CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_016011	Listeria ivanovii subsp. ivanovii PAM 55, complete genome	5 crisprs	DinG,cas3,WYL,cas6,cas8b2,cas7,cas5,cas4,cas1,cas2,DEDDh,csa3	0	2	5	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_016011_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016011_1

451361-451647

Unclear

I-A

Consensus_repeat	Method
GTTTTAATTACTTATTGTGAAATGTAAAT	PILER-CR
GTTTTAATTACTTATTGTGAAATGTAAAT	CRISPRCasFinder
GTTTTAATTACTTATTNTGAAATGTAAAT	CRT

4 spacers

The CRISPR arrays of NC_016011_1

>merge|NC_016011|1|451361-451647|PILER-CR,CRISPRCasFinder,CRT
GTTTTAATTACTTATTGTGAAATGTAAATCTGTATAAATTTCATCCGATGAATTTCGACATCGTGTTTTAATTACTTATTGTGAAATGTAAATAAATCGTTGTGAGATAATTATTTCAGATTGAGAATTGTTTTAATTACTTATTGTGAAATGTAAATGTGATAGAAATGTGAGGACTATCCGTTGCCACGCCAGTTTTAATTACTTATTATGAAATGTAAATACATACAAAGCGGTTTGGAAATTTTCTGAACCAACGTTTTAACTACTCATGATGAAAAGTAAAT

>NC_016011|1|1|451361-451583|PILER-CR
GTTTTAATTACTTATTGTGAAATGTAAAT	CTGTATAAATTTCATCCGATGAATTTCGACATCGT
GTTTTAATTACTTATTGTGAAATGTAAAT	AAATCGTTGTGAGATAATTATTTCAGATTGAGAATT
GTTTTAATTACTTATTGTGAAATGTAAAT	GTGATAGAAATGTGAGGACTATCCGTTGCCACGCCA
GTTTTAATTACTTATTATGAAATGTAAAT

>NC_016011|1|1|451361-451647|CRISPRCasFinder
GTTTTAATTACTTATTGTGAAATGTAAAT	CTGTATAAATTTCATCCGATGAATTTCGACATCGT
GTTTTAATTACTTATTGTGAAATGTAAAT	AAATCGTTGTGAGATAATTATTTCAGATTGAGAATT
GTTTTAATTACTTATTGTGAAATGTAAAT	GTGATAGAAATGTGAGGACTATCCGTTGCCACGCCA
GTTTTAATTACTTATTATGAAATGTAAAT	ACATACAAAGCGGTTTGGAAATTTTCTGAACCAAC
GTTTTAACTACTCATGATGAAAAGTAAAT

>NC_016011|1|1|451361-451647|CRT
GTTTTAATTACTTATTGTGAAATGTAAAT	CTGTATAAATTTCATCCGATGAATTTCGACATCGT
GTTTTAATTACTTATTGTGAAATGTAAAT	AAATCGTTGTGAGATAATTATTTCAGATTGAGAATT
GTTTTAATTACTTATTGTGAAATGTAAAT	GTGATAGAAATGTGAGGACTATCCGTTGCCACGCCA
GTTTTAATTACTTATTATGAAATGTAAAT	ACATACAAAGCGGTTTGGAAATTTTCTGAACCAAC
GTTTTAACTACTCATGATGAAAAGTAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_016011.1\|WP_014091930.1\|450170_451106_+\|ribose-phosphate-pyrophosphokinase	unknown	unknown	gnl\|CDD\|234929
NC_016011.1\|WP_003745619.1\|446335_446734_+\|hypothetical-protein	unknown	unknown	unknown
NC_016011.1\|WP_014091937.1\|456645_457458_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|223483
NC_016011.1\|WP_003721293.1\|448453_448747_+\|PTS-sugar-transporter-subunit-IIB	unknown	unknown	gnl\|CDD\|99908
NC_016011.1\|WP_014091931.1\|451725_452313_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|239632
NC_016011.1\|WP_014091935.1\|454277_456089_+\|LapB-repeat-containing-protein	unknown	unknown	gnl\|CDD\|380190
NC_016011.1\|WP_014091934.1\|453448_453907_-\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224759
NC_016011.1\|WP_014091936.1\|456179_456611_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NC_016011.1\|WP_014091940.1\|459095_460535_+\|hypothetical-protein	unknown	unknown	unknown
NC_016011.1\|WP_014091938.1\|457805_458189_+\|hypothetical-protein	unknown	unknown	unknown
NC_016011.1\|WP_014091925.1\|442398_443049_+\|transaldolase	unknown	unknown	gnl\|CDD\|223254
NC_016011.1\|WP_014091932.1\|452383_453064_+\|type-1-glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|153212
NC_016011.1\|WP_014091926.1\|443156_445217_+\|BglG-family-transcription-antiterminator	unknown	unknown	gnl\|CDD\|226234
NC_016011.1\|WP_003745629.1\|448761_450033_+\|PTS-galactitol-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|226298
NC_016011.1\|WP_014091929.1\|447390_448437_+\|galactitol-1-phosphate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|176198
NC_016011.1\|WP_014091933.1\|453082_453442_-\|Lin0512-family-protein	unknown	unknown	gnl\|CDD\|131113
NC_016011.1\|WP_014091927.1\|445850_446318_+\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|238129
NC_016011.1\|WP_014091939.1\|458289_459099_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223550
NC_016011.1\|WP_003745616.1\|445220_445823_+\|SIS-domain-containing-protein	unknown	unknown	gnl\|CDD\|223865
NC_016011.1\|WP_014091928.1\|446744_447386_+\|ribulose-phosphate-3-epimerase	unknown	unknown	gnl\|CDD\|223114

Protein	Function_ID	Function_description	E-value
NC_016011.1\|WP_014091930.1\|450170_451106_+\|ribose-phosphate-pyrophosphokinase	gnl\|CDD\|234929	PRK01259, PRK01259, ribose-phosphate diphosphokinase.	3.51918e-155
NC_016011.1\|WP_014091932.1\|452383_453064_+\|type-1-glutamine-amidotransferase	gnl\|CDD\|153212	cd01741, GATase1_1, Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain. This group contains a subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain. GATase activity catalyses the transfer of ammonia from the amide side chain of glutamine to an acceptor substrate. Glutamine amidotransferases (GATase) includes the triad family of amidotransferases which have a conserved Cys-His-Glu catalytic triad in the glutaminase active site. In this subgroup this triad is conserved. GATase activity can be found in a range of biosynthetic enzymes, including: glutamine amidotransferase, formylglycinamide ribonucleotide, GMP synthetase , anthranilate synthase component II, glutamine-dependent carbamoyl phosphate synthase, cytidine triphosphate synthetase, gamma-glutamyl hydrolase, imidazole glycerol phosphate synthase and, cobyric acid synthase. Glutamine amidotransferase (GATase) domains can occur either as single polypeptides, as in glutamine amidotransferases, or as domains in a much larger multifunctional synthase protein, such as CPSase.	1.59831e-55
NC_016011.1\|WP_014091937.1\|456645_457458_-\|histidine-phosphatase-family-protein	gnl\|CDD\|223483	COG0406, phoE, Broad specificity phosphatase PhoE and related phosphatases [General function prediction only].	8.03215e-47
NC_016011.1\|WP_003721293.1\|448453_448747_+\|PTS-sugar-transporter-subunit-IIB	gnl\|CDD\|99908	cd05566, PTS_IIB_galactitol, PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain that are expressed on three distinct polypeptide chains, in contrast to other PTS sugar transporters. The three genes encoding these subunits (gatA, gatB, and gatC) comprise the gatCBA operon. Galactitol PTS permease takes up exogenous galactitol, releasing the phosphate ester into the cytoplasm in preparation for oxidation and further metabolism via a modified glycolytic pathway called the tagatose-6-phosphate glycolytic pathway. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include galactitol, chitobiose/lichenan, ascorbate, lactose, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.	3.06007e-27
NC_016011.1\|WP_014091931.1\|451725_452313_+\|hypothetical-protein	gnl\|CDD\|239632	cd03577, NTR_TIMP_like, NTR domain, TIMP-like subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by non-covalently binding their active zinc-binding sites. This group contains domains similar to the TIMP NTR domain, which binds MMPs. Members of this group may or may not function as MMP inhibitors.	0.00090237
NC_016011.1\|WP_014091935.1\|454277_456089_+\|LapB-repeat-containing-protein	gnl\|CDD\|380190	NF033186, internalin_K, class 1 internalin InlK. Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface-anchored proteins with an N-terminal signal peptide, leucine-rich repeats, and a C-terminal LPXTG processing and cell surface anchoring site. Members of this family are internalin K (InlK), a virulence factor. See articles PMID:17764999. for a general discussion of internalins, and PMID:21829365, PMID:22082958, and PMID:23958637 for more information about internalin K.	1.36422e-122
NC_016011.1\|WP_014091934.1\|453448_453907_-\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224759	COG1846, MarR, Transcriptional regulators [Transcription].	6.60145e-13
NC_016011.1\|WP_014091936.1\|456179_456611_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	8.50199e-27
NC_016011.1\|WP_014091925.1\|442398_443049_+\|transaldolase	gnl\|CDD\|223254	COG0176, MipB, Transaldolase [Carbohydrate transport and metabolism].	6.02657e-58
NC_016011.1\|WP_014091926.1\|443156_445217_+\|BglG-family-transcription-antiterminator	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	3.69027e-75
NC_016011.1\|WP_003745629.1\|448761_450033_+\|PTS-galactitol-transporter-subunit-IIC	gnl\|CDD\|226298	COG3775, GatC, Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism].	1.69818e-176
NC_016011.1\|WP_014091929.1\|447390_448437_+\|galactitol-1-phosphate-5-dehydrogenase	gnl\|CDD\|176198	cd08236, sugar_DH, NAD(P)-dependent sugar dehydrogenases. This group contains proteins identified as sorbitol dehydrogenases and other sugar dehydrogenases of the medium-chain dehydrogenase/reductase family (MDR), which includes zinc-dependent alcohol dehydrogenase and related proteins. Sorbitol and aldose reductase are NAD(+) binding proteins of the polyol pathway, which interconverts glucose and fructose. Sorbitol dehydrogenase is tetrameric and has a single catalytic zinc per subunit. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Related proteins include threonine dehydrogenase, formaldehyde dehydrogenase, and butanediol dehydrogenase. The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit. Horse liver alcohol dehydrogenase is a dimeric enzyme and each subunit has two domains. The NAD binding domain is in a Rossmann fold and the catalytic domain contains a zinc ion to which substrates bind. There is a cleft between the domains that closes upon formation of the ternary complex.	0
NC_016011.1\|WP_014091933.1\|453082_453442_-\|Lin0512-family-protein	gnl\|CDD\|131113	TIGR02058, lin0512_fam, conserved hypothetical protein. This family consists of few members, broadly distributed. It occurs so far in several Firmicutes (twice in Oceanobacillus), one Cyanobacterium, one alpha Proteobacterium, and (with a long prefix) in plants. The function is unknown. The alignment includes a perfectly conserved motif GxGxDxHG near the N-terminus. [Hypothetical proteins, Conserved].	1.27104e-62
NC_016011.1\|WP_014091927.1\|445850_446318_+\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|238129	cd00211, PTS_IIA_fru, PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.	6.17869e-35
NC_016011.1\|WP_014091939.1\|458289_459099_+\|hypothetical-protein	gnl\|CDD\|223550	COG0474, MgtA, Cation transport ATPase [Inorganic ion transport and metabolism].	0.00941667
NC_016011.1\|WP_003745616.1\|445220_445823_+\|SIS-domain-containing-protein	gnl\|CDD\|223865	COG0794, GutQ, Predicted sugar phosphate isomerase involved in capsule formation [Cell envelope biogenesis, outer membrane].	2.76623e-74
NC_016011.1\|WP_014091928.1\|446744_447386_+\|ribulose-phosphate-3-epimerase	gnl\|CDD\|223114	COG0036, Rpe, Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism].	3.06567e-107

>NC_016011.1|WP_014091930.1|450170_451106_+|ribose-phosphate-pyrophosphokinase
MVRKMKLFSVTSERPLATKIADYLDIPLCEVELQKFSDGEVKINIEESIRGTNAYVVQSMNANVNERLMELLIMVDALKRASVHSINIIMPYYGYARQDRKARSREPITAKLMANLIQRAGADRLITVDLHAAQIQGFFNIPIDHLSAVPLIGDYLIEKYGEEDVVVVAPDHSGVVRARRIADRLDAPIAILNRKPRPHEDEIMSVIGDVKGKVAIVVDDIIDTGVRATTSADVLLEKGAVEVIACATHSVMAGDATERLQNSPIKEIIISDSIDLPEDKQFEKLTTISIGRILGRAIEGVQENRSLHPLF
>NC_016011.1|WP_003745629.1|448761_450033_+|PTS-galactitol-transporter-subunit-IIC
MDIILDFFKYIIGLGVTVMMPIIITILGVIFRKKISVAFKAGLTVGVGFVGLGVITSLMLTTITPVTKALVENYNFKLTATDIGWGVGSSLAWGTEVVPFVFVAIIATNIVMIAFKWTKTMDVDIWNYWQPLFIASALYLTTGSMAIAVFSSIINMAIIFKIADWTQKDVENVLGLEGISLPQIQTTGWALVGYPMNWLIGKIPGVRKINWSTEKVQSRLGIFGEPMLMGLIIGGGLAAIAQMPLSQVLQTGVTIAASLVLIPRMVSLLMDGLTVISEAAHEFMEKRFPGRELFIGLDSAVGIGHPFVLSLGLLMIPITLVLAFILPGNKVLPLADLTALPFYMIFAIVPSKGNLFRGIFTGIVIVIITLYLSGAAAPLMTELAGQIGYNIPKDAVEVTSLAVGTQWYTWIVYYGLHWFGGIL
>NC_016011.1|WP_003721293.1|448453_448747_+|PTS-sugar-transporter-subunit-IIB
MKKKRIYVCCGTGIATSTVISKKVRAVLDEKRIPYEISQCTVQEVASKVSTSKPDIIVSSTTVTGDVGDVPVVIGRSFLTGLKKQETIDEILAILQD
>NC_016011.1|WP_014091929.1|447390_448437_+|galactitol-1-phosphate-5-dehydrogenase
MKALKLYGKRDLRYEEADMPTIENPDEVILKVKTVGICGSDISRYSKLGPYVPGMVWGHEFSGEVIEVGSAVKDITIGDRAAGCPALYCGECEYCKKGEFARCRKLTVIGARHPGAYAEYIKLPAENVVKIPDELDYEAAALVEPSAVVVHGYYHTKLQAGDDVVVVGSGNIGLLAIQWAKIFGARKVIAIDVDDKKLAQAKEVGADVVINSLKEDPLEVVAAHTDDLNADLVVEAAGSPITSAQVFAYAKKGGGVVFLGIPYADVTIERFYFEKIVRSELTVWGSWNAISAPFPGKEWQTTIHFLANKQINIEPMITHRLSLKEGPEVFERIYARNEFFGKVLFFPE
>NC_016011.1|WP_014091928.1|446744_447386_+|ribulose-phosphate-3-epimerase
MAKIVPSVFGADIGRINEQLQVLEKNGIDLLHVDMMDGSFVPNIAFGPDQIKMMKKGTKLQFDVHMMVYEPDRYIPRLVEAGAHMITVHQEATTHLHRTIQLIKSYGVRAGVVLNPGTPPSTLEYVLDDLDCILLMTVNPGLGGQTFFQSSLEKIRKTKAYIGDRPIQIEVDGGVNAELAKECTLAGADLIVVGSYLFEGGIEANLAELAKGV
>NC_016011.1|WP_003745619.1|446335_446734_+|hypothetical-protein
MGNFFASFVNWLIGSPGRFVVQLIENNMLIFMLFAMLYTTTILYAKWTLTYYLPKKMYQLAKMKTWELEELHEAWQTEKKSLPWYILVPSRNEFWVKSAKNAPESTKLLHFSQQKLKLSDKEKLQKIIEIQS
>NC_016011.1|WP_014091927.1|445850_446318_+|PTS-sugar-transporter-subunit-IIA
MDVLEYFKEEMVLFSNEQDKENLLSEMAEQLIQVGAVKPSFKEAVIKREAVFPTGLLTAHAGVAIPHTDSEHVIRPVIAVRILETPVSFIEMASDNEAIEVKVVFMMALKSADEQLDMLQTLIQLIQDEEMMTTLLEAKETTNVLTAIEQFSRNT
>NC_016011.1|WP_003745616.1|445220_445823_+|SIS-domain-containing-protein
MDKQAILENIHSTWREEAEAILRLPEVTNENALIETVEKIANCTGKIVVSGCGTSGVAAKKLVHSFNCIERPAVFLTPSDAVHGTLGVLQQDDILILISKGGNTGELLNLIPACKTKGSTLIGVTENPESVIAKEADIFFPVSVAKEPDPFNMLATASTMTVIASFDAIIVCLMTYMNYTKEQFSVIHPGGAVGNKLLNK
>NC_016011.1|WP_014091926.1|443156_445217_+|BglG-family-transcription-antiterminator
MYLDNRSKTLFQEVIKNPNITNKQLEVKYKLSRYQISYSFQKVNEWLKWKNYPEVKRSKNGKFILEPELTTLFSEKETRDPSVEYLPSENERANLILLMLLTAKEELSLAHFTTKIQVSKNTILRDLKVAQKLLPAETTVTYSRASGYQLAGSEWELRKVLTQVVSSVKEMFRGEHYFLSYSGIEQAQLMEIRRTLEEAEAIMQIKFTYEQIELLPYLLSVMFLRIRDRRLIYTAFQIDEKSLSDTREYHITDILLEKTGPVPEQERLFITLQLLTTNIFSGEILTERLTEDLEKVVLTCLDLFEKKALVSLKNKHILIEKLLLHLKPAYYRIKYQMNLEDNLYEKFNQEFEALNFIVKEAFAPLARFIGHEIPAGEIFFISLFIGSDMIPQNDIYHQQKRAIVLCPSGVTFSKIMENILVKLFPEIHFYPTISVREYAFFKAEVDIVFSSIPLKDAENVFVVQPFISDIEKTQLRQHVLERLFGMSNQLTSMDKIMDIVERNADISDESAIREGIIDILSANTATKENRRVKKVYLHDLITEENIMICDDVKNYQEAIRLASQPLLLQQAITANYVKTMINNHNFYDPYIIIGEDIAIPHAMPNAGVNRLAMSLLVVKNGVYFSETEQVHFIIVIAPVDKEQHIEALYQIVHLAENDTMLANLLKNVTKAKIMQTIDQLIIREDE
>NC_016011.1|WP_014091925.1|442398_443049_+|transaldolase
MHLDSGNLEDIKKIQASSIFKGITTNPSILVKEKCSRKTAITNILQQSNKLVFVQTVGFTYEEILADASALLATFGKERIAIKIPAHEDGIYVIETLKKEDKTIKLLGTAIYSADQAIAAGLAGADFVAPYVNRMSGASINPFKEIAKMRHFFDKQALSTQIMAASFKNAGQVMEAYESGADTVTIPYDIYEQMTNKVLAIEAIHVFNQDATLFES
>NC_016011.1|WP_014091931.1|451725_452313_+|hypothetical-protein
MKKALCPILLLLILLASCSTQDETLSPNTKIHKNSVIRADYKIPQNLAELESDSEDIVQVKLIRNKEIGKGNNSSITEVEIIKNYKGSFEPGDKVDISEPWLLTSGEYQAVENYIALEKGQEYILFLSGGHGTDKVSSITSLGYGKYNKSLQEQKADMNDFNTVGEVQKYDFISGLEAEIIKYQEIKKEMLKTYN
>NC_016011.1|WP_014091932.1|452383_453064_+|type-1-glutamine-amidotransferase
MIIDVLQHVSHEGPGLITKWAKENQHQLRIHCLFSESNHVPTNSEFLIVLGGPMGVNDTAEFPWLKEERNLIKRLINQEKPVFGVCLGAQQIATALESNISINDEKEVGWFPVNRTSTKLPFFPEKLDVFHWHQETFSLPNGATRLFSSEGCVNQGFLYGEKIIGLQFHFEMEKAGIETILQIDEEFITPGKFVQSVAEMRERDVPEDNKQMLEAILDYLVAEKNI
>NC_016011.1|WP_014091933.1|453082_453442_-|Lin0512-family-protein
MEKLLFIQTGFGVDVHGQDITKAAERAVRNAIFTNSMPGIRSQLPDNRLENMVVNIKLALPCDADELDEEVIRAIIPYGTVTIETMPGGMLTTSGIFLEDKADKNDLMYIVNASVETGY
>NC_016011.1|WP_014091934.1|453448_453907_-|winged-helix-turn-helix-transcriptional-regulator
MNNEQSMNQQIALFYFGYKAFTETADLIIAKHSLKRLHHRILFFTARMPGLTINELLTFLEISKQALHQPLAELKERQLLTIEQGTRDKRQRCIFLTTAGKELENELGAAQRKQMAQIFAESTDTNGIHFTDVMTGYAKNRPGAALIKDFKE
>NC_016011.1|WP_014091935.1|454277_456089_+|LapB-repeat-containing-protein
MKRLFKLLLTLACVVSLTYPTLTAFAEENSSGNSVVNIPDTALKTYLNSQLKQASDADITADQMALIKSVTITGTNYTDLTGLEAAVNLNTLNISNTNITTLNPIRTLTTLNYLNVSGDVITDSFFPDLNQLTNLENISISSKNVTHNVFTKFNKLPKLRFLYAQNSMLITDISGLASLENLETLFLQFDGIDDFRPLNDFASFKNGKLKSLAAYGQNMGRTNPRITLKSGKLNYNATDQTLYLPFSMMPNQLTSFDGTVAPFSKSTSASNTYVGFNDVAVASSRLSITDDGITISGVTKEEFDGLTELEYNARFDFPTGSYPTPPSMTSYTISAGTYDQYFDISHTLDLTADESIGYNQYTLATEGQFLKAIHAETDDGTAVQSNFDQVVDFNTPGEYTVTLNAENSAGLKADPLEVKVTIYAKPIIKADSSISYEQKTTKTAEEFLTETHSSVTENAALTSDFNDVVDLNTPGEYTVTLNAENERGQKADPVQIIVTVTAKADPEQPVPPTKEKPTTEKPADNKSVATKEPTKATEKNKKSEESPSNLTTKENTEPTTKEVTKTTEQKLPKTGDAGLGTWPVAFTSIMMGLMAIILLKKRK
>NC_016011.1|WP_014091936.1|456179_456611_+|universal-stress-protein
MDKYNRILVAIDGSEPAKLAFEKGLELALKLDGVLGIASIVDIRAFSPNVSYDGSLEEKAELELKGNVNEYAEEARAKGVKQVETFVAKGNPKILLSTDIPAEFQADLIICGATGMNRVEKLVLGSVSSYIMAHAICDTLIAR
>NC_016011.1|WP_014091937.1|456645_457458_-|histidine-phosphatase-family-protein
MKKNILKAMVMFCALLLIAGCGNDSTTSKADTTEKKDGTVTFYVVRHGKTMLNTTDRVQGWSDAVLTPAGEEVVTSAGKGLKDVDFGAAYSSDSGRAIQTANLILEESAKSSDTKLQTDARFREFNFGSYEGDLNHNMWTDIAKSQGKTLEEWQSAGISPKIFADSVAKLDKTRVKEGENWPAEDYATIQARLKNGITEVAKKESKKGDENVLLVSHGLSIGALLDTIEPGYKLPATGIKNASVTKITYKDGKFKIEDVNDMSYAEKGQE
>NC_016011.1|WP_014091938.1|457805_458189_+|hypothetical-protein
MKKKLLIISGVLIMVLFASVSYVQAGSTYANYSTTVGKFNGNGYTAYQTKKVAGQKANVKSTKTGGYKLNVRTNSAGSNGTWSADFTNSKNIDLSNGHNKGTKTRLHFSNKITTTRDVQASGSWRSN
>NC_016011.1|WP_014091939.1|458289_459099_+|hypothetical-protein
MQSMIKKELKEYITITNILIIIIGSLAPTLYILSQANNQTYLHWLGLYSNSVGSFQALLFPLFIVILTIPKLSTKLSNKFISYVRIRKNIYQYLGATMISNAIIVFVGSFLLVFIPFIITYYIVPIFGLIGYQPESMGLNTVAAINNDIATNDALSFLINVSPLFYAIVYAAWVGFNGILWYIVSWCLLIIKNNIFLALSIPFVVYQIAHFLFSLLGVPQFGSLISIFPFNFEKVPVWNMLLFPMLLIVGVISMLIYIYKNIEKMDSLS
>NC_016011.1|WP_014091940.1|459095_460535_+|hypothetical-protein
MSLAKITNTFINVKNLSIFSIASLYGILALQGSFNQYNMNFAERSVSLLSDPYLFIYFILPIWIMLVSKEILTRKDYQNTIRLKTKQRYNLWLLRKCMLISFSLITVLLISSICISVGGDVKLTWSSHIANYQETGLIVSVLNDLISSPISAILVQLLVYFIFLSTIAYFIITITYKIHTPIFIYCVSLLILIYMMYTFTFAMEPLYMNISSLAFAYRVLGQLSQEIIVYTVILVTCILLNTNKVLRKINDLYMYQKKHIIFLAVILVSYVFLGINGADLSINDYIISTNYGSSNEGYTINSILFYAIIYLGIPYLILLGINEKQQLIYYELIRQKTMNKWIFKNILAALQYSCLYLMVTFLIMIGTSYKNYQELLSIDGEILYQYFINGSLQIFFYSLIILLTYSITGKITYALYLNLGLIILLLPVININHILPIGLNAMGMLEDRTPYQLSLQLLIAILMITMILILVNRKRTIPQ

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Crispr_ID: NC_016011_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016011_2

469832-470314

Unclear

I-A

Consensus_repeat	Method
GTTTTAATTACTTATTATGAAATGTAAAT	PILER-CR
GTTTTAATTACTTATTATGAAATGTAAAT	CRISPRCasFinder
GTTTTAATTACTTATTATGAAATGTAAAT	CRT

7 spacers

cas2,cas1,cas4,cas3,cas5,cas7,cas8b2,cas6

The CRISPR arrays of NC_016011_2

>merge|NC_016011|2|469832-470314|PILER-CR,CRISPRCasFinder,CRT
GTTTTAATTACTTATTATGAAATGTAAATTCAATTCCCTTGTTCGCTATAAACGGATGGAATAAAGTTTTAATTACTTATTATGAAATGTAAATAGCTTCCTTTTTTTAAGAAATTAGCAACATTTTCAGCGTTTTAATTACTTATTATGAAATGTAAATGGAGGAACAGCGACCGGTTTCGGCTCGGATATTAGTTTTAATTACTTATTATGAAATGTAAATTAGCTTTGCATTTTTTCAGTGATAGAAGTCGCATATGTTTTAATTACTTATTATGAAATGTAAATAACGATATTGGTACAAAAGTAAATTTATCGTTTTTGTTTTAATTACTTATTATGAAATGTAAATAATATCATAGATGCGACTACAACGCCGTCTGACACGGTTTTAATTACTTATTATGAAATGTAAATGTCAAATTGCTCATTGAAATAAAGCGGGTTTGTGATTGTTTTAATTACTTATTATAAAATGTAAAT

>NC_016011|2|2|469832-470314|PILER-CR
GTTTTAATTACTTATTATGAAATGTAAAT	TCAATTCCCTTGTTCGCTATAAACGGATGGAATAAA
GTTTTAATTACTTATTATGAAATGTAAAT	AGCTTCCTTTTTTTAAGAAATTAGCAACATTTTCAGC
GTTTTAATTACTTATTATGAAATGTAAAT	GGAGGAACAGCGACCGGTTTCGGCTCGGATATTA
GTTTTAATTACTTATTATGAAATGTAAAT	TAGCTTTGCATTTTTTCAGTGATAGAAGTCGCATAT
GTTTTAATTACTTATTATGAAATGTAAAT	AACGATATTGGTACAAAAGTAAATTTATCGTTTTT
GTTTTAATTACTTATTATGAAATGTAAAT	AATATCATAGATGCGACTACAACGCCGTCTGACACG
GTTTTAATTACTTATTATGAAATGTAAAT	GTCAAATTGCTCATTGAAATAAAGCGGGTTTGTGATT
GTTTTAATTACTTATTATAAAATGTAAAT

>NC_016011|2|2|469832-470314|CRISPRCasFinder
GTTTTAATTACTTATTATGAAATGTAAAT	TCAATTCCCTTGTTCGCTATAAACGGATGGAATAAA
GTTTTAATTACTTATTATGAAATGTAAAT	AGCTTCCTTTTTTTAAGAAATTAGCAACATTTTCAGC
GTTTTAATTACTTATTATGAAATGTAAAT	GGAGGAACAGCGACCGGTTTCGGCTCGGATATTA
GTTTTAATTACTTATTATGAAATGTAAAT	TAGCTTTGCATTTTTTCAGTGATAGAAGTCGCATAT
GTTTTAATTACTTATTATGAAATGTAAAT	AACGATATTGGTACAAAAGTAAATTTATCGTTTTT
GTTTTAATTACTTATTATGAAATGTAAAT	AATATCATAGATGCGACTACAACGCCGTCTGACACG
GTTTTAATTACTTATTATGAAATGTAAAT	GTCAAATTGCTCATTGAAATAAAGCGGGTTTGTGATT
GTTTTAATTACTTATTATAAAATGTAAAT

>NC_016011|2|2|469832-470314|CRT
GTTTTAATTACTTATTATGAAATGTAAAT	TCAATTCCCTTGTTCGCTATAAACGGATGGAATAAA
GTTTTAATTACTTATTATGAAATGTAAAT	AGCTTCCTTTTTTTAAGAAATTAGCAACATTTTCAGC
GTTTTAATTACTTATTATGAAATGTAAAT	GGAGGAACAGCGACCGGTTTCGGCTCGGATATTA
GTTTTAATTACTTATTATGAAATGTAAAT	TAGCTTTGCATTTTTTCAGTGATAGAAGTCGCATAT
GTTTTAATTACTTATTATGAAATGTAAAT	AACGATATTGGTACAAAAGTAAATTTATCGTTTTT
GTTTTAATTACTTATTATGAAATGTAAAT	AATATCATAGATGCGACTACAACGCCGTCTGACACG
GTTTTAATTACTTATTATGAAATGTAAAT	GTCAAATTGCTCATTGAAATAAAGCGGGTTTGTGATT
GTTTTAATTACTTATTATAAAATGTAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_016011.1\|WP_173362397.1\|477348_478710_+\|glycoside-hydrolase-family-125-protein	unknown	unknown	gnl\|CDD\|377716
NC_016011.1\|WP_014091953.1\|473137_473974_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_016011.1\|WP_014091955.1\|476432_477299_+\|ROK-family-protein	unknown	unknown	gnl\|CDD\|224851
NC_016011.1\|WP_014091958.1\|479802_481551_+\|class-I-mannose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|380413
NC_016011.1\|WP_014091948.1\|468327_469350_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|274695
NC_016011.1\|WP_014091944.1\|463932_464802_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|274215
NC_016011.1\|WP_014091959.1\|481635_482013_-\|DUF1304-domain-containing-protein	unknown	unknown	gnl\|CDD\|226282
NC_016011.1\|WP_173362396.1\|464779_465568_+\|type-I-B-CRISPR-associated-protein-Cas5	cas5	cd09658_cas5_CAS-I-B	gnl\|CDD\|273860
NC_016011.1\|WP_014091942.1\|461515_462238_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	pfam01881_cas6_CAS-I:CAS-III	gnl\|CDD\|273848
NC_016011.1\|WP_014091941.1\|460556_461198_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NC_016011.1\|WP_014091940.1\|459095_460535_+\|hypothetical-protein	unknown	unknown	unknown
NC_016011.1\|WP_014091951.1\|470921_472166_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270452
NC_016011.1\|WP_014091957.1\|478808_479681_+\|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224651
NC_016011.1\|WP_014091943.1\|462254_463943_+\|type-I-B-CRISPR-associated-protein-Cas8b1/Cst1	cas8b2	cd09754_cas8b2_CAS-I-B	gnl\|CDD\|187884
NC_016011.1\|WP_014091960.1\|482157_483573_+\|multidrug-efflux-MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NC_016011.1\|WP_014091946.1\|465637_467848_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|224124
NC_016011.1\|WP_014091947.1\|467858_468347_+\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
NC_016011.1\|WP_014091952.1\|472244_473135_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NC_016011.1\|WP_014091949.1\|469354_469633_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NC_016011.1\|WP_014091954.1\|473989_476419_+\|glycosyl-hydrolase	unknown	unknown	gnl\|CDD\|212103

Protein	Function_ID	Function_description	E-value
NC_016011.1\|WP_173362397.1\|477348_478710_+\|glycoside-hydrolase-family-125-protein	gnl\|CDD\|377716	pfam06824, Glyco_hydro_125, Metal-independent alpha-mannosidase (GH125). This family, which contains bacterial and fungal glycoside hydrolases, is also known as GH125. They function as metal-independent alpha-mannosidases, with specificity for alpha-1,6-linked non-reducing terminal mannose residues. Structurally this family is part of the 6 hairpin glycosidase superfamily.	0
NC_016011.1\|WP_014091953.1\|473137_473974_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	2.03773e-61
NC_016011.1\|WP_014091955.1\|476432_477299_+\|ROK-family-protein	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	1.42772e-70
NC_016011.1\|WP_014091958.1\|479802_481551_+\|class-I-mannose-6-phosphate-isomerase	gnl\|CDD\|380413	cd07010, cupin_PMI_type_I_N_bac, Phosphomannose isomerase in bacteria and archaea, N-terminal cupin domain. This subfamily contains type I phosphomannose isomerase (PMI; E.C. 5.3.1.8; also known as mannose-6-phosphate isomerase) found in many bacteria (e.g. Bacillus subtilis) and archaea. PMI catalyzes the reversible isomerization of fructose-6-phosphate (F6P) and mannose-6-phosphate (M6P), the first committed step in the synthesis of mannosylated glycoproteins. The active site, located within the N-terminal jelly roll-like beta-barrel cupin fold, contains a single essential zinc atom and forms a deep, open cavity large enough to contain M6P or F6P. PMI type I also has a C-terminal beta-barrel fold which has diverged considerably from the N-terminal domain and is not included here. This subfamily does not contain an alpha helical domain that exists in eukaryotic and some prokaryotic PMIs. F6P is a substrate for glycolysis and gluconeogenesis, while M6P is a substrate for production of activated mannose donor guanosine 5'-diphosphate D-mannose, an important precursor of mannosylated biomolecules such as glycoproteins, bacterial exopolysaccharides and fungal cell wall components. PMI is also essential for survival, virulence and possibly pathogenicity of some bacteria and protozoan parasites, as well as for cell wall integrity of certain yeasts. Thus, PMI is a potential target against fungal infections causing serious illness or death.	8.54885e-54
NC_016011.1\|WP_014091948.1\|468327_469350_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274695	TIGR03641, cas1_HMARI, CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes Cas1 subgroup that includes Cas1 proteins of the related HMARI and TNEAP subtypes of CRISPR/Cas system.	5.20489e-161
NC_016011.1\|WP_014091944.1\|463932_464802_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|274215	TIGR02585, conserved_protein, CRISPR-associated protein Cas7/Cst2/DevR, subtype I-B/TNEAP. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This clade is a member of the DevR family (TIGR01875) and includes the DevR protein of Myxococcus xanthus, a protein whose expression appears to be regulated through a number of means, including both location and autorepression; DevR mutants are incapable of fruiting body development.	2.69597e-55
NC_016011.1\|WP_014091959.1\|481635_482013_-\|DUF1304-domain-containing-protein	gnl\|CDD\|226282	COG3759, COG3759, Predicted membrane protein [Function unknown].	2.07373e-40
NC_016011.1\|WP_173362396.1\|464779_465568_+\|type-I-B-CRISPR-associated-protein-Cas5	gnl\|CDD\|273860	TIGR01895, conserved_hypothetical_protein, CRISPR-associated protein Cas5, subtype I-B/TNEAP. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This family is represented by TM1800 from Thermotoga maritima. It is related to TIGR01868 (CRISPR-associated protein, CT1976 family).	1.08138e-22
NC_016011.1\|WP_014091942.1\|461515_462238_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	3.01909e-26
NC_016011.1\|WP_014091941.1\|460556_461198_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	4.54651e-54
NC_016011.1\|WP_014091951.1\|470921_472166_+\|extracellular-solute-binding-protein	gnl\|CDD\|270452	cd14749, PBP2_XBP1_like, The periplasmic-binding component of ABC transport systems specific for xylo-oligosaccharides; possesses type 2 periplasmic binding fold. This group represents the periplasmic component of an ABC transport system XBP1 that shows preference for xylo-oligosaccharides in the order of xylotriose > xylobiose > xylotetraose. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	5.38128e-39
NC_016011.1\|WP_014091957.1\|478808_479681_+\|MurR/RpiR-family-transcriptional-regulator	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	2.33293e-56
NC_016011.1\|WP_014091943.1\|462254_463943_+\|type-I-B-CRISPR-associated-protein-Cas8b1/Cst1	gnl\|CDD\|187884	cd09754, Cas8a1_I-A, CRISPR/Cas system-associated protein Cas8a1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Large proteins, some contain Zn-finger domain; signature gene for I-A subtype; also known as CXXC_CXXC family.	7.00452e-25
NC_016011.1\|WP_014091960.1\|482157_483573_+\|multidrug-efflux-MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	2.32843e-82
NC_016011.1\|WP_014091946.1\|465637_467848_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	1.64235e-60
NC_016011.1\|WP_014091947.1\|467858_468347_+\|CRISPR-associated-protein-Cas4	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	4.54003e-59
NC_016011.1\|WP_014091952.1\|472244_473135_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	4.99846e-67
NC_016011.1\|WP_014091949.1\|469354_469633_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	8.20733e-29
NC_016011.1\|WP_014091954.1\|473989_476419_+\|glycosyl-hydrolase	gnl\|CDD\|212103	cd10791, GH38N_AMII_like_1, N-terminal catalytic domain of mainly uncharacterized eukaryotic proteins similar to alpha-mannosidases; glycoside hydrolase family 38 (GH38). The subfamily of mainly uncharacterized eukaryotic proteins shows sequence homology with class II alpha-mannosidases (AlphaAMIIs). AlphaAMIIs possess a-1,3, a-1,6, and a-1,2 hydrolytic activity, and catalyze the degradation of N-linked oligosaccharides. The N-terminal catalytic domain of alphaMII adopts a structure consisting of parallel 7-stranded beta/alpha barrel. This subfamily belongs to the GH38 family of retaining glycosyl hydrolases, which employ a two-step mechanism involving the formation of a covalent glycosyl enzyme complex; two carboxylic acids positioned within the active site act in concert: one as a catalytic nucleophile and the other as a general acid/base catalyst.	2.93212e-87

>NC_016011.1|WP_014091949.1|469354_469633_+|CRISPR-associated-endonuclease-Cas2
MYVILIYDISVENGGAKVWRNVFKICKRYLTHVQKSVFEGEITPALLVKLRMELDNYIRADVDSVILFSSRQQKWLEKEFWGLADEKTSNFF
>NC_016011.1|WP_014091948.1|468327_469350_+|type-I-B-CRISPR-associated-endonuclease-Cas1
MNIAIFKGGSEIESYYLFSDGELKRKDNVIRLTAPDGRFKDLKVELTREIFLFGEVNMNTKGLNYIGQLGIPIHIFNYYGFYSGSYYPRETNVSGQLLIAQVENYSDEKKRLYIASKFIDAASFNLLRNLRYYKQRGKDVLEEMDEIKFLRKSIGRMEDIQGLMGIEGNIRKVYYSAWQKIINQEIDFEKRVKRPPDNMINTLISYVNSLVYSSCLTEIYKTQLNPVISYLHSAGERRFSLCLDIAEIFKPLIADRIIFSLLNKNVITEDDFEKEANFCYMNKSARQKILQAYDLRMKETIKHRDLGRHVSYRHLIRLECYKLVKHLMNDKKYEGFKIWW
>NC_016011.1|WP_014091947.1|467858_468347_+|CRISPR-associated-protein-Cas4
MRISGTHVYYYFVCKRKLWCFSKEIRMEHLDENVQLGKLLDETSYSRENSQVMIDETVNIDFIKDWKVLHEVKKSRAIEEAGIWQLKYYMYFLKQKGIVIEKGIVDYPKLRQRETIFLLKEDESEIENVLIEIESITKDTKPPKVIDKPLCKKCAYYEYCYI
>NC_016011.1|WP_014091946.1|465637_467848_+|CRISPR-associated-helicase/endonuclease-Cas3
MQKYLAKSNPPETIQEHTDNLLKNFQTLKKLYPEINIDWYLLELVCLLHDLGKMNQLFQKKLGNVSGGGKEIPHGYLSVAFVPYSKLEDLGYSEDEIQVVYQAIARHHERKKDFTEQEWETEIEGLSKQWEIFSYERLADNADYSSEIDTIYFYPEARIFEDEDTVGSENFKNYVQLKGLLNRIDFAASAGIDVELENDFLQESMEHQLSNFREENAAADWNLLQKYMLQHQNENVIVIAETGMGKTEAGLLWLGNNKGFFTLPLRTAINAIYTRVTKEIVTDKQAQRVGLLHSETYSQYLLHEENTEMEIDEYYTRTRQMSLPVTICTLDQLFDFVFRYAGFEHKLATLSYSKVIIDEIQMYSPDLLAYLILGLSYIDKFGGKFCVMTATLPGIVLDLLHENEVDFIQPEEKFVSERVRHSVEVVHTEIDSTFIEPFFAGNRILVICNTISKAKKIYSELTGMFPNKKIRLIHSQFIKKDRSKKEEEIFEDGQKENPESCIWVTTQVVEASLDIDFDLLFTELSDINGLFQRMGRCYRNRALDVDTNVYVFDGGEKVCSGVGQFIDKTIFMNSKKALEICHGALTEMKKMELVEQIYSTEALKESGFYDELTQALNYVKGFDSYELDKKEVRSKFRNINSITAIPSTVWQENEKEITRCMEILDKPSKEASKKEKMIARTNLAEFMLNIPDYLYKKSEEEVHRINRYETVIEFKCDYSEDVGIIMREKQKESLFF
>NC_016011.1|WP_173362396.1|464779_465568_+|type-I-B-CRISPR-associated-protein-Cas5
MLIMKAIRVKLWQDLVNYKKPTSFQLKETYPLPPYSTVIGMVHTLCGFTSYHEMKISIQGKYFSKVNDLATRYEFKNGMTYDASRHQIKAGDYGVSRGISTVELLVDLELLLHIIPENPSLVPVIEKAFKEPIEYPSLGRREDIATIQAVDIVEVEKRQPKENKSVNIYKDYNAYVPISLAESNLVRFKTQESAVGRRNLLGTRYLLTEKYERVNHGTEKAPKFFRKWRKKDVIYSSRIFVSKNDVFFLDKDDCLVFIEEEV
>NC_016011.1|WP_014091944.1|463932_464802_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MKNKGLAMTIIFQAESANYGESLGNISALKKISRNNGDQYTYISRQAIRYNLMEQIGEKAAPVKAEGSGDKKVIQFLSETSIADFPELDFFGYLKTEKGTGGQKRSAKVRLSNAISLETFKGDLDFLTNKGQADKINENMNIAQAEIHKSYYRYTVTIDLDQIGIDGTVEIDNKEKARRVKKLMDTVAFLYRDIRGRREDLKPLFVIGGVYDVKNPVFQNVVDVLDNKIVIENIADLLKYNEIGESTMVGIIDGQFTNTDEVKARLGAETVPAFFNKIKEKIDTYYEGN
>NC_016011.1|WP_014091943.1|462254_463943_+|type-I-B-CRISPR-associated-protein-Cas8b1/Cst1
MQKEIELRTNEWLQNAGIIGFINIIGKENVRIDGQTLNFSTDVLADFETNYFNYFIKEYKETLAWHKIVSYKEKMEYYRAENFASFDEKTLENLNKYVKDVVKFYLKKSNYIKVFPLIDPKANVEEWLGKLSPIKLSKKQKLEDGKVELLEEVKETYDQLDIIIDFCASEKGLKYLGAKNLIYSVINNGWSGVSFLYRQTKFIDPYEDYKTTFLDPVFEYLETDLSKAKYNCFICNQPIKTLKLDLSFMNDVGFDTARKTSHVWDFNNDVVTCPICRLIYSCVPAGFTYVYGEGMFVNDSVSIDKLYSVNEHIRESILHFNNDGINSVNPYRALVESITMEKEKQRRFDLADIQLVRYENEHYRFNLLSKKMLHILNDSKTILQSLIKCGYKEGNLNINLYKEVIQHLMNNENLFTLIHKLIFYKQMNVNGLYYNMGHVAGILEINTKFLKEIDVMTNISQKQLWFVQSCGTEFKEGYFGKKSENKITGITYKLLNALKVNDKDGFMDTLLNSYSYLAKPIPSVFMNVFSNDEAFKSVGYAFMLGVGGERTKKEDGGNTDEK
>NC_016011.1|WP_014091942.1|461515_462238_+|CRISPR-associated-endoribonuclease-Cas6
MRLKINCDFDSILIPKDYRSKIVSLFKTGIMKSSPERYNDLFGGNKRKNYTFSIYLPKPKNKGLEIHLEETNCIINFSTGDAEMGIIFYNAFMYLKNKELPFGAENKIVLKNIQIQAEKKIIGNKTKMKTLAPIVAKDHDKVTYKNWFYSFGDKEFETILKRNMLPFLIEEFGEQARYDLEKLKITPISMKKVVVYCYEIHMECSVGVFELEAEPYLQKYFLQNGFGSQTGSGFGMLEQL
>NC_016011.1|WP_014091941.1|460556_461198_+|ABC-transporter-ATP-binding-protein
MSDTIIECINVSKEFKHIQLFTDVNITFTEGKCYGIKGHNGSGKSIFFKMLCQFLTPTTGEIRINSRFLNKKDNYPSDFGIIIDKPGYIANKTGLENLMELADINKKVSIDIVKETMKRVGIDPDIKQKMKNYSLGMRRKIAITQAIMEDQKVILLDEPFNGLDSSSVENIRNLIKELKKEQKTIIIISHNQEDLDILCDEVYQIDNKQIKHM
>NC_016011.1|WP_014091940.1|459095_460535_+|hypothetical-protein
MSLAKITNTFINVKNLSIFSIASLYGILALQGSFNQYNMNFAERSVSLLSDPYLFIYFILPIWIMLVSKEILTRKDYQNTIRLKTKQRYNLWLLRKCMLISFSLITVLLISSICISVGGDVKLTWSSHIANYQETGLIVSVLNDLISSPISAILVQLLVYFIFLSTIAYFIITITYKIHTPIFIYCVSLLILIYMMYTFTFAMEPLYMNISSLAFAYRVLGQLSQEIIVYTVILVTCILLNTNKVLRKINDLYMYQKKHIIFLAVILVSYVFLGINGADLSINDYIISTNYGSSNEGYTINSILFYAIIYLGIPYLILLGINEKQQLIYYELIRQKTMNKWIFKNILAALQYSCLYLMVTFLIMIGTSYKNYQELLSIDGEILYQYFINGSLQIFFYSLIILLTYSITGKITYALYLNLGLIILLLPVININHILPIGLNAMGMLEDRTPYQLSLQLLIAILMITMILILVNRKRTIPQ
>NC_016011.1|WP_014091951.1|470921_472166_+|extracellular-solute-binding-protein
MKKIVSISCIVAVLMLLASCGSGESSSSKVEFYTDKGGENVGILNSMSEQIEKDGGVGYKTVGYTEVTSYETTVQQSLDSEKAPGLFTWWSGDKLKKLVDNDLVVDLTKEWKEYYEKEGVNPGLADAFTIDGKVYAAPFSVLYNGILYNKHLFDKYDLEVPTTWDEFIKVCDTLKANKIEPIGLKNDPWASFLWFQTLIASYDPDLYVGLTNGDIKYTDPEMKKVMKIWQKMITKGYFGDPVDPASQIKMFSTDKSAMVYEPTVTSATLKKEYNMEPGKDFDVFVAPSMTADQKQVIFFEASPIVVSKESKLSAEAQKVLRSFYKKDVQQIFVDEAGIINTDNTKSSDPVNGSFVKEAADANKYQVMVRYYEATPSEVVTVATDELWKFFYKPTDAVLDDTLNTIQKVADSAFK
>NC_016011.1|WP_014091952.1|472244_473135_+|sugar-ABC-transporter-permease
MSLQAKANLKRGRGLKPYLYIAPAVLFVFCFCILSIIFTLVISFTDWSGLGSFNFVGFDNYVAVFQDKNFLLSCINTLVWVAAGLIIPVVLPLLFAIAIIKSSFATIFKNLFYFPNAVSGVIVGLIMTSLLSMYGLPQLLGMLGFENLDKNWLNIPYVNTGVMIVAGIWQGIGLNMLLFIIGLVNMPTEPIEAAKLEGASGLALYTKIILPLLKPTIIVVVLMSLVNSFKTFDSIWIMTGGGPYRTSETLAVTMYKESFSNNHLGMGSAIAVMLSVIILVISIFYLRKTFNKEGSN
>NC_016011.1|WP_014091953.1|473137_473974_+|carbohydrate-ABC-transporter-permease
MIQQKHAGIGKWTVNIILIILAVIWIFPFLYVIVNAVKSSAEYSTGNFWDLPKSFSIAENWEYLTQQIQLGSGFINSLIYGTLGGGLGIIMAALAAYAIETLKIKHGLLWFFVIYSGTIFPFQVYLIPIFKAYNKVGLYDTQLGMVLIYAALIIPFSVFVLRNFLMGISKEMLESARMDGASDFYIFRKIYMPMARAPLAAVFLFQFTWIWSDLLFGMTLTKSESARPVMAAVSLLGGSTIQKVPPILLAAIIVSIPTIILFILSHRNLEKGFVVTTK
>NC_016011.1|WP_014091954.1|473989_476419_+|glycosyl-hydrolase
MTLSKKWKLYVLHHSHTDIGYTERQEKLKRYHVDFIQQAIDILMEIEDGKRPEWEGFRWVCENYWQVENFLKNSSEENIACFERYVQAGLIDISLNYLNMTELVDDEVLNHKLAQGRSYADHLAVPLDSAMSADINGYSWGYADALANNGIENLFSCIHTHHGMYPHGKKHHGFWWEGPSGERVLTWVSDHYHMGNELCLVPEHGITYLLEDRFNPKAEVADFEVAEERIFNYIEKLDNDVEYDYYFVPIMVSGMSTDNGAPNGRILERVKTWNELHGDQIEIEMITLNHFFDILRDEMNELPVYRGDWNDWWADGVGSTPAVVKHYKDAQRKYHIGKQLAPDFVAADKQYLDDVEYELALYAEHTWGYSSSVTEPWETLVNDLDFRKSSYAIRANQLASLKLDEILAVKGEVTIRPDRDKLFKVINPQATARTDSVCLYIEHWEDVEGSAVDILLQNIEVVDELTGEVLPSQVREIARAKEVEVVLELTALEEKILRIRLKKELQKEPYRYLAVDKINDIMYDGWQEGLRVNAHQVETKYYSMTFDETNGIVAMIDKRDGNSLLRDSLEHPTFVGIYERTATEPNAWEVRHTMGRNRKKINTDRHVSKLRNIQVCESGEVSATVVFTYDLEGTQMYEIHMKVYRDTPKIDITLRLHKDSIWDPENLYISFPFTTGETEELYFDKMGCLVRPGIDQLPGTNQEFYLVQEGAVYVGAEKSVILALKDTPLLVLGELEHHLIELSGQRGAEKNKEPLYVWAMNNFWETNFKVDLAGFYEFRYTLATLQTTRADVAIDACKSYNQGFLSMYV
>NC_016011.1|WP_014091955.1|476432_477299_+|ROK-family-protein
MYRIGIDIGATNMRVALFDSDNQLIAREQVKTEAKLGPVQALGKLVSMVRLVDPERLAIGIGIGAPGPLDVTNGTVLDAPNLPGWHGFPIRDELERLVNVPVFLMNDAKAAALAEAKIGSGVGYDSVQYITVSTGIGGGFICRGELFPGSHGHASELGNMIVDVSSPNSTLENTCSGSALLRQSKQLFGENQTAAELFVQYEANQEEARQVIEQWLHHFSAAVTSIIQVIDPEVFVLGGAVILRHPWLVEKLHPMVTKRVYSTMREDVQLKVASLGDDAGLYGASMFV
>NC_016011.1|WP_173362397.1|477348_478710_+|glycoside-hydrolase-family-125-protein
MMGEDTYFRLRRITDEILKEAASDNTELATLIDGTIDRILQQVDLSEKLQRMFRKCMLNTITTTLVQKKDDSAFLFTGDIPAIWLRDSGGQLRVFLNLDDASGKLYDVIGAVIRQQFRYIRLDPYTNAFNFGGNGNCWSEIDQSERSNPWSWERKYELDSLCFPVELAYFYWKQTARVDLFDEGFLAAIKELIRVFRVEQHHEACSEYFFIRNNGIEQDSLPNQGRGTKVGYTGMIWSGFRPSDDACEYGYLLPANMFAVVILGYLEEMVVAFYPKEMELLTAITTMKKEVQEGIDKFGIIDHPKYGKIYAYEVDGLGNSNIMDDTGVPSLLSLPYIKYCDADEAIYQNTRRFSLSKDNRYYFEGTAAKGLGSPHTPPEYVWHMGLAIQGLTSIDDAECQELLRLFETTDAGTELTHEGFLADDPTVYTREWFSWSNSIFCEFILKEIGKWKL
>NC_016011.1|WP_014091957.1|478808_479681_+|MurR/RpiR-family-transcriptional-regulator
MKSGIVRLQALAKQSMGSYQDIAKYIVTNAETVKTMHITQLADECFTSPATIVRMCKKLGYKGYTDFKQDLVLNLHKWFFEKQEVYNRGYIYPNKAAIEIGEVITNLTINGMIKSVQFLDSELVTDLAKILYEAERMDFYGCGISNLVAQDFSYRFLRSGKSTSAFADSHIQISQAQQSDASCVAVGISYGEETQEVITALEIAKQLGAYTISFTSEEDNSLAQVADCNITVAQIEHPEGYVAAASRIEMLHVMDIIYSVYISKYDETVAAKISRTRPYFKKKSGDQEQE
>NC_016011.1|WP_014091958.1|479802_481551_+|class-I-mannose-6-phosphate-isomerase
MGNNQTRYNHSPTTKVKGDFKTWTGFQAIFSELSHAIAKSSKKKAILVIETYPGVQIETLRCALEKYFEAATILCADDFAMRGQEIQEKFAMLITEDRVFGRMAAIKMEDYYEKAKLELLRKKVATSDDLTIVFGTGASLVADAEVTVYMDVARWEIQQRMRSGEIGNWNDTNLDEDILRKYKRGFFLDWRAADRLKVELFDKINYYVDANELDHPKMVQWSDYCSGLEQMLQGPFRFVPYFDPGVWGGQWMKENLGLDTSVNNFAWAFDGVAEENSLYLQFGTVRIETPAINAVLKYPMELLGELVYSRFGAELPIRFDFLDTIGGQNLSLQVHPNKEYIKKQFGMDYTQEESYYLLDTKDDAVVYLGVKDDVNSEELIGALEDAQSGEVALDAPRYINTFPAKKHDHFLIPSGTVHCSGADSMILEISLCAYIFTFKLWDWGRLGLDGKPRPVHIEHGKKVINWNRSEKWVAENLVNQFVPLIETKTHTKERTGLYKTEQIYTERDWFSDFIDYDNMEKTVNMLNLVEGDKIVVESLEGKFDDFEVHYVETFVIPAQIERFRIRNIGENERVAILRARIM
>NC_016011.1|WP_014091959.1|481635_482013_-|DUF1304-domain-containing-protein
MTILAFMLTFIVMIEHIYIMILEMFFSNTKLAAKTFGVEKELLANKKVQTLFANQGLYNGFLAAGLAWGLFFAGNVYTGTVQIFFLSCVVIAALFGGATSSKGILVKQGLPAVLALVAVLLVVTI
>NC_016011.1|WP_014091960.1|482157_483573_+|multidrug-efflux-MFS-transporter
MQQERTMERKIRPIPIIASFLMAGFIGLFSETALNMALSDLIQVFDISSATVQWLTTGYLLTLGILVPISGLLLQWFTTRGLFFTAVSFSIAGTLIAAISPTFAILMIGRVVQAVGTALLLPLMFNTILLIFPEHKRGSAMGMIGLVIMFAPAVGPTISGLILENLTWNWIFWISLPFLIIALLFGLKYMQNVSVVTKPKIDVLSIILSTLGFGGVVFAFSSAGEHGWGSATVLTAIIVGGISLALFVWRQLTMEKPLMDLKVFKYPMFTLGLILVFISFMMILSTMILLPLYLQNSLALAAFSAGLVLLPGGVLNGLMSPFTGRLFDAYGPRALVIPGFIVAVIALFFLTRIETDTTALTIIILHSVLMIGISMVMMPAQTNGLNQLPRKLYPDGTAIMNTLQQVSGAIGTAVAITIMTAGQKAYMETAQGAGPEEMVASLTAGIQNAFVFGLIMACIGLVCSLFIRKAK

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Crispr_ID: NC_016011_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016011_3

740336-740736

Orphan

Consensus_repeat	Method
ACAACCAGCTAACGAATTTAGAT	CRISPRCasFinder

6 spacers

The CRISPR arrays of NC_016011_3

>merge|NC_016011|3|740336-740736|CRISPRCasFinder
ACAATCAGCTAACCAATTTAGATGTCAGCAAAAATATAGCATTATATTTACTTTATTTGGATAATAATCAGCTAACAGATTTAGATGTCAGCAAAAATCTGAATTTAGGAGGGATCTATTGTCGTAACAACCAACTAACGAATCTAGATGTGAGCAAAAATCCAAAGTTATCCACCCTTCAGTGTGAAGATAATCAACTAACGAGTTTAGACCTCAGTAAAAATCCAAAGTTAATGTGGCTTGAATGTGAAAATAATCAGTTAGCAAATCTTGATGTGAGTAATAATCCAGAGGTATTGAATATTTATTGTTATAACAACCAGCTAACGAATTTAGATCTCAGTAGTAATGTGAATTTACAGACTTTTTTTTGTTCTGACAACCAGCTAACGAATTTGGAT

>NC_016011|3|3|740336-740736|CRISPRCasFinder
ACAATCAGCTAACCAATTTAGAT	GTCAGCAAAAATATAGCATTATATTTACTTTATTTGGATA
ATAATCAGCTAACAGATTTAGAT	GTCAGCAAAAATCTGAATTTAGGAGGGATCTATTGTCGTA
ACAACCAACTAACGAATCTAGAT	GTGAGCAAAAATCCAAAGTTATCCACCCTTCAGTGTGAAG
ATAATCAACTAACGAGTTTAGAC	CTCAGTAAAAATCCAAAGTTAATGTGGCTTGAATGTGAAA
ATAATCAGTTAGCAAATCTTGAT	GTGAGTAATAATCCAGAGGTATTGAATATTTATTGTTATA
ACAACCAGCTAACGAATTTAGAT	CTCAGTAGTAATGTGAATTTACAGACTTTTTTTTGTTCTG
ACAACCAGCTAACGAATTTGGAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_016011.1\|WP_014092202.1\|745202_746459_+\|GTPase-HflX	unknown	unknown	gnl\|CDD\|225171
NC_016011.1\|WP_014092207.1\|750075_751065_-\|acryloyl-CoA-reductase	unknown	unknown	gnl\|CDD\|176249
NC_016011.1\|WP_014092204.1\|747412_748402_+\|lipoate--protein-ligase	unknown	unknown	gnl\|CDD\|161920
NC_016011.1\|WP_049793584.1\|735899_736706_+\|PTS-transporter-subunit-EIIB	unknown	unknown	gnl\|CDD\|273919
NC_016011.1\|WP_014092203.1\|746535_747408_+\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|277331
NC_016011.1\|WP_014092196.1\|738521_739526_+\|adenosine-deaminase	unknown	unknown	gnl\|CDD\|238645
NC_016011.1\|WP_014092198.1\|741786_742674_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319934
NC_016011.1\|WP_014092190.1\|730868_731426_+\|DNA-topology-modulation-protein-FlaR	unknown	unknown	gnl\|CDD\|181235
NC_016011.1\|WP_014092205.1\|748604_749357_+\|hypothetical-protein	unknown	unknown	unknown
NC_016011.1\|WP_014092191.1\|731556_732396_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|366166
NC_016011.1\|WP_014092200.1\|743638_744247_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223477
NC_016011.1\|WP_014092193.1\|733283_733895_+\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|379275
NC_016011.1\|WP_032363853.1\|737483_737687_+\|PTS-glucose-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|376324
NC_016011.1\|WP_077905826.1\|736654_737317_+\|PTS-transporter-subunit-EIIC	unknown	unknown	gnl\|CDD\|273919
NC_016011.1\|WP_014092194.1\|734014_734797_+\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NC_016011.1\|WP_014092201.1\|744255_744876_+\|flavin-reductase-family-protein	unknown	unknown	gnl\|CDD\|224766
NC_016011.1\|WP_014092192.1\|732517_733198_+\|Crp/Fnr-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223736
NC_016011.1\|WP_014092199.1\|742673_743639_+\|ring-cleaving-dioxygenase	unknown	unknown	gnl\|CDD\|319935
NC_016011.1\|WP_014092206.1\|749378_750029_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NC_016011.1\|WP_014092189.1\|730205_730706_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_016011.1\|WP_014092202.1\|745202_746459_+\|GTPase-HflX	gnl\|CDD\|225171	COG2262, HflX, GTPases [General function prediction only].	1.25376e-170
NC_016011.1\|WP_014092204.1\|747412_748402_+\|lipoate--protein-ligase	gnl\|CDD\|161920	TIGR00545, Probable_lipoate-protein_ligase_A, lipoyltransferase and lipoate-protein ligase. One member of this group of proteins is bovine lipoyltransferase, which transfers the lipoyl group from lipoyl-AMP to the specific Lys of lipoate-dependent enzymes. However, it does not first activate lipoic acid with ATP to create lipoyl-AMP and pyrophosphate. Another member of this group, lipoate-protein ligase A from E. coli, catalyzes both the activation and the transfer of lipoate. Homology between the two is full-length, except for the bovine mitochondrial targeting signal, but is strongest toward the N-terminus. [Protein fate, Protein modification and repair].	8.07223e-109
NC_016011.1\|WP_049793584.1\|735899_736706_+\|PTS-transporter-subunit-EIIB	gnl\|CDD\|273919	TIGR01995, beta-glucosides_PTS_EIIBCA, PTS system, beta-glucoside-specific IIABC component. This model represents a family of PTS enzyme II proteins in which all three domains are found in the same polypeptide chain and which appear to have a broad specificity for beta-glucosides including salicin (beta-D-glucose-1-salicylate) and arbutin (Hydroquinone-O-beta-D-glucopyranoside). These are distinct from the closely related sucrose-specific and trehalose-specific PTS transporters.	8.32315e-62
NC_016011.1\|WP_014092203.1\|746535_747408_+\|metallophosphoesterase	gnl\|CDD\|277331	cd07385, MPP_YkuE_C, Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain. YkuE is an uncharacterized Bacillus subtilis protein with a C-terminal metallophosphatase domain and an N-terminal twin-arginine (RR) motif. An RR-signal peptide derived from the Bacillus subtilis YkuE protein can direct Tat-dependent secretion of agarase in Streptomyces lividans. This is an indication that YkuE is transported by the Bacillus subtilis Tat (Twin-arginine translocation) pathway machinery. YkuE belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	2.04131e-68
NC_016011.1\|WP_014092196.1\|738521_739526_+\|adenosine-deaminase	gnl\|CDD\|238645	cd01320, ADA, Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in the purine pathway. Low, as well as high levels of ADA activity have been linked to several diseases.	3.03911e-101
NC_016011.1\|WP_014092198.1\|741786_742674_+\|VOC-family-protein	gnl\|CDD\|319934	cd08346, PcpA_N_like, N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins. The N-terminal domain of Sphingobium chlorophenolicum (formerly Sphingomonas chlorophenolica) 2,6-dichloro-p-hydroquinone1,2-dioxygenase (PcpA), and similar proteins. PcpA is a key enzyme in the pentachlorophenol (PCP) degradation pathway, catalyzing the conversion of 2,6-dichloro-p-hydroquinone to 2-chloromaleylacetate. This domain belongs to a conserved domain superfamily that is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases.	1.99942e-40
NC_016011.1\|WP_014092190.1\|730868_731426_+\|DNA-topology-modulation-protein-FlaR	gnl\|CDD\|181235	PRK08118, PRK08118, DNA topology modulation protein.	3.58708e-41
NC_016011.1\|WP_014092191.1\|731556_732396_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	3.92446e-21
NC_016011.1\|WP_014092200.1\|743638_744247_+\|alpha/beta-hydrolase	gnl\|CDD\|223477	COG0400, COG0400, Predicted esterase [General function prediction only].	1.26042e-67
NC_016011.1\|WP_014092193.1\|733283_733895_+\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|379275	pfam13577, SnoaL_4, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	7.84916e-06
NC_016011.1\|WP_032363853.1\|737483_737687_+\|PTS-glucose-transporter-subunit-IIA	gnl\|CDD\|376324	pfam00358, PTS_EIIA_1, phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1.	9.1015e-26
NC_016011.1\|WP_077905826.1\|736654_737317_+\|PTS-transporter-subunit-EIIC	gnl\|CDD\|273919	TIGR01995, beta-glucosides_PTS_EIIBCA, PTS system, beta-glucoside-specific IIABC component. This model represents a family of PTS enzyme II proteins in which all three domains are found in the same polypeptide chain and which appear to have a broad specificity for beta-glucosides including salicin (beta-D-glucose-1-salicylate) and arbutin (Hydroquinone-O-beta-D-glucopyranoside). These are distinct from the closely related sucrose-specific and trehalose-specific PTS transporters.	4.66655e-53
NC_016011.1\|WP_014092194.1\|734014_734797_+\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	8.58101e-48
NC_016011.1\|WP_014092201.1\|744255_744876_+\|flavin-reductase-family-protein	gnl\|CDD\|224766	COG1853, COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only].	2.08714e-32
NC_016011.1\|WP_014092192.1\|732517_733198_+\|Crp/Fnr-family-transcriptional-regulator	gnl\|CDD\|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	1.89412e-20
NC_016011.1\|WP_014092199.1\|742673_743639_+\|ring-cleaving-dioxygenase	gnl\|CDD\|319935	cd08347, PcpA_C_like, C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins. The C-terminal domain of Sphingobium chlorophenolicum (formerly Sphingomonas chlorophenolica) 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins. PcpA is a key enzyme in the pentachlorophenol (PCP) degradation pathway, catalyzing the conversion of 2,6-dichloro-p-hydroquinone to 2-chloromaleylacetate. This domain belongs to a conserved domain superfamily that is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases.	3.99543e-73
NC_016011.1\|WP_014092206.1\|749378_750029_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	1.35878e-30
NC_016011.1\|WP_014092207.1\|750075_751065_-\|acryloyl-CoA-reductase	gnl\|CDD\|176249	cd08289, MDR_yhfp_like, Yhfp putative quinone oxidoreductases. yhfp putative quinone oxidoreductases (QOR). QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR actin the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site, and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	0

>NC_016011.1|WP_014092196.1|738521_739526_+|adenosine-deaminase
MNEQHIKVIPKVELHCHLDGSIRIETLRKVYEIQGNPLGFSDERLQQMTVAAAHCTLTKYIDCFRLVSSGLHTKEALQLALLDVVEQASLENIIYMEIRLSPLHLRTVTFSMEEVAEALINACQIAEKHYSIKIGLIFCCMRRQLEKSNLAVINLAKKYLGMGVVAIDLAGDEGRYPTKDYQSLFTYASRIGVPYTIHAGETGNLSSVLTALEFGASRIGHGIALAQSQQAMEKAVKQEVLLEMCPVCNIQTGAAQNWQSYPVDTFIRNKLPICFNTDNRTVSNTTLTNEFLQVNQHCFALSEELLLKQAKTALAHSFTDDTTKQVLKKQLIMT
>NC_016011.1|WP_032363853.1|737483_737687_+|PTS-glucose-transporter-subunit-IIA
MGVGFAVRPTTGTLFSPIAGTVESIFPTNHAITLKSVPGIDVLVHIGLETVELGGAGILLEVKKGDR
>NC_016011.1|WP_077905826.1|736654_737317_+|PTS-transporter-subunit-EIIC
MQKIIPKSLHFTFVPFLTLIIGVPATILVFGPLANIASSIISSAILGLFGFSPIVTALFVGILYTPLVILGLHWPLVAIGINNLATAGTDYLLPMIFTAPSAQMAVVFAVYLKTKNPDVKKICVPAMVSDFFCIIEPSIYGVTLPVKRRFVYTCIGTAVGALIIAVAGVHNFASTIGVLGIGGFINPQTGDVSYVIVVALASLATMLIAFLLAFFTFKEA
>NC_016011.1|WP_049793584.1|735899_736706_+|PTS-transporter-subunit-EIIB
MGKYDKLNAFIIENVGGDSNITALTHCVTRLRFTLKDESLVNRDALINHEEIMTAQAANGQYQVVVGMQVGDIYQEMLPKLSISNHKEETGTNDSSNKDKKTLLNRFIDTITKIITPTLGVMIGCSLILGVQSLLVATKVVSPGDGAFVILNAVGYALFTFFPVILGYTSAKTFNSDPFIGMIVGAALVFPNLLTDLVDSEAIYQLFSGTIFQTNIYSDFLGIPIIFPANGYTSTVIPIIFSMFFYQNGNILSKKLFLNHCISPLFHF
>NC_016011.1|WP_014092194.1|734014_734797_+|DeoR/GlpR-transcriptional-regulator
MGKVESRRNKIIEILNENSILSLANLAESLNVTTETIRNDLKSEQLAGKVVQAHGSVAIAHTTIARDVPYSFRKEVNSKSKSKIADQACKLVSPGQVIAIEHNSISVMLIHMLGQYPQLLNNITIITNSFSIMHYVQEKKLELPIIFLGGTFSLNQENAFGSMTVHQMKELKADISFISPGAIDEDLEITAYKEQDADLQKAIMKNSQKNILLIENSKYPSIAMWKVNHATDYDTIITEVDFTKEQLETLAKAQIDILNI
>NC_016011.1|WP_014092193.1|733283_733895_+|nuclear-transport-factor-2-family-protein
MLLTRNLPYTEETMRAKADILELVQFERFCRDNALWDAMETCFMKDSSVKISWYQGTGHGFIEASKKMTNPAPHKIYNTQIWINGDRAVAIMQATIQTRSIINGVEMELNSDAKLVTRVERIDGSWYIKAFEGVYEKDSLTPVVPSENANVPAELLANFRKSYACLALSLTLNGYEIDNSLPGIDRPEQVAEFFKEADEWLIQ
>NC_016011.1|WP_014092192.1|732517_733198_+|Crp/Fnr-family-transcriptional-regulator
MDIRTELQKSQLCEDFTDNQLTELMTQITVREKHYKNNEILFYTKEATKIFILVNGNVAIAKNTISGKRILGKSVSERGEITGEIYYFSHRNPFWDYAIALEPTTVLEISGIEKEKLQQLDLTLQNRLLVNLLKSVTRKFEYIGEKVRITSEDSVRAKISNYLLGLQQEDGSIELTETREEIADYLDITRPSLSRELGRMQKENIIQIEGNKVIILDVVIFDAFIE
>NC_016011.1|WP_014092191.1|731556_732396_+|alpha/beta-fold-hydrolase
MSILKLEGANLSYQKVGQGPVLIFIPGANGTGDIFLPLAAELQEHFTVVTVDRRAYGKSGVTEALPERASLAHDDYRVKRDAADIAALAKEVSDEPVYILGSSSGSIVAMHVLRDYPAVVKKIAFHEPPINTFLPDAKKWQDSNEEIVQTAINKNMAEAMQLFGKTLHIAPIDAVSMSKPAVSTEDAIEEDPVTKQMKYWFQYEIRQYTSSDISVADFEPYIEKITLLNGTDSKGSFPQDVNKYLSEQTGLEIVDIPGGHLGYIQKPAGFAEVLLEMWS
>NC_016011.1|WP_014092190.1|730868_731426_+|DNA-topology-modulation-protein-FlaR
MNQFNDLQSKLKNKQRILVIGPNGAGKSTFSSKLGKYLSMEVYHLDKIFWKKDWEHLSELEFKLKIAEILNSEQPYIIDGDYLSSLKDRLAYADLVIWIKIPVSICLINIMKRRFKYLFAKRPDMAEGCDEKLKLSFLMYAAKYNKRSGIPTKELLENDYKGETYIIESYRVYKEYCKALGIVAG
>NC_016011.1|WP_014092189.1|730205_730706_+|hypothetical-protein
MKKPVKISLIIVGIAVVIFAGVMLSYRFLKSMDVTETAEVNKSATGSHVLLATQGSKFKDSVIDQVKEEMEGKNVHISIIDTTKLDKVKADDYDKVVLFTTVQSDDIPENVTTFMNDNKDKNIHIAVTADSGNWDDQPNDVDAISEASKSENKQDFVDDLTHAILK
>NC_016011.1|WP_014092198.1|741786_742674_+|VOC-family-protein
MIQGIHHVSALTKSFTENHHFYAEVLGLRLVKNTVNQDNIKMRHLFYGDYAGTPGTLLTFFEIPKIGSSYQESTYFGNITLGIPKDTTNYWEKRLNDYAVPFKKAAKTLSLHDPDQMGIILTEITETISHPTIHTDIPSAQQIVRILGADYHVPSPTETSPFFTNYFGLDSQNGVLVDSNQMSFTRLYKTGSEKKSRTGRGTIDHIAYTVKTKEAVDKFHEIALQNKLKIEEFVDREYFKSLYIKEPSGLRIEFASAEPGFTLDEPLETLGEKLALPSFLEEKRTEIETYFGGKE
>NC_016011.1|WP_014092199.1|742673_743639_+|ring-cleaving-dioxygenase
MMKDLKGIHHVTAMTSSAEKNYAFFTEVLGMRLVKKTVNQDDIHTYHLFFADDKGSAGTDMTFFDFPNLPKGRHGTDSISRVSFRVPTDGALEYWQDRFNQLEVPHGEIQTLFGQKYLTFQDFDDQQLQLVSDEKDSGVAPGTPWKNGPVPEKYAIYGLGPVFLTVVSLTNMDAILQSILGFRKVTEENGLHLYEVGEGGNGAQVVVEERTDIPAAMQGYGGVHHVAFRVEDHDELQKWIERMNTIEAPNSGYVNRFYFESLYVPVSERILFEFATDGPGFASDEPYETLGEKLALPPFLEPKRAEIEKMVRPINTKRTEK
>NC_016011.1|WP_014092200.1|743638_744247_+|alpha/beta-hydrolase
MEHLFIPGKNKELAPLLLLHGTGGDEKSLVEVAEFIASDAPVLSLRGEIKEGGANRFFKRFHDGSLDLVDLESKTKDLIATTRELAEKYQLDFEKIIAVGYSNGANIAANALLQAENSFHKAILFHAMPAGNGQPAFSIDHRSVFLSAGLNDPLITAKASEQLVEILEKRGAKVETVWTAAGHSLTMEELEEAKKWYHKNEK
>NC_016011.1|WP_014092201.1|744255_744876_+|flavin-reductase-family-protein
MTSFKSADLTQKENYKFLTGSIIPRPIAFVTTLAEDGVTVNAAPFSFFNIVSSDPAIISIAVQRVEGEQKDTARNAAFTKELNIHIVSEEMVEEINKTAARLAPDVSEVADTNFHLANVPGMKTPKIAEAAIVLTAKLDRLVLVTNDAGKVVTDLLLARVLTYEFNDNVFDKEKEYILPEALAPVARLAGNDYSKLGEVFRLIRPN
>NC_016011.1|WP_014092202.1|745202_746459_+|GTPase-HflX
MEKKVLIVGVSQKQKDFDYSMEELANLAAANNMEVVGELRQNIDRENRATYVGKGKVDEVKGLAEMQDASLVIFNDELSPSQIRNLEEALELDVMDRTGLILAIFANRAKTKEAQLQVEIAKLQYELPRIFGQGEDMDQQSGKGGLSNRGSGEKKIETDRRTIKHQIRHLQKELAMLVDDREVRRRKRKKNEIPVVSLVGYTNAGKSTTMNGLVRAYSETADKQVFEKDMLFATLETSVREIVLPDNKQFLLTDTVGFVSKLPHQLVKAFRSTLEEARDADLLIHVVDYSDPHYKTMMQTTEETLKAVGVEDVPVIYAYNKADLLEDEIYPKQTENTIVFSAREQPSLEFLTEVIKKELFSGYEKSEFLIPFEAGQVVAYLNDHAKVLETEYLENGTKMVAEVSPVDLQKLKAYQVEQ
>NC_016011.1|WP_014092203.1|746535_747408_+|metallophosphoesterase
MKKTGWGILGAVVAFTGYAYWSTKHLTLTNYEIVSDKIPKEWNEARFVQLSDLHSASFGLYNNPLLSMVNEIAPDAVFLTGDILDGDESPVVAMALVRKLAKKFPTFYVSGNHEGRSAFYEDFKADIEAHQVTVLENERYFLKKDGAAIMVAGVQDPRFFKEDWVESELSKSEWEEEALTASLDEATSNLSADYFTILLAHRPEFWSLYQAYPVDLVLSGHAHGGQFRLPLTEGLFAPGQGFLPKWTAGIHRAAGKALIVSRGLGNVTKIPRLFNDPEVIQITLKAKGES
>NC_016011.1|WP_014092204.1|747412_748402_+|lipoate--protein-ligase
MIYLDNEDVLDQAYNFAMEEYALRFLDENETYFMFYRMKPTIIVGKNQNTLEEINQTFVEQHDVDVLRRLSGGGAVYNDEGNLSFSMITKDDGNSFQNFARFTEPVIHALQNLGMNAKLSGRNDIEIDGKKISGNAQFATKGRLYSHGTLLFDVDLSMLESALKVDPEKYLSKGVKSVRSRVTTIREHLTKDMDIQTFKQVLLESIFKTTDIPRYKFTETDKMGIEKLRIERYRNWDWTYGKSPKASMKRKKRFPAGTIEFQLELNKGQIKEAIIYGDFFGTEDVTELADRMIGCRYDRESIRKILQSIDAKDYFGHIEKEAIVDMLFE
>NC_016011.1|WP_014092205.1|748604_749357_+|hypothetical-protein
MAIKKLNDFYFKKLGNWNLIHSFMKGFWRTFFLLVLLLIVGDIVVIELMDSRFFIPAILLSLLCIPLFYYILIYTRAKKFIRVRYQLRNFSELTMMRRYLLFAYLEKSGFSTRDDLEKLLRFIHSEMAEEKKNDKPLNSVVGVFVATFLAILGGSFLFLVDNVVERLIAAVLIIVFAIILYAAGTFMMRVVRSKSEINKRKEHELTKEIIAIQTAMLVSENTSYHPFLAMEKKVSENDFLKEIITSRSFL
>NC_016011.1|WP_014092206.1|749378_750029_+|GntR-family-transcriptional-regulator
MTTKRKETRESVCYREIKKKIRNGELKPGDRLIENTLSKQLDISRTPIRKAIGMLAADGYVEYNDFRGAFVKDSIINKERYFEMTEILGLFLKQAIHKIRTKKISFNKLKATSKLAEIKCQEEQSDPAVYFDYEKWFVQDLLTYLKNNYYLKISEDFFSNIKEFGDEEVIKIAQNASVKTIDNIQNFIDALDVHDYDRCLKIIDDMIDAHVLVAYR
>NC_016011.1|WP_014092207.1|750075_751065_-|acryloyl-CoA-reductase
MKSFQALFIEKESETTSLQFREISLDTLPENEVTIEVHYSGINYKDGLAVLPDGKIVSEYPFVPGIDASGIVVETKTKRFQVGDEVIVTSYDFGVSYFGGYSEYIRVPAEWVVPLPAGLSLKEAMILGTAGFTAALSVDALEFSGVTPDAGKIAVSGGTGGVGSLSSAILSKRNYQVVASSSKADAKEFLQKFGVSEVVSREAFQPEKIRALDKQLFAGAIDCVGGKPLAYLLTAVQYGGAVTTCGMSAGGKLDTTVFPFILRGIQLFGIDSVLCPMPKRERIWRRLATDFQLANLEELATEIPFSELPNALHQVMNGGITGRYLVKIK

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Crispr_ID: NC_016011_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016011_4

2715689-2715868

Orphan

Consensus_repeat	Method
TATTATTACTAAGGTCTA	PILER-CR

2 spacers

The CRISPR arrays of NC_016011_4

>merge|NC_016011|4|2715689-2715868|PILER-CR
TATTATTCCTAAGGTCTAACCTCGTTAAATCTGCACTGGCACTAACATCTATACTAGTAAGATAATTATCAGCAAAATCAAGTGTCCTTAAGTCCGGATTATTACTAAGGTCTAGGTGACCAGTCAAGCTACCGTATTCTCCAAAAAAAGTAACTAGCTTAGTATTTTTACTAAGGTCTA

>NC_016011|4|3|2715689-2715868|PILER-CR
TATTATTCCTAAGGTCTA	ACCTCGTTAAATCTGCACTGGCACTAACATCTATACTAGTAAGATAATTATCAGCAAAATCAAGTGTCCTTAAGTCCG
GATTATTACTAAGGTCTA	GGTGACCAGTCAAGCTACCGTATTCTCCAAAAAAAGTAACTAGCTTAG
TATTTTTACTAAGGTCTA

Protein	Signature genes	Signature genes Name	Protein_function
NC_016011.1\|WP_014093850.1\|2727411_2728224_-\|membrane-protein	unknown	unknown	gnl\|CDD\|227242
NC_016011.1\|WP_003749772.1\|2724136_2724418_-\|PTS-sugar-transporter-subunit-IIB	unknown	unknown	gnl\|CDD\|99908
NC_016011.1\|WP_014093846.1\|2721714_2722767_-\|galactitol-1-phosphate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|176198
NC_016011.1\|WP_014093848.1\|2724474_2724939_-\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|334031
NC_016011.1\|WP_014093834.1\|2702861_2703572_-\|hypothetical-protein	unknown	unknown	unknown
NC_016011.1\|WP_014093839.1\|2712473_2712953_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NC_016011.1\|WP_003753951.1\|2705010_2706198_-\|elongation-factor-Tu	unknown	unknown	gnl\|CDD\|234596
NC_016011.1\|WP_003753956.1\|2708460_2708931_-\|30S-ribosomal-protein-S7	unknown	unknown	gnl\|CDD\|235398
NC_016011.1\|WP_014093847.1\|2722803_2724075_-\|PTS-galactitol-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|226298
NC_016011.1\|WP_014093849.1\|2724972_2727042_-\|BglG-family-transcription-antiterminator	unknown	unknown	gnl\|CDD\|226234
NC_016011.1\|WP_014093835.1\|2703558_2704344_-\|membrane-protein	unknown	unknown	unknown
NC_016011.1\|WP_014093844.1\|2720046_2720487_-\|ribose-5-phosphate-isomerase-B	unknown	unknown	gnl\|CDD\|376799
NC_016011.1\|WP_014093842.1\|2716672_2717317_-\|ribulose-phosphate-3-epimerase	unknown	unknown	gnl\|CDD\|238244
NC_016011.1\|WP_003720973.1\|2708961_2709375_-\|30S-ribosomal-protein-S12	unknown	unknown	gnl\|CDD\|235355
NC_016011.1\|WP_014093836.1\|2704409_2704817_-\|DUF2712-domain-containing-protein	unknown	unknown	gnl\|CDD\|371299
NC_016011.1\|WP_014093845.1\|2720681_2721713_-\|zinc-binding-dehydrogenase	unknown	unknown	gnl\|CDD\|176219
NC_016011.1\|WP_014093837.1\|2706307_2708395_-\|elongation-factor-G	unknown	unknown	gnl\|CDD\|234569
NC_016011.1\|WP_095075147.1\|2713000_2714572_+\|MucBP-domain-containing-protein	unknown	unknown	gnl\|CDD\|372554
NC_016011.1\|WP_014093843.1\|2719363_2720038_-\|ribulose-phosphate-3-epimerase	unknown	unknown	gnl\|CDD\|223114
NC_016011.1\|WP_014093838.1\|2711061_2712459_-\|deoxyguanosinetriphosphate-triphosphohydrolase	unknown	unknown	gnl\|CDD\|234897

Protein	Function_ID	Function_description	E-value
NC_016011.1\|WP_014093850.1\|2727411_2728224_-\|membrane-protein	gnl\|CDD\|227242	COG4905, COG4905, Predicted membrane protein [Function unknown].	1.11679e-123
NC_016011.1\|WP_003749772.1\|2724136_2724418_-\|PTS-sugar-transporter-subunit-IIB	gnl\|CDD\|99908	cd05566, PTS_IIB_galactitol, PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain that are expressed on three distinct polypeptide chains, in contrast to other PTS sugar transporters. The three genes encoding these subunits (gatA, gatB, and gatC) comprise the gatCBA operon. Galactitol PTS permease takes up exogenous galactitol, releasing the phosphate ester into the cytoplasm in preparation for oxidation and further metabolism via a modified glycolytic pathway called the tagatose-6-phosphate glycolytic pathway. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include galactitol, chitobiose/lichenan, ascorbate, lactose, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.	5.75607e-36
NC_016011.1\|WP_014093846.1\|2721714_2722767_-\|galactitol-1-phosphate-5-dehydrogenase	gnl\|CDD\|176198	cd08236, sugar_DH, NAD(P)-dependent sugar dehydrogenases. This group contains proteins identified as sorbitol dehydrogenases and other sugar dehydrogenases of the medium-chain dehydrogenase/reductase family (MDR), which includes zinc-dependent alcohol dehydrogenase and related proteins. Sorbitol and aldose reductase are NAD(+) binding proteins of the polyol pathway, which interconverts glucose and fructose. Sorbitol dehydrogenase is tetrameric and has a single catalytic zinc per subunit. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Related proteins include threonine dehydrogenase, formaldehyde dehydrogenase, and butanediol dehydrogenase. The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit. Horse liver alcohol dehydrogenase is a dimeric enzyme and each subunit has two domains. The NAD binding domain is in a Rossmann fold and the catalytic domain contains a zinc ion to which substrates bind. There is a cleft between the domains that closes upon formation of the ternary complex.	2.63141e-179
NC_016011.1\|WP_014093848.1\|2724474_2724939_-\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|334031	pfam00359, PTS_EIIA_2, Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2.	3.26718e-36
NC_016011.1\|WP_095075147.1\|2713000_2714572_+\|MucBP-domain-containing-protein	gnl\|CDD\|372554	pfam13306, LRR_5, Leucine rich repeats (6 copies). This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.	5.13143e-25
NC_016011.1\|WP_014093839.1\|2712473_2712953_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.58876e-10
NC_016011.1\|WP_003753951.1\|2705010_2706198_-\|elongation-factor-Tu	gnl\|CDD\|234596	PRK00049, PRK00049, elongation factor Tu; Reviewed.	0
NC_016011.1\|WP_003753956.1\|2708460_2708931_-\|30S-ribosomal-protein-S7	gnl\|CDD\|235398	PRK05302, PRK05302, 30S ribosomal protein S7; Validated.	2.46604e-105
NC_016011.1\|WP_014093847.1\|2722803_2724075_-\|PTS-galactitol-transporter-subunit-IIC	gnl\|CDD\|226298	COG3775, GatC, Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism].	0
NC_016011.1\|WP_014093849.1\|2724972_2727042_-\|BglG-family-transcription-antiterminator	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	2.63899e-86
NC_016011.1\|WP_014093842.1\|2716672_2717317_-\|ribulose-phosphate-3-epimerase	gnl\|CDD\|238244	cd00429, RPE, Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose phosphate pathway. In the Calvin cycle Ru5P is phosphorylated by phosphoribulose kinase to ribulose-1,5-bisphosphate, which in turn is used by RubisCO (ribulose-1,5-bisphosphate carboxylase/oxygenase) to incorporate CO2 as the central step in carbohydrate synthesis.	5.40743e-114
NC_016011.1\|WP_003720973.1\|2708961_2709375_-\|30S-ribosomal-protein-S12	gnl\|CDD\|235355	PRK05163, rpsL, 30S ribosomal protein S12; Validated.	8.80596e-88
NC_016011.1\|WP_014093836.1\|2704409_2704817_-\|DUF2712-domain-containing-protein	gnl\|CDD\|371299	pfam10916, DUF2712, Protein of unknown function (DUF2712). This family of proteins with unknown function appear to be restricted to Bacillales.	0.00251634
NC_016011.1\|WP_014093845.1\|2720681_2721713_-\|zinc-binding-dehydrogenase	gnl\|CDD\|176219	cd08258, Zn_ADH4, Alcohol dehydrogenases of the MDR family. This group shares the zinc coordination sites of the zinc-dependent alcohol dehydrogenases. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P)-binding Rossmann fold domain of an beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	4.44593e-172
NC_016011.1\|WP_014093837.1\|2706307_2708395_-\|elongation-factor-G	gnl\|CDD\|234569	PRK00007, PRK00007, elongation factor G; Reviewed.	0
NC_016011.1\|WP_014093844.1\|2720046_2720487_-\|ribose-5-phosphate-isomerase-B	gnl\|CDD\|376799	pfam02502, LacAB_rpiB, Ribose/Galactose Isomerase. This family of proteins contains the sugar isomerase enzymes ribose 5-phosphate isomerase B (rpiB), galactose isomerase subunit A (LacA) and galactose isomerase subunit B (LacB).	1.54989e-77
NC_016011.1\|WP_014093843.1\|2719363_2720038_-\|ribulose-phosphate-3-epimerase	gnl\|CDD\|223114	COG0036, Rpe, Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism].	3.2019e-93
NC_016011.1\|WP_014093838.1\|2711061_2712459_-\|deoxyguanosinetriphosphate-triphosphohydrolase	gnl\|CDD\|234897	PRK01096, PRK01096, deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional.	0

>NC_016011.1|WP_095075147.1|2713000_2714572_+|MucBP-domain-containing-protein
MYQTKKALTLVLSFQKFRNLSRGKNDRNLKLGGVIQLIKKIVWASFSLVLVLFSFPVVSTAATSGDFEYTVNGNEATITDYTGTITDVTIPATIGANNEYTVTSIGNGAFYSKGLTAVTIPDSVKTIGDGAFTINSLQQLVLPNSVQSIGINSFSVNQLETISLSTSLENIPRFAFLANKLKSVEIPANVTSIDASAFENNYITDITIQNPNIQLAYQAFAAQTILSKLIVPSDNTLPLKNYIHFNDASSQLTMDNLTVTDLADGVTYDSTKNALVFTAEPLESTFSLYTGTNRYDSYYDISEYGPSGKPIILFEYTKPVIATYKDETGTELASSTRIDGSIGDAYTSTPKTIDGFTLKETTGNPTGQFTNTTQNISYIYEKDPIQNGTVTVTYQDESGNSLVQDTTLTGEVGSTYQTESKNITGYQLTKVDGNESGTFSSNQTIVTYVYEKITSDENNSNGPGETTNNNSTNAEDADSPSTTTQMKASNSTLPKTSDSSDNFLFAVGGLLTALAMGILFFRR
>NC_016011.1|WP_014093839.1|2712473_2712953_-|GNAT-family-N-acetyltransferase
MSKLTFRNATEFDSALILHYILELAKHEGIGQDVVATEAGLRDTLFNQKVAEVIIAEYEDQSVGFALFFHNYSTLLGKKGLYLEDLYIIPEMRGKGFGTQFFKYLSKLALSRDCGRFEWWCLNENKSGMDFYNKIGAEKMAEWTVHRLSKIEMEKLSNL
>NC_016011.1|WP_014093838.1|2711061_2712459_-|deoxyguanosinetriphosphate-triphosphohydrolase
MKWDKLLNDKRRRESGVTRSKNTDVRSAFENDFQRIVMSASFRRLQDKTQVFPLEKSDFVRTRLTHSMEVSTIAKSMGNMVTHTIQEEKLDEDFTKDHADKIPEILACAGLLHDMGNPPFGHFGEESIREWFRDNLATITYKNKSLAEILTPQMKEDFYYFEGNAQVLRVVSKLHYLFDQYGLNLTFATINAVIKYPVSSLKINKNQIKSKKLGYFYADESLFNEITTATEALDNRHPLTYLLEVADDIAYLNADLEDGVKKGIVNITQILRGFEEIEEHNKVTAACYNELKKKSERYEGQEESFIVQQWLASNVRGQLINRSLEVFYANYEAIMAGTFNDSLIDASEAEQLVQILQSLSFTYIYQDKGIVESEIAGNEIISKLLETFIPAVIYYDSETPERQTAKDKRLLTLISDNYLGCYRKNAEGESETMKLYLRLLLVTDFICGMTDSYAKDLYQRLNGLS
>NC_016011.1|WP_003720973.1|2708961_2709375_-|30S-ribosomal-protein-S12
MPTINQLVRKPRQSKIKKSTSPALNKGLNSFKRELTDVNSPQKRGVCTRVGTMTPKKPNSALRKYARVRLSNGIEVTAYIPGIGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGALDTAGVENRGQSRSKYGTKKPKK
>NC_016011.1|WP_003753956.1|2708460_2708931_-|30S-ribosomal-protein-S7
MPRKGPVTKRDVLPDPIYNSKLVTRLINKMMVDGKRGKSQAILYSAFDIIAQETGKDPMEVFEQAMKNIMPLLEVKARRVGGANYQVPIEVRADRRSTLGLRWLVNYARLRGEKTMEVRVAREIMDAANNTGASVKKREDTHKMADANRAFAHYRW
>NC_016011.1|WP_014093837.1|2706307_2708395_-|elongation-factor-G
MAREFSLEKTRNIGIMAHIDAGKTTTTERILFYTGRIHKIGETHEGASQMDWMEQEQERGITITSAATTAQWKGYRVNIIDTPGHVDFTVEVERSLRVLDGAVAVLDAQSGVEPQTETVWRQATTYGVPRVVFVNKMDKIGADFLYSVGTLHERLAANAHPIQLPIGAEDTFEGIIDLIEMNALYYEDDLGNDPHIKEIPADLKELADEYRGKLVEAVAELDEELMMKYLEGEEITKEELKAGIRKGTLNVEFYPVVCGTAFKNKGVQPMLDAVLDYLPAPTDVPAINGVLPDGEEAARHADDSEPFSSLAFKVMTDPYVGRLTFFRVYSGTLNSGSYVQNSTKGKRERVGRILQMHANHREEISIVYAGDIAAAVGLKDTTTGDTLCDEKDQIILESMEFPEPVIQVAIEPKSKADQDKMGQALAKLAEEDPTFRAETDQETGQTLISGMGELHLDILVDRMRREFRVEANVGDPQVSYRETFRKSAQVEGKFVRQSGGRGQYGHVWIEFGPNEEGKGFEFENAIVGGVVPREYIPAVQAGLEGALDNGVLAGYPLIDIKAKLYDGSYHDVDSNEMAFKVAASMALRNAAKKCDPVILEPMMAVEVVIPEEYLGDIMGNITSRRGRVDGMEARGNAQVVRAFVPLANMFGYATHLRSGTQGRGVYTMQFDHYEEVPKSIAEEIIKANGGNNKED
>NC_016011.1|WP_003753951.1|2705010_2706198_-|elongation-factor-Tu
MAKEKFDRSKPHVNIGTIGHVDHGKTTLTAAITTVLAKKGFADAQAYDQIDGAPEERERGITISTAHVEYQTDTRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAADGPMPQTREHILLSRQVGVPYIVVFMNKCDMVDDEELLELVEMEIRDLLTEYEFPGDDIPVIKGSALKALQGEADWEAKIDELMEAVDSYIPTPERDTDKPFMMPVEDVFSITGRGTVATGRVERGQVKVGDEVEVIGIEEESKKVVVTGVEMFRKLLDYAEAGDNIGALLRGVAREDIQRGQVLAKPGSITPHTNFKAETYVLTKEEGGRHTPFFNNYRPQFYFRTTDVTGIVTLPEGTEMVMPGDNIELAVELIAPIAIEDGTKFSIREGGRTVGAGVVSNISK
>NC_016011.1|WP_014093836.1|2704409_2704817_-|DUF2712-domain-containing-protein
MKKKLVVLGLAGAMFLSGMGILNVSAANYSDTKFSFTLGRLGGNDYTSARQKQNTTASYVKLNSIGKGTMDAWILKSNGASVRSREVTVSQGKSKKIANYAYEDYGKCNVKLAAETSKLQIVRVSATGLWSPDSI
>NC_016011.1|WP_014093835.1|2703558_2704344_-|membrane-protein
MNQFLKIEFKRVFKNKSFLLALALGMFIVIIQQITVARYYSPTEENVFIYLTGYNTTGLGTNLYYLLLPCLVALAGADLLGEDRRTGLDIFSRIRGTDKQYYFSKSIVAFVAGGVAFCLPLIVELFLLMLVYPSVPFDYFASEVPVTYEEMFGNVFYNSPITYEVIFLVIGFVYSGLFALLGILVSFFSSSKYVVLLSPLAIYYGIWIVFSLGGYPEVSPFGFLTPKQAYPLNFQVIWIEFLLLFVVAIIGIAWSVKNEKS
>NC_016011.1|WP_014093834.1|2702861_2703572_-|hypothetical-protein
MKSHNLIRSNFDFKKRKYLLLLLLCIFIIIIRLWYTGNIGMDVLSTVQSSVSVEVLFMILSPFCLWLNQVLYFQNREFAVVRVKNKYNLWKVNATVIFWNAFLIAIMNSILSFGSSMLNREIAISAQMLQLYIYSFILFLLGLILIGILQNILIVLTENKAIAFFLVFLVFLFDISTIKLQKVSNLFVVNDRDLIDLYSFAGRVLCLISVLIVLFWINWFLMEKKDMFRTSKKKVR
>NC_016011.1|WP_014093842.1|2716672_2717317_-|ribulose-phosphate-3-epimerase
MTFVAPSLLAADYMNMANSIKEAELAGADYLHIDVMDGHFVPNLTFGIDMVAQIAKTATIPLDVHLMLANPENYIEKFANAGAHIISVHIEATPHIHRVIQQIKQAGCKAGVVLNPGTPANALDSILGDVDLVLQMTVNPGFGGQSFIPTTVENLRYLDNWRRNHRANYVIEVDGGINEASAERCKQAGVDILVAGSYFFRSQEKTACIQILKS
>NC_016011.1|WP_014093843.1|2719363_2720038_-|ribulose-phosphate-3-epimerase
MRKIAASIMCADQLHLGDELKRLESAGVELLHCDVMDGVYVNNLALGPEYLEIVRNNTEIPLDIHLATITPLKYIDMFGPVKPEYISFHAEVADDVTEVIRKIRSYNVKPSIAINPETPIEAIYPYLNDVEMVLMMTVNPGFAGQKFQTNVLQKLRDLKAKLAGKVHVPLIEVDGNINKETVGLMRDCLPDIYVLGTSALFHDRDKTSYSERLVHIWSDVEKHV
>NC_016011.1|WP_014093844.1|2720046_2720487_-|ribose-5-phosphate-isomerase-B
MKLTIGCDHGGRRLKDAIVKHLREKNIEVVDIGTYTDDSVDFPSYAEEVANQVVSGQSELGILCCGTGIGMSIAANKVDGIRAAVVSDTFSARATREHNNSNVLCLGERVIGEGLALLIVDTWLEATFAGDRHKRRLDKITELERK
>NC_016011.1|WP_014093845.1|2720681_2721713_-|zinc-binding-dehydrogenase
MKAVVKTNPGYDQMELKDVEEPQAYGDKVKIKVAFTGICGSDIHTFKGEYKNPTTPVTLGHEFSGVVVEVGPDVTSIKVGDRVTSETTFETCEECIYCKERDYNLCSNRRGIGTQANGSFAEFVLSREESCHVLDERISLEAAALTEPLACCVHSALEKTTIRPDDTVLVFGPGPIGLLLAQVVKAQGATVIMAGITKDSDRLLLARELGIDRIVDTLKEDLAEVVFGMTDGYGAERVFDCSGAVPAVNQGLPLTKKKGDFVQVGLFAEKKNAIDEESIIQREIAYIGSRSQKPSSWILALDLLANGKINTDKMITKVYGLDDWREAFEAVMAGNEIKVLVKS
>NC_016011.1|WP_014093846.1|2721714_2722767_-|galactitol-1-phosphate-5-dehydrogenase
MRAAVLYENNVIKAEQIDEAICGKDEVRVEVKAVGICGSDIHKMQTRWKYPLPAVMGHEFAGVITEVGSEVENRAIGDRVAGIPLEPCMECNYCKAGDFSLCDNYRMVGSHFHGGFAENVVMKADNVISIGDLDFEEGAMIEPLAVSMHGVLGIEPRLGDTAIVFGIGTIGILVVQCLLLAGVKDIIAVDISDKKLADAKEFGCRYTINPKNEDLKERTLAYTNGLGADIALECAGSKITQEQCLLVTKKKGKVGFLGIAYADVLLHEEAFENIFRRELTLKGFWNSYSAPFPGEEWRTSIEFVKQGRIKLKPLISHRYKLEETKEAFEMILSREHDYNKVMILPQKGDD
>NC_016011.1|WP_014093847.1|2722803_2724075_-|PTS-galactitol-transporter-subunit-IIC
MDTLLAGVQYVLNLGPTVILPIMIFFIALIFRVPAKKALRSAITIGIGFVGINLVISLLSSNLGPAAQQMVERFGLNLTIIDAGWPAAAAASWASPVAAILIPICLAVNLALIFFKVTKTLDIDIWNYWHFIAAGATGYIVTGGNWWFAILCAIIYEVAVLWMADRTQPMVEEFYGLKGISLPTGSTAAFGFIGIPVGWLIAKIPGIKNIHVDPETIQKRFGIFGEPMMMGLILGIAIGLLAGYDVGAVAQLGMSMGAVMFLMPRMVKILMEGLIPISESAREFMKSRFKGRELYIGLDAALSIGHPANISTGLILVPITLFLAVIIPGNKVLPFGDLATIPFYVSFVVASRKGNILHSVLAGTVVIALALLMATDFGLVHTEMMKGVYEFPKGATQVSTLDMGGNFFNWVILKFSQAWAAIF
>NC_016011.1|WP_003749772.1|2724136_2724418_-|PTS-sugar-transporter-subunit-IIB
MGQFKILVACGAGIATSTVVTDRVERLVKEHNVDAEVKQIKISEAASMQDGADLIVSTTILPTTYKIPAIIATSYITGMGMEELDEEILAHLK
>NC_016011.1|WP_014093848.1|2724474_2724939_-|PTS-sugar-transporter-subunit-IIA
MDLVQFLKKGMVWVQSDIDKQEDLFQMVAESGKSEGYVTDDFLTRLTDREQTFPTGLKLDGYGVALPHTDPECVTEQFIAVITVKDGIPFKLMEDAGQTVEANLIFVLGLNEPHSQLAVLQQLMGTIQDKDNVTALLRAKDEAEVKQILETITV
>NC_016011.1|WP_014093849.1|2724972_2727042_-|BglG-family-transcription-antiterminator
MYLDERSNSLLKELLRHPDTSSINLQAKFGLTRRQVDYSFQKINNWLEEQTYPKIHRAANGRFIVEPDLFQIIGEEDGEKTDWYIPSEKERASLIILMLTTGSEELSLNHFISELEVSKNTVLRDLKLVQKTLDKFNLEVKYSRMRGYLIDGDEWNQRTALIYAAEHIIESFGGEEYLQDFMQVEEARIKELREKLEQVEHHLNLHFIDNKMQILPYILEAVFRRMKKGQTITTSFLIDYNELSDTREYGAAEILIEEEPNMPEAERMYITLQLLTSNVLPKQYLKSEETHKLRLALEQVLSEFEKKACIQLVDKESLLEKLFAHIKPAYYRIKYHLTTDYSILDKIDQEFQAVHYIVKESLVPLERFIGSKVPENESIFITLFIGGHLIESTEKLQTRLKAVVVCPNGLSISRLMEKTLRSLFPEIFFYQAMSIREFEQTKVGYDIVFSAVPLSTDKKFFLINQLMDGKERLELRRRVMRSVYLVDEVNISVDQLMKTISKFADIKDAARLEKVLADYLMPVPEETTSTSSTKSSLADLLEGTRITRKKSVENWHEAIHHAASPLLSAGVVEERYVAEMKRQYPAPIMNIILRNTIAIPHAETEKGVKSLGMSLLYLEEGLPVEGGKNLHFIVVIAAVDKNAHFTALLQLMELSENKKVLKKLADAGNTEEMHQIIKNFTDLETKKTM
>NC_016011.1|WP_014093850.1|2727411_2728224_-|membrane-protein
MDINMFILYFFIYSVLGWAWEEVFCSISEKKLVYRGFLYGPYCPIYGFGVTSVLMLILPFQNNLWALFIFSIVICTVIEYVTATILEALFHTTWWDYHEWPLNVKGRICLPISIFWGFACIIVVRFLHPLVTEFADWILSWGGWIVPALIVVIMLIDTIKSVTSMLSFQKALAEFNEKLNAQADELKASVKERAKEFEEGLLKKQENIDMKIAEVEAKRKQDAELAASMRKLKFNERRMLKSFPKMKVRHSSSFKNFNKSLLRVDKQKRK

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Crispr_ID: NC_016011_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016011_5

2798087-2798199

Orphan

Consensus_repeat	Method
AACGCGAGGATTTAATCCTTCGTGGAAGTTTCAAAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_016011_5

>merge|NC_016011|5|2798087-2798199|CRISPRCasFinder
AACGCGAGGATTTAATCCTTCGTGGAAGTTTCAAAACGTTCTTTGTTTTGATTTACTTCTTCAATATAGATCCGAGTAACGCGAGGATTTAATCCTTCGTGGAAGTTTCAAAA

>NC_016011|5|4|2798087-2798199|CRISPRCasFinder
AACGCGAGGATTTAATCCTTCGTGGAAGTTTCAAAA	CGTTCTTTGTTTTGATTTACTTCTTCAATATAGATCCGAGT
AACGCGAGGATTTAATCCTTCGTGGAAGTTTCAAAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_016011.1\|WP_014093906.1\|2789258_2789996_-\|HAD-family-phosphatase	unknown	unknown	gnl\|CDD\|223635
NC_016011.1\|WP_014093914.1\|2798947_2799169_-\|hypothetical-protein	unknown	unknown	unknown
NC_016011.1\|WP_014093913.1\|2798741_2798945_-\|DUF3188-domain-containing-protein	unknown	unknown	gnl\|CDD\|371501
NC_016011.1\|WP_014093904.1\|2787542_2787860_-\|PTS-lactose/cellobiose-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|376749
NC_016011.1\|WP_014093909.1\|2794114_2794834_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225099
NC_016011.1\|WP_014093905.1\|2787852_2789262_-\|glycoside-hydrolase-family-1-protein	unknown	unknown	gnl\|CDD\|225343
NC_016011.1\|WP_014093908.1\|2793662_2793959_-\|transcription-antiterminator	unknown	unknown	gnl\|CDD\|99906
NC_016011.1\|WP_014093911.1\|2796243_2797977_-\|DNA-polymerase-III-subunit-gamma/tau	unknown	unknown	gnl\|CDD\|235505
NC_016011.1\|WP_014093907.1\|2792284_2793637_-\|PTS-sugar-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|224372
NC_016011.1\|WP_014093916.1\|2801112_2801277_+\|hypothetical-protein	unknown	unknown	unknown
NC_016011.1\|WP_014093922.1\|2805895_2806831_-\|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	gnl\|CDD\|273478
NC_016011.1\|WP_003754045.1\|2794934_2795177_-\|YaaL-family-protein	unknown	unknown	gnl\|CDD\|378478
NC_016011.1\|WP_014093915.1\|2799302_2800667_-\|PTS-sugar-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|224372
NC_016011.1\|WP_014093910.1\|2795191_2795788_-\|recombination-protein-RecR	unknown	unknown	gnl\|CDD\|234616
NC_016011.1\|WP_014093918.1\|2801936_2802578_-\|hypothetical-protein	unknown	unknown	unknown
NC_016011.1\|WP_014093912.1\|2798280_2798745_-\|DUF3284-domain-containing-protein	unknown	unknown	gnl\|CDD\|378692
NC_016011.1\|WP_014093921.1\|2804910_2805852_-\|GW-domain-containing-glycosaminoglycan-binding-protein	unknown	unknown	gnl\|CDD\|226309
NC_016011.1\|WP_014093920.1\|2803283_2804798_-\|gluconokinase	unknown	unknown	gnl\|CDD\|212659
NC_016011.1\|WP_003754047.1\|2795896_2796214_-\|YbaB/EbfC-family-nucleoid-associated-protein	unknown	unknown	gnl\|CDD\|234669
NC_016011.1\|WP_014093917.1\|2801427_2801901_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_016011.1\|WP_014093906.1\|2789258_2789996_-\|HAD-family-phosphatase	gnl\|CDD\|223635	COG0561, Cof, Predicted hydrolases of the HAD superfamily [General function prediction only].	6.72242e-33
NC_016011.1\|WP_014093922.1\|2805895_2806831_-\|LPXTG-cell-wall-anchor-domain-containing-protein	gnl\|CDD\|273478	TIGR01167, Zinc_metalloprotease_ZmpB, LPXTG-motif cell wall anchor domain. This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region. [Cell envelope, Other].	3.5553e-05
NC_016011.1\|WP_014093913.1\|2798741_2798945_-\|DUF3188-domain-containing-protein	gnl\|CDD\|371501	pfam11384, DUF3188, Protein of unknown function (DUF3188). This bacterial family of proteins has no known function.	1.88527e-10
NC_016011.1\|WP_014093904.1\|2787542_2787860_-\|PTS-lactose/cellobiose-transporter-subunit-IIA	gnl\|CDD\|376749	pfam02255, PTS_IIA, PTS system, Lactose/Cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The lactose/cellobiose-specific family are one of four structurally and functionally distinct group IIA PTS system enzymes. This family of proteins normally function as a homotrimer, stabilized by a centrally located metal ion. Separation into subunits is thought to occur after phosphorylation.	3.77767e-27
NC_016011.1\|WP_014093909.1\|2794114_2794834_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	8.11967e-70
NC_016011.1\|WP_014093905.1\|2787852_2789262_-\|glycoside-hydrolase-family-1-protein	gnl\|CDD\|225343	COG2723, BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase [Carbohydrate transport and metabolism].	0
NC_016011.1\|WP_014093908.1\|2793662_2793959_-\|transcription-antiterminator	gnl\|CDD\|99906	cd05564, PTS_IIB_chitobiose_lichenan, PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-diacetylchitobiose-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain. In the chitobiose system, these subunits are expressed as separate proteins from chbA, chbB, and chbC of the chb operon (formerly the cel (cellulose) operon). In the lichenan system, these subunits are expressed from licA, licB, and licC of the lic operon. The lic operon of Bacillus subtilis is required for the transport and degradation of oligomeric beta-glucosides, which are produced by extracellular enzymes on substrates such as lichenan or barley glucan. The lic operon is transcribed from a gammaA-dependent promoter and is inducible by lichenan, lichenan hydrolysate, and cellobiose. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include chitobiose/lichenan, ascorbate, lactose, galactitol, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.	1.79037e-26
NC_016011.1\|WP_014093911.1\|2796243_2797977_-\|DNA-polymerase-III-subunit-gamma/tau	gnl\|CDD\|235505	PRK05563, PRK05563, DNA polymerase III subunits gamma and tau; Validated.	0
NC_016011.1\|WP_014093907.1\|2792284_2793637_-\|PTS-sugar-transporter-subunit-IIC	gnl\|CDD\|224372	COG1455, CelB, Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism].	1.52776e-76
NC_016011.1\|WP_003754045.1\|2794934_2795177_-\|YaaL-family-protein	gnl\|CDD\|378478	pfam10704, DUF2508, Protein of unknown function (DUF2508). This family is conserved in Firmicutes. Several members are annotated as being the protein YaaL. The function is not known.	1.87825e-14
NC_016011.1\|WP_014093915.1\|2799302_2800667_-\|PTS-sugar-transporter-subunit-IIC	gnl\|CDD\|224372	COG1455, CelB, Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism].	4.26294e-160
NC_016011.1\|WP_014093910.1\|2795191_2795788_-\|recombination-protein-RecR	gnl\|CDD\|234616	PRK00076, recR, recombination protein RecR; Reviewed.	1.8956e-130
NC_016011.1\|WP_014093912.1\|2798280_2798745_-\|DUF3284-domain-containing-protein	gnl\|CDD\|378692	pfam11687, DUF3284, Domain of unknown function (DUF3284). This family of proteins with unknown function appears to be restricted to Firmicutes.	6.21397e-28
NC_016011.1\|WP_014093921.1\|2804910_2805852_-\|GW-domain-containing-glycosaminoglycan-binding-protein	gnl\|CDD\|226309	COG3786, COG3786, Uncharacterized protein conserved in bacteria [Function unknown].	1.00275e-93
NC_016011.1\|WP_014093920.1\|2803283_2804798_-\|gluconokinase	gnl\|CDD\|212659	cd07770, FGGY_GntK, Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases. This subfamily is composed of a group of gluconate kinases (GntK, also known as gluconokinase; EC 2.7.1.12) encoded by the gntK gene, which catalyzes the ATP-dependent phosphorylation of D-gluconate and produce 6-phospho-D-gluconate and ADP. The presence of Mg2+ might be required for catalytic activity. The prototypical member of this subfamily is GntK from Lactobacillus acidophilus. Unlike Escherichia coli GntK, which belongs to the superfamily of P-loop containing nucleoside triphosphate hydrolases, members in this subfamily are homologous to glycerol kinase, xylulose kinase, and rhamnulokinase from Escherichia coli. They have been classified as members of the FGGY family of carbohydrate kinases, which contain two large domains separated by a deep cleft that forms the active site. This model spans both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. Some uncharacterized homologous sequences are also included in this subfamily. The Lactobacillus gnt operon contains a single gntK gene. The gnt operons of some bacteria, such as Corynebacterium glutamicum, have two gntK genes. For example, the C. glutamicum gnt operon has both a gluconate kinase gntV gene (also known as gntK) and a second hypothetical gntK gene (also known as gntK2). Both gluconate kinases encoded by these genes belong to this family, however the protein encoded by C. glutamicum gntV is not included in this model as it is truncated in the C-terminal domain.	0
NC_016011.1\|WP_003754047.1\|2795896_2796214_-\|YbaB/EbfC-family-nucleoid-associated-protein	gnl\|CDD\|234669	PRK00153, PRK00153, YbaB/EbfC family nucleoid-associated protein.	1.23532e-40

>NC_016011.1|WP_014093911.1|2796243_2797977_-|DNA-polymerase-III-subunit-gamma/tau
MAYQALYRVFRPQSFQDVVGQEHVTKTLKNAIVQNKTSHAYLFSGPRGTGKTSAAKIFAKAINCEHGHDGEPCNECDICKGTTDGSIPDVLEIDAASNNGVEEIRDIREKVKYAPTVAKYKVYIIDEVHMLSTGAFNALLKTLEEPPKHVIFILATTEPHKLPLTIISRVQRFDFKRITTQDIIGRLEFILKEEKTPYDEKALMIVARAAEGGMRDALSLLDQVISYGSEEVTVDDALEITGSIAQGLLTKLVSAAFDGDAAEAISTLTALLAEGKDPVRLVEDLLVFFRDVLLYQKAPNLEETLERALIDDEFVSLAKRANSFKIYEFVKILNTAQQQMRFSNHPGIYVEVALVQLTQAGQTVGESAAPVEVASGDVSALKQQMEQLQLELQTLKKQIASGAGVAPTEKPAQNRGGSKKQINNGKQFKAPIGKINHVLGEAKKENLQLIRGCWGELLSMLMASQAALLNDAEPVAASLDTFVLKFKHEIHCQMAMDNPNFVETITSSIAKLTQVNYTFIGIPEDQWAEVRENFLHSHVGNGDSEEGANPEARKPAEDPFVLEATKLVGEDLLEIKD
>NC_016011.1|WP_003754047.1|2795896_2796214_-|YbaB/EbfC-family-nucleoid-associated-protein
MRGMGNMQGMMKQMQKMQKEMAKAQADLEVQEFTGTAGGGMVTVKATGKRVITDVVINEEVVDPEDIEMLQDLVLAATNDVLKQIEDTTSQTMGKFTQGLNLPGM
>NC_016011.1|WP_014093910.1|2795191_2795788_-|recombination-protein-RecR
MHYPEPITKLMDSFMKLPGIGPKSAARLAFYVLDMKEDDVLDFAKALVDAKRNLSFCSVCGHITDKDPCYICADTSRDRSIICVVQESKDVIAMEKMRDFHGLYHVLHGTISPMDGIGPEDINIPDLLKRLQDDTIEEVILATNPNVEGEATAMYISRLLKPSGIKITRIAHGLPVGGDLEYADEVTLSKAMEGRREV
>NC_016011.1|WP_003754045.1|2794934_2795177_-|YaaL-family-protein
MESRSNKFGRKKEKKIGKLHKSYDAYLMELIEVTQENWHKQKVLLRKSFEYDPNLEYEEKKAEARYFYLFKEARKRQLKK
>NC_016011.1|WP_014093909.1|2794114_2794834_-|GntR-family-transcriptional-regulator
MSTKILKYETIAFDLRKKILSGFYKQNDQLPLEKEMCEEYDTSRITVKKAMDQLVLEGLVVKRRGAGTFVKDVENPDADVLQSMQFMGFSEENKHRNVSSDILKFEIINPDESTLNKLRISELDFVYHIIRVRKIDKKPHAIEECFMPINLISGLRMDIVASSIYTYIESVLGFSIQSAHKTVSAMMPTEFEKEYLKIADVSPILNIEQVAYLDNGQPFEYSNTKYRADKYEFHAINIR
>NC_016011.1|WP_014093908.1|2793662_2793959_-|transcription-antiterminator
MKISLFCNAGMSTSLVASKLKKAYLERGITYDVEAFDFSALQEEADETDVIILGPQIAWAFDDVTKDYPDKKVIQLTMAEFGSMDGEKVLERVEKELN
>NC_016011.1|WP_014093907.1|2792284_2793637_-|PTS-sugar-transporter-subunit-IIC
MASEKLNKFQMKLTKIMGKIAGNKLLLSLRDTFIMAAAPLMIAGFAIMISSVFLDPTGIIFGNSGLHLGSLISGSEKAFLVSDFANNLRTLQGYFNLFINGTMAINALLVVAGFAFFGSRRFFPKNKEPIVVTFYALAGFFITLPWTVTTLDTKGKEVTINGIVNSNFIGQQGIFTGLIVSGITIYVFNKLIQKNVTFKMPDTVPPAVAKSFESLVPGVVTLAIFVIVAGVLNGVFDTSLPEALLWLLQKPALAVAATPLFAVVAIVSTPILQWFGIHGTSVWGPIFGLTWNINDNENIMGTAQHLYSTLFMNFTVVSSGALTLAPIIAIIIFSKRADNKKIAKLAIAPGIFNVSEPVTYGLPIVLNPILFIPYLLSWVIPFFLGQLLTEIGLIPIITNNVPWTVPPILSGLLYSGSIMGALYQALVIVIVVILYMPFVRVANNLANKLD
>NC_016011.1|WP_014093906.1|2789258_2789996_-|HAD-family-phosphatase
MTKKLFVTDLDGTLVTRNNEIELADLHAIRSWQQQGNLWAVATGRKWDSVVELLQRYDLAADALILENGALILASSGEVIWQKNIQTETAKQVTNFDLSLVEEVCLVTSFNQATPQQLLNLASFKETQAISAITLRYATADLAEEYVNQVEALITDAVFRNMNYIDIAPNGCSKGAAVKFLMERFMLTKNEVSVIGDSFNDISMFEVSSHPFTLEHAEKAMHEQGALVVKNVHEAINKVRLEWDF
>NC_016011.1|WP_014093905.1|2787852_2789262_-|glycoside-hydrolase-family-1-protein
MTKQIEFPKGFYWGSAASATQTEGAAHEGGKGENIWDYWYKTQPKRFYEKVGPEKASEFYDNFRSAIKLLSQTGHNSFRPSISWSRMFPNGFGEVNPEAVRFYNEVIDALIEEGVEPIMNLYHFDMPLAMQEIGGFENKEVVEHYVAYATTCFRLFGDRVKRWFTFNEPIVPVEGGYLYDFHYPNKVDPKAAAQVAFNTLLASAKAIEAYHKISDGKIGIVLNLTPSYPRSDNPADMEAARIADIFCNKSFLDPAVLGKFPEGLKEILARHDCLPVYSEEELAIIERNTIDFLGVNYYQPRRVCARDTLPNPDAPFMPEFYFQNYEMPGRRMNVYKNWEIYEQALYDVAINIRDNYGNIEWMVSENGMGVKDERRFAKGDYIEDDYRIEFFEDHLYWLNKGILEGSNCIGYHVWTFIDNWSWMNAYCNRYGLVSLNLATGNRTIKKSGEWFKALHDNNGFSYEGVLPYE
>NC_016011.1|WP_014093904.1|2787542_2787860_-|PTS-lactose/cellobiose-transporter-subunit-IIA
MNDKESQIAMELIFHSGNAKSTAMQAIIKAESDNIAEGKELIKQARKELHEAHAIQTNLMTAEINGEEIEKTILLIHAQDHFMAANLTIDLGERMITLYEKIANK
>NC_016011.1|WP_014093912.1|2798280_2798745_-|DUF3284-domain-containing-protein
MNVTQKLYISQKECFDTIVSSAIYDVKNATGKTVQRHKLEGHKYQRTMSNGALATTKIVQVKPYELYQFETSSRVNTHTTTYTIKSTSETTCEVTYNELIETEKTLNKMNNIIVGFMFGFFRKKRVKNLLKSIELSVINESKKKQEKSAAKSEQ
>NC_016011.1|WP_014093913.1|2798741_2798945_-|DUF3188-domain-containing-protein
MKIVNALFIISIGLIIIMFSPAYGKDGMASVPILVTGLVVVLIGCLFIVLKLRKDKKEKNKKESIEK
>NC_016011.1|WP_014093914.1|2798947_2799169_-|hypothetical-protein
MIILNCPMKRDYITELLETHDKDGITLKKISEQGMKLTFETNIEDEEKAAKIAKETIKATEIGSVLYFQVSVG
>NC_016011.1|WP_014093915.1|2799302_2800667_-|PTS-sugar-transporter-subunit-IIC
MNGLTAFLEKYFVPVAAKIGSQKHLVALRDAFISTMPITMAGSIAVLLNAFFRDFPTDWGWTGFVSAMQPLIEVNGYVYNGTLAIVSIIFAFSLGYNLSKVYEVDRLAGGLVSLAAFVMNLTVTVSLDAVKAAIAASNANFDVNTLPKEFAGIYGFFSLSQVNGTGLFTAMIFGFISTIIYAKLMRRNIIIKMPDTVPPAVSKAFAAIIPALVALYVVGIIDWAFFKVTNMDVITWISKTIQEPLLSLSQGYGAVLLVTFLVQLLWFFGIHGPNVLAPVLESLWGTAQLQNISAAQEGVKLPFEWVRGSFDAYVWMGGSGGTLVLIIALLMFSKRADARTVAKLSLAPGIFNINEPIMFGLPIVLNTIYLIPFIIAPMIMVTIAYFATTLGLVGPVKIAVVWVMPPLLNSFLATGGDWMAPVISLINMVVAFLIWVPFVITANRVGVPEEEMKA
>NC_016011.1|WP_014093916.1|2801112_2801277_+|hypothetical-protein
MAVKRDMPEESKNSKVVKKEHFSIVFPDDIKVPKSEKELEAEKAENKSEHDKTN
>NC_016011.1|WP_014093917.1|2801427_2801901_+|hypothetical-protein
MNQDLRLPQNNKEGLLYGVIICSITAFLMTTFNTYLQIRIVNADFLLTIVKLFPLFFIVAMLLENFIISHFSRKMVTKYMDASDSFNAYILFSVLFTVLGMSFCMTFIGDFIGHGFVIEEGLLSRFFSIWPRNFAIVLFIELIIAQPLARNVMSILH
>NC_016011.1|WP_014093918.1|2801936_2802578_-|hypothetical-protein
MQQLKTKKKWLPALIVAVLVGVLVILAIMFGFFQRQEVFDKYDVAYEIDGKLYEVFPISTTDIGVDKKSDDKHFYFRVNSYYNIDYLFRLAYKQYEINEPSTNKYYSGLIDYSVADNAYVTQKDIYMTKDESYATYDFFDKTGKKIYTYNPEETSTDDYIVRIKPTILQGYKKSDIGSYDDYLDITALFKDKLGMDVKVRIDDDKKMVIFSIK
>NC_016011.1|WP_014093920.1|2803283_2804798_-|gluconokinase
MTSESYIMGVDIGTSSTKAVLFNEQGEVIYREAAHYELVTDETGKAEESPTEIFEAVITSIRRVMNKIDKADLRGISFSSAMHSLILAKSNGELLTECITWADGRSSEALENVKRDNYLFQLYETTGTPIHPMSPFAKICWLKEAEPELFNRAEKFVDIKAYILYRFFDVWVMDESLASGTGLYNISEHDWEFEAIEIVKLTPDFLPKVVPETYQLSGIKTEYAEMMGIPTSVPFIVGGSDGALANIGIQATGQSDVTITVGTSGAVRKLTTEFQVDSRGRTFCYGAGDGYFIAGGAVNNGGKVVEWGLNQFGSESEIKNRDFASFIAHIDEVDPGAAGLLFQPYLLGERAPFWTNDIRGGFVGLTINHTKAHFIRAILEGIAFNLAEVYEAVSAPDDIIYVTGGISAHEGWCKLLADILDREIRVPHTIEGSSLGAAIIGMRSLGILKDLNLKQTSPIKATYYPSKNTERYTELRLIFKQVSTQLLSSYSQLNSWQKKFENNS
>NC_016011.1|WP_014093921.1|2804910_2805852_-|GW-domain-containing-glycosaminoglycan-binding-protein
MKKLLSGLIIVVMISLLGNSFTAEAATYDKIIYDKAVNLKGVVNQSKRNDGIRSKMYNVSSDSKLLGYAKKYDKKTLIITREGKTSRGAKWYYVKLGNTNIGWIDALAFKNVGKPTIADTVPALWNSKKAIITTKPKSTSATTYLFQRNSAGNWYEVRDFTSHIGKWGFDPNFSEKSSGTPVGVYRTGLAFGQKGNPGTKLTFKAITNRSYWISNSNDKAYNTWQERSSSSSADEKMKIPQYKYGMEVKYNSKRIKGKGSAVFYHIDSPHYNYTLGCVAQSEANTKEVLKFADKNTLIVLGEESRIKTFSVIN
>NC_016011.1|WP_014093922.1|2805895_2806831_-|LPXTG-cell-wall-anchor-domain-containing-protein
MKKFRGLVFTALFTCLIIPFSLAANAETNETGNNQPNIEEKTTNSTENTVPEVDSKTTEPAKDATTTKTLQTTIDITDSPEVYTYEQNSEISLTDFTKTLSKHTGTELTNYRLADGSELTTKAAGMKEVTLLGDTKDGDTTAVKLNYLVKAPVSTLTVTNLNFDLETKIFSGKTKPFASVYMSSPEDENFGEGRVEADKDGNFYASWATTPKKITAYAFDDTGNFSEEVTYTVPAKKENAAVVKAPADVKKIENNHSVKSVTTTASEASKKVADPESDLPDTGDQGVEWIFVVAGVIVILIAIVLLRKRKK

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_016011_2	2.2\|469926\|37\|NC_016011\|PILER-CR,CRISPRCasFinder,CRT	469926-469962	37	NZ_CP030151	Bacillus velezensis strain DSYZ plasmid pDSYZ, complete sequence	46249-46285	4	0.892
NC_016011_2	2.2\|469926\|37\|NC_016011\|PILER-CR,CRISPRCasFinder,CRT	469926-469962	37	NZ_CP026611	Bacillus velezensis strain CGMCC 11640 plasmid unnamed, complete sequence	22656-22692	4	0.892
NC_016011_1	1.1\|451390\|35\|NC_016011\|PILER-CR,CRISPRCasFinder,CRT	451390-451424	35	KY971610	Pseudomonas phage PspYZU05, complete genome	103571-103605	11	0.686

1. spacer 2.2|469926|37|NC_016011|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP030151 (Bacillus velezensis strain DSYZ plasmid pDSYZ, complete sequence) position: , mismatch: 4, identity: 0.892

agcttcctttttttaagaaattagcaacattttcagc	CRISPR spacer
tactgcctttatttaagaaattagcaacattttcagc	Protospacer
 .** ***** **************************

2. spacer 2.2|469926|37|NC_016011|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP026611 (Bacillus velezensis strain CGMCC 11640 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.892

agcttcctttttttaagaaattagcaacattttcagc	CRISPR spacer
tactgcctttatttaagaaattagcaacattttcagc	Protospacer
 .** ***** **************************

3. spacer 1.1|451390|35|NC_016011|PILER-CR,CRISPRCasFinder,CRT matches to KY971610 (Pseudomonas phage PspYZU05, complete genome) position: , mismatch: 11, identity: 0.686

ctgtataaatttcatccgatgaatttcgacatcgt	CRISPR spacer
atgtagaaatttcatcagatgaattttattctatg	Protospacer
 **** ********** *********.. . *

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

117610 : 120795

Listeria_phage(50.0%)

holin

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014091672.1\|117610_118063_-	ImmA/IrrE family metallo-endopeptidase	A0A059T7S0	Listeria_phage	4.7e-32	49.3
WP_014091673.1\|118068_118404_-	helix-turn-helix transcriptional regulator	A0A2H4JAR9	uncultured_Caudovirales_phage	3.1e-20	51.5
WP_014091674.1\|118627_119056_+	hypothetical protein	A8ATZ8	Listeria_phage	2.3e-12	45.9
WP_014091675.1\|119067_119487_+	hypothetical protein	A8ASQ1	Listeria_phage	5.5e-19	38.6
WP_014091676.1\|119663_120086_+\|holin	holin family protein	Q2I8E7	Bacillus_phage	5.6e-27	45.6
WP_077905816.1\|120117_120795_+	N-acetylmuramoyl-L-alanine amidase	A0A0N9SGH1	Paenibacillus_phage	1.2e-26	41.5

DBSCAN-SWA_2

1269300 : 1324838

Bacillus_virus(17.65%)

tRNA,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014092665.1\|1269300_1270440_-\|protease	PrsW family intramembrane metalloprotease	NA	NA	NA	NA
WP_014092666.1\|1270521_1270917_-	helix-turn-helix transcriptional regulator	A9D9J6	Lactobacillus_prophage	3.0e-14	55.9
WP_014092667.1\|1271067_1271283_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_025279905.1\|1271436_1271970_+\|protease	matrixin family metalloprotease	NA	NA	NA	NA
WP_014092669.1\|1271984_1272653_+	hypothetical protein	NA	NA	NA	NA
WP_014092670.1\|1273075_1274014_+	hypothetical protein	NA	NA	NA	NA
WP_014092671.1\|1274129_1275413_+	trigger factor	NA	NA	NA	NA
WP_003719537.1\|1275599_1276859_+\|protease	ATP-dependent protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	1.0e-145	63.2
WP_014092672.1\|1276976_1277543_+	type I signal peptidase SipX	NA	NA	NA	NA
WP_014092673.1\|1277577_1278147_+	type I signal peptidase SipY	NA	NA	NA	NA
WP_014092674.1\|1278249_1278792_+	type I signal peptidase SipZ	NA	NA	NA	NA
WP_025279906.1\|1278801_1279665_+	ribosome biogenesis GTPase YlqF	NA	NA	NA	NA
WP_014092675.1\|1279661_1280447_+	ribonuclease HII	G9E3X7	Emiliania_huxleyi_virus	3.8e-29	42.3
WP_014092676.1\|1280580_1281441_+	DNA-protecting protein DprA	NA	NA	NA	NA
WP_014092677.1\|1281710_1283789_+	type I DNA topoisomerase	A0A1V0SB35	Catovirus	6.0e-106	37.2
WP_014092678.1\|1283853_1285158_+\|tRNA	FADH(2)-oxidizing methylenetetrahydrofolate--tRNA-(uracil(54)-C(5))- methyltransferase TrmFO	NA	NA	NA	NA
WP_014092679.1\|1285443_1286346_+	tyrosine recombinase XerC	A0A2H4PCY2	Mycobacterium_phage	2.0e-13	28.1
WP_014092680.1\|1286366_1286906_+\|protease	ATP-dependent protease subunit HslV	NA	NA	NA	NA
WP_014092681.1\|1286919_1288329_+\|protease	ATP-dependent protease ATPase subunit HslU	A0A191ZC11	Erwinia_phage	4.9e-43	28.2
WP_014092682.1\|1288349_1289129_+	GTP-sensing pleiotropic transcriptional regulator CodY	NA	NA	NA	NA
WP_014092683.1\|1289227_1289647_+	acyl-CoA thioesterase	NA	NA	NA	NA
WP_014092684.1\|1289668_1289989_+	hypothetical protein	NA	NA	NA	NA
WP_014092685.1\|1289981_1290854_+	aldose 1-epimerase family protein	NA	NA	NA	NA
WP_025279907.1\|1290896_1291493_-	glycerol-3-phosphate 1-O-acyltransferase PlsY	NA	NA	NA	NA
WP_025279908.1\|1291650_1292058_+	CoA-binding protein	NA	NA	NA	NA
WP_014092686.1\|1292237_1294205_+	DNA topoisomerase IV subunit B	G3M9Z3	Bacillus_virus	9.6e-122	42.2
WP_014092687.1\|1294201_1296661_+	DNA topoisomerase IV subunit A	G3M9Z5	Bacillus_virus	1.5e-100	32.3
WP_014092688.1\|1296742_1297210_+	S-ribosylhomocysteine lyase	NA	NA	NA	NA
WP_014092689.1\|1297339_1299199_-	acetyltransferase	B5WZU0	Pseudomonas_phage	2.2e-43	31.9
WP_014092690.1\|1299408_1300116_+	glycerophosphodiester phosphodiesterase	A0A0S2MYI4	Enterococcus_phage	3.2e-11	38.7
WP_014092691.1\|1300337_1302014_+	glycerol-3-phosphate dehydrogenase/oxidase	NA	NA	NA	NA
WP_014092692.1\|1302139_1303057_+\|tRNA	tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA	NA	NA	NA	NA
WP_003719566.1\|1303171_1303405_+	RNA chaperone Hfq	NA	NA	NA	NA
WP_095075141.1\|1303511_1304756_+	GTPase HflX	NA	NA	NA	NA
WP_014092693.1\|1304727_1305954_+	methionine gamma-lyase family protein	NA	NA	NA	NA
WP_003719570.1\|1306156_1306525_+	MerR family transcriptional regulator	NA	NA	NA	NA
WP_014092694.1\|1306595_1307930_+	type I glutamate--ammonia ligase	A0A1V0SJ53	Klosneuvirus	3.5e-06	25.8
WP_014092695.1\|1308123_1309419_+	arsenic transporter	A0A2H4PQU3	Staphylococcus_phage	2.2e-146	62.6
WP_014092696.1\|1309457_1309979_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_014092697.1\|1310008_1310623_-	transcriptional repressor LexA	A0A1B2APZ1	Phage_Wrath	9.3e-15	62.1
WP_014092698.1\|1310777_1311107_+	cell division suppressor protein YneA	NA	NA	NA	NA
WP_014092699.1\|1311204_1311432_+	DUF896 domain-containing protein	NA	NA	NA	NA
WP_014092700.1\|1311578_1313573_+	transketolase	NA	NA	NA	NA
WP_003723442.1\|1313794_1314034_+	YneF family protein	NA	NA	NA	NA
WP_014092701.1\|1314092_1314896_-	DUF2785 domain-containing protein	NA	NA	NA	NA
WP_014092702.1\|1315662_1316169_-	ParB-like nuclease domain-containing protein	A0A220GKT8	Streptococcus_phage	2.1e-52	63.0
WP_014092703.1\|1316178_1317483_-	DUF3440 domain-containing protein	A0A220GKF8	Streptococcus_phage	3.2e-129	50.5
WP_014092704.1\|1317472_1318672_-	DEAD/DEAH box helicase	L0P6E9	Lactobacillus_phage	1.1e-88	46.1
WP_014092705.1\|1318655_1319030_-	hypothetical protein	NA	NA	NA	NA
WP_003723449.1\|1319331_1320060_+	UMP kinase	NA	NA	NA	NA
WP_014092706.1\|1320059_1320617_+	ribosome recycling factor	NA	NA	NA	NA
WP_014092707.1\|1320844_1321603_+	isoprenyl transferase	R9W0U9	Flavobacterium_phage	1.1e-22	42.6
WP_014092708.1\|1321616_1322405_+	phosphatidate cytidylyltransferase	NA	NA	NA	NA
WP_014092709.1\|1322419_1323562_+	1-deoxy-D-xylulose-5-phosphate reductoisomerase	NA	NA	NA	NA
WP_025279914.1\|1323575_1324838_+\|protease	RIP metalloprotease RseP	NA	NA	NA	NA

DBSCAN-SWA_3

1847615 : 1855926

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014093121.1\|1847615_1848209_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	5.4e-28	38.6
WP_014093122.1\|1848205_1849255_-	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	6.4e-64	44.4
WP_014093123.1\|1849270_1850698_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	3.1e-53	34.2
WP_014093124.1\|1850682_1852902_-	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	1.2e-157	41.1
WP_014093125.1\|1852894_1853578_-	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_014093126.1\|1853581_1853827_-	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_014093127.1\|1853838_1854552_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A1D8KNF0	Synechococcus_phage	2.0e-40	38.3
WP_014093128.1\|1854633_1855926_-	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	5.5e-17	32.6

DBSCAN-SWA_4

2013548 : 2021537

Faustovirus(14.29%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014093266.1\|2013548_2014634_-	histidinol-phosphate transaminase	A0A1X7BZP2	Faustovirus	5.5e-18	25.7
WP_014093267.1\|2014633_2015008_-	chorismate mutase	NA	NA	NA	NA
WP_014093268.1\|2015004_2016102_-	3-dehydroquinate synthase	E5ERI4	Ostreococcus_lucimarinus_virus	4.4e-23	29.3
WP_014093269.1\|2016104_2017271_-	chorismate synthase	A0A291AU41	Pandoravirus	5.4e-48	39.2
WP_014093270.1\|2017476_2017920_-	nucleoside-diphosphate kinase	D2E8E1	Anguillid_herpesvirus	6.9e-28	45.8
WP_014093271.1\|2017939_2018905_-	heptaprenyl diphosphate synthase component II	A0A1V0SE37	Indivirus	1.1e-06	20.9
WP_014093272.1\|2018915_2019629_-	demethylmenaquinone methyltransferase	NA	NA	NA	NA
WP_014093273.1\|2019651_2020419_-	heptaprenyl diphosphate synthase component 1	NA	NA	NA	NA
WP_014093274.1\|2020477_2021047_-	GTP cyclohydrolase I FolE	E7DN69	Pneumococcus_phage	1.2e-40	47.2
WP_003720260.1\|2021261_2021537_-	HU family DNA-binding protein	A7KV42	Bacillus_phage	2.0e-25	69.7

DBSCAN-SWA_5

2523714 : 2531573

Streptococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014093686.1\|2523714_2524686_-	DNA-binding protein WhiA	Q7AWZ3	Streptococcus_phage	1.2e-51	39.4
WP_014093687.1\|2524693_2525662_-	YvcK family protein	A1IMD5	Streptococcus_phage	9.7e-67	42.7
WP_014093688.1\|2525663_2526539_-	RNase adapter RapZ	A0A0R8VB27	Thermobifida_phage	4.1e-08	28.8
WP_014093689.1\|2526647_2528378_-	phospho-sugar mutase	A0A1X9I671	Streptococcus_phage	2.0e-171	52.6
WP_014093690.1\|2528423_2529494_-	galactose mutarotase	NA	NA	NA	NA
WP_014093691.1\|2529512_2530496_-	UDP-glucose 4-epimerase GalE	A0A2K9L1R4	Tupanvirus	2.0e-51	37.2
WP_014093692.1\|2530613_2531573_-	thioredoxin-disulfide reductase	G3MA85	Bacillus_virus	7.5e-88	54.1

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_016011

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection