIAMARVLRQGFEEGAKAGYEAELFATRAVWVACELAKAYATAKASTPVPYHVGASINLTRDCTSHTAARAILEMTGVEVPVDRLVRNFGVPKVSIASYRDAVSYARNWFERVGIRLGAKPVDLLQAIQRRAVGRYVVFFQGEGHVVFAEITATETRIIDDQAGKMWHTIIEAQNYLKEPIGAANRIESIVLPF
>NC_018681.1|WP_014985810.1|5725361_5727968_+|hypothetical-protein
MVLTSATRQIEKATLVPLTVPVPQTGHALVKSGFVGQLELRPDEVDAAVALLAEQTSRDESSAAMPALLRSCAGVQGAARPWPGDFAALPLDRLLAFGHALTEVRRRRLETASPSEVESLRQAVLAASTATQGLALVTAESPLGMLNLERLEMAPAGLERGELIATVPLAPMEETAVVHKEWSVRTKEFTSIVTDSLEEFSETGVTDNTELAQSTNSQTQHSNQFNVTGTVSGGIPVISGSASSGFSAQGSESQSAADSRKHAKTLTEKASTRSKQEHKVTISTTTVTGSEMSTTRKLRNPSETEPIRVDYFSMMRKWRVRLYRYGLRLTYDIVIPEPGAAMRAAHKELEQLKSRLGPFEFTVPFSDITEEVRAGETQPHYRVLADRYDAQNVPLPPKAHPPIAYRAYDGGTPKDRFVTQRTLDGIPADNEILDVTIDGRMERYNDTIGRFSVIGTSLYIPSFPPNKEYVFPAGTVLRRNTDGGNFLAGATGSPVVVFFWDEVATQSVQLTVRFQPTERAIDQWKSDVWTALFNAAQTRYFAEQQDIATRIQQLEQRLNGVDTLTLRREESDEIMKGVVRFIAGEAYQYMADGAITAFDKASIDSGGASQAAYGIGFVANNLEIDDKDMAAVRQHERLVRLINQAIEWENVVSFLYSYFWDTPKSWDFVRDLQHPDATRQAFLRAGAARVVLTVRKGFEDTWLKFAESGFTSPEFEPDARYLRIAQEIAAYDDRNYPGIPPANPARTATRLQDAVYAASNAVVRASESPVTIKVDSTVGFVVGERVVIDSADNRDAEGRVIQESQPITAVLDATRLVVARLRYDHDGSATPFAVVQPGMKGALIAEWTEYTPTSGTDIAITSDLTEIA
>NC_018681.1|WP_014985809.1|5723528_5724752_+|MFS-transporter
MSASLGSAFWWLWGSSGSSNLGDGIVKVGAPLVAIQYTRSPMLVASIGVAVSLPWLCALPAGALVDRVDRRRVMLGANGTRAGLVGVLALAIVLDIGSIWLLYAVVFALGLTETIYDTAAQAILPQVVRRDQLSRANSRLFAVELTANEFVGPPLAGLLIAGGAALAFGIPAALWGLAIVALFLVPGRFRVQRTHRSTVRADINEGLRYLRRHQILRTLAVMTGGFNIATEAMMAILVLYAVGPGSAMGLAEQAYGIVLAAFAGGALGGSFVAARIERVLGRSRALAVALLSGALSVGIPAVTANPWAVGAGFFLAGVGLMLWNVIVVSLRQRIIPHRLLGRVSSSYRLVAWGSRPLGAAAGGVLAQLFGLRAVFAVMALLILSTLTGLWVVTDERITAAEREAGHA
>NC_018681.1|WP_014985821.1|5737030_5737999_+|phosphate/phosphite/phosphonate-ABC-transporter-substrate-binding-protein
MKNRFRRHAVTTAAVLTGLALVASGCSSTDPNARNAKGFPETLTLAAVPAENSADLKASYAPVVKLLERETGSKVEFKQASDYAGVIEGIIAGNVDLAFFGPFAYVVAGLNKAEITPLGAVIKAAGAKPGYQSYGLTKSDNASINGLKDFAGKKVCFVDPSSTSGYLYPTAGLIEANVIKSGSVADISAGVTPIYAGAHDASALSIASGACDAGFAFDTMIDKTMIDKGDLRAGQLKTVWKSETIAGSVFAANNALGTEVIEKLKAVFTTGLNAADLKSSGICSDECRITDERAWGVVPATDADYNGVRKVCEITGSKKCKS
>NC_018681.1|WP_014985822.1|5738001_5738817_+|phosphonate-ABC-transporter-ATP-binding-protein
MPVDNPVAGDDLVIAAHGVSKRFGPTLALDEVSLEVRRSEFVVLLGLSGSGKSTFLRCLNGLHPVTSGTITVNGTSVDRAGSAELRRLRREVGFVFQQFNLVGRLSCLENVLIGGLGSLTIPRYGALAYPKRMRAAARAYLERVGLAEFAERRADTLSGGQQQRVAIARTLMQRPSILLADEPVASLDPENAGIVMDLLFQICVEEKLTVVCTLHQVDLALGWAHRIVGLRGGAKVMDRPTAQMSREDAMEIYRRVDPESTEYIATSADSA
>NC_018681.1|WP_141692109.1|5738909_5740406_+|phosphonate-ABC-transporter,-permease-protein-PhnE
MIATGCAAWWIDFAPMTLLAGLDHVRSLLERMLPPTLDDPGRIWELAIQTLLMAILGTALAAAVSVPLAFLAARNTTPHPLVYTVARAAITFCRAMPDLLFAVLFVRALGIGVLPGILALALHSIGMLGKLFAESIEATEHGPREAVRSTGVGYFREMLNAVVPQVVPAWIASFVYRIDINLRMSVVLGFVGAGGIGFALQDALRGLMYPTALGIVCVMLAIIAAMEVLAIVVRKIMLAPARADPRRDRIARITFSALVFGSCAAAFAELGISPWSLATWVGPSIRTFTRLVPPNFGALGAELFTAALETVAIGIVATAIGIALSIPVGIMAARNVTPHAGVYWLARAWILAIRAVPELILAVVFVAAVGLGPIAGACALALGSIGFLAKLVADAIEEIAPGPLEAVRAVGGGWWKTLFAAVLPQAMPALVGSSLYLLDVNIRTSTILGVVGAGGIGYLLFESIRTLQFDVAGAIVIVMFLIVYAIERLSGWIRSLLG
>NC_018681.1|WP_014985824.1|5740381_5741392_+|alcohol-dehydrogenase-catalytic-domain-containing-protein
MDSITPRVTRAAVWTGHGVELREIELPDLAAGDTLVRVRLATVCGSDLHTVAGRRPAPCPSILGHEAVGEVVVAGSDIPAQVGDRIVWAVTVACGRCARCRAGFTAKCASVRKFGHEPFDSDWPLSGAYAEYVVLPRGASVARVPDTLTDAVAAPAACATATVMAALDAAEKITGRVLIYGAGMLGIAAAAACAEVGAQVHVHELDPARLELAREFGATPDTGEPMDLVFDFSGSSRAITGALERLGIGGTLVLAGSVTPGPAIGIDPETVVRRWHTITGVHNYEPHHLTQAIDFLERTNTTYAWETVVAQPVPLAEIASLFTSSSPGKLRMSCTP
>NC_018681.1|WP_141692110.1|5741457_5742090_-|TetR/AcrR-family-transcriptional-regulator
MKPAPDGRALRYRHRRPELLRGATEFVLEHGIADLSLRAVAEALDVSHPTLLRHFTSKEALLLAILDALRTDLFAKPADVDALAQAQQTPADLVRALWRKLCEPAEQRQFHLLFQLVSPPGAIVQGSEELATSLVRDWVEMITERLVLDGWPRERAEPVATLVLAQFRGLQLDLLLTGDRERADRAVEESLRLLAPRSEQPGEMMGAPAS
>NC_018681.1|WP_051067007.1|5742260_5743535_+|hydrolase
MSPRNRANTVPFLLRYLARKTLTRRRPASLAAAGLFTGAPQHVTLAGIRELAPTRKMAASKTPFEWPVGATIQLPETYSFGGARWSTEQFLVGTDTAALLVLVEGTVRYERYLLTGGPKVNWLSMSVAKSFVSCLVGIAVDEGLIRGIDDPISDYVRVEPGSAYDGVSIRTVLGMSSGARWNEAYHDRRSEIQQLSRAVLGLQGGLDGFVARMAKQSAPETVCRYNSGETQVLGALIARATGRTVSDYMHEKLVEPLGFESPGYWVTDMRGVEASFAGLNLTARDYAKLGELYRNGGVWQGNRIISEDWVRASTTIDSPIREPGNPILGDHGIDLGYGYQWWIPAGNRGDFSAIGILNQLIYVDPASGTTIVKLSANREYGTSKEERTNRDVENVEFLRAIAAHVGHAARPKKRPSPASARSTT
>NC_018681.1|WP_041564328.1|5743796_5744480_+|ANTAR-domain-containing-protein
MPGPGDEDASAAPGDVDPVGRFRFWFDDQRWEWSAEIWHLFGYEPGEKVPTTELMLSHNHPDDRAAVADALAAAVRDHGAFGSRHRVIDTAGVHHQVLVVADGMFDATGAVVGTEGYFIDLTASLRRNRREILEETLPELVSARADIEQAKGVLILAYGLTPDQAFATLRWRSQETNVKLRVLAARLVAAATALRGGPTALRIQMDHIVLSLHEYLDPPTQDRSHGQ
>NC_018681.1|WP_014985828.1|5744549_5745959_-|threonine/serine-exporter-family-protein
MTTPEQRRNIALLLRGSIYSGVSPVPAATGEQYSPRQVIDFCLDLGEVMLSSGADARSVEVAIVAVSATWNLASVELDFPGSSIHMVHAAADEPTIVGLRAVREMNADLHRLNNVYGVVDDIVGGRADMTRASQRLVEYMRSDPRWPYPVVAAAVGLLGVVVALQAGGTFRSAVGAFVLMFVLMYLGRILGRRYIPGFFVAVAQMTVATMLGSLAMAYSSIDPGEAASMVAACVVLLLPHPWIVATAQDAISGFRSLALVRGLGIGLVVLGMVTGVQAGVTSTRWVHLEVDPSAIHLTGLTLFWALLASAIAAGANAFAQGATARVVPISIAAAVFAQMIVQLCARAHIGLQLSLMLGAAMLGAVGTWTAARLRISPASIIVPAFCGALLPSLAVAHSLLQFIGHTPGSGMSVALSVLTTLAIGAGLVLGDIVATGRARRMVSMRTRIPSANLDTEPQPTADTDRPVEL
>NC_018681.1|WP_041564330.1|5746391_5747096_+|glycosyltransferase
MRPSAVVVVVPVHNEQHLLRRCLASVEVAASNSDVPVRVVVVLDACTDGSARLVPASMDIVEVGARSVGAARAAGFAYAATHFTVPELARVWYSSTDADSVVPPDWFSGQLVHASAADVVLGTVAVGWGEHPAPVRAEFERRYLRHGCPGRGHHGHIHGANLGLRADWYHRVGGFAPLAVHEDVDLVTRLQAAGARVAWVDRPAVTTSDRRDNRVPGGFGGYLTALAGDHPESA
>NC_018681.1|WP_014985830.1|5747095_5748037_+|acyl-CoA-dehydrogenase-family-protein
MGATEAAEFVRDAIDTDAVSKWPLPGSGDTGQRWQALSDLARTDVVIARLTEAHADACAITAELGVGGPRPGQLWGVWAAEPPDPILAAVAREKRVRLSGRKLWCSGAGICTHALVTARVEHASALFAVDLSDPGITVLPGTWHGAGMSRSATLSVEFTDVPATLVAGPGKYVERPGFWHGAIGVAACWLGAAQGVADLLLQTPARADALRLAHRGAVDAALYGAHCALTCAAGEIDADPLDLPSARIRARRVRAVIEDAATRTLDHVGRALGAAPLAHNPAHAQRVADTTVYLRQSHAEHDLADLGALIGAR

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Crispr_ID: NC_018681_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_018681_11

6526340-6526494

Orphan

Consensus_repeat	Method
CCAGTGGCGAACACGGCGCACCGGCCGCTCGGTCTCCGGCCACGCCTCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_018681_11

>merge|NC_018681|11|6526340-6526494|CRISPRCasFinder
CCAGTGGCGAACACGGCGCACCGGCCGCTCGGTCTCCGGCCACGCCTCCCGGACGGACAATCGAGCGGCCCTGCGCCACCAGGCAACCGGTCCTGCGCACCGCACACCAGTGGCGAACACGGCGCACCGGCCGCTCGGTCTCCAGCCACGCCTCC

>NC_018681|11|10|6526340-6526494|CRISPRCasFinder
CCAGTGGCGAACACGGCGCACCGGCCGCTCGGTCTCCGGCCACGCCTCC	CGGACGGACAATCGAGCGGCCCTGCGCCACCAGGCAACCGGTCCTGCGCACCGCACA
CCAGTGGCGAACACGGCGCACCGGCCGCTCGGTCTCCAGCCACGCCTCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_018681.1\|WP_014986543.1\|6532559_6533009_+\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|378915
NC_018681.1\|WP_014986539.1\|6529960_6530347_+\|RidA-family-protein	unknown	unknown	gnl\|CDD\|100004
NC_018681.1\|WP_041562938.1\|6519438_6521067_-\|cutinase-family-protein	unknown	unknown	gnl\|CDD\|366455
NC_018681.1\|WP_141691746.1\|6524118_6525075_-\|alkaline-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|293742
NC_018681.1\|WP_014986542.1\|6532011_6532482_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
NC_018681.1\|WP_014986537.1\|6527624_6528875_-\|adenylosuccinate-synthetase	unknown	unknown	gnl\|CDD\|376374
NC_018681.1\|WP_014986545.1\|6533733_6534099_+\|hypothetical-protein	unknown	unknown	unknown
NC_018681.1\|WP_014986538.1\|6528913_6529861_-\|hypothetical-protein	unknown	unknown	unknown
NC_018681.1\|WP_041564504.1\|6525278_6526037_+\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|225040
NC_018681.1\|WP_014986528.1\|6516510_6516807_-\|hypothetical-protein	unknown	unknown	unknown
NC_018681.1\|WP_051066780.1\|6516858_6517530_-\|hypothetical-protein	unknown	unknown	unknown
NC_018681.1\|WP_014986544.1\|6533018_6533372_+\|MmcQ/YjbR-family-DNA-binding-protein	unknown	unknown	gnl\|CDD\|377256
NC_018681.1\|WP_014986533.1\|6521430_6523818_-\|RelA/SpoT-family-protein	unknown	unknown	gnl\|CDD\|213552
NC_018681.1\|WP_029898632.1\|6516226_6516502_-\|hypothetical-protein	unknown	unknown	unknown
NC_018681.1\|WP_014986540.1\|6530448_6531477_+\|saccharopine-dehydrogenase-NADP-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|225807
NC_018681.1\|WP_014986536.1\|6526563_6527199_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|223979
NC_018681.1\|WP_014986530.1\|6517526_6518405_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223531
NC_018681.1\|WP_041564503.1\|6515612_6516185_-\|hypothetical-protein	unknown	unknown	unknown
NC_018681.1\|WP_014986541.1\|6531526_6532006_+\|YbaK/EbsC-family-protein	unknown	unknown	gnl\|CDD\|239825
NC_018681.1\|WP_014986531.1\|6518421_6519381_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235909

Protein	Function_ID	Function_description	E-value
NC_018681.1\|WP_014986539.1\|6529960_6530347_+\|RidA-family-protein	gnl\|CDD\|100004	cd00448, YjgF_YER057c_UK114_family, YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.	3.09667e-23
NC_018681.1\|WP_041562938.1\|6519438_6521067_-\|cutinase-family-protein	gnl\|CDD\|366455	pfam01083, Cutinase, Cutinase.	8.20874e-11
NC_018681.1\|WP_141691746.1\|6524118_6525075_-\|alkaline-phosphatase-family-protein	gnl\|CDD\|293742	cd16018, Enpp, Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin. Ecto-nucleotide pyrophosphatases/phosphodiesterases (ENPPs) hydrolyze 5'-phosphodiester bonds in nucleotides and their derivatives, resulting in the release of 5'-nucleotide monophosphates. ENPPs have multiple physiological roles, including nucleotide recycling, modulation of purinergic receptor signaling, regulation of extracellular pyrophosphate levels, stimulation of cell motility, and possible roles in regulation of insulin receptor (IR) signaling and activity of ecto-kinases. The eukaryotic ENPP family contains at least five members that have different tissue distribution and physiological roles.	3.45393e-37
NC_018681.1\|WP_014986542.1\|6532011_6532482_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	3.29529e-39
NC_018681.1\|WP_014986537.1\|6527624_6528875_-\|adenylosuccinate-synthetase	gnl\|CDD\|376374	pfam00709, Adenylsucc_synt, Adenylosuccinate synthetase.	2.96732e-92
NC_018681.1\|WP_041564504.1\|6525278_6526037_+\|metallophosphoesterase	gnl\|CDD\|225040	COG2129, COG2129, Predicted phosphoesterases, related to the Icc protein [General function prediction only].	1.73145e-13
NC_018681.1\|WP_014986543.1\|6532559_6533009_+\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|378915	pfam12680, SnoaL_2, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	0.000551877
NC_018681.1\|WP_014986544.1\|6533018_6533372_+\|MmcQ/YjbR-family-DNA-binding-protein	gnl\|CDD\|377256	pfam04237, YjbR, YjbR. YjbR has a CyaY-like fold.	1.3375e-09
NC_018681.1\|WP_014986533.1\|6521430_6523818_-\|RelA/SpoT-family-protein	gnl\|CDD\|213552	TIGR00691, PppGpp_synthetase., (p)ppGpp synthetase, RelA/SpoT family. The functions of E. coli RelA and SpoT differ somewhat. RelA (EC 2.7.6.5) produces pppGpp (or ppGpp) from ATP and GTP (or GDP). SpoT (EC 3.1.7.2) degrades ppGpp, but may also act as a secondary ppGpp synthetase. The two proteins are strongly similar. In many species, a single homolog to SpoT and RelA appears reponsible for both ppGpp synthesis and ppGpp degradation. (p)ppGpp is a regulatory metabolite of the stringent response, but appears also to be involved in antibiotic biosynthesis in some species. [Cellular processes, Adaptations to atypical conditions].	0
NC_018681.1\|WP_014986540.1\|6530448_6531477_+\|saccharopine-dehydrogenase-NADP-binding-domain-containing-protein	gnl\|CDD\|225807	COG3268, COG3268, Uncharacterized conserved protein [Function unknown].	3.66044e-19
NC_018681.1\|WP_014986536.1\|6526563_6527199_-\|NUDIX-hydrolase	gnl\|CDD\|223979	COG1051, COG1051, ADP-ribose pyrophosphatase [Nucleotide transport and metabolism].	4.221e-10
NC_018681.1\|WP_014986530.1\|6517526_6518405_-\|hypothetical-protein	gnl\|CDD\|223531	COG0455, flhG, Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility].	0.00545774
NC_018681.1\|WP_014986541.1\|6531526_6532006_+\|YbaK/EbsC-family-protein	gnl\|CDD\|239825	cd04333, ProX_deacylase, This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro) deacylase and also the cis-acting prolyl-tRNA synthetase-editing domain (ProRS-INS). While ProX and ProRS-INS hydrolyze misacylated Ala-tRNA(Pro), the E. coli YbaK hydrolyzes misacylated Cys-tRNA(Pro). A few CD members are N-terminal, YbaK-ProX-like domains of an uncharacterized protein with a C-terminal, predicted Fe-S protein domain.	1.71986e-60
NC_018681.1\|WP_014986531.1\|6518421_6519381_-\|hypothetical-protein	gnl\|CDD\|235909	PRK07021, fliL, flagellar basal body-associated protein FliL; Reviewed.	0.00722094

>NC_018681.1|WP_041564504.1|6525278_6526037_+|metallophosphoesterase
MPADSARPGVRVAAVADTHLRPAVAGRFRPAFRRLAEQADVLLLAGDLTDGGTLAETDLLCAEIADLPVPVVAVLGNHDHDRRLGYRIAAQLTAAGVHMLDGTAITLELNGFRLGIAGVMGGSGGFPDHPGSPDTGTVEHRERMRRGPLDALRLQQALDTLDTEIRVALMHFAPTLDTLAGEPPKIYPGLGCADLGRAVDAGRATLAVHGHAHAGTEIGCTPGGIPVRNVSYPVLGRPYAVYTLTPHLALES
>NC_018681.1|WP_141691746.1|6524118_6525075_-|alkaline-phosphatase-family-protein
MVRGMRLVAKALAVAAATVLPLTVVAGAAQADTRVDKVVVIGLDGLMFDKVQQVKAPNLLRLSAEGLLSRSSIAPHITISGPSWASVLTGVWDRKHGIEDNNFTAAPFAAYPTVFTQLERADPARKTQSIATWDQIATMTGSGDPRADVVVSTPPVPDDPDEAKTDAATATAVVTAVTKFAPDFLFTHLDQVDHAGHQDGGASDEYLDAVRRIDAQVGRIAAAVDARALANPGERWTILVTADHGHTPKGGHGGQSADETTNFVIARGPDFAAGSTTSRFTLVDITPTVVDLLGVAASPDFDGRSMITRAPTDVATIR
>NC_018681.1|WP_014986533.1|6521430_6523818_-|RelA/SpoT-family-protein
MTQHLGEANVEQSAGAPQSNGAATGGEPPKPGTPARQAGATAAVPTSASRRVRARLARRMTGQRGIAAVKPVLEPLASVHRELYPKANLTLLQRAFDVADERHKHQFRKSGDPYITHPLAVANILAELGMDTTTLVAALLHDTVEDTGYSLEQLTLDFGPEVAHLVDGVTKLDKVNLGAAAEAETIRKMIIAMARDPRVLVIKVADRLHNMRTMRFLPPEKQAKKAKETLEVIAPLAHRLGMATVKWELEDLAFAILHPKKYDEIVRLVADRAPSRDTYLAKVRAEIVNTLAASRINAIVEGRPKHYWSIYQKMIVKGKDFDDIHDLVGIRILCDEVRDCYAAVGVVHSLWQPMAGRFKDYIAQPRYGVYQSLHTTVVGPDGKPLEVQIRTQDMHRTAEFGIAAHWRYKETRGKHSNDSTEVDDMAWMRQLLDWQREAADPAEFLESLRFDLKSPEIFVFTPKGDVITLPQKSTPVDFAYAVHTEVGHKCIGARVNGRLVALERQLENGEVVEVFTSKAQNAGPSRDWQNFVVSPRAKAKIRQWFAKERREEALENGKEQISKEVRRVGLPLQRLMSVDAMTAVAHELHYTDISTLYTAVGEHQVSAHHVVQRLMAQLGGIGDVENELAERSTPSTTPARQRTTGDAGVLIPGAPGTVAKLAKCCTPVPGDEIMGFVTRGGAVSVHRTDCTNAGSLQDQAERIIEVAWAPSPSSVFLVAIQIEALDRTRLLSDVTKVLADEKVNILSASVATHGDRVAISKFTFEMGDPKHLGHLLNVVRNVEGVYDVYRVTSAA
>NC_018681.1|WP_041562938.1|6519438_6521067_-|cutinase-family-protein
MTNYSAGVTGVLTALAVTVATAGIAVADPPKPAGPSTNIALSACPALYALGIQGTGESSPDAAPSTDTGMLSTVFRPMLAKAADAGLVDRAYVPYESSFGGATAGAAVPYSESVTGGLVRLRTMAKNVADRCADTRFAVVGYSQGAHVASVFAQEIGQGNGVLPADKVAAVALFGDPTRNAGAPLFPGSPGKATPDPAPGTAGDQLAELAALPLTPATGGGIGPDRDRAANFGALTGRVASFCAAGDLACDAPQGAPILKAVTNVVGQSKLSGGDPITSLVSIAQALAYTSIKTATKVVNEDVQGNSLATLSLSPKKSISERLADAADPRTPLDLPAALQALLKVGTIGLNAVVTVVKSVLNPAAISELATAGLANPPAALLSLGTKLAGALTQLVPPTTGVRLVNQAFDAVVQNITDNSELLNTTTWVRYWDTVQRHHAYNTATVAANGDTPTTFVADWLAAIARDIAGAFGANGSPRGGADKPPTGFFGEQSGASTTPNSSGTGQFPFGTGADGASSGGATSIPPTDRPGTANTYPFSTN
>NC_018681.1|WP_014986531.1|6518421_6519381_-|hypothetical-protein
MLKSYKDLSRWYGALEPETAPVHRDETDAVQLDDDGPARYPHYIRDEPAPEVPAELAAQRSEFTGGWSDWVGRAPGPDDDYTPRDADLVRFPWPDEDDYGHFDEPRRRPSGALRAQARARGSRRTRVFVVLVIAVLLLGAAAAGVLFLLNSASHRAAPRTPTPAASVQFTAGSVQAGVSTDSLLSRSQAGVSTHRPNGACPTEHAATIVRGAEKGSTATGPDAIMAFQYAYYVERSGERARQAVADDATVSPAATIQRGIDTIPAGTTHCVRIVTIADNRYSVEVTEYRPGGVPATYNKQTVTTAVIDGRTLITGIAAG
>NC_018681.1|WP_014986530.1|6517526_6518405_-|hypothetical-protein
MGEDWSRWLDETPEAGESSGKPGRSKAPVVRLRRGKGGGSGAEQPLQRPILVVGGCGGAGTTTTALGIAGELGMAGTPTVAVDATQAGSDLALRGADEHLHPISLQSWLYGRGDDEPAPLKECLSRATSGIGLLWRDSAPLRRRATYLTVARAVYDSGHTAVYDGGSPIAGRQLRPLLDDADVALVLAIPARADAANRLRVTLEWLDDQFGDSSEGQGGGIVGDTTIVISHQHPGTESRVAEHLREHLSGWVRDIREIPYDPHLARGELVRHASLAIETRRAYGRLLAGVAS
>NC_018681.1|WP_051066780.1|6516858_6517530_-|hypothetical-protein
MTAAMSFRRQQPESAPVGVVAPPESRRAPIWDRPVPGIGRAPLVWLLGVHGGAGASSLAHVLAPAADSSRRWPGVFDRESPFVVLVARETISGLTRAHDLLRQHHSGFAGSCEVLGLITVAARPGRLPAEIRRYRDVVGSLAGQLWQVPWYEEWTLVEPEKLPVWTPGDPMPPKKRKIDPLEEVPLDVRELGADIVAAARTALEEAELDDPARNRGGRKPPDQ
>NC_018681.1|WP_014986528.1|6516510_6516807_-|hypothetical-protein
MSTILLAVQETYGTVLAQVGNPTPEAPPGSEKILQLVRYLTWFVLLSGICGITYAGGKFAWEKWTGGGLESPKMVAGAMIGGVVATSAGTIMNAVIGT
>NC_018681.1|WP_029898632.1|6516226_6516502_-|hypothetical-protein
MGTVRASAVELLAYKQMPSEVLQPLMQLLNWLLWFVLLVCLAWMIVSAGRLWIAFRSDLAMNDASHGVLMSLLGATVASTASGIALAFLPT
>NC_018681.1|WP_041564503.1|6515612_6516185_-|hypothetical-protein
MLLATVGCGGGDEQTGPDLSAPPTGVRWQPFQGVALPHTDQGPESVADGAATGFEHSPRGAGVAAITHAVRLAVAADSQWAKVAARELVPGPAKDEWAINRFQLSITGPAAPEYAPRVLGYKITGYTDERSTVDVHTEYSDSSKAVNHTTVEWFGQDWRLRLPDPGTMARPIDPIDVLPTDTVKLEAPQS
>NC_018681.1|WP_014986536.1|6526563_6527199_-|NUDIX-hydrolase
MEQSVVSVDVVTLRFWGDDAAVRLGVASRALDPFAGELALPGVLLGRGERLAAAARRAVHTKLGVPQAAVGAVGQLVTFDEPNRDPRGPTLSIAMWAVVGPHEGPAHWVEFDGVPELAFDHNRIVEAARGLLAGLLWKDLPFTRALIGDEFPATRAVEATTALAGTRPDPANLNRTLATLPGLARTTERRRVKATGRPAAIWAFDPKPPAE
>NC_018681.1|WP_014986537.1|6527624_6528875_-|adenylosuccinate-synthetase
MFRSHIVVVDLGFGDAGKGATVDWLCSAEAGLDVAAVVRFNGGAQAAHNVIAEGRHHTFAQFGSGTFSGVPTLLSRHMLVEPIALAGEAEQLAVLGVRDPLSLLRIDGRARLTTPIHIAANRAREDARGSSRHGSCGRGIGETAAYALAYAAPTVADCLRPKVLREKLASLAAHYGALIASSEHRYEPIDDLVEMYREFAAAVRIVGGEQLAGFARRGRLVFEGAQGVLLDEWRGFHPHTTWSTVEPRNARALLAEIGATCDVLGVTRTYLTRHGAGPFPTEDAALDLPERHNTTGRYQGEFRRGHLDPILLRYAIAVCGGIDALAVTHLDAPGTRYAATGYRTDRGIRTELPPGDWQDLDHQQRLTDLLTTADPVLTELPADVVPWLERQLGTPVALTSDGPTRAHRTAALAAAA
>NC_018681.1|WP_014986538.1|6528913_6529861_-|hypothetical-protein
MGYGNWDDTAYRAAKTFRASRGLDDFGYTAEMQGVPYDSWQAHPTLDPLGVTVRECRDSADHDNSLPIAVLFDVTGSMGRVPRIMQQKLGTLHGLLQRKGYADDPQILFGAIGDADTDRVPLQVGQFESDNRMDEQLRAILLEGGGGGQKSESYELAAYFMATHIVTDAWEKRGKKGYLFLIGDELNKPKLASRHIRSVIGDSVRRDISVESIYRELAERWHVYYILPNQSNYYDDPEIAEHWRGLLGQHFMKLDEPAAVCELIALTIGVAENRVDVDAGLADLRDVGSAAEAASVGKALAATGPRMRALPSGRR
>NC_018681.1|WP_014986539.1|6529960_6530347_+|RidA-family-protein
MELEPRNPTDGVYAATDDYVHAMEVRGAERLLFISGTMGLDPEGKPGATLAEQLDLIWSNLRAILASAGMTVDNIVRLTSYLRDPAYADANAAARVAALGGRTVPTTAIVVQTLVSEWLVEIEVVAAG
>NC_018681.1|WP_014986540.1|6530448_6531477_+|saccharopine-dehydrogenase-NADP-binding-domain-containing-protein
MSSSVAVFGAYGHTGRFLVAELVRRGWTPILSGRDEVRLRELAGAHAGLEVRPATIDDPAALDRALAGTVAVINAAGPFGDTVPAVVEAALRAGVHYVDVAAEVEVVAKTVATYQDRATAANIVVAPAIAFYGGLGDLLASAAMADLPAADEIELAFALDSWVPTKGTRAAGVASRGRRNGQRLVYRDGAFGLRDDAAPVSERAFPAPFGKQTVVGDFTTADSVTIPYHLKTAALHTYMTAAPLRDLASPDRTPPQPADESGRSAQQFLVEVVVRSGSLRRHAVAAGRDIYAVTAPIAVEALSHITSGGRSGVRTAGQLGDSGAILRALLPAHLDRLEFDAD
>NC_018681.1|WP_014986541.1|6531526_6532006_+|YbaK/EbsC-family-protein
MDEIATKPTVLAVEAALRAAGITPQIRVLPETAPTAVAAAEQLGCPVAAIANSLIFDAAGAPLLVLTSGAHRVDTGKVAAHLGLAKLTRATAEFVRAHTGQAIGGVAPLGHPAPIRTLIDETLAAHDEIWAAAGHPHTVFCTTFPELLEATGAEAISVN
>NC_018681.1|WP_014986542.1|6532011_6532482_-|helix-turn-helix-transcriptional-regulator
MVCSIARTLDVIGERWTPLVLRDLFVGLSRFEDLRRDLGIASNVLAARLATLQAHGIVEAVEYQSNPVRHEYVLTPKGRELYPALTMLVAWGDAWLAGPEGPPALVVHEDCGKVTAGVVVCRECGAELTADNVRFAHGPGAHRGPGTMLIGDHMSP
>NC_018681.1|WP_014986543.1|6532559_6533009_+|nuclear-transport-factor-2-family-protein
MDTAQDQAAATDVVAAFRTATTTADFDTLMDLLTEDAALTSPLSGRMVFRGKDDLRVLLTAAYGGLSGLRWTDEIGDGNRRVLLAEASVGPFRLTEALVLDLADDGRIRGLSPHLRPWLTLTAVAVRLAPGLFKHPGVLRRAMRGAATP
>NC_018681.1|WP_014986544.1|6533018_6533372_+|MmcQ/YjbR-family-DNA-binding-protein
MDPLPRIRAICLDLPECSERLSHGCPTFFVRTKKSFVKYIPSGYDEPGPTIWCPAPEGVQGELVDAEPTRFFVPPYVGHSGWIGVRLDIDPDWNEFTEIIRDAYRRVAPKKLVAELD
>NC_018681.1|WP_014986545.1|6533733_6534099_+|hypothetical-protein
MREQDPTPDEQRFFDALRAQVPEIDDWYHEDKDGTLWVIASLDFGDNTGHIYDTLRVDYDGISLRGGWSPASLNWDDGVRANKAGIDTAPPDGLRRDNIAPLRAAHAAAEWFLAHRERRRR

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Crispr_ID: NC_018681_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_018681_12

6757964-6758086

Orphan

Consensus_repeat	Method
CTCCGCGCCAATCGAATCAGTCCACATGCGGCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_018681_12

>merge|NC_018681|12|6757964-6758086|CRISPRCasFinder
CTCCGCGCCAATCGAATCAGTCCACATGCGGCAGCAGTGCAGCTCCGGCATTCCACGAATCCCATGGAGAGATCGCCTCCCCCATCCACGCTCCGCGCCAATCGAATCGGTCCACATGCGGCA

>NC_018681|12|11|6757964-6758086|CRISPRCasFinder
CTCCGCGCCAATCGAATCAGTCCACATGCGGCA	GCAGTGCAGCTCCGGCATTCCACGAATCCCATGGAGAGATCGCCTCCCCCATCCACG
CTCCGCGCCAATCGAATCGGTCCACATGCGGCA

Protein	Signature genes	Signature genes Name	Protein_function
NC_018681.1\|WP_081594180.1\|6763785_6764961_-\|AraC-family-transcriptional-regulator-ligand-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|378890
NC_018681.1\|WP_014986759.1\|6765108_6765837_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|181136
NC_018681.1\|WP_014986757.1\|6763023_6763701_-\|DUF5134-domain-containing-protein	unknown	unknown	gnl\|CDD\|375044
NC_018681.1\|WP_014986742.1\|6748739_6749687_+\|PAC2-family-protein	unknown	unknown	gnl\|CDD\|378251
NC_018681.1\|WP_014986755.1\|6761572_6762277_-\|anti-sigma-factor	unknown	unknown	gnl\|CDD\|378389
NC_018681.1\|WP_014986753.1\|6760069_6760609_+\|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|129859
NC_018681.1\|WP_014986744.1\|6752393_6753506_+\|type-III-PLP-dependent-enzyme	unknown	unknown	gnl\|CDD\|143482
NC_018681.1\|WP_041562959.1\|6755819_6756410_-\|TetR-family-transcriptional-regulator-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|379901
NC_018681.1\|WP_051066789.1\|6755008_6755755_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235975
NC_018681.1\|WP_014986743.1\|6749722_6752221_+\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|378795
NC_018681.1\|WP_141692228.1\|6745693_6746749_-\|DUF4192-domain-containing-protein	unknown	unknown	gnl\|CDD\|379390
NC_018681.1\|WP_141692224.1\|6756556_6757603_+\|DUF559-domain-containing-protein	unknown	unknown	gnl\|CDD\|380141
NC_018681.1\|WP_014986745.1\|6753544_6754747_+\|adenosylmethionine-decarboxylase	unknown	unknown	gnl\|CDD\|376892
NC_018681.1\|WP_014986746.1\|6754805_6755009_-\|4-oxalocrotonate-tautomerase-family-protein	unknown	unknown	gnl\|CDD\|224853
NC_018681.1\|WP_014986752.1\|6759427_6760015_+\|peroxiredoxin	unknown	unknown	gnl\|CDD\|239313
NC_018681.1\|WP_014986756.1\|6762269_6762974_-\|ECF-RNA-polymerase-sigma-factor-SigK	unknown	unknown	gnl\|CDD\|182015
NC_018681.1\|WP_014986760.1\|6765843_6767475_-\|acyl-CoA-synthetase	unknown	unknown	gnl\|CDD\|236097
NC_018681.1\|WP_063632366.1\|6747793_6748459_-\|hypothetical-protein	unknown	unknown	unknown
NC_018681.1\|WP_014986751.1\|6758394_6759303_-\|hydrogen-peroxide-inducible-genes-activator	unknown	unknown	gnl\|CDD\|176103
NC_018681.1\|WP_041562960.1\|6760758_6761433_+\|PhzF-family-phenazine-biosynthesis-protein	unknown	unknown	gnl\|CDD\|223461

Protein	Function_ID	Function_description	E-value
NC_018681.1\|WP_081594180.1\|6763785_6764961_-\|AraC-family-transcriptional-regulator-ligand-binding-domain-containing-protein	gnl\|CDD\|378890	pfam12625, Arabinose_bd, Arabinose-binding domain of AraC transcription regulator, N-term. AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].	8.87113e-24
NC_018681.1\|WP_014986759.1\|6765108_6765837_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|181136	PRK07825, PRK07825, short chain dehydrogenase; Provisional.	1.03023e-59
NC_018681.1\|WP_014986757.1\|6763023_6763701_-\|DUF5134-domain-containing-protein	gnl\|CDD\|375044	pfam17197, DUF5134, Domain of unknown function (DUF5134). Proteins in this family are uncharacterized, but have been identified as members of a gene cluster for the synthesis of the tetramic-acid antibiotic streptolydigin, which inhibits bacterial RNA polymerase (RNAP).	1.32008e-05
NC_018681.1\|WP_014986752.1\|6759427_6760015_+\|peroxiredoxin	gnl\|CDD\|239313	cd03015, PRX_Typ2cys, Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. The functional unit of typical 2-cys PRX is a homodimer. A unique intermolecular redox-active disulfide center is utilized for its activity. Upon reaction with peroxides, its peroxidatic cysteine is oxidized into a sulfenic acid intermediate which is resolved by bonding with the resolving cysteine from the other subunit of the homodimer. This intermolecular disulfide bond is then reduced by thioredoxin, tryparedoxin or AhpF. Typical 2-cys PRXs, like 1-cys PRXs, form decamers which are stabilized by reduction of the active site cysteine. Typical 2-cys PRX interacts through beta strands at one edge of the monomer (B-type interface) to form the functional homodimer, and uses an A-type interface (similar to the dimeric interface in atypical 2-cys PRX and PRX5) at the opposite end of the monomer to form the stable decameric (pentamer of dimers) structure.	1.87947e-80
NC_018681.1\|WP_014986755.1\|6761572_6762277_-\|anti-sigma-factor	gnl\|CDD\|378389	pfam10099, RskA, Anti-sigma-K factor rskA. This domain, formerly known as DUF2337, is the anti-sigma-K factor, RskA. In Mycobacterium tuberculosis the protein positively regulates expression of the antigenic proteins MPB70 and MPB83.	7.32036e-18
NC_018681.1\|WP_014986753.1\|6760069_6760609_+\|carboxymuconolactone-decarboxylase-family-protein	gnl\|CDD\|129859	TIGR00777, AhpD_protein., alkylhydroperoxidase, AhpD family. Members of this family are alkylhydroperoxidases, which catalyze the reduction of peroxides to their corresponding alcohols via oxidation of cysteine residues. In these alkylhydroperoxidases, the cysteines are located in a conserved -CXXC- motif located towards the COOH terminus. In Mycobacterium tuberculosis, two non-homologous alkylhydroperoxidases, AhpD and AhpC, are found in the same operon. [Cellular processes, Detoxification].	4.51191e-74
NC_018681.1\|WP_014986744.1\|6752393_6753506_+\|type-III-PLP-dependent-enzyme	gnl\|CDD\|143482	cd00622, PLPDE_III_ODC, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase. This subfamily is composed mainly of eukaryotic ornithine decarboxylases (ODC, EC 4.1.1.17) and ODC-like enzymes from prokaryotes represented by Vibrio vulnificus LysineOrnithine decarboxylase. These are fold type III PLP-dependent enzymes that differ from most bacterial ODCs which are fold type I PLP-dependent enzymes. ODC participates in the formation of putrescine by catalyzing the decarboxylation of ornithine, the first step in polyamine biosynthesis. Members of this subfamily contain an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain, similar to bacterial alanine racemases. They exist as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. Homodimer formation and the presence of the PLP cofactor are required for catalytic activity. Also members of this subfamily are proteins with homology to ODC but do not possess any catalytic activity, the Antizyme inhibitor (AZI) and ODC-paralogue (ODC-p). AZI binds to the regulatory protein Antizyme with a higher affinity than ODC and prevents ODC degradation. ODC-p is a novel ODC-like protein, present only in mammals, that is specifically exressed in the brain and testes. ODC-p may function as a tissue-specific antizyme inhibitory protein.	1.70842e-150
NC_018681.1\|WP_041562959.1\|6755819_6756410_-\|TetR-family-transcriptional-regulator-C-terminal-domain-containing-protein	gnl\|CDD\|379901	pfam16925, TetR_C_13, Bacterial transcriptional repressor C-terminal.	1.1951e-24
NC_018681.1\|WP_051066789.1\|6755008_6755755_-\|SDR-family-oxidoreductase	gnl\|CDD\|235975	PRK07231, FabG-like, SDR family oxidoreductase.	2.17886e-64
NC_018681.1\|WP_014986743.1\|6749722_6752221_+\|DEAD/DEAH-box-helicase	gnl\|CDD\|378795	pfam12029, DUF3516, Domain of unknown function (DUF3516). This presumed domain is functionally uncharacterized. This domain is found in bacteria. This domain is typically between 460 to 473 amino acids in length. This domain is found associated with pfam00270, pfam00271.	0
NC_018681.1\|WP_141692228.1\|6745693_6746749_-\|DUF4192-domain-containing-protein	gnl\|CDD\|379390	pfam13830, DUF4192, Domain of unknown function (DUF4192).	4.7753e-58
NC_018681.1\|WP_141692224.1\|6756556_6757603_+\|DUF559-domain-containing-protein	gnl\|CDD\|380141	pfam18741, MTES_1575, REase_MTES_1575. Vsr REase Fold. Fused to HEPN (SWT1/Abi2 family), along with Transglutaminase and wHTH.	2.87092e-07
NC_018681.1\|WP_014986745.1\|6753544_6754747_+\|adenosylmethionine-decarboxylase	gnl\|CDD\|376892	pfam02675, AdoMet_dc, S-adenosylmethionine decarboxylase. This family contains several S-adenosylmethionine decarboxylase proteins from bacterial and archaebacterial species. S-adenosylmethionine decarboxylase (AdoMetDC), a key enzyme in the biosynthesis of spermidine and spermine, is first synthesized as a proenzyme, which is cleaved post translationally to form alpha and beta subunits. The alpha subunit contains a covalently bound pyruvoyl group derived from serine that is essential for activity.	5.2121e-34
NC_018681.1\|WP_014986746.1\|6754805_6755009_-\|4-oxalocrotonate-tautomerase-family-protein	gnl\|CDD\|224853	COG1942, COG1942, Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only].	1.65071e-23
NC_018681.1\|WP_014986756.1\|6762269_6762974_-\|ECF-RNA-polymerase-sigma-factor-SigK	gnl\|CDD\|182015	PRK09646, PRK09646, ECF RNA polymerase sigma factor SigK.	2.9802e-79
NC_018681.1\|WP_014986760.1\|6765843_6767475_-\|acyl-CoA-synthetase	gnl\|CDD\|236097	PRK07788, PRK07788, acyl-CoA synthetase; Validated.	0
NC_018681.1\|WP_014986742.1\|6748739_6749687_+\|PAC2-family-protein	gnl\|CDD\|378251	pfam09754, PAC2, PAC2 family. This PAC2 (Proteasome assembly chaperone) family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 247 and 307 amino acids in length. These proteins function as a chaperone for the 26S proteasome. The 26S proteasome mediates ubiquitin-dependent proteolysis in eukaryotic cells. A number of studies including very recent ones have revealed that assembly of its 20S catalytic core particle is an ordered process that involves several conserved proteasome assembly chaperones (PACs). Two heterodimeric chaperones, PAC1-PAC2 and PAC3-PAC4, promote the assembly of rings composed of seven alpha subunits.	1.17757e-51
NC_018681.1\|WP_014986751.1\|6758394_6759303_-\|hydrogen-peroxide-inducible-genes-activator	gnl\|CDD\|176103	cd08411, PBP2_OxyR, The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily. OxyR senses hydrogen peroxide and is activated through the formation of an intramolecular disulfide bond. The OxyR activation induces the transcription of genes necessary for the bacterial defense against oxidative stress. The OxyR of LysR-type transcriptional regulator family is composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The C-terminal domain also contains the redox-active cysteines that mediate the redox-dependent conformational switch. Thus, the interaction between the OxyR-tetramer and DNA is notably different between the oxidized and reduced forms. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.26832e-82
NC_018681.1\|WP_041562960.1\|6760758_6761433_+\|PhzF-family-phenazine-biosynthesis-protein	gnl\|CDD\|223461	COG0384, COG0384, Predicted epimerase, PhzC/PhzF homolog [General function prediction only].	7.39943e-35

>NC_018681.1|WP_141692224.1|6756556_6757603_+|DUF559-domain-containing-protein
MGALDEPFPGSWALAAGLISRWELRHNFVRVFPDVYIPKGCTLDAAGRARAAAHWAKGSGTLIGLSAAALHGALWLDPHEPAEIARPTHCKPPTGIRAVRTVLDPAECCEIDGFQLTTPARTAFDIGRGSSRDHAVPLLDSLCRATGVTPSEVESMVRAHPGVRGAARLPQILGLLDGGAESPPESHTRMLLIDAGLPRPTTQLVVRDPYGSFVARVDMGWEPWHVAVEYDGTQHWTDPAQRTKDIDRIATLESLGWRVVRVNATLLRHRPHVISDRVCAALRSHGWTNDQGELVAASPESSPPPVPPDRSSSIARHQARVCTTKEARWVRAKVGASQLSCATGPVHR
>NC_018681.1|WP_041562959.1|6755819_6756410_-|TetR-family-transcriptional-regulator-C-terminal-domain-containing-protein
MARPRRSGDTRQLLVEEGAAGFLSSGYHGTGIKQVLDKVGVPKGSFYNYFDSKESFGRAVIEHHSLCVQRNLTEAFGAAPDPISGLRAFFGRLMDEFVAADFTGGCLIANLGGELEGSELLRESLSNAWGAWRDRVAEQLRAAQAAGQIRADIDATELADLLLESWEGAVIRMKIDRTLDPLHKCLNRLLDDYFRP
>NC_018681.1|WP_051066789.1|6755008_6755755_-|SDR-family-oxidoreductase
MRKNMTKTVIVTGSSSGIGQDIARAFVARGDNVVLNGRDADKLAEVAASLGAPANVATVAGNIGSPATGSALVRTAVDRFGGVDVLVNNAGIFGATPFVDVTEAELDSYLDGNLKGTYFTTQAVVRRLREQQTGGSIVNIGTVLVEHALAGLPASAALVSKGGVHALTTSLAAELAADRIRVNAVAPGVIRTPLFGDGDESASARLALLNRIGEVAETTAAVLYLADAEFTTGHIFPVDGGYLSGRAA
>NC_018681.1|WP_014986746.1|6754805_6755009_-|4-oxalocrotonate-tautomerase-family-protein
MPYVNIKVTDEGVTREQKSRLIAGVTELLRDVLGKDPATTFVVIDEVALANWGVGGVDVEEYRRSRF
>NC_018681.1|WP_014986745.1|6753544_6754747_+|adenosylmethionine-decarboxylase
MTADFTGWHVLAEFGGVDAALCDDLEQLESALRESLIAAGVTICDVVHKKFDPQGVTVLALLSESHASIHTYPESGDIFVDVFTCGSIGAGASKAVELLRDKLSPKDVRMQVIRRGHGSQRIEEPVGAGLTRIWDLHEVIVDTRTPFQHMVIARTEQGISLFSDDDRQSTEFSQLTYHEAMMVPAFVLAEKLDKVLIIGSGEGVASQMSVAAGATLVDHVDIDQLEVELCAEHLPYGYTGDELAAAVKGEGPVKVHYADGWDFLADAAQAGTRYDVIVIDLPDERVEDAQHNRLYESEFLSRCRALLAPGGVLTAQAGCATMWRNETLKRSWARFHEQFGTVVQYGSDEHEWTFLFGLNERIDDPVQGMTDRLVTLPYRPETIDARALVRGAIEPHALRV
>NC_018681.1|WP_014986744.1|6752393_6753506_+|type-III-PLP-dependent-enzyme
MPESPFLVIYPERVRENYRALRAAMPAARIRFAVKASPVPELIHVLDEEGAEFDVASIGEIELCLALGVEPQTLCYGNPIKKAADIARAYALGVRRYAFDTEDDLLRIGQHAPGAEVECRFLASAPESRTPFGTKFGCAPGEALRLLVRARDLGLTVAGPYFHVGSQQLDPNAWRIGVEQAGHIVQALADKDIHVSSVNIGGGLPIAYADPAPALDEIASVVGAAVAEYLPATAGLVVEPGRALVGSAGVIHAEVVGVRIAPDGRRWVYLDIGRYNGMAETENEYIAYRFVTDRDGDPVDEAVVAGPTCDGDDVLYQRTRVLLPTTLRAGDRIQILDTGAYTASYSSVSFNGFPPLTVHVSGAEPTRPAG
>NC_018681.1|WP_014986743.1|6749722_6752221_+|DEAD/DEAH-box-helicase
MDLTELLEIPGTDADALYESFGAWAAEQGTPLYPAQDEALLELASGSNVILATPTGSGKSLVAVGAHLIALTQGKRTYYTAPIKALVSEKFFALCDVFGAERVGMVTGDAAVNADAPIICATAEILANLALREGAAADVGQVVMDEFHFYADPDRGWAWQVPLLELPRAQFLLMSATLGEVDFFAKDLERRTGRSTAVVAGTERPVPLTFSYARTPITETLEELVTTHQAPVYVVHFTQAAALERAQALTSVNFATRAEKDAIATALGEFRFASGFGKTLSRLIRHGIGVHHAGMLPKYRRLVERLAQEGLLKVVCGTDTLGVGINVPIRTVLLTGLTKYDGVRTRRLKAREFHQIAGRAGRAGYDTMGTVVVQAPEHEVENTRLLAKAGDDPKKQRKVVRRKPPEGFVSWSEETFDRLIAAQPEPMVSRFTVTNSLLLNVIARPGNCFDAMRHLLEDNHEPRPAQRKHILRAIRLYRALRDAGVVQQLDEPDAQGRRARLTVDLQRDFALDQPLSPFALAAFDLLDKDAPGYTLDVVSLIESTLEDPRQLLMAQQHKARGVAINEMKADGIEYDERMELLEEVTWPKPLAELIEPAFETYRAGHPWVSEFAPSPKSVVRDMIERSMTFAELISFYELARSEGVVLRYLADAYRALRRTVPDAARTEELEDITEWLGELVRQVDSSLLDEWEQLTNPGAETDAEQLAFGAETVRPISANERAFRVMIRNAMFRRVELAALRRWDLLDELGTGPDWAAELAPYFAEYERIGTGPDARGPQLFQIERRPGFWQVRQVLDDPAGDHGWSIVALVDLAESDAAGEIVFDELTVSAG
>NC_018681.1|WP_014986742.1|6748739_6749687_+|PAC2-family-protein
MEHESRMYELEFPAPQLSSDDGAGPVLVHGLEGFTDAGHAVRLATTHLRESLESELVASFDVDELLDYRSRRPLMTFKTDHFSEYAEPELNLWALRDTAGTPFLLLAGIEPDLRWEKFTTAVRLLAEQLGVRRSIGLSAIPMAIPHTRPLGVTAHSSDRDLIPEHQRWPGELQVPGSASSLLEYRMAQHGHESVGFSVHVPHYLAQTAYPEAAQTLLENVADNAGLDIPLAALGEAAARVREQVNEHIAGNSEVETVVHALERQYDSFVSAQERQSSLLVGDGELPSGDELGAEFERFLAEQGGYEGGPETDEQR
>NC_018681.1|WP_063632366.1|6747793_6748459_-|hypothetical-protein
MPAACAVLLAGCGSSVTGHPVSAEQTSVTRQISGPLAALLPEPAQFPQRYPAVVLPPEAAAQAAGDLTGVGRGAAVQPPECAPPEPKFGADQRAVAVGTDDATRATVTVELARTRQPLAALRSQLMQCRSMRVNQSGAGTTVTTELVAAPASEAEDALGLRRTVLPDVAGAGLTQTMRAVTGQIGDVRITVTYLSFSASEPDTAAVNELFVTTAHRVEQGS
>NC_018681.1|WP_141692228.1|6745693_6746749_-|DUF4192-domain-containing-protein
MIGFAPERSLVVLVLRAVPDRDDGAIIDAVMRFDLDQEGGRGRLRAEQVARCVAQVSAHDDVAEVLAVVVDDRSVEPDQCGSDIVERCGIGRFDMLVAALARRLAAQDIALAGAWAVRAIRPGERWWSLFGMQRSGLLADPATSAVALSQVLDGRPVLGSRAELVALVTEDVALQEEVAALLDTALAIARDRYARAVRRGEPDAYSRQALEYVLWQVANLESDNEPMARELAELAAALRDRSVRDAMFALAVGDHAAAAEALWAVLTRALRGRDRAEAAALLGYSAYARGDGPLAGIALEAALTADPDHPMALLLETSLSLGMRPEQMRRLARSGYHAAADLGIDLGEPPM
>NC_018681.1|WP_014986751.1|6758394_6759303_-|hydrogen-peroxide-inducible-genes-activator
MTDQTYQPTLSQLRAFVAVAEYRHFGTAAARLRVSQPTLSQALAALEHGLGLQLIERSTRRVLVTAAGMRLLPKAMATLEAADRFVASATGGGLGGSLRMGIIPTVAPYVLPGLLPELRKKLPALHPQVIEDQTARLLDGLRTGVLDVALLALPADLPGLVEIPLYTEEFVLVTPRGHELAGRTDLVPSVLDSLPLLLLDEGHCLRDQTLDVCRSAEIHPAAVGDTRAASLATVVQCVAGGLGVTLIPEMAVAAETARGTLDTAHFATPAPGRTIGLAYRTSTARADDYEYLAAIIRTQRPA
>NC_018681.1|WP_014986752.1|6759427_6760015_+|peroxiredoxin
MALLTIGDQFPAYNLTAVIGGDLSKVDAQQPDDYFTTITSDDHAGKWRIVFFWPKDFTFVCPTEIAAFGKLNEEFADRDAQVLGASVDNEFVHFQWRAQHEDLKTLPFPILSDLKRELATATGVLNADGVADRATFIVDPNNEVQFVSVTAGSVGRNVDEVLRVLDALQSDELCACNWKKGDPTINAGELLAASV
>NC_018681.1|WP_014986753.1|6760069_6760609_+|carboxymuconolactone-decarboxylase-family-protein
MSIENLKNSLPEYAKDLKLNLSSLARTTVLNEQQLWGTLLASAAATRSATTLREIAEEAADVLSEQAYNAALGAASIMGMNNVFYRGKAFLDGRYDDLRAGLRMQIIGTPGVDKADFELWSFAVSSINGCQHCLEAHEHTLREAGVSREVIFESLRAAAIVAGVAQAVQSTEALAGATV
>NC_018681.1|WP_041562960.1|6760758_6761433_+|PhzF-family-phenazine-biosynthesis-protein
MGTQVDVVRVFTDSAGRFGNELGIARAADMAATEHQALAAKAGYSETVVVEDAVNGVARMRIYTPTVELPFAGHPSVGTAWWFAEHHTPIERLEVPAGPVAVELAEGLTWITARAAWTPNFTFHELPDAEELAALRPDDFTGGPHYLWTWTDQNRGTLRSRMFAPTLGIAEDEATGAAAVAITAQLRRSLIITQGQGSQLFTGWDSDGWVRLGGRVVADQAVEI
>NC_018681.1|WP_014986755.1|6761572_6762277_-|anti-sigma-factor
MAEVPPRSDAELLDLAYPCALDAVAEIERRHIEERLEAADPAVRQAFLDTVWRMREVMARVAALDAQEPPPELEARILAALPPDERSGPPARWSRRLRWAVPVAAAACLVIGGVVVADRINDTPSQVPSAEQTTRTLAGPVTGGGSLVVEISPQQRVARVAFDGVAQPPADHVYQVWLLAGTQPRSAGVLAELPSATKPFVTAFAPGEQLAISVEPLGGSPAPTTSPIAGVVLP
>NC_018681.1|WP_014986756.1|6762269_6762974_-|ECF-RNA-polymerase-sigma-factor-SigK
MQAGDSAIGKPGSAPWYRFGDPVPDGIGEDAAIVACPRPSAAARQRSALVSRELTALLAAIGSGDRAAFTEFYRRTSARVFGLAVRILRSHATAEEVAQEVYLQVWSHAARYDPKLSSPIGWLMMLAHRRAVDRVRAEAAAAGRDLAFAHAHAGRDHDVVAESVTQRMEEQTVADCLDTLTPTQREAIALAYYSGRTYREVADHLSVPLPTVKTRIRDGLKRLEKCLSGEGADG
>NC_018681.1|WP_014986757.1|6763023_6763701_-|DUF5134-domain-containing-protein
MAQFVQQYAALRWAVVAAFLITAGIVVGRMVAPVAVPEHGREHGASGPVPRGGYAESDAAHLIMCLVMLAMLMFPADANPIALRSVLTALTVVFAALLLARLAEPRTGEQRSPATDRLVPLGYHTVTAAAMLYAMSGHIPAGHADGPAPVPALVLAGLFAADALVVTVLGTFGRPGVDTPGYLGIVLRSGGCVAVLAGPRRRWAMVPHVVMDLGTAYMLIAAVSS
>NC_018681.1|WP_081594180.1|6763785_6764961_-|AraC-family-transcriptional-regulator-ligand-binding-domain-containing-protein
MRPLVVRIQNRSAGFVAGNQCPWGSGTYDLRPKTLRISAIASNDGYVASWEWRRSVTHAVILVELGEDHGLTQSQCLHGTEVDPRLLKTPGAEITAAQELGIVRNIVTQLGDPPGLGLEAGSRTHITTLGVFALAVLSSPTMGQAIDVAMRYFSLMTSFARAWHVYRDDEIWLYGDDRDLPADLRAFLAERDVSALLTNWFLVFGVPPPVLRAEIAGGLGPRLAPILEQFEIPSTESAELQLAVFDAADVDAPMPQASPLTAQLFEEQCDELLQRRGLRQGVAGSVRSVLMHRMNGRLSQEEVAAGLHMSLRTMRRRLADEGTSYRRLCAETFGTLAEELLATGLTVEDVAYRMGYSGAPSFSNAFKQWRGVSPGRFARTAADRYRTSVTH
>NC_018681.1|WP_014986759.1|6765108_6765837_+|SDR-family-NAD(P)-dependent-oxidoreductase
MSRKTLAGKRIAITGGAHGIGRETALAFLAEGADVVIGDMDVGSVRAVADQLARTHGGTVVGLALDVTDSARFASFLGSAERKLGGLDVVVNAADVMPSGPFLAETEAESDHQIDINLRAVITGTRLAAERFAARGHGQIVNIGTAAGVTGALGVAVYCATKHGVVGLGAALDHELAERGVTVSTVAAGSITDPVAVADAVVEAVVRQRGGLISVAAPRGLRALRPPSELLRRLFARDGQAH
>NC_018681.1|WP_014986760.1|6765843_6767475_-|acyl-CoA-synthetase
MKLAEVATQAAAVARRAVDETYYATLAVRAGLVTPEWPDRLARMGAAVYRSGLLGGLTGVAAVRYRDRAALIDELGTLTFRELDERTTALANAWRVRGLRDGETVAILARNHRGFHYAVFAAAKCGARIVLLNTDFAGPQLREVVAREGADLLVFDEEYTEILGDLTAPRGRFRAWAEEAGVGTLENLIAGAPRTPLRRATTTAKVILLTSGTTGTPKGAPRRDPTSLAPLGALLDKVPFRAKEITECPAPLFHTLGFAHVALALGFGSTLVLRRRFDPQAVLDSMHRHRATSLIAVPVMLQRLVDLGPQARAGHDFSALRIIFVAGSQLGADLCTRVTDAFGPVIYNLYGSTEVAYATIATPADLAVEPGCVGSPVSSATVKILDDDGNELPPGHTGRIFVGNNFQFEGYTGGGDKARVGKLMSSGDVGHFDSAGRLFIDGRDDDMIVSGGENVFPGEVEELLAAHPAVAEVSAFGVPDERHGQRLRAVLVVREGHSLAEDEVREHVKAHLARFKVPRDVLFVDELPRNPTGKVLKRVLREL

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_018681_1	1.1\|317628\|30\|NC_018681\|PILER-CR	317628-317657	30	MT708545	Rhizobium phage Pasto, complete genome	18950-18979	5	0.833
NC_018681_1	1.1\|317628\|30\|NC_018681\|PILER-CR	317628-317657	30	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	372641-372670	7	0.767
NC_018681_1	1.1\|317628\|30\|NC_018681\|PILER-CR	317628-317657	30	AP014720	Arthrobacter sp. Hiyo8 plasmid pHiyo8-1 DNA, complete genome, strain: Hiyo8	45617-45646	9	0.7
NC_018681_9	9.1\|4372073\|35\|NC_018681\|CRISPRCasFinder	4372073-4372107	35	NC_016626	Burkholderia sp. YI23 plasmid byi_1p, complete sequence	1801512-1801546	9	0.743

1. spacer 1.1|317628|30|NC_018681|PILER-CR matches to MT708545 (Rhizobium phage Pasto, complete genome) position: , mismatch: 5, identity: 0.833

ccgaca-tcagccccgcagggtgcgccgact	CRISPR spacer
-cggcattcagccccgtagggtgagccgacc	Protospacer
 **.** *********.****** ******.

2. spacer 1.1|317628|30|NC_018681|PILER-CR matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 7, identity: 0.767

ccgacatcagccccgcagggtgcgccgact	CRISPR spacer
cgaccaccagccccgcagggcgcgccgcgt	Protospacer
* . **.*************.******  *

3. spacer 1.1|317628|30|NC_018681|PILER-CR matches to AP014720 (Arthrobacter sp. Hiyo8 plasmid pHiyo8-1 DNA, complete genome, strain: Hiyo8) position: , mismatch: 9, identity: 0.7

ccgacatcagccccgcagggtgcgccgact	CRISPR spacer
gactcatcagccgcgcagggtgcgacgcgc	Protospacer
    ******** *********** **  .

4. spacer 9.1|4372073|35|NC_018681|CRISPRCasFinder matches to NC_016626 (Burkholderia sp. YI23 plasmid byi_1p, complete sequence) position: , mismatch: 9, identity: 0.743

ttgccgaacgtgtcgtcggcgccgaacgtgcgggt	CRISPR spacer
ttgccgaacgtgtcgtcgccgctgagcacctgcat	Protospacer
****************** ***.**.*.. .* .*

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage