CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_016748	Marinitoga piezophila KA3 plasmid pMARPI01, complete sequence	0 crisprs	NA	0	0	0	0
NC_016751	Marinitoga piezophila KA3, complete sequence	5 crisprs	cas3,cas6,cas8b2,cas7,cas5,cas4,cas1,cas2,PrimPol,csx1,csm6,cmr6gr7,cmr5gr11,cmr4gr7,cmr3gr5,cas10,cmr1gr7,DEDDh,csa3	0	2	3	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_016751_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016751_1

289919-290816

Unclear

Consensus_repeat	Method
CTTTCTACAGTACCTATAAGGAATTGAAAT	PILER-CR
CTTTCTACAGTACCTATAAGGAATTGAAAT	CRISPRCasFinder
CTTTCTACAGTACCTATAAGGAATTGAAAT	CRT

13 spacers

cas2,cas1,cas4,cas3,cas5,cas7,cas8b2,cas6

The CRISPR arrays of NC_016751_1

>merge|NC_016751|1|289919-290816|PILER-CR,CRISPRCasFinder,CRT
CTTTCTACAGTACCTATAAGGAATTGAAATCTTAATAATTCAACAATTACGTCGTCTTTCTTCTATGCTTTCTACAGTACCTATAAGGAATTGAAATCGATGCTATAATTGAAGTTGTTTGTTCGTTTTCTCCGCTTTCTACAGTACCTATAAGGAATTGAAATCAGTCTCATGATAGCGTTACTTATGGTGGAATTAACTTTCTACAGTACCTATAAGGAATTGAAATGATGGATAGGAAAAGATAAAATATATAACTTCTTACCTTTCTACAGTACCTATAAGGAATTGAAATTCTGTTAATCTAAATTGATATGCTTTTTTAAATTCTTCTTTCTACAGTACCTATAAGGAATTGAAATAATTTTTTAAGAACTTTTTTATTGGTATCTAATGCATGCTTTCTACAGTACCTATAAGGAATTGAAATAATATTTCAACAGCTTCAAACATGAGCTTTTTAAATAACTTTCTACAGTACCTATAAGGAATTGAAATCGGTTATACAGTTGTTAGTGAGGGAGTGGAATTGATGCTTTCTACAGTACCTATAAGGAATTGAAATATACCAATTAAGGAGGTTGTTTAATCATGTTATTTGACTTTCTACAGTACCTATAAGGAATTGAAATCCTCACTTCAAAATAATTTTATGATTTTCAATTTTTCCCACTTTCTACAGTACCTATAAGGAATTGAAATAAAATCCAGCTGTTTTGGATGAAATAGAGGAAACACTTTCTACAGTACCTATAAGGAATTGAAATCAAGATGATGATTTAATGAATCAAGTTCCAACAATACTTTCTACAGTACCTATAAGGAATTGAAATAGAAATTGAAAATTTAAACTTAGAAGCAAATTTAACTTTCTACAGTACCTATGCACTTACCCCAA

>NC_016751|1|1|289919-290751|PILER-CR
CTTTCTACAGTACCTATAAGGAATTGAAAT	CTTAATAATTCAACAATTACGTCGTCTTTCTTCTATG
CTTTCTACAGTACCTATAAGGAATTGAAAT	CGATGCTATAATTGAAGTTGTTTGTTCGTTTTCTCCG
CTTTCTACAGTACCTATAAGGAATTGAAAT	CAGTCTCATGATAGCGTTACTTATGGTGGAATTAA
CTTTCTACAGTACCTATAAGGAATTGAAAT	GATGGATAGGAAAAGATAAAATATATAACTTCTTAC
CTTTCTACAGTACCTATAAGGAATTGAAAT	TCTGTTAATCTAAATTGATATGCTTTTTTAAATTCTT
CTTTCTACAGTACCTATAAGGAATTGAAAT	AATTTTTTAAGAACTTTTTTATTGGTATCTAATGCATG
CTTTCTACAGTACCTATAAGGAATTGAAAT	AATATTTCAACAGCTTCAAACATGAGCTTTTTAAATAA
CTTTCTACAGTACCTATAAGGAATTGAAAT	CGGTTATACAGTTGTTAGTGAGGGAGTGGAATTGATG
CTTTCTACAGTACCTATAAGGAATTGAAAT	ATACCAATTAAGGAGGTTGTTTAATCATGTTATTTGA
CTTTCTACAGTACCTATAAGGAATTGAAAT	CCTCACTTCAAAATAATTTTATGATTTTCAATTTTTCCCA
CTTTCTACAGTACCTATAAGGAATTGAAAT	AAAATCCAGCTGTTTTGGATGAAATAGAGGAAACA
CTTTCTACAGTACCTATAAGGAATTGAAAT	CAAGATGATGATTTAATGAATCAAGTTCCAACAATA
CTTTCTACAGTACCTATAAGGAATTGAAAT

>NC_016751|1|1|289919-290751|CRISPRCasFinder
CTTTCTACAGTACCTATAAGGAATTGAAAT	CTTAATAATTCAACAATTACGTCGTCTTTCTTCTATG
CTTTCTACAGTACCTATAAGGAATTGAAAT	CGATGCTATAATTGAAGTTGTTTGTTCGTTTTCTCCG
CTTTCTACAGTACCTATAAGGAATTGAAAT	CAGTCTCATGATAGCGTTACTTATGGTGGAATTAA
CTTTCTACAGTACCTATAAGGAATTGAAAT	GATGGATAGGAAAAGATAAAATATATAACTTCTTAC
CTTTCTACAGTACCTATAAGGAATTGAAAT	TCTGTTAATCTAAATTGATATGCTTTTTTAAATTCTT
CTTTCTACAGTACCTATAAGGAATTGAAAT	AATTTTTTAAGAACTTTTTTATTGGTATCTAATGCATG
CTTTCTACAGTACCTATAAGGAATTGAAAT	AATATTTCAACAGCTTCAAACATGAGCTTTTTAAATAA
CTTTCTACAGTACCTATAAGGAATTGAAAT	CGGTTATACAGTTGTTAGTGAGGGAGTGGAATTGATG
CTTTCTACAGTACCTATAAGGAATTGAAAT	ATACCAATTAAGGAGGTTGTTTAATCATGTTATTTGA
CTTTCTACAGTACCTATAAGGAATTGAAAT	CCTCACTTCAAAATAATTTTATGATTTTCAATTTTTCCCA
CTTTCTACAGTACCTATAAGGAATTGAAAT	AAAATCCAGCTGTTTTGGATGAAATAGAGGAAACA
CTTTCTACAGTACCTATAAGGAATTGAAAT	CAAGATGATGATTTAATGAATCAAGTTCCAACAATA
CTTTCTACAGTACCTATAAGGAATTGAAAT

>NC_016751|1|1|289919-290816|CRT
CTTTCTACAGTACCTATAAGGAATTGAAAT	CTTAATAATTCAACAATTACGTCGTCTTTCTTCTATG
CTTTCTACAGTACCTATAAGGAATTGAAAT	CGATGCTATAATTGAAGTTGTTTGTTCGTTTTCTCCG
CTTTCTACAGTACCTATAAGGAATTGAAAT	CAGTCTCATGATAGCGTTACTTATGGTGGAATTAA
CTTTCTACAGTACCTATAAGGAATTGAAAT	GATGGATAGGAAAAGATAAAATATATAACTTCTTAC
CTTTCTACAGTACCTATAAGGAATTGAAAT	TCTGTTAATCTAAATTGATATGCTTTTTTAAATTCTT
CTTTCTACAGTACCTATAAGGAATTGAAAT	AATTTTTTAAGAACTTTTTTATTGGTATCTAATGCATG
CTTTCTACAGTACCTATAAGGAATTGAAAT	AATATTTCAACAGCTTCAAACATGAGCTTTTTAAATAA
CTTTCTACAGTACCTATAAGGAATTGAAAT	CGGTTATACAGTTGTTAGTGAGGGAGTGGAATTGATG
CTTTCTACAGTACCTATAAGGAATTGAAAT	ATACCAATTAAGGAGGTTGTTTAATCATGTTATTTGA
CTTTCTACAGTACCTATAAGGAATTGAAAT	CCTCACTTCAAAATAATTTTATGATTTTCAATTTTTCCCA
CTTTCTACAGTACCTATAAGGAATTGAAAT	AAAATCCAGCTGTTTTGGATGAAATAGAGGAAACA
CTTTCTACAGTACCTATAAGGAATTGAAAT	CAAGATGATGATTTAATGAATCAAGTTCCAACAATA
CTTTCTACAGTACCTATAAGGAATTGAAAT	AGAAATTGAAAATTTAAACTTAGAAGCAAATTTAA
CTTTCTACAGTACCTATGCACTTACCCCAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_016751.1\|WP_014295802.1\|288499_289495_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|187853
NC_016751.1\|WP_014295794.1\|279259_280504_+\|hypothetical-protein	unknown	unknown	unknown
NC_016751.1\|WP_148265181.1\|288009_288495_+\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
NC_016751.1\|WP_014295813.1\|301083_301893_+\|hypothetical-protein	unknown	unknown	unknown
NC_016751.1\|WP_041638715.1\|281552_282308_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	gnl\|CDD\|187783
NC_016751.1\|WP_014295807.1\|294693_295224_-\|hypothetical-protein	unknown	unknown	unknown
NC_016751.1\|WP_014295795.1\|280546_281137_+\|hypothetical-protein	unknown	unknown	unknown
NC_016751.1\|WP_014295815.1\|303450_303612_-\|hypothetical-protein	unknown	unknown	unknown
NC_016751.1\|WP_014295816.1\|303768_304140_-\|STAS-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|379507
NC_016751.1\|WP_171814207.1\|294444_294618_+\|hypothetical-protein	unknown	unknown	unknown
NC_016751.1\|WP_014295803.1\|289497_289758_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NC_016751.1\|WP_014295814.1\|301978_303448_-\|recombinase-family-protein	unknown	unknown	gnl\|CDD\|214861
NC_016751.1\|WP_014295797.1\|282403_283783_+\|CRISPR-associated-protein-(Cas_CXXC_CXXC)	cas8b2	cls000029_cas8b2_CAS-I-B	gnl\|CDD\|187796
NC_016751.1\|WP_014295817.1\|304156_305122_-\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132913
NC_016751.1\|WP_014295810.1\|295872_297603_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_016751.1\|WP_014295812.1\|299456_300731_-\|TrpB-like-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|237087
NC_016751.1\|WP_014295811.1\|297603_299358_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_016751.1\|WP_014295800.1\|285557_287909_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|187770
NC_016751.1\|WP_014295799.1\|284850_285507_+\|type-I-B-CRISPR-associated-protein-Cas5	cas5	COG1688_cas5_CAS-I	gnl\|CDD\|273860
NC_016751.1\|WP_014295798.1\|283795_284848_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818

Protein	Function_ID	Function_description	E-value
NC_016751.1\|WP_014295802.1\|288499_289495_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187853	cd09722, Cas1_I-B, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	1.73644e-148
NC_016751.1\|WP_041638715.1\|281552_282308_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|187783	cd09652, Cas6-I-III, CRISPR/Cas system-associated RAMP superfamily protein Cas6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas6 is an endoribonuclease that generates crRNAs, predicted subunit of Cascade complex; RAMP superfamily protein; Possesses double RRM/ferredoxin fold.	7.14597e-27
NC_016751.1\|WP_148265181.1\|288009_288495_+\|CRISPR-associated-protein-Cas4	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	8.63344e-56
NC_016751.1\|WP_014295817.1\|304156_305122_-\|STAS-domain-containing-protein	gnl\|CDD\|132913	cd07042, STAS_SulP_like_sulfate_transporter, Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function. The SulP family is a large and diverse family of anion transporters, with members from eubacteria, plants, fungi, and mammals. They contain 10 to 14 transmembrane helices which form the catalytic core of the protein and a C-terminal extension, the STAS (Sulphate Transporter and AntiSigma factor antagonist) domain which plays a role in the function and regulation of the transport activity. The STAS domain is found in the C-terminal region of sulphate transporters and bacterial anti-sigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.	0.000527382
NC_016751.1\|WP_014295799.1\|284850_285507_+\|type-I-B-CRISPR-associated-protein-Cas5	gnl\|CDD\|273860	TIGR01895, conserved_hypothetical_protein, CRISPR-associated protein Cas5, subtype I-B/TNEAP. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This family is represented by TM1800 from Thermotoga maritima. It is related to TIGR01868 (CRISPR-associated protein, CT1976 family).	1.38315e-35
NC_016751.1\|WP_014295816.1\|303768_304140_-\|STAS-like-domain-containing-protein	gnl\|CDD\|379507	pfam14213, DUF4325, STAS-like domain of unknown function (DUF4325). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria, archaea, eukaryotes and viruses. Proteins in this family are typically between 99 and 341 amino acids in length. This domain is distantly related to the STAS domain.	3.6067e-09
NC_016751.1\|WP_014295812.1\|299456_300731_-\|TrpB-like-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|237087	PRK12391, PRK12391, TrpB-like pyridoxal phosphate-dependent enzyme.	0
NC_016751.1\|WP_014295803.1\|289497_289758_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	2.31181e-27
NC_016751.1\|WP_014295814.1\|301978_303448_-\|recombinase-family-protein	gnl\|CDD\|214861	smart00857, Resolvase, Resolvase, N terminal domain. The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.	5.1361e-30
NC_016751.1\|WP_014295797.1\|282403_283783_+\|CRISPR-associated-protein-(Cas_CXXC_CXXC)	gnl\|CDD\|187796	cd09665, Cas8a1_I-A, CRISPR/Cas system-associated protein Cas8a1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Large proteins, some contain Zn-finger domain; signature gene for I-A subtype; also known as CXXC_CXXC family.	7.63538e-17
NC_016751.1\|WP_014295810.1\|295872_297603_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	4.22341e-176
NC_016751.1\|WP_014295811.1\|297603_299358_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	4.87323e-180
NC_016751.1\|WP_014295800.1\|285557_287909_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	2.46814e-63
NC_016751.1\|WP_014295798.1\|283795_284848_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	2.0042e-56

>NC_016751.1|WP_014295803.1|289497_289758_+|CRISPR-associated-endonuclease-Cas2
MFVILYYDANEKRVSKFLKVCRKYLTWVQNSVFEGEITKANLEKLKYELKTKVKDNDSIIIYEFRSMNYSKREVIGIDKKENNKFI
>NC_016751.1|WP_014295802.1|288499_289495_+|type-I-B-CRISPR-associated-endonuclease-Cas1
MKETIYIFSSGELKRKDNSIVFITSDNKKRYIPIENLKEILIFGEVNITKKTLEFLSQKEIIVSFYNYYGYYMGSYYPREHYNSGYMILKQAEHYINEIKRSKLAKSFVIGATKNSLKILKYYNRREKNLEEYIKKIESLLMKLEKKSKIKEIMTIEAEIKKEYYKTFKIIIENEAFEFSKRSKRPPEDRINALISFSNSIIYNMILKEIYTTHLDPRIGYLHTTNFRRFTLNLDIAEIFKPVIGDRTIFNVINKKIINEKHFETGISGVFLNNKGKQKFLEKLEERLKQTIKHYKLNKRVSYRYLIKIELYKLEKHLIGEEEYKPFVMEW
>NC_016751.1|WP_148265181.1|288009_288495_+|CRISPR-associated-protein-Cas4
MYGSLIQSYFICKRQTWLLAHQLIGEQDNMFIEIGRFIAEKSYQNTKKEIKIDGGIIDFIKKENGKTIVAEVKKSSKNIKSAEYQLLFYLKKLKGKIDIQYAEIRIPVEKKIIKIELTEEKEKELEKIEEEIITIINKELPPMPEKIKYCKTCSYQNFCWG
>NC_016751.1|WP_014295800.1|285557_287909_+|CRISPR-associated-helicase/endonuclease-Cas3
MKSVKSNENLILAKSDGTTLLEHIEDNIVILNNLKRMLPLLPKITKLDNFWDILFSTIFFHDFGKIHKEFQKYIKGEKNLWTKQRHEIYSIPFIDKLNLDERYIKLIKKVILSHHKSFYELKYNYLKSKEDLEYEYELNWKNKTKFHPQDYEGNLKYNFDKKVIDFYIKKFDELAKKYHISVQLKNEKIKINNIRNPIEEFAYNLEKYNKEEYLQHLLLWGSLKICDHLGSAKIIEIYMFEEKHFVFLDEMKRKIEFYDHQKKCFSIKGSCLLIAPTGSGKTESAIGWVKTQLENKQGRVFYVLPYTASINAMHKRLIKNMDRSASKISNIIGILHGNISHYISIYFEEGITKNENSIRNKKIKKIIKQYKNLLSPLIVCTPFQLLKYFYGVKGFEKGFVFFSGAKLIFDEIHAYDIVTFAQIVVMLEVLKKDFLCDVMIMTATIPTFMQNILAERLNIDNIITADKKFVEKLKRHKIKIVDKNIFDFIDSNFRKIINNHNKIILVCNTVEQSQKVYMKVRDMNICSDNEIVLIHGRFNQHDRNDKEKAIYNQKTKILIGTQTIEVSLDIDYDVMITEPAPIDALLQRFGRVNRNSKKKPAPVYICRKGGEYDHYIYPINKIEKTLEVLNDVDILCEKNIGNLIDEVYPNWNDFEKKEFEDTVSLFRNSLKSLQPFSDTKETEEFYYSKFTNIKVLPACYYSKYINLMELYNFIEAEKLLVNINRNFFYKYIKEGKIEKRELVLSEDEKILKKHSFYIIKCKYNSEVGLINEYEEIKHDINFI
>NC_016751.1|WP_014295799.1|284850_285507_+|type-I-B-CRISPR-associated-protein-Cas5
MKVYRIYISSWTASFRYPNLISGFQPTLLVPPFSTINGLISSAKGDYFIPQKEKIGYVFRAKSKNIDLETIYQMEKSLKNIKSNVIKREFLVEAELFLYTDSKVIAGYFLKPKYQLLLGRSSDLATVKNIDEIEIEEKNNLKNLKGTIIPLKYGIMPGVIHALPKYFSNTIPRKNIGTQPYCILDWNYKQEEITIHALGFSDYDKKLKIDWDVYWQEP
>NC_016751.1|WP_014295798.1|283795_284848_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MNTIQGFMLIDVDVAALNNAGNDTSTTLDNAVMTKKIRKDGKEYPYVSGQAWRYWWRETLMRNFNWQISPIIREKKIAYTEADPLKYADDDIFGYMRAGKKNIIDTKTGKSKSINVTLTRVSPLKNSALIAVSYNPIVQHWSSMSRHEGDAVPYGKDEYCAIMKGMFSIDLDMVGTFSSMNKTGFQNINEDMRQLYLEKEGVFEIDDPFAKDINGNPLKLIRLPKEIREQRVKDVILALKYLSGGAKQTTNFADVTPKIIVLAILKSGNHPFSHLAKEEMGKAVFSVDALKEVINDYQDKFDNKIFVGKRKGFMDEIESDLIKLKEENLIEYGSVNKIIDKFVKTIDLGE
>NC_016751.1|WP_014295797.1|282403_283783_+|CRISPR-associated-protein-(Cas_CXXC_CXXC)
MVTGDPFVDAGGVVLEYLKNQFPEKNIIDLIDFAAEIFIYKWNGKIDSLQLNSNITHNSKRGSLEKQKKAKENVKKYFENILNSGSFSDASGYCRICGKKGKNFKVGRETFPLSGSGKFVNFHHGHENGILLCNDCITKLFFLPLAVLQMRKNLALLHVHSEKIKEYWIEKVIKKNLDNYSKNISEGILKSKLNNPKNALFEMASELINEFEAKNEYLQLFYFTNFGANPNCEIYILPNPVFRFISKVLRYCRKDWFVFIKRYYKVSKATWDYTTFEWVSEKEGKITKDYYQDEKNMVIEYLLEGKSLIGILKKFYRENFLKKKEVSSLILDYYLKEVKNMDLKQIELIKRLGKSIIEISRKENNFKKYLTMIEGANKAFQLRAIIITLIKKHYINGEEKPLITLDEYVNYLFPDGQYWSEIRDILLIYLYELLHEENIKNIDVEESNLEEPEDELIEF
>NC_016751.1|WP_041638715.1|281552_282308_+|CRISPR-associated-endoribonuclease-Cas6
MRIKVEFISDNNIILPIGFNKYIQALIYNMFSQKLRKFIHENGFESFSKRVYRFFTFSSILERGKYYKKMKIFNFGNKISFYISSPINEILEDILNNLFEKDRFSLGENILYLSSVISLGSFYTEKNIINIKMLTPLEVHKTEIINNKKKTIYYSPFSAEFEELINLNLKHKWEAFYNKELKESIKIIPLFNENKYKKIVYYGLGDKKYIIEGWMGNYKMKGDPKIIKFLYDVGLGSKNSQGFGMFEVLRE
>NC_016751.1|WP_014295795.1|280546_281137_+|hypothetical-protein
MHLKKERYFLGIGIILMFINELNTIGIILQFIGIYLLSEKTNNKKTFYYFVISLFLFYSLISFFVPQSIIMIFKNYPGLANNFDSLFTLRYSLLESIRNYFFVISLSFFIYLISLILERIAYKNLYDITLSKELSIAIKLISVEAVVLTFSYLLLAKFVIDDVIILNLLIILFVLNLTLIFLIKLFEIIGFINIEQ
>NC_016751.1|WP_014295794.1|279259_280504_+|hypothetical-protein
MGYYSKSPEEWKKLDEEKAKKDKLRQIQKRRQKINNMLIIFISILAIAFIFISKKYFPRYNFGFYVLVDKISYSIFSSDKYTYPDPLTISVSMNNSTTSPIDVKIDSFKFIIYKITGDSSETFYKFEYPKIIKYQLSPYETKKIFDLMNINPLSKIPDGKYIIYSTFNSNGKEIKLHKEIDYIHTVRYNVYLKKGFFLENEYPQLIIEARNYSEETRQFEFKGTIQIYTKKKKLIKEIPVDFGYLTLKSLEKKVNDFNIPRIEKGTYDLYFVSKQFNQAVYIPFPITDKIETKLKNISLSMDTYLFYPVNEKFQGIFYINNKDLKKERFIEITGYSLRLINLDKNTVVFNYENSDKRRIYINAGGKAIVYYLSPYDRPVTLSIPGKYQLIYTVKTNESVIERKVTVYVGINQNK
>NC_016751.1|WP_171814207.1|294444_294618_+|hypothetical-protein
MIKIKKIKLYDYEEYKENAFRKNPRLKEAYDSLEEKYKAISQEIINNMNLVKKDKDI
>NC_016751.1|WP_014295807.1|294693_295224_-|hypothetical-protein
MKKLLTALLVGGLMTGSIFAFNANAPRVYQETSGTVPMYQNYQGVPGGYLFTEENMLTVTGVIESIEENEDYPGLLEIKVKTEAGEEIELHANAYFAGSLEIGQTMEVTGWSVEINGEKIFRPAETKIDGEEVLLNGFRGSARGTGYASQTQYPAQPGAYAKPAPRGRGHGGRGRF
>NC_016751.1|WP_014295810.1|295872_297603_+|ABC-transporter-ATP-binding-protein
MKSILKYVSQQKRFIIIASLCLIGGVSAELILPYLNKIVIDDIIVGGKRNLLFPVLSGIFFITIFRALMGYSQEFLFDFTGSQISKNIKNDLFKHIQKLPFTYFDKTNTGELMSRIGEDVDNIWNALGFGISIAVEFALYFILGSLVLFYLNWKLALISLISAPAIAYLATKLENEIGKAFDKISDQAAVINTTAQENISGVRLVKAFAREKYEIMKFLKLNNENYELNLEKSRIWGKYFPTIEFLGNGALILVVTVGGALVIKGNISIGTLVAFNGYMWMIVWPMRLIGWLSNIFSQANASAKKIEKILKEDTEDFKGIKIEKLNGEIEFKNVSFKYDNEYVLKNINFKIKPGKTLAIMGPTGCGKSTLISLLSRFYEIDEGEILIDGINIKDFSLNTLRKNISYVFQDTFLFSDTVKENIKYGKDNIDDKEIISACKEAQAYDFIMKLPEKFDTIIGERGLGLSGGQKQRLTIARALIKKAPIIIFDDATSALDMDTEYELLKSIYSKELQNTKIIIAHRISAVKNADEIIYLDNGEIIERGTHDELLNMKGRYYEIYAEQFKDFEDLIEDEVV
>NC_016751.1|WP_014295811.1|297603_299358_+|ABC-transporter-ATP-binding-protein
MNLKFEKTKTILRIFSYLKPFFKQTIMVIFLMIIVMGINLINPYFFKIAIDKYIANNNLNGLIIVGVAVMFLNLLSLFISRMRIILMGKITNKIVVNIRHELYEHIQKLSFSFFDTKPVGKILARVVNDVNSLQQLFSNSITSLVPEFLTLVFVAIIMFSMNFKLALASMIILPFLLFGLFLIENISRKRWMNYRKNRSELNAFTHEDISGIRIIKSFTAENKTNKKFRFLTQKMMNSFVNAVKINDWFWAMVLVSWGIGSVVVFYLSTKMIDLNEITVGTVVAFIGYIGMFWRPIMNLSNFYNSLVTNISAAERIFEILDTKPLIVNSKNARIMPEIKGKVEFKNVYFSYDKEIILKDMSFKVNAGETIALVGPTGAGKTTVINLISRFYDPQKGKILIDGIDIKNVDLESLRSQMGIMLQDTFLFSDTIKENIRYGKLDATDEEIINVAKAVHAHEFIMKLEKGYDTKVNERGVRLSIGERQLISFARALLANPKILILDEATSNIDTHTEKLVQDGIKKLLKGRTSFVIAHRLSTIRNADRIFYIDNGKIIESGNHDELMSKKGFYYNLYLSQFKFLEIGA
>NC_016751.1|WP_014295812.1|299456_300731_-|TrpB-like-pyridoxal-phosphate-dependent-enzyme
MGKRERVYLSVEEMPKYWYNALADLPFELDPPLNPQTKEIMKPEELEAIFPKPIVEQEVTKERYIKIPDAVLEEYAIFRPTPLIRATNLEEYLETPARIYYKYEGVSPTGSHKTNTSIPQAYYNKISGVDTLVTETGAGQWGSALSYAGLKFGLNIEVYMVKTSFEQKPMRKHLINLFNGKVTPSPSLDTEFGKKMISMDEDNPGSLGIAISEALEVVFTKKNAKYALGSVLNHVLLHQSIIGLEIKKQLEKINESADVVIGCHGGGSNLGGTILPFVPEKLSNDNIKFLACEPKSCPSLTEGEYRYDNGDTAGLTPLMKMYTLGKEFIPPKIHAGGLRYHGSAPIIARLKHEGLLDAVAFSQDETFEAAKLFAKLEGIVPAPESSHAIAGAIKEAIEAKENKEEKVIVFTLSGHGLLDLTAYS
>NC_016751.1|WP_014295813.1|301083_301893_+|hypothetical-protein
MKINTEIIDTYLMEKNLKKISNNKIFSLIENGKILFEAPPEESYQKIKNTYNLFKNIIFSFKPCNYNIWKNIFEISDNTDNSFIIFPIIGAPSPYEAMIRYDENGNTLMIFDIYLLGKNIDNLPKLKENISLLITHELAHYYIHQRFQYPQKIENQLKYLFFDEGFAHFLSYSNNIEQINWNEKKYIKKREYSYEMLKEKLKNKLDKNLLIKGITANNYWDKYIAISGMFAIIDFWHSNNKKLDSLKLLYKKGPEYLWNFWEINYLTKT
>NC_016751.1|WP_014295814.1|301978_303448_-|recombinase-family-protein
MKKAAAYARVSTKDQSKISIEGQFKTIENFAKQYGFKIVDYFSDKDSGKKMKREQLDILLENAYKGKYDVILVEKYDRFSRAGIDGQVIIQDLEKNYNVLVIAALEPFDVSTPQGRFTRTIILASYTLEGEMISQRTKMRMKDIASKKYWMGGNPPFGFDSYQIIDDEGKKRRKLKINEEQAKIVREIFELRLKNIGYSEIAKRLNERGIKNARGNLWRGSTILDMINNPLYAGIYIYGKGNKRSRKRSSELKDAVIIENFVEPIISREVFEEVNRKNGKLTNALTRHKYLLKGLIYTENGDRMVGAGGKTPSYVSSAWHSGKTRGYIGIAKSKIEREVFLHVKHRLLEFDFDDDEFWEEFAETLNYVKKLKMNIENEKVLALRKRLEEIEEQLINITNAIKAGIINDEIKKENELLTKEKNDIINQIKMADMHFDTETPERLKKKWREKIQALENYDEDKLIEIYNQLIERIIVYKDKFIEINFKQIE
>NC_016751.1|WP_014295815.1|303450_303612_-|hypothetical-protein
MIIVRVLVSEEDLDLLKEFGFMFWDERKLNQDELYAFYKFLLLLQKVSKEGSE
>NC_016751.1|WP_014295816.1|303768_304140_-|STAS-like-domain-containing-protein
MLIKLFEMYNTDILGTRYEGEKLRIILKKYLENTKDIIYIDFNNINVVTHSFLDQAVGTLFSEYGPIVFKRIKFKNAQNSVKSIGKLIKIDRVRDFIFKPDKYAYKKVPLHILNHFKSNYHRI
>NC_016751.1|WP_014295817.1|304156_305122_-|STAS-domain-containing-protein
MEVIELPNKVTLDNVLTLINLTQQSFNNGNEILFDFSKVSFVDPFGANFLVLLIKNLENKGIKINVNILELNSDVFDYLNRMNFFDKLGIDYLEYPHVKHDSNNRFLEMKEIYSIEEIPDVEKHFQKVIKDEDLARFLGYQIRELLDNIFSHAESSIGALLMSQKYHSSSTEKIIFSVGDLGVGIPATLKPFFQNISMDHLLIEKSLDFGVSSKKNSGIYFGSDHRGAGLYYIKRYVQMNKWNLLVISKKGLYFIKRGKETIKKEFKYNIIDGTLFALSINNENIFDYDILHEMLLNETSEYLNKNVNSDIILDEDFDEEW

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Crispr_ID: NC_016751_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016751_2

293786-294417

Unclear

Consensus_repeat	Method
TTTCTACAGTACCTATAAGGAATTGAAA	CRT
CTTTCTACAGTACCTATAAGGAATTGAAAT	CRISPRCasFinder
GTACCTATAAGGAATTGAAA	PILER-CR

9 spacers

cas2,cas1,cas4,cas3,cas5,cas7,cas8b2,cas6

The CRISPR arrays of NC_016751_2

>merge|NC_016751|2|293786-294417|CRT,CRISPRCasFinder,PILER-CR
TGGTCAAATCCACTATAAGGAATTGAAATAAATCTTTGTTAAGCTGTTCGGCAATATCTAAATTTCTTTCTACAGTACCTATAAGGAATTGAAATAAGACTAACCAATAATAAGCTGGTAAATGTAAAGCTCTTTCTACAGTACCTATAAGGAATTGAAATCTGTCTGTAATTTTACCAAAACTTTCTGATGTATTATCCTTTCTACAGTACCTATAAGGAATTGAAATTAAATTCTTGTTATATTAAATAATCCCTGTTTATATCTTTCTACAGTACCTATAAGGAATTGAAATACAACAATAAATCCTTTTAAGCCTGAAGGCACTCTTTTAACTTTCTACAGTACCTATAAGGAATTGAAATTAAAAATAAAAATTAAATTCTTTTGCATTTAACATACTTTCTACAGTACCTATAAGGAATTGAAATTTAAAAAAATTATCTCGTGAAAACGGAATGTATACACTTTCTACAGTACCTATAAGGAATTGAAACTTCACTGTCTGTCTCGTTACTCCAACTTTTTCCGCGGTTTTTATCGTAACTATAAGGAATTGAAAACTAAAAATATTTTGCAACCAGGAAGTTAAATCAACAACTGTTTTTATCGTAACTATAAGGAATTGAAAA

>NC_016751|2|2|293786-294416|CRT
TGGTCAAATCCACTATAAGGAATTGAAA	TAAATCTTTGTTAAGCTGTTCGGCAATATCTAAATTTC
TTTCTACAGTACCTATAAGGAATTGAAA	TAAGACTAACCAATAATAAGCTGGTAAATGTAAAGCTC
TTTCTACAGTACCTATAAGGAATTGAAA	TCTGTCTGTAATTTTACCAAAACTTTCTGATGTATTATCC
TTTCTACAGTACCTATAAGGAATTGAAA	TTAAATTCTTGTTATATTAAATAATCCCTGTTTATATC
TTTCTACAGTACCTATAAGGAATTGAAA	TACAACAATAAATCCTTTTAAGCCTGAAGGCACTCTTTTAAC
TTTCTACAGTACCTATAAGGAATTGAAA	TTAAAAATAAAAATTAAATTCTTTTGCATTTAACATAC
TTTCTACAGTACCTATAAGGAATTGAAA	TTTAAAAAAATTATCTCGTGAAAACGGAATGTATACAC
TTTCTACAGTACCTATAAGGAATTGAAA	CTTCACTGTCTGTCTCGTTACTCCAACTTTTTCCGCGG
TTTTTATCGTAACTATAAGGAATTGAAA	ACTAAAAATATTTTGCAACCAGGAAGTTAAATCAACAACTG
TTTTTATCGTAACTATAAGGAATTGAAA

>NC_016751|2|2|293851-294417|CRISPRCasFinder
CTTTCTACAGTACCTATAAGGAATTGAAAT	AAGACTAACCAATAATAAGCTGGTAAATGTAAAGCT
CTTTCTACAGTACCTATAAGGAATTGAAAT	CTGTCTGTAATTTTACCAAAACTTTCTGATGTATTATC
CTTTCTACAGTACCTATAAGGAATTGAAAT	TAAATTCTTGTTATATTAAATAATCCCTGTTTATAT
CTTTCTACAGTACCTATAAGGAATTGAAAT	ACAACAATAAATCCTTTTAAGCCTGAAGGCACTCTTTTAA
CTTTCTACAGTACCTATAAGGAATTGAAAT	TAAAAATAAAAATTAAATTCTTTTGCATTTAACATA
CTTTCTACAGTACCTATAAGGAATTGAAAT	TTAAAAAAATTATCTCGTGAAAACGGAATGTATACA
CTTTCTACAGTACCTATAAGGAATTGAAAC	TTCACTGTCTGTCTCGTTACTCCAACTTTTTCCGCG
GTTTTTATCGTAACTATAAGGAATTGAAAA	CTAAAAATATTTTGCAACCAGGAAGTTAAATCAACAACT
GTTTTTATCGTAACTATAAGGAATTGAAAA

>NC_016751|2|2|293860-294416|PILER-CR
GTACCTATAAGGAATTGAAA	TAAGACTAACCAATAATAAGCTGGTAAATGTAAAGCTCTTTCTACA
GTACCTATAAGGAATTGAAA	TCTGTCTGTAATTTTACCAAAACTTTCTGATGTATTATCCTTTCTACA
GTACCTATAAGGAATTGAAA	TTAAATTCTTGTTATATTAAATAATCCCTGTTTATATCTTTCTACA
GTACCTATAAGGAATTGAAA	TACAACAATAAATCCTTTTAAGCCTGAAGGCACTCTTTTAACTTTCTACA
GTACCTATAAGGAATTGAAA	TTAAAAATAAAAATTAAATTCTTTTGCATTTAACATACTTTCTACA
GTACCTATAAGGAATTGAAA	TTTAAAAAAATTATCTCGTGAAAACGGAATGTATACACTTTCTACA
GTACCTATAAGGAATTGAAA	CTTCACTGTCTGTCTCGTTACTCCAACTTTTTCCGCGGTTTTTATC
GTAACTATAAGGAATTGAAA	ACTAAAAATATTTTGCAACCAGGAAGTTAAATCAACAACTGTTTTTATC
GTAACTATAAGGAATTGAAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_016751.1\|WP_014295802.1\|288499_289495_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|187853
NC_016751.1\|WP_014295794.1\|279259_280504_+\|hypothetical-protein	unknown	unknown	unknown
NC_016751.1\|WP_148265181.1\|288009_288495_+\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
NC_016751.1\|WP_014295813.1\|301083_301893_+\|hypothetical-protein	unknown	unknown	unknown
NC_016751.1\|WP_041638715.1\|281552_282308_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	gnl\|CDD\|187783
NC_016751.1\|WP_014295807.1\|294693_295224_-\|hypothetical-protein	unknown	unknown	unknown
NC_016751.1\|WP_014295795.1\|280546_281137_+\|hypothetical-protein	unknown	unknown	unknown
NC_016751.1\|WP_014295815.1\|303450_303612_-\|hypothetical-protein	unknown	unknown	unknown
NC_016751.1\|WP_014295816.1\|303768_304140_-\|STAS-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|379507
NC_016751.1\|WP_171814207.1\|294444_294618_+\|hypothetical-protein	unknown	unknown	unknown
NC_016751.1\|WP_014295803.1\|289497_289758_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NC_016751.1\|WP_014295814.1\|301978_303448_-\|recombinase-family-protein	unknown	unknown	gnl\|CDD\|214861
NC_016751.1\|WP_014295797.1\|282403_283783_+\|CRISPR-associated-protein-(Cas_CXXC_CXXC)	cas8b2	cls000029_cas8b2_CAS-I-B	gnl\|CDD\|187796
NC_016751.1\|WP_014295817.1\|304156_305122_-\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132913
NC_016751.1\|WP_014295810.1\|295872_297603_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_016751.1\|WP_014295812.1\|299456_300731_-\|TrpB-like-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|237087
NC_016751.1\|WP_014295811.1\|297603_299358_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_016751.1\|WP_014295800.1\|285557_287909_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|187770
NC_016751.1\|WP_014295799.1\|284850_285507_+\|type-I-B-CRISPR-associated-protein-Cas5	cas5	COG1688_cas5_CAS-I	gnl\|CDD\|273860
NC_016751.1\|WP_014295798.1\|283795_284848_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818

Protein	Function_ID	Function_description	E-value
NC_016751.1\|WP_014295802.1\|288499_289495_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187853	cd09722, Cas1_I-B, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	1.73644e-148
NC_016751.1\|WP_041638715.1\|281552_282308_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|187783	cd09652, Cas6-I-III, CRISPR/Cas system-associated RAMP superfamily protein Cas6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas6 is an endoribonuclease that generates crRNAs, predicted subunit of Cascade complex; RAMP superfamily protein; Possesses double RRM/ferredoxin fold.	7.14597e-27
NC_016751.1\|WP_148265181.1\|288009_288495_+\|CRISPR-associated-protein-Cas4	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	8.63344e-56
NC_016751.1\|WP_014295817.1\|304156_305122_-\|STAS-domain-containing-protein	gnl\|CDD\|132913	cd07042, STAS_SulP_like_sulfate_transporter, Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function. The SulP family is a large and diverse family of anion transporters, with members from eubacteria, plants, fungi, and mammals. They contain 10 to 14 transmembrane helices which form the catalytic core of the protein and a C-terminal extension, the STAS (Sulphate Transporter and AntiSigma factor antagonist) domain which plays a role in the function and regulation of the transport activity. The STAS domain is found in the C-terminal region of sulphate transporters and bacterial anti-sigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.	0.000527382
NC_016751.1\|WP_014295799.1\|284850_285507_+\|type-I-B-CRISPR-associated-protein-Cas5	gnl\|CDD\|273860	TIGR01895, conserved_hypothetical_protein, CRISPR-associated protein Cas5, subtype I-B/TNEAP. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This family is represented by TM1800 from Thermotoga maritima. It is related to TIGR01868 (CRISPR-associated protein, CT1976 family).	1.38315e-35
NC_016751.1\|WP_014295816.1\|303768_304140_-\|STAS-like-domain-containing-protein	gnl\|CDD\|379507	pfam14213, DUF4325, STAS-like domain of unknown function (DUF4325). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria, archaea, eukaryotes and viruses. Proteins in this family are typically between 99 and 341 amino acids in length. This domain is distantly related to the STAS domain.	3.6067e-09
NC_016751.1\|WP_014295812.1\|299456_300731_-\|TrpB-like-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|237087	PRK12391, PRK12391, TrpB-like pyridoxal phosphate-dependent enzyme.	0
NC_016751.1\|WP_014295803.1\|289497_289758_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	2.31181e-27
NC_016751.1\|WP_014295814.1\|301978_303448_-\|recombinase-family-protein	gnl\|CDD\|214861	smart00857, Resolvase, Resolvase, N terminal domain. The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.	5.1361e-30
NC_016751.1\|WP_014295797.1\|282403_283783_+\|CRISPR-associated-protein-(Cas_CXXC_CXXC)	gnl\|CDD\|187796	cd09665, Cas8a1_I-A, CRISPR/Cas system-associated protein Cas8a1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Large proteins, some contain Zn-finger domain; signature gene for I-A subtype; also known as CXXC_CXXC family.	7.63538e-17
NC_016751.1\|WP_014295810.1\|295872_297603_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	4.22341e-176
NC_016751.1\|WP_014295811.1\|297603_299358_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	4.87323e-180
NC_016751.1\|WP_014295800.1\|285557_287909_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	2.46814e-63
NC_016751.1\|WP_014295798.1\|283795_284848_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	2.0042e-56

>NC_016751.1|WP_014295803.1|289497_289758_+|CRISPR-associated-endonuclease-Cas2
MFVILYYDANEKRVSKFLKVCRKYLTWVQNSVFEGEITKANLEKLKYELKTKVKDNDSIIIYEFRSMNYSKREVIGIDKKENNKFI
>NC_016751.1|WP_014295802.1|288499_289495_+|type-I-B-CRISPR-associated-endonuclease-Cas1
MKETIYIFSSGELKRKDNSIVFITSDNKKRYIPIENLKEILIFGEVNITKKTLEFLSQKEIIVSFYNYYGYYMGSYYPREHYNSGYMILKQAEHYINEIKRSKLAKSFVIGATKNSLKILKYYNRREKNLEEYIKKIESLLMKLEKKSKIKEIMTIEAEIKKEYYKTFKIIIENEAFEFSKRSKRPPEDRINALISFSNSIIYNMILKEIYTTHLDPRIGYLHTTNFRRFTLNLDIAEIFKPVIGDRTIFNVINKKIINEKHFETGISGVFLNNKGKQKFLEKLEERLKQTIKHYKLNKRVSYRYLIKIELYKLEKHLIGEEEYKPFVMEW
>NC_016751.1|WP_148265181.1|288009_288495_+|CRISPR-associated-protein-Cas4
MYGSLIQSYFICKRQTWLLAHQLIGEQDNMFIEIGRFIAEKSYQNTKKEIKIDGGIIDFIKKENGKTIVAEVKKSSKNIKSAEYQLLFYLKKLKGKIDIQYAEIRIPVEKKIIKIELTEEKEKELEKIEEEIITIINKELPPMPEKIKYCKTCSYQNFCWG
>NC_016751.1|WP_014295800.1|285557_287909_+|CRISPR-associated-helicase/endonuclease-Cas3
MKSVKSNENLILAKSDGTTLLEHIEDNIVILNNLKRMLPLLPKITKLDNFWDILFSTIFFHDFGKIHKEFQKYIKGEKNLWTKQRHEIYSIPFIDKLNLDERYIKLIKKVILSHHKSFYELKYNYLKSKEDLEYEYELNWKNKTKFHPQDYEGNLKYNFDKKVIDFYIKKFDELAKKYHISVQLKNEKIKINNIRNPIEEFAYNLEKYNKEEYLQHLLLWGSLKICDHLGSAKIIEIYMFEEKHFVFLDEMKRKIEFYDHQKKCFSIKGSCLLIAPTGSGKTESAIGWVKTQLENKQGRVFYVLPYTASINAMHKRLIKNMDRSASKISNIIGILHGNISHYISIYFEEGITKNENSIRNKKIKKIIKQYKNLLSPLIVCTPFQLLKYFYGVKGFEKGFVFFSGAKLIFDEIHAYDIVTFAQIVVMLEVLKKDFLCDVMIMTATIPTFMQNILAERLNIDNIITADKKFVEKLKRHKIKIVDKNIFDFIDSNFRKIINNHNKIILVCNTVEQSQKVYMKVRDMNICSDNEIVLIHGRFNQHDRNDKEKAIYNQKTKILIGTQTIEVSLDIDYDVMITEPAPIDALLQRFGRVNRNSKKKPAPVYICRKGGEYDHYIYPINKIEKTLEVLNDVDILCEKNIGNLIDEVYPNWNDFEKKEFEDTVSLFRNSLKSLQPFSDTKETEEFYYSKFTNIKVLPACYYSKYINLMELYNFIEAEKLLVNINRNFFYKYIKEGKIEKRELVLSEDEKILKKHSFYIIKCKYNSEVGLINEYEEIKHDINFI
>NC_016751.1|WP_014295799.1|284850_285507_+|type-I-B-CRISPR-associated-protein-Cas5
MKVYRIYISSWTASFRYPNLISGFQPTLLVPPFSTINGLISSAKGDYFIPQKEKIGYVFRAKSKNIDLETIYQMEKSLKNIKSNVIKREFLVEAELFLYTDSKVIAGYFLKPKYQLLLGRSSDLATVKNIDEIEIEEKNNLKNLKGTIIPLKYGIMPGVIHALPKYFSNTIPRKNIGTQPYCILDWNYKQEEITIHALGFSDYDKKLKIDWDVYWQEP
>NC_016751.1|WP_014295798.1|283795_284848_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MNTIQGFMLIDVDVAALNNAGNDTSTTLDNAVMTKKIRKDGKEYPYVSGQAWRYWWRETLMRNFNWQISPIIREKKIAYTEADPLKYADDDIFGYMRAGKKNIIDTKTGKSKSINVTLTRVSPLKNSALIAVSYNPIVQHWSSMSRHEGDAVPYGKDEYCAIMKGMFSIDLDMVGTFSSMNKTGFQNINEDMRQLYLEKEGVFEIDDPFAKDINGNPLKLIRLPKEIREQRVKDVILALKYLSGGAKQTTNFADVTPKIIVLAILKSGNHPFSHLAKEEMGKAVFSVDALKEVINDYQDKFDNKIFVGKRKGFMDEIESDLIKLKEENLIEYGSVNKIIDKFVKTIDLGE
>NC_016751.1|WP_014295797.1|282403_283783_+|CRISPR-associated-protein-(Cas_CXXC_CXXC)
MVTGDPFVDAGGVVLEYLKNQFPEKNIIDLIDFAAEIFIYKWNGKIDSLQLNSNITHNSKRGSLEKQKKAKENVKKYFENILNSGSFSDASGYCRICGKKGKNFKVGRETFPLSGSGKFVNFHHGHENGILLCNDCITKLFFLPLAVLQMRKNLALLHVHSEKIKEYWIEKVIKKNLDNYSKNISEGILKSKLNNPKNALFEMASELINEFEAKNEYLQLFYFTNFGANPNCEIYILPNPVFRFISKVLRYCRKDWFVFIKRYYKVSKATWDYTTFEWVSEKEGKITKDYYQDEKNMVIEYLLEGKSLIGILKKFYRENFLKKKEVSSLILDYYLKEVKNMDLKQIELIKRLGKSIIEISRKENNFKKYLTMIEGANKAFQLRAIIITLIKKHYINGEEKPLITLDEYVNYLFPDGQYWSEIRDILLIYLYELLHEENIKNIDVEESNLEEPEDELIEF
>NC_016751.1|WP_041638715.1|281552_282308_+|CRISPR-associated-endoribonuclease-Cas6
MRIKVEFISDNNIILPIGFNKYIQALIYNMFSQKLRKFIHENGFESFSKRVYRFFTFSSILERGKYYKKMKIFNFGNKISFYISSPINEILEDILNNLFEKDRFSLGENILYLSSVISLGSFYTEKNIINIKMLTPLEVHKTEIINNKKKTIYYSPFSAEFEELINLNLKHKWEAFYNKELKESIKIIPLFNENKYKKIVYYGLGDKKYIIEGWMGNYKMKGDPKIIKFLYDVGLGSKNSQGFGMFEVLRE
>NC_016751.1|WP_014295795.1|280546_281137_+|hypothetical-protein
MHLKKERYFLGIGIILMFINELNTIGIILQFIGIYLLSEKTNNKKTFYYFVISLFLFYSLISFFVPQSIIMIFKNYPGLANNFDSLFTLRYSLLESIRNYFFVISLSFFIYLISLILERIAYKNLYDITLSKELSIAIKLISVEAVVLTFSYLLLAKFVIDDVIILNLLIILFVLNLTLIFLIKLFEIIGFINIEQ
>NC_016751.1|WP_014295794.1|279259_280504_+|hypothetical-protein
MGYYSKSPEEWKKLDEEKAKKDKLRQIQKRRQKINNMLIIFISILAIAFIFISKKYFPRYNFGFYVLVDKISYSIFSSDKYTYPDPLTISVSMNNSTTSPIDVKIDSFKFIIYKITGDSSETFYKFEYPKIIKYQLSPYETKKIFDLMNINPLSKIPDGKYIIYSTFNSNGKEIKLHKEIDYIHTVRYNVYLKKGFFLENEYPQLIIEARNYSEETRQFEFKGTIQIYTKKKKLIKEIPVDFGYLTLKSLEKKVNDFNIPRIEKGTYDLYFVSKQFNQAVYIPFPITDKIETKLKNISLSMDTYLFYPVNEKFQGIFYINNKDLKKERFIEITGYSLRLINLDKNTVVFNYENSDKRRIYINAGGKAIVYYLSPYDRPVTLSIPGKYQLIYTVKTNESVIERKVTVYVGINQNK
>NC_016751.1|WP_171814207.1|294444_294618_+|hypothetical-protein
MIKIKKIKLYDYEEYKENAFRKNPRLKEAYDSLEEKYKAISQEIINNMNLVKKDKDI
>NC_016751.1|WP_014295807.1|294693_295224_-|hypothetical-protein
MKKLLTALLVGGLMTGSIFAFNANAPRVYQETSGTVPMYQNYQGVPGGYLFTEENMLTVTGVIESIEENEDYPGLLEIKVKTEAGEEIELHANAYFAGSLEIGQTMEVTGWSVEINGEKIFRPAETKIDGEEVLLNGFRGSARGTGYASQTQYPAQPGAYAKPAPRGRGHGGRGRF
>NC_016751.1|WP_014295810.1|295872_297603_+|ABC-transporter-ATP-binding-protein
MKSILKYVSQQKRFIIIASLCLIGGVSAELILPYLNKIVIDDIIVGGKRNLLFPVLSGIFFITIFRALMGYSQEFLFDFTGSQISKNIKNDLFKHIQKLPFTYFDKTNTGELMSRIGEDVDNIWNALGFGISIAVEFALYFILGSLVLFYLNWKLALISLISAPAIAYLATKLENEIGKAFDKISDQAAVINTTAQENISGVRLVKAFAREKYEIMKFLKLNNENYELNLEKSRIWGKYFPTIEFLGNGALILVVTVGGALVIKGNISIGTLVAFNGYMWMIVWPMRLIGWLSNIFSQANASAKKIEKILKEDTEDFKGIKIEKLNGEIEFKNVSFKYDNEYVLKNINFKIKPGKTLAIMGPTGCGKSTLISLLSRFYEIDEGEILIDGINIKDFSLNTLRKNISYVFQDTFLFSDTVKENIKYGKDNIDDKEIISACKEAQAYDFIMKLPEKFDTIIGERGLGLSGGQKQRLTIARALIKKAPIIIFDDATSALDMDTEYELLKSIYSKELQNTKIIIAHRISAVKNADEIIYLDNGEIIERGTHDELLNMKGRYYEIYAEQFKDFEDLIEDEVV
>NC_016751.1|WP_014295811.1|297603_299358_+|ABC-transporter-ATP-binding-protein
MNLKFEKTKTILRIFSYLKPFFKQTIMVIFLMIIVMGINLINPYFFKIAIDKYIANNNLNGLIIVGVAVMFLNLLSLFISRMRIILMGKITNKIVVNIRHELYEHIQKLSFSFFDTKPVGKILARVVNDVNSLQQLFSNSITSLVPEFLTLVFVAIIMFSMNFKLALASMIILPFLLFGLFLIENISRKRWMNYRKNRSELNAFTHEDISGIRIIKSFTAENKTNKKFRFLTQKMMNSFVNAVKINDWFWAMVLVSWGIGSVVVFYLSTKMIDLNEITVGTVVAFIGYIGMFWRPIMNLSNFYNSLVTNISAAERIFEILDTKPLIVNSKNARIMPEIKGKVEFKNVYFSYDKEIILKDMSFKVNAGETIALVGPTGAGKTTVINLISRFYDPQKGKILIDGIDIKNVDLESLRSQMGIMLQDTFLFSDTIKENIRYGKLDATDEEIINVAKAVHAHEFIMKLEKGYDTKVNERGVRLSIGERQLISFARALLANPKILILDEATSNIDTHTEKLVQDGIKKLLKGRTSFVIAHRLSTIRNADRIFYIDNGKIIESGNHDELMSKKGFYYNLYLSQFKFLEIGA
>NC_016751.1|WP_014295812.1|299456_300731_-|TrpB-like-pyridoxal-phosphate-dependent-enzyme
MGKRERVYLSVEEMPKYWYNALADLPFELDPPLNPQTKEIMKPEELEAIFPKPIVEQEVTKERYIKIPDAVLEEYAIFRPTPLIRATNLEEYLETPARIYYKYEGVSPTGSHKTNTSIPQAYYNKISGVDTLVTETGAGQWGSALSYAGLKFGLNIEVYMVKTSFEQKPMRKHLINLFNGKVTPSPSLDTEFGKKMISMDEDNPGSLGIAISEALEVVFTKKNAKYALGSVLNHVLLHQSIIGLEIKKQLEKINESADVVIGCHGGGSNLGGTILPFVPEKLSNDNIKFLACEPKSCPSLTEGEYRYDNGDTAGLTPLMKMYTLGKEFIPPKIHAGGLRYHGSAPIIARLKHEGLLDAVAFSQDETFEAAKLFAKLEGIVPAPESSHAIAGAIKEAIEAKENKEEKVIVFTLSGHGLLDLTAYS
>NC_016751.1|WP_014295813.1|301083_301893_+|hypothetical-protein
MKINTEIIDTYLMEKNLKKISNNKIFSLIENGKILFEAPPEESYQKIKNTYNLFKNIIFSFKPCNYNIWKNIFEISDNTDNSFIIFPIIGAPSPYEAMIRYDENGNTLMIFDIYLLGKNIDNLPKLKENISLLITHELAHYYIHQRFQYPQKIENQLKYLFFDEGFAHFLSYSNNIEQINWNEKKYIKKREYSYEMLKEKLKNKLDKNLLIKGITANNYWDKYIAISGMFAIIDFWHSNNKKLDSLKLLYKKGPEYLWNFWEINYLTKT
>NC_016751.1|WP_014295814.1|301978_303448_-|recombinase-family-protein
MKKAAAYARVSTKDQSKISIEGQFKTIENFAKQYGFKIVDYFSDKDSGKKMKREQLDILLENAYKGKYDVILVEKYDRFSRAGIDGQVIIQDLEKNYNVLVIAALEPFDVSTPQGRFTRTIILASYTLEGEMISQRTKMRMKDIASKKYWMGGNPPFGFDSYQIIDDEGKKRRKLKINEEQAKIVREIFELRLKNIGYSEIAKRLNERGIKNARGNLWRGSTILDMINNPLYAGIYIYGKGNKRSRKRSSELKDAVIIENFVEPIISREVFEEVNRKNGKLTNALTRHKYLLKGLIYTENGDRMVGAGGKTPSYVSSAWHSGKTRGYIGIAKSKIEREVFLHVKHRLLEFDFDDDEFWEEFAETLNYVKKLKMNIENEKVLALRKRLEEIEEQLINITNAIKAGIINDEIKKENELLTKEKNDIINQIKMADMHFDTETPERLKKKWREKIQALENYDEDKLIEIYNQLIERIIVYKDKFIEINFKQIE
>NC_016751.1|WP_014295815.1|303450_303612_-|hypothetical-protein
MIIVRVLVSEEDLDLLKEFGFMFWDERKLNQDELYAFYKFLLLLQKVSKEGSE
>NC_016751.1|WP_014295816.1|303768_304140_-|STAS-like-domain-containing-protein
MLIKLFEMYNTDILGTRYEGEKLRIILKKYLENTKDIIYIDFNNINVVTHSFLDQAVGTLFSEYGPIVFKRIKFKNAQNSVKSIGKLIKIDRVRDFIFKPDKYAYKKVPLHILNHFKSNYHRI
>NC_016751.1|WP_014295817.1|304156_305122_-|STAS-domain-containing-protein
MEVIELPNKVTLDNVLTLINLTQQSFNNGNEILFDFSKVSFVDPFGANFLVLLIKNLENKGIKINVNILELNSDVFDYLNRMNFFDKLGIDYLEYPHVKHDSNNRFLEMKEIYSIEEIPDVEKHFQKVIKDEDLARFLGYQIRELLDNIFSHAESSIGALLMSQKYHSSSTEKIIFSVGDLGVGIPATLKPFFQNISMDHLLIEKSLDFGVSSKKNSGIYFGSDHRGAGLYYIKRYVQMNKWNLLVISKKGLYFIKRGKETIKKEFKYNIIDGTLFALSINNENIFDYDILHEMLLNETSEYLNKNVNSDIILDEDFDEEW

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Crispr_ID: NC_016751_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016751_3

396000-397721

TypeIII

Consensus_repeat	Method
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	PILER-CR
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	CRISPRCasFinder
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	CRT

22 spacers

PrimPol,cas1,cas2,csx1,csm6,cas6,cmr6gr7,cmr5gr11

The CRISPR arrays of NC_016751_3

>merge|NC_016751|3|396000-397721|PILER-CR,CRISPRCasFinder,CRT
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAACAATCCCATTCAACGTTTAATACTTTTTTAAATAACCAATTATATCCGAATATCACTACTCTCTGAAAGAGATAGAAACAATCTTTTCTATATACTTTGCACCAACCTTTATATTGCCAATCCGAATATCACTACTCTCTGAAAGAGATAGAAACAGCGTAACGCTGTTTTCTGTAACCCGTCTTGCTTTTTACAAATCCGAATATCACTACTCTCTGAAAGAGATAGAAACTCGTTGCCCTTTCTGAGAATAACCAGAAAAAACCACTTTAATCCGAATATCACTACTCTCTGAAAGAGATAGAAACACATTCTTTATCTTGACTGTCTTTACCTTCATCATAACTATCCGAATATCACTACTCTCTGAAAGAGATAGAAACTCTTTTCAACTTCTGCTAAATTGTGAGCTAAGTTTCGTTCTATCCGAATATCACTACTCTCTGAAAGAGATAGAAACTCTTCTTCCAATTCTTTTAATTCTTTTTTGTATTGCTTTAAATCCGAATATCACTACTCTCTGAAAGAGATAGAAACAATAAATTCTACACCATATGGTTTTTTCATTTTACCTAATAATCCGAATATCACTACTCTCTGAAAGAGATAGAAACAGTATTTATTACCTGTCTTTTATGCGTTTTATTGTACTTTAATCCGAATATCACTACTCTCTGAAAGAGATAGAAACTTTGATTTTTAATTGTAATATGTAGAACAATCTTTATTCTGATCCGAATATCACTACTCTCTGAAAGAGATAGAAACATATCTAACAACATAACCTTTAATTAAACCACTATTCTTTTATCCGAATATCACTACTCTCTGAAAGAGATAGAAACTTCCAGCTTTTCAATGTGTGGGAATATTATATACTCCCACTCATCCGAATATCACTACTCTCTGAAAGAGATAGAAACAGTATATAATACTCCCAATCGTAACCGACAAAAATTTTACATCCGAATATCACTACTCTCTGAAAGAGATAGAAACAAATATTGAAATAACTATAATAAGACTCTTGTAAACACCAATCCGAATATCACTACTCTCTGAAAGAGATAGAAACAATATTATTCTACCTAACCTTTCACCTTCTATTCTATCTCATCCGAATATCACTACTCTCTGAAAGAGATAGAAACATGAGGTGGAACATGCCACCTCAAAAAATTATATCATATAAATCCGAATATCACTACTCTCTGAAAGAGATAGAAACAATGCTTGATATGCATCTTCCCAACTATTATATTTAATCTATCCGAATATCACTACTCTCTGAAAGAGATAGAAACTGTTGAATCACTAACTCAGCGCCAGTTATGCCGTCGAAGTATCCGAATATCACTACTCTCTGAAAGAGATAGAAACGAATTACTTCTCCTCTGGCCTTTTTGCGAACCCCATGATGTATCCGAATATCACTACTCTCTGAAAGAGATAGAAACGTTTATCTATTTCTTCAACCATTAAATTGATTATTGCATCATCCGAATATCACTACTCTCTGAAAGAGATAGAAACCGTTTTTAAACAACAAACCTCTACCAGTGCGATTAAAAACTATCCGAATATCACTACTCTCTGAAAGAGATAGAAACTTTGATAGTGTAGTATAATCAATATCACGTTGAAGATGTTTATTCGAATATCACTACTCTCTGAAAGAGATAGAAAG

>NC_016751|3|3|396000-397721|PILER-CR
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	AATCCCATTCAACGTTTAATACTTTTTTAAATAACCAATTAT
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	AATCTTTTCTATATACTTTGCACCAACCTTTATATTGCCA
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	AGCGTAACGCTGTTTTCTGTAACCCGTCTTGCTTTTTACAA
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	TCGTTGCCCTTTCTGAGAATAACCAGAAAAAACCACTTTA
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	ACATTCTTTATCTTGACTGTCTTTACCTTCATCATAACT
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	TCTTTTCAACTTCTGCTAAATTGTGAGCTAAGTTTCGTTCT
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	TCTTCTTCCAATTCTTTTAATTCTTTTTTGTATTGCTTTAA
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	AATAAATTCTACACCATATGGTTTTTTCATTTTACCTAATA
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	AGTATTTATTACCTGTCTTTTATGCGTTTTATTGTACTTTA
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	TTTGATTTTTAATTGTAATATGTAGAACAATCTTTATTCTG
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	ATATCTAACAACATAACCTTTAATTAAACCACTATTCTTTT
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	TTCCAGCTTTTCAATGTGTGGGAATATTATATACTCCCACTC
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	AGTATATAATACTCCCAATCGTAACCGACAAAAATTTTAC
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	AAATATTGAAATAACTATAATAAGACTCTTGTAAACACCA
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	AATATTATTCTACCTAACCTTTCACCTTCTATTCTATCTC
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	ATGAGGTGGAACATGCCACCTCAAAAAATTATATCATATAA
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	AATGCTTGATATGCATCTTCCCAACTATTATATTTAATCT
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	TGTTGAATCACTAACTCAGCGCCAGTTATGCCGTCGAAGT
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	GAATTACTTCTCCTCTGGCCTTTTTGCGAACCCCATGATGT
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	GTTTATCTATTTCTTCAACCATTAAATTGATTATTGCATC
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	CGTTTTTAAACAACAAACCTCTACCAGTGCGATTAAAAACT
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	TTTGATAGTGTAGTATAATCAATATCACGTTGAAGATGTTT
ATTCGAATATCACTACTCTCTGAAAGAGATAGAAAG

>NC_016751|3|3|396000-397721|CRISPRCasFinder
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	AATCCCATTCAACGTTTAATACTTTTTTAAATAACCAATTAT
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	AATCTTTTCTATATACTTTGCACCAACCTTTATATTGCCA
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	AGCGTAACGCTGTTTTCTGTAACCCGTCTTGCTTTTTACAA
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	TCGTTGCCCTTTCTGAGAATAACCAGAAAAAACCACTTTA
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	ACATTCTTTATCTTGACTGTCTTTACCTTCATCATAACT
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	TCTTTTCAACTTCTGCTAAATTGTGAGCTAAGTTTCGTTCT
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	TCTTCTTCCAATTCTTTTAATTCTTTTTTGTATTGCTTTAA
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	AATAAATTCTACACCATATGGTTTTTTCATTTTACCTAATA
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	AGTATTTATTACCTGTCTTTTATGCGTTTTATTGTACTTTA
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	TTTGATTTTTAATTGTAATATGTAGAACAATCTTTATTCTG
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	ATATCTAACAACATAACCTTTAATTAAACCACTATTCTTTT
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	TTCCAGCTTTTCAATGTGTGGGAATATTATATACTCCCACTC
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	AGTATATAATACTCCCAATCGTAACCGACAAAAATTTTAC
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	AAATATTGAAATAACTATAATAAGACTCTTGTAAACACCA
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	AATATTATTCTACCTAACCTTTCACCTTCTATTCTATCTC
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	ATGAGGTGGAACATGCCACCTCAAAAAATTATATCATATAA
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	AATGCTTGATATGCATCTTCCCAACTATTATATTTAATCT
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	TGTTGAATCACTAACTCAGCGCCAGTTATGCCGTCGAAGT
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	GAATTACTTCTCCTCTGGCCTTTTTGCGAACCCCATGATGT
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	GTTTATCTATTTCTTCAACCATTAAATTGATTATTGCATC
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	CGTTTTTAAACAACAAACCTCTACCAGTGCGATTAAAAACT
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	TTTGATAGTGTAGTATAATCAATATCACGTTGAAGATGTTT
ATTCGAATATCACTACTCTCTGAAAGAGATAGAAAG

>NC_016751|3|3|396000-397721|CRT
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	AATCCCATTCAACGTTTAATACTTTTTTAAATAACCAATTAT
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	AATCTTTTCTATATACTTTGCACCAACCTTTATATTGCCA
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	AGCGTAACGCTGTTTTCTGTAACCCGTCTTGCTTTTTACAA
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	TCGTTGCCCTTTCTGAGAATAACCAGAAAAAACCACTTTA
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	ACATTCTTTATCTTGACTGTCTTTACCTTCATCATAACT
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	TCTTTTCAACTTCTGCTAAATTGTGAGCTAAGTTTCGTTCT
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	TCTTCTTCCAATTCTTTTAATTCTTTTTTGTATTGCTTTAA
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	AATAAATTCTACACCATATGGTTTTTTCATTTTACCTAATA
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	AGTATTTATTACCTGTCTTTTATGCGTTTTATTGTACTTTA
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	TTTGATTTTTAATTGTAATATGTAGAACAATCTTTATTCTG
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	ATATCTAACAACATAACCTTTAATTAAACCACTATTCTTTT
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	TTCCAGCTTTTCAATGTGTGGGAATATTATATACTCCCACTC
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	AGTATATAATACTCCCAATCGTAACCGACAAAAATTTTAC
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	AAATATTGAAATAACTATAATAAGACTCTTGTAAACACCA
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	AATATTATTCTACCTAACCTTTCACCTTCTATTCTATCTC
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	ATGAGGTGGAACATGCCACCTCAAAAAATTATATCATATAA
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	AATGCTTGATATGCATCTTCCCAACTATTATATTTAATCT
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	TGTTGAATCACTAACTCAGCGCCAGTTATGCCGTCGAAGT
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	GAATTACTTCTCCTCTGGCCTTTTTGCGAACCCCATGATGT
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	GTTTATCTATTTCTTCAACCATTAAATTGATTATTGCATC
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	CGTTTTTAAACAACAAACCTCTACCAGTGCGATTAAAAACT
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	TTTGATAGTGTAGTATAATCAATATCACGTTGAAGATGTTT
ATTCGAATATCACTACTCTCTGAAAGAGATAGAAAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_016751.1\|WP_041638737.1\|389202_390042_-\|phosphate-ABC-transporter-permease-subunit-PstC	unknown	unknown	gnl\|CDD\|223646
NC_016751.1\|WP_014295918.1\|397860_399501_+\|tetratricopeptide-repeat-protein	PrimPol	COG4951_PrimPol_CAS-I:CAS-III	gnl\|CDD\|227287
NC_016751.1\|WP_148265128.1\|406882_407641_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr6	cmr6gr7	COG1604_cmr6gr7_CAS-III-B	gnl\|CDD\|224520
NC_016751.1\|WP_014295912.1\|387619_388402_-\|phosphate-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224042
NC_016751.1\|WP_014295923.1\|404945_406082_-\|CRISPR-associated-protein	csm6	cd09742_csm6_CAS-III-A:CAS-III-D	gnl\|CDD\|187873
NC_016751.1\|WP_014295911.1\|386943_387606_-\|phosphate-signaling-complex-protein-PhoU	unknown	unknown	gnl\|CDD\|273990
NC_016751.1\|WP_014295924.1\|406074_406896_-\|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	gnl\|CDD\|273848
NC_016751.1\|WP_014295915.1\|390085_390916_-\|phosphate-ABC-transporter-substrate-binding-protein-PstS-family-protein	unknown	unknown	gnl\|CDD\|270284
NC_016751.1\|WP_014295926.1\|407637_407991_-\|type-III-B-CRISPR-module-associated-protein-Cmr5	cmr5gr11	pfam09701_cmr5gr11_CAS-III-B	gnl\|CDD\|378242
NC_016751.1\|WP_014295917.1\|394057_395521_+\|DUF2828-family-protein	unknown	unknown	gnl\|CDD\|371536
NC_016751.1\|WP_014295922.1\|403243_404935_-\|DUF1874-domain-containing-protein	csx1	pfam09455_csx1_CAS-III	gnl\|CDD\|378186
NC_016751.1\|WP_014295919.1\|399513_400518_+\|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|376633
NC_016751.1\|WP_014295916.1\|391137_393309_+\|sodium-translocating-pyrophosphatase	unknown	unknown	gnl\|CDD\|376979
NC_016751.1\|WP_041638444.1\|384147_385254_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238537
NC_016751.1\|WP_014295921.1\|400813_402733_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|240017
NC_016751.1\|WP_156865381.1\|402827_402983_-\|hypothetical-protein	unknown	unknown	unknown
NC_016751.1\|WP_014295920.1\|400518_400797_+\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|187856
NC_016751.1\|WP_014295913.1\|388391_389216_-\|phosphate-ABC-transporter-permease-PstA	unknown	unknown	gnl\|CDD\|223654
NC_016751.1\|WP_014295910.1\|386255_386933_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_016751.1\|WP_014295909.1\|385297_386254_-\|two-component-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|274368

Protein	Function_ID	Function_description	E-value
NC_016751.1\|WP_041638737.1\|389202_390042_-\|phosphate-ABC-transporter-permease-subunit-PstC	gnl\|CDD\|223646	COG0573, PstC, ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism].	9.03929e-65
NC_016751.1\|WP_014295918.1\|397860_399501_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|227287	COG4951, COG4951, Uncharacterized protein conserved in bacteria [Function unknown].	4.54484e-17
NC_016751.1\|WP_148265128.1\|406882_407641_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr6	gnl\|CDD\|224520	COG1604, COG1604, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	1.54549e-41
NC_016751.1\|WP_014295912.1\|387619_388402_-\|phosphate-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224042	COG1117, PstB, ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism].	6.2856e-164
NC_016751.1\|WP_014295923.1\|404945_406082_-\|CRISPR-associated-protein	gnl\|CDD\|187873	cd09742, Csm6_III-A, CRISPR/Cas system-associated protein Csm6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Protein of this family often fused to HTH domain; loosely associated with CRISPR/Cas systems; also known as APE2256 family.	1.6829e-10
NC_016751.1\|WP_014295911.1\|386943_387606_-\|phosphate-signaling-complex-protein-PhoU	gnl\|CDD\|273990	TIGR02135, Uncharacterized_protein, phosphate transport system regulatory protein PhoU. This model describes PhoU, a regulatory protein of unknown mechanism for high-affinity phosphate ABC transporter systems. The protein consists of two copies of the domain described by pfam01895. Deletion of PhoU activates constitutive expression of the phosphate ABC transporter and allows phosphate transport, but causes a growth defect and so likely has some second function. [Regulatory functions, Other, Transport and binding proteins, Anions].	2.98118e-50
NC_016751.1\|WP_014295924.1\|406074_406896_-\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	8.27481e-14
NC_016751.1\|WP_014295915.1\|390085_390916_-\|phosphate-ABC-transporter-substrate-binding-protein-PstS-family-protein	gnl\|CDD\|270284	cd13566, PBP2_phosphate, Substrate binding domain of putative ABC-type phosphate transporter, a member of the type 2 periplasmic binding fold superfamily. This subfamily contains uncharacterized phosphate binding domains found in PstS proteins that serve as initial receptors in the ABC transport of phosphate in eubacteria and archaea. After binding the ligand, PstS interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The PstS proteins belong to the PBPII superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	4.76707e-92
NC_016751.1\|WP_014295926.1\|407637_407991_-\|type-III-B-CRISPR-module-associated-protein-Cmr5	gnl\|CDD\|378242	pfam09701, Cas_Cmr5, CRISPR-associated protein (Cas_Cmr5). CRISPR is a term for Clustered, Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family, represented by TM1791.1 of Thermotoga maritima, is found in both archaeal and bacterial species.	3.63055e-23
NC_016751.1\|WP_014295917.1\|394057_395521_+\|DUF2828-family-protein	gnl\|CDD\|371536	pfam11443, DUF2828, Domain of unknown function (DUF2828). This is a uncharacterized domain found in eukaryotes and viruses.	6.17286e-96
NC_016751.1\|WP_014295922.1\|403243_404935_-\|DUF1874-domain-containing-protein	gnl\|CDD\|378186	pfam09455, Cas_DxTHG, CRISPR-associated (Cas) DxTHG family. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. The family describes Cas proteins of about 400 residues that include the motif [VIL]-D-x-[ST]-H-[GS]. The CRISPR and associated proteins are thought to be involved in the evolution of host resistance. The exact molecular function of this family is currently unknown.	1.79529e-33
NC_016751.1\|WP_014295919.1\|399513_400518_+\|CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|376633	pfam01867, Cas_Cas1, CRISPR associated protein Cas1. Clustered regularly interspaced short palindromic repeats (CRISPRs) are a family of DNA direct repeats found in many prokaryotic genomes. This family of proteins corresponds to Cas1, a CRISPR-associated protein. Cas1 may be involved in linking DNA segments to CRISPR.	1.34539e-116
NC_016751.1\|WP_014295916.1\|391137_393309_+\|sodium-translocating-pyrophosphatase	gnl\|CDD\|376979	pfam03030, H_PPase, Inorganic H+ pyrophosphatase. The H+ pyrophosphatase is an transmembrane proton pump involved in establishing the H+ electrochemical potential difference between the vacuole lumen and the cell cytosol. Vacuolar-type H(+)-translocating inorganic pyrophosphatases have long been considered to be restricted to plants and to a few species of photo-trophic bacteria. However, in recent investigations, these pyrophosphatases have been found in organisms as disparate as thermophilic Archaea and parasitic protists.	0
NC_016751.1\|WP_041638444.1\|384147_385254_-\|hypothetical-protein	gnl\|CDD\|238537	cd01117, YbiR_permease, Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate sodium, sulfate, arsenite and organic anions. A typical ArsB/NhaD permease is composed of 8-13 transmembrane domains.	2.61722e-55
NC_016751.1\|WP_014295921.1\|400813_402733_+\|hypothetical-protein	gnl\|CDD\|240017	cd04659, Piwi_piwi-like_ProArk, Piwi_piwi-like_ProArk: PIWI domain, Piwi-like subfamily found in Archaea and Bacteria. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The central component of the RNA-induced silencing complex (RISC) and related complexes is Argonaute. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the 5' anchoring of the guide RNA and the other, the catalytic site for slicing. This domain is also found in closely related proteins, including the Piwi subfamily, where it is believed to perform a crucial role in germline cells, via a similar mechanism.	4.77658e-15
NC_016751.1\|WP_014295920.1\|400518_400797_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	4.13907e-26
NC_016751.1\|WP_014295913.1\|388391_389216_-\|phosphate-ABC-transporter-permease-PstA	gnl\|CDD\|223654	COG0581, PstA, ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism].	1.43516e-79
NC_016751.1\|WP_014295910.1\|386255_386933_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.33194e-73
NC_016751.1\|WP_014295909.1\|385297_386254_-\|two-component-sensor-histidine-kinase	gnl\|CDD\|274368	TIGR02966, Phosphate_regulon_sensor_protein_PhoR, phosphate regulon sensor kinase PhoR. Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems].	2.61077e-41

>NC_016751.1|WP_014295917.1|394057_395521_+|DUF2828-family-protein
MNKNFMEALKEEGNVYYTGNGALSLKNSGNSLVDFFYRCGILMNQPKRFEELFLNAFAEDKEKAIKILFYSRDVRGGQGVRRTFRHILKKLGNLYPEIAVQIIKYVPEYGRWDDLYAFVGTKVETEAFEFMYKQIIEDVKNYKDNKPISLLAKWLKSENTSSKHSVKLAKITRKYFKMDSKTYRKMLSELRKYIKIVERDMSENKWDNIEYEIVPSRAMKKYHRAFYKHDAERYEKYLEEVKNNKKKINAGTLYPHDIVKMVLKEENETAEMLWKNLPDYGIEEDAIAVVDTSGSMYGCGESLIPITVAVSLGIYFAERNKGKFKNYFITFSEKPELPEIKGETLYEKVQTLSQAYWDANTNIIKVFELILETAKKGGYTIEDIPEKIYIISDMQFDMAVSDNSKTNFEAIKEMYEKAGYPMPQLIFWNVSSYGNDVPVKFDENGTALISGYNPVILKYILTGKDINPYEIMENVINSERYKNIHIN
>NC_016751.1|WP_014295916.1|391137_393309_+|sodium-translocating-pyrophosphatase
MLLYLLITVPLLALLFAMYNYRSVLKLDEGTERMSEIALAIREGTRTFINHEYTTVGIYIVFISIILAIVTDINTGIAFVIGAIMSGSAGYVGMKMATYANVRVSNSARTTKNIGKTLKVAFQGGSVMGLSVAGFALLGLIIIYIIFGKWQGLLNIENIKVIRNWLGISYIPFAMVISGYALGCSVIAMFDRVGGGIYTKAADMGADLVGKTELALPEDDPRNPATIADNVGDNVGDVAGLGADLLESYIGAIISSVILILYASFILSKNNSIISYETTYKLIVYPVIFAIMGLIGAMLGIFYVIKKKSTDNPHKELNTSLLFSATFTGIFTLIAGYYYLKDLPQNELKLLGFKYGIFSPWLSAMLGIISGIIIGLLAEYYTSDKYKPTQELATFAKGGPAIIISKGMALGMKSVLYPVFMLMFGILLANYFSGLYGVAMAAMGMLSFVAATVSVDSYGPIADNAGGISEMAELDPEVRKITDMLDSVGNTTAAIGKGFAIGSAAFAALSLFASYVYSQINPDMAVDLKTLLNINLISPRTIAGALFGAALPFYFSAYLIDAVVNAAEKMVEEIRRQFREIPGLMEGKNKPDYNKCIKISSEGALKEMKTPALIAVLTPIISGFIFGTEFVGGLLAGTTFSGVMLAIYTANAGGAWDNAKKYIENNNLEGEGKGTEAHKASVVGDTVGDPLKDTVGPSLDILIKIMAVTSLITVSVFKIYHLF
>NC_016751.1|WP_014295915.1|390085_390916_-|phosphate-ABC-transporter-substrate-binding-protein-PstS-family-protein
MKKSIGLFLVLVLVILGKGFAERLIIKGSNTVFPIAQLWIEELKKNNPEIEITLEGAGSSTGIAALFNGTTDIANASRFLKKKEIDKMNREGLYFAPIVVGYDGIAIIVNPRLKINNITLKTLKGIYTGKLRTWNQVDPNLPKKRIVIYSRNTASGTFETFEKKVLDGEKMFPTVKMVESTQFEIDQVARNPYAIAYVGVGYVSEKVKVLTVEGVKPTKLNILTAKYPISRPLYMFIDVTNGWPESGPVKEYITFGLSKKGQELVEKAGYVAAYGF
>NC_016751.1|WP_041638737.1|389202_390042_-|phosphate-ABC-transporter-permease-subunit-PstC
MLINITAFLGIGALILIFVFIIHESIPALKSAGIEIFTSFNWYPTYDEPEYGILTMLINSILLTIFTSLIVIPLGYIVAFFMYEYAKPFEKRLIKSAIDLLSGVPSVIIGMFLVIYLSPLMLEIGAWSPENMLLAVSGLVLLSFPYTASLMEEALSSVDKSLKEGALALGSARFTAVFKIVTLAALPGIVNSIILTINRVIGETMVVLMAAGGANMLPQSIFDPVRPLTAAIASEMGEVEIGSIHYSALFVSGLVLLVISVILTISSKNFVRSYENGKR
>NC_016751.1|WP_014295913.1|388391_389216_-|phosphate-ABC-transporter-permease-PstA
MARDKVVSVVFRSISYLLFVIVFIIFAFVIFDGIRFFSFGFFIQFPKDMMTEGGIFPAILGSFYLLFLTLAISIPVGVLTGIFLSEYGDNRIGRLLDIAITSLSGVPSIVFGLFGLALFSITMGLKTSLISGALTLSVMALPIISSATKEALKAIPDVLRESAYALGAKKTEMIFKVILPAAKSRILTAVLIGSGRVMGETAPVLLTAAVFYSTQLPGSIKDPVMTLPTHIYNIVMAYGADAQWMAKGTASVLMIVVLIIYSFAFRLRRKINGN
>NC_016751.1|WP_014295912.1|387619_388402_-|phosphate-ABC-transporter-ATP-binding-protein
MATETIIKSCNDIITVRNFNAWYGDKQALKDINITIKENKISAIIGPSGCGKSTLLRSINRMNDTIPEYRISGEICFEGKNIYDSKIDLTIYRKKVGMVFQKPVPFPMSIYENVAFGLKIHGVKDKQKIDEIVEISLRKAALWKEVKDELHKSALTLSGGQQQRLVIARALAVDPEVILLDEPTSALDPIATQRIELLLEELSEKYTIVIVTHNLSQAIRISDYLYFMYQGELIESGKTSEIIENPQNQLTEDYLNGRIG
>NC_016751.1|WP_014295911.1|386943_387606_-|phosphate-signaling-complex-protein-PhoU
MKNIHHFENEILILKADISKMLSLILESFNMSIKALEGNDKMLAKRVLDLDDKIDNLNRKIEEEVYQLIARYNPLAKELRYIITMIKFSNNLERIGDLSCNIAQKTFEFEELNEHAKLNENMLKMIGLSLEMLKEVFKAFNERNIELAIEIWKKDNIIDELEIENRKNILEDFKNGKYDERSIIPYVLIARDIERISDQVTNLCEEIVYIEKGEEILKYI
>NC_016751.1|WP_014295910.1|386255_386933_-|response-regulator-transcription-factor
MASILIVEDDSDIREILRTYLEIEKYDVFEVENIQEMKAFLSKNHVDIILLDIMLPDGDSVEILPYIRSANRNTGIIIVSAKNTDRDKIYGIESGADDYVTKPFNPREVVARVRALLKRLKNEDEKLEFGPLEIFSGNYVVKHKNNVIDLTAKEFEILLLLAKNNKKIFSREEIIDRIWFDSDYITDRVVDVHISMIRSKIGKGWIKTVRNFGYKFNPQAWEVEE
>NC_016751.1|WP_014295909.1|385297_386254_-|two-component-sensor-histidine-kinase
MDTKILDFIEEAYIELDKIKVKEINKSAMDFGFKKGIELINIITFNEIDEFIKAIINNEDFEIETTVYFFQGESKYCFLKYLSNYNVLIIKDQTEKELVKKVKSDFITSLSHEIRTPLSVAKGNIYLAMDILNDNEAIKPLKKVRDSINKIERILDQLTLLSLAEFENYVLKFEIFDPQKIFEDVKNDLEEKIKRKNVSIDLDLNVEMLKGDPFVIYTILRNLISNAVKYSYENSRVYVSIFEDKIIVKDEGIGIRDEEKERVFERFYRGVDAKKYARGSGLGLAIVKYLCNLAGYKIEYNSQWMVGSTFIIHLNTDM
>NC_016751.1|WP_041638444.1|384147_385254_-|hypothetical-protein
MIAIDRVKKYIMEEKLIVFLFVFLIIISFMYKISPVQYPELINWKTIFFLSGLLLITKSIELSNYFHHIAIFMVKKAHYERNLVYFLIIISTFLAMILTNDITLFIVIPLTIKLKKLVNFDFSRIIILEIIAVNIGSSLTPIGNPQNIFIWHNYGTGVFNFILKMMPFFLLEFFLLIVYATFLVKNKKMEIVISDEKYDNNAFFNSLIILLMYIISSNYEDFFYLFLGVIFVYYLITKKSVISKCDWNIILLFILFFINFNILSMIPEIKYFIEHFGLNNGKNLFLFSTGLSQIISNVPATIFLSNYTDNWYYLSYGVNLAGTGFIIGSLANIIGLRISKIENGMKTYHKYAIPYFLISLLLISLIIK
>NC_016751.1|WP_014295918.1|397860_399501_+|tetratricopeptide-repeat-protein
MNFKELAFKAEEDFDFEKAIEYYKKAFNELTINDDSLIRYANLLFDFQKFEEAEPIFEKIVSEINDSEYMSKLAIIYEENNKFEKALKIYKELGIESKVKELSDKIELKAPSQNAIKRFMTLFSGREDVFSIQYEGGYRPIRRPLNFHDIKDHFSGKKTLGIYLLKKNDTVKFAAYDIDIKKHYLNREDKFVYEENSKKVAKRLSRELNLENIIHYFEFTGNRGYHIWIFFDIPVSAYKIKYIMEKILDRIELEEGIDVEIFPKQTSLNGGLGNLIKVPLGVHKKTGKKCLFVDNDFNVIENQIEFLNNIKENKATEIDKLFREIFNENDYDDFNVTYKKRTTSSKNSASKKIKSSIRKTLPKSNKNIFTQMIEGCHILKQINEKIEKEAYITEEEEMIFIKSLANLENSKKFIEMKLSQTINFSKKRIDMIIKQSLGVPITCEEIRKIILNKDISLSLENCTCKFQGNYNSPYAIVENIEEMFLDKIDINDIAKKIVEKNAEKFEIEKEIKNLKRMIAKKMGDSKELRTEIGTIKRFGDDIEIIL
>NC_016751.1|WP_014295919.1|399513_400518_+|CRISPR-associated-endonuclease-Cas1
MILYITEQGAVLSKREGRLVISKENSIISEIPLNKIEKINLMGNISLTTPIISYFLDHEIEVIFMTKTGKYRGKLYTDEYRNVLLRLKQYERSYDEKFKLKISKAIVKGKLKNSYDFLINRSRYLPKGTLSKEIASIRKIIEKVDKGKNIDEVRGFEGIGSKYYFEGFKKLIKNENFKFEKRIMHPPRDPVNAMLSFGYYLLYNEVMAAINIVGLDPYFGNLHTIEISKKSLLFDLVEEFRNIIIDNFILKLINRNEISKDDFNKKDENIIYFTDEGMKKFISKYEEMISQKMRYHLDEETNYIRTIFQKQARHYARVVIGDEEEYIPFYRVGN
>NC_016751.1|WP_014295920.1|400518_400797_+|CRISPR-associated-endonuclease-Cas2
MFYVVSYDITNDKRRRKVVKYLESYGVRVQYSVFETELNQDQLKKLIKGLKKQIKKDEDTIRIYPISKESRRYIVTIGIDKGKYYDKDFLII
>NC_016751.1|WP_014295921.1|400813_402733_+|hypothetical-protein
MYLNLYKIDIPKKIKRLYFYNPDMEPKLFARNLSRVNNFKFQDSNDLVWIEIPDIDFQITPKNVFQYKVEKEEIIKEEEDKKLFVKTLYKYIKKLFLDNDFYFKKGNNFISNSEVFSLDSNENVNAHLTYKIKIHNISNEYYLSILPKFTFLSKEPALESAIKSGYLYNIKSGKSFPYISGLDGILKIDIGNNQIVEVAYPENYLFNFTTRDAEKYGFSKEVHEIYKNKVFEGFKKIPKTLGFLNKITNLNENYQLKDGYKIFINVIYKFKNGESRYAKDVFKYSFYKNEQPLKAIFFFSSKKQFFEVQKSLKELFHNKHSVFYRAAAELGFSKVEFLRDSKTKSSAFLYNPEEFTVKNTEFINQIEDNVMAIVLLDKYIGNIDPLVRNFPDNLILQPILKEKLEDIKPFIIKSYVYKMGNFIPECKPFILKKMEDKEKNLYIGIDLSHDTYARKTNLCIAAVDNTGDILYIGKHKNLELNEKMNLDILEKEYIKAFEKYIEKFNVSPENVFILRDGRFIEDIEIIKNFISYNDTKYTLVEVNKNTNINSYDDLKEWIIKLDENTYIYYPKTFLNQKGVEVKILENNTDYTIEEIIEQIYLLTRVAHSTPYTNYKLPYPLHIANKVALTDYEWKLYIPY
>NC_016751.1|WP_156865381.1|402827_402983_-|hypothetical-protein
MKSYKDLMQELLEDEKFREIHFKKEALHHFLDEIVKDEKKKGKFIEALNLL
>NC_016751.1|WP_014295922.1|403243_404935_-|DUF1874-domain-containing-protein
MEKILLLSFLGKGRYNESLYYRLEAENKKAKSYLSPLANAYLEKERGNDVEIKFFITKEVKENFLENPNSEHGQNINNEINNLHQKGISVTFENIPEGRNYNELEEIISIIKKSISEFSEKEIIFDLTHGLRHISTFTTGVIFYLKNLQQDFEEKNIILYYGAYDIRKEFKNKPPEVPILNISSTLELSNLTLALEEFKEYGITKRIEKALRNIQKLVATNKLCNVNKLKFSSLSTELSNFNNIIKIPASPEKIINSILKIKEILDNSIIEFRNCSKSTEKLFFIEPINYFLATLRKIIVEDLFYNIDSIKNDNTLTREKIIFMANFIKLLLKWEMYSEAMIQIRELLIDLHLLAKGQILYYDDKEKRERIFWEDSLKRNEIAERLDKLTKNIIDTRNKIAHAGRGTDDFKKENLKKLLLSYVREIEELSNNIELFEKKEATLKRKVYLLNSIIIPLSKDSETGNFDIEKITKEKFYNFLKNALNEQTLDSAIGHDSIKHFIKEQFDLDIPLERKEIYFAPGEEAIVIKLEKRPEEGKIYTKEEMDYMEENNLIGYYYIKRKF
>NC_016751.1|WP_014295923.1|404945_406082_-|CRISPR-associated-protein
MYSNIVLTGGKSILGKFNLLGKFIEDNNIEHVKNLKSEDVEKWIEKVKVAFQNSKSDPKKVSVEYSLVHTLKEMNKLANNPDISIIHTNTKEGIISAKLNEYIFRKDFNANVILKGVDFDINDRIKLNKQYGEFMDILVTELQKGNIYNTFFSPTPGYKVMSYLGYVAGSFYGYKMGYLYEEGSVFQEVPPIPIKFDIEESIDYLYLIKEIQESEIKYNSLSKMEQEFIDNHTYFFDTIDGVVVLNAFGLFLFKNILTTEIFISDELKEMWDKLDNDKRKFVKTQIFELIRKIKLFKSNNNSYKGELMHNKSWEGKRFNKPYLYKSITGNIFRAVWDTDENKLNLYYIWLDHDKYEREYEKIMQKYQDYKCKNLLELI
>NC_016751.1|WP_014295924.1|406074_406896_-|CRISPR-associated-endoribonuclease-Cas6
MIEGDTIFYSIVIELKALESGVIPTFPGKKIHGLFFNILKDVDKEISYKLHEDKNYKPFTVSSFLGKKIDEPVTILKGKRYYIRMTFLEEKIFILFTTKIFKNKIFKEKINIEDISFSIIRIIFDKEHSKWANLLTIDDLLKENYDNKISLIFITPTLFKTGDKHLRYPDPEKIFNSLLIKFNKYSPYKLNEKVKEKFNTIKIIQRKTHLKYIYFPNFYLQGFTGNVVFEIPEDNYELKKTANILSDFAFYAGVGYKTTMGLGQTRREEPVNV
>NC_016751.1|WP_148265128.1|406882_407641_-|type-III-B-CRISPR-module-RAMP-protein-Cmr6
MNLKYYTNYKPENLKNASLYYDKFVYHEANPEDLKKIKDDYKDILINLDKNIIKKNIEIIKNIRIQMINKIKKHYNVKTYIVKNKTPFLIGAGIPSIDEIGFYWSRNYGLPIIPGTSIKGAFRKYIESNNDLKSIIDVVFGNAEKKGYIDFLDAIPINTIKLNIDYQTPHFQEYYMNNQPPNDVYNPIPLNYLNVSNGTFRIDLLISADSNEVINIINIHFKYFLEYFGIGAKTSMGYGRFKIQELSNFDRR
>NC_016751.1|WP_014295926.1|407637_407991_-|type-III-B-CRISPR-module-associated-protein-Cmr5
MKRENSTKLLAKKFVIQKINKKYKDDYRSLIKGLGSMIIQNGLYGTLVFLKAKNKDHHKAVFNDIEQYLKEKGLFKGEDLLTFLENTEELSTIQEKVLEFTNWYRRYVDIFIQTGGE

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Crispr_ID: NC_016751_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016751_4

414191-414612

TypeIII

Consensus_repeat	Method
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	PILER-CR
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	CRISPRCasFinder
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	CRT

5 spacers

cmr1gr7,cas10,cmr3gr5,cmr4gr7,cmr5gr11,cmr6gr7,cas6,csm6,csx1

The CRISPR arrays of NC_016751_4

>merge|NC_016751|4|414191-414612|PILER-CR,CRISPRCasFinder,CRT
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAACTTTTTCGTCAAAACTCCCATCATATAAACTATTAATTGATTCATCCGAATATCACTACTCTCTGAAAGAGATAGAAACTGGTAATCTTCTGGGATGACAACGTCATCCCATATAAAAATATCCGAATATCACTACTCTCTGAAAGAGATAGAAACACCTCACTGATTTGAAACTTTTTATCAAAACTTCCATCGTAATCCGAATATCACTACTCTCTGAAAGAGATAGAAACGGACGTGTAATCCCCTCGTTAAAATACTTTTCTACTTCTTTATCCGAATATCACTACTCTCTGAAAGAGATAGAAACTCCGATAAATCTTTTCTAATTGTATTCTGTAATTTTTTATTATCCGAATATCACCACTCTCTAAAAGAGACAAAAAA

>NC_016751|4|4|414191-414535|PILER-CR
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	TTTTTCGTCAAAACTCCCATCATATAAACTATTAATTGATTC
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	TGGTAATCTTCTGGGATGACAACGTCATCCCATATAAAAAT
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	ACCTCACTGATTTGAAACTTTTTATCAAAACTTCCATCGTA
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	GGACGTGTAATCCCCTCGTTAAAATACTTTTCTACTTCTTT
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC

>NC_016751|4|4|414191-414612|CRISPRCasFinder
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	TTTTTCGTCAAAACTCCCATCATATAAACTATTAATTGATTC
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	TGGTAATCTTCTGGGATGACAACGTCATCCCATATAAAAAT
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	ACCTCACTGATTTGAAACTTTTTATCAAAACTTCCATCGTA
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	GGACGTGTAATCCCCTCGTTAAAATACTTTTCTACTTCTTT
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	TCCGATAAATCTTTTCTAATTGTATTCTGTAATTTTTTATT
ATCCGAATATCACCACTCTCTAAAAGAGACAAAAAA

>NC_016751|4|4|414191-414612|CRT
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	TTTTTCGTCAAAACTCCCATCATATAAACTATTAATTGATTC
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	TGGTAATCTTCTGGGATGACAACGTCATCCCATATAAAAAT
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	ACCTCACTGATTTGAAACTTTTTATCAAAACTTCCATCGTA
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	GGACGTGTAATCCCCTCGTTAAAATACTTTTCTACTTCTTT
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	TCCGATAAATCTTTTCTAATTGTATTCTGTAATTTTTTATT
ATCCGAATATCACCACTCTCTAAAAGAGACAAAAAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_016751.1\|WP_014295932.1\|416375_418568_-\|DUF4230-domain-containing-protein	unknown	unknown	gnl\|CDD\|379417
NC_016751.1\|WP_014295927.1\|408000_408828_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr4	cmr4gr7	cd09682_cmr4gr7_CAS-III-B	gnl\|CDD\|274210
NC_016751.1\|WP_014295936.1\|423268_424153_+\|hypothetical-protein	unknown	unknown	unknown
NC_016751.1\|WP_014295929.1\|409805_412166_-\|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	cas10	cd09679_cas10_CAS-III	gnl\|CDD\|187810
NC_016751.1\|WP_014295931.1\|414675_416343_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|313108
NC_016751.1\|WP_014295922.1\|403243_404935_-\|DUF1874-domain-containing-protein	csx1	pfam09455_csx1_CAS-III	gnl\|CDD\|378186
NC_016751.1\|WP_014295939.1\|427313_427985_+\|Crp/Fnr-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223736
NC_016751.1\|WP_014295924.1\|406074_406896_-\|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	gnl\|CDD\|273848
NC_016751.1\|WP_014295930.1\|412162_413416_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr1	cmr1gr7	COG1367_cmr1gr7_CAS-III-B	gnl\|CDD\|224286
NC_016751.1\|WP_014295941.1\|429151_430282_-\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|277318
NC_016751.1\|WP_148265128.1\|406882_407641_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr6	cmr6gr7	COG1604_cmr6gr7_CAS-III-B	gnl\|CDD\|224520
NC_016751.1\|WP_014295940.1\|427981_428980_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_016751.1\|WP_014295934.1\|419451_421776_-\|trypsin-like-peptidase-domain-containing-protein	unknown	unknown	gnl\|CDD\|223343
NC_016751.1\|WP_014295923.1\|404945_406082_-\|CRISPR-associated-protein	csm6	cd09742_csm6_CAS-III-A:CAS-III-D	gnl\|CDD\|187873
NC_016751.1\|WP_014295928.1\|408841_409819_-\|type-III-B-CRISPR-module-associated-protein-Cmr3	cmr3gr5	cd09748_cmr3gr5_CAS-III-B	gnl\|CDD\|187879
NC_016751.1\|WP_156865381.1\|402827_402983_-\|hypothetical-protein	unknown	unknown	unknown
NC_016751.1\|WP_014295937.1\|424180_424693_+\|DUF1232-domain-containing-protein	unknown	unknown	gnl\|CDD\|225876
NC_016751.1\|WP_014295926.1\|407637_407991_-\|type-III-B-CRISPR-module-associated-protein-Cmr5	cmr5gr11	pfam09701_cmr5gr11_CAS-III-B	gnl\|CDD\|378242
NC_016751.1\|WP_014295933.1\|418564_419431_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225628
NC_016751.1\|WP_014295935.1\|421907_423257_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_016751.1\|WP_014295927.1\|408000_408828_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr4	gnl\|CDD\|274210	TIGR02580, putative_CRISPR-associated_protein, CRISPR type III-B/RAMP module RAMP protein Cmr4. This model represents a CRISPR-associated protein from the family that includes TM1792 of Thermotoga maritima. This family is part of the broad RAMP superfamily (pfam03787) collection of CRISPR-associated proteins. It is the fourth of a recurring set of six proteins, four of are in the RAMP superfamily, that we designate the CRISPR RAMP module.	1.02789e-68
NC_016751.1\|WP_014295929.1\|409805_412166_-\|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	gnl\|CDD\|187810	cd09679, Cas10_III, CRISPR/Cas system-associated protein Cas10. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Multidomain protein with permuted HD nuclease domain, palm domain and Zn-ribbon; MTH326-like has inactivated polymerase catalytic domain; alr1562 and slr7011 - predicted only on the basis of size, presence of HD domain, and location with RAMPs in one operon; signature gene for type III; also known as Crm2 family.	6.32108e-85
NC_016751.1\|WP_014295931.1\|414675_416343_+\|AAA-family-ATPase	gnl\|CDD\|313108	pfam09820, AAA-ATPase_like, Predicted AAA-ATPase. This family contains many hypothetical bacterial proteins. This family was previously the N-terminal part of the Pfam DUF1703 (pfam08011) family before it was split into two. This region is predicted to be an AAA-ATPase domain.	4.45105e-64
NC_016751.1\|WP_014295922.1\|403243_404935_-\|DUF1874-domain-containing-protein	gnl\|CDD\|378186	pfam09455, Cas_DxTHG, CRISPR-associated (Cas) DxTHG family. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. The family describes Cas proteins of about 400 residues that include the motif [VIL]-D-x-[ST]-H-[GS]. The CRISPR and associated proteins are thought to be involved in the evolution of host resistance. The exact molecular function of this family is currently unknown.	1.79529e-33
NC_016751.1\|WP_014295933.1\|418564_419431_-\|hypothetical-protein	gnl\|CDD\|225628	COG3086, RseC, Positive regulator of sigma E activity [Signal transduction mechanisms].	0.00386325
NC_016751.1\|WP_014295924.1\|406074_406896_-\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	8.27481e-14
NC_016751.1\|WP_014295930.1\|412162_413416_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr1	gnl\|CDD\|224286	COG1367, COG1367, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	4.35042e-25
NC_016751.1\|WP_014295939.1\|427313_427985_+\|Crp/Fnr-family-transcriptional-regulator	gnl\|CDD\|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	7.80557e-24
NC_016751.1\|WP_148265128.1\|406882_407641_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr6	gnl\|CDD\|224520	COG1604, COG1604, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	1.54549e-41
NC_016751.1\|WP_014295940.1\|427981_428980_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	6.90512e-121
NC_016751.1\|WP_014295934.1\|419451_421776_-\|trypsin-like-peptidase-domain-containing-protein	gnl\|CDD\|223343	COG0265, DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones].	3.98357e-32
NC_016751.1\|WP_014295923.1\|404945_406082_-\|CRISPR-associated-protein	gnl\|CDD\|187873	cd09742, Csm6_III-A, CRISPR/Cas system-associated protein Csm6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Protein of this family often fused to HTH domain; loosely associated with CRISPR/Cas systems; also known as APE2256 family.	1.6829e-10
NC_016751.1\|WP_014295932.1\|416375_418568_-\|DUF4230-domain-containing-protein	gnl\|CDD\|379417	pfam14014, DUF4230, Protein of unknown function (DUF4230). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 203 and 228 amino acids in length.	0.000121753
NC_016751.1\|WP_014295941.1\|429151_430282_-\|metallophosphoesterase	gnl\|CDD\|277318	cd00839, MPP_PAPs, purple acid phosphatases of the metallophosphatase superfamily, metallophosphatase domain. Purple acid phosphatases (PAPs) belong to a diverse family of binuclear metallohydrolases that have been identified and characterized in plants, animals, and fungi. PAPs contain a binuclear metal center and their characteristic pink or purple color derives from a charge-transfer transition between a tyrosine residue and a chromophoric ferric ion within the binuclear center. PAPs catalyze the hydrolysis of a wide range of activated phosphoric acid mono- and di-esters and anhydrides. PAPs are distinguished from the other phosphatases by their insensitivity to L-(+) tartrate inhibition and are therefore also known as tartrate resistant acid phosphatases (TRAPs). While only a few copies of PAP-like genes are present in mammalian and fungal genomes, multiple copies are present in plant genomes. PAPs belong to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	1.1417e-26
NC_016751.1\|WP_014295937.1\|424180_424693_+\|DUF1232-domain-containing-protein	gnl\|CDD\|225876	COG3339, COG3339, Uncharacterized conserved protein [Function unknown].	1.1615e-07
NC_016751.1\|WP_014295926.1\|407637_407991_-\|type-III-B-CRISPR-module-associated-protein-Cmr5	gnl\|CDD\|378242	pfam09701, Cas_Cmr5, CRISPR-associated protein (Cas_Cmr5). CRISPR is a term for Clustered, Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family, represented by TM1791.1 of Thermotoga maritima, is found in both archaeal and bacterial species.	3.63055e-23
NC_016751.1\|WP_014295928.1\|408841_409819_-\|type-III-B-CRISPR-module-associated-protein-Cmr3	gnl\|CDD\|187879	cd09748, Cmr3_III-B, CRISPR/Cas system-associated RAMP superfamily protein Cmr3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; This protein is a subunit of Cmr complex.	1.55475e-57

>NC_016751.1|WP_014295930.1|412162_413416_-|type-III-B-CRISPR-module-RAMP-protein-Cmr1
MNILEFELLTTSPMFASRDGKTFSLTPQSVRGVMRFWFRAVVPRVIDIHYYNGERKPYIGLKKAEELIFGSTERKSSFDVIVDLISPTNITNNHDYFTFARINKRNRKINYIYGIYGVEEREFLKEKSKLNITFIIKKQPDKLLNIIINLMNLISLVSGFGAKTRKGFGSFKIELIKTNKENSSEIKNSVKNILNELDENLKRYFSSISDTHFKYSQTEFLDIPEFPVLLSDPKTYRVVSTKKSPIKNFSDIYKKLYATEMQESKKGVYIKVKKKLRTLNNTDSFTNALREVEASSKNTIESNIIFYQALMGLPINYKYNITSKKLRNYKGNEYTLTNGERKASPFFFSFHLNEKNEYYVRILMITSKISLNNKIYFEGRRNKLITESPESFEIYNQAMDIFKKEVEKKLTNKGEKK
>NC_016751.1|WP_014295929.1|409805_412166_-|type-III-B-CRISPR-associated-protein-Cas10/Cmr2
MNWEKKIIALLHDPIEKALNLEKHENIANRRLNKLGTYLKDDYKNPDYLSSAADRILFPKEKEHFSKRISINIYHYPEYLHPLNGEKLEDYFKNDFKQKIDKLNSEKITDKLEKLEDFKKTYYKTWWELPEQTELSFMLPGDTRIPSHSIIDHLDSASAMSVSNKMSLLLVSIGPVQEFIAAARKTIDLKVGSYMLSYLTFQGIKVIGEEYGYDNVIFPYMRGNYFVKKEFEKIGIFVETSADPGVASLPNIFTAIVPTKDLEKIKSKIKKAIKDEMSNISQFIKIYIEDLIQSEKKYKETIFQKLEAFKNWDKQISQFPIIITVDQEINNIEKYIEKHYIYTEDENIKKLYQKMKQLESTYQMKDIAFYGMYSELLGIKSSLRKTTRDFIQLFEDDVVNGDDLSGANKAVIEIIDKDEKKERLSALSAIKRLFVEYLNEIGYKEAYEKLKYVKSTEEIAGKYKLAVLLMDGDNMGKWISGTLAPSFKKRLHSKVIKELEREDKEYTKLLENINLVTPSYQRMISRTLNNFSNFVPKVVEEFDGLLIYAGGDDVLALFPSNKVFDAANKLRKVYSGIGEEKVGEYVFKNGWCYKKEKNLEYPVFNMMGKQATMSAGIVISKHNFNLKLALNKAREMEKLAKSNEEKSGRKKDSFAIATIRRSGQINISKSFWELNRFDILLKGLEFIKDFEKEKSIKNIILRLKSEYINYCFDEFGNEILTIEDFKNNIIPFLEKRMEIKKDKLKNSFVKLITLNERFLTGNKLMEYFNTLENIEYARRENIYEKN
>NC_016751.1|WP_014295928.1|408841_409819_-|type-III-B-CRISPR-module-associated-protein-Cmr3
MKKIKTLFIKPVDWVGFRKSKTFSHAEETIFPNPKTFYGAIMTAYMRKKNLTQEEIEQIIKDKKLKIIGPFLTDSESNIYFRMPAIIKQNDITKEFYKGEIDETFTFNLNGKELYGIKYKSMRNLKEPEKTYISLNELEELKKGNLKISNDNSEIYFKEEKIGIALENRKAMEGMLYSYSYFRFIDDAGFAFFIERDELNILNEIEIITLGTKGKMAKIEIKEIETSIFDPIIDTQKGLLLLTPAYFEDGVKPIFDSNIIAIANYKPETIGYWDLKNNHPGEQFKVVPSGSVYVIKGDFEKENYKINFTDKYDEYNFGKYIEIKI
>NC_016751.1|WP_014295927.1|408000_408828_-|type-III-B-CRISPR-module-RAMP-protein-Cmr4
MSGKVGFLYAVTQIHAGKGMDVGVVDQPIQREVHTGFPIIAGIKGAIRNELSFNKEEEIFGSKPGNNNKESKPGNITFSEAKILFFPLRSINRGLVWITCPMVLSRLKTAFEISGNTEMASKINKFLKTIKNKKEYSTFKSTVVNVEEYAIETEESNELKELMKELKKVSPDEYLQKVLEENVIVLKDEDFSFFVRNATEVLPRIRINPDTGTVAEGALWYEEYLPQDTVMFFLIKSLKNSEELLNEVEKNLDKEYINIGGKASVGKGFSYIKLM
>NC_016751.1|WP_014295926.1|407637_407991_-|type-III-B-CRISPR-module-associated-protein-Cmr5
MKRENSTKLLAKKFVIQKINKKYKDDYRSLIKGLGSMIIQNGLYGTLVFLKAKNKDHHKAVFNDIEQYLKEKGLFKGEDLLTFLENTEELSTIQEKVLEFTNWYRRYVDIFIQTGGE
>NC_016751.1|WP_148265128.1|406882_407641_-|type-III-B-CRISPR-module-RAMP-protein-Cmr6
MNLKYYTNYKPENLKNASLYYDKFVYHEANPEDLKKIKDDYKDILINLDKNIIKKNIEIIKNIRIQMINKIKKHYNVKTYIVKNKTPFLIGAGIPSIDEIGFYWSRNYGLPIIPGTSIKGAFRKYIESNNDLKSIIDVVFGNAEKKGYIDFLDAIPINTIKLNIDYQTPHFQEYYMNNQPPNDVYNPIPLNYLNVSNGTFRIDLLISADSNEVINIINIHFKYFLEYFGIGAKTSMGYGRFKIQELSNFDRR
>NC_016751.1|WP_014295924.1|406074_406896_-|CRISPR-associated-endoribonuclease-Cas6
MIEGDTIFYSIVIELKALESGVIPTFPGKKIHGLFFNILKDVDKEISYKLHEDKNYKPFTVSSFLGKKIDEPVTILKGKRYYIRMTFLEEKIFILFTTKIFKNKIFKEKINIEDISFSIIRIIFDKEHSKWANLLTIDDLLKENYDNKISLIFITPTLFKTGDKHLRYPDPEKIFNSLLIKFNKYSPYKLNEKVKEKFNTIKIIQRKTHLKYIYFPNFYLQGFTGNVVFEIPEDNYELKKTANILSDFAFYAGVGYKTTMGLGQTRREEPVNV
>NC_016751.1|WP_014295923.1|404945_406082_-|CRISPR-associated-protein
MYSNIVLTGGKSILGKFNLLGKFIEDNNIEHVKNLKSEDVEKWIEKVKVAFQNSKSDPKKVSVEYSLVHTLKEMNKLANNPDISIIHTNTKEGIISAKLNEYIFRKDFNANVILKGVDFDINDRIKLNKQYGEFMDILVTELQKGNIYNTFFSPTPGYKVMSYLGYVAGSFYGYKMGYLYEEGSVFQEVPPIPIKFDIEESIDYLYLIKEIQESEIKYNSLSKMEQEFIDNHTYFFDTIDGVVVLNAFGLFLFKNILTTEIFISDELKEMWDKLDNDKRKFVKTQIFELIRKIKLFKSNNNSYKGELMHNKSWEGKRFNKPYLYKSITGNIFRAVWDTDENKLNLYYIWLDHDKYEREYEKIMQKYQDYKCKNLLELI
>NC_016751.1|WP_014295922.1|403243_404935_-|DUF1874-domain-containing-protein
MEKILLLSFLGKGRYNESLYYRLEAENKKAKSYLSPLANAYLEKERGNDVEIKFFITKEVKENFLENPNSEHGQNINNEINNLHQKGISVTFENIPEGRNYNELEEIISIIKKSISEFSEKEIIFDLTHGLRHISTFTTGVIFYLKNLQQDFEEKNIILYYGAYDIRKEFKNKPPEVPILNISSTLELSNLTLALEEFKEYGITKRIEKALRNIQKLVATNKLCNVNKLKFSSLSTELSNFNNIIKIPASPEKIINSILKIKEILDNSIIEFRNCSKSTEKLFFIEPINYFLATLRKIIVEDLFYNIDSIKNDNTLTREKIIFMANFIKLLLKWEMYSEAMIQIRELLIDLHLLAKGQILYYDDKEKRERIFWEDSLKRNEIAERLDKLTKNIIDTRNKIAHAGRGTDDFKKENLKKLLLSYVREIEELSNNIELFEKKEATLKRKVYLLNSIIIPLSKDSETGNFDIEKITKEKFYNFLKNALNEQTLDSAIGHDSIKHFIKEQFDLDIPLERKEIYFAPGEEAIVIKLEKRPEEGKIYTKEEMDYMEENNLIGYYYIKRKF
>NC_016751.1|WP_156865381.1|402827_402983_-|hypothetical-protein
MKSYKDLMQELLEDEKFREIHFKKEALHHFLDEIVKDEKKKGKFIEALNLL
>NC_016751.1|WP_014295931.1|414675_416343_+|AAA-family-ATPase
MKELKSLPLGESNFKTIMENNMYFIDKSMLIKDILSAGRVILITRPRRFGKTLNMSMLEHFFSMKKNSESLFKDLKIWNEKKIIEKYLNKYPVIFISFKGLKKKKYEDMKNGIRELISKLYTKYVYLLNTDKITQWDKKRIIGILDKTAEDAVFEDGIKNLTEYLYIYHGKKVILLIDEYDTPIQQSYLNGYYDELIDFIGNILGNALKDNEYLEKAVLTGITRVAKESIFTGVNNLQISTVLSRLFNDKFGMTKEELHEALKYYGMEYEEEKIIEWYNGFNFGGFEIYNPYSIMNLIFEKEIKNYWINTSGNKLIKDLIAKGSAEIKSKIYDLIEGETVTTTINENLVYGDLNVNVEESVWTLFLFTGYLTWIDKIGEGNSAEYRLKITNKEALDFFKKTVVNILEDSGFKYKTLLKDLIEENYEEFKENFKELVENTISYFDVSGKEPERFYHGLILGLSVGLQKEYIIKSNRESGYGRADLILIPKKRSNPGIIFEFKKYYKKDGDLKSSAEKGMKQIEEKNYETEIKSHGIERIIKVAIAFDKKEVEIVIK
>NC_016751.1|WP_014295932.1|416375_418568_-|DUF4230-domain-containing-protein
MKKMIIRILTLALIIGIAFLVSRYNIISNFFAKSKEVSVQIPSLNIEAIRDLAQLRVFSYNMDFLFIAKDENNNYYVAIYPYTVEAGIDLNKIKSEEKVYSKGVIYFPSPEIFYYGESFDKKPIIVTDQIKIDSSYYKDNIKEGFKMYSRDIAINKGIYEKTEKALKEYLKKFVPEEYDLKFSEPDNNFTKINAERFQAYFKLTNELYRKYKFSDENGKYFAEFLNKEDPEIKFTFNFSQEYKKDHKTFFNDVESKFKGELCYKLVNPDNPFDYNYSFKINRNKNTLIGFILNGGDLINFKFNTQNEEDFKKYTSDFIYYMFAYRNSQNKNYTEVGKYKDFINYLYKSQIAIDEEKINTLENLGENILSLQRDVYSEYGNLFINLEKLIEKNIDTSENINDYNLKLLAKAYYYINNKDKRIIELIDDLKTWFEKNENIENAFEPYLMQEYYNWNINEKISLLKDKVMTYLMINYKNYLKNDEIEKYKREIINEGIYYSNVWNNIINSDIERKEYLKRIYLNIVKNQKLEHYLYYDKDKKLVRIKDFNDPDFYLSDIYYDFQVKDKYNNIILDSDSLANAFVEMYEKFSEKEKENFKSLIKDNFDDEYYFFSDVNSKKFFKNNFIIVLTRNAFNLPKNAFKVYTVFVFGKNGLLLFETSKKIFGDGFKLKYQKFIEYSELPEKLEHKNASIKAILDVLNDTESNNLTEEICENLKYLIRFILRNKVNVFVL
>NC_016751.1|WP_014295933.1|418564_419431_-|hypothetical-protein
MDEQDKVKKKNGMLKRFAVILFYIGIFILFVFIFNYFFPVENEVSAPKKSYFDNIEYIVFKEIQFNNYIVYKDNNQNKARVYYIKGRAEIKFNVEDLKKRIESDSVTGKEIVYISIPQKDMLKIDVEIENSKEIDTFPIEVKSNNSNLMDITEKFSPVVGTVLGAWIGSKLTNISILKNFKAINIVGTLGGAVGGYLLTKHFVRKLEKSSSQSSNTVNDLSLGLDEEIKAKAKDLIALEFLYGNDNEFKKDIIEYYKSEFLKAVKPLYSIQDENVEVVWDNSLLEVIQ
>NC_016751.1|WP_014295934.1|419451_421776_-|trypsin-like-peptidase-domain-containing-protein
MKKSFFLLFIVLLIFSIFSFGDIKILNISMEDRDELFYYAPIVTNNYIILASPGTPDKDYNDAGIYLLDKENLEILDVFKTYSPVSIVSGECFYPGYFSTYYAYYDNTLISFYVSDSEKISVEWKKSFEYKDIEITNDFDNDFIIKENKLNARKNDIIIKINDEYLYNYSDMAKYLENYSEDVATLHLLRNNSNISYVYKTNIVTKPDYIISGVIYRDEFDFSDNLFIQTEKYIYQLDYEGNIINRYYAEKKSHKLPPTFSDLNQDGKIEVVFFEDNYIKILDNGNLIKIDFDYWYQDEEDIFAPISTVYYADVDNDYYPEGVFVDKNFTINYIEYDPTTKSYYISYSELPNKGNYKYPLVSGNVVYDFNFTGDLLTLITYNKEIYMLSSDEKIISKKILKFPIISRPYIYWKNGWFIVLTQYDFDNEKTFLTKLKYKDEKFEIIDTYEYNGFYLLEGYIPYNDNIYALLCSSENTILQYIEKDGTEIFEAYKTYMSNNNNFIDYIQTFKKHDLKNKLLIAERGEEIISPEEIAKKMESVVRINNYVYSSYEELEGSGSGFIIAEDDFYYYIATNAHVVSTIGEDITKDISYYGLSITFFNGETVSPEEVFINTTFKDIAILSISKFYLDNTYPVLPLGLYSHTIGTKVYALGNPEGLDFTFTQGIISALRFARINEFYNINNNKFFELIQTDAAINHGNSGGPLIDKYGNVIGINSLGGDKNITEGLNFAISANDLYYEIKKDNFIKLFYDSRLPNDWLFKTLKNKFSKYYNY
>NC_016751.1|WP_014295935.1|421907_423257_+|hypothetical-protein
MDEKIIFSILNHENDIIYKKYLNNEFLFGESIETTITPLHAAIISDNIEVIKLMEKSGYNIVYALLNNNDILNPYILAKRLDREEIVEYFDEILEQNLNTDLKNTENFKYIEIEKVFEDILKDAENKQKIQEFLEKFLKHPKNLLLETNIAKRIFCEIPNEELVFFIKKIIDVLTDEYCSMFLYEFLDPKCKLASVYALIRIKESQNIAVYYNEKYINRLIDIYDIFMLNDDEDKITYLETINRFYIEELSEDIKDLFFETQNDKLKYITYKILLKYELEELFEITKEAMKSNYLPLKELATLICILKYENNCKKQDNIKFENLREEDYIAISLFDTPYVEDIIYKKFSTFSYDTKLNIIHNLIIISSKRRYNMLLDIYKFEKNPEIKAEIIYQFIIREIYTPEILKVFIEDFIKNLDEYNSYDDNEDFNIFSALGHYFANILMKKELF
>NC_016751.1|WP_014295936.1|423268_424153_+|hypothetical-protein
MKKILLFFLLSFLTVFVYAQILLSTEGKKILEEELNRFNIEVINEIDNTTEKIYNKIADYEKYSKIFVEDITDLGSTSKSIYYMSKDSLLKLIKRNSNSYENYIKKMFEHHFFNEEKIKKIIVDEINIFNIKINEKLYTFIENLDKKLSMEDKKILENDDDFKSFVNAFDVNGIFKNNNEIFSEQIINLVSTHQNSILKKKLFSATLKSGSIVGSFWISLSTQNPIFVATSIFYTIILTLNSEKNNIKKEELAVEISSQIEKYADNISNIVKKLLSQTIDTEINKIKKSFNLLY
>NC_016751.1|WP_014295937.1|424180_424693_+|DUF1232-domain-containing-protein
MPNNNFKDFENEVNSYENKVEIESDSFYKKLRNKIKKWAGKNKDNKILEYILLAPDLFYFFLTVLKDKDVYVDYKLKITGYLAYFISPIDIMPEMVLGPAGYLDDVLMGLLFLRTLLKELPYEYVEEKWPGDKEVLKNVSVMIDNIQAIIDSKIFRSVMSYFSKNIEKKK
>NC_016751.1|WP_014295939.1|427313_427985_+|Crp/Fnr-family-transcriptional-regulator
MQQIFEQISKTPIFKSLKITEIEELISSEKMIIKSYEKDEIIRFRGEKVNEVMILLSGQVKAEMSDTQGKIIEIEEIKAPNLLAVGATFSKNSIIPVDIIAIEKSTVAFINKDEVLNLCMHNKDFLQELIEYLGTKFVFISQRLWFITLNNIKDKILFHIKGKLKDSSDDYVILEYSVEQLSHLFGVTRPSLSRAFSKLEEEGIIKKEGNKIYILNKNIFKDF
>NC_016751.1|WP_014295940.1|427981_428980_-|LacI-family-DNA-binding-transcriptional-regulator
MKRINIKDVAKEAGVSISTVSRVINKSAPVKEELRKKVEEAIKKLEYKPSIVARSLRKGKAKTIGLVIPDITDPYFPHIVKGIEDYLKKEDYTLLLSNSGQDLEQETKIIETFESNHIDGVIFIGSGLTNPYLKHLKERGIKVVYLDRILKGIDVSYVVSDNKQGMHDLLQYLYDTNHRSFHFVNGNENTFSAQVRYEAFAEFMEKNNIKSYKHIYSCFSYDAGYQYGKEIDLKKLPDVIMGGNDLIAYGLMDALDERGVKIPDDVSITGFNDIPFSRHYKPSLTTVRQPIYKMGYTAANLIIQIINSDGPVFKGIVLKTELIVRNSTRRRD
>NC_016751.1|WP_014295941.1|429151_430282_-|metallophosphoesterase
MKKYILLFILLFSALYLFSKSLFLWPPYITYNGKDLFLNFKTNGIIKGLSIHIIDKNLNEVYSIKLQENELYHIPINIDYVNENFEYIIKQNSKVIYKNTFNEFNPLKKDFTFVVYGDTRYYDKLHRMIVDKIIEEKPDFVINVGDMVENGENINYWTNFFNTIKGLNIPYFPIPGNHEKNSKYYYDAFILPEGGGFQNKQWYSFKYGNLNFILLDSIIINNSELFKQETIWLEQTLKNNKNYINIIIFHYPFWNNSIYAWRRDNKILEKKWRPIFEKYNVKLVFNGHVHAYERFKLNDITYITTGGGGAPFDPGHKEKLNPYTQKIHYGYLEYVLLKVKAGKITVITKAVGKSDNYKMNNVKSLDMVLDFFEIDK

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Crispr_ID: NC_016751_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016751_5

425317-426729

TypeIII

Consensus_repeat	Method
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	PILER-CR
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	CRISPRCasFinder
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	CRT

18 spacers

cmr1gr7,cas10,cmr3gr5

The CRISPR arrays of NC_016751_5

>merge|NC_016751|5|425317-426729|PILER-CR,CRISPRCasFinder,CRT
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAACATAAATAAACTATCTCGTAATTTTTATTGTCTGAAAGTATATCCGAATATAACTACTCTCTGAAAGAGATAGAAACTTTAGCTGAATAATAATAATTCTTTTCAATGTTGCAAATCCGAATATAACTACTCTCTGAAAGAGATAGAAACACAAATAGAAAATTTTTCATCGAATGAACCATCGTAGAGGCTATCCGAATATAACTACTCTCTGAAAGAGATAGAAACAAATACCTCTAAAACCTTTTTTATTTACTTTTTTTATTAAATCCGAATATAACTACTCTCTGAAAGAGATAGAAACGAGGTCATCGAAATACTCGGACTCTATGTCTCCAATAGAGGAATCCGAATATAACTACTCTCTGAAAGAGATAGAAACTCTTCTTCTTTTTCTACCCACCCGAATATTCTAAGGTGGGCATCCGAATATAACTACTCTCTGAAAGAGATAGAAACTTCACCTCCTCTGGAGTTGGCTTTCTATATTCAATGATTCCATCCGAATATAACTACTCTCTGAAAGAGATAGAAACTTCGATCCACCATCTAAGCTGTCATCTCCTTTCTCTAAGGAAATCCGAATATAACTACTCTCTGAAAGAGATAGAAACGCAACTTTTTTAATCATTGTTCTGGGTTTTGTTTTCCATAATCCGAATATAACTACTCTCTGAAAGAGATAGAAACAATTTTTCAATCAATTTTTTTACTCTTTCTCTTTCTAACAATCCGAATATAACTACTCTCTGAAAGAGATAGAAACGGGTATCATACATCCCCAATCTGAGAAGAATTGGGGATATAATCCGAATATAACTACTCTCTGAAAGAGATAGAAACATTGTTACAACATCAGCAATAGTGAAATGATACTCTTCTTATCCGAATATAACTACTCTCTGAAAGAGATAGAAACACTTTTTTCATTATATTTAAAAATTTTCTAATTTTTTTCAATCCGAATATAACTACTCTCTGAAAGAGATAGAAACTAATAATGGTTGGAAAATCGAGGAATGACAATTCATCATAATCCGAATATAACTGCTCTCTGAAAGAGATAGAAACTGCGGTTTAAACTCTCTCCAATTTCCAATAGGAACTACCTCATCCGAATATAACTGCTCTCTGAAAGAGATAGAAACAAAATAATCAAATGCTCCTTCTGCAATCAAAAAATATTCTTATCCGAATATCACTACTCTCTGAAAGAGATAGAAACCAAGTTCGTCTGCTTCTGGTGATAAATCGATTCTGTCTATAATCCGAATATCACTACTCTCTGAAAGAGATAGAAACTTCATTTCCTCGATTTTTTCTTCCTTCATTGATTCAGGTATTCCGAATATAACTGCTCTCTGAAAGAGATAGAAAC

>NC_016751|5|5|425317-426729|PILER-CR
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	ATAAATAAACTATCTCGTAATTTTTATTGTCTGAAAGTAT
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	TTTAGCTGAATAATAATAATTCTTTTCAATGTTGCAA
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	ACAAATAGAAAATTTTTCATCGAATGAACCATCGTAGAGGCT
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	AAATACCTCTAAAACCTTTTTTATTTACTTTTTTTATTAA
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	GAGGTCATCGAAATACTCGGACTCTATGTCTCCAATAGAGGA
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	TCTTCTTCTTTTTCTACCCACCCGAATATTCTAAGGTGGGC
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	TTCACCTCCTCTGGAGTTGGCTTTCTATATTCAATGATTCC
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	TTCGATCCACCATCTAAGCTGTCATCTCCTTTCTCTAAGGAA
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	GCAACTTTTTTAATCATTGTTCTGGGTTTTGTTTTCCATA
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	AATTTTTCAATCAATTTTTTTACTCTTTCTCTTTCTAACA
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	GGGTATCATACATCCCCAATCTGAGAAGAATTGGGGATATA
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	ATTGTTACAACATCAGCAATAGTGAAATGATACTCTTCTT
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	ACTTTTTTCATTATATTTAAAAATTTTCTAATTTTTTTCA
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	TAATAATGGTTGGAAAATCGAGGAATGACAATTCATCATA
ATCCGAATATAACTGCTCTCTGAAAGAGATAGAAAC	TGCGGTTTAAACTCTCTCCAATTTCCAATAGGAACTACCTC
ATCCGAATATAACTGCTCTCTGAAAGAGATAGAAAC	AAAATAATCAAATGCTCCTTCTGCAATCAAAAAATATTCTT
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	CAAGTTCGTCTGCTTCTGGTGATAAATCGATTCTGTCTATA
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	TTCATTTCCTCGATTTTTTCTTCCTTCATTGATTCAGGTA
TTCCGAATATAACTGCTCTCTGAAAGAGATAGAAAC

>NC_016751|5|5|425317-426729|CRISPRCasFinder
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	ATAAATAAACTATCTCGTAATTTTTATTGTCTGAAAGTAT
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	TTTAGCTGAATAATAATAATTCTTTTCAATGTTGCAA
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	ACAAATAGAAAATTTTTCATCGAATGAACCATCGTAGAGGCT
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	AAATACCTCTAAAACCTTTTTTATTTACTTTTTTTATTAA
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	GAGGTCATCGAAATACTCGGACTCTATGTCTCCAATAGAGGA
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	TCTTCTTCTTTTTCTACCCACCCGAATATTCTAAGGTGGGC
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	TTCACCTCCTCTGGAGTTGGCTTTCTATATTCAATGATTCC
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	TTCGATCCACCATCTAAGCTGTCATCTCCTTTCTCTAAGGAA
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	GCAACTTTTTTAATCATTGTTCTGGGTTTTGTTTTCCATA
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	AATTTTTCAATCAATTTTTTTACTCTTTCTCTTTCTAACA
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	GGGTATCATACATCCCCAATCTGAGAAGAATTGGGGATATA
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	ATTGTTACAACATCAGCAATAGTGAAATGATACTCTTCTT
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	ACTTTTTTCATTATATTTAAAAATTTTCTAATTTTTTTCA
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	TAATAATGGTTGGAAAATCGAGGAATGACAATTCATCATA
ATCCGAATATAACTGCTCTCTGAAAGAGATAGAAAC	TGCGGTTTAAACTCTCTCCAATTTCCAATAGGAACTACCTC
ATCCGAATATAACTGCTCTCTGAAAGAGATAGAAAC	AAAATAATCAAATGCTCCTTCTGCAATCAAAAAATATTCTT
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	CAAGTTCGTCTGCTTCTGGTGATAAATCGATTCTGTCTATA
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	TTCATTTCCTCGATTTTTTCTTCCTTCATTGATTCAGGTA
TTCCGAATATAACTGCTCTCTGAAAGAGATAGAAAC

>NC_016751|5|5|425317-426729|CRT
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	ATAAATAAACTATCTCGTAATTTTTATTGTCTGAAAGTAT
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	TTTAGCTGAATAATAATAATTCTTTTCAATGTTGCAA
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	ACAAATAGAAAATTTTTCATCGAATGAACCATCGTAGAGGCT
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	AAATACCTCTAAAACCTTTTTTATTTACTTTTTTTATTAA
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	GAGGTCATCGAAATACTCGGACTCTATGTCTCCAATAGAGGA
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	TCTTCTTCTTTTTCTACCCACCCGAATATTCTAAGGTGGGC
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	TTCACCTCCTCTGGAGTTGGCTTTCTATATTCAATGATTCC
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	TTCGATCCACCATCTAAGCTGTCATCTCCTTTCTCTAAGGAA
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	GCAACTTTTTTAATCATTGTTCTGGGTTTTGTTTTCCATA
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	AATTTTTCAATCAATTTTTTTACTCTTTCTCTTTCTAACA
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	GGGTATCATACATCCCCAATCTGAGAAGAATTGGGGATATA
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	ATTGTTACAACATCAGCAATAGTGAAATGATACTCTTCTT
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	ACTTTTTTCATTATATTTAAAAATTTTCTAATTTTTTTCA
ATCCGAATATAACTACTCTCTGAAAGAGATAGAAAC	TAATAATGGTTGGAAAATCGAGGAATGACAATTCATCATA
ATCCGAATATAACTGCTCTCTGAAAGAGATAGAAAC	TGCGGTTTAAACTCTCTCCAATTTCCAATAGGAACTACCTC
ATCCGAATATAACTGCTCTCTGAAAGAGATAGAAAC	AAAATAATCAAATGCTCCTTCTGCAATCAAAAAATATTCTT
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	CAAGTTCGTCTGCTTCTGGTGATAAATCGATTCTGTCTATA
ATCCGAATATCACTACTCTCTGAAAGAGATAGAAAC	TTCATTTCCTCGATTTTTTCTTCCTTCATTGATTCAGGTA
TTCCGAATATAACTGCTCTCTGAAAGAGATAGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_016751.1\|WP_014295946.1\|435921_437202_+\|cyclic-nucleotide-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|237999
NC_016751.1\|WP_014295936.1\|423268_424153_+\|hypothetical-protein	unknown	unknown	unknown
NC_016751.1\|WP_014295935.1\|421907_423257_+\|hypothetical-protein	unknown	unknown	unknown
NC_016751.1\|WP_014295931.1\|414675_416343_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|313108
NC_016751.1\|WP_014295937.1\|424180_424693_+\|DUF1232-domain-containing-protein	unknown	unknown	gnl\|CDD\|225876
NC_016751.1\|WP_014295930.1\|412162_413416_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr1	cmr1gr7	COG1367_cmr1gr7_CAS-III-B	gnl\|CDD\|224286
NC_016751.1\|WP_014295933.1\|418564_419431_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225628
NC_016751.1\|WP_014295939.1\|427313_427985_+\|Crp/Fnr-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223736
NC_016751.1\|WP_014295941.1\|429151_430282_-\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|277318
NC_016751.1\|WP_014295928.1\|408841_409819_-\|type-III-B-CRISPR-module-associated-protein-Cmr3	cmr3gr5	cd09748_cmr3gr5_CAS-III-B	gnl\|CDD\|187879
NC_016751.1\|WP_014295940.1\|427981_428980_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_016751.1\|WP_014295932.1\|416375_418568_-\|DUF4230-domain-containing-protein	unknown	unknown	gnl\|CDD\|379417
NC_016751.1\|WP_041638747.1\|433434_433827_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|129116
NC_016751.1\|WP_148265186.1\|431948_433013_+\|peptide-chain-release-factor-1	unknown	unknown	gnl\|CDD\|234801
NC_016751.1\|WP_041638749.1\|433863_435786_+\|threonine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234752
NC_016751.1\|WP_014295947.1\|437222_438509_+\|cyclic-nucleotide-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|237999
NC_016751.1\|WP_014295942.1\|430338_431880_+\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224099
NC_016751.1\|WP_014295934.1\|419451_421776_-\|trypsin-like-peptidase-domain-containing-protein	unknown	unknown	gnl\|CDD\|223343
NC_016751.1\|WP_014295948.1\|438519_439527_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340831
NC_016751.1\|WP_014295929.1\|409805_412166_-\|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	cas10	cd09679_cas10_CAS-III	gnl\|CDD\|187810

Protein	Function_ID	Function_description	E-value
NC_016751.1\|WP_014295946.1\|435921_437202_+\|cyclic-nucleotide-binding-domain-containing-protein	gnl\|CDD\|237999	cd00038, CAP_ED, effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels.	8.5772e-12
NC_016751.1\|WP_014295947.1\|437222_438509_+\|cyclic-nucleotide-binding-domain-containing-protein	gnl\|CDD\|237999	cd00038, CAP_ED, effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels.	2.14142e-15
NC_016751.1\|WP_014295929.1\|409805_412166_-\|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	gnl\|CDD\|187810	cd09679, Cas10_III, CRISPR/Cas system-associated protein Cas10. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Multidomain protein with permuted HD nuclease domain, palm domain and Zn-ribbon; MTH326-like has inactivated polymerase catalytic domain; alr1562 and slr7011 - predicted only on the basis of size, presence of HD domain, and location with RAMPs in one operon; signature gene for type III; also known as Crm2 family.	6.32108e-85
NC_016751.1\|WP_014295931.1\|414675_416343_+\|AAA-family-ATPase	gnl\|CDD\|313108	pfam09820, AAA-ATPase_like, Predicted AAA-ATPase. This family contains many hypothetical bacterial proteins. This family was previously the N-terminal part of the Pfam DUF1703 (pfam08011) family before it was split into two. This region is predicted to be an AAA-ATPase domain.	4.45105e-64
NC_016751.1\|WP_014295937.1\|424180_424693_+\|DUF1232-domain-containing-protein	gnl\|CDD\|225876	COG3339, COG3339, Uncharacterized conserved protein [Function unknown].	1.1615e-07
NC_016751.1\|WP_014295930.1\|412162_413416_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr1	gnl\|CDD\|224286	COG1367, COG1367, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	4.35042e-25
NC_016751.1\|WP_014295934.1\|419451_421776_-\|trypsin-like-peptidase-domain-containing-protein	gnl\|CDD\|223343	COG0265, DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones].	3.98357e-32
NC_016751.1\|WP_014295939.1\|427313_427985_+\|Crp/Fnr-family-transcriptional-regulator	gnl\|CDD\|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	7.80557e-24
NC_016751.1\|WP_014295941.1\|429151_430282_-\|metallophosphoesterase	gnl\|CDD\|277318	cd00839, MPP_PAPs, purple acid phosphatases of the metallophosphatase superfamily, metallophosphatase domain. Purple acid phosphatases (PAPs) belong to a diverse family of binuclear metallohydrolases that have been identified and characterized in plants, animals, and fungi. PAPs contain a binuclear metal center and their characteristic pink or purple color derives from a charge-transfer transition between a tyrosine residue and a chromophoric ferric ion within the binuclear center. PAPs catalyze the hydrolysis of a wide range of activated phosphoric acid mono- and di-esters and anhydrides. PAPs are distinguished from the other phosphatases by their insensitivity to L-(+) tartrate inhibition and are therefore also known as tartrate resistant acid phosphatases (TRAPs). While only a few copies of PAP-like genes are present in mammalian and fungal genomes, multiple copies are present in plant genomes. PAPs belong to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	1.1417e-26
NC_016751.1\|WP_014295928.1\|408841_409819_-\|type-III-B-CRISPR-module-associated-protein-Cmr3	gnl\|CDD\|187879	cd09748, Cmr3_III-B, CRISPR/Cas system-associated RAMP superfamily protein Cmr3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; This protein is a subunit of Cmr complex.	1.55475e-57
NC_016751.1\|WP_014295940.1\|427981_428980_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	6.90512e-121
NC_016751.1\|WP_014295932.1\|416375_418568_-\|DUF4230-domain-containing-protein	gnl\|CDD\|379417	pfam14014, DUF4230, Protein of unknown function (DUF4230). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 203 and 228 amino acids in length.	0.000121753
NC_016751.1\|WP_041638747.1\|433434_433827_+\|hypothetical-protein	gnl\|CDD\|129116	TIGR00004, RutC_family_protein, reactive intermediate/imine deaminase. This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other].	1.70999e-46
NC_016751.1\|WP_148265186.1\|431948_433013_+\|peptide-chain-release-factor-1	gnl\|CDD\|234801	PRK00591, prfA, peptide chain release factor 1; Validated.	0
NC_016751.1\|WP_041638749.1\|433863_435786_+\|threonine--tRNA-ligase	gnl\|CDD\|234752	PRK00413, thrS, threonyl-tRNA synthetase; Reviewed.	0
NC_016751.1\|WP_014295948.1\|438519_439527_+\|glycosyltransferase	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	2.65422e-32
NC_016751.1\|WP_014295933.1\|418564_419431_-\|hypothetical-protein	gnl\|CDD\|225628	COG3086, RseC, Positive regulator of sigma E activity [Signal transduction mechanisms].	0.00386325
NC_016751.1\|WP_014295942.1\|430338_431880_+\|iron-ABC-transporter-permease	gnl\|CDD\|224099	COG1178, ThiP, ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism].	1.09392e-45

>NC_016751.1|WP_014295937.1|424180_424693_+|DUF1232-domain-containing-protein
MPNNNFKDFENEVNSYENKVEIESDSFYKKLRNKIKKWAGKNKDNKILEYILLAPDLFYFFLTVLKDKDVYVDYKLKITGYLAYFISPIDIMPEMVLGPAGYLDDVLMGLLFLRTLLKELPYEYVEEKWPGDKEVLKNVSVMIDNIQAIIDSKIFRSVMSYFSKNIEKKK
>NC_016751.1|WP_014295936.1|423268_424153_+|hypothetical-protein
MKKILLFFLLSFLTVFVYAQILLSTEGKKILEEELNRFNIEVINEIDNTTEKIYNKIADYEKYSKIFVEDITDLGSTSKSIYYMSKDSLLKLIKRNSNSYENYIKKMFEHHFFNEEKIKKIIVDEINIFNIKINEKLYTFIENLDKKLSMEDKKILENDDDFKSFVNAFDVNGIFKNNNEIFSEQIINLVSTHQNSILKKKLFSATLKSGSIVGSFWISLSTQNPIFVATSIFYTIILTLNSEKNNIKKEELAVEISSQIEKYADNISNIVKKLLSQTIDTEINKIKKSFNLLY
>NC_016751.1|WP_014295935.1|421907_423257_+|hypothetical-protein
MDEKIIFSILNHENDIIYKKYLNNEFLFGESIETTITPLHAAIISDNIEVIKLMEKSGYNIVYALLNNNDILNPYILAKRLDREEIVEYFDEILEQNLNTDLKNTENFKYIEIEKVFEDILKDAENKQKIQEFLEKFLKHPKNLLLETNIAKRIFCEIPNEELVFFIKKIIDVLTDEYCSMFLYEFLDPKCKLASVYALIRIKESQNIAVYYNEKYINRLIDIYDIFMLNDDEDKITYLETINRFYIEELSEDIKDLFFETQNDKLKYITYKILLKYELEELFEITKEAMKSNYLPLKELATLICILKYENNCKKQDNIKFENLREEDYIAISLFDTPYVEDIIYKKFSTFSYDTKLNIIHNLIIISSKRRYNMLLDIYKFEKNPEIKAEIIYQFIIREIYTPEILKVFIEDFIKNLDEYNSYDDNEDFNIFSALGHYFANILMKKELF
>NC_016751.1|WP_014295934.1|419451_421776_-|trypsin-like-peptidase-domain-containing-protein
MKKSFFLLFIVLLIFSIFSFGDIKILNISMEDRDELFYYAPIVTNNYIILASPGTPDKDYNDAGIYLLDKENLEILDVFKTYSPVSIVSGECFYPGYFSTYYAYYDNTLISFYVSDSEKISVEWKKSFEYKDIEITNDFDNDFIIKENKLNARKNDIIIKINDEYLYNYSDMAKYLENYSEDVATLHLLRNNSNISYVYKTNIVTKPDYIISGVIYRDEFDFSDNLFIQTEKYIYQLDYEGNIINRYYAEKKSHKLPPTFSDLNQDGKIEVVFFEDNYIKILDNGNLIKIDFDYWYQDEEDIFAPISTVYYADVDNDYYPEGVFVDKNFTINYIEYDPTTKSYYISYSELPNKGNYKYPLVSGNVVYDFNFTGDLLTLITYNKEIYMLSSDEKIISKKILKFPIISRPYIYWKNGWFIVLTQYDFDNEKTFLTKLKYKDEKFEIIDTYEYNGFYLLEGYIPYNDNIYALLCSSENTILQYIEKDGTEIFEAYKTYMSNNNNFIDYIQTFKKHDLKNKLLIAERGEEIISPEEIAKKMESVVRINNYVYSSYEELEGSGSGFIIAEDDFYYYIATNAHVVSTIGEDITKDISYYGLSITFFNGETVSPEEVFINTTFKDIAILSISKFYLDNTYPVLPLGLYSHTIGTKVYALGNPEGLDFTFTQGIISALRFARINEFYNINNNKFFELIQTDAAINHGNSGGPLIDKYGNVIGINSLGGDKNITEGLNFAISANDLYYEIKKDNFIKLFYDSRLPNDWLFKTLKNKFSKYYNY
>NC_016751.1|WP_014295933.1|418564_419431_-|hypothetical-protein
MDEQDKVKKKNGMLKRFAVILFYIGIFILFVFIFNYFFPVENEVSAPKKSYFDNIEYIVFKEIQFNNYIVYKDNNQNKARVYYIKGRAEIKFNVEDLKKRIESDSVTGKEIVYISIPQKDMLKIDVEIENSKEIDTFPIEVKSNNSNLMDITEKFSPVVGTVLGAWIGSKLTNISILKNFKAINIVGTLGGAVGGYLLTKHFVRKLEKSSSQSSNTVNDLSLGLDEEIKAKAKDLIALEFLYGNDNEFKKDIIEYYKSEFLKAVKPLYSIQDENVEVVWDNSLLEVIQ
>NC_016751.1|WP_014295932.1|416375_418568_-|DUF4230-domain-containing-protein
MKKMIIRILTLALIIGIAFLVSRYNIISNFFAKSKEVSVQIPSLNIEAIRDLAQLRVFSYNMDFLFIAKDENNNYYVAIYPYTVEAGIDLNKIKSEEKVYSKGVIYFPSPEIFYYGESFDKKPIIVTDQIKIDSSYYKDNIKEGFKMYSRDIAINKGIYEKTEKALKEYLKKFVPEEYDLKFSEPDNNFTKINAERFQAYFKLTNELYRKYKFSDENGKYFAEFLNKEDPEIKFTFNFSQEYKKDHKTFFNDVESKFKGELCYKLVNPDNPFDYNYSFKINRNKNTLIGFILNGGDLINFKFNTQNEEDFKKYTSDFIYYMFAYRNSQNKNYTEVGKYKDFINYLYKSQIAIDEEKINTLENLGENILSLQRDVYSEYGNLFINLEKLIEKNIDTSENINDYNLKLLAKAYYYINNKDKRIIELIDDLKTWFEKNENIENAFEPYLMQEYYNWNINEKISLLKDKVMTYLMINYKNYLKNDEIEKYKREIINEGIYYSNVWNNIINSDIERKEYLKRIYLNIVKNQKLEHYLYYDKDKKLVRIKDFNDPDFYLSDIYYDFQVKDKYNNIILDSDSLANAFVEMYEKFSEKEKENFKSLIKDNFDDEYYFFSDVNSKKFFKNNFIIVLTRNAFNLPKNAFKVYTVFVFGKNGLLLFETSKKIFGDGFKLKYQKFIEYSELPEKLEHKNASIKAILDVLNDTESNNLTEEICENLKYLIRFILRNKVNVFVL
>NC_016751.1|WP_014295931.1|414675_416343_+|AAA-family-ATPase
MKELKSLPLGESNFKTIMENNMYFIDKSMLIKDILSAGRVILITRPRRFGKTLNMSMLEHFFSMKKNSESLFKDLKIWNEKKIIEKYLNKYPVIFISFKGLKKKKYEDMKNGIRELISKLYTKYVYLLNTDKITQWDKKRIIGILDKTAEDAVFEDGIKNLTEYLYIYHGKKVILLIDEYDTPIQQSYLNGYYDELIDFIGNILGNALKDNEYLEKAVLTGITRVAKESIFTGVNNLQISTVLSRLFNDKFGMTKEELHEALKYYGMEYEEEKIIEWYNGFNFGGFEIYNPYSIMNLIFEKEIKNYWINTSGNKLIKDLIAKGSAEIKSKIYDLIEGETVTTTINENLVYGDLNVNVEESVWTLFLFTGYLTWIDKIGEGNSAEYRLKITNKEALDFFKKTVVNILEDSGFKYKTLLKDLIEENYEEFKENFKELVENTISYFDVSGKEPERFYHGLILGLSVGLQKEYIIKSNRESGYGRADLILIPKKRSNPGIIFEFKKYYKKDGDLKSSAEKGMKQIEEKNYETEIKSHGIERIIKVAIAFDKKEVEIVIK
>NC_016751.1|WP_014295930.1|412162_413416_-|type-III-B-CRISPR-module-RAMP-protein-Cmr1
MNILEFELLTTSPMFASRDGKTFSLTPQSVRGVMRFWFRAVVPRVIDIHYYNGERKPYIGLKKAEELIFGSTERKSSFDVIVDLISPTNITNNHDYFTFARINKRNRKINYIYGIYGVEEREFLKEKSKLNITFIIKKQPDKLLNIIINLMNLISLVSGFGAKTRKGFGSFKIELIKTNKENSSEIKNSVKNILNELDENLKRYFSSISDTHFKYSQTEFLDIPEFPVLLSDPKTYRVVSTKKSPIKNFSDIYKKLYATEMQESKKGVYIKVKKKLRTLNNTDSFTNALREVEASSKNTIESNIIFYQALMGLPINYKYNITSKKLRNYKGNEYTLTNGERKASPFFFSFHLNEKNEYYVRILMITSKISLNNKIYFEGRRNKLITESPESFEIYNQAMDIFKKEVEKKLTNKGEKK
>NC_016751.1|WP_014295929.1|409805_412166_-|type-III-B-CRISPR-associated-protein-Cas10/Cmr2
MNWEKKIIALLHDPIEKALNLEKHENIANRRLNKLGTYLKDDYKNPDYLSSAADRILFPKEKEHFSKRISINIYHYPEYLHPLNGEKLEDYFKNDFKQKIDKLNSEKITDKLEKLEDFKKTYYKTWWELPEQTELSFMLPGDTRIPSHSIIDHLDSASAMSVSNKMSLLLVSIGPVQEFIAAARKTIDLKVGSYMLSYLTFQGIKVIGEEYGYDNVIFPYMRGNYFVKKEFEKIGIFVETSADPGVASLPNIFTAIVPTKDLEKIKSKIKKAIKDEMSNISQFIKIYIEDLIQSEKKYKETIFQKLEAFKNWDKQISQFPIIITVDQEINNIEKYIEKHYIYTEDENIKKLYQKMKQLESTYQMKDIAFYGMYSELLGIKSSLRKTTRDFIQLFEDDVVNGDDLSGANKAVIEIIDKDEKKERLSALSAIKRLFVEYLNEIGYKEAYEKLKYVKSTEEIAGKYKLAVLLMDGDNMGKWISGTLAPSFKKRLHSKVIKELEREDKEYTKLLENINLVTPSYQRMISRTLNNFSNFVPKVVEEFDGLLIYAGGDDVLALFPSNKVFDAANKLRKVYSGIGEEKVGEYVFKNGWCYKKEKNLEYPVFNMMGKQATMSAGIVISKHNFNLKLALNKAREMEKLAKSNEEKSGRKKDSFAIATIRRSGQINISKSFWELNRFDILLKGLEFIKDFEKEKSIKNIILRLKSEYINYCFDEFGNEILTIEDFKNNIIPFLEKRMEIKKDKLKNSFVKLITLNERFLTGNKLMEYFNTLENIEYARRENIYEKN
>NC_016751.1|WP_014295928.1|408841_409819_-|type-III-B-CRISPR-module-associated-protein-Cmr3
MKKIKTLFIKPVDWVGFRKSKTFSHAEETIFPNPKTFYGAIMTAYMRKKNLTQEEIEQIIKDKKLKIIGPFLTDSESNIYFRMPAIIKQNDITKEFYKGEIDETFTFNLNGKELYGIKYKSMRNLKEPEKTYISLNELEELKKGNLKISNDNSEIYFKEEKIGIALENRKAMEGMLYSYSYFRFIDDAGFAFFIERDELNILNEIEIITLGTKGKMAKIEIKEIETSIFDPIIDTQKGLLLLTPAYFEDGVKPIFDSNIIAIANYKPETIGYWDLKNNHPGEQFKVVPSGSVYVIKGDFEKENYKINFTDKYDEYNFGKYIEIKI
>NC_016751.1|WP_014295939.1|427313_427985_+|Crp/Fnr-family-transcriptional-regulator
MQQIFEQISKTPIFKSLKITEIEELISSEKMIIKSYEKDEIIRFRGEKVNEVMILLSGQVKAEMSDTQGKIIEIEEIKAPNLLAVGATFSKNSIIPVDIIAIEKSTVAFINKDEVLNLCMHNKDFLQELIEYLGTKFVFISQRLWFITLNNIKDKILFHIKGKLKDSSDDYVILEYSVEQLSHLFGVTRPSLSRAFSKLEEEGIIKKEGNKIYILNKNIFKDF
>NC_016751.1|WP_014295940.1|427981_428980_-|LacI-family-DNA-binding-transcriptional-regulator
MKRINIKDVAKEAGVSISTVSRVINKSAPVKEELRKKVEEAIKKLEYKPSIVARSLRKGKAKTIGLVIPDITDPYFPHIVKGIEDYLKKEDYTLLLSNSGQDLEQETKIIETFESNHIDGVIFIGSGLTNPYLKHLKERGIKVVYLDRILKGIDVSYVVSDNKQGMHDLLQYLYDTNHRSFHFVNGNENTFSAQVRYEAFAEFMEKNNIKSYKHIYSCFSYDAGYQYGKEIDLKKLPDVIMGGNDLIAYGLMDALDERGVKIPDDVSITGFNDIPFSRHYKPSLTTVRQPIYKMGYTAANLIIQIINSDGPVFKGIVLKTELIVRNSTRRRD
>NC_016751.1|WP_014295941.1|429151_430282_-|metallophosphoesterase
MKKYILLFILLFSALYLFSKSLFLWPPYITYNGKDLFLNFKTNGIIKGLSIHIIDKNLNEVYSIKLQENELYHIPINIDYVNENFEYIIKQNSKVIYKNTFNEFNPLKKDFTFVVYGDTRYYDKLHRMIVDKIIEEKPDFVINVGDMVENGENINYWTNFFNTIKGLNIPYFPIPGNHEKNSKYYYDAFILPEGGGFQNKQWYSFKYGNLNFILLDSIIINNSELFKQETIWLEQTLKNNKNYINIIIFHYPFWNNSIYAWRRDNKILEKKWRPIFEKYNVKLVFNGHVHAYERFKLNDITYITTGGGGAPFDPGHKEKLNPYTQKIHYGYLEYVLLKVKAGKITVITKAVGKSDNYKMNNVKSLDMVLDFFEIDK
>NC_016751.1|WP_014295942.1|430338_431880_+|iron-ABC-transporter-permease
MRRIHLYIIIFAILWVFPVSILMINYFDFHTFLNVFFRARTLRILKNTVYQASLSTVFSFIISILPAIYVANNKNTLSKILENSFFIPFFFPPISTIISFSILYGNNGIINKIFGLNILYTLTAIIIAHSFYNSPIFVKYISDALRNIPKNYIENAIIDGASKKDIIRFIKVPLIIPSVLKGGFLVFMYSFVSFAIVLSLGGIKYSTFEVAIFTTLRSSLNFSKALSYALIQFLILIILNFIISLPKIHEIPSEELYVSKTSMITFFISIFYVLFEYSIVFVGIFSGFYDFINNRFTIKGLYNLFSKSLNKYYPVIKSIYNTTLIALIVGIISIFLSYIILRNIKNHKDMRFANIFIISSLGVSSTFIAMSLLILNIEFSIPYAILLIIGYLVISIPLGYTFLQQRVLSFDNSIIEAAKIDGANKFQTFLFIEMPILKNSLISSFLQIFAIVFGEFTISYTMQVSNYFPIVSNINYTLSNARYYLESQAMSSITVIIIFLIFYISTSLLKEEV
>NC_016751.1|WP_148265186.1|431948_433013_+|peptide-chain-release-factor-1
MLSFKEKVLEKLKEVEEKLADPDVTSNLDLLQSLGKEHNRLSTLKELFEKYEGITEDIKALEELKHAEEIDEEEYNSMVEESEKNLKSCYLEILSLLIPGNEINERNIIMEIRAGTGGEEAALFASDLMRMYLRYAENKGWKHEIMELSDTGIGGTKNAVIKIKGKGVFGRLKYESGVHRVQRVPVTESGGRIHTSTATVAVLPEATDVDVKIEDKDLRIDTYRAGGAGGQHVNKTESAVRIVHLPTGIVVTCQNERSQHQNKEAAMSILRAKLYEEALRKQHEELTSQRRSQIGTGERSEKIRTYNFPQNRVTDHRIGYTSYRLGFILDGDLDEIIDKLMEWDLTEKLENLEI
>NC_016751.1|WP_041638747.1|433434_433827_+|hypothetical-protein
MRLKLFNNKKSVTPKNFSAVGPYSHAILKDDELFISGQLPINYETGEIPESFVEQTKQVMENIKTILKSSGFSLKDVVQVQVFLTDMSKFNEFNVVYENYFKKIYPARFVIEVSKLPKDAMVEIACIAKK
>NC_016751.1|WP_041638749.1|433863_435786_+|threonine--tRNA-ligase
MIKIVLPDGSEKEYKKGITAAEIAKGISEGLYRQSVGALVNGELYDLTRPIEVDATVKLITDKDPEAPVIFRHTMAHIMAQAVMRIYGKDVKLAIGPVIENGFYYDFDMEEKISEEDLEKIEAEMKKIIKEDLKIERFEISKEEAKKMFEEMNQPYKVELLEDIEDDTVTYYKQGEFIDLCRGPHLPSTGKIKQFKLLSVSGAYWRGDERNKMLQRIYGTAFAKKAQLDEYLKMLEEAKKRDHRKLGPKLELFMFDSELAPAMPFFLPRGAKVINQLIEFSRELHKKYGYEEILTPLMMNVKLWHQSGHWDHYKENMYFTEKDEMEYAIKPMNCPGHILIYKSKVVSYRDLPIRYSEFGKVHRYERSGVVHGLFRVRAFTQDDAHIFCTKDQIEEEVIKVMDFTNELYNAFGFEYEANLSTMPEDHMGDEKTWEIATNALKAALEKSGINYNINEGDGAFYGPKIDFQIKDSLGRKWQCATIQLDFQMPERFDIHYVDHNNELQRPVMIHRAIYGSIERFFGILIENFAGAFPTWLAPEQVAVIPVSDKYVEFSKEIAAKLDKEGIRVKLDDSNATVGYKIRNAQLLKIPYMIVIGEKEVESNKFNVRTREGNTVEDISLEDIIKTIHEEVKNRSLKLSY
>NC_016751.1|WP_014295946.1|435921_437202_+|cyclic-nucleotide-binding-domain-containing-protein
MIKKYKNDEILQLENEDPIALVVLKNGHLLSESKFCNYKKVFIKKGIFSEEFLFNIKTIESLRNVRNSEVELITDKKEAEEFLKNNKELLSLAIKKRIKMLVNMNDKIATDFFTKKNQRRLAEDFKTEIEVEEVKKIFKKIYKYNWHYFSDDFIQKYISARELILSEEYEEAYENLKNIDLSNIEDKYFKAEIEIWKIYCLYFMQNNNYEKMLETLHYKYDFLNELISFFILNKSIKDKKIDSNLKTYFKKGYLIPAKTVLFFEGEEGDWSFLNVSGSVYISKFLDNKEILLNILTEGEIVGEIAVIENVQRTATVFTKTPLQFIYITSDNLESLINESYLLGRNILKALIKRVDFQKKLIANTDLIDKTKVLINKYSRQRLNKFKLTPQQFLNLSGLTMDISEFITILSKNKISTIRPDGTLYFK
>NC_016751.1|WP_014295947.1|437222_438509_+|cyclic-nucleotide-binding-domain-containing-protein
MKERLYAPETILVNEGNEVENLIILKEGMLETTSSFCAHHSYETKGIFGAELLIPGIKSFESIRVIENSRVLLLEKELVEKFLLSNSSLVIYLIKKYIEKIISLNKKIFGDIKKENENKKNSEHLIDKNLDVVDISKKYLKRHRRREYTSIKDHNIQLYENGRKLFNAGKIKEALNEFKKIQFNKFDMYFQAEVEIWKDLCMILISPDKKYYLEKTLREKYPFIKELFSFMVFESVITNKPLIKPLVTYLKSGYLLPSHTVLFHEGEEGDWAFMILSGNVRVSKFSPHGEKLLAILSNEEIVGEIACFKDVERTATVFTSTPLQMIKIEKNNLDSLVTNDPGFGLKIVKKLIMRLEFERYWASPMNFDEKLTYMIKKYGKNTLNKSHLKIEEILSLFRITDKKPNEVIDYLFKSNIARLRTDGTLKFI
>NC_016751.1|WP_014295948.1|438519_439527_+|glycosyltransferase
MKILLFSEGKNMFQRSGVGKALQLQQEALKLAGVDYTLNPEDNYDIVHINTIGFTSEKILKEAKKKGKKIIVHTHTTYEDFRNSFIFSNQLAFFIKKRLIKMYSNADFLISPTKYTQNLVRSYGIKTKSAVVSNGVDTNKFKYNAKSAIKFKEKYKLNKPLILSVGLPFERKGILDFYKLAKKLPQFQFIWLGAKMKIVPKKIRKILNEKSIKNLLFPGYIPTEDLINAYSAADIFLFPSYEENEGIVVLEALSSQTPLIIRDIPVYKDWLTNEVNCLKSSSLEDFEKNIFKIINKEIDVEKLKENERIVALERDLKVIGEKLKNIYGDLYAEKV

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_016751_1	1.13\|290752\|35\|NC_016751\|CRT	290752-290786	35	KT895374	Bacillus phage vB_BpuM-BpSp, complete genome	6341-6375	8	0.771
NC_016751_2	2.14\|294151\|36\|NC_016751\|CRISPRCasFinder	294151-294186	36	MK250029	Prevotella phage Lak-C1, complete genome	318485-318520	8	0.778
NC_016751_2	2.14\|294151\|36\|NC_016751\|CRISPRCasFinder	294151-294186	36	MK250016	Prevotella phage Lak-A1, complete genome	353267-353302	8	0.778
NC_016751_2	2.14\|294151\|36\|NC_016751\|CRISPRCasFinder	294151-294186	36	MK250019	Prevotella phage Lak-A2, complete genome	272790-272825	8	0.778
NC_016751_1	1.13\|290752\|35\|NC_016751\|CRT	290752-290786	35	NC_019507	Campylobacter phage CP21, complete genome	101668-101702	9	0.743
NC_016751_1	1.13\|290752\|35\|NC_016751\|CRT	290752-290786	35	MT932329	Campylobacter phage F379, complete genome	165001-165035	9	0.743
NC_016751_1	1.13\|290752\|35\|NC_016751\|CRT	290752-290786	35	MK408758	Campylobacter phage CP20, complete genome	9225-9259	9	0.743
NC_016751_1	1.13\|290752\|35\|NC_016751\|CRT	290752-290786	35	HE815464	Campylobacter phage CP21 complete sequence	101668-101702	9	0.743
NC_016751_1	1.13\|290752\|35\|NC_016751\|CRT	290752-290786	35	FN667789	Campylobacter phage CPt10, complete genome	9225-9259	9	0.743
NC_016751_1	1.13\|290752\|35\|NC_016751\|CRT	290752-290786	35	MG967616	Bacillus phage v_B-Bak1, complete genome	50294-50328	10	0.714
NC_016751_1	1.13\|290752\|35\|NC_016751\|CRT	290752-290786	35	KC595511	Bacillus phage Basilisk, complete genome	51328-51362	10	0.714
NC_016751_1	1.13\|290752\|35\|NC_016751\|CRT	290752-290786	35	MG967618	Bacillus phage v_B-Bak10, complete genome	51777-51811	10	0.714
NC_016751_1	1.13\|290752\|35\|NC_016751\|CRT	290752-290786	35	MG967617	Bacillus phage v_B-Bak6, complete genome	50294-50328	10	0.714

1. spacer 1.13|290752|35|NC_016751|CRT matches to KT895374 (Bacillus phage vB_BpuM-BpSp, complete genome) position: , mismatch: 8, identity: 0.771

agaaattgaaaatttaaacttagaagcaaatttaa	CRISPR spacer
tgaaattgaaaatttaagattagaagaatttatta	Protospacer
 ****************. ******* *  * * *

2. spacer 2.14|294151|36|NC_016751|CRISPRCasFinder matches to MK250029 (Prevotella phage Lak-C1, complete genome) position: , mismatch: 8, identity: 0.778

-taaaaataaaaattaaattcttttgcatttaacata	CRISPR spacer
cttgtcat-ataattaaattatttagcatttaacata	Protospacer
 * .  ** * ********* *** ************

3. spacer 2.14|294151|36|NC_016751|CRISPRCasFinder matches to MK250016 (Prevotella phage Lak-A1, complete genome) position: , mismatch: 8, identity: 0.778

-taaaaataaaaattaaattcttttgcatttaacata	CRISPR spacer
cttgccat-ataattaaattatttagcatttaacata	Protospacer
 * .  ** * ********* *** ************

4. spacer 2.14|294151|36|NC_016751|CRISPRCasFinder matches to MK250019 (Prevotella phage Lak-A2, complete genome) position: , mismatch: 8, identity: 0.778

-taaaaataaaaattaaattcttttgcatttaacata	CRISPR spacer
cttgccat-ataattaaattatttagcatttaacata	Protospacer
 * .  ** * ********* *** ************

5. spacer 1.13|290752|35|NC_016751|CRT matches to NC_019507 (Campylobacter phage CP21, complete genome) position: , mismatch: 9, identity: 0.743

agaaattgaaaatttaaacttagaagcaaatttaa	CRISPR spacer
agaatttgaaaatttagacttagaaagcaaaaaag	Protospacer
**** ***********.********.  **   *.

6. spacer 1.13|290752|35|NC_016751|CRT matches to MT932329 (Campylobacter phage F379, complete genome) position: , mismatch: 9, identity: 0.743

agaaattgaaaatttaaacttagaagcaaatttaa	CRISPR spacer
agaatttgaaaatttagacttagaaagcaaaaaag	Protospacer
**** ***********.********.  **   *.

7. spacer 1.13|290752|35|NC_016751|CRT matches to MK408758 (Campylobacter phage CP20, complete genome) position: , mismatch: 9, identity: 0.743

agaaattgaaaatttaaacttagaagcaaatttaa	CRISPR spacer
agaatttgaaaatttagacttagaaagcaaaaaag	Protospacer
**** ***********.********.  **   *.

8. spacer 1.13|290752|35|NC_016751|CRT matches to HE815464 (Campylobacter phage CP21 complete sequence) position: , mismatch: 9, identity: 0.743

agaaattgaaaatttaaacttagaagcaaatttaa	CRISPR spacer
agaatttgaaaatttagacttagaaagcaaaaaag	Protospacer
**** ***********.********.  **   *.

9. spacer 1.13|290752|35|NC_016751|CRT matches to FN667789 (Campylobacter phage CPt10, complete genome) position: , mismatch: 9, identity: 0.743

agaaattgaaaatttaaacttagaagcaaatttaa	CRISPR spacer
agaatttgaaaatttagacttagaaagcaaaaaag	Protospacer
**** ***********.********.  **   *.

10. spacer 1.13|290752|35|NC_016751|CRT matches to MG967616 (Bacillus phage v_B-Bak1, complete genome) position: , mismatch: 10, identity: 0.714

agaaattgaaaatttaaacttagaagcaaatttaa	CRISPR spacer
gtgttttgaaaatttaaacttagaaacagatattg	Protospacer
. .  ********************.**.** * .

11. spacer 1.13|290752|35|NC_016751|CRT matches to KC595511 (Bacillus phage Basilisk, complete genome) position: , mismatch: 10, identity: 0.714

agaaattgaaaatttaaacttagaagcaaatttaa	CRISPR spacer
gtgttttgaaaatttaaacttagaaacagatattg	Protospacer
. .  ********************.**.** * .

12. spacer 1.13|290752|35|NC_016751|CRT matches to MG967618 (Bacillus phage v_B-Bak10, complete genome) position: , mismatch: 10, identity: 0.714

agaaattgaaaatttaaacttagaagcaaatttaa	CRISPR spacer
gtgttttgaaaatttaaacttagaaacagatattg	Protospacer
. .  ********************.**.** * .

13. spacer 1.13|290752|35|NC_016751|CRT matches to MG967617 (Bacillus phage v_B-Bak6, complete genome) position: , mismatch: 10, identity: 0.714

agaaattgaaaatttaaacttagaagcaaatttaa	CRISPR spacer
gtgttttgaaaatttaaacttagaaacagatattg	Protospacer
. .  ********************.**.** * .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

301978 : 345545

Marinitoga_camini_virus(88.37%)

holin,tail,head,capsid,terminase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014295814.1\|301978_303448_-	recombinase family protein	A0A142LP20	Marinitoga_camini_virus	3.8e-240	85.9
WP_014295815.1\|303450_303612_-	hypothetical protein	A0A139ZPH6	Marinitoga_camini_virus	1.3e-16	77.4
WP_014295816.1\|303768_304140_-	STAS-like domain-containing protein	NA	NA	NA	NA
WP_014295817.1\|304156_305122_-	STAS domain-containing protein	NA	NA	NA	NA
WP_148265182.1\|305173_306880_-	DUF4041 domain-containing protein	A0A142LP25	Marinitoga_camini_virus	6.1e-149	89.4
WP_014295819.1\|307116_308673_-	restriction endonuclease	A0A2L1IZ21	Streptomyces_phage	2.1e-108	39.0
WP_014295820.1\|308751_309372_-	helix-turn-helix domain-containing protein	A0A139ZPI6	Marinitoga_camini_virus	3.0e-45	45.3
WP_014295821.1\|309556_309766_+	helix-turn-helix transcriptional regulator	A0A139ZPI8	Marinitoga_camini_virus	3.7e-08	54.3
WP_014295822.1\|309849_310299_+	hypothetical protein	A0A139ZPJ8	Marinitoga_camini_virus	9.7e-38	57.8
WP_014295823.1\|310383_312429_+	hypothetical protein	A0A1L2K2K3	Aeribacillus_phage	3.7e-68	27.8
WP_041638719.1\|312443_313394_+	recombinase RecT	A0A1L2JY28	Aeribacillus_phage	4.9e-63	44.5
WP_014295825.1\|313393_314122_+	MBL fold metallo-hydrolase	A0A1L2JY21	Aeribacillus_phage	2.3e-60	47.2
WP_014295826.1\|314219_314987_+	conserved phage C-terminal domain-containing protein	A0A2H4J1Z1	uncultured_Caudovirales_phage	1.4e-15	51.8
WP_014295827.1\|314991_315246_+	hypothetical protein	NA	NA	NA	NA
WP_014295828.1\|315199_316474_+	replicative DNA helicase	A0A139ZPD0	Marinitoga_camini_virus	1.8e-161	66.0
WP_014295829.1\|316478_316946_+	single-stranded DNA-binding protein	A0A139ZPL3	Marinitoga_camini_virus	1.2e-27	45.1
WP_014295830.1\|316949_317369_+	dUTP diphosphatase	A0A139ZPL6	Marinitoga_camini_virus	7.6e-61	80.6
WP_014295831.1\|317368_317569_+	hypothetical protein	NA	NA	NA	NA
WP_014295832.1\|317571_317820_+	hypothetical protein	A0A139ZPD3	Marinitoga_camini_virus	4.7e-10	53.1
WP_014295833.1\|317803_318169_+	RusA family crossover junction endodeoxyribonuclease	A0A139ZPD4	Marinitoga_camini_virus	1.8e-45	71.9
WP_014295834.1\|318180_318645_+	hypothetical protein	NA	NA	NA	NA
WP_014295835.1\|318641_318914_+	hypothetical protein	NA	NA	NA	NA
WP_014295836.1\|318913_319189_+	hypothetical protein	NA	NA	NA	NA
WP_014295837.1\|319175_319406_+	hypothetical protein	A0A139ZPD5	Marinitoga_camini_virus	5.5e-29	85.5
WP_014295838.1\|319422_319905_+	sigma-70 family RNA polymerase sigma factor	A0A139ZPD6	Marinitoga_camini_virus	3.0e-37	49.1
WP_014295839.1\|320046_320373_+	type II toxin-antitoxin system MqsR family toxin	NA	NA	NA	NA
WP_041638431.1\|320378_321398_+	DUF4065 domain-containing protein	NA	NA	NA	NA
WP_014295841.1\|321838_322219_+	helix-turn-helix domain-containing protein	A0A139ZPD9	Marinitoga_camini_virus	6.1e-49	78.6
WP_014295842.1\|322202_323450_+\|terminase	PBSX family phage terminase large subunit	A0A139ZPM4	Marinitoga_camini_virus	2.8e-236	96.9
WP_014295843.1\|323452_324667_+	hypothetical protein	A0A139ZPM5	Marinitoga_camini_virus	2.7e-215	92.8
WP_014295844.1\|324671_326177_+	hypothetical protein	A0A139ZPM7	Marinitoga_camini_virus	1.9e-250	84.8
WP_014295845.1\|326161_326443_+	hypothetical protein	A0A139ZPM8	Marinitoga_camini_virus	2.6e-25	67.7
WP_014295846.1\|326544_327147_+	DUF4355 domain-containing protein	A0A139ZPE8	Marinitoga_camini_virus	5.3e-55	80.0
WP_014295847.1\|327165_327519_+\|head	head decoration protein	A0A139ZPN0	Marinitoga_camini_virus	6.2e-56	94.0
WP_014295848.1\|327534_328554_+\|capsid	major capsid protein	A0A139ZPN1	Marinitoga_camini_virus	1.1e-177	91.2
WP_014295849.1\|328619_328802_+	hypothetical protein	A0A139ZPF1	Marinitoga_camini_virus	1.0e-17	80.0
WP_014295850.1\|328773_329094_+	hypothetical protein	A0A139ZPF2	Marinitoga_camini_virus	6.9e-46	85.8
WP_014295851.1\|329083_329557_+	hypothetical protein	A0A139ZPN4	Marinitoga_camini_virus	3.3e-84	97.5
WP_014295852.1\|329549_329936_+	hypothetical protein	A0A139ZPN5	Marinitoga_camini_virus	8.0e-57	88.8
WP_014295853.1\|329932_330898_+	hypothetical protein	A0A139ZPN6	Marinitoga_camini_virus	4.1e-158	87.5
WP_014295854.1\|330915_331266_+	hypothetical protein	A0A139ZPN7	Marinitoga_camini_virus	1.8e-55	94.0
WP_014295855.1\|331282_331780_+	hypothetical protein	A0A139ZPN8	Marinitoga_camini_virus	2.5e-63	70.4
WP_014295856.1\|331792_335872_+\|tail	phage tail tape measure protein	A0A139ZPN9	Marinitoga_camini_virus	3.1e-308	53.8
WP_014295857.1\|335917_336532_+	hypothetical protein	A0A139ZPG0	Marinitoga_camini_virus	3.2e-76	75.4
WP_014295858.1\|336566_336905_+	hypothetical protein	A0A139ZPP1	Marinitoga_camini_virus	4.0e-36	65.8
WP_014295859.1\|336911_338042_+	hypothetical protein	A0A139ZPG2	Marinitoga_camini_virus	1.9e-37	33.4
WP_014295860.1\|338552_342563_+	hypothetical protein	A0A139ZPP3	Marinitoga_camini_virus	0.0e+00	67.8
WP_014295861.1\|342577_342739_+	hypothetical protein	NA	NA	NA	NA
WP_148265183.1\|342768_343554_+	metallophosphoesterase	A0A139ZPP5	Marinitoga_camini_virus	1.0e-119	79.2
WP_014295863.1\|343558_343819_+	hypothetical protein	NA	NA	NA	NA
WP_014295864.1\|343823_344201_+	hypothetical protein	A0A139ZPG9	Marinitoga_camini_virus	8.4e-51	75.4
WP_014295865.1\|344369_344699_+\|holin	phage holin protein (Holin_LLH)	A0A142LP17	Marinitoga_camini_virus	1.1e-14	43.9
WP_014295866.1\|344685_344985_+	hypothetical protein	A0A142LP18	Marinitoga_camini_virus	8.2e-25	56.2
WP_014295867.1\|344981_345545_+	hypothetical protein	A0A139ZPH4	Marinitoga_camini_virus	2.7e-85	80.2

DBSCAN-SWA_2

371401 : 380016

Synechococcus_phage(28.57%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014295894.1\|371401_371812_+	AIR carboxylase family protein	A0A2P0VNU7	Tetraselmis_virus	1.9e-16	46.1
WP_041638732.1\|371814_372516_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A1D7SPE1	Cyanophage	3.1e-38	41.5
WP_014295896.1\|372512_372779_+	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_148265185.1\|372778_373450_+	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_014295898.1\|373436_375593_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	4.4e-136	38.7
WP_014295899.1\|375595_376951_+	amidophosphoribosyltransferase	A0A1B1ISH6	uncultured_Mediterranean_phage	3.0e-50	30.9
WP_014295900.1\|376968_377934_+	phosphoribosylformylglycinamidine cyclo-ligase	A0A0E3FZ01	Synechococcus_phage	5.9e-56	41.7
WP_014295901.1\|377948_378536_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	3.7e-29	44.7
WP_014295902.1\|378516_380016_+	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	Q58MG4	Prochlorococcus_phage	4.2e-61	46.2

DBSCAN-SWA_3

602881 : 611494

Bacillus_phage(50.0%)

tRNA,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014296113.1\|602881_603574_-	response regulator transcription factor	W8CYM9	Bacillus_phage	4.7e-31	33.8
WP_014296114.1\|603638_604529_-	HD domain-containing protein	NA	NA	NA	NA
WP_014296115.1\|604844_605795_+\|tRNA	tRNA lysidine(34) synthetase TilS	A0A2H4UTJ2	Bodo_saltans_virus	4.3e-11	27.9
WP_148265189.1\|605886_607689_+\|protease	ATP-dependent zinc metalloprotease FtsH	M4QMW8	Micromonas_pusilla_virus	1.9e-116	42.2
WP_014296117.1\|607663_608086_+	thioesterase	NA	NA	NA	NA
WP_014296118.1\|608116_608845_+	response regulator transcription factor	W8CYM9	Bacillus_phage	1.0e-36	38.3
WP_041638465.1\|608904_610200_+	PAS domain-containing protein	W8CYF6	Bacillus_phage	5.1e-31	33.3
WP_014296120.1\|610174_611494_+	pyrimidine-nucleoside phosphorylase	A0A0H3UZD4	Geobacillus_virus	2.2e-122	53.7

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_016751

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection