CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_016786	Corynebacterium diphtheriae HC01, complete sequence	2 crisprs	cas1,cas2,DEDDh,csa3,cas3,WYL,cas4,DinG,cas5,cas7,cse2gr11,cas8e,cas6e	0	8	2	0

1. NC_016786

CRISPR-Cas detection and classification

Crispr_ID: NC_016786_1

• CRISPR_ID: NC_016786_1
• CRISPR_location: 39596-40654
• CRISPR_type: TypeII
• Repeat_type: NA
• Spacer_info: 16 spacers
• Cas_protein_info: cas2,cas1,cas9

Consensus repeat of NC_016786_1

Consensus_repeat	Method
GAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGC	CRISPRCasFinder
GAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGC	CRT
GAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGC	PILER-CR

spacers of NC_016786_1

>1.1|39632|28|NC_016786|CRISPRCasFinder,CRT
GCGTCGATGATGTCTTTTTCGATGGTGG
>1.2|39696|28|NC_016786|CRISPRCasFinder,CRT
AGGCAGGCAGGAAAGACCGACGCGGTAG
>1.3|39760|28|NC_016786|CRISPRCasFinder,CRT
GTCAAGGCCATCGCAAAAAAGCAGGGTC
>1.4|39824|28|NC_016786|CRISPRCasFinder,CRT
GCTTCGTGGCGCGACCACCGCGGATCAC
>1.5|39888|28|NC_016786|CRISPRCasFinder,CRT
TTAAACTAGACACCAACACCTCAACCCG
>1.6|39952|28|NC_016786|CRISPRCasFinder,CRT
TTACAGCAGGCATGTACGTGGAAGAGGA
>1.7|40016|28|NC_016786|CRISPRCasFinder,CRT
GACGCAATCTCAGCATCAAGTTGCTCTG
>1.8|40080|28|NC_016786|CRISPRCasFinder,CRT
ATAGGATCAACGCCCGTACCAGCGCGGT
>1.9|40144|28|NC_016786|CRISPRCasFinder,CRT,PILER-CR
GGCAGTTTCGCCGCTGTTCTTATCAGCC
>1.10|40208|28|NC_016786|CRISPRCasFinder,CRT,PILER-CR
AATGTTGTATCGTCAAATTCCAAGATCG
>1.11|40272|28|NC_016786|CRISPRCasFinder,CRT,PILER-CR
CGGCGTCGAACGTTTTTCTTCGGTGCCG
>1.12|40336|28|NC_016786|CRISPRCasFinder,CRT,PILER-CR
GGTGGGGTGGGAGTTGCATGCGGATGGT
>1.13|40400|28|NC_016786|CRISPRCasFinder,CRT,PILER-CR
GTCTCGCGAGCAAAGTTACCGGCGGCGT
>1.14|40464|28|NC_016786|CRISPRCasFinder,CRT,PILER-CR
TCATGGACTGGCTAGTGCGTCAGGGTGT
>1.15|40528|28|NC_016786|CRISPRCasFinder,CRT,PILER-CR
CATGCTGACTCCTGCCATCCTCAATCTG
>1.16|40592|27|NC_016786|CRT
CCGCACCAGCGGGGATGAACCGTAGGA

CRISPR arrays and Neighbor proteins around NC_016786_1

CRISPR arrays

The CRISPR arrays of NC_016786_1

>merge|NC_016786|1|39596-40654|CRISPRCasFinder,CRT,PILER-CR
GAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGCGCGTCGATGATGTCTTTTTCGATGGTGGGAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGCAGGCAGGCAGGAAAGACCGACGCGGTAGGAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGCGTCAAGGCCATCGCAAAAAAGCAGGGTCGAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGCGCTTCGTGGCGCGACCACCGCGGATCACGAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGCTTAAACTAGACACCAACACCTCAACCCGGAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGCTTACAGCAGGCATGTACGTGGAAGAGGAGAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGCGACGCAATCTCAGCATCAAGTTGCTCTGGAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGCATAGGATCAACGCCCGTACCAGCGCGGTGAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGCGGCAGTTTCGCCGCTGTTCTTATCAGCCGAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGCAATGTTGTATCGTCAAATTCCAAGATCGGAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGCCGGCGTCGAACGTTTTTCTTCGGTGCCGGAAGTCTATCAGGGTTTTTGAGAACTCAACCCCAGCGGTGGGGTGGGAGTTGCATGCGGATGGTGAAGTCTATCAGGGTTTTTGAGAACTCAACCCCAGCGTCTCGCGAGCAAAGTTACCGGCGGCGTGAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGCTCATGGACTGGCTAGTGCGTCAGGGTGTGAAGTCTATCAGGGTTTTTGAGAACTCAACCCCAGCCATGCTGACTCCTGCCATCCTCAATCTGGAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGCCCGCACCAGCGGGGATGAACCGTAGGAGAAGTTTATCAGGGTTTTTGGGAATGAGGGTGCCTG

>NC_016786|1|1|39596-40591|CRISPRCasFinder
GAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGC	GCGTCGATGATGTCTTTTTCGATGGTGG
GAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGC	AGGCAGGCAGGAAAGACCGACGCGGTAG
GAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGC	GTCAAGGCCATCGCAAAAAAGCAGGGTC
GAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGC	GCTTCGTGGCGCGACCACCGCGGATCAC
GAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGC	TTAAACTAGACACCAACACCTCAACCCG
GAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGC	TTACAGCAGGCATGTACGTGGAAGAGGA
GAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGC	GACGCAATCTCAGCATCAAGTTGCTCTG
GAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGC	ATAGGATCAACGCCCGTACCAGCGCGGT
GAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGC	GGCAGTTTCGCCGCTGTTCTTATCAGCC
GAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGC	AATGTTGTATCGTCAAATTCCAAGATCG
GAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGC	CGGCGTCGAACGTTTTTCTTCGGTGCCG
GAAGTCTATCAGGGTTTTTGAGAACTCAACCCCAGC	GGTGGGGTGGGAGTTGCATGCGGATGGT
GAAGTCTATCAGGGTTTTTGAGAACTCAACCCCAGC	GTCTCGCGAGCAAAGTTACCGGCGGCGT
GAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGC	TCATGGACTGGCTAGTGCGTCAGGGTGT
GAAGTCTATCAGGGTTTTTGAGAACTCAACCCCAGC	CATGCTGACTCCTGCCATCCTCAATCTG
GAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGC

>NC_016786|1|1|39596-40654|CRT
GAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGC	GCGTCGATGATGTCTTTTTCGATGGTGG
GAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGC	AGGCAGGCAGGAAAGACCGACGCGGTAG
GAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGC	GTCAAGGCCATCGCAAAAAAGCAGGGTC
GAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGC	GCTTCGTGGCGCGACCACCGCGGATCAC
GAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGC	TTAAACTAGACACCAACACCTCAACCCG
GAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGC	TTACAGCAGGCATGTACGTGGAAGAGGA
GAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGC	GACGCAATCTCAGCATCAAGTTGCTCTG
GAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGC	ATAGGATCAACGCCCGTACCAGCGCGGT
GAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGC	GGCAGTTTCGCCGCTGTTCTTATCAGCC
GAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGC	AATGTTGTATCGTCAAATTCCAAGATCG
GAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGC	CGGCGTCGAACGTTTTTCTTCGGTGCCG
GAAGTCTATCAGGGTTTTTGAGAACTCAACCCCAGC	GGTGGGGTGGGAGTTGCATGCGGATGGT
GAAGTCTATCAGGGTTTTTGAGAACTCAACCCCAGC	GTCTCGCGAGCAAAGTTACCGGCGGCGT
GAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGC	TCATGGACTGGCTAGTGCGTCAGGGTGT
GAAGTCTATCAGGGTTTTTGAGAACTCAACCCCAGC	CATGCTGACTCCTGCCATCCTCAATCTG
GAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGC	CCGCACCAGCGGGGATGAACCGTAGGA
GAAGTTTATCAGGGTTTTTGGGAATGAGGGTGCCTG

>NC_016786|1|1|40108-40591|PILER-CR
GAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGC	GGCAGTTTCGCCGCTGTTCTTATCAGCC
GAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGC	AATGTTGTATCGTCAAATTCCAAGATCG
GAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGC	CGGCGTCGAACGTTTTTCTTCGGTGCCG
GAAGTCTATCAGGGTTTTTGAGAACTCAACCCCAGC	GGTGGGGTGGGAGTTGCATGCGGATGGT
GAAGTCTATCAGGGTTTTTGAGAACTCAACCCCAGC	GTCTCGCGAGCAAAGTTACCGGCGGCGT
GAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGC	TCATGGACTGGCTAGTGCGTCAGGGTGT
GAAGTCTATCAGGGTTTTTGAGAACTCAACCCCAGC	CATGCTGACTCCTGCCATCCTCAATCTG
GAAGTCTATCAGGGTTTTTGAGAACTGAACCCCAGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016786.1|WP_014301106.1|42944_44966_-|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase	unknown	unknown	gnl|CDD|270916
NC_016786.1|WP_014301095.1|31282_32068_+|thiazole-synthase	unknown	unknown	gnl|CDD|234687
NC_016786.1|WP_014301109.1|49287_50742_-|serine/threonine-protein-phosphatase	unknown	unknown	gnl|CDD|223704
NC_016786.1|WP_014301100.1|38317_39232_+|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl|CDD|187851
NC_016786.1|WP_014301094.1|30008_31097_+|glycine-oxidase-ThiO	unknown	unknown	gnl|CDD|274092
NC_016786.1|WP_014301122.1|59701_59908_-|hypothetical-protein	unknown	unknown	unknown
NC_016786.1|WP_003849887.1|44962_46468_-|serine/threonine-protein-kinase	unknown	unknown	gnl|CDD|270916
NC_016786.1|WP_014301099.1|35059_38314_+|HNH-endonuclease	cas9	cd09643_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl|CDD|375896
NC_016786.1|WP_014301093.1|29343_30012_+|thiamine-phosphate-synthase	unknown	unknown	gnl|CDD|234590
NC_016786.1|WP_014301116.1|55011_56427_-|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|224154
NC_016786.1|WP_041726958.1|31080_31281_+|sulfur-carrier-protein-ThiS	unknown	unknown	gnl|CDD|273754
NC_016786.1|WP_014301108.1|47937_49287_-|FtsW/RodA/SpoVE-family-cell-cycle-protein	unknown	unknown	gnl|CDD|223843
NC_016786.1|WP_014301107.1|46480_47941_-|penicillin-binding-protein-2	unknown	unknown	gnl|CDD|223839
NC_016786.1|WP_003849883.1|42558_42828_-|cell-division-protein-CrgA	unknown	unknown	gnl|CDD|178907
NC_016786.1|WP_014301096.1|32067_33078_+|ThiF-family-adenylyltransferase	unknown	unknown	gnl|CDD|235528
NC_016786.1|WP_014301097.1|33074_33929_+|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	unknown	unknown	gnl|CDD|237797
NC_016786.1|WP_014301092.1|27560_29360_+|phosphomethylpyrimidine-synthase-ThiC	unknown	unknown	gnl|CDD|236451
NC_016786.1|WP_014301111.1|51243_52110_-|DUF3662-and-FHA-domain-containing-protein	unknown	unknown	gnl|CDD|378850
NC_016786.1|WP_014301110.1|50741_51230_-|FHA-domain-containing-protein	unknown	unknown	gnl|CDD|224630
NC_016786.1|WP_003853358.1|39215_39545_+|CRISPR-associated-endonuclease-Cas2	cas2	COG3512_cas2_CAS-II-A:CAS-II-B:CAS-II-C	gnl|CDD|226043

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_016786.1|WP_014301099.1|35059_38314_+|HNH-endonuclease	cas9	cd09643_cas9_CAS-II-A:CAS-II-B:CAS-II-C	4.8e-35	115.9	0.0
NC_016786.1|WP_014301100.1|38317_39232_+|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	1.2e-83	275.2	0.0
NC_016786.1|WP_003853358.1|39215_39545_+|CRISPR-associated-endonuclease-Cas2	cas2	COG3512_cas2_CAS-II-A:CAS-II-B:CAS-II-C	9.1e-23	75.4	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016786.1|WP_014301106.1|42944_44966_-|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	3.76739e-122
NC_016786.1|WP_014301095.1|31282_32068_+|thiazole-synthase	gnl|CDD|234687	PRK00208, thiG, thiazole synthase; Reviewed.	3.51886e-148
NC_016786.1|WP_014301109.1|49287_50742_-|serine/threonine-protein-phosphatase	gnl|CDD|223704	COG0631, PTC1, Serine/threonine protein phosphatase [Signal transduction mechanisms].	5.8507e-73
NC_016786.1|WP_014301100.1|38317_39232_+|type-II-CRISPR-associated-endonuclease-Cas1	gnl|CDD|187851	cd09720, Cas1_II, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer intergration. Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	9.16407e-115
NC_016786.1|WP_014301094.1|30008_31097_+|glycine-oxidase-ThiO	gnl|CDD|274092	TIGR02352, Glycine_oxidase, glycine oxidase ThiO. This family consists of the homotetrameric, FAD-dependent glycine oxidase ThiO, from species such as Bacillus subtilis that use glycine in thiamine biosynthesis. In general, members of this family will not be found in species such as E. coli that instead use tyrosine and the ThiH protein. [Biosynthesis of cofactors, prosthetic groups, and carriers, Thiamine].	5.99192e-125
NC_016786.1|WP_003849887.1|44962_46468_-|serine/threonine-protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.77337e-107
NC_016786.1|WP_014301099.1|35059_38314_+|HNH-endonuclease	gnl|CDD|375896	pfam18470, Cas9_a, Cas9 alpha-helical lobe domain. This is an alpha-helical lobe domain found in Cas9 proteins. Cas9 enzymes adopt a bilobed architecture composed of a nuclease lobe containing juxtaposed RuvC and HNH nuclease domains and a variable alpha-helical lobe likely to be involved in nucleic acid binding. Amino acid residues located in both the nuclease and alpha-helical lobe clefts are highly conserved within type II-A Cas9 proteins.	2.45406e-122
NC_016786.1|WP_014301093.1|29343_30012_+|thiamine-phosphate-synthase	gnl|CDD|234590	PRK00043, thiE, thiamine phosphate synthase.	6.04806e-64
NC_016786.1|WP_014301116.1|55011_56427_-|NAD(P)/FAD-dependent-oxidoreductase	gnl|CDD|224154	COG1233, COG1233, Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism].	1.90067e-78
NC_016786.1|WP_041726958.1|31080_31281_+|sulfur-carrier-protein-ThiS	gnl|CDD|273754	TIGR01683, thiamine_biosynthesis_protein_ThiS, thiamine biosynthesis protein ThiS. This model represents ThiS, a small, ubiquitin-like thiamine biosynthesis protein related to MoaD, a molybdenum cofactor biosynthesis protein. Both proteins are involved in sulfur transfer. ThiS has a conserved Gly-Gly C-terminus that is modified, in reactions requiring ThiI, ThiF, IscS, and a sulfur atom from Cys, into the thiocarboxylate that provides the sulfur for thiazole biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Thiamine].	4.02771e-21
NC_016786.1|WP_014301108.1|47937_49287_-|FtsW/RodA/SpoVE-family-cell-cycle-protein	gnl|CDD|223843	COG0772, FtsW, Bacterial cell division membrane protein [Cell division and chromosome partitioning].	2.78845e-82
NC_016786.1|WP_014301107.1|46480_47941_-|penicillin-binding-protein-2	gnl|CDD|223839	COG0768, FtsI, Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane].	1.0564e-81
NC_016786.1|WP_003849883.1|42558_42828_-|cell-division-protein-CrgA	gnl|CDD|178907	PRK00159, PRK00159, putative septation inhibitor protein; Reviewed.	2.52021e-46
NC_016786.1|WP_014301096.1|32067_33078_+|ThiF-family-adenylyltransferase	gnl|CDD|235528	PRK05600, PRK05600, thiamine biosynthesis protein ThiF; Validated.	0
NC_016786.1|WP_014301097.1|33074_33929_+|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	gnl|CDD|237797	PRK14713, PRK14713, bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase.	1.88044e-110
NC_016786.1|WP_014301092.1|27560_29360_+|phosphomethylpyrimidine-synthase-ThiC	gnl|CDD|236451	PRK09284, PRK09284, thiamine biosynthesis protein ThiC; Provisional.	0
NC_016786.1|WP_014301111.1|51243_52110_-|DUF3662-and-FHA-domain-containing-protein	gnl|CDD|378850	pfam12401, DUF3662, Protein of unknown function (DUF2662). This domain family is found in bacteria, and is approximately 120 amino acids in length. The family is found in association with pfam00498.	5.57786e-42
NC_016786.1|WP_014301110.1|50741_51230_-|FHA-domain-containing-protein	gnl|CDD|224630	COG1716, COG1716, FOG: FHA domain [Signal transduction mechanisms].	1.15439e-18
NC_016786.1|WP_003853358.1|39215_39545_+|CRISPR-associated-endonuclease-Cas2	gnl|CDD|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	1.12332e-19

Protein sequences

>NC_016786.1|WP_003853358.1|39215_39545_+|CRISPR-associated-endonuclease-Cas2
MPKKGSDPVWCVVMFDLPVKTKTQRKQATAFRQNLLDLGFCMAQLSVYVQYLPLAAKLSNLVKLIKEKLPPGGDVRILSVSDIQWSKMIRFSSSAEVSGEEKPDQLAIF
>NC_016786.1|WP_014301100.1|38317_39232_+|type-II-CRISPR-associated-endonuclease-Cas1
MNPGWRVVDLIDFDGKVSYQRGQLAITSDSGELRATLPLAQIAVVLIGNKIIISGAVLVKLSEYDIAVLVCDWRRVPVAGSFSWNEHTRIAARQRAQASLSLPRQKSAWAQIIKAKILGQARTAAQLGFDATDLKNLARAVRSGDVDNREAMAAKRYWEIISTEDDFRRLPGLAATGWNGALDYAYTVLRGHGMRAICSAGLVGTLGVFHHGRGNQFALVDDLIEPFRPAIDYAVFSIVSNAQELDKETKRQLVAAVEEPFNSAGQSIPTVFTAFAQQYGRYVEGDVEKLVPPIWEGPFDAEER
>NC_016786.1|WP_014301099.1|35059_38314_+|HNH-endonuclease
MKYHVGIDVGTFSVGLAAIEVDDAGMPIKTLSLVSHIHDSGLDPDKIKSAVTRLASSGIARRTRRLYRRKRRRLQQLDKFIQRQGWPVIELEDYSDPLYPWKVRAELAASYIADEKERGEKLSVALRHIARHRGWRNPYAKVSSLYLPDEPSDAFKAIREEIKRASGQPVPETATVGQMVTLCELGTLKLRGEGGVLSARLQQSDHAREIQEICRMQEIGQELYRKIIDVVFAAESPKGSASSRVGKDPLQPGKNRALKASDAFQRYRIAALIGNLRVRVDGEKRILSVEEKNLVFDHLVNLAPKKEPEWVTIAEILGIDRGQLIGTATMTDDGERAGARPPTHDTNRSIVNSRIAPLVDWWKTASALEQHAMVKALSNAEVDDFDSPEGAKVQAFFADLDDDVHAKLDSLHLPVGRAAYSEDTLVRLTRRMLADGVDLYTARLQEFGIEPSWTPPAPRIGEPVGNPAVDRVLKTVSRWLKSATKTWGAPERVIIEHVREGFVTEKRAREMDGDMRRRAARNAKLFQEMQEKLNVQGKPSRADLWRYQSVQRQNCQCAYCGSPITFSNSEMDHIVPRAGQGSTNTRENLVAVCHRCNQSKGNTPFAIWAKNTSIEGVSVKEAVERTRHWVTDTGMRSTDFKKFTKAVVERFQRATMDEEIDARSMESVAWMANELRSRVAQHFASHGTTVRVYRGSLTAEARRASGISGKLEFLDGVGKSRLDRRHHAIDAAVIAFTSDYVAETLAVRSNLKQSQAHRQEAPQWREFTGKDAEHRAAWRVWCQKMEKLSALLTEDLRDDRVVVMSNVRLRLGNGSAHEETIGKLSKVKLGSQLSVSDIDKASSEALWCALTREPDFDPKDGLPANPERHIRVNGTHVYAGDNIGLFPVSAGSIALRGGYAELGSSFHHARVYKITSGKKPAFAMLRVYTIDLLPYRNQDLFSVELKPQTMSMRQAEKKLRDALATGNAEYLGWLVVDDELVVDTSKIATDQVKAVEAELGTIRRWRVDGFFGDTRLRLRPLQMSKEGIKKESAPELSKIIDRPGWLPAVNKLFSEGNVTVVRRDSLGRVRLESTAHLPVTWKVQ
>NC_016786.1|WP_014301097.1|33074_33929_+|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase
MTPHILTIAGSDPSGGAGIQADLKSIMAAGGYGMAAITALTAQNTCGVTAIHTPPTEFLSEQLRAISDDITIHAIKIGMIGSSDAATAIATWLDQLHHTPIVVLDPVMVATSGSVLGERHYFEPLLHHATVITPNLPELAVLANNHDPEQAEHVARSLAEQYDCAVLLKGGHRHGTDDLGNTWITASGPQFHAPSPRIHTTNTHGTGCSLSSALATRLAIEPPEPALHWATTWLNGAIAHGSDLNVGHGNGPVDHSYRLEEYSANCNTHPKNSRRATFNMAPQL
>NC_016786.1|WP_014301096.1|32067_33078_+|ThiF-family-adenylyltransferase
MLDELERQRVARQLRLPGFGIEQQEKLNKGRVLVIGVGGLGSPALQSLAAAGVGSIRLVDNDTVDVSNIQRQILFGVGDVGRSKVHVAAERLRAIQPGIRIDARTERLTAHNAHELAEGCDVILDGSDTFATKFLCGDLAEITGIPLVWGSVLQFEGHMGVFTREVGLRDLFPEAPTQGLNCADAGVLGATTAVIANLMATETIKILAGIGTVQPGAITTYNALTSTFRTYTVGRDPLRPAARTLHTWTLPNEYELIDVREPHEIEHTPSGAHITLPQSMWDDTTAIHHALDHITTDNVVVVCASGIRSAAFIEQFAHLNPHLTFHNVPSGINELP
>NC_016786.1|WP_014301095.1|31282_32068_+|thiazole-synthase
MLTIADRSFQSHLIMGTGGASSFDTLEKSLIASGTELTTVAMRRHAAHTGAHGESVFELMQRLNITPLPNTAGCRTARDAILTAQLAREALDTSWIKVEVIADDTTLLPDVLELIDATETLTNDGFTVLAYTSDDPVVAQRLEDAGAAAVMPLGSPIGTGLGILNPHNIELICSRATVPVLLDAGIGTASDATLAMELGCSGVLLASAINRCINPIAMATAMKHAVEAGRLAREAGRIPRREHAVASSSFEGLASWADEVL
>NC_016786.1|WP_041726958.1|31080_31281_+|sulfur-carrier-protein-ThiS
MDIYINDTPTTIETPQLTDIISNHCNGIRPGIAVAINQRVIPRSQWDTTTVTAGDHLDILTAVQGG
>NC_016786.1|WP_014301094.1|30008_31097_+|glycine-oxidase-ThiO
MKIAVVGGGIVGLSTAFELSTRGHSVHVFDLNPASGASHFAGGMLAPAAEVQFQQDPLFPLMKCAGKLWPDMVRRVAQHTSLPTGYRTEGTLVVAADCADAEHLKQLRATQEAAGMDVRPITTRQARGLEPALGPRLSAAVHIPNDTQVAPRVFLTALLDALDDCGVEVIKEEITDLEPLYQQFEVVVLAAGLGAQHLSPIPLALRPVRGDILRVQTEPGAVNMVVRGWVNDRPIYIIPRANGEIAIGATSREDERDLPSVEGIYDLLRDAVRVVPGIVDSSLIEANVGVRPGTPDDLPYLGWASDRLIISTGYFRHGILLSALGAHVTACLIDGTDPGIDLTACAPDRHHNERGETHGHLH
>NC_016786.1|WP_014301093.1|29343_30012_+|thiamine-phosphate-synthase
MLPTPRWGRDFDPRCYFVTGTGSVDHIVDVARQAARAGAGLIQVRSKPIAARDLYILGREVARAVAEVNPGTRVLIDDRVDVALALMNNGEHIHGVHVGQDDLPVRHVRALLGDNAIIGLTTGTLELVRASRQVAEVIDYIGAGPFRPTPTKDSGRAPVGLAGYPPLVAESLVPVVAIGDVRPEDAADLAATGVAGVAIVRALMNSQDVAADVKLVLKGFTQ
>NC_016786.1|WP_014301092.1|27560_29360_+|phosphomethylpyrimidine-synthase-ThiC
MSAASANSVTNPSAWENSEIHPKHSYSPIVSGDLEVPETEIQLDDSPTGPNDPVRIYRTRGPECDPTVGLKPLRAQWIDSREDTEEYAGRERNLADDGRSAQRRGAASLEWKGVKPTPRRAKQGKRVTQMHYARQGIITKEMEFVALREHMDPEFVRSEIARGRAIIPNNINHPESEPMIIGRKFLTKINANIGNSAVTSSIEEEVSKLRWSTRWGADTVMDLSTGDDIHTTREWIIRNSPVPIGTVPIYQALEKVNGVAEDLTWEIFRDTVIEQCEQGVDYMTIHAGVLLAYIPLTTKRVTGIVSRGGSIMAGWCLAHHKESFLYEHFDELCEIFAQYDVAFSLGDGLRPGSVADANDAAQFAELKTIGELARRAWEYDVQVMIEGPGHVPLNMVQENNELEQKWAHDAPFYTLGPLVTDIAPGYDHITSAIGAAHIAMGGTAMLCYVTPKEHLGLPNRDDVKTGVITYKLAAHAADVAKGHPDARAWDDAMSKARFEFRWHDQFALSLDPDTAIAYHDETLPAEPAKTAHFCSMCGPKFCSMRISQDIRDMFADKIADLGIPQVGGDAEAGMAAKSEEFVAQGSQLYSEVRDNAAHA
>NC_016786.1|WP_003849883.1|42558_42828_-|cell-division-protein-CrgA
MPKSKINHSSTAYTAGSTANRTPVKINSTGTPLWYKIIMFGLILAGLLWLIVNYLAGQDISFMTELGPWNYGIGFGLFIIGLLMTMGWR
>NC_016786.1|WP_014301106.1|42944_44966_-|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase
MTDIVLADRYRLGDVIGTGGMSEVYEATDVLLGRKVAVKMLRADLARDVNFRERFRREAQNSGKLNHPAIVAVYDTGETPRAGLNTPYIVMELVNGRTLRDIVREDGPLTPSQAAHTLIPVCHALQVSHDAGIIHRDIKPANVMITNTGAVKIMDFGIARALDDATSAMTQTSAVIGTAQYLSPEQARGKLADARSDVYALGCVLYETLTGKPPFEGETPFAVAYQHVQEDPVKPSEYIADLSPTAAINVDAVVLTAMAKHPGDRYQTAQEMCADLERLERNAVTDAARHYVTPTSFATQDPASTTVVPVTQVTELDHAEAGAGIGAGVVPAGAVAGSAAVAGAGGAHAAPRSSNRGLRILAAILAVLVLAVGAGFAIDHFGGGPFSQRSTVTIPKLQNSTQQDAVNQLEKLGLQVNVIEEPNPDIPRGKVIRTNPTDGSNVQRNSTVRLTISSGKEITEVPDLSGKNTADAVKILEAAGLLLDPTVREDSSDTVPKGEIIEVSPAAGSQVSRGSKVSITVSTGVETVRVPVITGMKWDQAEGNLTSLGFKPEVVRVDSVEPAGTVVAVPDEGAEVPKGSSVTVQISNGAMFTVPEITRQTIGDAVRILHDAGWKGNASRLIQAAKVPTVAVTDQNLIASQLPTPGTTLRKDAPIEIRLYEFNLAALVPPAQH
>NC_016786.1|WP_003849887.1|44962_46468_-|serine/threonine-protein-kinase
MTQSQSPDPALQALVGSDYALQWVVGNGGMSTVWLADDLRNQREVAIKVLRPEFSDNEEFLSRFRNEALASEHIDSDNVVRTYDYREVTDDMGRTLCFIVMEYVRGESLADMLARKGRLEEDLALDVLEQAAHGLSIIHRMGMVHRDIKPGNLLITQNGQVKITDFGIAKAAAAVPLTRTGMVVGTAQYVSPEQAQGRDVTAATDVYSLGVVGYEMLVGQRPFTGDSSVSVAIAHINQAPPAMPTSVSAPARELIGIALRKDPAHRYADGNELALAVSATRMGQRPPQPKSAPLQHIAPQPAPTESTYALGATAQPTTVIPATGQVPAAPAAAAYPASTVIPAGTPRQEPEKQSSGWGAGIVVGALAALLLGTAAWAASQGMFDDLFDKTSQSSEPSVPPPPVTATVTETPTPQITTVVPEPLPTSRPEPTPSETKRTPDESHPTSDHQLPSVRPSHNGRPSSQAPQAPTQDADQPAESPAPDTLDSLIENLNKLNQGGAQ
>NC_016786.1|WP_014301107.1|46480_47941_-|penicillin-binding-protein-2
MNRSIRFTSVFALLLILILLVNLTIIQGFSQEKYAHNALNRRGFIELKSQARGQISTGGQVLAESYQDEEGFYQRRYVTNPAIYGPIEGYLSDIYGASGMESNLNGVLSGTDSSVSVRRWTDELLGRKHSGANVELTLLPQVQEVAYNQMANAGYEGAVVAIKPSTGEILAMASTPSYDPSAIVNPDTAEQTWAALNADPGNPLLNHATQETLPPGSTFKVITTAAGLNAGYGPGSMLTGQDRITLPDGITTLENYAGQTCAGSQNVTLATAFQYSCNTAFVQMGIDVGKEKFDEAAHAFGVNDRYDLGVDMAPGTIGDVSDPSARGQSSIGQRDVAMSVLHNAVVAATVANGGKRMEPHLVSRIVGQDLKVIKETKPHQINEAVTPEVAATLTDLMRLSERHTAGYTGADIASKTGTAEHGEDSRNSNPHAWYIAFGPSANADVAVAVVVKNGGDAGQAATGGSVAAPIGRAVIAAAQAALAARG
>NC_016786.1|WP_014301108.1|47937_49287_-|FtsW/RodA/SpoVE-family-cell-cycle-protein
MTFLRRITARPVEFGLLVMATLLIAVTLINLNMAQGLSVTSETLWVIGGFIGVFTIAHLALCFTAPHADQVMLPVASVLNGLGLVMVYRIDLARDTALASRQVIWTLVGILLMIAVLVFIRDHRMLSRYSYVLGLLGLILLALPMVWPTKMNADANIWISIGPFSVQPGEFSKILLLIFFAQLLVNKRALFNVAGYRFLGLEFPRLRDLGPILGVWAFAILVMAGENDFGPALLLFSTVLGMLYLATNRVSWLIIGAALVAVGGTALYQISSKIQSRVTNFINPLDNFNGTGYQLSQSLFGLSSGGVAGAGLGLGHPELIPVAESDFILAAVGEELGFIGLAAVLVLFAIFITRGLRTALRARDSYGKLMAAGLSLTLAIQVFVVTAGITALMPMTGLTTPFMSQGGSSLMANYILLGLILRISHSTQAAANDVVSMDEQAARGQEAHR
>NC_016786.1|WP_014301109.1|49287_50742_-|serine/threonine-protein-phosphatase
MLRLNYAAASDRGLVRGNNEDSAYAGPHLIALADGMGGHAAGEVASQLMINHLMRLDADVDDNDMLALLASVADDANRAIAQGVRDVPETDGMGTTLTALMFNGADLAMCHVGDSRGYRLRDGALEQITVDDTYVQSLVDKGQLAPEDVSTHPQRSMILKAYAGRPVEPTLKMIDIRPGDRFLLCSDGLSDPVTHSTIETTLQQGTPQEAARRLVDLALRSGGPDNVTVVVADVVEADGSDESAAAASLPVTPLTVGALNSGMPEDPRPDTAAGRAAMAITQRQPQVILPDPEPVKEATPSPLRRMVAVISALVVLAVLISAGWWGSSMVKNNYYVTTADSDSAQGALVIENGIDVSLLGKSLHSTYQFACLSPEGDLTFVDSADAENSCHRFRLSDLKESARGQVSTLPDGSYDEVQQQLQRLAEQTLPACITRQAAQPKDKDQKKPAAPSSAAPTTTKAASPSSTGSPDDLSTPGETCREVK
>NC_016786.1|WP_014301110.1|50741_51230_-|FHA-domain-containing-protein
MESVIVFLLRIALLVLLWLLILLALYIQRKDAKSAAQTMVAPQAVTGPGVSSASSPLKKVSRRGGAPQQIVVVEGPLTGSSMQLDSLTEITLGRSKDCDFVVGDDYASARHARLIKRGSEWFAEDLDSRNGTYVGGYRIDQPEKVSAGSDIKIGRTTVRLVA
>NC_016786.1|WP_014301111.1|51243_52110_-|DUF3662-and-FHA-domain-containing-protein
MSIMGKVAKLDSAMQRGLDNSFAFVFGGKLVPAEIEELLKQEVQDNIVRAYEGGVESPNVFRVRVSRKDAQNLAQRYPSLADDFADRLSRYTRNQGWSTEGPVVVTIAADSGLRTGQLHASSAFDPVPQEYSHFIGVEDDVAAAAPTNDESNYESESGMNSYDADPRTEYMTAQAPDAIYTEVPVPEPKATPTVSLLLQDGSSRTYLVEEGSNIIGRSNEAHFRLPDTGVSRQHAEITWNGHDAILTDLKSTNGTTVNDTPVENWLLEDGDVITVGHSHIEVRIVEPN
>NC_016786.1|WP_014301116.1|55011_56427_-|NAD(P)/FAD-dependent-oxidoreductase
MKAAVVGSGPNGLAAAVVLAQYGMEVTVFEADNTVGGGMRSHEGLRSGVIHDMCSAVHPLAVASPFFREAKLDRHGLDFAFPKLDLAHPLDDGSTGLLYRNLNQTTEKMGKDELLWRATFGPLAKHFNSIASDTLGPMLRVPRSAMWTGLFGFNAALPASLSALRWREESTRALFAGIAAHAFSRLDTPLSSSAGTLLIAAAHNTGWPVAVGGSQSIVKAFLAELAQLRVTVMCGTRIDSFQQINDFDVVMLDTTPQNALRILGDRLPKRIQKAYSRFSHGPGAFKVDFLIDGDIPWSSKALRQAGTVHLGGTFAEIAEAEKGIVAGKMPQNPFVLLGQQYLADPSRSDGRLNPVWAYAHVPNGFDADATELIVRQIERFAPNFRDTIVDSVSFSTEEMQRYNANYVGGDIIGGASGVRQLIARPILSPDPYYTGVPGVYICSSSTPPGAGVHGMCGKNAAESALKQLQQR
>NC_016786.1|WP_014301122.1|59701_59908_-|hypothetical-protein
MKPSDISTRLNVGTSVVYRIGIELGLWQRNPHGRRASATSRRCEYLMLRFGAMSRKDAAKGLFRFWGA

Crispr_ID: NC_016786_2

• CRISPR_ID: NC_016786_2
• CRISPR_location: 2250293-2250565
• CRISPR_type: TypeI-E
• Repeat_type: I-C,I-E,II-B
• Spacer_info: 4 spacers
• Cas_protein_info: cas2,cas1,cas3,cas6e,cas8e,cse2gr11,cas7,cas5

Consensus repeat of NC_016786_2

Consensus_repeat	Method
GTCTTCTCCGCACACGCGGAGGTATTTCC	PILER-CR
GTCTTCTCCGCACACGCGGAGGTATTTCC	CRISPRCasFinder
GTCTTCTCCGCACACGCGGAGGTATTTCC	CRT

spacers of NC_016786_2

>2.1|2250322|32|NC_016786|PILER-CR,CRISPRCasFinder,CRT
GGACGGTACGCAAATACTTACTGCCTTAATGA
>2.2|2250383|32|NC_016786|PILER-CR,CRISPRCasFinder,CRT
CGCCCTATCGTATGCGCGCTTCGCGGCCATGT
>2.3|2250444|32|NC_016786|PILER-CR,CRISPRCasFinder,CRT
GAAACCGAAACCCGACTTGAAAGAGGCGAAGA
>2.4|2250505|32|NC_016786|PILER-CR,CRISPRCasFinder,CRT
ATCCGCTCATCTAGGGTTACGCGGGTGGGCAG

CRISPR arrays and Neighbor proteins around NC_016786_2

CRISPR arrays

The CRISPR arrays of NC_016786_2

>merge|NC_016786|2|2250293-2250565|PILER-CR,CRISPRCasFinder,CRT
GTCTTCTCCGCACACGCGGAGGTATTTCCGGACGGTACGCAAATACTTACTGCCTTAATGAGTCTTCTCCGCACACGCGGAGGTATTTCCCGCCCTATCGTATGCGCGCTTCGCGGCCATGTGTCTTCTCCGCACACGCGGAGGTATTTCCGAAACCGAAACCCGACTTGAAAGAGGCGAAGAGTCTTCTCCGCACACGCGGAGGTATTTCCATCCGCTCATCTAGGGTTACGCGGGTGGGCAGGTCTTCTCCGCACACGCGGAGGTATTTCC

>NC_016786|2|2|2250293-2250565|PILER-CR
GTCTTCTCCGCACACGCGGAGGTATTTCC	GGACGGTACGCAAATACTTACTGCCTTAATGA
GTCTTCTCCGCACACGCGGAGGTATTTCC	CGCCCTATCGTATGCGCGCTTCGCGGCCATGT
GTCTTCTCCGCACACGCGGAGGTATTTCC	GAAACCGAAACCCGACTTGAAAGAGGCGAAGA
GTCTTCTCCGCACACGCGGAGGTATTTCC	ATCCGCTCATCTAGGGTTACGCGGGTGGGCAG
GTCTTCTCCGCACACGCGGAGGTATTTCC

>NC_016786|2|2|2250293-2250565|CRISPRCasFinder
GTCTTCTCCGCACACGCGGAGGTATTTCC	GGACGGTACGCAAATACTTACTGCCTTAATGA
GTCTTCTCCGCACACGCGGAGGTATTTCC	CGCCCTATCGTATGCGCGCTTCGCGGCCATGT
GTCTTCTCCGCACACGCGGAGGTATTTCC	GAAACCGAAACCCGACTTGAAAGAGGCGAAGA
GTCTTCTCCGCACACGCGGAGGTATTTCC	ATCCGCTCATCTAGGGTTACGCGGGTGGGCAG
GTCTTCTCCGCACACGCGGAGGTATTTCC

>NC_016786|2|2|2250293-2250565|CRT
GTCTTCTCCGCACACGCGGAGGTATTTCC	GGACGGTACGCAAATACTTACTGCCTTAATGA
GTCTTCTCCGCACACGCGGAGGTATTTCC	CGCCCTATCGTATGCGCGCTTCGCGGCCATGT
GTCTTCTCCGCACACGCGGAGGTATTTCC	GAAACCGAAACCCGACTTGAAAGAGGCGAAGA
GTCTTCTCCGCACACGCGGAGGTATTTCC	ATCCGCTCATCTAGGGTTACGCGGGTGGGCAG
GTCTTCTCCGCACACGCGGAGGTATTTCC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_016786.1|WP_014302525.1|2251353_2251551_+|hypothetical-protein	unknown	unknown	unknown
NC_016786.1|WP_010935664.1|2242068_2243127_-|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	cas7	pfam09344_cas7_CAS-I-E	gnl|CDD|378153
NC_016786.1|WP_014302532.1|2255787_2256744_-|SpaH-fimbrial-biogenesis-class-C-sortase-SrtD	unknown	unknown	gnl|CDD|320676
NC_016786.1|WP_014302523.1|2246367_2248998_+|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl|CDD|182031
NC_016786.1|WP_010935675.1|2253136_2253412_+|hypothetical-protein	unknown	unknown	unknown
NC_016786.1|WP_010935661.1|2238673_2238949_-|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|213181
NC_016786.1|WP_014302528.1|2253567_2253717_+|hypothetical-protein	unknown	unknown	unknown
NC_016786.1|WP_014308874.1|2253874_2254684_-|SpaH-fimbrial-minor-subunit-SpaI	unknown	unknown	gnl|CDD|380024
NC_016786.1|WP_158308708.1|2250587_2250761_+|hypothetical-protein	unknown	unknown	unknown
NC_016786.1|WP_014302526.1|2252053_2252731_+|hypothetical-protein	unknown	unknown	unknown
NC_016786.1|WP_014302521.1|2243182_2243767_-|type-I-E-CRISPR-associated-protein-Cse2/CasB	cse2gr11	mkCas0096_cse2gr11_CAS-I-E	gnl|CDD|274193
NC_016786.1|WP_010935671.1|2250819_2251335_+|single-stranded-DNA-binding-protein	unknown	unknown	gnl|CDD|236092
NC_016786.1|WP_014309675.1|2254757_2255804_-|SpaH-fimbrial-biogenesis-class-C-sortase-SrtE	unknown	unknown	gnl|CDD|320676
NC_016786.1|WP_010935669.1|2248999_2249959_+|type-I-E-CRISPR-associated-endonuclease-Cas1	cas1	cd09719_cas1_CAS-I-E	gnl|CDD|274693
NC_016786.1|WP_014302527.1|2252757_2253147_+|hypothetical-protein	unknown	unknown	unknown
NC_016786.1|WP_010935670.1|2249959_2250274_+|type-I-E-CRISPR-associated-endoribonuclease-Cas2	cas2	pfam09707_cas2_CAS-I-E	gnl|CDD|378244
NC_016786.1|WP_014302520.1|2239418_2241239_+|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl|CDD|227766
NC_016786.1|WP_010935663.1|2241347_2242076_-|type-I-E-CRISPR-associated-protein-Cas5/CasD	cas5	cd09645_cas5_CAS-I-E	gnl|CDD|187776
NC_016786.1|WP_010935667.1|2245681_2246368_+|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	cas6e	cd09727_cas6e_CAS-I-E	gnl|CDD|187858
NC_016786.1|WP_014302522.1|2243759_2245316_-|CRISPR-associated-protein	cas8e	cls000721_cas8e_CAS-I-E	gnl|CDD|378189

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_016786.1|WP_010935669.1|2248999_2249959_+|type-I-E-CRISPR-associated-endonuclease-Cas1	cas1	cd09719_cas1_CAS-I-E	7e-68	223.4	0.0
NC_016786.1|WP_010935670.1|2249959_2250274_+|type-I-E-CRISPR-associated-endoribonuclease-Cas2	cas2	pfam09707_cas2_CAS-I-E	1.1e-27	90.7	0.0
NC_016786.1|WP_014302523.1|2246367_2248998_+|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	4e-60	198.6	0.0
NC_016786.1|WP_010935663.1|2241347_2242076_-|type-I-E-CRISPR-associated-protein-Cas5/CasD	cas5	cd09645_cas5_CAS-I-E	2.6e-43	142.6	0.0
NC_016786.1|WP_010935667.1|2245681_2246368_+|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	cas6e	cd09727_cas6e_CAS-I-E	1.3e-41	137.7	0.0
NC_016786.1|WP_010935664.1|2242068_2243127_-|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	cas7	pfam09344_cas7_CAS-I-E	2.5e-95	314.8	0.0
NC_016786.1|WP_014302521.1|2243182_2243767_-|type-I-E-CRISPR-associated-protein-Cse2/CasB	cse2gr11	mkCas0096_cse2gr11_CAS-I-E	3.1e-82	269.9	0.1
NC_016786.1|WP_014302522.1|2243759_2245316_-|CRISPR-associated-protein	cas8e	cls000721_cas8e_CAS-I-E	0	1249.6	0.9

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_016786.1|WP_010935664.1|2242068_2243127_-|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	gnl|CDD|378153	pfam09344, Cas_CT1975, CT1975-like protein. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is represented by CT1975 of Chlorobium tepidum.	3.14006e-110
NC_016786.1|WP_014302523.1|2246367_2248998_+|CRISPR-associated-helicase/endonuclease-Cas3	gnl|CDD|182031	PRK09694, PRK09694, CRISPR-associated helicase/endonuclease Cas3.	2.53549e-61
NC_016786.1|WP_010935661.1|2238673_2238949_-|ATP-binding-cassette-domain-containing-protein	gnl|CDD|213181	cd03214, ABC_Iron-Siderophores_B12_Hemin, ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins. ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC transporter mediating vitamin B12 uptake. The two ATP-binding cassettes (BtuD) are in close contact with each other, as are the two membrane-spanning subunits (BtuC); this arrangement is distinct from that observed for the E. coli lipid flippase MsbA. The BtuC subunits provide 20 transmembrane helices grouped around a translocation pathway that is closed to the cytoplasm by a gate region, whereas the dimer arrangement of the BtuD subunits resembles the ATP-bound form of the Rad50 DNA repair enzyme. A prominent cytoplasmic loop of BtuC forms the contact region with the ATP-binding cassette and represent a conserved motif among the ABC transporters.	9.10266e-23
NC_016786.1|WP_014308874.1|2253874_2254684_-|SpaH-fimbrial-minor-subunit-SpaI	gnl|CDD|380024	pfam17802, SpaA, Prealbumin-like fold domain. This entry contains a prealbumin-like domain from a wide variety of bacterial surface proteins. This entry corresponds to domain 1 and domain 3 of SpaA from Corynebacterium diphtheriae. Some members of this family contain an isopeptide bond.	2.52575e-05
NC_016786.1|WP_014302532.1|2255787_2256744_-|SpaH-fimbrial-biogenesis-class-C-sortase-SrtD	gnl|CDD|320676	cd05827, Sortase_C, Sortase domain found in class C sortases. Class C sortases are membrane-bound cysteine transpeptidases broadly distributed in Gram-positive bacteria (mainly present in Firmicutes and Actinobacteria). They function as pilin polymerases responsible for the assembly of pili, which are multi-subunit hair-like fibres that extend from the cell surface to promote microbial adhesion and biofilm formation. First, one or more class C sortases form the long thin shaft of the pilus through linking together pilin subunits via isopeptide bonds. The base of the pilus is then anchored to the cell wall by a housekeeping sortase or, in some cases, the class C sortase itself. Depending upon the organism both the number and type of sortase enzymes involved varies, and in some cases, accessory factors appear to be needed. In three-component spaA pilus from Corynebacterium diphtheriae, the prototypical class C sortase (named Cd-SrtA) catalyzes polymerization of the SpaA-type pilus, consisting of the shaft pilin SpaA, tip pilin SpaC and minor pilin SpaB. The pilus shaft is then attached to the cell wall by a housekeeping class E sortase, Cd-SrtF. In the absence of Cd-SrtF, Cd-SrtA attaches the pilus to the cell wall, albeit at a reduced rate. Cd-SrtA can recognize two distinct sorting signals (LPLTG in SpaA and SpaC, and LAFTG in SpaB) and it can employ lysine residues that originate from different proteins (either Lys190 within the pilin motif of SpaA or Lys139 in SpaB). However, Cd-SrtA cannot be able to polymerize the major pilin subunit SpaH, even though it contains LPLTG motif. In two-component pili of prototypical Bacillus cereus, the class C sortase (named Bc-SrtD) cleaves related sorting signals within a major pilin protein BcpA (LPVTG) and a minor tip pilin BcpB (IPNTG), and catalyzes a transpeptidation that joins the threonine residues in each signal to the side-chain of Lys162 in BcpA (located within a pilin motif). Unlike the SpaA pilus in C. diphtheriae, in B. cereus Bc-SrtD is unable to covalently attach the pilus to the cell wall without the help of the housekeeping sortase.	7.13957e-80
NC_016786.1|WP_014302521.1|2243182_2243767_-|type-I-E-CRISPR-associated-protein-Cse2/CasB	gnl|CDD|274193	TIGR02548, CRISPR_system_Cascade_subunit_CasB, CRISPR type I-E/ECOLI-associated protein CasB/Cse2. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This model family is found in Ecoli subtype CRISPR/Cas regions of many bacteria, most of which are mesophiles, and not in Archaea. It was designated Cse2 originally, and renamed CasB based on its characterization in the CASCADE complex.	1.24993e-36
NC_016786.1|WP_010935671.1|2250819_2251335_+|single-stranded-DNA-binding-protein	gnl|CDD|236092	PRK07772, PRK07772, single-stranded DNA-binding protein; Provisional.	9.01045e-84
NC_016786.1|WP_014309675.1|2254757_2255804_-|SpaH-fimbrial-biogenesis-class-C-sortase-SrtE	gnl|CDD|320676	cd05827, Sortase_C, Sortase domain found in class C sortases. Class C sortases are membrane-bound cysteine transpeptidases broadly distributed in Gram-positive bacteria (mainly present in Firmicutes and Actinobacteria). They function as pilin polymerases responsible for the assembly of pili, which are multi-subunit hair-like fibres that extend from the cell surface to promote microbial adhesion and biofilm formation. First, one or more class C sortases form the long thin shaft of the pilus through linking together pilin subunits via isopeptide bonds. The base of the pilus is then anchored to the cell wall by a housekeeping sortase or, in some cases, the class C sortase itself. Depending upon the organism both the number and type of sortase enzymes involved varies, and in some cases, accessory factors appear to be needed. In three-component spaA pilus from Corynebacterium diphtheriae, the prototypical class C sortase (named Cd-SrtA) catalyzes polymerization of the SpaA-type pilus, consisting of the shaft pilin SpaA, tip pilin SpaC and minor pilin SpaB. The pilus shaft is then attached to the cell wall by a housekeeping class E sortase, Cd-SrtF. In the absence of Cd-SrtF, Cd-SrtA attaches the pilus to the cell wall, albeit at a reduced rate. Cd-SrtA can recognize two distinct sorting signals (LPLTG in SpaA and SpaC, and LAFTG in SpaB) and it can employ lysine residues that originate from different proteins (either Lys190 within the pilin motif of SpaA or Lys139 in SpaB). However, Cd-SrtA cannot be able to polymerize the major pilin subunit SpaH, even though it contains LPLTG motif. In two-component pili of prototypical Bacillus cereus, the class C sortase (named Bc-SrtD) cleaves related sorting signals within a major pilin protein BcpA (LPVTG) and a minor tip pilin BcpB (IPNTG), and catalyzes a transpeptidation that joins the threonine residues in each signal to the side-chain of Lys162 in BcpA (located within a pilin motif). Unlike the SpaA pilus in C. diphtheriae, in B. cereus Bc-SrtD is unable to covalently attach the pilus to the cell wall without the help of the housekeeping sortase.	9.64956e-78
NC_016786.1|WP_010935669.1|2248999_2249959_+|type-I-E-CRISPR-associated-endonuclease-Cas1	gnl|CDD|274693	TIGR03638, cas1_ECOLI, CRISPR-associated endonuclease Cas1, subtype I-E/ECOLI. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the ECOLI subtype of CRISPR/Cas system.	2.24064e-73
NC_016786.1|WP_010935670.1|2249959_2250274_+|type-I-E-CRISPR-associated-endoribonuclease-Cas2	gnl|CDD|378244	pfam09707, Cas_Cas2CT1978, CRISPR-associated protein (Cas_Cas2CT1978). This entry represents a minor branch of the Cas2 family of CRISPR-associated protein which are found in IPR003799. Cas proteins are found adjacent to a characteristic short, palindromic repeat cluster termed CRISPR, a probable mobile DNA element.	2.16845e-29
NC_016786.1|WP_014302520.1|2239418_2241239_+|N-acetylmuramoyl-L-alanine-amidase	gnl|CDD|227766	COG5479, COG5479, Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane].	7.70094e-40
NC_016786.1|WP_010935663.1|2241347_2242076_-|type-I-E-CRISPR-associated-protein-Cas5/CasD	gnl|CDD|187776	cd09645, Cas5_I-E, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex.	1.7638e-37
NC_016786.1|WP_010935667.1|2245681_2246368_+|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	gnl|CDD|187858	cd09727, Cas6_I-E, CRISPR/Cas system-associated RAMP superfamily protein Cas6e. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas6e is an endoribonuclease that generates crRNA; This family is specific for CRISPR/Cas system I-E subtype; Homologous to Cas6 (RAMP superfamily protein); Possesses double RRM/ferredoxin fold; also known as Cse3 family.	2.03816e-50
NC_016786.1|WP_014302522.1|2243759_2245316_-|CRISPR-associated-protein	gnl|CDD|378189	pfam09481, CRISPR_Cse1, CRISPR-associated protein Cse1 (CRISPR_cse1). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This entry, represented by CT1972 from Chlorobaculum tepidum, is found in the CRISPR/Cas subtype Ecoli regions of many bacteria (most of which are mesophiles), and not in Archaea. It is designated Cse1.	0.000117067

Protein sequences

>NC_016786.1|WP_010935670.1|2249959_2250274_+|type-I-E-CRISPR-associated-endoribonuclease-Cas2
MFAVLYLQAAPDHLLGYVTRFLTEADTSIYVGNVSKNVASNLWIRVTEAIKDAHATMIVSDNSREQGFSIMTTGDSTLQVLDADGLSVLASRPGRAAVKLHGLQ
>NC_016786.1|WP_010935669.1|2248999_2249959_+|type-I-E-CRISPR-associated-endonuclease-Cas1
MPYSHDAIAFSTIPASHQIRLEDRLSFLYLEYCLIRQDRTGVIAIQNGHNESSDEEEKLEPQILRIQLPVASLAVLCLGPGTSISNAAMTSCTRSGCTVIFTGGGGVNAYSHATPLTSTAKWAIAQACLVSNTEYQKKAALAFYKRQFGGNAITGGSISVMRGLEGRIMRNTYRENAKKAGIRGFKRDTKAADPVNVGLNISNSILYGAAATVCTAIGVNPALGIIHRGDTRSLLFDLADLYKASIVIPLVFSHAKDEDPVTNIRRHLRREIHSRKIMAGMLEALMEVLTPYLPNRNDDRLIGDSDEVKGHIQYGKEIN
>NC_016786.1|WP_014302523.1|2246367_2248998_+|CRISPR-associated-helicase/endonuclease-Cas3
MNPHEELWAKQKGLAKPYPLLAHLLDSAAVAGALWDHWLRQDLRQMFIEELGSNAREIIQFVVGSHDIGKATPLFQYQKAQKGEVWDSIRYAIDRTGRYQKPLPSSYLVKKTSGGPNRHEQWSSFASKNEYLKPSAAAKENWIGLAIGGHHGRFEPVGYGRHQRKAAEDLAKSGWSAAQQDLLRALEKASGITRASLPSELSPELTLVLSGLTILADRISSTESFVITGARMIDDGTLHLATPIDWLKTRKLDSEKHVAKTVGIYHGWNNHESAIHSILKGYDPRPLQTIALQNQVGLLNLMAPTGNGKTEAAILRHSLKENDRLIFLLPTQATSNAIMRRVQGIYSDTPNAAALAHSLASVEDFYQTPLSVFDDHYDPSKEQFESSMSGGLYPSSFVCSGAARLLAPICIGTVDQALATALPGKWIHLRILALANAHIVIDEVHTLDHYQTALLENILPILAKLKTKITFLTATMPSWQRTKLLTAYGGEDLQIPPTVFPAAETVLPGQFNRTLIDSDSTTIDFTMEETSYDHLVESHVKWHQTTRLNAPHARIGLICNTVKRAQEIAAALEKTNDRIVLLHSRMTTEHRRRSAELLESLLGPNGNRKTITVVGTQAIEASLDIDLDILRTELCPAPSLVQRAGRVWRRNDPYRSSRITADHKPISVVFIAEAKDWQVLPYLRAETSRTQRWLEKHNQMFLPQMAQEFIDAATVDLDTATSEMDLDALALMGIHLMKADGAKARIQDVLNSDSKVSDFALLTSKNEIDEAQTRLIEEGTHLRIILGDENESIPGGWKHGLSSLLKLKASDRESLRTALLASIPLLVSEKQKQLLYQHNLVPLSSSKTVLAGFYFLPKAQNFYSKNLGFIWPEEKD
>NC_016786.1|WP_010935667.1|2245681_2246368_+|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE
MNTKIHLVKLPVHIALSVPAKNKPRKGWELTDPSFRHRAVMALFPDTDSPLPRKSVDILFRFEQLAGQPPFFLIQSTVAPKQVDNLDSEVQHRTVSLRRFSPKSAVRFRISINGIRRQTTEHNGRKRITTSPVPFDSDEKAPSHITRMTPWVQKKLNGALRNVEILNHQREVIGTKHRGGKAASMTIQIDTVDGFGIVEDPELLNELILHGVGRAKAYGCGLLSVSEI
>NC_016786.1|WP_014302522.1|2243759_2245316_-|CRISPR-associated-protein
MSLPGFEISAQFRFLLSVTALLVREEFGRAPSLEQTQSLLQNGFSSAVVEKVNQNLVSHLNVLDGLQPFMGRPRLHPEGPKDASRRIGPGDQEVKKLSPAMPSEQGEDYWNLLVEFPDSLSISEATLKIVTYHYFSMAGNNKFDGDKTRMGAPGIRFPGKGYAATEHIWIREGSSLLRSLLTSLPTSWVKGEGLPAWADRTAQKSRTGQQQFHALWEATWSSNTVVSYWEDGYLTGVRVGGIPPAWWPDIPNTKEGEKALKLWWDQRNEKDPLYFYLKNKKGEPKAQRIDFGRDGIDLAVEWAAEAKMMDLVEKTYKNVLPVDSYPTVDGDDEGIDKYQLVFFRHQVEGTASSPSIRASEVFLADRSVWAFDLSCDEQLRLRDNAQLVRDVYITLLGVFRRKSAADASREVATGWGAAVLDSLAVSQSDASDAYWRGVTDVYQKYLADLRVGEEITEELYRGIRSAALEAYDEVTAPYLAQYANEIYYVRASLVRSVNSKINTARDEGIGRIKEESNE
>NC_016786.1|WP_014302521.1|2243182_2243767_-|type-I-E-CRISPR-associated-protein-Cse2/CasB
MSEKLVLNSGKCFLHEVLCRREEKEYRQTRANLRRGADTTTEVYAFPYVYPQLPQEATTQERLVLMRVAALAAEFGNIPAVGSDTPAKSLGRWAYEVSRQRMLDRQQQVAFNPKKLDVVGERLAYLHTQDFEEAVRAVSRLMSIASSLSNVPAFDYIALYSLFSYWGNGISEKSQRVRMRVLQDYYGSFGSLIE
>NC_016786.1|WP_010935664.1|2242068_2243127_-|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC
MSRHLTFHIITNVPYSNLNRDDSGTPKRVSLGGALRALHSSQSIKRGIRTKYELASLDTSIRSGKLVEEVVRVGLDLKPEVDEKLLRKGAAKIIGSLTKGESSEGESARSAWMSREEITTAAQTVIDGQEDSDFIQDNRTGSLAIAAFGRMFANAPKKNTEAALAVSPGVTTHAVTIETDYFSTVDDVREREHDSGATFLGVARYVNGTFYRTVSIDKEQLRESWSGFGQEESVDNLRELIKAIVYGAPRGKENSTAPYTLPSLVFAEEQHYRTAYSFETPVLVGKDGGFEFPTICELDRQFARARSFDKGNFGPLEVVSGTAVLEDEQFEGVQRSDLNGLIEAVVNWVTND
>NC_016786.1|WP_010935663.1|2241347_2242076_-|type-I-E-CRISPR-associated-protein-Cas5/CasD
MIESAYIRLSGPLQSWAGSVVTGNIVRTEPRPTFSSLRGLLAGALGARRGEWPNWLDDVEFWVREDRKPIVVNEFQTINPLPEVETFRKRLLIAQGRKANSAKALTFTPDAQGGTSIVNRTYLADGEYLVRVTSSTHMDEIENAFSSPAFVTYLGRKAFYAEFPFYLGRGSADAFEKIPVVHRNSDESKAQKSQVVLATKFGRYFPVSGLHSKIQIPVVESDDARLTQISDLLDIRRTAANR
>NC_016786.1|WP_014302520.1|2239418_2241239_+|N-acetylmuramoyl-L-alanine-amidase
MQQRRRLISRTPKPVTAAIMAITLVGAAAVGVSTNSVLFTQGDAIAPINPELTTSSLADGNNVLVTDPAIATQGEGEGPKTVKEFHREQPFSQFALTWNGERDIAAFVRGQRPDGTWTEWFDTEPLDYGSDNPNHKKGTDLIYIEPTTTVQVSISGVDVLGPDAANLDAVFIDGGTSDLPENGINLTADSDGMPRVISRAGWGADESLRCSRPEYEDSTAAIVIHHTAGSNNYSQKESPGIMRGIYKYHAQTLGWCDIGYHALADKYGNLFEGRYGGLNKSIVGAHAGGFNSNTWAISMMGNYDVVQPPQAMIKSVGELAGWRAKVAGIDPKGSDTHYSEGSSYTFYPYGQAVLLPNIFAHRDVGNTACPGRYGYAQMDNIRNIAKQKYDSIRSGSGATAPAAPSTPSKPAPAPAAPAAPSAPAAPAGTNPIGLLSQGSTPANAGSLVGLAVAAATSLGLIGNLNNIGDVPVIGGLKLSQLQPIIGKIVELLGNNDVSRVWRDVNSFAGAALGNARSPIAHYASATGTPIDYALFDNGIVISNPETGTNALWGTIGDLWAQQGFEAGPLGLPTSSVFEVDGLQRVNFQHGYITFNPTTSAVDIQVQ
>NC_016786.1|WP_010935661.1|2238673_2238949_-|ATP-binding-cassette-domain-containing-protein
MTDTLDLSPKREVARLFGGQAQRVVLARAFVQQPDVLLLDEPTSVLDIGHAQDVLELIDAMRTTRNLTVERVEKIYNAKVKTCGRIIVPRR
>NC_016786.1|WP_158308708.1|2250587_2250761_+|hypothetical-protein
MMRVSDGSLMDSESQKILSDIATETGFQVWVELVDETGEHGIVIEDGQVRELIEEAV
>NC_016786.1|WP_010935671.1|2250819_2251335_+|single-stranded-DNA-binding-protein
MAQGEVNVTIVGNLVADPELRFTPNGVAVTSFRVASTSKKYDSRSNQWVDGDAVFLQCNIWHQAAENVAESLTKGMRVIVTGRLRQRSYETREGEKCTVMELEADEVGPSLRYASASVMRNERNSGGNGVGSQPSTGGFGGQVSQPQSGGQSQGSDGWNNPAPLGDDNPPW
>NC_016786.1|WP_014302525.1|2251353_2251551_+|hypothetical-protein
MRKDDLKEAALVAMREYYVARDVLAEKRSIAKKALKTAKLCGVTNRELAEELPTSESALSRFSAG
>NC_016786.1|WP_014302526.1|2252053_2252731_+|hypothetical-protein
MDGLRLLARQDFAQWWKTTGDLNRLRDHFYEIQRLYGEQAAAAAVDYLVLNRSLDDDFAGLPFPETADPVKYEQASASFSWVMQTVASHQSEIDRVAAKQRLFGVLDRLVTLPARDTVVLNVQRDHTAYARVPEPGACAFCLMLASRGAVYKKSTVGMVNKYHDHCRCLGIEVKRDGSDLPRINRDLERVWSNLSHDLGLPLTLRILIGIYANSKRLSSGLRFNG
>NC_016786.1|WP_014302527.1|2252757_2253147_+|hypothetical-protein
MPKAFPGEPLPKELNRLVGHVLYGWRDRPRRGEVDYPHTENIRMGHTWDSKRDVSKFDKSWSDQNIVDAIVATLENPDYALSGKVKRVVWKDIHGTTVRVSYNVCLMVGVISDRAYSDTPDRKAKRIVE
>NC_016786.1|WP_010935675.1|2253136_2253412_+|hypothetical-protein
MLSSKEVYARLDAILPSSVDREDAESNLNAGEIEYAITALLDDAYTSVGLSDAVVSLIRENYDDGPVIDMLDALLYFQKLNSGGDAVRMQR
>NC_016786.1|WP_014302528.1|2253567_2253717_+|hypothetical-protein
MTSRIIGSLAALTVAIGCTIVAPAIWPITTALATISIINIRTQLRKEKE
>NC_016786.1|WP_014308874.1|2253874_2254684_-|SpaH-fimbrial-minor-subunit-SpaI
MKKSHLFRIPAATTAAVALLLASGPIANADGRTITGATDGLNISDIRCDTGSLTLIKRPPAAFEGVDKADLPAGTIDGATFTLRRIEGIDLTKQAGWDAAKALTIQEARSRLSDEVWKAVSGRDGRAVVTGLPMGVYLVSETPPAKRPAEYRRTLDFLITVPAGMRTADGNVASWSCDVQVFTKDTDDLPPTVPVFPPVESSVTLTPSSPVPGTPKTPGKPDLPEKFRKEVTDRLGNTGANVLGIAALGIALAIAGFLVQRRKKNEENG
>NC_016786.1|WP_014309675.1|2254757_2255804_-|SpaH-fimbrial-biogenesis-class-C-sortase-SrtE
MAMNSETAGKEPNVVSTDAKHSTGTSSNAGTGESSAKKKAQTTIAAIVMLLCGLLGLVILFYPVVSTQLNNYEQSKLARQFGADAAQADPAVVAAALDAAHAYNDSLENGPLQDPWTGGDSTKDPAYQAYEKLLGEYPAMAQISIPAISVNLPVYHGTSDATLLKGVGHLYGTALPVGGLGTRSVLTAHSGIQKSTFFDNLEKVKKGDAIYVRNIGETLKYQVRDTEIIRPAEIDRIQPIPDRDLITLVTCTPYGINTHRLLVTAERVPMEPGEADRAFAGDGIVWQWWMKLAIGVLVVILLLTGWLIIRILRARKFAKKTAGADAAKSVEPSDTEASLSTSAAEESQ
>NC_016786.1|WP_014302532.1|2255787_2256744_-|SpaH-fimbrial-biogenesis-class-C-sortase-SrtD
MVTTASPRSTGPDNPDAQPKRRWVFSGLALFACITALAGLMLGLYPSTAAWFNAREQAKLVDLYDSKIENATPLSAEQLLELAHRYNDRLTVGAALDPWANVPRGAGKEDGDGMAYKDQLRVDRTDVMARIRIPSIKVDLPIYHGTSDDTLKKGAGHLEGTSLPVGGPRTHSVITAHRGLAEATMFTNLNKVGVGDRFTIEVMGEVLTYEVRETRVVSPEDTRFLQTQDDRDLVTLVTCTPLGINTHRILVTAERITSTPQSDIDAARQASQIGFPWWAVIFAVGFSFIALFFWRSGYMIPPKKKEEDIEGEADGDEL

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_016786_1	1.15|40528|28|NC_016786|CRISPRCasFinder,CRT,PILER-CR	40528-40555	28	KY613597	Corynebacterium phage LGCM-V2, complete genome	23261-23288	2	0.929
NC_016786_1	1.15|40528|28|NC_016786|CRISPRCasFinder,CRT,PILER-CR	40528-40555	28	KY624612	Corynebacterium phage LGCM-V6, complete genome	23261-23288	2	0.929
NC_016786_1	1.15|40528|28|NC_016786|CRISPRCasFinder,CRT,PILER-CR	40528-40555	28	KY566218	Corynebacterium phage LGCM-VI, complete genome	23261-23288	2	0.929
NC_016786_1	1.15|40528|28|NC_016786|CRISPRCasFinder,CRT,PILER-CR	40528-40555	28	KY624613	Corynebacterium phage LGCM-V5, complete genome	23261-23288	2	0.929
NC_016786_1	1.15|40528|28|NC_016786|CRISPRCasFinder,CRT,PILER-CR	40528-40555	28	KY624615	Corynebacterium phage LGCM-V8, complete genome	23261-23288	2	0.929
NC_016786_1	1.15|40528|28|NC_016786|CRISPRCasFinder,CRT,PILER-CR	40528-40555	28	KY624611	Corynebacterium phage LGCM-V4, complete genome	23264-23291	2	0.929
NC_016786_1	1.15|40528|28|NC_016786|CRISPRCasFinder,CRT,PILER-CR	40528-40555	28	KY624616	Corynebacterium phage LGCM-V9, complete genome	23261-23288	2	0.929
NC_016786_1	1.15|40528|28|NC_016786|CRISPRCasFinder,CRT,PILER-CR	40528-40555	28	KY624610	Corynebacterium phage LGCM-V3, complete genome	23261-23288	2	0.929
NC_016786_1	1.15|40528|28|NC_016786|CRISPRCasFinder,CRT,PILER-CR	40528-40555	28	KY624614	Corynebacterium phage LGCM-V7, complete genome	23261-23288	2	0.929
NC_016786_1	1.16|40592|27|NC_016786|CRT	40592-40618	27	NC_017130	Acetobacter pasteurianus IFO 3283-26 plasmid pAPA26-013, complete sequence	124188-124214	4	0.852
NC_016786_1	1.16|40592|27|NC_016786|CRT	40592-40618	27	NC_017130	Acetobacter pasteurianus IFO 3283-26 plasmid pAPA26-013, complete sequence	124066-124092	4	0.852
NC_016786_1	1.16|40592|27|NC_016786|CRT	40592-40618	27	NC_017134	Acetobacter pasteurianus IFO 3283-32 plasmid pAPA32-012, complete sequence	124212-124238	4	0.852
NC_016786_1	1.16|40592|27|NC_016786|CRT	40592-40618	27	NC_017134	Acetobacter pasteurianus IFO 3283-32 plasmid pAPA32-012, complete sequence	124090-124116	4	0.852
NC_016786_1	1.16|40592|27|NC_016786|CRT	40592-40618	27	NC_017101	Acetobacter pasteurianus IFO 3283-03 plasmid pAPA03-010, complete sequence	124196-124222	4	0.852
NC_016786_1	1.16|40592|27|NC_016786|CRT	40592-40618	27	NC_017101	Acetobacter pasteurianus IFO 3283-03 plasmid pAPA03-010, complete sequence	124074-124100	4	0.852
NC_016786_1	1.16|40592|27|NC_016786|CRT	40592-40618	27	NZ_CP021924	Acetobacter pasteurianus subsp. pasteurianus strain SRCM101468 plasmid pAP1468-2	170385-170411	4	0.852
NC_016786_1	1.16|40592|27|NC_016786|CRT	40592-40618	27	NZ_CP021924	Acetobacter pasteurianus subsp. pasteurianus strain SRCM101468 plasmid pAP1468-2	171117-171143	4	0.852
NC_016786_1	1.16|40592|27|NC_016786|CRT	40592-40618	27	NC_013210	Acetobacter pasteurianus IFO 3283-01 plasmid pAPA01-011, complete sequence	124568-124594	4	0.852
NC_016786_1	1.16|40592|27|NC_016786|CRT	40592-40618	27	NC_013210	Acetobacter pasteurianus IFO 3283-01 plasmid pAPA01-011, complete sequence	124446-124472	4	0.852
NC_016786_1	1.16|40592|27|NC_016786|CRT	40592-40618	27	NC_017136	Acetobacter pasteurianus IFO 3283-12 plasmid pAPA12-014, complete sequence	124180-124206	4	0.852
NC_016786_1	1.16|40592|27|NC_016786|CRT	40592-40618	27	NC_017136	Acetobacter pasteurianus IFO 3283-12 plasmid pAPA12-014, complete sequence	124058-124084	4	0.852
NC_016786_1	1.4|39824|28|NC_016786|CRISPRCasFinder,CRT	39824-39851	28	HM486077	Tsukamurella phage TPA2, complete sequence	35453-35480	5	0.821
NC_016786_1	1.4|39824|28|NC_016786|CRISPRCasFinder,CRT	39824-39851	28	NC_015210	Tsukamurella phage TPA2, complete genome	35453-35480	5	0.821
NC_016786_1	1.16|40592|27|NC_016786|CRT	40592-40618	27	NC_017130	Acetobacter pasteurianus IFO 3283-26 plasmid pAPA26-013, complete sequence	123517-123543	5	0.815
NC_016786_1	1.16|40592|27|NC_016786|CRT	40592-40618	27	NC_017134	Acetobacter pasteurianus IFO 3283-32 plasmid pAPA32-012, complete sequence	123541-123567	5	0.815
NC_016786_1	1.16|40592|27|NC_016786|CRT	40592-40618	27	NZ_CP009803	Streptomyces sp. FR-008 plasmid pSSFR1, complete sequence	80081-80107	5	0.815
NC_016786_1	1.16|40592|27|NC_016786|CRT	40592-40618	27	NC_017101	Acetobacter pasteurianus IFO 3283-03 plasmid pAPA03-010, complete sequence	123525-123551	5	0.815
NC_016786_1	1.16|40592|27|NC_016786|CRT	40592-40618	27	NZ_CP020471	Rhodobacter blasticus strain 28/5 plasmid pRsa, complete sequence	88022-88048	5	0.815
NC_016786_1	1.16|40592|27|NC_016786|CRT	40592-40618	27	LC542972	Escherichia coli IOMTU792 plasmid pIOMTU792 DNA, complete sequence	246793-246819	5	0.815
NC_016786_1	1.16|40592|27|NC_016786|CRT	40592-40618	27	NZ_CP021924	Acetobacter pasteurianus subsp. pasteurianus strain SRCM101468 plasmid pAP1468-2	170263-170289	5	0.815
NC_016786_1	1.16|40592|27|NC_016786|CRT	40592-40618	27	NC_013210	Acetobacter pasteurianus IFO 3283-01 plasmid pAPA01-011, complete sequence	123897-123923	5	0.815
NC_016786_1	1.16|40592|27|NC_016786|CRT	40592-40618	27	NC_017136	Acetobacter pasteurianus IFO 3283-12 plasmid pAPA12-014, complete sequence	123509-123535	5	0.815
NC_016786_1	1.16|40592|27|NC_016786|CRT	40592-40618	27	MK977714	Corynebacterium phage Bran, complete genome	22540-22566	5	0.815
NC_016786_1	1.16|40592|27|NC_016786|CRT	40592-40618	27	NC_048780	Corynebacterium phage StAB, complete genome	22546-22572	5	0.815
NC_016786_1	1.16|40592|27|NC_016786|CRT	40592-40618	27	MK977706	Corynebacterium phage Dina, complete genome	22371-22397	5	0.815
NC_016786_1	1.16|40592|27|NC_016786|CRT	40592-40618	27	MH926061	Corynebacterium phage Troy, complete genome	22111-22137	5	0.815
NC_016786_1	1.16|40592|27|NC_016786|CRT	40592-40618	27	NC_048789	Corynebacterium phage Stiles, complete genome	22038-22064	5	0.815
NC_016786_1	1.16|40592|27|NC_016786|CRT	40592-40618	27	NC_048069	Corynebacterium phage SamW, complete genome	22111-22137	5	0.815
NC_016786_1	1.16|40592|27|NC_016786|CRT	40592-40618	27	NC_048790	Corynebacterium phage Lederberg, complete genome	22496-22522	5	0.815
NC_016786_1	1.1|39632|28|NC_016786|CRISPRCasFinder,CRT	39632-39659	28	NZ_CP029232	Sinorhizobium fredii CCBAU 45436 plasmid pSF45436b, complete sequence	67353-67380	6	0.786
NC_016786_1	1.6|39952|28|NC_016786|CRISPRCasFinder,CRT	39952-39979	28	NZ_CP017759	Cupriavidus necator strain NH9 plasmid pENH92, complete sequence	303185-303212	6	0.786
NC_016786_1	1.15|40528|28|NC_016786|CRISPRCasFinder,CRT,PILER-CR	40528-40555	28	CP008937	Candidatus Caedibacter acanthamoebae plasmid Plasmid_00001, complete sequence	142823-142850	6	0.786
NC_016786_1	1.16|40592|27|NC_016786|CRT	40592-40618	27	NC_017130	Acetobacter pasteurianus IFO 3283-26 plasmid pAPA26-013, complete sequence	123395-123421	6	0.778
NC_016786_1	1.16|40592|27|NC_016786|CRT	40592-40618	27	NC_017134	Acetobacter pasteurianus IFO 3283-32 plasmid pAPA32-012, complete sequence	123419-123445	6	0.778
NC_016786_1	1.16|40592|27|NC_016786|CRT	40592-40618	27	NC_017101	Acetobacter pasteurianus IFO 3283-03 plasmid pAPA03-010, complete sequence	123403-123429	6	0.778
NC_016786_1	1.16|40592|27|NC_016786|CRT	40592-40618	27	LC542972	Escherichia coli IOMTU792 plasmid pIOMTU792 DNA, complete sequence	246732-246758	6	0.778
NC_016786_1	1.16|40592|27|NC_016786|CRT	40592-40618	27	NC_013210	Acetobacter pasteurianus IFO 3283-01 plasmid pAPA01-011, complete sequence	123775-123801	6	0.778
NC_016786_1	1.16|40592|27|NC_016786|CRT	40592-40618	27	NC_017136	Acetobacter pasteurianus IFO 3283-12 plasmid pAPA12-014, complete sequence	123387-123413	6	0.778
NC_016786_1	1.1|39632|28|NC_016786|CRISPRCasFinder,CRT	39632-39659	28	NZ_CP017244	Rhizobium etli 8C-3 plasmid pRsp8C3c, complete sequence	653342-653369	7	0.75
NC_016786_1	1.1|39632|28|NC_016786|CRISPRCasFinder,CRT	39632-39659	28	MN871474	UNVERIFIED: Pseudomonas virus Pa-oumiga, complete genome	15587-15614	7	0.75
NC_016786_1	1.1|39632|28|NC_016786|CRISPRCasFinder,CRT	39632-39659	28	MN871471	UNVERIFIED: Pseudomonas virus Pa-V, complete genome	15586-15613	7	0.75
NC_016786_1	1.1|39632|28|NC_016786|CRISPRCasFinder,CRT	39632-39659	28	MN871472	UNVERIFIED: Pseudomonas virus Pa-X, complete genome	14494-14521	7	0.75
NC_016786_1	1.1|39632|28|NC_016786|CRISPRCasFinder,CRT	39632-39659	28	NC_006569	Ruegeria pomeroyi DSS-3 megaplasmid, complete sequence	255789-255816	7	0.75
NC_016786_1	1.1|39632|28|NC_016786|CRISPRCasFinder,CRT	39632-39659	28	MK816297	Pseudomonas virus PBPA162, complete genome	27599-27626	7	0.75
NC_016786_1	1.4|39824|28|NC_016786|CRISPRCasFinder,CRT	39824-39851	28	NC_012855	Ralstonia pickettii 12D plasmid pRp12D01, complete sequence	61916-61943	7	0.75
NC_016786_1	1.7|40016|28|NC_016786|CRISPRCasFinder,CRT	40016-40043	28	MN693198	Marine virus AFVG_25M132, complete genome	15426-15453	7	0.75
NC_016786_1	1.10|40208|28|NC_016786|CRISPRCasFinder,CRT,PILER-CR	40208-40235	28	MF459646	Erwinia phage vB_EamM_RisingSun, complete genome	139358-139385	7	0.75
NC_016786_1	1.11|40272|28|NC_016786|CRISPRCasFinder,CRT,PILER-CR	40272-40299	28	NC_048170	Escherichia phage vB_EcoM_Goslar, complete genome	202462-202489	7	0.75

1. spacer 1.15|40528|28|NC_016786|CRISPRCasFinder,CRT,PILER-CR matches to KY613597 (Corynebacterium phage LGCM-V2, complete genome) position: , mismatch: 2, identity: 0.929

catgctgactcctgccatcctcaatctg	CRISPR spacer
catgctgactcctgccattatcaatctg	Protospacer
******************. ********

2. spacer 1.15|40528|28|NC_016786|CRISPRCasFinder,CRT,PILER-CR matches to KY624612 (Corynebacterium phage LGCM-V6, complete genome) position: , mismatch: 2, identity: 0.929

catgctgactcctgccatcctcaatctg	CRISPR spacer
catgctgactcctgccattatcaatctg	Protospacer
******************. ********

3. spacer 1.15|40528|28|NC_016786|CRISPRCasFinder,CRT,PILER-CR matches to KY566218 (Corynebacterium phage LGCM-VI, complete genome) position: , mismatch: 2, identity: 0.929

catgctgactcctgccatcctcaatctg	CRISPR spacer
catgctgactcctgccattatcaatctg	Protospacer
******************. ********

4. spacer 1.15|40528|28|NC_016786|CRISPRCasFinder,CRT,PILER-CR matches to KY624613 (Corynebacterium phage LGCM-V5, complete genome) position: , mismatch: 2, identity: 0.929

catgctgactcctgccatcctcaatctg	CRISPR spacer
catgctgactcctgccattatcaatctg	Protospacer
******************. ********

5. spacer 1.15|40528|28|NC_016786|CRISPRCasFinder,CRT,PILER-CR matches to KY624615 (Corynebacterium phage LGCM-V8, complete genome) position: , mismatch: 2, identity: 0.929

catgctgactcctgccatcctcaatctg	CRISPR spacer
catgctgactcctgccattatcaatctg	Protospacer
******************. ********

6. spacer 1.15|40528|28|NC_016786|CRISPRCasFinder,CRT,PILER-CR matches to KY624611 (Corynebacterium phage LGCM-V4, complete genome) position: , mismatch: 2, identity: 0.929

catgctgactcctgccatcctcaatctg	CRISPR spacer
catgctgactcctgccattatcaatctg	Protospacer
******************. ********

7. spacer 1.15|40528|28|NC_016786|CRISPRCasFinder,CRT,PILER-CR matches to KY624616 (Corynebacterium phage LGCM-V9, complete genome) position: , mismatch: 2, identity: 0.929

catgctgactcctgccatcctcaatctg	CRISPR spacer
catgctgactcctgccattatcaatctg	Protospacer
******************. ********

8. spacer 1.15|40528|28|NC_016786|CRISPRCasFinder,CRT,PILER-CR matches to KY624610 (Corynebacterium phage LGCM-V3, complete genome) position: , mismatch: 2, identity: 0.929

catgctgactcctgccatcctcaatctg	CRISPR spacer
catgctgactcctgccattatcaatctg	Protospacer
******************. ********

9. spacer 1.15|40528|28|NC_016786|CRISPRCasFinder,CRT,PILER-CR matches to KY624614 (Corynebacterium phage LGCM-V7, complete genome) position: , mismatch: 2, identity: 0.929

catgctgactcctgccatcctcaatctg	CRISPR spacer
catgctgactcctgccattatcaatctg	Protospacer
******************. ********

10. spacer 1.16|40592|27|NC_016786|CRT matches to NC_017130 (Acetobacter pasteurianus IFO 3283-26 plasmid pAPA26-013, complete sequence) position: , mismatch: 4, identity: 0.852

ccgcaccagcggggatgaaccgtagga	CRISPR spacer
ccgcacacgcggggatgaaccgtaaca	Protospacer
******  ****************. *

11. spacer 1.16|40592|27|NC_016786|CRT matches to NC_017130 (Acetobacter pasteurianus IFO 3283-26 plasmid pAPA26-013, complete sequence) position: , mismatch: 4, identity: 0.852

ccgcaccagcggggatgaaccgtagga	CRISPR spacer
ccgcacacgcggggatgaaccgtcgca	Protospacer
******  *************** * *

12. spacer 1.16|40592|27|NC_016786|CRT matches to NC_017134 (Acetobacter pasteurianus IFO 3283-32 plasmid pAPA32-012, complete sequence) position: , mismatch: 4, identity: 0.852

ccgcaccagcggggatgaaccgtagga	CRISPR spacer
ccgcacacgcggggatgaaccgtaaca	Protospacer
******  ****************. *

13. spacer 1.16|40592|27|NC_016786|CRT matches to NC_017134 (Acetobacter pasteurianus IFO 3283-32 plasmid pAPA32-012, complete sequence) position: , mismatch: 4, identity: 0.852

ccgcaccagcggggatgaaccgtagga	CRISPR spacer
ccgcacacgcggggatgaaccgtcgca	Protospacer
******  *************** * *

14. spacer 1.16|40592|27|NC_016786|CRT matches to NC_017101 (Acetobacter pasteurianus IFO 3283-03 plasmid pAPA03-010, complete sequence) position: , mismatch: 4, identity: 0.852

ccgcaccagcggggatgaaccgtagga	CRISPR spacer
ccgcacacgcggggatgaaccgtaaca	Protospacer
******  ****************. *

15. spacer 1.16|40592|27|NC_016786|CRT matches to NC_017101 (Acetobacter pasteurianus IFO 3283-03 plasmid pAPA03-010, complete sequence) position: , mismatch: 4, identity: 0.852

ccgcaccagcggggatgaaccgtagga	CRISPR spacer
ccgcacacgcggggatgaaccgtcgca	Protospacer
******  *************** * *

16. spacer 1.16|40592|27|NC_016786|CRT matches to NZ_CP021924 (Acetobacter pasteurianus subsp. pasteurianus strain SRCM101468 plasmid pAP1468-2) position: , mismatch: 4, identity: 0.852

ccgcaccagcggggatgaaccgtagga	CRISPR spacer
ccgcacacgcggggatgaaccgtaaca	Protospacer
******  ****************. *

17. spacer 1.16|40592|27|NC_016786|CRT matches to NZ_CP021924 (Acetobacter pasteurianus subsp. pasteurianus strain SRCM101468 plasmid pAP1468-2) position: , mismatch: 4, identity: 0.852

ccgcaccagcggggatgaaccgtagga	CRISPR spacer
ccgcacacgcggggatgaaccgtaaca	Protospacer
******  ****************. *

18. spacer 1.16|40592|27|NC_016786|CRT matches to NC_013210 (Acetobacter pasteurianus IFO 3283-01 plasmid pAPA01-011, complete sequence) position: , mismatch: 4, identity: 0.852

ccgcaccagcggggatgaaccgtagga	CRISPR spacer
ccgcacacgcggggatgaaccgtaaca	Protospacer
******  ****************. *

19. spacer 1.16|40592|27|NC_016786|CRT matches to NC_013210 (Acetobacter pasteurianus IFO 3283-01 plasmid pAPA01-011, complete sequence) position: , mismatch: 4, identity: 0.852

ccgcaccagcggggatgaaccgtagga	CRISPR spacer
ccgcacacgcggggatgaaccgtcgca	Protospacer
******  *************** * *

20. spacer 1.16|40592|27|NC_016786|CRT matches to NC_017136 (Acetobacter pasteurianus IFO 3283-12 plasmid pAPA12-014, complete sequence) position: , mismatch: 4, identity: 0.852

ccgcaccagcggggatgaaccgtagga	CRISPR spacer
ccgcacacgcggggatgaaccgtaaca	Protospacer
******  ****************. *

21. spacer 1.16|40592|27|NC_016786|CRT matches to NC_017136 (Acetobacter pasteurianus IFO 3283-12 plasmid pAPA12-014, complete sequence) position: , mismatch: 4, identity: 0.852

ccgcaccagcggggatgaaccgtagga	CRISPR spacer
ccgcacacgcggggatgaaccgtcgca	Protospacer
******  *************** * *

22. spacer 1.4|39824|28|NC_016786|CRISPRCasFinder,CRT matches to HM486077 (Tsukamurella phage TPA2, complete sequence) position: , mismatch: 5, identity: 0.821

gcttcgt-ggcgcgaccaccgcggatcac	CRISPR spacer
-caacgcgggcgcgatcaccgcggatcac	Protospacer
 *  **. *******.*************

23. spacer 1.4|39824|28|NC_016786|CRISPRCasFinder,CRT matches to NC_015210 (Tsukamurella phage TPA2, complete genome) position: , mismatch: 5, identity: 0.821

gcttcgt-ggcgcgaccaccgcggatcac	CRISPR spacer
-caacgcgggcgcgatcaccgcggatcac	Protospacer
 *  **. *******.*************

24. spacer 1.16|40592|27|NC_016786|CRT matches to NC_017130 (Acetobacter pasteurianus IFO 3283-26 plasmid pAPA26-013, complete sequence) position: , mismatch: 5, identity: 0.815

ccgcaccagcggggatgaaccgtagga	CRISPR spacer
ccgcacacgcggggatgaaccgtcgcc	Protospacer
******  *************** *  

25. spacer 1.16|40592|27|NC_016786|CRT matches to NC_017134 (Acetobacter pasteurianus IFO 3283-32 plasmid pAPA32-012, complete sequence) position: , mismatch: 5, identity: 0.815

ccgcaccagcggggatgaaccgtagga	CRISPR spacer
ccgcacacgcggggatgaaccgtcgcc	Protospacer
******  *************** *  

26. spacer 1.16|40592|27|NC_016786|CRT matches to NZ_CP009803 (Streptomyces sp. FR-008 plasmid pSSFR1, complete sequence) position: , mismatch: 5, identity: 0.815

ccgcaccagcggggatgaaccgtagga	CRISPR spacer
ccgcaccagcggggatgctccgtacct	Protospacer
*****************  *****   

27. spacer 1.16|40592|27|NC_016786|CRT matches to NC_017101 (Acetobacter pasteurianus IFO 3283-03 plasmid pAPA03-010, complete sequence) position: , mismatch: 5, identity: 0.815

ccgcaccagcggggatgaaccgtagga	CRISPR spacer
ccgcacacgcggggatgaaccgtcgcc	Protospacer
******  *************** *  

28. spacer 1.16|40592|27|NC_016786|CRT matches to NZ_CP020471 (Rhodobacter blasticus strain 28/5 plasmid pRsa, complete sequence) position: , mismatch: 5, identity: 0.815

ccgcaccagcggggatgaaccgtagga	CRISPR spacer
ccgcacacgcggggatgaaccgtatcc	Protospacer
******  ****************   

29. spacer 1.16|40592|27|NC_016786|CRT matches to LC542972 (Escherichia coli IOMTU792 plasmid pIOMTU792 DNA, complete sequence) position: , mismatch: 5, identity: 0.815

ccgcaccagcggggatgaaccgtagga	CRISPR spacer
ccgcgccagcggggataaaccgttgtc	Protospacer
****.***********.****** *  

30. spacer 1.16|40592|27|NC_016786|CRT matches to NZ_CP021924 (Acetobacter pasteurianus subsp. pasteurianus strain SRCM101468 plasmid pAP1468-2) position: , mismatch: 5, identity: 0.815

ccgcaccagcggggatgaaccgtagga	CRISPR spacer
ccgcacacgcggggatgaaccgttaaa	Protospacer
******  *************** ..*

31. spacer 1.16|40592|27|NC_016786|CRT matches to NC_013210 (Acetobacter pasteurianus IFO 3283-01 plasmid pAPA01-011, complete sequence) position: , mismatch: 5, identity: 0.815

ccgcaccagcggggatgaaccgtagga	CRISPR spacer
ccgcacacgcggggatgaaccgtcgcc	Protospacer
******  *************** *  

32. spacer 1.16|40592|27|NC_016786|CRT matches to NC_017136 (Acetobacter pasteurianus IFO 3283-12 plasmid pAPA12-014, complete sequence) position: , mismatch: 5, identity: 0.815

ccgcaccagcggggatgaaccgtagga	CRISPR spacer
ccgcacacgcggggatgaaccgtcgcc	Protospacer
******  *************** *  

33. spacer 1.16|40592|27|NC_016786|CRT matches to MK977714 (Corynebacterium phage Bran, complete genome) position: , mismatch: 5, identity: 0.815

ccgcaccagcggggatgaaccgtagga	CRISPR spacer
ccgcgccagcggggatgagccgtttgc	Protospacer
****.*************.****  * 

34. spacer 1.16|40592|27|NC_016786|CRT matches to NC_048780 (Corynebacterium phage StAB, complete genome) position: , mismatch: 5, identity: 0.815

ccgcaccagcggggatgaaccgtagga	CRISPR spacer
ccgcgccagcggggatgagccgtttgc	Protospacer
****.*************.****  * 

35. spacer 1.16|40592|27|NC_016786|CRT matches to MK977706 (Corynebacterium phage Dina, complete genome) position: , mismatch: 5, identity: 0.815

ccgcaccagcggggatgaaccgtagga	CRISPR spacer
ccgcgccagcggggatgagccgtttgc	Protospacer
****.*************.****  * 

36. spacer 1.16|40592|27|NC_016786|CRT matches to MH926061 (Corynebacterium phage Troy, complete genome) position: , mismatch: 5, identity: 0.815

ccgcaccagcggggatgaaccgtagga	CRISPR spacer
ccgcgccagcggggatgagccgtttgc	Protospacer
****.*************.****  * 

37. spacer 1.16|40592|27|NC_016786|CRT matches to NC_048789 (Corynebacterium phage Stiles, complete genome) position: , mismatch: 5, identity: 0.815

ccgcaccagcggggatgaaccgtagga	CRISPR spacer
ccgcgccagcggggatgagccgtttgt	Protospacer
****.*************.****  * 

38. spacer 1.16|40592|27|NC_016786|CRT matches to NC_048069 (Corynebacterium phage SamW, complete genome) position: , mismatch: 5, identity: 0.815

ccgcaccagcggggatgaaccgtagga	CRISPR spacer
ccgcgccagcggggatgagccgtttgc	Protospacer
****.*************.****  * 

39. spacer 1.16|40592|27|NC_016786|CRT matches to NC_048790 (Corynebacterium phage Lederberg, complete genome) position: , mismatch: 5, identity: 0.815

ccgcaccagcggggatgaaccgtagga	CRISPR spacer
ccgcgccagcggggatgagccgtttgc	Protospacer
****.*************.****  * 

40. spacer 1.1|39632|28|NC_016786|CRISPRCasFinder,CRT matches to NZ_CP029232 (Sinorhizobium fredii CCBAU 45436 plasmid pSF45436b, complete sequence) position: , mismatch: 6, identity: 0.786

gcgtcgatgatgtctttttcgatggtgg	CRISPR spacer
accctgatgatgtcgctttcgatggtgg	Protospacer
.* ..********* .************

41. spacer 1.6|39952|28|NC_016786|CRISPRCasFinder,CRT matches to NZ_CP017759 (Cupriavidus necator strain NH9 plasmid pENH92, complete sequence) position: , mismatch: 6, identity: 0.786

ttacagcaggcatgtacgtggaagagga	CRISPR spacer
atcgggtaggcatctacgtggaagagga	Protospacer
 *  .*.****** **************

42. spacer 1.15|40528|28|NC_016786|CRISPRCasFinder,CRT,PILER-CR matches to CP008937 (Candidatus Caedibacter acanthamoebae plasmid Plasmid_00001, complete sequence) position: , mismatch: 6, identity: 0.786

catgctgactcctgccatcctcaatctg	CRISPR spacer
tttgcttactcctgccaacctcaatatt	Protospacer
. **** ********** ******* * 

43. spacer 1.16|40592|27|NC_016786|CRT matches to NC_017130 (Acetobacter pasteurianus IFO 3283-26 plasmid pAPA26-013, complete sequence) position: , mismatch: 6, identity: 0.778

ccgcaccagcggggatgaaccgtagga	CRISPR spacer
ccgcacacgcggggatgaaccgttcag	Protospacer
******  ***************  ..

44. spacer 1.16|40592|27|NC_016786|CRT matches to NC_017134 (Acetobacter pasteurianus IFO 3283-32 plasmid pAPA32-012, complete sequence) position: , mismatch: 6, identity: 0.778

ccgcaccagcggggatgaaccgtagga	CRISPR spacer
ccgcacacgcggggatgaaccgttcag	Protospacer
******  ***************  ..

45. spacer 1.16|40592|27|NC_016786|CRT matches to NC_017101 (Acetobacter pasteurianus IFO 3283-03 plasmid pAPA03-010, complete sequence) position: , mismatch: 6, identity: 0.778

ccgcaccagcggggatgaaccgtagga	CRISPR spacer
ccgcacacgcggggatgaaccgttcag	Protospacer
******  ***************  ..

46. spacer 1.16|40592|27|NC_016786|CRT matches to LC542972 (Escherichia coli IOMTU792 plasmid pIOMTU792 DNA, complete sequence) position: , mismatch: 6, identity: 0.778

ccgcaccagcggggatgaaccgtagga	CRISPR spacer
ccgcgccagcggggataaaccgtgttg	Protospacer
****.***********.******.  .

47. spacer 1.16|40592|27|NC_016786|CRT matches to NC_013210 (Acetobacter pasteurianus IFO 3283-01 plasmid pAPA01-011, complete sequence) position: , mismatch: 6, identity: 0.778

ccgcaccagcggggatgaaccgtagga	CRISPR spacer
ccgcacacgcggggatgaaccgttcag	Protospacer
******  ***************  ..

48. spacer 1.16|40592|27|NC_016786|CRT matches to NC_017136 (Acetobacter pasteurianus IFO 3283-12 plasmid pAPA12-014, complete sequence) position: , mismatch: 6, identity: 0.778

ccgcaccagcggggatgaaccgtagga	CRISPR spacer
ccgcacacgcggggatgaaccgttcag	Protospacer
******  ***************  ..

49. spacer 1.1|39632|28|NC_016786|CRISPRCasFinder,CRT matches to NZ_CP017244 (Rhizobium etli 8C-3 plasmid pRsp8C3c, complete sequence) position: , mismatch: 7, identity: 0.75

gcgtcgatgatgtctttttcgatggtgg	CRISPR spacer
acgtcgatgatgtccttttcgaggtcct	Protospacer
.*************.******* * .  

50. spacer 1.1|39632|28|NC_016786|CRISPRCasFinder,CRT matches to MN871474 (UNVERIFIED: Pseudomonas virus Pa-oumiga, complete genome) position: , mismatch: 7, identity: 0.75

gcgtcgatgatgtctttttcgatggtgg	CRISPR spacer
gcgtcgatggtgtcgttttcgatctgac	Protospacer
*********.**** ********   . 

51. spacer 1.1|39632|28|NC_016786|CRISPRCasFinder,CRT matches to MN871471 (UNVERIFIED: Pseudomonas virus Pa-V, complete genome) position: , mismatch: 7, identity: 0.75

gcgtcgatgatgtctttttcgatggtgg	CRISPR spacer
gcgtcgatggtgtcgttttcgatctgac	Protospacer
*********.**** ********   . 

52. spacer 1.1|39632|28|NC_016786|CRISPRCasFinder,CRT matches to MN871472 (UNVERIFIED: Pseudomonas virus Pa-X, complete genome) position: , mismatch: 7, identity: 0.75

gcgtcgatgatgtctttttcgatggtgg	CRISPR spacer
gcgtcgatggtgtcgttttcgatctgac	Protospacer
*********.**** ********   . 

53. spacer 1.1|39632|28|NC_016786|CRISPRCasFinder,CRT matches to NC_006569 (Ruegeria pomeroyi DSS-3 megaplasmid, complete sequence) position: , mismatch: 7, identity: 0.75

gcgtcgatgatgtctttttcgatggtgg	CRISPR spacer
accatcctgatgtctctttcgatggtgg	Protospacer
.*  .  ********.************

54. spacer 1.1|39632|28|NC_016786|CRISPRCasFinder,CRT matches to MK816297 (Pseudomonas virus PBPA162, complete genome) position: , mismatch: 7, identity: 0.75

gcgtcgatgatgtctttttcgatggtgg	CRISPR spacer
gcgtcgatggtgtcgttttcgatctgac	Protospacer
*********.**** ********   . 

55. spacer 1.4|39824|28|NC_016786|CRISPRCasFinder,CRT matches to NC_012855 (Ralstonia pickettii 12D plasmid pRp12D01, complete sequence) position: , mismatch: 7, identity: 0.75

gcttcgtggcgcgaccaccgcggatcac	CRISPR spacer
acttcctggcgcgaccaccgccgaaggg	Protospacer
.**** *************** **  . 

56. spacer 1.7|40016|28|NC_016786|CRISPRCasFinder,CRT matches to MN693198 (Marine virus AFVG_25M132, complete genome) position: , mismatch: 7, identity: 0.75

gacgcaatctcagcatcaagttgctctg	CRISPR spacer
cttgcaatctcttcatcaagttgctcac	Protospacer
  .********  *************  

57. spacer 1.10|40208|28|NC_016786|CRISPRCasFinder,CRT,PILER-CR matches to MF459646 (Erwinia phage vB_EamM_RisingSun, complete genome) position: , mismatch: 7, identity: 0.75

aatgttgtatcgtcaaattccaagatcg	CRISPR spacer
catgttgtaccgtcaagttccaagcagt	Protospacer
 ********.******.*******    

58. spacer 1.11|40272|28|NC_016786|CRISPRCasFinder,CRT,PILER-CR matches to NC_048170 (Escherichia phage vB_EcoM_Goslar, complete genome) position: , mismatch: 7, identity: 0.75

cggcgtcgaacgtttttcttcggtgccg	CRISPR spacer
aagggtcgaacgttcttcttcggtggat	Protospacer
 .* **********.**********   

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	2169803 : 2177654	10	Staphylococcus_phage(28.57%)	transposase	NA
DBSCAN-SWA_2	2231253 : 2282578	46	Vibrio_phage(20.0%)	protease,tRNA,transposase,holin,integrase	attL 2258273:2258287|attR 2269672:2269686

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>NC_016786|2169803:2177654|DBSCAN-SWA
GTTAGAGATTCCTATATGTCCACCCCGCGGCCACCCACGCCGAGCGGTTCAAAACACCTCGCGCGTCTACCACCACACCGCCACATCCATGCGCAAGGCGGGGTTCAGGGACAACGCGACTAAACTCCGACCACGCCGTTGCCACCACAATTGCCTCAGGTTCTTGCAGTTCAGGCGGCCAATGCCCCACGAGGGGATCCACCACGCGCACACGAAAACCCGCAGCTTTCAACGCATGGGCCACAGCTAACCCTGGGGAGTCGCGCACATCATCGGAACCTTCTTTAAACGTGGCACCCCATACATCGATCCGCGCGCCTGGGGTGCACAGGTTGGCCACGAGTTCACAGGTGCGCTCGCGCTGCCGCAGATTGGTGGCGTCGATAATGCTCAACAGCTCAGCAAAATGCGATGCCTGATAATCGCGAGCGCTGGCCGCAAGCCCACGGACGTCCTTAGGCAAACATCCACCACCGTAGCCCAAGCCTGCGGACAAATACTGGGAGCCGATACGGGGATCAAGGCCCATGGCCCGAGTAATGGTGCCAATATCCGCACCGGTGGCACTAGCCAGTTCCGACAGCCCATTAATAAAACTGAGCTTGGTAGCCAAAAACGCATTAGCCGCCGACTTTGCCAACTCCGCCGTAGCCAGATCAGTGGTAATCACGGGGGCGTTAATCCCCTCATAAACACGCAGAAGTAGCTGCGGATCCGTGCCACCGATCACAATGCGATCAGGGTGCAGCGTATCCGCCACCGCATGACCTTCGCGCAAAAACTCAGGATTCCACAGCAAGCGGATCTGCGGAAACTGCTGCAACAAGCGTATCGACGTCCCCACCGGCACCGTCGACTTGCCCACCACCACCGGGTGGGGCGCAAGCGTAGCAATAGTCCCCACCGCCGCAACCACGGCACTCACATCCAGTCTTGCCTGGGCAGAGGGACCATCGGTGCTCGGTGTTCCCACGCACACAAAATAGAGGTCGCAATCGCGCGCACGCTGCGGATCATCCGTCCACTCAACCGAATTCGCCGCTAGAAGATCCGCCAGACCAGGCTCAGAAATAGGCAACCGGCCTGCCGACAACTCCGCCACCCGCGCAGCGTCAGTATCAACAGCCACCACCTCGTGGCCAAGGTGCGACATACACACAGCATGCGTAATGCCAAGGTAACCCGCACCGAAAACCGCAATCCGCATGGGGACTACCGGAAGTTCAGATACGCCTTCGACGGAGTAGGTCCGCGCTGGCCCTGATACTTCGAGCCCAGCACATTAGAACCATAAGGAGCCTGCGCCGGCGACGTCATCTTAAACAACGCCAACTGGCCCACCTTCATCCCTGGCCACAGCGTGATCGGCAGATTAGCAACGTTAGAAAGCTCCAACGTGATGTAGCCGGAAAAACCTGGATCAATAAAGCCCGCAGTGGAGTGCGTGAGCAAACCCAACCGCCCCAACGATGACTTACCCTCCAAACGACCAGCAATATGCGCAGGAAGAGTGAACTTCTCCAACGTAGAACCCAGCACAAACTCACCTGGGTGAAGAACAAACGGCTCCCCTTCTGGAACCTCAACCAAACTCGTTAGCTCATCCTGCTGCTGCTTCGGATCGATATGCGTGTACTTAGAGTTATTAAATACACGGAAGAGTCGATCCATACGAACATCAATCGACGACGGCTGAATCAGGTCGGCGTCGAAAGGCTCAATGCCTAACTCTCCAGCATCAATAGCGGCACGAATGTCTTTGTCGGAATACAACACGCCGTTTAGTGTACGCGATGGGAAGTGCTATCATAATGACGCTACTGAAAAATAGCGCTGCCGATGTAGTTCAATGGTAGAACATCAGCTTCCCAAGCTGAATACGCGGGTTCGATTCCCGTCATCGGCTCCACTTAGACGTCGGATTTGATAAGTACCCTTTTGCGTGGGCGGGTTTGGGTTTTGGGGTTTAACTCGCTAACGGATGGCAGGTGGCGTTCGCTGTAGTGCTTGTGATGGTGGTTCTATTTCTACTTTTGAATCGGATCTATTTGCGTTGCCCGTGTTTGGCTTTTAGTTAAGTTCTACTCTGTTGTATATGTAAGTAGCGGTGAAAAGTAGCGCAATGATTAGCAGTAGGCTGCTGGTGATTGGCCAGCCCCAAGGCGCCTTGAGTGTGTCTTGAGCGAGGTTGTTGATTATGGGGGCGAGGCCAAGGGGAGTTTTGTTGCCCTCCTGGATAAATATTGCTGACATCGTTATTAGTAGATAGGCTCCAAATCCGGCCGCAAGTGGCATACCGATGCTTGGTTTAAAAGTGGCTGCGACAGTCTGTATTACGTGAATGAGAATGATTTGTAACGCCCATACCAAACTAGCCAATATGATCGGGGCGGGATTGGCGCCTGGGAATAACAGTGATGTTCCGGCCCACGCTAGGGTAGCGCTGAAGAGGGCAAGGAATAAGGTAGATAGCCAGCTGCTGATAGCAAAGCTGATGAGGTAGTGTGAGCGCTGCACGCTACCAGGGAAAATAAAGGGAATGTCACCATTGCCGGTAAGCGCGCTGCAACGAAAAGAGTTCATTGCAATGAGGATTACGGTAAGAATTTGGGTAAGGTTCTTTATCCATCCCGCGTAGGCTTGCTGCCAAGAAGGTTCTGGTAGCGACTGTATTAGCGTGGTTACTTCTGATCCGGCCAGAAATCTGATGATTCGCGGCGTGTATTGGGTAAACAATCCTTGGGTGAGAGCAAGGATAACGAATACCCCGCCTATAATCCATGTCCCATAGGAGCGTAGGAGCCAGACAGCTTGATAGCGCCAGATCAATCTGAAACTCGAGGTATTCACGATTTTTTACTGCCGTCCTTAGTTAGTTTGGTGAAAAGTTCATCTAAGCCGCTAAAGGTGGGGTGAATCTTTGCGGCAGAGTCGAGGCTGTAGATAGCCTTAGCCACGGCGGTGGCAACGTCTGAATGCACCGTGACATCAAGCGTAACGTGTTTTGTTTGCTGACTGACTAGCTCGCCTAACTGTCCTTGAGCTAGCAGGCTACCGCGATGCAAGATCCCCACGTGGGTAGAGACTTTAGCGACATCGCTGAGTATGTGGGAGGAAAATACTACCGTTACCTCCCCGGTTAACTCGCGTAGTAGCCCCAGAACATCTGCTCGCCCGATCGGGTCAAGAGCGCTGGTTGGTTCGTCTATCAGTAGTAGTTTCGGGGTAGCAACGAGTGCTGCTGCTATTCCCATCCGTTGCTTCATGCCTCTAGAGAAGGAGCCGATTCTTCCGGGGGCTTTGTCGAGGTTCACCAGATTGAGTAGTTCGTCGCTTCTTTCGGCTGCAAGGTCTGGGGAGATTCCACCAAGGCGGGCGAGAGTGATGAGCGCGTCCTTGGCTCGAAGCCAGGGGCTAATCTGGGGGACATCAGTCAGGTAAGACACGCCTGGGATCGGTTTGACCGGAAATTTTCCTCGACTAACTCCCAGCACGGTGGCGCTACCGCTACTGGCTCCGGTCAGTCCTGCAAGGATCCTCATGGTGGTGGTTTTACCAGCCCCGTTCGCTCCCACAAACCCATAACAGGAGCCGGTAGGAACTCGAAGGTTTATGTTGTTTAGTACTTGGTGCTTACCGAAGGTTTTGGACAAATCTTTAGTAGAGACTGCTAAATTCATGTTCGTTCCTTCGGATACAGCTTGCTTACCACTGAACTCGCATCAACCTGGTGATGTTTGGCTGTAGCCTTCTGTTCGTATTCACGCTGCACTTTAAGCTGCCTTTGTTCGTGAAGGTACATAACCAAAAAGACGATTGGCCCAATCACTTGGCCAAGAGGGTGTCAGGTGTTTTGTGTGTGAGGCTCTGATCCAGAAGGAGTTTCACTGATAATGACTACCGTGTCACCGAGGAAAGGTCATGACCCGAACAGGGTCAACGAGATCAGCGCTAAGCTGATGGAAAATCCGGAAATCGCCGAACTGATCGGCGAGTTGTCGACTTCCACCGATGATGCCAGCGACCTGGTCAAAGGTCTTTTGCAGGCATCGATCAACGCTGGTCTGCAGGCTGAAATGGACGCGCATCTGGGATACGCGCACTCTGATCGTACGGCGAAAGCCCAGCTGGGCACCCCGGATGGTGGCAATCACCGCAACGGGTCGTACACCAAAACCGTCAACTCTGGCTACGGCACCTTTGATGTGACTATGCCCCGGGATCGAGCTGGCACGTTTACGCCGCGGATGCTGCCTAAAGGCACCCGCCGTCTGACGGAGCTTGATGACATGATCATCTCCCTGTACGCCGGTGGGATGACCGTGCGCGATATTCAGCACCACCTCGCCACCACCCTCGGGGTGGATATGAGCCCAGATACGATCAGCACCATTACCGACGCGGTGTTAGAAGAGGTCATGATCTGGCAAAACCGCCAGCTCGACGAGTTCTACCCAGTGATCTTCCTCGACGCGCTGCGAGTGAAGATCCGCGATGGCCACCGCGTGGTCAACAAGTCTTGCTACATGGCGGTAGGCGTCGACATAAACGGCATCAAGCACATTCTGGGATTGTGGATCGCAGACAATGAAGGCGCCAGTTTTTGGGCATCCGTGTGCGCTGACCTTGCCAACCGTGGGGTCCAAGACGTGTTCATCGTCTGCTGTGACGGGCTCAAAGGCCTGCCGGAAGCCGTGGAGGCAACCTGGCCGAATTCCATGGTGCAGACCTGTATCGTGCACCTGATCCGGGCGGCCAACAGGTGGGTGTCCTACCAAGACCGCAAACCCGTATCAAGTGCGCTACGGGAGGTCTACACCGCACCGACCGAGGACACCGCCCGCGCCGCCCTGGACGCATTCGAGGCCAGTGAACTGGGCCGTAAATACCCGCAATCGGTCAAAGTCTGGCGCGACGCCTGGGACCGGTTTGTGCCATTTTTGCAGTTCCCGCCTGCGGCACGGCGAGTACTCTACACCACGAATTCGATCGAATCGCTGAATGCTGAGCTGCGGAAAGCCACCCGCAACCGCGGCCAGTTCCCGAACGATACCGCGGCGCTGAAAACGCTGTGGCTGATGATCTGCAACATCGAGGACAAGCGCGCTGCCCAGCGAGCGAAGAAAGCGAAGCGCGCCATCGAATGCAACGGCTATATTGAAGGAGCGAAAGCCACCGGGTGGAAACAAGCCATCAACCAACTAGCCGTGGCTTACCCCGACCGATTCGCGGACTACTTGTAAACCAAGCCCCCGCACACAAACAATCGGACACCCTCCTTGGCCAAAGATGATAACCAAGAGCCACACTAGGCGATTTAAGCCGGCAATGTGAGCTCGCTTATCGCGCAGTAAGCAAATCAAAGACCAGACTACCGCTGCCAGTTGCACTCCTATAAGAATGCAAACCCCTATCAATGCTGGGGTCGGCAAATCCAACAGTTTATCTATAGGGTTCATTACTTGCCTCCTGAATTATGCAGCCGGGTTTTCACCCTGGCTAACGCGGTTTTTACATAAGCGAGTTGGCAAGCGCCAGCAACGAGGGGCCATAAAGCAACAATGGTCACCATCGACCGGCGGCTCATTTCCTGCTTGTCGCCAGCCCGGGCCACTGCTGCGAGCCAGGCTATGGACATGGCTTCAACGCCCATCAGATCAGCCTGATTAGCCAAACGCACGGCATCTTCGGATTCTGGGTCATCGCGTCGAAAGACCTGTGGCGCTAGCGCTGCAACGGTCGTTAAAACCACTGGAGCTAGCGCAGCCTGCCTGCCGGTAATAAAACTTTCAGACCCGCCGCGTGTTGAGCGCTGGACGAGAACCTGCTCCTTGCTACTGAGCAGTACCGCCAAGAACCCAACCCAAATCCCACCGGCAATAGTGGTGAGCTTAATGCCGCGCTTTAGACGTGTGGGGACGTAGCCGGCCAAGTCCGGTAGAGAATCATCGGGCCGAATTAGCCCTAAACGCACCCCAACAGCACCCAGATTAACGTCCCAACCCAGTCCGTATTTTCGAGGAATGAACAAGCGCGGATTCTCTGGTTCAAAACCATCCAGCGCAGCATCAGAGCGCCCCAACCACACCCCGGAGACAGGTATCCCCAAAACTCGCGTCTGCCCTTCTGCGTCCTTACCGAACCACTTCATTACCGTATTCCTTTCTGCGTTGTTCGCTTCACAGCACAATCAAGCGCCTCCCACTCGCGGCGCATCTGCAATAAGCGATTCTTCCCAGGTTTTGCGAGCTTATAAATCTTCCTCGGTGGCCCTACCGGAGACTCCTCCCAAGCCGTAACTACCAACCCTGATTTACGTAGACGCGCAAGCAGCGGATATAACGTACCCGTCGAAATCTCCAACCCCGCTTCCTCACGAAAACGCTCTACAAGCTGCCCCCCGTAAGAAGGACGAGACGAAAGCAATCCAAGGACAATCAGTTCAACAGCGCCCTTGCGTAACTGCGACTCAGACACAACCCCCTCCTTGCTTAACCATGTTCCTTGTATAACATACTACCGCCTGTCCAAAAGCCTAGCAACTACTTTTTCGCTAGGACTGTGATGTCTAGTGACTTTTGGACTCTGGCTTCTTGACAATGTGGGGATGGCAATTCCCATTACTCTCCGCAAGAAGATAGCGGATTTCGACCCCATCCGTGAGGGCATCACAGTCAGCAGTTCTGCAAGAACATCGGCGTATCGAAGCAGACGTACTACAACATCAAAGCGGCTCTTCCGGTTTTAGAGTGCGGATTCCAGATGATCGACGCGACAGCGACCAACGTGTGGGCTCGTCAGTAGGTGTAGACCCGAGGTTGTTGCCTCCAGCGGTCATCGTCGAGCGCGCTCTGGCGCGAGTGGCAGGGCTTGCACAGGCTTTGCAGGTTGTCGAAGTTGTGGGTGCCGCCGTGTTCGATAGGGAGGACGTGGTGAACTTCCTGCACGGGTGTGTAGCGACCGGCCTCGAGGCAGTCTTCGCAGAGCGGGTGGGCGGCGACGTAGGCGGCGCGGATCTTGCGCCACCGTGAACCGTGGCGGCGGTTGATCTTCGGATCACGCTGATACTTCCGATACCGGGCGTCCTCTGCCTTGGCCTGGGCGTCGCAGTAGCGTTCGTGTGTGAGCTCGGGGCAGCCGGGGTGGGAGCACGGGGACGCTGGTTTGACCGGCATCGCTGGCTCCTTCCCGGACATAGTGAAGCCCCAAGTTCTGGGTGCGGGTCTGATCTTCGCCGTATTCGTGGGTCTTGGACTGGGTGTATCCCTGCTCAGCAAACTTGGCGTAGAGGAACCAGCGACCCGACTGATGGAACTGCACGTGAGCATCACGTAGGATCCGGTTGAGCTTCTTCGCGGAGAGTCCGTAGTCCTTCGCAATCGCGATCGTCGTCAGGAGTGAATCGGACTGCAACACGAGGTCGTAGTACGAGACTTTCGGTGCCGCCTCCAACAAGGCTTTGCTCGGCCCGCAGCGTGGCGATGGCATGCTCCAGGAACTCATCGTCAGCGAGGAGGTCGTCGTATGCGTACACGCCATGGCGGCGAATCGTCGGCAGCACTTCATCGAACACTCATGCTTCGAACTTCTGTACTGCCGGGAGTTTGGAGGAGATGATGAGGCGGTAGAGGTCACCTTCGGTAATGAAGCGGACCTGCTGGATTCCGCCAGCGGTCTCAAGGGGGTAACGAAATGGAACCCCCTTGCAATGGTCTTGGACCGCCTTGCTGGCGTTAACGTAACCGAGCGCAGTGGCGACGTCCTTTCCGCAGAAAAGGATCTGGCCATCGTTGGTGATGGTGCGGATGGTGCCGAACACGTCGTTGGTGAATGTTTGAATCTGGTTTCCCAT

Protein sequences of DBSCAN-SWA_1

>NC_016786|2169803:2177654|2173695_2175045_+|WP_014301834.1|transposase|DBSCAN-SWA
MTTVSPRKGHDPNRVNEISAKLMENPEIAELIGELSTSTDDASDLVKGLLQASINAGLQAEMDAHLGYAHSDRTAKAQLGTPDGGNHRNGSYTKTVNSGYGTFDVTMPRDRAGTFTPRMLPKGTRRLTELDDMIISLYAGGMTVRDIQHHLATTLGVDMSPDTISTITDAVLEEVMIWQNRQLDEFYPVIFLDALRVKIRDGHRVVNKSCYMAVGVDINGIKHILGLWIADNEGASFWASVCADLANRGVQDVFIVCCDGLKGLPEAVEATWPNSMVQTCIVHLIRAANRWVSYQDRKPVSSALREVYTAPTEDTARAALDAFEASELGRKYPQSVKVWRDAWDRFVPFLQFPPAARRVLYTTNSIESLNAELRKATRNRGQFPNDTAALKTLWLMICNIEDKRAAQRAKKAKRAIECNGYIEGAKATGWKQAINQLAVAYPDRFADYL
>NC_016786|2169803:2177654|2176858_2177305_-|WP_158307717.1|DBSCAN-SWA
MSSWSMPSPRCGPSKALLEAAPKVSYYDLVLQSDSLLTTIAIAKDYGLSAKKLNRILRDAHVQFHQSGRWFLYAKFAEQGYTQSKTHEYGEDQTRTQNLGLHYVREGASDAGQTSVPVLPPRLPRAHTRTLLRRPGQGRGRPVSEVSA
>NC_016786|2169803:2177654|2171872_2172652_-|WP_014302475.1|DBSCAN-SWA
MNTSSFRLIWRYQAVWLLRSYGTWIIGGVFVILALTQGLFTQYTPRIIRFLAGSEVTTLIQSLPEPSWQQAYAGWIKNLTQILTVILIAMNSFRCSALTGNGDIPFIFPGSVQRSHYLISFAISSWLSTLFLALFSATLAWAGTSLLFPGANPAPIILASLVWALQIILIHVIQTVAATFKPSIGMPLAAGFGAYLLITMSAIFIQEGNKTPLGLAPIINNLAQDTLKAPWGWPITSSLLLIIALLFTATYIYNRVELN
>NC_016786|2169803:2177654|2171014_2171578_-|WP_014302474.1|DBSCAN-SWA
MLYSDKDIRAAIDAGELGIEPFDADLIQPSSIDVRMDRLFRVFNNSKYTHIDPKQQQDELTSLVEVPEGEPFVLHPGEFVLGSTLEKFTLPAHIAGRLEGKSSLGRLGLLTHSTAGFIDPGFSGYITLELSNVANLPITLWPGMKVGQLALFKMTSPAQAPYGSNVLGSKYQGQRGPTPSKAYLNFR
>NC_016786|2169803:2177654|2172648_2173482_-|WP_014302476.1|DBSCAN-SWA
MNLAVSTKDLSKTFGKHQVLNNINLRVPTGSCYGFVGANGAGKTTTMRILAGLTGASSGSATVLGVSRGKFPVKPIPGVSYLTDVPQISPWLRAKDALITLARLGGISPDLAAERSDELLNLVNLDKAPGRIGSFSRGMKQRMGIAAALVATPKLLLIDEPTSALDPIGRADVLGLLRELTGEVTVVFSSHILSDVAKVSTHVGILHRGSLLAQGQLGELVSQQTKHVTLDVTVHSDVATAVAKAIYSLDSAAKIHPTFSGLDELFTKLTKDGSKKS
>NC_016786|2169803:2177654|2177375_2177654_-|WP_014302480.1|DBSCAN-SWA
MGNQIQTFTNDVFGTIRTITNDGQILFCGKDVATALGYVNASKAVQDHCKGVPFRYPLETAGGIQQVRFITEGDLYRLIISSKLPAVQKFEA
>NC_016786|2169803:2177654|2175260_2175953_-|WP_014302477.1|DBSCAN-SWA
MKWFGKDAEGQTRVLGIPVSGVWLGRSDAALDGFEPENPRLFIPRKYGLGWDVNLGAVGVRLGLIRPDDSLPDLAGYVPTRLKRGIKLTTIAGGIWVGFLAVLLSSKEQVLVQRSTRGGSESFITGRQAALAPVVLTTVAALAPQVFRRDDPESEDAVRLANQADLMGVEAMSIAWLAAVARAGDKQEMSRRSMVTIVALWPLVAGACQLAYVKTALARVKTRLHNSGGK
>NC_016786|2169803:2177654|2176599_2176977_-|WP_014302478.1|DBSCAN-SWA
MPVKPASPCSHPGCPELTHERYCDAQAKAEDARYRKYQRDPKINRRHGSRWRKIRAAYVAAHPLCEDCLEAGRYTPVQEVHHVLPIEHGGTHNFDNLQSLCKPCHSRQSALDDDRWRQQPRVYTY
>NC_016786|2169803:2177654|2169803_2171009_-|WP_014302473.1|DBSCAN-SWA
MRIAVFGAGYLGITHAVCMSHLGHEVVAVDTDAARVAELSAGRLPISEPGLADLLAANSVEWTDDPQRARDCDLYFVCVGTPSTDGPSAQARLDVSAVVAAVGTIATLAPHPVVVGKSTVPVGTSIRLLQQFPQIRLLWNPEFLREGHAVADTLHPDRIVIGGTDPQLLLRVYEGINAPVITTDLATAELAKSAANAFLATKLSFINGLSELASATGADIGTITRAMGLDPRIGSQYLSAGLGYGGGCLPKDVRGLAASARDYQASHFAELLSIIDATNLRQRERTCELVANLCTPGARIDVWGATFKEGSDDVRDSPGLAVAHALKAAGFRVRVVDPLVGHWPPELQEPEAIVVATAWSEFSRVVPEPRLAHGCGGVVVDARGVLNRSAWVAAGWTYRNL
>NC_016786|2169803:2177654|2175952_2176279_-|WP_010935617.1|DBSCAN-SWA
MSESQLRKGAVELIVLGLLSSRPSYGGQLVERFREEAGLEISTGTLYPLLARLRKSGLVVTAWEESPVGPPRKIYKLAKPGKNRLLQMRREWEALDCAVKRTTQKGIR

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014302473.1|2169803_2171009_-	UDP-glucose/GDP-mannose dehydrogenase family protein	A0A127AXI2	Bacillus_phage	3.2e-51	36.9
WP_014302474.1|2171014_2171578_-	dCTP deaminase	I4AZP2	Saccharomonospora_phage	6.6e-76	72.6
WP_014302475.1|2171872_2172652_-	hypothetical protein	NA	NA	NA	NA
WP_014302476.1|2172648_2173482_-	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	9.3e-26	35.2
WP_014301834.1|2173695_2175045_+|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	1.4e-34	36.6
WP_014302477.1|2175260_2175953_-	hypothetical protein	NA	NA	NA	NA
WP_010935617.1|2175952_2176279_-	PadR family transcriptional regulator	NA	NA	NA	NA
WP_014302478.1|2176599_2176977_-	HNH endonuclease	A0A2H4PHY5	Pseudomonas_phage	2.1e-09	45.1
WP_158307717.1|2176858_2177305_-	phage antirepressor KilAC domain-containing protein	A0A1Q1PVZ8	Staphylococcus_phage	1.6e-16	51.2
WP_014302480.1|2177375_2177654_-	Bro-N domain-containing protein	A6XMM0	Bacillus_virus	1.5e-17	50.5

Sequences of DBSCAN-SWA_2

Nucleotide sequences of DBSCAN-SWA_2

>NC_016786|2231253:2282578|DBSCAN-SWA
CTTAGGAGAACAACGGTGGAGTTGCACCATCGCTCAGGTCCGAGGAACCGGGCAAATCACTATGCATGTGCAGGAATTCGAGGTGACGCTCGTACAAATCCAGCACGTTGTCGATGAGCTGTTCCTGGGTATAGCCGTAGATGTCGTACCCCAAAGAACCGGTCAGGTCACACACCTCAAGGCGGTAGTAGGTTTCCTTCTCCGAGGCATTGGCCTTACGGGTGAACTGCGGCACGGGATTGCACACAGGGAACAGCTGGTAGCGGAAGTTTTGTTCGGAACCCATCTCCACGATCAGGTCCAAGCCCTCAACTGCCTGCGTCTTTGTAGTAACCAACCGCGCGTTGATTCCCTTGCGGCACAACTCTTCAGCCACCTGCGTGAGCGCCGGCGTTGCCACATTGGTGATGTACGCCTGCGCCTTAGCAGCGCTCGGCCAGGTGTTGGCACGGCTAAGACGACGACGCCACGAAATAGAGTGTCCCTGCTGCTCACCGATGGTGCTACGCCCCGACATGGCAGCATGGACCGACACCACGCGAGCGTCCTTTTGGGTTTGCTCCAATCGGAAACAGCGCACCAAACCGGCCATGACCAAGTAGATCACGATGGTAAACGGCAGTCCCATCACCACGGTAGCCGACTGAACGGTAGCAATACCGTCGAGCTGCAGCATCACAATGGTGAGCGCACCGACAACCACAGCCCAGAAAATTCGGGACCATACTGGGCCGTCTTGACTGCTGTGGTGAGTGGTGGAGGTGAAGTTACTCATCACCAACGCACCGGAGTCAGCAGAGGTGATGTACAGCAGCAGACCGATCATGGTGGCCAGTCCCACGAGGAAGATCGCACCTGGGTAGGTGGCCAGCAGATCGTAGAAGCCACGCTGGGGGTTAGCGGCAGCCTCGTGGCCGAAAGCATCGTTGCCGCCGCGCACGATGGCGAGTGCGGAGTTACCAAAGAAACTCATCCACAACACAATGAACAGGAAGGGGATGCTCAAGGTGCCGAACACGAATTGACGCAGCGTGCGGCCGCGGGAAATACGGGCGAGGAACAGTCCCACGAATGGCGCCCAAGCCACCCACCATGCCCAGAAGAAGAGGGTCCATGCACCCAACCATGCCTTGGTATGCTCCGGGTCGTCGGAAAACGCGTAGGTGTCCATGGTCATCCCCGGTAGGGAGGACACGTAGTCGCCGATGTTCATCACAAGACCGTCGAGCAAGAAGGCGGTTTTACCTGCGATGACCACGTAGATCATGAGGGCGATGGCGAGCAGCACGTTGATTTCGCTGAGCACTTTGATGCCCTTATCCACGCCGGATACCGCAGAAAGCGTTGCGACGGCCACCGATACCACCACAAGGATGATCTGCCAGGTAGGGCCTTCTTCTACCCCAAAGAGTACTTTCATACCGTAATTCAACTGCACCACGCCGATACCCAGCGAGGCTGCGATACCGAAGATGGTACCCAGCATGGCGGCAATGTCTACGCAGTTACCCACCGCACCGTGAATGCGTTTGCCGATCAACGGATATAGTGCCGAGCGGATCGCCAGTGGCATGTTCAAGCGGTAGGCGTAGTAGCCGAAGGCCATGCCCATGAGGCAGTACAGCGCCCAGCCGGTCATGCCGTAGTGGAACAGTGCCCACACCACGGCTTGTTCCGCAGCCTCACGCGTTTCACCCTGGCCAACAGGCGGGCCATAGTACTGGGCCACTGGTTCTGCGACGGAGAAGAACATAAGATCCACGCCGATACCGGCGGCAAACAGCATGGCCGACCACGAGAAGAGTTTGAACTGTGGGCGGGAGTGATCGGGACCTAGGCGGATGCTGCCAGTTCTAGTGACGGCAACACCGATAACAAAGACGATCACCACGGTGGCGGTGAGGATATAGAACCAACCTAGGTTGGTAGAGATCCACTCGGTGACAGCACCGAGTGCCGTGGCTGCTTTTTCACGGGCGAAGAATGCCCAAAGGGTCAGCGCAATAATGCCCACTGCGGATGCGCCGAATACGGGCCAGTTGGTAGTGGGTTCGGGGATGTCATTTCCGCCTGCGGAACTCTCACCAACAACTCCCCCCGCGCCGGCTTTATATGAACCGACCAAAACTTTTGGCGCGGCTTCCTTTACCCCCTGCATTTTACCCCCAAGTGAGGTTGATGCGTCCACCGAGGACGCGTCACCATCTGTGTGAGCATCTTCTTTCACGCCGTGTCACCTCTTCTTATCGTCTACTCATCATCATTGCTGTTGCCGGAGTCAGTGTTTCGCCATGTGAGACAGCAGTTTTGGCTCACTGGTTTTTTAGACAAAATTACGGTTTCTAAGTCGCATTTTTGCCTGTTTGCACCGTGTTCATTCTCCGTCACATCACTGTCGACACTACACAGCGCAGGACTTTTTGTGTGGCAGCAATCTCAACTCGCTGGCACACTGGATAAAAGAAGAAGCTGATAAATCTGAAAGGAAAAGGAGATATATGAGTCTACGAAACCGACTCCGCACCTCAATTTCTAAGCACGACACAGACGGCGAATTTATTCAAGATCGGACACGCGATGTGGTTATCGTGGGTGGCGGTTCCGCCGGCTCCGTGCTCGCCAATCGCCTCTCCGAAGACCCCGACACAAGCGTGATGGTGCTGGAAGCCGGTCGCTCCGACTCCCTGTGGGACCTATTCATCCACATGCCCGCAGCATTCTCCTTCCCCATCGGCAACAAGTACTACGACTGGGCTTATGAGTCCGAGCCGGAACCACACATGAACGGCCGCCGCATCTACCACGCCCGCGGCAAGGTTCTCGGCGGCTCTAGCTCCATCAACGGCATGATCTTCCAACGCGGTAACCCTATGGATTACGAGAAGTGGGGCGCGTTGCCAGGCATGCAGAACTGGGACTTCAAGCACGTGCTGCCGTACTTTAATAAGATGGAAACCGCACTGGGTGCCGATGCTAACGATCCCCGTCGCGGCCACACCGGCCCACTGAAGCTCACCCGCGGCCCAGCTACCACCCCGCTGTTCCAAGCATTTTTCCGTTCCGTTCAAGAAGCCGGTTACAACCTGACTAACGACGTCAACGGTTACCGCCAAGAGGGATTCGCCCCCTTTGACCGCAACATCTTGAAGGGCAAGCGCCTTTCTGCTGCTCGCGCTTATTTGCACCCAGTTATGGATCGCACCAACCTTGAGGTGCGCACTCGTGCGCTGACCACTCGGATTTTATTCAACGAGGCTGGCACACAGGCCACCGGTGTTGAGTATGAGTGGAAGGGCAAGAAGCGTCGTGTAATGGCCAAGAAGGTCATTTTGTGCGGTGGCGCCTTCAACACCCCACGGTTGTTGCAGGTCAGCGGCGTGGGCGACCGTGAAGTGCTGGAAAAGGCCGGCGTTGACGTGGTCAAGCATCTGCCAGGTGTGGGCGCTAACTTGCAGGACCACTTGGAGGTGTACGTCCAGTACAACGTGACCAAGCCAGTGTCGGTGCAGCCTAACTACAAGATGACGCGTCGTCCGTTTATCGGTTTGCAGTGGTTGCTGACCAAGAAGGGCCCTGTGGCCTCTTCCCACTTTGAGGCCGGCGGCTTCGCCCGTTCGAATGACGACGAAGCATACCCGAACTTGATGTTCCACTTCCTGCCGATGGCGATTCGTTACGACGGCACCCAGCCAGAAGGCGACCACGGTTTCCAGTTCCACGTAGGCCCTATGTACTCCGACACCTTGGGCCATGTGCACATTACCTCGCCGGACCCTAAGGCCAAACCAGAGATCATCTTTAATTACTTGGCCACTGAACAGGATCGTCGCGAATGGGTAGAAGCCGTGCGCGTCTCGCGTCGCCTCCTGGATACGGATGCGATGAAGGAGTACACCGACGGCGAGATTTCACCCGGCGCGGACGTGCAGACCGATGAGGAGATCTTGGAGTGGGTGCGTAACGACGCCGAAACTGCCCTGCACCCATCGTGTACTGCGAAGATGGGCTCGGCTGACGACGCCATGGCGGTGGTCGATCCGGAGAACATGCAGGTTCACGGTATTGATGGCTTGTATGTGTGCGATGCTTCTGCAATGCCGATTATTACTAACGGCAACATCTACGCACCTGTGATCATGATGGCGGAAAAGGCTGCCGATCTGATTAAGGGCATTAAGCCGCTGGCACCTATCGACGTTCCGTTCTACAAGGCCAAGCAGGGCATGCCGCTCTATGCCGAGGACGAAAAGGTTCGCGATCACACGAAGGCTATTCCTGGCGCTGACCACTAGCCTTCTGACACGGAACTCAGTGGCGCTGGTGGGCACTGGTGGGCGCGCCACCCCCGATCACCCCCCGAAAAGACGGCACTTCACACCAAATCTGCTCAAACGGCCGGTTTGGAAGCGATTTGGTGTGAAGTTCCGAGAAAAATCCTTCGAAATACCCCCGTTTAGGGGCTCTTTCCGGTTTAGCTGTTATTTCAGGGCGTCGACAAGCTTGTTATCAAACATCGACAATGCCGAGGCAATAGCCATGTGCATGTCTAGGTACTGGTACGTGCCCAGACGCCCGCCGAAGTACACCTTGCTGGACTCCGTCTCGGCGTCGGCAAGCTCGCGGTACTTGAACAACATCTCGCGGTCACTTGGGGTGTTAATTGGGTAGTACGGCTCATCACCCTCTTCCGCAAAGCGCGAGTACTCCTTCATAATCACCGTCTTGTCCTTCGGGTGGCGATCCTCACGCTCCGGGTGGAAGTGACGGAACTCGTGAATACGCGTGTACGGGAACTCCGCATCGTTGTAGTTCATCACAGGGGTTCCCTGGAAATCACCCGTGTTCAGCACCTCAGTTTCAAAGTCCAAGGTACGCCAACCAAGGTGACCCTCAGAGTAATCAAAGTAGCGATCCAGTGGGCCGGTGTAGACCACAGGAGCCTCAGGGTTCTGTGCGCGGAGATCCTCACGTACCTCGAACCAATCAGTGTCCAACCGCACCTCAATGTTCTCGTGATCAGCCATGTTGCTCAACCACTGCGCGTAGCCGTCGACAGGCAGCCCCTCATAAGTGTCGTTAAAGTAACGGTTATCAAAGTTGTAGCGCACAGGCAACCGCGTGATATTACCCGCCGGCAGCTCCTTCGGATCCGTCTGCCACTGCTTCGCCGTGTAATCGCGAATAAACGCCTCATACAACGGACGACCAATCAGCGAGATCGCCTTTTCCTCCAAGTTGGTCGCATCCTTAGAATCAATCTCCGCAGATTGTTCCTTGATCAACTCGCGAGCCTCATCAGGAGTGTAGTAACGGCCAAAGAACTGGTTAATCAGACCCAACCCCATAGGGAACTGGTAAGCAGTACCATTGTGCATAGCAAACACACGGTGCTGGTAACCGGTGAAAGCGGTGAACTGATTCACGTAATCCCACACCCGCTTATTAGAAGTGTGGAACAAATGCGCACCATACTTATGGATCTCAATACCCGTCTCTGGCTCCGCCTCCGAATAAGCATTGCCACCCAAGTGAGAACGCTTCTCCACAATGAGTACCTTCTTGCCCAGCTGGCTAGCAGCACGCTCAGCAACCGTCAGGCCAAACAGGCCAGAACCTACCACGATCAGATCAAAGTCAGACATGGGTATGAGTGTAGCCGGAAAGCTCAACCTTATGGGGGTTAGGCACCACAAATCCCCTCAAGCACTGCCATAATCTGCGTATAGCGCACCTCAATCTGAGGAGCATTCTTGCTAGGAATTTCTAAACGCCACACGCATCTCTCAACCGCTTGATCGTCCACATTTTTCCACCCAGCCAACAAAGCATCACGCGATTGCACGCTAAGAATCTTATTAATATCGCTTCCCAAGAGAAAACCAGCCATATTTTTCCCGACCACGATCCAGCCATGCAAACATTTTTAATGCTGCTAAACCCGACACTGTTGGCATCCGTATAGTTAAGCCATCACCCAGTTGAAGGAATTGCGCATGTTCAAACACTTCTTGTATTCCTCGTACATTGAGCTTATGCGTGTACCCACTAGACACTTCTCCGAGAGGCTCTTCGAGCTCTCCGAAAGGAATGATGTCTAGTGTGATCCCCTCAACTAAGACGGACTGCCAAGCATTGGTTGTGGAGGGAAATCGTTGTTTTAGCGCTCTGAAAGTTCCCAGTCTTCCAATGCCAATGCAAAATCTATATCTTTTGTGGCACGTGACGCTTCCCCACCGACAATGTTCTTCTGATGTATATCTCGACATCGAGCTCCTACGAGCATTATTTTCTCAGTTGAAACCACACTGCTGAGTGCCGTTACAACTCGTTTAATATCATCCATCTTGGTCCCCTAACCAGTCTCCCCTTGCGCGTTTAAGGATAATGGCTTTTATTACTTGAGCAACATCCCAAAGGCGGGCATCGTCAGAATTAAGAAGATCGGCGTACACAATCGCCTCTGGAATCTCTTTGACATCTATCGTATTCCAAAAAGCTCGTCGCAAAGTTATTGTTCCAGCTGGGTTTTTTACCAGTCTAAGTTCCTTGATCACTTTGGGTGAAAAGGTTTCTTCTCCTAGGTATAGCGAAGCAGATTGTCCATCAGAAATGTGGTCTGATACTGCGCTTTCGCTTGCCTTAACACCCAAATGTTCAAGGTTATATGGAGGCAGTTGTTGTGCTTTTCCGCGCAGCAACTCTAGATCTGCTCCCAGCCCTGTGGGATACGCACGGGCCCAAGCGCTAAGAAATAATTCCGCGTTGACTAGTCGGTGCCCGTCCATGGTTTCGGCAAGATAACCTGCTTTTTGGAAAATCTTGAGGGCGTTGCTTACGGTGCCTACGGAGACTCCCGAGTATCGGGCTATCACTCGAACTGGCTCCGACAGTAGCCATGGATACGTCAATATCATCGCGGCGACTTGGGCACGTCGCACGCTAAAAAGCACTGCGGTTTTTTGGTGGGATCGCGCACTAGTAACAGCTTGCTGACCATAGATTTTAATCATCACGCCTGGCCATGAAATATCGCAATTGCCACGTGTGTCAGCTAATCCGATATTTCTTGCCGTAAGCCGCCGTCCTACTGTTCTAGTGGCGCATGGCATTAGTATGAGCGAATCTCTTTCTGGCAGGTGAAGATTCGCTATGTCATGCTGCCACGGAATGATCTGCATATTCCGTGTAACAAGGCTTTTCTCTTGTGAATCGACTACTTCAATTTCAGCTTTTGTCCGCTCCGATCCATCAAAACTGATGTTGGGGTTGGTAAATCGCAGTGGAACATTTTTTCTTTCCATAACTCGTTCCATTGCCCCGAGCGCATGAATATTTGCGAGCCAGTTCGCATAGTGGTCATAAAGCAACCCTACAGCACTGTTCAGGAATAGTGAGCGTTCATTATTCCTGAACAGTGCTGTTCATCGCCGTGGTACGATGATGCGCCCGCATGTTTTGACCTTCGCGTTGTAGATTTTTTCTACTCGTTCAACAGTGAGGTTTCGAGTGGTGCGCATGGCGTCGATAAGTTCGAGCACGTCTTGGGCGTGTCCGATGTCGAGCACCGAGGTGGGTTCGTCGAGAAGCAAAACGTCGGGTTGTTGCACGAAGGCTCGAGCGAGGACCACGCGTTGTGCCTGCCCGCCGAATAGCCGTGCGACCTCGCGTTTGGGGCTGAGGTCGAGGGTGTCTGTCACTTCTTGGAGCAGCGCCCGGTTGACGGCTTAAGGGACAAAAAGGGGATGCGGACGAAATCTTGGAGGATTTCCCGTATGACTAATGTGCGATACACGGATGCCCTTTTGCTACTTAGGCCCCAATCCTTCGCGTCGCCAAAAAGCAGAAACCCGCCGAACAATGTCCGGCGGGGTTTCGCAATTATTACGGATTTTAACCCGTCTTATGCCGATAGTGTAAGACAGATTGCATGAAAACTGAAGTGCCCTAGGTTTTGTTCCGTTTGAGTAGATGGGAAAATCCTCGAACATGCCGAAGAAAATTTAAACTGCTTCCCATTAGTTGGACTGAGAAATCAGATACCGAATAAAGGGGAGCAGTTCACACACGTCTCAGGGGTTTCTTCTTGCCACTAGGTGCACTAGAGTTAACAAGGATTGTCTTTCTCCTCAGAAGACACACGCGCACATCACATCGAGGGAGAACACAGTGCAGCAACGACGAAGGCTGATAAGCCGCACGCCGAAACCAGTCACAGCAGCCATCATGGCCATCACCTTGGTCGGCGCAGCAGCCGTAGGCGTAAGCACCAACAGCGTGCTATTTACCCAAGGCGACGCCATCGCCCCCATCAACCCAGAGCTGACCACCTCCAGCCTTGCCGACGGCAACAACGTGCTGGTCACCGACCCAGCAATCGCCACCCAGGGCGAAGGCGAAGGCCCCAAAACCGTCAAAGAATTCCACCGCGAACAACCCTTCTCACAGTTCGCACTCACCTGGAACGGCGAACGCGACATCGCAGCCTTCGTCCGTGGTCAACGCCCCGACGGCACTTGGACCGAATGGTTCGACACCGAACCTCTCGACTATGGATCAGACAACCCCAACCATAAAAAGGGCACCGACCTGATCTACATCGAACCCACAACCACAGTGCAGGTATCCATCAGCGGCGTTGACGTCCTTGGCCCCGACGCAGCCAACTTGGACGCAGTCTTTATCGACGGCGGAACCTCCGATCTTCCCGAAAACGGCATCAACCTCACCGCCGACTCCGACGGCATGCCCCGCGTCATCTCCCGCGCAGGCTGGGGTGCCGACGAATCCCTCCGCTGCTCCCGACCAGAATACGAAGACTCCACCGCAGCTATCGTCATCCACCACACCGCCGGATCCAACAACTACAGCCAAAAAGAATCCCCCGGCATCATGCGCGGCATCTACAAATACCACGCACAAACCCTCGGCTGGTGCGACATCGGATACCACGCCCTCGCCGACAAATACGGCAACCTCTTCGAAGGCCGCTACGGCGGATTGAACAAGAGCATCGTTGGCGCCCACGCAGGTGGCTTCAACTCCAACACCTGGGCTATCTCCATGATGGGTAACTATGACGTAGTCCAGCCCCCACAAGCCATGATCAAATCCGTTGGTGAACTCGCCGGCTGGCGCGCCAAAGTCGCAGGTATCGACCCCAAGGGCTCCGACACCCACTACTCCGAAGGCTCCAGCTACACCTTCTACCCCTACGGTCAAGCAGTACTCCTGCCCAACATCTTCGCCCACCGCGACGTAGGAAACACCGCCTGCCCAGGCCGATACGGATACGCCCAAATGGACAACATCCGCAACATCGCCAAGCAGAAATACGACTCGATCCGCTCCGGCTCCGGCGCGACAGCACCCGCTGCACCGTCTACGCCATCAAAACCAGCGCCTGCACCAGCCGCTCCCGCAGCACCTTCTGCACCAGCCGCTCCCGCTGGCACTAATCCCATCGGGCTACTCAGCCAAGGCTCCACCCCTGCAAACGCAGGCTCCTTGGTCGGACTTGCCGTCGCAGCAGCCACCTCGCTCGGTCTGATCGGCAACCTTAACAACATTGGCGACGTCCCCGTCATCGGCGGGCTGAAACTCTCCCAGCTCCAGCCCATCATCGGCAAAATCGTTGAACTCCTTGGCAACAACGACGTCTCCCGTGTATGGCGCGACGTAAACTCCTTCGCCGGCGCAGCCCTCGGCAACGCCCGCTCCCCCATCGCCCACTACGCCTCTGCCACCGGCACCCCCATCGACTACGCCCTCTTTGACAACGGCATCGTGATCAGCAACCCAGAAACCGGCACCAACGCCCTCTGGGGAACCATCGGCGACCTATGGGCACAACAAGGCTTCGAAGCCGGCCCCCTAGGACTACCCACCAGCTCCGTCTTTGAAGTTGACGGCCTCCAGCGCGTGAACTTCCAACACGGCTACATCACCTTCAACCCAACAACAAGCGCCGTCGACATCCAGGTGCAGTAACAAGCACAAGCTCGCCCCAGCTGGGGCGAGCTTTTTGTTTACCGATGGTATTCCGACAATGCGGCAGTGGTGCCAGCTTAAAGAAAACGGAATGAAGAGTTCTCTTGTTTATCTATTAGCAGCAGTTCTTCGTATATCCAGCAGATCAGATATCTGCGTTAATCGGGCATCGTCAGATTCAACCACTGGTATCTGGATTTTACTGTGCAATCCAGATACGGGAAAATACCTACCGAATTTAGTTGCGAGTACTACTTGCGATTTCTGCGCCTTACTCTCATCCGAGTTTCTATGCACTACTGGGATCTTTTCAAACGCGTCTGCAGACCCTCTTCCTAAATAGAATGGGAACTCGGCATAAAATGCTTTCCTTCCCAAATAGGTAACAAAAGCAGGCGAAGAAAACGCATTTTCAATTTCATCCATATGAGTTGAGGATGTTACCCGCACAAGGTATTCACCATCGGCTAAGTAGGTCCTATTGACAATAGAAGTACCTCCTTGTGCATCAGGTGTGAACGTAAGCGCTTTCGCACTATTAGCTTTTCGCCCTTGAGCTATCAGAAGTCGCTTGCGGAATGTCTCAACTTCTGGAAGCGGATTAATAGTCTGAAATTCGTTAACAACAATCGGCTTACGATCTTCCCGAACCCAAAACTCAACGTCATCCAGCCAGTTCGGCCATTCTCCTCGACGCGCCCCTAATGCTCCTGCAAGCAACCCGCGTAGAGAGCTAAACGTTGGACGTGGCTCAGTCCGCACAATGTTTCCAGTAACAACGCTCCCCGCCCATGATTGAAGTGGCCCCGACAACCTGATATACGCCGACTCAATCATTTGTCACCCAATTCACAACAGCTTCAATCAACCCATTAAGATCAGATCTTTGCACTCCTTCGAACTGCTCATCTTCAAGTACAGCTGTTCCGGACACGACTTCCAGTGGGCCAAAGTTGCCTTTGTCAAAAGAACGAGCTCGTGCAAATTGACGATCTAGTTCACAAATCGTAGGAAACTCAAAGCCCCCATCTTTCCCAACAAGAACCGGCGTCTCAAAAGAATACGCAGTTCGATAATGTTGTTCTTCTGCAAAAACTAGGCTCGGAAGCGTATATGGAGCCGTCGAATTCTCTTTACCTCTCGGGGCACCATAGACAATAGCTTTAATTAATTCGCGAAGATTGTCTACAGATTCCTCTTGGCCAAAACCAGACCAACTTTCGCGCAATTGCTCCTTGTCAATACTTACCGTGCGATAGAAAGTTCCATTCACGTATCGTGCAACCCCCAGAAAGGTTGCGCCCGAATCATGTTCTCGCTCGCGGACGTCGTCTACCGTTGAAAAATAATCTGTTTCAATCGTAACGGCATGAGTCGTGACTCCTGGAGAAACAGCCAATGCTGCCTCTGTGTTCTTCTTTGGAGCATTCGCAAACATCCGGCCAAAAGCTGCAATCGCCAACGAACCAGTACGATTATCTTGGATAAAATCAGAGTCTTCTTGTCCATCAATTACGGTTTGTGCTGCTGTCGTAATCTCTTCCCTGCTCATCCATGCAGAACGAGCAGACTCCCCCTCAGAGGATTCGCCTTTAGTGAGACTACCGATAATCTTCGCAGCACCTTTCCTTAAGAGCTTCTCATCAACCTCTGGTTTTAAGTCCAGACCAACTCTCACAACCTCTTCGACCAACTTTCCTGATCGGATTGAGGTATCAAGACTAGCAAGTTCATATTTTGTACGAATGCCCCTCTTGATGCTTTGAGAAGAATGAAGGGCTCGCAGAGCACCACCAAGCGACACTCTCTTAGGCGTACCTGAATCGTCTCGGTTCAAATTGGAGTATGGGACATTTGTAATAATGTGAAACGTGAGATGGCGTGACATATTTTCCTCTCTCCTGTCGATATTTTTATCGGTCATTAGTGTGTCTGTCGATCACTTATTCAATAAGGCTGCCGAAAGAACCGTAGTAATCTTGCAAAACTCGCATTCTTACCCTTTGAGACTTCTCACTAATTCCATTCCCCCAGTATGAAAACAAAGAATAGAGGGCAATGTAATCAAATGCCGGCACGTTACTCAGGCTTGATGCAATACTCATCAATCTGGAAACTGCGCGTACAGCTTCTTCAAAATCCTGTGTATGAAGATACGCAAGCCGTTCTCCAACAACATCAAGTTTCTTCGGATTAAAAGCAACCTGCTGTTGGCGATCCAACATACGTTGTCGTGATACTTCGTATGCCCATCGTCCAAGCGACTTAGCTGGGGTATCAGAACCAACAGCAGGTATATTGCCAAACTCTGCAGCAAGAGCCGCTACCCTCATCAGCACAAGACGCTCCTGCGTTGTTGCTTCTTGTGGAAGCTGCGGGTACACGTAGGGAAAAGCATATACCTCAGTCGTAGTATCCGCTCCACGACGCAGATTCGCTCGGGTCTGACGGTATTCTTTCTCTTCCCGTCGGCATAGCACTTCATGTAAGAAGCACTTCCCTGAATTTAAAACCAGTTTTTCACTCATTCGATTCTTCCTTTATCCGACCGATACCTTCATCTCGCGCAGTATTAATCTTGCTGTTGACACTTCGCACTAAGCTTGCCCTGACGTAATAAATTTCATTTGCATACTGAGCAAGATACGGAGCTGTCACTTCGTCATATGCTTCTAGAGCAGCACTCCGAATTCCCCGGTAAAGTTCCTCCGTTATTTCTTCCCCCACCCTAAGATCAGCTAGATACTTTTGGTAAACATCGGTAACACCACGCCAGTATGCATCAGATGCGTCGGACTGACTTACGGCAAGAGAGTCGAGTACCGCCGCACCCCACCCTGTTGCGACTTCCCGACTAGCATCGGCTGCACTCTTTCTCCGAAAAACCCCAAGAAGCGTGATATACACGTCACGGACTAGTTGCGCATTGTCTCGGAGGCGAAGCTGCTCATCACAAGATAGATCAAATGCCCAGACAGACCGATCTGCTAAGAATACCTCTGACGCTCTAATCGATGGTGATGAGGCAGTCCCTTCTACTTGGTGCCGGAAAAAAACCAGCTGATACTTGTCGATTCCTTCATCGTCGCCATCTACCGTTGGGTAACTATCTACTGGAAGCACATTCTTGTAAGTTTTTTCTACAAGATCCATCATTTTTGCTTCTGCAGCCCACTCAACCGCAAGATCAATACCATCTCGCCCAAAATCGATACGCTGAGCTTTTGGCTCTCCCTTCTTATTTTTAAGGTAAAAGTAAAGTGGATCTTTCTCATTGCGTTGATCCCACCAGAGTTTGAGTGCTTTCTCACCCTCTTTGGTATTAGGTATATCTGGCCACCAAGCTGGGGGAATACCTCCTACACGTACACCTGTAAGGTAGCCATCCTCCCAATATGAGACCACAGTGTTGGAACTCCAAGTTGCTTCCCATAAAGCATGAAACTGTTGCTGCCCCGTCCTTGACTTCTGTGCAGTCCGATCAGCCCATGCAGGCAATCCCTCCCCCTTAACCCAAGAAGTAGGAAGTGACGTTAATAGCGACCGAAGCAAGCTACTACCTTCACGGATCCAAATATGCTCAGTAGCTGCGTACCCCTTCCCAGGAAAACGAATCCCAGGTGCTCCCATGCGAGTCTTATCACCATCAAATTTATTATTCCCCGCCATCGAAAAATAGTGATAGGTGACAATTTTCAGAGTCGCTTCAGAAATGCTCAAAGAATCGGGAAATTCAACAAGCAAGTTCCAATAATCTTCACCCTGCTCGGACGGCATCGCAGGAGAAAGCTTTTTCACTTCTTGGTCGCCAGGTCCTATCCGACGTGATGCATCTTTCGGCCCTTCTGGATGCAATCTTGGCCTCCCCATAAAAGGCTGAAGCCCATCCAGCACGTTAAGGTGACTAACCAAATTTTGATTAACCTTCTCCACCACTGCACTGGAAAAACCATTTTGCAGTAGTGATTGCGTTTGCTCCAGAGACGGAGCTCGACCGAATTCTTCTCGAACTAACAGGGCAGTAACACTAAGAAGAAAGCGGAATTGCGCAGATATCTCGAAACCAGGAAGCGACATGTCGAGAGAAAAACCTGGTTCATGACACCGAGACAAAGCTTCCTTCGGAGTAACTAATCCCGCGGTAGTACGGATCCAGGCTATGTCAGAAAATGCATTTGCTTTCATACGGTTGCCGTTTCTTGTCGTAACAAGTTCATAAAGTCAGAGTAACCAAACTAACCGGTTCAAATCAATGGAAGTACAGAATTATTTTTAACTATTGTAAATTACGTCTTCAATTTGTACGATGATAGAACACATGGGTTGAAGCAATAAATACCCCCGCCAGCGCGGGGAACAACTTTTGTAGATTACAGAAATACCTCCGCACACACGGAGATCCATGCTCTGCCCCGATAGTATATGGCTAGGAGATCGCTTAAATGAATACGAAAATTCACCTCGTAAAGCTACCCGTTCACATAGCACTCTCTGTACCTGCGAAAAACAAACCTCGTAAAGGATGGGAATTAACAGATCCTTCGTTTCGCCACCGCGCGGTTATGGCATTGTTCCCAGACACAGACTCCCCCCTGCCTCGCAAATCAGTGGACATTCTATTCCGATTTGAGCAACTAGCAGGGCAACCGCCATTTTTTCTAATCCAATCAACGGTTGCACCAAAACAAGTGGATAATTTGGATTCCGAAGTTCAGCATCGTACGGTTAGCCTCCGCCGATTTTCTCCGAAATCGGCAGTACGGTTCCGAATCTCGATTAATGGAATTCGACGTCAGACTACCGAACACAACGGCCGAAAACGCATTACAACGTCTCCTGTCCCTTTTGATTCGGACGAAAAAGCTCCTAGCCATATCACACGAATGACCCCTTGGGTTCAGAAGAAGTTAAATGGAGCACTACGTAATGTAGAAATCTTGAACCATCAGCGTGAGGTGATTGGCACCAAACACCGCGGGGGAAAAGCAGCTTCGATGACTATACAAATTGATACGGTTGATGGCTTCGGCATCGTTGAAGATCCGGAACTCCTAAATGAATTGATCCTTCATGGTGTTGGCCGAGCAAAAGCTTATGGCTGCGGTTTACTTTCTGTTAGTGAGATTTAATGAACCCCCATGAGGAACTATGGGCAAAGCAAAAAGGCTTGGCAAAACCATACCCGTTACTTGCCCATTTACTTGATTCGGCCGCAGTAGCAGGGGCATTGTGGGATCACTGGCTACGCCAAGACTTACGCCAAATGTTTATTGAAGAACTCGGATCAAACGCACGTGAAATCATTCAATTTGTCGTAGGATCGCATGATATTGGAAAAGCGACCCCGCTATTTCAATATCAAAAAGCGCAAAAAGGTGAAGTATGGGACAGCATTCGCTATGCTATCGATCGAACAGGACGCTATCAAAAACCACTACCGAGTTCATATCTTGTAAAGAAAACTTCAGGTGGACCAAACCGTCATGAACAGTGGTCCTCTTTCGCTTCTAAAAACGAATATCTAAAACCCAGTGCTGCAGCAAAAGAAAACTGGATAGGCCTTGCGATTGGTGGACATCATGGACGTTTCGAGCCTGTAGGCTATGGACGTCACCAAAGAAAAGCAGCGGAAGATCTTGCTAAAAGTGGCTGGTCAGCTGCCCAACAGGATCTCCTTAGGGCATTAGAGAAAGCGAGTGGCATCACCCGAGCTTCGTTGCCTTCGGAACTGTCTCCAGAATTGACTCTCGTGCTTTCAGGATTAACAATCTTGGCAGACAGAATTTCATCAACTGAATCATTTGTTATCACCGGTGCCAGAATGATCGACGACGGGACCCTTCATCTAGCGACTCCCATAGATTGGCTCAAGACCAGAAAGCTGGACTCCGAAAAACACGTAGCAAAAACTGTAGGAATCTATCATGGTTGGAACAACCACGAGTCAGCAATTCACAGCATTCTCAAGGGATACGATCCACGCCCCCTGCAGACTATAGCTCTCCAAAATCAAGTTGGCTTACTCAATTTAATGGCTCCAACCGGCAACGGAAAAACAGAAGCTGCAATTCTCCGACATTCGTTGAAGGAAAATGACAGACTTATTTTCCTTTTACCAACTCAAGCTACATCTAATGCGATCATGCGCCGCGTACAAGGTATCTACTCTGATACCCCCAATGCGGCAGCACTGGCTCACTCCTTAGCTTCTGTTGAAGATTTCTATCAAACACCGCTCTCGGTTTTTGATGATCACTACGATCCTTCGAAAGAACAATTCGAAAGCAGTATGTCTGGTGGACTATATCCATCTTCATTCGTATGCTCCGGCGCCGCCCGACTACTCGCGCCAATTTGTATCGGAACAGTTGACCAAGCCTTAGCTACTGCTCTTCCCGGAAAATGGATTCATCTACGGATTCTTGCCTTAGCGAATGCACATATCGTGATCGATGAAGTGCATACTCTCGACCATTATCAAACTGCCCTGCTTGAAAATATCCTACCCATTCTCGCGAAGCTCAAAACCAAAATAACTTTCTTAACTGCTACTATGCCAAGTTGGCAGCGAACTAAACTTCTTACTGCTTATGGTGGAGAAGACCTGCAGATTCCTCCTACTGTATTTCCCGCTGCGGAGACGGTGCTTCCAGGTCAATTTAATCGAACACTAATCGATTCCGATAGCACGACCATCGATTTCACCATGGAAGAGACTTCATACGATCATCTTGTCGAGTCACATGTGAAATGGCATCAGACTACTCGGCTAAATGCTCCACATGCTCGCATTGGTCTGATATGCAACACTGTGAAACGTGCACAAGAAATAGCTGCTGCATTAGAAAAAACCAATGATCGTATTGTGCTCTTGCACTCCCGAATGACGACTGAGCACCGACGTCGCTCAGCAGAGTTACTTGAATCGTTACTGGGACCCAATGGTAACAGAAAAACTATTACTGTTGTAGGCACCCAAGCTATCGAAGCCTCTCTCGATATCGATCTCGACATCCTCAGAACAGAGCTGTGCCCTGCCCCATCGCTCGTTCAGCGCGCAGGACGCGTTTGGCGACGCAATGACCCATATCGTTCATCAAGAATCACAGCTGACCATAAACCTATTTCCGTAGTATTCATTGCAGAAGCTAAAGATTGGCAAGTACTACCGTATTTACGCGCTGAAACTTCCAGAACTCAACGTTGGCTTGAAAAACACAACCAAATGTTTCTACCGCAAATGGCTCAGGAGTTCATCGATGCAGCAACGGTTGATTTGGATACTGCGACCTCAGAGATGGACCTTGATGCCTTAGCACTGATGGGTATCCATTTAATGAAGGCTGACGGGGCAAAAGCTCGCATACAAGATGTACTGAACTCCGATTCAAAAGTAAGCGACTTCGCACTTTTGACCTCAAAAAATGAGATCGATGAAGCTCAAACTCGATTGATCGAAGAAGGAACGCATCTTCGCATTATTCTCGGCGACGAGAACGAGAGCATACCAGGTGGGTGGAAACATGGTCTTAGTTCTCTTCTCAAATTAAAAGCATCAGATAGAGAAAGTCTACGTACCGCATTGCTTGCTTCGATTCCTCTTCTTGTATCCGAGAAACAAAAGCAGTTGCTATACCAGCACAATCTAGTACCGCTATCTTCATCAAAAACCGTGCTAGCAGGTTTCTACTTCCTGCCTAAGGCGCAAAATTTCTATAGCAAAAATCTCGGTTTTATCTGGCCTGAGGAGAAAGATTAATATGCCCTATTCCCATGACGCAATTGCGTTCAGTACAATTCCCGCAAGCCATCAAATCAGGCTTGAAGATCGTCTTTCTTTCCTATATTTGGAATATTGTCTGATTCGTCAAGACCGTACTGGTGTAATCGCAATCCAAAATGGTCACAATGAAAGCTCCGACGAAGAAGAAAAATTAGAACCTCAAATACTTCGAATTCAGTTACCGGTAGCGAGTTTGGCAGTTCTTTGTTTAGGACCAGGGACTTCAATTTCTAATGCAGCAATGACTTCCTGCACTAGGTCAGGCTGTACCGTCATTTTTACCGGAGGAGGCGGAGTCAATGCTTATTCACATGCAACTCCGCTAACGTCGACAGCGAAGTGGGCGATAGCGCAAGCTTGTTTGGTTTCAAACACCGAGTATCAGAAAAAAGCAGCGCTTGCCTTTTATAAAAGACAATTCGGAGGAAACGCAATAACCGGTGGGTCGATCTCTGTAATGCGTGGGTTAGAAGGACGCATCATGCGCAACACTTATAGAGAAAATGCAAAGAAGGCAGGCATCCGAGGTTTTAAGCGCGATACAAAAGCTGCTGACCCAGTTAATGTCGGCCTTAATATCTCAAACTCAATCCTCTACGGTGCTGCAGCAACCGTTTGTACTGCCATCGGTGTAAATCCTGCATTAGGAATAATTCACCGCGGTGATACAAGATCGCTCCTGTTTGATCTTGCAGATCTTTACAAAGCTTCTATTGTCATCCCCTTAGTGTTTTCCCACGCAAAAGACGAAGATCCTGTTACTAACATCCGTCGGCATCTCCGCCGTGAGATCCATTCAAGAAAAATAATGGCAGGTATGCTCGAAGCACTAATGGAGGTGCTGACACCGTATCTTCCAAATCGTAATGACGATCGGCTAATCGGCGACAGTGACGAAGTCAAAGGGCACATACAGTATGGCAAGGAGATTAACTAGATGTTCGCTGTACTTTACCTTCAGGCAGCACCTGATCATCTCCTTGGTTACGTCACCCGTTTCCTTACTGAAGCGGATACAAGCATCTATGTTGGAAATGTTTCCAAAAACGTAGCTTCAAACTTATGGATTCGTGTAACAGAAGCTATTAAAGATGCTCATGCCACAATGATTGTGAGCGATAATTCTCGTGAGCAAGGTTTCTCAATAATGACGACAGGTGATAGCACACTACAAGTTCTTGATGCAGATGGGTTATCCGTCCTGGCTTCACGCCCTGGACGAGCCGCTGTAAAATTACATGGCCTACAGTAAAACTGCAGTACAGTTAGTGTCTTCTCCGCACACGCGGAGGTATTTCCGGACGGTACGCAAATACTTACTGCCTTAATGAGTCTTCTCCGCACACGCGGAGGTATTTCCCGCCCTATCGTATGCGCGCTTCGCGGCCATGTGTCTTCTCCGCACACGCGGAGGTATTTCCGAAACCGAAACCCGACTTGAAAGAGGCGAAGAGTCTTCTCCGCACACGCGGAGGTATTTCCATCCGCTCATCTAGGGTTACGCGGGTGGGCAGGTCTTCTCCGCACACGCGGAGGTATTTCCGGCAGGCAATCCAAATATTCGTGTGATGCGTGTGTCTGATGGCTCGCTCATGGACTCCGAGTCTCAGAAGATTCTCTCCGATATTGCGACAGAAACAGGATTCCAGGTGTGGGTTGAGCTGGTTGATGAAACCGGTGAACATGGCATTGTGATTGAAGATGGGCAAGTGCGGGAACTTATAGAAGAAGCAGTGTAAGTGCTGCGTGGTGGGGCGCGCATACCTTCAACGCGCACTAGATCAAAGGACAAAGAAAATGGCACAAGGCGAAGTCAACGTCACCATTGTTGGTAATCTCGTTGCAGACCCAGAACTTCGCTTCACCCCTAATGGTGTAGCAGTAACCAGCTTCCGTGTTGCTTCTACCTCCAAGAAGTACGACTCCCGGTCGAACCAGTGGGTAGATGGTGACGCGGTTTTCTTGCAGTGCAACATTTGGCACCAAGCTGCCGAAAACGTTGCAGAATCCCTCACCAAGGGCATGCGCGTGATCGTCACCGGGCGTTTGCGTCAACGCTCATATGAAACCCGTGAGGGTGAAAAGTGCACTGTGATGGAGCTAGAAGCCGATGAGGTTGGTCCATCGTTGCGTTACGCATCTGCGAGTGTCATGCGGAATGAGCGTAATTCCGGCGGGAATGGGGTTGGTTCCCAGCCGTCGACCGGCGGTTTTGGTGGACAGGTGTCACAACCTCAGTCTGGTGGTCAGTCTCAGGGTAGTGACGGGTGGAATAATCCAGCGCCTCTTGGTGATGATAACCCGCCGTGGTGATCGGGTTATGATTCCGCTATGAGAAAAGATGATTTGAAAGAGGCTGCACTTGTTGCGATGCGGGAGTATTACGTTGCTCGTGATGTTCTCGCGGAGAAGCGGAGTATCGCAAAAAAGGCGCTGAAAACTGCGAAACTTTGTGGTGTTACGAACCGTGAACTAGCGGAAGAGCTGCCCACCTCAGAGAGTGCTTTATCAAGGTTTTCCGCAGGTTAACAACAGAGTTTAACACTACTGCAAACATTGGGTAGTGTCTTTTTTGCCAGCAGGTGTTGCAAAAAACTTGGCAATTGTTAGAGGATAAAAAAACATGGTTGTGAACCAACCTAAACGTGCTGTTTGATAACTCAAAAGAGAGCCCAACCCCACAGAGAACGGTAGTGGGGACGTGTCCCAGCGGAACTACTTACTAATGCGAGCGTGTGTCACAGATCGCCTTGACCATTAGTGCCGACAGACCGAAACCACCCCACCGCACCACAGCCTAGGGGTGAGGAAACACCACATAAGAGGGCACGAAAAACACACGCCATGAACCAGCAACTCCCTAGGCGCAAGCCCTAGGGATGGCACAACCCGCACCCAAAACAGAAGAAAACAATGAGAACAATAACACGCATCGTCTTCTCCGCACACGCAGAGGTATTTCCACCGTCCTCAGCCTCGTAGGACCACAAGGTATTGTCTTCTCCGCACACGTGGAGGTATTTCAGCTGCTTTGGACGGGTTGCGGCTTCTAGCTCGTCAGGATTTCGCGCAGTGGTGGAAAACTACGGGGGATCTGAACAGATTGCGTGATCACTTTTATGAGATTCAGCGATTGTATGGTGAGCAAGCTGCTGCTGCCGCAGTTGATTATTTAGTCCTGAATAGATCTCTTGATGATGATTTTGCCGGTTTGCCTTTCCCTGAGACTGCCGATCCTGTCAAGTACGAGCAGGCGTCCGCTTCGTTCAGTTGGGTGATGCAGACAGTTGCATCACATCAATCTGAGATTGATCGGGTAGCCGCTAAGCAGCGTCTTTTCGGTGTTCTGGATCGCTTGGTGACGTTGCCTGCCCGTGACACAGTGGTACTGAATGTCCAGAGGGATCATACAGCGTATGCGCGTGTTCCAGAACCTGGCGCATGCGCTTTTTGTTTGATGCTTGCATCACGTGGTGCGGTGTATAAAAAGTCCACTGTTGGGATGGTAAATAAGTACCACGATCATTGCCGTTGTCTTGGTATAGAGGTGAAACGTGATGGTTCTGATTTACCTAGAATCAACCGGGACTTAGAACGTGTGTGGTCTAATCTGAGCCATGATCTTGGTCTGCCCCTAACGTTGCGGATCTTGATCGGCATATACGCGAACTCAAAGCGGCTAAGCAGTGGCCTGAGGTTCAACGGGTAAAGGTTCCTTCGTATCAAGGCGATGGGATGCCTAAGGCATTCCCTGGGGAACCGTTACCTAAGGAGCTTAACCGGTTGGTTGGGCATGTTCTTTATGGATGGCGGGATCGTCCTCGTCGCGGTGAAGTGGATTATCCGCACACGGAGAATATTCGTATGGGGCATACGTGGGATAGCAAGCGTGATGTATCTAAGTTTGATAAGTCGTGGTCTGATCAAAATATTGTTGACGCTATCGTTGCCACATTGGAGAACCCAGATTACGCACTCTCAGGTAAAGTTAAACGAGTTGTGTGGAAAGACATCCATGGGACAACTGTGAGAGTGAGCTACAACGTTTGCCTGATGGTAGGGGTTATATCGGACAGGGCATACAGCGATACTCCAGATAGGAAGGCGAAGAGAATTGTTGAGTAGCAAGGAAGTTTATGCTCGACTCGATGCCATTCTTCCGTCTAGCGTTGATCGTGAAGACGCAGAATCTAACCTTAATGCGGGAGAAATTGAATACGCTATCACCGCGCTGTTAGACGATGCATATACGTCTGTTGGGCTGTCTGATGCAGTGGTTAGTCTGATCAGAGAAAATTATGATGATGGCCCTGTCATCGACATGCTTGACGCATTGCTGTATTTCCAAAAATTAAACAGTGGAGGTGATGCCGTGAGAATGCAGCGCTAATAATCAGCCTATGCAGTTTCACCCTTGAAGTCATCAGATTCCGAAAGGAATACCCAAGACACAAAGGGAAACACCACAAATTGCCCATAGGGCTGGCTAATCCAAGTAGCCAGCCCTATGGTCCTCCACAAAACCATACAAAAAGGAGACACGCAATGACATCTCGAATTATCGGATCACTCGCAGCCCTTACCGTTGCCATCGGCTGCACAATAGTTGCACCAGCAATATGGCCAATCACCACCGCACTCGCAACCATATCCATCATCAACATCCGAACCCAACTCCGAAAAGAAAAAGAATGAACCCCACCATCACCGACAAAGACAGCGGACGAGAACTATGGCAAGTAGAAGACTGCGCCAAACACTGCGGAATCAACACCAACACGTGGCACACCGACACGTCCACGGGACGCGCCCCTATTCCTTCTCATTTTTGACCCACAATTGCCAACGTTGACTACCCGTTCTCCTCATTCTTCTTACGTCTTTGAACAAGGAATCCGGCAATTGCGAGTGCAATTCCTAGGGCTGCGATGCCCAGCACGTTAGCACCCGTGTTTCCCAATCGATCGGTAACTTCCTTACGGAACTTCTCTGGCAGGTCAGGTTTGCCAGGGGTTTTAGGGGTACCTGGAACAGGTGAACTCGGCGTTAGCGTGACTGAAGACTCTACCGGCGGGAAGACTGGCACGGTTGGGGGAAGATCGTCAGTGTCTTTGGTAAACACCTGCACGTCACAAGACCACGATGCAACGTTTCCATCCGCTGTCCGCATTCCAGCAGGCACCGTGATTAAGAAGTCCAGGGTCCTCCGATATTCTGCAGGTCGTTTCGCTGGCGGAGTCTCAGAAACAAGGTAGACGCCCATGGGGAGACCAGTTACGACCGCGCGACCATCACGCCCCGACACGGCCTTCCAAACTTCGTCGCTGAGCCTGCTTCGCGCTTCTTGGATCGTAAGCGCTTTGGCCGCATCCCATCCAGCTTGTTTGGTGAGATCGATGCCTTCTATCCGTCGAAGGGTAAATGTTGCTCCGTCGATAGTTCCCGCGGGCAAGTCTGCCTTATCGACGCCCTCAAACGCTGCGGGAGGACGTTTAATTAGCGTTAGGGAACCGGTATCACAACGAATATCGGAAATGTTGAGCCCATCCGTAGCGCCGGTGATTGTGCGGCCATCTGCATTGGCAATGGGCCCGGACGCTAGCAACAAAGCAACGGCCGCTGTCGTAGCCGCTGGAATGCGGAACAGGTGACTCTTCTTCATAGTAGGGCGTCCTTTCAGGAATGGGCGACTGCTTGGGTGTTTGCATGTGTTGGGGAAAATTGGTTTCTGCATATTACTGGGACTCCTCGGCCGCTGAAGTGCTTAGCGACGCCTCAGTATCACTAGGTTCAACAGATTTAGCAGCGTCTGCTCCAGCTGTTTTCTTCGCGAATTTCCTAGCTCGCAAAATACGGATAATGAGCCACCCGGTTAGGAGAAGGATGACCACCAACACACCGATAGCTAGCTTCATCCACCACTGCCAGACAATTCCGTCACCGGCAAATGCACGGTCCGCCTCACCGGGTTCCATAGGGACACGTTCGGCAGTAACCAAAAGCCTATGGGTATTGATTCCATAGGGTGTACAGGTCACGAGGGTAATTAAGTCTCGGTCTGGGATTGGCTGGATACGGTCAATCTCTGCTGGACGGATGATTTCAGTGTCGCGTACTTGGTATTTCAGGGTCTCACCAATATTGCGTACATAAATGGCGTCACCCTTTTTGACCTTTTCTAAATTGTCAAAGAAGGTCGATTTTTGGATACCTGAATGCGCTGTTAGAACCGAACGCGTCCCCAGTCCACCAACGGGTAGCGCAGTACCGTAAAGGTGCCCAACACCTTTGAGGAGTGTGGCGTCGCTTGTCCCGTGGTAGACGGGAAGGTTCACGGAAATAGCCGGGATAGAGATCTGAGCCATCGCCGGGTATTCCCCTAAGAGTTTCTCGTATGCCTGATAGGCAGGATCCTTAGTGCTATCTCCACCGGTCCACGGATCCTGCAAGGGTCCATTTTCTAGCGAATCGTTGTAGGCATGGGCAGCATCAAGAGCAGCAGCAACTACGGCAGGGTCAGCTTGGGCAGCGTCTGCACCAAACTGTCGGGCGAGTTTAGACTGTTCATAATTGTTAAGTTGAGTGGACACGACTGGATAGAACAGAATCACCAGCCCTAACAGTCCGCACAAAAGCATGACTATCGCAGCAATTGTAGTCTGCGCTTTCTTTTTCGCTGAGCTCTCACCAGTACCCGCATTAGAACTGGTACCGGTGGAGTGTTTAGCGTCGGTACTGACCACGTTGGGTTCCTTCCCCGCCGTTTCAGAGTTCATCGCCATCAGCTTCGCCTTCGATGTCTTCTTCCTTCTTCTTTGGAGGAATCATGTAACCCGAACGCCAGAAGAACAAGGCGATAAAGCTAAATCCCACTGCGAAAATGACCGCCCACCAAGGGAAGCCGATTTGGGAAGCTTGGCGTGCTGCATCGATATCGGATTGCGGGGTGGAAGTAATGCGCTCAGCTGTCACCAGAATGCGATGTGTATTGATGCCCAACGGAGTACAAGTAACGAGTGTGACAAGGTCACGATCGTCTTGAGTTTGAAGGAACCTGGTGTCCTCTGGGCTGACCACACGAGTTTCACGCACTTCATACGTAAGGACTTCGCCCATCACCTCAATGGTGAATCTATCCCCTACCCCAACCTTGTTGAGATTAGTGAACATGGTGGCCTCAGCTAAGCCACGGTGTGCAGTGATAACGGAATGGGTGCGTGGTCCTCCCACCGGTAACGAGGTACCTTCCAAGTGGCCAGCGCCCTTCTTTAGAGTGTCATCGCTCGTGCCGTGATAGATCGGTAGATCCACCTTGATAGAGGGGATACGTATACGAGCCATGACATCCGTACGGTCAACACGCAACTGGTCTTTATAGGCCATACCGTCGCCGTCTTCTTTGCCCGCTCCGCGGGGGACGTTAGCCCAGGGATCGAGAGCAGCGCCTACGGTCAGGCGGTCGTTATAACGGTGCGCGAGTTCAAGTAATTGTTCCGCGCTAAGAGGGGTTGCATTTTCAATTTTGGAATCATAGAGATCTACCAGTTTGGCCTGTTCGCGGGCGTTAAACCACGCTGCAGTAGATGGATACAACCCCAACATGAGGCCGGCTAGCGCCGTTATACACGCAAACAATGCGAGTCCGGAAAAGACCCAACGACGCTTTGGTTGCGCGTCTGGGTTATCCGGTCCGGTAGAGCGCGGTGACGCGGTGGTAACCATGACAGGTACGTCCGTTTCTCATATAGGGGGATGCCGGGTGGCACAGGCCAAACAGCAAATCTCTGACAAAGAATGTGGGGGTGCGGTGGAAAGCCACCGCACCCTGCCGGCGTTTATGCCCGCCGGCGGGGCATTTGATGCCCTGCATTGGGCGGCGCAACGCGATTATTTAATCACGCGACAAATCAATTACTCGTTGATACGGCGTACAAAGACGAAACCAGCACCAACAGCAACCAGCAGCAACAGACCACCGGCAATCATCAGGAACAGCACACCCTTGCCACCGGTCAGCGGCAGGTCAGGGGTATCGCGCTTGACGTTCTCGACCTTTGCGTCGTAGGTAGTGGTAGCAGTCTGTCCAATCTTTACAGCAACTGGGAAGACCGTCCCATCTTTCGGGGTAACGAAGCCCGTCGGGGCCTCGGTCTCGACGAGGACGTAGCAGCGCTGCGCAGCTGACTTTCCCGGATCATTCTGGTCGTCGGAGACGAACAGGCCCTCGAAGTGGACGTTGCCGTTCTTGTCAGAGGTGACCACGAGATCGTTACCGTTACCAGTGCCGTTTACCTGAACCGGAGCGTTCTTGTCATACTCCGGACCACAAGTTCCGTTTTCTGGGTACGGTTTGGTTGCCGGGTAAATCTTGAACTTCGCGCCCTCCAGACCCGTCTTTCCGTCGCCCTTGTCAACCTTGAGGATCCTCAGATCGCCCCAGAATTGCTTGACCAGCGGGGTGCCGCCCGGAGGGGTCGTGGTCACAGGCGGGGTGTCCGGCGGAGTGGTGACAGGCCAAATCGGAGGGGTACTCGGCGGAGTCGACTGACCCGGGTTAGATTCAGTATCCGAGTAAACGTATGCCTGGTTGAGGATTCGACCAAATTCTTCAGGCTTTCCGTTATCGAGAGACTTCAGCTTACCTTTGAATACCACCTTGAGCTCCTGGCCAGCAGCATTCTTCAGCTTGCCCAGCCCCTGCGACGTCAGCGAAACGATAACGCGCGAGCCGTCACCTGCGACCGTGTAGTCATCGGATTCGAGAGCCTTACCATTCAAGGTTACAGACTCAACGCCCAAGGACTCCTGGTCAAAGCGGGGATCCATCGGGTCGATGACTTGGAAGTACTTGAACACTTTGTCCTCAGCCACCTTCGGAATCACGGCTGTTACCGGGAAGTGCACCTCAGACCCGACGTTAAGACCATACGTGTTCTGCATCTCGACAGTCTTGTTGAGCTTAGTCTTACCGTTCTTCGGGAAGACGTTGACGTCGTACAGCCAGGTGTTGGTGCGCTCACCGAGACGATCGTCGTTAGCGGTGGTGTCCGGGTACGGAAGGGTCACAACGAACGGTGAGGCGCGGTCGATGACGTCGGCCGGGGCGTCGGTCTCATAGACGACGTAGGCTGCGACCGACAGGTCCTTCGTGGTGGCCTTGCCGCCATTAGCGGTGGTGACGGTGTCGACTTCCTTAAGGTTATCGTCTTTGGTCGGGTCAGCCGGGATATTGTACTTGTTGACTGCCTCCCAGCCCTCCTGCTTCAACAGGTCGATGTTCTTGATCTTGTAGATCTTGAACGTCACTCCGTTTAGGCCCTCAGTCGGGGTGCCCTTGTAGTCGCCGGTAGCCGGATCGCCCACGGCGGAAGAGCCGTCCTCCTGGTGCAAGTGCTTGTTGATGATGATACGACCCTGCTTGGTGAAGTCGATATTGCCGTAATTGGCAGCCGCCACATTAGCGGACGGCTCGGTTTGAGCCAGTGCCGGGGCAGCGAAGCCGGCGCCGGACAGAATCAGGGCGGAAGCGCCAACGGCGCAGGCTAGGCGGCGACCAATGGTGGTGCGCTTAACACTCATAGGGTGTTTTCCTTTCAGGATTCTCGCCCCTGGTCAAGAAAGCGAGAAGAGAGTATCAGTTAAGGGGTTTATAAGCCATGAGAGGCTTGGTGAATATGTGCGGTTAGCTGTTGCGACGTCGCATTACATGCGCGCCTCCCATCGCTGCCGATAGAACTCCGAGGAGACCACCGGCGATCAGGAACTTAAATGCTCCCAGGCCGCCGGTCAGTGGCAGCTTTACGCCTTTACCAAGTTCGTTCTTAAACGCTCCGGCCACGACCTCCTCACCGTTCTTAGAAATTGTGAAATAGTGTTCTGTGGCATCGACGACGAAGCCTGCAGGTGCCTTGGACTCAACGAGCTTGTACTCGCCAAACTCCAAGCCGTCGACCTTGAACGCACCACCCGCCGGGTCAATGTCAGGCCCCGTGCATTTCGATGCCGCGTCTGCTTGGCAGTCGGTCACTTGGATGGCCACGGCGCCGTCGATGGGCTTGCGGTCGGCCGTAACTTTGACGATCGTCCATTCGGAGCTGTGCAAAGCCTTGCCGGACTGGTCCAACTTGGTCCACGTCACGACGCCGTCCATGCGCTCGTTCTTGATGGCGTCCAAGTCAACAACGGCGCCCGCCTTGGAATCGTCGACGGTAAAGTCCACGCCGGCGGAGGCGGCATCGGCAAGCACGTAGCCCTCGGGTGCCTTGGTCTCCTCCAAGCGGTACTTGCCCGCCGGCAGAGCATTGATCTTGAACTGACCAGCCACAGGATCCTCGTCGAGGACACCAGCCGCGTTCGGAGTCTTATCGACCACCTTCTTGGCGTTGGCGGTATCTAAGGTGCCGTCTGCCTTATAAGGTGTGATGGTCCACTCGGATCCGCCTAGGAGTTTCGTAGCGTCGGTTGCATCAACCTTCTTCCAAGTGACCCCCGCTTCGATCTTCTTGTTGGTAACAGAACCAAACTCCAAGACCTTAGTGAGGTTGTCGCGAGTCAGAGTGAACTCCTTGCCGTTCTTAGCCTCATCACTAATGAGGTATCCGGCAGGTGCTTTCGTCTCCTTCAGAACATAGGTGCCGAGTGGCAGCTCCACGGTGAACTCGCCCGCCGCAGTATTGGTATCCTTCTCGGCTCTCGCACCGGCAACTAGGTCAGTGACCTTGATTGCGTTTACCTCATCAAGAGCACCAGTGGACGTTTTAGGGACGATGAACCACTCCGAGCCACCAAGCAACGTCGAGGTCGCGGCCGCGTCGACCTTGGACCAGTGGACCTTAGCGGCGTCCTTATCGTTGGTGATCCCGCCGATGCTCAACGGGATGTAGTTGGTGCCGGAAGAAGGAACCGGGAACTTCTTCTCAGTGTTTCCATCGATGGAGTAGCCGGTATCGGTGATCTTGAACGTGTACGTCTTTTCGGTTACGAGGTACCCCTCTGGAGCCTTCGTCTCCTTGAGGGTGTACTCGCCGTTGCCGAGCTCCGCAACGCTGAATTTACCTTTGCCAGGGTCAATGTCATTCACTTCTGGCACACATTCGGATGCAACGCAATCCTTTACAGAAAGCTCCTTGCCGTCTGGTCCAGTGAGCTGCCATTCCGATCCTGCAAGGGCGTTCTTCTCATCTGCAGCATCGACCTTGGACCATTCAATACGAGCCTTGTAGTTCTTGATAGCTCCGCCAGGAACTGCTTCGACGTCCTTCTTGGCTTTATTAACCGTAAACTCATATGCGTTCGCGCCCACGATGCGGTATCCATCAGGCGCCTCCACCTCTTCCAGACGCCACTTTCCATAGGGAAGGTCCTCTACCTTAAATTCACCGGTAGCCTCATTCGTATCGCGAGTCGCATCTTCGGTCTTCGAAGTCTTGTCCTTAATCTCAAACTGGTCACGGCCGTCTACCAATGCCTCGGCAGCAATCTTCTGTCCGGAGGCATCCGTCAAACGCGTCAGTTTCCACGTCGAGTCATGCAGAATCGCACCGGTCGCCGCGTCTGTCTTCTTCCAGGTGACTGTTCCCTGGGGCTTGAGGTTGAGAATCTGTCCCAGGTCAACGACATTCGTGTCGGTGTTCTTCTTGGCCAACTCCTTCCACCGTTGGTCCAGCTCGGCAGGGCTCTCCAGGATAGTCATGCCCTTGACGTCGAAGGAGAACTTAATCGGATCCGACAGCGGCTTATATCCATCGGGAGCTTGATCCTCACGCAGATAGTAGGTGCCATATGGCAAGTCGGTAACCAGGAACTTTGCAGAAGATTTGTTCTTATCAACTTTCAGGCAGCCTGCATCGGTATTGGCGTCGCAGTCTTTAATCTTCTCGTAGCTAATCGGACTGGTAATCACCTGCTTGTTGCTGTCAAGCAGAGACCACACGGAACCACCAAGCTCAATGACGGAGGTGTCCTCTGGGGACTCCTTACCAACCTTGGTCCACGCCAAATCACCCTTAACTGGGGTGTTTTCGTACATGCATTGGAGCTGCCATGCAGAATATGACGGGATCGTGACATCCCATTCACGCTTCGTGGAGGACGTATTGTCCACCGACTTAATATACGTCGAAGGTAAGAATGCCCCCGTGAGTGTGTCTTTACAGGTCAAGTTGGATTTGTAGTAGCTGAGTCGAGTCTTGCCGGTCCCTTCTGAGACGCTGGGGACCTCGCGGAGGCGGAAGACCTCGTCCGGGCTAGCGATCACGGGGCCGGCCACCACTGGCTGTTCGCCAATCACTTCGCCCGTAGTAGAAGTCCACGCCAGCTTTTCGTTCGTGTTGGTGCCTGTGCCGCGCGAAATCTGCAGCTCCACCTGATCAGCCTTGGCAGCACGGCCGGTTGGGAACGTCTTCTTGAGCTCCAGCGTCGAGAAAGTTGCACAGGATGCAAGGTCGCTTTGGCCACCGTAGAGCCACGCCGCATAGCCTCCATCTCTATCCATATAGACTTCATGGGTGCCGTCATTGTTAAAAGTTTCTTGGGCGACCACATTACCCGTGGTCGGATCGACCTTGTAGAAATACGCTGTACTCTGGCGAGCATTTACGGTTCCGTCTTCGATCATGAGGTAGCCATCCACAGTAAACGACACACCGTTAAAATAGGAGGGACCAAGATCATTGGGCTTCACCTGAATGGTTGTCGTCGGCTGCGGAATAATCTGCCGCGTCGTACCCGTTCCCTCAAGCTGGTCAGCCAGCACTGGAATGAGCTGTACGTTGGTCGTGCCACCTTCGTGGAACAGCAAGTACATATTTCCCGATGAGTCAAAGGCAAAGTCACCATTGACTGCGGAAGTGGAATTCTGGACGGGAGTCGATATTGGAACAATACCGACGGTAGTTATCTGTCCACCGAAATATTTATAGAGCACAAACTCTCGCGACCTTTCAGCCACAGCGGGGCTCCAGTAGCGTCCCAGAAATTCGCCTGAATTGCTCCAAAACCCAGCGCTACTGTAATAATAGCGGCGTCCGTCGGTGCCGTTATAGTAGTAATAGCCGAGACTAGAGTCGTAAGAATAGGTCCAGTTCGTCACCGGAGGATTGTTCGTATAAACAGCTTTCTTGGCAGCTTTCACATCCCCAGAAAAGCGGTAGCCACCGAAATAGTATGTGCCATCCGGCGCTACGGCACCAGCAATAAGACCAGACGGAGTTTCCAACCTATAGACATTCGATACGTTTCGCTGCCCATTAACAATGTCCCCGATCTGGACTTGAGTTACAACCCAGCCGTACGTCGAGGAGTTCTCATATCTATAGCGGTTATAGGCGTATACGGTCGAGCCATCCTTAGAGACACCAAGACCGTTCCAATCCCCGCTCGGTGAAGAACCACTGCGGAAGCTGTACGACTGCCGGTTAATTGGGTTCCTCCCCCATGCGCCGTTCTGCTCCTGCAATTGCAGTACCTCGCCCCACTTATGGATAGCGTAATAGTAACCTTCATCGCATTTCAGGTTGCCCGATCCCGTGGTTGTGCCCATCGCAGCGGCGGTGGCGAAGGTACCAGCAATAGATTCCAGCTCCTCCGGCGCGGGCGCCTCCTCTTCCCCCTCCACAGACTCTAAGTCCTGTGGCTTGGGTTCTAGTGGTGGAGAATCCGAGTCAGCAAGCGCTGCATCAAGTCCGACTTCATCTTGGGCCGCAGCACTAACGCTGCCTGCCATCAAAGATACGGCCACGATGGGTACGGCAGCTAGGGCGGCAAGACGTTGCAAGAAGTCATTCCGCCCCTTTAAGGACCATGCAGTCATGATGAAAACACCTTCTAGGGGGGGAGATACTAGAGGAAAGCCATGTTATAAAAATTCCTCAAGAAACCTAACCATGCTACCATTTCAAACACGGACTTTGTTAAGGTTTATCCCATTTTGAAGTGCCCTAGGTTTTGTTCCGTTTGAGTAGATGGGAAAATCTTCGAACATGCCAAGGAAAATTTGACCAGGATGCGAAGAACCGAGTCGTCCGCTTGGTAGAAGATCGCATCCTAGCGGAGAACATGTCCATGCAGGCAGCCTCCAAGATCGTGGCACCAAAGCTGGGTGTTTCGTGGCACACAGCGAGGCAATAAACACAAGCCCGCTCGACGTGAGGGGACACGTTACTGAACGGTTGCCTGAGGACCTTGTGGCAGAAAAACGCACGGTTGCGTCGAGAAAATCACCAGCTGCGGGGCACCAATGAGTTGTTAAAGGCCGCTTCGGCTTTTTCACCTCACGACCAGGCCCGAAACGTTAAGAAATGATTCCGATTCATCGATGAGTATTGGAATCGTTTCTCTGCTTTGTTCATCTGTCAGACGTTAAACACGCATCGTGAAGGCGGTTTTCTTAGCTTGCGTGGGTGCCGCCAATCCAAGGCGCGCGGGCTTAAGTGCCCGTAGTCTTCGCGACGCTGCTCTTGTGGAGCATATTCGTGACGTTCATTTCCGAAAACTACGGTGTCTACGGGGTGTGGAAGATGTGGCGCGTGCTGCAACGCCAGGGCATTGACATTGGACGTGAGCATAAAGCCCGGCTGATGCGCAGTGCTGGGCTGTCCGGCAAAGGGCAAAGGTGGGGCACCTGTCACAACGCGTAAATCTAAGGGCCTGGATCTTCGCCCTGACTTGGTCAATTGTGAATTTAGGGCTCCTGGCCCCCAATCGGCTGTGGGTGGCTGATATTACTTATGTGCGCACTAGGAAAGGCTTCGTGTACACCGCGTTCGTGACCGATGTATTCTCCCGGAGGATCATCGAGCGGGTGTTGTCTGATTCGATGAGCACTTCAAGCCTTGCCGCTGCAGGCGTTGAACCAGGCGATCGTGTGTGCCAAGGAAACGACGGGTTTGATTCACCATTGAGACCACGGCTGACAATATGTGAGCATTGTCTACAATGAGCGCTTGGCTGAGCACGGTATCGTAGCGTCTACTGGGATGGTGGGTGATTCCTATGACAATGCTTTGGCTGAGAACGTCAACGGCTCCTCACAAGAATGAACTGATTCATAGGCGCTCCTAGGCCGATGTGGTTGATGTCGAGGTTGCCACGTTCGAGTGGGTGAATTGGTGGAACGAGTCACGGCTCCACCAGAGTCTGGACTATCGCACGCCGGCTGAAGTCGAAGCCGAGTTTTGGGAACATCACCCCGGTCGAGAATGAACTGCTCCCCATTAGTTGGACTGAGAAATCAGTTACCTACTAGTGAGGAGCAGTTGTATGCGTGCACGTAGTTCGTTGTCGGCGGGACAGCGGGAAGAATTAGTGGCTCTTTTCGAGCAGGGTTATAGTTATTGGGCTGCAGCTCATCATGTTGGTGTTGGTGTTTACCCAGTCCGTGCTTTGTTTCGTCGGTTCTTGCTCCATGGCAAGCTATGTCTTGTGGAAAAGCCTTCAAAGCAGCAGTACTCTTTCGAAATCAAAAAGGAAGTCGTCCAACGCCATCTAGCTGGCGAGTCGAAGATGGATCTGGCCCGTGAGTTTGGTCTGTCGTCGGATCAAATGGTCGGATATTGGTCGCGAAAATGGCGCAAAGGCGGTGATGACGCGTTAAAGCTGAAACCGAAGGGCAGGCCTAAAGGTTCAGCTAAGCCGAAGGTGCTTACTGAAGAAGATAAGCTGCGTCGCGAAAACGAACGGTTGCGGGCTGAAAATGCTTATTTAAAAAAATTGCGGGACTTGAGGAACCAGGGACACGCCTGAAAGCCCAGGCAATCGTCATCCTCAAGTCACAACACCGCTTGGCAGATCTCCTCGCGGCGGCAGATATGCCGCGGGCGAGATTCTTCTACCATCAAACCCGACTCGATAAGCCGGATAAACATGCTGCGGTAAAGCACGCAATCCTAGAAAGTTTCGAAGCCAACAAGCATCGCTACGGCTACCGGCGAGTGGTGCTGGACTTGCGCAACAAGGGCTGGGTGGTCAACCACAAACTCGTCTACAAGCTCATGCACCAGATGGGTCTTCGGGCTAAAATCCGTCAGCGCAGGCCCTATAATTCCTACACAGGAACTATCAATCGCATTGCTGACAATAAGCTTGCCCGTAAATTCACTCCAGACAAGCCCAACACCGTCTTTGTCAGCGACGTTACCGAATTGAGGGTTGCAGGCCGCAAAGTGTATTTATCACCGGTAATGGATCTCTTCGACCGCTGTATTGTCGCTCACTCCGTGGCTACATCACCGTCGATAGCATTTACCGCCGATTCCCTAACAAAGGCGATTGCAGCCTGTGCGCCGAAGCCTGGATGGATGATGCACACCGATCAAGGCTTCCAGTACCAGCATTCAACCTGGCGTAATCTAATCCACGACAACGGCGGTGTTCAGTCAATGTCGCGTAAAGCTAATTGTTACGACAACGCAGTAATGGAGAACTTCTTCGGACACTTAAAAACCGAGATGTACCACGGAGAAGTTTTTGGAACCGTCGAGGAATTCACCCAAGCTGTCGAAGACTACATCCAGTGGTATAACACCGAACGCATCCAACAACGACTCAAGGGCCTGACCCCGATGCACTATCGGAATCAGGCCCTTGAACCCCTAACCACCTAGAATTAAACCAGTCCAACTTTTGGGGGCTAGTTCAGAAATAATGGAAATCAAGGCAAATACCTAGGAACAAAACCCAGGGCACTTCAATGGAAGAAGCTTCTTGGCAGAGGTCTTAAACCATCAGGTAGTATCACTGTCTTCTTTGCTAGGATGCCGCGATTATTTCTCACGGCATTTTTCGAAGTCCTTCCCATTACGTTCTAAGTGGTTCCACCGGAGAGGAGAAAGCCATCGAGAAGAAATAAGCCCAATTCTTCTGAACAGACTTCCTCAGTTGCTTCGGCATCAGCGCTAACCGCATGGACTTGTTTGAGCAAGACGCACGCCGCGGCTCATCCGGCAGCCACGGCTGACTGCTCGCCAGCGACTTCGAGAACTTCCGCTTGGTACGCTTGGGGGAACCAGACCAACGCTTCGATCTGTCCTTTACCCTGTCGGAGTCACCGATTACCTAGACCAGCTGCGATTTTTGTCCGGCTATCAGGGGATCACCCGCAAGGCAGAAGAAGCAGCGATGCTCCAACGAACCCGGAGGATGAGGACGAGGACGTCCCAGCGCACCGCGATCTTCCTGCCCGGCCACTGTTTCTCCTGTTCGGCGATGATGCGGGCTGGTGGAAGCAGAATCTGTTCTATCTCTTCGTCCTAGACGGCATAAAAAGCGAGAACCTGGGTAGCCAGTTGGATGCGCTGTTTGCTGTGCTCAATACCCCGGAGAGTAAGCGGCGCATGGACGTAGCCCGCCACCGTTTAGCCGAAGCTAACAGCCAGATTGTCGCGCTGCTCGTCCCTAACGGTAGGTCGGACGAGAACAGTGCAGCTGACGTCTTTGCCTACAGCGCGGAAAAGCAATTGGAGCACGCCTTTCAGAGAACTAGTCAGAGCGGTGACCATGGATACAAAGTAGGACAAGAATTATGGCGGGATAATGTCTCAAGGCATGAGGGTGGCTTGGAGATGTAAAAGGATTTTTACAACGCAAAAGCCGTTAGCGCATTTAGTGTTAAGAGCTCAGGGGTAAATAATCGCGAACTCAGCTCCACTGCTCACACCCGCGAGCCCAGAAGCGGCTGAAATCCTGAACTCGGGTACCATCTTCAAAAAGGTATCAATGTTCATATGTATCAATCCCCTTTCTTGGTGAGTATTCTGTTCCAAATCCATTTCCGTAGGATTACTCAGGGCCAGTTTTTCCTCGAATGATTTTCTGTACGTGTAGGAAACGGAACGCCACGAATGGCAAGACGGTTATGAATCAACGTGATTAAATAATACTTATCCTTGACGAACCTCGTCCCTTCCGGTAATCCTCACTTTCGGATAGGTCTAACCAAAATAGAAAGAGGCTCAATGGAGGCATGGATACCTCCCGTAACCGGAGTGCTCACACTAGTTTGTGCACTTCTATTCGGAATCATCGCTATCAAGAGCAAGCATCGCACTTTACCTCGGAATTCTATAGTGGGAATCCGGTTGGTGAGCACCCTAAAATCTGACGAGGCTTGGAAAGCGTCTCATCAAAAAACTTGGGGAATACCTGCGTTGTCTTCCGCTATTTTTCTAATCGGTGGACTACTTCTAATATTTCCCGAGAAAACAACCGAGGCTCGGTATGTATTGGTTACCGCAGTCACCTATGGATGTCTGATTCCCCTCCTAGCAATTCAGGGAACTCTTGCAAATCGCGCAGCAAATCAACAGCTTCAACACTCTAATAACTAAGAGATCTGGATGCATAGCACAATCATCAAACCCGACCCCACAAAACAAACCCGACGAGCTACATAGTTCGTCGGGTTTGCTGTTATTTCAGGTGGAGGCAGTTAGTTTTCCCAGTTGTAGGTGCGTTCGACTGCTTTGTTCCATTCGGCAAGGAGCTCGTCGATCTTGTCGGCGTCCATCTTGGCGTGCCAGGTTTTGTCTACTTCGTTCATGCTGCGGAGTACGTCGAGGCTGTCCCAGTAGCCTACGCCGAGGCCTGCTGCGTAGGCTACGCCGGTGGCTGTGGTTTCGATGTTCTTGGGGCGGGTGACGTCGGATCGTAGGACGTCGGCTTGGAATTGCATGAGCAGTTCGTTCATGACCATGCCGCCGTCGACACGCATTTCGGTGAGTTCTACTCCGGAATCCGCGACCATGGCATCGATCACTTCGCGTACTTGGTAGGCGGTGGCCTCGAGCACTGCGCGGGCGAGGTGCTTGCGGTTGGCAAAGCGGGTCAGGCCCACGATGACCCCGCGGGCGTCGGGGCGCCAGCGTGGTGCGAATAGTCCGGAGAATGCGGGGACGATGTAGACGCCACCGTTGTCGGGTACTTCGCGGGCGAGGTTTTCGATGGCGGGCGAGTTCGGGATGATTTGGAGGTTGTCGCGTAGCCATTGGACGAGCGAGCCCCCCATGGCGACGGATCCTTCGAGGGCATAGACCGGTTTTTCGCCTTCGAGTTGGAAACAGACGGTGGTGAGCAAACCGTTTTCGGAATGCTTCGGGGTTTTTCCTGTGTTCTCCAGAAGAAACAGCCCCGTGCCGTATGTACATTTGGCGTCACCTGGGCGGAAGCATGCCTGTCCGAACATTGCGGCTTGCTGGTCACCGAGGATGGCGCGGATCGGAACACCAGCTAGTGATCCACGAGCACGTACTTGGCCGAAGTTACCAACTGAAGGACGAATCTCTGGCAACACTTGCATTGGAATATCCAACGCGGCACATAGTTCCTCATCCCATTGCAGGGATTCGAGATCCATGAGCAGGGTGCGGGAGGCATTGGTTACGTCGGTGGCGTGAACGGCGGGCTGGCCGTTGTCGCCCTCGGCACCGCCGGTCAGGTTCCACAGCAACCACGTATCAATGGTTCCGAAGAGCAAATCGCCGTTCTCTGCTAGTTCGCGGGCACCCTCGACGTTGTCCAATATCCACTTGAGTCGCGGGCCTGCGGGGTATGAGTTGATGAGCAAACCGGTACGTTTTTGCCACCGGGCAGGGTCGCCTTGGGCTAACTCAGAGCAGATGGAGTTAGTGCGGGTGTCCTGCCACACAATGGCGTTATATATGGGCTCACCAGTAGTTTTGTTCCAGACCACCGTGGTTTCACGCTGGTTTGTTATGCCTACGGCCACGATGTCTTCACGGGAGACGTCGCTTTCGGCGAGTGCTGTCCCAACGGCTTGGCGCGTGTTGGCCCAGATTTCCATTGGGTTGTGCTCTACCCAGCCTTTTTGGGGGAAGATTTGTTCGTGTTCGTACTGGCCAACGCCTACTTGTTGGCCGTTGTGGTCGAAAATGATGCAGCGTGTCGACGTCGTTCCTTGGTCAATCGCAGCAACATACTGTGGTTGATTCATTGGTGTGGTTCCCTTTCACTACAGCACTACAGTGGCCAGCACTCCGCAGAAGACTGCGGCGAGCATGGGGCCGACGATCGGAACCCAGGCATAGCCCCAGTTCGCGGATCCTTTGTCTTTAATGGGCAGCACGAAGGCGTACATCAGGCGGGGGCCGAGGTCACGCACAGGGTTGATGGCGTAGCCGGTCGGTGTGCCTAGCGACAAGCCTATGGCAACGATCACAAAGGCGACTGCGAAATAGGTCATGGGGCCTAGGTCGCCACCGGTGGGGCCGAAGAAAATGAACAGCAGCAGTACGCAGGTACCGATGAACTCGGTGACCATGTTCCACCCGTTCTGATTGTGGGCGGGGCCGGTGAAGAAGATACCACCGGTGGTGCGGTTAGCTCCCGTAACGTTTCCGTTTTCGTCGGTGTTGTTGGCGTCGAAAAGCTGCTTGAATGTCAGCCAGCACAGGATCGCACCAAACATGGCTCCGAGGAACTGCCCGAGAACATAGCCGCCTACCAGGTTCCATGGTGTACTGCCTTTGATCGCCAGCGCGATGGTGACCGCTGGGTTGAGGTGGCCGCCGCTGGGGCTTGCCACTGAGGCCCCGACAAATACCGCCATGCCCCAGCCGAAAGCGATAAGCACCCAGCCAGTGCCTTTGCCTGCGGAGGTGCGCAGGCTGTTGACGGCGCAAACGCCGTTACCGAGGAGAAGCAGGAGGGCTGTGCCCAAAAACTCCCAGCCGAATGCTTGTAGGGCGGTCATTAGTTATCACCTGACACATCCACATAGCTGCGCACCGCGGAGCCTGCCACGATGTGCTCGTTGGCGGCTTTGTCAGTGAGCTCCTTCTCGGCGGCGATTTCGGCGGACACGCGGTCGGTGAACGCGGTGACCTCGGCGGCGGTGCGCTCGGCGTCCCAGCCAAGGTAGTCGGCAACGAGCTCGGCGATGGCGGGAGCTGCGGCAACGCCACGGTCGGCGTATTCGATGCCGGCACGTAGGCGACGTTCCACGATGTCCTCGACGTGCAGGGCACCCTCGTGGGTGACGGCATAGACGGCCTCTGCTTTGATGTAGCCCGGCGCGCCTGGGATGGGTTCGAGCAGCTCAGGTTTATCGACGCTCGGTTCTAGGACCTCATGGACGAGGGAGCCATAGCGGCCGAGCAGGTGCTCGACGACGTCCTCTGTGGTGCCGAAGGTGCGGGCGATGCGCGGTGCTTGGTTTTGTAGGGCGTGGTAGCCGTCGGCACCGAGGATCGGGGTGCGTTCCGATTCGGAGGCTGGTACGCGGAAGTCCAAGTCTTCGGCGGCGAGGTCGACTGCATCCTTGCCGATCACACGGTAGGTGGTGTACTTACCGCCGGCGACGGAGACGAGTCCTGGCATGACCTTTGCTACGGCGTGGTTGCGCGACAGCTTGGTGGTGGTGTCGGATTTGCCGGAGAGCAGCGGGCGGAGTCCGGAGTACACGCCGACGATGTCGGAGTGTTGGATGGGCCGGCGGACTCGCTGGTTTACCTCGTCGAGGATGTAGTTGATGTCGGCGGCAGTTGGTGCGGGGTCTGCGCGGTTGAGGTCCCAGTCGGTGTCGGTGGTGCCGATGATCCAGTATTCACCCCATGGGATCACGAAAAGCACGGACTTTTCGGTGACAAAGCACATGGCTGCGTCGGCATCGAAGACGTTCTTTGGTACCACGATGTGTACACCCTTGGAGGCGTGGACCGAGAAGGGGCCGTTGCCGCCGGCGAGCTTTTCAATGTGGTCGTTCCATACGCCGGTGGCGTTGATGAATACCTTGCCGCGAATGGTGGTTTGTTCGCCGTTGTCGGTGTCTTGGAGGATGGCGCCGACCACACGTTGGCCGTCTTTTTCAAAGCCGACTACTTGGGTGGAGGGGCGAACATCTGCGCCGAGTTCGCCGGCGGTGCGTAGGACTGTCATGGTGTGGCGGGCGTCGTCGACAAGCGTGTCAAAGTAGCGGACGGATCCGACCACAGCGTCGTCTTTTAGTCCTGGGGCCATGGCGAGTGTTCCCTTGCGGGAGTAGTGCTTTTGCATGGGGACTGATTTTGCGCCGCCCATGAGGTCGTAAAGAGTAAAGCCGCCGAACATCATCACCCGTTCCCACACGTGGTGTGTGAGGGGGAAGAGGAATTTCAGCGGCTTGACCAGGTGCGGTGCGAGCGTGGACATGTTGAGTTCGCGCTCGTGGAGGGATTCGGCCACCAGCTTGAAGTCCAGCATGGCGAGATATCGCAGGCCACCGTGGAACATTTTTGATGATCGTGAGGAGGTGCCGGCTGCGAAGTCTCGGGACTCTACGACGGCCACTTTGAGGCCGCGGATTGCTGCGTCGAGGCCTGCGCCTGCGCCGACGGAGCCGCCACCGATGACGACAACGTCGTATTCTTCTTCACCGAAGCGCTGCCAGACGTCCTGGTAGTAGTCGGGGTTGAATGTGCAATGGGATTTCGTGGTCATAGTTGCCACACTCCTTCTTTGCGTCCGAGGTTTGCCCCAACCCTACTGAACCGTAAGTTAGGCAGACTAGACCCCTAGAGCAAGTTTTTTAGTTTCGGAGATAATAACAACTGGTAGCAGGTGATATAACCAGTGGTGGTGGCGGCAAAAACGGGCTGCGCGACATACGCCACACAGCCCGCTAACCCCCGCGATTTACACACTTTCAGGGGTAATAAAGTGCTTGTCTAAGAAATTAATTATCCCGTCTTTGTCCGGACGATCGCACCACTGCGCAGCCTCCCGCAACACCACCACCGGCGCCGAGACCACCGCAACACGATGCCCCGCACGCGCCAACGCGCCTGCCTCCGACGCATCAGCAGCACACACCAGCACCTCATCCCAGACATCCCCCACACACGCCTGCACAGCCGCCTCAACAGAAGCCTCAGGCGAAACAATCACACAACGATCCGGCTCCCCAGGCAATGGAACAACCCGTACTACCTGCGATAATTCCTGCCACAGGCCTGGATCAGCCCCCAATCCAGAAACAACACCATGGTAAGCGCCTTTCCATTCCACACCAAGGCCCAAGCTATCCACACACTCTTGCACGGCAGCGCGAAGCTCATCGGAAACCACACACTCATGCAACACAGAGACATCCGTATCACTCACCGTGGCGGCCACCGCACCAGCGCTAGCACTGACACAGATATCCGCACCCGACTCCTGTGCCACCTGACGGGCAAGCGCCACCACCCGATCCATGCCACTGATCGTGGTCAGCACCACCGTGTTCTGCTGAGATAACGCCGTCACCTGAGACAACACCGACGGCGACAGCGTGACCTCAGGATACGCAGCCACCGCACCATCGACGCTGAGCACCAACACGCGTGGCAACTCAGTCTTTGGTGCGTCCTTACGCTGCGGCAACCGATCCAACAACATGCTGACCTGGGCCGTCGCCTGCACCACCACAGGATTAACCTGACTAGCACTCACCGCCTGCCCATACAGATCAGCAACACTACGACGCAGCTGCTCACCGGCATCCATCACACGGTCTTTACCTTCCTTCGCGCTAGAGACAACCTCCTCAACGAACTCGTCGACAGTGTCCTTCAACACCGACAACGCCTTACCCGCATCCGCCTTCGCAGGCACCTCCCCATGCAACACGTCTTCCACACGGTGTCGAGCAGCGTCGACAGCACTCGCGCCCGCCTTCGTGGCCTGCTTAATCCGCTCCGTCAGCTGCGCGATCTCCTCCGTGAGCACGCGCACACGGCGACGCTCCTGCTCCACCTTATCGTCTTCCGCCTGAGCTTCGTCGAAAGTCGGCGCACCGCCGCCCAACCGCGCCGGCGCCCACAACGCACCAGGAGTAATCGGCTCCTCCGCCTGATAATCAGACCACACCTCCTCAAGTCCCGTGATCATCCGACGACGCAACTCCTGCGTCGCCTCATTCACATCACCCTCGGGGTACCACGCTGGGAACACCTTCATATGGATCGGCGAACCAGGATGAATCAGGTTCTTCTTTTGCCCCTTCGTCCACACCCGCTGCGACCCCACCACCATCACCATGATGATCGGAACCCCCGCAGCCTGCGCCATACGCACTGCCCCTGGGCGCAACGTTTTAATCTCAAAGCTGCGCGAAATCGTCGCCTCGGGGAAAATGCCTACCAATTCCCCCTTTTTGAGCATGTCCACCGCCTGGTCAAAAGCCGCGGTGCCGTCGATGCGATCCACAGGAATATGACGCATCTCCCGCAACAGCGGACCCGCAACCGGATGCTTAAACACATCCCCTTTAGCCATGTAGCGGATATACCTACGGAACTTCCTAAACGGATATCCCGCATAAATAAAGTCCAAGTACCCCGTGTGGTTAACCACCACAACAGCGCCGCCAGACTCTGGAACATTCTCCTCGCCCGAAATACGGATCTTGATGCCCTGGGCAGCCGTGATCGCGCGCACAGCACCAATTAGGTTGAGGTACAAAAGATCTTGGAACATGCCTGCCATGTTACGGGGTTGCTACCCCTGCAGCCACTCCCGCAATACCACCGCAATGCCTGCCTCATCGTTCGTCGGAGCCACCACATCAGCGGCACGCTGCAACTGATCGCACGCATTACCCATCGCAACGCCAGTGCCCGCCCAACGAATCATCTCAAGGTCATTGAGCATATCACCAAACGCAATCGCATCCGCAGGATCCACACCAAGGTCTTGCGCCACCACGTCCAACGCCGAAGACTTATTCACCCCAGGCTGCATAACCTCCAACAAACCGTCCGGCATGGAATAGGTCACATGGGCCACATCTGCGGGTACTACGGGGGCAACCAAGCGATGCATCTGCTCCGATGTCAGCGCATCATTGCGCAACAACAGCTTCACCGCAGAACGCGCTAACACCCGATCAAGCTCCACAGTGGAATGCTCAATGGACTCCCACGAGTGCACAAAATCTGGGGTAACCATGAAGAGTTCACCAGGCATGTCATGCGCAGAAACCCCTGCGCGTTCTACTCCCACACCGCAACCGCCGAGATCGCTAAGTGCCTCGCGGGCAACGCGCACCACGGTACGCATCGCATCGGGGGCCAACTCACGACGATGCGTAATGCGATCACATGCGGGATCATAAATCACCGCACCATTAGCACAAACACACAGTGTAGGTGGGGTGTATAGCTGATCGATGATCGGGTGGATCCAGCGTGCGGGCCGCCCCGTGGCCACAACGAACGACACCCCAGCACGCTGGGCAGCCGCAAGCGACTCTTTCACCGCACTGGGGATTCGTTCCCGAGAGTCGATGAGCGTTCCGTCGATATCACTGACAATAAGTGCGCTCATCGCTCTCCTTGCATATTTTCGTTGGGAAATTACTTCTTTGGCTCGAGTACTTCCTTGCCTACGAATGGACGCAGTGCCTCAGGAACGATCACGGAGCCATCAGCTTGCTGGTTGTTCTCAAGGATAGCGACCAGCCAACGCGTGGTAGCCAAGGTACCGTTCAGGGTTGCTGCAGTGTGTGCCTTGCCAGACTCGTCACGGTAGCGGGTGCGCAGACGACGTGCCTGGAAGGTGGTGCAGTTCGAGGTCGAGGTCAGTTCACGATAGGTGTTCTGGGTTGGAACCCATGCCTCAGTGTCAAACTTGCGGGCAGCAGAGGAACCAAGGTCGCCGCCGGCGACGTCGATAATGCGATAAGGCACCTCAACAGCAGCCAACATCTCGCGCTCCATGTTCAACAGAGCTTGGTGCTGCGCAACAGCCTCTTCTGGCTTGCAGTAAACAAACATCTCCAGCTTGTCGAACTGGTGCACGCGCAAAATACCGCGGGTGTCCTTGCCGTAGGAGCCCGCTTCACGACGGAAGCAGCTCGACCAGCCCGCGTACTTGATAGGACCATCAGACAAATCGATGATCTCATCCTGGTGGTAACCAGCCAACGCCACCTCGGAGGTACCCACGAGGTAGAGGTCATCGCGCTCAAGGTAGTAGATCTCATCTGAGTGAGCACCCAAGAAACCGGTACCGGACATGACCTCTGGGCGGACAAGCACAGGTGGGATCATCAGCTGGAAGCCATTCTCGCGGGCCTTTTGCGCCGCAAGATTCAGCATGCCCAGCTGTAGGAATGCGCCATCGCCGGTGAGGTAGTAGAAGCGTGCACCACCAACCTTGGTGCCGCGTTTGACGTCGATAAGCCCAAGCGACTCACCAAGATCGAGGTGATCCTTTGGCTCGAAATCAAAGGTACGTGGGGTGCCTACGTGCTCCAAAACGATGTAGTCATCCTCGCCACCAGCTGGGGCATCGGTAACAACGTTGCCGAACAGCATCTGGATCTCGTTGACCTTGGCCAACGCTTCAGCCTCGGCCTCCTCCGCCGCCTTCACGCGGGACTTCAGCTCGTTAGAGCCCTCCAGCAAAGCGGGACGCTCTTCTGGGGAGGCCTGGCTAATCTTCTTGCCAAAGGCCTTGTGCTCGGCGCGCAGGTCGTCGGCAGACTTAATGGCCTCGCGGCGCTTCTCGTCAGCCTCGAGGAGCTGATCCACCAGAGCTGGGTCTTCGCCACGAATGCGCTGGGACTCGCGGACGACATCAGGGTTTTCGCGGAGGAACTTTAGATCAATCACAAAACTTACACTACCGCGTTCCTGAGTTAAGAGGGTGGTTCGGACCGCCCCAGACCCCGCAATGGTTCAAAGATCACACCAGAAACCCTCGCTGGTTATGACCACTCACAGTATGCTCATACCTATGGTCGACACTCTCCTGGAGTTGCCCGCCAGGACCCTGACTGACGGAACCAGCACTCCAAAACACCAGCAACTCAGGGAAATTCTCGAAGAACTCTGCCGCACCCAGCTCAAACCTGGCGACATGCTCCCCGGCGAACGCGCCCTAGAGGAGCAATACGGAGTTAGCCGCATCACGGTACGGCGCGCCATCGGCGACCTCGTTGCCACCGGCCAACTGCGACGCAGCCGCGGCAAAGGCACCTTCGTTGCCCAAGCCCCCATGATTACTCGGCTGCAGTTGGCGTCGTTTAGCGACGAAATGGCCGCCCGCAAGATCGAAGCCTCCAGCAAGATCCTCGCATCCTCATGGTCTTCACCCAGCGCCGTCGTCCACGAATTTTTCGGCACCGAACAAGGCACCCCGCACACCCACCTCGTGCGCGTCCGCCTCGGCGGCGGCAAACCATTTTGCATTAACGACGCCTGGTACAACTCCGCCATCGCACCTGACCTGCTCGAAAACGACGTATATAAATCCGTCTACTCCATCCTTGAGCAGAACTACGGCGCATCTATTACCGGTGCCGAACAAATCACCACTGCGGTGGCCGCCACCCCAGAAACCGCGCGGATTCTCGGCGTGGATGTCGGCGAACCACTACTGAAGGTGGAACGCCACGCACACGCAGGAGAAAACCCCATCGAGTGGTGTTCCTCGCTCTACCGCACCGACCGCTTCGCGTTAAGGACGTTTATCACGAAGTAGTATGGGCGAAATGAGTTCGAAAAAGGTTGCAGGTTTTGCAGGTGTGGCTGCTCTCGTAGTGGCTAGCGGCGTAGGCGCGTACACGTACACGGCCTCGCAACACGACAACGCGGCCCACCCGCAGACCTCAACGTCTAGCGCACCAGCCGCCTCCGTCGGGTCGTTTACCAGCGCTGACGCTGGCGCATGCCTGACATGGGCAGATAACGGCGGCAAAGTATCCAAGTTCGAACAAACCGATTGCGCAAGCGAGCACCGCTTCGAGGTGTCCTCCCGCGAGGACCTCAACGCCTACCCATCCAAGGAGTTTTCCAACAACGCCGCCAAACCAGACCTGACCCGCCAGGCGCAGCTGCGTGAAGAACTTTGCCTCAGCCCCACCTTGCAGTACTTGGGTGGCACCTATGATCCGCTGGGACGTTACTCAATTGCGTCGATTCTGCCACCGCAGGATGCGTGGGAAAAAGGTGACCGCACGTTGCTATGTGGTGTGCAGGCCACGGATGATTCCGGCAAGGTGATCATCACCTCTGGTAAGGCCGCTGAGCAGGATCAGTCCCGCATTTTCGGTGCTGGGCAATGCCTGCTGATCGACGCCGCCAAGGCCACCCGCGTGGTCGATTGCCAACAGGATCACCAGCTAGAGATCACCTCAGTAGTAGACCTCCAACCGGTATTCCCACAGGTCATTCCGTCAATTGAGGATCAAGACAACCACCTACAACAGGTGTGCACCCAAGCAGCCCGCGACTACCTTGGTGGCGACGACCCTCTCTACTACTCAACCTTGCAGCCCTTCTGGACTACCCTGCCCGATAATTCTTGGTCAGGTGGTTCCCACAGCGTGAACTGTGCACTCGTGTTCGGCCAAGAGGACGGCAACTTCGGGGTGCTGCACGGCACCGCCAAGCACGGTTTTACTATCAACGGCCAGCCCCCTGCGCCTCGCCCCGAACGTGCTCCGATTGTCAACCCCGAGGTGCTCGAAGGCACGGCTCCTTAAAGCATCATGGTTGAGATTTCCCACGAGGAGTTTGAAACGCTTGTCGACGAAGCCCTCGCCGCCATCCCCGATCCCGTCGCCGACCGAATTACCAACCTTGCGTTTCTTATCAGCGACTATGCCGAGGAGTCCTCCTATATCCTCGGCCAATATCACGGGGTTGCGCTAACCGAGCGCACCTTTGATCACACCGGTTTTCTACCCGATACCATCACGATTTATCGCGAAGCCCTCAAGGATTTTTGCAGCTCCCGCGAAGAACTGGTCGAGCAAGTACGTGTAACGGTTATGCACGAGATCGGCCACTATTTTGGGCTCGATGAGGACGATCTGCACCGCCTTGGCTACGCCTAAACCCTTGTACAATTTGTATCCTTCGCGAGCGTAAAATGGTATCCTTTAGGGATGAAATACCAGCTTAGAGCCATTGATAATCAGCTCGATGAAATGCTTCAATTTTCCGGAGCAATTGCGGTCGAAGGCGTAAAAGGAGTGGGGAAAACAGAATCAGCAATTCGGCGCAGTGAACATCTACTGCAATTAGACCGCGCCGGTGATCGTCAGCTTCTTGAAGCCGATCCAGAATTTAGAAGTTTTTCTACAGGCACCATCCTCATCGATGAATGGCAAAGAATGCCTAAATGCTGGGATTTTGTTCGCAGAGGCGTTGATGCGCAGCGCACACCAGGGCGATTTTTGCTGACGGGTTCTGCAACGCCACAAGCAGGAATAGATACCCACAGTGGAGCAGGCCGTATCCTTTCTATCCGTATGCGACCCATGGCGCTTTTTGAGCGAAGAGAACACTCCGCCACTGTAAGCTTGGCTGATCTTTTTCTTGGCAATGCCCCTATTAGCGGAACGACAGATTTAACGCTTAACGACTATGTCTCAGAAATCGCACGAAGCGGTTTTCCGGGGTTTAATGAACAGCCACAACGCGCCATCAACGTGGAGTTGGACTCTTATATTGAAAGAATCGTTGATCGGGATCTCCCTGAGCAGGGGTACAACGTGCGCAATCGCGCAGGACTTTTAGGATGGATGCGCGCGTATGCTGCGGCATCGTCAACCACCATGAGCTATTCAGAAATCCTTAATGCTGCTACTCCTGGCGAAAGCGATAAGCCTGCCCGCAAAACTGCTGCACTATATCGCAGTAAGTTGACTGAGATTTGGATGCTCGACGAGGTTCCGGCATGGGATTTTGTACGATCGCCGCTTGCTGGACTCGCACAAGCACCAAAACACCAATTGGCTGATCCTGCCTTTGTCCTTCGTCTTTTAGGAGTACCAGCTAATCGTCTGGTTACAGAGCGTTATCGCCATTTTTTGAGCCCACTATTTGAATCATTAGCTACATTAAGCGTTCGAGTCGCCGCGGAATCACAATTTGGTTCCGTTAGGCACCTGCGTACTCGACGCGGAGACCATGAAGTTGATCTCATTGCGTCGAATCAAGACGGCGATCTTGTGGCTATCGAGGTAAAGCTCACCGCTGATGTGAAAAATGACGATGTCGCGCATCTTCACTGGTTAAAAGAACAACTGCCGGATGATGTGGTCGATATGGTTGTTCTGACAACTGGCAACCGCGCATATCGACGTAGCGACGGAGTCGCCGTGGTGCCGTTAGCACTATTCGGCGCCTAGCTCCGCCCCTGCCCAGGTAATCAGCTTCCACTGGCCGTATTCTCCGGTCGGGTCGATGACGATGGTGGAGGTGTTGTCGATGTAGTGCTGGAGTGCGAAGTCTGCGGTGACGTTGGTGCCAAAGCGGGTGACAATGCGCATGGCTGCGCCGTGGCTCACGATCAGGTGGTCGCCGTCGTGAGTGGCGAGTTCTTCGAGTATGGGGCGCATACGTTCTACTACTTGGCCTGCGGTTTCACCGTCGGGCATGGCTGCGCTGCGGTCACCGTTCATCCAGCTGTGGAGGGCGTGGGTGTATAGGTCGTGGGAGTGGCTGTCGGTGTTGCCTTCGATGGATCCGGCGTCGATTTCGCGGAGATCGGCGTTGATGCTGAGCGGGATGGTGCCCGGCGCGATTCCGAGGGTTTCTTCGTAGGATTTGAGCACTGCCACTGCTGTTTGCTGGGTGCGGATGGCAATGGAGCAGGTCACGGTGCGGATGTCTCGGCTCAGTGTTGCGAGACTGCGGCCGGCGTCGTCGGCTTGGGTGCGGCCGATAACGCTGAGTTCGGCGCCTGGGGGCCTAGTGTCGAGGACTTTTGCGGCGTTGGCAAAGGTGCGCCCGTGGCGCATGAGGATGAGACGTCCCAAGGTTGTTTCCTTATTTCTCTTTCTGATTAGGCACCGTTGCGGGCGGCTTCTACCCATGCGGATGCGGCCTGGGCGACGGTGGGGTCGACTGCTGTGACGGGTTGGCCGGAAATGGCTGGCCACGAACCGATAAATTTTAGCGCGTTGCACCGTGGGTAGAGTGCTCGGAGTGCTTCGGCGACGTTGAGGTCGTCGATATGCCCATTGATGTCCACGTGGAATCGGTAGGTTCCTAGGCCTTCTTCGATGGGGCGGGATTCGATTCGGGTGAGGTCTACGCCGCGCATGGCGAATTCGGAGAGTGCGCCGACGAGGCTGCCGGGTTCGTTTTTGAGCGTGAATACTACGGAGGTGCGGTCGTGGCCGGTGCGTGGGGTCGGGGTGTCGGCGTGTCCGACGAGGACGAATCGGGTGCGAGCGCCGGTGACGTCGGCAACGCCGTCGGCGATGATGTTAAGACCGTACACGTCAGCGGCGCGGGCGGGGGCTGCGGCAAAGTCCACGATTTTTTCTTTGGCCATGCGGGCGGCTTCGGCGTTGGAGGATGCGGGGACGAATTCGGCTGCGGGTGCGTTGGCGGCAAGCCAAGTTTTTACCTGTTGGTAGGCCACGGGGTGGGTGGCAAAGCGGCGTAGGGGTGCGCCGGTGCGCTGCATGATGGCGAAGGCGATGGGGAGGTCGAGTTCGTGGAAGATGCGCACGCCGTCGATGGTGGCGAGTGCGTCGAAAGTGGGGGTGACGGGGCCGTCGACGGAGTTTTCGATGGCAACGCAGGCGTAGTCGGCTTGTTCTGCGGCGACGGCGGCGATCGCTTCGCGGGGGTTGGCGGCCGCAATGGTGCCGACGGATTCTAGTCCGAGGCGGGTGGCGAATTTCCACAGTGCGACTTCGGTGAATGTTCCTTCTGGCCCGAGATAGGCAATCCTCATGCGTCTTACTCTATCTGGCCGGTAAGGTATTCGTCATGCCTATCCATGAGCAGATTGATCTCCTTGCAGCACAGGTGGCTCAGATGTCTGCTTCAGATCACGGTTTTTGTTATTTTGATGCGGATGCCGCCCATGAGCAGGCAGAGCATGCGCGTGGGCGGTTGTCGGGGTGGATTATCCCAGCGAAGGATTTGTCCGATGTGGCTGGTATGCCCACGACGTTCGGTTCGCATTATCGGGTAACGCACCCTGATAAAACGGATGCGTTTGTGGCACGGTTTATGGCTGAGGGTGCGGTGGTGCCGGGTAAGAGTCTGACGCCTGAGTTGGGGTTGACTGCCTATACGGAGCCGGTGGATCAGCCTGCGCCGGTGTTTGAAGGGCATACGCCTGGTGGTTCTTCTGGTGGTGCTGCTGTGATGGTGGCTCGTGGTTTGGTGCGAGCTGCGCATGGTTCTGATGGTGGGGGTTCGTTGCGTGTTCCTGCTGCGTGTTGTGGGTTGGTGGGTTTTAAGCCGCCGCATAATACGGCGGGGGCGGTGCCGGTGACGCAGGGTTTTCTTACGCGCACGCTTGCCGACGCTGCCTTCCTCCACGCCATAACCCCAGTTCACCGCCCGTTGCGGGTGGGAGTATTAACGCAGCCGGTTCATGCTGAAGTTTCTGTTGCGGATCCGATGTTGGCGGCGGTGGATGCTGCGGCTTCTGCGTTGTCGCGGGCGGGCCATCAGCTGGTTGAGGTTCAGCGTCCGTATGGGGATGCGCCATTTGCGGCGTTTTCTGACATTCTTGCGTTGCGCTCTGCCAAGATTCATGGGCAGGCGTCGCCGTTGGTGTCGTGGCTGCGGGATCGTGGTGGCCGCATTGGGGGGCGTCGAAAAGCGAAGGCGATAGCCGAATTTTTGTCGGTGCGCGCGCAGCTTCTTGCCGCCTGGGATGTCGATGCGGTGCTCTCCCCTGTGTTGGCCTTCGACCCGCCCGCGGTGGGCTACTTTTCGGCGATGTCCCCTGAGCAGGATTTTCATGCCCAAACCCAGTGGACTCCGTGGGCCACGATGTTCAACATGTCTGGGGCGGCGGCGCTCAGCATGCCGTATGCGGGGCGCAACATCCACCTAGGGGCGCTTCGTTGCAGCGTACCGGAACTTTTCGGATTGGCAGGTGACTTATGAGCACTCGCCGGCTGCGTTACGAGGTCGCGCTAGTCCTCGCCTTGACCTTCGGTATGGCGGGGCTGCGTTCCATTTTCACGCTTATCGACGCCCTTTCCACCCCACTGAACACCCAAAGCGTGACGCTCAACGCCCCACGCGCCACCGCCGCCTGGCTCGACTTTGCCCTCCAACTATGCGGCGCTGCCACCATCATGACGTGGGGATTACTTGCCCTCTTCCTCCTCGGCGAACGCCTAGAAAAACCTCGGGGCGCCGACTTTAGCTGGGGTGTGGGCCTGGCCGCCCTCATCGGAATCCCAGGTCTGGGCTTCTACTATGCGGCGGTTCACCTCGGGCTAAGCAAAGAAGTTATCCCCTCAACACTGGAACACTTCTGGACCATCCCCGTTTTGCTGCTGTTTTCTTTCGCCCACGCCTTCGCCGAAGAAATAGTCGTGGTCAAATGGCTGAGCACAAGGCTCAACCAACTCGGCCACGGCCTTATTTTCACCTTGGTGGTCAGTGCCCTTTTGCGAGGCAGCTACCACCTCTACCAAGGCGTTTCCGCAGGTATCGGCAACGTAATCATGGGGCTTATCTATGGCTGGTTTTATCTGCGCTACCGCCCCACATCCATCTGGCCACTGATCATCGGCCACTTCCTTATCGACGCAGTCGCCTTCGTCGGCTATACGCTTGCCACGATGTTCAACATCAACGTTTCTTGGTAA

Protein sequences of DBSCAN-SWA_2

>NC_016786|2231253:2282578|2233750_2235544_+|WP_014302516.1|holin|DBSCAN-SWA
MSLRNRLRTSISKHDTDGEFIQDRTRDVVIVGGGSAGSVLANRLSEDPDTSVMVLEAGRSDSLWDLFIHMPAAFSFPIGNKYYDWAYESEPEPHMNGRRIYHARGKVLGGSSSINGMIFQRGNPMDYEKWGALPGMQNWDFKHVLPYFNKMETALGADANDPRRGHTGPLKLTRGPATTPLFQAFFRSVQEAGYNLTNDVNGYRQEGFAPFDRNILKGKRLSAARAYLHPVMDRTNLEVRTRALTTRILFNEAGTQATGVEYEWKGKKRRVMAKKVILCGGAFNTPRLLQVSGVGDREVLEKAGVDVVKHLPGVGANLQDHLEVYVQYNVTKPVSVQPNYKMTRRPFIGLQWLLTKKGPVASSHFEAGGFARSNDDEAYPNLMFHFLPMAIRYDGTQPEGDHGFQFHVGPMYSDTLGHVHITSPDPKAKPEIIFNYLATEQDRREWVEAVRVSRRLLDTDAMKEYTDGEISPGADVQTDEEILEWVRNDAETALHPSCTAKMGSADDAMAVVDPENMQVHGIDGLYVCDASAMPIITNGNIYAPVIMMAEKAADLIKGIKPLAPIDVPFYKAKQGMPLYAEDEKVRDHTKAIPGADH
>NC_016786|2231253:2282578|2276479_2277481_+|WP_014302545.1|DBSCAN-SWA
MGEMSSKKVAGFAGVAALVVASGVGAYTYTASQHDNAAHPQTSTSSAPAASVGSFTSADAGACLTWADNGGKVSKFEQTDCASEHRFEVSSREDLNAYPSKEFSNNAAKPDLTRQAQLREELCLSPTLQYLGGTYDPLGRYSIASILPPQDAWEKGDRTLLCGVQATDDSGKVIITSGKAAEQDQSRIFGAGQCLLIDAAKATRVVDCQQDHQLEITSVVDLQPVFPQVIPSIEDQDNHLQQVCTQAARDYLGGDDPLYYSTLQPFWTTLPDNSWSGGSHSVNCALVFGQEDGNFGVLHGTAKHGFTINGQPPAPRPERAPIVNPEVLEGTAP
>NC_016786|2231253:2282578|2243182_2243767_-|WP_014302521.1|DBSCAN-SWA
MSEKLVLNSGKCFLHEVLCRREEKEYRQTRANLRRGADTTTEVYAFPYVYPQLPQEATTQERLVLMRVAALAAEFGNIPAVGSDTPAKSLGRWAYEVSRQRMLDRQQQVAFNPKKLDVVGERLAYLHTQDFEEAVRAVSRLMSIASSLSNVPAFDYIALYSLFSYWGNGISEKSQRVRMRVLQDYYGSFGSLIE
>NC_016786|2231253:2282578|2253567_2253717_+|WP_014302528.1|DBSCAN-SWA
MTSRIIGSLAALTVAIGCTIVAPAIWPITTALATISIINIRTQLRKEKE
>NC_016786|2231253:2282578|2254757_2255804_-|WP_014309675.1|DBSCAN-SWA
MAMNSETAGKEPNVVSTDAKHSTGTSSNAGTGESSAKKKAQTTIAAIVMLLCGLLGLVILFYPVVSTQLNNYEQSKLARQFGADAAQADPAVVAAALDAAHAYNDSLENGPLQDPWTGGDSTKDPAYQAYEKLLGEYPAMAQISIPAISVNLPVYHGTSDATLLKGVGHLYGTALPVGGLGTRSVLTAHSGIQKSTFFDNLEKVKKGDAIYVRNIGETLKYQVRDTEIIRPAEIDRIQPIPDRDLITLVTCTPYGINTHRLLVTAERVPMEPGEADRAFAGDGIVWQWWMKLAIGVLVVILLLTGWLIIRILRARKFAKKTAGADAAKSVEPSDTEASLSTSAAEESQ
>NC_016786|2231253:2282578|2281861_2282578_+|WP_014302551.1|protease|DBSCAN-SWA
MSTRRLRYEVALVLALTFGMAGLRSIFTLIDALSTPLNTQSVTLNAPRATAAWLDFALQLCGAATIMTWGLLALFLLGERLEKPRGADFSWGVGLAALIGIPGLGFYYAAVHLGLSKEVIPSTLEHFWTIPVLLLFSFAHAFAEEIVVVKWLSTRLNQLGHGLIFTLVVSALLRGSYHLYQGVSAGIGNVIMGLIYGWFYLRYRPTSIWPLIIGHFLIDAVAFVGYTLATMFNINVSW
>NC_016786|2231253:2282578|2242068_2243127_-|WP_010935664.1|DBSCAN-SWA
MSRHLTFHIITNVPYSNLNRDDSGTPKRVSLGGALRALHSSQSIKRGIRTKYELASLDTSIRSGKLVEEVVRVGLDLKPEVDEKLLRKGAAKIIGSLTKGESSEGESARSAWMSREEITTAAQTVIDGQEDSDFIQDNRTGSLAIAAFGRMFANAPKKNTEAALAVSPGVTTHAVTIETDYFSTVDDVREREHDSGATFLGVARYVNGTFYRTVSIDKEQLRESWSGFGQEESVDNLRELIKAIVYGAPRGKENSTAPYTLPSLVFAEEQHYRTAYSFETPVLVGKDGGFEFPTICELDRQFARARSFDKGNFGPLEVVSGTAVLEDEQFEGVQRSDLNGLIEAVVNWVTND
>NC_016786|2231253:2282578|2258704_2262832_-|WP_014302534.1|DBSCAN-SWA
MTAWSLKGRNDFLQRLAALAAVPIVAVSLMAGSVSAAAQDEVGLDAALADSDSPPLEPKPQDLESVEGEEEAPAPEELESIAGTFATAAAMGTTTGSGNLKCDEGYYYAIHKWGEVLQLQEQNGAWGRNPINRQSYSFRSGSSPSGDWNGLGVSKDGSTVYAYNRYRYENSSTYGWVVTQVQIGDIVNGQRNVSNVYRLETPSGLIAGAVAPDGTYYFGGYRFSGDVKAAKKAVYTNNPPVTNWTYSYDSSLGYYYYNGTDGRRYYYSSAGFWSNSGEFLGRYWSPAVAERSREFVLYKYFGGQITTVGIVPISTPVQNSTSAVNGDFAFDSSGNMYLLFHEGGTTNVQLIPVLADQLEGTGTTRQIIPQPTTTIQVKPNDLGPSYFNGVSFTVDGYLMIEDGTVNARQSTAYFYKVDPTTGNVVAQETFNNDGTHEVYMDRDGGYAAWLYGGQSDLASCATFSTLELKKTFPTGRAAKADQVELQISRGTGTNTNEKLAWTSTTGEVIGEQPVVAGPVIASPDEVFRLREVPSVSEGTGKTRLSYYKSNLTCKDTLTGAFLPSTYIKSVDNTSSTKREWDVTIPSYSAWQLQCMYENTPVKGDLAWTKVGKESPEDTSVIELGGSVWSLLDSNKQVITSPISYEKIKDCDANTDAGCLKVDKNKSSAKFLVTDLPYGTYYLREDQAPDGYKPLSDPIKFSFDVKGMTILESPAELDQRWKELAKKNTDTNVVDLGQILNLKPQGTVTWKKTDAATGAILHDSTWKLTRLTDASGQKIAAEALVDGRDQFEIKDKTSKTEDATRDTNEATGEFKVEDLPYGKWRLEEVEAPDGYRIVGANAYEFTVNKAKKDVEAVPGGAIKNYKARIEWSKVDAADEKNALAGSEWQLTGPDGKELSVKDCVASECVPEVNDIDPGKGKFSVAELGNGEYTLKETKAPEGYLVTEKTYTFKITDTGYSIDGNTEKKFPVPSSGTNYIPLSIGGITNDKDAAKVHWSKVDAAATSTLLGGSEWFIVPKTSTGALDEVNAIKVTDLVAGARAEKDTNTAAGEFTVELPLGTYVLKETKAPAGYLISDEAKNGKEFTLTRDNLTKVLEFGSVTNKKIEAGVTWKKVDATDATKLLGGSEWTITPYKADGTLDTANAKKVVDKTPNAAGVLDEDPVAGQFKINALPAGKYRLEETKAPEGYVLADAASAGVDFTVDDSKAGAVVDLDAIKNERMDGVVTWTKLDQSGKALHSSEWTIVKVTADRKPIDGAVAIQVTDCQADAASKCTGPDIDPAGGAFKVDGLEFGEYKLVESKAPAGFVVDATEHYFTISKNGEEVVAGAFKNELGKGVKLPLTGGLGAFKFLIAGGLLGVLSAAMGGAHVMRRRNS
>NC_016786|2231253:2282578|2249959_2250274_+|WP_010935670.1|DBSCAN-SWA
MFAVLYLQAAPDHLLGYVTRFLTEADTSIYVGNVSKNVASNLWIRVTEAIKDAHATMIVSDNSREQGFSIMTTGDSTLQVLDADGLSVLASRPGRAAVKLHGLQ
>NC_016786|2231253:2282578|2268985_2269726_-|WP_014302540.1|DBSCAN-SWA
MTALQAFGWEFLGTALLLLLGNGVCAVNSLRTSAGKGTGWVLIAFGWGMAVFVGASVASPSGGHLNPAVTIALAIKGSTPWNLVGGYVLGQFLGAMFGAILCWLTFKQLFDANNTDENGNVTGANRTTGGIFFTGPAHNQNGWNMVTEFIGTCVLLLFIFFGPTGGDLGPMTYFAVAFVIVAIGLSLGTPTGYAINPVRDLGPRLMYAFVLPIKDKGSANWGYAWVPIVGPMLAAVFCGVLATVVL
>NC_016786|2231253:2282578|2263696_2263960_+|WP_157891399.1|integrase,transposase|DBSCAN-SWA
MNLGLLAPNRLWVADITYVRTRKGFVYTAFVTDVFSRRIIERVLSDSMSTSSLAAAGVEPGDRVCQGNDGFDSPLRPRLTICEHCLQ
>NC_016786|2231253:2282578|2246367_2248998_+|WP_014302523.1|DBSCAN-SWA
MNPHEELWAKQKGLAKPYPLLAHLLDSAAVAGALWDHWLRQDLRQMFIEELGSNAREIIQFVVGSHDIGKATPLFQYQKAQKGEVWDSIRYAIDRTGRYQKPLPSSYLVKKTSGGPNRHEQWSSFASKNEYLKPSAAAKENWIGLAIGGHHGRFEPVGYGRHQRKAAEDLAKSGWSAAQQDLLRALEKASGITRASLPSELSPELTLVLSGLTILADRISSTESFVITGARMIDDGTLHLATPIDWLKTRKLDSEKHVAKTVGIYHGWNNHESAIHSILKGYDPRPLQTIALQNQVGLLNLMAPTGNGKTEAAILRHSLKENDRLIFLLPTQATSNAIMRRVQGIYSDTPNAAALAHSLASVEDFYQTPLSVFDDHYDPSKEQFESSMSGGLYPSSFVCSGAARLLAPICIGTVDQALATALPGKWIHLRILALANAHIVIDEVHTLDHYQTALLENILPILAKLKTKITFLTATMPSWQRTKLLTAYGGEDLQIPPTVFPAAETVLPGQFNRTLIDSDSTTIDFTMEETSYDHLVESHVKWHQTTRLNAPHARIGLICNTVKRAQEIAAALEKTNDRIVLLHSRMTTEHRRRSAELLESLLGPNGNRKTITVVGTQAIEASLDIDLDILRTELCPAPSLVQRAGRVWRRNDPYRSSRITADHKPISVVFIAEAKDWQVLPYLRAETSRTQRWLEKHNQMFLPQMAQEFIDAATVDLDTATSEMDLDALALMGIHLMKADGAKARIQDVLNSDSKVSDFALLTSKNEIDEAQTRLIEEGTHLRIILGDENESIPGGWKHGLSSLLKLKASDRESLRTALLASIPLLVSEKQKQLLYQHNLVPLSSSKTVLAGFYFLPKAQNFYSKNLGFIWPEEKD
>NC_016786|2231253:2282578|2256933_2258601_-|WP_014302533.1|DBSCAN-SWA
MSVKRTTIGRRLACAVGASALILSGAGFAAPALAQTEPSANVAAANYGNIDFTKQGRIIINKHLHQEDGSSAVGDPATGDYKGTPTEGLNGVTFKIYKIKNIDLLKQEGWEAVNKYNIPADPTKDDNLKEVDTVTTANGGKATTKDLSVAAYVVYETDAPADVIDRASPFVVTLPYPDTTANDDRLGERTNTWLYDVNVFPKNGKTKLNKTVEMQNTYGLNVGSEVHFPVTAVIPKVAEDKVFKYFQVIDPMDPRFDQESLGVESVTLNGKALESDDYTVAGDGSRVIVSLTSQGLGKLKNAAGQELKVVFKGKLKSLDNGKPEEFGRILNQAYVYSDTESNPGQSTPPSTPPIWPVTTPPDTPPVTTTPPGGTPLVKQFWGDLRILKVDKGDGKTGLEGAKFKIYPATKPYPENGTCGPEYDKNAPVQVNGTGNGNDLVVTSDKNGNVHFEGLFVSDDQNDPGKSAAQRCYVLVETEAPTGFVTPKDGTVFPVAVKIGQTATTTYDAKVENVKRDTPDLPLTGGKGVLFLMIAGGLLLLVAVGAGFVFVRRINE
>NC_016786|2231253:2282578|2277886_2279134_+|WP_014302547.1|DBSCAN-SWA
MKYQLRAIDNQLDEMLQFSGAIAVEGVKGVGKTESAIRRSEHLLQLDRAGDRQLLEADPEFRSFSTGTILIDEWQRMPKCWDFVRRGVDAQRTPGRFLLTGSATPQAGIDTHSGAGRILSIRMRPMALFERREHSATVSLADLFLGNAPISGTTDLTLNDYVSEIARSGFPGFNEQPQRAINVELDSYIERIVDRDLPEQGYNVRNRAGLLGWMRAYAAASSTTMSYSEILNAATPGESDKPARKTAALYRSKLTEIWMLDEVPAWDFVRSPLAGLAQAPKHQLADPAFVLRLLGVPANRLVTERYRHFLSPLFESLATLSVRVAAESQFGSVRHLRTRRGDHEVDLIASNQDGDLVAIEVKLTADVKNDDVAHLHWLKEQLPDDVVDMVVLTTGNRAYRRSDGVAVVPLALFGA
>NC_016786|2231253:2282578|2277487_2277835_+|WP_014302546.1|DBSCAN-SWA
MVEISHEEFETLVDEALAAIPDPVADRITNLAFLISDYAEESSYILGQYHGVALTERTFDHTGFLPDTITIYREALKDFCSSREELVEQVRVTVMHEIGHYFGLDEDDLHRLGYA
>NC_016786|2231253:2282578|2267446_2268967_-|WP_004567377.1|DBSCAN-SWA
MNQPQYVAAIDQGTTSTRCIIFDHNGQQVGVGQYEHEQIFPQKGWVEHNPMEIWANTRQAVGTALAESDVSREDIVAVGITNQRETTVVWNKTTGEPIYNAIVWQDTRTNSICSELAQGDPARWQKRTGLLINSYPAGPRLKWILDNVEGARELAENGDLLFGTIDTWLLWNLTGGAEGDNGQPAVHATDVTNASRTLLMDLESLQWDEELCAALDIPMQVLPEIRPSVGNFGQVRARGSLAGVPIRAILGDQQAAMFGQACFRPGDAKCTYGTGLFLLENTGKTPKHSENGLLTTVCFQLEGEKPVYALEGSVAMGGSLVQWLRDNLQIIPNSPAIENLAREVPDNGGVYIVPAFSGLFAPRWRPDARGVIVGLTRFANRKHLARAVLEATAYQVREVIDAMVADSGVELTEMRVDGGMVMNELLMQFQADVLRSDVTRPKNIETTATGVAYAAGLGVGYWDSLDVLRSMNEVDKTWHAKMDADKIDELLAEWNKAVERTYNWEN
>NC_016786|2231253:2282578|2250819_2251335_+|WP_010935671.1|DBSCAN-SWA
MAQGEVNVTIVGNLVADPELRFTPNGVAVTSFRVASTSKKYDSRSNQWVDGDAVFLQCNIWHQAAENVAESLTKGMRVIVTGRLRQRSYETREGEKCTVMELEADEVGPSLRYASASVMRNERNSGGNGVGSQPSTGGFGGQVSQPQSGGQSQGSDGWNNPAPLGDDNPPW
>NC_016786|2231253:2282578|2275704_2276478_+|WP_042382035.1|DBSCAN-SWA
MTTHSMLIPMVDTLLELPARTLTDGTSTPKHQQLREILEELCRTQLKPGDMLPGERALEEQYGVSRITVRRAIGDLVATGQLRRSRGKGTFVAQAPMITRLQLASFSDEMAARKIEASSKILASSWSSPSAVVHEFFGTEQGTPHTHLVRVRLGGGKPFCINDAWYNSAIAPDLLENDVYKSVYSILEQNYGASITGAEQITTAVAATPETARILGVDVGEPLLKVERHAHAGENPIEWCSSLYRTDRFALRTFITK
>NC_016786|2231253:2282578|2280728_2281865_+|WP_014302550.1|DBSCAN-SWA
MPIHEQIDLLAAQVAQMSASDHGFCYFDADAAHEQAEHARGRLSGWIIPAKDLSDVAGMPTTFGSHYRVTHPDKTDAFVARFMAEGAVVPGKSLTPELGLTAYTEPVDQPAPVFEGHTPGGSSGGAAVMVARGLVRAAHGSDGGGSLRVPAACCGLVGFKPPHNTAGAVPVTQGFLTRTLADAAFLHAITPVHRPLRVGVLTQPVHAEVSVADPMLAAVDAAASALSRAGHQLVEVQRPYGDAPFAAFSDILALRSAKIHGQASPLVSWLRDRGGRIGGRRKAKAIAEFLSVRAQLLAAWDVDAVLSPVLAFDPPAVGYFSAMSPEQDFHAQTQWTPWATMFNMSGAAALSMPYAGRNIHLGALRCSVPELFGLAGDL
>NC_016786|2231253:2282578|2237587_2238430_-|WP_041727284.1|DBSCAN-SWA
MQIIPWQHDIANLHLPERDSLILMPCATRTVGRRLTARNIGLADTRGNCDISWPGVMIKIYGQQAVTSARSHQKTAVLFSVRRAQVAAMILTYPWLLSEPVRVIARYSGVSVGTVSNALKIFQKAGYLAETMDGHRLVNAELFLSAWARAYPTGLGADLELLRGKAQQLPPYNLEHLGVKASESAVSDHISDGQSASLYLGEETFSPKVIKELRLVKNPAGTITLRRAFWNTIDVKEIPEAIVYADLLNSDDARLWDVAQVIKAIILKRARGDWLGDQDG
>NC_016786|2231253:2282578|2279119_2279746_-|WP_014302548.1|DBSCAN-SWA
MRHGRTFANAAKVLDTRPPGAELSVIGRTQADDAGRSLATLSRDIRTVTCSIAIRTQQTAVAVLKSYEETLGIAPGTIPLSINADLREIDAGSIEGNTDSHSHDLYTHALHSWMNGDRSAAMPDGETAGQVVERMRPILEELATHDGDHLIVSHGAAMRIVTRFGTNVTADFALQHYIDNTSTIVIDPTGEYGQWKLITWAGAELGAE
>NC_016786|2231253:2282578|2255787_2256744_-|WP_014302532.1|DBSCAN-SWA
MVTTASPRSTGPDNPDAQPKRRWVFSGLALFACITALAGLMLGLYPSTAAWFNAREQAKLVDLYDSKIENATPLSAEQLLELAHRYNDRLTVGAALDPWANVPRGAGKEDGDGMAYKDQLRVDRTDVMARIRIPSIKVDLPIYHGTSDDTLKKGAGHLEGTSLPVGGPRTHSVITAHRGLAEATMFTNLNKVGVGDRFTIEVMGEVLTYEVRETRVVSPEDTRFLQTQDDRDLVTLVTCTPLGINTHRILVTAERITSTPQSDIDAARQASQIGFPWWAVIFAVGFSFIALFFWRSGYMIPPKKKEEDIEGEADGDEL
>NC_016786|2231253:2282578|2251353_2251551_+|WP_014302525.1|DBSCAN-SWA
MRKDDLKEAALVAMREYYVARDVLAEKRSIAKKALKTAKLCGVTNRELAEELPTSESALSRFSAG
>NC_016786|2231253:2282578|2241347_2242076_-|WP_010935663.1|DBSCAN-SWA
MIESAYIRLSGPLQSWAGSVVTGNIVRTEPRPTFSSLRGLLAGALGARRGEWPNWLDDVEFWVREDRKPIVVNEFQTINPLPEVETFRKRLLIAQGRKANSAKALTFTPDAQGGTSIVNRTYLADGEYLVRVTSSTHMDEIENAFSSPAFVTYLGRKAFYAEFPFYLGRGSADAFEKIPVVHRNSDESKAQKSQVVLATKFGRYFPVSGLHSKIQIPVVESDDARLTQISDLLDIRRTAANR
>NC_016786|2231253:2282578|2271645_2273478_-|WP_014302542.1|DBSCAN-SWA
MAGMFQDLLYLNLIGAVRAITAAQGIKIRISGEENVPESGGAVVVVNHTGYLDFIYAGYPFRKFRRYIRYMAKGDVFKHPVAGPLLREMRHIPVDRIDGTAAFDQAVDMLKKGELVGIFPEATISRSFEIKTLRPGAVRMAQAAGVPIIMVMVVGSQRVWTKGQKKNLIHPGSPIHMKVFPAWYPEGDVNEATQELRRRMITGLEEVWSDYQAEEPITPGALWAPARLGGGAPTFDEAQAEDDKVEQERRRVRVLTEEIAQLTERIKQATKAGASAVDAARHRVEDVLHGEVPAKADAGKALSVLKDTVDEFVEEVVSSAKEGKDRVMDAGEQLRRSVADLYGQAVSASQVNPVVVQATAQVSMLLDRLPQRKDAPKTELPRVLVLSVDGAVAAYPEVTLSPSVLSQVTALSQQNTVVLTTISGMDRVVALARQVAQESGADICVSASAGAVAATVSDTDVSVLHECVVSDELRAAVQECVDSLGLGVEWKGAYHGVVSGLGADPGLWQELSQVVRVVPLPGEPDRCVIVSPEASVEAAVQACVGDVWDEVLVCAADASEAGALARAGHRVAVVSAPVVVLREAAQWCDRPDKDGIINFLDKHFITPESV
>NC_016786|2231253:2282578|2248999_2249959_+|WP_010935669.1|DBSCAN-SWA
MPYSHDAIAFSTIPASHQIRLEDRLSFLYLEYCLIRQDRTGVIAIQNGHNESSDEEEKLEPQILRIQLPVASLAVLCLGPGTSISNAAMTSCTRSGCTVIFTGGGGVNAYSHATPLTSTAKWAIAQACLVSNTEYQKKAALAFYKRQFGGNAITGGSISVMRGLEGRIMRNTYRENAKKAGIRGFKRDTKAADPVNVGLNISNSILYGAAATVCTAIGVNPALGIIHRGDTRSLLFDLADLYKASIVIPLVFSHAKDEDPVTNIRRHLRREIHSRKIMAGMLEALMEVLTPYLPNRNDDRLIGDSDEVKGHIQYGKEIN
>NC_016786|2231253:2282578|2231253_2233479_-|WP_014307698.1|holin|DBSCAN-SWA
MKEDAHTDGDASSVDASTSLGGKMQGVKEAAPKVLVGSYKAGAGGVVGESSAGGNDIPEPTTNWPVFGASAVGIIALTLWAFFAREKAATALGAVTEWISTNLGWFYILTATVVIVFVIGVAVTRTGSIRLGPDHSRPQFKLFSWSAMLFAAGIGVDLMFFSVAEPVAQYYGPPVGQGETREAAEQAVVWALFHYGMTGWALYCLMGMAFGYYAYRLNMPLAIRSALYPLIGKRIHGAVGNCVDIAAMLGTIFGIAASLGIGVVQLNYGMKVLFGVEEGPTWQIILVVVSVAVATLSAVSGVDKGIKVLSEINVLLAIALMIYVVIAGKTAFLLDGLVMNIGDYVSSLPGMTMDTYAFSDDPEHTKAWLGAWTLFFWAWWVAWAPFVGLFLARISRGRTLRQFVFGTLSIPFLFIVLWMSFFGNSALAIVRGGNDAFGHEAAANPQRGFYDLLATYPGAIFLVGLATMIGLLLYITSADSGALVMSNFTSTTHHSSQDGPVWSRIFWAVVVGALTIVMLQLDGIATVQSATVVMGLPFTIVIYLVMAGLVRCFRLEQTQKDARVVSVHAAMSGRSTIGEQQGHSISWRRRLSRANTWPSAAKAQAYITNVATPALTQVAEELCRKGINARLVTTKTQAVEGLDLIVEMGSEQNFRYQLFPVCNPVPQFTRKANASEKETYYRLEVCDLTGSLGYDIYGYTQEQLIDNVLDLYERHLEFLHMHSDLPGSSDLSDGATPPLFS
>NC_016786|2231253:2282578|2252053_2252731_+|WP_014302526.1|DBSCAN-SWA
MDGLRLLARQDFAQWWKTTGDLNRLRDHFYEIQRLYGEQAAAAAVDYLVLNRSLDDDFAGLPFPETADPVKYEQASASFSWVMQTVASHQSEIDRVAAKQRLFGVLDRLVTLPARDTVVLNVQRDHTAYARVPEPGACAFCLMLASRGAVYKKSTVGMVNKYHDHCRCLGIEVKRDGSDLPRINRDLERVWSNLSHDLGLPLTLRILIGIYANSKRLSSGLRFNG
>NC_016786|2231253:2282578|2274347_2275607_-|WP_004567386.1|tRNA|DBSCAN-SWA
MIDLKFLRENPDVVRESQRIRGEDPALVDQLLEADEKRREAIKSADDLRAEHKAFGKKISQASPEERPALLEGSNELKSRVKAAEEAEAEALAKVNEIQMLFGNVVTDAPAGGEDDYIVLEHVGTPRTFDFEPKDHLDLGESLGLIDVKRGTKVGGARFYYLTGDGAFLQLGMLNLAAQKARENGFQLMIPPVLVRPEVMSGTGFLGAHSDEIYYLERDDLYLVGTSEVALAGYHQDEIIDLSDGPIKYAGWSSCFRREAGSYGKDTRGILRVHQFDKLEMFVYCKPEEAVAQHQALLNMEREMLAAVEVPYRIIDVAGGDLGSSAARKFDTEAWVPTQNTYRELTSTSNCTTFQARRLRTRYRDESGKAHTAATLNGTLATTRWLVAILENNQQADGSVIVPEALRPFVGKEVLEPKK
>NC_016786|2231253:2282578|2235730_2236894_-|WP_014302517.1|DBSCAN-SWA
MSDFDLIVVGSGLFGLTVAERAASQLGKKVLIVEKRSHLGGNAYSEAEPETGIEIHKYGAHLFHTSNKRVWDYVNQFTAFTGYQHRVFAMHNGTAYQFPMGLGLINQFFGRYYTPDEARELIKEQSAEIDSKDATNLEEKAISLIGRPLYEAFIRDYTAKQWQTDPKELPAGNITRLPVRYNFDNRYFNDTYEGLPVDGYAQWLSNMADHENIEVRLDTDWFEVREDLRAQNPEAPVVYTGPLDRYFDYSEGHLGWRTLDFETEVLNTGDFQGTPVMNYNDAEFPYTRIHEFRHFHPEREDRHPKDKTVIMKEYSRFAEEGDEPYYPINTPSDREMLFKYRELADAETESSKVYFGGRLGTYQYLDMHMAIASALSMFDNKLVDALK
>NC_016786|2231253:2282578|2245681_2246368_+|WP_010935667.1|DBSCAN-SWA
MNTKIHLVKLPVHIALSVPAKNKPRKGWELTDPSFRHRAVMALFPDTDSPLPRKSVDILFRFEQLAGQPPFFLIQSTVAPKQVDNLDSEVQHRTVSLRRFSPKSAVRFRISINGIRRQTTEHNGRKRITTSPVPFDSDEKAPSHITRMTPWVQKKLNGALRNVEILNHQREVIGTKHRGGKAASMTIQIDTVDGFGIVEDPELLNELILHGVGRAKAYGCGLLSVSEI
>NC_016786|2231253:2282578|2264088_2264223_+|WP_014302538.1|transposase|DBSCAN-SWA
MVDVEVATFEWVNWWNESRLHQSLDYRTPAEVEAEFWEHHPGRE
>NC_016786|2231253:2282578|2273490_2274318_-|WP_014302543.1|DBSCAN-SWA
MSALIVSDIDGTLIDSRERIPSAVKESLAAAQRAGVSFVVATGRPARWIHPIIDQLYTPPTLCVCANGAVIYDPACDRITHRRELAPDAMRTVVRVAREALSDLGGCGVGVERAGVSAHDMPGELFMVTPDFVHSWESIEHSTVELDRVLARSAVKLLLRNDALTSEQMHRLVAPVVPADVAHVTYSMPDGLLEVMQPGVNKSSALDVVAQDLGVDPADAIAFGDMLNDLEMIRWAGTGVAMGNACDQLQRAADVVAPTNDEAGIAVVLREWLQG
>NC_016786|2231253:2282578|2239418_2241239_+|WP_014302520.1|DBSCAN-SWA
MQQRRRLISRTPKPVTAAIMAITLVGAAAVGVSTNSVLFTQGDAIAPINPELTTSSLADGNNVLVTDPAIATQGEGEGPKTVKEFHREQPFSQFALTWNGERDIAAFVRGQRPDGTWTEWFDTEPLDYGSDNPNHKKGTDLIYIEPTTTVQVSISGVDVLGPDAANLDAVFIDGGTSDLPENGINLTADSDGMPRVISRAGWGADESLRCSRPEYEDSTAAIVIHHTAGSNNYSQKESPGIMRGIYKYHAQTLGWCDIGYHALADKYGNLFEGRYGGLNKSIVGAHAGGFNSNTWAISMMGNYDVVQPPQAMIKSVGELAGWRAKVAGIDPKGSDTHYSEGSSYTFYPYGQAVLLPNIFAHRDVGNTACPGRYGYAQMDNIRNIAKQKYDSIRSGSGATAPAAPSTPSKPAPAPAAPAAPSAPAAPAGTNPIGLLSQGSTPANAGSLVGLAVAAATSLGLIGNLNNIGDVPVIGGLKLSQLQPIIGKIVELLGNNDVSRVWRDVNSFAGAALGNARSPIAHYASATGTPIDYALFDNGIVISNPETGTNALWGTIGDLWAQQGFEAGPLGLPTSSVFEVDGLQRVNFQHGYITFNPTTSAVDIQVQ
>NC_016786|2231253:2282578|2269725_2271450_-|WP_014302541.1|DBSCAN-SWA
MTTKSHCTFNPDYYQDVWQRFGEEEYDVVVIGGGSVGAGAGLDAAIRGLKVAVVESRDFAAGTSSRSSKMFHGGLRYLAMLDFKLVAESLHERELNMSTLAPHLVKPLKFLFPLTHHVWERVMMFGGFTLYDLMGGAKSVPMQKHYSRKGTLAMAPGLKDDAVVGSVRYFDTLVDDARHTMTVLRTAGELGADVRPSTQVVGFEKDGQRVVGAILQDTDNGEQTTIRGKVFINATGVWNDHIEKLAGGNGPFSVHASKGVHIVVPKNVFDADAAMCFVTEKSVLFVIPWGEYWIIGTTDTDWDLNRADPAPTAADINYILDEVNQRVRRPIQHSDIVGVYSGLRPLLSGKSDTTTKLSRNHAVAKVMPGLVSVAGGKYTTYRVIGKDAVDLAAEDLDFRVPASESERTPILGADGYHALQNQAPRIARTFGTTEDVVEHLLGRYGSLVHEVLEPSVDKPELLEPIPGAPGYIKAEAVYAVTHEGALHVEDIVERRLRAGIEYADRGVAAAPAIAELVADYLGWDAERTAAEVTAFTDRVSAEIAAEKELTDKAANEHIVAGSAVRSYVDVSGDN
>NC_016786|2231253:2282578|2243759_2245316_-|WP_014302522.1|DBSCAN-SWA
MSLPGFEISAQFRFLLSVTALLVREEFGRAPSLEQTQSLLQNGFSSAVVEKVNQNLVSHLNVLDGLQPFMGRPRLHPEGPKDASRRIGPGDQEVKKLSPAMPSEQGEDYWNLLVEFPDSLSISEATLKIVTYHYFSMAGNNKFDGDKTRMGAPGIRFPGKGYAATEHIWIREGSSLLRSLLTSLPTSWVKGEGLPAWADRTAQKSRTGQQQFHALWEATWSSNTVVSYWEDGYLTGVRVGGIPPAWWPDIPNTKEGEKALKLWWDQRNEKDPLYFYLKNKKGEPKAQRIDFGRDGIDLAVEWAAEAKMMDLVEKTYKNVLPVDSYPTVDGDDEGIDKYQLVFFRHQVEGTASSPSIRASEVFLADRSVWAFDLSCDEQLRLRDNAQLVRDVYITLLGVFRRKSAADASREVATGWGAAVLDSLAVSQSDASDAYWRGVTDVYQKYLADLRVGEEITEELYRGIRSAALEAYDEVTAPYLAQYANEIYYVRASLVRSVNSKINTARDEGIGRIKEESNE
>NC_016786|2231253:2282578|2238673_2238949_-|WP_010935661.1|DBSCAN-SWA
MTDTLDLSPKREVARLFGGQAQRVVLARAFVQQPDVLLLDEPTSVLDIGHAQDVLELIDAMRTTRNLTVERVEKIYNAKVKTCGRIIVPRR
>NC_016786|2231253:2282578|2253874_2254684_-|WP_014308874.1|DBSCAN-SWA
MKKSHLFRIPAATTAAVALLLASGPIANADGRTITGATDGLNISDIRCDTGSLTLIKRPPAAFEGVDKADLPAGTIDGATFTLRRIEGIDLTKQAGWDAAKALTIQEARSRLSDEVWKAVSGRDGRAVVTGLPMGVYLVSETPPAKRPAEYRRTLDFLITVPAGMRTADGNVASWSCDVQVFTKDTDDLPPTVPVFPPVESSVTLTPSSPVPGTPKTPGKPDLPEKFRKEVTDRLGNTGANVLGIAALGIALAIAGFLVQRRKKNEENG
>NC_016786|2231253:2282578|2262975_2263149_+|WP_014302535.1|DBSCAN-SWA
MSRWENLRTCQGKFDQDAKNRVVRLVEDRILAENMSMQAASKIVAPKLGVSWHTARQ
>NC_016786|2231253:2282578|2250587_2250761_+|WP_158308708.1|DBSCAN-SWA
MMRVSDGSLMDSESQKILSDIATETGFQVWVELVDETGEHGIVIEDGQVRELIEEAV
>NC_016786|2231253:2282578|2266973_2267345_+|WP_004567374.1|DBSCAN-SWA
MEAWIPPVTGVLTLVCALLFGIIAIKSKHRTLPRNSIVGIRLVSTLKSDEAWKASHQKTWGIPALSSAIFLIGGLLLIFPEKTTEARYVLVTAVTYGCLIPLLAIQGTLANRAANQQLQHSNN
>NC_016786|2231253:2282578|2252757_2253147_+|WP_014302527.1|DBSCAN-SWA
MPKAFPGEPLPKELNRLVGHVLYGWRDRPRRGEVDYPHTENIRMGHTWDSKRDVSKFDKSWSDQNIVDAIVATLENPDYALSGKVKRVVWKDIHGTTVRVSYNVCLMVGVISDRAYSDTPDRKAKRIVE
>NC_016786|2231253:2282578|2253136_2253412_+|WP_010935675.1|DBSCAN-SWA
MLSSKEVYARLDAILPSSVDREDAESNLNAGEIEYAITALLDDAYTSVGLSDAVVSLIRENYDDGPVIDMLDALLYFQKLNSGGDAVRMQR
>NC_016786|2231253:2282578|2236932_2237139_-|WP_041630952.1|DBSCAN-SWA
MAGFLLGSDINKILSVQSRDALLAGWKNVDDQAVERCVWRLEIPSKNAPQIEVRYTQIMAVLEGICGA
>NC_016786|2231253:2282578|2279790_2280693_-|WP_014302549.1|DBSCAN-SWA
MRIAYLGPEGTFTEVALWKFATRLGLESVGTIAAANPREAIAAVAAEQADYACVAIENSVDGPVTPTFDALATIDGVRIFHELDLPIAFAIMQRTGAPLRRFATHPVAYQQVKTWLAANAPAAEFVPASSNAEAARMAKEKIVDFAAAPARAADVYGLNIIADGVADVTGARTRFVLVGHADTPTPRTGHDRTSVVFTLKNEPGSLVGALSEFAMRGVDLTRIESRPIEEGLGTYRFHVDINGHIDDLNVAEALRALYPRCNALKFIGSWPAISGQPVTAVDPTVAQAASAWVEAARNGA
>NC_016786|2231253:2282578|2263493_2263658_+|WP_014302536.1|transposase|DBSCAN-SWA
MTFISENYGVYGVWKMWRVLQRQGIDIGREHKARLMRSAGLSGKGQRWGTCHNA

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014307698.1|2231253_2233479_-|holin	choline BCCT transporter BetT	A0A2I7QNT1	Vibrio_phage	3.3e-17	25.9
WP_014302516.1|2233750_2235544_+|holin	choline dehydrogenase	A0A1V0S9M4	Catovirus	1.6e-54	28.1
WP_014302517.1|2235730_2236894_-	UDP-galactopyranose mutase	E4ZFQ1	Streptococcus_phage	1.3e-94	46.1
WP_041630952.1|2236932_2237139_-	hypothetical protein	NA	NA	NA	NA
WP_041727284.1|2237587_2238430_-	type IV toxin-antitoxin system AbiEi family antitoxin	NA	NA	NA	NA
WP_010935661.1|2238673_2238949_-	ATP-binding cassette domain-containing protein	NA	NA	NA	NA
WP_014302520.1|2239418_2241239_+	N-acetylmuramoyl-L-alanine amidase	A0A159B6I5	Gordonia_phage	8.9e-05	34.8
WP_010935663.1|2241347_2242076_-	type I-E CRISPR-associated protein Cas5/CasD	NA	NA	NA	NA
WP_010935664.1|2242068_2243127_-	type I-E CRISPR-associated protein Cas7/Cse4/CasC	NA	NA	NA	NA
WP_014302521.1|2243182_2243767_-	type I-E CRISPR-associated protein Cse2/CasB	NA	NA	NA	NA
WP_014302522.1|2243759_2245316_-	CRISPR-associated protein	NA	NA	NA	NA
WP_010935667.1|2245681_2246368_+	type I-E CRISPR-associated protein Cas6/Cse3/CasE	NA	NA	NA	NA
WP_014302523.1|2246367_2248998_+	CRISPR-associated helicase/endonuclease Cas3	NA	NA	NA	NA
WP_010935669.1|2248999_2249959_+	type I-E CRISPR-associated endonuclease Cas1	A0A2D0YZM7	Vibrio_phage	1.1e-09	28.0
WP_010935670.1|2249959_2250274_+	type I-E CRISPR-associated endoribonuclease Cas2	NA	NA	NA	NA
WP_158308708.1|2250587_2250761_+	hypothetical protein	NA	NA	NA	NA
WP_010935671.1|2250819_2251335_+	single-stranded DNA-binding protein	A0A0U4B2E8	Arthrobacter_phage	4.4e-42	65.9
WP_014302525.1|2251353_2251551_+	hypothetical protein	NA	NA	NA	NA
WP_014302526.1|2252053_2252731_+	hypothetical protein	G1BSM8	Mycobacterium_virus	9.9e-10	32.6
WP_014302527.1|2252757_2253147_+	hypothetical protein	NA	NA	NA	NA
WP_010935675.1|2253136_2253412_+	hypothetical protein	NA	NA	NA	NA
WP_014302528.1|2253567_2253717_+	hypothetical protein	NA	NA	NA	NA
WP_014308874.1|2253874_2254684_-	SpaH fimbrial minor subunit SpaI	NA	NA	NA	NA
WP_014309675.1|2254757_2255804_-	SpaH fimbrial biogenesis class C sortase SrtE	NA	NA	NA	NA
WP_014302532.1|2255787_2256744_-	SpaH fimbrial biogenesis class C sortase SrtD	NA	NA	NA	NA
WP_014302533.1|2256933_2258601_-	SpaH fimbrial major subunit SpaH	NA	NA	NA	NA
2258273:2258287	attL	NA	NA	NA	NA
WP_014302534.1|2258704_2262832_-	SpaH fimbrial tip protein SpaG	NA	NA	NA	NA
WP_014302535.1|2262975_2263149_+	hypothetical protein	NA	NA	NA	NA
WP_014302536.1|2263493_2263658_+|transposase	IS3 family transposase	NA	NA	NA	NA
WP_157891399.1|2263696_2263960_+|integrase,transposase	DDE-type integrase/transposase/recombinase	A0A1B3AZE5	Gordonia_phage	2.3e-07	59.1
WP_014302538.1|2264088_2264223_+|transposase	transposase	NA	NA	NA	NA
WP_004567374.1|2266973_2267345_+	SdpI family protein	NA	NA	NA	NA
WP_004567377.1|2267446_2268967_-	glycerol kinase GlpK	NA	NA	NA	NA
WP_014302540.1|2268985_2269726_-	aquaporin family protein	M1HWZ0	Paramecium_bursaria_Chlorella_virus	2.7e-16	29.3
2269672:2269686	attR	NA	NA	NA	NA
WP_014302541.1|2269725_2271450_-	glycerol-3-phosphate dehydrogenase/oxidase	NA	NA	NA	NA
WP_014302542.1|2271645_2273478_-	1-acyl-sn-glycerol-3-phosphate acyltransferase	NA	NA	NA	NA
WP_014302543.1|2273490_2274318_-	Cof-type HAD-IIB family hydrolase	NA	NA	NA	NA
WP_004567386.1|2274347_2275607_-|tRNA	serine--tRNA ligase	A0A1B1IVT2	uncultured_Mediterranean_phage	1.3e-55	31.1
WP_042382035.1|2275704_2276478_+	GntR family transcriptional regulator	NA	NA	NA	NA
WP_014302545.1|2276479_2277481_+	septum formation family protein	NA	NA	NA	NA
WP_014302546.1|2277487_2277835_+	metallopeptidase family protein	NA	NA	NA	NA
WP_014302547.1|2277886_2279134_+	ATP-binding protein	NA	NA	NA	NA
WP_014302548.1|2279119_2279746_-	histidine phosphatase family protein	NA	NA	NA	NA
WP_014302549.1|2279790_2280693_-	prephenate dehydratase	NA	NA	NA	NA
WP_014302550.1|2280728_2281865_+	amidase	NA	NA	NA	NA
WP_014302551.1|2281861_2282578_+|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA